data_9DGI
# 
_entry.id   9DGI 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DGI         pdb_00009dgi 10.2210/pdb9dgi/pdb 
WWPDB D_1000288057 ?            ?                   
EMDB  EMD-46828    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-30 ? 
2 'Structure model' 1 1 2025-05-07 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
6 2 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DGI 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-02 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
EMDB 'Receptor alone using mask'                           EMD-29898 'other EM volume'      
EMDB 'Cannabinoid receptor 1-Gi complex with novel ligand' EMD-46828 'associated EM volume' 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
2 allan.basbaum@ucsf.edu         Allan      Basbaum     I 'principal investigator/group leader' 0000-0002-1710-6333 
3 a.makriyannis@northeastern.edu Alexandros Makriyannis ? 'principal investigator/group leader' 0000-0003-3272-3687 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Tummino, T.A.'              1 ? 
'Iliopoulos-Tsoutsouvas, C.' 2 ? 
'Braz, J.M.'                 3 ? 
;O'Brien, E.S.
;
4 ? 
'Krishna Kumar, K.'          5 ? 
'Makriyannis, M.'            6 ? 
'Basbaum, A.I.'              7 ? 
'Shoichet, B.K.'             8 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                2237 
_citation.page_last                 2237 
_citation.title                     'Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-025-57136-7 
_citation.pdbx_database_id_PubMed   40044644 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tummino, T.A.'              1  ? 
primary 'Iliopoulos-Tsoutsouvas, C.' 2  ? 
primary 'Braz, J.M.'                 3  ? 
primary 
;O'Brien, E.S.
;
4  ? 
primary 'Stein, R.M.'                5  ? 
primary 'Craik, V.'                  6  ? 
primary 'Tran, N.K.'                 7  ? 
primary 'Ganapathy, S.'              8  ? 
primary 'Liu, F.'                    9  ? 
primary 'Shiimura, Y.'               10 ? 
primary 'Tong, F.'                   11 ? 
primary 'Ho, T.C.'                   12 ? 
primary 'Radchenko, D.S.'            13 ? 
primary 'Moroz, Y.S.'                14 ? 
primary 'Rosado, S.R.'               15 ? 
primary 'Bhardwaj, K.'               16 ? 
primary 'Benitez, J.'                17 ? 
primary 'Liu, Y.'                    18 ? 
primary 'Kandasamy, H.'              19 ? 
primary 'Normand, C.'                20 ? 
primary 'Semache, M.'                21 ? 
primary 'Sabbagh, L.'                22 ? 
primary 'Glenn, I.'                  23 ? 
primary 'Irwin, J.J.'                24 ? 
primary 'Kumar, K.K.'                25 ? 
primary 'Makriyannis, A.'            26 ? 
primary 'Basbaum, A.I.'              27 ? 
primary 'Shoichet, B.K.'             28 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Cannabinoid receptor 1' 55678.535 1 ? ? ? ? 
2 non-polymer syn 
'methyl (2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate' 437.435   
1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        CB1,CANN6 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;DYKDDDDAMKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVP
ADQVNITEFYNKSLSENLYFQGSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSR
SLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYK
RIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHA
VRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML
CLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVST
DTSAEALGSHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;DYKDDDDAMKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVP
ADQVNITEFYNKSLSENLYFQGSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSR
SLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYK
RIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHA
VRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSML
CLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVST
DTSAEALGSHHHHHH
;
_entity_poly.pdbx_strand_id                 R 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        
'methyl (2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate' 
_pdbx_entity_nonpoly.comp_id     YVF 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   TYR n 
1 3   LYS n 
1 4   ASP n 
1 5   ASP n 
1 6   ASP n 
1 7   ASP n 
1 8   ALA n 
1 9   MET n 
1 10  LYS n 
1 11  SER n 
1 12  ILE n 
1 13  LEU n 
1 14  ASP n 
1 15  GLY n 
1 16  LEU n 
1 17  ALA n 
1 18  ASP n 
1 19  THR n 
1 20  THR n 
1 21  PHE n 
1 22  ARG n 
1 23  THR n 
1 24  ILE n 
1 25  THR n 
1 26  THR n 
1 27  ASP n 
1 28  LEU n 
1 29  LEU n 
1 30  TYR n 
1 31  VAL n 
1 32  GLY n 
1 33  SER n 
1 34  ASN n 
1 35  ASP n 
1 36  ILE n 
1 37  GLN n 
1 38  TYR n 
1 39  GLU n 
1 40  ASP n 
1 41  ILE n 
1 42  LYS n 
1 43  GLY n 
1 44  ASP n 
1 45  MET n 
1 46  ALA n 
1 47  SER n 
1 48  LYS n 
1 49  LEU n 
1 50  GLY n 
1 51  TYR n 
1 52  PHE n 
1 53  PRO n 
1 54  GLN n 
1 55  LYS n 
1 56  PHE n 
1 57  PRO n 
1 58  LEU n 
1 59  THR n 
1 60  SER n 
1 61  PHE n 
1 62  ARG n 
1 63  GLY n 
1 64  SER n 
1 65  PRO n 
1 66  PHE n 
1 67  GLN n 
1 68  GLU n 
1 69  LYS n 
1 70  MET n 
1 71  THR n 
1 72  ALA n 
1 73  GLY n 
1 74  ASP n 
1 75  ASN n 
1 76  PRO n 
1 77  GLN n 
1 78  LEU n 
1 79  VAL n 
1 80  PRO n 
1 81  ALA n 
1 82  ASP n 
1 83  GLN n 
1 84  VAL n 
1 85  ASN n 
1 86  ILE n 
1 87  THR n 
1 88  GLU n 
1 89  PHE n 
1 90  TYR n 
1 91  ASN n 
1 92  LYS n 
1 93  SER n 
1 94  LEU n 
1 95  SER n 
1 96  GLU n 
1 97  ASN n 
1 98  LEU n 
1 99  TYR n 
1 100 PHE n 
1 101 GLN n 
1 102 GLY n 
1 103 SER n 
1 104 PHE n 
1 105 LYS n 
1 106 GLU n 
1 107 ASN n 
1 108 GLU n 
1 109 GLU n 
1 110 ASN n 
1 111 ILE n 
1 112 GLN n 
1 113 CYS n 
1 114 GLY n 
1 115 GLU n 
1 116 ASN n 
1 117 PHE n 
1 118 MET n 
1 119 ASP n 
1 120 ILE n 
1 121 GLU n 
1 122 CYS n 
1 123 PHE n 
1 124 MET n 
1 125 VAL n 
1 126 LEU n 
1 127 ASN n 
1 128 PRO n 
1 129 SER n 
1 130 GLN n 
1 131 GLN n 
1 132 LEU n 
1 133 ALA n 
1 134 ILE n 
1 135 ALA n 
1 136 VAL n 
1 137 LEU n 
1 138 SER n 
1 139 LEU n 
1 140 THR n 
1 141 LEU n 
1 142 GLY n 
1 143 THR n 
1 144 PHE n 
1 145 THR n 
1 146 VAL n 
1 147 LEU n 
1 148 GLU n 
1 149 ASN n 
1 150 LEU n 
1 151 LEU n 
1 152 VAL n 
1 153 LEU n 
1 154 CYS n 
1 155 VAL n 
1 156 ILE n 
1 157 LEU n 
1 158 HIS n 
1 159 SER n 
1 160 ARG n 
1 161 SER n 
1 162 LEU n 
1 163 ARG n 
1 164 CYS n 
1 165 ARG n 
1 166 PRO n 
1 167 SER n 
1 168 TYR n 
1 169 HIS n 
1 170 PHE n 
1 171 ILE n 
1 172 GLY n 
1 173 SER n 
1 174 LEU n 
1 175 ALA n 
1 176 VAL n 
1 177 ALA n 
1 178 ASP n 
1 179 LEU n 
1 180 LEU n 
1 181 GLY n 
1 182 SER n 
1 183 VAL n 
1 184 ILE n 
1 185 PHE n 
1 186 VAL n 
1 187 TYR n 
1 188 SER n 
1 189 PHE n 
1 190 ILE n 
1 191 ASP n 
1 192 PHE n 
1 193 HIS n 
1 194 VAL n 
1 195 PHE n 
1 196 HIS n 
1 197 ARG n 
1 198 LYS n 
1 199 ASP n 
1 200 SER n 
1 201 ARG n 
1 202 ASN n 
1 203 VAL n 
1 204 PHE n 
1 205 LEU n 
1 206 PHE n 
1 207 LYS n 
1 208 LEU n 
1 209 GLY n 
1 210 GLY n 
1 211 VAL n 
1 212 THR n 
1 213 ALA n 
1 214 SER n 
1 215 PHE n 
1 216 THR n 
1 217 ALA n 
1 218 SER n 
1 219 VAL n 
1 220 GLY n 
1 221 SER n 
1 222 LEU n 
1 223 PHE n 
1 224 LEU n 
1 225 THR n 
1 226 ALA n 
1 227 ILE n 
1 228 ASP n 
1 229 ARG n 
1 230 TYR n 
1 231 ILE n 
1 232 SER n 
1 233 ILE n 
1 234 HIS n 
1 235 ARG n 
1 236 PRO n 
1 237 LEU n 
1 238 ALA n 
1 239 TYR n 
1 240 LYS n 
1 241 ARG n 
1 242 ILE n 
1 243 VAL n 
1 244 THR n 
1 245 ARG n 
1 246 PRO n 
1 247 LYS n 
1 248 ALA n 
1 249 VAL n 
1 250 VAL n 
1 251 ALA n 
1 252 PHE n 
1 253 CYS n 
1 254 LEU n 
1 255 MET n 
1 256 TRP n 
1 257 THR n 
1 258 ILE n 
1 259 ALA n 
1 260 ILE n 
1 261 VAL n 
1 262 ILE n 
1 263 ALA n 
1 264 VAL n 
1 265 LEU n 
1 266 PRO n 
1 267 LEU n 
1 268 LEU n 
1 269 GLY n 
1 270 TRP n 
1 271 ASN n 
1 272 CYS n 
1 273 GLU n 
1 274 LYS n 
1 275 LEU n 
1 276 GLN n 
1 277 SER n 
1 278 VAL n 
1 279 CYS n 
1 280 SER n 
1 281 ASP n 
1 282 ILE n 
1 283 PHE n 
1 284 PRO n 
1 285 HIS n 
1 286 ILE n 
1 287 ASP n 
1 288 GLU n 
1 289 THR n 
1 290 TYR n 
1 291 LEU n 
1 292 MET n 
1 293 PHE n 
1 294 TRP n 
1 295 ILE n 
1 296 GLY n 
1 297 VAL n 
1 298 THR n 
1 299 SER n 
1 300 VAL n 
1 301 LEU n 
1 302 LEU n 
1 303 LEU n 
1 304 PHE n 
1 305 ILE n 
1 306 VAL n 
1 307 TYR n 
1 308 ALA n 
1 309 TYR n 
1 310 MET n 
1 311 TYR n 
1 312 ILE n 
1 313 LEU n 
1 314 TRP n 
1 315 LYS n 
1 316 ALA n 
1 317 HIS n 
1 318 SER n 
1 319 HIS n 
1 320 ALA n 
1 321 VAL n 
1 322 ARG n 
1 323 MET n 
1 324 ILE n 
1 325 GLN n 
1 326 ARG n 
1 327 GLY n 
1 328 THR n 
1 329 GLN n 
1 330 LYS n 
1 331 SER n 
1 332 ILE n 
1 333 ILE n 
1 334 ILE n 
1 335 HIS n 
1 336 THR n 
1 337 SER n 
1 338 GLU n 
1 339 ASP n 
1 340 GLY n 
1 341 LYS n 
1 342 VAL n 
1 343 GLN n 
1 344 VAL n 
1 345 THR n 
1 346 ARG n 
1 347 PRO n 
1 348 ASP n 
1 349 GLN n 
1 350 ALA n 
1 351 ARG n 
1 352 MET n 
1 353 ASP n 
1 354 ILE n 
1 355 ARG n 
1 356 LEU n 
1 357 ALA n 
1 358 LYS n 
1 359 THR n 
1 360 LEU n 
1 361 VAL n 
1 362 LEU n 
1 363 ILE n 
1 364 LEU n 
1 365 VAL n 
1 366 VAL n 
1 367 LEU n 
1 368 ILE n 
1 369 ILE n 
1 370 CYS n 
1 371 TRP n 
1 372 GLY n 
1 373 PRO n 
1 374 LEU n 
1 375 LEU n 
1 376 ALA n 
1 377 ILE n 
1 378 MET n 
1 379 VAL n 
1 380 TYR n 
1 381 ASP n 
1 382 VAL n 
1 383 PHE n 
1 384 GLY n 
1 385 LYS n 
1 386 MET n 
1 387 ASN n 
1 388 LYS n 
1 389 LEU n 
1 390 ILE n 
1 391 LYS n 
1 392 THR n 
1 393 VAL n 
1 394 PHE n 
1 395 ALA n 
1 396 PHE n 
1 397 CYS n 
1 398 SER n 
1 399 MET n 
1 400 LEU n 
1 401 CYS n 
1 402 LEU n 
1 403 LEU n 
1 404 ASN n 
1 405 SER n 
1 406 THR n 
1 407 VAL n 
1 408 ASN n 
1 409 PRO n 
1 410 ILE n 
1 411 ILE n 
1 412 TYR n 
1 413 ALA n 
1 414 LEU n 
1 415 ARG n 
1 416 SER n 
1 417 LYS n 
1 418 ASP n 
1 419 LEU n 
1 420 ARG n 
1 421 HIS n 
1 422 ALA n 
1 423 PHE n 
1 424 ARG n 
1 425 SER n 
1 426 MET n 
1 427 PHE n 
1 428 PRO n 
1 429 SER n 
1 430 CYS n 
1 431 GLU n 
1 432 GLY n 
1 433 THR n 
1 434 ALA n 
1 435 GLN n 
1 436 PRO n 
1 437 LEU n 
1 438 ASP n 
1 439 ASN n 
1 440 SER n 
1 441 MET n 
1 442 GLY n 
1 443 ASP n 
1 444 SER n 
1 445 ASP n 
1 446 CYS n 
1 447 LEU n 
1 448 HIS n 
1 449 LYS n 
1 450 HIS n 
1 451 ALA n 
1 452 ASN n 
1 453 ASN n 
1 454 ALA n 
1 455 ALA n 
1 456 SER n 
1 457 VAL n 
1 458 HIS n 
1 459 ARG n 
1 460 ALA n 
1 461 ALA n 
1 462 GLU n 
1 463 SER n 
1 464 CYS n 
1 465 ILE n 
1 466 LYS n 
1 467 SER n 
1 468 THR n 
1 469 VAL n 
1 470 LYS n 
1 471 ILE n 
1 472 ALA n 
1 473 LYS n 
1 474 VAL n 
1 475 THR n 
1 476 MET n 
1 477 SER n 
1 478 VAL n 
1 479 SER n 
1 480 THR n 
1 481 ASP n 
1 482 THR n 
1 483 SER n 
1 484 ALA n 
1 485 GLU n 
1 486 ALA n 
1 487 LEU n 
1 488 GLY n 
1 489 SER n 
1 490 HIS n 
1 491 HIS n 
1 492 HIS n 
1 493 HIS n 
1 494 HIS n 
1 495 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   495 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'CNR1, CNR' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Spodoptera aff. frugiperda 1 BOLD-2017' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     2449148 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'         89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1'     175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'        132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'         133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'       121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'       146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'         147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'         75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1'     156.162 
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'        131.173 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'        131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1'     147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'      149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'        165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'         115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'         105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'         119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'      204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'        181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'        117.146 
YVF non-polymer         . 
'methyl (2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate' ? 
'C20 H18 F3 N3 O3 S' 437.435 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   -14 ?   ?   ?   R . n 
A 1 2   TYR 2   -13 ?   ?   ?   R . n 
A 1 3   LYS 3   -12 ?   ?   ?   R . n 
A 1 4   ASP 4   -11 ?   ?   ?   R . n 
A 1 5   ASP 5   -10 ?   ?   ?   R . n 
A 1 6   ASP 6   -9  ?   ?   ?   R . n 
A 1 7   ASP 7   -8  ?   ?   ?   R . n 
A 1 8   ALA 8   -7  ?   ?   ?   R . n 
A 1 9   MET 9   -6  ?   ?   ?   R . n 
A 1 10  LYS 10  -5  ?   ?   ?   R . n 
A 1 11  SER 11  -4  ?   ?   ?   R . n 
A 1 12  ILE 12  -3  ?   ?   ?   R . n 
A 1 13  LEU 13  -2  ?   ?   ?   R . n 
A 1 14  ASP 14  -1  ?   ?   ?   R . n 
A 1 15  GLY 15  0   ?   ?   ?   R . n 
A 1 16  LEU 16  1   ?   ?   ?   R . n 
A 1 17  ALA 17  2   ?   ?   ?   R . n 
A 1 18  ASP 18  3   ?   ?   ?   R . n 
A 1 19  THR 19  4   ?   ?   ?   R . n 
A 1 20  THR 20  5   ?   ?   ?   R . n 
A 1 21  PHE 21  6   ?   ?   ?   R . n 
A 1 22  ARG 22  7   ?   ?   ?   R . n 
A 1 23  THR 23  8   ?   ?   ?   R . n 
A 1 24  ILE 24  9   ?   ?   ?   R . n 
A 1 25  THR 25  10  ?   ?   ?   R . n 
A 1 26  THR 26  11  ?   ?   ?   R . n 
A 1 27  ASP 27  12  ?   ?   ?   R . n 
A 1 28  LEU 28  13  ?   ?   ?   R . n 
A 1 29  LEU 29  14  ?   ?   ?   R . n 
A 1 30  TYR 30  15  ?   ?   ?   R . n 
A 1 31  VAL 31  16  ?   ?   ?   R . n 
A 1 32  GLY 32  17  ?   ?   ?   R . n 
A 1 33  SER 33  18  ?   ?   ?   R . n 
A 1 34  ASN 34  19  ?   ?   ?   R . n 
A 1 35  ASP 35  20  ?   ?   ?   R . n 
A 1 36  ILE 36  21  ?   ?   ?   R . n 
A 1 37  GLN 37  22  ?   ?   ?   R . n 
A 1 38  TYR 38  23  ?   ?   ?   R . n 
A 1 39  GLU 39  24  ?   ?   ?   R . n 
A 1 40  ASP 40  25  ?   ?   ?   R . n 
A 1 41  ILE 41  26  ?   ?   ?   R . n 
A 1 42  LYS 42  27  ?   ?   ?   R . n 
A 1 43  GLY 43  28  ?   ?   ?   R . n 
A 1 44  ASP 44  29  ?   ?   ?   R . n 
A 1 45  MET 45  30  ?   ?   ?   R . n 
A 1 46  ALA 46  31  ?   ?   ?   R . n 
A 1 47  SER 47  32  ?   ?   ?   R . n 
A 1 48  LYS 48  33  ?   ?   ?   R . n 
A 1 49  LEU 49  34  ?   ?   ?   R . n 
A 1 50  GLY 50  35  ?   ?   ?   R . n 
A 1 51  TYR 51  36  ?   ?   ?   R . n 
A 1 52  PHE 52  37  ?   ?   ?   R . n 
A 1 53  PRO 53  38  ?   ?   ?   R . n 
A 1 54  GLN 54  39  ?   ?   ?   R . n 
A 1 55  LYS 55  40  ?   ?   ?   R . n 
A 1 56  PHE 56  41  ?   ?   ?   R . n 
A 1 57  PRO 57  42  ?   ?   ?   R . n 
A 1 58  LEU 58  43  ?   ?   ?   R . n 
A 1 59  THR 59  44  ?   ?   ?   R . n 
A 1 60  SER 60  45  ?   ?   ?   R . n 
A 1 61  PHE 61  46  ?   ?   ?   R . n 
A 1 62  ARG 62  47  ?   ?   ?   R . n 
A 1 63  GLY 63  48  ?   ?   ?   R . n 
A 1 64  SER 64  49  ?   ?   ?   R . n 
A 1 65  PRO 65  50  ?   ?   ?   R . n 
A 1 66  PHE 66  51  ?   ?   ?   R . n 
A 1 67  GLN 67  52  ?   ?   ?   R . n 
A 1 68  GLU 68  53  ?   ?   ?   R . n 
A 1 69  LYS 69  54  ?   ?   ?   R . n 
A 1 70  MET 70  55  ?   ?   ?   R . n 
A 1 71  THR 71  56  ?   ?   ?   R . n 
A 1 72  ALA 72  57  ?   ?   ?   R . n 
A 1 73  GLY 73  58  ?   ?   ?   R . n 
A 1 74  ASP 74  59  ?   ?   ?   R . n 
A 1 75  ASN 75  60  ?   ?   ?   R . n 
A 1 76  PRO 76  61  ?   ?   ?   R . n 
A 1 77  GLN 77  62  ?   ?   ?   R . n 
A 1 78  LEU 78  63  ?   ?   ?   R . n 
A 1 79  VAL 79  64  ?   ?   ?   R . n 
A 1 80  PRO 80  65  ?   ?   ?   R . n 
A 1 81  ALA 81  66  ?   ?   ?   R . n 
A 1 82  ASP 82  67  ?   ?   ?   R . n 
A 1 83  GLN 83  68  ?   ?   ?   R . n 
A 1 84  VAL 84  69  ?   ?   ?   R . n 
A 1 85  ASN 85  70  ?   ?   ?   R . n 
A 1 86  ILE 86  71  ?   ?   ?   R . n 
A 1 87  THR 87  72  ?   ?   ?   R . n 
A 1 88  GLU 88  73  ?   ?   ?   R . n 
A 1 89  PHE 89  74  ?   ?   ?   R . n 
A 1 90  TYR 90  75  ?   ?   ?   R . n 
A 1 91  ASN 91  76  ?   ?   ?   R . n 
A 1 92  LYS 92  77  ?   ?   ?   R . n 
A 1 93  SER 93  78  ?   ?   ?   R . n 
A 1 94  LEU 94  79  ?   ?   ?   R . n 
A 1 95  SER 95  80  ?   ?   ?   R . n 
A 1 96  GLU 96  81  ?   ?   ?   R . n 
A 1 97  ASN 97  82  ?   ?   ?   R . n 
A 1 98  LEU 98  83  ?   ?   ?   R . n 
A 1 99  TYR 99  84  ?   ?   ?   R . n 
A 1 100 PHE 100 85  ?   ?   ?   R . n 
A 1 101 GLN 101 86  ?   ?   ?   R . n 
A 1 102 GLY 102 87  ?   ?   ?   R . n 
A 1 103 SER 103 88  ?   ?   ?   R . n 
A 1 104 PHE 104 89  ?   ?   ?   R . n 
A 1 105 LYS 105 90  ?   ?   ?   R . n 
A 1 106 GLU 106 91  ?   ?   ?   R . n 
A 1 107 ASN 107 92  ?   ?   ?   R . n 
A 1 108 GLU 108 93  ?   ?   ?   R . n 
A 1 109 GLU 109 94  ?   ?   ?   R . n 
A 1 110 ASN 110 95  ?   ?   ?   R . n 
A 1 111 ILE 111 96  ?   ?   ?   R . n 
A 1 112 GLN 112 97  ?   ?   ?   R . n 
A 1 113 CYS 113 98  ?   ?   ?   R . n 
A 1 114 GLY 114 99  ?   ?   ?   R . n 
A 1 115 GLU 115 100 ?   ?   ?   R . n 
A 1 116 ASN 116 101 ?   ?   ?   R . n 
A 1 117 PHE 117 102 ?   ?   ?   R . n 
A 1 118 MET 118 103 ?   ?   ?   R . n 
A 1 119 ASP 119 104 ?   ?   ?   R . n 
A 1 120 ILE 120 105 ?   ?   ?   R . n 
A 1 121 GLU 121 106 ?   ?   ?   R . n 
A 1 122 CYS 122 107 ?   ?   ?   R . n 
A 1 123 PHE 123 108 108 PHE PHE R . n 
A 1 124 MET 124 109 109 MET MET R . n 
A 1 125 VAL 125 110 110 VAL VAL R . n 
A 1 126 LEU 126 111 111 LEU LEU R . n 
A 1 127 ASN 127 112 112 ASN ASN R . n 
A 1 128 PRO 128 113 113 PRO PRO R . n 
A 1 129 SER 129 114 114 SER SER R . n 
A 1 130 GLN 130 115 115 GLN GLN R . n 
A 1 131 GLN 131 116 116 GLN GLN R . n 
A 1 132 LEU 132 117 117 LEU LEU R . n 
A 1 133 ALA 133 118 118 ALA ALA R . n 
A 1 134 ILE 134 119 119 ILE ILE R . n 
A 1 135 ALA 135 120 120 ALA ALA R . n 
A 1 136 VAL 136 121 121 VAL VAL R . n 
A 1 137 LEU 137 122 122 LEU LEU R . n 
A 1 138 SER 138 123 123 SER SER R . n 
A 1 139 LEU 139 124 124 LEU LEU R . n 
A 1 140 THR 140 125 125 THR THR R . n 
A 1 141 LEU 141 126 126 LEU LEU R . n 
A 1 142 GLY 142 127 127 GLY GLY R . n 
A 1 143 THR 143 128 128 THR THR R . n 
A 1 144 PHE 144 129 129 PHE PHE R . n 
A 1 145 THR 145 130 130 THR THR R . n 
A 1 146 VAL 146 131 131 VAL VAL R . n 
A 1 147 LEU 147 132 132 LEU LEU R . n 
A 1 148 GLU 148 133 133 GLU GLU R . n 
A 1 149 ASN 149 134 134 ASN ASN R . n 
A 1 150 LEU 150 135 135 LEU LEU R . n 
A 1 151 LEU 151 136 136 LEU LEU R . n 
A 1 152 VAL 152 137 137 VAL VAL R . n 
A 1 153 LEU 153 138 138 LEU LEU R . n 
A 1 154 CYS 154 139 139 CYS CYS R . n 
A 1 155 VAL 155 140 140 VAL VAL R . n 
A 1 156 ILE 156 141 141 ILE ILE R . n 
A 1 157 LEU 157 142 ?   ?   ?   R . n 
A 1 158 HIS 158 143 ?   ?   ?   R . n 
A 1 159 SER 159 144 ?   ?   ?   R . n 
A 1 160 ARG 160 145 ?   ?   ?   R . n 
A 1 161 SER 161 146 ?   ?   ?   R . n 
A 1 162 LEU 162 147 ?   ?   ?   R . n 
A 1 163 ARG 163 148 148 ARG ARG R . n 
A 1 164 CYS 164 149 149 CYS CYS R . n 
A 1 165 ARG 165 150 150 ARG ARG R . n 
A 1 166 PRO 166 151 151 PRO PRO R . n 
A 1 167 SER 167 152 152 SER SER R . n 
A 1 168 TYR 168 153 153 TYR TYR R . n 
A 1 169 HIS 169 154 154 HIS HIS R . n 
A 1 170 PHE 170 155 155 PHE PHE R . n 
A 1 171 ILE 171 156 156 ILE ILE R . n 
A 1 172 GLY 172 157 157 GLY GLY R . n 
A 1 173 SER 173 158 158 SER SER R . n 
A 1 174 LEU 174 159 159 LEU LEU R . n 
A 1 175 ALA 175 160 160 ALA ALA R . n 
A 1 176 VAL 176 161 161 VAL VAL R . n 
A 1 177 ALA 177 162 162 ALA ALA R . n 
A 1 178 ASP 178 163 163 ASP ASP R . n 
A 1 179 LEU 179 164 164 LEU LEU R . n 
A 1 180 LEU 180 165 165 LEU LEU R . n 
A 1 181 GLY 181 166 166 GLY GLY R . n 
A 1 182 SER 182 167 167 SER SER R . n 
A 1 183 VAL 183 168 168 VAL VAL R . n 
A 1 184 ILE 184 169 169 ILE ILE R . n 
A 1 185 PHE 185 170 170 PHE PHE R . n 
A 1 186 VAL 186 171 171 VAL VAL R . n 
A 1 187 TYR 187 172 172 TYR TYR R . n 
A 1 188 SER 188 173 173 SER SER R . n 
A 1 189 PHE 189 174 174 PHE PHE R . n 
A 1 190 ILE 190 175 175 ILE ILE R . n 
A 1 191 ASP 191 176 176 ASP ASP R . n 
A 1 192 PHE 192 177 177 PHE PHE R . n 
A 1 193 HIS 193 178 178 HIS HIS R . n 
A 1 194 VAL 194 179 179 VAL VAL R . n 
A 1 195 PHE 195 180 180 PHE PHE R . n 
A 1 196 HIS 196 181 181 HIS HIS R . n 
A 1 197 ARG 197 182 182 ARG ARG R . n 
A 1 198 LYS 198 183 183 LYS LYS R . n 
A 1 199 ASP 199 184 184 ASP ASP R . n 
A 1 200 SER 200 185 185 SER SER R . n 
A 1 201 ARG 201 186 186 ARG ARG R . n 
A 1 202 ASN 202 187 187 ASN ASN R . n 
A 1 203 VAL 203 188 188 VAL VAL R . n 
A 1 204 PHE 204 189 189 PHE PHE R . n 
A 1 205 LEU 205 190 190 LEU LEU R . n 
A 1 206 PHE 206 191 191 PHE PHE R . n 
A 1 207 LYS 207 192 192 LYS LYS R . n 
A 1 208 LEU 208 193 193 LEU LEU R . n 
A 1 209 GLY 209 194 194 GLY GLY R . n 
A 1 210 GLY 210 195 195 GLY GLY R . n 
A 1 211 VAL 211 196 196 VAL VAL R . n 
A 1 212 THR 212 197 197 THR THR R . n 
A 1 213 ALA 213 198 198 ALA ALA R . n 
A 1 214 SER 214 199 199 SER SER R . n 
A 1 215 PHE 215 200 200 PHE PHE R . n 
A 1 216 THR 216 201 201 THR THR R . n 
A 1 217 ALA 217 202 202 ALA ALA R . n 
A 1 218 SER 218 203 203 SER SER R . n 
A 1 219 VAL 219 204 204 VAL VAL R . n 
A 1 220 GLY 220 205 205 GLY GLY R . n 
A 1 221 SER 221 206 206 SER SER R . n 
A 1 222 LEU 222 207 207 LEU LEU R . n 
A 1 223 PHE 223 208 208 PHE PHE R . n 
A 1 224 LEU 224 209 209 LEU LEU R . n 
A 1 225 THR 225 210 210 THR THR R . n 
A 1 226 ALA 226 211 211 ALA ALA R . n 
A 1 227 ILE 227 212 212 ILE ILE R . n 
A 1 228 ASP 228 213 213 ASP ASP R . n 
A 1 229 ARG 229 214 214 ARG ARG R . n 
A 1 230 TYR 230 215 215 TYR TYR R . n 
A 1 231 ILE 231 216 216 ILE ILE R . n 
A 1 232 SER 232 217 217 SER SER R . n 
A 1 233 ILE 233 218 218 ILE ILE R . n 
A 1 234 HIS 234 219 219 HIS HIS R . n 
A 1 235 ARG 235 220 220 ARG ARG R . n 
A 1 236 PRO 236 221 221 PRO PRO R . n 
A 1 237 LEU 237 222 222 LEU LEU R . n 
A 1 238 ALA 238 223 223 ALA ALA R . n 
A 1 239 TYR 239 224 224 TYR TYR R . n 
A 1 240 LYS 240 225 225 LYS LYS R . n 
A 1 241 ARG 241 226 226 ARG ARG R . n 
A 1 242 ILE 242 227 227 ILE ILE R . n 
A 1 243 VAL 243 228 228 VAL VAL R . n 
A 1 244 THR 244 229 229 THR THR R . n 
A 1 245 ARG 245 230 230 ARG ARG R . n 
A 1 246 PRO 246 231 231 PRO PRO R . n 
A 1 247 LYS 247 232 232 LYS LYS R . n 
A 1 248 ALA 248 233 233 ALA ALA R . n 
A 1 249 VAL 249 234 234 VAL VAL R . n 
A 1 250 VAL 250 235 235 VAL VAL R . n 
A 1 251 ALA 251 236 236 ALA ALA R . n 
A 1 252 PHE 252 237 237 PHE PHE R . n 
A 1 253 CYS 253 238 238 CYS CYS R . n 
A 1 254 LEU 254 239 239 LEU LEU R . n 
A 1 255 MET 255 240 240 MET MET R . n 
A 1 256 TRP 256 241 241 TRP TRP R . n 
A 1 257 THR 257 242 242 THR THR R . n 
A 1 258 ILE 258 243 243 ILE ILE R . n 
A 1 259 ALA 259 244 244 ALA ALA R . n 
A 1 260 ILE 260 245 245 ILE ILE R . n 
A 1 261 VAL 261 246 246 VAL VAL R . n 
A 1 262 ILE 262 247 247 ILE ILE R . n 
A 1 263 ALA 263 248 248 ALA ALA R . n 
A 1 264 VAL 264 249 249 VAL VAL R . n 
A 1 265 LEU 265 250 250 LEU LEU R . n 
A 1 266 PRO 266 251 251 PRO PRO R . n 
A 1 267 LEU 267 252 252 LEU LEU R . n 
A 1 268 LEU 268 253 253 LEU LEU R . n 
A 1 269 GLY 269 254 ?   ?   ?   R . n 
A 1 270 TRP 270 255 ?   ?   ?   R . n 
A 1 271 ASN 271 256 ?   ?   ?   R . n 
A 1 272 CYS 272 257 ?   ?   ?   R . n 
A 1 273 GLU 273 258 ?   ?   ?   R . n 
A 1 274 LYS 274 259 ?   ?   ?   R . n 
A 1 275 LEU 275 260 ?   ?   ?   R . n 
A 1 276 GLN 276 261 ?   ?   ?   R . n 
A 1 277 SER 277 262 ?   ?   ?   R . n 
A 1 278 VAL 278 263 ?   ?   ?   R . n 
A 1 279 CYS 279 264 ?   ?   ?   R . n 
A 1 280 SER 280 265 ?   ?   ?   R . n 
A 1 281 ASP 281 266 266 ASP ASP R . n 
A 1 282 ILE 282 267 267 ILE ILE R . n 
A 1 283 PHE 283 268 268 PHE PHE R . n 
A 1 284 PRO 284 269 269 PRO PRO R . n 
A 1 285 HIS 285 270 270 HIS HIS R . n 
A 1 286 ILE 286 271 271 ILE ILE R . n 
A 1 287 ASP 287 272 272 ASP ASP R . n 
A 1 288 GLU 288 273 273 GLU GLU R . n 
A 1 289 THR 289 274 274 THR THR R . n 
A 1 290 TYR 290 275 275 TYR TYR R . n 
A 1 291 LEU 291 276 276 LEU LEU R . n 
A 1 292 MET 292 277 277 MET MET R . n 
A 1 293 PHE 293 278 278 PHE PHE R . n 
A 1 294 TRP 294 279 279 TRP TRP R . n 
A 1 295 ILE 295 280 280 ILE ILE R . n 
A 1 296 GLY 296 281 281 GLY GLY R . n 
A 1 297 VAL 297 282 282 VAL VAL R . n 
A 1 298 THR 298 283 283 THR THR R . n 
A 1 299 SER 299 284 284 SER SER R . n 
A 1 300 VAL 300 285 285 VAL VAL R . n 
A 1 301 LEU 301 286 286 LEU LEU R . n 
A 1 302 LEU 302 287 287 LEU LEU R . n 
A 1 303 LEU 303 288 288 LEU LEU R . n 
A 1 304 PHE 304 289 289 PHE PHE R . n 
A 1 305 ILE 305 290 290 ILE ILE R . n 
A 1 306 VAL 306 291 291 VAL VAL R . n 
A 1 307 TYR 307 292 292 TYR TYR R . n 
A 1 308 ALA 308 293 293 ALA ALA R . n 
A 1 309 TYR 309 294 294 TYR TYR R . n 
A 1 310 MET 310 295 295 MET MET R . n 
A 1 311 TYR 311 296 296 TYR TYR R . n 
A 1 312 ILE 312 297 297 ILE ILE R . n 
A 1 313 LEU 313 298 298 LEU LEU R . n 
A 1 314 TRP 314 299 299 TRP TRP R . n 
A 1 315 LYS 315 300 300 LYS LYS R . n 
A 1 316 ALA 316 301 301 ALA ALA R . n 
A 1 317 HIS 317 302 302 HIS HIS R . n 
A 1 318 SER 318 303 303 SER SER R . n 
A 1 319 HIS 319 304 304 HIS HIS R . n 
A 1 320 ALA 320 305 305 ALA ALA R . n 
A 1 321 VAL 321 306 306 VAL VAL R . n 
A 1 322 ARG 322 307 307 ARG ARG R . n 
A 1 323 MET 323 308 308 MET MET R . n 
A 1 324 ILE 324 309 309 ILE ILE R . n 
A 1 325 GLN 325 310 310 GLN GLN R . n 
A 1 326 ARG 326 311 311 ARG ARG R . n 
A 1 327 GLY 327 312 312 GLY GLY R . n 
A 1 328 THR 328 313 313 THR THR R . n 
A 1 329 GLN 329 314 ?   ?   ?   R . n 
A 1 330 LYS 330 315 ?   ?   ?   R . n 
A 1 331 SER 331 316 ?   ?   ?   R . n 
A 1 332 ILE 332 317 ?   ?   ?   R . n 
A 1 333 ILE 333 318 ?   ?   ?   R . n 
A 1 334 ILE 334 319 ?   ?   ?   R . n 
A 1 335 HIS 335 320 ?   ?   ?   R . n 
A 1 336 THR 336 321 ?   ?   ?   R . n 
A 1 337 SER 337 322 ?   ?   ?   R . n 
A 1 338 GLU 338 323 ?   ?   ?   R . n 
A 1 339 ASP 339 324 ?   ?   ?   R . n 
A 1 340 GLY 340 325 ?   ?   ?   R . n 
A 1 341 LYS 341 326 ?   ?   ?   R . n 
A 1 342 VAL 342 327 ?   ?   ?   R . n 
A 1 343 GLN 343 328 ?   ?   ?   R . n 
A 1 344 VAL 344 329 ?   ?   ?   R . n 
A 1 345 THR 345 330 ?   ?   ?   R . n 
A 1 346 ARG 346 331 ?   ?   ?   R . n 
A 1 347 PRO 347 332 ?   ?   ?   R . n 
A 1 348 ASP 348 333 ?   ?   ?   R . n 
A 1 349 GLN 349 334 ?   ?   ?   R . n 
A 1 350 ALA 350 335 335 ALA ALA R . n 
A 1 351 ARG 351 336 336 ARG ARG R . n 
A 1 352 MET 352 337 337 MET MET R . n 
A 1 353 ASP 353 338 338 ASP ASP R . n 
A 1 354 ILE 354 339 339 ILE ILE R . n 
A 1 355 ARG 355 340 340 ARG ARG R . n 
A 1 356 LEU 356 341 341 LEU LEU R . n 
A 1 357 ALA 357 342 342 ALA ALA R . n 
A 1 358 LYS 358 343 343 LYS LYS R . n 
A 1 359 THR 359 344 344 THR THR R . n 
A 1 360 LEU 360 345 345 LEU LEU R . n 
A 1 361 VAL 361 346 346 VAL VAL R . n 
A 1 362 LEU 362 347 347 LEU LEU R . n 
A 1 363 ILE 363 348 348 ILE ILE R . n 
A 1 364 LEU 364 349 349 LEU LEU R . n 
A 1 365 VAL 365 350 350 VAL VAL R . n 
A 1 366 VAL 366 351 351 VAL VAL R . n 
A 1 367 LEU 367 352 352 LEU LEU R . n 
A 1 368 ILE 368 353 353 ILE ILE R . n 
A 1 369 ILE 369 354 354 ILE ILE R . n 
A 1 370 CYS 370 355 355 CYS CYS R . n 
A 1 371 TRP 371 356 356 TRP TRP R . n 
A 1 372 GLY 372 357 357 GLY GLY R . n 
A 1 373 PRO 373 358 358 PRO PRO R . n 
A 1 374 LEU 374 359 359 LEU LEU R . n 
A 1 375 LEU 375 360 360 LEU LEU R . n 
A 1 376 ALA 376 361 361 ALA ALA R . n 
A 1 377 ILE 377 362 362 ILE ILE R . n 
A 1 378 MET 378 363 363 MET MET R . n 
A 1 379 VAL 379 364 364 VAL VAL R . n 
A 1 380 TYR 380 365 365 TYR TYR R . n 
A 1 381 ASP 381 366 366 ASP ASP R . n 
A 1 382 VAL 382 367 367 VAL VAL R . n 
A 1 383 PHE 383 368 368 PHE PHE R . n 
A 1 384 GLY 384 369 369 GLY GLY R . n 
A 1 385 LYS 385 370 370 LYS LYS R . n 
A 1 386 MET 386 371 371 MET MET R . n 
A 1 387 ASN 387 372 372 ASN ASN R . n 
A 1 388 LYS 388 373 373 LYS LYS R . n 
A 1 389 LEU 389 374 374 LEU LEU R . n 
A 1 390 ILE 390 375 375 ILE ILE R . n 
A 1 391 LYS 391 376 376 LYS LYS R . n 
A 1 392 THR 392 377 377 THR THR R . n 
A 1 393 VAL 393 378 378 VAL VAL R . n 
A 1 394 PHE 394 379 379 PHE PHE R . n 
A 1 395 ALA 395 380 380 ALA ALA R . n 
A 1 396 PHE 396 381 381 PHE PHE R . n 
A 1 397 CYS 397 382 382 CYS CYS R . n 
A 1 398 SER 398 383 383 SER SER R . n 
A 1 399 MET 399 384 384 MET MET R . n 
A 1 400 LEU 400 385 385 LEU LEU R . n 
A 1 401 CYS 401 386 386 CYS CYS R . n 
A 1 402 LEU 402 387 387 LEU LEU R . n 
A 1 403 LEU 403 388 388 LEU LEU R . n 
A 1 404 ASN 404 389 389 ASN ASN R . n 
A 1 405 SER 405 390 390 SER SER R . n 
A 1 406 THR 406 391 391 THR THR R . n 
A 1 407 VAL 407 392 392 VAL VAL R . n 
A 1 408 ASN 408 393 393 ASN ASN R . n 
A 1 409 PRO 409 394 394 PRO PRO R . n 
A 1 410 ILE 410 395 395 ILE ILE R . n 
A 1 411 ILE 411 396 396 ILE ILE R . n 
A 1 412 TYR 412 397 397 TYR TYR R . n 
A 1 413 ALA 413 398 398 ALA ALA R . n 
A 1 414 LEU 414 399 399 LEU LEU R . n 
A 1 415 ARG 415 400 400 ARG ARG R . n 
A 1 416 SER 416 401 401 SER SER R . n 
A 1 417 LYS 417 402 402 LYS LYS R . n 
A 1 418 ASP 418 403 403 ASP ASP R . n 
A 1 419 LEU 419 404 404 LEU LEU R . n 
A 1 420 ARG 420 405 405 ARG ARG R . n 
A 1 421 HIS 421 406 406 HIS HIS R . n 
A 1 422 ALA 422 407 407 ALA ALA R . n 
A 1 423 PHE 423 408 408 PHE PHE R . n 
A 1 424 ARG 424 409 409 ARG ARG R . n 
A 1 425 SER 425 410 410 SER SER R . n 
A 1 426 MET 426 411 411 MET MET R . n 
A 1 427 PHE 427 412 ?   ?   ?   R . n 
A 1 428 PRO 428 413 ?   ?   ?   R . n 
A 1 429 SER 429 414 ?   ?   ?   R . n 
A 1 430 CYS 430 415 ?   ?   ?   R . n 
A 1 431 GLU 431 416 ?   ?   ?   R . n 
A 1 432 GLY 432 417 ?   ?   ?   R . n 
A 1 433 THR 433 418 ?   ?   ?   R . n 
A 1 434 ALA 434 419 ?   ?   ?   R . n 
A 1 435 GLN 435 420 ?   ?   ?   R . n 
A 1 436 PRO 436 421 ?   ?   ?   R . n 
A 1 437 LEU 437 422 ?   ?   ?   R . n 
A 1 438 ASP 438 423 ?   ?   ?   R . n 
A 1 439 ASN 439 424 ?   ?   ?   R . n 
A 1 440 SER 440 425 ?   ?   ?   R . n 
A 1 441 MET 441 426 ?   ?   ?   R . n 
A 1 442 GLY 442 427 ?   ?   ?   R . n 
A 1 443 ASP 443 428 ?   ?   ?   R . n 
