data_9D8P
# 
_entry.id   9D8P 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.401 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9D8P         pdb_00009d8p 10.2210/pdb9d8p/pdb 
WWPDB D_1000287506 ?            ?                   
EMDB  EMD-46645    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-20 
2 'Structure model' 1 1 2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 2 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.journal_volume'          
6  2 'Structure model' '_citation.page_first'              
7  2 'Structure model' '_citation.page_last'               
8  2 'Structure model' '_citation.pdbx_database_id_DOI'    
9  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
10 2 'Structure model' '_citation.title'                   
11 2 'Structure model' '_citation.year'                    
12 2 'Structure model' '_citation_author.identifier_ORCID' 
13 2 'Structure model' '_citation_author.name'             
14 2 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9D8P 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-19 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
EMDB 'Focused map of Cryo-EM structure of Ubiquitin C-degron bound to KLHDC10-EloB/C' EMD-46645 'associated EM volume' 
EMDB 'ARIH1-diUB-CRL2-KLHDC10 complex'                                                EMD-46644 'consensus EM volume'  
# 
_pdbx_contact_author.id                 4 
_pdbx_contact_author.email              schulman@biochem.mpg.de 
_pdbx_contact_author.name_first         Brenda 
_pdbx_contact_author.name_last          Schulman 
_pdbx_contact_author.name_mi            A 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-3083-1126 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Chittori, S.'   1 0000-0003-1417-6552 
'Scott, D.C.'    2 0000-0002-7688-5568 
'Schulman, B.A.' 3 0000-0002-3083-1126 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   UK 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Nat Commun' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2041-1723 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                9899 
_citation.page_last                 9899 
_citation.title                     'Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41467-024-54126-z 
_citation.pdbx_database_id_PubMed   39548056 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Scott, D.C.'    1  ?                   
primary 'Chittori, S.'   2  0000-0003-1417-6552 
primary 'Purser, N.'     3  0000-0003-2686-2277 
primary 'King, M.T.'     4  0000-0002-4192-8337 
primary 'Maiwald, S.A.'  5  0000-0002-7235-2748 
primary 'Churion, K.'    6  ?                   
primary 'Nourse, A.'     7  0000-0003-4595-5321 
primary 'Lee, C.'        8  0000-0002-5512-8146 
primary 'Paulo, J.A.'    9  0000-0002-4291-413X 
primary 'Miller, D.J.'   10 ?                   
primary 'Elledge, S.J.'  11 0000-0001-7923-6283 
primary 'Harper, J.W.'   12 0000-0002-6944-7236 
primary 'Kleiger, G.'    13 0000-0003-3924-1680 
primary 'Schulman, B.A.' 14 0000-0002-3083-1126 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Kelch domain-containing protein 10' 45745.375 1 ? ?    'residues 41-442' ? 
2 polymer man Elongin-B                            13147.781 1 ? ?    ?                 ? 
3 polymer man Elongin-C                            12485.135 1 ? ?    ?                 ? 
4 polymer man Ubiquitin-C                          8550.794  1 ? K48C ?                 ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
2 
;EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
;
3 
;EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;QLNRFVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGP
DNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR
GKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTS
WTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATM
PEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQGLIER
LK
;
;QLNRFVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGP
DNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR
GKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTS
WTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATM
PEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQGLIER
LK
;
A ? 
2 'polypeptide(L)' no no 
;MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR
ADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
;
;MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR
ADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
;
B ? 
3 'polypeptide(L)' no no 
;MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYK
VRYTNSSTEIPEFPIAPEIALELLMAANFLDC
;
;MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYK
VRYTNSSTEIPEFPIAPEIALELLMAANFLDC
;
C ? 
4 'polypeptide(L)' no no MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGCQLEDGRTLSDYNIQKESTLHLVLRLRGG 
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGCQLEDGRTLSDYNIQKESTLHLVLRLRGG D ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLN n 
1 2   LEU n 
1 3   ASN n 
1 4   ARG n 
1 5   PHE n 
1 6   VAL n 
1 7   GLN n 
1 8   LEU n 
1 9   SER n 
1 10  GLY n 
1 11  ARG n 
1 12  PRO n 
1 13  HIS n 
1 14  LEU n 
1 15  PRO n 
1 16  GLY n 
1 17  LYS n 
1 18  LYS n 
1 19  LYS n 
1 20  ILE n 
1 21  ARG n 
1 22  TRP n 
1 23  ASP n 
1 24  PRO n 
1 25  VAL n 
1 26  ARG n 
1 27  ARG n 
1 28  ARG n 
1 29  PHE n 
1 30  ILE n 
1 31  GLN n 
1 32  SER n 
1 33  CYS n 
1 34  PRO n 
1 35  ILE n 
1 36  ILE n 
1 37  ARG n 
1 38  ILE n 
1 39  PRO n 
1 40  ASN n 
1 41  ARG n 
1 42  PHE n 
1 43  LEU n 
1 44  ARG n 
1 45  GLY n 
1 46  HIS n 
1 47  ARG n 
1 48  PRO n 
1 49  PRO n 
1 50  PRO n 
1 51  ALA n 
1 52  ARG n 
1 53  SER n 
1 54  GLY n 
1 55  HIS n 
1 56  ARG n 
1 57  CYS n 
1 58  VAL n 
1 59  ALA n 
1 60  ASP n 
1 61  ASN n 
1 62  THR n 
1 63  ASN n 
1 64  LEU n 
1 65  TYR n 
1 66  VAL n 
1 67  PHE n 
1 68  GLY n 
1 69  GLY n 
1 70  TYR n 
1 71  ASN n 
1 72  PRO n 
1 73  ASP n 
1 74  TYR n 
1 75  ASP n 
1 76  GLU n 
1 77  SER n 
1 78  GLY n 
1 79  GLY n 
1 80  PRO n 
1 81  ASP n 
1 82  ASN n 
1 83  GLU n 
1 84  ASP n 
1 85  TYR n 
1 86  PRO n 
1 87  LEU n 
1 88  PHE n 
1 89  ARG n 
1 90  GLU n 
1 91  LEU n 
1 92  TRP n 
1 93  ARG n 
1 94  TYR n 
1 95  HIS n 
1 96  PHE n 
1 97  ALA n 
1 98  THR n 
1 99  GLY n 
1 100 VAL n 
1 101 TRP n 
1 102 HIS n 
1 103 GLN n 
1 104 MET n 
1 105 GLY n 
1 106 THR n 
1 107 ASP n 
1 108 GLY n 
1 109 TYR n 
1 110 MET n 
1 111 PRO n 
1 112 ARG n 
1 113 GLU n 
1 114 LEU n 
1 115 ALA n 
1 116 SER n 
1 117 MET n 
1 118 SER n 
1 119 LEU n 
1 120 VAL n 
1 121 LEU n 
1 122 HIS n 
1 123 GLY n 
1 124 ASN n 
1 125 ASN n 
1 126 LEU n 
1 127 LEU n 
1 128 VAL n 
1 129 PHE n 
1 130 GLY n 
1 131 GLY n 
1 132 THR n 
1 133 GLY n 
1 134 ILE n 
1 135 PRO n 
1 136 PHE n 
1 137 GLY n 
1 138 GLU n 
1 139 SER n 
1 140 ASN n 
1 141 GLY n 
1 142 ASN n 
1 143 ASP n 
1 144 VAL n 
1 145 HIS n 
1 146 VAL n 
1 147 CYS n 
1 148 ASN n 
1 149 VAL n 
1 150 LYS n 
1 151 TYR n 
1 152 LYS n 
1 153 ARG n 
1 154 TRP n 
1 155 ALA n 
1 156 LEU n 
1 157 LEU n 
1 158 SER n 
1 159 CYS n 
1 160 ARG n 
1 161 GLY n 
1 162 LYS n 
1 163 LYS n 
1 164 PRO n 
1 165 SER n 
1 166 ARG n 
1 167 ILE n 
1 168 TYR n 
1 169 GLY n 
1 170 GLN n 
1 171 ALA n 
1 172 MET n 
1 173 ALA n 
1 174 ILE n 
1 175 ILE n 
1 176 ASN n 
1 177 GLY n 
1 178 SER n 
1 179 LEU n 
1 180 TYR n 
1 181 VAL n 
1 182 PHE n 
1 183 GLY n 
1 184 GLY n 
1 185 THR n 
1 186 THR n 
1 187 GLY n 
1 188 TYR n 
1 189 ILE n 
1 190 TYR n 
1 191 SER n 
1 192 THR n 
1 193 ASP n 
1 194 LEU n 
1 195 HIS n 
1 196 LYS n 
1 197 LEU n 
1 198 ASP n 
1 199 LEU n 
1 200 ASN n 
1 201 THR n 
1 202 ARG n 
1 203 GLU n 
1 204 TRP n 
1 205 THR n 
1 206 GLN n 
1 207 LEU n 
1 208 LYS n 
1 209 PRO n 
1 210 ASN n 
1 211 ASN n 
1 212 LEU n 
1 213 SER n 
1 214 CYS n 
1 215 ASP n 
1 216 LEU n 
1 217 PRO n 
1 218 GLU n 
1 219 GLU n 
1 220 ARG n 
1 221 TYR n 
1 222 ARG n 
1 223 HIS n 
1 224 GLU n 
1 225 ILE n 
1 226 ALA n 
1 227 HIS n 
1 228 ASP n 
1 229 GLY n 
1 230 GLN n 
1 231 ARG n 
1 232 ILE n 
1 233 TYR n 
1 234 ILE n 
1 235 LEU n 
1 236 GLY n 
1 237 GLY n 
1 238 GLY n 
1 239 THR n 
1 240 SER n 
1 241 TRP n 
1 242 THR n 
1 243 ALA n 
1 244 TYR n 
1 245 SER n 
1 246 LEU n 
1 247 ASN n 
1 248 LYS n 
1 249 ILE n 
1 250 HIS n 
1 251 ALA n 
1 252 TYR n 
1 253 ASN n 
1 254 LEU n 
1 255 GLU n 
1 256 THR n 
1 257 ASN n 
1 258 ALA n 
1 259 TRP n 
1 260 GLU n 
1 261 GLU n 
1 262 ILE n 
1 263 ALA n 
1 264 THR n 
1 265 LYS n 
1 266 PRO n 
1 267 HIS n 
1 268 GLU n 
1 269 LYS n 
1 270 ILE n 
1 271 GLY n 
1 272 PHE n 
1 273 PRO n 
1 274 ALA n 
1 275 ALA n 
1 276 ARG n 
1 277 ARG n 
1 278 CYS n 
1 279 HIS n 
1 280 SER n 
1 281 CYS n 
1 282 VAL n 
1 283 GLN n 
1 284 ILE n 
1 285 LYS n 
1 286 ASN n 
1 287 ASP n 
1 288 VAL n 
1 289 PHE n 
1 290 ILE n 
1 291 CYS n 
1 292 GLY n 
1 293 GLY n 
1 294 TYR n 
1 295 ASN n 
1 296 GLY n 
1 297 GLU n 
1 298 VAL n 
1 299 ILE n 
1 300 LEU n 
1 301 GLY n 
1 302 ASP n 
1 303 ILE n 
1 304 TRP n 
1 305 LYS n 
1 306 LEU n 
1 307 ASN n 
1 308 LEU n 
1 309 GLN n 
1 310 THR n 
1 311 PHE n 
1 312 GLN n 
1 313 TRP n 
1 314 VAL n 
1 315 LYS n 
1 316 LEU n 
1 317 PRO n 
1 318 ALA n 
1 319 THR n 
1 320 MET n 
1 321 PRO n 
1 322 GLU n 
1 323 PRO n 
1 324 VAL n 
1 325 TYR n 
1 326 PHE n 
1 327 HIS n 
1 328 CYS n 
1 329 ALA n 
1 330 ALA n 
1 331 VAL n 
1 332 THR n 
1 333 PRO n 
1 334 ALA n 
1 335 GLY n 
1 336 CYS n 
1 337 MET n 
1 338 TYR n 
1 339 ILE n 
1 340 HIS n 
1 341 GLY n 
1 342 GLY n 
1 343 VAL n 
1 344 VAL n 
1 345 ASN n 
1 346 ILE n 
1 347 HIS n 
1 348 GLU n 
1 349 ASN n 
1 350 LYS n 
1 351 ARG n 
1 352 THR n 
1 353 GLY n 
1 354 SER n 
1 355 LEU n 
1 356 PHE n 
1 357 LYS n 
1 358 ILE n 
1 359 TRP n 
1 360 LEU n 
1 361 VAL n 
1 362 VAL n 
1 363 PRO n 
1 364 SER n 
1 365 LEU n 
1 366 LEU n 
1 367 GLU n 
1 368 LEU n 
1 369 ALA n 
1 370 TRP n 
1 371 GLU n 
1 372 LYS n 
1 373 LEU n 
1 374 LEU n 
1 375 ALA n 
1 376 ALA n 
1 377 PHE n 
1 378 PRO n 
1 379 ASN n 
1 380 LEU n 
1 381 ALA n 
1 382 ASN n 
1 383 LEU n 
1 384 SER n 
1 385 ARG n 
1 386 THR n 
1 387 GLN n 
1 388 LEU n 
1 389 LEU n 
1 390 HIS n 
1 391 LEU n 
1 392 GLY n 
1 393 LEU n 
1 394 THR n 
1 395 GLN n 
1 396 GLY n 
1 397 LEU n 
1 398 ILE n 
1 399 GLU n 
1 400 ARG n 
1 401 LEU n 
1 402 LYS n 
2 1   MET n 
2 2   ASP n 
2 3   VAL n 
2 4   PHE n 
2 5   LEU n 
2 6   MET n 
2 7   ILE n 
2 8   ARG n 
2 9   ARG n 
2 10  HIS n 
2 11  LYS n 
2 12  THR n 
2 13  THR n 
2 14  ILE n 
2 15  PHE n 
2 16  THR n 
2 17  ASP n 
2 18  ALA n 
2 19  LYS n 
2 20  GLU n 
2 21  SER n 
2 22  SER n 
2 23  THR n 
2 24  VAL n 
2 25  PHE n 
2 26  GLU n 
2 27  LEU n 
2 28  LYS n 
2 29  ARG n 
2 30  ILE n 
2 31  VAL n 
2 32  GLU n 
2 33  GLY n 
2 34  ILE n 
2 35  LEU n 
2 36  LYS n 
2 37  ARG n 
2 38  PRO n 
2 39  PRO n 
2 40  ASP n 
2 41  GLU n 
2 42  GLN n 
2 43  ARG n 
2 44  LEU n 
2 45  TYR n 
2 46  LYS n 
2 47  ASP n 
2 48  ASP n 
2 49  GLN n 
2 50  LEU n 
2 51  LEU n 
2 52  ASP n 
2 53  ASP n 
2 54  GLY n 
2 55  LYS n 
2 56  THR n 
2 57  LEU n 
2 58  GLY n 
2 59  GLU n 
2 60  CYS n 
2 61  GLY n 
2 62  PHE n 
2 63  THR n 
2 64  SER n 
2 65  GLN n 
2 66  THR n 
2 67  ALA n 
2 68  ARG n 
2 69  PRO n 
2 70  GLN n 
2 71  ALA n 
2 72  PRO n 
2 73  ALA n 
2 74  THR n 
2 75  VAL n 
2 76  GLY n 
2 77  LEU n 
2 78  ALA n 
2 79  PHE n 
2 80  ARG n 
2 81  ALA n 
2 82  ASP n 
2 83  ASP n 
2 84  THR n 
2 85  PHE n 
2 86  GLU n 
2 87  ALA n 
2 88  LEU n 
2 89  CYS n 
2 90  ILE n 
2 91  GLU n 
2 92  PRO n 
2 93  PHE n 
2 94  SER n 
2 95  SER n 
2 96  PRO n 
2 97  PRO n 
2 98  GLU n 
2 99  LEU n 
2 100 PRO n 
2 101 ASP n 
2 102 VAL n 
2 103 MET n 
2 104 LYS n 
2 105 PRO n 
2 106 GLN n 
2 107 ASP n 
2 108 SER n 
2 109 GLY n 
2 110 SER n 
2 111 SER n 
2 112 ALA n 
2 113 ASN n 
2 114 GLU n 
2 115 GLN n 
2 116 ALA n 
2 117 VAL n 
2 118 GLN n 
3 1   MET n 
3 2   ASP n 
3 3   GLY n 
3 4   GLU n 
3 5   GLU n 
3 6   LYS n 
3 7   THR n 
3 8   TYR n 
3 9   GLY n 
3 10  GLY n 
3 11  CYS n 
3 12  GLU n 
3 13  GLY n 
3 14  PRO n 
3 15  ASP n 
3 16  ALA n 
3 17  MET n 
3 18  TYR n 
3 19  VAL n 
3 20  LYS n 
3 21  LEU n 
3 22  ILE n 
3 23  SER n 
3 24  SER n 
3 25  ASP n 
3 26  GLY n 
3 27  HIS n 
3 28  GLU n 
3 29  PHE n 
3 30  ILE n 
3 31  VAL n 
3 32  LYS n 
3 33  ARG n 
3 34  GLU n 
3 35  HIS n 
3 36  ALA n 
3 37  LEU n 
3 38  THR n 
3 39  SER n 
3 40  GLY n 
3 41  THR n 
3 42  ILE n 
3 43  LYS n 
3 44  ALA n 
3 45  MET n 
3 46  LEU n 
3 47  SER n 
3 48  GLY n 
3 49  PRO n 
3 50  GLY n 
3 51  GLN n 
3 52  PHE n 
3 53  ALA n 
3 54  GLU n 
3 55  ASN n 
3 56  GLU n 
3 57  THR n 
3 58  ASN n 
3 59  GLU n 
3 60  VAL n 
3 61  ASN n 
3 62  PHE n 
3 63  ARG n 
3 64  GLU n 
3 65  ILE n 
3 66  PRO n 
3 67  SER n 
3 68  HIS n 
3 69  VAL n 
3 70  LEU n 
3 71  SER n 
3 72  LYS n 
3 73  VAL n 
3 74  CYS n 
3 75  MET n 
3 76  TYR n 
3 77  PHE n 
3 78  THR n 
3 79  TYR n 
3 80  LYS n 
3 81  VAL n 
3 82  ARG n 
3 83  TYR n 
3 84  THR n 
3 85  ASN n 
3 86  SER n 
3 87  SER n 
3 88  THR n 
3 89  GLU n 
3 90  ILE n 
3 91  PRO n 
3 92  GLU n 
3 93  PHE n 
3 94  PRO n 
3 95  ILE n 
3 96  ALA n 
3 97  PRO n 
3 98  GLU n 
3 99  ILE n 
3 100 ALA n 
3 101 LEU n 
3 102 GLU n 
3 103 LEU n 
3 104 LEU n 
3 105 MET n 
3 106 ALA n 
3 107 ALA n 
3 108 ASN n 
3 109 PHE n 
3 110 LEU n 
3 111 ASP n 
3 112 CYS n 
4 1   MET n 
4 2   GLN n 
4 3   ILE n 
4 4   PHE n 
4 5   VAL n 
4 6   LYS n 
4 7   THR n 
4 8   LEU n 
4 9   THR n 
4 10  GLY n 
4 11  LYS n 
4 12  THR n 
4 13  ILE n 
4 14  THR n 
4 15  LEU n 
4 16  GLU n 
4 17  VAL n 
4 18  GLU n 
4 19  PRO n 
4 20  SER n 
4 21  ASP n 
4 22  THR n 
4 23  ILE n 
4 24  GLU n 
4 25  ASN n 
4 26  VAL n 
4 27  LYS n 
4 28  ALA n 
4 29  LYS n 
4 30  ILE n 
4 31  GLN n 
4 32  ASP n 
4 33  LYS n 
4 34  GLU n 
4 35  GLY n 
4 36  ILE n 
4 37  PRO n 
4 38  PRO n 
4 39  ASP n 
4 40  GLN n 
4 41  GLN n 
4 42  ARG n 
4 43  LEU n 
4 44  ILE n 
4 45  PHE n 
4 46  ALA n 
4 47  GLY n 
4 48  CYS n 
4 49  GLN n 
4 50  LEU n 
4 51  GLU n 
4 52  ASP n 
4 53  GLY n 
4 54  ARG n 
4 55  THR n 
4 56  LEU n 
4 57  SER n 
4 58  ASP n 
4 59  TYR n 
4 60  ASN n 
4 61  ILE n 
4 62  GLN n 
4 63  LYS n 
4 64  GLU n 
4 65  SER n 
4 66  THR n 
4 67  LEU n 
4 68  HIS n 
4 69  LEU n 
4 70  VAL n 
4 71  LEU n 
4 72  ARG n 
4 73  LEU n 
4 74  ARG n 
4 75  GLY n 
4 76  GLY n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 402 human ? 'KLHDC10, KIAA0265' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Trichoplusia ni'  7111 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 118 human ? 'ELOB, TCEB2'       ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Trichoplusia ni'  7111 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 112 human ? 'ELOC, TCEB1'       ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Trichoplusia ni'  7111 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
4 1 sample 'Biological sequence' 1 76  human ? UBC                 ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Escherichia coli' 562  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLN 1   41  41  GLN GLN A . n 
A 1 2   LEU 2   42  42  LEU LEU A . n 
A 1 3   ASN 3   43  43  ASN ASN A . n 
A 1 4   ARG 4   44  44  ARG ARG A . n 
A 1 5   PHE 5   45  45  PHE PHE A . n 
A 1 6   VAL 6   46  46  VAL VAL A . n 
A 1 7   GLN 7   47  47  GLN GLN A . n 
A 1 8   LEU 8   48  48  LEU LEU A . n 
A 1 9   SER 9   49  49  SER SER A . n 
A 1 10  GLY 10  50  50  GLY GLY A . n 
A 1 11  ARG 11  51  ?   ?   ?   A . n 
A 1 12  PRO 12  52  ?   ?   ?   A . n 
A 1 13  HIS 13  53  ?   ?   ?   A . n 
A 1 14  LEU 14  54  ?   ?   ?   A . n 
A 1 15  PRO 15  55  ?   ?   ?   A . n 
A 1 16  GLY 16  56  ?   ?   ?   A . n 
A 1 17  LYS 17  57  ?   ?   ?   A . n 
A 1 18  LYS 18  58  ?   ?   ?   A . n 
A 1 19  LYS 19  59  ?   ?   ?   A . n 
A 1 20  ILE 20  60  ?   ?   ?   A . n 
A 1 21  ARG 21  61  ?   ?   ?   A . n 
A 1 22  TRP 22  62  ?   ?   ?   A . n 
A 1 23  ASP 23  63  ?   ?   ?   A . n 
A 1 24  PRO 24  64  ?   ?   ?   A . n 
A 1 25  VAL 25  65  ?   ?   ?   A . n 
A 1 26  ARG 26  66  ?   ?   ?   A . n 
A 1 27  ARG 27  67  ?   ?   ?   A . n 
A 1 28  ARG 28  68  ?   ?   ?   A . n 
A 1 29  PHE 29  69  ?   ?   ?   A . n 
A 1 30  ILE 30  70  ?   ?   ?   A . n 
A 1 31  GLN 31  71  ?   ?   ?   A . n 
A 1 32  SER 32  72  ?   ?   ?   A . n 
A 1 33  CYS 33  73  ?   ?   ?   A . n 
A 1 34  PRO 34  74  ?   ?   ?   A . n 
A 1 35  ILE 35  75  ?   ?   ?   A . n 
A 1 36  ILE 36  76  ?   ?   ?   A . n 
A 1 37  ARG 37  77  ?   ?   ?   A . n 
A 1 38  ILE 38  78  ?   ?   ?   A . n 
A 1 39  PRO 39  79  ?   ?   ?   A . n 
A 1 40  ASN 40  80  ?   ?   ?   A . n 
A 1 41  ARG 41  81  ?   ?   ?   A . n 
A 1 42  PHE 42  82  ?   ?   ?   A . n 
A 1 43  LEU 43  83  ?   ?   ?   A . n 
A 1 44  ARG 44  84  ?   ?   ?   A . n 
A 1 45  GLY 45  85  ?   ?   ?   A . n 
A 1 46  HIS 46  86  ?   ?   ?   A . n 
A 1 47  ARG 47  87  87  ARG ARG A . n 
A 1 48  PRO 48  88  88  PRO PRO A . n 
A 1 49  PRO 49  89  89  PRO PRO A . n 
A 1 50  PRO 50  90  90  PRO PRO A . n 
A 1 51  ALA 51  91  91  ALA ALA A . n 
A 1 52  ARG 52  92  92  ARG ARG A . n 
A 1 53  SER 53  93  93  SER SER A . n 
A 1 54  GLY 54  94  94  GLY GLY A . n 
A 1 55  HIS 55  95  95  HIS HIS A . n 
A 1 56  ARG 56  96  96  ARG ARG A . n 
A 1 57  CYS 57  97  97  CYS CYS A . n 
A 1 58  VAL 58  98  98  VAL VAL A . n 
A 1 59  ALA 59  99  99  ALA ALA A . n 
A 1 60  ASP 60  100 100 ASP ASP A . n 
A 1 61  ASN 61  101 101 ASN ASN A . n 
A 1 62  THR 62  102 102 THR THR A . n 
A 1 63  ASN 63  103 103 ASN ASN A . n 
A 1 64  LEU 64  104 104 LEU LEU A . n 
A 1 65  TYR 65  105 105 TYR TYR A . n 
A 1 66  VAL 66  106 106 VAL VAL A . n 
A 1 67  PHE 67  107 107 PHE PHE A . n 
A 1 68  GLY 68  108 108 GLY GLY A . n 
A 1 69  GLY 69  109 109 GLY GLY A . n 
A 1 70  TYR 70  110 110 TYR TYR A . n 
A 1 71  ASN 71  111 111 ASN ASN A . n 
A 1 72  PRO 72  112 112 PRO PRO A . n 
A 1 73  ASP 73  113 113 ASP ASP A . n 
A 1 74  TYR 74  114 114 TYR TYR A . n 
A 1 75  ASP 75  115 115 ASP ASP A . n 
A 1 76  GLU 76  116 116 GLU GLU A . n 
A 1 77  SER 77  117 117 SER SER A . n 
A 1 78  GLY 78  118 118 GLY GLY A . n 
A 1 79  GLY 79  119 119 GLY GLY A . n 
A 1 80  PRO 80  120 120 PRO PRO A . n 
A 1 81  ASP 81  121 121 ASP ASP A . n 
A 1 82  ASN 82  122 122 ASN ASN A . n 
A 1 83  GLU 83  123 123 GLU GLU A . n 
A 1 84  ASP 84  124 124 ASP ASP A . n 
A 1 85  TYR 85  125 125 TYR TYR A . n 
A 1 86  PRO 86  126 126 PRO PRO A . n 
A 1 87  LEU 87  127 127 LEU LEU A . n 
A 1 88  PHE 88  128 128 PHE PHE A . n 
A 1 89  ARG 89  129 129 ARG ARG A . n 
A 1 90  GLU 90  130 130 GLU GLU A . n 
A 1 91  LEU 91  131 131 LEU LEU A . n 
A 1 92  TRP 92  132 132 TRP TRP A . n 
A 1 93  ARG 93  133 133 ARG ARG A . n 
A 1 94  TYR 94  134 134 TYR TYR A . n 
A 1 95  HIS 95  135 135 HIS HIS A . n 
A 1 96  PHE 96  136 136 PHE PHE A . n 
A 1 97  ALA 97  137 137 ALA ALA A . n 
A 1 98  THR 98  138 138 THR THR A . n 
A 1 99  GLY 99  139 139 GLY GLY A . n 
A 1 100 VAL 100 140 140 VAL VAL A . n 
A 1 101 TRP 101 141 141 TRP TRP A . n 
A 1 102 HIS 102 142 142 HIS HIS A . n 
A 1 103 GLN 103 143 143 GLN GLN A . n 
A 1 104 MET 104 144 144 MET MET A . n 
A 1 105 GLY 105 145 145 GLY GLY A . n 
A 1 106 THR 106 146 146 THR THR A . n 
A 1 107 ASP 107 147 147 ASP ASP A . n 
A 1 108 GLY 108 148 148 GLY GLY A . n 
A 1 109 TYR 109 149 149 TYR TYR A . n 
A 1 110 MET 110 150 150 MET MET A . n 
A 1 111 PRO 111 151 151 PRO PRO A . n 
A 1 112 ARG 112 152 152 ARG ARG A . n 
A 1 113 GLU 113 153 153 GLU GLU A . n 
A 1 114 LEU 114 154 154 LEU LEU A . n 
A 1 115 ALA 115 155 155 ALA ALA A . n 
A 1 116 SER 116 156 156 SER SER A . n 
A 1 117 MET 117 157 157 MET MET A . n 
A 1 118 SER 118 158 158 SER SER A . n 
A 1 119 LEU 119 159 159 LEU LEU A . n 
A 1 120 VAL 120 160 160 VAL VAL A . n 
A 1 121 LEU 121 161 161 LEU LEU A . n 
A 1 122 HIS 122 162 162 HIS HIS A . n 
A 1 123 GLY 123 163 163 GLY GLY A . n 
A 1 124 ASN 124 164 164 ASN ASN A . n 
A 1 125 ASN 125 165 165 ASN ASN A . n 
A 1 126 LEU 126 166 166 LEU LEU A . n 
A 1 127 LEU 127 167 167 LEU LEU A . n 
A 1 128 VAL 128 168 168 VAL VAL A . n 
A 1 129 PHE 129 169 169 PHE PHE A . n 
A 1 130 GLY 130 170 170 GLY GLY A . n 
A 1 131 GLY 131 171 171 GLY GLY A . n 
A 1 132 THR 132 172 172 THR THR A . n 
A 1 133 GLY 133 173 173 GLY GLY A . n 
A 1 134 ILE 134 174 174 ILE ILE A . n 
A 1 135 PRO 135 175 175 PRO PRO A . n 
A 1 136 PHE 136 176 176 PHE PHE A . n 
A 1 137 GLY 137 177 177 GLY GLY A . n 
A 1 138 GLU 138 178 178 GLU GLU A . n 
A 1 139 SER 139 179 179 SER SER A . n 
A 1 140 ASN 140 180 180 ASN ASN A . n 
A 1 141 GLY 141 181 181 GLY GLY A . n 
A 1 142 ASN 142 182 182 ASN ASN A . n 
A 1 143 ASP 143 183 183 ASP ASP A . n 
A 1 144 VAL 144 184 184 VAL VAL A . n 
A 1 145 HIS 145 185 185 HIS HIS A . n 
A 1 146 VAL 146 186 186 VAL VAL A . n 
A 1 147 CYS 147 187 187 CYS CYS A . n 
A 1 148 ASN 148 188 188 ASN ASN A . n 
A 1 149 VAL 149 189 189 VAL VAL A . n 
A 1 150 LYS 150 190 190 LYS LYS A . n 
A 1 151 TYR 151 191 191 TYR TYR A . n 
A 1 152 LYS 152 192 192 LYS LYS A . n 
A 1 153 ARG 153 193 193 ARG ARG A . n 
A 1 154 TRP 154 194 194 TRP TRP A . n 
A 1 155 ALA 155 195 195 ALA ALA A . n 
A 1 156 LEU 156 196 196 LEU LEU A . n 
A 1 157 LEU 157 197 197 LEU LEU A . n 
A 1 158 SER 158 198 198 SER SER A . n 
A 1 159 CYS 159 199 199 CYS CYS A . n 
A 1 160 ARG 160 200 200 ARG ARG A . n 
A 1 161 GLY 161 201 201 GLY GLY A . n 
A 1 162 LYS 162 202 202 LYS LYS A . n 
A 1 163 LYS 163 203 203 LYS LYS A . n 
A 1 164 PRO 164 204 204 PRO PRO A . n 
A 1 165 SER 165 205 205 SER SER A . n 
A 1 166 ARG 166 206 206 ARG ARG A . n 
A 1 167 ILE 167 207 207 ILE ILE A . n 
A 1 168 TYR 168 208 208 TYR TYR A . n 
A 1 169 GLY 169 209 209 GLY GLY A . n 
A 1 170 GLN 170 210 210 GLN GLN A . n 
A 1 171 ALA 171 211 211 ALA ALA A . n 
A 1 172 MET 172 212 212 MET MET A . n 
A 1 173 ALA 173 213 213 ALA ALA A . n 
A 1 174 ILE 174 214 214 ILE ILE A . n 
A 1 175 ILE 175 215 215 ILE ILE A . n 
A 1 176 ASN 176 216 216 ASN ASN A . n 
A 1 177 GLY 177 217 217 GLY GLY A . n 
A 1 178 SER 178 218 218 SER SER A . n 
A 1 179 LEU 179 219 219 LEU LEU A . n 
A 1 180 TYR 180 220 220 TYR TYR A . n 
A 1 181 VAL 181 221 221 VAL VAL A . n 
A 1 182 PHE 182 222 222 PHE PHE A . n 
A 1 183 GLY 183 223 223 GLY GLY A . n 
A 1 184 GLY 184 224 224 GLY GLY A . n 
A 1 185 THR 185 225 225 THR THR A . n 
A 1 186 THR 186 226 226 THR THR A . n 
A 1 187 GLY 187 227 227 GLY GLY A . n 
A 1 188 TYR 188 228 228 TYR TYR A . n 
A 1 189 ILE 189 229 229 ILE ILE A . n 
A 1 190 TYR 190 230 230 TYR TYR A . n 
A 1 191 SER 191 231 231 SER SER A . n 
A 1 192 THR 192 232 232 THR THR A . n 
A 1 193 ASP 193 233 233 ASP ASP A . n 
A 1 194 LEU 194 234 234 LEU LEU A . n 
A 1 195 HIS 195 235 235 HIS HIS A . n 
A 1 196 LYS 196 236 236 LYS LYS A . n 
A 1 197 LEU 197 237 237 LEU LEU A . n 
A 1 198 ASP 198 238 238 ASP ASP A . n 
A 1 199 LEU 199 239 239 LEU LEU A . n 
A 1 200 ASN 200 240 240 ASN ASN A . n 
A 1 201 THR 201 241 241 THR THR A . n 
A 1 202 ARG 202 242 242 ARG ARG A . n 
A 1 203 GLU 203 243 243 GLU GLU A . n 
A 1 204 TRP 204 244 244 TRP TRP A . n 
A 1 205 THR 205 245 245 THR THR A . n 
A 1 206 GLN 206 246 246 GLN GLN A . n 
A 1 207 LEU 207 247 247 LEU LEU A . n 
A 1 208 LYS 208 248 248 LYS LYS A . n 
A 1 209 PRO 209 249 249 PRO PRO A . n 
A 1 210 ASN 210 250 ?   ?   ?   A . n 
A 1 211 ASN 211 251 ?   ?   ?   A . n 
A 1 212 LEU 212 252 ?   ?   ?   A . n 
A 1 213 SER 213 253 ?   ?   ?   A . n 
A 1 214 CYS 214 254 ?   ?   ?   A . n 
A 1 215 ASP 215 255 ?   ?   ?   A . n 
A 1 216 LEU 216 256 256 LEU LEU A . n 
A 1 217 PRO 217 257 257 PRO PRO A . n 
A 1 218 GLU 218 258 258 GLU GLU A . n 
A 1 219 GLU 219 259 259 GLU GLU A . n 
A 1 220 ARG 220 260 260 ARG ARG A . n 
A 1 221 TYR 221 261 261 TYR TYR A . n 
A 1 222 ARG 222 262 262 ARG ARG A . n 
A 1 223 HIS 223 263 263 HIS HIS A . n 
A 1 224 GLU 224 264 264 GLU GLU A . n 
A 1 225 ILE 225 265 265 ILE ILE A . n 
A 1 226 ALA 226 266 266 ALA ALA A . n 
A 1 227 HIS 227 267 267 HIS HIS A . n 
A 1 228 ASP 228 268 268 ASP ASP A . n 
A 1 229 GLY 229 269 269 GLY GLY A . n 
A 1 230 GLN 230 270 270 GLN GLN A . n 
A 1 231 ARG 231 271 271 ARG ARG A . n 
A 1 232 ILE 232 272 272 ILE ILE A . n 
A 1 233 TYR 233 273 273 TYR TYR A . n 
A 1 234 ILE 234 274 274 ILE ILE A . n 
A 1 235 LEU 235 275 275 LEU LEU A . n 
A 1 236 GLY 236 276 276 GLY GLY A . n 
A 1 237 GLY 237 277 277 GLY GLY A . n 
A 1 238 GLY 238 278 278 GLY GLY A . n 
A 1 239 THR 239 279 279 THR THR A . n 
A 1 240 SER 240 280 280 SER SER A . n 
A 1 241 TRP 241 281 281 TRP TRP A . n 
A 1 242 THR 242 282 282 THR THR A . n 
A 1 243 ALA 243 283 283 ALA ALA A . n 
A 1 244 TYR 244 284 284 TYR TYR A . n 
A 1 245 SER 245 285 285 SER SER A . n 
A 1 246 LEU 246 286 286 LEU LEU A . n 
A 1 247 ASN 247 287 287 ASN ASN A . n 
A 1 248 LYS 248 288 288 LYS LYS A . n 
A 1 249 ILE 249 289 289 ILE ILE A . n 
A 1 250 HIS 250 290 290 HIS HIS A . n 
A 1 251 ALA 251 291 291 ALA ALA A . n 
A 1 252 TYR 252 292 292 TYR TYR A . n 
A 1 253 ASN 253 293 293 ASN ASN A . n 
A 1 254 LEU 254 294 294 LEU LEU A . n 
A 1 255 GLU 255 295 295 GLU GLU A . n 
A 1 256 THR 256 296 296 THR THR A . n 
A 1 257 ASN 257 297 297 ASN ASN A . n 
A 1 258 ALA 258 298 298 ALA ALA A . n 
A 1 259 TRP 259 299 299 TRP TRP A . n 
A 1 260 GLU 260 300 300 GLU GLU A . n 
A 1 261 GLU 261 301 301 GLU GLU A . n 
A 1 262 ILE 262 302 302 ILE ILE A . n 
A 1 263 ALA 263 303 303 ALA ALA A . n 
A 1 264 THR 264 304 304 THR THR A . n 
A 1 265 LYS 265 305 305 LYS LYS A . n 
A 1 266 PRO 266 306 306 PRO PRO A . n 
A 1 267 HIS 267 307 307 HIS HIS A . n 
A 1 268 GLU 268 308 308 GLU GLU A . n 
A 1 269 LYS 269 309 309 LYS LYS A . n 
A 1 270 ILE 270 310 310 ILE ILE A . n 
A 1 271 GLY 271 311 311 GLY GLY A . n 
A 1 272 PHE 272 312 312 PHE PHE A . n 
A 1 273 PRO 273 313 313 PRO PRO A . n 
A 1 274 ALA 274 314 314 ALA ALA A . n 
A 1 275 ALA 275 315 315 ALA ALA A . n 
A 1 276 ARG 276 316 316 ARG ARG A . n 
A 1 277 ARG 277 317 317 ARG ARG A . n 
A 1 278 CYS 278 318 318 CYS CYS A . n 
A 1 279 HIS 279 319 319 HIS HIS A . n 
A 1 280 SER 280 320 320 SER SER A . n 
A 1 281 CYS 281 321 321 CYS CYS A . n 
A 1 282 VAL 282 322 322 VAL VAL A . n 
A 1 283 GLN 283 323 323 GLN GLN A . n 
A 1 284 ILE 284 324 324 ILE ILE A . n 
A 1 285 LYS 285 325 325 LYS LYS A . n 
A 1 286 ASN 286 326 326 ASN ASN A . n 
A 1 287 ASP 287 327 327 ASP ASP A . n 
A 1 288 VAL 288 328 328 VAL VAL A . n 
A 1 289 PHE 289 329 329 PHE PHE A . n 
A 1 290 ILE 290 330 330 ILE ILE A . n 
A 1 291 CYS 291 331 331 CYS CYS A . n 
A 1 292 GLY 292 332 332 GLY GLY A . n 
A 1 293 GLY 293 333 333 GLY GLY A . n 
A 1 294 TYR 294 334 334 TYR TYR A . n 
A 1 295 ASN 295 335 335 ASN ASN A . n 
A 1 296 GLY 296 336 336 GLY GLY A . n 
A 1 297 GLU 297 337 337 GLU GLU A . n 
A 1 298 VAL 298 338 338 VAL VAL A . n 
A 1 299 ILE 299 339 339 ILE ILE A . n 
A 1 300 LEU 300 340 340 LEU LEU A . n 
A 1 301 GLY 301 341 341 GLY GLY A . n 
A 1 302 ASP 302 342 342 ASP ASP A . n 
A 1 303 ILE 303 343 343 ILE ILE A . n 
A 1 304 TRP 304 344 344 TRP TRP A . n 
A 1 305 LYS 305 345 345 LYS LYS A . n 
A 1 306 LEU 306 346 346 LEU LEU A . n 
A 1 307 ASN 307 347 347 ASN ASN A . n 
A 1 308 LEU 308 348 348 LEU LEU A . n 
A 1 309 GLN 309 349 349 GLN GLN A . n 
A 1 310 THR 310 350 350 THR THR A . n 
A 1 311 PHE 311 351 351 PHE PHE A . n 
A 1 312 GLN 312 352 352 GLN GLN A . n 
A 1 313 TRP 313 353 353 TRP TRP A . n 
A 1 314 VAL 314 354 354 VAL VAL A . n 
A 1 315 LYS 315 355 355 LYS LYS A . n 
A 1 316 LEU 316 356 356 LEU LEU A . n 
A 1 317 PRO 317 357 357 PRO PRO A . n 
A 1 318 ALA 318 358 358 ALA ALA A . n 
A 1 319 THR 319 359 359 THR THR A . n 
A 1 320 MET 320 360 360 MET MET A . n 
A 1 321 PRO 321 361 361 PRO PRO A . n 
A 1 322 GLU 322 362 362 GLU GLU A . n 
A 1 323 PRO 323 363 363 PRO PRO A . n 
A 1 324 VAL 324 364 364 VAL VAL A . n 
A 1 325 TYR 325 365 365 TYR TYR A . n 
A 1 326 PHE 326 366 366 PHE PHE A . n 
A 1 327 HIS 327 367 367 HIS HIS A . n 
A 1 328 CYS 328 368 368 CYS CYS A . n 
A 1 329 ALA 329 369 369 ALA ALA A . n 
A 1 330 ALA 330 370 370 ALA ALA A . n 
A 1 331 VAL 331 371 371 VAL VAL A . n 
A 1 332 THR 332 372 372 THR THR A . n 
A 1 333 PRO 333 373 373 PRO PRO A . n 
A 1 334 ALA 334 374 374 ALA ALA A . n 
A 1 335 GLY 335 375 375 GLY GLY A . n 
A 1 336 CYS 336 376 376 CYS CYS A . n 
A 1 337 MET 337 377 377 MET MET A . n 
A 1 338 TYR 338 378 378 TYR TYR A . n 
A 1 339 ILE 339 379 379 ILE ILE A . n 
A 1 340 HIS 340 380 380 HIS HIS A . n 
A 1 341 GLY 341 381 381 GLY GLY A . n 
A 1 342 GLY 342 382 382 GLY GLY A . n 
A 1 343 VAL 343 383 383 VAL VAL A . n 
A 1 344 VAL 344 384 384 VAL VAL A . n 
A 1 345 ASN 345 385 385 ASN ASN A . n 
A 1 346 ILE 346 386 386 ILE ILE A . n 
A 1 347 HIS 347 387 387 HIS HIS A . n 
A 1 348 GLU 348 388 388 GLU GLU A . n 
A 1 349 ASN 349 389 389 ASN ASN A . n 
A 1 350 LYS 350 390 390 LYS LYS A . n 
A 1 351 ARG 351 391 391 ARG ARG A . n 
A 1 352 THR 352 392 392 THR THR A . n 
A 1 353 GLY 353 393 393 GLY GLY A . n 
A 1 354 SER 354 394 394 SER SER A . n 
A 1 355 LEU 355 395 395 LEU LEU A . n 
A 1 356 PHE 356 396 396 PHE PHE A . n 
A 1 357 LYS 357 397 397 LYS LYS A . n 
A 1 358 ILE 358 398 398 ILE ILE A . n 
A 1 359 TRP 359 399 399 TRP TRP A . n 
A 1 360 LEU 360 400 400 LEU LEU A . n 
A 1 361 VAL 361 401 401 VAL VAL A . n 
A 1 362 VAL 362 402 402 VAL VAL A . n 
A 1 363 PRO 363 403 403 PRO PRO A . n 
A 1 364 SER 364 404 404 SER SER A . n 
A 1 365 LEU 365 405 405 LEU LEU A . n 
A 1 366 LEU 366 406 406 LEU LEU A . n 
A 1 367 GLU 367 407 407 GLU GLU A . n 
A 1 368 LEU 368 408 408 LEU LEU A . n 
A 1 369 ALA 369 409 409 ALA ALA A . n 
A 1 370 TRP 370 410 410 TRP TRP A . n 
A 1 371 GLU 371 411 411 GLU GLU A . n 
A 1 372 LYS 372 412 412 LYS LYS A . n 
A 1 373 LEU 373 413 413 LEU LEU A . n 
A 1 374 LEU 374 414 414 LEU LEU A . n 
A 1 375 ALA 375 415 415 ALA ALA A . n 
A 1 376 ALA 376 416 416 ALA ALA A . n 
A 1 377 PHE 377 417 417 PHE PHE A . n 
A 1 378 PRO 378 418 418 PRO PRO A . n 
A 1 379 ASN 379 419 419 ASN ASN A . n 
A 1 380 LEU 380 420 420 LEU LEU A . n 
A 1 381 ALA 381 421 421 ALA ALA A . n 
A 1 382 ASN 382 422 422 ASN ASN A . n 
A 1 383 LEU 383 423 423 LEU LEU A . n 
A 1 384 SER 384 424 424 SER SER A . n 
A 1 385 ARG 385 425 425 ARG ARG A . n 
A 1 386 THR 386 426 426 THR THR A . n 
A 1 387 GLN 387 427 427 GLN GLN A . n 
A 1 388 LEU 388 428 428 LEU LEU A . n 
A 1 389 LEU 389 429 429 LEU LEU A . n 
A 1 390 HIS 390 430 430 HIS HIS A . n 
A 1 391 LEU 391 431 431 LEU LEU A . n 
A 1 392 GLY 392 432 432 GLY GLY A . n 
A 1 393 LEU 393 433 433 LEU LEU A . n 
A 1 394 THR 394 434 434 THR THR A . n 
A 1 395 GLN 395 435 435 GLN GLN A . n 
A 1 396 GLY 396 436 436 GLY GLY A . n 
A 1 397 LEU 397 437 437 LEU LEU A . n 
A 1 398 ILE 398 438 438 ILE ILE A . n 
A 1 399 GLU 399 439 439 GLU GLU A . n 
A 1 400 ARG 400 440 440 ARG ARG A . n 
A 1 401 LEU 401 441 441 LEU LEU A . n 
A 1 402 LYS 402 442 442 LYS LYS A . n 
B 2 1   MET 1   1   ?   ?   ?   B . n 
B 2 2   ASP 2   2   2   ASP ASP B . n 
B 2 3   VAL 3   3   3   VAL VAL B . n 
B 2 4   PHE 4   4   4   PHE PHE B . n 
B 2 5   LEU 5   5   5   LEU LEU B . n 
B 2 6   MET 6   6   6   MET MET B . n 
B 2 7   ILE 7   7   7   ILE ILE B . n 
B 2 8   ARG 8   8   8   ARG ARG B . n 
B 2 9   ARG 9   9   9   ARG ARG B . n 
B 2 10  HIS 10  10  10  HIS HIS B . n 
B 2 11  LYS 11  11  11  LYS LYS B . n 
B 2 12  THR 12  12  12  THR THR B . n 
B 2 13  THR 13  13  13  THR THR B . n 
B 2 14  ILE 14  14  14  ILE ILE B . n 
B 2 15  PHE 15  15  15  PHE PHE B . n 
B 2 16  THR 16  16  16  THR THR B . n 
B 2 17  ASP 17  17  17  ASP ASP B . n 
B 2 18  ALA 18  18  18  ALA ALA B . n 
B 2 19  LYS 19  19  19  LYS LYS B . n 
B 2 20  GLU 20  20  20  GLU GLU B . n 
B 2 21  SER 21  21  21  SER SER B . n 
B 2 22  SER 22  22  22  SER SER B . n 
B 2 23  THR 23  23  23  THR THR B . n 
B 2 24  VAL 24  24  24  VAL VAL B . n 
B 2 25  PHE 25  25  25  PHE PHE B . n 
B 2 26  GLU 26  26  26  GLU GLU B . n 
B 2 27  LEU 27  27  27  LEU LEU B . n 
B 2 28  LYS 28  28  28  LYS LYS B . n 
B 2 29  ARG 29  29  29  ARG ARG B . n 
B 2 30  ILE 30  30  30  ILE ILE B . n 
B 2 31  VAL 31  31  31  VAL VAL B . n 
B 2 32  GLU 32  32  32  GLU GLU B . n 
B 2 33  GLY 33  33  33  GLY GLY B . n 
B 2 34  ILE 34  34  34  ILE ILE B . n 
B 2 35  LEU 35  35  35  LEU LEU B . n 
B 2 36  LYS 36  36  36  LYS LYS B . n 
B 2 37  ARG 37  37  37  ARG ARG B . n 
B 2 38  PRO 38  38  38  PRO PRO B . n 
B 2 39  PRO 39  39  39  PRO PRO B . n 
B 2 40  ASP 40  40  40  ASP ASP B . n 
B 2 41  GLU 41  41  41  GLU GLU B . n 
B 2 42  GLN 42  42  42  GLN GLN B . n 
B 2 43  ARG 43  43  43  ARG ARG B . n 
B 2 44  LEU 44  44  44  LEU LEU B . n 
B 2 45  TYR 45  45  45  TYR TYR B . n 
B 2 46  LYS 46  46  ?   ?   ?   B . n 
B 2 47  ASP 47  47  ?   ?   ?   B . n 
B 2 48  ASP 48  48  ?   ?   ?   B . n 
B 2 49  GLN 49  49  ?   ?   ?   B . n 
B 2 50  LEU 50  50  ?   ?   ?   B . n 
B 2 51  LEU 51  51  ?   ?   ?   B . n 
B 2 52  ASP 52  52  ?   ?   ?   B . n 
B 2 53  ASP 53  53  53  ASP ASP B . n 
B 2 54  GLY 54  54  54  GLY GLY B . n 
B 2 55  LYS 55  55  55  LYS LYS B . n 
B 2 56  THR 56  56  56  THR THR B . n 
B 2 57  LEU 57  57  57  LEU LEU B . n 
B 2 58  GLY 58  58  58  GLY GLY B . n 
B 2 59  GLU 59  59  59  GLU GLU B . n 
B 2 60  CYS 60  60  60  CYS CYS B . n 
B 2 61  GLY 61  61  61  GLY GLY B . n 
B 2 62  PHE 62  62  62  PHE PHE B . n 
B 2 63  THR 63  63  63  THR THR B . n 
B 2 64  SER 64  64  64  SER SER B . n 
B 2 65  GLN 65  65  65  GLN GLN B . n 
B 2 66  THR 66  66  66  THR THR B . n 
B 2 67  ALA 67  67  67  ALA ALA B . n 
B 2 68  ARG 68  68  68  ARG ARG B . n 
B 2 69  PRO 69  69  69  PRO PRO B . n 
B 2 70  GLN 70  70  70  GLN GLN B . n 
B 2 71  ALA 71  71  71  ALA ALA B . n 
B 2 72  PRO 72  72  72  PRO PRO B . n 
B 2 73  ALA 73  73  73  ALA ALA B . n 
B 2 74  THR 74  74  74  THR THR B . n 
B 2 75  VAL 75  75  75  VAL VAL B . n 
B 2 76  GLY 76  76  76  GLY GLY B . n 
B 2 77  LEU 77  77  77  LEU LEU B . n 
B 2 78  ALA 78  78  78  ALA ALA B . n 
B 2 79  PHE 79  79  79  PHE PHE B . n 
B 2 80  ARG 80  80  ?   ?   ?   B . n 
B 2 81  ALA 81  81  ?   ?   ?   B . n 
B 2 82  ASP 82  82  ?   ?   ?   B . n 
B 2 83  ASP 83  83  ?   ?   ?   B . n 
B 2 84  THR 84  84  ?   ?   ?   B . n 
B 2 85  PHE 85  85  ?   ?   ?   B . n 
B 2 86  GLU 86  86  86  GLU GLU B . n 
B 2 87  ALA 87  87  87  ALA ALA B . n 
B 2 88  LEU 88  88  88  LEU LEU B . n 
B 2 89  CYS 89  89  89  CYS CYS B . n 
B 2 90  ILE 90  90  90  ILE ILE B . n 
B 2 91  GLU 91  91  91  GLU GLU B . n 
B 2 92  PRO 92  92  92  PRO PRO B . n 
B 2 93  PHE 93  93  93  PHE PHE B . n 
B 2 94  SER 94  94  94  SER SER B . n 
B 2 95  SER 95  95  95  SER SER B . n 
B 2 96  PRO 96  96  96  PRO PRO B . n 
B 2 97  PRO 97  97  97  PRO PRO B . n 
B 2 98  GLU 98  98  98  GLU GLU B . n 
B 2 99  LEU 99  99  99  LEU LEU B . n 
B 2 100 PRO 100 100 100 PRO PRO B . n 
B 2 101 ASP 101 101 101 ASP ASP B . n 
B 2 102 VAL 102 102 102 VAL VAL B . n 
B 2 103 MET 103 103 ?   ?   ?   B . n 
B 2 104 LYS 104 104 ?   ?   ?   B . n 
B 2 105 PRO 105 105 ?   ?   ?   B . n 
B 2 106 GLN 106 106 ?   ?   ?   B . n 
B 2 107 ASP 107 107 ?   ?   ?   B . n 
B 2 108 SER 108 108 ?   ?   ?   B . n 
B 2 109 GLY 109 109 ?   ?   ?   B . n 
B 2 110 SER 110 110 ?   ?   ?   B . n 
B 2 111 SER 111 111 ?   ?   ?   B . n 
B 2 112 ALA 112 112 ?   ?   ?   B . n 
B 2 113 ASN 113 113 ?   ?   ?   B . n 
B 2 114 GLU 114 114 ?   ?   ?   B . n 
B 2 115 GLN 115 115 ?   ?   ?   B . n 
B 2 116 ALA 116 116 ?   ?   ?   B . n 
B 2 117 VAL 117 117 ?   ?   ?   B . n 
B 2 118 GLN 118 118 ?   ?   ?   B . n 
C 3 1   MET 1   1   ?   ?   ?   C . n 
C 3 2   ASP 2   2   ?   ?   ?   C . n 
C 3 3   GLY 3   3   ?   ?   ?   C . n 
C 3 4   GLU 4   4   ?   ?   ?   C . n 
C 3 5   GLU 5   5   ?   ?   ?   C . n 
C 3 6   LYS 6   6   ?   ?   ?   C . n 
C 3 7   THR 7   7   ?   ?   ?   C . n 
C 3 8   TYR 8   8   ?   ?   ?   C . n 
C 3 9   GLY 9   9   ?   ?   ?   C . n 
C 3 10  GLY 10  10  ?   ?   ?   C . n 
C 3 11  CYS 11  11  ?   ?   ?   C . n 
C 3 12  GLU 12  12  ?   ?   ?   C . n 
C 3 13  GLY 13  13  ?   ?   ?   C . n 
C 3 14  PRO 14  14  ?   ?   ?   C . n 
C 3 15  ASP 15  15  ?   ?   ?   C . n 
C 3 16  ALA 16  16  ?   ?   ?   C . n 
C 3 17  MET 17  17  17  MET MET C . n 
C 3 18  TYR 18  18  18  TYR TYR C . n 
C 3 19  VAL 19  19  19  VAL VAL C . n 
C 3 20  LYS 20  20  20  LYS LYS C . n 
C 3 21  LEU 21  21  21  LEU LEU C . n 
C 3 22  ILE 22  22  22  ILE ILE C . n 
C 3 23  SER 23  23  23  SER SER C . n 
C 3 24  SER 24  24  24  SER SER C . n 
C 3 25  ASP 25  25  25  ASP ASP C . n 
C 3 26  GLY 26  26  26  GLY GLY C . n 
C 3 27  HIS 27  27  27  HIS HIS C . n 
C 3 28  GLU 28  28  28  GLU GLU C . n 
C 3 29  PHE 29  29  29  PHE PHE C . n 
C 3 30  ILE 30  30  30  ILE ILE C . n 
C 3 31  VAL 31  31  31  VAL VAL C . n 
C 3 32  LYS 32  32  32  LYS LYS C . n 
C 3 33  ARG 33  33  33  ARG ARG C . n 
C 3 34  GLU 34  34  34  GLU GLU C . n 
C 3 35  HIS 35  35  35  HIS HIS C . n 
C 3 36  ALA 36  36  36  ALA ALA C . n 
C 3 37  LEU 37  37  37  LEU LEU C . n 
C 3 38  THR 38  38  38  THR THR C . n 
C 3 39  SER 39  39  39  SER SER C . n 
C 3 40  GLY 40  40  40  GLY GLY C . n 
C 3 41  THR 41  41  41  THR THR C . n 
C 3 42  ILE 42  42  42  ILE ILE C . n 
C 3 43  LYS 43  43  43  LYS LYS C . n 
C 3 44  ALA 44  44  44  ALA ALA C . n 
C 3 45  MET 45  45  45  MET MET C . n 
C 3 46  LEU 46  46  46  LEU LEU C . n 
C 3 47  SER 47  47  ?   ?   ?   C . n 
C 3 48  GLY 48  48  ?   ?   ?   C . n 
C 3 49  PRO 49  49  ?   ?   ?   C . n 
C 3 50  GLY 50  50  ?   ?   ?   C . n 
C 3 51  GLN 51  51  ?   ?   ?   C . n 
C 3 52  PHE 52  52  ?   ?   ?   C . n 
C 3 53  ALA 53  53  ?   ?   ?   C . n 
C 3 54  GLU 54  54  ?   ?   ?   C . n 
C 3 55  ASN 55  55  ?   ?   ?   C . n 
C 3 56  GLU 56  56  ?   ?   ?   C . n 
C 3 57  THR 57  57  ?   ?   ?   C . n 
C 3 58  ASN 58  58  58  ASN ASN C . n 
C 3 59  GLU 59  59  59  GLU GLU C . n 
C 3 60  VAL 60  60  60  VAL VAL C . n 
C 3 61  ASN 61  61  61  ASN ASN C . n 
C 3 62  PHE 62  62  62  PHE PHE C . n 
C 3 63  ARG 63  63  63  ARG ARG C . n 
C 3 64  GLU 64  64  64  GLU GLU C . n 
C 3 65  ILE 65  65  65  ILE ILE C . n 
C 3 66  PRO 66  66  66  PRO PRO C . n 
C 3 67  SER 67  67  67  SER SER C . n 
C 3 68  HIS 68  68  68  HIS HIS C . n 
C 3 69  VAL 69  69  69  VAL VAL C . n 
C 3 70  LEU 70  70  70  LEU LEU C . n 
C 3 71  SER 71  71  71  SER SER C . n 
C 3 72  LYS 72  72  72  LYS LYS C . n 
C 3 73  VAL 73  73  73  VAL VAL C . n 
C 3 74  CYS 74  74  74  CYS CYS C . n 
C 3 75  MET 75  75  75  MET MET C . n 
C 3 76  TYR 76  76  76  TYR TYR C . n 
C 3 77  PHE 77  77  77  PHE PHE C . n 
C 3 78  THR 78  78  78  THR THR C . n 
C 3 79  TYR 79  79  79  TYR TYR C . n 
C 3 80  LYS 80  80  80  LYS LYS C . n 
C 3 81  VAL 81  81  81  VAL VAL C . n 
C 3 82  ARG 82  82  82  ARG ARG C . n 
C 3 83  TYR 83  83  83  TYR TYR C . n 
C 3 84  THR 84  84  84  THR THR C . n 
C 3 85  ASN 85  85  85  ASN ASN C . n 
C 3 86  SER 86  86  86  SER SER C . n 
C 3 87  SER 87  87  87  SER SER C . n 
C 3 88  THR 88  88  88  THR THR C . n 
C 3 89  GLU 89  89  89  GLU GLU C . n 
C 3 90  ILE 90  90  90  ILE ILE C . n 
C 3 91  PRO 91  91  91  PRO PRO C . n 
C 3 92  GLU 92  92  92  GLU GLU C . n 
C 3 93  PHE 93  93  93  PHE PHE C . n 
C 3 94  PRO 94  94  94  PRO PRO C . n 
C 3 95  ILE 95  95  95  ILE ILE C . n 
C 3 96  ALA 96  96  96  ALA ALA C . n 
C 3 97  PRO 97  97  97  PRO PRO C . n 
C 3 98  GLU 98  98  98  GLU GLU C . n 
C 3 99  ILE 99  99  99  ILE ILE C . n 
C 3 100 ALA 100 100 100 ALA ALA C . n 
C 3 101 LEU 101 101 101 LEU LEU C . n 
C 3 102 GLU 102 102 102 GLU GLU C . n 
C 3 103 LEU 103 103 103 LEU LEU C . n 
C 3 104 LEU 104 104 104 LEU LEU C . n 
C 3 105 MET 105 105 105 MET MET C . n 
C 3 106 ALA 106 106 106 ALA ALA C . n 
C 3 107 ALA 107 107 107 ALA ALA C . n 
C 3 108 ASN 108 108 108 ASN ASN C . n 
C 3 109 PHE 109 109 109 PHE PHE C . n 
C 3 110 LEU 110 110 110 LEU LEU C . n 
C 3 111 ASP 111 111 111 ASP ASP C . n 
C 3 112 CYS 112 112 112 CYS CYS C . n 
D 4 1   MET 1   1   ?   ?   ?   D . n 
D 4 2   GLN 2   2   ?   ?   ?   D . n 
D 4 3   ILE 3   3   ?   ?   ?   D . n 
D 4 4   PHE 4   4   ?   ?   ?   D . n 
D 4 5   VAL 5   5   ?   ?   ?   D . n 
D 4 6   LYS 6   6   ?   ?   ?   D . n 
D 4 7   THR 7   7   ?   ?   ?   D . n 
D 4 8   LEU 8   8   ?   ?   ?   D . n 
D 4 9   THR 9   9   ?   ?   ?   D . n 
D 4 10  GLY 10  10  ?   ?   ?   D . n 
D 4 11  LYS 11  11  ?   ?   ?   D . n 
D 4 12  THR 12  12  ?   ?   ?   D . n 
D 4 13  ILE 13  13  ?   ?   ?   D . n 
D 4 14  THR 14  14  ?   ?   ?   D . n 
D 4 15  LEU 15  15  ?   ?   ?   D . n 
D 4 16  GLU 16  16  ?   ?   ?   D . n 
D 4 17  VAL 17  17  ?   ?   ?   D . n 
D 4 18  GLU 18  18  ?   ?   ?   D . n 
D 4 19  PRO 19  19  ?   ?   ?   D . n 
D 4 20  SER 20  20  ?   ?   ?   D . n 
D 4 21  ASP 21  21  ?   ?   ?   D . n 
D 4 22  THR 22  22  ?   ?   ?   D . n 
D 4 23  ILE 23  23  ?   ?   ?   D . n 
D 4 24  GLU 24  24  ?   ?   ?   D . n 
D 4 25  ASN 25  25  ?   ?   ?   D . n 
D 4 26  VAL 26  26  ?   ?   ?   D . n 
D 4 27  LYS 27  27  ?   ?   ?   D . n 
D 4 28  ALA 28  28  ?   ?   ?   D . n 
D 4 29  LYS 29  29  ?   ?   ?   D . n 
D 4 30  ILE 30  30  ?   ?   ?   D . n 
D 4 31  GLN 31  31  ?   ?   ?   D . n 
D 4 32  ASP 32  32  ?   ?   ?   D . n 
D 4 33  LYS 33  33  ?   ?   ?   D . n 
D 4 34  GLU 34  34  ?   ?   ?   D . n 
D 4 35  GLY 35  35  ?   ?   ?   D . n 
D 4 36  ILE 36  36  ?   ?   ?   D . n 
D 4 37  PRO 37  37  ?   ?   ?   D . n 
D 4 38  PRO 38  38  ?   ?   ?   D . n 
D 4 39  ASP 39  39  ?   ?   ?   D . n 
D 4 40  GLN 40  40  ?   ?   ?   D . n 
D 4 41  GLN 41  41  ?   ?   ?   D . n 
D 4 42  ARG 42  42  ?   ?   ?   D . n 
D 4 43  LEU 43  43  ?   ?   ?   D . n 
D 4 44  ILE 44  44  ?   ?   ?   D . n 
D 4 45  PHE 45  45  ?   ?   ?   D . n 
D 4 46  ALA 46  46  ?   ?   ?   D . n 
D 4 47  GLY 47  47  ?   ?   ?   D . n 
D 4 48  CYS 48  48  ?   ?   ?   D . n 
D 4 49  GLN 49  49  ?   ?   ?   D . n 
D 4 50  LEU 50  50  ?   ?   ?   D . n 
D 4 51  GLU 51  51  ?   ?   ?   D . n 
D 4 52  ASP 52  52  ?   ?   ?   D . n 
D 4 53  GLY 53  53  ?   ?   ?   D . n 
D 4 54  ARG 54  54  ?   ?   ?   D . n 
D 4 55  THR 55  55  ?   ?   ?   D . n 
D 4 56  LEU 56  56  ?   ?   ?   D . n 
D 4 57  SER 57  57  ?   ?   ?   D . n 
D 4 58  ASP 58  58  ?   ?   ?   D . n 
D 4 59  TYR 59  59  ?   ?   ?   D . n 
D 4 60  ASN 60  60  ?   ?   ?   D . n 
D 4 61  ILE 61  61  ?   ?   ?   D . n 
D 4 62  GLN 62  62  ?   ?   ?   D . n 
D 4 63  LYS 63  63  ?   ?   ?   D . n 
D 4 64  GLU 64  64  ?   ?   ?   D . n 
D 4 65  SER 65  65  ?   ?   ?   D . n 
D 4 66  THR 66  66  ?   ?   ?   D . n 
D 4 67  LEU 67  67  ?   ?   ?   D . n 
D 4 68  HIS 68  68  ?   ?   ?   D . n 
D 4 69  LEU 69  69  ?   ?   ?   D . n 
D 4 70  VAL 70  70  ?   ?   ?   D . n 
D 4 71  LEU 71  71  ?   ?   ?   D . n 
D 4 72  ARG 72  72  ?   ?   ?   D . n 
D 4 73  LEU 73  73  73  LEU LEU D . n 
D 4 74  ARG 74  74  74  ARG ARG D . n 
D 4 75  GLY 75  75  75  GLY GLY D . n 
D 4 76  GLY 76  76  76  GLY GLY D . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A ASP 121 ? CG  ? A ASP 81  CG  
2   1 Y 1 A ASP 121 ? OD1 ? A ASP 81  OD1 
3   1 Y 1 A ASP 121 ? OD2 ? A ASP 81  OD2 
4   1 Y 1 A GLU 123 ? CG  ? A GLU 83  CG  
5   1 Y 1 A GLU 123 ? CD  ? A GLU 83  CD  
6   1 Y 1 A GLU 123 ? OE1 ? A GLU 83  OE1 
7   1 Y 1 A GLU 123 ? OE2 ? A GLU 83  OE2 
8   1 Y 1 A ASP 124 ? CG  ? A ASP 84  CG  
9   1 Y 1 A ASP 124 ? OD1 ? A ASP 84  OD1 
10  1 Y 1 A ASP 124 ? OD2 ? A ASP 84  OD2 
11  1 Y 1 A GLU 178 ? CG  ? A GLU 138 CG  
12  1 Y 1 A GLU 178 ? CD  ? A GLU 138 CD  
13  1 Y 1 A GLU 178 ? OE1 ? A GLU 138 OE1 
14  1 Y 1 A GLU 178 ? OE2 ? A GLU 138 OE2 
15  1 Y 1 A LYS 190 ? CG  ? A LYS 150 CG  
16  1 Y 1 A LYS 190 ? CD  ? A LYS 150 CD  
17  1 Y 1 A LYS 190 ? CE  ? A LYS 150 CE  
18  1 Y 1 A LYS 190 ? NZ  ? A LYS 150 NZ  
19  1 Y 1 A ARG 193 ? CG  ? A ARG 153 CG  
20  1 Y 1 A ARG 193 ? CD  ? A ARG 153 CD  
21  1 Y 1 A ARG 193 ? NE  ? A ARG 153 NE  
22  1 Y 1 A ARG 193 ? CZ  ? A ARG 153 CZ  
23  1 Y 1 A ARG 193 ? NH1 ? A ARG 153 NH1 
24  1 Y 1 A ARG 193 ? NH2 ? A ARG 153 NH2 
25  1 Y 1 A ARG 200 ? CG  ? A ARG 160 CG  
26  1 Y 1 A ARG 200 ? CD  ? A ARG 160 CD  
27  1 Y 1 A ARG 200 ? NE  ? A ARG 160 NE  
28  1 Y 1 A ARG 200 ? CZ  ? A ARG 160 CZ  
29  1 Y 1 A ARG 200 ? NH1 ? A ARG 160 NH1 
30  1 Y 1 A ARG 200 ? NH2 ? A ARG 160 NH2 
31  1 Y 1 A ASN 216 ? CG  ? A ASN 176 CG  
32  1 Y 1 A ASN 216 ? OD1 ? A ASN 176 OD1 
33  1 Y 1 A ASN 216 ? ND2 ? A ASN 176 ND2 
34  1 Y 1 A TYR 228 ? CG  ? A TYR 188 CG  
35  1 Y 1 A TYR 228 ? CD1 ? A TYR 188 CD1 
36  1 Y 1 A TYR 228 ? CD2 ? A TYR 188 CD2 
37  1 Y 1 A TYR 228 ? CE1 ? A TYR 188 CE1 
38  1 Y 1 A TYR 228 ? CE2 ? A TYR 188 CE2 
39  1 Y 1 A TYR 228 ? CZ  ? A TYR 188 CZ  
40  1 Y 1 A TYR 228 ? OH  ? A TYR 188 OH  
41  1 Y 1 A ASP 238 ? CG  ? A ASP 198 CG  
42  1 Y 1 A ASP 238 ? OD1 ? A ASP 198 OD1 
43  1 Y 1 A ASP 238 ? OD2 ? A ASP 198 OD2 
44  1 Y 1 A LYS 248 ? CG  ? A LYS 208 CG  
45  1 Y 1 A LYS 248 ? CD  ? A LYS 208 CD  
46  1 Y 1 A LYS 248 ? CE  ? A LYS 208 CE  
47  1 Y 1 A LYS 248 ? NZ  ? A LYS 208 NZ  
48  1 Y 1 A GLN 270 ? CG  ? A GLN 230 CG  
49  1 Y 1 A GLN 270 ? CD  ? A GLN 230 CD  
50  1 Y 1 A GLN 270 ? OE1 ? A GLN 230 OE1 
51  1 Y 1 A GLN 270 ? NE2 ? A GLN 230 NE2 
52  1 Y 1 A TRP 281 ? CG  ? A TRP 241 CG  
53  1 Y 1 A TRP 281 ? CD1 ? A TRP 241 CD1 
54  1 Y 1 A TRP 281 ? CD2 ? A TRP 241 CD2 
55  1 Y 1 A TRP 281 ? NE1 ? A TRP 241 NE1 
56  1 Y 1 A TRP 281 ? CE2 ? A TRP 241 CE2 
57  1 Y 1 A TRP 281 ? CE3 ? A TRP 241 CE3 
58  1 Y 1 A TRP 281 ? CZ2 ? A TRP 241 CZ2 
59  1 Y 1 A TRP 281 ? CZ3 ? A TRP 241 CZ3 
60  1 Y 1 A TRP 281 ? CH2 ? A TRP 241 CH2 
61  1 Y 1 A GLU 295 ? CG  ? A GLU 255 CG  
62  1 Y 1 A GLU 295 ? CD  ? A GLU 255 CD  
63  1 Y 1 A GLU 295 ? OE1 ? A GLU 255 OE1 
64  1 Y 1 A GLU 295 ? OE2 ? A GLU 255 OE2 
65  1 Y 1 A GLU 300 ? CG  ? A GLU 260 CG  
66  1 Y 1 A GLU 300 ? CD  ? A GLU 260 CD  
67  1 Y 1 A GLU 300 ? OE1 ? A GLU 260 OE1 
68  1 Y 1 A GLU 300 ? OE2 ? A GLU 260 OE2 
69  1 Y 1 A GLU 308 ? CG  ? A GLU 268 CG  
70  1 Y 1 A GLU 308 ? CD  ? A GLU 268 CD  
71  1 Y 1 A GLU 308 ? OE1 ? A GLU 268 OE1 
72  1 Y 1 A GLU 308 ? OE2 ? A GLU 268 OE2 
73  1 Y 1 A LYS 309 ? CG  ? A LYS 269 CG  
74  1 Y 1 A LYS 309 ? CD  ? A LYS 269 CD  
75  1 Y 1 A LYS 309 ? CE  ? A LYS 269 CE  
76  1 Y 1 A LYS 309 ? NZ  ? A LYS 269 NZ  
77  1 Y 1 A ILE 310 ? CG1 ? A ILE 270 CG1 
78  1 Y 1 A ILE 310 ? CG2 ? A ILE 270 CG2 
79  1 Y 1 A ILE 310 ? CD1 ? A ILE 270 CD1 
80  1 Y 1 A LYS 325 ? CG  ? A LYS 285 CG  
81  1 Y 1 A LYS 325 ? CD  ? A LYS 285 CD  
82  1 Y 1 A LYS 325 ? CE  ? A LYS 285 CE  
83  1 Y 1 A LYS 325 ? NZ  ? A LYS 285 NZ  
84  1 Y 1 A ASN 326 ? CG  ? A ASN 286 CG  
85  1 Y 1 A ASN 326 ? OD1 ? A ASN 286 OD1 
86  1 Y 1 A ASN 326 ? ND2 ? A ASN 286 ND2 
87  1 Y 1 A GLU 337 ? CG  ? A GLU 297 CG  
88  1 Y 1 A GLU 337 ? CD  ? A GLU 297 CD  
89  1 Y 1 A GLU 337 ? OE1 ? A GLU 297 OE1 
90  1 Y 1 A GLU 337 ? OE2 ? A GLU 297 OE2 
91  1 Y 1 A GLN 349 ? CG  ? A GLN 309 CG  
92  1 Y 1 A GLN 349 ? CD  ? A GLN 309 CD  
93  1 Y 1 A GLN 349 ? OE1 ? A GLN 309 OE1 
94  1 Y 1 A GLN 349 ? NE2 ? A GLN 309 NE2 
95  1 Y 1 A GLU 362 ? CG  ? A GLU 322 CG  
96  1 Y 1 A GLU 362 ? CD  ? A GLU 322 CD  
97  1 Y 1 A GLU 362 ? OE1 ? A GLU 322 OE1 
98  1 Y 1 A GLU 362 ? OE2 ? A GLU 322 OE2 
99  1 Y 1 A HIS 387 ? CG  ? A HIS 347 CG  
100 1 Y 1 A HIS 387 ? ND1 ? A HIS 347 ND1 
101 1 Y 1 A HIS 387 ? CD2 ? A HIS 347 CD2 
102 1 Y 1 A HIS 387 ? CE1 ? A HIS 347 CE1 
103 1 Y 1 A HIS 387 ? NE2 ? A HIS 347 NE2 
104 1 Y 1 A ASN 422 ? CG  ? A ASN 382 CG  
105 1 Y 1 A ASN 422 ? OD1 ? A ASN 382 OD1 
106 1 Y 1 A ASN 422 ? ND2 ? A ASN 382 ND2 
107 1 Y 1 A ARG 425 ? CG  ? A ARG 385 CG  
108 1 Y 1 A ARG 425 ? CD  ? A ARG 385 CD  
109 1 Y 1 A ARG 425 ? NE  ? A ARG 385 NE  
110 1 Y 1 A ARG 425 ? CZ  ? A ARG 385 CZ  
111 1 Y 1 A ARG 425 ? NH1 ? A ARG 385 NH1 
112 1 Y 1 A ARG 425 ? NH2 ? A ARG 385 NH2 
113 1 Y 1 A GLN 435 ? CG  ? A GLN 395 CG  
114 1 Y 1 A GLN 435 ? CD  ? A GLN 395 CD  
115 1 Y 1 A GLN 435 ? OE1 ? A GLN 395 OE1 
116 1 Y 1 A GLN 435 ? NE2 ? A GLN 395 NE2 
117 1 Y 1 A GLU 439 ? CG  ? A GLU 399 CG  
118 1 Y 1 A GLU 439 ? CD  ? A GLU 399 CD  
119 1 Y 1 A GLU 439 ? OE1 ? A GLU 399 OE1 
120 1 Y 1 A GLU 439 ? OE2 ? A GLU 399 OE2 
121 1 Y 1 B LYS 19  ? CG  ? B LYS 19  CG  
122 1 Y 1 B LYS 19  ? CD  ? B LYS 19  CD  
123 1 Y 1 B LYS 19  ? CE  ? B LYS 19  CE  
124 1 Y 1 B LYS 19  ? NZ  ? B LYS 19  NZ  
125 1 Y 1 B GLU 26  ? CG  ? B GLU 26  CG  
126 1 Y 1 B GLU 26  ? CD  ? B GLU 26  CD  
127 1 Y 1 B GLU 26  ? OE1 ? B GLU 26  OE1 
128 1 Y 1 B GLU 26  ? OE2 ? B GLU 26  OE2 
129 1 Y 1 B LYS 36  ? CG  ? B LYS 36  CG  
130 1 Y 1 B LYS 36  ? CD  ? B LYS 36  CD  
131 1 Y 1 B LYS 36  ? CE  ? B LYS 36  CE  
132 1 Y 1 B LYS 36  ? NZ  ? B LYS 36  NZ  
133 1 Y 1 B ARG 37  ? CG  ? B ARG 37  CG  
134 1 Y 1 B ARG 37  ? CD  ? B ARG 37  CD  
135 1 Y 1 B ARG 37  ? NE  ? B ARG 37  NE  
136 1 Y 1 B ARG 37  ? CZ  ? B ARG 37  CZ  
137 1 Y 1 B ARG 37  ? NH1 ? B ARG 37  NH1 
138 1 Y 1 B ARG 37  ? NH2 ? B ARG 37  NH2 
139 1 Y 1 B GLU 41  ? CG  ? B GLU 41  CG  
140 1 Y 1 B GLU 41  ? CD  ? B GLU 41  CD  
141 1 Y 1 B GLU 41  ? OE1 ? B GLU 41  OE1 
142 1 Y 1 B GLU 41  ? OE2 ? B GLU 41  OE2 
143 1 Y 1 B LYS 55  ? CG  ? B LYS 55  CG  
144 1 Y 1 B LYS 55  ? CD  ? B LYS 55  CD  
145 1 Y 1 B LYS 55  ? CE  ? B LYS 55  CE  
146 1 Y 1 B LYS 55  ? NZ  ? B LYS 55  NZ  
147 1 Y 1 B GLN 65  ? CG  ? B GLN 65  CG  
148 1 Y 1 B GLN 65  ? CD  ? B GLN 65  CD  
149 1 Y 1 B GLN 65  ? OE1 ? B GLN 65  OE1 
150 1 Y 1 B GLN 65  ? NE2 ? B GLN 65  NE2 
151 1 Y 1 B ARG 68  ? CG  ? B ARG 68  CG  
152 1 Y 1 B ARG 68  ? CD  ? B ARG 68  CD  
153 1 Y 1 B ARG 68  ? NE  ? B ARG 68  NE  
154 1 Y 1 B ARG 68  ? CZ  ? B ARG 68  CZ  
155 1 Y 1 B ARG 68  ? NH1 ? B ARG 68  NH1 
156 1 Y 1 B ARG 68  ? NH2 ? B ARG 68  NH2 
157 1 Y 1 B GLU 98  ? CG  ? B GLU 98  CG  
158 1 Y 1 B GLU 98  ? CD  ? B GLU 98  CD  
159 1 Y 1 B GLU 98  ? OE1 ? B GLU 98  OE1 
160 1 Y 1 B GLU 98  ? OE2 ? B GLU 98  OE2 
161 1 Y 1 C MET 17  ? CG  ? C MET 17  CG  
162 1 Y 1 C MET 17  ? SD  ? C MET 17  SD  
163 1 Y 1 C MET 17  ? CE  ? C MET 17  CE  
164 1 Y 1 C ARG 33  ? CG  ? C ARG 33  CG  
165 1 Y 1 C ARG 33  ? CD  ? C ARG 33  CD  
166 1 Y 1 C ARG 33  ? NE  ? C ARG 33  NE  
167 1 Y 1 C ARG 33  ? CZ  ? C ARG 33  CZ  
168 1 Y 1 C ARG 33  ? NH1 ? C ARG 33  NH1 
169 1 Y 1 C ARG 33  ? NH2 ? C ARG 33  NH2 
170 1 Y 1 C LYS 43  ? CG  ? C LYS 43  CG  
171 1 Y 1 C LYS 43  ? CD  ? C LYS 43  CD  
172 1 Y 1 C LYS 43  ? CE  ? C LYS 43  CE  
173 1 Y 1 C LYS 43  ? NZ  ? C LYS 43  NZ  
174 1 Y 1 C GLU 59  ? CG  ? C GLU 59  CG  
175 1 Y 1 C GLU 59  ? CD  ? C GLU 59  CD  
176 1 Y 1 C GLU 59  ? OE1 ? C GLU 59  OE1 
177 1 Y 1 C GLU 59  ? OE2 ? C GLU 59  OE2 
178 1 Y 1 C ARG 63  ? CG  ? C ARG 63  CG  
179 1 Y 1 C ARG 63  ? CD  ? C ARG 63  CD  
180 1 Y 1 C ARG 63  ? NE  ? C ARG 63  NE  
181 1 Y 1 C ARG 63  ? CZ  ? C ARG 63  CZ  
182 1 Y 1 C ARG 63  ? NH1 ? C ARG 63  NH1 
183 1 Y 1 C ARG 63  ? NH2 ? C ARG 63  NH2 
184 1 Y 1 C ASN 85  ? CG  ? C ASN 85  CG  
185 1 Y 1 C ASN 85  ? OD1 ? C ASN 85  OD1 
186 1 Y 1 C ASN 85  ? ND2 ? C ASN 85  ND2 
187 1 Y 1 C GLU 89  ? CG  ? C GLU 89  CG  
188 1 Y 1 C GLU 89  ? CD  ? C GLU 89  CD  
189 1 Y 1 C GLU 89  ? OE1 ? C GLU 89  OE1 
190 1 Y 1 C GLU 89  ? OE2 ? C GLU 89  OE2 
191 1 Y 1 C GLU 92  ? CG  ? C GLU 92  CG  
192 1 Y 1 C GLU 92  ? CD  ? C GLU 92  CD  
193 1 Y 1 C GLU 92  ? OE1 ? C GLU 92  OE1 
194 1 Y 1 C GLU 92  ? OE2 ? C GLU 92  OE2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9D8P 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9D8P 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9D8P 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9D8P 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003 ? 4177 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.474 ? 5689 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 4.326 ? 575  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.041 ? 642  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.003 ? 726  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9D8P 
_struct.title                        'Focused map of Cryo-EM structure of Ubiquitin C-degron bound to KLHDC10-EloB/C' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9D8P 
_struct_keywords.text            'KLHDC10, ubiquitin, E3, Cullin-RING, C-Degron, LIGASE' 
_struct_keywords.pdbx_keywords   LIGASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP KLD10_HUMAN Q6PID8 ? 1 
;QLNRFVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGP
DNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR
GKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTS
WTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATM
PEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQGLIER
LK
;
41 
2 UNP ELOB_HUMAN  Q15370 ? 2 
;MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR
ADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
;
1  
3 UNP ELOC_HUMAN  Q15369 ? 3 
;MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYK
VRYTNSSTEIPEFPIAPEIALELLMAANFLDC
;
1  
4 UNP UBC_HUMAN   P0CG48 ? 4 MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 1  
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9D8P A 1 ? 402 ? Q6PID8 41 ? 442 ? 41 442 
2 2 9D8P B 1 ? 118 ? Q15370 1  ? 118 ? 1  118 
3 3 9D8P C 1 ? 112 ? Q15369 1  ? 112 ? 1  112 
4 4 9D8P D 1 ? 76  ? P0CG48 1  ? 76  ? 1  76  
# 
_struct_ref_seq_dif.align_id                     4 
_struct_ref_seq_dif.pdbx_pdb_id_code             9D8P 
_struct_ref_seq_dif.mon_id                       CYS 
_struct_ref_seq_dif.pdbx_pdb_strand_id           D 
_struct_ref_seq_dif.seq_num                      48 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P0CG48 
_struct_ref_seq_dif.db_mon_id                    LYS 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          48 
_struct_ref_seq_dif.details                      'engineered mutation' 
_struct_ref_seq_dif.pdbx_auth_seq_num            48 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 78  ? ASN A 82  ? GLY A 118 ASN A 122 5 ? 5  
HELX_P HELX_P2  AA2 SER A 364 ? PHE A 377 ? SER A 404 PHE A 417 1 ? 14 
HELX_P HELX_P3  AA3 PRO A 378 ? LEU A 383 ? PRO A 418 LEU A 423 5 ? 6  
HELX_P HELX_P4  AA4 SER A 384 ? GLY A 392 ? SER A 424 GLY A 432 1 ? 9  
HELX_P HELX_P5  AA5 THR A 394 ? LYS A 402 ? THR A 434 LYS A 442 1 ? 9  
HELX_P HELX_P6  AA6 THR B 23  ? LYS B 36  ? THR B 23  LYS B 36  1 ? 14 
HELX_P HELX_P7  AA7 PRO B 38  ? GLN B 42  ? PRO B 38  GLN B 42  5 ? 5  
HELX_P HELX_P8  AA8 ARG C 33  ? LEU C 37  ? ARG C 33  LEU C 37  1 ? 5  
HELX_P HELX_P9  AA9 SER C 39  ? LEU C 46  ? SER C 39  LEU C 46  1 ? 8  
HELX_P HELX_P10 AB1 PRO C 66  ? THR C 84  ? PRO C 66  THR C 84  1 ? 19 
HELX_P HELX_P11 AB2 ILE C 99  ? ASP C 111 ? ILE C 99  ASP C 111 1 ? 13 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            57 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            328 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             97 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             368 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.031 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       57 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      328 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        97 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       368 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 TYR 85  A . ? TYR 125 A PRO 86  A ? PRO 126 A 1 1.88  
2 ILE 134 A . ? ILE 174 A PRO 135 A ? PRO 175 A 1 -2.42 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 5 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 2 ? 
