data_9DA7
# 
_entry.id   9DA7 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9DA7         pdb_00009da7 10.2210/pdb9da7/pdb 
WWPDB D_1000287674 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-19 ? 
2 'Structure model' 1 1 2025-03-12 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
_pdbx_audit_revision_category.ordinal             1 
_pdbx_audit_revision_category.revision_ordinal    2 
_pdbx_audit_revision_category.data_content_type   'Structure model' 
_pdbx_audit_revision_category.category            citation 
# 
_pdbx_audit_revision_item.ordinal             1 
_pdbx_audit_revision_item.revision_ordinal    2 
_pdbx_audit_revision_item.data_content_type   'Structure model' 
_pdbx_audit_revision_item.item                '_citation.journal_volume' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9DA7 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-21 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              vprasad@bcm.edu 
_pdbx_contact_author.name_first         B.V.V 
_pdbx_contact_author.name_last          Prasad 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1172-2071 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zhao, B.'       1 ?                   
'Pham, S.H.'     2 0000-0001-6642-8796 
'Neetu, N.'      3 ?                   
'Sankaran, B.'   4 0000-0002-3266-8131 
'Prasad, B.V.V.' 5 0000-0002-1172-2071 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Virol. 
_citation.journal_id_ASTM           JOVIAM 
_citation.journal_id_CSD            0825 
_citation.journal_id_ISSN           1098-5514 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            99 
_citation.language                  ? 
_citation.page_first                e0175724 
_citation.page_last                 e0175724 
_citation.title                     
'Conformational flexibility is a critical factor in designing broad-spectrum human norovirus protease inhibitors.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1128/jvi.01757-24 
_citation.pdbx_database_id_PubMed   39873493 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Pham, S.'       1  ?                   
primary 'Zhao, B.'       2  ?                   
primary 'Neetu, N.'      3  ?                   
primary 'Sankaran, B.'   4  ?                   
primary 'Patil, K.'      5  ?                   
primary 'Ramani, S.'     6  0000-0001-5631-8534 
primary 'Song, Y.'       7  ?                   
primary 'Estes, M.K.'    8  0000-0002-4813-4249 
primary 'Palzkill, T.'   9  ?                   
primary 'Prasad, B.V.V.' 10 0000-0002-1172-2071 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Peptidase C37' 19304.264 1  ? ? ? ? 
2 non-polymer syn 
;4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
;
600.678   1  ? ? ? ? 
3 water       nat water 18.015    17 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;APPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQGAKEFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPEG
TVVTLLIKRSTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAA
ARGGNTVICATQGSEGEATLE
;
_entity_poly.pdbx_seq_one_letter_code_can   
;APPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQGAKEFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPEG
TVVTLLIKRSTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAA
ARGGNTVICATQGSEGEATLE
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
;
AG7 
3 water HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ALA n 
1 2   PRO n 
1 3   PRO n 
1 4   SER n 
1 5   ILE n 
1 6   TRP n 
1 7   SER n 
1 8   ARG n 
1 9   ILE n 
1 10  VAL n 
1 11  ASN n 
1 12  PHE n 
1 13  GLY n 
1 14  SER n 
1 15  GLY n 
1 16  TRP n 
1 17  GLY n 
1 18  PHE n 
1 19  TRP n 
1 20  VAL n 
1 21  SER n 
1 22  PRO n 
1 23  SER n 
1 24  LEU n 
1 25  PHE n 
1 26  ILE n 
1 27  THR n 
1 28  SER n 
1 29  THR n 
1 30  HIS n 
1 31  VAL n 
1 32  ILE n 
1 33  PRO n 
1 34  GLN n 
1 35  GLY n 
1 36  ALA n 
1 37  LYS n 
1 38  GLU n 
1 39  PHE n 
1 40  PHE n 
1 41  GLY n 
1 42  VAL n 
1 43  PRO n 
1 44  ILE n 
1 45  LYS n 
1 46  GLN n 
1 47  ILE n 
1 48  GLN n 
1 49  VAL n 
1 50  HIS n 
1 51  LYS n 
1 52  SER n 
1 53  GLY n 
1 54  GLU n 
1 55  PHE n 
1 56  CYS n 
1 57  ARG n 
1 58  LEU n 
1 59  ARG n 
1 60  PHE n 
1 61  PRO n 
1 62  LYS n 
1 63  PRO n 
1 64  ILE n 
1 65  ARG n 
1 66  THR n 
1 67  ASP n 
1 68  VAL n 
1 69  THR n 
1 70  GLY n 
1 71  MET n 
1 72  ILE n 
1 73  LEU n 
1 74  GLU n 
1 75  GLU n 
1 76  GLY n 
1 77  ALA n 
1 78  PRO n 
1 79  GLU n 
1 80  GLY n 
1 81  THR n 
1 82  VAL n 
1 83  VAL n 
1 84  THR n 
1 85  LEU n 
1 86  LEU n 
1 87  ILE n 
1 88  LYS n 
1 89  ARG n 
1 90  SER n 
1 91  THR n 
1 92  GLY n 
1 93  GLU n 
1 94  LEU n 
1 95  MET n 
1 96  PRO n 
1 97  LEU n 
1 98  ALA n 
1 99  ALA n 
1 100 ARG n 
1 101 MET n 
1 102 GLY n 
1 103 THR n 
1 104 HIS n 
1 105 ALA n 
1 106 THR n 
1 107 MET n 
1 108 LYS n 
1 109 ILE n 
1 110 GLN n 
1 111 GLY n 
1 112 ARG n 
1 113 THR n 
1 114 VAL n 
1 115 GLY n 
1 116 GLY n 
1 117 GLN n 
1 118 MET n 
1 119 GLY n 
1 120 MET n 
1 121 LEU n 
1 122 LEU n 
1 123 THR n 
1 124 GLY n 
1 125 SER n 
1 126 ASN n 
1 127 ALA n 
1 128 LYS n 
1 129 SER n 
1 130 MET n 
1 131 ASP n 
1 132 LEU n 
1 133 GLY n 
1 134 THR n 
1 135 THR n 
1 136 PRO n 
1 137 GLY n 
1 138 ASP n 
1 139 CYS n 
1 140 GLY n 
1 141 CYS n 
1 142 PRO n 
1 143 TYR n 
1 144 ILE n 
1 145 TYR n 
1 146 LYS n 
1 147 ARG n 
1 148 GLY n 
1 149 ASN n 
1 150 ASP n 
1 151 TYR n 
1 152 VAL n 
1 153 VAL n 
1 154 ILE n 
1 155 GLY n 
1 156 VAL n 
1 157 HIS n 
1 158 THR n 
1 159 ALA n 
1 160 ALA n 
1 161 ALA n 
1 162 ARG n 
1 163 GLY n 
1 164 GLY n 
1 165 ASN n 
1 166 THR n 
1 167 VAL n 
1 168 ILE n 
1 169 CYS n 
1 170 ALA n 
1 171 THR n 
1 172 GLN n 
1 173 GLY n 
1 174 SER n 
1 175 GLU n 
1 176 GLY n 
1 177 GLU n 
1 178 ALA n 
1 179 THR n 
1 180 LEU n 
1 181 GLU n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   181 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      Norovirus 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     142786 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli B' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     37762 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
AG7 non-polymer         . 
;4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
;
'RUPINTRIVIR, bound form' 'C31 H41 F N4 O7' 600.678 
ALA 'L-peptide linking' y ALANINE ?                         'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE ?                         'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                         'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                         'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE ?                         'C3 H7 N O2 S'    121.158 
GLN 'L-peptide linking' y GLUTAMINE ?                         'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                         'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE ?                         'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE ?                         'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER ?                         'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE ?                         'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE ?                         'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE ?                         'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE ?                         'C5 H11 N O2 S'   149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                         'C9 H11 N O2'     165.189 
PRO 'L-peptide linking' y PROLINE ?                         'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE ?                         'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE ?                         'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                         'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE ?                         'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE ?                         'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ALA 1   1   ?   ?   ?   A . n 
A 1 2   PRO 2   2   ?   ?   ?   A . n 
A 1 3   PRO 3   3   ?   ?   ?   A . n 
A 1 4   SER 4   4   4   SER SER A . n 
A 1 5   ILE 5   5   5   ILE ILE A . n 
A 1 6   TRP 6   6   6   TRP TRP A . n 
A 1 7   SER 7   7   7   SER SER A . n 
A 1 8   ARG 8   8   8   ARG ARG A . n 
A 1 9   ILE 9   9   9   ILE ILE A . n 
A 1 10  VAL 10  10  10  VAL VAL A . n 
A 1 11  ASN 11  11  11  ASN ASN A . n 
A 1 12  PHE 12  12  12  PHE PHE A . n 
A 1 13  GLY 13  13  13  GLY GLY A . n 
A 1 14  SER 14  14  14  SER SER A . n 
A 1 15  GLY 15  15  15  GLY GLY A . n 
A 1 16  TRP 16  16  16  TRP TRP A . n 
A 1 17  GLY 17  17  17  GLY GLY A . n 
A 1 18  PHE 18  18  18  PHE PHE A . n 
A 1 19  TRP 19  19  19  TRP TRP A . n 
A 1 20  VAL 20  20  20  VAL VAL A . n 
A 1 21  SER 21  21  21  SER SER A . n 
A 1 22  PRO 22  22  22  PRO PRO A . n 
A 1 23  SER 23  23  23  SER SER A . n 
A 1 24  LEU 24  24  24  LEU LEU A . n 
A 1 25  PHE 25  25  25  PHE PHE A . n 
A 1 26  ILE 26  26  26  ILE ILE A . n 
A 1 27  THR 27  27  27  THR THR A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  THR 29  29  29  THR THR A . n 
A 1 30  HIS 30  30  30  HIS HIS A . n 
A 1 31  VAL 31  31  31  VAL VAL A . n 
A 1 32  ILE 32  32  32  ILE ILE A . n 
A 1 33  PRO 33  33  33  PRO PRO A . n 
A 1 34  GLN 34  34  34  GLN GLN A . n 
A 1 35  GLY 35  35  35  GLY GLY A . n 
A 1 36  ALA 36  36  36  ALA ALA A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  GLU 38  38  38  GLU GLU A . n 
A 1 39  PHE 39  39  39  PHE PHE A . n 
A 1 40  PHE 40  40  40  PHE PHE A . n 
A 1 41  GLY 41  41  41  GLY GLY A . n 
A 1 42  VAL 42  42  42  VAL VAL A . n 
A 1 43  PRO 43  43  43  PRO PRO A . n 
A 1 44  ILE 44  44  44  ILE ILE A . n 
A 1 45  LYS 45  45  45  LYS LYS A . n 
A 1 46  GLN 46  46  46  GLN GLN A . n 
A 1 47  ILE 47  47  47  ILE ILE A . n 
A 1 48  GLN 48  48  48  GLN GLN A . n 
A 1 49  VAL 49  49  49  VAL VAL A . n 
A 1 50  HIS 50  50  50  HIS HIS A . n 
A 1 51  LYS 51  51  51  LYS LYS A . n 
A 1 52  SER 52  52  52  SER SER A . n 
A 1 53  GLY 53  53  53  GLY GLY A . n 
A 1 54  GLU 54  54  54  GLU GLU A . n 
A 1 55  PHE 55  55  55  PHE PHE A . n 
A 1 56  CYS 56  56  56  CYS CYS A . n 
A 1 57  ARG 57  57  57  ARG ARG A . n 
A 1 58  LEU 58  58  58  LEU LEU A . n 
A 1 59  ARG 59  59  59  ARG ARG A . n 
A 1 60  PHE 60  60  60  PHE PHE A . n 
A 1 61  PRO 61  61  61  PRO PRO A . n 
A 1 62  LYS 62  62  62  LYS LYS A . n 
A 1 63  PRO 63  63  63  PRO PRO A . n 
A 1 64  ILE 64  64  64  ILE ILE A . n 
A 1 65  ARG 65  65  65  ARG ARG A . n 
A 1 66  THR 66  66  66  THR THR A . n 
A 1 67  ASP 67  67  67  ASP ASP A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  THR 69  69  69  THR THR A . n 
A 1 70  GLY 70  70  70  GLY GLY A . n 
A 1 71  MET 71  71  71  MET MET A . n 
A 1 72  ILE 72  72  72  ILE ILE A . n 
A 1 73  LEU 73  73  73  LEU LEU A . n 
A 1 74  GLU 74  74  74  GLU GLU A . n 
A 1 75  GLU 75  75  75  GLU GLU A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  ALA 77  77  77  ALA ALA A . n 
A 1 78  PRO 78  78  78  PRO PRO A . n 
A 1 79  GLU 79  79  79  GLU GLU A . n 
A 1 80  GLY 80  80  80  GLY GLY A . n 
A 1 81  THR 81  81  81  THR THR A . n 
A 1 82  VAL 82  82  82  VAL VAL A . n 
A 1 83  VAL 83  83  83  VAL VAL A . n 
A 1 84  THR 84  84  84  THR THR A . n 
A 1 85  LEU 85  85  85  LEU LEU A . n 
A 1 86  LEU 86  86  86  LEU LEU A . n 
A 1 87  ILE 87  87  87  ILE ILE A . n 
A 1 88  LYS 88  88  88  LYS LYS A . n 
A 1 89  ARG 89  89  89  ARG ARG A . n 
A 1 90  SER 90  90  90  SER SER A . n 
A 1 91  THR 91  91  91  THR THR A . n 
A 1 92  GLY 92  92  92  GLY GLY A . n 
A 1 93  GLU 93  93  93  GLU GLU A . n 
A 1 94  LEU 94  94  94  LEU LEU A . n 
A 1 95  MET 95  95  95  MET MET A . n 
A 1 96  PRO 96  96  96  PRO PRO A . n 
A 1 97  LEU 97  97  97  LEU LEU A . n 
A 1 98  ALA 98  98  98  ALA ALA A . n 
A 1 99  ALA 99  99  99  ALA ALA A . n 
A 1 100 ARG 100 100 100 ARG ARG A . n 
A 1 101 MET 101 101 101 MET MET A . n 
A 1 102 GLY 102 102 102 GLY GLY A . n 
A 1 103 THR 103 103 103 THR THR A . n 
A 1 104 HIS 104 104 104 HIS HIS A . n 
A 1 105 ALA 105 105 105 ALA ALA A . n 
A 1 106 THR 106 106 106 THR THR A . n 
A 1 107 MET 107 107 107 MET MET A . n 
A 1 108 LYS 108 108 108 LYS LYS A . n 
A 1 109 ILE 109 109 109 ILE ILE A . n 
A 1 110 GLN 110 110 110 GLN GLN A . n 
A 1 111 GLY 111 111 111 GLY GLY A . n 
A 1 112 ARG 112 112 112 ARG ARG A . n 
A 1 113 THR 113 113 113 THR THR A . n 
A 1 114 VAL 114 114 114 VAL VAL A . n 
A 1 115 GLY 115 115 115 GLY GLY A . n 
A 1 116 GLY 116 116 116 GLY GLY A . n 
A 1 117 GLN 117 117 117 GLN GLN A . n 
A 1 118 MET 118 118 118 MET MET A . n 
A 1 119 GLY 119 119 119 GLY GLY A . n 
A 1 120 MET 120 120 120 MET MET A . n 
A 1 121 LEU 121 121 121 LEU LEU A . n 
A 1 122 LEU 122 122 122 LEU LEU A . n 
A 1 123 THR 123 123 ?   ?   ?   A . n 
A 1 124 GLY 124 124 ?   ?   ?   A . n 
A 1 125 SER 125 125 ?   ?   ?   A . n 
A 1 126 ASN 126 126 ?   ?   ?   A . n 
A 1 127 ALA 127 127 ?   ?   ?   A . n 
A 1 128 LYS 128 128 ?   ?   ?   A . n 
A 1 129 SER 129 129 ?   ?   ?   A . n 
A 1 130 MET 130 130 ?   ?   ?   A . n 
A 1 131 ASP 131 131 ?   ?   ?   A . n 
A 1 132 LEU 132 132 ?   ?   ?   A . n 
A 1 133 GLY 133 133 133 GLY GLY A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 THR 135 135 135 THR THR A . n 
A 1 136 PRO 136 136 136 PRO PRO A . n 
A 1 137 GLY 137 137 137 GLY GLY A . n 
A 1 138 ASP 138 138 138 ASP ASP A . n 
A 1 139 CYS 139 139 139 CYS CYS A . n 
A 1 140 GLY 140 140 140 GLY GLY A . n 
A 1 141 CYS 141 141 141 CYS CYS A . n 
A 1 142 PRO 142 142 142 PRO PRO A . n 
A 1 143 TYR 143 143 143 TYR TYR A . n 
A 1 144 ILE 144 144 144 ILE ILE A . n 
A 1 145 TYR 145 145 145 TYR TYR A . n 
A 1 146 LYS 146 146 146 LYS LYS A . n 
A 1 147 ARG 147 147 147 ARG ARG A . n 
A 1 148 GLY 148 148 148 GLY GLY A . n 
A 1 149 ASN 149 149 149 ASN ASN A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 TYR 151 151 151 TYR TYR A . n 
A 1 152 VAL 152 152 152 VAL VAL A . n 
A 1 153 VAL 153 153 153 VAL VAL A . n 
A 1 154 ILE 154 154 154 ILE ILE A . n 
A 1 155 GLY 155 155 155 GLY GLY A . n 
A 1 156 VAL 156 156 156 VAL VAL A . n 
A 1 157 HIS 157 157 157 HIS HIS A . n 
A 1 158 THR 158 158 158 THR THR A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 ALA 160 160 160 ALA ALA A . n 
A 1 161 ALA 161 161 161 ALA ALA A . n 
A 1 162 ARG 162 162 162 ARG ARG A . n 
A 1 163 GLY 163 163 163 GLY GLY A . n 
A 1 164 GLY 164 164 164 GLY GLY A . n 
A 1 165 ASN 165 165 165 ASN ASN A . n 
A 1 166 THR 166 166 166 THR THR A . n 
A 1 167 VAL 167 167 167 VAL VAL A . n 
A 1 168 ILE 168 168 168 ILE ILE A . n 
A 1 169 CYS 169 169 169 CYS CYS A . n 
A 1 170 ALA 170 170 170 ALA ALA A . n 
A 1 171 THR 171 171 171 THR THR A . n 
A 1 172 GLN 172 172 172 GLN GLN A . n 
A 1 173 GLY 173 173 ?   ?   ?   A . n 
A 1 174 SER 174 174 ?   ?   ?   A . n 
A 1 175 GLU 175 175 ?   ?   ?   A . n 
A 1 176 GLY 176 176 ?   ?   ?   A . n 
A 1 177 GLU 177 177 ?   ?   ?   A . n 
A 1 178 ALA 178 178 ?   ?   ?   A . n 
A 1 179 THR 179 179 ?   ?   ?   A . n 
A 1 180 LEU 180 180 ?   ?   ?   A . n 
A 1 181 GLU 181 181 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        AG7 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   AG7 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 AG7 1  201 201 AG7 AG7 A . 
C 3 HOH 1  301 111 HOH HOH A . 
C 3 HOH 2  302 71  HOH HOH A . 
C 3 HOH 3  303 126 HOH HOH A . 
C 3 HOH 4  304 19  HOH HOH A . 
C 3 HOH 5  305 161 HOH HOH A . 
C 3 HOH 6  306 8   HOH HOH A . 
C 3 HOH 7  307 5   HOH HOH A . 
C 3 HOH 8  308 166 HOH HOH A . 
C 3 HOH 9  309 4   HOH HOH A . 
C 3 HOH 10 310 123 HOH HOH A . 
C 3 HOH 11 311 17  HOH HOH A . 
C 3 HOH 12 312 1   HOH HOH A . 
C 3 HOH 13 313 128 HOH HOH A . 
C 3 HOH 14 314 150 HOH HOH A . 
C 3 HOH 15 315 139 HOH HOH A . 
C 3 HOH 16 316 74  HOH HOH A . 
C 3 HOH 17 317 6   HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.21rc1_5156 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .            2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .            3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .            4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9DA7 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     56.569 
_cell.length_a_esd                 ? 
_cell.length_b                     56.569 
_cell.length_b_esd                 ? 
_cell.length_c                     95.064 
_cell.length_c_esd                 ? 
_cell.volume                       263456.618 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9DA7 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9DA7 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.27 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          45.92 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.6 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M BIS-TRIS pH 5.5, 2.0 M Ammonium sulfate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-02-15 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97936 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 19-ID' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97936 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   19-ID 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          43.00 
_reflns.entry_id                                       9DA7 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.5 
_reflns.d_resolution_low                               48.99 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     12340 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.52 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                12.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.05 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.1133 
_reflns.pdbx_Rpim_I_all                                0.03192 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1085 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.5 
_reflns_shell.d_res_low                                     3.15 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.34 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             6035 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               12.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.972 
_reflns_shell.pdbx_CC_star                                  0.993 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.78 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               46.21 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9DA7 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.50 
_refine.ls_d_res_low                             48.99 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     6439 
_refine.ls_number_reflns_R_free                  326 
_refine.ls_number_reflns_R_work                  6113 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.54 
_refine.ls_percent_reflns_R_free                 5.06 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2536 
_refine.ls_R_factor_R_free                       0.2915 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2515 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 35.1275 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1566 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.50 
_refine_hist.d_res_low                        48.99 
_refine_hist.number_atoms_solvent             17 
_refine_hist.number_atoms_total               1261 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1201 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         43 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0072  ? 1273 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0500  ? 1722 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0596  ? 191  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0094  ? 217  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.6413 ? 452  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.50 3.15  . . 160 3009 99.78 . . . . 0.3204 . . . . . . . . . . . 0.3897 
'X-RAY DIFFRACTION' 3.15 48.99 . . 166 3104 99.30 . . . . 0.2271 . . . . . . . . . . . 0.2574 
# 
_struct.entry_id                     9DA7 
_struct.title                        'Human norovirus GII.4 Houston protease in complex with rupintrivir' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9DA7 
_struct_keywords.text            'Viral protease with inhibitor, VIRAL PROTEIN' 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q6REV3_9CALI 
_struct_ref.pdbx_db_accession          Q6REV3 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;APPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQGAKEFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPEG
TVVTLLIKRSTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAA
ARGGNTVICATQGSEGEATLE
;
_struct_ref.pdbx_align_begin           1009 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9DA7 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 181 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q6REV3 
_struct_ref_seq.db_align_beg                  1009 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  1189 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       181 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 SER A 4  ? SER A 7  ? SER A 4  SER A 7  5 ? 4 
HELX_P HELX_P2 AA2 HIS A 30 ? ILE A 32 ? HIS A 30 ILE A 32 5 ? 3 
HELX_P HELX_P3 AA3 LYS A 45 ? ILE A 47 ? LYS A 45 ILE A 47 5 ? 3 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        none 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            139 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           AG7 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           C19 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             139 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            AG7 
_struct_conn.ptnr2_auth_seq_id             201 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.767 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      AG7 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      139 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       AG7 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        201 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       139 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               C19 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        AG7 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 8 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA3 6 7 ? anti-parallel 
AA3 7 8 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE A 9   ? PHE A 12  ? ILE A 9   PHE A 12  
AA1 2 GLY A 15  ? TRP A 19  ? GLY A 15  TRP A 19  
AA1 3 LEU A 24  ? SER A 28  ? LEU A 24  SER A 28  
AA1 4 PHE A 55  ? ARG A 59  ? PHE A 55  ARG A 59  
AA1 5 GLN A 48  ? SER A 52  ? GLN A 48  SER A 52  
AA2 1 GLU A 38  ? PHE A 39  ? GLU A 38  PHE A 39  
AA2 2 VAL A 42  ? PRO A 43  ? VAL A 42  PRO A 43  
AA3 1 ILE A 72  ? LEU A 73  ? ILE A 72  LEU A 73  
AA3 2 ASP A 150 ? ALA A 160 ? ASP A 150 ALA A 160 
AA3 3 THR A 166 ? THR A 171 ? THR A 166 THR A 171 
AA3 4 ARG A 112 ? LEU A 121 ? ARG A 112 LEU A 121 
AA3 5 LEU A 94  ? ILE A 109 ? LEU A 94  ILE A 109 
AA3 6 VAL A 82  ? LYS A 88  ? VAL A 82  LYS A 88  
AA3 7 PRO A 142 ? ARG A 147 ? PRO A 142 ARG A 147 
AA3 8 ASP A 150 ? ALA A 160 ? ASP A 150 ALA A 160 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL A 10  ? N VAL A 10  O GLY A 17  ? O GLY A 17  
AA1 2 3 N PHE A 18  ? N PHE A 18  O ILE A 26  ? O ILE A 26  
AA1 3 4 N PHE A 25  ? N PHE A 25  O LEU A 58  ? O LEU A 58  
AA1 4 5 O PHE A 55  ? O PHE A 55  N SER A 52  ? N SER A 52  
AA2 1 2 N PHE A 39  ? N PHE A 39  O VAL A 42  ? O VAL A 42  
AA3 1 2 N ILE A 72  ? N ILE A 72  O VAL A 153 ? O VAL A 153 
AA3 2 3 N THR A 158 ? N THR A 158 O ILE A 168 ? O ILE A 168 
AA3 3 4 O VAL A 167 ? O VAL A 167 N GLY A 119 ? N GLY A 119 
AA3 4 5 O MET A 118 ? O MET A 118 N GLY A 102 ? N GLY A 102 
AA3 5 6 O LEU A 97  ? O LEU A 97  N LEU A 85  ? N LEU A 85  
AA3 6 7 N THR A 84  ? N THR A 84  O ILE A 144 ? O ILE A 144 
AA3 7 8 N TYR A 145 ? N TYR A 145 O VAL A 152 ? O VAL A 152 
# 
_pdbx_entry_details.entry_id                   9DA7 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    GLN 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     110 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             73.16 
_pdbx_validate_torsion.psi             38.23 
# 
_pdbx_struct_special_symmetry.id              1 
_pdbx_struct_special_symmetry.PDB_model_num   1 
_pdbx_struct_special_symmetry.auth_asym_id    A 
_pdbx_struct_special_symmetry.auth_comp_id    HOH 
_pdbx_struct_special_symmetry.auth_seq_id     313 
_pdbx_struct_special_symmetry.PDB_ins_code    ? 
_pdbx_struct_special_symmetry.label_asym_id   C 
_pdbx_struct_special_symmetry.label_comp_id   HOH 
_pdbx_struct_special_symmetry.label_seq_id    . 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ALA 1   ? A ALA 1   
2  1 Y 1 A PRO 2   ? A PRO 2   
3  1 Y 1 A PRO 3   ? A PRO 3   
4  1 Y 1 A THR 123 ? A THR 123 
5  1 Y 1 A GLY 124 ? A GLY 124 
6  1 Y 1 A SER 125 ? A SER 125 
7  1 Y 1 A ASN 126 ? A ASN 126 
8  1 Y 1 A ALA 127 ? A ALA 127 
9  1 Y 1 A LYS 128 ? A LYS 128 
10 1 Y 1 A SER 129 ? A SER 129 
11 1 Y 1 A MET 130 ? A MET 130 
12 1 Y 1 A ASP 131 ? A ASP 131 
13 1 Y 1 A LEU 132 ? A LEU 132 
14 1 Y 1 A GLY 173 ? A GLY 173 
15 1 Y 1 A SER 174 ? A SER 174 
16 1 Y 1 A GLU 175 ? A GLU 175 
17 1 Y 1 A GLY 176 ? A GLY 176 
18 1 Y 1 A GLU 177 ? A GLU 177 
19 1 Y 1 A ALA 178 ? A ALA 178 
20 1 Y 1 A THR 179 ? A THR 179 
21 1 Y 1 A LEU 180 ? A LEU 180 
22 1 Y 1 A GLU 181 ? A GLU 181 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
AG7 C01  C N N 1   
AG7 C02  C N N 2   
AG7 O03  O N N 3   
AG7 C04  C N R 4   
AG7 C05  C N N 5   
AG7 C06  C Y N 6   
AG7 C07  C Y N 7   
AG7 C08  C Y N 8   
AG7 C09  C Y N 9   
AG7 C10  C Y N 10  
AG7 C11  C Y N 11  
AG7 N12  N N N 12  
AG7 C13  C N R 13  
AG7 C14  C N N 14  
AG7 C15  C N S 15  
AG7 C16  C N N 16  
AG7 N17  N N N 17  
AG7 O18  O N N 18  
AG7 C19  C N N 19  
AG7 C20  C N N 20  
AG7 C21  C N N 21  
AG7 O22  O N N 22  
AG7 O23  O N N 23  
AG7 C47  C N N 24  
AG7 O48  O N N 25  
AG7 C50  C N N 26  
AG7 C53  C N N 27  
AG7 C57  C N S 28  
AG7 N58  N N N 29  
AG7 C59  C N N 30  
AG7 O60  O N N 31  
AG7 C78  C N N 32  
AG7 C81  C N N 33  
AG7 F1   F N N 34  
AG7 C82  C N N 35  
AG7 C83  C N N 36  
AG7 C84  C N N 37  
AG7 C1   C Y N 38  
AG7 C2   C Y N 39  
AG7 C3   C Y N 40  
AG7 O4   O Y N 41  
AG7 N5   N Y N 42  
AG7 C4   C N N 43  
AG7 H2   H N N 44  
AG7 H3   H N N 45  
AG7 H27  H N N 46  
AG7 H28  H N N 47  
AG7 H29  H N N 48  
AG7 H30  H N N 49  
AG7 H31  H N N 50  
AG7 H33  H N N 51  
AG7 H34  H N N 52  
AG7 H49  H N N 53  
AG7 H91  H N N 54  
AG7 H35  H N N 55  
AG7 H36  H N N 56  
AG7 H94  H N N 57  
AG7 H39  H N N 58  
AG7 H191 H N N 59  
AG7 H192 H N N 60  
AG7 H41  H N N 61  
AG7 H42  H N N 62  
AG7 H51  H N N 63  
AG7 H52  H N N 64  
AG7 H53  H N N 65  
AG7 H54  H N N 66  
AG7 H56  H N N 67  
AG7 H77  H N N 68  
AG7 H61  H N N 69  
AG7 H79  H N N 70  
AG7 H82  H N N 71  
AG7 H84  H N N 72  
AG7 H85  H N N 73  
AG7 H86  H N N 74  
AG7 H87  H N N 75  
AG7 H88  H N N 76  
AG7 H89  H N N 77  
AG7 H90  H N N 78  
AG7 H92  H N N 79  
AG7 H93  H N N 80  
AG7 H8   H N N 81  
AG7 H5   H N N 82  
AG7 H6   H N N 83  
AG7 H7   H N N 84  
ALA N    N N N 85  
ALA CA   C N S 86  
ALA C    C N N 87  
ALA O    O N N 88  
ALA CB   C N N 89  
ALA OXT  O N N 90  
ALA H    H N N 91  
ALA H2   H N N 92  
ALA HA   H N N 93  
ALA HB1  H N N 94  
ALA HB2  H N N 95  
ALA HB3  H N N 96  
ALA HXT  H N N 97  
ARG N    N N N 98  
ARG CA   C N S 99  
ARG C    C N N 100 
ARG O    O N N 101 
ARG CB   C N N 102 
ARG CG   C N N 103 
ARG CD   C N N 104 
ARG NE   N N N 105 
ARG CZ   C N N 106 
ARG NH1  N N N 107 
ARG NH2  N N N 108 
ARG OXT  O N N 109 
ARG H    H N N 110 
ARG H2   H N N 111 
ARG HA   H N N 112 
ARG HB2  H N N 113 
ARG HB3  H N N 114 
ARG HG2  H N N 115 
ARG HG3  H N N 116 
ARG HD2  H N N 117 
ARG HD3  H N N 118 
ARG HE   H N N 119 
ARG HH11 H N N 120 
ARG HH12 H N N 121 
ARG HH21 H N N 122 
ARG HH22 H N N 123 
ARG HXT  H N N 124 
ASN N    N N N 125 
ASN CA   C N S 126 
ASN C    C N N 127 
ASN O    O N N 128 
ASN CB   C N N 129 
ASN CG   C N N 130 
ASN OD1  O N N 131 
ASN ND2  N N N 132 
ASN OXT  O N N 133 
ASN H    H N N 134 
ASN H2   H N N 135 
ASN HA   H N N 136 
ASN HB2  H N N 137 
ASN HB3  H N N 138 
ASN HD21 H N N 139 
ASN HD22 H N N 140 
ASN HXT  H N N 141 
ASP N    N N N 142 
ASP CA   C N S 143 
ASP C    C N N 144 
ASP O    O N N 145 
ASP CB   C N N 146 
ASP CG   C N N 147 
ASP OD1  O N N 148 
ASP OD2  O N N 149 
ASP OXT  O N N 150 
ASP H    H N N 151 
ASP H2   H N N 152 
ASP HA   H N N 153 
ASP HB2  H N N 154 
ASP HB3  H N N 155 
ASP HD2  H N N 156 
ASP HXT  H N N 157 
CYS N    N N N 158 
CYS CA   C N R 159 
CYS C    C N N 160 
CYS O    O N N 161 
CYS CB   C N N 162 
CYS SG   S N N 163 
CYS OXT  O N N 164 
CYS H    H N N 165 
CYS H2   H N N 166 
CYS HA   H N N 167 
CYS HB2  H N N 168 
CYS HB3  H N N 169 
CYS HG   H N N 170 
CYS HXT  H N N 171 
GLN N    N N N 172 
GLN CA   C N S 173 
GLN C    C N N 174 
GLN O    O N N 175 
GLN CB   C N N 176 
GLN CG   C N N 177 
GLN CD   C N N 178 
GLN OE1  O N N 179 
GLN NE2  N N N 180 
GLN OXT  O N N 181 
GLN H    H N N 182 
GLN H2   H N N 183 
GLN HA   H N N 184 
GLN HB2  H N N 185 
GLN HB3  H N N 186 
GLN HG2  H N N 187 
GLN HG3  H N N 188 
GLN HE21 H N N 189 
GLN HE22 H N N 190 
GLN HXT  H N N 191 
GLU N    N N N 192 
GLU CA   C N S 193 
GLU C    C N N 194 
GLU O    O N N 195 
GLU CB   C N N 196 
GLU CG   C N N 197 
GLU CD   C N N 198 
GLU OE1  O N N 199 
GLU OE2  O N N 200 
GLU OXT  O N N 201 
GLU H    H N N 202 
GLU H2   H N N 203 
GLU HA   H N N 204 
GLU HB2  H N N 205 
GLU HB3  H N N 206 
GLU HG2  H N N 207 
GLU HG3  H N N 208 
GLU HE2  H N N 209 
GLU HXT  H N N 210 
GLY N    N N N 211 
GLY CA   C N N 212 
GLY C    C N N 213 
GLY O    O N N 214 
GLY OXT  O N N 215 
GLY H    H N N 216 
GLY H2   H N N 217 
GLY HA2  H N N 218 
GLY HA3  H N N 219 
GLY HXT  H N N 220 
HIS N    N N N 221 
HIS CA   C N S 222 
HIS C    C N N 223 
HIS O    O N N 224 
HIS CB   C N N 225 
HIS CG   C Y N 226 
HIS ND1  N Y N 227 
HIS CD2  C Y N 228 
HIS CE1  C Y N 229 
HIS NE2  N Y N 230 
HIS OXT  O N N 231 
HIS H    H N N 232 
HIS H2   H N N 233 
HIS HA   H N N 234 
HIS HB2  H N N 235 
HIS HB3  H N N 236 
HIS HD1  H N N 237 
HIS HD2  H N N 238 
HIS HE1  H N N 239 
HIS HE2  H N N 240 
HIS HXT  H N N 241 
HOH O    O N N 242 
HOH H1   H N N 243 
HOH H2   H N N 244 
ILE N    N N N 245 
ILE CA   C N S 246 
ILE C    C N N 247 
ILE O    O N N 248 
ILE CB   C N S 249 
ILE CG1  C N N 250 
ILE CG2  C N N 251 
ILE CD1  C N N 252 
ILE OXT  O N N 253 
ILE H    H N N 254 
ILE H2   H N N 255 
ILE HA   H N N 256 
ILE HB   H N N 257 
ILE HG12 H N N 258 
ILE HG13 H N N 259 
ILE HG21 H N N 260 
ILE HG22 H N N 261 
ILE HG23 H N N 262 
ILE HD11 H N N 263 
ILE HD12 H N N 264 
ILE HD13 H N N 265 
ILE HXT  H N N 266 
LEU N    N N N 267 
LEU CA   C N S 268 
LEU C    C N N 269 
LEU O    O N N 270 
LEU CB   C N N 271 
LEU CG   C N N 272 
LEU CD1  C N N 273 
LEU CD2  C N N 274 
LEU OXT  O N N 275 
LEU H    H N N 276 
LEU H2   H N N 277 
LEU HA   H N N 278 
LEU HB2  H N N 279 
LEU HB3  H N N 280 
LEU HG   H N N 281 
LEU HD11 H N N 282 
LEU HD12 H N N 283 
LEU HD13 H N N 284 
LEU HD21 H N N 285 
LEU HD22 H N N 286 
LEU HD23 H N N 287 
LEU HXT  H N N 288 
LYS N    N N N 289 
LYS CA   C N S 290 
LYS C    C N N 291 
LYS O    O N N 292 
LYS CB   C N N 293 
LYS CG   C N N 294 
LYS CD   C N N 295 
LYS CE   C N N 296 
LYS NZ   N N N 297 
LYS OXT  O N N 298 
LYS H    H N N 299 
LYS H2   H N N 300 
LYS HA   H N N 301 
LYS HB2  H N N 302 
LYS HB3  H N N 303 
LYS HG2  H N N 304 
LYS HG3  H N N 305 
LYS HD2  H N N 306 
LYS HD3  H N N 307 
LYS HE2  H N N 308 
LYS HE3  H N N 309 
LYS HZ1  H N N 310 
LYS HZ2  H N N 311 
LYS HZ3  H N N 312 
LYS HXT  H N N 313 
MET N    N N N 314 
MET CA   C N S 315 
MET C    C N N 316 
MET O    O N N 317 
MET CB   C N N 318 
MET CG   C N N 319 
MET SD   S N N 320 
MET CE   C N N 321 
MET OXT  O N N 322 
MET H    H N N 323 
MET H2   H N N 324 
MET HA   H N N 325 
MET HB2  H N N 326 
MET HB3  H N N 327 
MET HG2  H N N 328 
MET HG3  H N N 329 
MET HE1  H N N 330 
MET HE2  H N N 331 
MET HE3  H N N 332 
MET HXT  H N N 333 
PHE N    N N N 334 
PHE CA   C N S 335 
PHE C    C N N 336 
PHE O    O N N 337 
PHE CB   C N N 338 
PHE CG   C Y N 339 
PHE CD1  C Y N 340 
PHE CD2  C Y N 341 
PHE CE1  C Y N 342 
PHE CE2  C Y N 343 
PHE CZ   C Y N 344 
PHE OXT  O N N 345 
PHE H    H N N 346 
PHE H2   H N N 347 
PHE HA   H N N 348 
PHE HB2  H N N 349 
PHE HB3  H N N 350 
PHE HD1  H N N 351 
PHE HD2  H N N 352 
PHE HE1  H N N 353 
PHE HE2  H N N 354 
PHE HZ   H N N 355 
PHE HXT  H N N 356 
PRO N    N N N 357 
PRO CA   C N S 358 
PRO C    C N N 359 
PRO O    O N N 360 
PRO CB   C N N 361 
PRO CG   C N N 362 
PRO CD   C N N 363 
PRO OXT  O N N 364 
PRO H    H N N 365 
PRO HA   H N N 366 
PRO HB2  H N N 367 
PRO HB3  H N N 368 
PRO HG2  H N N 369 
PRO HG3  H N N 370 
PRO HD2  H N N 371 
PRO HD3  H N N 372 
PRO HXT  H N N 373 
SER N    N N N 374 
SER CA   C N S 375 
SER C    C N N 376 
SER O    O N N 377 
SER CB   C N N 378 
SER OG   O N N 379 
SER OXT  O N N 380 
SER H    H N N 381 
SER H2   H N N 382 
SER HA   H N N 383 
SER HB2  H N N 384 
SER HB3  H N N 385 
SER HG   H N N 386 
SER HXT  H N N 387 
THR N    N N N 388 
THR CA   C N S 389 
THR C    C N N 390 
THR O    O N N 391 
THR CB   C N R 392 
THR OG1  O N N 393 
THR CG2  C N N 394 
THR OXT  O N N 395 
THR H    H N N 396 
THR H2   H N N 397 
THR HA   H N N 398 
THR HB   H N N 399 
THR HG1  H N N 400 
THR HG21 H N N 401 
THR HG22 H N N 402 
THR HG23 H N N 403 
THR HXT  H N N 404 
TRP N    N N N 405 
TRP CA   C N S 406 
TRP C    C N N 407 
TRP O    O N N 408 
TRP CB   C N N 409 
TRP CG   C Y N 410 
TRP CD1  C Y N 411 
TRP CD2  C Y N 412 
TRP NE1  N Y N 413 
TRP CE2  C Y N 414 
TRP CE3  C Y N 415 
TRP CZ2  C Y N 416 
TRP CZ3  C Y N 417 
TRP CH2  C Y N 418 
TRP OXT  O N N 419 
TRP H    H N N 420 
TRP H2   H N N 421 
TRP HA   H N N 422 
TRP HB2  H N N 423 
TRP HB3  H N N 424 
TRP HD1  H N N 425 
TRP HE1  H N N 426 
TRP HE3  H N N 427 
TRP HZ2  H N N 428 
TRP HZ3  H N N 429 
TRP HH2  H N N 430 
TRP HXT  H N N 431 
TYR N    N N N 432 
TYR CA   C N S 433 
TYR C    C N N 434 
TYR O    O N N 435 
TYR CB   C N N 436 
TYR CG   C Y N 437 
TYR CD1  C Y N 438 
TYR CD2  C Y N 439 
TYR CE1  C Y N 440 
TYR CE2  C Y N 441 
TYR CZ   C Y N 442 
TYR OH   O N N 443 
TYR OXT  O N N 444 
TYR H    H N N 445 
TYR H2   H N N 446 
TYR HA   H N N 447 
TYR HB2  H N N 448 
TYR HB3  H N N 449 
TYR HD1  H N N 450 
TYR HD2  H N N 451 
TYR HE1  H N N 452 
TYR HE2  H N N 453 
TYR HH   H N N 454 
TYR HXT  H N N 455 
VAL N    N N N 456 
VAL CA   C N S 457 
VAL C    C N N 458 
VAL O    O N N 459 
VAL CB   C N N 460 
VAL CG1  C N N 461 
VAL CG2  C N N 462 
VAL OXT  O N N 463 
VAL H    H N N 464 
VAL H2   H N N 465 
VAL HA   H N N 466 
VAL HB   H N N 467 
VAL HG11 H N N 468 
VAL HG12 H N N 469 
VAL HG13 H N N 470 
VAL HG21 H N N 471 
VAL HG22 H N N 472 
VAL HG23 H N N 473 
VAL HXT  H N N 474 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
AG7 C01 C02  sing N N 1   
AG7 C01 O03  doub N N 2   
AG7 C01 C57  sing N N 3   
AG7 C02 C04  sing N N 4   
AG7 C02 H2   sing N N 5   
AG7 C02 H3   sing N N 6   
AG7 C04 C05  sing N N 7   
AG7 C04 C47  sing N N 8   
AG7 C04 H27  sing N N 9   
AG7 C05 C06  sing N N 10  
AG7 C05 H28  sing N N 11  
AG7 C05 H29  sing N N 12  
AG7 C06 C07  doub Y N 13  
AG7 C06 C11  sing Y N 14  
AG7 C07 C08  sing Y N 15  
AG7 C07 H30  sing N N 16  
AG7 C08 C09  doub Y N 17  
AG7 C08 H31  sing N N 18  
AG7 C09 C10  sing Y N 19  
AG7 C09 F1   sing N N 20  
AG7 C10 C11  doub Y N 21  
AG7 C10 H33  sing N N 22  
AG7 C11 H34  sing N N 23  
AG7 N12 C13  sing N N 24  
AG7 N12 C47  sing N N 25  
AG7 N12 H49  sing N N 26  
AG7 C13 C14  sing N N 27  
AG7 C13 C19  sing N N 28  
AG7 C13 H91  sing N N 29  
AG7 C14 C15  sing N N 30  
AG7 C14 H35  sing N N 31  
AG7 C14 H36  sing N N 32  
AG7 C15 C16  sing N N 33  
AG7 C15 C84  sing N N 34  
AG7 C15 H94  sing N N 35  
AG7 C16 N17  sing N N 36  
AG7 C16 O18  doub N N 37  
AG7 N17 C83  sing N N 38  
AG7 N17 H39  sing N N 39  
AG7 C19 C20  sing N N 40  
AG7 C19 H191 sing N N 41  
AG7 C19 H192 sing N N 42  
AG7 C20 C21  sing N N 43  
AG7 C20 H41  sing N N 44  
AG7 C20 H42  sing N N 45  
AG7 C21 O22  sing N N 46  
AG7 C21 O23  doub N N 47  
AG7 O22 C50  sing N N 48  
AG7 C47 O48  doub N N 49  
AG7 C50 C53  sing N N 50  
AG7 C50 H51  sing N N 51  
AG7 C50 H52  sing N N 52  
AG7 C53 H53  sing N N 53  
AG7 C53 H54  sing N N 54  
AG7 C53 H56  sing N N 55  
AG7 C57 N58  sing N N 56  
AG7 C57 C78  sing N N 57  
AG7 C57 H77  sing N N 58  
AG7 N58 C59  sing N N 59  
AG7 N58 H61  sing N N 60  
AG7 C59 O60  doub N N 61  
AG7 C59 C1   sing N N 62  
AG7 C78 C81  sing N N 63  
AG7 C78 C82  sing N N 64  
AG7 C78 H79  sing N N 65  
AG7 C81 H82  sing N N 66  
AG7 C81 H84  sing N N 67  
AG7 C81 H85  sing N N 68  
AG7 C82 H86  sing N N 69  
AG7 C82 H87  sing N N 70  
AG7 C82 H88  sing N N 71  
AG7 C83 C84  sing N N 72  
AG7 C83 H89  sing N N 73  
AG7 C83 H90  sing N N 74  
AG7 C84 H92  sing N N 75  
AG7 C84 H93  sing N N 76  
AG7 C1  C2   sing Y N 77  
AG7 C1  N5   doub Y N 78  
AG7 C2  C3   doub Y N 79  
AG7 C2  H8   sing N N 80  
AG7 C3  O4   sing Y N 81  
AG7 C3  C4   sing N N 82  
AG7 O4  N5   sing Y N 83  
AG7 C4  H5   sing N N 84  
AG7 C4  H6   sing N N 85  
AG7 C4  H7   sing N N 86  
ALA N   CA   sing N N 87  
ALA N   H    sing N N 88  
ALA N   H2   sing N N 89  
ALA CA  C    sing N N 90  
ALA CA  CB   sing N N 91  
ALA CA  HA   sing N N 92  
ALA C   O    doub N N 93  
ALA C   OXT  sing N N 94  
ALA CB  HB1  sing N N 95  
ALA CB  HB2  sing N N 96  
ALA CB  HB3  sing N N 97  
ALA OXT HXT  sing N N 98  
ARG N   CA   sing N N 99  
ARG N   H    sing N N 100 
ARG N   H2   sing N N 101 