A 1 444 SER 444 429 ?   ?   ?   R . n 
A 1 445 ASP 445 430 ?   ?   ?   R . n 
A 1 446 CYS 446 431 ?   ?   ?   R . n 
A 1 447 LEU 447 432 ?   ?   ?   R . n 
A 1 448 HIS 448 433 ?   ?   ?   R . n 
A 1 449 LYS 449 434 ?   ?   ?   R . n 
A 1 450 HIS 450 435 ?   ?   ?   R . n 
A 1 451 ALA 451 436 ?   ?   ?   R . n 
A 1 452 ASN 452 437 ?   ?   ?   R . n 
A 1 453 ASN 453 438 ?   ?   ?   R . n 
A 1 454 ALA 454 439 ?   ?   ?   R . n 
A 1 455 ALA 455 440 ?   ?   ?   R . n 
A 1 456 SER 456 441 ?   ?   ?   R . n 
A 1 457 VAL 457 442 ?   ?   ?   R . n 
A 1 458 HIS 458 443 ?   ?   ?   R . n 
A 1 459 ARG 459 444 ?   ?   ?   R . n 
A 1 460 ALA 460 445 ?   ?   ?   R . n 
A 1 461 ALA 461 446 ?   ?   ?   R . n 
A 1 462 GLU 462 447 ?   ?   ?   R . n 
A 1 463 SER 463 448 ?   ?   ?   R . n 
A 1 464 CYS 464 449 ?   ?   ?   R . n 
A 1 465 ILE 465 450 ?   ?   ?   R . n 
A 1 466 LYS 466 451 ?   ?   ?   R . n 
A 1 467 SER 467 452 ?   ?   ?   R . n 
A 1 468 THR 468 453 ?   ?   ?   R . n 
A 1 469 VAL 469 454 ?   ?   ?   R . n 
A 1 470 LYS 470 455 ?   ?   ?   R . n 
A 1 471 ILE 471 456 ?   ?   ?   R . n 
A 1 472 ALA 472 457 ?   ?   ?   R . n 
A 1 473 LYS 473 458 ?   ?   ?   R . n 
A 1 474 VAL 474 459 ?   ?   ?   R . n 
A 1 475 THR 475 460 ?   ?   ?   R . n 
A 1 476 MET 476 461 ?   ?   ?   R . n 
A 1 477 SER 477 462 ?   ?   ?   R . n 
A 1 478 VAL 478 463 ?   ?   ?   R . n 
A 1 479 SER 479 464 ?   ?   ?   R . n 
A 1 480 THR 480 465 ?   ?   ?   R . n 
A 1 481 ASP 481 466 ?   ?   ?   R . n 
A 1 482 THR 482 467 ?   ?   ?   R . n 
A 1 483 SER 483 468 ?   ?   ?   R . n 
A 1 484 ALA 484 469 ?   ?   ?   R . n 
A 1 485 GLU 485 470 ?   ?   ?   R . n 
A 1 486 ALA 486 471 ?   ?   ?   R . n 
A 1 487 LEU 487 472 ?   ?   ?   R . n 
A 1 488 GLY 488 473 ?   ?   ?   R . n 
A 1 489 SER 489 474 ?   ?   ?   R . n 
A 1 490 HIS 490 475 ?   ?   ?   R . n 
A 1 491 HIS 491 476 ?   ?   ?   R . n 
A 1 492 HIS 492 477 ?   ?   ?   R . n 
A 1 493 HIS 493 478 ?   ?   ?   R . n 
A 1 494 HIS 494 479 ?   ?   ?   R . n 
A 1 495 HIS 495 480 ?   ?   ?   R . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        YVF 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   YVF 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         B 
_pdbx_nonpoly_scheme.entity_id       2 
_pdbx_nonpoly_scheme.mon_id          YVF 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     501 
_pdbx_nonpoly_scheme.auth_seq_num    501 
_pdbx_nonpoly_scheme.pdb_mon_id      YVF 
_pdbx_nonpoly_scheme.auth_mon_id     TAT 
_pdbx_nonpoly_scheme.pdb_strand_id   R 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 R ASN 112 ? CG  ? A ASN 127 CG  
2   1 Y 1 R ASN 112 ? OD1 ? A ASN 127 OD1 
3   1 Y 1 R ASN 112 ? ND2 ? A ASN 127 ND2 
4   1 Y 1 R SER 114 ? OG  ? A SER 129 OG  
5   1 Y 1 R GLN 115 ? CG  ? A GLN 130 CG  
6   1 Y 1 R GLN 115 ? CD  ? A GLN 130 CD  
7   1 Y 1 R GLN 115 ? OE1 ? A GLN 130 OE1 
8   1 Y 1 R GLN 115 ? NE2 ? A GLN 130 NE2 
9   1 Y 1 R GLN 116 ? CG  ? A GLN 131 CG  
10  1 Y 1 R GLN 116 ? CD  ? A GLN 131 CD  
11  1 Y 1 R GLN 116 ? OE1 ? A GLN 131 OE1 
12  1 Y 1 R GLN 116 ? NE2 ? A GLN 131 NE2 
13  1 Y 1 R LEU 117 ? CG  ? A LEU 132 CG  
14  1 Y 1 R LEU 117 ? CD1 ? A LEU 132 CD1 
15  1 Y 1 R LEU 117 ? CD2 ? A LEU 132 CD2 
16  1 Y 1 R VAL 121 ? CG1 ? A VAL 136 CG1 
17  1 Y 1 R VAL 121 ? CG2 ? A VAL 136 CG2 
18  1 Y 1 R LEU 124 ? CG  ? A LEU 139 CG  
19  1 Y 1 R LEU 124 ? CD1 ? A LEU 139 CD1 
20  1 Y 1 R LEU 124 ? CD2 ? A LEU 139 CD2 
21  1 Y 1 R LEU 132 ? CG  ? A LEU 147 CG  
22  1 Y 1 R LEU 132 ? CD1 ? A LEU 147 CD1 
23  1 Y 1 R LEU 132 ? CD2 ? A LEU 147 CD2 
24  1 Y 1 R ASP 163 ? CG  ? A ASP 178 CG  
25  1 Y 1 R ASP 163 ? OD1 ? A ASP 178 OD1 
26  1 Y 1 R ASP 163 ? OD2 ? A ASP 178 OD2 
27  1 Y 1 R LYS 183 ? CG  ? A LYS 198 CG  
28  1 Y 1 R LYS 183 ? CD  ? A LYS 198 CD  
29  1 Y 1 R LYS 183 ? CE  ? A LYS 198 CE  
30  1 Y 1 R LYS 183 ? NZ  ? A LYS 198 NZ  
31  1 Y 1 R ASP 184 ? CG  ? A ASP 199 CG  
32  1 Y 1 R ASP 184 ? OD1 ? A ASP 199 OD1 
33  1 Y 1 R ASP 184 ? OD2 ? A ASP 199 OD2 
34  1 Y 1 R ARG 186 ? CG  ? A ARG 201 CG  
35  1 Y 1 R ARG 186 ? CD  ? A ARG 201 CD  
36  1 Y 1 R ARG 186 ? NE  ? A ARG 201 NE  
37  1 Y 1 R ARG 186 ? CZ  ? A ARG 201 CZ  
38  1 Y 1 R ARG 186 ? NH1 ? A ARG 201 NH1 
39  1 Y 1 R ARG 186 ? NH2 ? A ARG 201 NH2 
40  1 Y 1 R ASN 187 ? CG  ? A ASN 202 CG  
41  1 Y 1 R ASN 187 ? OD1 ? A ASN 202 OD1 
42  1 Y 1 R ASN 187 ? ND2 ? A ASN 202 ND2 
43  1 Y 1 R LYS 225 ? CG  ? A LYS 240 CG  
44  1 Y 1 R LYS 225 ? CD  ? A LYS 240 CD  
45  1 Y 1 R LYS 225 ? CE  ? A LYS 240 CE  
46  1 Y 1 R LYS 225 ? NZ  ? A LYS 240 NZ  
47  1 Y 1 R THR 229 ? OG1 ? A THR 244 OG1 
48  1 Y 1 R THR 229 ? CG2 ? A THR 244 CG2 
49  1 Y 1 R THR 242 ? OG1 ? A THR 257 OG1 
50  1 Y 1 R THR 242 ? CG2 ? A THR 257 CG2 
51  1 Y 1 R VAL 246 ? CG1 ? A VAL 261 CG1 
52  1 Y 1 R VAL 246 ? CG2 ? A VAL 261 CG2 
53  1 Y 1 R ILE 247 ? CG1 ? A ILE 262 CG1 
54  1 Y 1 R ILE 247 ? CG2 ? A ILE 262 CG2 
55  1 Y 1 R ILE 247 ? CD1 ? A ILE 262 CD1 
56  1 Y 1 R GLU 273 ? CG  ? A GLU 288 CG  
57  1 Y 1 R GLU 273 ? CD  ? A GLU 288 CD  
58  1 Y 1 R GLU 273 ? OE1 ? A GLU 288 OE1 
59  1 Y 1 R GLU 273 ? OE2 ? A GLU 288 OE2 
60  1 Y 1 R THR 274 ? OG1 ? A THR 289 OG1 
61  1 Y 1 R THR 274 ? CG2 ? A THR 289 CG2 
62  1 Y 1 R MET 277 ? CG  ? A MET 292 CG  
63  1 Y 1 R MET 277 ? SD  ? A MET 292 SD  
64  1 Y 1 R MET 277 ? CE  ? A MET 292 CE  
65  1 Y 1 R GLN 310 ? CG  ? A GLN 325 CG  
66  1 Y 1 R GLN 310 ? CD  ? A GLN 325 CD  
67  1 Y 1 R GLN 310 ? OE1 ? A GLN 325 OE1 
68  1 Y 1 R GLN 310 ? NE2 ? A GLN 325 NE2 
69  1 Y 1 R PHE 368 ? CG  ? A PHE 383 CG  
70  1 Y 1 R PHE 368 ? CD1 ? A PHE 383 CD1 
71  1 Y 1 R PHE 368 ? CD2 ? A PHE 383 CD2 
72  1 Y 1 R PHE 368 ? CE1 ? A PHE 383 CE1 
73  1 Y 1 R PHE 368 ? CE2 ? A PHE 383 CE2 
74  1 Y 1 R PHE 368 ? CZ  ? A PHE 383 CZ  
75  1 Y 1 R LYS 370 ? CG  ? A LYS 385 CG  
76  1 Y 1 R LYS 370 ? CD  ? A LYS 385 CD  
77  1 Y 1 R LYS 370 ? CE  ? A LYS 385 CE  
78  1 Y 1 R LYS 370 ? NZ  ? A LYS 385 NZ  
79  1 Y 1 R MET 371 ? CG  ? A MET 386 CG  
80  1 Y 1 R MET 371 ? SD  ? A MET 386 SD  
81  1 Y 1 R MET 371 ? CE  ? A MET 386 CE  
82  1 Y 1 R ASN 372 ? CG  ? A ASN 387 CG  
83  1 Y 1 R ASN 372 ? OD1 ? A ASN 387 OD1 
84  1 Y 1 R ASN 372 ? ND2 ? A ASN 387 ND2 
85  1 Y 1 R LYS 373 ? CG  ? A LYS 388 CG  
86  1 Y 1 R LYS 373 ? CD  ? A LYS 388 CD  
87  1 Y 1 R LYS 373 ? CE  ? A LYS 388 CE  
88  1 Y 1 R LYS 373 ? NZ  ? A LYS 388 NZ  
89  1 Y 1 R LEU 374 ? CG  ? A LEU 389 CG  
90  1 Y 1 R LEU 374 ? CD1 ? A LEU 389 CD1 
91  1 Y 1 R LEU 374 ? CD2 ? A LEU 389 CD2 
92  1 Y 1 R THR 377 ? OG1 ? A THR 392 OG1 
93  1 Y 1 R THR 377 ? CG2 ? A THR 392 CG2 
94  1 Y 1 R LYS 402 ? CG  ? A LYS 417 CG  
95  1 Y 1 R LYS 402 ? CD  ? A LYS 417 CD  
96  1 Y 1 R LYS 402 ? CE  ? A LYS 417 CE  
97  1 Y 1 R LYS 402 ? NZ  ? A LYS 417 NZ  
98  1 Y 1 R MET 411 ? CG  ? A MET 426 CG  
99  1 Y 1 R MET 411 ? SD  ? A MET 426 SD  
100 1 Y 1 R MET 411 ? CE  ? A MET 426 CE  
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DGI 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9DGI 
_struct.title                        'Cannabinoid receptor 1-Gi complex with novel ligand' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DGI 
_struct_keywords.text            'GPCR, G protein, Gi, cannabinoid receptor, CB1, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    CNR1_HUMAN 
_struct_ref.pdbx_db_accession          P21554 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITE
FYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLA
VADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIH
TSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALR
SKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9DGI 
_struct_ref_seq.pdbx_strand_id                R 
_struct_ref_seq.seq_align_beg                 9 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 487 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P21554 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  472 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -6 
_struct_ref_seq.pdbx_auth_seq_align_end       472 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DGI ASP R 1   ? UNP P21554 ? ? 'expression tag' -14 1  
1 9DGI TYR R 2   ? UNP P21554 ? ? 'expression tag' -13 2  
1 9DGI LYS R 3   ? UNP P21554 ? ? 'expression tag' -12 3  
1 9DGI ASP R 4   ? UNP P21554 ? ? 'expression tag' -11 4  
1 9DGI ASP R 5   ? UNP P21554 ? ? 'expression tag' -10 5  
1 9DGI ASP R 6   ? UNP P21554 ? ? 'expression tag' -9  6  
1 9DGI ASP R 7   ? UNP P21554 ? ? 'expression tag' -8  7  
1 9DGI ALA R 8   ? UNP P21554 ? ? 'expression tag' -7  8  
1 9DGI GLU R 96  ? UNP P21554 ? ? insertion        81  9  
1 9DGI ASN R 97  ? UNP P21554 ? ? insertion        82  10 
1 9DGI LEU R 98  ? UNP P21554 ? ? insertion        83  11 
1 9DGI TYR R 99  ? UNP P21554 ? ? insertion        84  12 
1 9DGI PHE R 100 ? UNP P21554 ? ? insertion        85  13 
1 9DGI GLN R 101 ? UNP P21554 ? ? insertion        86  14 
1 9DGI GLY R 102 ? UNP P21554 ? ? insertion        87  15 
1 9DGI GLY R 488 ? UNP P21554 ? ? 'expression tag' 473 16 
1 9DGI SER R 489 ? UNP P21554 ? ? 'expression tag' 474 17 
1 9DGI HIS R 490 ? UNP P21554 ? ? 'expression tag' 475 18 
1 9DGI HIS R 491 ? UNP P21554 ? ? 'expression tag' 476 19 
1 9DGI HIS R 492 ? UNP P21554 ? ? 'expression tag' 477 20 
1 9DGI HIS R 493 ? UNP P21554 ? ? 'expression tag' 478 21 
1 9DGI HIS R 494 ? UNP P21554 ? ? 'expression tag' 479 22 
1 9DGI HIS R 495 ? UNP P21554 ? ? 'expression tag' 480 23 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 133 ? SER A 138 ? ALA R 118 SER R 123 1 ? 6  
HELX_P HELX_P2  AA2 THR A 143 ? LEU A 150 ? THR R 128 LEU R 135 1 ? 8  
HELX_P HELX_P3  AA3 LEU A 151 ? VAL A 155 ? LEU R 136 VAL R 140 5 ? 5  
HELX_P HELX_P4  AA4 VAL A 183 ? HIS A 193 ? VAL R 168 HIS R 178 1 ? 11 
HELX_P HELX_P5  AA5 VAL A 203 ? LEU A 208 ? VAL R 188 LEU R 193 1 ? 6  
HELX_P HELX_P6  AA6 LEU A 208 ? ALA A 213 ? LEU R 193 ALA R 198 1 ? 6  
HELX_P HELX_P7  AA7 LEU A 224 ? ARG A 229 ? LEU R 209 ARG R 214 1 ? 6  
HELX_P HELX_P8  AA8 THR A 244 ? ALA A 248 ? THR R 229 ALA R 233 5 ? 5  
HELX_P HELX_P9  AA9 PHE A 252 ? THR A 257 ? PHE R 237 THR R 242 1 ? 6  
HELX_P HELX_P10 AB1 TRP A 294 ? SER A 299 ? TRP R 279 SER R 284 1 ? 6  
HELX_P HELX_P11 AB2 TYR A 311 ? ARG A 326 ? TYR R 296 ARG R 311 1 ? 16 
HELX_P HELX_P12 AB3 PRO A 373 ? ASP A 381 ? PRO R 358 ASP R 366 1 ? 9  
HELX_P HELX_P13 AB4 SER A 398 ? LEU A 403 ? SER R 383 LEU R 388 5 ? 6  
HELX_P HELX_P14 AB5 VAL A 407 ? TYR A 412 ? VAL R 392 TYR R 397 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   9DGI 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             CA 
_pdbx_validate_rmsd_angle.auth_asym_id_1             R 
_pdbx_validate_rmsd_angle.auth_comp_id_1             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_1              111 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CB 
_pdbx_validate_rmsd_angle.auth_asym_id_2             R 
_pdbx_validate_rmsd_angle.auth_comp_id_2             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_2              111 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             CG 
_pdbx_validate_rmsd_angle.auth_asym_id_3             R 
_pdbx_validate_rmsd_angle.auth_comp_id_3             LEU 
_pdbx_validate_rmsd_angle.auth_seq_id_3              111 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                130.59 
_pdbx_validate_rmsd_angle.angle_target_value         115.30 
_pdbx_validate_rmsd_angle.angle_deviation            15.29 
_pdbx_validate_rmsd_angle.angle_standard_deviation   2.30 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 LEU R 111 ? ? -105.59 -61.03 
2 1 PRO R 151 ? ? -65.66  6.29   
3 1 HIS R 178 ? ? -99.21  -61.32 
4 1 PHE R 180 ? ? -24.36  123.66 
5 1 PRO R 251 ? ? -67.60  27.27  
6 1 HIS R 270 ? ? -101.13 54.90  
7 1 ILE R 309 ? ? -130.29 -52.53 
8 1 ASN R 389 ? ? -92.68  45.94  
9 1 PRO R 394 ? ? -87.72  42.98  
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   VAL 
_pdbx_validate_peptide_omega.auth_asym_id_1   R 
_pdbx_validate_peptide_omega.auth_seq_id_1    179 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   PHE 
_pdbx_validate_peptide_omega.auth_asym_id_2   R 
_pdbx_validate_peptide_omega.auth_seq_id_2    180 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            -134.23 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9DGI 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9DGI 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.35 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               465411 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Signaling complex of the cannabinoid receptor 1 bound to Gi' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9DGI 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             700 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9DGI 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9DGI 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 R ASP -14 ? A ASP 1   
2   1 Y 1 R TYR -13 ? A TYR 2   
3   1 Y 1 R LYS -12 ? A LYS 3   
4   1 Y 1 R ASP -11 ? A ASP 4   
5   1 Y 1 R ASP -10 ? A ASP 5   
6   1 Y 1 R ASP -9  ? A ASP 6   
7   1 Y 1 R ASP -8  ? A ASP 7   
8   1 Y 1 R ALA -7  ? A ALA 8   
9   1 Y 1 R MET -6  ? A MET 9   
10  1 Y 1 R LYS -5  ? A LYS 10  
11  1 Y 1 R SER -4  ? A SER 11  
12  1 Y 1 R ILE -3  ? A ILE 12  
13  1 Y 1 R LEU -2  ? A LEU 13  
14  1 Y 1 R ASP -1  ? A ASP 14  
15  1 Y 1 R GLY 0   ? A GLY 15  
16  1 Y 1 R LEU 1   ? A LEU 16  
17  1 Y 1 R ALA 2   ? A ALA 17  
18  1 Y 1 R ASP 3   ? A ASP 18  
19  1 Y 1 R THR 4   ? A THR 19  
20  1 Y 1 R THR 5   ? A THR 20  
21  1 Y 1 R PHE 6   ? A PHE 21  
22  1 Y 1 R ARG 7   ? A ARG 22  
23  1 Y 1 R THR 8   ? A THR 23  
24  1 Y 1 R ILE 9   ? A ILE 24  
25  1 Y 1 R THR 10  ? A THR 25  
26  1 Y 1 R THR 11  ? A THR 26  
27  1 Y 1 R ASP 12  ? A ASP 27  
28  1 Y 1 R LEU 13  ? A LEU 28  
29  1 Y 1 R LEU 14  ? A LEU 29  
30  1 Y 1 R TYR 15  ? A TYR 30  
31  1 Y 1 R VAL 16  ? A VAL 31  
32  1 Y 1 R GLY 17  ? A GLY 32  
33  1 Y 1 R SER 18  ? A SER 33  
34  1 Y 1 R ASN 19  ? A ASN 34  
35  1 Y 1 R ASP 20  ? A ASP 35  
36  1 Y 1 R ILE 21  ? A ILE 36  
37  1 Y 1 R GLN 22  ? A GLN 37  
38  1 Y 1 R TYR 23  ? A TYR 38  
39  1 Y 1 R GLU 24  ? A GLU 39  
40  1 Y 1 R ASP 25  ? A ASP 40  
41  1 Y 1 R ILE 26  ? A ILE 41  
42  1 Y 1 R LYS 27  ? A LYS 42  
43  1 Y 1 R GLY 28  ? A GLY 43  
44  1 Y 1 R ASP 29  ? A ASP 44  
45  1 Y 1 R MET 30  ? A MET 45  
46  1 Y 1 R ALA 31  ? A ALA 46  
47  1 Y 1 R SER 32  ? A SER 47  
48  1 Y 1 R LYS 33  ? A LYS 48  
49  1 Y 1 R LEU 34  ? A LEU 49  
50  1 Y 1 R GLY 35  ? A GLY 50  
51  1 Y 1 R TYR 36  ? A TYR 51  
52  1 Y 1 R PHE 37  ? A PHE 52  
53  1 Y 1 R PRO 38  ? A PRO 53  
54  1 Y 1 R GLN 39  ? A GLN 54  
55  1 Y 1 R LYS 40  ? A LYS 55  
56  1 Y 1 R PHE 41  ? A PHE 56  
57  1 Y 1 R PRO 42  ? A PRO 57  
58  1 Y 1 R LEU 43  ? A LEU 58  
59  1 Y 1 R THR 44  ? A THR 59  
60  1 Y 1 R SER 45  ? A SER 60  
61  1 Y 1 R PHE 46  ? A PHE 61  
62  1 Y 1 R ARG 47  ? A ARG 62  
63  1 Y 1 R GLY 48  ? A GLY 63  
64  1 Y 1 R SER 49  ? A SER 64  
65  1 Y 1 R PRO 50  ? A PRO 65  
66  1 Y 1 R PHE 51  ? A PHE 66  
67  1 Y 1 R GLN 52  ? A GLN 67  
68  1 Y 1 R GLU 53  ? A GLU 68  
69  1 Y 1 R LYS 54  ? A LYS 69  
70  1 Y 1 R MET 55  ? A MET 70  
71  1 Y 1 R THR 56  ? A THR 71  
72  1 Y 1 R ALA 57  ? A ALA 72  
73  1 Y 1 R GLY 58  ? A GLY 73  
74  1 Y 1 R ASP 59  ? A ASP 74  
75  1 Y 1 R ASN 60  ? A ASN 75  
76  1 Y 1 R PRO 61  ? A PRO 76  
77  1 Y 1 R GLN 62  ? A GLN 77  
78  1 Y 1 R LEU 63  ? A LEU 78  
79  1 Y 1 R VAL 64  ? A VAL 79  
80  1 Y 1 R PRO 65  ? A PRO 80  
81  1 Y 1 R ALA 66  ? A ALA 81  
82  1 Y 1 R ASP 67  ? A ASP 82  
83  1 Y 1 R GLN 68  ? A GLN 83  
84  1 Y 1 R VAL 69  ? A VAL 84  
85  1 Y 1 R ASN 70  ? A ASN 85  
86  1 Y 1 R ILE 71  ? A ILE 86  
87  1 Y 1 R THR 72  ? A THR 87  
88  1 Y 1 R GLU 73  ? A GLU 88  
89  1 Y 1 R PHE 74  ? A PHE 89  
90  1 Y 1 R TYR 75  ? A TYR 90  
91  1 Y 1 R ASN 76  ? A ASN 91  
92  1 Y 1 R LYS 77  ? A LYS 92  
93  1 Y 1 R SER 78  ? A SER 93  
94  1 Y 1 R LEU 79  ? A LEU 94  
95  1 Y 1 R SER 80  ? A SER 95  
96  1 Y 1 R GLU 81  ? A GLU 96  
97  1 Y 1 R ASN 82  ? A ASN 97  
98  1 Y 1 R LEU 83  ? A LEU 98  
99  1 Y 1 R TYR 84  ? A TYR 99  
100 1 Y 1 R PHE 85  ? A PHE 100 
101 1 Y 1 R GLN 86  ? A GLN 101 
102 1 Y 1 R GLY 87  ? A GLY 102 
103 1 Y 1 R SER 88  ? A SER 103 
104 1 Y 1 R PHE 89  ? A PHE 104 
105 1 Y 1 R LYS 90  ? A LYS 105 
106 1 Y 1 R GLU 91  ? A GLU 106 
107 1 Y 1 R ASN 92  ? A ASN 107 
108 1 Y 1 R GLU 93  ? A GLU 108 
109 1 Y 1 R GLU 94  ? A GLU 109 
110 1 Y 1 R ASN 95  ? A ASN 110 
111 1 Y 1 R ILE 96  ? A ILE 111 
112 1 Y 1 R GLN 97  ? A GLN 112 
113 1 Y 1 R CYS 98  ? A CYS 113 
114 1 Y 1 R GLY 99  ? A GLY 114 
115 1 Y 1 R GLU 100 ? A GLU 115 
116 1 Y 1 R ASN 101 ? A ASN 116 
117 1 Y 1 R PHE 102 ? A PHE 117 
118 1 Y 1 R MET 103 ? A MET 118 
119 1 Y 1 R ASP 104 ? A ASP 119 
120 1 Y 1 R ILE 105 ? A ILE 120 
121 1 Y 1 R GLU 106 ? A GLU 121 
122 1 Y 1 R CYS 107 ? A CYS 122 
123 1 Y 1 R LEU 142 ? A LEU 157 
124 1 Y 1 R HIS 143 ? A HIS 158 
125 1 Y 1 R SER 144 ? A SER 159 
126 1 Y 1 R ARG 145 ? A ARG 160 
127 1 Y 1 R SER 146 ? A SER 161 
128 1 Y 1 R LEU 147 ? A LEU 162 
129 1 Y 1 R GLY 254 ? A GLY 269 
130 1 Y 1 R TRP 255 ? A TRP 270 
131 1 Y 1 R ASN 256 ? A ASN 271 
132 1 Y 1 R CYS 257 ? A CYS 272 
133 1 Y 1 R GLU 258 ? A GLU 273 
134 1 Y 1 R LYS 259 ? A LYS 274 
135 1 Y 1 R LEU 260 ? A LEU 275 
136 1 Y 1 R GLN 261 ? A GLN 276 
137 1 Y 1 R SER 262 ? A SER 277 
138 1 Y 1 R VAL 263 ? A VAL 278 
139 1 Y 1 R CYS 264 ? A CYS 279 
140 1 Y 1 R SER 265 ? A SER 280 
141 1 Y 1 R GLN 314 ? A GLN 329 
142 1 Y 1 R LYS 315 ? A LYS 330 
143 1 Y 1 R SER 316 ? A SER 331 
144 1 Y 1 R ILE 317 ? A ILE 332 
145 1 Y 1 R ILE 318 ? A ILE 333 
146 1 Y 1 R ILE 319 ? A ILE 334 
147 1 Y 1 R HIS 320 ? A HIS 335 
148 1 Y 1 R THR 321 ? A THR 336 
149 1 Y 1 R SER 322 ? A SER 337 
150 1 Y 1 R GLU 323 ? A GLU 338 
151 1 Y 1 R ASP 324 ? A ASP 339 
152 1 Y 1 R GLY 325 ? A GLY 340 
153 1 Y 1 R LYS 326 ? A LYS 341 
154 1 Y 1 R VAL 327 ? A VAL 342 
155 1 Y 1 R GLN 328 ? A GLN 343 
156 1 Y 1 R VAL 329 ? A VAL 344 
157 1 Y 1 R THR 330 ? A THR 345 
158 1 Y 1 R ARG 331 ? A ARG 346 
159 1 Y 1 R PRO 332 ? A PRO 347 
160 1 Y 1 R ASP 333 ? A ASP 348 
161 1 Y 1 R GLN 334 ? A GLN 349 
162 1 Y 1 R PHE 412 ? A PHE 427 
163 1 Y 1 R PRO 413 ? A PRO 428 
164 1 Y 1 R SER 414 ? A SER 429 
165 1 Y 1 R CYS 415 ? A CYS 430 
166 1 Y 1 R GLU 416 ? A GLU 431 
167 1 Y 1 R GLY 417 ? A GLY 432 
168 1 Y 1 R THR 418 ? A THR 433 
169 1 Y 1 R ALA 419 ? A ALA 434 
170 1 Y 1 R GLN 420 ? A GLN 435 
171 1 Y 1 R PRO 421 ? A PRO 436 
172 1 Y 1 R LEU 422 ? A LEU 437 
173 1 Y 1 R ASP 423 ? A ASP 438 
174 1 Y 1 R ASN 424 ? A ASN 439 
175 1 Y 1 R SER 425 ? A SER 440 
176 1 Y 1 R MET 426 ? A MET 441 
177 1 Y 1 R GLY 427 ? A GLY 442 
178 1 Y 1 R ASP 428 ? A ASP 443 
179 1 Y 1 R SER 429 ? A SER 444 
180 1 Y 1 R ASP 430 ? A ASP 445 
181 1 Y 1 R CYS 431 ? A CYS 446 
182 1 Y 1 R LEU 432 ? A LEU 447 
183 1 Y 1 R HIS 433 ? A HIS 448 
184 1 Y 1 R LYS 434 ? A LYS 449 
185 1 Y 1 R HIS 435 ? A HIS 450 
186 1 Y 1 R ALA 436 ? A ALA 451 
187 1 Y 1 R ASN 437 ? A ASN 452 
188 1 Y 1 R ASN 438 ? A ASN 453 
189 1 Y 1 R ALA 439 ? A ALA 454 
190 1 Y 1 R ALA 440 ? A ALA 455 
191 1 Y 1 R SER 441 ? A SER 456 
192 1 Y 1 R VAL 442 ? A VAL 457 
193 1 Y 1 R HIS 443 ? A HIS 458 
194 1 Y 1 R ARG 444 ? A ARG 459 
195 1 Y 1 R ALA 445 ? A ALA 460 
196 1 Y 1 R ALA 446 ? A ALA 461 
197 1 Y 1 R GLU 447 ? A GLU 462 
198 1 Y 1 R SER 448 ? A SER 463 
199 1 Y 1 R CYS 449 ? A CYS 464 
200 1 Y 1 R ILE 450 ? A ILE 465 
201 1 Y 1 R LYS 451 ? A LYS 466 
202 1 Y 1 R SER 452 ? A SER 467 
203 1 Y 1 R THR 453 ? A THR 468 
204 1 Y 1 R VAL 454 ? A VAL 469 
205 1 Y 1 R LYS 455 ? A LYS 470 
206 1 Y 1 R ILE 456 ? A ILE 471 
207 1 Y 1 R ALA 457 ? A ALA 472 
208 1 Y 1 R LYS 458 ? A LYS 473 
209 1 Y 1 R VAL 459 ? A VAL 474 
210 1 Y 1 R THR 460 ? A THR 475 
211 1 Y 1 R MET 461 ? A MET 476 
212 1 Y 1 R SER 462 ? A SER 477 
213 1 Y 1 R VAL 463 ? A VAL 478 
214 1 Y 1 R SER 464 ? A SER 479 
215 1 Y 1 R THR 465 ? A THR 480 
216 1 Y 1 R ASP 466 ? A ASP 481 
217 1 Y 1 R THR 467 ? A THR 482 
218 1 Y 1 R SER 468 ? A SER 483 
219 1 Y 1 R ALA 469 ? A ALA 484 
220 1 Y 1 R GLU 470 ? A GLU 485 
221 1 Y 1 R ALA 471 ? A ALA 486 
222 1 Y 1 R LEU 472 ? A LEU 487 
223 1 Y 1 R GLY 473 ? A GLY 488 
224 1 Y 1 R SER 474 ? A SER 489 
225 1 Y 1 R HIS 475 ? A HIS 490 
226 1 Y 1 R HIS 476 ? A HIS 491 
227 1 Y 1 R HIS 477 ? A HIS 492 
228 1 Y 1 R HIS 478 ? A HIS 493 
229 1 Y 1 R HIS 479 ? A HIS 494 
230 1 Y 1 R HIS 480 ? A HIS 495 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
YVF C01  C N N 388 
YVF C03  C N N 389 
YVF C04  C N R 390 
YVF C05  C Y N 391 
YVF C06  C Y N 392 
YVF C07  C Y N 393 
YVF C08  C Y N 394 
YVF C10  C N N 395 
YVF C12  C N N 396 
YVF C13  C Y N 397 
YVF C16  C Y N 398 
YVF C17  C Y N 399 
YVF C18  C Y N 400 
YVF C19  C N N 401 
YVF C23  C Y N 402 
YVF C24  C Y N 403 
YVF C25  C Y N 404 
YVF C26  C Y N 405 
YVF C27  C N N 406 
YVF C28  C Y N 407 
YVF F20  F N N 408 
YVF F21  F N N 409 
YVF F22  F N N 410 
YVF N11  N N N 411 
YVF N14  N Y N 412 
YVF N15  N Y N 413 
YVF O02  O N N 414 
YVF O29  O N N 415 
YVF O30  O N N 416 
YVF S09  S Y N 417 
YVF H1   H N N 418 
YVF H2   H N N 419 
YVF H3   H N N 420 
YVF H4   H N N 421 
YVF H5   H N N 422 
YVF H6   H N N 423 
YVF H7   H N N 424 
YVF H8   H N N 425 
YVF H9   H N N 426 
YVF H10  H N N 427 
YVF H11  H N N 428 
YVF H12  H N N 429 
YVF H13  H N N 430 
YVF H14  H N N 431 
YVF H15  H N N 432 
YVF H16  H N N 433 
YVF H17  H N N 434 
YVF H18  H N N 435 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
YVF C24 C25  doub Y N 374 
YVF C24 C23  sing Y N 375 
YVF C25 C16  sing Y N 376 
YVF C23 C18  doub Y N 377 
YVF C08 S09  sing Y N 378 
YVF C08 C07  doub Y N 379 
YVF C16 N15  sing N N 380 
YVF C16 C17  doub Y N 381 
YVF S09 C05  sing Y N 382 
YVF C18 C17  sing Y N 383 
YVF C18 C19  sing N N 384 
YVF C27 C26  sing N N 385 
YVF F22 C19  sing N N 386 
YVF N15 C26  sing Y N 387 
YVF N15 N14  sing Y N 388 
YVF C26 C28  doub Y N 389 
YVF C07 C06  sing Y N 390 
YVF F21 C19  sing N N 391 
YVF C19 F20  sing N N 392 
YVF N14 C13  doub Y N 393 
YVF C28 C13  sing Y N 394 
YVF C05 C06  doub Y N 395 
YVF C05 C04  sing N N 396 
YVF C13 C12  sing N N 397 
YVF N11 C12  sing N N 398 
YVF N11 C04  sing N N 399 
YVF C12 O29  doub N N 400 
YVF C10 C04  sing N N 401 
YVF C04 C03  sing N N 402 
YVF C03 O02  sing N N 403 
YVF C03 O30  doub N N 404 
YVF O02 C01  sing N N 405 
YVF C01 H1   sing N N 406 
YVF C01 H2   sing N N 407 
YVF C01 H3   sing N N 408 
YVF C06 H4   sing N N 409 
YVF C07 H5   sing N N 410 
YVF C08 H6   sing N N 411 
YVF C10 H7   sing N N 412 
YVF C10 H8   sing N N 413 
YVF C10 H9   sing N N 414 
YVF C17 H10  sing N N 415 
YVF C23 H11  sing N N 416 
YVF C24 H12  sing N N 417 
YVF C25 H13  sing N N 418 
YVF C27 H14  sing N N 419 
YVF C27 H15  sing N N 420 
YVF C27 H16  sing N N 421 
YVF C28 H17  sing N N 422 
YVF N11 H18  sing N N 423 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-09-02 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9DGI 
_em_admin.last_update        2025-05-07 
_em_admin.map_release_date   2025-04-30 
_em_admin.title              'Cannabinoid receptor 1-Gi complex with novel ligand' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         56.6 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Defense Advanced Research Projects Agency (DARPA)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           HR0011-19-2-0020 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9DGI 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
F 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 123 ? 123.982 174.261 161.152 1.00 92.90  ?  108 PHE R N   1 
ATOM   2    C CA  . PHE A 1 123 ? 122.786 174.368 161.977 1.00 92.90  ?  108 PHE R CA  1 
ATOM   3    C C   . PHE A 1 123 ? 121.610 173.901 161.120 1.00 92.90  ?  108 PHE R C   1 
ATOM   4    O O   . PHE A 1 123 ? 121.770 173.682 159.923 1.00 92.90  ?  108 PHE R O   1 
ATOM   5    C CB  . PHE A 1 123 ? 122.602 175.808 162.491 1.00 92.90  ?  108 PHE R CB  1 
ATOM   6    C CG  . PHE A 1 123 ? 121.590 175.943 163.604 1.00 92.90  ?  108 PHE R CG  1 
ATOM   7    C CD1 . PHE A 1 123 ? 121.875 175.473 164.883 1.00 92.90  ?  108 PHE R CD1 1 
ATOM   8    C CD2 . PHE A 1 123 ? 120.362 176.554 163.388 1.00 92.90  ?  108 PHE R CD2 1 
ATOM   9    C CE1 . PHE A 1 123 ? 120.958 175.590 165.913 1.00 92.90  ?  108 PHE R CE1 1 
ATOM   10   C CE2 . PHE A 1 123 ? 119.437 176.675 164.416 1.00 92.90  ?  108 PHE R CE2 1 
ATOM   11   C CZ  . PHE A 1 123 ? 119.739 176.192 165.681 1.00 92.90  ?  108 PHE R CZ  1 
ATOM   12   N N   . MET A 1 124 ? 120.430 173.743 161.717 1.00 98.70  ?  109 MET R N   1 
ATOM   13   C CA  . MET A 1 124 ? 119.296 173.111 161.049 1.00 98.70  ?  109 MET R CA  1 
ATOM   14   C C   . MET A 1 124 ? 118.156 174.123 160.866 1.00 98.70  ?  109 MET R C   1 
ATOM   15   O O   . MET A 1 124 ? 117.210 174.192 161.654 1.00 98.70  ?  109 MET R O   1 
ATOM   16   C CB  . MET A 1 124 ? 118.909 171.827 161.820 1.00 98.70  ?  109 MET R CB  1 
ATOM   17   C CG  . MET A 1 124 ? 118.521 171.928 163.327 1.00 98.70  ?  109 MET R CG  1 
ATOM   18   S SD  . MET A 1 124 ? 119.812 172.530 164.442 1.00 98.70  ?  109 MET R SD  1 
ATOM   19   C CE  . MET A 1 124 ? 120.931 171.136 164.532 1.00 98.70  ?  109 MET R CE  1 
ATOM   20   N N   . VAL A 1 125 ? 118.235 174.914 159.793 1.00 100.57 ?  110 VAL R N   1 
ATOM   21   C CA  . VAL A 1 125 ? 117.146 175.811 159.400 1.00 100.57 ?  110 VAL R CA  1 
ATOM   22   C C   . VAL A 1 125 ? 116.940 175.693 157.895 1.00 100.57 ?  110 VAL R C   1 
ATOM   23   O O   . VAL A 1 125 ? 117.749 176.199 157.106 1.00 100.57 ?  110 VAL R O   1 
ATOM   24   C CB  . VAL A 1 125 ? 117.404 177.285 159.790 1.00 100.57 ?  110 VAL R CB  1 
ATOM   25   C CG1 . VAL A 1 125 ? 116.300 178.186 159.230 1.00 100.57 ?  110 VAL R CG1 1 
ATOM   26   C CG2 . VAL A 1 125 ? 117.478 177.475 161.309 1.00 100.57 ?  110 VAL R CG2 1 
ATOM   27   N N   . LEU A 1 126 ? 115.888 174.983 157.480 1.00 102.92 ?  111 LEU R N   1 
ATOM   28   C CA  . LEU A 1 126 ? 115.471 175.062 156.085 1.00 102.92 ?  111 LEU R CA  1 
ATOM   29   C C   . LEU A 1 126 ? 114.199 175.898 155.955 1.00 102.92 ?  111 LEU R C   1 
ATOM   30   O O   . LEU A 1 126 ? 114.234 176.963 155.329 1.00 102.92 ?  111 LEU R O   1 
ATOM   31   C CB  . LEU A 1 126 ? 115.330 173.655 155.471 1.00 102.92 ?  111 LEU R CB  1 
ATOM   32   C CG  . LEU A 1 126 ? 114.260 172.576 155.683 1.00 102.92 ?  111 LEU R CG  1 
ATOM   33   C CD1 . LEU A 1 126 ? 114.387 171.494 154.628 1.00 102.92 ?  111 LEU R CD1 1 
ATOM   34   C CD2 . LEU A 1 126 ? 114.328 171.996 157.077 1.00 102.92 ?  111 LEU R CD2 1 
ATOM   35   N N   . ASN A 1 127 ? 113.100 175.464 156.597 1.00 110.02 ?  112 ASN R N   1 
ATOM   36   C CA  . ASN A 1 127 ? 111.766 176.059 156.578 1.00 110.02 ?  112 ASN R CA  1 
ATOM   37   C C   . ASN A 1 127 ? 110.856 175.222 157.466 1.00 110.02 ?  112 ASN R C   1 
ATOM   38   O O   . ASN A 1 127 ? 111.226 174.104 157.845 1.00 110.02 ?  112 ASN R O   1 
ATOM   39   C CB  . ASN A 1 127 ? 111.180 176.115 155.162 1.00 110.02 ?  112 ASN R CB  1 
ATOM   40   N N   . PRO A 1 128 ? 109.675 175.722 157.835 1.00 113.94 ?  113 PRO R N   1 
ATOM   41   C CA  . PRO A 1 128 ? 108.621 174.817 158.309 1.00 113.94 ?  113 PRO R CA  1 
ATOM   42   C C   . PRO A 1 128 ? 107.744 174.349 157.159 1.00 113.94 ?  113 PRO R C   1 
ATOM   43   O O   . PRO A 1 128 ? 106.937 173.426 157.311 1.00 113.94 ?  113 PRO R O   1 
ATOM   44   C CB  . PRO A 1 128 ? 107.837 175.679 159.303 1.00 113.94 ?  113 PRO R CB  1 
ATOM   45   C CG  . PRO A 1 128 ? 108.011 177.061 158.794 1.00 113.94 ?  113 PRO R CG  1 
ATOM   46   C CD  . PRO A 1 128 ? 109.396 177.124 158.198 1.00 113.94 ?  113 PRO R CD  1 
ATOM   47   N N   . SER A 1 129 ? 107.900 174.990 155.999 1.00 112.80 ?  114 SER R N   1 
ATOM   48   C CA  . SER A 1 129 ? 107.044 174.747 154.844 1.00 112.80 ?  114 SER R CA  1 
ATOM   49   C C   . SER A 1 129 ? 107.665 173.769 153.852 1.00 112.80 ?  114 SER R C   1 
ATOM   50   O O   . SER A 1 129 ? 106.954 172.968 153.238 1.00 112.80 ?  114 SER R O   1 
ATOM   51   C CB  . SER A 1 129 ? 106.726 176.072 154.145 1.00 112.80 ?  114 SER R CB  1 
ATOM   52   N N   . GLN A 1 130 ? 108.984 173.824 153.681 1.00 109.45 ?  115 GLN R N   1 
ATOM   53   C CA  . GLN A 1 130 ? 109.662 172.952 152.731 1.00 109.45 ?  115 GLN R CA  1 
ATOM   54   C C   . GLN A 1 130 ? 110.179 171.691 153.411 1.00 109.45 ?  115 GLN R C   1 
ATOM   55   O O   . GLN A 1 130 ? 111.129 171.069 152.928 1.00 109.45 ?  115 GLN R O   1 
ATOM   56   C CB  . GLN A 1 130 ? 110.814 173.696 152.054 1.00 109.45 ?  115 GLN R CB  1 
ATOM   57   N N   . GLN A 1 131 ? 109.562 171.306 154.534 1.00 104.81 ?  116 GLN R N   1 
ATOM   58   C CA  . GLN A 1 131 ? 109.955 170.108 155.266 1.00 104.81 ?  116 GLN R CA  1 
ATOM   59   C C   . GLN A 1 131 ? 108.828 169.084 155.303 1.00 104.81 ?  116 GLN R C   1 
ATOM   60   O O   . GLN A 1 131 ? 108.766 168.259 156.220 1.00 104.81 ?  116 GLN R O   1 
ATOM   61   C CB  . GLN A 1 131 ? 110.388 170.450 156.694 1.00 104.81 ?  116 GLN R CB  1 
ATOM   62   N N   . LEU A 1 132 ? 107.927 169.121 154.318 1.00 100.27 ?  117 LEU R N   1 
ATOM   63   C CA  . LEU A 1 132 ? 106.811 168.185 154.245 1.00 100.27 ?  117 LEU R CA  1 
ATOM   64   C C   . LEU A 1 132 ? 106.656 167.604 152.847 1.00 100.27 ?  117 LEU R C   1 
ATOM   65   O O   . LEU A 1 132 ? 105.600 167.055 152.523 1.00 100.27 ?  117 LEU R O   1 
ATOM   66   C CB  . LEU A 1 132 ? 105.509 168.859 154.679 1.00 100.27 ?  117 LEU R CB  1 
ATOM   67   N N   . ALA A 1 133 ? 107.682 167.723 152.010 1.00 95.92  ?  118 ALA R N   1 
ATOM   68   C CA  . ALA A 1 133 ? 107.629 167.189 150.658 1.00 95.92  ?  118 ALA R CA  1 
