data_9DG1
# 
_entry.id   9DG1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DG1         pdb_00009dg1 10.2210/pdb9dg1/pdb 
WWPDB D_1000288028 ?            ?                   
EMDB  EMD-46821    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-06 
2 'Structure model' 1 1 2024-11-13 
3 'Structure model' 1 2 2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
3 3 'Structure model' 'Data collection'     
4 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
4 3 'Structure model' citation        
5 3 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
12 2 'Structure model' '_em_admin.last_update'             
13 3 'Structure model' '_citation.journal_volume'          
14 3 'Structure model' '_citation.title'                   
15 3 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DG1 
_pdbx_database_status.recvd_initial_deposition_date   2024-09-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'Structure of Plasmodium falciparum apicoplast DNA polymerase in complex with DNA (exo-minus)' 
_pdbx_database_related.db_id          EMD-46821 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              yg60@rice.edu 
_pdbx_contact_author.name_first         Yang 
_pdbx_contact_author.name_last          Gao 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-4037-0431 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Lo, C.-Y.' 1 ? 
'Gao, Y.'   2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Mol.Biol. 
_citation.journal_id_ASTM           JMOBAK 
_citation.journal_id_CSD            0070 
_citation.journal_id_ISSN           1089-8638 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            436 
_citation.language                  ? 
_citation.page_first                168842 
_citation.page_last                 168842 
_citation.title                     'Cryo-EM Structures of the Plasmodium falciparum Apicoplast DNA Polymerase.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.jmb.2024.168842 
_citation.pdbx_database_id_PubMed   39490679 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Lo, C.Y.'     1 ? 
primary 'Ung, A.R.'    2 ? 
primary 'Koley, T.'    3 ? 
primary 'Nelson, S.W.' 4 ? 
primary 'Gao, Y.'      5 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Plastid replication-repair enzyme'                                           74002.891 1 2.7.7.7 'D82N, E84Q' ? ? 
2 polymer syn 
;DNA (5'-D(P*AP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*CP*CP*TP*CP*AP*CP*AP*G)-3')
;
8864.712  1 ?       ?            ? ? 
3 polymer syn 
;DNA (5'-D(*AP*CP*TP*GP*TP*GP*AP*GP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3')
;
6158.002  1 ?       ?            ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)'        no no  
;DEITKKYIKDNIINVDDNIIKKKDIFKLKNENNEITECAFEYFESKKKFDDDIESRFFIINDNNYNENINLIYKDIKYCG
LNIQTTGLEVFDENIRLIQIAVENYPVIIYDMFNINKKDILDGLRKVLENKNIIKIIQNGKFDAKFLLHNNFKIENIFDT
YIASKLLDKNKNMYGFKLNNIVEKYLNVILDKQQQNSVWNNSLLNNNQLFYAARDSSCLLKLYKKLKEEIKKENLHIVND
IENKCILPICDMELNGIKVDLENLQKSTNEILNELNIEKDNLKKKLKDENINVNSQQQVLKALQKNNVRDISNKLIENTS
DSNLKNFLNHEEIISLRNYRRLYKLYSAFYLKLPLHINTKTNKIHTTFNQLKTFSGRFSSEKPNLQQIPRQKNIREIFIP
NDNNIFIIADFKQIELKIAAEITNDEIMLKAYNNNIDLHTLTASIITKKNIPDINKEDRHIAKAINFGLIYGMNYVNLKN
YANTYYGLNMSLDQCLYFYNSFFEHYKGIYKWHNQVKQKRALQYSTLSNRKVIFPYFSFTKALNYPVQGTCADILKLALV
DLYDNLKDINGKIILCVHDEIIIEVNKKFQEEALKILVQSMENSASYFLKKVKCEVSVKIAENWGSKD
;
;DEITKKYIKDNIINVDDNIIKKKDIFKLKNENNEITECAFEYFESKKKFDDDIESRFFIINDNNYNENINLIYKDIKYCG
LNIQTTGLEVFDENIRLIQIAVENYPVIIYDMFNINKKDILDGLRKVLENKNIIKIIQNGKFDAKFLLHNNFKIENIFDT
YIASKLLDKNKNMYGFKLNNIVEKYLNVILDKQQQNSVWNNSLLNNNQLFYAARDSSCLLKLYKKLKEEIKKENLHIVND
IENKCILPICDMELNGIKVDLENLQKSTNEILNELNIEKDNLKKKLKDENINVNSQQQVLKALQKNNVRDISNKLIENTS
DSNLKNFLNHEEIISLRNYRRLYKLYSAFYLKLPLHINTKTNKIHTTFNQLKTFSGRFSSEKPNLQQIPRQKNIREIFIP
NDNNIFIIADFKQIELKIAAEITNDEIMLKAYNNNIDLHTLTASIITKKNIPDINKEDRHIAKAINFGLIYGMNYVNLKN
YANTYYGLNMSLDQCLYFYNSFFEHYKGIYKWHNQVKQKRALQYSTLSNRKVIFPYFSFTKALNYPVQGTCADILKLALV
DLYDNLKDINGKIILCVHDEIIIEVNKKFQEEALKILVQSMENSASYFLKKVKCEVSVKIAENWGSKD
;
A ? 
2 polydeoxyribonucleotide no no  
;(DG)(DC)(DA)(DG)(DT)(DC)(DA)(DG)(DC)(DT)(DC)(DT)(DA)(DC)(DG)(DG)(DA)(DT)(DG)(DC)
(DC)(DT)(DC)(DA)(DC)(DA)(DG)(DC)(DA)
;
GCAGTCAGCTCTACGGATGCCTCACAGCA E ? 
3 polydeoxyribonucleotide no yes 
;(DT)(DA)(DC)(DT)(DG)(DT)(DG)(DA)(DG)(DG)(DC)(DA)(DT)(DC)(DC)(DG)(DT)(DA)(DG)
(2DA)
;
TACTGTGAGGCATCCGTAGA F ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   GLU n 
1 3   ILE n 
1 4   THR n 
1 5   LYS n 
1 6   LYS n 
1 7   TYR n 
1 8   ILE n 
1 9   LYS n 
1 10  ASP n 
1 11  ASN n 
1 12  ILE n 
1 13  ILE n 
1 14  ASN n 
1 15  VAL n 
1 16  ASP n 
1 17  ASP n 
1 18  ASN n 
1 19  ILE n 
1 20  ILE n 
1 21  LYS n 
1 22  LYS n 
1 23  LYS n 
1 24  ASP n 
1 25  ILE n 
1 26  PHE n 
1 27  LYS n 
1 28  LEU n 
1 29  LYS n 
1 30  ASN n 
1 31  GLU n 
1 32  ASN n 
1 33  ASN n 
1 34  GLU n 
1 35  ILE n 
1 36  THR n 
1 37  GLU n 
1 38  CYS n 
1 39  ALA n 
1 40  PHE n 
1 41  GLU n 
1 42  TYR n 
1 43  PHE n 
1 44  GLU n 
1 45  SER n 
1 46  LYS n 
1 47  LYS n 
1 48  LYS n 
1 49  PHE n 
1 50  ASP n 
1 51  ASP n 
1 52  ASP n 
1 53  ILE n 
1 54  GLU n 
1 55  SER n 
1 56  ARG n 
1 57  PHE n 
1 58  PHE n 
1 59  ILE n 
1 60  ILE n 
1 61  ASN n 
1 62  ASP n 
1 63  ASN n 
1 64  ASN n 
1 65  TYR n 
1 66  ASN n 
1 67  GLU n 
1 68  ASN n 
1 69  ILE n 
1 70  ASN n 
1 71  LEU n 
1 72  ILE n 
1 73  TYR n 
1 74  LYS n 
1 75  ASP n 
1 76  ILE n 
1 77  LYS n 
1 78  TYR n 
1 79  CYS n 
1 80  GLY n 
1 81  LEU n 
1 82  ASN n 
1 83  ILE n 
1 84  GLN n 
1 85  THR n 
1 86  THR n 
1 87  GLY n 
1 88  LEU n 
1 89  GLU n 
1 90  VAL n 
1 91  PHE n 
1 92  ASP n 
1 93  GLU n 
1 94  ASN n 
1 95  ILE n 
1 96  ARG n 
1 97  LEU n 
1 98  ILE n 
1 99  GLN n 
1 100 ILE n 
1 101 ALA n 
1 102 VAL n 
1 103 GLU n 
1 104 ASN n 
1 105 TYR n 
1 106 PRO n 
1 107 VAL n 
1 108 ILE n 
1 109 ILE n 
1 110 TYR n 
1 111 ASP n 
1 112 MET n 
1 113 PHE n 
1 114 ASN n 
1 115 ILE n 
1 116 ASN n 
1 117 LYS n 
1 118 LYS n 
1 119 ASP n 
1 120 ILE n 
1 121 LEU n 
1 122 ASP n 
1 123 GLY n 
1 124 LEU n 
1 125 ARG n 
1 126 LYS n 
1 127 VAL n 
1 128 LEU n 
1 129 GLU n 
1 130 ASN n 
1 131 LYS n 
1 132 ASN n 
1 133 ILE n 
1 134 ILE n 
1 135 LYS n 
1 136 ILE n 
1 137 ILE n 
1 138 GLN n 
1 139 ASN n 
1 140 GLY n 
1 141 LYS n 
1 142 PHE n 
1 143 ASP n 
1 144 ALA n 
1 145 LYS n 
1 146 PHE n 
1 147 LEU n 
1 148 LEU n 
1 149 HIS n 
1 150 ASN n 
1 151 ASN n 
1 152 PHE n 
1 153 LYS n 
1 154 ILE n 
1 155 GLU n 
1 156 ASN n 
1 157 ILE n 
1 158 PHE n 
1 159 ASP n 
1 160 THR n 
1 161 TYR n 
1 162 ILE n 
1 163 ALA n 
1 164 SER n 
1 165 LYS n 
1 166 LEU n 
1 167 LEU n 
1 168 ASP n 
1 169 LYS n 
1 170 ASN n 
1 171 LYS n 
1 172 ASN n 
1 173 MET n 
1 174 TYR n 
1 175 GLY n 
1 176 PHE n 
1 177 LYS n 
1 178 LEU n 
1 179 ASN n 
1 180 ASN n 
1 181 ILE n 
1 182 VAL n 
1 183 GLU n 
1 184 LYS n 
1 185 TYR n 
1 186 LEU n 
1 187 ASN n 
1 188 VAL n 
1 189 ILE n 
1 190 LEU n 
1 191 ASP n 
1 192 LYS n 
1 193 GLN n 
1 194 GLN n 
1 195 GLN n 
1 196 ASN n 
1 197 SER n 
1 198 VAL n 
1 199 TRP n 
1 200 ASN n 
1 201 ASN n 
1 202 SER n 
1 203 LEU n 
1 204 LEU n 
1 205 ASN n 
1 206 ASN n 
1 207 ASN n 
1 208 GLN n 
1 209 LEU n 
1 210 PHE n 
1 211 TYR n 
1 212 ALA n 
1 213 ALA n 
1 214 ARG n 
1 215 ASP n 
1 216 SER n 
1 217 SER n 
1 218 CYS n 
1 219 LEU n 
1 220 LEU n 
1 221 LYS n 
1 222 LEU n 
1 223 TYR n 
1 224 LYS n 
1 225 LYS n 
1 226 LEU n 
1 227 LYS n 
1 228 GLU n 
1 229 GLU n 
1 230 ILE n 
1 231 LYS n 
1 232 LYS n 
1 233 GLU n 
1 234 ASN n 
1 235 LEU n 
1 236 HIS n 
1 237 ILE n 
1 238 VAL n 
1 239 ASN n 
1 240 ASP n 
1 241 ILE n 
1 242 GLU n 
1 243 ASN n 
1 244 LYS n 
1 245 CYS n 
1 246 ILE n 
1 247 LEU n 
1 248 PRO n 
1 249 ILE n 
1 250 CYS n 
1 251 ASP n 
1 252 MET n 
1 253 GLU n 
1 254 LEU n 
1 255 ASN n 
1 256 GLY n 
1 257 ILE n 
1 258 LYS n 
1 259 VAL n 
1 260 ASP n 
1 261 LEU n 
1 262 GLU n 
1 263 ASN n 
1 264 LEU n 
1 265 GLN n 
1 266 LYS n 
1 267 SER n 
1 268 THR n 
1 269 ASN n 
1 270 GLU n 
1 271 ILE n 
1 272 LEU n 
1 273 ASN n 
1 274 GLU n 
1 275 LEU n 
1 276 ASN n 
1 277 ILE n 
1 278 GLU n 
1 279 LYS n 
1 280 ASP n 
1 281 ASN n 
1 282 LEU n 
1 283 LYS n 
1 284 LYS n 
1 285 LYS n 
1 286 LEU n 
1 287 LYS n 
1 288 ASP n 
1 289 GLU n 
1 290 ASN n 
1 291 ILE n 
1 292 ASN n 
1 293 VAL n 
1 294 ASN n 
1 295 SER n 
1 296 GLN n 
1 297 GLN n 
1 298 GLN n 
1 299 VAL n 
1 300 LEU n 
1 301 LYS n 
1 302 ALA n 
1 303 LEU n 
1 304 GLN n 
1 305 LYS n 
1 306 ASN n 
1 307 ASN n 
1 308 VAL n 
1 309 ARG n 
1 310 ASP n 
1 311 ILE n 
1 312 SER n 
1 313 ASN n 
1 314 LYS n 
1 315 LEU n 
1 316 ILE n 
1 317 GLU n 
1 318 ASN n 
1 319 THR n 
1 320 SER n 
1 321 ASP n 
1 322 SER n 
1 323 ASN n 
1 324 LEU n 
1 325 LYS n 
1 326 ASN n 
1 327 PHE n 
1 328 LEU n 
1 329 ASN n 
1 330 HIS n 
1 331 GLU n 
1 332 GLU n 
1 333 ILE n 
1 334 ILE n 
1 335 SER n 
1 336 LEU n 
1 337 ARG n 
1 338 ASN n 
1 339 TYR n 
1 340 ARG n 
1 341 ARG n 
1 342 LEU n 
1 343 TYR n 
1 344 LYS n 
1 345 LEU n 
1 346 TYR n 
1 347 SER n 
1 348 ALA n 
1 349 PHE n 
1 350 TYR n 
1 351 LEU n 
1 352 LYS n 
1 353 LEU n 
1 354 PRO n 
1 355 LEU n 
1 356 HIS n 
1 357 ILE n 
1 358 ASN n 
1 359 THR n 
1 360 LYS n 
1 361 THR n 
1 362 ASN n 
1 363 LYS n 
1 364 ILE n 
1 365 HIS n 
1 366 THR n 
1 367 THR n 
1 368 PHE n 
1 369 ASN n 
1 370 GLN n 
1 371 LEU n 
1 372 LYS n 
1 373 THR n 
1 374 PHE n 
1 375 SER n 
1 376 GLY n 
1 377 ARG n 
1 378 PHE n 
1 379 SER n 
1 380 SER n 
1 381 GLU n 
1 382 LYS n 
1 383 PRO n 
1 384 ASN n 
1 385 LEU n 
1 386 GLN n 
1 387 GLN n 
1 388 ILE n 
1 389 PRO n 
1 390 ARG n 
1 391 GLN n 
1 392 LYS n 
1 393 ASN n 
1 394 ILE n 
1 395 ARG n 
1 396 GLU n 
1 397 ILE n 
1 398 PHE n 
1 399 ILE n 
1 400 PRO n 
1 401 ASN n 
1 402 ASP n 
1 403 ASN n 
1 404 ASN n 
1 405 ILE n 
1 406 PHE n 
1 407 ILE n 
1 408 ILE n 
1 409 ALA n 
1 410 ASP n 
1 411 PHE n 
1 412 LYS n 
1 413 GLN n 
1 414 ILE n 
1 415 GLU n 
1 416 LEU n 
1 417 LYS n 
1 418 ILE n 
1 419 ALA n 
1 420 ALA n 
1 421 GLU n 
1 422 ILE n 
1 423 THR n 
1 424 ASN n 
1 425 ASP n 
1 426 GLU n 
1 427 ILE n 
1 428 MET n 
1 429 LEU n 
1 430 LYS n 
1 431 ALA n 
1 432 TYR n 
1 433 ASN n 
1 434 ASN n 
1 435 ASN n 
1 436 ILE n 
1 437 ASP n 
1 438 LEU n 
1 439 HIS n 
1 440 THR n 
1 441 LEU n 
1 442 THR n 
1 443 ALA n 
1 444 SER n 
1 445 ILE n 
1 446 ILE n 
1 447 THR n 
1 448 LYS n 
1 449 LYS n 
1 450 ASN n 
1 451 ILE n 
1 452 PRO n 
1 453 ASP n 
1 454 ILE n 
1 455 ASN n 
1 456 LYS n 
1 457 GLU n 
1 458 ASP n 
1 459 ARG n 
1 460 HIS n 
1 461 ILE n 
1 462 ALA n 
1 463 LYS n 
1 464 ALA n 
1 465 ILE n 
1 466 ASN n 
1 467 PHE n 
1 468 GLY n 
1 469 LEU n 
1 470 ILE n 
1 471 TYR n 
1 472 GLY n 
1 473 MET n 
1 474 ASN n 
1 475 TYR n 
1 476 VAL n 
1 477 ASN n 
1 478 LEU n 
1 479 LYS n 
1 480 ASN n 
1 481 TYR n 
1 482 ALA n 
1 483 ASN n 
1 484 THR n 
1 485 TYR n 
1 486 TYR n 
1 487 GLY n 
1 488 LEU n 
1 489 ASN n 
1 490 MET n 
1 491 SER n 
1 492 LEU n 
1 493 ASP n 
1 494 GLN n 
1 495 CYS n 
1 496 LEU n 
1 497 TYR n 
1 498 PHE n 
1 499 TYR n 
1 500 ASN n 
1 501 SER n 
1 502 PHE n 
1 503 PHE n 
1 504 GLU n 
1 505 HIS n 
1 506 TYR n 
1 507 LYS n 
1 508 GLY n 
1 509 ILE n 
1 510 TYR n 
1 511 LYS n 
1 512 TRP n 
1 513 HIS n 
1 514 ASN n 
1 515 GLN n 
1 516 VAL n 
1 517 LYS n 
1 518 GLN n 
1 519 LYS n 
1 520 ARG n 
1 521 ALA n 
1 522 LEU n 
1 523 GLN n 
1 524 TYR n 
1 525 SER n 
1 526 THR n 
1 527 LEU n 
1 528 SER n 
1 529 ASN n 
1 530 ARG n 
1 531 LYS n 
1 532 VAL n 
1 533 ILE n 
1 534 PHE n 
1 535 PRO n 
1 536 TYR n 
1 537 PHE n 
1 538 SER n 
1 539 PHE n 
1 540 THR n 
1 541 LYS n 
1 542 ALA n 
1 543 LEU n 
1 544 ASN n 
1 545 TYR n 
1 546 PRO n 
1 547 VAL n 
1 548 GLN n 
1 549 GLY n 
1 550 THR n 
1 551 CYS n 
1 552 ALA n 
1 553 ASP n 
1 554 ILE n 
1 555 LEU n 
1 556 LYS n 
1 557 LEU n 
1 558 ALA n 
1 559 LEU n 
1 560 VAL n 
1 561 ASP n 
1 562 LEU n 
1 563 TYR n 
1 564 ASP n 
1 565 ASN n 
1 566 LEU n 
1 567 LYS n 
1 568 ASP n 
1 569 ILE n 
1 570 ASN n 
1 571 GLY n 
1 572 LYS n 
1 573 ILE n 
1 574 ILE n 
1 575 LEU n 
1 576 CYS n 
1 577 VAL n 
1 578 HIS n 
1 579 ASP n 
1 580 GLU n 
1 581 ILE n 
1 582 ILE n 
1 583 ILE n 
1 584 GLU n 
1 585 VAL n 
1 586 ASN n 
1 587 LYS n 
1 588 LYS n 
1 589 PHE n 
1 590 GLN n 
1 591 GLU n 
1 592 GLU n 
1 593 ALA n 
1 594 LEU n 
1 595 LYS n 
1 596 ILE n 
1 597 LEU n 
1 598 VAL n 
1 599 GLN n 
1 600 SER n 
1 601 MET n 
1 602 GLU n 
1 603 ASN n 
1 604 SER n 
1 605 ALA n 
1 606 SER n 
1 607 TYR n 
1 608 PHE n 
1 609 LEU n 
1 610 LYS n 
1 611 LYS n 
1 612 VAL n 
1 613 LYS n 
1 614 CYS n 
1 615 GLU n 
1 616 VAL n 
1 617 SER n 
1 618 VAL n 
1 619 LYS n 
1 620 ILE n 
1 621 ALA n 
1 622 GLU n 
1 623 ASN n 
1 624 TRP n 
1 625 GLY n 
1 626 SER n 
1 627 LYS n 
1 628 ASP n 
2 1   DG  n 
2 2   DC  n 
2 3   DA  n 
2 4   DG  n 
2 5   DT  n 
2 6   DC  n 
2 7   DA  n 
2 8   DG  n 
2 9   DC  n 
2 10  DT  n 
2 11  DC  n 
2 12  DT  n 
2 13  DA  n 
2 14  DC  n 
2 15  DG  n 
2 16  DG  n 
2 17  DA  n 
2 18  DT  n 
2 19  DG  n 
2 20  DC  n 
2 21  DC  n 
2 22  DT  n 
2 23  DC  n 
2 24  DA  n 
2 25  DC  n 
2 26  DA  n 
2 27  DG  n 
2 28  DC  n 
2 29  DA  n 
3 1   DT  n 
3 2   DA  n 
3 3   DC  n 
3 4   DT  n 
3 5   DG  n 
3 6   DT  n 
3 7   DG  n 
3 8   DA  n 
3 9   DG  n 
3 10  DG  n 
3 11  DC  n 
3 12  DA  n 
3 13  DT  n 
3 14  DC  n 
3 15  DC  n 
3 16  DG  n 
3 17  DT  n 
3 18  DA  n 
3 19  DG  n 
3 20  2DA n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   628 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Plasmodium falciparum 3D7' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     36329 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     866768 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_pdbx_entity_src_syn.entity_id 
_pdbx_entity_src_syn.pdbx_src_id 
_pdbx_entity_src_syn.pdbx_alt_source_flag 
_pdbx_entity_src_syn.pdbx_beg_seq_num 
_pdbx_entity_src_syn.pdbx_end_seq_num 
_pdbx_entity_src_syn.organism_scientific 
_pdbx_entity_src_syn.organism_common_name 
_pdbx_entity_src_syn.ncbi_taxonomy_id 
_pdbx_entity_src_syn.details 
2 1 sample 1 29 'Homo sapiens' human 9606 ? 
3 1 sample 1 20 'Homo sapiens' human 9606 ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
2DA 'DNA linking'       n "2',3'-DIDEOXYADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O5 P' 315.222 
ALA 'L-peptide linking' y ALANINE                                   ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                                  ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                                ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                           ? 'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE                                  ? 'C3 H7 N O2 S'    121.158 
DA  'DNA linking'       y "2'-DEOXYADENOSINE-5'-MONOPHOSPHATE"      ? 'C10 H14 N5 O6 P' 331.222 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE"       ? 'C9 H14 N3 O7 P'  307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE"      ? 'C10 H14 N5 O7 P' 347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE"              ? 'C10 H15 N2 O8 P' 322.208 
GLN 'L-peptide linking' y GLUTAMINE                                 ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                           ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                                   ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                                 ? 'C6 H10 N3 O2 1'  156.162 
ILE 'L-peptide linking' y ISOLEUCINE                                ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                                   ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                                    ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                                ? 'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE                             ? 'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE                                   ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                                    ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                                 ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                                  ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                                    ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   1   ?   ?   ?   A . n 
A 1 2   GLU 2   2   ?   ?   ?   A . n 
A 1 3   ILE 3   3   ?   ?   ?   A . n 
A 1 4   THR 4   4   ?   ?   ?   A . n 
A 1 5   LYS 5   5   ?   ?   ?   A . n 
A 1 6   LYS 6   6   ?   ?   ?   A . n 
A 1 7   TYR 7   7   ?   ?   ?   A . n 
A 1 8   ILE 8   8   ?   ?   ?   A . n 
A 1 9   LYS 9   9   ?   ?   ?   A . n 
A 1 10  ASP 10  10  ?   ?   ?   A . n 
A 1 11  ASN 11  11  ?   ?   ?   A . n 
A 1 12  ILE 12  12  ?   ?   ?   A . n 
A 1 13  ILE 13  13  ?   ?   ?   A . n 
A 1 14  ASN 14  14  ?   ?   ?   A . n 
A 1 15  VAL 15  15  ?   ?   ?   A . n 
A 1 16  ASP 16  16  ?   ?   ?   A . n 
A 1 17  ASP 17  17  ?   ?   ?   A . n 
A 1 18  ASN 18  18  ?   ?   ?   A . n 
A 1 19  ILE 19  19  ?   ?   ?   A . n 
A 1 20  ILE 20  20  ?   ?   ?   A . n 
A 1 21  LYS 21  21  ?   ?   ?   A . n 
A 1 22  LYS 22  22  ?   ?   ?   A . n 
A 1 23  LYS 23  23  ?   ?   ?   A . n 
A 1 24  ASP 24  24  ?   ?   ?   A . n 
A 1 25  ILE 25  25  ?   ?   ?   A . n 
A 1 26  PHE 26  26  ?   ?   ?   A . n 
A 1 27  LYS 27  27  ?   ?   ?   A . n 
A 1 28  LEU 28  28  ?   ?   ?   A . n 
A 1 29  LYS 29  29  ?   ?   ?   A . n 
A 1 30  ASN 30  30  ?   ?   ?   A . n 
A 1 31  GLU 31  31  ?   ?   ?   A . n 
A 1 32  ASN 32  32  ?   ?   ?   A . n 
A 1 33  ASN 33  33  ?   ?   ?   A . n 
A 1 34  GLU 34  34  ?   ?   ?   A . n 
A 1 35  ILE 35  35  ?   ?   ?   A . n 
A 1 36  THR 36  36  ?   ?   ?   A . n 
A 1 37  GLU 37  37  ?   ?   ?   A . n 
A 1 38  CYS 38  38  ?   ?   ?   A . n 
A 1 39  ALA 39  39  ?   ?   ?   A . n 
A 1 40  PHE 40  40  ?   ?   ?   A . n 
A 1 41  GLU 41  41  ?   ?   ?   A . n 
A 1 42  TYR 42  42  ?   ?   ?   A . n 
A 1 43  PHE 43  43  ?   ?   ?   A . n 
A 1 44  GLU 44  44  ?   ?   ?   A . n 
A 1 45  SER 45  45  ?   ?   ?   A . n 
A 1 46  LYS 46  46  ?   ?   ?   A . n 
A 1 47  LYS 47  47  ?   ?   ?   A . n 
A 1 48  LYS 48  48  ?   ?   ?   A . n 
A 1 49  PHE 49  49  ?   ?   ?   A . n 
A 1 50  ASP 50  50  50  ASP ASP A . n 
A 1 51  ASP 51  51  51  ASP ASP A . n 
A 1 52  ASP 52  52  52  ASP ASP A . n 
A 1 53  ILE 53  53  53  ILE ILE A . n 
A 1 54  GLU 54  54  54  GLU GLU A . n 
A 1 55  SER 55  55  55  SER SER A . n 
A 1 56  ARG 56  56  56  ARG ARG A . n 
A 1 57  PHE 57  57  57  PHE PHE A . n 
A 1 58  PHE 58  58  58  PHE PHE A . n 
A 1 59  ILE 59  59  59  ILE ILE A . n 
A 1 60  ILE 60  60  60  ILE ILE A . n 
A 1 61  ASN 61  61  61  ASN ASN A . n 
A 1 62  ASP 62  62  62  ASP ASP A . n 
A 1 63  ASN 63  63  63  ASN ASN A . n 
A 1 64  ASN 64  64  64  ASN ASN A . n 
A 1 65  TYR 65  65  65  TYR TYR A . n 
A 1 66  ASN 66  66  66  ASN ASN A . n 
A 1 67  GLU 67  67  67  GLU GLU A . n 
A 1 68  ASN 68  68  68  ASN ASN A . n 
A 1 69  ILE 69  69  69  ILE ILE A . n 
A 1 70  ASN 70  70  70  ASN ASN A . n 
A 1 71  LEU 71  71  71  LEU LEU A . n 
A 1 72  ILE 72  72  72  ILE ILE A . n 
A 1 73  TYR 73  73  73  TYR TYR A . n 
A 1 74  LYS 74  74  74  LYS LYS A . n 
A 1 75  ASP 75  75  75  ASP ASP A . n 
A 1 76  ILE 76  76  76  ILE ILE A . n 
A 1 77  LYS 77  77  77  LYS LYS A . n 
A 1 78  TYR 78  78  78  TYR TYR A . n 
A 1 79  CYS 79  79  79  CYS CYS A . n 
A 1 80  GLY 80  80  80  GLY GLY A . n 
A 1 81  LEU 81  81  81  LEU LEU A . n 
A 1 82  ASN 82  82  82  ASN ASN A . n 
A 1 83  ILE 83  83  83  ILE ILE A . n 
A 1 84  GLN 84  84  84  GLN GLN A . n 
A 1 85  THR 85  85  85  THR THR A . n 
A 1 86  THR 86  86  86  THR THR A . n 
A 1 87  GLY 87  87  87  GLY GLY A . n 
A 1 88  LEU 88  88  88  LEU LEU A . n 
A 1 89  GLU 89  89  89  GLU GLU A . n 
A 1 90  VAL 90  90  90  VAL VAL A . n 
A 1 91  PHE 91  91  91  PHE PHE A . n 
A 1 92  ASP 92  92  92  ASP ASP A . n 
A 1 93  GLU 93  93  93  GLU GLU A . n 
A 1 94  ASN 94  94  94  ASN ASN A . n 
A 1 95  ILE 95  95  95  ILE ILE A . n 
A 1 96  ARG 96  96  96  ARG ARG A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  ILE 98  98  98  ILE ILE A . n 
A 1 99  GLN 99  99  99  GLN GLN A . n 
A 1 100 ILE 100 100 100 ILE ILE A . n 
A 1 101 ALA 101 101 101 ALA ALA A . n 
A 1 102 VAL 102 102 102 VAL VAL A . n 
A 1 103 GLU 103 103 103 GLU GLU A . n 
A 1 104 ASN 104 104 104 ASN ASN A . n 
A 1 105 TYR 105 105 105 TYR TYR A . n 
A 1 106 PRO 106 106 106 PRO PRO A . n 
A 1 107 VAL 107 107 107 VAL VAL A . n 
A 1 108 ILE 108 108 108 ILE ILE A . n 
A 1 109 ILE 109 109 109 ILE ILE A . n 
A 1 110 TYR 110 110 110 TYR TYR A . n 
A 1 111 ASP 111 111 111 ASP ASP A . n 
A 1 112 MET 112 112 112 MET MET A . n 
A 1 113 PHE 113 113 113 PHE PHE A . n 
A 1 114 ASN 114 114 114 ASN ASN A . n 
A 1 115 ILE 115 115 115 ILE ILE A . n 
A 1 116 ASN 116 116 116 ASN ASN A . n 
A 1 117 LYS 117 117 117 LYS LYS A . n 
A 1 118 LYS 118 118 118 LYS LYS A . n 
A 1 119 ASP 119 119 119 ASP ASP A . n 
A 1 120 ILE 120 120 120 ILE ILE A . n 
A 1 121 LEU 121 121 121 LEU LEU A . n 
A 1 122 ASP 122 122 122 ASP ASP A . n 
A 1 123 GLY 123 123 123 GLY GLY A . n 
A 1 124 LEU 124 124 124 LEU LEU A . n 
A 1 125 ARG 125 125 125 ARG ARG A . n 
A 1 126 LYS 126 126 126 LYS LYS A . n 
A 1 127 VAL 127 127 127 VAL VAL A . n 
A 1 128 LEU 128 128 128 LEU LEU A . n 
A 1 129 GLU 129 129 129 GLU GLU A . n 
A 1 130 ASN 130 130 130 ASN ASN A . n 
A 1 131 LYS 131 131 131 LYS LYS A . n 
A 1 132 ASN 132 132 132 ASN ASN A . n 
A 1 133 ILE 133 133 133 ILE ILE A . n 
A 1 134 ILE 134 134 134 ILE ILE A . n 
A 1 135 LYS 135 135 135 LYS LYS A . n 
A 1 136 ILE 136 136 136 ILE ILE A . n 
A 1 137 ILE 137 137 137 ILE ILE A . n 
A 1 138 GLN 138 138 138 GLN GLN A . n 
A 1 139 ASN 139 139 139 ASN ASN A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 LYS 141 141 141 LYS LYS A . n 
A 1 142 PHE 142 142 142 PHE PHE A . n 
A 1 143 ASP 143 143 143 ASP ASP A . n 
A 1 144 ALA 144 144 144 ALA ALA A . n 
A 1 145 LYS 145 145 145 LYS LYS A . n 
A 1 146 PHE 146 146 146 PHE PHE A . n 
A 1 147 LEU 147 147 147 LEU LEU A . n 
A 1 148 LEU 148 148 148 LEU LEU A . n 
A 1 149 HIS 149 149 149 HIS HIS A . n 
A 1 150 ASN 150 150 150 ASN ASN A . n 
A 1 151 ASN 151 151 151 ASN ASN A . n 
A 1 152 PHE 152 152 152 PHE PHE A . n 
A 1 153 LYS 153 153 153 LYS LYS A . n 
A 1 154 ILE 154 154 154 ILE ILE A . n 
A 1 155 GLU 155 155 155 GLU GLU A . n 
A 1 156 ASN 156 156 156 ASN ASN A . n 
A 1 157 ILE 157 157 157 ILE ILE A . n 
A 1 158 PHE 158 158 158 PHE PHE A . n 
A 1 159 ASP 159 159 159 ASP ASP A . n 
A 1 160 THR 160 160 160 THR THR A . n 
A 1 161 TYR 161 161 161 TYR TYR A . n 
A 1 162 ILE 162 162 162 ILE ILE A . n 
A 1 163 ALA 163 163 163 ALA ALA A . n 
A 1 164 SER 164 164 164 SER SER A . n 
A 1 165 LYS 165 165 165 LYS LYS A . n 
A 1 166 LEU 166 166 166 LEU LEU A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ASP 168 168 168 ASP ASP A . n 
A 1 169 LYS 169 169 169 LYS LYS A . n 
A 1 170 ASN 170 170 170 ASN ASN A . n 
A 1 171 LYS 171 171 171 LYS LYS A . n 
A 1 172 ASN 172 172 172 ASN ASN A . n 
A 1 173 MET 173 173 173 MET MET A . n 
A 1 174 TYR 174 174 ?   ?   ?   A . n 
A 1 175 GLY 175 175 ?   ?   ?   A . n 
A 1 176 PHE 176 176 ?   ?   ?   A . n 
A 1 177 LYS 177 177 ?   ?   ?   A . n 
A 1 178 LEU 178 178 ?   ?   ?   A . n 
A 1 179 ASN 179 179 ?   ?   ?   A . n 
A 1 180 ASN 180 180 ?   ?   ?   A . n 
A 1 181 ILE 181 181 ?   ?   ?   A . n 
A 1 182 VAL 182 182 ?   ?   ?   A . n 
A 1 183 GLU 183 183 ?   ?   ?   A . n 
A 1 184 LYS 184 184 ?   ?   ?   A . n 
A 1 185 TYR 185 185 ?   ?   ?   A . n 
A 1 186 LEU 186 186 ?   ?   ?   A . n 
A 1 187 ASN 187 187 ?   ?   ?   A . n 
A 1 188 VAL 188 188 ?   ?   ?   A . n 
A 1 189 ILE 189 189 ?   ?   ?   A . n 
A 1 190 LEU 190 190 ?   ?   ?   A . n 
A 1 191 ASP 191 191 ?   ?   ?   A . n 
A 1 192 LYS 192 192 ?   ?   ?   A . n 
A 1 193 GLN 193 193 ?   ?   ?   A . n 
A 1 194 GLN 194 194 ?   ?   ?   A . n 
A 1 195 GLN 195 195 ?   ?   ?   A . n 
A 1 196 ASN 196 196 ?   ?   ?   A . n 
A 1 197 SER 197 197 ?   ?   ?   A . n 
A 1 198 VAL 198 198 ?   ?   ?   A . n 
A 1 199 TRP 199 199 ?   ?   ?   A . n 
A 1 200 ASN 200 200 ?   ?   ?   A . n 
A 1 201 ASN 201 201 ?   ?   ?   A . n 
A 1 202 SER 202 202 ?   ?   ?   A . n 
A 1 203 LEU 203 203 ?   ?   ?   A . n 
A 1 204 LEU 204 204 ?   ?   ?   A . n 
A 1 205 ASN 205 205 ?   ?   ?   A . n 
A 1 206 ASN 206 206 ?   ?   ?   A . n 
A 1 207 ASN 207 207 ?   ?   ?   A . n 
A 1 208 GLN 208 208 208 GLN GLN A . n 
A 1 209 LEU 209 209 209 LEU LEU A . n 
A 1 210 PHE 210 210 210 PHE PHE A . n 
A 1 211 TYR 211 211 211 TYR TYR A . n 
A 1 212 ALA 212 212 212 ALA ALA A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 ARG 214 214 214 ARG ARG A . n 
A 1 215 ASP 215 215 215 ASP ASP A . n 
A 1 216 SER 216 216 216 SER SER A . n 
A 1 217 SER 217 217 217 SER SER A . n 
A 1 218 CYS 218 218 218 CYS CYS A . n 
A 1 219 LEU 219 219 219 LEU LEU A . n 
A 1 220 LEU 220 220 220 LEU LEU A . n 
A 1 221 LYS 221 221 221 LYS LYS A . n 
A 1 222 LEU 222 222 222 LEU LEU A . n 
A 1 223 TYR 223 223 223 TYR TYR A . n 
A 1 224 LYS 224 224 224 LYS LYS A . n 
A 1 225 LYS 225 225 225 LYS LYS A . n 
A 1 226 LEU 226 226 226 LEU LEU A . n 
A 1 227 LYS 227 227 227 LYS LYS A . n 
A 1 228 GLU 228 228 228 GLU GLU A . n 
A 1 229 GLU 229 229 229 GLU GLU A . n 
A 1 230 ILE 230 230 230 ILE ILE A . n 
A 1 231 LYS 231 231 231 LYS LYS A . n 
A 1 232 LYS 232 232 232 LYS LYS A . n 
A 1 233 GLU 233 233 233 GLU GLU A . n 
A 1 234 ASN 234 234 234 ASN ASN A . n 
A 1 235 LEU 235 235 235 LEU LEU A . n 
A 1 236 HIS 236 236 236 HIS HIS A . n 
A 1 237 ILE 237 237 237 ILE ILE A . n 
A 1 238 VAL 238 238 238 VAL VAL A . n 
A 1 239 ASN 239 239 239 ASN ASN A . n 
A 1 240 ASP 240 240 240 ASP ASP A . n 
A 1 241 ILE 241 241 241 ILE ILE A . n 
A 1 242 GLU 242 242 242 GLU GLU A . n 
A 1 243 ASN 243 243 243 ASN ASN A . n 
A 1 244 LYS 244 244 244 LYS LYS A . n 
A 1 245 CYS 245 245 245 CYS CYS A . n 
A 1 246 ILE 246 246 246 ILE ILE A . n 
A 1 247 LEU 247 247 247 LEU LEU A . n 
A 1 248 PRO 248 248 248 PRO PRO A . n 
A 1 249 ILE 249 249 249 ILE ILE A . n 
A 1 250 CYS 250 250 250 CYS CYS A . n 
A 1 251 ASP 251 251 251 ASP ASP A . n 
A 1 252 MET 252 252 252 MET MET A . n 
A 1 253 GLU 253 253 253 GLU GLU A . n 
A 1 254 LEU 254 254 254 LEU LEU A . n 
A 1 255 ASN 255 255 255 ASN ASN A . n 
A 1 256 GLY 256 256 256 GLY GLY A . n 
A 1 257 ILE 257 257 257 ILE ILE A . n 
A 1 258 LYS 258 258 258 LYS LYS A . n 
A 1 259 VAL 259 259 259 VAL VAL A . n 
A 1 260 ASP 260 260 260 ASP ASP A . n 
A 1 261 LEU 261 261 261 LEU LEU A . n 
A 1 262 GLU 262 262 262 GLU GLU A . n 
A 1 263 ASN 263 263 263 ASN ASN A . n 
A 1 264 LEU 264 264 264 LEU LEU A . n 
A 1 265 GLN 265 265 265 GLN GLN A . n 
A 1 266 LYS 266 266 266 LYS LYS A . n 
A 1 267 SER 267 267 267 SER SER A . n 
A 1 268 THR 268 268 268 THR THR A . n 
A 1 269 ASN 269 269 269 ASN ASN A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 ILE 271 271 271 ILE ILE A . n 
A 1 272 LEU 272 272 272 LEU LEU A . n 
A 1 273 ASN 273 273 273 ASN ASN A . n 
A 1 274 GLU 274 274 274 GLU GLU A . n 
A 1 275 LEU 275 275 275 LEU LEU A . n 
A 1 276 ASN 276 276 276 ASN ASN A . n 
A 1 277 ILE 277 277 277 ILE ILE A . n 
A 1 278 GLU 278 278 278 GLU GLU A . n 
A 1 279 LYS 279 279 279 LYS LYS A . n 
A 1 280 ASP 280 280 280 ASP ASP A . n 
A 1 281 ASN 281 281 281 ASN ASN A . n 
A 1 282 LEU 282 282 282 LEU LEU A . n 
A 1 283 LYS 283 283 283 LYS LYS A . n 
A 1 284 LYS 284 284 284 LYS LYS A . n 
A 1 285 LYS 285 285 285 LYS LYS A . n 
A 1 286 LEU 286 286 286 LEU LEU A . n 
A 1 287 LYS 287 287 287 LYS LYS A . n 
A 1 288 ASP 288 288 288 ASP ASP A . n 
A 1 289 GLU 289 289 289 GLU GLU A . n 
A 1 290 ASN 290 290 290 ASN ASN A . n 
A 1 291 ILE 291 291 291 ILE ILE A . n 
A 1 292 ASN 292 292 292 ASN ASN A . n 
A 1 293 VAL 293 293 293 VAL VAL A . n 
A 1 294 ASN 294 294 294 ASN ASN A . n 
A 1 295 SER 295 295 295 SER SER A . n 
A 1 296 GLN 296 296 296 GLN GLN A . n 
A 1 297 GLN 297 297 297 GLN GLN A . n 
A 1 298 GLN 298 298 298 GLN GLN A . n 
A 1 299 VAL 299 299 299 VAL VAL A . n 
A 1 300 LEU 300 300 300 LEU LEU A . n 
A 1 301 LYS 301 301 301 LYS LYS A . n 
A 1 302 ALA 302 302 302 ALA ALA A . n 
A 1 303 LEU 303 303 303 LEU LEU A . n 
A 1 304 GLN 304 304 304 GLN GLN A . n 
A 1 305 LYS 305 305 305 LYS LYS A . n 
A 1 306 ASN 306 306 306 ASN ASN A . n 
A 1 307 ASN 307 307 307 ASN ASN A . n 
A 1 308 VAL 308 308 308 VAL VAL A . n 
A 1 309 ARG 309 309 309 ARG ARG A . n 
A 1 310 ASP 310 310 310 ASP ASP A . n 
A 1 311 ILE 311 311 311 ILE ILE A . n 
A 1 312 SER 312 312 312 SER SER A . n 
A 1 313 ASN 313 313 313 ASN ASN A . n 
A 1 314 LYS 314 314 314 LYS LYS A . n 
A 1 315 LEU 315 315 315 LEU LEU A . n 
A 1 316 ILE 316 316 316 ILE ILE A . n 
A 1 317 GLU 317 317 317 GLU GLU A . n 
A 1 318 ASN 318 318 318 ASN ASN A . n 
A 1 319 THR 319 319 319 THR THR A . n 
A 1 320 SER 320 320 320 SER SER A . n 
A 1 321 ASP 321 321 321 ASP ASP A . n 
A 1 322 SER 322 322 322 SER SER A . n 
A 1 323 ASN 323 323 323 ASN ASN A . n 
A 1 324 LEU 324 324 324 LEU LEU A . n 
A 1 325 LYS 325 325 325 LYS LYS A . n 
A 1 326 ASN 326 326 326 ASN ASN A . n 
A 1 327 PHE 327 327 327 PHE PHE A . n 
A 1 328 LEU 328 328 328 LEU LEU A . n 
A 1 329 ASN 329 329 329 ASN ASN A . n 
A 1 330 HIS 330 330 330 HIS HIS A . n 
A 1 331 GLU 331 331 331 GLU GLU A . n 
A 1 332 GLU 332 332 332 GLU GLU A . n 
A 1 333 ILE 333 333 333 ILE ILE A . n 
A 1 334 ILE 334 334 334 ILE ILE A . n 
A 1 335 SER 335 335 335 SER SER A . n 
A 1 336 LEU 336 336 336 LEU LEU A . n 
A 1 337 ARG 337 337 337 ARG ARG A . n 
A 1 338 ASN 338 338 338 ASN ASN A . n 
A 1 339 TYR 339 339 339 TYR TYR A . n 
A 1 340 ARG 340 340 340 ARG ARG A . n 
A 1 341 ARG 341 341 341 ARG ARG A . n 
A 1 342 LEU 342 342 342 LEU LEU A . n 
A 1 343 TYR 343 343 343 TYR TYR A . n 
A 1 344 LYS 344 344 344 LYS LYS A . n 
A 1 345 LEU 345 345 345 LEU LEU A . n 
A 1 346 TYR 346 346 346 TYR TYR A . n 
A 1 347 SER 347 347 347 SER SER A . n 
A 1 348 ALA 348 348 348 ALA ALA A . n 
A 1 349 PHE 349 349 349 PHE PHE A . n 
A 1 350 TYR 350 350 350 TYR TYR A . n 
A 1 351 LEU 351 351 351 LEU LEU A . n 
A 1 352 LYS 352 352 352 LYS LYS A . n 
A 1 353 LEU 353 353 353 LEU LEU A . n 
A 1 354 PRO 354 354 354 PRO PRO A . n 
A 1 355 LEU 355 355 355 LEU LEU A . n 
A 1 356 HIS 356 356 356 HIS HIS A . n 
A 1 357 ILE 357 357 357 ILE ILE A . n 
A 1 358 ASN 358 358 358 ASN ASN A . n 
A 1 359 THR 359 359 359 THR THR A . n 
A 1 360 LYS 360 360 360 LYS LYS A . n 
A 1 361 THR 361 361 361 THR THR A . n 
A 1 362 ASN 362 362 362 ASN ASN A . n 
A 1 363 LYS 363 363 363 LYS LYS A . n 
A 1 364 ILE 364 364 364 ILE ILE A . n 
A 1 365 HIS 365 365 365 HIS HIS A . n 
A 1 366 THR 366 366 366 THR THR A . n 
A 1 367 THR 367 367 367 THR THR A . n 
A 1 368 PHE 368 368 368 PHE PHE A . n 
A 1 369 ASN 369 369 369 ASN ASN A . n 
A 1 370 GLN 370 370 370 GLN GLN A . n 
A 1 371 LEU 371 371 371 LEU LEU A . n 
A 1 372 LYS 372 372 372 LYS LYS A . n 
A 1 373 THR 373 373 373 THR THR A . n 
A 1 374 PHE 374 374 374 PHE PHE A . n 
A 1 375 SER 375 375 375 SER SER A . n 
A 1 376 GLY 376 376 376 GLY GLY A . n 
A 1 377 ARG 377 377 377 ARG ARG A . n 
A 1 378 PHE 378 378 378 PHE PHE A . n 
A 1 379 SER 379 379 379 SER SER A . n 
A 1 380 SER 380 380 380 SER SER A . n 
A 1 381 GLU 381 381 381 GLU GLU A . n 
A 1 382 LYS 382 382 382 LYS LYS A . n 
A 1 383 PRO 383 383 ?   ?   ?   A . n 
A 1 384 ASN 384 384 ?   ?   ?   A . n 
A 1 385 LEU 385 385 385 LEU LEU A . n 
A 1 386 GLN 386 386 386 GLN GLN A . n 
A 1 387 GLN 387 387 387 GLN GLN A . n 
A 1 388 ILE 388 388 388 ILE ILE A . n 
A 1 389 PRO 389 389 389 PRO PRO A . n 
A 1 390 ARG 390 390 390 ARG ARG A . n 
A 1 391 GLN 391 391 391 GLN GLN A . n 
A 1 392 LYS 392 392 392 LYS LYS A . n 
A 1 393 ASN 393 393 393 ASN ASN A . n 
A 1 394 ILE 394 394 394 ILE ILE A . n 
A 1 395 ARG 395 395 395 ARG ARG A . n 
A 1 396 GLU 396 396 396 GLU GLU A . n 
A 1 397 ILE 397 397 397 ILE ILE A . n 
A 1 398 PHE 398 398 398 PHE PHE A . n 
A 1 399 ILE 399 399 399 ILE ILE A . n 
A 1 400 PRO 400 400 400 PRO PRO A . n 
A 1 401 ASN 401 401 401 ASN ASN A . n 
A 1 402 ASP 402 402 402 ASP ASP A . n 
A 1 403 ASN 403 403 403 ASN ASN A . n 
A 1 404 ASN 404 404 404 ASN ASN A . n 
A 1 405 ILE 405 405 405 ILE ILE A . n 
A 1 406 PHE 406 406 406 PHE PHE A . n 
A 1 407 ILE 407 407 407 ILE ILE A . n 
A 1 408 ILE 408 408 408 ILE ILE A . n 
A 1 409 ALA 409 409 409 ALA ALA A . n 
A 1 410 ASP 410 410 410 ASP ASP A . n 
A 1 411 PHE 411 411 411 PHE PHE A . n 
A 1 412 LYS 412 412 412 LYS LYS A . n 
A 1 413 GLN 413 413 413 GLN GLN A . n 
A 1 414 ILE 414 414 414 ILE ILE A . n 
A 1 415 GLU 415 415 415 GLU GLU A . n 
A 1 416 LEU 416 416 416 LEU LEU A . n 
A 1 417 LYS 417 417 417 LYS LYS A . n 
A 1 418 ILE 418 418 418 ILE ILE A . n 
A 1 419 ALA 419 419 419 ALA ALA A . n 
A 1 420 ALA 420 420 420 ALA ALA A . n 
A 1 421 GLU 421 421 421 GLU GLU A . n 
A 1 422 ILE 422 422 ?   ?   ?   A . n 
A 1 423 THR 423 423 ?   ?   ?   A . n 
A 1 424 ASN 424 424 ?   ?   ?   A . n 
A 1 425 ASP 425 425 425 ASP ASP A . n 
A 1 426 GLU 426 426 426 GLU GLU A . n 
A 1 427 ILE 427 427 427 ILE ILE A . n 
A 1 428 MET 428 428 428 MET MET A . n 
A 1 429 LEU 429 429 429 LEU LEU A . n 
A 1 430 LYS 430 430 430 LYS LYS A . n 
A 1 431 ALA 431 431 431 ALA ALA A . n 
A 1 432 TYR 432 432 432 TYR TYR A . n 
A 1 433 ASN 433 433 433 ASN ASN A . n 
A 1 434 ASN 434 434 434 ASN ASN A . n 
A 1 435 ASN 435 435 435 ASN ASN A . n 
A 1 436 ILE 436 436 436 ILE ILE A . n 
A 1 437 ASP 437 437 437 ASP ASP A . n 
A 1 438 LEU 438 438 438 LEU LEU A . n 
A 1 439 HIS 439 439 439 HIS HIS A . n 
A 1 440 THR 440 440 440 THR THR A . n 
A 1 441 LEU 441 441 441 LEU LEU A . n 
A 1 442 THR 442 442 442 THR THR A . n 
A 1 443 ALA 443 443 443 ALA ALA A . n 
A 1 444 SER 444 444 444 SER SER A . n 
A 1 445 ILE 445 445 445 ILE ILE A . n 
A 1 446 ILE 446 446 446 ILE ILE A . n 
A 1 447 THR 447 447 447 THR THR A . n 
A 1 448 LYS 448 448 448 LYS LYS A . n 
A 1 449 LYS 449 449 449 LYS LYS A . n 
A 1 450 ASN 450 450 450 ASN ASN A . n 
A 1 451 ILE 451 451 451 ILE ILE A . n 
A 1 452 PRO 452 452 452 PRO PRO A . n 
A 1 453 ASP 453 453 453 ASP ASP A . n 
A 1 454 ILE 454 454 454 ILE ILE A . n 
A 1 455 ASN 455 455 455 ASN ASN A . n 
A 1 456 LYS 456 456 456 LYS LYS A . n 
A 1 457 GLU 457 457 457 GLU GLU A . n 
A 1 458 ASP 458 458 458 ASP ASP A . n 
A 1 459 ARG 459 459 459 ARG ARG A . n 
A 1 460 HIS 460 460 460 HIS HIS A . n 
A 1 461 ILE 461 461 461 ILE ILE A . n 
A 1 462 ALA 462 462 462 ALA ALA A . n 
A 1 463 LYS 463 463 463 LYS LYS A . n 
A 1 464 ALA 464 464 464 ALA ALA A . n 
A 1 465 ILE 465 465 465 ILE ILE A . n 
A 1 466 ASN 466 466 466 ASN ASN A . n 
A 1 467 PHE 467 467 467 PHE PHE A . n 
A 1 468 GLY 468 468 468 GLY GLY A . n 
A 1 469 LEU 469 469 469 LEU LEU A . n 
A 1 470 ILE 470 470 470 ILE ILE A . n 
A 1 471 TYR 471 471 471 TYR TYR A . n 
A 1 472 GLY 472 472 472 GLY GLY A . n 
A 1 473 MET 473 473 473 MET MET A . n 
A 1 474 ASN 474 474 474 ASN ASN A . n 
A 1 475 TYR 475 475 475 TYR TYR A . n 
A 1 476 VAL 476 476 476 VAL VAL A . n 
A 1 477 ASN 477 477 477 ASN ASN A . n 
A 1 478 LEU 478 478 478 LEU LEU A . n 
A 1 479 LYS 479 479 479 LYS LYS A . n 
A 1 480 ASN 480 480 480 ASN ASN A . n 
A 1 481 TYR 481 481 481 TYR TYR A . n 
A 1 482 ALA 482 482 482 ALA ALA A . n 
A 1 483 ASN 483 483 483 ASN ASN A . n 
A 1 484 THR 484 484 484 THR THR A . n 
A 1 485 TYR 485 485 485 TYR TYR A . n 
A 1 486 TYR 486 486 486 TYR TYR A . n 
A 1 487 GLY 487 487 487 GLY GLY A . n 
A 1 488 LEU 488 488 488 LEU LEU A . n 
A 1 489 ASN 489 489 489 ASN ASN A . n 
A 1 490 MET 490 490 490 MET MET A . n 
A 1 491 SER 491 491 491 SER SER A . n 
A 1 492 LEU 492 492 492 LEU LEU A . n 
A 1 493 ASP 493 493 493 ASP ASP A . n 
A 1 494 GLN 494 494 494 GLN GLN A . n 
A 1 495 CYS 495 495 495 CYS CYS A . n 
A 1 496 LEU 496 496 496 LEU LEU A . n 
A 1 497 TYR 497 497 497 TYR TYR A . n 
A 1 498 PHE 498 498 498 PHE PHE A . n 
A 1 499 TYR 499 499 499 TYR TYR A . n 
A 1 500 ASN 500 500 500 ASN ASN A . n 
A 1 501 SER 501 501 501 SER SER A . n 
A 1 502 PHE 502 502 ?   ?   ?   A . n 
A 1 503 PHE 503 503 ?   ?   ?   A . n 
A 1 504 GLU 504 504 ?   ?   ?   A . n 
A 1 505 HIS 505 505 ?   ?   ?   A . n 
A 1 506 TYR 506 506 ?   ?   ?   A . n 
A 1 507 LYS 507 507 507 LYS LYS A . n 
A 1 508 GLY 508 508 508 GLY GLY A . n 
A 1 509 ILE 509 509 509 ILE ILE A . n 
A 1 510 TYR 510 510 510 TYR TYR A . n 
A 1 511 LYS 511 511 511 LYS LYS A . n 
A 1 512 TRP 512 512 512 TRP TRP A . n 
A 1 513 HIS 513 513 513 HIS HIS A . n 
A 1 514 ASN 514 514 514 ASN ASN A . n 
A 1 515 GLN 515 515 515 GLN GLN A . n 
A 1 516 VAL 516 516 516 VAL VAL A . n 
A 1 517 LYS 517 517 517 LYS LYS A . n 
A 1 518 GLN 518 518 518 GLN GLN A . n 
A 1 519 LYS 519 519 519 LYS LYS A . n 
A 1 520 ARG 520 520 520 ARG ARG A . n 
A 1 521 ALA 521 521 521 ALA ALA A . n 
A 1 522 LEU 522 522 522 LEU LEU A . n 
A 1 523 GLN 523 523 523 GLN GLN A . n 
A 1 524 TYR 524 524 524 TYR TYR A . n 
A 1 525 SER 525 525 525 SER SER A . n 
A 1 526 THR 526 526 526 THR THR A . n 
A 1 527 LEU 527 527 527 LEU LEU A . n 
A 1 528 SER 528 528 528 SER SER A . n 
A 1 529 ASN 529 529 529 ASN ASN A . n 
A 1 530 ARG 530 530 530 ARG ARG A . n 
A 1 531 LYS 531 531 531 LYS LYS A . n 
A 1 532 VAL 532 532 532 VAL VAL A . n 
A 1 533 ILE 533 533 533 ILE ILE A . n 
A 1 534 PHE 534 534 534 PHE PHE A . n 
A 1 535 PRO 535 535 535 PRO PRO A . n 
A 1 536 TYR 536 536 536 TYR TYR A . n 
A 1 537 PHE 537 537 537 PHE PHE A . n 
A 1 538 SER 538 538 538 SER SER A . n 
A 1 539 PHE 539 539 539 PHE PHE A . n 
A 1 540 THR 540 540 540 THR THR A . n 
A 1 541 LYS 541 541 541 LYS LYS A . n 
A 1 542 ALA 542 542 542 ALA ALA A . n 
A 1 543 LEU 543 543 543 LEU LEU A . n 
A 1 544 ASN 544 544 544 ASN ASN A . n 
A 1 545 TYR 545 545 545 TYR TYR A . n 
A 1 546 PRO 546 546 546 PRO PRO A . n 
A 1 547 VAL 547 547 547 VAL VAL A . n 
A 1 548 GLN 548 548 548 GLN GLN A . n 
A 1 549 GLY 549 549 549 GLY GLY A . n 
A 1 550 THR 550 550 550 THR THR A . n 
A 1 551 CYS 551 551 551 CYS CYS A . n 
A 1 552 ALA 552 552 552 ALA ALA A . n 
A 1 553 ASP 553 553 553 ASP ASP A . n 
A 1 554 ILE 554 554 554 ILE ILE A . n 
A 1 555 LEU 555 555 555 LEU LEU A . n 
A 1 556 LYS 556 556 556 LYS LYS A . n 
A 1 557 LEU 557 557 557 LEU LEU A . n 
A 1 558 ALA 558 558 558 ALA ALA A . n 
A 1 559 LEU 559 559 559 LEU LEU A . n 
A 1 560 VAL 560 560 560 VAL VAL A . n 
A 1 561 ASP 561 561 561 ASP ASP A . n 
A 1 562 LEU 562 562 562 LEU LEU A . n 
A 1 563 TYR 563 563 563 TYR TYR A . n 
A 1 564 ASP 564 564 564 ASP ASP A . n 
A 1 565 ASN 565 565 565 ASN ASN A . n 
A 1 566 LEU 566 566 566 LEU LEU A . n 
A 1 567 LYS 567 567 567 LYS LYS A . n 
A 1 568 ASP 568 568 568 ASP ASP A . n 
A 1 569 ILE 569 569 569 ILE ILE A . n 
A 1 570 ASN 570 570 570 ASN ASN A . n 
A 1 571 GLY 571 571 571 GLY GLY A . n 
A 1 572 LYS 572 572 572 LYS LYS A . n 
A 1 573 ILE 573 573 573 ILE ILE A . n 
A 1 574 ILE 574 574 574 ILE ILE A . n 
A 1 575 LEU 575 575 575 LEU LEU A . n 
A 1 576 CYS 576 576 576 CYS CYS A . n 
A 1 577 VAL 577 577 577 VAL VAL A . n 
A 1 578 HIS 578 578 578 HIS HIS A . n 
A 1 579 ASP 579 579 579 ASP ASP A . n 
A 1 580 GLU 580 580 580 GLU GLU A . n 
A 1 581 ILE 581 581 581 ILE ILE A . n 
A 1 582 ILE 582 582 582 ILE ILE A . n 
A 1 583 ILE 583 583 583 ILE ILE A . n 
A 1 584 GLU 584 584 584 GLU GLU A . n 
A 1 585 VAL 585 585 585 VAL VAL A . n 
A 1 586 ASN 586 586 586 ASN ASN A . n 
A 1 587 LYS 587 587 587 LYS LYS A . n 
A 1 588 LYS 588 588 588 LYS LYS A . n 
A 1 589 PHE 589 589 589 PHE PHE A . n 
A 1 590 GLN 590 590 590 GLN GLN A . n 
A 1 591 GLU 591 591 591 GLU GLU A . n 
A 1 592 GLU 592 592 592 GLU GLU A . n 
A 1 593 ALA 593 593 593 ALA ALA A . n 
A 1 594 LEU 594 594 594 LEU LEU A . n 
A 1 595 LYS 595 595 595 LYS LYS A . n 
A 1 596 ILE 596 596 596 ILE ILE A . n 
A 1 597 LEU 597 597 597 LEU LEU A . n 
A 1 598 VAL 598 598 598 VAL VAL A . n 
A 1 599 GLN 599 599 599 GLN GLN A . n 
A 1 600 SER 600 600 600 SER SER A . n 
A 1 601 MET 601 601 601 MET MET A . n 
A 1 602 GLU 602 602 602 GLU GLU A . n 
A 1 603 ASN 603 603 603 ASN ASN A . n 
A 1 604 SER 604 604 604 SER SER A . n 
A 1 605 ALA 605 605 605 ALA ALA A . n 
A 1 606 SER 606 606 606 SER SER A . n 
A 1 607 TYR 607 607 607 TYR TYR A . n 
A 1 608 PHE 608 608 608 PHE PHE A . n 
A 1 609 LEU 609 609 609 LEU LEU A . n 
A 1 610 LYS 610 610 610 LYS LYS A . n 
A 1 611 LYS 611 611 611 LYS LYS A . n 
A 1 612 VAL 612 612 612 VAL VAL A . n 
A 1 613 LYS 613 613 613 LYS LYS A . n 
A 1 614 CYS 614 614 614 CYS CYS A . n 
A 1 615 GLU 615 615 615 GLU GLU A . n 
A 1 616 VAL 616 616 616 VAL VAL A . n 
A 1 617 SER 617 617 617 SER SER A . n 
A 1 618 VAL 618 618 618 VAL VAL A . n 
A 1 619 LYS 619 619 619 LYS LYS A . n 
A 1 620 ILE 620 620 620 ILE ILE A . n 
A 1 621 ALA 621 621 621 ALA ALA A . n 
A 1 622 GLU 622 622 622 GLU GLU A . n 
A 1 623 ASN 623 623 623 ASN ASN A . n 
A 1 624 TRP 624 624 624 TRP TRP A . n 
A 1 625 GLY 625 625 625 GLY GLY A . n 
A 1 626 SER 626 626 626 SER SER A . n 
A 1 627 LYS 627 627 627 LYS LYS A . n 
A 1 628 ASP 628 628 628 ASP ASP A . n 
B 2 1   DG  1   1   ?   ?   ?   E . n 
B 2 2   DC  2   2   ?   ?   ?   E . n 
B 2 3   DA  3   3   ?   ?   ?   E . n 
B 2 4   DG  4   4   ?   ?   ?   E . n 
B 2 5   DT  5   5   ?   ?   ?   E . n 
B 2 6   DC  6   6   ?   ?   ?   E . n 
B 2 7   DA  7   7   ?   ?   ?   E . n 
B 2 8   DG  8   8   ?   ?   ?   E . n 
B 2 9   DC  9   9   9   DC  DC  E . n 
B 2 10  DT  10  10  10  DT  DT  E . n 
B 2 11  DC  11  11  11  DC  DC  E . n 
B 2 12  DT  12  12  12  DT  DT  E . n 
B 2 13  DA  13  13  13  DA  DA  E . n 
B 2 14  DC  14  14  14  DC  DC  E . n 
B 2 15  DG  15  15  15  DG  DG  E . n 
B 2 16  DG  16  16  16  DG  DG  E . n 
B 2 17  DA  17  17  17  DA  DA  E . n 
B 2 18  DT  18  18  18  DT  DT  E . n 
B 2 19  DG  19  19  19  DG  DG  E . n 
B 2 20  DC  20  20  20  DC  DC  E . n 
B 2 21  DC  21  21  21  DC  DC  E . n 
B 2 22  DT  22  22  22  DT  DT  E . n 
B 2 23  DC  23  23  23  DC  DC  E . n 
B 2 24  DA  24  24  24  DA  DA  E . n 
B 2 25  DC  25  25  25  DC  DC  E . n 
B 2 26  DA  26  26  26  DA  DA  E . n 
B 2 27  DG  27  27  27  DG  DG  E . n 
B 2 28  DC  28  28  ?   ?   ?   E . n 
B 2 29  DA  29  29  ?   ?   ?   E . n 
C 3 1   DT  1   1   ?   ?   ?   F . n 
C 3 2   DA  2   2   2   DA  DA  F . n 
C 3 3   DC  3   3   3   DC  DC  F . n 
C 3 4   DT  4   4   4   DT  DT  F . n 
C 3 5   DG  5   5   5   DG  DG  F . n 
C 3 6   DT  6   6   6   DT  DT  F . n 
C 3 7   DG  7   7   7   DG  DG  F . n 
C 3 8   DA  8   8   8   DA  DA  F . n 
C 3 9   DG  9   9   9   DG  DG  F . n 
C 3 10  DG  10  10  10  DG  DG  F . n 
C 3 11  DC  11  11  11  DC  DC  F . n 
C 3 12  DA  12  12  12  DA  DA  F . n 
C 3 13  DT  13  13  13  DT  DT  F . n 
C 3 14  DC  14  14  14  DC  DC  F . n 
C 3 15  DC  15  15  15  DC  DC  F . n 
C 3 16  DG  16  16  16  DG  DG  F . n 
C 3 17  DT  17  17  17  DT  DT  F . n 
C 3 18  DA  18  18  18  DA  DA  F . n 
C 3 19  DG  19  19  19  DG  DG  F . n 
C 3 20  2DA 20  20  20  2DA 2DA F . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 F DA 2 ? P     ? C DA 2 P     
2  1 Y 1 F DA 2 ? OP1   ? C DA 2 OP1   
3  1 Y 1 F DA 2 ? OP2   ? C DA 2 OP2   
4  1 Y 1 F DA 2 ? "O5'" ? C DA 2 "O5'" 
5  1 Y 1 F DA 2 ? "C5'" ? C DA 2 "C5'" 
6  1 Y 1 F DA 2 ? "C4'" ? C DA 2 "C4'" 
7  1 Y 1 F DA 2 ? "O4'" ? C DA 2 "O4'" 
8  1 Y 1 F DA 2 ? "C3'" ? C DA 2 "C3'" 
9  1 Y 1 F DA 2 ? "C2'" ? C DA 2 "C2'" 
10 1 Y 1 F DA 2 ? "C1'" ? C DA 2 "C1'" 
11 1 Y 1 F DA 2 ? N9    ? C DA 2 N9    
12 1 Y 1 F DA 2 ? C8    ? C DA 2 C8    
13 1 Y 1 F DA 2 ? N7    ? C DA 2 N7    
14 1 Y 1 F DA 2 ? C5    ? C DA 2 C5    
15 1 Y 1 F DA 2 ? C6    ? C DA 2 C6    
16 1 Y 1 F DA 2 ? N6    ? C DA 2 N6    
17 1 Y 1 F DA 2 ? N1    ? C DA 2 N1    
18 1 Y 1 F DA 2 ? C2    ? C DA 2 C2    
19 1 Y 1 F DA 2 ? N3    ? C DA 2 N3    
20 1 Y 1 F DA 2 ? C4    ? C DA 2 C4    
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DG1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DG1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DG1 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9DG1 
_struct.title                        'Structure of Plasmodium falciparum apicoplast DNA polymerase in complex with DNA (exo-minus)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DG1 
_struct_keywords.text            'DNA polymerase, DNA BINDING PROTEIN, DNA BINDING PROTEIN-DNA complex' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN/DNA' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP Q8ILY1_PLAF7 Q8ILY1 ? 1 
;DEITKKYIKDNIINVDDNIIKKKDIFKLKNENNEITECAFEYFESKKKFDDDIESRFFIINDNNYNENINLIYKDIKYCG
LDIETTGLEVFDENIRLIQIAVENYPVIIYDMFNINKKDILDGLRKVLENKNIIKIIQNGKFDAKFLLHNNFKIENIFDT
YIASKLLDKNKNMYGFKLNNIVEKYLNVILDKQQQNSVWNNSLLNNNQLFYAARDSSCLLKLYKKLKEEIKKENLHIVND
IENKCILPICDMELNGIKVDLENLQKSTNEILNELNIEKDNLKKKLKDENINVNSQQQVLKALQKNNVRDISNKLIENTS
DSNLKNFLNHEEIISLRNYRRLYKLYSAFYLKLPLHINTKTNKIHTTFNQLKTFSGRFSSEKPNLQQIPRQKNIREIFIP
NDNNIFIIADFKQIELKIAAEITNDEIMLKAYNNNIDLHTLTASIITKKNIPDINKEDRHIAKAINFGLIYGMNYVNLKN
YANTYYGLNMSLDQCLYFYNSFFEHYKGIYKWHNQVKQKRALQYSTLSNRKVIFPYFSFTKALNYPVQGTCADILKLALV
DLYDNLKDINGKIILCVHDEIIIEVNKKFQEEALKILVQSMENSASYFLKKVKCEVSVKIAENWGSKD
;
1389 
2 PDB 9DG1         9DG1   ? 2 ? 1    
3 PDB 9DG1         9DG1   ? 3 ? 1    
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9DG1 A 1 ? 628 ? Q8ILY1 1389 ? 2016 ? 1 628 
2 2 9DG1 E 1 ? 29  ? 9DG1   1    ? 29   ? 1 29  
3 3 9DG1 F 1 ? 20  ? 9DG1   1    ? 20   ? 1 20  
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9DG1 ASN A 82 ? UNP Q8ILY1 ASP 1470 'engineered mutation' 82 1 
1 9DG1 GLN A 84 ? UNP Q8ILY1 GLU 1472 'engineered mutation' 84 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 66  ? LYS A 74  ? ASN A 66  LYS A 74  5 ? 9  
HELX_P HELX_P2  AA2 PHE A 113 ? ILE A 115 ? PHE A 113 ILE A 115 5 ? 3  
HELX_P HELX_P3  AA3 LYS A 118 ? ASN A 130 ? LYS A 118 ASN A 130 1 ? 13 
HELX_P HELX_P4  AA4 ASN A 139 ? ASN A 150 ? ASN A 139 ASN A 150 1 ? 12 
HELX_P HELX_P5  AA5 THR A 160 ? LYS A 169 ? THR A 160 LYS A 169 1 ? 10 
HELX_P HELX_P6  AA6 LEU A 209 ? LYS A 232 ? LEU A 209 LYS A 232 1 ? 24 
HELX_P HELX_P7  AA7 LEU A 235 ? CYS A 245 ? LEU A 235 CYS A 245 1 ? 11 
HELX_P HELX_P8  AA8 CYS A 245 ? GLY A 256 ? CYS A 245 GLY A 256 1 ? 12 
HELX_P HELX_P9  AA9 ASP A 260 ? LEU A 286 ? ASP A 260 LEU A 286 1 ? 27 
HELX_P HELX_P10 AB1 SER A 295 ? ASN A 307 ? SER A 295 ASN A 307 1 ? 13 
HELX_P HELX_P11 AB2 SER A 320 ? LYS A 325 ? SER A 320 LYS A 325 1 ? 6  
HELX_P HELX_P12 AB3 ASN A 326 ? LEU A 328 ? ASN A 326 LEU A 328 5 ? 3  
HELX_P HELX_P13 AB4 HIS A 330 ? PHE A 349 ? HIS A 330 PHE A 349 1 ? 20 
HELX_P HELX_P14 AB5 LYS A 352 ? HIS A 356 ? LYS A 352 HIS A 356 5 ? 5  
HELX_P HELX_P15 AB6 GLN A 391 ? GLU A 396 ? GLN A 391 GLU A 396 1 ? 6  
HELX_P HELX_P16 AB7 GLN A 413 ? GLU A 421 ? GLN A 413 GLU A 421 1 ? 9  
HELX_P HELX_P17 AB8 GLU A 426 ? ASN A 434 ? GLU A 426 ASN A 434 1 ? 9  
HELX_P HELX_P18 AB9 ASP A 437 ? LYS A 448 ? ASP A 437 LYS A 448 1 ? 12 
HELX_P HELX_P19 AC1 ASN A 450 ? ILE A 454 ? ASN A 450 ILE A 454 5 ? 5  
HELX_P HELX_P20 AC2 ASN A 455 ? TYR A 471 ? ASN A 455 TYR A 471 1 ? 17 
HELX_P HELX_P21 AC3 ASN A 474 ? GLY A 487 ? ASN A 474 GLY A 487 1 ? 14 
HELX_P HELX_P22 AC4 SER A 491 ? SER A 501 ? SER A 491 SER A 501 1 ? 11 
HELX_P HELX_P23 AC5 GLY A 508 ? ARG A 520 ? GLY A 508 ARG A 520 1 ? 13 
HELX_P HELX_P24 AC6 SER A 538 ? LEU A 566 ? SER A 538 LEU A 566 1 ? 29 
HELX_P HELX_P25 AC7 LYS A 567 ? ASN A 570 ? LYS A 567 ASN A 570 5 ? 4  
HELX_P HELX_P26 AC8 PHE A 589 ? LEU A 609 ? PHE A 589 LEU A 609 1 ? 21 
HELX_P HELX_P27 AC9 ASN A 623 ? ASP A 628 ? ASN A 623 ASP A 628 5 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1  covale both ? C DG 19 "O3'" ? ? ? 1_555 C 2DA 20 P  ? ? F DG 19 F 2DA 20 1_555 ? ? ? ? ? ? ?                1.605 ? ? 
hydrog1  hydrog ?    ? B DT 10 O4    ? ? ? 1_555 C 2DA 20 N6 ? ? E DT 10 F 2DA 20 1_555 ? ? ? ? ? ? 'DT-2DA MISPAIR' ?     ? ? 
hydrog2  hydrog ?    ? B DC 11 N3    ? ? ? 1_555 C DG  19 N1 ? ? E DC 11 F DG  19 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog3  hydrog ?    ? B DC 11 N4    ? ? ? 1_555 C DG  19 O6 ? ? E DC 11 F DG  19 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog4  hydrog ?    ? B DC 11 O2    ? ? ? 1_555 C DG  19 N2 ? ? E DC 11 F DG  19 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog5  hydrog ?    ? B DT 12 N3    ? ? ? 1_555 C DA  18 N1 ? ? E DT 12 F DA  18 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog6  hydrog ?    ? B DT 12 O4    ? ? ? 1_555 C DA  18 N6 ? ? E DT 12 F DA  18 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog7  hydrog ?    ? B DA 13 N1    ? ? ? 1_555 C DT  17 N3 ? ? E DA 13 F DT  17 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog8  hydrog ?    ? B DA 13 N6    ? ? ? 1_555 C DT  17 O4 ? ? E DA 13 F DT  17 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog9  hydrog ?    ? B DC 14 N3    ? ? ? 1_555 C DG  16 N1 ? ? E DC 14 F DG  16 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog10 hydrog ?    ? B DC 14 N4    ? ? ? 1_555 C DG  16 O6 ? ? E DC 14 F DG  16 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog11 hydrog ?    ? B DC 14 O2    ? ? ? 1_555 C DG  16 N2 ? ? E DC 14 F DG  16 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog12 hydrog ?    ? B DG 15 O6    ? ? ? 1_555 C DC  15 N4 ? ? E DG 15 F DC  15 1_555 ? ? ? ? ? ? 'DG-DC PAIR'     ?     ? ? 
hydrog13 hydrog ?    ? B DG 15 O6    ? ? ? 1_555 C DG  16 N1 ? ? E DG 15 F DG  16 1_555 ? ? ? ? ? ? 'DG-DG MISPAIR'  ?     ? ? 
hydrog14 hydrog ?    ? B DG 16 N1    ? ? ? 1_555 C DC  15 N3 ? ? E DG 16 F DC  15 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog15 hydrog ?    ? B DG 16 N2    ? ? ? 1_555 C DC  15 O2 ? ? E DG 16 F DC  15 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog16 hydrog ?    ? B DG 16 O6    ? ? ? 1_555 C DC  15 N4 ? ? E DG 16 F DC  15 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog17 hydrog ?    ? B DA 17 N6    ? ? ? 1_555 C DT  13 O4 ? ? E DA 17 F DT  13 1_555 ? ? ? ? ? ? 'DA-DT PAIR'     ?     ? ? 
hydrog18 hydrog ?    ? B DA 17 N6    ? ? ? 1_555 C DC  14 N3 ? ? E DA 17 F DC  14 1_555 ? ? ? ? ? ? 'DA-DC MISPAIR'  ?     ? ? 
hydrog19 hydrog ?    ? B DT 18 N3    ? ? ? 1_555 C DA  12 N1 ? ? E DT 18 F DA  12 1_555 ? ? ? ? ? ? 'DT-DA PAIR'     ?     ? ? 
hydrog20 hydrog ?    ? B DG 19 O6    ? ? ? 1_555 C DC  11 N4 ? ? E DG 19 F DC  11 1_555 ? ? ? ? ? ? 'DG-DC PAIR'     ?     ? ? 
hydrog21 hydrog ?    ? B DC 20 N4    ? ? ? 1_555 C DG  10 O6 ? ? E DC 20 F DG  10 1_555 ? ? ? ? ? ? 'DC-DG PAIR'     ?     ? ? 
hydrog22 hydrog ?    ? B DC 21 N3    ? ? ? 1_555 C DG  10 N1 ? ? E DC 21 F DG  10 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog23 hydrog ?    ? B DC 21 N4    ? ? ? 1_555 C DG  10 O6 ? ? E DC 21 F DG  10 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog24 hydrog ?    ? B DC 21 O2    ? ? ? 1_555 C DG  10 N2 ? ? E DC 21 F DG  10 1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog25 hydrog ?    ? B DT 22 N3    ? ? ? 1_555 C DG  9  O6 ? ? E DT 22 F DG  9  1_555 ? ? ? ? ? ? TYPE_28_PAIR     ?     ? ? 
hydrog26 hydrog ?    ? B DT 22 O2    ? ? ? 1_555 C DG  9  N1 ? ? E DT 22 F DG  9  1_555 ? ? ? ? ? ? TYPE_28_PAIR     ?     ? ? 
hydrog27 hydrog ?    ? B DC 23 N4    ? ? ? 1_555 C DG  7  O6 ? ? E DC 23 F DG  7  1_555 ? ? ? ? ? ? 'DC-DG PAIR'     ?     ? ? 
hydrog28 hydrog ?    ? B DC 23 N3    ? ? ? 1_555 C DA  8  N6 ? ? E DC 23 F DA  8  1_555 ? ? ? ? ? ? 'DC-DA MISPAIR'  ?     ? ? 
hydrog29 hydrog ?    ? B DA 24 N1    ? ? ? 1_555 C DT  6  N3 ? ? E DA 24 F DT  6  1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog30 hydrog ?    ? B DA 24 N6    ? ? ? 1_555 C DT  6  O4 ? ? E DA 24 F DT  6  1_555 ? ? ? ? ? ? WATSON-CRICK     ?     ? ? 
hydrog31 hydrog ?    ? B DC 25 N3    ? ? ? 1_555 C DT  6  N3 ? ? E DC 25 F DT  6  1_555 ? ? ? ? ? ? TYPE_18_PAIR     ?     ? ? 
hydrog32 hydrog ?    ? B DC 25 N4    ? ? ? 1_555 C DT  6  O4 ? ? E DC 25 F DT  6  1_555 ? ? ? ? ? ? TYPE_18_PAIR     ?     ? ? 
hydrog33 hydrog ?    ? B DA 26 N6    ? ? ? 1_555 C DT  4  O4 ? ? E DA 26 F DT  4  1_555 ? ? ? ? ? ? 'DA-DT PAIR'     ?     ? ? 
hydrog34 hydrog ?    ? B DA 26 N1    ? ? ? 1_555 C DG  5  N1 ? ? E DA 26 F DG  5  1_555 ? ? ? ? ? ? TYPE_8_PAIR      ?     ? ? 
hydrog35 hydrog ?    ? B DA 26 N6    ? ? ? 1_555 C DG  5  O6 ? ? E DA 26 F DG  5  1_555 ? ? ? ? ? ? TYPE_8_PAIR      ?     ? ? 
hydrog36 hydrog ?    ? B DG 27 N1    ? ? ? 1_555 C DT  4  O2 ? ? E DG 27 F DT  4  1_555 ? ? ? ? ? ? TYPE_28_PAIR     ?     ? ? 
hydrog37 hydrog ?    ? B DG 27 O6    ? ? ? 1_555 C DT  4  N3 ? ? E DG 27 F DT  4  1_555 ? ? ? ? ? ? TYPE_28_PAIR     ?     ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
covale ? ? 
hydrog ? ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 4 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 57  ? ILE A 60  ? PHE A 57  ILE A 60  
AA1 2 VAL A 107 ? ASP A 111 ? VAL A 107 ASP A 111 
AA1 3 ILE A 95  ? ALA A 101 ? ILE A 95  ALA A 101 
AA1 4 TYR A 78  ? THR A 85  ? TYR A 78  THR A 85  
AA1 5 ILE A 134 ? ILE A 137 ? ILE A 134 ILE A 137 
AA1 6 ILE A 157 ? ASP A 159 ? ILE A 157 ASP A 159 
AA2 1 LYS A 363 ? ILE A 364 ? LYS A 363 ILE A 364 
AA2 2 ILE A 257 ? VAL A 259 ? ILE A 257 VAL A 259 
AA2 3 PHE A 398 ? ILE A 399 ? PHE A 398 ILE A 399 
AA3 1 THR A 367 ? ASN A 369 ? THR A 367 ASN A 369 
AA3 2 SER A 379 ? GLU A 381 ? SER A 379 GLU A 381 
AA4 1 LYS A 572 ? VAL A 577 ? LYS A 572 VAL A 577 
AA4 2 GLU A 580 ? ASN A 586 ? GLU A 580 ASN A 586 
AA4 3 ASN A 404 ? PHE A 411 ? ASN A 404 PHE A 411 
AA4 4 VAL A 616 ? ALA A 621 ? VAL A 616 ALA A 621 
AA5 1 GLN A 523 ? SER A 525 ? GLN A 523 SER A 525 
AA5 2 LYS A 531 ? ILE A 533 ? LYS A 531 ILE A 533 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N PHE A 58  ? N PHE A 58  O VAL A 107 ? O VAL A 107 
AA1 2 3 O ILE A 108 ? O ILE A 108 N ILE A 100 ? N ILE A 100 
AA1 3 4 O GLN A 99  ? O GLN A 99  N ASN A 82  ? N ASN A 82  
AA1 4 5 N LEU A 81  ? N LEU A 81  O ILE A 136 ? O ILE A 136 
AA1 5 6 N ILE A 137 ? N ILE A 137 O PHE A 158 ? O PHE A 158 
AA2 1 2 O ILE A 364 ? O ILE A 364 N ILE A 257 ? N ILE A 257 
AA2 2 3 N LYS A 258 ? N LYS A 258 O ILE A 399 ? O ILE A 399 
AA3 1 2 N THR A 367 ? N THR A 367 O GLU A 381 ? O GLU A 381 
AA4 1 2 N VAL A 577 ? N VAL A 577 O GLU A 580 ? O GLU A 580 
AA4 2 3 O ILE A 581 ? O ILE A 581 N ALA A 409 ? N ALA A 409 
AA4 3 4 N PHE A 406 ? N PHE A 406 O ALA A 621 ? O ALA A 621 
AA5 1 2 N TYR A 524 ? N TYR A 524 O VAL A 532 ? O VAL A 532 
# 
_pdbx_entry_details.entry_id                   9DG1 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 "C3'" F DA 18 ? ? "O3'" F DA 18 ? ? P F DG  19 ? ? 111.48 119.70 -8.22  1.20 Y 
2 1 "C3'" F DG 19 ? ? "O3'" F DG 19 ? ? P F 2DA 20 ? ? 109.36 119.70 -10.34 1.20 Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASN A 139 ? ? 67.15   67.35   
2  1 ASN A 156 ? ? 75.35   94.95   
3  1 ILE A 230 ? ? -72.19  -108.37 
4  1 ASN A 234 ? ? 61.91   -37.93  
5  1 HIS A 236 ? ? -26.94  -61.85  
6  1 ASP A 310 ? ? -79.80  -168.50 
7  1 PHE A 349 ? ? -124.62 -68.09  
8  1 THR A 359 ? ? -125.66 -58.43  
9  1 LYS A 360 ? ? -49.56  -16.20  
10 1 HIS A 578 ? ? 51.03   -119.83 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9DG1 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9DG1 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  5.2 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               270582 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.6 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Plasmodium falciparum apicoplast DNA polymerase-DNA binary complex' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3' 
# 
_em_imaging.entry_id                        9DG1 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             700 
_em_imaging.nominal_defocus_max             3000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9DG1 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   295 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9DG1 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A ASP 1   ? A ASP 1   
2   1 Y 1 A GLU 2   ? A GLU 2   
3   1 Y 1 A ILE 3   ? A ILE 3   
4   1 Y 1 A THR 4   ? A THR 4   
5   1 Y 1 A LYS 5   ? A LYS 5   
6   1 Y 1 A LYS 6   ? A LYS 6   
7   1 Y 1 A TYR 7   ? A TYR 7   
8   1 Y 1 A ILE 8   ? A ILE 8   
9   1 Y 1 A LYS 9   ? A LYS 9   
10  1 Y 1 A ASP 10  ? A ASP 10  
11  1 Y 1 A ASN 11  ? A ASN 11  
12  1 Y 1 A ILE 12  ? A ILE 12  
13  1 Y 1 A ILE 13  ? A ILE 13  
14  1 Y 1 A ASN 14  ? A ASN 14  
15  1 Y 1 A VAL 15  ? A VAL 15  
16  1 Y 1 A ASP 16  ? A ASP 16  
17  1 Y 1 A ASP 17  ? A ASP 17  
18  1 Y 1 A ASN 18  ? A ASN 18  
19  1 Y 1 A ILE 19  ? A ILE 19  
20  1 Y 1 A ILE 20  ? A ILE 20  
21  1 Y 1 A LYS 21  ? A LYS 21  
22  1 Y 1 A LYS 22  ? A LYS 22  
23  1 Y 1 A LYS 23  ? A LYS 23  
24  1 Y 1 A ASP 24  ? A ASP 24  
25  1 Y 1 A ILE 25  ? A ILE 25  
26  1 Y 1 A PHE 26  ? A PHE 26  
27  1 Y 1 A LYS 27  ? A LYS 27  
28  1 Y 1 A LEU 28  ? A LEU 28  
29  1 Y 1 A LYS 29  ? A LYS 29  
30  1 Y 1 A ASN 30  ? A ASN 30  
31  1 Y 1 A GLU 31  ? A GLU 31  
32  1 Y 1 A ASN 32  ? A ASN 32  
33  1 Y 1 A ASN 33  ? A ASN 33  
34  1 Y 1 A GLU 34  ? A GLU 34  
35  1 Y 1 A ILE 35  ? A ILE 35  
36  1 Y 1 A THR 36  ? A THR 36  
37  1 Y 1 A GLU 37  ? A GLU 37  
38  1 Y 1 A CYS 38  ? A CYS 38  
39  1 Y 1 A ALA 39  ? A ALA 39  
40  1 Y 1 A PHE 40  ? A PHE 40  
41  1 Y 1 A GLU 41  ? A GLU 41  
42  1 Y 1 A TYR 42  ? A TYR 42  
43  1 Y 1 A PHE 43  ? A PHE 43  
44  1 Y 1 A GLU 44  ? A GLU 44  
45  1 Y 1 A SER 45  ? A SER 45  
46  1 Y 1 A LYS 46  ? A LYS 46  
47  1 Y 1 A LYS 47  ? A LYS 47  
48  1 Y 1 A LYS 48  ? A LYS 48  
49  1 Y 1 A PHE 49  ? A PHE 49  
50  1 Y 1 A TYR 174 ? A TYR 174 
51  1 Y 1 A GLY 175 ? A GLY 175 
52  1 Y 1 A PHE 176 ? A PHE 176 
53  1 Y 1 A LYS 177 ? A LYS 177 
54  1 Y 1 A LEU 178 ? A LEU 178 
55  1 Y 1 A ASN 179 ? A ASN 179 
56  1 Y 1 A ASN 180 ? A ASN 180 
57  1 Y 1 A ILE 181 ? A ILE 181 
58  1 Y 1 A VAL 182 ? A VAL 182 
59  1 Y 1 A GLU 183 ? A GLU 183 
60  1 Y 1 A LYS 184 ? A LYS 184 
61  1 Y 1 A TYR 185 ? A TYR 185 
62  1 Y 1 A LEU 186 ? A LEU 186 
63  1 Y 1 A ASN 187 ? A ASN 187 
64  1 Y 1 A VAL 188 ? A VAL 188 
65  1 Y 1 A ILE 189 ? A ILE 189 
66  1 Y 1 A LEU 190 ? A LEU 190 
67  1 Y 1 A ASP 191 ? A ASP 191 
68  1 Y 1 A LYS 192 ? A LYS 192 
69  1 Y 1 A GLN 193 ? A GLN 193 
70  1 Y 1 A GLN 194 ? A GLN 194 
71  1 Y 1 A GLN 195 ? A GLN 195 
72  1 Y 1 A ASN 196 ? A ASN 196 
73  1 Y 1 A SER 197 ? A SER 197 
74  1 Y 1 A VAL 198 ? A VAL 198 
75  1 Y 1 A TRP 199 ? A TRP 199 
76  1 Y 1 A ASN 200 ? A ASN 200 
77  1 Y 1 A ASN 201 ? A ASN 201 
78  1 Y 1 A SER 202 ? A SER 202 
79  1 Y 1 A LEU 203 ? A LEU 203 
80  1 Y 1 A LEU 204 ? A LEU 204 
81  1 Y 1 A ASN 205 ? A ASN 205 
82  1 Y 1 A ASN 206 ? A ASN 206 
83  1 Y 1 A ASN 207 ? A ASN 207 
84  1 Y 1 A PRO 383 ? A PRO 383 
85  1 Y 1 A ASN 384 ? A ASN 384 
86  1 Y 1 A ILE 422 ? A ILE 422 
87  1 Y 1 A THR 423 ? A THR 423 
88  1 Y 1 A ASN 424 ? A ASN 424 
89  1 Y 1 A PHE 502 ? A PHE 502 
90  1 Y 1 A PHE 503 ? A PHE 503 
91  1 Y 1 A GLU 504 ? A GLU 504 
92  1 Y 1 A HIS 505 ? A HIS 505 
93  1 Y 1 A TYR 506 ? A TYR 506 
94  1 Y 1 E DG  1   ? B DG  1   
95  1 Y 1 E DC  2   ? B DC  2   
96  1 Y 1 E DA  3   ? B DA  3   
97  1 Y 1 E DG  4   ? B DG  4   
98  1 Y 1 E DT  5   ? B DT  5   
99  1 Y 1 E DC  6   ? B DC  6   
100 1 Y 1 E DA  7   ? B DA  7   
101 1 Y 1 E DG  8   ? B DG  8   
102 1 Y 1 E DC  28  ? B DC  28  
103 1 Y 1 E DA  29  ? B DA  29  
104 1 Y 1 F DT  1   ? C DT  1   
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
2DA P      P N N 1   
2DA OP1    O N N 2   
2DA OP2    O N N 3   
2DA OP3    O N N 4   
2DA "O5'"  O N N 5   
2DA "C5'"  C N N 6   
2DA "C4'"  C N S 7   
2DA "O4'"  O N N 8   
2DA "C3'"  C N N 9   
2DA "C2'"  C N N 10  
2DA "C1'"  C N R 11  
2DA N9     N Y N 12  
2DA C8     C Y N 13  
2DA N7     N Y N 14  
2DA C5     C Y N 15  
2DA C6     C Y N 16  
2DA N6     N N N 17  
2DA N1     N Y N 18  
2DA C2     C Y N 19  
2DA N3     N Y N 20  
2DA C4     C Y N 21  
2DA HOP2   H N N 22  
2DA HOP3   H N N 23  
2DA "H5'"  H N N 24  
2DA "H5''" H N N 25  
2DA "H4'"  H N N 26  
2DA "H3'1" H N N 27  
2DA "H3'2" H N N 28  
2DA "H2'"  H N N 29  
2DA "H2''" H N N 30  
2DA "H1'"  H N N 31  
2DA H8     H N N 32  
2DA HN61   H N N 33  
2DA HN62   H N N 34  
2DA H2     H N N 35  
ALA N      N N N 36  
ALA CA     C N S 37  
ALA C      C N N 38  
ALA O      O N N 39  
ALA CB     C N N 40  
ALA OXT    O N N 41  
ALA H      H N N 42  
ALA H2     H N N 43  
ALA HA     H N N 44  
ALA HB1    H N N 45  
ALA HB2    H N N 46  
ALA HB3    H N N 47  
ALA HXT    H N N 48  
ARG N      N N N 49  
ARG CA     C N S 50  
ARG C      C N N 51  
ARG O      O N N 52  
ARG CB     C N N 53  
ARG CG     C N N 54  
ARG CD     C N N 55  
ARG NE     N N N 56  
ARG CZ     C N N 57  
ARG NH1    N N N 58  
ARG NH2    N N N 59  
ARG OXT    O N N 60  
ARG H      H N N 61  
ARG H2     H N N 62  
ARG HA     H N N 63  
ARG HB2    H N N 64  
ARG HB3    H N N 65  
ARG HG2    H N N 66  
ARG HG3    H N N 67  
ARG HD2    H N N 68  
ARG HD3    H N N 69  
ARG HE     H N N 70  
ARG HH11   H N N 71  
ARG HH12   H N N 72  
ARG HH21   H N N 73  
ARG HH22   H N N 74  
ARG HXT    H N N 75  
ASN N      N N N 76  
ASN CA     C N S 77  
ASN C      C N N 78  
ASN O      O N N 79  
ASN CB     C N N 80  
ASN CG     C N N 81  
ASN OD1    O N N 82  
ASN ND2    N N N 83  
ASN OXT    O N N 84  
ASN H      H N N 85  
ASN H2     H N N 86  
ASN HA     H N N 87  
ASN HB2    H N N 88  
ASN HB3    H N N 89  
ASN HD21   H N N 90  
ASN HD22   H N N 91  
ASN HXT    H N N 92  
ASP N      N N N 93  
ASP CA     C N S 94  
ASP C      C N N 95  
ASP O      O N N 96  
ASP CB     C N N 97  
ASP CG     C N N 98  
ASP OD1    O N N 99  
ASP OD2    O N N 100 
ASP OXT    O N N 101 
ASP H      H N N 102 
ASP H2     H N N 103 
ASP HA     H N N 104 
ASP HB2    H N N 105 
ASP HB3    H N N 106 
ASP HD2    H N N 107 
ASP HXT    H N N 108 
CYS N      N N N 109 
CYS CA     C N R 110 
CYS C      C N N 111 
CYS O      O N N 112 
CYS CB     C N N 113 
CYS SG     S N N 114 
CYS OXT    O N N 115 
CYS H      H N N 116 
CYS H2     H N N 117 
CYS HA     H N N 118 
CYS HB2    H N N 119 
CYS HB3    H N N 120 
CYS HG     H N N 121 
CYS HXT    H N N 122 
DA  OP3    O N N 123 
DA  P      P N N 124 
DA  OP1    O N N 125 
DA  OP2    O N N 126 
DA  "O5'"  O N N 127 
DA  "C5'"  C N N 128 
DA  "C4'"  C N R 129 
DA  "O4'"  O N N 130 
DA  "C3'"  C N S 131 
DA  "O3'"  O N N 132 
DA  "C2'"  C N N 133 
DA  "C1'"  C N R 134 
DA  N9     N Y N 135 
DA  C8     C Y N 136 
DA  N7     N Y N 137 
DA  C5     C Y N 138 
DA  C6     C Y N 139 
DA  N6     N N N 140 
DA  N1     N Y N 141 
DA  C2     C Y N 142 
DA  N3     N Y N 143 
DA  C4     C Y N 144 
DA  HOP3   H N N 145 
DA  HOP2   H N N 146 
DA  "H5'"  H N N 147 
DA  "H5''" H N N 148 
DA  "H4'"  H N N 149 
DA  "H3'"  H N N 150 
DA  "HO3'" H N N 151 
DA  "H2'"  H N N 152 
DA  "H2''" H N N 153 
DA  "H1'"  H N N 154 
DA  H8     H N N 155 
DA  H61    H N N 156 
DA  H62    H N N 157 
DA  H2     H N N 158 
DC  OP3    O N N 159 
DC  P      P N N 160 
DC  OP1    O N N 161 
DC  OP2    O N N 162 
DC  "O5'"  O N N 163 
DC  "C5'"  C N N 164 
DC  "C4'"  C N R 165 
DC  "O4'"  O N N 166 
DC  "C3'"  C N S 167 
DC  "O3'"  O N N 168 
DC  "C2'"  C N N 169 
DC  "C1'"  C N R 170 
DC  N1     N N N 171 
DC  C2     C N N 172 
DC  O2     O N N 173 
DC  N3     N N N 174 
DC  C4     C N N 175 
DC  N4     N N N 176 
DC  C5     C N N 177 
DC  C6     C N N 178 
DC  HOP3   H N N 179 
DC  HOP2   H N N 180 
DC  "H5'"  H N N 181 
DC  "H5''" H N N 182 
DC  "H4'"  H N N 183 
DC  "H3'"  H N N 184 
DC  "HO3'" H N N 185 
DC  "H2'"  H N N 186 
DC  "H2''" H N N 187 
DC  "H1'"  H N N 188 
DC  H41    H N N 189 
DC  H42    H N N 190 
DC  H5     H N N 191 
DC  H6     H N N 192 
DG  OP3    O N N 193 
DG  P      P N N 194 
DG  OP1    O N N 195 
DG  OP2    O N N 196 
DG  "O5'"  O N N 197 
DG  "C5'"  C N N 198 
DG  "C4'"  C N R 199 
DG  "O4'"  O N N 200 
DG  "C3'"  C N S 201 
DG  "O3'"  O N N 202 
DG  "C2'"  C N N 203 
DG  "C1'"  C N R 204 
DG  N9     N Y N 205 
DG  C8     C Y N 206 
DG  N7     N Y N 207 
DG  C5     C Y N 208 
DG  C6     C N N 209 
DG  O6     O N N 210 
DG  N1     N N N 211 
DG  C2     C N N 212 
DG  N2     N N N 213 
DG  N3     N N N 214 
DG  C4     C Y N 215 
DG  HOP3   H N N 216 
DG  HOP2   H N N 217 
DG  "H5'"  H N N 218 
DG  "H5''" H N N 219 
DG  "H4'"  H N N 220 
DG  "H3'"  H N N 221 
DG  "HO3'" H N N 222 
DG  "H2'"  H N N 223 
DG  "H2''" H N N 224 
DG  "H1'"  H N N 225 
DG  H8     H N N 226 
DG  H1     H N N 227 
DG  H21    H N N 228 
DG  H22    H N N 229 
DT  OP3    O N N 230 
DT  P      P N N 231 
DT  OP1    O N N 232 
DT  OP2    O N N 233 
DT  "O5'"  O N N 234 
DT  "C5'"  C N N 235 
DT  "C4'"  C N R 236 
DT  "O4'"  O N N 237 
DT  "C3'"  C N S 238 
DT  "O3'"  O N N 239 
DT  "C2'"  C N N 240 
DT  "C1'"  C N R 241 
DT  N1     N N N 242 
DT  C2     C N N 243 
DT  O2     O N N 244 
DT  N3     N N N 245 
DT  C4     C N N 246 
DT  O4     O N N 247 
DT  C5     C N N 248 
DT  C7     C N N 249 
DT  C6     C N N 250 
DT  HOP3   H N N 251 
DT  HOP2   H N N 252 
DT  "H5'"  H N N 253 
DT  "H5''" H N N 254 
DT  "H4'"  H N N 255 
DT  "H3'"  H N N 256 
DT  "HO3'" H N N 257 
DT  "H2'"  H N N 258 
DT  "H2''" H N N 259 
DT  "H1'"  H N N 260 
DT  H3     H N N 261 
DT  H71    H N N 262 
DT  H72    H N N 263 
DT  H73    H N N 264 
DT  H6     H N N 265 
GLN N      N N N 266 
GLN CA     C N S 267 
GLN C      C N N 268 
GLN O      O N N 269 
GLN CB     C N N 270 
GLN CG     C N N 271 
GLN CD     C N N 272 
GLN OE1    O N N 273 
GLN NE2    N N N 274 
GLN OXT    O N N 275 
GLN H      H N N 276 
GLN H2     H N N 277 
GLN HA     H N N 278 
GLN HB2    H N N 279 
GLN HB3    H N N 280 
GLN HG2    H N N 281 
GLN HG3    H N N 282 
GLN HE21   H N N 283 
GLN HE22   H N N 284 
GLN HXT    H N N 285 
GLU N      N N N 286 
GLU CA     C N S 287 
GLU C      C N N 288 
GLU O      O N N 289 
GLU CB     C N N 290 
GLU CG     C N N 291 
GLU CD     C N N 292 
GLU OE1    O N N 293 
GLU OE2    O N N 294 
GLU OXT    O N N 295 
GLU H      H N N 296 
GLU H2     H N N 297 
GLU HA     H N N 298 
GLU HB2    H N N 299 
GLU HB3    H N N 300 
GLU HG2    H N N 301 
GLU HG3    H N N 302 
GLU HE2    H N N 303 
GLU HXT    H N N 304 
GLY N      N N N 305 
GLY CA     C N N 306 
GLY C      C N N 307 
GLY O      O N N 308 
GLY OXT    O N N 309 
GLY H      H N N 310 
GLY H2     H N N 311 
GLY HA2    H N N 312 
GLY HA3    H N N 313 
GLY HXT    H N N 314 
HIS N      N N N 315 
HIS CA     C N S 316 
HIS C      C N N 317 
HIS O      O N N 318 
HIS CB     C N N 319 
HIS CG     C Y N 320 
HIS ND1    N Y N 321 
HIS CD2    C Y N 322 
HIS CE1    C Y N 323 
HIS NE2    N Y N 324 
HIS OXT    O N N 325 
HIS H      H N N 326 
HIS H2     H N N 327 
HIS HA     H N N 328 
HIS HB2    H N N 329 
HIS HB3    H N N 330 
HIS HD1    H N N 331 
HIS HD2    H N N 332 
HIS HE1    H N N 333 
HIS HE2    H N N 334 
HIS HXT    H N N 335 
ILE N      N N N 336 
ILE CA     C N S 337 
ILE C      C N N 338 
ILE O      O N N 339 
ILE CB     C N S 340 
ILE CG1    C N N 341 
ILE CG2    C N N 342 
ILE CD1    C N N 343 
ILE OXT    O N N 344 
ILE H      H N N 345 
ILE H2     H N N 346 
ILE HA     H N N 347 
ILE HB     H N N 348 
ILE HG12   H N N 349 
ILE HG13   H N N 350 
ILE HG21   H N N 351 
ILE HG22   H N N 352 
ILE HG23   H N N 353 
ILE HD11   H N N 354 
ILE HD12   H N N 355 
ILE HD13   H N N 356 
ILE HXT    H N N 357 
LEU N      N N N 358 
LEU CA     C N S 359 
LEU C      C N N 360 
LEU O      O N N 361 
LEU CB     C N N 362 
LEU CG     C N N 363 
LEU CD1    C N N 364 
LEU CD2    C N N 365 
LEU OXT    O N N 366 
LEU H      H N N 367 
LEU H2     H N N 368 
LEU HA     H N N 369 
LEU HB2    H N N 370 
LEU HB3    H N N 371 
LEU HG     H N N 372 
LEU HD11   H N N 373 
LEU HD12   H N N 374 
LEU HD13   H N N 375 
LEU HD21   H N N 376 
LEU HD22   H N N 377 
LEU HD23   H N N 378 
LEU HXT    H N N 379 
LYS N      N N N 380 
LYS CA     C N S 381 
LYS C      C N N 382 
LYS O      O N N 383 
LYS CB     C N N 384 
LYS CG     C N N 385 
LYS CD     C N N 386 
LYS CE     C N N 387 
LYS NZ     N N N 388 
LYS OXT    O N N 389 
LYS H      H N N 390 
LYS H2     H N N 391 
LYS HA     H N N 392 
LYS HB2    H N N 393 
LYS HB3    H N N 394 
LYS HG2    H N N 395 
LYS HG3    H N N 396 
LYS HD2    H N N 397 
LYS HD3    H N N 398 
LYS HE2    H N N 399 
LYS HE3    H N N 400 
LYS HZ1    H N N 401 
LYS HZ2    H N N 402 
LYS HZ3    H N N 403 
LYS HXT    H N N 404 
MET N      N N N 405 
MET CA     C N S 406 
MET C      C N N 407 
MET O      O N N 408 
MET CB     C N N 409 
MET CG     C N N 410 
MET SD     S N N 411 
MET CE     C N N 412 
MET OXT    O N N 413 
MET H      H N N 414 
MET H2     H N N 415 
MET HA     H N N 416 
MET HB2    H N N 417 
MET HB3    H N N 418 
MET HG2    H N N 419 
MET HG3    H N N 420 
MET HE1    H N N 421 
MET HE2    H N N 422 
MET HE3    H N N 423 
MET HXT    H N N 424 
PHE N      N N N 425 
PHE CA     C N S 426 
PHE C      C N N 427 
PHE O      O N N 428 
PHE CB     C N N 429 
PHE CG     C Y N 430 
PHE CD1    C Y N 431 
PHE CD2    C Y N 432 
PHE CE1    C Y N 433 
PHE CE2    C Y N 434 
PHE CZ     C Y N 435 
PHE OXT    O N N 436 
PHE H      H N N 437 
PHE H2     H N N 438 
PHE HA     H N N 439 
PHE HB2    H N N 440 
PHE HB3    H N N 441 
PHE HD1    H N N 442 
PHE HD2    H N N 443 
PHE HE1    H N N 444 
PHE HE2    H N N 445 
PHE HZ     H N N 446 
PHE HXT    H N N 447 
PRO N      N N N 448 
PRO CA     C N S 449 
PRO C      C N N 450 
PRO O      O N N 451 
PRO CB     C N N 452 
PRO CG     C N N 453 
PRO CD     C N N 454 
PRO OXT    O N N 455 
PRO H      H N N 456 
PRO HA     H N N 457 
PRO HB2    H N N 458 
PRO HB3    H N N 459 
PRO HG2    H N N 460 
PRO HG3    H N N 461 
PRO HD2    H N N 462 
PRO HD3    H N N 463 
PRO HXT    H N N 464 
SER N      N N N 465 
SER CA     C N S 466 
SER C      C N N 467 
SER O      O N N 468 
SER CB     C N N 469 
SER OG     O N N 470 
SER OXT    O N N 471 
SER H      H N N 472 
SER H2     H N N 473 
SER HA     H N N 474 
SER HB2    H N N 475 
SER HB3    H N N 476 
SER HG     H N N 477 
SER HXT    H N N 478 
THR N      N N N 479 
THR CA     C N S 480 
THR C      C N N 481 
THR O      O N N 482 
THR CB     C N R 483 
THR OG1    O N N 484 
THR CG2    C N N 485 
THR OXT    O N N 486 
THR H      H N N 487 
THR H2     H N N 488 
THR HA     H N N 489 
THR HB     H N N 490 
THR HG1    H N N 491 
THR HG21   H N N 492 
THR HG22   H N N 493 
THR HG23   H N N 494 
THR HXT    H N N 495 
TRP N      N N N 496 
TRP CA     C N S 497 
TRP C      C N N 498 
TRP O      O N N 499 
TRP CB     C N N 500 
TRP CG     C Y N 501 
TRP CD1    C Y N 502 
TRP CD2    C Y N 503 
TRP NE1    N Y N 504 
TRP CE2    C Y N 505 
TRP CE3    C Y N 506 
TRP CZ2    C Y N 507 
TRP CZ3    C Y N 508 
TRP CH2    C Y N 509 
TRP OXT    O N N 510 
TRP H      H N N 511 
TRP H2     H N N 512 
TRP HA     H N N 513 
TRP HB2    H N N 514 
TRP HB3    H N N 515 
TRP HD1    H N N 516 
TRP HE1    H N N 517 
TRP HE3    H N N 518 
TRP HZ2    H N N 519 
TRP HZ3    H N N 520 
TRP HH2    H N N 521 
TRP HXT    H N N 522 
TYR N      N N N 523 
TYR CA     C N S 524 
TYR C      C N N 525 
TYR O      O N N 526 
TYR CB     C N N 527 
TYR CG     C Y N 528 
TYR CD1    C Y N 529 
TYR CD2    C Y N 530 
TYR CE1    C Y N 531 
TYR CE2    C Y N 532 
TYR CZ     C Y N 533 
TYR OH     O N N 534 
TYR OXT    O N N 535 
TYR H      H N N 536 
TYR H2     H N N 537 
TYR HA     H N N 538 
TYR HB2    H N N 539 
TYR HB3    H N N 540 
TYR HD1    H N N 541 
TYR HD2    H N N 542 
TYR HE1    H N N 543 
TYR HE2    H N N 544 
TYR HH     H N N 545 
TYR HXT    H N N 546 
VAL N      N N N 547 
VAL CA     C N S 548 
VAL C      C N N 549 
VAL O      O N N 550 
VAL CB     C N N 551 
VAL CG1    C N N 552 
VAL CG2    C N N 553 
VAL OXT    O N N 554 
VAL H      H N N 555 
VAL H2     H N N 556 
VAL HA     H N N 557 
VAL HB     H N N 558 
VAL HG11   H N N 559 
VAL HG12   H N N 560 
VAL HG13   H N N 561 
VAL HG21   H N N 562 
VAL HG22   H N N 563 
VAL HG23   H N N 564 
VAL HXT    H N N 565 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
2DA P     OP1    doub N N 1   
2DA P     OP2    sing N N 2   
2DA P     OP3    sing N N 3   
2DA P     "O5'"  sing N N 4   
2DA OP2   HOP2   sing N N 5   
2DA OP3   HOP3   sing N N 6   
2DA "O5'" "C5'"  sing N N 7   
2DA "C5'" "C4'"  sing N N 8   
2DA "C5'" "H5'"  sing N N 9   
2DA "C5'" "H5''" sing N N 10  
2DA "C4'" "O4'"  sing N N 11  
2DA "C4'" "C3'"  sing N N 12  
2DA "C4'" "H4'"  sing N N 13  
2DA "O4'" "C1'"  sing N N 14  
2DA "C3'" "C2'"  sing N N 15  
2DA "C3'" "H3'1" sing N N 16  
2DA "C3'" "H3'2" sing N N 17  
2DA "C2'" "C1'"  sing N N 18  
2DA "C2'" "H2'"  sing N N 19  
2DA "C2'" "H2''" sing N N 20  
2DA "C1'" N9     sing N N 21  
2DA "C1'" "H1'"  sing N N 22  
2DA N9    C8     sing Y N 23  
2DA N9    C4     sing Y N 24  
2DA C8    N7     doub Y N 25  
2DA C8    H8     sing N N 26  
2DA N7    C5     sing Y N 27  
2DA C5    C6     sing Y N 28  
2DA C5    C4     doub Y N 29  
2DA C6    N6     sing N N 30  
2DA C6    N1     doub Y N 31  
2DA N6    HN61   sing N N 32  
2DA N6    HN62   sing N N 33  
2DA N1    C2     sing Y N 34  
2DA C2    N3     doub Y N 35  
2DA C2    H2     sing N N 36  
2DA N3    C4     sing Y N 37  
ALA N     CA     sing N N 38  
ALA N     H      sing N N 39  
ALA N     H2     sing N N 40  
ALA CA    C      sing N N 41  
ALA CA    CB     sing N N 42  
ALA CA    HA     sing N N 43  
ALA C     O      doub N N 44  
ALA C     OXT    sing N N 45  
ALA CB    HB1    sing N N 46  
ALA CB    HB2    sing N N 47  
ALA CB    HB3    sing N N 48  
ALA OXT   HXT    sing N N 49  
ARG N     CA     sing N N 50  
ARG N     H      sing N N 51  
ARG N     H2     sing N N 52  
ARG CA    C      sing N N 53  
ARG CA    CB     sing N N 54  
ARG CA    HA     sing N N 55  
ARG C     O      doub N N 56  
ARG C     OXT    sing N N 57  
ARG CB    CG     sing N N 58  
ARG CB    HB2    sing N N 59  
ARG CB    HB3    sing N N 60  
ARG CG    CD     sing N N 61  
ARG CG    HG2    sing N N 62  
ARG CG    HG3    sing N N 63  
ARG CD    NE     sing N N 64  
ARG CD    HD2    sing N N 65  
ARG CD    HD3    sing N N 66  
ARG NE    CZ     sing N N 67  
ARG NE    HE     sing N N 68  
ARG CZ    NH1    sing N N 69  
ARG CZ    NH2    doub N N 70  
ARG NH1   HH11   sing N N 71  
ARG NH1   HH12   sing N N 72  
ARG NH2   HH21   sing N N 73  
ARG NH2   HH22   sing N N 74  
ARG OXT   HXT    sing N N 75  
ASN N     CA     sing N N 76  
ASN N     H      sing N N 77  
ASN N     H2     sing N N 78  
ASN CA    C      sing N N 79  
ASN CA    CB     sing N N 80  
ASN CA    HA     sing N N 81  
ASN C     O      doub N N 82  
ASN C     OXT    sing N N 83  
ASN CB    CG     sing N N 84  
ASN CB    HB2    sing N N 85  
ASN CB    HB3    sing N N 86  
ASN CG    OD1    doub N N 87  
ASN CG    ND2    sing N N 88  
ASN ND2   HD21   sing N N 89  
ASN ND2   HD22   sing N N 90  
ASN OXT   HXT    sing N N 91  
ASP N     CA     sing N N 92  
ASP N     H      sing N N 93  
ASP N     H2     sing N N 94  
ASP CA    C      sing N N 95  
ASP CA    CB     sing N N 96  
ASP CA    HA     sing N N 97  
ASP C     O      doub N N 98  
ASP C     OXT    sing N N 99  
ASP CB    CG     sing N N 100 
ASP CB    HB2    sing N N 101 
ASP CB    HB3    sing N N 102 
ASP CG    OD1    doub N N 103 
ASP CG    OD2    sing N N 104 
ASP OD2   HD2    sing N N 105 
ASP OXT   HXT    sing N N 106 
CYS N     CA     sing N N 107 
CYS N     H      sing N N 108 
CYS N     H2     sing N N 109 
CYS CA    C      sing N N 110 
CYS CA    CB     sing N N 111 
CYS CA    HA     sing N N 112 
CYS C     O      doub N N 113 
CYS C     OXT    sing N N 114 
CYS CB    SG     sing N N 115 
CYS CB    HB2    sing N N 116 
CYS CB    HB3    sing N N 117 
CYS SG    HG     sing N N 118 
CYS OXT   HXT    sing N N 119 
DA  OP3   P      sing N N 120 
DA  OP3   HOP3   sing N N 121 
DA  P     OP1    doub N N 122 
DA  P     OP2    sing N N 123 
DA  P     "O5'"  sing N N 124 
DA  OP2   HOP2   sing N N 125 
DA  "O5'" "C5'"  sing N N 126 
DA  "C5'" "C4'"  sing N N 127 
DA  "C5'" "H5'"  sing N N 128 
DA  "C5'" "H5''" sing N N 129 
DA  "C4'" "O4'"  sing N N 130 
DA  "C4'" "C3'"  sing N N 131 
DA  "C4'" "H4'"  sing N N 132 
DA  "O4'" "C1'"  sing N N 133 
DA  "C3'" "O3'"  sing N N 134 
DA  "C3'" "C2'"  sing N N 135 
DA  "C3'" "H3'"  sing N N 136 
DA  "O3'" "HO3'" sing N N 137 
DA  "C2'" "C1'"  sing N N 138 
DA  "C2'" "H2'"  sing N N 139 
DA  "C2'" "H2''" sing N N 140 
DA  "C1'" N9     sing N N 141 
DA  "C1'" "H1'"  sing N N 142 
DA  N9    C8     sing Y N 143 
DA  N9    C4     sing Y N 144 
DA  C8    N7     doub Y N 145 
DA  C8    H8     sing N N 146 
DA  N7    C5     sing Y N 147 
DA  C5    C6     sing Y N 148 
DA  C5    C4     doub Y N 149 
DA  C6    N6     sing N N 150 
DA  C6    N1     doub Y N 151 
DA  N6    H61    sing N N 152 
DA  N6    H62    sing N N 153 
DA  N1    C2     sing Y N 154 
DA  C2    N3     doub Y N 155 
DA  C2    H2     sing N N 156 
DA  N3    C4     sing Y N 157 
DC  OP3   P      sing N N 158 
DC  OP3   HOP3   sing N N 159 
DC  P     OP1    doub N N 160 
DC  P     OP2    sing N N 161 
DC  P     "O5'"  sing N N 162 
DC  OP2   HOP2   sing N N 163 
DC  "O5'" "C5'"  sing N N 164 
DC  "C5'" "C4'"  sing N N 165 
DC  "C5'" "H5'"  sing N N 166 
DC  "C5'" "H5''" sing N N 167 
DC  "C4'" "O4'"  sing N N 168 
DC  "C4'" "C3'"  sing N N 169 
DC  "C4'" "H4'"  sing N N 170 
DC  "O4'" "C1'"  sing N N 171 
DC  "C3'" "O3'"  sing N N 172 
DC  "C3'" "C2'"  sing N N 173 
DC  "C3'" "H3'"  sing N N 174 
DC  "O3'" "HO3'" sing N N 175 
DC  "C2'" "C1'"  sing N N 176 
DC  "C2'" "H2'"  sing N N 177 
DC  "C2'" "H2''" sing N N 178 
DC  "C1'" N1     sing N N 179 
DC  "C1'" "H1'"  sing N N 180 
DC  N1    C2     sing N N 181 
DC  N1    C6     sing N N 182 
DC  C2    O2     doub N N 183 
DC  C2    N3     sing N N 184 
DC  N3    C4     doub N N 185 
DC  C4    N4     sing N N 186 
DC  C4    C5     sing N N 187 
DC  N4    H41    sing N N 188 
DC  N4    H42    sing N N 189 
DC  C5    C6     doub N N 190 
DC  C5    H5     sing N N 191 
DC  C6    H6     sing N N 192 
DG  OP3   P      sing N N 193 
DG  OP3   HOP3   sing N N 194 
DG  P     OP1    doub N N 195 
DG  P     OP2    sing N N 196 
DG  P     "O5'"  sing N N 197 
DG  OP2   HOP2   sing N N 198 
DG  "O5'" "C5'"  sing N N 199 
DG  "C5'" "C4'"  sing N N 200 
DG  "C5'" "H5'"  sing N N 201 
DG  "C5'" "H5''" sing N N 202 
DG  "C4'" "O4'"  sing N N 203 
DG  "C4'" "C3'"  sing N N 204 
DG  "C4'" "H4'"  sing N N 205 
DG  "O4'" "C1'"  sing N N 206 
DG  "C3'" "O3'"  sing N N 207 
DG  "C3'" "C2'"  sing N N 208 
DG  "C3'" "H3'"  sing N N 209 
DG  "O3'" "HO3'" sing N N 210 
DG  "C2'" "C1'"  sing N N 211 
DG  "C2'" "H2'"  sing N N 212 
DG  "C2'" "H2''" sing N N 213 
DG  "C1'" N9     sing N N 214 
DG  "C1'" "H1'"  sing N N 215 
DG  N9    C8     sing Y N 216 
DG  N9    C4     sing Y N 217 
DG  C8    N7     doub Y N 218 
DG  C8    H8     sing N N 219 
DG  N7    C5     sing Y N 220 
DG  C5    C6     sing N N 221 
DG  C5    C4     doub Y N 222 
DG  C6    O6     doub N N 223 
DG  C6    N1     sing N N 224 
DG  N1    C2     sing N N 225 
DG  N1    H1     sing N N 226 
DG  C2    N2     sing N N 227 
DG  C2    N3     doub N N 228 
DG  N2    H21    sing N N 229 
DG  N2    H22    sing N N 230 
DG  N3    C4     sing N N 231 
DT  OP3   P      sing N N 232 
DT  OP3   HOP3   sing N N 233 
DT  P     OP1    doub N N 234 
DT  P     OP2    sing N N 235 
DT  P     "O5'"  sing N N 236 
DT  OP2   HOP2   sing N N 237 
DT  "O5'" "C5'"  sing N N 238 
DT  "C5'" "C4'"  sing N N 239 
DT  "C5'" "H5'"  sing N N 240 
DT  "C5'" "H5''" sing N N 241 
DT  "C4'" "O4'"  sing N N 242 
DT  "C4'" "C3'"  sing N N 243 
DT  "C4'" "H4'"  sing N N 244 
DT  "O4'" "C1'"  sing N N 245 
DT  "C3'" "O3'"  sing N N 246 
DT  "C3'" "C2'"  sing N N 247 
DT  "C3'" "H3'"  sing N N 248 
DT  "O3'" "HO3'" sing N N 249 
DT  "C2'" "C1'"  sing N N 250 
DT  "C2'" "H2'"  sing N N 251 
DT  "C2'" "H2''" sing N N 252 
DT  "C1'" N1     sing N N 253 
DT  "C1'" "H1'"  sing N N 254 
DT  N1    C2     sing N N 255 
DT  N1    C6     sing N N 256 
DT  C2    O2     doub N N 257 
DT  C2    N3     sing N N 258 
DT  N3    C4     sing N N 259 
DT  N3    H3     sing N N 260 
DT  C4    O4     doub N N 261 
DT  C4    C5     sing N N 262 
DT  C5    C7     sing N N 263 
DT  C5    C6     doub N N 264 
DT  C7    H71    sing N N 265 
DT  C7    H72    sing N N 266 
DT  C7    H73    sing N N 267 
DT  C6    H6     sing N N 268 
GLN N     CA     sing N N 269 
GLN N     H      sing N N 270 
GLN N     H2     sing N N 271 
GLN CA    C      sing N N 272 
GLN CA    CB     sing N N 273 
GLN CA    HA     sing N N 274 
GLN C     O      doub N N 275 
GLN C     OXT    sing N N 276 
GLN CB    CG     sing N N 277 
GLN CB    HB2    sing N N 278 
GLN CB    HB3    sing N N 279 
GLN CG    CD     sing N N 280 
GLN CG    HG2    sing N N 281 
GLN CG    HG3    sing N N 282 
GLN CD    OE1    doub N N 283 
GLN CD    NE2    sing N N 284 
GLN NE2   HE21   sing N N 285 
GLN NE2   HE22   sing N N 286 
GLN OXT   HXT    sing N N 287 
GLU N     CA     sing N N 288 
GLU N     H      sing N N 289 
GLU N     H2     sing N N 290 
GLU CA    C      sing N N 291 
GLU CA    CB     sing N N 292 
GLU CA    HA     sing N N 293 
GLU C     O      doub N N 294 
GLU C     OXT    sing N N 295 
GLU CB    CG     sing N N 296 
GLU CB    HB2    sing N N 297 
GLU CB    HB3    sing N N 298 
GLU CG    CD     sing N N 299 
GLU CG    HG2    sing N N 300 
GLU CG    HG3    sing N N 301 
GLU CD    OE1    doub N N 302 
GLU CD    OE2    sing N N 303 
GLU OE2   HE2    sing N N 304 
GLU OXT   HXT    sing N N 305 
GLY N     CA     sing N N 306 
GLY N     H      sing N N 307 
GLY N     H2     sing N N 308 
GLY CA    C      sing N N 309 
GLY CA    HA2    sing N N 310 
GLY CA    HA3    sing N N 311 
GLY C     O      doub N N 312 
GLY C     OXT    sing N N 313 
GLY OXT   HXT    sing N N 314 
HIS N     CA     sing N N 315 
HIS N     H      sing N N 316 
HIS N     H2     sing N N 317 
HIS CA    C      sing N N 318 
HIS CA    CB     sing N N 319 
HIS CA    HA     sing N N 320 
HIS C     O      doub N N 321 
HIS C     OXT    sing N N 322 
HIS CB    CG     sing N N 323 
HIS CB    HB2    sing N N 324 
HIS CB    HB3    sing N N 325 
HIS CG    ND1    sing Y N 326 
HIS CG    CD2    doub Y N 327 
HIS ND1   CE1    doub Y N 328 
HIS ND1   HD1    sing N N 329 
HIS CD2   NE2    sing Y N 330 
HIS CD2   HD2    sing N N 331 
HIS CE1   NE2    sing Y N 332 
HIS CE1   HE1    sing N N 333 
HIS NE2   HE2    sing N N 334 
HIS OXT   HXT    sing N N 335 
ILE N     CA     sing N N 336 
ILE N     H      sing N N 337 
ILE N     H2     sing N N 338 
ILE CA    C      sing N N 339 
ILE CA    CB     sing N N 340 
ILE CA    HA     sing N N 341 
ILE C     O      doub N N 342 
ILE C     OXT    sing N N 343 
ILE CB    CG1    sing N N 344 
ILE CB    CG2    sing N N 345 
ILE CB    HB     sing N N 346 
ILE CG1   CD1    sing N N 347 
ILE CG1   HG12   sing N N 348 
ILE CG1   HG13   sing N N 349 
ILE CG2   HG21   sing N N 350 
ILE CG2   HG22   sing N N 351 
ILE CG2   HG23   sing N N 352 
ILE CD1   HD11   sing N N 353 
ILE CD1   HD12   sing N N 354 
ILE CD1   HD13   sing N N 355 
ILE OXT   HXT    sing N N 356 
LEU N     CA     sing N N 357 
LEU N     H      sing N N 358 
LEU N     H2     sing N N 359 
LEU CA    C      sing N N 360 
LEU CA    CB     sing N N 361 
LEU CA    HA     sing N N 362 
LEU C     O      doub N N 363 
LEU C     OXT    sing N N 364 
LEU CB    CG     sing N N 365 
LEU CB    HB2    sing N N 366 
LEU CB    HB3    sing N N 367 
LEU CG    CD1    sing N N 368 
LEU CG    CD2    sing N N 369 
LEU CG    HG     sing N N 370 
LEU CD1   HD11   sing N N 371 
LEU CD1   HD12   sing N N 372 
LEU CD1   HD13   sing N N 373 
LEU CD2   HD21   sing N N 374 
LEU CD2   HD22   sing N N 375 
LEU CD2   HD23   sing N N 376 
LEU OXT   HXT    sing N N 377 
LYS N     CA     sing N N 378 
LYS N     H      sing N N 379 
LYS N     H2     sing N N 380 
LYS CA    C      sing N N 381 
LYS CA    CB     sing N N 382 
LYS CA    HA     sing N N 383 
LYS C     O      doub N N 384 
LYS C     OXT    sing N N 385 
LYS CB    CG     sing N N 386 
LYS CB    HB2    sing N N 387 
LYS CB    HB3    sing N N 388 
LYS CG    CD     sing N N 389 
LYS CG    HG2    sing N N 390 
LYS CG    HG3    sing N N 391 
LYS CD    CE     sing N N 392 
LYS CD    HD2    sing N N 393 
LYS CD    HD3    sing N N 394 
LYS CE    NZ     sing N N 395 
LYS CE    HE2    sing N N 396 
LYS CE    HE3    sing N N 397 
LYS NZ    HZ1    sing N N 398 
LYS NZ    HZ2    sing N N 399 
LYS NZ    HZ3    sing N N 400 
LYS OXT   HXT    sing N N 401 
MET N     CA     sing N N 402 
MET N     H      sing N N 403 
MET N     H2     sing N N 404 
MET CA    C      sing N N 405 
MET CA    CB     sing N N 406 
MET CA    HA     sing N N 407 
MET C     O      doub N N 408 
MET C     OXT    sing N N 409 
MET CB    CG     sing N N 410 
MET CB    HB2    sing N N 411 
MET CB    HB3    sing N N 412 
MET CG    SD     sing N N 413 
MET CG    HG2    sing N N 414 
MET CG    HG3    sing N N 415 
MET SD    CE     sing N N 416 
MET CE    HE1    sing N N 417 
MET CE    HE2    sing N N 418 
MET CE    HE3    sing N N 419 
MET OXT   HXT    sing N N 420 
PHE N     CA     sing N N 421 
PHE N     H      sing N N 422 
PHE N     H2     sing N N 423 
PHE CA    C      sing N N 424 
PHE CA    CB     sing N N 425 
PHE CA    HA     sing N N 426 
PHE C     O      doub N N 427 
PHE C     OXT    sing N N 428 
PHE CB    CG     sing N N 429 
PHE CB    HB2    sing N N 430 
PHE CB    HB3    sing N N 431 
PHE CG    CD1    doub Y N 432 
PHE CG    CD2    sing Y N 433 
PHE CD1   CE1    sing Y N 434 
PHE CD1   HD1    sing N N 435 
PHE CD2   CE2    doub Y N 436 
PHE CD2   HD2    sing N N 437 
PHE CE1   CZ     doub Y N 438 
PHE CE1   HE1    sing N N 439 
PHE CE2   CZ     sing Y N 440 
PHE CE2   HE2    sing N N 441 
PHE CZ    HZ     sing N N 442 
PHE OXT   HXT    sing N N 443 
PRO N     CA     sing N N 444 
PRO N     CD     sing N N 445 
PRO N     H      sing N N 446 
PRO CA    C      sing N N 447 
PRO CA    CB     sing N N 448 
PRO CA    HA     sing N N 449 
PRO C     O      doub N N 450 
PRO C     OXT    sing N N 451 
PRO CB    CG     sing N N 452 
PRO CB    HB2    sing N N 453 
PRO CB    HB3    sing N N 454 
PRO CG    CD     sing N N 455 
PRO CG    HG2    sing N N 456 
PRO CG    HG3    sing N N 457 
PRO CD    HD2    sing N N 458 
PRO CD    HD3    sing N N 459 
PRO OXT   HXT    sing N N 460 
SER N     CA     sing N N 461 
SER N     H      sing N N 462 
SER N     H2     sing N N 463 
SER CA    C      sing N N 464 
SER CA    CB     sing N N 465 
SER CA    HA     sing N N 466 
SER C     O      doub N N 467 
SER C     OXT    sing N N 468 
SER CB    OG     sing N N 469 
SER CB    HB2    sing N N 470 
SER CB    HB3    sing N N 471 
SER OG    HG     sing N N 472 
SER OXT   HXT    sing N N 473 
THR N     CA     sing N N 474 
THR N     H      sing N N 475 
THR N     H2     sing N N 476 
THR CA    C      sing N N 477 
THR CA    CB     sing N N 478 
THR CA    HA     sing N N 479 
THR C     O      doub N N 480 
THR C     OXT    sing N N 481 
THR CB    OG1    sing N N 482 
THR CB    CG2    sing N N 483 
THR CB    HB     sing N N 484 
THR OG1   HG1    sing N N 485 
THR CG2   HG21   sing N N 486 
THR CG2   HG22   sing N N 487 
THR CG2   HG23   sing N N 488 
THR OXT   HXT    sing N N 489 
TRP N     CA     sing N N 490 
TRP N     H      sing N N 491 
TRP N     H2     sing N N 492 
TRP CA    C      sing N N 493 
TRP CA    CB     sing N N 494 
TRP CA    HA     sing N N 495 
TRP C     O      doub N N 496 
TRP C     OXT    sing N N 497 
TRP CB    CG     sing N N 498 
TRP CB    HB2    sing N N 499 
TRP CB    HB3    sing N N 500 
TRP CG    CD1    doub Y N 501 
TRP CG    CD2    sing Y N 502 
TRP CD1   NE1    sing Y N 503 
TRP CD1   HD1    sing N N 504 
TRP CD2   CE2    doub Y N 505 
TRP CD2   CE3    sing Y N 506 
TRP NE1   CE2    sing Y N 507 
TRP NE1   HE1    sing N N 508 
TRP CE2   CZ2    sing Y N 509 
TRP CE3   CZ3    doub Y N 510 
TRP CE3   HE3    sing N N 511 
TRP CZ2   CH2    doub Y N 512 
TRP CZ2   HZ2    sing N N 513 
TRP CZ3   CH2    sing Y N 514 
TRP CZ3   HZ3    sing N N 515 
TRP CH2   HH2    sing N N 516 
TRP OXT   HXT    sing N N 517 
TYR N     CA     sing N N 518 
TYR N     H      sing N N 519 
TYR N     H2     sing N N 520 
TYR CA    C      sing N N 521 
TYR CA    CB     sing N N 522 
TYR CA    HA     sing N N 523 
TYR C     O      doub N N 524 
TYR C     OXT    sing N N 525 
TYR CB    CG     sing N N 526 
TYR CB    HB2    sing N N 527 
TYR CB    HB3    sing N N 528 
TYR CG    CD1    doub Y N 529 
TYR CG    CD2    sing Y N 530 
TYR CD1   CE1    sing Y N 531 
TYR CD1   HD1    sing N N 532 
TYR CD2   CE2    doub Y N 533 
TYR CD2   HD2    sing N N 534 
TYR CE1   CZ     doub Y N 535 
TYR CE1   HE1    sing N N 536 
TYR CE2   CZ     sing Y N 537 
TYR CE2   HE2    sing N N 538 
TYR CZ    OH     sing N N 539 
TYR OH    HH     sing N N 540 
TYR OXT   HXT    sing N N 541 
VAL N     CA     sing N N 542 
VAL N     H      sing N N 543 
VAL N     H2     sing N N 544 
VAL CA    C      sing N N 545 
VAL CA    CB     sing N N 546 
VAL CA    HA     sing N N 547 
VAL C     O      doub N N 548 
VAL C     OXT    sing N N 549 
VAL CB    CG1    sing N N 550 
VAL CB    CG2    sing N N 551 
VAL CB    HB     sing N N 552 
VAL CG1   HG11   sing N N 553 
VAL CG1   HG12   sing N N 554 
VAL CG1   HG13   sing N N 555 
VAL CG2   HG21   sing N N 556 
VAL CG2   HG22   sing N N 557 
VAL CG2   HG23   sing N N 558 
VAL OXT   HXT    sing N N 559 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-09-01 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9DG1 
_em_admin.last_update        2024-11-27 
_em_admin.map_release_date   2024-11-06 
_em_admin.title              'Structure of Plasmodium falciparum apicoplast DNA polymerase in complex with DNA (exo-minus)' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          5833 
_em_entity_assembly_naturalsource.organism             'Plasmodium falciparum' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          866768 
_em_entity_assembly_recombinant.organism             
;Escherichia coli 'BL21-Gold(DE3)pLysS AG'
;
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               7 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         49 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
9DG1 'double helix'        
9DG1 'b-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 B DT 10 1_555 C 2DA 20 1_555 1.287  0.011  0.551  -7.574  -18.925 -46.419 1  E_DT10:2DA20_F E 10 ? F 20 ? ?  ? 