AA8 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? parallel      
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? parallel      
AA8 3 4 ? anti-parallel 
AA8 4 5 ? parallel      
AA8 5 6 ? anti-parallel 
AA8 6 7 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 6   ? LEU A 8   ? VAL A 46  LEU A 48  
AA1 2 LEU A 355 ? TRP A 359 ? LEU A 395 TRP A 399 
AA1 3 CYS A 336 ? HIS A 340 ? CYS A 376 HIS A 380 
AA1 4 CYS A 328 ? VAL A 331 ? CYS A 368 VAL A 371 
AA2 1 ARG A 56  ? ALA A 59  ? ARG A 96  ALA A 99  
AA2 2 ASN A 63  ? PHE A 67  ? ASN A 103 PHE A 107 
AA2 3 LEU A 91  ? HIS A 95  ? LEU A 131 HIS A 135 
AA2 4 VAL A 100 ? GLN A 103 ? VAL A 140 GLN A 143 
AA3 1 SER A 118 ? HIS A 122 ? SER A 158 HIS A 162 
AA3 2 ASN A 125 ? PHE A 129 ? ASN A 165 PHE A 169 
AA3 3 VAL A 144 ? ASN A 148 ? VAL A 184 ASN A 188 
AA3 4 ARG A 153 ? LEU A 156 ? ARG A 193 LEU A 196 
AA4 1 ARG A 160 ? GLY A 161 ? ARG A 200 GLY A 201 
AA4 2 GLU A 203 ? THR A 205 ? GLU A 243 THR A 245 
AA4 3 LEU A 194 ? ASP A 198 ? LEU A 234 ASP A 238 
AA4 4 SER A 178 ? PHE A 182 ? SER A 218 PHE A 222 
AA4 5 ALA A 171 ? ILE A 175 ? ALA A 211 ILE A 215 
AA5 1 GLU A 224 ? HIS A 227 ? GLU A 264 HIS A 267 
AA5 2 ARG A 231 ? LEU A 235 ? ARG A 271 LEU A 275 
AA5 3 LYS A 248 ? ASN A 253 ? LYS A 288 ASN A 293 
AA5 4 ALA A 258 ? ALA A 263 ? ALA A 298 ALA A 303 
AA6 1 SER A 280 ? GLN A 283 ? SER A 320 GLN A 323 
AA6 2 ASP A 287 ? CYS A 291 ? ASP A 327 CYS A 331 
AA6 3 ILE A 303 ? ASN A 307 ? ILE A 343 ASN A 347 
AA6 4 TRP A 313 ? LYS A 315 ? TRP A 353 LYS A 355 
AA7 1 VAL A 343 ? ASN A 345 ? VAL A 383 ASN A 385 
AA7 2 LYS A 350 ? ARG A 351 ? LYS A 390 ARG A 391 
AA8 1 ARG B 43  ? TYR B 45  ? ARG B 43  TYR B 45  
AA8 2 ALA B 73  ? ALA B 78  ? ALA B 73  ALA B 78  
AA8 3 VAL B 3   ? ARG B 9   ? VAL B 3   ARG B 9   
AA8 4 THR B 12  ? ALA B 18  ? THR B 12  ALA B 18  
AA8 5 GLU C 28  ? LYS C 32  ? GLU C 28  LYS C 32  
AA8 6 TYR C 18  ? ILE C 22  ? TYR C 18  ILE C 22  
AA8 7 GLU C 59  ? ASN C 61  ? GLU C 59  ASN C 61  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 8   ? N LEU A 48  O LEU A 355 ? O LEU A 395 
AA1 2 3 O PHE A 356 ? O PHE A 396 N ILE A 339 ? N ILE A 379 
AA1 3 4 O HIS A 340 ? O HIS A 380 N CYS A 328 ? N CYS A 368 
AA2 1 2 N ARG A 56  ? N ARG A 96  O PHE A 67  ? O PHE A 107 
AA2 2 3 N VAL A 66  ? N VAL A 106 O TRP A 92  ? O TRP A 132 
AA2 3 4 N ARG A 93  ? N ARG A 133 O HIS A 102 ? O HIS A 142 
AA3 1 2 N SER A 118 ? N SER A 158 O PHE A 129 ? O PHE A 169 
AA3 2 3 N VAL A 128 ? N VAL A 168 O HIS A 145 ? O HIS A 185 
AA3 3 4 N VAL A 146 ? N VAL A 186 O ALA A 155 ? O ALA A 195 
AA4 1 2 N ARG A 160 ? N ARG A 200 O TRP A 204 ? O TRP A 244 
AA4 2 3 O THR A 205 ? O THR A 245 N LYS A 196 ? N LYS A 236 
AA4 3 4 O HIS A 195 ? O HIS A 235 N VAL A 181 ? N VAL A 221 
AA4 4 5 O TYR A 180 ? O TYR A 220 N ALA A 173 ? N ALA A 213 
AA5 1 2 N GLU A 224 ? N GLU A 264 O LEU A 235 ? O LEU A 275 
AA5 2 3 N ILE A 232 ? N ILE A 272 O TYR A 252 ? O TYR A 292 
AA5 3 4 N ILE A 249 ? N ILE A 289 O ILE A 262 ? O ILE A 302 
AA6 1 2 N VAL A 282 ? N VAL A 322 O PHE A 289 ? O PHE A 329 
AA6 2 3 N ILE A 290 ? N ILE A 330 O TRP A 304 ? O TRP A 344 
AA6 3 4 N LYS A 305 ? N LYS A 345 O VAL A 314 ? O VAL A 354 
AA7 1 2 N VAL A 344 ? N VAL A 384 O LYS A 350 ? O LYS A 390 
AA8 1 2 N TYR B 45  ? N TYR B 45  O GLY B 76  ? O GLY B 76  
AA8 2 3 O LEU B 77  ? O LEU B 77  N ARG B 8   ? N ARG B 8   
AA8 3 4 N LEU B 5   ? N LEU B 5   O THR B 16  ? O THR B 16  
AA8 4 5 N THR B 13  ? N THR B 13  O ILE C 30  ? O ILE C 30  
AA8 5 6 O PHE C 29  ? O PHE C 29  N LEU C 21  ? N LEU C 21  
AA8 6 7 N LYS C 20  ? N LYS C 20  O VAL C 60  ? O VAL C 60  
# 
_pdbx_entry_details.entry_id                   9D8P 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 100 ? ? -127.10 -169.86 
2  1 PRO A 126 ? ? -91.08  32.71   
3  1 SER A 198 ? ? -98.96  37.54   
4  1 LYS A 309 ? ? -140.17 16.26   
5  1 LYS A 325 ? ? 53.52   -128.86 
6  1 ASN A 326 ? ? -96.28  56.00   
7  1 PRO A 357 ? ? -80.47  47.05   
8  1 HIS B 10  ? ? 57.20   -129.54 
9  1 ALA B 71  ? ? -160.22 65.68   
10 1 ASP C 111 ? ? 57.98   70.66   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9D8P 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9D8P 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.2 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               234648 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               'MULTIPLE SOURCES' 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Trapped ARIH1-diUB-CRL2-KLHDC10 complex' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3, 4' 
# 
_em_imaging.entry_id                        9D8P 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             600 
_em_imaging.nominal_defocus_max             2250 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           130000 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9D8P 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9D8P 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9D8P 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A ARG 51  ? A ARG 11  
2   1 Y 1 A PRO 52  ? A PRO 12  
3   1 Y 1 A HIS 53  ? A HIS 13  
4   1 Y 1 A LEU 54  ? A LEU 14  
5   1 Y 1 A PRO 55  ? A PRO 15  
6   1 Y 1 A GLY 56  ? A GLY 16  
7   1 Y 1 A LYS 57  ? A LYS 17  
8   1 Y 1 A LYS 58  ? A LYS 18  
9   1 Y 1 A LYS 59  ? A LYS 19  
10  1 Y 1 A ILE 60  ? A ILE 20  
11  1 Y 1 A ARG 61  ? A ARG 21  
12  1 Y 1 A TRP 62  ? A TRP 22  
13  1 Y 1 A ASP 63  ? A ASP 23  
14  1 Y 1 A PRO 64  ? A PRO 24  
15  1 Y 1 A VAL 65  ? A VAL 25  
16  1 Y 1 A ARG 66  ? A ARG 26  
17  1 Y 1 A ARG 67  ? A ARG 27  
18  1 Y 1 A ARG 68  ? A ARG 28  
19  1 Y 1 A PHE 69  ? A PHE 29  
20  1 Y 1 A ILE 70  ? A ILE 30  
21  1 Y 1 A GLN 71  ? A GLN 31  
22  1 Y 1 A SER 72  ? A SER 32  
23  1 Y 1 A CYS 73  ? A CYS 33  
24  1 Y 1 A PRO 74  ? A PRO 34  
25  1 Y 1 A ILE 75  ? A ILE 35  
26  1 Y 1 A ILE 76  ? A ILE 36  
27  1 Y 1 A ARG 77  ? A ARG 37  
28  1 Y 1 A ILE 78  ? A ILE 38  
29  1 Y 1 A PRO 79  ? A PRO 39  
30  1 Y 1 A ASN 80  ? A ASN 40  
31  1 Y 1 A ARG 81  ? A ARG 41  
32  1 Y 1 A PHE 82  ? A PHE 42  
33  1 Y 1 A LEU 83  ? A LEU 43  
34  1 Y 1 A ARG 84  ? A ARG 44  
35  1 Y 1 A GLY 85  ? A GLY 45  
36  1 Y 1 A HIS 86  ? A HIS 46  
37  1 Y 1 A ASN 250 ? A ASN 210 
38  1 Y 1 A ASN 251 ? A ASN 211 
39  1 Y 1 A LEU 252 ? A LEU 212 
40  1 Y 1 A SER 253 ? A SER 213 
41  1 Y 1 A CYS 254 ? A CYS 214 
42  1 Y 1 A ASP 255 ? A ASP 215 
43  1 Y 1 B MET 1   ? B MET 1   
44  1 Y 1 B LYS 46  ? B LYS 46  
45  1 Y 1 B ASP 47  ? B ASP 47  
46  1 Y 1 B ASP 48  ? B ASP 48  
47  1 Y 1 B GLN 49  ? B GLN 49  
48  1 Y 1 B LEU 50  ? B LEU 50  
49  1 Y 1 B LEU 51  ? B LEU 51  
50  1 Y 1 B ASP 52  ? B ASP 52  
51  1 Y 1 B ARG 80  ? B ARG 80  
52  1 Y 1 B ALA 81  ? B ALA 81  
53  1 Y 1 B ASP 82  ? B ASP 82  
54  1 Y 1 B ASP 83  ? B ASP 83  
55  1 Y 1 B THR 84  ? B THR 84  
56  1 Y 1 B PHE 85  ? B PHE 85  
57  1 Y 1 B MET 103 ? B MET 103 
58  1 Y 1 B LYS 104 ? B LYS 104 
59  1 Y 1 B PRO 105 ? B PRO 105 
60  1 Y 1 B GLN 106 ? B GLN 106 
61  1 Y 1 B ASP 107 ? B ASP 107 
62  1 Y 1 B SER 108 ? B SER 108 
63  1 Y 1 B GLY 109 ? B GLY 109 
64  1 Y 1 B SER 110 ? B SER 110 
65  1 Y 1 B SER 111 ? B SER 111 
66  1 Y 1 B ALA 112 ? B ALA 112 
67  1 Y 1 B ASN 113 ? B ASN 113 
68  1 Y 1 B GLU 114 ? B GLU 114 
69  1 Y 1 B GLN 115 ? B GLN 115 
70  1 Y 1 B ALA 116 ? B ALA 116 
71  1 Y 1 B VAL 117 ? B VAL 117 
72  1 Y 1 B GLN 118 ? B GLN 118 
73  1 Y 1 C MET 1   ? C MET 1   
74  1 Y 1 C ASP 2   ? C ASP 2   
75  1 Y 1 C GLY 3   ? C GLY 3   
76  1 Y 1 C GLU 4   ? C GLU 4   
77  1 Y 1 C GLU 5   ? C GLU 5   
78  1 Y 1 C LYS 6   ? C LYS 6   
79  1 Y 1 C THR 7   ? C THR 7   
80  1 Y 1 C TYR 8   ? C TYR 8   
81  1 Y 1 C GLY 9   ? C GLY 9   
82  1 Y 1 C GLY 10  ? C GLY 10  
83  1 Y 1 C CYS 11  ? C CYS 11  
84  1 Y 1 C GLU 12  ? C GLU 12  
85  1 Y 1 C GLY 13  ? C GLY 13  
86  1 Y 1 C PRO 14  ? C PRO 14  
87  1 Y 1 C ASP 15  ? C ASP 15  
88  1 Y 1 C ALA 16  ? C ALA 16  
89  1 Y 1 C SER 47  ? C SER 47  
90  1 Y 1 C GLY 48  ? C GLY 48  
91  1 Y 1 C PRO 49  ? C PRO 49  
92  1 Y 1 C GLY 50  ? C GLY 50  
93  1 Y 1 C GLN 51  ? C GLN 51  
94  1 Y 1 C PHE 52  ? C PHE 52  
95  1 Y 1 C ALA 53  ? C ALA 53  
96  1 Y 1 C GLU 54  ? C GLU 54  
97  1 Y 1 C ASN 55  ? C ASN 55  
98  1 Y 1 C GLU 56  ? C GLU 56  
99  1 Y 1 C THR 57  ? C THR 57  
100 1 Y 1 D MET 1   ? D MET 1   
101 1 Y 1 D GLN 2   ? D GLN 2   
102 1 Y 1 D ILE 3   ? D ILE 3   
103 1 Y 1 D PHE 4   ? D PHE 4   
104 1 Y 1 D VAL 5   ? D VAL 5   
105 1 Y 1 D LYS 6   ? D LYS 6   
106 1 Y 1 D THR 7   ? D THR 7   
107 1 Y 1 D LEU 8   ? D LEU 8   
108 1 Y 1 D THR 9   ? D THR 9   
109 1 Y 1 D GLY 10  ? D GLY 10  
110 1 Y 1 D LYS 11  ? D LYS 11  
111 1 Y 1 D THR 12  ? D THR 12  
112 1 Y 1 D ILE 13  ? D ILE 13  
113 1 Y 1 D THR 14  ? D THR 14  
114 1 Y 1 D LEU 15  ? D LEU 15  
115 1 Y 1 D GLU 16  ? D GLU 16  
116 1 Y 1 D VAL 17  ? D VAL 17  
117 1 Y 1 D GLU 18  ? D GLU 18  
118 1 Y 1 D PRO 19  ? D PRO 19  
119 1 Y 1 D SER 20  ? D SER 20  
120 1 Y 1 D ASP 21  ? D ASP 21  
121 1 Y 1 D THR 22  ? D THR 22  
122 1 Y 1 D ILE 23  ? D ILE 23  
123 1 Y 1 D GLU 24  ? D GLU 24  
124 1 Y 1 D ASN 25  ? D ASN 25  
125 1 Y 1 D VAL 26  ? D VAL 26  
126 1 Y 1 D LYS 27  ? D LYS 27  
127 1 Y 1 D ALA 28  ? D ALA 28  
128 1 Y 1 D LYS 29  ? D LYS 29  
129 1 Y 1 D ILE 30  ? D ILE 30  
130 1 Y 1 D GLN 31  ? D GLN 31  
131 1 Y 1 D ASP 32  ? D ASP 32  
132 1 Y 1 D LYS 33  ? D LYS 33  
133 1 Y 1 D GLU 34  ? D GLU 34  
134 1 Y 1 D GLY 35  ? D GLY 35  
135 1 Y 1 D ILE 36  ? D ILE 36  
136 1 Y 1 D PRO 37  ? D PRO 37  
137 1 Y 1 D PRO 38  ? D PRO 38  
138 1 Y 1 D ASP 39  ? D ASP 39  
139 1 Y 1 D GLN 40  ? D GLN 40  
140 1 Y 1 D GLN 41  ? D GLN 41  
141 1 Y 1 D ARG 42  ? D ARG 42  
142 1 Y 1 D LEU 43  ? D LEU 43  
143 1 Y 1 D ILE 44  ? D ILE 44  
144 1 Y 1 D PHE 45  ? D PHE 45  
145 1 Y 1 D ALA 46  ? D ALA 46  
146 1 Y 1 D GLY 47  ? D GLY 47  
147 1 Y 1 D CYS 48  ? D CYS 48  
148 1 Y 1 D GLN 49  ? D GLN 49  
149 1 Y 1 D LEU 50  ? D LEU 50  
150 1 Y 1 D GLU 51  ? D GLU 51  
151 1 Y 1 D ASP 52  ? D ASP 52  
152 1 Y 1 D GLY 53  ? D GLY 53  
153 1 Y 1 D ARG 54  ? D ARG 54  
154 1 Y 1 D THR 55  ? D THR 55  
155 1 Y 1 D LEU 56  ? D LEU 56  
156 1 Y 1 D SER 57  ? D SER 57  
157 1 Y 1 D ASP 58  ? D ASP 58  
158 1 Y 1 D TYR 59  ? D TYR 59  
159 1 Y 1 D ASN 60  ? D ASN 60  
160 1 Y 1 D ILE 61  ? D ILE 61  
161 1 Y 1 D GLN 62  ? D GLN 62  
162 1 Y 1 D LYS 63  ? D LYS 63  
163 1 Y 1 D GLU 64  ? D GLU 64  
164 1 Y 1 D SER 65  ? D SER 65  
165 1 Y 1 D THR 66  ? D THR 66  
166 1 Y 1 D LEU 67  ? D LEU 67  
167 1 Y 1 D HIS 68  ? D HIS 68  
168 1 Y 1 D LEU 69  ? D LEU 69  
169 1 Y 1 D VAL 70  ? D VAL 70  
170 1 Y 1 D LEU 71  ? D LEU 71  
171 1 Y 1 D ARG 72  ? D ARG 72  
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-08-19 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9D8P 
_em_admin.last_update        2025-02-05 
_em_admin.map_release_date   2024-11-20 
_em_admin.title              'Focused map of Cryo-EM structure of Ubiquitin C-degron bound to KLHDC10-EloB/C' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         40 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     13395 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ?      ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ?      ? 
MASKING                    ? 3  ? ? ? ?      ? 
'CTF CORRECTION'           ? 4  1 ? ? ?      ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ?      ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ?      ? 
'MODEL FITTING'            ? 7  ? 1 ? Coot   ? 
OTHER                      ? 8  ? ? ? ?      ? 
'MODEL REFINEMENT'         ? 9  ? 1 ? PHENIX ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ?      ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ?      ? 
CLASSIFICATION             ? 12 1 ? ? ?      ? 
RECONSTRUCTION             ? 13 1 ? ? ?      ? 
# 
_em_specimen.concentration           0.8 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Cancer Institute (NIH/NCI)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           5R01CA247365 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9D8P 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . GLN A 1 1   ? 203.691 237.404 192.100 1.00 148.88 ? 41  GLN A N   1 
ATOM 2    C CA  . GLN A 1 1   ? 203.762 235.950 192.173 1.00 142.87 ? 41  GLN A CA  1 
ATOM 3    C C   . GLN A 1 1   ? 205.200 235.457 192.041 1.00 139.04 ? 41  GLN A C   1 
ATOM 4    O O   . GLN A 1 1   ? 205.446 234.339 191.591 1.00 137.90 ? 41  GLN A O   1 
ATOM 5    C CB  . GLN A 1 1   ? 202.884 235.317 191.091 1.00 145.13 ? 41  GLN A CB  1 
ATOM 6    C CG  . GLN A 1 1   ? 203.312 235.639 189.669 1.00 150.88 ? 41  GLN A CG  1 
ATOM 7    C CD  . GLN A 1 1   ? 202.387 236.631 188.996 1.00 158.26 ? 41  GLN A CD  1 
ATOM 8    O OE1 . GLN A 1 1   ? 202.218 237.757 189.464 1.00 158.25 ? 41  GLN A OE1 1 
ATOM 9    N NE2 . GLN A 1 1   ? 201.779 236.217 187.890 1.00 161.89 ? 41  GLN A NE2 1 
ATOM 10   N N   . LEU A 1 2   ? 206.152 236.298 192.444 1.00 135.36 ? 42  LEU A N   1 
ATOM 11   C CA  . LEU A 1 2   ? 207.564 235.947 192.398 1.00 130.16 ? 42  LEU A CA  1 
ATOM 12   C C   . LEU A 1 2   ? 208.133 235.519 193.740 1.00 124.37 ? 42  LEU A C   1 
ATOM 13   O O   . LEU A 1 2   ? 209.121 234.784 193.767 1.00 121.20 ? 42  LEU A O   1 
ATOM 14   C CB  . LEU A 1 2   ? 208.391 237.123 191.865 1.00 131.82 ? 42  LEU A CB  1 
ATOM 15   C CG  . LEU A 1 2   ? 208.801 237.051 190.393 1.00 131.17 ? 42  LEU A CG  1 
ATOM 16   C CD1 . LEU A 1 2   ? 210.023 237.917 190.137 1.00 126.32 ? 42  LEU A CD1 1 
ATOM 17   C CD2 . LEU A 1 2   ? 209.064 235.614 189.971 1.00 123.92 ? 42  LEU A CD2 1 
ATOM 18   N N   . ASN A 1 3   ? 207.536 235.953 194.852 1.00 124.69 ? 43  ASN A N   1 
ATOM 19   C CA  . ASN A 1 3   ? 208.008 235.588 196.182 1.00 118.38 ? 43  ASN A CA  1 
ATOM 20   C C   . ASN A 1 3   ? 207.302 234.357 196.737 1.00 121.77 ? 43  ASN A C   1 
ATOM 21   O O   . ASN A 1 3   ? 207.175 234.216 197.961 1.00 120.01 ? 43  ASN A O   1 
ATOM 22   C CB  . ASN A 1 3   ? 207.855 236.770 197.140 1.00 116.18 ? 43  ASN A CB  1 
ATOM 23   C CG  . ASN A 1 3   ? 206.408 237.142 197.380 1.00 122.60 ? 43  ASN A CG  1 
ATOM 24   O OD1 . ASN A 1 3   ? 205.528 236.803 196.590 1.00 125.88 ? 43  ASN A OD1 1 
ATOM 25   N ND2 . ASN A 1 3   ? 206.155 237.846 198.476 1.00 120.89 ? 43  ASN A ND2 1 
ATOM 26   N N   . ARG A 1 4   ? 206.840 233.464 195.870 1.00 123.69 ? 44  ARG A N   1 
ATOM 27   C CA  . ARG A 1 4   ? 206.185 232.228 196.265 1.00 114.32 ? 44  ARG A CA  1 
ATOM 28   C C   . ARG A 1 4   ? 207.113 231.045 196.018 1.00 107.17 ? 44  ARG A C   1 
ATOM 29   O O   . ARG A 1 4   ? 208.142 231.157 195.349 1.00 102.96 ? 44  ARG A O   1 
ATOM 30   C CB  . ARG A 1 4   ? 204.869 232.044 195.503 1.00 119.03 ? 44  ARG A CB  1 
ATOM 31   C CG  . ARG A 1 4   ? 205.014 232.163 193.997 1.00 124.38 ? 44  ARG A CG  1 
ATOM 32   C CD  . ARG A 1 4   ? 203.663 232.163 193.304 1.00 137.56 ? 44  ARG A CD  1 
ATOM 33   N NE  . ARG A 1 4   ? 202.949 230.908 193.503 1.00 141.07 ? 44  ARG A NE  1 
ATOM 34   C CZ  . ARG A 1 4   ? 201.628 230.791 193.509 1.00 144.98 ? 44  ARG A CZ  1 
ATOM 35   N NH1 . ARG A 1 4   ? 200.841 231.837 193.321 1.00 142.53 ? 44  ARG A NH1 1 
ATOM 36   N NH2 . ARG A 1 4   ? 201.084 229.593 193.706 1.00 146.27 ? 44  ARG A NH2 1 
ATOM 37   N N   . PHE A 1 5   ? 206.733 229.898 196.573 1.00 107.12 ? 45  PHE A N   1 
ATOM 38   C CA  . PHE A 1 5   ? 207.518 228.682 196.414 1.00 104.54 ? 45  PHE A CA  1 
ATOM 39   C C   . PHE A 1 5   ? 207.187 228.020 195.084 1.00 102.98 ? 45  PHE A C   1 
ATOM 40   O O   . PHE A 1 5   ? 206.015 227.793 194.768 1.00 105.43 ? 45  PHE A O   1 
ATOM 41   C CB  . PHE A 1 5   ? 207.246 227.716 197.565 1.00 99.36  ? 45  PHE A CB  1 
ATOM 42   C CG  . PHE A 1 5   ? 207.842 228.147 198.871 1.00 100.67 ? 45  PHE A CG  1 
ATOM 43   C CD1 . PHE A 1 5   ? 209.166 227.877 199.165 1.00 100.43 ? 45  PHE A CD1 1 
ATOM 44   C CD2 . PHE A 1 5   ? 207.077 228.821 199.806 1.00 102.39 ? 45  PHE A CD2 1 
ATOM 45   C CE1 . PHE A 1 5   ? 209.716 228.272 200.366 1.00 103.03 ? 45  PHE A CE1 1 
ATOM 46   C CE2 . PHE A 1 5   ? 207.623 229.218 201.010 1.00 99.88  ? 45  PHE A CE2 1 
ATOM 47   C CZ  . PHE A 1 5   ? 208.944 228.943 201.289 1.00 98.98  ? 45  PHE A CZ  1 
ATOM 48   N N   . VAL A 1 6   ? 208.220 227.711 194.304 1.00 94.91  ? 46  VAL A N   1 
ATOM 49   C CA  . VAL A 1 6   ? 208.071 227.040 193.019 1.00 88.51  ? 46  VAL A CA  1 
ATOM 50   C C   . VAL A 1 6   ? 208.882 225.754 193.059 1.00 90.47  ? 46  VAL A C   1 
ATOM 51   O O   . VAL A 1 6   ? 210.068 225.777 193.403 1.00 92.11  ? 46  VAL A O   1 
ATOM 52   C CB  . VAL A 1 6   ? 208.524 227.933 191.851 1.00 90.51  ? 46  VAL A CB  1 
ATOM 53   C CG1 . VAL A 1 6   ? 207.968 227.408 190.540 1.00 96.18  ? 46  VAL A CG1 1 
ATOM 54   C CG2 . VAL A 1 6   ? 208.089 229.369 192.078 1.00 96.42  ? 46  VAL A CG2 1 
ATOM 55   N N   . GLN A 1 7   ? 208.247 224.640 192.704 1.00 92.66  ? 47  GLN A N   1 
ATOM 56   C CA  . GLN A 1 7   ? 208.904 223.340 192.731 1.00 90.75  ? 47  GLN A CA  1 
ATOM 57   C C   . GLN A 1 7   ? 209.638 223.098 191.420 1.00 90.90  ? 47  GLN A C   1 
ATOM 58   O O   . GLN A 1 7   ? 209.056 223.233 190.339 1.00 92.60  ? 47  GLN A O   1 
ATOM 59   C CB  . GLN A 1 7   ? 207.891 222.223 192.979 1.00 87.77  ? 47  GLN A CB  1 
ATOM 60   C CG  . GLN A 1 7   ? 208.527 220.852 193.143 1.00 90.78  ? 47  GLN A CG  1 
ATOM 61   C CD  . GLN A 1 7   ? 207.504 219.739 193.233 1.00 96.08  ? 47  GLN A CD  1 
ATOM 62   O OE1 . GLN A 1 7   ? 206.363 219.893 192.802 1.00 101.34 ? 47  GLN A OE1 1 
ATOM 63   N NE2 . GLN A 1 7   ? 207.911 218.606 193.793 1.00 93.43  ? 47  GLN A NE2 1 
ATOM 64   N N   . LEU A 1 8   ? 210.911 222.736 191.520 1.00 87.11  ? 48  LEU A N   1 
ATOM 65   C CA  . LEU A 1 8   ? 211.741 222.451 190.362 1.00 86.27  ? 48  LEU A CA  1 
ATOM 66   C C   . LEU A 1 8   ? 211.828 220.946 190.130 1.00 93.98  ? 48  LEU A C   1 
ATOM 67   O O   . LEU A 1 8   ? 211.484 220.134 190.991 1.00 99.79  ? 48  LEU A O   1 
ATOM 68   C CB  . LEU A 1 8   ? 213.138 223.048 190.544 1.00 83.64  ? 48  LEU A CB  1 
ATOM 69   C CG  . LEU A 1 8   ? 213.180 224.501 191.018 1.00 84.73  ? 48  LEU A CG  1 
ATOM 70   C CD1 . LEU A 1 8   ? 214.613 224.986 191.134 1.00 83.09  ? 48  LEU A CD1 1 
ATOM 71   C CD2 . LEU A 1 8   ? 212.386 225.394 190.082 1.00 85.82  ? 48  LEU A CD2 1 
ATOM 72   N N   . SER A 1 9   ? 212.298 220.580 188.942 1.00 93.53  ? 49  SER A N   1 
ATOM 73   C CA  . SER A 1 9   ? 212.428 219.181 188.560 1.00 96.99  ? 49  SER A CA  1 
ATOM 74   C C   . SER A 1 9   ? 213.520 219.070 187.503 1.00 100.44 ? 49  SER A C   1 
ATOM 75   O O   . SER A 1 9   ? 214.264 220.022 187.251 1.00 101.43 ? 49  SER A O   1 
ATOM 76   C CB  . SER A 1 9   ? 211.085 218.628 188.065 1.00 99.79  ? 49  SER A CB  1 
ATOM 77   O OG  . SER A 1 9   ? 210.216 218.353 189.148 1.00 109.17 ? 49  SER A OG  1 
ATOM 78   N N   . GLY A 1 10  ? 213.614 217.900 186.880 1.00 100.81 ? 50  GLY A N   1 
ATOM 79   C CA  . GLY A 1 10  ? 214.595 217.671 185.836 1.00 98.97  ? 50  GLY A CA  1 
ATOM 80   C C   . GLY A 1 10  ? 215.816 216.916 186.318 1.00 102.87 ? 50  GLY A C   1 
ATOM 81   O O   . GLY A 1 10  ? 216.709 216.599 185.533 1.00 103.93 ? 50  GLY A O   1 
ATOM 82   N N   . ARG A 1 47  ? 219.130 212.711 186.554 1.00 84.99  ? 87  ARG A N   1 
ATOM 83   C CA  . ARG A 1 47  ? 218.210 212.066 187.483 1.00 89.75  ? 87  ARG A CA  1 
ATOM 84   C C   . ARG A 1 47  ? 218.276 212.721 188.858 1.00 89.63  ? 87  ARG A C   1 
ATOM 85   O O   . ARG A 1 47  ? 219.352 212.821 189.445 1.00 87.59  ? 87  ARG A O   1 
ATOM 86   C CB  . ARG A 1 47  ? 218.524 210.575 187.596 1.00 92.47  ? 87  ARG A CB  1 
ATOM 87   C CG  . ARG A 1 47  ? 217.680 209.843 188.623 1.00 95.44  ? 87  ARG A CG  1 
ATOM 88   C CD  . ARG A 1 47  ? 216.306 209.523 188.065 1.00 100.74 ? 87  ARG A CD  1 
ATOM 89   N NE  . ARG A 1 47  ? 216.367 209.157 186.656 1.00 111.54 ? 87  ARG A NE  1 
ATOM 90   C CZ  . ARG A 1 47  ? 216.558 207.923 186.211 1.00 117.94 ? 87  ARG A CZ  1 
ATOM 91   N NH1 . ARG A 1 47  ? 216.708 206.904 187.041 1.00 117.97 ? 87  ARG A NH1 1 
ATOM 92   N NH2 . ARG A 1 47  ? 216.599 207.705 184.899 1.00 116.46 ? 87  ARG A NH2 1 
ATOM 93   N N   . PRO A 1 48  ? 217.129 213.171 189.364 1.00 86.20  ? 88  PRO A N   1 
ATOM 94   C CA  . PRO A 1 48  ? 217.117 213.820 190.670 1.00 78.71  ? 88  PRO A CA  1 
ATOM 95   C C   . PRO A 1 48  ? 217.545 212.852 191.752 1.00 79.83  ? 88  PRO A C   1 
ATOM 96   O O   . PRO A 1 48  ? 217.259 211.642 191.678 1.00 83.10  ? 88  PRO A O   1 
ATOM 97   C CB  . PRO A 1 48  ? 215.652 214.247 190.838 1.00 76.04  ? 88  PRO A CB  1 
ATOM 98   C CG  . PRO A 1 48  ? 214.888 213.347 189.941 1.00 82.38  ? 88  PRO A CG  1 
ATOM 99   C CD  . PRO A 1 48  ? 215.784 213.079 188.775 1.00 87.22  ? 88  PRO A CD  1 
ATOM 100  N N   . PRO A 1 49  ? 218.235 213.337 192.780 1.00 80.57  ? 89  PRO A N   1 
ATOM 101  C CA  . PRO A 1 49  ? 218.727 212.451 193.834 1.00 81.71  ? 89  PRO A CA  1 
ATOM 102  C C   . PRO A 1 49  ? 217.582 211.898 194.661 1.00 81.77  ? 89  PRO A C   1 
ATOM 103  O O   . PRO A 1 49  ? 216.507 212.512 194.738 1.00 82.66  ? 89  PRO A O   1 
ATOM 104  C CB  . PRO A 1 49  ? 219.629 213.369 194.671 1.00 78.09  ? 89  PRO A CB  1 
ATOM 105  C CG  . PRO A 1 49  ? 219.069 214.722 194.460 1.00 77.65  ? 89  PRO A CG  1 
ATOM 106  C CD  . PRO A 1 49  ? 218.564 214.747 193.045 1.00 81.11  ? 89  PRO A CD  1 
ATOM 107  N N   . PRO A 1 50  ? 217.768 210.740 195.290 1.00 77.89  ? 90  PRO A N   1 
ATOM 108  C CA  . PRO A 1 50  ? 216.700 210.160 196.110 1.00 78.08  ? 90  PRO A CA  1 
ATOM 109  C C   . PRO A 1 50  ? 216.426 211.010 197.340 1.00 78.92  ? 90  PRO A C   1 
ATOM 110  O O   . PRO A 1 50  ? 217.169 211.932 197.680 1.00 81.06  ? 90  PRO A O   1 
ATOM 111  C CB  . PRO A 1 50  ? 217.247 208.781 196.495 1.00 75.94  ? 90  PRO A CB  1 
ATOM 112  C CG  . PRO A 1 50  ? 218.388 208.531 195.560 1.00 72.90  ? 90  PRO A CG  1 
ATOM 113  C CD  . PRO A 1 50  ? 218.953 209.871 195.235 1.00 75.97  ? 90  PRO A CD  1 
ATOM 114  N N   . ALA A 1 51  ? 215.324 210.684 198.011 1.00 79.29  ? 91  ALA A N   1 
ATOM 115  C CA  . ALA A 1 51  ? 214.928 211.419 199.203 1.00 78.92  ? 91  ALA A CA  1 
ATOM 116  C C   . ALA A 1 51  ? 215.970 211.266 200.303 1.00 81.18  ? 91  ALA A C   1 
ATOM 117  O O   . ALA A 1 51  ? 216.478 210.170 200.552 1.00 87.90  ? 91  ALA A O   1 
ATOM 118  C CB  . ALA A 1 51  ? 213.569 210.929 199.698 1.00 79.75  ? 91  ALA A CB  1 
ATOM 119  N N   . ARG A 1 52  ? 216.285 212.376 200.965 1.00 77.28  ? 92  ARG A N   1 
ATOM 120  C CA  . ARG A 1 52  ? 217.290 212.377 202.015 1.00 73.67  ? 92  ARG A CA  1 
ATOM 121  C C   . ARG A 1 52  ? 216.911 213.406 203.066 1.00 80.53  ? 92  ARG A C   1 
ATOM 122  O O   . ARG A 1 52  ? 216.120 214.318 202.813 1.00 87.22  ? 92  ARG A O   1 
ATOM 123  C CB  . ARG A 1 52  ? 218.685 212.671 201.457 1.00 71.40  ? 92  ARG A CB  1 
ATOM 124  C CG  . ARG A 1 52  ? 218.847 214.072 200.904 1.00 68.25  ? 92  ARG A CG  1 
ATOM 125  C CD  . ARG A 1 52  ? 220.022 214.151 199.948 1.00 71.74  ? 92  ARG A CD  1 
ATOM 126  N NE  . ARG A 1 52  ? 220.233 212.897 199.237 1.00 81.17  ? 92  ARG A NE  1 
ATOM 127  C CZ  . ARG A 1 52  ? 221.342 212.587 198.579 1.00 83.44  ? 92  ARG A CZ  1 
ATOM 128  N NH1 . ARG A 1 52  ? 222.365 213.422 198.519 1.00 83.03  ? 92  ARG A NH1 1 
ATOM 129  N NH2 . ARG A 1 52  ? 221.424 211.411 197.965 1.00 81.71  ? 92  ARG A NH2 1 
ATOM 130  N N   . SER A 1 53  ? 217.484 213.246 204.256 1.00 81.72  ? 93  SER A N   1 
ATOM 131  C CA  . SER A 1 53  ? 217.234 214.166 205.355 1.00 80.51  ? 93  SER A CA  1 
ATOM 132  C C   . SER A 1 53  ? 218.502 214.315 206.178 1.00 80.16  ? 93  SER A C   1 
ATOM 133  O O   . SER A 1 53  ? 219.378 213.447 206.170 1.00 81.76  ? 93  SER A O   1 
ATOM 134  C CB  . SER A 1 53  ? 216.079 213.692 206.239 1.00 82.81  ? 93  SER A CB  1 
ATOM 135  O OG  . SER A 1 53  ? 215.941 214.526 207.374 1.00 85.42  ? 93  SER A OG  1 
ATOM 136  N N   . GLY A 1 54  ? 218.590 215.434 206.893 1.00 75.29  ? 94  GLY A N   1 
ATOM 137  C CA  . GLY A 1 54  ? 219.753 215.735 207.698 1.00 80.44  ? 94  GLY A CA  1 
ATOM 138  C C   . GLY A 1 54  ? 220.933 216.282 206.930 1.00 83.65  ? 94  GLY A C   1 
ATOM 139  O O   . GLY A 1 54  ? 221.975 216.554 207.538 1.00 89.99  ? 94  GLY A O   1 
ATOM 140  N N   . HIS A 1 55  ? 220.803 216.455 205.620 1.00 80.07  ? 95  HIS A N   1 
ATOM 141  C CA  . HIS A 1 55  ? 221.872 216.960 204.778 1.00 75.98  ? 95  HIS A CA  1 
ATOM 142  C C   . HIS A 1 55  ? 222.001 218.472 204.927 1.00 78.93  ? 95  HIS A C   1 
ATOM 143  O O   . HIS A 1 55  ? 221.211 219.127 205.611 1.00 83.33  ? 95  HIS A O   1 
ATOM 144  C CB  . HIS A 1 55  ? 221.609 216.601 203.319 1.00 76.78  ? 95  HIS A CB  1 
ATOM 145  C CG  . HIS A 1 55  ? 220.379 217.243 202.757 1.00 77.09  ? 95  HIS A CG  1 
ATOM 146  N ND1 . HIS A 1 55  ? 219.177 217.261 203.428 1.00 77.06  ? 95  HIS A ND1 1 
ATOM 147  C CD2 . HIS A 1 55  ? 220.168 217.896 201.591 1.00 80.26  ? 95  HIS A CD2 1 
ATOM 148  C CE1 . HIS A 1 55  ? 218.277 217.896 202.699 1.00 77.24  ? 95  HIS A CE1 1 
ATOM 149  N NE2 . HIS A 1 55  ? 218.853 218.291 201.579 1.00 79.92  ? 95  HIS A NE2 1 
ATOM 150  N N   . ARG A 1 56  ? 223.014 219.030 204.270 1.00 78.45  ? 96  ARG A N   1 
ATOM 151  C CA  . ARG A 1 56  ? 223.206 220.472 204.221 1.00 79.51  ? 96  ARG A CA  1 
ATOM 152  C C   . ARG A 1 56  ? 223.437 220.896 202.780 1.00 80.28  ? 96  ARG A C   1 
ATOM 153  O O   . ARG A 1 56  ? 223.799 220.087 201.925 1.00 82.09  ? 96  ARG A O   1 
ATOM 154  C CB  . ARG A 1 56  ? 224.381 220.926 205.095 1.00 77.83  ? 96  ARG A CB  1 
ATOM 155  C CG  . ARG A 1 56  ? 224.234 220.569 206.559 1.00 79.29  ? 96  ARG A CG  1 
ATOM 156  C CD  . ARG A 1 56  ? 223.022 221.233 207.184 1.00 77.88  ? 96  ARG A CD  1 
ATOM 157  N NE  . ARG A 1 56  ? 223.385 222.403 207.973 1.00 84.01  ? 96  ARG A NE  1 
ATOM 158  C CZ  . ARG A 1 56  ? 223.342 222.454 209.297 1.00 91.49  ? 96  ARG A CZ  1 
ATOM 159  N NH1 . ARG A 1 56  ? 222.969 221.410 210.017 1.00 89.05  ? 96  ARG A NH1 1 
ATOM 160  N NH2 . ARG A 1 56  ? 223.685 223.580 209.914 1.00 96.40  ? 96  ARG A NH2 1 
ATOM 161  N N   . CYS A 1 57  ? 223.197 222.176 202.507 1.00 80.80  ? 97  CYS A N   1 
ATOM 162  C CA  . CYS A 1 57  ? 223.425 222.700 201.171 1.00 80.29  ? 97  CYS A CA  1 
ATOM 163  C C   . CYS A 1 57  ? 223.855 224.155 201.252 1.00 82.46  ? 97  CYS A C   1 
ATOM 164  O O   . CYS A 1 57  ? 223.465 224.889 202.163 1.00 86.59  ? 97  CYS A O   1 
ATOM 165  C CB  . CYS A 1 57  ? 222.182 222.571 200.285 1.00 81.02  ? 97  CYS A CB  1 
ATOM 166  S SG  . CYS A 1 57  ? 220.648 223.120 201.040 1.00 93.41  ? 97  CYS A SG  1 
ATOM 167  N N   . VAL A 1 58  ? 224.668 224.555 200.278 1.00 82.30  ? 98  VAL A N   1 
ATOM 168  C CA  . VAL A 1 58  ? 225.102 225.932 200.110 1.00 81.62  ? 98  VAL A CA  1 
ATOM 169  C C   . VAL A 1 58  ? 224.915 226.289 198.643 1.00 82.92  ? 98  VAL A C   1 
ATOM 170  O O   . VAL A 1 58  ? 224.692 225.423 197.796 1.00 85.29  ? 98  VAL A O   1 
ATOM 171  C CB  . VAL A 1 58  ? 226.564 226.145 200.557 1.00 79.45  ? 98  VAL A CB  1 
ATOM 172  C CG1 . VAL A 1 58  ? 227.524 225.763 199.447 1.00 83.81  ? 98  VAL A CG1 1 
ATOM 173  C CG2 . VAL A 1 58  ? 226.780 227.579 201.012 1.00 86.24  ? 98  VAL A CG2 1 
ATOM 174  N N   . ALA A 1 59  ? 224.972 227.583 198.343 1.00 83.53  ? 99  ALA A N   1 
ATOM 175  C CA  . ALA A 1 59  ? 224.679 228.036 196.993 1.00 84.38  ? 99  ALA A CA  1 
ATOM 176  C C   . ALA A 1 59  ? 225.560 229.216 196.617 1.00 87.34  ? 99  ALA A C   1 
ATOM 177  O O   . ALA A 1 59  ? 225.918 230.044 197.458 1.00 89.53  ? 99  ALA A O   1 
ATOM 178  C CB  . ALA A 1 59  ? 223.205 228.428 196.843 1.00 84.73  ? 99  ALA A CB  1 
ATOM 179  N N   . ASP A 1 60  ? 225.907 229.274 195.332 1.00 90.21  ? 100 ASP A N   1 
ATOM 180  C CA  . ASP A 1 60  ? 226.533 230.448 194.740 1.00 94.15  ? 100 ASP A CA  1 
ATOM 181  C C   . ASP A 1 60  ? 225.732 230.856 193.511 1.00 97.52  ? 100 ASP A C   1 
ATOM 182  O O   . ASP A 1 60  ? 224.636 230.335 193.285 1.00 101.59 ? 100 ASP A O   1 
ATOM 183  C CB  . ASP A 1 60  ? 227.997 230.178 194.386 1.00 95.83  ? 100 ASP A CB  1 
ATOM 184  C CG  . ASP A 1 60  ? 228.153 229.275 193.182 1.00 98.58  ? 100 ASP A CG  1 
ATOM 185  O OD1 . ASP A 1 60  ? 227.308 228.379 192.991 1.00 97.10  ? 100 ASP A OD1 1 
ATOM 186  O OD2 . ASP A 1 60  ? 229.127 229.461 192.424 1.00 101.17 ? 100 ASP A OD2 1 
ATOM 187  N N   . ASN A 1 61  ? 226.258 231.782 192.711 1.00 98.61  ? 101 ASN A N   1 
ATOM 188  C CA  . ASN A 1 61  ? 225.508 232.276 191.562 1.00 100.88 ? 101 ASN A CA  1 
ATOM 189  C C   . ASN A 1 61  ? 225.344 231.238 190.458 1.00 97.72  ? 101 ASN A C   1 
ATOM 190  O O   . ASN A 1 61  ? 224.547 231.463 189.542 1.00 98.95  ? 101 ASN A O   1 
ATOM 191  C CB  . ASN A 1 61  ? 226.183 233.524 190.993 1.00 103.61 ? 101 ASN A CB  1 
ATOM 192  C CG  . ASN A 1 61  ? 227.598 233.258 190.526 1.00 108.73 ? 101 ASN A CG  1 
ATOM 193  O OD1 . ASN A 1 61  ? 228.230 232.290 190.947 1.00 110.18 ? 101 ASN A OD1 1 
ATOM 194  N ND2 . ASN A 1 61  ? 228.103 234.117 189.650 1.00 109.00 ? 101 ASN A ND2 1 
ATOM 195  N N   . THR A 1 62  ? 226.060 230.117 190.518 1.00 94.60  ? 102 THR A N   1 
ATOM 196  C CA  . THR A 1 62  ? 226.056 229.133 189.443 1.00 94.58  ? 102 THR A CA  1 
ATOM 197  C C   . THR A 1 62  ? 225.366 227.830 189.815 1.00 91.79  ? 102 THR A C   1 
ATOM 198  O O   . THR A 1 62  ? 224.468 227.382 189.097 1.00 92.74  ? 102 THR A O   1 
ATOM 199  C CB  . THR A 1 62  ? 227.493 228.839 188.994 1.00 95.06  ? 102 THR A CB  1 
ATOM 200  O OG1 . THR A 1 62  ? 228.126 230.057 188.584 1.00 99.09  ? 102 THR A OG1 1 
ATOM 201  C CG2 . THR A 1 62  ? 227.495 227.858 187.836 1.00 90.51  ? 102 THR A CG2 1 
ATOM 202  N N   . ASN A 1 63  ? 225.762 227.200 190.918 1.00 88.03  ? 103 ASN A N   1 
ATOM 203  C CA  . ASN A 1 63  ? 225.261 225.884 191.281 1.00 83.27  ? 103 ASN A CA  1 
ATOM 204  C C   . ASN A 1 63  ? 224.810 225.870 192.734 1.00 84.95  ? 103 ASN A C   1 
ATOM 205  O O   . ASN A 1 63  ? 225.161 226.745 193.528 1.00 90.40  ? 103 ASN A O   1 
ATOM 206  C CB  . ASN A 1 63  ? 226.324 224.800 191.069 1.00 85.35  ? 103 ASN A CB  1 
ATOM 207  C CG  . ASN A 1 63  ? 226.603 224.536 189.609 1.00 90.45  ? 103 ASN A CG  1 
ATOM 208  O OD1 . ASN A 1 63  ? 225.684 224.440 188.799 1.00 93.76  ? 103 ASN A OD1 1 
ATOM 209  N ND2 . ASN A 1 63  ? 227.877 224.411 189.264 1.00 95.04  ? 103 ASN A ND2 1 
ATOM 210  N N   . LEU A 1 64  ? 224.019 224.856 193.068 1.00 81.53  ? 104 LEU A N   1 
ATOM 211  C CA  . LEU A 1 64  ? 223.613 224.582 194.443 1.00 81.38  ? 104 LEU A CA  1 
ATOM 212  C C   . LEU A 1 64  ? 224.263 223.273 194.867 1.00 80.42  ? 104 LEU A C   1 
ATOM 213  O O   . LEU A 1 64  ? 223.970 222.221 194.294 1.00 83.47  ? 104 LEU A O   1 
ATOM 214  C CB  . LEU A 1 64  ? 222.094 224.499 194.562 1.00 77.76  ? 104 LEU A CB  1 
ATOM 215  C CG  . LEU A 1 64  ? 221.574 223.989 195.906 1.00 77.99  ? 104 LEU A CG  1 
ATOM 216  C CD1 . LEU A 1 64  ? 221.546 225.111 196.926 1.00 80.18  ? 104 LEU A CD1 1 
ATOM 217  C CD2 . LEU A 1 64  ? 220.200 223.368 195.750 1.00 81.11  ? 104 LEU A CD2 1 
ATOM 218  N N   . TYR A 1 65  ? 225.137 223.335 195.868 1.00 77.84  ? 105 TYR A N   1 
ATOM 219  C CA  . TYR A 1 65  ? 225.901 222.181 196.322 1.00 75.39  ? 105 TYR A CA  1 
ATOM 220  C C   . TYR A 1 65  ? 225.214 221.565 197.533 1.00 80.45  ? 105 TYR A C   1 
ATOM 221  O O   . TYR A 1 65  ? 224.959 222.255 198.525 1.00 87.92  ? 105 TYR A O   1 
ATOM 222  C CB  . TYR A 1 65  ? 227.332 222.586 196.665 1.00 73.78  ? 105 TYR A CB  1 
ATOM 223  C CG  . TYR A 1 65  ? 228.012 223.375 195.575 1.00 78.53  ? 105 TYR A CG  1 
ATOM 224  C CD1 . TYR A 1 65  ? 228.229 222.818 194.327 1.00 80.81  ? 105 TYR A CD1 1 
ATOM 225  C CD2 . TYR A 1 65  ? 228.433 224.677 195.790 1.00 85.21  ? 105 TYR A CD2 1 
ATOM 226  C CE1 . TYR A 1 65  ? 228.850 223.528 193.324 1.00 84.26  ? 105 TYR A CE1 1 
ATOM 227  C CE2 . TYR A 1 65  ? 229.055 225.399 194.792 1.00 90.33  ? 105 TYR A CE2 1 
ATOM 228  C CZ  . TYR A 1 65  ? 229.261 224.818 193.560 1.00 90.88  ? 105 TYR A CZ  1 
ATOM 229  O OH  . TYR A 1 65  ? 229.880 225.531 192.560 1.00 96.33  ? 105 TYR A OH  1 
ATOM 230  N N   . VAL A 1 66  ? 224.927 220.268 197.453 1.00 76.42  ? 106 VAL A N   1 
ATOM 231  C CA  . VAL A 1 66  ? 224.243 219.527 198.505 1.00 75.36  ? 106 VAL A CA  1 
ATOM 232  C C   . VAL A 1 66  ? 225.175 218.424 198.982 1.00 78.09  ? 106 VAL A C   1 
ATOM 233  O O   . VAL A 1 66  ? 225.632 217.602 198.179 1.00 80.66  ? 106 VAL A O   1 
ATOM 234  C CB  . VAL A 1 66  ? 222.914 218.936 198.010 1.00 70.42  ? 106 VAL A CB  1 
ATOM 235  C CG1 . VAL A 1 66  ? 222.402 217.896 198.986 1.00 69.18  ? 106 VAL A CG1 1 
ATOM 236  C CG2 . VAL A 1 66  ? 221.889 220.030 197.796 1.00 72.82  ? 106 VAL A CG2 1 
ATOM 237  N N   . PHE A 1 67  ? 225.448 218.397 200.283 1.00 76.25  ? 107 PHE A N   1 
ATOM 238  C CA  . PHE A 1 67  ? 226.313 217.395 200.880 1.00 72.92  ? 107 PHE A CA  1 
ATOM 239  C C   . PHE A 1 67  ? 225.576 216.661 201.991 1.00 77.56  ? 107 PHE A C   1 
ATOM 240  O O   . PHE A 1 67  ? 224.756 217.245 202.709 1.00 81.51  ? 107 PHE A O   1 
ATOM 241  C CB  . PHE A 1 67  ? 227.593 218.021 201.438 1.00 71.17  ? 107 PHE A CB  1 
ATOM 242  C CG  . PHE A 1 67  ? 228.491 217.041 202.129 1.00 74.75  ? 107 PHE A CG  1 
ATOM 243  C CD1 . PHE A 1 67  ? 229.068 215.999 201.426 1.00 79.49  ? 107 PHE A CD1 1 
ATOM 244  C CD2 . PHE A 1 67  ? 228.752 217.154 203.481 1.00 78.16  ? 107 PHE A CD2 1 
ATOM 245  C CE1 . PHE A 1 67  ? 229.892 215.093 202.059 1.00 83.49  ? 107 PHE A CE1 1 
ATOM 246  C CE2 . PHE A 1 67  ? 229.575 216.251 204.119 1.00 80.71  ? 107 PHE A CE2 1 
ATOM 247  C CZ  . PHE A 1 67  ? 230.146 215.219 203.407 1.00 81.78  ? 107 PHE A CZ  1 
ATOM 248  N N   . GLY A 1 68  ? 225.880 215.374 202.121 1.00 76.93  ? 108 GLY A N   1 
ATOM 249  C CA  . GLY A 1 68  ? 225.311 214.554 203.167 1.00 77.87  ? 108 GLY A CA  1 
ATOM 250  C C   . GLY A 1 68  ? 223.945 214.006 202.816 1.00 75.50  ? 108 GLY A C   1 
ATOM 251  O O   . GLY A 1 68  ? 223.500 214.008 201.665 1.00 77.40  ? 108 GLY A O   1 
ATOM 252  N N   . GLY A 1 69  ? 223.269 213.519 203.851 1.00 74.41  ? 109 GLY A N   1 
ATOM 253  C CA  . GLY A 1 69  ? 221.937 212.973 203.693 1.00 77.58  ? 109 GLY A CA  1 
ATOM 254  C C   . GLY A 1 69  ? 221.773 211.615 204.338 1.00 80.18  ? 109 GLY A C   1 
ATOM 255  O O   . GLY A 1 69  ? 222.689 210.789 204.300 1.00 83.74  ? 109 GLY A O   1 
ATOM 256  N N   . TYR A 1 70  ? 220.608 211.369 204.932 1.00 80.77  ? 110 TYR A N   1 
ATOM 257  C CA  . TYR A 1 70  ? 220.327 210.100 205.587 1.00 81.11  ? 110 TYR A CA  1 
ATOM 258  C C   . TYR A 1 70  ? 218.901 209.682 205.272 1.00 82.90  ? 110 TYR A C   1 
ATOM 259  O O   . TYR A 1 70  ? 217.982 210.503 205.341 1.00 81.01  ? 110 TYR A O   1 
ATOM 260  C CB  . TYR A 1 70  ? 220.537 210.207 207.102 1.00 81.06  ? 110 TYR A CB  1 
ATOM 261  C CG  . TYR A 1 70  ? 219.553 209.417 207.931 1.00 83.42  ? 110 TYR A CG  1 
ATOM 262  C CD1 . TYR A 1 70  ? 219.670 208.041 208.060 1.00 86.24  ? 110 TYR A CD1 1 
ATOM 263  C CD2 . TYR A 1 70  ? 218.514 210.050 208.597 1.00 82.74  ? 110 TYR A CD2 1 
ATOM 264  C CE1 . TYR A 1 70  ? 218.774 207.318 208.820 1.00 86.05  ? 110 TYR A CE1 1 
ATOM 265  C CE2 . TYR A 1 70  ? 217.615 209.336 209.359 1.00 81.80  ? 110 TYR A CE2 1 
ATOM 266  C CZ  . TYR A 1 70  ? 217.749 207.971 209.467 1.00 85.64  ? 110 TYR A CZ  1 
ATOM 267  O OH  . TYR A 1 70  ? 216.854 207.255 210.227 1.00 92.76  ? 110 TYR A OH  1 
ATOM 268  N N   . ASN A 1 71  ? 218.723 208.410 204.926 1.00 83.89  ? 111 ASN A N   1 
ATOM 269  C CA  . ASN A 1 71  ? 217.409 207.859 204.620 1.00 83.18  ? 111 ASN A CA  1 
ATOM 270  C C   . ASN A 1 71  ? 217.387 206.376 204.960 1.00 89.41  ? 111 ASN A C   1 
ATOM 271  O O   . ASN A 1 71  ? 218.102 205.584 204.334 1.00 93.15  ? 111 ASN A O   1 
ATOM 272  C CB  . ASN A 1 71  ? 217.057 208.073 203.149 1.00 82.45  ? 111 ASN A CB  1 
ATOM 273  C CG  . ASN A 1 71  ? 215.578 207.910 202.875 1.00 89.00  ? 111 ASN A CG  1 
ATOM 274  O OD1 . ASN A 1 71  ? 214.823 207.456 203.732 1.00 91.48  ? 111 ASN A OD1 1 
ATOM 275  N ND2 . ASN A 1 71  ? 215.154 208.283 201.675 1.00 94.91  ? 111 ASN A ND2 1 
ATOM 276  N N   . PRO A 1 72  ? 216.582 205.959 205.940 1.00 90.75  ? 112 PRO A N   1 
ATOM 277  C CA  . PRO A 1 72  ? 216.592 204.551 206.357 1.00 91.30  ? 112 PRO A CA  1 
ATOM 278  C C   . PRO A 1 72  ? 215.787 203.623 205.463 1.00 97.74  ? 112 PRO A C   1 
ATOM 279  O O   . PRO A 1 72  ? 215.859 202.403 205.656 1.00 101.24 ? 112 PRO A O   1 
ATOM 280  C CB  . PRO A 1 72  ? 215.989 204.609 207.763 1.00 88.06  ? 112 PRO A CB  1 
ATOM 281  C CG  . PRO A 1 72  ? 215.056 205.768 207.703 1.00 88.92  ? 112 PRO A CG  1 
ATOM 282  C CD  . PRO A 1 72  ? 215.672 206.774 206.764 1.00 88.58  ? 112 PRO A CD  1 
ATOM 283  N N   . ASP A 1 73  ? 215.024 204.144 204.507 1.00 100.56 ? 113 ASP A N   1 
ATOM 284  C CA  . ASP A 1 73  ? 214.212 203.296 203.643 1.00 101.28 ? 113 ASP A CA  1 
ATOM 285  C C   . ASP A 1 73  ? 215.112 202.615 202.620 1.00 102.18 ? 113 ASP A C   1 
ATOM 286  O O   . ASP A 1 73  ? 215.839 203.285 201.879 1.00 104.86 ? 113 ASP A O   1 
ATOM 287  C CB  . ASP A 1 73  ? 213.125 204.117 202.953 1.00 105.45 ? 113 ASP A CB  1 
ATOM 288  C CG  . ASP A 1 73  ? 212.051 203.251 202.316 1.00 112.91 ? 113 ASP A CG  1 
ATOM 289  O OD1 . ASP A 1 73  ? 212.380 202.167 201.792 1.00 111.09 ? 113 ASP A OD1 1 
ATOM 290  O OD2 . ASP A 1 73  ? 210.871 203.659 202.340 1.00 119.88 ? 113 ASP A OD2 1 
ATOM 291  N N   . TYR A 1 74  ? 215.058 201.283 202.575 1.00 101.56 ? 114 TYR A N   1 
ATOM 292  C CA  . TYR A 1 74  ? 215.952 200.531 201.701 1.00 103.59 ? 114 TYR A CA  1 
ATOM 293  C C   . TYR A 1 74  ? 215.610 200.751 200.233 1.00 106.59 ? 114 TYR A C   1 
ATOM 294  O O   . TYR A 1 74  ? 216.492 201.035 199.416 1.00 106.41 ? 114 TYR A O   1 
ATOM 295  C CB  . TYR A 1 74  ? 215.893 199.045 202.053 1.00 105.29 ? 114 TYR A CB  1 
ATOM 296  C CG  . TYR A 1 74  ? 217.047 198.243 201.503 1.00 112.50 ? 114 TYR A CG  1 
ATOM 297  C CD1 . TYR A 1 74  ? 218.345 198.471 201.938 1.00 112.78 ? 114 TYR A CD1 1 
ATOM 298  C CD2 . TYR A 1 74  ? 216.840 197.259 200.548 1.00 117.51 ? 114 TYR A CD2 1 
ATOM 299  C CE1 . TYR A 1 74  ? 219.403 197.741 201.437 1.00 117.62 ? 114 TYR A CE1 1 
ATOM 300  C CE2 . TYR A 1 74  ? 217.892 196.524 200.041 1.00 119.89 ? 114 TYR A CE2 1 
ATOM 301  C CZ  . TYR A 1 74  ? 219.171 196.768 200.489 1.00 121.92 ? 114 TYR A CZ  1 
ATOM 302  O OH  . TYR A 1 74  ? 220.221 196.037 199.986 1.00 120.06 ? 114 TYR A OH  1 
ATOM 303  N N   . ASP A 1 75  ? 214.330 200.625 199.880 1.00 109.98 ? 115 ASP A N   1 
ATOM 304  C CA  . ASP A 1 75  ? 213.935 200.751 198.481 1.00 113.78 ? 115 ASP A CA  1 
ATOM 305  C C   . ASP A 1 75  ? 214.121 202.175 197.974 1.00 111.52 ? 115 ASP A C   1 
ATOM 306  O O   . ASP A 1 75  ? 214.556 202.383 196.836 1.00 112.04 ? 115 ASP A O   1 
ATOM 307  C CB  . ASP A 1 75  ? 212.486 200.301 198.305 1.00 116.18 ? 115 ASP A CB  1 
ATOM 308  C CG  . ASP A 1 75  ? 212.156 199.074 199.129 1.00 118.06 ? 115 ASP A CG  1 
ATOM 309  O OD1 . ASP A 1 75  ? 212.591 197.966 198.749 1.00 113.63 ? 115 ASP A OD1 1 
ATOM 310  O OD2 . ASP A 1 75  ? 211.465 199.217 200.159 1.00 121.40 ? 115 ASP A OD2 1 
ATOM 311  N N   . GLU A 1 76  ? 213.786 203.168 198.799 1.00 107.94 ? 116 GLU A N   1 
ATOM 312  C CA  . GLU A 1 76  ? 213.926 204.557 198.380 1.00 104.52 ? 116 GLU A CA  1 
ATOM 313  C C   . GLU A 1 76  ? 215.386 204.931 198.158 1.00 102.28 ? 116 GLU A C   1 
ATOM 314  O O   . GLU A 1 76  ? 215.715 205.616 197.184 1.00 103.77 ? 116 GLU A O   1 
ATOM 315  C CB  . GLU A 1 76  ? 213.294 205.482 199.417 1.00 106.56 ? 116 GLU A CB  1 
ATOM 316  C CG  . GLU A 1 76  ? 212.038 206.184 198.946 1.00 110.53 ? 116 GLU A CG  1 
ATOM 317  C CD  . GLU A 1 76  ? 211.650 207.332 199.853 1.00 113.32 ? 116 GLU A CD  1 
ATOM 318  O OE1 . GLU A 1 76  ? 212.551 207.917 200.488 1.00 104.13 ? 116 GLU A OE1 1 
ATOM 319  O OE2 . GLU A 1 76  ? 210.444 207.646 199.937 1.00 121.73 ? 116 GLU A OE2 1 
ATOM 320  N N   . SER A 1 77  ? 216.274 204.492 199.045 1.00 100.05 ? 117 SER A N   1 
ATOM 321  C CA  . SER A 1 77  ? 217.671 204.923 199.016 1.00 100.32 ? 117 SER A CA  1 
ATOM 322  C C   . SER A 1 77  ? 218.526 204.051 198.100 1.00 106.88 ? 117 SER A C   1 
ATOM 323  O O   . SER A 1 77  ? 219.577 203.550 198.492 1.00 111.65 ? 117 SER A O   1 
ATOM 324  C CB  . SER A 1 77  ? 218.233 204.936 200.431 1.00 100.24 ? 117 SER A CB  1 
ATOM 325  O OG  . SER A 1 77  ? 219.648 204.991 200.412 1.00 102.10 ? 117 SER A OG  1 
ATOM 326  N N   . GLY A 1 78  ? 218.076 203.866 196.861 1.00 107.93 ? 118 GLY A N   1 
ATOM 327  C CA  . GLY A 1 78  ? 218.884 203.204 195.856 1.00 112.59 ? 118 GLY A CA  1 
ATOM 328  C C   . GLY A 1 78  ? 219.122 201.727 196.064 1.00 119.33 ? 118 GLY A C   1 
ATOM 329  O O   . GLY A 1 78  ? 219.896 201.131 195.308 1.00 118.16 ? 118 GLY A O   1 
ATOM 330  N N   . GLY A 1 79  ? 218.483 201.112 197.055 1.00 119.94 ? 119 GLY A N   1 
ATOM 331  C CA  . GLY A 1 79  ? 218.626 199.696 197.294 1.00 116.81 ? 119 GLY A CA  1 
ATOM 332  C C   . GLY A 1 79  ? 220.048 199.287 197.620 1.00 117.09 ? 119 GLY A C   1 
ATOM 333  O O   . GLY A 1 79  ? 220.798 200.018 198.275 1.00 113.17 ? 119 GLY A O   1 
ATOM 334  N N   . PRO A 1 80  ? 220.446 198.096 197.164 1.00 120.70 ? 120 PRO A N   1 
ATOM 335  C CA  . PRO A 1 80  ? 221.807 197.617 197.451 1.00 120.45 ? 120 PRO A CA  1 
ATOM 336  C C   . PRO A 1 80  ? 222.897 198.421 196.766 1.00 121.01 ? 120 PRO A C   1 
ATOM 337  O O   . PRO A 1 80  ? 224.067 198.289 197.147 1.00 117.35 ? 120 PRO A O   1 
ATOM 338  C CB  . PRO A 1 80  ? 221.783 196.170 196.944 1.00 117.79 ? 120 PRO A CB  1 
ATOM 339  C CG  . PRO A 1 80  ? 220.730 196.164 195.891 1.00 120.72 ? 120 PRO A CG  1 
ATOM 340  C CD  . PRO A 1 80  ? 219.681 197.141 196.345 1.00 121.89 ? 120 PRO A CD  1 
ATOM 341  N N   . ASP A 1 81  ? 222.559 199.237 195.764 1.00 121.59 ? 121 ASP A N   1 
ATOM 342  C CA  . ASP A 1 81  ? 223.575 200.036 195.086 1.00 118.91 ? 121 ASP A CA  1 
ATOM 343  C C   . ASP A 1 81  ? 224.226 201.037 196.031 1.00 117.76 ? 121 ASP A C   1 
ATOM 344  O O   . ASP A 1 81  ? 225.393 201.398 195.844 1.00 117.76 ? 121 ASP A O   1 
ATOM 345  C CB  . ASP A 1 81  ? 222.961 200.758 193.887 1.00 115.40 ? 121 ASP A CB  1 
ATOM 346  N N   . ASN A 1 82  ? 223.495 201.493 197.045 1.00 113.21 ? 122 ASN A N   1 
ATOM 347  C CA  . ASN A 1 82  ? 224.033 202.427 198.031 1.00 106.82 ? 122 ASN A CA  1 
ATOM 348  C C   . ASN A 1 82  ? 224.798 201.628 199.077 1.00 104.60 ? 122 ASN A C   1 
ATOM 349  O O   . ASN A 1 82  ? 224.206 201.039 199.983 1.00 104.72 ? 122 ASN A O   1 
ATOM 350  C CB  . ASN A 1 82  ? 222.913 203.243 198.664 1.00 102.29 ? 122 ASN A CB  1 
ATOM 351  C CG  . ASN A 1 82  ? 223.413 204.187 199.738 1.00 95.71  ? 122 ASN A CG  1 
ATOM 352  O OD1 . ASN A 1 82  ? 224.587 204.555 199.761 1.00 94.62  ? 122 ASN A OD1 1 
ATOM 353  N ND2 . ASN A 1 82  ? 222.521 204.586 200.634 1.00 92.23  ? 122 ASN A ND2 1 
ATOM 354  N N   . GLU A 1 83  ? 226.125 201.606 198.953 1.00 101.84 ? 123 GLU A N   1 
ATOM 355  C CA  . GLU A 1 83  ? 226.955 200.859 199.888 1.00 103.43 ? 123 GLU A CA  1 
ATOM 356  C C   . GLU A 1 83  ? 227.051 201.521 201.254 1.00 102.57 ? 123 GLU A C   1 
ATOM 357  O O   . GLU A 1 83  ? 227.482 200.867 202.209 1.00 106.71 ? 123 GLU A O   1 
ATOM 358  C CB  . GLU A 1 83  ? 228.357 200.671 199.308 1.00 101.70 ? 123 GLU A CB  1 
ATOM 359  N N   . ASP A 1 84  ? 226.663 202.790 201.373 1.00 97.48  ? 124 ASP A N   1 
ATOM 360  C CA  . ASP A 1 84  ? 226.743 203.522 202.629 1.00 94.41  ? 124 ASP A CA  1 
ATOM 361  C C   . ASP A 1 84  ? 225.381 203.689 203.294 1.00 91.73  ? 124 ASP A C   1 
ATOM 362  O O   . ASP A 1 84  ? 225.215 204.579 204.133 1.00 91.81  ? 124 ASP A O   1 
ATOM 363  C CB  . ASP A 1 84  ? 227.390 204.888 202.402 1.00 91.22  ? 124 ASP A CB  1 
ATOM 364  N N   . TYR A 1 85  ? 224.414 202.852 202.938 1.00 90.13  ? 125 TYR A N   1 
ATOM 365  C CA  . TYR A 1 85  ? 223.081 202.959 203.510 1.00 87.90  ? 125 TYR A CA  1 
ATOM 366  C C   . TYR A 1 85  ? 223.150 202.761 205.023 1.00 90.50  ? 125 TYR A C   1 
ATOM 367  O O   . TYR A 1 85  ? 223.909 201.912 205.503 1.00 93.16  ? 125 TYR A O   1 
ATOM 368  C CB  . TYR A 1 85  ? 222.157 201.919 202.870 1.00 90.94  ? 125 TYR A CB  1 
ATOM 369  C CG  . TYR A 1 85  ? 220.881 201.624 203.629 1.00 94.04  ? 125 TYR A CG  1 
ATOM 370  C CD1 . TYR A 1 85  ? 220.836 200.624 204.592 1.00 98.87  ? 125 TYR A CD1 1 
ATOM 371  C CD2 . TYR A 1 85  ? 219.715 202.327 203.363 1.00 93.96  ? 125 TYR A CD2 1 
ATOM 372  C CE1 . TYR A 1 85  ? 219.675 200.349 205.281 1.00 99.85  ? 125 TYR A CE1 1 
ATOM 373  C CE2 . TYR A 1 85  ? 218.548 202.057 204.047 1.00 96.52  ? 125 TYR A CE2 1 
ATOM 374  C CZ  . TYR A 1 85  ? 218.534 201.067 205.003 1.00 99.96  ? 125 TYR A CZ  1 
ATOM 375  O OH  . TYR A 1 85  ? 217.375 200.791 205.689 1.00 103.78 ? 125 TYR A OH  1 
ATOM 376  N N   . PRO A 1 86  ? 222.373 203.522 205.805 1.00 87.97  ? 126 PRO A N   1 
ATOM 377  C CA  . PRO A 1 86  ? 221.396 204.538 205.404 1.00 86.51  ? 126 PRO A CA  1 
ATOM 378  C C   . PRO A 1 86  ? 221.967 205.945 205.300 1.00 84.62  ? 126 PRO A C   1 
ATOM 379  O O   . PRO A 1 86  ? 221.266 206.914 205.570 1.00 83.03  ? 126 PRO A O   1 
ATOM 380  C CB  . PRO A 1 86  ? 220.359 204.448 206.523 1.00 86.90  ? 126 PRO A CB  1 
ATOM 381  C CG  . PRO A 1 86  ? 221.190 204.158 207.742 1.00 85.53  ? 126 PRO A CG  1 
ATOM 382  C CD  . PRO A 1 86  ? 222.358 203.316 207.264 1.00 88.09  ? 126 PRO A CD  1 
ATOM 383  N N   . LEU A 1 87  ? 223.229 206.099 204.916 1.00 81.87  ? 127 LEU A N   1 
ATOM 384  C CA  . LEU A 1 87  ? 223.846 207.408 204.765 1.00 79.68  ? 127 LEU A CA  1 
ATOM 385  C C   . LEU A 1 87  ? 224.154 207.664 203.298 1.00 83.06  ? 127 LEU A C   1 
ATOM 386  O O   . LEU A 1 87  ? 224.539 206.749 202.563 1.00 84.57  ? 127 LEU A O   1 
ATOM 387  C CB  . LEU A 1 87  ? 225.126 207.512 205.596 1.00 81.11  ? 127 LEU A CB  1 
ATOM 388  C CG  . LEU A 1 87  ? 224.956 207.584 207.113 1.00 81.65  ? 127 LEU A CG  1 
ATOM 389  C CD1 . LEU A 1 87  ? 226.308 207.520 207.795 1.00 87.13  ? 127 LEU A CD1 1 
ATOM 390  C CD2 . LEU A 1 87  ? 224.217 208.847 207.510 1.00 80.31  ? 127 LEU A CD2 1 
ATOM 391  N N   . PHE A 1 88  ? 223.978 208.911 202.874 1.00 80.25  ? 128 PHE A N   1 
ATOM 392  C CA  . PHE A 1 88  ? 224.197 209.311 201.487 1.00 77.82  ? 128 PHE A CA  1 
ATOM 393  C C   . PHE A 1 88  ? 225.557 209.992 201.399 1.00 79.59  ? 128 PHE A C   1 
ATOM 394  O O   . PHE A 1 88  ? 225.676 211.207 201.554 1.00 83.86  ? 128 PHE A O   1 
ATOM 395  C CB  . PHE A 1 88  ? 223.079 210.224 201.006 1.00 80.24  ? 128 PHE A CB  1 
ATOM 396  C CG  . PHE A 1 88  ? 221.833 209.495 200.609 1.00 79.29  ? 128 PHE A CG  1 
ATOM 397  C CD1 . PHE A 1 88  ? 221.853 208.575 199.579 1.00 82.42  ? 128 PHE A CD1 1 
ATOM 398  C CD2 . PHE A 1 88  ? 220.642 209.730 201.265 1.00 77.98  ? 128 PHE A CD2 1 
ATOM 399  C CE1 . PHE A 1 88  ? 220.709 207.904 199.214 1.00 84.52  ? 128 PHE A CE1 1 
ATOM 400  C CE2 . PHE A 1 88  ? 219.497 209.061 200.901 1.00 80.02  ? 128 PHE A CE2 1 
ATOM 401  C CZ  . PHE A 1 88  ? 219.530 208.149 199.875 1.00 83.79  ? 128 PHE A CZ  1 
ATOM 402  N N   . ARG A 1 89  ? 226.594 209.199 201.138 1.00 79.28  ? 129 ARG A N   1 
ATOM 403  C CA  . ARG A 1 89  ? 227.935 209.745 200.984 1.00 84.19  ? 129 ARG A CA  1 
ATOM 404  C C   . ARG A 1 89  ? 228.118 210.289 199.575 1.00 86.84  ? 129 ARG A C   1 
ATOM 405  O O   . ARG A 1 89  ? 229.073 209.927 198.881 1.00 92.40  ? 129 ARG A O   1 
ATOM 406  C CB  . ARG A 1 89  ? 228.991 208.681 201.286 1.00 88.80  ? 129 ARG A CB  1 
ATOM 407  C CG  . ARG A 1 89  ? 230.290 209.236 201.845 1.00 91.66  ? 129 ARG A CG  1 
ATOM 408  C CD  . ARG A 1 89  ? 231.327 208.142 202.016 1.00 94.37  ? 129 ARG A CD  1 
ATOM 409  N NE  . ARG A 1 89  ? 232.625 208.678 202.404 1.00 100.61 ? 129 ARG A NE  1 
ATOM 410  C CZ  . ARG A 1 89  ? 233.766 208.008 202.321 1.00 105.11 ? 129 ARG A CZ  1 
ATOM 411  N NH1 . ARG A 1 89  ? 233.807 206.769 201.861 1.00 107.77 ? 129 ARG A NH1 1 
ATOM 412  N NH2 . ARG A 1 89  ? 234.894 208.596 202.708 1.00 102.76 ? 129 ARG A NH2 1 
ATOM 413  N N   . GLU A 1 90  ? 227.208 211.158 199.146 1.00 85.16  ? 130 GLU A N   1 
ATOM 414  C CA  . GLU A 1 90  ? 227.230 211.724 197.808 1.00 84.70  ? 130 GLU A CA  1 
ATOM 415  C C   . GLU A 1 90  ? 227.164 213.239 197.897 1.00 83.23  ? 130 GLU A C   1 
ATOM 416  O O   . GLU A 1 90  ? 226.424 213.789 198.717 1.00 87.11  ? 130 GLU A O   1 
ATOM 417  C CB  . GLU A 1 90  ? 226.064 211.206 196.961 1.00 86.07  ? 130 GLU A CB  1 
ATOM 418  C CG  . GLU A 1 90  ? 225.697 209.755 197.213 1.00 87.49  ? 130 GLU A CG  1 
ATOM 419  C CD  . GLU A 1 90  ? 224.232 209.473 196.947 1.00 92.57  ? 130 GLU A CD  1 
ATOM 420  O OE1 . GLU A 1 90  ? 223.430 210.430 196.955 1.00 91.25  ? 130 GLU A OE1 1 
ATOM 421  O OE2 . GLU A 1 90  ? 223.883 208.294 196.728 1.00 98.57  ? 130 GLU A OE2 1 
ATOM 422  N N   . LEU A 1 91  ? 227.940 213.907 197.051 1.00 79.96  ? 131 LEU A N   1 
ATOM 423  C CA  . LEU A 1 91  ? 227.923 215.359 196.932 1.00 77.96  ? 131 LEU A CA  1 
ATOM 424  C C   . LEU A 1 91  ? 227.303 215.700 195.583 1.00 77.13  ? 131 LEU A C   1 
ATOM 425  O O   . LEU A 1 91  ? 227.869 215.376 194.534 1.00 83.77  ? 131 LEU A O   1 
ATOM 426  C CB  . LEU A 1 91  ? 229.332 215.933 197.064 1.00 79.44  ? 131 LEU A CB  1 
ATOM 427  C CG  . LEU A 1 91  ? 229.569 217.370 196.600 1.00 76.15  ? 131 LEU A CG  1 
ATOM 428  C CD1 . LEU A 1 91  ? 228.665 218.336 197.336 1.00 79.21  ? 131 LEU A CD1 1 
ATOM 429  C CD2 . LEU A 1 91  ? 231.024 217.749 196.802 1.00 80.55  ? 131 LEU A CD2 1 
ATOM 430  N N   . TRP A 1 92  ? 226.144 216.348 195.612 1.00 72.94  ? 132 TRP A N   1 
ATOM 431  C CA  . TRP A 1 92  ? 225.387 216.658 194.410 1.00 75.86  ? 132 TRP A CA  1 
ATOM 432  C C   . TRP A 1 92  ? 225.411 218.155 194.141 1.00 75.01  ? 132 TRP A C   1 
ATOM 433  O O   . TRP A 1 92  ? 225.723 218.960 195.020 1.00 76.75  ? 132 TRP A O   1 
ATOM 434  C CB  . TRP A 1 92  ? 223.939 216.179 194.537 1.00 76.22  ? 132 TRP A CB  1 
ATOM 435  C CG  . TRP A 1 92  ? 223.782 214.703 194.395 1.00 79.44  ? 132 TRP A CG  1 
ATOM 436  C CD1 . TRP A 1 92  ? 224.347 213.741 195.175 1.00 81.77  ? 132 TRP A CD1 1 
ATOM 437  C CD2 . TRP A 1 92  ? 223.006 214.015 193.409 1.00 81.93  ? 132 TRP A CD2 1 
ATOM 438  N NE1 . TRP A 1 92  ? 223.972 212.496 194.737 1.00 84.10  ? 132 TRP A NE1 1 
ATOM 439  C CE2 . TRP A 1 92  ? 223.148 212.637 193.652 1.00 82.96  ? 132 TRP A CE2 1 
ATOM 440  C CE3 . TRP A 1 92  ? 222.205 214.431 192.343 1.00 86.66  ? 132 TRP A CE3 1 