ATOM   69   C C   . ALA A 1 133 ? 108.788 166.235 150.426 1.00 95.92  ?  118 ALA R C   1 
ATOM   70   O O   . ALA A 1 133 ? 108.695 165.330 149.591 1.00 95.92  ?  118 ALA R O   1 
ATOM   71   C CB  . ALA A 1 133 ? 107.654 168.317 149.628 1.00 95.92  ?  118 ALA R CB  1 
ATOM   72   N N   . ILE A 1 134 ? 109.882 166.435 151.159 1.00 93.16  ?  119 ILE R N   1 
ATOM   73   C CA  . ILE A 1 134 ? 111.055 165.573 151.073 1.00 93.16  ?  119 ILE R CA  1 
ATOM   74   C C   . ILE A 1 134 ? 110.697 164.219 151.671 1.00 93.16  ?  119 ILE R C   1 
ATOM   75   O O   . ILE A 1 134 ? 111.169 163.176 151.203 1.00 93.16  ?  119 ILE R O   1 
ATOM   76   C CB  . ILE A 1 134 ? 112.265 166.224 151.772 1.00 93.16  ?  119 ILE R CB  1 
ATOM   77   C CG1 . ILE A 1 134 ? 112.627 167.530 151.068 1.00 93.16  ?  119 ILE R CG1 1 
ATOM   78   C CG2 . ILE A 1 134 ? 113.482 165.320 151.759 1.00 93.16  ?  119 ILE R CG2 1 
ATOM   79   C CD1 . ILE A 1 134 ? 113.685 168.336 151.781 1.00 93.16  ?  119 ILE R CD1 1 
ATOM   80   N N   . ALA A 1 135 ? 109.801 164.220 152.662 1.00 95.38  ?  120 ALA R N   1 
ATOM   81   C CA  . ALA A 1 135 ? 109.318 162.973 153.249 1.00 95.38  ?  120 ALA R CA  1 
ATOM   82   C C   . ALA A 1 135 ? 108.488 162.146 152.272 1.00 95.38  ?  120 ALA R C   1 
ATOM   83   O O   . ALA A 1 135 ? 108.371 160.928 152.445 1.00 95.38  ?  120 ALA R O   1 
ATOM   84   C CB  . ALA A 1 135 ? 108.501 163.268 154.508 1.00 95.38  ?  120 ALA R CB  1 
ATOM   85   N N   . VAL A 1 136 ? 107.909 162.776 151.250 1.00 94.26  ?  121 VAL R N   1 
ATOM   86   C CA  . VAL A 1 136 ? 107.187 162.057 150.207 1.00 94.26  ?  121 VAL R CA  1 
ATOM   87   C C   . VAL A 1 136 ? 108.123 161.803 149.033 1.00 94.26  ?  121 VAL R C   1 
ATOM   88   O O   . VAL A 1 136 ? 107.985 160.800 148.326 1.00 94.26  ?  121 VAL R O   1 
ATOM   89   C CB  . VAL A 1 136 ? 105.932 162.824 149.755 1.00 94.26  ?  121 VAL R CB  1 
ATOM   90   N N   . LEU A 1 137 ? 109.071 162.716 148.807 1.00 89.22  ?  122 LEU R N   1 
ATOM   91   C CA  . LEU A 1 137 ? 110.018 162.557 147.707 1.00 89.22  ?  122 LEU R CA  1 
ATOM   92   C C   . LEU A 1 137 ? 111.016 161.440 147.984 1.00 89.22  ?  122 LEU R C   1 
ATOM   93   O O   . LEU A 1 137 ? 111.397 160.694 147.077 1.00 89.22  ?  122 LEU R O   1 
ATOM   94   C CB  . LEU A 1 137 ? 110.740 163.884 147.443 1.00 89.22  ?  122 LEU R CB  1 
ATOM   95   C CG  . LEU A 1 137 ? 111.630 164.058 146.207 1.00 89.22  ?  122 LEU R CG  1 
ATOM   96   C CD1 . LEU A 1 137 ? 111.505 165.477 145.708 1.00 89.22  ?  122 LEU R CD1 1 
ATOM   97   C CD2 . LEU A 1 137 ? 113.098 163.766 146.490 1.00 89.22  ?  122 LEU R CD2 1 
ATOM   98   N N   . SER A 1 138 ? 111.470 161.318 149.232 1.00 90.25  ?  123 SER R N   1 
ATOM   99   C CA  . SER A 1 138 ? 112.455 160.292 149.551 1.00 90.25  ?  123 SER R CA  1 
ATOM   100  C C   . SER A 1 138 ? 111.828 158.918 149.730 1.00 90.25  ?  123 SER R C   1 
ATOM   101  O O   . SER A 1 138 ? 112.560 157.936 149.887 1.00 90.25  ?  123 SER R O   1 
ATOM   102  C CB  . SER A 1 138 ? 113.234 160.667 150.807 1.00 90.25  ?  123 SER R CB  1 
ATOM   103  O OG  . SER A 1 138 ? 114.202 159.682 151.102 1.00 90.25  ?  123 SER R OG  1 
ATOM   104  N N   . LEU A 1 139 ? 110.499 158.825 149.734 1.00 90.61  ?  124 LEU R N   1 
ATOM   105  C CA  . LEU A 1 139 ? 109.802 157.548 149.755 1.00 90.61  ?  124 LEU R CA  1 
ATOM   106  C C   . LEU A 1 139 ? 109.453 157.055 148.354 1.00 90.61  ?  124 LEU R C   1 
ATOM   107  O O   . LEU A 1 139 ? 108.891 155.964 148.210 1.00 90.61  ?  124 LEU R O   1 
ATOM   108  C CB  . LEU A 1 139 ? 108.540 157.648 150.611 1.00 90.61  ?  124 LEU R CB  1 
ATOM   109  N N   . THR A 1 140 ? 109.767 157.838 147.321 1.00 87.67  ?  125 THR R N   1 
ATOM   110  C CA  . THR A 1 140 ? 109.567 157.416 145.939 1.00 87.67  ?  125 THR R CA  1 
ATOM   111  C C   . THR A 1 140 ? 110.874 157.417 145.157 1.00 87.67  ?  125 THR R C   1 
ATOM   112  O O   . THR A 1 140 ? 110.972 156.727 144.141 1.00 87.67  ?  125 THR R O   1 
ATOM   113  C CB  . THR A 1 140 ? 108.498 158.279 145.245 1.00 87.67  ?  125 THR R CB  1 
ATOM   114  O OG1 . THR A 1 140 ? 108.223 157.747 143.944 1.00 87.67  ?  125 THR R OG1 1 
ATOM   115  C CG2 . THR A 1 140 ? 108.937 159.723 145.109 1.00 87.67  ?  125 THR R CG2 1 
ATOM   116  N N   . LEU A 1 141 ? 111.876 158.189 145.576 1.00 84.21  ?  126 LEU R N   1 
ATOM   117  C CA  . LEU A 1 141 ? 113.213 158.039 145.017 1.00 84.21  ?  126 LEU R CA  1 
ATOM   118  C C   . LEU A 1 141 ? 114.113 157.276 145.977 1.00 84.21  ?  126 LEU R C   1 
ATOM   119  O O   . LEU A 1 141 ? 115.337 157.291 145.828 1.00 84.21  ?  126 LEU R O   1 
ATOM   120  C CB  . LEU A 1 141 ? 113.836 159.394 144.677 1.00 84.21  ?  126 LEU R CB  1 
ATOM   121  C CG  . LEU A 1 141 ? 113.551 160.002 143.301 1.00 84.21  ?  126 LEU R CG  1 
ATOM   122  C CD1 . LEU A 1 141 ? 112.130 160.522 143.175 1.00 84.21  ?  126 LEU R CD1 1 
ATOM   123  C CD2 . LEU A 1 141 ? 114.553 161.105 143.014 1.00 84.21  ?  126 LEU R CD2 1 
ATOM   124  N N   . GLY A 1 142 ? 113.522 156.612 146.966 1.00 82.20  ?  127 GLY R N   1 
ATOM   125  C CA  . GLY A 1 142 ? 114.307 155.878 147.938 1.00 82.20  ?  127 GLY R CA  1 
ATOM   126  C C   . GLY A 1 142 ? 113.969 154.406 148.047 1.00 82.20  ?  127 GLY R C   1 
ATOM   127  O O   . GLY A 1 142 ? 114.797 153.608 148.492 1.00 82.20  ?  127 GLY R O   1 
ATOM   128  N N   . THR A 1 143 ? 112.754 154.032 147.661 1.00 83.78  ?  128 THR R N   1 
ATOM   129  C CA  . THR A 1 143 ? 112.336 152.638 147.709 1.00 83.78  ?  128 THR R CA  1 
ATOM   130  C C   . THR A 1 143 ? 112.538 151.909 146.388 1.00 83.78  ?  128 THR R C   1 
ATOM   131  O O   . THR A 1 143 ? 112.510 150.675 146.371 1.00 83.78  ?  128 THR R O   1 
ATOM   132  C CB  . THR A 1 143 ? 110.868 152.531 148.130 1.00 83.78  ?  128 THR R CB  1 
ATOM   133  O OG1 . THR A 1 143 ? 110.042 153.207 147.174 1.00 83.78  ?  128 THR R OG1 1 
ATOM   134  C CG2 . THR A 1 143 ? 110.665 153.150 149.498 1.00 83.78  ?  128 THR R CG2 1 
ATOM   135  N N   . PHE A 1 144 ? 112.735 152.630 145.284 1.00 83.89  ?  129 PHE R N   1 
ATOM   136  C CA  . PHE A 1 144 ? 113.056 151.961 144.029 1.00 83.89  ?  129 PHE R CA  1 
ATOM   137  C C   . PHE A 1 144 ? 114.538 151.620 143.947 1.00 83.89  ?  129 PHE R C   1 
ATOM   138  O O   . PHE A 1 144 ? 114.904 150.535 143.490 1.00 83.89  ?  129 PHE R O   1 
ATOM   139  C CB  . PHE A 1 144 ? 112.629 152.815 142.837 1.00 83.89  ?  129 PHE R CB  1 
ATOM   140  C CG  . PHE A 1 144 ? 111.156 152.798 142.585 1.00 83.89  ?  129 PHE R CG  1 
ATOM   141  C CD1 . PHE A 1 144 ? 110.569 151.727 141.930 1.00 83.89  ?  129 PHE R CD1 1 
ATOM   142  C CD2 . PHE A 1 144 ? 110.355 153.844 143.001 1.00 83.89  ?  129 PHE R CD2 1 
ATOM   143  C CE1 . PHE A 1 144 ? 109.207 151.701 141.694 1.00 83.89  ?  129 PHE R CE1 1 
ATOM   144  C CE2 . PHE A 1 144 ? 108.993 153.829 142.768 1.00 83.89  ?  129 PHE R CE2 1 
ATOM   145  C CZ  . PHE A 1 144 ? 108.418 152.755 142.114 1.00 83.89  ?  129 PHE R CZ  1 
ATOM   146  N N   . THR A 1 145 ? 115.403 152.533 144.392 1.00 80.88  ?  130 THR R N   1 
ATOM   147  C CA  . THR A 1 145 ? 116.845 152.305 144.416 1.00 80.88  ?  130 THR R CA  1 
ATOM   148  C C   . THR A 1 145 ? 117.246 151.136 145.315 1.00 80.88  ?  130 THR R C   1 
ATOM   149  O O   . THR A 1 145 ? 118.286 150.510 145.092 1.00 80.88  ?  130 THR R O   1 
ATOM   150  C CB  . THR A 1 145 ? 117.582 153.585 144.824 1.00 80.88  ?  130 THR R CB  1 
ATOM   151  O OG1 . THR A 1 145 ? 118.993 153.340 144.851 1.00 80.88  ?  130 THR R OG1 1 
ATOM   152  C CG2 . THR A 1 145 ? 117.119 154.099 146.173 1.00 80.88  ?  130 THR R CG2 1 
ATOM   153  N N   . VAL A 1 146 ? 116.439 150.842 146.335 1.00 79.29  ?  131 VAL R N   1 
ATOM   154  C CA  . VAL A 1 146 ? 116.609 149.613 147.101 1.00 79.29  ?  131 VAL R CA  1 
ATOM   155  C C   . VAL A 1 146 ? 116.098 148.415 146.311 1.00 79.29  ?  131 VAL R C   1 
ATOM   156  O O   . VAL A 1 146 ? 116.749 147.366 146.251 1.00 79.29  ?  131 VAL R O   1 
ATOM   157  C CB  . VAL A 1 146 ? 115.901 149.743 148.463 1.00 79.29  ?  131 VAL R CB  1 
ATOM   158  C CG1 . VAL A 1 146 ? 115.918 148.425 149.228 1.00 79.29  ?  131 VAL R CG1 1 
ATOM   159  C CG2 . VAL A 1 146 ? 116.550 150.838 149.285 1.00 79.29  ?  131 VAL R CG2 1 
ATOM   160  N N   . LEU A 1 147 ? 114.944 148.561 145.662 1.00 77.66  ?  132 LEU R N   1 
ATOM   161  C CA  . LEU A 1 147 ? 114.309 147.440 144.981 1.00 77.66  ?  132 LEU R CA  1 
ATOM   162  C C   . LEU A 1 147 ? 114.796 147.252 143.547 1.00 77.66  ?  132 LEU R C   1 
ATOM   163  O O   . LEU A 1 147 ? 114.248 146.421 142.818 1.00 77.66  ?  132 LEU R O   1 
ATOM   164  C CB  . LEU A 1 147 ? 112.789 147.612 144.993 1.00 77.66  ?  132 LEU R CB  1 
ATOM   165  N N   . GLU A 1 148 ? 115.809 148.007 143.120 1.00 75.99  ?  133 GLU R N   1 
ATOM   166  C CA  . GLU A 1 148 ? 116.394 147.770 141.803 1.00 75.99  ?  133 GLU R CA  1 
ATOM   167  C C   . GLU A 1 148 ? 117.820 147.261 141.923 1.00 75.99  ?  133 GLU R C   1 
ATOM   168  O O   . GLU A 1 148 ? 118.206 146.341 141.200 1.00 75.99  ?  133 GLU R O   1 
ATOM   169  C CB  . GLU A 1 148 ? 116.353 149.026 140.930 1.00 75.99  ?  133 GLU R CB  1 
ATOM   170  C CG  . GLU A 1 148 ? 114.962 149.389 140.437 1.00 75.99  ?  133 GLU R CG  1 
ATOM   171  C CD  . GLU A 1 148 ? 114.396 148.369 139.472 1.00 75.99  ?  133 GLU R CD  1 
ATOM   172  O OE1 . GLU A 1 148 ? 115.175 147.797 138.684 1.00 75.99  ?  133 GLU R OE1 1 
ATOM   173  O OE2 . GLU A 1 148 ? 113.171 148.127 139.508 1.00 75.99  -1 133 GLU R OE2 1 
ATOM   174  N N   . ASN A 1 149 ? 118.608 147.820 142.842 1.00 72.36  ?  134 ASN R N   1 
ATOM   175  C CA  . ASN A 1 149 ? 119.978 147.360 143.055 1.00 72.36  ?  134 ASN R CA  1 
ATOM   176  C C   . ASN A 1 149 ? 120.034 145.991 143.726 1.00 72.36  ?  134 ASN R C   1 
ATOM   177  O O   . ASN A 1 149 ? 121.104 145.382 143.818 1.00 72.36  ?  134 ASN R O   1 
ATOM   178  C CB  . ASN A 1 149 ? 120.762 148.370 143.893 1.00 72.36  ?  134 ASN R CB  1 
ATOM   179  C CG  . ASN A 1 149 ? 121.072 149.639 143.136 1.00 72.36  ?  134 ASN R CG  1 
ATOM   180  O OD1 . ASN A 1 149 ? 121.434 149.602 141.963 1.00 72.36  ?  134 ASN R OD1 1 
ATOM   181  N ND2 . ASN A 1 149 ? 120.938 150.773 143.807 1.00 72.36  ?  134 ASN R ND2 1 
ATOM   182  N N   . LEU A 1 150 ? 118.895 145.507 144.214 1.00 71.80  ?  135 LEU R N   1 
ATOM   183  C CA  . LEU A 1 150 ? 118.816 144.183 144.835 1.00 71.80  ?  135 LEU R CA  1 
ATOM   184  C C   . LEU A 1 150 ? 118.524 143.133 143.765 1.00 71.80  ?  135 LEU R C   1 
ATOM   185  O O   . LEU A 1 150 ? 119.142 142.065 143.748 1.00 71.80  ?  135 LEU R O   1 
ATOM   186  C CB  . LEU A 1 150 ? 117.763 144.199 145.944 1.00 71.80  ?  135 LEU R CB  1 
ATOM   187  C CG  . LEU A 1 150 ? 117.679 143.011 146.892 1.00 71.80  ?  135 LEU R CG  1 
ATOM   188  C CD1 . LEU A 1 150 ? 118.988 142.867 147.629 1.00 71.80  ?  135 LEU R CD1 1 
ATOM   189  C CD2 . LEU A 1 150 ? 116.548 143.212 147.875 1.00 71.80  ?  135 LEU R CD2 1 
ATOM   190  N N   . LEU A 1 151 ? 117.584 143.429 142.863 1.00 68.55  ?  136 LEU R N   1 
ATOM   191  C CA  . LEU A 1 151 ? 117.210 142.520 141.781 1.00 68.55  ?  136 LEU R CA  1 
ATOM   192  C C   . LEU A 1 151 ? 118.325 142.357 140.749 1.00 68.55  ?  136 LEU R C   1 
ATOM   193  O O   . LEU A 1 151 ? 118.416 141.313 140.097 1.00 68.55  ?  136 LEU R O   1 
ATOM   194  C CB  . LEU A 1 151 ? 115.918 143.003 141.112 1.00 68.55  ?  136 LEU R CB  1 
ATOM   195  C CG  . LEU A 1 151 ? 115.175 142.098 140.120 1.00 68.55  ?  136 LEU R CG  1 
ATOM   196  C CD1 . LEU A 1 151 ? 113.683 142.298 140.280 1.00 68.55  ?  136 LEU R CD1 1 
ATOM   197  C CD2 . LEU A 1 151 ? 115.559 142.365 138.667 1.00 68.55  ?  136 LEU R CD2 1 
ATOM   198  N N   . VAL A 1 152 ? 119.158 143.384 140.573 1.00 68.85  ?  137 VAL R N   1 
ATOM   199  C CA  . VAL A 1 152 ? 120.321 143.317 139.690 1.00 68.85  ?  137 VAL R CA  1 
ATOM   200  C C   . VAL A 1 152 ? 121.321 142.323 140.264 1.00 68.85  ?  137 VAL R C   1 
ATOM   201  O O   . VAL A 1 152 ? 121.971 141.576 139.524 1.00 68.85  ?  137 VAL R O   1 
ATOM   202  C CB  . VAL A 1 152 ? 120.932 144.720 139.493 1.00 68.85  ?  137 VAL R CB  1 
ATOM   203  C CG1 . VAL A 1 152 ? 122.315 144.672 138.867 1.00 68.85  ?  137 VAL R CG1 1 
ATOM   204  C CG2 . VAL A 1 152 ? 120.032 145.528 138.592 1.00 68.85  ?  137 VAL R CG2 1 
ATOM   205  N N   . LEU A 1 153 ? 121.378 142.225 141.591 1.00 67.01  ?  138 LEU R N   1 
ATOM   206  C CA  . LEU A 1 153 ? 122.254 141.237 142.205 1.00 67.01  ?  138 LEU R CA  1 
ATOM   207  C C   . LEU A 1 153 ? 121.524 139.901 142.370 1.00 67.01  ?  138 LEU R C   1 
ATOM   208  O O   . LEU A 1 153 ? 122.024 139.006 143.057 1.00 67.01  ?  138 LEU R O   1 
ATOM   209  C CB  . LEU A 1 153 ? 122.785 141.786 143.540 1.00 67.01  ?  138 LEU R CB  1 
ATOM   210  C CG  . LEU A 1 153 ? 124.049 141.239 144.215 1.00 67.01  ?  138 LEU R CG  1 
ATOM   211  C CD1 . LEU A 1 153 ? 125.266 141.515 143.357 1.00 67.01  ?  138 LEU R CD1 1 
ATOM   212  C CD2 . LEU A 1 153 ? 124.227 141.851 145.588 1.00 67.01  ?  138 LEU R CD2 1 
ATOM   213  N N   . CYS A 1 154 ? 120.365 139.733 141.728 1.00 64.16  ?  139 CYS R N   1 
ATOM   214  C CA  . CYS A 1 154 ? 119.616 138.483 141.730 1.00 64.16  ?  139 CYS R CA  1 
ATOM   215  C C   . CYS A 1 154 ? 119.674 137.839 140.347 1.00 64.16  ?  139 CYS R C   1 
ATOM   216  O O   . CYS A 1 154 ? 119.053 136.804 140.102 1.00 64.16  ?  139 CYS R O   1 
ATOM   217  C CB  . CYS A 1 154 ? 118.171 138.729 142.175 1.00 64.16  ?  139 CYS R CB  1 
ATOM   218  S SG  . CYS A 1 154 ? 117.118 137.289 142.543 1.00 64.16  ?  139 CYS R SG  1 
ATOM   219  N N   . VAL A 1 155 ? 120.427 138.441 139.428 1.00 65.97  ?  140 VAL R N   1 
ATOM   220  C CA  . VAL A 1 155 ? 120.688 137.854 138.116 1.00 65.97  ?  140 VAL R CA  1 
ATOM   221  C C   . VAL A 1 155 ? 122.189 137.843 137.859 1.00 65.97  ?  140 VAL R C   1 
ATOM   222  O O   . VAL A 1 155 ? 122.640 138.002 136.720 1.00 65.97  ?  140 VAL R O   1 
ATOM   223  C CB  . VAL A 1 155 ? 119.928 138.585 136.997 1.00 65.97  ?  140 VAL R CB  1 
ATOM   224  C CG1 . VAL A 1 155 ? 118.449 138.280 137.083 1.00 65.97  ?  140 VAL R CG1 1 
ATOM   225  C CG2 . VAL A 1 155 ? 120.141 140.077 137.101 1.00 65.97  ?  140 VAL R CG2 1 
ATOM   226  N N   . ILE A 1 156 ? 122.969 137.664 138.918 1.00 66.23  ?  141 ILE R N   1 
ATOM   227  C CA  . ILE A 1 156 ? 124.409 137.499 138.803 1.00 66.23  ?  141 ILE R CA  1 
ATOM   228  C C   . ILE A 1 156 ? 124.902 136.533 139.869 1.00 66.23  ?  141 ILE R C   1 
ATOM   229  O O   . ILE A 1 156 ? 124.162 135.657 140.316 1.00 66.23  ?  141 ILE R O   1 
ATOM   230  C CB  . ILE A 1 156 ? 125.131 138.840 138.909 1.00 66.23  ?  141 ILE R CB  1 
ATOM   231  C CG1 . ILE A 1 156 ? 126.606 138.680 138.571 1.00 66.23  ?  141 ILE R CG1 1 
ATOM   232  C CG2 . ILE A 1 156 ? 125.015 139.383 140.301 1.00 66.23  ?  141 ILE R CG2 1 
ATOM   233  C CD1 . ILE A 1 156 ? 127.303 139.990 138.364 1.00 66.23  ?  141 ILE R CD1 1 
ATOM   234  N N   . ARG A 1 163 ? 126.679 135.127 133.684 1.00 70.50  ?  148 ARG R N   1 
ATOM   235  C CA  . ARG A 1 163 ? 126.822 135.553 135.069 1.00 70.50  ?  148 ARG R CA  1 
ATOM   236  C C   . ARG A 1 163 ? 128.212 136.135 135.342 1.00 70.50  ?  148 ARG R C   1 
ATOM   237  O O   . ARG A 1 163 ? 128.634 137.071 134.666 1.00 70.50  ?  148 ARG R O   1 
ATOM   238  C CB  . ARG A 1 163 ? 126.530 134.391 136.026 1.00 70.50  ?  148 ARG R CB  1 
ATOM   239  C CG  . ARG A 1 163 ? 125.058 133.995 136.133 1.00 70.50  ?  148 ARG R CG  1 
ATOM   240  C CD  . ARG A 1 163 ? 124.881 132.885 137.158 1.00 70.50  ?  148 ARG R CD  1 
ATOM   241  N NE  . ARG A 1 163 ? 123.503 132.416 137.303 1.00 70.50  ?  148 ARG R NE  1 
ATOM   242  C CZ  . ARG A 1 163 ? 122.642 132.862 138.214 1.00 70.50  ?  148 ARG R CZ  1 
ATOM   243  N NH1 . ARG A 1 163 ? 121.418 132.361 138.264 1.00 70.50  ?  148 ARG R NH1 1 
ATOM   244  N NH2 . ARG A 1 163 ? 123.000 133.795 139.083 1.00 70.50  ?  148 ARG R NH2 1 
ATOM   245  N N   . CYS A 1 164 ? 128.920 135.578 136.325 1.00 69.50  ?  149 CYS R N   1 
ATOM   246  C CA  . CYS A 1 164 ? 130.134 136.194 136.863 1.00 69.50  ?  149 CYS R CA  1 
ATOM   247  C C   . CYS A 1 164 ? 131.340 135.897 135.973 1.00 69.50  ?  149 CYS R C   1 
ATOM   248  O O   . CYS A 1 164 ? 131.802 134.760 135.871 1.00 69.50  ?  149 CYS R O   1 
ATOM   249  C CB  . CYS A 1 164 ? 130.354 135.751 138.306 1.00 69.50  ?  149 CYS R CB  1 
ATOM   250  S SG  . CYS A 1 164 ? 130.370 133.975 138.620 1.00 69.50  ?  149 CYS R SG  1 
ATOM   251  N N   . ARG A 1 165 ? 131.841 136.945 135.321 1.00 68.30  ?  150 ARG R N   1 
ATOM   252  C CA  . ARG A 1 165 ? 133.053 137.009 134.519 1.00 68.30  ?  150 ARG R CA  1 
ATOM   253  C C   . ARG A 1 165 ? 133.834 138.232 134.986 1.00 68.30  ?  150 ARG R C   1 
ATOM   254  O O   . ARG A 1 165 ? 133.217 139.158 135.525 1.00 68.30  ?  150 ARG R O   1 
ATOM   255  C CB  . ARG A 1 165 ? 132.702 137.096 133.020 1.00 68.30  ?  150 ARG R CB  1 
ATOM   256  C CG  . ARG A 1 165 ? 132.171 135.793 132.453 1.00 68.30  ?  150 ARG R CG  1 
ATOM   257  C CD  . ARG A 1 165 ? 132.056 135.848 130.946 1.00 68.30  ?  150 ARG R CD  1 
ATOM   258  N NE  . ARG A 1 165 ? 130.993 136.740 130.505 1.00 68.30  ?  150 ARG R NE  1 
ATOM   259  C CZ  . ARG A 1 165 ? 131.203 137.883 129.868 1.00 68.30  ?  150 ARG R CZ  1 
ATOM   260  N NH1 . ARG A 1 165 ? 130.178 138.635 129.495 1.00 68.30  ?  150 ARG R NH1 1 
ATOM   261  N NH2 . ARG A 1 165 ? 132.440 138.273 129.607 1.00 68.30  ?  150 ARG R NH2 1 
ATOM   262  N N   . PRO A 1 166 ? 135.195 138.291 134.807 1.00 64.06  ?  151 PRO R N   1 
ATOM   263  C CA  . PRO A 1 166 ? 135.990 139.309 135.526 1.00 64.06  ?  151 PRO R CA  1 
ATOM   264  C C   . PRO A 1 166 ? 135.755 140.777 135.179 1.00 64.06  ?  151 PRO R C   1 
ATOM   265  O O   . PRO A 1 166 ? 136.494 141.637 135.662 1.00 64.06  ?  151 PRO R O   1 
ATOM   266  C CB  . PRO A 1 166 ? 137.434 138.916 135.197 1.00 64.06  ?  151 PRO R CB  1 
ATOM   267  C CG  . PRO A 1 166 ? 137.349 138.158 133.951 1.00 64.06  ?  151 PRO R CG  1 
ATOM   268  C CD  . PRO A 1 166 ? 136.075 137.391 134.039 1.00 64.06  ?  151 PRO R CD  1 
ATOM   269  N N   . SER A 1 167 ? 134.759 141.087 134.340 1.00 62.47  ?  152 SER R N   1 
ATOM   270  C CA  . SER A 1 167 ? 134.275 142.461 134.263 1.00 62.47  ?  152 SER R CA  1 
ATOM   271  C C   . SER A 1 167 ? 132.858 142.605 134.811 1.00 62.47  ?  152 SER R C   1 
ATOM   272  O O   . SER A 1 167 ? 132.260 143.674 134.654 1.00 62.47  ?  152 SER R O   1 
ATOM   273  C CB  . SER A 1 167 ? 134.308 142.982 132.827 1.00 62.47  ?  152 SER R CB  1 
ATOM   274  O OG  . SER A 1 167 ? 133.798 144.302 132.769 1.00 62.47  ?  152 SER R OG  1 
ATOM   275  N N   . TYR A 1 168 ? 132.303 141.570 135.443 1.00 65.97  ?  153 TYR R N   1 
ATOM   276  C CA  . TYR A 1 168 ? 131.033 141.677 136.148 1.00 65.97  ?  153 TYR R CA  1 
ATOM   277  C C   . TYR A 1 168 ? 131.215 141.670 137.657 1.00 65.97  ?  153 TYR R C   1 
ATOM   278  O O   . TYR A 1 168 ? 130.226 141.585 138.391 1.00 65.97  ?  153 TYR R O   1 
ATOM   279  C CB  . TYR A 1 168 ? 130.076 140.558 135.734 1.00 65.97  ?  153 TYR R CB  1 
ATOM   280  C CG  . TYR A 1 168 ? 129.503 140.728 134.349 1.00 65.97  ?  153 TYR R CG  1 
ATOM   281  C CD1 . TYR A 1 168 ? 128.430 141.577 134.126 1.00 65.97  ?  153 TYR R CD1 1 
ATOM   282  C CD2 . TYR A 1 168 ? 130.033 140.043 133.268 1.00 65.97  ?  153 TYR R CD2 1 
ATOM   283  C CE1 . TYR A 1 168 ? 127.904 141.741 132.865 1.00 65.97  ?  153 TYR R CE1 1 
ATOM   284  C CE2 . TYR A 1 168 ? 129.511 140.202 132.001 1.00 65.97  ?  153 TYR R CE2 1 
ATOM   285  C CZ  . TYR A 1 168 ? 128.448 141.053 131.811 1.00 65.97  ?  153 TYR R CZ  1 
ATOM   286  O OH  . TYR A 1 168 ? 127.918 141.219 130.553 1.00 65.97  ?  153 TYR R OH  1 
ATOM   287  N N   . HIS A 1 169 ? 132.453 141.740 138.137 1.00 64.26  ?  154 HIS R N   1 
ATOM   288  C CA  . HIS A 1 169 ? 132.730 142.012 139.542 1.00 64.26  ?  154 HIS R CA  1 
ATOM   289  C C   . HIS A 1 169 ? 132.666 143.510 139.817 1.00 64.26  ?  154 HIS R C   1 
ATOM   290  O O   . HIS A 1 169 ? 132.177 143.940 140.866 1.00 64.26  ?  154 HIS R O   1 
ATOM   291  C CB  . HIS A 1 169 ? 134.105 141.458 139.922 1.00 64.26  ?  154 HIS R CB  1 
ATOM   292  C CG  . HIS A 1 169 ? 134.173 139.965 139.935 1.00 64.26  ?  154 HIS R CG  1 
ATOM   293  N ND1 . HIS A 1 169 ? 135.362 139.277 140.026 1.00 64.26  ?  154 HIS R ND1 1 
ATOM   294  C CD2 . HIS A 1 169 ? 133.199 139.027 139.884 1.00 64.26  ?  154 HIS R CD2 1 
ATOM   295  C CE1 . HIS A 1 169 ? 135.119 137.979 140.023 1.00 64.26  ?  154 HIS R CE1 1 
ATOM   296  N NE2 . HIS A 1 169 ? 133.814 137.801 139.939 1.00 64.26  ?  154 HIS R NE2 1 
ATOM   297  N N   . PHE A 1 170 ? 133.161 144.311 138.874 1.00 61.41  ?  155 PHE R N   1 
ATOM   298  C CA  . PHE A 1 170 ? 133.215 145.757 139.039 1.00 61.41  ?  155 PHE R CA  1 
ATOM   299  C C   . PHE A 1 170 ? 131.840 146.402 138.959 1.00 61.41  ?  155 PHE R C   1 
ATOM   300  O O   . PHE A 1 170 ? 131.629 147.459 139.560 1.00 61.41  ?  155 PHE R O   1 
ATOM   301  C CB  . PHE A 1 170 ? 134.136 146.349 137.977 1.00 61.41  ?  155 PHE R CB  1 
ATOM   302  C CG  . PHE A 1 170 ? 135.585 146.007 138.162 1.00 61.41  ?  155 PHE R CG  1 
ATOM   303  C CD1 . PHE A 1 170 ? 136.077 145.624 139.396 1.00 61.41  ?  155 PHE R CD1 1 
ATOM   304  C CD2 . PHE A 1 170 ? 136.453 146.050 137.086 1.00 61.41  ?  155 PHE R CD2 1 
ATOM   305  C CE1 . PHE A 1 170 ? 137.405 145.310 139.554 1.00 61.41  ?  155 PHE R CE1 1 
ATOM   306  C CE2 . PHE A 1 170 ? 137.784 145.736 137.240 1.00 61.41  ?  155 PHE R CE2 1 
ATOM   307  C CZ  . PHE A 1 170 ? 138.259 145.366 138.474 1.00 61.41  ?  155 PHE R CZ  1 
ATOM   308  N N   . ILE A 1 171 ? 130.904 145.798 138.227 1.00 65.07  ?  156 ILE R N   1 
ATOM   309  C CA  . ILE A 1 171 ? 129.520 146.250 138.193 1.00 65.07  ?  156 ILE R CA  1 
ATOM   310  C C   . ILE A 1 171 ? 128.746 145.727 139.403 1.00 65.07  ?  156 ILE R C   1 
ATOM   311  O O   . ILE A 1 171 ? 127.714 146.290 139.782 1.00 65.07  ?  156 ILE R O   1 
ATOM   312  C CB  . ILE A 1 171 ? 128.870 145.834 136.858 1.00 65.07  ?  156 ILE R CB  1 
ATOM   313  C CG1 . ILE A 1 171 ? 129.722 146.347 135.702 1.00 65.07  ?  156 ILE R CG1 1 
ATOM   314  C CG2 . ILE A 1 171 ? 127.498 146.446 136.640 1.00 65.07  ?  156 ILE R CG2 1 
ATOM   315  C CD1 . ILE A 1 171 ? 129.333 145.788 134.356 1.00 65.07  ?  156 ILE R CD1 1 
ATOM   316  N N   . GLY A 1 172 ? 129.284 144.724 140.085 1.00 64.21  ?  157 GLY R N   1 
ATOM   317  C CA  . GLY A 1 172 ? 128.642 144.203 141.270 1.00 64.21  ?  157 GLY R CA  1 
ATOM   318  C C   . GLY A 1 172 ? 128.965 145.011 142.508 1.00 64.21  ?  157 GLY R C   1 
ATOM   319  O O   . GLY A 1 172 ? 128.123 145.133 143.401 1.00 64.21  ?  157 GLY R O   1 
ATOM   320  N N   . SER A 1 173 ? 130.169 145.583 142.574 1.00 61.70  ?  158 SER R N   1 
ATOM   321  C CA  . SER A 1 173 ? 130.592 146.311 143.765 1.00 61.70  ?  158 SER R CA  1 
ATOM   322  C C   . SER A 1 173 ? 130.129 147.762 143.753 1.00 61.70  ?  158 SER R C   1 
ATOM   323  O O   . SER A 1 173 ? 130.510 148.537 144.633 1.00 61.70  ?  158 SER R O   1 
ATOM   324  C CB  . SER A 1 173 ? 132.110 146.270 143.920 1.00 61.70  ?  158 SER R CB  1 
ATOM   325  O OG  . SER A 1 173 ? 132.736 147.086 142.951 1.00 61.70  ?  158 SER R OG  1 
ATOM   326  N N   . LEU A 1 174 ? 129.333 148.154 142.755 1.00 61.94  ?  159 LEU R N   1 
ATOM   327  C CA  . LEU A 1 174 ? 128.629 149.427 142.829 1.00 61.94  ?  159 LEU R CA  1 
ATOM   328  C C   . LEU A 1 174 ? 127.124 149.214 142.823 1.00 61.94  ?  159 LEU R C   1 
ATOM   329  O O   . LEU A 1 174 ? 126.375 150.196 142.771 1.00 61.94  ?  159 LEU R O   1 
ATOM   330  C CB  . LEU A 1 174 ? 129.047 150.382 141.696 1.00 61.94  ?  159 LEU R CB  1 
ATOM   331  C CG  . LEU A 1 174 ? 128.820 150.133 140.203 1.00 61.94  ?  159 LEU R CG  1 
ATOM   332  C CD1 . LEU A 1 174 ? 127.511 150.725 139.695 1.00 61.94  ?  159 LEU R CD1 1 
ATOM   333  C CD2 . LEU A 1 174 ? 129.986 150.685 139.410 1.00 61.94  ?  159 LEU R CD2 1 
ATOM   334  N N   . ALA A 1 175 ? 126.665 147.968 142.870 1.00 65.20  ?  160 ALA R N   1 
ATOM   335  C CA  . ALA A 1 175 ? 125.278 147.662 143.168 1.00 65.20  ?  160 ALA R CA  1 
ATOM   336  C C   . ALA A 1 175 ? 125.109 147.192 144.602 1.00 65.20  ?  160 ALA R C   1 
ATOM   337  O O   . ALA A 1 175 ? 123.971 147.050 145.065 1.00 65.20  ?  160 ALA R O   1 
ATOM   338  C CB  . ALA A 1 175 ? 124.739 146.601 142.203 1.00 65.20  ?  160 ALA R CB  1 
ATOM   339  N N   . VAL A 1 176 ? 126.206 146.941 145.311 1.00 64.06  ?  161 VAL R N   1 
ATOM   340  C CA  . VAL A 1 176 ? 126.182 146.711 146.747 1.00 64.06  ?  161 VAL R CA  1 
ATOM   341  C C   . VAL A 1 176 ? 126.617 147.958 147.510 1.00 64.06  ?  161 VAL R C   1 
ATOM   342  O O   . VAL A 1 176 ? 126.260 148.136 148.673 1.00 64.06  ?  161 VAL R O   1 
ATOM   343  C CB  . VAL A 1 176 ? 127.053 145.481 147.103 1.00 64.06  ?  161 VAL R CB  1 
ATOM   344  C CG1 . VAL A 1 176 ? 128.535 145.768 146.937 1.00 64.06  ?  161 VAL R CG1 1 
ATOM   345  C CG2 . VAL A 1 176 ? 126.748 144.946 148.494 1.00 64.06  ?  161 VAL R CG2 1 
ATOM   346  N N   . ALA A 1 177 ? 127.344 148.862 146.852 1.00 64.83  ?  162 ALA R N   1 
ATOM   347  C CA  . ALA A 1 177 ? 127.722 150.136 147.444 1.00 64.83  ?  162 ALA R CA  1 
ATOM   348  C C   . ALA A 1 177 ? 126.705 151.230 147.178 1.00 64.83  ?  162 ALA R C   1 
ATOM   349  O O   . ALA A 1 177 ? 126.947 152.388 147.529 1.00 64.83  ?  162 ALA R O   1 
ATOM   350  C CB  . ALA A 1 177 ? 129.094 150.571 146.935 1.00 64.83  ?  162 ALA R CB  1 
ATOM   351  N N   . ASP A 1 178 ? 125.580 150.892 146.553 1.00 71.32  ?  163 ASP R N   1 
ATOM   352  C CA  . ASP A 1 178 ? 124.476 151.830 146.411 1.00 71.32  ?  163 ASP R CA  1 
ATOM   353  C C   . ASP A 1 178 ? 123.206 151.280 147.043 1.00 71.32  ?  163 ASP R C   1 
ATOM   354  O O   . ASP A 1 178 ? 122.131 151.857 146.846 1.00 71.32  ?  163 ASP R O   1 
ATOM   355  C CB  . ASP A 1 178 ? 124.227 152.170 144.940 1.00 71.32  ?  163 ASP R CB  1 
ATOM   356  N N   . LEU A 1 179 ? 123.297 150.169 147.767 1.00 69.44  ?  164 LEU R N   1 
ATOM   357  C CA  . LEU A 1 179 ? 122.229 149.682 148.622 1.00 69.44  ?  164 LEU R CA  1 
ATOM   358  C C   . LEU A 1 179 ? 122.494 149.992 150.088 1.00 69.44  ?  164 LEU R C   1 
ATOM   359  O O   . LEU A 1 179 ? 121.543 150.090 150.868 1.00 69.44  ?  164 LEU R O   1 
ATOM   360  C CB  . LEU A 1 179 ? 122.048 148.170 148.407 1.00 69.44  ?  164 LEU R CB  1 
ATOM   361  C CG  . LEU A 1 179 ? 120.881 147.347 148.967 1.00 69.44  ?  164 LEU R CG  1 
ATOM   362  C CD1 . LEU A 1 179 ? 121.101 146.834 150.387 1.00 69.44  ?  164 LEU R CD1 1 
ATOM   363  C CD2 . LEU A 1 179 ? 119.619 148.173 148.905 1.00 69.44  ?  164 LEU R CD2 1 
ATOM   364  N N   . LEU A 1 180 ? 123.759 150.162 150.471 1.00 71.20  ?  165 LEU R N   1 
ATOM   365  C CA  . LEU A 1 180 ? 124.147 150.606 151.804 1.00 71.20  ?  165 LEU R CA  1 
ATOM   366  C C   . LEU A 1 180 ? 124.160 152.123 151.921 1.00 71.20  ?  165 LEU R C   1 
ATOM   367  O O   . LEU A 1 180 ? 123.821 152.666 152.974 1.00 71.20  ?  165 LEU R O   1 
ATOM   368  C CB  . LEU A 1 180 ? 125.526 150.049 152.179 1.00 71.20  ?  165 LEU R CB  1 
ATOM   369  C CG  . LEU A 1 180 ? 125.638 148.656 152.805 1.00 71.20  ?  165 LEU R CG  1 
ATOM   370  C CD1 . LEU A 1 180 ? 125.355 147.540 151.817 1.00 71.20  ?  165 LEU R CD1 1 
ATOM   371  C CD2 . LEU A 1 180 ? 127.015 148.477 153.421 1.00 71.20  ?  165 LEU R CD2 1 
ATOM   372  N N   . GLY A 1 181 ? 124.529 152.820 150.852 1.00 68.80  ?  166 GLY R N   1 
ATOM   373  C CA  . GLY A 1 181 ? 124.560 154.268 150.868 1.00 68.80  ?  166 GLY R CA  1 
ATOM   374  C C   . GLY A 1 181 ? 123.196 154.907 150.728 1.00 68.80  ?  166 GLY R C   1 
ATOM   375  O O   . GLY A 1 181 ? 123.065 156.127 150.833 1.00 68.80  ?  166 GLY R O   1 
ATOM   376  N N   . SER A 1 182 ? 122.170 154.092 150.488 1.00 70.54  ?  167 SER R N   1 
ATOM   377  C CA  . SER A 1 182 ? 120.794 154.562 150.407 1.00 70.54  ?  167 SER R CA  1 
ATOM   378  C C   . SER A 1 182 ? 119.951 154.084 151.579 1.00 70.54  ?  167 SER R C   1 
ATOM   379  O O   . SER A 1 182 ? 118.719 154.139 151.508 1.00 70.54  ?  167 SER R O   1 
ATOM   380  C CB  . SER A 1 182 ? 120.150 154.119 149.094 1.00 70.54  ?  167 SER R CB  1 
ATOM   381  O OG  . SER A 1 182 ? 118.795 154.521 149.047 1.00 70.54  ?  167 SER R OG  1 
ATOM   382  N N   . VAL A 1 183 ? 120.578 153.580 152.637 1.00 73.57  ?  168 VAL R N   1 
ATOM   383  C CA  . VAL A 1 183 ? 119.886 153.313 153.890 1.00 73.57  ?  168 VAL R CA  1 
ATOM   384  C C   . VAL A 1 183 ? 120.405 154.175 155.031 1.00 73.57  ?  168 VAL R C   1 
ATOM   385  O O   . VAL A 1 183 ? 119.591 154.731 155.787 1.00 73.57  ?  168 VAL R O   1 
ATOM   386  C CB  . VAL A 1 183 ? 119.968 151.815 154.258 1.00 73.57  ?  168 VAL R CB  1 
ATOM   387  C CG1 . VAL A 1 183 ? 119.349 151.531 155.616 1.00 73.57  ?  168 VAL R CG1 1 
ATOM   388  C CG2 . VAL A 1 183 ? 119.268 150.985 153.200 1.00 73.57  ?  168 VAL R CG2 1 
ATOM   389  N N   . ILE A 1 184 ? 121.722 154.361 155.155 1.00 74.54  ?  169 ILE R N   1 
ATOM   390  C CA  . ILE A 1 184 ? 122.276 155.290 156.137 1.00 74.54  ?  169 ILE R CA  1 
ATOM   391  C C   . ILE A 1 184 ? 121.926 156.736 155.826 1.00 74.54  ?  169 ILE R C   1 
ATOM   392  O O   . ILE A 1 184 ? 121.646 157.511 156.751 1.00 74.54  ?  169 ILE R O   1 
ATOM   393  C CB  . ILE A 1 184 ? 123.800 155.063 156.205 1.00 74.54  ?  169 ILE R CB  1 
ATOM   394  C CG1 . ILE A 1 184 ? 124.084 153.646 156.692 1.00 74.54  ?  169 ILE R CG1 1 
ATOM   395  C CG2 . ILE A 1 184 ? 124.485 156.042 157.134 1.00 74.54  ?  169 ILE R CG2 1 
ATOM   396  C CD1 . ILE A 1 184 ? 125.522 153.242 156.589 1.00 74.54  ?  169 ILE R CD1 1 
ATOM   397  N N   . PHE A 1 185 ? 121.850 157.106 154.549 1.00 76.47  ?  170 PHE R N   1 
ATOM   398  C CA  . PHE A 1 185 ? 121.526 158.474 154.165 1.00 76.47  ?  170 PHE R CA  1 