1 B DC 11 1_555 C DG  19 1_555 0.604  -0.605 0.588  -6.814  -22.634 -13.336 2  E_DC11:DG19_F  E 11 ? F 19 ? 19 1 
1 B DT 12 1_555 C DA  18 1_555 0.476  -0.430 0.483  -9.885  -20.583 -17.111 3  E_DT12:DA18_F  E 12 ? F 18 ? 20 1 
1 B DA 13 1_555 C DT  17 1_555 -0.811 -0.216 -1.213 -13.965 7.317   -37.967 4  E_DA13:DT17_F  E 13 ? F 17 ? 20 1 
1 B DC 14 1_555 C DG  16 1_555 -0.790 -0.594 -0.958 5.914   21.488  -18.855 5  E_DC14:DG16_F  E 14 ? F 16 ? 19 1 
1 B DG 16 1_555 C DC  15 1_555 -0.810 -0.616 1.661  2.197   -16.743 2.407   6  E_DG16:DC15_F  E 16 ? F 15 ? 19 1 
1 B DA 17 1_555 C DT  13 1_555 -0.820 0.403  -1.329 -8.822  -4.144  -38.730 7  E_DA17:DT13_F  E 17 ? F 13 ? ?  ? 
1 B DT 18 1_555 C DA  12 1_555 -1.039 0.392  -0.717 -6.488  6.413   -43.575 8  E_DT18:DA12_F  E 18 ? F 12 ? ?  ? 
1 B DG 19 1_555 C DC  11 1_555 0.259  0.479  -1.153 -10.485 1.027   -42.643 9  E_DG19:DC11_F  E 19 ? F 11 ? ?  ? 
1 B DC 21 1_555 C DG  10 1_555 1.314  -1.053 1.284  10.374  -15.201 -1.893  10 E_DC21:DG10_F  E 21 ? F 10 ? 19 1 
1 B DT 22 1_555 C DG  9  1_555 1.715  -0.308 0.066  25.044  -20.847 12.347  11 E_DT22:DG9_F   E 22 ? F 9  ? 28 1 
1 B DC 23 1_555 C DA  8  1_555 1.023  -0.408 1.393  13.353  -15.714 12.696  12 E_DC23:DA8_F   E 23 ? F 8  ? ?  1 
1 B DC 25 1_555 C DT  6  1_555 -0.386 -1.168 0.969  -5.057  2.507   12.568  13 E_DC25:DT6_F   E 25 ? F 6  ? 18 1 
1 B DA 26 1_555 C DT  4  1_555 -1.331 0.054  -1.375 -0.828  -1.159  -24.655 14 E_DA26:DT4_F   E 26 ? F 4  ? ?  ? 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 B DT 10 1_555 C 2DA 20 1_555 B DC 11 1_555 C DG 19 1_555 0.684  -1.609 2.725 2.672  -0.320 30.122 -3.030 -0.853 2.791 -0.613  
-5.128  30.239 1  EE_DT10DC11:DG192DA20_FF E 10 ? F 20 ? E 11 ? F 19 ? 
1 B DC 11 1_555 C DG  19 1_555 B DT 12 1_555 C DA 18 1_555 -0.586 -0.910 3.043 3.310  3.051  34.314 -1.958 1.450  2.887 5.144   
-5.580  34.599 2  EE_DC11DT12:DA18DG19_FF  E 11 ? F 19 ? E 12 ? F 18 ? 
1 B DT 12 1_555 C DA  18 1_555 B DA 13 1_555 C DT 17 1_555 -0.913 -0.419 3.279 14.367 9.576  28.788 -2.191 3.781  2.330 17.422  
-26.140 33.475 3  EE_DT12DA13:DT17DA18_FF  E 12 ? F 18 ? E 13 ? F 17 ? 
1 B DA 13 1_555 C DT  17 1_555 B DC 14 1_555 C DG 16 1_555 0.645  -0.569 2.995 -2.972 1.503  29.926 -1.373 -1.790 2.888 2.900   
5.734   30.106 4  EE_DA13DC14:DG16DT17_FF  E 13 ? F 17 ? E 14 ? F 16 ? 
1 B DC 14 1_555 C DG  16 1_555 B DG 16 1_555 C DC 15 1_555 0.152  0.467  4.956 7.769  6.240  55.385 -0.046 0.513  4.956 6.654   
-8.284  56.204 5  EE_DC14DG16:DC15DG16_FF  E 14 ? F 16 ? E 16 ? F 15 ? 
1 B DG 16 1_555 C DC  15 1_555 B DA 17 1_555 C DT 13 1_555 0.402  -0.851 4.816 -0.760 -1.316 55.792 -0.798 -0.494 4.828 -1.406  
0.812   55.811 6  EE_DG16DA17:DT13DC15_FF  E 16 ? F 15 ? E 17 ? F 13 ? 
1 B DA 17 1_555 C DT  13 1_555 B DT 18 1_555 C DA 12 1_555 -0.513 -1.106 3.260 -1.643 -3.635 27.535 -1.409 0.663  3.400 -7.586  
3.430   27.817 7  EE_DA17DT18:DA12DT13_FF  E 17 ? F 13 ? E 18 ? F 12 ? 
1 B DT 18 1_555 C DA  12 1_555 B DG 19 1_555 C DC 11 1_555 0.588  -1.209 3.512 3.270  9.271  40.742 -2.702 -0.467 3.209 13.087  
-4.616  41.863 8  EE_DT18DG19:DC11DA12_FF  E 18 ? F 12 ? E 19 ? F 11 ? 
1 B DG 19 1_555 C DC  11 1_555 B DC 21 1_555 C DG 10 1_555 -0.337 -0.351 4.112 4.049  -9.070 48.745 0.425  0.777  4.073 -10.859 
-4.848  49.687 9  EE_DG19DC21:DG10DC11_FF  E 19 ? F 11 ? E 21 ? F 10 ? 
1 B DC 21 1_555 C DG  10 1_555 B DT 22 1_555 C DG 9  1_555 0.803  0.356  2.742 16.622 3.565  34.330 0.138  0.667  2.845 5.632   
-26.261 38.195 10 EE_DC21DT22:DG9DG10_FF   E 21 ? F 10 ? E 22 ? F 9  ? 
1 B DT 22 1_555 C DG  9  1_555 B DC 23 1_555 C DA 8  1_555 -0.280 0.573  3.640 -4.621 10.089 33.799 -0.751 -0.315 3.662 16.800  
7.695   35.523 11 EE_DT22DC23:DA8DG9_FF    E 22 ? F 9  ? E 23 ? F 8  ? 
1 B DC 23 1_555 C DA  8  1_555 B DC 25 1_555 C DT 6  1_555 0.255  1.771  7.152 6.889  7.132  70.277 0.980  0.309  7.275 6.164   
-5.955  70.884 12 EE_DC23DC25:DT6DA8_FF    E 23 ? F 8  ? E 25 ? F 6  ? 
1 B DC 25 1_555 C DT  6  1_555 B DA 26 1_555 C DT 4  1_555 0.284  1.686  4.788 -1.400 -0.743 50.705 2.045  -0.475 4.756 -0.868  
1.635   50.729 13 EE_DC25DA26:DT4DT6_FF    E 25 ? F 6  ? E 26 ? F 4  ? 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           1R35GM142722 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9DG1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
P 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . ASP A 1 50  ? 79.448  116.779 139.061 1.00 1033.9 ? 50  ASP A N     1 
ATOM   2    C CA    . ASP A 1 50  ? 78.483  115.735 138.744 1.00 1033.9 ? 50  ASP A CA    1 
ATOM   3    C C     . ASP A 1 50  ? 79.203  114.438 138.380 1.00 1033.9 ? 50  ASP A C     1 
ATOM   4    O O     . ASP A 1 50  ? 78.836  113.756 137.425 1.00 1033.9 ? 50  ASP A O     1 
ATOM   5    C CB    . ASP A 1 50  ? 77.566  116.179 137.602 1.00 1033.9 ? 50  ASP A CB    1 
ATOM   6    C CG    . ASP A 1 50  ? 76.318  115.324 137.485 1.00 1033.9 ? 50  ASP A CG    1 
ATOM   7    O OD1   . ASP A 1 50  ? 76.111  114.446 138.349 1.00 1033.9 ? 50  ASP A OD1   1 
ATOM   8    O OD2   . ASP A 1 50  ? 75.544  115.529 136.526 1.00 1033.9 ? 50  ASP A OD2   1 
ATOM   9    N N     . ASP A 1 51  ? 80.237  114.109 139.149 1.00 989.49 ? 51  ASP A N     1 
ATOM   10   C CA    . ASP A 1 51  ? 81.029  112.909 138.911 1.00 989.49 ? 51  ASP A CA    1 
ATOM   11   C C     . ASP A 1 51  ? 81.767  112.559 140.197 1.00 989.49 ? 51  ASP A C     1 
ATOM   12   O O     . ASP A 1 51  ? 81.574  113.190 141.241 1.00 989.49 ? 51  ASP A O     1 
ATOM   13   C CB    . ASP A 1 51  ? 81.994  113.107 137.736 1.00 989.49 ? 51  ASP A CB    1 
ATOM   14   C CG    . ASP A 1 51  ? 82.936  114.281 137.940 1.00 989.49 ? 51  ASP A CG    1 
ATOM   15   O OD1   . ASP A 1 51  ? 83.806  114.208 138.833 1.00 989.49 ? 51  ASP A OD1   1 
ATOM   16   O OD2   . ASP A 1 51  ? 82.807  115.280 137.202 1.00 989.49 ? 51  ASP A OD2   1 
ATOM   17   N N     . ASP A 1 52  ? 82.623  111.540 140.112 1.00 924.16 ? 52  ASP A N     1 
ATOM   18   C CA    . ASP A 1 52  ? 83.369  111.042 141.259 1.00 924.16 ? 52  ASP A CA    1 
ATOM   19   C C     . ASP A 1 52  ? 84.870  111.239 141.091 1.00 924.16 ? 52  ASP A C     1 
ATOM   20   O O     . ASP A 1 52  ? 85.663  110.558 141.752 1.00 924.16 ? 52  ASP A O     1 
ATOM   21   C CB    . ASP A 1 52  ? 83.051  109.566 141.503 1.00 924.16 ? 52  ASP A CB    1 
ATOM   22   C CG    . ASP A 1 52  ? 83.380  108.692 140.307 1.00 924.16 ? 52  ASP A CG    1 
ATOM   23   O OD1   . ASP A 1 52  ? 83.652  109.240 139.218 1.00 924.16 ? 52  ASP A OD1   1 
ATOM   24   O OD2   . ASP A 1 52  ? 83.370  107.451 140.457 1.00 924.16 ? 52  ASP A OD2   1 
ATOM   25   N N     . ILE A 1 53  ? 85.277  112.159 140.218 1.00 776.49 ? 53  ILE A N     1 
ATOM   26   C CA    . ILE A 1 53  ? 86.689  112.473 140.061 1.00 776.49 ? 53  ILE A CA    1 
ATOM   27   C C     . ILE A 1 53  ? 87.121  113.398 141.189 1.00 776.49 ? 53  ILE A C     1 
ATOM   28   O O     . ILE A 1 53  ? 86.443  114.388 141.498 1.00 776.49 ? 53  ILE A O     1 
ATOM   29   C CB    . ILE A 1 53  ? 86.939  113.102 138.683 1.00 776.49 ? 53  ILE A CB    1 
ATOM   30   C CG1   . ILE A 1 53  ? 86.617  112.100 137.571 1.00 776.49 ? 53  ILE A CG1   1 
ATOM   31   C CG2   . ILE A 1 53  ? 88.366  113.578 138.554 1.00 776.49 ? 53  ILE A CG2   1 
ATOM   32   C CD1   . ILE A 1 53  ? 86.710  112.683 136.178 1.00 776.49 ? 53  ILE A CD1   1 
ATOM   33   N N     . GLU A 1 54  ? 88.248  113.072 141.821 1.00 663.76 ? 54  GLU A N     1 
ATOM   34   C CA    . GLU A 1 54  ? 88.763  113.887 142.914 1.00 663.76 ? 54  GLU A CA    1 
ATOM   35   C C     . GLU A 1 54  ? 89.051  115.303 142.431 1.00 663.76 ? 54  GLU A C     1 
ATOM   36   O O     . GLU A 1 54  ? 89.864  115.512 141.527 1.00 663.76 ? 54  GLU A O     1 
ATOM   37   C CB    . GLU A 1 54  ? 90.028  113.252 143.493 1.00 663.76 ? 54  GLU A CB    1 
ATOM   38   C CG    . GLU A 1 54  ? 90.626  114.005 144.669 1.00 663.76 ? 54  GLU A CG    1 
ATOM   39   C CD    . GLU A 1 54  ? 89.603  114.301 145.747 1.00 663.76 ? 54  GLU A CD    1 
ATOM   40   O OE1   . GLU A 1 54  ? 89.030  113.340 146.303 1.00 663.76 ? 54  GLU A OE1   1 
ATOM   41   O OE2   . GLU A 1 54  ? 89.370  115.492 146.037 1.00 663.76 ? 54  GLU A OE2   1 
ATOM   42   N N     . SER A 1 55  ? 88.378  116.282 143.041 1.00 734.99 ? 55  SER A N     1 
ATOM   43   C CA    . SER A 1 55  ? 88.467  117.666 142.605 1.00 734.99 ? 55  SER A CA    1 
ATOM   44   C C     . SER A 1 55  ? 89.026  118.612 143.657 1.00 734.99 ? 55  SER A C     1 
ATOM   45   O O     . SER A 1 55  ? 89.204  119.799 143.361 1.00 734.99 ? 55  SER A O     1 
ATOM   46   C CB    . SER A 1 55  ? 87.087  118.177 142.161 1.00 734.99 ? 55  SER A CB    1 
ATOM   47   O OG    . SER A 1 55  ? 86.140  118.060 143.208 1.00 734.99 ? 55  SER A OG    1 
ATOM   48   N N     . ARG A 1 56  ? 89.309  118.133 144.866 1.00 677.01 ? 56  ARG A N     1 
ATOM   49   C CA    . ARG A 1 56  ? 90.010  118.945 145.849 1.00 677.01 ? 56  ARG A CA    1 
ATOM   50   C C     . ARG A 1 56  ? 91.511  118.877 145.595 1.00 677.01 ? 56  ARG A C     1 
ATOM   51   O O     . ARG A 1 56  ? 91.999  118.007 144.868 1.00 677.01 ? 56  ARG A O     1 
ATOM   52   C CB    . ARG A 1 56  ? 89.695  118.463 147.264 1.00 677.01 ? 56  ARG A CB    1 
ATOM   53   C CG    . ARG A 1 56  ? 88.218  118.437 147.606 1.00 677.01 ? 56  ARG A CG    1 
ATOM   54   C CD    . ARG A 1 56  ? 87.972  117.599 148.849 1.00 677.01 ? 56  ARG A CD    1 
ATOM   55   N NE    . ARG A 1 56  ? 88.487  116.244 148.691 1.00 677.01 ? 56  ARG A NE    1 
ATOM   56   C CZ    . ARG A 1 56  ? 88.535  115.341 149.661 1.00 677.01 ? 56  ARG A CZ    1 
ATOM   57   N NH1   . ARG A 1 56  ? 89.035  114.137 149.402 1.00 677.01 ? 56  ARG A NH1   1 
ATOM   58   N NH2   . ARG A 1 56  ? 88.094  115.612 150.878 1.00 677.01 ? 56  ARG A NH2   1 
ATOM   59   N N     . PHE A 1 57  ? 92.254  119.800 146.206 1.00 663.16 ? 57  PHE A N     1 
ATOM   60   C CA    . PHE A 1 57  ? 93.692  119.815 145.988 1.00 663.16 ? 57  PHE A CA    1 
ATOM   61   C C     . PHE A 1 57  ? 94.402  120.573 147.099 1.00 663.16 ? 57  PHE A C     1 
ATOM   62   O O     . PHE A 1 57  ? 93.856  121.510 147.687 1.00 663.16 ? 57  PHE A O     1 
ATOM   63   C CB    . PHE A 1 57  ? 94.050  120.446 144.634 1.00 663.16 ? 57  PHE A CB    1 
ATOM   64   C CG    . PHE A 1 57  ? 93.712  121.910 144.533 1.00 663.16 ? 57  PHE A CG    1 
ATOM   65   C CD1   . PHE A 1 57  ? 94.632  122.878 144.907 1.00 663.16 ? 57  PHE A CD1   1 
ATOM   66   C CD2   . PHE A 1 57  ? 92.471  122.317 144.072 1.00 663.16 ? 57  PHE A CD2   1 
ATOM   67   C CE1   . PHE A 1 57  ? 94.325  124.220 144.820 1.00 663.16 ? 57  PHE A CE1   1 
ATOM   68   C CE2   . PHE A 1 57  ? 92.159  123.663 143.983 1.00 663.16 ? 57  PHE A CE2   1 
ATOM   69   C CZ    . PHE A 1 57  ? 93.087  124.614 144.358 1.00 663.16 ? 57  PHE A CZ    1 
ATOM   70   N N     . PHE A 1 58  ? 95.631  120.144 147.373 1.00 555.44 ? 58  PHE A N     1 
ATOM   71   C CA    . PHE A 1 58  ? 96.613  120.936 148.096 1.00 555.44 ? 58  PHE A CA    1 
ATOM   72   C C     . PHE A 1 58  ? 97.452  121.719 147.096 1.00 555.44 ? 58  PHE A C     1 
ATOM   73   O O     . PHE A 1 58  ? 97.708  121.246 145.985 1.00 555.44 ? 58  PHE A O     1 
ATOM   74   C CB    . PHE A 1 58  ? 97.530  120.064 148.956 1.00 555.44 ? 58  PHE A CB    1 
ATOM   75   C CG    . PHE A 1 58  ? 96.812  119.043 149.789 1.00 555.44 ? 58  PHE A CG    1 
ATOM   76   C CD1   . PHE A 1 58  ? 96.128  119.420 150.932 1.00 555.44 ? 58  PHE A CD1   1 
ATOM   77   C CD2   . PHE A 1 58  ? 96.845  117.701 149.447 1.00 555.44 ? 58  PHE A CD2   1 
ATOM   78   C CE1   . PHE A 1 58  ? 95.476  118.484 151.710 1.00 555.44 ? 58  PHE A CE1   1 
ATOM   79   C CE2   . PHE A 1 58  ? 96.195  116.758 150.220 1.00 555.44 ? 58  PHE A CE2   1 
ATOM   80   C CZ    . PHE A 1 58  ? 95.512  117.150 151.355 1.00 555.44 ? 58  PHE A CZ    1 
ATOM   81   N N     . ILE A 1 59  ? 97.882  122.914 147.489 1.00 368.61 ? 59  ILE A N     1 
ATOM   82   C CA    . ILE A 1 59  ? 98.816  123.699 146.692 1.00 368.61 ? 59  ILE A CA    1 
ATOM   83   C C     . ILE A 1 59  ? 100.093 123.880 147.499 1.00 368.61 ? 59  ILE A C     1 
ATOM   84   O O     . ILE A 1 59  ? 100.048 124.164 148.703 1.00 368.61 ? 59  ILE A O     1 
ATOM   85   C CB    . ILE A 1 59  ? 98.211  125.051 146.267 1.00 368.61 ? 59  ILE A CB    1 
ATOM   86   C CG1   . ILE A 1 59  ? 99.090  125.719 145.207 1.00 368.61 ? 59  ILE A CG1   1 
ATOM   87   C CG2   . ILE A 1 59  ? 97.974  125.967 147.464 1.00 368.61 ? 59  ILE A CG2   1 
ATOM   88   C CD1   . ILE A 1 59  ? 98.373  126.771 144.394 1.00 368.61 ? 59  ILE A CD1   1 
ATOM   89   N N     . ILE A 1 60  ? 101.228 123.666 146.841 1.00 331.60 ? 60  ILE A N     1 
ATOM   90   C CA    . ILE A 1 60  ? 102.538 123.666 147.478 1.00 331.60 ? 60  ILE A CA    1 
ATOM   91   C C     . ILE A 1 60  ? 103.315 124.886 147.010 1.00 331.60 ? 60  ILE A C     1 
ATOM   92   O O     . ILE A 1 60  ? 103.507 125.084 145.804 1.00 331.60 ? 60  ILE A O     1 
ATOM   93   C CB    . ILE A 1 60  ? 103.312 122.372 147.181 1.00 331.60 ? 60  ILE A CB    1 
ATOM   94   C CG1   . ILE A 1 60  ? 102.414 121.154 147.393 1.00 331.60 ? 60  ILE A CG1   1 
ATOM   95   C CG2   . ILE A 1 60  ? 104.518 122.273 148.085 1.00 331.60 ? 60  ILE A CG2   1 
ATOM   96   C CD1   . ILE A 1 60  ? 101.803 121.074 148.776 1.00 331.60 ? 60  ILE A CD1   1 
ATOM   97   N N     . ASN A 1 61  ? 103.758 125.700 147.961 1.00 348.75 ? 61  ASN A N     1 
ATOM   98   C CA    . ASN A 1 61  ? 104.603 126.845 147.664 1.00 348.75 ? 61  ASN A CA    1 
ATOM   99   C C     . ASN A 1 61  ? 105.576 127.023 148.821 1.00 348.75 ? 61  ASN A C     1 
ATOM   100  O O     . ASN A 1 61  ? 105.562 126.264 149.795 1.00 348.75 ? 61  ASN A O     1 
ATOM   101  C CB    . ASN A 1 61  ? 103.766 128.103 147.414 1.00 348.75 ? 61  ASN A CB    1 
ATOM   102  C CG    . ASN A 1 61  ? 102.803 128.402 148.547 1.00 348.75 ? 61  ASN A CG    1 
ATOM   103  O OD1   . ASN A 1 61  ? 103.216 128.683 149.672 1.00 348.75 ? 61  ASN A OD1   1 
ATOM   104  N ND2   . ASN A 1 61  ? 101.510 128.341 148.253 1.00 348.75 ? 61  ASN A ND2   1 
ATOM   105  N N     . ASP A 1 62  ? 106.437 128.036 148.706 1.00 442.52 ? 62  ASP A N     1 
ATOM   106  C CA    . ASP A 1 62  ? 107.450 128.257 149.731 1.00 442.52 ? 62  ASP A CA    1 
ATOM   107  C C     . ASP A 1 62  ? 106.822 128.701 151.042 1.00 442.52 ? 62  ASP A C     1 
ATOM   108  O O     . ASP A 1 62  ? 107.349 128.397 152.119 1.00 442.52 ? 62  ASP A O     1 
ATOM   109  C CB    . ASP A 1 62  ? 108.468 129.291 149.249 1.00 442.52 ? 62  ASP A CB    1 
ATOM   110  C CG    . ASP A 1 62  ? 109.273 128.807 148.060 1.00 442.52 ? 62  ASP A CG    1 
ATOM   111  O OD1   . ASP A 1 62  ? 109.492 127.583 147.948 1.00 442.52 ? 62  ASP A OD1   1 
ATOM   112  O OD2   . ASP A 1 62  ? 109.685 129.651 147.236 1.00 442.52 ? 62  ASP A OD2   1 
ATOM   113  N N     . ASN A 1 63  ? 105.699 129.414 150.976 1.00 408.15 ? 63  ASN A N     1 
ATOM   114  C CA    . ASN A 1 63  ? 105.108 130.029 152.155 1.00 408.15 ? 63  ASN A CA    1 
ATOM   115  C C     . ASN A 1 63  ? 104.295 129.055 152.994 1.00 408.15 ? 63  ASN A C     1 
ATOM   116  O O     . ASN A 1 63  ? 104.155 129.271 154.204 1.00 408.15 ? 63  ASN A O     1 
ATOM   117  C CB    . ASN A 1 63  ? 104.217 131.205 151.744 1.00 408.15 ? 63  ASN A CB    1 
ATOM   118  C CG    . ASN A 1 63  ? 104.969 132.257 150.956 1.00 408.15 ? 63  ASN A CG    1 
ATOM   119  O OD1   . ASN A 1 63  ? 106.179 132.421 151.116 1.00 408.15 ? 63  ASN A OD1   1 
ATOM   120  N ND2   . ASN A 1 63  ? 104.256 132.977 150.099 1.00 408.15 ? 63  ASN A ND2   1 
ATOM   121  N N     . ASN A 1 64  ? 103.757 127.992 152.393 1.00 326.19 ? 64  ASN A N     1 
ATOM   122  C CA    . ASN A 1 64  ? 102.881 127.070 153.105 1.00 326.19 ? 64  ASN A CA    1 
ATOM   123  C C     . ASN A 1 64  ? 103.407 125.639 153.133 1.00 326.19 ? 64  ASN A C     1 
ATOM   124  O O     . ASN A 1 64  ? 102.684 124.737 153.573 1.00 326.19 ? 64  ASN A O     1 
ATOM   125  C CB    . ASN A 1 64  ? 101.470 127.108 152.503 1.00 326.19 ? 64  ASN A CB    1 
ATOM   126  C CG    . ASN A 1 64  ? 101.412 126.565 151.076 1.00 326.19 ? 64  ASN A CG    1 
ATOM   127  O OD1   . ASN A 1 64  ? 102.395 126.051 150.541 1.00 326.19 ? 64  ASN A OD1   1 
ATOM   128  N ND2   . ASN A 1 64  ? 100.243 126.681 150.457 1.00 326.19 ? 64  ASN A ND2   1 
ATOM   129  N N     . TYR A 1 65  ? 104.627 125.405 152.645 1.00 342.88 ? 65  TYR A N     1 
ATOM   130  C CA    . TYR A 1 65  ? 105.163 124.053 152.544 1.00 342.88 ? 65  TYR A CA    1 
ATOM   131  C C     . TYR A 1 65  ? 105.080 123.324 153.880 1.00 342.88 ? 65  TYR A C     1 
ATOM   132  O O     . TYR A 1 65  ? 105.752 123.697 154.846 1.00 342.88 ? 65  TYR A O     1 
ATOM   133  C CB    . TYR A 1 65  ? 106.610 124.089 152.056 1.00 342.88 ? 65  TYR A CB    1 
ATOM   134  C CG    . TYR A 1 65  ? 107.281 122.737 152.101 1.00 342.88 ? 65  TYR A CG    1 
ATOM   135  C CD1   . TYR A 1 65  ? 106.785 121.672 151.361 1.00 342.88 ? 65  TYR A CD1   1 
ATOM   136  C CD2   . TYR A 1 65  ? 108.409 122.525 152.881 1.00 342.88 ? 65  TYR A CD2   1 
ATOM   137  C CE1   . TYR A 1 65  ? 107.393 120.432 151.398 1.00 342.88 ? 65  TYR A CE1   1 
ATOM   138  C CE2   . TYR A 1 65  ? 109.025 121.288 152.923 1.00 342.88 ? 65  TYR A CE2   1 
ATOM   139  C CZ    . TYR A 1 65  ? 108.512 120.246 152.181 1.00 342.88 ? 65  TYR A CZ    1 
ATOM   140  O OH    . TYR A 1 65  ? 109.123 119.012 152.219 1.00 342.88 ? 65  TYR A OH    1 
ATOM   141  N N     . ASN A 1 66  ? 104.254 122.282 153.932 1.00 375.31 ? 66  ASN A N     1 
ATOM   142  C CA    . ASN A 1 66  ? 104.112 121.442 155.115 1.00 375.31 ? 66  ASN A CA    1 
ATOM   143  C C     . ASN A 1 66  ? 104.748 120.091 154.817 1.00 375.31 ? 66  ASN A C     1 
ATOM   144  O O     . ASN A 1 66  ? 104.222 119.325 154.004 1.00 375.31 ? 66  ASN A O     1 
ATOM   145  C CB    . ASN A 1 66  ? 102.637 121.280 155.496 1.00 375.31 ? 66  ASN A CB    1 
ATOM   146  C CG    . ASN A 1 66  ? 102.429 120.372 156.702 1.00 375.31 ? 66  ASN A CG    1 
ATOM   147  O OD1   . ASN A 1 66  ? 103.379 119.843 157.281 1.00 375.31 ? 66  ASN A OD1   1 
ATOM   148  N ND2   . ASN A 1 66  ? 101.169 120.188 157.083 1.00 375.31 ? 66  ASN A ND2   1 
ATOM   149  N N     . GLU A 1 67  ? 105.882 119.810 155.467 1.00 376.95 ? 67  GLU A N     1 
ATOM   150  C CA    . GLU A 1 67  ? 106.618 118.577 155.198 1.00 376.95 ? 67  GLU A CA    1 
ATOM   151  C C     . GLU A 1 67  ? 105.746 117.338 155.364 1.00 376.95 ? 67  GLU A C     1 
ATOM   152  O O     . GLU A 1 67  ? 105.902 116.375 154.603 1.00 376.95 ? 67  GLU A O     1 
ATOM   153  C CB    . GLU A 1 67  ? 107.839 118.483 156.112 1.00 376.95 ? 67  GLU A CB    1 
ATOM   154  C CG    . GLU A 1 67  ? 108.723 117.274 155.845 1.00 376.95 ? 67  GLU A CG    1 
ATOM   155  C CD    . GLU A 1 67  ? 109.988 117.280 156.679 1.00 376.95 ? 67  GLU A CD    1 
ATOM   156  O OE1   . GLU A 1 67  ? 110.132 118.180 157.534 1.00 376.95 ? 67  GLU A OE1   1 
ATOM   157  O OE2   . GLU A 1 67  ? 110.836 116.386 156.481 1.00 376.95 ? 67  GLU A OE2   1 
ATOM   158  N N     . ASN A 1 68  ? 104.828 117.349 156.336 1.00 368.63 ? 68  ASN A N     1 
ATOM   159  C CA    . ASN A 1 68  ? 103.981 116.192 156.610 1.00 368.63 ? 68  ASN A CA    1 
ATOM   160  C C     . ASN A 1 68  ? 103.176 115.751 155.395 1.00 368.63 ? 68  ASN A C     1 
ATOM   161  O O     . ASN A 1 68  ? 102.659 114.628 155.383 1.00 368.63 ? 68  ASN A O     1 
ATOM   162  C CB    . ASN A 1 68  ? 103.038 116.496 157.775 1.00 368.63 ? 68  ASN A CB    1 
ATOM   163  C CG    . ASN A 1 68  ? 103.773 116.682 159.086 1.00 368.63 ? 68  ASN A CG    1 
ATOM   164  O OD1   . ASN A 1 68  ? 104.814 116.068 159.319 1.00 368.63 ? 68  ASN A OD1   1 
ATOM   165  N ND2   . ASN A 1 68  ? 103.235 117.534 159.950 1.00 368.63 ? 68  ASN A ND2   1 
ATOM   166  N N     . ILE A 1 69  ? 103.080 116.598 154.365 1.00 433.44 ? 69  ILE A N     1 
ATOM   167  C CA    . ILE A 1 69  ? 102.355 116.222 153.157 1.00 433.44 ? 69  ILE A CA    1 
ATOM   168  C C     . ILE A 1 69  ? 103.009 115.004 152.520 1.00 433.44 ? 69  ILE A C     1 
ATOM   169  O O     . ILE A 1 69  ? 102.324 114.144 151.950 1.00 433.44 ? 69  ILE A O     1 
ATOM   170  C CB    . ILE A 1 69  ? 102.278 117.419 152.181 1.00 433.44 ? 69  ILE A CB    1 
ATOM   171  C CG1   . ILE A 1 69  ? 101.139 117.233 151.178 1.00 433.44 ? 69  ILE A CG1   1 
ATOM   172  C CG2   . ILE A 1 69  ? 103.593 117.625 151.436 1.00 433.44 ? 69  ILE A CG2   1 
ATOM   173  C CD1   . ILE A 1 69  ? 99.769  117.465 151.774 1.00 433.44 ? 69  ILE A CD1   1 
ATOM   174  N N     . ASN A 1 70  ? 104.335 114.885 152.644 1.00 425.07 ? 70  ASN A N     1 
ATOM   175  C CA    . ASN A 1 70  ? 105.035 113.747 152.065 1.00 425.07 ? 70  ASN A CA    1 
ATOM   176  C C     . ASN A 1 70  ? 104.615 112.437 152.713 1.00 425.07 ? 70  ASN A C     1 
ATOM   177  O O     . ASN A 1 70  ? 104.819 111.374 152.116 1.00 425.07 ? 70  ASN A O     1 
ATOM   178  C CB    . ASN A 1 70  ? 106.547 113.935 152.202 1.00 425.07 ? 70  ASN A CB    1 
ATOM   179  C CG    . ASN A 1 70  ? 107.084 115.021 151.293 1.00 425.07 ? 70  ASN A CG    1 
ATOM   180  O OD1   . ASN A 1 70  ? 106.604 115.203 150.173 1.00 425.07 ? 70  ASN A OD1   1 
ATOM   181  N ND2   . ASN A 1 70  ? 108.084 115.751 151.770 1.00 425.07 ? 70  ASN A ND2   1 
ATOM   182  N N     . LEU A 1 71  ? 104.001 112.490 153.899 1.00 409.81 ? 71  LEU A N     1 
ATOM   183  C CA    . LEU A 1 71  ? 103.545 111.257 154.526 1.00 409.81 ? 71  LEU A CA    1 
ATOM   184  C C     . LEU A 1 71  ? 102.376 110.646 153.769 1.00 409.81 ? 71  LEU A C     1 
ATOM   185  O O     . LEU A 1 71  ? 102.018 109.493 154.029 1.00 409.81 ? 71  LEU A O     1 
ATOM   186  C CB    . LEU A 1 71  ? 103.150 111.520 155.979 1.00 409.81 ? 71  LEU A CB    1 
ATOM   187  C CG    . LEU A 1 71  ? 104.251 112.078 156.883 1.00 409.81 ? 71  LEU A CG    1 
ATOM   188  C CD1   . LEU A 1 71  ? 103.714 112.342 158.280 1.00 409.81 ? 71  LEU A CD1   1 
ATOM   189  C CD2   . LEU A 1 71  ? 105.440 111.133 156.929 1.00 409.81 ? 71  LEU A CD2   1 
ATOM   190  N N     . ILE A 1 72  ? 101.776 111.395 152.842 1.00 461.67 ? 72  ILE A N     1 
ATOM   191  C CA    . ILE A 1 72  ? 100.752 110.820 151.979 1.00 461.67 ? 72  ILE A CA    1 
ATOM   192  C C     . ILE A 1 72  ? 101.387 109.826 151.014 1.00 461.67 ? 72  ILE A C     1 
ATOM   193  O O     . ILE A 1 72  ? 100.749 108.848 150.603 1.00 461.67 ? 72  ILE A O     1 
ATOM   194  C CB    . ILE A 1 72  ? 99.973  111.927 151.245 1.00 461.67 ? 72  ILE A CB    1 
ATOM   195  C CG1   . ILE A 1 72  ? 99.337  112.880 152.256 1.00 461.67 ? 72  ILE A CG1   1 
ATOM   196  C CG2   . ILE A 1 72  ? 98.893  111.335 150.358 1.00 461.67 ? 72  ILE A CG2   1 
ATOM   197  C CD1   . ILE A 1 72  ? 98.711  114.094 151.627 1.00 461.67 ? 72  ILE A CD1   1 
ATOM   198  N N     . TYR A 1 73  ? 102.655 110.044 150.658 1.00 457.84 ? 73  TYR A N     1 
ATOM   199  C CA    . TYR A 1 73  ? 103.360 109.175 149.724 1.00 457.84 ? 73  TYR A CA    1 
ATOM   200  C C     . TYR A 1 73  ? 103.730 107.824 150.321 1.00 457.84 ? 73  TYR A C     1 
ATOM   201  O O     . TYR A 1 73  ? 104.218 106.958 149.589 1.00 457.84 ? 73  TYR A O     1 
ATOM   202  C CB    . TYR A 1 73  ? 104.632 109.867 149.225 1.00 457.84 ? 73  TYR A CB    1 
ATOM   203  C CG    . TYR A 1 73  ? 104.387 111.176 148.514 1.00 457.84 ? 73  TYR A CG    1 
ATOM   204  C CD1   . TYR A 1 73  ? 103.225 111.389 147.784 1.00 457.84 ? 73  TYR A CD1   1 
ATOM   205  C CD2   . TYR A 1 73  ? 105.320 112.203 148.573 1.00 457.84 ? 73  TYR A CD2   1 
ATOM   206  C CE1   . TYR A 1 73  ? 103.000 112.585 147.132 1.00 457.84 ? 73  TYR A CE1   1 
ATOM   207  C CE2   . TYR A 1 73  ? 105.104 113.403 147.923 1.00 457.84 ? 73  TYR A CE2   1 
ATOM   208  C CZ    . TYR A 1 73  ? 103.942 113.588 147.204 1.00 457.84 ? 73  TYR A CZ    1 
ATOM   209  O OH    . TYR A 1 73  ? 103.723 114.783 146.557 1.00 457.84 ? 73  TYR A OH    1 
ATOM   210  N N     . LYS A 1 74  ? 103.518 107.626 151.620 1.00 420.86 ? 74  LYS A N     1 
ATOM   211  C CA    . LYS A 1 74  ? 104.017 106.434 152.293 1.00 420.86 ? 74  LYS A CA    1 
ATOM   212  C C     . LYS A 1 74  ? 103.214 105.214 151.852 1.00 420.86 ? 74  LYS A C     1 
ATOM   213  O O     . LYS A 1 74  ? 101.991 105.172 152.023 1.00 420.86 ? 74  LYS A O     1 
ATOM   214  C CB    . LYS A 1 74  ? 103.935 106.611 153.807 1.00 420.86 ? 74  LYS A CB    1 
ATOM   215  C CG    . LYS A 1 74  ? 104.633 105.516 154.597 1.00 420.86 ? 74  LYS A CG    1 
ATOM   216  C CD    . LYS A 1 74  ? 104.795 105.906 156.055 1.00 420.86 ? 74  LYS A CD    1 
ATOM   217  C CE    . LYS A 1 74  ? 105.547 104.836 156.830 1.00 420.86 ? 74  LYS A CE    1 
ATOM   218  N NZ    . LYS A 1 74  ? 105.624 105.152 158.283 1.00 420.86 ? 74  LYS A NZ    1 
ATOM   219  N N     . ASP A 1 75  ? 103.904 104.230 151.277 1.00 428.13 ? 75  ASP A N     1 
ATOM   220  C CA    . ASP A 1 75  ? 103.377 102.909 150.927 1.00 428.13 ? 75  ASP A CA    1 
ATOM   221  C C     . ASP A 1 75  ? 102.290 102.978 149.864 1.00 428.13 ? 75  ASP A C     1 
ATOM   222  O O     . ASP A 1 75  ? 101.299 102.239 149.959 1.00 428.13 ? 75  ASP A O     1 
ATOM   223  C CB    . ASP A 1 75  ? 102.829 102.165 152.151 1.00 428.13 ? 75  ASP A CB    1 
ATOM   224  C CG    . ASP A 1 75  ? 103.910 101.817 153.155 1.00 428.13 ? 75  ASP A CG    1 
ATOM   225  O OD1   . ASP A 1 75  ? 104.932 101.223 152.751 1.00 428.13 ? 75  ASP A OD1   1 
ATOM   226  O OD2   . ASP A 1 75  ? 103.738 102.139 154.350 1.00 428.13 ? 75  ASP A OD2   1 
ATOM   227  N N     . ILE A 1 76  ? 102.437 103.835 148.851 1.00 422.27 ? 76  ILE A N     1 
ATOM   228  C CA    . ILE A 1 76  ? 101.506 103.830 147.730 1.00 422.27 ? 76  ILE A CA    1 
ATOM   229  C C     . ILE A 1 76  ? 102.067 102.991 146.588 1.00 422.27 ? 76  ILE A C     1 
ATOM   230  O O     . ILE A 1 76  ? 103.287 102.825 146.444 1.00 422.27 ? 76  ILE A O     1 
ATOM   231  C CB    . ILE A 1 76  ? 101.205 105.268 147.269 1.00 422.27 ? 76  ILE A CB    1 
ATOM   232  C CG1   . ILE A 1 76  ? 102.484 105.952 146.782 1.00 422.27 ? 76  ILE A CG1   1 
ATOM   233  C CG2   . ILE A 1 76  ? 100.566 106.065 148.398 1.00 422.27 ? 76  ILE A CG2   1 
ATOM   234  C CD1   . ILE A 1 76  ? 102.251 107.312 146.163 1.00 422.27 ? 76  ILE A CD1   1 
ATOM   235  N N     . LYS A 1 77  ? 101.167 102.452 145.767 1.00 393.27 ? 77  LYS A N     1 
ATOM   236  C CA    . LYS A 1 77  ? 101.555 101.635 144.624 1.00 393.27 ? 77  LYS A CA    1 
ATOM   237  C C     . LYS A 1 77  ? 101.433 102.362 143.293 1.00 393.27 ? 77  LYS A C     1 
ATOM   238  O O     . LYS A 1 77  ? 102.231 102.104 142.386 1.00 393.27 ? 77  LYS A O     1 
ATOM   239  C CB    . LYS A 1 77  ? 100.707 100.358 144.572 1.00 393.27 ? 77  LYS A CB    1 
ATOM   240  C CG    . LYS A 1 77  ? 100.841 99.473  145.802 1.00 393.27 ? 77  LYS A CG    1 
ATOM   241  C CD    . LYS A 1 77  ? 99.998  98.215  145.669 1.00 393.27 ? 77  LYS A CD    1 
ATOM   242  C CE    . LYS A 1 77  ? 100.103 97.347  146.913 1.00 393.27 ? 77  LYS A CE    1 
ATOM   243  N NZ    . LYS A 1 77  ? 99.294  96.102  146.790 1.00 393.27 ? 77  LYS A NZ    1 
ATOM   244  N N     . TYR A 1 78  ? 100.461 103.261 143.153 1.00 413.14 ? 78  TYR A N     1 
ATOM   245  C CA    . TYR A 1 78  ? 100.289 104.010 141.919 1.00 413.14 ? 78  TYR A CA    1 
ATOM   246  C C     . TYR A 1 78  ? 99.671  105.362 142.243 1.00 413.14 ? 78  TYR A C     1 
ATOM   247  O O     . TYR A 1 78  ? 99.053  105.550 143.295 1.00 413.14 ? 78  TYR A O     1 
ATOM   248  C CB    . TYR A 1 78  ? 99.439  103.244 140.899 1.00 413.14 ? 78  TYR A CB    1 
ATOM   249  C CG    . TYR A 1 78  ? 98.096  102.788 141.420 1.00 413.14 ? 78  TYR A CG    1 
ATOM   250  C CD1   . TYR A 1 78  ? 97.002  103.642 141.417 1.00 413.14 ? 78  TYR A CD1   1 
ATOM   251  C CD2   . TYR A 1 78  ? 97.927  101.506 141.925 1.00 413.14 ? 78  TYR A CD2   1 
ATOM   252  C CE1   . TYR A 1 78  ? 95.776  103.231 141.891 1.00 413.14 ? 78  TYR A CE1   1 
ATOM   253  C CE2   . TYR A 1 78  ? 96.701  101.086 142.404 1.00 413.14 ? 78  TYR A CE2   1 
ATOM   254  C CZ    . TYR A 1 78  ? 95.629  101.953 142.385 1.00 413.14 ? 78  TYR A CZ    1 
ATOM   255  O OH    . TYR A 1 78  ? 94.407  101.539 142.861 1.00 413.14 ? 78  TYR A OH    1 
ATOM   256  N N     . CYS A 1 79  ? 99.840  106.303 141.318 1.00 380.91 ? 79  CYS A N     1 
ATOM   257  C CA    . CYS A 1 79  ? 99.290  107.641 141.459 1.00 380.91 ? 79  CYS A CA    1 
ATOM   258  C C     . CYS A 1 79  ? 99.154  108.274 140.082 1.00 380.91 ? 79  CYS A C     1 
ATOM   259  O O     . CYS A 1 79  ? 99.979  108.043 139.194 1.00 380.91 ? 79  CYS A O     1 
ATOM   260  C CB    . CYS A 1 79  ? 100.164 108.516 142.367 1.00 380.91 ? 79  CYS A CB    1 
ATOM   261  S SG    . CYS A 1 79  ? 101.782 108.934 141.677 1.00 380.91 ? 79  CYS A SG    1 
ATOM   262  N N     . GLY A 1 80  ? 98.096  109.066 139.909 1.00 394.93 ? 80  GLY A N     1 
ATOM   263  C CA    . GLY A 1 80  ? 97.947  109.848 138.692 1.00 394.93 ? 80  GLY A CA    1 
ATOM   264  C C     . GLY A 1 80  ? 98.908  111.022 138.696 1.00 394.93 ? 80  GLY A C     1 
ATOM   265  O O     . GLY A 1 80  ? 99.003  111.761 139.682 1.00 394.93 ? 80  GLY A O     1 
ATOM   266  N N     . LEU A 1 81  ? 99.623  111.195 137.587 1.00 469.36 ? 81  LEU A N     1 
ATOM   267  C CA    . LEU A 1 81  ? 100.588 112.273 137.413 1.00 469.36 ? 81  LEU A CA    1 
ATOM   268  C C     . LEU A 1 81  ? 100.256 113.092 136.175 1.00 469.36 ? 81  LEU A C     1 
ATOM   269  O O     . LEU A 1 81  ? 100.087 112.538 135.084 1.00 469.36 ? 81  LEU A O     1 
ATOM   270  C CB    . LEU A 1 81  ? 102.014 111.722 137.312 1.00 469.36 ? 81  LEU A CB    1 
ATOM   271  C CG    . LEU A 1 81  ? 103.100 112.703 136.859 1.00 469.36 ? 81  LEU A CG    1 
ATOM   272  C CD1   . LEU A 1 81  ? 103.209 113.878 137.816 1.00 469.36 ? 81  LEU A CD1   1 
ATOM   273  C CD2   . LEU A 1 81  ? 104.442 112.001 136.731 1.00 469.36 ? 81  LEU A CD2   1 
ATOM   274  N N     . ASN A 1 82  ? 100.164 114.409 136.348 1.00 419.68 ? 82  ASN A N     1 
ATOM   275  C CA    . ASN A 1 82  ? 100.041 115.332 135.232 1.00 419.68 ? 82  ASN A CA    1 
ATOM   276  C C     . ASN A 1 82  ? 100.823 116.595 135.558 1.00 419.68 ? 82  ASN A C     1 
ATOM   277  O O     . ASN A 1 82  ? 101.143 116.864 136.719 1.00 419.68 ? 82  ASN A O     1 
ATOM   278  C CB    . ASN A 1 82  ? 98.570  115.673 134.943 1.00 419.68 ? 82  ASN A CB    1 
ATOM   279  C CG    . ASN A 1 82  ? 98.378  116.358 133.602 1.00 419.68 ? 82  ASN A CG    1 
ATOM   280  O OD1   . ASN A 1 82  ? 99.250  116.309 132.734 1.00 419.68 ? 82  ASN A OD1   1 
ATOM   281  N ND2   . ASN A 1 82  ? 97.233  117.007 133.431 1.00 419.68 ? 82  ASN A ND2   1 
ATOM   282  N N     . ILE A 1 83  ? 101.122 117.374 134.520 1.00 416.48 ? 83  ILE A N     1 
ATOM   283  C CA    . ILE A 1 83  ? 101.774 118.667 134.665 1.00 416.48 ? 83  ILE A CA    1 
ATOM   284  C C     . ILE A 1 83  ? 101.064 119.677 133.779 1.00 416.48 ? 83  ILE A C     1 
ATOM   285  O O     . ILE A 1 83  ? 100.365 119.319 132.825 1.00 416.48 ? 83  ILE A O     1 
ATOM   286  C CB    . ILE A 1 83  ? 103.280 118.626 134.318 1.00 416.48 ? 83  ILE A CB    1 
ATOM   287  C CG1   . ILE A 1 83  ? 103.483 118.346 132.829 1.00 416.48 ? 83  ILE A CG1   1 
ATOM   288  C CG2   . ILE A 1 83  ? 104.008 117.592 135.166 1.00 416.48 ? 83  ILE A CG2   1 
ATOM   289  C CD1   . ILE A 1 83  ? 104.923 118.452 132.386 1.00 416.48 ? 83  ILE A CD1   1 
ATOM   290  N N     . GLN A 1 84  ? 101.244 120.949 134.112 1.00 412.75 ? 84  GLN A N     1 
ATOM   291  C CA    . GLN A 1 84  ? 100.838 122.061 133.266 1.00 412.75 ? 84  GLN A CA    1 
ATOM   292  C C     . GLN A 1 84  ? 102.082 122.845 132.876 1.00 412.75 ? 84  GLN A C     1 
ATOM   293  O O     . GLN A 1 84  ? 102.918 123.152 133.730 1.00 412.75 ? 84  GLN A O     1 
ATOM   294  C CB    . GLN A 1 84  ? 99.839  122.967 133.986 1.00 412.75 ? 84  GLN A CB    1 
ATOM   295  C CG    . GLN A 1 84  ? 98.635  122.232 134.550 1.00 412.75 ? 84  GLN A CG    1 
ATOM   296  C CD    . GLN A 1 84  ? 97.777  121.597 133.475 1.00 412.75 ? 84  GLN A CD    1 
ATOM   297  O OE1   . GLN A 1 84  ? 97.799  122.014 132.316 1.00 412.75 ? 84  GLN A OE1   1 
ATOM   298  N NE2   . GLN A 1 84  ? 97.017  120.579 133.855 1.00 412.75 ? 84  GLN A NE2   1 
ATOM   299  N N     . THR A 1 85  ? 102.242 123.098 131.581 1.00 353.04 ? 85  THR A N     1 
ATOM   300  C CA    . THR A 1 85  ? 103.372 123.854 131.065 1.00 353.04 ? 85  THR A CA    1 
ATOM   301  C C     . THR A 1 85  ? 102.906 125.179 130.483 1.00 353.04 ? 85  THR A C     1 
ATOM   302  O O     . THR A 1 85  ? 101.716 125.394 130.234 1.00 353.04 ? 85  THR A O     1 
ATOM   303  C CB    . THR A 1 85  ? 104.139 123.063 130.005 1.00 353.04 ? 85  THR A CB    1 
ATOM   304  O OG1   . THR A 1 85  ? 103.284 122.818 128.883 1.00 353.04 ? 85  THR A OG1   1 
ATOM   305  C CG2   . THR A 1 85  ? 104.612 121.745 130.588 1.00 353.04 ? 85  THR A CG2   1 
ATOM   306  N N     . THR A 1 86  ? 103.872 126.069 130.264 1.00 326.89 ? 86  THR A N     1 
ATOM   307  C CA    . THR A 1 86  ? 103.613 127.346 129.614 1.00 326.89 ? 86  THR A CA    1 
ATOM   308  C C     . THR A 1 86  ? 103.619 127.258 128.092 1.00 326.89 ? 86  THR A C     1 
ATOM   309  O O     . THR A 1 86  ? 103.186 128.209 127.435 1.00 326.89 ? 86  THR A O     1 
ATOM   310  C CB    . THR A 1 86  ? 104.644 128.385 130.063 1.00 326.89 ? 86  THR A CB    1 
ATOM   311  O OG1   . THR A 1 86  ? 105.963 127.915 129.751 1.00 326.89 ? 86  THR A OG1   1 
ATOM   312  C CG2   . THR A 1 86  ? 104.540 128.626 131.561 1.00 326.89 ? 86  THR A CG2   1 
ATOM   313  N N     . GLY A 1 87  ? 104.093 126.158 127.519 1.00 277.70 ? 87  GLY A N     1 
ATOM   314  C CA    . GLY A 1 87  ? 104.038 126.002 126.080 1.00 277.70 ? 87  GLY A CA    1 
ATOM   315  C C     . GLY A 1 87  ? 104.385 124.588 125.670 1.00 277.70 ? 87  GLY A C     1 
ATOM   316  O O     . GLY A 1 87  ? 104.462 123.679 126.501 1.00 277.70 ? 87  GLY A O     1 
ATOM   317  N N     . LEU A 1 88  ? 104.597 124.416 124.364 1.00 263.28 ? 88  LEU A N     1 
ATOM   318  C CA    . LEU A 1 88  ? 104.768 123.100 123.762 1.00 263.28 ? 88  LEU A CA    1 
ATOM   319  C C     . LEU A 1 88  ? 106.215 122.650 123.622 1.00 263.28 ? 88  LEU A C     1 
ATOM   320  O O     . LEU A 1 88  ? 106.463 121.439 123.611 1.00 263.28 ? 88  LEU A O     1 
ATOM   321  C CB    . LEU A 1 88  ? 104.112 123.059 122.374 1.00 263.28 ? 88  LEU A CB    1 
ATOM   322  C CG    . LEU A 1 88  ? 102.597 123.263 122.328 1.00 263.28 ? 88  LEU A CG    1 
ATOM   323  C CD1   . LEU A 1 88  ? 102.109 123.296 120.890 1.00 263.28 ? 88  LEU A CD1   1 
ATOM   324  C CD2   . LEU A 1 88  ? 101.889 122.170 123.112 1.00 263.28 ? 88  LEU A CD2   1 
ATOM   325  N N     . GLU A 1 89  ? 107.169 123.570 123.514 1.00 302.22 ? 89  GLU A N     1 
ATOM   326  C CA    . GLU A 1 89  ? 108.559 123.204 123.275 1.00 302.22 ? 89  GLU A CA    1 
ATOM   327  C C     . GLU A 1 89  ? 109.275 123.016 124.605 1.00 302.22 ? 89  GLU A C     1 
ATOM   328  O O     . GLU A 1 89  ? 109.378 123.958 125.400 1.00 302.22 ? 89  GLU A O     1 
ATOM   329  C CB    . GLU A 1 89  ? 109.258 124.275 122.437 1.00 302.22 ? 89  GLU A CB    1 
ATOM   330  C CG    . GLU A 1 89  ? 108.799 124.328 120.990 1.00 302.22 ? 89  GLU A CG    1 
ATOM   331  C CD    . GLU A 1 89  ? 108.975 123.005 120.274 1.00 302.22 ? 89  GLU A CD    1 
ATOM   332  O OE1   . GLU A 1 89  ? 109.966 122.299 120.558 1.00 302.22 ? 89  GLU A OE1   1 
ATOM   333  O OE2   . GLU A 1 89  ? 108.120 122.670 119.428 1.00 302.22 ? 89  GLU A OE2   1 
ATOM   334  N N     . VAL A 1 90  ? 109.777 121.802 124.842 1.00 397.96 ? 90  VAL A N     1 
ATOM   335  C CA    . VAL A 1 90  ? 110.382 121.482 126.132 1.00 397.96 ? 90  VAL A CA    1 
ATOM   336  C C     . VAL A 1 90  ? 111.614 122.345 126.377 1.00 397.96 ? 90  VAL A C     1 
ATOM   337  O O     . VAL A 1 90  ? 111.959 122.641 127.529 1.00 397.96 ? 90  VAL A O     1 
ATOM   338  C CB    . VAL A 1 90  ? 110.713 119.979 126.196 1.00 397.96 ? 90  VAL A CB    1 
ATOM   339  C CG1   . VAL A 1 90  ? 111.648 119.585 125.058 1.00 397.96 ? 90  VAL A CG1   1 
ATOM   340  C CG2   . VAL A 1 90  ? 111.301 119.603 127.547 1.00 397.96 ? 90  VAL A CG2   1 
ATOM   341  N N     . PHE A 1 91  ? 112.280 122.784 125.311 1.00 382.76 ? 91  PHE A N     1 
ATOM   342  C CA    . PHE A 1 91  ? 113.499 123.568 125.439 1.00 382.76 ? 91  PHE A CA    1 
ATOM   343  C C     . PHE A 1 91  ? 113.217 125.040 125.702 1.00 382.76 ? 91  PHE A C     1 
ATOM   344  O O     . PHE A 1 91  ? 114.049 125.718 126.314 1.00 382.76 ? 91  PHE A O     1 
ATOM   345  C CB    . PHE A 1 91  ? 114.350 123.424 124.176 1.00 382.76 ? 91  PHE A CB    1 
ATOM   346  C CG    . PHE A 1 91  ? 114.976 122.070 124.020 1.00 382.76 ? 91  PHE A CG    1 
ATOM   347  C CD1   . PHE A 1 91  ? 115.681 121.491 125.061 1.00 382.76 ? 91  PHE A CD1   1 
ATOM   348  C CD2   . PHE A 1 91  ? 114.856 121.371 122.830 1.00 382.76 ? 91  PHE A CD2   1 
ATOM   349  C CE1   . PHE A 1 91  ? 116.257 120.243 124.919 1.00 382.76 ? 91  PHE A CE1   1 
ATOM   350  C CE2   . PHE A 1 91  ? 115.430 120.124 122.680 1.00 382.76 ? 91  PHE A CE2   1 
ATOM   351  C CZ    . PHE A 1 91  ? 116.131 119.560 123.726 1.00 382.76 ? 91  PHE A CZ    1 
ATOM   352  N N     . ASP A 1 92  ? 112.066 125.541 125.253 1.00 403.60 ? 92  ASP A N     1 
ATOM   353  C CA    . ASP A 1 92  ? 111.724 126.948 125.369 1.00 403.60 ? 92  ASP A CA    1 
ATOM   354  C C     . ASP A 1 92  ? 110.734 127.277 126.478 1.00 403.60 ? 92  ASP A C     1 
ATOM   355  O O     . ASP A 1 92  ? 110.440 128.461 126.680 1.00 403.60 ? 92  ASP A O     1 
ATOM   356  C CB    . ASP A 1 92  ? 111.155 127.463 124.037 1.00 403.60 ? 92  ASP A CB    1 
ATOM   357  C CG    . ASP A 1 92  ? 112.107 127.243 122.881 1.00 403.60 ? 92  ASP A CG    1 
ATOM   358  O OD1   . ASP A 1 92  ? 113.306 127.015 123.139 1.00 403.60 ? 92  ASP A OD1   1 
ATOM   359  O OD2   . ASP A 1 92  ? 111.654 127.290 121.719 1.00 403.60 ? 92  ASP A OD2   1 
ATOM   360  N N     . GLU A 1 93  ? 110.208 126.288 127.197 1.00 324.77 ? 93  GLU A N     1 
ATOM   361  C CA    . GLU A 1 93  ? 109.092 126.516 128.100 1.00 324.77 ? 93  GLU A CA    1 
ATOM   362  C C     . GLU A 1 93  ? 109.407 125.964 129.483 1.00 324.77 ? 93  GLU A C     1 
ATOM   363  O O     . GLU A 1 93  ? 110.388 125.240 129.681 1.00 324.77 ? 93  GLU A O     1 
ATOM   364  C CB    . GLU A 1 93  ? 107.806 125.876 127.560 1.00 324.77 ? 93  GLU A CB    1 
ATOM   365  C CG    . GLU A 1 93  ? 107.461 126.293 126.139 1.00 324.77 ? 93  GLU A CG    1 
ATOM   366  C CD    . GLU A 1 93  ? 107.055 127.750 126.023 1.00 324.77 ? 93  GLU A CD    1 
ATOM   367  O OE1   . GLU A 1 93  ? 106.833 128.404 127.064 1.00 324.77 ? 93  GLU A OE1   1 
ATOM   368  O OE2   . GLU A 1 93  ? 106.957 128.243 124.880 1.00 324.77 ? 93  GLU A OE2   1 
ATOM   369  N N     . ASN A 1 94  ? 108.558 126.329 130.442 1.00 336.65 ? 94  ASN A N     1 
ATOM   370  C CA    . ASN A 1 94  ? 108.739 125.974 131.842 1.00 336.65 ? 94  ASN A CA    1 
ATOM   371  C C     . ASN A 1 94  ? 107.530 125.210 132.371 1.00 336.65 ? 94  ASN A C     1 
ATOM   372  O O     . ASN A 1 94  ? 106.425 125.295 131.824 1.00 336.65 ? 94  ASN A O     1 
ATOM   373  C CB    . ASN A 1 94  ? 108.979 127.226 132.697 1.00 336.65 ? 94  ASN A CB    1 
ATOM   374  C CG    . ASN A 1 94  ? 110.324 127.878 132.415 1.00 336.65 ? 94  ASN A CG    1 
ATOM   375  O OD1   . ASN A 1 94  ? 111.356 127.458 132.940 1.00 336.65 ? 94  ASN A OD1   1 
ATOM   376  N ND2   . ASN A 1 94  ? 110.315 128.910 131.581 1.00 336.65 ? 94  ASN A ND2   1 
ATOM   377  N N     . ILE A 1 95  ? 107.773 124.447 133.438 1.00 301.16 ? 95  ILE A N     1 
ATOM   378  C CA    . ILE A 1 95  ? 106.724 123.746 134.171 1.00 301.16 ? 95  ILE A CA    1 
ATOM   379  C C     . ILE A 1 95  ? 106.050 124.700 135.149 1.00 301.16 ? 95  ILE A C     1 
ATOM   380  O O     . ILE A 1 95  ? 106.685 125.202 136.085 1.00 301.16 ? 95  ILE A O     1 
ATOM   381  C CB    . ILE A 1 95  ? 107.311 122.531 134.909 1.00 301.16 ? 95  ILE A CB    1 
ATOM   382  C CG1   . ILE A 1 95  ? 107.889 121.524 133.915 1.00 301.16 ? 95  ILE A CG1   1 
ATOM   383  C CG2   . ILE A 1 95  ? 106.251 121.861 135.770 1.00 301.16 ? 95  ILE A CG2   1 
ATOM   384  C CD1   . ILE A 1 95  ? 108.607 120.353 134.582 1.00 301.16 ? 95  ILE A CD1   1 
ATOM   385  N N     . ARG A 1 96  ? 104.769 124.990 134.916 1.00 335.62 ? 96  ARG A N     1 
ATOM   386  C CA    . ARG A 1 96  ? 103.982 125.887 135.753 1.00 335.62 ? 96  ARG A CA    1 
ATOM   387  C C     . ARG A 1 96  ? 103.429 125.160 136.972 1.00 335.62 ? 96  ARG A C     1 
ATOM   388  O O     . ARG A 1 96  ? 103.383 125.716 138.074 1.00 335.62 ? 96  ARG A O     1 
ATOM   389  C CB    . ARG A 1 96  ? 102.835 126.491 134.936 1.00 335.62 ? 96  ARG A CB    1 
ATOM   390  C CG    . ARG A 1 96  ? 101.941 127.453 135.687 1.00 335.62 ? 96  ARG A CG    1 
ATOM   391  C CD    . ARG A 1 96  ? 102.739 128.601 136.211 1.00 335.62 ? 96  ARG A CD    1 
ATOM   392  N NE    . ARG A 1 96  ? 101.905 129.553 136.928 1.00 335.62 ? 96  ARG A NE    1 
ATOM   393  C CZ    . ARG A 1 96  ? 101.672 129.507 138.230 1.00 335.62 ? 96  ARG A CZ    1 
ATOM   394  N NH1   . ARG A 1 96  ? 100.911 130.446 138.785 1.00 335.62 ? 96  ARG A NH1   1 
ATOM   395  N NH2   . ARG A 1 96  ? 102.178 128.551 138.989 1.00 335.62 ? 96  ARG A NH2   1 
ATOM   396  N N     . LEU A 1 97  ? 102.987 123.925 136.784 1.00 379.05 ? 97  LEU A N     1 
ATOM   397  C CA    . LEU A 1 97  ? 102.426 123.150 137.876 1.00 379.05 ? 97  LEU A CA    1 
ATOM   398  C C     . LEU A 1 97  ? 102.888 121.704 137.799 1.00 379.05 ? 97  LEU A C     1 
ATOM   399  O O     . LEU A 1 97  ? 103.264 121.208 136.732 1.00 379.05 ? 97  LEU A O     1 
ATOM   400  C CB    . LEU A 1 97  ? 100.895 123.202 137.863 1.00 379.05 ? 97  LEU A CB    1 
ATOM   401  C CG    . LEU A 1 97  ? 100.198 124.555 138.075 1.00 379.05 ? 97  LEU A CG    1 
ATOM   402  C CD1   . LEU A 1 97  ? 98.672  124.435 137.992 1.00 379.05 ? 97  LEU A CD1   1 
ATOM   403  C CD2   . LEU A 1 97  ? 100.609 125.202 139.404 1.00 379.05 ? 97  LEU A CD2   1 
ATOM   404  N N     . ILE A 1 98  ? 102.873 121.042 138.949 1.00 425.00 ? 98  ILE A N     1 
ATOM   405  C CA    . ILE A 1 98  ? 103.021 119.595 139.040 1.00 425.00 ? 98  ILE A CA    1 
ATOM   406  C C     . ILE A 1 98  ? 101.897 119.037 139.895 1.00 425.00 ? 98  ILE A C     1 
ATOM   407  O O     . ILE A 1 98  ? 101.674 119.490 141.023 1.00 425.00 ? 98  ILE A O     1 
ATOM   408  C CB    . ILE A 1 98  ? 104.403 119.187 139.571 1.00 425.00 ? 98  ILE A CB    1 
ATOM   409  C CG1   . ILE A 1 98  ? 105.506 119.674 138.633 1.00 425.00 ? 98  ILE A CG1   1 
ATOM   410  C CG2   . ILE A 1 98  ? 104.494 117.703 139.786 1.00 425.00 ? 98  ILE A CG2   1 
ATOM   411  C CD1   . ILE A 1 98  ? 106.881 119.407 139.165 1.00 425.00 ? 98  ILE A CD1   1 
ATOM   412  N N     . GLN A 1 99  ? 101.203 118.038 139.368 1.00 418.05 ? 99  GLN A N     1 
ATOM   413  C CA    . GLN A 1 99  ? 100.059 117.458 140.046 1.00 418.05 ? 99  GLN A CA    1 
ATOM   414  C C     . GLN A 1 99  ? 100.346 116.003 140.402 1.00 418.05 ? 99  GLN A C     1 
ATOM   415  O O     . GLN A 1 99  ? 100.863 115.242 139.574 1.00 418.05 ? 99  GLN A O     1 
ATOM   416  C CB    . GLN A 1 99  ? 98.819  117.581 139.148 1.00 418.05 ? 99  GLN A CB    1 
ATOM   417  C CG    . GLN A 1 99  ? 98.505  118.994 138.730 1.00 418.05 ? 99  GLN A CG    1 
ATOM   418  C CD    . GLN A 1 99  ? 98.900  119.369 137.278 1.00 418.05 ? 99  GLN A CD    1 
ATOM   419  O OE1   . GLN A 1 99  ? 98.150  119.124 136.322 1.00 418.05 ? 99  GLN A OE1   1 
ATOM   420  N NE2   . GLN A 1 99  ? 100.094 119.958 137.123 1.00 418.05 ? 99  GLN A NE2   1 
ATOM   421  N N     . ILE A 1 100 ? 100.053 115.635 141.652 1.00 398.91 ? 100 ILE A N     1 
ATOM   422  C CA    . ILE A 1 100 ? 100.169 114.260 142.131 1.00 398.91 ? 100 ILE A CA    1 
ATOM   423  C C     . ILE A 1 100 ? 98.877  113.902 142.842 1.00 398.91 ? 100 ILE A C     1 
ATOM   424  O O     . ILE A 1 100 ? 98.559  114.482 143.888 1.00 398.91 ? 100 ILE A O     1 
ATOM   425  C CB    . ILE A 1 100 ? 101.350 114.049 143.091 1.00 398.91 ? 100 ILE A CB    1 
ATOM   426  C CG1   . ILE A 1 100 ? 102.695 114.086 142.357 1.00 398.91 ? 100 ILE A CG1   1 
ATOM   427  C CG2   . ILE A 1 100 ? 101.155 112.700 143.817 1.00 398.91 ? 100 ILE A CG2   1 
ATOM   428  C CD1   . ILE A 1 100 ? 102.864 112.967 141.344 1.00 398.91 ? 100 ILE A CD1   1 
ATOM   429  N N     . ALA A 1 101 ? 98.135  112.962 142.283 1.00 413.37 ? 101 ALA A N     1 
ATOM   430  C CA    . ALA A 1 101 ? 96.886  112.512 142.877 1.00 413.37 ? 101 ALA A CA    1 
ATOM   431  C C     . ALA A 1 101 ? 97.085  111.175 143.574 1.00 413.37 ? 101 ALA A C     1 
ATOM   432  O O     . ALA A 1 101 ? 97.262  110.148 142.910 1.00 413.37 ? 101 ALA A O     1 
ATOM   433  C CB    . ALA A 1 101 ? 95.802  112.401 141.808 1.00 413.37 ? 101 ALA A CB    1 
ATOM   434  N N     . VAL A 1 102 ? 96.993  111.175 144.904 1.00 518.28 ? 102 VAL A N     1 
ATOM   435  C CA    . VAL A 1 102 ? 97.012  109.948 145.692 1.00 518.28 ? 102 VAL A CA    1 
ATOM   436  C C     . VAL A 1 102 ? 95.572  109.544 146.000 1.00 518.28 ? 102 VAL A C     1 
ATOM   437  O O     . VAL A 1 102 ? 94.728  110.402 146.283 1.00 518.28 ? 102 VAL A O     1 
ATOM   438  C CB    . VAL A 1 102 ? 97.839  110.125 146.987 1.00 518.28 ? 102 VAL A CB    1 
ATOM   439  C CG1   . VAL A 1 102 ? 97.695  108.913 147.917 1.00 518.28 ? 102 VAL A CG1   1 
ATOM   440  C CG2   . VAL A 1 102 ? 99.296  110.385 146.644 1.00 518.28 ? 102 VAL A CG2   1 
ATOM   441  N N     . GLU A 1 103 ? 95.287  108.240 145.918 1.00 496.28 ? 103 GLU A N     1 
ATOM   442  C CA    . GLU A 1 103 ? 93.926  107.746 146.116 1.00 496.28 ? 103 GLU A CA    1 
ATOM   443  C C     . GLU A 1 103 ? 93.346  108.260 147.428 1.00 496.28 ? 103 GLU A C     1 
ATOM   444  O O     . GLU A 1 103 ? 93.995  108.197 148.474 1.00 496.28 ? 103 GLU A O     1 
ATOM   445  C CB    . GLU A 1 103 ? 93.904  106.216 146.099 1.00 496.28 ? 103 GLU A CB    1 
ATOM   446  C CG    . GLU A 1 103 ? 93.522  105.611 144.766 1.00 496.28 ? 103 GLU A CG    1 
ATOM   447  C CD    . GLU A 1 103 ? 93.254  104.124 144.877 1.00 496.28 ? 103 GLU A CD    1 
ATOM   448  O OE1   . GLU A 1 103 ? 92.844  103.678 145.969 1.00 496.28 ? 103 GLU A OE1   1 
ATOM   449  O OE2   . GLU A 1 103 ? 93.446  103.401 143.880 1.00 496.28 ? 103 GLU A OE2   1 
ATOM   450  N N     . ASN A 1 104 ? 92.126  108.790 147.354 1.00 512.52 ? 104 ASN A N     1 
ATOM   451  C CA    . ASN A 1 104 ? 91.307  109.247 148.480 1.00 512.52 ? 104 ASN A CA    1 
ATOM   452  C C     . ASN A 1 104 ? 91.832  110.539 149.095 1.00 512.52 ? 104 ASN A C     1 
ATOM   453  O O     . ASN A 1 104 ? 91.346  110.942 150.161 1.00 512.52 ? 104 ASN A O     1 
ATOM   454  C CB    . ASN A 1 104 ? 91.185  108.180 149.575 1.00 512.52 ? 104 ASN A CB    1 
ATOM   455  C CG    . ASN A 1 104 ? 90.515  106.915 149.077 1.00 512.52 ? 104 ASN A CG    1 
ATOM   456  O OD1   . ASN A 1 104 ? 89.499  106.969 148.382 1.00 512.52 ? 104 ASN A OD1   1 
ATOM   457  N ND2   . ASN A 1 104 ? 91.082  105.768 149.430 1.00 512.52 ? 104 ASN A ND2   1 
ATOM   458  N N     . TYR A 1 105 ? 92.798  111.206 148.469 1.00 538.03 ? 105 TYR A N     1 
ATOM   459  C CA    . TYR A 1 105 ? 93.292  112.472 148.981 1.00 538.03 ? 105 TYR A CA    1 
ATOM   460  C C     . TYR A 1 105 ? 93.136  113.564 147.934 1.00 538.03 ? 105 TYR A C     1 
ATOM   461  O O     . TYR A 1 105 ? 93.159  113.285 146.731 1.00 538.03 ? 105 TYR A O     1 
ATOM   462  C CB    . TYR A 1 105 ? 94.769  112.382 149.386 1.00 538.03 ? 105 TYR A CB    1 
ATOM   463  C CG    . TYR A 1 105 ? 95.034  111.540 150.610 1.00 538.03 ? 105 TYR A CG    1 
ATOM   464  C CD1   . TYR A 1 105 ? 95.029  112.105 151.877 1.00 538.03 ? 105 TYR A CD1   1 
ATOM   465  C CD2   . TYR A 1 105 ? 95.300  110.183 150.498 1.00 538.03 ? 105 TYR A CD2   1 
ATOM   466  C CE1   . TYR A 1 105 ? 95.276  111.340 153.001 1.00 538.03 ? 105 TYR A CE1   1 
ATOM   467  C CE2   . TYR A 1 105 ? 95.547  109.410 151.615 1.00 538.03 ? 105 TYR A CE2   1 
ATOM   468  C CZ    . TYR A 1 105 ? 95.534  109.993 152.863 1.00 538.03 ? 105 TYR A CZ    1 
ATOM   469  O OH    . TYR A 1 105 ? 95.780  109.224 153.977 1.00 538.03 ? 105 TYR A OH    1 
ATOM   470  N N     . PRO A 1 106 ? 92.958  114.814 148.357 1.00 584.44 ? 106 PRO A N     1 
ATOM   471  C CA    . PRO A 1 106 ? 93.068  115.924 147.408 1.00 584.44 ? 106 PRO A CA    1 
ATOM   472  C C     . PRO A 1 106 ? 94.436  115.935 146.744 1.00 584.44 ? 106 PRO A C     1 
ATOM   473  O O     . PRO A 1 106 ? 95.440  115.517 147.328 1.00 584.44 ? 106 PRO A O     1 
ATOM   474  C CB    . PRO A 1 106 ? 92.855  117.170 148.279 1.00 584.44 ? 106 PRO A CB    1 
ATOM   475  C CG    . PRO A 1 106 ? 92.608  116.685 149.675 1.00 584.44 ? 106 PRO A CG    1 
ATOM   476  C CD    . PRO A 1 106 ? 92.341  115.222 149.628 1.00 584.44 ? 106 PRO A CD    1 
ATOM   477  N N     . VAL A 1 107 ? 94.467  116.422 145.506 1.00 508.37 ? 107 VAL A N     1 
ATOM   478  C CA    . VAL A 1 107 ? 95.686  116.376 144.707 1.00 508.37 ? 107 VAL A CA    1 
ATOM   479  C C     . VAL A 1 107 ? 96.726  117.325 145.290 1.00 508.37 ? 107 VAL A C     1 
ATOM   480  O O     . VAL A 1 107 ? 96.422  118.469 145.646 1.00 508.37 ? 107 VAL A O     1 
ATOM   481  C CB    . VAL A 1 107 ? 95.382  116.723 143.243 1.00 508.37 ? 107 VAL A CB    1 
ATOM   482  C CG1   . VAL A 1 107 ? 96.619  116.520 142.383 1.00 508.37 ? 107 VAL A CG1   1 
ATOM   483  C CG2   . VAL A 1 107 ? 94.221  115.881 142.733 1.00 508.37 ? 107 VAL A CG2   1 
ATOM   484  N N     . ILE A 1 108 ? 97.963  116.852 145.387 1.00 472.22 ? 108 ILE A N     1 
ATOM   485  C CA    . ILE A 1 108 ? 99.066  117.693 145.833 1.00 472.22 ? 108 ILE A CA    1 
ATOM   486  C C     . ILE A 1 108 ? 99.606  118.420 144.611 1.00 472.22 ? 108 ILE A C     1 
ATOM   487  O O     . ILE A 1 108 ? 100.069 117.787 143.654 1.00 472.22 ? 108 ILE A O     1 
ATOM   488  C CB    . ILE A 1 108 ? 100.160 116.863 146.516 1.00 472.22 ? 108 ILE A CB    1 
ATOM   489  C CG1   . ILE A 1 108 ? 99.600  116.158 147.752 1.00 472.22 ? 108 ILE A CG1   1 
ATOM   490  C CG2   . ILE A 1 108 ? 101.329 117.748 146.898 1.00 472.22 ? 108 ILE A CG2   1 
ATOM   491  C CD1   . ILE A 1 108 ? 100.497 115.067 148.294 1.00 472.22 ? 108 ILE A CD1   1 
ATOM   492  N N     . ILE A 1 109 ? 99.483  119.742 144.604 1.00 445.85 ? 109 ILE A N     1 
ATOM   493  C CA    . ILE A 1 109 ? 99.888  120.545 143.459 1.00 445.85 ? 109 ILE A CA    1 
ATOM   494  C C     . ILE A 1 109 ? 101.076 121.409 143.855 1.00 445.85 ? 109 ILE A C     1 
ATOM   495  O O     . ILE A 1 109 ? 100.965 122.293 144.713 1.00 445.85 ? 109 ILE A O     1 
ATOM   496  C CB    . ILE A 1 109 ? 98.734  121.403 142.929 1.00 445.85 ? 109 ILE A CB    1 
ATOM   497  C CG1   . ILE A 1 109 ? 97.654  120.510 142.314 1.00 445.85 ? 109 ILE A CG1   1 
ATOM   498  C CG2   . ILE A 1 109 ? 99.247  122.399 141.903 1.00 445.85 ? 109 ILE A CG2   1 
ATOM   499  C CD1   . ILE A 1 109 ? 96.457  121.266 141.783 1.00 445.85 ? 109 ILE A CD1   1 
ATOM   500  N N     . TYR A 1 110 ? 102.217 121.146 143.230 1.00 402.12 ? 110 TYR A N     1 
ATOM   501  C CA    . TYR A 1 110 ? 103.425 121.932 143.418 1.00 402.12 ? 110 TYR A CA    1 
ATOM   502  C C     . TYR A 1 110 ? 103.372 123.090 142.432 1.00 402.12 ? 110 TYR A C     1 
ATOM   503  O O     . TYR A 1 110 ? 103.362 122.876 141.211 1.00 402.12 ? 110 TYR A O     1 
ATOM   504  C CB    . TYR A 1 110 ? 104.680 121.086 143.221 1.00 402.12 ? 110 TYR A CB    1 
ATOM   505  C CG    . TYR A 1 110 ? 104.916 120.076 144.318 1.00 402.12 ? 110 TYR A CG    1 
ATOM   506  C CD1   . TYR A 1 110 ? 104.280 118.844 144.295 1.00 402.12 ? 110 TYR A CD1   1 
ATOM   507  C CD2   . TYR A 1 110 ? 105.799 120.338 145.361 1.00 402.12 ? 110 TYR A CD2   1 
ATOM   508  C CE1   . TYR A 1 110 ? 104.492 117.914 145.287 1.00 402.12 ? 110 TYR A CE1   1 
ATOM   509  C CE2   . TYR A 1 110 ? 106.023 119.407 146.360 1.00 402.12 ? 110 TYR A CE2   1 
ATOM   510  C CZ    . TYR A 1 110 ? 105.363 118.195 146.315 1.00 402.12 ? 110 TYR A CZ    1 
ATOM   511  O OH    . TYR A 1 110 ? 105.568 117.254 147.298 1.00 402.12 ? 110 TYR A OH    1 
ATOM   512  N N     . ASP A 1 111 ? 103.260 124.303 142.965 1.00 437.82 ? 111 ASP A N     1 
ATOM   513  C CA    . ASP A 1 111 ? 103.277 125.541 142.194 1.00 437.82 ? 111 ASP A CA    1 
ATOM   514  C C     . ASP A 1 111 ? 104.736 125.869 141.916 1.00 437.82 ? 111 ASP A C     1 
ATOM   515  O O     . ASP A 1 111 ? 105.422 126.488 142.729 1.00 437.82 ? 111 ASP A O     1 
ATOM   516  C CB    . ASP A 1 111 ? 102.569 126.657 142.954 1.00 437.82 ? 111 ASP A CB    1 
ATOM   517  C CG    . ASP A 1 111 ? 102.500 127.964 142.175 1.00 437.82 ? 111 ASP A CG    1 
ATOM   518  O OD1   . ASP A 1 111 ? 103.116 128.073 141.093 1.00 437.82 ? 111 ASP A OD1   1 
ATOM   519  O OD2   . ASP A 1 111 ? 101.811 128.890 142.651 1.00 437.82 ? 111 ASP A OD2   1 
ATOM   520  N N     . MET A 1 112 ? 105.209 125.466 140.735 1.00 419.74 ? 112 MET A N     1 
ATOM   521  C CA    . MET A 1 112 ? 106.640 125.525 140.449 1.00 419.74 ? 112 MET A CA    1 
ATOM   522  C C     . MET A 1 112 ? 107.112 126.956 140.256 1.00 419.74 ? 112 MET A C     1 
ATOM   523  O O     . MET A 1 112 ? 108.290 127.255 140.488 1.00 419.74 ? 112 MET A O     1 
ATOM   524  C CB    . MET A 1 112 ? 106.985 124.676 139.228 1.00 419.74 ? 112 MET A CB    1 
ATOM   525  C CG    . MET A 1 112 ? 106.625 123.209 139.372 1.00 419.74 ? 112 MET A CG    1 
ATOM   526  S SD    . MET A 1 112 ? 107.544 122.452 140.730 1.00 419.74 ? 112 MET A SD    1 
ATOM   527  C CE    . MET A 1 112 ? 109.185 122.326 140.022 1.00 419.74 ? 112 MET A CE    1 
ATOM   528  N N     . PHE A 1 113 ? 106.230 127.853 139.814 1.00 417.82 ? 113 PHE A N     1 
ATOM   529  C CA    . PHE A 1 113 ? 106.647 129.242 139.686 1.00 417.82 ? 113 PHE A CA    1 
ATOM   530  C C     . PHE A 1 113 ? 106.761 129.910 141.047 1.00 417.82 ? 113 PHE A C     1 
ATOM   531  O O     . PHE A 1 113 ? 107.283 131.026 141.136 1.00 417.82 ? 113 PHE A O     1 
ATOM   532  C CB    . PHE A 1 113 ? 105.683 130.020 138.787 1.00 417.82 ? 113 PHE A CB    1 
ATOM   533  C CG    . PHE A 1 113 ? 105.926 129.817 137.317 1.00 417.82 ? 113 PHE A CG    1 
ATOM   534  C CD1   . PHE A 1 113 ? 106.684 128.753 136.859 1.00 417.82 ? 113 PHE A CD1   1 
ATOM   535  C CD2   . PHE A 1 113 ? 105.415 130.715 136.394 1.00 417.82 ? 113 PHE A CD2   1 
ATOM   536  C CE1   . PHE A 1 113 ? 106.913 128.578 135.506 1.00 417.82 ? 113 PHE A CE1   1 
ATOM   537  C CE2   . PHE A 1 113 ? 105.638 130.544 135.042 1.00 417.82 ? 113 PHE A CE2   1 
ATOM   538  C CZ    . PHE A 1 113 ? 106.389 129.475 134.597 1.00 417.82 ? 113 PHE A CZ    1 
ATOM   539  N N     . ASN A 1 114 ? 106.297 129.244 142.108 1.00 497.67 ? 114 ASN A N     1 
ATOM   540  C CA    . ASN A 1 114 ? 106.360 129.778 143.462 1.00 497.67 ? 114 ASN A CA    1 
ATOM   541  C C     . ASN A 1 114 ? 106.975 128.768 144.425 1.00 497.67 ? 114 ASN A C     1 
ATOM   542  O O     . ASN A 1 114 ? 106.523 128.642 145.568 1.00 497.67 ? 114 ASN A O     1 
ATOM   543  C CB    . ASN A 1 114 ? 104.965 130.191 143.941 1.00 497.67 ? 114 ASN A CB    1 
ATOM   544  C CG    . ASN A 1 114 ? 104.395 131.348 143.146 1.00 497.67 ? 114 ASN A CG    1 
ATOM   545  O OD1   . ASN A 1 114 ? 104.766 132.503 143.357 1.00 497.67 ? 114 ASN A OD1   1 
ATOM   546  N ND2   . ASN A 1 114 ? 103.480 131.046 142.233 1.00 497.67 ? 114 ASN A ND2   1 
ATOM   547  N N     . ILE A 1 115 ? 108.001 128.051 143.978 1.00 491.47 ? 115 ILE A N     1 
ATOM   548  C CA    . ILE A 1 115 ? 108.781 127.132 144.802 1.00 491.47 ? 115 ILE A CA    1 
ATOM   549  C C     . ILE A 1 115 ? 110.246 127.389 144.482 1.00 491.47 ? 115 ILE A C     1 
ATOM   550  O O     . ILE A 1 115 ? 110.638 127.400 143.310 1.00 491.47 ? 115 ILE A O     1 
ATOM   551  C CB    . ILE A 1 115 ? 108.400 125.666 144.560 1.00 491.47 ? 115 ILE A CB    1 
ATOM   552  C CG1   . ILE A 1 115 ? 107.023 125.365 145.156 1.00 491.47 ? 115 ILE A CG1   1 
ATOM   553  C CG2   . ILE A 1 115 ? 109.450 124.734 145.148 1.00 491.47 ? 115 ILE A CG2   1 
ATOM   554  C CD1   . ILE A 1 115 ? 106.478 124.006 144.779 1.00 491.47 ? 115 ILE A CD1   1 
ATOM   555  N N     . ASN A 1 116 ? 111.064 127.589 145.515 1.00 538.26 ? 116 ASN A N     1 
ATOM   556  C CA    . ASN A 1 116 ? 112.488 127.825 145.318 1.00 538.26 ? 116 ASN A CA    1 
ATOM   557  C C     . ASN A 1 116 ? 113.381 127.030 146.254 1.00 538.26 ? 116 ASN A C     1 
ATOM   558  O O     . ASN A 1 116 ? 114.601 127.043 146.074 1.00 538.26 ? 116 ASN A O     1 
ATOM   559  C CB    . ASN A 1 116 ? 112.809 129.317 145.483 1.00 538.26 ? 116 ASN A CB    1 
ATOM   560  C CG    . ASN A 1 116 ? 112.002 130.196 144.549 1.00 538.26 ? 116 ASN A CG    1 
ATOM   561  O OD1   . ASN A 1 116 ? 111.869 129.905 143.361 1.00 538.26 ? 116 ASN A OD1   1 
ATOM   562  N ND2   . ASN A 1 116 ? 111.456 131.282 145.085 1.00 538.26 ? 116 ASN A ND2   1 
ATOM   563  N N     . LYS A 1 117 ? 112.818 126.340 147.242 1.00 455.86 ? 117 LYS A N     1 
ATOM   564  C CA    . LYS A 1 117 ? 113.611 125.476 148.109 1.00 455.86 ? 117 LYS A CA    1 
ATOM   565  C C     . LYS A 1 117 ? 113.607 124.068 147.526 1.00 455.86 ? 117 LYS A C     1 
ATOM   566  O O     . LYS A 1 117 ? 112.540 123.504 147.265 1.00 455.86 ? 117 LYS A O     1 
ATOM   567  C CB    . LYS A 1 117 ? 113.040 125.488 149.525 1.00 455.86 ? 117 LYS A CB    1 
ATOM   568  C CG    . LYS A 1 117 ? 112.984 126.864 150.163 1.00 455.86 ? 117 LYS A CG    1 
ATOM   569  C CD    . LYS A 1 117 ? 112.357 126.799 151.547 1.00 455.86 ? 117 LYS A CD    1 
ATOM   570  C CE    . LYS A 1 117 ? 112.398 128.150 152.237 1.00 455.86 ? 117 LYS A CE    1 
ATOM   571  N NZ    . LYS A 1 117 ? 111.785 128.095 153.593 1.00 455.86 ? 117 LYS A NZ    1 
ATOM   572  N N     . LYS A 1 118 ? 114.799 123.501 147.311 1.00 440.73 ? 118 LYS A N     1 
ATOM   573  C CA    . LYS A 1 118 ? 114.876 122.161 146.735 1.00 440.73 ? 118 LYS A CA    1 
ATOM   574  C C     . LYS A 1 118 ? 114.263 121.114 147.656 1.00 440.73 ? 118 LYS A C     1 
ATOM   575  O O     . LYS A 1 118 ? 113.700 120.120 147.175 1.00 440.73 ? 118 LYS A O     1 
ATOM   576  C CB    . LYS A 1 118 ? 116.328 121.808 146.417 1.00 440.73 ? 118 LYS A CB    1 
ATOM   577  C CG    . LYS A 1 118 ? 117.072 122.877 145.631 1.00 440.73 ? 118 LYS A CG    1 
ATOM   578  C CD    . LYS A 1 118 ? 118.471 122.412 145.252 1.00 440.73 ? 118 LYS A CD    1 
ATOM   579  C CE    . LYS A 1 118 ? 119.225 123.492 144.494 1.00 440.73 ? 118 LYS A CE    1 
ATOM   580  N NZ    . LYS A 1 118 ? 120.593 123.049 144.106 1.00 440.73 ? 118 LYS A NZ    1 
ATOM   581  N N     . ASP A 1 119 ? 114.298 121.352 148.972 1.00 464.85 ? 119 ASP A N     1 
ATOM   582  C CA    . ASP A 1 119 ? 113.769 120.377 149.919 1.00 464.85 ? 119 ASP A CA    1 
ATOM   583  C C     . ASP A 1 119 ? 112.304 120.082 149.657 1.00 464.85 ? 119 ASP A C     1 
ATOM   584  O O     . ASP A 1 119 ? 111.867 118.942 149.865 1.00 464.85 ? 119 ASP A O     1 
ATOM   585  C CB    . ASP A 1 119 ? 113.959 120.868 151.357 1.00 464.85 ? 119 ASP A CB    1 
ATOM   586  C CG    . ASP A 1 119 ? 114.111 122.372 151.447 1.00 464.85 ? 119 ASP A CG    1 
ATOM   587  O OD1   . ASP A 1 119 ? 114.648 122.975 150.495 1.00 464.85 ? 119 ASP A OD1   1 
ATOM   588  O OD2   . ASP A 1 119 ? 113.690 122.953 152.469 1.00 464.85 ? 119 ASP A OD2   1 
ATOM   589  N N     . ILE A 1 120 ? 111.563 121.057 149.127 1.00 389.67 ? 120 ILE A N     1 
ATOM   590  C CA    . ILE A 1 120 ? 110.133 120.888 148.950 1.00 389.67 ? 120 ILE A CA    1 
ATOM   591  C C     . ILE A 1 120 ? 109.879 119.778 147.951 1.00 389.67 ? 120 ILE A C     1 
ATOM   592  O O     . ILE A 1 120 ? 108.884 119.052 148.063 1.00 389.67 ? 120 ILE A O     1 
ATOM   593  C CB    . ILE A 1 120 ? 109.494 122.217 148.502 1.00 389.67 ? 120 ILE A CB    1 
ATOM   594  C CG1   . ILE A 1 120 ? 109.703 123.296 149.567 1.00 389.67 ? 120 ILE A CG1   1 
ATOM   595  C CG2   . ILE A 1 120 ? 108.027 122.038 148.170 1.00 389.67 ? 120 ILE A CG2   1 
ATOM   596  C CD1   . ILE A 1 120 ? 109.166 124.649 149.175 1.00 389.67 ? 120 ILE A CD1   1 
ATOM   597  N N     . LEU A 1 121 ? 110.776 119.613 146.983 1.00 411.24 ? 121 LEU A N     1 
ATOM   598  C CA    . LEU A 1 121 ? 110.595 118.622 145.940 1.00 411.24 ? 121 LEU A CA    1 
ATOM   599  C C     . LEU A 1 121 ? 111.276 117.306 146.284 1.00 411.24 ? 121 LEU A C     1 
ATOM   600  O O     . LEU A 1 121 ? 111.160 116.346 145.515 1.00 411.24 ? 121 LEU A O     1 
ATOM   601  C CB    . LEU A 1 121 ? 111.128 119.155 144.607 1.00 411.24 ? 121 LEU A CB    1 
ATOM   602  C CG    . LEU A 1 121 ? 110.576 120.516 144.176 1.00 411.24 ? 121 LEU A CG    1 
ATOM   603  C CD1   . LEU A 1 121 ? 111.274 121.010 142.918 1.00 411.24 ? 121 LEU A CD1   1 
ATOM   604  C CD2   . LEU A 1 121 ? 109.071 120.453 143.970 1.00 411.24 ? 121 LEU A CD2   1 
ATOM   605  N N     . ASP A 1 122 ? 111.933 117.224 147.450 1.00 442.44 ? 122 ASP A N     1 
ATOM   606  C CA    . ASP A 1 122 ? 112.668 116.010 147.797 1.00 442.44 ? 122 ASP A CA    1 
ATOM   607  C C     . ASP A 1 122 ? 111.749 114.797 147.800 1.00 442.44 ? 122 ASP A C     1 
ATOM   608  O O     . ASP A 1 122 ? 111.962 113.844 147.041 1.00 442.44 ? 122 ASP A O     1 
ATOM   609  C CB    . ASP A 1 122 ? 113.347 116.178 149.156 1.00 442.44 ? 122 ASP A CB    1 
ATOM   610  C CG    . ASP A 1 122 ? 114.570 117.070 149.089 1.00 442.44 ? 122 ASP A CG    1 
ATOM   611  O OD1   . ASP A 1 122 ? 114.837 117.635 148.007 1.00 442.44 ? 122 ASP A OD1   1 
ATOM   612  O OD2   . ASP A 1 122 ? 115.265 117.208 150.118 1.00 442.44 ? 122 ASP A OD2   1 
ATOM   613  N N     . GLY A 1 123 ? 110.706 114.823 148.635 1.00 411.59 ? 123 GLY A N     1 
ATOM   614  C CA    . GLY A 1 123 ? 109.769 113.713 148.649 1.00 411.59 ? 123 GLY A CA    1 
ATOM   615  C C     . GLY A 1 123 ? 109.161 113.485 147.281 1.00 411.59 ? 123 GLY A C     1 
ATOM   616  O O     . GLY A 1 123 ? 108.985 112.339 146.851 1.00 411.59 ? 123 GLY A O     1 
ATOM   617  N N     . LEU A 1 124 ? 109.026 114.565 146.504 1.00 405.95 ? 124 LEU A N     1 
ATOM   618  C CA    . LEU A 1 124 ? 108.530 114.436 145.142 1.00 405.95 ? 124 LEU A CA    1 
ATOM   619  C C     . LEU A 1 124 ? 109.515 113.617 144.335 1.00 405.95 ? 124 LEU A C     1 
ATOM   620  O O     . LEU A 1 124 ? 109.142 112.623 143.699 1.00 405.95 ? 124 LEU A O     1 
ATOM   621  C CB    . LEU A 1 124 ? 108.313 115.815 144.520 1.00 405.95 ? 124 LEU A CB    1 
ATOM   622  C CG    . LEU A 1 124 ? 107.938 115.825 143.038 1.00 405.95 ? 124 LEU A CG    1 
ATOM   623  C CD1   . LEU A 1 124 ? 106.606 115.125 142.820 1.00 405.95 ? 124 LEU A CD1   1 
ATOM   624  C CD2   . LEU A 1 124 ? 107.891 117.248 142.509 1.00 405.95 ? 124 LEU A CD2   1 
ATOM   625  N N     . ARG A 1 125 ? 110.788 114.018 144.359 1.00 401.82 ? 125 ARG A N     1 
ATOM   626  C CA    . ARG A 1 125 ? 111.789 113.283 143.607 1.00 401.82 ? 125 ARG A CA    1 
ATOM   627  C C     . ARG A 1 125 ? 111.770 111.822 144.030 1.00 401.82 ? 125 ARG A C     1 
ATOM   628  O O     . ARG A 1 125 ? 111.866 110.923 143.184 1.00 401.82 ? 125 ARG A O     1 
ATOM   629  C CB    . ARG A 1 125 ? 113.175 113.889 143.831 1.00 401.82 ? 125 ARG A CB    1 
ATOM   630  C CG    . ARG A 1 125 ? 113.336 115.307 143.315 1.00 401.82 ? 125 ARG A CG    1 
ATOM   631  C CD    . ARG A 1 125 ? 114.771 115.785 143.481 1.00 401.82 ? 125 ARG A CD    1 
ATOM   632  N NE    . ARG A 1 125 ? 114.928 117.190 143.128 1.00 401.82 ? 125 ARG A NE    1 
ATOM   633  C CZ    . ARG A 1 125 ? 115.101 117.635 141.891 1.00 401.82 ? 125 ARG A CZ    1 
ATOM   634  N NH1   . ARG A 1 125 ? 115.199 118.945 141.680 1.00 401.82 ? 125 ARG A NH1   1 
ATOM   635  N NH2   . ARG A 1 125 ? 115.193 116.806 140.864 1.00 401.82 ? 125 ARG A NH2   1 
ATOM   636  N N     . LYS A 1 126 ? 111.498 111.565 145.320 1.00 380.42 ? 126 LYS A N     1 
ATOM   637  C CA    . LYS A 1 126 ? 111.498 110.183 145.784 1.00 380.42 ? 126 LYS A CA    1 
ATOM   638  C C     . LYS A 1 126 ? 110.395 109.416 145.084 1.00 380.42 ? 126 LYS A C     1 
ATOM   639  O O     . LYS A 1 126 ? 110.644 108.350 144.504 1.00 380.42 ? 126 LYS A O     1 
ATOM   640  C CB    . LYS A 1 126 ? 111.322 110.137 147.300 1.00 380.42 ? 126 LYS A CB    1 
ATOM   641  C CG    . LYS A 1 126 ? 112.464 110.772 148.076 1.00 380.42 ? 126 LYS A CG    1 
ATOM   642  C CD    . LYS A 1 126 ? 112.140 110.879 149.559 1.00 380.42 ? 126 LYS A CD    1 
ATOM   643  C CE    . LYS A 1 126 ? 113.235 111.618 150.311 1.00 380.42 ? 126 LYS A CE    1 
ATOM   644  N NZ    . LYS A 1 126 ? 112.874 111.847 151.737 1.00 380.42 ? 126 LYS A NZ    1 
ATOM   645  N N     . VAL A 1 127 ? 109.199 110.005 145.022 1.00 384.91 ? 127 VAL A N     1 
ATOM   646  C CA    . VAL A 1 127 ? 108.105 109.355 144.314 1.00 384.91 ? 127 VAL A CA    1 
ATOM   647  C C     . VAL A 1 127 ? 108.555 109.090 142.892 1.00 384.91 ? 127 VAL A C     1 
ATOM   648  O O     . VAL A 1 127 ? 108.387 107.986 142.359 1.00 384.91 ? 127 VAL A O     1 
ATOM   649  C CB    . VAL A 1 127 ? 106.831 110.216 144.365 1.00 384.91 ? 127 VAL A CB    1 
ATOM   650  C CG1   . VAL A 1 127 ? 105.773 109.652 143.426 1.00 384.91 ? 127 VAL A CG1   1 
ATOM   651  C CG2   . VAL A 1 127 ? 106.304 110.292 145.785 1.00 384.91 ? 127 VAL A CG2   1 
ATOM   652  N N     . LEU A 1 128 ? 109.122 110.114 142.249 1.00 377.51 ? 128 LEU A N     1 
ATOM   653  C CA    . LEU A 1 128 ? 109.563 109.971 140.873 1.00 377.51 ? 128 LEU A CA    1 
ATOM   654  C C     . LEU A 1 128 ? 110.608 108.872 140.768 1.00 377.51 ? 128 LEU A C     1 
ATOM   655  O O     . LEU A 1 128 ? 110.558 108.049 139.847 1.00 377.51 ? 128 LEU A O     1 
ATOM   656  C CB    . LEU A 1 128 ? 110.110 111.298 140.353 1.00 377.51 ? 128 LEU A CB    1 
ATOM   657  C CG    . LEU A 1 128 ? 109.102 112.447 140.404 1.00 377.51 ? 128 LEU A CG    1 
ATOM   658  C CD1   . LEU A 1 128 ? 109.761 113.766 140.051 1.00 377.51 ? 128 LEU A CD1   1 
ATOM   659  C CD2   . LEU A 1 128 ? 107.926 112.163 139.483 1.00 377.51 ? 128 LEU A CD2   1 
ATOM   660  N N     . GLU A 1 129 ? 111.574 108.854 141.685 1.00 394.08 ? 129 GLU A N     1 
ATOM   661  C CA    . GLU A 1 129 ? 112.640 107.869 141.612 1.00 394.08 ? 129 GLU A CA    1 
ATOM   662  C C     . GLU A 1 129 ? 112.176 106.468 141.990 1.00 394.08 ? 129 GLU A C     1 
ATOM   663  O O     . GLU A 1 129 ? 112.767 105.492 141.517 1.00 394.08 ? 129 GLU A O     1 
ATOM   664  C CB    . GLU A 1 129 ? 113.804 108.295 142.514 1.00 394.08 ? 129 GLU A CB    1 
ATOM   665  C CG    . GLU A 1 129 ? 114.609 109.453 141.944 1.00 394.08 ? 129 GLU A CG    1 
ATOM   666  C CD    . GLU A 1 129 ? 115.803 109.827 142.801 1.00 394.08 ? 129 GLU A CD    1 
ATOM   667  O OE1   . GLU A 1 129 ? 116.463 108.912 143.339 1.00 394.08 ? 129 GLU A OE1   1 
ATOM   668  O OE2   . GLU A 1 129 ? 116.073 111.037 142.944 1.00 394.08 ? 129 GLU A OE2   1 
ATOM   669  N N     . ASN A 1 130 ? 111.149 106.352 142.833 1.00 342.23 ? 130 ASN A N     1 
ATOM   670  C CA    . ASN A 1 130 ? 110.738 105.053 143.354 1.00 342.23 ? 130 ASN A CA    1 
ATOM   671  C C     . ASN A 1 130 ? 110.282 104.142 142.219 1.00 342.23 ? 130 ASN A C     1 
ATOM   672  O O     . ASN A 1 130 ? 109.204 104.337 141.649 1.00 342.23 ? 130 ASN A O     1 
ATOM   673  C CB    . ASN A 1 130 ? 109.624 105.228 144.385 1.00 342.23 ? 130 ASN A CB    1 
ATOM   674  C CG    . ASN A 1 130 ? 109.316 103.944 145.142 1.00 342.23 ? 130 ASN A CG    1 
ATOM   675  O OD1   . ASN A 1 130 ? 109.640 102.845 144.691 1.00 342.23 ? 130 ASN A OD1   1 
ATOM   676  N ND2   . ASN A 1 130 ? 108.704 104.082 146.310 1.00 342.23 ? 130 ASN A ND2   1 
ATOM   677  N N     . LYS A 1 131 ? 111.108 103.146 141.893 1.00 337.54 ? 131 LYS A N     1 
ATOM   678  C CA    . LYS A 1 131 ? 110.798 102.198 140.830 1.00 337.54 ? 131 LYS A CA    1 
ATOM   679  C C     . LYS A 1 131 ? 109.602 101.309 141.157 1.00 337.54 ? 131 LYS A C     1 
ATOM   680  O O     . LYS A 1 131 ? 109.140 100.575 140.275 1.00 337.54 ? 131 LYS A O     1 
ATOM   681  C CB    . LYS A 1 131 ? 112.020 101.332 140.528 1.00 337.54 ? 131 LYS A CB    1 
ATOM   682  C CG    . LYS A 1 131 ? 113.257 102.130 140.162 1.00 337.54 ? 131 LYS A CG    1 
ATOM   683  C CD    . LYS A 1 131 ? 114.392 101.222 139.731 1.00 337.54 ? 131 LYS A CD    1 
ATOM   684  C CE    . LYS A 1 131 ? 115.582 102.026 139.232 1.00 337.54 ? 131 LYS A CE    1 
ATOM   685  N NZ    . LYS A 1 131 ? 116.639 101.153 138.653 1.00 337.54 ? 131 LYS A NZ    1 
ATOM   686  N N     . ASN A 1 132 ? 109.089 101.365 142.386 1.00 332.89 ? 132 ASN A N     1 
ATOM   687  C CA    . ASN A 1 132 ? 107.968 100.537 142.814 1.00 332.89 ? 132 ASN A CA    1 
ATOM   688  C C     . ASN A 1 132 ? 106.646 101.285 142.870 1.00 332.89 ? 132 ASN A C     1 
ATOM   689  O O     . ASN A 1 132 ? 105.651 100.711 143.326 1.00 332.89 ? 132 ASN A O     1 
ATOM   690  C CB    . ASN A 1 132 ? 108.259 99.931  144.194 1.00 332.89 ? 132 ASN A CB    1 
ATOM   691  C CG    . ASN A 1 132 ? 109.484 99.040  144.194 1.00 332.89 ? 132 ASN A CG    1 
ATOM   692  O OD1   . ASN A 1 132 ? 109.838 98.449  143.175 1.00 332.89 ? 132 ASN A OD1   1 
ATOM   693  N ND2   . ASN A 1 132 ? 110.145 98.948  145.341 1.00 332.89 ? 132 ASN A ND2   1 
ATOM   694  N N     . ILE A 1 133 ? 106.604 102.539 142.428 1.00 325.34 ? 133 ILE A N     1 
ATOM   695  C CA    . ILE A 1 133 ? 105.363 103.297 142.326 1.00 325.34 ? 133 ILE A CA    1 
ATOM   696  C C     . ILE A 1 133 ? 105.086 103.584 140.860 1.00 325.34 ? 133 ILE A C     1 
ATOM   697  O O     . ILE A 1 133 ? 105.888 104.238 140.181 1.00 325.34 ? 133 ILE A O     1 
ATOM   698  C CB    . ILE A 1 133 ? 105.424 104.604 143.133 1.00 325.34 ? 133 ILE A CB    1 
ATOM   699  C CG1   . ILE A 1 133 ? 105.696 104.313 144.609 1.00 325.34 ? 133 ILE A CG1   1 