ARG CA  C    sing N N 102 
ARG CA  CB   sing N N 103 
ARG CA  HA   sing N N 104 
ARG C   O    doub N N 105 
ARG C   OXT  sing N N 106 
ARG CB  CG   sing N N 107 
ARG CB  HB2  sing N N 108 
ARG CB  HB3  sing N N 109 
ARG CG  CD   sing N N 110 
ARG CG  HG2  sing N N 111 
ARG CG  HG3  sing N N 112 
ARG CD  NE   sing N N 113 
ARG CD  HD2  sing N N 114 
ARG CD  HD3  sing N N 115 
ARG NE  CZ   sing N N 116 
ARG NE  HE   sing N N 117 
ARG CZ  NH1  sing N N 118 
ARG CZ  NH2  doub N N 119 
ARG NH1 HH11 sing N N 120 
ARG NH1 HH12 sing N N 121 
ARG NH2 HH21 sing N N 122 
ARG NH2 HH22 sing N N 123 
ARG OXT HXT  sing N N 124 
ASN N   CA   sing N N 125 
ASN N   H    sing N N 126 
ASN N   H2   sing N N 127 
ASN CA  C    sing N N 128 
ASN CA  CB   sing N N 129 
ASN CA  HA   sing N N 130 
ASN C   O    doub N N 131 
ASN C   OXT  sing N N 132 
ASN CB  CG   sing N N 133 
ASN CB  HB2  sing N N 134 
ASN CB  HB3  sing N N 135 
ASN CG  OD1  doub N N 136 
ASN CG  ND2  sing N N 137 
ASN ND2 HD21 sing N N 138 
ASN ND2 HD22 sing N N 139 
ASN OXT HXT  sing N N 140 
ASP N   CA   sing N N 141 
ASP N   H    sing N N 142 
ASP N   H2   sing N N 143 
ASP CA  C    sing N N 144 
ASP CA  CB   sing N N 145 
ASP CA  HA   sing N N 146 
ASP C   O    doub N N 147 
ASP C   OXT  sing N N 148 
ASP CB  CG   sing N N 149 
ASP CB  HB2  sing N N 150 
ASP CB  HB3  sing N N 151 
ASP CG  OD1  doub N N 152 
ASP CG  OD2  sing N N 153 
ASP OD2 HD2  sing N N 154 
ASP OXT HXT  sing N N 155 
CYS N   CA   sing N N 156 
CYS N   H    sing N N 157 
CYS N   H2   sing N N 158 
CYS CA  C    sing N N 159 
CYS CA  CB   sing N N 160 
CYS CA  HA   sing N N 161 
CYS C   O    doub N N 162 
CYS C   OXT  sing N N 163 
CYS CB  SG   sing N N 164 
CYS CB  HB2  sing N N 165 
CYS CB  HB3  sing N N 166 
CYS SG  HG   sing N N 167 
CYS OXT HXT  sing N N 168 
GLN N   CA   sing N N 169 
GLN N   H    sing N N 170 
GLN N   H2   sing N N 171 
GLN CA  C    sing N N 172 
GLN CA  CB   sing N N 173 
GLN CA  HA   sing N N 174 
GLN C   O    doub N N 175 
GLN C   OXT  sing N N 176 
GLN CB  CG   sing N N 177 
GLN CB  HB2  sing N N 178 
GLN CB  HB3  sing N N 179 
GLN CG  CD   sing N N 180 
GLN CG  HG2  sing N N 181 
GLN CG  HG3  sing N N 182 
GLN CD  OE1  doub N N 183 
GLN CD  NE2  sing N N 184 
GLN NE2 HE21 sing N N 185 
GLN NE2 HE22 sing N N 186 
GLN OXT HXT  sing N N 187 
GLU N   CA   sing N N 188 
GLU N   H    sing N N 189 
GLU N   H2   sing N N 190 
GLU CA  C    sing N N 191 
GLU CA  CB   sing N N 192 
GLU CA  HA   sing N N 193 
GLU C   O    doub N N 194 
GLU C   OXT  sing N N 195 
GLU CB  CG   sing N N 196 
GLU CB  HB2  sing N N 197 
GLU CB  HB3  sing N N 198 
GLU CG  CD   sing N N 199 
GLU CG  HG2  sing N N 200 
GLU CG  HG3  sing N N 201 
GLU CD  OE1  doub N N 202 
GLU CD  OE2  sing N N 203 
GLU OE2 HE2  sing N N 204 
GLU OXT HXT  sing N N 205 
GLY N   CA   sing N N 206 
GLY N   H    sing N N 207 
GLY N   H2   sing N N 208 
GLY CA  C    sing N N 209 
GLY CA  HA2  sing N N 210 
GLY CA  HA3  sing N N 211 
GLY C   O    doub N N 212 
GLY C   OXT  sing N N 213 
GLY OXT HXT  sing N N 214 
HIS N   CA   sing N N 215 
HIS N   H    sing N N 216 
HIS N   H2   sing N N 217 
HIS CA  C    sing N N 218 
HIS CA  CB   sing N N 219 
HIS CA  HA   sing N N 220 
HIS C   O    doub N N 221 
HIS C   OXT  sing N N 222 
HIS CB  CG   sing N N 223 
HIS CB  HB2  sing N N 224 
HIS CB  HB3  sing N N 225 
HIS CG  ND1  sing Y N 226 
HIS CG  CD2  doub Y N 227 
HIS ND1 CE1  doub Y N 228 
HIS ND1 HD1  sing N N 229 
HIS CD2 NE2  sing Y N 230 
HIS CD2 HD2  sing N N 231 
HIS CE1 NE2  sing Y N 232 
HIS CE1 HE1  sing N N 233 
HIS NE2 HE2  sing N N 234 
HIS OXT HXT  sing N N 235 
HOH O   H1   sing N N 236 
HOH O   H2   sing N N 237 
ILE N   CA   sing N N 238 
ILE N   H    sing N N 239 
ILE N   H2   sing N N 240 
ILE CA  C    sing N N 241 
ILE CA  CB   sing N N 242 
ILE CA  HA   sing N N 243 
ILE C   O    doub N N 244 
ILE C   OXT  sing N N 245 
ILE CB  CG1  sing N N 246 
ILE CB  CG2  sing N N 247 
ILE CB  HB   sing N N 248 
ILE CG1 CD1  sing N N 249 
ILE CG1 HG12 sing N N 250 
ILE CG1 HG13 sing N N 251 
ILE CG2 HG21 sing N N 252 
ILE CG2 HG22 sing N N 253 
ILE CG2 HG23 sing N N 254 
ILE CD1 HD11 sing N N 255 
ILE CD1 HD12 sing N N 256 
ILE CD1 HD13 sing N N 257 
ILE OXT HXT  sing N N 258 
LEU N   CA   sing N N 259 
LEU N   H    sing N N 260 
LEU N   H2   sing N N 261 
LEU CA  C    sing N N 262 
LEU CA  CB   sing N N 263 
LEU CA  HA   sing N N 264 
LEU C   O    doub N N 265 
LEU C   OXT  sing N N 266 
LEU CB  CG   sing N N 267 
LEU CB  HB2  sing N N 268 
LEU CB  HB3  sing N N 269 
LEU CG  CD1  sing N N 270 
LEU CG  CD2  sing N N 271 
LEU CG  HG   sing N N 272 
LEU CD1 HD11 sing N N 273 
LEU CD1 HD12 sing N N 274 
LEU CD1 HD13 sing N N 275 
LEU CD2 HD21 sing N N 276 
LEU CD2 HD22 sing N N 277 
LEU CD2 HD23 sing N N 278 
LEU OXT HXT  sing N N 279 
LYS N   CA   sing N N 280 
LYS N   H    sing N N 281 
LYS N   H2   sing N N 282 
LYS CA  C    sing N N 283 
LYS CA  CB   sing N N 284 
LYS CA  HA   sing N N 285 
LYS C   O    doub N N 286 
LYS C   OXT  sing N N 287 
LYS CB  CG   sing N N 288 
LYS CB  HB2  sing N N 289 
LYS CB  HB3  sing N N 290 
LYS CG  CD   sing N N 291 
LYS CG  HG2  sing N N 292 
LYS CG  HG3  sing N N 293 
LYS CD  CE   sing N N 294 
LYS CD  HD2  sing N N 295 
LYS CD  HD3  sing N N 296 
LYS CE  NZ   sing N N 297 
LYS CE  HE2  sing N N 298 
LYS CE  HE3  sing N N 299 
LYS NZ  HZ1  sing N N 300 
LYS NZ  HZ2  sing N N 301 
LYS NZ  HZ3  sing N N 302 
LYS OXT HXT  sing N N 303 
MET N   CA   sing N N 304 
MET N   H    sing N N 305 
MET N   H2   sing N N 306 
MET CA  C    sing N N 307 
MET CA  CB   sing N N 308 
MET CA  HA   sing N N 309 
MET C   O    doub N N 310 
MET C   OXT  sing N N 311 
MET CB  CG   sing N N 312 
MET CB  HB2  sing N N 313 
MET CB  HB3  sing N N 314 
MET CG  SD   sing N N 315 
MET CG  HG2  sing N N 316 
MET CG  HG3  sing N N 317 
MET SD  CE   sing N N 318 
MET CE  HE1  sing N N 319 
MET CE  HE2  sing N N 320 
MET CE  HE3  sing N N 321 
MET OXT HXT  sing N N 322 
PHE N   CA   sing N N 323 
PHE N   H    sing N N 324 
PHE N   H2   sing N N 325 
PHE CA  C    sing N N 326 
PHE CA  CB   sing N N 327 
PHE CA  HA   sing N N 328 
PHE C   O    doub N N 329 
PHE C   OXT  sing N N 330 
PHE CB  CG   sing N N 331 
PHE CB  HB2  sing N N 332 
PHE CB  HB3  sing N N 333 
PHE CG  CD1  doub Y N 334 
PHE CG  CD2  sing Y N 335 
PHE CD1 CE1  sing Y N 336 
PHE CD1 HD1  sing N N 337 
PHE CD2 CE2  doub Y N 338 
PHE CD2 HD2  sing N N 339 
PHE CE1 CZ   doub Y N 340 
PHE CE1 HE1  sing N N 341 
PHE CE2 CZ   sing Y N 342 
PHE CE2 HE2  sing N N 343 
PHE CZ  HZ   sing N N 344 
PHE OXT HXT  sing N N 345 
PRO N   CA   sing N N 346 
PRO N   CD   sing N N 347 
PRO N   H    sing N N 348 
PRO CA  C    sing N N 349 
PRO CA  CB   sing N N 350 
PRO CA  HA   sing N N 351 
PRO C   O    doub N N 352 
PRO C   OXT  sing N N 353 
PRO CB  CG   sing N N 354 
PRO CB  HB2  sing N N 355 
PRO CB  HB3  sing N N 356 
PRO CG  CD   sing N N 357 
PRO CG  HG2  sing N N 358 
PRO CG  HG3  sing N N 359 
PRO CD  HD2  sing N N 360 
PRO CD  HD3  sing N N 361 
PRO OXT HXT  sing N N 362 
SER N   CA   sing N N 363 
SER N   H    sing N N 364 
SER N   H2   sing N N 365 
SER CA  C    sing N N 366 
SER CA  CB   sing N N 367 
SER CA  HA   sing N N 368 
SER C   O    doub N N 369 
SER C   OXT  sing N N 370 
SER CB  OG   sing N N 371 
SER CB  HB2  sing N N 372 
SER CB  HB3  sing N N 373 
SER OG  HG   sing N N 374 
SER OXT HXT  sing N N 375 
THR N   CA   sing N N 376 
THR N   H    sing N N 377 
THR N   H2   sing N N 378 
THR CA  C    sing N N 379 
THR CA  CB   sing N N 380 
THR CA  HA   sing N N 381 
THR C   O    doub N N 382 
THR C   OXT  sing N N 383 
THR CB  OG1  sing N N 384 
THR CB  CG2  sing N N 385 
THR CB  HB   sing N N 386 
THR OG1 HG1  sing N N 387 
THR CG2 HG21 sing N N 388 
THR CG2 HG22 sing N N 389 
THR CG2 HG23 sing N N 390 
THR OXT HXT  sing N N 391 
TRP N   CA   sing N N 392 
TRP N   H    sing N N 393 
TRP N   H2   sing N N 394 
TRP CA  C    sing N N 395 
TRP CA  CB   sing N N 396 
TRP CA  HA   sing N N 397 
TRP C   O    doub N N 398 
TRP C   OXT  sing N N 399 
TRP CB  CG   sing N N 400 
TRP CB  HB2  sing N N 401 
TRP CB  HB3  sing N N 402 
TRP CG  CD1  doub Y N 403 
TRP CG  CD2  sing Y N 404 
TRP CD1 NE1  sing Y N 405 
TRP CD1 HD1  sing N N 406 
TRP CD2 CE2  doub Y N 407 
TRP CD2 CE3  sing Y N 408 
TRP NE1 CE2  sing Y N 409 
TRP NE1 HE1  sing N N 410 
TRP CE2 CZ2  sing Y N 411 
TRP CE3 CZ3  doub Y N 412 
TRP CE3 HE3  sing N N 413 
TRP CZ2 CH2  doub Y N 414 
TRP CZ2 HZ2  sing N N 415 
TRP CZ3 CH2  sing Y N 416 
TRP CZ3 HZ3  sing N N 417 
TRP CH2 HH2  sing N N 418 
TRP OXT HXT  sing N N 419 
TYR N   CA   sing N N 420 
TYR N   H    sing N N 421 
TYR N   H2   sing N N 422 
TYR CA  C    sing N N 423 
TYR CA  CB   sing N N 424 
TYR CA  HA   sing N N 425 
TYR C   O    doub N N 426 
TYR C   OXT  sing N N 427 
TYR CB  CG   sing N N 428 
TYR CB  HB2  sing N N 429 
TYR CB  HB3  sing N N 430 
TYR CG  CD1  doub Y N 431 
TYR CG  CD2  sing Y N 432 
TYR CD1 CE1  sing Y N 433 
TYR CD1 HD1  sing N N 434 
TYR CD2 CE2  doub Y N 435 
TYR CD2 HD2  sing N N 436 
TYR CE1 CZ   doub Y N 437 
TYR CE1 HE1  sing N N 438 
TYR CE2 CZ   sing Y N 439 
TYR CE2 HE2  sing N N 440 
TYR CZ  OH   sing N N 441 
TYR OH  HH   sing N N 442 
TYR OXT HXT  sing N N 443 
VAL N   CA   sing N N 444 
VAL N   H    sing N N 445 
VAL N   H2   sing N N 446 
VAL CA  C    sing N N 447 
VAL CA  CB   sing N N 448 
VAL CA  HA   sing N N 449 
VAL C   O    doub N N 450 
VAL C   OXT  sing N N 451 
VAL CB  CG1  sing N N 452 
VAL CB  CG2  sing N N 453 
VAL CB  HB   sing N N 454 
VAL CG1 HG11 sing N N 455 
VAL CG1 HG12 sing N N 456 
VAL CG1 HG13 sing N N 457 
VAL CG2 HG21 sing N N 458 
VAL CG2 HG22 sing N N 459 
VAL CG2 HG23 sing N N 460 
VAL OXT HXT  sing N N 461 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 'United States' 'P01 AI057788' 1 
'Robert A. Welch Foundation'                                                                      'United States' Q-1279         2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   6NIR 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9DA7 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017678 
_atom_sites.fract_transf_matrix[1][2]   0.010206 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.020412 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.010519 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 8.95735 ?       ? ? 7.27484  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . SER A 1 4   ? -10.36100 -26.67800 -3.19400  1.000 79.79000  ? 4   SER A N    1 
ATOM   2    C CA   . SER A 1 4   ? -9.44800  -25.76900 -2.50900  1.000 77.49000  ? 4   SER A CA   1 
ATOM   3    C C    . SER A 1 4   ? -8.54400  -25.04300 -3.49500  1.000 75.24000  ? 4   SER A C    1 
ATOM   4    O O    . SER A 1 4   ? -7.59800  -24.36300 -3.09700  1.000 74.55000  ? 4   SER A O    1 
ATOM   5    C CB   . SER A 1 4   ? -8.59200  -26.52800 -1.49500  1.000 79.02000  ? 4   SER A CB   1 
ATOM   6    O OG   . SER A 1 4   ? -9.39400  -27.12700 -0.49500  1.000 83.25000  ? 4   SER A OG   1 
ATOM   7    H HA   . SER A 1 4   ? -9.96500  -25.10400 -2.02800  1.000 81.30000  ? 4   SER A HA   1 
ATOM   8    H HB2  . SER A 1 4   ? -8.09600  -27.22100 -1.95800  1.000 83.54000  ? 4   SER A HB2  1 
ATOM   9    H HB3  . SER A 1 4   ? -7.97700  -25.90700 -1.07500  1.000 83.54000  ? 4   SER A HB3  1 
ATOM   10   H HG   . SER A 1 4   ? -9.93200  -27.66900 -0.84500  1.000 101.57000 ? 4   SER A HG   1 
ATOM   11   N N    . ILE A 1 5   ? -8.82900  -25.20200 -4.78800  1.000 38.52000  ? 5   ILE A N    1 
ATOM   12   C CA   . ILE A 1 5   ? -8.08800  -24.45400 -5.79700  1.000 37.56000  ? 5   ILE A CA   1 
ATOM   13   C C    . ILE A 1 5   ? -8.19600  -22.96100 -5.52200  1.000 35.73000  ? 5   ILE A C    1 
ATOM   14   O O    . ILE A 1 5   ? -7.24100  -22.20300 -5.72900  1.000 34.94000  ? 5   ILE A O    1 
ATOM   15   C CB   . ILE A 1 5   ? -8.59700  -24.80200 -7.20800  1.000 37.90000  ? 5   ILE A CB   1 
ATOM   16   C CG1  . ILE A 1 5   ? -8.08400  -26.17500 -7.64500  1.000 39.76000  ? 5   ILE A CG1  1 
ATOM   17   C CG2  . ILE A 1 5   ? -8.17700  -23.72500 -8.19800  1.000 36.69000  ? 5   ILE A CG2  1 
ATOM   18   C CD1  . ILE A 1 5   ? -8.75600  -27.33200 -6.93800  1.000 42.02000  ? 5   ILE A CD1  1 
ATOM   19   H H    . ILE A 1 5   ? -9.43600  -25.72200 -5.10200  1.000 56.09000  ? 5   ILE A H    1 
ATOM   20   H HA   . ILE A 1 5   ? -7.15100  -24.70000 -5.74700  1.000 53.94000  ? 5   ILE A HA   1 
ATOM   21   H HB   . ILE A 1 5   ? -9.56600  -24.83200 -7.18400  1.000 57.71000  ? 5   ILE A HB   1 
ATOM   22   H HG12 . ILE A 1 5   ? -8.24100  -26.28000 -8.59600  1.000 60.53000  ? 5   ILE A HG12 1 
ATOM   23   H HG13 . ILE A 1 5   ? -7.13300  -26.22700 -7.46200  1.000 60.53000  ? 5   ILE A HG13 1 
ATOM   24   H HG21 . ILE A 1 5   ? -8.27200  -24.07200 -9.09900  1.000 56.21000  ? 5   ILE A HG21 1 
ATOM   25   H HG22 . ILE A 1 5   ? -8.74600  -22.94900 -8.08500  1.000 56.21000  ? 5   ILE A HG22 1 
ATOM   26   H HG23 . ILE A 1 5   ? -7.25100  -23.48700 -8.03400  1.000 56.21000  ? 5   ILE A HG23 1 
ATOM   27   H HD11 . ILE A 1 5   ? -8.57400  -28.14800 -7.43000  1.000 73.62000  ? 5   ILE A HD11 1 
ATOM   28   H HD12 . ILE A 1 5   ? -8.40200  -27.40300 -6.03800  1.000 73.62000  ? 5   ILE A HD12 1 
ATOM   29   H HD13 . ILE A 1 5   ? -9.71200  -27.17100 -6.90800  1.000 73.62000  ? 5   ILE A HD13 1 
ATOM   30   N N    . TRP A 1 6   ? -9.36500  -22.51500 -5.05600  1.000 42.68000  ? 6   TRP A N    1 
ATOM   31   C CA   . TRP A 1 6   ? -9.56000  -21.09600 -4.78900  1.000 41.75000  ? 6   TRP A CA   1 
ATOM   32   C C    . TRP A 1 6   ? -8.62100  -20.59300 -3.70100  1.000 41.91000  ? 6   TRP A C    1 
ATOM   33   O O    . TRP A 1 6   ? -8.28900  -19.40300 -3.67000  1.000 41.21000  ? 6   TRP A O    1 
ATOM   34   C CB   . TRP A 1 6   ? -11.01000 -20.82900 -4.38700  1.000 42.81000  ? 6   TRP A CB   1 
ATOM   35   C CG   . TRP A 1 6   ? -11.97700 -20.82000 -5.53100  1.000 42.99000  ? 6   TRP A CG   1 
ATOM   36   C CD1  . TRP A 1 6   ? -12.87300 -21.79700 -5.85700  1.000 44.24000  ? 6   TRP A CD1  1 
ATOM   37   C CD2  . TRP A 1 6   ? -12.15000 -19.77800 -6.50000  1.000 42.13000  ? 6   TRP A CD2  1 
ATOM   38   N NE1  . TRP A 1 6   ? -13.59200 -21.42800 -6.96900  1.000 43.79000  ? 6   TRP A NE1  1 
ATOM   39   C CE2  . TRP A 1 6   ? -13.16600 -20.19300 -7.38300  1.000 42.68000  ? 6   TRP A CE2  1 
ATOM   40   C CE3  . TRP A 1 6   ? -11.54200 -18.53500 -6.70600  1.000 41.46000  ? 6   TRP A CE3  1 
ATOM   41   C CZ2  . TRP A 1 6   ? -13.58800 -19.41000 -8.45500  1.000 42.02000  ? 6   TRP A CZ2  1 
ATOM   42   C CZ3  . TRP A 1 6   ? -11.96300 -17.76000 -7.77000  1.000 41.26000  ? 6   TRP A CZ3  1 
ATOM   43   C CH2  . TRP A 1 6   ? -12.97600 -18.20000 -8.63100  1.000 41.94000  ? 6   TRP A CH2  1 
ATOM   44   H H    . TRP A 1 6   ? -10.04900 -23.00800 -4.88900  1.000 47.35000  ? 6   TRP A H    1 
ATOM   45   H HA   . TRP A 1 6   ? -9.37700  -20.59500 -5.59900  1.000 46.91000  ? 6   TRP A HA   1 
ATOM   46   H HB2  . TRP A 1 6   ? -11.29300 -21.52000 -3.76800  1.000 49.78000  ? 6   TRP A HB2  1 
ATOM   47   H HB3  . TRP A 1 6   ? -11.05800 -19.96200 -3.95400  1.000 49.78000  ? 6   TRP A HB3  1 
ATOM   48   H HD1  . TRP A 1 6   ? -12.98200 -22.59600 -5.39300  1.000 53.29000  ? 6   TRP A HD1  1 
ATOM   49   H HE1  . TRP A 1 6   ? -14.20800 -21.89700 -7.34500  1.000 51.87000  ? 6   TRP A HE1  1 
ATOM   50   H HE3  . TRP A 1 6   ? -10.86900 -18.23600 -6.13800  1.000 54.14000  ? 6   TRP A HE3  1 
ATOM   51   H HZ2  . TRP A 1 6   ? -14.26000 -19.69900 -9.02900  1.000 47.72000  ? 6   TRP A HZ2  1 
ATOM   52   H HZ3  . TRP A 1 6   ? -11.56600 -16.93200 -7.91700  1.000 49.13000  ? 6   TRP A HZ3  1 
ATOM   53   H HH2  . TRP A 1 6   ? -13.23800 -17.65700 -9.33900  1.000 50.28000  ? 6   TRP A HH2  1 
ATOM   54   N N    . SER A 1 7   ? -8.19000  -21.47400 -2.79600  1.000 44.93000  ? 7   SER A N    1 
ATOM   55   C CA   . SER A 1 7   ? -7.29600  -21.04700 -1.72600  1.000 45.15000  ? 7   SER A CA   1 
ATOM   56   C C    . SER A 1 7   ? -5.90700  -20.70600 -2.24500  1.000 45.61000  ? 7   SER A C    1 
ATOM   57   O O    . SER A 1 7   ? -5.15400  -20.01100 -1.55300  1.000 45.39000  ? 7   SER A O    1 
ATOM   58   C CB   . SER A 1 7   ? -7.19300  -22.13200 -0.65300  1.000 46.44000  ? 7   SER A CB   1 
ATOM   59   O OG   . SER A 1 7   ? -6.51600  -23.27500 -1.14300  1.000 48.28000  ? 7   SER A OG   1 
ATOM   60   H H    . SER A 1 7   ? -8.39700  -22.30800 -2.78000  1.000 52.54000  ? 7   SER A H    1 
ATOM   61   H HA   . SER A 1 7   ? -7.66200  -20.25100 -1.31000  1.000 48.62000  ? 7   SER A HA   1 
ATOM   62   H HB2  . SER A 1 7   ? -6.70400  -21.77800 0.10600   1.000 47.96000  ? 7   SER A HB2  1 
ATOM   63   H HB3  . SER A 1 7   ? -8.08700  -22.38900 -0.37900  1.000 47.96000  ? 7   SER A HB3  1 
ATOM   64   H HG   . SER A 1 7   ? -6.92900  -23.59200 -1.80100  1.000 57.54000  ? 7   SER A HG   1 
ATOM   65   N N    . ARG A 1 8   ? -5.55100  -21.18000 -3.44100  1.000 37.32000  ? 8   ARG A N    1 
ATOM   66   C CA   . ARG A 1 8   ? -4.25400  -20.85900 -4.01900  1.000 36.59000  ? 8   ARG A CA   1 
ATOM   67   C C    . ARG A 1 8   ? -4.22900  -19.46900 -4.64800  1.000 35.58000  ? 8   ARG A C    1 
ATOM   68   O O    . ARG A 1 8   ? -3.14300  -18.95200 -4.93500  1.000 35.93000  ? 8   ARG A O    1 
ATOM   69   C CB   . ARG A 1 8   ? -3.87300  -21.90100 -5.07300  1.000 37.08000  ? 8   ARG A CB   1 
ATOM   70   C CG   . ARG A 1 8   ? -3.81100  -23.36900 -4.61600  1.000 39.24000  ? 8   ARG A CG   1 
ATOM   71   C CD   . ARG A 1 8   ? -4.05100  -24.23500 -5.86300  1.000 39.74000  ? 8   ARG A CD   1 
ATOM   72   N NE   . ARG A 1 8   ? -3.87600  -25.67600 -5.71100  1.000 41.29000  ? 8   ARG A NE   1 
ATOM   73   C CZ   . ARG A 1 8   ? -2.83500  -26.35600 -6.17600  1.000 42.80000  ? 8   ARG A CZ   1 
ATOM   74   N NH1  . ARG A 1 8   ? -1.79900  -25.74600 -6.72900  1.000 43.02000  ? 8   ARG A NH1  1 
ATOM   75   N NH2  . ARG A 1 8   ? -2.83600  -27.68400 -6.09100  1.000 44.51000  ? 8   ARG A NH2  1 
ATOM   76   H H    . ARG A 1 8   ? -6.04200  -21.68700 -3.93300  1.000 53.37000  ? 8   ARG A H    1 
ATOM   77   H HA   . ARG A 1 8   ? -3.58300  -20.88200 -3.31900  1.000 42.17000  ? 8   ARG A HA   1 
ATOM   78   H HB2  . ARG A 1 8   ? -4.52300  -21.85300 -5.79100  1.000 42.60000  ? 8   ARG A HB2  1 
ATOM   79   H HB3  . ARG A 1 8   ? -2.99700  -21.67200 -5.42000  1.000 42.60000  ? 8   ARG A HB3  1 
ATOM   80   H HG2  . ARG A 1 8   ? -2.93400  -23.57000 -4.25400  1.000 46.59000  ? 8   ARG A HG2  1 
ATOM   81   H HG3  . ARG A 1 8   ? -4.50800  -23.54800 -3.96600  1.000 46.59000  ? 8   ARG A HG3  1 
ATOM   82   H HD2  . ARG A 1 8   ? -4.96900  -24.09700 -6.14300  1.000 49.79000  ? 8   ARG A HD2  1 
ATOM   83   H HD3  . ARG A 1 8   ? -3.46200  -23.92600 -6.56700  1.000 49.79000  ? 8   ARG A HD3  1 
ATOM   84   H HE   . ARG A 1 8   ? -4.48700  -26.11300 -5.29300  1.000 43.47000  ? 8   ARG A HE   1 
ATOM   85   H HH11 . ARG A 1 8   ? -1.13700  -26.21100 -7.02000  1.000 42.94000  ? 8   ARG A HH11 1 
ATOM   86   H HH12 . ARG A 1 8   ? -1.78000  -24.89000 -6.79700  1.000 42.94000  ? 8   ARG A HH12 1 
ATOM   87   H HH21 . ARG A 1 8   ? -3.50300  -28.09100 -5.73200  1.000 41.09000  ? 8   ARG A HH21 1 
ATOM   88   H HH22 . ARG A 1 8   ? -2.16400  -28.13400 -6.38300  1.000 41.09000  ? 8   ARG A HH22 1 
ATOM   89   N N    . ILE A 1 9   ? -5.39100  -18.86100 -4.87100  1.000 37.40000  ? 9   ILE A N    1 
ATOM   90   C CA   . ILE A 1 9   ? -5.46800  -17.50400 -5.40200  1.000 36.73000  ? 9   ILE A CA   1 
ATOM   91   C C    . ILE A 1 9   ? -5.36300  -16.52500 -4.24000  1.000 36.87000  ? 9   ILE A C    1 
ATOM   92   O O    . ILE A 1 9   ? -6.22200  -16.50600 -3.35300  1.000 36.88000  ? 9   ILE A O    1 
ATOM   93   C CB   . ILE A 1 9   ? -6.77000  -17.28800 -6.18500  1.000 36.57000  ? 9   ILE A CB   1 
ATOM   94   C CG1  . ILE A 1 9   ? -6.72600  -18.05800 -7.50500  1.000 35.76000  ? 9   ILE A CG1  1 
ATOM   95   C CG2  . ILE A 1 9   ? -6.99800  -15.80000 -6.42200  1.000 37.37000  ? 9   ILE A CG2  1 
ATOM   96   C CD1  . ILE A 1 9   ? -7.90400  -18.98500 -7.71300  1.000 35.92000  ? 9   ILE A CD1  1 
ATOM   97   H H    . ILE A 1 9   ? -6.15900  -19.21800 -4.72200  1.000 46.28000  ? 9   ILE A H    1 
ATOM   98   H HA   . ILE A 1 9   ? -4.72100  -17.34900 -6.00100  1.000 42.99000  ? 9   ILE A HA   1 
ATOM   99   H HB   . ILE A 1 9   ? -7.50600  -17.63100 -5.65500  1.000 48.20000  ? 9   ILE A HB   1 
ATOM   100  H HG12 . ILE A 1 9   ? -6.71400  -17.42400 -8.23900  1.000 41.06000  ? 9   ILE A HG12 1 
ATOM   101  H HG13 . ILE A 1 9   ? -5.92000  -18.59700 -7.52500  1.000 41.06000  ? 9   ILE A HG13 1 
ATOM   102  H HG21 . ILE A 1 9   ? -7.64800  -15.69100 -7.13300  1.000 54.96000  ? 9   ILE A HG21 1 
ATOM   103  H HG22 . ILE A 1 9   ? -7.33300  -15.39400 -5.60800  1.000 54.96000  ? 9   ILE A HG22 1 
ATOM   104  H HG23 . ILE A 1 9   ? -6.15800  -15.38900 -6.67900  1.000 54.96000  ? 9   ILE A HG23 1 
ATOM   105  H HD11 . ILE A 1 9   ? -7.84600  -19.37500 -8.59900  1.000 43.20000  ? 9   ILE A HD11 1 
ATOM   106  H HD12 . ILE A 1 9   ? -7.87600  -19.68400 -7.04200  1.000 43.20000  ? 9   ILE A HD12 1 
ATOM   107  H HD13 . ILE A 1 9   ? -8.72500  -18.47600 -7.62900  1.000 43.20000  ? 9   ILE A HD13 1 
ATOM   108  N N    . VAL A 1 10  ? -4.23900  -15.80500 -4.14200  1.000 38.15000  ? 10  VAL A N    1 
ATOM   109  C CA   . VAL A 1 10  ? -3.97600  -14.89400 -2.98400  1.000 39.73000  ? 10  VAL A CA   1 
ATOM   110  C C    . VAL A 1 10  ? -3.75100  -13.47200 -3.52000  1.000 40.13000  ? 10  VAL A C    1 
ATOM   111  O O    . VAL A 1 10  ? -3.13900  -13.34900 -4.58800  1.000 40.13000  ? 10  VAL A O    1 
ATOM   112  C CB   . VAL A 1 10  ? -2.76500  -15.39500 -2.17200  1.000 40.66000  ? 10  VAL A CB   1 
ATOM   113  C CG1  . VAL A 1 10  ? -2.83300  -16.89800 -1.92700  1.000 41.10000  ? 10  VAL A CG1  1 
ATOM   114  C CG2  . VAL A 1 10  ? -1.43600  -15.03500 -2.82800  1.000 41.90000  ? 10  VAL A CG2  1 
ATOM   115  H H    . VAL A 1 10  ? -3.60700  -15.81700 -4.72500  1.000 36.66000  ? 10  VAL A H    1 
ATOM   116  H HA   . VAL A 1 10  ? -4.74900  -14.87900 -2.39900  1.000 46.43000  ? 10  VAL A HA   1 
ATOM   117  H HB   . VAL A 1 10  ? -2.78300  -14.96200 -1.30400  1.000 43.14000  ? 10  VAL A HB   1 
ATOM   118  H HG11 . VAL A 1 10  ? -2.04000  -17.16200 -1.44200  1.000 47.70000  ? 10  VAL A HG11 1 
ATOM   119  H HG12 . VAL A 1 10  ? -3.62600  -17.10000 -1.40600  1.000 47.70000  ? 10  VAL A HG12 1 
ATOM   120  H HG13 . VAL A 1 10  ? -2.86500  -17.36300 -2.77700  1.000 47.70000  ? 10  VAL A HG13 1 
ATOM   121  H HG21 . VAL A 1 10  ? -1.55100  -15.02000 -3.79100  1.000 45.25000  ? 10  VAL A HG21 1 
ATOM   122  H HG22 . VAL A 1 10  ? -1.15400  -14.16200 -2.51400  1.000 45.25000  ? 10  VAL A HG22 1 
ATOM   123  H HG23 . VAL A 1 10  ? -0.77400  -15.70300 -2.59000  1.000 45.25000  ? 10  VAL A HG23 1 
ATOM   124  N N    . ASN A 1 11  ? -4.18700  -12.43400 -2.80200  1.000 58.40000  ? 11  ASN A N    1 
ATOM   125  C CA   . ASN A 1 11  ? -3.91700  -11.05800 -3.28900  1.000 58.93000  ? 11  ASN A CA   1 
ATOM   126  C C    . ASN A 1 11  ? -2.40400  -10.85500 -3.34400  1.000 59.85000  ? 11  ASN A C    1 
ATOM   127  O O    . ASN A 1 11  ? -1.73800  -11.17600 -2.33500  1.000 60.95000  ? 11  ASN A O    1 
ATOM   128  C CB   . ASN A 1 11  ? -4.55100  -9.99500  -2.40100  1.000 59.37000  ? 11  ASN A CB   1 
ATOM   129  C CG   . ASN A 1 11  ? -5.93600  -9.60100  -2.85400  1.000 59.62000  ? 11  ASN A CG   1 
ATOM   130  O OD1  . ASN A 1 11  ? -6.90300  -9.77600  -2.10600  1.000 60.89000  ? 11  ASN A OD1  1 
ATOM   131  N ND2  . ASN A 1 11  ? -6.05200  -9.05300  -4.05500  1.000 60.26000  ? 11  ASN A ND2  1 
ATOM   132  H H    . ASN A 1 11  ? -4.62200  -12.48400 -2.06200  1.000 44.68000  ? 11  ASN A H    1 
ATOM   133  H HA   . ASN A 1 11  ? -4.27100  -10.95900 -4.18600  1.000 43.22000  ? 11  ASN A HA   1 
ATOM   134  H HB2  . ASN A 1 11  ? -4.61800  -10.33900 -1.49600  1.000 48.26000  ? 11  ASN A HB2  1 
ATOM   135  H HB3  . ASN A 1 11  ? -3.99500  -9.20100  -2.41300  1.000 48.26000  ? 11  ASN A HB3  1 
ATOM   136  H HD21 . ASN A 1 11  ? -5.35500  -8.94300  -4.54600  1.000 62.59000  ? 11  ASN A HD21 1 
ATOM   137  H HD22 . ASN A 1 11  ? -6.82500  -8.81300  -4.34500  1.000 62.59000  ? 11  ASN A HD22 1 
ATOM   138  N N    . PHE A 1 12  ? -1.88100  -10.35700 -4.46600  1.000 31.03000  ? 12  PHE A N    1 
ATOM   139  C CA   . PHE A 1 12  ? -0.43900  -10.01900 -4.58900  1.000 32.28000  ? 12  PHE A CA   1 
ATOM   140  C C    . PHE A 1 12  ? -0.36800  -8.61100  -5.15600  1.000 32.79000  ? 12  PHE A C    1 
ATOM   141  O O    . PHE A 1 12  ? -0.76000  -8.44000  -6.32300  1.000 34.03000  ? 12  PHE A O    1 
ATOM   142  C CB   . PHE A 1 12  ? 0.20600   -11.10100 -5.46200  1.000 33.02000  ? 12  PHE A CB   1 
ATOM   143  C CG   . PHE A 1 12  ? 1.71900   -11.22700 -5.34800  1.000 33.95000  ? 12  PHE A CG   1 
ATOM   144  C CD1  . PHE A 1 12  ? 2.30900   -11.71700 -4.18900  1.000 34.63000  ? 12  PHE A CD1  1 
ATOM   145  C CD2  . PHE A 1 12  ? 2.54500   -10.87600 -6.40900  1.000 34.94000  ? 12  PHE A CD2  1 
ATOM   146  C CE1  . PHE A 1 12  ? 3.68600   -11.84000 -4.09300  1.000 36.01000  ? 12  PHE A CE1  1 
ATOM   147  C CE2  . PHE A 1 12  ? 3.92100   -11.00100 -6.30600  1.000 36.58000  ? 12  PHE A CE2  1 
ATOM   148  C CZ   . PHE A 1 12  ? 4.48800   -11.48300 -5.15000  1.000 37.13000  ? 12  PHE A CZ   1 
ATOM   149  H H    . PHE A 1 12  ? -2.33400  -10.19800 -5.17900  1.000 37.00000  ? 12  PHE A H    1 
ATOM   150  H HA   . PHE A 1 12  ? -0.02000  -10.02800 -3.71400  1.000 35.54000  ? 12  PHE A HA   1 
ATOM   151  H HB2  . PHE A 1 12  ? -0.17600  -11.95900 -5.21800  1.000 39.70000  ? 12  PHE A HB2  1 
ATOM   152  H HB3  . PHE A 1 12  ? -0.00000  -10.90800 -6.39000  1.000 39.70000  ? 12  PHE A HB3  1 
ATOM   153  H HD1  . PHE A 1 12  ? 1.77400   -11.96100 -3.46900  1.000 36.40000  ? 12  PHE A HD1  1 
ATOM   154  H HD2  . PHE A 1 12  ? 2.17000   -10.54900 -7.19500  1.000 36.94000  ? 12  PHE A HD2  1 
ATOM   155  H HE1  . PHE A 1 12  ? 4.06900   -12.16500 -3.31000  1.000 38.05000  ? 12  PHE A HE1  1 
ATOM   156  H HE2  . PHE A 1 12  ? 4.46300   -10.75900 -7.02200  1.000 44.89000  ? 12  PHE A HE2  1 
ATOM   157  H HZ   . PHE A 1 12  ? 5.41200   -11.56500 -5.08300  1.000 45.52000  ? 12  PHE A HZ   1 
ATOM   158  N N    . GLY A 1 13  ? 0.16700   -7.65200  -4.39900  1.000 34.95000  ? 13  GLY A N    1 
ATOM   159  C CA   . GLY A 1 13  ? 0.28600   -6.25800  -4.86500  1.000 35.35000  ? 13  GLY A CA   1 
ATOM   160  C C    . GLY A 1 13  ? -1.05900  -5.68400  -5.28300  1.000 35.33000  ? 13  GLY A C    1 
ATOM   161  O O    . GLY A 1 13  ? -2.01100  -5.80400  -4.48300  1.000 34.42000  ? 13  GLY A O    1 
ATOM   162  H H    . GLY A 1 13  ? 0.47200   -7.77900  -3.60500  1.000 40.89000  ? 13  GLY A H    1 
ATOM   163  H HA2  . GLY A 1 13  ? 0.64600   -5.70800  -4.15100  1.000 39.61000  ? 13  GLY A HA2  1 
ATOM   164  H HA3  . GLY A 1 13  ? 0.89300   -6.22000  -5.61800  1.000 39.61000  ? 13  GLY A HA3  1 
ATOM   165  N N    . SER A 1 14  ? -1.15600  -5.08800  -6.48000  1.000 40.46000  ? 14  SER A N    1 
ATOM   166  C CA   . SER A 1 14  ? -2.39900  -4.43300  -6.97800  1.000 39.79000  ? 14  SER A CA   1 
ATOM   167  C C    . SER A 1 14  ? -3.37000  -5.45400  -7.59000  1.000 39.23000  ? 14  SER A C    1 
ATOM   168  O O    . SER A 1 14  ? -4.48500  -5.02800  -7.96600  1.000 39.51000  ? 14  SER A O    1 
ATOM   169  C CB   . SER A 1 14  ? -2.05800  -3.35800  -7.97800  1.000 40.69000  ? 14  SER A CB   1 
ATOM   170  O OG   . SER A 1 14  ? -2.09700  -3.86400  -9.30500  1.000 43.00000  ? 14  SER A OG   1 
ATOM   171  H H    . SER A 1 14  ? -0.50500  -5.04500  -7.04000  1.000 47.82000  ? 14  SER A H    1 
ATOM   172  H HA   . SER A 1 14  ? -2.84900  -4.00900  -6.23000  1.000 40.49000  ? 14  SER A HA   1 
ATOM   173  H HB2  . SER A 1 14  ? -2.70100  -2.63700  -7.89700  1.000 39.31000  ? 14  SER A HB2  1 
ATOM   174  H HB3  . SER A 1 14  ? -1.16500  -3.02700  -7.79300  1.000 39.31000  ? 14  SER A HB3  1 
ATOM   175  H HG   . SER A 1 14  ? -1.53700  -4.48400  -9.39300  1.000 63.42000  ? 14  SER A HG   1 
ATOM   176  N N    . GLY A 1 15  ? -2.98900  -6.73200  -7.69400  1.000 31.25000  ? 15  GLY A N    1 
ATOM   177  C CA   . GLY A 1 15  ? -3.82500  -7.79000  -8.22100  1.000 30.41000  ? 15  GLY A CA   1 
ATOM   178  C C    . GLY A 1 15  ? -3.75600  -9.06700  -7.41200  1.000 29.26000  ? 15  GLY A C    1 
ATOM   179  O O    . GLY A 1 15  ? -3.91200  -9.04000  -6.18800  1.000 29.31000  ? 15  GLY A O    1 
ATOM   180  H H    . GLY A 1 15  ? -2.21300  -7.01300  -7.45200  1.000 41.10000  ? 15  GLY A H    1 
ATOM   181  H HA2  . GLY A 1 15  ? -4.74800  -7.49100  -8.23900  1.000 38.50000  ? 15  GLY A HA2  1 
ATOM   182  H HA3  . GLY A 1 15  ? -3.55200  -7.99100  -9.13000  1.000 38.50000  ? 15  GLY A HA3  1 
ATOM   183  N N    . TRP A 1 16  ? -3.51900  -10.19300 -8.08300  1.000 33.84000  ? 16  TRP A N    1 
ATOM   184  C CA   . TRP A 1 16  ? -3.53600  -11.49800 -7.43800  1.000 32.93000  ? 16  TRP A CA   1 
ATOM   185  C C    . TRP A 1 16  ? -2.37700  -12.34300 -7.96200  1.000 33.10000  ? 16  TRP A C    1 
ATOM   186  O O    . TRP A 1 16  ? -1.61600  -11.92400 -8.84000  1.000 34.27000  ? 16  TRP A O    1 
ATOM   187  C CB   . TRP A 1 16  ? -4.87800  -12.21000 -7.67100  1.000 31.62000  ? 16  TRP A CB   1 
ATOM   188  C CG   . TRP A 1 16  ? -6.07300  -11.39700 -7.26900  1.000 31.45000  ? 16  TRP A CG   1 
ATOM   189  C CD1  . TRP A 1 16  ? -6.66100  -10.39800 -7.98700  1.000 32.06000  ? 16  TRP A CD1  1 
ATOM   190  C CD2  . TRP A 1 16  ? -6.82500  -11.51600 -6.05500  1.000 30.98000  ? 16  TRP A CD2  1 
ATOM   191  N NE1  . TRP A 1 16  ? -7.73000  -9.88300  -7.29400  1.000 32.13000  ? 16  TRP A NE1  1 
ATOM   192  C CE2  . TRP A 1 16  ? -7.85100  -10.55300 -6.10400  1.000 31.11000  ? 16  TRP A CE2  1 
ATOM   193  C CE3  . TRP A 1 16  ? -6.72800  -12.34100 -4.93100  1.000 30.66000  ? 16  TRP A CE3  1 
ATOM   194  C CZ2  . TRP A 1 16  ? -8.77500  -10.39200 -5.07300  1.000 31.00000  ? 16  TRP A CZ2  1 
ATOM   195  C CZ3  . TRP A 1 16  ? -7.64600  -12.18000 -3.90800  1.000 30.25000  ? 16  TRP A CZ3  1 
ATOM   196  C CH2  . TRP A 1 16  ? -8.65600  -11.21400 -3.98700  1.000 30.46000  ? 16  TRP A CH2  1 
ATOM   197  H H    . TRP A 1 16  ? -3.34400  -10.22500 -8.92400  1.000 40.66000  ? 16  TRP A H    1 
ATOM   198  H HA   . TRP A 1 16  ? -3.41800  -11.38600 -6.48200  1.000 42.93000  ? 16  TRP A HA   1 
ATOM   199  H HB2  . TRP A 1 16  ? -4.96300  -12.41500 -8.61500  1.000 42.28000  ? 16  TRP A HB2  1 
ATOM   200  H HB3  . TRP A 1 16  ? -4.89000  -13.03100 -7.15400  1.000 42.28000  ? 16  TRP A HB3  1 
ATOM   201  H HD1  . TRP A 1 16  ? -6.37700  -10.10400 -8.82200  1.000 39.35000  ? 16  TRP A HD1  1 
ATOM   202  H HE1  . TRP A 1 16  ? -8.24000  -9.24500  -7.56300  1.000 43.99000  ? 16  TRP A HE1  1 
ATOM   203  H HE3  . TRP A 1 16  ? -6.05800  -12.98400 -4.87100  1.000 48.69000  ? 16  TRP A HE3  1 
ATOM   204  H HZ2  . TRP A 1 16  ? -9.44800  -9.75300  -5.12300  1.000 46.58000  ? 16  TRP A HZ2  1 
ATOM   205  H HZ3  . TRP A 1 16  ? -7.59100  -12.72300 -3.15500  1.000 47.33000  ? 16  TRP A HZ3  1 
ATOM   206  H HH2  . TRP A 1 16  ? -9.26000  -11.12900 -3.28500  1.000 44.93000  ? 16  TRP A HH2  1 
ATOM   207  N N    . GLY A 1 17  ? -2.25300  -13.54700 -7.40200  1.000 34.31000  ? 17  GLY A N    1 
ATOM   208  C CA   . GLY A 1 17  ? -1.24800  -14.51900 -7.79800  1.000 34.11000  ? 17  GLY A CA   1 
ATOM   209  C C    . GLY A 1 17  ? -1.73100  -15.90500 -7.43100  1.000 32.84000  ? 17  GLY A C    1 
ATOM   210  O O    . GLY A 1 17  ? -2.64400  -16.07000 -6.61800  1.000 32.69000  ? 17  GLY A O    1 
ATOM   211  H H    . GLY A 1 17  ? -2.76100  -13.82800 -6.76800  1.000 38.73000  ? 17  GLY A H    1 
ATOM   212  H HA2  . GLY A 1 17  ? -1.11200  -14.47900 -8.75800  1.000 33.84000  ? 17  GLY A HA2  1 
ATOM   213  H HA3  . GLY A 1 17  ? -0.40900  -14.33100 -7.35600  1.000 33.84000  ? 17  GLY A HA3  1 
ATOM   214  N N    . PHE A 1 18  ? -1.10100  -16.91200 -8.03500  1.000 30.87000  ? 18  PHE A N    1 
ATOM   215  C CA   . PHE A 1 18  ? -1.57500  -18.29000 -7.94600  1.000 30.00000  ? 18  PHE A CA   1 
ATOM   216  C C    . PHE A 1 18  ? -0.41900  -19.22500 -7.61700  1.000 30.74000  ? 18  PHE A C    1 
ATOM   217  O O    . PHE A 1 18  ? 0.65900   -19.12100 -8.21100  1.000 31.54000  ? 18  PHE A O    1 
ATOM   218  C CB   . PHE A 1 18  ? -2.25800  -18.70300 -9.26200  1.000 28.97000  ? 18  PHE A CB   1 
ATOM   219  C CG   . PHE A 1 18  ? -2.72600  -20.13100 -9.29000  1.000 29.18000  ? 18  PHE A CG   1 
ATOM   220  C CD1  . PHE A 1 18  ? -3.85100  -20.52300 -8.58300  1.000 29.39000  ? 18  PHE A CD1  1 
ATOM   221  C CD2  . PHE A 1 18  ? -2.04600  -21.08000 -10.03600 1.000 29.45000  ? 18  PHE A CD2  1 
ATOM   222  C CE1  . PHE A 1 18  ? -4.28200  -21.83800 -8.60900  1.000 29.74000  ? 18  PHE A CE1  1 
ATOM   223  C CE2  . PHE A 1 18  ? -2.47200  -22.39600 -10.06700 1.000 30.33000  ? 18  PHE A CE2  1 
ATOM   224  C CZ   . PHE A 1 18  ? -3.59200  -22.77500 -9.35200  1.000 31.16000  ? 18  PHE A CZ   1 
ATOM   225  H H    . PHE A 1 18  ? -0.38800  -16.82000 -8.50800  1.000 37.01000  ? 18  PHE A H    1 
ATOM   226  H HA   . PHE A 1 18  ? -2.22900  -18.35900 -7.23300  1.000 36.67000  ? 18  PHE A HA   1 
ATOM   227  H HB2  . PHE A 1 18  ? -3.03200  -18.13600 -9.40200  1.000 35.19000  ? 18  PHE A HB2  1 
ATOM   228  H HB3  . PHE A 1 18  ? -1.62800  -18.58400 -9.99000  1.000 35.19000  ? 18  PHE A HB3  1 
ATOM   229  H HD1  . PHE A 1 18  ? -4.31800  -19.89700 -8.07900  1.000 40.15000  ? 18  PHE A HD1  1 
ATOM   230  H HD2  . PHE A 1 18  ? -1.29000  -20.83100 -10.51700 1.000 39.83000  ? 18  PHE A HD2  1 
ATOM   231  H HE1  . PHE A 1 18  ? -5.03700  -22.09000 -8.12800  1.000 34.76000  ? 18  PHE A HE1  1 
ATOM   232  H HE2  . PHE A 1 18  ? -2.00500  -23.02500 -10.56900 1.000 37.19000  ? 18  PHE A HE2  1 
ATOM   233  H HZ   . PHE A 1 18  ? -3.88100  -23.65900 -9.37300  1.000 41.53000  ? 18  PHE A HZ   1 
ATOM   234  N N    . TRP A 1 19  ? -0.64700  -20.12600 -6.66100  1.000 22.63000  ? 19  TRP A N    1 
ATOM   235  C CA   . TRP A 1 19  ? 0.33400   -21.13900 -6.28100  1.000 24.28000  ? 19  TRP A CA   1 
ATOM   236  C C    . TRP A 1 19  ? 0.17700   -22.33500 -7.21200  1.000 24.82000  ? 19  TRP A C    1 
ATOM   237  O O    . TRP A 1 19  ? -0.83200  -23.04700 -7.15300  1.000 25.13000  ? 19  TRP A O    1 
ATOM   238  C CB   . TRP A 1 19  ? 0.15200   -21.56700 -4.82500  1.000 26.41000  ? 19  TRP A CB   1 
ATOM   239  C CG   . TRP A 1 19  ? 0.62100   -20.55800 -3.82200  1.000 26.73000  ? 19  TRP A CG   1 
ATOM   240  C CD1  . TRP A 1 19  ? -0.15600  -19.71200 -3.08600  1.000 26.23000  ? 19  TRP A CD1  1 
ATOM   241  C CD2  . TRP A 1 19  ? 1.97700   -20.28800 -3.44400  1.000 28.37000  ? 19  TRP A CD2  1 
ATOM   242  N NE1  . TRP A 1 19  ? 0.63200   -18.93200 -2.27400  1.000 27.37000  ? 19  TRP A NE1  1 
ATOM   243  C CE2  . TRP A 1 19  ? 1.94500   -19.26500 -2.47600  1.000 28.74000  ? 19  TRP A CE2  1 
ATOM   244  C CE3  . TRP A 1 19  ? 3.21500   -20.81200 -3.83100  1.000 28.65000  ? 19  TRP A CE3  1 
ATOM   245  C CZ2  . TRP A 1 19  ? 3.10200   -18.75400 -1.89200  1.000 30.59000  ? 19  TRP A CZ2  1 
ATOM   246  C CZ3  . TRP A 1 19  ? 4.36200   -20.30200 -3.24900  1.000 29.45000  ? 19  TRP A CZ3  1 
ATOM   247  C CH2  . TRP A 1 19  ? 4.29700   -19.28400 -2.29100  1.000 30.69000  ? 19  TRP A CH2  1 
ATOM   248  H H    . TRP A 1 19  ? -1.37800  -20.17000 -6.21000  1.000 32.87000  ? 19  TRP A H    1 
ATOM   249  H HA   . TRP A 1 19  ? 1.22900   -20.78000 -6.38700  1.000 34.55000  ? 19  TRP A HA   1 
ATOM   250  H HB2  . TRP A 1 19  ? -0.79100  -21.72700 -4.66300  1.000 40.52000  ? 19  TRP A HB2  1 
ATOM   251  H HB3  . TRP A 1 19  ? 0.65200   -22.38500 -4.67700  1.000 40.52000  ? 19  TRP A HB3  1 
ATOM   252  H HD1  . TRP A 1 19  ? -1.08400  -19.66900 -3.12800  1.000 36.41000  ? 19  TRP A HD1  1 
ATOM   253  H HE1  . TRP A 1 19  ? 0.34700   -18.33000 -1.72900  1.000 34.06000  ? 19  TRP A HE1  1 
ATOM   254  H HE3  . TRP A 1 19  ? 3.26600   -21.48600 -4.47000  1.000 36.45000  ? 19  TRP A HE3  1 
ATOM   255  H HZ2  . TRP A 1 19  ? 3.06300   -18.08000 -1.25300  1.000 32.95000  ? 19  TRP A HZ2  1 
ATOM   256  H HZ3  . TRP A 1 19  ? 5.19100   -20.64200 -3.49900  1.000 33.23000  ? 19  TRP A HZ3  1 
ATOM   257  H HH2  . TRP A 1 19  ? 5.08500   -18.96300 -1.91500  1.000 35.69000  ? 19  TRP A HH2  1 
ATOM   258  N N    . VAL A 1 20  ? 1.17100   -22.56200 -8.07100  1.000 28.18000  ? 20  VAL A N    1 
ATOM   259  C CA   . VAL A 1 20  ? 1.12400   -23.72100 -8.95800  1.000 28.83000  ? 20  VAL A CA   1 
ATOM   260  C C    . VAL A 1 20  ? 1.54800   -24.98300 -8.21600  1.000 31.16000  ? 20  VAL A C    1 
ATOM   261  O O    . VAL A 1 20  ? 0.98900   -26.06300 -8.43600  1.000 33.27000  ? 20  VAL A O    1 
ATOM   262  C CB   . VAL A 1 20  ? 1.99900   -23.48100 -10.20200 1.000 27.22000  ? 20  VAL A CB   1 
ATOM   263  C CG1  . VAL A 1 20  ? 2.06200   -24.74400 -11.05000 1.000 28.82000  ? 20  VAL A CG1  1 
ATOM   264  C CG2  . VAL A 1 20  ? 1.46600   -22.30800 -11.01300 1.000 25.35000  ? 20  VAL A CG2  1 
ATOM   265  H H    . VAL A 1 20  ? 1.87100   -22.07000 -8.15800  1.000 41.80000  ? 20  VAL A H    1 
ATOM   266  H HA   . VAL A 1 20  ? 0.21100   -23.84800 -9.25900  1.000 41.15000  ? 20  VAL A HA   1 
ATOM   267  H HB   . VAL A 1 20  ? 2.90100   -23.26500 -9.91800  1.000 36.02000  ? 20  VAL A HB   1 
ATOM   268  H HG11 . VAL A 1 20  ? 2.38100   -24.51100 -11.93600 1.000 40.70000  ? 20  VAL A HG11 1 
ATOM   269  H HG12 . VAL A 1 20  ? 2.67000   -25.37600 -10.63600 1.000 40.70000  ? 20  VAL A HG12 1 
ATOM   270  H HG13 . VAL A 1 20  ? 1.17300   -25.12800 -11.11100 1.000 40.70000  ? 20  VAL A HG13 1 
ATOM   271  H HG21 . VAL A 1 20  ? 2.01900   -22.19200 -11.80100 1.000 37.98000  ? 20  VAL A HG21 1 
ATOM   272  H HG22 . VAL A 1 20  ? 0.55100   -22.49600 -11.27500 1.000 37.98000  ? 20  VAL A HG22 1 