ATOM   399  C C   . PHE A 1 185 ? 120.048 158.784 154.368 1.00 76.47  ?  170 PHE R C   1 
ATOM   400  O O   . PHE A 1 185 ? 119.702 159.873 154.826 1.00 76.47  ?  170 PHE R O   1 
ATOM   401  C CB  . PHE A 1 185 ? 121.918 158.737 152.706 1.00 76.47  ?  170 PHE R CB  1 
ATOM   402  C CG  . PHE A 1 185 ? 121.661 160.145 152.260 1.00 76.47  ?  170 PHE R CG  1 
ATOM   403  C CD1 . PHE A 1 185 ? 122.520 161.163 152.615 1.00 76.47  ?  170 PHE R CD1 1 
ATOM   404  C CD2 . PHE A 1 185 ? 120.546 160.455 151.505 1.00 76.47  ?  170 PHE R CD2 1 
ATOM   405  C CE1 . PHE A 1 185 ? 122.281 162.460 152.213 1.00 76.47  ?  170 PHE R CE1 1 
ATOM   406  C CE2 . PHE A 1 185 ? 120.299 161.748 151.103 1.00 76.47  ?  170 PHE R CE2 1 
ATOM   407  C CZ  . PHE A 1 185 ? 121.167 162.751 151.458 1.00 76.47  ?  170 PHE R CZ  1 
ATOM   408  N N   . VAL A 1 186 ? 119.165 157.842 154.046 1.00 75.44  ?  171 VAL R N   1 
ATOM   409  C CA  . VAL A 1 186 ? 117.729 158.096 154.085 1.00 75.44  ?  171 VAL R CA  1 
ATOM   410  C C   . VAL A 1 186 ? 117.264 158.000 155.536 1.00 75.44  ?  171 VAL R C   1 
ATOM   411  O O   . VAL A 1 186 ? 116.214 158.533 155.908 1.00 75.44  ?  171 VAL R O   1 
ATOM   412  C CB  . VAL A 1 186 ? 116.999 157.117 153.141 1.00 75.44  ?  171 VAL R CB  1 
ATOM   413  C CG1 . VAL A 1 186 ? 115.499 157.368 153.064 1.00 75.44  ?  171 VAL R CG1 1 
ATOM   414  C CG2 . VAL A 1 186 ? 117.593 157.222 151.759 1.00 75.44  ?  171 VAL R CG2 1 
ATOM   415  N N   . TYR A 1 187 ? 118.082 157.412 156.385 1.00 77.29  ?  172 TYR R N   1 
ATOM   416  C CA  . TYR A 1 187 ? 117.777 157.405 157.811 1.00 77.29  ?  172 TYR R CA  1 
ATOM   417  C C   . TYR A 1 187 ? 118.333 158.617 158.540 1.00 77.29  ?  172 TYR R C   1 
ATOM   418  O O   . TYR A 1 187 ? 117.708 159.086 159.490 1.00 77.29  ?  172 TYR R O   1 
ATOM   419  C CB  . TYR A 1 187 ? 118.305 156.118 158.461 1.00 77.29  ?  172 TYR R CB  1 
ATOM   420  C CG  . TYR A 1 187 ? 118.136 156.074 159.956 1.00 77.29  ?  172 TYR R CG  1 
ATOM   421  C CD1 . TYR A 1 187 ? 116.875 155.971 160.526 1.00 77.29  ?  172 TYR R CD1 1 
ATOM   422  C CD2 . TYR A 1 187 ? 119.237 156.119 160.797 1.00 77.29  ?  172 TYR R CD2 1 
ATOM   423  C CE1 . TYR A 1 187 ? 116.714 155.931 161.894 1.00 77.29  ?  172 TYR R CE1 1 
ATOM   424  C CE2 . TYR A 1 187 ? 119.089 156.075 162.164 1.00 77.29  ?  172 TYR R CE2 1 
ATOM   425  C CZ  . TYR A 1 187 ? 117.825 155.980 162.707 1.00 77.29  ?  172 TYR R CZ  1 
ATOM   426  O OH  . TYR A 1 187 ? 117.668 155.935 164.071 1.00 77.29  ?  172 TYR R OH  1 
ATOM   427  N N   . SER A 1 188 ? 119.477 159.149 158.108 1.00 76.67  ?  173 SER R N   1 
ATOM   428  C CA  . SER A 1 188 ? 120.060 160.302 158.787 1.00 76.67  ?  173 SER R CA  1 
ATOM   429  C C   . SER A 1 188 ? 119.387 161.602 158.364 1.00 76.67  ?  173 SER R C   1 
ATOM   430  O O   . SER A 1 188 ? 119.158 162.488 159.194 1.00 76.67  ?  173 SER R O   1 
ATOM   431  C CB  . SER A 1 188 ? 121.559 160.371 158.505 1.00 76.67  ?  173 SER R CB  1 
ATOM   432  O OG  . SER A 1 188 ? 122.233 159.247 159.038 1.00 76.67  ?  173 SER R OG  1 
ATOM   433  N N   . PHE A 1 189 ? 119.073 161.732 157.076 1.00 80.40  ?  174 PHE R N   1 
ATOM   434  C CA  . PHE A 1 189 ? 118.553 162.975 156.520 1.00 80.40  ?  174 PHE R CA  1 
ATOM   435  C C   . PHE A 1 189 ? 117.114 163.217 156.945 1.00 80.40  ?  174 PHE R C   1 
ATOM   436  O O   . PHE A 1 189 ? 116.684 164.367 157.062 1.00 80.40  ?  174 PHE R O   1 
ATOM   437  C CB  . PHE A 1 189 ? 118.653 162.962 154.997 1.00 80.40  ?  174 PHE R CB  1 
ATOM   438  C CG  . PHE A 1 189 ? 118.346 164.279 154.364 1.00 80.40  ?  174 PHE R CG  1 
ATOM   439  C CD1 . PHE A 1 189 ? 119.286 165.297 154.376 1.00 80.40  ?  174 PHE R CD1 1 
ATOM   440  C CD2 . PHE A 1 189 ? 117.123 164.509 153.758 1.00 80.40  ?  174 PHE R CD2 1 
ATOM   441  C CE1 . PHE A 1 189 ? 119.017 166.516 153.793 1.00 80.40  ?  174 PHE R CE1 1 
ATOM   442  C CE2 . PHE A 1 189 ? 116.843 165.730 153.173 1.00 80.40  ?  174 PHE R CE2 1 
ATOM   443  C CZ  . PHE A 1 189 ? 117.792 166.734 153.192 1.00 80.40  ?  174 PHE R CZ  1 
ATOM   444  N N   . ILE A 1 190 ? 116.355 162.144 157.166 1.00 81.04  ?  175 ILE R N   1 
ATOM   445  C CA  . ILE A 1 190 ? 114.964 162.258 157.590 1.00 81.04  ?  175 ILE R CA  1 
ATOM   446  C C   . ILE A 1 190 ? 114.943 162.444 159.106 1.00 81.04  ?  175 ILE R C   1 
ATOM   447  O O   . ILE A 1 190 ? 113.901 162.734 159.704 1.00 81.04  ?  175 ILE R O   1 
ATOM   448  C CB  . ILE A 1 190 ? 114.152 161.028 157.137 1.00 81.04  ?  175 ILE R CB  1 
ATOM   449  C CG1 . ILE A 1 190 ? 112.671 161.361 156.998 1.00 81.04  ?  175 ILE R CG1 1 
ATOM   450  C CG2 . ILE A 1 190 ? 114.286 159.892 158.133 1.00 81.04  ?  175 ILE R CG2 1 
ATOM   451  C CD1 . ILE A 1 190 ? 111.885 160.319 156.249 1.00 81.04  ?  175 ILE R CD1 1 
ATOM   452  N N   . ASP A 1 191 ? 116.108 162.297 159.740 1.00 81.88  ?  176 ASP R N   1 
ATOM   453  C CA  . ASP A 1 191 ? 116.238 162.468 161.184 1.00 81.88  ?  176 ASP R CA  1 
ATOM   454  C C   . ASP A 1 191 ? 116.672 163.890 161.513 1.00 81.88  ?  176 ASP R C   1 
ATOM   455  O O   . ASP A 1 191 ? 116.313 164.404 162.571 1.00 81.88  ?  176 ASP R O   1 
ATOM   456  C CB  . ASP A 1 191 ? 117.231 161.442 161.734 1.00 81.88  ?  176 ASP R CB  1 
ATOM   457  C CG  . ASP A 1 191 ? 117.099 161.232 163.227 1.00 81.88  ?  176 ASP R CG  1 
ATOM   458  O OD1 . ASP A 1 191 ? 116.181 161.810 163.834 1.00 81.88  ?  176 ASP R OD1 1 
ATOM   459  O OD2 . ASP A 1 191 ? 117.921 160.487 163.796 1.00 81.88  -1 176 ASP R OD2 1 
ATOM   460  N N   . PHE A 1 192 ? 117.449 164.544 160.649 1.00 81.88  ?  177 PHE R N   1 
ATOM   461  C CA  . PHE A 1 192 ? 118.124 165.764 161.073 1.00 81.88  ?  177 PHE R CA  1 
ATOM   462  C C   . PHE A 1 192 ? 117.316 167.020 160.764 1.00 81.88  ?  177 PHE R C   1 
ATOM   463  O O   . PHE A 1 192 ? 117.334 167.967 161.556 1.00 81.88  ?  177 PHE R O   1 
ATOM   464  C CB  . PHE A 1 192 ? 119.507 165.822 160.435 1.00 81.88  ?  177 PHE R CB  1 
ATOM   465  C CG  . PHE A 1 192 ? 120.350 166.954 160.917 1.00 81.88  ?  177 PHE R CG  1 
ATOM   466  C CD1 . PHE A 1 192 ? 120.794 166.987 162.222 1.00 81.88  ?  177 PHE R CD1 1 
ATOM   467  C CD2 . PHE A 1 192 ? 120.754 167.949 160.051 1.00 81.88  ?  177 PHE R CD2 1 
ATOM   468  C CE1 . PHE A 1 192 ? 121.585 168.018 162.668 1.00 81.88  ?  177 PHE R CE1 1 
ATOM   469  C CE2 . PHE A 1 192 ? 121.551 168.978 160.489 1.00 81.88  ?  177 PHE R CE2 1 
ATOM   470  C CZ  . PHE A 1 192 ? 121.966 169.011 161.798 1.00 81.88  ?  177 PHE R CZ  1 
ATOM   471  N N   . HIS A 1 193 ? 116.604 167.059 159.635 1.00 81.09  ?  178 HIS R N   1 
ATOM   472  C CA  . HIS A 1 193 ? 115.857 168.252 159.247 1.00 81.09  ?  178 HIS R CA  1 
ATOM   473  C C   . HIS A 1 193 ? 114.376 168.151 159.590 1.00 81.09  ?  178 HIS R C   1 
ATOM   474  O O   . HIS A 1 193 ? 113.870 168.953 160.376 1.00 81.09  ?  178 HIS R O   1 
ATOM   475  C CB  . HIS A 1 193 ? 116.037 168.529 157.750 1.00 81.09  ?  178 HIS R CB  1 
ATOM   476  C CG  . HIS A 1 193 ? 117.433 168.908 157.373 1.00 81.09  ?  178 HIS R CG  1 
ATOM   477  N ND1 . HIS A 1 193 ? 118.359 167.991 156.927 1.00 81.09  ?  178 HIS R ND1 1 
ATOM   478  C CD2 . HIS A 1 193 ? 118.069 170.102 157.398 1.00 81.09  ?  178 HIS R CD2 1 
ATOM   479  C CE1 . HIS A 1 193 ? 119.500 168.607 156.679 1.00 81.09  ?  178 HIS R CE1 1 
ATOM   480  N NE2 . HIS A 1 193 ? 119.351 169.888 156.957 1.00 81.09  ?  178 HIS R NE2 1 
ATOM   481  N N   . VAL A 1 194 ? 113.664 167.179 159.023 1.00 84.90  ?  179 VAL R N   1 
ATOM   482  C CA  . VAL A 1 194 ? 112.336 166.805 159.499 1.00 84.90  ?  179 VAL R CA  1 
ATOM   483  C C   . VAL A 1 194 ? 112.625 165.880 160.678 1.00 84.90  ?  179 VAL R C   1 
ATOM   484  O O   . VAL A 1 194 ? 113.769 165.430 160.819 1.00 84.90  ?  179 VAL R O   1 
ATOM   485  C CB  . VAL A 1 194 ? 111.482 166.165 158.383 1.00 84.90  ?  179 VAL R CB  1 
ATOM   486  C CG1 . VAL A 1 194 ? 111.930 164.768 158.084 1.00 84.90  ?  179 VAL R CG1 1 
ATOM   487  C CG2 . VAL A 1 194 ? 109.982 166.242 158.676 1.00 84.90  ?  179 VAL R CG2 1 
ATOM   488  N N   . PHE A 1 195 ? 111.593 165.479 161.438 1.00 85.94  ?  180 PHE R N   1 
ATOM   489  C CA  . PHE A 1 195 ? 111.545 165.456 162.905 1.00 85.94  ?  180 PHE R CA  1 
ATOM   490  C C   . PHE A 1 195 ? 112.881 165.368 163.636 1.00 85.94  ?  180 PHE R C   1 
ATOM   491  O O   . PHE A 1 195 ? 113.638 164.407 163.479 1.00 85.94  ?  180 PHE R O   1 
ATOM   492  C CB  . PHE A 1 195 ? 110.660 164.278 163.334 1.00 85.94  ?  180 PHE R CB  1 
ATOM   493  C CG  . PHE A 1 195 ? 110.834 163.859 164.772 1.00 85.94  ?  180 PHE R CG  1 
ATOM   494  C CD1 . PHE A 1 195 ? 110.382 164.655 165.819 1.00 85.94  ?  180 PHE R CD1 1 
ATOM   495  C CD2 . PHE A 1 195 ? 111.423 162.638 165.071 1.00 85.94  ?  180 PHE R CD2 1 
ATOM   496  C CE1 . PHE A 1 195 ? 110.545 164.250 167.136 1.00 85.94  ?  180 PHE R CE1 1 
ATOM   497  C CE2 . PHE A 1 195 ? 111.582 162.228 166.379 1.00 85.94  ?  180 PHE R CE2 1 
ATOM   498  C CZ  . PHE A 1 195 ? 111.142 163.034 167.414 1.00 85.94  ?  180 PHE R CZ  1 
ATOM   499  N N   . HIS A 1 196 ? 113.108 166.347 164.510 1.00 85.22  ?  181 HIS R N   1 
ATOM   500  C CA  . HIS A 1 196 ? 114.421 166.787 164.951 1.00 85.22  ?  181 HIS R CA  1 
ATOM   501  C C   . HIS A 1 196 ? 115.040 165.825 165.956 1.00 85.22  ?  181 HIS R C   1 
ATOM   502  O O   . HIS A 1 196 ? 114.346 165.120 166.693 1.00 85.22  ?  181 HIS R O   1 
ATOM   503  C CB  . HIS A 1 196 ? 114.319 168.175 165.574 1.00 85.22  ?  181 HIS R CB  1 
ATOM   504  C CG  . HIS A 1 196 ? 113.880 169.237 164.617 1.00 85.22  ?  181 HIS R CG  1 
ATOM   505  N ND1 . HIS A 1 196 ? 114.724 169.784 163.676 1.00 85.22  ?  181 HIS R ND1 1 
ATOM   506  C CD2 . HIS A 1 196 ? 112.687 169.856 164.458 1.00 85.22  ?  181 HIS R CD2 1 
ATOM   507  C CE1 . HIS A 1 196 ? 114.070 170.696 162.979 1.00 85.22  ?  181 HIS R CE1 1 
ATOM   508  N NE2 . HIS A 1 196 ? 112.832 170.758 163.432 1.00 85.22  ?  181 HIS R NE2 1 
ATOM   509  N N   . ARG A 1 197 ? 116.374 165.825 165.987 1.00 82.91  ?  182 ARG R N   1 
ATOM   510  C CA  . ARG A 1 197 ? 117.143 165.000 166.907 1.00 82.91  ?  182 ARG R CA  1 
ATOM   511  C C   . ARG A 1 197 ? 118.536 165.595 167.053 1.00 82.91  ?  182 ARG R C   1 
ATOM   512  O O   . ARG A 1 197 ? 119.091 166.124 166.088 1.00 82.91  ?  182 ARG R O   1 
ATOM   513  C CB  . ARG A 1 197 ? 117.217 163.553 166.405 1.00 82.91  ?  182 ARG R CB  1 
ATOM   514  C CG  . ARG A 1 197 ? 117.767 162.559 167.401 1.00 82.91  ?  182 ARG R CG  1 
ATOM   515  C CD  . ARG A 1 197 ? 117.658 161.143 166.872 1.00 82.91  ?  182 ARG R CD  1 
ATOM   516  N NE  . ARG A 1 197 ? 116.266 160.747 166.692 1.00 82.91  ?  182 ARG R NE  1 
ATOM   517  C CZ  . ARG A 1 197 ? 115.489 160.278 167.663 1.00 82.91  ?  182 ARG R CZ  1 
ATOM   518  N NH1 . ARG A 1 197 ? 114.235 159.943 167.402 1.00 82.91  ?  182 ARG R NH1 1 
ATOM   519  N NH2 . ARG A 1 197 ? 115.957 160.146 168.894 1.00 82.91  ?  182 ARG R NH2 1 
ATOM   520  N N   . LYS A 1 198 ? 119.093 165.508 168.258 1.00 84.85  ?  183 LYS R N   1 
ATOM   521  C CA  . LYS A 1 198 ? 120.426 166.012 168.563 1.00 84.85  ?  183 LYS R CA  1 
ATOM   522  C C   . LYS A 1 198 ? 121.398 164.853 168.762 1.00 84.85  ?  183 LYS R C   1 
ATOM   523  O O   . LYS A 1 198 ? 121.006 163.684 168.815 1.00 84.85  ?  183 LYS R O   1 
ATOM   524  C CB  . LYS A 1 198 ? 120.394 166.909 169.805 1.00 84.85  ?  183 LYS R CB  1 
ATOM   525  N N   . ASP A 1 199 ? 122.682 165.190 168.874 1.00 84.73  ?  184 ASP R N   1 
ATOM   526  C CA  . ASP A 1 199 ? 123.723 164.169 168.977 1.00 84.73  ?  184 ASP R CA  1 
ATOM   527  C C   . ASP A 1 199 ? 124.928 164.770 169.704 1.00 84.73  ?  184 ASP R C   1 
ATOM   528  O O   . ASP A 1 199 ? 124.821 165.848 170.294 1.00 84.73  ?  184 ASP R O   1 
ATOM   529  C CB  . ASP A 1 199 ? 124.051 163.629 167.570 1.00 84.73  ?  184 ASP R CB  1 
ATOM   530  N N   . SER A 1 200 ? 126.063 164.075 169.662 1.00 79.39  ?  185 SER R N   1 
ATOM   531  C CA  . SER A 1 200 ? 127.292 164.539 170.298 1.00 79.39  ?  185 SER R CA  1 
ATOM   532  C C   . SER A 1 200 ? 128.447 164.307 169.333 1.00 79.39  ?  185 SER R C   1 
ATOM   533  O O   . SER A 1 200 ? 128.253 163.867 168.198 1.00 79.39  ?  185 SER R O   1 
ATOM   534  C CB  . SER A 1 200 ? 127.536 163.834 171.634 1.00 79.39  ?  185 SER R CB  1 
ATOM   535  O OG  . SER A 1 200 ? 127.819 162.459 171.443 1.00 79.39  ?  185 SER R OG  1 
ATOM   536  N N   . ARG A 1 201 ? 129.664 164.573 169.805 1.00 79.10  ?  186 ARG R N   1 
ATOM   537  C CA  . ARG A 1 201 ? 130.824 164.643 168.922 1.00 79.10  ?  186 ARG R CA  1 
ATOM   538  C C   . ARG A 1 201 ? 131.380 163.278 168.534 1.00 79.10  ?  186 ARG R C   1 
ATOM   539  O O   . ARG A 1 201 ? 132.364 163.202 167.793 1.00 79.10  ?  186 ARG R O   1 
ATOM   540  C CB  . ARG A 1 201 ? 131.931 165.476 169.573 1.00 79.10  ?  186 ARG R CB  1 
ATOM   541  N N   . ASN A 1 202 ? 130.769 162.198 169.019 1.00 79.08  ?  187 ASN R N   1 
ATOM   542  C CA  . ASN A 1 202 ? 131.236 160.854 168.699 1.00 79.08  ?  187 ASN R CA  1 
ATOM   543  C C   . ASN A 1 202 ? 130.083 159.997 168.195 1.00 79.08  ?  187 ASN R C   1 
ATOM   544  O O   . ASN A 1 202 ? 130.297 158.981 167.528 1.00 79.08  ?  187 ASN R O   1 
ATOM   545  C CB  . ASN A 1 202 ? 131.895 160.205 169.919 1.00 79.08  ?  187 ASN R CB  1 
ATOM   546  N N   . VAL A 1 203 ? 128.854 160.394 168.527 1.00 77.10  ?  188 VAL R N   1 
ATOM   547  C CA  . VAL A 1 203 ? 127.681 159.691 168.023 1.00 77.10  ?  188 VAL R CA  1 
ATOM   548  C C   . VAL A 1 203 ? 127.348 160.155 166.613 1.00 77.10  ?  188 VAL R C   1 
ATOM   549  O O   . VAL A 1 203 ? 126.980 159.346 165.754 1.00 77.10  ?  188 VAL R O   1 
ATOM   550  C CB  . VAL A 1 203 ? 126.501 159.899 168.991 1.00 77.10  ?  188 VAL R CB  1 
ATOM   551  C CG1 . VAL A 1 203 ? 125.237 159.217 168.485 1.00 77.10  ?  188 VAL R CG1 1 
ATOM   552  C CG2 . VAL A 1 203 ? 126.873 159.403 170.379 1.00 77.10  ?  188 VAL R CG2 1 
ATOM   553  N N   . PHE A 1 204 ? 127.513 161.450 166.337 1.00 78.59  ?  189 PHE R N   1 
ATOM   554  C CA  . PHE A 1 204 ? 127.110 162.024 165.058 1.00 78.59  ?  189 PHE R CA  1 
ATOM   555  C C   . PHE A 1 204 ? 128.125 161.724 163.965 1.00 78.59  ?  189 PHE R C   1 
ATOM   556  O O   . PHE A 1 204 ? 127.745 161.437 162.826 1.00 78.59  ?  189 PHE R O   1 
ATOM   557  C CB  . PHE A 1 204 ? 126.916 163.537 165.179 1.00 78.59  ?  189 PHE R CB  1 
ATOM   558  C CG  . PHE A 1 204 ? 126.366 164.179 163.937 1.00 78.59  ?  189 PHE R CG  1 
ATOM   559  C CD1 . PHE A 1 204 ? 125.020 164.066 163.628 1.00 78.59  ?  189 PHE R CD1 1 
ATOM   560  C CD2 . PHE A 1 204 ? 127.192 164.893 163.080 1.00 78.59  ?  189 PHE R CD2 1 
ATOM   561  C CE1 . PHE A 1 204 ? 124.506 164.649 162.492 1.00 78.59  ?  189 PHE R CE1 1 
ATOM   562  C CE2 . PHE A 1 204 ? 126.682 165.478 161.938 1.00 78.59  ?  189 PHE R CE2 1 
ATOM   563  C CZ  . PHE A 1 204 ? 125.336 165.355 161.647 1.00 78.59  ?  189 PHE R CZ  1 
ATOM   564  N N   . LEU A 1 205 ? 129.414 161.787 164.293 1.00 76.60  ?  190 LEU R N   1 
ATOM   565  C CA  . LEU A 1 205 ? 130.457 161.538 163.305 1.00 76.60  ?  190 LEU R CA  1 
ATOM   566  C C   . LEU A 1 205 ? 130.536 160.068 162.907 1.00 76.60  ?  190 LEU R C   1 
ATOM   567  O O   . LEU A 1 205 ? 131.152 159.732 161.892 1.00 76.60  ?  190 LEU R O   1 
ATOM   568  C CB  . LEU A 1 205 ? 131.818 162.009 163.819 1.00 76.60  ?  190 LEU R CB  1 
ATOM   569  C CG  . LEU A 1 205 ? 132.200 163.486 163.678 1.00 76.60  ?  190 LEU R CG  1 
ATOM   570  C CD1 . LEU A 1 205 ? 131.499 164.369 164.690 1.00 76.60  ?  190 LEU R CD1 1 
ATOM   571  C CD2 . LEU A 1 205 ? 133.707 163.652 163.778 1.00 76.60  ?  190 LEU R CD2 1 
ATOM   572  N N   . PHE A 1 206 ? 129.926 159.182 163.696 1.00 80.22  ?  191 PHE R N   1 
ATOM   573  C CA  . PHE A 1 206 ? 129.802 157.780 163.323 1.00 80.22  ?  191 PHE R CA  1 
ATOM   574  C C   . PHE A 1 206 ? 128.748 157.545 162.251 1.00 80.22  ?  191 PHE R C   1 
ATOM   575  O O   . PHE A 1 206 ? 128.947 156.680 161.394 1.00 80.22  ?  191 PHE R O   1 
ATOM   576  C CB  . PHE A 1 206 ? 129.481 156.929 164.559 1.00 80.22  ?  191 PHE R CB  1 
ATOM   577  C CG  . PHE A 1 206 ? 129.299 155.464 164.268 1.00 80.22  ?  191 PHE R CG  1 
ATOM   578  C CD1 . PHE A 1 206 ? 130.387 154.661 163.976 1.00 80.22  ?  191 PHE R CD1 1 
ATOM   579  C CD2 . PHE A 1 206 ? 128.034 154.885 164.308 1.00 80.22  ?  191 PHE R CD2 1 
ATOM   580  C CE1 . PHE A 1 206 ? 130.219 153.311 163.712 1.00 80.22  ?  191 PHE R CE1 1 
ATOM   581  C CE2 . PHE A 1 206 ? 127.859 153.537 164.046 1.00 80.22  ?  191 PHE R CE2 1 
ATOM   582  C CZ  . PHE A 1 206 ? 128.953 152.750 163.748 1.00 80.22  ?  191 PHE R CZ  1 
ATOM   583  N N   . LYS A 1 207 ? 127.643 158.291 162.268 1.00 72.94  ?  192 LYS R N   1 
ATOM   584  C CA  . LYS A 1 207 ? 126.675 158.187 161.181 1.00 72.94  ?  192 LYS R CA  1 
ATOM   585  C C   . LYS A 1 207 ? 127.159 158.932 159.945 1.00 72.94  ?  192 LYS R C   1 
ATOM   586  O O   . LYS A 1 207 ? 126.744 158.624 158.824 1.00 72.94  ?  192 LYS R O   1 
ATOM   587  C CB  . LYS A 1 207 ? 125.312 158.714 161.627 1.00 72.94  ?  192 LYS R CB  1 
ATOM   588  C CG  . LYS A 1 207 ? 124.611 157.821 162.619 1.00 72.94  ?  192 LYS R CG  1 
ATOM   589  C CD  . LYS A 1 207 ? 123.197 158.284 162.886 1.00 72.94  ?  192 LYS R CD  1 
ATOM   590  C CE  . LYS A 1 207 ? 123.181 159.500 163.777 1.00 72.94  ?  192 LYS R CE  1 
ATOM   591  N NZ  . LYS A 1 207 ? 121.796 159.846 164.178 1.00 72.94  ?  192 LYS R NZ  1 
ATOM   592  N N   . LEU A 1 208 ? 128.045 159.906 160.129 1.00 71.13  ?  193 LEU R N   1 
ATOM   593  C CA  . LEU A 1 208 ? 128.561 160.691 159.016 1.00 71.13  ?  193 LEU R CA  1 
ATOM   594  C C   . LEU A 1 208 ? 129.713 159.950 158.350 1.00 71.13  ?  193 LEU R C   1 
ATOM   595  O O   . LEU A 1 208 ? 130.144 160.306 157.250 1.00 71.13  ?  193 LEU R O   1 
ATOM   596  C CB  . LEU A 1 208 ? 128.991 162.071 159.516 1.00 71.13  ?  193 LEU R CB  1 
ATOM   597  C CG  . LEU A 1 208 ? 129.438 163.184 158.575 1.00 71.13  ?  193 LEU R CG  1 
ATOM   598  C CD1 . LEU A 1 208 ? 128.343 163.499 157.593 1.00 71.13  ?  193 LEU R CD1 1 
ATOM   599  C CD2 . LEU A 1 208 ? 129.749 164.396 159.404 1.00 71.13  ?  193 LEU R CD2 1 
ATOM   600  N N   . GLY A 1 209 ? 130.194 158.890 158.991 1.00 70.17  ?  194 GLY R N   1 
ATOM   601  C CA  . GLY A 1 209 ? 131.227 158.066 158.403 1.00 70.17  ?  194 GLY R CA  1 
ATOM   602  C C   . GLY A 1 209 ? 130.632 156.913 157.625 1.00 70.17  ?  194 GLY R C   1 
ATOM   603  O O   . GLY A 1 209 ? 131.356 156.106 157.038 1.00 70.17  ?  194 GLY R O   1 
ATOM   604  N N   . GLY A 1 210 ? 129.307 156.827 157.616 1.00 68.04  ?  195 GLY R N   1 
ATOM   605  C CA  . GLY A 1 210 ? 128.622 155.807 156.852 1.00 68.04  ?  195 GLY R CA  1 
ATOM   606  C C   . GLY A 1 210 ? 127.912 156.377 155.644 1.00 68.04  ?  195 GLY R C   1 
ATOM   607  O O   . GLY A 1 210 ? 127.095 155.701 155.014 1.00 68.04  ?  195 GLY R O   1 
ATOM   608  N N   . VAL A 1 211 ? 128.212 157.630 155.315 1.00 67.97  ?  196 VAL R N   1 
ATOM   609  C CA  . VAL A 1 211 ? 127.673 158.257 154.116 1.00 67.97  ?  196 VAL R CA  1 
ATOM   610  C C   . VAL A 1 211 ? 128.845 158.891 153.377 1.00 67.97  ?  196 VAL R C   1 
ATOM   611  O O   . VAL A 1 211 ? 128.731 159.279 152.210 1.00 67.97  ?  196 VAL R O   1 
ATOM   612  C CB  . VAL A 1 211 ? 126.578 159.282 154.464 1.00 67.97  ?  196 VAL R CB  1 
ATOM   613  C CG1 . VAL A 1 211 ? 127.180 160.557 155.020 1.00 67.97  ?  196 VAL R CG1 1 
ATOM   614  C CG2 . VAL A 1 211 ? 125.673 159.545 153.278 1.00 67.97  ?  196 VAL R CG2 1 
ATOM   615  N N   . THR A 1 212 ? 129.992 158.975 154.049 1.00 68.58  ?  197 THR R N   1 
ATOM   616  C CA  . THR A 1 212 ? 131.233 159.407 153.427 1.00 68.58  ?  197 THR R CA  1 
ATOM   617  C C   . THR A 1 212 ? 132.031 158.238 152.871 1.00 68.58  ?  197 THR R C   1 
ATOM   618  O O   . THR A 1 212 ? 132.611 158.359 151.789 1.00 68.58  ?  197 THR R O   1 
ATOM   619  C CB  . THR A 1 212 ? 132.079 160.183 154.443 1.00 68.58  ?  197 THR R CB  1 
ATOM   620  O OG1 . THR A 1 212 ? 131.305 161.269 154.959 1.00 68.58  ?  197 THR R OG1 1 
ATOM   621  C CG2 . THR A 1 212 ? 133.333 160.755 153.808 1.00 68.58  ?  197 THR R CG2 1 
ATOM   622  N N   . ALA A 1 213 ? 132.021 157.092 153.548 1.00 66.68  ?  198 ALA R N   1 
ATOM   623  C CA  . ALA A 1 213 ? 132.666 155.892 153.044 1.00 66.68  ?  198 ALA R CA  1 
ATOM   624  C C   . ALA A 1 213 ? 131.799 155.108 152.073 1.00 66.68  ?  198 ALA R C   1 
ATOM   625  O O   . ALA A 1 213 ? 132.273 154.116 151.514 1.00 66.68  ?  198 ALA R O   1 
ATOM   626  C CB  . ALA A 1 213 ? 133.073 154.975 154.205 1.00 66.68  ?  198 ALA R CB  1 
ATOM   627  N N   . SER A 1 214 ? 130.546 155.514 151.863 1.00 66.75  ?  199 SER R N   1 
ATOM   628  C CA  . SER A 1 214 ? 129.664 154.867 150.901 1.00 66.75  ?  199 SER R CA  1 
ATOM   629  C C   . SER A 1 214 ? 129.358 155.758 149.703 1.00 66.75  ?  199 SER R C   1 
ATOM   630  O O   . SER A 1 214 ? 128.643 155.335 148.792 1.00 66.75  ?  199 SER R O   1 
ATOM   631  C CB  . SER A 1 214 ? 128.370 154.427 151.579 1.00 66.75  ?  199 SER R CB  1 
ATOM   632  O OG  . SER A 1 214 ? 128.630 153.436 152.553 1.00 66.75  ?  199 SER R OG  1 
ATOM   633  N N   . PHE A 1 215 ? 129.878 156.988 149.689 1.00 66.96  ?  200 PHE R N   1 
ATOM   634  C CA  . PHE A 1 215 ? 129.805 157.823 148.496 1.00 66.96  ?  200 PHE R CA  1 
ATOM   635  C C   . PHE A 1 215 ? 131.164 158.016 147.844 1.00 66.96  ?  200 PHE R C   1 
ATOM   636  O O   . PHE A 1 215 ? 131.255 158.746 146.853 1.00 66.96  ?  200 PHE R O   1 
ATOM   637  C CB  . PHE A 1 215 ? 129.198 159.198 148.791 1.00 66.96  ?  200 PHE R CB  1 
ATOM   638  C CG  . PHE A 1 215 ? 127.707 159.192 148.940 1.00 66.96  ?  200 PHE R CG  1 
ATOM   639  C CD1 . PHE A 1 215 ? 126.961 158.076 148.599 1.00 66.96  ?  200 PHE R CD1 1 
ATOM   640  C CD2 . PHE A 1 215 ? 127.046 160.327 149.375 1.00 66.96  ?  200 PHE R CD2 1 
ATOM   641  C CE1 . PHE A 1 215 ? 125.588 158.079 148.725 1.00 66.96  ?  200 PHE R CE1 1 
ATOM   642  C CE2 . PHE A 1 215 ? 125.672 160.338 149.498 1.00 66.96  ?  200 PHE R CE2 1 
ATOM   643  C CZ  . PHE A 1 215 ? 124.943 159.212 149.174 1.00 66.96  ?  200 PHE R CZ  1 
ATOM   644  N N   . THR A 1 216 ? 132.221 157.412 148.374 1.00 64.22  ?  201 THR R N   1 
ATOM   645  C CA  . THR A 1 216 ? 133.480 157.295 147.662 1.00 64.22  ?  201 THR R CA  1 
ATOM   646  C C   . THR A 1 216 ? 133.822 155.844 147.373 1.00 64.22  ?  201 THR R C   1 
ATOM   647  O O   . THR A 1 216 ? 134.862 155.574 146.762 1.00 64.22  ?  201 THR R O   1 
ATOM   648  C CB  . THR A 1 216 ? 134.619 157.958 148.445 1.00 64.22  ?  201 THR R CB  1 
ATOM   649  O OG1 . THR A 1 216 ? 135.805 157.959 147.645 1.00 64.22  ?  201 THR R OG1 1 
ATOM   650  C CG2 . THR A 1 216 ? 134.890 157.211 149.718 1.00 64.22  ?  201 THR R CG2 1 
ATOM   651  N N   . ALA A 1 217 ? 132.977 154.906 147.801 1.00 64.61  ?  202 ALA R N   1 
ATOM   652  C CA  . ALA A 1 217 ? 133.005 153.533 147.318 1.00 64.61  ?  202 ALA R CA  1 
ATOM   653  C C   . ALA A 1 217 ? 131.968 153.325 146.223 1.00 64.61  ?  202 ALA R C   1 
ATOM   654  O O   . ALA A 1 217 ? 131.766 152.199 145.765 1.00 64.61  ?  202 ALA R O   1 
ATOM   655  C CB  . ALA A 1 217 ? 132.780 152.550 148.465 1.00 64.61  ?  202 ALA R CB  1 
ATOM   656  N N   . SER A 1 218 ? 131.304 154.402 145.802 1.00 63.07  ?  203 SER R N   1 
ATOM   657  C CA  . SER A 1 218 ? 130.466 154.381 144.612 1.00 63.07  ?  203 SER R CA  1 
ATOM   658  C C   . SER A 1 218 ? 131.021 155.283 143.520 1.00 63.07  ?  203 SER R C   1 
ATOM   659  O O   . SER A 1 218 ? 130.429 155.355 142.438 1.00 63.07  ?  203 SER R O   1 
ATOM   660  C CB  . SER A 1 218 ? 129.037 154.802 144.944 1.00 63.07  ?  203 SER R CB  1 
ATOM   661  O OG  . SER A 1 218 ? 128.250 154.865 143.771 1.00 63.07  ?  203 SER R OG  1 
ATOM   662  N N   . VAL A 1 219 ? 132.131 155.978 143.774 1.00 59.74  ?  204 VAL R N   1 
ATOM   663  C CA  . VAL A 1 219 ? 132.857 156.715 142.749 1.00 59.74  ?  204 VAL R CA  1 
ATOM   664  C C   . VAL A 1 219 ? 134.154 156.021 142.368 1.00 59.74  ?  204 VAL R C   1 
ATOM   665  O O   . VAL A 1 219 ? 134.536 156.041 141.197 1.00 59.74  ?  204 VAL R O   1 
ATOM   666  C CB  . VAL A 1 219 ? 133.125 158.167 143.209 1.00 59.74  ?  204 VAL R CB  1 
ATOM   667  C CG1 . VAL A 1 219 ? 133.882 158.990 142.172 1.00 59.74  ?  204 VAL R CG1 1 
ATOM   668  C CG2 . VAL A 1 219 ? 131.822 158.846 143.539 1.00 59.74  ?  204 VAL R CG2 1 
ATOM   669  N N   . GLY A 1 220 ? 134.787 155.311 143.296 1.00 57.81  ?  205 GLY R N   1 
ATOM   670  C CA  . GLY A 1 220 ? 135.953 154.519 142.971 1.00 57.81  ?  205 GLY R CA  1 
ATOM   671  C C   . GLY A 1 220 ? 135.597 153.275 142.185 1.00 57.81  ?  205 GLY R C   1 
ATOM   672  O O   . GLY A 1 220 ? 136.455 152.690 141.520 1.00 57.81  ?  205 GLY R O   1 
ATOM   673  N N   . SER A 1 221 ? 134.332 152.858 142.251 1.00 55.68  ?  206 SER R N   1 
ATOM   674  C CA  . SER A 1 221 ? 133.868 151.751 141.424 1.00 55.68  ?  206 SER R CA  1 
ATOM   675  C C   . SER A 1 221 ? 133.574 152.212 140.001 1.00 55.68  ?  206 SER R C   1 
ATOM   676  O O   . SER A 1 221 ? 133.641 151.422 139.055 1.00 55.68  ?  206 SER R O   1 
ATOM   677  C CB  . SER A 1 221 ? 132.635 151.105 142.053 1.00 55.68  ?  206 SER R CB  1 
ATOM   678  O OG  . SER A 1 221 ? 132.956 150.492 143.285 1.00 55.68  ?  206 SER R OG  1 
ATOM   679  N N   . LEU A 1 222 ? 133.256 153.496 139.826 1.00 55.62  ?  207 LEU R N   1 
ATOM   680  C CA  . LEU A 1 222 ? 133.067 154.059 138.493 1.00 55.62  ?  207 LEU R CA  1 
ATOM   681  C C   . LEU A 1 222 ? 134.411 154.355 137.845 1.00 55.62  ?  207 LEU R C   1 
ATOM   682  O O   . LEU A 1 222 ? 134.485 154.650 136.650 1.00 55.62  ?  207 LEU R O   1 
ATOM   683  C CB  . LEU A 1 222 ? 132.239 155.341 138.547 1.00 55.62  ?  207 LEU R CB  1 
ATOM   684  C CG  . LEU A 1 222 ? 130.809 155.237 139.058 1.00 55.62  ?  207 LEU R CG  1 
ATOM   685  C CD1 . LEU A 1 222 ? 130.148 156.601 139.074 1.00 55.62  ?  207 LEU R CD1 1 
ATOM   686  C CD2 . LEU A 1 222 ? 130.041 154.285 138.205 1.00 55.62  ?  207 LEU R CD2 1 
ATOM   687  N N   . PHE A 1 223 ? 135.478 154.288 138.637 1.00 55.92  ?  208 PHE R N   1 
ATOM   688  C CA  . PHE A 1 223 ? 136.837 154.454 138.151 1.00 55.92  ?  208 PHE R CA  1 
ATOM   689  C C   . PHE A 1 223 ? 137.433 153.118 137.730 1.00 55.92  ?  208 PHE R C   1 
ATOM   690  O O   . PHE A 1 223 ? 138.434 153.093 137.006 1.00 55.92  ?  208 PHE R O   1 
ATOM   691  C CB  . PHE A 1 223 ? 137.684 155.124 139.242 1.00 55.92  ?  208 PHE R CB  1 
ATOM   692  C CG  . PHE A 1 223 ? 139.106 155.367 138.862 1.00 55.92  ?  208 PHE R CG  1 
ATOM   693  C CD1 . PHE A 1 223 ? 139.432 156.341 137.943 1.00 55.92  ?  208 PHE R CD1 1 
ATOM   694  C CD2 . PHE A 1 223 ? 140.121 154.633 139.443 1.00 55.92  ?  208 PHE R CD2 1 
ATOM   695  C CE1 . PHE A 1 223 ? 140.746 156.569 137.598 1.00 55.92  ?  208 PHE R CE1 1 
ATOM   696  C CE2 . PHE A 1 223 ? 141.436 154.859 139.102 1.00 55.92  ?  208 PHE R CE2 1 
ATOM   697  C CZ  . PHE A 1 223 ? 141.747 155.829 138.177 1.00 55.92  ?  208 PHE R CZ  1 
ATOM   698  N N   . LEU A 1 224 ? 136.814 152.009 138.108 1.00 55.82  ?  209 LEU R N   1 
ATOM   699  C CA  . LEU A 1 224 ? 137.312 150.699 137.722 1.00 55.82  ?  209 LEU R CA  1 
ATOM   700  C C   . LEU A 1 224 ? 136.641 150.147 136.477 1.00 55.82  ?  209 LEU R C   1 
ATOM   701  O O   . LEU A 1 224 ? 137.275 149.405 135.727 1.00 55.82  ?  209 LEU R O   1 
ATOM   702  C CB  . LEU A 1 224 ? 137.155 149.710 138.882 1.00 55.82  ?  209 LEU R CB  1 
ATOM   703  C CG  . LEU A 1 224 ? 138.019 150.020 140.107 1.00 55.82  ?  209 LEU R CG  1 
ATOM   704  C CD1 . LEU A 1 224 ? 137.719 149.056 141.234 1.00 55.82  ?  209 LEU R CD1 1 
ATOM   705  C CD2 . LEU A 1 224 ? 139.494 149.989 139.755 1.00 55.82  ?  209 LEU R CD2 1 
ATOM   706  N N   . THR A 1 225 ? 135.377 150.496 136.220 1.00 54.70  ?  210 THR R N   1 
ATOM   707  C CA  . THR A 1 225 ? 134.810 150.129 134.921 1.00 54.70  ?  210 THR R CA  1 
ATOM   708  C C   . THR A 1 225 ? 135.232 151.062 133.823 1.00 54.70  ?  210 THR R C   1 
ATOM   709  O O   . THR A 1 225 ? 134.905 150.787 132.672 1.00 54.70  ?  210 THR R O   1 
ATOM   710  C CB  . THR A 1 225 ? 133.284 150.090 134.968 1.00 54.70  ?  210 THR R CB  1 
ATOM   711  O OG1 . THR A 1 225 ? 132.786 151.390 135.291 1.00 54.70  ?  210 THR R OG1 1 
ATOM   712  C CG2 . THR A 1 225 ? 132.809 149.124 136.002 1.00 54.70  ?  210 THR R CG2 1 
ATOM   713  N N   . ALA A 1 226 ? 135.936 152.159 134.100 1.00 52.58  ?  211 ALA R N   1 
ATOM   714  C CA  . ALA A 1 226 ? 136.441 153.035 133.051 1.00 52.58  ?  211 ALA R CA  1 
ATOM   715  C C   . ALA A 1 226 ? 137.945 152.880 132.892 1.00 52.58  ?  211 ALA R C   1 
ATOM   716  O O   . ALA A 1 226 ? 138.550 153.560 132.064 1.00 52.58  ?  211 ALA R O   1 
ATOM   717  C CB  . ALA A 1 226 ? 136.086 154.494 133.331 1.00 52.58  ?  211 ALA R CB  1 
ATOM   718  N N   . ILE A 1 227 ? 138.556 152.000 133.679 1.00 54.98  ?  212 ILE R N   1 
ATOM   719  C CA  . ILE A 1 227 ? 139.924 151.563 133.455 1.00 54.98  ?  212 ILE R CA  1 
ATOM   720  C C   . ILE A 1 227 ? 139.970 150.128 132.955 1.00 54.98  ?  212 ILE R C   1 
ATOM   721  O O   . ILE A 1 227 ? 141.007 149.683 132.458 1.00 54.98  ?  212 ILE R O   1 
ATOM   722  C CB  . ILE A 1 227 ? 140.776 151.738 134.732 1.00 54.98  ?  212 ILE R CB  1 
ATOM   723  C CG1 . ILE A 1 227 ? 142.266 151.880 134.408 1.00 54.98  ?  212 ILE R CG1 1 
ATOM   724  C CG2 . ILE A 1 227 ? 140.560 150.583 135.695 1.00 54.98  ?  212 ILE R CG2 1 
ATOM   725  C CD1 . ILE A 1 227 ? 143.084 152.420 135.556 1.00 54.98  ?  212 ILE R CD1 1 
ATOM   726  N N   . ASP A 1 228 ? 138.853 149.406 133.030 1.00 53.29  ?  213 ASP R N   1 
ATOM   727  C CA  . ASP A 1 228 ? 138.706 148.111 132.387 1.00 53.29  ?  213 ASP R CA  1 
ATOM   728  C C   . ASP A 1 228 ? 138.274 148.224 130.935 1.00 53.29  ?  213 ASP R C   1 