ATOM 441  C CZ2 . TRP A 1 92  ? 222.520 211.674 192.871 1.00 85.68  ? 132 TRP A CZ2 1 
ATOM 442  C CZ3 . TRP A 1 92  ? 221.583 213.473 191.569 1.00 87.03  ? 132 TRP A CZ3 1 
ATOM 443  C CH2 . TRP A 1 92  ? 221.744 212.111 191.836 1.00 85.30  ? 132 TRP A CH2 1 
ATOM 444  N N   . ARG A 1 93  ? 225.070 218.526 192.910 1.00 74.65  ? 133 ARG A N   1 
ATOM 445  C CA  . ARG A 1 93  ? 224.966 219.929 192.547 1.00 75.55  ? 133 ARG A CA  1 
ATOM 446  C C   . ARG A 1 93  ? 223.831 220.123 191.556 1.00 77.66  ? 133 ARG A C   1 
ATOM 447  O O   . ARG A 1 93  ? 223.667 219.343 190.616 1.00 82.36  ? 133 ARG A O   1 
ATOM 448  C CB  . ARG A 1 93  ? 226.276 220.463 191.955 1.00 74.08  ? 133 ARG A CB  1 
ATOM 449  C CG  . ARG A 1 93  ? 226.796 219.690 190.759 1.00 80.60  ? 133 ARG A CG  1 
ATOM 450  C CD  . ARG A 1 93  ? 227.849 220.490 190.012 1.00 90.99  ? 133 ARG A CD  1 
ATOM 451  N NE  . ARG A 1 93  ? 227.349 221.006 188.744 1.00 91.62  ? 133 ARG A NE  1 
ATOM 452  C CZ  . ARG A 1 93  ? 227.641 220.489 187.559 1.00 88.48  ? 133 ARG A CZ  1 
ATOM 453  N NH1 . ARG A 1 93  ? 228.434 219.437 187.442 1.00 84.24  ? 133 ARG A NH1 1 
ATOM 454  N NH2 . ARG A 1 93  ? 227.124 221.039 186.466 1.00 87.11  ? 133 ARG A NH2 1 
ATOM 455  N N   . TYR A 1 94  ? 223.053 221.170 191.780 1.00 74.48  ? 134 TYR A N   1 
ATOM 456  C CA  . TYR A 1 94  ? 221.974 221.564 190.887 1.00 73.64  ? 134 TYR A CA  1 
ATOM 457  C C   . TYR A 1 94  ? 222.442 222.744 190.052 1.00 81.19  ? 134 TYR A C   1 
ATOM 458  O O   . TYR A 1 94  ? 222.915 223.744 190.603 1.00 86.63  ? 134 TYR A O   1 
ATOM 459  C CB  . TYR A 1 94  ? 220.724 221.937 191.683 1.00 73.83  ? 134 TYR A CB  1 
ATOM 460  C CG  . TYR A 1 94  ? 219.513 222.244 190.837 1.00 75.50  ? 134 TYR A CG  1 
ATOM 461  C CD1 . TYR A 1 94  ? 218.871 221.246 190.121 1.00 74.26  ? 134 TYR A CD1 1 
ATOM 462  C CD2 . TYR A 1 94  ? 219.004 223.531 190.763 1.00 76.42  ? 134 TYR A CD2 1 
ATOM 463  C CE1 . TYR A 1 94  ? 217.763 221.522 189.352 1.00 71.48  ? 134 TYR A CE1 1 
ATOM 464  C CE2 . TYR A 1 94  ? 217.896 223.816 189.998 1.00 74.31  ? 134 TYR A CE2 1 
ATOM 465  C CZ  . TYR A 1 94  ? 217.279 222.807 189.294 1.00 71.61  ? 134 TYR A CZ  1 
ATOM 466  O OH  . TYR A 1 94  ? 216.173 223.084 188.527 1.00 77.50  ? 134 TYR A OH  1 
ATOM 467  N N   . HIS A 1 95  ? 222.329 222.620 188.731 1.00 78.94  ? 135 HIS A N   1 
ATOM 468  C CA  . HIS A 1 95  ? 222.737 223.679 187.815 1.00 78.81  ? 135 HIS A CA  1 
ATOM 469  C C   . HIS A 1 95  ? 221.535 224.576 187.550 1.00 80.70  ? 135 HIS A C   1 
ATOM 470  O O   . HIS A 1 95  ? 220.560 224.148 186.927 1.00 84.51  ? 135 HIS A O   1 
ATOM 471  C CB  . HIS A 1 95  ? 223.284 223.086 186.520 1.00 80.79  ? 135 HIS A CB  1 
ATOM 472  C CG  . HIS A 1 95  ? 224.103 224.046 185.715 1.00 87.52  ? 135 HIS A CG  1 
ATOM 473  N ND1 . HIS A 1 95  ? 223.541 224.972 184.864 1.00 89.50  ? 135 HIS A ND1 1 
ATOM 474  C CD2 . HIS A 1 95  ? 225.442 224.221 185.629 1.00 92.36  ? 135 HIS A CD2 1 
ATOM 475  C CE1 . HIS A 1 95  ? 224.499 225.678 184.290 1.00 93.66  ? 135 HIS A CE1 1 
ATOM 476  N NE2 . HIS A 1 95  ? 225.662 225.242 184.738 1.00 95.16  ? 135 HIS A NE2 1 
ATOM 477  N N   . PHE A 1 96  ? 221.608 225.824 188.020 1.00 80.12  ? 136 PHE A N   1 
ATOM 478  C CA  . PHE A 1 96  ? 220.456 226.716 187.932 1.00 81.04  ? 136 PHE A CA  1 
ATOM 479  C C   . PHE A 1 96  ? 220.057 226.977 186.486 1.00 86.83  ? 136 PHE A C   1 
ATOM 480  O O   . PHE A 1 96  ? 218.867 226.975 186.154 1.00 88.63  ? 136 PHE A O   1 
ATOM 481  C CB  . PHE A 1 96  ? 220.758 228.035 188.640 1.00 79.84  ? 136 PHE A CB  1 
ATOM 482  C CG  . PHE A 1 96  ? 221.091 227.880 190.091 1.00 82.58  ? 136 PHE A CG  1 
ATOM 483  C CD1 . PHE A 1 96  ? 220.409 226.972 190.877 1.00 83.97  ? 136 PHE A CD1 1 
ATOM 484  C CD2 . PHE A 1 96  ? 222.085 228.644 190.670 1.00 86.84  ? 136 PHE A CD2 1 
ATOM 485  C CE1 . PHE A 1 96  ? 220.716 226.827 192.212 1.00 87.31  ? 136 PHE A CE1 1 
ATOM 486  C CE2 . PHE A 1 96  ? 222.395 228.504 192.003 1.00 89.22  ? 136 PHE A CE2 1 
ATOM 487  C CZ  . PHE A 1 96  ? 221.710 227.596 192.776 1.00 87.47  ? 136 PHE A CZ  1 
ATOM 488  N N   . ALA A 1 97  ? 221.038 227.211 185.613 1.00 87.71  ? 137 ALA A N   1 
ATOM 489  C CA  . ALA A 1 97  ? 220.731 227.589 184.238 1.00 88.20  ? 137 ALA A CA  1 
ATOM 490  C C   . ALA A 1 97  ? 220.048 226.457 183.481 1.00 86.64  ? 137 ALA A C   1 
ATOM 491  O O   . ALA A 1 97  ? 219.065 226.687 182.768 1.00 88.49  ? 137 ALA A O   1 
ATOM 492  C CB  . ALA A 1 97  ? 222.007 228.023 183.519 1.00 94.89  ? 137 ALA A CB  1 
ATOM 493  N N   . THR A 1 98  ? 220.548 225.231 183.621 1.00 84.18  ? 138 THR A N   1 
ATOM 494  C CA  . THR A 1 98  ? 220.009 224.102 182.878 1.00 85.44  ? 138 THR A CA  1 
ATOM 495  C C   . THR A 1 98  ? 218.998 223.279 183.664 1.00 87.47  ? 138 THR A C   1 
ATOM 496  O O   . THR A 1 98  ? 218.274 222.482 183.059 1.00 90.41  ? 138 THR A O   1 
ATOM 497  C CB  . THR A 1 98  ? 221.143 223.182 182.412 1.00 84.91  ? 138 THR A CB  1 
ATOM 498  O OG1 . THR A 1 98  ? 222.046 222.949 183.498 1.00 89.67  ? 138 THR A OG1 1 
ATOM 499  C CG2 . THR A 1 98  ? 221.901 223.820 181.263 1.00 85.05  ? 138 THR A CG2 1 
ATOM 500  N N   . GLY A 1 99  ? 218.923 223.452 184.979 1.00 84.26  ? 139 GLY A N   1 
ATOM 501  C CA  . GLY A 1 99  ? 217.994 222.661 185.772 1.00 81.05  ? 139 GLY A CA  1 
ATOM 502  C C   . GLY A 1 99  ? 218.311 221.182 185.778 1.00 83.04  ? 139 GLY A C   1 
ATOM 503  O O   . GLY A 1 99  ? 217.407 220.354 185.617 1.00 87.03  ? 139 GLY A O   1 
ATOM 504  N N   . VAL A 1 100 ? 219.581 220.830 185.957 1.00 82.62  ? 140 VAL A N   1 
ATOM 505  C CA  . VAL A 1 100 ? 220.032 219.445 185.919 1.00 80.87  ? 140 VAL A CA  1 
ATOM 506  C C   . VAL A 1 100 ? 220.796 219.140 187.199 1.00 83.32  ? 140 VAL A C   1 
ATOM 507  O O   . VAL A 1 100 ? 221.538 219.987 187.711 1.00 84.47  ? 140 VAL A O   1 
ATOM 508  C CB  . VAL A 1 100 ? 220.911 219.165 184.681 1.00 81.59  ? 140 VAL A CB  1 
ATOM 509  C CG1 . VAL A 1 100 ? 221.172 217.676 184.538 1.00 84.89  ? 140 VAL A CG1 1 
ATOM 510  C CG2 . VAL A 1 100 ? 220.252 219.707 183.427 1.00 84.18  ? 140 VAL A CG2 1 
ATOM 511  N N   . TRP A 1 101 ? 220.603 217.931 187.720 1.00 83.87  ? 141 TRP A N   1 
ATOM 512  C CA  . TRP A 1 101 ? 221.315 217.448 188.895 1.00 84.18  ? 141 TRP A CA  1 
ATOM 513  C C   . TRP A 1 101 ? 222.520 216.626 188.456 1.00 82.92  ? 141 TRP A C   1 
ATOM 514  O O   . TRP A 1 101 ? 222.380 215.684 187.670 1.00 85.38  ? 141 TRP A O   1 
ATOM 515  C CB  . TRP A 1 101 ? 220.398 216.599 189.776 1.00 81.75  ? 141 TRP A CB  1 
ATOM 516  C CG  . TRP A 1 101 ? 219.408 217.389 190.572 1.00 79.98  ? 141 TRP A CG  1 
ATOM 517  C CD1 . TRP A 1 101 ? 218.163 217.779 190.177 1.00 80.17  ? 141 TRP A CD1 1 
ATOM 518  C CD2 . TRP A 1 101 ? 219.576 217.878 191.907 1.00 76.91  ? 141 TRP A CD2 1 
ATOM 519  N NE1 . TRP A 1 101 ? 217.547 218.483 191.181 1.00 77.67  ? 141 TRP A NE1 1 
ATOM 520  C CE2 . TRP A 1 101 ? 218.394 218.558 192.254 1.00 74.92  ? 141 TRP A CE2 1 
ATOM 521  C CE3 . TRP A 1 101 ? 220.613 217.807 192.842 1.00 76.73  ? 141 TRP A CE3 1 
ATOM 522  C CZ2 . TRP A 1 101 ? 218.221 219.165 193.493 1.00 75.22  ? 141 TRP A CZ2 1 
ATOM 523  C CZ3 . TRP A 1 101 ? 220.438 218.409 194.070 1.00 77.99  ? 141 TRP A CZ3 1 
ATOM 524  C CH2 . TRP A 1 101 ? 219.253 219.079 194.386 1.00 77.19  ? 141 TRP A CH2 1 
ATOM 525  N N   . HIS A 1 102 ? 223.697 216.980 188.966 1.00 79.24  ? 142 HIS A N   1 
ATOM 526  C CA  . HIS A 1 102 ? 224.934 216.281 188.652 1.00 79.78  ? 142 HIS A CA  1 
ATOM 527  C C   . HIS A 1 102 ? 225.573 215.805 189.945 1.00 81.76  ? 142 HIS A C   1 
ATOM 528  O O   . HIS A 1 102 ? 225.764 216.596 190.872 1.00 83.28  ? 142 HIS A O   1 
ATOM 529  C CB  . HIS A 1 102 ? 225.910 217.185 187.893 1.00 81.82  ? 142 HIS A CB  1 
ATOM 530  C CG  . HIS A 1 102 ? 225.500 217.477 186.484 1.00 81.78  ? 142 HIS A CG  1 
ATOM 531  N ND1 . HIS A 1 102 ? 224.770 218.594 186.137 1.00 81.96  ? 142 HIS A ND1 1 
ATOM 532  C CD2 . HIS A 1 102 ? 225.727 216.804 185.332 1.00 81.06  ? 142 HIS A CD2 1 
ATOM 533  C CE1 . HIS A 1 102 ? 224.561 218.593 184.833 1.00 84.67  ? 142 HIS A CE1 1 
ATOM 534  N NE2 . HIS A 1 102 ? 225.131 217.517 184.321 1.00 85.39  ? 142 HIS A NE2 1 
ATOM 535  N N   . GLN A 1 103 ? 225.911 214.521 190.004 1.00 84.43  ? 143 GLN A N   1 
ATOM 536  C CA  . GLN A 1 103 ? 226.607 213.960 191.154 1.00 84.74  ? 143 GLN A CA  1 
ATOM 537  C C   . GLN A 1 103 ? 228.107 214.041 190.906 1.00 83.67  ? 143 GLN A C   1 
ATOM 538  O O   . GLN A 1 103 ? 228.623 213.402 189.983 1.00 88.16  ? 143 GLN A O   1 
ATOM 539  C CB  . GLN A 1 103 ? 226.177 212.515 191.398 1.00 84.03  ? 143 GLN A CB  1 
ATOM 540  C CG  . GLN A 1 103 ? 227.010 211.797 192.443 1.00 89.11  ? 143 GLN A CG  1 
ATOM 541  C CD  . GLN A 1 103 ? 226.429 210.453 192.828 1.00 93.45  ? 143 GLN A CD  1 
ATOM 542  O OE1 . GLN A 1 103 ? 225.237 210.207 192.652 1.00 91.72  ? 143 GLN A OE1 1 
ATOM 543  N NE2 . GLN A 1 103 ? 227.271 209.574 193.356 1.00 97.49  ? 143 GLN A NE2 1 
ATOM 544  N N   . MET A 1 104 ? 228.803 214.824 191.725 1.00 79.54  ? 144 MET A N   1 
ATOM 545  C CA  . MET A 1 104 ? 230.226 215.046 191.507 1.00 88.38  ? 144 MET A CA  1 
ATOM 546  C C   . MET A 1 104 ? 231.023 213.776 191.764 1.00 95.96  ? 144 MET A C   1 
ATOM 547  O O   . MET A 1 104 ? 230.821 213.094 192.773 1.00 94.49  ? 144 MET A O   1 
ATOM 548  C CB  . MET A 1 104 ? 230.740 216.163 192.408 1.00 92.88  ? 144 MET A CB  1 
ATOM 549  C CG  . MET A 1 104 ? 230.200 217.532 192.091 1.00 93.27  ? 144 MET A CG  1 
ATOM 550  S SD  . MET A 1 104 ? 230.875 218.741 193.237 1.00 101.82 ? 144 MET A SD  1 
ATOM 551  C CE  . MET A 1 104 ? 229.575 219.957 193.222 1.00 86.58  ? 144 MET A CE  1 
ATOM 552  N N   . GLY A 1 105 ? 231.932 213.465 190.846 1.00 105.94 ? 145 GLY A N   1 
ATOM 553  C CA  . GLY A 1 105 ? 232.877 212.387 191.045 1.00 111.54 ? 145 GLY A CA  1 
ATOM 554  C C   . GLY A 1 105 ? 234.178 212.892 191.630 1.00 113.53 ? 145 GLY A C   1 
ATOM 555  O O   . GLY A 1 105 ? 235.230 212.808 190.989 1.00 118.05 ? 145 GLY A O   1 
ATOM 556  N N   . THR A 1 106 ? 234.118 213.426 192.846 1.00 108.30 ? 146 THR A N   1 
ATOM 557  C CA  . THR A 1 106 ? 235.294 214.002 193.474 1.00 109.99 ? 146 THR A CA  1 
ATOM 558  C C   . THR A 1 106 ? 236.302 212.913 193.834 1.00 112.27 ? 146 THR A C   1 
ATOM 559  O O   . THR A 1 106 ? 236.035 211.712 193.734 1.00 114.38 ? 146 THR A O   1 
ATOM 560  C CB  . THR A 1 106 ? 234.907 214.782 194.728 1.00 110.76 ? 146 THR A CB  1 
ATOM 561  O OG1 . THR A 1 106 ? 234.894 213.895 195.852 1.00 113.34 ? 146 THR A OG1 1 
ATOM 562  C CG2 . THR A 1 106 ? 233.532 215.397 194.565 1.00 105.80 ? 146 THR A CG2 1 
ATOM 563  N N   . ASP A 1 107 ? 237.478 213.351 194.262 1.00 111.12 ? 147 ASP A N   1 
ATOM 564  C CA  . ASP A 1 107 ? 238.551 212.465 194.687 1.00 114.03 ? 147 ASP A CA  1 
ATOM 565  C C   . ASP A 1 107 ? 238.863 212.728 196.159 1.00 110.70 ? 147 ASP A C   1 
ATOM 566  O O   . ASP A 1 107 ? 238.168 213.487 196.838 1.00 108.56 ? 147 ASP A O   1 
ATOM 567  C CB  . ASP A 1 107 ? 239.785 212.652 193.801 1.00 118.33 ? 147 ASP A CB  1 
ATOM 568  C CG  . ASP A 1 107 ? 240.582 213.888 194.166 1.00 123.21 ? 147 ASP A CG  1 
ATOM 569  O OD1 . ASP A 1 107 ? 239.963 214.946 194.404 1.00 121.14 ? 147 ASP A OD1 1 
ATOM 570  O OD2 . ASP A 1 107 ? 241.827 213.803 194.217 1.00 121.75 ? 147 ASP A OD2 1 
ATOM 571  N N   . GLY A 1 108 ? 239.922 212.091 196.650 1.00 108.40 ? 148 GLY A N   1 
ATOM 572  C CA  . GLY A 1 108 ? 240.321 212.288 198.028 1.00 106.16 ? 148 GLY A CA  1 
ATOM 573  C C   . GLY A 1 108 ? 239.534 211.411 198.988 1.00 104.68 ? 148 GLY A C   1 
ATOM 574  O O   . GLY A 1 108 ? 239.134 210.291 198.667 1.00 102.93 ? 148 GLY A O   1 
ATOM 575  N N   . TYR A 1 109 ? 239.311 211.941 200.186 1.00 103.44 ? 149 TYR A N   1 
ATOM 576  C CA  . TYR A 1 109 ? 238.652 211.215 201.269 1.00 102.45 ? 149 TYR A CA  1 
ATOM 577  C C   . TYR A 1 109 ? 237.414 211.996 201.696 1.00 98.05  ? 149 TYR A C   1 
ATOM 578  O O   . TYR A 1 109 ? 237.520 213.006 202.397 1.00 99.69  ? 149 TYR A O   1 
ATOM 579  C CB  . TYR A 1 109 ? 239.610 211.010 202.438 1.00 105.85 ? 149 TYR A CB  1 
ATOM 580  C CG  . TYR A 1 109 ? 239.013 210.258 203.602 1.00 109.77 ? 149 TYR A CG  1 
ATOM 581  C CD1 . TYR A 1 109 ? 238.269 209.104 203.400 1.00 111.00 ? 149 TYR A CD1 1 
ATOM 582  C CD2 . TYR A 1 109 ? 239.200 210.698 204.904 1.00 108.66 ? 149 TYR A CD2 1 
ATOM 583  C CE1 . TYR A 1 109 ? 237.724 208.412 204.462 1.00 112.20 ? 149 TYR A CE1 1 
ATOM 584  C CE2 . TYR A 1 109 ? 238.659 210.013 205.972 1.00 115.44 ? 149 TYR A CE2 1 
ATOM 585  C CZ  . TYR A 1 109 ? 237.923 208.871 205.746 1.00 118.84 ? 149 TYR A CZ  1 
ATOM 586  O OH  . TYR A 1 109 ? 237.384 208.187 206.810 1.00 121.17 ? 149 TYR A OH  1 
ATOM 587  N N   . MET A 1 110 ? 236.248 211.530 201.274 1.00 94.51  ? 150 MET A N   1 
ATOM 588  C CA  . MET A 1 110 ? 235.002 212.153 201.699 1.00 92.53  ? 150 MET A CA  1 
ATOM 589  C C   . MET A 1 110 ? 234.757 211.850 203.172 1.00 96.13  ? 150 MET A C   1 
ATOM 590  O O   . MET A 1 110 ? 234.890 210.695 203.591 1.00 100.71 ? 150 MET A O   1 
ATOM 591  C CB  . MET A 1 110 ? 233.838 211.649 200.851 1.00 93.06  ? 150 MET A CB  1 
ATOM 592  C CG  . MET A 1 110 ? 232.519 212.354 201.117 1.00 94.01  ? 150 MET A CG  1 
ATOM 593  S SD  . MET A 1 110 ? 231.598 212.722 199.613 1.00 99.49  ? 150 MET A SD  1 
ATOM 594  C CE  . MET A 1 110 ? 232.164 211.411 198.534 1.00 96.50  ? 150 MET A CE  1 
ATOM 595  N N   . PRO A 1 111 ? 234.415 212.847 203.987 1.00 91.41  ? 151 PRO A N   1 
ATOM 596  C CA  . PRO A 1 111 ? 234.193 212.587 205.413 1.00 93.42  ? 151 PRO A CA  1 
ATOM 597  C C   . PRO A 1 111 ? 233.024 211.641 205.638 1.00 97.86  ? 151 PRO A C   1 
ATOM 598  O O   . PRO A 1 111 ? 232.026 211.666 204.916 1.00 101.70 ? 151 PRO A O   1 
ATOM 599  C CB  . PRO A 1 111 ? 233.905 213.979 205.986 1.00 91.61  ? 151 PRO A CB  1 
ATOM 600  C CG  . PRO A 1 111 ? 233.424 214.772 204.820 1.00 87.50  ? 151 PRO A CG  1 
ATOM 601  C CD  . PRO A 1 111 ? 234.183 214.257 203.638 1.00 89.82  ? 151 PRO A CD  1 
ATOM 602  N N   . ARG A 1 112 ? 233.158 210.800 206.664 1.00 97.53  ? 152 ARG A N   1 
ATOM 603  C CA  . ARG A 1 112 ? 232.132 209.815 206.979 1.00 97.81  ? 152 ARG A CA  1 
ATOM 604  C C   . ARG A 1 112 ? 230.969 210.392 207.772 1.00 94.63  ? 152 ARG A C   1 
ATOM 605  O O   . ARG A 1 112 ? 229.924 209.740 207.864 1.00 96.37  ? 152 ARG A O   1 
ATOM 606  C CB  . ARG A 1 112 ? 232.746 208.648 207.754 1.00 103.57 ? 152 ARG A CB  1 
ATOM 607  C CG  . ARG A 1 112 ? 234.198 208.376 207.409 1.00 109.46 ? 152 ARG A CG  1 
ATOM 608  C CD  . ARG A 1 112 ? 234.317 207.520 206.159 1.00 108.53 ? 152 ARG A CD  1 
ATOM 609  N NE  . ARG A 1 112 ? 233.295 206.483 206.108 1.00 110.46 ? 152 ARG A NE  1 
ATOM 610  C CZ  . ARG A 1 112 ? 233.410 205.353 205.424 1.00 111.14 ? 152 ARG A CZ  1 
ATOM 611  N NH1 . ARG A 1 112 ? 234.497 205.078 204.722 1.00 109.87 ? 152 ARG A NH1 1 
ATOM 612  N NH2 . ARG A 1 112 ? 232.411 204.476 205.446 1.00 115.21 ? 152 ARG A NH2 1 
ATOM 613  N N   . GLU A 1 113 ? 231.117 211.585 208.342 1.00 93.50  ? 153 GLU A N   1 
ATOM 614  C CA  . GLU A 1 113 ? 230.040 212.217 209.097 1.00 89.87  ? 153 GLU A CA  1 
ATOM 615  C C   . GLU A 1 113 ? 229.067 212.852 208.113 1.00 86.77  ? 153 GLU A C   1 
ATOM 616  O O   . GLU A 1 113 ? 229.295 213.966 207.632 1.00 87.83  ? 153 GLU A O   1 
ATOM 617  C CB  . GLU A 1 113 ? 230.601 213.251 210.067 1.00 90.85  ? 153 GLU A CB  1 
ATOM 618  C CG  . GLU A 1 113 ? 231.569 212.678 211.085 1.00 96.38  ? 153 GLU A CG  1 
ATOM 619  C CD  . GLU A 1 113 ? 232.998 212.666 210.587 1.00 100.67 ? 153 GLU A CD  1 
ATOM 620  O OE1 . GLU A 1 113 ? 233.473 213.719 210.114 1.00 98.93  ? 153 GLU A OE1 1 
ATOM 621  O OE2 . GLU A 1 113 ? 233.647 211.603 210.667 1.00 105.90 ? 153 GLU A OE2 1 
ATOM 622  N N   . LEU A 1 114 ? 227.979 212.146 207.816 1.00 82.75  ? 154 LEU A N   1 
ATOM 623  C CA  . LEU A 1 114 ? 227.065 212.542 206.759 1.00 80.95  ? 154 LEU A CA  1 
ATOM 624  C C   . LEU A 1 114 ? 225.694 212.965 207.262 1.00 82.76  ? 154 LEU A C   1 
ATOM 625  O O   . LEU A 1 114 ? 224.807 213.227 206.441 1.00 83.20  ? 154 LEU A O   1 
ATOM 626  C CB  . LEU A 1 114 ? 226.909 211.398 205.751 1.00 81.20  ? 154 LEU A CB  1 
ATOM 627  C CG  . LEU A 1 114 ? 228.234 210.852 205.220 1.00 81.95  ? 154 LEU A CG  1 
ATOM 628  C CD1 . LEU A 1 114 ? 228.062 209.436 204.712 1.00 80.66  ? 154 LEU A CD1 1 
ATOM 629  C CD2 . LEU A 1 114 ? 228.779 211.753 204.127 1.00 81.02  ? 154 LEU A CD2 1 
ATOM 630  N N   . ALA A 1 115 ? 225.489 213.043 208.573 1.00 84.72  ? 155 ALA A N   1 
ATOM 631  C CA  . ALA A 1 115 ? 224.221 213.482 209.138 1.00 83.33  ? 155 ALA A CA  1 
ATOM 632  C C   . ALA A 1 115 ? 224.476 214.610 210.122 1.00 81.29  ? 155 ALA A C   1 
ATOM 633  O O   . ALA A 1 115 ? 225.343 214.493 210.994 1.00 88.32  ? 155 ALA A O   1 
ATOM 634  C CB  . ALA A 1 115 ? 223.491 212.328 209.830 1.00 84.47  ? 155 ALA A CB  1 
ATOM 635  N N   . SER A 1 116 ? 223.722 215.699 209.975 1.00 75.22  ? 156 SER A N   1 
ATOM 636  C CA  . SER A 1 116 ? 223.807 216.858 210.864 1.00 80.20  ? 156 SER A CA  1 
ATOM 637  C C   . SER A 1 116 ? 225.212 217.447 210.911 1.00 81.13  ? 156 SER A C   1 
ATOM 638  O O   . SER A 1 116 ? 225.630 217.998 211.932 1.00 86.50  ? 156 SER A O   1 
ATOM 639  C CB  . SER A 1 116 ? 223.327 216.514 212.276 1.00 85.61  ? 156 SER A CB  1 
ATOM 640  O OG  . SER A 1 116 ? 221.913 216.483 212.336 1.00 88.04  ? 156 SER A OG  1 
ATOM 641  N N   . MET A 1 117 ? 225.954 217.340 209.815 1.00 79.10  ? 157 MET A N   1 
ATOM 642  C CA  . MET A 1 117 ? 227.226 218.034 209.727 1.00 81.72  ? 157 MET A CA  1 
ATOM 643  C C   . MET A 1 117 ? 226.984 219.512 209.443 1.00 82.92  ? 157 MET A C   1 
ATOM 644  O O   . MET A 1 117 ? 225.868 219.938 209.138 1.00 86.20  ? 157 MET A O   1 
ATOM 645  C CB  . MET A 1 117 ? 228.112 217.403 208.653 1.00 80.15  ? 157 MET A CB  1 
ATOM 646  C CG  . MET A 1 117 ? 228.054 218.079 207.297 1.00 79.02  ? 157 MET A CG  1 
ATOM 647  S SD  . MET A 1 117 ? 226.457 217.893 206.497 1.00 78.91  ? 157 MET A SD  1 
ATOM 648  C CE  . MET A 1 117 ? 226.465 216.138 206.182 1.00 81.56  ? 157 MET A CE  1 
ATOM 649  N N   . SER A 1 118 ? 228.040 220.309 209.564 1.00 80.30  ? 158 SER A N   1 
ATOM 650  C CA  . SER A 1 118 ? 227.957 221.739 209.313 1.00 79.45  ? 158 SER A CA  1 
ATOM 651  C C   . SER A 1 118 ? 228.819 222.085 208.109 1.00 82.85  ? 158 SER A C   1 
ATOM 652  O O   . SER A 1 118 ? 229.968 221.642 208.016 1.00 86.33  ? 158 SER A O   1 
ATOM 653  C CB  . SER A 1 118 ? 228.388 222.530 210.543 1.00 83.21  ? 158 SER A CB  1 
ATOM 654  O OG  . SER A 1 118 ? 227.631 222.152 211.677 1.00 88.19  ? 158 SER A OG  1 
ATOM 655  N N   . LEU A 1 119 ? 228.262 222.865 207.188 1.00 83.79  ? 159 LEU A N   1 
ATOM 656  C CA  . LEU A 1 119 ? 228.909 223.166 205.920 1.00 82.00  ? 159 LEU A CA  1 
ATOM 657  C C   . LEU A 1 119 ? 228.772 224.647 205.602 1.00 81.93  ? 159 LEU A C   1 
ATOM 658  O O   . LEU A 1 119 ? 227.693 225.226 205.753 1.00 84.04  ? 159 LEU A O   1 
ATOM 659  C CB  . LEU A 1 119 ? 228.305 222.327 204.788 1.00 76.76  ? 159 LEU A CB  1 
ATOM 660  C CG  . LEU A 1 119 ? 228.486 222.839 203.360 1.00 75.28  ? 159 LEU A CG  1 
ATOM 661  C CD1 . LEU A 1 119 ? 229.928 222.680 202.926 1.00 83.48  ? 159 LEU A CD1 1 
ATOM 662  C CD2 . LEU A 1 119 ? 227.558 222.106 202.411 1.00 77.86  ? 159 LEU A CD2 1 
ATOM 663  N N   . VAL A 1 120 ? 229.874 225.255 205.162 1.00 84.48  ? 160 VAL A N   1 
ATOM 664  C CA  . VAL A 1 120 ? 229.884 226.645 204.730 1.00 86.09  ? 160 VAL A CA  1 
ATOM 665  C C   . VAL A 1 120 ? 230.667 226.750 203.430 1.00 87.91  ? 160 VAL A C   1 
ATOM 666  O O   . VAL A 1 120 ? 231.404 225.841 203.045 1.00 87.14  ? 160 VAL A O   1 
ATOM 667  C CB  . VAL A 1 120 ? 230.481 227.592 205.791 1.00 82.62  ? 160 VAL A CB  1 
ATOM 668  C CG1 . VAL A 1 120 ? 229.476 227.843 206.901 1.00 85.78  ? 160 VAL A CG1 1 
ATOM 669  C CG2 . VAL A 1 120 ? 231.767 227.016 206.348 1.00 84.69  ? 160 VAL A CG2 1 
ATOM 670  N N   . LEU A 1 121 ? 230.493 227.879 202.748 1.00 90.93  ? 161 LEU A N   1 
ATOM 671  C CA  . LEU A 1 121 ? 231.192 228.158 201.501 1.00 92.70  ? 161 LEU A CA  1 
ATOM 672  C C   . LEU A 1 121 ? 232.051 229.400 201.673 1.00 96.49  ? 161 LEU A C   1 
ATOM 673  O O   . LEU A 1 121 ? 231.549 230.460 202.060 1.00 99.85  ? 161 LEU A O   1 
ATOM 674  C CB  . LEU A 1 121 ? 230.210 228.351 200.345 1.00 91.93  ? 161 LEU A CB  1 
ATOM 675  C CG  . LEU A 1 121 ? 230.830 228.585 198.968 1.00 93.14  ? 161 LEU A CG  1 
ATOM 676  C CD1 . LEU A 1 121 ? 230.999 227.270 198.229 1.00 94.80  ? 161 LEU A CD1 1 
ATOM 677  C CD2 . LEU A 1 121 ? 229.980 229.548 198.161 1.00 89.83  ? 161 LEU A CD2 1 
ATOM 678  N N   . HIS A 1 122 ? 233.340 229.265 201.381 1.00 97.67  ? 162 HIS A N   1 
ATOM 679  C CA  . HIS A 1 122 ? 234.298 230.361 201.462 1.00 100.54 ? 162 HIS A CA  1 
ATOM 680  C C   . HIS A 1 122 ? 234.978 230.484 200.106 1.00 105.97 ? 162 HIS A C   1 
ATOM 681  O O   . HIS A 1 122 ? 235.724 229.586 199.699 1.00 105.95 ? 162 HIS A O   1 
ATOM 682  C CB  . HIS A 1 122 ? 235.316 230.116 202.573 1.00 99.70  ? 162 HIS A CB  1 
ATOM 683  C CG  . HIS A 1 122 ? 236.312 231.220 202.734 1.00 104.97 ? 162 HIS A CG  1 
ATOM 684  N ND1 . HIS A 1 122 ? 237.530 231.037 203.354 1.00 107.96 ? 162 HIS A ND1 1 
ATOM 685  C CD2 . HIS A 1 122 ? 236.272 232.520 202.360 1.00 107.60 ? 162 HIS A CD2 1 
ATOM 686  C CE1 . HIS A 1 122 ? 238.196 232.178 203.353 1.00 114.61 ? 162 HIS A CE1 1 
ATOM 687  N NE2 . HIS A 1 122 ? 237.455 233.093 202.756 1.00 111.51 ? 162 HIS A NE2 1 
ATOM 688  N N   . GLY A 1 123 ? 234.720 231.588 199.411 1.00 105.95 ? 163 GLY A N   1 
ATOM 689  C CA  . GLY A 1 123 ? 235.249 231.768 198.075 1.00 105.70 ? 163 GLY A CA  1 
ATOM 690  C C   . GLY A 1 123 ? 234.757 230.698 197.125 1.00 103.83 ? 163 GLY A C   1 
ATOM 691  O O   . GLY A 1 123 ? 233.582 230.682 196.749 1.00 102.83 ? 163 GLY A O   1 
ATOM 692  N N   . ASN A 1 124 ? 235.651 229.794 196.733 1.00 99.38  ? 164 ASN A N   1 
ATOM 693  C CA  . ASN A 1 124 ? 235.307 228.662 195.885 1.00 99.18  ? 164 ASN A CA  1 
ATOM 694  C C   . ASN A 1 124 ? 235.594 227.341 196.588 1.00 103.73 ? 164 ASN A C   1 
ATOM 695  O O   . ASN A 1 124 ? 235.951 226.351 195.946 1.00 108.11 ? 164 ASN A O   1 
ATOM 696  C CB  . ASN A 1 124 ? 236.054 228.734 194.555 1.00 102.48 ? 164 ASN A CB  1 
ATOM 697  C CG  . ASN A 1 124 ? 235.147 229.091 193.398 1.00 106.99 ? 164 ASN A CG  1 
ATOM 698  O OD1 . ASN A 1 124 ? 233.991 229.464 193.594 1.00 107.61 ? 164 ASN A OD1 1 
ATOM 699  N ND2 . ASN A 1 124 ? 235.666 228.978 192.182 1.00 109.02 ? 164 ASN A ND2 1 
ATOM 700  N N   . ASN A 1 125 ? 235.444 227.313 197.910 1.00 99.93  ? 165 ASN A N   1 
ATOM 701  C CA  . ASN A 1 125 ? 235.733 226.128 198.701 1.00 97.33  ? 165 ASN A CA  1 
ATOM 702  C C   . ASN A 1 125 ? 234.573 225.831 199.638 1.00 94.60  ? 165 ASN A C   1 
ATOM 703  O O   . ASN A 1 125 ? 233.868 226.736 200.089 1.00 93.37  ? 165 ASN A O   1 
ATOM 704  C CB  . ASN A 1 125 ? 237.020 226.299 199.511 1.00 94.80  ? 165 ASN A CB  1 
ATOM 705  C CG  . ASN A 1 125 ? 238.090 227.043 198.746 1.00 101.23 ? 165 ASN A CG  1 
ATOM 706  O OD1 . ASN A 1 125 ? 237.932 228.219 198.425 1.00 103.61 ? 165 ASN A OD1 1 
ATOM 707  N ND2 . ASN A 1 125 ? 239.186 226.359 198.445 1.00 102.82 ? 165 ASN A ND2 1 
ATOM 708  N N   . LEU A 1 126 ? 234.381 224.546 199.919 1.00 92.66  ? 166 LEU A N   1 
ATOM 709  C CA  . LEU A 1 126 ? 233.396 224.071 200.878 1.00 88.42  ? 166 LEU A CA  1 
ATOM 710  C C   . LEU A 1 126 ? 234.135 223.635 202.133 1.00 88.84  ? 166 LEU A C   1 
ATOM 711  O O   . LEU A 1 126 ? 235.014 222.770 202.066 1.00 92.45  ? 166 LEU A O   1 
ATOM 712  C CB  . LEU A 1 126 ? 232.590 222.904 200.311 1.00 88.99  ? 166 LEU A CB  1 
ATOM 713  C CG  . LEU A 1 126 ? 231.850 223.097 198.989 1.00 87.62  ? 166 LEU A CG  1 
ATOM 714  C CD1 . LEU A 1 126 ? 231.825 221.789 198.222 1.00 81.64  ? 166 LEU A CD1 1 
ATOM 715  C CD2 . LEU A 1 126 ? 230.441 223.600 199.232 1.00 84.06  ? 166 LEU A CD2 1 
ATOM 716  N N   . LEU A 1 127 ? 233.781 224.233 203.265 1.00 85.66  ? 167 LEU A N   1 
ATOM 717  C CA  . LEU A 1 127 ? 234.342 223.870 204.558 1.00 84.80  ? 167 LEU A CA  1 
ATOM 718  C C   . LEU A 1 127 ? 233.312 223.043 205.314 1.00 86.84  ? 167 LEU A C   1 
ATOM 719  O O   . LEU A 1 127 ? 232.182 223.496 205.529 1.00 86.91  ? 167 LEU A O   1 
ATOM 720  C CB  . LEU A 1 127 ? 234.726 225.115 205.356 1.00 82.86  ? 167 LEU A CB  1 
ATOM 721  C CG  . LEU A 1 127 ? 236.020 225.817 204.948 1.00 86.90  ? 167 LEU A CG  1 
ATOM 722  C CD1 . LEU A 1 127 ? 235.821 227.320 204.926 1.00 89.43  ? 167 LEU A CD1 1 
ATOM 723  C CD2 . LEU A 1 127 ? 237.145 225.443 205.893 1.00 94.87  ? 167 LEU A CD2 1 
ATOM 724  N N   . VAL A 1 128 ? 233.704 221.836 205.714 1.00 85.83  ? 168 VAL A N   1 
ATOM 725  C CA  . VAL A 1 128 ? 232.830 220.895 206.399 1.00 83.64  ? 168 VAL A CA  1 
ATOM 726  C C   . VAL A 1 128 ? 233.424 220.608 207.769 1.00 86.77  ? 168 VAL A C   1 
ATOM 727  O O   . VAL A 1 128 ? 234.609 220.272 207.880 1.00 91.35  ? 168 VAL A O   1 
ATOM 728  C CB  . VAL A 1 128 ? 232.660 219.593 205.596 1.00 84.80  ? 168 VAL A CB  1 
ATOM 729  C CG1 . VAL A 1 128 ? 232.108 218.490 206.480 1.00 88.56  ? 168 VAL A CG1 1 
ATOM 730  C CG2 . VAL A 1 128 ? 231.756 219.826 204.401 1.00 83.76  ? 168 VAL A CG2 1 
ATOM 731  N N   . PHE A 1 129 ? 232.602 220.746 208.807 1.00 87.40  ? 169 PHE A N   1 
ATOM 732  C CA  . PHE A 1 129 ? 233.025 220.495 210.174 1.00 90.29  ? 169 PHE A CA  1 
ATOM 733  C C   . PHE A 1 129 ? 231.909 219.788 210.927 1.00 90.92  ? 169 PHE A C   1 
ATOM 734  O O   . PHE A 1 129 ? 230.723 220.014 210.669 1.00 93.30  ? 169 PHE A O   1 
ATOM 735  C CB  . PHE A 1 129 ? 233.403 221.797 210.892 1.00 89.78  ? 169 PHE A CB  1 
ATOM 736  C CG  . PHE A 1 129 ? 233.663 221.626 212.358 1.00 89.96  ? 169 PHE A CG  1 
ATOM 737  C CD1 . PHE A 1 129 ? 234.874 221.135 212.804 1.00 90.15  ? 169 PHE A CD1 1 
ATOM 738  C CD2 . PHE A 1 129 ? 232.694 221.950 213.290 1.00 90.72  ? 169 PHE A CD2 1 
ATOM 739  C CE1 . PHE A 1 129 ? 235.116 220.973 214.149 1.00 94.44  ? 169 PHE A CE1 1 
ATOM 740  C CE2 . PHE A 1 129 ? 232.931 221.787 214.636 1.00 91.35  ? 169 PHE A CE2 1 
ATOM 741  C CZ  . PHE A 1 129 ? 234.143 221.299 215.066 1.00 95.78  ? 169 PHE A CZ  1 
ATOM 742  N N   . GLY A 1 130 ? 232.302 218.928 211.860 1.00 87.61  ? 170 GLY A N   1 
ATOM 743  C CA  . GLY A 1 130 ? 231.348 218.259 212.716 1.00 87.09  ? 170 GLY A CA  1 
ATOM 744  C C   . GLY A 1 130 ? 230.554 217.189 211.987 1.00 84.75  ? 170 GLY A C   1 
ATOM 745  O O   . GLY A 1 130 ? 230.886 216.751 210.887 1.00 88.71  ? 170 GLY A O   1 
ATOM 746  N N   . GLY A 1 131 ? 229.475 216.772 212.638 1.00 82.14  ? 171 GLY A N   1 
ATOM 747  C CA  . GLY A 1 131 ? 228.591 215.759 212.105 1.00 84.28  ? 171 GLY A CA  1 
ATOM 748  C C   . GLY A 1 131 ? 228.777 214.417 212.786 1.00 90.42  ? 171 GLY A C   1 
ATOM 749  O O   . GLY A 1 131 ? 229.720 214.184 213.545 1.00 95.84  ? 171 GLY A O   1 
ATOM 750  N N   . THR A 1 132 ? 227.842 213.515 212.499 1.00 90.56  ? 172 THR A N   1 
ATOM 751  C CA  . THR A 1 132 ? 227.857 212.181 213.074 1.00 92.75  ? 172 THR A CA  1 
ATOM 752  C C   . THR A 1 132 ? 227.567 211.155 211.990 1.00 93.11  ? 172 THR A C   1 
ATOM 753  O O   . THR A 1 132 ? 226.926 211.458 210.981 1.00 91.89  ? 172 THR A O   1 
ATOM 754  C CB  . THR A 1 132 ? 226.830 212.036 214.202 1.00 94.10  ? 172 THR A CB  1 
ATOM 755  O OG1 . THR A 1 132 ? 226.768 210.666 214.617 1.00 99.86  ? 172 THR A OG1 1 
ATOM 756  C CG2 . THR A 1 132 ? 225.458 212.472 213.726 1.00 91.54  ? 172 THR A CG2 1 
ATOM 757  N N   . GLY A 1 133 ? 228.051 209.937 212.209 1.00 97.06  ? 173 GLY A N   1 
ATOM 758  C CA  . GLY A 1 133 ? 227.758 208.839 211.311 1.00 99.89  ? 173 GLY A CA  1 
ATOM 759  C C   . GLY A 1 133 ? 226.474 208.142 211.702 1.00 102.39 ? 173 GLY A C   1 
ATOM 760  O O   . GLY A 1 133 ? 225.508 208.798 212.103 1.00 105.01 ? 173 GLY A O   1 
ATOM 761  N N   . ILE A 1 134 ? 226.442 206.819 211.591 1.00 103.67 ? 174 ILE A N   1 
ATOM 762  C CA  . ILE A 1 134 ? 225.287 206.049 212.044 1.00 105.00 ? 174 ILE A CA  1 
ATOM 763  C C   . ILE A 1 134 ? 225.802 204.853 212.840 1.00 111.42 ? 174 ILE A C   1 
ATOM 764  O O   . ILE A 1 134 ? 226.816 204.247 212.460 1.00 114.47 ? 174 ILE A O   1 
ATOM 765  C CB  . ILE A 1 134 ? 224.389 205.642 210.860 1.00 101.88 ? 174 ILE A CB  1 
ATOM 766  C CG1 . ILE A 1 134 ? 222.921 205.613 211.287 1.00 103.00 ? 174 ILE A CG1 1 
ATOM 767  C CG2 . ILE A 1 134 ? 224.799 204.301 210.264 1.00 104.17 ? 174 ILE A CG2 1 
ATOM 768  C CD1 . ILE A 1 134 ? 222.310 206.985 211.442 1.00 98.80  ? 174 ILE A CD1 1 
ATOM 769  N N   . PRO A 1 135 ? 225.188 204.514 213.982 1.00 113.12 ? 175 PRO A N   1 
ATOM 770  C CA  . PRO A 1 135 ? 224.059 205.184 214.645 1.00 114.38 ? 175 PRO A CA  1 
ATOM 771  C C   . PRO A 1 135 ? 224.457 206.537 215.226 1.00 114.35 ? 175 PRO A C   1 
ATOM 772  O O   . PRO A 1 135 ? 225.641 206.819 215.380 1.00 117.46 ? 175 PRO A O   1 
ATOM 773  C CB  . PRO A 1 135 ? 223.663 204.182 215.735 1.00 116.95 ? 175 PRO A CB  1 
ATOM 774  C CG  . PRO A 1 135 ? 224.951 203.503 216.083 1.00 118.19 ? 175 PRO A CG  1 
ATOM 775  C CD  . PRO A 1 135 ? 225.678 203.370 214.771 1.00 112.41 ? 175 PRO A CD  1 
ATOM 776  N N   . PHE A 1 136 ? 223.483 207.388 215.541 1.00 111.19 ? 176 PHE A N   1 
ATOM 777  C CA  . PHE A 1 136 ? 223.780 208.743 215.989 1.00 107.56 ? 176 PHE A CA  1 
ATOM 778  C C   . PHE A 1 136 ? 224.583 208.726 217.283 1.00 110.02 ? 176 PHE A C   1 
ATOM 779  O O   . PHE A 1 136 ? 224.242 208.016 218.233 1.00 119.90 ? 176 PHE A O   1 
ATOM 780  C CB  . PHE A 1 136 ? 222.483 209.523 216.184 1.00 104.84 ? 176 PHE A CB  1 
ATOM 781  C CG  . PHE A 1 136 ? 221.644 209.618 214.946 1.00 103.89 ? 176 PHE A CG  1 
ATOM 782  C CD1 . PHE A 1 136 ? 222.168 210.145 213.779 1.00 101.48 ? 176 PHE A CD1 1 
ATOM 783  C CD2 . PHE A 1 136 ? 220.333 209.179 214.947 1.00 101.02 ? 176 PHE A CD2 1 
ATOM 784  C CE1 . PHE A 1 136 ? 221.399 210.235 212.638 1.00 96.32  ? 176 PHE A CE1 1 
ATOM 785  C CE2 . PHE A 1 136 ? 219.559 209.267 213.809 1.00 97.07  ? 176 PHE A CE2 1 
ATOM 786  C CZ  . PHE A 1 136 ? 220.093 209.795 212.653 1.00 95.56  ? 176 PHE A CZ  1 
ATOM 787  N N   . GLY A 1 137 ? 225.656 209.515 217.314 1.00 104.02 ? 177 GLY A N   1 
ATOM 788  C CA  . GLY A 1 137 ? 226.506 209.614 218.478 1.00 105.12 ? 177 GLY A CA  1 
ATOM 789  C C   . GLY A 1 137 ? 227.578 208.555 218.586 1.00 106.87 ? 177 GLY A C   1 
ATOM 790  O O   . GLY A 1 137 ? 228.426 208.647 219.482 1.00 108.88 ? 177 GLY A O   1 
ATOM 791  N N   . GLU A 1 138 ? 227.576 207.551 217.707 1.00 109.07 ? 178 GLU A N   1 
ATOM 792  C CA  . GLU A 1 138 ? 228.587 206.502 217.782 1.00 113.63 ? 178 GLU A CA  1 
ATOM 793  C C   . GLU A 1 138 ? 229.956 207.020 217.359 1.00 117.19 ? 178 GLU A C   1 
ATOM 794  O O   . GLU A 1 138 ? 230.971 206.683 217.978 1.00 118.18 ? 178 GLU A O   1 
ATOM 795  C CB  . GLU A 1 138 ? 228.174 205.311 216.919 1.00 108.63 ? 178 GLU A CB  1 
ATOM 796  N N   . SER A 1 139 ? 230.005 207.839 216.308 1.00 115.13 ? 179 SER A N   1 
ATOM 797  C CA  . SER A 1 139 ? 231.274 208.359 215.801 1.00 111.34 ? 179 SER A CA  1 
ATOM 798  C C   . SER A 1 139 ? 231.017 209.760 215.254 1.00 107.25 ? 179 SER A C   1 
ATOM 799  O O   . SER A 1 139 ? 230.542 209.909 214.125 1.00 108.06 ? 179 SER A O   1 
ATOM 800  C CB  . SER A 1 139 ? 231.856 207.441 214.735 1.00 115.00 ? 179 SER A CB  1 
ATOM 801  O OG  . SER A 1 139 ? 233.157 207.858 214.361 1.00 120.65 ? 179 SER A OG  1 
ATOM 802  N N   . ASN A 1 140 ? 231.336 210.771 216.053 1.00 104.93 ? 180 ASN A N   1 
ATOM 803  C CA  . ASN A 1 140 ? 231.186 212.155 215.636 1.00 103.06 ? 180 ASN A CA  1 
ATOM 804  C C   . ASN A 1 140 ? 232.501 212.685 215.074 1.00 104.39 ? 180 ASN A C   1 
ATOM 805  O O   . ASN A 1 140 ? 233.551 212.045 215.162 1.00 108.70 ? 180 ASN A O   1 
ATOM 806  C CB  . ASN A 1 140 ? 230.716 213.016 216.806 1.00 100.71 ? 180 ASN A CB  1 
ATOM 807  C CG  . ASN A 1 140 ? 229.570 212.387 217.565 1.00 104.76 ? 180 ASN A CG  1 
ATOM 808  O OD1 . ASN A 1 140 ? 229.560 211.182 217.809 1.00 109.11 ? 180 ASN A OD1 1 
ATOM 809  N ND2 . ASN A 1 140 ? 228.599 213.203 217.952 1.00 102.86 ? 180 ASN A ND2 1 
ATOM 810  N N   . GLY A 1 141 ? 232.435 213.875 214.487 1.00 100.31 ? 181 GLY A N   1 
ATOM 811  C CA  . GLY A 1 141 ? 233.591 214.501 213.880 1.00 100.17 ? 181 GLY A CA  1 
ATOM 812  C C   . GLY A 1 141 ? 233.920 215.822 214.546 1.00 100.01 ? 181 GLY A C   1 
ATOM 813  O O   . GLY A 1 141 ? 233.030 216.557 214.976 1.00 99.63  ? 181 GLY A O   1 
ATOM 814  N N   . ASN A 1 142 ? 235.219 216.119 214.629 1.00 100.39 ? 182 ASN A N   1 
ATOM 815  C CA  . ASN A 1 142 ? 235.668 217.370 215.227 1.00 100.21 ? 182 ASN A CA  1 
ATOM 816  C C   . ASN A 1 142 ? 236.793 218.018 214.427 1.00 101.35 ? 182 ASN A C   1 
ATOM 817  O O   . ASN A 1 142 ? 237.466 218.919 214.942 1.00 103.43 ? 182 ASN A O   1 
ATOM 818  C CB  . ASN A 1 142 ? 236.124 217.151 216.671 1.00 104.07 ? 182 ASN A CB  1 
ATOM 819  C CG  . ASN A 1 142 ? 237.421 216.376 216.759 1.00 108.26 ? 182 ASN A CG  1 
ATOM 820  O OD1 . ASN A 1 142 ? 237.522 215.254 216.265 1.00 110.17 ? 182 ASN A OD1 1 
ATOM 821  N ND2 . ASN A 1 142 ? 238.422 216.972 217.393 1.00 105.70 ? 182 ASN A ND2 1 
ATOM 822  N N   . ASP A 1 143 ? 237.017 217.586 213.192 1.00 100.94 ? 183 ASP A N   1 
ATOM 823  C CA  . ASP A 1 143 ? 238.034 218.152 212.320 1.00 99.38  ? 183 ASP A CA  1 
ATOM 824  C C   . ASP A 1 143 ? 237.364 218.914 211.182 1.00 96.60  ? 183 ASP A C   1 
ATOM 825  O O   . ASP A 1 143 ? 236.137 218.957 211.066 1.00 97.76  ? 183 ASP A O   1 
ATOM 826  C CB  . ASP A 1 143 ? 238.954 217.055 211.784 1.00 105.27 ? 183 ASP A CB  1 
ATOM 827  C CG  . ASP A 1 143 ? 238.218 215.761 211.518 1.00 116.14 ? 183 ASP A CG  1 
ATOM 828  O OD1 . ASP A 1 143 ? 236.975 215.798 211.412 1.00 115.09 ? 183 ASP A OD1 1 
ATOM 829  O OD2 . ASP A 1 143 ? 238.880 214.708 211.417 1.00 123.46 ? 183 ASP A OD2 1 
ATOM 830  N N   . VAL A 1 144 ? 238.188 219.515 210.329 1.00 93.63  ? 184 VAL A N   1 
ATOM 831  C CA  . VAL A 1 144 ? 237.717 220.351 209.233 1.00 91.13  ? 184 VAL A CA  1 
ATOM 832  C C   . VAL A 1 144 ? 238.213 219.766 207.919 1.00 98.75  ? 184 VAL A C   1 
ATOM 833  O O   . VAL A 1 144 ? 239.413 219.514 207.757 1.00 104.19 ? 184 VAL A O   1 
ATOM 834  C CB  . VAL A 1 144 ? 238.185 221.809 209.391 1.00 85.37  ? 184 VAL A CB  1 
ATOM 835  C CG1 . VAL A 1 144 ? 238.009 222.566 208.089 1.00 85.97  ? 184 VAL A CG1 1 
ATOM 836  C CG2 . VAL A 1 144 ? 237.415 222.486 210.508 1.00 89.25  ? 184 VAL A CG2 1 
ATOM 837  N N   . HIS A 1 145 ? 237.289 219.545 206.990 1.00 96.40  ? 185 HIS A N   1 
ATOM 838  C CA  . HIS A 1 145 ? 237.615 219.142 205.633 1.00 93.65  ? 185 HIS A CA  1 
ATOM 839  C C   . HIS A 1 145 ? 237.285 220.278 204.677 1.00 92.64  ? 185 HIS A C   1 
ATOM 840  O O   . HIS A 1 145 ? 236.364 221.063 204.915 1.00 93.89  ? 185 HIS A O   1 
ATOM 841  C CB  . HIS A 1 145 ? 236.850 217.882 205.223 1.00 90.78  ? 185 HIS A CB  1 
ATOM 842  C CG  . HIS A 1 145 ? 236.994 216.746 206.184 1.00 93.43  ? 185 HIS A CG  1 
ATOM 843  N ND1 . HIS A 1 145 ? 236.155 216.574 207.263 1.00 97.94  ? 185 HIS A ND1 1 
ATOM 844  C CD2 . HIS A 1 145 ? 237.874 215.718 206.223 1.00 94.88  ? 185 HIS A CD2 1 
ATOM 845  C CE1 . HIS A 1 145 ? 236.514 215.491 207.928 1.00 101.15 ? 185 HIS A CE1 1 
ATOM 846  N NE2 . HIS A 1 145 ? 237.555 214.953 207.318 1.00 102.93 ? 185 HIS A NE2 1 
ATOM 847  N N   . VAL A 1 146 ? 238.051 220.370 203.597 1.00 90.96  ? 186 VAL A N   1 
ATOM 848  C CA  . VAL A 1 146 ? 237.848 221.393 202.582 1.00 90.39  ? 186 VAL A CA  1 
ATOM 849  C C   . VAL A 1 146 ? 237.756 220.711 201.225 1.00 94.55  ? 186 VAL A C   1 
ATOM 850  O O   . VAL A 1 146 ? 238.553 219.819 200.913 1.00 96.87  ? 186 VAL A O   1 
ATOM 851  C CB  . VAL A 1 146 ? 238.967 222.454 202.597 1.00 90.83  ? 186 VAL A CB  1 
ATOM 852  C CG1 . VAL A 1 146 ? 240.329 221.820 202.350 1.00 97.26  ? 186 VAL A CG1 1 
ATOM 853  C CG2 . VAL A 1 146 ? 238.682 223.541 201.577 1.00 94.03  ? 186 VAL A CG2 1 
ATOM 854  N N   . CYS A 1 147 ? 236.768 221.110 200.433 1.00 95.09  ? 187 CYS A N   1 
ATOM 855  C CA  . CYS A 1 147 ? 236.592 220.592 199.083 1.00 98.68  ? 187 CYS A CA  1 
ATOM 856  C C   . CYS A 1 147 ? 236.550 221.759 198.111 1.00 102.12 ? 187 CYS A C   1 
ATOM 857  O O   . CYS A 1 147 ? 235.706 222.648 198.239 1.00 99.72  ? 187 CYS A O   1 
ATOM 858  C CB  . CYS A 1 147 ? 235.319 219.754 198.970 1.00 99.10  ? 187 CYS A CB  1 
ATOM 859  S SG  . CYS A 1 147 ? 235.036 219.072 197.321 1.00 110.29 ? 187 CYS A SG  1 
ATOM 860  N N   . ASN A 1 148 ? 237.453 221.748 197.140 1.00 105.19 ? 188 ASN A N   1 
ATOM 861  C CA  . ASN A 1 148 ? 237.464 222.760 196.093 1.00 102.72 ? 188 ASN A CA  1 
ATOM 862  C C   . ASN A 1 148 ? 236.574 222.293 194.950 1.00 107.04 ? 188 ASN A C   1 
ATOM 863  O O   . ASN A 1 148 ? 236.811 221.228 194.364 1.00 113.64 ? 188 ASN A O   1 
ATOM 864  C CB  . ASN A 1 148 ? 238.882 223.029 195.599 1.00 103.49 ? 188 ASN A CB  1 
ATOM 865  C CG  . ASN A 1 148 ? 238.956 224.240 194.694 1.00 108.87 ? 188 ASN A CG  1 
ATOM 866  O OD1 . ASN A 1 148 ? 238.515 224.199 193.546 1.00 110.56 ? 188 ASN A OD1 1 
ATOM 867  N ND2 . ASN A 1 148 ? 239.510 225.330 195.208 1.00 111.39 ? 188 ASN A ND2 1 
ATOM 868  N N   . VAL A 1 149 ? 235.543 223.087 194.650 1.00 100.85 ? 189 VAL A N   1 
ATOM 869  C CA  . VAL A 1 149 ? 234.599 222.733 193.596 1.00 104.80 ? 189 VAL A CA  1 
ATOM 870  C C   . VAL A 1 149 ? 235.246 222.863 192.222 1.00 110.62 ? 189 VAL A C   1 
ATOM 871  O O   . VAL A 1 149 ? 235.055 222.008 191.350 1.00 111.90 ? 189 VAL A O   1 
ATOM 872  C CB  . VAL A 1 149 ? 233.324 223.588 193.713 1.00 99.65  ? 189 VAL A CB  1 
ATOM 873  C CG1 . VAL A 1 149 ? 232.534 223.177 194.936 1.00 96.39  ? 189 VAL A CG1 1 
ATOM 874  C CG2 . VAL A 1 149 ? 233.671 225.063 193.796 1.00 100.19 ? 189 VAL A CG2 1 
ATOM 875  N N   . LYS A 1 150 ? 236.011 223.935 192.001 1.00 112.50 ? 190 LYS A N   1 
ATOM 876  C CA  . LYS A 1 150 ? 236.684 224.107 190.718 1.00 113.96 ? 190 LYS A CA  1 
ATOM 877  C C   . LYS A 1 150 ? 237.692 222.991 190.482 1.00 116.26 ? 190 LYS A C   1 
ATOM 878  O O   . LYS A 1 150 ? 237.751 222.412 189.392 1.00 117.81 ? 190 LYS A O   1 
ATOM 879  C CB  . LYS A 1 150 ? 237.364 225.474 190.660 1.00 109.94 ? 190 LYS A CB  1 
ATOM 880  N N   . TYR A 1 151 ? 238.492 222.671 191.499 1.00 115.63 ? 191 TYR A N   1 
ATOM 881  C CA  . TYR A 1 151 ? 239.400 221.537 191.420 1.00 113.13 ? 191 TYR A CA  1 
ATOM 882  C C   . TYR A 1 151 ? 238.721 220.218 191.756 1.00 111.94 ? 191 TYR A C   1 
ATOM 883  O O   . TYR A 1 151 ? 239.283 219.160 191.450 1.00 113.29 ? 191 TYR A O   1 
ATOM 884  C CB  . TYR A 1 151 ? 240.593 221.752 192.354 1.00 112.99 ? 191 TYR A CB  1 
ATOM 885  C CG  . TYR A 1 151 ? 241.544 222.835 191.900 1.00 116.66 ? 191 TYR A CG  1 
ATOM 886  C CD1 . TYR A 1 151 ? 241.233 224.177 192.071 1.00 117.91 ? 191 TYR A CD1 1 
ATOM 887  C CD2 . TYR A 1 151 ? 242.755 222.517 191.302 1.00 119.47 ? 191 TYR A CD2 1 
ATOM 888  C CE1 . TYR A 1 151 ? 242.098 225.169 191.658 1.00 122.05 ? 191 TYR A CE1 1 
ATOM 889  C CE2 . TYR A 1 151 ? 243.628 223.503 190.886 1.00 125.97 ? 191 TYR A CE2 1 
ATOM 890  C CZ  . TYR A 1 151 ? 243.293 224.827 191.067 1.00 128.66 ? 191 TYR A CZ  1 
ATOM 891  O OH  . TYR A 1 151 ? 244.158 225.815 190.655 1.00 131.19 ? 191 TYR A OH  1 
ATOM 892  N N   . LYS A 1 152 ? 237.533 220.260 192.361 1.00 111.34 ? 192 LYS A N   1 
ATOM 893  C CA  . LYS A 1 152 ? 236.783 219.064 192.741 1.00 109.49 ? 192 LYS A CA  1 
ATOM 894  C C   . LYS A 1 152 ? 237.644 218.116 193.572 1.00 108.44 ? 192 LYS A C   1 
ATOM 895  O O   . LYS A 1 152 ? 237.724 216.915 193.310 1.00 108.47 ? 192 LYS A O   1 
ATOM 896  C CB  . LYS A 1 152 ? 236.223 218.355 191.508 1.00 108.88 ? 192 LYS A CB  1 
ATOM 897  C CG  . LYS A 1 152 ? 234.772 218.680 191.208 1.00 104.00 ? 192 LYS A CG  1 
ATOM 898  C CD  . LYS A 1 152 ? 234.384 218.216 189.814 1.00 102.50 ? 192 LYS A CD  1 
ATOM 899  C CE  . LYS A 1 152 ? 232.949 218.590 189.487 1.00 105.86 ? 192 LYS A CE  1 
ATOM 900  N NZ  . LYS A 1 152 ? 232.774 220.062 189.362 1.00 113.26 ? 192 LYS A NZ  1 
ATOM 901  N N   . ARG A 1 153 ? 238.299 218.670 194.589 1.00 108.41 ? 193 ARG A N   1 
ATOM 902  C CA  . ARG A 1 153 ? 239.248 217.908 195.389 1.00 105.20 ? 193 ARG A CA  1 
ATOM 903  C C   . ARG A 1 153 ? 238.906 218.019 196.866 1.00 104.25 ? 193 ARG A C   1 
ATOM 904  O O   . ARG A 1 153 ? 238.312 219.003 197.307 1.00 104.78 ? 193 ARG A O   1 
ATOM 905  C CB  . ARG A 1 153 ? 240.687 218.385 195.155 1.00 100.72 ? 193 ARG A CB  1 
ATOM 906  N N   . TRP A 1 154 ? 239.294 216.997 197.627 1.00 103.96 ? 194 TRP A N   1 
ATOM 907  C CA  . TRP A 1 154 ? 239.081 216.943 199.066 1.00 100.61 ? 194 TRP A CA  1 
ATOM 908  C C   . TRP A 1 154 ? 240.416 216.974 199.799 1.00 99.75  ? 194 TRP A C   1 
ATOM 909  O O   . TRP A 1 154 ? 241.420 216.441 199.318 1.00 102.67 ? 194 TRP A O   1 
ATOM 910  C CB  . TRP A 1 154 ? 238.312 215.681 199.469 1.00 99.37  ? 194 TRP A CB  1 
ATOM 911  C CG  . TRP A 1 154 ? 236.830 215.774 199.290 1.00 97.49  ? 194 TRP A CG  1 
ATOM 912  C CD1 . TRP A 1 154 ? 236.096 215.241 198.275 1.00 100.60 ? 194 TRP A CD1 1 
ATOM 913  C CD2 . TRP A 1 154 ? 235.898 216.423 200.161 1.00 92.20  ? 194 TRP A CD2 1 
ATOM 914  N NE1 . TRP A 1 154 ? 234.765 215.525 198.453 1.00 92.93  ? 194 TRP A NE1 1 
ATOM 915  C CE2 . TRP A 1 154 ? 234.617 216.251 199.605 1.00 87.14  ? 194 TRP A CE2 1 
ATOM 916  C CE3 . TRP A 1 154 ? 236.023 217.137 201.355 1.00 94.69  ? 194 TRP A CE3 1 
ATOM 917  C CZ2 . TRP A 1 154 ? 233.470 216.765 200.199 1.00 88.57  ? 194 TRP A CZ2 1 
ATOM 918  C CZ3 . TRP A 1 154 ? 234.882 217.647 201.943 1.00 94.63  ? 194 TRP A CZ3 1 
ATOM 919  C CH2 . TRP A 1 154 ? 233.623 217.459 201.365 1.00 92.01  ? 194 TRP A CH2 1 
ATOM 920  N N   . ALA A 1 155 ? 240.416 217.603 200.971 1.00 99.00  ? 195 ALA A N   1 
ATOM 921  C CA  . ALA A 1 155 ? 241.607 217.675 201.806 1.00 102.28 ? 195 ALA A CA  1 
ATOM 922  C C   . ALA A 1 155 ? 241.169 217.924 203.242 1.00 105.78 ? 195 ALA A C   1 
ATOM 923  O O   . ALA A 1 155 ? 240.018 218.270 203.507 1.00 104.70 ? 195 ALA A O   1 
ATOM 924  C CB  . ALA A 1 155 ? 242.567 218.766 201.325 1.00 102.54 ? 195 ALA A CB  1 
ATOM 925  N N   . LEU A 1 156 ? 242.107 217.745 204.169 1.00 106.11 ? 196 LEU A N   1 
ATOM 926  C CA  . LEU A 1 156 ? 241.854 217.929 205.592 1.00 104.01 ? 196 LEU A CA  1 
ATOM 927  C C   . LEU A 1 156 ? 242.747 219.038 206.127 1.00 108.10 ? 196 LEU A C   1 
ATOM 928  O O   . LEU A 1 156 ? 243.950 219.058 205.849 1.00 110.38 ? 196 LEU A O   1 
ATOM 929  C CB  . LEU A 1 156 ? 242.101 216.632 206.365 1.00 101.82 ? 196 LEU A CB  1 
ATOM 930  C CG  . LEU A 1 156 ? 241.785 216.659 207.861 1.00 102.18 ? 196 LEU A CG  1 
ATOM 931  C CD1 . LEU A 1 156 ? 240.785 215.576 208.216 1.00 104.74 ? 196 LEU A CD1 1 
ATOM 932  C CD2 . LEU A 1 156 ? 243.055 216.495 208.673 1.00 106.56 ? 196 LEU A CD2 1 
ATOM 933  N N   . LEU A 1 157 ? 242.160 219.960 206.887 1.00 109.14 ? 197 LEU A N   1 
ATOM 934  C CA  . LEU A 1 157 ? 242.941 221.031 207.489 1.00 111.08 ? 197 LEU A CA  1 
ATOM 935  C C   . LEU A 1 157 ? 243.787 220.493 208.636 1.00 115.36 ? 197 LEU A C   1 
ATOM 936  O O   . LEU A 1 157 ? 243.360 219.614 209.388 1.00 117.07 ? 197 LEU A O   1 
ATOM 937  C CB  . LEU A 1 157 ? 242.026 222.147 207.994 1.00 106.16 ? 197 LEU A CB  1 
ATOM 938  C CG  . LEU A 1 157 ? 241.651 223.267 207.020 1.00 102.74 ? 197 LEU A CG  1 
ATOM 939  C CD1 . LEU A 1 157 ? 242.883 224.055 206.610 1.00 109.81 ? 197 LEU A CD1 1 
ATOM 940  C CD2 . LEU A 1 157 ? 240.928 222.731 205.800 1.00 99.22  ? 197 LEU A CD2 1 
ATOM 941  N N   . SER A 1 158 ? 244.992 221.040 208.774 1.00 116.48 ? 198 SER A N   1 
ATOM 942  C CA  . SER A 1 158 ? 245.944 220.630 209.803 1.00 116.79 ? 198 SER A CA  1 
ATOM 943  C C   . SER A 1 158 ? 245.923 221.573 210.997 1.00 117.25 ? 198 SER A C   1 
ATOM 944  O O   . SER A 1 158 ? 246.967 221.875 211.581 1.00 117.40 ? 198 SER A O   1 
ATOM 945  C CB  . SER A 1 158 ? 247.348 220.539 209.216 1.00 120.71 ? 198 SER A CB  1 
ATOM 946  O OG  . SER A 1 158 ? 247.648 221.689 208.444 1.00 123.98 ? 198 SER A OG  1 
ATOM 947  N N   . CYS A 1 159 ? 244.739 222.059 211.364 1.00 117.05 ? 199 CYS A N   1 
ATOM 948  C CA  . CYS A 1 159 ? 244.618 223.041 212.433 1.00 117.65 ? 199 CYS A CA  1 
ATOM 949  C C   . CYS A 1 159 ? 245.170 222.498 213.745 1.00 115.04 ? 199 CYS A C   1 
ATOM 950  O O   . CYS A 1 159 ? 244.995 221.323 214.076 1.00 116.46 ? 199 CYS A O   1 
ATOM 951  C CB  . CYS A 1 159 ? 243.154 223.444 212.612 1.00 116.91 ? 199 CYS A CB  1 
ATOM 952  S SG  . CYS A 1 159 ? 241.996 222.058 212.601 1.00 121.64 ? 199 CYS A SG  1 
ATOM 953  N N   . ARG A 1 160 ? 245.846 223.368 214.490 1.00 110.65 ? 200 ARG A N   1 
ATOM 954  C CA  . ARG A 1 160 ? 246.427 223.026 215.778 1.00 110.02 ? 200 ARG A CA  1 
ATOM 955  C C   . ARG A 1 160 ? 245.811 223.893 216.867 1.00 110.86 ? 200 ARG A C   1 
ATOM 956  O O   . ARG A 1 160 ? 245.337 225.003 216.607 1.00 110.03 ? 200 ARG A O   1 
ATOM 957  C CB  . ARG A 1 160 ? 247.949 223.205 215.768 1.00 105.31 ? 200 ARG A CB  1 
ATOM 958  N N   . GLY A 1 161 ? 245.820 223.373 218.092 1.00 112.78 ? 201 GLY A N   1 
ATOM 959  C CA  . GLY A 1 161 ? 245.249 224.035 219.241 1.00 111.04 ? 201 GLY A CA  1 
ATOM 960  C C   . GLY A 1 161 ? 244.246 223.131 219.919 1.00 109.88 ? 201 GLY A C   1 
ATOM 961  O O   . GLY A 1 161 ? 244.177 221.928 219.641 1.00 107.33 ? 201 GLY A O   1 
ATOM 962  N N   . LYS A 1 162 ? 243.459 223.712 220.819 1.00 108.44 ? 202 LYS A N   1 
ATOM 963  C CA  . LYS A 1 162 ? 242.419 222.971 221.521 1.00 109.74 ? 202 LYS A CA  1 
ATOM 964  C C   . LYS A 1 162 ? 241.138 222.996 220.693 1.00 108.17 ? 202 LYS A C   1 
ATOM 965  O O   . LYS A 1 162 ? 240.413 223.997 220.679 1.00 108.69 ? 202 LYS A O   1 
ATOM 966  C CB  . LYS A 1 162 ? 242.198 223.538 222.924 1.00 112.50 ? 202 LYS A CB  1 
ATOM 967  C CG  . LYS A 1 162 ? 241.970 225.041 222.999 1.00 110.59 ? 202 LYS A CG  1 
ATOM 968  C CD  . LYS A 1 162 ? 241.982 225.528 224.439 1.00 114.52 ? 202 LYS A CD  1 
ATOM 969  C CE  . LYS A 1 162 ? 241.093 224.668 225.323 1.00 114.06 ? 202 LYS A CE  1 
ATOM 970  N NZ  . LYS A 1 162 ? 239.693 224.609 224.819 1.00 112.07 ? 202 LYS A NZ  1 
ATOM 971  N N   . LYS A 1 163 ? 240.871 221.906 220.002 1.00 105.08 ? 203 LYS A N   1 
ATOM 972  C CA  . LYS A 1 163 ? 239.714 221.794 219.135 1.00 103.31 ? 203 LYS A CA  1 
ATOM 973  C C   . LYS A 1 163 ? 238.470 221.463 219.940 1.00 101.87 ? 203 LYS A C   1 
ATOM 974  O O   . LYS A 1 163 ? 238.556 220.922 221.046 1.00 102.98 ? 203 LYS A O   1 
ATOM 975  C CB  . LYS A 1 163 ? 239.950 220.711 218.074 1.00 105.50 ? 203 LYS A CB  1 
ATOM 976  C CG  . LYS A 1 163 ? 240.852 219.579 218.530 1.00 106.32 ? 203 LYS A CG  1 
ATOM 977  C CD  . LYS A 1 163 ? 241.249 218.684 217.368 1.00 100.06 ? 203 LYS A CD  1 
ATOM 978  C CE  . LYS A 1 163 ? 241.871 219.486 216.240 1.00 99.56  ? 203 LYS A CE  1 
ATOM 979  N NZ  . LYS A 1 163 ? 242.184 218.633 215.062 1.00 95.32  ? 203 LYS A NZ  1 
ATOM 980  N N   . PRO A 1 164 ? 237.288 221.792 219.421 1.00 99.04  ? 204 PRO A N   1 
ATOM 981  C CA  . PRO A 1 164 ? 236.054 221.367 220.088 1.00 102.41 ? 204 PRO A CA  1 
ATOM 982  C C   . PRO A 1 164 ? 235.935 219.852 220.094 1.00 105.94 ? 204 PRO A C   1 
ATOM 983  O O   . PRO A 1 164 ? 236.451 219.161 219.213 1.00 106.08 ? 204 PRO A O   1 
ATOM 984  C CB  . PRO A 1 164 ? 234.948 222.009 219.242 1.00 96.53  ? 204 PRO A CB  1 
ATOM 985  C CG  . PRO A 1 164 ? 235.615 223.075 218.459 1.00 95.51  ? 204 PRO A CG  1 
ATOM 986  C CD  . PRO A 1 164 ? 237.026 222.646 218.252 1.00 97.27  ? 204 PRO A CD  1 
ATOM 987  N N   . SER A 1 165 ? 235.251 219.336 221.109 1.00 105.39 ? 205 SER A N   1 
ATOM 988  C CA  . SER A 1 165 ? 235.021 217.904 221.194 1.00 104.58 ? 205 SER A CA  1 
ATOM 989  C C   . SER A 1 165 ? 234.135 217.440 220.041 1.00 101.56 ? 205 SER A C   1 
ATOM 990  O O   . SER A 1 165 ? 233.456 218.233 219.385 1.00 102.98 ? 205 SER A O   1 
ATOM 991  C CB  . SER A 1 165 ? 234.378 217.543 222.532 1.00 108.61 ? 205 SER A CB  1 
ATOM 992  O OG  . SER A 1 165 ? 233.286 218.400 222.817 1.00 111.98 ? 205 SER A OG  1 
ATOM 993  N N   . ARG A 1 166 ? 234.157 216.131 219.794 1.00 101.04 ? 206 ARG A N   1 
ATOM 994  C CA  . ARG A 1 166 ? 233.387 215.557 218.698 1.00 101.10 ? 206 ARG A CA  1 
ATOM 995  C C   . ARG A 1 166 ? 231.898 215.798 218.906 1.00 101.99 ? 206 ARG A C   1 
ATOM 996  O O   . ARG A 1 166 ? 231.288 215.219 219.809 1.00 105.06 ? 206 ARG A O   1 
ATOM 997  C CB  . ARG A 1 166 ? 233.678 214.062 218.568 1.00 100.32 ? 206 ARG A CB  1 
ATOM 998  C CG  . ARG A 1 166 ? 234.979 213.753 217.853 1.00 101.49 ? 206 ARG A CG  1 
ATOM 999  C CD  . ARG A 1 166 ? 235.402 212.313 218.071 1.00 105.04 ? 206 ARG A CD  1 
ATOM 1000 N NE  . ARG A 1 166 ? 236.089 211.767 216.908 1.00 116.35 ? 206 ARG A NE  1 
ATOM 1001 C CZ  . ARG A 1 166 ? 237.354 212.017 216.599 1.00 122.30 ? 206 ARG A CZ  1 
ATOM 1002 N NH1 . ARG A 1 166 ? 238.106 212.805 217.349 1.00 116.29 ? 206 ARG A NH1 1 
ATOM 1003 N NH2 . ARG A 1 166 ? 237.878 211.461 215.511 1.00 125.62 ? 206 ARG A NH2 1 
ATOM 1004 N N   . ILE A 1 167 ? 231.308 216.653 218.070 1.00 98.06  ? 207 ILE A N   1 
ATOM 1005 C CA  . ILE A 1 167 ? 229.927 217.084 218.227 1.00 92.44  ? 207 ILE A CA  1 
ATOM 1006 C C   . ILE A 1 167 ? 229.229 217.034 216.877 1.00 92.37  ? 207 ILE A C   1 
ATOM 1007 O O   . ILE A 1 167 ? 229.863 216.976 215.822 1.00 98.23  ? 207 ILE A O   1 
ATOM 1008 C CB  . ILE A 1 167 ? 229.827 218.504 218.817 1.00 91.54  ? 207 ILE A CB  1 
ATOM 1009 C CG1 . ILE A 1 167 ? 230.650 219.480 217.975 1.00 88.55  ? 207 ILE A CG1 1 
ATOM 1010 C CG2 . ILE A 1 167 ? 230.287 218.515 220.264 1.00 97.54  ? 207 ILE A CG2 1 
ATOM 1011 C CD1 . ILE A 1 167 ? 230.864 220.826 218.627 1.00 88.78  ? 207 ILE A CD1 1 
ATOM 1012 N N   . TYR A 1 168 ? 227.900 217.056 216.926 1.00 91.61  ? 208 TYR A N   1 
ATOM 1013 C CA  . TYR A 1 168 ? 227.082 217.183 215.731 1.00 90.27  ? 208 TYR A CA  1 
ATOM 1014 C C   . TYR A 1 168 ? 225.881 218.057 216.055 1.00 85.13  ? 208 TYR A C   1 
ATOM 1015 O O   . TYR A 1 168 ? 225.492 218.208 217.214 1.00 88.70  ? 208 TYR A O   1 
ATOM 1016 C CB  . TYR A 1 168 ? 226.630 215.819 215.192 1.00 91.32  ? 208 TYR A CB  1 
ATOM 1017 C CG  . TYR A 1 168 ? 225.523 215.159 215.980 1.00 91.70  ? 208 TYR A CG  1 
ATOM 1018 C CD1 . TYR A 1 168 ? 225.804 214.396 217.102 1.00 94.93  ? 208 TYR A CD1 1 
ATOM 1019 C CD2 . TYR A 1 168 ? 224.198 215.282 215.589 1.00 88.11  ? 208 TYR A CD2 1 