ATOM   273  H HG23 . VAL A 1 20  ? 1.49600   -21.50700 -10.46700 1.000 37.98000  ? 20  VAL A HG23 1 
ATOM   274  N N    . SER A 1 21  ? 2.54700   -24.87000 -7.34200  1.000 38.94000  ? 21  SER A N    1 
ATOM   275  C CA   . SER A 1 21  ? 3.03000   -25.97200 -6.51900  1.000 41.33000  ? 21  SER A CA   1 
ATOM   276  C C    . SER A 1 21  ? 3.32800   -25.41300 -5.13300  1.000 42.05000  ? 21  SER A C    1 
ATOM   277  O O    . SER A 1 21  ? 3.10900   -24.21800 -4.89200  1.000 40.90000  ? 21  SER A O    1 
ATOM   278  C CB   . SER A 1 21  ? 4.27900   -26.61100 -7.12500  1.000 41.28000  ? 21  SER A CB   1 
ATOM   279  O OG   . SER A 1 21  ? 5.44500   -25.89600 -6.75900  1.000 41.43000  ? 21  SER A OG   1 
ATOM   280  H H    . SER A 1 21  ? 2.97400   -24.13600 -7.20600  1.000 38.37000  ? 21  SER A H    1 
ATOM   281  H HA   . SER A 1 21  ? 2.34100   -26.65000 -6.44000  1.000 40.52000  ? 21  SER A HA   1 
ATOM   282  H HB2  . SER A 1 21  ? 4.35400   -27.52800 -6.82200  1.000 40.58000  ? 21  SER A HB2  1 
ATOM   283  H HB3  . SER A 1 21  ? 4.19700   -26.59400 -8.09100  1.000 40.58000  ? 21  SER A HB3  1 
ATOM   284  H HG   . SER A 1 21  ? 6.12300   -26.25800 -7.09900  1.000 49.59000  ? 21  SER A HG   1 
ATOM   285  N N    . PRO A 1 22  ? 3.82200   -26.22400 -4.19700  1.000 29.76000  ? 22  PRO A N    1 
ATOM   286  C CA   . PRO A 1 22  ? 4.21000   -25.66800 -2.88900  1.000 30.24000  ? 22  PRO A CA   1 
ATOM   287  C C    . PRO A 1 22  ? 5.26200   -24.57200 -2.97300  1.000 29.11000  ? 22  PRO A C    1 
ATOM   288  O O    . PRO A 1 22  ? 5.38700   -23.78600 -2.02500  1.000 29.74000  ? 22  PRO A O    1 
ATOM   289  C CB   . PRO A 1 22  ? 4.73400   -26.89400 -2.12700  1.000 31.82000  ? 22  PRO A CB   1 
ATOM   290  C CG   . PRO A 1 22  ? 4.00800   -28.06100 -2.75400  1.000 32.44000  ? 22  PRO A CG   1 
ATOM   291  C CD   . PRO A 1 22  ? 3.84100   -27.69900 -4.20900  1.000 31.08000  ? 22  PRO A CD   1 
ATOM   292  H HA   . PRO A 1 22  ? 3.42900   -25.32100 -2.43100  1.000 38.43000  ? 22  PRO A HA   1 
ATOM   293  H HB2  . PRO A 1 22  ? 5.69200   -26.97500 -2.25500  1.000 41.91000  ? 22  PRO A HB2  1 
ATOM   294  H HB3  . PRO A 1 22  ? 4.51700   -26.81600 -1.18500  1.000 41.91000  ? 22  PRO A HB3  1 
ATOM   295  H HG2  . PRO A 1 22  ? 4.54300   -28.86500 -2.66100  1.000 40.63000  ? 22  PRO A HG2  1 
ATOM   296  H HG3  . PRO A 1 22  ? 3.14400   -28.17400 -2.32800  1.000 40.63000  ? 22  PRO A HG3  1 
ATOM   297  H HD2  . PRO A 1 22  ? 4.59800   -28.02500 -4.71900  1.000 36.08000  ? 22  PRO A HD2  1 
ATOM   298  H HD3  . PRO A 1 22  ? 3.00300   -28.04700 -4.55100  1.000 36.08000  ? 22  PRO A HD3  1 
ATOM   299  N N    . SER A 1 23  ? 6.01200   -24.47700 -4.07600  1.000 29.95000  ? 23  SER A N    1 
ATOM   300  C CA   . SER A 1 23  ? 7.11000   -23.52600 -4.16400  1.000 29.30000  ? 23  SER A CA   1 
ATOM   301  C C    . SER A 1 23  ? 7.09700   -22.65500 -5.41400  1.000 28.23000  ? 23  SER A C    1 
ATOM   302  O O    . SER A 1 23  ? 8.04100   -21.88200 -5.61100  1.000 28.23000  ? 23  SER A O    1 
ATOM   303  C CB   . SER A 1 23  ? 8.45700   -24.26600 -4.09800  1.000 30.16000  ? 23  SER A CB   1 
ATOM   304  O OG   . SER A 1 23  ? 8.58200   -25.19400 -5.16300  1.000 29.76000  ? 23  SER A OG   1 
ATOM   305  H H    . SER A 1 23  ? 5.90200   -24.95400 -4.78300  1.000 38.69000  ? 23  SER A H    1 
ATOM   306  H HA   . SER A 1 23  ? 7.07000   -22.93000 -3.40000  1.000 36.54000  ? 23  SER A HA   1 
ATOM   307  H HB2  . SER A 1 23  ? 9.17600   -23.61800 -4.15900  1.000 38.77000  ? 23  SER A HB2  1 
ATOM   308  H HB3  . SER A 1 23  ? 8.51300   -24.74400 -3.25600  1.000 38.77000  ? 23  SER A HB3  1 
ATOM   309  H HG   . SER A 1 23  ? 9.32100   -25.59000 -5.11400  1.000 36.20000  ? 23  SER A HG   1 
ATOM   310  N N    . LEU A 1 24  ? 6.06900   -22.74500 -6.25600  1.000 32.85000  ? 24  LEU A N    1 
ATOM   311  C CA   . LEU A 1 24  ? 6.00000   -21.98000 -7.49600  1.000 31.14000  ? 24  LEU A CA   1 
ATOM   312  C C    . LEU A 1 24  ? 4.77600   -21.07700 -7.45800  1.000 30.48000  ? 24  LEU A C    1 
ATOM   313  O O    . LEU A 1 24  ? 3.64900   -21.55500 -7.27900  1.000 29.94000  ? 24  LEU A O    1 
ATOM   314  C CB   . LEU A 1 24  ? 5.95000   -22.90700 -8.71200  1.000 31.21000  ? 24  LEU A CB   1 
ATOM   315  C CG   . LEU A 1 24  ? 6.01800   -22.24700 -10.09000 1.000 29.13000  ? 24  LEU A CG   1 
ATOM   316  C CD1  . LEU A 1 24  ? 7.31000   -21.46200 -10.24100 1.000 29.28000  ? 24  LEU A CD1  1 
ATOM   317  C CD2  . LEU A 1 24  ? 5.88700   -23.29600 -11.18700 1.000 29.04000  ? 24  LEU A CD2  1 
ATOM   318  H H    . LEU A 1 24  ? 5.38700   -23.25200 -6.12700  1.000 41.47000  ? 24  LEU A H    1 
ATOM   319  H HA   . LEU A 1 24  ? 6.78700   -21.41900 -7.57300  1.000 36.82000  ? 24  LEU A HA   1 
ATOM   320  H HB2  . LEU A 1 24  ? 6.69700   -23.52300 -8.65300  1.000 44.53000  ? 24  LEU A HB2  1 
ATOM   321  H HB3  . LEU A 1 24  ? 5.12000   -23.40800 -8.67600  1.000 44.53000  ? 24  LEU A HB3  1 
ATOM   322  H HG   . LEU A 1 24  ? 5.27800   -21.62600 -10.18000 1.000 38.17000  ? 24  LEU A HG   1 
ATOM   323  H HD11 . LEU A 1 24  ? 7.41700   -21.20900 -11.17100 1.000 35.73000  ? 24  LEU A HD11 1 
ATOM   324  H HD12 . LEU A 1 24  ? 7.26600   -20.66800 -9.68500  1.000 35.73000  ? 24  LEU A HD12 1 
ATOM   325  H HD13 . LEU A 1 24  ? 8.05300   -22.02100 -9.96400  1.000 35.73000  ? 24  LEU A HD13 1 
ATOM   326  H HD21 . LEU A 1 24  ? 5.93000   -22.85600 -12.05100 1.000 40.31000  ? 24  LEU A HD21 1 
ATOM   327  H HD22 . LEU A 1 24  ? 6.61400   -23.93300 -11.10300 1.000 40.31000  ? 24  LEU A HD22 1 
ATOM   328  H HD23 . LEU A 1 24  ? 5.03600   -23.75000 -11.08900 1.000 40.31000  ? 24  LEU A HD23 1 
ATOM   329  N N    . PHE A 1 25  ? 5.00400   -19.77900 -7.64000  1.000 26.48000  ? 25  PHE A N    1 
ATOM   330  C CA   . PHE A 1 25  ? 3.97600   -18.75100 -7.55300  1.000 26.47000  ? 25  PHE A CA   1 
ATOM   331  C C    . PHE A 1 25  ? 4.04300   -17.91300 -8.82000  1.000 26.00000  ? 25  PHE A C    1 
ATOM   332  O O    . PHE A 1 25  ? 5.11500   -17.41600 -9.17800  1.000 26.83000  ? 25  PHE A O    1 
ATOM   333  C CB   . PHE A 1 25  ? 4.19400   -17.88600 -6.30600  1.000 27.68000  ? 25  PHE A CB   1 
ATOM   334  C CG   . PHE A 1 25  ? 3.04800   -16.97500 -5.98400  1.000 27.34000  ? 25  PHE A CG   1 
ATOM   335  C CD1  . PHE A 1 25  ? 1.87100   -17.48100 -5.46400  1.000 26.47000  ? 25  PHE A CD1  1 
ATOM   336  C CD2  . PHE A 1 25  ? 3.15500   -15.61100 -6.18500  1.000 28.98000  ? 25  PHE A CD2  1 
ATOM   337  C CE1  . PHE A 1 25  ? 0.81600   -16.64300 -5.16200  1.000 25.80000  ? 25  PHE A CE1  1 
ATOM   338  C CE2  . PHE A 1 25  ? 2.10400   -14.77100 -5.88600  1.000 28.45000  ? 25  PHE A CE2  1 
ATOM   339  C CZ   . PHE A 1 25  ? 0.93500   -15.28800 -5.36900  1.000 26.43000  ? 25  PHE A CZ   1 
ATOM   340  H H    . PHE A 1 25  ? 5.78100   -19.45900 -7.82300  1.000 36.19000  ? 25  PHE A H    1 
ATOM   341  H HA   . PHE A 1 25  ? 3.10000   -19.16400 -7.49800  1.000 39.14000  ? 25  PHE A HA   1 
ATOM   342  H HB2  . PHE A 1 25  ? 4.33100   -18.46900 -5.54300  1.000 31.18000  ? 25  PHE A HB2  1 
ATOM   343  H HB3  . PHE A 1 25  ? 4.98000   -17.33500 -6.44300  1.000 31.18000  ? 25  PHE A HB3  1 
ATOM   344  H HD1  . PHE A 1 25  ? 1.78700   -18.39600 -5.32100  1.000 33.21000  ? 25  PHE A HD1  1 
ATOM   345  H HD2  . PHE A 1 25  ? 3.94200   -15.25800 -6.53200  1.000 28.38000  ? 25  PHE A HD2  1 
ATOM   346  H HE1  . PHE A 1 25  ? 0.02800   -16.99300 -4.81500  1.000 32.25000  ? 25  PHE A HE1  1 
ATOM   347  H HE2  . PHE A 1 25  ? 2.18600   -13.85500 -6.02700  1.000 31.69000  ? 25  PHE A HE2  1 
ATOM   348  H HZ   . PHE A 1 25  ? 0.22500   -14.72200 -5.16700  1.000 29.80000  ? 25  PHE A HZ   1 
ATOM   349  N N    . ILE A 1 26  ? 2.91200   -17.77600 -9.51000  1.000 33.60000  ? 26  ILE A N    1 
ATOM   350  C CA   . ILE A 1 26  ? 2.85500   -17.01500 -10.75100 1.000 33.52000  ? 26  ILE A CA   1 
ATOM   351  C C    . ILE A 1 26  ? 1.93000   -15.82300 -10.55600 1.000 34.51000  ? 26  ILE A C    1 
ATOM   352  O O    . ILE A 1 26  ? 0.93900   -15.89300 -9.82300  1.000 33.94000  ? 26  ILE A O    1 
ATOM   353  C CB   . ILE A 1 26  ? 2.38000   -17.86800 -11.94900 1.000 31.94000  ? 26  ILE A CB   1 
ATOM   354  C CG1  . ILE A 1 26  ? 0.98100   -18.43100 -11.68500 1.000 31.07000  ? 26  ILE A CG1  1 
ATOM   355  C CG2  . ILE A 1 26  ? 3.36500   -18.99100 -12.23200 1.000 31.35000  ? 26  ILE A CG2  1 
ATOM   356  C CD1  . ILE A 1 26  ? 0.36600   -19.13000 -12.88400 1.000 29.54000  ? 26  ILE A CD1  1 
ATOM   357  H H    . ILE A 1 26  ? 2.15900   -18.11800 -9.27600  1.000 35.20000  ? 26  ILE A H    1 
ATOM   358  H HA   . ILE A 1 26  ? 3.73900   -16.67500 -10.96000 1.000 37.51000  ? 26  ILE A HA   1 
ATOM   359  H HB   . ILE A 1 26  ? 2.33600   -17.29700 -12.73200 1.000 43.51000  ? 26  ILE A HB   1 
ATOM   360  H HG12 . ILE A 1 26  ? 1.03500   -19.07600 -10.96200 1.000 45.49000  ? 26  ILE A HG12 1 
ATOM   361  H HG13 . ILE A 1 26  ? 0.38400   -17.70900 -11.43600 1.000 45.49000  ? 26  ILE A HG13 1 
ATOM   362  H HG21 . ILE A 1 26  ? 3.11300   -19.43400 -13.05700 1.000 39.08000  ? 26  ILE A HG21 1 
ATOM   363  H HG22 . ILE A 1 26  ? 4.25500   -18.61400 -12.31800 1.000 39.08000  ? 26  ILE A HG22 1 
ATOM   364  H HG23 . ILE A 1 26  ? 3.34400   -19.62200 -11.49600 1.000 39.08000  ? 26  ILE A HG23 1 
ATOM   365  H HD11 . ILE A 1 26  ? -0.55600  -19.35300 -12.68000 1.000 40.59000  ? 26  ILE A HD11 1 
ATOM   366  H HD12 . ILE A 1 26  ? 0.40100   -18.53400 -13.64800 1.000 40.59000  ? 26  ILE A HD12 1 
ATOM   367  H HD13 . ILE A 1 26  ? 0.86900   -19.93800 -13.07100 1.000 40.59000  ? 26  ILE A HD13 1 
ATOM   368  N N    . THR A 1 27  ? 2.25000   -14.72700 -11.24100 1.000 29.75000  ? 27  THR A N    1 
ATOM   369  C CA   . THR A 1 27  ? 1.44900   -13.51300 -11.16500 1.000 31.09000  ? 27  THR A CA   1 
ATOM   370  C C    . THR A 1 27  ? 1.74000   -12.65800 -12.39500 1.000 31.03000  ? 27  THR A C    1 
ATOM   371  O O    . THR A 1 27  ? 2.54200   -13.02800 -13.25800 1.000 29.42000  ? 27  THR A O    1 
ATOM   372  C CB   . THR A 1 27  ? 1.73900   -12.74400 -9.87200  1.000 31.66000  ? 27  THR A CB   1 
ATOM   373  O OG1  . THR A 1 27  ? 0.81100   -11.66100 -9.73100  1.000 31.63000  ? 27  THR A OG1  1 
ATOM   374  C CG2  . THR A 1 27  ? 3.15900   -12.19000 -9.88700  1.000 32.66000  ? 27  THR A CG2  1 
ATOM   375  H H    . THR A 1 27  ? 2.93200   -14.66300 -11.76000 1.000 38.26000  ? 27  THR A H    1 
ATOM   376  H HA   . THR A 1 27  ? 0.50800   -13.74900 -11.17400 1.000 36.76000  ? 27  THR A HA   1 
ATOM   377  H HB   . THR A 1 27  ? 1.65200   -13.34300 -9.11400  1.000 34.95000  ? 27  THR A HB   1 
ATOM   378  H HG1  . THR A 1 27  ? 0.02600   -11.95800 -9.70300  1.000 37.60000  ? 27  THR A HG1  1 
ATOM   379  H HG21 . THR A 1 27  ? 3.40100   -11.87500 -9.00200  1.000 38.98000  ? 27  THR A HG21 1 
ATOM   380  H HG22 . THR A 1 27  ? 3.78300   -12.88200 -10.15600 1.000 38.98000  ? 27  THR A HG22 1 
ATOM   381  H HG23 . THR A 1 27  ? 3.22100   -11.45100 -10.51100 1.000 38.98000  ? 27  THR A HG23 1 
ATOM   382  N N    . SER A 1 28  ? 1.06600   -11.51100 -12.47200 1.000 36.35000  ? 28  SER A N    1 
ATOM   383  C CA   . SER A 1 28  ? 1.32500   -10.51800 -13.50400 1.000 36.25000  ? 28  SER A CA   1 
ATOM   384  C C    . SER A 1 28  ? 2.44900   -9.59900  -13.04700 1.000 37.17000  ? 28  SER A C    1 
ATOM   385  O O    . SER A 1 28  ? 2.48500   -9.17100  -11.89000 1.000 38.21000  ? 28  SER A O    1 
ATOM   386  C CB   . SER A 1 28  ? 0.06900   -9.69900  -13.80400 1.000 37.34000  ? 28  SER A CB   1 
ATOM   387  O OG   . SER A 1 28  ? 0.30800   -8.77200  -14.85000 1.000 37.88000  ? 28  SER A OG   1 
ATOM   388  H H    . SER A 1 28  ? 0.44200   -11.28400 -11.92500 1.000 44.16000  ? 28  SER A H    1 
ATOM   389  H HA   . SER A 1 28  ? 1.60300   -10.96400 -14.31900 1.000 39.85000  ? 28  SER A HA   1 
ATOM   390  H HB2  . SER A 1 28  ? -0.64300  -10.30100 -14.07300 1.000 46.65000  ? 28  SER A HB2  1 
ATOM   391  H HB3  . SER A 1 28  ? -0.19000  -9.21500  -13.00500 1.000 46.65000  ? 28  SER A HB3  1 
ATOM   392  H HG   . SER A 1 28  ? 0.55800   -9.17800  -15.54200 1.000 50.28000  ? 28  SER A HG   1 
ATOM   393  N N    . THR A 1 29  ? 3.36400   -9.28900  -13.96500 1.000 43.62000  ? 29  THR A N    1 
ATOM   394  C CA   . THR A 1 29  ? 4.58900   -8.60200  -13.56900 1.000 44.53000  ? 29  THR A CA   1 
ATOM   395  C C    . THR A 1 29  ? 4.29800   -7.23300  -12.96400 1.000 45.39000  ? 29  THR A C    1 
ATOM   396  O O    . THR A 1 29  ? 4.91200   -6.84700  -11.96200 1.000 45.85000  ? 29  THR A O    1 
ATOM   397  C CB   . THR A 1 29  ? 5.52700   -8.45700  -14.76900 1.000 43.79000  ? 29  THR A CB   1 
ATOM   398  O OG1  . THR A 1 29  ? 5.90100   -9.75500  -15.24900 1.000 43.26000  ? 29  THR A OG1  1 
ATOM   399  C CG2  . THR A 1 29  ? 6.77800   -7.68100  -14.37600 1.000 45.01000  ? 29  THR A CG2  1 
ATOM   400  H H    . THR A 1 29  ? 3.30100   -9.46100  -14.80500 1.000 49.35000  ? 29  THR A H    1 
ATOM   401  H HA   . THR A 1 29  ? 5.04400   -9.13400  -12.89700 1.000 51.89000  ? 29  THR A HA   1 
ATOM   402  H HB   . THR A 1 29  ? 5.07400   -7.97000  -15.47500 1.000 45.63000  ? 29  THR A HB   1 
ATOM   403  H HG1  . THR A 1 29  ? 6.41600   -9.68000  -15.90800 1.000 51.03000  ? 29  THR A HG1  1 
ATOM   404  H HG21 . THR A 1 29  ? 7.47200   -7.81700  -15.04000 1.000 49.64000  ? 29  THR A HG21 1 
ATOM   405  H HG22 . THR A 1 29  ? 6.58000   -6.73300  -14.31900 1.000 49.64000  ? 29  THR A HG22 1 
ATOM   406  H HG23 . THR A 1 29  ? 7.10300   -7.99000  -13.51600 1.000 49.64000  ? 29  THR A HG23 1 
ATOM   407  N N    . HIS A 1 30  ? 3.37100   -6.48100  -13.55600 1.000 47.27000  ? 30  HIS A N    1 
ATOM   408  C CA   . HIS A 1 30  ? 3.16300   -5.08900  -13.18300 1.000 47.49000  ? 30  HIS A CA   1 
ATOM   409  C C    . HIS A 1 30  ? 2.04300   -4.90400  -12.16600 1.000 47.26000  ? 30  HIS A C    1 
ATOM   410  O O    . HIS A 1 30  ? 1.47900   -3.80900  -12.07000 1.000 48.09000  ? 30  HIS A O    1 
ATOM   411  C CB   . HIS A 1 30  ? 2.88800   -4.24600  -14.42600 1.000 48.97000  ? 30  HIS A CB   1 
ATOM   412  C CG   . HIS A 1 30  ? 4.10700   -3.97400  -15.25100 1.000 49.30000  ? 30  HIS A CG   1 
ATOM   413  N ND1  . HIS A 1 30  ? 4.50400   -4.79400  -16.28500 1.000 48.81000  ? 30  HIS A ND1  1 
ATOM   414  C CD2  . HIS A 1 30  ? 5.01900   -2.97500  -15.18900 1.000 49.65000  ? 30  HIS A CD2  1 
ATOM   415  C CE1  . HIS A 1 30  ? 5.60600   -4.30900  -16.82900 1.000 49.25000  ? 30  HIS A CE1  1 
ATOM   416  N NE2  . HIS A 1 30  ? 5.94000   -3.20600  -16.18200 1.000 50.27000  ? 30  HIS A NE2  1 
ATOM   417  H H    . HIS A 1 30  ? 2.84800   -6.75800  -14.18000 1.000 52.94000  ? 30  HIS A H    1 
ATOM   418  H HA   . HIS A 1 30  ? 3.97900   -4.75300  -12.78000 1.000 49.33000  ? 30  HIS A HA   1 
ATOM   419  H HB2  . HIS A 1 30  ? 2.25300   -4.71500  -14.98900 1.000 63.03000  ? 30  HIS A HB2  1 
ATOM   420  H HB3  . HIS A 1 30  ? 2.52000   -3.39100  -14.15600 1.000 63.03000  ? 30  HIS A HB3  1 
ATOM   421  H HD2  . HIS A 1 30  ? 5.02000   -2.26400  -14.58900 1.000 56.52000  ? 30  HIS A HD2  1 
ATOM   422  H HE1  . HIS A 1 30  ? 6.06900   -4.68200  -17.54400 1.000 61.26000  ? 30  HIS A HE1  1 
ATOM   423  H HE2  . HIS A 1 30  ? 6.62300   -2.71300  -16.35400 1.000 51.57000  ? 30  HIS A HE2  1 
ATOM   424  N N    . VAL A 1 31  ? 1.70500   -5.94700  -11.40600 1.000 40.10000  ? 31  VAL A N    1 
ATOM   425  C CA   . VAL A 1 31  ? 0.90200   -5.77700  -10.20200 1.000 39.58000  ? 31  VAL A CA   1 
ATOM   426  C C    . VAL A 1 31  ? 1.74900   -5.85900  -8.94300  1.000 39.87000  ? 31  VAL A C    1 
ATOM   427  O O    . VAL A 1 31  ? 1.21600   -5.71400  -7.83500  1.000 39.87000  ? 31  VAL A O    1 
ATOM   428  C CB   . VAL A 1 31  ? -0.24100  -6.81100  -10.13100 1.000 38.90000  ? 31  VAL A CB   1 
ATOM   429  C CG1  . VAL A 1 31  ? -1.00800  -6.85600  -11.44300 1.000 39.25000  ? 31  VAL A CG1  1 
ATOM   430  C CG2  . VAL A 1 31  ? 0.29900   -8.18500  -9.76000  1.000 38.54000  ? 31  VAL A CG2  1 
ATOM   431  H H    . VAL A 1 31  ? 1.92900   -6.76100  -11.56800 1.000 49.52000  ? 31  VAL A H    1 
ATOM   432  H HA   . VAL A 1 31  ? 0.49400   -4.89700  -10.22000 1.000 47.26000  ? 31  VAL A HA   1 
ATOM   433  H HB   . VAL A 1 31  ? -0.86200  -6.54100  -9.43600  1.000 46.88000  ? 31  VAL A HB   1 
ATOM   434  H HG11 . VAL A 1 31  ? -1.74700  -7.47800  -11.35400 1.000 48.93000  ? 31  VAL A HG11 1 
ATOM   435  H HG12 . VAL A 1 31  ? -1.34500  -5.96800  -11.64100 1.000 48.93000  ? 31  VAL A HG12 1 
ATOM   436  H HG13 . VAL A 1 31  ? -0.41300  -7.14900  -12.15000 1.000 48.93000  ? 31  VAL A HG13 1 
ATOM   437  H HG21 . VAL A 1 31  ? -0.30300  -8.86500  -10.10100 1.000 45.49000  ? 31  VAL A HG21 1 
ATOM   438  H HG22 . VAL A 1 31  ? 1.17800   -8.29300  -10.15200 1.000 45.49000  ? 31  VAL A HG22 1 
ATOM   439  H HG23 . VAL A 1 31  ? 0.36000   -8.24900  -8.79400  1.000 45.49000  ? 31  VAL A HG23 1 
ATOM   440  N N    . ILE A 1 32  ? 3.05400   -6.07200  -9.08200  1.000 40.79000  ? 32  ILE A N    1 
ATOM   441  C CA   . ILE A 1 32  ? 3.95800   -6.30000  -7.95700  1.000 40.84000  ? 32  ILE A CA   1 
ATOM   442  C C    . ILE A 1 32  ? 4.53500   -4.96100  -7.51500  1.000 42.46000  ? 32  ILE A C    1 
ATOM   443  O O    . ILE A 1 32  ? 4.94600   -4.15800  -8.36600  1.000 42.75000  ? 32  ILE A O    1 
ATOM   444  C CB   . ILE A 1 32  ? 5.07600   -7.28300  -8.34200  1.000 41.27000  ? 32  ILE A CB   1 
ATOM   445  C CG1  . ILE A 1 32  ? 4.46500   -8.52700  -8.99000  1.000 41.09000  ? 32  ILE A CG1  1 
ATOM   446  C CG2  . ILE A 1 32  ? 5.90900   -7.65800  -7.12300  1.000 42.52000  ? 32  ILE A CG2  1 
ATOM   447  C CD1  . ILE A 1 32  ? 5.45000   -9.39100  -9.71800  1.000 41.52000  ? 32  ILE A CD1  1 
ATOM   448  H H    . ILE A 1 32  ? 3.45500   -6.08900  -9.84200  1.000 52.31000  ? 32  ILE A H    1 
ATOM   449  H HA   . ILE A 1 32  ? 3.45200   -6.68900  -7.22900  1.000 48.98000  ? 32  ILE A HA   1 
ATOM   450  H HB   . ILE A 1 32  ? 5.65500   -6.85200  -8.99000  1.000 49.59000  ? 32  ILE A HB   1 
ATOM   451  H HG12 . ILE A 1 32  ? 4.05500   -9.06700  -8.29700  1.000 53.22000  ? 32  ILE A HG12 1 
ATOM   452  H HG13 . ILE A 1 32  ? 3.79400   -8.26300  -9.63600  1.000 53.22000  ? 32  ILE A HG13 1 
ATOM   453  H HG21 . ILE A 1 32  ? 6.61200   -8.26700  -7.39800  1.000 59.06000  ? 32  ILE A HG21 1 
ATOM   454  H HG22 . ILE A 1 32  ? 6.29800   -6.85500  -6.74300  1.000 59.06000  ? 32  ILE A HG22 1 
ATOM   455  H HG23 . ILE A 1 32  ? 5.33600   -8.08900  -6.47000  1.000 59.06000  ? 32  ILE A HG23 1 
ATOM   456  H HD11 . ILE A 1 32  ? 4.97100   -10.09100 -10.18700 1.000 56.12000  ? 32  ILE A HD11 1 
ATOM   457  H HD12 . ILE A 1 32  ? 5.94000   -8.84400  -10.35100 1.000 56.12000  ? 32  ILE A HD12 1 
ATOM   458  H HD13 . ILE A 1 32  ? 6.06200   -9.78100  -9.07500  1.000 56.12000  ? 32  ILE A HD13 1 
ATOM   459  N N    . PRO A 1 33  ? 4.59000   -4.67400  -6.21600  1.000 63.38000  ? 33  PRO A N    1 
ATOM   460  C CA   . PRO A 1 33  ? 5.17100   -3.39700  -5.77500  1.000 64.65000  ? 33  PRO A CA   1 
ATOM   461  C C    . PRO A 1 33  ? 6.63300   -3.29100  -6.18900  1.000 66.30000  ? 33  PRO A C    1 
ATOM   462  O O    . PRO A 1 33  ? 7.41700   -4.22700  -6.01400  1.000 65.80000  ? 33  PRO A O    1 
ATOM   463  C CB   . PRO A 1 33  ? 5.00300   -3.43400  -4.25000  1.000 65.04000  ? 33  PRO A CB   1 
ATOM   464  C CG   . PRO A 1 33  ? 4.83700   -4.89600  -3.90400  1.000 63.67000  ? 33  PRO A CG   1 
ATOM   465  C CD   . PRO A 1 33  ? 4.14000   -5.51000  -5.08500  1.000 62.73000  ? 33  PRO A CD   1 
ATOM   466  H HA   . PRO A 1 33  ? 4.67200   -2.65000  -6.14000  1.000 72.70000  ? 33  PRO A HA   1 
ATOM   467  H HB2  . PRO A 1 33  ? 5.79500   -3.06900  -3.82500  1.000 72.43000  ? 33  PRO A HB2  1 
ATOM   468  H HB3  . PRO A 1 33  ? 4.21400   -2.93000  -3.99600  1.000 72.43000  ? 33  PRO A HB3  1 
ATOM   469  H HG2  . PRO A 1 33  ? 5.70400   -5.30200  -3.77400  1.000 70.58000  ? 33  PRO A HG2  1 
ATOM   470  H HG3  . PRO A 1 33  ? 4.29500   -4.98200  -3.10400  1.000 70.58000  ? 33  PRO A HG3  1 
ATOM   471  H HD2  . PRO A 1 33  ? 4.42600   -6.42900  -5.20200  1.000 65.53000  ? 33  PRO A HD2  1 
ATOM   472  H HD3  . PRO A 1 33  ? 3.17800   -5.44700  -4.98000  1.000 65.53000  ? 33  PRO A HD3  1 
ATOM   473  N N    . GLN A 1 34  ? 6.99500   -2.13500  -6.75200  1.000 93.03000  ? 34  GLN A N    1 
ATOM   474  C CA   . GLN A 1 34  ? 8.33900   -1.93800  -7.28300  1.000 95.18000  ? 34  GLN A CA   1 
ATOM   475  C C    . GLN A 1 34  ? 9.40800   -1.89600  -6.20000  1.000 97.34000  ? 34  GLN A C    1 
ATOM   476  O O    . GLN A 1 34  ? 10.59800  -1.96000  -6.52700  1.000 99.21000  ? 34  GLN A O    1 
ATOM   477  C CB   . GLN A 1 34  ? 8.39300   -0.64700  -8.10500  1.000 98.11000  ? 34  GLN A CB   1 
ATOM   478  C CG   . GLN A 1 34  ? 7.51500   -0.67200  -9.34700  1.000 97.72000  ? 34  GLN A CG   1 
ATOM   479  C CD   . GLN A 1 34  ? 7.48300   0.65700   -10.07900 1.000 102.41000 ? 34  GLN A CD   1 
ATOM   480  O OE1  . GLN A 1 34  ? 7.72000   1.71300   -9.49000  1.000 106.05000 ? 34  GLN A OE1  1 
ATOM   481  N NE2  . GLN A 1 34  ? 7.18900   0.61000   -11.37400 1.000 101.75000 ? 34  GLN A NE2  1 
ATOM   482  H H    . GLN A 1 34  ? 6.47900   -1.45200  -6.83700  1.000 95.51000  ? 34  GLN A H    1 
ATOM   483  H HA   . GLN A 1 34  ? 8.55000   -2.67600  -7.87700  1.000 100.06000 ? 34  GLN A HA   1 
ATOM   484  H HB2  . GLN A 1 34  ? 8.09800   0.09000   -7.54800  1.000 104.01000 ? 34  GLN A HB2  1 
ATOM   485  H HB3  . GLN A 1 34  ? 9.30800   -0.49700  -8.39100  1.000 104.01000 ? 34  GLN A HB3  1 
ATOM   486  H HG2  . GLN A 1 34  ? 7.85500   -1.34300  -9.96000  1.000 115.71000 ? 34  GLN A HG2  1 
ATOM   487  H HG3  . GLN A 1 34  ? 6.60700   -0.89200  -9.08700  1.000 115.71000 ? 34  GLN A HG3  1 
ATOM   488  H HE21 . GLN A 1 34  ? 7.02900   -0.14600  -11.75200 1.000 135.12000 ? 34  GLN A HE21 1 
ATOM   489  H HE22 . GLN A 1 34  ? 7.15800   1.33600   -11.83500 1.000 135.12000 ? 34  GLN A HE22 1 
ATOM   490  N N    . GLY A 1 35  ? 9.02100   -1.79100  -4.93200  1.000 72.14000  ? 35  GLY A N    1 
ATOM   491  C CA   . GLY A 1 35  ? 9.98500   -1.75800  -3.85300  1.000 73.70000  ? 35  GLY A CA   1 
ATOM   492  C C    . GLY A 1 35  ? 9.80800   -2.90200  -2.87700  1.000 71.92000  ? 35  GLY A C    1 
ATOM   493  O O    . GLY A 1 35  ? 9.81100   -2.69600  -1.66000  1.000 73.51000  ? 35  GLY A O    1 
ATOM   494  H H    . GLY A 1 35  ? 8.20200   -1.73700  -4.67400  1.000 89.18000  ? 35  GLY A H    1 
ATOM   495  H HA2  . GLY A 1 35  ? 10.88500  -1.80100  -4.21200  1.000 84.97000  ? 35  GLY A HA2  1 
ATOM   496  H HA3  . GLY A 1 35  ? 9.89100   -0.92500  -3.36500  1.000 84.97000  ? 35  GLY A HA3  1 
ATOM   497  N N    . ALA A 1 36  ? 9.65600   -4.11400  -3.40200  1.000 66.15000  ? 36  ALA A N    1 
ATOM   498  C CA   . ALA A 1 36  ? 9.46900   -5.30000  -2.57800  1.000 64.31000  ? 36  ALA A CA   1 
ATOM   499  C C    . ALA A 1 36  ? 10.82100  -5.95800  -2.33100  1.000 64.79000  ? 36  ALA A C    1 
ATOM   500  O O    . ALA A 1 36  ? 11.51500  -6.33500  -3.28100  1.000 64.86000  ? 36  ALA A O    1 
ATOM   501  C CB   . ALA A 1 36  ? 8.50800   -6.27800  -3.25300  1.000 63.01000  ? 36  ALA A CB   1 
ATOM   502  H H    . ALA A 1 36  ? 9.65800   -4.27600  -4.24700  1.000 75.91000  ? 36  ALA A H    1 
ATOM   503  H HA   . ALA A 1 36  ? 9.09200   -5.04300  -1.72200  1.000 74.57000  ? 36  ALA A HA   1 
ATOM   504  H HB1  . ALA A 1 36  ? 8.37300   -7.04200  -2.67100  1.000 75.84000  ? 36  ALA A HB1  1 
ATOM   505  H HB2  . ALA A 1 36  ? 7.66800   -5.82800  -3.40900  1.000 75.84000  ? 36  ALA A HB2  1 
ATOM   506  H HB3  . ALA A 1 36  ? 8.89100   -6.56600  -4.09600  1.000 75.84000  ? 36  ALA A HB3  1 
ATOM   507  N N    . LYS A 1 37  ? 11.19900  -6.08100  -1.05800  1.000 66.72000  ? 37  LYS A N    1 
ATOM   508  C CA   . LYS A 1 37  ? 12.42500  -6.76400  -0.66900  1.000 67.36000  ? 37  LYS A CA   1 
ATOM   509  C C    . LYS A 1 37  ? 12.15500  -8.13600  -0.05900  1.000 65.96000  ? 37  LYS A C    1 
ATOM   510  O O    . LYS A 1 37  ? 13.09400  -8.79200  0.40500   1.000 67.35000  ? 37  LYS A O    1 
ATOM   511  C CB   . LYS A 1 37  ? 13.23500  -5.91200  0.31800   1.000 71.21000  ? 37  LYS A CB   1 
ATOM   512  C CG   . LYS A 1 37  ? 13.99500  -4.73600  -0.29600  1.000 74.09000  ? 37  LYS A CG   1 
ATOM   513  C CD   . LYS A 1 37  ? 13.08800  -3.52600  -0.46700  1.000 76.23000  ? 37  LYS A CD   1 
ATOM   514  C CE   . LYS A 1 37  ? 13.68900  -2.48700  -1.40500  1.000 78.90000  ? 37  LYS A CE   1 
ATOM   515  N NZ   . LYS A 1 37  ? 12.71100  -1.40300  -1.71800  1.000 80.22000  ? 37  LYS A NZ   1 
ATOM   516  H H    . LYS A 1 37  ? 10.75200  -5.77000  -0.39200  1.000 65.07000  ? 37  LYS A H    1 
ATOM   517  H HA   . LYS A 1 37  ? 12.97300  -6.89700  -1.45800  1.000 61.91000  ? 37  LYS A HA   1 
ATOM   518  H HB2  . LYS A 1 37  ? 12.62700  -5.55000  0.98200   1.000 67.55000  ? 37  LYS A HB2  1 
ATOM   519  H HB3  . LYS A 1 37  ? 13.88700  -6.48300  0.75400   1.000 67.55000  ? 37  LYS A HB3  1 
ATOM   520  H HG2  . LYS A 1 37  ? 14.72800  -4.48700  0.28800   1.000 70.06000  ? 37  LYS A HG2  1 
ATOM   521  H HG3  . LYS A 1 37  ? 14.33100  -4.99100  -1.16900  1.000 70.06000  ? 37  LYS A HG3  1 
ATOM   522  H HD2  . LYS A 1 37  ? 12.23900  -3.80900  -0.83900  1.000 86.90000  ? 37  LYS A HD2  1 
ATOM   523  H HD3  . LYS A 1 37  ? 12.95000  -3.10800  0.39700   1.000 86.90000  ? 37  LYS A HD3  1 
ATOM   524  H HE2  . LYS A 1 37  ? 14.46800  -2.09100  -0.98600  1.000 91.56000  ? 37  LYS A HE2  1 
ATOM   525  H HE3  . LYS A 1 37  ? 13.95200  -2.91300  -2.23400  1.000 91.56000  ? 37  LYS A HE3  1 
ATOM   526  H HZ1  . LYS A 1 37  ? 12.41200  -1.03600  -0.96400  1.000 100.81000 ? 37  LYS A HZ1  1 
ATOM   527  H HZ2  . LYS A 1 37  ? 13.10200  -0.77400  -2.21200  1.000 100.81000 ? 37  LYS A HZ2  1 
ATOM   528  H HZ3  . LYS A 1 37  ? 12.02100  -1.73800  -2.16900  1.000 100.81000 ? 37  LYS A HZ3  1 
ATOM   529  N N    . GLU A 1 38  ? 10.89900  -8.58100  -0.03500  1.000 66.91000  ? 38  GLU A N    1 
ATOM   530  C CA   . GLU A 1 38  ? 10.56500  -9.89800  0.48900   1.000 66.30000  ? 38  GLU A CA   1 
ATOM   531  C C    . GLU A 1 38  ? 9.16000   -10.27200 0.03700   1.000 64.76000  ? 38  GLU A C    1 
ATOM   532  O O    . GLU A 1 38  ? 8.30200   -9.40300  -0.14200  1.000 64.11000  ? 38  GLU A O    1 
ATOM   533  C CB   . GLU A 1 38  ? 10.66600  -9.93000  2.02000   1.000 66.83000  ? 38  GLU A CB   1 
ATOM   534  C CG   . GLU A 1 38  ? 9.38800   -9.54600  2.75100   1.000 66.59000  ? 38  GLU A CG   1 
ATOM   535  C CD   . GLU A 1 38  ? 8.56000   -10.75700 3.13100   1.000 66.12000  ? 38  GLU A CD   1 
ATOM   536  O OE1  . GLU A 1 38  ? 9.11400   -11.87600 3.11600   1.000 66.63000  ? 38  GLU A OE1  1 
ATOM   537  O OE2  . GLU A 1 38  ? 7.36100   -10.59600 3.44100   1.000 65.73000  ? 38  GLU A OE2  1 
ATOM   538  H H    . GLU A 1 38  ? 10.22000  -8.13600  -0.31800  1.000 63.48000  ? 38  GLU A H    1 
ATOM   539  H HA   . GLU A 1 38  ? 11.18500  -10.55200 0.13000   1.000 59.86000  ? 38  GLU A HA   1 
ATOM   540  H HB2  . GLU A 1 38  ? 10.92700  -10.82100 2.29600   1.000 63.95000  ? 38  GLU A HB2  1 
ATOM   541  H HB3  . GLU A 1 38  ? 11.35100  -9.29900  2.29200   1.000 63.95000  ? 38  GLU A HB3  1 
ATOM   542  H HG2  . GLU A 1 38  ? 9.62900   -9.08900  3.57200   1.000 69.83000  ? 38  GLU A HG2  1 
ATOM   543  H HG3  . GLU A 1 38  ? 8.84800   -8.95800  2.20100   1.000 69.83000  ? 38  GLU A HG3  1 
ATOM   544  N N    . PHE A 1 39  ? 8.93800   -11.57500 -0.14300  1.000 44.04000  ? 39  PHE A N    1 
ATOM   545  C CA   . PHE A 1 39  ? 7.61700   -12.10800 -0.45700  1.000 43.39000  ? 39  PHE A CA   1 
ATOM   546  C C    . PHE A 1 39  ? 7.34500   -13.31700 0.42300   1.000 43.30000  ? 39  PHE A C    1 
ATOM   547  O O    . PHE A 1 39  ? 8.16000   -14.24200 0.47700   1.000 43.83000  ? 39  PHE A O    1 
ATOM   548  C CB   . PHE A 1 39  ? 7.49600   -12.51500 -1.93300  1.000 43.73000  ? 39  PHE A CB   1 
ATOM   549  C CG   . PHE A 1 39  ? 7.56000   -11.36100 -2.88800  1.000 43.93000  ? 39  PHE A CG   1 
ATOM   550  C CD1  . PHE A 1 39  ? 6.66400   -10.31300 -2.78400  1.000 43.58000  ? 39  PHE A CD1  1 
ATOM   551  C CD2  . PHE A 1 39  ? 8.51100   -11.32800 -3.89400  1.000 43.89000  ? 39  PHE A CD2  1 
ATOM   552  C CE1  . PHE A 1 39  ? 6.71900   -9.24600  -3.65600  1.000 42.94000  ? 39  PHE A CE1  1 
ATOM   553  C CE2  . PHE A 1 39  ? 8.57000   -10.26400 -4.77200  1.000 43.90000  ? 39  PHE A CE2  1 
ATOM   554  C CZ   . PHE A 1 39  ? 7.67200   -9.22200  -4.65200  1.000 43.76000  ? 39  PHE A CZ   1 
ATOM   555  H H    . PHE A 1 39  ? 9.54900   -12.17800 -0.08700  1.000 48.32000  ? 39  PHE A H    1 
ATOM   556  H HA   . PHE A 1 39  ? 6.94400   -11.43700 -0.26600  1.000 49.82000  ? 39  PHE A HA   1 
ATOM   557  H HB2  . PHE A 1 39  ? 8.22200   -13.12000 -2.15100  1.000 55.25000  ? 39  PHE A HB2  1 
ATOM   558  H HB3  . PHE A 1 39  ? 6.64500   -12.96200 -2.06500  1.000 55.25000  ? 39  PHE A HB3  1 
ATOM   559  H HD1  . PHE A 1 39  ? 6.02100   -10.32400 -2.11200  1.000 61.29000  ? 39  PHE A HD1  1 
ATOM   560  H HD2  . PHE A 1 39  ? 9.11900   -12.02700 -3.97600  1.000 53.65000  ? 39  PHE A HD2  1 
ATOM   561  H HE1  . PHE A 1 39  ? 6.11200   -8.54600  -3.57500  1.000 54.08000  ? 39  PHE A HE1  1 
ATOM   562  H HE2  . PHE A 1 39  ? 9.21300   -10.24900 -5.44300  1.000 54.38000  ? 39  PHE A HE2  1 
ATOM   563  H HZ   . PHE A 1 39  ? 7.70900   -8.50500  -5.24400  1.000 58.02000  ? 39  PHE A HZ   1 
ATOM   564  N N    . PHE A 1 40  ? 6.20100   -13.30900 1.10600   1.000 43.35000  ? 40  PHE A N    1 
ATOM   565  C CA   . PHE A 1 40  ? 5.74200   -14.45700 1.88800   1.000 43.39000  ? 40  PHE A CA   1 
ATOM   566  C C    . PHE A 1 40  ? 6.74200   -14.85600 2.97000   1.000 44.24000  ? 40  PHE A C    1 
ATOM   567  O O    . PHE A 1 40  ? 6.81700   -16.02500 3.35700   1.000 44.36000  ? 40  PHE A O    1 
ATOM   568  C CB   . PHE A 1 40  ? 5.45000   -15.66100 0.98600   1.000 42.70000  ? 40  PHE A CB   1 
ATOM   569  C CG   . PHE A 1 40  ? 4.43200   -15.38700 -0.08100  1.000 42.14000  ? 40  PHE A CG   1 
ATOM   570  C CD1  . PHE A 1 40  ? 3.08100   -15.42000 0.21100   1.000 40.54000  ? 40  PHE A CD1  1 
ATOM   571  C CD2  . PHE A 1 40  ? 4.82600   -15.10000 -1.37700  1.000 42.41000  ? 40  PHE A CD2  1 
ATOM   572  C CE1  . PHE A 1 40  ? 2.14100   -15.16800 -0.76600  1.000 39.47000  ? 40  PHE A CE1  1 
ATOM   573  C CE2  . PHE A 1 40  ? 3.89000   -14.84700 -2.35800  1.000 41.24000  ? 40  PHE A CE2  1 
ATOM   574  C CZ   . PHE A 1 40  ? 2.54600   -14.88100 -2.05200  1.000 39.70000  ? 40  PHE A CZ   1 
ATOM   575  H H    . PHE A 1 40  ? 5.66400   -12.63800 1.13300   1.000 52.59000  ? 40  PHE A H    1 
ATOM   576  H HA   . PHE A 1 40  ? 4.91300   -14.21600 2.33100   1.000 54.72000  ? 40  PHE A HA   1 
ATOM   577  H HB2  . PHE A 1 40  ? 6.27300   -15.93100 0.54900   1.000 46.87000  ? 40  PHE A HB2  1 
ATOM   578  H HB3  . PHE A 1 40  ? 5.11600   -16.38800 1.53400   1.000 46.87000  ? 40  PHE A HB3  1 
ATOM   579  H HD1  . PHE A 1 40  ? 2.80300   -15.61200 1.07700   1.000 40.28000  ? 40  PHE A HD1  1 
ATOM   580  H HD2  . PHE A 1 40  ? 5.73100   -15.07400 -1.58800  1.000 48.81000  ? 40  PHE A HD2  1 
ATOM   581  H HE1  . PHE A 1 40  ? 1.23500   -15.19200 -0.55800  1.000 39.72000  ? 40  PHE A HE1  1 
ATOM   582  H HE2  . PHE A 1 40  ? 4.16500   -14.65400 -3.22500  1.000 42.40000  ? 40  PHE A HE2  1 
ATOM   583  H HZ   . PHE A 1 40  ? 1.91400   -14.71200 -2.71300  1.000 39.63000  ? 40  PHE A HZ   1 
ATOM   584  N N    . GLY A 1 41  ? 7.51600   -13.89700 3.47200   1.000 31.64000  ? 41  GLY A N    1 
ATOM   585  C CA   . GLY A 1 41  ? 8.49200   -14.16700 4.50400   1.000 33.80000  ? 41  GLY A CA   1 
ATOM   586  C C    . GLY A 1 41  ? 9.88100   -14.48000 3.99700   1.000 34.13000  ? 41  GLY A C    1 
ATOM   587  O O    . GLY A 1 41  ? 10.80900  -14.58100 4.81500   1.000 36.24000  ? 41  GLY A O    1 
ATOM   588  H H    . GLY A 1 41  ? 7.48800   -13.07500 3.22400   1.000 54.27000  ? 41  GLY A H    1 
ATOM   589  H HA2  . GLY A 1 41  ? 8.55500   -13.39400 5.08700   1.000 53.88000  ? 41  GLY A HA2  1 
ATOM   590  H HA3  . GLY A 1 41  ? 8.19100   -14.92000 5.03600   1.000 53.88000  ? 41  GLY A HA3  1 
ATOM   591  N N    . VAL A 1 42  ? 10.06200  -14.61700 2.69600   1.000 48.37000  ? 42  VAL A N    1 
ATOM   592  C CA   . VAL A 1 42  ? 11.33400  -15.00500 2.09600   1.000 48.35000  ? 42  VAL A CA   1 
ATOM   593  C C    . VAL A 1 42  ? 11.99200  -13.76500 1.49600   1.000 49.00000  ? 42  VAL A C    1 
ATOM   594  O O    . VAL A 1 42  ? 11.31900  -13.03900 0.74600   1.000 48.63000  ? 42  VAL A O    1 
ATOM   595  C CB   . VAL A 1 42  ? 11.14200  -16.09300 1.02500   1.000 47.58000  ? 42  VAL A CB   1 
ATOM   596  C CG1  . VAL A 1 42  ? 12.48600  -16.59400 0.52500   1.000 47.88000  ? 42  VAL A CG1  1 
ATOM   597  C CG2  . VAL A 1 42  ? 10.29100  -17.24000 1.56900   1.000 47.11000  ? 42  VAL A CG2  1 
ATOM   598  H H    . VAL A 1 42  ? 9.44200   -14.48700 2.11500   1.000 63.46000  ? 42  VAL A H    1 
ATOM   599  H HA   . VAL A 1 42  ? 11.90300  -15.37200 2.78700   1.000 56.59000  ? 42  VAL A HA   1 
ATOM   600  H HB   . VAL A 1 42  ? 10.67000  -15.70800 0.27000   1.000 52.04000  ? 42  VAL A HB   1 
ATOM   601  H HG11 . VAL A 1 42  ? 12.34000  -17.34800 -0.06800  1.000 50.46000  ? 42  VAL A HG11 1 
ATOM   602  H HG12 . VAL A 1 42  ? 12.93300  -15.87900 0.04600   1.000 50.46000  ? 42  VAL A HG12 1 
ATOM   603  H HG13 . VAL A 1 42  ? 13.02200  -16.87000 1.28500   1.000 50.46000  ? 42  VAL A HG13 1 
ATOM   604  H HG21 . VAL A 1 42  ? 10.30400  -17.97200 0.93300   1.000 51.16000  ? 42  VAL A HG21 1 
ATOM   605  H HG22 . VAL A 1 42  ? 10.66100  -17.53200 2.41700   1.000 51.16000  ? 42  VAL A HG22 1 
ATOM   606  H HG23 . VAL A 1 42  ? 9.38200   -16.92700 1.69500   1.000 51.16000  ? 42  VAL A HG23 1 
ATOM   607  N N    . PRO A 1 43  ? 13.25600  -13.48600 1.79000   1.000 55.18000  ? 43  PRO A N    1 
ATOM   608  C CA   . PRO A 1 43  ? 13.93700  -12.37300 1.11400   1.000 55.58000  ? 43  PRO A CA   1 
ATOM   609  C C    . PRO A 1 43  ? 13.95300  -12.58700 -0.39300  1.000 55.16000  ? 43  PRO A C    1 
ATOM   610  O O    . PRO A 1 43  ? 14.03500  -13.71500 -0.88100  1.000 55.52000  ? 43  PRO A O    1 
ATOM   611  C CB   . PRO A 1 43  ? 15.35300  -12.39900 1.70600   1.000 57.02000  ? 43  PRO A CB   1 
ATOM   612  C CG   . PRO A 1 43  ? 15.21800  -13.14600 3.01800   1.000 57.08000  ? 43  PRO A CG   1 
ATOM   613  C CD   . PRO A 1 43  ? 14.12700  -14.15600 2.77700   1.000 55.96000  ? 43  PRO A CD   1 
ATOM   614  H HA   . PRO A 1 43  ? 13.50800  -11.52800 1.32300   1.000 58.14000  ? 43  PRO A HA   1 
ATOM   615  H HB2  . PRO A 1 43  ? 15.95100  -12.86900 1.10400   1.000 62.03000  ? 43  PRO A HB2  1 
ATOM   616  H HB3  . PRO A 1 43  ? 15.66100  -11.49200 1.85800   1.000 62.03000  ? 43  PRO A HB3  1 
ATOM   617  H HG2  . PRO A 1 43  ? 16.05500  -13.58800 3.23100   1.000 59.66000  ? 43  PRO A HG2  1 
ATOM   618  H HG3  . PRO A 1 43  ? 14.96500  -12.52900 3.72200   1.000 59.66000  ? 43  PRO A HG3  1 
ATOM   619  H HD2  . PRO A 1 43  ? 14.49600  -14.97200 2.40500   1.000 62.19000  ? 43  PRO A HD2  1 
ATOM   620  H HD3  . PRO A 1 43  ? 13.64300  -14.32500 3.60000   1.000 62.19000  ? 43  PRO A HD3  1 
ATOM   621  N N    . ILE A 1 44  ? 13.86400  -11.48300 -1.13600  1.000 56.88000  ? 44  ILE A N    1 
ATOM   622  C CA   . ILE A 1 44  ? 13.84200  -11.57600 -2.59200  1.000 56.76000  ? 44  ILE A CA   1 
ATOM   623  C C    . ILE A 1 44  ? 15.17800  -12.05800 -3.14500  1.000 57.30000  ? 44  ILE A C    1 
ATOM   624  O O    . ILE A 1 44  ? 15.23700  -12.53900 -4.28300  1.000 56.93000  ? 44  ILE A O    1 
ATOM   625  C CB   . ILE A 1 44  ? 13.44300  -10.21700 -3.19700  1.000 56.82000  ? 44  ILE A CB   1 
ATOM   626  C CG1  . ILE A 1 44  ? 13.50000  -10.27500 -4.72500  1.000 56.54000  ? 44  ILE A CG1  1 
ATOM   627  C CG2  . ILE A 1 44  ? 14.33800  -9.11700  -2.64300  1.000 58.89000  ? 44  ILE A CG2  1 
ATOM   628  C CD1  . ILE A 1 44  ? 12.48200  -9.38100  -5.40700  1.000 56.90000  ? 44  ILE A CD1  1 
ATOM   629  H H    . ILE A 1 44  ? 13.81000  -10.68700 -0.81900  1.000 58.91000  ? 44  ILE A H    1 
ATOM   630  H HA   . ILE A 1 44  ? 13.16700  -12.22200 -2.85100  1.000 60.82000  ? 44  ILE A HA   1 
ATOM   631  H HB   . ILE A 1 44  ? 12.52900  -10.02500 -2.93500  1.000 62.18000  ? 44  ILE A HB   1 
ATOM   632  H HG12 . ILE A 1 44  ? 14.38300  -9.99800  -5.01700  1.000 61.85000  ? 44  ILE A HG12 1 
ATOM   633  H HG13 . ILE A 1 44  ? 13.32900  -11.18600 -5.01100  1.000 61.85000  ? 44  ILE A HG13 1 
ATOM   634  H HG21 . ILE A 1 44  ? 14.20900  -8.31500  -3.17300  1.000 75.46000  ? 44  ILE A HG21 1 
ATOM   635  H HG22 . ILE A 1 44  ? 14.10300  -8.94000  -1.72200  1.000 75.46000  ? 44  ILE A HG22 1 
ATOM   636  H HG23 . ILE A 1 44  ? 15.26400  -9.40100  -2.70000  1.000 75.46000  ? 44  ILE A HG23 1 
ATOM   637  H HD11 . ILE A 1 44  ? 12.57800  -9.47000  -6.36800  1.000 73.45000  ? 44  ILE A HD11 1 
ATOM   638  H HD12 . ILE A 1 44  ? 11.59100  -9.65400  -5.13600  1.000 73.45000  ? 44  ILE A HD12 1 
ATOM   639  H HD13 . ILE A 1 44  ? 12.64200  -8.46200  -5.14200  1.000 73.45000  ? 44  ILE A HD13 1 
ATOM   640  N N    . LYS A 1 45  ? 16.25600  -11.95900 -2.36500  1.000 56.88000  ? 45  LYS A N    1 
ATOM   641  C CA   . LYS A 1 45  ? 17.54300  -12.47500 -2.82200  1.000 57.33000  ? 45  LYS A CA   1 
ATOM   642  C C    . LYS A 1 45  ? 17.55400  -13.99500 -2.86700  1.000 56.49000  ? 45  LYS A C    1 
ATOM   643  O O    . LYS A 1 45  ? 18.29000  -14.58400 -3.66600  1.000 56.86000  ? 45  LYS A O    1 
ATOM   644  C CB   . LYS A 1 45  ? 18.66600  -11.95700 -1.92100  1.000 60.42000  ? 45  LYS A CB   1 
ATOM   645  C CG   . LYS A 1 45  ? 19.45900  -10.80800 -2.53100  1.000 64.18000  ? 45  LYS A CG   1 
ATOM   646  C CD   . LYS A 1 45  ? 18.53200  -9.72100  -3.05800  1.000 63.64000  ? 45  LYS A CD   1 
ATOM   647  C CE   . LYS A 1 45  ? 19.22100  -8.83100  -4.08900  1.000 66.35000  ? 45  LYS A CE   1 