ATOM   700  C CG2   . ILE A 1 133 ? 104.127 105.377 142.986 1.00 325.34 ? 133 ILE A CG2   1 
ATOM   701  C CD1   . ILE A 1 133 ? 105.954 105.554 145.435 1.00 325.34 ? 133 ILE A CD1   1 
ATOM   702  N N     . ILE A 1 134 ? 103.948 103.097 140.378 1.00 334.28 ? 134 ILE A N     1 
ATOM   703  C CA    . ILE A 1 134 ? 103.491 103.360 139.018 1.00 334.28 ? 134 ILE A CA    1 
ATOM   704  C C     . ILE A 1 134 ? 103.030 104.812 138.945 1.00 334.28 ? 134 ILE A C     1 
ATOM   705  O O     . ILE A 1 134 ? 102.214 105.253 139.761 1.00 334.28 ? 134 ILE A O     1 
ATOM   706  C CB    . ILE A 1 134 ? 102.368 102.393 138.621 1.00 334.28 ? 134 ILE A CB    1 
ATOM   707  C CG1   . ILE A 1 134 ? 102.877 100.951 138.703 1.00 334.28 ? 134 ILE A CG1   1 
ATOM   708  C CG2   . ILE A 1 134 ? 101.857 102.708 137.221 1.00 334.28 ? 134 ILE A CG2   1 
ATOM   709  C CD1   . ILE A 1 134 ? 101.800 99.905  138.569 1.00 334.28 ? 134 ILE A CD1   1 
ATOM   710  N N     . LYS A 1 135 ? 103.538 105.555 137.961 1.00 387.78 ? 135 LYS A N     1 
ATOM   711  C CA    . LYS A 1 135 ? 103.021 106.889 137.669 1.00 387.78 ? 135 LYS A CA    1 
ATOM   712  C C     . LYS A 1 135 ? 102.030 106.803 136.513 1.00 387.78 ? 135 LYS A C     1 
ATOM   713  O O     . LYS A 1 135 ? 102.408 106.494 135.378 1.00 387.78 ? 135 LYS A O     1 
ATOM   714  C CB    . LYS A 1 135 ? 104.156 107.851 137.317 1.00 387.78 ? 135 LYS A CB    1 
ATOM   715  C CG    . LYS A 1 135 ? 105.175 108.139 138.410 1.00 387.78 ? 135 LYS A CG    1 
ATOM   716  C CD    . LYS A 1 135 ? 106.334 107.164 138.370 1.00 387.78 ? 135 LYS A CD    1 
ATOM   717  C CE    . LYS A 1 135 ? 107.598 107.798 138.884 1.00 387.78 ? 135 LYS A CE    1 
ATOM   718  N NZ    . LYS A 1 135 ? 108.779 106.892 138.773 1.00 387.78 ? 135 LYS A NZ    1 
ATOM   719  N N     . ILE A 1 136 ? 100.765 107.074 136.808 1.00 400.24 ? 136 ILE A N     1 
ATOM   720  C CA    . ILE A 1 136 ? 99.706  107.124 135.808 1.00 400.24 ? 136 ILE A CA    1 
ATOM   721  C C     . ILE A 1 136 ? 99.751  108.514 135.181 1.00 400.24 ? 136 ILE A C     1 
ATOM   722  O O     . ILE A 1 136 ? 99.650  109.517 135.893 1.00 400.24 ? 136 ILE A O     1 
ATOM   723  C CB    . ILE A 1 136 ? 98.343  106.853 136.455 1.00 400.24 ? 136 ILE A CB    1 
ATOM   724  C CG1   . ILE A 1 136 ? 98.456  105.656 137.397 1.00 400.24 ? 136 ILE A CG1   1 
ATOM   725  C CG2   . ILE A 1 136 ? 97.334  106.523 135.384 1.00 400.24 ? 136 ILE A CG2   1 
ATOM   726  C CD1   . ILE A 1 136 ? 97.301  105.524 138.354 1.00 400.24 ? 136 ILE A CD1   1 
ATOM   727  N N     . ILE A 1 137 ? 99.898  108.590 133.857 1.00 462.10 ? 137 ILE A N     1 
ATOM   728  C CA    . ILE A 1 137 ? 100.035 109.878 133.183 1.00 462.10 ? 137 ILE A CA    1 
ATOM   729  C C     . ILE A 1 137 ? 99.155  109.926 131.940 1.00 462.10 ? 137 ILE A C     1 
ATOM   730  O O     . ILE A 1 137 ? 98.901  108.899 131.301 1.00 462.10 ? 137 ILE A O     1 
ATOM   731  C CB    . ILE A 1 137 ? 101.511 110.160 132.810 1.00 462.10 ? 137 ILE A CB    1 
ATOM   732  C CG1   . ILE A 1 137 ? 102.418 110.044 134.037 1.00 462.10 ? 137 ILE A CG1   1 
ATOM   733  C CG2   . ILE A 1 137 ? 101.676 111.545 132.204 1.00 462.10 ? 137 ILE A CG2   1 
ATOM   734  C CD1   . ILE A 1 137 ? 103.894 110.091 133.705 1.00 462.10 ? 137 ILE A CD1   1 
ATOM   735  N N     . GLN A 1 138 ? 98.684  111.127 131.607 1.00 352.10 ? 138 GLN A N     1 
ATOM   736  C CA    . GLN A 1 138 ? 98.056  111.419 130.324 1.00 352.10 ? 138 GLN A CA    1 
ATOM   737  C C     . GLN A 1 138 ? 99.028  112.249 129.493 1.00 352.10 ? 138 GLN A C     1 
ATOM   738  O O     . GLN A 1 138 ? 99.431  113.340 129.912 1.00 352.10 ? 138 GLN A O     1 
ATOM   739  C CB    . GLN A 1 138 ? 96.738  112.171 130.519 1.00 352.10 ? 138 GLN A CB    1 
ATOM   740  C CG    . GLN A 1 138 ? 96.191  112.813 129.251 1.00 352.10 ? 138 GLN A CG    1 
ATOM   741  C CD    . GLN A 1 138 ? 95.677  111.795 128.247 1.00 352.10 ? 138 GLN A CD    1 
ATOM   742  O OE1   . GLN A 1 138 ? 95.407  110.644 128.596 1.00 352.10 ? 138 GLN A OE1   1 
ATOM   743  N NE2   . GLN A 1 138 ? 95.550  112.213 126.993 1.00 352.10 ? 138 GLN A NE2   1 
ATOM   744  N N     . ASN A 1 139 ? 99.425  111.715 128.334 1.00 278.41 ? 139 ASN A N     1 
ATOM   745  C CA    . ASN A 1 139 ? 100.477 112.294 127.495 1.00 278.41 ? 139 ASN A CA    1 
ATOM   746  C C     . ASN A 1 139 ? 101.822 112.188 128.220 1.00 278.41 ? 139 ASN A C     1 
ATOM   747  O O     . ASN A 1 139 ? 102.437 113.177 128.623 1.00 278.41 ? 139 ASN A O     1 
ATOM   748  C CB    . ASN A 1 139 ? 100.156 113.739 127.091 1.00 278.41 ? 139 ASN A CB    1 
ATOM   749  C CG    . ASN A 1 139 ? 101.125 114.290 126.064 1.00 278.41 ? 139 ASN A CG    1 
ATOM   750  O OD1   . ASN A 1 139 ? 102.004 113.579 125.574 1.00 278.41 ? 139 ASN A OD1   1 
ATOM   751  N ND2   . ASN A 1 139 ? 100.960 115.564 125.723 1.00 278.41 ? 139 ASN A ND2   1 
ATOM   752  N N     . GLY A 1 140 ? 102.262 110.939 128.367 1.00 356.55 ? 140 GLY A N     1 
ATOM   753  C CA    . GLY A 1 140 ? 103.461 110.650 129.137 1.00 356.55 ? 140 GLY A CA    1 
ATOM   754  C C     . GLY A 1 140 ? 104.740 111.154 128.502 1.00 356.55 ? 140 GLY A C     1 
ATOM   755  O O     . GLY A 1 140 ? 105.680 111.534 129.201 1.00 356.55 ? 140 GLY A O     1 
ATOM   756  N N     . LYS A 1 141 ? 104.803 111.157 127.169 1.00 346.14 ? 141 LYS A N     1 
ATOM   757  C CA    . LYS A 1 141 ? 105.997 111.664 126.497 1.00 346.14 ? 141 LYS A CA    1 
ATOM   758  C C     . LYS A 1 141 ? 106.237 113.134 126.802 1.00 346.14 ? 141 LYS A C     1 
ATOM   759  O O     . LYS A 1 141 ? 107.363 113.532 127.112 1.00 346.14 ? 141 LYS A O     1 
ATOM   760  C CB    . LYS A 1 141 ? 105.869 111.460 124.992 1.00 346.14 ? 141 LYS A CB    1 
ATOM   761  C CG    . LYS A 1 141 ? 107.154 111.706 124.234 1.00 346.14 ? 141 LYS A CG    1 
ATOM   762  C CD    . LYS A 1 141 ? 106.897 111.705 122.750 1.00 346.14 ? 141 LYS A CD    1 
ATOM   763  C CE    . LYS A 1 141 ? 106.256 113.007 122.293 1.00 346.14 ? 141 LYS A CE    1 
ATOM   764  N NZ    . LYS A 1 141 ? 106.134 113.069 120.810 1.00 346.14 ? 141 LYS A NZ    1 
ATOM   765  N N     . PHE A 1 142 ? 105.182 113.942 126.773 1.00 339.31 ? 142 PHE A N     1 
ATOM   766  C CA    . PHE A 1 142 ? 105.314 115.374 127.022 1.00 339.31 ? 142 PHE A CA    1 
ATOM   767  C C     . PHE A 1 142 ? 105.803 115.637 128.444 1.00 339.31 ? 142 PHE A C     1 
ATOM   768  O O     . PHE A 1 142 ? 106.784 116.372 128.661 1.00 339.31 ? 142 PHE A O     1 
ATOM   769  C CB    . PHE A 1 142 ? 103.967 116.041 126.750 1.00 339.31 ? 142 PHE A CB    1 
ATOM   770  C CG    . PHE A 1 142 ? 103.945 117.515 126.986 1.00 339.31 ? 142 PHE A CG    1 
ATOM   771  C CD1   . PHE A 1 142 ? 104.281 118.391 125.968 1.00 339.31 ? 142 PHE A CD1   1 
ATOM   772  C CD2   . PHE A 1 142 ? 103.535 118.029 128.200 1.00 339.31 ? 142 PHE A CD2   1 
ATOM   773  C CE1   . PHE A 1 142 ? 104.246 119.753 126.170 1.00 339.31 ? 142 PHE A CE1   1 
ATOM   774  C CE2   . PHE A 1 142 ? 103.494 119.388 128.407 1.00 339.31 ? 142 PHE A CE2   1 
ATOM   775  C CZ    . PHE A 1 142 ? 103.849 120.251 127.390 1.00 339.31 ? 142 PHE A CZ    1 
ATOM   776  N N     . ASP A 1 143 ? 105.164 114.998 129.424 1.00 316.07 ? 143 ASP A N     1 
ATOM   777  C CA    . ASP A 1 143 ? 105.512 115.245 130.815 1.00 316.07 ? 143 ASP A CA    1 
ATOM   778  C C     . ASP A 1 143 ? 106.897 114.696 131.120 1.00 316.07 ? 143 ASP A C     1 
ATOM   779  O O     . ASP A 1 143 ? 107.689 115.343 131.815 1.00 316.07 ? 143 ASP A O     1 
ATOM   780  C CB    . ASP A 1 143 ? 104.462 114.620 131.731 1.00 316.07 ? 143 ASP A CB    1 
ATOM   781  C CG    . ASP A 1 143 ? 103.078 115.199 131.508 1.00 316.07 ? 143 ASP A CG    1 
ATOM   782  O OD1   . ASP A 1 143 ? 102.926 116.035 130.593 1.00 316.07 ? 143 ASP A OD1   1 
ATOM   783  O OD2   . ASP A 1 143 ? 102.146 114.818 132.244 1.00 316.07 ? 143 ASP A OD2   1 
ATOM   784  N N     . ALA A 1 144 ? 107.188 113.478 130.659 1.00 282.06 ? 144 ALA A N     1 
ATOM   785  C CA    . ALA A 1 144 ? 108.504 112.906 130.904 1.00 282.06 ? 144 ALA A CA    1 
ATOM   786  C C     . ALA A 1 144 ? 109.582 113.768 130.265 1.00 282.06 ? 144 ALA A C     1 
ATOM   787  O O     . ALA A 1 144 ? 110.669 113.930 130.827 1.00 282.06 ? 144 ALA A O     1 
ATOM   788  C CB    . ALA A 1 144 ? 108.566 111.476 130.372 1.00 282.06 ? 144 ALA A CB    1 
ATOM   789  N N     . LYS A 1 145 ? 109.305 114.310 129.075 1.00 309.65 ? 145 LYS A N     1 
ATOM   790  C CA    . LYS A 1 145 ? 110.246 115.205 128.410 1.00 309.65 ? 145 LYS A CA    1 
ATOM   791  C C     . LYS A 1 145 ? 110.566 116.401 129.289 1.00 309.65 ? 145 LYS A C     1 
ATOM   792  O O     . LYS A 1 145 ? 111.738 116.734 129.517 1.00 309.65 ? 145 LYS A O     1 
ATOM   793  C CB    . LYS A 1 145 ? 109.651 115.665 127.081 1.00 309.65 ? 145 LYS A CB    1 
ATOM   794  C CG    . LYS A 1 145 ? 110.656 115.950 125.995 1.00 309.65 ? 145 LYS A CG    1 
ATOM   795  C CD    . LYS A 1 145 ? 109.952 116.176 124.665 1.00 309.65 ? 145 LYS A CD    1 
ATOM   796  C CE    . LYS A 1 145 ? 108.824 117.188 124.801 1.00 309.65 ? 145 LYS A CE    1 
ATOM   797  N NZ    . LYS A 1 145 ? 108.124 117.422 123.510 1.00 309.65 ? 145 LYS A NZ    1 
ATOM   798  N N     . PHE A 1 146 ? 109.520 117.056 129.800 1.00 431.62 ? 146 PHE A N     1 
ATOM   799  C CA    . PHE A 1 146 ? 109.730 118.198 130.684 1.00 431.62 ? 146 PHE A CA    1 
ATOM   800  C C     . PHE A 1 146 ? 110.505 117.804 131.937 1.00 431.62 ? 146 PHE A C     1 
ATOM   801  O O     . PHE A 1 146 ? 111.442 118.505 132.340 1.00 431.62 ? 146 PHE A O     1 
ATOM   802  C CB    . PHE A 1 146 ? 108.398 118.855 131.036 1.00 431.62 ? 146 PHE A CB    1 
ATOM   803  C CG    . PHE A 1 146 ? 108.016 119.964 130.094 1.00 431.62 ? 146 PHE A CG    1 
ATOM   804  C CD1   . PHE A 1 146 ? 107.463 119.685 128.857 1.00 431.62 ? 146 PHE A CD1   1 
ATOM   805  C CD2   . PHE A 1 146 ? 108.243 121.288 130.439 1.00 431.62 ? 146 PHE A CD2   1 
ATOM   806  C CE1   . PHE A 1 146 ? 107.125 120.706 127.986 1.00 431.62 ? 146 PHE A CE1   1 
ATOM   807  C CE2   . PHE A 1 146 ? 107.908 122.315 129.574 1.00 431.62 ? 146 PHE A CE2   1 
ATOM   808  C CZ    . PHE A 1 146 ? 107.347 122.023 128.346 1.00 431.62 ? 146 PHE A CZ    1 
ATOM   809  N N     . LEU A 1 147 ? 110.128 116.693 132.571 1.00 372.13 ? 147 LEU A N     1 
ATOM   810  C CA    . LEU A 1 147 ? 110.791 116.283 133.806 1.00 372.13 ? 147 LEU A CA    1 
ATOM   811  C C     . LEU A 1 147 ? 112.263 115.972 133.566 1.00 372.13 ? 147 LEU A C     1 
ATOM   812  O O     . LEU A 1 147 ? 113.124 116.320 134.382 1.00 372.13 ? 147 LEU A O     1 
ATOM   813  C CB    . LEU A 1 147 ? 110.077 115.069 134.402 1.00 372.13 ? 147 LEU A CB    1 
ATOM   814  C CG    . LEU A 1 147 ? 108.676 115.302 134.968 1.00 372.13 ? 147 LEU A CG    1 
ATOM   815  C CD1   . LEU A 1 147 ? 107.997 113.976 135.269 1.00 372.13 ? 147 LEU A CD1   1 
ATOM   816  C CD2   . LEU A 1 147 ? 108.741 116.171 136.213 1.00 372.13 ? 147 LEU A CD2   1 
ATOM   817  N N     . LEU A 1 148 ? 112.574 115.320 132.445 1.00 320.68 ? 148 LEU A N     1 
ATOM   818  C CA    . LEU A 1 148 ? 113.965 115.009 132.139 1.00 320.68 ? 148 LEU A CA    1 
ATOM   819  C C     . LEU A 1 148 ? 114.760 116.277 131.861 1.00 320.68 ? 148 LEU A C     1 
ATOM   820  O O     . LEU A 1 148 ? 115.893 116.423 132.338 1.00 320.68 ? 148 LEU A O     1 
ATOM   821  C CB    . LEU A 1 148 ? 114.044 114.052 130.952 1.00 320.68 ? 148 LEU A CB    1 
ATOM   822  C CG    . LEU A 1 148 ? 113.558 112.628 131.228 1.00 320.68 ? 148 LEU A CG    1 
ATOM   823  C CD1   . LEU A 1 148 ? 113.434 111.841 129.933 1.00 320.68 ? 148 LEU A CD1   1 
ATOM   824  C CD2   . LEU A 1 148 ? 114.486 111.924 132.207 1.00 320.68 ? 148 LEU A CD2   1 
ATOM   825  N N     . HIS A 1 149 ? 114.190 117.202 131.083 1.00 512.71 ? 149 HIS A N     1 
ATOM   826  C CA    . HIS A 1 149 ? 114.904 118.438 130.779 1.00 512.71 ? 149 HIS A CA    1 
ATOM   827  C C     . HIS A 1 149 ? 115.147 119.274 132.031 1.00 512.71 ? 149 HIS A C     1 
ATOM   828  O O     . HIS A 1 149 ? 116.105 120.054 132.078 1.00 512.71 ? 149 HIS A O     1 
ATOM   829  C CB    . HIS A 1 149 ? 114.128 119.249 129.743 1.00 512.71 ? 149 HIS A CB    1 
ATOM   830  C CG    . HIS A 1 149 ? 114.808 120.520 129.338 1.00 512.71 ? 149 HIS A CG    1 
ATOM   831  N ND1   . HIS A 1 149 ? 116.036 120.540 128.712 1.00 512.71 ? 149 HIS A ND1   1 
ATOM   832  C CD2   . HIS A 1 149 ? 114.432 121.813 129.469 1.00 512.71 ? 149 HIS A CD2   1 
ATOM   833  C CE1   . HIS A 1 149 ? 116.386 121.792 128.476 1.00 512.71 ? 149 HIS A CE1   1 
ATOM   834  N NE2   . HIS A 1 149 ? 115.430 122.584 128.925 1.00 512.71 ? 149 HIS A NE2   1 
ATOM   835  N N     . ASN A 1 150 ? 114.301 119.126 133.050 1.00 505.19 ? 150 ASN A N     1 
ATOM   836  C CA    . ASN A 1 150 ? 114.453 119.836 134.312 1.00 505.19 ? 150 ASN A CA    1 
ATOM   837  C C     . ASN A 1 150 ? 115.159 118.999 135.374 1.00 505.19 ? 150 ASN A C     1 
ATOM   838  O O     . ASN A 1 150 ? 114.959 119.238 136.572 1.00 505.19 ? 150 ASN A O     1 
ATOM   839  C CB    . ASN A 1 150 ? 113.089 120.297 134.825 1.00 505.19 ? 150 ASN A CB    1 
ATOM   840  C CG    . ASN A 1 150 ? 112.530 121.464 134.034 1.00 505.19 ? 150 ASN A CG    1 
ATOM   841  O OD1   . ASN A 1 150 ? 112.531 122.603 134.502 1.00 505.19 ? 150 ASN A OD1   1 
ATOM   842  N ND2   . ASN A 1 150 ? 112.046 121.186 132.830 1.00 505.19 ? 150 ASN A ND2   1 
ATOM   843  N N     . ASN A 1 151 ? 115.976 118.027 134.964 1.00 492.34 ? 151 ASN A N     1 
ATOM   844  C CA    . ASN A 1 151 ? 116.792 117.205 135.853 1.00 492.34 ? 151 ASN A CA    1 
ATOM   845  C C     . ASN A 1 151 ? 115.949 116.474 136.887 1.00 492.34 ? 151 ASN A C     1 
ATOM   846  O O     . ASN A 1 151 ? 116.302 116.436 138.070 1.00 492.34 ? 151 ASN A O     1 
ATOM   847  C CB    . ASN A 1 151 ? 117.873 118.033 136.559 1.00 492.34 ? 151 ASN A CB    1 
ATOM   848  C CG    . ASN A 1 151 ? 118.846 118.669 135.587 1.00 492.34 ? 151 ASN A CG    1 
ATOM   849  O OD1   . ASN A 1 151 ? 119.113 118.127 134.514 1.00 492.34 ? 151 ASN A OD1   1 
ATOM   850  N ND2   . ASN A 1 151 ? 119.380 119.826 135.959 1.00 492.34 ? 151 ASN A ND2   1 
ATOM   851  N N     . PHE A 1 152 ? 114.837 115.891 136.459 1.00 423.45 ? 152 PHE A N     1 
ATOM   852  C CA    . PHE A 1 152 ? 114.078 114.933 137.245 1.00 423.45 ? 152 PHE A CA    1 
ATOM   853  C C     . PHE A 1 152 ? 114.185 113.545 136.629 1.00 423.45 ? 152 PHE A C     1 
ATOM   854  O O     . PHE A 1 152 ? 114.049 113.373 135.415 1.00 423.45 ? 152 PHE A O     1 
ATOM   855  C CB    . PHE A 1 152 ? 112.610 115.351 137.341 1.00 423.45 ? 152 PHE A CB    1 
ATOM   856  C CG    . PHE A 1 152 ? 112.356 116.450 138.333 1.00 423.45 ? 152 PHE A CG    1 
ATOM   857  C CD1   . PHE A 1 152 ? 112.226 116.170 139.682 1.00 423.45 ? 152 PHE A CD1   1 
ATOM   858  C CD2   . PHE A 1 152 ? 112.245 117.766 137.913 1.00 423.45 ? 152 PHE A CD2   1 
ATOM   859  C CE1   . PHE A 1 152 ? 111.988 117.180 140.595 1.00 423.45 ? 152 PHE A CE1   1 
ATOM   860  C CE2   . PHE A 1 152 ? 112.008 118.781 138.821 1.00 423.45 ? 152 PHE A CE2   1 
ATOM   861  C CZ    . PHE A 1 152 ? 111.881 118.486 140.164 1.00 423.45 ? 152 PHE A CZ    1 
ATOM   862  N N     . LYS A 1 153 ? 114.433 112.552 137.476 1.00 398.55 ? 153 LYS A N     1 
ATOM   863  C CA    . LYS A 1 153 ? 114.491 111.166 137.039 1.00 398.55 ? 153 LYS A CA    1 
ATOM   864  C C     . LYS A 1 153 ? 113.142 110.517 137.302 1.00 398.55 ? 153 LYS A C     1 
ATOM   865  O O     . LYS A 1 153 ? 112.512 110.765 138.336 1.00 398.55 ? 153 LYS A O     1 
ATOM   866  C CB    . LYS A 1 153 ? 115.590 110.399 137.778 1.00 398.55 ? 153 LYS A CB    1 
ATOM   867  C CG    . LYS A 1 153 ? 117.003 110.852 137.455 1.00 398.55 ? 153 LYS A CG    1 
ATOM   868  C CD    . LYS A 1 153 ? 118.007 110.173 138.372 1.00 398.55 ? 153 LYS A CD    1 
ATOM   869  C CE    . LYS A 1 153 ? 119.423 110.650 138.097 1.00 398.55 ? 153 LYS A CE    1 
ATOM   870  N NZ    . LYS A 1 153 ? 120.402 110.038 139.036 1.00 398.55 ? 153 LYS A NZ    1 
ATOM   871  N N     . ILE A 1 154 ? 112.708 109.679 136.367 1.00 381.44 ? 154 ILE A N     1 
ATOM   872  C CA    . ILE A 1 154 ? 111.398 109.043 136.429 1.00 381.44 ? 154 ILE A CA    1 
ATOM   873  C C     . ILE A 1 154 ? 111.493 107.654 135.817 1.00 381.44 ? 154 ILE A C     1 
ATOM   874  O O     . ILE A 1 154 ? 112.234 107.437 134.853 1.00 381.44 ? 154 ILE A O     1 
ATOM   875  C CB    . ILE A 1 154 ? 110.331 109.901 135.714 1.00 381.44 ? 154 ILE A CB    1 
ATOM   876  C CG1   . ILE A 1 154 ? 108.947 109.258 135.825 1.00 381.44 ? 154 ILE A CG1   1 
ATOM   877  C CG2   . ILE A 1 154 ? 110.715 110.137 134.258 1.00 381.44 ? 154 ILE A CG2   1 
ATOM   878  C CD1   . ILE A 1 154 ? 107.823 110.150 135.353 1.00 381.44 ? 154 ILE A CD1   1 
ATOM   879  N N     . GLU A 1 155 ? 110.720 106.718 136.367 1.00 371.40 ? 155 GLU A N     1 
ATOM   880  C CA    . GLU A 1 155 ? 110.638 105.351 135.873 1.00 371.40 ? 155 GLU A CA    1 
ATOM   881  C C     . GLU A 1 155 ? 109.300 104.770 136.303 1.00 371.40 ? 155 GLU A C     1 
ATOM   882  O O     . GLU A 1 155 ? 108.755 105.135 137.349 1.00 371.40 ? 155 GLU A O     1 
ATOM   883  C CB    . GLU A 1 155 ? 111.756 104.437 136.420 1.00 371.40 ? 155 GLU A CB    1 
ATOM   884  C CG    . GLU A 1 155 ? 113.192 104.940 136.312 1.00 371.40 ? 155 GLU A CG    1 
ATOM   885  C CD    . GLU A 1 155 ? 113.759 104.846 134.910 1.00 371.40 ? 155 GLU A CD    1 
ATOM   886  O OE1   . GLU A 1 155 ? 113.015 104.465 133.981 1.00 371.40 ? 155 GLU A OE1   1 
ATOM   887  O OE2   . GLU A 1 155 ? 114.955 105.159 134.734 1.00 371.40 ? 155 GLU A OE2   1 
ATOM   888  N N     . ASN A 1 156 ? 108.760 103.894 135.450 1.00 379.13 ? 156 ASN A N     1 
ATOM   889  C CA    . ASN A 1 156 ? 107.463 103.243 135.647 1.00 379.13 ? 156 ASN A CA    1 
ATOM   890  C C     . ASN A 1 156 ? 106.317 104.221 135.360 1.00 379.13 ? 156 ASN A C     1 
ATOM   891  O O     . ASN A 1 156 ? 105.883 104.991 136.216 1.00 379.13 ? 156 ASN A O     1 
ATOM   892  C CB    . ASN A 1 156 ? 107.342 102.631 137.052 1.00 379.13 ? 156 ASN A CB    1 
ATOM   893  C CG    . ASN A 1 156 ? 106.164 101.681 137.182 1.00 379.13 ? 156 ASN A CG    1 
ATOM   894  O OD1   . ASN A 1 156 ? 105.221 101.723 136.392 1.00 379.13 ? 156 ASN A OD1   1 
ATOM   895  N ND2   . ASN A 1 156 ? 106.214 100.818 138.190 1.00 379.13 ? 156 ASN A ND2   1 
ATOM   896  N N     . ILE A 1 157 ? 105.828 104.159 134.124 1.00 482.32 ? 157 ILE A N     1 
ATOM   897  C CA    . ILE A 1 157 ? 104.821 105.093 133.633 1.00 482.32 ? 157 ILE A CA    1 
ATOM   898  C C     . ILE A 1 157 ? 103.722 104.277 132.965 1.00 482.32 ? 157 ILE A C     1 
ATOM   899  O O     . ILE A 1 157 ? 103.999 103.257 132.321 1.00 482.32 ? 157 ILE A O     1 
ATOM   900  C CB    . ILE A 1 157 ? 105.436 106.117 132.664 1.00 482.32 ? 157 ILE A CB    1 
ATOM   901  C CG1   . ILE A 1 157 ? 106.410 107.031 133.413 1.00 482.32 ? 157 ILE A CG1   1 
ATOM   902  C CG2   . ILE A 1 157 ? 104.361 106.950 131.990 1.00 482.32 ? 157 ILE A CG2   1 
ATOM   903  C CD1   . ILE A 1 157 ? 107.242 107.909 132.508 1.00 482.32 ? 157 ILE A CD1   1 
ATOM   904  N N     . PHE A 1 158 ? 102.472 104.725 133.113 1.00 473.33 ? 158 PHE A N     1 
ATOM   905  C CA    . PHE A 1 158 ? 101.263 104.182 132.482 1.00 473.33 ? 158 PHE A CA    1 
ATOM   906  C C     . PHE A 1 158 ? 100.527 105.294 131.709 1.00 473.33 ? 158 PHE A C     1 
ATOM   907  O O     . PHE A 1 158 ? 99.838  106.095 132.341 1.00 473.33 ? 158 PHE A O     1 
ATOM   908  C CB    . PHE A 1 158 ? 100.387 103.587 133.599 1.00 473.33 ? 158 PHE A CB    1 
ATOM   909  C CG    . PHE A 1 158 ? 99.127  102.879 133.140 1.00 473.33 ? 158 PHE A CG    1 
ATOM   910  C CD1   . PHE A 1 158 ? 97.936  103.583 132.863 1.00 473.33 ? 158 PHE A CD1   1 
ATOM   911  C CD2   . PHE A 1 158 ? 99.136  101.476 133.044 1.00 473.33 ? 158 PHE A CD2   1 
ATOM   912  C CE1   . PHE A 1 158 ? 96.773  102.880 132.497 1.00 473.33 ? 158 PHE A CE1   1 
ATOM   913  C CE2   . PHE A 1 158 ? 97.971  100.777 132.689 1.00 473.33 ? 158 PHE A CE2   1 
ATOM   914  C CZ    . PHE A 1 158 ? 96.789  101.479 132.417 1.00 473.33 ? 158 PHE A CZ    1 
ATOM   915  N N     . ASP A 1 159 ? 100.694 105.399 130.376 1.00 477.56 ? 159 ASP A N     1 
ATOM   916  C CA    . ASP A 1 159 ? 100.052 106.464 129.608 1.00 477.56 ? 159 ASP A CA    1 
ATOM   917  C C     . ASP A 1 159 ? 98.664  105.974 129.199 1.00 477.56 ? 159 ASP A C     1 
ATOM   918  O O     . ASP A 1 159 ? 98.536  105.077 128.359 1.00 477.56 ? 159 ASP A O     1 
ATOM   919  C CB    . ASP A 1 159 ? 100.881 106.840 128.378 1.00 477.56 ? 159 ASP A CB    1 
ATOM   920  C CG    . ASP A 1 159 ? 100.398 108.116 127.709 1.00 477.56 ? 159 ASP A CG    1 
ATOM   921  O OD1   . ASP A 1 159 ? 99.242  108.526 127.941 1.00 477.56 ? 159 ASP A OD1   1 
ATOM   922  O OD2   . ASP A 1 159 ? 101.181 108.709 126.938 1.00 477.56 ? 159 ASP A OD2   1 
ATOM   923  N N     . THR A 1 160 ? 97.631  106.571 129.799 1.00 431.25 ? 160 THR A N     1 
ATOM   924  C CA    . THR A 1 160 ? 96.235  106.243 129.500 1.00 431.25 ? 160 THR A CA    1 
ATOM   925  C C     . THR A 1 160 ? 95.813  106.540 128.059 1.00 431.25 ? 160 THR A C     1 
ATOM   926  O O     . THR A 1 160 ? 94.898  105.887 127.546 1.00 431.25 ? 160 THR A O     1 
ATOM   927  C CB    . THR A 1 160 ? 95.318  106.993 130.466 1.00 431.25 ? 160 THR A CB    1 
ATOM   928  O OG1   . THR A 1 160 ? 95.529  108.405 130.326 1.00 431.25 ? 160 THR A OG1   1 
ATOM   929  C CG2   . THR A 1 160 ? 95.621  106.586 131.902 1.00 431.25 ? 160 THR A CG2   1 
ATOM   930  N N     . TYR A 1 161 ? 96.474  107.480 127.378 1.00 367.68 ? 161 TYR A N     1 
ATOM   931  C CA    . TYR A 1 161 ? 96.132  107.756 125.981 1.00 367.68 ? 161 TYR A CA    1 
ATOM   932  C C     . TYR A 1 161 ? 96.535  106.627 125.037 1.00 367.68 ? 161 TYR A C     1 
ATOM   933  O O     . TYR A 1 161 ? 95.780  106.277 124.121 1.00 367.68 ? 161 TYR A O     1 
ATOM   934  C CB    . TYR A 1 161 ? 96.777  109.074 125.544 1.00 367.68 ? 161 TYR A CB    1 
ATOM   935  C CG    . TYR A 1 161 ? 96.864  109.251 124.043 1.00 367.68 ? 161 TYR A CG    1 
ATOM   936  C CD1   . TYR A 1 161 ? 95.778  109.721 123.322 1.00 367.68 ? 161 TYR A CD1   1 
ATOM   937  C CD2   . TYR A 1 161 ? 98.040  108.972 123.351 1.00 367.68 ? 161 TYR A CD2   1 
ATOM   938  C CE1   . TYR A 1 161 ? 95.847  109.893 121.954 1.00 367.68 ? 161 TYR A CE1   1 
ATOM   939  C CE2   . TYR A 1 161 ? 98.119  109.142 121.979 1.00 367.68 ? 161 TYR A CE2   1 
ATOM   940  C CZ    . TYR A 1 161 ? 97.019  109.603 121.288 1.00 367.68 ? 161 TYR A CZ    1 
ATOM   941  O OH    . TYR A 1 161 ? 97.090  109.774 119.925 1.00 367.68 ? 161 TYR A OH    1 
ATOM   942  N N     . ILE A 1 162 ? 97.700  106.021 125.254 1.00 307.55 ? 162 ILE A N     1 
ATOM   943  C CA    . ILE A 1 162 ? 98.107  104.914 124.391 1.00 307.55 ? 162 ILE A CA    1 
ATOM   944  C C     . ILE A 1 162 ? 97.179  103.722 124.596 1.00 307.55 ? 162 ILE A C     1 
ATOM   945  O O     . ILE A 1 162 ? 96.760  103.066 123.634 1.00 307.55 ? 162 ILE A O     1 
ATOM   946  C CB    . ILE A 1 162 ? 99.587  104.566 124.620 1.00 307.55 ? 162 ILE A CB    1 
ATOM   947  C CG1   . ILE A 1 162 ? 100.463 105.661 124.000 1.00 307.55 ? 162 ILE A CG1   1 
ATOM   948  C CG2   . ILE A 1 162 ? 99.918  103.194 124.042 1.00 307.55 ? 162 ILE A CG2   1 
ATOM   949  C CD1   . ILE A 1 162 ? 101.936 105.529 124.267 1.00 307.55 ? 162 ILE A CD1   1 
ATOM   950  N N     . ALA A 1 163 ? 96.816  103.449 125.851 1.00 335.09 ? 163 ALA A N     1 
ATOM   951  C CA    . ALA A 1 163 ? 95.903  102.353 126.160 1.00 335.09 ? 163 ALA A CA    1 
ATOM   952  C C     . ALA A 1 163 ? 94.530  102.603 125.541 1.00 335.09 ? 163 ALA A C     1 
ATOM   953  O O     . ALA A 1 163 ? 93.906  101.686 124.997 1.00 335.09 ? 163 ALA A O     1 
ATOM   954  C CB    . ALA A 1 163 ? 95.807  102.159 127.669 1.00 335.09 ? 163 ALA A CB    1 
ATOM   955  N N     . SER A 1 164 ? 94.031  103.840 125.639 1.00 333.81 ? 164 SER A N     1 
ATOM   956  C CA    . SER A 1 164 ? 92.725  104.155 125.061 1.00 333.81 ? 164 SER A CA    1 
ATOM   957  C C     . SER A 1 164 ? 92.760  104.000 123.544 1.00 333.81 ? 164 SER A C     1 
ATOM   958  O O     . SER A 1 164 ? 91.806  103.499 122.933 1.00 333.81 ? 164 SER A O     1 
ATOM   959  C CB    . SER A 1 164 ? 92.295  105.565 125.455 1.00 333.81 ? 164 SER A CB    1 
ATOM   960  O OG    . SER A 1 164 ? 91.045  105.893 124.874 1.00 333.81 ? 164 SER A OG    1 
ATOM   961  N N     . LYS A 1 165 ? 93.868  104.410 122.923 1.00 311.44 ? 165 LYS A N     1 
ATOM   962  C CA    . LYS A 1 165 ? 94.014  104.301 121.474 1.00 311.44 ? 165 LYS A CA    1 
ATOM   963  C C     . LYS A 1 165 ? 94.012  102.831 121.084 1.00 311.44 ? 165 LYS A C     1 
ATOM   964  O O     . LYS A 1 165 ? 93.422  102.437 120.072 1.00 311.44 ? 165 LYS A O     1 
ATOM   965  C CB    . LYS A 1 165 ? 95.292  105.002 121.013 1.00 311.44 ? 165 LYS A CB    1 
ATOM   966  C CG    . LYS A 1 165 ? 95.244  105.474 119.564 1.00 311.44 ? 165 LYS A CG    1 
ATOM   967  C CD    . LYS A 1 165 ? 96.386  106.431 119.260 1.00 311.44 ? 165 LYS A CD    1 
ATOM   968  C CE    . LYS A 1 165 ? 96.484  106.731 117.788 1.00 311.44 ? 165 LYS A CE    1 
ATOM   969  N NZ    . LYS A 1 165 ? 97.694  107.527 117.480 1.00 311.44 ? 165 LYS A NZ    1 
ATOM   970  N N     . LEU A 1 166 ? 94.550  101.963 121.942 1.00 360.81 ? 166 LEU A N     1 
ATOM   971  C CA    . LEU A 1 166 ? 94.480  100.504 121.801 1.00 360.81 ? 166 LEU A CA    1 
ATOM   972  C C     . LEU A 1 166 ? 93.115  99.901  122.099 1.00 360.81 ? 166 LEU A C     1 
ATOM   973  O O     . LEU A 1 166 ? 92.712  98.977  121.398 1.00 360.81 ? 166 LEU A O     1 
ATOM   974  C CB    . LEU A 1 166 ? 95.514  99.847  122.714 1.00 360.81 ? 166 LEU A CB    1 
ATOM   975  C CG    . LEU A 1 166 ? 96.918  100.230 122.268 1.00 360.81 ? 166 LEU A CG    1 
ATOM   976  C CD1   . LEU A 1 166 ? 97.896  100.023 123.401 1.00 360.81 ? 166 LEU A CD1   1 
ATOM   977  C CD2   . LEU A 1 166 ? 97.324  99.411  121.044 1.00 360.81 ? 166 LEU A CD2   1 
ATOM   978  N N     . LEU A 1 167 ? 92.358  100.448 123.053 1.00 349.18 ? 167 LEU A N     1 
ATOM   979  C CA    . LEU A 1 167 ? 90.935  100.129 123.155 1.00 349.18 ? 167 LEU A CA    1 
ATOM   980  C C     . LEU A 1 167 ? 90.205  100.501 121.864 1.00 349.18 ? 167 LEU A C     1 
ATOM   981  O O     . LEU A 1 167 ? 89.146  99.937  121.594 1.00 349.18 ? 167 LEU A O     1 
ATOM   982  C CB    . LEU A 1 167 ? 90.231  100.853 124.316 1.00 349.18 ? 167 LEU A CB    1 
ATOM   983  C CG    . LEU A 1 167 ? 90.741  100.623 125.745 1.00 349.18 ? 167 LEU A CG    1 
ATOM   984  C CD1   . LEU A 1 167 ? 89.582  100.928 126.697 1.00 349.18 ? 167 LEU A CD1   1 
ATOM   985  C CD2   . LEU A 1 167 ? 91.222  99.200  126.004 1.00 349.18 ? 167 LEU A CD2   1 
ATOM   986  N N     . ASP A 1 168 ? 90.743  101.431 121.069 1.00 393.55 ? 168 ASP A N     1 
ATOM   987  C CA    . ASP A 1 168 ? 90.026  101.858 119.877 1.00 393.55 ? 168 ASP A CA    1 
ATOM   988  C C     . ASP A 1 168 ? 90.410  100.984 118.689 1.00 393.55 ? 168 ASP A C     1 
ATOM   989  O O     . ASP A 1 168 ? 89.645  100.884 117.722 1.00 393.55 ? 168 ASP A O     1 
ATOM   990  C CB    . ASP A 1 168 ? 90.314  103.329 119.582 1.00 393.55 ? 168 ASP A CB    1 
ATOM   991  C CG    . ASP A 1 168 ? 89.591  103.827 118.346 1.00 393.55 ? 168 ASP A CG    1 
ATOM   992  O OD1   . ASP A 1 168 ? 88.347  103.931 118.379 1.00 393.55 ? 168 ASP A OD1   1 
ATOM   993  O OD2   . ASP A 1 168 ? 90.269  104.112 117.336 1.00 393.55 ? 168 ASP A OD2   1 
ATOM   994  N N     . LYS A 1 169 ? 91.513  100.229 118.771 1.00 365.10 ? 169 LYS A N     1 
ATOM   995  C CA    . LYS A 1 169 ? 91.984  99.302  117.728 1.00 365.10 ? 169 LYS A CA    1 
ATOM   996  C C     . LYS A 1 169 ? 92.141  99.960  116.351 1.00 365.10 ? 169 LYS A C     1 
ATOM   997  O O     . LYS A 1 169 ? 91.927  99.304  115.331 1.00 365.10 ? 169 LYS A O     1 
ATOM   998  C CB    . LYS A 1 169 ? 91.126  98.022  117.623 1.00 365.10 ? 169 LYS A CB    1 
ATOM   999  C CG    . LYS A 1 169 ? 90.793  97.288  118.924 1.00 365.10 ? 169 LYS A CG    1 
ATOM   1000 C CD    . LYS A 1 169 ? 89.366  97.603  119.381 1.00 365.10 ? 169 LYS A CD    1 
ATOM   1001 C CE    . LYS A 1 169 ? 89.104  96.964  120.747 1.00 365.10 ? 169 LYS A CE    1 
ATOM   1002 N NZ    . LYS A 1 169 ? 87.823  97.442  121.327 1.00 365.10 ? 169 LYS A NZ    1 
ATOM   1003 N N     . ASN A 1 170 ? 92.502  101.249 116.302 1.00 451.81 ? 170 ASN A N     1 
ATOM   1004 C CA    . ASN A 1 170 ? 92.700  101.982 115.057 1.00 451.81 ? 170 ASN A CA    1 
ATOM   1005 C C     . ASN A 1 170 ? 91.417  102.046 114.244 1.00 451.81 ? 170 ASN A C     1 
ATOM   1006 O O     . ASN A 1 170 ? 91.443  101.974 113.011 1.00 451.81 ? 170 ASN A O     1 
ATOM   1007 C CB    . ASN A 1 170 ? 93.839  101.378 114.223 1.00 451.81 ? 170 ASN A CB    1 
ATOM   1008 C CG    . ASN A 1 170 ? 94.239  102.259 113.051 1.00 451.81 ? 170 ASN A CG    1 
ATOM   1009 O OD1   . ASN A 1 170 ? 95.134  103.095 113.162 1.00 451.81 ? 170 ASN A OD1   1 
ATOM   1010 N ND2   . ASN A 1 170 ? 93.569  102.074 111.917 1.00 451.81 ? 170 ASN A ND2   1 
ATOM   1011 N N     . LYS A 1 171 ? 90.280  102.164 114.928 1.00 492.51 ? 171 LYS A N     1 
ATOM   1012 C CA    . LYS A 1 171 ? 89.017  102.393 114.242 1.00 492.51 ? 171 LYS A CA    1 
ATOM   1013 C C     . LYS A 1 171 ? 88.747  103.880 114.077 1.00 492.51 ? 171 LYS A C     1 
ATOM   1014 O O     . LYS A 1 171 ? 87.981  104.276 113.190 1.00 492.51 ? 171 LYS A O     1 
ATOM   1015 C CB    . LYS A 1 171 ? 87.886  101.703 115.001 1.00 492.51 ? 171 LYS A CB    1 
ATOM   1016 C CG    . LYS A 1 171 ? 88.005  100.188 114.979 1.00 492.51 ? 171 LYS A CG    1 
ATOM   1017 C CD    . LYS A 1 171 ? 86.807  99.507  115.611 1.00 492.51 ? 171 LYS A CD    1 
ATOM   1018 C CE    . LYS A 1 171 ? 86.983  97.998  115.604 1.00 492.51 ? 171 LYS A CE    1 
ATOM   1019 N NZ    . LYS A 1 171 ? 85.807  97.302  116.185 1.00 492.51 ? 171 LYS A NZ    1 
ATOM   1020 N N     . ASN A 1 172 ? 89.376  104.709 114.913 1.00 594.07 ? 172 ASN A N     1 
ATOM   1021 C CA    . ASN A 1 172 ? 89.226  106.164 114.870 1.00 594.07 ? 172 ASN A CA    1 
ATOM   1022 C C     . ASN A 1 172 ? 87.753  106.556 114.958 1.00 594.07 ? 172 ASN A C     1 
ATOM   1023 O O     . ASN A 1 172 ? 87.285  107.490 114.303 1.00 594.07 ? 172 ASN A O     1 
ATOM   1024 C CB    . ASN A 1 172 ? 89.886  106.748 113.619 1.00 594.07 ? 172 ASN A CB    1 
ATOM   1025 C CG    . ASN A 1 172 ? 91.342  106.344 113.484 1.00 594.07 ? 172 ASN A CG    1 
ATOM   1026 O OD1   . ASN A 1 172 ? 92.215  106.889 114.160 1.00 594.07 ? 172 ASN A OD1   1 
ATOM   1027 N ND2   . ASN A 1 172 ? 91.611  105.382 112.608 1.00 594.07 ? 172 ASN A ND2   1 
ATOM   1028 N N     . MET A 1 173 ? 87.021  105.823 115.790 1.00 654.71 ? 173 MET A N     1 
ATOM   1029 C CA    . MET A 1 173 ? 85.631  106.141 116.084 1.00 654.71 ? 173 MET A CA    1 
ATOM   1030 C C     . MET A 1 173 ? 85.529  107.029 117.319 1.00 654.71 ? 173 MET A C     1 
ATOM   1031 O O     . MET A 1 173 ? 86.387  107.882 117.554 1.00 654.71 ? 173 MET A O     1 
ATOM   1032 C CB    . MET A 1 173 ? 84.822  104.857 116.284 1.00 654.71 ? 173 MET A CB    1 
ATOM   1033 C CG    . MET A 1 173 ? 84.903  103.889 115.110 1.00 654.71 ? 173 MET A CG    1 
ATOM   1034 S SD    . MET A 1 173 ? 83.990  102.358 115.390 1.00 654.71 ? 173 MET A SD    1 
ATOM   1035 C CE    . MET A 1 173 ? 82.331  102.988 115.652 1.00 654.71 ? 173 MET A CE    1 
ATOM   1036 N N     . GLN A 1 208 ? 92.000  126.837 136.834 1.00 763.51 ? 208 GLN A N     1 
ATOM   1037 C CA    . GLN A 1 208 ? 93.162  126.114 136.329 1.00 763.51 ? 208 GLN A CA    1 
ATOM   1038 C C     . GLN A 1 208 ? 93.551  124.962 137.248 1.00 763.51 ? 208 GLN A C     1 
ATOM   1039 O O     . GLN A 1 208 ? 93.993  123.908 136.789 1.00 763.51 ? 208 GLN A O     1 
ATOM   1040 C CB    . GLN A 1 208 ? 94.353  127.062 136.156 1.00 763.51 ? 208 GLN A CB    1 
ATOM   1041 C CG    . GLN A 1 208 ? 94.188  128.084 135.046 1.00 763.51 ? 208 GLN A CG    1 
ATOM   1042 C CD    . GLN A 1 208 ? 95.367  129.036 134.955 1.00 763.51 ? 208 GLN A CD    1 
ATOM   1043 O OE1   . GLN A 1 208 ? 95.581  129.866 135.838 1.00 763.51 ? 208 GLN A OE1   1 
ATOM   1044 N NE2   . GLN A 1 208 ? 96.146  128.912 133.886 1.00 763.51 ? 208 GLN A NE2   1 
ATOM   1045 N N     . LEU A 1 209 ? 93.394  125.178 138.556 1.00 691.94 ? 209 LEU A N     1 
ATOM   1046 C CA    . LEU A 1 209 ? 93.830  124.184 139.529 1.00 691.94 ? 209 LEU A CA    1 
ATOM   1047 C C     . LEU A 1 209 ? 92.827  123.042 139.662 1.00 691.94 ? 209 LEU A C     1 
ATOM   1048 O O     . LEU A 1 209 ? 93.223  121.878 139.789 1.00 691.94 ? 209 LEU A O     1 
ATOM   1049 C CB    . LEU A 1 209 ? 94.063  124.857 140.882 1.00 691.94 ? 209 LEU A CB    1 
ATOM   1050 C CG    . LEU A 1 209 ? 95.310  125.743 140.976 1.00 691.94 ? 209 LEU A CG    1 
ATOM   1051 C CD1   . LEU A 1 209 ? 95.298  126.569 142.252 1.00 691.94 ? 209 LEU A CD1   1 
ATOM   1052 C CD2   . LEU A 1 209 ? 96.563  124.891 140.909 1.00 691.94 ? 209 LEU A CD2   1 
ATOM   1053 N N     . PHE A 1 210 ? 91.527  123.352 139.649 1.00 715.26 ? 210 PHE A N     1 
ATOM   1054 C CA    . PHE A 1 210 ? 90.512  122.300 139.635 1.00 715.26 ? 210 PHE A CA    1 
ATOM   1055 C C     . PHE A 1 210 ? 90.643  121.402 138.407 1.00 715.26 ? 210 PHE A C     1 
ATOM   1056 O O     . PHE A 1 210 ? 90.437  120.186 138.492 1.00 715.26 ? 210 PHE A O     1 
ATOM   1057 C CB    . PHE A 1 210 ? 89.115  122.920 139.688 1.00 715.26 ? 210 PHE A CB    1 
ATOM   1058 C CG    . PHE A 1 210 ? 88.782  123.579 140.999 1.00 715.26 ? 210 PHE A CG    1 
ATOM   1059 C CD1   . PHE A 1 210 ? 89.122  122.981 142.202 1.00 715.26 ? 210 PHE A CD1   1 
ATOM   1060 C CD2   . PHE A 1 210 ? 88.124  124.798 141.027 1.00 715.26 ? 210 PHE A CD2   1 
ATOM   1061 C CE1   . PHE A 1 210 ? 88.810  123.587 143.406 1.00 715.26 ? 210 PHE A CE1   1 
ATOM   1062 C CE2   . PHE A 1 210 ? 87.813  125.411 142.226 1.00 715.26 ? 210 PHE A CE2   1 
ATOM   1063 C CZ    . PHE A 1 210 ? 88.157  124.805 143.418 1.00 715.26 ? 210 PHE A CZ    1 
ATOM   1064 N N     . TYR A 1 211 ? 91.051  121.976 137.274 1.00 658.71 ? 211 TYR A N     1 
ATOM   1065 C CA    . TYR A 1 211 ? 91.281  121.173 136.075 1.00 658.71 ? 211 TYR A CA    1 
ATOM   1066 C C     . TYR A 1 211 ? 92.517  120.299 136.232 1.00 658.71 ? 211 TYR A C     1 
ATOM   1067 O O     . TYR A 1 211 ? 92.502  119.111 135.888 1.00 658.71 ? 211 TYR A O     1 
ATOM   1068 C CB    . TYR A 1 211 ? 91.415  122.096 134.862 1.00 658.71 ? 211 TYR A CB    1 
ATOM   1069 C CG    . TYR A 1 211 ? 91.876  121.430 133.582 1.00 658.71 ? 211 TYR A CG    1 
ATOM   1070 C CD1   . TYR A 1 211 ? 91.014  120.629 132.841 1.00 658.71 ? 211 TYR A CD1   1 
ATOM   1071 C CD2   . TYR A 1 211 ? 93.169  121.611 133.108 1.00 658.71 ? 211 TYR A CD2   1 
ATOM   1072 C CE1   . TYR A 1 211 ? 91.431  120.025 131.668 1.00 658.71 ? 211 TYR A CE1   1 
ATOM   1073 C CE2   . TYR A 1 211 ? 93.595  121.011 131.940 1.00 658.71 ? 211 TYR A CE2   1 
ATOM   1074 C CZ    . TYR A 1 211 ? 92.723  120.221 131.223 1.00 658.71 ? 211 TYR A CZ    1 
ATOM   1075 O OH    . TYR A 1 211 ? 93.154  119.627 130.056 1.00 658.71 ? 211 TYR A OH    1 
ATOM   1076 N N     . ALA A 1 212 ? 93.592  120.865 136.783 1.00 566.48 ? 212 ALA A N     1 
ATOM   1077 C CA    . ALA A 1 212 ? 94.816  120.099 136.982 1.00 566.48 ? 212 ALA A CA    1 
ATOM   1078 C C     . ALA A 1 212 ? 94.609  118.983 138.000 1.00 566.48 ? 212 ALA A C     1 
ATOM   1079 O O     . ALA A 1 212 ? 95.140  117.877 137.836 1.00 566.48 ? 212 ALA A O     1 
ATOM   1080 C CB    . ALA A 1 212 ? 95.933  121.042 137.429 1.00 566.48 ? 212 ALA A CB    1 
ATOM   1081 N N     . ALA A 1 213 ? 93.667  119.183 138.921 1.00 525.32 ? 213 ALA A N     1 
ATOM   1082 C CA    . ALA A 1 213 ? 93.362  118.169 139.925 1.00 525.32 ? 213 ALA A CA    1 
ATOM   1083 C C     . ALA A 1 213 ? 92.493  117.070 139.340 1.00 525.32 ? 213 ALA A C     1 
ATOM   1084 O O     . ALA A 1 213 ? 92.762  115.881 139.553 1.00 525.32 ? 213 ALA A O     1 
ATOM   1085 C CB    . ALA A 1 213 ? 92.682  118.812 141.131 1.00 525.32 ? 213 ALA A CB    1 
ATOM   1086 N N     . ARG A 1 214 ? 91.450  117.436 138.598 1.00 558.39 ? 214 ARG A N     1 
ATOM   1087 C CA    . ARG A 1 214 ? 90.579  116.399 138.071 1.00 558.39 ? 214 ARG A CA    1 
ATOM   1088 C C     . ARG A 1 214 ? 91.300  115.597 136.997 1.00 558.39 ? 214 ARG A C     1 
ATOM   1089 O O     . ARG A 1 214 ? 91.082  114.387 136.884 1.00 558.39 ? 214 ARG A O     1 
ATOM   1090 C CB    . ARG A 1 214 ? 89.294  117.012 137.516 1.00 558.39 ? 214 ARG A CB    1 
ATOM   1091 C CG    . ARG A 1 214 ? 88.315  117.496 138.580 1.00 558.39 ? 214 ARG A CG    1 
ATOM   1092 C CD    . ARG A 1 214 ? 87.322  118.493 137.991 1.00 558.39 ? 214 ARG A CD    1 
ATOM   1093 N NE    . ARG A 1 214 ? 86.602  117.941 136.850 1.00 558.39 ? 214 ARG A NE    1 
ATOM   1094 C CZ    . ARG A 1 214 ? 85.577  117.104 136.938 1.00 558.39 ? 214 ARG A CZ    1 
ATOM   1095 N NH1   . ARG A 1 214 ? 84.989  116.680 135.822 1.00 558.39 ? 214 ARG A NH1   1 
ATOM   1096 N NH2   . ARG A 1 214 ? 85.144  116.661 138.106 1.00 558.39 ? 214 ARG A NH2   1 
ATOM   1097 N N     . ASP A 1 215 ? 92.206  116.231 136.244 1.00 477.71 ? 215 ASP A N     1 
ATOM   1098 C CA    . ASP A 1 215 ? 92.960  115.500 135.231 1.00 477.71 ? 215 ASP A CA    1 
ATOM   1099 C C     . ASP A 1 215 ? 94.058  114.653 135.862 1.00 477.71 ? 215 ASP A C     1 
ATOM   1100 O O     . ASP A 1 215 ? 94.457  113.628 135.298 1.00 477.71 ? 215 ASP A O     1 
ATOM   1101 C CB    . ASP A 1 215 ? 93.559  116.467 134.213 1.00 477.71 ? 215 ASP A CB    1 
ATOM   1102 C CG    . ASP A 1 215 ? 92.675  116.660 133.004 1.00 477.71 ? 215 ASP A CG    1 
ATOM   1103 O OD1   . ASP A 1 215 ? 91.604  116.021 132.940 1.00 477.71 ? 215 ASP A OD1   1 
ATOM   1104 O OD2   . ASP A 1 215 ? 93.062  117.438 132.111 1.00 477.71 ? 215 ASP A OD2   1 
ATOM   1105 N N     . SER A 1 216 ? 94.578  115.071 137.021 1.00 417.38 ? 216 SER A N     1 
ATOM   1106 C CA    . SER A 1 216 ? 95.516  114.217 137.734 1.00 417.38 ? 216 SER A CA    1 
ATOM   1107 C C     . SER A 1 216 ? 94.830  113.014 138.366 1.00 417.38 ? 216 SER A C     1 
ATOM   1108 O O     . SER A 1 216 ? 95.419  111.928 138.420 1.00 417.38 ? 216 SER A O     1 
ATOM   1109 C CB    . SER A 1 216 ? 96.239  115.025 138.811 1.00 417.38 ? 216 SER A CB    1 
ATOM   1110 O OG    . SER A 1 216 ? 95.303  115.639 139.675 1.00 417.38 ? 216 SER A OG    1 
ATOM   1111 N N     . SER A 1 217 ? 93.598  113.184 138.848 1.00 432.04 ? 217 SER A N     1 
ATOM   1112 C CA    . SER A 1 217 ? 92.963  112.117 139.612 1.00 432.04 ? 217 SER A CA    1 
ATOM   1113 C C     . SER A 1 217 ? 92.161  111.165 138.728 1.00 432.04 ? 217 SER A C     1 
ATOM   1114 O O     . SER A 1 217 ? 91.998  109.991 139.080 1.00 432.04 ? 217 SER A O     1 
ATOM   1115 C CB    . SER A 1 217 ? 92.085  112.718 140.707 1.00 432.04 ? 217 SER A CB    1 
ATOM   1116 O OG    . SER A 1 217 ? 90.966  113.385 140.160 1.00 432.04 ? 217 SER A OG    1 
ATOM   1117 N N     . CYS A 1 218 ? 91.639  111.641 137.591 1.00 438.18 ? 218 CYS A N     1 
ATOM   1118 C CA    . CYS A 1 218 ? 90.963  110.748 136.654 1.00 438.18 ? 218 CYS A CA    1 
ATOM   1119 C C     . CYS A 1 218 ? 91.883  109.633 136.181 1.00 438.18 ? 218 CYS A C     1 
ATOM   1120 O O     . CYS A 1 218 ? 91.404  108.562 135.782 1.00 438.18 ? 218 CYS A O     1 
ATOM   1121 C CB    . CYS A 1 218 ? 90.436  111.532 135.452 1.00 438.18 ? 218 CYS A CB    1 
ATOM   1122 S SG    . CYS A 1 218 ? 91.720  112.227 134.387 1.00 438.18 ? 218 CYS A SG    1 
ATOM   1123 N N     . LEU A 1 219 ? 93.194  109.884 136.190 1.00 404.98 ? 219 LEU A N     1 
ATOM   1124 C CA    . LEU A 1 219 ? 94.158  108.873 135.785 1.00 404.98 ? 219 LEU A CA    1 
ATOM   1125 C C     . LEU A 1 219 ? 94.084  107.636 136.667 1.00 404.98 ? 219 LEU A C     1 
ATOM   1126 O O     . LEU A 1 219 ? 94.321  106.528 136.186 1.00 404.98 ? 219 LEU A O     1 
ATOM   1127 C CB    . LEU A 1 219 ? 95.562  109.471 135.807 1.00 404.98 ? 219 LEU A CB    1 
ATOM   1128 C CG    . LEU A 1 219 ? 95.748  110.671 134.880 1.00 404.98 ? 219 LEU A CG    1 
ATOM   1129 C CD1   . LEU A 1 219 ? 97.068  111.366 135.155 1.00 404.98 ? 219 LEU A CD1   1 
ATOM   1130 C CD2   . LEU A 1 219 ? 95.658  110.233 133.427 1.00 404.98 ? 219 LEU A CD2   1 
ATOM   1131 N N     . LEU A 1 220 ? 93.762  107.797 137.952 1.00 406.48 ? 220 LEU A N     1 
ATOM   1132 C CA    . LEU A 1 220 ? 93.641  106.636 138.833 1.00 406.48 ? 220 LEU A CA    1 
ATOM   1133 C C     . LEU A 1 220 ? 92.539  105.694 138.361 1.00 406.48 ? 220 LEU A C     1 
ATOM   1134 O O     . LEU A 1 220 ? 92.732  104.468 138.300 1.00 406.48 ? 220 LEU A O     1 
ATOM   1135 C CB    . LEU A 1 220 ? 93.374  107.098 140.264 1.00 406.48 ? 220 LEU A CB    1 
ATOM   1136 C CG    . LEU A 1 220 ? 94.495  107.872 140.961 1.00 406.48 ? 220 LEU A CG    1 
ATOM   1137 C CD1   . LEU A 1 220 ? 94.004  108.453 142.276 1.00 406.48 ? 220 LEU A CD1   1 
ATOM   1138 C CD2   . LEU A 1 220 ? 95.693  106.974 141.195 1.00 406.48 ? 220 LEU A CD2   1 
ATOM   1139 N N     . LYS A 1 221 ? 91.420  106.254 137.899 1.00 508.44 ? 221 LYS A N     1 
ATOM   1140 C CA    . LYS A 1 221 ? 90.312  105.414 137.463 1.00 508.44 ? 221 LYS A CA    1 
ATOM   1141 C C     . LYS A 1 221 ? 90.553  104.895 136.057 1.00 508.44 ? 221 LYS A C     1 
ATOM   1142 O O     . LYS A 1 221 ? 90.149  103.770 135.725 1.00 508.44 ? 221 LYS A O     1 
ATOM   1143 C CB    . LYS A 1 221 ? 89.000  106.195 137.537 1.00 508.44 ? 221 LYS A CB    1 
ATOM   1144 C CG    . LYS A 1 221 ? 88.631  106.650 138.937 1.00 508.44 ? 221 LYS A CG    1 
ATOM   1145 C CD    . LYS A 1 221 ? 87.198  107.155 138.995 1.00 508.44 ? 221 LYS A CD    1 
ATOM   1146 C CE    . LYS A 1 221 ? 86.754  107.384 140.430 1.00 508.44 ? 221 LYS A CE    1 
ATOM   1147 N NZ    . LYS A 1 221 ? 86.776  106.122 141.220 1.00 508.44 ? 221 LYS A NZ    1 
ATOM   1148 N N     . LEU A 1 222 ? 91.275  105.660 135.235 1.00 442.99 ? 222 LEU A N     1 
ATOM   1149 C CA    . LEU A 1 222 ? 91.630  105.117 133.933 1.00 442.99 ? 222 LEU A CA    1 
ATOM   1150 C C     . LEU A 1 222 ? 92.586  103.950 134.127 1.00 442.99 ? 222 LEU A C     1 
ATOM   1151 O O     . LEU A 1 222 ? 92.515  102.949 133.409 1.00 442.99 ? 222 LEU A O     1 
ATOM   1152 C CB    . LEU A 1 222 ? 92.254  106.201 133.054 1.00 442.99 ? 222 LEU A CB    1 
ATOM   1153 C CG    . LEU A 1 222 ? 91.314  107.271 132.494 1.00 442.99 ? 222 LEU A CG    1 
ATOM   1154 C CD1   . LEU A 1 222 ? 92.103  108.350 131.765 1.00 442.99 ? 222 LEU A CD1   1 
ATOM   1155 C CD2   . LEU A 1 222 ? 90.274  106.651 131.574 1.00 442.99 ? 222 LEU A CD2   1 
ATOM   1156 N N     . TYR A 1 223 ? 93.492  104.072 135.102 1.00 434.39 ? 223 TYR A N     1 
ATOM   1157 C CA    . TYR A 1 223 ? 94.459  103.023 135.390 1.00 434.39 ? 223 TYR A CA    1 
ATOM   1158 C C     . TYR A 1 223 ? 93.729  101.760 135.808 1.00 434.39 ? 223 TYR A C     1 
ATOM   1159 O O     . TYR A 1 223 ? 94.049  100.658 135.357 1.00 434.39 ? 223 TYR A O     1 
ATOM   1160 C CB    . TYR A 1 223 ? 95.428  103.471 136.476 1.00 434.39 ? 223 TYR A CB    1 
ATOM   1161 C CG    . TYR A 1 223 ? 96.293  102.353 137.002 1.00 434.39 ? 223 TYR A CG    1 
ATOM   1162 C CD1   . TYR A 1 223 ? 97.277  101.785 136.205 1.00 434.39 ? 223 TYR A CD1   1 
ATOM   1163 C CD2   . TYR A 1 223 ? 96.131  101.868 138.291 1.00 434.39 ? 223 TYR A CD2   1 
ATOM   1164 C CE1   . TYR A 1 223 ? 98.071  100.761 136.674 1.00 434.39 ? 223 TYR A CE1   1 
ATOM   1165 C CE2   . TYR A 1 223 ? 96.923  100.842 138.770 1.00 434.39 ? 223 TYR A CE2   1 
ATOM   1166 C CZ    . TYR A 1 223 ? 97.892  100.294 137.957 1.00 434.39 ? 223 TYR A CZ    1 
ATOM   1167 O OH    . TYR A 1 223 ? 98.685  99.273  138.427 1.00 434.39 ? 223 TYR A OH    1 
ATOM   1168 N N     . LYS A 1 224 ? 92.748  101.916 136.703 1.00 504.83 ? 224 LYS A N     1 
ATOM   1169 C CA    . LYS A 1 224 ? 91.969  100.776 137.182 1.00 504.83 ? 224 LYS A CA    1 
ATOM   1170 C C     . LYS A 1 224 ? 91.242  100.093 136.030 1.00 504.83 ? 224 LYS A C     1 
ATOM   1171 O O     . LYS A 1 224 ? 91.309  98.865  135.881 1.00 504.83 ? 224 LYS A O     1 
ATOM   1172 C CB    . LYS A 1 224 ? 90.982  101.224 138.260 1.00 504.83 ? 224 LYS A CB    1 
ATOM   1173 C CG    . LYS A 1 224 ? 91.646  101.803 139.493 1.00 504.83 ? 224 LYS A CG    1 
ATOM   1174 C CD    . LYS A 1 224 ? 90.698  102.691 140.274 1.00 504.83 ? 224 LYS A CD    1 
ATOM   1175 C CE    . LYS A 1 224 ? 91.454  103.472 141.333 1.00 504.83 ? 224 LYS A CE    1 
ATOM   1176 N NZ    . LYS A 1 224 ? 90.586  104.443 142.046 1.00 504.83 ? 224 LYS A NZ    1 
ATOM   1177 N N     . LYS A 1 225 ? 90.529  100.853 135.184 1.00 527.46 ? 225 LYS A N     1 
ATOM   1178 C CA    . LYS A 1 225 ? 89.733  100.260 134.095 1.00 527.46 ? 225 LYS A CA    1 
ATOM   1179 C C     . LYS A 1 225 ? 90.600  99.759  132.943 1.00 527.46 ? 225 LYS A C     1 
ATOM   1180 O O     . LYS A 1 225 ? 90.484  98.605  132.558 1.00 527.46 ? 225 LYS A O     1 
ATOM   1181 C CB    . LYS A 1 225 ? 88.638  101.231 133.621 1.00 527.46 ? 225 LYS A CB    1 
ATOM   1182 C CG    . LYS A 1 225 ? 87.642  100.579 132.643 1.00 527.46 ? 225 LYS A CG    1 
ATOM   1183 C CD    . LYS A 1 225 ? 86.952  99.341  133.240 1.00 527.46 ? 225 LYS A CD    1 
ATOM   1184 C CE    . LYS A 1 225 ? 85.843  98.813  132.328 1.00 527.46 ? 225 LYS A CE    1 
ATOM   1185 N NZ    . LYS A 1 225 ? 85.122  97.680  132.960 1.00 527.46 ? 225 LYS A NZ    1 
ATOM   1186 N N     . LEU A 1 226 ? 91.536  100.564 132.442 1.00 483.01 ? 226 LEU A N     1 
ATOM   1187 C CA    . LEU A 1 226 ? 92.468  100.167 131.378 1.00 483.01 ? 226 LEU A CA    1 
ATOM   1188 C C     . LEU A 1 226 ? 93.346  98.979  131.792 1.00 483.01 ? 226 LEU A C     1 
ATOM   1189 O O     . LEU A 1 226 ? 93.815  98.261  130.915 1.00 483.01 ? 226 LEU A O     1 
ATOM   1190 C CB    . LEU A 1 226 ? 93.329  101.367 130.931 1.00 483.01 ? 226 LEU A CB    1 
ATOM   1191 C CG    . LEU A 1 226 ? 92.520  102.535 130.328 1.00 483.01 ? 226 LEU A CG    1 
ATOM   1192 C CD1   . LEU A 1 226 ? 93.336  103.824 130.329 1.00 483.01 ? 226 LEU A CD1   1 
ATOM   1193 C CD2   . LEU A 1 226 ? 92.107  102.245 128.889 1.00 483.01 ? 226 LEU A CD2   1 
ATOM   1194 N N     . LYS A 1 227 ? 93.531  98.731  133.098 1.00 532.08 ? 227 LYS A N     1 
ATOM   1195 C CA    . LYS A 1 227 ? 94.181  97.522  133.618 1.00 532.08 ? 227 LYS A CA    1 
ATOM   1196 C C     . LYS A 1 227 ? 93.243  96.331  133.847 1.00 532.08 ? 227 LYS A C     1 
ATOM   1197 O O     . LYS A 1 227 ? 93.730  95.204  133.875 1.00 532.08 ? 227 LYS A O     1 
ATOM   1198 C CB    . LYS A 1 227 ? 95.048  97.886  134.828 1.00 532.08 ? 227 LYS A CB    1 
ATOM   1199 C CG    . LYS A 1 227 ? 96.106  96.818  135.129 1.00 532.08 ? 227 LYS A CG    1 
ATOM   1200 C CD    . LYS A 1 227 ? 97.297  97.434  135.865 1.00 532.08 ? 227 LYS A CD    1 
ATOM   1201 C CE    . LYS A 1 227 ? 98.386  96.380  136.078 1.00 532.08 ? 227 LYS A CE    1 
ATOM   1202 N NZ    . LYS A 1 227 ? 99.635  96.984  136.608 1.00 532.08 ? 227 LYS A NZ    1 
ATOM   1203 N N     . GLU A 1 228 ? 91.915  96.502  133.877 1.00 540.69 ? 228 GLU A N     1 
ATOM   1204 C CA    . GLU A 1 228 ? 91.052  95.382  133.469 1.00 540.69 ? 228 GLU A CA    1 
ATOM   1205 C C     . GLU A 1 228 ? 91.406  95.054  132.022 1.00 540.69 ? 228 GLU A C     1 
ATOM   1206 O O     . GLU A 1 228 ? 91.775  93.926  131.713 1.00 540.69 ? 228 GLU A O     1 
ATOM   1207 C CB    . GLU A 1 228 ? 89.539  95.676  133.520 1.00 540.69 ? 228 GLU A CB    1 
ATOM   1208 C CG    . GLU A 1 228 ? 88.940  95.850  134.918 1.00 540.69 ? 228 GLU A CG    1 
ATOM   1209 C CD    . GLU A 1 228 ? 87.420  96.115  134.872 1.00 540.69 ? 228 GLU A CD    1 
ATOM   1210 O OE1   . GLU A 1 228 ? 86.699  95.560  134.008 1.00 540.69 ? 228 GLU A OE1   1 
ATOM   1211 O OE2   . GLU A 1 228 ? 86.926  96.906  135.705 1.00 540.69 ? 228 GLU A OE2   1 
ATOM   1212 N N     . GLU A 1 229 ? 91.432  96.075  131.163 1.00 489.47 ? 229 GLU A N     1 
ATOM   1213 C CA    . GLU A 1 229 ? 91.709  95.875  129.745 1.00 489.47 ? 229 GLU A CA    1 
ATOM   1214 C C     . GLU A 1 229 ? 93.153  95.448  129.438 1.00 489.47 ? 229 GLU A C     1 
ATOM   1215 O O     . GLU A 1 229 ? 93.509  95.190  128.287 1.00 489.47 ? 229 GLU A O     1 
ATOM   1216 C CB    . GLU A 1 229 ? 91.300  97.089  128.898 1.00 489.47 ? 229 GLU A CB    1 
ATOM   1217 C CG    . GLU A 1 229 ? 90.023  97.869  129.269 1.00 489.47 ? 229 GLU A CG    1 
ATOM   1218 C CD    . GLU A 1 229 ? 88.745  97.068  129.573 1.00 489.47 ? 229 GLU A CD    1 
ATOM   1219 O OE1   . GLU A 1 229 ? 88.745  95.824  129.518 1.00 489.47 ? 229 GLU A OE1   1 
ATOM   1220 O OE2   . GLU A 1 229 ? 87.705  97.718  129.833 1.00 489.47 ? 229 GLU A OE2   1 
ATOM   1221 N N     . ILE A 1 230 ? 94.006  95.369  130.460 1.00 418.76 ? 230 ILE A N     1 
ATOM   1222 C CA    . ILE A 1 230 ? 95.142  94.459  130.466 1.00 418.76 ? 230 ILE A CA    1 
ATOM   1223 C C     . ILE A 1 230 ? 94.555  93.044  130.649 1.00 418.76 ? 230 ILE A C     1 
ATOM   1224 O O     . ILE A 1 230 ? 93.902  92.526  129.741 1.00 418.76 ? 230 ILE A O     1 
ATOM   1225 C CB    . ILE A 1 230 ? 96.217  94.915  131.487 1.00 418.76 ? 230 ILE A CB    1 
ATOM   1226 C CG1   . ILE A 1 230 ? 96.770  96.314  131.140 1.00 418.76 ? 230 ILE A CG1   1 
ATOM   1227 C CG2   . ILE A 1 230 ? 97.414  93.965  131.631 1.00 418.76 ? 230 ILE A CG2   1 
ATOM   1228 C CD1   . ILE A 1 230 ? 97.758  96.326  129.980 1.00 418.76 ? 230 ILE A CD1   1 
ATOM   1229 N N     . LYS A 1 231 ? 94.724  92.409  131.811 1.00 466.37 ? 231 LYS A N     1 
ATOM   1230 C CA    . LYS A 1 231 ? 94.628  90.946  131.971 1.00 466.37 ? 231 LYS A CA    1 
ATOM   1231 C C     . LYS A 1 231 ? 93.278  90.328  131.588 1.00 466.37 ? 231 LYS A C     1 
ATOM   1232 O O     . LYS A 1 231 ? 93.236  89.172  131.165 1.00 466.37 ? 231 LYS A O     1 
ATOM   1233 C CB    . LYS A 1 231 ? 95.013  90.598  133.415 1.00 466.37 ? 231 LYS A CB    1 
ATOM   1234 C CG    . LYS A 1 231 ? 95.189  89.085  133.609 1.00 466.37 ? 231 LYS A CG    1 
ATOM   1235 C CD    . LYS A 1 231 ? 95.755  88.768  134.995 1.00 466.37 ? 231 LYS A CD    1 
ATOM   1236 C CE    . LYS A 1 231 ? 95.896  87.252  135.145 1.00 466.37 ? 231 LYS A CE    1 
ATOM   1237 N NZ    . LYS A 1 231 ? 96.420  86.884  136.481 1.00 466.37 ? 231 LYS A NZ    1 
ATOM   1238 N N     . LYS A 1 232 ? 92.182  91.077  131.706 1.00 529.41 ? 232 LYS A N     1 
ATOM   1239 C CA    . LYS A 1 232 ? 90.819  90.601  131.427 1.00 529.41 ? 232 LYS A CA    1 
ATOM   1240 C C     . LYS A 1 232 ? 90.586  90.299  129.942 1.00 529.41 ? 232 LYS A C     1 
ATOM   1241 O O     . LYS A 1 232 ? 89.754  89.457  129.614 1.00 529.41 ? 232 LYS A O     1 
ATOM   1242 C CB    . LYS A 1 232 ? 89.845  91.681  131.926 1.00 529.41 ? 232 LYS A CB    1 
ATOM   1243 C CG    . LYS A 1 232 ? 88.402  91.221  132.150 1.00 529.41 ? 232 LYS A CG    1 
ATOM   1244 C CD    . LYS A 1 232 ? 87.586  92.440  132.596 1.00 529.41 ? 232 LYS A CD    1 
ATOM   1245 C CE    . LYS A 1 232 ? 86.143  92.079  132.934 1.00 529.41 ? 232 LYS A CE    1 
ATOM   1246 N NZ    . LYS A 1 232 ? 85.324  93.303  133.103 1.00 529.41 ? 232 LYS A NZ    1 
ATOM   1247 N N     . GLU A 1 233 ? 91.290  90.988  129.041 1.00 480.66 ? 233 GLU A N     1 
ATOM   1248 C CA    . GLU A 1 233 ? 90.835  91.139  127.649 1.00 480.66 ? 233 GLU A CA    1 
ATOM   1249 C C     . GLU A 1 233 ? 91.449  90.211  126.589 1.00 480.66 ? 233 GLU A C     1 
ATOM   1250 O O     . GLU A 1 233 ? 90.961  90.211  125.460 1.00 480.66 ? 233 GLU A O     1 
ATOM   1251 C CB    . GLU A 1 233 ? 91.064  92.596  127.218 1.00 480.66 ? 233 GLU A CB    1 
ATOM   1252 C CG    . GLU A 1 233 ? 90.017  93.555  127.769 1.00 480.66 ? 233 GLU A CG    1 
ATOM   1253 C CD    . GLU A 1 233 ? 88.659  93.362  127.090 1.00 480.66 ? 233 GLU A CD    1 
ATOM   1254 O OE1   . GLU A 1 233 ? 88.439  93.930  125.996 1.00 480.66 ? 233 GLU A OE1   1 
ATOM   1255 O OE2   . GLU A 1 233 ? 87.825  92.590  127.616 1.00 480.66 ? 233 GLU A OE2   1 
ATOM   1256 N N     . ASN A 1 234 ? 92.539  89.482  126.862 1.00 449.34 ? 234 ASN A N     1 
ATOM   1257 C CA    . ASN A 1 234 ? 93.485  88.947  125.846 1.00 449.34 ? 234 ASN A CA    1 
ATOM   1258 C C     . ASN A 1 234 ? 94.188  90.050  125.024 1.00 449.34 ? 234 ASN A C     1 
ATOM   1259 O O     . ASN A 1 234 ? 95.408  89.997  124.868 1.00 449.34 ? 234 ASN A O     1 
ATOM   1260 C CB    . ASN A 1 234 ? 92.853  87.868  124.939 1.00 449.34 ? 234 ASN A CB    1 
ATOM   1261 C CG    . ASN A 1 234 ? 92.271  86.700  125.708 1.00 449.34 ? 234 ASN A CG    1 
ATOM   1262 O OD1   . ASN A 1 234 ? 92.980  85.813  126.161 1.00 449.34 ? 234 ASN A OD1   1 
ATOM   1263 N ND2   . ASN A 1 234 ? 90.969  86.643  125.865 1.00 449.34 ? 234 ASN A ND2   1 
ATOM   1264 N N     . LEU A 1 235 ? 93.481  91.133  124.676 1.00 425.89 ? 235 LEU A N     1 
ATOM   1265 C CA    . LEU A 1 235 ? 94.055  92.470  124.447 1.00 425.89 ? 235 LEU A CA    1 
ATOM   1266 C C     . LEU A 1 235 ? 94.955  92.896  125.625 1.00 425.89 ? 235 LEU A C     1 
ATOM   1267 O O     . LEU A 1 235 ? 95.803  93.756  125.436 1.00 425.89 ? 235 LEU A O     1 
ATOM   1268 C CB    . LEU A 1 235 ? 92.933  93.462  124.041 1.00 425.89 ? 235 LEU A CB    1 
ATOM   1269 C CG    . LEU A 1 235 ? 92.988  94.927  124.543 1.00 425.89 ? 235 LEU A CG    1 
ATOM   1270 C CD1   . LEU A 1 235 ? 93.872  95.830  123.681 1.00 425.89 ? 235 LEU A CD1   1 
ATOM   1271 C CD2   . LEU A 1 235 ? 91.592  95.542  124.481 1.00 425.89 ? 235 LEU A CD2   1 
ATOM   1272 N N     . HIS A 1 236 ? 94.893  92.191  126.765 1.00 392.44 ? 236 HIS A N     1 
ATOM   1273 C CA    . HIS A 1 236 ? 95.997  92.039  127.711 1.00 392.44 ? 236 HIS A CA    1 
ATOM   1274 C C     . HIS A 1 236 ? 97.366  92.165  127.066 1.00 392.44 ? 236 HIS A C     1 
ATOM   1275 O O     . HIS A 1 236 ? 98.117  93.062  127.412 1.00 392.44 ? 236 HIS A O     1 
ATOM   1276 C CB    . HIS A 1 236 ? 95.941  90.653  128.383 1.00 392.44 ? 236 HIS A CB    1 
ATOM   1277 C CG    . HIS A 1 236 ? 97.213  90.396  129.147 1.00 392.44 ? 236 HIS A CG    1 
ATOM   1278 N ND1   . HIS A 1 236 ? 97.705  91.227  130.146 1.00 392.44 ? 236 HIS A ND1   1 
ATOM   1279 C CD2   . HIS A 1 236 ? 98.184  89.507  128.798 1.00 392.44 ? 236 HIS A CD2   1 
ATOM   1280 C CE1   . HIS A 1 236 ? 98.970  90.843  130.365 1.00 392.44 ? 236 HIS A CE1   1 
ATOM   1281 N NE2   . HIS A 1 236 ? 99.282  89.804  129.576 1.00 392.44 ? 236 HIS A NE2   1 
ATOM   1282 N N     . ILE A 1 237 ? 97.672  91.264  126.134 1.00 405.98 ? 237 ILE A N     1 
ATOM   1283 C CA    . ILE A 1 237 ? 99.014  91.067  125.593 1.00 405.98 ? 237 ILE A CA    1 
ATOM   1284 C C     . ILE A 1 237 ? 99.494  92.384  124.971 1.00 405.98 ? 237 ILE A C     1 
ATOM   1285 O O     . ILE A 1 237 ? 100.487 92.976  125.385 1.00 405.98 ? 237 ILE A O     1 
ATOM   1286 C CB    . ILE A 1 237 ? 98.988  89.898  124.564 1.00 405.98 ? 237 ILE A CB    1 
ATOM   1287 C CG1   . ILE A 1 237 ? 98.543  88.556  125.191 1.00 405.98 ? 237 ILE A CG1   1 
ATOM   1288 C CG2   . ILE A 1 237 ? 100.353 89.718  123.875 1.00 405.98 ? 237 ILE A CG2   1 
ATOM   1289 C CD1   . ILE A 1 237 ? 98.137  87.499  124.151 1.00 405.98 ? 237 ILE A CD1   1 
ATOM   1290 N N     . VAL A 1 238 ? 98.740  92.867  123.985 1.00 397.44 ? 238 VAL A N     1 
ATOM   1291 C CA    . VAL A 1 238 ? 99.061  94.068  123.215 1.00 397.44 ? 238 VAL A CA    1 
ATOM   1292 C C     . VAL A 1 238 ? 98.978  95.322  124.078 1.00 397.44 ? 238 VAL A C     1 
ATOM   1293 O O     . VAL A 1 238 ? 99.887  96.139  124.023 1.00 397.44 ? 238 VAL A O     1 
ATOM   1294 C CB    . VAL A 1 238 ? 98.214  94.142  121.918 1.00 397.44 ? 238 VAL A CB    1 
ATOM   1295 C CG1   . VAL A 1 238 ? 96.817  93.515  122.019 1.00 397.44 ? 238 VAL A CG1   1 
ATOM   1296 C CG2   . VAL A 1 238 ? 98.024  95.571  121.409 1.00 397.44 ? 238 VAL A CG2   1 
ATOM   1297 N N     . ASN A 1 239 ? 97.937  95.479  124.895 1.00 379.98 ? 239 ASN A N     1 
ATOM   1298 C CA    . ASN A 1 239 ? 97.809  96.620  125.786 1.00 379.98 ? 239 ASN A CA    1 
ATOM   1299 C C     . ASN A 1 239 ? 99.019  96.666  126.725 1.00 379.98 ? 239 ASN A C     1 
ATOM   1300 O O     . ASN A 1 239 ? 99.716  97.665  126.778 1.00 379.98 ? 239 ASN A O     1 
ATOM   1301 C CB    . ASN A 1 239 ? 96.457  96.508  126.506 1.00 379.98 ? 239 ASN A CB    1 
ATOM   1302 C CG    . ASN A 1 239 ? 96.087  97.699  127.363 1.00 379.98 ? 239 ASN A CG    1 
ATOM   1303 O OD1   . ASN A 1 239 ? 96.612  98.791  127.252 1.00 379.98 ? 239 ASN A OD1   1 
ATOM   1304 N ND2   . ASN A 1 239 ? 95.140  97.511  128.242 1.00 379.98 ? 239 ASN A ND2   1 
ATOM   1305 N N     . ASP A 1 240 ? 99.361  95.556  127.371 1.00 306.83 ? 240 ASP A N     1 
ATOM   1306 C CA    . ASP A 1 240 ? 100.524 95.483  128.245 1.00 306.83 ? 240 ASP A CA    1 
ATOM   1307 C C     . ASP A 1 240 ? 101.813 95.790  127.487 1.00 306.83 ? 240 ASP A C     1 
ATOM   1308 O O     . ASP A 1 240 ? 102.628 96.578  127.946 1.00 306.83 ? 240 ASP A O     1 
ATOM   1309 C CB    . ASP A 1 240 ? 100.574 94.089  128.891 1.00 306.83 ? 240 ASP A CB    1 
ATOM   1310 C CG    . ASP A 1 240 ? 101.502 94.012  130.101 1.00 306.83 ? 240 ASP A CG    1 
ATOM   1311 O OD1   . ASP A 1 240 ? 101.619 95.014  130.835 1.00 306.83 ? 240 ASP A OD1   1 
ATOM   1312 O OD2   . ASP A 1 240 ? 102.091 92.932  130.343 1.00 306.83 ? 240 ASP A OD2   1 
ATOM   1313 N N     . ILE A 1 241 ? 102.006 95.223  126.300 1.00 316.22 ? 241 ILE A N     1 
ATOM   1314 C CA    . ILE A 1 241 ? 103.242 95.422  125.560 1.00 316.22 ? 241 ILE A CA    1 
ATOM   1315 C C     . ILE A 1 241 ? 103.349 96.836  125.027 1.00 316.22 ? 241 ILE A C     1 
ATOM   1316 O O     . ILE A 1 241 ? 104.358 97.457  125.327 1.00 316.22 ? 241 ILE A O     1 
ATOM   1317 C CB    . ILE A 1 241 ? 103.405 94.368  124.467 1.00 316.22 ? 241 ILE A CB    1 
ATOM   1318 C CG1   . ILE A 1 241 ? 103.660 93.020  125.171 1.00 316.22 ? 241 ILE A CG1   1 
ATOM   1319 C CG2   . ILE A 1 241 ? 104.566 94.711  123.510 1.00 316.22 ? 241 ILE A CG2   1 
ATOM   1320 C CD1   . ILE A 1 241 ? 103.534 91.824  124.225 1.00 316.22 ? 241 ILE A CD1   1 
ATOM   1321 N N     . GLU A 1 242 ? 102.359 97.379  124.299 1.00 373.28 ? 242 GLU A N     1 
ATOM   1322 C CA    . GLU A 1 242 ? 102.387 98.798  123.961 1.00 373.28 ? 242 GLU A CA    1 
ATOM   1323 C C     . GLU A 1 242 ? 102.591 99.648  125.206 1.00 373.28 ? 242 GLU A C     1 
ATOM   1324 O O     . GLU A 1 242 ? 103.343 100.631 125.182 1.00 373.28 ? 242 GLU A O     1 
ATOM   1325 C CB    . GLU A 1 242 ? 101.093 99.204  123.275 1.00 373.28 ? 242 GLU A CB    1 
ATOM   1326 C CG    . GLU A 1 242 ? 100.771 98.542  121.949 1.00 373.28 ? 242 GLU A CG    1 
ATOM   1327 C CD    . GLU A 1 242 ? 101.553 99.078  120.781 1.00 373.28 ? 242 GLU A CD    1 
ATOM   1328 O OE1   . GLU A 1 242 ? 102.316 100.053 120.952 1.00 373.28 ? 242 GLU A OE1   1 
ATOM   1329 O OE2   . GLU A 1 242 ? 101.334 98.559  119.669 1.00 373.28 ? 242 GLU A OE2   1 
ATOM   1330 N N     . ASN A 1 243 ? 101.931 99.314  126.308 1.00 315.07 ? 243 ASN A N     1 
ATOM   1331 C CA    . ASN A 1 243 ? 102.102 100.123 127.486 1.00 315.07 ? 243 ASN A CA    1 
ATOM   1332 C C     . ASN A 1 243 ? 103.533 100.006 127.969 1.00 315.07 ? 243 ASN A C     1 
ATOM   1333 O O     . ASN A 1 243 ? 104.153 101.017 128.294 1.00 315.07 ? 243 ASN A O     1 
ATOM   1334 C CB    . ASN A 1 243 ? 101.072 99.773  128.557 1.00 315.07 ? 243 ASN A CB    1 
ATOM   1335 C CG    . ASN A 1 243 ? 99.665  100.138 128.115 1.00 315.07 ? 243 ASN A CG    1 
ATOM   1336 O OD1   . ASN A 1 243 ? 99.436  100.804 127.116 1.00 315.07 ? 243 ASN A OD1   1 
ATOM   1337 N ND2   . ASN A 1 243 ? 98.676  99.730  128.872 1.00 315.07 ? 243 ASN A ND2   1 
ATOM   1338 N N     . LYS A 1 244 ? 104.142 98.821  127.917 1.00 253.68 ? 244 LYS A N     1 
ATOM   1339 C CA    . LYS A 1 244 ? 105.534 98.752  128.337 1.00 253.68 ? 244 LYS A CA    1 
ATOM   1340 C C     . LYS A 1 244 ? 106.435 99.413  127.303 1.00 253.68 ? 244 LYS A C     1 
ATOM   1341 O O     . LYS A 1 244 ? 107.571 99.783  127.617 1.00 253.68 ? 244 LYS A O     1 
ATOM   1342 C CB    . LYS A 1 244 ? 105.934 97.295  128.553 1.00 253.68 ? 244 LYS A CB    1 
ATOM   1343 C CG    . LYS A 1 244 ? 105.281 96.658  129.761 1.00 253.68 ? 244 LYS A CG    1 
ATOM   1344 C CD    . LYS A 1 244 ? 105.526 95.162  129.786 1.00 253.68 ? 244 LYS A CD    1 
ATOM   1345 C CE    . LYS A 1 244 ? 104.835 94.512  130.969 1.00 253.68 ? 244 LYS A CE    1 
ATOM   1346 N NZ    . LYS A 1 244 ? 104.883 93.027  130.882 1.00 253.68 ? 244 LYS A NZ    1 
ATOM   1347 N N     . CYS A 1 245 ? 105.931 99.557  126.075 1.00 316.06 ? 245 CYS A N     1 
ATOM   1348 C CA    . CYS A 1 245 ? 106.586 100.181 124.936 1.00 316.06 ? 245 CYS A CA    1 
ATOM   1349 C C     . CYS A 1 245 ? 106.522 101.696 124.988 1.00 316.06 ? 245 CYS A C     1 
ATOM   1350 O O     . CYS A 1 245 ? 107.155 102.355 124.157 1.00 316.06 ? 245 CYS A O     1 
ATOM   1351 C CB    . CYS A 1 245 ? 105.959 99.684  123.631 1.00 316.06 ? 245 CYS A CB    1 
ATOM   1352 S SG    . CYS A 1 245 ? 107.078 99.690  122.213 1.00 316.06 ? 245 CYS A SG    1 
ATOM   1353 N N     . ILE A 1 246 ? 105.757 102.252 125.928 1.00 260.07 ? 246 ILE A N     1 
ATOM   1354 C CA    . ILE A 1 246 ? 105.664 103.700 126.055 1.00 260.07 ? 246 ILE A CA    1 
ATOM   1355 C C     . ILE A 1 246 ? 107.054 104.281 126.252 1.00 260.07 ? 246 ILE A C     1 
ATOM   1356 O O     . ILE A 1 246 ? 107.441 105.261 125.604 1.00 260.07 ? 246 ILE A O     1 
ATOM   1357 C CB    . ILE A 1 246 ? 104.737 104.034 127.237 1.00 260.07 ? 246 ILE A CB    1 
ATOM   1358 C CG1   . ILE A 1 246 ? 103.289 103.751 126.851 1.00 260.07 ? 246 ILE A CG1   1 
ATOM   1359 C CG2   . ILE A 1 246 ? 104.903 105.486 127.646 1.00 260.07 ? 246 ILE A CG2   1 
ATOM   1360 C CD1   . ILE A 1 246 ? 102.341 103.761 128.008 1.00 260.07 ? 246 ILE A CD1   1 
ATOM   1361 N N     . LEU A 1 247 ? 107.825 103.674 127.151 1.00 287.84 ? 247 LEU A N     1 
ATOM   1362 C CA    . LEU A 1 247 ? 109.146 104.199 127.483 1.00 287.84 ? 247 LEU A CA    1 
ATOM   1363 C C     . LEU A 1 247 ? 110.108 104.074 126.305 1.00 287.84 ? 247 LEU A C     1 
ATOM   1364 O O     . LEU A 1 247 ? 110.808 105.055 125.997 1.00 287.84 ? 247 LEU A O     1 
ATOM   1365 C CB    . LEU A 1 247 ? 109.672 103.518 128.746 1.00 287.84 ? 247 LEU A CB    1 
ATOM   1366 C CG    . LEU A 1 247 ? 108.880 103.771 130.029 1.00 287.84 ? 247 LEU A CG    1 
ATOM   1367 C CD1   . LEU A 1 247 ? 109.399 102.895 131.160 1.00 287.84 ? 247 LEU A CD1   1 
ATOM   1368 C CD2   . LEU A 1 247 ? 108.937 105.240 130.412 1.00 287.84 ? 247 LEU A CD2   1 
ATOM   1369 N N     . PRO A 1 248 ? 110.218 102.919 125.626 1.00 297.10 ? 248 PRO A N     1 
ATOM   1370 C CA    . PRO A 1 248 ? 111.064 102.849 124.418 1.00 297.10 ? 248 PRO A CA    1 
ATOM   1371 C C     . PRO A 1 248 ? 110.733 103.870 123.345 1.00 297.10 ? 248 PRO A C     1 
ATOM   1372 O O     . PRO A 1 248 ? 111.651 104.357 122.674 1.00 297.10 ? 248 PRO A O     1 
ATOM   1373 C CB    . PRO A 1 248 ? 110.798 101.432 123.890 1.00 297.10 ? 248 PRO A CB    1 
ATOM   1374 C CG    . PRO A 1 248 ? 110.309 100.663 125.033 1.00 297.10 ? 248 PRO A CG    1 
ATOM   1375 C CD    . PRO A 1 248 ? 109.670 101.599 125.990 1.00 297.10 ? 248 PRO A CD    1 
ATOM   1376 N N     . ILE A 1 249 ? 109.463 104.228 123.166 1.00 328.15 ? 249 ILE A N     1 
ATOM   1377 C CA    . ILE A 1 249 ? 109.122 105.201 122.135 1.00 328.15 ? 249 ILE A CA    1 
ATOM   1378 C C     . ILE A 1 249 ? 109.621 106.585 122.528 1.00 328.15 ? 249 ILE A C     1 
ATOM   1379 O O     . ILE A 1 249 ? 110.184 107.319 121.703 1.00 328.15 ? 249 ILE A O     1 
ATOM   1380 C CB    . ILE A 1 249 ? 107.604 105.205 121.881 1.00 328.15 ? 249 ILE A CB    1 
ATOM   1381 C CG1   . ILE A 1 249 ? 107.150 103.845 121.348 1.00 328.15 ? 249 ILE A CG1   1 
ATOM   1382 C CG2   . ILE A 1 249 ? 107.225 106.314 120.913 1.00 328.15 ? 249 ILE A CG2   1 
ATOM   1383 C CD1   . ILE A 1 249 ? 105.654 103.639 121.418 1.00 328.15 ? 249 ILE A CD1   1 
ATOM   1384 N N     . CYS A 1 250 ? 109.395 106.973 123.784 1.00 368.82 ? 250 CYS A N     1 
ATOM   1385 C CA    . CYS A 1 250 ? 109.986 108.211 124.272 1.00 368.82 ? 250 CYS A CA    1 
ATOM   1386 C C     . CYS A 1 250 ? 111.498 108.200 124.098 1.00 368.82 ? 250 CYS A C     1 
ATOM   1387 O O     . CYS A 1 250 ? 112.089 109.202 123.685 1.00 368.82 ? 250 CYS A O     1 
ATOM   1388 C CB    . CYS A 1 250 ? 109.630 108.399 125.745 1.00 368.82 ? 250 CYS A CB    1 
ATOM   1389 S SG    . CYS A 1 250 ? 107.893 108.753 126.054 1.00 368.82 ? 250 CYS A SG    1 
ATOM   1390 N N     . ASP A 1 251 ? 112.141 107.072 124.416 1.00 320.41 ? 251 ASP A N     1 
ATOM   1391 C CA    . ASP A 1 251 ? 113.588 106.965 124.265 1.00 320.41 ? 251 ASP A CA    1 
ATOM   1392 C C     . ASP A 1 251 ? 114.019 107.206 122.825 1.00 320.41 ? 251 ASP A C     1 
ATOM   1393 O O     . ASP A 1 251 ? 114.959 107.968 122.563 1.00 320.41 ? 251 ASP A O     1 
ATOM   1394 C CB    . ASP A 1 251 ? 114.064 105.593 124.742 1.00 320.41 ? 251 ASP A CB    1 
ATOM   1395 C CG    . ASP A 1 251 ? 115.545 105.570 125.058 1.00 320.41 ? 251 ASP A CG    1 
ATOM   1396 O OD1   . ASP A 1 251 ? 115.999 106.421 125.850 1.00 320.41 ? 251 ASP A OD1   1 
ATOM   1397 O OD2   . ASP A 1 251 ? 116.257 104.699 124.516 1.00 320.41 ? 251 ASP A OD2   1 
ATOM   1398 N N     . MET A 1 252 ? 113.310 106.590 121.877 1.00 327.20 ? 252 MET A N     1 
ATOM   1399 C CA    . MET A 1 252 ? 113.650 106.743 120.467 1.00 327.20 ? 252 MET A CA    1 
ATOM   1400 C C     . MET A 1 252 ? 113.474 108.181 120.002 1.00 327.20 ? 252 MET A C     1 
ATOM   1401 O O     . MET A 1 252 ? 114.342 108.726 119.311 1.00 327.20 ? 252 MET A O     1 
ATOM   1402 C CB    . MET A 1 252 ? 112.788 105.796 119.634 1.00 327.20 ? 252 MET A CB    1 
ATOM   1403 C CG    . MET A 1 252 ? 112.472 106.282 118.236 1.00 327.20 ? 252 MET A CG    1 
ATOM   1404 S SD    . MET A 1 252 ? 111.894 104.939 117.190 1.00 327.20 ? 252 MET A SD    1 
ATOM   1405 C CE    . MET A 1 252 ? 110.134 105.038 117.508 1.00 327.20 ? 252 MET A CE    1 
ATOM   1406 N N     . GLU A 1 253 ? 112.360 108.815 120.371 1.00 387.08 ? 253 GLU A N     1 
ATOM   1407 C CA    . GLU A 1 253 ? 112.108 110.161 119.866 1.00 387.08 ? 253 GLU A CA    1 
ATOM   1408 C C     . GLU A 1 253 ? 113.028 111.181 120.526 1.00 387.08 ? 253 GLU A C     1 
ATOM   1409 O O     . GLU A 1 253 ? 113.457 112.147 119.882 1.00 387.08 ? 253 GLU A O     1 
ATOM   1410 C CB    . GLU A 1 253 ? 110.638 110.542 120.029 1.00 387.08 ? 253 GLU A CB    1 
ATOM   1411 C CG    . GLU A 1 253 ? 109.712 109.661 119.201 1.00 387.08 ? 253 GLU A CG    1 
ATOM   1412 C CD    . GLU A 1 253 ? 108.286 110.165 119.178 1.00 387.08 ? 253 GLU A CD    1 
ATOM   1413 O OE1   . GLU A 1 253 ? 107.945 111.015 120.019 1.00 387.08 ? 253 GLU A OE1   1 
ATOM   1414 O OE2   . GLU A 1 253 ? 107.507 109.716 118.312 1.00 387.08 ? 253 GLU A OE2   1 
ATOM   1415 N N     . LEU A 1 254 ? 113.344 110.983 121.807 1.00 406.96 ? 254 LEU A N     1 
ATOM   1416 C CA    . LEU A 1 254 ? 114.225 111.903 122.514 1.00 406.96 ? 254 LEU A CA    1 
ATOM   1417 C C     . LEU A 1 254 ? 115.679 111.752 122.094 1.00 406.96 ? 254 LEU A C     1 
ATOM   1418 O O     . LEU A 1 254 ? 116.415 112.744 122.073 1.00 406.96 ? 254 LEU A O     1 
ATOM   1419 C CB    . LEU A 1 254 ? 114.085 111.713 124.022 1.00 406.96 ? 254 LEU A CB    1 
ATOM   1420 C CG    . LEU A 1 254 ? 112.722 112.150 124.552 1.00 406.96 ? 254 LEU A CG    1 
ATOM   1421 C CD1   . LEU A 1 254 ? 112.593 111.883 126.044 1.00 406.96 ? 254 LEU A CD1   1 
ATOM   1422 C CD2   . LEU A 1 254 ? 112.508 113.612 124.230 1.00 406.96 ? 254 LEU A CD2   1 
ATOM   1423 N N     . ASN A 1 255 ? 116.124 110.538 121.756 1.00 375.38 ? 255 ASN A N     1 
ATOM   1424 C CA    . ASN A 1 255 ? 117.515 110.399 121.345 1.00 375.38 ? 255 ASN A CA    1 
ATOM   1425 C C     . ASN A 1 255 ? 117.725 110.977 119.950 1.00 375.38 ? 255 ASN A C     1 
ATOM   1426 O O     . ASN A 1 255 ? 118.787 111.534 119.653 1.00 375.38 ? 255 ASN A O     1 
ATOM   1427 C CB    . ASN A 1 255 ? 117.933 108.929 121.386 1.00 375.38 ? 255 ASN A CB    1 
ATOM   1428 C CG    . ASN A 1 255 ? 117.937 108.362 122.791 1.00 375.38 ? 255 ASN A CG    1 
ATOM   1429 O OD1   . ASN A 1 255 ? 118.219 109.069 123.757 1.00 375.38 ? 255 ASN A OD1   1 
ATOM   1430 N ND2   . ASN A 1 255 ? 117.623 107.076 122.912 1.00 375.38 ? 255 ASN A ND2   1 
ATOM   1431 N N     . GLY A 1 256 ? 116.718 110.866 119.087 1.00 292.11 ? 256 GLY A N     1 
ATOM   1432 C CA    . GLY A 1 256 ? 116.874 111.265 117.703 1.00 292.11 ? 256 GLY A CA    1 
ATOM   1433 C C     . GLY A 1 256 ? 117.995 110.559 116.973 1.00 292.11 ? 256 GLY A C     1 
ATOM   1434 O O     . GLY A 1 256 ? 118.565 109.584 117.474 1.00 292.11 ? 256 GLY A O     1 
ATOM   1435 N N     . ILE A 1 257 ? 118.315 111.044 115.777 1.00 332.33 ? 257 ILE A N     1 
ATOM   1436 C CA    . ILE A 1 257 ? 119.428 110.537 114.985 1.00 332.33 ? 257 ILE A CA    1 
ATOM   1437 C C     . ILE A 1 257 ? 120.139 111.732 114.366 1.00 332.33 ? 257 ILE A C     1 
ATOM   1438 O O     . ILE A 1 257 ? 119.490 112.642 113.835 1.00 332.33 ? 257 ILE A O     1 
ATOM   1439 C CB    . ILE A 1 257 ? 118.961 109.535 113.912 1.00 332.33 ? 257 ILE A CB    1 
ATOM   1440 C CG1   . ILE A 1 257 ? 120.161 108.970 113.148 1.00 332.33 ? 257 ILE A CG1   1 
ATOM   1441 C CG2   . ILE A 1 257 ? 117.935 110.161 112.971 1.00 332.33 ? 257 ILE A CG2   1 
ATOM   1442 C CD1   . ILE A 1 257 ? 119.839 107.745 112.325 1.00 332.33 ? 257 ILE A CD1   1 
ATOM   1443 N N     . LYS A 1 258 ? 121.466 111.747 114.462 1.00 347.12 ? 258 LYS A N     1 
ATOM   1444 C CA    . LYS A 1 258 ? 122.231 112.886 113.984 1.00 347.12 ? 258 LYS A CA    1 