ATOM 1020 C CE1 . TYR A 1 168 ? 224.799 213.786 217.820 1.00 93.14  ? 208 TYR A CE1 1 
ATOM 1021 C CE2 . TYR A 1 168 ? 223.187 214.676 216.300 1.00 88.95  ? 208 TYR A CE2 1 
ATOM 1022 C CZ  . TYR A 1 168 ? 223.493 213.929 217.414 1.00 91.96  ? 208 TYR A CZ  1 
ATOM 1023 O OH  . TYR A 1 168 ? 222.488 213.322 218.126 1.00 96.57  ? 208 TYR A OH  1 
ATOM 1024 N N   . GLY A 1 169 ? 225.298 218.639 215.012 1.00 81.24  ? 209 GLY A N   1 
ATOM 1025 C CA  . GLY A 1 169 ? 224.215 219.578 215.188 1.00 85.18  ? 209 GLY A CA  1 
ATOM 1026 C C   . GLY A 1 169 ? 224.644 220.984 215.537 1.00 87.74  ? 209 GLY A C   1 
ATOM 1027 O O   . GLY A 1 169 ? 223.779 221.848 215.731 1.00 92.65  ? 209 GLY A O   1 
ATOM 1028 N N   . GLN A 1 170 ? 225.945 221.244 215.621 1.00 81.70  ? 210 GLN A N   1 
ATOM 1029 C CA  . GLN A 1 170 ? 226.445 222.570 215.942 1.00 77.84  ? 210 GLN A CA  1 
ATOM 1030 C C   . GLN A 1 170 ? 226.212 223.515 214.768 1.00 80.61  ? 210 GLN A C   1 
ATOM 1031 O O   . GLN A 1 170 ? 225.723 223.126 213.705 1.00 90.50  ? 210 GLN A O   1 
ATOM 1032 C CB  . GLN A 1 170 ? 227.927 222.495 216.295 1.00 83.17  ? 210 GLN A CB  1 
ATOM 1033 C CG  . GLN A 1 170 ? 228.853 222.450 215.088 1.00 82.76  ? 210 GLN A CG  1 
ATOM 1034 C CD  . GLN A 1 170 ? 228.762 221.150 214.311 1.00 82.46  ? 210 GLN A CD  1 
ATOM 1035 O OE1 . GLN A 1 170 ? 228.009 220.245 214.668 1.00 85.24  ? 210 GLN A OE1 1 
ATOM 1036 N NE2 . GLN A 1 170 ? 229.534 221.054 213.238 1.00 83.74  ? 210 GLN A NE2 1 
ATOM 1037 N N   . ALA A 1 171 ? 226.571 224.781 214.961 1.00 83.50  ? 211 ALA A N   1 
ATOM 1038 C CA  . ALA A 1 171 ? 226.436 225.780 213.911 1.00 83.73  ? 211 ALA A CA  1 
ATOM 1039 C C   . ALA A 1 171 ? 227.715 226.596 213.804 1.00 84.01  ? 211 ALA A C   1 
ATOM 1040 O O   . ALA A 1 171 ? 228.293 226.999 214.818 1.00 87.08  ? 211 ALA A O   1 
ATOM 1041 C CB  . ALA A 1 171 ? 225.243 226.697 214.171 1.00 85.41  ? 211 ALA A CB  1 
ATOM 1042 N N   . MET A 1 172 ? 228.148 226.844 212.570 1.00 80.25  ? 212 MET A N   1 
ATOM 1043 C CA  . MET A 1 172 ? 229.368 227.589 212.309 1.00 82.86  ? 212 MET A CA  1 
ATOM 1044 C C   . MET A 1 172 ? 229.071 228.832 211.483 1.00 86.21  ? 212 MET A C   1 
ATOM 1045 O O   . MET A 1 172 ? 228.023 228.954 210.845 1.00 88.34  ? 212 MET A O   1 
ATOM 1046 C CB  . MET A 1 172 ? 230.410 226.745 211.567 1.00 79.66  ? 212 MET A CB  1 
ATOM 1047 C CG  . MET A 1 172 ? 229.829 225.718 210.628 1.00 84.75  ? 212 MET A CG  1 
ATOM 1048 S SD  . MET A 1 172 ? 231.074 224.538 210.082 1.00 95.02  ? 212 MET A SD  1 
ATOM 1049 C CE  . MET A 1 172 ? 232.448 225.633 209.778 1.00 86.35  ? 212 MET A CE  1 
ATOM 1050 N N   . ALA A 1 173 ? 230.025 229.756 211.515 1.00 89.02  ? 213 ALA A N   1 
ATOM 1051 C CA  . ALA A 1 173 ? 229.974 230.964 210.709 1.00 90.74  ? 213 ALA A CA  1 
ATOM 1052 C C   . ALA A 1 173 ? 231.396 231.411 210.411 1.00 95.08  ? 213 ALA A C   1 
ATOM 1053 O O   . ALA A 1 173 ? 232.344 231.038 211.106 1.00 92.67  ? 213 ALA A O   1 
ATOM 1054 C CB  . ALA A 1 173 ? 229.193 232.082 211.408 1.00 94.88  ? 213 ALA A CB  1 
ATOM 1055 N N   . ILE A 1 174 ? 231.537 232.213 209.361 1.00 97.89  ? 214 ILE A N   1 
ATOM 1056 C CA  . ILE A 1 174 ? 232.822 232.771 208.961 1.00 97.80  ? 214 ILE A CA  1 
ATOM 1057 C C   . ILE A 1 174 ? 232.740 234.279 209.139 1.00 103.37 ? 214 ILE A C   1 
ATOM 1058 O O   . ILE A 1 174 ? 231.984 234.958 208.435 1.00 106.54 ? 214 ILE A O   1 
ATOM 1059 C CB  . ILE A 1 174 ? 233.186 232.400 207.518 1.00 93.42  ? 214 ILE A CB  1 
ATOM 1060 C CG1 . ILE A 1 174 ? 233.487 230.905 207.417 1.00 92.34  ? 214 ILE A CG1 1 
ATOM 1061 C CG2 . ILE A 1 174 ? 234.376 233.217 207.050 1.00 97.93  ? 214 ILE A CG2 1 
ATOM 1062 C CD1 . ILE A 1 174 ? 234.246 230.515 206.171 1.00 97.10  ? 214 ILE A CD1 1 
ATOM 1063 N N   . ILE A 1 175 ? 233.517 234.804 210.082 1.00 106.17 ? 215 ILE A N   1 
ATOM 1064 C CA  . ILE A 1 175 ? 233.541 236.229 210.386 1.00 107.86 ? 215 ILE A CA  1 
ATOM 1065 C C   . ILE A 1 175 ? 234.986 236.700 210.381 1.00 113.65 ? 215 ILE A C   1 
ATOM 1066 O O   . ILE A 1 175 ? 235.831 236.127 211.079 1.00 111.50 ? 215 ILE A O   1 
ATOM 1067 C CB  . ILE A 1 175 ? 232.881 236.537 211.743 1.00 103.27 ? 215 ILE A CB  1 
ATOM 1068 C CG1 . ILE A 1 175 ? 231.431 236.055 211.755 1.00 100.53 ? 215 ILE A CG1 1 
ATOM 1069 C CG2 . ILE A 1 175 ? 232.946 238.024 212.040 1.00 104.39 ? 215 ILE A CG2 1 
ATOM 1070 C CD1 . ILE A 1 175 ? 230.810 236.046 213.129 1.00 100.69 ? 215 ILE A CD1 1 
ATOM 1071 N N   . ASN A 1 176 ? 235.265 237.743 209.597 1.00 117.45 ? 216 ASN A N   1 
ATOM 1072 C CA  . ASN A 1 176 ? 236.591 238.361 209.538 1.00 117.23 ? 216 ASN A CA  1 
ATOM 1073 C C   . ASN A 1 176 ? 237.675 237.329 209.240 1.00 120.25 ? 216 ASN A C   1 
ATOM 1074 O O   . ASN A 1 176 ? 238.766 237.358 209.812 1.00 123.41 ? 216 ASN A O   1 
ATOM 1075 C CB  . ASN A 1 176 ? 236.900 239.117 210.831 1.00 113.96 ? 216 ASN A CB  1 
ATOM 1076 N N   . GLY A 1 177 ? 237.369 236.406 208.332 1.00 119.54 ? 217 GLY A N   1 
ATOM 1077 C CA  . GLY A 1 177 ? 238.314 235.358 207.990 1.00 119.83 ? 217 GLY A CA  1 
ATOM 1078 C C   . GLY A 1 177 ? 238.626 234.414 209.128 1.00 117.28 ? 217 GLY A C   1 
ATOM 1079 O O   . GLY A 1 177 ? 239.755 233.922 209.225 1.00 118.65 ? 217 GLY A O   1 
ATOM 1080 N N   . SER A 1 178 ? 237.654 234.147 209.997 1.00 110.87 ? 218 SER A N   1 
ATOM 1081 C CA  . SER A 1 178 ? 237.832 233.214 211.098 1.00 104.26 ? 218 SER A CA  1 
ATOM 1082 C C   . SER A 1 178 ? 236.564 232.394 211.266 1.00 100.34 ? 218 SER A C   1 
ATOM 1083 O O   . SER A 1 178 ? 235.470 232.831 210.902 1.00 101.43 ? 218 SER A O   1 
ATOM 1084 C CB  . SER A 1 178 ? 238.172 233.933 212.408 1.00 103.57 ? 218 SER A CB  1 
ATOM 1085 O OG  . SER A 1 178 ? 238.957 233.105 213.246 1.00 101.90 ? 218 SER A OG  1 
ATOM 1086 N N   . LEU A 1 179 ? 236.722 231.202 211.827 1.00 98.00  ? 219 LEU A N   1 
ATOM 1087 C CA  . LEU A 1 179 ? 235.637 230.239 211.960 1.00 91.90  ? 219 LEU A CA  1 
ATOM 1088 C C   . LEU A 1 179 ? 235.112 230.268 213.388 1.00 91.00  ? 219 LEU A C   1 
ATOM 1089 O O   . LEU A 1 179 ? 235.883 230.092 214.334 1.00 94.29  ? 219 LEU A O   1 
ATOM 1090 C CB  . LEU A 1 179 ? 236.130 228.839 211.601 1.00 91.70  ? 219 LEU A CB  1 
ATOM 1091 C CG  . LEU A 1 179 ? 235.152 227.868 210.952 1.00 91.66  ? 219 LEU A CG  1 
ATOM 1092 C CD1 . LEU A 1 179 ? 234.894 228.273 209.517 1.00 95.77  ? 219 LEU A CD1 1 
ATOM 1093 C CD2 . LEU A 1 179 ? 235.718 226.463 211.020 1.00 87.39  ? 219 LEU A CD2 1 
ATOM 1094 N N   . TYR A 1 180 ? 233.812 230.483 213.547 1.00 85.29  ? 220 TYR A N   1 
ATOM 1095 C CA  . TYR A 1 180 ? 233.172 230.459 214.855 1.00 85.10  ? 220 TYR A CA  1 
ATOM 1096 C C   . TYR A 1 180 ? 232.200 229.289 214.895 1.00 88.38  ? 220 TYR A C   1 
ATOM 1097 O O   . TYR A 1 180 ? 231.298 229.204 214.057 1.00 95.06  ? 220 TYR A O   1 
ATOM 1098 C CB  . TYR A 1 180 ? 232.449 231.774 215.137 1.00 84.45  ? 220 TYR A CB  1 
ATOM 1099 C CG  . TYR A 1 180 ? 233.380 232.936 215.398 1.00 91.17  ? 220 TYR A CG  1 
ATOM 1100 C CD1 . TYR A 1 180 ? 234.151 232.986 216.549 1.00 94.23  ? 220 TYR A CD1 1 
ATOM 1101 C CD2 . TYR A 1 180 ? 233.486 233.982 214.494 1.00 93.78  ? 220 TYR A CD2 1 
ATOM 1102 C CE1 . TYR A 1 180 ? 235.001 234.045 216.792 1.00 94.56  ? 220 TYR A CE1 1 
ATOM 1103 C CE2 . TYR A 1 180 ? 234.335 235.045 214.729 1.00 93.08  ? 220 TYR A CE2 1 
ATOM 1104 C CZ  . TYR A 1 180 ? 235.089 235.070 215.880 1.00 92.84  ? 220 TYR A CZ  1 
ATOM 1105 O OH  . TYR A 1 180 ? 235.937 236.126 216.121 1.00 91.92  ? 220 TYR A OH  1 
ATOM 1106 N N   . VAL A 1 181 ? 232.385 228.394 215.864 1.00 86.37  ? 221 VAL A N   1 
ATOM 1107 C CA  . VAL A 1 181 ? 231.586 227.181 215.991 1.00 81.15  ? 221 VAL A CA  1 
ATOM 1108 C C   . VAL A 1 181 ? 230.949 227.159 217.371 1.00 82.93  ? 221 VAL A C   1 
ATOM 1109 O O   . VAL A 1 181 ? 231.651 227.263 218.385 1.00 91.29  ? 221 VAL A O   1 
ATOM 1110 C CB  . VAL A 1 181 ? 232.435 225.917 215.770 1.00 78.17  ? 221 VAL A CB  1 
ATOM 1111 C CG1 . VAL A 1 181 ? 231.627 224.681 216.107 1.00 78.36  ? 221 VAL A CG1 1 
ATOM 1112 C CG2 . VAL A 1 181 ? 232.939 225.861 214.342 1.00 83.38  ? 221 VAL A CG2 1 
ATOM 1113 N N   . PHE A 1 182 ? 229.627 226.994 217.413 1.00 77.81  ? 222 PHE A N   1 
ATOM 1114 C CA  . PHE A 1 182 ? 228.885 227.020 218.663 1.00 80.89  ? 222 PHE A CA  1 
ATOM 1115 C C   . PHE A 1 182 ? 227.921 225.845 218.734 1.00 84.12  ? 222 PHE A C   1 
ATOM 1116 O O   . PHE A 1 182 ? 227.395 225.385 217.715 1.00 92.28  ? 222 PHE A O   1 
ATOM 1117 C CB  . PHE A 1 182 ? 228.103 228.330 218.822 1.00 81.42  ? 222 PHE A CB  1 
ATOM 1118 C CG  . PHE A 1 182 ? 227.207 228.360 220.029 1.00 85.49  ? 222 PHE A CG  1 
ATOM 1119 C CD1 . PHE A 1 182 ? 227.732 228.558 221.293 1.00 88.68  ? 222 PHE A CD1 1 
ATOM 1120 C CD2 . PHE A 1 182 ? 225.844 228.179 219.900 1.00 84.48  ? 222 PHE A CD2 1 
ATOM 1121 C CE1 . PHE A 1 182 ? 226.913 228.584 222.401 1.00 84.93  ? 222 PHE A CE1 1 
ATOM 1122 C CE2 . PHE A 1 182 ? 225.022 228.203 221.006 1.00 86.92  ? 222 PHE A CE2 1 
ATOM 1123 C CZ  . PHE A 1 182 ? 225.557 228.405 222.257 1.00 87.39  ? 222 PHE A CZ  1 
ATOM 1124 N N   . GLY A 1 183 ? 227.699 225.366 219.959 1.00 81.54  ? 223 GLY A N   1 
ATOM 1125 C CA  . GLY A 1 183 ? 226.669 224.391 220.248 1.00 83.82  ? 223 GLY A CA  1 
ATOM 1126 C C   . GLY A 1 183 ? 226.997 222.988 219.763 1.00 84.25  ? 223 GLY A C   1 
ATOM 1127 O O   . GLY A 1 183 ? 228.145 222.632 219.494 1.00 86.43  ? 223 GLY A O   1 
ATOM 1128 N N   . GLY A 1 184 ? 225.943 222.182 219.662 1.00 86.72  ? 224 GLY A N   1 
ATOM 1129 C CA  . GLY A 1 184 ? 226.067 220.815 219.199 1.00 88.68  ? 224 GLY A CA  1 
ATOM 1130 C C   . GLY A 1 184 ? 226.299 219.827 220.322 1.00 93.28  ? 224 GLY A C   1 
ATOM 1131 O O   . GLY A 1 184 ? 227.246 219.973 221.098 1.00 99.47  ? 224 GLY A O   1 
ATOM 1132 N N   . THR A 1 185 ? 225.439 218.818 220.423 1.00 92.96  ? 225 THR A N   1 
ATOM 1133 C CA  . THR A 1 185 ? 225.616 217.798 221.442 1.00 98.38  ? 225 THR A CA  1 
ATOM 1134 C C   . THR A 1 185 ? 226.766 216.868 221.077 1.00 103.14 ? 225 THR A C   1 
ATOM 1135 O O   . THR A 1 185 ? 227.182 216.767 219.920 1.00 101.18 ? 225 THR A O   1 
ATOM 1136 C CB  . THR A 1 185 ? 224.346 216.971 221.617 1.00 95.72  ? 225 THR A CB  1 
ATOM 1137 O OG1 . THR A 1 185 ? 224.181 216.110 220.485 1.00 95.34  ? 225 THR A OG1 1 
ATOM 1138 C CG2 . THR A 1 185 ? 223.139 217.870 221.740 1.00 97.90  ? 225 THR A CG2 1 
ATOM 1139 N N   . THR A 1 186 ? 227.281 216.180 222.090 1.00 106.62 ? 226 THR A N   1 
ATOM 1140 C CA  . THR A 1 186 ? 228.253 215.118 221.889 1.00 109.04 ? 226 THR A CA  1 
ATOM 1141 C C   . THR A 1 186 ? 227.600 213.749 221.787 1.00 111.67 ? 226 THR A C   1 
ATOM 1142 O O   . THR A 1 186 ? 228.309 212.747 221.648 1.00 118.25 ? 226 THR A O   1 
ATOM 1143 C CB  . THR A 1 186 ? 229.275 215.107 223.026 1.00 111.20 ? 226 THR A CB  1 
ATOM 1144 O OG1 . THR A 1 186 ? 228.749 214.360 224.128 1.00 112.20 ? 226 THR A OG1 1 
ATOM 1145 C CG2 . THR A 1 186 ? 229.578 216.525 223.479 1.00 111.09 ? 226 THR A CG2 1 
ATOM 1146 N N   . GLY A 1 187 ? 226.273 213.682 221.859 1.00 109.88 ? 227 GLY A N   1 
ATOM 1147 C CA  . GLY A 1 187 ? 225.571 212.417 221.810 1.00 113.69 ? 227 GLY A CA  1 
ATOM 1148 C C   . GLY A 1 187 ? 224.784 212.130 223.071 1.00 121.10 ? 227 GLY A C   1 
ATOM 1149 O O   . GLY A 1 187 ? 223.689 211.564 223.011 1.00 126.12 ? 227 GLY A O   1 
ATOM 1150 N N   . TYR A 1 188 ? 225.334 212.510 224.224 1.00 120.56 ? 228 TYR A N   1 
ATOM 1151 C CA  . TYR A 1 188 ? 224.651 212.290 225.493 1.00 119.51 ? 228 TYR A CA  1 
ATOM 1152 C C   . TYR A 1 188 ? 224.645 213.552 226.346 1.00 119.97 ? 228 TYR A C   1 
ATOM 1153 O O   . TYR A 1 188 ? 223.742 213.748 227.165 1.00 125.06 ? 228 TYR A O   1 
ATOM 1154 C CB  . TYR A 1 188 ? 225.307 211.138 226.257 1.00 113.43 ? 228 TYR A CB  1 
ATOM 1155 N N   . ILE A 1 189 ? 225.641 214.415 226.160 1.00 117.65 ? 229 ILE A N   1 
ATOM 1156 C CA  . ILE A 1 189 ? 225.780 215.641 226.936 1.00 116.62 ? 229 ILE A CA  1 
ATOM 1157 C C   . ILE A 1 189 ? 225.900 216.811 225.970 1.00 113.28 ? 229 ILE A C   1 
ATOM 1158 O O   . ILE A 1 189 ? 226.629 216.729 224.975 1.00 113.64 ? 229 ILE A O   1 
ATOM 1159 C CB  . ILE A 1 189 ? 226.993 215.583 227.886 1.00 118.64 ? 229 ILE A CB  1 
ATOM 1160 C CG1 . ILE A 1 189 ? 227.319 216.972 228.439 1.00 115.08 ? 229 ILE A CG1 1 
ATOM 1161 C CG2 . ILE A 1 189 ? 228.197 214.978 227.187 1.00 120.72 ? 229 ILE A CG2 1 
ATOM 1162 C CD1 . ILE A 1 189 ? 228.492 216.989 229.392 1.00 115.98 ? 229 ILE A CD1 1 
ATOM 1163 N N   . TYR A 1 190 ? 225.180 217.890 226.260 1.00 109.69 ? 230 TYR A N   1 
ATOM 1164 C CA  . TYR A 1 190 ? 225.130 219.047 225.383 1.00 104.85 ? 230 TYR A CA  1 
ATOM 1165 C C   . TYR A 1 190 ? 226.359 219.930 225.586 1.00 106.31 ? 230 TYR A C   1 
ATOM 1166 O O   . TYR A 1 190 ? 227.136 219.760 226.528 1.00 108.73 ? 230 TYR A O   1 
ATOM 1167 C CB  . TYR A 1 190 ? 223.851 219.844 225.628 1.00 99.64  ? 230 TYR A CB  1 
ATOM 1168 C CG  . TYR A 1 190 ? 222.610 219.205 225.049 1.00 99.25  ? 230 TYR A CG  1 
ATOM 1169 C CD1 . TYR A 1 190 ? 222.320 217.869 225.284 1.00 104.97 ? 230 TYR A CD1 1 
ATOM 1170 C CD2 . TYR A 1 190 ? 221.729 219.936 224.269 1.00 99.30  ? 230 TYR A CD2 1 
ATOM 1171 C CE1 . TYR A 1 190 ? 221.193 217.279 224.760 1.00 109.11 ? 230 TYR A CE1 1 
ATOM 1172 C CE2 . TYR A 1 190 ? 220.596 219.353 223.738 1.00 102.43 ? 230 TYR A CE2 1 
ATOM 1173 C CZ  . TYR A 1 190 ? 220.335 218.023 223.988 1.00 106.65 ? 230 TYR A CZ  1 
ATOM 1174 O OH  . TYR A 1 190 ? 219.212 217.428 223.468 1.00 103.81 ? 230 TYR A OH  1 
ATOM 1175 N N   . SER A 1 191 ? 226.529 220.890 224.680 1.00 103.73 ? 231 SER A N   1 
ATOM 1176 C CA  . SER A 1 191 ? 227.671 221.789 224.703 1.00 106.61 ? 231 SER A CA  1 
ATOM 1177 C C   . SER A 1 191 ? 227.206 223.224 224.503 1.00 104.10 ? 231 SER A C   1 
ATOM 1178 O O   . SER A 1 191 ? 226.134 223.484 223.951 1.00 103.37 ? 231 SER A O   1 
ATOM 1179 C CB  . SER A 1 191 ? 228.700 221.421 223.627 1.00 108.52 ? 231 SER A CB  1 
ATOM 1180 O OG  . SER A 1 191 ? 229.629 222.472 223.432 1.00 111.19 ? 231 SER A OG  1 
ATOM 1181 N N   . THR A 1 192 ? 228.032 224.160 224.973 1.00 100.77 ? 232 THR A N   1 
ATOM 1182 C CA  . THR A 1 192 ? 227.745 225.579 224.824 1.00 97.99  ? 232 THR A CA  1 
ATOM 1183 C C   . THR A 1 192 ? 228.984 226.389 224.458 1.00 98.75  ? 232 THR A C   1 
ATOM 1184 O O   . THR A 1 192 ? 228.937 227.621 224.520 1.00 95.12  ? 232 THR A O   1 
ATOM 1185 C CB  . THR A 1 192 ? 227.121 226.133 226.118 1.00 99.59  ? 232 THR A CB  1 
ATOM 1186 O OG1 . THR A 1 192 ? 226.267 225.138 226.692 1.00 107.19 ? 232 THR A OG1 1 
ATOM 1187 C CG2 . THR A 1 192 ? 226.269 227.360 225.827 1.00 97.39  ? 232 THR A CG2 1 
ATOM 1188 N N   . ASP A 1 193 ? 230.083 225.744 224.081 1.00 104.34 ? 233 ASP A N   1 
ATOM 1189 C CA  . ASP A 1 193 ? 231.310 226.462 223.777 1.00 106.79 ? 233 ASP A CA  1 
ATOM 1190 C C   . ASP A 1 193 ? 231.180 227.235 222.467 1.00 98.19  ? 233 ASP A C   1 
ATOM 1191 O O   . ASP A 1 193 ? 230.350 226.929 221.608 1.00 98.28  ? 233 ASP A O   1 
ATOM 1192 C CB  . ASP A 1 193 ? 232.490 225.496 223.707 1.00 112.69 ? 233 ASP A CB  1 
ATOM 1193 C CG  . ASP A 1 193 ? 232.917 225.002 225.073 1.00 118.33 ? 233 ASP A CG  1 
ATOM 1194 O OD1 . ASP A 1 193 ? 233.816 225.623 225.677 1.00 117.45 ? 233 ASP A OD1 1 
ATOM 1195 O OD2 . ASP A 1 193 ? 232.350 223.994 225.545 1.00 120.72 ? 233 ASP A OD2 1 
ATOM 1196 N N   . LEU A 1 194 ? 232.034 228.244 222.320 1.00 89.70  ? 234 LEU A N   1 
ATOM 1197 C CA  . LEU A 1 194 ? 231.995 229.202 221.220 1.00 85.03  ? 234 LEU A CA  1 
ATOM 1198 C C   . LEU A 1 194 ? 233.350 229.262 220.529 1.00 92.32  ? 234 LEU A C   1 
ATOM 1199 O O   . LEU A 1 194 ? 233.957 230.323 220.375 1.00 100.32 ? 234 LEU A O   1 
ATOM 1200 C CB  . LEU A 1 194 ? 231.568 230.578 221.715 1.00 84.93  ? 234 LEU A CB  1 
ATOM 1201 C CG  . LEU A 1 194 ? 231.106 231.560 220.638 1.00 88.27  ? 234 LEU A CG  1 
ATOM 1202 C CD1 . LEU A 1 194 ? 229.633 231.372 220.332 1.00 89.62  ? 234 LEU A CD1 1 
ATOM 1203 C CD2 . LEU A 1 194 ? 231.391 232.980 221.070 1.00 93.60  ? 234 LEU A CD2 1 
ATOM 1204 N N   . HIS A 1 195 ? 233.848 228.098 220.123 1.00 90.80  ? 235 HIS A N   1 
ATOM 1205 C CA  . HIS A 1 195 ? 235.231 227.985 219.678 1.00 93.23  ? 235 HIS A CA  1 
ATOM 1206 C C   . HIS A 1 195 ? 235.497 228.843 218.446 1.00 95.40  ? 235 HIS A C   1 
ATOM 1207 O O   . HIS A 1 195 ? 234.616 229.066 217.610 1.00 95.00  ? 235 HIS A O   1 
ATOM 1208 C CB  . HIS A 1 195 ? 235.568 226.529 219.372 1.00 93.48  ? 235 HIS A CB  1 
ATOM 1209 C CG  . HIS A 1 195 ? 235.828 225.700 220.590 1.00 100.19 ? 235 HIS A CG  1 
ATOM 1210 N ND1 . HIS A 1 195 ? 234.850 224.943 221.197 1.00 103.27 ? 235 HIS A ND1 1 
ATOM 1211 C CD2 . HIS A 1 195 ? 236.957 225.503 221.310 1.00 103.86 ? 235 HIS A CD2 1 
ATOM 1212 C CE1 . HIS A 1 195 ? 235.365 224.317 222.240 1.00 108.01 ? 235 HIS A CE1 1 
ATOM 1213 N NE2 . HIS A 1 195 ? 236.642 224.640 222.331 1.00 107.04 ? 235 HIS A NE2 1 
ATOM 1214 N N   . LYS A 1 196 ? 236.733 229.333 218.344 1.00 97.91  ? 236 LYS A N   1 
ATOM 1215 C CA  . LYS A 1 196 ? 237.168 230.169 217.234 1.00 96.87  ? 236 LYS A CA  1 
ATOM 1216 C C   . LYS A 1 196 ? 238.452 229.606 216.644 1.00 98.88  ? 236 LYS A C   1 
ATOM 1217 O O   . LYS A 1 196 ? 239.388 229.272 217.377 1.00 101.39 ? 236 LYS A O   1 
ATOM 1218 C CB  . LYS A 1 196 ? 237.390 231.616 217.682 1.00 96.02  ? 236 LYS A CB  1 
ATOM 1219 C CG  . LYS A 1 196 ? 238.316 232.406 216.772 1.00 98.08  ? 236 LYS A CG  1 
ATOM 1220 C CD  . LYS A 1 196 ? 238.557 233.808 217.299 1.00 102.80 ? 236 LYS A CD  1 
ATOM 1221 C CE  . LYS A 1 196 ? 239.659 233.822 218.344 1.00 102.25 ? 236 LYS A CE  1 
ATOM 1222 N NZ  . LYS A 1 196 ? 240.979 233.460 217.762 1.00 99.04  ? 236 LYS A NZ  1 
ATOM 1223 N N   . LEU A 1 197 ? 238.495 229.517 215.320 1.00 96.20  ? 237 LEU A N   1 
ATOM 1224 C CA  . LEU A 1 197 ? 239.659 229.046 214.586 1.00 99.75  ? 237 LEU A CA  1 
ATOM 1225 C C   . LEU A 1 197 ? 240.156 230.156 213.673 1.00 104.92 ? 237 LEU A C   1 
ATOM 1226 O O   . LEU A 1 197 ? 239.372 230.744 212.919 1.00 106.50 ? 237 LEU A O   1 
ATOM 1227 C CB  . LEU A 1 197 ? 239.326 227.797 213.767 1.00 97.68  ? 237 LEU A CB  1 
ATOM 1228 C CG  . LEU A 1 197 ? 240.177 227.559 212.520 1.00 99.50  ? 237 LEU A CG  1 
ATOM 1229 C CD1 . LEU A 1 197 ? 241.579 227.117 212.896 1.00 103.34 ? 237 LEU A CD1 1 
ATOM 1230 C CD2 . LEU A 1 197 ? 239.522 226.536 211.612 1.00 99.03  ? 237 LEU A CD2 1 
ATOM 1231 N N   . ASP A 1 198 ? 241.452 230.442 213.749 1.00 107.91 ? 238 ASP A N   1 
ATOM 1232 C CA  . ASP A 1 198 ? 242.100 231.395 212.856 1.00 110.57 ? 238 ASP A CA  1 
ATOM 1233 C C   . ASP A 1 198 ? 242.575 230.638 211.622 1.00 116.28 ? 238 ASP A C   1 
ATOM 1234 O O   . ASP A 1 198 ? 243.461 229.779 211.714 1.00 118.59 ? 238 ASP A O   1 
ATOM 1235 C CB  . ASP A 1 198 ? 243.261 232.094 213.558 1.00 107.76 ? 238 ASP A CB  1 
ATOM 1236 N N   . LEU A 1 199 ? 241.976 230.950 210.470 1.00 115.23 ? 239 LEU A N   1 
ATOM 1237 C CA  . LEU A 1 199 ? 242.299 230.231 209.243 1.00 114.92 ? 239 LEU A CA  1 
ATOM 1238 C C   . LEU A 1 199 ? 243.655 230.638 208.686 1.00 122.78 ? 239 LEU A C   1 
ATOM 1239 O O   . LEU A 1 199 ? 244.332 229.818 208.055 1.00 124.82 ? 239 LEU A O   1 
ATOM 1240 C CB  . LEU A 1 199 ? 241.211 230.463 208.197 1.00 113.56 ? 239 LEU A CB  1 
ATOM 1241 C CG  . LEU A 1 199 ? 239.854 229.821 208.480 1.00 111.40 ? 239 LEU A CG  1 
ATOM 1242 C CD1 . LEU A 1 199 ? 238.747 230.856 208.386 1.00 105.36 ? 239 LEU A CD1 1 
ATOM 1243 C CD2 . LEU A 1 199 ? 239.600 228.672 207.520 1.00 115.07 ? 239 LEU A CD2 1 
ATOM 1244 N N   . ASN A 1 200 ? 244.062 231.892 208.890 1.00 125.63 ? 240 ASN A N   1 
ATOM 1245 C CA  . ASN A 1 200 ? 245.360 232.332 208.390 1.00 128.44 ? 240 ASN A CA  1 
ATOM 1246 C C   . ASN A 1 200 ? 246.493 231.554 209.044 1.00 127.09 ? 240 ASN A C   1 
ATOM 1247 O O   . ASN A 1 200 ? 247.441 231.135 208.370 1.00 129.20 ? 240 ASN A O   1 
ATOM 1248 C CB  . ASN A 1 200 ? 245.532 233.832 208.622 1.00 131.96 ? 240 ASN A CB  1 
ATOM 1249 C CG  . ASN A 1 200 ? 245.432 234.632 207.341 1.00 143.19 ? 240 ASN A CG  1 
ATOM 1250 O OD1 . ASN A 1 200 ? 245.987 234.249 206.312 1.00 146.96 ? 240 ASN A OD1 1 
ATOM 1251 N ND2 . ASN A 1 200 ? 244.721 235.752 207.397 1.00 148.94 ? 240 ASN A ND2 1 
ATOM 1252 N N   . THR A 1 201 ? 246.412 231.347 210.356 1.00 122.94 ? 241 THR A N   1 
ATOM 1253 C CA  . THR A 1 201 ? 247.381 230.532 211.072 1.00 122.42 ? 241 THR A CA  1 
ATOM 1254 C C   . THR A 1 201 ? 246.852 229.146 211.413 1.00 121.91 ? 241 THR A C   1 
ATOM 1255 O O   . THR A 1 201 ? 247.616 228.323 211.928 1.00 123.21 ? 241 THR A O   1 
ATOM 1256 C CB  . THR A 1 201 ? 247.821 231.237 212.360 1.00 122.19 ? 241 THR A CB  1 
ATOM 1257 O OG1 . THR A 1 201 ? 246.807 231.084 213.360 1.00 121.99 ? 241 THR A OG1 1 
ATOM 1258 C CG2 . THR A 1 201 ? 248.050 232.716 212.102 1.00 122.47 ? 241 THR A CG2 1 
ATOM 1259 N N   . ARG A 1 202 ? 245.578 228.873 211.134 1.00 120.24 ? 242 ARG A N   1 
ATOM 1260 C CA  . ARG A 1 202 ? 244.954 227.583 211.424 1.00 117.19 ? 242 ARG A CA  1 
ATOM 1261 C C   . ARG A 1 202 ? 245.123 227.212 212.895 1.00 117.74 ? 242 ARG A C   1 
ATOM 1262 O O   . ARG A 1 202 ? 245.545 226.107 213.242 1.00 116.85 ? 242 ARG A O   1 
ATOM 1263 C CB  . ARG A 1 202 ? 245.509 226.489 210.511 1.00 116.01 ? 242 ARG A CB  1 
ATOM 1264 C CG  . ARG A 1 202 ? 245.031 226.588 209.073 1.00 118.77 ? 242 ARG A CG  1 
ATOM 1265 C CD  . ARG A 1 202 ? 245.830 225.681 208.157 1.00 119.72 ? 242 ARG A CD  1 
ATOM 1266 N NE  . ARG A 1 202 ? 245.662 226.045 206.756 1.00 127.72 ? 242 ARG A NE  1 
ATOM 1267 C CZ  . ARG A 1 202 ? 246.385 225.548 205.761 1.00 134.92 ? 242 ARG A CZ  1 
ATOM 1268 N NH1 . ARG A 1 202 ? 247.338 224.656 205.978 1.00 134.31 ? 242 ARG A NH1 1 
ATOM 1269 N NH2 . ARG A 1 202 ? 246.146 225.956 204.518 1.00 132.88 ? 242 ARG A NH2 1 
ATOM 1270 N N   . GLU A 1 203 ? 244.789 228.156 213.769 1.00 118.94 ? 243 GLU A N   1 
ATOM 1271 C CA  . GLU A 1 203 ? 244.965 227.992 215.206 1.00 117.43 ? 243 GLU A CA  1 
ATOM 1272 C C   . GLU A 1 203 ? 243.608 227.932 215.894 1.00 114.81 ? 243 GLU A C   1 
ATOM 1273 O O   . GLU A 1 203 ? 242.784 228.836 215.726 1.00 111.35 ? 243 GLU A O   1 
ATOM 1274 C CB  . GLU A 1 203 ? 245.799 229.134 215.788 1.00 117.26 ? 243 GLU A CB  1 
ATOM 1275 C CG  . GLU A 1 203 ? 246.125 228.971 217.259 1.00 122.00 ? 243 GLU A CG  1 
ATOM 1276 C CD  . GLU A 1 203 ? 247.469 229.565 217.623 1.00 137.13 ? 243 GLU A CD  1 
ATOM 1277 O OE1 . GLU A 1 203 ? 248.165 230.063 216.714 1.00 139.05 ? 243 GLU A OE1 1 
ATOM 1278 O OE2 . GLU A 1 203 ? 247.831 229.532 218.818 1.00 147.30 ? 243 GLU A OE2 1 
ATOM 1279 N N   . TRP A 1 204 ? 243.383 226.872 216.664 1.00 112.97 ? 244 TRP A N   1 
ATOM 1280 C CA  . TRP A 1 204 ? 242.140 226.687 217.397 1.00 104.87 ? 244 TRP A CA  1 
ATOM 1281 C C   . TRP A 1 204 ? 242.231 227.335 218.771 1.00 106.73 ? 244 TRP A C   1 
ATOM 1282 O O   . TRP A 1 204 ? 243.297 227.372 219.390 1.00 112.84 ? 244 TRP A O   1 
ATOM 1283 C CB  . TRP A 1 204 ? 241.826 225.199 217.555 1.00 99.83  ? 244 TRP A CB  1 
ATOM 1284 C CG  . TRP A 1 204 ? 240.928 224.645 216.499 1.00 100.34 ? 244 TRP A CG  1 
ATOM 1285 C CD1 . TRP A 1 204 ? 241.242 223.694 215.576 1.00 103.44 ? 244 TRP A CD1 1 
ATOM 1286 C CD2 . TRP A 1 204 ? 239.562 224.998 216.262 1.00 98.77  ? 244 TRP A CD2 1 
ATOM 1287 N NE1 . TRP A 1 204 ? 240.159 223.435 214.775 1.00 96.50  ? 244 TRP A NE1 1 
ATOM 1288 C CE2 . TRP A 1 204 ? 239.114 224.224 215.176 1.00 97.19  ? 244 TRP A CE2 1 
ATOM 1289 C CE3 . TRP A 1 204 ? 238.675 225.897 216.860 1.00 97.94  ? 244 TRP A CE3 1 
ATOM 1290 C CZ2 . TRP A 1 204 ? 237.819 224.320 214.676 1.00 95.44  ? 244 TRP A CZ2 1 
ATOM 1291 C CZ3 . TRP A 1 204 ? 237.391 225.990 216.363 1.00 94.81  ? 244 TRP A CZ3 1 
ATOM 1292 C CH2 . TRP A 1 204 ? 236.975 225.207 215.282 1.00 96.63  ? 244 TRP A CH2 1 
ATOM 1293 N N   . THR A 1 205 ? 241.097 227.842 219.251 1.00 104.27 ? 245 THR A N   1 
ATOM 1294 C CA  . THR A 1 205 ? 241.031 228.365 220.607 1.00 103.83 ? 245 THR A CA  1 
ATOM 1295 C C   . THR A 1 205 ? 239.581 228.370 221.064 1.00 100.70 ? 245 THR A C   1 
ATOM 1296 O O   . THR A 1 205 ? 238.653 228.304 220.254 1.00 102.75 ? 245 THR A O   1 
ATOM 1297 C CB  . THR A 1 205 ? 241.630 229.772 220.706 1.00 105.37 ? 245 THR A CB  1 
ATOM 1298 O OG1 . THR A 1 205 ? 241.537 230.237 222.058 1.00 112.19 ? 245 THR A OG1 1 
ATOM 1299 C CG2 . THR A 1 205 ? 240.888 230.730 219.798 1.00 100.04 ? 245 THR A CG2 1 
ATOM 1300 N N   . GLN A 1 206 ? 239.400 228.447 222.378 1.00 97.82  ? 246 GLN A N   1 
ATOM 1301 C CA  . GLN A 1 206 ? 238.084 228.462 222.997 1.00 98.30  ? 246 GLN A CA  1 
ATOM 1302 C C   . GLN A 1 206 ? 237.793 229.859 223.521 1.00 99.29  ? 246 GLN A C   1 
ATOM 1303 O O   . GLN A 1 206 ? 238.640 230.466 224.183 1.00 103.21 ? 246 GLN A O   1 
ATOM 1304 C CB  . GLN A 1 206 ? 238.002 227.443 224.135 1.00 104.91 ? 246 GLN A CB  1 
ATOM 1305 C CG  . GLN A 1 206 ? 236.586 227.069 224.534 1.00 110.43 ? 246 GLN A CG  1 
ATOM 1306 C CD  . GLN A 1 206 ? 236.031 227.956 225.629 1.00 114.72 ? 246 GLN A CD  1 
ATOM 1307 O OE1 . GLN A 1 206 ? 236.731 228.817 226.162 1.00 116.66 ? 246 GLN A OE1 1 
ATOM 1308 N NE2 . GLN A 1 206 ? 234.764 227.751 225.972 1.00 112.19 ? 246 GLN A NE2 1 
ATOM 1309 N N   . LEU A 1 207 ? 236.599 230.362 223.229 1.00 97.00  ? 247 LEU A N   1 
ATOM 1310 C CA  . LEU A 1 207 ? 236.186 231.683 223.681 1.00 97.71  ? 247 LEU A CA  1 
ATOM 1311 C C   . LEU A 1 207 ? 235.538 231.563 225.053 1.00 101.99 ? 247 LEU A C   1 
ATOM 1312 O O   . LEU A 1 207 ? 234.513 230.890 225.205 1.00 107.81 ? 247 LEU A O   1 
ATOM 1313 C CB  . LEU A 1 207 ? 235.221 232.319 222.683 1.00 95.18  ? 247 LEU A CB  1 
ATOM 1314 C CG  . LEU A 1 207 ? 235.834 232.869 221.395 1.00 95.47  ? 247 LEU A CG  1 
ATOM 1315 C CD1 . LEU A 1 207 ? 234.984 234.004 220.853 1.00 96.95  ? 247 LEU A CD1 1 
ATOM 1316 C CD2 . LEU A 1 207 ? 237.262 233.331 221.625 1.00 97.16  ? 247 LEU A CD2 1 
ATOM 1317 N N   . LYS A 1 208 ? 236.135 232.212 226.047 1.00 100.54 ? 248 LYS A N   1 
ATOM 1318 C CA  . LYS A 1 208 ? 235.618 232.185 227.410 1.00 101.45 ? 248 LYS A CA  1 
ATOM 1319 C C   . LYS A 1 208 ? 235.034 233.545 227.761 1.00 102.04 ? 248 LYS A C   1 
ATOM 1320 O O   . LYS A 1 208 ? 235.790 234.521 227.891 1.00 100.28 ? 248 LYS A O   1 
ATOM 1321 C CB  . LYS A 1 208 ? 236.720 231.806 228.399 1.00 98.08  ? 248 LYS A CB  1 
ATOM 1322 N N   . PRO A 1 209 ? 233.709 233.668 227.921 1.00 101.15 ? 249 PRO A N   1 
ATOM 1323 C CA  . PRO A 1 209 ? 233.051 234.931 228.272 1.00 103.06 ? 249 PRO A CA  1 
ATOM 1324 C C   . PRO A 1 209 ? 233.490 235.473 229.629 1.00 102.89 ? 249 PRO A C   1 
ATOM 1325 O O   . PRO A 1 209 ? 234.141 234.751 230.382 1.00 101.83 ? 249 PRO A O   1 
ATOM 1326 C CB  . PRO A 1 209 ? 231.565 234.557 228.296 1.00 96.60  ? 249 PRO A CB  1 
ATOM 1327 C CG  . PRO A 1 209 ? 231.466 233.343 227.444 1.00 90.80  ? 249 PRO A CG  1 
ATOM 1328 C CD  . PRO A 1 209 ? 232.734 232.592 227.682 1.00 93.56  ? 249 PRO A CD  1 
ATOM 1329 N N   . LEU A 1 216 ? 224.054 233.309 230.400 1.00 93.33  ? 256 LEU A N   1 
ATOM 1330 C CA  . LEU A 1 216 ? 224.533 232.279 229.488 1.00 103.89 ? 256 LEU A CA  1 
ATOM 1331 C C   . LEU A 1 216 ? 223.361 231.576 228.812 1.00 107.50 ? 256 LEU A C   1 
ATOM 1332 O O   . LEU A 1 216 ? 222.404 231.183 229.477 1.00 108.10 ? 256 LEU A O   1 
ATOM 1333 C CB  . LEU A 1 216 ? 225.399 231.261 230.233 1.00 102.21 ? 256 LEU A CB  1 
ATOM 1334 C CG  . LEU A 1 216 ? 226.490 230.553 229.428 1.00 93.85  ? 256 LEU A CG  1 
ATOM 1335 C CD1 . LEU A 1 216 ? 227.357 231.559 228.695 1.00 90.46  ? 256 LEU A CD1 1 
ATOM 1336 C CD2 . LEU A 1 216 ? 227.337 229.672 230.329 1.00 91.50  ? 256 LEU A CD2 1 
ATOM 1337 N N   . PRO A 1 217 ? 223.433 231.422 227.492 1.00 105.12 ? 257 PRO A N   1 
ATOM 1338 C CA  . PRO A 1 217 ? 222.352 230.745 226.772 1.00 105.52 ? 257 PRO A CA  1 
ATOM 1339 C C   . PRO A 1 217 ? 222.245 229.282 227.169 1.00 107.22 ? 257 PRO A C   1 
ATOM 1340 O O   . PRO A 1 217 ? 223.222 228.647 227.570 1.00 106.69 ? 257 PRO A O   1 
ATOM 1341 C CB  . PRO A 1 217 ? 222.758 230.891 225.301 1.00 99.57  ? 257 PRO A CB  1 
ATOM 1342 C CG  . PRO A 1 217 ? 224.234 231.080 225.339 1.00 99.41  ? 257 PRO A CG  1 
ATOM 1343 C CD  . PRO A 1 217 ? 224.504 231.867 226.585 1.00 98.91  ? 257 PRO A CD  1 
ATOM 1344 N N   . GLU A 1 218 ? 221.030 228.753 227.058 1.00 109.22 ? 258 GLU A N   1 
ATOM 1345 C CA  . GLU A 1 218 ? 220.795 227.353 227.370 1.00 108.13 ? 258 GLU A CA  1 
ATOM 1346 C C   . GLU A 1 218 ? 221.520 226.454 226.378 1.00 105.12 ? 258 GLU A C   1 
ATOM 1347 O O   . GLU A 1 218 ? 221.781 226.834 225.233 1.00 104.57 ? 258 GLU A O   1 
ATOM 1348 C CB  . GLU A 1 218 ? 219.299 227.040 227.352 1.00 108.99 ? 258 GLU A CB  1 
ATOM 1349 C CG  . GLU A 1 218 ? 218.482 227.829 228.357 1.00 115.06 ? 258 GLU A CG  1 
ATOM 1350 C CD  . GLU A 1 218 ? 217.774 229.010 227.727 1.00 121.36 ? 258 GLU A CD  1 
ATOM 1351 O OE1 . GLU A 1 218 ? 218.136 229.385 226.593 1.00 117.89 ? 258 GLU A OE1 1 
ATOM 1352 O OE2 . GLU A 1 218 ? 216.854 229.563 228.365 1.00 128.94 ? 258 GLU A OE2 1 
ATOM 1353 N N   . GLU A 1 219 ? 221.858 225.252 226.834 1.00 103.28 ? 259 GLU A N   1 
ATOM 1354 C CA  . GLU A 1 219 ? 222.464 224.268 225.951 1.00 103.31 ? 259 GLU A CA  1 
ATOM 1355 C C   . GLU A 1 219 ? 221.468 223.853 224.877 1.00 103.53 ? 259 GLU A C   1 
ATOM 1356 O O   . GLU A 1 219 ? 220.299 223.588 225.168 1.00 106.62 ? 259 GLU A O   1 
ATOM 1357 C CB  . GLU A 1 219 ? 222.918 223.053 226.756 1.00 109.66 ? 259 GLU A CB  1 
ATOM 1358 C CG  . GLU A 1 219 ? 223.260 223.364 228.202 1.00 116.07 ? 259 GLU A CG  1 
ATOM 1359 C CD  . GLU A 1 219 ? 223.710 222.137 228.970 1.00 122.73 ? 259 GLU A CD  1 
ATOM 1360 O OE1 . GLU A 1 219 ? 223.194 221.036 228.688 1.00 124.11 ? 259 GLU A OE1 1 
ATOM 1361 O OE2 . GLU A 1 219 ? 224.582 222.275 229.853 1.00 124.88 ? 259 GLU A OE2 1 
ATOM 1362 N N   . ARG A 1 220 ? 221.933 223.798 223.632 1.00 99.17  ? 260 ARG A N   1 
ATOM 1363 C CA  . ARG A 1 220 ? 221.046 223.508 222.516 1.00 93.67  ? 260 ARG A CA  1 
ATOM 1364 C C   . ARG A 1 220 ? 221.852 222.920 221.370 1.00 91.53  ? 260 ARG A C   1 
ATOM 1365 O O   . ARG A 1 220 ? 223.079 223.032 221.326 1.00 93.92  ? 260 ARG A O   1 
ATOM 1366 C CB  . ARG A 1 220 ? 220.304 224.765 222.051 1.00 94.54  ? 260 ARG A CB  1 
ATOM 1367 C CG  . ARG A 1 220 ? 221.198 225.780 221.363 1.00 93.50  ? 260 ARG A CG  1 
ATOM 1368 C CD  . ARG A 1 220 ? 220.443 227.054 221.034 1.00 95.21  ? 260 ARG A CD  1 
ATOM 1369 N NE  . ARG A 1 220 ? 220.220 227.879 222.214 1.00 98.97  ? 260 ARG A NE  1 
ATOM 1370 C CZ  . ARG A 1 220 ? 219.193 228.702 222.366 1.00 103.28 ? 260 ARG A CZ  1 
ATOM 1371 N NH1 . ARG A 1 220 ? 218.269 228.834 221.430 1.00 104.02 ? 260 ARG A NH1 1 
ATOM 1372 N NH2 . ARG A 1 220 ? 219.090 229.411 223.486 1.00 106.45 ? 260 ARG A NH2 1 
ATOM 1373 N N   . TYR A 1 221 ? 221.137 222.292 220.441 1.00 91.25  ? 261 TYR A N   1 
ATOM 1374 C CA  . TYR A 1 221 ? 221.733 221.753 219.229 1.00 90.86  ? 261 TYR A CA  1 
ATOM 1375 C C   . TYR A 1 221 ? 220.746 221.911 218.083 1.00 88.55  ? 261 TYR A C   1 
ATOM 1376 O O   . TYR A 1 221 ? 219.544 222.088 218.292 1.00 90.92  ? 261 TYR A O   1 
ATOM 1377 C CB  . TYR A 1 221 ? 222.136 220.283 219.398 1.00 90.15  ? 261 TYR A CB  1 
ATOM 1378 C CG  . TYR A 1 221 ? 221.125 219.285 218.881 1.00 89.11  ? 261 TYR A CG  1 
ATOM 1379 C CD1 . TYR A 1 221 ? 219.896 219.123 219.505 1.00 91.53  ? 261 TYR A CD1 1 
ATOM 1380 C CD2 . TYR A 1 221 ? 221.406 218.494 217.777 1.00 85.84  ? 261 TYR A CD2 1 
ATOM 1381 C CE1 . TYR A 1 221 ? 218.974 218.210 219.039 1.00 88.62  ? 261 TYR A CE1 1 
ATOM 1382 C CE2 . TYR A 1 221 ? 220.490 217.578 217.304 1.00 84.15  ? 261 TYR A CE2 1 
ATOM 1383 C CZ  . TYR A 1 221 ? 219.276 217.441 217.939 1.00 84.60  ? 261 TYR A CZ  1 
ATOM 1384 O OH  . TYR A 1 221 ? 218.358 216.531 217.474 1.00 90.15  ? 261 TYR A OH  1 
ATOM 1385 N N   . ARG A 1 222 ? 221.277 221.842 216.862 1.00 83.13  ? 262 ARG A N   1 
ATOM 1386 C CA  . ARG A 1 222 ? 220.495 222.070 215.648 1.00 82.68  ? 262 ARG A CA  1 
ATOM 1387 C C   . ARG A 1 222 ? 219.835 223.448 215.671 1.00 87.94  ? 262 ARG A C   1 
ATOM 1388 O O   . ARG A 1 222 ? 218.683 223.615 215.269 1.00 91.28  ? 262 ARG A O   1 
ATOM 1389 C CB  . ARG A 1 222 ? 219.460 220.964 215.441 1.00 83.57  ? 262 ARG A CB  1 
ATOM 1390 C CG  . ARG A 1 222 ? 219.128 220.693 213.990 1.00 87.93  ? 262 ARG A CG  1 
ATOM 1391 C CD  . ARG A 1 222 ? 220.294 220.081 213.243 1.00 91.21  ? 262 ARG A CD  1 
ATOM 1392 N NE  . ARG A 1 222 ? 220.233 220.405 211.823 1.00 100.19 ? 262 ARG A NE  1 
ATOM 1393 C CZ  . ARG A 1 222 ? 220.465 219.539 210.847 1.00 96.86  ? 262 ARG A CZ  1 
ATOM 1394 N NH1 . ARG A 1 222 ? 220.791 218.283 211.101 1.00 94.03  ? 262 ARG A NH1 1 
ATOM 1395 N NH2 . ARG A 1 222 ? 220.365 219.943 209.585 1.00 90.19  ? 262 ARG A NH2 1 
ATOM 1396 N N   . HIS A 1 223 ? 220.574 224.439 216.160 1.00 87.85  ? 263 HIS A N   1 
ATOM 1397 C CA  . HIS A 1 223 ? 220.154 225.831 216.138 1.00 86.01  ? 263 HIS A CA  1 
ATOM 1398 C C   . HIS A 1 223 ? 220.700 226.494 214.876 1.00 89.11  ? 263 HIS A C   1 
ATOM 1399 O O   . HIS A 1 223 ? 221.220 225.828 213.978 1.00 96.39  ? 263 HIS A O   1 
ATOM 1400 C CB  . HIS A 1 223 ? 220.631 226.541 217.398 1.00 88.89  ? 263 HIS A CB  1 
ATOM 1401 C CG  . HIS A 1 223 ? 222.066 226.276 217.722 1.00 88.59  ? 263 HIS A CG  1 
ATOM 1402 N ND1 . HIS A 1 223 ? 222.485 225.122 218.346 1.00 90.29  ? 263 HIS A ND1 1 
ATOM 1403 C CD2 . HIS A 1 223 ? 223.181 227.006 217.492 1.00 88.30  ? 263 HIS A CD2 1 
ATOM 1404 C CE1 . HIS A 1 223 ? 223.797 225.157 218.495 1.00 88.72  ? 263 HIS A CE1 1 
ATOM 1405 N NE2 . HIS A 1 223 ? 224.244 226.289 217.984 1.00 87.77  ? 263 HIS A NE2 1 
ATOM 1406 N N   . GLU A 1 224 ? 220.603 227.818 214.796 1.00 88.24  ? 264 GLU A N   1 
ATOM 1407 C CA  . GLU A 1 224 ? 221.091 228.540 213.632 1.00 93.83  ? 264 GLU A CA  1 
ATOM 1408 C C   . GLU A 1 224 ? 221.810 229.810 214.063 1.00 94.61  ? 264 GLU A C   1 
ATOM 1409 O O   . GLU A 1 224 ? 221.534 230.374 215.125 1.00 98.54  ? 264 GLU A O   1 
ATOM 1410 C CB  . GLU A 1 224 ? 219.950 228.873 212.667 1.00 96.77  ? 264 GLU A CB  1 
ATOM 1411 C CG  . GLU A 1 224 ? 219.420 227.667 211.903 1.00 98.90  ? 264 GLU A CG  1 
ATOM 1412 C CD  . GLU A 1 224 ? 220.517 226.877 211.212 1.00 104.39 ? 264 GLU A CD  1 
ATOM 1413 O OE1 . GLU A 1 224 ? 221.409 227.499 210.601 1.00 107.14 ? 264 GLU A OE1 1 
ATOM 1414 O OE2 . GLU A 1 224 ? 220.483 225.630 211.276 1.00 101.92 ? 264 GLU A OE2 1 
ATOM 1415 N N   . ILE A 1 225 ? 222.726 230.261 213.208 1.00 91.01  ? 265 ILE A N   1 
ATOM 1416 C CA  . ILE A 1 225 ? 223.630 231.366 213.500 1.00 89.62  ? 265 ILE A CA  1 
ATOM 1417 C C   . ILE A 1 225 ? 223.358 232.500 212.525 1.00 94.18  ? 265 ILE A C   1 
ATOM 1418 O O   . ILE A 1 225 ? 223.219 232.269 211.319 1.00 95.19  ? 265 ILE A O   1 
ATOM 1419 C CB  . ILE A 1 225 ? 225.103 230.925 213.411 1.00 89.94  ? 265 ILE A CB  1 
ATOM 1420 C CG1 . ILE A 1 225 ? 225.510 230.153 214.659 1.00 90.19  ? 265 ILE A CG1 1 
ATOM 1421 C CG2 . ILE A 1 225 ? 226.017 232.123 213.224 1.00 88.98  ? 265 ILE A CG2 1 
ATOM 1422 C CD1 . ILE A 1 225 ? 225.329 230.932 215.920 1.00 92.05  ? 265 ILE A CD1 1 
ATOM 1423 N N   . ALA A 1 226 ? 223.281 233.720 213.049 1.00 98.13  ? 266 ALA A N   1 
ATOM 1424 C CA  . ALA A 1 226 ? 223.304 234.927 212.240 1.00 92.80  ? 266 ALA A CA  1 
ATOM 1425 C C   . ALA A 1 226 ? 224.454 235.805 212.708 1.00 95.92  ? 266 ALA A C   1 
ATOM 1426 O O   . ALA A 1 226 ? 224.927 235.679 213.837 1.00 99.06  ? 266 ALA A O   1 
ATOM 1427 C CB  . ALA A 1 226 ? 221.981 235.691 212.336 1.00 88.50  ? 266 ALA A CB  1 
ATOM 1428 N N   . HIS A 1 227 ? 224.914 236.699 211.839 1.00 92.40  ? 267 HIS A N   1 
ATOM 1429 C CA  . HIS A 1 227 ? 225.994 237.589 212.241 1.00 91.15  ? 267 HIS A CA  1 
ATOM 1430 C C   . HIS A 1 227 ? 225.947 238.860 211.410 1.00 96.20  ? 267 HIS A C   1 
ATOM 1431 O O   . HIS A 1 227 ? 225.378 238.891 210.317 1.00 101.80 ? 267 HIS A O   1 
ATOM 1432 C CB  . HIS A 1 227 ? 227.359 236.911 212.109 1.00 88.96  ? 267 HIS A CB  1 
ATOM 1433 C CG  . HIS A 1 227 ? 227.828 236.769 210.696 1.00 94.70  ? 267 HIS A CG  1 
ATOM 1434 N ND1 . HIS A 1 227 ? 228.711 237.651 210.113 1.00 99.93  ? 267 HIS A ND1 1 
ATOM 1435 C CD2 . HIS A 1 227 ? 227.540 235.844 209.751 1.00 99.10  ? 267 HIS A CD2 1 
ATOM 1436 C CE1 . HIS A 1 227 ? 228.946 237.277 208.868 1.00 101.22 ? 267 HIS A CE1 1 
ATOM 1437 N NE2 . HIS A 1 227 ? 228.247 236.183 208.623 1.00 102.36 ? 267 HIS A NE2 1 
ATOM 1438 N N   . ASP A 1 228 ? 226.564 239.914 211.953 1.00 96.42  ? 268 ASP A N   1 
ATOM 1439 C CA  . ASP A 1 228 ? 226.653 241.193 211.258 1.00 97.95  ? 268 ASP A CA  1 
ATOM 1440 C C   . ASP A 1 228 ? 228.051 241.794 211.347 1.00 100.25 ? 268 ASP A C   1 
ATOM 1441 O O   . ASP A 1 228 ? 228.220 242.989 211.079 1.00 104.16 ? 268 ASP A O   1 
ATOM 1442 C CB  . ASP A 1 228 ? 225.625 242.190 211.807 1.00 99.56  ? 268 ASP A CB  1 
ATOM 1443 C CG  . ASP A 1 228 ? 225.687 242.329 213.317 1.00 101.08 ? 268 ASP A CG  1 
ATOM 1444 O OD1 . ASP A 1 228 ? 226.746 242.038 213.910 1.00 102.61 ? 268 ASP A OD1 1 
ATOM 1445 O OD2 . ASP A 1 228 ? 224.669 242.735 213.916 1.00 102.89 ? 268 ASP A OD2 1 
ATOM 1446 N N   . GLY A 1 229 ? 229.053 241.002 211.724 1.00 101.42 ? 269 GLY A N   1 
ATOM 1447 C CA  . GLY A 1 229 ? 230.410 241.482 211.849 1.00 105.57 ? 269 GLY A CA  1 
ATOM 1448 C C   . GLY A 1 229 ? 230.773 242.036 213.208 1.00 105.35 ? 269 GLY A C   1 
ATOM 1449 O O   . GLY A 1 229 ? 231.947 242.353 213.435 1.00 110.06 ? 269 GLY A O   1 
ATOM 1450 N N   . GLN A 1 230 ? 229.811 242.168 214.119 1.00 102.35 ? 270 GLN A N   1 
ATOM 1451 C CA  . GLN A 1 230 ? 230.101 242.666 215.456 1.00 101.22 ? 270 GLN A CA  1 
ATOM 1452 C C   . GLN A 1 230 ? 229.527 241.735 216.515 1.00 101.01 ? 270 GLN A C   1 
ATOM 1453 O O   . GLN A 1 230 ? 230.071 241.630 217.618 1.00 101.64 ? 270 GLN A O   1 
ATOM 1454 C CB  . GLN A 1 230 ? 229.546 244.081 215.633 1.00 97.26  ? 270 GLN A CB  1 
ATOM 1455 N N   . ARG A 1 231 ? 228.427 241.059 216.192 1.00 100.56 ? 271 ARG A N   1 
ATOM 1456 C CA  . ARG A 1 231 ? 227.763 240.168 217.130 1.00 96.43  ? 271 ARG A CA  1 
ATOM 1457 C C   . ARG A 1 231 ? 227.290 238.921 216.399 1.00 98.36  ? 271 ARG A C   1 
ATOM 1458 O O   . ARG A 1 231 ? 227.081 238.927 215.184 1.00 99.22  ? 271 ARG A O   1 
ATOM 1459 C CB  . ARG A 1 231 ? 226.576 240.853 217.820 1.00 94.24  ? 271 ARG A CB  1 
ATOM 1460 C CG  . ARG A 1 231 ? 226.935 242.127 218.563 1.00 96.97  ? 271 ARG A CG  1 
ATOM 1461 C CD  . ARG A 1 231 ? 226.013 242.353 219.745 1.00 98.57  ? 271 ARG A CD  1 
ATOM 1462 N NE  . ARG A 1 231 ? 224.679 242.760 219.323 1.00 103.17 ? 271 ARG A NE  1 
ATOM 1463 C CZ  . ARG A 1 231 ? 224.028 243.806 219.814 1.00 109.99 ? 271 ARG A CZ  1 
ATOM 1464 N NH1 . ARG A 1 231 ? 224.563 244.576 220.747 1.00 109.81 ? 271 ARG A NH1 1 
ATOM 1465 N NH2 . ARG A 1 231 ? 222.811 244.086 219.357 1.00 109.84 ? 271 ARG A NH2 1 
ATOM 1466 N N   . ILE A 1 232 ? 227.125 237.845 217.162 1.00 98.25  ? 272 ILE A N   1 
ATOM 1467 C CA  . ILE A 1 232 ? 226.622 236.573 216.651 1.00 92.12  ? 272 ILE A CA  1 
ATOM 1468 C C   . ILE A 1 232 ? 225.304 236.278 217.352 1.00 91.42  ? 272 ILE A C   1 
ATOM 1469 O O   . ILE A 1 232 ? 225.256 236.206 218.584 1.00 94.44  ? 272 ILE A O   1 
ATOM 1470 C CB  . ILE A 1 232 ? 227.623 235.429 216.869 1.00 90.38  ? 272 ILE A CB  1 
ATOM 1471 C CG1 . ILE A 1 232 ? 229.036 235.873 216.497 1.00 90.92  ? 272 ILE A CG1 1 
ATOM 1472 C CG2 . ILE A 1 232 ? 227.221 234.212 216.060 1.00 87.69  ? 272 ILE A CG2 1 
ATOM 1473 C CD1 . ILE A 1 232 ? 230.058 234.768 216.599 1.00 87.37  ? 272 ILE A CD1 1 
ATOM 1474 N N   . TYR A 1 233 ? 224.246 236.095 216.570 1.00 87.74  ? 273 TYR A N   1 
ATOM 1475 C CA  . TYR A 1 233 ? 222.901 235.896 217.085 1.00 87.66  ? 273 TYR A CA  1 
ATOM 1476 C C   . TYR A 1 233 ? 222.506 234.430 216.971 1.00 86.96  ? 273 TYR A C   1 
ATOM 1477 O O   . TYR A 1 233 ? 222.749 233.788 215.943 1.00 89.24  ? 273 TYR A O   1 
ATOM 1478 C CB  . TYR A 1 233 ? 221.889 236.759 216.329 1.00 86.63  ? 273 TYR A CB  1 
ATOM 1479 C CG  . TYR A 1 233 ? 222.276 238.215 216.215 1.00 90.54  ? 273 TYR A CG  1 
ATOM 1480 C CD1 . TYR A 1 233 ? 223.125 238.651 215.210 1.00 91.40  ? 273 TYR A CD1 1 
ATOM 1481 C CD2 . TYR A 1 233 ? 221.787 239.155 217.110 1.00 93.41  ? 273 TYR A CD2 1 
ATOM 1482 C CE1 . TYR A 1 233 ? 223.481 239.977 215.102 1.00 95.62  ? 273 TYR A CE1 1 
ATOM 1483 C CE2 . TYR A 1 233 ? 222.138 240.485 217.009 1.00 94.63  ? 273 TYR A CE2 1 
ATOM 1484 C CZ  . TYR A 1 233 ? 222.985 240.890 216.004 1.00 98.22  ? 273 TYR A CZ  1 
ATOM 1485 O OH  . TYR A 1 233 ? 223.338 242.214 215.898 1.00 104.13 ? 273 TYR A OH  1 
ATOM 1486 N N   . ILE A 1 234 ? 221.882 233.916 218.029 1.00 84.83  ? 274 ILE A N   1 
ATOM 1487 C CA  . ILE A 1 234 ? 221.427 232.533 218.098 1.00 81.53  ? 274 ILE A CA  1 
ATOM 1488 C C   . ILE A 1 234 ? 219.944 232.505 217.767 1.00 86.91  ? 274 ILE A C   1 
ATOM 1489 O O   . ILE A 1 234 ? 219.164 233.283 218.329 1.00 91.03  ? 274 ILE A O   1 
ATOM 1490 C CB  . ILE A 1 234 ? 221.679 231.942 219.494 1.00 84.24  ? 274 ILE A CB  1 
ATOM 1491 C CG1 . ILE A 1 234 ? 223.165 231.998 219.834 1.00 87.55  ? 274 ILE A CG1 1 
ATOM 1492 C CG2 . ILE A 1 234 ? 221.167 230.515 219.566 1.00 88.95  ? 274 ILE A CG2 1 
ATOM 1493 C CD1 . ILE A 1 234 ? 223.974 230.960 219.139 1.00 88.17  ? 274 ILE A CD1 1 
ATOM 1494 N N   . LEU A 1 235 ? 219.545 231.613 216.864 1.00 90.20  ? 275 LEU A N   1 
ATOM 1495 C CA  . LEU A 1 235 ? 218.149 231.504 216.468 1.00 90.01  ? 275 LEU A CA  1 
ATOM 1496 C C   . LEU A 1 235 ? 217.691 230.059 216.580 1.00 94.31  ? 275 LEU A C   1 
ATOM 1497 O O   . LEU A 1 235 ? 218.337 229.155 216.040 1.00 98.68  ? 275 LEU A O   1 
ATOM 1498 C CB  . LEU A 1 235 ? 217.940 232.017 215.041 1.00 91.13  ? 275 LEU A CB  1 
ATOM 1499 C CG  . LEU A 1 235 ? 217.849 233.537 214.899 1.00 93.73  ? 275 LEU A CG  1 
ATOM 1500 C CD1 . LEU A 1 235 ? 219.219 234.132 214.634 1.00 93.77  ? 275 LEU A CD1 1 
ATOM 1501 C CD2 . LEU A 1 235 ? 216.875 233.917 213.800 1.00 95.53  ? 275 LEU A CD2 1 
ATOM 1502 N N   . GLY A 1 236 ? 216.578 229.850 217.280 1.00 94.73  ? 276 GLY A N   1 
ATOM 1503 C CA  . GLY A 1 236 ? 215.961 228.541 217.347 1.00 96.49  ? 276 GLY A CA  1 
ATOM 1504 C C   . GLY A 1 236 ? 216.804 227.527 218.102 1.00 92.55  ? 276 GLY A C   1 
ATOM 1505 O O   . GLY A 1 236 ? 217.605 227.862 218.978 1.00 93.26  ? 276 GLY A O   1 
ATOM 1506 N N   . GLY A 1 237 ? 216.612 226.261 217.746 1.00 88.67  ? 277 GLY A N   1 
ATOM 1507 C CA  . GLY A 1 237 ? 217.315 225.174 218.392 1.00 89.34  ? 277 GLY A CA  1 
ATOM 1508 C C   . GLY A 1 237 ? 216.604 224.680 219.633 1.00 93.22  ? 277 GLY A C   1 
ATOM 1509 O O   . GLY A 1 237 ? 215.560 225.187 220.050 1.00 99.52  ? 277 GLY A O   1 
ATOM 1510 N N   . GLY A 1 238 ? 217.192 223.659 220.233 1.00 91.97  ? 278 GLY A N   1 
ATOM 1511 C CA  . GLY A 1 238 ? 216.643 223.089 221.444 1.00 97.50  ? 278 GLY A CA  1 
ATOM 1512 C C   . GLY A 1 238 ? 217.141 221.675 221.646 1.00 102.37 ? 278 GLY A C   1 
ATOM 1513 O O   . GLY A 1 238 ? 217.896 221.132 220.840 1.00 100.95 ? 278 GLY A O   1 
ATOM 1514 N N   . THR A 1 239 ? 216.694 221.090 222.750 1.00 105.69 ? 279 THR A N   1 
ATOM 1515 C CA  . THR A 1 239 ? 217.041 219.720 223.088 1.00 101.95 ? 279 THR A CA  1 
ATOM 1516 C C   . THR A 1 239 ? 216.046 218.768 222.428 1.00 102.39 ? 279 THR A C   1 
ATOM 1517 O O   . THR A 1 239 ? 215.213 219.170 221.613 1.00 104.93 ? 279 THR A O   1 
ATOM 1518 C CB  . THR A 1 239 ? 217.071 219.536 224.603 1.00 104.64 ? 279 THR A CB  1 
ATOM 1519 O OG1 . THR A 1 239 ? 215.761 219.189 225.068 1.00 104.57 ? 279 THR A OG1 1 
ATOM 1520 C CG2 . THR A 1 239 ? 217.522 220.816 225.285 1.00 106.19 ? 279 THR A CG2 1 
ATOM 1521 N N   . SER A 1 240 ? 216.124 217.486 222.779 1.00 102.89 ? 280 SER A N   1 
ATOM 1522 C CA  . SER A 1 240 ? 215.173 216.511 222.268 1.00 104.06 ? 280 SER A CA  1 
ATOM 1523 C C   . SER A 1 240 ? 213.852 216.532 223.021 1.00 104.17 ? 280 SER A C   1 
ATOM 1524 O O   . SER A 1 240 ? 212.912 215.843 222.610 1.00 103.96 ? 280 SER A O   1 
ATOM 1525 C CB  . SER A 1 240 ? 215.774 215.106 222.329 1.00 106.99 ? 280 SER A CB  1 
ATOM 1526 O OG  . SER A 1 240 ? 215.440 214.466 223.547 1.00 111.01 ? 280 SER A OG  1 
ATOM 1527 N N   . TRP A 1 241 ? 213.758 217.299 224.105 1.00 105.77 ? 281 TRP A N   1 
ATOM 1528 C CA  . TRP A 1 241 ? 212.539 217.387 224.892 1.00 107.40 ? 281 TRP A CA  1 
ATOM 1529 C C   . TRP A 1 241 ? 211.932 218.782 224.906 1.00 104.88 ? 281 TRP A C   1 
ATOM 1530 O O   . TRP A 1 241 ? 210.881 218.974 225.529 1.00 105.67 ? 281 TRP A O   1 
ATOM 1531 C CB  . TRP A 1 241 ? 212.804 216.935 226.335 1.00 105.90 ? 281 TRP A CB  1 
ATOM 1532 N N   . THR A 1 242 ? 212.552 219.757 224.246 1.00 104.79 ? 282 THR A N   1 
ATOM 1533 C CA  . THR A 1 242 ? 212.023 221.112 224.240 1.00 107.11 ? 282 THR A CA  1 
ATOM 1534 C C   . THR A 1 242 ? 212.547 221.856 223.022 1.00 108.55 ? 282 THR A C   1 
ATOM 1535 O O   . THR A 1 242 ? 213.548 221.468 222.414 1.00 110.51 ? 282 THR A O   1 
ATOM 1536 C CB  . THR A 1 242 ? 212.394 221.868 225.520 1.00 107.80 ? 282 THR A CB  1 
ATOM 1537 O OG1 . THR A 1 242 ? 211.894 223.208 225.447 1.00 107.16 ? 282 THR A OG1 1 
ATOM 1538 C CG2 . THR A 1 242 ? 213.903 221.907 225.694 1.00 105.21 ? 282 THR A CG2 1 
ATOM 1539 N N   . ALA A 1 243 ? 211.848 222.933 222.676 1.00 106.27 ? 283 ALA A N   1 
ATOM 1540 C CA  . ALA A 1 243 ? 212.263 223.852 221.625 1.00 101.82 ? 283 ALA A CA  1 
ATOM 1541 C C   . ALA A 1 243 ? 212.223 225.264 222.185 1.00 99.62  ? 283 ALA A C   1 
ATOM 1542 O O   . ALA A 1 243 ? 211.220 225.669 222.782 1.00 99.20  ? 283 ALA A O   1 
ATOM 1543 C CB  . ALA A 1 243 ? 211.363 223.736 220.392 1.00 95.63  ? 283 ALA A CB  1 
ATOM 1544 N N   . TYR A 1 244 ? 213.306 226.009 221.992 1.00 97.11  ? 284 TYR A N   1 
ATOM 1545 C CA  . TYR A 1 244 ? 213.439 227.316 222.616 1.00 94.63  ? 284 TYR A CA  1 
ATOM 1546 C C   . TYR A 1 244 ? 212.727 228.386 221.801 1.00 96.09  ? 284 TYR A C   1 
ATOM 1547 O O   . TYR A 1 244 ? 212.708 228.343 220.568 1.00 94.09  ? 284 TYR A O   1 
ATOM 1548 C CB  . TYR A 1 244 ? 214.914 227.671 222.788 1.00 96.66  ? 284 TYR A CB  1 
ATOM 1549 C CG  . TYR A 1 244 ? 215.643 226.719 223.707 1.00 102.23 ? 284 TYR A CG  1 
ATOM 1550 C CD1 . TYR A 1 244 ? 215.115 226.381 224.945 1.00 105.48 ? 284 TYR A CD1 1 
ATOM 1551 C CD2 . TYR A 1 244 ? 216.852 226.149 223.335 1.00 100.37 ? 284 TYR A CD2 1 
ATOM 1552 C CE1 . TYR A 1 244 ? 215.772 225.508 225.787 1.00 104.43 ? 284 TYR A CE1 1 
ATOM 1553 C CE2 . TYR A 1 244 ? 217.515 225.275 224.171 1.00 101.69 ? 284 TYR A CE2 1 
ATOM 1554 C CZ  . TYR A 1 244 ? 216.971 224.959 225.395 1.00 104.94 ? 284 TYR A CZ  1 
ATOM 1555 O OH  . TYR A 1 244 ? 217.629 224.089 226.231 1.00 109.01 ? 284 TYR A OH  1 
ATOM 1556 N N   . SER A 1 245 ? 212.137 229.348 222.504 1.00 100.29 ? 285 SER A N   1 
ATOM 1557 C CA  . SER A 1 245 ? 211.377 230.406 221.857 1.00 101.81 ? 285 SER A CA  1 
ATOM 1558 C C   . SER A 1 245 ? 212.296 231.340 221.081 1.00 97.08  ? 285 SER A C   1 
ATOM 1559 O O   . SER A 1 245 ? 213.473 231.509 221.409 1.00 96.62  ? 285 SER A O   1 
ATOM 1560 C CB  . SER A 1 245 ? 210.585 231.202 222.893 1.00 100.81 ? 285 SER A CB  1 
ATOM 1561 O OG  . SER A 1 245 ? 210.132 232.430 222.352 1.00 104.76 ? 285 SER A OG  1 
ATOM 1562 N N   . LEU A 1 246 ? 211.742 231.951 220.037 1.00 92.78  ? 286 LEU A N   1 
ATOM 1563 C CA  . LEU A 1 246 ? 212.474 232.885 219.196 1.00 87.75  ? 286 LEU A CA  1 
ATOM 1564 C C   . LEU A 1 246 ? 212.127 234.338 219.488 1.00 93.26  ? 286 LEU A C   1 
ATOM 1565 O O   . LEU A 1 246 ? 212.583 235.229 218.766 1.00 97.34  ? 286 LEU A O   1 
ATOM 1566 C CB  . LEU A 1 246 ? 212.220 232.573 217.721 1.00 88.37  ? 286 LEU A CB  1 
ATOM 1567 C CG  . LEU A 1 246 ? 213.239 231.649 217.055 1.00 90.88  ? 286 LEU A CG  1 
ATOM 1568 C CD1 . LEU A 1 246 ? 212.612 230.912 215.887 1.00 92.04  ? 286 LEU A CD1 1 
ATOM 1569 C CD2 . LEU A 1 246 ? 214.453 232.438 216.603 1.00 92.43  ? 286 LEU A CD2 1 
ATOM 1570 N N   . ASN A 1 247 ? 211.333 234.602 220.526 1.00 91.99  ? 287 ASN A N   1 
ATOM 1571 C CA  . ASN A 1 247 ? 211.007 235.975 220.885 1.00 90.93  ? 287 ASN A CA  1 
ATOM 1572 C C   . ASN A 1 247 ? 212.131 236.667 221.643 1.00 92.57  ? 287 ASN A C   1 
ATOM 1573 O O   . ASN A 1 247 ? 212.078 237.888 221.819 1.00 94.86  ? 287 ASN A O   1 
ATOM 1574 C CB  . ASN A 1 247 ? 209.725 236.016 221.718 1.00 91.18  ? 287 ASN A CB  1 
ATOM 1575 C CG  . ASN A 1 247 ? 209.964 235.666 223.170 1.00 98.03  ? 287 ASN A CG  1 
ATOM 1576 O OD1 . ASN A 1 247 ? 210.164 234.503 223.515 1.00 102.01 ? 287 ASN A OD1 1 
ATOM 1577 N ND2 . ASN A 1 247 ? 209.944 236.675 224.032 1.00 99.42  ? 287 ASN A ND2 1 
ATOM 1578 N N   . LYS A 1 248 ? 213.135 235.921 222.096 1.00 92.13  ? 288 LYS A N   1 
ATOM 1579 C CA  . LYS A 1 248 ? 214.327 236.483 222.714 1.00 91.53  ? 288 LYS A CA  1 
ATOM 1580 C C   . LYS A 1 248 ? 215.543 235.818 222.092 1.00 93.45  ? 288 LYS A C   1 
ATOM 1581 O O   . LYS A 1 248 ? 215.576 234.592 221.947 1.00 100.01 ? 288 LYS A O   1 
ATOM 1582 C CB  . LYS A 1 248 ? 214.321 236.281 224.230 1.00 93.27  ? 288 LYS A CB  1 
ATOM 1583 C CG  . LYS A 1 248 ? 214.006 237.539 225.018 1.00 94.68  ? 288 LYS A CG  1 
ATOM 1584 C CD  . LYS A 1 248 ? 214.247 237.329 226.502 1.00 100.85 ? 288 LYS A CD  1 
ATOM 1585 C CE  . LYS A 1 248 ? 213.656 238.460 227.324 1.00 100.76 ? 288 LYS A CE  1 
ATOM 1586 N NZ  . LYS A 1 248 ? 213.577 239.725 226.547 1.00 101.83 ? 288 LYS A NZ  1 
ATOM 1587 N N   . ILE A 1 249 ? 216.538 236.620 221.731 1.00 91.73  ? 289 ILE A N   1 
ATOM 1588 C CA  . ILE A 1 249 ? 217.695 236.154 220.979 1.00 89.20  ? 289 ILE A CA  1 
ATOM 1589 C C   . ILE A 1 249 ? 218.950 236.440 221.788 1.00 96.50  ? 289 ILE A C   1 
ATOM 1590 O O   . ILE A 1 249 ? 219.137 237.559 222.280 1.00 100.80 ? 289 ILE A O   1 
ATOM 1591 C CB  . ILE A 1 249 ? 217.768 236.822 219.595 1.00 89.24  ? 289 ILE A CB  1 
ATOM 1592 C CG1 . ILE A 1 249 ? 216.732 236.206 218.657 1.00 85.94  ? 289 ILE A CG1 1 
ATOM 1593 C CG2 . ILE A 1 249 ? 219.162 236.698 219.009 1.00 93.41  ? 289 ILE A CG2 1 
ATOM 1594 C CD1 . ILE A 1 249 ? 216.705 236.837 217.290 1.00 87.52  ? 289 ILE A CD1 1 
ATOM 1595 N N   . HIS A 1 250 ? 219.803 235.431 221.928 1.00 95.40  ? 290 HIS A N   1 
ATOM 1596 C CA  . HIS A 1 250 ? 221.088 235.593 222.592 1.00 94.53  ? 290 HIS A CA  1 
ATOM 1597 C C   . HIS A 1 250 ? 222.126 236.012 221.560 1.00 92.91  ? 290 HIS A C   1 
ATOM 1598 O O   . HIS A 1 250 ? 222.323 235.325 220.552 1.00 94.36  ? 290 HIS A O   1 
ATOM 1599 C CB  . HIS A 1 250 ? 221.508 234.301 223.289 1.00 94.91  ? 290 HIS A CB  1 