ATOM   648  N NZ   . LYS A 1 45  ? 20.29600  -7.96400  -3.52300  1.000 70.41000  ? 45  LYS A NZ   1 
ATOM   649  H H    . LYS A 1 45  ? 16.26700  -11.60400 -1.58200  1.000 62.91000  ? 45  LYS A H    1 
ATOM   650  H HA   . LYS A 1 45  ? 17.70800  -12.16900 -3.72700  1.000 60.06000  ? 45  LYS A HA   1 
ATOM   651  H HB2  . LYS A 1 45  ? 18.28300  -11.64300 -1.08700  1.000 70.14000  ? 45  LYS A HB2  1 
ATOM   652  H HB3  . LYS A 1 45  ? 19.28500  -12.68300 -1.74500  1.000 70.14000  ? 45  LYS A HB3  1 
ATOM   653  H HG2  . LYS A 1 45  ? 20.03200  -10.41800 -1.85300  1.000 84.71000  ? 45  LYS A HG2  1 
ATOM   654  H HG3  . LYS A 1 45  ? 19.99000  -11.14200 -3.27100  1.000 84.71000  ? 45  LYS A HG3  1 
ATOM   655  H HD2  . LYS A 1 45  ? 17.74900  -10.09300 -3.48500  1.000 87.86000  ? 45  LYS A HD2  1 
ATOM   656  H HD3  . LYS A 1 45  ? 18.26200  -9.15700  -2.31600  1.000 87.86000  ? 45  LYS A HD3  1 
ATOM   657  H HE2  . LYS A 1 45  ? 19.62300  -9.39400  -4.76900  1.000 93.89000  ? 45  LYS A HE2  1 
ATOM   658  H HE3  . LYS A 1 45  ? 18.55700  -8.25200  -4.49400  1.000 93.89000  ? 45  LYS A HE3  1 
ATOM   659  H HZ1  . LYS A 1 45  ? 20.65900  -7.47000  -4.16800  1.000 97.02000  ? 45  LYS A HZ1  1 
ATOM   660  H HZ2  . LYS A 1 45  ? 19.95600  -7.42400  -2.90200  1.000 97.02000  ? 45  LYS A HZ2  1 
ATOM   661  H HZ3  . LYS A 1 45  ? 20.92900  -8.46800  -3.15300  1.000 97.02000  ? 45  LYS A HZ3  1 
ATOM   662  N N    . GLN A 1 46  ? 16.74500  -14.64300 -2.03500  1.000 52.32000  ? 46  GLN A N    1 
ATOM   663  C CA   . GLN A 1 46  ? 16.68100  -16.09600 -1.97800  1.000 51.48000  ? 46  GLN A CA   1 
ATOM   664  C C    . GLN A 1 46  ? 15.59500  -16.67300 -2.87900  1.000 50.38000  ? 46  GLN A C    1 
ATOM   665  O O    . GLN A 1 46  ? 15.40500  -17.89400 -2.89400  1.000 49.44000  ? 46  GLN A O    1 
ATOM   666  C CB   . GLN A 1 46  ? 16.45100  -16.54500 -0.53100  1.000 52.12000  ? 46  GLN A CB   1 
ATOM   667  C CG   . GLN A 1 46  ? 17.36100  -15.84500 0.47200   1.000 53.28000  ? 46  GLN A CG   1 
ATOM   668  C CD   . GLN A 1 46  ? 17.18000  -16.34900 1.89300   1.000 54.49000  ? 46  GLN A CD   1 
ATOM   669  O OE1  . GLN A 1 46  ? 16.52300  -17.36400 2.12700   1.000 53.61000  ? 46  GLN A OE1  1 
ATOM   670  N NE2  . GLN A 1 46  ? 17.76500  -15.63800 2.85100   1.000 57.10000  ? 46  GLN A NE2  1 
ATOM   671  H H    . GLN A 1 46  ? 16.21300  -14.25400 -1.48200  1.000 57.31000  ? 46  GLN A H    1 
ATOM   672  H HA   . GLN A 1 46  ? 17.53200  -16.45900 -2.26900  1.000 54.09000  ? 46  GLN A HA   1 
ATOM   673  H HB2  . GLN A 1 46  ? 15.53300  -16.35300 -0.28500  1.000 60.01000  ? 46  GLN A HB2  1 
ATOM   674  H HB3  . GLN A 1 46  ? 16.61600  -17.49900 -0.46800  1.000 60.01000  ? 46  GLN A HB3  1 
ATOM   675  H HG2  . GLN A 1 46  ? 18.28500  -15.99400 0.21700   1.000 61.05000  ? 46  GLN A HG2  1 
ATOM   676  H HG3  . GLN A 1 46  ? 17.16600  -14.89500 0.46800   1.000 61.05000  ? 46  GLN A HG3  1 
ATOM   677  H HE21 . GLN A 1 46  ? 18.21600  -14.93400 2.64900   1.000 83.36000  ? 46  GLN A HE21 1 
ATOM   678  H HE22 . GLN A 1 46  ? 17.69200  -15.88200 3.67300   1.000 83.36000  ? 46  GLN A HE22 1 
ATOM   679  N N    . ILE A 1 47  ? 14.89000  -15.83000 -3.63000  1.000 49.90000  ? 47  ILE A N    1 
ATOM   680  C CA   . ILE A 1 47  ? 13.83200  -16.26000 -4.53600  1.000 48.51000  ? 47  ILE A CA   1 
ATOM   681  C C    . ILE A 1 47  ? 14.35500  -16.19400 -5.96200  1.000 48.00000  ? 47  ILE A C    1 
ATOM   682  O O    . ILE A 1 47  ? 15.00900  -15.21800 -6.35100  1.000 48.75000  ? 47  ILE A O    1 
ATOM   683  C CB   . ILE A 1 47  ? 12.57300  -15.38700 -4.37000  1.000 48.58000  ? 47  ILE A CB   1 
ATOM   684  C CG1  . ILE A 1 47  ? 12.03700  -15.49800 -2.94100  1.000 48.83000  ? 47  ILE A CG1  1 
ATOM   685  C CG2  . ILE A 1 47  ? 11.51600  -15.78600 -5.38900  1.000 46.90000  ? 47  ILE A CG2  1 
ATOM   686  C CD1  . ILE A 1 47  ? 10.98300  -14.46400 -2.59700  1.000 48.98000  ? 47  ILE A CD1  1 
ATOM   687  H H    . ILE A 1 47  ? 15.01000  -14.97900 -3.63200  1.000 53.15000  ? 47  ILE A H    1 
ATOM   688  H HA   . ILE A 1 47  ? 13.59200  -17.17900 -4.34100  1.000 49.81000  ? 47  ILE A HA   1 
ATOM   689  H HB   . ILE A 1 47  ? 12.81900  -14.46300 -4.53200  1.000 53.00000  ? 47  ILE A HB   1 
ATOM   690  H HG12 . ILE A 1 47  ? 11.64000  -16.37500 -2.82500  1.000 52.83000  ? 47  ILE A HG12 1 
ATOM   691  H HG13 . ILE A 1 47  ? 12.77200  -15.38600 -2.31800  1.000 52.83000  ? 47  ILE A HG13 1 
ATOM   692  H HG21 . ILE A 1 47  ? 10.67200  -15.37300 -5.15000  1.000 45.77000  ? 47  ILE A HG21 1 
ATOM   693  H HG22 . ILE A 1 47  ? 11.79100  -15.48300 -6.26900  1.000 45.77000  ? 47  ILE A HG22 1 
ATOM   694  H HG23 . ILE A 1 47  ? 11.42300  -16.75100 -5.38400  1.000 45.77000  ? 47  ILE A HG23 1 
ATOM   695  H HD11 . ILE A 1 47  ? 10.83600  -14.47000 -1.63900  1.000 55.53000  ? 47  ILE A HD11 1 
ATOM   696  H HD12 . ILE A 1 47  ? 11.29600  -13.59000 -2.87800  1.000 55.53000  ? 47  ILE A HD12 1 
ATOM   697  H HD13 . ILE A 1 47  ? 10.16000  -14.68500 -3.06000  1.000 55.53000  ? 47  ILE A HD13 1 
ATOM   698  N N    . GLN A 1 48  ? 14.07100  -17.23300 -6.74300  1.000 40.09000  ? 48  GLN A N    1 
ATOM   699  C CA   . GLN A 1 48  ? 14.43900  -17.27100 -8.15500  1.000 39.71000  ? 48  GLN A CA   1 
ATOM   700  C C    . GLN A 1 48  ? 13.31000  -16.63800 -8.96200  1.000 38.50000  ? 48  GLN A C    1 
ATOM   701  O O    . GLN A 1 48  ? 12.21300  -17.19800 -9.05400  1.000 37.32000  ? 48  GLN A O    1 
ATOM   702  C CB   . GLN A 1 48  ? 14.70700  -18.70400 -8.60500  1.000 38.55000  ? 48  GLN A CB   1 
ATOM   703  C CG   . GLN A 1 48  ? 15.95800  -19.30900 -7.99700  1.000 38.61000  ? 48  GLN A CG   1 
ATOM   704  C CD   . GLN A 1 48  ? 16.15000  -20.76000 -8.38600  1.000 38.59000  ? 48  GLN A CD   1 
ATOM   705  O OE1  . GLN A 1 48  ? 15.93900  -21.66300 -7.57600  1.000 39.25000  ? 48  GLN A OE1  1 
ATOM   706  N NE2  . GLN A 1 48  ? 16.55400  -20.99300 -9.62900  1.000 38.95000  ? 48  GLN A NE2  1 
ATOM   707  H H    . GLN A 1 48  ? 13.65900  -17.93900 -6.47400  1.000 46.27000  ? 48  GLN A H    1 
ATOM   708  H HA   . GLN A 1 48  ? 15.24500  -16.75000 -8.29400  1.000 48.82000  ? 48  GLN A HA   1 
ATOM   709  H HB2  . GLN A 1 48  ? 13.95600  -19.25800 -8.34500  1.000 43.22000  ? 48  GLN A HB2  1 
ATOM   710  H HB3  . GLN A 1 48  ? 14.80800  -18.71700 -9.57000  1.000 43.22000  ? 48  GLN A HB3  1 
ATOM   711  H HG2  . GLN A 1 48  ? 16.73200  -18.81100 -8.30300  1.000 32.47000  ? 48  GLN A HG2  1 
ATOM   712  H HG3  . GLN A 1 48  ? 15.89400  -19.26300 -7.03000  1.000 32.47000  ? 48  GLN A HG3  1 
ATOM   713  H HE21 . GLN A 1 48  ? 16.69200  -20.33600 -10.16700 1.000 46.43000  ? 48  GLN A HE21 1 
ATOM   714  H HE22 . GLN A 1 48  ? 16.67700  -21.80100 -9.89700  1.000 46.43000  ? 48  GLN A HE22 1 
ATOM   715  N N    . VAL A 1 49  ? 13.57900  -15.47200 -9.54500  1.000 36.50000  ? 49  VAL A N    1 
ATOM   716  C CA   . VAL A 1 49  ? 12.57200  -14.68700 -10.24700 1.000 35.96000  ? 49  VAL A CA   1 
ATOM   717  C C    . VAL A 1 49  ? 12.83200  -14.77000 -11.74300 1.000 35.19000  ? 49  VAL A C    1 
ATOM   718  O O    . VAL A 1 49  ? 13.98300  -14.70000 -12.19000 1.000 36.41000  ? 49  VAL A O    1 
ATOM   719  C CB   . VAL A 1 49  ? 12.57700  -13.21900 -9.77800  1.000 37.43000  ? 49  VAL A CB   1 
ATOM   720  C CG1  . VAL A 1 49  ? 11.47200  -12.43600 -10.47300 1.000 36.76000  ? 49  VAL A CG1  1 
ATOM   721  C CG2  . VAL A 1 49  ? 12.43100  -13.14000 -8.26400  1.000 37.89000  ? 49  VAL A CG2  1 
ATOM   722  H H    . VAL A 1 49  ? 14.35800  -15.10800 -9.54600  1.000 44.79000  ? 49  VAL A H    1 
ATOM   723  H HA   . VAL A 1 49  ? 11.69300  -15.05800 -10.07000 1.000 45.44000  ? 49  VAL A HA   1 
ATOM   724  H HB   . VAL A 1 49  ? 13.42600  -12.81500 -10.01800 1.000 48.76000  ? 49  VAL A HB   1 
ATOM   725  H HG11 . VAL A 1 49  ? 11.39600  -11.56300 -10.05700 1.000 47.25000  ? 49  VAL A HG11 1 
ATOM   726  H HG12 . VAL A 1 49  ? 11.69500  -12.33500 -11.41200 1.000 47.25000  ? 49  VAL A HG12 1 
ATOM   727  H HG13 . VAL A 1 49  ? 10.63600  -12.92000 -10.38000 1.000 47.25000  ? 49  VAL A HG13 1 
ATOM   728  H HG21 . VAL A 1 49  ? 12.22900  -12.22500 -8.01200  1.000 45.25000  ? 49  VAL A HG21 1 
ATOM   729  H HG22 . VAL A 1 49  ? 11.71200  -13.72800 -7.98600  1.000 45.25000  ? 49  VAL A HG22 1 
ATOM   730  H HG23 . VAL A 1 49  ? 13.26300  -13.42100 -7.85300  1.000 45.25000  ? 49  VAL A HG23 1 
ATOM   731  N N    . HIS A 1 50  ? 11.78200  -14.92400 -12.54100 1.000 56.01000  ? 50  HIS A N    1 
ATOM   732  C CA   . HIS A 1 50  ? 11.88800  -14.95600 -14.02300 1.000 55.09000  ? 50  HIS A CA   1 
ATOM   733  C C    . HIS A 1 50  ? 10.74100  -14.12700 -14.58500 1.000 54.67000  ? 50  HIS A C    1 
ATOM   734  O O    . HIS A 1 50  ? 9.59900   -14.59700 -14.60300 1.000 54.17000  ? 50  HIS A O    1 
ATOM   735  C CB   . HIS A 1 50  ? 11.88000  -16.39000 -14.54800 1.000 54.03000  ? 50  HIS A CB   1 
ATOM   736  C CG   . HIS A 1 50  ? 12.47600  -17.37800 -13.60400 1.000 55.29000  ? 50  HIS A CG   1 
ATOM   737  N ND1  . HIS A 1 50  ? 11.75300  -17.98800 -12.60300 1.000 55.04000  ? 50  HIS A ND1  1 
ATOM   738  C CD2  . HIS A 1 50  ? 13.71900  -17.85000 -13.50400 1.000 56.25000  ? 50  HIS A CD2  1 
ATOM   739  C CE1  . HIS A 1 50  ? 12.54400  -18.80600 -11.93200 1.000 55.44000  ? 50  HIS A CE1  1 
ATOM   740  N NE2  . HIS A 1 50  ? 13.74500  -18.73500 -12.46100 1.000 56.18000  ? 50  HIS A NE2  1 
ATOM   741  H H    . HIS A 1 50  ? 10.97600  -15.01500 -12.25500 1.000 53.53000  ? 50  HIS A H    1 
ATOM   742  H HA   . HIS A 1 50  ? 12.72200  -14.54000 -14.29300 1.000 51.03000  ? 50  HIS A HA   1 
ATOM   743  H HB2  . HIS A 1 50  ? 10.96300  -16.65700 -14.71600 1.000 51.14000  ? 50  HIS A HB2  1 
ATOM   744  H HB3  . HIS A 1 50  ? 12.38900  -16.42400 -15.37300 1.000 51.14000  ? 50  HIS A HB3  1 
ATOM   745  H HD2  . HIS A 1 50  ? 14.43900  -17.62000 -14.04600 1.000 67.08000  ? 50  HIS A HD2  1 
ATOM   746  H HE1  . HIS A 1 50  ? 12.29600  -19.33500 -11.20900 1.000 66.87000  ? 50  HIS A HE1  1 
ATOM   747  H HE2  . HIS A 1 50  ? 14.43400  -19.17600 -12.19700 1.000 67.04000  ? 50  HIS A HE2  1 
ATOM   748  N N    . LYS A 1 51  ? 11.03900  -12.91300 -15.01700 1.000 40.34000  ? 51  LYS A N    1 
ATOM   749  C CA   . LYS A 1 51  ? 10.00400  -12.02700 -15.58600 1.000 40.60000  ? 51  LYS A CA   1 
ATOM   750  C C    . LYS A 1 51  ? 10.08300  -12.10400 -17.11000 1.000 40.25000  ? 51  LYS A C    1 
ATOM   751  O O    . LYS A 1 51  ? 11.12100  -11.71600 -17.65300 1.000 41.50000  ? 51  LYS A O    1 
ATOM   752  C CB   . LYS A 1 51  ? 10.19100  -10.60300 -15.05800 1.000 42.30000  ? 51  LYS A CB   1 
ATOM   753  C CG   . LYS A 1 51  ? 9.86400   -10.40200 -13.59300 1.000 42.86000  ? 51  LYS A CG   1 
ATOM   754  C CD   . LYS A 1 51  ? 10.64900  -9.26200  -12.95800 1.000 43.90000  ? 51  LYS A CD   1 
ATOM   755  C CE   . LYS A 1 51  ? 9.76700   -8.29400  -12.24500 1.000 44.45000  ? 51  LYS A CE   1 
ATOM   756  N NZ   . LYS A 1 51  ? 10.44300  -7.71700  -11.08400 1.000 45.69000  ? 51  LYS A NZ   1 
ATOM   757  H H    . LYS A 1 51  ? 11.82700  -12.56800 -14.99700 1.000 43.03000  ? 51  LYS A H    1 
ATOM   758  H HA   . LYS A 1 51  ? 9.12700   -12.33800 -15.31200 1.000 49.20000  ? 51  LYS A HA   1 
ATOM   759  H HB2  . LYS A 1 51  ? 11.11800  -10.35100 -15.18900 1.000 53.80000  ? 51  LYS A HB2  1 
ATOM   760  H HB3  . LYS A 1 51  ? 9.61900   -10.00900 -15.56800 1.000 53.80000  ? 51  LYS A HB3  1 
ATOM   761  H HG2  . LYS A 1 51  ? 8.91800   -10.20600 -13.51100 1.000 53.45000  ? 51  LYS A HG2  1 
ATOM   762  H HG3  . LYS A 1 51  ? 10.07600  -11.21600 -13.10900 1.000 53.45000  ? 51  LYS A HG3  1 
ATOM   763  H HD2  . LYS A 1 51  ? 11.27500  -9.62900  -12.31500 1.000 50.32000  ? 51  LYS A HD2  1 
ATOM   764  H HD3  . LYS A 1 51  ? 11.12700  -8.77700  -13.64900 1.000 50.32000  ? 51  LYS A HD3  1 
ATOM   765  H HE2  . LYS A 1 51  ? 9.52800   -7.57300  -12.84800 1.000 52.05000  ? 51  LYS A HE2  1 
ATOM   766  H HE3  . LYS A 1 51  ? 8.97000   -8.74800  -11.93000 1.000 52.05000  ? 51  LYS A HE3  1 
ATOM   767  H HZ1  . LYS A 1 51  ? 9.90200   -7.14300  -10.67200 1.000 56.03000  ? 51  LYS A HZ1  1 
ATOM   768  H HZ2  . LYS A 1 51  ? 10.67000  -8.36100  -10.51300 1.000 56.03000  ? 51  LYS A HZ2  1 
ATOM   769  H HZ3  . LYS A 1 51  ? 11.17800  -7.28700  -11.34300 1.000 56.03000  ? 51  LYS A HZ3  1 
ATOM   770  N N    . SER A 1 52  ? 9.03400   -12.60600 -17.75500 1.000 50.70000  ? 52  SER A N    1 
ATOM   771  C CA   . SER A 1 52  ? 8.93200   -12.66300 -19.23200 1.000 49.93000  ? 52  SER A CA   1 
ATOM   772  C C    . SER A 1 52  ? 7.77400   -11.75200 -19.62500 1.000 49.90000  ? 52  SER A C    1 
ATOM   773  O O    . SER A 1 52  ? 6.66100   -12.23900 -19.71200 1.000 49.46000  ? 52  SER A O    1 
ATOM   774  C CB   . SER A 1 52  ? 8.70400   -14.05100 -19.70500 1.000 48.79000  ? 52  SER A CB   1 
ATOM   775  O OG   . SER A 1 52  ? 9.86700   -14.84000 -19.51900 1.000 51.83000  ? 52  SER A OG   1 
ATOM   776  H H    . SER A 1 52  ? 8.34500   -12.93100 -17.35700 1.000 55.35000  ? 52  SER A H    1 
ATOM   777  H HA   . SER A 1 52  ? 9.74800   -12.32500 -19.63300 1.000 49.60000  ? 52  SER A HA   1 
ATOM   778  H HB2  . SER A 1 52  ? 7.97300   -14.44100 -19.20100 1.000 48.19000  ? 52  SER A HB2  1 
ATOM   779  H HB3  . SER A 1 52  ? 8.48300   -14.03100 -20.64900 1.000 48.19000  ? 52  SER A HB3  1 
ATOM   780  H HG   . SER A 1 52  ? 9.72900   -15.62300 -19.78900 1.000 75.33000  ? 52  SER A HG   1 
ATOM   781  N N    . GLY A 1 53  ? 8.05100   -10.49100 -19.90000 1.000 46.83000  ? 53  GLY A N    1 
ATOM   782  C CA   . GLY A 1 53  ? 6.98700   -9.52600  -20.20100 1.000 47.41000  ? 53  GLY A CA   1 
ATOM   783  C C    . GLY A 1 53  ? 6.08100   -9.32300  -19.01400 1.000 46.92000  ? 53  GLY A C    1 
ATOM   784  O O    . GLY A 1 53  ? 6.58700   -8.82700  -18.00500 1.000 48.05000  ? 53  GLY A O    1 
ATOM   785  H H    . GLY A 1 53  ? 8.84400   -10.16000 -19.92100 1.000 49.42000  ? 53  GLY A H    1 
ATOM   786  H HA2  . GLY A 1 53  ? 7.37900   -8.67200  -20.44300 1.000 53.54000  ? 53  GLY A HA2  1 
ATOM   787  H HA3  . GLY A 1 53  ? 6.45600   -9.84700  -20.94600 1.000 53.54000  ? 53  GLY A HA3  1 
ATOM   788  N N    . GLU A 1 54  ? 4.79200   -9.62300  -19.16100 1.000 44.16000  ? 54  GLU A N    1 
ATOM   789  C CA   . GLU A 1 54  ? 3.78500   -9.46100  -18.09100 1.000 44.59000  ? 54  GLU A CA   1 
ATOM   790  C C    . GLU A 1 54  ? 3.57700   -10.78800 -17.34600 1.000 43.26000  ? 54  GLU A C    1 
ATOM   791  O O    . GLU A 1 54  ? 2.63600   -10.86200 -16.55700 1.000 43.49000  ? 54  GLU A O    1 
ATOM   792  C CB   . GLU A 1 54  ? 2.54300   -8.91900  -18.79500 1.000 45.26000  ? 54  GLU A CB   1 
ATOM   793  C CG   . GLU A 1 54  ? 2.52300   -7.39800  -18.88900 1.000 47.21000  ? 54  GLU A CG   1 
ATOM   794  C CD   . GLU A 1 54  ? 2.09500   -6.70000  -17.61200 1.000 48.22000  ? 54  GLU A CD   1 
ATOM   795  O OE1  . GLU A 1 54  ? 2.12200   -7.34100  -16.54500 1.000 47.51000  ? 54  GLU A OE1  1 
ATOM   796  O OE2  . GLU A 1 54  ? 1.75200   -5.50400  -17.68600 1.000 49.17000  ? 54  GLU A OE2  1 
ATOM   797  H H    . GLU A 1 54  ? 4.46100   -9.93400  -19.89100 1.000 46.92000  ? 54  GLU A H    1 
ATOM   798  H HA   . GLU A 1 54  ? 4.09200   -8.79700  -17.45500 1.000 49.80000  ? 54  GLU A HA   1 
ATOM   799  H HB2  . GLU A 1 54  ? 2.49400   -9.28200  -19.69300 1.000 52.39000  ? 54  GLU A HB2  1 
ATOM   800  H HB3  . GLU A 1 54  ? 1.76700   -9.18300  -18.28300 1.000 52.39000  ? 54  GLU A HB3  1 
ATOM   801  H HG2  . GLU A 1 54  ? 3.41500   -7.08800  -19.11000 1.000 59.35000  ? 54  GLU A HG2  1 
ATOM   802  H HG3  . GLU A 1 54  ? 1.90400   -7.13800  -19.58900 1.000 59.35000  ? 54  GLU A HG3  1 
ATOM   803  N N    . PHE A 1 55  ? 4.37700   -11.81200 -17.61700 1.000 37.10000  ? 55  PHE A N    1 
ATOM   804  C CA   . PHE A 1 55  ? 4.32500   -13.07300 -16.88800 1.000 36.05000  ? 55  PHE A CA   1 
ATOM   805  C C    . PHE A 1 55  ? 5.48200   -13.09300 -15.89500 1.000 36.89000  ? 55  PHE A C    1 
ATOM   806  O O    . PHE A 1 55  ? 6.64700   -13.00700 -16.29800 1.000 37.59000  ? 55  PHE A O    1 
ATOM   807  C CB   . PHE A 1 55  ? 4.41400   -14.25700 -17.85200 1.000 34.18000  ? 55  PHE A CB   1 
ATOM   808  C CG   . PHE A 1 55  ? 4.16300   -15.59000 -17.20500 1.000 33.32000  ? 55  PHE A CG   1 
ATOM   809  C CD1  . PHE A 1 55  ? 5.17100   -16.24100 -16.51300 1.000 33.96000  ? 55  PHE A CD1  1 
ATOM   810  C CD2  . PHE A 1 55  ? 2.92100   -16.19600 -17.29200 1.000 32.28000  ? 55  PHE A CD2  1 
ATOM   811  C CE1  . PHE A 1 55  ? 4.94300   -17.46600 -15.91600 1.000 32.84000  ? 55  PHE A CE1  1 
ATOM   812  C CE2  . PHE A 1 55  ? 2.68800   -17.42200 -16.69900 1.000 31.10000  ? 55  PHE A CE2  1 
ATOM   813  C CZ   . PHE A 1 55  ? 3.70000   -18.05700 -16.01000 1.000 31.52000  ? 55  PHE A CZ   1 
ATOM   814  H H    . PHE A 1 55  ? 4.97500   -11.80200 -18.23500 1.000 46.11000  ? 55  PHE A H    1 
ATOM   815  H HA   . PHE A 1 55  ? 3.49100   -13.13500 -16.39600 1.000 45.74000  ? 55  PHE A HA   1 
ATOM   816  H HB2  . PHE A 1 55  ? 3.75400   -14.13900 -18.55300 1.000 38.89000  ? 55  PHE A HB2  1 
ATOM   817  H HB3  . PHE A 1 55  ? 5.30300   -14.27800 -18.23900 1.000 38.89000  ? 55  PHE A HB3  1 
ATOM   818  H HD1  . PHE A 1 55  ? 6.01000   -15.84600 -16.44500 1.000 47.55000  ? 55  PHE A HD1  1 
ATOM   819  H HD2  . PHE A 1 55  ? 2.23500   -15.77200 -17.75400 1.000 41.03000  ? 55  PHE A HD2  1 
ATOM   820  H HE1  . PHE A 1 55  ? 5.62800   -17.89300 -15.45300 1.000 42.93000  ? 55  PHE A HE1  1 
ATOM   821  H HE2  . PHE A 1 55  ? 1.84900   -17.81800 -16.76300 1.000 36.99000  ? 55  PHE A HE2  1 
ATOM   822  H HZ   . PHE A 1 55  ? 3.54500   -18.88200 -15.61000 1.000 39.08000  ? 55  PHE A HZ   1 
ATOM   823  N N    . CYS A 1 56  ? 5.16500   -13.19100 -14.60400 1.000 31.61000  ? 56  CYS A N    1 
ATOM   824  C CA   . CYS A 1 56  ? 6.17200   -13.24500 -13.55300 1.000 32.50000  ? 56  CYS A CA   1 
ATOM   825  C C    . CYS A 1 56  ? 6.08500   -14.57800 -12.82500 1.000 31.45000  ? 56  CYS A C    1 
ATOM   826  O O    . CYS A 1 56  ? 4.99100   -15.05700 -12.51200 1.000 30.78000  ? 56  CYS A O    1 
ATOM   827  C CB   . CYS A 1 56  ? 6.00700   -12.10000 -12.55200 1.000 34.24000  ? 56  CYS A CB   1 
ATOM   828  S SG   . CYS A 1 56  ? 7.35600   -11.98300 -11.35100 1.000 35.71000  ? 56  CYS A SG   1 
ATOM   829  H H    . CYS A 1 56  ? 4.35800   -13.22800 -14.31000 1.000 44.97000  ? 56  CYS A H    1 
ATOM   830  H HA   . CYS A 1 56  ? 7.05500   -13.17400 -13.94800 1.000 43.53000  ? 56  CYS A HA   1 
ATOM   831  H HB2  . CYS A 1 56  ? 5.97000   -11.26200 -13.03900 1.000 45.22000  ? 56  CYS A HB2  1 
ATOM   832  H HB3  . CYS A 1 56  ? 5.18200   -12.23100 -12.06000 1.000 45.22000  ? 56  CYS A HB3  1 
ATOM   833  H HG   . CYS A 1 56  ? 7.24700   -10.99900 -10.67700 1.000 46.45000  ? 56  CYS A HG   1 
ATOM   834  N N    . ARG A 1 57  ? 7.24800   -15.16200 -12.54400 1.000 46.72000  ? 57  ARG A N    1 
ATOM   835  C CA   . ARG A 1 57  ? 7.35700   -16.50800 -11.99700 1.000 45.81000  ? 57  ARG A CA   1 
ATOM   836  C C    . ARG A 1 57  ? 8.33600   -16.47400 -10.83600 1.000 47.19000  ? 57  ARG A C    1 
ATOM   837  O O    . ARG A 1 57  ? 9.47400   -16.01900 -10.99500 1.000 48.22000  ? 57  ARG A O    1 
ATOM   838  C CB   . ARG A 1 57  ? 7.82400   -17.48800 -13.07600 1.000 45.22000  ? 57  ARG A CB   1 
ATOM   839  C CG   . ARG A 1 57  ? 8.06400   -18.91400 -12.61600 1.000 45.43000  ? 57  ARG A CG   1 
ATOM   840  C CD   . ARG A 1 57  ? 8.95000   -19.63200 -13.63200 1.000 45.15000  ? 57  ARG A CD   1 
ATOM   841  N NE   . ARG A 1 57  ? 9.17200   -21.03300 -13.29700 1.000 45.88000  ? 57  ARG A NE   1 
ATOM   842  C CZ   . ARG A 1 57  ? 8.67600   -22.05600 -13.97900 1.000 45.86000  ? 57  ARG A CZ   1 
ATOM   843  N NH1  . ARG A 1 57  ? 7.96700   -21.87600 -15.08200 1.000 45.81000  ? 57  ARG A NH1  1 
ATOM   844  N NH2  . ARG A 1 57  ? 8.89600   -23.29300 -13.54300 1.000 46.59000  ? 57  ARG A NH2  1 
ATOM   845  H H    . ARG A 1 57  ? 8.01100   -14.78400 -12.66700 1.000 45.26000  ? 57  ARG A H    1 
ATOM   846  H HA   . ARG A 1 57  ? 6.49300   -16.79900 -11.66600 1.000 41.06000  ? 57  ARG A HA   1 
ATOM   847  H HB2  . ARG A 1 57  ? 7.15000   -17.51800 -13.77300 1.000 47.48000  ? 57  ARG A HB2  1 
ATOM   848  H HB3  . ARG A 1 57  ? 8.65800   -17.15900 -13.44700 1.000 47.48000  ? 57  ARG A HB3  1 
ATOM   849  H HG2  . ARG A 1 57  ? 8.51600   -18.91900 -11.75800 1.000 52.62000  ? 57  ARG A HG2  1 
ATOM   850  H HG3  . ARG A 1 57  ? 7.21700   -19.38300 -12.55900 1.000 52.62000  ? 57  ARG A HG3  1 
ATOM   851  H HD2  . ARG A 1 57  ? 8.54000   -19.56500 -14.50600 1.000 49.99000  ? 57  ARG A HD2  1 
ATOM   852  H HD3  . ARG A 1 57  ? 9.81500   -19.19700 -13.64900 1.000 49.99000  ? 57  ARG A HD3  1 
ATOM   853  H HE   . ARG A 1 57  ? 9.65800   -21.20800 -12.61000 1.000 55.82000  ? 57  ARG A HE   1 
ATOM   854  H HH11 . ARG A 1 57  ? 7.81000   -21.08800 -15.38100 1.000 70.22000  ? 57  ARG A HH11 1 
ATOM   855  H HH12 . ARG A 1 57  ? 7.65900   -22.55900 -15.50400 1.000 70.22000  ? 57  ARG A HH12 1 
ATOM   856  H HH21 . ARG A 1 57  ? 9.35700   -23.42100 -12.82900 1.000 60.04000  ? 57  ARG A HH21 1 
ATOM   857  H HH22 . ARG A 1 57  ? 8.58200   -23.96500 -13.97900 1.000 60.04000  ? 57  ARG A HH22 1 
ATOM   858  N N    . LEU A 1 58  ? 7.89900   -16.95400 -9.67700  1.000 37.05000  ? 58  LEU A N    1 
ATOM   859  C CA   . LEU A 1 58  ? 8.70200   -16.92900 -8.46300  1.000 38.19000  ? 58  LEU A CA   1 
ATOM   860  C C    . LEU A 1 58  ? 8.85200   -18.34900 -7.93700  1.000 37.25000  ? 58  LEU A C    1 
ATOM   861  O O    . LEU A 1 58  ? 7.85500   -18.99600 -7.59800  1.000 37.08000  ? 58  LEU A O    1 
ATOM   862  C CB   . LEU A 1 58  ? 8.05800   -16.03400 -7.40400  1.000 39.11000  ? 58  LEU A CB   1 
ATOM   863  C CG   . LEU A 1 58  ? 7.73500   -14.58500 -7.76900  1.000 39.69000  ? 58  LEU A CG   1 
ATOM   864  C CD1  . LEU A 1 58  ? 6.90500   -13.95600 -6.65600  1.000 40.48000  ? 58  LEU A CD1  1 
ATOM   865  C CD2  . LEU A 1 58  ? 9.00200   -13.79300 -8.00200  1.000 41.25000  ? 58  LEU A CD2  1 
ATOM   866  H H    . LEU A 1 58  ? 7.12300   -17.30700 -9.56800  1.000 45.52000  ? 58  LEU A H    1 
ATOM   867  H HA   . LEU A 1 58  ? 9.58500   -16.58100 -8.66200  1.000 41.63000  ? 58  LEU A HA   1 
ATOM   868  H HB2  . LEU A 1 58  ? 7.22300   -16.44800 -7.13500  1.000 37.84000  ? 58  LEU A HB2  1 
ATOM   869  H HB3  . LEU A 1 58  ? 8.65500   -16.00400 -6.64000  1.000 37.84000  ? 58  LEU A HB3  1 
ATOM   870  H HG   . LEU A 1 58  ? 7.21100   -14.56900 -8.58500  1.000 38.84000  ? 58  LEU A HG   1 
ATOM   871  H HD11 . LEU A 1 58  ? 6.70900   -13.03500 -6.89100  1.000 39.57000  ? 58  LEU A HD11 1 
ATOM   872  H HD12 . LEU A 1 58  ? 6.07900   -14.45600 -6.55700  1.000 39.57000  ? 58  LEU A HD12 1 
ATOM   873  H HD13 . LEU A 1 58  ? 7.41100   -13.98600 -5.82900  1.000 39.57000  ? 58  LEU A HD13 1 
ATOM   874  H HD21 . LEU A 1 58  ? 8.76600   -12.88400 -8.24300  1.000 50.80000  ? 58  LEU A HD21 1 
ATOM   875  H HD22 . LEU A 1 58  ? 9.52800   -13.79300 -7.18700  1.000 50.80000  ? 58  LEU A HD22 1 
ATOM   876  H HD23 . LEU A 1 58  ? 9.50500   -14.20600 -8.72100  1.000 50.80000  ? 58  LEU A HD23 1 
ATOM   877  N N    . ARG A 1 59  ? 10.09200  -18.82700 -7.87200  1.000 31.84000  ? 59  ARG A N    1 
ATOM   878  C CA   . ARG A 1 59  ? 10.41400  -20.13600 -7.31900  1.000 32.44000  ? 59  ARG A CA   1 
ATOM   879  C C    . ARG A 1 59  ? 11.09200  -19.93600 -5.97000  1.000 33.89000  ? 59  ARG A C    1 
ATOM   880  O O    . ARG A 1 59  ? 12.16300  -19.32400 -5.89600  1.000 34.70000  ? 59  ARG A O    1 
ATOM   881  C CB   . ARG A 1 59  ? 11.32200  -20.92500 -8.26200  1.000 31.87000  ? 59  ARG A CB   1 
ATOM   882  C CG   . ARG A 1 59  ? 11.77700  -22.26300 -7.70400  1.000 32.44000  ? 59  ARG A CG   1 
ATOM   883  C CD   . ARG A 1 59  ? 10.63400  -23.26700 -7.63000  1.000 32.52000  ? 59  ARG A CD   1 
ATOM   884  N NE   . ARG A 1 59  ? 10.39800  -23.94200 -8.90200  1.000 32.02000  ? 59  ARG A NE   1 
ATOM   885  C CZ   . ARG A 1 59  ? 9.56200   -24.95800 -9.06400  1.000 31.93000  ? 59  ARG A CZ   1 
ATOM   886  N NH1  . ARG A 1 59  ? 8.86800   -25.45200 -8.05100  1.000 33.14000  ? 59  ARG A NH1  1 
ATOM   887  N NH2  . ARG A 1 59  ? 9.41800   -25.49400 -10.27300 1.000 31.20000  ? 59  ARG A NH2  1 
ATOM   888  H H    . ARG A 1 59  ? 10.78300  -18.39700 -8.15100  1.000 32.45000  ? 59  ARG A H    1 
ATOM   889  H HA   . ARG A 1 59  ? 9.59700   -20.63800 -7.18100  1.000 38.33000  ? 59  ARG A HA   1 
ATOM   890  H HB2  . ARG A 1 59  ? 10.84000  -21.09800 -9.08600  1.000 35.35000  ? 59  ARG A HB2  1 
ATOM   891  H HB3  . ARG A 1 59  ? 12.11200  -20.39700 -8.45000  1.000 35.35000  ? 59  ARG A HB3  1 
ATOM   892  H HG2  . ARG A 1 59  ? 12.45800  -22.63100 -8.28900  1.000 35.40000  ? 59  ARG A HG2  1 
ATOM   893  H HG3  . ARG A 1 59  ? 12.13800  -22.14600 -6.81200  1.000 35.40000  ? 59  ARG A HG3  1 
ATOM   894  H HD2  . ARG A 1 59  ? 10.85200  -23.94300 -6.96900  1.000 40.63000  ? 59  ARG A HD2  1 
ATOM   895  H HD3  . ARG A 1 59  ? 9.81800   -22.81000 -7.37800  1.000 40.63000  ? 59  ARG A HD3  1 
ATOM   896  H HE   . ARG A 1 59  ? 10.82900  -23.66200 -9.59100  1.000 43.13000  ? 59  ARG A HE   1 
ATOM   897  H HH11 . ARG A 1 59  ? 8.95100   -25.11500 -7.26400  1.000 45.16000  ? 59  ARG A HH11 1 
ATOM   898  H HH12 . ARG A 1 59  ? 8.33200   -26.11200 -8.18000  1.000 45.16000  ? 59  ARG A HH12 1 
ATOM   899  H HH21 . ARG A 1 59  ? 9.86400   -25.18100 -10.93800 1.000 36.76000  ? 59  ARG A HH21 1 
ATOM   900  H HH22 . ARG A 1 59  ? 8.87900   -26.15400 -10.38900 1.000 36.76000  ? 59  ARG A HH22 1 
ATOM   901  N N    . PHE A 1 60  ? 10.48300  -20.45900 -4.92100  1.000 33.01000  ? 60  PHE A N    1 
ATOM   902  C CA   . PHE A 1 60  ? 11.02800  -20.25300 -3.58800  1.000 34.44000  ? 60  PHE A CA   1 
ATOM   903  C C    . PHE A 1 60  ? 11.99200  -21.37400 -3.21300  1.000 34.78000  ? 60  PHE A C    1 
ATOM   904  O O    . PHE A 1 60  ? 11.86800  -22.50100 -3.70200  1.000 34.54000  ? 60  PHE A O    1 
ATOM   905  C CB   . PHE A 1 60  ? 9.90100   -20.17900 -2.56400  1.000 34.79000  ? 60  PHE A CB   1 
ATOM   906  C CG   . PHE A 1 60  ? 9.04400   -18.95400 -2.70200  1.000 34.89000  ? 60  PHE A CG   1 
ATOM   907  C CD1  . PHE A 1 60  ? 8.10900   -18.85400 -3.72000  1.000 33.96000  ? 60  PHE A CD1  1 
ATOM   908  C CD2  . PHE A 1 60  ? 9.17800   -17.89700 -1.81800  1.000 36.05000  ? 60  PHE A CD2  1 
ATOM   909  C CE1  . PHE A 1 60  ? 7.32300   -17.72500 -3.85100  1.000 33.64000  ? 60  PHE A CE1  1 
ATOM   910  C CE2  . PHE A 1 60  ? 8.39400   -16.76400 -1.94500  1.000 35.73000  ? 60  PHE A CE2  1 
ATOM   911  C CZ   . PHE A 1 60  ? 7.46600   -16.67900 -2.96300  1.000 34.37000  ? 60  PHE A CZ   1 
ATOM   912  H H    . PHE A 1 60  ? 9.76400   -20.93000 -4.94900  1.000 37.29000  ? 60  PHE A H    1 
ATOM   913  H HA   . PHE A 1 60  ? 11.50700  -19.41000 -3.57300  1.000 41.08000  ? 60  PHE A HA   1 
ATOM   914  H HB2  . PHE A 1 60  ? 9.32900   -20.95500 -2.67300  1.000 43.41000  ? 60  PHE A HB2  1 
ATOM   915  H HB3  . PHE A 1 60  ? 10.28400  -20.17500 -1.67300  1.000 43.41000  ? 60  PHE A HB3  1 
ATOM   916  H HD1  . PHE A 1 60  ? 8.00900   -19.55600 -4.32200  1.000 44.81000  ? 60  PHE A HD1  1 
ATOM   917  H HD2  . PHE A 1 60  ? 9.80300   -17.94900 -1.13100  1.000 50.19000  ? 60  PHE A HD2  1 
ATOM   918  H HE1  . PHE A 1 60  ? 6.69800   -17.67000 -4.53800  1.000 38.91000  ? 60  PHE A HE1  1 
ATOM   919  H HE2  . PHE A 1 60  ? 8.49200   -16.06100 -1.34500  1.000 46.22000  ? 60  PHE A HE2  1 
ATOM   920  H HZ   . PHE A 1 60  ? 6.93700   -15.91900 -3.04900  1.000 36.91000  ? 60  PHE A HZ   1 
ATOM   921  N N    . PRO A 1 61  ? 12.96500  -21.08300 -2.34200  1.000 38.57000  ? 61  PRO A N    1 
ATOM   922  C CA   . PRO A 1 61  ? 13.95900  -22.10400 -1.97400  1.000 39.15000  ? 61  PRO A CA   1 
ATOM   923  C C    . PRO A 1 61  ? 13.42200  -23.18200 -1.04400  1.000 39.33000  ? 61  PRO A C    1 
ATOM   924  O O    . PRO A 1 61  ? 14.16700  -24.11100 -0.71000  1.000 39.61000  ? 61  PRO A O    1 
ATOM   925  C CB   . PRO A 1 61  ? 15.06200  -21.28000 -1.29300  1.000 40.17000  ? 61  PRO A CB   1 
ATOM   926  C CG   . PRO A 1 61  ? 14.32700  -20.11100 -0.68700  1.000 40.35000  ? 61  PRO A CG   1 
ATOM   927  C CD   . PRO A 1 61  ? 13.16400  -19.81500 -1.61200  1.000 39.29000  ? 61  PRO A CD   1 
ATOM   928  H HA   . PRO A 1 61  ? 14.32100  -22.52100 -2.77100  1.000 43.92000  ? 61  PRO A HA   1 
ATOM   929  H HB2  . PRO A 1 61  ? 15.49400  -21.81100 -0.60600  1.000 45.22000  ? 61  PRO A HB2  1 
ATOM   930  H HB3  . PRO A 1 61  ? 15.70500  -20.97900 -1.95400  1.000 45.22000  ? 61  PRO A HB3  1 
ATOM   931  H HG2  . PRO A 1 61  ? 14.00600  -20.35300 0.19600   1.000 46.40000  ? 61  PRO A HG2  1 
ATOM   932  H HG3  . PRO A 1 61  ? 14.92200  -19.34700 -0.63400  1.000 46.40000  ? 61  PRO A HG3  1 
ATOM   933  H HD2  . PRO A 1 61  ? 12.37300  -19.59400 -1.09600  1.000 44.22000  ? 61  PRO A HD2  1 
ATOM   934  H HD3  . PRO A 1 61  ? 13.39500  -19.10300 -2.22900  1.000 44.22000  ? 61  PRO A HD3  1 
ATOM   935  N N    . LYS A 1 62  ? 12.16300  -23.09600 -0.62700  1.000 49.43000  ? 62  LYS A N    1 
ATOM   936  C CA   . LYS A 1 62  ? 11.55800  -24.06800 0.26900   1.000 50.24000  ? 62  LYS A CA   1 
ATOM   937  C C    . LYS A 1 62  ? 10.08300  -24.15600 -0.03900  1.000 49.34000  ? 62  LYS A C    1 
ATOM   938  O O    . LYS A 1 62  ? 9.51900   -23.25600 -0.68900  1.000 48.70000  ? 62  LYS A O    1 
ATOM   939  C CB   . LYS A 1 62  ? 11.76900  -23.68400 1.74100   1.000 51.05000  ? 62  LYS A CB   1 
ATOM   940  C CG   . LYS A 1 62  ? 11.19800  -22.31900 2.10700   1.000 51.15000  ? 62  LYS A CG   1 
ATOM   941  C CD   . LYS A 1 62  ? 11.57600  -21.90400 3.52500   1.000 51.63000  ? 62  LYS A CD   1 
ATOM   942  C CE   . LYS A 1 62  ? 10.57300  -22.40100 4.55700   1.000 52.36000  ? 62  LYS A CE   1 
ATOM   943  N NZ   . LYS A 1 62  ? 10.91500  -21.92200 5.92800   1.000 53.45000  ? 62  LYS A NZ   1 
ATOM   944  H H    . LYS A 1 62  ? 11.62600  -22.46500 -0.85600  1.000 43.46000  ? 62  LYS A H    1 
ATOM   945  H HA   . LYS A 1 62  ? 11.96700  -24.93300 0.11500   1.000 47.47000  ? 62  LYS A HA   1 
ATOM   946  H HB2  . LYS A 1 62  ? 11.33700  -24.34700 2.30200   1.000 49.25000  ? 62  LYS A HB2  1 
ATOM   947  H HB3  . LYS A 1 62  ? 12.72100  -23.66700 1.92600   1.000 49.25000  ? 62  LYS A HB3  1 
ATOM   948  H HG2  . LYS A 1 62  ? 11.54500  -21.65200 1.49400   1.000 53.87000  ? 62  LYS A HG2  1 
ATOM   949  H HG3  . LYS A 1 62  ? 10.23100  -22.35300 2.05100   1.000 53.87000  ? 62  LYS A HG3  1 
ATOM   950  H HD2  . LYS A 1 62  ? 12.44400  -22.27600 3.74500   1.000 52.19000  ? 62  LYS A HD2  1 
ATOM   951  H HD3  . LYS A 1 62  ? 11.60500  -20.93600 3.57500   1.000 52.19000  ? 62  LYS A HD3  1 
ATOM   952  H HE2  . LYS A 1 62  ? 9.69000   -22.06900 4.33100   1.000 59.11000  ? 62  LYS A HE2  1 
ATOM   953  H HE3  . LYS A 1 62  ? 10.57600  -23.37100 4.56500   1.000 59.11000  ? 62  LYS A HE3  1 
ATOM   954  H HZ1  . LYS A 1 62  ? 10.31700  -22.22400 6.51400   1.000 66.78000  ? 62  LYS A HZ1  1 
ATOM   955  H HZ2  . LYS A 1 62  ? 11.72200  -22.21700 6.16100   1.000 66.78000  ? 62  LYS A HZ2  1 
ATOM   956  H HZ3  . LYS A 1 62  ? 10.91600  -21.03200 5.94800   1.000 66.78000  ? 62  LYS A HZ3  1 
ATOM   957  N N    . PRO A 1 63  ? 9.39900   -25.21700 0.38900   1.000 39.49000  ? 63  PRO A N    1 
ATOM   958  C CA   . PRO A 1 63  ? 7.94100   -25.28700 0.22700   1.000 39.09000  ? 63  PRO A CA   1 
ATOM   959  C C    . PRO A 1 63  ? 7.25600   -24.23200 1.08800   1.000 39.34000  ? 63  PRO A C    1 
ATOM   960  O O    . PRO A 1 63  ? 7.41300   -24.21900 2.31000   1.000 40.36000  ? 63  PRO A O    1 
ATOM   961  C CB   . PRO A 1 63  ? 7.59100   -26.71100 0.68100   1.000 40.01000  ? 63  PRO A CB   1 
ATOM   962  C CG   . PRO A 1 63  ? 8.89600   -27.48600 0.59700   1.000 40.73000  ? 63  PRO A CG   1 
ATOM   963  C CD   . PRO A 1 63  ? 9.96600   -26.47800 0.91600   1.000 40.85000  ? 63  PRO A CD   1 
ATOM   964  H HA   . PRO A 1 63  ? 7.69100   -25.16700 -0.70300  1.000 40.46000  ? 63  PRO A HA   1 
ATOM   965  H HB2  . PRO A 1 63  ? 7.26200   -26.69200 1.59300   1.000 39.09000  ? 63  PRO A HB2  1 
ATOM   966  H HB3  . PRO A 1 63  ? 6.92700   -27.09100 0.08400   1.000 39.09000  ? 63  PRO A HB3  1 
ATOM   967  H HG2  . PRO A 1 63  ? 8.89400   -28.20300 1.25000   1.000 41.23000  ? 63  PRO A HG2  1 
ATOM   968  H HG3  . PRO A 1 63  ? 9.01100   -27.83700 -0.30000  1.000 41.23000  ? 63  PRO A HG3  1 
ATOM   969  H HD2  . PRO A 1 63  ? 10.10000  -26.41600 1.87500   1.000 47.39000  ? 63  PRO A HD2  1 
ATOM   970  H HD3  . PRO A 1 63  ? 10.78600  -26.70800 0.45400   1.000 47.39000  ? 63  PRO A HD3  1 
ATOM   971  N N    . ILE A 1 64  ? 6.50600   -23.34100 0.44500   1.000 41.07000  ? 64  ILE A N    1 
ATOM   972  C CA   . ILE A 1 64  ? 5.75000   -22.32100 1.17100   1.000 40.71000  ? 64  ILE A CA   1 
ATOM   973  C C    . ILE A 1 64  ? 4.35200   -22.81500 1.51200   1.000 41.11000  ? 64  ILE A C    1 
ATOM   974  O O    . ILE A 1 64  ? 3.92400   -22.75900 2.66800   1.000 41.72000  ? 64  ILE A O    1 
ATOM   975  C CB   . ILE A 1 64  ? 5.69200   -21.01200 0.35300   1.000 40.14000  ? 64  ILE A CB   1 
ATOM   976  C CG1  . ILE A 1 64  ? 7.09000   -20.62400 -0.12900  1.000 40.46000  ? 64  ILE A CG1  1 
ATOM   977  C CG2  . ILE A 1 64  ? 5.07500   -19.89500 1.18800   1.000 39.73000  ? 64  ILE A CG2  1 
ATOM   978  C CD1  . ILE A 1 64  ? 8.11800   -20.53000 0.97400   1.000 41.11000  ? 64  ILE A CD1  1 
ATOM   979  H H    . ILE A 1 64  ? 6.41700   -23.30500 -0.41000  1.000 45.39000  ? 64  ILE A H    1 
ATOM   980  H HA   . ILE A 1 64  ? 6.20300   -22.12900 2.00700   1.000 42.45000  ? 64  ILE A HA   1 
ATOM   981  H HB   . ILE A 1 64  ? 5.13000   -21.16200 -0.42300  1.000 43.53000  ? 64  ILE A HB   1 
ATOM   982  H HG12 . ILE A 1 64  ? 7.39900   -21.28600 -0.76800  1.000 47.38000  ? 64  ILE A HG12 1 
ATOM   983  H HG13 . ILE A 1 64  ? 7.04000   -19.75600 -0.55800  1.000 47.38000  ? 64  ILE A HG13 1 
ATOM   984  H HG21 . ILE A 1 64  ? 5.18800   -19.05300 0.72000   1.000 39.18000  ? 64  ILE A HG21 1 
ATOM   985  H HG22 . ILE A 1 64  ? 4.13100   -20.07800 1.31400   1.000 39.18000  ? 64  ILE A HG22 1 
ATOM   986  H HG23 . ILE A 1 64  ? 5.52400   -19.85800 2.04700   1.000 39.18000  ? 64  ILE A HG23 1 
ATOM   987  H HD11 . ILE A 1 64  ? 8.93800   -20.16300 0.60800   1.000 46.99000  ? 64  ILE A HD11 1 
ATOM   988  H HD12 . ILE A 1 64  ? 7.78100   -19.95000 1.67400   1.000 46.99000  ? 64  ILE A HD12 1 
ATOM   989  H HD13 . ILE A 1 64  ? 8.28400   -21.41600 1.33000   1.000 46.99000  ? 64  ILE A HD13 1 
ATOM   990  N N    . ARG A 1 65  ? 3.62200   -23.30000 0.51100   1.000 38.67000  ? 65  ARG A N    1 
ATOM   991  C CA   . ARG A 1 65  ? 2.30200   -23.89700 0.70800   1.000 38.66000  ? 65  ARG A CA   1 
ATOM   992  C C    . ARG A 1 65  ? 2.49300   -25.40800 0.77700   1.000 39.26000  ? 65  ARG A C    1 
ATOM   993  O O    . ARG A 1 65  ? 2.41600   -26.10900 -0.23200  1.000 39.74000  ? 65  ARG A O    1 
ATOM   994  C CB   . ARG A 1 65  ? 1.34700   -23.50000 -0.41200  1.000 37.68000  ? 65  ARG A CB   1 
ATOM   995  C CG   . ARG A 1 65  ? 0.76400   -22.10300 -0.27600  1.000 36.34000  ? 65  ARG A CG   1 
ATOM   996  C CD   . ARG A 1 65  ? -0.18300  -22.00500 0.91100   1.000 35.62000  ? 65  ARG A CD   1 
ATOM   997  N NE   . ARG A 1 65  ? -1.40700  -22.77700 0.72600   1.000 34.35000  ? 65  ARG A NE   1 
ATOM   998  C CZ   . ARG A 1 65  ? -2.52700  -22.29100 0.20600   1.000 32.61000  ? 65  ARG A CZ   1 
ATOM   999  N NH1  . ARG A 1 65  ? -2.60300  -21.04500 -0.23100  1.000 31.57000  ? 65  ARG A NH1  1 
ATOM   1000 N NH2  . ARG A 1 65  ? -3.59900  -23.07300 0.12800   1.000 32.69000  ? 65  ARG A NH2  1 
ATOM   1001 H H    . ARG A 1 65  ? 3.87500   -23.29500 -0.31100  1.000 47.87000  ? 65  ARG A H    1 
ATOM   1002 H HA   . ARG A 1 65  ? 1.93800   -23.60200 1.55500   1.000 47.01000  ? 65  ARG A HA   1 
ATOM   1003 H HB2  . ARG A 1 65  ? 1.82400   -23.53900 -1.25500  1.000 43.75000  ? 65  ARG A HB2  1 
ATOM   1004 H HB3  . ARG A 1 65  ? 0.60800   -24.12700 -0.42600  1.000 43.75000  ? 65  ARG A HB3  1 
ATOM   1005 H HG2  . ARG A 1 65  ? 1.48400   -21.46700 -0.14300  1.000 42.98000  ? 65  ARG A HG2  1 
ATOM   1006 H HG3  . ARG A 1 65  ? 0.26700   -21.88400 -1.08000  1.000 42.98000  ? 65  ARG A HG3  1 
ATOM   1007 H HD2  . ARG A 1 65  ? 0.25800   -22.33800 1.70600   1.000 44.52000  ? 65  ARG A HD2  1 
ATOM   1008 H HD3  . ARG A 1 65  ? -0.42500  -21.07600 1.04400   1.000 44.52000  ? 65  ARG A HD3  1 
ATOM   1009 H HE   . ARG A 1 65  ? -1.37600  -23.62100 0.88900   1.000 38.28000  ? 65  ARG A HE   1 
ATOM   1010 H HH11 . ARG A 1 65  ? -1.92000  -20.52600 -0.18700  1.000 40.95000  ? 65  ARG A HH11 1 
ATOM   1011 H HH12 . ARG A 1 65  ? -3.34000  -20.75400 -0.56400  1.000 40.95000  ? 65  ARG A HH12 1 
ATOM   1012 H HH21 . ARG A 1 65  ? -3.56000  -23.88500 0.40900   1.000 44.30000  ? 65  ARG A HH21 1 
ATOM   1013 H HH22 . ARG A 1 65  ? -4.32900  -22.76900 -0.20900  1.000 44.30000  ? 65  ARG A HH22 1 
ATOM   1014 N N    . THR A 1 66  ? 2.75000   -25.91200 1.98400   1.000 46.61000  ? 66  THR A N    1 
ATOM   1015 C CA   . THR A 1 66  ? 2.92300   -27.34700 2.17300   1.000 48.02000  ? 66  THR A CA   1 
ATOM   1016 C C    . THR A 1 66  ? 1.61900   -28.12300 2.05100   1.000 48.23000  ? 66  THR A C    1 
ATOM   1017 O O    . THR A 1 66  ? 1.64400   -29.35600 2.14200   1.000 49.14000  ? 66  THR A O    1 
ATOM   1018 C CB   . THR A 1 66  ? 3.55000   -27.62700 3.54100   1.000 49.01000  ? 66  THR A CB   1 
ATOM   1019 O OG1  . THR A 1 66  ? 2.83800   -26.90300 4.55500   1.000 48.19000  ? 66  THR A OG1  1 
ATOM   1020 C CG2  . THR A 1 66  ? 5.01300   -27.21300 3.55500   1.000 48.57000  ? 66  THR A CG2  1 
ATOM   1021 H H    . THR A 1 66  ? 2.82800   -25.44600 2.70200   1.000 46.74000  ? 66  THR A H    1 
ATOM   1022 H HA   . THR A 1 66  ? 3.53100   -27.68000 1.49400   1.000 51.38000  ? 66  THR A HA   1 