ATOM   729  O O   . ASP A 1 228 ? 138.674 147.388 130.121 1.00 53.29  ?  213 ASP R O   1 
ATOM   730  C CB  . ASP A 1 228 ? 137.687 147.261 133.148 1.00 53.29  ?  213 ASP R CB  1 
ATOM   731  C CG  . ASP A 1 228 ? 137.553 145.870 132.587 1.00 53.29  ?  213 ASP R CG  1 
ATOM   732  O OD1 . ASP A 1 228 ? 138.474 145.057 132.792 1.00 53.29  ?  213 ASP R OD1 1 
ATOM   733  O OD2 . ASP A 1 228 ? 136.524 145.585 131.945 1.00 53.29  -1 213 ASP R OD2 1 
ATOM   734  N N   . ARG A 1 229 ? 137.491 149.243 130.592 1.00 51.56  ?  214 ARG R N   1 
ATOM   735  C CA  . ARG A 1 229 ? 137.080 149.506 129.220 1.00 51.56  ?  214 ARG R CA  1 
ATOM   736  C C   . ARG A 1 229 ? 138.093 150.346 128.458 1.00 51.56  ?  214 ARG R C   1 
ATOM   737  O O   . ARG A 1 229 ? 137.813 150.755 127.329 1.00 51.56  ?  214 ARG R O   1 
ATOM   738  C CB  . ARG A 1 229 ? 135.721 150.209 129.205 1.00 51.56  ?  214 ARG R CB  1 
ATOM   739  C CG  . ARG A 1 229 ? 134.583 149.360 129.715 1.00 51.56  ?  214 ARG R CG  1 
ATOM   740  C CD  . ARG A 1 229 ? 133.290 150.146 129.759 1.00 51.56  ?  214 ARG R CD  1 
ATOM   741  N NE  . ARG A 1 229 ? 132.195 149.359 130.315 1.00 51.56  ?  214 ARG R NE  1 
ATOM   742  C CZ  . ARG A 1 229 ? 130.970 149.827 130.529 1.00 51.56  ?  214 ARG R CZ  1 
ATOM   743  N NH1 . ARG A 1 229 ? 130.038 149.038 131.039 1.00 51.56  ?  214 ARG R NH1 1 
ATOM   744  N NH2 . ARG A 1 229 ? 130.678 151.083 130.240 1.00 51.56  ?  214 ARG R NH2 1 
ATOM   745  N N   . TYR A 1 230 ? 139.249 150.627 129.052 1.00 53.16  ?  215 TYR R N   1 
ATOM   746  C CA  . TYR A 1 230 ? 140.316 151.376 128.409 1.00 53.16  ?  215 TYR R CA  1 
ATOM   747  C C   . TYR A 1 230 ? 141.470 150.475 127.991 1.00 53.16  ?  215 TYR R C   1 
ATOM   748  O O   . TYR A 1 230 ? 142.276 150.865 127.147 1.00 53.16  ?  215 TYR R O   1 
ATOM   749  C CB  . TYR A 1 230 ? 140.804 152.480 129.348 1.00 53.16  ?  215 TYR R CB  1 
ATOM   750  C CG  . TYR A 1 230 ? 141.891 153.363 128.796 1.00 53.16  ?  215 TYR R CG  1 
ATOM   751  C CD1 . TYR A 1 230 ? 141.608 154.336 127.857 1.00 53.16  ?  215 TYR R CD1 1 
ATOM   752  C CD2 . TYR A 1 230 ? 143.201 153.218 129.216 1.00 53.16  ?  215 TYR R CD2 1 
ATOM   753  C CE1 . TYR A 1 230 ? 142.598 155.143 127.356 1.00 53.16  ?  215 TYR R CE1 1 
ATOM   754  C CE2 . TYR A 1 230 ? 144.197 154.018 128.718 1.00 53.16  ?  215 TYR R CE2 1 
ATOM   755  C CZ  . TYR A 1 230 ? 143.890 154.979 127.789 1.00 53.16  ?  215 TYR R CZ  1 
ATOM   756  O OH  . TYR A 1 230 ? 144.885 155.783 127.290 1.00 53.16  ?  215 TYR R OH  1 
ATOM   757  N N   . ILE A 1 231 ? 141.539 149.258 128.521 1.00 53.47  ?  216 ILE R N   1 
ATOM   758  C CA  . ILE A 1 231 ? 142.624 148.347 128.181 1.00 53.47  ?  216 ILE R CA  1 
ATOM   759  C C   . ILE A 1 231 ? 141.985 147.263 127.320 1.00 53.47  ?  216 ILE R C   1 
ATOM   760  O O   . ILE A 1 231 ? 142.370 146.090 127.360 1.00 53.47  ?  216 ILE R O   1 
ATOM   761  C CB  . ILE A 1 231 ? 143.313 147.783 129.438 1.00 53.47  ?  216 ILE R CB  1 
ATOM   762  C CG1 . ILE A 1 231 ? 143.556 148.897 130.445 1.00 53.47  ?  216 ILE R CG1 1 
ATOM   763  C CG2 . ILE A 1 231 ? 144.722 147.296 129.122 1.00 53.47  ?  216 ILE R CG2 1 
ATOM   764  C CD1 . ILE A 1 231 ? 144.020 148.401 131.796 1.00 53.47  ?  216 ILE R CD1 1 
ATOM   765  N N   . SER A 1 232 ? 140.961 147.648 126.565 1.00 53.09  ?  217 SER R N   1 
ATOM   766  C CA  . SER A 1 232 ? 140.318 146.721 125.647 1.00 53.09  ?  217 SER R CA  1 
ATOM   767  C C   . SER A 1 232 ? 140.224 147.277 124.235 1.00 53.09  ?  217 SER R C   1 
ATOM   768  O O   . SER A 1 232 ? 139.874 146.526 123.319 1.00 53.09  ?  217 SER R O   1 
ATOM   769  C CB  . SER A 1 232 ? 138.922 146.357 126.135 1.00 53.09  ?  217 SER R CB  1 
ATOM   770  O OG  . SER A 1 232 ? 138.062 147.476 126.056 1.00 53.09  ?  217 SER R OG  1 
ATOM   771  N N   . ILE A 1 233 ? 140.500 148.565 124.028 1.00 52.76  ?  218 ILE R N   1 
ATOM   772  C CA  . ILE A 1 233 ? 140.472 149.156 122.693 1.00 52.76  ?  218 ILE R CA  1 
ATOM   773  C C   . ILE A 1 233 ? 141.828 149.810 122.446 1.00 52.76  ?  218 ILE R C   1 
ATOM   774  O O   . ILE A 1 233 ? 142.286 149.918 121.303 1.00 52.76  ?  218 ILE R O   1 
ATOM   775  C CB  . ILE A 1 233 ? 139.287 150.139 122.546 1.00 52.76  ?  218 ILE R CB  1 
ATOM   776  C CG1 . ILE A 1 233 ? 137.964 149.389 122.704 1.00 52.76  ?  218 ILE R CG1 1 
ATOM   777  C CG2 . ILE A 1 233 ? 139.234 150.793 121.181 1.00 52.76  ?  218 ILE R CG2 1 
ATOM   778  C CD1 . ILE A 1 233 ? 136.745 150.259 122.712 1.00 52.76  ?  218 ILE R CD1 1 
ATOM   779  N N   . HIS A 1 234 ? 142.534 150.151 123.519 1.00 56.31  ?  219 HIS R N   1 
ATOM   780  C CA  . HIS A 1 234 ? 143.885 150.684 123.397 1.00 56.31  ?  219 HIS R CA  1 
ATOM   781  C C   . HIS A 1 234 ? 144.938 149.614 123.162 1.00 56.31  ?  219 HIS R C   1 
ATOM   782  O O   . HIS A 1 234 ? 145.874 149.848 122.397 1.00 56.31  ?  219 HIS R O   1 
ATOM   783  C CB  . HIS A 1 234 ? 144.255 151.483 124.650 1.00 56.31  ?  219 HIS R CB  1 
ATOM   784  C CG  . HIS A 1 234 ? 145.655 152.006 124.653 1.00 56.31  ?  219 HIS R CG  1 
ATOM   785  N ND1 . HIS A 1 234 ? 146.070 153.035 123.837 1.00 56.31  ?  219 HIS R ND1 1 
ATOM   786  C CD2 . HIS A 1 234 ? 146.731 151.660 125.397 1.00 56.31  ?  219 HIS R CD2 1 
ATOM   787  C CE1 . HIS A 1 234 ? 147.345 153.290 124.067 1.00 56.31  ?  219 HIS R CE1 1 
ATOM   788  N NE2 . HIS A 1 234 ? 147.770 152.470 125.011 1.00 56.31  ?  219 HIS R NE2 1 
ATOM   789  N N   . ARG A 1 235 ? 144.811 148.453 123.801 1.00 57.45  ?  220 ARG R N   1 
ATOM   790  C CA  . ARG A 1 235 ? 145.624 147.280 123.484 1.00 57.45  ?  220 ARG R CA  1 
ATOM   791  C C   . ARG A 1 235 ? 144.683 146.090 123.397 1.00 57.45  ?  220 ARG R C   1 
ATOM   792  O O   . ARG A 1 235 ? 144.562 145.308 124.348 1.00 57.45  ?  220 ARG R O   1 
ATOM   793  C CB  . ARG A 1 235 ? 146.710 147.039 124.532 1.00 57.45  ?  220 ARG R CB  1 
ATOM   794  C CG  . ARG A 1 235 ? 147.740 148.141 124.651 1.00 57.45  ?  220 ARG R CG  1 
ATOM   795  C CD  . ARG A 1 235 ? 148.682 148.160 123.465 1.00 57.45  ?  220 ARG R CD  1 
ATOM   796  N NE  . ARG A 1 235 ? 149.644 149.253 123.567 1.00 57.45  ?  220 ARG R NE  1 
ATOM   797  C CZ  . ARG A 1 235 ? 150.802 149.173 124.216 1.00 57.45  ?  220 ARG R CZ  1 
ATOM   798  N NH1 . ARG A 1 235 ? 151.615 150.219 124.256 1.00 57.45  ?  220 ARG R NH1 1 
ATOM   799  N NH2 . ARG A 1 235 ? 151.144 148.050 124.832 1.00 57.45  ?  220 ARG R NH2 1 
ATOM   800  N N   . PRO A 1 236 ? 143.993 145.918 122.261 1.00 53.39  ?  221 PRO R N   1 
ATOM   801  C CA  . PRO A 1 236 ? 142.943 144.892 122.187 1.00 53.39  ?  221 PRO R CA  1 
ATOM   802  C C   . PRO A 1 236 ? 143.473 143.480 122.087 1.00 53.39  ?  221 PRO R C   1 
ATOM   803  O O   . PRO A 1 236 ? 142.704 142.532 122.291 1.00 53.39  ?  221 PRO R O   1 
ATOM   804  C CB  . PRO A 1 236 ? 142.177 145.271 120.918 1.00 53.39  ?  221 PRO R CB  1 
ATOM   805  C CG  . PRO A 1 236 ? 143.203 145.907 120.067 1.00 53.39  ?  221 PRO R CG  1 
ATOM   806  C CD  . PRO A 1 236 ? 144.126 146.650 120.990 1.00 53.39  ?  221 PRO R CD  1 
ATOM   807  N N   . LEU A 1 237 ? 144.758 143.315 121.788 1.00 55.32  ?  222 LEU R N   1 
ATOM   808  C CA  . LEU A 1 237 ? 145.361 141.993 121.705 1.00 55.32  ?  222 LEU R CA  1 
ATOM   809  C C   . LEU A 1 237 ? 145.521 141.375 123.090 1.00 55.32  ?  222 LEU R C   1 
ATOM   810  O O   . LEU A 1 237 ? 145.398 140.156 123.253 1.00 55.32  ?  222 LEU R O   1 
ATOM   811  C CB  . LEU A 1 237 ? 146.710 142.100 121.000 1.00 55.32  ?  222 LEU R CB  1 
ATOM   812  C CG  . LEU A 1 237 ? 146.635 142.686 119.588 1.00 55.32  ?  222 LEU R CG  1 
ATOM   813  C CD1 . LEU A 1 237 ? 148.029 142.947 119.047 1.00 55.32  ?  222 LEU R CD1 1 
ATOM   814  C CD2 . LEU A 1 237 ? 145.850 141.781 118.646 1.00 55.32  ?  222 LEU R CD2 1 
ATOM   815  N N   . ALA A 1 238 ? 145.801 142.205 124.094 1.00 53.99  ?  223 ALA R N   1 
ATOM   816  C CA  . ALA A 1 238 ? 145.990 141.758 125.472 1.00 53.99  ?  223 ALA R CA  1 
ATOM   817  C C   . ALA A 1 238 ? 144.847 142.284 126.333 1.00 53.99  ?  223 ALA R C   1 
ATOM   818  O O   . ALA A 1 238 ? 144.910 143.395 126.858 1.00 53.99  ?  223 ALA R O   1 
ATOM   819  C CB  . ALA A 1 238 ? 147.340 142.223 126.002 1.00 53.99  ?  223 ALA R CB  1 
ATOM   820  N N   . TYR A 1 239 ? 143.789 141.486 126.469 1.00 55.21  ?  224 TYR R N   1 
ATOM   821  C CA  . TYR A 1 239 ? 142.719 141.753 127.423 1.00 55.21  ?  224 TYR R CA  1 
ATOM   822  C C   . TYR A 1 239 ? 142.323 140.430 128.071 1.00 55.21  ?  224 TYR R C   1 
ATOM   823  O O   . TYR A 1 239 ? 141.515 140.381 129.002 1.00 55.21  ?  224 TYR R O   1 
ATOM   824  C CB  . TYR A 1 239 ? 141.533 142.437 126.728 1.00 55.21  ?  224 TYR R CB  1 
ATOM   825  C CG  . TYR A 1 239 ? 140.353 142.746 127.625 1.00 55.21  ?  224 TYR R CG  1 
ATOM   826  C CD1 . TYR A 1 239 ? 140.402 143.783 128.540 1.00 55.21  ?  224 TYR R CD1 1 
ATOM   827  C CD2 . TYR A 1 239 ? 139.198 141.976 127.568 1.00 55.21  ?  224 TYR R CD2 1 
ATOM   828  C CE1 . TYR A 1 239 ? 139.329 144.050 129.367 1.00 55.21  ?  224 TYR R CE1 1 
ATOM   829  C CE2 . TYR A 1 239 ? 138.125 142.235 128.391 1.00 55.21  ?  224 TYR R CE2 1 
ATOM   830  C CZ  . TYR A 1 239 ? 138.196 143.272 129.287 1.00 55.21  ?  224 TYR R CZ  1 
ATOM   831  O OH  . TYR A 1 239 ? 137.127 143.535 130.106 1.00 55.21  ?  224 TYR R OH  1 
ATOM   832  N N   . LYS A 1 240 ? 142.956 139.348 127.647 1.00 58.11  ?  225 LYS R N   1 
ATOM   833  C CA  . LYS A 1 240 ? 142.648 138.063 128.247 1.00 58.11  ?  225 LYS R CA  1 
ATOM   834  C C   . LYS A 1 240 ? 143.870 137.572 129.001 1.00 58.11  ?  225 LYS R C   1 
ATOM   835  O O   . LYS A 1 240 ? 143.854 136.489 129.593 1.00 58.11  ?  225 LYS R O   1 
ATOM   836  C CB  . LYS A 1 240 ? 142.213 137.059 127.180 1.00 58.11  ?  225 LYS R CB  1 
ATOM   837  N N   . ARG A 1 241 ? 144.926 138.371 128.999 1.00 59.87  ?  226 ARG R N   1 
ATOM   838  C CA  . ARG A 1 241 ? 146.157 138.006 129.683 1.00 59.87  ?  226 ARG R CA  1 
ATOM   839  C C   . ARG A 1 241 ? 146.627 139.052 130.682 1.00 59.87  ?  226 ARG R C   1 
ATOM   840  O O   . ARG A 1 241 ? 147.311 138.703 131.646 1.00 59.87  ?  226 ARG R O   1 
ATOM   841  C CB  . ARG A 1 241 ? 147.264 137.704 128.651 1.00 59.87  ?  226 ARG R CB  1 
ATOM   842  C CG  . ARG A 1 241 ? 147.628 138.851 127.742 1.00 59.87  ?  226 ARG R CG  1 
ATOM   843  C CD  . ARG A 1 241 ? 148.627 138.447 126.664 1.00 59.87  ?  226 ARG R CD  1 
ATOM   844  N NE  . ARG A 1 241 ? 149.932 138.082 127.200 1.00 59.87  ?  226 ARG R NE  1 
ATOM   845  C CZ  . ARG A 1 241 ? 150.921 137.578 126.469 1.00 59.87  ?  226 ARG R CZ  1 
ATOM   846  N NH1 . ARG A 1 241 ? 152.074 137.267 127.039 1.00 59.87  ?  226 ARG R NH1 1 
ATOM   847  N NH2 . ARG A 1 241 ? 150.770 137.407 125.164 1.00 59.87  ?  226 ARG R NH2 1 
ATOM   848  N N   . ILE A 1 242 ? 146.285 140.326 130.494 1.00 56.50  ?  227 ILE R N   1 
ATOM   849  C CA  . ILE A 1 242 ? 146.574 141.326 131.518 1.00 56.50  ?  227 ILE R CA  1 
ATOM   850  C C   . ILE A 1 242 ? 145.509 141.271 132.605 1.00 56.50  ?  227 ILE R C   1 
ATOM   851  O O   . ILE A 1 242 ? 145.814 140.987 133.766 1.00 56.50  ?  227 ILE R O   1 
ATOM   852  C CB  . ILE A 1 242 ? 146.696 142.745 130.932 1.00 56.50  ?  227 ILE R CB  1 
ATOM   853  C CG1 . ILE A 1 242 ? 147.965 142.868 130.093 1.00 56.50  ?  227 ILE R CG1 1 
ATOM   854  C CG2 . ILE A 1 242 ? 146.719 143.788 132.033 1.00 56.50  ?  227 ILE R CG2 1 
ATOM   855  C CD1 . ILE A 1 242 ? 148.084 144.185 129.373 1.00 56.50  ?  227 ILE R CD1 1 
ATOM   856  N N   . VAL A 1 243 ? 144.253 141.521 132.244 1.00 55.78  ?  228 VAL R N   1 
ATOM   857  C CA  . VAL A 1 243 ? 143.197 141.618 133.244 1.00 55.78  ?  228 VAL R CA  1 
ATOM   858  C C   . VAL A 1 243 ? 142.696 140.220 133.578 1.00 55.78  ?  228 VAL R C   1 
ATOM   859  O O   . VAL A 1 243 ? 141.837 139.672 132.878 1.00 55.78  ?  228 VAL R O   1 
ATOM   860  C CB  . VAL A 1 243 ? 142.054 142.521 132.751 1.00 55.78  ?  228 VAL R CB  1 
ATOM   861  C CG1 . VAL A 1 243 ? 140.984 142.680 133.823 1.00 55.78  ?  228 VAL R CG1 1 
ATOM   862  C CG2 . VAL A 1 243 ? 142.599 143.867 132.315 1.00 55.78  ?  228 VAL R CG2 1 
ATOM   863  N N   . THR A 1 244 ? 143.235 139.627 134.638 1.00 59.95  ?  229 THR R N   1 
ATOM   864  C CA  . THR A 1 244 ? 142.842 138.289 135.052 1.00 59.95  ?  229 THR R CA  1 
ATOM   865  C C   . THR A 1 244 ? 142.124 138.360 136.398 1.00 59.95  ?  229 THR R C   1 
ATOM   866  O O   . THR A 1 244 ? 142.051 139.414 137.031 1.00 59.95  ?  229 THR R O   1 
ATOM   867  C CB  . THR A 1 244 ? 144.060 137.373 135.117 1.00 59.95  ?  229 THR R CB  1 
ATOM   868  N N   . ARG A 1 245 ? 141.585 137.232 136.849 1.00 64.36  ?  230 ARG R N   1 
ATOM   869  C CA  . ARG A 1 245 ? 140.967 137.126 138.170 1.00 64.36  ?  230 ARG R CA  1 
ATOM   870  C C   . ARG A 1 245 ? 141.909 137.267 139.375 1.00 64.36  ?  230 ARG R C   1 
ATOM   871  O O   . ARG A 1 245 ? 141.435 137.725 140.420 1.00 64.36  ?  230 ARG R O   1 
ATOM   872  C CB  . ARG A 1 245 ? 140.193 135.810 138.287 1.00 64.36  ?  230 ARG R CB  1 
ATOM   873  C CG  . ARG A 1 245 ? 138.936 135.764 137.449 1.00 64.36  ?  230 ARG R CG  1 
ATOM   874  C CD  . ARG A 1 245 ? 138.217 134.438 137.608 1.00 64.36  ?  230 ARG R CD  1 
ATOM   875  N NE  . ARG A 1 245 ? 136.974 134.397 136.844 1.00 64.36  ?  230 ARG R NE  1 
ATOM   876  C CZ  . ARG A 1 245 ? 136.878 133.954 135.595 1.00 64.36  ?  230 ARG R CZ  1 
ATOM   877  N NH1 . ARG A 1 245 ? 135.705 133.956 134.978 1.00 64.36  ?  230 ARG R NH1 1 
ATOM   878  N NH2 . ARG A 1 245 ? 137.953 133.509 134.963 1.00 64.36  ?  230 ARG R NH2 1 
ATOM   879  N N   . PRO A 1 246 ? 143.200 136.891 139.336 1.00 61.11  ?  231 PRO R N   1 
ATOM   880  C CA  . PRO A 1 246 ? 144.092 137.296 140.436 1.00 61.11  ?  231 PRO R CA  1 
ATOM   881  C C   . PRO A 1 246 ? 144.380 138.784 140.584 1.00 61.11  ?  231 PRO R C   1 
ATOM   882  O O   . PRO A 1 246 ? 144.852 139.178 141.656 1.00 61.11  ?  231 PRO R O   1 
ATOM   883  C CB  . PRO A 1 246 ? 145.395 136.546 140.117 1.00 61.11  ?  231 PRO R CB  1 
ATOM   884  C CG  . PRO A 1 246 ? 144.960 135.349 139.432 1.00 61.11  ?  231 PRO R CG  1 
ATOM   885  C CD  . PRO A 1 246 ? 143.808 135.765 138.588 1.00 61.11  ?  231 PRO R CD  1 
ATOM   886  N N   . LYS A 1 247 ? 144.130 139.618 139.574 1.00 59.67  ?  232 LYS R N   1 
ATOM   887  C CA  . LYS A 1 247 ? 144.329 141.059 139.702 1.00 59.67  ?  232 LYS R CA  1 
ATOM   888  C C   . LYS A 1 247 ? 143.025 141.831 139.574 1.00 59.67  ?  232 LYS R C   1 
ATOM   889  O O   . LYS A 1 247 ? 143.046 143.056 139.429 1.00 59.67  ?  232 LYS R O   1 
ATOM   890  C CB  . LYS A 1 247 ? 145.341 141.577 138.681 1.00 59.67  ?  232 LYS R CB  1 
ATOM   891  C CG  . LYS A 1 247 ? 146.756 141.097 138.910 1.00 59.67  ?  232 LYS R CG  1 
ATOM   892  C CD  . LYS A 1 247 ? 147.727 141.780 137.972 1.00 59.67  ?  232 LYS R CD  1 
ATOM   893  C CE  . LYS A 1 247 ? 147.546 141.314 136.547 1.00 59.67  ?  232 LYS R CE  1 
ATOM   894  N NZ  . LYS A 1 247 ? 147.900 139.881 136.385 1.00 59.67  ?  232 LYS R NZ  1 
ATOM   895  N N   . ALA A 1 248 ? 141.891 141.139 139.616 1.00 61.13  ?  233 ALA R N   1 
ATOM   896  C CA  . ALA A 1 248 ? 140.588 141.784 139.667 1.00 61.13  ?  233 ALA R CA  1 
ATOM   897  C C   . ALA A 1 248 ? 139.777 141.315 140.865 1.00 61.13  ?  233 ALA R C   1 
ATOM   898  O O   . ALA A 1 248 ? 138.588 141.638 140.957 1.00 61.13  ?  233 ALA R O   1 
ATOM   899  C CB  . ALA A 1 248 ? 139.803 141.538 138.378 1.00 61.13  ?  233 ALA R CB  1 
ATOM   900  N N   . VAL A 1 249 ? 140.380 140.545 141.772 1.00 58.78  ?  234 VAL R N   1 
ATOM   901  C CA  . VAL A 1 249 ? 139.770 140.188 143.045 1.00 58.78  ?  234 VAL R CA  1 
ATOM   902  C C   . VAL A 1 249 ? 140.499 140.858 144.205 1.00 58.78  ?  234 VAL R C   1 
ATOM   903  O O   . VAL A 1 249 ? 139.968 140.959 145.313 1.00 58.78  ?  234 VAL R O   1 
ATOM   904  C CB  . VAL A 1 249 ? 139.713 138.651 143.238 1.00 58.78  ?  234 VAL R CB  1 
ATOM   905  C CG1 . VAL A 1 249 ? 141.054 138.083 143.677 1.00 58.78  ?  234 VAL R CG1 1 
ATOM   906  C CG2 . VAL A 1 249 ? 138.584 138.243 144.183 1.00 58.78  ?  234 VAL R CG2 1 
ATOM   907  N N   . VAL A 1 250 ? 141.724 141.333 143.964 1.00 58.10  ?  235 VAL R N   1 
ATOM   908  C CA  . VAL A 1 250 ? 142.413 142.122 144.978 1.00 58.10  ?  235 VAL R CA  1 
ATOM   909  C C   . VAL A 1 250 ? 142.163 143.602 144.735 1.00 58.10  ?  235 VAL R C   1 
ATOM   910  O O   . VAL A 1 250 ? 142.373 144.438 145.620 1.00 58.10  ?  235 VAL R O   1 
ATOM   911  C CB  . VAL A 1 250 ? 143.919 141.785 144.995 1.00 58.10  ?  235 VAL R CB  1 
ATOM   912  C CG1 . VAL A 1 250 ? 144.646 142.443 143.840 1.00 58.10  ?  235 VAL R CG1 1 
ATOM   913  C CG2 . VAL A 1 250 ? 144.556 142.139 146.333 1.00 58.10  ?  235 VAL R CG2 1 
ATOM   914  N N   . ALA A 1 251 ? 141.671 143.945 143.540 1.00 59.15  ?  236 ALA R N   1 
ATOM   915  C CA  . ALA A 1 251 ? 141.582 145.345 143.134 1.00 59.15  ?  236 ALA R CA  1 
ATOM   916  C C   . ALA A 1 251 ? 140.447 146.064 143.847 1.00 59.15  ?  236 ALA R C   1 
ATOM   917  O O   . ALA A 1 251 ? 140.571 147.243 144.189 1.00 59.15  ?  236 ALA R O   1 
ATOM   918  C CB  . ALA A 1 251 ? 141.413 145.450 141.620 1.00 59.15  ?  236 ALA R CB  1 
ATOM   919  N N   . PHE A 1 252 ? 139.323 145.382 144.067 1.00 60.19  ?  237 PHE R N   1 
ATOM   920  C CA  . PHE A 1 252 ? 138.276 146.015 144.858 1.00 60.19  ?  237 PHE R CA  1 
ATOM   921  C C   . PHE A 1 252 ? 138.509 145.854 146.356 1.00 60.19  ?  237 PHE R C   1 
ATOM   922  O O   . PHE A 1 252 ? 137.723 146.381 147.148 1.00 60.19  ?  237 PHE R O   1 
ATOM   923  C CB  . PHE A 1 252 ? 136.890 145.491 144.446 1.00 60.19  ?  237 PHE R CB  1 
ATOM   924  C CG  . PHE A 1 252 ? 136.616 144.064 144.831 1.00 60.19  ?  237 PHE R CG  1 
ATOM   925  C CD1 . PHE A 1 252 ? 137.026 143.021 144.019 1.00 60.19  ?  237 PHE R CD1 1 
ATOM   926  C CD2 . PHE A 1 252 ? 135.881 143.770 145.973 1.00 60.19  ?  237 PHE R CD2 1 
ATOM   927  C CE1 . PHE A 1 252 ? 136.752 141.707 144.363 1.00 60.19  ?  237 PHE R CE1 1 
ATOM   928  C CE2 . PHE A 1 252 ? 135.607 142.461 146.323 1.00 60.19  ?  237 PHE R CE2 1 
ATOM   929  C CZ  . PHE A 1 252 ? 136.043 141.429 145.516 1.00 60.19  ?  237 PHE R CZ  1 
ATOM   930  N N   . CYS A 1 253 ? 139.562 145.150 146.765 1.00 60.02  ?  238 CYS R N   1 
ATOM   931  C CA  . CYS A 1 253 ? 139.953 145.118 148.167 1.00 60.02  ?  238 CYS R CA  1 
ATOM   932  C C   . CYS A 1 253 ? 140.764 146.359 148.514 1.00 60.02  ?  238 CYS R C   1 
ATOM   933  O O   . CYS A 1 253 ? 140.662 146.880 149.627 1.00 60.02  ?  238 CYS R O   1 
ATOM   934  C CB  . CYS A 1 253 ? 140.746 143.852 148.482 1.00 60.02  ?  238 CYS R CB  1 
ATOM   935  S SG  . CYS A 1 253 ? 139.774 142.337 148.446 1.00 60.02  ?  238 CYS R SG  1 
ATOM   936  N N   . LEU A 1 254 ? 141.588 146.829 147.580 1.00 62.79  ?  239 LEU R N   1 
ATOM   937  C CA  . LEU A 1 254 ? 142.375 148.042 147.778 1.00 62.79  ?  239 LEU R CA  1 
ATOM   938  C C   . LEU A 1 254 ? 141.623 149.331 147.467 1.00 62.79  ?  239 LEU R C   1 
ATOM   939  O O   . LEU A 1 254 ? 142.255 150.375 147.292 1.00 62.79  ?  239 LEU R O   1 
ATOM   940  C CB  . LEU A 1 254 ? 143.664 147.990 146.957 1.00 62.79  ?  239 LEU R CB  1 
ATOM   941  C CG  . LEU A 1 254 ? 144.916 147.481 147.675 1.00 62.79  ?  239 LEU R CG  1 
ATOM   942  C CD1 . LEU A 1 254 ? 144.801 146.044 148.125 1.00 62.79  ?  239 LEU R CD1 1 
ATOM   943  C CD2 . LEU A 1 254 ? 146.107 147.635 146.756 1.00 62.79  ?  239 LEU R CD2 1 
ATOM   944  N N   . MET A 1 255 ? 140.295 149.290 147.354 1.00 63.01  ?  240 MET R N   1 
ATOM   945  C CA  . MET A 1 255 ? 139.495 150.511 147.374 1.00 63.01  ?  240 MET R CA  1 
ATOM   946  C C   . MET A 1 255 ? 138.666 150.580 148.652 1.00 63.01  ?  240 MET R C   1 
ATOM   947  O O   . MET A 1 255 ? 138.464 151.668 149.190 1.00 63.01  ?  240 MET R O   1 
ATOM   948  C CB  . MET A 1 255 ? 138.613 150.653 146.129 1.00 63.01  ?  240 MET R CB  1 
ATOM   949  C CG  . MET A 1 255 ? 137.509 149.639 145.975 1.00 63.01  ?  240 MET R CG  1 
ATOM   950  S SD  . MET A 1 255 ? 136.426 150.077 144.619 1.00 63.01  ?  240 MET R SD  1 
ATOM   951  C CE  . MET A 1 255 ? 135.605 151.494 145.337 1.00 63.01  ?  240 MET R CE  1 
ATOM   952  N N   . TRP A 1 256 ? 138.196 149.446 149.171 1.00 60.61  ?  241 TRP R N   1 
ATOM   953  C CA  . TRP A 1 256 ? 137.416 149.434 150.403 1.00 60.61  ?  241 TRP R CA  1 
ATOM   954  C C   . TRP A 1 256 ? 138.325 149.447 151.626 1.00 60.61  ?  241 TRP R C   1 
ATOM   955  O O   . TRP A 1 256 ? 137.846 149.510 152.761 1.00 60.61  ?  241 TRP R O   1 
ATOM   956  C CB  . TRP A 1 256 ? 136.489 148.218 150.435 1.00 60.61  ?  241 TRP R CB  1 
ATOM   957  C CG  . TRP A 1 256 ? 135.289 148.311 149.538 1.00 60.61  ?  241 TRP R CG  1 
ATOM   958  C CD1 . TRP A 1 256 ? 135.222 147.960 148.226 1.00 60.61  ?  241 TRP R CD1 1 
ATOM   959  C CD2 . TRP A 1 256 ? 133.962 148.704 149.912 1.00 60.61  ?  241 TRP R CD2 1 
ATOM   960  N NE1 . TRP A 1 256 ? 133.951 148.148 147.746 1.00 60.61  ?  241 TRP R NE1 1 
ATOM   961  C CE2 . TRP A 1 256 ? 133.156 148.599 148.765 1.00 60.61  ?  241 TRP R CE2 1 
ATOM   962  C CE3 . TRP A 1 256 ? 133.381 149.148 151.103 1.00 60.61  ?  241 TRP R CE3 1 
ATOM   963  C CZ2 . TRP A 1 256 ? 131.803 148.924 148.771 1.00 60.61  ?  241 TRP R CZ2 1 
ATOM   964  C CZ3 . TRP A 1 256 ? 132.033 149.470 151.105 1.00 60.61  ?  241 TRP R CZ3 1 
ATOM   965  C CH2 . TRP A 1 256 ? 131.262 149.356 149.948 1.00 60.61  ?  241 TRP R CH2 1 
ATOM   966  N N   . THR A 1 257 ? 139.638 149.382 151.409 1.00 63.99  ?  242 THR R N   1 
ATOM   967  C CA  . THR A 1 257 ? 140.611 149.533 152.481 1.00 63.99  ?  242 THR R CA  1 
ATOM   968  C C   . THR A 1 257 ? 141.343 150.867 152.403 1.00 63.99  ?  242 THR R C   1 
ATOM   969  O O   . THR A 1 257 ? 142.278 151.096 153.178 1.00 63.99  ?  242 THR R O   1 
ATOM   970  C CB  . THR A 1 257 ? 141.616 148.379 152.466 1.00 63.99  ?  242 THR R CB  1 
ATOM   971  N N   . ILE A 1 258 ? 140.959 151.741 151.472 1.00 64.48  ?  243 ILE R N   1 
ATOM   972  C CA  . ILE A 1 258 ? 141.402 153.127 151.428 1.00 64.48  ?  243 ILE R CA  1 
ATOM   973  C C   . ILE A 1 258 ? 140.235 154.087 151.645 1.00 64.48  ?  243 ILE R C   1 
ATOM   974  O O   . ILE A 1 258 ? 140.412 155.166 152.212 1.00 64.48  ?  243 ILE R O   1 
ATOM   975  C CB  . ILE A 1 258 ? 142.153 153.421 150.109 1.00 64.48  ?  243 ILE R CB  1 
ATOM   976  C CG1 . ILE A 1 258 ? 143.392 152.537 150.008 1.00 64.48  ?  243 ILE R CG1 1 
ATOM   977  C CG2 . ILE A 1 258 ? 142.635 154.863 149.989 1.00 64.48  ?  243 ILE R CG2 1 
ATOM   978  C CD1 . ILE A 1 258 ? 144.130 152.668 148.693 1.00 64.48  ?  243 ILE R CD1 1 
ATOM   979  N N   . ALA A 1 259 ? 139.015 153.661 151.319 1.00 65.51  ?  244 ALA R N   1 
ATOM   980  C CA  . ALA A 1 259 ? 137.829 154.476 151.547 1.00 65.51  ?  244 ALA R CA  1 
ATOM   981  C C   . ALA A 1 259 ? 137.329 154.378 152.984 1.00 65.51  ?  244 ALA R C   1 
ATOM   982  O O   . ALA A 1 259 ? 136.414 155.111 153.366 1.00 65.51  ?  244 ALA R O   1 
ATOM   983  C CB  . ALA A 1 259 ? 136.714 154.085 150.580 1.00 65.51  ?  244 ALA R CB  1 
ATOM   984  N N   . ILE A 1 260 ? 137.896 153.477 153.789 1.00 62.50  ?  245 ILE R N   1 
ATOM   985  C CA  . ILE A 1 260 ? 137.577 153.398 155.211 1.00 62.50  ?  245 ILE R CA  1 
ATOM   986  C C   . ILE A 1 260 ? 138.912 153.580 155.935 1.00 62.50  ?  245 ILE R C   1 
ATOM   987  O O   . ILE A 1 260 ? 139.131 153.080 157.042 1.00 62.50  ?  245 ILE R O   1 
ATOM   988  C CB  . ILE A 1 260 ? 136.860 152.077 155.569 1.00 62.50  ?  245 ILE R CB  1 
ATOM   989  C CG1 . ILE A 1 260 ? 135.726 151.793 154.587 1.00 62.50  ?  245 ILE R CG1 1 
ATOM   990  C CG2 . ILE A 1 260 ? 136.108 152.191 156.890 1.00 62.50  ?  245 ILE R CG2 1 
ATOM   991  C CD1 . ILE A 1 260 ? 135.101 150.424 154.733 1.00 62.50  ?  245 ILE R CD1 1 
ATOM   992  N N   . VAL A 1 261 ? 139.835 154.283 155.289 1.00 62.64  ?  246 VAL R N   1 
ATOM   993  C CA  . VAL A 1 261 ? 141.060 154.731 155.941 1.00 62.64  ?  246 VAL R CA  1 
ATOM   994  C C   . VAL A 1 261 ? 141.211 156.218 155.662 1.00 62.64  ?  246 VAL R C   1 
ATOM   995  O O   . VAL A 1 261 ? 142.225 156.833 156.007 1.00 62.64  ?  246 VAL R O   1 
ATOM   996  C CB  . VAL A 1 261 ? 142.286 153.943 155.455 1.00 62.64  ?  246 VAL R CB  1 
ATOM   997  N N   . ILE A 1 262 ? 140.198 156.792 155.016 1.00 61.96  ?  247 ILE R N   1 
ATOM   998  C CA  . ILE A 1 262 ? 140.100 158.225 154.769 1.00 61.96  ?  247 ILE R CA  1 
ATOM   999  C C   . ILE A 1 262 ? 138.703 158.681 155.165 1.00 61.96  ?  247 ILE R C   1 
ATOM   1000 O O   . ILE A 1 262 ? 138.260 159.766 154.776 1.00 61.96  ?  247 ILE R O   1 
ATOM   1001 C CB  . ILE A 1 262 ? 140.402 158.569 153.300 1.00 61.96  ?  247 ILE R CB  1 
ATOM   1002 N N   . ALA A 1 263 ? 137.994 157.845 155.924 1.00 61.76  ?  248 ALA R N   1 
ATOM   1003 C CA  . ALA A 1 263 ? 136.664 158.186 156.415 1.00 61.76  ?  248 ALA R CA  1 
ATOM   1004 C C   . ALA A 1 263 ? 136.535 157.849 157.895 1.00 61.76  ?  248 ALA R C   1 
ATOM   1005 O O   . ALA A 1 263 ? 135.471 158.036 158.491 1.00 61.76  ?  248 ALA R O   1 
ATOM   1006 C CB  . ALA A 1 263 ? 135.590 157.462 155.609 1.00 61.76  ?  248 ALA R CB  1 
ATOM   1007 N N   . VAL A 1 264 ? 137.614 157.341 158.488 1.00 58.10  ?  249 VAL R N   1 
ATOM   1008 C CA  . VAL A 1 264 ? 137.730 157.159 159.931 1.00 58.10  ?  249 VAL R CA  1 
ATOM   1009 C C   . VAL A 1 264 ? 138.826 158.139 160.339 1.00 58.10  ?  249 VAL R C   1 
ATOM   1010 O O   . VAL A 1 264 ? 139.041 158.416 161.523 1.00 58.10  ?  249 VAL R O   1 
ATOM   1011 C CB  . VAL A 1 264 ? 138.044 155.688 160.282 1.00 58.10  ?  249 VAL R CB  1 
ATOM   1012 C CG1 . VAL A 1 264 ? 138.054 155.419 161.786 1.00 58.10  ?  249 VAL R CG1 1 
ATOM   1013 C CG2 . VAL A 1 264 ? 137.042 154.769 159.615 1.00 58.10  ?  249 VAL R CG2 1 
ATOM   1014 N N   . LEU A 1 265 ? 139.431 158.772 159.331 1.00 55.92  ?  250 LEU R N   1 
ATOM   1015 C CA  . LEU A 1 265 ? 140.521 159.749 159.376 1.00 55.92  ?  250 LEU R CA  1 
ATOM   1016 C C   . LEU A 1 265 ? 140.352 160.961 160.308 1.00 55.92  ?  250 LEU R C   1 
ATOM   1017 O O   . LEU A 1 265 ? 141.376 161.526 160.709 1.00 55.92  ?  250 LEU R O   1 
ATOM   1018 C CB  . LEU A 1 265 ? 140.795 160.220 157.940 1.00 55.92  ?  250 LEU R CB  1 
ATOM   1019 C CG  . LEU A 1 265 ? 142.102 160.905 157.503 1.00 55.92  ?  250 LEU R CG  1 
ATOM   1020 C CD1 . LEU A 1 265 ? 142.158 162.422 157.684 1.00 55.92  ?  250 LEU R CD1 1 
ATOM   1021 C CD2 . LEU A 1 265 ? 143.263 160.257 158.233 1.00 55.92  ?  250 LEU R CD2 1 
ATOM   1022 N N   . PRO A 1 266 ? 139.123 161.396 160.744 1.00 57.58  ?  251 PRO R N   1 
ATOM   1023 C CA  . PRO A 1 266 ? 139.073 162.440 161.787 1.00 57.58  ?  251 PRO R CA  1 
ATOM   1024 C C   . PRO A 1 266 ? 139.560 162.096 163.196 1.00 57.58  ?  251 PRO R C   1 
ATOM   1025 O O   . PRO A 1 266 ? 139.038 162.690 164.144 1.00 57.58  ?  251 PRO R O   1 
ATOM   1026 C CB  . PRO A 1 266 ? 137.587 162.814 161.827 1.00 57.58  ?  251 PRO R CB  1 
ATOM   1027 C CG  . PRO A 1 266 ? 137.149 162.640 160.483 1.00 57.58  ?  251 PRO R CG  1 
ATOM   1028 C CD  . PRO A 1 266 ? 137.862 161.437 159.969 1.00 57.58  ?  251 PRO R CD  1 
ATOM   1029 N N   . LEU A 1 267 ? 140.489 161.136 163.366 1.00 56.99  ?  252 LEU R N   1 
ATOM   1030 C CA  . LEU A 1 267 ? 141.104 160.753 164.644 1.00 56.99  ?  252 LEU R CA  1 
ATOM   1031 C C   . LEU A 1 267 ? 141.572 161.910 165.525 1.00 56.99  ?  252 LEU R C   1 
ATOM   1032 O O   . LEU A 1 267 ? 141.645 161.733 166.744 1.00 56.99  ?  252 LEU R O   1 
ATOM   1033 C CB  . LEU A 1 267 ? 142.330 159.856 164.426 1.00 56.99  ?  252 LEU R CB  1 
ATOM   1034 C CG  . LEU A 1 267 ? 142.315 158.371 164.058 1.00 56.99  ?  252 LEU R CG  1 
ATOM   1035 C CD1 . LEU A 1 267 ? 142.122 158.171 162.580 1.00 56.99  ?  252 LEU R CD1 1 
ATOM   1036 C CD2 . LEU A 1 267 ? 143.598 157.708 164.504 1.00 56.99  ?  252 LEU R CD2 1 
ATOM   1037 N N   . LEU A 1 268 ? 141.941 163.042 164.904 1.00 57.66  ?  253 LEU R N   1 
ATOM   1038 C CA  . LEU A 1 268 ? 142.218 164.380 165.483 1.00 57.66  ?  253 LEU R CA  1 
ATOM   1039 C C   . LEU A 1 268 ? 142.205 164.597 167.002 1.00 57.66  ?  253 LEU R C   1 
ATOM   1040 O O   . LEU A 1 268 ? 143.055 164.075 167.723 1.00 57.66  ?  253 LEU R O   1 
ATOM   1041 C CB  . LEU A 1 268 ? 141.230 165.392 164.877 1.00 57.66  ?  253 LEU R CB  1 
ATOM   1042 C CG  . LEU A 1 268 ? 141.520 166.130 163.561 1.00 57.66  ?  253 LEU R CG  1 
ATOM   1043 C CD1 . LEU A 1 268 ? 141.445 165.234 162.345 1.00 57.66  ?  253 LEU R CD1 1 
ATOM   1044 C CD2 . LEU A 1 268 ? 140.578 167.322 163.396 1.00 57.66  ?  253 LEU R CD2 1 
ATOM   1045 N N   . ASP A 1 281 ? 129.824 175.465 158.178 1.00 69.10  ?  266 ASP R N   1 
ATOM   1046 C CA  . ASP A 1 281 ? 128.613 176.200 157.837 1.00 69.10  ?  266 ASP R CA  1 
ATOM   1047 C C   . ASP A 1 281 ? 127.418 175.281 157.619 1.00 69.10  ?  266 ASP R C   1 
ATOM   1048 O O   . ASP A 1 281 ? 126.294 175.632 157.964 1.00 69.10  ?  266 ASP R O   1 
ATOM   1049 C CB  . ASP A 1 281 ? 128.839 177.056 156.592 1.00 69.10  ?  266 ASP R CB  1 
ATOM   1050 C CG  . ASP A 1 281 ? 129.677 178.283 156.874 1.00 69.10  ?  266 ASP R CG  1 
ATOM   1051 O OD1 . ASP A 1 281 ? 129.596 178.806 158.001 1.00 69.10  ?  266 ASP R OD1 1 
ATOM   1052 O OD2 . ASP A 1 281 ? 130.419 178.724 155.972 1.00 69.10  -1 266 ASP R OD2 1 
ATOM   1053 N N   . ILE A 1 282 ? 127.651 174.107 157.035 1.00 68.58  ?  267 ILE R N   1 
ATOM   1054 C CA  . ILE A 1 282 ? 126.565 173.173 156.756 1.00 68.58  ?  267 ILE R CA  1 
ATOM   1055 C C   . ILE A 1 282 ? 126.851 171.810 157.377 1.00 68.58  ?  267 ILE R C   1 
ATOM   1056 O O   . ILE A 1 282 ? 125.934 171.010 157.586 1.00 68.58  ?  267 ILE R O   1 
ATOM   1057 C CB  . ILE A 1 282 ? 126.317 173.061 155.242 1.00 68.58  ?  267 ILE R CB  1 
ATOM   1058 C CG1 . ILE A 1 282 ? 127.616 172.743 154.509 1.00 68.58  ?  267 ILE R CG1 1 