ATOM 1600 C CG  . HIS A 1 250 ? 220.636 233.931 224.447 1.00 102.80 ? 290 HIS A CG  1 
ATOM 1601 N ND1 . HIS A 1 250 ? 219.372 233.406 224.290 1.00 107.97 ? 290 HIS A ND1 1 
ATOM 1602 C CD2 . HIS A 1 250 ? 220.845 234.014 225.782 1.00 105.77 ? 290 HIS A CD2 1 
ATOM 1603 C CE1 . HIS A 1 250 ? 218.841 233.179 225.477 1.00 111.35 ? 290 HIS A CE1 1 
ATOM 1604 N NE2 . HIS A 1 250 ? 219.714 233.540 226.400 1.00 110.10 ? 290 HIS A NE2 1 
ATOM 1605 N N   . ALA A 1 251 ? 222.787 237.137 221.812 1.00 93.79  ? 291 ALA A N   1 
ATOM 1606 C CA  . ALA A 1 251 ? 223.811 237.664 220.924 1.00 92.60  ? 291 ALA A CA  1 
ATOM 1607 C C   . ALA A 1 251 ? 225.125 237.777 221.679 1.00 95.18  ? 291 ALA A C   1 
ATOM 1608 O O   . ALA A 1 251 ? 225.182 238.388 222.750 1.00 99.30  ? 291 ALA A O   1 
ATOM 1609 C CB  . ALA A 1 251 ? 223.405 239.027 220.361 1.00 96.90  ? 291 ALA A CB  1 
ATOM 1610 N N   . TYR A 1 252 ? 226.172 237.191 221.117 1.00 92.28  ? 292 TYR A N   1 
ATOM 1611 C CA  . TYR A 1 252 ? 227.513 237.301 221.670 1.00 97.30  ? 292 TYR A CA  1 
ATOM 1612 C C   . TYR A 1 252 ? 228.246 238.443 220.984 1.00 101.96 ? 292 TYR A C   1 
ATOM 1613 O O   . TYR A 1 252 ? 228.270 238.520 219.752 1.00 103.66 ? 292 TYR A O   1 
ATOM 1614 C CB  . TYR A 1 252 ? 228.284 235.995 221.489 1.00 96.73  ? 292 TYR A CB  1 
ATOM 1615 C CG  . TYR A 1 252 ? 229.729 236.082 221.917 1.00 99.10  ? 292 TYR A CG  1 
ATOM 1616 C CD1 . TYR A 1 252 ? 230.091 235.881 223.240 1.00 100.83 ? 292 TYR A CD1 1 
ATOM 1617 C CD2 . TYR A 1 252 ? 230.729 236.368 221.000 1.00 98.22  ? 292 TYR A CD2 1 
ATOM 1618 C CE1 . TYR A 1 252 ? 231.409 235.959 223.638 1.00 102.38 ? 292 TYR A CE1 1 
ATOM 1619 C CE2 . TYR A 1 252 ? 232.049 236.448 221.389 1.00 101.85 ? 292 TYR A CE2 1 
ATOM 1620 C CZ  . TYR A 1 252 ? 232.383 236.242 222.709 1.00 104.39 ? 292 TYR A CZ  1 
ATOM 1621 O OH  . TYR A 1 252 ? 233.697 236.321 223.100 1.00 106.20 ? 292 TYR A OH  1 
ATOM 1622 N N   . ASN A 1 253 ? 228.845 239.321 221.783 1.00 100.27 ? 293 ASN A N   1 
ATOM 1623 C CA  . ASN A 1 253 ? 229.554 240.490 221.281 1.00 99.13  ? 293 ASN A CA  1 
ATOM 1624 C C   . ASN A 1 253 ? 231.042 240.172 221.205 1.00 103.31 ? 293 ASN A C   1 
ATOM 1625 O O   . ASN A 1 253 ? 231.660 239.832 222.218 1.00 105.46 ? 293 ASN A O   1 
ATOM 1626 C CB  . ASN A 1 253 ? 229.303 241.698 222.182 1.00 98.79  ? 293 ASN A CB  1 
ATOM 1627 C CG  . ASN A 1 253 ? 229.882 242.977 221.618 1.00 102.32 ? 293 ASN A CG  1 
ATOM 1628 O OD1 . ASN A 1 253 ? 231.099 243.148 221.556 1.00 103.31 ? 293 ASN A OD1 1 
ATOM 1629 N ND2 . ASN A 1 253 ? 229.009 243.886 221.204 1.00 105.44 ? 293 ASN A ND2 1 
ATOM 1630 N N   . LEU A 1 254 ? 231.610 240.281 220.002 1.00 102.84 ? 294 LEU A N   1 
ATOM 1631 C CA  . LEU A 1 254 ? 233.027 239.982 219.824 1.00 102.06 ? 294 LEU A CA  1 
ATOM 1632 C C   . LEU A 1 254 ? 233.907 240.993 220.549 1.00 106.01 ? 294 LEU A C   1 
ATOM 1633 O O   . LEU A 1 254 ? 234.911 240.621 221.166 1.00 105.38 ? 294 LEU A O   1 
ATOM 1634 C CB  . LEU A 1 254 ? 233.377 239.945 218.337 1.00 101.60 ? 294 LEU A CB  1 
ATOM 1635 C CG  . LEU A 1 254 ? 232.992 238.702 217.530 1.00 102.15 ? 294 LEU A CG  1 
ATOM 1636 C CD1 . LEU A 1 254 ? 233.460 237.441 218.238 1.00 99.71  ? 294 LEU A CD1 1 
ATOM 1637 C CD2 . LEU A 1 254 ? 231.500 238.648 217.244 1.00 100.63 ? 294 LEU A CD2 1 
ATOM 1638 N N   . GLU A 1 255 ? 233.551 242.277 220.480 1.00 107.15 ? 295 GLU A N   1 
ATOM 1639 C CA  . GLU A 1 255 ? 234.393 243.314 221.069 1.00 104.63 ? 295 GLU A CA  1 
ATOM 1640 C C   . GLU A 1 255 ? 234.391 243.234 222.591 1.00 103.09 ? 295 GLU A C   1 
ATOM 1641 O O   . GLU A 1 255 ? 235.452 243.259 223.224 1.00 100.80 ? 295 GLU A O   1 
ATOM 1642 C CB  . GLU A 1 255 ? 233.929 244.693 220.602 1.00 100.84 ? 295 GLU A CB  1 
ATOM 1643 N N   . THR A 1 256 ? 233.208 243.137 223.196 1.00 104.58 ? 296 THR A N   1 
ATOM 1644 C CA  . THR A 1 256 ? 233.106 243.106 224.649 1.00 106.72 ? 296 THR A CA  1 
ATOM 1645 C C   . THR A 1 256 ? 233.291 241.713 225.234 1.00 108.29 ? 296 THR A C   1 
ATOM 1646 O O   . THR A 1 256 ? 233.460 241.594 226.452 1.00 110.79 ? 296 THR A O   1 
ATOM 1647 C CB  . THR A 1 256 ? 231.754 243.668 225.096 1.00 107.51 ? 296 THR A CB  1 
ATOM 1648 O OG1 . THR A 1 256 ? 230.734 242.684 224.893 1.00 109.10 ? 296 THR A OG1 1 
ATOM 1649 C CG2 . THR A 1 256 ? 231.410 244.917 224.304 1.00 107.68 ? 296 THR A CG2 1 
ATOM 1650 N N   . ASN A 1 257 ? 233.268 240.668 224.404 1.00 105.82 ? 297 ASN A N   1 
ATOM 1651 C CA  . ASN A 1 257 ? 233.462 239.289 224.854 1.00 104.35 ? 297 ASN A CA  1 
ATOM 1652 C C   . ASN A 1 257 ? 232.463 238.915 225.950 1.00 105.51 ? 297 ASN A C   1 
ATOM 1653 O O   . ASN A 1 257 ? 232.830 238.411 227.013 1.00 106.25 ? 297 ASN A O   1 
ATOM 1654 C CB  . ASN A 1 257 ? 234.901 239.065 225.324 1.00 104.64 ? 297 ASN A CB  1 
ATOM 1655 C CG  . ASN A 1 257 ? 235.275 237.599 225.375 1.00 107.26 ? 297 ASN A CG  1 
ATOM 1656 O OD1 . ASN A 1 257 ? 235.418 236.949 224.341 1.00 106.36 ? 297 ASN A OD1 1 
ATOM 1657 N ND2 . ASN A 1 257 ? 235.433 237.070 226.581 1.00 106.32 ? 297 ASN A ND2 1 
ATOM 1658 N N   . ALA A 1 258 ? 231.185 239.174 225.685 1.00 104.20 ? 298 ALA A N   1 
ATOM 1659 C CA  . ALA A 1 258 ? 230.133 238.848 226.635 1.00 99.33  ? 298 ALA A CA  1 
ATOM 1660 C C   . ALA A 1 258 ? 228.824 238.648 225.887 1.00 99.93  ? 298 ALA A C   1 
ATOM 1661 O O   . ALA A 1 258 ? 228.620 239.186 224.796 1.00 104.46 ? 298 ALA A O   1 
ATOM 1662 C CB  . ALA A 1 258 ? 229.978 239.938 227.701 1.00 97.56  ? 298 ALA A CB  1 
ATOM 1663 N N   . TRP A 1 259 ? 227.935 237.868 226.491 1.00 98.02  ? 299 TRP A N   1 
ATOM 1664 C CA  . TRP A 1 259 ? 226.637 237.579 225.905 1.00 99.07  ? 299 TRP A CA  1 
ATOM 1665 C C   . TRP A 1 259 ? 225.611 238.616 226.342 1.00 100.61 ? 299 TRP A C   1 
ATOM 1666 O O   . TRP A 1 259 ? 225.763 239.271 227.376 1.00 102.36 ? 299 TRP A O   1 
ATOM 1667 C CB  . TRP A 1 259 ? 226.161 236.182 226.303 1.00 101.54 ? 299 TRP A CB  1 
ATOM 1668 C CG  . TRP A 1 259 ? 227.024 235.076 225.782 1.00 98.79  ? 299 TRP A CG  1 
ATOM 1669 C CD1 . TRP A 1 259 ? 228.215 234.658 226.295 1.00 98.32  ? 299 TRP A CD1 1 
ATOM 1670 C CD2 . TRP A 1 259 ? 226.761 234.243 224.648 1.00 97.28  ? 299 TRP A CD2 1 
ATOM 1671 N NE1 . TRP A 1 259 ? 228.712 233.617 225.551 1.00 93.88  ? 299 TRP A NE1 1 
ATOM 1672 C CE2 . TRP A 1 259 ? 227.837 233.343 224.533 1.00 95.66  ? 299 TRP A CE2 1 
ATOM 1673 C CE3 . TRP A 1 259 ? 225.720 234.171 223.718 1.00 98.68  ? 299 TRP A CE3 1 
ATOM 1674 C CZ2 . TRP A 1 259 ? 227.903 232.384 223.527 1.00 96.41  ? 299 TRP A CZ2 1 
ATOM 1675 C CZ3 . TRP A 1 259 ? 225.788 233.219 222.720 1.00 96.55  ? 299 TRP A CZ3 1 
ATOM 1676 C CH2 . TRP A 1 259 ? 226.871 232.338 222.632 1.00 94.87  ? 299 TRP A CH2 1 
ATOM 1677 N N   . GLU A 1 260 ? 224.558 238.756 225.541 1.00 100.21 ? 300 GLU A N   1 
ATOM 1678 C CA  . GLU A 1 260 ? 223.474 239.679 225.834 1.00 99.60  ? 300 GLU A CA  1 
ATOM 1679 C C   . GLU A 1 260 ? 222.174 239.100 225.301 1.00 99.89  ? 300 GLU A C   1 
ATOM 1680 O O   . GLU A 1 260 ? 222.168 238.240 224.418 1.00 101.92 ? 300 GLU A O   1 
ATOM 1681 C CB  . GLU A 1 260 ? 223.728 241.064 225.226 1.00 93.09  ? 300 GLU A CB  1 
ATOM 1682 N N   . GLU A 1 261 ? 221.066 239.584 225.851 1.00 99.58  ? 301 GLU A N   1 
ATOM 1683 C CA  . GLU A 1 261 ? 219.734 239.136 225.471 1.00 99.69  ? 301 GLU A CA  1 
ATOM 1684 C C   . GLU A 1 261 ? 218.997 240.282 224.796 1.00 97.14  ? 301 GLU A C   1 
ATOM 1685 O O   . GLU A 1 261 ? 218.999 241.409 225.302 1.00 101.60 ? 301 GLU A O   1 
ATOM 1686 C CB  . GLU A 1 261 ? 218.956 238.648 226.693 1.00 101.74 ? 301 GLU A CB  1 
ATOM 1687 C CG  . GLU A 1 261 ? 217.942 237.562 226.392 1.00 102.10 ? 301 GLU A CG  1 
ATOM 1688 C CD  . GLU A 1 261 ? 217.796 236.578 227.533 1.00 106.64 ? 301 GLU A CD  1 
ATOM 1689 O OE1 . GLU A 1 261 ? 217.878 237.007 228.702 1.00 107.60 ? 301 GLU A OE1 1 
ATOM 1690 O OE2 . GLU A 1 261 ? 217.599 235.376 227.262 1.00 108.04 ? 301 GLU A OE2 1 
ATOM 1691 N N   . ILE A 1 262 ? 218.371 239.997 223.657 1.00 94.01  ? 302 ILE A N   1 
ATOM 1692 C CA  . ILE A 1 262 ? 217.662 240.998 222.871 1.00 92.51  ? 302 ILE A CA  1 
ATOM 1693 C C   . ILE A 1 262 ? 216.220 240.548 222.705 1.00 97.05  ? 302 ILE A C   1 
ATOM 1694 O O   . ILE A 1 262 ? 215.963 239.397 222.335 1.00 102.47 ? 302 ILE A O   1 
ATOM 1695 C CB  . ILE A 1 262 ? 218.323 241.212 221.499 1.00 91.80  ? 302 ILE A CB  1 
ATOM 1696 C CG1 . ILE A 1 262 ? 219.846 241.273 221.647 1.00 94.55  ? 302 ILE A CG1 1 
ATOM 1697 C CG2 . ILE A 1 262 ? 217.771 242.464 220.839 1.00 96.66  ? 302 ILE A CG2 1 
ATOM 1698 C CD1 . ILE A 1 262 ? 220.555 241.936 220.490 1.00 98.70  ? 302 ILE A CD1 1 
ATOM 1699 N N   . ALA A 1 263 ? 215.284 241.452 222.976 1.00 97.63  ? 303 ALA A N   1 
ATOM 1700 C CA  . ALA A 1 263 ? 213.859 241.175 222.845 1.00 98.85  ? 303 ALA A CA  1 
ATOM 1701 C C   . ALA A 1 263 ? 213.384 241.698 221.495 1.00 96.64  ? 303 ALA A C   1 
ATOM 1702 O O   . ALA A 1 263 ? 213.195 242.906 221.321 1.00 101.50 ? 303 ALA A O   1 
ATOM 1703 C CB  . ALA A 1 263 ? 213.073 241.811 223.988 1.00 103.55 ? 303 ALA A CB  1 
ATOM 1704 N N   . THR A 1 264 ? 213.194 240.790 220.543 1.00 93.05  ? 304 THR A N   1 
ATOM 1705 C CA  . THR A 1 264 ? 212.729 241.181 219.222 1.00 91.18  ? 304 THR A CA  1 
ATOM 1706 C C   . THR A 1 264 ? 211.284 241.659 219.283 1.00 90.24  ? 304 THR A C   1 
ATOM 1707 O O   . THR A 1 264 ? 210.480 241.180 220.086 1.00 90.91  ? 304 THR A O   1 
ATOM 1708 C CB  . THR A 1 264 ? 212.845 240.015 218.243 1.00 93.37  ? 304 THR A CB  1 
ATOM 1709 O OG1 . THR A 1 264 ? 212.007 238.939 218.680 1.00 95.69  ? 304 THR A OG1 1 
ATOM 1710 C CG2 . THR A 1 264 ? 214.280 239.529 218.166 1.00 95.43  ? 304 THR A CG2 1 
ATOM 1711 N N   . LYS A 1 265 ? 210.964 242.621 218.431 1.00 90.89  ? 305 LYS A N   1 
ATOM 1712 C CA  . LYS A 1 265 ? 209.598 243.105 218.357 1.00 90.45  ? 305 LYS A CA  1 
ATOM 1713 C C   . LYS A 1 265 ? 208.725 242.118 217.584 1.00 88.46  ? 305 LYS A C   1 
ATOM 1714 O O   . LYS A 1 265 ? 209.204 241.433 216.677 1.00 89.98  ? 305 LYS A O   1 
ATOM 1715 C CB  . LYS A 1 265 ? 209.554 244.474 217.691 1.00 91.50  ? 305 LYS A CB  1 
ATOM 1716 C CG  . LYS A 1 265 ? 209.452 245.626 218.672 1.00 88.66  ? 305 LYS A CG  1 
ATOM 1717 C CD  . LYS A 1 265 ? 210.079 246.885 218.107 1.00 92.54  ? 305 LYS A CD  1 
ATOM 1718 C CE  . LYS A 1 265 ? 211.568 246.705 217.896 1.00 93.93  ? 305 LYS A CE  1 
ATOM 1719 N NZ  . LYS A 1 265 ? 212.278 246.457 219.178 1.00 95.40  ? 305 LYS A NZ  1 
ATOM 1720 N N   . PRO A 1 266 ? 207.443 242.027 217.923 1.00 88.06  ? 306 PRO A N   1 
ATOM 1721 C CA  . PRO A 1 266 ? 206.573 241.060 217.245 1.00 92.64  ? 306 PRO A CA  1 
ATOM 1722 C C   . PRO A 1 266 ? 205.952 241.620 215.978 1.00 96.29  ? 306 PRO A C   1 
ATOM 1723 O O   . PRO A 1 266 ? 206.181 242.780 215.624 1.00 99.19  ? 306 PRO A O   1 
ATOM 1724 C CB  . PRO A 1 266 ? 205.500 240.754 218.299 1.00 96.59  ? 306 PRO A CB  1 
ATOM 1725 C CG  . PRO A 1 266 ? 205.612 241.857 219.341 1.00 99.36  ? 306 PRO A CG  1 
ATOM 1726 C CD  . PRO A 1 266 ? 206.716 242.791 218.946 1.00 93.20  ? 306 PRO A CD  1 
ATOM 1727 N N   . HIS A 1 267 ? 205.162 240.800 215.291 1.00 97.89  ? 307 HIS A N   1 
ATOM 1728 C CA  . HIS A 1 267 ? 204.435 241.263 214.122 1.00 97.86  ? 307 HIS A CA  1 
ATOM 1729 C C   . HIS A 1 267 ? 203.294 242.185 214.546 1.00 101.26 ? 307 HIS A C   1 
ATOM 1730 O O   . HIS A 1 267 ? 203.002 242.359 215.732 1.00 100.99 ? 307 HIS A O   1 
ATOM 1731 C CB  . HIS A 1 267 ? 203.896 240.078 213.322 1.00 98.67  ? 307 HIS A CB  1 
ATOM 1732 C CG  . HIS A 1 267 ? 203.795 240.337 211.851 1.00 101.35 ? 307 HIS A CG  1 
ATOM 1733 N ND1 . HIS A 1 267 ? 202.669 240.871 211.264 1.00 102.68 ? 307 HIS A ND1 1 
ATOM 1734 C CD2 . HIS A 1 267 ? 204.680 240.131 210.847 1.00 99.78  ? 307 HIS A CD2 1 
ATOM 1735 C CE1 . HIS A 1 267 ? 202.864 240.985 209.963 1.00 97.89  ? 307 HIS A CE1 1 
ATOM 1736 N NE2 . HIS A 1 267 ? 204.077 240.543 209.684 1.00 96.25  ? 307 HIS A NE2 1 
ATOM 1737 N N   . GLU A 1 268 ? 202.645 242.790 213.550 1.00 104.69 ? 308 GLU A N   1 
ATOM 1738 C CA  . GLU A 1 268 ? 201.543 243.702 213.835 1.00 106.94 ? 308 GLU A CA  1 
ATOM 1739 C C   . GLU A 1 268 ? 200.376 242.968 214.484 1.00 108.73 ? 308 GLU A C   1 
ATOM 1740 O O   . GLU A 1 268 ? 199.864 243.395 215.525 1.00 106.71 ? 308 GLU A O   1 
ATOM 1741 C CB  . GLU A 1 268 ? 201.096 244.400 212.552 1.00 104.89 ? 308 GLU A CB  1 
ATOM 1742 N N   . LYS A 1 269 ? 199.941 241.857 213.883 1.00 109.00 ? 309 LYS A N   1 
ATOM 1743 C CA  . LYS A 1 269 ? 198.824 241.100 214.434 1.00 109.97 ? 309 LYS A CA  1 
ATOM 1744 C C   . LYS A 1 269 ? 199.037 239.593 214.336 1.00 109.90 ? 309 LYS A C   1 
ATOM 1745 O O   . LYS A 1 269 ? 198.073 238.831 214.474 1.00 110.00 ? 309 LYS A O   1 
ATOM 1746 C CB  . LYS A 1 269 ? 197.526 241.485 213.724 1.00 30.00  ? 309 LYS A CB  1 
ATOM 1747 N N   . ILE A 1 270 ? 200.267 239.141 214.100 1.00 106.91 ? 310 ILE A N   1 
ATOM 1748 C CA  . ILE A 1 270 ? 200.547 237.722 213.969 1.00 104.86 ? 310 ILE A CA  1 
ATOM 1749 C C   . ILE A 1 270 ? 201.271 237.152 215.185 1.00 107.37 ? 310 ILE A C   1 
ATOM 1750 O O   . ILE A 1 270 ? 201.057 235.982 215.522 1.00 110.12 ? 310 ILE A O   1 
ATOM 1751 C CB  . ILE A 1 270 ? 201.345 237.438 212.680 1.00 97.97  ? 310 ILE A CB  1 
ATOM 1752 N N   . GLY A 1 271 ? 202.113 237.934 215.850 1.00 105.57 ? 311 GLY A N   1 
ATOM 1753 C CA  . GLY A 1 271 ? 202.869 237.457 216.992 1.00 99.80  ? 311 GLY A CA  1 
ATOM 1754 C C   . GLY A 1 271 ? 204.256 236.989 216.599 1.00 96.69  ? 311 GLY A C   1 
ATOM 1755 O O   . GLY A 1 271 ? 204.697 237.107 215.452 1.00 100.29 ? 311 GLY A O   1 
ATOM 1756 N N   . PHE A 1 272 ? 204.956 236.448 217.591 1.00 90.97  ? 312 PHE A N   1 
ATOM 1757 C CA  . PHE A 1 272 ? 206.301 235.950 217.376 1.00 92.16  ? 312 PHE A CA  1 
ATOM 1758 C C   . PHE A 1 272 ? 206.266 234.630 216.610 1.00 96.49  ? 312 PHE A C   1 
ATOM 1759 O O   . PHE A 1 272 ? 205.257 233.923 216.619 1.00 101.16 ? 312 PHE A O   1 
ATOM 1760 C CB  . PHE A 1 272 ? 207.014 235.758 218.710 1.00 92.71  ? 312 PHE A CB  1 
ATOM 1761 C CG  . PHE A 1 272 ? 207.108 237.007 219.529 1.00 95.18  ? 312 PHE A CG  1 
ATOM 1762 C CD1 . PHE A 1 272 ? 208.056 237.969 219.238 1.00 93.80  ? 312 PHE A CD1 1 
ATOM 1763 C CD2 . PHE A 1 272 ? 206.249 237.218 220.592 1.00 100.21 ? 312 PHE A CD2 1 
ATOM 1764 C CE1 . PHE A 1 272 ? 208.145 239.119 219.992 1.00 97.07  ? 312 PHE A CE1 1 
ATOM 1765 C CE2 . PHE A 1 272 ? 206.333 238.367 221.350 1.00 101.37 ? 312 PHE A CE2 1 
ATOM 1766 C CZ  . PHE A 1 272 ? 207.283 239.318 221.050 1.00 100.89 ? 312 PHE A CZ  1 
ATOM 1767 N N   . PRO A 1 273 ? 207.357 234.283 215.926 1.00 93.27  ? 313 PRO A N   1 
ATOM 1768 C CA  . PRO A 1 273 ? 207.437 232.958 215.303 1.00 89.73  ? 313 PRO A CA  1 
ATOM 1769 C C   . PRO A 1 273 ? 207.349 231.861 216.352 1.00 96.23  ? 313 PRO A C   1 
ATOM 1770 O O   . PRO A 1 273 ? 207.857 232.000 217.466 1.00 94.59  ? 313 PRO A O   1 
ATOM 1771 C CB  . PRO A 1 273 ? 208.806 232.969 214.615 1.00 87.00  ? 313 PRO A CB  1 
ATOM 1772 C CG  . PRO A 1 273 ? 209.137 234.404 214.444 1.00 89.80  ? 313 PRO A CG  1 
ATOM 1773 C CD  . PRO A 1 273 ? 208.531 235.113 215.611 1.00 92.46  ? 313 PRO A CD  1 
ATOM 1774 N N   . ALA A 1 274 ? 206.690 230.765 215.986 1.00 99.55  ? 314 ALA A N   1 
ATOM 1775 C CA  . ALA A 1 274 ? 206.545 229.647 216.906 1.00 100.53 ? 314 ALA A CA  1 
ATOM 1776 C C   . ALA A 1 274 ? 207.905 229.038 217.219 1.00 98.20  ? 314 ALA A C   1 
ATOM 1777 O O   . ALA A 1 274 ? 208.784 228.966 216.357 1.00 96.96  ? 314 ALA A O   1 
ATOM 1778 C CB  . ALA A 1 274 ? 205.615 228.589 216.314 1.00 93.69  ? 314 ALA A CB  1 
ATOM 1779 N N   . ALA A 1 275 ? 208.079 228.613 218.469 1.00 94.79  ? 315 ALA A N   1 
ATOM 1780 C CA  . ALA A 1 275 ? 209.326 227.979 218.871 1.00 91.54  ? 315 ALA A CA  1 
ATOM 1781 C C   . ALA A 1 275 ? 209.554 226.717 218.051 1.00 93.75  ? 315 ALA A C   1 
ATOM 1782 O O   . ALA A 1 275 ? 208.650 225.893 217.896 1.00 97.36  ? 315 ALA A O   1 
ATOM 1783 C CB  . ALA A 1 275 ? 209.297 227.649 220.362 1.00 89.03  ? 315 ALA A CB  1 
ATOM 1784 N N   . ARG A 1 276 ? 210.767 226.569 217.525 1.00 90.17  ? 316 ARG A N   1 
ATOM 1785 C CA  . ARG A 1 276 ? 211.054 225.486 216.600 1.00 84.01  ? 316 ARG A CA  1 
ATOM 1786 C C   . ARG A 1 276 ? 212.519 225.099 216.704 1.00 82.51  ? 316 ARG A C   1 
ATOM 1787 O O   . ARG A 1 276 ? 213.358 225.873 217.169 1.00 84.51  ? 316 ARG A O   1 
ATOM 1788 C CB  . ARG A 1 276 ? 210.718 225.882 215.160 1.00 83.89  ? 316 ARG A CB  1 
ATOM 1789 C CG  . ARG A 1 276 ? 211.614 226.977 214.611 1.00 84.85  ? 316 ARG A CG  1 
ATOM 1790 C CD  . ARG A 1 276 ? 211.092 227.517 213.296 1.00 83.17  ? 316 ARG A CD  1 
ATOM 1791 N NE  . ARG A 1 276 ? 209.718 227.989 213.411 1.00 85.36  ? 316 ARG A NE  1 
ATOM 1792 C CZ  . ARG A 1 276 ? 208.937 228.272 212.378 1.00 84.69  ? 316 ARG A CZ  1 
ATOM 1793 N NH1 . ARG A 1 276 ? 209.367 228.150 211.134 1.00 85.57  ? 316 ARG A NH1 1 
ATOM 1794 N NH2 . ARG A 1 276 ? 207.695 228.690 212.600 1.00 85.79  ? 316 ARG A NH2 1 
ATOM 1795 N N   . ARG A 1 277 ? 212.813 223.881 216.260 1.00 86.76  ? 317 ARG A N   1 
ATOM 1796 C CA  . ARG A 1 277 ? 214.178 223.396 216.145 1.00 90.02  ? 317 ARG A CA  1 
ATOM 1797 C C   . ARG A 1 277 ? 214.296 222.608 214.850 1.00 88.12  ? 317 ARG A C   1 
ATOM 1798 O O   . ARG A 1 277 ? 213.295 222.271 214.212 1.00 89.38  ? 317 ARG A O   1 
ATOM 1799 C CB  . ARG A 1 277 ? 214.583 222.542 217.352 1.00 91.78  ? 317 ARG A CB  1 
ATOM 1800 C CG  . ARG A 1 277 ? 214.004 221.144 217.345 1.00 94.16  ? 317 ARG A CG  1 
ATOM 1801 C CD  . ARG A 1 277 ? 214.782 220.226 218.269 1.00 97.47  ? 317 ARG A CD  1 
ATOM 1802 N NE  . ARG A 1 277 ? 214.139 218.926 218.408 1.00 99.90  ? 317 ARG A NE  1 
ATOM 1803 C CZ  . ARG A 1 277 ? 213.099 218.685 219.193 1.00 102.91 ? 317 ARG A CZ  1 
ATOM 1804 N NH1 . ARG A 1 277 ? 212.555 219.638 219.932 1.00 100.43 ? 317 ARG A NH1 1 
ATOM 1805 N NH2 . ARG A 1 277 ? 212.591 217.457 219.238 1.00 105.36 ? 317 ARG A NH2 1 
ATOM 1806 N N   . CYS A 1 278 ? 215.539 222.327 214.458 1.00 86.30  ? 318 CYS A N   1 
ATOM 1807 C CA  . CYS A 1 278 ? 215.841 221.668 213.188 1.00 89.53  ? 318 CYS A CA  1 
ATOM 1808 C C   . CYS A 1 278 ? 215.310 222.468 212.004 1.00 92.37  ? 318 CYS A C   1 
ATOM 1809 O O   . CYS A 1 278 ? 214.961 221.907 210.963 1.00 96.36  ? 318 CYS A O   1 
ATOM 1810 C CB  . CYS A 1 278 ? 215.302 220.236 213.156 1.00 89.39  ? 318 CYS A CB  1 
ATOM 1811 S SG  . CYS A 1 278 ? 215.570 219.322 214.686 1.00 103.95 ? 318 CYS A SG  1 
ATOM 1812 N N   . HIS A 1 279 ? 215.251 223.785 212.160 1.00 86.54  ? 319 HIS A N   1 
ATOM 1813 C CA  . HIS A 1 279 ? 214.781 224.676 211.110 1.00 83.28  ? 319 HIS A CA  1 
ATOM 1814 C C   . HIS A 1 279 ? 215.930 224.972 210.150 1.00 88.00  ? 319 HIS A C   1 
ATOM 1815 O O   . HIS A 1 279 ? 216.989 224.339 210.190 1.00 92.76  ? 319 HIS A O   1 
ATOM 1816 C CB  . HIS A 1 279 ? 214.207 225.951 211.720 1.00 84.47  ? 319 HIS A CB  1 
ATOM 1817 C CG  . HIS A 1 279 ? 215.187 226.717 212.552 1.00 88.83  ? 319 HIS A CG  1 
ATOM 1818 N ND1 . HIS A 1 279 ? 215.784 226.190 213.676 1.00 92.03  ? 319 HIS A ND1 1 
ATOM 1819 C CD2 . HIS A 1 279 ? 215.675 227.973 212.422 1.00 93.45  ? 319 HIS A CD2 1 
ATOM 1820 C CE1 . HIS A 1 279 ? 216.599 227.087 214.202 1.00 92.46  ? 319 HIS A CE1 1 
ATOM 1821 N NE2 . HIS A 1 279 ? 216.550 228.178 213.461 1.00 92.43  ? 319 HIS A NE2 1 
ATOM 1822 N N   . SER A 1 280 ? 215.729 225.944 209.267 1.00 87.86  ? 320 SER A N   1 
ATOM 1823 C CA  . SER A 1 280 ? 216.764 226.397 208.352 1.00 86.55  ? 320 SER A CA  1 
ATOM 1824 C C   . SER A 1 280 ? 216.847 227.913 208.408 1.00 85.54  ? 320 SER A C   1 
ATOM 1825 O O   . SER A 1 280 ? 215.850 228.592 208.659 1.00 88.03  ? 320 SER A O   1 
ATOM 1826 C CB  . SER A 1 280 ? 216.486 225.941 206.921 1.00 86.28  ? 320 SER A CB  1 
ATOM 1827 O OG  . SER A 1 280 ? 215.559 226.804 206.289 1.00 86.12  ? 320 SER A OG  1 
ATOM 1828 N N   . CYS A 1 281 ? 218.044 228.442 208.177 1.00 85.75  ? 321 CYS A N   1 
ATOM 1829 C CA  . CYS A 1 281 ? 218.260 229.878 208.246 1.00 89.51  ? 321 CYS A CA  1 
ATOM 1830 C C   . CYS A 1 281 ? 219.196 230.324 207.136 1.00 91.95  ? 321 CYS A C   1 
ATOM 1831 O O   . CYS A 1 281 ? 220.188 229.654 206.839 1.00 94.52  ? 321 CYS A O   1 
ATOM 1832 C CB  . CYS A 1 281 ? 218.837 230.289 209.603 1.00 92.95  ? 321 CYS A CB  1 
ATOM 1833 S SG  . CYS A 1 281 ? 219.628 231.907 209.617 1.00 112.25 ? 321 CYS A SG  1 
ATOM 1834 N N   . VAL A 1 282 ? 218.869 231.464 206.529 1.00 90.86  ? 322 VAL A N   1 
ATOM 1835 C CA  . VAL A 1 282 ? 219.719 232.105 205.537 1.00 85.54  ? 322 VAL A CA  1 
ATOM 1836 C C   . VAL A 1 282 ? 219.827 233.582 205.887 1.00 88.00  ? 322 VAL A C   1 
ATOM 1837 O O   . VAL A 1 282 ? 219.013 234.128 206.633 1.00 91.61  ? 322 VAL A O   1 
ATOM 1838 C CB  . VAL A 1 282 ? 219.192 231.925 204.099 1.00 84.86  ? 322 VAL A CB  1 
ATOM 1839 C CG1 . VAL A 1 282 ? 219.296 230.473 203.675 1.00 82.76  ? 322 VAL A CG1 1 
ATOM 1840 C CG2 . VAL A 1 282 ? 217.762 232.407 203.997 1.00 86.85  ? 322 VAL A CG2 1 
ATOM 1841 N N   . GLN A 1 283 ? 220.855 234.229 205.345 1.00 87.51  ? 323 GLN A N   1 
ATOM 1842 C CA  . GLN A 1 283 ? 221.119 235.630 205.641 1.00 90.38  ? 323 GLN A CA  1 
ATOM 1843 C C   . GLN A 1 283 ? 221.332 236.405 204.351 1.00 93.93  ? 323 GLN A C   1 
ATOM 1844 O O   . GLN A 1 283 ? 222.106 235.982 203.487 1.00 95.31  ? 323 GLN A O   1 
ATOM 1845 C CB  . GLN A 1 283 ? 222.340 235.783 206.551 1.00 91.15  ? 323 GLN A CB  1 
ATOM 1846 C CG  . GLN A 1 283 ? 222.235 236.943 207.520 1.00 93.30  ? 323 GLN A CG  1 
ATOM 1847 C CD  . GLN A 1 283 ? 223.586 237.483 207.928 1.00 98.30  ? 323 GLN A CD  1 
ATOM 1848 O OE1 . GLN A 1 283 ? 224.623 236.987 207.490 1.00 100.45 ? 323 GLN A OE1 1 
ATOM 1849 N NE2 . GLN A 1 283 ? 223.584 238.506 208.774 1.00 99.70  ? 323 GLN A NE2 1 
ATOM 1850 N N   . ILE A 1 284 ? 220.644 237.537 204.228 1.00 96.01  ? 324 ILE A N   1 
ATOM 1851 C CA  . ILE A 1 284 ? 220.812 238.463 203.115 1.00 95.30  ? 324 ILE A CA  1 
ATOM 1852 C C   . ILE A 1 284 ? 221.029 239.845 203.713 1.00 101.52 ? 324 ILE A C   1 
ATOM 1853 O O   . ILE A 1 284 ? 220.103 240.425 204.295 1.00 104.44 ? 324 ILE A O   1 
ATOM 1854 C CB  . ILE A 1 284 ? 219.606 238.465 202.167 1.00 89.58  ? 324 ILE A CB  1 
ATOM 1855 C CG1 . ILE A 1 284 ? 219.434 237.094 201.516 1.00 86.96  ? 324 ILE A CG1 1 
ATOM 1856 C CG2 . ILE A 1 284 ? 219.769 239.536 201.105 1.00 88.82  ? 324 ILE A CG2 1 
ATOM 1857 C CD1 . ILE A 1 284 ? 218.053 236.860 200.957 1.00 86.96  ? 324 ILE A CD1 1 
ATOM 1858 N N   . LYS A 1 285 ? 222.245 240.373 203.571 1.00 100.22 ? 325 LYS A N   1 
ATOM 1859 C CA  . LYS A 1 285 ? 222.636 241.680 204.117 1.00 99.28  ? 325 LYS A CA  1 
ATOM 1860 C C   . LYS A 1 285 ? 222.303 241.674 205.609 1.00 105.77 ? 325 LYS A C   1 
ATOM 1861 O O   . LYS A 1 285 ? 222.706 240.740 206.315 1.00 106.79 ? 325 LYS A O   1 
ATOM 1862 C CB  . LYS A 1 285 ? 221.982 242.785 203.300 1.00 93.51  ? 325 LYS A CB  1 
ATOM 1863 N N   . ASN A 1 286 ? 221.592 242.670 206.126 1.00 107.01 ? 326 ASN A N   1 
ATOM 1864 C CA  . ASN A 1 286 ? 221.151 242.667 207.520 1.00 103.85 ? 326 ASN A CA  1 
ATOM 1865 C C   . ASN A 1 286 ? 219.719 242.145 207.626 1.00 102.60 ? 326 ASN A C   1 
ATOM 1866 O O   . ASN A 1 286 ? 218.823 242.799 208.157 1.00 102.66 ? 326 ASN A O   1 
ATOM 1867 C CB  . ASN A 1 286 ? 221.278 244.066 208.117 1.00 97.64  ? 326 ASN A CB  1 
ATOM 1868 N N   . ASP A 1 287 ? 219.513 240.937 207.106 1.00 100.57 ? 327 ASP A N   1 
ATOM 1869 C CA  . ASP A 1 287 ? 218.215 240.283 207.173 1.00 98.28  ? 327 ASP A CA  1 
ATOM 1870 C C   . ASP A 1 287 ? 218.429 238.788 207.341 1.00 98.30  ? 327 ASP A C   1 
ATOM 1871 O O   . ASP A 1 287 ? 219.309 238.208 206.701 1.00 97.03  ? 327 ASP A O   1 
ATOM 1872 C CB  . ASP A 1 287 ? 217.379 240.561 205.920 1.00 99.14  ? 327 ASP A CB  1 
ATOM 1873 C CG  . ASP A 1 287 ? 216.753 241.938 205.933 1.00 106.19 ? 327 ASP A CG  1 
ATOM 1874 O OD1 . ASP A 1 287 ? 217.470 242.921 205.652 1.00 108.49 ? 327 ASP A OD1 1 
ATOM 1875 O OD2 . ASP A 1 287 ? 215.543 242.039 206.223 1.00 107.88 ? 327 ASP A OD2 1 
ATOM 1876 N N   . VAL A 1 288 ? 217.621 238.169 208.196 1.00 99.33  ? 328 VAL A N   1 
ATOM 1877 C CA  . VAL A 1 288 ? 217.744 236.751 208.509 1.00 91.85  ? 328 VAL A CA  1 
ATOM 1878 C C   . VAL A 1 288 ? 216.402 236.087 208.249 1.00 89.90  ? 328 VAL A C   1 
ATOM 1879 O O   . VAL A 1 288 ? 215.384 236.502 208.811 1.00 90.21  ? 328 VAL A O   1 
ATOM 1880 C CB  . VAL A 1 288 ? 218.184 236.525 209.963 1.00 86.96  ? 328 VAL A CB  1 
ATOM 1881 C CG1 . VAL A 1 288 ? 218.160 235.050 210.297 1.00 89.05  ? 328 VAL A CG1 1 
ATOM 1882 C CG2 . VAL A 1 288 ? 219.562 237.109 210.184 1.00 89.52  ? 328 VAL A CG2 1 
ATOM 1883 N N   . PHE A 1 289 ? 216.400 235.053 207.416 1.00 89.16  ? 329 PHE A N   1 
ATOM 1884 C CA  . PHE A 1 289 ? 215.190 234.318 207.072 1.00 88.89  ? 329 PHE A CA  1 
ATOM 1885 C C   . PHE A 1 289 ? 215.247 232.943 207.720 1.00 90.92  ? 329 PHE A C   1 
ATOM 1886 O O   . PHE A 1 289 ? 216.211 232.197 207.515 1.00 94.84  ? 329 PHE A O   1 
ATOM 1887 C CB  . PHE A 1 289 ? 215.038 234.186 205.558 1.00 89.11  ? 329 PHE A CB  1 
ATOM 1888 C CG  . PHE A 1 289 ? 214.870 235.496 204.846 1.00 91.24  ? 329 PHE A CG  1 
ATOM 1889 C CD1 . PHE A 1 289 ? 215.972 236.255 204.497 1.00 89.43  ? 329 PHE A CD1 1 
ATOM 1890 C CD2 . PHE A 1 289 ? 213.610 235.962 204.516 1.00 92.70  ? 329 PHE A CD2 1 
ATOM 1891 C CE1 . PHE A 1 289 ? 215.820 237.457 203.839 1.00 90.66  ? 329 PHE A CE1 1 
ATOM 1892 C CE2 . PHE A 1 289 ? 213.453 237.163 203.857 1.00 93.25  ? 329 PHE A CE2 1 
ATOM 1893 C CZ  . PHE A 1 289 ? 214.559 237.911 203.520 1.00 93.82  ? 329 PHE A CZ  1 
ATOM 1894 N N   . ILE A 1 290 ? 214.215 232.614 208.493 1.00 91.21  ? 330 ILE A N   1 
ATOM 1895 C CA  . ILE A 1 290 ? 214.062 231.301 209.106 1.00 87.51  ? 330 ILE A CA  1 
ATOM 1896 C C   . ILE A 1 290 ? 212.910 230.584 208.419 1.00 86.54  ? 330 ILE A C   1 
ATOM 1897 O O   . ILE A 1 290 ? 211.859 231.180 208.155 1.00 88.54  ? 330 ILE A O   1 
ATOM 1898 C CB  . ILE A 1 290 ? 213.832 231.388 210.627 1.00 85.10  ? 330 ILE A CB  1 
ATOM 1899 C CG1 . ILE A 1 290 ? 212.703 232.364 210.951 1.00 87.98  ? 330 ILE A CG1 1 
ATOM 1900 C CG2 . ILE A 1 290 ? 215.110 231.796 211.334 1.00 90.24  ? 330 ILE A CG2 1 
ATOM 1901 C CD1 . ILE A 1 290 ? 212.143 232.199 212.344 1.00 88.00  ? 330 ILE A CD1 1 
ATOM 1902 N N   . CYS A 1 291 ? 213.117 229.305 208.125 1.00 87.21  ? 331 CYS A N   1 
ATOM 1903 C CA  . CYS A 1 291 ? 212.212 228.549 207.272 1.00 86.80  ? 331 CYS A CA  1 
ATOM 1904 C C   . CYS A 1 291 ? 212.179 227.100 207.731 1.00 88.95  ? 331 CYS A C   1 
ATOM 1905 O O   . CYS A 1 291 ? 213.231 226.467 207.863 1.00 96.56  ? 331 CYS A O   1 
ATOM 1906 C CB  . CYS A 1 291 ? 212.663 228.641 205.811 1.00 89.07  ? 331 CYS A CB  1 
ATOM 1907 S SG  . CYS A 1 291 ? 211.620 227.791 204.622 1.00 100.75 ? 331 CYS A SG  1 
ATOM 1908 N N   . GLY A 1 292 ? 210.977 226.584 207.972 1.00 81.80  ? 332 GLY A N   1 
ATOM 1909 C CA  . GLY A 1 292 ? 210.809 225.190 208.322 1.00 83.89  ? 332 GLY A CA  1 
ATOM 1910 C C   . GLY A 1 292 ? 211.076 224.893 209.785 1.00 85.49  ? 332 GLY A C   1 
ATOM 1911 O O   . GLY A 1 292 ? 211.176 225.779 210.636 1.00 87.78  ? 332 GLY A O   1 
ATOM 1912 N N   . GLY A 1 293 ? 211.186 223.599 210.070 1.00 84.23  ? 333 GLY A N   1 
ATOM 1913 C CA  . GLY A 1 293 ? 211.447 223.114 211.412 1.00 84.42  ? 333 GLY A CA  1 
ATOM 1914 C C   . GLY A 1 293 ? 210.193 222.600 212.091 1.00 85.56  ? 333 GLY A C   1 
ATOM 1915 O O   . GLY A 1 293 ? 209.077 222.668 211.567 1.00 84.95  ? 333 GLY A O   1 
ATOM 1916 N N   . TYR A 1 294 ? 210.397 222.069 213.295 1.00 90.41  ? 334 TYR A N   1 
ATOM 1917 C CA  . TYR A 1 294 ? 209.300 221.556 214.100 1.00 90.02  ? 334 TYR A CA  1 
ATOM 1918 C C   . TYR A 1 294 ? 209.654 221.697 215.572 1.00 90.53  ? 334 TYR A C   1 
ATOM 1919 O O   . TYR A 1 294 ? 210.827 221.778 215.944 1.00 92.63  ? 334 TYR A O   1 
ATOM 1920 C CB  . TYR A 1 294 ? 208.980 220.097 213.752 1.00 89.96  ? 334 TYR A CB  1 
ATOM 1921 C CG  . TYR A 1 294 ? 209.897 219.073 214.385 1.00 89.37  ? 334 TYR A CG  1 
ATOM 1922 C CD1 . TYR A 1 294 ? 211.275 219.172 214.267 1.00 89.73  ? 334 TYR A CD1 1 
ATOM 1923 C CD2 . TYR A 1 294 ? 209.378 217.996 215.086 1.00 91.52  ? 334 TYR A CD2 1 
ATOM 1924 C CE1 . TYR A 1 294 ? 212.108 218.233 214.841 1.00 94.26  ? 334 TYR A CE1 1 
ATOM 1925 C CE2 . TYR A 1 294 ? 210.201 217.053 215.660 1.00 94.34  ? 334 TYR A CE2 1 
ATOM 1926 C CZ  . TYR A 1 294 ? 211.565 217.176 215.536 1.00 96.87  ? 334 TYR A CZ  1 
ATOM 1927 O OH  . TYR A 1 294 ? 212.388 216.235 216.110 1.00 101.38 ? 334 TYR A OH  1 
ATOM 1928 N N   . ASN A 1 295 ? 208.620 221.734 216.408 1.00 91.36  ? 335 ASN A N   1 
ATOM 1929 C CA  . ASN A 1 295 ? 208.791 221.876 217.847 1.00 96.91  ? 335 ASN A CA  1 
ATOM 1930 C C   . ASN A 1 295 ? 208.785 220.544 218.584 1.00 99.77  ? 335 ASN A C   1 
ATOM 1931 O O   . ASN A 1 295 ? 208.951 220.530 219.807 1.00 102.28 ? 335 ASN A O   1 
ATOM 1932 C CB  . ASN A 1 295 ? 207.698 222.780 218.422 1.00 96.89  ? 335 ASN A CB  1 
ATOM 1933 C CG  . ASN A 1 295 ? 206.324 222.445 217.883 1.00 97.91  ? 335 ASN A CG  1 
ATOM 1934 O OD1 . ASN A 1 295 ? 206.109 221.369 217.325 1.00 95.53  ? 335 ASN A OD1 1 
ATOM 1935 N ND2 . ASN A 1 295 ? 205.384 223.366 218.048 1.00 97.41  ? 335 ASN A ND2 1 
ATOM 1936 N N   . GLY A 1 296 ? 208.599 219.434 217.878 1.00 96.64  ? 336 GLY A N   1 
ATOM 1937 C CA  . GLY A 1 296 ? 208.550 218.138 218.522 1.00 96.69  ? 336 GLY A CA  1 
ATOM 1938 C C   . GLY A 1 296 ? 207.313 217.345 218.157 1.00 97.24  ? 336 GLY A C   1 
ATOM 1939 O O   . GLY A 1 296 ? 207.368 216.117 218.041 1.00 99.11  ? 336 GLY A O   1 
ATOM 1940 N N   . GLU A 1 297 ? 206.189 218.036 217.968 1.00 96.33  ? 337 GLU A N   1 
ATOM 1941 C CA  . GLU A 1 297 ? 204.930 217.378 217.657 1.00 95.51  ? 337 GLU A CA  1 
ATOM 1942 C C   . GLU A 1 297 ? 204.215 217.941 216.438 1.00 98.76  ? 337 GLU A C   1 
ATOM 1943 O O   . GLU A 1 297 ? 203.278 217.298 215.952 1.00 102.14 ? 337 GLU A O   1 
ATOM 1944 C CB  . GLU A 1 297 ? 203.978 217.447 218.860 1.00 91.18  ? 337 GLU A CB  1 
ATOM 1945 N N   . VAL A 1 298 ? 204.610 219.107 215.933 1.00 98.09  ? 338 VAL A N   1 
ATOM 1946 C CA  . VAL A 1 298 ? 203.968 219.717 214.774 1.00 98.21  ? 338 VAL A CA  1 
ATOM 1947 C C   . VAL A 1 298 ? 205.048 220.250 213.844 1.00 95.83  ? 338 VAL A C   1 
ATOM 1948 O O   . VAL A 1 298 ? 205.957 220.960 214.286 1.00 97.55  ? 338 VAL A O   1 
ATOM 1949 C CB  . VAL A 1 298 ? 203.000 220.845 215.185 1.00 95.36  ? 338 VAL A CB  1 
ATOM 1950 C CG1 . VAL A 1 298 ? 202.688 221.743 214.000 1.00 94.84  ? 338 VAL A CG1 1 
ATOM 1951 C CG2 . VAL A 1 298 ? 201.723 220.261 215.762 1.00 94.13  ? 338 VAL A CG2 1 
ATOM 1952 N N   . ILE A 1 299 ? 204.951 219.911 212.562 1.00 89.14  ? 339 ILE A N   1 
ATOM 1953 C CA  . ILE A 1 299 ? 205.882 220.421 211.562 1.00 84.82  ? 339 ILE A CA  1 
ATOM 1954 C C   . ILE A 1 299 ? 205.392 221.778 211.079 1.00 84.36  ? 339 ILE A C   1 
ATOM 1955 O O   . ILE A 1 299 ? 204.240 221.921 210.655 1.00 87.01  ? 339 ILE A O   1 
ATOM 1956 C CB  . ILE A 1 299 ? 206.023 219.436 210.393 1.00 83.29  ? 339 ILE A CB  1 
ATOM 1957 C CG1 . ILE A 1 299 ? 206.450 218.061 210.902 1.00 88.01  ? 339 ILE A CG1 1 
ATOM 1958 C CG2 . ILE A 1 299 ? 207.024 219.955 209.379 1.00 82.64  ? 339 ILE A CG2 1 
ATOM 1959 C CD1 . ILE A 1 299 ? 206.556 217.024 209.817 1.00 82.12  ? 339 ILE A CD1 1 
ATOM 1960 N N   . LEU A 1 300 ? 206.266 222.776 211.139 1.00 83.46  ? 340 LEU A N   1 
ATOM 1961 C CA  . LEU A 1 300 ? 205.924 224.141 210.765 1.00 85.43  ? 340 LEU A CA  1 
ATOM 1962 C C   . LEU A 1 300 ? 206.369 224.413 209.336 1.00 86.50  ? 340 LEU A C   1 
ATOM 1963 O O   . LEU A 1 300 ? 207.526 224.165 208.982 1.00 87.68  ? 340 LEU A O   1 
ATOM 1964 C CB  . LEU A 1 300 ? 206.572 225.143 211.721 1.00 88.42  ? 340 LEU A CB  1 
ATOM 1965 C CG  . LEU A 1 300 ? 206.156 225.037 213.188 1.00 89.35  ? 340 LEU A CG  1 
ATOM 1966 C CD1 . LEU A 1 300 ? 207.199 225.676 214.085 1.00 88.14  ? 340 LEU A CD1 1 
ATOM 1967 C CD2 . LEU A 1 300 ? 204.796 225.678 213.402 1.00 92.54  ? 340 LEU A CD2 1 
ATOM 1968 N N   . GLY A 1 301 ? 205.452 224.927 208.522 1.00 84.61  ? 341 GLY A N   1 
ATOM 1969 C CA  . GLY A 1 301 ? 205.755 225.231 207.139 1.00 88.02  ? 341 GLY A CA  1 
ATOM 1970 C C   . GLY A 1 301 ? 205.628 226.701 206.803 1.00 93.71  ? 341 GLY A C   1 
ATOM 1971 O O   . GLY A 1 301 ? 205.133 227.058 205.730 1.00 100.07 ? 341 GLY A O   1 
ATOM 1972 N N   . ASP A 1 302 ? 206.064 227.565 207.712 1.00 91.62  ? 342 ASP A N   1 
ATOM 1973 C CA  . ASP A 1 302 ? 206.034 229.005 207.513 1.00 88.40  ? 342 ASP A CA  1 
ATOM 1974 C C   . ASP A 1 302 ? 207.451 229.539 207.355 1.00 91.70  ? 342 ASP A C   1 
ATOM 1975 O O   . ASP A 1 302 ? 208.438 228.821 207.533 1.00 96.99  ? 342 ASP A O   1 
ATOM 1976 C CB  . ASP A 1 302 ? 205.325 229.701 208.679 1.00 88.53  ? 342 ASP A CB  1 
ATOM 1977 C CG  . ASP A 1 302 ? 205.819 229.226 210.028 1.00 90.68  ? 342 ASP A CG  1 
ATOM 1978 O OD1 . ASP A 1 302 ? 206.959 229.569 210.401 1.00 90.23  ? 342 ASP A OD1 1 
ATOM 1979 O OD2 . ASP A 1 302 ? 205.066 228.509 210.718 1.00 91.58  ? 342 ASP A OD2 1 
ATOM 1980 N N   . ILE A 1 303 ? 207.542 230.818 207.009 1.00 88.14  ? 343 ILE A N   1 
ATOM 1981 C CA  . ILE A 1 303 ? 208.822 231.484 206.801 1.00 87.85  ? 343 ILE A CA  1 
ATOM 1982 C C   . ILE A 1 303 ? 208.752 232.872 207.420 1.00 91.21  ? 343 ILE A C   1 
ATOM 1983 O O   . ILE A 1 303 ? 207.764 233.592 207.244 1.00 96.25  ? 343 ILE A O   1 
ATOM 1984 C CB  . ILE A 1 303 ? 209.179 231.553 205.302 1.00 87.85  ? 343 ILE A CB  1 
ATOM 1985 C CG1 . ILE A 1 303 ? 210.325 232.533 205.062 1.00 89.49  ? 343 ILE A CG1 1 
ATOM 1986 C CG2 . ILE A 1 303 ? 207.961 231.936 204.481 1.00 91.77  ? 343 ILE A CG2 1 
ATOM 1987 C CD1 . ILE A 1 303 ? 210.776 232.581 203.629 1.00 91.59  ? 343 ILE A CD1 1 
ATOM 1988 N N   . TRP A 1 304 ? 209.800 233.246 208.152 1.00 89.63  ? 344 TRP A N   1 
ATOM 1989 C CA  . TRP A 1 304 ? 209.839 234.519 208.855 1.00 88.99  ? 344 TRP A CA  1 
ATOM 1990 C C   . TRP A 1 304 ? 211.139 235.245 208.551 1.00 91.00  ? 344 TRP A C   1 
ATOM 1991 O O   . TRP A 1 304 ? 212.150 234.627 208.210 1.00 96.51  ? 344 TRP A O   1 
ATOM 1992 C CB  . TRP A 1 304 ? 209.698 234.329 210.368 1.00 86.84  ? 344 TRP A CB  1 
ATOM 1993 C CG  . TRP A 1 304 ? 208.326 233.928 210.794 1.00 88.37  ? 344 TRP A CG  1 
ATOM 1994 C CD1 . TRP A 1 304 ? 207.742 232.710 210.629 1.00 87.85  ? 344 TRP A CD1 1 
ATOM 1995 C CD2 . TRP A 1 304 ? 207.360 234.750 211.457 1.00 89.84  ? 344 TRP A CD2 1 
ATOM 1996 N NE1 . TRP A 1 304 ? 206.472 232.719 211.149 1.00 90.10  ? 344 TRP A NE1 1 
ATOM 1997 C CE2 . TRP A 1 304 ? 206.213 233.961 211.663 1.00 90.80  ? 344 TRP A CE2 1 
ATOM 1998 C CE3 . TRP A 1 304 ? 207.353 236.076 211.896 1.00 90.26  ? 344 TRP A CE3 1 
ATOM 1999 C CZ2 . TRP A 1 304 ? 205.073 234.453 212.290 1.00 94.68  ? 344 TRP A CZ2 1 
ATOM 2000 C CZ3 . TRP A 1 304 ? 206.221 236.562 212.518 1.00 90.94  ? 344 TRP A CZ3 1 
ATOM 2001 C CH2 . TRP A 1 304 ? 205.096 235.753 212.708 1.00 94.94  ? 344 TRP A CH2 1 
ATOM 2002 N N   . LYS A 1 305 ? 211.101 236.569 208.682 1.00 88.15  ? 345 LYS A N   1 
ATOM 2003 C CA  . LYS A 1 305 ? 212.244 237.428 208.416 1.00 85.85  ? 345 LYS A CA  1 
ATOM 2004 C C   . LYS A 1 305 ? 212.468 238.356 209.600 1.00 87.05  ? 345 LYS A C   1 
ATOM 2005 O O   . LYS A 1 305 ? 211.513 238.880 210.181 1.00 89.59  ? 345 LYS A O   1 
ATOM 2006 C CB  . LYS A 1 305 ? 212.032 238.249 207.139 1.00 86.05  ? 345 LYS A CB  1 
ATOM 2007 C CG  . LYS A 1 305 ? 213.194 239.157 206.780 1.00 91.00  ? 345 LYS A CG  1 
ATOM 2008 C CD  . LYS A 1 305 ? 212.708 240.485 206.224 1.00 92.63  ? 345 LYS A CD  1 
ATOM 2009 C CE  . LYS A 1 305 ? 211.689 240.283 205.117 1.00 92.24  ? 345 LYS A CE  1 
ATOM 2010 N NZ  . LYS A 1 305 ? 211.322 241.568 204.465 1.00 89.30  ? 345 LYS A NZ  1 
ATOM 2011 N N   . LEU A 1 306 ? 213.733 238.548 209.958 1.00 85.92  ? 346 LEU A N   1 
ATOM 2012 C CA  . LEU A 1 306 ? 214.117 239.415 211.062 1.00 86.13  ? 346 LEU A CA  1 
ATOM 2013 C C   . LEU A 1 306 ? 215.187 240.381 210.584 1.00 89.69  ? 346 LEU A C   1 
ATOM 2014 O O   . LEU A 1 306 ? 216.171 239.965 209.965 1.00 93.14  ? 346 LEU A O   1 
ATOM 2015 C CB  . LEU A 1 306 ? 214.632 238.602 212.252 1.00 88.09  ? 346 LEU A CB  1 
ATOM 2016 C CG  . LEU A 1 306 ? 215.302 239.403 213.367 1.00 92.59  ? 346 LEU A CG  1 
ATOM 2017 C CD1 . LEU A 1 306 ? 214.281 239.824 214.407 1.00 91.62  ? 346 LEU A CD1 1 
ATOM 2018 C CD2 . LEU A 1 306 ? 216.420 238.600 214.005 1.00 90.11  ? 346 LEU A CD2 1 
ATOM 2019 N N   . ASN A 1 307 ? 214.992 241.664 210.869 1.00 88.92  ? 347 ASN A N   1 
ATOM 2020 C CA  . ASN A 1 307 ? 215.965 242.692 210.530 1.00 93.02  ? 347 ASN A CA  1 
ATOM 2021 C C   . ASN A 1 307 ? 216.939 242.845 211.692 1.00 95.37  ? 347 ASN A C   1 
ATOM 2022 O O   . ASN A 1 307 ? 216.524 243.112 212.823 1.00 96.99  ? 347 ASN A O   1 
ATOM 2023 C CB  . ASN A 1 307 ? 215.264 244.013 210.223 1.00 97.05  ? 347 ASN A CB  1 
ATOM 2024 C CG  . ASN A 1 307 ? 216.235 245.147 209.980 1.00 103.66 ? 347 ASN A CG  1 
ATOM 2025 O OD1 . ASN A 1 307 ? 216.756 245.745 210.920 1.00 102.53 ? 347 ASN A OD1 1 
ATOM 2026 N ND2 . ASN A 1 307 ? 216.483 245.452 208.713 1.00 107.03 ? 347 ASN A ND2 1 
ATOM 2027 N N   . LEU A 1 308 ? 218.232 242.686 211.411 1.00 96.90  ? 348 LEU A N   1 
ATOM 2028 C CA  . LEU A 1 308 ? 219.235 242.672 212.468 1.00 97.52  ? 348 LEU A CA  1 
ATOM 2029 C C   . LEU A 1 308 ? 219.455 244.036 213.107 1.00 103.76 ? 348 LEU A C   1 
ATOM 2030 O O   . LEU A 1 308 ? 220.154 244.114 214.122 1.00 109.37 ? 348 LEU A O   1 
ATOM 2031 C CB  . LEU A 1 308 ? 220.560 242.142 211.921 1.00 98.05  ? 348 LEU A CB  1 
ATOM 2032 C CG  . LEU A 1 308 ? 220.590 240.647 211.605 1.00 98.38  ? 348 LEU A CG  1 
ATOM 2033 C CD1 . LEU A 1 308 ? 222.016 240.172 211.411 1.00 98.99  ? 348 LEU A CD1 1 
ATOM 2034 C CD2 . LEU A 1 308 ? 219.907 239.861 212.708 1.00 94.82  ? 348 LEU A CD2 1 
ATOM 2035 N N   . GLN A 1 309 ? 218.892 245.106 212.548 1.00 105.22 ? 349 GLN A N   1 
ATOM 2036 C CA  . GLN A 1 309 ? 219.051 246.441 213.111 1.00 105.98 ? 349 GLN A CA  1 
ATOM 2037 C C   . GLN A 1 309 ? 217.880 246.846 213.999 1.00 102.80 ? 349 GLN A C   1 
ATOM 2038 O O   . GLN A 1 309 ? 218.089 247.318 215.119 1.00 101.81 ? 349 GLN A O   1 
ATOM 2039 C CB  . GLN A 1 309 ? 219.236 247.468 211.988 1.00 102.29 ? 349 GLN A CB  1 
ATOM 2040 N N   . THR A 1 310 ? 216.648 246.674 213.521 1.00 101.88 ? 350 THR A N   1 
ATOM 2041 C CA  . THR A 1 310 ? 215.469 247.043 214.293 1.00 104.50 ? 350 THR A CA  1 
ATOM 2042 C C   . THR A 1 310 ? 214.841 245.870 215.034 1.00 104.47 ? 350 THR A C   1 
ATOM 2043 O O   . THR A 1 310 ? 213.971 246.095 215.881 1.00 104.77 ? 350 THR A O   1 
ATOM 2044 C CB  . THR A 1 310 ? 214.413 247.687 213.387 1.00 104.41 ? 350 THR A CB  1 
ATOM 2045 O OG1 . THR A 1 310 ? 213.258 248.021 214.164 1.00 108.94 ? 350 THR A OG1 1 
ATOM 2046 C CG2 . THR A 1 310 ? 214.005 246.732 212.284 1.00 99.39  ? 350 THR A CG2 1 
ATOM 2047 N N   . PHE A 1 311 ? 215.259 244.637 214.742 1.00 101.08 ? 351 PHE A N   1 
ATOM 2048 C CA  . PHE A 1 311 ? 214.760 243.440 215.424 1.00 95.50  ? 351 PHE A CA  1 
ATOM 2049 C C   . PHE A 1 311 ? 213.238 243.335 215.335 1.00 93.23  ? 351 PHE A C   1 
ATOM 2050 O O   . PHE A 1 311 ? 212.551 243.051 216.318 1.00 93.23  ? 351 PHE A O   1 
ATOM 2051 C CB  . PHE A 1 311 ? 215.231 243.407 216.879 1.00 92.30  ? 351 PHE A CB  1 
ATOM 2052 C CG  . PHE A 1 311 ? 216.720 243.380 217.028 1.00 91.47  ? 351 PHE A CG  1 
ATOM 2053 C CD1 . PHE A 1 311 ? 217.451 242.288 216.599 1.00 92.47  ? 351 PHE A CD1 1 
ATOM 2054 C CD2 . PHE A 1 311 ? 217.391 244.448 217.594 1.00 94.85  ? 351 PHE A CD2 1 
ATOM 2055 C CE1 . PHE A 1 311 ? 218.824 242.261 216.731 1.00 97.50  ? 351 PHE A CE1 1 
ATOM 2056 C CE2 . PHE A 1 311 ? 218.765 244.427 217.730 1.00 95.66  ? 351 PHE A CE2 1 
ATOM 2057 C CZ  . PHE A 1 311 ? 219.482 243.332 217.298 1.00 95.82  ? 351 PHE A CZ  1 
ATOM 2058 N N   . GLN A 1 312 ? 212.711 243.566 214.139 1.00 88.65  ? 352 GLN A N   1 
ATOM 2059 C CA  . GLN A 1 312 ? 211.282 243.479 213.878 1.00 87.03  ? 352 GLN A CA  1 
ATOM 2060 C C   . GLN A 1 312 ? 210.996 242.230 213.056 1.00 93.10  ? 352 GLN A C   1 
ATOM 2061 O O   . GLN A 1 312 ? 211.657 241.987 212.041 1.00 96.90  ? 352 GLN A O   1 
ATOM 2062 C CB  . GLN A 1 312 ? 210.785 244.727 213.146 1.00 90.71  ? 352 GLN A CB  1 
ATOM 2063 C CG  . GLN A 1 312 ? 209.491 244.529 212.382 1.00 98.11  ? 352 GLN A CG  1 
ATOM 2064 C CD  . GLN A 1 312 ? 208.297 244.356 213.295 1.00 100.69 ? 352 GLN A CD  1 
ATOM 2065 O OE1 . GLN A 1 312 ? 208.091 245.138 214.221 1.00 102.14 ? 352 GLN A OE1 1 
ATOM 2066 N NE2 . GLN A 1 312 ? 207.499 243.328 213.036 1.00 98.12  ? 352 GLN A NE2 1 
ATOM 2067 N N   . TRP A 1 313 ? 210.019 241.443 213.497 1.00 94.03  ? 353 TRP A N   1 
ATOM 2068 C CA  . TRP A 1 313 ? 209.644 240.211 212.817 1.00 93.50  ? 353 TRP A CA  1 
ATOM 2069 C C   . TRP A 1 313 ? 208.634 240.498 211.715 1.00 91.32  ? 353 TRP A C   1 
ATOM 2070 O O   . TRP A 1 313 ? 207.716 241.303 211.891 1.00 91.46  ? 353 TRP A O   1 
ATOM 2071 C CB  . TRP A 1 313 ? 209.050 239.206 213.804 1.00 91.68  ? 353 TRP A CB  1 
ATOM 2072 C CG  . TRP A 1 313 ? 210.059 238.455 214.614 1.00 88.78  ? 353 TRP A CG  1 
ATOM 2073 C CD1 . TRP A 1 313 ? 210.274 238.563 215.955 1.00 91.33  ? 353 TRP A CD1 1 
ATOM 2074 C CD2 . TRP A 1 313 ? 210.977 237.464 214.140 1.00 85.47  ? 353 TRP A CD2 1 
ATOM 2075 N NE1 . TRP A 1 313 ? 211.274 237.708 216.345 1.00 87.73  ? 353 TRP A NE1 1 
ATOM 2076 C CE2 . TRP A 1 313 ? 211.722 237.021 215.248 1.00 85.41  ? 353 TRP A CE2 1 
ATOM 2077 C CE3 . TRP A 1 313 ? 211.244 236.911 212.886 1.00 89.52  ? 353 TRP A CE3 1 
ATOM 2078 C CZ2 . TRP A 1 313 ? 212.715 236.054 215.140 1.00 90.13  ? 353 TRP A CZ2 1 
ATOM 2079 C CZ3 . TRP A 1 313 ? 212.230 235.951 212.781 1.00 91.31  ? 353 TRP A CZ3 1 
ATOM 2080 C CH2 . TRP A 1 313 ? 212.953 235.532 213.901 1.00 90.03  ? 353 TRP A CH2 1 
ATOM 2081 N N   . VAL A 1 314 ? 208.810 239.834 210.575 1.00 89.73  ? 354 VAL A N   1 
ATOM 2082 C CA  . VAL A 1 314 ? 207.888 239.927 209.450 1.00 90.73  ? 354 VAL A CA  1 
ATOM 2083 C C   . VAL A 1 314 ? 207.551 238.514 208.998 1.00 92.48  ? 354 VAL A C   1 
ATOM 2084 O O   . VAL A 1 314 ? 208.449 237.687 208.813 1.00 93.95  ? 354 VAL A O   1 
ATOM 2085 C CB  . VAL A 1 314 ? 208.483 240.738 208.284 1.00 91.47  ? 354 VAL A CB  1 
ATOM 2086 C CG1 . VAL A 1 314 ? 207.520 240.764 207.111 1.00 92.51  ? 354 VAL A CG1 1 
ATOM 2087 C CG2 . VAL A 1 314 ? 208.817 242.151 208.734 1.00 91.63  ? 354 VAL A CG2 1 
ATOM 2088 N N   . LYS A 1 315 ? 206.263 238.233 208.824 1.00 94.36  ? 355 LYS A N   1 
ATOM 2089 C CA  . LYS A 1 315 ? 205.808 236.927 208.361 1.00 96.62  ? 355 LYS A CA  1 
ATOM 2090 C C   . LYS A 1 315 ? 205.493 237.027 206.874 1.00 99.90  ? 355 LYS A C   1 
ATOM 2091 O O   . LYS A 1 315 ? 204.499 237.648 206.484 1.00 104.50 ? 355 LYS A O   1 
ATOM 2092 C CB  . LYS A 1 315 ? 204.589 236.456 209.147 1.00 97.04  ? 355 LYS A CB  1 
ATOM 2093 C CG  . LYS A 1 315 ? 204.167 235.034 208.817 1.00 90.99  ? 355 LYS A CG  1 
ATOM 2094 C CD  . LYS A 1 315 ? 202.864 234.666 209.500 1.00 94.87  ? 355 LYS A CD  1 
ATOM 2095 C CE  . LYS A 1 315 ? 202.209 233.477 208.820 1.00 100.75 ? 355 LYS A CE  1 
ATOM 2096 N NZ  . LYS A 1 315 ? 201.433 233.885 207.618 1.00 105.70 ? 355 LYS A NZ  1 
ATOM 2097 N N   . LEU A 1 316 ? 206.336 236.417 206.050 1.00 97.55  ? 356 LEU A N   1 
ATOM 2098 C CA  . LEU A 1 316 ? 206.106 236.438 204.615 1.00 96.62  ? 356 LEU A CA  1 
ATOM 2099 C C   . LEU A 1 316 ? 204.851 235.638 204.279 1.00 99.63  ? 356 LEU A C   1 
ATOM 2100 O O   . LEU A 1 316 ? 204.611 234.580 204.870 1.00 101.80 ? 356 LEU A O   1 
ATOM 2101 C CB  . LEU A 1 316 ? 207.311 235.870 203.868 1.00 92.32  ? 356 LEU A CB  1 
ATOM 2102 C CG  . LEU A 1 316 ? 208.662 236.500 204.207 1.00 93.96  ? 356 LEU A CG  1 
ATOM 2103 C CD1 . LEU A 1 316 ? 209.730 236.034 203.237 1.00 92.65  ? 356 LEU A CD1 1 
ATOM 2104 C CD2 . LEU A 1 316 ? 208.563 238.015 204.200 1.00 98.72  ? 356 LEU A CD2 1 
ATOM 2105 N N   . PRO A 1 317 ? 204.031 236.110 203.337 1.00 98.03  ? 357 PRO A N   1 
ATOM 2106 C CA  . PRO A 1 317 ? 202.761 235.450 203.009 1.00 103.10 ? 357 PRO A CA  1 
ATOM 2107 C C   . PRO A 1 317 ? 202.922 234.244 202.086 1.00 107.22 ? 357 PRO A C   1 
ATOM 2108 O O   . PRO A 1 317 ? 202.198 234.091 201.101 1.00 110.37 ? 357 PRO A O   1 
ATOM 2109 C CB  . PRO A 1 317 ? 201.964 236.573 202.339 1.00 100.47 ? 357 PRO A CB  1 
ATOM 2110 C CG  . PRO A 1 317 ? 203.006 237.398 201.669 1.00 97.35  ? 357 PRO A CG  1 
ATOM 2111 C CD  . PRO A 1 317 ? 204.250 237.317 202.521 1.00 95.24  ? 357 PRO A CD  1 
ATOM 2112 N N   . ALA A 1 318 ? 203.878 233.379 202.410 1.00 104.71 ? 358 ALA A N   1 
ATOM 2113 C CA  . ALA A 1 318 ? 204.153 232.184 201.627 1.00 102.48 ? 358 ALA A CA  1 
ATOM 2114 C C   . ALA A 1 318 ? 204.145 230.974 202.544 1.00 106.46 ? 358 ALA A C   1 
ATOM 2115 O O   . ALA A 1 318 ? 204.783 230.989 203.601 1.00 109.46 ? 358 ALA A O   1 
ATOM 2116 C CB  . ALA A 1 318 ? 205.497 232.293 200.902 1.00 100.44 ? 358 ALA A CB  1 
ATOM 2117 N N   . THR A 1 319 ? 203.425 229.934 202.140 1.00 107.66 ? 359 THR A N   1 
ATOM 2118 C CA  . THR A 1 319 ? 203.378 228.673 202.865 1.00 108.98 ? 359 THR A CA  1 
ATOM 2119 C C   . THR A 1 319 ? 203.861 227.560 201.948 1.00 108.24 ? 359 THR A C   1 
ATOM 2120 O O   . THR A 1 319 ? 203.532 227.537 200.758 1.00 111.04 ? 359 THR A O   1 
ATOM 2121 C CB  . THR A 1 319 ? 201.965 228.369 203.369 1.00 111.96 ? 359 THR A CB  1 
ATOM 2122 O OG1 . THR A 1 319 ? 201.394 229.555 203.934 1.00 114.30 ? 359 THR A OG1 1 
ATOM 2123 C CG2 . THR A 1 319 ? 202.002 227.282 204.430 1.00 105.43 ? 359 THR A CG2 1 
ATOM 2124 N N   . MET A 1 320 ? 204.646 226.645 202.504 1.00 102.62 ? 360 MET A N   1 
ATOM 2125 C CA  . MET A 1 320 ? 205.254 225.603 201.695 1.00 101.94 ? 360 MET A CA  1 
ATOM 2126 C C   . MET A 1 320 ? 204.180 224.692 201.107 1.00 104.20 ? 360 MET A C   1 
ATOM 2127 O O   . MET A 1 320 ? 203.161 224.432 201.758 1.00 103.32 ? 360 MET A O   1 
ATOM 2128 C CB  . MET A 1 320 ? 206.218 224.767 202.531 1.00 101.85 ? 360 MET A CB  1 
ATOM 2129 C CG  . MET A 1 320 ? 207.023 225.557 203.527 1.00 103.92 ? 360 MET A CG  1 
ATOM 2130 S SD  . MET A 1 320 ? 208.688 224.908 203.697 1.00 116.13 ? 360 MET A SD  1 
ATOM 2131 C CE  . MET A 1 320 ? 209.096 225.589 205.291 1.00 91.64  ? 360 MET A CE  1 
ATOM 2132 N N   . PRO A 1 321 ? 204.367 224.201 199.882 1.00 105.46 ? 361 PRO A N   1 
ATOM 2133 C CA  . PRO A 1 321 ? 203.487 223.132 199.389 1.00 107.44 ? 361 PRO A CA  1 
ATOM 2134 C C   . PRO A 1 321 ? 203.562 221.878 200.238 1.00 103.98 ? 361 PRO A C   1 
ATOM 2135 O O   . PRO A 1 321 ? 202.552 221.181 200.397 1.00 103.30 ? 361 PRO A O   1 
ATOM 2136 C CB  . PRO A 1 321 ? 203.997 222.886 197.962 1.00 106.82 ? 361 PRO A CB  1 
ATOM 2137 C CG  . PRO A 1 321 ? 204.793 224.109 197.611 1.00 104.98 ? 361 PRO A CG  1 
ATOM 2138 C CD  . PRO A 1 321 ? 205.385 224.586 198.894 1.00 102.66 ? 361 PRO A CD  1 
ATOM 2139 N N   . GLU A 1 322 ? 204.734 221.573 200.789 1.00 100.09 ? 362 GLU A N   1 
ATOM 2140 C CA  . GLU A 1 322 ? 204.927 220.435 201.676 1.00 99.08  ? 362 GLU A CA  1 
ATOM 2141 C C   . GLU A 1 322 ? 205.778 220.863 202.865 1.00 96.47  ? 362 GLU A C   1 
ATOM 2142 O O   . GLU A 1 322 ? 206.991 221.059 202.720 1.00 96.70  ? 362 GLU A O   1 
ATOM 2143 C CB  . GLU A 1 322 ? 205.584 219.272 200.933 1.00 95.96  ? 362 GLU A CB  1 
ATOM 2144 N N   . PRO A 1 323 ? 205.186 221.032 204.045 1.00 90.35  ? 363 PRO A N   1 
ATOM 2145 C CA  . PRO A 1 323 ? 205.968 221.477 205.207 1.00 87.11  ? 363 PRO A CA  1 
ATOM 2146 C C   . PRO A 1 323 ? 206.901 220.376 205.688 1.00 84.93  ? 363 PRO A C   1 
ATOM 2147 O O   . PRO A 1 323 ? 206.471 219.252 205.952 1.00 87.35  ? 363 PRO A O   1 
ATOM 2148 C CB  . PRO A 1 323 ? 204.897 221.806 206.255 1.00 92.13  ? 363 PRO A CB  1 
ATOM 2149 C CG  . PRO A 1 323 ? 203.595 221.849 205.499 1.00 95.40  ? 363 PRO A CG  1 
ATOM 2150 C CD  . PRO A 1 323 ? 203.756 220.904 204.360 1.00 89.05  ? 363 PRO A CD  1 
ATOM 2151 N N   . VAL A 1 324 ? 208.188 220.708 205.802 1.00 82.63  ? 364 VAL A N   1 
ATOM 2152 C CA  . VAL A 1 324 ? 209.216 219.751 206.185 1.00 82.51  ? 364 VAL A CA  1 
ATOM 2153 C C   . VAL A 1 324 ? 210.088 220.337 207.286 1.00 78.69  ? 364 VAL A C   1 
ATOM 2154 O O   . VAL A 1 324 ? 210.101 221.545 207.532 1.00 82.63  ? 364 VAL A O   1 
ATOM 2155 C CB  . VAL A 1 324 ? 210.100 219.322 204.993 1.00 82.22  ? 364 VAL A CB  1 
ATOM 2156 C CG1 . VAL A 1 324 ? 209.263 219.066 203.758 1.00 87.13  ? 364 VAL A CG1 1 
ATOM 2157 C CG2 . VAL A 1 324 ? 211.132 220.388 204.702 1.00 76.92  ? 364 VAL A CG2 1 
ATOM 2158 N N   . TYR A 1 325 ? 210.818 219.449 207.955 1.00 77.79  ? 365 TYR A N   1 
ATOM 2159 C CA  . TYR A 1 325 ? 211.855 219.804 208.910 1.00 79.67  ? 365 TYR A CA  1 
ATOM 2160 C C   . TYR A 1 325 ? 213.078 218.945 208.626 1.00 78.93  ? 365 TYR A C   1 
ATOM 2161 O O   . TYR A 1 325 ? 213.030 218.009 207.825 1.00 82.20  ? 365 TYR A O   1 
ATOM 2162 C CB  . TYR A 1 325 ? 211.388 219.611 210.358 1.00 84.11  ? 365 TYR A CB  1 
ATOM 2163 C CG  . TYR A 1 325 ? 211.208 218.165 210.753 1.00 85.38  ? 365 TYR A CG  1 
ATOM 2164 C CD1 . TYR A 1 325 ? 210.030 217.492 210.468 1.00 84.81  ? 365 TYR A CD1 1 
ATOM 2165 C CD2 . TYR A 1 325 ? 212.214 217.473 211.410 1.00 83.85  ? 365 TYR A CD2 1 
ATOM 2166 C CE1 . TYR A 1 325 ? 209.860 216.174 210.824 1.00 85.44  ? 365 TYR A CE1 1 
ATOM 2167 C CE2 . TYR A 1 325 ? 212.052 216.153 211.769 1.00 83.49  ? 365 TYR A CE2 1 
ATOM 2168 C CZ  . TYR A 1 325 ? 210.874 215.509 211.473 1.00 88.42  ? 365 TYR A CZ  1 
ATOM 2169 O OH  . TYR A 1 325 ? 210.707 214.192 211.830 1.00 97.29  ? 365 TYR A OH  1 
ATOM 2170 N N   . PHE A 1 326 ? 214.186 219.275 209.288 1.00 76.42  ? 366 PHE A N   1 
ATOM 2171 C CA  . PHE A 1 326 ? 215.461 218.587 209.099 1.00 80.61  ? 366 PHE A CA  1 
ATOM 2172 C C   . PHE A 1 326 ? 215.936 218.647 207.652 1.00 84.54  ? 366 PHE A C   1 
ATOM 2173 O O   . PHE A 1 326 ? 216.726 217.803 207.218 1.00 84.01  ? 366 PHE A O   1 
ATOM 2174 C CB  . PHE A 1 326 ? 215.386 217.130 209.566 1.00 85.18  ? 366 PHE A CB  1 
ATOM 2175 C CG  . PHE A 1 326 ? 216.156 216.853 210.823 1.00 89.37  ? 366 PHE A CG  1 
ATOM 2176 C CD1 . PHE A 1 326 ? 217.537 216.858 210.819 1.00 92.96  ? 366 PHE A CD1 1 
ATOM 2177 C CD2 . PHE A 1 326 ? 215.497 216.583 212.008 1.00 85.64  ? 366 PHE A CD2 1 
ATOM 2178 C CE1 . PHE A 1 326 ? 218.246 216.599 211.972 1.00 88.76  ? 366 PHE A CE1 1 