ATOM   1445 C C     . LYS A 1 258 ? 122.338 112.847 112.463 1.00 347.12 ? 258 LYS A C     1 
ATOM   1446 O O     . LYS A 1 258 ? 122.397 111.773 111.858 1.00 347.12 ? 258 LYS A O     1 
ATOM   1447 C CB    . LYS A 1 258 ? 123.626 112.893 114.613 1.00 347.12 ? 258 LYS A CB    1 
ATOM   1448 C CG    . LYS A 1 258 ? 124.450 114.128 114.287 1.00 347.12 ? 258 LYS A CG    1 
ATOM   1449 C CD    . LYS A 1 258 ? 125.785 114.114 115.009 1.00 347.12 ? 258 LYS A CD    1 
ATOM   1450 C CE    . LYS A 1 258 ? 126.611 115.340 114.652 1.00 347.12 ? 258 LYS A CE    1 
ATOM   1451 N NZ    . LYS A 1 258 ? 127.973 115.286 115.250 1.00 347.12 ? 258 LYS A NZ    1 
ATOM   1452 N N     . VAL A 1 259 ? 122.362 114.028 111.849 1.00 373.06 ? 259 VAL A N     1 
ATOM   1453 C CA    . VAL A 1 259 ? 122.414 114.139 110.396 1.00 373.06 ? 259 VAL A CA    1 
ATOM   1454 C C     . VAL A 1 259 ? 123.720 114.813 109.998 1.00 373.06 ? 259 VAL A C     1 
ATOM   1455 O O     . VAL A 1 259 ? 124.100 115.837 110.576 1.00 373.06 ? 259 VAL A O     1 
ATOM   1456 C CB    . VAL A 1 259 ? 121.201 114.913 109.852 1.00 373.06 ? 259 VAL A CB    1 
ATOM   1457 C CG1   . VAL A 1 259 ? 121.308 115.083 108.344 1.00 373.06 ? 259 VAL A CG1   1 
ATOM   1458 C CG2   . VAL A 1 259 ? 119.915 114.197 110.222 1.00 373.06 ? 259 VAL A CG2   1 
ATOM   1459 N N     . ASP A 1 260 ? 124.414 114.249 109.014 1.00 322.79 ? 260 ASP A N     1 
ATOM   1460 C CA    . ASP A 1 260 ? 125.624 114.860 108.471 1.00 322.79 ? 260 ASP A CA    1 
ATOM   1461 C C     . ASP A 1 260 ? 125.209 115.817 107.357 1.00 322.79 ? 260 ASP A C     1 
ATOM   1462 O O     . ASP A 1 260 ? 124.896 115.387 106.243 1.00 322.79 ? 260 ASP A O     1 
ATOM   1463 C CB    . ASP A 1 260 ? 126.592 113.783 107.976 1.00 322.79 ? 260 ASP A CB    1 
ATOM   1464 C CG    . ASP A 1 260 ? 127.857 114.356 107.358 1.00 322.79 ? 260 ASP A CG    1 
ATOM   1465 O OD1   . ASP A 1 260 ? 127.768 115.088 106.351 1.00 322.79 ? 260 ASP A OD1   1 
ATOM   1466 O OD2   . ASP A 1 260 ? 128.951 114.070 107.886 1.00 322.79 ? 260 ASP A OD2   1 
ATOM   1467 N N     . LEU A 1 261 ? 125.203 117.117 107.662 1.00 332.38 ? 261 LEU A N     1 
ATOM   1468 C CA    . LEU A 1 261 ? 124.740 118.107 106.695 1.00 332.38 ? 261 LEU A CA    1 
ATOM   1469 C C     . LEU A 1 261 ? 125.711 118.233 105.528 1.00 332.38 ? 261 LEU A C     1 
ATOM   1470 O O     . LEU A 1 261 ? 125.304 118.587 104.413 1.00 332.38 ? 261 LEU A O     1 
ATOM   1471 C CB    . LEU A 1 261 ? 124.537 119.460 107.377 1.00 332.38 ? 261 LEU A CB    1 
ATOM   1472 C CG    . LEU A 1 261 ? 123.514 119.480 108.515 1.00 332.38 ? 261 LEU A CG    1 
ATOM   1473 C CD1   . LEU A 1 261 ? 123.482 120.844 109.187 1.00 332.38 ? 261 LEU A CD1   1 
ATOM   1474 C CD2   . LEU A 1 261 ? 122.131 119.094 108.008 1.00 332.38 ? 261 LEU A CD2   1 
ATOM   1475 N N     . GLU A 1 262 ? 126.996 117.971 105.782 1.00 326.05 ? 262 GLU A N     1 
ATOM   1476 C CA    . GLU A 1 262 ? 128.014 118.001 104.735 1.00 326.05 ? 262 GLU A CA    1 
ATOM   1477 C C     . GLU A 1 262 ? 127.632 117.108 103.563 1.00 326.05 ? 262 GLU A C     1 
ATOM   1478 O O     . GLU A 1 262 ? 127.491 117.587 102.432 1.00 326.05 ? 262 GLU A O     1 
ATOM   1479 C CB    . GLU A 1 262 ? 129.366 117.580 105.311 1.00 326.05 ? 262 GLU A CB    1 
ATOM   1480 C CG    . GLU A 1 262 ? 129.945 118.548 106.326 1.00 326.05 ? 262 GLU A CG    1 
ATOM   1481 C CD    . GLU A 1 262 ? 131.161 117.982 107.037 1.00 326.05 ? 262 GLU A CD    1 
ATOM   1482 O OE1   . GLU A 1 262 ? 131.715 116.970 106.558 1.00 326.05 ? 262 GLU A OE1   1 
ATOM   1483 O OE2   . GLU A 1 262 ? 131.559 118.547 108.078 1.00 326.05 ? 262 GLU A OE2   1 
ATOM   1484 N N     . ASN A 1 263 ? 127.487 115.802 103.810 1.00 318.17 ? 263 ASN A N     1 
ATOM   1485 C CA    . ASN A 1 263 ? 127.135 114.873 102.740 1.00 318.17 ? 263 ASN A CA    1 
ATOM   1486 C C     . ASN A 1 263 ? 125.791 115.231 102.120 1.00 318.17 ? 263 ASN A C     1 
ATOM   1487 O O     . ASN A 1 263 ? 125.587 115.036 100.916 1.00 318.17 ? 263 ASN A O     1 
ATOM   1488 C CB    . ASN A 1 263 ? 127.118 113.442 103.275 1.00 318.17 ? 263 ASN A CB    1 
ATOM   1489 C CG    . ASN A 1 263 ? 127.132 112.408 102.168 1.00 318.17 ? 263 ASN A CG    1 
ATOM   1490 O OD1   . ASN A 1 263 ? 127.494 112.706 101.030 1.00 318.17 ? 263 ASN A OD1   1 
ATOM   1491 N ND2   . ASN A 1 263 ? 126.738 111.184 102.498 1.00 318.17 ? 263 ASN A ND2   1 
ATOM   1492 N N     . LEU A 1 264 ? 124.888 115.811 102.910 1.00 278.13 ? 264 LEU A N     1 
ATOM   1493 C CA    . LEU A 1 264 ? 123.577 116.192 102.394 1.00 278.13 ? 264 LEU A CA    1 
ATOM   1494 C C     . LEU A 1 264 ? 123.718 117.258 101.318 1.00 278.13 ? 264 LEU A C     1 
ATOM   1495 O O     . LEU A 1 264 ? 123.352 117.039 100.158 1.00 278.13 ? 264 LEU A O     1 
ATOM   1496 C CB    . LEU A 1 264 ? 122.679 116.685 103.529 1.00 278.13 ? 264 LEU A CB    1 
ATOM   1497 C CG    . LEU A 1 264 ? 121.281 117.133 103.097 1.00 278.13 ? 264 LEU A CG    1 
ATOM   1498 C CD1   . LEU A 1 264 ? 120.544 116.001 102.398 1.00 278.13 ? 264 LEU A CD1   1 
ATOM   1499 C CD2   . LEU A 1 264 ? 120.482 117.646 104.285 1.00 278.13 ? 264 LEU A CD2   1 
ATOM   1500 N N     . GLN A 1 265 ? 124.205 118.439 101.705 1.00 305.24 ? 265 GLN A N     1 
ATOM   1501 C CA    . GLN A 1 265 ? 124.388 119.532 100.752 1.00 305.24 ? 265 GLN A CA    1 
ATOM   1502 C C     . GLN A 1 265 ? 125.292 119.112 99.597  1.00 305.24 ? 265 GLN A C     1 
ATOM   1503 O O     . GLN A 1 265 ? 125.078 119.522 98.449  1.00 305.24 ? 265 GLN A O     1 
ATOM   1504 C CB    . GLN A 1 265 ? 124.957 120.756 101.468 1.00 305.24 ? 265 GLN A CB    1 
ATOM   1505 C CG    . GLN A 1 265 ? 124.881 122.037 100.659 1.00 305.24 ? 265 GLN A CG    1 
ATOM   1506 C CD    . GLN A 1 265 ? 125.224 123.262 101.481 1.00 305.24 ? 265 GLN A CD    1 
ATOM   1507 O OE1   . GLN A 1 265 ? 125.771 123.153 102.578 1.00 305.24 ? 265 GLN A OE1   1 
ATOM   1508 N NE2   . GLN A 1 265 ? 124.905 124.438 100.954 1.00 305.24 ? 265 GLN A NE2   1 
ATOM   1509 N N     . LYS A 1 266 ? 126.338 118.332 99.886  1.00 316.20 ? 266 LYS A N     1 
ATOM   1510 C CA    . LYS A 1 266 ? 127.201 117.808 98.831  1.00 316.20 ? 266 LYS A CA    1 
ATOM   1511 C C     . LYS A 1 266 ? 126.389 117.063 97.777  1.00 316.20 ? 266 LYS A C     1 
ATOM   1512 O O     . LYS A 1 266 ? 126.391 117.439 96.598  1.00 316.20 ? 266 LYS A O     1 
ATOM   1513 C CB    . LYS A 1 266 ? 128.270 116.905 99.449  1.00 316.20 ? 266 LYS A CB    1 
ATOM   1514 C CG    . LYS A 1 266 ? 129.075 116.083 98.463  1.00 316.20 ? 266 LYS A CG    1 
ATOM   1515 C CD    . LYS A 1 266 ? 130.024 115.155 99.203  1.00 316.20 ? 266 LYS A CD    1 
ATOM   1516 C CE    . LYS A 1 266 ? 130.563 114.060 98.301  1.00 316.20 ? 266 LYS A CE    1 
ATOM   1517 N NZ    . LYS A 1 266 ? 131.387 113.079 99.058  1.00 316.20 ? 266 LYS A NZ    1 
ATOM   1518 N N     . SER A 1 267 ? 125.739 115.964 98.173  1.00 299.20 ? 267 SER A N     1 
ATOM   1519 C CA    . SER A 1 267 ? 124.943 115.183 97.232  1.00 299.20 ? 267 SER A CA    1 
ATOM   1520 C C     . SER A 1 267 ? 123.877 116.041 96.557  1.00 299.20 ? 267 SER A C     1 
ATOM   1521 O O     . SER A 1 267 ? 123.503 115.784 95.408  1.00 299.20 ? 267 SER A O     1 
ATOM   1522 C CB    . SER A 1 267 ? 124.312 113.991 97.949  1.00 299.20 ? 267 SER A CB    1 
ATOM   1523 O OG    . SER A 1 267 ? 125.306 113.113 98.448  1.00 299.20 ? 267 SER A OG    1 
ATOM   1524 N N     . THR A 1 268 ? 123.365 117.056 97.262  1.00 303.83 ? 268 THR A N     1 
ATOM   1525 C CA    . THR A 1 268 ? 122.422 117.989 96.651  1.00 303.83 ? 268 THR A CA    1 
ATOM   1526 C C     . THR A 1 268 ? 123.057 118.723 95.476  1.00 303.83 ? 268 THR A C     1 
ATOM   1527 O O     . THR A 1 268 ? 122.480 118.785 94.384  1.00 303.83 ? 268 THR A O     1 
ATOM   1528 C CB    . THR A 1 268 ? 121.922 118.988 97.697  1.00 303.83 ? 268 THR A CB    1 
ATOM   1529 O OG1   . THR A 1 268 ? 121.366 118.281 98.812  1.00 303.83 ? 268 THR A OG1   1 
ATOM   1530 C CG2   . THR A 1 268 ? 120.858 119.893 97.105  1.00 303.83 ? 268 THR A CG2   1 
ATOM   1531 N N     . ASN A 1 269 ? 124.272 119.243 95.674  1.00 348.89 ? 269 ASN A N     1 
ATOM   1532 C CA    . ASN A 1 269 ? 124.988 119.931 94.600  1.00 348.89 ? 269 ASN A CA    1 
ATOM   1533 C C     . ASN A 1 269 ? 125.304 118.966 93.467  1.00 348.89 ? 269 ASN A C     1 
ATOM   1534 O O     . ASN A 1 269 ? 125.259 119.337 92.287  1.00 348.89 ? 269 ASN A O     1 
ATOM   1535 C CB    . ASN A 1 269 ? 126.269 120.563 95.143  1.00 348.89 ? 269 ASN A CB    1 
ATOM   1536 C CG    . ASN A 1 269 ? 125.998 121.605 96.209  1.00 348.89 ? 269 ASN A CG    1 
ATOM   1537 O OD1   . ASN A 1 269 ? 124.963 122.271 96.193  1.00 348.89 ? 269 ASN A OD1   1 
ATOM   1538 N ND2   . ASN A 1 269 ? 126.929 121.749 97.144  1.00 348.89 ? 269 ASN A ND2   1 
ATOM   1539 N N     . GLU A 1 270 ? 125.585 117.713 93.813  1.00 334.30 ? 270 GLU A N     1 
ATOM   1540 C CA    . GLU A 1 270 ? 125.918 116.705 92.813  1.00 334.30 ? 270 GLU A CA    1 
ATOM   1541 C C     . GLU A 1 270 ? 124.712 116.430 91.924  1.00 334.30 ? 270 GLU A C     1 
ATOM   1542 O O     . GLU A 1 270 ? 124.798 116.536 90.694  1.00 334.30 ? 270 GLU A O     1 
ATOM   1543 C CB    . GLU A 1 270 ? 126.398 115.426 93.494  1.00 334.30 ? 270 GLU A CB    1 
ATOM   1544 C CG    . GLU A 1 270 ? 127.702 115.583 94.256  1.00 334.30 ? 270 GLU A CG    1 
ATOM   1545 C CD    . GLU A 1 270 ? 128.167 114.285 94.883  1.00 334.30 ? 270 GLU A CD    1 
ATOM   1546 O OE1   . GLU A 1 270 ? 127.398 113.302 94.862  1.00 334.30 ? 270 GLU A OE1   1 
ATOM   1547 O OE2   . GLU A 1 270 ? 129.307 114.246 95.389  1.00 334.30 ? 270 GLU A OE2   1 
ATOM   1548 N N     . ILE A 1 271 ? 123.601 116.016 92.531  1.00 334.47 ? 271 ILE A N     1 
ATOM   1549 C CA    . ILE A 1 271 ? 122.384 115.744 91.774  1.00 334.47 ? 271 ILE A CA    1 
ATOM   1550 C C     . ILE A 1 271 ? 121.940 116.986 91.008  1.00 334.47 ? 271 ILE A C     1 
ATOM   1551 O O     . ILE A 1 271 ? 121.378 116.881 89.914  1.00 334.47 ? 271 ILE A O     1 
ATOM   1552 C CB    . ILE A 1 271 ? 121.280 115.229 92.716  1.00 334.47 ? 271 ILE A CB    1 
ATOM   1553 C CG1   . ILE A 1 271 ? 121.743 113.957 93.426  1.00 334.47 ? 271 ILE A CG1   1 
ATOM   1554 C CG2   . ILE A 1 271 ? 119.990 114.970 91.953  1.00 334.47 ? 271 ILE A CG2   1 
ATOM   1555 C CD1   . ILE A 1 271 ? 122.039 112.809 92.488  1.00 334.47 ? 271 ILE A CD1   1 
ATOM   1556 N N     . LEU A 1 272 ? 122.197 118.184 91.547  1.00 341.96 ? 272 LEU A N     1 
ATOM   1557 C CA    . LEU A 1 272 ? 121.861 119.400 90.810  1.00 341.96 ? 272 LEU A CA    1 
ATOM   1558 C C     . LEU A 1 272 ? 122.703 119.542 89.546  1.00 341.96 ? 272 LEU A C     1 
ATOM   1559 O O     . LEU A 1 272 ? 122.186 119.919 88.486  1.00 341.96 ? 272 LEU A O     1 
ATOM   1560 C CB    . LEU A 1 272 ? 122.042 120.623 91.708  1.00 341.96 ? 272 LEU A CB    1 
ATOM   1561 C CG    . LEU A 1 272 ? 121.710 121.969 91.068  1.00 341.96 ? 272 LEU A CG    1 
ATOM   1562 C CD1   . LEU A 1 272 ? 120.264 121.990 90.598  1.00 341.96 ? 272 LEU A CD1   1 
ATOM   1563 C CD2   . LEU A 1 272 ? 121.978 123.107 92.039  1.00 341.96 ? 272 LEU A CD2   1 
ATOM   1564 N N     . ASN A 1 273 ? 124.011 119.295 89.648  1.00 355.73 ? 273 ASN A N     1 
ATOM   1565 C CA    . ASN A 1 273 ? 124.868 119.353 88.466  1.00 355.73 ? 273 ASN A CA    1 
ATOM   1566 C C     . ASN A 1 273 ? 124.471 118.289 87.448  1.00 355.73 ? 273 ASN A C     1 
ATOM   1567 O O     . ASN A 1 273 ? 124.496 118.526 86.236  1.00 355.73 ? 273 ASN A O     1 
ATOM   1568 C CB    . ASN A 1 273 ? 126.332 119.191 88.874  1.00 355.73 ? 273 ASN A CB    1 
ATOM   1569 C CG    . ASN A 1 273 ? 126.884 120.428 89.557  1.00 355.73 ? 273 ASN A CG    1 
ATOM   1570 O OD1   . ASN A 1 273 ? 126.344 121.523 89.412  1.00 355.73 ? 273 ASN A OD1   1 
ATOM   1571 N ND2   . ASN A 1 273 ? 127.967 120.256 90.306  1.00 355.73 ? 273 ASN A ND2   1 
ATOM   1572 N N     . GLU A 1 274 ? 124.037 117.124 87.935  1.00 373.58 ? 274 GLU A N     1 
ATOM   1573 C CA    . GLU A 1 274 ? 123.551 116.076 87.041  1.00 373.58 ? 274 GLU A CA    1 
ATOM   1574 C C     . GLU A 1 274 ? 122.249 116.500 86.374  1.00 373.58 ? 274 GLU A C     1 
ATOM   1575 O O     . GLU A 1 274 ? 122.005 116.196 85.202  1.00 373.58 ? 274 GLU A O     1 
ATOM   1576 C CB    . GLU A 1 274 ? 123.362 114.772 87.816  1.00 373.58 ? 274 GLU A CB    1 
ATOM   1577 C CG    . GLU A 1 274 ? 124.640 114.223 88.427  1.00 373.58 ? 274 GLU A CG    1 
ATOM   1578 C CD    . GLU A 1 274 ? 124.409 112.938 89.195  1.00 373.58 ? 274 GLU A CD    1 
ATOM   1579 O OE1   . GLU A 1 274 ? 123.250 112.478 89.252  1.00 373.58 ? 274 GLU A OE1   1 
ATOM   1580 O OE2   . GLU A 1 274 ? 125.387 112.389 89.745  1.00 373.58 ? 274 GLU A OE2   1 
ATOM   1581 N N     . LEU A 1 275 ? 121.426 117.250 87.102  1.00 338.29 ? 275 LEU A N     1 
ATOM   1582 C CA    . LEU A 1 275 ? 120.178 117.748 86.545  1.00 338.29 ? 275 LEU A CA    1 
ATOM   1583 C C     . LEU A 1 275 ? 120.434 118.768 85.452  1.00 338.29 ? 275 LEU A C     1 
ATOM   1584 O O     . LEU A 1 275 ? 119.780 118.739 84.407  1.00 338.29 ? 275 LEU A O     1 
ATOM   1585 C CB    . LEU A 1 275 ? 119.309 118.354 87.645  1.00 338.29 ? 275 LEU A CB    1 
ATOM   1586 C CG    . LEU A 1 275 ? 117.820 118.379 87.303  1.00 338.29 ? 275 LEU A CG    1 
ATOM   1587 C CD1   . LEU A 1 275 ? 117.265 116.977 87.266  1.00 338.29 ? 275 LEU A CD1   1 
ATOM   1588 C CD2   . LEU A 1 275 ? 117.058 119.233 88.303  1.00 338.29 ? 275 LEU A CD2   1 
ATOM   1589 N N     . ASN A 1 276 ? 121.318 119.731 85.707  1.00 302.64 ? 276 ASN A N     1 
ATOM   1590 C CA    . ASN A 1 276 ? 121.668 120.676 84.653  1.00 302.64 ? 276 ASN A CA    1 
ATOM   1591 C C     . ASN A 1 276 ? 122.309 119.983 83.450  1.00 302.64 ? 276 ASN A C     1 
ATOM   1592 O O     . ASN A 1 276 ? 122.052 120.374 82.303  1.00 302.64 ? 276 ASN A O     1 
ATOM   1593 C CB    . ASN A 1 276 ? 122.599 121.753 85.211  1.00 302.64 ? 276 ASN A CB    1 
ATOM   1594 C CG    . ASN A 1 276 ? 121.926 122.616 86.259  1.00 302.64 ? 276 ASN A CG    1 
ATOM   1595 O OD1   . ASN A 1 276 ? 120.716 122.834 86.217  1.00 302.64 ? 276 ASN A OD1   1 
ATOM   1596 N ND2   . ASN A 1 276 ? 122.711 123.112 87.209  1.00 302.64 ? 276 ASN A ND2   1 
ATOM   1597 N N     . ILE A 1 277 ? 123.139 118.954 83.679  1.00 334.89 ? 277 ILE A N     1 
ATOM   1598 C CA    . ILE A 1 277 ? 123.678 118.178 82.558  1.00 334.89 ? 277 ILE A CA    1 
ATOM   1599 C C     . ILE A 1 277 ? 122.543 117.550 81.752  1.00 334.89 ? 277 ILE A C     1 
ATOM   1600 O O     . ILE A 1 277 ? 122.525 117.606 80.515  1.00 334.89 ? 277 ILE A O     1 
ATOM   1601 C CB    . ILE A 1 277 ? 124.671 117.121 83.068  1.00 334.89 ? 277 ILE A CB    1 
ATOM   1602 C CG1   . ILE A 1 277 ? 126.031 117.766 83.346  1.00 334.89 ? 277 ILE A CG1   1 
ATOM   1603 C CG2   . ILE A 1 277 ? 124.814 115.992 82.063  1.00 334.89 ? 277 ILE A CG2   1 
ATOM   1604 C CD1   . ILE A 1 277 ? 126.964 116.895 84.153  1.00 334.89 ? 277 ILE A CD1   1 
ATOM   1605 N N     . GLU A 1 278 ? 121.547 117.000 82.458  1.00 362.90 ? 278 GLU A N     1 
ATOM   1606 C CA    . GLU A 1 278 ? 120.354 116.452 81.814  1.00 362.90 ? 278 GLU A CA    1 
ATOM   1607 C C     . GLU A 1 278 ? 119.626 117.499 80.999  1.00 362.90 ? 278 GLU A C     1 
ATOM   1608 O O     . GLU A 1 278 ? 119.308 117.268 79.829  1.00 362.90 ? 278 GLU A O     1 
ATOM   1609 C CB    . GLU A 1 278 ? 119.407 115.779 82.810  1.00 362.90 ? 278 GLU A CB    1 
ATOM   1610 C CG    . GLU A 1 278 ? 119.613 114.268 82.978  1.00 362.90 ? 278 GLU A CG    1 
ATOM   1611 C CD    . GLU A 1 278 ? 120.979 113.746 82.609  1.00 362.90 ? 278 GLU A CD    1 
ATOM   1612 O OE1   . GLU A 1 278 ? 121.954 114.103 83.300  1.00 362.90 ? 278 GLU A OE1   1 
ATOM   1613 O OE2   . GLU A 1 278 ? 121.086 113.040 81.577  1.00 362.90 ? 278 GLU A OE2   1 
ATOM   1614 N N     . LYS A 1 279 ? 119.321 118.629 81.622  1.00 364.51 ? 279 LYS A N     1 
ATOM   1615 C CA    . LYS A 1 279 ? 118.575 119.696 80.972  1.00 364.51 ? 279 LYS A CA    1 
ATOM   1616 C C     . LYS A 1 279 ? 119.276 120.114 79.686  1.00 364.51 ? 279 LYS A C     1 
ATOM   1617 O O     . LYS A 1 279 ? 118.653 120.175 78.620  1.00 364.51 ? 279 LYS A O     1 
ATOM   1618 C CB    . LYS A 1 279 ? 118.437 120.860 81.950  1.00 364.51 ? 279 LYS A CB    1 
ATOM   1619 C CG    . LYS A 1 279 ? 117.702 122.083 81.457  1.00 364.51 ? 279 LYS A CG    1 
ATOM   1620 C CD    . LYS A 1 279 ? 117.591 123.075 82.608  1.00 364.51 ? 279 LYS A CD    1 
ATOM   1621 C CE    . LYS A 1 279 ? 116.878 124.349 82.207  1.00 364.51 ? 279 LYS A CE    1 
ATOM   1622 N NZ    . LYS A 1 279 ? 116.774 125.300 83.347  1.00 364.51 ? 279 LYS A NZ    1 
ATOM   1623 N N     . ASP A 1 280 ? 120.573 120.419 79.770  1.00 407.20 ? 280 ASP A N     1 
ATOM   1624 C CA    . ASP A 1 280 ? 121.303 120.910 78.605  1.00 407.20 ? 280 ASP A CA    1 
ATOM   1625 C C     . ASP A 1 280 ? 121.343 119.846 77.510  1.00 407.20 ? 280 ASP A C     1 
ATOM   1626 O O     . ASP A 1 280 ? 121.004 120.119 76.349  1.00 407.20 ? 280 ASP A O     1 
ATOM   1627 C CB    . ASP A 1 280 ? 122.718 121.326 79.005  1.00 407.20 ? 280 ASP A CB    1 
ATOM   1628 C CG    . ASP A 1 280 ? 122.727 122.395 80.081  1.00 407.20 ? 280 ASP A CG    1 
ATOM   1629 O OD1   . ASP A 1 280 ? 121.779 123.208 80.121  1.00 407.20 ? 280 ASP A OD1   1 
ATOM   1630 O OD2   . ASP A 1 280 ? 123.680 122.419 80.886  1.00 407.20 ? 280 ASP A OD2   1 
ATOM   1631 N N     . ASN A 1 281 ? 121.710 118.612 77.875  1.00 486.57 ? 281 ASN A N     1 
ATOM   1632 C CA    . ASN A 1 281 ? 121.917 117.547 76.898  1.00 486.57 ? 281 ASN A CA    1 
ATOM   1633 C C     . ASN A 1 281 ? 120.588 117.075 76.320  1.00 486.57 ? 281 ASN A C     1 
ATOM   1634 O O     . ASN A 1 281 ? 120.541 116.534 75.208  1.00 486.57 ? 281 ASN A O     1 
ATOM   1635 C CB    . ASN A 1 281 ? 122.671 116.384 77.545  1.00 486.57 ? 281 ASN A CB    1 
ATOM   1636 C CG    . ASN A 1 281 ? 122.887 115.227 76.591  1.00 486.57 ? 281 ASN A CG    1 
ATOM   1637 O OD1   . ASN A 1 281 ? 122.212 114.202 76.679  1.00 486.57 ? 281 ASN A OD1   1 
ATOM   1638 N ND2   . ASN A 1 281 ? 123.832 115.385 75.669  1.00 486.57 ? 281 ASN A ND2   1 
ATOM   1639 N N     . LEU A 1 282 ? 119.482 117.404 76.987  1.00 505.64 ? 282 LEU A N     1 
ATOM   1640 C CA    . LEU A 1 282 ? 118.182 116.969 76.504  1.00 505.64 ? 282 LEU A CA    1 
ATOM   1641 C C     . LEU A 1 282 ? 117.568 118.061 75.650  1.00 505.64 ? 282 LEU A C     1 
ATOM   1642 O O     . LEU A 1 282 ? 116.870 117.771 74.672  1.00 505.64 ? 282 LEU A O     1 
ATOM   1643 C CB    . LEU A 1 282 ? 117.271 116.622 77.683  1.00 505.64 ? 282 LEU A CB    1 
ATOM   1644 C CG    . LEU A 1 282 ? 115.794 116.363 77.383  1.00 505.64 ? 282 LEU A CG    1 
ATOM   1645 C CD1   . LEU A 1 282 ? 115.634 115.190 76.429  1.00 505.64 ? 282 LEU A CD1   1 
ATOM   1646 C CD2   . LEU A 1 282 ? 115.020 116.122 78.669  1.00 505.64 ? 282 LEU A CD2   1 
ATOM   1647 N N     . LYS A 1 283 ? 117.815 119.324 75.991  1.00 534.23 ? 283 LYS A N     1 
ATOM   1648 C CA    . LYS A 1 283 ? 117.255 120.387 75.174  1.00 534.23 ? 283 LYS A CA    1 
ATOM   1649 C C     . LYS A 1 283 ? 118.028 120.456 73.867  1.00 534.23 ? 283 LYS A C     1 
ATOM   1650 O O     . LYS A 1 283 ? 117.490 120.863 72.831  1.00 534.23 ? 283 LYS A O     1 
ATOM   1651 C CB    . LYS A 1 283 ? 117.319 121.733 75.894  1.00 534.23 ? 283 LYS A CB    1 
ATOM   1652 C CG    . LYS A 1 283 ? 116.214 121.985 76.896  1.00 534.23 ? 283 LYS A CG    1 
ATOM   1653 C CD    . LYS A 1 283 ? 116.441 123.314 77.592  1.00 534.23 ? 283 LYS A CD    1 
ATOM   1654 C CE    . LYS A 1 283 ? 115.403 123.567 78.664  1.00 534.23 ? 283 LYS A CE    1 
ATOM   1655 N NZ    . LYS A 1 283 ? 115.633 124.866 79.345  1.00 534.23 ? 283 LYS A NZ    1 
ATOM   1656 N N     . LYS A 1 284 ? 119.301 120.042 73.901  1.00 543.32 ? 284 LYS A N     1 
ATOM   1657 C CA    . LYS A 1 284 ? 119.996 119.694 72.666  1.00 543.32 ? 284 LYS A CA    1 
ATOM   1658 C C     . LYS A 1 284 ? 119.372 118.466 72.013  1.00 543.32 ? 284 LYS A C     1 
ATOM   1659 O O     . LYS A 1 284 ? 119.171 118.438 70.794  1.00 543.32 ? 284 LYS A O     1 
ATOM   1660 C CB    . LYS A 1 284 ? 121.481 119.454 72.944  1.00 543.32 ? 284 LYS A CB    1 
ATOM   1661 C CG    . LYS A 1 284 ? 122.238 120.680 73.416  1.00 543.32 ? 284 LYS A CG    1 
ATOM   1662 C CD    . LYS A 1 284 ? 123.689 120.338 73.715  1.00 543.32 ? 284 LYS A CD    1 
ATOM   1663 C CE    . LYS A 1 284 ? 124.458 121.554 74.200  1.00 543.32 ? 284 LYS A CE    1 
ATOM   1664 N NZ    . LYS A 1 284 ? 125.875 121.216 74.507  1.00 543.32 ? 284 LYS A NZ    1 
ATOM   1665 N N     . LYS A 1 285 ? 119.060 117.433 72.808  1.00 543.76 ? 285 LYS A N     1 
ATOM   1666 C CA    . LYS A 1 285 ? 118.431 116.242 72.243  1.00 543.76 ? 285 LYS A CA    1 
ATOM   1667 C C     . LYS A 1 285 ? 116.997 116.504 71.795  1.00 543.76 ? 285 LYS A C     1 
ATOM   1668 O O     . LYS A 1 285 ? 116.498 115.814 70.899  1.00 543.76 ? 285 LYS A O     1 
ATOM   1669 C CB    . LYS A 1 285 ? 118.469 115.094 73.251  1.00 543.76 ? 285 LYS A CB    1 
ATOM   1670 C CG    . LYS A 1 285 ? 119.750 114.275 73.209  1.00 543.76 ? 285 LYS A CG    1 
ATOM   1671 C CD    . LYS A 1 285 ? 119.746 113.189 74.271  1.00 543.76 ? 285 LYS A CD    1 
ATOM   1672 C CE    . LYS A 1 285 ? 121.038 112.390 74.249  1.00 543.76 ? 285 LYS A CE    1 
ATOM   1673 N NZ    . LYS A 1 285 ? 121.058 111.336 75.301  1.00 543.76 ? 285 LYS A NZ    1 
ATOM   1674 N N     . LEU A 1 286 ? 116.321 117.485 72.393  1.00 438.33 ? 286 LEU A N     1 
ATOM   1675 C CA    . LEU A 1 286 ? 114.949 117.804 72.012  1.00 438.33 ? 286 LEU A CA    1 
ATOM   1676 C C     . LEU A 1 286 ? 114.865 118.755 70.826  1.00 438.33 ? 286 LEU A C     1 
ATOM   1677 O O     . LEU A 1 286 ? 113.753 119.071 70.390  1.00 438.33 ? 286 LEU A O     1 
ATOM   1678 C CB    . LEU A 1 286 ? 114.190 118.409 73.196  1.00 438.33 ? 286 LEU A CB    1 
ATOM   1679 C CG    . LEU A 1 286 ? 113.547 117.429 74.178  1.00 438.33 ? 286 LEU A CG    1 
ATOM   1680 C CD1   . LEU A 1 286 ? 112.891 118.176 75.328  1.00 438.33 ? 286 LEU A CD1   1 
ATOM   1681 C CD2   . LEU A 1 286 ? 112.533 116.558 73.458  1.00 438.33 ? 286 LEU A CD2   1 
ATOM   1682 N N     . LYS A 1 287 ? 116.005 119.216 70.304  1.00 479.76 ? 287 LYS A N     1 
ATOM   1683 C CA    . LYS A 1 287 ? 116.047 120.152 69.180  1.00 479.76 ? 287 LYS A CA    1 
ATOM   1684 C C     . LYS A 1 287 ? 115.303 121.446 69.496  1.00 479.76 ? 287 LYS A C     1 
ATOM   1685 O O     . LYS A 1 287 ? 114.732 122.081 68.606  1.00 479.76 ? 287 LYS A O     1 
ATOM   1686 C CB    . LYS A 1 287 ? 115.491 119.515 67.902  1.00 479.76 ? 287 LYS A CB    1 
ATOM   1687 C CG    . LYS A 1 287 ? 116.152 118.203 67.525  1.00 479.76 ? 287 LYS A CG    1 
ATOM   1688 C CD    . LYS A 1 287 ? 115.511 117.605 66.284  1.00 479.76 ? 287 LYS A CD    1 
ATOM   1689 C CE    . LYS A 1 287 ? 116.173 116.294 65.898  1.00 479.76 ? 287 LYS A CE    1 
ATOM   1690 N NZ    . LYS A 1 287 ? 115.562 115.703 64.676  1.00 479.76 ? 287 LYS A NZ    1 
ATOM   1691 N N     . ASP A 1 288 ? 115.305 121.844 70.768  1.00 530.38 ? 288 ASP A N     1 
ATOM   1692 C CA    . ASP A 1 288 ? 114.642 123.068 71.215  1.00 530.38 ? 288 ASP A CA    1 
ATOM   1693 C C     . ASP A 1 288 ? 115.332 123.508 72.501  1.00 530.38 ? 288 ASP A C     1 
ATOM   1694 O O     . ASP A 1 288 ? 115.244 122.822 73.525  1.00 530.38 ? 288 ASP A O     1 
ATOM   1695 C CB    . ASP A 1 288 ? 113.148 122.846 71.425  1.00 530.38 ? 288 ASP A CB    1 
ATOM   1696 C CG    . ASP A 1 288 ? 112.386 124.142 71.629  1.00 530.38 ? 288 ASP A CG    1 
ATOM   1697 O OD1   . ASP A 1 288 ? 113.017 125.220 71.619  1.00 530.38 ? 288 ASP A OD1   1 
ATOM   1698 O OD2   . ASP A 1 288 ? 111.150 124.085 71.797  1.00 530.38 ? 288 ASP A OD2   1 
ATOM   1699 N N     . GLU A 1 289 ? 116.036 124.640 72.441  1.00 620.19 ? 289 GLU A N     1 
ATOM   1700 C CA    . GLU A 1 289 ? 116.724 125.151 73.619  1.00 620.19 ? 289 GLU A CA    1 
ATOM   1701 C C     . GLU A 1 289 ? 115.818 125.972 74.525  1.00 620.19 ? 289 GLU A C     1 
ATOM   1702 O O     . GLU A 1 289 ? 116.199 126.250 75.668  1.00 620.19 ? 289 GLU A O     1 
ATOM   1703 C CB    . GLU A 1 289 ? 117.925 126.003 73.193  1.00 620.19 ? 289 GLU A CB    1 
ATOM   1704 C CG    . GLU A 1 289 ? 118.970 125.241 72.397  1.00 620.19 ? 289 GLU A CG    1 
ATOM   1705 C CD    . GLU A 1 289 ? 120.128 126.121 71.969  1.00 620.19 ? 289 GLU A CD    1 
ATOM   1706 O OE1   . GLU A 1 289 ? 120.092 127.336 72.259  1.00 620.19 ? 289 GLU A OE1   1 
ATOM   1707 O OE2   . GLU A 1 289 ? 121.074 125.600 71.341  1.00 620.19 ? 289 GLU A OE2   1 
ATOM   1708 N N     . ASN A 1 290 ? 114.638 126.363 74.050  1.00 543.75 ? 290 ASN A N     1 
ATOM   1709 C CA    . ASN A 1 290 ? 113.729 127.205 74.814  1.00 543.75 ? 290 ASN A CA    1 
ATOM   1710 C C     . ASN A 1 290 ? 112.506 126.454 75.326  1.00 543.75 ? 290 ASN A C     1 
ATOM   1711 O O     . ASN A 1 290 ? 111.595 127.077 75.878  1.00 543.75 ? 290 ASN A O     1 
ATOM   1712 C CB    . ASN A 1 290 ? 113.287 128.403 73.969  1.00 543.75 ? 290 ASN A CB    1 
ATOM   1713 C CG    . ASN A 1 290 ? 114.452 129.266 73.528  1.00 543.75 ? 290 ASN A CG    1 
ATOM   1714 O OD1   . ASN A 1 290 ? 115.479 129.334 74.205  1.00 543.75 ? 290 ASN A OD1   1 
ATOM   1715 N ND2   . ASN A 1 290 ? 114.298 129.931 72.390  1.00 543.75 ? 290 ASN A ND2   1 
ATOM   1716 N N     . ILE A 1 291 ? 112.466 125.132 75.159  1.00 490.95 ? 291 ILE A N     1 
ATOM   1717 C CA    . ILE A 1 291 ? 111.326 124.354 75.623  1.00 490.95 ? 291 ILE A CA    1 
ATOM   1718 C C     . ILE A 1 291 ? 111.425 124.163 77.130  1.00 490.95 ? 291 ILE A C     1 
ATOM   1719 O O     . ILE A 1 291 ? 112.516 123.955 77.677  1.00 490.95 ? 291 ILE A O     1 
ATOM   1720 C CB    . ILE A 1 291 ? 111.260 123.003 74.892  1.00 490.95 ? 291 ILE A CB    1 
ATOM   1721 C CG1   . ILE A 1 291 ? 110.084 122.172 75.403  1.00 490.95 ? 291 ILE A CG1   1 
ATOM   1722 C CG2   . ILE A 1 291 ? 112.562 122.236 75.057  1.00 490.95 ? 291 ILE A CG2   1 
ATOM   1723 C CD1   . ILE A 1 291 ? 110.130 120.727 74.979  1.00 490.95 ? 291 ILE A CD1   1 
ATOM   1724 N N     . ASN A 1 292 ? 110.288 124.249 77.815  1.00 481.31 ? 292 ASN A N     1 
ATOM   1725 C CA    . ASN A 1 292 ? 110.242 123.975 79.248  1.00 481.31 ? 292 ASN A CA    1 
ATOM   1726 C C     . ASN A 1 292 ? 110.240 122.465 79.451  1.00 481.31 ? 292 ASN A C     1 
ATOM   1727 O O     . ASN A 1 292 ? 109.245 121.791 79.177  1.00 481.31 ? 292 ASN A O     1 
ATOM   1728 C CB    . ASN A 1 292 ? 109.016 124.622 79.883  1.00 481.31 ? 292 ASN A CB    1 
ATOM   1729 C CG    . ASN A 1 292 ? 108.932 124.371 81.379  1.00 481.31 ? 292 ASN A CG    1 
ATOM   1730 O OD1   . ASN A 1 292 ? 109.933 124.053 82.023  1.00 481.31 ? 292 ASN A OD1   1 
ATOM   1731 N ND2   . ASN A 1 292 ? 107.737 124.516 81.937  1.00 481.31 ? 292 ASN A ND2   1 
ATOM   1732 N N     . VAL A 1 293 ? 111.363 121.928 79.935  1.00 444.21 ? 293 VAL A N     1 
ATOM   1733 C CA    . VAL A 1 293 ? 111.476 120.492 80.169  1.00 444.21 ? 293 VAL A CA    1 
ATOM   1734 C C     . VAL A 1 293 ? 110.559 120.005 81.278  1.00 444.21 ? 293 VAL A C     1 
ATOM   1735 O O     . VAL A 1 293 ? 110.300 118.800 81.369  1.00 444.21 ? 293 VAL A O     1 
ATOM   1736 C CB    . VAL A 1 293 ? 112.932 120.109 80.503  1.00 444.21 ? 293 VAL A CB    1 
ATOM   1737 C CG1   . VAL A 1 293 ? 113.832 120.365 79.306  1.00 444.21 ? 293 VAL A CG1   1 
ATOM   1738 C CG2   . VAL A 1 293 ? 113.419 120.881 81.717  1.00 444.21 ? 293 VAL A CG2   1 
ATOM   1739 N N     . ASN A 1 294 ? 110.059 120.908 82.121  1.00 474.62 ? 294 ASN A N     1 
ATOM   1740 C CA    . ASN A 1 294 ? 109.130 120.547 83.180  1.00 474.62 ? 294 ASN A CA    1 
ATOM   1741 C C     . ASN A 1 294 ? 107.673 120.620 82.741  1.00 474.62 ? 294 ASN A C     1 
ATOM   1742 O O     . ASN A 1 294 ? 106.792 120.201 83.498  1.00 474.62 ? 294 ASN A O     1 
ATOM   1743 C CB    . ASN A 1 294 ? 109.344 121.451 84.399  1.00 474.62 ? 294 ASN A CB    1 
ATOM   1744 C CG    . ASN A 1 294 ? 110.797 121.513 84.827  1.00 474.62 ? 294 ASN A CG    1 
ATOM   1745 O OD1   . ASN A 1 294 ? 111.559 120.569 84.619  1.00 474.62 ? 294 ASN A OD1   1 
ATOM   1746 N ND2   . ASN A 1 294 ? 111.188 122.631 85.426  1.00 474.62 ? 294 ASN A ND2   1 
ATOM   1747 N N     . SER A 1 295 ? 107.402 121.136 81.545  1.00 437.14 ? 295 SER A N     1 
ATOM   1748 C CA    . SER A 1 295 ? 106.045 121.201 81.012  1.00 437.14 ? 295 SER A CA    1 
ATOM   1749 C C     . SER A 1 295 ? 105.791 119.941 80.193  1.00 437.14 ? 295 SER A C     1 
ATOM   1750 O O     . SER A 1 295 ? 106.474 119.696 79.194  1.00 437.14 ? 295 SER A O     1 
ATOM   1751 C CB    . SER A 1 295 ? 105.854 122.456 80.166  1.00 437.14 ? 295 SER A CB    1 
ATOM   1752 O OG    . SER A 1 295 ? 104.548 122.509 79.621  1.00 437.14 ? 295 SER A OG    1 
ATOM   1753 N N     . GLN A 1 296 ? 104.809 119.143 80.619  1.00 379.47 ? 296 GLN A N     1 
ATOM   1754 C CA    . GLN A 1 296 ? 104.511 117.896 79.920  1.00 379.47 ? 296 GLN A CA    1 
ATOM   1755 C C     . GLN A 1 296 ? 104.056 118.159 78.490  1.00 379.47 ? 296 GLN A C     1 
ATOM   1756 O O     . GLN A 1 296 ? 104.462 117.452 77.560  1.00 379.47 ? 296 GLN A O     1 
ATOM   1757 C CB    . GLN A 1 296 ? 103.445 117.109 80.682  1.00 379.47 ? 296 GLN A CB    1 
ATOM   1758 C CG    . GLN A 1 296 ? 103.826 116.765 82.113  1.00 379.47 ? 296 GLN A CG    1 
ATOM   1759 C CD    . GLN A 1 296 ? 102.719 116.034 82.849  1.00 379.47 ? 296 GLN A CD    1 
ATOM   1760 O OE1   . GLN A 1 296 ? 101.616 115.868 82.329  1.00 379.47 ? 296 GLN A OE1   1 
ATOM   1761 N NE2   . GLN A 1 296 ? 103.010 115.592 84.068  1.00 379.47 ? 296 GLN A NE2   1 
ATOM   1762 N N     . GLN A 1 297 ? 103.209 119.173 78.297  1.00 388.85 ? 297 GLN A N     1 
ATOM   1763 C CA    . GLN A 1 297 ? 102.677 119.462 76.970  1.00 388.85 ? 297 GLN A CA    1 
ATOM   1764 C C     . GLN A 1 297 ? 103.783 119.869 76.005  1.00 388.85 ? 297 GLN A C     1 
ATOM   1765 O O     . GLN A 1 297 ? 103.818 119.410 74.856  1.00 388.85 ? 297 GLN A O     1 
ATOM   1766 C CB    . GLN A 1 297 ? 101.612 120.554 77.065  1.00 388.85 ? 297 GLN A CB    1 
ATOM   1767 C CG    . GLN A 1 297 ? 100.487 120.230 78.035  1.00 388.85 ? 297 GLN A CG    1 
ATOM   1768 C CD    . GLN A 1 297 ? 99.555  121.404 78.257  1.00 388.85 ? 297 GLN A CD    1 
ATOM   1769 O OE1   . GLN A 1 297 ? 99.774  122.495 77.733  1.00 388.85 ? 297 GLN A OE1   1 
ATOM   1770 N NE2   . GLN A 1 297 ? 98.504  121.184 79.041  1.00 388.85 ? 297 GLN A NE2   1 
ATOM   1771 N N     . GLN A 1 298 ? 104.696 120.735 76.451  1.00 408.32 ? 298 GLN A N     1 
ATOM   1772 C CA    . GLN A 1 298 ? 105.783 121.174 75.584  1.00 408.32 ? 298 GLN A CA    1 
ATOM   1773 C C     . GLN A 1 298 ? 106.691 120.012 75.199  1.00 408.32 ? 298 GLN A C     1 
ATOM   1774 O O     . GLN A 1 298 ? 107.103 119.893 74.040  1.00 408.32 ? 298 GLN A O     1 
ATOM   1775 C CB    . GLN A 1 298 ? 106.589 122.277 76.268  1.00 408.32 ? 298 GLN A CB    1 
ATOM   1776 C CG    . GLN A 1 298 ? 105.784 123.511 76.622  1.00 408.32 ? 298 GLN A CG    1 
ATOM   1777 C CD    . GLN A 1 298 ? 106.657 124.650 77.107  1.00 408.32 ? 298 GLN A CD    1 
ATOM   1778 O OE1   . GLN A 1 298 ? 107.867 124.656 76.886  1.00 408.32 ? 298 GLN A OE1   1 
ATOM   1779 N NE2   . GLN A 1 298 ? 106.045 125.622 77.776  1.00 408.32 ? 298 GLN A NE2   1 
ATOM   1780 N N     . VAL A 1 299 ? 107.015 119.148 76.163  1.00 366.36 ? 299 VAL A N     1 
ATOM   1781 C CA    . VAL A 1 299 ? 107.868 117.999 75.878  1.00 366.36 ? 299 VAL A CA    1 
ATOM   1782 C C     . VAL A 1 299 ? 107.176 117.056 74.900  1.00 366.36 ? 299 VAL A C     1 
ATOM   1783 O O     . VAL A 1 299 ? 107.804 116.528 73.974  1.00 366.36 ? 299 VAL A O     1 
ATOM   1784 C CB    . VAL A 1 299 ? 108.256 117.282 77.183  1.00 366.36 ? 299 VAL A CB    1 
ATOM   1785 C CG1   . VAL A 1 299 ? 109.028 116.008 76.879  1.00 366.36 ? 299 VAL A CG1   1 
ATOM   1786 C CG2   . VAL A 1 299 ? 109.085 118.204 78.063  1.00 366.36 ? 299 VAL A CG2   1 
ATOM   1787 N N     . LEU A 1 300 ? 105.876 116.823 75.095  1.00 338.65 ? 300 LEU A N     1 
ATOM   1788 C CA    . LEU A 1 300 ? 105.133 115.963 74.179  1.00 338.65 ? 300 LEU A CA    1 
ATOM   1789 C C     . LEU A 1 300 ? 105.126 116.540 72.769  1.00 338.65 ? 300 LEU A C     1 
ATOM   1790 O O     . LEU A 1 300 ? 105.317 115.814 71.786  1.00 338.65 ? 300 LEU A O     1 
ATOM   1791 C CB    . LEU A 1 300 ? 103.703 115.770 74.688  1.00 338.65 ? 300 LEU A CB    1 
ATOM   1792 C CG    . LEU A 1 300 ? 102.746 115.040 73.744  1.00 338.65 ? 300 LEU A CG    1 
ATOM   1793 C CD1   . LEU A 1 300 ? 103.247 113.634 73.450  1.00 338.65 ? 300 LEU A CD1   1 
ATOM   1794 C CD2   . LEU A 1 300 ? 101.342 115.005 74.324  1.00 338.65 ? 300 LEU A CD2   1 
ATOM   1795 N N     . LYS A 1 301 ? 104.907 117.852 72.651  1.00 329.76 ? 301 LYS A N     1 
ATOM   1796 C CA    . LYS A 1 301 ? 104.909 118.485 71.336  1.00 329.76 ? 301 LYS A CA    1 
ATOM   1797 C C     . LYS A 1 301 ? 106.280 118.391 70.679  1.00 329.76 ? 301 LYS A C     1 
ATOM   1798 O O     . LYS A 1 301 ? 106.381 118.144 69.472  1.00 329.76 ? 301 LYS A O     1 
ATOM   1799 C CB    . LYS A 1 301 ? 104.464 119.942 71.456  1.00 329.76 ? 301 LYS A CB    1 
ATOM   1800 C CG    . LYS A 1 301 ? 103.007 120.105 71.857  1.00 329.76 ? 301 LYS A CG    1 
ATOM   1801 C CD    . LYS A 1 301 ? 102.636 121.568 72.023  1.00 329.76 ? 301 LYS A CD    1 
ATOM   1802 C CE    . LYS A 1 301 ? 101.183 121.720 72.440  1.00 329.76 ? 301 LYS A CE    1 
ATOM   1803 N NZ    . LYS A 1 301 ? 100.804 123.146 72.628  1.00 329.76 ? 301 LYS A NZ    1 
ATOM   1804 N N     . ALA A 1 302 ? 107.347 118.588 71.456  1.00 304.98 ? 302 ALA A N     1 
ATOM   1805 C CA    . ALA A 1 302 ? 108.692 118.465 70.901  1.00 304.98 ? 302 ALA A CA    1 
ATOM   1806 C C     . ALA A 1 302 ? 108.965 117.043 70.429  1.00 304.98 ? 302 ALA A C     1 
ATOM   1807 O O     . ALA A 1 302 ? 109.534 116.838 69.350  1.00 304.98 ? 302 ALA A O     1 
ATOM   1808 C CB    . ALA A 1 302 ? 109.731 118.893 71.934  1.00 304.98 ? 302 ALA A CB    1 
ATOM   1809 N N     . LEU A 1 303 ? 108.565 116.048 71.223  1.00 318.70 ? 303 LEU A N     1 
ATOM   1810 C CA    . LEU A 1 303 ? 108.774 114.657 70.831  1.00 318.70 ? 303 LEU A CA    1 
ATOM   1811 C C     . LEU A 1 303 ? 107.997 114.316 69.567  1.00 318.70 ? 303 LEU A C     1 
ATOM   1812 O O     . LEU A 1 303 ? 108.509 113.619 68.683  1.00 318.70 ? 303 LEU A O     1 
ATOM   1813 C CB    . LEU A 1 303 ? 108.374 113.722 71.972  1.00 318.70 ? 303 LEU A CB    1 
ATOM   1814 C CG    . LEU A 1 303 ? 109.237 113.771 73.232  1.00 318.70 ? 303 LEU A CG    1 
ATOM   1815 C CD1   . LEU A 1 303 ? 108.700 112.811 74.281  1.00 318.70 ? 303 LEU A CD1   1 
ATOM   1816 C CD2   . LEU A 1 303 ? 110.688 113.457 72.904  1.00 318.70 ? 303 LEU A CD2   1 
ATOM   1817 N N     . GLN A 1 304 ? 106.755 114.794 69.465  1.00 325.62 ? 304 GLN A N     1 
ATOM   1818 C CA    . GLN A 1 304 ? 105.983 114.580 68.248  1.00 325.62 ? 304 GLN A CA    1 
ATOM   1819 C C     . GLN A 1 304 ? 106.647 115.252 67.053  1.00 325.62 ? 304 GLN A C     1 
ATOM   1820 O O     . GLN A 1 304 ? 106.689 114.683 65.955  1.00 325.62 ? 304 GLN A O     1 
ATOM   1821 C CB    . GLN A 1 304 ? 104.556 115.092 68.437  1.00 325.62 ? 304 GLN A CB    1 
ATOM   1822 C CG    . GLN A 1 304 ? 103.751 114.300 69.456  1.00 325.62 ? 304 GLN A CG    1 
ATOM   1823 C CD    . GLN A 1 304 ? 102.432 114.963 69.799  1.00 325.62 ? 304 GLN A CD    1 
ATOM   1824 O OE1   . GLN A 1 304 ? 102.147 116.073 69.350  1.00 325.62 ? 304 GLN A OE1   1 
ATOM   1825 N NE2   . GLN A 1 304 ? 101.618 114.284 70.601  1.00 325.62 ? 304 GLN A NE2   1 
ATOM   1826 N N     . LYS A 1 305 ? 107.167 116.467 67.248  1.00 344.44 ? 305 LYS A N     1 
ATOM   1827 C CA    . LYS A 1 305 ? 107.910 117.166 66.209  1.00 344.44 ? 305 LYS A CA    1 
ATOM   1828 C C     . LYS A 1 305 ? 109.194 116.420 65.865  1.00 344.44 ? 305 LYS A C     1 
ATOM   1829 O O     . LYS A 1 305 ? 109.556 116.305 64.692  1.00 344.44 ? 305 LYS A O     1 
ATOM   1830 C CB    . LYS A 1 305 ? 108.234 118.598 66.668  1.00 344.44 ? 305 LYS A CB    1 
ATOM   1831 C CG    . LYS A 1 305 ? 109.036 119.404 65.664  1.00 344.44 ? 305 LYS A CG    1 
ATOM   1832 C CD    . LYS A 1 305 ? 109.334 120.793 66.195  1.00 344.44 ? 305 LYS A CD    1 
ATOM   1833 C CE    . LYS A 1 305 ? 110.084 121.623 65.169  1.00 344.44 ? 305 LYS A CE    1 
ATOM   1834 N NZ    . LYS A 1 305 ? 110.374 122.986 65.683  1.00 344.44 ? 305 LYS A NZ    1 
ATOM   1835 N N     . ASN A 1 306 ? 109.883 115.911 66.886  1.00 366.85 ? 306 ASN A N     1 
ATOM   1836 C CA    . ASN A 1 306 ? 111.102 115.143 66.675  1.00 366.85 ? 306 ASN A CA    1 
ATOM   1837 C C     . ASN A 1 306 ? 110.797 113.781 66.065  1.00 366.85 ? 306 ASN A C     1 
ATOM   1838 O O     . ASN A 1 306 ? 111.713 113.056 65.664  1.00 366.85 ? 306 ASN A O     1 
ATOM   1839 C CB    . ASN A 1 306 ? 111.864 114.979 67.993  1.00 366.85 ? 306 ASN A CB    1 
ATOM   1840 C CG    . ASN A 1 306 ? 112.409 116.290 68.522  1.00 366.85 ? 306 ASN A CG    1 
ATOM   1841 O OD1   . ASN A 1 306 ? 112.017 117.368 68.067  1.00 366.85 ? 306 ASN A OD1   1 
ATOM   1842 N ND2   . ASN A 1 306 ? 113.314 116.208 69.485  1.00 366.85 ? 306 ASN A ND2   1 
ATOM   1843 N N     . ASN A 1 307 ? 109.512 113.423 66.007  1.00 391.44 ? 307 ASN A N     1 
ATOM   1844 C CA    . ASN A 1 307 ? 109.058 112.174 65.392  1.00 391.44 ? 307 ASN A CA    1 
ATOM   1845 C C     . ASN A 1 307 ? 109.625 110.957 66.122  1.00 391.44 ? 307 ASN A C     1 
ATOM   1846 O O     . ASN A 1 307 ? 110.156 110.027 65.509  1.00 391.44 ? 307 ASN A O     1 
ATOM   1847 C CB    . ASN A 1 307 ? 109.406 112.131 63.900  1.00 391.44 ? 307 ASN A CB    1 
ATOM   1848 C CG    . ASN A 1 307 ? 108.694 111.013 63.164  1.00 391.44 ? 307 ASN A CG    1 
ATOM   1849 O OD1   . ASN A 1 307 ? 107.646 110.536 63.599  1.00 391.44 ? 307 ASN A OD1   1 
ATOM   1850 N ND2   . ASN A 1 307 ? 109.263 110.589 62.042  1.00 391.44 ? 307 ASN A ND2   1 
ATOM   1851 N N     . VAL A 1 308 ? 109.517 110.964 67.449  1.00 426.42 ? 308 VAL A N     1 
ATOM   1852 C CA    . VAL A 1 308 ? 109.995 109.846 68.252  1.00 426.42 ? 308 VAL A CA    1 
ATOM   1853 C C     . VAL A 1 308 ? 109.011 108.691 68.122  1.00 426.42 ? 308 VAL A C     1 
ATOM   1854 O O     . VAL A 1 308 ? 107.852 108.796 68.539  1.00 426.42 ? 308 VAL A O     1 
ATOM   1855 C CB    . VAL A 1 308 ? 110.178 110.261 69.717  1.00 426.42 ? 308 VAL A CB    1 
ATOM   1856 C CG1   . VAL A 1 308 ? 110.789 109.123 70.518  1.00 426.42 ? 308 VAL A CG1   1 
ATOM   1857 C CG2   . VAL A 1 308 ? 111.036 111.512 69.803  1.00 426.42 ? 308 VAL A CG2   1 
ATOM   1858 N N     . ARG A 1 309 ? 109.471 107.584 67.546  1.00 429.25 ? 309 ARG A N     1 
ATOM   1859 C CA    . ARG A 1 309 ? 108.629 106.425 67.296  1.00 429.25 ? 309 ARG A CA    1 
ATOM   1860 C C     . ARG A 1 309 ? 109.312 105.168 67.812  1.00 429.25 ? 309 ARG A C     1 
ATOM   1861 O O     . ARG A 1 309 ? 110.543 105.072 67.805  1.00 429.25 ? 309 ARG A O     1 
ATOM   1862 C CB    . ARG A 1 309 ? 108.319 106.278 65.803  1.00 429.25 ? 309 ARG A CB    1 
ATOM   1863 C CG    . ARG A 1 309 ? 107.569 107.461 65.215  1.00 429.25 ? 309 ARG A CG    1 
ATOM   1864 C CD    . ARG A 1 309 ? 107.321 107.281 63.730  1.00 429.25 ? 309 ARG A CD    1 
ATOM   1865 N NE    . ARG A 1 309 ? 106.583 108.405 63.170  1.00 429.25 ? 309 ARG A NE    1 
ATOM   1866 C CZ    . ARG A 1 309 ? 105.260 108.483 63.123  1.00 429.25 ? 309 ARG A CZ    1 
ATOM   1867 N NH1   . ARG A 1 309 ? 104.691 109.563 62.594  1.00 429.25 ? 309 ARG A NH1   1 
ATOM   1868 N NH2   . ARG A 1 309 ? 104.494 107.513 63.594  1.00 429.25 ? 309 ARG A NH2   1 
ATOM   1869 N N     . ASP A 1 310 ? 108.506 104.203 68.245  1.00 447.60 ? 310 ASP A N     1 
ATOM   1870 C CA    . ASP A 1 310 ? 109.037 102.968 68.795  1.00 447.60 ? 310 ASP A CA    1 
ATOM   1871 C C     . ASP A 1 310 ? 109.463 102.028 67.669  1.00 447.60 ? 310 ASP A C     1 
ATOM   1872 O O     . ASP A 1 310 ? 109.551 102.409 66.497  1.00 447.60 ? 310 ASP A O     1 
ATOM   1873 C CB    . ASP A 1 310 ? 108.002 102.304 69.701  1.00 447.60 ? 310 ASP A CB    1 
ATOM   1874 C CG    . ASP A 1 310 ? 106.659 102.123 69.021  1.00 447.60 ? 310 ASP A CG    1 
ATOM   1875 O OD1   . ASP A 1 310 ? 106.504 102.584 67.871  1.00 447.60 ? 310 ASP A OD1   1 
ATOM   1876 O OD2   . ASP A 1 310 ? 105.759 101.516 69.636  1.00 447.60 ? 310 ASP A OD2   1 
ATOM   1877 N N     . ILE A 1 311 ? 109.741 100.778 68.041  1.00 483.00 ? 311 ILE A N     1 
ATOM   1878 C CA    . ILE A 1 311 ? 110.118 99.774  67.051  1.00 483.00 ? 311 ILE A CA    1 
ATOM   1879 C C     . ILE A 1 311 ? 108.972 99.517  66.080  1.00 483.00 ? 311 ILE A C     1 
ATOM   1880 O O     . ILE A 1 311 ? 109.201 99.223  64.901  1.00 483.00 ? 311 ILE A O     1 
ATOM   1881 C CB    . ILE A 1 311 ? 110.567 98.482  67.756  1.00 483.00 ? 311 ILE A CB    1 
ATOM   1882 C CG1   . ILE A 1 311 ? 111.636 98.795  68.805  1.00 483.00 ? 311 ILE A CG1   1 
ATOM   1883 C CG2   . ILE A 1 311 ? 111.094 97.473  66.749  1.00 483.00 ? 311 ILE A CG2   1 
ATOM   1884 C CD1   . ILE A 1 311 ? 112.122 97.585  69.565  1.00 483.00 ? 311 ILE A CD1   1 
ATOM   1885 N N     . SER A 1 312 ? 107.731 99.643  66.545  1.00 452.28 ? 312 SER A N     1 
ATOM   1886 C CA    . SER A 1 312 ? 106.557 99.455  65.702  1.00 452.28 ? 312 SER A CA    1 
ATOM   1887 C C     . SER A 1 312 ? 106.202 100.699 64.897  1.00 452.28 ? 312 SER A C     1 
ATOM   1888 O O     . SER A 1 312 ? 105.105 100.756 64.331  1.00 452.28 ? 312 SER A O     1 
ATOM   1889 C CB    . SER A 1 312 ? 105.356 99.036  66.556  1.00 452.28 ? 312 SER A CB    1 
ATOM   1890 O OG    . SER A 1 312 ? 105.620 97.823  67.243  1.00 452.28 ? 312 SER A OG    1 
ATOM   1891 N N     . ASN A 1 313 ? 107.091 101.694 64.849  1.00 469.80 ? 313 ASN A N     1 
ATOM   1892 C CA    . ASN A 1 313 ? 106.920 102.929 64.091  1.00 469.80 ? 313 ASN A CA    1 
ATOM   1893 C C     . ASN A 1 313 ? 105.746 103.765 64.589  1.00 469.80 ? 313 ASN A C     1 
ATOM   1894 O O     . ASN A 1 313 ? 105.274 104.655 63.877  1.00 469.80 ? 313 ASN A O     1 
ATOM   1895 C CB    . ASN A 1 313 ? 106.761 102.654 62.591  1.00 469.80 ? 313 ASN A CB    1 
ATOM   1896 C CG    . ASN A 1 313 ? 107.215 103.817 61.733  1.00 469.80 ? 313 ASN A CG    1 
ATOM   1897 O OD1   . ASN A 1 313 ? 108.104 104.577 62.116  1.00 469.80 ? 313 ASN A OD1   1 
ATOM   1898 N ND2   . ASN A 1 313 ? 106.607 103.961 60.561  1.00 469.80 ? 313 ASN A ND2   1 
ATOM   1899 N N     . LYS A 1 314 ? 105.263 103.505 65.801  1.00 446.57 ? 314 LYS A N     1 
ATOM   1900 C CA    . LYS A 1 314 ? 104.144 104.255 66.353  1.00 446.57 ? 314 LYS A CA    1 
ATOM   1901 C C     . LYS A 1 314 ? 104.653 105.484 67.094  1.00 446.57 ? 314 LYS A C     1 
ATOM   1902 O O     . LYS A 1 314 ? 105.552 105.386 67.936  1.00 446.57 ? 314 LYS A O     1 
ATOM   1903 C CB    . LYS A 1 314 ? 103.323 103.371 67.288  1.00 446.57 ? 314 LYS A CB    1 
ATOM   1904 C CG    . LYS A 1 314 ? 102.132 104.069 67.921  1.00 446.57 ? 314 LYS A CG    1 
ATOM   1905 C CD    . LYS A 1 314 ? 101.365 103.124 68.830  1.00 446.57 ? 314 LYS A CD    1 
ATOM   1906 C CE    . LYS A 1 314 ? 100.169 103.815 69.461  1.00 446.57 ? 314 LYS A CE    1 
ATOM   1907 N NZ    . LYS A 1 314 ? 99.402  102.899 70.349  1.00 446.57 ? 314 LYS A NZ    1 
ATOM   1908 N N     . LEU A 1 315 ? 104.077 106.641 66.778  1.00 429.23 ? 315 LEU A N     1 
ATOM   1909 C CA    . LEU A 1 315 ? 104.465 107.879 67.438  1.00 429.23 ? 315 LEU A CA    1 
ATOM   1910 C C     . LEU A 1 315 ? 104.063 107.849 68.909  1.00 429.23 ? 315 LEU A C     1 
ATOM   1911 O O     . LEU A 1 315 ? 103.038 107.272 69.285  1.00 429.23 ? 315 LEU A O     1 
ATOM   1912 C CB    . LEU A 1 315 ? 103.824 109.079 66.740  1.00 429.23 ? 315 LEU A CB    1 
ATOM   1913 C CG    . LEU A 1 315 ? 104.274 110.473 67.189  1.00 429.23 ? 315 LEU A CG    1 
ATOM   1914 C CD1   . LEU A 1 315 ? 105.753 110.683 66.900  1.00 429.23 ? 315 LEU A CD1   1 
ATOM   1915 C CD2   . LEU A 1 315 ? 103.436 111.551 66.522  1.00 429.23 ? 315 LEU A CD2   1 
ATOM   1916 N N     . ILE A 1 316 ? 104.892 108.474 69.748  1.00 468.68 ? 316 ILE A N     1 
ATOM   1917 C CA    . ILE A 1 316 ? 104.627 108.491 71.180  1.00 468.68 ? 316 ILE A CA    1 
ATOM   1918 C C     . ILE A 1 316 ? 103.380 109.319 71.467  1.00 468.68 ? 316 ILE A C     1 
ATOM   1919 O O     . ILE A 1 316 ? 103.189 110.412 70.918  1.00 468.68 ? 316 ILE A O     1 
ATOM   1920 C CB    . ILE A 1 316 ? 105.853 109.021 71.943  1.00 468.68 ? 316 ILE A CB    1 
ATOM   1921 C CG1   . ILE A 1 316 ? 105.550 109.134 73.439  1.00 468.68 ? 316 ILE A CG1   1 
ATOM   1922 C CG2   . ILE A 1 316 ? 106.315 110.356 71.370  1.00 468.68 ? 316 ILE A CG2   1 
ATOM   1923 C CD1   . ILE A 1 316 ? 106.735 109.574 74.271  1.00 468.68 ? 316 ILE A CD1   1 
ATOM   1924 N N     . GLU A 1 317 ? 102.515 108.790 72.333  1.00 551.20 ? 317 GLU A N     1 
ATOM   1925 C CA    . GLU A 1 317 ? 101.240 109.421 72.648  1.00 551.20 ? 317 GLU A CA    1 
ATOM   1926 C C     . GLU A 1 317 ? 101.184 110.052 74.029  1.00 551.20 ? 317 GLU A C     1 
ATOM   1927 O O     . GLU A 1 317 ? 100.462 111.033 74.213  1.00 551.20 ? 317 GLU A O     1 
ATOM   1928 C CB    . GLU A 1 317 ? 100.100 108.399 72.528  1.00 551.20 ? 317 GLU A CB    1 
ATOM   1929 C CG    . GLU A 1 317 ? 99.947  107.798 71.142  1.00 551.20 ? 317 GLU A CG    1 
ATOM   1930 C CD    . GLU A 1 317 ? 98.862  106.740 71.083  1.00 551.20 ? 317 GLU A CD    1 
ATOM   1931 O OE1   . GLU A 1 317 ? 98.490  106.208 72.150  1.00 551.20 ? 317 GLU A OE1   1 
ATOM   1932 O OE2   . GLU A 1 317 ? 98.378  106.444 69.971  1.00 551.20 ? 317 GLU A OE2   1 
ATOM   1933 N N     . ASN A 1 318 ? 101.927 109.523 75.000  1.00 566.97 ? 318 ASN A N     1 
ATOM   1934 C CA    . ASN A 1 318 ? 101.899 110.051 76.356  1.00 566.97 ? 318 ASN A CA    1 
ATOM   1935 C C     . ASN A 1 318 ? 103.287 109.920 76.965  1.00 566.97 ? 318 ASN A C     1 
ATOM   1936 O O     . ASN A 1 318 ? 104.134 109.163 76.481  1.00 566.97 ? 318 ASN A O     1 
ATOM   1937 C CB    . ASN A 1 318 ? 100.849 109.337 77.216  1.00 566.97 ? 318 ASN A CB    1 
ATOM   1938 C CG    . ASN A 1 318 ? 101.175 107.876 77.440  1.00 566.97 ? 318 ASN A CG    1 
ATOM   1939 O OD1   . ASN A 1 318 ? 101.812 107.517 78.429  1.00 566.97 ? 318 ASN A OD1   1 
ATOM   1940 N ND2   . ASN A 1 318 ? 100.734 107.024 76.523  1.00 566.97 ? 318 ASN A ND2   1 
ATOM   1941 N N     . THR A 1 319 ? 103.511 110.671 78.045  1.00 550.83 ? 319 THR A N     1 
ATOM   1942 C CA    . THR A 1 319 ? 104.828 110.793 78.657  1.00 550.83 ? 319 THR A CA    1 
ATOM   1943 C C     . THR A 1 319 ? 104.965 109.966 79.932  1.00 550.83 ? 319 THR A C     1 
ATOM   1944 O O     . THR A 1 319 ? 105.904 110.180 80.706  1.00 550.83 ? 319 THR A O     1 
ATOM   1945 C CB    . THR A 1 319 ? 105.138 112.262 78.949  1.00 550.83 ? 319 THR A CB    1 
ATOM   1946 O OG1   . THR A 1 319 ? 104.196 112.772 79.901  1.00 550.83 ? 319 THR A OG1   1 
ATOM   1947 C CG2   . THR A 1 319 ? 105.057 113.085 77.674  1.00 550.83 ? 319 THR A CG2   1 
ATOM   1948 N N     . SER A 1 320 ? 104.047 109.034 80.172  1.00 484.32 ? 320 SER A N     1 
ATOM   1949 C CA    . SER A 1 320 ? 104.182 108.146 81.318  1.00 484.32 ? 320 SER A CA    1 
ATOM   1950 C C     . SER A 1 320 ? 105.404 107.252 81.149  1.00 484.32 ? 320 SER A C     1 
ATOM   1951 O O     . SER A 1 320 ? 105.741 106.826 80.040  1.00 484.32 ? 320 SER A O     1 
ATOM   1952 C CB    . SER A 1 320 ? 102.922 107.296 81.491  1.00 484.32 ? 320 SER A CB    1 
ATOM   1953 O OG    . SER A 1 320 ? 102.693 106.489 80.349  1.00 484.32 ? 320 SER A OG    1 
ATOM   1954 N N     . ASP A 1 321 ? 106.074 106.970 82.270  1.00 482.19 ? 321 ASP A N     1 
ATOM   1955 C CA    . ASP A 1 321 ? 107.312 106.199 82.217  1.00 482.19 ? 321 ASP A CA    1 
ATOM   1956 C C     . ASP A 1 321 ? 107.078 104.810 81.634  1.00 482.19 ? 321 ASP A C     1 
ATOM   1957 O O     . ASP A 1 321 ? 107.942 104.270 80.931  1.00 482.19 ? 321 ASP A O     1 
ATOM   1958 C CB    . ASP A 1 321 ? 107.927 106.096 83.613  1.00 482.19 ? 321 ASP A CB    1 
ATOM   1959 C CG    . ASP A 1 321 ? 109.298 105.451 83.599  1.00 482.19 ? 321 ASP A CG    1 
ATOM   1960 O OD1   . ASP A 1 321 ? 110.256 106.101 83.130  1.00 482.19 ? 321 ASP A OD1   1 
ATOM   1961 O OD2   . ASP A 1 321 ? 109.419 104.295 84.051  1.00 482.19 ? 321 ASP A OD2   1 
ATOM   1962 N N     . SER A 1 322 ? 105.915 104.215 81.915  1.00 473.13 ? 322 SER A N     1 
ATOM   1963 C CA    . SER A 1 322 ? 105.592 102.917 81.331  1.00 473.13 ? 322 SER A CA    1 
ATOM   1964 C C     . SER A 1 322 ? 105.544 102.996 79.810  1.00 473.13 ? 322 SER A C     1 
ATOM   1965 O O     . SER A 1 322 ? 106.057 102.109 79.118  1.00 473.13 ? 322 SER A O     1 
ATOM   1966 C CB    . SER A 1 322 ? 104.260 102.410 81.884  1.00 473.13 ? 322 SER A CB    1 
ATOM   1967 O OG    . SER A 1 322 ? 103.205 103.301 81.565  1.00 473.13 ? 322 SER A OG    1 
ATOM   1968 N N     . ASN A 1 323 ? 104.931 104.052 79.273  1.00 483.65 ? 323 ASN A N     1 
ATOM   1969 C CA    . ASN A 1 323 ? 104.955 104.259 77.829  1.00 483.65 ? 323 ASN A CA    1 
ATOM   1970 C C     . ASN A 1 323 ? 106.358 104.607 77.350  1.00 483.65 ? 323 ASN A C     1 
ATOM   1971 O O     . ASN A 1 323 ? 106.763 104.204 76.253  1.00 483.65 ? 323 ASN A O     1 
ATOM   1972 C CB    . ASN A 1 323 ? 103.966 105.354 77.436  1.00 483.65 ? 323 ASN A CB    1 
ATOM   1973 C CG    . ASN A 1 323 ? 103.874 105.545 75.936  1.00 483.65 ? 323 ASN A CG    1 
ATOM   1974 O OD1   . ASN A 1 323 ? 104.094 104.612 75.163  1.00 483.65 ? 323 ASN A OD1   1 
ATOM   1975 N ND2   . ASN A 1 323 ? 103.549 106.760 75.512  1.00 483.65 ? 323 ASN A ND2   1 
ATOM   1976 N N     . LEU A 1 324 ? 107.113 105.354 78.161  1.00 471.94 ? 324 LEU A N     1 
ATOM   1977 C CA    . LEU A 1 324 ? 108.481 105.707 77.792  1.00 471.94 ? 324 LEU A CA    1 
ATOM   1978 C C     . LEU A 1 324 ? 109.365 104.475 77.659  1.00 471.94 ? 324 LEU A C     1 
ATOM   1979 O O     . LEU A 1 324 ? 110.339 104.489 76.898  1.00 471.94 ? 324 LEU A O     1 
ATOM   1980 C CB    . LEU A 1 324 ? 109.067 106.676 78.819  1.00 471.94 ? 324 LEU A CB    1 
ATOM   1981 C CG    . LEU A 1 324 ? 108.434 108.069 78.874  1.00 471.94 ? 324 LEU A CG    1 
ATOM   1982 C CD1   . LEU A 1 324 ? 109.043 108.904 79.990  1.00 471.94 ? 324 LEU A CD1   1 
ATOM   1983 C CD2   . LEU A 1 324 ? 108.577 108.773 77.536  1.00 471.94 ? 324 LEU A CD2   1 
ATOM   1984 N N     . LYS A 1 325 ? 109.044 103.402 78.384  1.00 475.48 ? 325 LYS A N     1 
ATOM   1985 C CA    . LYS A 1 325 ? 109.820 102.171 78.279  1.00 475.48 ? 325 LYS A CA    1 
ATOM   1986 C C     . LYS A 1 325 ? 109.769 101.567 76.880  1.00 475.48 ? 325 LYS A C     1 
ATOM   1987 O O     . LYS A 1 325 ? 110.661 100.791 76.522  1.00 475.48 ? 325 LYS A O     1 
ATOM   1988 C CB    . LYS A 1 325 ? 109.326 101.144 79.297  1.00 475.48 ? 325 LYS A CB    1 
ATOM   1989 C CG    . LYS A 1 325 ? 109.554 101.540 80.744  1.00 475.48 ? 325 LYS A CG    1 
ATOM   1990 C CD    . LYS A 1 325 ? 109.062 100.463 81.695  1.00 475.48 ? 325 LYS A CD    1 
ATOM   1991 C CE    . LYS A 1 325 ? 109.330 100.842 83.142  1.00 475.48 ? 325 LYS A CE    1 
ATOM   1992 N NZ    . LYS A 1 325 ? 108.886 99.777  84.083  1.00 475.48 ? 325 LYS A NZ    1 
ATOM   1993 N N     . ASN A 1 326 ? 108.752 101.901 76.089  1.00 469.35 ? 326 ASN A N     1 
ATOM   1994 C CA    . ASN A 1 326 ? 108.602 101.349 74.748  1.00 469.35 ? 326 ASN A CA    1 
ATOM   1995 C C     . ASN A 1 326 ? 109.393 102.113 73.694  1.00 469.35 ? 326 ASN A C     1 
ATOM   1996 O O     . ASN A 1 326 ? 109.404 101.694 72.531  1.00 469.35 ? 326 ASN A O     1 
ATOM   1997 C CB    . ASN A 1 326 ? 107.124 101.324 74.359  1.00 469.35 ? 326 ASN A CB    1 
ATOM   1998 C CG    . ASN A 1 326 ? 106.251 100.699 75.428  1.00 469.35 ? 326 ASN A CG    1 
ATOM   1999 O OD1   . ASN A 1 326 ? 106.694 99.827  76.175  1.00 469.35 ? 326 ASN A OD1   1 
ATOM   2000 N ND2   . ASN A 1 326 ? 105.004 101.146 75.510  1.00 469.35 ? 326 ASN A ND2   1 
ATOM   2001 N N     . PHE A 1 327 ? 110.051 103.210 74.060  1.00 462.71 ? 327 PHE A N     1 
ATOM   2002 C CA    . PHE A 1 327 ? 110.775 104.045 73.110  1.00 462.71 ? 327 PHE A CA    1 
ATOM   2003 C C     . PHE A 1 327 ? 112.242 104.194 73.500  1.00 462.71 ? 327 PHE A C     1 
ATOM   2004 O O     . PHE A 1 327 ? 112.838 105.255 73.306  1.00 462.71 ? 327 PHE A O     1 
ATOM   2005 C CB    . PHE A 1 327 ? 110.111 105.415 72.983  1.00 462.71 ? 327 PHE A CB    1 
ATOM   2006 C CG    . PHE A 1 327 ? 108.688 105.363 72.508  1.00 462.71 ? 327 PHE A CG    1 
ATOM   2007 C CD1   . PHE A 1 327 ? 107.654 105.090 73.391  1.00 462.71 ? 327 PHE A CD1   1 
ATOM   2008 C CD2   . PHE A 1 327 ? 108.376 105.601 71.180  1.00 462.71 ? 327 PHE A CD2   1 
ATOM   2009 C CE1   . PHE A 1 327 ? 106.346 105.043 72.958  1.00 462.71 ? 327 PHE A CE1   1 
ATOM   2010 C CE2   . PHE A 1 327 ? 107.067 105.557 70.742  1.00 462.71 ? 327 PHE A CE2   1 
ATOM   2011 C CZ    . PHE A 1 327 ? 106.050 105.277 71.631  1.00 462.71 ? 327 PHE A CZ    1 
ATOM   2012 N N     . LEU A 1 328 ? 112.836 103.132 74.045  1.00 509.01 ? 328 LEU A N     1 
ATOM   2013 C CA    . LEU A 1 328 ? 114.233 103.184 74.466  1.00 509.01 ? 328 LEU A CA    1 
ATOM   2014 C C     . LEU A 1 328 ? 115.207 103.237 73.300  1.00 509.01 ? 328 LEU A C     1 
ATOM   2015 O O     . LEU A 1 328 ? 116.397 103.479 73.527  1.00 509.01 ? 328 LEU A O     1 
ATOM   2016 C CB    . LEU A 1 328 ? 114.553 101.974 75.353  1.00 509.01 ? 328 LEU A CB    1 
ATOM   2017 C CG    . LEU A 1 328 ? 113.776 101.900 76.667  1.00 509.01 ? 328 LEU A CG    1 
ATOM   2018 C CD1   . LEU A 1 328 ? 114.202 100.689 77.480  1.00 509.01 ? 328 LEU A CD1   1 
ATOM   2019 C CD2   . LEU A 1 328 ? 113.952 103.181 77.472  1.00 509.01 ? 328 LEU A CD2   1 
ATOM   2020 N N     . ASN A 1 329 ? 114.742 103.025 72.071  1.00 484.87 ? 329 ASN A N     1 
ATOM   2021 C CA    . ASN A 1 329 ? 115.593 103.141 70.894  1.00 484.87 ? 329 ASN A CA    1 
ATOM   2022 C C     . ASN A 1 329 ? 115.996 104.578 70.594  1.00 484.87 ? 329 ASN A C     1 
ATOM   2023 O O     . ASN A 1 329 ? 116.879 104.795 69.758  1.00 484.87 ? 329 ASN A O     1 
ATOM   2024 C CB    . ASN A 1 329 ? 114.884 102.542 69.675  1.00 484.87 ? 329 ASN A CB    1 
ATOM   2025 C CG    . ASN A 1 329 ? 113.499 103.124 69.463  1.00 484.87 ? 329 ASN A CG    1 
ATOM   2026 O OD1   . ASN A 1 329 ? 112.794 103.445 70.421  1.00 484.87 ? 329 ASN A OD1   1 
ATOM   2027 N ND2   . ASN A 1 329 ? 113.102 103.266 68.203  1.00 484.87 ? 329 ASN A ND2   1 
ATOM   2028 N N     . HIS A 1 330 ? 115.381 105.552 71.256  1.00 479.92 ? 330 HIS A N     1 
ATOM   2029 C CA    . HIS A 1 330 ? 115.668 106.963 71.053  1.00 479.92 ? 330 HIS A CA    1 
ATOM   2030 C C     . HIS A 1 330 ? 116.387 107.515 72.275  1.00 479.92 ? 330 HIS A C     1 
ATOM   2031 O O     . HIS A 1 330 ? 115.962 107.276 73.410  1.00 479.92 ? 330 HIS A O     1 
ATOM   2032 C CB    . HIS A 1 330 ? 114.381 107.748 70.800  1.00 479.92 ? 330 HIS A CB    1 
ATOM   2033 C CG    . HIS A 1 330 ? 113.645 107.324 69.568  1.00 479.92 ? 330 HIS A CG    1 
ATOM   2034 N ND1   . HIS A 1 330 ? 113.803 107.956 68.354  1.00 479.92 ? 330 HIS A ND1   1 
ATOM   2035 C CD2   . HIS A 1 330 ? 112.741 106.339 69.367  1.00 479.92 ? 330 HIS A CD2   1 
ATOM   2036 C CE1   . HIS A 1 330 ? 113.030 107.374 67.455  1.00 479.92 ? 330 HIS A CE1   1 
ATOM   2037 N NE2   . HIS A 1 330 ? 112.375 106.389 68.043  1.00 479.92 ? 330 HIS A NE2   1 
ATOM   2038 N N     . GLU A 1 331 ? 117.479 108.249 72.040  1.00 580.51 ? 331 GLU A N     1 
ATOM   2039 C CA    . GLU A 1 331 ? 118.216 108.873 73.133  1.00 580.51 ? 331 GLU A CA    1 
ATOM   2040 C C     . GLU A 1 331 ? 117.398 109.929 73.867  1.00 580.51 ? 331 GLU A C     1 
ATOM   2041 O O     . GLU A 1 331 ? 117.727 110.255 75.017  1.00 580.51 ? 331 GLU A O     1 
ATOM   2042 C CB    . GLU A 1 331 ? 119.509 109.494 72.606  1.00 580.51 ? 331 GLU A CB    1 
ATOM   2043 C CG    . GLU A 1 331 ? 120.485 108.485 72.028  1.00 580.51 ? 331 GLU A CG    1 
ATOM   2044 C CD    . GLU A 1 331 ? 121.792 109.116 71.594  1.00 580.51 ? 331 GLU A CD    1 
ATOM   2045 O OE1   . GLU A 1 331 ? 121.934 110.350 71.725  1.00 580.51 ? 331 GLU A OE1   1 
ATOM   2046 O OE2   . GLU A 1 331 ? 122.679 108.372 71.124  1.00 580.51 ? 331 GLU A OE2   1 
ATOM   2047 N N     . GLU A 1 332 ? 116.358 110.474 73.239  1.00 594.52 ? 332 GLU A N     1 
ATOM   2048 C CA    . GLU A 1 332 ? 115.500 111.438 73.913  1.00 594.52 ? 332 GLU A CA    1 
ATOM   2049 C C     . GLU A 1 332 ? 114.752 110.839 75.094  1.00 594.52 ? 332 GLU A C     1 
ATOM   2050 O O     . GLU A 1 332 ? 114.644 111.494 76.132  1.00 594.52 ? 332 GLU A O     1 
ATOM   2051 C CB    . GLU A 1 332 ? 114.496 112.049 72.926  1.00 594.52 ? 332 GLU A CB    1 
ATOM   2052 C CG    . GLU A 1 332 ? 114.017 111.109 71.837  1.00 594.52 ? 332 GLU A CG    1 
ATOM   2053 C CD    . GLU A 1 332 ? 114.875 111.176 70.586  1.00 594.52 ? 332 GLU A CD    1 
ATOM   2054 O OE1   . GLU A 1 332 ? 115.992 111.730 70.661  1.00 594.52 ? 332 GLU A OE1   1 
ATOM   2055 O OE2   . GLU A 1 332 ? 114.431 110.681 69.530  1.00 594.52 ? 332 GLU A OE2   1 
ATOM   2056 N N     . ILE A 1 333 ? 114.242 109.611 74.973  1.00 531.25 ? 333 ILE A N     1 
ATOM   2057 C CA    . ILE A 1 333 ? 113.558 108.978 76.098  1.00 531.25 ? 333 ILE A CA    1 
ATOM   2058 C C     . ILE A 1 333 ? 114.552 108.632 77.201  1.00 531.25 ? 333 ILE A C     1 
ATOM   2059 O O     . ILE A 1 333 ? 114.260 108.783 78.392  1.00 531.25 ? 333 ILE A O     1 
ATOM   2060 C CB    . ILE A 1 333 ? 112.783 107.740 75.617  1.00 531.25 ? 333 ILE A CB    1 
ATOM   2061 C CG1   . ILE A 1 333 ? 111.905 108.110 74.419  1.00 531.25 ? 333 ILE A CG1   1 
ATOM   2062 C CG2   . ILE A 1 333 ? 111.941 107.178 76.741  1.00 531.25 ? 333 ILE A CG2   1 
ATOM   2063 C CD1   . ILE A 1 333 ? 110.892 109.191 74.717  1.00 531.25 ? 333 ILE A CD1   1 
ATOM   2064 N N     . ILE A 1 334 ? 115.747 108.184 76.812  1.00 519.02 ? 334 ILE A N     1 
ATOM   2065 C CA    . ILE A 1 334 ? 116.892 108.073 77.716  1.00 519.02 ? 334 ILE A CA    1 
ATOM   2066 C C     . ILE A 1 334 ? 117.029 109.328 78.570  1.00 519.02 ? 334 ILE A C     1 
ATOM   2067 O O     . ILE A 1 334 ? 116.802 109.301 79.789  1.00 519.02 ? 334 ILE A O     1 
ATOM   2068 C CB    . ILE A 1 334 ? 118.178 107.765 76.928  1.00 519.02 ? 334 ILE A CB    1 
ATOM   2069 C CG1   . ILE A 1 334 ? 118.021 106.443 76.169  1.00 519.02 ? 334 ILE A CG1   1 
ATOM   2070 C CG2   . ILE A 1 334 ? 119.376 107.710 77.861  1.00 519.02 ? 334 ILE A CG2   1 
ATOM   2071 C CD1   . ILE A 1 334 ? 119.173 106.122 75.243  1.00 519.02 ? 334 ILE A CD1   1 
ATOM   2072 N N     . SER A 1 335 ? 117.405 110.440 77.939  1.00 544.17 ? 335 SER A N     1 
ATOM   2073 C CA    . SER A 1 335 ? 117.672 111.686 78.653  1.00 544.17 ? 335 SER A CA    1 
ATOM   2074 C C     . SER A 1 335 ? 116.444 112.169 79.423  1.00 544.17 ? 335 SER A C     1 
ATOM   2075 O O     . SER A 1 335 ? 116.582 112.698 80.530  1.00 544.17 ? 335 SER A O     1 
ATOM   2076 C CB    . SER A 1 335 ? 118.146 112.758 77.673  1.00 544.17 ? 335 SER A CB    1 
ATOM   2077 O OG    . SER A 1 335 ? 118.663 113.884 78.362  1.00 544.17 ? 335 SER A OG    1 
ATOM   2078 N N     . LEU A 1 336 ? 115.245 112.036 78.857  1.00 555.13 ? 336 LEU A N     1 
ATOM   2079 C CA    . LEU A 1 336 ? 114.046 112.510 79.545  1.00 555.13 ? 336 LEU A CA    1 
ATOM   2080 C C     . LEU A 1 336 ? 113.813 111.722 80.830  1.00 555.13 ? 336 LEU A C     1 
ATOM   2081 O O     . LEU A 1 336 ? 113.599 112.312 81.895  1.00 555.13 ? 336 LEU A O     1 
ATOM   2082 C CB    . LEU A 1 336 ? 112.833 112.404 78.622  1.00 555.13 ? 336 LEU A CB    1 
ATOM   2083 C CG    . LEU A 1 336 ? 111.475 112.635 79.290  1.00 555.13 ? 336 LEU A CG    1 
ATOM   2084 C CD1   . LEU A 1 336 ? 111.367 114.058 79.816  1.00 555.13 ? 336 LEU A CD1   1 
ATOM   2085 C CD2   . LEU A 1 336 ? 110.336 112.322 78.332  1.00 555.13 ? 336 LEU A CD2   1 
ATOM   2086 N N     . ARG A 1 337 ? 113.774 110.389 80.741  1.00 456.51 ? 337 ARG A N     1 
ATOM   2087 C CA    . ARG A 1 337 ? 113.571 109.570 81.934  1.00 456.51 ? 337 ARG A CA    1 
ATOM   2088 C C     . ARG A 1 337 ? 114.660 109.849 82.966  1.00 456.51 ? 337 ARG A C     1 
ATOM   2089 O O     . ARG A 1 337 ? 114.390 109.905 84.174  1.00 456.51 ? 337 ARG A O     1 
ATOM   2090 C CB    . ARG A 1 337 ? 113.555 108.092 81.548  1.00 456.51 ? 337 ARG A CB    1 
ATOM   2091 C CG    . ARG A 1 337 ? 112.387 107.704 80.660  1.00 456.51 ? 337 ARG A CG    1 
ATOM   2092 C CD    . ARG A 1 337 ? 112.378 106.214 80.366  1.00 456.51 ? 337 ARG A CD    1 
ATOM   2093 N NE    . ARG A 1 337 ? 112.239 105.409 81.573  1.00 456.51 ? 337 ARG A NE    1 
ATOM   2094 C CZ    . ARG A 1 337 ? 112.196 104.083 81.580  1.00 456.51 ? 337 ARG A CZ    1 
ATOM   2095 N NH1   . ARG A 1 337 ? 112.063 103.446 82.740  1.00 456.51 ? 337 ARG A NH1   1 
ATOM   2096 N NH2   . ARG A 1 337 ? 112.280 103.382 80.462  1.00 456.51 ? 337 ARG A NH2   1 
ATOM   2097 N N     . ASN A 1 338 ? 115.887 110.092 82.496  1.00 427.73 ? 338 ASN A N     1 
ATOM   2098 C CA    . ASN A 1 338 ? 116.998 110.402 83.393  1.00 427.73 ? 338 ASN A CA    1 
ATOM   2099 C C     . ASN A 1 338 ? 116.741 111.715 84.123  1.00 427.73 ? 338 ASN A C     1 
ATOM   2100 O O     . ASN A 1 338 ? 116.863 111.793 85.353  1.00 427.73 ? 338 ASN A O     1 
ATOM   2101 C CB    . ASN A 1 338 ? 118.310 110.461 82.609  1.00 427.73 ? 338 ASN A CB    1 
ATOM   2102 C CG    . ASN A 1 338 ? 118.742 109.103 82.096  1.00 427.73 ? 338 ASN A CG    1 
ATOM   2103 O OD1   . ASN A 1 338 ? 118.181 108.075 82.477  1.00 427.73 ? 338 ASN A OD1   1 
ATOM   2104 N ND2   . ASN A 1 338 ? 119.743 109.092 81.221  1.00 427.73 ? 338 ASN A ND2   1 
ATOM   2105 N N     . TYR A 1 339 ? 116.446 112.773 83.365  1.00 392.68 ? 339 TYR A N     1 
ATOM   2106 C CA    . TYR A 1 339 ? 116.210 114.086 83.952  1.00 392.68 ? 339 TYR A CA    1 
ATOM   2107 C C     . TYR A 1 339 ? 115.045 114.031 84.925  1.00 392.68 ? 339 TYR A C     1 
ATOM   2108 O O     . TYR A 1 339 ? 115.082 114.669 85.977  1.00 392.68 ? 339 TYR A O     1 
ATOM   2109 C CB    . TYR A 1 339 ? 115.953 115.116 82.849  1.00 392.68 ? 339 TYR A CB    1 
ATOM   2110 C CG    . TYR A 1 339 ? 115.582 116.495 83.360  1.00 392.68 ? 339 TYR A CG    1 
ATOM   2111 C CD1   . TYR A 1 339 ? 116.562 117.432 83.663  1.00 392.68 ? 339 TYR A CD1   1 
ATOM   2112 C CD2   . TYR A 1 339 ? 114.254 116.865 83.523  1.00 392.68 ? 339 TYR A CD2   1 
ATOM   2113 C CE1   . TYR A 1 339 ? 116.232 118.689 84.125  1.00 392.68 ? 339 TYR A CE1   1 
ATOM   2114 C CE2   . TYR A 1 339 ? 113.913 118.121 83.986  1.00 392.68 ? 339 TYR A CE2   1 
ATOM   2115 C CZ    . TYR A 1 339 ? 114.906 119.028 84.285  1.00 392.68 ? 339 TYR A CZ    1 
ATOM   2116 O OH    . TYR A 1 339 ? 114.574 120.282 84.744  1.00 392.68 ? 339 TYR A OH    1 
ATOM   2117 N N     . ARG A 1 340 ? 113.989 113.288 84.586  1.00 474.00 ? 340 ARG A N     1 
ATOM   2118 C CA    . ARG A 1 340 ? 112.853 113.179 85.497  1.00 474.00 ? 340 ARG A CA    1 
ATOM   2119 C C     . ARG A 1 340 ? 113.259 112.496 86.797  1.00 474.00 ? 340 ARG A C     1 
ATOM   2120 O O     . ARG A 1 340 ? 112.887 112.952 87.888  1.00 474.00 ? 340 ARG A O     1 
ATOM   2121 C CB    . ARG A 1 340 ? 111.702 112.413 84.845  1.00 474.00 ? 340 ARG A CB    1 
ATOM   2122 C CG    . ARG A 1 340 ? 110.964 113.170 83.769  1.00 474.00 ? 340 ARG A CG    1 
ATOM   2123 C CD    . ARG A 1 340 ? 109.688 112.433 83.410  1.00 474.00 ? 340 ARG A CD    1 
ATOM   2124 N NE    . ARG A 1 340 ? 108.875 113.180 82.461  1.00 474.00 ? 340 ARG A NE    1 
ATOM   2125 C CZ    . ARG A 1 340 ? 107.671 112.807 82.054  1.00 474.00 ? 340 ARG A CZ    1 
ATOM   2126 N NH1   . ARG A 1 340 ? 107.011 113.578 81.195  1.00 474.00 ? 340 ARG A NH1   1 
ATOM   2127 N NH2   . ARG A 1 340 ? 107.104 111.697 82.495  1.00 474.00 ? 340 ARG A NH2   1 
ATOM   2128 N N     . ARG A 1 341 ? 113.954 111.359 86.699  1.00 524.99 ? 341 ARG A N     1 
ATOM   2129 C CA    . ARG A 1 341 ? 114.427 110.674 87.898  1.00 524.99 ? 341 ARG A CA    1 
ATOM   2130 C C     . ARG A 1 341 ? 115.252 111.607 88.779  1.00 524.99 ? 341 ARG A C     1 
ATOM   2131 O O     . ARG A 1 341 ? 114.984 111.750 89.981  1.00 524.99 ? 341 ARG A O     1 
ATOM   2132 C CB    . ARG A 1 341 ? 115.244 109.444 87.497  1.00 524.99 ? 341 ARG A CB    1 
ATOM   2133 C CG    . ARG A 1 341 ? 115.833 108.664 88.660  1.00 524.99 ? 341 ARG A CG    1 
ATOM   2134 C CD    . ARG A 1 341 ? 116.645 107.477 88.160  1.00 524.99 ? 341 ARG A CD    1 
ATOM   2135 N NE    . ARG A 1 341 ? 117.619 107.858 87.144  1.00 524.99 ? 341 ARG A NE    1 
ATOM   2136 C CZ    . ARG A 1 341 ? 118.766 108.475 87.395  1.00 524.99 ? 341 ARG A CZ    1 
ATOM   2137 N NH1   . ARG A 1 341 ? 119.580 108.770 86.384  1.00 524.99 ? 341 ARG A NH1   1 
ATOM   2138 N NH2   . ARG A 1 341 ? 119.120 108.804 88.627  1.00 524.99 ? 341 ARG A NH2   1 
ATOM   2139 N N     . LEU A 1 342 ? 116.243 112.278 88.184  1.00 442.53 ? 342 LEU A N     1 
ATOM   2140 C CA    . LEU A 1 342 ? 117.089 113.191 88.948  1.00 442.53 ? 342 LEU A CA    1 
ATOM   2141 C C     . LEU A 1 342 ? 116.297 114.375 89.487  1.00 442.53 ? 342 LEU A C     1 
ATOM   2142 O O     . LEU A 1 342 ? 116.588 114.878 90.577  1.00 442.53 ? 342 LEU A O     1 
ATOM   2143 C CB    . LEU A 1 342 ? 118.252 113.683 88.083  1.00 442.53 ? 342 LEU A CB    1 
ATOM   2144 C CG    . LEU A 1 342 ? 119.212 112.655 87.488  1.00 442.53 ? 342 LEU A CG    1 
ATOM   2145 C CD1   . LEU A 1 342 ? 120.172 113.331 86.523  1.00 442.53 ? 342 LEU A CD1   1 
ATOM   2146 C CD2   . LEU A 1 342 ? 119.979 111.959 88.597  1.00 442.53 ? 342 LEU A CD2   1 
ATOM   2147 N N     . TYR A 1 343 ? 115.270 114.809 88.758  1.00 438.81 ? 343 TYR A N     1 
ATOM   2148 C CA    . TYR A 1 343 ? 114.469 115.950 89.183  1.00 438.81 ? 343 TYR A CA    1 
ATOM   2149 C C     . TYR A 1 343 ? 113.652 115.611 90.417  1.00 438.81 ? 343 TYR A C     1 
ATOM   2150 O O     . TYR A 1 343 ? 113.596 116.392 91.372  1.00 438.81 ? 343 TYR A O     1 
ATOM   2151 C CB    . TYR A 1 343 ? 113.561 116.410 88.043  1.00 438.81 ? 343 TYR A CB    1 
ATOM   2152 C CG    . TYR A 1 343 ? 112.776 117.661 88.358  1.00 438.81 ? 343 TYR A CG    1 
ATOM   2153 C CD1   . TYR A 1 343 ? 113.318 118.918 88.120  1.00 438.81 ? 343 TYR A CD1   1 
ATOM   2154 C CD2   . TYR A 1 343 ? 111.496 117.591 88.889  1.00 438.81 ? 343 TYR A CD2   1 
ATOM   2155 C CE1   . TYR A 1 343 ? 112.610 120.067 88.407  1.00 438.81 ? 343 TYR A CE1   1 
ATOM   2156 C CE2   . TYR A 1 343 ? 110.777 118.736 89.179  1.00 438.81 ? 343 TYR A CE2   1 
ATOM   2157 C CZ    . TYR A 1 343 ? 111.341 119.971 88.935  1.00 438.81 ? 343 TYR A CZ    1 
ATOM   2158 O OH    . TYR A 1 343 ? 110.633 121.115 89.219  1.00 438.81 ? 343 TYR A OH    1 
ATOM   2159 N N     . LYS A 1 344 ? 112.973 114.464 90.397  1.00 478.60 ? 344 LYS A N     1 
ATOM   2160 C CA    . LYS A 1 344 ? 112.236 114.060 91.587  1.00 478.60 ? 344 LYS A CA    1 
ATOM   2161 C C     . LYS A 1 344 ? 113.182 113.823 92.756  1.00 478.60 ? 344 LYS A C     1 
ATOM   2162 O O     . LYS A 1 344 ? 112.904 114.260 93.878  1.00 478.60 ? 344 LYS A O     1 
ATOM   2163 C CB    . LYS A 1 344 ? 111.399 112.812 91.311  1.00 478.60 ? 344 LYS A CB    1 
ATOM   2164 C CG    . LYS A 1 344 ? 110.591 112.392 92.526  1.00 478.60 ? 344 LYS A CG    1 
ATOM   2165 C CD    . LYS A 1 344 ? 109.673 111.220 92.248  1.00 478.60 ? 344 LYS A CD    1 
ATOM   2166 C CE    . LYS A 1 344 ? 108.927 110.828 93.513  1.00 478.60 ? 344 LYS A CE    1 
ATOM   2167 N NZ    . LYS A 1 344 ? 108.004 109.692 93.283  1.00 478.60 ? 344 LYS A NZ    1 
ATOM   2168 N N     . LEU A 1 345 ? 114.316 113.158 92.511  1.00 460.07 ? 345 LEU A N     1 
ATOM   2169 C CA    . LEU A 1 345 ? 115.292 112.942 93.577  1.00 460.07 ? 345 LEU A CA    1 
ATOM   2170 C C     . LEU A 1 345 ? 115.748 114.261 94.197  1.00 460.07 ? 345 LEU A C     1 
ATOM   2171 O O     . LEU A 1 345 ? 115.843 114.383 95.424  1.00 460.07 ? 345 LEU A O     1 
ATOM   2172 C CB    . LEU A 1 345 ? 116.489 112.160 93.035  1.00 460.07 ? 345 LEU A CB    1 
ATOM   2173 C CG    . LEU A 1 345 ? 116.278 110.676 92.724  1.00 460.07 ? 345 LEU A CG    1 
ATOM   2174 C CD1   . LEU A 1 345 ? 117.470 110.113 91.961  1.00 460.07 ? 345 LEU A CD1   1 
ATOM   2175 C CD2   . LEU A 1 345 ? 116.041 109.891 94.008  1.00 460.07 ? 345 LEU A CD2   1 
ATOM   2176 N N     . TYR A 1 346 ? 116.039 115.258 93.361  1.00 333.96 ? 346 TYR A N     1 
ATOM   2177 C CA    . TYR A 1 346 ? 116.553 116.532 93.852  1.00 333.96 ? 346 TYR A CA    1 
ATOM   2178 C C     . TYR A 1 346 ? 115.464 117.348 94.537  1.00 333.96 ? 346 TYR A C     1 
ATOM   2179 O O     . TYR A 1 346 ? 115.580 117.695 95.718  1.00 333.96 ? 346 TYR A O     1 
ATOM   2180 C CB    . TYR A 1 346 ? 117.170 117.315 92.692  1.00 333.96 ? 346 TYR A CB    1 
ATOM   2181 C CG    . TYR A 1 346 ? 117.710 118.669 93.082  1.00 333.96 ? 346 TYR A CG    1 
ATOM   2182 C CD1   . TYR A 1 346 ? 119.002 118.805 93.570  1.00 333.96 ? 346 TYR A CD1   1 
ATOM   2183 C CD2   . TYR A 1 346 ? 116.932 119.810 92.955  1.00 333.96 ? 346 TYR A CD2   1 
ATOM   2184 C CE1   . TYR A 1 346 ? 119.498 120.039 93.927  1.00 333.96 ? 346 TYR A CE1   1 
ATOM   2185 C CE2   . TYR A 1 346 ? 117.422 121.050 93.309  1.00 333.96 ? 346 TYR A CE2   1 
ATOM   2186 C CZ    . TYR A 1 346 ? 118.707 121.159 93.793  1.00 333.96 ? 346 TYR A CZ    1 
ATOM   2187 O OH    . TYR A 1 346 ? 119.201 122.394 94.149  1.00 333.96 ? 346 TYR A OH    1 
ATOM   2188 N N     . SER A 1 347 ? 114.392 117.664 93.809  1.00 316.19 ? 347 SER A N     1 
ATOM   2189 C CA    . SER A 1 347 ? 113.365 118.553 94.340  1.00 316.19 ? 347 SER A CA    1 
ATOM   2190 C C     . SER A 1 347 ? 112.579 117.886 95.458  1.00 316.19 ? 347 SER A C     1 