ATOM   1059 C CG2 . ILE A 1 282 ? 125.693 174.332 154.697 1.00 68.58  ?  267 ILE R CG2 1 
ATOM   1060 C CD1 . ILE A 1 282 ? 127.420 172.483 153.041 1.00 68.58  ?  267 ILE R CD1 1 
ATOM   1061 N N   . PHE A 1 283 ? 128.117 171.539 157.681 1.00 66.90  ?  268 PHE R N   1 
ATOM   1062 C CA  . PHE A 1 283 ? 128.530 170.310 158.355 1.00 66.90  ?  268 PHE R CA  1 
ATOM   1063 C C   . PHE A 1 283 ? 129.036 170.671 159.744 1.00 66.90  ?  268 PHE R C   1 
ATOM   1064 O O   . PHE A 1 283 ? 130.036 171.394 159.863 1.00 66.90  ?  268 PHE R O   1 
ATOM   1065 C CB  . PHE A 1 283 ? 129.618 169.595 157.551 1.00 66.90  ?  268 PHE R CB  1 
ATOM   1066 C CG  . PHE A 1 283 ? 129.126 168.979 156.276 1.00 66.90  ?  268 PHE R CG  1 
ATOM   1067 C CD1 . PHE A 1 283 ? 127.789 168.674 156.107 1.00 66.90  ?  268 PHE R CD1 1 
ATOM   1068 C CD2 . PHE A 1 283 ? 130.000 168.733 155.234 1.00 66.90  ?  268 PHE R CD2 1 
ATOM   1069 C CE1 . PHE A 1 283 ? 127.338 168.112 154.933 1.00 66.90  ?  268 PHE R CE1 1 
ATOM   1070 C CE2 . PHE A 1 283 ? 129.554 168.176 154.057 1.00 66.90  ?  268 PHE R CE2 1 
ATOM   1071 C CZ  . PHE A 1 283 ? 128.222 167.866 153.907 1.00 66.90  ?  268 PHE R CZ  1 
ATOM   1072 N N   . PRO A 1 284 ? 128.369 170.221 160.821 1.00 65.11  ?  269 PRO R N   1 
ATOM   1073 C CA  . PRO A 1 284 ? 128.605 170.790 162.160 1.00 65.11  ?  269 PRO R CA  1 
ATOM   1074 C C   . PRO A 1 284 ? 130.001 170.643 162.761 1.00 65.11  ?  269 PRO R C   1 
ATOM   1075 O O   . PRO A 1 284 ? 130.662 171.653 163.019 1.00 65.11  ?  269 PRO R O   1 
ATOM   1076 C CB  . PRO A 1 284 ? 127.579 170.047 163.023 1.00 65.11  ?  269 PRO R CB  1 
ATOM   1077 C CG  . PRO A 1 284 ? 126.536 169.602 162.074 1.00 65.11  ?  269 PRO R CG  1 
ATOM   1078 C CD  . PRO A 1 284 ? 127.255 169.263 160.820 1.00 65.11  ?  269 PRO R CD  1 
ATOM   1079 N N   . HIS A 1 285 ? 130.467 169.422 162.999 1.00 64.29  ?  270 HIS R N   1 
ATOM   1080 C CA  . HIS A 1 285 ? 131.768 169.217 163.639 1.00 64.29  ?  270 HIS R CA  1 
ATOM   1081 C C   . HIS A 1 285 ? 132.837 168.858 162.608 1.00 64.29  ?  270 HIS R C   1 
ATOM   1082 O O   . HIS A 1 285 ? 133.515 167.842 162.719 1.00 64.29  ?  270 HIS R O   1 
ATOM   1083 C CB  . HIS A 1 285 ? 131.665 168.139 164.712 1.00 64.29  ?  270 HIS R CB  1 
ATOM   1084 C CG  . HIS A 1 285 ? 130.716 168.469 165.823 1.00 64.29  ?  270 HIS R CG  1 
ATOM   1085 N ND1 . HIS A 1 285 ? 129.392 168.089 165.807 1.00 64.29  ?  270 HIS R ND1 1 
ATOM   1086 C CD2 . HIS A 1 285 ? 130.901 169.141 166.983 1.00 64.29  ?  270 HIS R CD2 1 
ATOM   1087 C CE1 . HIS A 1 285 ? 128.801 168.512 166.910 1.00 64.29  ?  270 HIS R CE1 1 
ATOM   1088 N NE2 . HIS A 1 285 ? 129.694 169.154 167.640 1.00 64.29  ?  270 HIS R NE2 1 
ATOM   1089 N N   . ILE A 1 286 ? 132.992 169.703 161.593 1.00 64.24  ?  271 ILE R N   1 
ATOM   1090 C CA  . ILE A 1 286 ? 133.993 169.495 160.553 1.00 64.24  ?  271 ILE R CA  1 
ATOM   1091 C C   . ILE A 1 286 ? 134.686 170.822 160.268 1.00 64.24  ?  271 ILE R C   1 
ATOM   1092 O O   . ILE A 1 286 ? 134.045 171.845 160.014 1.00 64.24  ?  271 ILE R O   1 
ATOM   1093 C CB  . ILE A 1 286 ? 133.390 168.905 159.255 1.00 64.24  ?  271 ILE R CB  1 
ATOM   1094 C CG1 . ILE A 1 286 ? 132.883 167.480 159.459 1.00 64.24  ?  271 ILE R CG1 1 
ATOM   1095 C CG2 . ILE A 1 286 ? 134.403 168.896 158.133 1.00 64.24  ?  271 ILE R CG2 1 
ATOM   1096 C CD1 . ILE A 1 286 ? 132.160 166.937 158.265 1.00 64.24  ?  271 ILE R CD1 1 
ATOM   1097 N N   . ASP A 1 287 ? 136.016 170.801 160.312 1.00 61.35  ?  272 ASP R N   1 
ATOM   1098 C CA  . ASP A 1 287 ? 136.831 171.974 160.029 1.00 61.35  ?  272 ASP R CA  1 
ATOM   1099 C C   . ASP A 1 287 ? 137.050 172.111 158.529 1.00 61.35  ?  272 ASP R C   1 
ATOM   1100 O O   . ASP A 1 287 ? 136.992 171.119 157.796 1.00 61.35  ?  272 ASP R O   1 
ATOM   1101 C CB  . ASP A 1 287 ? 138.164 171.905 160.772 1.00 61.35  ?  272 ASP R CB  1 
ATOM   1102 C CG  . ASP A 1 287 ? 138.877 170.596 160.566 1.00 61.35  ?  272 ASP R CG  1 
ATOM   1103 O OD1 . ASP A 1 287 ? 138.297 169.689 159.934 1.00 61.35  ?  272 ASP R OD1 1 
ATOM   1104 O OD2 . ASP A 1 287 ? 140.018 170.467 161.053 1.00 61.35  -1 272 ASP R OD2 1 
ATOM   1105 N N   . GLU A 1 288 ? 137.305 173.344 158.084 1.00 62.87  ?  273 GLU R N   1 
ATOM   1106 C CA  . GLU A 1 288 ? 137.312 173.658 156.657 1.00 62.87  ?  273 GLU R CA  1 
ATOM   1107 C C   . GLU A 1 288 ? 138.534 173.083 155.947 1.00 62.87  ?  273 GLU R C   1 
ATOM   1108 O O   . GLU A 1 288 ? 138.537 172.933 154.722 1.00 62.87  ?  273 GLU R O   1 
ATOM   1109 C CB  . GLU A 1 288 ? 137.240 175.172 156.459 1.00 62.87  ?  273 GLU R CB  1 
ATOM   1110 N N   . THR A 1 289 ? 139.582 172.746 156.701 1.00 59.75  ?  274 THR R N   1 
ATOM   1111 C CA  . THR A 1 289 ? 140.797 172.187 156.115 1.00 59.75  ?  274 THR R CA  1 
ATOM   1112 C C   . THR A 1 289 ? 140.652 170.710 155.757 1.00 59.75  ?  274 THR R C   1 
ATOM   1113 O O   . THR A 1 289 ? 141.599 170.097 155.258 1.00 59.75  ?  274 THR R O   1 
ATOM   1114 C CB  . THR A 1 289 ? 141.980 172.368 157.068 1.00 59.75  ?  274 THR R CB  1 
ATOM   1115 N N   . TYR A 1 290 ? 139.477 170.129 156.006 1.00 58.81  ?  275 TYR R N   1 
ATOM   1116 C CA  . TYR A 1 290 ? 139.176 168.762 155.604 1.00 58.81  ?  275 TYR R CA  1 
ATOM   1117 C C   . TYR A 1 290 ? 138.254 168.689 154.397 1.00 58.81  ?  275 TYR R C   1 
ATOM   1118 O O   . TYR A 1 290 ? 138.278 167.676 153.694 1.00 58.81  ?  275 TYR R O   1 
ATOM   1119 C CB  . TYR A 1 290 ? 138.552 167.997 156.782 1.00 58.81  ?  275 TYR R CB  1 
ATOM   1120 C CG  . TYR A 1 290 ? 138.188 166.553 156.521 1.00 58.81  ?  275 TYR R CG  1 
ATOM   1121 C CD1 . TYR A 1 290 ? 139.162 165.573 156.427 1.00 58.81  ?  275 TYR R CD1 1 
ATOM   1122 C CD2 . TYR A 1 290 ? 136.863 166.171 156.392 1.00 58.81  ?  275 TYR R CD2 1 
ATOM   1123 C CE1 . TYR A 1 290 ? 138.823 164.257 156.195 1.00 58.81  ?  275 TYR R CE1 1 
ATOM   1124 C CE2 . TYR A 1 290 ? 136.516 164.861 156.162 1.00 58.81  ?  275 TYR R CE2 1 
ATOM   1125 C CZ  . TYR A 1 290 ? 137.498 163.911 156.067 1.00 58.81  ?  275 TYR R CZ  1 
ATOM   1126 O OH  . TYR A 1 290 ? 137.144 162.607 155.839 1.00 58.81  ?  275 TYR R OH  1 
ATOM   1127 N N   . LEU A 1 291 ? 137.480 169.733 154.099 1.00 62.47  ?  276 LEU R N   1 
ATOM   1128 C CA  . LEU A 1 291 ? 136.699 169.801 152.872 1.00 62.47  ?  276 LEU R CA  1 
ATOM   1129 C C   . LEU A 1 291 ? 137.521 170.273 151.678 1.00 62.47  ?  276 LEU R C   1 
ATOM   1130 O O   . LEU A 1 291 ? 136.983 170.390 150.574 1.00 62.47  ?  276 LEU R O   1 
ATOM   1131 C CB  . LEU A 1 291 ? 135.489 170.714 153.059 1.00 62.47  ?  276 LEU R CB  1 
ATOM   1132 C CG  . LEU A 1 291 ? 134.413 170.189 153.998 1.00 62.47  ?  276 LEU R CG  1 
ATOM   1133 C CD1 . LEU A 1 291 ? 133.314 171.215 154.180 1.00 62.47  ?  276 LEU R CD1 1 
ATOM   1134 C CD2 . LEU A 1 291 ? 133.864 168.907 153.435 1.00 62.47  ?  276 LEU R CD2 1 
ATOM   1135 N N   . MET A 1 292 ? 138.809 170.552 151.876 1.00 64.61  ?  277 MET R N   1 
ATOM   1136 C CA  . MET A 1 292 ? 139.744 170.738 150.775 1.00 64.61  ?  277 MET R CA  1 
ATOM   1137 C C   . MET A 1 292 ? 140.582 169.485 150.566 1.00 64.61  ?  277 MET R C   1 
ATOM   1138 O O   . MET A 1 292 ? 141.588 169.521 149.853 1.00 64.61  ?  277 MET R O   1 
ATOM   1139 C CB  . MET A 1 292 ? 140.643 171.950 151.021 1.00 64.61  ?  277 MET R CB  1 
ATOM   1140 N N   . PHE A 1 293 ? 140.176 168.375 151.179 1.00 62.98  ?  278 PHE R N   1 
ATOM   1141 C CA  . PHE A 1 293 ? 140.846 167.094 151.009 1.00 62.98  ?  278 PHE R CA  1 
ATOM   1142 C C   . PHE A 1 293 ? 139.916 166.117 150.311 1.00 62.98  ?  278 PHE R C   1 
ATOM   1143 O O   . PHE A 1 293 ? 140.344 165.384 149.417 1.00 62.98  ?  278 PHE R O   1 
ATOM   1144 C CB  . PHE A 1 293 ? 141.297 166.531 152.358 1.00 62.98  ?  278 PHE R CB  1 
ATOM   1145 C CG  . PHE A 1 293 ? 141.988 165.198 152.263 1.00 62.98  ?  278 PHE R CG  1 
ATOM   1146 C CD1 . PHE A 1 293 ? 143.298 165.111 151.831 1.00 62.98  ?  278 PHE R CD1 1 
ATOM   1147 C CD2 . PHE A 1 293 ? 141.323 164.032 152.609 1.00 62.98  ?  278 PHE R CD2 1 
ATOM   1148 C CE1 . PHE A 1 293 ? 143.932 163.886 151.745 1.00 62.98  ?  278 PHE R CE1 1 
ATOM   1149 C CE2 . PHE A 1 293 ? 141.949 162.808 152.522 1.00 62.98  ?  278 PHE R CE2 1 
ATOM   1150 C CZ  . PHE A 1 293 ? 143.254 162.735 152.092 1.00 62.98  ?  278 PHE R CZ  1 
ATOM   1151 N N   . TRP A 1 294 ? 138.646 166.086 150.716 1.00 67.44  ?  279 TRP R N   1 
ATOM   1152 C CA  . TRP A 1 294 ? 137.716 165.160 150.086 1.00 67.44  ?  279 TRP R CA  1 
ATOM   1153 C C   . TRP A 1 294 ? 137.321 165.607 148.688 1.00 67.44  ?  279 TRP R C   1 
ATOM   1154 O O   . TRP A 1 294 ? 137.148 164.761 147.807 1.00 67.44  ?  279 TRP R O   1 
ATOM   1155 C CB  . TRP A 1 294 ? 136.456 164.997 150.921 1.00 67.44  ?  279 TRP R CB  1 
ATOM   1156 C CG  . TRP A 1 294 ? 135.564 163.954 150.364 1.00 67.44  ?  279 TRP R CG  1 
ATOM   1157 C CD1 . TRP A 1 294 ? 135.747 162.609 150.426 1.00 67.44  ?  279 TRP R CD1 1 
ATOM   1158 C CD2 . TRP A 1 294 ? 134.384 164.163 149.582 1.00 67.44  ?  279 TRP R CD2 1 
ATOM   1159 N NE1 . TRP A 1 294 ? 134.731 161.962 149.771 1.00 67.44  ?  279 TRP R NE1 1 
ATOM   1160 C CE2 . TRP A 1 294 ? 133.883 162.896 149.238 1.00 67.44  ?  279 TRP R CE2 1 
ATOM   1161 C CE3 . TRP A 1 294 ? 133.693 165.300 149.155 1.00 67.44  ?  279 TRP R CE3 1 
ATOM   1162 C CZ2 . TRP A 1 294 ? 132.723 162.732 148.487 1.00 67.44  ?  279 TRP R CZ2 1 
ATOM   1163 C CZ3 . TRP A 1 294 ? 132.542 165.135 148.410 1.00 67.44  ?  279 TRP R CZ3 1 
ATOM   1164 C CH2 . TRP A 1 294 ? 132.069 163.861 148.084 1.00 67.44  ?  279 TRP R CH2 1 
ATOM   1165 N N   . ILE A 1 295 ? 137.176 166.913 148.464 1.00 65.77  ?  280 ILE R N   1 
ATOM   1166 C CA  . ILE A 1 295 ? 136.855 167.415 147.133 1.00 65.77  ?  280 ILE R CA  1 
ATOM   1167 C C   . ILE A 1 295 ? 138.039 167.287 146.179 1.00 65.77  ?  280 ILE R C   1 
ATOM   1168 O O   . ILE A 1 295 ? 137.846 166.912 145.014 1.00 65.77  ?  280 ILE R O   1 
ATOM   1169 C CB  . ILE A 1 295 ? 136.351 168.869 147.231 1.00 65.77  ?  280 ILE R CB  1 
ATOM   1170 C CG1 . ILE A 1 295 ? 135.041 168.920 148.012 1.00 65.77  ?  280 ILE R CG1 1 
ATOM   1171 C CG2 . ILE A 1 295 ? 136.124 169.490 145.869 1.00 65.77  ?  280 ILE R CG2 1 
ATOM   1172 C CD1 . ILE A 1 295 ? 134.558 170.321 148.300 1.00 65.77  ?  280 ILE R CD1 1 
ATOM   1173 N N   . GLY A 1 296 ? 139.263 167.497 146.657 1.00 66.24  ?  281 GLY R N   1 
ATOM   1174 C CA  . GLY A 1 296 ? 140.462 167.346 145.858 1.00 66.24  ?  281 GLY R CA  1 
ATOM   1175 C C   . GLY A 1 296 ? 140.842 165.923 145.505 1.00 66.24  ?  281 GLY R C   1 
ATOM   1176 O O   . GLY A 1 296 ? 141.838 165.723 144.800 1.00 66.24  ?  281 GLY R O   1 
ATOM   1177 N N   . VAL A 1 297 ? 140.089 164.930 145.971 1.00 66.60  ?  282 VAL R N   1 
ATOM   1178 C CA  . VAL A 1 297 ? 140.249 163.548 145.533 1.00 66.60  ?  282 VAL R CA  1 
ATOM   1179 C C   . VAL A 1 297 ? 139.102 163.093 144.644 1.00 66.60  ?  282 VAL R C   1 
ATOM   1180 O O   . VAL A 1 297 ? 139.351 162.426 143.628 1.00 66.60  ?  282 VAL R O   1 
ATOM   1181 C CB  . VAL A 1 297 ? 140.406 162.598 146.744 1.00 66.60  ?  282 VAL R CB  1 
ATOM   1182 C CG1 . VAL A 1 297 ? 140.456 161.135 146.338 1.00 66.60  ?  282 VAL R CG1 1 
ATOM   1183 C CG2 . VAL A 1 297 ? 141.657 162.948 147.508 1.00 66.60  ?  282 VAL R CG2 1 
ATOM   1184 N N   . THR A 1 298 ? 137.871 163.505 144.927 1.00 65.24  ?  283 THR R N   1 
ATOM   1185 C CA  . THR A 1 298 ? 136.718 163.150 144.114 1.00 65.24  ?  283 THR R CA  1 
ATOM   1186 C C   . THR A 1 298 ? 136.671 163.945 142.808 1.00 65.24  ?  283 THR R C   1 
ATOM   1187 O O   . THR A 1 298 ? 136.030 163.511 141.847 1.00 65.24  ?  283 THR R O   1 
ATOM   1188 C CB  . THR A 1 298 ? 135.445 163.366 144.949 1.00 65.24  ?  283 THR R CB  1 
ATOM   1189 O OG1 . THR A 1 298 ? 135.629 162.740 146.223 1.00 65.24  ?  283 THR R OG1 1 
ATOM   1190 C CG2 . THR A 1 298 ? 134.217 162.721 144.321 1.00 65.24  ?  283 THR R CG2 1 
ATOM   1191 N N   . SER A 1 299 ? 137.414 165.047 142.706 1.00 67.36  ?  284 SER R N   1 
ATOM   1192 C CA  . SER A 1 299 ? 137.475 165.808 141.462 1.00 67.36  ?  284 SER R CA  1 
ATOM   1193 C C   . SER A 1 299 ? 138.482 165.211 140.486 1.00 67.36  ?  284 SER R C   1 
ATOM   1194 O O   . SER A 1 299 ? 138.185 165.075 139.298 1.00 67.36  ?  284 SER R O   1 
ATOM   1195 C CB  . SER A 1 299 ? 137.821 167.275 141.731 1.00 67.36  ?  284 SER R CB  1 
ATOM   1196 O OG  . SER A 1 299 ? 139.161 167.408 142.165 1.00 67.36  ?  284 SER R OG  1 
ATOM   1197 N N   . VAL A 1 300 ? 139.673 164.841 140.962 1.00 65.71  ?  285 VAL R N   1 
ATOM   1198 C CA  . VAL A 1 300 ? 140.691 164.297 140.075 1.00 65.71  ?  285 VAL R CA  1 
ATOM   1199 C C   . VAL A 1 300 ? 140.385 162.875 139.629 1.00 65.71  ?  285 VAL R C   1 
ATOM   1200 O O   . VAL A 1 300 ? 141.005 162.392 138.685 1.00 65.71  ?  285 VAL R O   1 
ATOM   1201 C CB  . VAL A 1 300 ? 142.087 164.350 140.731 1.00 65.71  ?  285 VAL R CB  1 
ATOM   1202 C CG1 . VAL A 1 300 ? 142.456 165.781 141.061 1.00 65.71  ?  285 VAL R CG1 1 
ATOM   1203 C CG2 . VAL A 1 300 ? 142.137 163.479 141.964 1.00 65.71  ?  285 VAL R CG2 1 
ATOM   1204 N N   . LEU A 1 301 ? 139.444 162.193 140.276 1.00 63.90  ?  286 LEU R N   1 
ATOM   1205 C CA  . LEU A 1 301 ? 138.962 160.914 139.780 1.00 63.90  ?  286 LEU R CA  1 
ATOM   1206 C C   . LEU A 1 301 ? 137.772 161.047 138.845 1.00 63.90  ?  286 LEU R C   1 
ATOM   1207 O O   . LEU A 1 301 ? 137.341 160.041 138.275 1.00 63.90  ?  286 LEU R O   1 
ATOM   1208 C CB  . LEU A 1 301 ? 138.591 159.982 140.937 1.00 63.90  ?  286 LEU R CB  1 
ATOM   1209 C CG  . LEU A 1 301 ? 139.673 159.040 141.465 1.00 63.90  ?  286 LEU R CG  1 
ATOM   1210 C CD1 . LEU A 1 301 ? 140.793 159.768 142.181 1.00 63.90  ?  286 LEU R CD1 1 
ATOM   1211 C CD2 . LEU A 1 301 ? 139.029 158.018 142.382 1.00 63.90  ?  286 LEU R CD2 1 
ATOM   1212 N N   . LEU A 1 302 ? 137.226 162.247 138.678 1.00 62.60  ?  287 LEU R N   1 
ATOM   1213 C CA  . LEU A 1 302 ? 136.246 162.506 137.634 1.00 62.60  ?  287 LEU R CA  1 
ATOM   1214 C C   . LEU A 1 302 ? 136.871 163.159 136.415 1.00 62.60  ?  287 LEU R C   1 
ATOM   1215 O O   . LEU A 1 302 ? 136.151 163.518 135.482 1.00 62.60  ?  287 LEU R O   1 
ATOM   1216 C CB  . LEU A 1 302 ? 135.108 163.378 138.163 1.00 62.60  ?  287 LEU R CB  1 
ATOM   1217 C CG  . LEU A 1 302 ? 134.218 162.722 139.215 1.00 62.60  ?  287 LEU R CG  1 
ATOM   1218 C CD1 . LEU A 1 302 ? 133.180 163.707 139.712 1.00 62.60  ?  287 LEU R CD1 1 
ATOM   1219 C CD2 . LEU A 1 302 ? 133.563 161.465 138.680 1.00 62.60  ?  287 LEU R CD2 1 
ATOM   1220 N N   . LEU A 1 303 ? 138.186 163.346 136.413 1.00 61.93  ?  288 LEU R N   1 
ATOM   1221 C CA  . LEU A 1 303 ? 138.921 163.774 135.232 1.00 61.93  ?  288 LEU R CA  1 
ATOM   1222 C C   . LEU A 1 303 ? 139.799 162.650 134.689 1.00 61.93  ?  288 LEU R C   1 
ATOM   1223 O O   . LEU A 1 303 ? 140.683 162.881 133.863 1.00 61.93  ?  288 LEU R O   1 
ATOM   1224 C CB  . LEU A 1 303 ? 139.743 165.027 135.527 1.00 61.93  ?  288 LEU R CB  1 
ATOM   1225 C CG  . LEU A 1 303 ? 139.042 166.381 135.348 1.00 61.93  ?  288 LEU R CG  1 
ATOM   1226 C CD1 . LEU A 1 303 ? 137.973 166.668 136.384 1.00 61.93  ?  288 LEU R CD1 1 
ATOM   1227 C CD2 . LEU A 1 303 ? 140.073 167.489 135.360 1.00 61.93  ?  288 LEU R CD2 1 
ATOM   1228 N N   . PHE A 1 304 ? 139.572 161.428 135.172 1.00 60.17  ?  289 PHE R N   1 
ATOM   1229 C CA  . PHE A 1 304 ? 139.992 160.229 134.465 1.00 60.17  ?  289 PHE R CA  1 
ATOM   1230 C C   . PHE A 1 304 ? 138.808 159.417 133.965 1.00 60.17  ?  289 PHE R C   1 
ATOM   1231 O O   . PHE A 1 304 ? 139.000 158.265 133.570 1.00 60.17  ?  289 PHE R O   1 
ATOM   1232 C CB  . PHE A 1 304 ? 140.876 159.330 135.342 1.00 60.17  ?  289 PHE R CB  1 
ATOM   1233 C CG  . PHE A 1 304 ? 142.260 159.862 135.575 1.00 60.17  ?  289 PHE R CG  1 
ATOM   1234 C CD1 . PHE A 1 304 ? 143.224 159.777 134.584 1.00 60.17  ?  289 PHE R CD1 1 
ATOM   1235 C CD2 . PHE A 1 304 ? 142.614 160.397 136.801 1.00 60.17  ?  289 PHE R CD2 1 
ATOM   1236 C CE1 . PHE A 1 304 ? 144.510 160.252 134.801 1.00 60.17  ?  289 PHE R CE1 1 
ATOM   1237 C CE2 . PHE A 1 304 ? 143.898 160.875 137.027 1.00 60.17  ?  289 PHE R CE2 1 
ATOM   1238 C CZ  . PHE A 1 304 ? 144.846 160.800 136.026 1.00 60.17  ?  289 PHE R CZ  1 
ATOM   1239 N N   . ILE A 1 305 ? 137.597 159.961 134.000 1.00 59.21  ?  290 ILE R N   1 
ATOM   1240 C CA  . ILE A 1 305 ? 136.422 159.322 133.430 1.00 59.21  ?  290 ILE R CA  1 
ATOM   1241 C C   . ILE A 1 305 ? 135.941 160.091 132.196 1.00 59.21  ?  290 ILE R C   1 
ATOM   1242 O O   . ILE A 1 305 ? 135.368 159.510 131.278 1.00 59.21  ?  290 ILE R O   1 
ATOM   1243 C CB  . ILE A 1 305 ? 135.319 159.171 134.496 1.00 59.21  ?  290 ILE R CB  1 
ATOM   1244 C CG1 . ILE A 1 305 ? 135.843 158.360 135.677 1.00 59.21  ?  290 ILE R CG1 1 
ATOM   1245 C CG2 . ILE A 1 305 ? 134.094 158.444 133.982 1.00 59.21  ?  290 ILE R CG2 1 
ATOM   1246 C CD1 . ILE A 1 305 ? 134.884 158.302 136.844 1.00 59.21  ?  290 ILE R CD1 1 
ATOM   1247 N N   . VAL A 1 306 ? 136.270 161.378 132.106 1.00 58.58  ?  291 VAL R N   1 
ATOM   1248 C CA  . VAL A 1 306 ? 135.855 162.198 130.973 1.00 58.58  ?  291 VAL R CA  1 
ATOM   1249 C C   . VAL A 1 306 ? 137.078 162.294 130.058 1.00 58.58  ?  291 VAL R C   1 
ATOM   1250 O O   . VAL A 1 306 ? 137.126 163.075 129.102 1.00 58.58  ?  291 VAL R O   1 
ATOM   1251 C CB  . VAL A 1 306 ? 135.320 163.562 131.468 1.00 58.58  ?  291 VAL R CB  1 
ATOM   1252 C CG1 . VAL A 1 306 ? 134.565 164.356 130.385 1.00 58.58  ?  291 VAL R CG1 1 
ATOM   1253 C CG2 . VAL A 1 306 ? 134.412 163.355 132.667 1.00 58.58  ?  291 VAL R CG2 1 
ATOM   1254 N N   . TYR A 1 307 ? 138.071 161.457 130.330 1.00 56.71  ?  292 TYR R N   1 
ATOM   1255 C CA  . TYR A 1 307 ? 139.129 161.184 129.370 1.00 56.71  ?  292 TYR R CA  1 
ATOM   1256 C C   . TYR A 1 307 ? 139.124 159.739 128.912 1.00 56.71  ?  292 TYR R C   1 
ATOM   1257 O O   . TYR A 1 307 ? 139.534 159.468 127.781 1.00 56.71  ?  292 TYR R O   1 
ATOM   1258 C CB  . TYR A 1 307 ? 140.503 161.522 129.968 1.00 56.71  ?  292 TYR R CB  1 
ATOM   1259 C CG  . TYR A 1 307 ? 141.666 161.247 129.047 1.00 56.71  ?  292 TYR R CG  1 
ATOM   1260 C CD1 . TYR A 1 307 ? 141.956 162.097 127.991 1.00 56.71  ?  292 TYR R CD1 1 
ATOM   1261 C CD2 . TYR A 1 307 ? 142.468 160.132 129.233 1.00 56.71  ?  292 TYR R CD2 1 
ATOM   1262 C CE1 . TYR A 1 307 ? 143.017 161.847 127.149 1.00 56.71  ?  292 TYR R CE1 1 
ATOM   1263 C CE2 . TYR A 1 307 ? 143.524 159.873 128.398 1.00 56.71  ?  292 TYR R CE2 1 
ATOM   1264 C CZ  . TYR A 1 307 ? 143.796 160.732 127.360 1.00 56.71  ?  292 TYR R CZ  1 
ATOM   1265 O OH  . TYR A 1 307 ? 144.856 160.471 126.528 1.00 56.71  ?  292 TYR R OH  1 
ATOM   1266 N N   . ALA A 1 308 ? 138.640 158.811 129.731 1.00 54.17  ?  293 ALA R N   1 
ATOM   1267 C CA  . ALA A 1 308 ? 138.576 157.409 129.369 1.00 54.17  ?  293 ALA R CA  1 
ATOM   1268 C C   . ALA A 1 308 ? 137.324 157.033 128.598 1.00 54.17  ?  293 ALA R C   1 
ATOM   1269 O O   . ALA A 1 308 ? 137.155 155.855 128.279 1.00 54.17  ?  293 ALA R O   1 
ATOM   1270 C CB  . ALA A 1 308 ? 138.669 156.531 130.623 1.00 54.17  ?  293 ALA R CB  1 
ATOM   1271 N N   . TYR A 1 309 ? 136.419 157.974 128.341 1.00 54.85  ?  294 TYR R N   1 
ATOM   1272 C CA  . TYR A 1 309 ? 135.370 157.766 127.356 1.00 54.85  ?  294 TYR R CA  1 
ATOM   1273 C C   . TYR A 1 309 ? 135.457 158.759 126.204 1.00 54.85  ?  294 TYR R C   1 
ATOM   1274 O O   . TYR A 1 309 ? 134.513 158.866 125.418 1.00 54.85  ?  294 TYR R O   1 
ATOM   1275 C CB  . TYR A 1 309 ? 133.982 157.844 127.992 1.00 54.85  ?  294 TYR R CB  1 
ATOM   1276 C CG  . TYR A 1 309 ? 133.706 156.812 129.059 1.00 54.85  ?  294 TYR R CG  1 
ATOM   1277 C CD1 . TYR A 1 309 ? 133.720 155.457 128.765 1.00 54.85  ?  294 TYR R CD1 1 
ATOM   1278 C CD2 . TYR A 1 309 ? 133.328 157.194 130.336 1.00 54.85  ?  294 TYR R CD2 1 
ATOM   1279 C CE1 . TYR A 1 309 ? 133.439 154.513 129.731 1.00 54.85  ?  294 TYR R CE1 1 
ATOM   1280 C CE2 . TYR A 1 309 ? 133.039 156.257 131.307 1.00 54.85  ?  294 TYR R CE2 1 
ATOM   1281 C CZ  . TYR A 1 309 ? 133.096 154.919 130.997 1.00 54.85  ?  294 TYR R CZ  1 
ATOM   1282 O OH  . TYR A 1 309 ? 132.811 153.984 131.961 1.00 54.85  ?  294 TYR R OH  1 
ATOM   1283 N N   . MET A 1 310 ? 136.564 159.491 126.091 1.00 58.93  ?  295 MET R N   1 
ATOM   1284 C CA  . MET A 1 310 ? 136.836 160.343 124.940 1.00 58.93  ?  295 MET R CA  1 
ATOM   1285 C C   . MET A 1 310 ? 138.120 159.905 124.252 1.00 58.93  ?  295 MET R C   1 
ATOM   1286 O O   . MET A 1 310 ? 138.747 160.682 123.529 1.00 58.93  ?  295 MET R O   1 
ATOM   1287 C CB  . MET A 1 310 ? 136.912 161.815 125.341 1.00 58.93  ?  295 MET R CB  1 
ATOM   1288 C CG  . MET A 1 310 ? 135.574 162.431 125.688 1.00 58.93  ?  295 MET R CG  1 
ATOM   1289 S SD  . MET A 1 310 ? 135.736 164.131 126.258 1.00 58.93  ?  295 MET R SD  1 
ATOM   1290 C CE  . MET A 1 310 ? 136.287 164.937 124.759 1.00 58.93  ?  295 MET R CE  1 
ATOM   1291 N N   . TYR A 1 311 ? 138.524 158.661 124.493 1.00 58.01  ?  296 TYR R N   1 
ATOM   1292 C CA  . TYR A 1 311 ? 139.563 158.001 123.727 1.00 58.01  ?  296 TYR R CA  1 
ATOM   1293 C C   . TYR A 1 311 ? 139.037 156.728 123.088 1.00 58.01  ?  296 TYR R C   1 
ATOM   1294 O O   . TYR A 1 311 ? 139.628 156.243 122.122 1.00 58.01  ?  296 TYR R O   1 
ATOM   1295 C CB  . TYR A 1 311 ? 140.766 157.679 124.621 1.00 58.01  ?  296 TYR R CB  1 
ATOM   1296 C CG  . TYR A 1 311 ? 141.961 157.103 123.908 1.00 58.01  ?  296 TYR R CG  1 
ATOM   1297 C CD1 . TYR A 1 311 ? 142.818 157.917 123.187 1.00 58.01  ?  296 TYR R CD1 1 
ATOM   1298 C CD2 . TYR A 1 311 ? 142.231 155.744 123.958 1.00 58.01  ?  296 TYR R CD2 1 
ATOM   1299 C CE1 . TYR A 1 311 ? 143.917 157.395 122.537 1.00 58.01  ?  296 TYR R CE1 1 
ATOM   1300 C CE2 . TYR A 1 311 ? 143.323 155.210 123.313 1.00 58.01  ?  296 TYR R CE2 1 
ATOM   1301 C CZ  . TYR A 1 311 ? 144.163 156.040 122.603 1.00 58.01  ?  296 TYR R CZ  1 
ATOM   1302 O OH  . TYR A 1 311 ? 145.257 155.518 121.954 1.00 58.01  ?  296 TYR R OH  1 
ATOM   1303 N N   . ILE A 1 312 ? 137.930 156.193 123.583 1.00 53.87  ?  297 ILE R N   1 
ATOM   1304 C CA  . ILE A 1 312 ? 137.214 155.108 122.937 1.00 53.87  ?  297 ILE R CA  1 
ATOM   1305 C C   . ILE A 1 312 ? 136.375 155.636 121.771 1.00 53.87  ?  297 ILE R C   1 
ATOM   1306 O O   . ILE A 1 312 ? 136.236 154.968 120.747 1.00 53.87  ?  297 ILE R O   1 
ATOM   1307 C CB  . ILE A 1 312 ? 136.392 154.315 123.976 1.00 53.87  ?  297 ILE R CB  1 
ATOM   1308 C CG1 . ILE A 1 312 ? 137.294 153.307 124.696 1.00 53.87  ?  297 ILE R CG1 1 
ATOM   1309 C CG2 . ILE A 1 312 ? 135.163 153.618 123.401 1.00 53.87  ?  297 ILE R CG2 1 
ATOM   1310 C CD1 . ILE A 1 312 ? 138.014 153.808 125.906 1.00 53.87  ?  297 ILE R CD1 1 
ATOM   1311 N N   . LEU A 1 313 ? 135.933 156.887 121.847 1.00 53.68  ?  298 LEU R N   1 
ATOM   1312 C CA  . LEU A 1 313 ? 135.205 157.487 120.745 1.00 53.68  ?  298 LEU R CA  1 
ATOM   1313 C C   . LEU A 1 313 ? 136.141 158.161 119.740 1.00 53.68  ?  298 LEU R C   1 
ATOM   1314 O O   . LEU A 1 313 ? 135.683 158.585 118.676 1.00 53.68  ?  298 LEU R O   1 
ATOM   1315 C CB  . LEU A 1 313 ? 134.156 158.472 121.289 1.00 53.68  ?  298 LEU R CB  1 
ATOM   1316 C CG  . LEU A 1 313 ? 133.015 158.977 120.407 1.00 53.68  ?  298 LEU R CG  1 
ATOM   1317 C CD1 . LEU A 1 313 ? 132.224 157.802 119.897 1.00 53.68  ?  298 LEU R CD1 1 
ATOM   1318 C CD2 . LEU A 1 313 ? 132.119 159.902 121.191 1.00 53.68  ?  298 LEU R CD2 1 
ATOM   1319 N N   . TRP A 1 314 ? 137.446 158.216 120.009 1.00 55.54  ?  299 TRP R N   1 
ATOM   1320 C CA  . TRP A 1 314 ? 138.410 158.606 118.987 1.00 55.54  ?  299 TRP R CA  1 
ATOM   1321 C C   . TRP A 1 314 ? 139.117 157.410 118.364 1.00 55.54  ?  299 TRP R C   1 
ATOM   1322 O O   . TRP A 1 314 ? 139.429 157.445 117.170 1.00 55.54  ?  299 TRP R O   1 
ATOM   1323 C CB  . TRP A 1 314 ? 139.456 159.571 119.548 1.00 55.54  ?  299 TRP R CB  1 
ATOM   1324 C CG  . TRP A 1 314 ? 140.512 159.958 118.549 1.00 55.54  ?  299 TRP R CG  1 
ATOM   1325 C CD1 . TRP A 1 314 ? 141.751 159.408 118.421 1.00 55.54  ?  299 TRP R CD1 1 
ATOM   1326 C CD2 . TRP A 1 314 ? 140.426 160.981 117.555 1.00 55.54  ?  299 TRP R CD2 1 
ATOM   1327 N NE1 . TRP A 1 314 ? 142.437 160.014 117.404 1.00 55.54  ?  299 TRP R NE1 1 
ATOM   1328 C CE2 . TRP A 1 314 ? 141.646 160.987 116.856 1.00 55.54  ?  299 TRP R CE2 1 
ATOM   1329 C CE3 . TRP A 1 314 ? 139.437 161.892 117.187 1.00 55.54  ?  299 TRP R CE3 1 
ATOM   1330 C CZ2 . TRP A 1 314 ? 141.905 161.868 115.812 1.00 55.54  ?  299 TRP R CZ2 1 
ATOM   1331 C CZ3 . TRP A 1 314 ? 139.695 162.767 116.149 1.00 55.54  ?  299 TRP R CZ3 1 
ATOM   1332 C CH2 . TRP A 1 314 ? 140.919 162.748 115.474 1.00 55.54  ?  299 TRP R CH2 1 
ATOM   1333 N N   . LYS A 1 315 ? 139.367 156.349 119.119 1.00 56.01  ?  300 LYS R N   1 
ATOM   1334 C CA  . LYS A 1 315 ? 140.008 155.176 118.550 1.00 56.01  ?  300 LYS R CA  1 
ATOM   1335 C C   . LYS A 1 315 ? 139.063 154.348 117.700 1.00 56.01  ?  300 LYS R C   1 
ATOM   1336 O O   . LYS A 1 315 ? 139.488 153.812 116.677 1.00 56.01  ?  300 LYS R O   1 
ATOM   1337 C CB  . LYS A 1 315 ? 140.603 154.297 119.662 1.00 56.01  ?  300 LYS R CB  1 
ATOM   1338 C CG  . LYS A 1 315 ? 141.394 153.089 119.186 1.00 56.01  ?  300 LYS R CG  1 
ATOM   1339 C CD  . LYS A 1 315 ? 142.645 153.491 118.426 1.00 56.01  ?  300 LYS R CD  1 
ATOM   1340 C CE  . LYS A 1 315 ? 143.689 154.086 119.354 1.00 56.01  ?  300 LYS R CE  1 
ATOM   1341 N NZ  . LYS A 1 315 ? 144.944 154.428 118.634 1.00 56.01  ?  300 LYS R NZ  1 
ATOM   1342 N N   . ALA A 1 316 ? 137.783 154.281 118.059 1.00 53.00  ?  301 ALA R N   1 
ATOM   1343 C CA  . ALA A 1 316 ? 136.784 153.622 117.232 1.00 53.00  ?  301 ALA R CA  1 
ATOM   1344 C C   . ALA A 1 316 ? 136.272 154.501 116.100 1.00 53.00  ?  301 ALA R C   1 
ATOM   1345 O O   . ALA A 1 316 ? 135.318 154.106 115.426 1.00 53.00  ?  301 ALA R O   1 
ATOM   1346 C CB  . ALA A 1 316 ? 135.604 153.162 118.086 1.00 53.00  ?  301 ALA R CB  1 
ATOM   1347 N N   . HIS A 1 317 ? 136.853 155.680 115.882 1.00 54.87  ?  302 HIS R N   1 
ATOM   1348 C CA  . HIS A 1 317 ? 136.449 156.510 114.755 1.00 54.87  ?  302 HIS R CA  1 
ATOM   1349 C C   . HIS A 1 317 ? 137.452 156.464 113.612 1.00 54.87  ?  302 HIS R C   1 
ATOM   1350 O O   . HIS A 1 317 ? 137.050 156.414 112.447 1.00 54.87  ?  302 HIS R O   1 
ATOM   1351 C CB  . HIS A 1 317 ? 136.242 157.959 115.173 1.00 54.87  ?  302 HIS R CB  1 
ATOM   1352 C CG  . HIS A 1 317 ? 135.864 158.849 114.034 1.00 54.87  ?  302 HIS R CG  1 
ATOM   1353 N ND1 . HIS A 1 317 ? 134.639 158.771 113.407 1.00 54.87  ?  302 HIS R ND1 1 
ATOM   1354 C CD2 . HIS A 1 317 ? 136.552 159.825 113.397 1.00 54.87  ?  302 HIS R CD2 1 
ATOM   1355 C CE1 . HIS A 1 317 ? 134.586 159.664 112.437 1.00 54.87  ?  302 HIS R CE1 1 
ATOM   1356 N NE2 . HIS A 1 317 ? 135.733 160.318 112.410 1.00 54.87  ?  302 HIS R NE2 1 
ATOM   1357 N N   . SER A 1 318 ? 138.748 156.528 113.919 1.00 56.72  ?  303 SER R N   1 
ATOM   1358 C CA  . SER A 1 318 ? 139.772 156.371 112.891 1.00 56.72  ?  303 SER R CA  1 
ATOM   1359 C C   . SER A 1 318 ? 139.739 154.952 112.340 1.00 56.72  ?  303 SER R C   1 
ATOM   1360 O O   . SER A 1 318 ? 139.941 154.735 111.142 1.00 56.72  ?  303 SER R O   1 
ATOM   1361 C CB  . SER A 1 318 ? 141.159 156.694 113.442 1.00 56.72  ?  303 SER R CB  1 
ATOM   1362 O OG  . SER A 1 318 ? 141.561 155.723 114.388 1.00 56.72  ?  303 SER R OG  1 
ATOM   1363 N N   . HIS A 1 319 ? 139.491 153.984 113.218 1.00 53.89  ?  304 HIS R N   1 
ATOM   1364 C CA  . HIS A 1 319 ? 139.275 152.593 112.842 1.00 53.89  ?  304 HIS R CA  1 
ATOM   1365 C C   . HIS A 1 319 ? 138.039 152.404 111.968 1.00 53.89  ?  304 HIS R C   1 
ATOM   1366 O O   . HIS A 1 319 ? 138.005 151.505 111.124 1.00 53.89  ?  304 HIS R O   1 
ATOM   1367 C CB  . HIS A 1 319 ? 139.166 151.733 114.100 1.00 53.89  ?  304 HIS R CB  1 
ATOM   1368 C CG  . HIS A 1 319 ? 138.929 150.286 113.822 1.00 53.89  ?  304 HIS R CG  1 
ATOM   1369 N ND1 . HIS A 1 319 ? 137.664 149.754 113.713 1.00 53.89  ?  304 HIS R ND1 1 
ATOM   1370 C CD2 . HIS A 1 319 ? 139.789 149.265 113.610 1.00 53.89  ?  304 HIS R CD2 1 
ATOM   1371 C CE1 . HIS A 1 319 ? 137.754 148.463 113.459 1.00 53.89  ?  304 HIS R CE1 1 
ATOM   1372 N NE2 . HIS A 1 319 ? 139.033 148.141 113.389 1.00 53.89  ?  304 HIS R NE2 1 
ATOM   1373 N N   . ALA A 1 320 ? 137.016 153.231 112.171 1.00 55.08  ?  305 ALA R N   1 
ATOM   1374 C CA  . ALA A 1 320 ? 135.774 153.149 111.408 1.00 55.08  ?  305 ALA R CA  1 
ATOM   1375 C C   . ALA A 1 320 ? 135.950 153.452 109.924 1.00 55.08  ?  305 ALA R C   1 
ATOM   1376 O O   . ALA A 1 320 ? 135.062 153.151 109.126 1.00 55.08  ?  305 ALA R O   1 
ATOM   1377 C CB  . ALA A 1 320 ? 134.725 154.090 111.996 1.00 55.08  ?  305 ALA R CB  1 
ATOM   1378 N N   . VAL A 1 321 ? 137.050 154.098 109.545 1.00 54.25  ?  306 VAL R N   1 
ATOM   1379 C CA  . VAL A 1 321 ? 137.309 154.414 108.146 1.00 54.25  ?  306 VAL R CA  1 
ATOM   1380 C C   . VAL A 1 321 ? 137.692 153.158 107.371 1.00 54.25  ?  306 VAL R C   1 
ATOM   1381 O O   . VAL A 1 321 ? 137.143 152.883 106.299 1.00 54.25  ?  306 VAL R O   1 
ATOM   1382 C CB  . VAL A 1 321 ? 138.397 155.495 108.026 1.00 54.25  ?  306 VAL R CB  1 
ATOM   1383 C CG1 . VAL A 1 321 ? 138.726 155.766 106.575 1.00 54.25  ?  306 VAL R CG1 1 
ATOM   1384 C CG2 . VAL A 1 321 ? 137.936 156.767 108.692 1.00 54.25  ?  306 VAL R CG2 1 
ATOM   1385 N N   . ARG A 1 322 ? 138.618 152.373 107.912 1.00 57.39  ?  307 ARG R N   1 
ATOM   1386 C CA  . ARG A 1 322 ? 139.278 151.344 107.116 1.00 57.39  ?  307 ARG R CA  1 
ATOM   1387 C C   . ARG A 1 322 ? 138.449 150.083 106.915 1.00 57.39  ?  307 ARG R C   1 
ATOM   1388 O O   . ARG A 1 322 ? 138.276 149.641 105.777 1.00 57.39  ?  307 ARG R O   1 