ATOM 2179 C CE2 . PHE A 1 326 ? 216.202 216.326 213.163 1.00 88.15  ? 366 PHE A CE2 1 
ATOM 2180 C CZ  . PHE A 1 326 ? 217.578 216.335 213.145 1.00 87.69  ? 366 PHE A CZ  1 
ATOM 2181 N N   . HIS A 1 327 ? 215.464 219.634 206.899 1.00 82.14  ? 367 HIS A N   1 
ATOM 2182 C CA  . HIS A 1 327 ? 215.806 219.791 205.496 1.00 77.47  ? 367 HIS A CA  1 
ATOM 2183 C C   . HIS A 1 327 ? 217.088 220.606 205.368 1.00 81.13  ? 367 HIS A C   1 
ATOM 2184 O O   . HIS A 1 327 ? 217.796 220.854 206.347 1.00 89.89  ? 367 HIS A O   1 
ATOM 2185 C CB  . HIS A 1 327 ? 214.659 220.456 204.747 1.00 74.80  ? 367 HIS A CB  1 
ATOM 2186 C CG  . HIS A 1 327 ? 214.330 221.827 205.249 1.00 78.32  ? 367 HIS A CG  1 
ATOM 2187 N ND1 . HIS A 1 327 ? 213.802 222.052 206.501 1.00 79.01  ? 367 HIS A ND1 1 
ATOM 2188 C CD2 . HIS A 1 327 ? 214.459 223.043 204.671 1.00 83.48  ? 367 HIS A CD2 1 
ATOM 2189 C CE1 . HIS A 1 327 ? 213.617 223.349 206.672 1.00 78.15  ? 367 HIS A CE1 1 
ATOM 2190 N NE2 . HIS A 1 327 ? 214.006 223.972 205.576 1.00 80.16  ? 367 HIS A NE2 1 
ATOM 2191 N N   . CYS A 1 328 ? 217.400 221.036 204.150 1.00 78.09  ? 368 CYS A N   1 
ATOM 2192 C CA  . CYS A 1 328 ? 218.513 221.941 203.919 1.00 79.54  ? 368 CYS A CA  1 
ATOM 2193 C C   . CYS A 1 328 ? 218.019 223.128 203.108 1.00 83.08  ? 368 CYS A C   1 
ATOM 2194 O O   . CYS A 1 328 ? 217.136 222.987 202.255 1.00 86.39  ? 368 CYS A O   1 
ATOM 2195 C CB  . CYS A 1 328 ? 219.670 221.247 203.195 1.00 79.32  ? 368 CYS A CB  1 
ATOM 2196 S SG  . CYS A 1 328 ? 219.639 221.394 201.400 1.00 93.38  ? 368 CYS A SG  1 
ATOM 2197 N N   . ALA A 1 329 ? 218.581 224.299 203.392 1.00 80.62  ? 369 ALA A N   1 
ATOM 2198 C CA  . ALA A 1 329 ? 218.238 225.515 202.673 1.00 79.70  ? 369 ALA A CA  1 
ATOM 2199 C C   . ALA A 1 329 ? 219.502 226.319 202.420 1.00 83.58  ? 369 ALA A C   1 
ATOM 2200 O O   . ALA A 1 329 ? 220.464 226.255 203.189 1.00 85.26  ? 369 ALA A O   1 
ATOM 2201 C CB  . ALA A 1 329 ? 217.222 226.365 203.442 1.00 79.11  ? 369 ALA A CB  1 
ATOM 2202 N N   . ALA A 1 330 ? 219.486 227.080 201.331 1.00 86.59  ? 370 ALA A N   1 
ATOM 2203 C CA  . ALA A 1 330 ? 220.629 227.897 200.954 1.00 84.66  ? 370 ALA A CA  1 
ATOM 2204 C C   . ALA A 1 330 ? 220.131 229.118 200.201 1.00 82.20  ? 370 ALA A C   1 
ATOM 2205 O O   . ALA A 1 330 ? 218.991 229.161 199.738 1.00 82.21  ? 370 ALA A O   1 
ATOM 2206 C CB  . ALA A 1 330 ? 221.630 227.111 200.102 1.00 84.15  ? 370 ALA A CB  1 
ATOM 2207 N N   . VAL A 1 331 ? 220.996 230.120 200.091 1.00 80.08  ? 371 VAL A N   1 
ATOM 2208 C CA  . VAL A 1 331 ? 220.668 231.346 199.380 1.00 80.01  ? 371 VAL A CA  1 
ATOM 2209 C C   . VAL A 1 331 ? 221.777 231.647 198.384 1.00 83.67  ? 371 VAL A C   1 
ATOM 2210 O O   . VAL A 1 331 ? 222.943 231.301 198.596 1.00 88.71  ? 371 VAL A O   1 
ATOM 2211 C CB  . VAL A 1 331 ? 220.450 232.534 200.346 1.00 84.91  ? 371 VAL A CB  1 
ATOM 2212 C CG1 . VAL A 1 331 ? 221.776 233.077 200.850 1.00 90.08  ? 371 VAL A CG1 1 
ATOM 2213 C CG2 . VAL A 1 331 ? 219.635 233.626 199.676 1.00 85.31  ? 371 VAL A CG2 1 
ATOM 2214 N N   . THR A 1 332 ? 221.402 232.272 197.284 1.00 85.47  ? 372 THR A N   1 
ATOM 2215 C CA  . THR A 1 332 ? 222.322 232.678 196.239 1.00 87.56  ? 372 THR A CA  1 
ATOM 2216 C C   . THR A 1 332 ? 222.674 234.148 196.389 1.00 93.55  ? 372 THR A C   1 
ATOM 2217 O O   . THR A 1 332 ? 221.930 234.916 197.006 1.00 96.23  ? 372 THR A O   1 
ATOM 2218 C CB  . THR A 1 332 ? 221.703 232.433 194.859 1.00 85.13  ? 372 THR A CB  1 
ATOM 2219 O OG1 . THR A 1 332 ? 220.366 232.944 194.837 1.00 87.87  ? 372 THR A OG1 1 
ATOM 2220 C CG2 . THR A 1 332 ? 221.674 230.950 194.549 1.00 85.26  ? 372 THR A CG2 1 
ATOM 2221 N N   . PRO A 1 333 ? 223.816 234.579 195.847 1.00 95.10  ? 373 PRO A N   1 
ATOM 2222 C CA  . PRO A 1 333 ? 224.142 236.013 195.893 1.00 93.36  ? 373 PRO A CA  1 
ATOM 2223 C C   . PRO A 1 333 ? 223.088 236.886 195.239 1.00 95.35  ? 373 PRO A C   1 
ATOM 2224 O O   . PRO A 1 333 ? 222.923 238.045 195.638 1.00 97.72  ? 373 PRO A O   1 
ATOM 2225 C CB  . PRO A 1 333 ? 225.482 236.087 195.151 1.00 92.64  ? 373 PRO A CB  1 
ATOM 2226 C CG  . PRO A 1 333 ? 226.083 234.742 195.340 1.00 95.69  ? 373 PRO A CG  1 
ATOM 2227 C CD  . PRO A 1 333 ? 224.935 233.776 195.326 1.00 93.39  ? 373 PRO A CD  1 
ATOM 2228 N N   . ALA A 1 334 ? 222.370 236.365 194.243 1.00 93.12  ? 374 ALA A N   1 
ATOM 2229 C CA  . ALA A 1 334 ? 221.278 237.123 193.642 1.00 92.54  ? 374 ALA A CA  1 
ATOM 2230 C C   . ALA A 1 334 ? 220.175 237.397 194.656 1.00 94.18  ? 374 ALA A C   1 
ATOM 2231 O O   . ALA A 1 334 ? 219.608 238.495 194.684 1.00 98.36  ? 374 ALA A O   1 
ATOM 2232 C CB  . ALA A 1 334 ? 220.721 236.373 192.433 1.00 90.96  ? 374 ALA A CB  1 
ATOM 2233 N N   . GLY A 1 335 ? 219.856 236.415 195.494 1.00 90.69  ? 375 GLY A N   1 
ATOM 2234 C CA  . GLY A 1 335 ? 218.829 236.589 196.501 1.00 88.64  ? 375 GLY A CA  1 
ATOM 2235 C C   . GLY A 1 335 ? 217.711 235.572 196.407 1.00 90.28  ? 375 GLY A C   1 
ATOM 2236 O O   . GLY A 1 335 ? 216.595 235.822 196.870 1.00 92.38  ? 375 GLY A O   1 
ATOM 2237 N N   . CYS A 1 336 ? 218.000 234.420 195.812 1.00 90.82  ? 376 CYS A N   1 
ATOM 2238 C CA  . CYS A 1 336 ? 217.036 233.340 195.659 1.00 88.01  ? 376 CYS A CA  1 
ATOM 2239 C C   . CYS A 1 336 ? 217.367 232.234 196.649 1.00 88.20  ? 376 CYS A C   1 
ATOM 2240 O O   . CYS A 1 336 ? 218.529 231.832 196.768 1.00 93.17  ? 376 CYS A O   1 
ATOM 2241 C CB  . CYS A 1 336 ? 217.050 232.795 194.230 1.00 87.58  ? 376 CYS A CB  1 
ATOM 2242 S SG  . CYS A 1 336 ? 215.507 232.027 193.699 1.00 92.73  ? 376 CYS A SG  1 
ATOM 2243 N N   . MET A 1 337 ? 216.352 231.747 197.356 1.00 84.92  ? 377 MET A N   1 
ATOM 2244 C CA  . MET A 1 337 ? 216.526 230.704 198.356 1.00 83.81  ? 377 MET A CA  1 
ATOM 2245 C C   . MET A 1 337 ? 216.056 229.369 197.796 1.00 85.29  ? 377 MET A C   1 
ATOM 2246 O O   . MET A 1 337 ? 214.965 229.276 197.220 1.00 87.16  ? 377 MET A O   1 
ATOM 2247 C CB  . MET A 1 337 ? 215.762 231.038 199.637 1.00 88.18  ? 377 MET A CB  1 
ATOM 2248 C CG  . MET A 1 337 ? 215.356 229.817 200.447 1.00 91.92  ? 377 MET A CG  1 
ATOM 2249 S SD  . MET A 1 337 ? 215.306 230.128 202.220 1.00 97.10  ? 377 MET A SD  1 
ATOM 2250 C CE  . MET A 1 337 ? 213.688 230.866 202.378 1.00 95.64  ? 377 MET A CE  1 
ATOM 2251 N N   . TYR A 1 338 ? 216.883 228.344 197.971 1.00 81.60  ? 378 TYR A N   1 
ATOM 2252 C CA  . TYR A 1 338 ? 216.586 226.984 197.552 1.00 80.31  ? 378 TYR A CA  1 
ATOM 2253 C C   . TYR A 1 338 ? 216.441 226.093 198.777 1.00 82.09  ? 378 TYR A C   1 
ATOM 2254 O O   . TYR A 1 338 ? 217.187 226.234 199.752 1.00 86.38  ? 378 TYR A O   1 
ATOM 2255 C CB  . TYR A 1 338 ? 217.685 226.440 196.637 1.00 79.38  ? 378 TYR A CB  1 
ATOM 2256 C CG  . TYR A 1 338 ? 217.712 227.084 195.273 1.00 83.26  ? 378 TYR A CG  1 
ATOM 2257 C CD1 . TYR A 1 338 ? 218.351 228.297 195.071 1.00 83.86  ? 378 TYR A CD1 1 
ATOM 2258 C CD2 . TYR A 1 338 ? 217.095 226.481 194.188 1.00 83.80  ? 378 TYR A CD2 1 
ATOM 2259 C CE1 . TYR A 1 338 ? 218.376 228.890 193.828 1.00 84.22  ? 378 TYR A CE1 1 
ATOM 2260 C CE2 . TYR A 1 338 ? 217.115 227.067 192.941 1.00 84.49  ? 378 TYR A CE2 1 
ATOM 2261 C CZ  . TYR A 1 338 ? 217.757 228.272 192.767 1.00 86.27  ? 378 TYR A CZ  1 
ATOM 2262 O OH  . TYR A 1 338 ? 217.781 228.860 191.525 1.00 88.10  ? 378 TYR A OH  1 
ATOM 2263 N N   . ILE A 1 339 ? 215.474 225.180 198.722 1.00 80.60  ? 379 ILE A N   1 
ATOM 2264 C CA  . ILE A 1 339 ? 215.163 224.269 199.816 1.00 75.83  ? 379 ILE A CA  1 
ATOM 2265 C C   . ILE A 1 339 ? 215.091 222.858 199.254 1.00 73.98  ? 379 ILE A C   1 
ATOM 2266 O O   . ILE A 1 339 ? 214.418 222.624 198.244 1.00 81.77  ? 379 ILE A O   1 
ATOM 2267 C CB  . ILE A 1 339 ? 213.839 224.645 200.505 1.00 73.75  ? 379 ILE A CB  1 
ATOM 2268 C CG1 . ILE A 1 339 ? 214.019 225.906 201.348 1.00 77.18  ? 379 ILE A CG1 1 
ATOM 2269 C CG2 . ILE A 1 339 ? 213.328 223.496 201.354 1.00 70.88  ? 379 ILE A CG2 1 
ATOM 2270 C CD1 . ILE A 1 339 ? 212.924 226.921 201.156 1.00 79.77  ? 379 ILE A CD1 1 
ATOM 2271 N N   . HIS A 1 340 ? 215.778 221.919 199.903 1.00 71.18  ? 380 HIS A N   1 
ATOM 2272 C CA  . HIS A 1 340 ? 215.798 220.540 199.441 1.00 75.42  ? 380 HIS A CA  1 
ATOM 2273 C C   . HIS A 1 340 ? 215.745 219.585 200.625 1.00 79.88  ? 380 HIS A C   1 
ATOM 2274 O O   . HIS A 1 340 ? 216.196 219.907 201.728 1.00 86.58  ? 380 HIS A O   1 
ATOM 2275 C CB  . HIS A 1 340 ? 217.045 220.248 198.597 1.00 73.93  ? 380 HIS A CB  1 
ATOM 2276 C CG  . HIS A 1 340 ? 217.099 218.851 198.065 1.00 76.96  ? 380 HIS A CG  1 
ATOM 2277 N ND1 . HIS A 1 340 ? 218.127 217.982 198.357 1.00 78.80  ? 380 HIS A ND1 1 
ATOM 2278 C CD2 . HIS A 1 340 ? 216.246 218.168 197.265 1.00 79.64  ? 380 HIS A CD2 1 
ATOM 2279 C CE1 . HIS A 1 340 ? 217.908 216.826 197.758 1.00 78.41  ? 380 HIS A CE1 1 
ATOM 2280 N NE2 . HIS A 1 340 ? 216.773 216.912 197.088 1.00 81.13  ? 380 HIS A NE2 1 
ATOM 2281 N N   . GLY A 1 341 ? 215.183 218.401 200.377 1.00 74.58  ? 381 GLY A N   1 
ATOM 2282 C CA  . GLY A 1 341 ? 215.166 217.319 201.338 1.00 73.98  ? 381 GLY A CA  1 
ATOM 2283 C C   . GLY A 1 341 ? 214.201 217.559 202.486 1.00 80.39  ? 381 GLY A C   1 
ATOM 2284 O O   . GLY A 1 341 ? 213.307 218.406 202.431 1.00 87.44  ? 381 GLY A O   1 
ATOM 2285 N N   . GLY A 1 342 ? 214.394 216.782 203.542 1.00 78.90  ? 382 GLY A N   1 
ATOM 2286 C CA  . GLY A 1 342 ? 213.641 216.934 204.770 1.00 78.25  ? 382 GLY A CA  1 
ATOM 2287 C C   . GLY A 1 342 ? 212.721 215.754 205.027 1.00 79.95  ? 382 GLY A C   1 
ATOM 2288 O O   . GLY A 1 342 ? 212.686 214.772 204.284 1.00 80.31  ? 382 GLY A O   1 
ATOM 2289 N N   . VAL A 1 343 ? 211.967 215.879 206.115 1.00 81.64  ? 383 VAL A N   1 
ATOM 2290 C CA  . VAL A 1 343 ? 211.005 214.874 206.547 1.00 80.49  ? 383 VAL A CA  1 
ATOM 2291 C C   . VAL A 1 343 ? 209.615 215.482 206.450 1.00 83.46  ? 383 VAL A C   1 
ATOM 2292 O O   . VAL A 1 343 ? 209.359 216.547 207.021 1.00 88.07  ? 383 VAL A O   1 
ATOM 2293 C CB  . VAL A 1 343 ? 211.294 214.395 207.980 1.00 78.65  ? 383 VAL A CB  1 
ATOM 2294 C CG1 . VAL A 1 343 ? 210.180 213.493 208.471 1.00 84.31  ? 383 VAL A CG1 1 
ATOM 2295 C CG2 . VAL A 1 343 ? 212.631 213.681 208.037 1.00 81.55  ? 383 VAL A CG2 1 
ATOM 2296 N N   . VAL A 1 344 ? 208.722 214.808 205.731 1.00 80.41  ? 384 VAL A N   1 
ATOM 2297 C CA  . VAL A 1 344 ? 207.391 215.352 205.483 1.00 79.70  ? 384 VAL A CA  1 
ATOM 2298 C C   . VAL A 1 344 ? 206.393 214.897 206.539 1.00 88.00  ? 384 VAL A C   1 
ATOM 2299 O O   . VAL A 1 344 ? 205.592 215.698 207.026 1.00 97.34  ? 384 VAL A O   1 
ATOM 2300 C CB  . VAL A 1 344 ? 206.925 214.969 204.066 1.00 79.22  ? 384 VAL A CB  1 
ATOM 2301 C CG1 . VAL A 1 344 ? 205.456 215.302 203.884 1.00 82.01  ? 384 VAL A CG1 1 
ATOM 2302 C CG2 . VAL A 1 344 ? 207.759 215.688 203.033 1.00 79.91  ? 384 VAL A CG2 1 
ATOM 2303 N N   . ASN A 1 345 ? 206.416 213.622 206.910 1.00 87.64  ? 385 ASN A N   1 
ATOM 2304 C CA  . ASN A 1 345 ? 205.493 213.074 207.894 1.00 93.69  ? 385 ASN A CA  1 
ATOM 2305 C C   . ASN A 1 345 ? 206.244 212.765 209.180 1.00 96.26  ? 385 ASN A C   1 
ATOM 2306 O O   . ASN A 1 345 ? 207.293 212.114 209.150 1.00 96.72  ? 385 ASN A O   1 
ATOM 2307 C CB  . ASN A 1 345 ? 204.810 211.813 207.365 1.00 98.82  ? 385 ASN A CB  1 
ATOM 2308 C CG  . ASN A 1 345 ? 203.562 211.462 208.144 1.00 104.31 ? 385 ASN A CG  1 
ATOM 2309 O OD1 . ASN A 1 345 ? 203.624 210.770 209.159 1.00 105.52 ? 385 ASN A OD1 1 
ATOM 2310 N ND2 . ASN A 1 345 ? 202.418 211.945 207.674 1.00 105.11 ? 385 ASN A ND2 1 
ATOM 2311 N N   . ILE A 1 346 ? 205.703 213.230 210.306 1.00 95.44  ? 386 ILE A N   1 
ATOM 2312 C CA  . ILE A 1 346 ? 206.353 213.016 211.593 1.00 96.69  ? 386 ILE A CA  1 
ATOM 2313 C C   . ILE A 1 346 ? 205.962 211.692 212.238 1.00 98.59  ? 386 ILE A C   1 
ATOM 2314 O O   . ILE A 1 346 ? 206.698 211.196 213.103 1.00 99.66  ? 386 ILE A O   1 
ATOM 2315 C CB  . ILE A 1 346 ? 206.050 214.183 212.550 1.00 98.06  ? 386 ILE A CB  1 
ATOM 2316 C CG1 . ILE A 1 346 ? 207.194 214.372 213.545 1.00 94.93  ? 386 ILE A CG1 1 
ATOM 2317 C CG2 . ILE A 1 346 ? 204.735 213.960 213.281 1.00 101.64 ? 386 ILE A CG2 1 
ATOM 2318 C CD1 . ILE A 1 346 ? 206.956 215.491 214.528 1.00 92.44  ? 386 ILE A CD1 1 
ATOM 2319 N N   . HIS A 1 347 ? 204.835 211.103 211.843 1.00 97.70  ? 387 HIS A N   1 
ATOM 2320 C CA  . HIS A 1 347 ? 204.399 209.818 212.374 1.00 99.14  ? 387 HIS A CA  1 
ATOM 2321 C C   . HIS A 1 347 ? 204.828 208.656 211.489 1.00 104.13 ? 387 HIS A C   1 
ATOM 2322 O O   . HIS A 1 347 ? 205.332 207.647 211.990 1.00 106.71 ? 387 HIS A O   1 
ATOM 2323 C CB  . HIS A 1 347 ? 202.876 209.807 212.550 1.00 96.49  ? 387 HIS A CB  1 
ATOM 2324 N N   . GLU A 1 348 ? 204.641 208.781 210.176 1.00 104.55 ? 388 GLU A N   1 
ATOM 2325 C CA  . GLU A 1 348 ? 205.089 207.755 209.246 1.00 102.87 ? 388 GLU A CA  1 
ATOM 2326 C C   . GLU A 1 348 ? 206.581 207.830 208.962 1.00 99.29  ? 388 GLU A C   1 
ATOM 2327 O O   . GLU A 1 348 ? 207.124 206.895 208.364 1.00 99.47  ? 388 GLU A O   1 
ATOM 2328 C CB  . GLU A 1 348 ? 204.317 207.863 207.930 1.00 103.57 ? 388 GLU A CB  1 
ATOM 2329 C CG  . GLU A 1 348 ? 202.845 207.516 208.041 1.00 106.52 ? 388 GLU A CG  1 
ATOM 2330 C CD  . GLU A 1 348 ? 202.147 207.520 206.697 1.00 114.75 ? 388 GLU A CD  1 
ATOM 2331 O OE1 . GLU A 1 348 ? 202.778 207.928 205.700 1.00 115.23 ? 388 GLU A OE1 1 
ATOM 2332 O OE2 . GLU A 1 348 ? 200.967 207.116 206.638 1.00 120.40 ? 388 GLU A OE2 1 
ATOM 2333 N N   . ASN A 1 349 ? 207.246 208.910 209.376 1.00 98.98  ? 389 ASN A N   1 
ATOM 2334 C CA  . ASN A 1 349 ? 208.669 209.120 209.112 1.00 96.78  ? 389 ASN A CA  1 
ATOM 2335 C C   . ASN A 1 349 ? 208.955 209.068 207.613 1.00 96.12  ? 389 ASN A C   1 
ATOM 2336 O O   . ASN A 1 349 ? 209.770 208.276 207.136 1.00 99.67  ? 389 ASN A O   1 
ATOM 2337 C CB  . ASN A 1 349 ? 209.527 208.109 209.876 1.00 98.31  ? 389 ASN A CB  1 
ATOM 2338 C CG  . ASN A 1 349 ? 210.934 208.608 210.117 1.00 105.50 ? 389 ASN A CG  1 
ATOM 2339 O OD1 . ASN A 1 349 ? 211.704 208.806 209.179 1.00 105.53 ? 389 ASN A OD1 1 
ATOM 2340 N ND2 . ASN A 1 349 ? 211.277 208.817 211.381 1.00 115.12 ? 389 ASN A ND2 1 
ATOM 2341 N N   . LYS A 1 350 ? 208.271 209.929 206.866 1.00 89.55  ? 390 LYS A N   1 
ATOM 2342 C CA  . LYS A 1 350 ? 208.359 209.955 205.414 1.00 84.72  ? 390 LYS A CA  1 
ATOM 2343 C C   . LYS A 1 350 ? 209.222 211.126 204.969 1.00 86.01  ? 390 LYS A C   1 
ATOM 2344 O O   . LYS A 1 350 ? 208.996 212.265 205.390 1.00 89.36  ? 390 LYS A O   1 
ATOM 2345 C CB  . LYS A 1 350 ? 206.967 210.058 204.792 1.00 86.83  ? 390 LYS A CB  1 
ATOM 2346 C CG  . LYS A 1 350 ? 206.966 210.109 203.277 1.00 90.39  ? 390 LYS A CG  1 
ATOM 2347 C CD  . LYS A 1 350 ? 205.557 209.973 202.727 1.00 93.64  ? 390 LYS A CD  1 
ATOM 2348 C CE  . LYS A 1 350 ? 205.264 211.045 201.693 1.00 97.14  ? 390 LYS A CE  1 
ATOM 2349 N NZ  . LYS A 1 350 ? 206.422 211.273 200.787 1.00 100.01 ? 390 LYS A NZ  1 
ATOM 2350 N N   . ARG A 1 351 ? 210.203 210.843 204.120 1.00 83.21  ? 391 ARG A N   1 
ATOM 2351 C CA  . ARG A 1 351 ? 211.106 211.854 203.598 1.00 81.73  ? 391 ARG A CA  1 
ATOM 2352 C C   . ARG A 1 351 ? 210.655 212.282 202.204 1.00 83.76  ? 391 ARG A C   1 
ATOM 2353 O O   . ARG A 1 351 ? 209.653 211.804 201.669 1.00 84.12  ? 391 ARG A O   1 
ATOM 2354 C CB  . ARG A 1 351 ? 212.540 211.325 203.580 1.00 82.80  ? 391 ARG A CB  1 
ATOM 2355 C CG  . ARG A 1 351 ? 213.316 211.629 204.844 1.00 82.16  ? 391 ARG A CG  1 
ATOM 2356 C CD  . ARG A 1 351 ? 214.344 210.556 205.137 1.00 80.19  ? 391 ARG A CD  1 
ATOM 2357 N NE  . ARG A 1 351 ? 214.753 210.579 206.535 1.00 82.61  ? 391 ARG A NE  1 
ATOM 2358 C CZ  . ARG A 1 351 ? 214.090 209.983 207.515 1.00 89.13  ? 391 ARG A CZ  1 
ATOM 2359 N NH1 . ARG A 1 351 ? 212.990 209.288 207.281 1.00 92.87  ? 391 ARG A NH1 1 
ATOM 2360 N NH2 . ARG A 1 351 ? 214.542 210.085 208.760 1.00 90.81  ? 391 ARG A NH2 1 
ATOM 2361 N N   . THR A 1 352 ? 211.413 213.198 201.607 1.00 84.09  ? 392 THR A N   1 
ATOM 2362 C CA  . THR A 1 352 ? 211.073 213.725 200.295 1.00 83.78  ? 392 THR A CA  1 
ATOM 2363 C C   . THR A 1 352 ? 212.342 214.144 199.572 1.00 84.48  ? 392 THR A C   1 
ATOM 2364 O O   . THR A 1 352 ? 213.400 214.319 200.180 1.00 86.12  ? 392 THR A O   1 
ATOM 2365 C CB  . THR A 1 352 ? 210.113 214.914 200.392 1.00 87.25  ? 392 THR A CB  1 
ATOM 2366 O OG1 . THR A 1 352 ? 209.673 215.281 199.080 1.00 91.17  ? 392 THR A OG1 1 
ATOM 2367 C CG2 . THR A 1 352 ? 210.808 216.102 201.033 1.00 81.89  ? 392 THR A CG2 1 
ATOM 2368 N N   . GLY A 1 353 ? 212.221 214.298 198.258 1.00 87.15  ? 393 GLY A N   1 
ATOM 2369 C CA  . GLY A 1 353 ? 213.321 214.773 197.445 1.00 87.54  ? 393 GLY A CA  1 
ATOM 2370 C C   . GLY A 1 353 ? 212.942 216.001 196.647 1.00 87.19  ? 393 GLY A C   1 
ATOM 2371 O O   . GLY A 1 353 ? 213.663 216.407 195.731 1.00 86.61  ? 393 GLY A O   1 
ATOM 2372 N N   . SER A 1 354 ? 211.804 216.599 196.990 1.00 87.29  ? 394 SER A N   1 
ATOM 2373 C CA  . SER A 1 354 ? 211.328 217.775 196.279 1.00 84.31  ? 394 SER A CA  1 
ATOM 2374 C C   . SER A 1 354 ? 212.246 218.964 196.525 1.00 78.80  ? 394 SER A C   1 
ATOM 2375 O O   . SER A 1 354 ? 212.708 219.193 197.646 1.00 77.35  ? 394 SER A O   1 
ATOM 2376 C CB  . SER A 1 354 ? 209.904 218.115 196.713 1.00 87.12  ? 394 SER A CB  1 
ATOM 2377 O OG  . SER A 1 354 ? 208.965 217.246 196.105 1.00 89.52  ? 394 SER A OG  1 
ATOM 2378 N N   . LEU A 1 355 ? 212.506 219.724 195.467 1.00 76.50  ? 395 LEU A N   1 
ATOM 2379 C CA  . LEU A 1 355 ? 213.332 220.920 195.531 1.00 74.08  ? 395 LEU A CA  1 
ATOM 2380 C C   . LEU A 1 355 ? 212.471 222.134 195.218 1.00 78.88  ? 395 LEU A C   1 
ATOM 2381 O O   . LEU A 1 355 ? 211.724 222.132 194.235 1.00 83.41  ? 395 LEU A O   1 
ATOM 2382 C CB  . LEU A 1 355 ? 214.501 220.832 194.551 1.00 67.47  ? 395 LEU A CB  1 
ATOM 2383 C CG  . LEU A 1 355 ? 215.208 222.147 194.232 1.00 65.54  ? 395 LEU A CG  1 
ATOM 2384 C CD1 . LEU A 1 355 ? 216.131 222.545 195.365 1.00 72.44  ? 395 LEU A CD1 1 
ATOM 2385 C CD2 . LEU A 1 355 ? 215.981 222.023 192.938 1.00 74.54  ? 395 LEU A CD2 1 
ATOM 2386 N N   . PHE A 1 356 ? 212.571 223.162 196.055 1.00 77.67  ? 396 PHE A N   1 
ATOM 2387 C CA  . PHE A 1 356 ? 211.773 224.368 195.901 1.00 79.81  ? 396 PHE A CA  1 
ATOM 2388 C C   . PHE A 1 356 ? 212.684 225.583 195.847 1.00 79.88  ? 396 PHE A C   1 
ATOM 2389 O O   . PHE A 1 356 ? 213.758 225.602 196.450 1.00 82.46  ? 396 PHE A O   1 
ATOM 2390 C CB  . PHE A 1 356 ? 210.771 224.530 197.047 1.00 84.31  ? 396 PHE A CB  1 
ATOM 2391 C CG  . PHE A 1 356 ? 209.777 223.413 197.145 1.00 86.07  ? 396 PHE A CG  1 
ATOM 2392 C CD1 . PHE A 1 356 ? 208.612 223.437 196.400 1.00 89.65  ? 396 PHE A CD1 1 
ATOM 2393 C CD2 . PHE A 1 356 ? 210.003 222.341 197.988 1.00 83.83  ? 396 PHE A CD2 1 
ATOM 2394 C CE1 . PHE A 1 356 ? 207.694 222.412 196.492 1.00 89.83  ? 396 PHE A CE1 1 
ATOM 2395 C CE2 . PHE A 1 356 ? 209.089 221.314 198.084 1.00 87.96  ? 396 PHE A CE2 1 
ATOM 2396 C CZ  . PHE A 1 356 ? 207.933 221.350 197.334 1.00 92.49  ? 396 PHE A CZ  1 
ATOM 2397 N N   . LYS A 1 357 ? 212.244 226.600 195.115 1.00 80.98  ? 397 LYS A N   1 
ATOM 2398 C CA  . LYS A 1 357 ? 212.960 227.861 195.026 1.00 83.54  ? 397 LYS A CA  1 
ATOM 2399 C C   . LYS A 1 357 ? 211.989 229.005 195.272 1.00 92.36  ? 397 LYS A C   1 
ATOM 2400 O O   . LYS A 1 357 ? 210.797 228.909 194.966 1.00 97.78  ? 397 LYS A O   1 
ATOM 2401 C CB  . LYS A 1 357 ? 213.653 228.027 193.665 1.00 84.15  ? 397 LYS A CB  1 
ATOM 2402 C CG  . LYS A 1 357 ? 212.731 228.421 192.526 1.00 90.85  ? 397 LYS A CG  1 
ATOM 2403 C CD  . LYS A 1 357 ? 213.527 228.864 191.310 1.00 92.08  ? 397 LYS A CD  1 
ATOM 2404 C CE  . LYS A 1 357 ? 212.643 229.569 190.296 1.00 94.95  ? 397 LYS A CE  1 
ATOM 2405 N NZ  . LYS A 1 357 ? 212.416 230.995 190.655 1.00 97.05  ? 397 LYS A NZ  1 
ATOM 2406 N N   . ILE A 1 358 ? 212.512 230.087 195.847 1.00 90.46  ? 398 ILE A N   1 
ATOM 2407 C CA  . ILE A 1 358 ? 211.694 231.240 196.199 1.00 90.15  ? 398 ILE A CA  1 
ATOM 2408 C C   . ILE A 1 358 ? 212.554 232.492 196.100 1.00 95.74  ? 398 ILE A C   1 
ATOM 2409 O O   . ILE A 1 358 ? 213.769 232.449 196.303 1.00 96.35  ? 398 ILE A O   1 
ATOM 2410 C CB  . ILE A 1 358 ? 211.078 231.077 197.609 1.00 90.48  ? 398 ILE A CB  1 
ATOM 2411 C CG1 . ILE A 1 358 ? 210.046 232.170 197.885 1.00 100.11 ? 398 ILE A CG1 1 
ATOM 2412 C CG2 . ILE A 1 358 ? 212.162 231.069 198.671 1.00 89.80  ? 398 ILE A CG2 1 
ATOM 2413 C CD1 . ILE A 1 358 ? 209.556 232.198 199.311 1.00 101.77 ? 398 ILE A CD1 1 
ATOM 2414 N N   . TRP A 1 359 ? 211.921 233.611 195.761 1.00 98.48  ? 399 TRP A N   1 
ATOM 2415 C CA  . TRP A 1 359 ? 212.599 234.897 195.670 1.00 97.17  ? 399 TRP A CA  1 
ATOM 2416 C C   . TRP A 1 359 ? 212.262 235.718 196.907 1.00 95.45  ? 399 TRP A C   1 
ATOM 2417 O O   . TRP A 1 359 ? 211.093 236.037 197.146 1.00 99.51  ? 399 TRP A O   1 
ATOM 2418 C CB  . TRP A 1 359 ? 212.190 235.643 194.400 1.00 98.47  ? 399 TRP A CB  1 
ATOM 2419 C CG  . TRP A 1 359 ? 212.980 235.245 193.200 1.00 94.30  ? 399 TRP A CG  1 
ATOM 2420 C CD1 . TRP A 1 359 ? 212.584 234.410 192.200 1.00 96.54  ? 399 TRP A CD1 1 
ATOM 2421 C CD2 . TRP A 1 359 ? 214.310 235.661 192.873 1.00 93.22  ? 399 TRP A CD2 1 
ATOM 2422 N NE1 . TRP A 1 359 ? 213.583 234.280 191.268 1.00 95.83  ? 399 TRP A NE1 1 
ATOM 2423 C CE2 . TRP A 1 359 ? 214.654 235.039 191.659 1.00 94.01  ? 399 TRP A CE2 1 
ATOM 2424 C CE3 . TRP A 1 359 ? 215.242 236.499 193.489 1.00 93.94  ? 399 TRP A CE3 1 
ATOM 2425 C CZ2 . TRP A 1 359 ? 215.890 235.228 191.049 1.00 92.64  ? 399 TRP A CZ2 1 
ATOM 2426 C CZ3 . TRP A 1 359 ? 216.468 236.686 192.882 1.00 92.31  ? 399 TRP A CZ3 1 
ATOM 2427 C CH2 . TRP A 1 359 ? 216.781 236.054 191.675 1.00 89.78  ? 399 TRP A CH2 1 
ATOM 2428 N N   . LEU A 1 360 ? 213.284 236.064 197.686 1.00 89.09  ? 400 LEU A N   1 
ATOM 2429 C CA  . LEU A 1 360 ? 213.070 236.774 198.939 1.00 90.37  ? 400 LEU A CA  1 
ATOM 2430 C C   . LEU A 1 360 ? 213.155 238.285 198.790 1.00 92.80  ? 400 LEU A C   1 
ATOM 2431 O O   . LEU A 1 360 ? 212.560 239.012 199.593 1.00 92.66  ? 400 LEU A O   1 
ATOM 2432 C CB  . LEU A 1 360 ? 214.083 236.305 199.984 1.00 90.95  ? 400 LEU A CB  1 
ATOM 2433 C CG  . LEU A 1 360 ? 214.047 234.807 200.283 1.00 93.64  ? 400 LEU A CG  1 
ATOM 2434 C CD1 . LEU A 1 360 ? 215.278 234.390 201.063 1.00 94.33  ? 400 LEU A CD1 1 
ATOM 2435 C CD2 . LEU A 1 360 ? 212.781 234.442 201.035 1.00 91.17  ? 400 LEU A CD2 1 
ATOM 2436 N N   . VAL A 1 361 ? 213.879 238.775 197.785 1.00 94.58  ? 401 VAL A N   1 
ATOM 2437 C CA  . VAL A 1 361 ? 214.005 240.200 197.522 1.00 92.35  ? 401 VAL A CA  1 
ATOM 2438 C C   . VAL A 1 361 ? 213.689 240.446 196.054 1.00 93.40  ? 401 VAL A C   1 
ATOM 2439 O O   . VAL A 1 361 ? 213.555 239.516 195.259 1.00 97.22  ? 401 VAL A O   1 
ATOM 2440 C CB  . VAL A 1 361 ? 215.405 240.741 197.871 1.00 91.01  ? 401 VAL A CB  1 
ATOM 2441 C CG1 . VAL A 1 361 ? 215.629 240.700 199.371 1.00 93.37  ? 401 VAL A CG1 1 
ATOM 2442 C CG2 . VAL A 1 361 ? 216.474 239.945 197.144 1.00 89.43  ? 401 VAL A CG2 1 
ATOM 2443 N N   . VAL A 1 362 ? 213.566 241.721 195.700 1.00 93.26  ? 402 VAL A N   1 
ATOM 2444 C CA  . VAL A 1 362 ? 213.319 242.095 194.311 1.00 89.92  ? 402 VAL A CA  1 
ATOM 2445 C C   . VAL A 1 362 ? 214.590 241.821 193.518 1.00 92.52  ? 402 VAL A C   1 
ATOM 2446 O O   . VAL A 1 362 ? 215.649 242.384 193.832 1.00 96.53  ? 402 VAL A O   1 
ATOM 2447 C CB  . VAL A 1 362 ? 212.890 243.564 194.189 1.00 84.03  ? 402 VAL A CB  1 
ATOM 2448 C CG1 . VAL A 1 362 ? 212.614 243.907 192.739 1.00 89.00  ? 402 VAL A CG1 1 
ATOM 2449 C CG2 . VAL A 1 362 ? 211.664 243.829 195.041 1.00 83.15  ? 402 VAL A CG2 1 
ATOM 2450 N N   . PRO A 1 363 ? 214.539 240.970 192.498 1.00 91.39  ? 403 PRO A N   1 
ATOM 2451 C CA  . PRO A 1 363 ? 215.761 240.627 191.767 1.00 91.40  ? 403 PRO A CA  1 
ATOM 2452 C C   . PRO A 1 363 ? 216.273 241.800 190.951 1.00 93.60  ? 403 PRO A C   1 
ATOM 2453 O O   . PRO A 1 363 ? 215.521 242.699 190.567 1.00 97.96  ? 403 PRO A O   1 
ATOM 2454 C CB  . PRO A 1 363 ? 215.324 239.470 190.857 1.00 94.00  ? 403 PRO A CB  1 
ATOM 2455 C CG  . PRO A 1 363 ? 213.956 239.068 191.332 1.00 94.69  ? 403 PRO A CG  1 
ATOM 2456 C CD  . PRO A 1 363 ? 213.360 240.278 191.960 1.00 93.23  ? 403 PRO A CD  1 
ATOM 2457 N N   . SER A 1 364 ? 217.576 241.786 190.692 1.00 92.72  ? 404 SER A N   1 
ATOM 2458 C CA  . SER A 1 364 ? 218.158 242.786 189.815 1.00 94.17  ? 404 SER A CA  1 
ATOM 2459 C C   . SER A 1 364 ? 217.683 242.565 188.383 1.00 93.16  ? 404 SER A C   1 
ATOM 2460 O O   . SER A 1 364 ? 217.264 241.469 188.001 1.00 94.50  ? 404 SER A O   1 
ATOM 2461 C CB  . SER A 1 364 ? 219.684 242.740 189.881 1.00 97.32  ? 404 SER A CB  1 
ATOM 2462 O OG  . SER A 1 364 ? 220.153 241.406 189.932 1.00 100.31 ? 404 SER A OG  1 
ATOM 2463 N N   . LEU A 1 365 ? 217.738 243.637 187.589 1.00 92.38  ? 405 LEU A N   1 
ATOM 2464 C CA  . LEU A 1 365 ? 217.309 243.544 186.198 1.00 94.50  ? 405 LEU A CA  1 
ATOM 2465 C C   . LEU A 1 365 ? 218.108 242.495 185.441 1.00 92.36  ? 405 LEU A C   1 
ATOM 2466 O O   . LEU A 1 365 ? 217.568 241.818 184.557 1.00 94.88  ? 405 LEU A O   1 
ATOM 2467 C CB  . LEU A 1 365 ? 217.438 244.904 185.516 1.00 93.34  ? 405 LEU A CB  1 
ATOM 2468 C CG  . LEU A 1 365 ? 216.727 245.074 184.174 1.00 93.84  ? 405 LEU A CG  1 
ATOM 2469 C CD1 . LEU A 1 365 ? 215.388 244.357 184.173 1.00 94.00  ? 405 LEU A CD1 1 
ATOM 2470 C CD2 . LEU A 1 365 ? 216.548 246.549 183.861 1.00 96.63  ? 405 LEU A CD2 1 
ATOM 2471 N N   . LEU A 1 366 ? 219.387 242.339 185.783 1.00 87.37  ? 406 LEU A N   1 
ATOM 2472 C CA  . LEU A 1 366 ? 220.202 241.296 185.173 1.00 89.17  ? 406 LEU A CA  1 
ATOM 2473 C C   . LEU A 1 366 ? 219.612 239.917 185.439 1.00 92.63  ? 406 LEU A C   1 
ATOM 2474 O O   . LEU A 1 366 ? 219.509 239.089 184.529 1.00 94.36  ? 406 LEU A O   1 
ATOM 2475 C CB  . LEU A 1 366 ? 221.634 241.387 185.700 1.00 88.52  ? 406 LEU A CB  1 
ATOM 2476 C CG  . LEU A 1 366 ? 222.479 240.115 185.709 1.00 88.43  ? 406 LEU A CG  1 
ATOM 2477 C CD1 . LEU A 1 366 ? 222.956 239.775 184.314 1.00 86.84  ? 406 LEU A CD1 1 
ATOM 2478 C CD2 . LEU A 1 366 ? 223.658 240.272 186.654 1.00 89.56  ? 406 LEU A CD2 1 
ATOM 2479 N N   . GLU A 1 367 ? 219.197 239.660 186.682 1.00 92.53  ? 407 GLU A N   1 
ATOM 2480 C CA  . GLU A 1 367 ? 218.645 238.352 187.021 1.00 89.10  ? 407 GLU A CA  1 
ATOM 2481 C C   . GLU A 1 367 ? 217.320 238.099 186.313 1.00 88.92  ? 407 GLU A C   1 
ATOM 2482 O O   . GLU A 1 367 ? 217.084 236.996 185.806 1.00 91.17  ? 407 GLU A O   1 
ATOM 2483 C CB  . GLU A 1 367 ? 218.474 238.230 188.534 1.00 88.64  ? 407 GLU A CB  1 
ATOM 2484 C CG  . GLU A 1 367 ? 219.775 238.291 189.313 1.00 89.98  ? 407 GLU A CG  1 
ATOM 2485 C CD  . GLU A 1 367 ? 220.817 237.323 188.791 1.00 93.77  ? 407 GLU A CD  1 
ATOM 2486 O OE1 . GLU A 1 367 ? 220.481 236.139 188.586 1.00 99.57  ? 407 GLU A OE1 1 
ATOM 2487 O OE2 . GLU A 1 367 ? 221.974 237.746 188.587 1.00 91.95  ? 407 GLU A OE2 1 
ATOM 2488 N N   . LEU A 1 368 ? 216.438 239.100 186.276 1.00 89.44  ? 408 LEU A N   1 
ATOM 2489 C CA  . LEU A 1 368 ? 215.156 238.930 185.600 1.00 88.23  ? 408 LEU A CA  1 
ATOM 2490 C C   . LEU A 1 368 ? 215.355 238.668 184.115 1.00 92.54  ? 408 LEU A C   1 
ATOM 2491 O O   . LEU A 1 368 ? 214.724 237.772 183.536 1.00 100.31 ? 408 LEU A O   1 
ATOM 2492 C CB  . LEU A 1 368 ? 214.283 240.167 185.812 1.00 87.41  ? 408 LEU A CB  1 
ATOM 2493 C CG  . LEU A 1 368 ? 213.827 240.461 187.239 1.00 88.30  ? 408 LEU A CG  1 
ATOM 2494 C CD1 . LEU A 1 368 ? 213.073 241.776 187.294 1.00 83.70  ? 408 LEU A CD1 1 
ATOM 2495 C CD2 . LEU A 1 368 ? 212.966 239.328 187.761 1.00 95.84  ? 408 LEU A CD2 1 
ATOM 2496 N N   . ALA A 1 369 ? 216.238 239.442 183.480 1.00 88.68  ? 409 ALA A N   1 
ATOM 2497 C CA  . ALA A 1 369 ? 216.518 239.232 182.066 1.00 88.51  ? 409 ALA A CA  1 
ATOM 2498 C C   . ALA A 1 369 ? 217.121 237.856 181.827 1.00 95.31  ? 409 ALA A C   1 
ATOM 2499 O O   . ALA A 1 369 ? 216.781 237.185 180.848 1.00 97.75  ? 409 ALA A O   1 
ATOM 2500 C CB  . ALA A 1 369 ? 217.449 240.326 181.548 1.00 88.34  ? 409 ALA A CB  1 
ATOM 2501 N N   . TRP A 1 370 ? 218.016 237.419 182.715 1.00 95.47  ? 410 TRP A N   1 
ATOM 2502 C CA  . TRP A 1 370 ? 218.637 236.107 182.572 1.00 91.18  ? 410 TRP A CA  1 
ATOM 2503 C C   . TRP A 1 370 ? 217.601 234.996 182.659 1.00 93.81  ? 410 TRP A C   1 
ATOM 2504 O O   . TRP A 1 370 ? 217.597 234.068 181.841 1.00 95.92  ? 410 TRP A O   1 
ATOM 2505 C CB  . TRP A 1 370 ? 219.709 235.936 183.646 1.00 87.94  ? 410 TRP A CB  1 
ATOM 2506 C CG  . TRP A 1 370 ? 220.521 234.699 183.515 1.00 90.87  ? 410 TRP A CG  1 
ATOM 2507 C CD1 . TRP A 1 370 ? 220.645 233.703 184.435 1.00 94.29  ? 410 TRP A CD1 1 
ATOM 2508 C CD2 . TRP A 1 370 ? 221.341 234.325 182.404 1.00 98.10  ? 410 TRP A CD2 1 
ATOM 2509 N NE1 . TRP A 1 370 ? 221.488 232.728 183.965 1.00 100.57 ? 410 TRP A NE1 1 
ATOM 2510 C CE2 . TRP A 1 370 ? 221.928 233.086 182.719 1.00 101.57 ? 410 TRP A CE2 1 
ATOM 2511 C CE3 . TRP A 1 370 ? 221.632 234.916 181.172 1.00 100.47 ? 410 TRP A CE3 1 
ATOM 2512 C CZ2 . TRP A 1 370 ? 222.788 232.428 181.848 1.00 101.99 ? 410 TRP A CZ2 1 
ATOM 2513 C CZ3 . TRP A 1 370 ? 222.487 234.261 180.309 1.00 98.89  ? 410 TRP A CZ3 1 
ATOM 2514 C CH2 . TRP A 1 370 ? 223.055 233.031 180.651 1.00 100.16 ? 410 TRP A CH2 1 
ATOM 2515 N N   . GLU A 1 371 ? 216.703 235.081 183.643 1.00 96.07  ? 411 GLU A N   1 
ATOM 2516 C CA  . GLU A 1 371 ? 215.665 234.066 183.783 1.00 94.03  ? 411 GLU A CA  1 
ATOM 2517 C C   . GLU A 1 371 ? 214.748 234.043 182.568 1.00 93.24  ? 411 GLU A C   1 
ATOM 2518 O O   . GLU A 1 371 ? 214.423 232.969 182.047 1.00 95.56  ? 411 GLU A O   1 
ATOM 2519 C CB  . GLU A 1 371 ? 214.858 234.308 185.057 1.00 96.14  ? 411 GLU A CB  1 
ATOM 2520 C CG  . GLU A 1 371 ? 215.673 234.239 186.334 1.00 103.64 ? 411 GLU A CG  1 
ATOM 2521 C CD  . GLU A 1 371 ? 215.602 232.880 186.996 1.00 114.54 ? 411 GLU A CD  1 
ATOM 2522 O OE1 . GLU A 1 371 ? 214.635 232.137 186.727 1.00 110.71 ? 411 GLU A OE1 1 
ATOM 2523 O OE2 . GLU A 1 371 ? 216.512 232.554 187.787 1.00 120.18 ? 411 GLU A OE2 1 
ATOM 2524 N N   . LYS A 1 372 ? 214.325 235.220 182.097 1.00 93.73  ? 412 LYS A N   1 
ATOM 2525 C CA  . LYS A 1 372 ? 213.429 235.260 180.946 1.00 94.25  ? 412 LYS A CA  1 
ATOM 2526 C C   . LYS A 1 372 ? 214.111 234.720 179.696 1.00 94.35  ? 412 LYS A C   1 
ATOM 2527 O O   . LYS A 1 372 ? 213.496 233.985 178.915 1.00 97.15  ? 412 LYS A O   1 
ATOM 2528 C CB  . LYS A 1 372 ? 212.932 236.684 180.708 1.00 99.30  ? 412 LYS A CB  1 
ATOM 2529 C CG  . LYS A 1 372 ? 211.882 236.785 179.615 1.00 102.04 ? 412 LYS A CG  1 
ATOM 2530 C CD  . LYS A 1 372 ? 210.814 235.717 179.782 1.00 102.09 ? 412 LYS A CD  1 
ATOM 2531 C CE  . LYS A 1 372 ? 209.745 235.829 178.712 1.00 105.24 ? 412 LYS A CE  1 
ATOM 2532 N NZ  . LYS A 1 372 ? 208.624 234.882 178.952 1.00 110.85 ? 412 LYS A NZ  1 
ATOM 2533 N N   . LEU A 1 373 ? 215.380 235.074 179.487 1.00 93.66  ? 413 LEU A N   1 
ATOM 2534 C CA  . LEU A 1 373 ? 216.102 234.591 178.317 1.00 94.53  ? 413 LEU A CA  1 
ATOM 2535 C C   . LEU A 1 373 ? 216.292 233.082 178.369 1.00 98.51  ? 413 LEU A C   1 
ATOM 2536 O O   . LEU A 1 373 ? 216.141 232.398 177.350 1.00 101.62 ? 413 LEU A O   1 
ATOM 2537 C CB  . LEU A 1 373 ? 217.450 235.299 178.209 1.00 95.08  ? 413 LEU A CB  1 
ATOM 2538 C CG  . LEU A 1 373 ? 218.418 234.757 177.160 1.00 96.43  ? 413 LEU A CG  1 
ATOM 2539 C CD1 . LEU A 1 373 ? 217.872 234.996 175.767 1.00 101.41 ? 413 LEU A CD1 1 
ATOM 2540 C CD2 . LEU A 1 373 ? 219.785 235.394 177.318 1.00 97.86  ? 413 LEU A CD2 1 
ATOM 2541 N N   . LEU A 1 374 ? 216.627 232.544 179.544 1.00 99.59  ? 414 LEU A N   1 
ATOM 2542 C CA  . LEU A 1 374 ? 216.801 231.101 179.666 1.00 94.79  ? 414 LEU A CA  1 
ATOM 2543 C C   . LEU A 1 374 ? 215.488 230.364 179.436 1.00 97.30  ? 414 LEU A C   1 
ATOM 2544 O O   . LEU A 1 374 ? 215.466 229.319 178.777 1.00 98.88  ? 414 LEU A O   1 
ATOM 2545 C CB  . LEU A 1 374 ? 217.379 230.758 181.036 1.00 91.61  ? 414 LEU A CB  1 
ATOM 2546 C CG  . LEU A 1 374 ? 218.882 230.990 181.174 1.00 94.19  ? 414 LEU A CG  1 
ATOM 2547 C CD1 . LEU A 1 374 ? 219.365 230.552 182.542 1.00 98.79  ? 414 LEU A CD1 1 
ATOM 2548 C CD2 . LEU A 1 374 ? 219.631 230.259 180.077 1.00 91.20  ? 414 LEU A CD2 1 
ATOM 2549 N N   . ALA A 1 375 ? 214.385 230.887 179.976 1.00 99.45  ? 415 ALA A N   1 
ATOM 2550 C CA  . ALA A 1 375 ? 213.092 230.247 179.762 1.00 98.75  ? 415 ALA A CA  1 
ATOM 2551 C C   . ALA A 1 375 ? 212.673 230.310 178.298 1.00 97.93  ? 415 ALA A C   1 
ATOM 2552 O O   . ALA A 1 375 ? 212.150 229.330 177.754 1.00 99.44  ? 415 ALA A O   1 
ATOM 2553 C CB  . ALA A 1 375 ? 212.032 230.895 180.650 1.00 99.28  ? 415 ALA A CB  1 
ATOM 2554 N N   . ALA A 1 376 ? 212.896 231.451 177.643 1.00 98.65  ? 416 ALA A N   1 
ATOM 2555 C CA  . ALA A 1 376 ? 212.394 231.637 176.286 1.00 103.47 ? 416 ALA A CA  1 
ATOM 2556 C C   . ALA A 1 376 ? 213.161 230.792 175.276 1.00 106.71 ? 416 ALA A C   1 
ATOM 2557 O O   . ALA A 1 376 ? 212.570 230.267 174.326 1.00 110.31 ? 416 ALA A O   1 
ATOM 2558 C CB  . ALA A 1 376 ? 212.457 233.115 175.904 1.00 103.90 ? 416 ALA A CB  1 
ATOM 2559 N N   . PHE A 1 377 ? 214.471 230.646 175.460 1.00 105.55 ? 417 PHE A N   1 
ATOM 2560 C CA  . PHE A 1 377 ? 215.335 229.960 174.499 1.00 107.60 ? 417 PHE A CA  1 
ATOM 2561 C C   . PHE A 1 377 ? 216.111 228.867 175.217 1.00 111.64 ? 417 PHE A C   1 
ATOM 2562 O O   . PHE A 1 377 ? 217.277 229.056 175.590 1.00 114.45 ? 417 PHE A O   1 
ATOM 2563 C CB  . PHE A 1 377 ? 216.283 230.942 173.810 1.00 108.15 ? 417 PHE A CB  1 
ATOM 2564 C CG  . PHE A 1 377 ? 215.582 232.056 173.090 1.00 108.92 ? 417 PHE A CG  1 
ATOM 2565 C CD1 . PHE A 1 377 ? 214.481 231.798 172.292 1.00 111.29 ? 417 PHE A CD1 1 
ATOM 2566 C CD2 . PHE A 1 377 ? 216.025 233.361 173.209 1.00 107.22 ? 417 PHE A CD2 1 
ATOM 2567 C CE1 . PHE A 1 377 ? 213.835 232.821 171.628 1.00 114.15 ? 417 PHE A CE1 1 
ATOM 2568 C CE2 . PHE A 1 377 ? 215.383 234.388 172.548 1.00 110.84 ? 417 PHE A CE2 1 
ATOM 2569 C CZ  . PHE A 1 377 ? 214.287 234.118 171.756 1.00 115.19 ? 417 PHE A CZ  1 
ATOM 2570 N N   . PRO A 1 378 ? 215.492 227.704 175.431 1.00 111.93 ? 418 PRO A N   1 
ATOM 2571 C CA  . PRO A 1 378 ? 216.202 226.607 176.107 1.00 115.32 ? 418 PRO A CA  1 
ATOM 2572 C C   . PRO A 1 378 ? 217.406 226.095 175.342 1.00 118.57 ? 418 PRO A C   1 
ATOM 2573 O O   . PRO A 1 378 ? 218.319 225.532 175.959 1.00 121.07 ? 418 PRO A O   1 
ATOM 2574 C CB  . PRO A 1 378 ? 215.123 225.525 176.242 1.00 110.33 ? 418 PRO A CB  1 
ATOM 2575 C CG  . PRO A 1 378 ? 214.164 225.817 175.139 1.00 110.90 ? 418 PRO A CG  1 
ATOM 2576 C CD  . PRO A 1 378 ? 214.138 227.311 175.008 1.00 109.34 ? 418 PRO A CD  1 
ATOM 2577 N N   . ASN A 1 379 ? 217.446 226.272 174.020 1.00 115.62 ? 419 ASN A N   1 
ATOM 2578 C CA  . ASN A 1 379 ? 218.549 225.756 173.220 1.00 117.59 ? 419 ASN A CA  1 
ATOM 2579 C C   . ASN A 1 379 ? 219.850 226.516 173.439 1.00 119.79 ? 419 ASN A C   1 
ATOM 2580 O O   . ASN A 1 379 ? 220.891 226.076 172.941 1.00 122.11 ? 419 ASN A O   1 
ATOM 2581 C CB  . ASN A 1 379 ? 218.179 225.784 171.737 1.00 118.57 ? 419 ASN A CB  1 
ATOM 2582 C CG  . ASN A 1 379 ? 219.056 224.873 170.901 1.00 121.70 ? 419 ASN A CG  1 
ATOM 2583 O OD1 . ASN A 1 379 ? 219.190 223.685 171.192 1.00 124.22 ? 419 ASN A OD1 1 
ATOM 2584 N ND2 . ASN A 1 379 ? 219.661 225.427 169.858 1.00 116.74 ? 419 ASN A ND2 1 
ATOM 2585 N N   . LEU A 1 380 ? 219.814 227.640 174.162 1.00 118.62 ? 420 LEU A N   1 
ATOM 2586 C CA  . LEU A 1 380 ? 221.023 228.430 174.378 1.00 115.99 ? 420 LEU A CA  1 
ATOM 2587 C C   . LEU A 1 380 ? 222.137 227.605 175.006 1.00 115.78 ? 420 LEU A C   1 
ATOM 2588 O O   . LEU A 1 380 ? 223.317 227.845 174.728 1.00 115.68 ? 420 LEU A O   1 
ATOM 2589 C CB  . LEU A 1 380 ? 220.708 229.639 175.258 1.00 108.38 ? 420 LEU A CB  1 
ATOM 2590 C CG  . LEU A 1 380 ? 220.046 230.845 174.593 1.00 103.04 ? 420 LEU A CG  1 
ATOM 2591 C CD1 . LEU A 1 380 ? 220.366 232.107 175.369 1.00 104.00 ? 420 LEU A CD1 1 
ATOM 2592 C CD2 . LEU A 1 380 ? 220.489 230.979 173.150 1.00 104.03 ? 420 LEU A CD2 1 
ATOM 2593 N N   . ALA A 1 381 ? 221.789 226.633 175.850 1.00 113.58 ? 421 ALA A N   1 
ATOM 2594 C CA  . ALA A 1 381 ? 222.803 225.809 176.493 1.00 113.18 ? 421 ALA A CA  1 
ATOM 2595 C C   . ALA A 1 381 ? 223.582 224.960 175.498 1.00 116.52 ? 421 ALA A C   1 
ATOM 2596 O O   . ALA A 1 381 ? 224.724 224.585 175.784 1.00 118.44 ? 421 ALA A O   1 
ATOM 2597 C CB  . ALA A 1 381 ? 222.157 224.911 177.548 1.00 110.67 ? 421 ALA A CB  1 
ATOM 2598 N N   . ASN A 1 382 ? 222.998 224.650 174.340 1.00 116.76 ? 422 ASN A N   1 
ATOM 2599 C CA  . ASN A 1 382 ? 223.675 223.795 173.372 1.00 118.57 ? 422 ASN A CA  1 
ATOM 2600 C C   . ASN A 1 382 ? 224.768 224.533 172.609 1.00 119.80 ? 422 ASN A C   1 
ATOM 2601 O O   . ASN A 1 382 ? 225.751 223.911 172.193 1.00 120.81 ? 422 ASN A O   1 
ATOM 2602 C CB  . ASN A 1 382 ? 222.660 223.208 172.391 1.00 118.92 ? 422 ASN A CB  1 
ATOM 2603 N N   . LEU A 1 383 ? 224.618 225.840 172.412 1.00 121.15 ? 423 LEU A N   1 
ATOM 2604 C CA  . LEU A 1 383 ? 225.598 226.599 171.647 1.00 124.29 ? 423 LEU A CA  1 
ATOM 2605 C C   . LEU A 1 383 ? 226.915 226.703 172.406 1.00 126.86 ? 423 LEU A C   1 
ATOM 2606 O O   . LEU A 1 383 ? 226.937 226.792 173.636 1.00 126.97 ? 423 LEU A O   1 
ATOM 2607 C CB  . LEU A 1 383 ? 225.064 227.994 171.332 1.00 121.24 ? 423 LEU A CB  1 
ATOM 2608 C CG  . LEU A 1 383 ? 223.552 228.112 171.154 1.00 120.63 ? 423 LEU A CG  1 
ATOM 2609 C CD1 . LEU A 1 383 ? 223.144 229.571 171.089 1.00 119.82 ? 423 LEU A CD1 1 
ATOM 2610 C CD2 . LEU A 1 383 ? 223.103 227.374 169.905 1.00 121.04 ? 423 LEU A CD2 1 
ATOM 2611 N N   . SER A 1 384 ? 228.017 226.699 171.662 1.00 127.28 ? 424 SER A N   1 
ATOM 2612 C CA  . SER A 1 384 ? 229.339 226.745 172.266 1.00 126.63 ? 424 SER A CA  1 
ATOM 2613 C C   . SER A 1 384 ? 229.640 228.151 172.782 1.00 126.66 ? 424 SER A C   1 
ATOM 2614 O O   . SER A 1 384 ? 228.868 229.096 172.595 1.00 126.16 ? 424 SER A O   1 
ATOM 2615 C CB  . SER A 1 384 ? 230.397 226.297 171.263 1.00 130.07 ? 424 SER A CB  1 
ATOM 2616 O OG  . SER A 1 384 ? 231.678 226.776 171.632 1.00 130.68 ? 424 SER A OG  1 
ATOM 2617 N N   . ARG A 1 385 ? 230.791 228.282 173.446 1.00 128.08 ? 425 ARG A N   1 
ATOM 2618 C CA  . ARG A 1 385 ? 231.171 229.562 174.036 1.00 125.29 ? 425 ARG A CA  1 
ATOM 2619 C C   . ARG A 1 385 ? 231.399 230.624 172.968 1.00 128.46 ? 425 ARG A C   1 
ATOM 2620 O O   . ARG A 1 385 ? 231.042 231.792 173.160 1.00 126.06 ? 425 ARG A O   1 
ATOM 2621 C CB  . ARG A 1 385 ? 232.422 229.390 174.897 1.00 111.07 ? 425 ARG A CB  1 
ATOM 2622 N N   . THR A 1 386 ? 232.006 230.242 171.843 1.00 129.57 ? 426 THR A N   1 
ATOM 2623 C CA  . THR A 1 386 ? 232.258 231.205 170.774 1.00 129.19 ? 426 THR A CA  1 
ATOM 2624 C C   . THR A 1 386 ? 230.954 231.743 170.197 1.00 128.29 ? 426 THR A C   1 
ATOM 2625 O O   . THR A 1 386 ? 230.834 232.944 169.927 1.00 128.43 ? 426 THR A O   1 
ATOM 2626 C CB  . THR A 1 386 ? 233.109 230.558 169.680 1.00 134.32 ? 426 THR A CB  1 
ATOM 2627 O OG1 . THR A 1 386 ? 234.457 230.416 170.146 1.00 133.19 ? 426 THR A OG1 1 
ATOM 2628 C CG2 . THR A 1 386 ? 233.105 231.407 168.418 1.00 136.23 ? 426 THR A CG2 1 
ATOM 2629 N N   . GLN A 1 387 ? 229.963 230.869 170.003 1.00 127.52 ? 427 GLN A N   1 
ATOM 2630 C CA  . GLN A 1 387 ? 228.675 231.316 169.483 1.00 125.02 ? 427 GLN A CA  1 
ATOM 2631 C C   . GLN A 1 387 ? 227.998 232.284 170.444 1.00 124.47 ? 427 GLN A C   1 
ATOM 2632 O O   . GLN A 1 387 ? 227.419 233.291 170.019 1.00 124.16 ? 427 GLN A O   1 
ATOM 2633 C CB  . GLN A 1 387 ? 227.776 230.111 169.209 1.00 125.17 ? 427 GLN A CB  1 
ATOM 2634 C CG  . GLN A 1 387 ? 228.060 229.404 167.893 1.00 130.37 ? 427 GLN A CG  1 
ATOM 2635 C CD  . GLN A 1 387 ? 229.390 228.673 167.891 1.00 132.89 ? 427 GLN A CD  1 
ATOM 2636 O OE1 . GLN A 1 387 ? 230.003 228.471 168.938 1.00 131.81 ? 427 GLN A OE1 1 
ATOM 2637 N NE2 . GLN A 1 387 ? 229.842 228.272 166.709 1.00 132.22 ? 427 GLN A NE2 1 
ATOM 2638 N N   . LEU A 1 388 ? 228.058 231.996 171.745 1.00 124.16 ? 428 LEU A N   1 
ATOM 2639 C CA  . LEU A 1 388 ? 227.461 232.893 172.728 1.00 119.24 ? 428 LEU A CA  1 
ATOM 2640 C C   . LEU A 1 388 ? 228.200 234.224 172.783 1.00 119.44 ? 428 LEU A C   1 
ATOM 2641 O O   . LEU A 1 388 ? 227.579 235.278 172.957 1.00 118.70 ? 428 LEU A O   1 
ATOM 2642 C CB  . LEU A 1 388 ? 227.442 232.226 174.101 1.00 113.87 ? 428 LEU A CB  1 
ATOM 2643 C CG  . LEU A 1 388 ? 226.617 230.944 174.195 1.00 114.12 ? 428 LEU A CG  1 
ATOM 2644 C CD1 . LEU A 1 388 ? 227.133 230.056 175.311 1.00 115.06 ? 428 LEU A CD1 1 
ATOM 2645 C CD2 . LEU A 1 388 ? 225.152 231.275 174.405 1.00 112.01 ? 428 LEU A CD2 1 
ATOM 2646 N N   . LEU A 1 389 ? 229.527 234.195 172.649 1.00 122.19 ? 429 LEU A N   1 
ATOM 2647 C CA  . LEU A 1 389 ? 230.290 235.437 172.601 1.00 122.61 ? 429 LEU A CA  1 
ATOM 2648 C C   . LEU A 1 389 ? 229.911 236.262 171.379 1.00 124.44 ? 429 LEU A C   1 
ATOM 2649 O O   . LEU A 1 389 ? 229.793 237.490 171.461 1.00 124.29 ? 429 LEU A O   1 
ATOM 2650 C CB  . LEU A 1 389 ? 231.787 235.134 172.604 1.00 123.61 ? 429 LEU A CB  1 
ATOM 2651 C CG  . LEU A 1 389 ? 232.510 235.367 173.931 1.00 124.14 ? 429 LEU A CG  1 
ATOM 2652 C CD1 . LEU A 1 389 ? 233.994 235.069 173.796 1.00 121.95 ? 429 LEU A CD1 1 
ATOM 2653 C CD2 . LEU A 1 389 ? 232.287 236.790 174.413 1.00 122.42 ? 429 LEU A CD2 1 
ATOM 2654 N N   . HIS A 1 390 ? 229.722 235.602 170.234 1.00 127.25 ? 430 HIS A N   1 
ATOM 2655 C CA  . HIS A 1 390 ? 229.229 236.300 169.051 1.00 125.66 ? 430 HIS A CA  1 
ATOM 2656 C C   . HIS A 1 390 ? 227.845 236.881 169.303 1.00 120.22 ? 430 HIS A C   1 
ATOM 2657 O O   . HIS A 1 390 ? 227.518 237.965 168.807 1.00 116.89 ? 430 HIS A O   1 
ATOM 2658 C CB  . HIS A 1 390 ? 229.205 235.354 167.852 1.00 129.26 ? 430 HIS A CB  1 
ATOM 2659 C CG  . HIS A 1 390 ? 230.488 235.322 167.084 1.00 133.08 ? 430 HIS A CG  1 
ATOM 2660 N ND1 . HIS A 1 390 ? 230.699 234.469 166.022 1.00 138.52 ? 430 HIS A ND1 1 
ATOM 2661 C CD2 . HIS A 1 390 ? 231.628 236.039 167.223 1.00 134.32 ? 430 HIS A CD2 1 
ATOM 2662 C CE1 . HIS A 1 390 ? 231.914 234.662 165.541 1.00 142.04 ? 430 HIS A CE1 1 
ATOM 2663 N NE2 . HIS A 1 390 ? 232.499 235.610 166.252 1.00 141.79 ? 430 HIS A NE2 1 
ATOM 2664 N N   . LEU A 1 391 ? 227.015 236.167 170.065 1.00 119.22 ? 431 LEU A N   1 
ATOM 2665 C CA  . LEU A 1 391 ? 225.741 236.732 170.491 1.00 119.66 ? 431 LEU A CA  1 
ATOM 2666 C C   . LEU A 1 391 ? 225.959 237.962 171.363 1.00 117.88 ? 431 LEU A C   1 
ATOM 2667 O O   . LEU A 1 391 ? 225.214 238.943 171.264 1.00 115.24 ? 431 LEU A O   1 
ATOM 2668 C CB  . LEU A 1 391 ? 224.920 235.679 171.235 1.00 118.13 ? 431 LEU A CB  1 
ATOM 2669 C CG  . LEU A 1 391 ? 223.965 234.847 170.379 1.00 112.34 ? 431 LEU A CG  1 
ATOM 2670 C CD1 . LEU A 1 391 ? 223.087 233.972 171.253 1.00 108.36 ? 431 LEU A CD1 1 
ATOM 2671 C CD2 . LEU A 1 391 ? 223.120 235.750 169.503 1.00 111.59 ? 431 LEU A CD2 1 
ATOM 2672 N N   . GLY A 1 392 ? 226.972 237.926 172.225 1.00 118.36 ? 432 GLY A N   1 
ATOM 2673 C CA  . GLY A 1 392 ? 227.357 239.102 172.978 1.00 118.69 ? 432 GLY A CA  1 
ATOM 2674 C C   . GLY A 1 392 ? 227.473 238.900 174.474 1.00 121.69 ? 432 GLY A C   1 
ATOM 2675 O O   . GLY A 1 392 ? 227.845 239.830 175.196 1.00 125.62 ? 432 GLY A O   1 
ATOM 2676 N N   . LEU A 1 393 ? 227.149 237.703 174.956 1.00 119.44 ? 433 LEU A N   1 
ATOM 2677 C CA  . LEU A 1 393 ? 227.168 237.451 176.391 1.00 116.85 ? 433 LEU A CA  1 
ATOM 2678 C C   . LEU A 1 393 ? 228.580 237.591 176.947 1.00 117.77 ? 433 LEU A C   1 
ATOM 2679 O O   . LEU A 1 393 ? 229.563 237.223 176.298 1.00 121.01 ? 433 LEU A O   1 
ATOM 2680 C CB  . LEU A 1 393 ? 226.621 236.056 176.691 1.00 112.68 ? 433 LEU A CB  1 
ATOM 2681 C CG  . LEU A 1 393 ? 225.249 235.733 176.100 1.00 111.28 ? 433 LEU A CG  1 
ATOM 2682 C CD1 . LEU A 1 393 ? 224.747 234.396 176.613 1.00 106.42 ? 433 LEU A CD1 1 
ATOM 2683 C CD2 . LEU A 1 393 ? 224.258 236.836 176.420 1.00 110.73 ? 433 LEU A CD2 1 
ATOM 2684 N N   . THR A 1 394 ? 228.675 238.134 178.157 1.00 114.67 ? 434 THR A N   1 
ATOM 2685 C CA  . THR A 1 394 ? 229.965 238.321 178.799 1.00 114.63 ? 434 THR A CA  1 
ATOM 2686 C C   . THR A 1 394 ? 230.525 236.980 179.269 1.00 114.17 ? 434 THR A C   1 
ATOM 2687 O O   . THR A 1 394 ? 229.850 235.949 179.247 1.00 115.04 ? 434 THR A O   1 
ATOM 2688 C CB  . THR A 1 394 ? 229.845 239.282 179.980 1.00 113.61 ? 434 THR A CB  1 
ATOM 2689 O OG1 . THR A 1 394 ? 229.518 238.545 181.164 1.00 111.19 ? 434 THR A OG1 1 
ATOM 2690 C CG2 . THR A 1 394 ? 228.757 240.309 179.715 1.00 113.23 ? 434 THR A CG2 1 
ATOM 2691 N N   . GLN A 1 395 ? 231.787 237.007 179.702 1.00 110.00 ? 435 GLN A N   1 
ATOM 2692 C CA  . GLN A 1 395 ? 232.439 235.781 180.152 1.00 107.62 ? 435 GLN A CA  1 
ATOM 2693 C C   . GLN A 1 395 ? 231.739 235.195 181.372 1.00 108.14 ? 435 GLN A C   1 
ATOM 2694 O O   . GLN A 1 395 ? 231.553 233.976 181.464 1.00 109.26 ? 435 GLN A O   1 
ATOM 2695 C CB  . GLN A 1 395 ? 233.912 236.052 180.457 1.00 106.49 ? 435 GLN A CB  1 
ATOM 2696 N N   . GLY A 1 396 ? 231.341 236.048 182.319 1.00 105.13 ? 436 GLY A N   1 
ATOM 2697 C CA  . GLY A 1 396 ? 230.674 235.552 183.512 1.00 104.00 ? 436 GLY A CA  1 
ATOM 2698 C C   . GLY A 1 396 ? 229.332 234.912 183.214 1.00 107.27 ? 436 GLY A C   1 
ATOM 2699 O O   . GLY A 1 396 ? 228.997 233.862 183.768 1.00 108.84 ? 436 GLY A O   1 
ATOM 2700 N N   . LEU A 1 397 ? 228.543 235.536 182.337 1.00 106.87 ? 437 LEU A N   1 
ATOM 2701 C CA  . LEU A 1 397 ? 227.241 234.976 181.992 1.00 101.50 ? 437 LEU A CA  1 
ATOM 2702 C C   . LEU A 1 397 ? 227.385 233.644 181.268 1.00 102.02 ? 437 LEU A C   1 
ATOM 2703 O O   . LEU A 1 397 ? 226.618 232.708 181.522 1.00 105.29 ? 437 LEU A O   1 
ATOM 2704 C CB  . LEU A 1 397 ? 226.448 235.969 181.144 1.00 102.49 ? 437 LEU A CB  1 
ATOM 2705 C CG  . LEU A 1 397 ? 225.549 236.944 181.908 1.00 101.48 ? 437 LEU A CG  1 
ATOM 2706 C CD1 . LEU A 1 397 ? 224.519 236.187 182.726 1.00 98.02  ? 437 LEU A CD1 1 
ATOM 2707 C CD2 . LEU A 1 397 ? 226.360 237.878 182.793 1.00 104.03 ? 437 LEU A CD2 1 
ATOM 2708 N N   . ILE A 1 398 ? 228.358 233.539 180.360 1.00 101.93 ? 438 ILE A N   1 
ATOM 2709 C CA  . ILE A 1 398 ? 228.606 232.270 179.681 1.00 101.33 ? 438 ILE A CA  1 
ATOM 2710 C C   . ILE A 1 398 ? 229.037 231.208 180.681 1.00 105.46 ? 438 ILE A C   1 
ATOM 2711 O O   . ILE A 1 398 ? 228.589 230.057 180.619 1.00 108.03 ? 438 ILE A O   1 
ATOM 2712 C CB  . ILE A 1 398 ? 229.651 232.451 178.566 1.00 101.62 ? 438 ILE A CB  1 
ATOM 2713 C CG1 . ILE A 1 398 ? 229.148 233.438 177.515 1.00 107.39 ? 438 ILE A CG1 1 
ATOM 2714 C CG2 . ILE A 1 398 ? 229.974 231.115 177.921 1.00 102.87 ? 438 ILE A CG2 1 
ATOM 2715 C CD1 . ILE A 1 398 ? 230.026 233.511 176.286 1.00 117.50 ? 438 ILE A CD1 1 
ATOM 2716 N N   . GLU A 1 399 ? 229.916 231.574 181.618 1.00 107.11 ? 439 GLU A N   1 
ATOM 2717 C CA  . GLU A 1 399 ? 230.356 230.619 182.629 1.00 104.36 ? 439 GLU A CA  1 
ATOM 2718 C C   . GLU A 1 399 ? 229.186 230.143 183.480 1.00 104.35 ? 439 GLU A C   1 
ATOM 2719 O O   . GLU A 1 399 ? 229.116 228.965 183.850 1.00 106.74 ? 439 GLU A O   1 
ATOM 2720 C CB  . GLU A 1 399 ? 231.440 231.244 183.506 1.00 100.70 ? 439 GLU A CB  1 
ATOM 2721 N N   . ARG A 1 400 ? 228.265 231.048 183.813 1.00 103.29 ? 440 ARG A N   1 
ATOM 2722 C CA  . ARG A 1 400 ? 227.074 230.648 184.555 1.00 101.83 ? 440 ARG A CA  1 
ATOM 2723 C C   . ARG A 1 400 ? 226.192 229.718 183.731 1.00 100.92 ? 440 ARG A C   1 
ATOM 2724 O O   . ARG A 1 400 ? 225.679 228.719 184.250 1.00 102.10 ? 440 ARG A O   1 
ATOM 2725 C CB  . ARG A 1 400 ? 226.287 231.883 184.989 1.00 99.88  ? 440 ARG A CB  1 
ATOM 2726 C CG  . ARG A 1 400 ? 226.938 232.663 186.114 1.00 101.28 ? 440 ARG A CG  1 
ATOM 2727 C CD  . ARG A 1 400 ? 226.141 233.908 186.452 1.00 102.92 ? 440 ARG A CD  1 
ATOM 2728 N NE  . ARG A 1 400 ? 224.708 233.647 186.492 1.00 100.66 ? 440 ARG A NE  1 
ATOM 2729 C CZ  . ARG A 1 400 ? 223.801 234.524 186.897 1.00 100.93 ? 440 ARG A CZ  1 
ATOM 2730 N NH1 . ARG A 1 400 ? 224.144 235.735 187.304 1.00 100.44 ? 440 ARG A NH1 1 
ATOM 2731 N NH2 . ARG A 1 400 ? 222.517 234.178 186.897 1.00 99.80  ? 440 ARG A NH2 1 
ATOM 2732 N N   . LEU A 1 401 ? 225.997 230.030 182.449 1.00 100.60 ? 441 LEU A N   1 
ATOM 2733 C CA  . LEU A 1 401 ? 225.111 229.223 181.615 1.00 98.46  ? 441 LEU A CA  1 
ATOM 2734 C C   . LEU A 1 401 ? 225.742 227.880 181.271 1.00 100.82 ? 441 LEU A C   1 
ATOM 2735 O O   . LEU A 1 401 ? 225.095 226.832 181.384 1.00 102.04 ? 441 LEU A O   1 
ATOM 2736 C CB  . LEU A 1 401 ? 224.754 229.988 180.343 1.00 98.88  ? 441 LEU A CB  1 
ATOM 2737 C CG  . LEU A 1 401 ? 224.298 229.154 179.148 1.00 99.84  ? 441 LEU A CG  1 
ATOM 2738 C CD1 . LEU A 1 401 ? 222.884 228.651 179.364 1.00 100.09 ? 441 LEU A CD1 1 
ATOM 2739 C CD2 . LEU A 1 401 ? 224.387 229.969 177.874 1.00 105.11 ? 441 LEU A CD2 1 
ATOM 2740 N N   . LYS A 1 402 ? 227.002 227.888 180.854 1.00 104.61 ? 442 LYS A N   1 
ATOM 2741 C CA  . LYS A 1 402 ? 227.667 226.663 180.430 1.00 107.76 ? 442 LYS A CA  1 
ATOM 2742 C C   . LYS A 1 402 ? 228.239 225.904 181.618 1.00 112.68 ? 442 LYS A C   1 
ATOM 2743 O O   . LYS A 1 402 ? 228.332 224.678 181.598 1.00 117.54 ? 442 LYS A O   1 
ATOM 2744 C CB  . LYS A 1 402 ? 228.776 226.974 179.425 1.00 109.60 ? 442 LYS A CB  1 
ATOM 2745 C CG  . LYS A 1 402 ? 228.308 227.018 177.981 1.00 108.34 ? 442 LYS A CG  1 
ATOM 2746 C CD  . LYS A 1 402 ? 227.512 225.776 177.627 1.00 109.97 ? 442 LYS A CD  1 
ATOM 2747 C CE  . LYS A 1 402 ? 227.911 225.238 176.266 1.00 116.34 ? 442 LYS A CE  1 
ATOM 2748 N NZ  . LYS A 1 402 ? 227.007 224.147 175.813 1.00 121.26 ? 442 LYS A NZ  1 
ATOM 2749 O OXT . LYS A 1 402 ? 228.620 226.497 182.625 1.00 112.46 ? 442 LYS A OXT 1 
ATOM 2750 N N   . ASP B 2 2   ? 196.857 253.998 193.761 1.00 110.43 ? 2   ASP B N   1 
ATOM 2751 C CA  . ASP B 2 2   ? 198.132 254.505 193.272 1.00 111.03 ? 2   ASP B CA  1 
ATOM 2752 C C   . ASP B 2 2   ? 198.437 253.976 191.876 1.00 110.49 ? 2   ASP B C   1 
ATOM 2753 O O   . ASP B 2 2   ? 198.701 252.788 191.697 1.00 110.34 ? 2   ASP B O   1 
ATOM 2754 C CB  . ASP B 2 2   ? 199.261 254.130 194.232 1.00 112.83 ? 2   ASP B CB  1 
ATOM 2755 C CG  . ASP B 2 2   ? 200.154 255.305 194.565 1.00 118.26 ? 2   ASP B CG  1 
ATOM 2756 O OD1 . ASP B 2 2   ? 199.867 256.423 194.090 1.00 119.65 ? 2   ASP B OD1 1 
ATOM 2757 O OD2 . ASP B 2 2   ? 201.144 255.112 195.300 1.00 120.49 ? 2   ASP B OD2 1 