ATOM   2191 O O     . SER A 1 347 ? 112.438 118.455 96.546  1.00 316.19 ? 347 SER A O     1 
ATOM   2192 C CB    . SER A 1 347 ? 112.431 119.002 93.217  1.00 316.19 ? 347 SER A CB    1 
ATOM   2193 O OG    . SER A 1 347 ? 111.849 117.887 92.564  1.00 316.19 ? 347 SER A OG    1 
ATOM   2194 N N     . ALA A 1 348 ? 112.065 116.677 95.220  1.00 292.92 ? 348 ALA A N     1 
ATOM   2195 C CA    . ALA A 1 348 ? 111.176 116.058 96.191  1.00 292.92 ? 348 ALA A CA    1 
ATOM   2196 C C     . ALA A 1 348 ? 111.927 115.633 97.445  1.00 292.92 ? 348 ALA A C     1 
ATOM   2197 O O     . ALA A 1 348 ? 111.304 115.405 98.486  1.00 292.92 ? 348 ALA A O     1 
ATOM   2198 C CB    . ALA A 1 348 ? 110.463 114.858 95.568  1.00 292.92 ? 348 ALA A CB    1 
ATOM   2199 N N     . PHE A 1 349 ? 113.251 115.487 97.364  1.00 313.19 ? 349 PHE A N     1 
ATOM   2200 C CA    . PHE A 1 349 ? 114.025 115.051 98.522  1.00 313.19 ? 349 PHE A CA    1 
ATOM   2201 C C     . PHE A 1 349 ? 115.139 116.035 98.853  1.00 313.19 ? 349 PHE A C     1 
ATOM   2202 O O     . PHE A 1 349 ? 115.080 116.675 99.906  1.00 313.19 ? 349 PHE A O     1 
ATOM   2203 C CB    . PHE A 1 349 ? 114.584 113.649 98.278  1.00 313.19 ? 349 PHE A CB    1 
ATOM   2204 C CG    . PHE A 1 349 ? 115.574 113.207 99.313  1.00 313.19 ? 349 PHE A CG    1 
ATOM   2205 C CD1   . PHE A 1 349 ? 115.151 112.748 100.548 1.00 313.19 ? 349 PHE A CD1   1 
ATOM   2206 C CD2   . PHE A 1 349 ? 116.935 113.259 99.051  1.00 313.19 ? 349 PHE A CD2   1 
ATOM   2207 C CE1   . PHE A 1 349 ? 116.067 112.346 101.502 1.00 313.19 ? 349 PHE A CE1   1 
ATOM   2208 C CE2   . PHE A 1 349 ? 117.853 112.860 99.999  1.00 313.19 ? 349 PHE A CE2   1 
ATOM   2209 C CZ    . PHE A 1 349 ? 117.420 112.401 101.226 1.00 313.19 ? 349 PHE A CZ    1 
ATOM   2210 N N     . TYR A 1 350 ? 116.165 116.163 98.004  1.00 289.91 ? 350 TYR A N     1 
ATOM   2211 C CA    . TYR A 1 350 ? 117.303 117.008 98.355  1.00 289.91 ? 350 TYR A CA    1 
ATOM   2212 C C     . TYR A 1 350 ? 116.867 118.433 98.670  1.00 289.91 ? 350 TYR A C     1 
ATOM   2213 O O     . TYR A 1 350 ? 117.515 119.126 99.463  1.00 289.91 ? 350 TYR A O     1 
ATOM   2214 C CB    . TYR A 1 350 ? 118.333 116.993 97.229  1.00 289.91 ? 350 TYR A CB    1 
ATOM   2215 C CG    . TYR A 1 350 ? 119.177 115.745 97.226  1.00 289.91 ? 350 TYR A CG    1 
ATOM   2216 C CD1   . TYR A 1 350 ? 120.187 115.568 98.159  1.00 289.91 ? 350 TYR A CD1   1 
ATOM   2217 C CD2   . TYR A 1 350 ? 118.965 114.744 96.290  1.00 289.91 ? 350 TYR A CD2   1 
ATOM   2218 C CE1   . TYR A 1 350 ? 120.960 114.430 98.165  1.00 289.91 ? 350 TYR A CE1   1 
ATOM   2219 C CE2   . TYR A 1 350 ? 119.736 113.599 96.286  1.00 289.91 ? 350 TYR A CE2   1 
ATOM   2220 C CZ    . TYR A 1 350 ? 120.734 113.449 97.225  1.00 289.91 ? 350 TYR A CZ    1 
ATOM   2221 O OH    . TYR A 1 350 ? 121.507 112.311 97.227  1.00 289.91 ? 350 TYR A OH    1 
ATOM   2222 N N     . LEU A 1 351 ? 115.769 118.883 98.062  1.00 338.97 ? 351 LEU A N     1 
ATOM   2223 C CA    . LEU A 1 351 ? 115.303 120.247 98.280  1.00 338.97 ? 351 LEU A CA    1 
ATOM   2224 C C     . LEU A 1 351 ? 114.286 120.333 99.410  1.00 338.97 ? 351 LEU A C     1 
ATOM   2225 O O     . LEU A 1 351 ? 114.225 121.350 100.108 1.00 338.97 ? 351 LEU A O     1 
ATOM   2226 C CB    . LEU A 1 351 ? 114.712 120.808 96.986  1.00 338.97 ? 351 LEU A CB    1 
ATOM   2227 C CG    . LEU A 1 351 ? 114.395 122.304 96.962  1.00 338.97 ? 351 LEU A CG    1 
ATOM   2228 C CD1   . LEU A 1 351 ? 115.674 123.116 97.069  1.00 338.97 ? 351 LEU A CD1   1 
ATOM   2229 C CD2   . LEU A 1 351 ? 113.634 122.664 95.698  1.00 338.97 ? 351 LEU A CD2   1 
ATOM   2230 N N     . LYS A 1 352 ? 113.489 119.282 99.602  1.00 332.57 ? 352 LYS A N     1 
ATOM   2231 C CA    . LYS A 1 352 ? 112.479 119.250 100.651 1.00 332.57 ? 352 LYS A CA    1 
ATOM   2232 C C     . LYS A 1 352 ? 113.030 118.899 102.024 1.00 332.57 ? 352 LYS A C     1 
ATOM   2233 O O     . LYS A 1 352 ? 112.592 119.488 103.017 1.00 332.57 ? 352 LYS A O     1 
ATOM   2234 C CB    . LYS A 1 352 ? 111.372 118.254 100.289 1.00 332.57 ? 352 LYS A CB    1 
ATOM   2235 C CG    . LYS A 1 352 ? 110.534 118.664 99.088  1.00 332.57 ? 352 LYS A CG    1 
ATOM   2236 C CD    . LYS A 1 352 ? 109.363 117.717 98.883  1.00 332.57 ? 352 LYS A CD    1 
ATOM   2237 C CE    . LYS A 1 352 ? 108.552 118.071 97.650  1.00 332.57 ? 352 LYS A CE    1 
ATOM   2238 N NZ    . LYS A 1 352 ? 107.438 117.106 97.439  1.00 332.57 ? 352 LYS A NZ    1 
ATOM   2239 N N     . LEU A 1 353 ? 113.949 117.937 102.104 1.00 349.60 ? 353 LEU A N     1 
ATOM   2240 C CA    . LEU A 1 353 ? 114.417 117.459 103.405 1.00 349.60 ? 353 LEU A CA    1 
ATOM   2241 C C     . LEU A 1 353 ? 114.899 118.566 104.336 1.00 349.60 ? 353 LEU A C     1 
ATOM   2242 O O     . LEU A 1 353 ? 114.516 118.546 105.519 1.00 349.60 ? 353 LEU A O     1 
ATOM   2243 C CB    . LEU A 1 353 ? 115.511 116.409 103.191 1.00 349.60 ? 353 LEU A CB    1 
ATOM   2244 C CG    . LEU A 1 353 ? 116.024 115.721 104.453 1.00 349.60 ? 353 LEU A CG    1 
ATOM   2245 C CD1   . LEU A 1 353 ? 114.920 114.887 105.087 1.00 349.60 ? 353 LEU A CD1   1 
ATOM   2246 C CD2   . LEU A 1 353 ? 117.235 114.864 104.127 1.00 349.60 ? 353 LEU A CD2   1 
ATOM   2247 N N     . PRO A 1 354 ? 115.728 119.530 103.909 1.00 360.23 ? 354 PRO A N     1 
ATOM   2248 C CA    . PRO A 1 354 ? 116.217 120.532 104.874 1.00 360.23 ? 354 PRO A CA    1 
ATOM   2249 C C     . PRO A 1 354 ? 115.110 121.308 105.569 1.00 360.23 ? 354 PRO A C     1 
ATOM   2250 O O     . PRO A 1 354 ? 115.334 121.855 106.655 1.00 360.23 ? 354 PRO A O     1 
ATOM   2251 C CB    . PRO A 1 354 ? 117.095 121.450 104.013 1.00 360.23 ? 354 PRO A CB    1 
ATOM   2252 C CG    . PRO A 1 354 ? 117.534 120.595 102.882 1.00 360.23 ? 354 PRO A CG    1 
ATOM   2253 C CD    . PRO A 1 354 ? 116.385 119.680 102.595 1.00 360.23 ? 354 PRO A CD    1 
ATOM   2254 N N     . LEU A 1 355 ? 113.918 121.363 104.972 1.00 493.19 ? 355 LEU A N     1 
ATOM   2255 C CA    . LEU A 1 355 ? 112.786 122.092 105.531 1.00 493.19 ? 355 LEU A CA    1 
ATOM   2256 C C     . LEU A 1 355 ? 112.280 121.513 106.845 1.00 493.19 ? 355 LEU A C     1 
ATOM   2257 O O     . LEU A 1 355 ? 111.656 122.246 107.622 1.00 493.19 ? 355 LEU A O     1 
ATOM   2258 C CB    . LEU A 1 355 ? 111.642 122.132 104.517 1.00 493.19 ? 355 LEU A CB    1 
ATOM   2259 C CG    . LEU A 1 355 ? 111.976 122.757 103.161 1.00 493.19 ? 355 LEU A CG    1 
ATOM   2260 C CD1   . LEU A 1 355 ? 110.808 122.612 102.198 1.00 493.19 ? 355 LEU A CD1   1 
ATOM   2261 C CD2   . LEU A 1 355 ? 112.368 124.218 103.326 1.00 493.19 ? 355 LEU A CD2   1 
ATOM   2262 N N     . HIS A 1 356 ? 112.727 120.302 107.197 1.00 422.17 ? 356 HIS A N     1 
ATOM   2263 C CA    . HIS A 1 356 ? 112.340 119.716 108.511 1.00 422.17 ? 356 HIS A CA    1 
ATOM   2264 C C     . HIS A 1 356 ? 113.572 119.223 109.284 1.00 422.17 ? 356 HIS A C     1 
ATOM   2265 O O     . HIS A 1 356 ? 113.918 118.037 109.124 1.00 422.17 ? 356 HIS A O     1 
ATOM   2266 C CB    . HIS A 1 356 ? 111.327 118.588 108.294 1.00 422.17 ? 356 HIS A CB    1 
ATOM   2267 C CG    . HIS A 1 356 ? 111.410 117.997 106.928 1.00 422.17 ? 356 HIS A CG    1 
ATOM   2268 N ND1   . HIS A 1 356 ? 110.745 118.541 105.847 1.00 422.17 ? 356 HIS A ND1   1 
ATOM   2269 C CD2   . HIS A 1 356 ? 112.092 116.931 106.457 1.00 422.17 ? 356 HIS A CD2   1 
ATOM   2270 C CE1   . HIS A 1 356 ? 111.002 117.825 104.771 1.00 422.17 ? 356 HIS A CE1   1 
ATOM   2271 N NE2   . HIS A 1 356 ? 111.826 116.832 105.119 1.00 422.17 ? 356 HIS A NE2   1 
ATOM   2272 N N     . ILE A 1 357 ? 114.194 120.085 110.100 1.00 376.03 ? 357 ILE A N     1 
ATOM   2273 C CA    . ILE A 1 357 ? 115.376 119.691 110.932 1.00 376.03 ? 357 ILE A CA    1 
ATOM   2274 C C     . ILE A 1 357 ? 115.346 120.493 112.242 1.00 376.03 ? 357 ILE A C     1 
ATOM   2275 O O     . ILE A 1 357 ? 114.796 121.609 112.223 1.00 376.03 ? 357 ILE A O     1 
ATOM   2276 C CB    . ILE A 1 357 ? 116.695 119.927 110.166 1.00 376.03 ? 357 ILE A CB    1 
ATOM   2277 C CG1   . ILE A 1 357 ? 116.616 119.468 108.707 1.00 376.03 ? 357 ILE A CG1   1 
ATOM   2278 C CG2   . ILE A 1 357 ? 117.867 119.283 110.892 1.00 376.03 ? 357 ILE A CG2   1 
ATOM   2279 C CD1   . ILE A 1 357 ? 117.923 119.570 107.957 1.00 376.03 ? 357 ILE A CD1   1 
ATOM   2280 N N     . ASN A 1 358 ? 115.924 119.964 113.331 1.00 546.17 ? 358 ASN A N     1 
ATOM   2281 C CA    . ASN A 1 358 ? 116.141 120.790 114.554 1.00 546.17 ? 358 ASN A CA    1 
ATOM   2282 C C     . ASN A 1 358 ? 117.501 121.486 114.452 1.00 546.17 ? 358 ASN A C     1 
ATOM   2283 O O     . ASN A 1 358 ? 118.278 121.128 113.546 1.00 546.17 ? 358 ASN A O     1 
ATOM   2284 C CB    . ASN A 1 358 ? 116.002 119.996 115.859 1.00 546.17 ? 358 ASN A CB    1 
ATOM   2285 C CG    . ASN A 1 358 ? 117.212 120.097 116.767 1.00 546.17 ? 358 ASN A CG    1 
ATOM   2286 O OD1   . ASN A 1 358 ? 118.292 119.609 116.438 1.00 546.17 ? 358 ASN A OD1   1 
ATOM   2287 N ND2   . ASN A 1 358 ? 117.049 120.744 117.909 1.00 546.17 ? 358 ASN A ND2   1 
ATOM   2288 N N     . THR A 1 359 ? 117.783 122.425 115.358 1.00 569.67 ? 359 THR A N     1 
ATOM   2289 C CA    . THR A 1 359 ? 119.040 123.206 115.240 1.00 569.67 ? 359 THR A CA    1 
ATOM   2290 C C     . THR A 1 359 ? 119.875 123.145 116.519 1.00 569.67 ? 359 THR A C     1 
ATOM   2291 O O     . THR A 1 359 ? 121.040 122.712 116.416 1.00 569.67 ? 359 THR A O     1 
ATOM   2292 C CB    . THR A 1 359 ? 118.733 124.665 114.887 1.00 569.67 ? 359 THR A CB    1 
ATOM   2293 O OG1   . THR A 1 359 ? 117.990 125.226 115.971 1.00 569.67 ? 359 THR A OG1   1 
ATOM   2294 C CG2   . THR A 1 359 ? 117.949 124.805 113.601 1.00 569.67 ? 359 THR A CG2   1 
ATOM   2295 N N     . LYS A 1 360 ? 119.331 123.572 117.668 1.00 546.28 ? 360 LYS A N     1 
ATOM   2296 C CA    . LYS A 1 360 ? 120.186 123.636 118.845 1.00 546.28 ? 360 LYS A CA    1 
ATOM   2297 C C     . LYS A 1 360 ? 120.969 122.351 119.078 1.00 546.28 ? 360 LYS A C     1 
ATOM   2298 O O     . LYS A 1 360 ? 121.938 122.356 119.844 1.00 546.28 ? 360 LYS A O     1 
ATOM   2299 C CB    . LYS A 1 360 ? 119.342 123.942 120.086 1.00 546.28 ? 360 LYS A CB    1 
ATOM   2300 C CG    . LYS A 1 360 ? 118.139 124.834 119.813 1.00 546.28 ? 360 LYS A CG    1 
ATOM   2301 C CD    . LYS A 1 360 ? 117.194 124.876 121.007 1.00 546.28 ? 360 LYS A CD    1 
ATOM   2302 C CE    . LYS A 1 360 ? 115.947 125.691 120.697 1.00 546.28 ? 360 LYS A CE    1 
ATOM   2303 N NZ    . LYS A 1 360 ? 114.972 125.681 121.823 1.00 546.28 ? 360 LYS A NZ    1 
ATOM   2304 N N     . THR A 1 361 ? 120.571 121.246 118.439 1.00 535.16 ? 361 THR A N     1 
ATOM   2305 C CA    . THR A 1 361 ? 121.252 119.968 118.600 1.00 535.16 ? 361 THR A CA    1 
ATOM   2306 C C     . THR A 1 361 ? 121.630 119.308 117.283 1.00 535.16 ? 361 THR A C     1 
ATOM   2307 O O     . THR A 1 361 ? 122.241 118.234 117.306 1.00 535.16 ? 361 THR A O     1 
ATOM   2308 C CB    . THR A 1 361 ? 120.378 118.990 119.400 1.00 535.16 ? 361 THR A CB    1 
ATOM   2309 O OG1   . THR A 1 361 ? 119.153 118.754 118.695 1.00 535.16 ? 361 THR A OG1   1 
ATOM   2310 C CG2   . THR A 1 361 ? 120.064 119.548 120.782 1.00 535.16 ? 361 THR A CG2   1 
ATOM   2311 N N     . ASN A 1 362 ? 121.284 119.917 116.148 1.00 497.58 ? 362 ASN A N     1 
ATOM   2312 C CA    . ASN A 1 362 ? 121.534 119.368 114.813 1.00 497.58 ? 362 ASN A CA    1 
ATOM   2313 C C     . ASN A 1 362 ? 120.942 117.969 114.661 1.00 497.58 ? 362 ASN A C     1 
ATOM   2314 O O     . ASN A 1 362 ? 121.438 117.145 113.888 1.00 497.58 ? 362 ASN A O     1 
ATOM   2315 C CB    . ASN A 1 362 ? 123.030 119.360 114.487 1.00 497.58 ? 362 ASN A CB    1 
ATOM   2316 C CG    . ASN A 1 362 ? 123.622 120.755 114.446 1.00 497.58 ? 362 ASN A CG    1 
ATOM   2317 O OD1   . ASN A 1 362 ? 122.906 121.741 114.273 1.00 497.58 ? 362 ASN A OD1   1 
ATOM   2318 N ND2   . ASN A 1 362 ? 124.936 120.844 114.610 1.00 497.58 ? 362 ASN A ND2   1 
ATOM   2319 N N     . LYS A 1 363 ? 119.879 117.710 115.411 1.00 401.87 ? 363 LYS A N     1 
ATOM   2320 C CA    . LYS A 1 363 ? 119.178 116.438 115.450 1.00 401.87 ? 363 LYS A CA    1 
ATOM   2321 C C     . LYS A 1 363 ? 117.809 116.625 114.819 1.00 401.87 ? 363 LYS A C     1 
ATOM   2322 O O     . LYS A 1 363 ? 117.200 117.690 114.929 1.00 401.87 ? 363 LYS A O     1 
ATOM   2323 C CB    . LYS A 1 363 ? 119.032 115.881 116.874 1.00 401.87 ? 363 LYS A CB    1 
ATOM   2324 C CG    . LYS A 1 363 ? 120.287 115.228 117.418 1.00 401.87 ? 363 LYS A CG    1 
ATOM   2325 C CD    . LYS A 1 363 ? 120.003 114.529 118.737 1.00 401.87 ? 363 LYS A CD    1 
ATOM   2326 C CE    . LYS A 1 363 ? 121.207 113.738 119.217 1.00 401.87 ? 363 LYS A CE    1 
ATOM   2327 N NZ    . LYS A 1 363 ? 120.912 112.996 120.474 1.00 401.87 ? 363 LYS A NZ    1 
ATOM   2328 N N     . ILE A 1 364 ? 117.320 115.596 114.144 1.00 297.12 ? 364 ILE A N     1 
ATOM   2329 C CA    . ILE A 1 364 ? 115.941 115.624 113.687 1.00 297.12 ? 364 ILE A CA    1 
ATOM   2330 C C     . ILE A 1 364 ? 115.127 114.748 114.625 1.00 297.12 ? 364 ILE A C     1 
ATOM   2331 O O     . ILE A 1 364 ? 115.498 113.603 114.910 1.00 297.12 ? 364 ILE A O     1 
ATOM   2332 C CB    . ILE A 1 364 ? 115.825 115.136 112.235 1.00 297.12 ? 364 ILE A CB    1 
ATOM   2333 C CG1   . ILE A 1 364 ? 116.541 116.100 111.287 1.00 297.12 ? 364 ILE A CG1   1 
ATOM   2334 C CG2   . ILE A 1 364 ? 114.369 114.979 111.845 1.00 297.12 ? 364 ILE A CG2   1 
ATOM   2335 C CD1   . ILE A 1 364 ? 116.613 115.604 109.861 1.00 297.12 ? 364 ILE A CD1   1 
ATOM   2336 N N     . HIS A 1 365 ? 114.014 115.291 115.102 1.00 319.01 ? 365 HIS A N     1 
ATOM   2337 C CA    . HIS A 1 365 ? 113.088 114.595 115.988 1.00 319.01 ? 365 HIS A CA    1 
ATOM   2338 C C     . HIS A 1 365 ? 111.753 114.447 115.273 1.00 319.01 ? 365 HIS A C     1 
ATOM   2339 O O     . HIS A 1 365 ? 110.869 115.297 115.406 1.00 319.01 ? 365 HIS A O     1 
ATOM   2340 C CB    . HIS A 1 365 ? 112.950 115.332 117.315 1.00 319.01 ? 365 HIS A CB    1 
ATOM   2341 C CG    . HIS A 1 365 ? 114.222 115.390 118.102 1.00 319.01 ? 365 HIS A CG    1 
ATOM   2342 N ND1   . HIS A 1 365 ? 114.544 114.456 119.064 1.00 319.01 ? 365 HIS A ND1   1 
ATOM   2343 C CD2   . HIS A 1 365 ? 115.259 116.261 118.062 1.00 319.01 ? 365 HIS A CD2   1 
ATOM   2344 C CE1   . HIS A 1 365 ? 115.721 114.753 119.586 1.00 319.01 ? 365 HIS A CE1   1 
ATOM   2345 N NE2   . HIS A 1 365 ? 116.176 115.842 118.996 1.00 319.01 ? 365 HIS A NE2   1 
ATOM   2346 N N     . THR A 1 366 ? 111.611 113.369 114.515 1.00 328.13 ? 366 THR A N     1 
ATOM   2347 C CA    . THR A 1 366 ? 110.392 113.129 113.765 1.00 328.13 ? 366 THR A CA    1 
ATOM   2348 C C     . THR A 1 366 ? 109.272 112.769 114.730 1.00 328.13 ? 366 THR A C     1 
ATOM   2349 O O     . THR A 1 366 ? 109.500 112.529 115.919 1.00 328.13 ? 366 THR A O     1 
ATOM   2350 C CB    . THR A 1 366 ? 110.583 112.010 112.746 1.00 328.13 ? 366 THR A CB    1 
ATOM   2351 O OG1   . THR A 1 366 ? 109.455 111.973 111.862 1.00 328.13 ? 366 THR A OG1   1 
ATOM   2352 C CG2   . THR A 1 366 ? 110.689 110.683 113.457 1.00 328.13 ? 366 THR A CG2   1 
ATOM   2353 N N     . THR A 1 367 ? 108.053 112.727 114.209 1.00 381.17 ? 367 THR A N     1 
ATOM   2354 C CA    . THR A 1 367 ? 106.891 112.358 115.004 1.00 381.17 ? 367 THR A CA    1 
ATOM   2355 C C     . THR A 1 367 ? 106.424 110.981 114.555 1.00 381.17 ? 367 THR A C     1 
ATOM   2356 O O     . THR A 1 367 ? 106.056 110.794 113.391 1.00 381.17 ? 367 THR A O     1 
ATOM   2357 C CB    . THR A 1 367 ? 105.770 113.386 114.853 1.00 381.17 ? 367 THR A CB    1 
ATOM   2358 O OG1   . THR A 1 367 ? 106.181 114.630 115.430 1.00 381.17 ? 367 THR A OG1   1 
ATOM   2359 C CG2   . THR A 1 367 ? 104.509 112.900 115.551 1.00 381.17 ? 367 THR A CG2   1 
ATOM   2360 N N     . PHE A 1 368 ? 106.455 110.025 115.479 1.00 368.17 ? 368 PHE A N     1 
ATOM   2361 C CA    . PHE A 1 368 ? 105.988 108.670 115.231 1.00 368.17 ? 368 PHE A CA    1 
ATOM   2362 C C     . PHE A 1 368 ? 104.551 108.494 115.696 1.00 368.17 ? 368 PHE A C     1 
ATOM   2363 O O     . PHE A 1 368 ? 104.222 108.768 116.853 1.00 368.17 ? 368 PHE A O     1 
ATOM   2364 C CB    . PHE A 1 368 ? 106.865 107.643 115.950 1.00 368.17 ? 368 PHE A CB    1 
ATOM   2365 C CG    . PHE A 1 368 ? 108.177 107.377 115.279 1.00 368.17 ? 368 PHE A CG    1 
ATOM   2366 C CD1   . PHE A 1 368 ? 108.247 106.538 114.182 1.00 368.17 ? 368 PHE A CD1   1 
ATOM   2367 C CD2   . PHE A 1 368 ? 109.343 107.947 115.760 1.00 368.17 ? 368 PHE A CD2   1 
ATOM   2368 C CE1   . PHE A 1 368 ? 109.454 106.281 113.565 1.00 368.17 ? 368 PHE A CE1   1 
ATOM   2369 C CE2   . PHE A 1 368 ? 110.556 107.689 115.150 1.00 368.17 ? 368 PHE A CE2   1 
ATOM   2370 C CZ    . PHE A 1 368 ? 110.611 106.857 114.049 1.00 368.17 ? 368 PHE A CZ    1 
ATOM   2371 N N     . ASN A 1 369 ? 103.707 108.035 114.781 1.00 357.80 ? 369 ASN A N     1 
ATOM   2372 C CA    . ASN A 1 369 ? 102.321 107.709 115.066 1.00 357.80 ? 369 ASN A CA    1 
ATOM   2373 C C     . ASN A 1 369 ? 102.274 106.211 115.339 1.00 357.80 ? 369 ASN A C     1 
ATOM   2374 O O     . ASN A 1 369 ? 102.731 105.401 114.516 1.00 357.80 ? 369 ASN A O     1 
ATOM   2375 C CB    . ASN A 1 369 ? 101.398 108.107 113.918 1.00 357.80 ? 369 ASN A CB    1 
ATOM   2376 C CG    . ASN A 1 369 ? 101.566 109.554 113.511 1.00 357.80 ? 369 ASN A CG    1 
ATOM   2377 O OD1   . ASN A 1 369 ? 101.842 109.856 112.351 1.00 357.80 ? 369 ASN A OD1   1 
ATOM   2378 N ND2   . ASN A 1 369 ? 101.403 110.460 114.468 1.00 357.80 ? 369 ASN A ND2   1 
ATOM   2379 N N     . GLN A 1 370 ? 101.729 105.860 116.503 1.00 395.00 ? 370 GLN A N     1 
ATOM   2380 C CA    . GLN A 1 370 ? 101.707 104.484 116.979 1.00 395.00 ? 370 GLN A CA    1 
ATOM   2381 C C     . GLN A 1 370 ? 100.568 103.696 116.352 1.00 395.00 ? 370 GLN A C     1 
ATOM   2382 O O     . GLN A 1 370 ? 100.746 102.527 115.988 1.00 395.00 ? 370 GLN A O     1 
ATOM   2383 C CB    . GLN A 1 370 ? 101.597 104.478 118.504 1.00 395.00 ? 370 GLN A CB    1 
ATOM   2384 C CG    . GLN A 1 370 ? 101.977 103.172 119.173 1.00 395.00 ? 370 GLN A CG    1 
ATOM   2385 C CD    . GLN A 1 370 ? 102.146 103.332 120.672 1.00 395.00 ? 370 GLN A CD    1 
ATOM   2386 O OE1   . GLN A 1 370 ? 101.973 104.425 121.211 1.00 395.00 ? 370 GLN A OE1   1 
ATOM   2387 N NE2   . GLN A 1 370 ? 102.496 102.246 121.351 1.00 395.00 ? 370 GLN A NE2   1 
ATOM   2388 N N     . LEU A 1 371 ? 99.401  104.319 116.212 1.00 384.06 ? 371 LEU A N     1 
ATOM   2389 C CA    . LEU A 1 371 ? 98.159  103.648 115.850 1.00 384.06 ? 371 LEU A CA    1 
ATOM   2390 C C     . LEU A 1 371 ? 97.387  104.454 114.816 1.00 384.06 ? 371 LEU A C     1 
ATOM   2391 O O     . LEU A 1 371 ? 96.212  104.773 115.017 1.00 384.06 ? 371 LEU A O     1 
ATOM   2392 C CB    . LEU A 1 371 ? 97.295  103.391 117.081 1.00 384.06 ? 371 LEU A CB    1 
ATOM   2393 C CG    . LEU A 1 371 ? 97.836  102.382 118.088 1.00 384.06 ? 371 LEU A CG    1 
ATOM   2394 C CD1   . LEU A 1 371 ? 96.984  102.393 119.334 1.00 384.06 ? 371 LEU A CD1   1 
ATOM   2395 C CD2   . LEU A 1 371 ? 97.872  100.994 117.471 1.00 384.06 ? 371 LEU A CD2   1 
ATOM   2396 N N     . LYS A 1 372 ? 98.047  104.813 113.715 1.00 411.60 ? 372 LYS A N     1 
ATOM   2397 C CA    . LYS A 1 372 ? 97.390  105.590 112.673 1.00 411.60 ? 372 LYS A CA    1 
ATOM   2398 C C     . LYS A 1 372 ? 97.471  104.865 111.335 1.00 411.60 ? 372 LYS A C     1 
ATOM   2399 O O     . LYS A 1 372 ? 96.953  105.352 110.323 1.00 411.60 ? 372 LYS A O     1 
ATOM   2400 C CB    . LYS A 1 372 ? 98.028  106.980 112.587 1.00 411.60 ? 372 LYS A CB    1 
ATOM   2401 C CG    . LYS A 1 372 ? 97.211  108.024 111.841 1.00 411.60 ? 372 LYS A CG    1 
ATOM   2402 C CD    . LYS A 1 372 ? 98.106  109.127 111.298 1.00 411.60 ? 372 LYS A CD    1 
ATOM   2403 C CE    . LYS A 1 372 ? 97.365  110.008 110.307 1.00 411.60 ? 372 LYS A CE    1 
ATOM   2404 N NZ    . LYS A 1 372 ? 98.264  111.032 109.709 1.00 411.60 ? 372 LYS A NZ    1 
ATOM   2405 N N     . THR A 1 373 ? 98.097  103.691 111.321 1.00 438.71 ? 373 THR A N     1 
ATOM   2406 C CA    . THR A 1 373 ? 98.078  102.808 110.167 1.00 438.71 ? 373 THR A CA    1 
ATOM   2407 C C     . THR A 1 373 ? 97.013  101.740 110.376 1.00 438.71 ? 373 THR A C     1 
ATOM   2408 O O     . THR A 1 373 ? 96.626  101.449 111.511 1.00 438.71 ? 373 THR A O     1 
ATOM   2409 C CB    . THR A 1 373 ? 99.443  102.151 109.954 1.00 438.71 ? 373 THR A CB    1 
ATOM   2410 O OG1   . THR A 1 373 ? 99.816  101.428 111.133 1.00 438.71 ? 373 THR A OG1   1 
ATOM   2411 C CG2   . THR A 1 373 ? 100.501 103.202 109.655 1.00 438.71 ? 373 THR A CG2   1 
ATOM   2412 N N     . PHE A 1 374 ? 96.560  101.135 109.277 1.00 408.03 ? 374 PHE A N     1 
ATOM   2413 C CA    . PHE A 1 374 ? 95.565  100.070 109.367 1.00 408.03 ? 374 PHE A CA    1 
ATOM   2414 C C     . PHE A 1 374 ? 96.105  98.849  110.102 1.00 408.03 ? 374 PHE A C     1 
ATOM   2415 O O     . PHE A 1 374 ? 95.383  98.264  110.917 1.00 408.03 ? 374 PHE A O     1 
ATOM   2416 C CB    . PHE A 1 374 ? 95.027  99.754  107.952 1.00 408.03 ? 374 PHE A CB    1 
ATOM   2417 C CG    . PHE A 1 374 ? 95.748  98.645  107.209 1.00 408.03 ? 374 PHE A CG    1 
ATOM   2418 C CD1   . PHE A 1 374 ? 95.639  97.310  107.590 1.00 408.03 ? 374 PHE A CD1   1 
ATOM   2419 C CD2   . PHE A 1 374 ? 96.535  98.951  106.110 1.00 408.03 ? 374 PHE A CD2   1 
ATOM   2420 C CE1   . PHE A 1 374 ? 96.301  96.317  106.894 1.00 408.03 ? 374 PHE A CE1   1 
ATOM   2421 C CE2   . PHE A 1 374 ? 97.199  97.959  105.412 1.00 408.03 ? 374 PHE A CE2   1 
ATOM   2422 C CZ    . PHE A 1 374 ? 97.079  96.643  105.805 1.00 408.03 ? 374 PHE A CZ    1 
ATOM   2423 N N     . SER A 1 375 ? 97.349  98.453  109.834 1.00 392.61 ? 375 SER A N     1 
ATOM   2424 C CA    . SER A 1 375 ? 97.926  97.246  110.408 1.00 392.61 ? 375 SER A CA    1 
ATOM   2425 C C     . SER A 1 375 ? 98.377  97.413  111.854 1.00 392.61 ? 375 SER A C     1 
ATOM   2426 O O     . SER A 1 375 ? 98.460  96.411  112.572 1.00 392.61 ? 375 SER A O     1 
ATOM   2427 C CB    . SER A 1 375 ? 99.110  96.783  109.556 1.00 392.61 ? 375 SER A CB    1 
ATOM   2428 O OG    . SER A 1 375 ? 100.145 97.750  109.553 1.00 392.61 ? 375 SER A OG    1 
ATOM   2429 N N     . GLY A 1 376 ? 98.668  98.633  112.302 1.00 419.33 ? 376 GLY A N     1 
ATOM   2430 C CA    . GLY A 1 376 ? 99.282  98.830  113.598 1.00 419.33 ? 376 GLY A CA    1 
ATOM   2431 C C     . GLY A 1 376 ? 100.781 99.033  113.575 1.00 419.33 ? 376 GLY A C     1 
ATOM   2432 O O     . GLY A 1 376 ? 101.373 99.273  114.636 1.00 419.33 ? 376 GLY A O     1 
ATOM   2433 N N     . ARG A 1 377 ? 101.408 98.941  112.408 1.00 357.28 ? 377 ARG A N     1 
ATOM   2434 C CA    . ARG A 1 377 ? 102.814 99.287  112.262 1.00 357.28 ? 377 ARG A CA    1 
ATOM   2435 C C     . ARG A 1 377 ? 103.042 100.751 112.617 1.00 357.28 ? 377 ARG A C     1 
ATOM   2436 O O     . ARG A 1 377 ? 102.132 101.582 112.551 1.00 357.28 ? 377 ARG A O     1 
ATOM   2437 C CB    . ARG A 1 377 ? 103.296 98.982  110.846 1.00 357.28 ? 377 ARG A CB    1 
ATOM   2438 C CG    . ARG A 1 377 ? 103.523 97.497  110.631 1.00 357.28 ? 377 ARG A CG    1 
ATOM   2439 C CD    . ARG A 1 377 ? 104.004 97.161  109.236 1.00 357.28 ? 377 ARG A CD    1 
ATOM   2440 N NE    . ARG A 1 377 ? 104.189 95.722  109.097 1.00 357.28 ? 377 ARG A NE    1 
ATOM   2441 C CZ    . ARG A 1 377 ? 104.507 95.106  107.967 1.00 357.28 ? 377 ARG A CZ    1 
ATOM   2442 N NH1   . ARG A 1 377 ? 104.608 93.780  107.958 1.00 357.28 ? 377 ARG A NH1   1 
ATOM   2443 N NH2   . ARG A 1 377 ? 104.741 95.782  106.853 1.00 357.28 ? 377 ARG A NH2   1 
ATOM   2444 N N     . PHE A 1 378 ? 104.277 101.063 112.998 1.00 319.76 ? 378 PHE A N     1 
ATOM   2445 C CA    . PHE A 1 378 ? 104.663 102.451 113.205 1.00 319.76 ? 378 PHE A CA    1 
ATOM   2446 C C     . PHE A 1 378 ? 104.527 103.239 111.913 1.00 319.76 ? 378 PHE A C     1 
ATOM   2447 O O     . PHE A 1 378 ? 104.703 102.706 110.815 1.00 319.76 ? 378 PHE A O     1 
ATOM   2448 C CB    . PHE A 1 378 ? 106.111 102.540 113.683 1.00 319.76 ? 378 PHE A CB    1 
ATOM   2449 C CG    . PHE A 1 378 ? 106.330 102.036 115.074 1.00 319.76 ? 378 PHE A CG    1 
ATOM   2450 C CD1   . PHE A 1 378 ? 105.774 102.691 116.158 1.00 319.76 ? 378 PHE A CD1   1 
ATOM   2451 C CD2   . PHE A 1 378 ? 107.109 100.914 115.299 1.00 319.76 ? 378 PHE A CD2   1 
ATOM   2452 C CE1   . PHE A 1 378 ? 105.984 102.232 117.444 1.00 319.76 ? 378 PHE A CE1   1 
ATOM   2453 C CE2   . PHE A 1 378 ? 107.322 100.450 116.579 1.00 319.76 ? 378 PHE A CE2   1 
ATOM   2454 C CZ    . PHE A 1 378 ? 106.762 101.110 117.654 1.00 319.76 ? 378 PHE A CZ    1 
ATOM   2455 N N     . SER A 1 379 ? 104.209 104.521 112.056 1.00 413.56 ? 379 SER A N     1 
ATOM   2456 C CA    . SER A 1 379 ? 104.378 105.483 110.979 1.00 413.56 ? 379 SER A CA    1 
ATOM   2457 C C     . SER A 1 379 ? 105.151 106.687 111.496 1.00 413.56 ? 379 SER A C     1 
ATOM   2458 O O     . SER A 1 379 ? 105.255 106.907 112.702 1.00 413.56 ? 379 SER A O     1 
ATOM   2459 C CB    . SER A 1 379 ? 103.026 105.914 110.402 1.00 413.56 ? 379 SER A CB    1 
ATOM   2460 O OG    . SER A 1 379 ? 102.250 106.593 111.370 1.00 413.56 ? 379 SER A OG    1 
ATOM   2461 N N     . SER A 1 380 ? 105.715 107.458 110.572 1.00 462.80 ? 380 SER A N     1 
ATOM   2462 C CA    . SER A 1 380 ? 106.510 108.621 110.931 1.00 462.80 ? 380 SER A CA    1 
ATOM   2463 C C     . SER A 1 380 ? 106.137 109.803 110.052 1.00 462.80 ? 380 SER A C     1 
ATOM   2464 O O     . SER A 1 380 ? 105.552 109.643 108.978 1.00 462.80 ? 380 SER A O     1 
ATOM   2465 C CB    . SER A 1 380 ? 108.014 108.335 110.802 1.00 462.80 ? 380 SER A CB    1 
ATOM   2466 O OG    . SER A 1 380 ? 108.326 107.820 109.520 1.00 462.80 ? 380 SER A OG    1 
ATOM   2467 N N     . GLU A 1 381 ? 106.469 110.998 110.534 1.00 405.54 ? 381 GLU A N     1 
ATOM   2468 C CA    . GLU A 1 381 ? 106.148 112.219 109.818 1.00 405.54 ? 381 GLU A CA    1 
ATOM   2469 C C     . GLU A 1 381 ? 107.091 113.326 110.262 1.00 405.54 ? 381 GLU A C     1 
ATOM   2470 O O     . GLU A 1 381 ? 107.623 113.314 111.378 1.00 405.54 ? 381 GLU A O     1 
ATOM   2471 C CB    . GLU A 1 381 ? 104.692 112.641 110.049 1.00 405.54 ? 381 GLU A CB    1 
ATOM   2472 C CG    . GLU A 1 381 ? 104.367 112.961 111.499 1.00 405.54 ? 381 GLU A CG    1 
ATOM   2473 C CD    . GLU A 1 381 ? 102.880 112.934 111.788 1.00 405.54 ? 381 GLU A CD    1 
ATOM   2474 O OE1   . GLU A 1 381 ? 102.096 112.667 110.853 1.00 405.54 ? 381 GLU A OE1   1 
ATOM   2475 O OE2   . GLU A 1 381 ? 102.494 113.181 112.950 1.00 405.54 ? 381 GLU A OE2   1 
ATOM   2476 N N     . LYS A 1 382 ? 107.280 114.290 109.362 1.00 339.42 ? 382 LYS A N     1 
ATOM   2477 C CA    . LYS A 1 382 ? 108.079 115.493 109.564 1.00 339.42 ? 382 LYS A CA    1 
ATOM   2478 C C     . LYS A 1 382 ? 109.494 115.182 110.044 1.00 339.42 ? 382 LYS A C     1 
ATOM   2479 O O     . LYS A 1 382 ? 109.885 115.631 111.128 1.00 339.42 ? 382 LYS A O     1 
ATOM   2480 C CB    . LYS A 1 382 ? 107.382 116.428 110.553 1.00 339.42 ? 382 LYS A CB    1 
ATOM   2481 C CG    . LYS A 1 382 ? 106.033 116.935 110.072 1.00 339.42 ? 382 LYS A CG    1 
ATOM   2482 C CD    . LYS A 1 382 ? 105.380 117.844 111.099 1.00 339.42 ? 382 LYS A CD    1 
ATOM   2483 C CE    . LYS A 1 382 ? 104.028 118.343 110.612 1.00 339.42 ? 382 LYS A CE    1 
ATOM   2484 N NZ    . LYS A 1 382 ? 103.395 119.277 111.583 1.00 339.42 ? 382 LYS A NZ    1 
ATOM   2485 N N     . LEU A 1 385 ? 110.445 108.797 108.108 1.00 422.89 ? 385 LEU A N     1 
ATOM   2486 C CA    . LEU A 1 385 ? 111.712 108.082 108.008 1.00 422.89 ? 385 LEU A CA    1 
ATOM   2487 C C     . LEU A 1 385 ? 111.629 106.823 107.151 1.00 422.89 ? 385 LEU A C     1 
ATOM   2488 O O     . LEU A 1 385 ? 112.632 106.440 106.540 1.00 422.89 ? 385 LEU A O     1 
ATOM   2489 C CB    . LEU A 1 385 ? 112.245 107.727 109.397 1.00 422.89 ? 385 LEU A CB    1 
ATOM   2490 C CG    . LEU A 1 385 ? 112.586 108.922 110.290 1.00 422.89 ? 385 LEU A CG    1 
ATOM   2491 C CD1   . LEU A 1 385 ? 112.802 108.470 111.720 1.00 422.89 ? 385 LEU A CD1   1 
ATOM   2492 C CD2   . LEU A 1 385 ? 113.812 109.647 109.760 1.00 422.89 ? 385 LEU A CD2   1 
ATOM   2493 N N     . GLN A 1 386 ? 110.464 106.174 107.092 1.00 456.79 ? 386 GLN A N     1 
ATOM   2494 C CA    . GLN A 1 386 ? 110.302 104.937 106.339 1.00 456.79 ? 386 GLN A CA    1 
ATOM   2495 C C     . GLN A 1 386 ? 110.149 105.152 104.841 1.00 456.79 ? 386 GLN A C     1 
ATOM   2496 O O     . GLN A 1 386 ? 110.319 104.198 104.075 1.00 456.79 ? 386 GLN A O     1 
ATOM   2497 C CB    . GLN A 1 386 ? 109.071 104.182 106.851 1.00 456.79 ? 386 GLN A CB    1 
ATOM   2498 C CG    . GLN A 1 386 ? 109.279 103.436 108.155 1.00 456.79 ? 386 GLN A CG    1 
ATOM   2499 C CD    . GLN A 1 386 ? 108.041 102.673 108.589 1.00 456.79 ? 386 GLN A CD    1 
ATOM   2500 O OE1   . GLN A 1 386 ? 107.083 102.535 107.832 1.00 456.79 ? 386 GLN A OE1   1 
ATOM   2501 N NE2   . GLN A 1 386 ? 108.061 102.172 109.830 1.00 456.79 ? 386 GLN A NE2   1 
ATOM   2502 N N     . GLN A 1 387 ? 109.835 106.368 104.405 1.00 350.33 ? 387 GLN A N     1 
ATOM   2503 C CA    . GLN A 1 387 ? 109.775 106.716 102.991 1.00 350.33 ? 387 GLN A CA    1 
ATOM   2504 C C     . GLN A 1 387 ? 111.123 107.212 102.488 1.00 350.33 ? 387 GLN A C     1 
ATOM   2505 O O     . GLN A 1 387 ? 111.269 107.555 101.312 1.00 350.33 ? 387 GLN A O     1 
ATOM   2506 C CB    . GLN A 1 387 ? 108.685 107.755 102.729 1.00 350.33 ? 387 GLN A CB    1 
ATOM   2507 C CG    . GLN A 1 387 ? 107.282 107.248 103.019 1.00 350.33 ? 387 GLN A CG    1 
ATOM   2508 C CD    . GLN A 1 387 ? 106.296 107.600 101.926 1.00 350.33 ? 387 GLN A CD    1 
ATOM   2509 O OE1   . GLN A 1 387 ? 105.741 106.718 101.267 1.00 350.33 ? 387 GLN A OE1   1 
ATOM   2510 N NE2   . GLN A 1 387 ? 106.075 108.892 101.722 1.00 350.33 ? 387 GLN A NE2   1 
ATOM   2511 N N     . ILE A 1 388 ? 112.118 107.256 103.364 1.00 287.63 ? 388 ILE A N     1 
ATOM   2512 C CA    . ILE A 1 388 ? 113.479 107.589 102.924 1.00 287.63 ? 388 ILE A CA    1 
ATOM   2513 C C     . ILE A 1 388 ? 114.066 106.435 102.118 1.00 287.63 ? 388 ILE A C     1 
ATOM   2514 O O     . ILE A 1 388 ? 113.967 105.266 102.539 1.00 287.63 ? 388 ILE A O     1 
ATOM   2515 C CB    . ILE A 1 388 ? 114.359 107.910 104.135 1.00 287.63 ? 388 ILE A CB    1 
ATOM   2516 C CG1   . ILE A 1 388 ? 113.943 109.246 104.756 1.00 287.63 ? 388 ILE A CG1   1 
ATOM   2517 C CG2   . ILE A 1 388 ? 115.830 107.932 103.747 1.00 287.63 ? 388 ILE A CG2   1 
ATOM   2518 C CD1   . ILE A 1 388 ? 114.053 110.415 103.810 1.00 287.63 ? 388 ILE A CD1   1 
ATOM   2519 N N     . PRO A 1 389 ? 114.661 106.715 100.959 1.00 227.28 ? 389 PRO A N     1 
ATOM   2520 C CA    . PRO A 1 389 ? 115.236 105.663 100.111 1.00 227.28 ? 389 PRO A CA    1 
ATOM   2521 C C     . PRO A 1 389 ? 116.248 104.802 100.854 1.00 227.28 ? 389 PRO A C     1 
ATOM   2522 O O     . PRO A 1 389 ? 116.962 105.268 101.745 1.00 227.28 ? 389 PRO A O     1 
ATOM   2523 C CB    . PRO A 1 389 ? 115.890 106.448 98.970  1.00 227.28 ? 389 PRO A CB    1 
ATOM   2524 C CG    . PRO A 1 389 ? 115.086 107.700 98.893  1.00 227.28 ? 389 PRO A CG    1 
ATOM   2525 C CD    . PRO A 1 389 ? 114.705 108.035 100.305 1.00 227.28 ? 389 PRO A CD    1 
ATOM   2526 N N     . ARG A 1 390 ? 116.304 103.528 100.471 1.00 314.21 ? 390 ARG A N     1 
ATOM   2527 C CA    . ARG A 1 390 ? 117.186 102.559 101.108 1.00 314.21 ? 390 ARG A CA    1 
ATOM   2528 C C     . ARG A 1 390 ? 118.589 102.565 100.519 1.00 314.21 ? 390 ARG A C     1 
ATOM   2529 O O     . ARG A 1 390 ? 119.492 101.964 101.111 1.00 314.21 ? 390 ARG A O     1 
ATOM   2530 C CB    . ARG A 1 390 ? 116.585 101.158 100.978 1.00 314.21 ? 390 ARG A CB    1 
ATOM   2531 C CG    . ARG A 1 390 ? 115.229 101.012 101.637 1.00 314.21 ? 390 ARG A CG    1 
ATOM   2532 C CD    . ARG A 1 390 ? 114.728 99.577  101.589 1.00 314.21 ? 390 ARG A CD    1 
ATOM   2533 N NE    . ARG A 1 390 ? 113.304 99.499  101.899 1.00 314.21 ? 390 ARG A NE    1 
ATOM   2534 C CZ    . ARG A 1 390 ? 112.332 99.906  101.091 1.00 314.21 ? 390 ARG A CZ    1 
ATOM   2535 N NH1   . ARG A 1 390 ? 111.068 99.780  101.484 1.00 314.21 ? 390 ARG A NH1   1 
ATOM   2536 N NH2   . ARG A 1 390 ? 112.593 100.447 99.910  1.00 314.21 ? 390 ARG A NH2   1 
ATOM   2537 N N     . GLN A 1 391 ? 118.783 103.206 99.368  1.00 249.54 ? 391 GLN A N     1 
ATOM   2538 C CA    . GLN A 1 391 ? 120.080 103.237 98.703  1.00 249.54 ? 391 GLN A CA    1 
ATOM   2539 C C     . GLN A 1 391 ? 121.160 103.765 99.643  1.00 249.54 ? 391 GLN A C     1 
ATOM   2540 O O     . GLN A 1 391 ? 120.951 104.753 100.353 1.00 249.54 ? 391 GLN A O     1 
ATOM   2541 C CB    . GLN A 1 391 ? 119.995 104.103 97.449  1.00 249.54 ? 391 GLN A CB    1 
ATOM   2542 C CG    . GLN A 1 391 ? 118.825 103.757 96.542  1.00 249.54 ? 391 GLN A CG    1 
ATOM   2543 C CD    . GLN A 1 391 ? 118.725 104.673 95.337  1.00 249.54 ? 391 GLN A CD    1 
ATOM   2544 O OE1   . GLN A 1 391 ? 119.667 105.395 95.012  1.00 249.54 ? 391 GLN A OE1   1 
ATOM   2545 N NE2   . GLN A 1 391 ? 117.577 104.650 94.672  1.00 249.54 ? 391 GLN A NE2   1 
ATOM   2546 N N     . LYS A 1 392 ? 122.315 103.091 99.648  1.00 354.03 ? 392 LYS A N     1 
ATOM   2547 C CA    . LYS A 1 392 ? 123.428 103.502 100.501 1.00 354.03 ? 392 LYS A CA    1 
ATOM   2548 C C     . LYS A 1 392 ? 123.887 104.928 100.207 1.00 354.03 ? 392 LYS A C     1 
ATOM   2549 O O     . LYS A 1 392 ? 124.400 105.617 101.100 1.00 354.03 ? 392 LYS A O     1 
ATOM   2550 C CB    . LYS A 1 392 ? 124.591 102.523 100.317 1.00 354.03 ? 392 LYS A CB    1 
ATOM   2551 C CG    . LYS A 1 392 ? 125.835 102.839 101.134 1.00 354.03 ? 392 LYS A CG    1 
ATOM   2552 C CD    . LYS A 1 392 ? 126.758 101.634 101.214 1.00 354.03 ? 392 LYS A CD    1 
ATOM   2553 C CE    . LYS A 1 392 ? 127.840 101.830 102.265 1.00 354.03 ? 392 LYS A CE    1 
ATOM   2554 N NZ    . LYS A 1 392 ? 128.656 100.600 102.455 1.00 354.03 ? 392 LYS A NZ    1 
ATOM   2555 N N     . ASN A 1 393 ? 123.620 105.420 98.991  1.00 286.48 ? 393 ASN A N     1 
ATOM   2556 C CA    . ASN A 1 393 ? 123.966 106.800 98.654  1.00 286.48 ? 393 ASN A CA    1 
ATOM   2557 C C     . ASN A 1 393 ? 123.234 107.778 99.557  1.00 286.48 ? 393 ASN A C     1 
ATOM   2558 O O     . ASN A 1 393 ? 123.722 108.888 99.802  1.00 286.48 ? 393 ASN A O     1 
ATOM   2559 C CB    . ASN A 1 393 ? 123.655 107.089 97.183  1.00 286.48 ? 393 ASN A CB    1 
ATOM   2560 C CG    . ASN A 1 393 ? 122.235 107.586 96.967  1.00 286.48 ? 393 ASN A CG    1 
ATOM   2561 O OD1   . ASN A 1 393 ? 121.316 106.798 96.749  1.00 286.48 ? 393 ASN A OD1   1 
ATOM   2562 N ND2   . ASN A 1 393 ? 122.056 108.903 97.013  1.00 286.48 ? 393 ASN A ND2   1 
ATOM   2563 N N     . ILE A 1 394 ? 122.064 107.383 100.047 1.00 315.28 ? 394 ILE A N     1 
ATOM   2564 C CA    . ILE A 1 394 ? 121.217 108.288 100.811 1.00 315.28 ? 394 ILE A CA    1 
ATOM   2565 C C     . ILE A 1 394 ? 121.321 107.958 102.294 1.00 315.28 ? 394 ILE A C     1 
ATOM   2566 O O     . ILE A 1 394 ? 121.388 108.851 103.146 1.00 315.28 ? 394 ILE A O     1 
ATOM   2567 C CB    . ILE A 1 394 ? 119.768 108.221 100.295 1.00 315.28 ? 394 ILE A CB    1 
ATOM   2568 C CG1   . ILE A 1 394 ? 119.607 109.171 99.108  1.00 315.28 ? 394 ILE A CG1   1 
ATOM   2569 C CG2   . ILE A 1 394 ? 118.776 108.550 101.401 1.00 315.28 ? 394 ILE A CG2   1 
ATOM   2570 C CD1   . ILE A 1 394 ? 118.307 109.036 98.375  1.00 315.28 ? 394 ILE A CD1   1 
ATOM   2571 N N     . ARG A 1 395 ? 121.347 106.666 102.621 1.00 336.13 ? 395 ARG A N     1 
ATOM   2572 C CA    . ARG A 1 395 ? 121.424 106.241 104.011 1.00 336.13 ? 395 ARG A CA    1 
ATOM   2573 C C     . ARG A 1 395 ? 122.810 106.439 104.621 1.00 336.13 ? 395 ARG A C     1 
ATOM   2574 O O     . ARG A 1 395 ? 122.935 106.379 105.849 1.00 336.13 ? 395 ARG A O     1 
ATOM   2575 C CB    . ARG A 1 395 ? 121.016 104.772 104.129 1.00 336.13 ? 395 ARG A CB    1 
ATOM   2576 C CG    . ARG A 1 395 ? 119.553 104.511 103.817 1.00 336.13 ? 395 ARG A CG    1 
ATOM   2577 C CD    . ARG A 1 395 ? 119.077 103.211 104.441 1.00 336.13 ? 395 ARG A CD    1 
ATOM   2578 N NE    . ARG A 1 395 ? 117.627 103.086 104.385 1.00 336.13 ? 395 ARG A NE    1 
ATOM   2579 C CZ    . ARG A 1 395 ? 116.942 102.065 104.882 1.00 336.13 ? 395 ARG A CZ    1 
ATOM   2580 N NH1   . ARG A 1 395 ? 115.615 102.068 104.791 1.00 336.13 ? 395 ARG A NH1   1 
ATOM   2581 N NH2   . ARG A 1 395 ? 117.548 101.050 105.475 1.00 336.13 ? 395 ARG A NH2   1 
ATOM   2582 N N     . GLU A 1 396 ? 123.850 106.676 103.814 1.00 382.08 ? 396 GLU A N     1 
ATOM   2583 C CA    . GLU A 1 396 ? 125.138 107.046 104.399 1.00 382.08 ? 396 GLU A CA    1 
ATOM   2584 C C     . GLU A 1 396 ? 125.118 108.383 105.137 1.00 382.08 ? 396 GLU A C     1 
ATOM   2585 O O     . GLU A 1 396 ? 126.053 108.658 105.896 1.00 382.08 ? 396 GLU A O     1 
ATOM   2586 C CB    . GLU A 1 396 ? 126.219 107.092 103.318 1.00 382.08 ? 396 GLU A CB    1 
ATOM   2587 C CG    . GLU A 1 396 ? 126.928 105.770 103.087 1.00 382.08 ? 396 GLU A CG    1 
ATOM   2588 C CD    . GLU A 1 396 ? 128.076 105.894 102.104 1.00 382.08 ? 396 GLU A CD    1 
ATOM   2589 O OE1   . GLU A 1 396 ? 128.361 107.027 101.662 1.00 382.08 ? 396 GLU A OE1   1 
ATOM   2590 O OE2   . GLU A 1 396 ? 128.696 104.863 101.775 1.00 382.08 ? 396 GLU A OE2   1 
ATOM   2591 N N     . ILE A 1 397 ? 124.095 109.216 104.939 1.00 433.98 ? 397 ILE A N     1 
ATOM   2592 C CA    . ILE A 1 397 ? 124.047 110.516 105.607 1.00 433.98 ? 397 ILE A CA    1 
ATOM   2593 C C     . ILE A 1 397 ? 123.754 110.405 107.099 1.00 433.98 ? 397 ILE A C     1 
ATOM   2594 O O     . ILE A 1 397 ? 124.015 111.359 107.843 1.00 433.98 ? 397 ILE A O     1 
ATOM   2595 C CB    . ILE A 1 397 ? 123.022 111.456 104.952 1.00 433.98 ? 397 ILE A CB    1 
ATOM   2596 C CG1   . ILE A 1 397 ? 121.595 111.046 105.319 1.00 433.98 ? 397 ILE A CG1   1 
ATOM   2597 C CG2   . ILE A 1 397 ? 123.218 111.492 103.441 1.00 433.98 ? 397 ILE A CG2   1 
ATOM   2598 C CD1   . ILE A 1 397 ? 120.546 112.054 104.909 1.00 433.98 ? 397 ILE A CD1   1 
ATOM   2599 N N     . PHE A 1 398 ? 123.217 109.277 107.562 1.00 441.03 ? 398 PHE A N     1 
ATOM   2600 C CA    . PHE A 1 398 ? 122.863 109.123 108.969 1.00 441.03 ? 398 PHE A CA    1 
ATOM   2601 C C     . PHE A 1 398 ? 123.983 108.429 109.735 1.00 441.03 ? 398 PHE A C     1 
ATOM   2602 O O     . PHE A 1 398 ? 124.368 107.302 109.405 1.00 441.03 ? 398 PHE A O     1 
ATOM   2603 C CB    . PHE A 1 398 ? 121.574 108.317 109.113 1.00 441.03 ? 398 PHE A CB    1 
ATOM   2604 C CG    . PHE A 1 398 ? 120.395 108.908 108.399 1.00 441.03 ? 398 PHE A CG    1 
ATOM   2605 C CD1   . PHE A 1 398 ? 119.619 109.882 109.005 1.00 441.03 ? 398 PHE A CD1   1 
ATOM   2606 C CD2   . PHE A 1 398 ? 120.042 108.468 107.135 1.00 441.03 ? 398 PHE A CD2   1 
ATOM   2607 C CE1   . PHE A 1 398 ? 118.524 110.420 108.356 1.00 441.03 ? 398 PHE A CE1   1 
ATOM   2608 C CE2   . PHE A 1 398 ? 118.948 109.002 106.480 1.00 441.03 ? 398 PHE A CE2   1 
ATOM   2609 C CZ    . PHE A 1 398 ? 118.190 109.979 107.091 1.00 441.03 ? 398 PHE A CZ    1 
ATOM   2610 N N     . ILE A 1 399 ? 124.501 109.104 110.757 1.00 454.98 ? 399 ILE A N     1 
ATOM   2611 C CA    . ILE A 1 399 ? 125.692 108.656 111.477 1.00 454.98 ? 399 ILE A CA    1 
ATOM   2612 C C     . ILE A 1 399 ? 125.411 108.723 112.969 1.00 454.98 ? 399 ILE A C     1 
ATOM   2613 O O     . ILE A 1 399 ? 124.488 109.420 113.414 1.00 454.98 ? 399 ILE A O     1 
ATOM   2614 C CB    . ILE A 1 399 ? 126.927 109.511 111.128 1.00 454.98 ? 399 ILE A CB    1 
ATOM   2615 C CG1   . ILE A 1 399 ? 126.628 110.995 111.354 1.00 454.98 ? 399 ILE A CG1   1 
ATOM   2616 C CG2   . ILE A 1 399 ? 127.366 109.260 109.694 1.00 454.98 ? 399 ILE A CG2   1 
ATOM   2617 C CD1   . ILE A 1 399 ? 127.859 111.875 111.350 1.00 454.98 ? 399 ILE A CD1   1 
ATOM   2618 N N     . PRO A 1 400 ? 126.195 108.009 113.774 1.00 476.85 ? 400 PRO A N     1 
ATOM   2619 C CA    . PRO A 1 400 ? 126.076 108.135 115.229 1.00 476.85 ? 400 PRO A CA    1 
ATOM   2620 C C     . PRO A 1 400 ? 126.828 109.351 115.753 1.00 476.85 ? 400 PRO A C     1 
ATOM   2621 O O     . PRO A 1 400 ? 127.610 109.993 115.049 1.00 476.85 ? 400 PRO A O     1 
ATOM   2622 C CB    . PRO A 1 400 ? 126.697 106.835 115.747 1.00 476.85 ? 400 PRO A CB    1 
ATOM   2623 C CG    . PRO A 1 400 ? 127.676 106.454 114.708 1.00 476.85 ? 400 PRO A CG    1 
ATOM   2624 C CD    . PRO A 1 400 ? 127.120 106.926 113.393 1.00 476.85 ? 400 PRO A CD    1 
ATOM   2625 N N     . ASN A 1 401 ? 126.572 109.660 117.020 1.00 460.45 ? 401 ASN A N     1 
ATOM   2626 C CA    . ASN A 1 401 ? 127.287 110.731 117.691 1.00 460.45 ? 401 ASN A CA    1 
ATOM   2627 C C     . ASN A 1 401 ? 128.747 110.328 117.892 1.00 460.45 ? 401 ASN A C     1 
ATOM   2628 O O     . ASN A 1 401 ? 129.137 109.174 117.692 1.00 460.45 ? 401 ASN A O     1 
ATOM   2629 C CB    . ASN A 1 401 ? 126.628 111.058 119.030 1.00 460.45 ? 401 ASN A CB    1 
ATOM   2630 C CG    . ASN A 1 401 ? 125.247 111.662 118.867 1.00 460.45 ? 401 ASN A CG    1 
ATOM   2631 O OD1   . ASN A 1 401 ? 124.976 112.369 117.897 1.00 460.45 ? 401 ASN A OD1   1 
ATOM   2632 N ND2   . ASN A 1 401 ? 124.362 111.382 119.818 1.00 460.45 ? 401 ASN A ND2   1 
ATOM   2633 N N     . ASP A 1 402 ? 129.565 111.301 118.289 1.00 514.79 ? 402 ASP A N     1 
ATOM   2634 C CA    . ASP A 1 402 ? 130.977 111.025 118.514 1.00 514.79 ? 402 ASP A CA    1 
ATOM   2635 C C     . ASP A 1 402 ? 131.143 110.031 119.655 1.00 514.79 ? 402 ASP A C     1 
ATOM   2636 O O     . ASP A 1 402 ? 130.408 110.079 120.647 1.00 514.79 ? 402 ASP A O     1 
ATOM   2637 C CB    . ASP A 1 402 ? 131.727 112.322 118.822 1.00 514.79 ? 402 ASP A CB    1 
ATOM   2638 C CG    . ASP A 1 402 ? 131.663 113.315 117.681 1.00 514.79 ? 402 ASP A CG    1 
ATOM   2639 O OD1   . ASP A 1 402 ? 131.690 112.880 116.510 1.00 514.79 ? 402 ASP A OD1   1 
ATOM   2640 O OD2   . ASP A 1 402 ? 131.585 114.532 117.953 1.00 514.79 ? 402 ASP A OD2   1 
ATOM   2641 N N     . ASN A 1 403 ? 132.095 109.113 119.494 1.00 467.04 ? 403 ASN A N     1 
ATOM   2642 C CA    . ASN A 1 403 ? 132.446 108.036 120.417 1.00 467.04 ? 403 ASN A CA    1 
ATOM   2643 C C     . ASN A 1 403 ? 131.375 106.950 120.421 1.00 467.04 ? 403 ASN A C     1 
ATOM   2644 O O     . ASN A 1 403 ? 131.444 106.039 121.256 1.00 467.04 ? 403 ASN A O     1 
ATOM   2645 C CB    . ASN A 1 403 ? 132.686 108.518 121.858 1.00 467.04 ? 403 ASN A CB    1 
ATOM   2646 C CG    . ASN A 1 403 ? 133.788 109.552 121.950 1.00 467.04 ? 403 ASN A CG    1 
ATOM   2647 O OD1   . ASN A 1 403 ? 134.781 109.487 121.224 1.00 467.04 ? 403 ASN A OD1   1 
ATOM   2648 N ND2   . ASN A 1 403 ? 133.624 110.516 122.848 1.00 467.04 ? 403 ASN A ND2   1 
ATOM   2649 N N     . ASN A 1 404 ? 130.397 107.009 119.523 1.00 413.53 ? 404 ASN A N     1 
ATOM   2650 C CA    . ASN A 1 404 ? 129.332 106.023 119.449 1.00 413.53 ? 404 ASN A CA    1 
ATOM   2651 C C     . ASN A 1 404 ? 129.289 105.385 118.065 1.00 413.53 ? 404 ASN A C     1 
ATOM   2652 O O     . ASN A 1 404 ? 129.901 105.862 117.106 1.00 413.53 ? 404 ASN A O     1 
ATOM   2653 C CB    . ASN A 1 404 ? 127.977 106.659 119.780 1.00 413.53 ? 404 ASN A CB    1 
ATOM   2654 C CG    . ASN A 1 404 ? 127.889 107.140 121.215 1.00 413.53 ? 404 ASN A CG    1 
ATOM   2655 O OD1   . ASN A 1 404 ? 128.822 106.973 121.999 1.00 413.53 ? 404 ASN A OD1   1 
ATOM   2656 N ND2   . ASN A 1 404 ? 126.758 107.742 121.565 1.00 413.53 ? 404 ASN A ND2   1 
ATOM   2657 N N     . ILE A 1 405 ? 128.537 104.287 117.975 1.00 378.23 ? 405 ILE A N     1 
ATOM   2658 C CA    . ILE A 1 405 ? 128.374 103.523 116.745 1.00 378.23 ? 405 ILE A CA    1 
ATOM   2659 C C     . ILE A 1 405 ? 126.978 102.917 116.722 1.00 378.23 ? 405 ILE A C     1 
ATOM   2660 O O     . ILE A 1 405 ? 126.373 102.643 117.764 1.00 378.23 ? 405 ILE A O     1 
ATOM   2661 C CB    . ILE A 1 405 ? 129.434 102.409 116.589 1.00 378.23 ? 405 ILE A CB    1 
ATOM   2662 C CG1   . ILE A 1 405 ? 129.585 101.627 117.894 1.00 378.23 ? 405 ILE A CG1   1 
ATOM   2663 C CG2   . ILE A 1 405 ? 130.770 102.981 116.129 1.00 378.23 ? 405 ILE A CG2   1 
ATOM   2664 C CD1   . ILE A 1 405 ? 130.293 100.313 117.718 1.00 378.23 ? 405 ILE A CD1   1 
ATOM   2665 N N     . PHE A 1 406 ? 126.457 102.752 115.506 1.00 400.67 ? 406 PHE A N     1 
ATOM   2666 C CA    . PHE A 1 406 ? 125.151 102.154 115.293 1.00 400.67 ? 406 PHE A CA    1 
ATOM   2667 C C     . PHE A 1 406 ? 125.268 100.637 115.357 1.00 400.67 ? 406 PHE A C     1 
ATOM   2668 O O     . PHE A 1 406 ? 126.258 100.054 114.902 1.00 400.67 ? 406 PHE A O     1 
ATOM   2669 C CB    . PHE A 1 406 ? 124.572 102.583 113.944 1.00 400.67 ? 406 PHE A CB    1 
ATOM   2670 C CG    . PHE A 1 406 ? 124.008 103.975 113.944 1.00 400.67 ? 406 PHE A CG    1 
ATOM   2671 C CD1   . PHE A 1 406 ? 123.576 104.563 115.120 1.00 400.67 ? 406 PHE A CD1   1 
ATOM   2672 C CD2   . PHE A 1 406 ? 123.910 104.695 112.765 1.00 400.67 ? 406 PHE A CD2   1 
ATOM   2673 C CE1   . PHE A 1 406 ? 123.057 105.843 115.123 1.00 400.67 ? 406 PHE A CE1   1 
ATOM   2674 C CE2   . PHE A 1 406 ? 123.393 105.976 112.760 1.00 400.67 ? 406 PHE A CE2   1 
ATOM   2675 C CZ    . PHE A 1 406 ? 122.965 106.552 113.940 1.00 400.67 ? 406 PHE A CZ    1 
ATOM   2676 N N     . ILE A 1 407 ? 124.228 100.007 115.890 1.00 379.17 ? 407 ILE A N     1 
ATOM   2677 C CA    . ILE A 1 407 ? 124.023 98.568  115.808 1.00 379.17 ? 407 ILE A CA    1 
ATOM   2678 C C     . ILE A 1 407 ? 122.663 98.358  115.163 1.00 379.17 ? 407 ILE A C     1 
ATOM   2679 O O     . ILE A 1 407 ? 121.644 98.844  115.675 1.00 379.17 ? 407 ILE A O     1 
ATOM   2680 C CB    . ILE A 1 407 ? 124.067 97.913  117.198 1.00 379.17 ? 407 ILE A CB    1 
ATOM   2681 C CG1   . ILE A 1 407 ? 125.392 98.203  117.905 1.00 379.17 ? 407 ILE A CG1   1 
ATOM   2682 C CG2   . ILE A 1 407 ? 123.868 96.414  117.080 1.00 379.17 ? 407 ILE A CG2   1 
ATOM   2683 C CD1   . ILE A 1 407 ? 126.604 97.836  117.124 1.00 379.17 ? 407 ILE A CD1   1 
ATOM   2684 N N     . ILE A 1 408 ? 122.641 97.652  114.033 1.00 362.80 ? 408 ILE A N     1 
ATOM   2685 C CA    . ILE A 1 408 ? 121.440 97.517  113.218 1.00 362.80 ? 408 ILE A CA    1 
ATOM   2686 C C     . ILE A 1 408 ? 121.059 96.045  113.155 1.00 362.80 ? 408 ILE A C     1 
ATOM   2687 O O     . ILE A 1 408 ? 121.907 95.189  112.872 1.00 362.80 ? 408 ILE A O     1 
ATOM   2688 C CB    . ILE A 1 408 ? 121.656 98.090  111.807 1.00 362.80 ? 408 ILE A CB    1 
ATOM   2689 C CG1   . ILE A 1 408 ? 122.196 99.519  111.892 1.00 362.80 ? 408 ILE A CG1   1 
ATOM   2690 C CG2   . ILE A 1 408 ? 120.368 98.051  111.014 1.00 362.80 ? 408 ILE A CG2   1 
ATOM   2691 C CD1   . ILE A 1 408 ? 122.521 100.132 110.547 1.00 362.80 ? 408 ILE A CD1   1 
ATOM   2692 N N     . ALA A 1 409 ? 119.784 95.751  113.403 1.00 383.59 ? 409 ALA A N     1 
ATOM   2693 C CA    . ALA A 1 409 ? 119.281 94.386  113.437 1.00 383.59 ? 409 ALA A CA    1 
ATOM   2694 C C     . ALA A 1 409 ? 117.990 94.294  112.644 1.00 383.59 ? 409 ALA A C     1 
ATOM   2695 O O     . ALA A 1 409 ? 117.195 95.235  112.628 1.00 383.59 ? 409 ALA A O     1 
ATOM   2696 C CB    . ALA A 1 409 ? 119.041 93.902  114.865 1.00 383.59 ? 409 ALA A CB    1 
ATOM   2697 N N     . ASP A 1 410 ? 117.791 93.155  111.990 1.00 393.75 ? 410 ASP A N     1 
ATOM   2698 C CA    . ASP A 1 410 ? 116.612 92.902  111.178 1.00 393.75 ? 410 ASP A CA    1 
ATOM   2699 C C     . ASP A 1 410 ? 116.136 91.479  111.425 1.00 393.75 ? 410 ASP A C     1 
ATOM   2700 O O     . ASP A 1 410 ? 116.942 90.585  111.708 1.00 393.75 ? 410 ASP A O     1 
ATOM   2701 C CB    . ASP A 1 410 ? 116.911 93.111  109.688 1.00 393.75 ? 410 ASP A CB    1 
ATOM   2702 C CG    . ASP A 1 410 ? 115.671 93.004  108.824 1.00 393.75 ? 410 ASP A CG    1 
ATOM   2703 O OD1   . ASP A 1 410 ? 114.553 93.031  109.382 1.00 393.75 ? 410 ASP A OD1   1 
ATOM   2704 O OD2   . ASP A 1 410 ? 115.815 92.892  107.588 1.00 393.75 ? 410 ASP A OD2   1 
ATOM   2705 N N     . PHE A 1 411 ? 114.827 91.278  111.295 1.00 387.40 ? 411 PHE A N     1 
ATOM   2706 C CA    . PHE A 1 411 ? 114.277 89.940  111.138 1.00 387.40 ? 411 PHE A CA    1 
ATOM   2707 C C     . PHE A 1 411 ? 114.390 89.475  109.692 1.00 387.40 ? 411 PHE A C     1 
ATOM   2708 O O     . PHE A 1 411 ? 114.193 90.252  108.753 1.00 387.40 ? 411 PHE A O     1 
ATOM   2709 C CB    . PHE A 1 411 ? 112.806 89.911  111.555 1.00 387.40 ? 411 PHE A CB    1 
ATOM   2710 C CG    . PHE A 1 411 ? 112.571 90.192  113.011 1.00 387.40 ? 411 PHE A CG    1 
ATOM   2711 C CD1   . PHE A 1 411 ? 112.932 89.270  113.977 1.00 387.40 ? 411 PHE A CD1   1 
ATOM   2712 C CD2   . PHE A 1 411 ? 111.957 91.368  113.411 1.00 387.40 ? 411 PHE A CD2   1 
ATOM   2713 C CE1   . PHE A 1 411 ? 112.705 89.525  115.318 1.00 387.40 ? 411 PHE A CE1   1 
ATOM   2714 C CE2   . PHE A 1 411 ? 111.727 91.630  114.746 1.00 387.40 ? 411 PHE A CE2   1 
ATOM   2715 C CZ    . PHE A 1 411 ? 112.100 90.706  115.702 1.00 387.40 ? 411 PHE A CZ    1 
ATOM   2716 N N     . LYS A 1 412 ? 114.718 88.199  109.518 1.00 337.89 ? 412 LYS A N     1 
ATOM   2717 C CA    . LYS A 1 412 ? 114.761 87.600  108.191 1.00 337.89 ? 412 LYS A CA    1 
ATOM   2718 C C     . LYS A 1 412 ? 113.398 87.009  107.851 1.00 337.89 ? 412 LYS A C     1 
ATOM   2719 O O     . LYS A 1 412 ? 113.046 85.927  108.337 1.00 337.89 ? 412 LYS A O     1 
ATOM   2720 C CB    . LYS A 1 412 ? 115.851 86.532  108.122 1.00 337.89 ? 412 LYS A CB    1 
ATOM   2721 C CG    . LYS A 1 412 ? 117.247 87.061  108.409 1.00 337.89 ? 412 LYS A CG    1 
ATOM   2722 C CD    . LYS A 1 412 ? 118.300 85.984  108.211 1.00 337.89 ? 412 LYS A CD    1 
ATOM   2723 C CE    . LYS A 1 412 ? 119.669 86.456  108.671 1.00 337.89 ? 412 LYS A CE    1 
ATOM   2724 N NZ    . LYS A 1 412 ? 120.700 85.391  108.538 1.00 337.89 ? 412 LYS A NZ    1 
ATOM   2725 N N     . GLN A 1 413 ? 112.633 87.726  107.028 1.00 387.79 ? 413 GLN A N     1 
ATOM   2726 C CA    . GLN A 1 413 ? 111.342 87.260  106.520 1.00 387.79 ? 413 GLN A CA    1 
ATOM   2727 C C     . GLN A 1 413 ? 110.349 86.997  107.651 1.00 387.79 ? 413 GLN A C     1 
ATOM   2728 O O     . GLN A 1 413 ? 109.800 85.901  107.787 1.00 387.79 ? 413 GLN A O     1 
ATOM   2729 C CB    . GLN A 1 413 ? 111.520 86.010  105.654 1.00 387.79 ? 413 GLN A CB    1 
ATOM   2730 C CG    . GLN A 1 413 ? 112.123 86.287  104.288 1.00 387.79 ? 413 GLN A CG    1 
ATOM   2731 C CD    . GLN A 1 413 ? 112.312 85.025  103.469 1.00 387.79 ? 413 GLN A CD    1 
ATOM   2732 O OE1   . GLN A 1 413 ? 111.841 83.950  103.845 1.00 387.79 ? 413 GLN A OE1   1 
ATOM   2733 N NE2   . GLN A 1 413 ? 113.003 85.148  102.342 1.00 387.79 ? 413 GLN A NE2   1 
ATOM   2734 N N     . ILE A 1 414 ? 110.121 88.019  108.479 1.00 340.37 ? 414 ILE A N     1 
ATOM   2735 C CA    . ILE A 1 414 ? 109.259 87.852  109.648 1.00 340.37 ? 414 ILE A CA    1 
ATOM   2736 C C     . ILE A 1 414 ? 107.811 87.629  109.222 1.00 340.37 ? 414 ILE A C     1 
ATOM   2737 O O     . ILE A 1 414 ? 107.103 86.793  109.797 1.00 340.37 ? 414 ILE A O     1 
ATOM   2738 C CB    . ILE A 1 414 ? 109.406 89.057  110.600 1.00 340.37 ? 414 ILE A CB    1 
ATOM   2739 C CG1   . ILE A 1 414 ? 108.770 88.753  111.958 1.00 340.37 ? 414 ILE A CG1   1 
ATOM   2740 C CG2   . ILE A 1 414 ? 108.824 90.328  109.998 1.00 340.37 ? 414 ILE A CG2   1 
ATOM   2741 C CD1   . ILE A 1 414 ? 109.525 87.732  112.767 1.00 340.37 ? 414 ILE A CD1   1 
ATOM   2742 N N     . GLU A 1 415 ? 107.358 88.360  108.200 1.00 342.73 ? 415 GLU A N     1 
ATOM   2743 C CA    . GLU A 1 415 ? 105.983 88.246  107.723 1.00 342.73 ? 415 GLU A CA    1 
ATOM   2744 C C     . GLU A 1 415 ? 105.643 86.827  107.283 1.00 342.73 ? 415 GLU A C     1 
ATOM   2745 O O     . GLU A 1 415 ? 104.594 86.289  107.658 1.00 342.73 ? 415 GLU A O     1 
ATOM   2746 C CB    . GLU A 1 415 ? 105.751 89.224  106.574 1.00 342.73 ? 415 GLU A CB    1 
ATOM   2747 C CG    . GLU A 1 415 ? 105.773 90.684  106.981 1.00 342.73 ? 415 GLU A CG    1 
ATOM   2748 C CD    . GLU A 1 415 ? 105.401 91.605  105.839 1.00 342.73 ? 415 GLU A CD    1 
ATOM   2749 O OE1   . GLU A 1 415 ? 105.029 91.094  104.760 1.00 342.73 ? 415 GLU A OE1   1 
ATOM   2750 O OE2   . GLU A 1 415 ? 105.481 92.838  106.014 1.00 342.73 ? 415 GLU A OE2   1 
ATOM   2751 N N     . LEU A 1 416 ? 106.510 86.213  106.479 1.00 407.37 ? 416 LEU A N     1 
ATOM   2752 C CA    . LEU A 1 416 ? 106.217 84.881  105.964 1.00 407.37 ? 416 LEU A CA    1 
ATOM   2753 C C     . LEU A 1 416 ? 106.239 83.832  107.070 1.00 407.37 ? 416 LEU A C     1 
ATOM   2754 O O     . LEU A 1 416 ? 105.433 82.893  107.062 1.00 407.37 ? 416 LEU A O     1 
ATOM   2755 C CB    . LEU A 1 416 ? 107.212 84.534  104.860 1.00 407.37 ? 416 LEU A CB    1 
ATOM   2756 C CG    . LEU A 1 416 ? 107.209 85.469  103.649 1.00 407.37 ? 416 LEU A CG    1 
ATOM   2757 C CD1   . LEU A 1 416 ? 108.305 85.078  102.671 1.00 407.37 ? 416 LEU A CD1   1 
ATOM   2758 C CD2   . LEU A 1 416 ? 105.849 85.479  102.969 1.00 407.37 ? 416 LEU A CD2   1 
ATOM   2759 N N     . LYS A 1 417 ? 107.141 83.979  108.044 1.00 373.98 ? 417 LYS A N     1 
ATOM   2760 C CA    . LYS A 1 417 ? 107.145 83.053  109.172 1.00 373.98 ? 417 LYS A CA    1 
ATOM   2761 C C     . LYS A 1 417 ? 105.872 83.201  109.996 1.00 373.98 ? 417 LYS A C     1 
ATOM   2762 O O     . LYS A 1 417 ? 105.302 82.205  110.464 1.00 373.98 ? 417 LYS A O     1 
ATOM   2763 C CB    . LYS A 1 417 ? 108.379 83.300  110.039 1.00 373.98 ? 417 LYS A CB    1 
ATOM   2764 C CG    . LYS A 1 417 ? 109.689 82.922  109.374 1.00 373.98 ? 417 LYS A CG    1 
ATOM   2765 C CD    . LYS A 1 417 ? 110.876 83.354  110.218 1.00 373.98 ? 417 LYS A CD    1 
ATOM   2766 C CE    . LYS A 1 417 ? 112.189 82.950  109.569 1.00 373.98 ? 417 LYS A CE    1 
ATOM   2767 N NZ    . LYS A 1 417 ? 113.361 83.428  110.352 1.00 373.98 ? 417 LYS A NZ    1 
ATOM   2768 N N     . ILE A 1 418 ? 105.416 84.442  110.179 1.00 449.79 ? 418 ILE A N     1 
ATOM   2769 C CA    . ILE A 1 418 ? 104.154 84.677  110.870 1.00 449.79 ? 418 ILE A CA    1 
ATOM   2770 C C     . ILE A 1 418 ? 103.007 84.009  110.125 1.00 449.79 ? 418 ILE A C     1 
ATOM   2771 O O     . ILE A 1 418 ? 102.123 83.395  110.735 1.00 449.79 ? 418 ILE A O     1 
ATOM   2772 C CB    . ILE A 1 418 ? 103.918 86.190  111.036 1.00 449.79 ? 418 ILE A CB    1 
ATOM   2773 C CG1   . ILE A 1 418 ? 104.953 86.797  111.985 1.00 449.79 ? 418 ILE A CG1   1 
ATOM   2774 C CG2   . ILE A 1 418 ? 102.511 86.466  111.507 1.00 449.79 ? 418 ILE A CG2   1 
ATOM   2775 C CD1   . ILE A 1 418 ? 105.030 88.305  111.915 1.00 449.79 ? 418 ILE A CD1   1 
ATOM   2776 N N     . ALA A 1 419 ? 102.996 84.131  108.794 1.00 442.60 ? 419 ALA A N     1 
ATOM   2777 C CA    . ALA A 1 419 ? 101.962 83.476  107.999 1.00 442.60 ? 419 ALA A CA    1 
ATOM   2778 C C     . ALA A 1 419 ? 102.002 81.963  108.183 1.00 442.60 ? 419 ALA A C     1 
ATOM   2779 O O     . ALA A 1 419 ? 100.956 81.314  108.318 1.00 442.60 ? 419 ALA A O     1 
ATOM   2780 C CB    . ALA A 1 419 ? 102.123 83.842  106.524 1.00 442.60 ? 419 ALA A CB    1 
ATOM   2781 N N     . ALA A 1 420 ? 103.209 81.393  108.212 1.00 406.22 ? 420 ALA A N     1 
ATOM   2782 C CA    . ALA A 1 420 ? 103.351 79.951  108.384 1.00 406.22 ? 420 ALA A CA    1 
ATOM   2783 C C     . ALA A 1 420 ? 102.800 79.505  109.731 1.00 406.22 ? 420 ALA A C     1 
ATOM   2784 O O     . ALA A 1 420 ? 102.131 78.470  109.828 1.00 406.22 ? 420 ALA A O     1 
ATOM   2785 C CB    . ALA A 1 420 ? 104.816 79.543  108.238 1.00 406.22 ? 420 ALA A CB    1 
ATOM   2786 N N     . GLU A 1 421 ? 103.073 80.276  110.785 1.00 446.72 ? 421 GLU A N     1 
ATOM   2787 C CA    . GLU A 1 421 ? 102.573 79.915  112.109 1.00 446.72 ? 421 GLU A CA    1 
ATOM   2788 C C     . GLU A 1 421 ? 101.055 80.054  112.177 1.00 446.72 ? 421 GLU A C     1 
ATOM   2789 O O     . GLU A 1 421 ? 100.363 79.178  112.708 1.00 446.72 ? 421 GLU A O     1 
ATOM   2790 C CB    . GLU A 1 421 ? 103.252 80.761  113.187 1.00 446.72 ? 421 GLU A CB    1 
ATOM   2791 C CG    . GLU A 1 421 ? 102.631 80.604  114.569 1.00 446.72 ? 421 GLU A CG    1 
ATOM   2792 C CD    . GLU A 1 421 ? 103.635 80.183  115.623 1.00 446.72 ? 421 GLU A CD    1 
ATOM   2793 O OE1   . GLU A 1 421 ? 104.826 80.017  115.281 1.00 446.72 ? 421 GLU A OE1   1 
ATOM   2794 O OE2   . GLU A 1 421 ? 103.238 80.021  116.797 1.00 446.72 ? 421 GLU A OE2   1 
ATOM   2795 N N     . ASP A 1 425 ? 100.440 75.893  107.199 1.00 305.25 ? 425 ASP A N     1 
ATOM   2796 C CA    . ASP A 1 425 ? 100.699 75.117  105.995 1.00 305.25 ? 425 ASP A CA    1 
ATOM   2797 C C     . ASP A 1 425 ? 101.759 74.049  106.217 1.00 305.25 ? 425 ASP A C     1 
ATOM   2798 O O     . ASP A 1 425 ? 102.894 74.363  106.572 1.00 305.25 ? 425 ASP A O     1 
ATOM   2799 C CB    . ASP A 1 425 ? 101.111 76.034  104.842 1.00 305.25 ? 425 ASP A CB    1 
ATOM   2800 C CG    . ASP A 1 425 ? 101.126 75.313  103.504 1.00 305.25 ? 425 ASP A CG    1 
ATOM   2801 O OD1   . ASP A 1 425 ? 102.125 74.624  103.211 1.00 305.25 ? 425 ASP A OD1   1 
ATOM   2802 O OD2   . ASP A 1 425 ? 100.137 75.429  102.749 1.00 305.25 ? 425 ASP A OD2   1 
ATOM   2803 N N     . GLU A 1 426 ? 101.386 72.784  105.995 1.00 357.72 ? 426 GLU A N     1 
ATOM   2804 C CA    . GLU A 1 426 ? 102.265 71.685  106.376 1.00 357.72 ? 426 GLU A CA    1 
ATOM   2805 C C     . GLU A 1 426 ? 103.545 71.741  105.558 1.00 357.72 ? 426 GLU A C     1 
ATOM   2806 O O     . GLU A 1 426 ? 104.649 71.650  106.111 1.00 357.72 ? 426 GLU A O     1 
ATOM   2807 C CB    . GLU A 1 426 ? 101.548 70.350  106.179 1.00 357.72 ? 426 GLU A CB    1 
ATOM   2808 C CG    . GLU A 1 426 ? 100.106 70.360  106.663 1.00 357.72 ? 426 GLU A CG    1 
ATOM   2809 C CD    . GLU A 1 426 ? 99.381  69.063  106.365 1.00 357.72 ? 426 GLU A CD    1 
ATOM   2810 O OE1   . GLU A 1 426 ? 99.930  68.231  105.613 1.00 357.72 ? 426 GLU A OE1   1 
ATOM   2811 O OE2   . GLU A 1 426 ? 98.257  68.880  106.880 1.00 357.72 ? 426 GLU A OE2   1 
ATOM   2812 N N     . ILE A 1 427 ? 103.414 71.859  104.236 1.00 341.37 ? 427 ILE A N     1 
ATOM   2813 C CA    . ILE A 1 427 ? 104.586 71.905  103.371 1.00 341.37 ? 427 ILE A CA    1 
ATOM   2814 C C     . ILE A 1 427 ? 105.462 73.078  103.787 1.00 341.37 ? 427 ILE A C     1 
ATOM   2815 O O     . ILE A 1 427 ? 106.689 72.957  103.908 1.00 341.37 ? 427 ILE A O     1 
ATOM   2816 C CB    . ILE A 1 427 ? 104.166 71.991  101.892 1.00 341.37 ? 427 ILE A CB    1 
ATOM   2817 C CG1   . ILE A 1 427 ? 103.489 70.687  101.457 1.00 341.37 ? 427 ILE A CG1   1 
ATOM   2818 C CG2   . ILE A 1 427 ? 105.370 72.283  101.010 1.00 341.37 ? 427 ILE A CG2   1 
ATOM   2819 C CD1   . ILE A 1 427 ? 102.943 70.721  100.045 1.00 341.37 ? 427 ILE A CD1   1 
ATOM   2820 N N     . MET A 1 428 ? 104.824 74.215  104.075 1.00 277.65 ? 428 MET A N     1 
ATOM   2821 C CA    . MET A 1 428 ? 105.539 75.427  104.454 1.00 277.65 ? 428 MET A CA    1 
ATOM   2822 C C     . MET A 1 428 ? 106.235 75.240  105.793 1.00 277.65 ? 428 MET A C     1 
ATOM   2823 O O     . MET A 1 428 ? 107.398 75.623  105.956 1.00 277.65 ? 428 MET A O     1 
ATOM   2824 C CB    . MET A 1 428 ? 104.561 76.601  104.529 1.00 277.65 ? 428 MET A CB    1 
ATOM   2825 C CG    . MET A 1 428 ? 104.221 77.241  103.201 1.00 277.65 ? 428 MET A CG    1 
ATOM   2826 S SD    . MET A 1 428 ? 103.392 78.834  103.413 1.00 277.65 ? 428 MET A SD    1 
ATOM   2827 C CE    . MET A 1 428 ? 104.551 79.732  104.452 1.00 277.65 ? 428 MET A CE    1 
ATOM   2828 N N     . LEU A 1 429 ? 105.520 74.705  106.786 1.00 294.77 ? 429 LEU A N     1 
ATOM   2829 C CA    . LEU A 1 429 ? 106.125 74.534  108.104 1.00 294.77 ? 429 LEU A CA    1 
ATOM   2830 C C     . LEU A 1 429 ? 107.299 73.570  108.041 1.00 294.77 ? 429 LEU A C     1 
ATOM   2831 O O     . LEU A 1 429 ? 108.336 73.807  108.671 1.00 294.77 ? 429 LEU A O     1 
ATOM   2832 C CB    . LEU A 1 429 ? 105.103 74.035  109.122 1.00 294.77 ? 429 LEU A CB    1 
ATOM   2833 C CG    . LEU A 1 429 ? 103.919 74.912  109.506 1.00 294.77 ? 429 LEU A CG    1 
ATOM   2834 C CD1   . LEU A 1 429 ? 102.961 74.078  110.326 1.00 294.77 ? 429 LEU A CD1   1 
ATOM   2835 C CD2   . LEU A 1 429 ? 104.381 76.132  110.283 1.00 294.77 ? 429 LEU A CD2   1 
ATOM   2836 N N     . LYS A 1 430 ? 107.165 72.485  107.276 1.00 288.76 ? 430 LYS A N     1 
ATOM   2837 C CA    . LYS A 1 430 ? 108.272 71.542  107.147 1.00 288.76 ? 430 LYS A CA    1 
ATOM   2838 C C     . LYS A 1 430 ? 109.453 72.191  106.439 1.00 288.76 ? 430 LYS A C     1 
ATOM   2839 O O     . LYS A 1 430 ? 110.613 71.955  106.804 1.00 288.76 ? 430 LYS A O     1 
ATOM   2840 C CB    . LYS A 1 430 ? 107.805 70.296  106.396 1.00 288.76 ? 430 LYS A CB    1 
ATOM   2841 C CG    . LYS A 1 430 ? 108.907 69.306  106.069 1.00 288.76 ? 430 LYS A CG    1 
ATOM   2842 C CD    . LYS A 1 430 ? 108.376 68.170  105.213 1.00 288.76 ? 430 LYS A CD    1 
ATOM   2843 C CE    . LYS A 1 430 ? 109.483 67.213  104.807 1.00 288.76 ? 430 LYS A CE    1 
ATOM   2844 N NZ    . LYS A 1 430 ? 108.976 66.127  103.923 1.00 288.76 ? 430 LYS A NZ    1 
ATOM   2845 N N     . ALA A 1 431 ? 109.180 73.034  105.441 1.00 266.60 ? 431 ALA A N     1 
ATOM   2846 C CA    . ALA A 1 431 ? 110.265 73.703  104.736 1.00 266.60 ? 431 ALA A CA    1 
ATOM   2847 C C     . ALA A 1 431 ? 110.981 74.675  105.664 1.00 266.60 ? 431 ALA A C     1 
ATOM   2848 O O     . ALA A 1 431 ? 112.215 74.735  105.696 1.00 266.60 ? 431 ALA A O     1 
ATOM   2849 C CB    . ALA A 1 431 ? 109.724 74.425  103.501 1.00 266.60 ? 431 ALA A CB    1 
ATOM   2850 N N     . TYR A 1 432 ? 110.208 75.458  106.421 1.00 306.49 ? 432 TYR A N     1 
ATOM   2851 C CA    . TYR A 1 432 ? 110.781 76.370  107.404 1.00 306.49 ? 432 TYR A CA    1 
ATOM   2852 C C     . TYR A 1 432 ? 111.602 75.617  108.439 1.00 306.49 ? 432 TYR A C     1 
ATOM   2853 O O     . TYR A 1 432 ? 112.665 76.088  108.860 1.00 306.49 ? 432 TYR A O     1 
ATOM   2854 C CB    . TYR A 1 432 ? 109.668 77.167  108.074 1.00 306.49 ? 432 TYR A CB    1 
ATOM   2855 C CG    . TYR A 1 432 ? 109.298 78.386  107.281 1.00 306.49 ? 432 TYR A CG    1 
ATOM   2856 C CD1   . TYR A 1 432 ? 110.235 79.373  107.017 1.00 306.49 ? 432 TYR A CD1   1 
ATOM   2857 C CD2   . TYR A 1 432 ? 108.021 78.535  106.765 1.00 306.49 ? 432 TYR A CD2   1 
ATOM   2858 C CE1   . TYR A 1 432 ? 109.906 80.481  106.274 1.00 306.49 ? 432 TYR A CE1   1 
ATOM   2859 C CE2   . TYR A 1 432 ? 107.681 79.640  106.024 1.00 306.49 ? 432 TYR A CE2   1 
ATOM   2860 C CZ    . TYR A 1 432 ? 108.627 80.610  105.780 1.00 306.49 ? 432 TYR A CZ    1 
ATOM   2861 O OH    . TYR A 1 432 ? 108.290 81.712  105.043 1.00 306.49 ? 432 TYR A OH    1 
ATOM   2862 N N     . ASN A 1 433 ? 111.124 74.447  108.865 1.00 331.67 ? 433 ASN A N     1 
ATOM   2863 C CA    . ASN A 1 433 ? 111.845 73.687  109.872 1.00 331.67 ? 433 ASN A CA    1 
ATOM   2864 C C     . ASN A 1 433 ? 113.133 73.125  109.305 1.00 331.67 ? 433 ASN A C     1 
ATOM   2865 O O     . ASN A 1 433 ? 114.115 72.988  110.044 1.00 331.67 ? 433 ASN A O     1 
ATOM   2866 C CB    . ASN A 1 433 ? 110.968 72.558  110.418 1.00 331.67 ? 433 ASN A CB    1 
ATOM   2867 C CG    . ASN A 1 433 ? 109.748 73.070  111.156 1.00 331.67 ? 433 ASN A CG    1 
ATOM   2868 O OD1   . ASN A 1 433 ? 109.811 74.081  111.857 1.00 331.67 ? 433 ASN A OD1   1 
ATOM   2869 N ND2   . ASN A 1 433 ? 108.626 72.381  110.996 1.00 331.67 ? 433 ASN A ND2   1 
ATOM   2870 N N     . ASN A 1 434 ? 113.145 72.799  108.013 1.00 329.48 ? 434 ASN A N     1 
ATOM   2871 C CA    . ASN A 1 434 ? 114.362 72.427  107.304 1.00 329.48 ? 434 ASN A CA    1 
ATOM   2872 C C     . ASN A 1 434 ? 115.135 73.657  106.836 1.00 329.48 ? 434 ASN A C     1 
ATOM   2873 O O     . ASN A 1 434 ? 116.136 73.520  106.125 1.00 329.48 ? 434 ASN A O     1 
ATOM   2874 C CB    . ASN A 1 434 ? 114.022 71.524  106.120 1.00 329.48 ? 434 ASN A CB    1 
ATOM   2875 C CG    . ASN A 1 434 ? 113.525 70.160  106.553 1.00 329.48 ? 434 ASN A CG    1 
ATOM   2876 O OD1   . ASN A 1 434 ? 114.059 69.560  107.486 1.00 329.48 ? 434 ASN A OD1   1 
ATOM   2877 N ND2   . ASN A 1 434 ? 112.494 69.666  105.880 1.00 329.48 ? 434 ASN A ND2   1 
ATOM   2878 N N     . ASN A 1 435 ? 114.676 74.855  107.213 1.00 267.67 ? 435 ASN A N     1 
ATOM   2879 C CA    . ASN A 1 435 ? 115.341 76.114  106.872 1.00 267.67 ? 435 ASN A CA    1 
ATOM   2880 C C     . ASN A 1 435 ? 115.409 76.333  105.364 1.00 267.67 ? 435 ASN A C     1 
ATOM   2881 O O     . ASN A 1 435 ? 116.399 76.859  104.849 1.00 267.67 ? 435 ASN A O     1 
ATOM   2882 C CB    . ASN A 1 435 ? 116.741 76.192  107.489 1.00 267.67 ? 435 ASN A CB    1 
ATOM   2883 C CG    . ASN A 1 435 ? 116.709 76.222  109.002 1.00 267.67 ? 435 ASN A CG    1 
ATOM   2884 O OD1   . ASN A 1 435 ? 115.743 76.689  109.605 1.00 267.67 ? 435 ASN A OD1   1 
ATOM   2885 N ND2   . ASN A 1 435 ? 117.768 75.722  109.627 1.00 267.67 ? 435 ASN A ND2   1 
ATOM   2886 N N     . ILE A 1 436 ? 114.366 75.934  104.642 1.00 285.38 ? 436 ILE A N     1 
ATOM   2887 C CA    . ILE A 1 436 ? 114.266 76.215  103.215 1.00 285.38 ? 436 ILE A CA    1 
ATOM   2888 C C     . ILE A 1 436 ? 113.491 77.510  102.997 1.00 285.38 ? 436 ILE A C     1 
ATOM   2889 O O     . ILE A 1 436 ? 112.414 77.707  103.569 1.00 285.38 ? 436 ILE A O     1 
ATOM   2890 C CB    . ILE A 1 436 ? 113.596 75.046  102.478 1.00 285.38 ? 436 ILE A CB    1 
ATOM   2891 C CG1   . ILE A 1 436 ? 114.551 73.854  102.398 1.00 285.38 ? 436 ILE A CG1   1 
ATOM   2892 C CG2   . ILE A 1 436 ? 113.138 75.478  101.093 1.00 285.38 ? 436 ILE A CG2   1 
ATOM   2893 C CD1   . ILE A 1 436 ? 113.910 72.595  101.862 1.00 285.38 ? 436 ILE A CD1   1 
ATOM   2894 N N     . ASP A 1 437 ? 114.054 78.393  102.173 1.00 359.98 ? 437 ASP A N     1 
ATOM   2895 C CA    . ASP A 1 437 ? 113.447 79.687  101.888 1.00 359.98 ? 437 ASP A CA    1 
ATOM   2896 C C     . ASP A 1 437 ? 112.110 79.532  101.171 1.00 359.98 ? 437 ASP A C     1 
ATOM   2897 O O     . ASP A 1 437 ? 111.972 78.714  100.257 1.00 359.98 ? 437 ASP A O     1 
ATOM   2898 C CB    . ASP A 1 437 ? 114.404 80.532  101.048 1.00 359.98 ? 437 ASP A CB    1 
ATOM   2899 C CG    . ASP A 1 437 ? 113.833 81.890  100.703 1.00 359.98 ? 437 ASP A CG    1 
ATOM   2900 O OD1   . ASP A 1 437 ? 113.720 82.740  101.611 1.00 359.98 ? 437 ASP A OD1   1 
ATOM   2901 O OD2   . ASP A 1 437 ? 113.507 82.113  99.519  1.00 359.98 ? 437 ASP A OD2   1 
ATOM   2902 N N     . LEU A 1 438 ? 111.120 80.323  101.594 1.00 403.12 ? 438 LEU A N     1 
ATOM   2903 C CA    . LEU A 1 438 ? 109.776 80.209  101.032 1.00 403.12 ? 438 LEU A CA    1 
ATOM   2904 C C     . LEU A 1 438 ? 109.745 80.616  99.563  1.00 403.12 ? 438 LEU A C     1 
ATOM   2905 O O     . LEU A 1 438 ? 108.986 80.046  98.766  1.00 403.12 ? 438 LEU A O     1 
ATOM   2906 C CB    . LEU A 1 438 ? 108.795 81.048  101.846 1.00 403.12 ? 438 LEU A CB    1 
ATOM   2907 C CG    . LEU A 1 438 ? 107.333 80.796  101.491 1.00 403.12 ? 438 LEU A CG    1 
ATOM   2908 C CD1   . LEU A 1 438 ? 106.915 79.459  102.040 1.00 403.12 ? 438 LEU A CD1   1 
ATOM   2909 C CD2   . LEU A 1 438 ? 106.454 81.911  102.048 1.00 403.12 ? 438 LEU A CD2   1 
ATOM   2910 N N     . HIS A 1 439 ? 110.600 81.563  99.176  1.00 374.28 ? 439 HIS A N     1 
ATOM   2911 C CA    . HIS A 1 439 ? 110.637 82.001  97.786  1.00 374.28 ? 439 HIS A CA    1 
ATOM   2912 C C     . HIS A 1 439 ? 111.353 80.988  96.908  1.00 374.28 ? 439 HIS A C     1 
ATOM   2913 O O     . HIS A 1 439 ? 110.922 80.727  95.782  1.00 374.28 ? 439 HIS A O     1 
ATOM   2914 C CB    . HIS A 1 439 ? 111.301 83.373  97.666  1.00 374.28 ? 439 HIS A CB    1 
ATOM   2915 C CG    . HIS A 1 439 ? 110.684 84.429  98.530  1.00 374.28 ? 439 HIS A CG    1 
ATOM   2916 N ND1   . HIS A 1 439 ? 109.331 84.695  98.529  1.00 374.28 ? 439 HIS A ND1   1 
ATOM   2917 C CD2   . HIS A 1 439 ? 111.235 85.293  99.413  1.00 374.28 ? 439 HIS A CD2   1 
ATOM   2918 C CE1   . HIS A 1 439 ? 109.076 85.675  99.376  1.00 374.28 ? 439 HIS A CE1   1 
ATOM   2919 N NE2   . HIS A 1 439 ? 110.215 86.054  99.928  1.00 374.28 ? 439 HIS A NE2   1 
ATOM   2920 N N     . THR A 1 440 ? 112.450 80.405  97.395  1.00 382.77 ? 440 THR A N     1 
ATOM   2921 C CA    . THR A 1 440 ? 113.028 79.269  96.685  1.00 382.77 ? 440 THR A CA    1 
ATOM   2922 C C     . THR A 1 440 ? 111.993 78.161  96.505  1.00 382.77 ? 440 THR A C     1 
ATOM   2923 O O     . THR A 1 440 ? 111.896 77.563  95.427  1.00 382.77 ? 440 THR A O     1 
ATOM   2924 C CB    . THR A 1 440 ? 114.253 78.748  97.433  1.00 382.77 ? 440 THR A CB    1 
ATOM   2925 O OG1   . THR A 1 440 ? 115.235 79.788  97.522  1.00 382.77 ? 440 THR A OG1   1 
ATOM   2926 C CG2   . THR A 1 440 ? 114.855 77.569  96.695  1.00 382.77 ? 440 THR A CG2   1 
ATOM   2927 N N     . LEU A 1 441 ? 111.247 77.847  97.567  1.00 407.18 ? 441 LEU A N     1 
ATOM   2928 C CA    . LEU A 1 441 ? 110.183 76.848  97.483  1.00 407.18 ? 441 LEU A CA    1 
ATOM   2929 C C     . LEU A 1 441 ? 109.215 77.165  96.345  1.00 407.18 ? 441 LEU A C     1 
ATOM   2930 O O     . LEU A 1 441 ? 108.964 76.327  95.466  1.00 407.18 ? 441 LEU A O     1 
ATOM   2931 C CB    . LEU A 1 441 ? 109.439 76.764  98.816  1.00 407.18 ? 441 LEU A CB    1 
ATOM   2932 C CG    . LEU A 1 441 ? 108.140 75.954  98.828  1.00 407.18 ? 441 LEU A CG    1 
ATOM   2933 C CD1   . LEU A 1 441 ? 108.390 74.512  98.405  1.00 407.18 ? 441 LEU A CD1   1 
ATOM   2934 C CD2   . LEU A 1 441 ? 107.483 76.007  100.202 1.00 407.18 ? 441 LEU A CD2   1 
ATOM   2935 N N     . THR A 1 442 ? 108.622 78.364  96.375  1.00 415.40 ? 442 THR A N     1 
ATOM   2936 C CA    . THR A 1 442 ? 107.649 78.724  95.350  1.00 415.40 ? 442 THR A CA    1 