ATOM   1389 C CB  . ARG A 1 322 ? 140.625 150.997 107.746 1.00 57.39  ?  307 ARG R CB  1 
ATOM   1390 C CG  . ARG A 1 322 ? 141.648 152.097 107.563 1.00 57.39  ?  307 ARG R CG  1 
ATOM   1391 C CD  . ARG A 1 322 ? 142.985 151.695 108.112 1.00 57.39  ?  307 ARG R CD  1 
ATOM   1392 N NE  . ARG A 1 322 ? 142.931 151.533 109.559 1.00 57.39  ?  307 ARG R NE  1 
ATOM   1393 C CZ  . ARG A 1 322 ? 143.107 152.526 110.422 1.00 57.39  ?  307 ARG R CZ  1 
ATOM   1394 N NH1 . ARG A 1 322 ? 143.045 152.296 111.725 1.00 57.39  ?  307 ARG R NH1 1 
ATOM   1395 N NH2 . ARG A 1 322 ? 143.344 153.751 109.981 1.00 57.39  ?  307 ARG R NH2 1 
ATOM   1396 N N   . MET A 1 323 ? 137.913 149.504 107.990 1.00 58.88  ?  308 MET R N   1 
ATOM   1397 C CA  . MET A 1 323 ? 137.182 148.242 107.896 1.00 58.88  ?  308 MET R CA  1 
ATOM   1398 C C   . MET A 1 323 ? 135.705 148.435 107.566 1.00 58.88  ?  308 MET R C   1 
ATOM   1399 O O   . MET A 1 323 ? 134.878 147.583 107.900 1.00 58.88  ?  308 MET R O   1 
ATOM   1400 C CB  . MET A 1 323 ? 137.317 147.458 109.202 1.00 58.88  ?  308 MET R CB  1 
ATOM   1401 C CG  . MET A 1 323 ? 138.674 146.820 109.414 1.00 58.88  ?  308 MET R CG  1 
ATOM   1402 S SD  . MET A 1 323 ? 138.917 146.214 111.100 1.00 58.88  ?  308 MET R SD  1 
ATOM   1403 C CE  . MET A 1 323 ? 137.750 144.865 111.226 1.00 58.88  ?  308 MET R CE  1 
ATOM   1404 N N   . ILE A 1 324 ? 135.359 149.561 106.941 1.00 58.13  ?  309 ILE R N   1 
ATOM   1405 C CA  . ILE A 1 324 ? 134.008 149.833 106.460 1.00 58.13  ?  309 ILE R CA  1 
ATOM   1406 C C   . ILE A 1 324 ? 134.071 150.296 105.009 1.00 58.13  ?  309 ILE R C   1 
ATOM   1407 O O   . ILE A 1 324 ? 133.394 149.739 104.139 1.00 58.13  ?  309 ILE R O   1 
ATOM   1408 C CB  . ILE A 1 324 ? 133.297 150.861 107.362 1.00 58.13  ?  309 ILE R CB  1 
ATOM   1409 C CG1 . ILE A 1 324 ? 132.957 150.226 108.717 1.00 58.13  ?  309 ILE R CG1 1 
ATOM   1410 C CG2 . ILE A 1 324 ? 132.063 151.434 106.682 1.00 58.13  ?  309 ILE R CG2 1 
ATOM   1411 C CD1 . ILE A 1 324 ? 132.530 151.200 109.781 1.00 58.13  ?  309 ILE R CD1 1 
ATOM   1412 N N   . GLN A 1 325 ? 134.893 151.308 104.734 1.00 56.95  ?  310 GLN R N   1 
ATOM   1413 C CA  . GLN A 1 325 ? 135.047 151.849 103.388 1.00 56.95  ?  310 GLN R CA  1 
ATOM   1414 C C   . GLN A 1 325 ? 136.007 151.031 102.531 1.00 56.95  ?  310 GLN R C   1 
ATOM   1415 O O   . GLN A 1 325 ? 135.677 150.667 101.399 1.00 56.95  ?  310 GLN R O   1 
ATOM   1416 C CB  . GLN A 1 325 ? 135.527 153.302 103.458 1.00 56.95  ?  310 GLN R CB  1 
ATOM   1417 N N   . ARG A 1 326 ? 137.201 150.748 103.049 1.00 52.35  ?  311 ARG R N   1 
ATOM   1418 C CA  . ARG A 1 326 ? 138.189 149.953 102.333 1.00 52.35  ?  311 ARG R CA  1 
ATOM   1419 C C   . ARG A 1 326 ? 138.000 148.461 102.581 1.00 52.35  ?  311 ARG R C   1 
ATOM   1420 O O   . ARG A 1 326 ? 138.176 147.660 101.657 1.00 52.35  ?  311 ARG R O   1 
ATOM   1421 C CB  . ARG A 1 326 ? 139.589 150.401 102.785 1.00 52.35  ?  311 ARG R CB  1 
ATOM   1422 C CG  . ARG A 1 326 ? 140.778 150.130 101.861 1.00 52.35  ?  311 ARG R CG  1 
ATOM   1423 C CD  . ARG A 1 326 ? 141.465 148.787 102.095 1.00 52.35  ?  311 ARG R CD  1 
ATOM   1424 N NE  . ARG A 1 326 ? 141.843 148.533 103.483 1.00 52.35  ?  311 ARG R NE  1 
ATOM   1425 C CZ  . ARG A 1 326 ? 142.192 147.333 103.926 1.00 52.35  ?  311 ARG R CZ  1 
ATOM   1426 N NH1 . ARG A 1 326 ? 142.507 147.135 105.197 1.00 52.35  ?  311 ARG R NH1 1 
ATOM   1427 N NH2 . ARG A 1 326 ? 142.225 146.328 103.076 1.00 52.35  ?  311 ARG R NH2 1 
ATOM   1428 N N   . GLY A 1 327 ? 137.571 148.095 103.787 1.00 54.10  ?  312 GLY R N   1 
ATOM   1429 C CA  . GLY A 1 327 ? 137.731 146.764 104.344 1.00 54.10  ?  312 GLY R CA  1 
ATOM   1430 C C   . GLY A 1 327 ? 136.990 145.604 103.725 1.00 54.10  ?  312 GLY R C   1 
ATOM   1431 O O   . GLY A 1 327 ? 137.491 144.479 103.765 1.00 54.10  ?  312 GLY R O   1 
ATOM   1432 N N   . THR A 1 328 ? 135.805 145.850 103.178 1.00 53.72  ?  313 THR R N   1 
ATOM   1433 C CA  . THR A 1 328 ? 134.977 144.794 102.605 1.00 53.72  ?  313 THR R CA  1 
ATOM   1434 C C   . THR A 1 328 ? 135.042 144.814 101.084 1.00 53.72  ?  313 THR R C   1 
ATOM   1435 O O   . THR A 1 328 ? 135.846 145.538 100.497 1.00 53.72  ?  313 THR R O   1 
ATOM   1436 C CB  . THR A 1 328 ? 133.504 144.921 103.033 1.00 53.72  ?  313 THR R CB  1 
ATOM   1437 O OG1 . THR A 1 328 ? 132.922 146.083 102.430 1.00 53.72  ?  313 THR R OG1 1 
ATOM   1438 C CG2 . THR A 1 328 ? 133.397 145.051 104.539 1.00 53.72  ?  313 THR R CG2 1 
ATOM   1439 N N   . ALA A 1 350 ? 131.226 154.893 110.695 1.00 66.89  ?  335 ALA R N   1 
ATOM   1440 C CA  . ALA A 1 350 ? 129.921 155.184 110.121 1.00 66.89  ?  335 ALA R CA  1 
ATOM   1441 C C   . ALA A 1 350 ? 128.954 154.026 110.342 1.00 66.89  ?  335 ALA R C   1 
ATOM   1442 O O   . ALA A 1 350 ? 127.771 154.124 110.020 1.00 66.89  ?  335 ALA R O   1 
ATOM   1443 C CB  . ALA A 1 350 ? 130.051 155.491 108.644 1.00 66.89  ?  335 ALA R CB  1 
ATOM   1444 N N   . ARG A 1 351 ? 129.466 152.921 110.882 1.00 65.68  ?  336 ARG R N   1 
ATOM   1445 C CA  . ARG A 1 351 ? 128.630 151.773 111.215 1.00 65.68  ?  336 ARG R CA  1 
ATOM   1446 C C   . ARG A 1 351 ? 128.885 151.349 112.654 1.00 65.68  ?  336 ARG R C   1 
ATOM   1447 O O   . ARG A 1 351 ? 127.986 150.840 113.332 1.00 65.68  ?  336 ARG R O   1 
ATOM   1448 C CB  . ARG A 1 351 ? 128.914 150.606 110.269 1.00 65.68  ?  336 ARG R CB  1 
ATOM   1449 C CG  . ARG A 1 351 ? 128.612 150.885 108.807 1.00 65.68  ?  336 ARG R CG  1 
ATOM   1450 C CD  . ARG A 1 351 ? 128.922 149.682 107.938 1.00 65.68  ?  336 ARG R CD  1 
ATOM   1451 N NE  . ARG A 1 351 ? 128.668 149.958 106.528 1.00 65.68  ?  336 ARG R NE  1 
ATOM   1452 C CZ  . ARG A 1 351 ? 128.857 149.080 105.551 1.00 65.68  ?  336 ARG R CZ  1 
ATOM   1453 N NH1 . ARG A 1 351 ? 128.601 149.417 104.294 1.00 65.68  ?  336 ARG R NH1 1 
ATOM   1454 N NH2 . ARG A 1 351 ? 129.299 147.863 105.832 1.00 65.68  ?  336 ARG R NH2 1 
ATOM   1455 N N   . MET A 1 352 ? 130.119 151.561 113.121 1.00 61.70  ?  337 MET R N   1 
ATOM   1456 C CA  . MET A 1 352 ? 130.548 151.186 114.461 1.00 61.70  ?  337 MET R CA  1 
ATOM   1457 C C   . MET A 1 352 ? 130.622 152.358 115.427 1.00 61.70  ?  337 MET R C   1 
ATOM   1458 O O   . MET A 1 352 ? 130.260 152.196 116.595 1.00 61.70  ?  337 MET R O   1 
ATOM   1459 C CB  . MET A 1 352 ? 131.923 150.499 114.400 1.00 61.70  ?  337 MET R CB  1 
ATOM   1460 C CG  . MET A 1 352 ? 132.464 150.014 115.734 1.00 61.70  ?  337 MET R CG  1 
ATOM   1461 S SD  . MET A 1 352 ? 134.046 149.179 115.578 1.00 61.70  ?  337 MET R SD  1 
ATOM   1462 C CE  . MET A 1 352 ? 134.472 148.971 117.299 1.00 61.70  ?  337 MET R CE  1 
ATOM   1463 N N   . ASP A 1 353 ? 131.045 153.535 114.976 1.00 61.59  ?  338 ASP R N   1 
ATOM   1464 C CA  . ASP A 1 353 ? 131.140 154.682 115.864 1.00 61.59  ?  338 ASP R CA  1 
ATOM   1465 C C   . ASP A 1 353 ? 129.847 155.480 115.976 1.00 61.59  ?  338 ASP R C   1 
ATOM   1466 O O   . ASP A 1 353 ? 129.885 156.613 116.463 1.00 61.59  ?  338 ASP R O   1 
ATOM   1467 C CB  . ASP A 1 353 ? 132.291 155.603 115.429 1.00 61.59  ?  338 ASP R CB  1 
ATOM   1468 C CG  . ASP A 1 353 ? 132.178 156.062 113.985 1.00 61.59  ?  338 ASP R CG  1 
ATOM   1469 O OD1 . ASP A 1 353 ? 131.273 155.597 113.260 1.00 61.59  ?  338 ASP R OD1 1 
ATOM   1470 O OD2 . ASP A 1 353 ? 133.009 156.898 113.570 1.00 61.59  -1 338 ASP R OD2 1 
ATOM   1471 N N   . ILE A 1 354 ? 128.714 154.939 115.525 1.00 64.19  ?  339 ILE R N   1 
ATOM   1472 C CA  . ILE A 1 354 ? 127.413 155.560 115.752 1.00 64.19  ?  339 ILE R CA  1 
ATOM   1473 C C   . ILE A 1 354 ? 126.557 154.718 116.704 1.00 64.19  ?  339 ILE R C   1 
ATOM   1474 O O   . ILE A 1 354 ? 125.588 155.219 117.283 1.00 64.19  ?  339 ILE R O   1 
ATOM   1475 C CB  . ILE A 1 354 ? 126.704 155.829 114.407 1.00 64.19  ?  339 ILE R CB  1 
ATOM   1476 C CG1 . ILE A 1 354 ? 127.635 156.590 113.469 1.00 64.19  ?  339 ILE R CG1 1 
ATOM   1477 C CG2 . ILE A 1 354 ? 125.504 156.761 114.545 1.00 64.19  ?  339 ILE R CG2 1 
ATOM   1478 C CD1 . ILE A 1 354 ? 127.098 156.739 112.066 1.00 64.19  ?  339 ILE R CD1 1 
ATOM   1479 N N   . ARG A 1 355 ? 126.952 153.470 116.958 1.00 64.30  ?  340 ARG R N   1 
ATOM   1480 C CA  . ARG A 1 355 ? 126.353 152.697 118.034 1.00 64.30  ?  340 ARG R CA  1 
ATOM   1481 C C   . ARG A 1 355 ? 127.117 152.821 119.342 1.00 64.30  ?  340 ARG R C   1 
ATOM   1482 O O   . ARG A 1 355 ? 126.619 152.356 120.372 1.00 64.30  ?  340 ARG R O   1 
ATOM   1483 C CB  . ARG A 1 355 ? 126.234 151.212 117.650 1.00 64.30  ?  340 ARG R CB  1 
ATOM   1484 C CG  . ARG A 1 355 ? 127.557 150.503 117.407 1.00 64.30  ?  340 ARG R CG  1 
ATOM   1485 C CD  . ARG A 1 355 ? 127.367 149.026 117.054 1.00 64.30  ?  340 ARG R CD  1 
ATOM   1486 N NE  . ARG A 1 355 ? 126.949 148.221 118.199 1.00 64.30  ?  340 ARG R NE  1 
ATOM   1487 C CZ  . ARG A 1 355 ? 127.785 147.649 119.063 1.00 64.30  ?  340 ARG R CZ  1 
ATOM   1488 N NH1 . ARG A 1 355 ? 129.099 147.776 118.916 1.00 64.30  ?  340 ARG R NH1 1 
ATOM   1489 N NH2 . ARG A 1 355 ? 127.307 146.938 120.075 1.00 64.30  ?  340 ARG R NH2 1 
ATOM   1490 N N   . LEU A 1 356 ? 128.302 153.432 119.332 1.00 61.79  ?  341 LEU R N   1 
ATOM   1491 C CA  . LEU A 1 356 ? 128.997 153.854 120.540 1.00 61.79  ?  341 LEU R CA  1 
ATOM   1492 C C   . LEU A 1 356 ? 128.985 155.362 120.728 1.00 61.79  ?  341 LEU R C   1 
ATOM   1493 O O   . LEU A 1 356 ? 129.803 155.882 121.486 1.00 61.79  ?  341 LEU R O   1 
ATOM   1494 C CB  . LEU A 1 356 ? 130.446 153.374 120.542 1.00 61.79  ?  341 LEU R CB  1 
ATOM   1495 C CG  . LEU A 1 356 ? 130.737 151.896 120.735 1.00 61.79  ?  341 LEU R CG  1 
ATOM   1496 C CD1 . LEU A 1 356 ? 132.227 151.672 120.639 1.00 61.79  ?  341 LEU R CD1 1 
ATOM   1497 C CD2 . LEU A 1 356 ? 130.218 151.438 122.071 1.00 61.79  ?  341 LEU R CD2 1 
ATOM   1498 N N   . ALA A 1 357 ? 128.113 156.082 120.030 1.00 64.80  ?  342 ALA R N   1 
ATOM   1499 C CA  . ALA A 1 357 ? 128.009 157.523 120.215 1.00 64.80  ?  342 ALA R CA  1 
ATOM   1500 C C   . ALA A 1 357 ? 126.598 157.924 120.617 1.00 64.80  ?  342 ALA R C   1 
ATOM   1501 O O   . ALA A 1 357 ? 126.232 159.097 120.531 1.00 64.80  ?  342 ALA R O   1 
ATOM   1502 C CB  . ALA A 1 357 ? 128.440 158.274 118.958 1.00 64.80  ?  342 ALA R CB  1 
ATOM   1503 N N   . LYS A 1 358 ? 125.786 156.962 121.052 1.00 65.29  ?  343 LYS R N   1 
ATOM   1504 C CA  . LYS A 1 358 ? 124.479 157.277 121.609 1.00 65.29  ?  343 LYS R CA  1 
ATOM   1505 C C   . LYS A 1 358 ? 124.239 156.549 122.922 1.00 65.29  ?  343 LYS R C   1 
ATOM   1506 O O   . LYS A 1 358 ? 123.144 156.655 123.485 1.00 65.29  ?  343 LYS R O   1 
ATOM   1507 C CB  . LYS A 1 358 ? 123.361 156.966 120.608 1.00 65.29  ?  343 LYS R CB  1 
ATOM   1508 C CG  . LYS A 1 358 ? 123.115 155.499 120.338 1.00 65.29  ?  343 LYS R CG  1 
ATOM   1509 C CD  . LYS A 1 358 ? 121.996 155.324 119.322 1.00 65.29  ?  343 LYS R CD  1 
ATOM   1510 C CE  . LYS A 1 358 ? 121.720 153.856 119.050 1.00 65.29  ?  343 LYS R CE  1 
ATOM   1511 N NZ  . LYS A 1 358 ? 121.154 153.174 120.245 1.00 65.29  ?  343 LYS R NZ  1 
ATOM   1512 N N   . THR A 1 359 ? 125.229 155.805 123.416 1.00 64.65  ?  344 THR R N   1 
ATOM   1513 C CA  . THR A 1 359 ? 125.231 155.329 124.796 1.00 64.65  ?  344 THR R CA  1 
ATOM   1514 C C   . THR A 1 359 ? 126.351 156.019 125.559 1.00 64.65  ?  344 THR R C   1 
ATOM   1515 O O   . THR A 1 359 ? 126.238 156.208 126.771 1.00 64.65  ?  344 THR R O   1 
ATOM   1516 C CB  . THR A 1 359 ? 125.380 153.811 124.868 1.00 64.65  ?  344 THR R CB  1 
ATOM   1517 O OG1 . THR A 1 359 ? 126.670 153.437 124.372 1.00 64.65  ?  344 THR R OG1 1 
ATOM   1518 C CG2 . THR A 1 359 ? 124.308 153.136 124.040 1.00 64.65  ?  344 THR R CG2 1 
ATOM   1519 N N   . LEU A 1 360 ? 127.431 156.404 124.882 1.00 63.13  ?  345 LEU R N   1 
ATOM   1520 C CA  . LEU A 1 360 ? 128.615 156.949 125.528 1.00 63.13  ?  345 LEU R CA  1 
ATOM   1521 C C   . LEU A 1 360 ? 128.455 158.447 125.773 1.00 63.13  ?  345 LEU R C   1 
ATOM   1522 O O   . LEU A 1 360 ? 129.338 159.091 126.344 1.00 63.13  ?  345 LEU R O   1 
ATOM   1523 C CB  . LEU A 1 360 ? 129.835 156.665 124.654 1.00 63.13  ?  345 LEU R CB  1 
ATOM   1524 C CG  . LEU A 1 360 ? 131.219 156.652 125.271 1.00 63.13  ?  345 LEU R CG  1 
ATOM   1525 C CD1 . LEU A 1 360 ? 131.244 155.478 126.204 1.00 63.13  ?  345 LEU R CD1 1 
ATOM   1526 C CD2 . LEU A 1 360 ? 132.257 156.489 124.189 1.00 63.13  ?  345 LEU R CD2 1 
ATOM   1527 N N   . VAL A 1 361 ? 127.326 159.011 125.354 1.00 65.18  ?  346 VAL R N   1 
ATOM   1528 C CA  . VAL A 1 361 ? 127.036 160.422 125.570 1.00 65.18  ?  346 VAL R CA  1 
ATOM   1529 C C   . VAL A 1 361 ? 126.048 160.493 126.728 1.00 65.18  ?  346 VAL R C   1 
ATOM   1530 O O   . VAL A 1 361 ? 125.985 161.489 127.459 1.00 65.18  ?  346 VAL R O   1 
ATOM   1531 C CB  . VAL A 1 361 ? 126.499 161.071 124.275 1.00 65.18  ?  346 VAL R CB  1 
ATOM   1532 C CG1 . VAL A 1 361 ? 126.211 162.554 124.442 1.00 65.18  ?  346 VAL R CG1 1 
ATOM   1533 C CG2 . VAL A 1 361 ? 127.491 160.873 123.150 1.00 65.18  ?  346 VAL R CG2 1 
ATOM   1534 N N   . LEU A 1 362 ? 125.324 159.401 126.957 1.00 63.60  ?  347 LEU R N   1 
ATOM   1535 C CA  . LEU A 1 362 ? 124.375 159.355 128.059 1.00 63.60  ?  347 LEU R CA  1 
ATOM   1536 C C   . LEU A 1 362 ? 125.073 159.117 129.396 1.00 63.60  ?  347 LEU R C   1 
ATOM   1537 O O   . LEU A 1 362 ? 124.537 159.478 130.447 1.00 63.60  ?  347 LEU R O   1 
ATOM   1538 C CB  . LEU A 1 362 ? 123.324 158.272 127.794 1.00 63.60  ?  347 LEU R CB  1 
ATOM   1539 C CG  . LEU A 1 362 ? 122.095 158.158 128.697 1.00 63.60  ?  347 LEU R CG  1 
ATOM   1540 C CD1 . LEU A 1 362 ? 121.280 159.426 128.615 1.00 63.60  ?  347 LEU R CD1 1 
ATOM   1541 C CD2 . LEU A 1 362 ? 121.252 156.961 128.301 1.00 63.60  ?  347 LEU R CD2 1 
ATOM   1542 N N   . ILE A 1 363 ? 126.280 158.554 129.378 1.00 63.78  ?  348 ILE R N   1 
ATOM   1543 C CA  . ILE A 1 363 ? 127.023 158.271 130.601 1.00 63.78  ?  348 ILE R CA  1 
ATOM   1544 C C   . ILE A 1 363 ? 127.688 159.560 131.072 1.00 63.78  ?  348 ILE R C   1 
ATOM   1545 O O   . ILE A 1 363 ? 127.905 159.770 132.270 1.00 63.78  ?  348 ILE R O   1 
ATOM   1546 C CB  . ILE A 1 363 ? 128.045 157.143 130.356 1.00 63.78  ?  348 ILE R CB  1 
ATOM   1547 C CG1 . ILE A 1 363 ? 127.326 155.886 129.886 1.00 63.78  ?  348 ILE R CG1 1 
ATOM   1548 C CG2 . ILE A 1 363 ? 128.825 156.786 131.606 1.00 63.78  ?  348 ILE R CG2 1 
ATOM   1549 C CD1 . ILE A 1 363 ? 128.250 154.796 129.420 1.00 63.78  ?  348 ILE R CD1 1 
ATOM   1550 N N   . LEU A 1 364 ? 127.930 160.475 130.142 1.00 64.28  ?  349 LEU R N   1 
ATOM   1551 C CA  . LEU A 1 364 ? 128.577 161.734 130.478 1.00 64.28  ?  349 LEU R CA  1 
ATOM   1552 C C   . LEU A 1 364 ? 127.603 162.894 130.604 1.00 64.28  ?  349 LEU R C   1 
ATOM   1553 O O   . LEU A 1 364 ? 128.048 164.045 130.639 1.00 64.28  ?  349 LEU R O   1 
ATOM   1554 C CB  . LEU A 1 364 ? 129.652 162.086 129.436 1.00 64.28  ?  349 LEU R CB  1 
ATOM   1555 C CG  . LEU A 1 364 ? 131.059 161.497 129.569 1.00 64.28  ?  349 LEU R CG  1 
ATOM   1556 C CD1 . LEU A 1 364 ? 131.110 160.012 129.271 1.00 64.28  ?  349 LEU R CD1 1 
ATOM   1557 C CD2 . LEU A 1 364 ? 132.002 162.237 128.648 1.00 64.28  ?  349 LEU R CD2 1 
ATOM   1558 N N   . VAL A 1 365 ? 126.299 162.638 130.667 1.00 66.36  ?  350 VAL R N   1 
ATOM   1559 C CA  . VAL A 1 365 ? 125.315 163.698 130.839 1.00 66.36  ?  350 VAL R CA  1 
ATOM   1560 C C   . VAL A 1 365 ? 124.430 163.306 132.020 1.00 66.36  ?  350 VAL R C   1 
ATOM   1561 O O   . VAL A 1 365 ? 123.462 163.995 132.359 1.00 66.36  ?  350 VAL R O   1 
ATOM   1562 C CB  . VAL A 1 365 ? 124.518 163.919 129.536 1.00 66.36  ?  350 VAL R CB  1 
ATOM   1563 C CG1 . VAL A 1 365 ? 123.504 162.804 129.310 1.00 66.36  ?  350 VAL R CG1 1 
ATOM   1564 C CG2 . VAL A 1 365 ? 123.894 165.318 129.465 1.00 66.36  ?  350 VAL R CG2 1 
ATOM   1565 N N   . VAL A 1 366 ? 124.783 162.209 132.686 1.00 67.87  ?  351 VAL R N   1 
ATOM   1566 C CA  . VAL A 1 366 ? 124.081 161.800 133.896 1.00 67.87  ?  351 VAL R CA  1 
ATOM   1567 C C   . VAL A 1 366 ? 125.111 161.815 135.018 1.00 67.87  ?  351 VAL R C   1 
ATOM   1568 O O   . VAL A 1 366 ? 124.802 161.545 136.184 1.00 67.87  ?  351 VAL R O   1 
ATOM   1569 C CB  . VAL A 1 366 ? 123.427 160.416 133.724 1.00 67.87  ?  351 VAL R CB  1 
ATOM   1570 C CG1 . VAL A 1 366 ? 124.466 159.306 133.816 1.00 67.87  ?  351 VAL R CG1 1 
ATOM   1571 C CG2 . VAL A 1 366 ? 122.264 160.213 134.689 1.00 67.87  ?  351 VAL R CG2 1 
ATOM   1572 N N   . LEU A 1 367 ? 126.342 162.175 134.673 1.00 69.54  ?  352 LEU R N   1 
ATOM   1573 C CA  . LEU A 1 367 ? 127.427 162.227 135.641 1.00 69.54  ?  352 LEU R CA  1 
ATOM   1574 C C   . LEU A 1 367 ? 127.761 163.675 135.964 1.00 69.54  ?  352 LEU R C   1 
ATOM   1575 O O   . LEU A 1 367 ? 128.140 163.991 137.094 1.00 69.54  ?  352 LEU R O   1 
ATOM   1576 C CB  . LEU A 1 367 ? 128.652 161.479 135.104 1.00 69.54  ?  352 LEU R CB  1 
ATOM   1577 C CG  . LEU A 1 367 ? 129.865 161.187 135.989 1.00 69.54  ?  352 LEU R CG  1 
ATOM   1578 C CD1 . LEU A 1 367 ? 130.455 159.859 135.582 1.00 69.54  ?  352 LEU R CD1 1 
ATOM   1579 C CD2 . LEU A 1 367 ? 130.930 162.260 135.860 1.00 69.54  ?  352 LEU R CD2 1 
ATOM   1580 N N   . ILE A 1 368 ? 127.634 164.560 134.980 1.00 71.79  ?  353 ILE R N   1 
ATOM   1581 C CA  . ILE A 1 368 ? 128.032 165.950 135.153 1.00 71.79  ?  353 ILE R CA  1 
ATOM   1582 C C   . ILE A 1 368 ? 126.860 166.757 135.711 1.00 71.79  ?  353 ILE R C   1 
ATOM   1583 O O   . ILE A 1 368 ? 127.016 167.922 136.089 1.00 71.79  ?  353 ILE R O   1 
ATOM   1584 C CB  . ILE A 1 368 ? 128.562 166.522 133.822 1.00 71.79  ?  353 ILE R CB  1 
ATOM   1585 C CG1 . ILE A 1 368 ? 129.485 167.718 134.061 1.00 71.79  ?  353 ILE R CG1 1 
ATOM   1586 C CG2 . ILE A 1 368 ? 127.425 166.916 132.912 1.00 71.79  ?  353 ILE R CG2 1 
ATOM   1587 C CD1 . ILE A 1 368 ? 130.750 167.359 134.810 1.00 71.79  ?  353 ILE R CD1 1 
ATOM   1588 N N   . ILE A 1 369 ? 125.679 166.142 135.799 1.00 74.39  ?  354 ILE R N   1 
ATOM   1589 C CA  . ILE A 1 369 ? 124.517 166.827 136.360 1.00 74.39  ?  354 ILE R CA  1 
ATOM   1590 C C   . ILE A 1 369 ? 124.143 166.105 137.659 1.00 74.39  ?  354 ILE R C   1 
ATOM   1591 O O   . ILE A 1 369 ? 123.027 166.231 138.173 1.00 74.39  ?  354 ILE R O   1 
ATOM   1592 C CB  . ILE A 1 369 ? 123.356 166.877 135.341 1.00 74.39  ?  354 ILE R CB  1 
ATOM   1593 C CG1 . ILE A 1 369 ? 123.875 167.311 133.977 1.00 74.39  ?  354 ILE R CG1 1 
ATOM   1594 C CG2 . ILE A 1 369 ? 122.361 167.989 135.656 1.00 74.39  ?  354 ILE R CG2 1 
ATOM   1595 C CD1 . ILE A 1 369 ? 122.853 167.220 132.866 1.00 74.39  ?  354 ILE R CD1 1 
ATOM   1596 N N   . CYS A 1 370 ? 125.081 165.338 138.212 1.00 75.21  ?  355 CYS R N   1 
ATOM   1597 C CA  . CYS A 1 370 ? 124.848 164.712 139.511 1.00 75.21  ?  355 CYS R CA  1 
ATOM   1598 C C   . CYS A 1 370 ? 126.076 164.810 140.405 1.00 75.21  ?  355 CYS R C   1 
ATOM   1599 O O   . CYS A 1 370 ? 126.039 164.406 141.571 1.00 75.21  ?  355 CYS R O   1 
ATOM   1600 C CB  . CYS A 1 370 ? 124.434 163.249 139.345 1.00 75.21  ?  355 CYS R CB  1 
ATOM   1601 S SG  . CYS A 1 370 ? 122.788 162.988 138.640 1.00 75.21  ?  355 CYS R SG  1 
ATOM   1602 N N   . TRP A 1 371 ? 127.172 165.344 139.865 1.00 74.03  ?  356 TRP R N   1 
ATOM   1603 C CA  . TRP A 1 371 ? 128.372 165.579 140.658 1.00 74.03  ?  356 TRP R CA  1 
ATOM   1604 C C   . TRP A 1 371 ? 128.951 166.952 140.361 1.00 74.03  ?  356 TRP R C   1 
ATOM   1605 O O   . TRP A 1 371 ? 130.123 167.210 140.654 1.00 74.03  ?  356 TRP R O   1 
ATOM   1606 C CB  . TRP A 1 371 ? 129.430 164.505 140.395 1.00 74.03  ?  356 TRP R CB  1 
ATOM   1607 C CG  . TRP A 1 371 ? 129.021 163.143 140.841 1.00 74.03  ?  356 TRP R CG  1 
ATOM   1608 C CD1 . TRP A 1 371 ? 128.483 162.160 140.069 1.00 74.03  ?  356 TRP R CD1 1 
ATOM   1609 C CD2 . TRP A 1 371 ? 129.116 162.608 142.163 1.00 74.03  ?  356 TRP R CD2 1 
ATOM   1610 N NE1 . TRP A 1 371 ? 128.236 161.044 140.827 1.00 74.03  ?  356 TRP R NE1 1 
ATOM   1611 C CE2 . TRP A 1 371 ? 128.617 161.294 142.118 1.00 74.03  ?  356 TRP R CE2 1 
ATOM   1612 C CE3 . TRP A 1 371 ? 129.577 163.112 143.382 1.00 74.03  ?  356 TRP R CE3 1 
ATOM   1613 C CZ2 . TRP A 1 371 ? 128.562 160.478 143.242 1.00 74.03  ?  356 TRP R CZ2 1 
ATOM   1614 C CZ3 . TRP A 1 371 ? 129.523 162.302 144.496 1.00 74.03  ?  356 TRP R CZ3 1 
ATOM   1615 C CH2 . TRP A 1 371 ? 129.019 161.000 144.419 1.00 74.03  ?  356 TRP R CH2 1 
ATOM   1616 N N   . GLY A 1 372 ? 128.153 167.825 139.763 1.00 71.45  ?  357 GLY R N   1 
ATOM   1617 C CA  . GLY A 1 372 ? 128.577 169.152 139.387 1.00 71.45  ?  357 GLY R CA  1 
ATOM   1618 C C   . GLY A 1 372 ? 127.870 170.309 140.076 1.00 71.45  ?  357 GLY R C   1 
ATOM   1619 O O   . GLY A 1 372 ? 128.501 171.332 140.357 1.00 71.45  ?  357 GLY R O   1 
ATOM   1620 N N   . PRO A 1 373 ? 126.551 170.209 140.358 1.00 73.01  ?  358 PRO R N   1 
ATOM   1621 C CA  . PRO A 1 373 ? 125.960 171.198 141.268 1.00 73.01  ?  358 PRO R CA  1 
ATOM   1622 C C   . PRO A 1 373 ? 126.398 171.050 142.719 1.00 73.01  ?  358 PRO R C   1 
ATOM   1623 O O   . PRO A 1 373 ? 126.681 172.059 143.372 1.00 73.01  ?  358 PRO R O   1 
ATOM   1624 C CB  . PRO A 1 373 ? 124.453 170.964 141.107 1.00 73.01  ?  358 PRO R CB  1 
ATOM   1625 C CG  . PRO A 1 373 ? 124.308 170.450 139.756 1.00 73.01  ?  358 PRO R CG  1 
ATOM   1626 C CD  . PRO A 1 373 ? 125.499 169.585 139.528 1.00 73.01  ?  358 PRO R CD  1 
ATOM   1627 N N   . LEU A 1 374 ? 126.461 169.825 143.247 1.00 74.82  ?  359 LEU R N   1 
ATOM   1628 C CA  . LEU A 1 374 ? 126.747 169.671 144.671 1.00 74.82  ?  359 LEU R CA  1 
ATOM   1629 C C   . LEU A 1 374 ? 128.240 169.811 144.956 1.00 74.82  ?  359 LEU R C   1 
ATOM   1630 O O   . LEU A 1 374 ? 128.621 170.189 146.067 1.00 74.82  ?  359 LEU R O   1 
ATOM   1631 C CB  . LEU A 1 374 ? 126.195 168.343 145.204 1.00 74.82  ?  359 LEU R CB  1 
ATOM   1632 C CG  . LEU A 1 374 ? 126.763 166.960 144.889 1.00 74.82  ?  359 LEU R CG  1 
ATOM   1633 C CD1 . LEU A 1 374 ? 127.761 166.518 145.950 1.00 74.82  ?  359 LEU R CD1 1 
ATOM   1634 C CD2 . LEU A 1 374 ? 125.642 165.946 144.766 1.00 74.82  ?  359 LEU R CD2 1 
ATOM   1635 N N   . LEU A 1 375 ? 129.099 169.516 143.979 1.00 72.97  ?  360 LEU R N   1 
ATOM   1636 C CA  . LEU A 1 375 ? 130.520 169.810 144.140 1.00 72.97  ?  360 LEU R CA  1 
ATOM   1637 C C   . LEU A 1 375 ? 130.862 171.259 143.833 1.00 72.97  ?  360 LEU R C   1 
ATOM   1638 O O   . LEU A 1 375 ? 132.041 171.606 143.762 1.00 72.97  ?  360 LEU R O   1 
ATOM   1639 C CB  . LEU A 1 375 ? 131.397 168.911 143.268 1.00 72.97  ?  360 LEU R CB  1 
ATOM   1640 C CG  . LEU A 1 375 ? 131.912 167.597 143.850 1.00 72.97  ?  360 LEU R CG  1 
ATOM   1641 C CD1 . LEU A 1 375 ? 130.853 166.533 143.870 1.00 72.97  ?  360 LEU R CD1 1 
ATOM   1642 C CD2 . LEU A 1 375 ? 133.111 167.134 143.064 1.00 72.97  ?  360 LEU R CD2 1 
ATOM   1643 N N   . ALA A 1 376 ? 129.862 172.110 143.622 1.00 76.12  ?  361 ALA R N   1 
ATOM   1644 C CA  . ALA A 1 376 ? 130.099 173.538 143.454 1.00 76.12  ?  361 ALA R CA  1 
ATOM   1645 C C   . ALA A 1 376 ? 129.721 174.310 144.708 1.00 76.12  ?  361 ALA R C   1 
ATOM   1646 O O   . ALA A 1 376 ? 130.426 175.252 145.083 1.00 76.12  ?  361 ALA R O   1 
ATOM   1647 C CB  . ALA A 1 376 ? 129.331 174.065 142.237 1.00 76.12  ?  361 ALA R CB  1 
ATOM   1648 N N   . ILE A 1 377 ? 128.623 173.937 145.364 1.00 75.78  ?  362 ILE R N   1 
ATOM   1649 C CA  . ILE A 1 377 ? 128.176 174.566 146.601 1.00 75.78  ?  362 ILE R CA  1 
ATOM   1650 C C   . ILE A 1 377 ? 129.173 174.248 147.709 1.00 75.78  ?  362 ILE R C   1 
ATOM   1651 O O   . ILE A 1 377 ? 129.507 175.113 148.527 1.00 75.78  ?  362 ILE R O   1 
ATOM   1652 C CB  . ILE A 1 377 ? 126.747 174.106 146.953 1.00 75.78  ?  362 ILE R CB  1 
ATOM   1653 C CG1 . ILE A 1 377 ? 125.786 174.531 145.846 1.00 75.78  ?  362 ILE R CG1 1 
ATOM   1654 C CG2 . ILE A 1 377 ? 126.279 174.696 148.267 1.00 75.78  ?  362 ILE R CG2 1 
ATOM   1655 C CD1 . ILE A 1 377 ? 124.420 173.937 145.972 1.00 75.78  ?  362 ILE R CD1 1 
ATOM   1656 N N   . MET A 1 378 ? 129.707 173.025 147.704 1.00 75.72  ?  363 MET R N   1 
ATOM   1657 C CA  . MET A 1 378 ? 130.682 172.601 148.704 1.00 75.72  ?  363 MET R CA  1 
ATOM   1658 C C   . MET A 1 378 ? 132.032 173.289 148.532 1.00 75.72  ?  363 MET R C   1 
ATOM   1659 O O   . MET A 1 378 ? 132.868 173.249 149.439 1.00 75.72  ?  363 MET R O   1 
ATOM   1660 C CB  . MET A 1 378 ? 130.866 171.083 148.656 1.00 75.72  ?  363 MET R CB  1 
ATOM   1661 C CG  . MET A 1 378 ? 129.684 170.293 149.177 1.00 75.72  ?  363 MET R CG  1 
ATOM   1662 S SD  . MET A 1 378 ? 129.877 168.521 148.924 1.00 75.72  ?  363 MET R SD  1 
ATOM   1663 C CE  . MET A 1 378 ? 131.218 168.166 150.046 1.00 75.72  ?  363 MET R CE  1 
ATOM   1664 N N   . VAL A 1 379 ? 132.259 173.920 147.383 1.00 76.77  ?  364 VAL R N   1 
ATOM   1665 C CA  . VAL A 1 379 ? 133.421 174.778 147.182 1.00 76.77  ?  364 VAL R CA  1 
ATOM   1666 C C   . VAL A 1 379 ? 133.163 176.205 147.643 1.00 76.77  ?  364 VAL R C   1 
ATOM   1667 O O   . VAL A 1 379 ? 134.077 176.834 148.202 1.00 76.77  ?  364 VAL R O   1 
ATOM   1668 C CB  . VAL A 1 379 ? 133.885 174.749 145.705 1.00 76.77  ?  364 VAL R CB  1 
ATOM   1669 C CG1 . VAL A 1 379 ? 135.050 175.687 145.428 1.00 76.77  ?  364 VAL R CG1 1 
ATOM   1670 C CG2 . VAL A 1 379 ? 134.303 173.350 145.333 1.00 76.77  ?  364 VAL R CG2 1 
ATOM   1671 N N   . TYR A 1 380 ? 131.920 176.686 147.570 1.00 77.99  ?  365 TYR R N   1 
ATOM   1672 C CA  . TYR A 1 380 ? 131.551 178.044 147.959 1.00 77.99  ?  365 TYR R CA  1 
ATOM   1673 C C   . TYR A 1 380 ? 131.729 178.318 149.462 1.00 77.99  ?  365 TYR R C   1 
ATOM   1674 O O   . TYR A 1 380 ? 131.726 179.483 149.873 1.00 77.99  ?  365 TYR R O   1 
ATOM   1675 C CB  . TYR A 1 380 ? 130.104 178.318 147.526 1.00 77.99  ?  365 TYR R CB  1 
ATOM   1676 C CG  . TYR A 1 380 ? 129.659 179.754 147.677 1.00 77.99  ?  365 TYR R CG  1 
ATOM   1677 C CD1 . TYR A 1 380 ? 130.125 180.736 146.816 1.00 77.99  ?  365 TYR R CD1 1 
ATOM   1678 C CD2 . TYR A 1 380 ? 128.779 180.127 148.678 1.00 77.99  ?  365 TYR R CD2 1 
ATOM   1679 C CE1 . TYR A 1 380 ? 129.731 182.049 146.949 1.00 77.99  ?  365 TYR R CE1 1 
ATOM   1680 C CE2 . TYR A 1 380 ? 128.377 181.439 148.818 1.00 77.99  ?  365 TYR R CE2 1 
ATOM   1681 C CZ  . TYR A 1 380 ? 128.858 182.394 147.950 1.00 77.99  ?  365 TYR R CZ  1 
ATOM   1682 O OH  . TYR A 1 380 ? 128.466 183.703 148.080 1.00 77.99  ?  365 TYR R OH  1 
ATOM   1683 N N   . ASP A 1 381 ? 131.943 177.288 150.281 1.00 79.68  ?  366 ASP R N   1 
ATOM   1684 C CA  . ASP A 1 381 ? 132.265 177.485 151.688 1.00 79.68  ?  366 ASP R CA  1 
ATOM   1685 C C   . ASP A 1 381 ? 133.731 177.859 151.858 1.00 79.68  ?  366 ASP R C   1 
ATOM   1686 O O   . ASP A 1 381 ? 134.057 178.835 152.541 1.00 79.68  ?  366 ASP R O   1 
ATOM   1687 C CB  . ASP A 1 381 ? 131.950 176.226 152.492 1.00 79.68  ?  366 ASP R CB  1 
ATOM   1688 C CG  . ASP A 1 381 ? 130.471 175.949 152.572 1.00 79.68  ?  366 ASP R CG  1 
ATOM   1689 O OD1 . ASP A 1 381 ? 129.684 176.917 152.516 1.00 79.68  ?  366 ASP R OD1 1 
ATOM   1690 O OD2 . ASP A 1 381 ? 130.092 174.766 152.689 1.00 79.68  -1 366 ASP R OD2 1 
ATOM   1691 N N   . VAL A 1 382 ? 134.619 177.079 151.246 1.00 78.53  ?  367 VAL R N   1 
ATOM   1692 C CA  . VAL A 1 382 ? 136.057 177.280 151.365 1.00 78.53  ?  367 VAL R CA  1 
ATOM   1693 C C   . VAL A 1 382 ? 136.464 178.511 150.560 1.00 78.53  ?  367 VAL R C   1 
ATOM   1694 O O   . VAL A 1 382 ? 137.357 179.267 150.964 1.00 78.53  ?  367 VAL R O   1 
ATOM   1695 C CB  . VAL A 1 382 ? 136.815 176.022 150.898 1.00 78.53  ?  367 VAL R CB  1 
ATOM   1696 C CG1 . VAL A 1 382 ? 138.317 176.172 151.088 1.00 78.53  ?  367 VAL R CG1 1 
ATOM   1697 C CG2 . VAL A 1 382 ? 136.302 174.796 151.622 1.00 78.53  ?  367 VAL R CG2 1 
ATOM   1698 N N   . PHE A 1 383 ? 135.780 178.750 149.439 1.00 79.19  ?  368 PHE R N   1 
ATOM   1699 C CA  . PHE A 1 383 ? 136.180 179.775 148.480 1.00 79.19  ?  368 PHE R CA  1 
ATOM   1700 C C   . PHE A 1 383 ? 135.564 181.138 148.763 1.00 79.19  ?  368 PHE R C   1 
ATOM   1701 O O   . PHE A 1 383 ? 135.438 181.951 147.841 1.00 79.19  ?  368 PHE R O   1 
ATOM   1702 C CB  . PHE A 1 383 ? 135.829 179.342 147.055 1.00 79.19  ?  368 PHE R CB  1 
ATOM   1703 N N   . GLY A 1 384 ? 135.178 181.409 150.004 1.00 77.17  ?  369 GLY R N   1 
ATOM   1704 C CA  . GLY A 1 384 ? 134.721 182.737 150.353 1.00 77.17  ?  369 GLY R CA  1 
ATOM   1705 C C   . GLY A 1 384 ? 133.748 182.777 151.509 1.00 77.17  ?  369 GLY R C   1 
ATOM   1706 O O   . GLY A 1 384 ? 133.834 181.973 152.441 1.00 77.17  ?  369 GLY R O   1 
ATOM   1707 N N   . LYS A 1 385 ? 132.810 183.714 151.447 1.00 82.54  ?  370 LYS R N   1 
ATOM   1708 C CA  . LYS A 1 385 ? 131.831 183.918 152.501 1.00 82.54  ?  370 LYS R CA  1 
ATOM   1709 C C   . LYS A 1 385 ? 130.618 183.021 152.286 1.00 82.54  ?  370 LYS R C   1 
ATOM   1710 O O   . LYS A 1 385 ? 130.368 182.521 151.188 1.00 82.54  ?  370 LYS R O   1 
ATOM   1711 C CB  . LYS A 1 385 ? 131.398 185.385 152.549 1.00 82.54  ?  370 LYS R CB  1 
ATOM   1712 N N   . MET A 1 386 ? 129.864 182.819 153.362 1.00 82.27  ?  371 MET R N   1 
ATOM   1713 C CA  . MET A 1 386 ? 128.625 182.064 153.314 1.00 82.27  ?  371 MET R CA  1 
ATOM   1714 C C   . MET A 1 386 ? 127.480 182.984 153.699 1.00 82.27  ?  371 MET R C   1 
ATOM   1715 O O   . MET A 1 386 ? 127.686 184.070 154.245 1.00 82.27  ?  371 MET R O   1 
ATOM   1716 C CB  . MET A 1 386 ? 128.662 180.845 154.240 1.00 82.27  ?  371 MET R CB  1 
ATOM   1717 N N   . ASN A 1 387 ? 126.263 182.529 153.412 1.00 86.33  ?  372 ASN R N   1 
ATOM   1718 C CA  . ASN A 1 387 ? 125.071 183.330 153.658 1.00 86.33  ?  372 ASN R CA  1 