ATOM 2758 N N   . VAL B 2 3   ? 198.401 254.867 190.892 1.00 106.63 ? 3   VAL B N   1 
ATOM 2759 C CA  . VAL B 2 3   ? 198.681 254.519 189.509 1.00 97.75  ? 3   VAL B CA  1 
ATOM 2760 C C   . VAL B 2 3   ? 200.002 255.154 189.100 1.00 96.46  ? 3   VAL B C   1 
ATOM 2761 O O   . VAL B 2 3   ? 200.489 256.108 189.715 1.00 99.22  ? 3   VAL B O   1 
ATOM 2762 C CB  . VAL B 2 3   ? 197.550 254.961 188.561 1.00 96.58  ? 3   VAL B CB  1 
ATOM 2763 C CG1 . VAL B 2 3   ? 196.333 254.078 188.744 1.00 104.28 ? 3   VAL B CG1 1 
ATOM 2764 C CG2 . VAL B 2 3   ? 197.199 256.417 188.805 1.00 101.57 ? 3   VAL B CG2 1 
ATOM 2765 N N   . PHE B 2 4   ? 200.583 254.610 188.038 1.00 94.05  ? 4   PHE B N   1 
ATOM 2766 C CA  . PHE B 2 4   ? 201.834 255.096 187.480 1.00 90.98  ? 4   PHE B CA  1 
ATOM 2767 C C   . PHE B 2 4   ? 201.603 255.470 186.025 1.00 84.58  ? 4   PHE B C   1 
ATOM 2768 O O   . PHE B 2 4   ? 200.750 254.881 185.355 1.00 89.40  ? 4   PHE B O   1 
ATOM 2769 C CB  . PHE B 2 4   ? 202.934 254.043 187.614 1.00 89.20  ? 4   PHE B CB  1 
ATOM 2770 C CG  . PHE B 2 4   ? 203.192 253.626 189.033 1.00 89.83  ? 4   PHE B CG  1 
ATOM 2771 C CD1 . PHE B 2 4   ? 202.419 252.649 189.633 1.00 89.46  ? 4   PHE B CD1 1 
ATOM 2772 C CD2 . PHE B 2 4   ? 204.196 254.223 189.772 1.00 94.34  ? 4   PHE B CD2 1 
ATOM 2773 C CE1 . PHE B 2 4   ? 202.648 252.271 190.940 1.00 92.58  ? 4   PHE B CE1 1 
ATOM 2774 C CE2 . PHE B 2 4   ? 204.430 253.847 191.080 1.00 95.75  ? 4   PHE B CE2 1 
ATOM 2775 C CZ  . PHE B 2 4   ? 203.655 252.869 191.663 1.00 94.62  ? 4   PHE B CZ  1 
ATOM 2776 N N   . LEU B 2 5   ? 202.333 256.475 185.546 1.00 72.17  ? 5   LEU B N   1 
ATOM 2777 C CA  . LEU B 2 5   ? 202.046 257.071 184.252 1.00 68.88  ? 5   LEU B CA  1 
ATOM 2778 C C   . LEU B 2 5   ? 203.331 257.392 183.507 1.00 74.16  ? 5   LEU B C   1 
ATOM 2779 O O   . LEU B 2 5   ? 204.361 257.716 184.110 1.00 82.77  ? 5   LEU B O   1 
ATOM 2780 C CB  . LEU B 2 5   ? 201.217 258.351 184.403 1.00 65.36  ? 5   LEU B CB  1 
ATOM 2781 C CG  . LEU B 2 5   ? 199.858 258.203 185.083 1.00 73.05  ? 5   LEU B CG  1 
ATOM 2782 C CD1 . LEU B 2 5   ? 199.310 259.561 185.484 1.00 74.37  ? 5   LEU B CD1 1 
ATOM 2783 C CD2 . LEU B 2 5   ? 198.891 257.471 184.169 1.00 70.53  ? 5   LEU B CD2 1 
ATOM 2784 N N   . MET B 2 6   ? 203.245 257.309 182.180 1.00 66.59  ? 6   MET B N   1 
ATOM 2785 C CA  . MET B 2 6   ? 204.276 257.787 181.263 1.00 59.04  ? 6   MET B CA  1 
ATOM 2786 C C   . MET B 2 6   ? 203.630 258.831 180.357 1.00 58.48  ? 6   MET B C   1 
ATOM 2787 O O   . MET B 2 6   ? 202.925 258.487 179.404 1.00 67.19  ? 6   MET B O   1 
ATOM 2788 C CB  . MET B 2 6   ? 204.878 256.649 180.445 1.00 60.72  ? 6   MET B CB  1 
ATOM 2789 C CG  . MET B 2 6   ? 205.702 255.664 181.248 1.00 67.58  ? 6   MET B CG  1 
ATOM 2790 S SD  . MET B 2 6   ? 206.277 254.266 180.264 1.00 82.94  ? 6   MET B SD  1 
ATOM 2791 C CE  . MET B 2 6   ? 205.052 254.226 178.963 1.00 76.19  ? 6   MET B CE  1 
ATOM 2792 N N   . ILE B 2 7   ? 203.866 260.103 180.662 1.00 54.51  ? 7   ILE B N   1 
ATOM 2793 C CA  . ILE B 2 7   ? 203.413 261.188 179.800 1.00 57.17  ? 7   ILE B CA  1 
ATOM 2794 C C   . ILE B 2 7   ? 204.259 261.177 178.534 1.00 61.37  ? 7   ILE B C   1 
ATOM 2795 O O   . ILE B 2 7   ? 205.492 261.195 178.600 1.00 65.33  ? 7   ILE B O   1 
ATOM 2796 C CB  . ILE B 2 7   ? 203.509 262.539 180.522 1.00 57.90  ? 7   ILE B CB  1 
ATOM 2797 C CG1 . ILE B 2 7   ? 202.301 262.768 181.434 1.00 59.54  ? 7   ILE B CG1 1 
ATOM 2798 C CG2 . ILE B 2 7   ? 203.628 263.670 179.518 1.00 65.78  ? 7   ILE B CG2 1 
ATOM 2799 C CD1 . ILE B 2 7   ? 202.335 261.994 182.734 1.00 64.90  ? 7   ILE B CD1 1 
ATOM 2800 N N   . ARG B 2 8   ? 203.605 261.144 177.376 1.00 59.94  ? 8   ARG B N   1 
ATOM 2801 C CA  . ARG B 2 8   ? 204.287 261.040 176.093 1.00 58.27  ? 8   ARG B CA  1 
ATOM 2802 C C   . ARG B 2 8   ? 204.008 262.274 175.251 1.00 67.61  ? 8   ARG B C   1 
ATOM 2803 O O   . ARG B 2 8   ? 202.852 262.678 175.101 1.00 78.35  ? 8   ARG B O   1 
ATOM 2804 C CB  . ARG B 2 8   ? 203.844 259.787 175.336 1.00 59.76  ? 8   ARG B CB  1 
ATOM 2805 C CG  . ARG B 2 8   ? 203.787 258.537 176.185 1.00 61.81  ? 8   ARG B CG  1 
ATOM 2806 C CD  . ARG B 2 8   ? 205.164 257.932 176.344 1.00 66.31  ? 8   ARG B CD  1 
ATOM 2807 N NE  . ARG B 2 8   ? 205.918 257.963 175.098 1.00 67.78  ? 8   ARG B NE  1 
ATOM 2808 C CZ  . ARG B 2 8   ? 205.858 257.027 174.161 1.00 70.88  ? 8   ARG B CZ  1 
ATOM 2809 N NH1 . ARG B 2 8   ? 205.074 255.970 174.290 1.00 75.31  ? 8   ARG B NH1 1 
ATOM 2810 N NH2 . ARG B 2 8   ? 206.604 257.155 173.069 1.00 69.76  ? 8   ARG B NH2 1 
ATOM 2811 N N   . ARG B 2 9   ? 205.066 262.865 174.699 1.00 67.86  ? 9   ARG B N   1 
ATOM 2812 C CA  . ARG B 2 9   ? 204.917 263.961 173.745 1.00 71.19  ? 9   ARG B CA  1 
ATOM 2813 C C   . ARG B 2 9   ? 206.155 264.003 172.868 1.00 82.80  ? 9   ARG B C   1 
ATOM 2814 O O   . ARG B 2 9   ? 207.252 264.275 173.367 1.00 87.58  ? 9   ARG B O   1 
ATOM 2815 C CB  . ARG B 2 9   ? 204.718 265.296 174.452 1.00 74.22  ? 9   ARG B CB  1 
ATOM 2816 C CG  . ARG B 2 9   ? 204.524 266.452 173.487 1.00 79.41  ? 9   ARG B CG  1 
ATOM 2817 C CD  . ARG B 2 9   ? 205.058 267.756 174.045 1.00 81.09  ? 9   ARG B CD  1 
ATOM 2818 N NE  . ARG B 2 9   ? 205.157 268.779 173.011 1.00 82.87  ? 9   ARG B NE  1 
ATOM 2819 C CZ  . ARG B 2 9   ? 206.194 268.922 172.198 1.00 89.55  ? 9   ARG B CZ  1 
ATOM 2820 N NH1 . ARG B 2 9   ? 207.251 268.132 172.281 1.00 89.18  ? 9   ARG B NH1 1 
ATOM 2821 N NH2 . ARG B 2 9   ? 206.171 269.883 171.279 1.00 93.37  ? 9   ARG B NH2 1 
ATOM 2822 N N   . HIS B 2 10  ? 205.979 263.748 171.573 1.00 86.79  ? 10  HIS B N   1 
ATOM 2823 C CA  . HIS B 2 10  ? 207.075 263.707 170.595 1.00 85.97  ? 10  HIS B CA  1 
ATOM 2824 C C   . HIS B 2 10  ? 208.076 262.664 171.084 1.00 83.98  ? 10  HIS B C   1 
ATOM 2825 O O   . HIS B 2 10  ? 207.668 261.535 171.399 1.00 82.04  ? 10  HIS B O   1 
ATOM 2826 C CB  . HIS B 2 10  ? 207.627 265.111 170.385 1.00 87.16  ? 10  HIS B CB  1 
ATOM 2827 C CG  . HIS B 2 10  ? 206.911 265.887 169.325 1.00 94.36  ? 10  HIS B CG  1 
ATOM 2828 N ND1 . HIS B 2 10  ? 206.469 267.178 169.517 1.00 99.77  ? 10  HIS B ND1 1 
ATOM 2829 C CD2 . HIS B 2 10  ? 206.557 265.552 168.062 1.00 95.54  ? 10  HIS B CD2 1 
ATOM 2830 C CE1 . HIS B 2 10  ? 205.875 267.605 168.418 1.00 101.06 ? 10  HIS B CE1 1 
ATOM 2831 N NE2 . HIS B 2 10  ? 205.915 266.638 167.519 1.00 99.29  ? 10  HIS B NE2 1 
ATOM 2832 N N   . LYS B 2 11  ? 209.366 262.978 171.168 1.00 80.04  ? 11  LYS B N   1 
ATOM 2833 C CA  . LYS B 2 11  ? 210.364 262.035 171.645 1.00 82.72  ? 11  LYS B CA  1 
ATOM 2834 C C   . LYS B 2 11  ? 210.579 262.126 173.149 1.00 80.71  ? 11  LYS B C   1 
ATOM 2835 O O   . LYS B 2 11  ? 211.604 261.651 173.648 1.00 80.79  ? 11  LYS B O   1 
ATOM 2836 C CB  . LYS B 2 11  ? 211.686 262.257 170.910 1.00 84.15  ? 11  LYS B CB  1 
ATOM 2837 C CG  . LYS B 2 11  ? 211.651 261.872 169.443 1.00 80.41  ? 11  LYS B CG  1 
ATOM 2838 C CD  . LYS B 2 11  ? 213.033 261.498 168.939 1.00 74.25  ? 11  LYS B CD  1 
ATOM 2839 C CE  . LYS B 2 11  ? 212.964 260.887 167.552 1.00 81.81  ? 11  LYS B CE  1 
ATOM 2840 N NZ  . LYS B 2 11  ? 211.768 260.019 167.390 1.00 87.14  ? 11  LYS B NZ  1 
ATOM 2841 N N   . THR B 2 12  ? 209.637 262.718 173.878 1.00 78.31  ? 12  THR B N   1 
ATOM 2842 C CA  . THR B 2 12  ? 209.775 262.961 175.307 1.00 72.05  ? 12  THR B CA  1 
ATOM 2843 C C   . THR B 2 12  ? 208.818 262.066 176.077 1.00 71.57  ? 12  THR B C   1 
ATOM 2844 O O   . THR B 2 12  ? 207.637 261.966 175.729 1.00 79.28  ? 12  THR B O   1 
ATOM 2845 C CB  . THR B 2 12  ? 209.501 264.428 175.645 1.00 76.32  ? 12  THR B CB  1 
ATOM 2846 O OG1 . THR B 2 12  ? 210.030 265.266 174.611 1.00 92.30  ? 12  THR B OG1 1 
ATOM 2847 C CG2 . THR B 2 12  ? 210.148 264.797 176.968 1.00 75.01  ? 12  THR B CG2 1 
ATOM 2848 N N   . THR B 2 13  ? 209.335 261.413 177.116 1.00 65.91  ? 13  THR B N   1 
ATOM 2849 C CA  . THR B 2 13  ? 208.541 260.591 178.016 1.00 60.11  ? 13  THR B CA  1 
ATOM 2850 C C   . THR B 2 13  ? 208.869 260.972 179.450 1.00 59.82  ? 13  THR B C   1 
ATOM 2851 O O   . THR B 2 13  ? 210.040 261.126 179.807 1.00 67.61  ? 13  THR B O   1 
ATOM 2852 C CB  . THR B 2 13  ? 208.817 259.101 177.821 1.00 62.52  ? 13  THR B CB  1 
ATOM 2853 O OG1 . THR B 2 13  ? 210.114 258.795 178.341 1.00 69.85  ? 13  THR B OG1 1 
ATOM 2854 C CG2 . THR B 2 13  ? 208.783 258.736 176.350 1.00 69.65  ? 13  THR B CG2 1 
ATOM 2855 N N   . ILE B 2 14  ? 207.834 261.118 180.269 1.00 56.67  ? 14  ILE B N   1 
ATOM 2856 C CA  . ILE B 2 14  ? 207.982 261.474 181.676 1.00 57.44  ? 14  ILE B CA  1 
ATOM 2857 C C   . ILE B 2 14  ? 207.376 260.360 182.512 1.00 58.72  ? 14  ILE B C   1 
ATOM 2858 O O   . ILE B 2 14  ? 206.202 260.016 182.334 1.00 66.57  ? 14  ILE B O   1 
ATOM 2859 C CB  . ILE B 2 14  ? 207.316 262.818 182.001 1.00 57.53  ? 14  ILE B CB  1 
ATOM 2860 C CG1 . ILE B 2 14  ? 207.868 263.923 181.103 1.00 64.39  ? 14  ILE B CG1 1 
ATOM 2861 C CG2 . ILE B 2 14  ? 207.519 263.164 183.463 1.00 61.95  ? 14  ILE B CG2 1 
ATOM 2862 C CD1 . ILE B 2 14  ? 207.478 265.313 181.544 1.00 70.73  ? 14  ILE B CD1 1 
ATOM 2863 N N   . PHE B 2 15  ? 208.165 259.808 183.427 1.00 54.91  ? 15  PHE B N   1 
ATOM 2864 C CA  . PHE B 2 15  ? 207.689 258.781 184.343 1.00 56.14  ? 15  PHE B CA  1 
ATOM 2865 C C   . PHE B 2 15  ? 207.256 259.438 185.645 1.00 65.18  ? 15  PHE B C   1 
ATOM 2866 O O   . PHE B 2 15  ? 208.010 260.222 186.229 1.00 77.11  ? 15  PHE B O   1 
ATOM 2867 C CB  . PHE B 2 15  ? 208.782 257.748 184.615 1.00 57.70  ? 15  PHE B CB  1 
ATOM 2868 C CG  . PHE B 2 15  ? 209.076 256.852 183.450 1.00 60.61  ? 15  PHE B CG  1 
ATOM 2869 C CD1 . PHE B 2 15  ? 209.796 257.317 182.366 1.00 62.27  ? 15  PHE B CD1 1 
ATOM 2870 C CD2 . PHE B 2 15  ? 208.638 255.542 183.442 1.00 64.81  ? 15  PHE B CD2 1 
ATOM 2871 C CE1 . PHE B 2 15  ? 210.068 256.493 181.293 1.00 62.65  ? 15  PHE B CE1 1 
ATOM 2872 C CE2 . PHE B 2 15  ? 208.909 254.714 182.373 1.00 65.45  ? 15  PHE B CE2 1 
ATOM 2873 C CZ  . PHE B 2 15  ? 209.622 255.191 181.296 1.00 61.21  ? 15  PHE B CZ  1 
ATOM 2874 N N   . THR B 2 16  ? 206.046 259.123 186.100 1.00 69.98  ? 16  THR B N   1 
ATOM 2875 C CA  . THR B 2 16  ? 205.549 259.706 187.338 1.00 79.48  ? 16  THR B CA  1 
ATOM 2876 C C   . THR B 2 16  ? 204.515 258.773 187.953 1.00 86.45  ? 16  THR B C   1 
ATOM 2877 O O   . THR B 2 16  ? 204.158 257.741 187.381 1.00 86.92  ? 16  THR B O   1 
ATOM 2878 C CB  . THR B 2 16  ? 204.959 261.098 187.099 1.00 80.17  ? 16  THR B CB  1 
ATOM 2879 O OG1 . THR B 2 16  ? 204.678 261.721 188.357 1.00 89.56  ? 16  THR B OG1 1 
ATOM 2880 C CG2 . THR B 2 16  ? 203.674 260.999 186.295 1.00 76.65  ? 16  THR B CG2 1 
ATOM 2881 N N   . ASP B 2 17  ? 204.033 259.149 189.134 1.00 90.38  ? 17  ASP B N   1 
ATOM 2882 C CA  . ASP B 2 17  ? 202.982 258.414 189.820 1.00 91.86  ? 17  ASP B CA  1 
ATOM 2883 C C   . ASP B 2 17  ? 201.940 259.386 190.358 1.00 97.08  ? 17  ASP B C   1 
ATOM 2884 O O   . ASP B 2 17  ? 202.197 260.581 190.519 1.00 97.16  ? 17  ASP B O   1 
ATOM 2885 C CB  . ASP B 2 17  ? 203.567 257.493 190.920 1.00 98.74  ? 17  ASP B CB  1 
ATOM 2886 C CG  . ASP B 2 17  ? 203.672 258.153 192.299 1.00 112.27 ? 17  ASP B CG  1 
ATOM 2887 O OD1 . ASP B 2 17  ? 203.663 259.394 192.427 1.00 117.44 ? 17  ASP B OD1 1 
ATOM 2888 O OD2 . ASP B 2 17  ? 203.766 257.395 193.287 1.00 116.65 ? 17  ASP B OD2 1 
ATOM 2889 N N   . ALA B 2 18  ? 200.746 258.860 190.612 1.00 102.76 ? 18  ALA B N   1 
ATOM 2890 C CA  . ALA B 2 18  ? 199.637 259.681 191.076 1.00 108.07 ? 18  ALA B CA  1 
ATOM 2891 C C   . ALA B 2 18  ? 198.663 258.795 191.836 1.00 114.20 ? 18  ALA B C   1 
ATOM 2892 O O   . ALA B 2 18  ? 198.741 257.568 191.788 1.00 112.35 ? 18  ALA B O   1 
ATOM 2893 C CB  . ALA B 2 18  ? 198.942 260.392 189.911 1.00 107.19 ? 18  ALA B CB  1 
ATOM 2894 N N   . LYS B 2 19  ? 197.756 259.437 192.560 1.00 119.48 ? 19  LYS B N   1 
ATOM 2895 C CA  . LYS B 2 19  ? 196.701 258.724 193.258 1.00 113.77 ? 19  LYS B CA  1 
ATOM 2896 C C   . LYS B 2 19  ? 195.451 258.655 192.389 1.00 112.43 ? 19  LYS B C   1 
ATOM 2897 O O   . LYS B 2 19  ? 195.244 259.474 191.491 1.00 115.87 ? 19  LYS B O   1 
ATOM 2898 C CB  . LYS B 2 19  ? 196.379 259.400 194.591 1.00 111.28 ? 19  LYS B CB  1 
ATOM 2899 N N   . GLU B 2 20  ? 194.617 257.650 192.660 1.00 111.55 ? 20  GLU B N   1 
ATOM 2900 C CA  . GLU B 2 20  ? 193.342 257.554 191.959 1.00 117.22 ? 20  GLU B CA  1 
ATOM 2901 C C   . GLU B 2 20  ? 192.463 258.765 192.241 1.00 120.88 ? 20  GLU B C   1 
ATOM 2902 O O   . GLU B 2 20  ? 191.613 259.121 191.418 1.00 122.73 ? 20  GLU B O   1 
ATOM 2903 C CB  . GLU B 2 20  ? 192.617 256.268 192.353 1.00 119.54 ? 20  GLU B CB  1 
ATOM 2904 C CG  . GLU B 2 20  ? 193.389 255.000 192.042 1.00 113.79 ? 20  GLU B CG  1 
ATOM 2905 C CD  . GLU B 2 20  ? 192.731 254.173 190.958 1.00 117.23 ? 20  GLU B CD  1 
ATOM 2906 O OE1 . GLU B 2 20  ? 191.508 254.323 190.753 1.00 120.22 ? 20  GLU B OE1 1 
ATOM 2907 O OE2 . GLU B 2 20  ? 193.436 253.370 190.313 1.00 118.27 ? 20  GLU B OE2 1 
ATOM 2908 N N   . SER B 2 21  ? 192.653 259.405 193.392 1.00 121.50 ? 21  SER B N   1 
ATOM 2909 C CA  . SER B 2 21  ? 191.926 260.614 193.749 1.00 124.72 ? 21  SER B CA  1 
ATOM 2910 C C   . SER B 2 21  ? 192.568 261.877 193.190 1.00 126.53 ? 21  SER B C   1 
ATOM 2911 O O   . SER B 2 21  ? 192.003 262.963 193.350 1.00 130.46 ? 21  SER B O   1 
ATOM 2912 C CB  . SER B 2 21  ? 191.814 260.731 195.272 1.00 125.27 ? 21  SER B CB  1 
ATOM 2913 O OG  . SER B 2 21  ? 192.929 261.418 195.811 1.00 125.50 ? 21  SER B OG  1 
ATOM 2914 N N   . SER B 2 22  ? 193.728 261.764 192.549 1.00 125.04 ? 22  SER B N   1 
ATOM 2915 C CA  . SER B 2 22  ? 194.368 262.927 191.954 1.00 125.01 ? 22  SER B CA  1 
ATOM 2916 C C   . SER B 2 22  ? 193.591 263.398 190.730 1.00 121.98 ? 22  SER B C   1 
ATOM 2917 O O   . SER B 2 22  ? 192.973 262.606 190.013 1.00 122.73 ? 22  SER B O   1 
ATOM 2918 C CB  . SER B 2 22  ? 195.811 262.606 191.568 1.00 121.66 ? 22  SER B CB  1 
ATOM 2919 O OG  . SER B 2 22  ? 196.576 262.254 192.707 1.00 122.88 ? 22  SER B OG  1 
ATOM 2920 N N   . THR B 2 23  ? 193.626 264.704 190.496 1.00 117.76 ? 23  THR B N   1 
ATOM 2921 C CA  . THR B 2 23  ? 192.900 265.307 189.392 1.00 116.67 ? 23  THR B CA  1 
ATOM 2922 C C   . THR B 2 23  ? 193.804 265.483 188.176 1.00 114.07 ? 23  THR B C   1 
ATOM 2923 O O   . THR B 2 23  ? 195.025 265.333 188.244 1.00 113.91 ? 23  THR B O   1 
ATOM 2924 C CB  . THR B 2 23  ? 192.314 266.655 189.808 1.00 117.13 ? 23  THR B CB  1 
ATOM 2925 O OG1 . THR B 2 23  ? 191.857 267.356 188.645 1.00 115.82 ? 23  THR B OG1 1 
ATOM 2926 C CG2 . THR B 2 23  ? 193.365 267.493 190.518 1.00 111.98 ? 23  THR B CG2 1 
ATOM 2927 N N   . VAL B 2 24  ? 193.176 265.804 187.043 1.00 112.29 ? 24  VAL B N   1 
ATOM 2928 C CA  . VAL B 2 24  ? 193.932 266.113 185.836 1.00 105.32 ? 24  VAL B CA  1 
ATOM 2929 C C   . VAL B 2 24  ? 194.746 267.384 186.031 1.00 106.84 ? 24  VAL B C   1 
ATOM 2930 O O   . VAL B 2 24  ? 195.874 267.495 185.529 1.00 109.13 ? 24  VAL B O   1 
ATOM 2931 C CB  . VAL B 2 24  ? 192.976 266.221 184.633 1.00 104.03 ? 24  VAL B CB  1 
ATOM 2932 C CG1 . VAL B 2 24  ? 193.620 266.988 183.492 1.00 106.88 ? 24  VAL B CG1 1 
ATOM 2933 C CG2 . VAL B 2 24  ? 192.548 264.837 184.174 1.00 106.98 ? 24  VAL B CG2 1 
ATOM 2934 N N   . PHE B 2 25  ? 194.203 268.352 186.773 1.00 107.66 ? 25  PHE B N   1 
ATOM 2935 C CA  . PHE B 2 25  ? 194.928 269.592 187.023 1.00 108.54 ? 25  PHE B CA  1 
ATOM 2936 C C   . PHE B 2 25  ? 196.212 269.337 187.803 1.00 106.01 ? 25  PHE B C   1 
ATOM 2937 O O   . PHE B 2 25  ? 197.220 270.015 187.585 1.00 104.43 ? 25  PHE B O   1 
ATOM 2938 C CB  . PHE B 2 25  ? 194.035 270.582 187.769 1.00 116.55 ? 25  PHE B CB  1 
ATOM 2939 C CG  . PHE B 2 25  ? 194.593 271.973 187.828 1.00 119.36 ? 25  PHE B CG  1 
ATOM 2940 C CD1 . PHE B 2 25  ? 194.383 272.861 186.787 1.00 118.07 ? 25  PHE B CD1 1 
ATOM 2941 C CD2 . PHE B 2 25  ? 195.325 272.394 188.924 1.00 121.07 ? 25  PHE B CD2 1 
ATOM 2942 C CE1 . PHE B 2 25  ? 194.895 274.142 186.838 1.00 120.29 ? 25  PHE B CE1 1 
ATOM 2943 C CE2 . PHE B 2 25  ? 195.839 273.673 188.981 1.00 120.09 ? 25  PHE B CE2 1 
ATOM 2944 C CZ  . PHE B 2 25  ? 195.624 274.548 187.937 1.00 120.69 ? 25  PHE B CZ  1 
ATOM 2945 N N   . GLU B 2 26  ? 196.194 268.370 188.722 1.00 107.50 ? 26  GLU B N   1 
ATOM 2946 C CA  . GLU B 2 26  ? 197.417 268.016 189.437 1.00 108.48 ? 26  GLU B CA  1 
ATOM 2947 C C   . GLU B 2 26  ? 198.467 267.455 188.486 1.00 103.03 ? 26  GLU B C   1 
ATOM 2948 O O   . GLU B 2 26  ? 199.658 267.773 188.602 1.00 104.58 ? 26  GLU B O   1 
ATOM 2949 C CB  . GLU B 2 26  ? 197.105 267.012 190.546 1.00 108.33 ? 26  GLU B CB  1 
ATOM 2950 N N   . LEU B 2 27  ? 198.044 266.612 187.542 1.00 95.84  ? 27  LEU B N   1 
ATOM 2951 C CA  . LEU B 2 27  ? 198.968 266.107 186.534 1.00 86.85  ? 27  LEU B CA  1 
ATOM 2952 C C   . LEU B 2 27  ? 199.549 267.248 185.711 1.00 92.64  ? 27  LEU B C   1 
ATOM 2953 O O   . LEU B 2 27  ? 200.760 267.293 185.460 1.00 100.92 ? 27  LEU B O   1 
ATOM 2954 C CB  . LEU B 2 27  ? 198.251 265.106 185.631 1.00 85.30  ? 27  LEU B CB  1 
ATOM 2955 C CG  . LEU B 2 27  ? 198.780 263.675 185.592 1.00 84.22  ? 27  LEU B CG  1 
ATOM 2956 C CD1 . LEU B 2 27  ? 198.153 262.916 184.437 1.00 87.95  ? 27  LEU B CD1 1 
ATOM 2957 C CD2 . LEU B 2 27  ? 200.289 263.672 185.471 1.00 86.78  ? 27  LEU B CD2 1 
ATOM 2958 N N   . LYS B 2 28  ? 198.699 268.185 185.290 1.00 91.43  ? 28  LYS B N   1 
ATOM 2959 C CA  . LYS B 2 28  ? 199.185 269.331 184.532 1.00 94.70  ? 28  LYS B CA  1 
ATOM 2960 C C   . LYS B 2 28  ? 200.173 270.148 185.353 1.00 100.99 ? 28  LYS B C   1 
ATOM 2961 O O   . LYS B 2 28  ? 201.185 270.623 184.829 1.00 101.52 ? 28  LYS B O   1 
ATOM 2962 C CB  . LYS B 2 28  ? 198.011 270.198 184.081 1.00 103.71 ? 28  LYS B CB  1 
ATOM 2963 C CG  . LYS B 2 28  ? 197.087 269.526 183.080 1.00 103.96 ? 28  LYS B CG  1 
ATOM 2964 C CD  . LYS B 2 28  ? 196.117 270.523 182.468 1.00 105.36 ? 28  LYS B CD  1 
ATOM 2965 C CE  . LYS B 2 28  ? 195.403 269.935 181.264 1.00 97.03  ? 28  LYS B CE  1 
ATOM 2966 N NZ  . LYS B 2 28  ? 193.938 270.181 181.308 1.00 99.86  ? 28  LYS B NZ  1 
ATOM 2967 N N   . ARG B 2 29  ? 199.903 270.308 186.650 1.00 104.18 ? 29  ARG B N   1 
ATOM 2968 C CA  . ARG B 2 29  ? 200.800 271.070 187.512 1.00 104.88 ? 29  ARG B CA  1 
ATOM 2969 C C   . ARG B 2 29  ? 202.157 270.390 187.648 1.00 103.63 ? 29  ARG B C   1 
ATOM 2970 O O   . ARG B 2 29  ? 203.199 271.055 187.608 1.00 106.11 ? 29  ARG B O   1 
ATOM 2971 C CB  . ARG B 2 29  ? 200.159 271.270 188.884 1.00 105.49 ? 29  ARG B CB  1 
ATOM 2972 C CG  . ARG B 2 29  ? 201.096 271.843 189.931 1.00 109.13 ? 29  ARG B CG  1 
ATOM 2973 C CD  . ARG B 2 29  ? 201.543 273.247 189.563 1.00 113.45 ? 29  ARG B CD  1 
ATOM 2974 N NE  . ARG B 2 29  ? 200.441 274.064 189.069 1.00 115.42 ? 29  ARG B NE  1 
ATOM 2975 C CZ  . ARG B 2 29  ? 199.522 274.628 189.839 1.00 119.14 ? 29  ARG B CZ  1 
ATOM 2976 N NH1 . ARG B 2 29  ? 199.536 274.482 191.154 1.00 120.62 ? 29  ARG B NH1 1 
ATOM 2977 N NH2 . ARG B 2 29  ? 198.565 275.359 189.276 1.00 117.88 ? 29  ARG B NH2 1 
ATOM 2978 N N   . ILE B 2 30  ? 202.174 269.066 187.810 1.00 99.38  ? 30  ILE B N   1 
ATOM 2979 C CA  . ILE B 2 30  ? 203.461 268.396 187.979 1.00 97.19  ? 30  ILE B CA  1 
ATOM 2980 C C   . ILE B 2 30  ? 204.252 268.408 186.673 1.00 99.48  ? 30  ILE B C   1 
ATOM 2981 O O   . ILE B 2 30  ? 205.473 268.611 186.678 1.00 105.85 ? 30  ILE B O   1 
ATOM 2982 C CB  . ILE B 2 30  ? 203.288 266.973 188.547 1.00 92.80  ? 30  ILE B CB  1 
ATOM 2983 C CG1 . ILE B 2 30  ? 202.616 266.031 187.550 1.00 93.29  ? 30  ILE B CG1 1 
ATOM 2984 C CG2 . ILE B 2 30  ? 202.518 267.011 189.858 1.00 97.00  ? 30  ILE B CG2 1 
ATOM 2985 C CD1 . ILE B 2 30  ? 202.747 264.574 187.929 1.00 88.30  ? 30  ILE B CD1 1 
ATOM 2986 N N   . VAL B 2 31  ? 203.581 268.221 185.531 1.00 96.73  ? 31  VAL B N   1 
ATOM 2987 C CA  . VAL B 2 31  ? 204.322 268.320 184.273 1.00 96.94  ? 31  VAL B CA  1 
ATOM 2988 C C   . VAL B 2 31  ? 204.775 269.754 184.019 1.00 102.30 ? 31  VAL B C   1 
ATOM 2989 O O   . VAL B 2 31  ? 205.809 269.976 183.377 1.00 102.58 ? 31  VAL B O   1 
ATOM 2990 C CB  . VAL B 2 31  ? 203.516 267.749 183.090 1.00 92.56  ? 31  VAL B CB  1 
ATOM 2991 C CG1 . VAL B 2 31  ? 202.854 266.443 183.478 1.00 91.14  ? 31  VAL B CG1 1 
ATOM 2992 C CG2 . VAL B 2 31  ? 202.479 268.743 182.611 1.00 95.05  ? 31  VAL B CG2 1 
ATOM 2993 N N   . GLU B 2 32  ? 204.034 270.746 184.519 1.00 105.68 ? 32  GLU B N   1 
ATOM 2994 C CA  . GLU B 2 32  ? 204.526 272.119 184.485 1.00 108.01 ? 32  GLU B CA  1 
ATOM 2995 C C   . GLU B 2 32  ? 205.788 272.254 185.321 1.00 104.92 ? 32  GLU B C   1 
ATOM 2996 O O   . GLU B 2 32  ? 206.731 272.952 184.935 1.00 105.22 ? 32  GLU B O   1 
ATOM 2997 C CB  . GLU B 2 32  ? 203.432 273.076 184.969 1.00 109.63 ? 32  GLU B CB  1 
ATOM 2998 C CG  . GLU B 2 32  ? 203.860 274.533 185.189 1.00 111.99 ? 32  GLU B CG  1 
ATOM 2999 C CD  . GLU B 2 32  ? 204.473 274.799 186.557 1.00 112.49 ? 32  GLU B CD  1 
ATOM 3000 O OE1 . GLU B 2 32  ? 204.570 273.859 187.373 1.00 111.91 ? 32  GLU B OE1 1 
ATOM 3001 O OE2 . GLU B 2 32  ? 204.860 275.958 186.815 1.00 114.92 ? 32  GLU B OE2 1 
ATOM 3002 N N   . GLY B 2 33  ? 205.813 271.600 186.479 1.00 102.08 ? 33  GLY B N   1 
ATOM 3003 C CA  . GLY B 2 33  ? 207.014 271.612 187.296 1.00 105.46 ? 33  GLY B CA  1 
ATOM 3004 C C   . GLY B 2 33  ? 208.206 271.002 186.584 1.00 107.00 ? 33  GLY B C   1 
ATOM 3005 O O   . GLY B 2 33  ? 209.331 271.491 186.707 1.00 113.92 ? 33  GLY B O   1 
ATOM 3006 N N   . ILE B 2 34  ? 207.978 269.926 185.829 1.00 103.49 ? 34  ILE B N   1 
ATOM 3007 C CA  . ILE B 2 34  ? 209.091 269.266 185.145 1.00 100.67 ? 34  ILE B CA  1 
ATOM 3008 C C   . ILE B 2 34  ? 209.547 270.076 183.934 1.00 102.07 ? 34  ILE B C   1 
ATOM 3009 O O   . ILE B 2 34  ? 210.693 270.537 183.878 1.00 109.05 ? 34  ILE B O   1 
ATOM 3010 C CB  . ILE B 2 34  ? 208.733 267.822 184.751 1.00 99.49  ? 34  ILE B CB  1 
ATOM 3011 C CG1 . ILE B 2 34  ? 208.007 267.102 185.887 1.00 103.33 ? 34  ILE B CG1 1 
ATOM 3012 C CG2 . ILE B 2 34  ? 209.984 267.060 184.347 1.00 102.53 ? 34  ILE B CG2 1 
ATOM 3013 C CD1 . ILE B 2 34  ? 206.932 266.151 185.418 1.00 98.81  ? 34  ILE B CD1 1 
ATOM 3014 N N   . LEU B 2 35  ? 208.670 270.261 182.946 1.00 101.48 ? 35  LEU B N   1 
ATOM 3015 C CA  . LEU B 2 35  ? 209.092 270.821 181.666 1.00 103.44 ? 35  LEU B CA  1 
ATOM 3016 C C   . LEU B 2 35  ? 208.722 272.291 181.484 1.00 106.94 ? 35  LEU B C   1 
ATOM 3017 O O   . LEU B 2 35  ? 208.880 272.819 180.379 1.00 107.98 ? 35  LEU B O   1 
ATOM 3018 C CB  . LEU B 2 35  ? 208.535 269.989 180.506 1.00 98.60  ? 35  LEU B CB  1 
ATOM 3019 C CG  . LEU B 2 35  ? 207.091 269.485 180.506 1.00 97.38  ? 35  LEU B CG  1 
ATOM 3020 C CD1 . LEU B 2 35  ? 206.102 270.610 180.245 1.00 100.03 ? 35  LEU B CD1 1 
ATOM 3021 C CD2 . LEU B 2 35  ? 206.927 268.380 179.477 1.00 87.50  ? 35  LEU B CD2 1 
ATOM 3022 N N   . LYS B 2 36  ? 208.240 272.959 182.532 1.00 108.21 ? 36  LYS B N   1 
ATOM 3023 C CA  . LYS B 2 36  ? 208.038 274.411 182.532 1.00 106.17 ? 36  LYS B CA  1 
ATOM 3024 C C   . LYS B 2 36  ? 207.095 274.855 181.409 1.00 109.83 ? 36  LYS B C   1 
ATOM 3025 O O   . LYS B 2 36  ? 207.478 275.570 180.482 1.00 114.37 ? 36  LYS B O   1 
ATOM 3026 C CB  . LYS B 2 36  ? 209.381 275.143 182.445 1.00 95.64  ? 36  LYS B CB  1 
ATOM 3027 N N   . ARG B 2 37  ? 205.841 274.410 181.508 1.00 107.33 ? 37  ARG B N   1 
ATOM 3028 C CA  . ARG B 2 37  ? 204.793 274.836 180.588 1.00 107.50 ? 37  ARG B CA  1 
ATOM 3029 C C   . ARG B 2 37  ? 203.504 274.978 181.390 1.00 116.59 ? 37  ARG B C   1 
ATOM 3030 O O   . ARG B 2 37  ? 203.083 274.014 182.053 1.00 117.78 ? 37  ARG B O   1 
ATOM 3031 C CB  . ARG B 2 37  ? 204.602 273.849 179.433 1.00 100.79 ? 37  ARG B CB  1 
ATOM 3032 N N   . PRO B 2 38  ? 202.858 276.142 181.351 1.00 120.08 ? 38  PRO B N   1 
ATOM 3033 C CA  . PRO B 2 38  ? 201.679 276.351 182.186 1.00 118.04 ? 38  PRO B CA  1 
ATOM 3034 C C   . PRO B 2 38  ? 200.572 275.386 181.815 1.00 113.84 ? 38  PRO B C   1 
ATOM 3035 O O   . PRO B 2 38  ? 200.440 274.981 180.644 1.00 110.26 ? 38  PRO B O   1 
ATOM 3036 C CB  . PRO B 2 38  ? 201.286 277.804 181.885 1.00 115.96 ? 38  PRO B CB  1 
ATOM 3037 C CG  . PRO B 2 38  ? 202.538 278.440 181.386 1.00 119.11 ? 38  PRO B CG  1 
ATOM 3038 C CD  . PRO B 2 38  ? 203.253 277.363 180.631 1.00 119.83 ? 38  PRO B CD  1 
ATOM 3039 N N   . PRO B 2 39  ? 199.749 274.983 182.787 1.00 110.48 ? 39  PRO B N   1 
ATOM 3040 C CA  . PRO B 2 39  ? 198.697 273.994 182.501 1.00 109.12 ? 39  PRO B CA  1 
ATOM 3041 C C   . PRO B 2 39  ? 197.695 274.450 181.458 1.00 109.50 ? 39  PRO B C   1 
ATOM 3042 O O   . PRO B 2 39  ? 197.178 273.615 180.705 1.00 111.51 ? 39  PRO B O   1 
ATOM 3043 C CB  . PRO B 2 39  ? 198.028 273.791 183.868 1.00 110.83 ? 39  PRO B CB  1 
ATOM 3044 C CG  . PRO B 2 39  ? 199.018 274.297 184.871 1.00 113.04 ? 39  PRO B CG  1 
ATOM 3045 C CD  . PRO B 2 39  ? 199.739 275.413 184.194 1.00 110.69 ? 39  PRO B CD  1 
ATOM 3046 N N   . ASP B 2 40  ? 197.397 275.749 181.394 1.00 111.37 ? 40  ASP B N   1 
ATOM 3047 C CA  . ASP B 2 40  ? 196.427 276.246 180.426 1.00 112.47 ? 40  ASP B CA  1 
ATOM 3048 C C   . ASP B 2 40  ? 196.887 276.069 178.986 1.00 112.53 ? 40  ASP B C   1 
ATOM 3049 O O   . ASP B 2 40  ? 196.051 276.082 178.076 1.00 110.14 ? 40  ASP B O   1 
ATOM 3050 C CB  . ASP B 2 40  ? 196.107 277.718 180.716 1.00 118.89 ? 40  ASP B CB  1 
ATOM 3051 C CG  . ASP B 2 40  ? 197.228 278.672 180.306 1.00 120.65 ? 40  ASP B CG  1 
ATOM 3052 O OD1 . ASP B 2 40  ? 198.326 278.218 179.918 1.00 118.24 ? 40  ASP B OD1 1 
ATOM 3053 O OD2 . ASP B 2 40  ? 197.002 279.898 180.371 1.00 123.38 ? 40  ASP B OD2 1 
ATOM 3054 N N   . GLU B 2 41  ? 198.187 275.909 178.760 1.00 112.79 ? 41  GLU B N   1 
ATOM 3055 C CA  . GLU B 2 41  ? 198.739 275.784 177.420 1.00 111.68 ? 41  GLU B CA  1 
ATOM 3056 C C   . GLU B 2 41  ? 198.885 274.337 176.969 1.00 112.23 ? 41  GLU B C   1 
ATOM 3057 O O   . GLU B 2 41  ? 199.433 274.093 175.890 1.00 110.96 ? 41  GLU B O   1 
ATOM 3058 C CB  . GLU B 2 41  ? 200.096 276.487 177.344 1.00 105.71 ? 41  GLU B CB  1 
ATOM 3059 N N   . GLN B 2 42  ? 198.414 273.374 177.760 1.00 110.97 ? 42  GLN B N   1 
ATOM 3060 C CA  . GLN B 2 42  ? 198.598 271.968 177.437 1.00 106.18 ? 42  GLN B CA  1 
ATOM 3061 C C   . GLN B 2 42  ? 197.316 271.189 177.688 1.00 104.04 ? 42  GLN B C   1 
ATOM 3062 O O   . GLN B 2 42  ? 196.486 271.568 178.519 1.00 106.24 ? 42  GLN B O   1 
ATOM 3063 C CB  . GLN B 2 42  ? 199.747 271.355 178.246 1.00 101.45 ? 42  GLN B CB  1 
ATOM 3064 C CG  . GLN B 2 42  ? 199.468 271.222 179.729 1.00 104.71 ? 42  GLN B CG  1 
ATOM 3065 C CD  . GLN B 2 42  ? 200.736 271.051 180.534 1.00 110.02 ? 42  GLN B CD  1 
ATOM 3066 O OE1 . GLN B 2 42  ? 200.823 271.484 181.682 1.00 112.39 ? 42  GLN B OE1 1 
ATOM 3067 N NE2 . GLN B 2 42  ? 201.734 270.421 179.929 1.00 105.20 ? 42  GLN B NE2 1 
ATOM 3068 N N   . ARG B 2 43  ? 197.168 270.092 176.948 1.00 104.92 ? 43  ARG B N   1 
ATOM 3069 C CA  . ARG B 2 43  ? 196.044 269.178 177.087 1.00 104.08 ? 43  ARG B CA  1 
ATOM 3070 C C   . ARG B 2 43  ? 196.574 267.751 177.081 1.00 98.28  ? 43  ARG B C   1 
ATOM 3071 O O   . ARG B 2 43  ? 197.649 267.471 176.545 1.00 101.07 ? 43  ARG B O   1 
ATOM 3072 C CB  . ARG B 2 43  ? 195.014 269.362 175.962 1.00 109.81 ? 43  ARG B CB  1 
ATOM 3073 C CG  . ARG B 2 43  ? 194.624 270.809 175.690 1.00 115.14 ? 43  ARG B CG  1 
ATOM 3074 C CD  . ARG B 2 43  ? 194.220 271.012 174.236 1.00 121.61 ? 43  ARG B CD  1 
ATOM 3075 N NE  . ARG B 2 43  ? 194.584 272.337 173.748 1.00 129.30 ? 43  ARG B NE  1 
ATOM 3076 C CZ  . ARG B 2 43  ? 195.228 272.567 172.612 1.00 126.83 ? 43  ARG B CZ  1 
ATOM 3077 N NH1 . ARG B 2 43  ? 195.592 271.580 171.811 1.00 125.44 ? 43  ARG B NH1 1 
ATOM 3078 N NH2 . ARG B 2 43  ? 195.516 273.820 172.272 1.00 118.19 ? 43  ARG B NH2 1 
ATOM 3079 N N   . LEU B 2 44  ? 195.812 266.844 177.690 1.00 90.95  ? 44  LEU B N   1 
ATOM 3080 C CA  . LEU B 2 44  ? 196.175 265.435 177.730 1.00 87.01  ? 44  LEU B CA  1 
ATOM 3081 C C   . LEU B 2 44  ? 194.982 264.571 177.351 1.00 90.12  ? 44  LEU B C   1 
ATOM 3082 O O   . LEU B 2 44  ? 193.832 264.902 177.648 1.00 97.07  ? 44  LEU B O   1 
ATOM 3083 C CB  . LEU B 2 44  ? 196.694 265.008 179.109 1.00 85.39  ? 44  LEU B CB  1 
ATOM 3084 C CG  . LEU B 2 44  ? 197.772 265.870 179.764 1.00 88.85  ? 44  LEU B CG  1 
ATOM 3085 C CD1 . LEU B 2 44  ? 197.146 266.897 180.678 1.00 90.79  ? 44  LEU B CD1 1 
ATOM 3086 C CD2 . LEU B 2 44  ? 198.756 264.999 180.526 1.00 89.02  ? 44  LEU B CD2 1 
ATOM 3087 N N   . TYR B 2 45  ? 195.277 263.455 176.693 1.00 88.54  ? 45  TYR B N   1 
ATOM 3088 C CA  . TYR B 2 45  ? 194.247 262.522 176.251 1.00 88.22  ? 45  TYR B CA  1 
ATOM 3089 C C   . TYR B 2 45  ? 194.618 261.079 176.578 1.00 74.08  ? 45  TYR B C   1 
ATOM 3090 O O   . TYR B 2 45  ? 195.778 260.684 176.465 1.00 72.91  ? 45  TYR B O   1 
ATOM 3091 C CB  . TYR B 2 45  ? 194.002 262.671 174.749 1.00 89.06  ? 45  TYR B CB  1 
ATOM 3092 C CG  . TYR B 2 45  ? 194.037 264.101 174.268 1.00 92.91  ? 45  TYR B CG  1 
ATOM 3093 C CD1 . TYR B 2 45  ? 192.961 264.951 174.476 1.00 98.33  ? 45  TYR B CD1 1 
ATOM 3094 C CD2 . TYR B 2 45  ? 195.148 264.602 173.609 1.00 88.82  ? 45  TYR B CD2 1 
ATOM 3095 C CE1 . TYR B 2 45  ? 192.992 266.261 174.039 1.00 102.03 ? 45  TYR B CE1 1 
ATOM 3096 C CE2 . TYR B 2 45  ? 195.188 265.908 173.167 1.00 94.32  ? 45  TYR B CE2 1 
ATOM 3097 C CZ  . TYR B 2 45  ? 194.110 266.733 173.384 1.00 102.86 ? 45  TYR B CZ  1 
ATOM 3098 O OH  . TYR B 2 45  ? 194.150 268.035 172.944 1.00 108.35 ? 45  TYR B OH  1 
ATOM 3099 N N   . ASP B 2 53  ? 189.976 267.260 182.270 1.00 108.69 ? 53  ASP B N   1 
ATOM 3100 C CA  . ASP B 2 53  ? 190.341 268.622 182.638 1.00 115.81 ? 53  ASP B CA  1 
ATOM 3101 C C   . ASP B 2 53  ? 190.330 268.807 184.153 1.00 113.23 ? 53  ASP B C   1 
ATOM 3102 O O   . ASP B 2 53  ? 191.358 269.109 184.757 1.00 110.57 ? 53  ASP B O   1 
ATOM 3103 C CB  . ASP B 2 53  ? 189.397 269.626 181.973 1.00 124.67 ? 53  ASP B CB  1 
ATOM 3104 C CG  . ASP B 2 53  ? 187.943 269.213 182.073 1.00 132.15 ? 53  ASP B CG  1 
ATOM 3105 O OD1 . ASP B 2 53  ? 187.681 268.023 182.344 1.00 130.56 ? 53  ASP B OD1 1 
ATOM 3106 O OD2 . ASP B 2 53  ? 187.063 270.079 181.885 1.00 134.83 ? 53  ASP B OD2 1 
ATOM 3107 N N   . GLY B 2 54  ? 189.161 268.628 184.760 1.00 114.56 ? 54  GLY B N   1 
ATOM 3108 C CA  . GLY B 2 54  ? 189.030 268.735 186.199 1.00 117.16 ? 54  GLY B CA  1 
ATOM 3109 C C   . GLY B 2 54  ? 188.588 267.434 186.834 1.00 123.94 ? 54  GLY B C   1 
ATOM 3110 O O   . GLY B 2 54  ? 188.699 267.258 188.051 1.00 126.24 ? 54  GLY B O   1 
ATOM 3111 N N   . LYS B 2 55  ? 188.081 266.517 186.016 1.00 122.30 ? 55  LYS B N   1 
ATOM 3112 C CA  . LYS B 2 55  ? 187.670 265.213 186.515 1.00 119.93 ? 55  LYS B CA  1 
ATOM 3113 C C   . LYS B 2 55  ? 188.883 264.421 186.988 1.00 120.87 ? 55  LYS B C   1 
ATOM 3114 O O   . LYS B 2 55  ? 189.918 264.384 186.319 1.00 120.98 ? 55  LYS B O   1 
ATOM 3115 C CB  . LYS B 2 55  ? 186.926 264.442 185.425 1.00 110.63 ? 55  LYS B CB  1 
ATOM 3116 N N   . THR B 2 56  ? 188.751 263.785 188.148 1.00 118.00 ? 56  THR B N   1 
ATOM 3117 C CA  . THR B 2 56  ? 189.864 263.045 188.718 1.00 117.42 ? 56  THR B CA  1 
ATOM 3118 C C   . THR B 2 56  ? 190.093 261.741 187.961 1.00 118.37 ? 56  THR B C   1 
ATOM 3119 O O   . THR B 2 56  ? 189.240 261.268 187.206 1.00 118.81 ? 56  THR B O   1 
ATOM 3120 C CB  . THR B 2 56  ? 189.627 262.747 190.198 1.00 120.11 ? 56  THR B CB  1 
ATOM 3121 O OG1 . THR B 2 56  ? 190.731 261.994 190.712 1.00 125.98 ? 56  THR B OG1 1 
ATOM 3122 C CG2 . THR B 2 56  ? 188.357 261.941 190.381 1.00 120.69 ? 56  THR B CG2 1 
ATOM 3123 N N   . LEU B 2 57  ? 191.271 261.155 188.185 1.00 118.17 ? 57  LEU B N   1 
ATOM 3124 C CA  . LEU B 2 57  ? 191.676 259.945 187.480 1.00 114.83 ? 57  LEU B CA  1 
ATOM 3125 C C   . LEU B 2 57  ? 190.811 258.739 187.817 1.00 119.66 ? 57  LEU B C   1 
ATOM 3126 O O   . LEU B 2 57  ? 190.861 257.746 187.083 1.00 117.56 ? 57  LEU B O   1 
ATOM 3127 C CB  . LEU B 2 57  ? 193.138 259.625 187.789 1.00 111.02 ? 57  LEU B CB  1 
ATOM 3128 C CG  . LEU B 2 57  ? 194.174 260.217 186.836 1.00 107.00 ? 57  LEU B CG  1 
ATOM 3129 C CD1 . LEU B 2 57  ? 194.556 261.615 187.277 1.00 109.56 ? 57  LEU B CD1 1 
ATOM 3130 C CD2 . LEU B 2 57  ? 195.397 259.325 186.768 1.00 106.16 ? 57  LEU B CD2 1 
ATOM 3131 N N   . GLY B 2 58  ? 190.036 258.794 188.902 1.00 123.59 ? 58  GLY B N   1 
ATOM 3132 C CA  . GLY B 2 58  ? 189.190 257.665 189.250 1.00 126.41 ? 58  GLY B CA  1 
ATOM 3133 C C   . GLY B 2 58  ? 188.186 257.330 188.164 1.00 130.70 ? 58  GLY B C   1 
ATOM 3134 O O   . GLY B 2 58  ? 187.979 256.159 187.836 1.00 131.95 ? 58  GLY B O   1 
ATOM 3135 N N   . GLU B 2 59  ? 187.554 258.349 187.589 1.00 131.29 ? 59  GLU B N   1 
ATOM 3136 C CA  . GLU B 2 59  ? 186.620 258.161 186.489 1.00 130.05 ? 59  GLU B CA  1 
ATOM 3137 C C   . GLU B 2 59  ? 187.270 258.339 185.125 1.00 127.30 ? 59  GLU B C   1 
ATOM 3138 O O   . GLU B 2 59  ? 186.571 258.276 184.109 1.00 129.84 ? 59  GLU B O   1 
ATOM 3139 C CB  . GLU B 2 59  ? 185.439 259.126 186.624 1.00 129.65 ? 59  GLU B CB  1 
ATOM 3140 C CG  . GLU B 2 59  ? 185.814 260.587 186.477 1.00 127.50 ? 59  GLU B CG  1 
ATOM 3141 C CD  . GLU B 2 59  ? 186.040 261.261 187.812 1.00 127.33 ? 59  GLU B CD  1 
ATOM 3142 O OE1 . GLU B 2 59  ? 185.709 260.652 188.851 1.00 126.96 ? 59  GLU B OE1 1 
ATOM 3143 O OE2 . GLU B 2 59  ? 186.546 262.401 187.824 1.00 126.96 ? 59  GLU B OE2 1 
ATOM 3144 N N   . CYS B 2 60  ? 188.581 258.557 185.077 1.00 122.04 ? 60  CYS B N   1 
ATOM 3145 C CA  . CYS B 2 60  ? 189.294 258.731 183.820 1.00 121.45 ? 60  CYS B CA  1 
ATOM 3146 C C   . CYS B 2 60  ? 189.779 257.414 183.230 1.00 119.58 ? 60  CYS B C   1 
ATOM 3147 O O   . CYS B 2 60  ? 190.476 257.428 182.211 1.00 118.86 ? 60  CYS B O   1 
ATOM 3148 C CB  . CYS B 2 60  ? 190.482 259.677 184.015 1.00 122.94 ? 60  CYS B CB  1 
ATOM 3149 S SG  . CYS B 2 60  ? 190.036 261.425 184.115 1.00 133.38 ? 60  CYS B SG  1 
ATOM 3150 N N   . GLY B 2 61  ? 189.432 256.285 183.842 1.00 119.38 ? 61  GLY B N   1 
ATOM 3151 C CA  . GLY B 2 61  ? 189.850 254.992 183.344 1.00 118.97 ? 61  GLY B CA  1 
ATOM 3152 C C   . GLY B 2 61  ? 191.228 254.551 183.776 1.00 119.86 ? 61  GLY B C   1 
ATOM 3153 O O   . GLY B 2 61  ? 191.693 253.499 183.323 1.00 120.49 ? 61  GLY B O   1 
ATOM 3154 N N   . PHE B 2 62  ? 191.897 255.317 184.635 1.00 119.36 ? 62  PHE B N   1 
ATOM 3155 C CA  . PHE B 2 62  ? 193.238 254.965 185.103 1.00 114.53 ? 62  PHE B CA  1 
ATOM 3156 C C   . PHE B 2 62  ? 193.131 254.180 186.410 1.00 116.72 ? 62  PHE B C   1 
ATOM 3157 O O   . PHE B 2 62  ? 193.395 254.676 187.506 1.00 112.59 ? 62  PHE B O   1 
ATOM 3158 C CB  . PHE B 2 62  ? 194.089 256.216 185.262 1.00 108.26 ? 62  PHE B CB  1 
ATOM 3159 C CG  . PHE B 2 62  ? 194.408 256.898 183.965 1.00 104.98 ? 62  PHE B CG  1 
ATOM 3160 C CD1 . PHE B 2 62  ? 193.518 257.797 183.403 1.00 107.44 ? 62  PHE B CD1 1 
ATOM 3161 C CD2 . PHE B 2 62  ? 195.592 256.635 183.303 1.00 99.31  ? 62  PHE B CD2 1 
ATOM 3162 C CE1 . PHE B 2 62  ? 193.807 258.422 182.208 1.00 100.71 ? 62  PHE B CE1 1 
ATOM 3163 C CE2 . PHE B 2 62  ? 195.886 257.258 182.109 1.00 95.98  ? 62  PHE B CE2 1 
ATOM 3164 C CZ  . PHE B 2 62  ? 194.991 258.152 181.561 1.00 93.27  ? 62  PHE B CZ  1 
ATOM 3165 N N   . THR B 2 63  ? 192.722 252.923 186.271 1.00 120.77 ? 63  THR B N   1 
ATOM 3166 C CA  . THR B 2 63  ? 192.609 252.041 187.419 1.00 120.51 ? 63  THR B CA  1 
ATOM 3167 C C   . THR B 2 63  ? 193.986 251.543 187.848 1.00 118.14 ? 63  THR B C   1 
ATOM 3168 O O   . THR B 2 63  ? 194.937 251.504 187.064 1.00 117.84 ? 63  THR B O   1 
ATOM 3169 C CB  . THR B 2 63  ? 191.695 250.856 187.107 1.00 120.92 ? 63  THR B CB  1 
ATOM 3170 O OG1 . THR B 2 63  ? 191.485 250.087 188.298 1.00 123.46 ? 63  THR B OG1 1 
ATOM 3171 C CG2 . THR B 2 63  ? 192.313 249.970 186.042 1.00 117.26 ? 63  THR B CG2 1 
ATOM 3172 N N   . SER B 2 64  ? 194.084 251.164 189.123 1.00 115.55 ? 64  SER B N   1 
ATOM 3173 C CA  . SER B 2 64  ? 195.350 250.681 189.657 1.00 110.18 ? 64  SER B CA  1 
ATOM 3174 C C   . SER B 2 64  ? 195.727 249.311 189.115 1.00 111.71 ? 64  SER B C   1 
ATOM 3175 O O   . SER B 2 64  ? 196.902 248.934 189.184 1.00 111.41 ? 64  SER B O   1 
ATOM 3176 C CB  . SER B 2 64  ? 195.294 250.636 191.184 1.00 110.89 ? 64  SER B CB  1 
ATOM 3177 O OG  . SER B 2 64  ? 196.466 250.046 191.715 1.00 112.93 ? 64  SER B OG  1 
ATOM 3178 N N   . GLN B 2 65  ? 194.764 248.555 188.586 1.00 114.41 ? 65  GLN B N   1 
ATOM 3179 C CA  . GLN B 2 65  ? 195.072 247.229 188.063 1.00 116.80 ? 65  GLN B CA  1 
ATOM 3180 C C   . GLN B 2 65  ? 195.847 247.315 186.753 1.00 118.47 ? 65  GLN B C   1 
ATOM 3181 O O   . GLN B 2 65  ? 196.853 246.620 186.570 1.00 116.66 ? 65  GLN B O   1 
ATOM 3182 C CB  . GLN B 2 65  ? 193.783 246.429 187.877 1.00 113.92 ? 65  GLN B CB  1 
ATOM 3183 N N   . THR B 2 66  ? 195.397 248.165 185.831 1.00 116.37 ? 66  THR B N   1 
ATOM 3184 C CA  . THR B 2 66  ? 196.006 248.257 184.510 1.00 114.21 ? 66  THR B CA  1 
ATOM 3185 C C   . THR B 2 66  ? 197.147 249.261 184.438 1.00 105.97 ? 66  THR B C   1 
ATOM 3186 O O   . THR B 2 66  ? 197.839 249.313 183.416 1.00 106.78 ? 66  THR B O   1 
ATOM 3187 C CB  . THR B 2 66  ? 194.951 248.624 183.461 1.00 117.21 ? 66  THR B CB  1 
ATOM 3188 O OG1 . THR B 2 66  ? 194.530 249.980 183.658 1.00 116.71 ? 66  THR B OG1 1 
ATOM 3189 C CG2 . THR B 2 66  ? 193.749 247.700 183.569 1.00 111.99 ? 66  THR B CG2 1 
ATOM 3190 N N   . ALA B 2 67  ? 197.364 250.053 185.483 1.00 100.45 ? 67  ALA B N   1 
ATOM 3191 C CA  . ALA B 2 67  ? 198.442 251.033 185.525 1.00 98.05  ? 67  ALA B CA  1 
ATOM 3192 C C   . ALA B 2 67  ? 199.521 250.622 186.521 1.00 95.41  ? 67  ALA B C   1 
ATOM 3193 O O   . ALA B 2 67  ? 200.087 251.455 187.230 1.00 93.45  ? 67  ALA B O   1 
ATOM 3194 C CB  . ALA B 2 67  ? 197.901 252.419 185.860 1.00 100.11 ? 67  ALA B CB  1 
ATOM 3195 N N   . ARG B 2 68  ? 199.812 249.325 186.579 1.00 93.15  ? 68  ARG B N   1 
ATOM 3196 C CA  . ARG B 2 68  ? 200.816 248.821 187.497 1.00 86.98  ? 68  ARG B CA  1 
ATOM 3197 C C   . ARG B 2 68  ? 202.189 249.388 187.139 1.00 85.83  ? 68  ARG B C   1 
ATOM 3198 O O   . ARG B 2 68  ? 202.450 249.709 185.979 1.00 88.96  ? 68  ARG B O   1 
ATOM 3199 C CB  . ARG B 2 68  ? 200.851 247.296 187.458 1.00 87.12  ? 68  ARG B CB  1 
ATOM 3200 N N   . PRO B 2 69  ? 203.082 249.530 188.122 1.00 80.63  ? 69  PRO B N   1 
ATOM 3201 C CA  . PRO B 2 69  ? 204.393 250.130 187.833 1.00 77.69  ? 69  PRO B CA  1 
ATOM 3202 C C   . PRO B 2 69  ? 205.223 249.329 186.850 1.00 82.42  ? 69  PRO B C   1 
ATOM 3203 O O   . PRO B 2 69  ? 206.156 249.882 186.259 1.00 86.80  ? 69  PRO B O   1 
ATOM 3204 C CB  . PRO B 2 69  ? 205.062 250.197 189.211 1.00 76.38  ? 69  PRO B CB  1 
ATOM 3205 C CG  . PRO B 2 69  ? 204.388 249.137 190.007 1.00 83.78  ? 69  PRO B CG  1 
ATOM 3206 C CD  . PRO B 2 69  ? 202.968 249.107 189.528 1.00 86.56  ? 69  PRO B CD  1 
ATOM 3207 N N   . GLN B 2 70  ? 204.919 248.048 186.656 1.00 84.82  ? 70  GLN B N   1 
ATOM 3208 C CA  . GLN B 2 70  ? 205.619 247.256 185.656 1.00 86.96  ? 70  GLN B CA  1 
ATOM 3209 C C   . GLN B 2 70  ? 205.051 247.437 184.254 1.00 87.76  ? 70  GLN B C   1 
ATOM 3210 O O   . GLN B 2 70  ? 205.666 246.966 183.291 1.00 85.15  ? 70  GLN B O   1 
ATOM 3211 C CB  . GLN B 2 70  ? 205.585 245.777 186.045 1.00 86.16  ? 70  GLN B CB  1 
ATOM 3212 C CG  . GLN B 2 70  ? 204.194 245.167 186.066 1.00 87.08  ? 70  GLN B CG  1 
ATOM 3213 C CD  . GLN B 2 70  ? 203.597 245.139 187.457 1.00 89.52  ? 70  GLN B CD  1 
ATOM 3214 O OE1 . GLN B 2 70  ? 203.785 246.066 188.244 1.00 91.55  ? 70  GLN B OE1 1 
ATOM 3215 N NE2 . GLN B 2 70  ? 202.873 244.073 187.767 1.00 91.86  ? 70  GLN B NE2 1 
ATOM 3216 N N   . ALA B 2 71  ? 203.909 248.110 184.116 1.00 89.52  ? 71  ALA B N   1 
ATOM 3217 C CA  . ALA B 2 71  ? 203.342 248.413 182.808 1.00 88.29  ? 71  ALA B CA  1 
ATOM 3218 C C   . ALA B 2 71  ? 202.343 249.565 182.881 1.00 89.94  ? 71  ALA B C   1 
ATOM 3219 O O   . ALA B 2 71  ? 201.147 249.352 182.648 1.00 91.95  ? 71  ALA B O   1 
ATOM 3220 C CB  . ALA B 2 71  ? 202.662 247.176 182.222 1.00 88.97  ? 71  ALA B CB  1 
ATOM 3221 N N   . PRO B 2 72  ? 202.774 250.785 183.204 1.00 88.79  ? 72  PRO B N   1 
ATOM 3222 C CA  . PRO B 2 72  ? 201.848 251.919 183.169 1.00 88.02  ? 72  PRO B CA  1 
ATOM 3223 C C   . PRO B 2 72  ? 201.379 252.226 181.759 1.00 87.38  ? 72  PRO B C   1 
ATOM 3224 O O   . PRO B 2 72  ? 202.081 251.980 180.776 1.00 87.79  ? 72  PRO B O   1 
ATOM 3225 C CB  . PRO B 2 72  ? 202.683 253.075 183.731 1.00 83.58  ? 72  PRO B CB  1 
ATOM 3226 C CG  . PRO B 2 72  ? 204.091 252.657 183.527 1.00 77.11  ? 72  PRO B CG  1 
ATOM 3227 C CD  . PRO B 2 72  ? 204.074 251.186 183.764 1.00 82.75  ? 72  PRO B CD  1 
ATOM 3228 N N   . ALA B 2 73  ? 200.169 252.772 181.672 1.00 85.05  ? 73  ALA B N   1 
ATOM 3229 C CA  . ALA B 2 73  ? 199.615 253.213 180.404 1.00 80.86  ? 73  ALA B CA  1 
ATOM 3230 C C   . ALA B 2 73  ? 200.100 254.619 180.066 1.00 75.77  ? 73  ALA B C   1 
ATOM 3231 O O   . ALA B 2 73  ? 200.549 255.378 180.929 1.00 78.06  ? 73  ALA B O   1 
ATOM 3232 C CB  . ALA B 2 73  ? 198.088 253.184 180.437 1.00 78.78  ? 73  ALA B CB  1 
ATOM 3233 N N   . THR B 2 74  ? 199.988 254.962 178.788 1.00 71.12  ? 74  THR B N   1 
ATOM 3234 C CA  . THR B 2 74  ? 200.480 256.219 178.250 1.00 69.32  ? 74  THR B CA  1 
ATOM 3235 C C   . THR B 2 74  ? 199.348 257.226 178.110 1.00 69.24  ? 74  THR B C   1 
ATOM 3236 O O   . THR B 2 74  ? 198.198 256.863 177.848 1.00 76.94  ? 74  THR B O   1 
ATOM 3237 C CB  . THR B 2 74  ? 201.133 256.004 176.884 1.00 71.70  ? 74  THR B CB  1 
ATOM 3238 O OG1 . THR B 2 74  ? 200.132 255.613 175.936 1.00 78.92  ? 74  THR B OG1 1 
ATOM 3239 C CG2 . THR B 2 74  ? 202.182 254.919 176.967 1.00 74.16  ? 74  THR B CG2 1 
ATOM 3240 N N   . VAL B 2 75  ? 199.688 258.500 178.287 1.00 61.61  ? 75  VAL B N   1 
ATOM 3241 C CA  . VAL B 2 75  ? 198.782 259.607 178.012 1.00 61.94  ? 75  VAL B CA  1 
ATOM 3242 C C   . VAL B 2 75  ? 199.434 260.499 176.964 1.00 68.48  ? 75  VAL B C   1 
ATOM 3243 O O   . VAL B 2 75  ? 200.656 260.683 176.963 1.00 69.75  ? 75  VAL B O   1 
ATOM 3244 C CB  . VAL B 2 75  ? 198.430 260.402 179.289 1.00 57.28  ? 75  VAL B CB  1 
ATOM 3245 C CG1 . VAL B 2 75  ? 198.114 259.454 180.430 1.00 63.16  ? 75  VAL B CG1 1 
ATOM 3246 C CG2 . VAL B 2 75  ? 199.549 261.341 179.683 1.00 59.81  ? 75  VAL B CG2 1 
ATOM 3247 N N   . GLY B 2 76  ? 198.625 261.010 176.041 1.00 71.41  ? 76  GLY B N   1 
ATOM 3248 C CA  . GLY B 2 76  ? 199.146 261.874 175.003 1.00 67.86  ? 76  GLY B CA  1 
ATOM 3249 C C   . GLY B 2 76  ? 199.050 263.334 175.383 1.00 73.78  ? 76  GLY B C   1 
ATOM 3250 O O   . GLY B 2 76  ? 197.954 263.832 175.650 1.00 85.56  ? 76  GLY B O   1 
ATOM 3251 N N   . LEU B 2 77  ? 200.184 264.027 175.414 1.00 73.21  ? 77  LEU B N   1 
ATOM 3252 C CA  . LEU B 2 77  ? 200.258 265.422 175.824 1.00 79.27  ? 77  LEU B CA  1 
ATOM 3253 C C   . LEU B 2 77  ? 200.472 266.292 174.593 1.00 83.66  ? 77  LEU B C   1 
ATOM 3254 O O   . LEU B 2 77  ? 201.352 266.009 173.774 1.00 87.44  ? 77  LEU B O   1 
ATOM 3255 C CB  . LEU B 2 77  ? 201.396 265.633 176.827 1.00 77.01  ? 77  LEU B CB  1 
ATOM 3256 C CG  . LEU B 2 77  ? 201.913 267.040 177.149 1.00 80.96  ? 77  LEU B CG  1 
ATOM 3257 C CD1 . LEU B 2 77  ? 200.784 268.027 177.395 1.00 88.75  ? 77  LEU B CD1 1 
ATOM 3258 C CD2 . LEU B 2 77  ? 202.859 267.011 178.335 1.00 80.13  ? 77  LEU B CD2 1 
ATOM 3259 N N   . ALA B 2 78  ? 199.673 267.348 174.470 1.00 87.51  ? 78  ALA B N   1 
ATOM 3260 C CA  . ALA B 2 78  ? 199.810 268.317 173.395 1.00 92.43  ? 78  ALA B CA  1 
ATOM 3261 C C   . ALA B 2 78  ? 199.903 269.714 173.987 1.00 91.05  ? 78  ALA B C   1 
ATOM 3262 O O   . ALA B 2 78  ? 199.356 269.988 175.057 1.00 97.10  ? 78  ALA B O   1 
ATOM 3263 C CB  . ALA B 2 78  ? 198.637 268.242 172.411 1.00 102.21 ? 78  ALA B CB  1 
ATOM 3264 N N   . PHE B 2 79  ? 200.608 270.595 173.285 1.00 88.51  ? 79  PHE B N   1 
ATOM 3265 C CA  . PHE B 2 79  ? 200.758 271.973 173.734 1.00 88.43  ? 79  PHE B CA  1 
ATOM 3266 C C   . PHE B 2 79  ? 199.822 272.898 172.966 1.00 93.43  ? 79  PHE B C   1 
ATOM 3267 O O   . PHE B 2 79  ? 200.262 273.690 172.133 1.00 90.24  ? 79  PHE B O   1 
ATOM 3268 C CB  . PHE B 2 79  ? 202.205 272.439 173.574 1.00 86.85  ? 79  PHE B CB  1 
ATOM 3269 C CG  . PHE B 2 79  ? 203.155 271.815 174.556 1.00 84.26  ? 79  PHE B CG  1 
ATOM 3270 C CD1 . PHE B 2 79  ? 202.691 271.271 175.740 1.00 86.79  ? 79  PHE B CD1 1 
ATOM 3271 C CD2 . PHE B 2 79  ? 204.513 271.774 174.294 1.00 82.40  ? 79  PHE B CD2 1 
ATOM 3272 C CE1 . PHE B 2 79  ? 203.564 270.698 176.643 1.00 89.68  ? 79  PHE B CE1 1 
ATOM 3273 C CE2 . PHE B 2 79  ? 205.390 271.202 175.193 1.00 80.99  ? 79  PHE B CE2 1 
ATOM 3274 C CZ  . PHE B 2 79  ? 204.914 270.664 176.369 1.00 86.10  ? 79  PHE B CZ  1 
ATOM 3275 N N   . GLU B 2 86  ? 198.000 272.133 168.996 1.00 103.41 ? 86  GLU B N   1 
ATOM 3276 C CA  . GLU B 2 86  ? 198.521 271.174 168.030 1.00 107.63 ? 86  GLU B CA  1 
ATOM 3277 C C   . GLU B 2 86  ? 198.006 269.769 168.322 1.00 108.96 ? 86  GLU B C   1 
ATOM 3278 O O   . GLU B 2 86  ? 197.553 269.482 169.429 1.00 114.24 ? 86  GLU B O   1 
ATOM 3279 C CB  . GLU B 2 86  ? 200.051 271.185 168.033 1.00 109.15 ? 86  GLU B CB  1 
ATOM 3280 C CG  . GLU B 2 86  ? 200.674 270.629 169.302 1.00 106.89 ? 86  GLU B CG  1 
ATOM 3281 C CD  . GLU B 2 86  ? 201.935 269.834 169.032 1.00 108.08 ? 86  GLU B CD  1 
ATOM 3282 O OE1 . GLU B 2 86  ? 202.183 269.493 167.858 1.00 110.36 ? 86  GLU B OE1 1 
ATOM 3283 O OE2 . GLU B 2 86  ? 202.678 269.549 169.994 1.00 100.46 ? 86  GLU B OE2 1 
ATOM 3284 N N   . ALA B 2 87  ? 198.075 268.897 167.321 1.00 104.92 ? 87  ALA B N   1 
ATOM 3285 C CA  . ALA B 2 87  ? 197.618 267.527 167.478 1.00 106.14 ? 87  ALA B CA  1 
ATOM 3286 C C   . ALA B 2 87  ? 198.680 266.684 168.180 1.00 106.47 ? 87  ALA B C   1 
ATOM 3287 O O   . ALA B 2 87  ? 199.830 267.097 168.355 1.00 109.64 ? 87  ALA B O   1 
ATOM 3288 C CB  . ALA B 2 87  ? 197.265 266.921 166.121 1.00 101.87 ? 87  ALA B CB  1 
ATOM 3289 N N   . LEU B 2 88  ? 198.279 265.484 168.589 1.00 105.22 ? 88  LEU B N   1 
ATOM 3290 C CA  . LEU B 2 88  ? 199.198 264.573 169.254 1.00 104.80 ? 88  LEU B CA  1 
ATOM 3291 C C   . LEU B 2 88  ? 200.262 264.065 168.291 1.00 105.60 ? 88  LEU B C   1 
ATOM 3292 O O   . LEU B 2 88  ? 200.023 263.889 167.094 1.00 106.25 ? 88  LEU B O   1 
ATOM 3293 C CB  . LEU B 2 88  ? 198.446 263.389 169.858 1.00 102.71 ? 88  LEU B CB  1 
ATOM 3294 C CG  . LEU B 2 88  ? 197.538 263.685 171.049 1.00 98.08  ? 88  LEU B CG  1 
ATOM 3295 C CD1 . LEU B 2 88  ? 197.127 262.390 171.721 1.00 95.07  ? 88  LEU B CD1 1 
ATOM 3296 C CD2 . LEU B 2 88  ? 198.260 264.589 172.032 1.00 92.92  ? 88  LEU B CD2 1 
ATOM 3297 N N   . CYS B 2 89  ? 201.452 263.827 168.835 1.00 102.91 ? 89  CYS B N   1 
ATOM 3298 C CA  . CYS B 2 89  ? 202.553 263.255 168.069 1.00 100.73 ? 89  CYS B CA  1 
ATOM 3299 C C   . CYS B 2 89  ? 203.408 262.456 169.040 1.00 94.34  ? 89  CYS B C   1 
ATOM 3300 O O   . CYS B 2 89  ? 204.126 263.039 169.857 1.00 94.16  ? 89  CYS B O   1 
ATOM 3301 C CB  . CYS B 2 89  ? 203.370 264.340 167.375 1.00 100.15 ? 89  CYS B CB  1 
ATOM 3302 S SG  . CYS B 2 89  ? 204.394 263.743 166.012 1.00 106.56 ? 89  CYS B SG  1 
ATOM 3303 N N   . ILE B 2 90  ? 203.317 261.134 168.966 1.00 89.89  ? 90  ILE B N   1 
ATOM 3304 C CA  . ILE B 2 90  ? 204.065 260.236 169.835 1.00 87.66  ? 90  ILE B CA  1 
ATOM 3305 C C   . ILE B 2 90  ? 204.911 259.345 168.941 1.00 90.36  ? 90  ILE B C   1 
ATOM 3306 O O   . ILE B 2 90  ? 204.389 258.427 168.295 1.00 91.10  ? 90  ILE B O   1 
ATOM 3307 C CB  . ILE B 2 90  ? 203.142 259.401 170.732 1.00 82.37  ? 90  ILE B CB  1 
ATOM 3308 C CG1 . ILE B 2 90  ? 202.380 260.304 171.701 1.00 83.15  ? 90  ILE B CG1 1 
ATOM 3309 C CG2 . ILE B 2 90  ? 203.940 258.360 171.493 1.00 80.91  ? 90  ILE B CG2 1 
ATOM 3310 C CD1 . ILE B 2 90  ? 201.385 259.565 172.565 1.00 73.24  ? 90  ILE B CD1 1 
ATOM 3311 N N   . GLU B 2 91  ? 206.206 259.611 168.894 1.00 93.75  ? 91  GLU B N   1 
ATOM 3312 C CA  . GLU B 2 91  ? 207.097 258.809 168.070 1.00 93.87  ? 91  GLU B CA  1 
ATOM 3313 C C   . GLU B 2 91  ? 207.288 257.441 168.707 1.00 89.88  ? 91  GLU B C   1 
ATOM 3314 O O   . GLU B 2 91  ? 207.714 257.362 169.866 1.00 94.32  ? 91  GLU B O   1 
ATOM 3315 C CB  . GLU B 2 91  ? 208.439 259.512 167.895 1.00 100.64 ? 91  GLU B CB  1 
ATOM 3316 C CG  . GLU B 2 91  ? 208.515 260.426 166.677 1.00 104.01 ? 91  GLU B CG  1 
ATOM 3317 C CD  . GLU B 2 91  ? 207.492 261.548 166.706 1.00 107.90 ? 91  GLU B CD  1 
ATOM 3318 O OE1 . GLU B 2 91  ? 207.130 262.047 165.620 1.00 108.15 ? 91  GLU B OE1 1 
ATOM 3319 O OE2 . GLU B 2 91  ? 207.057 261.941 167.810 1.00 107.59 ? 91  GLU B OE2 1 
ATOM 3320 N N   . PRO B 2 92  ? 206.982 256.352 168.008 1.00 86.50  ? 92  PRO B N   1 
ATOM 3321 C CA  . PRO B 2 92  ? 207.131 255.024 168.610 1.00 90.76  ? 92  PRO B CA  1 
ATOM 3322 C C   . PRO B 2 92  ? 208.585 254.702 168.909 1.00 91.35  ? 92  PRO B C   1 
ATOM 3323 O O   . PRO B 2 92  ? 209.506 255.204 168.261 1.00 92.80  ? 92  PRO B O   1 
ATOM 3324 C CB  . PRO B 2 92  ? 206.563 254.081 167.542 1.00 95.51  ? 92  PRO B CB  1 
ATOM 3325 C CG  . PRO B 2 92  ? 205.726 254.950 166.658 1.00 93.69  ? 92  PRO B CG  1 
ATOM 3326 C CD  . PRO B 2 92  ? 206.386 256.290 166.665 1.00 89.76  ? 92  PRO B CD  1 
ATOM 3327 N N   . PHE B 2 93  ? 208.781 253.854 169.914 1.00 87.13  ? 93  PHE B N   1 
ATOM 3328 C CA  . PHE B 2 93  ? 210.117 253.411 170.269 1.00 88.63  ? 93  PHE B CA  1 
ATOM 3329 C C   . PHE B 2 93  ? 210.715 252.578 169.137 1.00 97.72  ? 93  PHE B C   1 
ATOM 3330 O O   . PHE B 2 93  ? 210.022 252.130 168.220 1.00 98.37  ? 93  PHE B O   1 
ATOM 3331 C CB  . PHE B 2 93  ? 210.089 252.598 171.563 1.00 88.03  ? 93  PHE B CB  1 
ATOM 3332 C CG  . PHE B 2 93  ? 209.518 253.340 172.736 1.00 86.00  ? 93  PHE B CG  1 
ATOM 3333 C CD1 . PHE B 2 93  ? 209.688 254.706 172.862 1.00 90.27  ? 93  PHE B CD1 1 
ATOM 3334 C CD2 . PHE B 2 93  ? 208.815 252.666 173.720 1.00 84.73  ? 93  PHE B CD2 1 
ATOM 3335 C CE1 . PHE B 2 93  ? 209.166 255.387 173.943 1.00 85.19  ? 93  PHE B CE1 1 
ATOM 3336 C CE2 . PHE B 2 93  ? 208.292 253.342 174.802 1.00 86.03  ? 93  PHE B CE2 1 
ATOM 3337 C CZ  . PHE B 2 93  ? 208.468 254.705 174.913 1.00 83.72  ? 93  PHE B CZ  1 