ATOM   2937 C C     . THR A 1 442 ? 108.276 78.727  93.959  1.00 415.40 ? 442 THR A C     1 
ATOM   2938 O O     . THR A 1 442 ? 107.616 78.378  92.974  1.00 415.40 ? 442 THR A O     1 
ATOM   2939 C CB    . THR A 1 442 ? 107.040 80.090  95.670  1.00 415.40 ? 442 THR A CB    1 
ATOM   2940 O OG1   . THR A 1 442 ? 106.344 80.021  96.920  1.00 415.40 ? 442 THR A OG1   1 
ATOM   2941 C CG2   . THR A 1 442 ? 106.060 80.517  94.584  1.00 415.40 ? 442 THR A CG2   1 
ATOM   2942 N N     . ALA A 1 443 ? 109.544 79.137  93.853  1.00 370.20 ? 443 ALA A N     1 
ATOM   2943 C CA    . ALA A 1 443 ? 110.230 79.080  92.567  1.00 370.20 ? 443 ALA A CA    1 
ATOM   2944 C C     . ALA A 1 443 ? 110.332 77.647  92.068  1.00 370.20 ? 443 ALA A C     1 
ATOM   2945 O O     . ALA A 1 443 ? 110.143 77.374  90.877  1.00 370.20 ? 443 ALA A O     1 
ATOM   2946 C CB    . ALA A 1 443 ? 111.619 79.711  92.683  1.00 370.20 ? 443 ALA A CB    1 
ATOM   2947 N N     . SER A 1 444 ? 110.625 76.714  92.975  1.00 328.65 ? 444 SER A N     1 
ATOM   2948 C CA    . SER A 1 444 ? 110.720 75.310  92.598  1.00 328.65 ? 444 SER A CA    1 
ATOM   2949 C C     . SER A 1 444 ? 109.359 74.745  92.220  1.00 328.65 ? 444 SER A C     1 
ATOM   2950 O O     . SER A 1 444 ? 109.267 73.780  91.454  1.00 328.65 ? 444 SER A O     1 
ATOM   2951 C CB    . SER A 1 444 ? 111.336 74.505  93.742  1.00 328.65 ? 444 SER A CB    1 
ATOM   2952 O OG    . SER A 1 444 ? 110.436 74.397  94.829  1.00 328.65 ? 444 SER A OG    1 
ATOM   2953 N N     . ILE A 1 445 ? 108.286 75.334  92.751  1.00 324.24 ? 445 ILE A N     1 
ATOM   2954 C CA    . ILE A 1 445 ? 106.951 74.867  92.383  1.00 324.24 ? 445 ILE A CA    1 
ATOM   2955 C C     . ILE A 1 445 ? 106.532 75.425  91.025  1.00 324.24 ? 445 ILE A C     1 
ATOM   2956 O O     . ILE A 1 445 ? 105.969 74.705  90.191  1.00 324.24 ? 445 ILE A O     1 
ATOM   2957 C CB    . ILE A 1 445 ? 105.938 75.224  93.484  1.00 324.24 ? 445 ILE A CB    1 
ATOM   2958 C CG1   . ILE A 1 445 ? 106.223 74.414  94.748  1.00 324.24 ? 445 ILE A CG1   1 
ATOM   2959 C CG2   . ILE A 1 445 ? 104.514 74.985  93.006  1.00 324.24 ? 445 ILE A CG2   1 
ATOM   2960 C CD1   . ILE A 1 445 ? 105.391 74.823  95.939  1.00 324.24 ? 445 ILE A CD1   1 
ATOM   2961 N N     . ILE A 1 446 ? 106.803 76.706  90.777  1.00 345.58 ? 446 ILE A N     1 
ATOM   2962 C CA    . ILE A 1 446 ? 106.400 77.326  89.515  1.00 345.58 ? 446 ILE A CA    1 
ATOM   2963 C C     . ILE A 1 446 ? 107.247 76.806  88.356  1.00 345.58 ? 446 ILE A C     1 
ATOM   2964 O O     . ILE A 1 446 ? 106.709 76.420  87.312  1.00 345.58 ? 446 ILE A O     1 
ATOM   2965 C CB    . ILE A 1 446 ? 106.438 78.863  89.604  1.00 345.58 ? 446 ILE A CB    1 
ATOM   2966 C CG1   . ILE A 1 446 ? 107.829 79.367  89.989  1.00 345.58 ? 446 ILE A CG1   1 
ATOM   2967 C CG2   . ILE A 1 446 ? 105.393 79.361  90.592  1.00 345.58 ? 446 ILE A CG2   1 
ATOM   2968 C CD1   . ILE A 1 446 ? 108.027 80.847  89.783  1.00 345.58 ? 446 ILE A CD1   1 
ATOM   2969 N N     . THR A 1 447 ? 108.570 76.789  88.516  1.00 333.25 ? 447 THR A N     1 
ATOM   2970 C CA    . THR A 1 447 ? 109.507 76.416  87.467  1.00 333.25 ? 447 THR A CA    1 
ATOM   2971 C C     . THR A 1 447 ? 109.662 74.911  87.321  1.00 333.25 ? 447 THR A C     1 
ATOM   2972 O O     . THR A 1 447 ? 110.187 74.459  86.296  1.00 333.25 ? 447 THR A O     1 
ATOM   2973 C CB    . THR A 1 447 ? 110.881 77.045  87.727  1.00 333.25 ? 447 THR A CB    1 
ATOM   2974 O OG1   . THR A 1 447 ? 111.493 76.411  88.857  1.00 333.25 ? 447 THR A OG1   1 
ATOM   2975 C CG2   . THR A 1 447 ? 110.750 78.540  87.983  1.00 333.25 ? 447 THR A CG2   1 
ATOM   2976 N N     . LYS A 1 448 ? 109.252 74.136  88.328  1.00 382.11 ? 448 LYS A N     1 
ATOM   2977 C CA    . LYS A 1 448 ? 109.467 72.694  88.405  1.00 382.11 ? 448 LYS A CA    1 
ATOM   2978 C C     . LYS A 1 448 ? 110.937 72.323  88.564  1.00 382.11 ? 448 LYS A C     1 
ATOM   2979 O O     . LYS A 1 448 ? 111.301 71.155  88.403  1.00 382.11 ? 448 LYS A O     1 
ATOM   2980 C CB    . LYS A 1 448 ? 108.866 71.965  87.196  1.00 382.11 ? 448 LYS A CB    1 
ATOM   2981 C CG    . LYS A 1 448 ? 107.361 72.139  87.060  1.00 382.11 ? 448 LYS A CG    1 
ATOM   2982 C CD    . LYS A 1 448 ? 106.833 71.451  85.812  1.00 382.11 ? 448 LYS A CD    1 
ATOM   2983 C CE    . LYS A 1 448 ? 105.345 71.706  85.630  1.00 382.11 ? 448 LYS A CE    1 
ATOM   2984 N NZ    . LYS A 1 448 ? 104.768 70.881  84.533  1.00 382.11 ? 448 LYS A NZ    1 
ATOM   2985 N N     . LYS A 1 449 ? 111.792 73.292  88.876  1.00 373.59 ? 449 LYS A N     1 
ATOM   2986 C CA    . LYS A 1 449 ? 113.197 73.012  89.113  1.00 373.59 ? 449 LYS A CA    1 
ATOM   2987 C C     . LYS A 1 449 ? 113.368 72.542  90.551  1.00 373.59 ? 449 LYS A C     1 
ATOM   2988 O O     . LYS A 1 449 ? 112.501 72.759  91.401  1.00 373.59 ? 449 LYS A O     1 
ATOM   2989 C CB    . LYS A 1 449 ? 114.058 74.252  88.868  1.00 373.59 ? 449 LYS A CB    1 
ATOM   2990 C CG    . LYS A 1 449 ? 113.934 74.845  87.478  1.00 373.59 ? 449 LYS A CG    1 
ATOM   2991 C CD    . LYS A 1 449 ? 114.852 76.046  87.325  1.00 373.59 ? 449 LYS A CD    1 
ATOM   2992 C CE    . LYS A 1 449 ? 114.573 76.802  86.039  1.00 373.59 ? 449 LYS A CE    1 
ATOM   2993 N NZ    . LYS A 1 449 ? 115.387 78.045  85.947  1.00 373.59 ? 449 LYS A NZ    1 
ATOM   2994 N N     . ASN A 1 450 ? 114.493 71.888  90.820  1.00 400.29 ? 450 ASN A N     1 
ATOM   2995 C CA    . ASN A 1 450 ? 114.852 71.575  92.194  1.00 400.29 ? 450 ASN A CA    1 
ATOM   2996 C C     . ASN A 1 450 ? 115.568 72.738  92.872  1.00 400.29 ? 450 ASN A C     1 
ATOM   2997 O O     . ASN A 1 450 ? 116.146 73.613  92.221  1.00 400.29 ? 450 ASN A O     1 
ATOM   2998 C CB    . ASN A 1 450 ? 115.733 70.328  92.238  1.00 400.29 ? 450 ASN A CB    1 
ATOM   2999 C CG    . ASN A 1 450 ? 115.056 69.115  91.635  1.00 400.29 ? 450 ASN A CG    1 
ATOM   3000 O OD1   . ASN A 1 450 ? 113.882 68.852  91.895  1.00 400.29 ? 450 ASN A OD1   1 
ATOM   3001 N ND2   . ASN A 1 450 ? 115.795 68.368  90.824  1.00 400.29 ? 450 ASN A ND2   1 
ATOM   3002 N N     . ILE A 1 451 ? 115.495 72.738  94.210  1.00 341.05 ? 451 ILE A N     1 
ATOM   3003 C CA    . ILE A 1 451 ? 115.977 73.888  94.984  1.00 341.05 ? 451 ILE A CA    1 
ATOM   3004 C C     . ILE A 1 451 ? 117.429 74.232  94.663  1.00 341.05 ? 451 ILE A C     1 
ATOM   3005 O O     . ILE A 1 451 ? 117.753 75.427  94.590  1.00 341.05 ? 451 ILE A O     1 
ATOM   3006 C CB    . ILE A 1 451 ? 115.732 73.648  96.480  1.00 341.05 ? 451 ILE A CB    1 
ATOM   3007 C CG1   . ILE A 1 451 ? 114.249 73.849  96.806  1.00 341.05 ? 451 ILE A CG1   1 
ATOM   3008 C CG2   . ILE A 1 451 ? 116.619 74.541  97.339  1.00 341.05 ? 451 ILE A CG2   1 
ATOM   3009 C CD1   . ILE A 1 451 ? 113.880 73.471  98.217  1.00 341.05 ? 451 ILE A CD1   1 
ATOM   3010 N N     . PRO A 1 452 ? 118.339 73.272  94.438  1.00 364.07 ? 452 PRO A N     1 
ATOM   3011 C CA    . PRO A 1 452 ? 119.720 73.649  94.083  1.00 364.07 ? 452 PRO A CA    1 
ATOM   3012 C C     . PRO A 1 452 ? 119.835 74.364  92.749  1.00 364.07 ? 452 PRO A C     1 
ATOM   3013 O O     . PRO A 1 452 ? 120.818 75.086  92.538  1.00 364.07 ? 452 PRO A O     1 
ATOM   3014 C CB    . PRO A 1 452 ? 120.465 72.306  94.065  1.00 364.07 ? 452 PRO A CB    1 
ATOM   3015 C CG    . PRO A 1 452 ? 119.651 71.408  94.905  1.00 364.07 ? 452 PRO A CG    1 
ATOM   3016 C CD    . PRO A 1 452 ? 118.237 71.824  94.701  1.00 364.07 ? 452 PRO A CD    1 
ATOM   3017 N N     . ASP A 1 453 ? 118.868 74.195  91.852  1.00 334.13 ? 453 ASP A N     1 
ATOM   3018 C CA    . ASP A 1 453 ? 118.908 74.792  90.523  1.00 334.13 ? 453 ASP A CA    1 
ATOM   3019 C C     . ASP A 1 453 ? 118.095 76.075  90.420  1.00 334.13 ? 453 ASP A C     1 
ATOM   3020 O O     . ASP A 1 453 ? 117.773 76.500  89.306  1.00 334.13 ? 453 ASP A O     1 
ATOM   3021 C CB    . ASP A 1 453 ? 118.412 73.783  89.484  1.00 334.13 ? 453 ASP A CB    1 
ATOM   3022 C CG    . ASP A 1 453 ? 119.296 72.557  89.397  1.00 334.13 ? 453 ASP A CG    1 
ATOM   3023 O OD1   . ASP A 1 453 ? 120.517 72.715  89.187  1.00 334.13 ? 453 ASP A OD1   1 
ATOM   3024 O OD2   . ASP A 1 453 ? 118.771 71.433  89.547  1.00 334.13 ? 453 ASP A OD2   1 
ATOM   3025 N N     . ILE A 1 454 ? 117.756 76.696  91.545  1.00 326.87 ? 454 ILE A N     1 
ATOM   3026 C CA    . ILE A 1 454 ? 116.951 77.913  91.546  1.00 326.87 ? 454 ILE A CA    1 
ATOM   3027 C C     . ILE A 1 454 ? 117.902 79.093  91.708  1.00 326.87 ? 454 ILE A C     1 
ATOM   3028 O O     . ILE A 1 454 ? 118.668 79.160  92.675  1.00 326.87 ? 454 ILE A O     1 
ATOM   3029 C CB    . ILE A 1 454 ? 115.897 77.884  92.662  1.00 326.87 ? 454 ILE A CB    1 
ATOM   3030 C CG1   . ILE A 1 454 ? 114.691 77.045  92.238  1.00 326.87 ? 454 ILE A CG1   1 
ATOM   3031 C CG2   . ILE A 1 454 ? 115.454 79.294  93.020  1.00 326.87 ? 454 ILE A CG2   1 
ATOM   3032 C CD1   . ILE A 1 454 ? 114.028 77.528  90.967  1.00 326.87 ? 454 ILE A CD1   1 
ATOM   3033 N N     . ASN A 1 455 ? 117.860 80.022  90.756  1.00 378.85 ? 455 ASN A N     1 
ATOM   3034 C CA    . ASN A 1 455 ? 118.744 81.177  90.724  1.00 378.85 ? 455 ASN A CA    1 
ATOM   3035 C C     . ASN A 1 455 ? 118.048 82.409  91.296  1.00 378.85 ? 455 ASN A C     1 
ATOM   3036 O O     . ASN A 1 455 ? 116.858 82.392  91.621  1.00 378.85 ? 455 ASN A O     1 
ATOM   3037 C CB    . ASN A 1 455 ? 119.233 81.437  89.297  1.00 378.85 ? 455 ASN A CB    1 
ATOM   3038 C CG    . ASN A 1 455 ? 118.095 81.559  88.301  1.00 378.85 ? 455 ASN A CG    1 
ATOM   3039 O OD1   . ASN A 1 455 ? 117.248 82.445  88.412  1.00 378.85 ? 455 ASN A OD1   1 
ATOM   3040 N ND2   . ASN A 1 455 ? 118.071 80.664  87.322  1.00 378.85 ? 455 ASN A ND2   1 
ATOM   3041 N N     . LYS A 1 456 ? 118.819 83.492  91.439  1.00 392.65 ? 456 LYS A N     1 
ATOM   3042 C CA    . LYS A 1 456 ? 118.298 84.691  92.088  1.00 392.65 ? 456 LYS A CA    1 
ATOM   3043 C C     . LYS A 1 456 ? 117.119 85.275  91.323  1.00 392.65 ? 456 LYS A C     1 
ATOM   3044 O O     . LYS A 1 456 ? 116.187 85.812  91.933  1.00 392.65 ? 456 LYS A O     1 
ATOM   3045 C CB    . LYS A 1 456 ? 119.405 85.734  92.236  1.00 392.65 ? 456 LYS A CB    1 
ATOM   3046 C CG    . LYS A 1 456 ? 120.562 85.293  93.111  1.00 392.65 ? 456 LYS A CG    1 
ATOM   3047 C CD    . LYS A 1 456 ? 121.613 86.383  93.219  1.00 392.65 ? 456 LYS A CD    1 
ATOM   3048 C CE    . LYS A 1 456 ? 122.778 85.943  94.090  1.00 392.65 ? 456 LYS A CE    1 
ATOM   3049 N NZ    . LYS A 1 456 ? 123.812 87.006  94.206  1.00 392.65 ? 456 LYS A NZ    1 
ATOM   3050 N N     . GLU A 1 457 ? 117.146 85.214  89.988  1.00 389.83 ? 457 GLU A N     1 
ATOM   3051 C CA    . GLU A 1 457 ? 116.008 85.730  89.232  1.00 389.83 ? 457 GLU A CA    1 
ATOM   3052 C C     . GLU A 1 457 ? 114.768 84.892  89.513  1.00 389.83 ? 457 GLU A C     1 
ATOM   3053 O O     . GLU A 1 457 ? 113.652 85.424  89.617  1.00 389.83 ? 457 GLU A O     1 
ATOM   3054 C CB    . GLU A 1 457 ? 116.334 85.743  87.740  1.00 389.83 ? 457 GLU A CB    1 
ATOM   3055 C CG    . GLU A 1 457 ? 115.216 86.275  86.860  1.00 389.83 ? 457 GLU A CG    1 
ATOM   3056 C CD    . GLU A 1 457 ? 115.582 86.259  85.389  1.00 389.83 ? 457 GLU A CD    1 
ATOM   3057 O OE1   . GLU A 1 457 ? 116.667 85.742  85.051  1.00 389.83 ? 457 GLU A OE1   1 
ATOM   3058 O OE2   . GLU A 1 457 ? 114.785 86.764  84.571  1.00 389.83 ? 457 GLU A OE2   1 
ATOM   3059 N N     . ASP A 1 458 ? 114.959 83.580  89.676  1.00 386.07 ? 458 ASP A N     1 
ATOM   3060 C CA    . ASP A 1 458 ? 113.859 82.696  90.041  1.00 386.07 ? 458 ASP A CA    1 
ATOM   3061 C C     . ASP A 1 458 ? 113.284 83.103  91.387  1.00 386.07 ? 458 ASP A C     1 
ATOM   3062 O O     . ASP A 1 458 ? 112.062 83.178  91.559  1.00 386.07 ? 458 ASP A O     1 
ATOM   3063 C CB    . ASP A 1 458 ? 114.324 81.239  90.067  1.00 386.07 ? 458 ASP A CB    1 
ATOM   3064 C CG    . ASP A 1 458 ? 114.706 80.722  88.696  1.00 386.07 ? 458 ASP A CG    1 
ATOM   3065 O OD1   . ASP A 1 458 ? 114.085 81.153  87.702  1.00 386.07 ? 458 ASP A OD1   1 
ATOM   3066 O OD2   . ASP A 1 458 ? 115.615 79.871  88.614  1.00 386.07 ? 458 ASP A OD2   1 
ATOM   3067 N N     . ARG A 1 459 ? 114.160 83.378  92.358  1.00 356.53 ? 459 ARG A N     1 
ATOM   3068 C CA    . ARG A 1 459 ? 113.679 83.752  93.681  1.00 356.53 ? 459 ARG A CA    1 
ATOM   3069 C C     . ARG A 1 459 ? 112.974 85.100  93.636  1.00 356.53 ? 459 ARG A C     1 
ATOM   3070 O O     . ARG A 1 459 ? 112.007 85.317  94.365  1.00 356.53 ? 459 ARG A O     1 
ATOM   3071 C CB    . ARG A 1 459 ? 114.843 83.786  94.673  1.00 356.53 ? 459 ARG A CB    1 
ATOM   3072 C CG    . ARG A 1 459 ? 114.430 84.121  96.094  1.00 356.53 ? 459 ARG A CG    1 
ATOM   3073 C CD    . ARG A 1 459 ? 115.630 84.455  96.961  1.00 356.53 ? 459 ARG A CD    1 
ATOM   3074 N NE    . ARG A 1 459 ? 115.229 84.811  98.316  1.00 356.53 ? 459 ARG A NE    1 
ATOM   3075 C CZ    . ARG A 1 459 ? 115.251 86.044  98.805  1.00 356.53 ? 459 ARG A CZ    1 
ATOM   3076 N NH1   . ARG A 1 459 ? 114.887 86.248  100.068 1.00 356.53 ? 459 ARG A NH1   1 
ATOM   3077 N NH2   . ARG A 1 459 ? 115.612 87.076  98.060  1.00 356.53 ? 459 ARG A NH2   1 
ATOM   3078 N N     . HIS A 1 460 ? 113.479 86.038  92.833  1.00 322.82 ? 460 HIS A N     1 
ATOM   3079 C CA    . HIS A 1 460 ? 112.840 87.349  92.737  1.00 322.82 ? 460 HIS A CA    1 
ATOM   3080 C C     . HIS A 1 460 ? 111.429 87.223  92.175  1.00 322.82 ? 460 HIS A C     1 
ATOM   3081 O O     . HIS A 1 460 ? 110.467 87.797  92.714  1.00 322.82 ? 460 HIS A O     1 
ATOM   3082 C CB    . HIS A 1 460 ? 113.687 88.278  91.868  1.00 322.82 ? 460 HIS A CB    1 
ATOM   3083 C CG    . HIS A 1 460 ? 113.356 89.728  92.032  1.00 322.82 ? 460 HIS A CG    1 
ATOM   3084 N ND1   . HIS A 1 460 ? 113.328 90.353  93.259  1.00 322.82 ? 460 HIS A ND1   1 
ATOM   3085 C CD2   . HIS A 1 460 ? 113.042 90.679  91.120  1.00 322.82 ? 460 HIS A CD2   1 
ATOM   3086 C CE1   . HIS A 1 460 ? 113.008 91.624  93.098  1.00 322.82 ? 460 HIS A CE1   1 
ATOM   3087 N NE2   . HIS A 1 460 ? 112.830 91.848  91.809  1.00 322.82 ? 460 HIS A NE2   1 
ATOM   3088 N N     . ILE A 1 461 ? 111.288 86.454  91.090  1.00 423.85 ? 461 ILE A N     1 
ATOM   3089 C CA    . ILE A 1 461 ? 109.965 86.185  90.533  1.00 423.85 ? 461 ILE A CA    1 
ATOM   3090 C C     . ILE A 1 461 ? 109.078 85.509  91.569  1.00 423.85 ? 461 ILE A C     1 
ATOM   3091 O O     . ILE A 1 461 ? 107.896 85.844  91.715  1.00 423.85 ? 461 ILE A O     1 
ATOM   3092 C CB    . ILE A 1 461 ? 110.096 85.329  89.259  1.00 423.85 ? 461 ILE A CB    1 
ATOM   3093 C CG1   . ILE A 1 461 ? 110.805 86.117  88.154  1.00 423.85 ? 461 ILE A CG1   1 
ATOM   3094 C CG2   . ILE A 1 461 ? 108.744 84.799  88.812  1.00 423.85 ? 461 ILE A CG2   1 
ATOM   3095 C CD1   . ILE A 1 461 ? 111.046 85.316  86.894  1.00 423.85 ? 461 ILE A CD1   1 
ATOM   3096 N N     . ALA A 1 462 ? 109.634 84.542  92.304  1.00 409.96 ? 462 ALA A N     1 
ATOM   3097 C CA    . ALA A 1 462 ? 108.827 83.836  93.289  1.00 409.96 ? 462 ALA A CA    1 
ATOM   3098 C C     . ALA A 1 462 ? 108.409 84.772  94.411  1.00 409.96 ? 462 ALA A C     1 
ATOM   3099 O O     . ALA A 1 462 ? 107.321 84.632  94.969  1.00 409.96 ? 462 ALA A O     1 
ATOM   3100 C CB    . ALA A 1 462 ? 109.598 82.639  93.836  1.00 409.96 ? 462 ALA A CB    1 
ATOM   3101 N N     . LYS A 1 463 ? 109.293 85.694  94.787  1.00 343.42 ? 463 LYS A N     1 
ATOM   3102 C CA    . LYS A 1 463 ? 108.968 86.722  95.768  1.00 343.42 ? 463 LYS A CA    1 
ATOM   3103 C C     . LYS A 1 463 ? 107.748 87.515  95.327  1.00 343.42 ? 463 LYS A C     1 
ATOM   3104 O O     . LYS A 1 463 ? 106.809 87.730  96.105  1.00 343.42 ? 463 LYS A O     1 
ATOM   3105 C CB    . LYS A 1 463 ? 110.177 87.635  95.968  1.00 343.42 ? 463 LYS A CB    1 
ATOM   3106 C CG    . LYS A 1 463 ? 110.000 88.709  97.018  1.00 343.42 ? 463 LYS A CG    1 
ATOM   3107 C CD    . LYS A 1 463 ? 111.183 89.663  97.027  1.00 343.42 ? 463 LYS A CD    1 
ATOM   3108 C CE    . LYS A 1 463 ? 111.027 90.729  98.097  1.00 343.42 ? 463 LYS A CE    1 
ATOM   3109 N NZ    . LYS A 1 463 ? 112.153 91.703  98.077  1.00 343.42 ? 463 LYS A NZ    1 
ATOM   3110 N N     . ALA A 1 464 ? 107.755 87.964  94.067  1.00 384.83 ? 464 ALA A N     1 
ATOM   3111 C CA    . ALA A 1 464 ? 106.630 88.759  93.584  1.00 384.83 ? 464 ALA A CA    1 
ATOM   3112 C C     . ALA A 1 464 ? 105.356 87.925  93.554  1.00 384.83 ? 464 ALA A C     1 
ATOM   3113 O O     . ALA A 1 464 ? 104.286 88.389  93.972  1.00 384.83 ? 464 ALA A O     1 
ATOM   3114 C CB    . ALA A 1 464 ? 106.939 89.322  92.197  1.00 384.83 ? 464 ALA A CB    1 
ATOM   3115 N N     . ILE A 1 465 ? 105.475 86.661  93.141  1.00 450.89 ? 465 ILE A N     1 
ATOM   3116 C CA    . ILE A 1 465 ? 104.318 85.771  93.089  1.00 450.89 ? 465 ILE A CA    1 
ATOM   3117 C C     . ILE A 1 465 ? 103.769 85.557  94.491  1.00 450.89 ? 465 ILE A C     1 
ATOM   3118 O O     . ILE A 1 465 ? 102.554 85.579  94.714  1.00 450.89 ? 465 ILE A O     1 
ATOM   3119 C CB    . ILE A 1 465 ? 104.683 84.442  92.405  1.00 450.89 ? 465 ILE A CB    1 
ATOM   3120 C CG1   . ILE A 1 465 ? 105.062 84.689  90.946  1.00 450.89 ? 465 ILE A CG1   1 
ATOM   3121 C CG2   . ILE A 1 465 ? 103.528 83.457  92.498  1.00 450.89 ? 465 ILE A CG2   1 
ATOM   3122 C CD1   . ILE A 1 465 ? 105.624 83.480  90.250  1.00 450.89 ? 465 ILE A CD1   1 
ATOM   3123 N N     . ASN A 1 466 ? 104.663 85.325  95.450  1.00 387.53 ? 466 ASN A N     1 
ATOM   3124 C CA    . ASN A 1 466 ? 104.270 85.024  96.816  1.00 387.53 ? 466 ASN A CA    1 
ATOM   3125 C C     . ASN A 1 466 ? 103.539 86.209  97.415  1.00 387.53 ? 466 ASN A C     1 
ATOM   3126 O O     . ASN A 1 466 ? 102.409 86.078  97.894  1.00 387.53 ? 466 ASN A O     1 
ATOM   3127 C CB    . ASN A 1 466 ? 105.497 84.656  97.649  1.00 387.53 ? 466 ASN A CB    1 
ATOM   3128 C CG    . ASN A 1 466 ? 105.894 83.205  97.488  1.00 387.53 ? 466 ASN A CG    1 
ATOM   3129 O OD1   . ASN A 1 466 ? 105.086 82.374  97.073  1.00 387.53 ? 466 ASN A OD1   1 
ATOM   3130 N ND2   . ASN A 1 466 ? 107.141 82.889  97.816  1.00 387.53 ? 466 ASN A ND2   1 
ATOM   3131 N N     . PHE A 1 467 ? 104.170 87.384  97.407  1.00 384.97 ? 467 PHE A N     1 
ATOM   3132 C CA    . PHE A 1 467 ? 103.492 88.534  97.991  1.00 384.97 ? 467 PHE A CA    1 
ATOM   3133 C C     . PHE A 1 467 ? 102.189 88.855  97.267  1.00 384.97 ? 467 PHE A C     1 
ATOM   3134 O O     . PHE A 1 467 ? 101.235 89.308  97.911  1.00 384.97 ? 467 PHE A O     1 
ATOM   3135 C CB    . PHE A 1 467 ? 104.410 89.754  98.010  1.00 384.97 ? 467 PHE A CB    1 
ATOM   3136 C CG    . PHE A 1 467 ? 105.523 89.658  99.013  1.00 384.97 ? 467 PHE A CG    1 
ATOM   3137 C CD1   . PHE A 1 467 ? 105.245 89.704  100.369 1.00 384.97 ? 467 PHE A CD1   1 
ATOM   3138 C CD2   . PHE A 1 467 ? 106.840 89.534  98.609  1.00 384.97 ? 467 PHE A CD2   1 
ATOM   3139 C CE1   . PHE A 1 467 ? 106.256 89.621  101.303 1.00 384.97 ? 467 PHE A CE1   1 
ATOM   3140 C CE2   . PHE A 1 467 ? 107.857 89.451  99.543  1.00 384.97 ? 467 PHE A CE2   1 
ATOM   3141 C CZ    . PHE A 1 467 ? 107.564 89.495  100.890 1.00 384.97 ? 467 PHE A CZ    1 
ATOM   3142 N N     . GLY A 1 468 ? 102.103 88.638  95.951  1.00 424.12 ? 468 GLY A N     1 
ATOM   3143 C CA    . GLY A 1 468 ? 100.863 88.969  95.272  1.00 424.12 ? 468 GLY A CA    1 
ATOM   3144 C C     . GLY A 1 468 ? 99.739  87.988  95.562  1.00 424.12 ? 468 GLY A C     1 
ATOM   3145 O O     . GLY A 1 468 ? 98.634  88.392  95.931  1.00 424.12 ? 468 GLY A O     1 
ATOM   3146 N N     . LEU A 1 469 ? 100.007 86.687  95.418  1.00 438.79 ? 469 LEU A N     1 
ATOM   3147 C CA    . LEU A 1 469 ? 98.975  85.663  95.550  1.00 438.79 ? 469 LEU A CA    1 
ATOM   3148 C C     . LEU A 1 469 ? 98.654  85.311  96.998  1.00 438.79 ? 469 LEU A C     1 
ATOM   3149 O O     . LEU A 1 469 ? 97.491  85.050  97.324  1.00 438.79 ? 469 LEU A O     1 
ATOM   3150 C CB    . LEU A 1 469 ? 99.387  84.405  94.783  1.00 438.79 ? 469 LEU A CB    1 
ATOM   3151 C CG    . LEU A 1 469 ? 99.539  84.617  93.276  1.00 438.79 ? 469 LEU A CG    1 
ATOM   3152 C CD1   . LEU A 1 469 ? 99.755  83.298  92.557  1.00 438.79 ? 469 LEU A CD1   1 
ATOM   3153 C CD2   . LEU A 1 469 ? 98.315  85.331  92.723  1.00 438.79 ? 469 LEU A CD2   1 
ATOM   3154 N N     . ILE A 1 470 ? 99.666  85.289  97.872  1.00 428.39 ? 470 ILE A N     1 
ATOM   3155 C CA    . ILE A 1 470 ? 99.444  84.973  99.278  1.00 428.39 ? 470 ILE A CA    1 
ATOM   3156 C C     . ILE A 1 470 ? 98.495  85.981  99.902  1.00 428.39 ? 470 ILE A C     1 
ATOM   3157 O O     . ILE A 1 470 ? 97.716  85.645  100.800 1.00 428.39 ? 470 ILE A O     1 
ATOM   3158 C CB    . ILE A 1 470 ? 100.790 84.909  100.031 1.00 428.39 ? 470 ILE A CB    1 
ATOM   3159 C CG1   . ILE A 1 470 ? 101.576 83.660  99.627  1.00 428.39 ? 470 ILE A CG1   1 
ATOM   3160 C CG2   . ILE A 1 470 ? 100.584 84.926  101.539 1.00 428.39 ? 470 ILE A CG2   1 
ATOM   3161 C CD1   . ILE A 1 470 ? 102.987 83.626  100.165 1.00 428.39 ? 470 ILE A CD1   1 
ATOM   3162 N N     . TYR A 1 471 ? 98.519  87.221  99.417  1.00 382.34 ? 471 TYR A N     1 
ATOM   3163 C CA    . TYR A 1 471 ? 97.690  88.278  99.972  1.00 382.34 ? 471 TYR A CA    1 
ATOM   3164 C C     . TYR A 1 471 ? 96.408  88.480  99.176  1.00 382.34 ? 471 TYR A C     1 
ATOM   3165 O O     . TYR A 1 471 ? 95.698  89.455  99.408  1.00 382.34 ? 471 TYR A O     1 
ATOM   3166 C CB    . TYR A 1 471 ? 98.479  89.584  100.061 1.00 382.34 ? 471 TYR A CB    1 
ATOM   3167 C CG    . TYR A 1 471 ? 99.445  89.627  101.222 1.00 382.34 ? 471 TYR A CG    1 
ATOM   3168 C CD1   . TYR A 1 471 ? 99.147  88.989  102.418 1.00 382.34 ? 471 TYR A CD1   1 
ATOM   3169 C CD2   . TYR A 1 471 ? 100.654 90.302  101.123 1.00 382.34 ? 471 TYR A CD2   1 
ATOM   3170 C CE1   . TYR A 1 471 ? 100.026 89.021  103.486 1.00 382.34 ? 471 TYR A CE1   1 
ATOM   3171 C CE2   . TYR A 1 471 ? 101.540 90.340  102.185 1.00 382.34 ? 471 TYR A CE2   1 
ATOM   3172 C CZ    . TYR A 1 471 ? 101.220 89.698  103.363 1.00 382.34 ? 471 TYR A CZ    1 
ATOM   3173 O OH    . TYR A 1 471 ? 102.098 89.734  104.423 1.00 382.34 ? 471 TYR A OH    1 
ATOM   3174 N N     . GLY A 1 472 ? 96.112  87.591  98.232  1.00 399.91 ? 472 GLY A N     1 
ATOM   3175 C CA    . GLY A 1 472 ? 94.790  87.487  97.646  1.00 399.91 ? 472 GLY A CA    1 
ATOM   3176 C C     . GLY A 1 472 ? 94.578  88.059  96.261  1.00 399.91 ? 472 GLY A C     1 
ATOM   3177 O O     . GLY A 1 472 ? 93.425  88.157  95.829  1.00 399.91 ? 472 GLY A O     1 
ATOM   3178 N N     . MET A 1 473 ? 95.636  88.441  95.549  1.00 439.19 ? 473 MET A N     1 
ATOM   3179 C CA    . MET A 1 473 ? 95.464  88.982  94.206  1.00 439.19 ? 473 MET A CA    1 
ATOM   3180 C C     . MET A 1 473 ? 95.027  87.881  93.246  1.00 439.19 ? 473 MET A C     1 
ATOM   3181 O O     . MET A 1 473 ? 95.283  86.696  93.487  1.00 439.19 ? 473 MET A O     1 
ATOM   3182 C CB    . MET A 1 473 ? 96.749  89.648  93.716  1.00 439.19 ? 473 MET A CB    1 
ATOM   3183 C CG    . MET A 1 473 ? 96.650  91.166  93.663  1.00 439.19 ? 473 MET A CG    1 
ATOM   3184 S SD    . MET A 1 473 ? 98.095  91.974  92.952  1.00 439.19 ? 473 MET A SD    1 
ATOM   3185 C CE    . MET A 1 473 ? 99.184  92.020  94.370  1.00 439.19 ? 473 MET A CE    1 
ATOM   3186 N N     . ASN A 1 474 ? 94.366  88.267  92.157  1.00 411.50 ? 474 ASN A N     1 
ATOM   3187 C CA    . ASN A 1 474 ? 94.186  87.325  91.064  1.00 411.50 ? 474 ASN A CA    1 
ATOM   3188 C C     . ASN A 1 474 ? 95.266  87.534  90.005  1.00 411.50 ? 474 ASN A C     1 
ATOM   3189 O O     . ASN A 1 474 ? 96.076  88.460  90.079  1.00 411.50 ? 474 ASN A O     1 
ATOM   3190 C CB    . ASN A 1 474 ? 92.784  87.462  90.463  1.00 411.50 ? 474 ASN A CB    1 
ATOM   3191 C CG    . ASN A 1 474 ? 92.476  88.874  89.978  1.00 411.50 ? 474 ASN A CG    1 
ATOM   3192 O OD1   . ASN A 1 474 ? 93.360  89.605  89.528  1.00 411.50 ? 474 ASN A OD1   1 
ATOM   3193 N ND2   . ASN A 1 474 ? 91.210  89.261  90.070  1.00 411.50 ? 474 ASN A ND2   1 
ATOM   3194 N N     . TYR A 1 475 ? 95.270  86.652  88.999  1.00 393.51 ? 475 TYR A N     1 
ATOM   3195 C CA    . TYR A 1 475 ? 96.371  86.657  88.041  1.00 393.51 ? 475 TYR A CA    1 
ATOM   3196 C C     . TYR A 1 475 ? 96.403  87.926  87.196  1.00 393.51 ? 475 TYR A C     1 
ATOM   3197 O O     . TYR A 1 475 ? 97.487  88.362  86.790  1.00 393.51 ? 475 TYR A O     1 
ATOM   3198 C CB    . TYR A 1 475 ? 96.290  85.419  87.146  1.00 393.51 ? 475 TYR A CB    1 
ATOM   3199 C CG    . TYR A 1 475 ? 95.115  85.410  86.194  1.00 393.51 ? 475 TYR A CG    1 
ATOM   3200 C CD1   . TYR A 1 475 ? 93.858  85.001  86.617  1.00 393.51 ? 475 TYR A CD1   1 
ATOM   3201 C CD2   . TYR A 1 475 ? 95.266  85.799  84.869  1.00 393.51 ? 475 TYR A CD2   1 
ATOM   3202 C CE1   . TYR A 1 475 ? 92.781  84.987  85.752  1.00 393.51 ? 475 TYR A CE1   1 
ATOM   3203 C CE2   . TYR A 1 475 ? 94.195  85.789  83.996  1.00 393.51 ? 475 TYR A CE2   1 
ATOM   3204 C CZ    . TYR A 1 475 ? 92.956  85.382  84.442  1.00 393.51 ? 475 TYR A CZ    1 
ATOM   3205 O OH    . TYR A 1 475 ? 91.886  85.370  83.577  1.00 393.51 ? 475 TYR A OH    1 
ATOM   3206 N N     . VAL A 1 476 ? 95.251  88.555  86.949  1.00 426.83 ? 476 VAL A N     1 
ATOM   3207 C CA    . VAL A 1 476 ? 95.268  89.816  86.216  1.00 426.83 ? 476 VAL A CA    1 
ATOM   3208 C C     . VAL A 1 476 ? 95.932  90.900  87.053  1.00 426.83 ? 476 VAL A C     1 
ATOM   3209 O O     . VAL A 1 476 ? 96.851  91.589  86.596  1.00 426.83 ? 476 VAL A O     1 
ATOM   3210 C CB    . VAL A 1 476 ? 93.841  90.217  85.804  1.00 426.83 ? 476 VAL A CB    1 
ATOM   3211 C CG1   . VAL A 1 476 ? 93.851  91.560  85.088  1.00 426.83 ? 476 VAL A CG1   1 
ATOM   3212 C CG2   . VAL A 1 476 ? 93.220  89.142  84.925  1.00 426.83 ? 476 VAL A CG2   1 
ATOM   3213 N N     . ASN A 1 477 ? 95.467  91.072  88.294  1.00 426.62 ? 477 ASN A N     1 
ATOM   3214 C CA    . ASN A 1 477 ? 96.102  92.017  89.204  1.00 426.62 ? 477 ASN A CA    1 
ATOM   3215 C C     . ASN A 1 477 ? 97.556  91.646  89.462  1.00 426.62 ? 477 ASN A C     1 
ATOM   3216 O O     . ASN A 1 477 ? 98.402  92.531  89.632  1.00 426.62 ? 477 ASN A O     1 
ATOM   3217 C CB    . ASN A 1 477 ? 95.323  92.092  90.515  1.00 426.62 ? 477 ASN A CB    1 
ATOM   3218 C CG    . ASN A 1 477 ? 93.904  92.589  90.322  1.00 426.62 ? 477 ASN A CG    1 
ATOM   3219 O OD1   . ASN A 1 477 ? 93.614  93.322  89.375  1.00 426.62 ? 477 ASN A OD1   1 
ATOM   3220 N ND2   . ASN A 1 477 ? 93.010  92.193  91.221  1.00 426.62 ? 477 ASN A ND2   1 
ATOM   3221 N N     . LEU A 1 478 ? 97.851  90.342  89.509  1.00 418.12 ? 478 LEU A N     1 
ATOM   3222 C CA    . LEU A 1 478 ? 99.220  89.881  89.712  1.00 418.12 ? 478 LEU A CA    1 
ATOM   3223 C C     . LEU A 1 478 ? 100.143 90.342  88.594  1.00 418.12 ? 478 LEU A C     1 
ATOM   3224 O O     . LEU A 1 478 ? 101.254 90.813  88.858  1.00 418.12 ? 478 LEU A O     1 
ATOM   3225 C CB    . LEU A 1 478 ? 99.253  88.358  89.822  1.00 418.12 ? 478 LEU A CB    1 
ATOM   3226 C CG    . LEU A 1 478 ? 100.645 87.747  89.997  1.00 418.12 ? 478 LEU A CG    1 
ATOM   3227 C CD1   . LEU A 1 478 ? 101.329 88.307  91.237  1.00 418.12 ? 478 LEU A CD1   1 
ATOM   3228 C CD2   . LEU A 1 478 ? 100.577 86.229  90.044  1.00 418.12 ? 478 LEU A CD2   1 
ATOM   3229 N N     . LYS A 1 479 ? 99.721  90.170  87.339  1.00 361.41 ? 479 LYS A N     1 
ATOM   3230 C CA    . LYS A 1 479 ? 100.528 90.636  86.215  1.00 361.41 ? 479 LYS A CA    1 
ATOM   3231 C C     . LYS A 1 479 ? 100.870 92.114  86.358  1.00 361.41 ? 479 LYS A C     1 
ATOM   3232 O O     . LYS A 1 479 ? 102.034 92.513  86.218  1.00 361.41 ? 479 LYS A O     1 
ATOM   3233 C CB    . LYS A 1 479 ? 99.793  90.373  84.900  1.00 361.41 ? 479 LYS A CB    1 
ATOM   3234 C CG    . LYS A 1 479 ? 100.453 90.999  83.683  1.00 361.41 ? 479 LYS A CG    1 
ATOM   3235 C CD    . LYS A 1 479 ? 99.652  90.726  82.421  1.00 361.41 ? 479 LYS A CD    1 
ATOM   3236 C CE    . LYS A 1 479 ? 100.243 91.454  81.224  1.00 361.41 ? 479 LYS A CE    1 
ATOM   3237 N NZ    . LYS A 1 479 ? 99.476  91.182  79.976  1.00 361.41 ? 479 LYS A NZ    1 
ATOM   3238 N N     . ASN A 1 480 ? 99.862  92.943  86.644  1.00 400.16 ? 480 ASN A N     1 
ATOM   3239 C CA    . ASN A 1 480 ? 100.088 94.380  86.744  1.00 400.16 ? 480 ASN A CA    1 
ATOM   3240 C C     . ASN A 1 480 ? 101.004 94.721  87.913  1.00 400.16 ? 480 ASN A C     1 
ATOM   3241 O O     . ASN A 1 480 ? 101.938 95.516  87.761  1.00 400.16 ? 480 ASN A O     1 
ATOM   3242 C CB    . ASN A 1 480 ? 98.751  95.109  86.877  1.00 400.16 ? 480 ASN A CB    1 
ATOM   3243 C CG    . ASN A 1 480 ? 97.844  94.879  85.684  1.00 400.16 ? 480 ASN A CG    1 
ATOM   3244 O OD1   . ASN A 1 480 ? 98.312  94.690  84.562  1.00 400.16 ? 480 ASN A OD1   1 
ATOM   3245 N ND2   . ASN A 1 480 ? 96.538  94.891  85.922  1.00 400.16 ? 480 ASN A ND2   1 
ATOM   3246 N N     . TYR A 1 481 ? 100.763 94.121  89.082  1.00 440.44 ? 481 TYR A N     1 
ATOM   3247 C CA    . TYR A 1 481 ? 101.597 94.390  90.250  1.00 440.44 ? 481 TYR A CA    1 
ATOM   3248 C C     . TYR A 1 481 ? 103.043 93.986  89.994  1.00 440.44 ? 481 TYR A C     1 
ATOM   3249 O O     . TYR A 1 481 ? 103.981 94.722  90.329  1.00 440.44 ? 481 TYR A O     1 
ATOM   3250 C CB    . TYR A 1 481 ? 101.037 93.651  91.467  1.00 440.44 ? 481 TYR A CB    1 
ATOM   3251 C CG    . TYR A 1 481 ? 101.927 93.708  92.684  1.00 440.44 ? 481 TYR A CG    1 
ATOM   3252 C CD1   . TYR A 1 481 ? 102.174 94.910  93.330  1.00 440.44 ? 481 TYR A CD1   1 
ATOM   3253 C CD2   . TYR A 1 481 ? 102.527 92.560  93.183  1.00 440.44 ? 481 TYR A CD2   1 
ATOM   3254 C CE1   . TYR A 1 481 ? 102.990 94.968  94.444  1.00 440.44 ? 481 TYR A CE1   1 
ATOM   3255 C CE2   . TYR A 1 481 ? 103.344 92.607  94.295  1.00 440.44 ? 481 TYR A CE2   1 
ATOM   3256 C CZ    . TYR A 1 481 ? 103.573 93.813  94.922  1.00 440.44 ? 481 TYR A CZ    1 
ATOM   3257 O OH    . TYR A 1 481 ? 104.387 93.865  96.030  1.00 440.44 ? 481 TYR A OH    1 
ATOM   3258 N N     . ALA A 1 482 ? 103.236 92.824  89.365  1.00 400.91 ? 482 ALA A N     1 
ATOM   3259 C CA    . ALA A 1 482 ? 104.574 92.324  89.081  1.00 400.91 ? 482 ALA A CA    1 
ATOM   3260 C C     . ALA A 1 482 ? 105.300 93.245  88.118  1.00 400.91 ? 482 ALA A C     1 
ATOM   3261 O O     . ALA A 1 482 ? 106.433 93.664  88.384  1.00 400.91 ? 482 ALA A O     1 
ATOM   3262 C CB    . ALA A 1 482 ? 104.498 90.905  88.519  1.00 400.91 ? 482 ALA A CB    1 
ATOM   3263 N N     . ASN A 1 483 ? 104.672 93.563  86.984  1.00 411.39 ? 483 ASN A N     1 
ATOM   3264 C CA    . ASN A 1 483 ? 105.347 94.399  86.000  1.00 411.39 ? 483 ASN A CA    1 
ATOM   3265 C C     . ASN A 1 483 ? 105.594 95.798  86.554  1.00 411.39 ? 483 ASN A C     1 
ATOM   3266 O O     . ASN A 1 483 ? 106.607 96.428  86.230  1.00 411.39 ? 483 ASN A O     1 
ATOM   3267 C CB    . ASN A 1 483 ? 104.513 94.473  84.721  1.00 411.39 ? 483 ASN A CB    1 
ATOM   3268 C CG    . ASN A 1 483 ? 104.121 93.104  84.198  1.00 411.39 ? 483 ASN A CG    1 
ATOM   3269 O OD1   . ASN A 1 483 ? 104.742 92.096  84.528  1.00 411.39 ? 483 ASN A OD1   1 
ATOM   3270 N ND2   . ASN A 1 483 ? 103.079 93.063  83.376  1.00 411.39 ? 483 ASN A ND2   1 
ATOM   3271 N N     . THR A 1 484 ? 104.680 96.301  87.389  1.00 433.48 ? 484 THR A N     1 
ATOM   3272 C CA    . THR A 1 484 ? 104.802 97.652  87.922  1.00 433.48 ? 484 THR A CA    1 
ATOM   3273 C C     . THR A 1 484 ? 105.929 97.765  88.943  1.00 433.48 ? 484 THR A C     1 
ATOM   3274 O O     . THR A 1 484 ? 106.802 98.630  88.814  1.00 433.48 ? 484 THR A O     1 
ATOM   3275 C CB    . THR A 1 484 ? 103.478 98.092  88.545  1.00 433.48 ? 484 THR A CB    1 
ATOM   3276 O OG1   . THR A 1 484 ? 102.460 98.117  87.537  1.00 433.48 ? 484 THR A OG1   1 
ATOM   3277 C CG2   . THR A 1 484 ? 103.611 99.480  89.150  1.00 433.48 ? 484 THR A CG2   1 
ATOM   3278 N N     . TYR A 1 485 ? 105.934 96.901  89.964  1.00 395.66 ? 485 TYR A N     1 
ATOM   3279 C CA    . TYR A 1 485 ? 106.846 97.061  91.089  1.00 395.66 ? 485 TYR A CA    1 
ATOM   3280 C C     . TYR A 1 485 ? 108.091 96.191  91.012  1.00 395.66 ? 485 TYR A C     1 
ATOM   3281 O O     . TYR A 1 485 ? 109.056 96.464  91.733  1.00 395.66 ? 485 TYR A O     1 
ATOM   3282 C CB    . TYR A 1 485 ? 106.122 96.773  92.414  1.00 395.66 ? 485 TYR A CB    1 
ATOM   3283 C CG    . TYR A 1 485 ? 105.019 97.757  92.744  1.00 395.66 ? 485 TYR A CG    1 
ATOM   3284 C CD1   . TYR A 1 485 ? 103.752 97.626  92.192  1.00 395.66 ? 485 TYR A CD1   1 
ATOM   3285 C CD2   . TYR A 1 485 ? 105.249 98.820  93.609  1.00 395.66 ? 485 TYR A CD2   1 
ATOM   3286 C CE1   . TYR A 1 485 ? 102.744 98.522  92.495  1.00 395.66 ? 485 TYR A CE1   1 
ATOM   3287 C CE2   . TYR A 1 485 ? 104.247 99.721  93.917  1.00 395.66 ? 485 TYR A CE2   1 
ATOM   3288 C CZ    . TYR A 1 485 ? 102.998 99.568  93.357  1.00 395.66 ? 485 TYR A CZ    1 
ATOM   3289 O OH    . TYR A 1 485 ? 101.999 100.465 93.660  1.00 395.66 ? 485 TYR A OH    1 
ATOM   3290 N N     . TYR A 1 486 ? 108.097 95.163  90.169  1.00 389.02 ? 486 TYR A N     1 
ATOM   3291 C CA    . TYR A 1 486 ? 109.245 94.281  90.022  1.00 389.02 ? 486 TYR A CA    1 
ATOM   3292 C C     . TYR A 1 486 ? 109.856 94.362  88.630  1.00 389.02 ? 486 TYR A C     1 
ATOM   3293 O O     . TYR A 1 486 ? 110.940 93.810  88.411  1.00 389.02 ? 486 TYR A O     1 
ATOM   3294 C CB    . TYR A 1 486 ? 108.856 92.829  90.328  1.00 389.02 ? 486 TYR A CB    1 
ATOM   3295 C CG    . TYR A 1 486 ? 108.427 92.589  91.758  1.00 389.02 ? 486 TYR A CG    1 
ATOM   3296 C CD1   . TYR A 1 486 ? 107.156 92.946  92.194  1.00 389.02 ? 486 TYR A CD1   1 
ATOM   3297 C CD2   . TYR A 1 486 ? 109.292 92.003  92.674  1.00 389.02 ? 486 TYR A CD2   1 
ATOM   3298 C CE1   . TYR A 1 486 ? 106.761 92.728  93.499  1.00 389.02 ? 486 TYR A CE1   1 
ATOM   3299 C CE2   . TYR A 1 486 ? 108.904 91.780  93.983  1.00 389.02 ? 486 TYR A CE2   1 
ATOM   3300 C CZ    . TYR A 1 486 ? 107.638 92.143  94.389  1.00 389.02 ? 486 TYR A CZ    1 
ATOM   3301 O OH    . TYR A 1 486 ? 107.247 91.924  95.690  1.00 389.02 ? 486 TYR A OH    1 
ATOM   3302 N N     . GLY A 1 487 ? 109.194 95.041  87.698  1.00 405.67 ? 487 GLY A N     1 
ATOM   3303 C CA    . GLY A 1 487 ? 109.698 95.206  86.346  1.00 405.67 ? 487 GLY A CA    1 
ATOM   3304 C C     . GLY A 1 487 ? 109.932 93.901  85.625  1.00 405.67 ? 487 GLY A C     1 
ATOM   3305 O O     . GLY A 1 487 ? 111.043 93.644  85.149  1.00 405.67 ? 487 GLY A O     1 
ATOM   3306 N N     . LEU A 1 488 ? 108.906 93.063  85.537  1.00 407.97 ? 488 LEU A N     1 
ATOM   3307 C CA    . LEU A 1 488 ? 109.003 91.726  84.975  1.00 407.97 ? 488 LEU A CA    1 
ATOM   3308 C C     . LEU A 1 488 ? 108.220 91.669  83.670  1.00 407.97 ? 488 LEU A C     1 
ATOM   3309 O O     . LEU A 1 488 ? 107.169 92.299  83.531  1.00 407.97 ? 488 LEU A O     1 
ATOM   3310 C CB    . LEU A 1 488 ? 108.490 90.691  85.977  1.00 407.97 ? 488 LEU A CB    1 
ATOM   3311 C CG    . LEU A 1 488 ? 109.334 90.710  87.257  1.00 407.97 ? 488 LEU A CG    1 
ATOM   3312 C CD1   . LEU A 1 488 ? 108.830 89.725  88.294  1.00 407.97 ? 488 LEU A CD1   1 
ATOM   3313 C CD2   . LEU A 1 488 ? 110.802 90.449  86.936  1.00 407.97 ? 488 LEU A CD2   1 
ATOM   3314 N N     . ASN A 1 489 ? 108.753 90.937  82.696  1.00 506.20 ? 489 ASN A N     1 
ATOM   3315 C CA    . ASN A 1 489 ? 108.125 90.810  81.384  1.00 506.20 ? 489 ASN A CA    1 
ATOM   3316 C C     . ASN A 1 489 ? 107.365 89.486  81.309  1.00 506.20 ? 489 ASN A C     1 
ATOM   3317 O O     . ASN A 1 489 ? 107.667 88.618  80.489  1.00 506.20 ? 489 ASN A O     1 
ATOM   3318 C CB    . ASN A 1 489 ? 109.193 90.924  80.277  1.00 506.20 ? 489 ASN A CB    1 
ATOM   3319 C CG    . ASN A 1 489 ? 108.602 90.842  78.882  1.00 506.20 ? 489 ASN A CG    1 
ATOM   3320 O OD1   . ASN A 1 489 ? 107.484 91.296  78.640  1.00 506.20 ? 489 ASN A OD1   1 
ATOM   3321 N ND2   . ASN A 1 489 ? 109.353 90.257  77.955  1.00 506.20 ? 489 ASN A ND2   1 
ATOM   3322 N N     . MET A 1 490 ? 106.377 89.316  82.188  1.00 472.51 ? 490 MET A N     1 
ATOM   3323 C CA    . MET A 1 490 ? 105.522 88.136  82.146  1.00 472.51 ? 490 MET A CA    1 
ATOM   3324 C C     . MET A 1 490 ? 104.301 88.374  81.270  1.00 472.51 ? 490 MET A C     1 
ATOM   3325 O O     . MET A 1 490 ? 103.926 89.524  81.008  1.00 472.51 ? 490 MET A O     1 
ATOM   3326 C CB    . MET A 1 490 ? 105.037 87.751  83.544  1.00 472.51 ? 490 MET A CB    1 
ATOM   3327 C CG    . MET A 1 490 ? 106.096 87.582  84.604  1.00 472.51 ? 490 MET A CG    1 
ATOM   3328 S SD    . MET A 1 490 ? 105.268 87.196  86.158  1.00 472.51 ? 490 MET A SD    1 
ATOM   3329 C CE    . MET A 1 490 ? 106.646 87.153  87.287  1.00 472.51 ? 490 MET A CE    1 
ATOM   3330 N N     . SER A 1 491 ? 103.685 87.282  80.824  1.00 396.89 ? 491 SER A N     1 
ATOM   3331 C CA    . SER A 1 491 ? 102.505 87.312  79.976  1.00 396.89 ? 491 SER A CA    1 
ATOM   3332 C C     . SER A 1 491 ? 101.281 86.941  80.810  1.00 396.89 ? 491 SER A C     1 
ATOM   3333 O O     . SER A 1 491 ? 101.397 86.394  81.912  1.00 396.89 ? 491 SER A O     1 
ATOM   3334 C CB    . SER A 1 491 ? 102.648 86.374  78.776  1.00 396.89 ? 491 SER A CB    1 
ATOM   3335 O OG    . SER A 1 491 ? 102.872 85.040  79.180  1.00 396.89 ? 491 SER A OG    1 
ATOM   3336 N N     . LEU A 1 492 ? 100.095 87.258  80.287  1.00 350.22 ? 492 LEU A N     1 
ATOM   3337 C CA    . LEU A 1 492 ? 98.875  86.939  81.024  1.00 350.22 ? 492 LEU A CA    1 
ATOM   3338 C C     . LEU A 1 492 ? 98.730  85.432  81.213  1.00 350.22 ? 492 LEU A C     1 
ATOM   3339 O O     . LEU A 1 492 ? 98.356  84.965  82.297  1.00 350.22 ? 492 LEU A O     1 
ATOM   3340 C CB    . LEU A 1 492 ? 97.658  87.515  80.303  1.00 350.22 ? 492 LEU A CB    1 
ATOM   3341 C CG    . LEU A 1 492 ? 96.339  87.452  81.073  1.00 350.22 ? 492 LEU A CG    1 
ATOM   3342 C CD1   . LEU A 1 492 ? 96.475  88.149  82.418  1.00 350.22 ? 492 LEU A CD1   1 
ATOM   3343 C CD2   . LEU A 1 492 ? 95.213  88.070  80.261  1.00 350.22 ? 492 LEU A CD2   1 
ATOM   3344 N N     . ASP A 1 493 ? 99.027  84.656  80.165  1.00 339.69 ? 493 ASP A N     1 
ATOM   3345 C CA    . ASP A 1 493 ? 98.959  83.199  80.252  1.00 339.69 ? 493 ASP A CA    1 
ATOM   3346 C C     . ASP A 1 493 ? 99.944  82.658  81.282  1.00 339.69 ? 493 ASP A C     1 
ATOM   3347 O O     . ASP A 1 493 ? 99.642  81.698  82.004  1.00 339.69 ? 493 ASP A O     1 
ATOM   3348 C CB    . ASP A 1 493 ? 99.221  82.580  78.879  1.00 339.69 ? 493 ASP A CB    1 
ATOM   3349 C CG    . ASP A 1 493 ? 98.043  82.732  77.939  1.00 339.69 ? 493 ASP A CG    1 
ATOM   3350 O OD1   . ASP A 1 493 ? 96.893  82.764  78.424  1.00 339.69 ? 493 ASP A OD1   1 
ATOM   3351 O OD2   . ASP A 1 493 ? 98.268  82.821  76.713  1.00 339.69 ? 493 ASP A OD2   1 
ATOM   3352 N N     . GLN A 1 494 ? 101.096 83.315  81.420  1.00 348.76 ? 494 GLN A N     1 
ATOM   3353 C CA    . GLN A 1 494 ? 102.057 82.900  82.432  1.00 348.76 ? 494 GLN A CA    1 
ATOM   3354 C C     . GLN A 1 494 ? 101.525 83.159  83.832  1.00 348.76 ? 494 GLN A C     1 
ATOM   3355 O O     . GLN A 1 494 ? 101.552 82.254  84.669  1.00 348.76 ? 494 GLN A O     1 
ATOM   3356 C CB    . GLN A 1 494 ? 103.403 83.595  82.232  1.00 348.76 ? 494 GLN A CB    1 
ATOM   3357 C CG    . GLN A 1 494 ? 104.194 83.089  81.040  1.00 348.76 ? 494 GLN A CG    1 
ATOM   3358 C CD    . GLN A 1 494 ? 105.432 83.919  80.772  1.00 348.76 ? 494 GLN A CD    1 
ATOM   3359 O OE1   . GLN A 1 494 ? 105.363 85.144  80.681  1.00 348.76 ? 494 GLN A OE1   1 
ATOM   3360 N NE2   . GLN A 1 494 ? 106.573 83.254  80.643  1.00 348.76 ? 494 GLN A NE2   1 
ATOM   3361 N N     . CYS A 1 495 ? 101.155 84.399  84.144  1.00 348.09 ? 495 CYS A N     1 
ATOM   3362 C CA    . CYS A 1 495 ? 100.627 84.676  85.476  1.00 348.09 ? 495 CYS A CA    1 
ATOM   3363 C C     . CYS A 1 495 ? 99.397  83.823  85.787  1.00 348.09 ? 495 CYS A C     1 
ATOM   3364 O O     . CYS A 1 495 ? 99.161  83.469  86.946  1.00 348.09 ? 495 CYS A O     1 
ATOM   3365 C CB    . CYS A 1 495 ? 100.292 86.161  85.606  1.00 348.09 ? 495 CYS A CB    1 
ATOM   3366 S SG    . CYS A 1 495 ? 101.731 87.251  85.630  1.00 348.09 ? 495 CYS A SG    1 
ATOM   3367 N N     . LEU A 1 496 ? 98.629  83.434  84.762  1.00 335.52 ? 496 LEU A N     1 
ATOM   3368 C CA    . LEU A 1 496 ? 97.510  82.517  84.985  1.00 335.52 ? 496 LEU A CA    1 
ATOM   3369 C C     . LEU A 1 496 ? 97.992  81.111  85.326  1.00 335.52 ? 496 LEU A C     1 
ATOM   3370 O O     . LEU A 1 496 ? 97.414  80.429  86.187  1.00 335.52 ? 496 LEU A O     1 
ATOM   3371 C CB    . LEU A 1 496 ? 96.603  82.493  83.754  1.00 335.52 ? 496 LEU A CB    1 
ATOM   3372 C CG    . LEU A 1 496 ? 95.422  81.524  83.814  1.00 335.52 ? 496 LEU A CG    1 
ATOM   3373 C CD1   . LEU A 1 496 ? 94.537  81.831  85.011  1.00 335.52 ? 496 LEU A CD1   1 
ATOM   3374 C CD2   . LEU A 1 496 ? 94.620  81.574  82.523  1.00 335.52 ? 496 LEU A CD2   1 
ATOM   3375 N N     . TYR A 1 497 ? 99.100  80.687  84.714  1.00 319.84 ? 497 TYR A N     1 
ATOM   3376 C CA    . TYR A 1 497 ? 99.696  79.405  85.080  1.00 319.84 ? 497 TYR A CA    1 
ATOM   3377 C C     . TYR A 1 497 ? 100.246 79.463  86.496  1.00 319.84 ? 497 TYR A C     1 
ATOM   3378 O O     . TYR A 1 497 ? 100.114 78.509  87.269  1.00 319.84 ? 497 TYR A O     1 
ATOM   3379 C CB    . TYR A 1 497 ? 100.794 79.025  84.089  1.00 319.84 ? 497 TYR A CB    1 
ATOM   3380 C CG    . TYR A 1 497 ? 101.663 77.884  84.568  1.00 319.84 ? 497 TYR A CG    1 
ATOM   3381 C CD1   . TYR A 1 497 ? 101.216 76.571  84.506  1.00 319.84 ? 497 TYR A CD1   1 
ATOM   3382 C CD2   . TYR A 1 497 ? 102.930 78.121  85.086  1.00 319.84 ? 497 TYR A CD2   1 
ATOM   3383 C CE1   . TYR A 1 497 ? 102.007 75.527  84.945  1.00 319.84 ? 497 TYR A CE1   1 
ATOM   3384 C CE2   . TYR A 1 497 ? 103.727 77.083  85.529  1.00 319.84 ? 497 TYR A CE2   1 
ATOM   3385 C CZ    . TYR A 1 497 ? 103.262 75.788  85.456  1.00 319.84 ? 497 TYR A CZ    1 
ATOM   3386 O OH    . TYR A 1 497 ? 104.052 74.752  85.896  1.00 319.84 ? 497 TYR A OH    1 
ATOM   3387 N N     . PHE A 1 498 ? 100.907 80.569  86.829  1.00 368.44 ? 498 PHE A N     1 
ATOM   3388 C CA    . PHE A 1 498 ? 101.389 80.786  88.187  1.00 368.44 ? 498 PHE A CA    1 
ATOM   3389 C C     . PHE A 1 498 ? 100.239 80.681  89.174  1.00 368.44 ? 498 PHE A C     1 
ATOM   3390 O O     . PHE A 1 498 ? 100.367 80.040  90.219  1.00 368.44 ? 498 PHE A O     1 
ATOM   3391 C CB    . PHE A 1 498 ? 102.078 82.146  88.287  1.00 368.44 ? 498 PHE A CB    1 
ATOM   3392 C CG    . PHE A 1 498 ? 103.275 82.292  87.386  1.00 368.44 ? 498 PHE A CG    1 
ATOM   3393 C CD1   . PHE A 1 498 ? 103.868 81.180  86.806  1.00 368.44 ? 498 PHE A CD1   1 
ATOM   3394 C CD2   . PHE A 1 498 ? 103.797 83.543  87.105  1.00 368.44 ? 498 PHE A CD2   1 
ATOM   3395 C CE1   . PHE A 1 498 ? 104.965 81.314  85.975  1.00 368.44 ? 498 PHE A CE1   1 
ATOM   3396 C CE2   . PHE A 1 498 ? 104.892 83.682  86.274  1.00 368.44 ? 498 PHE A CE2   1 
ATOM   3397 C CZ    . PHE A 1 498 ? 105.476 82.566  85.709  1.00 368.44 ? 498 PHE A CZ    1 
ATOM   3398 N N     . TYR A 1 499 ? 99.113  81.322  88.861  1.00 340.31 ? 499 TYR A N     1 
ATOM   3399 C CA    . TYR A 1 499 ? 97.950  81.312  89.742  1.00 340.31 ? 499 TYR A CA    1 
ATOM   3400 C C     . TYR A 1 499 ? 97.462  79.885  89.970  1.00 340.31 ? 499 TYR A C     1 
ATOM   3401 O O     . TYR A 1 499 ? 97.265  79.449  91.116  1.00 340.31 ? 499 TYR A O     1 
ATOM   3402 C CB    . TYR A 1 499 ? 96.849  82.177  89.122  1.00 340.31 ? 499 TYR A CB    1 
ATOM   3403 C CG    . TYR A 1 499 ? 95.563  82.280  89.913  1.00 340.31 ? 499 TYR A CG    1 
ATOM   3404 C CD1   . TYR A 1 499 ? 94.560  81.329  89.777  1.00 340.31 ? 499 TYR A CD1   1 
ATOM   3405 C CD2   . TYR A 1 499 ? 95.335  83.353  90.764  1.00 340.31 ? 499 TYR A CD2   1 
ATOM   3406 C CE1   . TYR A 1 499 ? 93.381  81.427  90.488  1.00 340.31 ? 499 TYR A CE1   1 
ATOM   3407 C CE2   . TYR A 1 499 ? 94.155  83.463  91.475  1.00 340.31 ? 499 TYR A CE2   1 
ATOM   3408 C CZ    . TYR A 1 499 ? 93.183  82.496  91.334  1.00 340.31 ? 499 TYR A CZ    1 
ATOM   3409 O OH    . TYR A 1 499 ? 92.008  82.599  92.043  1.00 340.31 ? 499 TYR A OH    1 
ATOM   3410 N N     . ASN A 1 500 ? 97.267  79.139  88.877  1.00 313.67 ? 500 ASN A N     1 
ATOM   3411 C CA    . ASN A 1 500 ? 96.727  77.790  89.001  1.00 313.67 ? 500 ASN A CA    1 
ATOM   3412 C C     . ASN A 1 500 ? 97.704  76.860  89.715  1.00 313.67 ? 500 ASN A C     1 
ATOM   3413 O O     . ASN A 1 500 ? 97.293  76.063  90.563  1.00 313.67 ? 500 ASN A O     1 
ATOM   3414 C CB    . ASN A 1 500 ? 96.375  77.239  87.621  1.00 313.67 ? 500 ASN A CB    1 
ATOM   3415 C CG    . ASN A 1 500 ? 95.191  77.950  86.995  1.00 313.67 ? 500 ASN A CG    1 
ATOM   3416 O OD1   . ASN A 1 500 ? 94.312  78.453  87.696  1.00 313.67 ? 500 ASN A OD1   1 
ATOM   3417 N ND2   . ASN A 1 500 ? 95.164  77.999  85.669  1.00 313.67 ? 500 ASN A ND2   1 
ATOM   3418 N N     . SER A 1 501 ? 99.006  76.992  89.440  1.00 321.73 ? 501 SER A N     1 
ATOM   3419 C CA    . SER A 1 501 ? 99.994  76.150  90.108  1.00 321.73 ? 501 SER A CA    1 
ATOM   3420 C C     . SER A 1 501 ? 100.074 76.496  91.587  1.00 321.73 ? 501 SER A C     1 
ATOM   3421 O O     . SER A 1 501 ? 100.152 75.606  92.446  1.00 321.73 ? 501 SER A O     1 
ATOM   3422 C CB    . SER A 1 501 ? 101.359 76.307  89.440  1.00 321.73 ? 501 SER A CB    1 
ATOM   3423 O OG    . SER A 1 501 ? 102.360 75.595  90.149  1.00 321.73 ? 501 SER A OG    1 
ATOM   3424 N N     . LYS A 1 507 ? 99.190  72.842  101.302 1.00 329.75 ? 507 LYS A N     1 
ATOM   3425 C CA    . LYS A 1 507 ? 97.818  72.436  101.574 1.00 329.75 ? 507 LYS A CA    1 
ATOM   3426 C C     . LYS A 1 507 ? 97.223  73.315  102.667 1.00 329.75 ? 507 LYS A C     1 
ATOM   3427 O O     . LYS A 1 507 ? 96.022  73.580  102.691 1.00 329.75 ? 507 LYS A O     1 
ATOM   3428 C CB    . LYS A 1 507 ? 97.771  70.965  101.988 1.00 329.75 ? 507 LYS A CB    1 
ATOM   3429 C CG    . LYS A 1 507 ? 98.199  70.003  100.894 1.00 329.75 ? 507 LYS A CG    1 
ATOM   3430 C CD    . LYS A 1 507 ? 98.136  68.562  101.369 1.00 329.75 ? 507 LYS A CD    1 
ATOM   3431 C CE    . LYS A 1 507 ? 98.579  67.603  100.278 1.00 329.75 ? 507 LYS A CE    1 
ATOM   3432 N NZ    . LYS A 1 507 ? 98.538  66.186  100.735 1.00 329.75 ? 507 LYS A NZ    1 
ATOM   3433 N N     . GLY A 1 508 ? 98.094  73.759  103.574 1.00 299.30 ? 508 GLY A N     1 
ATOM   3434 C CA    . GLY A 1 508 ? 97.666  74.666  104.625 1.00 299.30 ? 508 GLY A CA    1 
ATOM   3435 C C     . GLY A 1 508 ? 97.189  75.997  104.079 1.00 299.30 ? 508 GLY A C     1 
ATOM   3436 O O     . GLY A 1 508 ? 96.174  76.536  104.528 1.00 299.30 ? 508 GLY A O     1 
ATOM   3437 N N     . ILE A 1 509 ? 97.927  76.554  103.117 1.00 289.04 ? 509 ILE A N     1 
ATOM   3438 C CA    . ILE A 1 509 ? 97.531  77.824  102.522 1.00 289.04 ? 509 ILE A CA    1 
ATOM   3439 C C     . ILE A 1 509 ? 96.215  77.667  101.777 1.00 289.04 ? 509 ILE A C     1 
ATOM   3440 O O     . ILE A 1 509 ? 95.342  78.537  101.851 1.00 289.04 ? 509 ILE A O     1 
ATOM   3441 C CB    . ILE A 1 509 ? 98.645  78.363  101.608 1.00 289.04 ? 509 ILE A CB    1 
ATOM   3442 C CG1   . ILE A 1 509 ? 99.942  78.534  102.397 1.00 289.04 ? 509 ILE A CG1   1 
ATOM   3443 C CG2   . ILE A 1 509 ? 98.226  79.682  100.978 1.00 289.04 ? 509 ILE A CG2   1 
ATOM   3444 C CD1   . ILE A 1 509 ? 99.793  79.396  103.632 1.00 289.04 ? 509 ILE A CD1   1 
ATOM   3445 N N     . TYR A 1 510 ? 96.069  76.588  101.005 1.00 316.77 ? 510 TYR A N     1 
ATOM   3446 C CA    . TYR A 1 510 ? 94.816  76.351  100.293 1.00 316.77 ? 510 TYR A CA    1 
ATOM   3447 C C     . TYR A 1 510 ? 93.646  76.302  101.266 1.00 316.77 ? 510 TYR A C     1 
ATOM   3448 O O     . TYR A 1 510 ? 92.612  76.944  101.049 1.00 316.77 ? 510 TYR A O     1 
ATOM   3449 C CB    . TYR A 1 510 ? 94.900  75.046  99.501  1.00 316.77 ? 510 TYR A CB    1 
ATOM   3450 C CG    . TYR A 1 510 ? 93.663  74.734  98.694  1.00 316.77 ? 510 TYR A CG    1 
ATOM   3451 C CD1   . TYR A 1 510 ? 93.311  75.514  97.602  1.00 316.77 ? 510 TYR A CD1   1 
ATOM   3452 C CD2   . TYR A 1 510 ? 92.853  73.654  99.018  1.00 316.77 ? 510 TYR A CD2   1 
ATOM   3453 C CE1   . TYR A 1 510 ? 92.182  75.231  96.857  1.00 316.77 ? 510 TYR A CE1   1 
ATOM   3454 C CE2   . TYR A 1 510 ? 91.723  73.362  98.281  1.00 316.77 ? 510 TYR A CE2   1 
ATOM   3455 C CZ    . TYR A 1 510 ? 91.393  74.155  97.202  1.00 316.77 ? 510 TYR A CZ    1 
ATOM   3456 O OH    . TYR A 1 510 ? 90.267  73.868  96.463  1.00 316.77 ? 510 TYR A OH    1 
ATOM   3457 N N     . LYS A 1 511 ? 93.808  75.556  102.361 1.00 337.74 ? 511 LYS A N     1 
ATOM   3458 C CA    . LYS A 1 511 ? 92.747  75.430  103.354 1.00 337.74 ? 511 LYS A CA    1 
ATOM   3459 C C     . LYS A 1 511 ? 92.440  76.767  104.014 1.00 337.74 ? 511 LYS A C     1 
ATOM   3460 O O     . LYS A 1 511 ? 91.273  77.123  104.200 1.00 337.74 ? 511 LYS A O     1 
ATOM   3461 C CB    . LYS A 1 511 ? 93.145  74.389  104.401 1.00 337.74 ? 511 LYS A CB    1 
ATOM   3462 C CG    . LYS A 1 511 ? 92.152  74.218  105.535 1.00 337.74 ? 511 LYS A CG    1 
ATOM   3463 C CD    . LYS A 1 511 ? 92.551  73.057  106.431 1.00 337.74 ? 511 LYS A CD    1 
ATOM   3464 C CE    . LYS A 1 511 ? 91.714  73.017  107.698 1.00 337.74 ? 511 LYS A CE    1 
ATOM   3465 N NZ    . LYS A 1 511 ? 92.141  71.924  108.613 1.00 337.74 ? 511 LYS A NZ    1 
ATOM   3466 N N     . TRP A 1 512 ? 93.477  77.526  104.373 1.00 330.67 ? 512 TRP A N     1 
ATOM   3467 C CA    . TRP A 1 512 ? 93.261  78.809  105.035 1.00 330.67 ? 512 TRP A CA    1 
ATOM   3468 C C     . TRP A 1 512 ? 92.578  79.801  104.103 1.00 330.67 ? 512 TRP A C     1 
ATOM   3469 O O     . TRP A 1 512 ? 91.654  80.519  104.505 1.00 330.67 ? 512 TRP A O     1 
ATOM   3470 C CB    . TRP A 1 512 ? 94.591  79.366  105.537 1.00 330.67 ? 512 TRP A CB    1 
ATOM   3471 C CG    . TRP A 1 512 ? 94.476  80.719  106.159 1.00 330.67 ? 512 TRP A CG    1 
ATOM   3472 C CD1   . TRP A 1 512 ? 93.663  81.076  107.194 1.00 330.67 ? 512 TRP A CD1   1 
ATOM   3473 C CD2   . TRP A 1 512 ? 95.207  81.896  105.798 1.00 330.67 ? 512 TRP A CD2   1 
ATOM   3474 N NE1   . TRP A 1 512 ? 93.837  82.405  107.496 1.00 330.67 ? 512 TRP A NE1   1 
ATOM   3475 C CE2   . TRP A 1 512 ? 94.781  82.930  106.654 1.00 330.67 ? 512 TRP A CE2   1 
ATOM   3476 C CE3   . TRP A 1 512 ? 96.177  82.176  104.831 1.00 330.67 ? 512 TRP A CE3   1 
ATOM   3477 C CZ2   . TRP A 1 512 ? 95.293  84.223  106.572 1.00 330.67 ? 512 TRP A CZ2   1 
ATOM   3478 C CZ3   . TRP A 1 512 ? 96.686  83.459  104.753 1.00 330.67 ? 512 TRP A CZ3   1 
ATOM   3479 C CH2   . TRP A 1 512 ? 96.245  84.466  105.622 1.00 330.67 ? 512 TRP A CH2   1 
ATOM   3480 N N     . HIS A 1 513 ? 93.026  79.853  102.849 1.00 295.78 ? 513 HIS A N     1 
ATOM   3481 C CA    . HIS A 1 513 ? 92.394  80.723  101.867 1.00 295.78 ? 513 HIS A CA    1 
ATOM   3482 C C     . HIS A 1 513 ? 90.938  80.334  101.667 1.00 295.78 ? 513 HIS A C     1 
ATOM   3483 O O     . HIS A 1 513 ? 90.063  81.201  101.568 1.00 295.78 ? 513 HIS A O     1 
ATOM   3484 C CB    . HIS A 1 513 ? 93.159  80.656  100.546 1.00 295.78 ? 513 HIS A CB    1 
ATOM   3485 C CG    . HIS A 1 513 ? 94.451  81.409  100.565 1.00 295.78 ? 513 HIS A CG    1 
ATOM   3486 N ND1   . HIS A 1 513 ? 95.111  81.784  99.416  1.00 295.78 ? 513 HIS A ND1   1 
ATOM   3487 C CD2   . HIS A 1 513 ? 95.208  81.852  101.595 1.00 295.78 ? 513 HIS A CD2   1 
ATOM   3488 C CE1   . HIS A 1 513 ? 96.219  82.429  99.737  1.00 295.78 ? 513 HIS A CE1   1 
ATOM   3489 N NE2   . HIS A 1 513 ? 96.302  82.483  101.054 1.00 295.78 ? 513 HIS A NE2   1 
ATOM   3490 N N     . ASN A 1 514 ? 90.663  79.033  101.567 1.00 349.44 ? 514 ASN A N     1 
ATOM   3491 C CA    . ASN A 1 514 ? 89.286  78.597  101.381 1.00 349.44 ? 514 ASN A CA    1 
ATOM   3492 C C     . ASN A 1 514 ? 88.433  78.950  102.592 1.00 349.44 ? 514 ASN A C     1 
ATOM   3493 O O     . ASN A 1 514 ? 87.272  79.338  102.446 1.00 349.44 ? 514 ASN A O     1 
ATOM   3494 C CB    . ASN A 1 514 ? 89.245  77.094  101.117 1.00 349.44 ? 514 ASN A CB    1 
ATOM   3495 C CG    . ASN A 1 514 ? 89.462  76.752  99.659  1.00 349.44 ? 514 ASN A CG    1 
ATOM   3496 O OD1   . ASN A 1 514 ? 89.578  77.638  98.812  1.00 349.44 ? 514 ASN A OD1   1 
ATOM   3497 N ND2   . ASN A 1 514 ? 89.515  75.462  99.356  1.00 349.44 ? 514 ASN A ND2   1 
ATOM   3498 N N     . GLN A 1 515 ? 88.995  78.825  103.799 1.00 353.75 ? 515 GLN A N     1 
ATOM   3499 C CA    . GLN A 1 515 ? 88.269  79.217  105.002 1.00 353.75 ? 515 GLN A CA    1 
ATOM   3500 C C     . GLN A 1 515 ? 87.945  80.705  104.990 1.00 353.75 ? 515 GLN A C     1 
ATOM   3501 O O     . GLN A 1 515 ? 86.833  81.116  105.346 1.00 353.75 ? 515 GLN A O     1 
ATOM   3502 C CB    . GLN A 1 515 ? 89.083  78.862  106.247 1.00 353.75 ? 515 GLN A CB    1 
ATOM   3503 C CG    . GLN A 1 515 ? 89.195  77.376  106.527 1.00 353.75 ? 515 GLN A CG    1 
ATOM   3504 C CD    . GLN A 1 515 ? 90.156  77.078  107.659 1.00 353.75 ? 515 GLN A CD    1 
ATOM   3505 O OE1   . GLN A 1 515 ? 90.944  77.934  108.063 1.00 353.75 ? 515 GLN A OE1   1 
ATOM   3506 N NE2   . GLN A 1 515 ? 90.097  75.859  108.180 1.00 353.75 ? 515 GLN A NE2   1 
ATOM   3507 N N     . VAL A 1 516 ? 88.904  81.526  104.555 1.00 332.87 ? 516 VAL A N     1 
ATOM   3508 C CA    . VAL A 1 516 ? 88.666  82.964  104.516 1.00 332.87 ? 516 VAL A CA    1 
ATOM   3509 C C     . VAL A 1 516 ? 87.603  83.292  103.480 1.00 332.87 ? 516 VAL A C     1 
ATOM   3510 O O     . VAL A 1 516 ? 86.712  84.115  103.718 1.00 332.87 ? 516 VAL A O     1 
ATOM   3511 C CB    . VAL A 1 516 ? 89.979  83.720  104.245 1.00 332.87 ? 516 VAL A CB    1 
ATOM   3512 C CG1   . VAL A 1 516 ? 89.709  85.202  104.034 1.00 332.87 ? 516 VAL A CG1   1 
ATOM   3513 C CG2   . VAL A 1 516 ? 90.955  83.517  105.392 1.00 332.87 ? 516 VAL A CG2   1 
ATOM   3514 N N     . LYS A 1 517 ? 87.686  82.656  102.309 1.00 338.82 ? 517 LYS A N     1 
ATOM   3515 C CA    . LYS A 1 517 ? 86.689  82.881  101.272 1.00 338.82 ? 517 LYS A CA    1 
ATOM   3516 C C     . LYS A 1 517 ? 85.301  82.475  101.751 1.00 338.82 ? 517 LYS A C     1 
ATOM   3517 O O     . LYS A 1 517 ? 84.324  83.194  101.521 1.00 338.82 ? 517 LYS A O     1 
ATOM   3518 C CB    . LYS A 1 517 ? 87.078  82.111  100.010 1.00 338.82 ? 517 LYS A CB    1 
ATOM   3519 C CG    . LYS A 1 517 ? 87.969  82.897  99.063  1.00 338.82 ? 517 LYS A CG    1 
ATOM   3520 C CD    . LYS A 1 517 ? 88.266  82.111  97.799  1.00 338.82 ? 517 LYS A CD    1 
ATOM   3521 C CE    . LYS A 1 517 ? 89.295  82.824  96.937  1.00 338.82 ? 517 LYS A CE    1 
ATOM   3522 N NZ    . LYS A 1 517 ? 89.859  81.928  95.891  1.00 338.82 ? 517 LYS A NZ    1 
ATOM   3523 N N     . GLN A 1 518 ? 85.192  81.310  102.396 1.00 464.20 ? 518 GLN A N     1 
ATOM   3524 C CA    . GLN A 1 518 ? 83.896  80.792  102.816 1.00 464.20 ? 518 GLN A CA    1 
ATOM   3525 C C     . GLN A 1 518 ? 83.271  81.633  103.922 1.00 464.20 ? 518 GLN A C     1 
ATOM   3526 O O     . GLN A 1 518 ? 82.091  81.992  103.840 1.00 464.20 ? 518 GLN A O     1 
ATOM   3527 C CB    . GLN A 1 518 ? 84.035  79.341  103.281 1.00 464.20 ? 518 GLN A CB    1 
ATOM   3528 C CG    . GLN A 1 518 ? 84.299  78.343  102.167 1.00 464.20 ? 518 GLN A CG    1 
ATOM   3529 C CD    . GLN A 1 518 ? 84.322  76.911  102.667 1.00 464.20 ? 518 GLN A CD    1 
ATOM   3530 O OE1   . GLN A 1 518 ? 84.116  76.651  103.853 1.00 464.20 ? 518 GLN A OE1   1 
ATOM   3531 N NE2   . GLN A 1 518 ? 84.575  75.971  101.762 1.00 464.20 ? 518 GLN A NE2   1 
ATOM   3532 N N     . LYS A 1 519 ? 84.045  81.952  104.965 1.00 459.96 ? 519 LYS A N     1 
ATOM   3533 C CA    . LYS A 1 519 ? 83.470  82.639  106.116 1.00 459.96 ? 519 LYS A CA    1 
ATOM   3534 C C     . LYS A 1 519 ? 83.055  84.066  105.778 1.00 459.96 ? 519 LYS A C     1 
ATOM   3535 O O     . LYS A 1 519 ? 82.065  84.570  106.320 1.00 459.96 ? 519 LYS A O     1 
ATOM   3536 C CB    . LYS A 1 519 ? 84.468  82.639  107.274 1.00 459.96 ? 519 LYS A CB    1 
ATOM   3537 C CG    . LYS A 1 519 ? 84.794  81.258  107.815 1.00 459.96 ? 519 LYS A CG    1 
ATOM   3538 C CD    . LYS A 1 519 ? 85.995  81.307  108.744 1.00 459.96 ? 519 LYS A CD    1 
ATOM   3539 C CE    . LYS A 1 519 ? 85.969  80.166  109.745 1.00 459.96 ? 519 LYS A CE    1 
ATOM   3540 N NZ    . LYS A 1 519 ? 87.167  80.183  110.631 1.00 459.96 ? 519 LYS A NZ    1 
ATOM   3541 N N     . ARG A 1 520 ? 83.785  84.714  104.868 1.00 504.94 ? 520 ARG A N     1 
ATOM   3542 C CA    . ARG A 1 520 ? 83.540  86.112  104.497 1.00 504.94 ? 520 ARG A CA    1 
ATOM   3543 C C     . ARG A 1 520 ? 83.390  86.984  105.742 1.00 504.94 ? 520 ARG A C     1 
ATOM   3544 O O     . ARG A 1 520 ? 82.524  87.858  105.815 1.00 504.94 ? 520 ARG A O     1 
ATOM   3545 C CB    . ARG A 1 520 ? 82.316  86.239  103.591 1.00 504.94 ? 520 ARG A CB    1 
ATOM   3546 C CG    . ARG A 1 520 ? 82.395  85.404  102.328 1.00 504.94 ? 520 ARG A CG    1 
ATOM   3547 C CD    . ARG A 1 520 ? 81.191  85.612  101.425 1.00 504.94 ? 520 ARG A CD    1 
ATOM   3548 N NE    . ARG A 1 520 ? 81.015  87.014  101.063 1.00 504.94 ? 520 ARG A NE    1 
ATOM   3549 C CZ    . ARG A 1 520 ? 81.741  87.646  100.150 1.00 504.94 ? 520 ARG A CZ    1 
ATOM   3550 N NH1   . ARG A 1 520 ? 81.500  88.932  99.908  1.00 504.94 ? 520 ARG A NH1   1 
ATOM   3551 N NH2   . ARG A 1 520 ? 82.691  87.027  99.471  1.00 504.94 ? 520 ARG A NH2   1 
ATOM   3552 N N     . ALA A 1 521 ? 84.245  86.743  106.731 1.00 536.24 ? 521 ALA A N     1 
ATOM   3553 C CA    . ALA A 1 521 ? 84.128  87.437  108.003 1.00 536.24 ? 521 ALA A CA    1 
ATOM   3554 C C     . ALA A 1 521 ? 84.616  88.877  107.888 1.00 536.24 ? 521 ALA A C     1 
ATOM   3555 O O     . ALA A 1 521 ? 85.349  89.245  106.965 1.00 536.24 ? 521 ALA A O     1 
ATOM   3556 C CB    . ALA A 1 521 ? 84.914  86.703  109.089 1.00 536.24 ? 521 ALA A CB    1 
ATOM   3557 N N     . LEU A 1 522 ? 84.194  89.700  108.849 1.00 575.68 ? 522 LEU A N     1 
ATOM   3558 C CA    . LEU A 1 522 ? 84.616  91.092  108.898 1.00 575.68 ? 522 LEU A CA    1 
ATOM   3559 C C     . LEU A 1 522 ? 85.557  91.385  110.055 1.00 575.68 ? 522 LEU A C     1 
ATOM   3560 O O     . LEU A 1 522 ? 86.263  92.399  110.018 1.00 575.68 ? 522 LEU A O     1 
ATOM   3561 C CB    . LEU A 1 522 ? 83.396  92.014  109.001 1.00 575.68 ? 522 LEU A CB    1 
ATOM   3562 C CG    . LEU A 1 522 ? 82.380  91.922  107.863 1.00 575.68 ? 522 LEU A CG    1 
ATOM   3563 C CD1   . LEU A 1 522 ? 81.206  92.856  108.116 1.00 575.68 ? 522 LEU A CD1   1 
ATOM   3564 C CD2   . LEU A 1 522 ? 83.041  92.235  106.534 1.00 575.68 ? 522 LEU A CD2   1 
ATOM   3565 N N     . GLN A 1 523 ? 85.588  90.526  111.069 1.00 445.66 ? 523 GLN A N     1 
ATOM   3566 C CA    . GLN A 1 523 ? 86.409  90.725  112.255 1.00 445.66 ? 523 GLN A CA    1 
ATOM   3567 C C     . GLN A 1 523 ? 87.584  89.760  112.219 1.00 445.66 ? 523 GLN A C     1 
ATOM   3568 O O     . GLN A 1 523 ? 87.392  88.547  112.093 1.00 445.66 ? 523 GLN A O     1 
ATOM   3569 C CB    . GLN A 1 523 ? 85.590  90.516  113.530 1.00 445.66 ? 523 GLN A CB    1 
ATOM   3570 C CG    . GLN A 1 523 ? 86.344  90.845  114.807 1.00 445.66 ? 523 GLN A CG    1 
ATOM   3571 C CD    . GLN A 1 523 ? 85.421  91.261  115.935 1.00 445.66 ? 523 GLN A CD    1 
ATOM   3572 O OE1   . GLN A 1 523 ? 84.200  91.261  115.785 1.00 445.66 ? 523 GLN A OE1   1 
ATOM   3573 N NE2   . GLN A 1 523 ? 86.004  91.618  117.072 1.00 445.66 ? 523 GLN A NE2   1 
ATOM   3574 N N     . TYR A 1 524 ? 88.794  90.300  112.329 1.00 427.57 ? 524 TYR A N     1 
ATOM   3575 C CA    . TYR A 1 524 ? 89.993  89.474  112.320 1.00 427.57 ? 524 TYR A CA    1 
ATOM   3576 C C     . TYR A 1 524 ? 90.904  89.885  113.466 1.00 427.57 ? 524 TYR A C     1 
ATOM   3577 O O     . TYR A 1 524 ? 90.819  91.000  113.985 1.00 427.57 ? 524 TYR A O     1 
ATOM   3578 C CB    . TYR A 1 524 ? 90.730  89.555  110.975 1.00 427.57 ? 524 TYR A CB    1 
ATOM   3579 C CG    . TYR A 1 524 ? 89.898  89.065  109.810 1.00 427.57 ? 524 TYR A CG    1 
ATOM   3580 C CD1   . TYR A 1 524 ? 88.996  89.905  109.170 1.00 427.57 ? 524 TYR A CD1   1 
ATOM   3581 C CD2   . TYR A 1 524 ? 90.000  87.754  109.364 1.00 427.57 ? 524 TYR A CD2   1 
ATOM   3582 C CE1   . TYR A 1 524 ? 88.230  89.457  108.112 1.00 427.57 ? 524 TYR A CE1   1 
ATOM   3583 C CE2   . TYR A 1 524 ? 89.237  87.296  108.308 1.00 427.57 ? 524 TYR A CE2   1 
ATOM   3584 C CZ    . TYR A 1 524 ? 88.352  88.150  107.687 1.00 427.57 ? 524 TYR A CZ    1 
ATOM   3585 O OH    . TYR A 1 524 ? 87.591  87.699  106.634 1.00 427.57 ? 524 TYR A OH    1 
ATOM   3586 N N     . SER A 1 525 ? 91.775  88.961  113.868 1.00 293.68 ? 525 SER A N     1 
ATOM   3587 C CA    . SER A 1 525 ? 92.669  89.205  114.989 1.00 293.68 ? 525 SER A CA    1 
ATOM   3588 C C     . SER A 1 525 ? 94.053  88.643  114.701 1.00 293.68 ? 525 SER A C     1 
ATOM   3589 O O     . SER A 1 525 ? 94.226  87.779  113.836 1.00 293.68 ? 525 SER A O     1 
ATOM   3590 C CB    . SER A 1 525 ? 92.120  88.594  116.284 1.00 293.68 ? 525 SER A CB    1 
ATOM   3591 O OG    . SER A 1 525 ? 91.731  87.247  116.086 1.00 293.68 ? 525 SER A OG    1 
ATOM   3592 N N     . THR A 1 526 ? 95.036  89.149  115.442 1.00 275.57 ? 526 THR A N     1 
ATOM   3593 C CA    . THR A 1 526 ? 96.419  88.708  115.340 1.00 275.57 ? 526 THR A CA    1 
ATOM   3594 C C     . THR A 1 526 ? 96.741  87.729  116.468 1.00 275.57 ? 526 THR A C     1 
ATOM   3595 O O     . THR A 1 526 ? 95.890  87.384  117.292 1.00 275.57 ? 526 THR A O     1 
ATOM   3596 C CB    . THR A 1 526 ? 97.362  89.908  115.368 1.00 275.57 ? 526 THR A CB    1 
ATOM   3597 O OG1   . THR A 1 526 ? 97.336  90.509  116.668 1.00 275.57 ? 526 THR A OG1   1 
ATOM   3598 C CG2   . THR A 1 526 ? 96.942  90.939  114.330 1.00 275.57 ? 526 THR A CG2   1 
ATOM   3599 N N     . LEU A 1 527 ? 97.996  87.268  116.509 1.00 229.85 ? 527 LEU A N     1 
ATOM   3600 C CA    . LEU A 1 527 ? 98.416  86.378  117.585 1.00 229.85 ? 527 LEU A CA    1 
ATOM   3601 C C     . LEU A 1 527 ? 98.476  87.088  118.930 1.00 229.85 ? 527 LEU A C     1 
ATOM   3602 O O     . LEU A 1 527 ? 98.433  86.421  119.970 1.00 229.85 ? 527 LEU A O     1 
ATOM   3603 C CB    . LEU A 1 527 ? 99.778  85.760  117.268 1.00 229.85 ? 527 LEU A CB    1 
ATOM   3604 C CG    . LEU A 1 527 ? 99.836  84.854  116.038 1.00 229.85 ? 527 LEU A CG    1 
ATOM   3605 C CD1   . LEU A 1 527 ? 101.207 84.207  115.920 1.00 229.85 ? 527 LEU A CD1   1 
ATOM   3606 C CD2   . LEU A 1 527 ? 98.745  83.799  116.102 1.00 229.85 ? 527 LEU A CD2   1 
ATOM   3607 N N     . SER A 1 528 ? 98.645  88.407  118.972 1.00 274.13 ? 528 SER A N     1 
ATOM   3608 C CA    . SER A 1 528 ? 98.471  89.153  120.222 1.00 274.13 ? 528 SER A CA    1 
ATOM   3609 C C     . SER A 1 528 ? 96.989  89.348  120.559 1.00 274.13 ? 528 SER A C     1 
ATOM   3610 O O     . SER A 1 528 ? 96.654  89.929  121.583 1.00 274.13 ? 528 SER A O     1 
ATOM   3611 C CB    . SER A 1 528 ? 99.162  90.509  120.122 1.00 274.13 ? 528 SER A CB    1 
ATOM   3612 O OG    . SER A 1 528 ? 98.523  91.308  119.151 1.00 274.13 ? 528 SER A OG    1 
ATOM   3613 N N     . ASN A 1 529 ? 96.087  88.901  119.683 1.00 316.08 ? 529 ASN A N     1 
ATOM   3614 C CA    . ASN A 1 529 ? 94.654  89.160  119.704 1.00 316.08 ? 529 ASN A CA    1 
ATOM   3615 C C     . ASN A 1 529 ? 94.276  90.650  119.646 1.00 316.08 ? 529 ASN A C     1 
ATOM   3616 O O     . ASN A 1 529 ? 93.167  91.042  120.008 1.00 316.08 ? 529 ASN A O     1 
ATOM   3617 C CB    . ASN A 1 529 ? 93.981  88.353  120.823 1.00 316.08 ? 529 ASN A CB    1 
ATOM   3618 C CG    . ASN A 1 529 ? 92.564  87.936  120.470 1.00 316.08 ? 529 ASN A CG    1 
ATOM   3619 O OD1   . ASN A 1 529 ? 92.021  88.242  119.420 1.00 316.08 ? 529 ASN A OD1   1 
ATOM   3620 N ND2   . ASN A 1 529 ? 91.934  87.171  121.328 1.00 316.08 ? 529 ASN A ND2   1 
ATOM   3621 N N     . ARG A 1 530 ? 95.176  91.484  119.108 1.00 357.79 ? 530 ARG A N     1 
ATOM   3622 C CA    . ARG A 1 530 ? 94.801  92.753  118.470 1.00 357.79 ? 530 ARG A CA    1 
ATOM   3623 C C     . ARG A 1 530 ? 93.741  92.456  117.408 1.00 357.79 ? 530 ARG A C     1 
ATOM   3624 O O     . ARG A 1 530 ? 93.848  91.426  116.743 1.00 357.79 ? 530 ARG A O     1 
ATOM   3625 C CB    . ARG A 1 530 ? 96.071  93.340  117.848 1.00 357.79 ? 530 ARG A CB    1 
ATOM   3626 C CG    . ARG A 1 530 ? 95.932  94.738  117.247 1.00 357.79 ? 530 ARG A CG    1 
ATOM   3627 C CD    . ARG A 1 530 ? 97.208  95.082  116.459 1.00 357.79 ? 530 ARG A CD    1 
ATOM   3628 N NE    . ARG A 1 530 ? 98.413  95.171  117.317 1.00 357.79 ? 530 ARG A NE    1 
ATOM   3629 C CZ    . ARG A 1 530 ? 98.815  96.219  118.009 1.00 357.79 ? 530 ARG A CZ    1 
ATOM   3630 N NH1   . ARG A 1 530 ? 99.960  96.187  118.620 1.00 357.79 ? 530 ARG A NH1   1 
ATOM   3631 N NH2   . ARG A 1 530 ? 98.100  97.302  118.105 1.00 357.79 ? 530 ARG A NH2   1 
ATOM   3632 N N     . LYS A 1 531 ? 92.735  93.318  117.245 1.00 372.51 ? 531 LYS A N     1 
ATOM   3633 C CA    . LYS A 1 531 ? 91.523  93.045  116.444 1.00 372.51 ? 531 LYS A CA    1 
ATOM   3634 C C     . LYS A 1 531 ? 91.170  94.153  115.456 1.00 372.51 ? 531 LYS A C     1 
ATOM   3635 O O     . LYS A 1 531 ? 91.568  95.297  115.644 1.00 372.51 ? 531 LYS A O     1 
ATOM   3636 C CB    . LYS A 1 531 ? 90.345  92.773  117.396 1.00 372.51 ? 531 LYS A CB    1 
ATOM   3637 C CG    . LYS A 1 531 ? 90.251  91.275  117.665 1.00 372.51 ? 531 LYS A CG    1 
ATOM   3638 C CD    . LYS A 1 531 ? 89.287  90.938  118.801 1.00 372.51 ? 531 LYS A CD    1 
ATOM   3639 C CE    . LYS A 1 531 ? 89.044  89.424  118.817 1.00 372.51 ? 531 LYS A CE    1 
ATOM   3640 N NZ    . LYS A 1 531 ? 88.153  89.024  119.933 1.00 372.51 ? 531 LYS A NZ    1 
ATOM   3641 N N     . VAL A 1 532 ? 90.413  93.831  114.406 1.00 426.61 ? 532 VAL A N     1 
ATOM   3642 C CA    . VAL A 1 532 ? 89.944  94.817  113.446 1.00 426.61 ? 532 VAL A CA    1 
ATOM   3643 C C     . VAL A 1 532 ? 88.587  94.351  112.940 1.00 426.61 ? 532 VAL A C     1 
ATOM   3644 O O     . VAL A 1 532 ? 88.308  93.145  112.902 1.00 426.61 ? 532 VAL A O     1 
ATOM   3645 C CB    . VAL A 1 532 ? 90.932  95.010  112.274 1.00 426.61 ? 532 VAL A CB    1 
ATOM   3646 C CG1   . VAL A 1 532 ? 90.944  93.788  111.366 1.00 426.61 ? 532 VAL A CG1   1 
ATOM   3647 C CG2   . VAL A 1 532 ? 90.610  96.279  111.491 1.00 426.61 ? 532 VAL A CG2   1 
ATOM   3648 N N     . ILE A 1 533 ? 87.748  95.306  112.548 1.00 456.33 ? 533 ILE A N     1 
ATOM   3649 C CA    . ILE A 1 533 ? 86.458  95.037  111.928 1.00 456.33 ? 533 ILE A CA    1 
ATOM   3650 C C     . ILE A 1 533 ? 86.396  95.817  110.625 1.00 456.33 ? 533 ILE A C     1 
ATOM   3651 O O     . ILE A 1 533 ? 86.534  97.047  110.623 1.00 456.33 ? 533 ILE A O     1 
ATOM   3652 C CB    . ILE A 1 533 ? 85.286  95.408  112.850 1.00 456.33 ? 533 ILE A CB    1 
ATOM   3653 C CG1   . ILE A 1 533 ? 85.276  94.506  114.086 1.00 456.33 ? 533 ILE A CG1   1 
ATOM   3654 C CG2   . ILE A 1 533 ? 83.966  95.308  112.101 1.00 456.33 ? 533 ILE A CG2   1 
ATOM   3655 C CD1   . ILE A 1 533 ? 84.130  94.780  115.034 1.00 456.33 ? 533 ILE A CD1   1 
ATOM   3656 N N     . PHE A 1 534 ? 86.198  95.108  109.531 1.00 556.40 ? 534 PHE A N     1 
ATOM   3657 C CA    . PHE A 1 534 ? 86.154  95.720  108.214 1.00 556.40 ? 534 PHE A CA    1 
ATOM   3658 C C     . PHE A 1 534 ? 84.809  96.413  107.990 1.00 556.40 ? 534 PHE A C     1 
ATOM   3659 O O     . PHE A 1 534 ? 83.791  95.989  108.543 1.00 556.40 ? 534 PHE A O     1 
ATOM   3660 C CB    . PHE A 1 534 ? 86.381  94.668  107.130 1.00 556.40 ? 534 PHE A CB    1 
ATOM   3661 C CG    . PHE A 1 534 ? 87.779  94.111  107.103 1.00 556.40 ? 534 PHE A CG    1 
ATOM   3662 C CD1   . PHE A 1 534 ? 88.824  94.786  107.712 1.00 556.40 ? 534 PHE A CD1   1 
ATOM   3663 C CD2   . PHE A 1 534 ? 88.045  92.906  106.470 1.00 556.40 ? 534 PHE A CD2   1 
ATOM   3664 C CE1   . PHE A 1 534 ? 90.108  94.273  107.689 1.00 556.40 ? 534 PHE A CE1   1 
ATOM   3665 C CE2   . PHE A 1 534 ? 89.325  92.387  106.442 1.00 556.40 ? 534 PHE A CE2   1 
ATOM   3666 C CZ    . PHE A 1 534 ? 90.358  93.071  107.053 1.00 556.40 ? 534 PHE A CZ    1 
ATOM   3667 N N     . PRO A 1 535 ? 84.781  97.479  107.184 1.00 652.42 ? 535 PRO A N     1 
ATOM   3668 C CA    . PRO A 1 535 ? 83.488  98.042  106.764 1.00 652.42 ? 535 PRO A CA    1 
ATOM   3669 C C     . PRO A 1 535 ? 82.766  97.148  105.775 1.00 652.42 ? 535 PRO A C     1 
ATOM   3670 O O     . PRO A 1 535 ? 81.530  97.159  105.720 1.00 652.42 ? 535 PRO A O     1 
ATOM   3671 C CB    . PRO A 1 535 ? 83.877  99.389  106.141 1.00 652.42 ? 535 PRO A CB    1 
ATOM   3672 C CG    . PRO A 1 535 ? 85.269  99.176  105.648 1.00 652.42 ? 535 PRO A CG    1 
ATOM   3673 C CD    . PRO A 1 535 ? 85.922  98.214  106.611 1.00 652.42 ? 535 PRO A CD    1 
ATOM   3674 N N     . TYR A 1 536 ? 83.515  96.375  104.994 1.00 655.58 ? 536 TYR A N     1 
ATOM   3675 C CA    . TYR A 1 536 ? 82.980  95.392  104.067 1.00 655.58 ? 536 TYR A CA    1 
ATOM   3676 C C     . TYR A 1 536 ? 84.063  94.344  103.871 1.00 655.58 ? 536 TYR A C     1 
ATOM   3677 O O     . TYR A 1 536 ? 85.230  94.571  104.197 1.00 655.58 ? 536 TYR A O     1 
ATOM   3678 C CB    . TYR A 1 536 ? 82.576  96.014  102.721 1.00 655.58 ? 536 TYR A CB    1 
ATOM   3679 C CG    . TYR A 1 536 ? 83.722  96.633  101.947 1.00 655.58 ? 536 TYR A CG    1 
ATOM   3680 C CD1   . TYR A 1 536 ? 84.204  97.897  102.268 1.00 655.58 ? 536 TYR A CD1   1 
ATOM   3681 C CD2   . TYR A 1 536 ? 84.317  95.954  100.890 1.00 655.58 ? 536 TYR A CD2   1 
ATOM   3682 C CE1   . TYR A 1 536 ? 85.251  98.462  101.561 1.00 655.58 ? 536 TYR A CE1   1 