ATOM   1023 H HB   . THR A 1 66  ? 3.50000   -28.57700 3.72900   1.000 55.58000  ? 66  THR A HB   1 
ATOM   1024 H HG1  . THR A 1 66  ? 2.99100   -26.08000 4.48400   1.000 51.62000  ? 66  THR A HG1  1 
ATOM   1025 H HG21 . THR A 1 66  ? 5.40000   -27.39400 4.42600   1.000 50.07000  ? 66  THR A HG21 1 
ATOM   1026 H HG22 . THR A 1 66  ? 5.50400   -27.71000 2.88200   1.000 50.07000  ? 66  THR A HG22 1 
ATOM   1027 H HG23 . THR A 1 66  ? 5.09100   -26.26500 3.36600   1.000 50.07000  ? 66  THR A HG23 1 
ATOM   1028 N N    . ASP A 1 67  ? 0.49100   -27.44500 1.84800   1.000 47.05000  ? 67  ASP A N    1 
ATOM   1029 C CA   . ASP A 1 67  ? -0.80600  -28.10200 1.81600   1.000 46.31000  ? 67  ASP A CA   1 
ATOM   1030 C C    . ASP A 1 67  ? -1.32500  -28.34600 0.40700   1.000 46.32000  ? 67  ASP A C    1 
ATOM   1031 O O    . ASP A 1 67  ? -2.32400  -29.05700 0.25200   1.000 46.73000  ? 67  ASP A O    1 
ATOM   1032 C CB   . ASP A 1 67  ? -1.84000  -27.26800 2.58200   1.000 45.14000  ? 67  ASP A CB   1 
ATOM   1033 C CG   . ASP A 1 67  ? -2.05600  -25.89900 1.96700   1.000 43.47000  ? 67  ASP A CG   1 
ATOM   1034 O OD1  . ASP A 1 67  ? -1.05500  -25.23500 1.62700   1.000 43.79000  ? 67  ASP A OD1  1 
ATOM   1035 O OD2  . ASP A 1 67  ? -3.22600  -25.48700 1.81700   1.000 42.84000  ? 67  ASP A OD2  1 
ATOM   1036 H H    . ASP A 1 67  ? 0.45100   -26.59500 1.72600   1.000 52.40000  ? 67  ASP A H    1 
ATOM   1037 H HA   . ASP A 1 67  ? -0.73400  -28.96200 2.25800   1.000 45.65000  ? 67  ASP A HA   1 
ATOM   1038 H HB2  . ASP A 1 67  ? -2.68900  -27.73600 2.57900   1.000 46.24000  ? 67  ASP A HB2  1 
ATOM   1039 H HB3  . ASP A 1 67  ? -1.53300  -27.14300 3.49400   1.000 46.24000  ? 67  ASP A HB3  1 
ATOM   1040 N N    . VAL A 1 68  ? -0.68800  -27.78500 -0.61300  1.000 42.53000  ? 68  VAL A N    1 
ATOM   1041 C CA   . VAL A 1 68  ? -1.20400  -27.86100 -1.96800  1.000 41.92000  ? 68  VAL A CA   1 
ATOM   1042 C C    . VAL A 1 68  ? -0.45000  -28.93400 -2.73800  1.000 43.12000  ? 68  VAL A C    1 
ATOM   1043 O O    . VAL A 1 68  ? 0.65400   -29.35000 -2.37400  1.000 43.51000  ? 68  VAL A O    1 
ATOM   1044 C CB   . VAL A 1 68  ? -1.11400  -26.50100 -2.70100  1.000 40.44000  ? 68  VAL A CB   1 
ATOM   1045 C CG1  . VAL A 1 68  ? -1.72600  -25.39300 -1.85600  1.000 39.26000  ? 68  VAL A CG1  1 
ATOM   1046 C CG2  . VAL A 1 68  ? 0.33000   -26.18200 -3.06100  1.000 41.54000  ? 68  VAL A CG2  1 
ATOM   1047 H H    . VAL A 1 68  ? 0.05100   -27.35100 -0.54400  1.000 50.92000  ? 68  VAL A H    1 
ATOM   1048 H HA   . VAL A 1 68  ? -2.13900  -28.11800 -1.93800  1.000 50.63000  ? 68  VAL A HA   1 
ATOM   1049 H HB   . VAL A 1 68  ? -1.62000  -26.55700 -3.52700  1.000 47.47000  ? 68  VAL A HB   1 
ATOM   1050 H HG11 . VAL A 1 68  ? -1.68700  -24.56000 -2.35200  1.000 50.92000  ? 68  VAL A HG11 1 
ATOM   1051 H HG12 . VAL A 1 68  ? -2.64900  -25.61900 -1.66200  1.000 50.92000  ? 68  VAL A HG12 1 
ATOM   1052 H HG13 . VAL A 1 68  ? -1.22500  -25.31000 -1.03000  1.000 50.92000  ? 68  VAL A HG13 1 
ATOM   1053 H HG21 . VAL A 1 68  ? 0.40300   -25.23500 -3.26000  1.000 47.71000  ? 68  VAL A HG21 1 
ATOM   1054 H HG22 . VAL A 1 68  ? 0.89900   -26.40600 -2.30800  1.000 47.71000  ? 68  VAL A HG22 1 
ATOM   1055 H HG23 . VAL A 1 68  ? 0.58700   -26.70400 -3.83700  1.000 47.71000  ? 68  VAL A HG23 1 
ATOM   1056 N N    . THR A 1 69  ? -1.06200  -29.38900 -3.82500  1.000 52.93000  ? 69  THR A N    1 
ATOM   1057 C CA   . THR A 1 69  ? -0.44200  -30.30800 -4.76400  1.000 53.38000  ? 69  THR A CA   1 
ATOM   1058 C C    . THR A 1 69  ? 0.07600   -29.54000 -5.97700  1.000 52.39000  ? 69  THR A C    1 
ATOM   1059 O O    . THR A 1 69  ? -0.28000  -28.38300 -6.21400  1.000 51.87000  ? 69  THR A O    1 
ATOM   1060 C CB   . THR A 1 69  ? -1.43800  -31.38700 -5.20000  1.000 54.32000  ? 69  THR A CB   1 
ATOM   1061 O OG1  . THR A 1 69  ? -2.74200  -30.80900 -5.34800  1.000 53.84000  ? 69  THR A OG1  1 
ATOM   1062 C CG2  . THR A 1 69  ? -1.49200  -32.51200 -4.17600  1.000 55.76000  ? 69  THR A CG2  1 
ATOM   1063 H H    . THR A 1 69  ? -1.86400  -29.17000 -4.04500  1.000 53.72000  ? 69  THR A H    1 
ATOM   1064 H HA   . THR A 1 69  ? 0.31100   -30.74600 -4.33700  1.000 47.97000  ? 69  THR A HA   1 
ATOM   1065 H HB   . THR A 1 69  ? -1.15500  -31.76100 -6.04900  1.000 55.92000  ? 69  THR A HB   1 
ATOM   1066 H HG1  . THR A 1 69  ? -3.29200  -31.39700 -5.58700  1.000 67.50000  ? 69  THR A HG1  1 
ATOM   1067 H HG21 . THR A 1 69  ? -2.12800  -33.18700 -4.45900  1.000 59.73000  ? 69  THR A HG21 1 
ATOM   1068 H HG22 . THR A 1 69  ? -0.61700  -32.92100 -4.08700  1.000 59.73000  ? 69  THR A HG22 1 
ATOM   1069 H HG23 . THR A 1 69  ? -1.76600  -32.16200 -3.31400  1.000 59.73000  ? 69  THR A HG23 1 
ATOM   1070 N N    . GLY A 1 70  ? 0.92900   -30.20400 -6.75100  1.000 37.59000  ? 70  GLY A N    1 
ATOM   1071 C CA   . GLY A 1 70  ? 1.50500   -29.60000 -7.93600  1.000 36.64000  ? 70  GLY A CA   1 
ATOM   1072 C C    . GLY A 1 70  ? 0.60800   -29.77500 -9.15000  1.000 36.88000  ? 70  GLY A C    1 
ATOM   1073 O O    . GLY A 1 70  ? 0.05100   -30.84600 -9.38200  1.000 38.32000  ? 70  GLY A O    1 
ATOM   1074 H H    . GLY A 1 70  ? 1.18900   -31.01100 -6.60700  1.000 38.12000  ? 70  GLY A H    1 
ATOM   1075 H HA2  . GLY A 1 70  ? 1.64100   -28.65100 -7.78500  1.000 38.68000  ? 70  GLY A HA2  1 
ATOM   1076 H HA3  . GLY A 1 70  ? 2.36400   -30.00900 -8.12500  1.000 38.68000  ? 70  GLY A HA3  1 
ATOM   1077 N N    . MET A 1 71  ? 0.47300   -28.70000 -9.91800  1.000 51.77000  ? 71  MET A N    1 
ATOM   1078 C CA   . MET A 1 71  ? -0.24600  -28.70300 -11.18300 1.000 50.72000  ? 71  MET A CA   1 
ATOM   1079 C C    . MET A 1 71  ? 0.73700   -28.49200 -12.32800 1.000 50.02000  ? 71  MET A C    1 
ATOM   1080 O O    . MET A 1 71  ? 1.91800   -28.19800 -12.12300 1.000 49.37000  ? 71  MET A O    1 
ATOM   1081 C CB   . MET A 1 71  ? -1.32500  -27.61600 -11.19500 1.000 50.35000  ? 71  MET A CB   1 
ATOM   1082 C CG   . MET A 1 71  ? -2.50100  -27.89100 -10.27500 1.000 50.08000  ? 71  MET A CG   1 
ATOM   1083 S SD   . MET A 1 71  ? -3.57000  -26.44800 -10.08800 1.000 47.57000  ? 71  MET A SD   1 
ATOM   1084 C CE   . MET A 1 71  ? -3.85800  -26.00400 -11.80100 1.000 46.06000  ? 71  MET A CE   1 
ATOM   1085 H H    . MET A 1 71  ? 0.80200   -27.93100 -9.71800  1.000 48.24000  ? 71  MET A H    1 
ATOM   1086 H HA   . MET A 1 71  ? -0.68500  -29.56000 -11.29800 1.000 43.02000  ? 71  MET A HA   1 
ATOM   1087 H HB2  . MET A 1 71  ? -0.92400  -26.77700 -10.92000 1.000 50.38000  ? 71  MET A HB2  1 
ATOM   1088 H HB3  . MET A 1 71  ? -1.66800  -27.53500 -12.09800 1.000 50.38000  ? 71  MET A HB3  1 
ATOM   1089 H HG2  . MET A 1 71  ? -3.03100  -28.61400 -10.64400 1.000 52.39000  ? 71  MET A HG2  1 
ATOM   1090 H HG3  . MET A 1 71  ? -2.16800  -28.13600 -9.39700  1.000 52.39000  ? 71  MET A HG3  1 
ATOM   1091 H HE1  . MET A 1 71  ? -4.61400  -25.39900 -11.84600 1.000 50.47000  ? 71  MET A HE1  1 
ATOM   1092 H HE2  . MET A 1 71  ? -3.06500  -25.57100 -12.15300 1.000 50.47000  ? 71  MET A HE2  1 
ATOM   1093 H HE3  . MET A 1 71  ? -4.05000  -26.80900 -12.30700 1.000 50.47000  ? 71  MET A HE3  1 
ATOM   1094 N N    . ILE A 1 72  ? 0.34000   -28.67100 -13.52500 1.000 53.70000  ? 72  ILE A N    1 
ATOM   1095 C CA   . ILE A 1 72  ? 1.18800   -28.55200 -14.71800 1.000 52.31000  ? 72  ILE A CA   1 
ATOM   1096 C C    . ILE A 1 72  ? 1.07100   -27.12100 -15.20400 1.000 50.57000  ? 72  ILE A C    1 
ATOM   1097 O O    . ILE A 1 72  ? -0.01700  -26.74000 -15.53200 1.000 50.69000  ? 72  ILE A O    1 
ATOM   1098 C CB   . ILE A 1 72  ? 0.70800   -29.52300 -15.80900 1.000 54.02000  ? 72  ILE A CB   1 
ATOM   1099 C CG1  . ILE A 1 72  ? 0.55700   -30.94500 -15.29700 1.000 56.25000  ? 72  ILE A CG1  1 
ATOM   1100 C CG2  . ILE A 1 72  ? 1.62200   -29.45400 -17.03100 1.000 53.34000  ? 72  ILE A CG2  1 
ATOM   1101 C CD1  . ILE A 1 72  ? -0.52800  -31.72500 -16.01400 1.000 56.99000  ? 72  ILE A CD1  1 
ATOM   1102 H H    . ILE A 1 72  ? -0.47200  -28.87900 -13.71900 1.000 49.50000  ? 72  ILE A H    1 
ATOM   1103 H HA   . ILE A 1 72  ? 2.11300   -28.74500 -14.49900 1.000 45.31000  ? 72  ILE A HA   1 
ATOM   1104 H HB   . ILE A 1 72  ? -0.17100  -29.22500 -16.09100 1.000 54.48000  ? 72  ILE A HB   1 
ATOM   1105 H HG12 . ILE A 1 72  ? 1.39500   -31.41600 -15.42800 1.000 59.62000  ? 72  ILE A HG12 1 
ATOM   1106 H HG13 . ILE A 1 72  ? 0.33400   -30.93400 -14.35400 1.000 59.62000  ? 72  ILE A HG13 1 
ATOM   1107 H HG21 . ILE A 1 72  ? 2.39700   -30.01700 -16.87700 1.000 54.05000  ? 72  ILE A HG21 1 
ATOM   1108 H HG22 . ILE A 1 72  ? 1.13300   -29.77200 -17.80600 1.000 54.05000  ? 72  ILE A HG22 1 
ATOM   1109 H HG23 . ILE A 1 72  ? 1.90600   -28.54000 -17.17400 1.000 54.05000  ? 72  ILE A HG23 1 
ATOM   1110 H HD11 . ILE A 1 72  ? -0.56600  -32.62200 -15.64700 1.000 59.36000  ? 72  ILE A HD11 1 
ATOM   1111 H HD12 . ILE A 1 72  ? -1.37800  -31.27700 -15.88200 1.000 59.36000  ? 72  ILE A HD12 1 
ATOM   1112 H HD13 . ILE A 1 72  ? -0.31600  -31.76300 -16.96000 1.000 59.36000  ? 72  ILE A HD13 1 
ATOM   1113 N N    . LEU A 1 73  ? 2.13100   -26.42900 -15.36400 1.000 39.50000  ? 73  LEU A N    1 
ATOM   1114 C CA   . LEU A 1 73  ? 2.23600   -25.11300 -15.98100 1.000 37.36000  ? 73  LEU A CA   1 
ATOM   1115 C C    . LEU A 1 73  ? 2.66600   -25.30000 -17.43000 1.000 37.53000  ? 73  LEU A C    1 
ATOM   1116 O O    . LEU A 1 73  ? 3.74700   -25.83600 -17.69600 1.000 37.85000  ? 73  LEU A O    1 
ATOM   1117 C CB   . LEU A 1 73  ? 3.23100   -24.22700 -15.23300 1.000 36.03000  ? 73  LEU A CB   1 
ATOM   1118 C CG   . LEU A 1 73  ? 3.50000   -22.86800 -15.88400 1.000 34.58000  ? 73  LEU A CG   1 
ATOM   1119 C CD1  . LEU A 1 73  ? 2.19500   -22.11300 -16.10300 1.000 33.55000  ? 73  LEU A CD1  1 
ATOM   1120 C CD2  . LEU A 1 73  ? 4.46900   -22.04600 -15.04700 1.000 34.31000  ? 73  LEU A CD2  1 
ATOM   1121 H H    . LEU A 1 73  ? 2.89900   -26.71300 -15.10100 1.000 50.41000  ? 73  LEU A H    1 
ATOM   1122 H HA   . LEU A 1 73  ? 1.36700   -24.68300 -15.97000 1.000 48.34000  ? 73  LEU A HA   1 
ATOM   1123 H HB2  . LEU A 1 73  ? 2.88700   -24.06200 -14.34100 1.000 44.99000  ? 73  LEU A HB2  1 
ATOM   1124 H HB3  . LEU A 1 73  ? 4.07800   -24.69600 -15.17400 1.000 44.99000  ? 73  LEU A HB3  1 
ATOM   1125 H HG   . LEU A 1 73  ? 3.91000   -23.01000 -16.75200 1.000 44.36000  ? 73  LEU A HG   1 
ATOM   1126 H HD11 . LEU A 1 73  ? 2.40000   -21.20800 -16.38700 1.000 43.10000  ? 73  LEU A HD11 1 
ATOM   1127 H HD12 . LEU A 1 73  ? 1.67700   -22.56400 -16.78800 1.000 43.10000  ? 73  LEU A HD12 1 
ATOM   1128 H HD13 . LEU A 1 73  ? 1.69900   -22.09200 -15.27000 1.000 43.10000  ? 73  LEU A HD13 1 
ATOM   1129 H HD21 . LEU A 1 73  ? 4.62000   -21.19400 -15.48500 1.000 43.11000  ? 73  LEU A HD21 1 
ATOM   1130 H HD22 . LEU A 1 73  ? 4.08400   -21.90300 -14.16800 1.000 43.11000  ? 73  LEU A HD22 1 
ATOM   1131 H HD23 . LEU A 1 73  ? 5.30600   -22.53000 -14.96700 1.000 43.11000  ? 73  LEU A HD23 1 
ATOM   1132 N N    . GLU A 1 74  ? 1.81900   -24.87000 -18.36100 1.000 40.73000  ? 74  GLU A N    1 
ATOM   1133 C CA   . GLU A 1 74  ? 2.09800   -24.98900 -19.78400 1.000 40.70000  ? 74  GLU A CA   1 
ATOM   1134 C C    . GLU A 1 74  ? 1.82900   -23.65800 -20.46600 1.000 39.29000  ? 74  GLU A C    1 
ATOM   1135 O O    . GLU A 1 74  ? 1.01600   -22.85400 -20.00200 1.000 38.38000  ? 74  GLU A O    1 
ATOM   1136 C CB   . GLU A 1 74  ? 1.26000   -26.10400 -20.42400 1.000 42.45000  ? 74  GLU A CB   1 
ATOM   1137 C CG   . GLU A 1 74  ? 1.74600   -27.49800 -20.05300 1.000 44.60000  ? 74  GLU A CG   1 
ATOM   1138 C CD   . GLU A 1 74  ? 0.99000   -28.60200 -20.76400 1.000 46.61000  ? 74  GLU A CD   1 
ATOM   1139 O OE1  . GLU A 1 74  ? -0.10200  -28.32800 -21.30800 1.000 46.50000  ? 74  GLU A OE1  1 
ATOM   1140 O OE2  . GLU A 1 74  ? 1.49000   -29.74700 -20.78300 1.000 47.33000  ? 74  GLU A OE2  1 
ATOM   1141 H H    . GLU A 1 74  ? 1.06300   -24.49900 -18.18800 1.000 49.89000  ? 74  GLU A H    1 
ATOM   1142 H HA   . GLU A 1 74  ? 3.03500   -25.20700 -19.91000 1.000 44.91000  ? 74  GLU A HA   1 
ATOM   1143 H HB2  . GLU A 1 74  ? 0.34100   -26.01800 -20.12600 1.000 47.15000  ? 74  GLU A HB2  1 
ATOM   1144 H HB3  . GLU A 1 74  ? 1.30500   -26.01800 -21.38900 1.000 47.15000  ? 74  GLU A HB3  1 
ATOM   1145 H HG2  . GLU A 1 74  ? 2.68400   -27.57800 -20.28600 1.000 55.62000  ? 74  GLU A HG2  1 
ATOM   1146 H HG3  . GLU A 1 74  ? 1.63000   -27.62300 -19.10000 1.000 55.62000  ? 74  GLU A HG3  1 
ATOM   1147 N N    . GLU A 1 75  ? 2.53500   -23.42700 -21.57000 1.000 44.28000  ? 75  GLU A N    1 
ATOM   1148 C CA   . GLU A 1 75  ? 2.45600   -22.16400 -22.30000 1.000 44.10000  ? 75  GLU A CA   1 
ATOM   1149 C C    . GLU A 1 75  ? 1.26600   -22.21800 -23.24800 1.000 44.31000  ? 75  GLU A C    1 
ATOM   1150 O O    . GLU A 1 75  ? 1.35900   -22.75400 -24.35400 1.000 45.56000  ? 75  GLU A O    1 
ATOM   1151 C CB   . GLU A 1 75  ? 3.75700   -21.89700 -23.04800 1.000 45.20000  ? 75  GLU A CB   1 
ATOM   1152 C CG   . GLU A 1 75  ? 3.61600   -20.92200 -24.20700 1.000 46.48000  ? 75  GLU A CG   1 
ATOM   1153 C CD   . GLU A 1 75  ? 4.85600   -20.07500 -24.40800 1.000 47.43000  ? 75  GLU A CD   1 
ATOM   1154 O OE1  . GLU A 1 75  ? 4.96200   -19.01600 -23.75200 1.000 46.28000  ? 75  GLU A OE1  1 
ATOM   1155 O OE2  . GLU A 1 75  ? 5.72700   -20.47100 -25.21100 1.000 49.79000  ? 75  GLU A OE2  1 
ATOM   1156 H H    . GLU A 1 75  ? 3.07600   -23.99600 -21.92200 1.000 40.24000  ? 75  GLU A H    1 
ATOM   1157 H HA   . GLU A 1 75  ? 2.31200   -21.43900 -21.67200 1.000 44.40000  ? 75  GLU A HA   1 
ATOM   1158 H HB2  . GLU A 1 75  ? 4.40300   -21.52700 -22.42700 1.000 52.22000  ? 75  GLU A HB2  1 
ATOM   1159 H HB3  . GLU A 1 75  ? 4.08900   -22.73500 -23.40600 1.000 52.22000  ? 75  GLU A HB3  1 
ATOM   1160 H HG2  . GLU A 1 75  ? 3.45400   -21.42000 -25.02400 1.000 63.94000  ? 75  GLU A HG2  1 
ATOM   1161 H HG3  . GLU A 1 75  ? 2.87800   -20.31800 -24.03200 1.000 63.94000  ? 75  GLU A HG3  1 
ATOM   1162 N N    . GLY A 1 76  ? 0.14600   -21.64700 -22.81500 1.000 38.12000  ? 76  GLY A N    1 
ATOM   1163 C CA   . GLY A 1 76  ? -1.03600  -21.57200 -23.64600 1.000 38.52000  ? 76  GLY A CA   1 
ATOM   1164 C C    . GLY A 1 76  ? -1.77500  -22.89200 -23.73400 1.000 39.57000  ? 76  GLY A C    1 
ATOM   1165 O O    . GLY A 1 76  ? -1.37000  -23.92100 -23.19100 1.000 40.21000  ? 76  GLY A O    1 
ATOM   1166 H H    . GLY A 1 76  ? 0.05000   -21.29400 -22.03600 1.000 46.19000  ? 76  GLY A H    1 
ATOM   1167 H HA2  . GLY A 1 76  ? -1.64200  -20.90600 -23.28500 1.000 41.04000  ? 76  GLY A HA2  1 
ATOM   1168 H HA3  . GLY A 1 76  ? -0.78300  -21.30300 -24.54300 1.000 41.04000  ? 76  GLY A HA3  1 
ATOM   1169 N N    . ALA A 1 77  ? -2.89600  -22.84700 -24.44500 1.000 35.40000  ? 77  ALA A N    1 
ATOM   1170 C CA   . ALA A 1 77  ? -3.74700  -24.00100 -24.66800 1.000 36.68000  ? 77  ALA A CA   1 
ATOM   1171 C C    . ALA A 1 77  ? -3.96900  -24.19300 -26.16000 1.000 38.07000  ? 77  ALA A C    1 
ATOM   1172 O O    . ALA A 1 77  ? -3.89700  -23.23000 -26.93100 1.000 38.20000  ? 77  ALA A O    1 
ATOM   1173 C CB   . ALA A 1 77  ? -5.10200  -23.83400 -23.96400 1.000 37.39000  ? 77  ALA A CB   1 
ATOM   1174 H H    . ALA A 1 77  ? -3.19100  -22.13200 -24.82000 1.000 39.61000  ? 77  ALA A H    1 
ATOM   1175 H HA   . ALA A 1 77  ? -3.31000  -24.78500 -24.30600 1.000 38.07000  ? 77  ALA A HA   1 
ATOM   1176 H HB1  . ALA A 1 77  ? -5.64800  -24.61500 -24.14400 1.000 41.76000  ? 77  ALA A HB1  1 
ATOM   1177 H HB2  . ALA A 1 77  ? -4.95800  -23.74600 -23.01100 1.000 41.76000  ? 77  ALA A HB2  1 
ATOM   1178 H HB3  . ALA A 1 77  ? -5.53900  -23.03900 -24.30800 1.000 41.76000  ? 77  ALA A HB3  1 
ATOM   1179 N N    . PRO A 1 78  ? -4.22200  -25.42500 -26.59800 1.000 40.90000  ? 78  PRO A N    1 
ATOM   1180 C CA   . PRO A 1 78  ? -4.56400  -25.63800 -28.01100 1.000 42.44000  ? 78  PRO A CA   1 
ATOM   1181 C C    . PRO A 1 78  ? -5.76800  -24.79000 -28.39800 1.000 42.80000  ? 78  PRO A C    1 
ATOM   1182 O O    . PRO A 1 78  ? -6.72400  -24.65400 -27.63200 1.000 42.56000  ? 78  PRO A O    1 
ATOM   1183 C CB   . PRO A 1 78  ? -4.86900  -27.14100 -28.08300 1.000 43.37000  ? 78  PRO A CB   1 
ATOM   1184 C CG   . PRO A 1 78  ? -4.14800  -27.73900 -26.88500 1.000 43.24000  ? 78  PRO A CG   1 
ATOM   1185 C CD   . PRO A 1 78  ? -4.22500  -26.67800 -25.82200 1.000 42.24000  ? 78  PRO A CD   1 
ATOM   1186 H HA   . PRO A 1 78  ? -3.81100  -25.42600 -28.58500 1.000 45.18000  ? 78  PRO A HA   1 
ATOM   1187 H HB2  . PRO A 1 78  ? -5.82600  -27.28500 -28.01600 1.000 41.38000  ? 78  PRO A HB2  1 
ATOM   1188 H HB3  . PRO A 1 78  ? -4.52200  -27.50700 -28.91200 1.000 41.38000  ? 78  PRO A HB3  1 
ATOM   1189 H HG2  . PRO A 1 78  ? -4.60200  -28.54700 -26.59800 1.000 44.78000  ? 78  PRO A HG2  1 
ATOM   1190 H HG3  . PRO A 1 78  ? -3.22500  -27.92700 -27.11800 1.000 44.78000  ? 78  PRO A HG3  1 
ATOM   1191 H HD2  . PRO A 1 78  ? -5.04900  -26.76300 -25.31700 1.000 48.49000  ? 78  PRO A HD2  1 
ATOM   1192 H HD3  . PRO A 1 78  ? -3.44600  -26.72800 -25.24700 1.000 48.49000  ? 78  PRO A HD3  1 
ATOM   1193 N N    . GLU A 1 79  ? -5.70800  -24.19700 -29.58900 1.000 53.56000  ? 79  GLU A N    1 
ATOM   1194 C CA   . GLU A 1 79  ? -6.78300  -23.31500 -30.02500 1.000 53.67000  ? 79  GLU A CA   1 
ATOM   1195 C C    . GLU A 1 79  ? -8.11100  -24.06300 -30.01300 1.000 54.63000  ? 79  GLU A C    1 
ATOM   1196 O O    . GLU A 1 79  ? -8.18500  -25.24200 -30.37200 1.000 55.92000  ? 79  GLU A O    1 
ATOM   1197 C CB   . GLU A 1 79  ? -6.49300  -22.76600 -31.42100 1.000 54.58000  ? 79  GLU A CB   1 
ATOM   1198 C CG   . GLU A 1 79  ? -7.19400  -21.44800 -31.71400 1.000 55.01000  ? 79  GLU A CG   1 
ATOM   1199 C CD   . GLU A 1 79  ? -6.80400  -20.86600 -33.05600 1.000 56.62000  ? 79  GLU A CD   1 
ATOM   1200 O OE1  . GLU A 1 79  ? -5.64400  -20.42600 -33.20400 1.000 56.39000  ? 79  GLU A OE1  1 
ATOM   1201 O OE2  . GLU A 1 79  ? -7.65800  -20.85900 -33.96700 1.000 59.79000  ? 79  GLU A OE2  1 
ATOM   1202 H H    . GLU A 1 79  ? -5.06600  -24.28800 -30.15400 1.000 48.75000  ? 79  GLU A H    1 
ATOM   1203 H HA   . GLU A 1 79  ? -6.85100  -22.56600 -29.41200 1.000 46.08000  ? 79  GLU A HA   1 
ATOM   1204 H HB2  . GLU A 1 79  ? -5.53800  -22.62000 -31.50800 1.000 50.28000  ? 79  GLU A HB2  1 
ATOM   1205 H HB3  . GLU A 1 79  ? -6.78900  -23.41300 -32.08000 1.000 50.28000  ? 79  GLU A HB3  1 
ATOM   1206 H HG2  . GLU A 1 79  ? -8.15300  -21.59100 -31.71400 1.000 54.74000  ? 79  GLU A HG2  1 
ATOM   1207 H HG3  . GLU A 1 79  ? -6.95200  -20.81000 -31.02900 1.000 54.74000  ? 79  GLU A HG3  1 
ATOM   1208 N N    . GLY A 1 80  ? -9.16600  -23.36900 -29.58700 1.000 32.56000  ? 80  GLY A N    1 
ATOM   1209 C CA   . GLY A 1 80  ? -10.46700 -23.96900 -29.41600 1.000 32.94000  ? 80  GLY A CA   1 
ATOM   1210 C C    . GLY A 1 80  ? -10.73500 -24.50000 -28.02600 1.000 32.96000  ? 80  GLY A C    1 
ATOM   1211 O O    . GLY A 1 80  ? -11.89600 -24.75500 -27.68600 1.000 33.27000  ? 80  GLY A O    1 
ATOM   1212 H H    . GLY A 1 80  ? -9.14300  -22.53200 -29.38900 1.000 41.54000  ? 80  GLY A H    1 
ATOM   1213 H HA2  . GLY A 1 80  ? -11.14800 -23.30900 -29.62100 1.000 35.85000  ? 80  GLY A HA2  1 
ATOM   1214 H HA3  . GLY A 1 80  ? -10.56300 -24.70400 -30.04200 1.000 35.85000  ? 80  GLY A HA3  1 
ATOM   1215 N N    . THR A 1 81  ? -9.69500  -24.67700 -27.21600 1.000 34.12000  ? 81  THR A N    1 
ATOM   1216 C CA   . THR A 1 81  ? -9.88200  -25.10700 -25.84000 1.000 33.42000  ? 81  THR A CA   1 
ATOM   1217 C C    . THR A 1 81  ? -10.63600 -24.04300 -25.05500 1.000 32.51000  ? 81  THR A C    1 
ATOM   1218 O O    . THR A 1 81  ? -10.32100 -22.85200 -25.13800 1.000 32.07000  ? 81  THR A O    1 
ATOM   1219 C CB   . THR A 1 81  ? -8.52600  -25.37500 -25.18400 1.000 32.35000  ? 81  THR A CB   1 
ATOM   1220 O OG1  . THR A 1 81  ? -7.82700  -26.39000 -25.91500 1.000 32.86000  ? 81  THR A OG1  1 
ATOM   1221 C CG2  . THR A 1 81  ? -8.71000  -25.81800 -23.74000 1.000 31.87000  ? 81  THR A CG2  1 
ATOM   1222 H H    . THR A 1 81  ? -8.87400  -24.55500 -27.44000 1.000 47.49000  ? 81  THR A H    1 
ATOM   1223 H HA   . THR A 1 81  ? -10.40000 -25.92700 -25.82400 1.000 43.16000  ? 81  THR A HA   1 
ATOM   1224 H HB   . THR A 1 81  ? -8.00200  -24.55900 -25.18800 1.000 40.01000  ? 81  THR A HB   1 
ATOM   1225 H HG1  . THR A 1 81  ? -7.70000  -26.13800 -26.70600 1.000 38.98000  ? 81  THR A HG1  1 
ATOM   1226 H HG21 . THR A 1 81  ? -7.87700  -26.17800 -23.39700 1.000 37.51000  ? 81  THR A HG21 1 
ATOM   1227 H HG22 . THR A 1 81  ? -8.97600  -25.06500 -23.19000 1.000 37.51000  ? 81  THR A HG22 1 
ATOM   1228 H HG23 . THR A 1 81  ? -9.39300  -26.50500 -23.68900 1.000 37.51000  ? 81  THR A HG23 1 
ATOM   1229 N N    . VAL A 1 82  ? -11.63600 -24.47400 -24.29300 1.000 33.48000  ? 82  VAL A N    1 
ATOM   1230 C CA   . VAL A 1 82  ? -12.32900 -23.61300 -23.34300 1.000 33.52000  ? 82  VAL A CA   1 
ATOM   1231 C C    . VAL A 1 82  ? -11.71000 -23.83900 -21.97300 1.000 32.02000  ? 82  VAL A C    1 
ATOM   1232 O O    . VAL A 1 82  ? -11.56800 -24.98600 -21.53100 1.000 32.25000  ? 82  VAL A O    1 
ATOM   1233 C CB   . VAL A 1 82  ? -13.84000 -23.89800 -23.32000 1.000 34.02000  ? 82  VAL A CB   1 
ATOM   1234 C CG1  . VAL A 1 82  ? -14.51700 -23.04200 -22.25700 1.000 33.28000  ? 82  VAL A CG1  1 
ATOM   1235 C CG2  . VAL A 1 82  ? -14.45000 -23.64600 -24.69000 1.000 34.73000  ? 82  VAL A CG2  1 
ATOM   1236 H H    . VAL A 1 82  ? -11.93700 -25.27900 -24.30900 1.000 39.44000  ? 82  VAL A H    1 
ATOM   1237 H HA   . VAL A 1 82  ? -12.19600 -22.68500 -23.58700 1.000 44.21000  ? 82  VAL A HA   1 
ATOM   1238 H HB   . VAL A 1 82  ? -13.98400 -24.83000 -23.09300 1.000 41.09000  ? 82  VAL A HB   1 
ATOM   1239 H HG11 . VAL A 1 82  ? -15.47600 -23.06200 -22.40200 1.000 37.62000  ? 82  VAL A HG11 1 
ATOM   1240 H HG12 . VAL A 1 82  ? -14.30900 -23.40000 -21.38000 1.000 37.62000  ? 82  VAL A HG12 1 
ATOM   1241 H HG13 . VAL A 1 82  ? -14.19100 -22.13100 -22.33100 1.000 37.62000  ? 82  VAL A HG13 1 
ATOM   1242 H HG21 . VAL A 1 82  ? -15.40700 -23.80000 -24.64200 1.000 38.05000  ? 82  VAL A HG21 1 
ATOM   1243 H HG22 . VAL A 1 82  ? -14.27500 -22.72800 -24.94900 1.000 38.05000  ? 82  VAL A HG22 1 
ATOM   1244 H HG23 . VAL A 1 82  ? -14.04900 -24.25300 -25.33100 1.000 38.05000  ? 82  VAL A HG23 1 
ATOM   1245 N N    . VAL A 1 83  ? -11.32800 -22.75400 -21.30500 1.000 40.86000  ? 83  VAL A N    1 
ATOM   1246 C CA   . VAL A 1 83  ? -10.71200 -22.81800 -19.99100 1.000 40.31000  ? 83  VAL A CA   1 
ATOM   1247 C C    . VAL A 1 83  ? -11.51600 -21.94500 -19.03400 1.000 39.21000  ? 83  VAL A C    1 
ATOM   1248 O O    . VAL A 1 83  ? -12.48500 -21.29200 -19.42000 1.000 39.70000  ? 83  VAL A O    1 
ATOM   1249 C CB   . VAL A 1 83  ? -9.23300  -22.38200 -20.01500 1.000 39.35000  ? 83  VAL A CB   1 
ATOM   1250 C CG1  . VAL A 1 83  ? -8.48300  -23.10600 -21.12200 1.000 39.71000  ? 83  VAL A CG1  1 
ATOM   1251 C CG2  . VAL A 1 83  ? -9.13200  -20.87200 -20.17600 1.000 38.96000  ? 83  VAL A CG2  1 
ATOM   1252 H H    . VAL A 1 83  ? -11.41900 -21.95200 -21.60200 1.000 41.83000  ? 83  VAL A H    1 
ATOM   1253 H HA   . VAL A 1 83  ? -10.74900 -23.73100 -19.66500 1.000 50.01000  ? 83  VAL A HA   1 
ATOM   1254 H HB   . VAL A 1 83  ? -8.82100  -22.62000 -19.17000 1.000 45.18000  ? 83  VAL A HB   1 
ATOM   1255 H HG11 . VAL A 1 83  ? -7.53100  -23.06300 -20.94000 1.000 41.78000  ? 83  VAL A HG11 1 
ATOM   1256 H HG12 . VAL A 1 83  ? -8.77400  -24.03000 -21.15000 1.000 41.78000  ? 83  VAL A HG12 1 
ATOM   1257 H HG13 . VAL A 1 83  ? -8.67900  -22.67500 -21.96800 1.000 41.78000  ? 83  VAL A HG13 1 
ATOM   1258 H HG21 . VAL A 1 83  ? -8.24000  -20.64800 -20.48500 1.000 40.66000  ? 83  VAL A HG21 1 
ATOM   1259 H HG22 . VAL A 1 83  ? -9.79100  -20.58000 -20.82600 1.000 40.66000  ? 83  VAL A HG22 1 
ATOM   1260 H HG23 . VAL A 1 83  ? -9.30100  -20.44800 -19.32000 1.000 40.66000  ? 83  VAL A HG23 1 
ATOM   1261 N N    . THR A 1 84  ? -11.08700 -21.93000 -17.77400 1.000 38.94000  ? 84  THR A N    1 
ATOM   1262 C CA   . THR A 1 84  ? -11.78200 -21.21200 -16.71500 1.000 38.45000  ? 84  THR A CA   1 
ATOM   1263 C C    . THR A 1 84  ? -10.86200 -20.14700 -16.13500 1.000 37.15000  ? 84  THR A C    1 
ATOM   1264 O O    . THR A 1 84  ? -9.79700  -20.46900 -15.59800 1.000 36.24000  ? 84  THR A O    1 
ATOM   1265 C CB   . THR A 1 84  ? -12.24200 -22.16900 -15.61300 1.000 37.90000  ? 84  THR A CB   1 
ATOM   1266 O OG1  . THR A 1 84  ? -13.27400 -23.02800 -16.11400 1.000 39.99000  ? 84  THR A OG1  1 
ATOM   1267 C CG2  . THR A 1 84  ? -12.76500 -21.38600 -14.42000 1.000 37.06000  ? 84  THR A CG2  1 
ATOM   1268 H H    . THR A 1 84  ? -10.38000 -22.33800 -17.50500 1.000 41.03000  ? 84  THR A H    1 
ATOM   1269 H HA   . THR A 1 84  ? -12.56500 -20.77100 -17.08100 1.000 44.07000  ? 84  THR A HA   1 
ATOM   1270 H HB   . THR A 1 84  ? -11.49000 -22.70700 -15.32000 1.000 41.68000  ? 84  THR A HB   1 
ATOM   1271 H HG1  . THR A 1 84  ? -13.52800 -23.55400 -15.51100 1.000 51.68000  ? 84  THR A HG1  1 
ATOM   1272 H HG21 . THR A 1 84  ? -13.26300 -21.97600 -13.83300 1.000 42.10000  ? 84  THR A HG21 1 
ATOM   1273 H HG22 . THR A 1 84  ? -12.03100 -20.99700 -13.92200 1.000 42.10000  ? 84  THR A HG22 1 
ATOM   1274 H HG23 . THR A 1 84  ? -13.35300 -20.67600 -14.72300 1.000 42.10000  ? 84  THR A HG23 1 
ATOM   1275 N N    . LEU A 1 85  ? -11.28800 -18.88900 -16.22300 1.000 55.96000  ? 85  LEU A N    1 
ATOM   1276 C CA   . LEU A 1 85  ? -10.59300 -17.78100 -15.57500 1.000 55.98000  ? 85  LEU A CA   1 
ATOM   1277 C C    . LEU A 1 85  ? -11.09900 -17.67200 -14.14200 1.000 54.85000  ? 85  LEU A C    1 
ATOM   1278 O O    . LEU A 1 85  ? -12.22500 -17.22200 -13.90700 1.000 55.68000  ? 85  LEU A O    1 
ATOM   1279 C CB   . LEU A 1 85  ? -10.83400 -16.48200 -16.33800 1.000 57.31000  ? 85  LEU A CB   1 
ATOM   1280 C CG   . LEU A 1 85  ? -10.13800 -15.22100 -15.81900 1.000 58.61000  ? 85  LEU A CG   1 
ATOM   1281 C CD1  . LEU A 1 85  ? -8.62800  -15.32600 -15.98400 1.000 57.44000  ? 85  LEU A CD1  1 
ATOM   1282 C CD2  . LEU A 1 85  ? -10.69600 -13.98900 -16.53300 1.000 61.33000  ? 85  LEU A CD2  1 
ATOM   1283 H H    . LEU A 1 85  ? -11.98900 -18.64900 -16.66000 1.000 46.25000  ? 85  LEU A H    1 
ATOM   1284 H HA   . LEU A 1 85  ? -9.64000  -17.95900 -15.55600 1.000 55.31000  ? 85  LEU A HA   1 
ATOM   1285 H HB2  . LEU A 1 85  ? -10.54100 -16.61300 -17.25300 1.000 49.22000  ? 85  LEU A HB2  1 
ATOM   1286 H HB3  . LEU A 1 85  ? -11.78700 -16.30300 -16.33200 1.000 49.22000  ? 85  LEU A HB3  1 
ATOM   1287 H HG   . LEU A 1 85  ? -10.32000 -15.13100 -14.87400 1.000 62.27000  ? 85  LEU A HG   1 
ATOM   1288 H HD11 . LEU A 1 85  ? -8.34200  -14.63800 -16.60100 1.000 61.23000  ? 85  LEU A HD11 1 
ATOM   1289 H HD12 . LEU A 1 85  ? -8.20500  -15.19600 -15.12100 1.000 61.23000  ? 85  LEU A HD12 1 
ATOM   1290 H HD13 . LEU A 1 85  ? -8.40600  -16.20200 -16.33600 1.000 61.23000  ? 85  LEU A HD13 1 
ATOM   1291 H HD21 . LEU A 1 85  ? -10.24300 -13.19900 -16.20000 1.000 61.02000  ? 85  LEU A HD21 1 
ATOM   1292 H HD22 . LEU A 1 85  ? -10.54300 -14.08100 -17.48600 1.000 61.02000  ? 85  LEU A HD22 1 
ATOM   1293 H HD23 . LEU A 1 85  ? -11.64700 -13.92500 -16.35500 1.000 61.02000  ? 85  LEU A HD23 1 
ATOM   1294 N N    . LEU A 1 86  ? -10.27900 -18.08500 -13.17700 1.000 34.74000  ? 86  LEU A N    1 
ATOM   1295 C CA   . LEU A 1 86  ? -10.69600 -18.07600 -11.77500 1.000 33.89000  ? 86  LEU A CA   1 
ATOM   1296 C C    . LEU A 1 86  ? -10.46300 -16.68500 -11.20300 1.000 33.88000  ? 86  LEU A C    1 
ATOM   1297 O O    . LEU A 1 86  ? -9.41600  -16.39000 -10.62300 1.000 33.37000  ? 86  LEU A O    1 
ATOM   1298 C CB   . LEU A 1 86  ? -9.94900  -19.13200 -10.97200 1.000 33.37000  ? 86  LEU A CB   1 
ATOM   1299 C CG   . LEU A 1 86  ? -10.50600 -20.55500 -10.95900 1.000 34.42000  ? 86  LEU A CG   1 
ATOM   1300 C CD1  . LEU A 1 86  ? -10.02400 -21.33300 -12.16900 1.000 35.48000  ? 86  LEU A CD1  1 
ATOM   1301 C CD2  . LEU A 1 86  ? -10.11200 -21.24800 -9.65800  1.000 33.91000  ? 86  LEU A CD2  1 
ATOM   1302 H H    . LEU A 1 86  ? -9.47900  -18.37400 -13.30600 1.000 43.44000  ? 86  LEU A H    1 
ATOM   1303 H HA   . LEU A 1 86  ? -11.64500 -18.27100 -11.72200 1.000 40.78000  ? 86  LEU A HA   1 
ATOM   1304 H HB2  . LEU A 1 86  ? -9.04500  -19.18700 -11.32000 1.000 43.08000  ? 86  LEU A HB2  1 
ATOM   1305 H HB3  . LEU A 1 86  ? -9.91400  -18.83400 -10.04900 1.000 43.08000  ? 86  LEU A HB3  1 
ATOM   1306 H HG   . LEU A 1 86  ? -11.47400 -20.51500 -10.99500 1.000 49.47000  ? 86  LEU A HG   1 
ATOM   1307 H HD11 . LEU A 1 86  ? -10.61100 -22.09200 -12.31200 1.000 53.86000  ? 86  LEU A HD11 1 
ATOM   1308 H HD12 . LEU A 1 86  ? -10.03900 -20.75000 -12.94400 1.000 53.86000  ? 86  LEU A HD12 1 
ATOM   1309 H HD13 . LEU A 1 86  ? -9.11800  -21.63900 -12.00600 1.000 53.86000  ? 86  LEU A HD13 1 
ATOM   1310 H HD21 . LEU A 1 86  ? -10.42500 -22.16600 -9.68200  1.000 45.59000  ? 86  LEU A HD21 1 
ATOM   1311 H HD22 . LEU A 1 86  ? -9.14600  -21.22900 -9.57200  1.000 45.59000  ? 86  LEU A HD22 1 
ATOM   1312 H HD23 . LEU A 1 86  ? -10.52000 -20.77800 -8.91400  1.000 45.59000  ? 86  LEU A HD23 1 
ATOM   1313 N N    . ILE A 1 87  ? -11.46100 -15.82200 -11.35700 1.000 36.85000  ? 87  ILE A N    1 
ATOM   1314 C CA   . ILE A 1 87  ? -11.37800 -14.45600 -10.85600 1.000 37.86000  ? 87  ILE A CA   1 
ATOM   1315 C C    . ILE A 1 87  ? -11.80900 -14.43300 -9.39400  1.000 37.17000  ? 87  ILE A C    1 
ATOM   1316 O O    . ILE A 1 87  ? -12.83800 -15.01400 -9.02600  1.000 36.66000  ? 87  ILE A O    1 
ATOM   1317 C CB   . ILE A 1 87  ? -12.24600 -13.51300 -11.70600 1.000 39.83000  ? 87  ILE A CB   1 
ATOM   1318 C CG1  . ILE A 1 87  ? -11.69900 -13.42300 -13.13600 1.000 41.00000  ? 87  ILE A CG1  1 
ATOM   1319 C CG2  . ILE A 1 87  ? -12.34600 -12.14500 -11.03900 1.000 39.99000  ? 87  ILE A CG2  1 
ATOM   1320 C CD1  . ILE A 1 87  ? -10.31200 -12.84100 -13.24200 1.000 41.33000  ? 87  ILE A CD1  1 
ATOM   1321 H H    . ILE A 1 87  ? -12.20300 -16.00500 -11.75100 1.000 40.27000  ? 87  ILE A H    1 
ATOM   1322 H HA   . ILE A 1 87  ? -10.45900 -14.15500 -10.90500 1.000 47.26000  ? 87  ILE A HA   1 
ATOM   1323 H HB   . ILE A 1 87  ? -13.13900 -13.88800 -11.75100 1.000 51.25000  ? 87  ILE A HB   1 
ATOM   1324 H HG12 . ILE A 1 87  ? -11.68300 -14.31600 -13.51000 1.000 48.37000  ? 87  ILE A HG12 1 
ATOM   1325 H HG13 . ILE A 1 87  ? -12.29300 -12.86200 -13.65900 1.000 48.37000  ? 87  ILE A HG13 1 
ATOM   1326 H HG21 . ILE A 1 87  ? -12.60400 -11.48900 -11.70500 1.000 49.18000  ? 87  ILE A HG21 1 
ATOM   1327 H HG22 . ILE A 1 87  ? -13.01400 -12.18200 -10.33700 1.000 49.18000  ? 87  ILE A HG22 1 
ATOM   1328 H HG23 . ILE A 1 87  ? -11.48200 -11.91200 -10.66400 1.000 49.18000  ? 87  ILE A HG23 1 
ATOM   1329 H HD11 . ILE A 1 87  ? -10.27600 -12.24900 -14.00900 1.000 48.41000  ? 87  ILE A HD11 1 
ATOM   1330 H HD12 . ILE A 1 87  ? -10.10800 -12.34800 -12.43300 1.000 48.41000  ? 87  ILE A HD12 1 
ATOM   1331 H HD13 . ILE A 1 87  ? -9.67600  -13.56500 -13.35200 1.000 48.41000  ? 87  ILE A HD13 1 
ATOM   1332 N N    . LYS A 1 88  ? -11.01200 -13.77300 -8.55500  1.000 45.37000  ? 88  LYS A N    1 
ATOM   1333 C CA   . LYS A 1 88  ? -11.34600 -13.52400 -7.15800  1.000 45.09000  ? 88  LYS A CA   1 
ATOM   1334 C C    . LYS A 1 88  ? -11.38100 -12.01800 -6.94300  1.000 45.99000  ? 88  LYS A C    1 
ATOM   1335 O O    . LYS A 1 88  ? -10.41700 -11.32000 -7.27600  1.000 46.43000  ? 88  LYS A O    1 
ATOM   1336 C CB   . LYS A 1 88  ? -10.33300 -14.18100 -6.21200  1.000 44.77000  ? 88  LYS A CB   1 
ATOM   1337 C CG   . LYS A 1 88  ? -10.73600 -14.12200 -4.74200  1.000 45.07000  ? 88  LYS A CG   1 
ATOM   1338 C CD   . LYS A 1 88  ? -9.78000  -14.90200 -3.84300  1.000 44.88000  ? 88  LYS A CD   1 
ATOM   1339 C CE   . LYS A 1 88  ? -9.98300  -16.40600 -3.97600  1.000 45.40000  ? 88  LYS A CE   1 
ATOM   1340 N NZ   . LYS A 1 88  ? -9.93000  -17.09800 -2.65100  1.000 45.90000  ? 88  LYS A NZ   1 
ATOM   1341 H H    . LYS A 1 88  ? -10.24800 -13.45000 -8.78200  1.000 44.31000  ? 88  LYS A H    1 
ATOM   1342 H HA   . LYS A 1 88  ? -12.22600 -13.88300 -6.96400  1.000 46.22000  ? 88  LYS A HA   1 
ATOM   1343 H HB2  . LYS A 1 88  ? -10.23700 -15.11500 -6.45700  1.000 50.01000  ? 88  LYS A HB2  1 
ATOM   1344 H HB3  . LYS A 1 88  ? -9.48000  -13.72800 -6.30400  1.000 50.01000  ? 88  LYS A HB3  1 
ATOM   1345 H HG2  . LYS A 1 88  ? -10.73300 -13.19700 -4.45100  1.000 48.24000  ? 88  LYS A HG2  1 
ATOM   1346 H HG3  . LYS A 1 88  ? -11.62400 -14.49800 -4.64000  1.000 48.24000  ? 88  LYS A HG3  1 
ATOM   1347 H HD2  . LYS A 1 88  ? -8.86600  -14.69600 -4.09300  1.000 47.98000  ? 88  LYS A HD2  1 
ATOM   1348 H HD3  . LYS A 1 88  ? -9.93800  -14.65500 -2.91800  1.000 47.98000  ? 88  LYS A HD3  1 
ATOM   1349 H HE2  . LYS A 1 88  ? -10.85100 -16.57900 -4.37200  1.000 57.17000  ? 88  LYS A HE2  1 
ATOM   1350 H HE3  . LYS A 1 88  ? -9.28200  -16.77300 -4.53600  1.000 57.17000  ? 88  LYS A HE3  1 
ATOM   1351 H HZ1  . LYS A 1 88  ? -9.13800  -16.96100 -2.26800  1.000 48.79000  ? 88  LYS A HZ1  1 
ATOM   1352 H HZ2  . LYS A 1 88  ? -10.56800 -16.78200 -2.11700  1.000 48.79000  ? 88  LYS A HZ2  1 
ATOM   1353 H HZ3  . LYS A 1 88  ? -10.05100 -17.97300 -2.76000  1.000 48.79000  ? 88  LYS A HZ3  1 
ATOM   1354 N N    . ARG A 1 89  ? -12.48600 -11.51800 -6.40100  1.000 43.75000  ? 89  ARG A N    1 
ATOM   1355 C CA   . ARG A 1 89  ? -12.70200 -10.08700 -6.24700  1.000 44.62000  ? 89  ARG A CA   1 
ATOM   1356 C C    . ARG A 1 89  ? -12.35100 -9.63500  -4.83400  1.000 45.58000  ? 89  ARG A C    1 
ATOM   1357 O O    . ARG A 1 89  ? -12.23400 -10.43900 -3.90700  1.000 46.30000  ? 89  ARG A O    1 
ATOM   1358 C CB   . ARG A 1 89  ? -14.15400 -9.72500  -6.57300  1.000 45.94000  ? 89  ARG A CB   1 
ATOM   1359 C CG   . ARG A 1 89  ? -14.50000 -9.83100  -8.05300  1.000 45.53000  ? 89  ARG A CG   1 
ATOM   1360 C CD   . ARG A 1 89  ? -13.96800 -8.63200  -8.82300  1.000 46.99000  ? 89  ARG A CD   1 
ATOM   1361 N NE   . ARG A 1 89  ? -13.76400 -8.91000  -10.24100 1.000 47.67000  ? 89  ARG A NE   1 
ATOM   1362 C CZ   . ARG A 1 89  ? -14.69700 -8.78200  -11.17500 1.000 48.38000  ? 89  ARG A CZ   1 
ATOM   1363 N NH1  . ARG A 1 89  ? -15.93400 -8.42400  -10.87300 1.000 49.03000  ? 89  ARG A NH1  1 
ATOM   1364 N NH2  . ARG A 1 89  ? -14.38000 -9.01700  -12.44500 1.000 50.02000  ? 89  ARG A NH2  1 
ATOM   1365 H H    . ARG A 1 89  ? -13.13700 -11.99800 -6.10900  1.000 49.68000  ? 89  ARG A H    1 
ATOM   1366 H HA   . ARG A 1 89  ? -12.12600 -9.61100  -6.86500  1.000 45.96000  ? 89  ARG A HA   1 
ATOM   1367 H HB2  . ARG A 1 89  ? -14.74200 -10.32500 -6.08800  1.000 44.91000  ? 89  ARG A HB2  1 
ATOM   1368 H HB3  . ARG A 1 89  ? -14.31700 -8.81000  -6.29600  1.000 44.91000  ? 89  ARG A HB3  1 
ATOM   1369 H HG2  . ARG A 1 89  ? -14.09800 -10.63300 -8.42100  1.000 46.95000  ? 89  ARG A HG2  1 
ATOM   1370 H HG3  . ARG A 1 89  ? -15.46400 -9.85800  -8.15700  1.000 46.95000  ? 89  ARG A HG3  1 
ATOM   1371 H HD2  . ARG A 1 89  ? -14.59900 -7.90000  -8.74400  1.000 55.74000  ? 89  ARG A HD2  1 
ATOM   1372 H HD3  . ARG A 1 89  ? -13.11300 -8.37000  -8.44700  1.000 55.74000  ? 89  ARG A HD3  1 
ATOM   1373 H HE   . ARG A 1 89  ? -12.98400 -9.17500  -10.48800 1.000 53.12000  ? 89  ARG A HE   1 
ATOM   1374 H HH11 . ARG A 1 89  ? -16.15300 -8.26700  -10.05700 1.000 57.80000  ? 89  ARG A HH11 1 
ATOM   1375 H HH12 . ARG A 1 89  ? -16.52200 -8.34800  -11.49600 1.000 57.80000  ? 89  ARG A HH12 1 
ATOM   1376 H HH21 . ARG A 1 89  ? -13.57900 -9.25100  -12.65200 1.000 56.65000  ? 89  ARG A HH21 1 
ATOM   1377 H HH22 . ARG A 1 89  ? -14.97700 -8.94000  -13.05900 1.000 56.65000  ? 89  ARG A HH22 1 
ATOM   1378 N N    . SER A 1 90  ? -12.18000 -8.31800  -4.68500  1.000 38.41000  ? 90  SER A N    1 
ATOM   1379 C CA   . SER A 1 90  ? -11.78200 -7.76500  -3.39500  1.000 39.86000  ? 90  SER A CA   1 
ATOM   1380 C C    . SER A 1 90  ? -12.78100 -8.11700  -2.30300  1.000 41.74000  ? 90  SER A C    1 
ATOM   1381 O O    . SER A 1 90  ? -12.39700 -8.29200  -1.14100  1.000 42.67000  ? 90  SER A O    1 
ATOM   1382 C CB   . SER A 1 90  ? -11.63600 -6.24800  -3.49700  1.000 42.01000  ? 90  SER A CB   1 
ATOM   1383 O OG   . SER A 1 90  ? -12.87800 -5.64400  -3.81800  1.000 43.80000  ? 90  SER A OG   1 
ATOM   1384 H H    . SER A 1 90  ? -12.28700 -7.73400  -5.30700  1.000 45.27000  ? 90  SER A H    1 
ATOM   1385 H HA   . SER A 1 90  ? -10.92100 -8.13400  -3.14500  1.000 43.55000  ? 90  SER A HA   1 
ATOM   1386 H HB2  . SER A 1 90  ? -11.32700 -5.90200  -2.64500  1.000 50.32000  ? 90  SER A HB2  1 
ATOM   1387 H HB3  . SER A 1 90  ? -10.99300 -6.03800  -4.19300  1.000 50.32000  ? 90  SER A HB3  1 
ATOM   1388 H HG   . SER A 1 90  ? -12.78700 -4.81100  -3.87200  1.000 52.95000  ? 90  SER A HG   1 
ATOM   1389 N N    . THR A 1 91  ? -14.06400 -8.22000  -2.65300  1.000 41.95000  ? 91  THR A N    1 
ATOM   1390 C CA   . THR A 1 91  ? -15.07300 -8.56300  -1.66000  1.000 43.85000  ? 91  THR A CA   1 
ATOM   1391 C C    . THR A 1 91  ? -14.89200 -9.97500  -1.12600  1.000 43.35000  ? 91  THR A C    1 
ATOM   1392 O O    . THR A 1 91  ? -15.47500 -10.31400 -0.09000  1.000 45.41000  ? 91  THR A O    1 
ATOM   1393 C CB   . THR A 1 91  ? -16.47700 -8.43300  -2.25400  1.000 44.72000  ? 91  THR A CB   1 
ATOM   1394 O OG1  . THR A 1 91  ? -16.60600 -9.31500  -3.37800  1.000 43.80000  ? 91  THR A OG1  1 
ATOM   1395 C CG2  . THR A 1 91  ? -16.74900 -7.00500  -2.69500  1.000 46.89000  ? 91  THR A CG2  1 
ATOM   1396 H H    . THR A 1 91  ? -14.36900 -8.09800  -3.44800  1.000 46.73000  ? 91  THR A H    1 