ATOM   1719 C C   . ASN A 1 387 ? 123.910 182.432 154.061 1.00 86.33  ?  372 ASN R C   1 
ATOM   1720 O O   . ASN A 1 387 ? 124.117 181.270 154.424 1.00 86.33  ?  372 ASN R O   1 
ATOM   1721 C CB  . ASN A 1 387 ? 124.710 184.161 152.424 1.00 86.33  ?  372 ASN R CB  1 
ATOM   1722 N N   . LYS A 1 388 ? 122.686 182.956 154.005 1.00 80.15  ?  373 LYS R N   1 
ATOM   1723 C CA  . LYS A 1 388 ? 121.523 182.239 154.520 1.00 80.15  ?  373 LYS R CA  1 
ATOM   1724 C C   . LYS A 1 388 ? 120.851 181.409 153.434 1.00 80.15  ?  373 LYS R C   1 
ATOM   1725 O O   . LYS A 1 388 ? 120.508 180.253 153.686 1.00 80.15  ?  373 LYS R O   1 
ATOM   1726 C CB  . LYS A 1 388 ? 120.541 183.226 155.152 1.00 80.15  ?  373 LYS R CB  1 
ATOM   1727 N N   . LEU A 1 389 ? 120.667 181.948 152.230 1.00 80.22  ?  374 LEU R N   1 
ATOM   1728 C CA  . LEU A 1 389 ? 119.828 181.306 151.221 1.00 80.22  ?  374 LEU R CA  1 
ATOM   1729 C C   . LEU A 1 389 ? 120.522 180.162 150.488 1.00 80.22  ?  374 LEU R C   1 
ATOM   1730 O O   . LEU A 1 389 ? 119.928 179.553 149.592 1.00 80.22  ?  374 LEU R O   1 
ATOM   1731 C CB  . LEU A 1 389 ? 119.338 182.342 150.204 1.00 80.22  ?  374 LEU R CB  1 
ATOM   1732 N N   . ILE A 1 390 ? 121.769 179.862 150.845 1.00 79.79  ?  375 ILE R N   1 
ATOM   1733 C CA  . ILE A 1 390 ? 122.495 178.762 150.223 1.00 79.79  ?  375 ILE R CA  1 
ATOM   1734 C C   . ILE A 1 390 ? 122.369 177.566 151.166 1.00 79.79  ?  375 ILE R C   1 
ATOM   1735 O O   . ILE A 1 390 ? 122.500 176.407 150.755 1.00 79.79  ?  375 ILE R O   1 
ATOM   1736 C CB  . ILE A 1 390 ? 123.962 179.153 149.920 1.00 79.79  ?  375 ILE R CB  1 
ATOM   1737 C CG1 . ILE A 1 390 ? 124.027 180.355 148.970 1.00 79.79  ?  375 ILE R CG1 1 
ATOM   1738 C CG2 . ILE A 1 390 ? 124.723 178.051 149.204 1.00 79.79  ?  375 ILE R CG2 1 
ATOM   1739 C CD1 . ILE A 1 390 ? 124.245 181.707 149.629 1.00 79.79  ?  375 ILE R CD1 1 
ATOM   1740 N N   . LYS A 1 391 ? 122.013 177.828 152.424 1.00 77.72  ?  376 LYS R N   1 
ATOM   1741 C CA  . LYS A 1 391 ? 121.736 176.748 153.359 1.00 77.72  ?  376 LYS R CA  1 
ATOM   1742 C C   . LYS A 1 391 ? 120.392 176.077 153.131 1.00 77.72  ?  376 LYS R C   1 
ATOM   1743 O O   . LYS A 1 391 ? 120.175 174.979 153.650 1.00 77.72  ?  376 LYS R O   1 
ATOM   1744 C CB  . LYS A 1 391 ? 121.779 177.249 154.810 1.00 77.72  ?  376 LYS R CB  1 
ATOM   1745 C CG  . LYS A 1 391 ? 123.160 177.563 155.347 1.00 77.72  ?  376 LYS R CG  1 
ATOM   1746 C CD  . LYS A 1 391 ? 123.070 177.951 156.810 1.00 77.72  ?  376 LYS R CD  1 
ATOM   1747 C CE  . LYS A 1 391 ? 124.426 178.277 157.388 1.00 77.72  ?  376 LYS R CE  1 
ATOM   1748 N NZ  . LYS A 1 391 ? 124.331 178.639 158.826 1.00 77.72  ?  376 LYS R NZ  1 
ATOM   1749 N N   . THR A 1 392 ? 119.489 176.706 152.382 1.00 76.64  ?  377 THR R N   1 
ATOM   1750 C CA  . THR A 1 392 ? 118.183 176.130 152.101 1.00 76.64  ?  377 THR R CA  1 
ATOM   1751 C C   . THR A 1 392 ? 118.127 175.411 150.765 1.00 76.64  ?  377 THR R C   1 
ATOM   1752 O O   . THR A 1 392 ? 117.149 174.707 150.505 1.00 76.64  ?  377 THR R O   1 
ATOM   1753 C CB  . THR A 1 392 ? 117.100 177.214 152.128 1.00 76.64  ?  377 THR R CB  1 
ATOM   1754 N N   . VAL A 1 393 ? 119.139 175.566 149.915 1.00 77.54  ?  378 VAL R N   1 
ATOM   1755 C CA  . VAL A 1 393 ? 119.156 174.926 148.607 1.00 77.54  ?  378 VAL R CA  1 
ATOM   1756 C C   . VAL A 1 393 ? 120.174 173.793 148.558 1.00 77.54  ?  378 VAL R C   1 
ATOM   1757 O O   . VAL A 1 393 ? 120.200 173.021 147.595 1.00 77.54  ?  378 VAL R O   1 
ATOM   1758 C CB  . VAL A 1 393 ? 119.407 175.959 147.492 1.00 77.54  ?  378 VAL R CB  1 
ATOM   1759 C CG1 . VAL A 1 393 ? 120.883 176.317 147.393 1.00 77.54  ?  378 VAL R CG1 1 
ATOM   1760 C CG2 . VAL A 1 393 ? 118.800 175.523 146.151 1.00 77.54  ?  378 VAL R CG2 1 
ATOM   1761 N N   . PHE A 1 394 ? 120.992 173.646 149.597 1.00 76.27  ?  379 PHE R N   1 
ATOM   1762 C CA  . PHE A 1 394 ? 121.851 172.481 149.729 1.00 76.27  ?  379 PHE R CA  1 
ATOM   1763 C C   . PHE A 1 394 ? 121.071 171.254 150.175 1.00 76.27  ?  379 PHE R C   1 
ATOM   1764 O O   . PHE A 1 394 ? 121.534 170.129 149.963 1.00 76.27  ?  379 PHE R O   1 
ATOM   1765 C CB  . PHE A 1 394 ? 122.992 172.778 150.718 1.00 76.27  ?  379 PHE R CB  1 
ATOM   1766 C CG  . PHE A 1 394 ? 124.045 171.699 150.795 1.00 76.27  ?  379 PHE R CG  1 
ATOM   1767 C CD1 . PHE A 1 394 ? 124.977 171.552 149.782 1.00 76.27  ?  379 PHE R CD1 1 
ATOM   1768 C CD2 . PHE A 1 394 ? 124.111 170.847 151.886 1.00 76.27  ?  379 PHE R CD2 1 
ATOM   1769 C CE1 . PHE A 1 394 ? 125.946 170.567 149.849 1.00 76.27  ?  379 PHE R CE1 1 
ATOM   1770 C CE2 . PHE A 1 394 ? 125.080 169.860 151.957 1.00 76.27  ?  379 PHE R CE2 1 
ATOM   1771 C CZ  . PHE A 1 394 ? 125.995 169.723 150.937 1.00 76.27  ?  379 PHE R CZ  1 
ATOM   1772 N N   . ALA A 1 395 ? 119.887 171.444 150.752 1.00 79.28  ?  380 ALA R N   1 
ATOM   1773 C CA  . ALA A 1 395 ? 119.028 170.349 151.176 1.00 79.28  ?  380 ALA R CA  1 
ATOM   1774 C C   . ALA A 1 395 ? 118.189 169.785 150.037 1.00 79.28  ?  380 ALA R C   1 
ATOM   1775 O O   . ALA A 1 395 ? 117.564 168.735 150.206 1.00 79.28  ?  380 ALA R O   1 
ATOM   1776 C CB  . ALA A 1 395 ? 118.119 170.809 152.315 1.00 79.28  ?  380 ALA R CB  1 
ATOM   1777 N N   . PHE A 1 396 ? 118.160 170.457 148.887 1.00 82.18  ?  381 PHE R N   1 
ATOM   1778 C CA  . PHE A 1 396 ? 117.616 169.867 147.670 1.00 82.18  ?  381 PHE R CA  1 
ATOM   1779 C C   . PHE A 1 396 ? 118.691 169.496 146.666 1.00 82.18  ?  381 PHE R C   1 
ATOM   1780 O O   . PHE A 1 396 ? 118.401 168.734 145.741 1.00 82.18  ?  381 PHE R O   1 
ATOM   1781 C CB  . PHE A 1 396 ? 116.620 170.815 146.988 1.00 82.18  ?  381 PHE R CB  1 
ATOM   1782 C CG  . PHE A 1 396 ? 115.325 170.974 147.721 1.00 82.18  ?  381 PHE R CG  1 
ATOM   1783 C CD1 . PHE A 1 396 ? 114.342 170.002 147.630 1.00 82.18  ?  381 PHE R CD1 1 
ATOM   1784 C CD2 . PHE A 1 396 ? 115.079 172.106 148.478 1.00 82.18  ?  381 PHE R CD2 1 
ATOM   1785 C CE1 . PHE A 1 396 ? 113.142 170.148 148.296 1.00 82.18  ?  381 PHE R CE1 1 
ATOM   1786 C CE2 . PHE A 1 396 ? 113.884 172.259 149.147 1.00 82.18  ?  381 PHE R CE2 1 
ATOM   1787 C CZ  . PHE A 1 396 ? 112.912 171.278 149.055 1.00 82.18  ?  381 PHE R CZ  1 
ATOM   1788 N N   . CYS A 1 397 ? 119.917 169.996 146.817 1.00 80.47  ?  382 CYS R N   1 
ATOM   1789 C CA  . CYS A 1 397 ? 121.046 169.620 145.982 1.00 80.47  ?  382 CYS R CA  1 
ATOM   1790 C C   . CYS A 1 397 ? 121.805 168.440 146.583 1.00 80.47  ?  382 CYS R C   1 
ATOM   1791 O O   . CYS A 1 397 ? 122.877 168.065 146.099 1.00 80.47  ?  382 CYS R O   1 
ATOM   1792 C CB  . CYS A 1 397 ? 121.956 170.836 145.791 1.00 80.47  ?  382 CYS R CB  1 
ATOM   1793 S SG  . CYS A 1 397 ? 123.204 170.747 144.493 1.00 80.47  ?  382 CYS R SG  1 
ATOM   1794 N N   . SER A 1 398 ? 121.242 167.829 147.621 1.00 83.24  ?  383 SER R N   1 
ATOM   1795 C CA  . SER A 1 398 ? 121.774 166.608 148.199 1.00 83.24  ?  383 SER R CA  1 
ATOM   1796 C C   . SER A 1 398 ? 120.932 165.385 147.888 1.00 83.24  ?  383 SER R C   1 
ATOM   1797 O O   . SER A 1 398 ? 121.433 164.266 148.041 1.00 83.24  ?  383 SER R O   1 
ATOM   1798 C CB  . SER A 1 398 ? 121.904 166.748 149.722 1.00 83.24  ?  383 SER R CB  1 
ATOM   1799 O OG  . SER A 1 398 ? 122.396 165.555 150.301 1.00 83.24  ?  383 SER R OG  1 
ATOM   1800 N N   . MET A 1 399 ? 119.681 165.553 147.453 1.00 82.84  ?  384 MET R N   1 
ATOM   1801 C CA  . MET A 1 399 ? 118.875 164.444 146.960 1.00 82.84  ?  384 MET R CA  1 
ATOM   1802 C C   . MET A 1 399 ? 119.204 164.053 145.528 1.00 82.84  ?  384 MET R C   1 
ATOM   1803 O O   . MET A 1 399 ? 118.539 163.163 144.988 1.00 82.84  ?  384 MET R O   1 
ATOM   1804 C CB  . MET A 1 399 ? 117.388 164.776 147.071 1.00 82.84  ?  384 MET R CB  1 
ATOM   1805 C CG  . MET A 1 399 ? 116.814 164.609 148.457 1.00 82.84  ?  384 MET R CG  1 
ATOM   1806 S SD  . MET A 1 399 ? 116.811 162.862 148.912 1.00 82.84  ?  384 MET R SD  1 
ATOM   1807 C CE  . MET A 1 399 ? 116.208 162.920 150.589 1.00 82.84  ?  384 MET R CE  1 
ATOM   1808 N N   . LEU A 1 400 ? 120.200 164.681 144.898 1.00 82.07  ?  385 LEU R N   1 
ATOM   1809 C CA  . LEU A 1 400 ? 120.657 164.212 143.596 1.00 82.07  ?  385 LEU R CA  1 
ATOM   1810 C C   . LEU A 1 400 ? 121.421 162.901 143.712 1.00 82.07  ?  385 LEU R C   1 
ATOM   1811 O O   . LEU A 1 400 ? 121.537 162.166 142.726 1.00 82.07  ?  385 LEU R O   1 
ATOM   1812 C CB  . LEU A 1 400 ? 121.529 165.271 142.925 1.00 82.07  ?  385 LEU R CB  1 
ATOM   1813 C CG  . LEU A 1 400 ? 120.843 166.566 142.493 1.00 82.07  ?  385 LEU R CG  1 
ATOM   1814 C CD1 . LEU A 1 400 ? 121.862 167.546 141.943 1.00 82.07  ?  385 LEU R CD1 1 
ATOM   1815 C CD2 . LEU A 1 400 ? 119.763 166.283 141.470 1.00 82.07  ?  385 LEU R CD2 1 
ATOM   1816 N N   . CYS A 1 401 ? 121.949 162.592 144.898 1.00 83.73  ?  386 CYS R N   1 
ATOM   1817 C CA  . CYS A 1 401 ? 122.639 161.328 145.114 1.00 83.73  ?  386 CYS R CA  1 
ATOM   1818 C C   . CYS A 1 401 ? 121.693 160.135 145.115 1.00 83.73  ?  386 CYS R C   1 
ATOM   1819 O O   . CYS A 1 401 ? 122.141 159.014 144.854 1.00 83.73  ?  386 CYS R O   1 
ATOM   1820 C CB  . CYS A 1 401 ? 123.418 161.376 146.427 1.00 83.73  ?  386 CYS R CB  1 
ATOM   1821 S SG  . CYS A 1 401 ? 124.776 162.570 146.434 1.00 83.73  ?  386 CYS R SG  1 
ATOM   1822 N N   . LEU A 1 402 ? 120.410 160.341 145.400 1.00 81.52  ?  387 LEU R N   1 
ATOM   1823 C CA  . LEU A 1 402 ? 119.397 159.315 145.201 1.00 81.52  ?  387 LEU R CA  1 
ATOM   1824 C C   . LEU A 1 402 ? 118.799 159.353 143.807 1.00 81.52  ?  387 LEU R C   1 
ATOM   1825 O O   . LEU A 1 402 ? 117.908 158.554 143.505 1.00 81.52  ?  387 LEU R O   1 
ATOM   1826 C CB  . LEU A 1 402 ? 118.285 159.436 146.242 1.00 81.52  ?  387 LEU R CB  1 
ATOM   1827 C CG  . LEU A 1 402 ? 118.433 158.596 147.508 1.00 81.52  ?  387 LEU R CG  1 
ATOM   1828 C CD1 . LEU A 1 402 ? 119.565 159.074 148.370 1.00 81.52  ?  387 LEU R CD1 1 
ATOM   1829 C CD2 . LEU A 1 402 ? 117.135 158.627 148.284 1.00 81.52  ?  387 LEU R CD2 1 
ATOM   1830 N N   . LEU A 1 403 ? 119.254 160.271 142.962 1.00 79.66  ?  388 LEU R N   1 
ATOM   1831 C CA  . LEU A 1 403 ? 118.970 160.203 141.538 1.00 79.66  ?  388 LEU R CA  1 
ATOM   1832 C C   . LEU A 1 403 ? 120.093 159.529 140.770 1.00 79.66  ?  388 LEU R C   1 
ATOM   1833 O O   . LEU A 1 403 ? 119.827 158.810 139.803 1.00 79.66  ?  388 LEU R O   1 
ATOM   1834 C CB  . LEU A 1 403 ? 118.725 161.608 140.980 1.00 79.66  ?  388 LEU R CB  1 
ATOM   1835 C CG  . LEU A 1 403 ? 118.260 161.701 139.531 1.00 79.66  ?  388 LEU R CG  1 
ATOM   1836 C CD1 . LEU A 1 403 ? 116.924 161.001 139.377 1.00 79.66  ?  388 LEU R CD1 1 
ATOM   1837 C CD2 . LEU A 1 403 ? 118.164 163.150 139.097 1.00 79.66  ?  388 LEU R CD2 1 
ATOM   1838 N N   . ASN A 1 404 ? 121.340 159.713 141.204 1.00 79.52  ?  389 ASN R N   1 
ATOM   1839 C CA  . ASN A 1 404 ? 122.454 158.955 140.653 1.00 79.52  ?  389 ASN R CA  1 
ATOM   1840 C C   . ASN A 1 404 ? 122.694 157.706 141.494 1.00 79.52  ?  389 ASN R C   1 
ATOM   1841 O O   . ASN A 1 404 ? 123.837 157.392 141.840 1.00 79.52  ?  389 ASN R O   1 
ATOM   1842 C CB  . ASN A 1 404 ? 123.709 159.829 140.622 1.00 79.52  ?  389 ASN R CB  1 
ATOM   1843 C CG  . ASN A 1 404 ? 124.716 159.394 139.573 1.00 79.52  ?  389 ASN R CG  1 
ATOM   1844 O OD1 . ASN A 1 404 ? 125.648 160.133 139.265 1.00 79.52  ?  389 ASN R OD1 1 
ATOM   1845 N ND2 . ASN A 1 404 ? 124.528 158.209 139.009 1.00 79.52  ?  389 ASN R ND2 1 
ATOM   1846 N N   . SER A 1 405 ? 121.621 156.991 141.827 1.00 78.47  ?  390 SER R N   1 
ATOM   1847 C CA  . SER A 1 405 ? 121.693 155.643 142.371 1.00 78.47  ?  390 SER R CA  1 
ATOM   1848 C C   . SER A 1 405 ? 120.611 154.803 141.715 1.00 78.47  ?  390 SER R C   1 
ATOM   1849 O O   . SER A 1 405 ? 120.700 153.573 141.666 1.00 78.47  ?  390 SER R O   1 
ATOM   1850 C CB  . SER A 1 405 ? 121.527 155.649 143.889 1.00 78.47  ?  390 SER R CB  1 
ATOM   1851 O OG  . SER A 1 405 ? 121.539 154.329 144.396 1.00 78.47  ?  390 SER R OG  1 
ATOM   1852 N N   . THR A 1 406 ? 119.578 155.480 141.212 1.00 76.67  ?  391 THR R N   1 
ATOM   1853 C CA  . THR A 1 406 ? 118.469 154.820 140.540 1.00 76.67  ?  391 THR R CA  1 
ATOM   1854 C C   . THR A 1 406 ? 118.780 154.529 139.078 1.00 76.67  ?  391 THR R C   1 
ATOM   1855 O O   . THR A 1 406 ? 118.438 153.449 138.583 1.00 76.67  ?  391 THR R O   1 
ATOM   1856 C CB  . THR A 1 406 ? 117.217 155.697 140.656 1.00 76.67  ?  391 THR R CB  1 
ATOM   1857 O OG1 . THR A 1 406 ? 116.942 155.946 142.038 1.00 76.67  ?  391 THR R OG1 1 
ATOM   1858 C CG2 . THR A 1 406 ? 116.004 155.028 140.031 1.00 76.67  ?  391 THR R CG2 1 
ATOM   1859 N N   . VAL A 1 407 ? 119.455 155.450 138.390 1.00 76.40  ?  392 VAL R N   1 
ATOM   1860 C CA  . VAL A 1 407 ? 119.672 155.356 136.951 1.00 76.40  ?  392 VAL R CA  1 
ATOM   1861 C C   . VAL A 1 407 ? 120.878 154.488 136.624 1.00 76.40  ?  392 VAL R C   1 
ATOM   1862 O O   . VAL A 1 407 ? 121.072 154.109 135.465 1.00 76.40  ?  392 VAL R O   1 
ATOM   1863 C CB  . VAL A 1 407 ? 119.836 156.751 136.326 1.00 76.40  ?  392 VAL R CB  1 
ATOM   1864 C CG1 . VAL A 1 407 ? 118.561 157.556 136.484 1.00 76.40  ?  392 VAL R CG1 1 
ATOM   1865 C CG2 . VAL A 1 407 ? 121.001 157.467 136.965 1.00 76.40  ?  392 VAL R CG2 1 
ATOM   1866 N N   . ASN A 1 408 ? 121.710 154.189 137.624 1.00 75.80  ?  393 ASN R N   1 
ATOM   1867 C CA  . ASN A 1 408 ? 122.893 153.360 137.400 1.00 75.80  ?  393 ASN R CA  1 
ATOM   1868 C C   . ASN A 1 408 ? 122.576 151.921 136.974 1.00 75.80  ?  393 ASN R C   1 
ATOM   1869 O O   . ASN A 1 408 ? 123.303 151.392 136.127 1.00 75.80  ?  393 ASN R O   1 
ATOM   1870 C CB  . ASN A 1 408 ? 123.810 153.368 138.629 1.00 75.80  ?  393 ASN R CB  1 
ATOM   1871 C CG  . ASN A 1 408 ? 124.591 154.654 138.761 1.00 75.80  ?  393 ASN R CG  1 
ATOM   1872 O OD1 . ASN A 1 408 ? 125.073 155.203 137.772 1.00 75.80  ?  393 ASN R OD1 1 
ATOM   1873 N ND2 . ASN A 1 408 ? 124.739 155.133 139.987 1.00 75.80  ?  393 ASN R ND2 1 
ATOM   1874 N N   . PRO A 1 409 ? 121.530 151.226 137.500 1.00 75.31  ?  394 PRO R N   1 
ATOM   1875 C CA  . PRO A 1 409 ? 121.119 149.993 136.813 1.00 75.31  ?  394 PRO R CA  1 
ATOM   1876 C C   . PRO A 1 409 ? 120.104 150.215 135.700 1.00 75.31  ?  394 PRO R C   1 
ATOM   1877 O O   . PRO A 1 409 ? 119.142 149.452 135.582 1.00 75.31  ?  394 PRO R O   1 
ATOM   1878 C CB  . PRO A 1 409 ? 120.517 149.150 137.940 1.00 75.31  ?  394 PRO R CB  1 
ATOM   1879 C CG  . PRO A 1 409 ? 119.984 150.126 138.867 1.00 75.31  ?  394 PRO R CG  1 
ATOM   1880 C CD  . PRO A 1 409 ? 120.929 151.279 138.851 1.00 75.31  ?  394 PRO R CD  1 
ATOM   1881 N N   . ILE A 1 410 ? 120.298 151.248 134.879 1.00 75.64  ?  395 ILE R N   1 
ATOM   1882 C CA  . ILE A 1 410 ? 119.517 151.457 133.662 1.00 75.64  ?  395 ILE R CA  1 
ATOM   1883 C C   . ILE A 1 410 ? 120.546 151.712 132.563 1.00 75.64  ?  395 ILE R C   1 
ATOM   1884 O O   . ILE A 1 410 ? 120.255 151.616 131.365 1.00 75.64  ?  395 ILE R O   1 
ATOM   1885 C CB  . ILE A 1 410 ? 118.505 152.622 133.810 1.00 75.64  ?  395 ILE R CB  1 
ATOM   1886 C CG1 . ILE A 1 410 ? 117.565 152.402 134.994 1.00 75.64  ?  395 ILE R CG1 1 
ATOM   1887 C CG2 . ILE A 1 410 ? 117.572 152.742 132.612 1.00 75.64  ?  395 ILE R CG2 1 
ATOM   1888 C CD1 . ILE A 1 410 ? 116.702 153.597 135.321 1.00 75.64  ?  395 ILE R CD1 1 
ATOM   1889 N N   . ILE A 1 411 ? 121.790 151.955 132.968 1.00 73.27  ?  396 ILE R N   1 
ATOM   1890 C CA  . ILE A 1 411 ? 122.827 152.380 132.038 1.00 73.27  ?  396 ILE R CA  1 
ATOM   1891 C C   . ILE A 1 411 ? 123.932 151.329 131.996 1.00 73.27  ?  396 ILE R C   1 
ATOM   1892 O O   . ILE A 1 411 ? 124.537 151.087 130.944 1.00 73.27  ?  396 ILE R O   1 
ATOM   1893 C CB  . ILE A 1 411 ? 123.360 153.770 132.442 1.00 73.27  ?  396 ILE R CB  1 
ATOM   1894 C CG1 . ILE A 1 411 ? 122.244 154.806 132.356 1.00 73.27  ?  396 ILE R CG1 1 
ATOM   1895 C CG2 . ILE A 1 411 ? 124.489 154.231 131.558 1.00 73.27  ?  396 ILE R CG2 1 
ATOM   1896 C CD1 . ILE A 1 411 ? 122.619 156.138 132.947 1.00 73.27  ?  396 ILE R CD1 1 
ATOM   1897 N N   . TYR A 1 412 ? 124.152 150.633 133.111 1.00 69.21  ?  397 TYR R N   1 
ATOM   1898 C CA  . TYR A 1 412 ? 125.208 149.633 133.181 1.00 69.21  ?  397 TYR R CA  1 
ATOM   1899 C C   . TYR A 1 412 ? 124.717 148.197 133.157 1.00 69.21  ?  397 TYR R C   1 
ATOM   1900 O O   . TYR A 1 412 ? 125.464 147.322 132.711 1.00 69.21  ?  397 TYR R O   1 
ATOM   1901 C CB  . TYR A 1 412 ? 126.053 149.817 134.449 1.00 69.21  ?  397 TYR R CB  1 
ATOM   1902 C CG  . TYR A 1 412 ? 126.974 151.005 134.425 1.00 69.21  ?  397 TYR R CG  1 
ATOM   1903 C CD1 . TYR A 1 412 ? 127.272 151.658 133.241 1.00 69.21  ?  397 TYR R CD1 1 
ATOM   1904 C CD2 . TYR A 1 412 ? 127.555 151.468 135.591 1.00 69.21  ?  397 TYR R CD2 1 
ATOM   1905 C CE1 . TYR A 1 412 ? 128.119 152.746 133.224 1.00 69.21  ?  397 TYR R CE1 1 
ATOM   1906 C CE2 . TYR A 1 412 ? 128.398 152.549 135.580 1.00 69.21  ?  397 TYR R CE2 1 
ATOM   1907 C CZ  . TYR A 1 412 ? 128.678 153.185 134.400 1.00 69.21  ?  397 TYR R CZ  1 
ATOM   1908 O OH  . TYR A 1 412 ? 129.525 154.266 134.400 1.00 69.21  ?  397 TYR R OH  1 
ATOM   1909 N N   . ALA A 1 413 ? 123.497 147.924 133.622 1.00 73.16  ?  398 ALA R N   1 
ATOM   1910 C CA  . ALA A 1 413 ? 122.999 146.564 133.691 1.00 73.16  ?  398 ALA R CA  1 
ATOM   1911 C C   . ALA A 1 413 ? 122.063 146.363 132.514 1.00 73.16  ?  398 ALA R C   1 
ATOM   1912 O O   . ALA A 1 413 ? 122.065 145.281 131.907 1.00 73.16  ?  398 ALA R O   1 
ATOM   1913 C CB  . ALA A 1 413 ? 122.345 146.295 135.050 1.00 73.16  ?  398 ALA R CB  1 
ATOM   1914 N N   . LEU A 1 414 ? 121.238 147.342 132.157 1.00 77.65  ?  399 LEU R N   1 
ATOM   1915 C CA  . LEU A 1 414 ? 120.278 147.173 131.076 1.00 77.65  ?  399 LEU R CA  1 
ATOM   1916 C C   . LEU A 1 414 ? 120.968 147.176 129.715 1.00 77.65  ?  399 LEU R C   1 
ATOM   1917 O O   . LEU A 1 414 ? 120.622 146.377 128.840 1.00 77.65  ?  399 LEU R O   1 
ATOM   1918 C CB  . LEU A 1 414 ? 119.213 148.266 131.142 1.00 77.65  ?  399 LEU R CB  1 
ATOM   1919 C CG  . LEU A 1 414 ? 118.008 148.055 130.232 1.00 77.65  ?  399 LEU R CG  1 
ATOM   1920 C CD1 . LEU A 1 414 ? 117.256 146.813 130.678 1.00 77.65  ?  399 LEU R CD1 1 
ATOM   1921 C CD2 . LEU A 1 414 ? 117.101 149.271 130.239 1.00 77.65  ?  399 LEU R CD2 1 
ATOM   1922 N N   . ARG A 1 415 ? 121.950 148.057 129.525 1.00 80.10  ?  400 ARG R N   1 
ATOM   1923 C CA  . ARG A 1 415 ? 122.655 148.145 128.249 1.00 80.10  ?  400 ARG R CA  1 
ATOM   1924 C C   . ARG A 1 415 ? 123.675 147.028 128.081 1.00 80.10  ?  400 ARG R C   1 
ATOM   1925 O O   . ARG A 1 415 ? 124.883 147.284 128.064 1.00 80.10  ?  400 ARG R O   1 
ATOM   1926 C CB  . ARG A 1 415 ? 123.356 149.497 128.103 1.00 80.10  ?  400 ARG R CB  1 
ATOM   1927 C CG  . ARG A 1 415 ? 122.414 150.677 128.070 1.00 80.10  ?  400 ARG R CG  1 
ATOM   1928 C CD  . ARG A 1 415 ? 121.565 150.651 126.818 1.00 80.10  ?  400 ARG R CD  1 
ATOM   1929 N NE  . ARG A 1 415 ? 120.655 151.788 126.755 1.00 80.10  ?  400 ARG R NE  1 
ATOM   1930 C CZ  . ARG A 1 415 ? 119.722 151.940 125.823 1.00 80.10  ?  400 ARG R CZ  1 
ATOM   1931 N NH1 . ARG A 1 415 ? 118.933 153.004 125.839 1.00 80.10  ?  400 ARG R NH1 1 
ATOM   1932 N NH2 . ARG A 1 415 ? 119.576 151.023 124.877 1.00 80.10  ?  400 ARG R NH2 1 
ATOM   1933 N N   . SER A 1 416 ? 123.201 145.790 127.951 1.00 82.34  ?  401 SER R N   1 
ATOM   1934 C CA  . SER A 1 416 ? 124.064 144.651 127.678 1.00 82.34  ?  401 SER R CA  1 
ATOM   1935 C C   . SER A 1 416 ? 123.244 143.563 127.008 1.00 82.34  ?  401 SER R C   1 
ATOM   1936 O O   . SER A 1 416 ? 122.011 143.575 127.045 1.00 82.34  ?  401 SER R O   1 
ATOM   1937 C CB  . SER A 1 416 ? 124.727 144.109 128.949 1.00 82.34  ?  401 SER R CB  1 
ATOM   1938 O OG  . SER A 1 416 ? 125.660 145.036 129.474 1.00 82.34  ?  401 SER R OG  1 
ATOM   1939 N N   . LYS A 1 417 ? 123.950 142.616 126.388 1.00 79.47  ?  402 LYS R N   1 
ATOM   1940 C CA  . LYS A 1 417 ? 123.317 141.473 125.750 1.00 79.47  ?  402 LYS R CA  1 
ATOM   1941 C C   . LYS A 1 417 ? 123.410 140.197 126.570 1.00 79.47  ?  402 LYS R C   1 
ATOM   1942 O O   . LYS A 1 417 ? 122.700 139.235 126.264 1.00 79.47  ?  402 LYS R O   1 
ATOM   1943 C CB  . LYS A 1 417 ? 123.932 141.222 124.366 1.00 79.47  ?  402 LYS R CB  1 
ATOM   1944 N N   . ASP A 1 418 ? 124.261 140.162 127.594 1.00 79.28  ?  403 ASP R N   1 
ATOM   1945 C CA  . ASP A 1 418 ? 124.357 139.005 128.473 1.00 79.28  ?  403 ASP R CA  1 
ATOM   1946 C C   . ASP A 1 418 ? 123.393 139.103 129.651 1.00 79.28  ?  403 ASP R C   1 
ATOM   1947 O O   . ASP A 1 418 ? 122.692 138.135 129.961 1.00 79.28  ?  403 ASP R O   1 
ATOM   1948 C CB  . ASP A 1 418 ? 125.794 138.846 128.976 1.00 79.28  ?  403 ASP R CB  1 
ATOM   1949 C CG  . ASP A 1 418 ? 126.751 138.406 127.886 1.00 79.28  ?  403 ASP R CG  1 
ATOM   1950 O OD1 . ASP A 1 418 ? 126.312 137.703 126.954 1.00 79.28  ?  403 ASP R OD1 1 
ATOM   1951 O OD2 . ASP A 1 418 ? 127.944 138.762 127.962 1.00 79.28  -1 403 ASP R OD2 1 
ATOM   1952 N N   . LEU A 1 419 ? 123.340 140.262 130.313 1.00 79.24  ?  404 LEU R N   1 
ATOM   1953 C CA  . LEU A 1 419 ? 122.468 140.431 131.470 1.00 79.24  ?  404 LEU R CA  1 
ATOM   1954 C C   . LEU A 1 419 ? 121.002 140.583 131.104 1.00 79.24  ?  404 LEU R C   1 
ATOM   1955 O O   . LEU A 1 419 ? 120.154 140.498 131.995 1.00 79.24  ?  404 LEU R O   1 
ATOM   1956 C CB  . LEU A 1 419 ? 122.899 141.642 132.296 1.00 79.24  ?  404 LEU R CB  1 
ATOM   1957 C CG  . LEU A 1 419 ? 124.233 141.555 133.030 1.00 79.24  ?  404 LEU R CG  1 
ATOM   1958 C CD1 . LEU A 1 419 ? 124.541 142.872 133.714 1.00 79.24  ?  404 LEU R CD1 1 
ATOM   1959 C CD2 . LEU A 1 419 ? 124.203 140.427 134.036 1.00 79.24  ?  404 LEU R CD2 1 
ATOM   1960 N N   . ARG A 1 420 ? 120.675 140.813 129.837 1.00 81.67  ?  405 ARG R N   1 
ATOM   1961 C CA  . ARG A 1 420 ? 119.291 140.932 129.421 1.00 81.67  ?  405 ARG R CA  1 
ATOM   1962 C C   . ARG A 1 420 ? 118.751 139.622 128.864 1.00 81.67  ?  405 ARG R C   1 
ATOM   1963 O O   . ARG A 1 420 ? 117.530 139.451 128.782 1.00 81.67  ?  405 ARG R O   1 
ATOM   1964 C CB  . ARG A 1 420 ? 119.155 142.069 128.390 1.00 81.67  ?  405 ARG R CB  1 
ATOM   1965 C CG  . ARG A 1 420 ? 117.735 142.584 128.141 1.00 81.67  ?  405 ARG R CG  1 
ATOM   1966 C CD  . ARG A 1 420 ? 117.715 143.837 127.280 1.00 81.67  ?  405 ARG R CD  1 
ATOM   1967 N NE  . ARG A 1 420 ? 118.194 143.596 125.926 1.00 81.67  ?  405 ARG R NE  1 
ATOM   1968 C CZ  . ARG A 1 420 ? 119.309 144.116 125.428 1.00 81.67  ?  405 ARG R CZ  1 
ATOM   1969 N NH1 . ARG A 1 420 ? 119.671 143.847 124.182 1.00 81.67  ?  405 ARG R NH1 1 
ATOM   1970 N NH2 . ARG A 1 420 ? 120.065 144.905 126.179 1.00 81.67  ?  405 ARG R NH2 1 
ATOM   1971 N N   . HIS A 1 421 ? 119.626 138.674 128.532 1.00 83.11  ?  406 HIS R N   1 
ATOM   1972 C CA  . HIS A 1 421 ? 119.221 137.347 128.088 1.00 83.11  ?  406 HIS R CA  1 
ATOM   1973 C C   . HIS A 1 421 ? 119.232 136.325 129.220 1.00 83.11  ?  406 HIS R C   1 
ATOM   1974 O O   . HIS A 1 421 ? 118.422 135.393 129.217 1.00 83.11  ?  406 HIS R O   1 
ATOM   1975 C CB  . HIS A 1 421 ? 120.128 136.875 126.947 1.00 83.11  ?  406 HIS R CB  1 
ATOM   1976 C CG  . HIS A 1 421 ? 119.769 135.524 126.413 1.00 83.11  ?  406 HIS R CG  1 
ATOM   1977 N ND1 . HIS A 1 421 ? 118.647 135.302 125.646 1.00 83.11  ?  406 HIS R ND1 1 
ATOM   1978 C CD2 . HIS A 1 421 ? 120.384 134.324 126.538 1.00 83.11  ?  406 HIS R CD2 1 
ATOM   1979 C CE1 . HIS A 1 421 ? 118.585 134.023 125.321 1.00 83.11  ?  406 HIS R CE1 1 
ATOM   1980 N NE2 . HIS A 1 421 ? 119.627 133.407 125.850 1.00 83.11  ?  406 HIS R NE2 1 
ATOM   1981 N N   . ALA A 1 422 ? 120.138 136.477 130.188 1.00 81.94  ?  407 ALA R N   1 
ATOM   1982 C CA  . ALA A 1 422 ? 120.171 135.608 131.359 1.00 81.94  ?  407 ALA R CA  1 
ATOM   1983 C C   . ALA A 1 422 ? 118.950 135.840 132.242 1.00 81.94  ?  407 ALA R C   1 
ATOM   1984 O O   . ALA A 1 422 ? 118.483 134.925 132.927 1.00 81.94  ?  407 ALA R O   1 
ATOM   1985 C CB  . ALA A 1 422 ? 121.457 135.830 132.157 1.00 81.94  ?  407 ALA R CB  1 
ATOM   1986 N N   . PHE A 1 423 ? 118.439 137.070 132.233 1.00 83.48  ?  408 PHE R N   1 
ATOM   1987 C CA  . PHE A 1 423 ? 117.200 137.398 132.937 1.00 83.48  ?  408 PHE R CA  1 
ATOM   1988 C C   . PHE A 1 423 ? 116.002 136.709 132.290 1.00 83.48  ?  408 PHE R C   1 
ATOM   1989 O O   . PHE A 1 423 ? 115.084 136.257 132.980 1.00 83.48  ?  408 PHE R O   1 
ATOM   1990 C CB  . PHE A 1 423 ? 117.014 138.919 132.959 1.00 83.48  ?  408 PHE R CB  1 
ATOM   1991 C CG  . PHE A 1 423 ? 115.721 139.370 133.572 1.00 83.48  ?  408 PHE R CG  1 
ATOM   1992 C CD1 . PHE A 1 423 ? 115.533 139.327 134.944 1.00 83.48  ?  408 PHE R CD1 1 
ATOM   1993 C CD2 . PHE A 1 423 ? 114.700 139.860 132.774 1.00 83.48  ?  408 PHE R CD2 1 
ATOM   1994 C CE1 . PHE A 1 423 ? 114.344 139.751 135.508 1.00 83.48  ?  408 PHE R CE1 1 
ATOM   1995 C CE2 . PHE A 1 423 ? 113.510 140.284 133.328 1.00 83.48  ?  408 PHE R CE2 1 
ATOM   1996 C CZ  . PHE A 1 423 ? 113.333 140.230 134.697 1.00 83.48  ?  408 PHE R CZ  1 
ATOM   1997 N N   . ARG A 1 424 ? 116.003 136.631 130.960 1.00 88.08  ?  409 ARG R N   1 
ATOM   1998 C CA  . ARG A 1 424 ? 114.874 136.130 130.183 1.00 88.08  ?  409 ARG R CA  1 
ATOM   1999 C C   . ARG A 1 424 ? 114.639 134.639 130.400 1.00 88.08  ?  409 ARG R C   1 
ATOM   2000 O O   . ARG A 1 424 ? 113.500 134.164 130.322 1.00 88.08  ?  409 ARG R O   1 
ATOM   2001 C CB  . ARG A 1 424 ? 115.106 136.444 128.698 1.00 88.08  ?  409 ARG R CB  1 
ATOM   2002 C CG  . ARG A 1 424 ? 114.035 135.973 127.711 1.00 88.08  ?  409 ARG R CG  1 
ATOM   2003 C CD  . ARG A 1 424 ? 112.780 136.839 127.726 1.00 88.08  ?  409 ARG R CD  1 
ATOM   2004 N NE  . ARG A 1 424 ? 111.845 136.439 128.775 1.00 88.08  ?  409 ARG R NE  1 
ATOM   2005 C CZ  . ARG A 1 424 ? 110.991 135.425 128.677 1.00 88.08  ?  409 ARG R CZ  1 
ATOM   2006 N NH1 . ARG A 1 424 ? 110.187 135.138 129.691 1.00 88.08  ?  409 ARG R NH1 1 
ATOM   2007 N NH2 . ARG A 1 424 ? 110.928 134.703 127.566 1.00 88.08  ?  409 ARG R NH2 1 
ATOM   2008 N N   . SER A 1 425 ? 115.694 133.898 130.732 1.00 86.44  ?  410 SER R N   1 
ATOM   2009 C CA  . SER A 1 425 ? 115.590 132.453 130.855 1.00 86.44  ?  410 SER R CA  1 
ATOM   2010 C C   . SER A 1 425 ? 115.263 131.974 132.262 1.00 86.44  ?  410 SER R C   1 
ATOM   2011 O O   . SER A 1 425 ? 114.968 130.786 132.431 1.00 86.44  ?  410 SER R O   1 
ATOM   2012 C CB  . SER A 1 425 ? 116.888 131.779 130.385 1.00 86.44  ?  410 SER R CB  1 
ATOM   2013 O OG  . SER A 1 425 ? 116.776 130.370 130.444 1.00 86.44  ?  410 SER R OG  1 
ATOM   2014 N N   . MET A 1 426 ? 115.294 132.844 133.266 1.00 85.32  ?  411 MET R N   1 
ATOM   2015 C CA  . MET A 1 426 ? 114.889 132.466 134.615 1.00 85.32  ?  411 MET R CA  1 
ATOM   2016 C C   . MET A 1 426 ? 114.135 133.605 135.300 1.00 85.32  ?  411 MET R C   1 
ATOM   2017 O O   . MET A 1 426 ? 113.026 133.961 134.898 1.00 85.32  ?  411 MET R O   1 
ATOM   2018 C CB  . MET A 1 426 ? 116.106 132.065 135.448 1.00 85.32  ?  411 MET R CB  1 
HETATM 2019 C C01 . YVF B 2 .   ? 124.537 167.952 157.636 1.00 73.47  ?  501 YVF R C01 1 
HETATM 2020 C C03 . YVF B 2 .   ? 123.657 165.783 157.581 1.00 73.47  ?  501 YVF R C03 1 
HETATM 2021 C C04 . YVF B 2 .   ? 123.548 164.416 156.908 1.00 73.47  ?  501 YVF R C04 1 
HETATM 2022 C C05 . YVF B 2 .   ? 123.993 163.331 157.869 1.00 73.47  ?  501 YVF R C05 1 
HETATM 2023 C C06 . YVF B 2 .   ? 123.785 163.328 159.282 1.00 73.47  ?  501 YVF R C06 1 
HETATM 2024 C C07 . YVF B 2 .   ? 124.375 162.061 159.883 1.00 73.47  ?  501 YVF R C07 1 
HETATM 2025 C C08 . YVF B 2 .   ? 124.954 161.258 158.849 1.00 73.47  ?  501 YVF R C08 1 
HETATM 2026 C C10 . YVF B 2 .   ? 122.092 164.125 156.586 1.00 73.47  ?  501 YVF R C10 1 
HETATM 2027 C C12 . YVF B 2 .   ? 124.330 165.172 154.564 1.00 73.47  ?  501 YVF R C12 1 
HETATM 2028 C C13 . YVF B 2 .   ? 125.271 164.922 153.393 1.00 73.47  ?  501 YVF R C13 1 
HETATM 2029 C C16 . YVF B 2 .   ? 128.410 164.054 151.988 1.00 73.47  ?  501 YVF R C16 1 
HETATM 2030 C C17 . YVF B 2 .   ? 129.350 164.695 152.773 1.00 73.47  ?  501 YVF R C17 1 
HETATM 2031 C C18 . YVF B 2 .   ? 130.688 164.375 152.664 1.00 73.47  ?  501 YVF R C18 1 
HETATM 2032 C C19 . YVF B 2 .   ? 131.709 165.098 153.529 1.00 73.47  ?  501 YVF R C19 1 
HETATM 2033 C C23 . YVF B 2 .   ? 131.099 163.402 151.775 1.00 73.47  ?  501 YVF R C23 1 
HETATM 2034 C C24 . YVF B 2 .   ? 130.164 162.745 150.993 1.00 73.47  ?  501 YVF R C24 1 
HETATM 2035 C C25 . YVF B 2 .   ? 128.822 163.062 151.111 1.00 73.47  ?  501 YVF R C25 1 
HETATM 2036 C C26 . YVF B 2 .   ? 126.064 164.730 151.324 1.00 73.47  ?  501 YVF R C26 1 
HETATM 2037 C C27 . YVF B 2 .   ? 126.071 164.758 149.794 1.00 73.47  ?  501 YVF R C27 1 
HETATM 2038 C C28 . YVF B 2 .   ? 124.949 165.037 152.055 1.00 73.47  ?  501 YVF R C28 1 
HETATM 2039 F F20 . YVF B 2 .   ? 131.994 166.301 152.972 1.00 73.47  ?  501 YVF R F20 1 
HETATM 2040 F F21 . YVF B 2 .   ? 132.850 164.361 153.611 1.00 73.47  ?  501 YVF R F21 1 
HETATM 2041 F F22 . YVF B 2 .   ? 131.196 165.280 154.776 1.00 73.47  ?  501 YVF R F22 1 
HETATM 2042 N N11 . YVF B 2 .   ? 124.387 164.299 155.725 1.00 73.47  ?  501 YVF R N11 1 
HETATM 2043 N N14 . YVF B 2 .   ? 126.545 164.555 153.463 1.00 73.47  ?  501 YVF R N14 1 
HETATM 2044 N N15 . YVF B 2 .   ? 127.021 164.441 152.189 1.00 73.47  ?  501 YVF R N15 1 
HETATM 2045 O O02 . YVF B 2 .   ? 124.754 166.607 157.325 1.00 73.47  ?  501 YVF R O02 1 
HETATM 2046 O O29 . YVF B 2 .   ? 123.586 166.090 154.491 1.00 73.47  ?  501 YVF R O29 1 
HETATM 2047 O O30 . YVF B 2 .   ? 122.805 166.143 158.322 1.00 73.47  ?  501 YVF R O30 1 
HETATM 2048 S S09 . YVF B 2 .   ? 124.766 161.990 157.422 1.00 73.47  ?  501 YVF R S09 1 
# 