ATOM   3683 C CE2   . TYR A 1 536 ? 85.361  96.514  100.177 1.00 655.58 ? 536 TYR A CE2   1 
ATOM   3684 C CZ    . TYR A 1 536 ? 85.825  97.767  100.517 1.00 655.58 ? 536 TYR A CZ    1 
ATOM   3685 O OH    . TYR A 1 536 ? 86.863  98.325  99.809  1.00 655.58 ? 536 TYR A OH    1 
ATOM   3686 N N     . PHE A 1 537 ? 83.684  93.196  103.323 1.00 539.06 ? 537 PHE A N     1 
ATOM   3687 C CA    . PHE A 1 537 ? 84.638  92.099  103.267 1.00 539.06 ? 537 PHE A CA    1 
ATOM   3688 C C     . PHE A 1 537 ? 85.559  92.269  102.075 1.00 539.06 ? 537 PHE A C     1 
ATOM   3689 O O     . PHE A 1 537 ? 85.110  92.435  100.936 1.00 539.06 ? 537 PHE A O     1 
ATOM   3690 C CB    . PHE A 1 537 ? 83.912  90.756  103.183 1.00 539.06 ? 537 PHE A CB    1 
ATOM   3691 C CG    . PHE A 1 537 ? 84.826  89.585  102.929 1.00 539.06 ? 537 PHE A CG    1 
ATOM   3692 C CD1   . PHE A 1 537 ? 85.689  89.132  103.912 1.00 539.06 ? 537 PHE A CD1   1 
ATOM   3693 C CD2   . PHE A 1 537 ? 84.821  88.939  101.702 1.00 539.06 ? 537 PHE A CD2   1 
ATOM   3694 C CE1   . PHE A 1 537 ? 86.528  88.057  103.679 1.00 539.06 ? 537 PHE A CE1   1 
ATOM   3695 C CE2   . PHE A 1 537 ? 85.658  87.865  101.464 1.00 539.06 ? 537 PHE A CE2   1 
ATOM   3696 C CZ    . PHE A 1 537 ? 86.513  87.423  102.453 1.00 539.06 ? 537 PHE A CZ    1 
ATOM   3697 N N     . SER A 1 538 ? 86.859  92.222  102.349 1.00 455.24 ? 538 SER A N     1 
ATOM   3698 C CA    . SER A 1 538 ? 87.883  92.206  101.319 1.00 455.24 ? 538 SER A CA    1 
ATOM   3699 C C     . SER A 1 538 ? 88.812  91.042  101.607 1.00 455.24 ? 538 SER A C     1 
ATOM   3700 O O     . SER A 1 538 ? 89.416  90.975  102.682 1.00 455.24 ? 538 SER A O     1 
ATOM   3701 C CB    . SER A 1 538 ? 88.661  93.525  101.282 1.00 455.24 ? 538 SER A CB    1 
ATOM   3702 O OG    . SER A 1 538 ? 89.862  93.386  100.543 1.00 455.24 ? 538 SER A OG    1 
ATOM   3703 N N     . PHE A 1 539 ? 88.904  90.123  100.649 1.00 337.15 ? 539 PHE A N     1 
ATOM   3704 C CA    . PHE A 1 539 ? 89.714  88.925  100.824 1.00 337.15 ? 539 PHE A CA    1 
ATOM   3705 C C     . PHE A 1 539 ? 91.160  89.314  101.103 1.00 337.15 ? 539 PHE A C     1 
ATOM   3706 O O     . PHE A 1 539 ? 91.796  88.790  102.030 1.00 337.15 ? 539 PHE A O     1 
ATOM   3707 C CB    . PHE A 1 539 ? 89.580  88.035  99.587  1.00 337.15 ? 539 PHE A CB    1 
ATOM   3708 C CG    . PHE A 1 539 ? 90.445  86.805  99.609  1.00 337.15 ? 539 PHE A CG    1 
ATOM   3709 C CD1   . PHE A 1 539 ? 90.278  85.852  100.602 1.00 337.15 ? 539 PHE A CD1   1 
ATOM   3710 C CD2   . PHE A 1 539 ? 91.370  86.566  98.609  1.00 337.15 ? 539 PHE A CD2   1 
ATOM   3711 C CE1   . PHE A 1 539 ? 91.048  84.707  100.621 1.00 337.15 ? 539 PHE A CE1   1 
ATOM   3712 C CE2   . PHE A 1 539 ? 92.140  85.417  98.620  1.00 337.15 ? 539 PHE A CE2   1 
ATOM   3713 C CZ    . PHE A 1 539 ? 91.976  84.486  99.629  1.00 337.15 ? 539 PHE A CZ    1 
ATOM   3714 N N     . THR A 1 540 ? 91.686  90.254  100.313 1.00 341.19 ? 540 THR A N     1 
ATOM   3715 C CA    . THR A 1 540 ? 93.096  90.611  100.394 1.00 341.19 ? 540 THR A CA    1 
ATOM   3716 C C     . THR A 1 540 ? 93.434  91.327  101.696 1.00 341.19 ? 540 THR A C     1 
ATOM   3717 O O     . THR A 1 540 ? 94.494  91.076  102.288 1.00 341.19 ? 540 THR A O     1 
ATOM   3718 C CB    . THR A 1 540 ? 93.443  91.525  99.218  1.00 341.19 ? 540 THR A CB    1 
ATOM   3719 O OG1   . THR A 1 540 ? 92.477  92.581  99.145  1.00 341.19 ? 540 THR A OG1   1 
ATOM   3720 C CG2   . THR A 1 540 ? 93.378  90.762  97.912  1.00 341.19 ? 540 THR A CG2   1 
ATOM   3721 N N     . LYS A 1 541 ? 92.527  92.162  102.207 1.00 376.60 ? 541 LYS A N     1 
ATOM   3722 C CA    . LYS A 1 541 ? 92.811  92.816  103.480 1.00 376.60 ? 541 LYS A CA    1 
ATOM   3723 C C     . LYS A 1 541 ? 92.691  91.828  104.631 1.00 376.60 ? 541 LYS A C     1 
ATOM   3724 O O     . LYS A 1 541 ? 93.442  91.908  105.615 1.00 376.60 ? 541 LYS A O     1 
ATOM   3725 C CB    . LYS A 1 541 ? 91.864  93.997  103.687 1.00 376.60 ? 541 LYS A CB    1 
ATOM   3726 C CG    . LYS A 1 541 ? 92.078  95.139  102.711 1.00 376.60 ? 541 LYS A CG    1 
ATOM   3727 C CD    . LYS A 1 541 ? 91.137  96.295  103.006 1.00 376.60 ? 541 LYS A CD    1 
ATOM   3728 C CE    . LYS A 1 541 ? 91.409  97.473  102.086 1.00 376.60 ? 541 LYS A CE    1 
ATOM   3729 N NZ    . LYS A 1 541 ? 90.642  98.681  102.498 1.00 376.60 ? 541 LYS A NZ    1 
ATOM   3730 N N     . ALA A 1 542 ? 91.784  90.856  104.496 1.00 390.68 ? 542 ALA A N     1 
ATOM   3731 C CA    . ALA A 1 542 ? 91.658  89.825  105.514 1.00 390.68 ? 542 ALA A CA    1 
ATOM   3732 C C     . ALA A 1 542 ? 92.916  88.982  105.577 1.00 390.68 ? 542 ALA A C     1 
ATOM   3733 O O     . ALA A 1 542 ? 93.329  88.555  106.661 1.00 390.68 ? 542 ALA A O     1 
ATOM   3734 C CB    . ALA A 1 542 ? 90.442  88.947  105.223 1.00 390.68 ? 542 ALA A CB    1 
ATOM   3735 N N     . LEU A 1 543 ? 93.532  88.726  104.423 1.00 371.69 ? 543 LEU A N     1 
ATOM   3736 C CA    . LEU A 1 543 ? 94.777  87.976  104.417 1.00 371.69 ? 543 LEU A CA    1 
ATOM   3737 C C     . LEU A 1 543 ? 95.933  88.808  104.961 1.00 371.69 ? 543 LEU A C     1 
ATOM   3738 O O     . LEU A 1 543 ? 96.807  88.276  105.653 1.00 371.69 ? 543 LEU A O     1 
ATOM   3739 C CB    . LEU A 1 543 ? 95.094  87.512  102.996 1.00 371.69 ? 543 LEU A CB    1 
ATOM   3740 C CG    . LEU A 1 543 ? 94.144  86.488  102.370 1.00 371.69 ? 543 LEU A CG    1 
ATOM   3741 C CD1   . LEU A 1 543 ? 94.618  86.139  100.977 1.00 371.69 ? 543 LEU A CD1   1 
ATOM   3742 C CD2   . LEU A 1 543 ? 93.977  85.239  103.216 1.00 371.69 ? 543 LEU A CD2   1 
ATOM   3743 N N     . ASN A 1 544 ? 95.949  90.109  104.655 1.00 354.32 ? 544 ASN A N     1 
ATOM   3744 C CA    . ASN A 1 544 ? 97.105  90.949  104.957 1.00 354.32 ? 544 ASN A CA    1 
ATOM   3745 C C     . ASN A 1 544 ? 97.173  91.387  106.420 1.00 354.32 ? 544 ASN A C     1 
ATOM   3746 O O     . ASN A 1 544 ? 98.270  91.528  106.972 1.00 354.32 ? 544 ASN A O     1 
ATOM   3747 C CB    . ASN A 1 544 ? 97.095  92.175  104.045 1.00 354.32 ? 544 ASN A CB    1 
ATOM   3748 C CG    . ASN A 1 544 ? 98.417  92.387  103.339 1.00 354.32 ? 544 ASN A CG    1 
ATOM   3749 O OD1   . ASN A 1 544 ? 99.483  92.156  103.911 1.00 354.32 ? 544 ASN A OD1   1 
ATOM   3750 N ND2   . ASN A 1 544 ? 98.355  92.826  102.087 1.00 354.32 ? 544 ASN A ND2   1 
ATOM   3751 N N     . TYR A 1 545 ? 96.025  91.609  107.063 1.00 357.80 ? 545 TYR A N     1 
ATOM   3752 C CA    . TYR A 1 545 ? 96.027  92.200  108.403 1.00 357.80 ? 545 TYR A CA    1 
ATOM   3753 C C     . TYR A 1 545 ? 96.717  91.393  109.505 1.00 357.80 ? 545 TYR A C     1 
ATOM   3754 O O     . TYR A 1 545 ? 97.576  91.964  110.203 1.00 357.80 ? 545 TYR A O     1 
ATOM   3755 C CB    . TYR A 1 545 ? 94.580  92.520  108.800 1.00 357.80 ? 545 TYR A CB    1 
ATOM   3756 C CG    . TYR A 1 545 ? 94.419  92.979  110.230 1.00 357.80 ? 545 TYR A CG    1 
ATOM   3757 C CD1   . TYR A 1 545 ? 94.623  94.304  110.587 1.00 357.80 ? 545 TYR A CD1   1 
ATOM   3758 C CD2   . TYR A 1 545 ? 94.060  92.078  111.227 1.00 357.80 ? 545 TYR A CD2   1 
ATOM   3759 C CE1   . TYR A 1 545 ? 94.475  94.718  111.896 1.00 357.80 ? 545 TYR A CE1   1 
ATOM   3760 C CE2   . TYR A 1 545 ? 93.914  92.482  112.537 1.00 357.80 ? 545 TYR A CE2   1 
ATOM   3761 C CZ    . TYR A 1 545 ? 94.120  93.802  112.865 1.00 357.80 ? 545 TYR A CZ    1 
ATOM   3762 O OH    . TYR A 1 545 ? 93.968  94.206  114.169 1.00 357.80 ? 545 TYR A OH    1 
ATOM   3763 N N     . PRO A 1 546 ? 96.405  90.110  109.730 1.00 353.58 ? 546 PRO A N     1 
ATOM   3764 C CA    . PRO A 1 546 ? 97.095  89.373  110.810 1.00 353.58 ? 546 PRO A CA    1 
ATOM   3765 C C     . PRO A 1 546 ? 98.608  89.293  110.696 1.00 353.58 ? 546 PRO A C     1 
ATOM   3766 O O     . PRO A 1 546 ? 99.298  89.425  111.717 1.00 353.58 ? 546 PRO A O     1 
ATOM   3767 C CB    . PRO A 1 546 ? 96.467  87.974  110.731 1.00 353.58 ? 546 PRO A CB    1 
ATOM   3768 C CG    . PRO A 1 546 ? 95.160  88.175  110.059 1.00 353.58 ? 546 PRO A CG    1 
ATOM   3769 C CD    . PRO A 1 546 ? 95.391  89.270  109.069 1.00 353.58 ? 546 PRO A CD    1 
ATOM   3770 N N     . VAL A 1 547 ? 99.151  89.247  109.482 1.00 323.83 ? 547 VAL A N     1 
ATOM   3771 C CA    . VAL A 1 547 ? 100.596 89.162  109.310 1.00 323.83 ? 547 VAL A CA    1 
ATOM   3772 C C     . VAL A 1 547 ? 101.277 90.463  109.702 1.00 323.83 ? 547 VAL A C     1 
ATOM   3773 O O     . VAL A 1 547 ? 102.216 90.472  110.511 1.00 323.83 ? 547 VAL A O     1 
ATOM   3774 C CB    . VAL A 1 547 ? 100.927 88.770  107.859 1.00 323.83 ? 547 VAL A CB    1 
ATOM   3775 C CG1   . VAL A 1 547 ? 102.413 88.867  107.617 1.00 323.83 ? 547 VAL A CG1   1 
ATOM   3776 C CG2   . VAL A 1 547 ? 100.425 87.365  107.565 1.00 323.83 ? 547 VAL A CG2   1 
ATOM   3777 N N     . GLN A 1 548 ? 100.822 91.582  109.145 1.00 337.50 ? 548 GLN A N     1 
ATOM   3778 C CA    . GLN A 1 548 ? 101.480 92.842  109.458 1.00 337.50 ? 548 GLN A CA    1 
ATOM   3779 C C     . GLN A 1 548 ? 101.254 93.224  110.915 1.00 337.50 ? 548 GLN A C     1 
ATOM   3780 O O     . GLN A 1 548 ? 102.160 93.763  111.565 1.00 337.50 ? 548 GLN A O     1 
ATOM   3781 C CB    . GLN A 1 548 ? 100.985 93.934  108.513 1.00 337.50 ? 548 GLN A CB    1 
ATOM   3782 C CG    . GLN A 1 548 ? 101.247 93.623  107.049 1.00 337.50 ? 548 GLN A CG    1 
ATOM   3783 C CD    . GLN A 1 548 ? 100.740 94.704  106.121 1.00 337.50 ? 548 GLN A CD    1 
ATOM   3784 O OE1   . GLN A 1 548 ? 99.764  95.387  106.426 1.00 337.50 ? 548 GLN A OE1   1 
ATOM   3785 N NE2   . GLN A 1 548 ? 101.396 94.861  104.978 1.00 337.50 ? 548 GLN A NE2   1 
ATOM   3786 N N     . GLY A 1 549 ? 100.059 92.962  111.453 1.00 322.37 ? 549 GLY A N     1 
ATOM   3787 C CA    . GLY A 1 549 ? 99.827  93.322  112.841 1.00 322.37 ? 549 GLY A CA    1 
ATOM   3788 C C     . GLY A 1 549 ? 100.651 92.483  113.803 1.00 322.37 ? 549 GLY A C     1 
ATOM   3789 O O     . GLY A 1 549 ? 101.117 92.980  114.835 1.00 322.37 ? 549 GLY A O     1 
ATOM   3790 N N     . THR A 1 550 ? 100.907 91.218  113.447 1.00 335.58 ? 550 THR A N     1 
ATOM   3791 C CA    . THR A 1 550 ? 101.779 90.405  114.287 1.00 335.58 ? 550 THR A CA    1 
ATOM   3792 C C     . THR A 1 550 ? 103.227 90.869  114.182 1.00 335.58 ? 550 THR A C     1 
ATOM   3793 O O     . THR A 1 550 ? 103.961 90.866  115.179 1.00 335.58 ? 550 THR A O     1 
ATOM   3794 C CB    . THR A 1 550 ? 101.647 88.930  113.912 1.00 335.58 ? 550 THR A CB    1 
ATOM   3795 O OG1   . THR A 1 550 ? 100.311 88.491  114.188 1.00 335.58 ? 550 THR A OG1   1 
ATOM   3796 C CG2   . THR A 1 550 ? 102.614 88.087  114.728 1.00 335.58 ? 550 THR A CG2   1 
ATOM   3797 N N     . CYS A 1 551 ? 103.667 91.240  112.974 1.00 252.24 ? 551 CYS A N     1 
ATOM   3798 C CA    . CYS A 1 551 ? 104.984 91.856  112.825 1.00 252.24 ? 551 CYS A CA    1 
ATOM   3799 C C     . CYS A 1 551 ? 105.130 93.075  113.730 1.00 252.24 ? 551 CYS A C     1 
ATOM   3800 O O     . CYS A 1 551 ? 106.162 93.253  114.393 1.00 252.24 ? 551 CYS A O     1 
ATOM   3801 C CB    . CYS A 1 551 ? 105.219 92.239  111.364 1.00 252.24 ? 551 CYS A CB    1 
ATOM   3802 S SG    . CYS A 1 551 ? 106.771 93.116  111.061 1.00 252.24 ? 551 CYS A SG    1 
ATOM   3803 N N     . ALA A 1 552 ? 104.109 93.936  113.744 1.00 332.15 ? 552 ALA A N     1 
ATOM   3804 C CA    . ALA A 1 552 ? 104.105 95.091  114.638 1.00 332.15 ? 552 ALA A CA    1 
ATOM   3805 C C     . ALA A 1 552 ? 104.252 94.671  116.096 1.00 332.15 ? 552 ALA A C     1 
ATOM   3806 O O     . ALA A 1 552 ? 105.083 95.224  116.828 1.00 332.15 ? 552 ALA A O     1 
ATOM   3807 C CB    . ALA A 1 552 ? 102.825 95.903  114.439 1.00 332.15 ? 552 ALA A CB    1 
ATOM   3808 N N     . ASP A 1 553 ? 103.440 93.702  116.535 1.00 314.44 ? 553 ASP A N     1 
ATOM   3809 C CA    . ASP A 1 553 ? 103.529 93.213  117.911 1.00 314.44 ? 553 ASP A CA    1 
ATOM   3810 C C     . ASP A 1 553 ? 104.940 92.735  118.240 1.00 314.44 ? 553 ASP A C     1 
ATOM   3811 O O     . ASP A 1 553 ? 105.481 93.055  119.309 1.00 314.44 ? 553 ASP A O     1 
ATOM   3812 C CB    . ASP A 1 553 ? 102.517 92.090  118.134 1.00 314.44 ? 553 ASP A CB    1 
ATOM   3813 C CG    . ASP A 1 553 ? 101.099 92.512  117.806 1.00 314.44 ? 553 ASP A CG    1 
ATOM   3814 O OD1   . ASP A 1 553 ? 100.756 93.687  118.053 1.00 314.44 ? 553 ASP A OD1   1 
ATOM   3815 O OD2   . ASP A 1 553 ? 100.331 91.670  117.294 1.00 314.44 ? 553 ASP A OD2   1 
ATOM   3816 N N     . ILE A 1 554 ? 105.549 91.976  117.331 1.00 343.03 ? 554 ILE A N     1 
ATOM   3817 C CA    . ILE A 1 554 ? 106.856 91.377  117.588 1.00 343.03 ? 554 ILE A CA    1 
ATOM   3818 C C     . ILE A 1 554 ? 107.921 92.460  117.707 1.00 343.03 ? 554 ILE A C     1 
ATOM   3819 O O     . ILE A 1 554 ? 108.729 92.465  118.645 1.00 343.03 ? 554 ILE A O     1 
ATOM   3820 C CB    . ILE A 1 554 ? 107.204 90.361  116.486 1.00 343.03 ? 554 ILE A CB    1 
ATOM   3821 C CG1   . ILE A 1 554 ? 106.327 89.116  116.615 1.00 343.03 ? 554 ILE A CG1   1 
ATOM   3822 C CG2   . ILE A 1 554 ? 108.676 89.986  116.550 1.00 343.03 ? 554 ILE A CG2   1 
ATOM   3823 C CD1   . ILE A 1 554 ? 106.334 88.238  115.386 1.00 343.03 ? 554 ILE A CD1   1 
ATOM   3824 N N     . LEU A 1 555 ? 107.925 93.404  116.761 1.00 381.84 ? 555 LEU A N     1 
ATOM   3825 C CA    . LEU A 1 555 ? 108.908 94.483  116.802 1.00 381.84 ? 555 LEU A CA    1 
ATOM   3826 C C     . LEU A 1 555 ? 108.746 95.316  118.068 1.00 381.84 ? 555 LEU A C     1 
ATOM   3827 O O     . LEU A 1 555 ? 109.737 95.701  118.702 1.00 381.84 ? 555 LEU A O     1 
ATOM   3828 C CB    . LEU A 1 555 ? 108.774 95.361  115.557 1.00 381.84 ? 555 LEU A CB    1 
ATOM   3829 C CG    . LEU A 1 555 ? 109.923 96.329  115.265 1.00 381.84 ? 555 LEU A CG    1 
ATOM   3830 C CD1   . LEU A 1 555 ? 111.138 95.575  114.744 1.00 381.84 ? 555 LEU A CD1   1 
ATOM   3831 C CD2   . LEU A 1 555 ? 109.493 97.408  114.281 1.00 381.84 ? 555 LEU A CD2   1 
ATOM   3832 N N     . LYS A 1 556 ? 107.504 95.617  118.442 1.00 432.74 ? 556 LYS A N     1 
ATOM   3833 C CA    . LYS A 1 556 ? 107.244 96.435  119.622 1.00 432.74 ? 556 LYS A CA    1 
ATOM   3834 C C     . LYS A 1 556 ? 107.685 95.731  120.903 1.00 432.74 ? 556 LYS A C     1 
ATOM   3835 O O     . LYS A 1 556 ? 108.264 96.362  121.799 1.00 432.74 ? 556 LYS A O     1 
ATOM   3836 C CB    . LYS A 1 556 ? 105.769 96.813  119.650 1.00 432.74 ? 556 LYS A CB    1 
ATOM   3837 C CG    . LYS A 1 556 ? 105.460 97.850  118.583 1.00 432.74 ? 556 LYS A CG    1 
ATOM   3838 C CD    . LYS A 1 556 ? 103.994 98.157  118.484 1.00 432.74 ? 556 LYS A CD    1 
ATOM   3839 C CE    . LYS A 1 556 ? 103.741 99.376  117.609 1.00 432.74 ? 556 LYS A CE    1 
ATOM   3840 N NZ    . LYS A 1 556 ? 102.303 99.760  117.577 1.00 432.74 ? 556 LYS A NZ    1 
ATOM   3841 N N     . LEU A 1 557 ? 107.445 94.423  121.008 1.00 303.11 ? 557 LEU A N     1 
ATOM   3842 C CA    . LEU A 1 557 ? 107.937 93.697  122.175 1.00 303.11 ? 557 LEU A CA    1 
ATOM   3843 C C     . LEU A 1 557 ? 109.460 93.652  122.181 1.00 303.11 ? 557 LEU A C     1 
ATOM   3844 O O     . LEU A 1 557 ? 110.090 93.677  123.250 1.00 303.11 ? 557 LEU A O     1 
ATOM   3845 C CB    . LEU A 1 557 ? 107.354 92.284  122.196 1.00 303.11 ? 557 LEU A CB    1 
ATOM   3846 C CG    . LEU A 1 557 ? 107.826 91.352  123.312 1.00 303.11 ? 557 LEU A CG    1 
ATOM   3847 C CD1   . LEU A 1 557 ? 107.594 91.983  124.676 1.00 303.11 ? 557 LEU A CD1   1 
ATOM   3848 C CD2   . LEU A 1 557 ? 107.129 90.006  123.213 1.00 303.11 ? 557 LEU A CD2   1 
ATOM   3849 N N     . ALA A 1 558 ? 110.077 93.611  120.995 1.00 292.73 ? 558 ALA A N     1 
ATOM   3850 C CA    . ALA A 1 558 ? 111.533 93.643  120.951 1.00 292.73 ? 558 ALA A CA    1 
ATOM   3851 C C     . ALA A 1 558 ? 112.041 94.990  121.442 1.00 292.73 ? 558 ALA A C     1 
ATOM   3852 O O     . ALA A 1 558 ? 113.057 95.064  122.139 1.00 292.73 ? 558 ALA A O     1 
ATOM   3853 C CB    . ALA A 1 558 ? 112.028 93.356  119.535 1.00 292.73 ? 558 ALA A CB    1 
ATOM   3854 N N     . LEU A 1 559 ? 111.301 96.059  121.137 1.00 394.04 ? 559 LEU A N     1 
ATOM   3855 C CA    . LEU A 1 559 ? 111.669 97.383  121.629 1.00 394.04 ? 559 LEU A CA    1 
ATOM   3856 C C     . LEU A 1 559 ? 111.494 97.476  123.139 1.00 394.04 ? 559 LEU A C     1 
ATOM   3857 O O     . LEU A 1 559 ? 112.286 98.135  123.821 1.00 394.04 ? 559 LEU A O     1 
ATOM   3858 C CB    . LEU A 1 559 ? 110.842 98.464  120.934 1.00 394.04 ? 559 LEU A CB    1 
ATOM   3859 C CG    . LEU A 1 559 ? 111.063 98.725  119.445 1.00 394.04 ? 559 LEU A CG    1 
ATOM   3860 C CD1   . LEU A 1 559 ? 109.997 99.662  118.910 1.00 394.04 ? 559 LEU A CD1   1 
ATOM   3861 C CD2   . LEU A 1 559 ? 112.438 99.334  119.238 1.00 394.04 ? 559 LEU A CD2   1 
ATOM   3862 N N     . VAL A 1 560 ? 110.500 96.773  123.686 1.00 254.12 ? 560 VAL A N     1 
ATOM   3863 C CA    . VAL A 1 560 ? 110.269 96.818  125.130 1.00 254.12 ? 560 VAL A CA    1 
ATOM   3864 C C     . VAL A 1 560 ? 111.404 96.123  125.866 1.00 254.12 ? 560 VAL A C     1 
ATOM   3865 O O     . VAL A 1 560 ? 112.013 96.676  126.801 1.00 254.12 ? 560 VAL A O     1 
ATOM   3866 C CB    . VAL A 1 560 ? 108.922 96.161  125.482 1.00 254.12 ? 560 VAL A CB    1 
ATOM   3867 C CG1   . VAL A 1 560 ? 108.786 96.032  126.990 1.00 254.12 ? 560 VAL A CG1   1 
ATOM   3868 C CG2   . VAL A 1 560 ? 107.770 96.930  124.899 1.00 254.12 ? 560 VAL A CG2   1 
ATOM   3869 N N     . ASP A 1 561 ? 111.731 94.907  125.425 1.00 311.71 ? 561 ASP A N     1 
ATOM   3870 C CA    . ASP A 1 561 ? 112.850 94.198  126.027 1.00 311.71 ? 561 ASP A CA    1 
ATOM   3871 C C     . ASP A 1 561 ? 114.147 94.974  125.848 1.00 311.71 ? 561 ASP A C     1 
ATOM   3872 O O     . ASP A 1 561 ? 114.960 95.044  126.775 1.00 311.71 ? 561 ASP A O     1 
ATOM   3873 C CB    . ASP A 1 561 ? 112.974 92.798  125.428 1.00 311.71 ? 561 ASP A CB    1 
ATOM   3874 C CG    . ASP A 1 561 ? 113.808 91.873  126.290 1.00 311.71 ? 561 ASP A CG    1 
ATOM   3875 O OD1   . ASP A 1 561 ? 113.287 91.387  127.315 1.00 311.71 ? 561 ASP A OD1   1 
ATOM   3876 O OD2   . ASP A 1 561 ? 114.985 91.637  125.949 1.00 311.71 ? 561 ASP A OD2   1 
ATOM   3877 N N     . LEU A 1 562 ? 114.372 95.542  124.664 1.00 315.44 ? 562 LEU A N     1 
ATOM   3878 C CA    . LEU A 1 562 ? 115.606 96.281  124.436 1.00 315.44 ? 562 LEU A CA    1 
ATOM   3879 C C     . LEU A 1 562 ? 115.706 97.486  125.364 1.00 315.44 ? 562 LEU A C     1 
ATOM   3880 O O     . LEU A 1 562 ? 116.765 97.751  125.947 1.00 315.44 ? 562 LEU A O     1 
ATOM   3881 C CB    . LEU A 1 562 ? 115.655 96.721  122.976 1.00 315.44 ? 562 LEU A CB    1 
ATOM   3882 C CG    . LEU A 1 562 ? 116.871 97.459  122.436 1.00 315.44 ? 562 LEU A CG    1 
ATOM   3883 C CD1   . LEU A 1 562 ? 118.124 96.604  122.547 1.00 315.44 ? 562 LEU A CD1   1 
ATOM   3884 C CD2   . LEU A 1 562 ? 116.592 97.863  121.006 1.00 315.44 ? 562 LEU A CD2   1 
ATOM   3885 N N     . TYR A 1 563 ? 114.605 98.229  125.518 1.00 240.81 ? 563 TYR A N     1 
ATOM   3886 C CA    . TYR A 1 563 ? 114.615 99.402  126.385 1.00 240.81 ? 563 TYR A CA    1 
ATOM   3887 C C     . TYR A 1 563 ? 114.912 99.028  127.824 1.00 240.81 ? 563 TYR A C     1 
ATOM   3888 O O     . TYR A 1 563 ? 115.584 99.777  128.545 1.00 240.81 ? 563 TYR A O     1 
ATOM   3889 C CB    . TYR A 1 563 ? 113.291 100.147 126.315 1.00 240.81 ? 563 TYR A CB    1 
ATOM   3890 C CG    . TYR A 1 563 ? 113.246 101.338 127.243 1.00 240.81 ? 563 TYR A CG    1 
ATOM   3891 C CD1   . TYR A 1 563 ? 113.768 102.564 126.855 1.00 240.81 ? 563 TYR A CD1   1 
ATOM   3892 C CD2   . TYR A 1 563 ? 112.712 101.230 128.522 1.00 240.81 ? 563 TYR A CD2   1 
ATOM   3893 C CE1   . TYR A 1 563 ? 113.741 103.651 127.701 1.00 240.81 ? 563 TYR A CE1   1 
ATOM   3894 C CE2   . TYR A 1 563 ? 112.691 102.309 129.377 1.00 240.81 ? 563 TYR A CE2   1 
ATOM   3895 C CZ    . TYR A 1 563 ? 113.201 103.519 128.961 1.00 240.81 ? 563 TYR A CZ    1 
ATOM   3896 O OH    . TYR A 1 563 ? 113.174 104.601 129.809 1.00 240.81 ? 563 TYR A OH    1 
ATOM   3897 N N     . ASP A 1 564 ? 114.422 97.870  128.266 1.00 235.19 ? 564 ASP A N     1 
ATOM   3898 C CA    . ASP A 1 564 ? 114.752 97.480  129.630 1.00 235.19 ? 564 ASP A CA    1 
ATOM   3899 C C     . ASP A 1 564 ? 116.186 96.985  129.744 1.00 235.19 ? 564 ASP A C     1 
ATOM   3900 O O     . ASP A 1 564 ? 116.862 97.278  130.736 1.00 235.19 ? 564 ASP A O     1 
ATOM   3901 C CB    . ASP A 1 564 ? 113.774 96.411  130.117 1.00 235.19 ? 564 ASP A CB    1 
ATOM   3902 C CG    . ASP A 1 564 ? 112.407 96.982  130.444 1.00 235.19 ? 564 ASP A CG    1 
ATOM   3903 O OD1   . ASP A 1 564 ? 112.260 98.222  130.420 1.00 235.19 ? 564 ASP A OD1   1 
ATOM   3904 O OD2   . ASP A 1 564 ? 111.482 96.193  130.723 1.00 235.19 ? 564 ASP A OD2   1 
ATOM   3905 N N     . ASN A 1 565 ? 116.661 96.246  128.749 1.00 316.10 ? 565 ASN A N     1 
ATOM   3906 C CA    . ASN A 1 565 ? 117.983 95.639  128.781 1.00 316.10 ? 565 ASN A CA    1 
ATOM   3907 C C     . ASN A 1 565 ? 119.114 96.631  128.529 1.00 316.10 ? 565 ASN A C     1 
ATOM   3908 O O     . ASN A 1 565 ? 120.270 96.311  128.826 1.00 316.10 ? 565 ASN A O     1 
ATOM   3909 C CB    . ASN A 1 565 ? 118.058 94.501  127.763 1.00 316.10 ? 565 ASN A CB    1 
ATOM   3910 C CG    . ASN A 1 565 ? 117.152 93.340  128.117 1.00 316.10 ? 565 ASN A CG    1 
ATOM   3911 O OD1   . ASN A 1 565 ? 116.797 93.147  129.280 1.00 316.10 ? 565 ASN A OD1   1 
ATOM   3912 N ND2   . ASN A 1 565 ? 116.776 92.558  127.114 1.00 316.10 ? 565 ASN A ND2   1 
ATOM   3913 N N     . LEU A 1 566 ? 118.820 97.818  127.992 1.00 289.20 ? 566 LEU A N     1 
ATOM   3914 C CA    . LEU A 1 566 ? 119.863 98.778  127.651 1.00 289.20 ? 566 LEU A CA    1 
ATOM   3915 C C     . LEU A 1 566 ? 120.192 99.760  128.763 1.00 289.20 ? 566 LEU A C     1 
ATOM   3916 O O     . LEU A 1 566 ? 121.198 100.469 128.649 1.00 289.20 ? 566 LEU A O     1 
ATOM   3917 C CB    . LEU A 1 566 ? 119.480 99.584  126.405 1.00 289.20 ? 566 LEU A CB    1 
ATOM   3918 C CG    . LEU A 1 566 ? 119.559 98.921  125.033 1.00 289.20 ? 566 LEU A CG    1 
ATOM   3919 C CD1   . LEU A 1 566 ? 119.040 99.880  123.975 1.00 289.20 ? 566 LEU A CD1   1 
ATOM   3920 C CD2   . LEU A 1 566 ? 120.984 98.493  124.724 1.00 289.20 ? 566 LEU A CD2   1 
ATOM   3921 N N     . LYS A 1 567 ? 119.370 99.846  129.811 1.00 292.45 ? 567 LYS A N     1 
ATOM   3922 C CA    . LYS A 1 567 ? 119.628 100.835 130.853 1.00 292.45 ? 567 LYS A CA    1 
ATOM   3923 C C     . LYS A 1 567 ? 121.011 100.638 131.457 1.00 292.45 ? 567 LYS A C     1 
ATOM   3924 O O     . LYS A 1 567 ? 121.726 101.610 131.725 1.00 292.45 ? 567 LYS A O     1 
ATOM   3925 C CB    . LYS A 1 567 ? 118.551 100.747 131.934 1.00 292.45 ? 567 LYS A CB    1 
ATOM   3926 C CG    . LYS A 1 567 ? 117.146 101.015 131.428 1.00 292.45 ? 567 LYS A CG    1 
ATOM   3927 C CD    . LYS A 1 567 ? 116.157 101.087 132.577 1.00 292.45 ? 567 LYS A CD    1 
ATOM   3928 C CE    . LYS A 1 567 ? 114.748 101.352 132.074 1.00 292.45 ? 567 LYS A CE    1 
ATOM   3929 N NZ    . LYS A 1 567 ? 113.752 101.338 133.180 1.00 292.45 ? 567 LYS A NZ    1 
ATOM   3930 N N     . ASP A 1 568 ? 121.396 99.379  131.686 1.00 333.76 ? 568 ASP A N     1 
ATOM   3931 C CA    . ASP A 1 568 ? 122.656 99.059  132.345 1.00 333.76 ? 568 ASP A CA    1 
ATOM   3932 C C     . ASP A 1 568 ? 123.864 99.648  131.624 1.00 333.76 ? 568 ASP A C     1 
ATOM   3933 O O     . ASP A 1 568 ? 124.839 100.025 132.282 1.00 333.76 ? 568 ASP A O     1 
ATOM   3934 C CB    . ASP A 1 568 ? 122.810 97.544  132.467 1.00 333.76 ? 568 ASP A CB    1 
ATOM   3935 C CG    . ASP A 1 568 ? 121.634 96.896  133.170 1.00 333.76 ? 568 ASP A CG    1 
ATOM   3936 O OD1   . ASP A 1 568 ? 121.023 97.554  134.039 1.00 333.76 ? 568 ASP A OD1   1 
ATOM   3937 O OD2   . ASP A 1 568 ? 121.318 95.731  132.852 1.00 333.76 ? 568 ASP A OD2   1 
ATOM   3938 N N     . ILE A 1 569 ? 123.819 99.735  130.296 1.00 355.48 ? 569 ILE A N     1 
ATOM   3939 C CA    . ILE A 1 569 ? 124.917 100.264 129.496 1.00 355.48 ? 569 ILE A CA    1 
ATOM   3940 C C     . ILE A 1 569 ? 124.554 101.582 128.828 1.00 355.48 ? 569 ILE A C     1 
ATOM   3941 O O     . ILE A 1 569 ? 125.198 101.971 127.847 1.00 355.48 ? 569 ILE A O     1 
ATOM   3942 C CB    . ILE A 1 569 ? 125.392 99.241  128.451 1.00 355.48 ? 569 ILE A CB    1 
ATOM   3943 C CG1   . ILE A 1 569 ? 124.272 98.928  127.458 1.00 355.48 ? 569 ILE A CG1   1 
ATOM   3944 C CG2   . ILE A 1 569 ? 125.877 97.971  129.130 1.00 355.48 ? 569 ILE A CG2   1 
ATOM   3945 C CD1   . ILE A 1 569 ? 124.707 98.045  126.309 1.00 355.48 ? 569 ILE A CD1   1 
ATOM   3946 N N     . ASN A 1 570 ? 123.551 102.295 129.348 1.00 391.99 ? 570 ASN A N     1 
ATOM   3947 C CA    . ASN A 1 570 ? 123.123 103.583 128.800 1.00 391.99 ? 570 ASN A CA    1 
ATOM   3948 C C     . ASN A 1 570 ? 122.893 103.513 127.292 1.00 391.99 ? 570 ASN A C     1 
ATOM   3949 O O     . ASN A 1 570 ? 123.265 104.423 126.548 1.00 391.99 ? 570 ASN A O     1 
ATOM   3950 C CB    . ASN A 1 570 ? 124.127 104.689 129.139 1.00 391.99 ? 570 ASN A CB    1 
ATOM   3951 C CG    . ASN A 1 570 ? 123.553 106.080 128.946 1.00 391.99 ? 570 ASN A CG    1 
ATOM   3952 O OD1   . ASN A 1 570 ? 122.336 106.266 128.942 1.00 391.99 ? 570 ASN A OD1   1 
ATOM   3953 N ND2   . ASN A 1 570 ? 124.428 107.065 128.781 1.00 391.99 ? 570 ASN A ND2   1 
ATOM   3954 N N     . GLY A 1 571 ? 122.287 102.422 126.829 1.00 331.26 ? 571 GLY A N     1 
ATOM   3955 C CA    . GLY A 1 571 ? 122.000 102.287 125.416 1.00 331.26 ? 571 GLY A CA    1 
ATOM   3956 C C     . GLY A 1 571 ? 120.930 103.263 124.966 1.00 331.26 ? 571 GLY A C     1 
ATOM   3957 O O     . GLY A 1 571 ? 120.059 103.673 125.733 1.00 331.26 ? 571 GLY A O     1 
ATOM   3958 N N     . LYS A 1 572 ? 121.000 103.638 123.691 1.00 346.15 ? 572 LYS A N     1 
ATOM   3959 C CA    . LYS A 1 572 ? 120.078 104.595 123.098 1.00 346.15 ? 572 LYS A CA    1 
ATOM   3960 C C     . LYS A 1 572 ? 119.311 103.915 121.976 1.00 346.15 ? 572 LYS A C     1 
ATOM   3961 O O     . LYS A 1 572 ? 119.914 103.301 121.090 1.00 346.15 ? 572 LYS A O     1 
ATOM   3962 C CB    . LYS A 1 572 ? 120.826 105.811 122.548 1.00 346.15 ? 572 LYS A CB    1 
ATOM   3963 C CG    . LYS A 1 572 ? 121.617 106.595 123.581 1.00 346.15 ? 572 LYS A CG    1 
ATOM   3964 C CD    . LYS A 1 572 ? 122.177 107.874 122.973 1.00 346.15 ? 572 LYS A CD    1 
ATOM   3965 C CE    . LYS A 1 572 ? 123.126 108.578 123.930 1.00 346.15 ? 572 LYS A CE    1 
ATOM   3966 N NZ    . LYS A 1 572 ? 123.617 109.868 123.370 1.00 346.15 ? 572 LYS A NZ    1 
ATOM   3967 N N     . ILE A 1 573 ? 117.988 104.029 122.013 1.00 302.53 ? 573 ILE A N     1 
ATOM   3968 C CA    . ILE A 1 573 ? 117.157 103.541 120.920 1.00 302.53 ? 573 ILE A CA    1 
ATOM   3969 C C     . ILE A 1 573 ? 117.030 104.635 119.872 1.00 302.53 ? 573 ILE A C     1 
ATOM   3970 O O     . ILE A 1 573 ? 116.647 105.770 120.181 1.00 302.53 ? 573 ILE A O     1 
ATOM   3971 C CB    . ILE A 1 573 ? 115.776 103.113 121.438 1.00 302.53 ? 573 ILE A CB    1 
ATOM   3972 C CG1   . ILE A 1 573 ? 115.921 102.112 122.586 1.00 302.53 ? 573 ILE A CG1   1 
ATOM   3973 C CG2   . ILE A 1 573 ? 114.940 102.529 120.311 1.00 302.53 ? 573 ILE A CG2   1 
ATOM   3974 C CD1   . ILE A 1 573 ? 114.616 101.784 123.273 1.00 302.53 ? 573 ILE A CD1   1 
ATOM   3975 N N     . ILE A 1 574 ? 117.366 104.302 118.632 1.00 303.16 ? 574 ILE A N     1 
ATOM   3976 C CA    . ILE A 1 574 ? 117.441 105.269 117.546 1.00 303.16 ? 574 ILE A CA    1 
ATOM   3977 C C     . ILE A 1 574 ? 116.239 105.156 116.616 1.00 303.16 ? 574 ILE A C     1 
ATOM   3978 O O     . ILE A 1 574 ? 115.544 106.140 116.362 1.00 303.16 ? 574 ILE A O     1 
ATOM   3979 C CB    . ILE A 1 574 ? 118.765 105.130 116.766 1.00 303.16 ? 574 ILE A CB    1 
ATOM   3980 C CG1   . ILE A 1 574 ? 119.939 105.306 117.721 1.00 303.16 ? 574 ILE A CG1   1 
ATOM   3981 C CG2   . ILE A 1 574 ? 118.830 106.147 115.641 1.00 303.16 ? 574 ILE A CG2   1 
ATOM   3982 C CD1   . ILE A 1 574 ? 119.951 106.650 118.423 1.00 303.16 ? 574 ILE A CD1   1 
ATOM   3983 N N     . LEU A 1 575 ? 115.978 103.956 116.103 1.00 348.31 ? 575 LEU A N     1 
ATOM   3984 C CA    . LEU A 1 575 ? 115.088 103.818 114.959 1.00 348.31 ? 575 LEU A CA    1 
ATOM   3985 C C     . LEU A 1 575 ? 114.436 102.446 114.957 1.00 348.31 ? 575 LEU A C     1 
ATOM   3986 O O     . LEU A 1 575 ? 115.012 101.464 115.428 1.00 348.31 ? 575 LEU A O     1 
ATOM   3987 C CB    . LEU A 1 575 ? 115.850 104.029 113.646 1.00 348.31 ? 575 LEU A CB    1 
ATOM   3988 C CG    . LEU A 1 575 ? 115.607 105.344 112.909 1.00 348.31 ? 575 LEU A CG    1 
ATOM   3989 C CD1   . LEU A 1 575 ? 116.794 105.684 112.024 1.00 348.31 ? 575 LEU A CD1   1 
ATOM   3990 C CD2   . LEU A 1 575 ? 114.338 105.237 112.087 1.00 348.31 ? 575 LEU A CD2   1 
ATOM   3991 N N     . CYS A 1 576 ? 113.228 102.394 114.402 1.00 289.01 ? 576 CYS A N     1 
ATOM   3992 C CA    . CYS A 1 576 ? 112.515 101.153 114.127 1.00 289.01 ? 576 CYS A CA    1 
ATOM   3993 C C     . CYS A 1 576 ? 111.788 101.329 112.804 1.00 289.01 ? 576 CYS A C     1 
ATOM   3994 O O     . CYS A 1 576 ? 110.888 102.169 112.696 1.00 289.01 ? 576 CYS A O     1 
ATOM   3995 C CB    . CYS A 1 576 ? 111.540 100.796 115.253 1.00 289.01 ? 576 CYS A CB    1 
ATOM   3996 S SG    . CYS A 1 576 ? 110.350 102.081 115.680 1.00 289.01 ? 576 CYS A SG    1 
ATOM   3997 N N     . VAL A 1 577 ? 112.176 100.554 111.796 1.00 433.91 ? 577 VAL A N     1 
ATOM   3998 C CA    . VAL A 1 577 ? 111.522 100.603 110.492 1.00 433.91 ? 577 VAL A CA    1 
ATOM   3999 C C     . VAL A 1 577 ? 111.300 99.161  110.059 1.00 433.91 ? 577 VAL A C     1 
ATOM   4000 O O     . VAL A 1 577 ? 112.175 98.312  110.252 1.00 433.91 ? 577 VAL A O     1 
ATOM   4001 C CB    . VAL A 1 577 ? 112.370 101.372 109.469 1.00 433.91 ? 577 VAL A CB    1 
ATOM   4002 C CG1   . VAL A 1 577 ? 111.894 101.120 108.042 1.00 433.91 ? 577 VAL A CG1   1 
ATOM   4003 C CG2   . VAL A 1 577 ? 112.386 102.862 109.788 1.00 433.91 ? 577 VAL A CG2   1 
ATOM   4004 N N     . HIS A 1 578 ? 110.160 98.900  109.409 1.00 496.90 ? 578 HIS A N     1 
ATOM   4005 C CA    . HIS A 1 578 ? 109.806 97.565  108.933 1.00 496.90 ? 578 HIS A CA    1 
ATOM   4006 C C     . HIS A 1 578 ? 109.956 96.575  110.080 1.00 496.90 ? 578 HIS A C     1 
ATOM   4007 O O     . HIS A 1 578 ? 109.290 96.698  111.112 1.00 496.90 ? 578 HIS A O     1 
ATOM   4008 C CB    . HIS A 1 578 ? 110.679 97.159  107.743 1.00 496.90 ? 578 HIS A CB    1 
ATOM   4009 C CG    . HIS A 1 578 ? 110.544 98.062  106.557 1.00 496.90 ? 578 HIS A CG    1 
ATOM   4010 N ND1   . HIS A 1 578 ? 109.363 98.702  106.238 1.00 496.90 ? 578 HIS A ND1   1 
ATOM   4011 C CD2   . HIS A 1 578 ? 111.444 98.440  105.616 1.00 496.90 ? 578 HIS A CD2   1 
ATOM   4012 C CE1   . HIS A 1 578 ? 109.541 99.430  105.151 1.00 496.90 ? 578 HIS A CE1   1 
ATOM   4013 N NE2   . HIS A 1 578 ? 110.794 99.289  104.753 1.00 496.90 ? 578 HIS A NE2   1 
ATOM   4014 N N     . ASP A 1 579 ? 110.826 95.585  109.899 1.00 413.05 ? 579 ASP A N     1 
ATOM   4015 C CA    . ASP A 1 579 ? 111.108 94.576  110.909 1.00 413.05 ? 579 ASP A CA    1 
ATOM   4016 C C     . ASP A 1 579 ? 112.529 94.701  111.436 1.00 413.05 ? 579 ASP A C     1 
ATOM   4017 O O     . ASP A 1 579 ? 113.134 93.699  111.825 1.00 413.05 ? 579 ASP A O     1 
ATOM   4018 C CB    . ASP A 1 579 ? 110.867 93.175  110.345 1.00 413.05 ? 579 ASP A CB    1 
ATOM   4019 C CG    . ASP A 1 579 ? 111.524 92.970  109.000 1.00 413.05 ? 579 ASP A CG    1 
ATOM   4020 O OD1   . ASP A 1 579 ? 111.663 93.958  108.249 1.00 413.05 ? 579 ASP A OD1   1 
ATOM   4021 O OD2   . ASP A 1 579 ? 111.897 91.819  108.690 1.00 413.05 ? 579 ASP A OD2   1 
ATOM   4022 N N     . GLU A 1 580 ? 113.070 95.914  111.446 1.00 392.50 ? 580 GLU A N     1 
ATOM   4023 C CA    . GLU A 1 580 ? 114.443 96.185  111.836 1.00 392.50 ? 580 GLU A CA    1 
ATOM   4024 C C     . GLU A 1 580 ? 114.482 97.314  112.860 1.00 392.50 ? 580 GLU A C     1 
ATOM   4025 O O     . GLU A 1 580 ? 113.635 98.216  112.846 1.00 392.50 ? 580 GLU A O     1 
ATOM   4026 C CB    . GLU A 1 580 ? 115.270 96.539  110.595 1.00 392.50 ? 580 GLU A CB    1 
ATOM   4027 C CG    . GLU A 1 580 ? 115.670 97.995  110.467 1.00 392.50 ? 580 GLU A CG    1 
ATOM   4028 C CD    . GLU A 1 580 ? 116.551 98.240  109.258 1.00 392.50 ? 580 GLU A CD    1 
ATOM   4029 O OE1   . GLU A 1 580 ? 117.746 97.882  109.306 1.00 392.50 ? 580 GLU A OE1   1 
ATOM   4030 O OE2   . GLU A 1 580 ? 116.039 98.772  108.248 1.00 392.50 ? 580 GLU A OE2   1 
ATOM   4031 N N     . ILE A 1 581 ? 115.475 97.252  113.745 1.00 400.79 ? 581 ILE A N     1 
ATOM   4032 C CA    . ILE A 1 581 ? 115.730 98.279  114.749 1.00 400.79 ? 581 ILE A CA    1 
ATOM   4033 C C     . ILE A 1 581 ? 117.187 98.723  114.673 1.00 400.79 ? 581 ILE A C     1 
ATOM   4034 O O     . ILE A 1 581 ? 118.082 97.906  114.413 1.00 400.79 ? 581 ILE A O     1 
ATOM   4035 C CB    . ILE A 1 581 ? 115.389 97.753  116.157 1.00 400.79 ? 581 ILE A CB    1 
ATOM   4036 C CG1   . ILE A 1 581 ? 113.896 97.442  116.254 1.00 400.79 ? 581 ILE A CG1   1 
ATOM   4037 C CG2   . ILE A 1 581 ? 115.770 98.762  117.230 1.00 400.79 ? 581 ILE A CG2   1 
ATOM   4038 C CD1   . ILE A 1 581 ? 113.543 96.524  117.402 1.00 400.79 ? 581 ILE A CD1   1 
ATOM   4039 N N     . ILE A 1 582 ? 117.425 100.012 114.911 1.00 332.01 ? 582 ILE A N     1 
ATOM   4040 C CA    . ILE A 1 582 ? 118.764 100.588 114.961 1.00 332.01 ? 582 ILE A CA    1 
ATOM   4041 C C     . ILE A 1 582 ? 118.924 101.232 116.330 1.00 332.01 ? 582 ILE A C     1 
ATOM   4042 O O     . ILE A 1 582 ? 118.070 102.024 116.752 1.00 332.01 ? 582 ILE A O     1 
ATOM   4043 C CB    . ILE A 1 582 ? 118.992 101.619 113.849 1.00 332.01 ? 582 ILE A CB    1 
ATOM   4044 C CG1   . ILE A 1 582 ? 118.737 100.995 112.481 1.00 332.01 ? 582 ILE A CG1   1 
ATOM   4045 C CG2   . ILE A 1 582 ? 120.406 102.176 113.924 1.00 332.01 ? 582 ILE A CG2   1 
ATOM   4046 C CD1   . ILE A 1 582 ? 118.930 101.962 111.357 1.00 332.01 ? 582 ILE A CD1   1 
ATOM   4047 N N     . ILE A 1 583 ? 120.014 100.896 117.015 1.00 338.15 ? 583 ILE A N     1 
ATOM   4048 C CA    . ILE A 1 583 ? 120.409 101.514 118.275 1.00 338.15 ? 583 ILE A CA    1 
ATOM   4049 C C     . ILE A 1 583 ? 121.775 102.162 118.119 1.00 338.15 ? 583 ILE A C     1 
ATOM   4050 O O     . ILE A 1 583 ? 122.523 101.857 117.189 1.00 338.15 ? 583 ILE A O     1 
ATOM   4051 C CB    . ILE A 1 583 ? 120.430 100.506 119.444 1.00 338.15 ? 583 ILE A CB    1 
ATOM   4052 C CG1   . ILE A 1 583 ? 121.395 99.358  119.147 1.00 338.15 ? 583 ILE A CG1   1 
ATOM   4053 C CG2   . ILE A 1 583 ? 119.035 99.994  119.713 1.00 338.15 ? 583 ILE A CG2   1 
ATOM   4054 C CD1   . ILE A 1 583 ? 121.591 98.408  120.309 1.00 338.15 ? 583 ILE A CD1   1 
ATOM   4055 N N     . GLU A 1 584 ? 122.083 103.094 119.017 1.00 333.30 ? 584 GLU A N     1 
ATOM   4056 C CA    . GLU A 1 584 ? 123.373 103.765 119.032 1.00 333.30 ? 584 GLU A CA    1 
ATOM   4057 C C     . GLU A 1 584 ? 123.954 103.566 120.420 1.00 333.30 ? 584 GLU A C     1 
ATOM   4058 O O     . GLU A 1 584 ? 123.296 103.873 121.420 1.00 333.30 ? 584 GLU A O     1 
ATOM   4059 C CB    . GLU A 1 584 ? 123.247 105.254 118.719 1.00 333.30 ? 584 GLU A CB    1 
ATOM   4060 C CG    . GLU A 1 584 ? 124.571 105.972 118.577 1.00 333.30 ? 584 GLU A CG    1 
ATOM   4061 C CD    . GLU A 1 584 ? 124.398 107.435 118.229 1.00 333.30 ? 584 GLU A CD    1 
ATOM   4062 O OE1   . GLU A 1 584 ? 123.346 107.796 117.661 1.00 333.30 ? 584 GLU A OE1   1 
ATOM   4063 O OE2   . GLU A 1 584 ? 125.315 108.226 118.529 1.00 333.30 ? 584 GLU A OE2   1 
ATOM   4064 N N     . VAL A 1 585 ? 125.184 103.056 120.481 1.00 304.34 ? 585 VAL A N     1 
ATOM   4065 C CA    . VAL A 1 585 ? 125.832 102.773 121.756 1.00 304.34 ? 585 VAL A CA    1 
ATOM   4066 C C     . VAL A 1 585 ? 127.303 103.142 121.657 1.00 304.34 ? 585 VAL A C     1 
ATOM   4067 O O     . VAL A 1 585 ? 127.862 103.251 120.565 1.00 304.34 ? 585 VAL A O     1 
ATOM   4068 C CB    . VAL A 1 585 ? 125.656 101.287 122.162 1.00 304.34 ? 585 VAL A CB    1 
ATOM   4069 C CG1   . VAL A 1 585 ? 126.575 100.392 121.340 1.00 304.34 ? 585 VAL A CG1   1 
ATOM   4070 C CG2   . VAL A 1 585 ? 125.878 101.092 123.658 1.00 304.34 ? 585 VAL A CG2   1 
ATOM   4071 N N     . ASN A 1 586 ? 127.935 103.336 122.813 1.00 290.80 ? 586 ASN A N     1 
ATOM   4072 C CA    . ASN A 1 586 ? 129.378 103.523 122.827 1.00 290.80 ? 586 ASN A CA    1 
ATOM   4073 C C     . ASN A 1 586 ? 130.042 102.287 122.236 1.00 290.80 ? 586 ASN A C     1 
ATOM   4074 O O     . ASN A 1 586 ? 129.545 101.168 122.385 1.00 290.80 ? 586 ASN A O     1 
ATOM   4075 C CB    . ASN A 1 586 ? 129.873 103.766 124.251 1.00 290.80 ? 586 ASN A CB    1 
ATOM   4076 C CG    . ASN A 1 586 ? 131.256 104.381 124.289 1.00 290.80 ? 586 ASN A CG    1 
ATOM   4077 O OD1   . ASN A 1 586 ? 132.263 103.680 124.187 1.00 290.80 ? 586 ASN A OD1   1 
ATOM   4078 N ND2   . ASN A 1 586 ? 131.315 105.700 124.435 1.00 290.80 ? 586 ASN A ND2   1 
ATOM   4079 N N     . LYS A 1 587 ? 131.174 102.496 121.561 1.00 268.01 ? 587 LYS A N     1 
ATOM   4080 C CA    . LYS A 1 587 ? 131.816 101.400 120.848 1.00 268.01 ? 587 LYS A CA    1 
ATOM   4081 C C     . LYS A 1 587 ? 132.291 100.287 121.771 1.00 268.01 ? 587 LYS A C     1 
ATOM   4082 O O     . LYS A 1 587 ? 132.302 99.118  121.370 1.00 268.01 ? 587 LYS A O     1 
ATOM   4083 C CB    . LYS A 1 587 ? 132.989 101.942 120.028 1.00 268.01 ? 587 LYS A CB    1 
ATOM   4084 C CG    . LYS A 1 587 ? 133.635 100.923 119.106 1.00 268.01 ? 587 LYS A CG    1 
ATOM   4085 C CD    . LYS A 1 587 ? 134.806 101.531 118.354 1.00 268.01 ? 587 LYS A CD    1 
ATOM   4086 C CE    . LYS A 1 587 ? 135.489 100.502 117.471 1.00 268.01 ? 587 LYS A CE    1 
ATOM   4087 N NZ    . LYS A 1 587 ? 136.633 101.091 116.721 1.00 268.01 ? 587 LYS A NZ    1 
ATOM   4088 N N     . LYS A 1 588 ? 132.547 100.590 123.044 1.00 277.89 ? 588 LYS A N     1 
ATOM   4089 C CA    . LYS A 1 588 ? 133.075 99.539  123.904 1.00 277.89 ? 588 LYS A CA    1 
ATOM   4090 C C     . LYS A 1 588 ? 132.015 98.531  124.315 1.00 277.89 ? 588 LYS A C     1 
ATOM   4091 O O     . LYS A 1 588 ? 132.354 97.372  124.577 1.00 277.89 ? 588 LYS A O     1 
ATOM   4092 C CB    . LYS A 1 588 ? 133.725 100.169 125.137 1.00 277.89 ? 588 LYS A CB    1 
ATOM   4093 C CG    . LYS A 1 588 ? 132.771 100.990 125.990 1.00 277.89 ? 588 LYS A CG    1 
ATOM   4094 C CD    . LYS A 1 588 ? 133.520 101.757 127.068 1.00 277.89 ? 588 LYS A CD    1 
ATOM   4095 C CE    . LYS A 1 588 ? 132.596 102.705 127.812 1.00 277.89 ? 588 LYS A CE    1 
ATOM   4096 N NZ    . LYS A 1 588 ? 133.330 103.529 128.813 1.00 277.89 ? 588 LYS A NZ    1 
ATOM   4097 N N     . PHE A 1 589 ? 130.745 98.927  124.375 1.00 298.87 ? 589 PHE A N     1 
ATOM   4098 C CA    . PHE A 1 589 ? 129.678 97.969  124.607 1.00 298.87 ? 589 PHE A CA    1 
ATOM   4099 C C     . PHE A 1 589 ? 129.127 97.405  123.304 1.00 298.87 ? 589 PHE A C     1 
ATOM   4100 O O     . PHE A 1 589 ? 128.093 96.722  123.330 1.00 298.87 ? 589 PHE A O     1 
ATOM   4101 C CB    . PHE A 1 589 ? 128.548 98.615  125.407 1.00 298.87 ? 589 PHE A CB    1 
ATOM   4102 C CG    . PHE A 1 589 ? 129.002 99.286  126.668 1.00 298.87 ? 589 PHE A CG    1 
ATOM   4103 C CD1   . PHE A 1 589 ? 129.461 98.542  127.742 1.00 298.87 ? 589 PHE A CD1   1 
ATOM   4104 C CD2   . PHE A 1 589 ? 128.963 100.666 126.784 1.00 298.87 ? 589 PHE A CD2   1 
ATOM   4105 C CE1   . PHE A 1 589 ? 129.877 99.163  128.904 1.00 298.87 ? 589 PHE A CE1   1 
ATOM   4106 C CE2   . PHE A 1 589 ? 129.376 101.292 127.943 1.00 298.87 ? 589 PHE A CE2   1 
ATOM   4107 C CZ    . PHE A 1 589 ? 129.833 100.540 129.006 1.00 298.87 ? 589 PHE A CZ    1 
ATOM   4108 N N     . GLN A 1 590 ? 129.853 97.576  122.188 1.00 293.72 ? 590 GLN A N     1 
ATOM   4109 C CA    . GLN A 1 590 ? 129.285 97.205  120.890 1.00 293.72 ? 590 GLN A CA    1 
ATOM   4110 C C     . GLN A 1 590 ? 128.771 95.772  120.884 1.00 293.72 ? 590 GLN A C     1 
ATOM   4111 O O     . GLN A 1 590 ? 127.556 95.545  120.784 1.00 293.72 ? 590 GLN A O     1 
ATOM   4112 C CB    . GLN A 1 590 ? 130.309 97.432  119.770 1.00 293.72 ? 590 GLN A CB    1 
ATOM   4113 C CG    . GLN A 1 590 ? 131.612 96.638  119.850 1.00 293.72 ? 590 GLN A CG    1 
ATOM   4114 C CD    . GLN A 1 590 ? 132.463 96.795  118.606 1.00 293.72 ? 590 GLN A CD    1 
ATOM   4115 O OE1   . GLN A 1 590 ? 131.955 97.093  117.527 1.00 293.72 ? 590 GLN A OE1   1 
ATOM   4116 N NE2   . GLN A 1 590 ? 133.767 96.594  118.754 1.00 293.72 ? 590 GLN A NE2   1 
ATOM   4117 N N     . GLU A 1 591 ? 129.653 94.804  121.120 1.00 285.19 ? 591 GLU A N     1 
ATOM   4118 C CA    . GLU A 1 591 ? 129.235 93.415  121.014 1.00 285.19 ? 591 GLU A CA    1 
ATOM   4119 C C     . GLU A 1 591 ? 128.238 93.070  122.103 1.00 285.19 ? 591 GLU A C     1 
ATOM   4120 O O     . GLU A 1 591 ? 127.257 92.359  121.846 1.00 285.19 ? 591 GLU A O     1 
ATOM   4121 C CB    . GLU A 1 591 ? 130.453 92.493  121.092 1.00 285.19 ? 591 GLU A CB    1 
ATOM   4122 C CG    . GLU A 1 591 ? 131.477 92.678  119.978 1.00 285.19 ? 591 GLU A CG    1 
ATOM   4123 C CD    . GLU A 1 591 ? 130.942 92.336  118.599 1.00 285.19 ? 591 GLU A CD    1 
ATOM   4124 O OE1   . GLU A 1 591 ? 129.860 91.718  118.501 1.00 285.19 ? 591 GLU A OE1   1 
ATOM   4125 O OE2   . GLU A 1 591 ? 131.616 92.678  117.606 1.00 285.19 ? 591 GLU A OE2   1 
ATOM   4126 N N     . GLU A 1 592 ? 128.352 93.722  123.264 1.00 280.31 ? 592 GLU A N     1 
ATOM   4127 C CA    . GLU A 1 592 ? 127.404 93.418  124.323 1.00 280.31 ? 592 GLU A CA    1 
ATOM   4128 C C     . GLU A 1 592 ? 126.026 93.913  123.940 1.00 280.31 ? 592 GLU A C     1 
ATOM   4129 O O     . GLU A 1 592 ? 125.035 93.183  124.091 1.00 280.31 ? 592 GLU A O     1 
ATOM   4130 C CB    . GLU A 1 592 ? 127.856 94.051  125.638 1.00 280.31 ? 592 GLU A CB    1 
ATOM   4131 C CG    . GLU A 1 592 ? 126.967 93.713  126.823 1.00 280.31 ? 592 GLU A CG    1 
ATOM   4132 C CD    . GLU A 1 592 ? 127.472 94.313  128.120 1.00 280.31 ? 592 GLU A CD    1 
ATOM   4133 O OE1   . GLU A 1 592 ? 128.606 94.837  128.132 1.00 280.31 ? 592 GLU A OE1   1 
ATOM   4134 O OE2   . GLU A 1 592 ? 126.735 94.262  129.127 1.00 280.31 ? 592 GLU A OE2   1 
ATOM   4135 N N     . ALA A 1 593 ? 125.958 95.068  123.285 1.00 273.70 ? 593 ALA A N     1 
ATOM   4136 C CA    . ALA A 1 593 ? 124.644 95.544  122.904 1.00 273.70 ? 593 ALA A CA    1 
ATOM   4137 C C     . ALA A 1 593 ? 124.123 94.693  121.764 1.00 273.70 ? 593 ALA A C     1 
ATOM   4138 O O     . ALA A 1 593 ? 122.928 94.376  121.711 1.00 273.70 ? 593 ALA A O     1 
ATOM   4139 C CB    . ALA A 1 593 ? 124.701 97.019  122.512 1.00 273.70 ? 593 ALA A CB    1 
ATOM   4140 N N     . LEU A 1 594 ? 125.036 94.219  120.909 1.00 256.83 ? 594 LEU A N     1 
ATOM   4141 C CA    . LEU A 1 594 ? 124.639 93.288  119.865 1.00 256.83 ? 594 LEU A CA    1 
ATOM   4142 C C     . LEU A 1 594 ? 123.919 92.091  120.462 1.00 256.83 ? 594 LEU A C     1 
ATOM   4143 O O     . LEU A 1 594 ? 122.775 91.799  120.082 1.00 256.83 ? 594 LEU A O     1 
ATOM   4144 C CB    . LEU A 1 594 ? 125.870 92.846  119.070 1.00 256.83 ? 594 LEU A CB    1 
ATOM   4145 C CG    . LEU A 1 594 ? 125.656 92.114  117.742 1.00 256.83 ? 594 LEU A CG    1 
ATOM   4146 C CD1   . LEU A 1 594 ? 126.777 92.449  116.774 1.00 256.83 ? 594 LEU A CD1   1 
ATOM   4147 C CD2   . LEU A 1 594 ? 125.577 90.608  117.954 1.00 256.83 ? 594 LEU A CD2   1 
ATOM   4148 N N     . LYS A 1 595 ? 124.422 91.595  121.594 1.00 259.49 ? 595 LYS A N     1 
ATOM   4149 C CA    . LYS A 1 595 ? 123.782 90.420  122.163 1.00 259.49 ? 595 LYS A CA    1 
ATOM   4150 C C     . LYS A 1 595 ? 122.480 90.835  122.798 1.00 259.49 ? 595 LYS A C     1 
ATOM   4151 O O     . LYS A 1 595 ? 121.442 90.190  122.585 1.00 259.49 ? 595 LYS A O     1 
ATOM   4152 C CB    . LYS A 1 595 ? 124.701 89.754  123.186 1.00 259.49 ? 595 LYS A CB    1 
ATOM   4153 C CG    . LYS A 1 595 ? 125.918 89.084  122.579 1.00 259.49 ? 595 LYS A CG    1 
ATOM   4154 C CD    . LYS A 1 595 ? 126.717 88.342  123.635 1.00 259.49 ? 595 LYS A CD    1 
ATOM   4155 C CE    . LYS A 1 595 ? 127.945 87.681  123.034 1.00 259.49 ? 595 LYS A CE    1 
ATOM   4156 N NZ    . LYS A 1 595 ? 128.786 87.029  124.075 1.00 259.49 ? 595 LYS A NZ    1 
ATOM   4157 N N     . ILE A 1 596 ? 122.488 91.984  123.465 1.00 251.32 ? 596 ILE A N     1 
ATOM   4158 C CA    . ILE A 1 596 ? 121.263 92.462  124.072 1.00 251.32 ? 596 ILE A CA    1 
ATOM   4159 C C     . ILE A 1 596 ? 120.216 92.597  122.985 1.00 251.32 ? 596 ILE A C     1 
ATOM   4160 O O     . ILE A 1 596 ? 119.128 92.009  123.072 1.00 251.32 ? 596 ILE A O     1 
ATOM   4161 C CB    . ILE A 1 596 ? 121.511 93.797  124.798 1.00 251.32 ? 596 ILE A CB    1 
ATOM   4162 C CG1   . ILE A 1 596 ? 122.343 93.572  126.064 1.00 251.32 ? 596 ILE A CG1   1 
ATOM   4163 C CG2   . ILE A 1 596 ? 120.203 94.509  125.073 1.00 251.32 ? 596 ILE A CG2   1 
ATOM   4164 C CD1   . ILE A 1 596 ? 122.975 94.831  126.609 1.00 251.32 ? 596 ILE A CD1   1 
ATOM   4165 N N     . LEU A 1 597 ? 120.612 93.198  121.861 1.00 268.71 ? 597 LEU A N     1 
ATOM   4166 C CA    . LEU A 1 597 ? 119.648 93.426  120.797 1.00 268.71 ? 597 LEU A CA    1 
ATOM   4167 C C     . LEU A 1 597 ? 119.138 92.101  120.270 1.00 268.71 ? 597 LEU A C     1 
ATOM   4168 O O     . LEU A 1 597 ? 117.921 91.875  120.207 1.00 268.71 ? 597 LEU A O     1 
ATOM   4169 C CB    . LEU A 1 597 ? 120.300 94.265  119.697 1.00 268.71 ? 597 LEU A CB    1 
ATOM   4170 C CG    . LEU A 1 597 ? 119.491 94.726  118.491 1.00 268.71 ? 597 LEU A CG    1 
ATOM   4171 C CD1   . LEU A 1 597 ? 118.354 95.617  118.918 1.00 268.71 ? 597 LEU A CD1   1 
ATOM   4172 C CD2   . LEU A 1 597 ? 120.425 95.500  117.586 1.00 268.71 ? 597 LEU A CD2   1 
ATOM   4173 N N     . VAL A 1 598 ? 120.045 91.144  120.085 1.00 221.50 ? 598 VAL A N     1 
ATOM   4174 C CA    . VAL A 1 598 ? 119.624 89.864  119.538 1.00 221.50 ? 598 VAL A CA    1 
ATOM   4175 C C     . VAL A 1 598 ? 118.686 89.193  120.521 1.00 221.50 ? 598 VAL A C     1 
ATOM   4176 O O     . VAL A 1 598 ? 117.572 88.781  120.166 1.00 221.50 ? 598 VAL A O     1 
ATOM   4177 C CB    . VAL A 1 598 ? 120.845 88.982  119.220 1.00 221.50 ? 598 VAL A CB    1 
ATOM   4178 C CG1   . VAL A 1 598 ? 120.402 87.567  118.886 1.00 221.50 ? 598 VAL A CG1   1 
ATOM   4179 C CG2   . VAL A 1 598 ? 121.642 89.575  118.071 1.00 221.50 ? 598 VAL A CG2   1 
ATOM   4180 N N     . GLN A 1 599 ? 119.043 89.239  121.802 1.00 190.73 ? 599 GLN A N     1 
ATOM   4181 C CA    . GLN A 1 599 ? 118.222 88.551  122.779 1.00 190.73 ? 599 GLN A CA    1 
ATOM   4182 C C     . GLN A 1 599 ? 116.928 89.311  122.994 1.00 190.73 ? 599 GLN A C     1 
ATOM   4183 O O     . GLN A 1 599 ? 115.896 88.714  123.322 1.00 190.73 ? 599 GLN A O     1 
ATOM   4184 C CB    . GLN A 1 599 ? 118.987 88.387  124.090 1.00 190.73 ? 599 GLN A CB    1 
ATOM   4185 C CG    . GLN A 1 599 ? 118.360 87.397  125.055 1.00 190.73 ? 599 GLN A CG    1 
ATOM   4186 C CD    . GLN A 1 599 ? 118.523 85.954  124.609 1.00 190.73 ? 599 GLN A CD    1 
ATOM   4187 O OE1   . GLN A 1 599 ? 119.136 85.672  123.579 1.00 190.73 ? 599 GLN A OE1   1 
ATOM   4188 N NE2   . GLN A 1 599 ? 117.968 85.032  125.387 1.00 190.73 ? 599 GLN A NE2   1 
ATOM   4189 N N     . SER A 1 600 ? 116.962 90.633  122.822 1.00 231.57 ? 600 SER A N     1 
ATOM   4190 C CA    . SER A 1 600 ? 115.721 91.382  122.903 1.00 231.57 ? 600 SER A CA    1 
ATOM   4191 C C     . SER A 1 600 ? 114.752 90.955  121.807 1.00 231.57 ? 600 SER A C     1 
ATOM   4192 O O     . SER A 1 600 ? 113.540 90.855  122.036 1.00 231.57 ? 600 SER A O     1 
ATOM   4193 C CB    . SER A 1 600 ? 116.012 92.880  122.817 1.00 231.57 ? 600 SER A CB    1 
ATOM   4194 O OG    . SER A 1 600 ? 116.634 93.331  124.005 1.00 231.57 ? 600 SER A OG    1 
ATOM   4195 N N     . MET A 1 601 ? 115.272 90.693  120.606 1.00 276.80 ? 601 MET A N     1 
ATOM   4196 C CA    . MET A 1 601 ? 114.396 90.285  119.512 1.00 276.80 ? 601 MET A CA    1 
ATOM   4197 C C     . MET A 1 601 ? 114.026 88.808  119.571 1.00 276.80 ? 601 MET A C     1 
ATOM   4198 O O     . MET A 1 601 ? 112.842 88.454  119.480 1.00 276.80 ? 601 MET A O     1 
ATOM   4199 C CB    . MET A 1 601 ? 115.061 90.619  118.176 1.00 276.80 ? 601 MET A CB    1 
ATOM   4200 C CG    . MET A 1 601 ? 115.202 92.112  117.923 1.00 276.80 ? 601 MET A CG    1 
ATOM   4201 S SD    . MET A 1 601 ? 116.285 92.511  116.537 1.00 276.80 ? 601 MET A SD    1 
ATOM   4202 C CE    . MET A 1 601 ? 115.328 91.920  115.143 1.00 276.80 ? 601 MET A CE    1 
ATOM   4203 N N     . GLU A 1 602 ? 114.989 87.957  119.937 1.00 243.63 ? 602 GLU A N     1 
ATOM   4204 C CA    . GLU A 1 602 ? 114.705 86.528  120.017 1.00 243.63 ? 602 GLU A CA    1 
ATOM   4205 C C     . GLU A 1 602 ? 113.676 86.215  121.087 1.00 243.63 ? 602 GLU A C     1 
ATOM   4206 O O     . GLU A 1 602 ? 112.685 85.527  120.807 1.00 243.63 ? 602 GLU A O     1 
ATOM   4207 C CB    . GLU A 1 602 ? 116.000 85.763  120.281 1.00 243.63 ? 602 GLU A CB    1 
ATOM   4208 C CG    . GLU A 1 602 ? 116.935 85.705  119.084 1.00 243.63 ? 602 GLU A CG    1 
ATOM   4209 C CD    . GLU A 1 602 ? 118.183 84.891  119.358 1.00 243.63 ? 602 GLU A CD    1 
ATOM   4210 O OE1   . GLU A 1 602 ? 118.556 84.754  120.542 1.00 243.63 ? 602 GLU A OE1   1 
ATOM   4211 O OE2   . GLU A 1 602 ? 118.795 84.394  118.389 1.00 243.63 ? 602 GLU A OE2   1 
ATOM   4212 N N     . ASN A 1 603 ? 113.812 86.812  122.269 1.00 223.24 ? 603 ASN A N     1 
ATOM   4213 C CA    . ASN A 1 603 ? 112.837 86.518  123.306 1.00 223.24 ? 603 ASN A CA    1 
ATOM   4214 C C     . ASN A 1 603 ? 111.467 86.988  122.859 1.00 223.24 ? 603 ASN A C     1 
ATOM   4215 O O     . ASN A 1 603 ? 110.475 86.264  123.011 1.00 223.24 ? 603 ASN A O     1 
ATOM   4216 C CB    . ASN A 1 603 ? 113.241 87.188  124.617 1.00 223.24 ? 603 ASN A CB    1 
ATOM   4217 C CG    . ASN A 1 603 ? 114.503 86.600  125.208 1.00 223.24 ? 603 ASN A CG    1 
ATOM   4218 O OD1   . ASN A 1 603 ? 114.842 85.443  124.951 1.00 223.24 ? 603 ASN A OD1   1 
ATOM   4219 N ND2   . ASN A 1 603 ? 115.207 87.392  126.005 1.00 223.24 ? 603 ASN A ND2   1 
ATOM   4220 N N     . SER A 1 604 ? 111.423 88.129  122.165 1.00 223.71 ? 604 SER A N     1 
ATOM   4221 C CA    . SER A 1 604 ? 110.149 88.604  121.648 1.00 223.71 ? 604 SER A CA    1 
ATOM   4222 C C     . SER A 1 604 ? 109.568 87.584  120.688 1.00 223.71 ? 604 SER A C     1 
ATOM   4223 O O     . SER A 1 604 ? 108.405 87.184  120.821 1.00 223.71 ? 604 SER A O     1 
ATOM   4224 C CB    . SER A 1 604 ? 110.327 89.961  120.979 1.00 223.71 ? 604 SER A CB    1 
ATOM   4225 O OG    . SER A 1 604 ? 110.764 90.902  121.937 1.00 223.71 ? 604 SER A OG    1 
ATOM   4226 N N     . ALA A 1 605 ? 110.376 87.131  119.728 1.00 278.39 ? 605 ALA A N     1 
ATOM   4227 C CA    . ALA A 1 605 ? 109.894 86.117  118.805 1.00 278.39 ? 605 ALA A CA    1 
ATOM   4228 C C     . ALA A 1 605 ? 109.466 84.870  119.562 1.00 278.39 ? 605 ALA A C     1 
ATOM   4229 O O     . ALA A 1 605 ? 108.405 84.296  119.280 1.00 278.39 ? 605 ALA A O     1 
ATOM   4230 C CB    . ALA A 1 605 ? 110.975 85.781  117.778 1.00 278.39 ? 605 ALA A CB    1 
ATOM   4231 N N     . SER A 1 606 ? 110.238 84.487  120.586 1.00 279.57 ? 606 SER A N     1 
ATOM   4232 C CA    . SER A 1 606 ? 109.870 83.308  121.358 1.00 279.57 ? 606 SER A CA    1 
ATOM   4233 C C     . SER A 1 606 ? 108.515 83.476  122.019 1.00 279.57 ? 606 SER A C     1 
ATOM   4234 O O     . SER A 1 606 ? 107.796 82.489  122.213 1.00 279.57 ? 606 SER A O     1 
ATOM   4235 C CB    . SER A 1 606 ? 110.940 83.016  122.410 1.00 279.57 ? 606 SER A CB    1 
ATOM   4236 O OG    . SER A 1 606 ? 112.171 82.666  121.802 1.00 279.57 ? 606 SER A OG    1 
ATOM   4237 N N     . TYR A 1 607 ? 108.119 84.719  122.300 1.00 266.24 ? 607 TYR A N     1 
ATOM   4238 C CA    . TYR A 1 607 ? 106.820 84.893  122.994 1.00 266.24 ? 607 TYR A CA    1 
ATOM   4239 C C     . TYR A 1 607 ? 105.683 84.557  122.027 1.00 266.24 ? 607 TYR A C     1 
ATOM   4240 O O     . TYR A 1 607 ? 104.645 84.045  122.490 1.00 266.24 ? 607 TYR A O     1 
ATOM   4241 C CB    . TYR A 1 607 ? 106.582 86.316  123.495 1.00 266.24 ? 607 TYR A CB    1 
ATOM   4242 C CG    . TYR A 1 607 ? 105.201 86.551  124.049 1.00 266.24 ? 607 TYR A CG    1 
ATOM   4243 C CD1   . TYR A 1 607 ? 104.808 85.981  125.247 1.00 266.24 ? 607 TYR A CD1   1 
ATOM   4244 C CD2   . TYR A 1 607 ? 104.280 87.329  123.369 1.00 266.24 ? 607 TYR A CD2   1 
ATOM   4245 C CE1   . TYR A 1 607 ? 103.540 86.185  125.763 1.00 266.24 ? 607 TYR A CE1   1 
ATOM   4246 C CE2   . TYR A 1 607 ? 103.007 87.543  123.869 1.00 266.24 ? 607 TYR A CE2   1 
ATOM   4247 C CZ    . TYR A 1 607 ? 102.635 86.969  125.071 1.00 266.24 ? 607 TYR A CZ    1 
ATOM   4248 O OH    . TYR A 1 607 ? 101.384 87.172  125.576 1.00 266.24 ? 607 TYR A OH    1 
ATOM   4249 N N     . PHE A 1 608 ? 105.866 84.828  120.730 1.00 225.55 ? 608 PHE A N     1 
ATOM   4250 C CA    . PHE A 1 608 ? 104.764 84.631  119.794 1.00 225.55 ? 608 PHE A CA    1 
ATOM   4251 C C     . PHE A 1 608 ? 104.856 83.366  118.955 1.00 225.55 ? 608 PHE A C     1 
ATOM   4252 O O     . PHE A 1 608 ? 103.820 82.771  118.641 1.00 225.55 ? 608 PHE A O     1 
ATOM   4253 C CB    . PHE A 1 608 ? 104.649 85.834  118.856 1.00 225.55 ? 608 PHE A CB    1 
ATOM   4254 C CG    . PHE A 1 608 ? 104.310 87.112  119.552 1.00 225.55 ? 608 PHE A CG    1 
ATOM   4255 C CD1   . PHE A 1 608 ? 103.007 87.372  119.943 1.00 225.55 ? 608 PHE A CD1   1 
ATOM   4256 C CD2   . PHE A 1 608 ? 105.288 88.051  119.821 1.00 225.55 ? 608 PHE A CD2   1 
ATOM   4257 C CE1   . PHE A 1 608 ? 102.686 88.546  120.583 1.00 225.55 ? 608 PHE A CE1   1 
ATOM   4258 C CE2   . PHE A 1 608 ? 104.972 89.228  120.463 1.00 225.55 ? 608 PHE A CE2   1 
ATOM   4259 C CZ    . PHE A 1 608 ? 103.668 89.475  120.843 1.00 225.55 ? 608 PHE A CZ    1 
ATOM   4260 N N     . LEU A 1 609 ? 106.052 82.929  118.578 1.00 374.99 ? 609 LEU A N     1 
ATOM   4261 C CA    . LEU A 1 609 ? 106.191 81.795  117.668 1.00 374.99 ? 609 LEU A CA    1 
ATOM   4262 C C     . LEU A 1 609 ? 106.629 80.568  118.456 1.00 374.99 ? 609 LEU A C     1 
ATOM   4263 O O     . LEU A 1 609 ? 107.675 80.573  119.111 1.00 374.99 ? 609 LEU A O     1 
ATOM   4264 C CB    . LEU A 1 609 ? 107.174 82.126  116.551 1.00 374.99 ? 609 LEU A CB    1 
ATOM   4265 C CG    . LEU A 1 609 ? 106.784 83.334  115.697 1.00 374.99 ? 609 LEU A CG    1 
ATOM   4266 C CD1   . LEU A 1 609 ? 107.893 83.688  114.724 1.00 374.99 ? 609 LEU A CD1   1 
ATOM   4267 C CD2   . LEU A 1 609 ? 105.475 83.099  114.962 1.00 374.99 ? 609 LEU A CD2   1 
ATOM   4268 N N     . LYS A 1 610 ? 105.817 79.514  118.389 1.00 391.21 ? 610 LYS A N     1 
ATOM   4269 C CA    . LYS A 1 610 ? 106.095 78.286  119.117 1.00 391.21 ? 610 LYS A CA    1 
ATOM   4270 C C     . LYS A 1 610 ? 106.543 77.153  118.207 1.00 391.21 ? 610 LYS A C     1 
ATOM   4271 O O     . LYS A 1 610 ? 107.088 76.159  118.702 1.00 391.21 ? 610 LYS A O     1 
ATOM   4272 C CB    . LYS A 1 610 ? 104.851 77.847  119.895 1.00 391.21 ? 610 LYS A CB    1 
ATOM   4273 C CG    . LYS A 1 610 ? 104.265 78.934  120.783 1.00 391.21 ? 610 LYS A CG    1 
ATOM   4274 C CD    . LYS A 1 610 ? 105.250 79.398  121.842 1.00 391.21 ? 610 LYS A CD    1 
ATOM   4275 C CE    . LYS A 1 610 ? 104.793 80.704  122.469 1.00 391.21 ? 610 LYS A CE    1 
ATOM   4276 N NZ    . LYS A 1 610 ? 105.785 81.242  123.438 1.00 391.21 ? 610 LYS A NZ    1 
ATOM   4277 N N     . LYS A 1 611 ? 106.328 77.276  116.896 1.00 415.64 ? 611 LYS A N     1 
ATOM   4278 C CA    . LYS A 1 611 ? 106.624 76.206  115.955 1.00 415.64 ? 611 LYS A CA    1 
ATOM   4279 C C     . LYS A 1 611 ? 107.702 76.551  114.938 1.00 415.64 ? 611 LYS A C     1 
ATOM   4280 O O     . LYS A 1 611 ? 107.993 75.720  114.069 1.00 415.64 ? 611 LYS A O     1 
ATOM   4281 C CB    . LYS A 1 611 ? 105.343 75.814  115.201 1.00 415.64 ? 611 LYS A CB    1 
ATOM   4282 C CG    . LYS A 1 611 ? 104.258 75.209  116.075 1.00 415.64 ? 611 LYS A CG    1 
ATOM   4283 C CD    . LYS A 1 611 ? 103.020 74.870  115.258 1.00 415.64 ? 611 LYS A CD    1 
ATOM   4284 C CE    . LYS A 1 611 ? 102.008 74.086  116.076 1.00 415.64 ? 611 LYS A CE    1 
ATOM   4285 N NZ    . LYS A 1 611 ? 100.834 73.671  115.260 1.00 415.64 ? 611 LYS A NZ    1 
ATOM   4286 N N     . VAL A 1 612 ? 108.302 77.736  115.009 1.00 404.31 ? 612 VAL A N     1 
ATOM   4287 C CA    . VAL A 1 612 ? 109.305 78.165  114.042 1.00 404.31 ? 612 VAL A CA    1 
ATOM   4288 C C     . VAL A 1 612 ? 110.269 79.140  114.705 1.00 404.31 ? 612 VAL A C     1 
ATOM   4289 O O     . VAL A 1 612 ? 109.871 79.940  115.558 1.00 404.31 ? 612 VAL A O     1 
ATOM   4290 C CB    . VAL A 1 612 ? 108.644 78.798  112.796 1.00 404.31 ? 612 VAL A CB    1 
ATOM   4291 C CG1   . VAL A 1 612 ? 107.896 80.073  113.162 1.00 404.31 ? 612 VAL A CG1   1 
ATOM   4292 C CG2   . VAL A 1 612 ? 109.676 79.061  111.708 1.00 404.31 ? 612 VAL A CG2   1 
ATOM   4293 N N     . LYS A 1 613 ? 111.547 79.051  114.336 1.00 477.09 ? 613 LYS A N     1 
ATOM   4294 C CA    . LYS A 1 613 ? 112.562 79.903  114.945 1.00 477.09 ? 613 LYS A CA    1 
ATOM   4295 C C     . LYS A 1 613 ? 112.956 81.011  113.975 1.00 477.09 ? 613 LYS A C     1 
ATOM   4296 O O     . LYS A 1 613 ? 113.190 80.759  112.789 1.00 477.09 ? 613 LYS A O     1 
ATOM   4297 C CB    . LYS A 1 613 ? 113.791 79.079  115.326 1.00 477.09 ? 613 LYS A CB    1 
ATOM   4298 C CG    . LYS A 1 613 ? 115.052 79.914  115.509 1.00 477.09 ? 613 LYS A CG    1 
ATOM   4299 C CD    . LYS A 1 613 ? 116.284 79.060  115.756 1.00 477.09 ? 613 LYS A CD    1 
ATOM   4300 C CE    . LYS A 1 613 ? 117.510 79.934  115.986 1.00 477.09 ? 613 LYS A CE    1 
ATOM   4301 N NZ    . LYS A 1 613 ? 118.744 79.133  116.216 1.00 477.09 ? 613 LYS A NZ    1 
ATOM   4302 N N     . CYS A 1 614 ? 113.030 82.240  114.482 1.00 506.42 ? 614 CYS A N     1 
ATOM   4303 C CA    . CYS A 1 614 ? 113.414 83.404  113.694 1.00 506.42 ? 614 CYS A CA    1 
ATOM   4304 C C     . CYS A 1 614 ? 114.921 83.454  113.488 1.00 506.42 ? 614 CYS A C     1 
ATOM   4305 O O     . CYS A 1 614 ? 115.672 82.737  114.156 1.00 506.42 ? 614 CYS A O     1 
ATOM   4306 C CB    . CYS A 1 614 ? 112.939 84.695  114.362 1.00 506.42 ? 614 CYS A CB    1 
ATOM   4307 S SG    . CYS A 1 614 ? 111.155 84.934  114.306 1.00 506.42 ? 614 CYS A SG    1 
ATOM   4308 N N     . GLU A 1 615 ? 115.348 84.311  112.564 1.00 375.35 ? 615 GLU A N     1 
ATOM   4309 C CA    . GLU A 1 615 ? 116.746 84.597  112.288 1.00 375.35 ? 615 GLU A CA    1 
ATOM   4310 C C     . GLU A 1 615 ? 116.959 86.107  112.296 1.00 375.35 ? 615 GLU A C     1 
ATOM   4311 O O     . GLU A 1 615 ? 116.284 86.850  111.580 1.00 375.35 ? 615 GLU A O     1 
ATOM   4312 C CB    . GLU A 1 615 ? 117.200 83.999  110.952 1.00 375.35 ? 615 GLU A CB    1 
ATOM   4313 C CG    . GLU A 1 615 ? 117.646 82.548  111.046 1.00 375.35 ? 615 GLU A CG    1 
ATOM   4314 C CD    . GLU A 1 615 ? 117.946 81.941  109.687 1.00 375.35 ? 615 GLU A CD    1 
ATOM   4315 O OE1   . GLU A 1 615 ? 117.726 82.628  108.668 1.00 375.35 ? 615 GLU A OE1   1 
ATOM   4316 O OE2   . GLU A 1 615 ? 118.404 80.780  109.642 1.00 375.35 ? 615 GLU A OE2   1 
ATOM   4317 N N     . VAL A 1 616 ? 117.905 86.556  113.114 1.00 339.62 ? 616 VAL A N     1 
ATOM   4318 C CA    . VAL A 1 616 ? 118.221 87.974  113.250 1.00 339.62 ? 616 VAL A CA    1 
ATOM   4319 C C     . VAL A 1 616 ? 119.538 88.251  112.540 1.00 339.62 ? 616 VAL A C     1 
ATOM   4320 O O     . VAL A 1 616 ? 120.571 87.659  112.879 1.00 339.62 ? 616 VAL A O     1 
ATOM   4321 C CB    . VAL A 1 616 ? 118.301 88.400  114.727 1.00 339.62 ? 616 VAL A CB    1 
ATOM   4322 C CG1   . VAL A 1 616 ? 118.629 89.882  114.832 1.00 339.62 ? 616 VAL A CG1   1 
ATOM   4323 C CG2   . VAL A 1 616 ? 116.997 88.083  115.441 1.00 339.62 ? 616 VAL A CG2   1 
ATOM   4324 N N     . SER A 1 617 ? 119.498 89.149  111.559 1.00 316.51 ? 617 SER A N     1 
ATOM   4325 C CA    . SER A 1 617 ? 120.707 89.662  110.928 1.00 316.51 ? 617 SER A CA    1 
ATOM   4326 C C     . SER A 1 617 ? 121.117 90.970  111.591 1.00 316.51 ? 617 SER A C     1 
ATOM   4327 O O     . SER A 1 617 ? 120.335 91.922  111.629 1.00 316.51 ? 617 SER A O     1 
ATOM   4328 C CB    . SER A 1 617 ? 120.483 89.879  109.432 1.00 316.51 ? 617 SER A CB    1 
ATOM   4329 O OG    . SER A 1 617 ? 119.428 90.795  109.203 1.00 316.51 ? 617 SER A OG    1 
ATOM   4330 N N     . VAL A 1 618 ? 122.349 91.022  112.091 1.00 324.76 ? 618 VAL A N     1 
ATOM   4331 C CA    . VAL A 1 618 ? 122.820 92.161  112.865 1.00 324.76 ? 618 VAL A CA    1 
ATOM   4332 C C     . VAL A 1 618 ? 124.188 92.585  112.346 1.00 324.76 ? 618 VAL A C     1 
ATOM   4333 O O     . VAL A 1 618 ? 125.004 91.756  111.928 1.00 324.76 ? 618 VAL A O     1 
ATOM   4334 C CB    . VAL A 1 618 ? 122.872 91.843  114.378 1.00 324.76 ? 618 VAL A CB    1 
ATOM   4335 C CG1   . VAL A 1 618 ? 123.904 90.763  114.672 1.00 324.76 ? 618 VAL A CG1   1 
ATOM   4336 C CG2   . VAL A 1 618 ? 123.146 93.102  115.188 1.00 324.76 ? 618 VAL A CG2   1 
ATOM   4337 N N     . LYS A 1 619 ? 124.423 93.897  112.350 1.00 327.97 ? 619 LYS A N     1 
ATOM   4338 C CA    . LYS A 1 619 ? 125.687 94.457  111.899 1.00 327.97 ? 619 LYS A CA    1 
ATOM   4339 C C     . LYS A 1 619 ? 126.060 95.664  112.747 1.00 327.97 ? 619 LYS A C     1 
ATOM   4340 O O     . LYS A 1 619 ? 125.190 96.391  113.242 1.00 327.97 ? 619 LYS A O     1 
ATOM   4341 C CB    . LYS A 1 619 ? 125.618 94.855  110.417 1.00 327.97 ? 619 LYS A CB    1 
ATOM   4342 C CG    . LYS A 1 619 ? 126.970 95.161  109.790 1.00 327.97 ? 619 LYS A CG    1 
ATOM   4343 C CD    . LYS A 1 619 ? 126.831 95.576  108.335 1.00 327.97 ? 619 LYS A CD    1 
ATOM   4344 C CE    . LYS A 1 619 ? 128.164 96.033  107.769 1.00 327.97 ? 619 LYS A CE    1 
ATOM   4345 N NZ    . LYS A 1 619 ? 128.064 96.398  106.330 1.00 327.97 ? 619 LYS A NZ    1 
ATOM   4346 N N     . ILE A 1 620 ? 127.368 95.864  112.907 1.00 349.34 ? 620 ILE A N     1 
ATOM   4347 C CA    . ILE A 1 620 ? 127.923 97.026  113.588 1.00 349.34 ? 620 ILE A CA    1 
ATOM   4348 C C     . ILE A 1 620 ? 128.368 98.023  112.529 1.00 349.34 ? 620 ILE A C     1 
ATOM   4349 O O     . ILE A 1 620 ? 129.166 97.682  111.648 1.00 349.34 ? 620 ILE A O     1 
ATOM   4350 C CB    . ILE A 1 620 ? 129.106 96.617  114.479 1.00 349.34 ? 620 ILE A CB    1 
ATOM   4351 C CG1   . ILE A 1 620 ? 128.661 95.616  115.547 1.00 349.34 ? 620 ILE A CG1   1 
ATOM   4352 C CG2   . ILE A 1 620 ? 129.742 97.841  115.115 1.00 349.34 ? 620 ILE A CG2   1 
ATOM   4353 C CD1   . ILE A 1 620 ? 129.797 94.851  116.174 1.00 349.34 ? 620 ILE A CD1   1 
ATOM   4354 N N     . ALA A 1 621 ? 127.863 99.254  112.601 1.00 376.42 ? 621 ALA A N     1 
ATOM   4355 C CA    . ALA A 1 621 ? 128.101 100.198 111.520 1.00 376.42 ? 621 ALA A CA    1 
ATOM   4356 C C     . ALA A 1 621 ? 128.395 101.591 112.055 1.00 376.42 ? 621 ALA A C     1 
ATOM   4357 O O     . ALA A 1 621 ? 128.036 101.938 113.186 1.00 376.42 ? 621 ALA A O     1 
ATOM   4358 C CB    . ALA A 1 621 ? 126.899 100.258 110.571 1.00 376.42 ? 621 ALA A CB    1 
ATOM   4359 N N     . GLU A 1 622 ? 129.114 102.370 111.242 1.00 423.87 ? 622 GLU A N     1 
ATOM   4360 C CA    . GLU A 1 622 ? 129.333 103.780 111.524 1.00 423.87 ? 622 GLU A CA    1 
ATOM   4361 C C     . GLU A 1 622 ? 128.400 104.680 110.725 1.00 423.87 ? 622 GLU A C     1 
ATOM   4362 O O     . GLU A 1 622 ? 128.463 105.905 110.872 1.00 423.87 ? 622 GLU A O     1 
ATOM   4363 C CB    . GLU A 1 622 ? 130.786 104.161 111.226 1.00 423.87 ? 622 GLU A CB    1 
ATOM   4364 C CG    . GLU A 1 622 ? 131.792 103.593 112.212 1.00 423.87 ? 622 GLU A CG    1 
ATOM   4365 C CD    . GLU A 1 622 ? 133.141 104.276 112.123 1.00 423.87 ? 622 GLU A CD    1 
ATOM   4366 O OE1   . GLU A 1 622 ? 133.402 104.946 111.102 1.00 423.87 ? 622 GLU A OE1   1 
ATOM   4367 O OE2   . GLU A 1 622 ? 133.940 104.144 113.074 1.00 423.87 ? 622 GLU A OE2   1 
ATOM   4368 N N     . ASN A 1 623 ? 127.577 104.102 109.853 1.00 414.08 ? 623 ASN A N     1 
ATOM   4369 C CA    . ASN A 1 623 ? 126.572 104.833 109.094 1.00 414.08 ? 623 ASN A CA    1 
ATOM   4370 C C     . ASN A 1 623 ? 125.425 103.877 108.791 1.00 414.08 ? 623 ASN A C     1 
ATOM   4371 O O     . ASN A 1 623 ? 125.570 102.656 108.887 1.00 414.08 ? 623 ASN A O     1 
ATOM   4372 C CB    . ASN A 1 623 ? 127.181 105.457 107.834 1.00 414.08 ? 623 ASN A CB    1 
ATOM   4373 C CG    . ASN A 1 623 ? 127.578 104.426 106.802 1.00 414.08 ? 623 ASN A CG    1 
ATOM   4374 O OD1   . ASN A 1 623 ? 126.785 104.054 105.944 1.00 414.08 ? 623 ASN A OD1   1 
ATOM   4375 N ND2   . ASN A 1 623 ? 128.817 103.957 106.883 1.00 414.08 ? 623 ASN A ND2   1 
ATOM   4376 N N     . TRP A 1 624 ? 124.270 104.438 108.415 1.00 340.28 ? 624 TRP A N     1 
ATOM   4377 C CA    . TRP A 1 624 ? 123.131 103.579 108.101 1.00 340.28 ? 624 TRP A CA    1 
ATOM   4378 C C     . TRP A 1 624 ? 123.291 102.891 106.749 1.00 340.28 ? 624 TRP A C     1 
ATOM   4379 O O     . TRP A 1 624 ? 122.555 101.947 106.444 1.00 340.28 ? 624 TRP A O     1 
ATOM   4380 C CB    . TRP A 1 624 ? 121.840 104.402 108.138 1.00 340.28 ? 624 TRP A CB    1 
ATOM   4381 C CG    . TRP A 1 624 ? 120.563 103.599 108.121 1.00 340.28 ? 624 TRP A CG    1 
ATOM   4382 C CD1   . TRP A 1 624 ? 120.435 102.250 108.283 1.00 340.28 ? 624 TRP A CD1   1 
ATOM   4383 C CD2   . TRP A 1 624 ? 119.232 104.108 107.957 1.00 340.28 ? 624 TRP A CD2   1 
ATOM   4384 N NE1   . TRP A 1 624 ? 119.113 101.886 108.209 1.00 340.28 ? 624 TRP A NE1   1 
ATOM   4385 C CE2   . TRP A 1 624 ? 118.353 103.009 108.018 1.00 340.28 ? 624 TRP A CE2   1 
ATOM   4386 C CE3   . TRP A 1 624 ? 118.701 105.387 107.763 1.00 340.28 ? 624 TRP A CE3   1 
ATOM   4387 C CZ2   . TRP A 1 624 ? 116.973 103.150 107.892 1.00 340.28 ? 624 TRP A CZ2   1 
ATOM   4388 C CZ3   . TRP A 1 624 ? 117.331 105.522 107.634 1.00 340.28 ? 624 TRP A CZ3   1 
ATOM   4389 C CH2   . TRP A 1 624 ? 116.481 104.411 107.698 1.00 340.28 ? 624 TRP A CH2   1 
ATOM   4390 N N     . GLY A 1 625 ? 124.252 103.327 105.932 1.00 432.64 ? 625 GLY A N     1 
ATOM   4391 C CA    . GLY A 1 625 ? 124.409 102.715 104.623 1.00 432.64 ? 625 GLY A CA    1 
ATOM   4392 C C     . GLY A 1 625 ? 125.221 101.440 104.623 1.00 432.64 ? 625 GLY A C     1 
ATOM   4393 O O     . GLY A 1 625 ? 125.137 100.667 103.665 1.00 432.64 ? 625 GLY A O     1 
ATOM   4394 N N     . SER A 1 626 ? 125.987 101.194 105.690 1.00 459.07 ? 626 SER A N     1 
ATOM   4395 C CA    . SER A 1 626 ? 126.826 100.005 105.789 1.00 459.07 ? 626 SER A CA    1 
ATOM   4396 C C     . SER A 1 626 ? 126.048 98.703  105.660 1.00 459.07 ? 626 SER A C     1 
ATOM   4397 O O     . SER A 1 626 ? 126.604 97.723  105.153 1.00 459.07 ? 626 SER A O     1 
ATOM   4398 C CB    . SER A 1 626 ? 127.595 100.016 107.111 1.00 459.07 ? 626 SER A CB    1 
ATOM   4399 O OG    . SER A 1 626 ? 128.370 101.195 107.241 1.00 459.07 ? 626 SER A OG    1 
ATOM   4400 N N     . LYS A 1 627 ? 124.791 98.664  106.105 1.00 456.28 ? 627 LYS A N     1 
ATOM   4401 C CA    . LYS A 1 627 ? 124.005 97.441  105.977 1.00 456.28 ? 627 LYS A CA    1 
ATOM   4402 C C     . LYS A 1 627 ? 123.789 97.078  104.512 1.00 456.28 ? 627 LYS A C     1 
ATOM   4403 O O     . LYS A 1 627 ? 123.866 95.901  104.140 1.00 456.28 ? 627 LYS A O     1 
ATOM   4404 C CB    . LYS A 1 627 ? 122.663 97.599  106.692 1.00 456.28 ? 627 LYS A CB    1 
ATOM   4405 C CG    . LYS A 1 627 ? 121.737 96.404  106.532 1.00 456.28 ? 627 LYS A CG    1 
ATOM   4406 C CD    . LYS A 1 627 ? 120.392 96.651  107.193 1.00 456.28 ? 627 LYS A CD    1 
ATOM   4407 C CE    . LYS A 1 627 ? 119.433 95.499  106.932 1.00 456.28 ? 627 LYS A CE    1 
ATOM   4408 N NZ    . LYS A 1 627 ? 118.097 95.734  107.549 1.00 456.28 ? 627 LYS A NZ    1 
ATOM   4409 N N     . ASP A 1 628 ? 123.526 98.071  103.670 1.00 486.00 ? 628 ASP A N     1 
ATOM   4410 C CA    . ASP A 1 628 ? 123.296 97.841  102.251 1.00 486.00 ? 628 ASP A CA    1 
ATOM   4411 C C     . ASP A 1 628 ? 124.613 97.741  101.488 1.00 486.00 ? 628 ASP A C     1 
ATOM   4412 O O     . ASP A 1 628 ? 125.063 96.646  101.149 1.00 486.00 ? 628 ASP A O     1 
ATOM   4413 C CB    . ASP A 1 628 ? 122.432 98.961  101.671 1.00 486.00 ? 628 ASP A CB    1 
ATOM   4414 C CG    . ASP A 1 628 ? 121.146 99.162  102.449 1.00 486.00 ? 628 ASP A CG    1 
ATOM   4415 O OD1   . ASP A 1 628 ? 120.418 98.171  102.661 1.00 486.00 ? 628 ASP A OD1   1 
ATOM   4416 O OD2   . ASP A 1 628 ? 120.873 100.308 102.862 1.00 486.00 ? 628 ASP A OD2   1 
ATOM   4417 P P     . DC  B 2 9   ? 91.271  101.746 95.389  1.00 611.08 ? 9   DC  E P     1 
ATOM   4418 O OP1   . DC  B 2 9   ? 92.147  102.874 94.999  1.00 611.08 ? 9   DC  E OP1   1 
ATOM   4419 O OP2   . DC  B 2 9   ? 91.583  100.960 96.603  1.00 611.08 ? 9   DC  E OP2   1 
ATOM   4420 O "O5'" . DC  B 2 9   ? 89.769  102.282 95.517  1.00 611.08 ? 9   DC  E "O5'" 1 
ATOM   4421 C "C5'" . DC  B 2 9   ? 89.270  102.718 96.776  1.00 611.08 ? 9   DC  E "C5'" 1 
ATOM   4422 C "C4'" . DC  B 2 9   ? 88.604  104.077 96.648  1.00 611.08 ? 9   DC  E "C4'" 1 
ATOM   4423 O "O4'" . DC  B 2 9   ? 87.386  104.090 97.412  1.00 611.08 ? 9   DC  E "O4'" 1 
ATOM   4424 C "C3'" . DC  B 2 9   ? 89.422  105.246 97.186  1.00 611.08 ? 9   DC  E "C3'" 1 
ATOM   4425 O "O3'" . DC  B 2 9   ? 90.147  105.890 96.112  1.00 611.08 ? 9   DC  E "O3'" 1 
ATOM   4426 C "C2'" . DC  B 2 9   ? 88.388  106.170 97.864  1.00 611.08 ? 9   DC  E "C2'" 1 
ATOM   4427 C "C1'" . DC  B 2 9   ? 87.061  105.426 97.690  1.00 611.08 ? 9   DC  E "C1'" 1 