ATOM   1397 H HA   . THR A 1 91  ? -15.00400 -7.94800  -0.91300  1.000 43.58000  ? 91  THR A HA   1 
ATOM   1398 H HB   . THR A 1 91  ? -17.13300 -8.67400  -1.58100  1.000 38.65000  ? 91  THR A HB   1 
ATOM   1399 H HG1  . THR A 1 91  ? -17.37500 -9.24800  -3.70900  1.000 53.41000  ? 91  THR A HG1  1 
ATOM   1400 H HG21 . THR A 1 91  ? -17.64100 -6.93900  -3.06900  1.000 50.25000  ? 91  THR A HG21 1 
ATOM   1401 H HG22 . THR A 1 91  ? -16.68100 -6.40500  -1.93600  1.000 50.25000  ? 91  THR A HG22 1 
ATOM   1402 H HG23 . THR A 1 91  ? -16.10500 -6.73600  -3.36800  1.000 50.25000  ? 91  THR A HG23 1 
ATOM   1403 N N    . GLY A 1 92  ? -14.10400 -10.80200 -1.80700  1.000 46.05000  ? 92  GLY A N    1 
ATOM   1404 C CA   . GLY A 1 92  ? -14.00700 -12.20800 -1.49000  1.000 45.41000  ? 92  GLY A CA   1 
ATOM   1405 C C    . GLY A 1 92  ? -14.91500 -13.09700 -2.30900  1.000 44.74000  ? 92  GLY A C    1 
ATOM   1406 O O    . GLY A 1 92  ? -14.85100 -14.32500 -2.16100  1.000 44.69000  ? 92  GLY A O    1 
ATOM   1407 H H    . GLY A 1 92  ? -13.61000 -10.56400 -2.46900  1.000 48.90000  ? 92  GLY A H    1 
ATOM   1408 H HA2  . GLY A 1 92  ? -13.09300 -12.50100 -1.63200  1.000 47.91000  ? 92  GLY A HA2  1 
ATOM   1409 H HA3  . GLY A 1 92  ? -14.22200 -12.34000 -0.55300  1.000 47.91000  ? 92  GLY A HA3  1 
ATOM   1410 N N    . GLU A 1 93  ? -15.75200 -12.52100 -3.16700  1.000 46.24000  ? 93  GLU A N    1 
ATOM   1411 C CA   . GLU A 1 93  ? -16.66200 -13.31200 -3.98300  1.000 46.39000  ? 93  GLU A CA   1 
ATOM   1412 C C    . GLU A 1 93  ? -15.89200 -14.04400 -5.07300  1.000 43.70000  ? 93  GLU A C    1 
ATOM   1413 O O    . GLU A 1 93  ? -14.92600 -13.51900 -5.63400  1.000 41.70000  ? 93  GLU A O    1 
ATOM   1414 C CB   . GLU A 1 93  ? -17.72300 -12.41100 -4.60800  1.000 47.70000  ? 93  GLU A CB   1 
ATOM   1415 C CG   . GLU A 1 93  ? -19.09400 -13.04500 -4.73500  1.000 49.83000  ? 93  GLU A CG   1 
ATOM   1416 C CD   . GLU A 1 93  ? -20.08300 -12.12500 -5.42000  1.000 51.57000  ? 93  GLU A CD   1 
ATOM   1417 O OE1  . GLU A 1 93  ? -20.72100 -11.30600 -4.72300  1.000 55.10000  ? 93  GLU A OE1  1 
ATOM   1418 O OE2  . GLU A 1 93  ? -20.20900 -12.20900 -6.66000  1.000 50.53000  ? 93  GLU A OE2  1 
ATOM   1419 H H    . GLU A 1 93  ? -15.81200 -11.67300 -3.29500  1.000 47.46000  ? 93  GLU A H    1 
ATOM   1420 H HA   . GLU A 1 93  ? -17.10700 -13.97000 -3.42600  1.000 49.53000  ? 93  GLU A HA   1 
ATOM   1421 H HB2  . GLU A 1 93  ? -17.81700 -11.61600 -4.06000  1.000 50.46000  ? 93  GLU A HB2  1 
ATOM   1422 H HB3  . GLU A 1 93  ? -17.43100 -12.16100 -5.49900  1.000 50.46000  ? 93  GLU A HB3  1 
ATOM   1423 H HG2  . GLU A 1 93  ? -19.02200 -13.85700 -5.26100  1.000 54.70000  ? 93  GLU A HG2  1 
ATOM   1424 H HG3  . GLU A 1 93  ? -19.43400 -13.24900 -3.85000  1.000 54.70000  ? 93  GLU A HG3  1 
ATOM   1425 N N    . LEU A 1 94  ? -16.33300 -15.26000 -5.38000  1.000 47.40000  ? 94  LEU A N    1 
ATOM   1426 C CA   . LEU A 1 94  ? -15.65100 -16.12900 -6.33000  1.000 45.52000  ? 94  LEU A CA   1 
ATOM   1427 C C    . LEU A 1 94  ? -16.40900 -16.11500 -7.65100  1.000 45.36000  ? 94  LEU A C    1 
ATOM   1428 O O    . LEU A 1 94  ? -17.60300 -16.43100 -7.68600  1.000 47.17000  ? 94  LEU A O    1 
ATOM   1429 C CB   . LEU A 1 94  ? -15.55300 -17.55100 -5.77900  1.000 46.06000  ? 94  LEU A CB   1 
ATOM   1430 C CG   . LEU A 1 94  ? -15.07000 -17.67600 -4.33300  1.000 46.69000  ? 94  LEU A CG   1 
ATOM   1431 C CD1  . LEU A 1 94  ? -14.92600 -19.14000 -3.94400  1.000 47.48000  ? 94  LEU A CD1  1 
ATOM   1432 C CD2  . LEU A 1 94  ? -13.75900 -16.92800 -4.14100  1.000 44.80000  ? 94  LEU A CD2  1 
ATOM   1433 H H    . LEU A 1 94  ? -17.04200 -15.61100 -5.04200  1.000 51.12000  ? 94  LEU A H    1 
ATOM   1434 H HA   . LEU A 1 94  ? -14.75300 -15.79800 -6.48800  1.000 51.63000  ? 94  LEU A HA   1 
ATOM   1435 H HB2  . LEU A 1 94  ? -16.43200 -17.95800 -5.82700  1.000 52.50000  ? 94  LEU A HB2  1 
ATOM   1436 H HB3  . LEU A 1 94  ? -14.93500 -18.05200 -6.33400  1.000 52.50000  ? 94  LEU A HB3  1 
ATOM   1437 H HG   . LEU A 1 94  ? -15.73000 -17.27600 -3.74600  1.000 49.80000  ? 94  LEU A HG   1 
ATOM   1438 H HD11 . LEU A 1 94  ? -14.58900 -19.19300 -3.03600  1.000 52.25000  ? 94  LEU A HD11 1 
ATOM   1439 H HD12 . LEU A 1 94  ? -15.79500 -19.56800 -4.00100  1.000 52.25000  ? 94  LEU A HD12 1 
ATOM   1440 H HD13 . LEU A 1 94  ? -14.30500 -19.56800 -4.55300  1.000 52.25000  ? 94  LEU A HD13 1 
ATOM   1441 H HD21 . LEU A 1 94  ? -13.40000 -17.14100 -3.26600  1.000 45.67000  ? 94  LEU A HD21 1 
ATOM   1442 H HD22 . LEU A 1 94  ? -13.13500 -17.20300 -4.83000  1.000 45.67000  ? 94  LEU A HD22 1 
ATOM   1443 H HD23 . LEU A 1 94  ? -13.92500 -15.97500 -4.20700  1.000 45.67000  ? 94  LEU A HD23 1 
ATOM   1444 N N    . MET A 1 95  ? -15.71900 -15.75600 -8.73300  1.000 55.65000  ? 95  MET A N    1 
ATOM   1445 C CA   . MET A 1 95  ? -16.34800 -15.59300 -10.04400 1.000 56.28000  ? 95  MET A CA   1 
ATOM   1446 C C    . MET A 1 95  ? -15.56100 -16.37600 -11.07800 1.000 56.55000  ? 95  MET A C    1 
ATOM   1447 O O    . MET A 1 95  ? -14.57100 -15.87900 -11.64300 1.000 57.18000  ? 95  MET A O    1 
ATOM   1448 C CB   . MET A 1 95  ? -16.44900 -14.11500 -10.42600 1.000 57.18000  ? 95  MET A CB   1 
ATOM   1449 C CG   . MET A 1 95  ? -17.30900 -13.84600 -11.66300 1.000 59.98000  ? 95  MET A CG   1 
ATOM   1450 S SD   . MET A 1 95  ? -16.95700 -12.28000 -12.50500 1.000 62.06000  ? 95  MET A SD   1 
ATOM   1451 C CE   . MET A 1 95  ? -17.77300 -11.07800 -11.45200 1.000 61.32000  ? 95  MET A CE   1 
ATOM   1452 H H    . MET A 1 95  ? -14.87300 -15.59900 -8.73400  1.000 49.27000  ? 95  MET A H    1 
ATOM   1453 H HA   . MET A 1 95  ? -17.25300 -15.93600 -10.00400 1.000 47.72000  ? 95  MET A HA   1 
ATOM   1454 H HB2  . MET A 1 95  ? -16.83900 -13.62700 -9.68400  1.000 49.10000  ? 95  MET A HB2  1 
ATOM   1455 H HB3  . MET A 1 95  ? -15.55800 -13.77800 -10.60700 1.000 49.10000  ? 95  MET A HB3  1 
ATOM   1456 H HG2  . MET A 1 95  ? -17.16700 -14.56000 -12.30300 1.000 65.58000  ? 95  MET A HG2  1 
ATOM   1457 H HG3  . MET A 1 95  ? -18.24100 -13.83100 -11.39400 1.000 65.58000  ? 95  MET A HG3  1 
ATOM   1458 H HE1  . MET A 1 95  ? -17.67200 -10.19600 -11.84300 1.000 69.55000  ? 95  MET A HE1  1 
ATOM   1459 H HE2  . MET A 1 95  ? -18.71400 -11.30500 -11.38500 1.000 69.55000  ? 95  MET A HE2  1 
ATOM   1460 H HE3  . MET A 1 95  ? -17.36400 -11.10000 -10.57300 1.000 69.55000  ? 95  MET A HE3  1 
ATOM   1461 N N    . PRO A 1 96  ? -15.95300 -17.62300 -11.35400 1.000 38.34000  ? 96  PRO A N    1 
ATOM   1462 C CA   . PRO A 1 96  ? -15.34500 -18.38200 -12.45400 1.000 38.85000  ? 96  PRO A CA   1 
ATOM   1463 C C    . PRO A 1 96  ? -15.99200 -18.02600 -13.78700 1.000 40.12000  ? 96  PRO A C    1 
ATOM   1464 O O    . PRO A 1 96  ? -17.21500 -18.10300 -13.93700 1.000 40.91000  ? 96  PRO A O    1 
ATOM   1465 C CB   . PRO A 1 96  ? -15.61200 -19.84100 -12.07200 1.000 39.11000  ? 96  PRO A CB   1 
ATOM   1466 C CG   . PRO A 1 96  ? -16.88500 -19.77800 -11.25300 1.000 39.37000  ? 96  PRO A CG   1 
ATOM   1467 C CD   . PRO A 1 96  ? -16.85800 -18.45100 -10.52800 1.000 38.21000  ? 96  PRO A CD   1 
ATOM   1468 H HA   . PRO A 1 96  ? -14.38900 -18.22300 -12.49700 1.000 47.86000  ? 96  PRO A HA   1 
ATOM   1469 H HB2  . PRO A 1 96  ? -15.74100 -20.37400 -12.87200 1.000 53.02000  ? 96  PRO A HB2  1 
ATOM   1470 H HB3  . PRO A 1 96  ? -14.87600 -20.18400 -11.54200 1.000 53.02000  ? 96  PRO A HB3  1 
ATOM   1471 H HG2  . PRO A 1 96  ? -17.65300 -19.82600 -11.84400 1.000 54.09000  ? 96  PRO A HG2  1 
ATOM   1472 H HG3  . PRO A 1 96  ? -16.89800 -20.51100 -10.61800 1.000 54.09000  ? 96  PRO A HG3  1 
ATOM   1473 H HD2  . PRO A 1 96  ? -17.74700 -18.06300 -10.50600 1.000 46.24000  ? 96  PRO A HD2  1 
ATOM   1474 H HD3  . PRO A 1 96  ? -16.49500 -18.56100 -9.63500  1.000 46.24000  ? 96  PRO A HD3  1 
ATOM   1475 N N    . LEU A 1 97  ? -15.16600 -17.64200 -14.75500 1.000 33.13000  ? 97  LEU A N    1 
ATOM   1476 C CA   . LEU A 1 97  ? -15.62700 -17.22000 -16.07100 1.000 35.24000  ? 97  LEU A CA   1 
ATOM   1477 C C    . LEU A 1 97  ? -15.08500 -18.16700 -17.13200 1.000 35.90000  ? 97  LEU A C    1 
ATOM   1478 O O    . LEU A 1 97  ? -13.89700 -18.50800 -17.11800 1.000 35.25000  ? 97  LEU A O    1 
ATOM   1479 C CB   . LEU A 1 97  ? -15.18100 -15.78800 -16.37700 1.000 36.02000  ? 97  LEU A CB   1 
ATOM   1480 C CG   . LEU A 1 97  ? -15.61700 -14.67100 -15.42600 1.000 35.56000  ? 97  LEU A CG   1 
ATOM   1481 C CD1  . LEU A 1 97  ? -14.88900 -13.37800 -15.77600 1.000 36.79000  ? 97  LEU A CD1  1 
ATOM   1482 C CD2  . LEU A 1 97  ? -17.12000 -14.47400 -15.48100 1.000 35.95000  ? 97  LEU A CD2  1 
ATOM   1483 H H    . LEU A 1 97  ? -14.31100 -17.61700 -14.67000 1.000 42.04000  ? 97  LEU A H    1 
ATOM   1484 H HA   . LEU A 1 97  ? -16.59600 -17.25000 -16.10100 1.000 45.91000  ? 97  LEU A HA   1 
ATOM   1485 H HB2  . LEU A 1 97  ? -14.21100 -15.77700 -16.39700 1.000 43.77000  ? 97  LEU A HB2  1 
ATOM   1486 H HB3  . LEU A 1 97  ? -15.51700 -15.55500 -17.25700 1.000 43.77000  ? 97  LEU A HB3  1 
ATOM   1487 H HG   . LEU A 1 97  ? -15.37800 -14.91500 -14.51800 1.000 42.46000  ? 97  LEU A HG   1 
ATOM   1488 H HD11 . LEU A 1 97  ? -15.17800 -12.67900 -15.16800 1.000 44.83000  ? 97  LEU A HD11 1 
ATOM   1489 H HD12 . LEU A 1 97  ? -13.93400 -13.52000 -15.68800 1.000 44.83000  ? 97  LEU A HD12 1 
ATOM   1490 H HD13 . LEU A 1 97  ? -15.10400 -13.13200 -16.68900 1.000 44.83000  ? 97  LEU A HD13 1 
ATOM   1491 H HD21 . LEU A 1 97  ? -17.36100 -13.72000 -14.92100 1.000 41.55000  ? 97  LEU A HD21 1 
ATOM   1492 H HD22 . LEU A 1 97  ? -17.38100 -14.30000 -16.39900 1.000 41.55000  ? 97  LEU A HD22 1 
ATOM   1493 H HD23 . LEU A 1 97  ? -17.55600 -15.27900 -15.16000 1.000 41.55000  ? 97  LEU A HD23 1 
ATOM   1494 N N    . ALA A 1 98  ? -15.95300 -18.57900 -18.05400 1.000 30.19000  ? 98  ALA A N    1 
ATOM   1495 C CA   . ALA A 1 98  ? -15.56600 -19.45000 -19.15300 1.000 31.07000  ? 98  ALA A CA   1 
ATOM   1496 C C    . ALA A 1 98  ? -15.06000 -18.61900 -20.32500 1.000 32.24000  ? 98  ALA A C    1 
ATOM   1497 O O    . ALA A 1 98  ? -15.57000 -17.52800 -20.59400 1.000 33.15000  ? 98  ALA A O    1 
ATOM   1498 C CB   . ALA A 1 98  ? -16.74700 -20.31300 -19.59600 1.000 31.47000  ? 98  ALA A CB   1 
ATOM   1499 H H    . ALA A 1 98  ? -16.78500 -18.36200 -18.06200 1.000 36.58000  ? 98  ALA A H    1 
ATOM   1500 H HA   . ALA A 1 98  ? -14.85100 -20.03700 -18.86300 1.000 40.22000  ? 98  ALA A HA   1 
ATOM   1501 H HB1  . ALA A 1 98  ? -16.46400 -20.88300 -20.32800 1.000 37.12000  ? 98  ALA A HB1  1 
ATOM   1502 H HB2  . ALA A 1 98  ? -17.03900 -20.85600 -18.84700 1.000 37.12000  ? 98  ALA A HB2  1 
ATOM   1503 H HB3  . ALA A 1 98  ? -17.46900 -19.73400 -19.88700 1.000 37.12000  ? 98  ALA A HB3  1 
ATOM   1504 N N    . ALA A 1 99  ? -14.05400 -19.14200 -21.02200 1.000 32.08000  ? 99  ALA A N    1 
ATOM   1505 C CA   . ALA A 1 99  ? -13.48400 -18.44800 -22.16900 1.000 32.46000  ? 99  ALA A CA   1 
ATOM   1506 C C    . ALA A 1 99  ? -12.85100 -19.45900 -23.11000 1.000 32.30000  ? 99  ALA A C    1 
ATOM   1507 O O    . ALA A 1 99  ? -12.06700 -20.30700 -22.67500 1.000 31.63000  ? 99  ALA A O    1 
ATOM   1508 C CB   . ALA A 1 99  ? -12.44200 -17.41500 -21.72600 1.000 32.17000  ? 99  ALA A CB   1 
ATOM   1509 H H    . ALA A 1 99  ? -13.68400 -19.89900 -20.84900 1.000 38.24000  ? 99  ALA A H    1 
ATOM   1510 H HA   . ALA A 1 99  ? -14.19000 -17.98600 -22.64500 1.000 36.17000  ? 99  ALA A HA   1 
ATOM   1511 H HB1  . ALA A 1 99  ? -12.08600 -16.97000 -22.51100 1.000 37.15000  ? 99  ALA A HB1  1 
ATOM   1512 H HB2  . ALA A 1 99  ? -12.86800 -16.76800 -21.14300 1.000 37.15000  ? 99  ALA A HB2  1 
ATOM   1513 H HB3  . ALA A 1 99  ? -11.72900 -17.87000 -21.25100 1.000 37.15000  ? 99  ALA A HB3  1 
ATOM   1514 N N    . ARG A 1 100 ? -13.19500 -19.36600 -24.39300 1.000 43.22000  ? 100 ARG A N    1 
ATOM   1515 C CA   . ARG A 1 100 ? -12.57600 -20.19200 -25.42100 1.000 42.80000  ? 100 ARG A CA   1 
ATOM   1516 C C    . ARG A 1 100 ? -11.29900 -19.51400 -25.89700 1.000 41.95000  ? 100 ARG A C    1 
ATOM   1517 O O    . ARG A 1 100 ? -11.31800 -18.33600 -26.27000 1.000 42.24000  ? 100 ARG A O    1 
ATOM   1518 C CB   . ARG A 1 100 ? -13.52200 -20.41300 -26.60000 1.000 43.71000  ? 100 ARG A CB   1 
ATOM   1519 C CG   . ARG A 1 100 ? -12.95500 -21.36800 -27.63600 1.000 44.27000  ? 100 ARG A CG   1 
ATOM   1520 C CD   . ARG A 1 100 ? -13.77000 -21.37700 -28.91300 1.000 45.05000  ? 100 ARG A CD   1 
ATOM   1521 N NE   . ARG A 1 100 ? -15.15500 -21.77500 -28.68800 1.000 46.42000  ? 100 ARG A NE   1 
ATOM   1522 C CZ   . ARG A 1 100 ? -15.54300 -23.01300 -28.41000 1.000 46.74000  ? 100 ARG A CZ   1 
ATOM   1523 N NH1  . ARG A 1 100 ? -14.66900 -23.99100 -28.24100 1.000 46.37000  ? 100 ARG A NH1  1 
ATOM   1524 N NH2  . ARG A 1 100 ? -16.84300 -23.27500 -28.29800 1.000 47.37000  ? 100 ARG A NH2  1 
ATOM   1525 H H    . ARG A 1 100 ? -13.79200 -18.82500 -24.69500 1.000 43.65000  ? 100 ARG A H    1 
ATOM   1526 H HA   . ARG A 1 100 ? -12.34400 -21.05600 -25.04900 1.000 39.90000  ? 100 ARG A HA   1 
ATOM   1527 H HB2  . ARG A 1 100 ? -14.35500 -20.78600 -26.27200 1.000 39.24000  ? 100 ARG A HB2  1 
ATOM   1528 H HB3  . ARG A 1 100 ? -13.68800 -19.56200 -27.03500 1.000 39.24000  ? 100 ARG A HB3  1 
ATOM   1529 H HG2  . ARG A 1 100 ? -12.05100 -21.10000 -27.86400 1.000 43.82000  ? 100 ARG A HG2  1 
ATOM   1530 H HG3  . ARG A 1 100 ? -12.95300 -22.26600 -27.27000 1.000 43.82000  ? 100 ARG A HG3  1 
ATOM   1531 H HD2  . ARG A 1 100 ? -13.77200 -20.48500 -29.29400 1.000 40.69000  ? 100 ARG A HD2  1 
ATOM   1532 H HD3  . ARG A 1 100 ? -13.37400 -22.00500 -29.53700 1.000 40.69000  ? 100 ARG A HD3  1 
ATOM   1533 H HE   . ARG A 1 100 ? -15.76100 -21.16700 -28.73900 1.000 47.78000  ? 100 ARG A HE   1 
ATOM   1534 H HH11 . ARG A 1 100 ? -13.82700 -23.83700 -28.31400 1.000 45.54000  ? 100 ARG A HH11 1 
ATOM   1535 H HH12 . ARG A 1 100 ? -14.94500 -24.78500 -28.06000 1.000 45.54000  ? 100 ARG A HH12 1 
ATOM   1536 H HH21 . ARG A 1 100 ? -17.41900 -22.64500 -28.40300 1.000 45.41000  ? 100 ARG A HH21 1 
ATOM   1537 H HH22 . ARG A 1 100 ? -17.10700 -24.07200 -28.11300 1.000 45.41000  ? 100 ARG A HH22 1 
ATOM   1538 N N    . MET A 1 101 ? -10.19500 -20.25400 -25.89000 1.000 36.58000  ? 101 MET A N    1 
ATOM   1539 C CA   . MET A 1 101 ? -8.89400  -19.67900 -26.20100 1.000 35.74000  ? 101 MET A CA   1 
ATOM   1540 C C    . MET A 1 101 ? -8.63300  -19.71200 -27.70000 1.000 36.54000  ? 101 MET A C    1 
ATOM   1541 O O    . MET A 1 101 ? -8.95500  -20.69000 -28.38100 1.000 37.18000  ? 101 MET A O    1 
ATOM   1542 C CB   . MET A 1 101 ? -7.78400  -20.42800 -25.46600 1.000 34.48000  ? 101 MET A CB   1 
ATOM   1543 C CG   . MET A 1 101 ? -7.97100  -20.47900 -23.96300 1.000 34.09000  ? 101 MET A CG   1 
ATOM   1544 S SD   . MET A 1 101 ? -8.35700  -18.87200 -23.23600 1.000 33.74000  ? 101 MET A SD   1 
ATOM   1545 C CE   . MET A 1 101 ? -6.95500  -17.89600 -23.77200 1.000 32.22000  ? 101 MET A CE   1 
ATOM   1546 H H    . MET A 1 101 ? -10.17400 -21.09400 -25.70800 1.000 39.90000  ? 101 MET A H    1 
ATOM   1547 H HA   . MET A 1 101 ? -8.88100  -18.75500 -25.90900 1.000 40.65000  ? 101 MET A HA   1 
ATOM   1548 H HB2  . MET A 1 101 ? -7.75600  -21.34100 -25.79100 1.000 37.20000  ? 101 MET A HB2  1 
ATOM   1549 H HB3  . MET A 1 101 ? -6.93800  -19.99000 -25.64600 1.000 37.20000  ? 101 MET A HB3  1 
ATOM   1550 H HG2  . MET A 1 101 ? -8.70200  -21.08200 -23.75800 1.000 37.20000  ? 101 MET A HG2  1 
ATOM   1551 H HG3  . MET A 1 101 ? -7.15200  -20.80200 -23.55500 1.000 37.20000  ? 101 MET A HG3  1 
ATOM   1552 H HE1  . MET A 1 101 ? -7.05700  -16.99000 -23.44000 1.000 33.43000  ? 101 MET A HE1  1 
ATOM   1553 H HE2  . MET A 1 101 ? -6.14300  -18.29000 -23.41700 1.000 33.43000  ? 101 MET A HE2  1 
ATOM   1554 H HE3  . MET A 1 101 ? -6.92400  -17.89200 -24.74100 1.000 33.43000  ? 101 MET A HE3  1 
ATOM   1555 N N    . GLY A 1 102 ? -8.03200  -18.63700 -28.20300 1.000 38.68000  ? 102 GLY A N    1 
ATOM   1556 C CA   . GLY A 1 102 ? -7.76100  -18.51800 -29.61900 1.000 39.06000  ? 102 GLY A CA   1 
ATOM   1557 C C    . GLY A 1 102 ? -6.28800  -18.47600 -29.96400 1.000 38.83000  ? 102 GLY A C    1 
ATOM   1558 O O    . GLY A 1 102 ? -5.53300  -19.39100 -29.62200 1.000 38.48000  ? 102 GLY A O    1 
ATOM   1559 H H    . GLY A 1 102 ? -7.77200  -17.96200 -27.73700 1.000 44.72000  ? 102 GLY A H    1 
ATOM   1560 H HA2  . GLY A 1 102 ? -8.16500  -19.26200 -30.08900 1.000 41.08000  ? 102 GLY A HA2  1 
ATOM   1561 H HA3  . GLY A 1 102 ? -8.16700  -17.70100 -29.94800 1.000 41.08000  ? 102 GLY A HA3  1 
ATOM   1562 N N    . THR A 1 103 ? -5.86600  -17.40800 -30.63700 1.000 44.82000  ? 103 THR A N    1 
ATOM   1563 C CA   . THR A 1 103 ? -4.53400  -17.35300 -31.22100 1.000 45.50000  ? 103 THR A CA   1 
ATOM   1564 C C    . THR A 1 103 ? -3.48100  -17.07900 -30.15500 1.000 43.72000  ? 103 THR A C    1 
ATOM   1565 O O    . THR A 1 103 ? -3.57700  -16.10100 -29.40700 1.000 43.03000  ? 103 THR A O    1 
ATOM   1566 C CB   . THR A 1 103 ? -4.47400  -16.27300 -32.30000 1.000 46.21000  ? 103 THR A CB   1 
ATOM   1567 O OG1  . THR A 1 103 ? -5.70800  -16.25800 -33.02800 1.000 47.73000  ? 103 THR A OG1  1 
ATOM   1568 C CG2  . THR A 1 103 ? -3.32600  -16.54300 -33.26000 1.000 47.81000  ? 103 THR A CG2  1 
ATOM   1569 H H    . THR A 1 103 ? -6.33600  -16.70000 -30.76900 1.000 45.89000  ? 103 THR A H    1 
ATOM   1570 H HA   . THR A 1 103 ? -4.33200  -18.20700 -31.63500 1.000 55.62000  ? 103 THR A HA   1 
ATOM   1571 H HB   . THR A 1 103 ? -4.33200  -15.40800 -31.88500 1.000 52.19000  ? 103 THR A HB   1 
ATOM   1572 H HG1  . THR A 1 103 ? -5.68300  -15.66600 -33.62400 1.000 57.87000  ? 103 THR A HG1  1 
ATOM   1573 H HG21 . THR A 1 103 ? -3.24800  -15.81600 -33.89700 1.000 59.20000  ? 103 THR A HG21 1 
ATOM   1574 H HG22 . THR A 1 103 ? -2.49600  -16.62000 -32.76500 1.000 59.20000  ? 103 THR A HG22 1 
ATOM   1575 H HG23 . THR A 1 103 ? -3.48400  -17.37000 -33.74100 1.000 59.20000  ? 103 THR A HG23 1 
ATOM   1576 N N    . HIS A 1 104 ? -2.47100  -17.94500 -30.10100 1.000 54.44000  ? 104 HIS A N    1 
ATOM   1577 C CA   . HIS A 1 104 ? -1.33400  -17.79600 -29.20200 1.000 53.02000  ? 104 HIS A CA   1 
ATOM   1578 C C    . HIS A 1 104 ? -0.18800  -17.14200 -29.96200 1.000 54.07000  ? 104 HIS A C    1 
ATOM   1579 O O    . HIS A 1 104 ? 0.19100   -17.60600 -31.04200 1.000 57.30000  ? 104 HIS A O    1 
ATOM   1580 C CB   . HIS A 1 104 ? -0.90000  -19.15400 -28.64800 1.000 52.57000  ? 104 HIS A CB   1 
ATOM   1581 C CG   . HIS A 1 104 ? 0.32200   -19.09500 -27.78400 1.000 51.59000  ? 104 HIS A CG   1 
ATOM   1582 N ND1  . HIS A 1 104 ? 0.39100   -18.32500 -26.64200 1.000 50.89000  ? 104 HIS A ND1  1 
ATOM   1583 C CD2  . HIS A 1 104 ? 1.52100   -19.71500 -27.89200 1.000 52.71000  ? 104 HIS A CD2  1 
ATOM   1584 C CE1  . HIS A 1 104 ? 1.58100   -18.47100 -26.08700 1.000 50.09000  ? 104 HIS A CE1  1 
ATOM   1585 N NE2  . HIS A 1 104 ? 2.28600   -19.30900 -26.82600 1.000 51.40000  ? 104 HIS A NE2  1 
ATOM   1586 H H    . HIS A 1 104 ? -2.42300  -18.64900 -30.59300 1.000 54.83000  ? 104 HIS A H    1 
ATOM   1587 H HA   . HIS A 1 104 ? -1.57900  -17.22300 -28.45800 1.000 50.83000  ? 104 HIS A HA   1 
ATOM   1588 H HB2  . HIS A 1 104 ? -1.62300  -19.51900 -28.11400 1.000 51.76000  ? 104 HIS A HB2  1 
ATOM   1589 H HB3  . HIS A 1 104 ? -0.70900  -19.74800 -29.39100 1.000 51.76000  ? 104 HIS A HB3  1 
ATOM   1590 H HD2  . HIS A 1 104 ? 1.77900   -20.30400 -28.56400 1.000 60.49000  ? 104 HIS A HD2  1 
ATOM   1591 H HE1  . HIS A 1 104 ? 1.87200   -18.05400 -25.30900 1.000 52.20000  ? 104 HIS A HE1  1 
ATOM   1592 H HE2  . HIS A 1 104 ? 3.09300   -19.56000 -26.66500 1.000 46.29000  ? 104 HIS A HE2  1 
ATOM   1593 N N    . ALA A 1 105 ? 0.35300   -16.06300 -29.40300 1.000 45.36000  ? 105 ALA A N    1 
ATOM   1594 C CA   . ALA A 1 105 ? 1.41900   -15.30300 -30.03600 1.000 47.34000  ? 105 ALA A CA   1 
ATOM   1595 C C    . ALA A 1 105 ? 2.64400   -15.27200 -29.13300 1.000 47.29000  ? 105 ALA A C    1 
ATOM   1596 O O    . ALA A 1 105 ? 2.53900   -15.41400 -27.91000 1.000 45.11000  ? 105 ALA A O    1 
ATOM   1597 C CB   . ALA A 1 105 ? 0.96500   -13.87300 -30.35100 1.000 48.17000  ? 105 ALA A CB   1 
ATOM   1598 H H    . ALA A 1 105 ? 0.11200   -15.74700 -28.64000 1.000 56.27000  ? 105 ALA A H    1 
ATOM   1599 H HA   . ALA A 1 105 ? 1.66900   -15.73100 -30.87000 1.000 57.11000  ? 105 ALA A HA   1 
ATOM   1600 H HB1  . ALA A 1 105 ? 1.69700   -13.39500 -30.77100 1.000 58.02000  ? 105 ALA A HB1  1 
ATOM   1601 H HB2  . ALA A 1 105 ? 0.20500   -13.90900 -30.95200 1.000 58.02000  ? 105 ALA A HB2  1 
ATOM   1602 H HB3  . ALA A 1 105 ? 0.71300   -13.43300 -29.52400 1.000 58.02000  ? 105 ALA A HB3  1 
ATOM   1603 N N    . THR A 1 106 ? 3.81200   -15.10500 -29.75400 1.000 52.08000  ? 106 THR A N    1 
ATOM   1604 C CA   . THR A 1 106 ? 5.07800   -15.03800 -29.03800 1.000 51.97000  ? 106 THR A CA   1 
ATOM   1605 C C    . THR A 1 106 ? 5.99400   -14.08200 -29.77900 1.000 54.62000  ? 106 THR A C    1 
ATOM   1606 O O    . THR A 1 106 ? 6.05200   -14.08600 -31.01100 1.000 57.41000  ? 106 THR A O    1 
ATOM   1607 C CB   . THR A 1 106 ? 5.75300   -16.41000 -28.90600 1.000 52.13000  ? 106 THR A CB   1 
ATOM   1608 O OG1  . THR A 1 106 ? 6.27300   -16.82300 -30.17600 1.000 55.77000  ? 106 THR A OG1  1 
ATOM   1609 C CG2  . THR A 1 106 ? 4.75000   -17.43100 -28.35400 1.000 49.98000  ? 106 THR A CG2  1 
ATOM   1610 H H    . THR A 1 106 ? 3.89500   -15.02700 -30.60600 1.000 70.16000  ? 106 THR A H    1 
ATOM   1611 H HA   . THR A 1 106 ? 4.92600   -14.68600 -28.14700 1.000 65.54000  ? 106 THR A HA   1 
ATOM   1612 H HB   . THR A 1 106 ? 6.48600   -16.34000 -28.27400 1.000 65.88000  ? 106 THR A HB   1 
ATOM   1613 H HG1  . THR A 1 106 ? 6.64300   -17.57400 -30.10500 1.000 75.43000  ? 106 THR A HG1  1 
ATOM   1614 H HG21 . THR A 1 106 ? 5.20700   -18.25900 -28.13700 1.000 68.10000  ? 106 THR A HG21 1 
ATOM   1615 H HG22 . THR A 1 106 ? 4.33100   -17.08300 -27.55100 1.000 68.10000  ? 106 THR A HG22 1 
ATOM   1616 H HG23 . THR A 1 106 ? 4.06400   -17.61400 -29.01400 1.000 68.10000  ? 106 THR A HG23 1 
ATOM   1617 N N    . MET A 1 107 ? 6.69900   -13.26400 -29.01600 1.000 63.48000  ? 107 MET A N    1 
ATOM   1618 C CA   . MET A 1 107 ? 7.61200   -12.27400 -29.55500 1.000 66.15000  ? 107 MET A CA   1 
ATOM   1619 C C    . MET A 1 107 ? 8.97100   -12.50700 -28.94100 1.000 67.25000  ? 107 MET A C    1 
ATOM   1620 O O    . MET A 1 107 ? 9.09500   -12.57400 -27.71500 1.000 66.00000  ? 107 MET A O    1 
ATOM   1621 C CB   . MET A 1 107 ? 7.15600   -10.86200 -29.22500 1.000 66.14000  ? 107 MET A CB   1 
ATOM   1622 C CG   . MET A 1 107 ? 8.24700   -9.80900  -29.31700 1.000 69.90000  ? 107 MET A CG   1 
ATOM   1623 S SD   . MET A 1 107 ? 7.70800   -8.26500  -28.55700 1.000 71.27000  ? 107 MET A SD   1 
ATOM   1624 C CE   . MET A 1 107 ? 6.02000   -8.16600  -29.15700 1.000 68.70000  ? 107 MET A CE   1 
ATOM   1625 H H    . MET A 1 107 ? 6.66400   -13.26400 -28.15700 1.000 67.23000  ? 107 MET A H    1 
ATOM   1626 H HA   . MET A 1 107 ? 7.66600   -12.36600 -30.51800 1.000 63.13000  ? 107 MET A HA   1 
ATOM   1627 H HB2  . MET A 1 107 ? 6.45600   -10.62300 -29.85200 1.000 63.31000  ? 107 MET A HB2  1 
ATOM   1628 H HB3  . MET A 1 107 ? 6.80600   -10.84900 -28.32000 1.000 63.31000  ? 107 MET A HB3  1 
ATOM   1629 H HG2  . MET A 1 107 ? 9.04600   -10.08300 -28.84400 1.000 73.19000  ? 107 MET A HG2  1 
ATOM   1630 H HG3  . MET A 1 107 ? 8.45000   -9.63600  -30.25000 1.000 73.19000  ? 107 MET A HG3  1 
ATOM   1631 H HE1  . MET A 1 107 ? 5.68200   -7.27000  -29.00000 1.000 79.19000  ? 107 MET A HE1  1 
ATOM   1632 H HE2  . MET A 1 107 ? 6.01100   -8.36000  -30.10700 1.000 79.19000  ? 107 MET A HE2  1 
ATOM   1633 H HE3  . MET A 1 107 ? 5.47500   -8.81200  -28.68200 1.000 79.19000  ? 107 MET A HE3  1 
ATOM   1634 N N    . LYS A 1 108 ? 10.00000  -12.53700 -29.75400 1.000 64.13000  ? 108 LYS A N    1 
ATOM   1635 C CA   . LYS A 1 108 ? 11.36300  -12.71400 -29.24100 1.000 66.13000  ? 108 LYS A CA   1 
ATOM   1636 C C    . LYS A 1 108 ? 12.22600  -11.47700 -29.44700 1.000 69.51000  ? 108 LYS A C    1 
ATOM   1637 O O    . LYS A 1 108 ? 12.12200  -10.87200 -30.52400 1.000 71.93000  ? 108 LYS A O    1 
ATOM   1638 C CB   . LYS A 1 108 ? 12.00000  -13.91200 -29.94200 1.000 67.99000  ? 108 LYS A CB   1 
ATOM   1639 C CG   . LYS A 1 108 ? 13.01000  -14.68200 -29.12100 1.000 69.45000  ? 108 LYS A CG   1 
ATOM   1640 C CD   . LYS A 1 108 ? 13.13400  -16.10700 -29.64000 1.000 69.86000  ? 108 LYS A CD   1 
ATOM   1641 C CE   . LYS A 1 108 ? 14.34100  -16.80700 -29.13700 1.000 72.76000  ? 108 LYS A CE   1 
ATOM   1642 N NZ   . LYS A 1 108 ? 14.03500  -17.53900 -27.90800 1.000 69.15000  ? 108 LYS A NZ   1 
ATOM   1643 H H    . LYS A 1 108 ? 9.95000   -12.45800 -30.60900 1.000 67.30000  ? 108 LYS A H    1 
ATOM   1644 H HA   . LYS A 1 108 ? 11.33200  -12.90300 -28.29100 1.000 74.53000  ? 108 LYS A HA   1 
ATOM   1645 H HB2  . LYS A 1 108 ? 11.29600  -14.53100 -30.19300 1.000 76.37000  ? 108 LYS A HB2  1 
ATOM   1646 H HB3  . LYS A 1 108 ? 12.45300  -13.59600 -30.73900 1.000 76.37000  ? 108 LYS A HB3  1 
ATOM   1647 H HG2  . LYS A 1 108 ? 13.87600  -14.25100 -29.18900 1.000 92.64000  ? 108 LYS A HG2  1 
ATOM   1648 H HG3  . LYS A 1 108 ? 12.72000  -14.71600 -28.19600 1.000 92.64000  ? 108 LYS A HG3  1 
ATOM   1649 H HD2  . LYS A 1 108 ? 12.35600  -16.61400 -29.36000 1.000 93.18000  ? 108 LYS A HD2  1 
ATOM   1650 H HD3  . LYS A 1 108 ? 13.18300  -16.08600 -30.60900 1.000 93.18000  ? 108 LYS A HD3  1 
ATOM   1651 H HE2  . LYS A 1 108 ? 14.64700  -17.44200 -29.80400 1.000 111.77000 ? 108 LYS A HE2  1 
ATOM   1652 H HE3  . LYS A 1 108 ? 15.03600  -16.15900 -28.94300 1.000 111.77000 ? 108 LYS A HE3  1 
ATOM   1653 H HZ1  . LYS A 1 108 ? 14.76400  -17.95600 -27.61300 1.000 109.85000 ? 108 LYS A HZ1  1 
ATOM   1654 H HZ2  . LYS A 1 108 ? 13.40000  -18.14300 -28.06400 1.000 109.85000 ? 108 LYS A HZ2  1 
ATOM   1655 H HZ3  . LYS A 1 108 ? 13.75100  -16.97500 -27.28100 1.000 109.85000 ? 108 LYS A HZ3  1 
ATOM   1656 N N    . ILE A 1 109 ? 13.13500  -11.26800 -28.50000 1.000 88.77000  ? 109 ILE A N    1 
ATOM   1657 C CA   . ILE A 1 109 ? 14.19300  -10.27800 -28.60700 1.000 92.73000  ? 109 ILE A CA   1 
ATOM   1658 C C    . ILE A 1 109 ? 15.37500  -10.79000 -27.79400 1.000 94.21000  ? 109 ILE A C    1 
ATOM   1659 O O    . ILE A 1 109 ? 15.24400  -11.09000 -26.60100 1.000 91.75000  ? 109 ILE A O    1 
ATOM   1660 C CB   . ILE A 1 109 ? 13.70800  -8.90100  -28.12800 1.000 92.07000  ? 109 ILE A CB   1 
ATOM   1661 C CG1  . ILE A 1 109 ? 12.25800  -8.69600  -28.58200 1.000 90.08000  ? 109 ILE A CG1  1 
ATOM   1662 C CG2  . ILE A 1 109 ? 14.57300  -7.81200  -28.70900 1.000 95.83000  ? 109 ILE A CG2  1 
ATOM   1663 C CD1  . ILE A 1 109 ? 11.63000  -7.40500  -28.17300 1.000 90.49000  ? 109 ILE A CD1  1 
ATOM   1664 H H    . ILE A 1 109 ? 13.15700  -11.70600 -27.76000 1.000 90.55000  ? 109 ILE A H    1 
ATOM   1665 H HA   . ILE A 1 109 ? 14.46800  -10.20100 -29.53400 1.000 96.18000  ? 109 ILE A HA   1 
ATOM   1666 H HB   . ILE A 1 109 ? 13.75000  -8.86400  -27.16000 1.000 91.52000  ? 109 ILE A HB   1 
ATOM   1667 H HG12 . ILE A 1 109 ? 12.21700  -8.74800  -29.54900 1.000 90.76000  ? 109 ILE A HG12 1 
ATOM   1668 H HG13 . ILE A 1 109 ? 11.70100  -9.37900  -28.18200 1.000 90.76000  ? 109 ILE A HG13 1 
ATOM   1669 H HG21 . ILE A 1 109 ? 14.10200  -7.39500  -29.44700 1.000 83.17000  ? 109 ILE A HG21 1 
ATOM   1670 H HG22 . ILE A 1 109 ? 14.75700  -7.15400  -28.02000 1.000 83.17000  ? 109 ILE A HG22 1 
ATOM   1671 H HG23 . ILE A 1 109 ? 15.40300  -8.20000  -29.02600 1.000 83.17000  ? 109 ILE A HG23 1 
ATOM   1672 H HD11 . ILE A 1 109 ? 10.68900  -7.42400  -28.40900 1.000 98.13000  ? 109 ILE A HD11 1 
ATOM   1673 H HD12 . ILE A 1 109 ? 11.72900  -7.29700  -27.21400 1.000 98.13000  ? 109 ILE A HD12 1 
ATOM   1674 H HD13 . ILE A 1 109 ? 12.07200  -6.67600  -28.63500 1.000 98.13000  ? 109 ILE A HD13 1 
ATOM   1675 N N    . GLN A 1 110 ? 16.48900  -11.07200 -28.46100 1.000 88.32000  ? 110 GLN A N    1 
ATOM   1676 C CA   . GLN A 1 110 ? 17.80300  -11.22200 -27.79500 1.000 89.84000  ? 110 GLN A CA   1 
ATOM   1677 C C    . GLN A 1 110 ? 17.84600  -12.54700 -27.02100 1.000 87.08000  ? 110 GLN A C    1 
ATOM   1678 O O    . GLN A 1 110 ? 18.38200  -12.58300 -25.89900 1.000 86.73000  ? 110 GLN A O    1 
ATOM   1679 C CB   . GLN A 1 110 ? 18.04200  -10.04800 -26.85200 1.000 90.28000  ? 110 GLN A CB   1 
ATOM   1680 C CG   . GLN A 1 110 ? 17.56900  -8.68400  -27.32700 1.000 91.04000  ? 110 GLN A CG   1 
ATOM   1681 C CD   . GLN A 1 110 ? 18.16500  -7.57000  -26.50100 1.000 93.76000  ? 110 GLN A CD   1 
ATOM   1682 O OE1  . GLN A 1 110 ? 17.96200  -7.50000  -25.28500 1.000 92.03000  ? 110 GLN A OE1  1 
ATOM   1683 N NE2  . GLN A 1 110 ? 18.92600  -6.70300  -27.15100 1.000 98.26000  ? 110 GLN A NE2  1 
ATOM   1684 H H    . GLN A 1 110 ? 16.52100  -11.18500 -29.31300 1.000 107.72000 ? 110 GLN A H    1 
ATOM   1685 H HA   . GLN A 1 110 ? 18.50700  -11.23100 -28.46200 1.000 109.10000 ? 110 GLN A HA   1 
ATOM   1686 H HB2  . GLN A 1 110 ? 17.58700  -10.23300 -26.01600 1.000 108.53000 ? 110 GLN A HB2  1 
ATOM   1687 H HB3  . GLN A 1 110 ? 18.99600  -9.98000  -26.68900 1.000 108.53000 ? 110 GLN A HB3  1 
ATOM   1688 H HG2  . GLN A 1 110 ? 17.82500  -8.55400  -28.25400 1.000 104.49000 ? 110 GLN A HG2  1 
ATOM   1689 H HG3  . GLN A 1 110 ? 16.60900  -8.62600  -27.22800 1.000 104.49000 ? 110 GLN A HG3  1 
ATOM   1690 H HE21 . GLN A 1 110 ? 19.29200  -6.05000  -26.72700 1.000 107.95000 ? 110 GLN A HE21 1 
ATOM   1691 H HE22 . GLN A 1 110 ? 19.04700  -6.78700  -27.99800 1.000 107.95000 ? 110 GLN A HE22 1 
ATOM   1692 N N    . GLY A 1 111 ? 17.26200  -13.59600 -27.57800 1.000 94.43000  ? 111 GLY A N    1 
ATOM   1693 C CA   . GLY A 1 111 ? 17.10800  -14.87400 -26.86100 1.000 91.86000  ? 111 GLY A CA   1 
ATOM   1694 C C    . GLY A 1 111 ? 15.84800  -14.94100 -25.97300 1.000 86.81000  ? 111 GLY A C    1 
ATOM   1695 O O    . GLY A 1 111 ? 15.46100  -16.06800 -25.64100 1.000 84.32000  ? 111 GLY A O    1 
ATOM   1696 H H    . GLY A 1 111 ? 16.94100  -13.60300 -28.37600 1.000 112.32000 ? 111 GLY A H    1 
ATOM   1697 H HA2  . GLY A 1 111 ? 17.06200  -15.59700 -27.50600 1.000 110.59000 ? 111 GLY A HA2  1 
ATOM   1698 H HA3  . GLY A 1 111 ? 17.88400  -15.01900 -26.29700 1.000 110.59000 ? 111 GLY A HA3  1 
ATOM   1699 N N    . ARG A 1 112 ? 15.21100  -13.80300 -25.65100 1.000 114.91000 ? 112 ARG A N    1 
ATOM   1700 C CA   . ARG A 1 112 ? 14.13500  -13.70500 -24.62200 1.000 111.48000 ? 112 ARG A CA   1 
ATOM   1701 C C    . ARG A 1 112 ? 12.72600  -13.63300 -25.25500 1.000 109.36000 ? 112 ARG A C    1 
ATOM   1702 O O    . ARG A 1 112 ? 12.38000  -12.58500 -25.81600 1.000 110.12000 ? 112 ARG A O    1 
ATOM   1703 C CB   . ARG A 1 112 ? 14.32600  -12.47300 -23.73200 1.000 112.09000 ? 112 ARG A CB   1 
ATOM   1704 C CG   . ARG A 1 112 ? 15.58500  -12.49700 -22.87800 1.000 113.72000 ? 112 ARG A CG   1 
ATOM   1705 C CD   . ARG A 1 112 ? 16.49700  -11.32000 -23.17800 1.000 115.71000 ? 112 ARG A CD   1 
ATOM   1706 N NE   . ARG A 1 112 ? 15.90900  -10.04000 -22.77000 1.000 116.79000 ? 112 ARG A NE   1 
ATOM   1707 C CZ   . ARG A 1 112 ? 16.52900  -9.13400  -22.02800 1.000 117.78000 ? 112 ARG A CZ   1 
ATOM   1708 N NH1  . ARG A 1 112 ? 17.76500  -9.34900  -21.62000 1.000 114.26000 ? 112 ARG A NH1  1 
ATOM   1709 N NH2  . ARG A 1 112 ? 15.91000  -8.01600  -21.69700 1.000 122.29000 ? 112 ARG A NH2  1 
ATOM   1710 H H    . ARG A 1 112 ? 15.38500  -13.04700 -26.02300 1.000 105.61000 ? 112 ARG A H    1 
ATOM   1711 H HA   . ARG A 1 112 ? 14.16900  -14.49200 -24.05600 1.000 109.24000 ? 112 ARG A HA   1 
ATOM   1712 H HB2  . ARG A 1 112 ? 14.36900  -11.68600 -24.29700 1.000 115.15000 ? 112 ARG A HB2  1 
ATOM   1713 H HB3  . ARG A 1 112 ? 13.56600  -12.40300 -23.13300 1.000 115.15000 ? 112 ARG A HB3  1 
ATOM   1714 H HG2  . ARG A 1 112 ? 15.33600  -12.45600 -21.94200 1.000 117.26000 ? 112 ARG A HG2  1 
ATOM   1715 H HG3  . ARG A 1 112 ? 16.07600  -13.31400 -23.05800 1.000 117.26000 ? 112 ARG A HG3  1 
ATOM   1716 H HD2  . ARG A 1 112 ? 17.33300  -11.46600 -22.71600 1.000 139.33000 ? 112 ARG A HD2  1 
ATOM   1717 H HD3  . ARG A 1 112 ? 16.65300  -11.28200 -24.13500 1.000 139.33000 ? 112 ARG A HD3  1 
ATOM   1718 H HE   . ARG A 1 112 ? 15.10800  -9.86600  -23.03000 1.000 130.04000 ? 112 ARG A HE   1 
ATOM   1719 H HH11 . ARG A 1 112 ? 18.16000  -8.75500  -21.14000 1.000 135.21000 ? 112 ARG A HH11 1 
ATOM   1720 H HH12 . ARG A 1 112 ? 18.18300  -10.06800 -21.82500 1.000 135.21000 ? 112 ARG A HH12 1 
ATOM   1721 H HH21 . ARG A 1 112 ? 16.31300  -7.42800  -21.21600 1.000 117.19000 ? 112 ARG A HH21 1 
ATOM   1722 H HH22 . ARG A 1 112 ? 15.10400  -7.87600  -21.96300 1.000 117.19000 ? 112 ARG A HH22 1 
ATOM   1723 N N    . THR A 1 113 ? 11.92200  -14.68400 -25.06800 1.000 73.83000  ? 113 THR A N    1 
ATOM   1724 C CA   . THR A 1 113 ? 10.56300  -14.85300 -25.56300 1.000 71.85000  ? 113 THR A CA   1 
ATOM   1725 C C    . THR A 1 113 ? 9.61100   -14.48400 -24.49700 1.000 67.88000  ? 113 THR A C    1 
ATOM   1726 O O    . THR A 1 113 ? 9.71100   -15.02500 -23.44100 1.000 66.52000  ? 113 THR A O    1 
ATOM   1727 C CB   . THR A 1 113 ? 10.41000  -16.29400 -25.98800 1.000 72.01000  ? 113 THR A CB   1 
ATOM   1728 O OG1  . THR A 1 113 ? 11.11100  -16.39600 -27.21800 1.000 75.96000  ? 113 THR A OG1  1 
ATOM   1729 C CG2  . THR A 1 113 ? 8.96500   -16.69100 -26.21900 1.000 71.76000  ? 113 THR A CG2  1 
ATOM   1730 H H    . THR A 1 113 ? 12.17600  -15.36900 -24.61400 1.000 89.87000  ? 113 THR A H    1 
ATOM   1731 H HA   . THR A 1 113 ? 10.41600  -14.28000 -26.33100 1.000 81.15000  ? 113 THR A HA   1 
ATOM   1732 H HB   . THR A 1 113 ? 10.80400  -16.88400 -25.32700 1.000 85.41000  ? 113 THR A HB   1 
ATOM   1733 H HG1  . THR A 1 113 ? 11.06400  -17.18200 -27.51100 1.000 98.45000  ? 113 THR A HG1  1 
ATOM   1734 H HG21 . THR A 1 113 ? 8.92700   -17.53000 -26.70400 1.000 86.12000  ? 113 THR A HG21 1 
ATOM   1735 H HG22 . THR A 1 113 ? 8.50800   -16.79900 -25.37000 1.000 86.12000  ? 113 THR A HG22 1 
ATOM   1736 H HG23 . THR A 1 113 ? 8.51300   -16.00800 -26.73900 1.000 86.12000  ? 113 THR A HG23 1 
ATOM   1737 N N    . VAL A 1 114 ? 8.74300   -13.54300 -24.81600 1.000 59.50000  ? 114 VAL A N    1 
ATOM   1738 C CA   . VAL A 1 114 ? 7.46400   -13.18100 -24.14500 1.000 56.46000  ? 114 VAL A CA   1 
ATOM   1739 C C    . VAL A 1 114 ? 6.29300   -13.82100 -24.88900 1.000 55.60000  ? 114 VAL A C    1 
ATOM   1740 O O    . VAL A 1 114 ? 6.42300   -14.00900 -26.06300 1.000 57.14000  ? 114 VAL A O    1 
ATOM   1741 C CB   . VAL A 1 114 ? 7.28300   -11.66500 -24.08900 1.000 56.97000  ? 114 VAL A CB   1 
ATOM   1742 C CG1  . VAL A 1 114 ? 8.49100   -10.98800 -23.46700 1.000 58.43000  ? 114 VAL A CG1  1 
ATOM   1743 C CG2  . VAL A 1 114 ? 6.95500   -11.07200 -25.45100 1.000 59.64000  ? 114 VAL A CG2  1 
ATOM   1744 H H    . VAL A 1 114 ? 8.87800   -13.03400 -25.49600 1.000 68.25000  ? 114 VAL A H    1 
ATOM   1745 H HA   . VAL A 1 114 ? 7.47100   -13.52100 -23.23700 1.000 63.26000  ? 114 VAL A HA   1 
ATOM   1746 H HB   . VAL A 1 114 ? 6.52700   -11.47700 -23.51100 1.000 62.43000  ? 114 VAL A HB   1 
ATOM   1747 H HG11 . VAL A 1 114 ? 8.30300   -10.04200 -23.36200 1.000 66.64000  ? 114 VAL A HG11 1 
ATOM   1748 H HG12 . VAL A 1 114 ? 8.66600   -11.38900 -22.60100 1.000 66.64000  ? 114 VAL A HG12 1 
ATOM   1749 H HG13 . VAL A 1 114 ? 9.25700   -11.11000 -24.04900 1.000 66.64000  ? 114 VAL A HG13 1 
ATOM   1750 H HG21 . VAL A 1 114 ? 7.10800   -10.11500 -25.42300 1.000 68.02000  ? 114 VAL A HG21 1 
ATOM   1751 H HG22 . VAL A 1 114 ? 7.52900   -11.47900 -26.11800 1.000 68.02000  ? 114 VAL A HG22 1 
ATOM   1752 H HG23 . VAL A 1 114 ? 6.02500   -11.25200 -25.66100 1.000 68.02000  ? 114 VAL A HG23 1 
ATOM   1753 N N    . GLY A 1 115 ? 5.19400   -14.13500 -24.19400 1.000 45.88000  ? 115 GLY A N    1 
ATOM   1754 C CA   . GLY A 1 115 ? 4.10100   -14.90800 -24.75400 1.000 44.40000  ? 115 GLY A CA   1 
ATOM   1755 C C    . GLY A 1 115 ? 2.75100   -14.40900 -24.29100 1.000 43.49000  ? 115 GLY A C    1 
ATOM   1756 O O    . GLY A 1 115 ? 2.62500   -13.74200 -23.25900 1.000 43.43000  ? 115 GLY A O    1 
ATOM   1757 H H    . GLY A 1 115 ? 5.06400   -13.90200 -23.37700 1.000 63.64000  ? 115 GLY A H    1 
ATOM   1758 H HA2  . GLY A 1 115 ? 4.13100   -14.85700 -25.72200 1.000 54.16000  ? 115 GLY A HA2  1 
ATOM   1759 H HA3  . GLY A 1 115 ? 4.19500   -15.83700 -24.49200 1.000 54.16000  ? 115 GLY A HA3  1 
ATOM   1760 N N    . GLY A 1 116 ? 1.73400   -14.74700 -25.07500 1.000 38.29000  ? 116 GLY A N    1 
ATOM   1761 C CA   . GLY A 1 116 ? 0.37100   -14.39200 -24.73500 1.000 38.39000  ? 116 GLY A CA   1 
ATOM   1762 C C    . GLY A 1 116 ? -0.60600  -15.14000 -25.60900 1.000 38.58000  ? 116 GLY A C    1 
ATOM   1763 O O    . GLY A 1 116 ? -0.24400  -15.67700 -26.66100 1.000 39.46000  ? 116 GLY A O    1 
ATOM   1764 H H    . GLY A 1 116 ? 1.81100   -15.18400 -25.81200 1.000 47.52000  ? 116 GLY A H    1 
ATOM   1765 H HA2  . GLY A 1 116 ? 0.19500   -14.61300 -23.80700 1.000 47.65000  ? 116 GLY A HA2  1 
ATOM   1766 H HA3  . GLY A 1 116 ? 0.23800   -13.43900 -24.86100 1.000 47.65000  ? 116 GLY A HA3  1 
ATOM   1767 N N    . GLN A 1 117 ? -1.85700  -15.17300 -25.15900 1.000 29.14000  ? 117 GLN A N    1 
ATOM   1768 C CA   . GLN A 1 117 ? -2.89800  -15.85100 -25.91400 1.000 29.72000  ? 117 GLN A CA   1 
ATOM   1769 C C    . GLN A 1 117 ? -4.22800  -15.15000 -25.69400 1.000 30.63000  ? 117 GLN A C    1 
ATOM   1770 O O    . GLN A 1 117 ? -4.54600  -14.73200 -24.57800 1.000 30.47000  ? 117 GLN A O    1 
ATOM   1771 C CB   . GLN A 1 117 ? -3.00900  -17.32800 -25.52100 1.000 28.96000  ? 117 GLN A CB   1 