ATOM   4428 N N1    . DC  B 2 9   ? 86.192  105.457 98.901  1.00 611.08 ? 9   DC  E N1    1 
ATOM   4429 C C2    . DC  B 2 9   ? 85.148  106.387 98.980  1.00 611.08 ? 9   DC  E C2    1 
ATOM   4430 O O2    . DC  B 2 9   ? 84.966  107.170 98.040  1.00 611.08 ? 9   DC  E O2    1 
ATOM   4431 N N3    . DC  B 2 9   ? 84.368  106.405 100.088 1.00 611.08 ? 9   DC  E N3    1 
ATOM   4432 C C4    . DC  B 2 9   ? 84.598  105.543 101.081 1.00 611.08 ? 9   DC  E C4    1 
ATOM   4433 N N4    . DC  B 2 9   ? 83.802  105.597 102.153 1.00 611.08 ? 9   DC  E N4    1 
ATOM   4434 C C5    . DC  B 2 9   ? 85.656  104.588 101.019 1.00 611.08 ? 9   DC  E C5    1 
ATOM   4435 C C6    . DC  B 2 9   ? 86.421  104.582 99.921  1.00 611.08 ? 9   DC  E C6    1 
ATOM   4436 P P     . DT  B 2 10  ? 89.534  107.057 95.188  1.00 728.69 ? 10  DT  E P     1 
ATOM   4437 O OP1   . DT  B 2 10  ? 88.118  106.747 94.737  1.00 728.69 ? 10  DT  E OP1   1 
ATOM   4438 O OP2   . DT  B 2 10  ? 90.486  107.390 94.057  1.00 728.69 ? 10  DT  E OP2   1 
ATOM   4439 O "O5'" . DT  B 2 10  ? 89.475  108.349 96.158  1.00 728.69 ? 10  DT  E "O5'" 1 
ATOM   4440 C "C5'" . DT  B 2 10  ? 90.692  109.094 96.416  1.00 728.69 ? 10  DT  E "C5'" 1 
ATOM   4441 C "C4'" . DT  B 2 10  ? 91.297  108.627 97.717  1.00 728.69 ? 10  DT  E "C4'" 1 
ATOM   4442 O "O4'" . DT  B 2 10  ? 91.882  107.317 97.534  1.00 728.69 ? 10  DT  E "O4'" 1 
ATOM   4443 C "C3'" . DT  B 2 10  ? 92.414  109.512 98.265  1.00 728.69 ? 10  DT  E "C3'" 1 
ATOM   4444 O "O3'" . DT  B 2 10  ? 91.901  110.410 99.242  1.00 728.69 ? 10  DT  E "O3'" 1 
ATOM   4445 C "C2'" . DT  B 2 10  ? 93.335  108.500 98.924  1.00 728.69 ? 10  DT  E "C2'" 1 
ATOM   4446 C "C1'" . DT  B 2 10  ? 93.239  107.340 97.951  1.00 728.69 ? 10  DT  E "C1'" 1 
ATOM   4447 N N1    . DT  B 2 10  ? 94.068  107.517 96.746  1.00 728.69 ? 10  DT  E N1    1 
ATOM   4448 C C2    . DT  B 2 10  ? 95.432  107.625 96.904  1.00 728.69 ? 10  DT  E C2    1 
ATOM   4449 O O2    . DT  B 2 10  ? 95.991  107.568 97.992  1.00 728.69 ? 10  DT  E O2    1 
ATOM   4450 N N3    . DT  B 2 10  ? 96.127  107.805 95.737  1.00 728.69 ? 10  DT  E N3    1 
ATOM   4451 C C4    . DT  B 2 10  ? 95.612  107.881 94.457  1.00 728.69 ? 10  DT  E C4    1 
ATOM   4452 O O4    . DT  B 2 10  ? 96.372  108.042 93.499  1.00 728.69 ? 10  DT  E O4    1 
ATOM   4453 C C5    . DT  B 2 10  ? 94.176  107.766 94.365  1.00 728.69 ? 10  DT  E C5    1 
ATOM   4454 C C7    . DT  B 2 10  ? 93.532  107.842 93.013  1.00 728.69 ? 10  DT  E C7    1 
ATOM   4455 C C6    . DT  B 2 10  ? 93.482  107.590 95.499  1.00 728.69 ? 10  DT  E C6    1 
ATOM   4456 P P     . DC  B 2 11  ? 92.383  111.940 99.127  1.00 724.18 ? 11  DC  E P     1 
ATOM   4457 O OP1   . DC  B 2 11  ? 91.617  112.644 100.177 1.00 724.18 ? 11  DC  E OP1   1 
ATOM   4458 O OP2   . DC  B 2 11  ? 92.324  112.414 97.727  1.00 724.18 ? 11  DC  E OP2   1 
ATOM   4459 O "O5'" . DC  B 2 11  ? 93.918  111.899 99.564  1.00 724.18 ? 11  DC  E "O5'" 1 
ATOM   4460 C "C5'" . DC  B 2 11  ? 94.277  111.430 100.855 1.00 724.18 ? 11  DC  E "C5'" 1 
ATOM   4461 C "C4'" . DC  B 2 11  ? 95.778  111.227 100.954 1.00 724.18 ? 11  DC  E "C4'" 1 
ATOM   4462 O "O4'" . DC  B 2 11  ? 96.184  110.169 100.052 1.00 724.18 ? 11  DC  E "O4'" 1 
ATOM   4463 C "C3'" . DC  B 2 11  ? 96.604  112.431 100.546 1.00 724.18 ? 11  DC  E "C3'" 1 
ATOM   4464 O "O3'" . DC  B 2 11  ? 96.800  113.283 101.668 1.00 724.18 ? 11  DC  E "O3'" 1 
ATOM   4465 C "C2'" . DC  B 2 11  ? 97.908  111.789 100.095 1.00 724.18 ? 11  DC  E "C2'" 1 
ATOM   4466 C "C1'" . DC  B 2 11  ? 97.415  110.501 99.435  1.00 724.18 ? 11  DC  E "C1'" 1 
ATOM   4467 N N1    . DC  B 2 11  ? 97.184  110.615 97.967  1.00 724.18 ? 11  DC  E N1    1 
ATOM   4468 C C2    . DC  B 2 11  ? 98.274  110.591 97.084  1.00 724.18 ? 11  DC  E C2    1 
ATOM   4469 O O2    . DC  B 2 11  ? 99.425  110.481 97.537  1.00 724.18 ? 11  DC  E O2    1 
ATOM   4470 N N3    . DC  B 2 11  ? 98.033  110.690 95.755  1.00 724.18 ? 11  DC  E N3    1 
ATOM   4471 C C4    . DC  B 2 11  ? 96.783  110.802 95.303  1.00 724.18 ? 11  DC  E C4    1 
ATOM   4472 N N4    . DC  B 2 11  ? 96.605  110.895 93.977  1.00 724.18 ? 11  DC  E N4    1 
ATOM   4473 C C5    . DC  B 2 11  ? 95.664  110.826 96.183  1.00 724.18 ? 11  DC  E C5    1 
ATOM   4474 C C6    . DC  B 2 11  ? 95.907  110.727 97.492  1.00 724.18 ? 11  DC  E C6    1 
ATOM   4475 P P     . DT  B 2 12  ? 96.870  114.878 101.474 1.00 709.41 ? 12  DT  E P     1 
ATOM   4476 O OP1   . DT  B 2 12  ? 96.759  115.491 102.814 1.00 709.41 ? 12  DT  E OP1   1 
ATOM   4477 O OP2   . DT  B 2 12  ? 95.914  115.255 100.410 1.00 709.41 ? 12  DT  E OP2   1 
ATOM   4478 O "O5'" . DT  B 2 12  ? 98.346  115.126 100.912 1.00 709.41 ? 12  DT  E "O5'" 1 
ATOM   4479 C "C5'" . DT  B 2 12  ? 99.470  114.724 101.682 1.00 709.41 ? 12  DT  E "C5'" 1 
ATOM   4480 C "C4'" . DT  B 2 12  ? 100.717 114.647 100.823 1.00 709.41 ? 12  DT  E "C4'" 1 
ATOM   4481 O "O4'" . DT  B 2 12  ? 100.558 113.604 99.833  1.00 709.41 ? 12  DT  E "O4'" 1 
ATOM   4482 C "C3'" . DT  B 2 12  ? 101.018 115.898 100.024 1.00 709.41 ? 12  DT  E "C3'" 1 
ATOM   4483 O "O3'" . DT  B 2 12  ? 101.749 116.820 100.827 1.00 709.41 ? 12  DT  E "O3'" 1 
ATOM   4484 C "C2'" . DT  B 2 12  ? 101.868 115.343 98.886  1.00 709.41 ? 12  DT  E "C2'" 1 
ATOM   4485 C "C1'" . DT  B 2 12  ? 101.217 113.978 98.635  1.00 709.41 ? 12  DT  E "C1'" 1 
ATOM   4486 N N1    . DT  B 2 12  ? 100.219 113.978 97.523  1.00 709.41 ? 12  DT  E N1    1 
ATOM   4487 C C2    . DT  B 2 12  ? 100.652 113.830 96.224  1.00 709.41 ? 12  DT  E C2    1 
ATOM   4488 O O2    . DT  B 2 12  ? 101.825 113.698 95.920  1.00 709.41 ? 12  DT  E O2    1 
ATOM   4489 N N3    . DT  B 2 12  ? 99.654  113.842 95.284  1.00 709.41 ? 12  DT  E N3    1 
ATOM   4490 C C4    . DT  B 2 12  ? 98.296  113.983 95.511  1.00 709.41 ? 12  DT  E C4    1 
ATOM   4491 O O4    . DT  B 2 12  ? 97.474  113.981 94.601  1.00 709.41 ? 12  DT  E O4    1 
ATOM   4492 C C5    . DT  B 2 12  ? 97.913  114.131 96.895  1.00 709.41 ? 12  DT  E C5    1 
ATOM   4493 C C7    . DT  B 2 12  ? 96.468  114.290 97.265  1.00 709.41 ? 12  DT  E C7    1 
ATOM   4494 C C6    . DT  B 2 12  ? 98.880  114.123 97.820  1.00 709.41 ? 12  DT  E C6    1 
ATOM   4495 P P     . DA  B 2 13  ? 101.552 118.402 100.629 1.00 639.93 ? 13  DA  E P     1 
ATOM   4496 O OP1   . DA  B 2 13  ? 101.973 119.079 101.878 1.00 639.93 ? 13  DA  E OP1   1 
ATOM   4497 O OP2   . DA  B 2 13  ? 100.188 118.623 100.103 1.00 639.93 ? 13  DA  E OP2   1 
ATOM   4498 O "O5'" . DA  B 2 13  ? 102.581 118.768 99.461  1.00 639.93 ? 13  DA  E "O5'" 1 
ATOM   4499 C "C5'" . DA  B 2 13  ? 103.961 118.461 99.616  1.00 639.93 ? 13  DA  E "C5'" 1 
ATOM   4500 C "C4'" . DA  B 2 13  ? 104.660 118.400 98.271  1.00 639.93 ? 13  DA  E "C4'" 1 
ATOM   4501 O "O4'" . DA  B 2 13  ? 103.955 117.485 97.392  1.00 639.93 ? 13  DA  E "O4'" 1 
ATOM   4502 C "C3'" . DA  B 2 13  ? 104.739 119.729 97.513  1.00 639.93 ? 13  DA  E "C3'" 1 
ATOM   4503 O "O3'" . DA  B 2 13  ? 106.005 119.842 96.871  1.00 639.93 ? 13  DA  E "O3'" 1 
ATOM   4504 C "C2'" . DA  B 2 13  ? 103.613 119.600 96.498  1.00 639.93 ? 13  DA  E "C2'" 1 
ATOM   4505 C "C1'" . DA  B 2 13  ? 103.709 118.124 96.165  1.00 639.93 ? 13  DA  E "C1'" 1 
ATOM   4506 N N9    . DA  B 2 13  ? 102.493 117.582 95.585  1.00 639.93 ? 13  DA  E N9    1 
ATOM   4507 C C8    . DA  B 2 13  ? 101.305 117.364 96.224  1.00 639.93 ? 13  DA  E C8    1 
ATOM   4508 N N7    . DA  B 2 13  ? 100.378 116.861 95.447  1.00 639.93 ? 13  DA  E N7    1 
ATOM   4509 C C5    . DA  B 2 13  ? 101.002 116.747 94.220  1.00 639.93 ? 13  DA  E C5    1 
ATOM   4510 C C6    . DA  B 2 13  ? 100.550 116.282 92.980  1.00 639.93 ? 13  DA  E C6    1 
ATOM   4511 N N6    . DA  B 2 13  ? 99.316  115.827 92.781  1.00 639.93 ? 13  DA  E N6    1 
ATOM   4512 N N1    . DA  B 2 13  ? 101.420 116.301 91.947  1.00 639.93 ? 13  DA  E N1    1 
ATOM   4513 C C2    . DA  B 2 13  ? 102.659 116.757 92.159  1.00 639.93 ? 13  DA  E C2    1 
ATOM   4514 N N3    . DA  B 2 13  ? 103.199 117.222 93.285  1.00 639.93 ? 13  DA  E N3    1 
ATOM   4515 C C4    . DA  B 2 13  ? 102.306 117.188 94.287  1.00 639.93 ? 13  DA  E C4    1 
ATOM   4516 P P     . DC  B 2 14  ? 106.526 121.263 96.328  1.00 602.29 ? 14  DC  E P     1 
ATOM   4517 O OP1   . DC  B 2 14  ? 107.766 121.585 97.070  1.00 602.29 ? 14  DC  E OP1   1 
ATOM   4518 O OP2   . DC  B 2 14  ? 105.394 122.212 96.352  1.00 602.29 ? 14  DC  E OP2   1 
ATOM   4519 O "O5'" . DC  B 2 14  ? 106.897 120.978 94.794  1.00 602.29 ? 14  DC  E "O5'" 1 
ATOM   4520 C "C5'" . DC  B 2 14  ? 106.043 120.158 93.998  1.00 602.29 ? 14  DC  E "C5'" 1 
ATOM   4521 C "C4'" . DC  B 2 14  ? 105.961 120.676 92.572  1.00 602.29 ? 14  DC  E "C4'" 1 
ATOM   4522 O "O4'" . DC  B 2 14  ? 104.815 120.073 91.911  1.00 602.29 ? 14  DC  E "O4'" 1 
ATOM   4523 C "C3'" . DC  B 2 14  ? 105.750 122.175 92.448  1.00 602.29 ? 14  DC  E "C3'" 1 
ATOM   4524 O "O3'" . DC  B 2 14  ? 106.277 122.632 91.209  1.00 602.29 ? 14  DC  E "O3'" 1 
ATOM   4525 C "C2'" . DC  B 2 14  ? 104.233 122.281 92.475  1.00 602.29 ? 14  DC  E "C2'" 1 
ATOM   4526 C "C1'" . DC  B 2 14  ? 103.837 121.063 91.651  1.00 602.29 ? 14  DC  E "C1'" 1 
ATOM   4527 N N1    . DC  B 2 14  ? 102.512 120.516 92.027  1.00 602.29 ? 14  DC  E N1    1 
ATOM   4528 C C2    . DC  B 2 14  ? 101.694 119.933 91.052  1.00 602.29 ? 14  DC  E C2    1 
ATOM   4529 O O2    . DC  B 2 14  ? 102.088 119.883 89.880  1.00 602.29 ? 14  DC  E O2    1 
ATOM   4530 N N3    . DC  B 2 14  ? 100.487 119.438 91.425  1.00 602.29 ? 14  DC  E N3    1 
ATOM   4531 C C4    . DC  B 2 14  ? 100.103 119.515 92.701  1.00 602.29 ? 14  DC  E C4    1 
ATOM   4532 N N4    . DC  B 2 14  ? 98.908  119.013 93.029  1.00 602.29 ? 14  DC  E N4    1 
ATOM   4533 C C5    . DC  B 2 14  ? 100.922 120.107 93.702  1.00 602.29 ? 14  DC  E C5    1 
ATOM   4534 C C6    . DC  B 2 14  ? 102.105 120.588 93.324  1.00 602.29 ? 14  DC  E C6    1 
ATOM   4535 P P     . DG  B 2 15  ? 106.713 124.169 91.030  1.00 592.01 ? 15  DG  E P     1 
ATOM   4536 O OP1   . DG  B 2 15  ? 108.190 124.220 91.078  1.00 592.01 ? 15  DG  E OP1   1 
ATOM   4537 O OP2   . DG  B 2 15  ? 105.917 124.982 91.974  1.00 592.01 ? 15  DG  E OP2   1 
ATOM   4538 O "O5'" . DG  B 2 15  ? 106.237 124.531 89.547  1.00 592.01 ? 15  DG  E "O5'" 1 
ATOM   4539 C "C5'" . DG  B 2 15  ? 106.710 123.771 88.445  1.00 592.01 ? 15  DG  E "C5'" 1 
ATOM   4540 C "C4'" . DG  B 2 15  ? 105.628 123.608 87.392  1.00 592.01 ? 15  DG  E "C4'" 1 
ATOM   4541 O "O4'" . DG  B 2 15  ? 104.475 122.936 87.975  1.00 592.01 ? 15  DG  E "O4'" 1 
ATOM   4542 C "C3'" . DG  B 2 15  ? 105.093 124.914 86.803  1.00 592.01 ? 15  DG  E "C3'" 1 
ATOM   4543 O "O3'" . DG  B 2 15  ? 104.803 124.729 85.425  1.00 592.01 ? 15  DG  E "O3'" 1 
ATOM   4544 C "C2'" . DG  B 2 15  ? 103.821 125.139 87.607  1.00 592.01 ? 15  DG  E "C2'" 1 
ATOM   4545 C "C1'" . DG  B 2 15  ? 103.322 123.712 87.742  1.00 592.01 ? 15  DG  E "C1'" 1 
ATOM   4546 N N9    . DG  B 2 15  ? 102.392 123.519 88.848  1.00 592.01 ? 15  DG  E N9    1 
ATOM   4547 C C8    . DG  B 2 15  ? 102.530 123.977 90.133  1.00 592.01 ? 15  DG  E C8    1 
ATOM   4548 N N7    . DG  B 2 15  ? 101.535 123.652 90.911  1.00 592.01 ? 15  DG  E N7    1 
ATOM   4549 C C5    . DG  B 2 15  ? 100.681 122.933 90.085  1.00 592.01 ? 15  DG  E C5    1 
ATOM   4550 C C6    . DG  B 2 15  ? 99.437  122.324 90.370  1.00 592.01 ? 15  DG  E C6    1 
ATOM   4551 O O6    . DG  B 2 15  ? 98.824  122.299 91.445  1.00 592.01 ? 15  DG  E O6    1 
ATOM   4552 N N1    . DG  B 2 15  ? 98.903  121.694 89.249  1.00 592.01 ? 15  DG  E N1    1 
ATOM   4553 C C2    . DG  B 2 15  ? 99.497  121.659 88.010  1.00 592.01 ? 15  DG  E C2    1 
ATOM   4554 N N2    . DG  B 2 15  ? 98.829  121.003 87.049  1.00 592.01 ? 15  DG  E N2    1 
ATOM   4555 N N3    . DG  B 2 15  ? 100.661 122.227 87.730  1.00 592.01 ? 15  DG  E N3    1 
ATOM   4556 C C4    . DG  B 2 15  ? 101.194 122.843 88.813  1.00 592.01 ? 15  DG  E C4    1 
ATOM   4557 P P     . DG  B 2 16  ? 104.450 125.979 84.481  1.00 587.70 ? 16  DG  E P     1 
ATOM   4558 O OP1   . DG  B 2 16  ? 105.697 126.749 84.284  1.00 587.70 ? 16  DG  E OP1   1 
ATOM   4559 O OP2   . DG  B 2 16  ? 103.240 126.657 85.001  1.00 587.70 ? 16  DG  E OP2   1 
ATOM   4560 O "O5'" . DG  B 2 16  ? 104.046 125.291 83.100  1.00 587.70 ? 16  DG  E "O5'" 1 
ATOM   4561 C "C5'" . DG  B 2 16  ? 103.505 123.973 83.101  1.00 587.70 ? 16  DG  E "C5'" 1 
ATOM   4562 C "C4'" . DG  B 2 16  ? 101.986 124.006 83.122  1.00 587.70 ? 16  DG  E "C4'" 1 
ATOM   4563 O "O4'" . DG  B 2 16  ? 101.505 123.926 84.477  1.00 587.70 ? 16  DG  E "O4'" 1 
ATOM   4564 C "C3'" . DG  B 2 16  ? 101.353 125.269 82.537  1.00 587.70 ? 16  DG  E "C3'" 1 
ATOM   4565 O "O3'" . DG  B 2 16  ? 100.806 124.982 81.254  1.00 587.70 ? 16  DG  E "O3'" 1 
ATOM   4566 C "C2'" . DG  B 2 16  ? 100.261 125.661 83.553  1.00 587.70 ? 16  DG  E "C2'" 1 
ATOM   4567 C "C1'" . DG  B 2 16  ? 100.211 124.461 84.493  1.00 587.70 ? 16  DG  E "C1'" 1 
ATOM   4568 N N9    . DG  B 2 16  ? 99.853  124.803 85.868  1.00 587.70 ? 16  DG  E N9    1 
ATOM   4569 C C8    . DG  B 2 16  ? 100.570 125.582 86.740  1.00 587.70 ? 16  DG  E C8    1 
ATOM   4570 N N7    . DG  B 2 16  ? 100.003 125.715 87.907  1.00 587.70 ? 16  DG  E N7    1 
ATOM   4571 C C5    . DG  B 2 16  ? 98.830  124.977 87.800  1.00 587.70 ? 16  DG  E C5    1 
ATOM   4572 C C6    . DG  B 2 16  ? 97.806  124.752 88.748  1.00 587.70 ? 16  DG  E C6    1 
ATOM   4573 O O6    . DG  B 2 16  ? 97.728  125.175 89.910  1.00 587.70 ? 16  DG  E O6    1 
ATOM   4574 N N1    . DG  B 2 16  ? 96.793  123.947 88.234  1.00 587.70 ? 16  DG  E N1    1 
ATOM   4575 C C2    . DG  B 2 16  ? 96.775  123.424 86.963  1.00 587.70 ? 16  DG  E C2    1 
ATOM   4576 N N2    . DG  B 2 16  ? 95.712  122.669 86.645  1.00 587.70 ? 16  DG  E N2    1 
ATOM   4577 N N3    . DG  B 2 16  ? 97.729  123.627 86.063  1.00 587.70 ? 16  DG  E N3    1 
ATOM   4578 C C4    . DG  B 2 16  ? 98.721  124.410 86.551  1.00 587.70 ? 16  DG  E C4    1 
ATOM   4579 P P     . DA  B 2 17  ? 99.962  126.093 80.457  1.00 609.64 ? 17  DA  E P     1 
ATOM   4580 O OP1   . DA  B 2 17  ? 100.045 125.761 79.016  1.00 609.64 ? 17  DA  E OP1   1 
ATOM   4581 O OP2   . DA  B 2 17  ? 100.395 127.428 80.923  1.00 609.64 ? 17  DA  E OP2   1 
ATOM   4582 O "O5'" . DA  B 2 17  ? 98.461  125.852 80.950  1.00 609.64 ? 17  DA  E "O5'" 1 
ATOM   4583 C "C5'" . DA  B 2 17  ? 97.945  124.528 81.015  1.00 609.64 ? 17  DA  E "C5'" 1 
ATOM   4584 C "C4'" . DA  B 2 17  ? 96.613  124.503 81.742  1.00 609.64 ? 17  DA  E "C4'" 1 
ATOM   4585 O "O4'" . DA  B 2 17  ? 96.824  124.726 83.161  1.00 609.64 ? 17  DA  E "O4'" 1 
ATOM   4586 C "C3'" . DA  B 2 17  ? 95.610  125.568 81.286  1.00 609.64 ? 17  DA  E "C3'" 1 
ATOM   4587 O "O3'" . DA  B 2 17  ? 94.368  124.959 80.954  1.00 609.64 ? 17  DA  E "O3'" 1 
ATOM   4588 C "C2'" . DA  B 2 17  ? 95.478  126.490 82.499  1.00 609.64 ? 17  DA  E "C2'" 1 
ATOM   4589 C "C1'" . DA  B 2 17  ? 95.789  125.543 83.641  1.00 609.64 ? 17  DA  E "C1'" 1 
ATOM   4590 N N9    . DA  B 2 17  ? 96.238  126.222 84.851  1.00 609.64 ? 17  DA  E N9    1 
ATOM   4591 C C8    . DA  B 2 17  ? 97.407  126.908 85.030  1.00 609.64 ? 17  DA  E C8    1 
ATOM   4592 N N7    . DA  B 2 17  ? 97.538  127.424 86.230  1.00 609.64 ? 17  DA  E N7    1 
ATOM   4593 C C5    . DA  B 2 17  ? 96.374  127.052 86.880  1.00 609.64 ? 17  DA  E C5    1 
ATOM   4594 C C6    . DA  B 2 17  ? 95.899  127.288 88.185  1.00 609.64 ? 17  DA  E C6    1 
ATOM   4595 N N6    . DA  B 2 17  ? 96.577  127.984 89.102  1.00 609.64 ? 17  DA  E N6    1 
ATOM   4596 N N1    . DA  B 2 17  ? 94.694  126.776 88.510  1.00 609.64 ? 17  DA  E N1    1 
ATOM   4597 C C2    . DA  B 2 17  ? 94.019  126.075 87.593  1.00 609.64 ? 17  DA  E C2    1 
ATOM   4598 N N3    . DA  B 2 17  ? 94.362  125.790 86.339  1.00 609.64 ? 17  DA  E N3    1 
ATOM   4599 C C4    . DA  B 2 17  ? 95.561  126.313 86.044  1.00 609.64 ? 17  DA  E C4    1 
ATOM   4600 P P     . DT  B 2 18  ? 93.524  125.486 79.691  1.00 626.45 ? 18  DT  E P     1 
ATOM   4601 O OP1   . DT  B 2 18  ? 93.232  124.319 78.829  1.00 626.45 ? 18  DT  E OP1   1 
ATOM   4602 O OP2   . DT  B 2 18  ? 94.242  126.652 79.131  1.00 626.45 ? 18  DT  E OP2   1 
ATOM   4603 O "O5'" . DT  B 2 18  ? 92.157  126.014 80.331  1.00 626.45 ? 18  DT  E "O5'" 1 
ATOM   4604 C "C5'" . DT  B 2 18  ? 92.182  127.012 81.345  1.00 626.45 ? 18  DT  E "C5'" 1 
ATOM   4605 C "C4'" . DT  B 2 18  ? 91.354  126.586 82.543  1.00 626.45 ? 18  DT  E "C4'" 1 
ATOM   4606 O "O4'" . DT  B 2 18  ? 92.117  126.789 83.764  1.00 626.45 ? 18  DT  E "O4'" 1 
ATOM   4607 C "C3'" . DT  B 2 18  ? 90.047  127.357 82.730  1.00 626.45 ? 18  DT  E "C3'" 1 
ATOM   4608 O "O3'" . DT  B 2 18  ? 89.023  126.475 83.169  1.00 626.45 ? 18  DT  E "O3'" 1 
ATOM   4609 C "C2'" . DT  B 2 18  ? 90.408  128.370 83.810  1.00 626.45 ? 18  DT  E "C2'" 1 
ATOM   4610 C "C1'" . DT  B 2 18  ? 91.349  127.547 84.671  1.00 626.45 ? 18  DT  E "C1'" 1 
ATOM   4611 N N1    . DT  B 2 18  ? 92.267  128.368 85.508  1.00 626.45 ? 18  DT  E N1    1 
ATOM   4612 C C2    . DT  B 2 18  ? 91.904  128.676 86.799  1.00 626.45 ? 18  DT  E C2    1 
ATOM   4613 O O2    . DT  B 2 18  ? 90.859  128.312 87.305  1.00 626.45 ? 18  DT  E O2    1 
ATOM   4614 N N3    . DT  B 2 18  ? 92.816  129.435 87.483  1.00 626.45 ? 18  DT  E N3    1 
ATOM   4615 C C4    . DT  B 2 18  ? 94.030  129.904 87.014  1.00 626.45 ? 18  DT  E C4    1 
ATOM   4616 O O4    . DT  B 2 18  ? 94.783  130.578 87.706  1.00 626.45 ? 18  DT  E O4    1 
ATOM   4617 C C5    . DT  B 2 18  ? 94.348  129.543 85.654  1.00 626.45 ? 18  DT  E C5    1 
ATOM   4618 C C7    . DT  B 2 18  ? 95.638  129.997 85.037  1.00 626.45 ? 18  DT  E C7    1 
ATOM   4619 C C6    . DT  B 2 18  ? 93.461  128.801 84.974  1.00 626.45 ? 18  DT  E C6    1 
ATOM   4620 P P     . DG  B 2 19  ? 87.478  126.873 82.979  1.00 632.27 ? 19  DG  E P     1 
ATOM   4621 O OP1   . DG  B 2 19  ? 86.665  125.674 83.278  1.00 632.27 ? 19  DG  E OP1   1 
ATOM   4622 O OP2   . DG  B 2 19  ? 87.348  127.544 81.666  1.00 632.27 ? 19  DG  E OP2   1 
ATOM   4623 O "O5'" . DG  B 2 19  ? 87.220  127.970 84.114  1.00 632.27 ? 19  DG  E "O5'" 1 
ATOM   4624 C "C5'" . DG  B 2 19  ? 87.358  127.624 85.488  1.00 632.27 ? 19  DG  E "C5'" 1 
ATOM   4625 C "C4'" . DG  B 2 19  ? 87.074  128.826 86.368  1.00 632.27 ? 19  DG  E "C4'" 1 
ATOM   4626 O "O4'" . DG  B 2 19  ? 88.323  129.401 86.832  1.00 632.27 ? 19  DG  E "O4'" 1 
ATOM   4627 C "C3'" . DG  B 2 19  ? 86.311  129.960 85.673  1.00 632.27 ? 19  DG  E "C3'" 1 
ATOM   4628 O "O3'" . DG  B 2 19  ? 85.182  130.337 86.445  1.00 632.27 ? 19  DG  E "O3'" 1 
ATOM   4629 C "C2'" . DG  B 2 19  ? 87.336  131.092 85.585  1.00 632.27 ? 19  DG  E "C2'" 1 
ATOM   4630 C "C1'" . DG  B 2 19  ? 88.219  130.801 86.784  1.00 632.27 ? 19  DG  E "C1'" 1 
ATOM   4631 N N9    . DG  B 2 19  ? 89.558  131.371 86.671  1.00 632.27 ? 19  DG  E N9    1 
ATOM   4632 C C8    . DG  B 2 19  ? 90.399  131.301 85.588  1.00 632.27 ? 19  DG  E C8    1 
ATOM   4633 N N7    . DG  B 2 19  ? 91.536  131.913 85.773  1.00 632.27 ? 19  DG  E N7    1 
ATOM   4634 C C5    . DG  B 2 19  ? 91.440  132.427 87.059  1.00 632.27 ? 19  DG  E C5    1 
ATOM   4635 C C6    . DG  B 2 19  ? 92.365  133.188 87.806  1.00 632.27 ? 19  DG  E C6    1 
ATOM   4636 O O6    . DG  B 2 19  ? 93.494  133.568 87.469  1.00 632.27 ? 19  DG  E O6    1 
ATOM   4637 N N1    . DG  B 2 19  ? 91.873  133.505 89.070  1.00 632.27 ? 19  DG  E N1    1 
ATOM   4638 C C2    . DG  B 2 19  ? 90.640  133.131 89.549  1.00 632.27 ? 19  DG  E C2    1 
ATOM   4639 N N2    . DG  B 2 19  ? 90.341  133.532 90.794  1.00 632.27 ? 19  DG  E N2    1 
ATOM   4640 N N3    . DG  B 2 19  ? 89.761  132.420 88.857  1.00 632.27 ? 19  DG  E N3    1 
ATOM   4641 C C4    . DG  B 2 19  ? 90.227  132.104 87.624  1.00 632.27 ? 19  DG  E C4    1 
ATOM   4642 P P     . DC  B 2 20  ? 83.780  130.634 85.718  1.00 673.54 ? 20  DC  E P     1 
ATOM   4643 O OP1   . DC  B 2 20  ? 82.967  129.400 85.788  1.00 673.54 ? 20  DC  E OP1   1 
ATOM   4644 O OP2   . DC  B 2 20  ? 84.082  131.245 84.405  1.00 673.54 ? 20  DC  E OP2   1 
ATOM   4645 O "O5'" . DC  B 2 20  ? 83.098  131.753 86.635  1.00 673.54 ? 20  DC  E "O5'" 1 
ATOM   4646 C "C5'" . DC  B 2 20  ? 83.697  133.038 86.751  1.00 673.54 ? 20  DC  E "C5'" 1 
ATOM   4647 C "C4'" . DC  B 2 20  ? 84.300  133.230 88.131  1.00 673.54 ? 20  DC  E "C4'" 1 
ATOM   4648 O "O4'" . DC  B 2 20  ? 85.749  133.171 88.040  1.00 673.54 ? 20  DC  E "O4'" 1 
ATOM   4649 C "C3'" . DC  B 2 20  ? 83.974  134.570 88.789  1.00 673.54 ? 20  DC  E "C3'" 1 
ATOM   4650 O "O3'" . DC  B 2 20  ? 83.787  134.395 90.188  1.00 673.54 ? 20  DC  E "O3'" 1 
ATOM   4651 C "C2'" . DC  B 2 20  ? 85.213  135.405 88.489  1.00 673.54 ? 20  DC  E "C2'" 1 
ATOM   4652 C "C1'" . DC  B 2 20  ? 86.309  134.355 88.567  1.00 673.54 ? 20  DC  E "C1'" 1 
ATOM   4653 N N1    . DC  B 2 20  ? 87.522  134.702 87.774  1.00 673.54 ? 20  DC  E N1    1 
ATOM   4654 C C2    . DC  B 2 20  ? 88.620  135.291 88.411  1.00 673.54 ? 20  DC  E C2    1 
ATOM   4655 O O2    . DC  B 2 20  ? 88.567  135.508 89.628  1.00 673.54 ? 20  DC  E O2    1 
ATOM   4656 N N3    . DC  B 2 20  ? 89.716  135.598 87.676  1.00 673.54 ? 20  DC  E N3    1 
ATOM   4657 C C4    . DC  B 2 20  ? 89.735  135.346 86.367  1.00 673.54 ? 20  DC  E C4    1 
ATOM   4658 N N4    . DC  B 2 20  ? 90.837  135.669 85.683  1.00 673.54 ? 20  DC  E N4    1 
ATOM   4659 C C5    . DC  B 2 20  ? 88.624  134.749 85.700  1.00 673.54 ? 20  DC  E C5    1 
ATOM   4660 C C6    . DC  B 2 20  ? 87.549  134.450 86.436  1.00 673.54 ? 20  DC  E C6    1 
ATOM   4661 P P     . DC  B 2 21  ? 82.900  135.446 91.018  1.00 663.03 ? 21  DC  E P     1 
ATOM   4662 O OP1   . DC  B 2 21  ? 82.306  134.725 92.167  1.00 663.03 ? 21  DC  E OP1   1 
ATOM   4663 O OP2   . DC  B 2 21  ? 82.023  136.150 90.057  1.00 663.03 ? 21  DC  E OP2   1 
ATOM   4664 O "O5'" . DC  B 2 21  ? 83.968  136.500 91.570  1.00 663.03 ? 21  DC  E "O5'" 1 
ATOM   4665 C "C5'" . DC  B 2 21  ? 84.877  136.120 92.595  1.00 663.03 ? 21  DC  E "C5'" 1 
ATOM   4666 C "C4'" . DC  B 2 21  ? 85.872  137.233 92.874  1.00 663.03 ? 21  DC  E "C4'" 1 
ATOM   4667 O "O4'" . DC  B 2 21  ? 86.916  137.214 91.872  1.00 663.03 ? 21  DC  E "O4'" 1 
ATOM   4668 C "C3'" . DC  B 2 21  ? 85.281  138.649 92.864  1.00 663.03 ? 21  DC  E "C3'" 1 
ATOM   4669 O "O3'" . DC  B 2 21  ? 85.549  139.302 94.101  1.00 663.03 ? 21  DC  E "O3'" 1 
ATOM   4670 C "C2'" . DC  B 2 21  ? 85.984  139.344 91.690  1.00 663.03 ? 21  DC  E "C2'" 1 
ATOM   4671 C "C1'" . DC  B 2 21  ? 87.262  138.534 91.542  1.00 663.03 ? 21  DC  E "C1'" 1 
ATOM   4672 N N1    . DC  B 2 21  ? 87.799  138.544 90.161  1.00 663.03 ? 21  DC  E N1    1 
ATOM   4673 C C2    . DC  B 2 21  ? 89.160  138.772 89.949  1.00 663.03 ? 21  DC  E C2    1 
ATOM   4674 O O2    . DC  B 2 21  ? 89.898  138.961 90.921  1.00 663.03 ? 21  DC  E O2    1 
ATOM   4675 N N3    . DC  B 2 21  ? 89.631  138.778 88.679  1.00 663.03 ? 21  DC  E N3    1 
ATOM   4676 C C4    . DC  B 2 21  ? 88.801  138.569 87.658  1.00 663.03 ? 21  DC  E C4    1 
ATOM   4677 N N4    . DC  B 2 21  ? 89.313  138.582 86.423  1.00 663.03 ? 21  DC  E N4    1 
ATOM   4678 C C5    . DC  B 2 21  ? 87.411  138.335 87.853  1.00 663.03 ? 21  DC  E C5    1 
ATOM   4679 C C6    . DC  B 2 21  ? 86.958  138.334 89.110  1.00 663.03 ? 21  DC  E C6    1 
ATOM   4680 P P     . DT  B 2 22  ? 84.934  140.756 94.401  1.00 640.66 ? 22  DT  E P     1 
ATOM   4681 O OP1   . DT  B 2 22  ? 84.628  140.820 95.849  1.00 640.66 ? 22  DT  E OP1   1 
ATOM   4682 O OP2   . DT  B 2 22  ? 83.866  141.024 93.410  1.00 640.66 ? 22  DT  E OP2   1 
ATOM   4683 O "O5'" . DT  B 2 22  ? 86.147  141.748 94.097  1.00 640.66 ? 22  DT  E "O5'" 1 
ATOM   4684 C "C5'" . DT  B 2 22  ? 87.389  141.567 94.760  1.00 640.66 ? 22  DT  E "C5'" 1 
ATOM   4685 C "C4'" . DT  B 2 22  ? 88.457  142.462 94.163  1.00 640.66 ? 22  DT  E "C4'" 1 
ATOM   4686 O "O4'" . DT  B 2 22  ? 88.770  142.020 92.816  1.00 640.66 ? 22  DT  E "O4'" 1 
ATOM   4687 C "C3'" . DT  B 2 22  ? 88.075  143.937 94.054  1.00 640.66 ? 22  DT  E "C3'" 1 
ATOM   4688 O "O3'" . DT  B 2 22  ? 89.176  144.743 94.440  1.00 640.66 ? 22  DT  E "O3'" 1 
ATOM   4689 C "C2'" . DT  B 2 22  ? 87.749  144.104 92.571  1.00 640.66 ? 22  DT  E "C2'" 1 
ATOM   4690 C "C1'" . DT  B 2 22  ? 88.717  143.118 91.937  1.00 640.66 ? 22  DT  E "C1'" 1 
ATOM   4691 N N1    . DT  B 2 22  ? 88.281  142.629 90.602  1.00 640.66 ? 22  DT  E N1    1 
ATOM   4692 C C2    . DT  B 2 22  ? 89.206  142.060 89.761  1.00 640.66 ? 22  DT  E C2    1 
ATOM   4693 O O2    . DT  B 2 22  ? 90.380  141.928 90.054  1.00 640.66 ? 22  DT  E O2    1 
ATOM   4694 N N3    . DT  B 2 22  ? 88.705  141.640 88.559  1.00 640.66 ? 22  DT  E N3    1 
ATOM   4695 C C4    . DT  B 2 22  ? 87.397  141.735 88.123  1.00 640.66 ? 22  DT  E C4    1 
ATOM   4696 O O4    . DT  B 2 22  ? 87.043  141.330 87.019  1.00 640.66 ? 22  DT  E O4    1 
ATOM   4697 C C5    . DT  B 2 22  ? 86.477  142.346 89.051  1.00 640.66 ? 22  DT  E C5    1 
ATOM   4698 C C7    . DT  B 2 22  ? 85.031  142.502 88.689  1.00 640.66 ? 22  DT  E C7    1 
ATOM   4699 C C6    . DT  B 2 22  ? 86.958  142.758 90.232  1.00 640.66 ? 22  DT  E C6    1 
ATOM   4700 P P     . DC  B 2 23  ? 88.934  146.162 95.155  1.00 623.25 ? 23  DC  E P     1 
ATOM   4701 O OP1   . DC  B 2 23  ? 89.353  146.020 96.569  1.00 623.25 ? 23  DC  E OP1   1 
ATOM   4702 O OP2   . DC  B 2 23  ? 87.563  146.609 94.828  1.00 623.25 ? 23  DC  E OP2   1 
ATOM   4703 O "O5'" . DC  B 2 23  ? 89.970  147.126 94.416  1.00 623.25 ? 23  DC  E "O5'" 1 
ATOM   4704 C "C5'" . DC  B 2 23  ? 91.352  146.798 94.422  1.00 623.25 ? 23  DC  E "C5'" 1 
ATOM   4705 C "C4'" . DC  B 2 23  ? 92.052  147.352 93.195  1.00 623.25 ? 23  DC  E "C4'" 1 
ATOM   4706 O "O4'" . DC  B 2 23  ? 91.587  146.652 92.010  1.00 623.25 ? 23  DC  E "O4'" 1 
ATOM   4707 C "C3'" . DC  B 2 23  ? 91.812  148.838 92.941  1.00 623.25 ? 23  DC  E "C3'" 1 
ATOM   4708 O "O3'" . DC  B 2 23  ? 93.037  149.498 92.632  1.00 623.25 ? 23  DC  E "O3'" 1 
ATOM   4709 C "C2'" . DC  B 2 23  ? 90.842  148.852 91.761  1.00 623.25 ? 23  DC  E "C2'" 1 
ATOM   4710 C "C1'" . DC  B 2 23  ? 91.224  147.583 91.019  1.00 623.25 ? 23  DC  E "C1'" 1 
ATOM   4711 N N1    . DC  B 2 23  ? 90.104  147.010 90.214  1.00 623.25 ? 23  DC  E N1    1 
ATOM   4712 C C2    . DC  B 2 23  ? 90.373  146.420 88.977  1.00 623.25 ? 23  DC  E C2    1 
ATOM   4713 O O2    . DC  B 2 23  ? 91.540  146.378 88.576  1.00 623.25 ? 23  DC  E O2    1 
ATOM   4714 N N3    . DC  B 2 23  ? 89.346  145.907 88.258  1.00 623.25 ? 23  DC  E N3    1 
ATOM   4715 C C4    . DC  B 2 23  ? 88.101  145.976 88.731  1.00 623.25 ? 23  DC  E C4    1 
ATOM   4716 N N4    . DC  B 2 23  ? 87.119  145.459 87.984  1.00 623.25 ? 23  DC  E N4    1 
ATOM   4717 C C5    . DC  B 2 23  ? 87.806  146.577 89.988  1.00 623.25 ? 23  DC  E C5    1 
ATOM   4718 C C6    . DC  B 2 23  ? 88.829  147.078 90.687  1.00 623.25 ? 23  DC  E C6    1 
ATOM   4719 P P     . DA  B 2 24  ? 93.217  151.051 93.000  1.00 636.90 ? 24  DA  E P     1 
ATOM   4720 O OP1   . DA  B 2 24  ? 94.080  151.158 94.197  1.00 636.90 ? 24  DA  E OP1   1 
ATOM   4721 O OP2   . DA  B 2 24  ? 91.856  151.634 93.060  1.00 636.90 ? 24  DA  E OP2   1 
ATOM   4722 O "O5'" . DA  B 2 24  ? 93.986  151.654 91.731  1.00 636.90 ? 24  DA  E "O5'" 1 
ATOM   4723 C "C5'" . DA  B 2 24  ? 95.259  151.143 91.364  1.00 636.90 ? 24  DA  E "C5'" 1 
ATOM   4724 C "C4'" . DA  B 2 24  ? 95.395  151.053 89.854  1.00 636.90 ? 24  DA  E "C4'" 1 
ATOM   4725 O "O4'" . DA  B 2 24  ? 94.236  150.392 89.277  1.00 636.90 ? 24  DA  E "O4'" 1 
ATOM   4726 C "C3'" . DA  B 2 24  ? 95.506  152.401 89.138  1.00 636.90 ? 24  DA  E "C3'" 1 
ATOM   4727 O "O3'" . DA  B 2 24  ? 96.334  152.240 88.027  1.00 636.90 ? 24  DA  E "O3'" 1 
ATOM   4728 C "C2'" . DA  B 2 24  ? 94.066  152.675 88.721  1.00 636.90 ? 24  DA  E "C2'" 1 
ATOM   4729 C "C1'" . DA  B 2 24  ? 93.570  151.268 88.392  1.00 636.90 ? 24  DA  E "C1'" 1 
ATOM   4730 N N9    . DA  B 2 24  ? 92.155  151.094 88.596  1.00 636.90 ? 24  DA  E N9    1 
ATOM   4731 C C8    . DA  B 2 24  ? 91.440  151.473 89.688  1.00 636.90 ? 24  DA  E C8    1 
ATOM   4732 N N7    . DA  B 2 24  ? 90.176  151.174 89.625  1.00 636.90 ? 24  DA  E N7    1 
ATOM   4733 C C5    . DA  B 2 24  ? 90.046  150.535 88.407  1.00 636.90 ? 24  DA  E C5    1 
ATOM   4734 C C6    . DA  B 2 24  ? 88.941  149.977 87.771  1.00 636.90 ? 24  DA  E C6    1 
ATOM   4735 N N6    . DA  B 2 24  ? 87.724  149.982 88.316  1.00 636.90 ? 24  DA  E N6    1 
ATOM   4736 N N1    . DA  B 2 24  ? 89.132  149.415 86.570  1.00 636.90 ? 24  DA  E N1    1 
ATOM   4737 C C2    . DA  B 2 24  ? 90.366  149.414 86.046  1.00 636.90 ? 24  DA  E C2    1 
ATOM   4738 N N3    . DA  B 2 24  ? 91.496  149.900 86.558  1.00 636.90 ? 24  DA  E N3    1 
ATOM   4739 C C4    . DA  B 2 24  ? 91.261  150.456 87.759  1.00 636.90 ? 24  DA  E C4    1 
ATOM   4740 P P     . DC  B 2 25  ? 96.897  153.503 87.225  1.00 704.27 ? 25  DC  E P     1 
ATOM   4741 O OP1   . DC  B 2 25  ? 98.369  153.433 87.407  1.00 704.27 ? 25  DC  E OP1   1 
ATOM   4742 O OP2   . DC  B 2 25  ? 96.139  154.705 87.661  1.00 704.27 ? 25  DC  E OP2   1 
ATOM   4743 O "O5'" . DC  B 2 25  ? 96.559  153.160 85.693  1.00 704.27 ? 25  DC  E "O5'" 1 
ATOM   4744 C "C5'" . DC  B 2 25  ? 95.388  152.422 85.375  1.00 704.27 ? 25  DC  E "C5'" 1 
ATOM   4745 C "C4'" . DC  B 2 25  ? 94.848  152.823 84.014  1.00 704.27 ? 25  DC  E "C4'" 1 
ATOM   4746 O "O4'" . DC  B 2 25  ? 93.451  152.437 83.909  1.00 704.27 ? 25  DC  E "O4'" 1 
ATOM   4747 C "C3'" . DC  B 2 25  ? 94.877  154.319 83.728  1.00 704.27 ? 25  DC  E "C3'" 1 
ATOM   4748 O "O3'" . DC  B 2 25  ? 94.998  154.541 82.337  1.00 704.27 ? 25  DC  E "O3'" 1 
ATOM   4749 C "C2'" . DC  B 2 25  ? 93.515  154.772 84.235  1.00 704.27 ? 25  DC  E "C2'" 1 
ATOM   4750 C "C1'" . DC  B 2 25  ? 92.634  153.592 83.831  1.00 704.27 ? 25  DC  E "C1'" 1 
ATOM   4751 N N1    . DC  B 2 25  ? 91.452  153.396 84.721  1.00 704.27 ? 25  DC  E N1    1 
ATOM   4752 C C2    . DC  B 2 25  ? 90.341  152.676 84.255  1.00 704.27 ? 25  DC  E C2    1 
ATOM   4753 O O2    . DC  B 2 25  ? 90.358  152.211 83.108  1.00 704.27 ? 25  DC  E O2    1 
ATOM   4754 N N3    . DC  B 2 25  ? 89.278  152.512 85.078  1.00 704.27 ? 25  DC  E N3    1 
ATOM   4755 C C4    . DC  B 2 25  ? 89.305  153.027 86.312  1.00 704.27 ? 25  DC  E C4    1 
ATOM   4756 N N4    . DC  B 2 25  ? 88.231  152.847 87.086  1.00 704.27 ? 25  DC  E N4    1 
ATOM   4757 C C5    . DC  B 2 25  ? 90.424  153.762 86.798  1.00 704.27 ? 25  DC  E C5    1 
ATOM   4758 C C6    . DC  B 2 25  ? 91.465  153.917 85.979  1.00 704.27 ? 25  DC  E C6    1 
ATOM   4759 P P     . DA  B 2 26  ? 96.236  155.384 81.762  1.00 822.48 ? 26  DA  E P     1 
ATOM   4760 O OP1   . DA  B 2 26  ? 97.322  154.415 81.486  1.00 822.48 ? 26  DA  E OP1   1 
ATOM   4761 O OP2   . DA  B 2 26  ? 96.457  156.526 82.681  1.00 822.48 ? 26  DA  E OP2   1 
ATOM   4762 O "O5'" . DA  B 2 26  ? 95.689  155.963 80.373  1.00 822.48 ? 26  DA  E "O5'" 1 
ATOM   4763 C "C5'" . DA  B 2 26  ? 95.416  155.076 79.291  1.00 822.48 ? 26  DA  E "C5'" 1 
ATOM   4764 C "C4'" . DA  B 2 26  ? 93.980  155.219 78.821  1.00 822.48 ? 26  DA  E "C4'" 1 
ATOM   4765 O "O4'" . DA  B 2 26  ? 93.093  154.954 79.918  1.00 822.48 ? 26  DA  E "O4'" 1 
ATOM   4766 C "C3'" . DA  B 2 26  ? 93.605  156.612 78.333  1.00 822.48 ? 26  DA  E "C3'" 1 
ATOM   4767 O "O3'" . DA  B 2 26  ? 93.703  156.667 76.912  1.00 822.48 ? 26  DA  E "O3'" 1 
ATOM   4768 C "C2'" . DA  B 2 26  ? 92.154  156.810 78.807  1.00 822.48 ? 26  DA  E "C2'" 1 
ATOM   4769 C "C1'" . DA  B 2 26  ? 91.865  155.578 79.668  1.00 822.48 ? 26  DA  E "C1'" 1 
ATOM   4770 N N9    . DA  B 2 26  ? 91.242  155.905 80.946  1.00 822.48 ? 26  DA  E N9    1 
ATOM   4771 C C8    . DA  B 2 26  ? 91.777  156.665 81.949  1.00 822.48 ? 26  DA  E C8    1 
ATOM   4772 N N7    . DA  B 2 26  ? 90.990  156.795 82.992  1.00 822.48 ? 26  DA  E N7    1 
ATOM   4773 C C5    . DA  B 2 26  ? 89.861  156.071 82.646  1.00 822.48 ? 26  DA  E C5    1 
ATOM   4774 C C6    . DA  B 2 26  ? 88.653  155.816 83.325  1.00 822.48 ? 26  DA  E C6    1 
ATOM   4775 N N6    . DA  B 2 26  ? 88.381  156.287 84.547  1.00 822.48 ? 26  DA  E N6    1 
ATOM   4776 N N1    . DA  B 2 26  ? 87.732  155.053 82.696  1.00 822.48 ? 26  DA  E N1    1 
ATOM   4777 C C2    . DA  B 2 26  ? 88.010  154.586 81.473  1.00 822.48 ? 26  DA  E C2    1 
ATOM   4778 N N3    . DA  B 2 26  ? 89.105  154.758 80.738  1.00 822.48 ? 26  DA  E N3    1 
ATOM   4779 C C4    . DA  B 2 26  ? 90.000  155.516 81.388  1.00 822.48 ? 26  DA  E C4    1 
ATOM   4780 P P     . DG  B 2 27  ? 93.260  157.991 76.114  1.00 881.22 ? 27  DG  E P     1 
ATOM   4781 O OP1   . DG  B 2 27  ? 93.972  157.994 74.818  1.00 881.22 ? 27  DG  E OP1   1 
ATOM   4782 O OP2   . DG  B 2 27  ? 93.407  159.146 77.029  1.00 881.22 ? 27  DG  E OP2   1 
ATOM   4783 O "O5'" . DG  B 2 27  ? 91.698  157.774 75.843  1.00 881.22 ? 27  DG  E "O5'" 1 
ATOM   4784 C "C5'" . DG  B 2 27  ? 91.253  156.646 75.095  1.00 881.22 ? 27  DG  E "C5'" 1 
ATOM   4785 C "C4'" . DG  B 2 27  ? 89.740  156.521 75.140  1.00 881.22 ? 27  DG  E "C4'" 1 
ATOM   4786 O "O4'" . DG  B 2 27  ? 89.327  156.018 76.427  1.00 881.22 ? 27  DG  E "O4'" 1 
ATOM   4787 C "C3'" . DG  B 2 27  ? 88.979  157.823 74.986  1.00 881.22 ? 27  DG  E "C3'" 1 
ATOM   4788 O "O3'" . DG  B 2 27  ? 88.847  158.148 73.608  1.00 881.22 ? 27  DG  E "O3'" 1 
ATOM   4789 C "C2'" . DG  B 2 27  ? 87.629  157.476 75.612  1.00 881.22 ? 27  DG  E "C2'" 1 
ATOM   4790 C "C1'" . DG  B 2 27  ? 88.012  156.473 76.709  1.00 881.22 ? 27  DG  E "C1'" 1 
ATOM   4791 N N9    . DG  B 2 27  ? 87.994  157.043 78.054  1.00 881.22 ? 27  DG  E N9    1 
ATOM   4792 C C8    . DG  B 2 27  ? 88.935  157.870 78.616  1.00 881.22 ? 27  DG  E C8    1 
ATOM   4793 N N7    . DG  B 2 27  ? 88.651  158.226 79.837  1.00 881.22 ? 27  DG  E N7    1 
ATOM   4794 C C5    . DG  B 2 27  ? 87.442  157.596 80.103  1.00 881.22 ? 27  DG  E C5    1 
ATOM   4795 C C6    . DG  B 2 27  ? 86.642  157.614 81.271  1.00 881.22 ? 27  DG  E C6    1 
ATOM   4796 O O6    . DG  B 2 27  ? 86.855  158.206 82.337  1.00 881.22 ? 27  DG  E O6    1 
ATOM   4797 N N1    . DG  B 2 27  ? 85.495  156.839 81.122  1.00 881.22 ? 27  DG  E N1    1 
ATOM   4798 C C2    . DG  B 2 27  ? 85.162  156.139 79.986  1.00 881.22 ? 27  DG  E C2    1 
ATOM   4799 N N2    . DG  B 2 27  ? 84.012  155.450 80.029  1.00 881.22 ? 27  DG  E N2    1 
ATOM   4800 N N3    . DG  B 2 27  ? 85.902  156.116 78.885  1.00 881.22 ? 27  DG  E N3    1 
ATOM   4801 C C4    . DG  B 2 27  ? 87.024  156.864 79.015  1.00 881.22 ? 27  DG  E C4    1 
ATOM   4802 O "O3'" . DA  C 3 2   ? 81.149  164.631 86.425  1.00 1033.9 ? 2   DA  F "O3'" 1 
ATOM   4803 P P     . DC  C 3 3   ? 81.987  164.743 87.792  1.00 1033.9 ? 3   DC  F P     1 
ATOM   4804 O OP1   . DC  C 3 3   ? 81.309  165.737 88.653  1.00 1033.9 ? 3   DC  F OP1   1 
ATOM   4805 O OP2   . DC  C 3 3   ? 83.409  164.931 87.431  1.00 1033.9 ? 3   DC  F OP2   1 
ATOM   4806 O "O5'" . DC  C 3 3   ? 81.835  163.295 88.455  1.00 1033.9 ? 3   DC  F "O5'" 1 
ATOM   4807 C "C5'" . DC  C 3 3   ? 80.544  162.796 88.790  1.00 1033.9 ? 3   DC  F "C5'" 1 
ATOM   4808 C "C4'" . DC  C 3 3   ? 80.115  161.710 87.820  1.00 1033.9 ? 3   DC  F "C4'" 1 
ATOM   4809 O "O4'" . DC  C 3 3   ? 81.031  161.678 86.693  1.00 1033.9 ? 3   DC  F "O4'" 1 
ATOM   4810 C "C3'" . DC  C 3 3   ? 80.108  160.297 88.398  1.00 1033.9 ? 3   DC  F "C3'" 1 
ATOM   4811 O "O3'" . DC  C 3 3   ? 79.010  159.560 87.874  1.00 1033.9 ? 3   DC  F "O3'" 1 
ATOM   4812 C "C2'" . DC  C 3 3   ? 81.442  159.726 87.932  1.00 1033.9 ? 3   DC  F "C2'" 1 
ATOM   4813 C "C1'" . DC  C 3 3   ? 81.604  160.393 86.572  1.00 1033.9 ? 3   DC  F "C1'" 1 
ATOM   4814 N N1    . DC  C 3 3   ? 83.026  160.546 86.154  1.00 1033.9 ? 3   DC  F N1    1 
ATOM   4815 C C2    . DC  C 3 3   ? 83.442  160.054 84.912  1.00 1033.9 ? 3   DC  F C2    1 
ATOM   4816 O O2    . DC  C 3 3   ? 82.618  159.499 84.176  1.00 1033.9 ? 3   DC  F O2    1 
ATOM   4817 N N3    . DC  C 3 3   ? 84.740  160.201 84.550  1.00 1033.9 ? 3   DC  F N3    1 
ATOM   4818 C C4    . DC  C 3 3   ? 85.599  160.808 85.374  1.00 1033.9 ? 3   DC  F C4    1 
ATOM   4819 N N4    . DC  C 3 3   ? 86.869  160.930 84.973  1.00 1033.9 ? 3   DC  F N4    1 
ATOM   4820 C C5    . DC  C 3 3   ? 85.193  161.314 86.643  1.00 1033.9 ? 3   DC  F C5    1 
ATOM   4821 C C6    . DC  C 3 3   ? 83.911  161.162 86.989  1.00 1033.9 ? 3   DC  F C6    1 
ATOM   4822 P P     . DT  C 3 4   ? 78.489  158.240 88.630  1.00 891.95 ? 4   DT  F P     1 
ATOM   4823 O OP1   . DT  C 3 4   ? 77.017  158.198 88.485  1.00 891.95 ? 4   DT  F OP1   1 
ATOM   4824 O OP2   . DT  C 3 4   ? 79.093  158.228 89.980  1.00 891.95 ? 4   DT  F OP2   1 
ATOM   4825 O "O5'" . DT  C 3 4   ? 79.127  157.036 87.792  1.00 891.95 ? 4   DT  F "O5'" 1 
ATOM   4826 C "C5'" . DT  C 3 4   ? 78.712  156.805 86.450  1.00 891.95 ? 4   DT  F "C5'" 1 
ATOM   4827 C "C4'" . DT  C 3 4   ? 79.529  155.696 85.806  1.00 891.95 ? 4   DT  F "C4'" 1 
ATOM   4828 O "O4'" . DT  C 3 4   ? 80.832  156.205 85.412  1.00 891.95 ? 4   DT  F "O4'" 1 
ATOM   4829 C "C3'" . DT  C 3 4   ? 79.798  154.476 86.695  1.00 891.95 ? 4   DT  F "C3'" 1 
ATOM   4830 O "O3'" . DT  C 3 4   ? 79.553  153.284 85.962  1.00 891.95 ? 4   DT  F "O3'" 1 
ATOM   4831 C "C2'" . DT  C 3 4   ? 81.279  154.616 87.049  1.00 891.95 ? 4   DT  F "C2'" 1 
ATOM   4832 C "C1'" . DT  C 3 4   ? 81.821  155.282 85.795  1.00 891.95 ? 4   DT  F "C1'" 1 
ATOM   4833 N N1    . DT  C 3 4   ? 83.104  156.013 86.010  1.00 891.95 ? 4   DT  F N1    1 
ATOM   4834 C C2    . DT  C 3 4   ? 84.052  156.015 85.013  1.00 891.95 ? 4   DT  F C2    1 
ATOM   4835 O O2    . DT  C 3 4   ? 83.903  155.448 83.945  1.00 891.95 ? 4   DT  F O2    1 
ATOM   4836 N N3    . DT  C 3 4   ? 85.191  156.714 85.311  1.00 891.95 ? 4   DT  F N3    1 
ATOM   4837 C C4    . DT  C 3 4   ? 85.472  157.394 86.483  1.00 891.95 ? 4   DT  F C4    1 
ATOM   4838 O O4    . DT  C 3 4   ? 86.528  157.992 86.657  1.00 891.95 ? 4   DT  F O4    1 
ATOM   4839 C C5    . DT  C 3 4   ? 84.435  157.348 87.486  1.00 891.95 ? 4   DT  F C5    1 
ATOM   4840 C C7    . DT  C 3 4   ? 84.626  158.047 88.800  1.00 891.95 ? 4   DT  F C7    1 
ATOM   4841 C C6    . DT  C 3 4   ? 83.316  156.667 87.206  1.00 891.95 ? 4   DT  F C6    1 
ATOM   4842 P P     . DG  C 3 5   ? 78.949  151.990 86.698  1.00 679.59 ? 5   DG  F P     1 
ATOM   4843 O OP1   . DG  C 3 5   ? 77.517  152.253 86.959  1.00 679.59 ? 5   DG  F OP1   1 
ATOM   4844 O OP2   . DG  C 3 5   ? 79.850  151.654 87.824  1.00 679.59 ? 5   DG  F OP2   1 
ATOM   4845 O "O5'" . DG  C 3 5   ? 79.081  150.831 85.601  1.00 679.59 ? 5   DG  F "O5'" 1 
ATOM   4846 C "C5'" . DG  C 3 5   ? 78.378  150.932 84.364  1.00 679.59 ? 5   DG  F "C5'" 1 
ATOM   4847 C "C4'" . DG  C 3 5   ? 79.316  150.716 83.182  1.00 679.59 ? 5   DG  F "C4'" 1 
ATOM   4848 O "O4'" . DG  C 3 5   ? 80.470  151.594 83.311  1.00 679.59 ? 5   DG  F "O4'" 1 
ATOM   4849 C "C3'" . DG  C 3 5   ? 79.891  149.303 83.044  1.00 679.59 ? 5   DG  F "C3'" 1 
ATOM   4850 O "O3'" . DG  C 3 5   ? 80.076  148.992 81.659  1.00 679.59 ? 5   DG  F "O3'" 1 
ATOM   4851 C "C2'" . DG  C 3 5   ? 81.229  149.435 83.760  1.00 679.59 ? 5   DG  F "C2'" 1 
ATOM   4852 C "C1'" . DG  C 3 5   ? 81.647  150.812 83.273  1.00 679.59 ? 5   DG  F "C1'" 1 
ATOM   4853 N N9    . DG  C 3 5   ? 82.667  151.450 84.095  1.00 679.59 ? 5   DG  F N9    1 
ATOM   4854 C C8    . DG  C 3 5   ? 82.557  151.834 85.406  1.00 679.59 ? 5   DG  F C8    1 
ATOM   4855 N N7    . DG  C 3 5   ? 83.639  152.386 85.878  1.00 679.59 ? 5   DG  F N7    1 
ATOM   4856 C C5    . DG  C 3 5   ? 84.524  152.370 84.807  1.00 679.59 ? 5   DG  F C5    1 
ATOM   4857 C C6    . DG  C 3 5   ? 85.854  152.831 84.717  1.00 679.59 ? 5   DG  F C6    1 
ATOM   4858 O O6    . DG  C 3 5   ? 86.531  153.373 85.594  1.00 679.59 ? 5   DG  F O6    1 
ATOM   4859 N N1    . DG  C 3 5   ? 86.392  152.620 83.447  1.00 679.59 ? 5   DG  F N1    1 
ATOM   4860 C C2    . DG  C 3 5   ? 85.721  152.037 82.401  1.00 679.59 ? 5   DG  F C2    1 
ATOM   4861 N N2    . DG  C 3 5   ? 86.397  151.912 81.249  1.00 679.59 ? 5   DG  F N2    1 
ATOM   4862 N N3    . DG  C 3 5   ? 84.473  151.600 82.475  1.00 679.59 ? 5   DG  F N3    1 
ATOM   4863 C C4    . DG  C 3 5   ? 83.940  151.798 83.703  1.00 679.59 ? 5   DG  F C4    1 
ATOM   4864 P P     . DT  C 3 6   ? 80.588  147.514 81.278  1.00 658.97 ? 6   DT  F P     1 
ATOM   4865 O OP1   . DT  C 3 6   ? 79.541  146.776 80.466  1.00 658.97 ? 6   DT  F OP1   1 
ATOM   4866 O OP2   . DT  C 3 6   ? 81.139  146.714 82.448  1.00 658.97 ? 6   DT  F OP2   1 
ATOM   4867 O "O5'" . DT  C 3 6   ? 81.832  147.813 80.292  1.00 658.97 ? 6   DT  F "O5'" 1 
ATOM   4868 C "C5'" . DT  C 3 6   ? 82.902  148.674 80.757  1.00 658.97 ? 6   DT  F "C5'" 1 
ATOM   4869 C "C4'" . DT  C 3 6   ? 84.227  148.138 80.274  1.00 658.97 ? 6   DT  F "C4'" 1 
ATOM   4870 O "O4'" . DT  C 3 6   ? 85.298  148.757 81.020  1.00 658.97 ? 6   DT  F "O4'" 1 
ATOM   4871 C "C3'" . DT  C 3 6   ? 84.425  146.641 80.470  1.00 658.97 ? 6   DT  F "C3'" 1 
ATOM   4872 O "O3'" . DT  C 3 6   ? 85.418  146.159 79.571  1.00 658.97 ? 6   DT  F "O3'" 1 
ATOM   4873 C "C2'" . DT  C 3 6   ? 84.945  146.589 81.896  1.00 658.97 ? 6   DT  F "C2'" 1 
ATOM   4874 C "C1'" . DT  C 3 6   ? 85.817  147.837 81.973  1.00 658.97 ? 6   DT  F "C1'" 1 
ATOM   4875 N N1    . DT  C 3 6   ? 85.793  148.505 83.286  1.00 658.97 ? 6   DT  F N1    1 
ATOM   4876 C C2    . DT  C 3 6   ? 86.864  149.300 83.637  1.00 658.97 ? 6   DT  F C2    1 
ATOM   4877 O O2    . DT  C 3 6   ? 87.830  149.475 82.907  1.00 658.97 ? 6   DT  F O2    1 
ATOM   4878 N N3    . DT  C 3 6   ? 86.762  149.888 84.873  1.00 658.97 ? 6   DT  F N3    1 
ATOM   4879 C C4    . DT  C 3 6   ? 85.722  149.756 85.773  1.00 658.97 ? 6   DT  F C4    1 
ATOM   4880 O O4    . DT  C 3 6   ? 85.763  150.353 86.850  1.00 658.97 ? 6   DT  F O4    1 
ATOM   4881 C C5    . DT  C 3 6   ? 84.632  148.912 85.339  1.00 658.97 ? 6   DT  F C5    1 
ATOM   4882 C C7    . DT  C 3 6   ? 83.465  148.719 86.261  1.00 658.97 ? 6   DT  F C7    1 
ATOM   4883 C C6    . DT  C 3 6   ? 84.718  148.333 84.133  1.00 658.97 ? 6   DT  F C6    1 
ATOM   4884 P P     . DG  C 3 7   ? 85.273  144.627 79.100  1.00 675.65 ? 7   DG  F P     1 
ATOM   4885 O OP1   . DG  C 3 7   ? 84.404  144.588 77.901  1.00 675.65 ? 7   DG  F OP1   1 
ATOM   4886 O OP2   . DG  C 3 7   ? 84.957  143.769 80.266  1.00 675.65 ? 7   DG  F OP2   1 
ATOM   4887 O "O5'" . DG  C 3 7   ? 86.785  144.368 78.649  1.00 675.65 ? 7   DG  F "O5'" 1 
ATOM   4888 C "C5'" . DG  C 3 7   ? 87.301  145.034 77.492  1.00 675.65 ? 7   DG  F "C5'" 1 
ATOM   4889 C "C4'" . DG  C 3 7   ? 88.778  145.360 77.650  1.00 675.65 ? 7   DG  F "C4'" 1 
ATOM   4890 O "O4'" . DG  C 3 7   ? 88.983  146.078 78.893  1.00 675.65 ? 7   DG  F "O4'" 1 
ATOM   4891 C "C3'" . DG  C 3 7   ? 89.710  144.157 77.709  1.00 675.65 ? 7   DG  F "C3'" 1 
ATOM   4892 O "O3'" . DG  C 3 7   ? 90.975  144.497 77.154  1.00 675.65 ? 7   DG  F "O3'" 1 
ATOM   4893 C "C2'" . DG  C 3 7   ? 89.812  143.890 79.205  1.00 675.65 ? 7   DG  F "C2'" 1 
ATOM   4894 C "C1'" . DG  C 3 7   ? 89.771  145.305 79.776  1.00 675.65 ? 7   DG  F "C1'" 1 
ATOM   4895 N N9    . DG  C 3 7   ? 89.170  145.368 81.103  1.00 675.65 ? 7   DG  F N9    1 
ATOM   4896 C C8    . DG  C 3 7   ? 87.948  144.870 81.482  1.00 675.65 ? 7   DG  F C8    1 
ATOM   4897 N N7    . DG  C 3 7   ? 87.674  145.069 82.739  1.00 675.65 ? 7   DG  F N7    1 
ATOM   4898 C C5    . DG  C 3 7   ? 88.785  145.743 83.227  1.00 675.65 ? 7   DG  F C5    1 
ATOM   4899 C C6    . DG  C 3 7   ? 89.056  146.224 84.525  1.00 675.65 ? 7   DG  F C6    1 
ATOM   4900 O O6    . DG  C 3 7   ? 88.346  146.143 85.535  1.00 675.65 ? 7   DG  F O6    1 
ATOM   4901 N N1    . DG  C 3 7   ? 90.301  146.839 84.594  1.00 675.65 ? 7   DG  F N1    1 
ATOM   4902 C C2    . DG  C 3 7   ? 91.164  146.990 83.537  1.00 675.65 ? 7   DG  F C2    1 
ATOM   4903 N N2    . DG  C 3 7   ? 92.318  147.620 83.797  1.00 675.65 ? 7   DG  F N2    1 
ATOM   4904 N N3    . DG  C 3 7   ? 90.922  146.544 82.313  1.00 675.65 ? 7   DG  F N3    1 
ATOM   4905 C C4    . DG  C 3 7   ? 89.715  145.933 82.231  1.00 675.65 ? 7   DG  F C4    1 
ATOM   4906 P P     . DA  C 3 8   ? 92.179  143.431 77.153  1.00 633.79 ? 8   DA  F P     1 
ATOM   4907 O OP1   . DA  C 3 8   ? 93.077  143.779 76.030  1.00 633.79 ? 8   DA  F OP1   1 
ATOM   4908 O OP2   . DA  C 3 8   ? 91.597  142.071 77.232  1.00 633.79 ? 8   DA  F OP2   1 
ATOM   4909 O "O5'" . DA  C 3 8   ? 92.948  143.718 78.527  1.00 633.79 ? 8   DA  F "O5'" 1 
ATOM   4910 C "C5'" . DA  C 3 8   ? 93.496  145.007 78.777  1.00 633.79 ? 8   DA  F "C5'" 1 
ATOM   4911 C "C4'" . DA  C 3 8   ? 94.256  145.032 80.095  1.00 633.79 ? 8   DA  F "C4'" 1 
ATOM   4912 O "O4'" . DA  C 3 8   ? 93.320  145.135 81.199  1.00 633.79 ? 8   DA  F "O4'" 1 
ATOM   4913 C "C3'" . DA  C 3 8   ? 95.117  143.797 80.374  1.00 633.79 ? 8   DA  F "C3'" 1 
ATOM   4914 O "O3'" . DA  C 3 8   ? 96.384  144.197 80.869  1.00 633.79 ? 8   DA  F "O3'" 1 
ATOM   4915 C "C2'" . DA  C 3 8   ? 94.316  143.043 81.435  1.00 633.79 ? 8   DA  F "C2'" 1 
ATOM   4916 C "C1'" . DA  C 3 8   ? 93.655  144.187 82.184  1.00 633.79 ? 8   DA  F "C1'" 1 
ATOM   4917 N N9    . DA  C 3 8   ? 92.437  143.801 82.883  1.00 633.79 ? 8   DA  F N9    1 
ATOM   4918 C C8    . DA  C 3 8   ? 91.358  143.145 82.362  1.00 633.79 ? 8   DA  F C8    1 
ATOM   4919 N N7    . DA  C 3 8   ? 90.399  142.932 83.230  1.00 633.79 ? 8   DA  F N7    1 
ATOM   4920 C C5    . DA  C 3 8   ? 90.884  143.490 84.401  1.00 633.79 ? 8   DA  F C5    1 
ATOM   4921 C C6    . DA  C 3 8   ? 90.343  143.597 85.695  1.00 633.79 ? 8   DA  F C6    1 
ATOM   4922 N N6    . DA  C 3 8   ? 89.141  143.120 86.031  1.00 633.79 ? 8   DA  F N6    1 
ATOM   4923 N N1    . DA  C 3 8   ? 91.090  144.212 86.634  1.00 633.79 ? 8   DA  F N1    1 
ATOM   4924 C C2    . DA  C 3 8   ? 92.291  144.687 86.292  1.00 633.79 ? 8   DA  F C2    1 
ATOM   4925 N N3    . DA  C 3 8   ? 92.903  144.649 85.113  1.00 633.79 ? 8   DA  F N3    1 
ATOM   4926 C C4    . DA  C 3 8   ? 92.139  144.029 84.204  1.00 633.79 ? 8   DA  F C4    1 
ATOM   4927 P P     . DG  C 3 9   ? 97.659  143.235 80.710  1.00 562.60 ? 9   DG  F P     1 
ATOM   4928 O OP1   . DG  C 3 9   ? 98.599  143.875 79.763  1.00 562.60 ? 9   DG  F OP1   1 
ATOM   4929 O OP2   . DG  C 3 9   ? 97.160  141.867 80.441  1.00 562.60 ? 9   DG  F OP2   1 
ATOM   4930 O "O5'" . DG  C 3 9   ? 98.310  143.229 82.170  1.00 562.60 ? 9   DG  F "O5'" 1 
ATOM   4931 C "C5'" . DG  C 3 9   ? 97.989  144.261 83.097  1.00 562.60 ? 9   DG  F "C5'" 1 
ATOM   4932 C "C4'" . DG  C 3 9   ? 97.762  143.679 84.478  1.00 562.60 ? 9   DG  F "C4'" 1 
ATOM   4933 O "O4'" . DG  C 3 9   ? 96.355  143.448 84.679  1.00 562.60 ? 9   DG  F "O4'" 1 
ATOM   4934 C "C3'" . DG  C 3 9   ? 98.436  142.326 84.717  1.00 562.60 ? 9   DG  F "C3'" 1 
ATOM   4935 O "O3'" . DG  C 3 9   ? 99.633  142.452 85.543  1.00 562.60 ? 9   DG  F "O3'" 1 
ATOM   4936 C "C2'" . DG  C 3 9   ? 97.350  141.445 85.367  1.00 562.60 ? 9   DG  F "C2'" 1 
ATOM   4937 C "C1'" . DG  C 3 9   ? 96.214  142.430 85.632  1.00 562.60 ? 9   DG  F "C1'" 1 
ATOM   4938 N N9    . DG  C 3 9   ? 94.882  141.848 85.510  1.00 562.60 ? 9   DG  F N9    1 
ATOM   4939 C C8    . DG  C 3 9   ? 94.339  141.247 84.402  1.00 562.60 ? 9   DG  F C8    1 
ATOM   4940 N N7    . DG  C 3 9   ? 93.123  140.820 84.586  1.00 562.60 ? 9   DG  F N7    1 
ATOM   4941 C C5    . DG  C 3 9   ? 92.840  141.160 85.903  1.00 562.60 ? 9   DG  F C5    1 
ATOM   4942 C C6    . DG  C 3 9   ? 91.670  140.947 86.664  1.00 562.60 ? 9   DG  F C6    1 
ATOM   4943 O O6    . DG  C 3 9   ? 90.617  140.406 86.312  1.00 562.60 ? 9   DG  F O6    1 
ATOM   4944 N N1    . DG  C 3 9   ? 91.798  141.449 87.957  1.00 562.60 ? 9   DG  F N1    1 
ATOM   4945 C C2    . DG  C 3 9   ? 92.920  142.073 88.451  1.00 562.60 ? 9   DG  F C2    1 
ATOM   4946 N N2    . DG  C 3 9   ? 92.856  142.486 89.724  1.00 562.60 ? 9   DG  F N2    1 
ATOM   4947 N N3    . DG  C 3 9   ? 94.026  142.275 87.746  1.00 562.60 ? 9   DG  F N3    1 
ATOM   4948 C C4    . DG  C 3 9   ? 93.913  141.794 86.484  1.00 562.60 ? 9   DG  F C4    1 
ATOM   4949 P P     . DG  C 3 10  ? 99.732  143.459 86.800  1.00 515.37 ? 10  DG  F P     1 
ATOM   4950 O OP1   . DG  C 3 10  ? 99.820  144.858 86.325  1.00 515.37 ? 10  DG  F OP1   1 
ATOM   4951 O OP2   . DG  C 3 10  ? 100.832 142.944 87.644  1.00 515.37 ? 10  DG  F OP2   1 
ATOM   4952 O "O5'" . DG  C 3 10  ? 98.358  143.256 87.593  1.00 515.37 ? 10  DG  F "O5'" 1 
ATOM   4953 C "C5'" . DG  C 3 10  ? 98.228  143.699 88.934  1.00 515.37 ? 10  DG  F "C5'" 1 
ATOM   4954 C "C4'" . DG  C 3 10  ? 97.986  142.525 89.868  1.00 515.37 ? 10  DG  F "C4'" 1 
ATOM   4955 O "O4'" . DG  C 3 10  ? 96.715  141.900 89.554  1.00 515.37 ? 10  DG  F "O4'" 1 
ATOM   4956 C "C3'" . DG  C 3 10  ? 99.038  141.410 89.792  1.00 515.37 ? 10  DG  F "C3'" 1 
ATOM   4957 O "O3'" . DG  C 3 10  ? 99.614  141.196 91.070  1.00 515.37 ? 10  DG  F "O3'" 1 
ATOM   4958 C "C2'" . DG  C 3 10  ? 98.255  140.183 89.313  1.00 515.37 ? 10  DG  F "C2'" 1 
ATOM   4959 C "C1'" . DG  C 3 10  ? 96.842  140.518 89.754  1.00 515.37 ? 10  DG  F "C1'" 1 
ATOM   4960 N N9    . DG  C 3 10  ? 95.811  139.829 88.981  1.00 515.37 ? 10  DG  F N9    1 
ATOM   4961 C C8    . DG  C 3 10  ? 95.872  139.473 87.657  1.00 515.37 ? 10  DG  F C8    1 
ATOM   4962 N N7    . DG  C 3 10  ? 94.804  138.858 87.234  1.00 515.37 ? 10  DG  F N7    1 
ATOM   4963 C C5    . DG  C 3 10  ? 93.983  138.799 88.352  1.00 515.37 ? 10  DG  F C5    1 
ATOM   4964 C C6    . DG  C 3 10  ? 92.694  138.243 88.503  1.00 515.37 ? 10  DG  F C6    1 
ATOM   4965 O O6    . DG  C 3 10  ? 91.998  137.676 87.648  1.00 515.37 ? 10  DG  F O6    1 
ATOM   4966 N N1    . DG  C 3 10  ? 92.217  138.393 89.802  1.00 515.37 ? 10  DG  F N1    1 
ATOM   4967 C C2    . DG  C 3 10  ? 92.904  139.003 90.826  1.00 515.37 ? 10  DG  F C2    1 
ATOM   4968 N N2    . DG  C 3 10  ? 92.281  139.054 92.012  1.00 515.37 ? 10  DG  F N2    1 
ATOM   4969 N N3    . DG  C 3 10  ? 94.115  139.527 90.697  1.00 515.37 ? 10  DG  F N3    1 
ATOM   4970 C C4    . DG  C 3 10  ? 94.591  139.387 89.437  1.00 515.37 ? 10  DG  F C4    1 
ATOM   4971 P P     . DC  C 3 11  ? 101.154 140.753 91.195  1.00 531.56 ? 11  DC  F P     1 
ATOM   4972 O OP1   . DC  C 3 11  ? 101.913 141.911 91.717  1.00 531.56 ? 11  DC  F OP1   1 
ATOM   4973 O OP2   . DC  C 3 11  ? 101.546 140.137 89.908  1.00 531.56 ? 11  DC  F OP2   1 
ATOM   4974 O "O5'" . DC  C 3 11  ? 101.133 139.601 92.302  1.00 531.56 ? 11  DC  F "O5'" 1 
ATOM   4975 C "C5'" . DC  C 3 11  ? 100.316 138.451 92.114  1.00 531.56 ? 11  DC  F "C5'" 1 
ATOM   4976 C "C4'" . DC  C 3 11  ? 99.055  138.539 92.954  1.00 531.56 ? 11  DC  F "C4'" 1 
ATOM   4977 O "O4'" . DC  C 3 11  ? 97.892  138.530 92.081  1.00 531.56 ? 11  DC  F "O4'" 1 
ATOM   4978 C "C3'" . DC  C 3 11  ? 98.846  137.377 93.920  1.00 531.56 ? 11  DC  F "C3'" 1 
ATOM   4979 O "O3'" . DC  C 3 11  ? 98.129  137.823 95.068  1.00 531.56 ? 11  DC  F "O3'" 1 
ATOM   4980 C "C2'" . DC  C 3 11  ? 98.009  136.422 93.082  1.00 531.56 ? 11  DC  F "C2'" 1 
ATOM   4981 C "C1'" . DC  C 3 11  ? 97.089  137.405 92.375  1.00 531.56 ? 11  DC  F "C1'" 1 
ATOM   4982 N N1    . DC  C 3 11  ? 96.514  136.879 91.109  1.00 531.56 ? 11  DC  F N1    1 
ATOM   4983 C C2    . DC  C 3 11  ? 95.174  136.481 91.073  1.00 531.56 ? 11  DC  F C2    1 
ATOM   4984 O O2    . DC  C 3 11  ? 94.489  136.575 92.099  1.00 531.56 ? 11  DC  F O2    1 
ATOM   4985 N N3    . DC  C 3 11  ? 94.663  136.000 89.912  1.00 531.56 ? 11  DC  F N3    1 
ATOM   4986 C C4    . DC  C 3 11  ? 95.435  135.913 88.829  1.00 531.56 ? 11  DC  F C4    1 
ATOM   4987 N N4    . DC  C 3 11  ? 94.888  135.435 87.708  1.00 531.56 ? 11  DC  F N4    1 
ATOM   4988 C C5    . DC  C 3 11  ? 96.804  136.314 88.846  1.00 531.56 ? 11  DC  F C5    1 
ATOM   4989 C C6    . DC  C 3 11  ? 97.296  136.784 89.997  1.00 531.56 ? 11  DC  F C6    1 
ATOM   4990 P P     . DA  C 3 12  ? 98.178  136.976 96.434  1.00 599.86 ? 12  DA  F P     1 
ATOM   4991 O OP1   . DA  C 3 12  ? 98.766  137.844 97.477  1.00 599.86 ? 12  DA  F OP1   1 
ATOM   4992 O OP2   . DA  C 3 12  ? 98.798  135.666 96.131  1.00 599.86 ? 12  DA  F OP2   1 
ATOM   4993 O "O5'" . DA  C 3 12  ? 96.639  136.720 96.790  1.00 599.86 ? 12  DA  F "O5'" 1 
ATOM   4994 C "C5'" . DA  C 3 12  ? 95.745  136.258 95.787  1.00 599.86 ? 12  DA  F "C5'" 1 
ATOM   4995 C "C4'" . DA  C 3 12  ? 94.773  135.239 96.351  1.00 599.86 ? 12  DA  F "C4'" 1 
ATOM   4996 O "O4'" . DA  C 3 12  ? 94.029  134.645 95.258  1.00 599.86 ? 12  DA  F "O4'" 1 
ATOM   4997 C "C3'" . DA  C 3 12  ? 95.419  134.066 97.063  1.00 599.86 ? 12  DA  F "C3'" 1 
ATOM   4998 O "O3'" . DA  C 3 12  ? 94.491  133.469 97.963  1.00 599.86 ? 12  DA  F "O3'" 1 
ATOM   4999 C "C2'" . DA  C 3 12  ? 95.738  133.137 95.902  1.00 599.86 ? 12  DA  F "C2'" 1 
ATOM   5000 C "C1'" . DA  C 3 12  ? 94.522  133.341 94.995  1.00 599.86 ? 12  DA  F "C1'" 1 
ATOM   5001 N N9    . DA  C 3 12  ? 94.847  133.244 93.577  1.00 599.86 ? 12  DA  F N9    1 
ATOM   5002 C C8    . DA  C 3 12  ? 95.935  133.779 92.947  1.00 599.86 ? 12  DA  F C8    1 
ATOM   5003 N N7    . DA  C 3 12  ? 95.981  133.528 91.663  1.00 599.86 ? 12  DA  F N7    1 
ATOM   5004 C C5    . DA  C 3 12  ? 94.846  132.772 91.432  1.00 599.86 ? 12  DA  F C5    1 
ATOM   5005 C C6    . DA  C 3 12  ? 94.322  132.189 90.267  1.00 599.86 ? 12  DA  F C6    1 
ATOM   5006 N N6    . DA  C 3 12  ? 94.908  132.294 89.071  1.00 599.86 ? 12  DA  F N6    1 
ATOM   5007 N N1    . DA  C 3 12  ? 93.169  131.498 90.376  1.00 599.86 ? 12  DA  F N1    1 
ATOM   5008 C C2    . DA  C 3 12  ? 92.584  131.404 91.575  1.00 599.86 ? 12  DA  F C2    1 
ATOM   5009 N N3    . DA  C 3 12  ? 92.988  131.901 92.744  1.00 599.86 ? 12  DA  F N3    1 
ATOM   5010 C C4    . DA  C 3 12  ? 94.135  132.585 92.602  1.00 599.86 ? 12  DA  F C4    1 
ATOM   5011 P P     . DT  C 3 13  ? 95.014  132.706 99.277  1.00 616.37 ? 13  DT  F P     1 
ATOM   5012 O OP1   . DT  C 3 13  ? 94.398  133.361 100.451 1.00 616.37 ? 13  DT  F OP1   1 
ATOM   5013 O OP2   . DT  C 3 13  ? 96.486  132.599 99.180  1.00 616.37 ? 13  DT  F OP2   1 
ATOM   5014 O "O5'" . DT  C 3 13  ? 94.408  131.231 99.135  1.00 616.37 ? 13  DT  F "O5'" 1 
ATOM   5015 C "C5'" . DT  C 3 13  ? 94.725  130.441 97.996  1.00 616.37 ? 13  DT  F "C5'" 1 
ATOM   5016 C "C4'" . DT  C 3 13  ? 93.462  129.919 97.335  1.00 616.37 ? 13  DT  F "C4'" 1 
ATOM   5017 O "O4'" . DT  C 3 13  ? 93.471  130.278 95.927  1.00 616.37 ? 13  DT  F "O4'" 1 
ATOM   5018 C "C3'" . DT  C 3 13  ? 93.300  128.407 97.373  1.00 616.37 ? 13  DT  F "C3'" 1 
ATOM   5019 O "O3'" . DT  C 3 13  ? 91.919  128.066 97.414  1.00 616.37 ? 13  DT  F "O3'" 1 
ATOM   5020 C "C2'" . DT  C 3 13  ? 93.944  127.977 96.063  1.00 616.37 ? 13  DT  F "C2'" 1 
ATOM   5021 C "C1'" . DT  C 3 13  ? 93.521  129.107 95.133  1.00 616.37 ? 13  DT  F "C1'" 1 
ATOM   5022 N N1    . DT  C 3 13  ? 94.473  129.342 94.010  1.00 616.37 ? 13  DT  F N1    1 
ATOM   5023 C C2    . DT  C 3 13  ? 94.123  128.954 92.739  1.00 616.37 ? 13  DT  F C2    1 
ATOM   5024 O O2    . DT  C 3 13  ? 93.057  128.429 92.471  1.00 616.37 ? 13  DT  F O2    1 
ATOM   5025 N N3    . DT  C 3 13  ? 95.064  129.220 91.781  1.00 616.37 ? 13  DT  F N3    1 
ATOM   5026 C C4    . DT  C 3 13  ? 96.299  129.814 91.965  1.00 616.37 ? 13  DT  F C4    1 
ATOM   5027 O O4    . DT  C 3 13  ? 97.080  130.006 91.038  1.00 616.37 ? 13  DT  F O4    1 
ATOM   5028 C C5    . DT  C 3 13  ? 96.606  130.191 93.324  1.00 616.37 ? 13  DT  F C5    1 
ATOM   5029 C C7    . DT  C 3 13  ? 97.918  130.843 93.649  1.00 616.37 ? 13  DT  F C7    1 
ATOM   5030 C C6    . DT  C 3 13  ? 95.689  129.939 94.270  1.00 616.37 ? 13  DT  F C6    1 
ATOM   5031 P P     . DC  C 3 14  ? 91.462  126.606 97.908  1.00 595.19 ? 14  DC  F P     1 
ATOM   5032 O OP1   . DC  C 3 14  ? 90.274  126.776 98.774  1.00 595.19 ? 14  DC  F OP1   1 
ATOM   5033 O OP2   . DC  C 3 14  ? 92.661  125.914 98.431  1.00 595.19 ? 14  DC  F OP2   1 
ATOM   5034 O "O5'" . DC  C 3 14  ? 91.019  125.868 96.561  1.00 595.19 ? 14  DC  F "O5'" 1 
ATOM   5035 C "C5'" . DC  C 3 14  ? 89.969  126.407 95.770  1.00 595.19 ? 14  DC  F "C5'" 1 
ATOM   5036 C "C4'" . DC  C 3 14  ? 89.870  125.685 94.438  1.00 595.19 ? 14  DC  F "C4'" 1 
ATOM   5037 O "O4'" . DC  C 3 14  ? 90.946  126.118 93.566  1.00 595.19 ? 14  DC  F "O4'" 1 
ATOM   5038 C "C3'" . DC  C 3 14  ? 89.967  124.160 94.519  1.00 595.19 ? 14  DC  F "C3'" 1 
ATOM   5039 O "O3'" . DC  C 3 14  ? 88.922  123.566 93.765  1.00 595.19 ? 14  DC  F "O3'" 1 
ATOM   5040 C "C2'" . DC  C 3 14  ? 91.340  123.849 93.922  1.00 595.19 ? 14  DC  F "C2'" 1 
ATOM   5041 C "C1'" . DC  C 3 14  ? 91.521  124.996 92.944  1.00 595.19 ? 14  DC  F "C1'" 1 
ATOM   5042 N N1    . DC  C 3 14  ? 92.947  125.301 92.651  1.00 595.19 ? 14  DC  F N1    1 
ATOM   5043 C C2    . DC  C 3 14  ? 93.390  125.343 91.325  1.00 595.19 ? 14  DC  F C2    1 
ATOM   5044 O O2    . DC  C 3 14  ? 92.584  125.128 90.411  1.00 595.19 ? 14  DC  F O2    1 
ATOM   5045 N N3    . DC  C 3 14  ? 94.695  125.620 91.080  1.00 595.19 ? 14  DC  F N3    1 
ATOM   5046 C C4    . DC  C 3 14  ? 95.531  125.847 92.092  1.00 595.19 ? 14  DC  F C4    1 
ATOM   5047 N N4    . DC  C 3 14  ? 96.808  126.118 91.800  1.00 595.19 ? 14  DC  F N4    1 
ATOM   5048 C C5    . DC  C 3 14  ? 95.098  125.805 93.449  1.00 595.19 ? 14  DC  F C5    1 
ATOM   5049 C C6    . DC  C 3 14  ? 93.811  125.530 93.679  1.00 595.19 ? 14  DC  F C6    1 
ATOM   5050 P P     . DC  C 3 15  ? 88.731  121.972 93.767  1.00 601.75 ? 15  DC  F P     1 
ATOM   5051 O OP1   . DC  C 3 15  ? 87.292  121.693 93.569  1.00 601.75 ? 15  DC  F OP1   1 
ATOM   5052 O OP2   . DC  C 3 15  ? 89.426  121.434 94.958  1.00 601.75 ? 15  DC  F OP2   1 
ATOM   5053 O "O5'" . DC  C 3 15  ? 89.535  121.489 92.471  1.00 601.75 ? 15  DC  F "O5'" 1 
ATOM   5054 C "C5'" . DC  C 3 15  ? 89.192  122.005 91.189  1.00 601.75 ? 15  DC  F "C5'" 1 
ATOM   5055 C "C4'" . DC  C 3 15  ? 90.059  121.385 90.109  1.00 601.75 ? 15  DC  F "C4'" 1 
ATOM   5056 O "O4'" . DC  C 3 15  ? 91.363  122.027 90.099  1.00 601.75 ? 15  DC  F "O4'" 1 
ATOM   5057 C "C3'" . DC  C 3 15  ? 90.325  119.885 90.276  1.00 601.75 ? 15  DC  F "C3'" 1 
ATOM   5058 O "O3'" . DC  C 3 15  ? 90.196  119.226 89.022  1.00 601.75 ? 15  DC  F "O3'" 1 
ATOM   5059 C "C2'" . DC  C 3 15  ? 91.763  119.844 90.784  1.00 601.75 ? 15  DC  F "C2'" 1 
ATOM   5060 C "C1'" . DC  C 3 15  ? 92.363  121.038 90.065  1.00 601.75 ? 15  DC  F "C1'" 1 
ATOM   5061 N N1    . DC  C 3 15  ? 93.588  121.571 90.722  1.00 601.75 ? 15  DC  F N1    1 
ATOM   5062 C C2    . DC  C 3 15  ? 94.700  121.905 89.942  1.00 601.75 ? 15  DC  F C2    1 
ATOM   5063 O O2    . DC  C 3 15  ? 94.643  121.760 88.714  1.00 601.75 ? 15  DC  F O2    1 
ATOM   5064 N N3    . DC  C 3 15  ? 95.811  122.384 90.556  1.00 601.75 ? 15  DC  F N3    1 
ATOM   5065 C C4    . DC  C 3 15  ? 95.830  122.526 91.882  1.00 601.75 ? 15  DC  F C4    1 
ATOM   5066 N N4    . DC  C 3 15  ? 96.946  123.003 92.443  1.00 601.75 ? 15  DC  F N4    1 
ATOM   5067 C C5    . DC  C 3 15  ? 94.708  122.187 92.692  1.00 601.75 ? 15  DC  F C5    1 
ATOM   5068 C C6    . DC  C 3 15  ? 93.620  121.715 92.076  1.00 601.75 ? 15  DC  F C6    1 
ATOM   5069 P P     . DG  C 3 16  ? 90.355  117.624 88.971  1.00 596.91 ? 16  DG  F P     1 
ATOM   5070 O OP1   . DG  C 3 16  ? 89.161  116.997 88.282  1.00 596.91 ? 16  DG  F OP1   1 
ATOM   5071 O OP2   . DG  C 3 16  ? 90.696  116.990 90.311  1.00 596.91 ? 16  DG  F OP2   1 
ATOM   5072 O "O5'" . DG  C 3 16  ? 91.629  117.387 88.005  1.00 596.91 ? 16  DG  F "O5'" 1 
ATOM   5073 C "C5'" . DG  C 3 16  ? 91.604  117.924 86.659  1.00 596.91 ? 16  DG  F "C5'" 1 
ATOM   5074 C "C4'" . DG  C 3 16  ? 92.738  117.354 85.835  1.00 596.91 ? 16  DG  F "C4'" 1 
ATOM   5075 O "O4'" . DG  C 3 16  ? 93.984  117.968 86.224  1.00 596.91 ? 16  DG  F "O4'" 1 
ATOM   5076 C "C3'" . DG  C 3 16  ? 92.975  115.852 85.954  1.00 596.91 ? 16  DG  F "C3'" 1 
ATOM   5077 O "O3'" . DG  C 3 16  ? 93.536  115.387 84.730  1.00 596.91 ? 16  DG  F "O3'" 1 
ATOM   5078 C "C2'" . DG  C 3 16  ? 93.973  115.757 87.102  1.00 596.91 ? 16  DG  F "C2'" 1 
ATOM   5079 C "C1'" . DG  C 3 16  ? 94.756  117.059 87.005  1.00 596.91 ? 16  DG  F "C1'" 1 
ATOM   5080 N N9    . DG  C 3 16  ? 94.995  117.707 88.290  1.00 596.91 ? 16  DG  F N9    1 
ATOM   5081 C C8    . DG  C 3 16  ? 94.046  118.036 89.224  1.00 596.91 ? 16  DG  F C8    1 
ATOM   5082 N N7    . DG  C 3 16  ? 94.541  118.629 90.280  1.00 596.91 ? 16  DG  F N7    1 
ATOM   5083 C C5    . DG  C 3 16  ? 95.900  118.707 90.017  1.00 596.91 ? 16  DG  F C5    1 
ATOM   5084 C C6    . DG  C 3 16  ? 96.938  119.253 90.803  1.00 596.91 ? 16  DG  F C6    1 
ATOM   5085 O O6    . DG  C 3 16  ? 96.851  119.789 91.915  1.00 596.91 ? 16  DG  F O6    1 
ATOM   5086 N N1    . DG  C 3 16  ? 98.172  119.122 90.170  1.00 596.91 ? 16  DG  F N1    1 
ATOM   5087 C C2    . DG  C 3 16  ? 98.381  118.545 88.942  1.00 596.91 ? 16  DG  F C2    1 
ATOM   5088 N N2    . DG  C 3 16  ? 99.646  118.516 88.504  1.00 596.91 ? 16  DG  F N2    1 
ATOM   5089 N N3    . DG  C 3 16  ? 97.405  118.030 88.196  1.00 596.91 ? 16  DG  F N3    1 
ATOM   5090 C C4    . DG  C 3 16  ? 96.196  118.147 88.794  1.00 596.91 ? 16  DG  F C4    1 
ATOM   5091 P P     . DT  C 3 17  ? 93.578  113.803 84.445  1.00 628.12 ? 17  DT  F P     1 
ATOM   5092 O OP1   . DT  C 3 17  ? 93.417  113.647 82.983  1.00 628.12 ? 17  DT  F OP1   1 
ATOM   5093 O OP2   . DT  C 3 17  ? 92.679  113.072 85.364  1.00 628.12 ? 17  DT  F OP2   1 
ATOM   5094 O "O5'" . DT  C 3 17  ? 95.089  113.454 84.839  1.00 628.12 ? 17  DT  F "O5'" 1 
ATOM   5095 C "C5'" . DT  C 3 17  ? 96.162  114.134 84.197  1.00 628.12 ? 17  DT  F "C5'" 1 
ATOM   5096 C "C4'" . DT  C 3 17  ? 97.493  113.744 84.813  1.00 628.12 ? 17  DT  F "C4'" 1 
ATOM   5097 O "O4'" . DT  C 3 17  ? 97.757  114.578 85.974  1.00 628.12 ? 17  DT  F "O4'" 1 
ATOM   5098 C "C3'" . DT  C 3 17  ? 97.581  112.294 85.301  1.00 628.12 ? 17  DT  F "C3'" 1 
ATOM   5099 O "O3'" . DT  C 3 17  ? 98.819  111.724 84.899  1.00 628.12 ? 17  DT  F "O3'" 1 
ATOM   5100 C "C2'" . DT  C 3 17  ? 97.496  112.432 86.820  1.00 628.12 ? 17  DT  F "C2'" 1 
ATOM   5101 C "C1'" . DT  C 3 17  ? 98.199  113.759 87.027  1.00 628.12 ? 17  DT  F "C1'" 1 
ATOM   5102 N N1    . DT  C 3 17  ? 97.875  114.420 88.316  1.00 628.12 ? 17  DT  F N1    1 
ATOM   5103 C C2    . DT  C 3 17  ? 98.852  115.135 88.960  1.00 628.12 ? 17  DT  F C2    1 
ATOM   5104 O O2    . DT  C 3 17  ? 99.981  115.267 88.522  1.00 628.12 ? 17  DT  F O2    1 
ATOM   5105 N N3    . DT  C 3 17  ? 98.458  115.706 90.135  1.00 628.12 ? 17  DT  F N3    1 
ATOM   5106 C C4    . DT  C 3 17  ? 97.211  115.631 90.728  1.00 628.12 ? 17  DT  F C4    1 
ATOM   5107 O O4    . DT  C 3 17  ? 96.960  116.183 91.796  1.00 628.12 ? 17  DT  F O4    1 
ATOM   5108 C C5    . DT  C 3 17  ? 96.231  114.861 90.006  1.00 628.12 ? 17  DT  F C5    1 
ATOM   5109 C C7    . DT  C 3 17  ? 94.843  114.709 90.550  1.00 628.12 ? 17  DT  F C7    1 
ATOM   5110 C C6    . DT  C 3 17  ? 96.606  114.297 88.847  1.00 628.12 ? 17  DT  F C6    1 
ATOM   5111 P P     . DA  C 3 18  ? 99.139  110.189 85.254  1.00 689.04 ? 18  DA  F P     1 
ATOM   5112 O OP1   . DA  C 3 18  ? 98.838  109.283 84.077  1.00 689.04 ? 18  DA  F OP1   1 
ATOM   5113 O OP2   . DA  C 3 18  ? 98.559  109.713 86.576  1.00 689.04 ? 18  DA  F OP2   1 
ATOM   5114 O "O5'" . DA  C 3 18  ? 100.741 110.239 85.431  1.00 689.04 ? 18  DA  F "O5'" 1 
ATOM   5115 C "C5'" . DA  C 3 18  ? 101.489 111.213 84.662  1.00 689.04 ? 18  DA  F "C5'" 1 
ATOM   5116 C "C4'" . DA  C 3 18  ? 102.387 112.009 85.578  1.00 689.04 ? 18  DA  F "C4'" 1 
ATOM   5117 O "O4'" . DA  C 3 18  ? 101.600 112.595 86.638  1.00 689.04 ? 18  DA  F "O4'" 1 
ATOM   5118 C "C3'" . DA  C 3 18  ? 103.491 111.203 86.258  1.00 689.04 ? 18  DA  F "C3'" 1 
ATOM   5119 O "O3'" . DA  C 3 18  ? 104.666 112.002 86.324  1.00 689.04 ? 18  DA  F "O3'" 1 
ATOM   5120 C "C2'" . DA  C 3 18  ? 102.911 110.958 87.646  1.00 689.04 ? 18  DA  F "C2'" 1 
ATOM   5121 C "C1'" . DA  C 3 18  ? 102.207 112.278 87.887  1.00 689.04 ? 18  DA  F "C1'" 1 
ATOM   5122 N N9    . DA  C 3 18  ? 101.160 112.247 88.904  1.00 689.04 ? 18  DA  F N9    1 
ATOM   5123 C C8    . DA  C 3 18  ? 99.865  111.831 88.735  1.00 689.04 ? 18  DA  F C8    1 
ATOM   5124 N N7    . DA  C 3 18  ? 99.137  111.941 89.816  1.00 689.04 ? 18  DA  F N7    1 
ATOM   5125 C C5    . DA  C 3 18  ? 100.008 112.453 90.764  1.00 689.04 ? 18  DA  F C5    1 
ATOM   5126 C C6    . DA  C 3 18  ? 99.836  112.783 92.119  1.00 689.04 ? 18  DA  F C6    1 
ATOM   5127 N N6    . DA  C 3 18  ? 98.687  112.635 92.769  1.00 689.04 ? 18  DA  F N6    1 
ATOM   5128 N N1    . DA  C 3 18  ? 100.911 113.261 92.787  1.00 689.04 ? 18  DA  F N1    1 
ATOM   5129 C C2    . DA  C 3 18  ? 102.066 113.397 92.123  1.00 689.04 ? 18  DA  F C2    1 
ATOM   5130 N N3    . DA  C 3 18  ? 102.342 113.127 90.851  1.00 689.04 ? 18  DA  F N3    1 
ATOM   5131 C C4    . DA  C 3 18  ? 101.260 112.648 90.217  1.00 689.04 ? 18  DA  F C4    1 
ATOM   5132 P P     . DG  C 3 19  ? 105.982 111.099 86.493  1.00 739.08 ? 19  DG  F P     1 
ATOM   5133 O OP1   . DG  C 3 19  ? 106.952 111.316 85.348  1.00 739.08 ? 19  DG  F OP1   1 
ATOM   5134 O OP2   . DG  C 3 19  ? 105.641 109.644 86.753  1.00 739.08 ? 19  DG  F OP2   1 
ATOM   5135 O "O5'" . DG  C 3 19  ? 106.663 111.697 87.830  1.00 739.08 ? 19  DG  F "O5'" 1 
ATOM   5136 C "C5'" . DG  C 3 19  ? 105.815 112.304 88.840  1.00 739.08 ? 19  DG  F "C5'" 1 
ATOM   5137 C "C4'" . DG  C 3 19  ? 105.873 111.470 90.097  1.00 739.08 ? 19  DG  F "C4'" 1 
ATOM   5138 O "O4'" . DG  C 3 19  ? 104.577 111.468 90.734  1.00 739.08 ? 19  DG  F "O4'" 1 
ATOM   5139 C "C3'" . DG  C 3 19  ? 106.247 110.004 89.864  1.00 739.08 ? 19  DG  F "C3'" 1 
ATOM   5140 O "O3'" . DG  C 3 19  ? 107.273 109.601 90.763  1.00 739.08 ? 19  DG  F "O3'" 1 
ATOM   5141 C "C2'" . DG  C 3 19  ? 104.949 109.258 90.155  1.00 739.08 ? 19  DG  F "C2'" 1 
ATOM   5142 C "C1'" . DG  C 3 19  ? 104.332 110.151 91.210  1.00 739.08 ? 19  DG  F "C1'" 1 
ATOM   5143 N N9    . DG  C 3 19  ? 102.897 109.953 91.382  1.00 739.08 ? 19  DG  F N9    1 
ATOM   5144 C C8    . DG  C 3 19  ? 101.998 109.513 90.444  1.00 739.08 ? 19  DG  F C8    1 
ATOM   5145 N N7    . DG  C 3 19  ? 100.776 109.418 90.907  1.00 739.08 ? 19  DG  F N7    1 
ATOM   5146 C C5    . DG  C 3 19  ? 100.884 109.808 92.235  1.00 739.08 ? 19  DG  F C5    1 
ATOM   5147 C C6    . DG  C 3 19  ? 99.889  109.901 93.236  1.00 739.08 ? 19  DG  F C6    1 
ATOM   5148 O O6    . DG  C 3 19  ? 98.681  109.649 93.135  1.00 739.08 ? 19  DG  F O6    1 
ATOM   5149 N N1    . DG  C 3 19  ? 100.424 110.340 94.447  1.00 739.08 ? 19  DG  F N1    1 
ATOM   5150 C C2    . DG  C 3 19  ? 101.744 110.646 94.666  1.00 739.08 ? 19  DG  F C2    1 
ATOM   5151 N N2    . DG  C 3 19  ? 102.068 111.045 95.903  1.00 739.08 ? 19  DG  F N2    1 
ATOM   5152 N N3    . DG  C 3 19  ? 102.686 110.557 93.729  1.00 739.08 ? 19  DG  F N3    1 
ATOM   5153 C C4    . DG  C 3 19  ? 102.186 110.135 92.543  1.00 739.08 ? 19  DG  F C4    1 
HETATM 5154 P P     . 2DA C 3 20  ? 108.113 108.400 90.108  1.00 737.88 ? 20  2DA F P     1 
HETATM 5155 O OP1   . 2DA C 3 20  ? 109.563 108.813 90.054  1.00 737.88 ? 20  2DA F OP1   1 
HETATM 5156 O OP2   . 2DA C 3 20  ? 107.424 107.935 88.847  1.00 737.88 ? 20  2DA F OP2   1 
HETATM 5157 O "O5'" . 2DA C 3 20  ? 107.952 107.254 91.230  1.00 737.88 ? 20  2DA F "O5'" 1 
HETATM 5158 C "C5'" . 2DA C 3 20  ? 106.674 106.746 91.613  1.00 737.88 ? 20  2DA F "C5'" 1 
HETATM 5159 C "C4'" . 2DA C 3 20  ? 106.424 107.133 93.065  1.00 737.88 ? 20  2DA F "C4'" 1 
HETATM 5160 O "O4'" . 2DA C 3 20  ? 105.238 107.920 93.187  1.00 737.88 ? 20  2DA F "O4'" 1 
HETATM 5161 C "C3'" . 2DA C 3 20  ? 106.227 105.907 93.945  1.00 737.88 ? 20  2DA F "C3'" 1 
HETATM 5162 C "C2'" . 2DA C 3 20  ? 105.175 106.325 94.955  1.00 737.88 ? 20  2DA F "C2'" 1 
HETATM 5163 C "C1'" . 2DA C 3 20  ? 104.599 107.629 94.427  1.00 737.88 ? 20  2DA F "C1'" 1 
HETATM 5164 N N9    . 2DA C 3 20  ? 103.150 107.440 94.233  1.00 737.88 ? 20  2DA F N9    1 
HETATM 5165 C C8    . 2DA C 3 20  ? 102.535 107.071 93.097  1.00 737.88 ? 20  2DA F C8    1 
HETATM 5166 N N7    . 2DA C 3 20  ? 101.194 106.983 93.283  1.00 737.88 ? 20  2DA F N7    1 
HETATM 5167 C C5    . 2DA C 3 20  ? 100.943 107.293 94.567  1.00 737.88 ? 20  2DA F C5    1 
HETATM 5168 C C6    . 2DA C 3 20  ? 99.745  107.402 95.429  1.00 737.88 ? 20  2DA F C6    1 
HETATM 5169 N N6    . 2DA C 3 20  ? 98.508  107.151 94.942  1.00 737.88 ? 20  2DA F N6    1 
HETATM 5170 N N1    . 2DA C 3 20  ? 99.929  107.760 96.717  1.00 737.88 ? 20  2DA F N1    1 
HETATM 5171 C C2    . 2DA C 3 20  ? 101.152 108.016 97.213  1.00 737.88 ? 20  2DA F C2    1 
HETATM 5172 N N3    . 2DA C 3 20  ? 102.280 107.942 96.490  1.00 737.88 ? 20  2DA F N3    1 
HETATM 5173 C C4    . 2DA C 3 20  ? 102.238 107.591 95.186  1.00 737.88 ? 20  2DA F C4    1 
# 