ATOM   1772 C CG   . GLN A 1 117 ? -3.94400  -18.12900 -26.41600 1.000 29.83000  ? 117 GLN A CG   1 
ATOM   1773 C CD   . GLN A 1 117 ? -3.92100  -19.61600 -26.11300 1.000 29.91000  ? 117 GLN A CD   1 
ATOM   1774 O OE1  . GLN A 1 117 ? -3.46800  -20.04000 -25.05000 1.000 28.99000  ? 117 GLN A OE1  1 
ATOM   1775 N NE2  . GLN A 1 117 ? -4.40800  -20.41900 -27.05400 1.000 31.57000  ? 117 GLN A NE2  1 
ATOM   1776 H H    . GLN A 1 117 ? -2.12500  -14.81300 -24.42500 1.000 42.13000  ? 117 GLN A H    1 
ATOM   1777 H HA   . GLN A 1 117 ? -2.68700  -15.80600 -26.86000 1.000 41.12000  ? 117 GLN A HA   1 
ATOM   1778 H HB2  . GLN A 1 117 ? -2.12900  -17.73300 -25.57100 1.000 39.76000  ? 117 GLN A HB2  1 
ATOM   1779 H HB3  . GLN A 1 117 ? -3.34800  -17.38800 -24.61700 1.000 39.76000  ? 117 GLN A HB3  1 
ATOM   1780 H HG2  . GLN A 1 117 ? -4.85200  -17.81200 -26.28900 1.000 37.02000  ? 117 GLN A HG2  1 
ATOM   1781 H HG3  . GLN A 1 117 ? -3.67700  -18.00800 -27.34100 1.000 37.02000  ? 117 GLN A HG3  1 
ATOM   1782 H HE21 . GLN A 1 117 ? -4.71600  -20.08700 -27.78500 1.000 45.10000  ? 117 GLN A HE21 1 
ATOM   1783 H HE22 . GLN A 1 117 ? -4.41700  -21.27000 -26.93100 1.000 45.10000  ? 117 GLN A HE22 1 
ATOM   1784 N N    . MET A 1 118 ? -4.99600  -15.02900 -26.76900 1.000 43.02000  ? 118 MET A N    1 
ATOM   1785 C CA   . MET A 1 118 ? -6.28300  -14.35900 -26.73400 1.000 43.78000  ? 118 MET A CA   1 
ATOM   1786 C C    . MET A 1 118 ? -7.40000  -15.35800 -26.44400 1.000 43.50000  ? 118 MET A C    1 
ATOM   1787 O O    . MET A 1 118 ? -7.28800  -16.55400 -26.71800 1.000 43.34000  ? 118 MET A O    1 
ATOM   1788 C CB   . MET A 1 118 ? -6.55800  -13.65600 -28.06300 1.000 45.90000  ? 118 MET A CB   1 
ATOM   1789 C CG   . MET A 1 118 ? -5.90100  -12.29800 -28.25100 1.000 47.35000  ? 118 MET A CG   1 
ATOM   1790 S SD   . MET A 1 118 ? -6.99600  -11.19100 -29.18000 1.000 50.30000  ? 118 MET A SD   1 
ATOM   1791 C CE   . MET A 1 118 ? -7.63600  -12.27300 -30.46400 1.000 48.95000  ? 118 MET A CE   1 
ATOM   1792 H H    . MET A 1 118 ? -4.78700  -15.33400 -27.54500 1.000 44.84000  ? 118 MET A H    1 
ATOM   1793 H HA   . MET A 1 118 ? -6.27100  -13.68700 -26.03500 1.000 40.41000  ? 118 MET A HA   1 
ATOM   1794 H HB2  . MET A 1 118 ? -6.24600  -14.23100 -28.77900 1.000 50.59000  ? 118 MET A HB2  1 
ATOM   1795 H HB3  . MET A 1 118 ? -7.51600  -13.53000 -28.14100 1.000 50.59000  ? 118 MET A HB3  1 
ATOM   1796 H HG2  . MET A 1 118 ? -5.72500  -11.90000 -27.38400 1.000 61.32000  ? 118 MET A HG2  1 
ATOM   1797 H HG3  . MET A 1 118 ? -5.07600  -12.40400 -28.75000 1.000 61.32000  ? 118 MET A HG3  1 
ATOM   1798 H HE1  . MET A 1 118 ? -8.58800  -12.40100 -30.32900 1.000 55.28000  ? 118 MET A HE1  1 
ATOM   1799 H HE2  . MET A 1 118 ? -7.47300  -11.85000 -31.31800 1.000 55.28000  ? 118 MET A HE2  1 
ATOM   1800 H HE3  . MET A 1 118 ? -7.17800  -13.12500 -30.44600 1.000 55.28000  ? 118 MET A HE3  1 
ATOM   1801 N N    . GLY A 1 119 ? -8.49200  -14.84200 -25.88700 1.000 23.98000  ? 119 GLY A N    1 
ATOM   1802 C CA   . GLY A 1 119 ? -9.65100  -15.66300 -25.59400 1.000 24.10000  ? 119 GLY A CA   1 
ATOM   1803 C C    . GLY A 1 119 ? -10.92100 -14.84500 -25.67900 1.000 25.18000  ? 119 GLY A C    1 
ATOM   1804 O O    . GLY A 1 119 ? -10.89200 -13.61000 -25.68300 1.000 25.93000  ? 119 GLY A O    1 
ATOM   1805 H H    . GLY A 1 119 ? -8.58300  -14.01500 -25.67000 1.000 31.24000  ? 119 GLY A H    1 
ATOM   1806 H HA2  . GLY A 1 119 ? -9.70700  -16.39300 -26.23000 1.000 31.52000  ? 119 GLY A HA2  1 
ATOM   1807 H HA3  . GLY A 1 119 ? -9.57500  -16.03200 -24.70000 1.000 31.52000  ? 119 GLY A HA3  1 
ATOM   1808 N N    . MET A 1 120 ? -12.04500 -15.55500 -25.74600 1.000 47.34000  ? 120 MET A N    1 
ATOM   1809 C CA   . MET A 1 120 ? -13.36300 -14.93900 -25.85800 1.000 48.95000  ? 120 MET A CA   1 
ATOM   1810 C C    . MET A 1 120 ? -14.24500 -15.49700 -24.75300 1.000 49.19000  ? 120 MET A C    1 
ATOM   1811 O O    . MET A 1 120 ? -14.41900 -16.71500 -24.65100 1.000 48.75000  ? 120 MET A O    1 
ATOM   1812 C CB   . MET A 1 120 ? -13.98300 -15.21100 -27.23200 1.000 50.51000  ? 120 MET A CB   1 
ATOM   1813 C CG   . MET A 1 120 ? -14.76200 -14.03900 -27.81600 1.000 52.20000  ? 120 MET A CG   1 
ATOM   1814 S SD   . MET A 1 120 ? -13.70500 -12.67400 -28.35400 1.000 53.99000  ? 120 MET A SD   1 
ATOM   1815 C CE   . MET A 1 120 ? -12.75800 -13.46300 -29.65600 1.000 51.85000  ? 120 MET A CE   1 
ATOM   1816 H H    . MET A 1 120 ? -12.06900 -16.41400 -25.72800 1.000 35.72000  ? 120 MET A H    1 
ATOM   1817 H HA   . MET A 1 120 ? -13.28100 -13.97900 -25.74700 1.000 42.21000  ? 120 MET A HA   1 
ATOM   1818 H HB2  . MET A 1 120 ? -13.27400 -15.43900 -27.85300 1.000 53.10000  ? 120 MET A HB2  1 
ATOM   1819 H HB3  . MET A 1 120 ? -14.59600 -15.95800 -27.15100 1.000 53.10000  ? 120 MET A HB3  1 
ATOM   1820 H HG2  . MET A 1 120 ? -15.26400 -14.34800 -28.58600 1.000 61.83000  ? 120 MET A HG2  1 
ATOM   1821 H HG3  . MET A 1 120 ? -15.36900 -13.69800 -27.14100 1.000 61.83000  ? 120 MET A HG3  1 
ATOM   1822 H HE1  . MET A 1 120 ? -12.26500 -12.78300 -30.14200 1.000 59.47000  ? 120 MET A HE1  1 
ATOM   1823 H HE2  . MET A 1 120 ? -12.14100 -14.09800 -29.26000 1.000 59.47000  ? 120 MET A HE2  1 
ATOM   1824 H HE3  . MET A 1 120 ? -13.36700 -13.92100 -30.25600 1.000 59.47000  ? 120 MET A HE3  1 
ATOM   1825 N N    . LEU A 1 121 ? -14.79000 -14.60900 -23.92500 1.000 42.17000  ? 121 LEU A N    1 
ATOM   1826 C CA   . LEU A 1 121 ? -15.63400 -15.03400 -22.81700 1.000 42.48000  ? 121 LEU A CA   1 
ATOM   1827 C C    . LEU A 1 121 ? -16.93800 -15.62100 -23.34400 1.000 42.65000  ? 121 LEU A C    1 
ATOM   1828 O O    . LEU A 1 121 ? -17.57400 -15.05200 -24.23500 1.000 43.41000  ? 121 LEU A O    1 
ATOM   1829 C CB   . LEU A 1 121 ? -15.92100 -13.85300 -21.89200 1.000 42.63000  ? 121 LEU A CB   1 
ATOM   1830 C CG   . LEU A 1 121 ? -14.72400 -13.27600 -21.13400 1.000 41.60000  ? 121 LEU A CG   1 
ATOM   1831 C CD1  . LEU A 1 121 ? -15.01800 -11.85400 -20.67800 1.000 42.16000  ? 121 LEU A CD1  1 
ATOM   1832 C CD2  . LEU A 1 121 ? -14.37100 -14.16000 -19.94900 1.000 40.82000  ? 121 LEU A CD2  1 
ATOM   1833 H H    . LEU A 1 121 ? -14.68500 -13.75800 -23.98400 1.000 48.52000  ? 121 LEU A H    1 
ATOM   1834 H HA   . LEU A 1 121 ? -15.17400 -15.71900 -22.30600 1.000 52.19000  ? 121 LEU A HA   1 
ATOM   1835 H HB2  . LEU A 1 121 ? -16.29800 -13.13500 -22.42500 1.000 52.43000  ? 121 LEU A HB2  1 
ATOM   1836 H HB3  . LEU A 1 121 ? -16.57100 -14.13700 -21.23000 1.000 52.43000  ? 121 LEU A HB3  1 
ATOM   1837 H HG   . LEU A 1 121 ? -13.95700 -13.24900 -21.72700 1.000 44.26000  ? 121 LEU A HG   1 
ATOM   1838 H HD11 . LEU A 1 121 ? -14.25100 -11.51500 -20.19000 1.000 47.37000  ? 121 LEU A HD11 1 
ATOM   1839 H HD12 . LEU A 1 121 ? -15.18600 -11.30100 -21.45700 1.000 47.37000  ? 121 LEU A HD12 1 
ATOM   1840 H HD13 . LEU A 1 121 ? -15.79900 -11.86200 -20.10300 1.000 47.37000  ? 121 LEU A HD13 1 
ATOM   1841 H HD21 . LEU A 1 121 ? -13.59900 -13.78600 -19.49600 1.000 42.51000  ? 121 LEU A HD21 1 
ATOM   1842 H HD22 . LEU A 1 121 ? -15.12800 -14.19200 -19.34300 1.000 42.51000  ? 121 LEU A HD22 1 
ATOM   1843 H HD23 . LEU A 1 121 ? -14.16700 -15.05200 -20.27100 1.000 42.51000  ? 121 LEU A HD23 1 
ATOM   1844 N N    . LEU A 1 122 ? -17.33100 -16.76200 -22.79000 1.000 32.16000  ? 122 LEU A N    1 
ATOM   1845 C CA   . LEU A 1 122 ? -18.55300 -17.43700 -23.20300 1.000 31.71000  ? 122 LEU A CA   1 
ATOM   1846 C C    . LEU A 1 122 ? -19.66700 -17.20000 -22.18900 1.000 32.48000  ? 122 LEU A C    1 
ATOM   1847 O O    . LEU A 1 122 ? -20.51500 -16.32700 -22.37500 1.000 33.49000  ? 122 LEU A O    1 
ATOM   1848 C CB   . LEU A 1 122 ? -18.30200 -18.93400 -23.36600 1.000 31.32000  ? 122 LEU A CB   1 
ATOM   1849 C CG   . LEU A 1 122 ? -17.33100 -19.35300 -24.46700 1.000 31.36000  ? 122 LEU A CG   1 
ATOM   1850 C CD1  . LEU A 1 122 ? -16.83100 -20.76600 -24.21200 1.000 31.60000  ? 122 LEU A CD1  1 
ATOM   1851 C CD2  . LEU A 1 122 ? -18.00700 -19.25300 -25.82400 1.000 33.35000  ? 122 LEU A CD2  1 
ATOM   1852 H H    . LEU A 1 122 ? -16.90200 -17.16900 -22.16600 1.000 45.93000  ? 122 LEU A H    1 
ATOM   1853 H HA   . LEU A 1 122 ? -18.84300 -17.08500 -24.05900 1.000 35.02000  ? 122 LEU A HA   1 
ATOM   1854 H HB2  . LEU A 1 122 ? -17.95000 -19.27400 -22.52900 1.000 28.34000  ? 122 LEU A HB2  1 
ATOM   1855 H HB3  . LEU A 1 122 ? -19.15100 -19.36400 -23.55400 1.000 28.34000  ? 122 LEU A HB3  1 
ATOM   1856 H HG   . LEU A 1 122 ? -16.56700 -18.75500 -24.46400 1.000 32.64000  ? 122 LEU A HG   1 
ATOM   1857 H HD11 . LEU A 1 122 ? -16.24100 -21.02700 -24.93600 1.000 40.44000  ? 122 LEU A HD11 1 
ATOM   1858 H HD12 . LEU A 1 122 ? -16.35000 -20.78300 -23.37000 1.000 40.44000  ? 122 LEU A HD12 1 
ATOM   1859 H HD13 . LEU A 1 122 ? -17.59100 -21.36700 -24.17200 1.000 40.44000  ? 122 LEU A HD13 1 
ATOM   1860 H HD21 . LEU A 1 122 ? -17.37700 -19.52300 -26.51100 1.000 46.07000  ? 122 LEU A HD21 1 
ATOM   1861 H HD22 . LEU A 1 122 ? -18.78000 -19.83900 -25.83500 1.000 46.07000  ? 122 LEU A HD22 1 
ATOM   1862 H HD23 . LEU A 1 122 ? -18.28500 -18.33500 -25.97100 1.000 46.07000  ? 122 LEU A HD23 1 
ATOM   1863 N N    . GLY A 1 133 ? -17.89900 -8.82100  -16.51900 1.000 35.25000  ? 133 GLY A N    1 
ATOM   1864 C CA   . GLY A 1 133 ? -16.71400 -9.52300  -16.97500 1.000 35.41000  ? 133 GLY A CA   1 
ATOM   1865 C C    . GLY A 1 133 ? -15.50800 -9.29900  -16.08600 1.000 34.82000  ? 133 GLY A C    1 
ATOM   1866 O O    . GLY A 1 133 ? -15.58800 -9.45400  -14.86900 1.000 34.64000  ? 133 GLY A O    1 
ATOM   1867 H HA2  . GLY A 1 133 ? -16.89700 -10.47500 -17.00500 1.000 42.03000  ? 133 GLY A HA2  1 
ATOM   1868 H HA3  . GLY A 1 133 ? -16.49100 -9.22700  -17.87100 1.000 42.03000  ? 133 GLY A HA3  1 
ATOM   1869 N N    . THR A 1 134 ? -14.38400 -8.93500  -16.69600 1.000 33.50000  ? 134 THR A N    1 
ATOM   1870 C CA   . THR A 1 134 ? -13.14600 -8.68800  -15.97200 1.000 33.36000  ? 134 THR A CA   1 
ATOM   1871 C C    . THR A 1 134 ? -12.95200 -7.19200  -15.75300 1.000 33.37000  ? 134 THR A C    1 
ATOM   1872 O O    . THR A 1 134 ? -13.39100 -6.36600  -16.55700 1.000 34.18000  ? 134 THR A O    1 
ATOM   1873 C CB   . THR A 1 134 ? -11.94500 -9.26500  -16.72500 1.000 34.34000  ? 134 THR A CB   1 
ATOM   1874 O OG1  . THR A 1 134 ? -11.91200 -8.74700  -18.06200 1.000 35.09000  ? 134 THR A OG1  1 
ATOM   1875 C CG2  . THR A 1 134 ? -12.02800 -10.78400 -16.76800 1.000 33.72000  ? 134 THR A CG2  1 
ATOM   1876 H H    . THR A 1 134 ? -14.31400 -8.82300  -17.54600 1.000 44.69000  ? 134 THR A H    1 
ATOM   1877 H HA   . THR A 1 134 ? -13.19200 -9.11800  -15.10400 1.000 47.27000  ? 134 THR A HA   1 
ATOM   1878 H HB   . THR A 1 134 ? -11.12800 -9.01700  -16.26400 1.000 49.42000  ? 134 THR A HB   1 
ATOM   1879 H HG1  . THR A 1 134 ? -11.27100 -9.08700  -18.48500 1.000 47.15000  ? 134 THR A HG1  1 
ATOM   1880 H HG21 . THR A 1 134 ? -11.26000 -11.14500 -17.23800 1.000 45.60000  ? 134 THR A HG21 1 
ATOM   1881 H HG22 . THR A 1 134 ? -12.04200 -11.14100 -15.86600 1.000 45.60000  ? 134 THR A HG22 1 
ATOM   1882 H HG23 . THR A 1 134 ? -12.83600 -11.05900 -17.22800 1.000 45.60000  ? 134 THR A HG23 1 
ATOM   1883 N N    . THR A 1 135 ? -12.28100 -6.84900  -14.65300 1.000 42.79000  ? 135 THR A N    1 
ATOM   1884 C CA   . THR A 1 135 ? -12.11700 -5.45100  -14.27100 1.000 42.19000  ? 135 THR A CA   1 
ATOM   1885 C C    . THR A 1 135 ? -10.68000 -5.15500  -13.85500 1.000 42.12000  ? 135 THR A C    1 
ATOM   1886 O O    . THR A 1 135 ? -9.88300  -6.08200  -13.66800 1.000 42.34000  ? 135 THR A O    1 
ATOM   1887 C CB   . THR A 1 135 ? -13.07400 -5.09900  -13.13100 1.000 41.41000  ? 135 THR A CB   1 
ATOM   1888 O OG1  . THR A 1 135 ? -12.71500 -5.84700  -11.96200 1.000 40.71000  ? 135 THR A OG1  1 
ATOM   1889 C CG2  . THR A 1 135 ? -14.51300 -5.42200  -13.51300 1.000 41.94000  ? 135 THR A CG2  1 
ATOM   1890 H H    . THR A 1 135 ? -11.91200 -7.40700  -14.11300 1.000 52.37000  ? 135 THR A H    1 
ATOM   1891 H HA   . THR A 1 135 ? -12.33300 -4.88800  -15.03000 1.000 44.28000  ? 135 THR A HA   1 
ATOM   1892 H HB   . THR A 1 135 ? -13.02800 -4.15500  -12.93100 1.000 46.60000  ? 135 THR A HB   1 
ATOM   1893 H HG1  . THR A 1 135 ? -11.96400 -5.59800  -11.67900 1.000 53.80000  ? 135 THR A HG1  1 
ATOM   1894 H HG21 . THR A 1 135 ? -14.73800 -4.99100  -14.35200 1.000 51.58000  ? 135 THR A HG21 1 
ATOM   1895 H HG22 . THR A 1 135 ? -14.62400 -6.38100  -13.61100 1.000 51.58000  ? 135 THR A HG22 1 
ATOM   1896 H HG23 . THR A 1 135 ? -15.11700 -5.10500  -12.82300 1.000 51.58000  ? 135 THR A HG23 1 
ATOM   1897 N N    . PRO A 1 136 ? -10.31300 -3.87900  -13.68800 1.000 48.72000  ? 136 PRO A N    1 
ATOM   1898 C CA   . PRO A 1 136 ? -8.88800  -3.53900  -13.50500 1.000 49.61000  ? 136 PRO A CA   1 
ATOM   1899 C C    . PRO A 1 136 ? -8.20900  -4.20400  -12.31200 1.000 48.41000  ? 136 PRO A C    1 
ATOM   1900 O O    . PRO A 1 136 ? -6.97400  -4.15400  -12.22800 1.000 48.54000  ? 136 PRO A O    1 
ATOM   1901 C CB   . PRO A 1 136 ? -8.90700  -2.01000  -13.34500 1.000 49.31000  ? 136 PRO A CB   1 
ATOM   1902 C CG   . PRO A 1 136 ? -10.13500 -1.56800  -14.09400 1.000 49.53000  ? 136 PRO A CG   1 
ATOM   1903 C CD   . PRO A 1 136 ? -11.14700 -2.68400  -13.92700 1.000 49.34000  ? 136 PRO A CD   1 
ATOM   1904 H HA   . PRO A 1 136 ? -8.39300  -3.76200  -14.30900 1.000 57.10000  ? 136 PRO A HA   1 
ATOM   1905 H HB2  . PRO A 1 136 ? -8.97400  -1.77900  -12.40500 1.000 48.66000  ? 136 PRO A HB2  1 
ATOM   1906 H HB3  . PRO A 1 136 ? -8.10700  -1.62800  -13.73900 1.000 48.66000  ? 136 PRO A HB3  1 
ATOM   1907 H HG2  . PRO A 1 136 ? -10.47100 -0.74300  -13.70900 1.000 43.67000  ? 136 PRO A HG2  1 
ATOM   1908 H HG3  . PRO A 1 136 ? -9.91700  -1.44300  -15.03100 1.000 43.67000  ? 136 PRO A HG3  1 
ATOM   1909 H HD2  . PRO A 1 136 ? -11.70900 -2.50200  -13.15900 1.000 48.06000  ? 136 PRO A HD2  1 
ATOM   1910 H HD3  . PRO A 1 136 ? -11.67000 -2.78600  -14.73700 1.000 48.06000  ? 136 PRO A HD3  1 
ATOM   1911 N N    . GLY A 1 137 ? -8.94800  -4.81900  -11.40000 1.000 37.51000  ? 137 GLY A N    1 
ATOM   1912 C CA   . GLY A 1 137 ? -8.32700  -5.46300  -10.26200 1.000 35.89000  ? 137 GLY A CA   1 
ATOM   1913 C C    . GLY A 1 137 ? -8.02600  -6.93300  -10.44400 1.000 35.21000  ? 137 GLY A C    1 
ATOM   1914 O O    . GLY A 1 137 ? -7.58100  -7.58400  -9.49100  1.000 33.37000  ? 137 GLY A O    1 
ATOM   1915 H H    . GLY A 1 137 ? -9.80600  -4.87500  -11.41800 1.000 54.20000  ? 137 GLY A H    1 
ATOM   1916 H HA2  . GLY A 1 137 ? -7.49500  -5.01100  -10.05500 1.000 48.43000  ? 137 GLY A HA2  1 
ATOM   1917 H HA3  . GLY A 1 137 ? -8.91300  -5.37300  -9.49500  1.000 48.43000  ? 137 GLY A HA3  1 
ATOM   1918 N N    . ASP A 1 138 ? -8.23100  -7.47700  -11.64300 1.000 39.63000  ? 138 ASP A N    1 
ATOM   1919 C CA   . ASP A 1 138 ? -8.23100  -8.91700  -11.84900 1.000 38.24000  ? 138 ASP A CA   1 
ATOM   1920 C C    . ASP A 1 138 ? -6.91900  -9.46400  -12.39600 1.000 38.55000  ? 138 ASP A C    1 
ATOM   1921 O O    . ASP A 1 138 ? -6.78100  -10.68700 -12.50600 1.000 37.83000  ? 138 ASP A O    1 
ATOM   1922 C CB   . ASP A 1 138 ? -9.36200  -9.31000  -12.81000 1.000 39.05000  ? 138 ASP A CB   1 
ATOM   1923 C CG   . ASP A 1 138 ? -10.72200 -8.84200  -12.33600 1.000 39.00000  ? 138 ASP A CG   1 
ATOM   1924 O OD1  . ASP A 1 138 ? -10.85000 -8.47000  -11.15100 1.000 38.05000  ? 138 ASP A OD1  1 
ATOM   1925 O OD2  . ASP A 1 138 ? -11.66500 -8.84100  -13.15600 1.000 40.30000  ? 138 ASP A OD2  1 
ATOM   1926 H H    . ASP A 1 138 ? -8.37400  -7.02400  -12.36000 1.000 51.54000  ? 138 ASP A H    1 
ATOM   1927 H HA   . ASP A 1 138 ? -8.40100  -9.35300  -11.00000 1.000 42.50000  ? 138 ASP A HA   1 
ATOM   1928 H HB2  . ASP A 1 138 ? -9.19300  -8.90900  -13.67700 1.000 43.13000  ? 138 ASP A HB2  1 
ATOM   1929 H HB3  . ASP A 1 138 ? -9.38700  -10.27500 -12.89000 1.000 43.13000  ? 138 ASP A HB3  1 
ATOM   1930 N N    . CYS A 1 139 ? -5.96500  -8.60800  -12.74800 1.000 34.22000  ? 139 CYS A N    1 
ATOM   1931 C CA   . CYS A 1 139 ? -4.72000  -9.09300  -13.32800 1.000 34.70000  ? 139 CYS A CA   1 
ATOM   1932 C C    . CYS A 1 139 ? -3.99200  -9.99600  -12.33900 1.000 33.59000  ? 139 CYS A C    1 
ATOM   1933 O O    . CYS A 1 139 ? -3.82600  -9.65000  -11.16700 1.000 32.97000  ? 139 CYS A O    1 
ATOM   1934 C CB   . CYS A 1 139 ? -3.84200  -7.91300  -13.73700 1.000 36.18000  ? 139 CYS A CB   1 
ATOM   1935 S SG   . CYS A 1 139 ? -4.53700  -6.95200  -15.11400 1.000 38.06000  ? 139 CYS A SG   1 
ATOM   1936 H H    . CYS A 1 139 ? -6.01200  -7.75400  -12.66300 1.000 37.06000  ? 139 CYS A H    1 
ATOM   1937 H HA   . CYS A 1 139 ? -4.91900  -9.61200  -14.12300 1.000 38.83000  ? 139 CYS A HA   1 
ATOM   1938 H HB2  . CYS A 1 139 ? -3.74100  -7.31800  -12.97800 1.000 48.44000  ? 139 CYS A HB2  1 
ATOM   1939 H HB3  . CYS A 1 139 ? -2.97400  -8.24700  -14.01400 1.000 48.44000  ? 139 CYS A HB3  1 
ATOM   1940 N N    . GLY A 1 140 ? -3.57400  -11.16700 -12.81600 1.000 33.51000  ? 140 GLY A N    1 
ATOM   1941 C CA   . GLY A 1 140 ? -2.91300  -12.15800 -11.99200 1.000 31.83000  ? 140 GLY A CA   1 
ATOM   1942 C C    . GLY A 1 140 ? -3.73100  -13.40200 -11.72100 1.000 29.64000  ? 140 GLY A C    1 
ATOM   1943 O O    . GLY A 1 140 ? -3.16200  -14.41000 -11.28100 1.000 28.35000  ? 140 GLY A O    1 
ATOM   1944 H H    . GLY A 1 140 ? -3.66800  -11.41000 -13.63600 1.000 41.64000  ? 140 GLY A H    1 
ATOM   1945 H HA2  . GLY A 1 140 ? -2.09100  -12.43100 -12.42800 1.000 36.38000  ? 140 GLY A HA2  1 
ATOM   1946 H HA3  . GLY A 1 140 ? -2.68200  -11.76000 -11.13800 1.000 36.38000  ? 140 GLY A HA3  1 
ATOM   1947 N N    . CYS A 1 141 ? -5.04600  -13.37200 -11.97000 1.000 35.15000  ? 141 CYS A N    1 
ATOM   1948 C CA   . CYS A 1 141 ? -5.89300  -14.52900 -11.70900 1.000 33.58000  ? 141 CYS A CA   1 
ATOM   1949 C C    . CYS A 1 141 ? -5.67500  -15.59800 -12.77800 1.000 32.54000  ? 141 CYS A C    1 
ATOM   1950 O O    . CYS A 1 141 ? -5.48500  -15.27300 -13.95400 1.000 33.33000  ? 141 CYS A O    1 
ATOM   1951 C CB   . CYS A 1 141 ? -7.36200  -14.12100 -11.67500 1.000 33.86000  ? 141 CYS A CB   1 
ATOM   1952 S SG   . CYS A 1 141 ? -7.80000  -13.10800 -10.24700 1.000 33.74000  ? 141 CYS A SG   1 
ATOM   1953 H H    . CYS A 1 141 ? -5.46600  -12.69300 -12.28900 1.000 37.52000  ? 141 CYS A H    1 
ATOM   1954 H HA   . CYS A 1 141 ? -5.65800  -14.88800 -10.84100 1.000 40.13000  ? 141 CYS A HA   1 
ATOM   1955 H HB2  . CYS A 1 141 ? -7.56000  -13.60700 -12.47300 1.000 40.19000  ? 141 CYS A HB2  1 
ATOM   1956 H HB3  . CYS A 1 141 ? -7.90800  -14.92100 -11.65600 1.000 40.19000  ? 141 CYS A HB3  1 
ATOM   1957 H HG   . CYS A 1 141 ? -8.92400  -12.70600 -10.35700 1.000 39.13000  ? 141 CYS A HG   1 
ATOM   1958 N N    . PRO A 1 142 ? -5.71700  -16.87300 -12.40500 1.000 26.86000  ? 142 PRO A N    1 
ATOM   1959 C CA   . PRO A 1 142 ? -5.25000  -17.92600 -13.31300 1.000 26.38000  ? 142 PRO A CA   1 
ATOM   1960 C C    . PRO A 1 142 ? -6.29600  -18.36100 -14.33300 1.000 26.27000  ? 142 PRO A C    1 
ATOM   1961 O O    . PRO A 1 142 ? -7.50500  -18.23000 -14.13600 1.000 26.98000  ? 142 PRO A O    1 
ATOM   1962 C CB   . PRO A 1 142 ? -4.90100  -19.07600 -12.36000 1.000 25.58000  ? 142 PRO A CB   1 
ATOM   1963 C CG   . PRO A 1 142 ? -5.83900  -18.88600 -11.18700 1.000 26.06000  ? 142 PRO A CG   1 
ATOM   1964 C CD   . PRO A 1 142 ? -6.07800  -17.39500 -11.07100 1.000 26.72000  ? 142 PRO A CD   1 
ATOM   1965 H HA   . PRO A 1 142 ? -4.44800  -17.63900 -13.77700 1.000 41.68000  ? 142 PRO A HA   1 
ATOM   1966 H HB2  . PRO A 1 142 ? -5.06200  -19.92700 -12.79700 1.000 36.36000  ? 142 PRO A HB2  1 
ATOM   1967 H HB3  . PRO A 1 142 ? -3.97600  -19.00100 -12.07800 1.000 36.36000  ? 142 PRO A HB3  1 
ATOM   1968 H HG2  . PRO A 1 142 ? -6.67200  -19.35100 -11.36100 1.000 36.20000  ? 142 PRO A HG2  1 
ATOM   1969 H HG3  . PRO A 1 142 ? -5.42300  -19.22600 -10.38100 1.000 36.20000  ? 142 PRO A HG3  1 
ATOM   1970 H HD2  . PRO A 1 142 ? -7.01200  -17.21700 -10.88000 1.000 40.44000  ? 142 PRO A HD2  1 
ATOM   1971 H HD3  . PRO A 1 142 ? -5.49800  -17.01900 -10.39100 1.000 40.44000  ? 142 PRO A HD3  1 
ATOM   1972 N N    . TYR A 1 143 ? -5.78100  -18.86600 -15.45500 1.000 30.18000  ? 143 TYR A N    1 
ATOM   1973 C CA   . TYR A 1 143 ? -6.55000  -19.57100 -16.47700 1.000 31.51000  ? 143 TYR A CA   1 
ATOM   1974 C C    . TYR A 1 143 ? -6.25300  -21.06100 -16.34700 1.000 31.36000  ? 143 TYR A C    1 
ATOM   1975 O O    . TYR A 1 143 ? -5.08200  -21.45600 -16.39000 1.000 30.81000  ? 143 TYR A O    1 
ATOM   1976 C CB   . TYR A 1 143 ? -6.16000  -19.11400 -17.88700 1.000 32.11000  ? 143 TYR A CB   1 
ATOM   1977 C CG   . TYR A 1 143 ? -6.57600  -17.72000 -18.30600 1.000 32.48000  ? 143 TYR A CG   1 
ATOM   1978 C CD1  . TYR A 1 143 ? -5.91000  -16.59700 -17.83400 1.000 32.65000  ? 143 TYR A CD1  1 
ATOM   1979 C CD2  . TYR A 1 143 ? -7.60500  -17.53300 -19.21800 1.000 34.68000  ? 143 TYR A CD2  1 
ATOM   1980 C CE1  . TYR A 1 143 ? -6.27700  -15.32300 -18.24100 1.000 34.42000  ? 143 TYR A CE1  1 
ATOM   1981 C CE2  . TYR A 1 143 ? -7.98100  -16.26900 -19.62800 1.000 36.37000  ? 143 TYR A CE2  1 
ATOM   1982 C CZ   . TYR A 1 143 ? -7.31200  -15.16700 -19.14200 1.000 36.18000  ? 143 TYR A CZ   1 
ATOM   1983 O OH   . TYR A 1 143 ? -7.69100  -13.90600 -19.54500 1.000 38.02000  ? 143 TYR A OH   1 
ATOM   1984 H H    . TYR A 1 143 ? -4.94600  -18.80800 -15.65200 1.000 41.99000  ? 143 TYR A H    1 
ATOM   1985 H HA   . TYR A 1 143 ? -7.49900  -19.42200 -16.34500 1.000 44.83000  ? 143 TYR A HA   1 
ATOM   1986 H HB2  . TYR A 1 143 ? -5.19400  -19.15600 -17.96000 1.000 44.75000  ? 143 TYR A HB2  1 
ATOM   1987 H HB3  . TYR A 1 143 ? -6.55400  -19.73200 -18.52300 1.000 44.75000  ? 143 TYR A HB3  1 
ATOM   1988 H HD1  . TYR A 1 143 ? -5.21000  -16.70000 -17.23000 1.000 43.90000  ? 143 TYR A HD1  1 
ATOM   1989 H HD2  . TYR A 1 143 ? -8.05800  -18.27400 -19.55200 1.000 44.52000  ? 143 TYR A HD2  1 
ATOM   1990 H HE1  . TYR A 1 143 ? -5.82900  -14.58400 -17.91000 1.000 42.24000  ? 143 TYR A HE1  1 
ATOM   1991 H HE2  . TYR A 1 143 ? -8.67900  -16.16200 -20.23300 1.000 47.40000  ? 143 TYR A HE2  1 
ATOM   1992 H HH   . TYR A 1 143 ? -8.32600  -13.95900 -20.09200 1.000 39.59000  ? 143 TYR A HH   1 
ATOM   1993 N N    . ILE A 1 144 ? -7.28800  -21.89300 -16.20800 1.000 32.33000  ? 144 ILE A N    1 
ATOM   1994 C CA   . ILE A 1 144 ? -7.06400  -23.31500 -15.94200 1.000 34.30000  ? 144 ILE A CA   1 
ATOM   1995 C C    . ILE A 1 144 ? -8.12100  -24.16200 -16.64300 1.000 35.56000  ? 144 ILE A C    1 
ATOM   1996 O O    . ILE A 1 144 ? -9.27400  -23.75200 -16.79600 1.000 35.27000  ? 144 ILE A O    1 
ATOM   1997 C CB   . ILE A 1 144 ? -7.06400  -23.61700 -14.42000 1.000 34.00000  ? 144 ILE A CB   1 
ATOM   1998 C CG1  . ILE A 1 144 ? -6.37700  -22.49500 -13.63500 1.000 32.22000  ? 144 ILE A CG1  1 
ATOM   1999 C CG2  . ILE A 1 144 ? -6.37500  -24.94900 -14.13000 1.000 35.83000  ? 144 ILE A CG2  1 
ATOM   2000 C CD1  . ILE A 1 144 ? -6.24700  -22.76400 -12.14500 1.000 31.74000  ? 144 ILE A CD1  1 
ATOM   2001 H H    . ILE A 1 144 ? -8.11500  -21.66400 -16.26200 1.000 34.92000  ? 144 ILE A H    1 
ATOM   2002 H HA   . ILE A 1 144 ? -6.19800  -23.57100 -16.29600 1.000 44.89000  ? 144 ILE A HA   1 
ATOM   2003 H HB   . ILE A 1 144 ? -7.98500  -23.67900 -14.12100 1.000 48.03000  ? 144 ILE A HB   1 
ATOM   2004 H HG12 . ILE A 1 144 ? -5.48400  -22.36600 -13.99100 1.000 46.93000  ? 144 ILE A HG12 1 
ATOM   2005 H HG13 . ILE A 1 144 ? -6.89300  -21.68000 -13.73600 1.000 46.93000  ? 144 ILE A HG13 1 
ATOM   2006 H HG21 . ILE A 1 144 ? -6.53700  -25.19800 -13.20700 1.000 52.04000  ? 144 ILE A HG21 1 
ATOM   2007 H HG22 . ILE A 1 144 ? -6.73700  -25.62800 -14.72000 1.000 52.04000  ? 144 ILE A HG22 1 
ATOM   2008 H HG23 . ILE A 1 144 ? -5.42200  -24.85100 -14.28500 1.000 52.04000  ? 144 ILE A HG23 1 
ATOM   2009 H HD11 . ILE A 1 144 ? -6.05700  -21.92900 -11.69000 1.000 40.61000  ? 144 ILE A HD11 1 
ATOM   2010 H HD12 . ILE A 1 144 ? -7.08100  -23.13700 -11.81800 1.000 40.61000  ? 144 ILE A HD12 1 
ATOM   2011 H HD13 . ILE A 1 144 ? -5.52400  -23.39300 -11.99900 1.000 40.61000  ? 144 ILE A HD13 1 
ATOM   2012 N N    . TYR A 1 145 ? -7.71500  -25.36800 -17.04800 1.000 32.72000  ? 145 TYR A N    1 
ATOM   2013 C CA   . TYR A 1 145 ? -8.60900  -26.37100 -17.61700 1.000 34.27000  ? 145 TYR A CA   1 
ATOM   2014 C C    . TYR A 1 145 ? -8.09200  -27.74100 -17.19700 1.000 34.70000  ? 145 TYR A C    1 
ATOM   2015 O O    . TYR A 1 145 ? -6.89600  -27.91000 -16.94800 1.000 34.81000  ? 145 TYR A O    1 
ATOM   2016 C CB   . TYR A 1 145 ? -8.70000  -26.25500 -19.15100 1.000 35.23000  ? 145 TYR A CB   1 
ATOM   2017 C CG   . TYR A 1 145 ? -7.51900  -26.81500 -19.92300 1.000 35.47000  ? 145 TYR A CG   1 
ATOM   2018 C CD1  . TYR A 1 145 ? -6.37300  -26.05700 -20.12900 1.000 34.49000  ? 145 TYR A CD1  1 
ATOM   2019 C CD2  . TYR A 1 145 ? -7.56100  -28.09500 -20.46300 1.000 36.99000  ? 145 TYR A CD2  1 
ATOM   2020 C CE1  . TYR A 1 145 ? -5.29800  -26.56300 -20.83600 1.000 35.03000  ? 145 TYR A CE1  1 
ATOM   2021 C CE2  . TYR A 1 145 ? -6.49000  -28.60900 -21.17300 1.000 37.43000  ? 145 TYR A CE2  1 
ATOM   2022 C CZ   . TYR A 1 145 ? -5.36300  -27.83800 -21.35700 1.000 36.65000  ? 145 TYR A CZ   1 
ATOM   2023 O OH   . TYR A 1 145 ? -4.29300  -28.34300 -22.06300 1.000 37.09000  ? 145 TYR A OH   1 
ATOM   2024 H H    . TYR A 1 145 ? -6.89800  -25.63300 -17.00000 1.000 43.21000  ? 145 TYR A H    1 
ATOM   2025 H HA   . TYR A 1 145 ? -9.49900  -26.25400 -17.24900 1.000 46.13000  ? 145 TYR A HA   1 
ATOM   2026 H HB2  . TYR A 1 145 ? -9.49300  -26.72800 -19.44800 1.000 48.67000  ? 145 TYR A HB2  1 
ATOM   2027 H HB3  . TYR A 1 145 ? -8.77900  -25.31700 -19.37900 1.000 48.67000  ? 145 TYR A HB3  1 
ATOM   2028 H HD1  . TYR A 1 145 ? -6.32500  -25.19700 -19.77800 1.000 40.82000  ? 145 TYR A HD1  1 
ATOM   2029 H HD2  . TYR A 1 145 ? -8.32000  -28.61800 -20.34000 1.000 48.88000  ? 145 TYR A HD2  1 
ATOM   2030 H HE1  . TYR A 1 145 ? -4.53600  -26.04500 -20.96200 1.000 44.61000  ? 145 TYR A HE1  1 
ATOM   2031 H HE2  . TYR A 1 145 ? -6.53100  -29.46900 -21.52500 1.000 49.27000  ? 145 TYR A HE2  1 
ATOM   2032 H HH   . TYR A 1 145 ? -4.46300  -29.12400 -22.32300 1.000 52.80000  ? 145 TYR A HH   1 
ATOM   2033 N N    . LYS A 1 146 ? -8.97400  -28.74000 -17.13900 1.000 58.76000  ? 146 LYS A N    1 
ATOM   2034 C CA   . LYS A 1 146 ? -8.58700  -30.12900 -16.77000 1.000 60.58000  ? 146 LYS A CA   1 
ATOM   2035 C C    . LYS A 1 146 ? -8.27100  -30.95300 -18.02600 1.000 61.95000  ? 146 LYS A C    1 
ATOM   2036 O O    . LYS A 1 146 ? -9.01600  -30.83800 -19.00600 1.000 62.18000  ? 146 LYS A O    1 
ATOM   2037 C CB   . LYS A 1 146 ? -9.64000  -30.89000 -15.95500 1.000 61.62000  ? 146 LYS A CB   1 
ATOM   2038 C CG   . LYS A 1 146 ? -8.96700  -31.92500 -15.08300 1.000 63.17000  ? 146 LYS A CG   1 
ATOM   2039 C CD   . LYS A 1 146 ? -9.79700  -32.76300 -14.13000 1.000 64.98000  ? 146 LYS A CD   1 
ATOM   2040 C CE   . LYS A 1 146 ? -8.84300  -33.52900 -13.27200 1.000 65.15000  ? 146 LYS A CE   1 
ATOM   2041 N NZ   . LYS A 1 146 ? -9.47600  -34.06400 -12.06700 1.000 66.34000  ? 146 LYS A NZ   1 
ATOM   2042 H H    . LYS A 1 146 ? -9.81200  -28.65000 -17.30800 1.000 48.04000  ? 146 LYS A H    1 
ATOM   2043 H HA   . LYS A 1 146 ? -7.77800  -30.08900 -16.23700 1.000 53.61000  ? 146 LYS A HA   1 
ATOM   2044 H HB2  . LYS A 1 146 ? -10.12000 -30.27000 -15.38400 1.000 59.82000  ? 146 LYS A HB2  1 
ATOM   2045 H HB3  . LYS A 1 146 ? -10.25200 -31.34300 -16.55600 1.000 59.82000  ? 146 LYS A HB3  1 
ATOM   2046 H HG2  . LYS A 1 146 ? -8.50700  -32.54700 -15.66900 1.000 75.52000  ? 146 LYS A HG2  1 
ATOM   2047 H HG3  . LYS A 1 146 ? -8.30900  -31.46000 -14.54300 1.000 75.52000  ? 146 LYS A HG3  1 
ATOM   2048 H HD2  . LYS A 1 146 ? -10.34000 -32.18900 -13.56700 1.000 93.65000  ? 146 LYS A HD2  1 
ATOM   2049 H HD3  . LYS A 1 146 ? -10.34800 -33.38700 -14.62800 1.000 93.65000  ? 146 LYS A HD3  1 
ATOM   2050 H HE2  . LYS A 1 146 ? -8.48900  -34.27500 -13.78100 1.000 91.90000  ? 146 LYS A HE2  1 
ATOM   2051 H HE3  . LYS A 1 146 ? -8.12000  -32.94600 -12.99200 1.000 91.90000  ? 146 LYS A HE3  1 
ATOM   2052 H HZ1  . LYS A 1 146 ? -9.87100  -33.40800 -11.61400 1.000 102.65000 ? 146 LYS A HZ1  1 
ATOM   2053 H HZ2  . LYS A 1 146 ? -8.86400  -34.44800 -11.54700 1.000 102.65000 ? 146 LYS A HZ2  1 
ATOM   2054 H HZ3  . LYS A 1 146 ? -10.08800 -34.67000 -12.28900 1.000 102.65000 ? 146 LYS A HZ3  1 
ATOM   2055 N N    . ARG A 1 147 ? -7.18400  -31.71300 -18.00400 1.000 48.28000  ? 147 ARG A N    1 
ATOM   2056 C CA   . ARG A 1 147 ? -6.78900  -32.62200 -19.09800 1.000 48.93000  ? 147 ARG A CA   1 
ATOM   2057 C C    . ARG A 1 147 ? -6.48200  -33.98300 -18.47600 1.000 50.70000  ? 147 ARG A C    1 
ATOM   2058 O O    . ARG A 1 147 ? -5.38300  -34.15000 -17.92700 1.000 51.35000  ? 147 ARG A O    1 
ATOM   2059 C CB   . ARG A 1 147 ? -5.56400  -32.11700 -19.85900 1.000 48.40000  ? 147 ARG A CB   1 
ATOM   2060 C CG   . ARG A 1 147 ? -5.05100  -33.07000 -20.92500 1.000 49.25000  ? 147 ARG A CG   1 
ATOM   2061 C CD   . ARG A 1 147 ? -3.88200  -32.46200 -21.66200 1.000 49.40000  ? 147 ARG A CD   1 
ATOM   2062 N NE   . ARG A 1 147 ? -2.66500  -32.47200 -20.84600 1.000 47.76000  ? 147 ARG A NE   1 
ATOM   2063 C CZ   . ARG A 1 147 ? -1.68700  -31.58800 -20.94400 1.000 47.12000  ? 147 ARG A CZ   1 
ATOM   2064 N NH1  . ARG A 1 147 ? -1.68500  -30.71200 -21.92800 1.000 47.28000  ? 147 ARG A NH1  1 
ATOM   2065 N NH2  . ARG A 1 147 ? -0.71900  -31.57400 -20.05000 1.000 47.29000  ? 147 ARG A NH2  1 
ATOM   2066 H H    . ARG A 1 147 ? -6.63300  -31.72600 -17.34400 1.000 57.51000  ? 147 ARG A H    1 
ATOM   2067 H HA   . ARG A 1 147 ? -7.52400  -32.72300 -19.72300 1.000 53.18000  ? 147 ARG A HA   1 
ATOM   2068 H HB2  . ARG A 1 147 ? -5.79300  -31.28200 -20.29600 1.000 53.21000  ? 147 ARG A HB2  1 
ATOM   2069 H HB3  . ARG A 1 147 ? -4.84400  -31.96800 -19.22600 1.000 53.21000  ? 147 ARG A HB3  1 
ATOM   2070 H HG2  . ARG A 1 147 ? -4.75200  -33.89400 -20.51000 1.000 52.81000  ? 147 ARG A HG2  1 
ATOM   2071 H HG3  . ARG A 1 147 ? -5.75700  -33.25000 -21.56500 1.000 52.81000  ? 147 ARG A HG3  1 
ATOM   2072 H HD2  . ARG A 1 147 ? -3.71100  -32.97300 -22.46900 1.000 56.48000  ? 147 ARG A HD2  1 
ATOM   2073 H HD3  . ARG A 1 147 ? -4.09600  -31.54300 -21.88500 1.000 56.48000  ? 147 ARG A HD3  1 
ATOM   2074 H HE   . ARG A 1 147 ? -2.58100  -33.09700 -20.26200 1.000 54.74000  ? 147 ARG A HE   1 
ATOM   2075 H HH11 . ARG A 1 147 ? -2.31700  -30.71000 -22.51000 1.000 55.32000  ? 147 ARG A HH11 1 
ATOM   2076 H HH12 . ARG A 1 147 ? -1.04600  -30.14000 -21.99000 1.000 55.32000  ? 147 ARG A HH12 1 
ATOM   2077 H HH21 . ARG A 1 147 ? -0.71700  -32.14800 -19.40900 1.000 59.62000  ? 147 ARG A HH21 1 
ATOM   2078 H HH22 . ARG A 1 147 ? -0.07800  -31.00500 -20.11900 1.000 59.62000  ? 147 ARG A HH22 1 
ATOM   2079 N N    . GLY A 1 148 ? -7.42600  -34.91300 -18.56600 1.000 52.92000  ? 148 GLY A N    1 
ATOM   2080 C CA   . GLY A 1 148 ? -7.26300  -36.25100 -17.99000 1.000 53.96000  ? 148 GLY A CA   1 
ATOM   2081 C C    . GLY A 1 148 ? -7.48900  -36.18200 -16.50500 1.000 54.41000  ? 148 GLY A C    1 
ATOM   2082 O O    . GLY A 1 148 ? -8.52500  -35.61900 -16.11100 1.000 54.04000  ? 148 GLY A O    1 
ATOM   2083 H H    . GLY A 1 148 ? -8.18100  -34.79600 -18.96000 1.000 66.35000  ? 148 GLY A H    1 
ATOM   2084 H HA2  . GLY A 1 148 ? -7.90600  -36.86300 -18.38100 1.000 64.46000  ? 148 GLY A HA2  1 
ATOM   2085 H HA3  . GLY A 1 148 ? -6.36700  -36.58000 -18.16000 1.000 64.46000  ? 148 GLY A HA3  1 
ATOM   2086 N N    . ASN A 1 149 ? -6.55200  -36.70000 -15.70900 1.000 86.81000  ? 149 ASN A N    1 
ATOM   2087 C CA   . ASN A 1 149 ? -6.67800  -36.67500 -14.22200 1.000 87.44000  ? 149 ASN A CA   1 
ATOM   2088 C C    . ASN A 1 149 ? -5.76900  -35.58600 -13.64900 1.000 86.40000  ? 149 ASN A C    1 
ATOM   2089 O O    . ASN A 1 149 ? -5.46500  -35.66700 -12.43800 1.000 86.94000  ? 149 ASN A O    1 
ATOM   2090 C CB   . ASN A 1 149 ? -6.37200  -38.04300 -13.62400 1.000 90.76000  ? 149 ASN A CB   1 
ATOM   2091 C CG   . ASN A 1 149 ? -6.99500  -39.16200 -14.42400 1.000 94.05000  ? 149 ASN A CG   1 
ATOM   2092 O OD1  . ASN A 1 149 ? -6.27900  -39.96400 -15.03300 1.000 96.30000  ? 149 ASN A OD1  1 
ATOM   2093 N ND2  . ASN A 1 149 ? -8.31800  -39.22900 -14.44100 1.000 96.05000  ? 149 ASN A ND2  1 
ATOM   2094 H H    . ASN A 1 149 ? -5.83100  -37.07400 -15.99100 1.000 71.50000  ? 149 ASN A H    1 
ATOM   2095 H HA   . ASN A 1 149 ? -7.59200  -36.45000 -13.98900 1.000 80.30000  ? 149 ASN A HA   1 
ATOM   2096 H HB2  . ASN A 1 149 ? -5.41200  -38.17800 -13.61200 1.000 92.27000  ? 149 ASN A HB2  1 
ATOM   2097 H HB3  . ASN A 1 149 ? -6.72600  -38.08300 -12.72200 1.000 92.27000  ? 149 ASN A HB3  1 
ATOM   2098 H HD21 . ASN A 1 149 ? -8.78300  -38.65200 -14.00500 1.000 102.20000 ? 149 ASN A HD21 1 
ATOM   2099 H HD22 . ASN A 1 149 ? -8.71100  -39.85100 -14.88500 1.000 102.20000 ? 149 ASN A HD22 1 
ATOM   2100 N N    . ASP A 1 150 ? -5.35200  -34.61100 -14.46200 1.000 58.78000  ? 150 ASP A N    1 
ATOM   2101 C CA   . ASP A 1 150 ? -4.48400  -33.52200 -14.04900 1.000 57.58000  ? 150 ASP A CA   1 
ATOM   2102 C C    . ASP A 1 150 ? -5.13700  -32.18900 -14.39200 1.000 55.81000  ? 150 ASP A C    1 
ATOM   2103 O O    . ASP A 1 150 ? -6.03200  -32.11000 -15.23900 1.000 55.80000  ? 150 ASP A O    1 
ATOM   2104 C CB   . ASP A 1 150 ? -3.10800  -33.61900 -14.72400 1.000 57.73000  ? 150 ASP A CB   1 
ATOM   2105 C CG   . ASP A 1 150 ? -2.49000  -34.99800 -14.59400 1.000 59.69000  ? 150 ASP A CG   1 
ATOM   2106 O OD1  . ASP A 1 150 ? -2.88700  -35.90400 -15.35800 1.000 60.54000  ? 150 ASP A OD1  1 
ATOM   2107 O OD2  . ASP A 1 150 ? -1.61000  -35.17900 -13.72500 1.000 60.30000  ? 150 ASP A OD2  1 
ATOM   2108 H H    . ASP A 1 150 ? -5.57300  -34.56300 -15.29200 1.000 73.62000  ? 150 ASP A H    1 
ATOM   2109 H HA   . ASP A 1 150 ? -4.35500  -33.56000 -13.08800 1.000 69.08000  ? 150 ASP A HA   1 
ATOM   2110 H HB2  . ASP A 1 150 ? -3.20400  -33.42100 -15.66900 1.000 67.86000  ? 150 ASP A HB2  1 
ATOM   2111 H HB3  . ASP A 1 150 ? -2.50700  -32.98000 -14.31000 1.000 67.86000  ? 150 ASP A HB3  1 
ATOM   2112 N N    . TYR A 1 151 ? -4.68100  -31.13900 -13.71500 1.000 55.51000  ? 151 TYR A N    1 
ATOM   2113 C CA   . TYR A 1 151 ? -5.11400  -29.77500 -13.97800 1.000 53.72000  ? 151 TYR A CA   1 
ATOM   2114 C C    . TYR A 1 151 ? -3.96500  -28.99700 -14.60200 1.000 52.71000  ? 151 TYR A C    1 
ATOM   2115 O O    . TYR A 1 151 ? -2.81700  -29.10100 -14.15800 1.000 53.17000  ? 151 TYR A O    1 
ATOM   2116 C CB   . TYR A 1 151 ? -5.58400  -29.08900 -12.69600 1.000 52.76000  ? 151 TYR A CB   1 
ATOM   2117 C CG   . TYR A 1 151 ? -6.72700  -29.80700 -12.01900 1.000 53.85000  ? 151 TYR A CG   1 
ATOM   2118 C CD1  . TYR A 1 151 ? -8.03900  -29.61100 -12.43000 1.000 53.80000  ? 151 TYR A CD1  1 
ATOM   2119 C CD2  . TYR A 1 151 ? -6.49300  -30.68700 -10.97200 1.000 55.25000  ? 151 TYR A CD2  1 
ATOM   2120 C CE1  . TYR A 1 151 ? -9.08800  -30.27000 -11.81400 1.000 54.36000  ? 151 TYR A CE1  1 
ATOM   2121 C CE2  . TYR A 1 151 ? -7.53400  -31.35000 -10.35000 1.000 55.74000  ? 151 TYR A CE2  1 
ATOM   2122 C CZ   . TYR A 1 151 ? -8.82700  -31.13900 -10.77400 1.000 55.27000  ? 151 TYR A CZ   1 
ATOM   2123 O OH   . TYR A 1 151 ? -9.86100  -31.80100 -10.15200 1.000 56.61000  ? 151 TYR A OH   1 
ATOM   2124 H H    . TYR A 1 151 ? -4.10300  -31.19600 -13.08100 1.000 61.12000  ? 151 TYR A H    1 
ATOM   2125 H HA   . TYR A 1 151 ? -5.85300  -29.78400 -14.60600 1.000 58.40000  ? 151 TYR A HA   1 
ATOM   2126 H HB2  . TYR A 1 151 ? -4.84400  -29.05100 -12.07100 1.000 58.76000  ? 151 TYR A HB2  1 
ATOM   2127 H HB3  . TYR A 1 151 ? -5.88200  -28.19100 -12.91100 1.000 58.76000  ? 151 TYR A HB3  1 
ATOM   2128 H HD1  . TYR A 1 151 ? -8.21600  -29.02600 -13.13100 1.000 72.26000  ? 151 TYR A HD1  1 
ATOM   2129 H HD2  . TYR A 1 151 ? -5.62100  -30.83200 -10.68300 1.000 72.04000  ? 151 TYR A HD2  1 
ATOM   2130 H HE1  . TYR A 1 151 ? -9.96200  -30.12900 -12.09900 1.000 74.90000  ? 151 TYR A HE1  1 
ATOM   2131 H HE2  . TYR A 1 151 ? -7.36200  -31.93600 -9.64900  1.000 74.49000  ? 151 TYR A HE2  1 
ATOM   2132 H HH   . TYR A 1 151 ? -9.56100  -32.29400 -9.54100  1.000 88.14000  ? 151 TYR A HH   1 
ATOM   2133 N N    . VAL A 1 152 ? -4.27800  -28.22300 -15.63700 1.000 32.06000  ? 152 VAL A N    1 
ATOM   2134 C CA   . VAL A 1 152 ? -3.28100  -27.50300 -16.41700 1.000 31.67000  ? 152 VAL A CA   1 
ATOM   2135 C C    . VAL A 1 152 ? -3.59200  -26.01600 -16.33400 1.000 30.35000  ? 152 VAL A C    1 
ATOM   2136 O O    . VAL A 1 152 ? -4.69900  -25.58600 -16.68100 1.000 29.73000  ? 152 VAL A O    1 
ATOM   2137 C CB   . VAL A 1 152 ? -3.25400  -27.97400 -17.88000 1.000 32.06000  ? 152 VAL A CB   1 
ATOM   2138 C CG1  . VAL A 1 152 ? -2.30300  -27.11200 -18.69700 1.000 30.84000  ? 152 VAL A CG1  1 
ATOM   2139 C CG2  . VAL A 1 152 ? -2.86200  -29.44400 -17.95800 1.000 33.59000  ? 152 VAL A CG2  1 
ATOM   2140 H H    . VAL A 1 152 ? -5.08300  -28.09700 -15.91200 1.000 44.26000  ? 152 VAL A H    1 
ATOM   2141 H HA   . VAL A 1 152 ? -2.40200  -27.65100 -16.03500 1.000 45.86000  ? 152 VAL A HA   1 
ATOM   2142 H HB   . VAL A 1 152 ? -4.14200  -27.88100 -18.25800 1.000 46.74000  ? 152 VAL A HB   1 
ATOM   2143 H HG11 . VAL A 1 152 ? -2.10800  -27.56500 -19.53200 1.000 46.51000  ? 152 VAL A HG11 1 
ATOM   2144 H HG12 . VAL A 1 152 ? -2.72300  -26.25600 -18.87700 1.000 46.51000  ? 152 VAL A HG12 1 
ATOM   2145 H HG13 . VAL A 1 152 ? -1.48400  -26.98200 -18.19400 1.000 46.51000  ? 152 VAL A HG13 1 
ATOM   2146 H HG21 . VAL A 1 152 ? -2.83800  -29.71500 -18.88900 1.000 49.12000  ? 152 VAL A HG21 1 
ATOM   2147 H HG22 . VAL A 1 152 ? -1.98600  -29.55800 -17.55700 1.000 49.12000  ? 152 VAL A HG22 1 
ATOM   2148 H HG23 . VAL A 1 152 ? -3.51800  -29.97200 -17.47700 1.000 49.12000  ? 152 VAL A HG23 1 
ATOM   2149 N N    . VAL A 1 153 ? -2.61800  -25.23700 -15.87600 1.000 41.07000  ? 153 VAL A N    1 
ATOM   2150 C CA   . VAL A 1 153 ? -2.71300  -23.78300 -15.82800 1.000 37.87000  ? 153 VAL A CA   1 
ATOM   2151 C C    . VAL A 1 153 ? -1.90600  -23.22800 -16.99200 1.000 36.53000  ? 153 VAL A C    1 
ATOM   2152 O O    . VAL A 1 153 ? -0.73500  -23.58900 -17.17100 1.000 36.37000  ? 153 VAL A O    1 
ATOM   2153 C CB   . VAL A 1 153 ? -2.19800  -23.23400 -14.48700 1.000 35.95000  ? 153 VAL A CB   1 
ATOM   2154 C CG1  . VAL A 1 153 ? -0.77100  -23.70000 -14.24200 1.000 37.23000  ? 153 VAL A CG1  1 
ATOM   2155 C CG2  . VAL A 1 153 ? -2.28500  -21.71700 -14.47100 1.000 33.82000  ? 153 VAL A CG2  1 
ATOM   2156 H H    . VAL A 1 153 ? -1.87000  -25.54300 -15.58800 1.000 47.46000  ? 153 VAL A H    1 
ATOM   2157 H HA   . VAL A 1 153 ? -3.63800  -23.51200 -15.93700 1.000 45.19000  ? 153 VAL A HA   1 
ATOM   2158 H HB   . VAL A 1 153 ? -2.75400  -23.57600 -13.76900 1.000 41.80000  ? 153 VAL A HB   1 
ATOM   2159 H HG11 . VAL A 1 153 ? -0.48700  -23.37400 -13.37400 1.000 51.25000  ? 153 VAL A HG11 1 
ATOM   2160 H HG12 . VAL A 1 153 ? -0.73700  -24.66800 -14.25000 1.000 51.25000  ? 153 VAL A HG12 1 
ATOM   2161 H HG13 . VAL A 1 153 ? -0.19000  -23.33900 -14.92800 1.000 51.25000  ? 153 VAL A HG13 1 
ATOM   2162 H HG21 . VAL A 1 153 ? -2.13300  -21.40400 -13.56600 1.000 42.98000  ? 153 VAL A HG21 1 
ATOM   2163 H HG22 . VAL A 1 153 ? -1.60900  -21.35300 -15.06300 1.000 42.98000  ? 153 VAL A HG22 1 
ATOM   2164 H HG23 . VAL A 1 153 ? -3.16800  -21.44900 -14.76900 1.000 42.98000  ? 153 VAL A HG23 1 
ATOM   2165 N N    . ILE A 1 154 ? -2.52100  -22.35300 -17.78600 1.000 32.98000  ? 154 ILE A N    1 
ATOM   2166 C CA   . ILE A 1 154 ? -1.89400  -21.90100 -19.02200 1.000 32.12000  ? 154 ILE A CA   1 
ATOM   2167 C C    . ILE A 1 154 ? -1.36100  -20.47200 -18.94900 1.000 30.58000  ? 154 ILE A C    1 
ATOM   2168 O O    . ILE A 1 154 ? -0.54700  -20.08700 -19.80000 1.000 31.07000  ? 154 ILE A O    1 
ATOM   2169 C CB   . ILE A 1 154 ? -2.87000  -22.02500 -20.21100 1.000 33.23000  ? 154 ILE A CB   1 
ATOM   2170 C CG1  . ILE A 1 154 ? -4.06200  -21.08400 -20.01300 1.000 33.33000  ? 154 ILE A CG1  1 
ATOM   2171 C CG2  . ILE A 1 154 ? -3.34900  -23.46100 -20.37400 1.000 35.09000  ? 154 ILE A CG2  1 
ATOM   2172 C CD1  . ILE A 1 154 ? -4.99500  -21.00200 -21.20700 1.000 34.23000  ? 154 ILE A CD1  1 
ATOM   2173 H H    . ILE A 1 154 ? -3.29400  -22.01000 -17.63200 1.000 45.88000  ? 154 ILE A H    1 
ATOM   2174 H HA   . ILE A 1 154 ? -1.14200  -22.48000 -19.21200 1.000 39.62000  ? 154 ILE A HA   1 
ATOM   2175 H HB   . ILE A 1 154 ? -2.40300  -21.76300 -21.02000 1.000 37.19000  ? 154 ILE A HB   1 
ATOM   2176 H HG12 . ILE A 1 154 ? -4.58100  -21.39600 -19.25500 1.000 40.31000  ? 154 ILE A HG12 1 
ATOM   2177 H HG13 . ILE A 1 154 ? -3.74100  -20.18600 -19.84200 1.000 40.31000  ? 154 ILE A HG13 1 
ATOM   2178 H HG21 . ILE A 1 154 ? -3.85000  -23.53500 -21.19800 1.000 35.74000  ? 154 ILE A HG21 1 
ATOM   2179 H HG22 . ILE A 1 154 ? -2.57800  -24.04800 -20.40200 1.000 35.74000  ? 154 ILE A HG22 1 
ATOM   2180 H HG23 . ILE A 1 154 ? -3.91300  -23.69300 -19.62000 1.000 35.74000  ? 154 ILE A HG23 1 
ATOM   2181 H HD11 . ILE A 1 154 ? -5.66400  -20.32000 -21.03800 1.000 33.11000  ? 154 ILE A HD11 1 
ATOM   2182 H HD12 . ILE A 1 154 ? -4.47900  -20.77100 -21.99500 1.000 33.11000  ? 154 ILE A HD12 1 
ATOM   2183 H HD13 . ILE A 1 154 ? -5.42400  -21.86300 -21.33300 1.000 33.11000  ? 154 ILE A HD13 1 
ATOM   2184 N N    . GLY A 1 155 ? -1.78100  -19.67900 -17.94900 1.000 24.43000  ? 155 GLY A N    1 
ATOM   2185 C CA   . GLY A 1 155 ? -1.27000  -18.29900 -17.78000 1.000 24.36000  ? 155 GLY A CA   1 
ATOM   2186 C C    . GLY A 1 155 ? -2.02500  -17.49400 -16.73400 1.000 24.21000  ? 155 GLY A C    1 
ATOM   2187 O O    . GLY A 1 155 ? -2.78600  -18.11600 -15.97700 1.000 24.07000  ? 155 GLY A O    1 
ATOM   2188 H H    . GLY A 1 155 ? -2.35900  -19.91200 -17.35600 1.000 34.48000  ? 155 GLY A H    1 
ATOM   2189 H HA2  . GLY A 1 155 ? -0.33600  -18.33400 -17.52000 1.000 36.87000  ? 155 GLY A HA2  1 
ATOM   2190 H HA3  . GLY A 1 155 ? -1.33200  -17.83000 -18.62700 1.000 36.87000  ? 155 GLY A HA3  1 
ATOM   2191 N N    . VAL A 1 156 ? -1.76500  -16.18100 -16.62700 1.000 32.13000  ? 156 VAL A N    1 
ATOM   2192 C CA   . VAL A 1 156 ? -2.47200  -15.25800 -15.67800 1.000 34.00000  ? 156 VAL A CA   1 
ATOM   2193 C C    . VAL A 1 156 ? -3.00900  -14.07000 -16.49600 1.000 35.83000  ? 156 VAL A C    1 
ATOM   2194 O O    . VAL A 1 156 ? -2.24900  -13.58600 -17.34800 1.000 36.09000  ? 156 VAL A O    1 
ATOM   2195 C CB   . VAL A 1 156 ? -1.56700  -14.79000 -14.52100 1.000 34.86000  ? 156 VAL A CB   1 
ATOM   2196 C CG1  . VAL A 1 156 ? -0.96300  -15.96700 -13.76500 1.000 33.17000  ? 156 VAL A CG1  1 
ATOM   2197 C CG2  . VAL A 1 156 ? -0.46800  -13.84300 -14.98900 1.000 36.22000  ? 156 VAL A CG2  1 
ATOM   2198 H H    . VAL A 1 156 ? -1.17000  -15.78000 -17.10100 1.000 35.41000  ? 156 VAL A H    1 
ATOM   2199 H HA   . VAL A 1 156 ? -3.23100  -15.72300 -15.29300 1.000 41.07000  ? 156 VAL A HA   1 
ATOM   2200 H HB   . VAL A 1 156 ? -2.11600  -14.29900 -13.89000 1.000 38.61000  ? 156 VAL A HB   1 
ATOM   2201 H HG11 . VAL A 1 156 ? -0.44100  -15.62900 -13.02000 1.000 38.10000  ? 156 VAL A HG11 1 
ATOM   2202 H HG12 . VAL A 1 156 ? -1.68000  -16.53300 -13.43800 1.000 38.10000  ? 156 VAL A HG12 1 
ATOM   2203 H HG13 . VAL A 1 156 ? -0.39300  -16.47000 -14.36800 1.000 38.10000  ? 156 VAL A HG13 1 
ATOM   2204 H HG21 . VAL A 1 156 ? 0.20000   -13.76600 -14.29100 1.000 39.87000  ? 156 VAL A HG21 1 
ATOM   2205 H HG22 . VAL A 1 156 ? -0.06400  -14.20300 -15.79400 1.000 39.87000  ? 156 VAL A HG22 1 
ATOM   2206 H HG23 . VAL A 1 156 ? -0.85600  -12.97400 -15.17500 1.000 39.87000  ? 156 VAL A HG23 1 
ATOM   2207 N N    . HIS A 1 157 ? -4.23100  -13.58300 -16.24700 1.000 38.42000  ? 157 HIS A N    1 
ATOM   2208 C CA   . HIS A 1 157 ? -4.84500  -12.52800 -17.10600 1.000 40.68000  ? 157 HIS A CA   1 
ATOM   2209 C C    . HIS A 1 157 ? -4.03600  -11.23500 -17.05300 1.000 42.19000  ? 157 HIS A C    1 
ATOM   2210 O O    . HIS A 1 157 ? -3.66300  -10.82800 -15.93800 1.000 42.69000  ? 157 HIS A O    1 
ATOM   2211 C CB   . HIS A 1 157 ? -6.28000  -12.37300 -16.58800 1.000 41.39000  ? 157 HIS A CB   1 
ATOM   2212 C CG   . HIS A 1 157 ? -7.12000  -11.34000 -17.26400 1.000 43.93000  ? 157 HIS A CG   1 
ATOM   2213 N ND1  . HIS A 1 157 ? -6.74300  -10.01500 -17.26000 1.000 46.01000  ? 157 HIS A ND1  1 
ATOM   2214 C CD2  . HIS A 1 157 ? -8.28000  -11.39300 -17.93500 1.000 44.70000  ? 157 HIS A CD2  1 
ATOM   2215 C CE1  . HIS A 1 157 ? -7.66000  -9.29800  -17.88900 1.000 47.11000  ? 157 HIS A CE1  1 
ATOM   2216 N NE2  . HIS A 1 157 ? -8.60300  -10.11400 -18.30500 1.000 46.70000  ? 157 HIS A NE2  1 
ATOM   2217 H H    . HIS A 1 157 ? -4.73000  -13.83700 -15.59500 1.000 40.68000  ? 157 HIS A H    1 
ATOM   2218 H HA   . HIS A 1 157 ? -4.87600  -12.82900 -18.02700 1.000 40.69000  ? 157 HIS A HA   1 
ATOM   2219 H HB2  . HIS A 1 157 ? -6.73700  -13.22000 -16.67600 1.000 35.72000  ? 157 HIS A HB2  1 
ATOM   2220 H HB3  . HIS A 1 157 ? -6.23500  -12.13300 -15.64900 1.000 35.72000  ? 157 HIS A HB3  1 
ATOM   2221 H HD1  . HIS A 1 157 ? -6.03600  -9.69900  -16.88700 1.000 41.93000  ? 157 HIS A HD1  1 
ATOM   2222 H HD2  . HIS A 1 157 ? -8.78600  -12.15600 -18.09800 1.000 43.57000  ? 157 HIS A HD2  1 
ATOM   2223 H HE1  . HIS A 1 157 ? -7.63400  -8.37900  -18.02700 1.000 47.50000  ? 157 HIS A HE1  1 
ATOM   2224 N N    . THR A 1 158 ? -3.74500  -10.61800 -18.20400 1.000 42.29000  ? 158 THR A N    1 
ATOM   2225 C CA   . THR A 1 158 ? -3.06600  -9.30200  -18.25200 1.000 42.99000  ? 158 THR A CA   1 
ATOM   2226 C C    . THR A 1 158 ? -3.91300  -8.22600  -18.90600 1.000 44.25000  ? 158 THR A C    1 
ATOM   2227 O O    . THR A 1 158 ? -3.59500  -7.05500  -18.66900 1.000 44.41000  ? 158 THR A O    1 
ATOM   2228 C CB   . THR A 1 158 ? -1.73900  -9.48700  -18.98300 1.000 41.77000  ? 158 THR A CB   1 
ATOM   2229 O OG1  . THR A 1 158 ? -2.04100  -10.24600 -20.14900 1.000 41.46000  ? 158 THR A OG1  1 
ATOM   2230 C CG2  . THR A 1 158 ? -0.72900  -10.22200 -18.12300 1.000 41.19000  ? 158 THR A CG2  1 
ATOM   2231 H H    . THR A 1 158 ? -3.93000  -10.93900 -18.98000 1.000 45.74000  ? 158 THR A H    1 
ATOM   2232 H HA   . THR A 1 158 ? -2.86900  -9.01500  -17.34700 1.000 46.38000  ? 158 THR A HA   1 
ATOM   2233 H HB   . THR A 1 158 ? -1.37400  -8.62400  -19.23400 1.000 45.80000  ? 158 THR A HB   1 
ATOM   2234 H HG1  . THR A 1 158 ? -2.17100  -11.05000 -19.94500 1.000 50.38000  ? 158 THR A HG1  1 
ATOM   2235 H HG21 . THR A 1 158 ? 0.08800   -10.35400 -18.62000 1.000 52.62000  ? 158 THR A HG21 1 
ATOM   2236 H HG22 . THR A 1 158 ? -0.53400  -9.70600  -17.32600 1.000 52.62000  ? 158 THR A HG22 1 
ATOM   2237 H HG23 . THR A 1 158 ? -1.08300  -11.08600 -17.86100 1.000 52.62000  ? 158 THR A HG23 1 
ATOM   2238 N N    . ALA A 1 159 ? -4.93200  -8.56300  -19.70600 1.000 34.21000  ? 159 ALA A N    1 
ATOM   2239 C CA   . ALA A 1 159 ? -5.69200  -7.54400  -20.47800 1.000 35.81000  ? 159 ALA A CA   1 
ATOM   2240 C C    . ALA A 1 159 ? -7.09900  -8.01500  -20.84500 1.000 35.71000  ? 159 ALA A C    1 
ATOM   2241 O O    . ALA A 1 159 ? -7.34100  -9.22800  -20.76900 1.000 35.78000  ? 159 ALA A O    1 
ATOM   2242 C CB   . ALA A 1 159 ? -4.91300  -7.17300  -21.72100 1.000 35.57000  ? 159 ALA A CB   1 
ATOM   2243 H H    . ALA A 1 159 ? -5.20900  -9.36900  -19.82500 1.000 43.54000  ? 159 ALA A H    1 
ATOM   2244 H HA   . ALA A 1 159 ? -5.78100  -6.74500  -19.93500 1.000 48.66000  ? 159 ALA A HA   1 
ATOM   2245 H HB1  . ALA A 1 159 ? -5.42400  -6.52600  -22.23200 1.000 49.29000  ? 159 ALA A HB1  1 
ATOM   2246 H HB2  . ALA A 1 159 ? -4.06200  -6.78900  -21.45700 1.000 49.29000  ? 159 ALA A HB2  1 
ATOM   2247 H HB3  . ALA A 1 159 ? -4.76600  -7.97100  -22.25100 1.000 49.29000  ? 159 ALA A HB3  1 
ATOM   2248 N N    . ALA A 1 160 ? -8.00200  -7.09700  -21.20700 1.000 35.60000  ? 160 ALA A N    1 
ATOM   2249 C CA   . ALA A 1 160 ? -9.36500  -7.44500  -21.68300 1.000 36.79000  ? 160 ALA A CA   1 
ATOM   2250 C C    . ALA A 1 160 ? -9.91800  -6.27800  -22.50400 1.000 38.28000  ? 160 ALA A C    1 
ATOM   2251 O O    . ALA A 1 160 ? -9.83200  -5.13600  -22.00900 1.000 38.62000  ? 160 ALA A O    1 
ATOM   2252 C CB   . ALA A 1 160 ? -10.26300 -7.77400  -20.51800 1.000 36.16000  ? 160 ALA A CB   1 
ATOM   2253 H H    . ALA A 1 160 ? -7.85400  -6.25000  -21.18800 1.000 40.14000  ? 160 ALA A H    1 
ATOM   2254 H HA   . ALA A 1 160 ? -9.31400  -8.22400  -22.25900 1.000 50.68000  ? 160 ALA A HA   1 
ATOM   2255 H HB1  . ALA A 1 160 ? -9.84400  -8.46200  -19.97900 1.000 44.94000  ? 160 ALA A HB1  1 
ATOM   2256 H HB2  . ALA A 1 160 ? -10.39700 -6.97200  -19.99100 1.000 44.94000  ? 160 ALA A HB2  1 
ATOM   2257 H HB3  . ALA A 1 160 ? -11.11600 -8.08900  -20.85700 1.000 44.94000  ? 160 ALA A HB3  1 
ATOM   2258 N N    . ALA A 1 161 ? -10.47500 -6.53100  -23.69500 1.000 42.81000  ? 161 ALA A N    1 
ATOM   2259 C CA   . ALA A 1 161 ? -10.95700 -5.46900  -24.56700 1.000 43.48000  ? 161 ALA A CA   1 
ATOM   2260 C C    . ALA A 1 161 ? -12.06600 -4.68100  -23.88000 1.000 44.71000  ? 161 ALA A C    1 
ATOM   2261 O O    . ALA A 1 161 ? -12.83500 -5.21500  -23.07700 1.000 44.17000  ? 161 ALA A O    1 
ATOM   2262 C CB   . ALA A 1 161 ? -11.46400 -6.04500  -25.88800 1.000 43.89000  ? 161 ALA A CB   1 
ATOM   2263 H H    . ALA A 1 161 ? -10.58300 -7.32100  -24.01800 1.000 60.26000  ? 161 ALA A H    1 
ATOM   2264 H HA   . ALA A 1 161 ? -10.22800 -4.86000  -24.76200 1.000 59.19000  ? 161 ALA A HA   1 
ATOM   2265 H HB1  . ALA A 1 161 ? -12.19300 -6.65800  -25.70500 1.000 61.40000  ? 161 ALA A HB1  1 
ATOM   2266 H HB2  . ALA A 1 161 ? -11.77600 -5.31800  -26.45000 1.000 61.40000  ? 161 ALA A HB2  1 
ATOM   2267 H HB3  . ALA A 1 161 ? -10.73700 -6.51400  -26.32700 1.000 61.40000  ? 161 ALA A HB3  1 
ATOM   2268 N N    . ARG A 1 162 ? -12.14300 -3.39300  -24.20400 1.000 97.29000  ? 162 ARG A N    1 
ATOM   2269 C CA   . ARG A 1 162 ? -13.15100 -2.53200  -23.60100 1.000 97.62000  ? 162 ARG A CA   1 
ATOM   2270 C C    . ARG A 1 162 ? -14.53400 -2.91900  -24.10700 1.000 97.78000  ? 162 ARG A C    1 
ATOM   2271 O O    . ARG A 1 162 ? -14.81400 -2.83000  -25.30800 1.000 98.38000  ? 162 ARG A O    1 
ATOM   2272 C CB   . ARG A 1 162 ? -12.85700 -1.06600  -23.91300 1.000 99.48000  ? 162 ARG A CB   1 
ATOM   2273 C CG   . ARG A 1 162 ? -11.60800 -0.52600  -23.23600 1.000 102.99000 ? 162 ARG A CG   1 
ATOM   2274 C CD   . ARG A 1 162 ? -11.51700 0.98700   -23.37000 1.000 104.53000 ? 162 ARG A CD   1 
ATOM   2275 N NE   . ARG A 1 162 ? -11.44700 1.41600   -24.76200 1.000 105.54000 ? 162 ARG A NE   1 
ATOM   2276 C CZ   . ARG A 1 162 ? -10.32000 1.54000   -25.45100 1.000 106.35000 ? 162 ARG A CZ   1 
ATOM   2277 N NH1  . ARG A 1 162 ? -9.14500  1.25800   -24.91200 1.000 107.00000 ? 162 ARG A NH1  1 
ATOM   2278 N NH2  . ARG A 1 162 ? -10.37400 1.95900   -26.71200 1.000 107.60000 ? 162 ARG A NH2  1 
ATOM   2279 H H    . ARG A 1 162 ? -11.62700 -2.99700  -24.76600 1.000 82.09000  ? 162 ARG A H    1 
ATOM   2280 H HA   . ARG A 1 162 ? -13.13600 -2.64700  -22.63800 1.000 84.21000  ? 162 ARG A HA   1 
ATOM   2281 H HB2  . ARG A 1 162 ? -12.73900 -0.96900  -24.87100 1.000 98.45000  ? 162 ARG A HB2  1 
ATOM   2282 H HB3  . ARG A 1 162 ? -13.60900 -0.52800  -23.61900 1.000 98.45000  ? 162 ARG A HB3  1 
ATOM   2283 H HG2  . ARG A 1 162 ? -11.63400 -0.74700  -22.29200 1.000 142.97000 ? 162 ARG A HG2  1 
ATOM   2284 H HG3  . ARG A 1 162 ? -10.82300 -0.91600  -23.65200 1.000 142.97000 ? 162 ARG A HG3  1 
ATOM   2285 H HD2  . ARG A 1 162 ? -12.30900 1.38500   -22.97600 1.000 151.98000 ? 162 ARG A HD2  1 
ATOM   2286 H HD3  . ARG A 1 162 ? -10.72500 1.30300   -22.90800 1.000 151.98000 ? 162 ARG A HD3  1 
ATOM   2287 H HE   . ARG A 1 162 ? -12.18500 1.60100   -25.16300 1.000 148.65000 ? 162 ARG A HE   1 
ATOM   2288 H HH11 . ARG A 1 162 ? -9.09400  0.98600   -24.09800 1.000 172.08000 ? 162 ARG A HH11 1 
ATOM   2289 H HH12 . ARG A 1 162 ? -8.42800  1.34600   -25.37900 1.000 172.08000 ? 162 ARG A HH12 1 
ATOM   2290 H HH21 . ARG A 1 162 ? -11.13300 2.14500   -27.07100 1.000 138.22000 ? 162 ARG A HH21 1 
ATOM   2291 H HH22 . ARG A 1 162 ? -9.65000  2.04200   -27.16900 1.000 138.22000 ? 162 ARG A HH22 1 
ATOM   2292 N N    . GLY A 1 163 ? -15.39300 -3.36500  -23.19000 1.000 83.37000  ? 163 GLY A N    1 
ATOM   2293 C CA   . GLY A 1 163 ? -16.78300 -3.62900  -23.47200 1.000 83.80000  ? 163 GLY A CA   1 
ATOM   2294 C C    . GLY A 1 163 ? -17.08100 -5.01100  -24.01900 1.000 83.70000  ? 163 GLY A C    1 
ATOM   2295 O O    . GLY A 1 163 ? -18.19600 -5.51000  -23.83400 1.000 84.07000  ? 163 GLY A O    1 
ATOM   2296 H H    . GLY A 1 163 ? -15.17600 -3.52400  -22.37300 1.000 81.12000  ? 163 GLY A H    1 
ATOM   2297 H HA2  . GLY A 1 163 ? -17.29500 -3.51500  -22.65600 1.000 84.86000  ? 163 GLY A HA2  1 
ATOM   2298 H HA3  . GLY A 1 163 ? -17.10100 -2.97900  -24.11800 1.000 84.86000  ? 163 GLY A HA3  1 
ATOM   2299 N N    . GLY A 1 164 ? -16.11800 -5.64200  -24.67800 1.000 64.58000  ? 164 GLY A N    1 
ATOM   2300 C CA   . GLY A 1 164 ? -16.34700 -6.88700  -25.37900 1.000 64.44000  ? 164 GLY A CA   1 
ATOM   2301 C C    . GLY A 1 164 ? -16.05500 -8.11600  -24.54600 1.000 62.61000  ? 164 GLY A C    1 
ATOM   2302 O O    . GLY A 1 164 ? -15.96600 -8.06900  -23.31600 1.000 61.90000  ? 164 GLY A O    1 
ATOM   2303 H H    . GLY A 1 164 ? -15.30800 -5.36000  -24.73200 1.000 84.39000  ? 164 GLY A H    1 
ATOM   2304 H HA2  . GLY A 1 164 ? -17.27300 -6.92700  -25.66500 1.000 83.26000  ? 164 GLY A HA2  1 
ATOM   2305 H HA3  . GLY A 1 164 ? -15.78400 -6.91600  -26.16900 1.000 83.26000  ? 164 GLY A HA3  1 
ATOM   2306 N N    . ASN A 1 165 ? -15.91200 -9.24300  -25.24400 1.000 63.02000  ? 165 ASN A N    1 
ATOM   2307 C CA   . ASN A 1 165 ? -15.60800 -10.51600 -24.61000 1.000 62.06000  ? 165 ASN A CA   1 
ATOM   2308 C C    . ASN A 1 165 ? -14.12700 -10.85600 -24.63600 1.000 61.11000  ? 165 ASN A C    1 
ATOM   2309 O O    . ASN A 1 165 ? -13.70500 -11.76700 -23.91600 1.000 60.88000  ? 165 ASN A O    1 
ATOM   2310 C CB   . ASN A 1 165 ? -16.37900 -11.65000 -25.29800 1.000 62.47000  ? 165 ASN A CB   1 
ATOM   2311 C CG   . ASN A 1 165 ? -17.87600 -11.41900 -25.30500 1.000 63.43000  ? 165 ASN A CG   1 
ATOM   2312 O OD1  . ASN A 1 165 ? -18.41600 -10.79900 -26.22100 1.000 63.84000  ? 165 ASN A OD1  1 
ATOM   2313 N ND2  . ASN A 1 165 ? -18.55800 -11.92200 -24.28100 1.000 63.15000  ? 165 ASN A ND2  1 
ATOM   2314 H H    . ASN A 1 165 ? -15.98800 -9.29200  -26.09900 1.000 69.37000  ? 165 ASN A H    1 
ATOM   2315 H HA   . ASN A 1 165 ? -15.89100 -10.48300 -23.68300 1.000 66.07000  ? 165 ASN A HA   1 
ATOM   2316 H HB2  . ASN A 1 165 ? -16.08200 -11.72000 -26.21900 1.000 70.94000  ? 165 ASN A HB2  1 
ATOM   2317 H HB3  . ASN A 1 165 ? -16.20600 -12.48100 -24.82900 1.000 70.94000  ? 165 ASN A HB3  1 
ATOM   2318 H HD21 . ASN A 1 165 ? -18.14600 -12.35000 -23.65900 1.000 78.22000  ? 165 ASN A HD21 1 
ATOM   2319 H HD22 . ASN A 1 165 ? -19.41100 -11.81800 -24.24000 1.000 78.22000  ? 165 ASN A HD22 1 
ATOM   2320 N N    . THR A 1 166 ? -13.33600 -10.15400 -25.44200 1.000 37.05000  ? 166 THR A N    1 
ATOM   2321 C CA   . THR A 1 166 ? -11.93200 -10.50500 -25.59300 1.000 36.71000  ? 166 THR A CA   1 
ATOM   2322 C C    . THR A 1 166 ? -11.19100 -10.35900 -24.26900 1.000 35.57000  ? 166 THR A C    1 
ATOM   2323 O O    . THR A 1 166 ? -11.32600 -9.35200  -23.56800 1.000 35.85000  ? 166 THR A O    1 
ATOM   2324 C CB   . THR A 1 166 ? -11.27700 -9.62900  -26.66200 1.000 36.53000  ? 166 THR A CB   1 
ATOM   2325 O OG1  . THR A 1 166 ? -11.80900 -9.96100  -27.95000 1.000 37.63000  ? 166 THR A OG1  1 
ATOM   2326 C CG2  . THR A 1 166 ? -9.76900  -9.83500  -26.67200 1.000 35.66000  ? 166 THR A CG2  1 
ATOM   2327 H H    . THR A 1 166 ? -13.58600 -9.47600  -25.90800 1.000 51.23000  ? 166 THR A H    1 
ATOM   2328 H HA   . THR A 1 166 ? -11.86500 -11.42900 -25.87800 1.000 54.91000  ? 166 THR A HA   1 
ATOM   2329 H HB   . THR A 1 166 ? -11.45800 -8.69700  -26.47000 1.000 47.89000  ? 166 THR A HB   1 
ATOM   2330 H HG1  . THR A 1 166 ? -11.65600 -10.76800 -28.12500 1.000 55.88000  ? 166 THR A HG1  1 
ATOM   2331 H HG21 . THR A 1 166 ? -9.40100  -9.53300  -27.51700 1.000 48.17000  ? 166 THR A HG21 1 
ATOM   2332 H HG22 . THR A 1 166 ? -9.35700  -9.33000  -25.95300 1.000 48.17000  ? 166 THR A HG22 1 
ATOM   2333 H HG23 . THR A 1 166 ? -9.56200  -10.77600 -26.55900 1.000 48.17000  ? 166 THR A HG23 1 
ATOM   2334 N N    . VAL A 1 167 ? -10.40000 -11.37800 -23.93800 1.000 37.31000  ? 167 VAL A N    1 
ATOM   2335 C CA   . VAL A 1 167 ? -9.50200  -11.37200 -22.79400 1.000 36.95000  ? 167 VAL A CA   1 
ATOM   2336 C C    . VAL A 1 167 ? -8.15200  -11.87800 -23.27800 1.000 35.57000  ? 167 VAL A C    1 
ATOM   2337 O O    . VAL A 1 167 ? -8.02700  -12.42400 -24.37500 1.000 35.22000  ? 167 VAL A O    1 
ATOM   2338 C CB   . VAL A 1 167 ? -10.02300 -12.24000 -21.63400 1.000 36.42000  ? 167 VAL A CB   1 
ATOM   2339 C CG1  . VAL A 1 167 ? -11.26400 -11.61000 -21.03600 1.000 37.76000  ? 167 VAL A CG1  1 
ATOM   2340 C CG2  . VAL A 1 167 ? -10.30200 -13.65200 -22.12800 1.000 35.32000  ? 167 VAL A CG2  1 
ATOM   2341 H H    . VAL A 1 167 ? -10.36800 -12.11300 -24.38400 1.000 41.21000  ? 167 VAL A H    1 
ATOM   2342 H HA   . VAL A 1 167 ? -9.39200  -10.46400 -22.47200 1.000 44.44000  ? 167 VAL A HA   1 
ATOM   2343 H HB   . VAL A 1 167 ? -9.34500  -12.28900 -20.94200 1.000 43.67000  ? 167 VAL A HB   1 
ATOM   2344 H HG11 . VAL A 1 167 ? -11.57900 -12.16500 -20.30500 1.000 46.69000  ? 167 VAL A HG11 1 
ATOM   2345 H HG12 . VAL A 1 167 ? -11.04100 -10.72500 -20.70700 1.000 46.69000  ? 167 VAL A HG12 1 
ATOM   2346 H HG13 . VAL A 1 167 ? -11.94700 -11.54700 -21.72200 1.000 46.69000  ? 167 VAL A HG13 1 
ATOM   2347 H HG21 . VAL A 1 167 ? -10.66000 -14.17500 -21.39400 1.000 42.60000  ? 167 VAL A HG21 1 
ATOM   2348 H HG22 . VAL A 1 167 ? -10.94800 -13.61500 -22.85100 1.000 42.60000  ? 167 VAL A HG22 1 
ATOM   2349 H HG23 . VAL A 1 167 ? -9.47500  -14.05000 -22.44200 1.000 42.60000  ? 167 VAL A HG23 1 
ATOM   2350 N N    . ILE A 1 168 ? -7.12800  -11.68400 -22.45300 1.000 40.73000  ? 168 ILE A N    1 
ATOM   2351 C CA   . ILE A 1 168 ? -5.77200  -12.07800 -22.81800 1.000 39.16000  ? 168 ILE A CA   1 
ATOM   2352 C C    . ILE A 1 168 ? -5.06800  -12.63900 -21.59500 1.000 37.52000  ? 168 ILE A C    1 
ATOM   2353 O O    . ILE A 1 168 ? -4.99900  -11.97700 -20.55400 1.000 37.90000  ? 168 ILE A O    1 
ATOM   2354 C CB   . ILE A 1 168 ? -4.96400  -10.90100 -23.39900 1.000 39.87000  ? 168 ILE A CB   1 
ATOM   2355 C CG1  . ILE A 1 168 ? -5.67200  -10.33200 -24.63000 1.000 41.16000  ? 168 ILE A CG1  1 
ATOM   2356 C CG2  . ILE A 1 168 ? -3.54400  -11.35900 -23.72100 1.000 38.25000  ? 168 ILE A CG2  1 
ATOM   2357 C CD1  . ILE A 1 168 ? -5.50700  -8.83200  -24.77900 1.000 43.67000  ? 168 ILE A CD1  1 
ATOM   2358 H H    . ILE A 1 168 ? -7.19200  -11.32500 -21.67400 1.000 46.62000  ? 168 ILE A H    1 
ATOM   2359 H HA   . ILE A 1 168 ? -5.81100  -12.77700 -23.48900 1.000 45.85000  ? 168 ILE A HA   1 
ATOM   2360 H HB   . ILE A 1 168 ? -4.91400  -10.20400 -22.72600 1.000 46.29000  ? 168 ILE A HB   1 
ATOM   2361 H HG12 . ILE A 1 168 ? -5.29500  -10.74700 -25.42100 1.000 46.59000  ? 168 ILE A HG12 1 
ATOM   2362 H HG13 . ILE A 1 168 ? -6.61800  -10.50500 -24.59400 1.000 46.59000  ? 168 ILE A HG13 1 
ATOM   2363 H HG21 . ILE A 1 168 ? -3.13100  -10.70800 -24.31000 1.000 43.77000  ? 168 ILE A HG21 1 
ATOM   2364 H HG22 . ILE A 1 168 ? -3.03600  -11.42700 -22.89700 1.000 43.77000  ? 168 ILE A HG22 1 
ATOM   2365 H HG23 . ILE A 1 168 ? -3.58300  -12.22300 -24.16000 1.000 43.77000  ? 168 ILE A HG23 1 
ATOM   2366 H HD11 . ILE A 1 168 ? -5.75800  -8.58000  -25.68100 1.000 62.36000  ? 168 ILE A HD11 1 
ATOM   2367 H HD12 . ILE A 1 168 ? -6.08000  -8.38500  -24.13600 1.000 62.36000  ? 168 ILE A HD12 1 
ATOM   2368 H HD13 . ILE A 1 168 ? -4.57900  -8.59900  -24.61800 1.000 62.36000  ? 168 ILE A HD13 1 
ATOM   2369 N N    . CYS A 1 169 ? -4.52000  -13.84500 -21.72900 1.000 41.02000  ? 169 CYS A N    1 
ATOM   2370 C CA   . CYS A 1 169 ? -3.69400  -14.45300 -20.69600 1.000 39.10000  ? 169 CYS A CA   1 
ATOM   2371 C C    . CYS A 1 169 ? -2.23500  -14.38200 -21.13200 1.000 38.69000  ? 169 CYS A C    1 
ATOM   2372 O O    . CYS A 1 169 ? -1.89200  -14.81000 -22.24000 1.000 38.92000  ? 169 CYS A O    1 
ATOM   2373 C CB   . CYS A 1 169 ? -4.11500  -15.89900 -20.43400 1.000 37.31000  ? 169 CYS A CB   1 
ATOM   2374 S SG   . CYS A 1 169 ? -3.27000  -17.15100 -21.40400 1.000 38.03000  ? 169 CYS A SG   1 
ATOM   2375 H H    . CYS A 1 169 ? -4.61600  -14.33900 -22.42600 1.000 41.96000  ? 169 CYS A H    1 
ATOM   2376 H HA   . CYS A 1 169 ? -3.79000  -13.95500 -19.87000 1.000 38.67000  ? 169 CYS A HA   1 
ATOM   2377 H HB2  . CYS A 1 169 ? -3.93200  -16.09800 -19.50400 1.000 32.00000  ? 169 CYS A HB2  1 
ATOM   2378 H HB3  . CYS A 1 169 ? -5.06400  -15.98400 -20.61100 1.000 32.00000  ? 169 CYS A HB3  1 
ATOM   2379 H HG   . CYS A 1 169 ? -3.46800  -16.90200 -22.55900 1.000 47.84000  ? 169 CYS A HG   1 
ATOM   2380 N N    . ALA A 1 170 ? -1.38800  -13.82000 -20.27400 1.000 30.40000  ? 170 ALA A N    1 
ATOM   2381 C CA   . ALA A 1 170 ? 0.04600   -13.80900 -20.52100 1.000 29.47000  ? 170 ALA A CA   1 
ATOM   2382 C C    . ALA A 1 170 ? 0.62200   -15.18300 -20.21600 1.000 28.27000  ? 170 ALA A C    1 
ATOM   2383 O O    . ALA A 1 170 ? 0.24300   -15.82500 -19.23300 1.000 27.82000  ? 170 ALA A O    1 
ATOM   2384 C CB   . ALA A 1 170 ? 0.73100   -12.74600 -19.66400 1.000 30.96000  ? 170 ALA A CB   1 
ATOM   2385 H H    . ALA A 1 170 ? -1.62100  -13.43800 -19.54000 1.000 40.66000  ? 170 ALA A H    1 
ATOM   2386 H HA   . ALA A 1 170 ? 0.21200   -13.60600 -21.45500 1.000 33.19000  ? 170 ALA A HA   1 
ATOM   2387 H HB1  . ALA A 1 170 ? 0.41800   -12.82600 -18.74900 1.000 40.47000  ? 170 ALA A HB1  1 
ATOM   2388 H HB2  . ALA A 1 170 ? 1.69100   -12.87900 -19.70100 1.000 40.47000  ? 170 ALA A HB2  1 
ATOM   2389 H HB3  . ALA A 1 170 ? 0.50200   -11.87500 -20.01900 1.000 40.47000  ? 170 ALA A HB3  1 
ATOM   2390 N N    . THR A 1 171 ? 1.53500   -15.63900 -21.06900 1.000 38.57000  ? 171 THR A N    1 
ATOM   2391 C CA   . THR A 1 171 ? 2.10000   -16.97400 -20.96000 1.000 37.82000  ? 171 THR A CA   1 
ATOM   2392 C C    . THR A 1 171 ? 3.59600   -16.89000 -20.68500 1.000 38.35000  ? 171 THR A C    1 
ATOM   2393 O O    . THR A 1 171 ? 4.23300   -15.85400 -20.89700 1.000 39.66000  ? 171 THR A O    1 
ATOM   2394 C CB   . THR A 1 171 ? 1.86000   -17.79100 -22.23700 1.000 38.51000  ? 171 THR A CB   1 
ATOM   2395 O OG1  . THR A 1 171 ? 2.69800   -17.29500 -23.28700 1.000 40.09000  ? 171 THR A OG1  1 
ATOM   2396 C CG2  . THR A 1 171 ? 0.40200   -17.70000 -22.66900 1.000 38.81000  ? 171 THR A CG2  1 
ATOM   2397 H H    . THR A 1 171 ? 1.84600   -15.18400 -21.72900 1.000 41.84000  ? 171 THR A H    1 
ATOM   2398 H HA   . THR A 1 171 ? 1.68300   -17.44200 -20.22000 1.000 40.53000  ? 171 THR A HA   1 
ATOM   2399 H HB   . THR A 1 171 ? 2.07200   -18.72200 -22.06800 1.000 43.52000  ? 171 THR A HB   1 
ATOM   2400 H HG1  . THR A 1 171 ? 2.94600   -17.92800 -23.77900 1.000 52.14000  ? 171 THR A HG1  1 
ATOM   2401 H HG21 . THR A 1 171 ? 0.23600   -18.31200 -23.40300 1.000 43.82000  ? 171 THR A HG21 1 
ATOM   2402 H HG22 . THR A 1 171 ? -0.17800  -17.93300 -21.92700 1.000 43.82000  ? 171 THR A HG22 1 
ATOM   2403 H HG23 . THR A 1 171 ? 0.19600   -16.79700 -22.95800 1.000 43.82000  ? 171 THR A HG23 1 
ATOM   2404 N N    . GLN A 1 172 ? 4.15300   -18.00100 -20.21300 1.000 50.87000  ? 172 GLN A N    1 
ATOM   2405 C CA   . GLN A 1 172 ? 5.57300   -18.06000 -19.88300 1.000 51.68000  ? 172 GLN A CA   1 
ATOM   2406 C C    . GLN A 1 172 ? 6.41700   -18.01600 -21.15200 1.000 52.20000  ? 172 GLN A C    1 
ATOM   2407 O O    . GLN A 1 172 ? 7.57100   -17.59100 -21.12700 1.000 53.93000  ? 172 GLN A O    1 
ATOM   2408 C CB   . GLN A 1 172 ? 5.92100   -19.29700 -19.05100 1.000 51.62000  ? 172 GLN A CB   1 
ATOM   2409 C CG   . GLN A 1 172 ? 5.95800   -20.59800 -19.83800 1.000 52.79000  ? 172 GLN A CG   1 
ATOM   2410 C CD   . GLN A 1 172 ? 6.17800   -21.81200 -18.95000 1.000 53.32000  ? 172 GLN A CD   1 
ATOM   2411 O OE1  . GLN A 1 172 ? 6.85800   -21.73000 -17.92600 1.000 53.67000  ? 172 GLN A OE1  1 
ATOM   2412 N NE2  . GLN A 1 172 ? 5.60800   -22.94800 -19.34100 1.000 53.53000  ? 172 GLN A NE2  1 
ATOM   2413 H H    . GLN A 1 172 ? 3.72900   -18.73600 -20.07400 1.000 47.06000  ? 172 GLN A H    1 
ATOM   2414 H HA   . GLN A 1 172 ? 5.79900   -17.27900 -19.35400 1.000 50.23000  ? 172 GLN A HA   1 
ATOM   2415 H HB2  . GLN A 1 172 ? 6.79700   -19.16800 -18.65500 1.000 51.26000  ? 172 GLN A HB2  1 
ATOM   2416 H HB3  . GLN A 1 172 ? 5.25800   -19.39600 -18.35000 1.000 51.26000  ? 172 GLN A HB3  1 
ATOM   2417 H HG2  . GLN A 1 172 ? 5.11300   -20.71300 -20.30100 1.000 60.70000  ? 172 GLN A HG2  1 
ATOM   2418 H HG3  . GLN A 1 172 ? 6.68600   -20.56500 -20.47700 1.000 60.70000  ? 172 GLN A HG3  1 
ATOM   2419 H HE21 . GLN A 1 172 ? 5.14100   -22.96800 -20.06300 1.000 60.15000  ? 172 GLN A HE21 1 
ATOM   2420 H HE22 . GLN A 1 172 ? 5.70500   -23.66200 -18.87100 1.000 60.15000  ? 172 GLN A HE22 1 
HETATM 2421 C C01  . AG7 B 2 .   ? -5.85000  -3.30800  -20.87700 1.000 54.95000  ? 201 AG7 A C01  1 
HETATM 2422 C C02  . AG7 B 2 .   ? -4.43100  -2.98800  -20.48600 1.000 55.31000  ? 201 AG7 A C02  1 
HETATM 2423 O O03  . AG7 B 2 .   ? -6.40500  -4.25700  -20.37200 1.000 54.70000  ? 201 AG7 A O03  1 
HETATM 2424 C C04  . AG7 B 2 .   ? -3.97800  -3.69700  -19.21700 1.000 54.18000  ? 201 AG7 A C04  1 
HETATM 2425 C C05  . AG7 B 2 .   ? -2.58400  -3.12900  -18.84700 1.000 53.56000  ? 201 AG7 A C05  1 
HETATM 2426 C C06  . AG7 B 2 .   ? -1.90000  -3.67900  -17.61700 1.000 53.54000  ? 201 AG7 A C06  1 
HETATM 2427 C C07  . AG7 B 2 .   ? -1.59900  -5.03500  -17.56900 1.000 53.28000  ? 201 AG7 A C07  1 
HETATM 2428 C C08  . AG7 B 2 .   ? -0.97000  -5.60900  -16.47700 1.000 51.75000  ? 201 AG7 A C08  1 
HETATM 2429 C C09  . AG7 B 2 .   ? -0.62900  -4.80400  -15.40800 1.000 52.50000  ? 201 AG7 A C09  1 
HETATM 2430 C C10  . AG7 B 2 .   ? -0.89800  -3.44800  -15.40300 1.000 52.94000  ? 201 AG7 A C10  1 
HETATM 2431 C C11  . AG7 B 2 .   ? -1.53100  -2.89300  -16.51700 1.000 53.92000  ? 201 AG7 A C11  1 
HETATM 2432 N N12  . AG7 B 2 .   ? -5.34200  -4.66300  -17.52900 1.000 53.68000  ? 201 AG7 A N12  1 
HETATM 2433 C C13  . AG7 B 2 .   ? -6.17800  -4.76700  -16.36100 1.000 53.53000  ? 201 AG7 A C13  1 
HETATM 2434 C C14  . AG7 B 2 .   ? -7.40300  -5.62800  -16.61200 1.000 53.52000  ? 201 AG7 A C14  1 
HETATM 2435 C C15  . AG7 B 2 .   ? -8.37400  -5.13900  -17.69700 1.000 53.84000  ? 201 AG7 A C15  1 
HETATM 2436 C C16  . AG7 B 2 .   ? -9.71200  -5.86700  -17.61800 1.000 54.06000  ? 201 AG7 A C16  1 
HETATM 2437 N N17  . AG7 B 2 .   ? -10.69300 -4.95800  -17.65900 1.000 54.74000  ? 201 AG7 A N17  1 
HETATM 2438 O O18  . AG7 B 2 .   ? -9.88200  -7.07200  -17.53800 1.000 53.83000  ? 201 AG7 A O18  1 
HETATM 2439 C C19  . AG7 B 2 .   ? -5.38700  -5.40600  -15.20700 1.000 52.76000  ? 201 AG7 A C19  1 
HETATM 2440 C C20  . AG7 B 2 .   ? -4.12200  -4.68500  -14.76000 1.000 52.56000  ? 201 AG7 A C20  1 
HETATM 2441 C C21  . AG7 B 2 .   ? -4.33900  -3.68100  -13.66700 1.000 52.80000  ? 201 AG7 A C21  1 
HETATM 2442 O O22  . AG7 B 2 .   ? -5.26100  -2.79100  -14.00800 1.000 53.34000  ? 201 AG7 A O22  1 
HETATM 2443 O O23  . AG7 B 2 .   ? -3.74800  -3.67400  -12.61300 1.000 53.37000  ? 201 AG7 A O23  1 
HETATM 2444 C C47  . AG7 B 2 .   ? -4.87500  -3.50700  -18.01300 1.000 54.05000  ? 201 AG7 A C47  1 
HETATM 2445 O O48  . AG7 B 2 .   ? -5.10000  -2.40800  -17.52800 1.000 54.51000  ? 201 AG7 A O48  1 
HETATM 2446 C C50  . AG7 B 2 .   ? -4.97100  -1.38500  -13.89600 1.000 53.86000  ? 201 AG7 A C50  1 
HETATM 2447 C C53  . AG7 B 2 .   ? -3.63400  -1.01200  -14.51500 1.000 54.27000  ? 201 AG7 A C53  1 
HETATM 2448 C C57  . AG7 B 2 .   ? -6.58800  -2.43100  -21.91800 1.000 56.50000  ? 201 AG7 A C57  1 
HETATM 2449 N N58  . AG7 B 2 .   ? -6.99200  -3.44000  -22.89300 1.000 56.29000  ? 201 AG7 A N58  1 
HETATM 2450 C C59  . AG7 B 2 .   ? -6.16900  -3.86500  -23.88600 1.000 56.85000  ? 201 AG7 A C59  1 
HETATM 2451 O O60  . AG7 B 2 .   ? -5.03600  -3.44500  -24.05800 1.000 56.92000  ? 201 AG7 A O60  1 
HETATM 2452 C C78  . AG7 B 2 .   ? -7.65900  -1.54100  -21.27200 1.000 57.82000  ? 201 AG7 A C78  1 
HETATM 2453 C C81  . AG7 B 2 .   ? -8.93400  -2.34200  -21.06700 1.000 58.36000  ? 201 AG7 A C81  1 
HETATM 2454 F F1   . AG7 B 2 .   ? -0.01900  -5.37100  -14.35000 1.000 52.13000  ? 201 AG7 A F1   1 
HETATM 2455 C C82  . AG7 B 2 .   ? -7.15800  -0.94700  -19.94200 1.000 57.24000  ? 201 AG7 A C82  1 
HETATM 2456 C C83  . AG7 B 2 .   ? -10.26300 -3.58300  -17.74500 1.000 55.18000  ? 201 AG7 A C83  1 
HETATM 2457 C C84  . AG7 B 2 .   ? -8.74400  -3.65600  -17.54600 1.000 54.27000  ? 201 AG7 A C84  1 
HETATM 2458 C C1   . AG7 B 2 .   ? -6.68500  -4.92200  -24.81300 1.000 56.75000  ? 201 AG7 A C1   1 
HETATM 2459 C C2   . AG7 B 2 .   ? -6.19300  -5.25200  -26.10100 1.000 56.19000  ? 201 AG7 A C2   1 
HETATM 2460 C C3   . AG7 B 2 .   ? -6.98400  -6.27900  -26.51000 1.000 56.17000  ? 201 AG7 A C3   1 
HETATM 2461 O O4   . AG7 B 2 .   ? -7.86500  -6.54200  -25.52800 1.000 57.11000  ? 201 AG7 A O4   1 
HETATM 2462 N N5   . AG7 B 2 .   ? -7.67000  -5.70600  -24.48300 1.000 57.20000  ? 201 AG7 A N5   1 
HETATM 2463 C C4   . AG7 B 2 .   ? -7.02900  -7.09300  -27.75400 1.000 56.48000  ? 201 AG7 A C4   1 
HETATM 2464 H H2   . AG7 B 2 .   ? -3.82600  -3.17000  -21.22200 1.000 56.83000  ? 201 AG7 A H2   1 
HETATM 2465 H H3   . AG7 B 2 .   ? -4.40700  -2.02600  -20.36800 1.000 56.83000  ? 201 AG7 A H3   1 
HETATM 2466 H H27  . AG7 B 2 .   ? -3.88600  -4.64200  -19.41300 1.000 53.46000  ? 201 AG7 A H27  1 
HETATM 2467 H H28  . AG7 B 2 .   ? -2.00000  -3.25800  -19.61000 1.000 50.33000  ? 201 AG7 A H28  1 
HETATM 2468 H H29  . AG7 B 2 .   ? -2.66800  -2.16800  -18.74300 1.000 50.33000  ? 201 AG7 A H29  1 
HETATM 2469 H H30  . AG7 B 2 .   ? -1.82700  -5.58600  -18.28300 1.000 65.86000  ? 201 AG7 A H30  1 
HETATM 2470 H H31  . AG7 B 2 .   ? -0.78100  -6.51900  -16.46000 1.000 55.40000  ? 201 AG7 A H31  1 
HETATM 2471 H H33  . AG7 B 2 .   ? -0.66200  -2.91900  -14.67600 1.000 60.48000  ? 201 AG7 A H33  1 
HETATM 2472 H H34  . AG7 B 2 .   ? -1.71800  -1.98200  -16.52100 1.000 64.48000  ? 201 AG7 A H34  1 
HETATM 2473 H H49  . AG7 B 2 .   ? -5.11100  -5.39100  -17.92800 1.000 51.75000  ? 201 AG7 A H49  1 
HETATM 2474 H H91  . AG7 B 2 .   ? -6.44400  -3.87000  -16.10800 1.000 53.78000  ? 201 AG7 A H91  1 
HETATM 2475 H H35  . AG7 B 2 .   ? -7.88100  -5.74900  -15.77700 1.000 50.13000  ? 201 AG7 A H35  1 
HETATM 2476 H H36  . AG7 B 2 .   ? -7.14200  -6.52200  -16.88900 1.000 50.13000  ? 201 AG7 A H36  1 
HETATM 2477 H H94  . AG7 B 2 .   ? -7.97500  -5.32300  -18.56200 1.000 43.84000  ? 201 AG7 A H94  1 
HETATM 2478 H H39  . AG7 B 2 .   ? -11.52300 -5.18100  -17.62100 1.000 53.77000  ? 201 AG7 A H39  1 
HETATM 2479 H H191 . AG7 B 2 .   ? -6.13600  -5.42800  -14.55700 1.000 56.77000  ? 201 AG7 A H191 1 
HETATM 2480 H H192 . AG7 B 2 .   ? -5.46600  -5.79900  -16.12700 1.000 56.77000  ? 201 AG7 A H192 1 
HETATM 2481 H H41  . AG7 B 2 .   ? -3.79600  -4.16400  -15.51000 1.000 58.02000  ? 201 AG7 A H41  1 
HETATM 2482 H H42  . AG7 B 2 .   ? -3.33100  -5.18100  -14.48100 1.000 58.02000  ? 201 AG7 A H42  1 
HETATM 2483 H H51  . AG7 B 2 .   ? -4.98000  -1.14100  -12.95700 1.000 64.14000  ? 201 AG7 A H51  1 
HETATM 2484 H H52  . AG7 B 2 .   ? -5.68200  -0.88300  -14.32400 1.000 64.14000  ? 201 AG7 A H52  1 
HETATM 2485 H H53  . AG7 B 2 .   ? -2.89200  -1.40900  -14.03300 1.000 64.56000  ? 201 AG7 A H53  1 
HETATM 2486 H H54  . AG7 B 2 .   ? -3.50500  -0.05200  -14.54000 1.000 64.56000  ? 201 AG7 A H54  1 
HETATM 2487 H H56  . AG7 B 2 .   ? -3.60300  -1.34300  -15.42600 1.000 64.56000  ? 201 AG7 A H56  1 
HETATM 2488 H H77  . AG7 B 2 .   ? -5.93800  -1.86100  -22.35800 1.000 53.72000  ? 201 AG7 A H77  1 
HETATM 2489 H H61  . AG7 B 2 .   ? -7.77600  -3.78700  -22.82400 1.000 51.24000  ? 201 AG7 A H61  1 
HETATM 2490 H H79  . AG7 B 2 .   ? -7.85100  -0.80900  -21.87800 1.000 64.82000  ? 201 AG7 A H79  1 
HETATM 2491 H H82  . AG7 B 2 .   ? -9.31200  -2.60900  -21.91900 1.000 72.28000  ? 201 AG7 A H82  1 
HETATM 2492 H H84  . AG7 B 2 .   ? -8.75100  -3.14900  -20.56100 1.000 72.28000  ? 201 AG7 A H84  1 
HETATM 2493 H H85  . AG7 B 2 .   ? -9.61400  -1.84700  -20.58300 1.000 72.28000  ? 201 AG7 A H85  1 
HETATM 2494 H H86  . AG7 B 2 .   ? -7.05900  -1.61300  -19.24600 1.000 63.19000  ? 201 AG7 A H86  1 
HETATM 2495 H H87  . AG7 B 2 .   ? -7.78300  -0.28000  -19.61700 1.000 63.19000  ? 201 AG7 A H87  1 
HETATM 2496 H H88  . AG7 B 2 .   ? -6.30000  -0.51100  -20.06000 1.000 63.19000  ? 201 AG7 A H88  1 
HETATM 2497 H H89  . AG7 B 2 .   ? -10.50100 -3.20400  -18.60500 1.000 55.37000  ? 201 AG7 A H89  1 
HETATM 2498 H H90  . AG7 B 2 .   ? -10.68800 -3.04100  -17.06200 1.000 55.37000  ? 201 AG7 A H90  1 
HETATM 2499 H H92  . AG7 B 2 .   ? -8.26800  -3.08700  -18.16900 1.000 46.79000  ? 201 AG7 A H92  1 
HETATM 2500 H H93  . AG7 B 2 .   ? -8.53000  -3.35100  -16.65100 1.000 46.79000  ? 201 AG7 A H93  1 
HETATM 2501 H H8   . AG7 B 2 .   ? -5.49600  -4.85200  -26.56900 1.000 56.39000  ? 201 AG7 A H8   1 
HETATM 2502 H H5   . AG7 B 2 .   ? -7.24500  -6.54400  -28.52400 1.000 64.49000  ? 201 AG7 A H5   1 
HETATM 2503 H H6   . AG7 B 2 .   ? -6.17600  -7.52200  -27.92400 1.000 64.49000  ? 201 AG7 A H6   1 
HETATM 2504 H H7   . AG7 B 2 .   ? -7.70800  -7.78100  -27.67000 1.000 64.49000  ? 201 AG7 A H7   1 
HETATM 2505 O O    . HOH C 3 .   ? 5.40000   -13.54700 -21.42200 1.000 30.81000  ? 301 HOH A O    1 
HETATM 2506 O O    . HOH C 3 .   ? 12.38600  -3.95000  -3.50600  1.000 52.14000  ? 302 HOH A O    1 
HETATM 2507 O O    . HOH C 3 .   ? -13.94600 -8.60200  -19.60100 1.000 54.14000  ? 303 HOH A O    1 
HETATM 2508 O O    . HOH C 3 .   ? -5.05300  -5.48500  -11.05800 1.000 49.58000  ? 304 HOH A O    1 
HETATM 2509 O O    . HOH C 3 .   ? 7.73800   -27.67200 -4.44100  1.000 41.75000  ? 305 HOH A O    1 
HETATM 2510 O O    . HOH C 3 .   ? 6.11900   -7.80200  0.09500   1.000 45.80000  ? 306 HOH A O    1 
HETATM 2511 O O    . HOH C 3 .   ? -10.14500 -8.83200  -8.50000  1.000 30.64000  ? 307 HOH A O    1 
HETATM 2512 O O    . HOH C 3 .   ? -23.26000 -16.65700 -21.94000 1.000 53.85000  ? 308 HOH A O    1 
HETATM 2513 O O    . HOH C 3 .   ? -2.09000  -26.62700 -22.48900 1.000 38.28000  ? 309 HOH A O    1 
HETATM 2514 O O    . HOH C 3 .   ? 11.37500  -24.68200 -12.19500 1.000 44.98000  ? 310 HOH A O    1 
HETATM 2515 O O    . HOH C 3 .   ? 2.25600   -20.08900 -19.21500 1.000 49.98000  ? 311 HOH A O    1 
HETATM 2516 O O    . HOH C 3 .   ? 6.94100   -27.40700 -9.12400  1.000 25.41000  ? 312 HOH A O    1 
HETATM 2517 O O    . HOH C 3 .   ? -10.75783 -18.63310 0.00000   0.50  35.02000  ? 313 HOH A O    1 
HETATM 2518 O O    . HOH C 3 .   ? -3.16200  -24.98300 -31.41500 1.000 40.43000  ? 314 HOH A O    1 
HETATM 2519 O O    . HOH C 3 .   ? -18.89200 -20.78600 -28.82800 1.000 32.76000  ? 315 HOH A O    1 
HETATM 2520 O O    . HOH C 3 .   ? -13.30800 -25.97900 -18.17800 1.000 42.47000  ? 316 HOH A O    1 
HETATM 2521 O O    . HOH C 3 .   ? -14.01400 -26.73200 -16.14400 1.000 35.97000  ? 317 HOH A O    1 
# 