ATOM 3338 N N   . SER B 2 94  ? 212.028 252.378 169.210 1.00 104.40 ? 94  SER B N   1 
ATOM 3339 C CA  . SER B 2 94  ? 212.719 251.596 168.195 1.00 106.31 ? 94  SER B CA  1 
ATOM 3340 C C   . SER B 2 94  ? 212.211 250.160 168.186 1.00 111.40 ? 94  SER B C   1 
ATOM 3341 O O   . SER B 2 94  ? 212.026 249.542 169.237 1.00 115.94 ? 94  SER B O   1 
ATOM 3342 C CB  . SER B 2 94  ? 214.225 251.618 168.446 1.00 112.61 ? 94  SER B CB  1 
ATOM 3343 O OG  . SER B 2 94  ? 214.521 251.222 169.773 1.00 114.82 ? 94  SER B OG  1 
ATOM 3344 N N   . SER B 2 95  ? 211.982 249.633 166.990 1.00 115.43 ? 95  SER B N   1 
ATOM 3345 C CA  . SER B 2 95  ? 211.509 248.264 166.864 1.00 119.08 ? 95  SER B CA  1 
ATOM 3346 C C   . SER B 2 95  ? 212.634 247.285 167.193 1.00 123.83 ? 95  SER B C   1 
ATOM 3347 O O   . SER B 2 95  ? 213.784 247.503 166.798 1.00 124.80 ? 95  SER B O   1 
ATOM 3348 C CB  . SER B 2 95  ? 210.987 248.005 165.453 1.00 121.37 ? 95  SER B CB  1 
ATOM 3349 O OG  . SER B 2 95  ? 210.063 249.004 165.062 1.00 124.34 ? 95  SER B OG  1 
ATOM 3350 N N   . PRO B 2 96  ? 212.339 246.204 167.918 1.00 121.93 ? 96  PRO B N   1 
ATOM 3351 C CA  . PRO B 2 96  ? 213.376 245.217 168.203 1.00 122.62 ? 96  PRO B CA  1 
ATOM 3352 C C   . PRO B 2 96  ? 213.805 244.508 166.932 1.00 125.56 ? 96  PRO B C   1 
ATOM 3353 O O   . PRO B 2 96  ? 213.006 244.347 165.994 1.00 123.06 ? 96  PRO B O   1 
ATOM 3354 C CB  . PRO B 2 96  ? 212.684 244.250 169.180 1.00 123.38 ? 96  PRO B CB  1 
ATOM 3355 C CG  . PRO B 2 96  ? 211.238 244.382 168.864 1.00 119.79 ? 96  PRO B CG  1 
ATOM 3356 C CD  . PRO B 2 96  ? 211.035 245.820 168.483 1.00 118.88 ? 96  PRO B CD  1 
ATOM 3357 N N   . PRO B 2 97  ? 215.052 244.066 166.854 1.00 129.68 ? 97  PRO B N   1 
ATOM 3358 C CA  . PRO B 2 97  ? 215.537 243.380 165.655 1.00 128.39 ? 97  PRO B CA  1 
ATOM 3359 C C   . PRO B 2 97  ? 215.150 241.905 165.675 1.00 129.59 ? 97  PRO B C   1 
ATOM 3360 O O   . PRO B 2 97  ? 214.572 241.396 166.632 1.00 130.38 ? 97  PRO B O   1 
ATOM 3361 C CB  . PRO B 2 97  ? 217.051 243.566 165.743 1.00 125.10 ? 97  PRO B CB  1 
ATOM 3362 C CG  . PRO B 2 97  ? 217.327 243.624 167.206 1.00 124.05 ? 97  PRO B CG  1 
ATOM 3363 C CD  . PRO B 2 97  ? 216.113 244.234 167.863 1.00 128.96 ? 97  PRO B CD  1 
ATOM 3364 N N   . GLU B 2 98  ? 215.480 241.221 164.584 1.00 130.68 ? 98  GLU B N   1 
ATOM 3365 C CA  . GLU B 2 98  ? 215.251 239.791 164.442 1.00 134.36 ? 98  GLU B CA  1 
ATOM 3366 C C   . GLU B 2 98  ? 216.588 239.068 164.378 1.00 140.43 ? 98  GLU B C   1 
ATOM 3367 O O   . GLU B 2 98  ? 217.504 239.500 163.671 1.00 141.68 ? 98  GLU B O   1 
ATOM 3368 C CB  . GLU B 2 98  ? 214.427 239.487 163.187 1.00 129.36 ? 98  GLU B CB  1 
ATOM 3369 N N   . LEU B 2 99  ? 216.700 237.967 165.122 1.00 140.76 ? 99  LEU B N   1 
ATOM 3370 C CA  . LEU B 2 99  ? 217.949 237.231 165.224 1.00 141.00 ? 99  LEU B CA  1 
ATOM 3371 C C   . LEU B 2 99  ? 217.668 235.736 165.289 1.00 143.51 ? 99  LEU B C   1 
ATOM 3372 O O   . LEU B 2 99  ? 216.757 235.307 166.012 1.00 142.31 ? 99  LEU B O   1 
ATOM 3373 C CB  . LEU B 2 99  ? 218.745 237.687 166.456 1.00 138.29 ? 99  LEU B CB  1 
ATOM 3374 C CG  . LEU B 2 99  ? 220.000 236.943 166.907 1.00 136.12 ? 99  LEU B CG  1 
ATOM 3375 C CD1 . LEU B 2 99  ? 221.021 237.937 167.417 1.00 142.55 ? 99  LEU B CD1 1 
ATOM 3376 C CD2 . LEU B 2 99  ? 219.655 235.967 168.010 1.00 138.22 ? 99  LEU B CD2 1 
ATOM 3377 N N   . PRO B 2 100 ? 218.429 234.926 164.554 1.00 146.54 ? 100 PRO B N   1 
ATOM 3378 C CA  . PRO B 2 100 ? 218.135 233.489 164.483 1.00 147.35 ? 100 PRO B CA  1 
ATOM 3379 C C   . PRO B 2 100 ? 218.371 232.792 165.814 1.00 149.67 ? 100 PRO B C   1 
ATOM 3380 O O   . PRO B 2 100 ? 219.131 233.252 166.667 1.00 152.65 ? 100 PRO B O   1 
ATOM 3381 C CB  . PRO B 2 100 ? 219.106 232.980 163.413 1.00 141.50 ? 100 PRO B CB  1 
ATOM 3382 C CG  . PRO B 2 100 ? 220.227 233.963 163.430 1.00 135.81 ? 100 PRO B CG  1 
ATOM 3383 C CD  . PRO B 2 100 ? 219.592 235.291 163.728 1.00 141.01 ? 100 PRO B CD  1 
ATOM 3384 N N   . ASP B 2 101 ? 217.700 231.649 165.975 1.00 148.14 ? 101 ASP B N   1 
ATOM 3385 C CA  . ASP B 2 101 ? 217.781 230.912 167.232 1.00 146.85 ? 101 ASP B CA  1 
ATOM 3386 C C   . ASP B 2 101 ? 219.217 230.512 167.549 1.00 147.59 ? 101 ASP B C   1 
ATOM 3387 O O   . ASP B 2 101 ? 219.659 230.619 168.699 1.00 145.96 ? 101 ASP B O   1 
ATOM 3388 C CB  . ASP B 2 101 ? 216.883 229.676 167.173 1.00 148.48 ? 101 ASP B CB  1 
ATOM 3389 C CG  . ASP B 2 101 ? 215.550 229.958 166.512 1.00 146.91 ? 101 ASP B CG  1 
ATOM 3390 O OD1 . ASP B 2 101 ? 215.060 231.101 166.621 1.00 148.77 ? 101 ASP B OD1 1 
ATOM 3391 O OD2 . ASP B 2 101 ? 214.991 229.035 165.882 1.00 139.39 ? 101 ASP B OD2 1 
ATOM 3392 N N   . VAL B 2 102 ? 219.958 230.054 166.546 1.00 150.96 ? 102 VAL B N   1 
ATOM 3393 C CA  . VAL B 2 102 ? 221.348 229.664 166.737 1.00 153.15 ? 102 VAL B CA  1 
ATOM 3394 C C   . VAL B 2 102 ? 222.202 230.886 167.049 1.00 148.84 ? 102 VAL B C   1 
ATOM 3395 O O   . VAL B 2 102 ? 221.828 232.013 166.726 1.00 148.37 ? 102 VAL B O   1 
ATOM 3396 C CB  . VAL B 2 102 ? 221.890 228.925 165.505 1.00 155.33 ? 102 VAL B CB  1 
ATOM 3397 C CG1 . VAL B 2 102 ? 221.135 227.622 165.295 1.00 153.00 ? 102 VAL B CG1 1 
ATOM 3398 C CG2 . VAL B 2 102 ? 221.789 229.810 164.273 1.00 153.88 ? 102 VAL B CG2 1 
ATOM 3399 N N   . MET C 3 17  ? 214.690 267.984 190.731 1.00 97.73  ? 17  MET C N   1 
ATOM 3400 C CA  . MET C 3 17  ? 214.655 266.695 191.410 1.00 103.26 ? 17  MET C CA  1 
ATOM 3401 C C   . MET C 3 17  ? 214.412 265.563 190.420 1.00 104.08 ? 17  MET C C   1 
ATOM 3402 O O   . MET C 3 17  ? 214.140 264.429 190.813 1.00 105.18 ? 17  MET C O   1 
ATOM 3403 C CB  . MET C 3 17  ? 213.574 266.688 192.492 1.00 100.10 ? 17  MET C CB  1 
ATOM 3404 N N   . TYR C 3 18  ? 214.513 265.878 189.132 1.00 99.19  ? 18  TYR C N   1 
ATOM 3405 C CA  . TYR C 3 18  ? 214.294 264.915 188.062 1.00 95.28  ? 18  TYR C CA  1 
ATOM 3406 C C   . TYR C 3 18  ? 215.546 264.809 187.204 1.00 94.73  ? 18  TYR C C   1 
ATOM 3407 O O   . TYR C 3 18  ? 216.218 265.811 186.943 1.00 99.43  ? 18  TYR C O   1 
ATOM 3408 C CB  . TYR C 3 18  ? 213.096 265.314 187.196 1.00 98.21  ? 18  TYR C CB  1 
ATOM 3409 C CG  . TYR C 3 18  ? 211.760 264.901 187.772 1.00 100.12 ? 18  TYR C CG  1 
ATOM 3410 C CD1 . TYR C 3 18  ? 211.309 263.594 187.660 1.00 94.39  ? 18  TYR C CD1 1 
ATOM 3411 C CD2 . TYR C 3 18  ? 210.953 265.818 188.428 1.00 101.68 ? 18  TYR C CD2 1 
ATOM 3412 C CE1 . TYR C 3 18  ? 210.093 263.213 188.184 1.00 96.10  ? 18  TYR C CE1 1 
ATOM 3413 C CE2 . TYR C 3 18  ? 209.734 265.446 188.956 1.00 99.25  ? 18  TYR C CE2 1 
ATOM 3414 C CZ  . TYR C 3 18  ? 209.309 264.142 188.831 1.00 101.93 ? 18  TYR C CZ  1 
ATOM 3415 O OH  . TYR C 3 18  ? 208.095 263.765 189.355 1.00 108.18 ? 18  TYR C OH  1 
ATOM 3416 N N   . VAL C 3 19  ? 215.852 263.592 186.768 1.00 96.49  ? 19  VAL C N   1 
ATOM 3417 C CA  . VAL C 3 19  ? 217.036 263.303 185.972 1.00 95.63  ? 19  VAL C CA  1 
ATOM 3418 C C   . VAL C 3 19  ? 216.595 262.908 184.569 1.00 95.24  ? 19  VAL C C   1 
ATOM 3419 O O   . VAL C 3 19  ? 215.617 262.168 184.390 1.00 94.63  ? 19  VAL C O   1 
ATOM 3420 C CB  . VAL C 3 19  ? 217.896 262.205 186.629 1.00 96.48  ? 19  VAL C CB  1 
ATOM 3421 C CG1 . VAL C 3 19  ? 217.024 261.056 187.070 1.00 98.65  ? 19  VAL C CG1 1 
ATOM 3422 C CG2 . VAL C 3 19  ? 218.993 261.731 185.689 1.00 88.51  ? 19  VAL C CG2 1 
ATOM 3423 N N   . LYS C 3 20  ? 217.319 263.416 183.576 1.00 97.10  ? 20  LYS C N   1 
ATOM 3424 C CA  . LYS C 3 20  ? 216.939 263.364 182.172 1.00 91.64  ? 20  LYS C CA  1 
ATOM 3425 C C   . LYS C 3 20  ? 217.911 262.455 181.432 1.00 93.35  ? 20  LYS C C   1 
ATOM 3426 O O   . LYS C 3 20  ? 219.129 262.632 181.541 1.00 97.43  ? 20  LYS C O   1 
ATOM 3427 C CB  . LYS C 3 20  ? 216.959 264.785 181.602 1.00 93.03  ? 20  LYS C CB  1 
ATOM 3428 C CG  . LYS C 3 20  ? 216.495 264.991 180.179 1.00 94.10  ? 20  LYS C CG  1 
ATOM 3429 C CD  . LYS C 3 20  ? 215.731 266.313 180.127 1.00 96.81  ? 20  LYS C CD  1 
ATOM 3430 C CE  . LYS C 3 20  ? 215.400 266.751 178.716 1.00 93.52  ? 20  LYS C CE  1 
ATOM 3431 N NZ  . LYS C 3 20  ? 216.585 266.647 177.822 1.00 93.36  ? 20  LYS C NZ  1 
ATOM 3432 N N   . LEU C 3 21  ? 217.383 261.483 180.687 1.00 85.38  ? 21  LEU C N   1 
ATOM 3433 C CA  . LEU C 3 21  ? 218.201 260.526 179.957 1.00 81.95  ? 21  LEU C CA  1 
ATOM 3434 C C   . LEU C 3 21  ? 217.782 260.501 178.495 1.00 84.86  ? 21  LEU C C   1 
ATOM 3435 O O   . LEU C 3 21  ? 216.619 260.737 178.161 1.00 88.83  ? 21  LEU C O   1 
ATOM 3436 C CB  . LEU C 3 21  ? 218.091 259.116 180.551 1.00 74.18  ? 21  LEU C CB  1 
ATOM 3437 C CG  . LEU C 3 21  ? 217.867 259.002 182.059 1.00 77.67  ? 21  LEU C CG  1 
ATOM 3438 C CD1 . LEU C 3 21  ? 217.510 257.577 182.438 1.00 74.12  ? 21  LEU C CD1 1 
ATOM 3439 C CD2 . LEU C 3 21  ? 219.104 259.453 182.807 1.00 86.36  ? 21  LEU C CD2 1 
ATOM 3440 N N   . ILE C 3 22  ? 218.744 260.208 177.625 1.00 84.13  ? 22  ILE C N   1 
ATOM 3441 C CA  . ILE C 3 22  ? 218.538 260.215 176.183 1.00 83.70  ? 22  ILE C CA  1 
ATOM 3442 C C   . ILE C 3 22  ? 218.900 258.843 175.635 1.00 85.48  ? 22  ILE C C   1 
ATOM 3443 O O   . ILE C 3 22  ? 219.983 258.321 175.922 1.00 92.73  ? 22  ILE C O   1 
ATOM 3444 C CB  . ILE C 3 22  ? 219.373 261.313 175.499 1.00 84.62  ? 22  ILE C CB  1 
ATOM 3445 C CG1 . ILE C 3 22  ? 219.028 262.684 176.080 1.00 88.37  ? 22  ILE C CG1 1 
ATOM 3446 C CG2 . ILE C 3 22  ? 219.149 261.296 173.999 1.00 82.95  ? 22  ILE C CG2 1 
ATOM 3447 C CD1 . ILE C 3 22  ? 220.091 263.243 176.993 1.00 92.11  ? 22  ILE C CD1 1 
ATOM 3448 N N   . SER C 3 23  ? 217.999 258.265 174.846 1.00 77.31  ? 23  SER C N   1 
ATOM 3449 C CA  . SER C 3 23  ? 218.255 256.976 174.225 1.00 76.51  ? 23  SER C CA  1 
ATOM 3450 C C   . SER C 3 23  ? 219.200 257.146 173.037 1.00 85.19  ? 23  SER C C   1 
ATOM 3451 O O   . SER C 3 23  ? 219.684 258.242 172.743 1.00 89.73  ? 23  SER C O   1 
ATOM 3452 C CB  . SER C 3 23  ? 216.944 256.323 173.798 1.00 77.19  ? 23  SER C CB  1 
ATOM 3453 O OG  . SER C 3 23  ? 216.456 256.901 172.602 1.00 84.36  ? 23  SER C OG  1 
ATOM 3454 N N   . SER C 3 24  ? 219.471 256.041 172.341 1.00 84.25  ? 24  SER C N   1 
ATOM 3455 C CA  . SER C 3 24  ? 220.400 256.093 171.217 1.00 82.47  ? 24  SER C CA  1 
ATOM 3456 C C   . SER C 3 24  ? 219.788 256.806 170.019 1.00 79.70  ? 24  SER C C   1 
ATOM 3457 O O   . SER C 3 24  ? 220.490 257.509 169.284 1.00 80.91  ? 24  SER C O   1 
ATOM 3458 C CB  . SER C 3 24  ? 220.841 254.683 170.833 1.00 86.57  ? 24  SER C CB  1 
ATOM 3459 O OG  . SER C 3 24  ? 222.125 254.702 170.235 1.00 90.72  ? 24  SER C OG  1 
ATOM 3460 N N   . ASP C 3 25  ? 218.486 256.640 169.804 1.00 81.92  ? 25  ASP C N   1 
ATOM 3461 C CA  . ASP C 3 25  ? 217.811 257.240 168.661 1.00 87.16  ? 25  ASP C CA  1 
ATOM 3462 C C   . ASP C 3 25  ? 217.239 258.618 168.960 1.00 86.46  ? 25  ASP C C   1 
ATOM 3463 O O   . ASP C 3 25  ? 216.558 259.189 168.102 1.00 85.49  ? 25  ASP C O   1 
ATOM 3464 C CB  . ASP C 3 25  ? 216.696 256.319 168.159 1.00 86.93  ? 25  ASP C CB  1 
ATOM 3465 C CG  . ASP C 3 25  ? 215.965 255.628 169.285 1.00 87.57  ? 25  ASP C CG  1 
ATOM 3466 O OD1 . ASP C 3 25  ? 216.080 256.089 170.438 1.00 88.95  ? 25  ASP C OD1 1 
ATOM 3467 O OD2 . ASP C 3 25  ? 215.274 254.624 169.018 1.00 86.52  ? 25  ASP C OD2 1 
ATOM 3468 N N   . GLY C 3 26  ? 217.489 259.163 170.147 1.00 84.72  ? 26  GLY C N   1 
ATOM 3469 C CA  . GLY C 3 26  ? 217.077 260.511 170.473 1.00 87.22  ? 26  GLY C CA  1 
ATOM 3470 C C   . GLY C 3 26  ? 215.850 260.631 171.349 1.00 87.79  ? 26  GLY C C   1 
ATOM 3471 O O   . GLY C 3 26  ? 215.413 261.757 171.613 1.00 89.91  ? 26  GLY C O   1 
ATOM 3472 N N   . HIS C 3 27  ? 215.281 259.521 171.807 1.00 83.37  ? 27  HIS C N   1 
ATOM 3473 C CA  . HIS C 3 27  ? 214.129 259.600 172.691 1.00 79.93  ? 27  HIS C CA  1 
ATOM 3474 C C   . HIS C 3 27  ? 214.546 260.130 174.055 1.00 76.48  ? 27  HIS C C   1 
ATOM 3475 O O   . HIS C 3 27  ? 215.707 260.029 174.459 1.00 78.76  ? 27  HIS C O   1 
ATOM 3476 C CB  . HIS C 3 27  ? 213.467 258.233 172.835 1.00 79.12  ? 27  HIS C CB  1 
ATOM 3477 C CG  . HIS C 3 27  ? 212.376 257.987 171.843 1.00 84.10  ? 27  HIS C CG  1 
ATOM 3478 N ND1 . HIS C 3 27  ? 212.438 256.982 170.903 1.00 89.92  ? 27  HIS C ND1 1 
ATOM 3479 C CD2 . HIS C 3 27  ? 211.197 258.620 171.640 1.00 86.46  ? 27  HIS C CD2 1 
ATOM 3480 C CE1 . HIS C 3 27  ? 211.343 257.005 170.165 1.00 89.92  ? 27  HIS C CE1 1 
ATOM 3481 N NE2 . HIS C 3 27  ? 210.574 257.989 170.591 1.00 93.14  ? 27  HIS C NE2 1 
ATOM 3482 N N   . GLU C 3 28  ? 213.584 260.704 174.769 1.00 70.65  ? 28  GLU C N   1 
ATOM 3483 C CA  . GLU C 3 28  ? 213.844 261.380 176.030 1.00 71.51  ? 28  GLU C CA  1 
ATOM 3484 C C   . GLU C 3 28  ? 213.065 260.688 177.137 1.00 76.99  ? 28  GLU C C   1 
ATOM 3485 O O   . GLU C 3 28  ? 211.863 260.443 176.992 1.00 81.91  ? 28  GLU C O   1 
ATOM 3486 C CB  . GLU C 3 28  ? 213.442 262.850 175.948 1.00 79.76  ? 28  GLU C CB  1 
ATOM 3487 C CG  . GLU C 3 28  ? 214.346 263.684 175.065 1.00 89.42  ? 28  GLU C CG  1 
ATOM 3488 C CD  . GLU C 3 28  ? 215.249 264.590 175.859 1.00 93.54  ? 28  GLU C CD  1 
ATOM 3489 O OE1 . GLU C 3 28  ? 215.553 264.242 177.017 1.00 85.65  ? 28  GLU C OE1 1 
ATOM 3490 O OE2 . GLU C 3 28  ? 215.642 265.652 175.333 1.00 100.12 ? 28  GLU C OE2 1 
ATOM 3491 N N   . PHE C 3 29  ? 213.746 260.374 178.236 1.00 73.99  ? 29  PHE C N   1 
ATOM 3492 C CA  . PHE C 3 29  ? 213.128 259.735 179.390 1.00 71.74  ? 29  PHE C CA  1 
ATOM 3493 C C   . PHE C 3 29  ? 213.479 260.538 180.633 1.00 76.60  ? 29  PHE C C   1 
ATOM 3494 O O   . PHE C 3 29  ? 214.651 260.624 181.010 1.00 80.49  ? 29  PHE C O   1 
ATOM 3495 C CB  . PHE C 3 29  ? 213.595 258.286 179.533 1.00 68.92  ? 29  PHE C CB  1 
ATOM 3496 C CG  . PHE C 3 29  ? 213.189 257.402 178.389 1.00 71.74  ? 29  PHE C CG  1 
ATOM 3497 C CD1 . PHE C 3 29  ? 213.910 257.395 177.209 1.00 75.11  ? 29  PHE C CD1 1 
ATOM 3498 C CD2 . PHE C 3 29  ? 212.087 256.575 178.494 1.00 74.32  ? 29  PHE C CD2 1 
ATOM 3499 C CE1 . PHE C 3 29  ? 213.536 256.583 176.158 1.00 75.47  ? 29  PHE C CE1 1 
ATOM 3500 C CE2 . PHE C 3 29  ? 211.707 255.765 177.444 1.00 75.47  ? 29  PHE C CE2 1 
ATOM 3501 C CZ  . PHE C 3 29  ? 212.435 255.767 176.276 1.00 74.55  ? 29  PHE C CZ  1 
ATOM 3502 N N   . ILE C 3 30  ? 212.470 261.126 181.264 1.00 75.55  ? 30  ILE C N   1 
ATOM 3503 C CA  . ILE C 3 30  ? 212.644 261.907 182.482 1.00 72.11  ? 30  ILE C CA  1 
ATOM 3504 C C   . ILE C 3 30  ? 212.138 261.065 183.640 1.00 81.64  ? 30  ILE C C   1 
ATOM 3505 O O   . ILE C 3 30  ? 210.977 260.640 183.644 1.00 88.97  ? 30  ILE C O   1 
ATOM 3506 C CB  . ILE C 3 30  ? 211.901 263.247 182.406 1.00 64.07  ? 30  ILE C CB  1 
ATOM 3507 C CG1 . ILE C 3 30  ? 212.563 264.160 181.376 1.00 74.62  ? 30  ILE C CG1 1 
ATOM 3508 C CG2 . ILE C 3 30  ? 211.864 263.911 183.769 1.00 73.89  ? 30  ILE C CG2 1 
ATOM 3509 C CD1 . ILE C 3 30  ? 211.584 264.814 180.431 1.00 81.19  ? 30  ILE C CD1 1 
ATOM 3510 N N   . VAL C 3 31  ? 213.002 260.819 184.624 1.00 81.49  ? 31  VAL C N   1 
ATOM 3511 C CA  . VAL C 3 31  ? 212.662 259.967 185.753 1.00 83.14  ? 31  VAL C CA  1 
ATOM 3512 C C   . VAL C 3 31  ? 213.005 260.697 187.043 1.00 90.38  ? 31  VAL C C   1 
ATOM 3513 O O   . VAL C 3 31  ? 213.695 261.715 187.044 1.00 94.52  ? 31  VAL C O   1 
ATOM 3514 C CB  . VAL C 3 31  ? 213.377 258.602 185.695 1.00 80.84  ? 31  VAL C CB  1 
ATOM 3515 C CG1 . VAL C 3 31  ? 212.685 257.688 184.704 1.00 85.44  ? 31  VAL C CG1 1 
ATOM 3516 C CG2 . VAL C 3 31  ? 214.831 258.786 185.318 1.00 80.59  ? 31  VAL C CG2 1 
ATOM 3517 N N   . LYS C 3 32  ? 212.481 260.180 188.148 1.00 94.54  ? 32  LYS C N   1 
ATOM 3518 C CA  . LYS C 3 32  ? 212.865 260.693 189.454 1.00 99.26  ? 32  LYS C CA  1 
ATOM 3519 C C   . LYS C 3 32  ? 214.308 260.311 189.753 1.00 105.40 ? 32  LYS C C   1 
ATOM 3520 O O   . LYS C 3 32  ? 214.769 259.229 189.381 1.00 109.81 ? 32  LYS C O   1 
ATOM 3521 C CB  . LYS C 3 32  ? 211.934 260.152 190.537 1.00 99.38  ? 32  LYS C CB  1 
ATOM 3522 C CG  . LYS C 3 32  ? 211.650 261.138 191.656 1.00 102.02 ? 32  LYS C CG  1 
ATOM 3523 C CD  . LYS C 3 32  ? 210.514 260.656 192.542 1.00 98.15  ? 32  LYS C CD  1 
ATOM 3524 C CE  . LYS C 3 32  ? 209.186 260.694 191.805 1.00 95.41  ? 32  LYS C CE  1 
ATOM 3525 N NZ  . LYS C 3 32  ? 208.034 260.778 192.744 1.00 88.55  ? 32  LYS C NZ  1 
ATOM 3526 N N   . ARG C 3 33  ? 215.027 261.213 190.424 1.00 103.41 ? 33  ARG C N   1 
ATOM 3527 C CA  . ARG C 3 33  ? 216.437 260.967 190.707 1.00 101.76 ? 33  ARG C CA  1 
ATOM 3528 C C   . ARG C 3 33  ? 216.616 259.741 191.593 1.00 107.27 ? 33  ARG C C   1 
ATOM 3529 O O   . ARG C 3 33  ? 217.551 258.954 191.397 1.00 109.31 ? 33  ARG C O   1 
ATOM 3530 C CB  . ARG C 3 33  ? 217.065 262.199 191.358 1.00 101.79 ? 33  ARG C CB  1 
ATOM 3531 N N   . GLU C 3 34  ? 215.728 259.563 192.573 1.00 108.42 ? 34  GLU C N   1 
ATOM 3532 C CA  . GLU C 3 34  ? 215.821 258.408 193.460 1.00 109.74 ? 34  GLU C CA  1 
ATOM 3533 C C   . GLU C 3 34  ? 215.687 257.104 192.685 1.00 106.35 ? 34  GLU C C   1 
ATOM 3534 O O   . GLU C 3 34  ? 216.423 256.144 192.939 1.00 107.77 ? 34  GLU C O   1 
ATOM 3535 C CB  . GLU C 3 34  ? 214.752 258.499 194.547 1.00 113.80 ? 34  GLU C CB  1 
ATOM 3536 C CG  . GLU C 3 34  ? 215.233 258.102 195.930 1.00 124.30 ? 34  GLU C CG  1 
ATOM 3537 C CD  . GLU C 3 34  ? 214.113 258.082 196.949 1.00 130.67 ? 34  GLU C CD  1 
ATOM 3538 O OE1 . GLU C 3 34  ? 213.337 259.059 197.001 1.00 132.31 ? 34  GLU C OE1 1 
ATOM 3539 O OE2 . GLU C 3 34  ? 214.006 257.088 197.698 1.00 132.36 ? 34  GLU C OE2 1 
ATOM 3540 N N   . HIS C 3 35  ? 214.748 257.048 191.738 1.00 100.98 ? 35  HIS C N   1 
ATOM 3541 C CA  . HIS C 3 35  ? 214.584 255.839 190.938 1.00 98.89  ? 35  HIS C CA  1 
ATOM 3542 C C   . HIS C 3 35  ? 215.817 255.570 190.086 1.00 100.86 ? 35  HIS C C   1 
ATOM 3543 O O   . HIS C 3 35  ? 216.274 254.425 189.990 1.00 100.39 ? 35  HIS C O   1 
ATOM 3544 C CB  . HIS C 3 35  ? 213.341 255.949 190.055 1.00 95.62  ? 35  HIS C CB  1 
ATOM 3545 C CG  . HIS C 3 35  ? 212.090 256.289 190.804 1.00 98.36  ? 35  HIS C CG  1 
ATOM 3546 N ND1 . HIS C 3 35  ? 212.022 256.303 192.180 1.00 100.39 ? 35  HIS C ND1 1 
ATOM 3547 C CD2 . HIS C 3 35  ? 210.853 256.621 190.364 1.00 100.69 ? 35  HIS C CD2 1 
ATOM 3548 C CE1 . HIS C 3 35  ? 210.801 256.636 192.556 1.00 101.82 ? 35  HIS C CE1 1 
ATOM 3549 N NE2 . HIS C 3 35  ? 210.071 256.832 191.473 1.00 103.39 ? 35  HIS C NE2 1 
ATOM 3550 N N   . ALA C 3 36  ? 216.373 256.612 189.463 1.00 100.90 ? 36  ALA C N   1 
ATOM 3551 C CA  . ALA C 3 36  ? 217.544 256.434 188.614 1.00 104.78 ? 36  ALA C CA  1 
ATOM 3552 C C   . ALA C 3 36  ? 218.793 256.089 189.410 1.00 107.96 ? 36  ALA C C   1 
ATOM 3553 O O   . ALA C 3 36  ? 219.731 255.515 188.848 1.00 109.67 ? 36  ALA C O   1 
ATOM 3554 C CB  . ALA C 3 36  ? 217.794 257.691 187.785 1.00 103.11 ? 36  ALA C CB  1 
ATOM 3555 N N   . LEU C 3 37  ? 218.829 256.425 190.699 1.00 108.80 ? 37  LEU C N   1 
ATOM 3556 C CA  . LEU C 3 37  ? 219.975 256.066 191.524 1.00 111.50 ? 37  LEU C CA  1 
ATOM 3557 C C   . LEU C 3 37  ? 220.038 254.575 191.822 1.00 109.36 ? 37  LEU C C   1 
ATOM 3558 O O   . LEU C 3 37  ? 221.024 254.123 192.414 1.00 112.44 ? 37  LEU C O   1 
ATOM 3559 C CB  . LEU C 3 37  ? 219.953 256.859 192.831 1.00 113.45 ? 37  LEU C CB  1 
ATOM 3560 C CG  . LEU C 3 37  ? 220.459 258.299 192.732 1.00 110.94 ? 37  LEU C CG  1 
ATOM 3561 C CD1 . LEU C 3 37  ? 220.597 258.917 194.113 1.00 109.65 ? 37  LEU C CD1 1 
ATOM 3562 C CD2 . LEU C 3 37  ? 221.780 258.352 191.981 1.00 109.18 ? 37  LEU C CD2 1 
ATOM 3563 N N   . THR C 3 38  ? 219.014 253.808 191.439 1.00 106.00 ? 38  THR C N   1 
ATOM 3564 C CA  . THR C 3 38  ? 219.039 252.367 191.663 1.00 108.44 ? 38  THR C CA  1 
ATOM 3565 C C   . THR C 3 38  ? 220.214 251.718 190.943 1.00 107.96 ? 38  THR C C   1 
ATOM 3566 O O   . THR C 3 38  ? 220.918 250.879 191.517 1.00 107.86 ? 38  THR C O   1 
ATOM 3567 C CB  . THR C 3 38  ? 217.719 251.744 191.204 1.00 105.40 ? 38  THR C CB  1 
ATOM 3568 O OG1 . THR C 3 38  ? 216.684 252.071 192.139 1.00 105.89 ? 38  THR C OG1 1 
ATOM 3569 C CG2 . THR C 3 38  ? 217.842 250.233 191.103 1.00 104.31 ? 38  THR C CG2 1 
ATOM 3570 N N   . SER C 3 39  ? 220.450 252.100 189.692 1.00 105.47 ? 39  SER C N   1 
ATOM 3571 C CA  . SER C 3 39  ? 221.566 251.555 188.933 1.00 108.98 ? 39  SER C CA  1 
ATOM 3572 C C   . SER C 3 39  ? 222.870 252.191 189.394 1.00 113.79 ? 39  SER C C   1 
ATOM 3573 O O   . SER C 3 39  ? 222.958 253.414 189.540 1.00 117.24 ? 39  SER C O   1 
ATOM 3574 C CB  . SER C 3 39  ? 221.362 251.788 187.438 1.00 107.78 ? 39  SER C CB  1 
ATOM 3575 O OG  . SER C 3 39  ? 221.429 253.167 187.130 1.00 109.36 ? 39  SER C OG  1 
ATOM 3576 N N   . GLY C 3 40  ? 223.883 251.355 189.622 1.00 112.56 ? 40  GLY C N   1 
ATOM 3577 C CA  . GLY C 3 40  ? 225.155 251.865 190.106 1.00 112.42 ? 40  GLY C CA  1 
ATOM 3578 C C   . GLY C 3 40  ? 225.869 252.740 189.094 1.00 118.17 ? 40  GLY C C   1 
ATOM 3579 O O   . GLY C 3 40  ? 226.530 253.715 189.462 1.00 124.30 ? 40  GLY C O   1 
ATOM 3580 N N   . THR C 3 41  ? 225.761 252.399 187.807 1.00 115.50 ? 41  THR C N   1 
ATOM 3581 C CA  . THR C 3 41  ? 226.478 253.149 186.780 1.00 117.48 ? 41  THR C CA  1 
ATOM 3582 C C   . THR C 3 41  ? 225.977 254.585 186.682 1.00 124.24 ? 41  THR C C   1 
ATOM 3583 O O   . THR C 3 41  ? 226.775 255.514 186.522 1.00 131.13 ? 41  THR C O   1 
ATOM 3584 C CB  . THR C 3 41  ? 226.356 252.446 185.429 1.00 109.29 ? 41  THR C CB  1 
ATOM 3585 O OG1 . THR C 3 41  ? 226.680 251.059 185.581 1.00 106.23 ? 41  THR C OG1 1 
ATOM 3586 C CG2 . THR C 3 41  ? 227.305 253.070 184.421 1.00 108.54 ? 41  THR C CG2 1 
ATOM 3587 N N   . ILE C 3 42  ? 224.662 254.790 186.771 1.00 121.59 ? 42  ILE C N   1 
ATOM 3588 C CA  . ILE C 3 42  ? 224.124 256.146 186.715 1.00 124.26 ? 42  ILE C CA  1 
ATOM 3589 C C   . ILE C 3 42  ? 224.584 256.953 187.924 1.00 129.88 ? 42  ILE C C   1 
ATOM 3590 O O   . ILE C 3 42  ? 224.933 258.134 187.803 1.00 132.69 ? 42  ILE C O   1 
ATOM 3591 C CB  . ILE C 3 42  ? 222.590 256.107 186.600 1.00 117.52 ? 42  ILE C CB  1 
ATOM 3592 C CG1 . ILE C 3 42  ? 222.178 255.616 185.211 1.00 112.57 ? 42  ILE C CG1 1 
ATOM 3593 C CG2 . ILE C 3 42  ? 221.992 257.478 186.875 1.00 117.46 ? 42  ILE C CG2 1 
ATOM 3594 C CD1 . ILE C 3 42  ? 220.685 255.573 184.996 1.00 105.86 ? 42  ILE C CD1 1 
ATOM 3595 N N   . LYS C 3 43  ? 224.595 256.332 189.106 1.00 127.72 ? 43  LYS C N   1 
ATOM 3596 C CA  . LYS C 3 43  ? 225.076 257.020 190.299 1.00 127.95 ? 43  LYS C CA  1 
ATOM 3597 C C   . LYS C 3 43  ? 226.547 257.391 190.165 1.00 131.41 ? 43  LYS C C   1 
ATOM 3598 O O   . LYS C 3 43  ? 226.959 258.485 190.570 1.00 134.30 ? 43  LYS C O   1 
ATOM 3599 C CB  . LYS C 3 43  ? 224.852 256.149 191.535 1.00 124.01 ? 43  LYS C CB  1 
ATOM 3600 N N   . ALA C 3 44  ? 227.356 256.490 189.604 1.00 131.24 ? 44  ALA C N   1 
ATOM 3601 C CA  . ALA C 3 44  ? 228.764 256.800 189.375 1.00 135.73 ? 44  ALA C CA  1 
ATOM 3602 C C   . ALA C 3 44  ? 228.919 257.935 188.372 1.00 138.06 ? 44  ALA C C   1 
ATOM 3603 O O   . ALA C 3 44  ? 229.801 258.790 188.520 1.00 143.12 ? 44  ALA C O   1 
ATOM 3604 C CB  . ALA C 3 44  ? 229.506 255.553 188.896 1.00 136.16 ? 44  ALA C CB  1 
ATOM 3605 N N   . MET C 3 45  ? 228.077 257.953 187.337 1.00 135.31 ? 45  MET C N   1 
ATOM 3606 C CA  . MET C 3 45  ? 228.109 259.043 186.369 1.00 136.08 ? 45  MET C CA  1 
ATOM 3607 C C   . MET C 3 45  ? 227.773 260.373 187.029 1.00 138.31 ? 45  MET C C   1 
ATOM 3608 O O   . MET C 3 45  ? 228.410 261.395 186.748 1.00 143.32 ? 45  MET C O   1 
ATOM 3609 C CB  . MET C 3 45  ? 227.135 258.756 185.226 1.00 134.68 ? 45  MET C CB  1 
ATOM 3610 C CG  . MET C 3 45  ? 227.650 257.767 184.196 1.00 139.68 ? 45  MET C CG  1 
ATOM 3611 S SD  . MET C 3 45  ? 226.873 257.993 182.585 1.00 150.74 ? 45  MET C SD  1 
ATOM 3612 C CE  . MET C 3 45  ? 226.981 256.335 181.920 1.00 120.96 ? 45  MET C CE  1 
ATOM 3613 N N   . LEU C 3 46  ? 226.779 260.379 187.911 1.00 136.20 ? 46  LEU C N   1 
ATOM 3614 C CA  . LEU C 3 46  ? 226.377 261.596 188.608 1.00 133.16 ? 46  LEU C CA  1 
ATOM 3615 C C   . LEU C 3 46  ? 227.305 261.879 189.784 1.00 133.06 ? 46  LEU C C   1 
ATOM 3616 O O   . LEU C 3 46  ? 228.234 262.680 189.676 1.00 131.87 ? 46  LEU C O   1 
ATOM 3617 C CB  . LEU C 3 46  ? 224.929 261.493 189.097 1.00 128.97 ? 46  LEU C CB  1 
ATOM 3618 C CG  . LEU C 3 46  ? 223.768 261.770 188.133 1.00 123.18 ? 46  LEU C CG  1 
ATOM 3619 C CD1 . LEU C 3 46  ? 223.487 263.263 188.067 1.00 126.06 ? 46  LEU C CD1 1 
ATOM 3620 C CD2 . LEU C 3 46  ? 224.001 261.207 186.738 1.00 125.11 ? 46  LEU C CD2 1 
ATOM 3621 N N   . ASN C 3 58  ? 220.033 267.805 185.326 1.00 117.66 ? 58  ASN C N   1 
ATOM 3622 C CA  . ASN C 3 58  ? 221.084 266.917 184.845 1.00 119.50 ? 58  ASN C CA  1 
ATOM 3623 C C   . ASN C 3 58  ? 220.624 266.142 183.618 1.00 111.65 ? 58  ASN C C   1 
ATOM 3624 O O   . ASN C 3 58  ? 219.434 265.885 183.447 1.00 106.87 ? 58  ASN C O   1 
ATOM 3625 C CB  . ASN C 3 58  ? 221.514 265.947 185.947 1.00 127.66 ? 58  ASN C CB  1 
ATOM 3626 C CG  . ASN C 3 58  ? 222.109 266.655 187.147 1.00 132.33 ? 58  ASN C CG  1 
ATOM 3627 O OD1 . ASN C 3 58  ? 222.842 267.633 187.005 1.00 134.44 ? 58  ASN C OD1 1 
ATOM 3628 N ND2 . ASN C 3 58  ? 221.795 266.162 188.340 1.00 129.79 ? 58  ASN C ND2 1 
ATOM 3629 N N   . GLU C 3 59  ? 221.575 265.772 182.764 1.00 109.31 ? 59  GLU C N   1 
ATOM 3630 C CA  . GLU C 3 59  ? 221.285 265.004 181.564 1.00 102.88 ? 59  GLU C CA  1 
ATOM 3631 C C   . GLU C 3 59  ? 222.353 263.939 181.374 1.00 102.50 ? 59  GLU C C   1 
ATOM 3632 O O   . GLU C 3 59  ? 223.542 264.199 181.576 1.00 104.47 ? 59  GLU C O   1 
ATOM 3633 C CB  . GLU C 3 59  ? 221.214 265.904 180.324 1.00 100.33 ? 59  GLU C CB  1 
ATOM 3634 N N   . VAL C 3 60  ? 221.922 262.741 180.989 1.00 100.03 ? 60  VAL C N   1 
ATOM 3635 C CA  . VAL C 3 60  ? 222.818 261.626 180.704 1.00 95.76  ? 60  VAL C CA  1 
ATOM 3636 C C   . VAL C 3 60  ? 222.477 261.099 179.319 1.00 96.65  ? 60  VAL C C   1 
ATOM 3637 O O   . VAL C 3 60  ? 221.321 260.751 179.052 1.00 95.81  ? 60  VAL C O   1 
ATOM 3638 C CB  . VAL C 3 60  ? 222.702 260.508 181.752 1.00 91.26  ? 60  VAL C CB  1 
ATOM 3639 C CG1 . VAL C 3 60  ? 223.470 259.281 181.302 1.00 93.42  ? 60  VAL C CG1 1 
ATOM 3640 C CG2 . VAL C 3 60  ? 223.206 260.990 183.098 1.00 97.02  ? 60  VAL C CG2 1 
ATOM 3641 N N   . ASN C 3 61  ? 223.474 261.036 178.443 1.00 95.55  ? 61  ASN C N   1 
ATOM 3642 C CA  . ASN C 3 61  ? 223.279 260.610 177.064 1.00 93.99  ? 61  ASN C CA  1 
ATOM 3643 C C   . ASN C 3 61  ? 223.775 259.178 176.908 1.00 95.79  ? 61  ASN C C   1 
ATOM 3644 O O   . ASN C 3 61  ? 224.929 258.878 177.232 1.00 101.52 ? 61  ASN C O   1 
ATOM 3645 C CB  . ASN C 3 61  ? 224.011 261.542 176.099 1.00 98.91  ? 61  ASN C CB  1 
ATOM 3646 C CG  . ASN C 3 61  ? 223.551 261.373 174.666 1.00 100.94 ? 61  ASN C CG  1 
ATOM 3647 O OD1 . ASN C 3 61  ? 222.562 260.693 174.396 1.00 96.69  ? 61  ASN C OD1 1 
ATOM 3648 N ND2 . ASN C 3 61  ? 224.268 261.994 173.738 1.00 105.82 ? 61  ASN C ND2 1 
ATOM 3649 N N   . PHE C 3 62  ? 222.905 258.302 176.415 1.00 91.47  ? 62  PHE C N   1 
ATOM 3650 C CA  . PHE C 3 62  ? 223.238 256.905 176.162 1.00 91.78  ? 62  PHE C CA  1 
ATOM 3651 C C   . PHE C 3 62  ? 223.343 256.716 174.655 1.00 95.36  ? 62  PHE C C   1 
ATOM 3652 O O   . PHE C 3 62  ? 222.346 256.848 173.937 1.00 93.69  ? 62  PHE C O   1 
ATOM 3653 C CB  . PHE C 3 62  ? 222.190 255.975 176.765 1.00 85.69  ? 62  PHE C CB  1 
ATOM 3654 C CG  . PHE C 3 62  ? 222.169 255.982 178.264 1.00 85.77  ? 62  PHE C CG  1 
ATOM 3655 C CD1 . PHE C 3 62  ? 223.247 255.504 178.986 1.00 87.69  ? 62  PHE C CD1 1 
ATOM 3656 C CD2 . PHE C 3 62  ? 221.072 256.469 178.951 1.00 85.67  ? 62  PHE C CD2 1 
ATOM 3657 C CE1 . PHE C 3 62  ? 223.230 255.509 180.364 1.00 87.58  ? 62  PHE C CE1 1 
ATOM 3658 C CE2 . PHE C 3 62  ? 221.051 256.477 180.329 1.00 84.00  ? 62  PHE C CE2 1 
ATOM 3659 C CZ  . PHE C 3 62  ? 222.130 255.996 181.036 1.00 85.85  ? 62  PHE C CZ  1 
ATOM 3660 N N   . ARG C 3 63  ? 224.546 256.408 174.179 1.00 96.48  ? 63  ARG C N   1 
ATOM 3661 C CA  . ARG C 3 63  ? 224.802 256.309 172.750 1.00 96.83  ? 63  ARG C CA  1 
ATOM 3662 C C   . ARG C 3 63  ? 224.549 254.919 172.181 1.00 100.06 ? 63  ARG C C   1 
ATOM 3663 O O   . ARG C 3 63  ? 224.578 254.757 170.957 1.00 104.36 ? 63  ARG C O   1 
ATOM 3664 C CB  . ARG C 3 63  ? 226.245 256.726 172.445 1.00 91.94  ? 63  ARG C CB  1 
ATOM 3665 N N   . GLU C 3 64  ? 224.299 253.917 173.024 1.00 92.70  ? 64  GLU C N   1 
ATOM 3666 C CA  . GLU C 3 64  ? 224.108 252.554 172.555 1.00 93.60  ? 64  GLU C CA  1 
ATOM 3667 C C   . GLU C 3 64  ? 222.745 251.968 172.898 1.00 92.40  ? 64  GLU C C   1 
ATOM 3668 O O   . GLU C 3 64  ? 222.211 251.191 172.099 1.00 95.21  ? 64  GLU C O   1 
ATOM 3669 C CB  . GLU C 3 64  ? 225.210 251.640 173.120 1.00 96.17  ? 64  GLU C CB  1 
ATOM 3670 C CG  . GLU C 3 64  ? 225.008 250.147 172.871 1.00 106.42 ? 64  GLU C CG  1 
ATOM 3671 C CD  . GLU C 3 64  ? 225.540 249.690 171.522 1.00 106.24 ? 64  GLU C CD  1 
ATOM 3672 O OE1 . GLU C 3 64  ? 225.714 250.540 170.624 1.00 98.63  ? 64  GLU C OE1 1 
ATOM 3673 O OE2 . GLU C 3 64  ? 225.784 248.475 171.362 1.00 101.23 ? 64  GLU C OE2 1 
ATOM 3674 N N   . ILE C 3 65  ? 222.159 252.328 174.033 1.00 85.08  ? 65  ILE C N   1 
ATOM 3675 C CA  . ILE C 3 65  ? 220.910 251.734 174.497 1.00 78.17  ? 65  ILE C CA  1 
ATOM 3676 C C   . ILE C 3 65  ? 219.778 252.252 173.613 1.00 80.44  ? 65  ILE C C   1 
ATOM 3677 O O   . ILE C 3 65  ? 219.570 253.473 173.551 1.00 82.83  ? 65  ILE C O   1 
ATOM 3678 C CB  . ILE C 3 65  ? 220.648 252.067 175.969 1.00 71.08  ? 65  ILE C CB  1 
ATOM 3679 C CG1 . ILE C 3 65  ? 221.822 251.603 176.830 1.00 71.73  ? 65  ILE C CG1 1 
ATOM 3680 C CG2 . ILE C 3 65  ? 219.354 251.428 176.433 1.00 74.46  ? 65  ILE C CG2 1 
ATOM 3681 C CD1 . ILE C 3 65  ? 221.539 251.619 178.310 1.00 75.02  ? 65  ILE C CD1 1 
ATOM 3682 N N   . PRO C 3 66  ? 219.032 251.383 172.936 1.00 80.55  ? 66  PRO C N   1 
ATOM 3683 C CA  . PRO C 3 66  ? 217.903 251.847 172.124 1.00 78.49  ? 66  PRO C CA  1 
ATOM 3684 C C   . PRO C 3 66  ? 216.722 252.238 172.998 1.00 78.42  ? 66  PRO C C   1 
ATOM 3685 O O   . PRO C 3 66  ? 216.697 252.014 174.209 1.00 78.82  ? 66  PRO C O   1 
ATOM 3686 C CB  . PRO C 3 66  ? 217.568 250.641 171.239 1.00 76.48  ? 66  PRO C CB  1 
ATOM 3687 C CG  . PRO C 3 66  ? 218.692 249.664 171.435 1.00 79.68  ? 66  PRO C CG  1 
ATOM 3688 C CD  . PRO C 3 66  ? 219.254 249.938 172.787 1.00 83.67  ? 66  PRO C CD  1 
ATOM 3689 N N   . SER C 3 67  ? 215.723 252.842 172.350 1.00 77.02  ? 67  SER C N   1 
ATOM 3690 C CA  . SER C 3 67  ? 214.562 253.345 173.077 1.00 76.90  ? 67  SER C CA  1 
ATOM 3691 C C   . SER C 3 67  ? 213.764 252.217 173.718 1.00 76.05  ? 67  SER C C   1 
ATOM 3692 O O   . SER C 3 67  ? 213.343 252.325 174.876 1.00 80.41  ? 67  SER C O   1 
ATOM 3693 C CB  . SER C 3 67  ? 213.674 254.158 172.140 1.00 81.88  ? 67  SER C CB  1 
ATOM 3694 O OG  . SER C 3 67  ? 214.303 255.373 171.779 1.00 88.76  ? 67  SER C OG  1 
ATOM 3695 N N   . HIS C 3 68  ? 213.547 251.123 172.985 1.00 75.42  ? 68  HIS C N   1 
ATOM 3696 C CA  . HIS C 3 68  ? 212.739 250.028 173.507 1.00 79.44  ? 68  HIS C CA  1 
ATOM 3697 C C   . HIS C 3 68  ? 213.420 249.289 174.649 1.00 81.19  ? 68  HIS C C   1 
ATOM 3698 O O   . HIS C 3 68  ? 212.778 248.450 175.289 1.00 82.74  ? 68  HIS C O   1 
ATOM 3699 C CB  . HIS C 3 68  ? 212.387 249.047 172.389 1.00 79.65  ? 68  HIS C CB  1 
ATOM 3700 C CG  . HIS C 3 68  ? 213.573 248.369 171.778 1.00 88.49  ? 68  HIS C CG  1 
ATOM 3701 N ND1 . HIS C 3 68  ? 214.218 248.862 170.665 1.00 89.24  ? 68  HIS C ND1 1 
ATOM 3702 C CD2 . HIS C 3 68  ? 214.223 247.232 172.117 1.00 91.88  ? 68  HIS C CD2 1 
ATOM 3703 C CE1 . HIS C 3 68  ? 215.219 248.060 170.348 1.00 90.75  ? 68  HIS C CE1 1 
ATOM 3704 N NE2 . HIS C 3 68  ? 215.244 247.063 171.214 1.00 94.62  ? 68  HIS C NE2 1 
ATOM 3705 N N   . VAL C 3 69  ? 214.693 249.566 174.910 1.00 78.94  ? 69  VAL C N   1 
ATOM 3706 C CA  . VAL C 3 69  ? 215.393 249.012 176.058 1.00 73.76  ? 69  VAL C CA  1 
ATOM 3707 C C   . VAL C 3 69  ? 215.469 250.013 177.204 1.00 75.45  ? 69  VAL C C   1 
ATOM 3708 O O   . VAL C 3 69  ? 215.287 249.646 178.365 1.00 83.38  ? 69  VAL C O   1 
ATOM 3709 C CB  . VAL C 3 69  ? 216.799 248.536 175.638 1.00 73.28  ? 69  VAL C CB  1 
ATOM 3710 C CG1 . VAL C 3 69  ? 217.590 248.097 176.847 1.00 72.06  ? 69  VAL C CG1 1 
ATOM 3711 C CG2 . VAL C 3 69  ? 216.693 247.407 174.634 1.00 80.72  ? 69  VAL C CG2 1 
ATOM 3712 N N   . LEU C 3 70  ? 215.738 251.283 176.895 1.00 74.95  ? 70  LEU C N   1 
ATOM 3713 C CA  . LEU C 3 70  ? 215.773 252.306 177.935 1.00 74.09  ? 70  LEU C CA  1 
ATOM 3714 C C   . LEU C 3 70  ? 214.408 252.467 178.587 1.00 72.87  ? 70  LEU C C   1 
ATOM 3715 O O   . LEU C 3 70  ? 214.310 252.703 179.800 1.00 77.75  ? 70  LEU C O   1 
ATOM 3716 C CB  . LEU C 3 70  ? 216.248 253.633 177.349 1.00 74.14  ? 70  LEU C CB  1 
ATOM 3717 C CG  . LEU C 3 70  ? 216.776 254.657 178.351 1.00 67.67  ? 70  LEU C CG  1 
ATOM 3718 C CD1 . LEU C 3 70  ? 217.953 254.084 179.112 1.00 66.30  ? 70  LEU C CD1 1 
ATOM 3719 C CD2 . LEU C 3 70  ? 217.168 255.937 177.645 1.00 72.58  ? 70  LEU C CD2 1 
ATOM 3720 N N   . SER C 3 71  ? 213.341 252.351 177.793 1.00 70.18  ? 71  SER C N   1 
ATOM 3721 C CA  . SER C 3 71  ? 211.998 252.399 178.355 1.00 73.61  ? 71  SER C CA  1 
ATOM 3722 C C   . SER C 3 71  ? 211.824 251.327 179.419 1.00 78.67  ? 71  SER C C   1 
ATOM 3723 O O   . SER C 3 71  ? 211.410 251.619 180.544 1.00 84.04  ? 71  SER C O   1 
ATOM 3724 C CB  . SER C 3 71  ? 210.959 252.228 177.250 1.00 77.00  ? 71  SER C CB  1 
ATOM 3725 O OG  . SER C 3 71  ? 210.686 250.856 177.030 1.00 87.57  ? 71  SER C OG  1 
ATOM 3726 N N   . LYS C 3 72  ? 212.168 250.081 179.084 1.00 77.94  ? 72  LYS C N   1 
ATOM 3727 C CA  . LYS C 3 72  ? 212.041 248.986 180.040 1.00 77.85  ? 72  LYS C CA  1 
ATOM 3728 C C   . LYS C 3 72  ? 212.965 249.168 181.235 1.00 77.07  ? 72  LYS C C   1 
ATOM 3729 O O   . LYS C 3 72  ? 212.632 248.743 182.346 1.00 79.36  ? 72  LYS C O   1 
ATOM 3730 C CB  . LYS C 3 72  ? 212.323 247.653 179.349 1.00 77.43  ? 72  LYS C CB  1 
ATOM 3731 C CG  . LYS C 3 72  ? 211.334 246.555 179.697 1.00 83.05  ? 72  LYS C CG  1 
ATOM 3732 C CD  . LYS C 3 72  ? 210.007 246.765 178.991 1.00 86.79  ? 72  LYS C CD  1 
ATOM 3733 C CE  . LYS C 3 72  ? 209.183 245.489 178.977 1.00 94.10  ? 72  LYS C CE  1 
ATOM 3734 N NZ  . LYS C 3 72  ? 208.653 245.146 180.324 1.00 95.77  ? 72  LYS C NZ  1 
ATOM 3735 N N   . VAL C 3 73  ? 214.129 249.787 181.033 1.00 74.49  ? 73  VAL C N   1 
ATOM 3736 C CA  . VAL C 3 73  ? 215.030 250.035 182.155 1.00 70.67  ? 73  VAL C CA  1 
ATOM 3737 C C   . VAL C 3 73  ? 214.389 250.997 183.150 1.00 78.03  ? 73  VAL C C   1 
ATOM 3738 O O   . VAL C 3 73  ? 214.452 250.789 184.367 1.00 85.00  ? 73  VAL C O   1 
ATOM 3739 C CB  . VAL C 3 73  ? 216.389 250.551 181.646 1.00 70.90  ? 73  VAL C CB  1 
ATOM 3740 C CG1 . VAL C 3 73  ? 217.083 251.369 182.714 1.00 79.31  ? 73  VAL C CG1 1 
ATOM 3741 C CG2 . VAL C 3 73  ? 217.264 249.389 181.220 1.00 69.49  ? 73  VAL C CG2 1 
ATOM 3742 N N   . CYS C 3 74  ? 213.752 252.058 182.651 1.00 76.18  ? 74  CYS C N   1 
ATOM 3743 C CA  . CYS C 3 74  ? 213.030 252.962 183.547 1.00 74.55  ? 74  CYS C CA  1 
ATOM 3744 C C   . CYS C 3 74  ? 211.824 252.273 184.186 1.00 79.15  ? 74  CYS C C   1 
ATOM 3745 O O   . CYS C 3 74  ? 211.505 252.517 185.361 1.00 80.13  ? 74  CYS C O   1 
ATOM 3746 C CB  . CYS C 3 74  ? 212.601 254.215 182.789 1.00 69.51  ? 74  CYS C CB  1 
ATOM 3747 S SG  . CYS C 3 74  ? 213.975 255.218 182.188 1.00 90.28  ? 74  CYS C SG  1 
ATOM 3748 N N   . MET C 3 75  ? 211.134 251.425 183.417 1.00 79.66  ? 75  MET C N   1 
ATOM 3749 C CA  . MET C 3 75  ? 210.059 250.599 183.961 1.00 77.29  ? 75  MET C CA  1 
ATOM 3750 C C   . MET C 3 75  ? 210.545 249.830 185.184 1.00 81.41  ? 75  MET C C   1 
ATOM 3751 O O   . MET C 3 75  ? 209.907 249.841 186.246 1.00 86.98  ? 75  MET C O   1 
ATOM 3752 C CB  . MET C 3 75  ? 209.583 249.616 182.888 1.00 78.88  ? 75  MET C CB  1 
ATOM 3753 C CG  . MET C 3 75  ? 209.073 250.233 181.594 1.00 80.80  ? 75  MET C CG  1 
ATOM 3754 S SD  . MET C 3 75  ? 207.717 249.382 180.770 1.00 88.13  ? 75  MET C SD  1 
ATOM 3755 C CE  . MET C 3 75  ? 206.316 250.123 181.557 1.00 76.35  ? 75  MET C CE  1 
ATOM 3756 N N   . TYR C 3 76  ? 211.693 249.161 185.045 1.00 78.68  ? 76  TYR C N   1 
ATOM 3757 C CA  . TYR C 3 76  ? 212.255 248.383 186.143 1.00 75.93  ? 76  TYR C CA  1 
ATOM 3758 C C   . TYR C 3 76  ? 212.698 249.274 187.291 1.00 75.83  ? 76  TYR C C   1 
ATOM 3759 O O   . TYR C 3 76  ? 212.575 248.889 188.455 1.00 79.22  ? 76  TYR C O   1 
ATOM 3760 C CB  . TYR C 3 76  ? 213.432 247.539 185.661 1.00 73.87  ? 76  TYR C CB  1 
ATOM 3761 C CG  . TYR C 3 76  ? 214.268 246.998 186.801 1.00 74.17  ? 76  TYR C CG  1 
ATOM 3762 C CD1 . TYR C 3 76  ? 213.804 245.959 187.593 1.00 80.57  ? 76  TYR C CD1 1 
ATOM 3763 C CD2 . TYR C 3 76  ? 215.515 247.533 187.091 1.00 77.17  ? 76  TYR C CD2 1 
ATOM 3764 C CE1 . TYR C 3 76  ? 214.556 245.465 188.637 1.00 79.58  ? 76  TYR C CE1 1 
ATOM 3765 C CE2 . TYR C 3 76  ? 216.275 247.044 188.134 1.00 86.26  ? 76  TYR C CE2 1 
ATOM 3766 C CZ  . TYR C 3 76  ? 215.791 246.011 188.902 1.00 83.44  ? 76  TYR C CZ  1 
ATOM 3767 O OH  . TYR C 3 76  ? 216.547 245.524 189.941 1.00 84.68  ? 76  TYR C OH  1 
ATOM 3768 N N   . PHE C 3 77  ? 213.256 250.447 186.989 1.00 75.00  ? 77  PHE C N   1 
ATOM 3769 C CA  . PHE C 3 77  ? 213.610 251.375 188.058 1.00 76.30  ? 77  PHE C CA  1 
ATOM 3770 C C   . PHE C 3 77  ? 212.400 251.664 188.933 1.00 77.31  ? 77  PHE C C   1 
ATOM 3771 O O   . PHE C 3 77  ? 212.451 251.514 190.161 1.00 79.91  ? 77  PHE C O   1 
ATOM 3772 C CB  . PHE C 3 77  ? 214.161 252.676 187.474 1.00 80.81  ? 77  PHE C CB  1 
ATOM 3773 C CG  . PHE C 3 77  ? 215.573 252.575 186.979 1.00 84.73  ? 77  PHE C CG  1 
ATOM 3774 C CD1 . PHE C 3 77  ? 216.399 251.548 187.397 1.00 86.01  ? 77  PHE C CD1 1 
ATOM 3775 C CD2 . PHE C 3 77  ? 216.075 253.513 186.096 1.00 83.62  ? 77  PHE C CD2 1 
ATOM 3776 C CE1 . PHE C 3 77  ? 217.696 251.458 186.941 1.00 91.84  ? 77  PHE C CE1 1 
ATOM 3777 C CE2 . PHE C 3 77  ? 217.370 253.427 185.637 1.00 85.73  ? 77  PHE C CE2 1 
ATOM 3778 C CZ  . PHE C 3 77  ? 218.181 252.399 186.060 1.00 93.24  ? 77  PHE C CZ  1 
ATOM 3779 N N   . THR C 3 78  ? 211.290 252.049 188.303 1.00 76.18  ? 78  THR C N   1 
ATOM 3780 C CA  . THR C 3 78  ? 210.080 252.359 189.058 1.00 77.75  ? 78  THR C CA  1 
ATOM 3781 C C   . THR C 3 78  ? 209.585 251.141 189.828 1.00 78.11  ? 78  THR C C   1 
ATOM 3782 O O   . THR C 3 78  ? 209.240 251.237 191.013 1.00 82.14  ? 78  THR C O   1 
ATOM 3783 C CB  . THR C 3 78  ? 208.992 252.875 188.119 1.00 81.07  ? 78  THR C CB  1 
ATOM 3784 O OG1 . THR C 3 78  ? 209.518 253.936 187.313 1.00 87.43  ? 78  THR C OG1 1 
ATOM 3785 C CG2 . THR C 3 78  ? 207.808 253.392 188.917 1.00 83.83  ? 78  THR C CG2 1 
ATOM 3786 N N   . TYR C 3 79  ? 209.558 249.980 189.171 1.00 77.60  ? 79  TYR C N   1 
ATOM 3787 C CA  . TYR C 3 79  ? 209.024 248.776 189.801 1.00 76.56  ? 79  TYR C CA  1 
ATOM 3788 C C   . TYR C 3 79  ? 209.855 248.372 191.015 1.00 77.71  ? 79  TYR C C   1 
ATOM 3789 O O   . TYR C 3 79  ? 209.312 248.095 192.091 1.00 79.36  ? 79  TYR C O   1 
ATOM 3790 C CB  . TYR C 3 79  ? 208.962 247.653 188.762 1.00 79.95  ? 79  TYR C CB  1 
ATOM 3791 C CG  . TYR C 3 79  ? 208.988 246.238 189.296 1.00 80.65  ? 79  TYR C CG  1 
ATOM 3792 C CD1 . TYR C 3 79  ? 210.188 245.570 189.502 1.00 78.32  ? 79  TYR C CD1 1 
ATOM 3793 C CD2 . TYR C 3 79  ? 207.809 245.555 189.551 1.00 82.77  ? 79  TYR C CD2 1 
ATOM 3794 C CE1 . TYR C 3 79  ? 210.210 244.277 189.975 1.00 78.57  ? 79  TYR C CE1 1 
ATOM 3795 C CE2 . TYR C 3 79  ? 207.823 244.262 190.022 1.00 85.00  ? 79  TYR C CE2 1 
ATOM 3796 C CZ  . TYR C 3 79  ? 209.025 243.628 190.232 1.00 84.32  ? 79  TYR C CZ  1 
ATOM 3797 O OH  . TYR C 3 79  ? 209.040 242.336 190.702 1.00 96.49  ? 79  TYR C OH  1 
ATOM 3798 N N   . LYS C 3 80  ? 211.180 248.349 190.862 1.00 76.04  ? 80  LYS C N   1 
ATOM 3799 C CA  . LYS C 3 80  ? 212.059 247.956 191.956 1.00 74.02  ? 80  LYS C CA  1 
ATOM 3800 C C   . LYS C 3 80  ? 211.997 248.951 193.105 1.00 77.01  ? 80  LYS C C   1 
ATOM 3801 O O   . LYS C 3 80  ? 211.979 248.550 194.274 1.00 82.10  ? 80  LYS C O   1 
ATOM 3802 C CB  . LYS C 3 80  ? 213.493 247.810 191.446 1.00 75.51  ? 80  LYS C CB  1 
ATOM 3803 C CG  . LYS C 3 80  ? 214.565 248.046 192.496 1.00 73.75  ? 80  LYS C CG  1 
ATOM 3804 C CD  . LYS C 3 80  ? 214.747 246.831 193.387 1.00 79.05  ? 80  LYS C CD  1 
ATOM 3805 C CE  . LYS C 3 80  ? 216.185 246.709 193.861 1.00 83.56  ? 80  LYS C CE  1 
ATOM 3806 N NZ  . LYS C 3 80  ? 217.126 246.561 192.718 1.00 87.09  ? 80  LYS C NZ  1 
ATOM 3807 N N   . VAL C 3 81  ? 211.963 250.251 192.802 1.00 77.70  ? 81  VAL C N   1 
ATOM 3808 C CA  . VAL C 3 81  ? 211.878 251.238 193.873 1.00 79.14  ? 81  VAL C CA  1 
ATOM 3809 C C   . VAL C 3 81  ? 210.568 251.083 194.635 1.00 79.66  ? 81  VAL C C   1 
ATOM 3810 O O   . VAL C 3 81  ? 210.541 251.143 195.870 1.00 80.84  ? 81  VAL C O   1 
ATOM 3811 C CB  . VAL C 3 81  ? 212.045 252.661 193.309 1.00 85.45  ? 81  VAL C CB  1 
ATOM 3812 C CG1 . VAL C 3 81  ? 211.350 253.673 194.202 1.00 83.79  ? 81  VAL C CG1 1 
ATOM 3813 C CG2 . VAL C 3 81  ? 213.518 252.997 193.169 1.00 91.38  ? 81  VAL C CG2 1 
ATOM 3814 N N   . ARG C 3 82  ? 209.464 250.868 193.916 1.00 79.88  ? 82  ARG C N   1 
ATOM 3815 C CA  . ARG C 3 82  ? 208.170 250.765 194.580 1.00 81.35  ? 82  ARG C CA  1 
ATOM 3816 C C   . ARG C 3 82  ? 208.064 249.496 195.419 1.00 83.52  ? 82  ARG C C   1 
ATOM 3817 O O   . ARG C 3 82  ? 207.547 249.532 196.541 1.00 86.83  ? 82  ARG C O   1 
ATOM 3818 C CB  . ARG C 3 82  ? 207.047 250.819 193.546 1.00 84.98  ? 82  ARG C CB  1 
ATOM 3819 C CG  . ARG C 3 82  ? 205.811 250.020 193.921 1.00 86.70  ? 82  ARG C CG  1 
ATOM 3820 C CD  . ARG C 3 82  ? 204.914 250.804 194.859 1.00 89.00  ? 82  ARG C CD  1 
ATOM 3821 N NE  . ARG C 3 82  ? 203.548 250.297 194.854 1.00 96.57  ? 82  ARG C NE  1 
ATOM 3822 C CZ  . ARG C 3 82  ? 203.074 249.416 195.724 1.00 94.98  ? 82  ARG C CZ  1 
ATOM 3823 N NH1 . ARG C 3 82  ? 203.833 248.920 196.688 1.00 88.88  ? 82  ARG C NH1 1 
ATOM 3824 N NH2 . ARG C 3 82  ? 201.808 249.022 195.625 1.00 94.95  ? 82  ARG C NH2 1 
ATOM 3825 N N   . TYR C 3 83  ? 208.552 248.368 194.905 1.00 81.86  ? 83  TYR C N   1 
ATOM 3826 C CA  . TYR C 3 83  ? 208.272 247.073 195.510 1.00 82.54  ? 83  TYR C CA  1 
ATOM 3827 C C   . TYR C 3 83  ? 209.408 246.541 196.373 1.00 85.10  ? 83  TYR C C   1 
ATOM 3828 O O   . TYR C 3 83  ? 209.364 245.375 196.776 1.00 87.20  ? 83  TYR C O   1 
ATOM 3829 C CB  . TYR C 3 83  ? 207.927 246.053 194.427 1.00 82.24  ? 83  TYR C CB  1 
ATOM 3830 C CG  . TYR C 3 83  ? 206.503 246.152 193.937 1.00 81.74  ? 83  TYR C CG  1 
ATOM 3831 C CD1 . TYR C 3 83  ? 205.458 246.348 194.824 1.00 81.39  ? 83  TYR C CD1 1 
ATOM 3832 C CD2 . TYR C 3 83  ? 206.206 246.054 192.588 1.00 85.37  ? 83  TYR C CD2 1 
ATOM 3833 C CE1 . TYR C 3 83  ? 204.155 246.440 194.380 1.00 86.05  ? 83  TYR C CE1 1 
ATOM 3834 C CE2 . TYR C 3 83  ? 204.908 246.146 192.135 1.00 86.85  ? 83  TYR C CE2 1 
ATOM 3835 C CZ  . TYR C 3 83  ? 203.887 246.339 193.035 1.00 86.02  ? 83  TYR C CZ  1 
ATOM 3836 O OH  . TYR C 3 83  ? 202.590 246.430 192.586 1.00 84.41  ? 83  TYR C OH  1 
ATOM 3837 N N   . THR C 3 84  ? 210.419 247.351 196.670 1.00 88.28  ? 84  THR C N   1 
ATOM 3838 C CA  . THR C 3 84  ? 211.502 246.893 197.529 1.00 91.04  ? 84  THR C CA  1 
ATOM 3839 C C   . THR C 3 84  ? 211.058 246.887 198.988 1.00 100.51 ? 84  THR C C   1 
ATOM 3840 O O   . THR C 3 84  ? 210.285 247.747 199.422 1.00 100.40 ? 84  THR C O   1 
ATOM 3841 C CB  . THR C 3 84  ? 212.749 247.763 197.348 1.00 90.13  ? 84  THR C CB  1 
ATOM 3842 O OG1 . THR C 3 84  ? 213.877 247.114 197.948 1.00 91.17  ? 84  THR C OG1 1 
ATOM 3843 C CG2 . THR C 3 84  ? 212.566 249.139 197.976 1.00 86.12  ? 84  THR C CG2 1 
ATOM 3844 N N   . ASN C 3 85  ? 211.534 245.888 199.734 1.00 103.52 ? 85  ASN C N   1 
ATOM 3845 C CA  . ASN C 3 85  ? 211.224 245.739 201.157 1.00 104.17 ? 85  ASN C CA  1 
ATOM 3846 C C   . ASN C 3 85  ? 209.717 245.753 201.405 1.00 108.42 ? 85  ASN C C   1 
ATOM 3847 O O   . ASN C 3 85  ? 209.224 246.390 202.338 1.00 107.07 ? 85  ASN C O   1 
ATOM 3848 C CB  . ASN C 3 85  ? 211.921 246.818 201.986 1.00 96.78  ? 85  ASN C CB  1 
ATOM 3849 N N   . SER C 3 86  ? 208.977 245.043 200.559 1.00 110.53 ? 86  SER C N   1 
ATOM 3850 C CA  . SER C 3 86  ? 207.524 244.983 200.639 1.00 116.92 ? 86  SER C CA  1 
ATOM 3851 C C   . SER C 3 86  ? 207.098 243.619 201.161 1.00 125.21 ? 86  SER C C   1 
ATOM 3852 O O   . SER C 3 86  ? 207.606 242.588 200.706 1.00 126.31 ? 86  SER C O   1 
ATOM 3853 C CB  . SER C 3 86  ? 206.887 245.250 199.274 1.00 115.79 ? 86  SER C CB  1 
ATOM 3854 O OG  . SER C 3 86  ? 205.593 244.679 199.198 1.00 119.83 ? 86  SER C OG  1 
ATOM 3855 N N   . SER C 3 87  ? 206.168 243.618 202.118 1.00 128.00 ? 87  SER C N   1 
ATOM 3856 C CA  . SER C 3 87  ? 205.704 242.363 202.700 1.00 129.08 ? 87  SER C CA  1 
ATOM 3857 C C   . SER C 3 87  ? 204.850 241.572 201.717 1.00 127.19 ? 87  SER C C   1 
ATOM 3858 O O   . SER C 3 87  ? 204.970 240.345 201.631 1.00 124.04 ? 87  SER C O   1 
ATOM 3859 C CB  . SER C 3 87  ? 204.923 242.640 203.984 1.00 131.74 ? 87  SER C CB  1 
ATOM 3860 O OG  . SER C 3 87  ? 203.821 243.495 203.732 1.00 132.50 ? 87  SER C OG  1 
ATOM 3861 N N   . THR C 3 88  ? 203.986 242.253 200.968 1.00 128.08 ? 88  THR C N   1 
ATOM 3862 C CA  . THR C 3 88  ? 203.062 241.572 200.076 1.00 129.48 ? 88  THR C CA  1 
ATOM 3863 C C   . THR C 3 88  ? 203.804 240.972 198.882 1.00 129.66 ? 88  THR C C   1 
ATOM 3864 O O   . THR C 3 88  ? 204.996 241.210 198.665 1.00 126.14 ? 88  THR C O   1 
ATOM 3865 C CB  . THR C 3 88  ? 201.975 242.530 199.592 1.00 132.03 ? 88  THR C CB  1 
ATOM 3866 O OG1 . THR C 3 88  ? 200.931 241.786 198.953 1.00 130.68 ? 88  THR C OG1 1 
ATOM 3867 C CG2 . THR C 3 88  ? 202.552 243.532 198.604 1.00 128.06 ? 88  THR C CG2 1 
ATOM 3868 N N   . GLU C 3 89  ? 203.075 240.176 198.104 1.00 130.08 ? 89  GLU C N   1 
ATOM 3869 C CA  . GLU C 3 89  ? 203.658 239.512 196.947 1.00 124.84 ? 89  GLU C CA  1 
ATOM 3870 C C   . GLU C 3 89  ? 204.085 240.528 195.896 1.00 120.88 ? 89  GLU C C   1 
ATOM 3871 O O   . GLU C 3 89  ? 203.419 241.545 195.683 1.00 120.03 ? 89  GLU C O   1 
ATOM 3872 C CB  . GLU C 3 89  ? 202.660 238.523 196.345 1.00 116.01 ? 89  GLU C CB  1 
ATOM 3873 N N   . ILE C 3 90  ? 205.203 240.247 195.240 1.00 116.26 ? 90  ILE C N   1 
ATOM 3874 C CA  . ILE C 3 90  ? 205.758 241.114 194.205 1.00 109.85 ? 90  ILE C CA  1 
ATOM 3875 C C   . ILE C 3 90  ? 205.381 240.533 192.845 1.00 110.18 ? 90  ILE C C   1 
ATOM 3876 O O   . ILE C 3 90  ? 205.757 239.389 192.549 1.00 114.89 ? 90  ILE C O   1 
ATOM 3877 C CB  . ILE C 3 90  ? 207.281 241.260 194.348 1.00 108.14 ? 90  ILE C CB  1 
ATOM 3878 C CG1 . ILE C 3 90  ? 207.947 239.900 194.565 1.00 108.05 ? 90  ILE C CG1 1 
ATOM 3879 C CG2 . ILE C 3 90  ? 207.613 242.188 195.501 1.00 111.49 ? 90  ILE C CG2 1 
ATOM 3880 C CD1 . ILE C 3 90  ? 209.458 239.950 194.553 1.00 104.60 ? 90  ILE C CD1 1 
ATOM 3881 N N   . PRO C 3 91  ? 204.630 241.252 192.016 1.00 108.80 ? 91  PRO C N   1 
ATOM 3882 C CA  . PRO C 3 91  ? 204.290 240.728 190.690 1.00 110.48 ? 91  PRO C CA  1 
ATOM 3883 C C   . PRO C 3 91  ? 205.519 240.608 189.805 1.00 107.63 ? 91  PRO C C   1 
ATOM 3884 O O   . PRO C 3 91  ? 206.495 241.348 189.946 1.00 106.90 ? 91  PRO C O   1 
ATOM 3885 C CB  . PRO C 3 91  ? 203.306 241.766 190.136 1.00 106.37 ? 91  PRO C CB  1 
ATOM 3886 C CG  . PRO C 3 91  ? 202.825 242.527 191.331 1.00 104.61 ? 91  PRO C CG  1 
ATOM 3887 C CD  . PRO C 3 91  ? 203.971 242.538 192.288 1.00 103.39 ? 91  PRO C CD  1 
ATOM 3888 N N   . GLU C 3 92  ? 205.461 239.652 188.882 1.00 103.16 ? 92  GLU C N   1 
ATOM 3889 C CA  . GLU C 3 92  ? 206.583 239.401 187.991 1.00 101.75 ? 92  GLU C CA  1 
ATOM 3890 C C   . GLU C 3 92  ? 206.745 240.536 186.987 1.00 101.96 ? 92  GLU C C   1 
ATOM 3891 O O   . GLU C 3 92  ? 205.788 241.228 186.634 1.00 103.26 ? 92  GLU C O   1 
ATOM 3892 C CB  . GLU C 3 92  ? 206.392 238.077 187.254 1.00 100.64 ? 92  GLU C CB  1 
ATOM 3893 N N   . PHE C 3 93  ? 207.981 240.722 186.527 1.00 100.28 ? 93  PHE C N   1 
ATOM 3894 C CA  . PHE C 3 93  ? 208.286 241.755 185.547 1.00 96.54  ? 93  PHE C CA  1 
ATOM 3895 C C   . PHE C 3 93  ? 208.069 241.208 184.144 1.00 98.37  ? 93  PHE C C   1 
ATOM 3896 O O   . PHE C 3 93  ? 208.762 240.262 183.749 1.00 102.68 ? 93  PHE C O   1 
ATOM 3897 C CB  . PHE C 3 93  ? 209.718 242.232 185.699 1.00 92.90  ? 93  PHE C CB  1 
ATOM 3898 C CG  . PHE C 3 93  ? 209.958 243.608 185.155 1.00 92.28  ? 93  PHE C CG  1 
ATOM 3899 C CD1 . PHE C 3 93  ? 209.140 244.662 185.520 1.00 90.51  ? 93  PHE C CD1 1 
ATOM 3900 C CD2 . PHE C 3 93  ? 211.000 243.848 184.278 1.00 88.16  ? 93  PHE C CD2 1 
ATOM 3901 C CE1 . PHE C 3 93  ? 209.358 245.928 185.022 1.00 82.38  ? 93  PHE C CE1 1 
ATOM 3902 C CE2 . PHE C 3 93  ? 211.221 245.112 183.777 1.00 81.49  ? 93  PHE C CE2 1 
ATOM 3903 C CZ  . PHE C 3 93  ? 210.399 246.153 184.149 1.00 81.26  ? 93  PHE C CZ  1 
ATOM 3904 N N   . PRO C 3 94  ? 207.138 241.758 183.367 1.00 99.51  ? 94  PRO C N   1 
ATOM 3905 C CA  . PRO C 3 94  ? 206.916 241.242 182.010 1.00 101.82 ? 94  PRO C CA  1 
ATOM 3906 C C   . PRO C 3 94  ? 208.045 241.655 181.077 1.00 101.32 ? 94  PRO C C   1 
ATOM 3907 O O   . PRO C 3 94  ? 208.354 242.840 180.938 1.00 100.60 ? 94  PRO C O   1 
ATOM 3908 C CB  . PRO C 3 94  ? 205.583 241.879 181.602 1.00 103.16 ? 94  PRO C CB  1 
ATOM 3909 C CG  . PRO C 3 94  ? 205.503 243.125 182.414 1.00 105.78 ? 94  PRO C CG  1 
ATOM 3910 C CD  . PRO C 3 94  ? 206.209 242.847 183.711 1.00 99.82  ? 94  PRO C CD  1 
ATOM 3911 N N   . ILE C 3 95  ? 208.663 240.664 180.441 1.00 102.37 ? 95  ILE C N   1 
ATOM 3912 C CA  . ILE C 3 95  ? 209.742 240.886 179.486 1.00 102.07 ? 95  ILE C CA  1 
ATOM 3913 C C   . ILE C 3 95  ? 209.389 240.156 178.199 1.00 107.91 ? 95  ILE C C   1 
ATOM 3914 O O   . ILE C 3 95  ? 209.146 238.944 178.218 1.00 109.42 ? 95  ILE C O   1 
ATOM 3915 C CB  . ILE C 3 95  ? 211.098 240.403 180.024 1.00 97.11  ? 95  ILE C CB  1 
ATOM 3916 C CG1 . ILE C 3 95  ? 211.540 241.261 181.207 1.00 99.42  ? 95  ILE C CG1 1 
ATOM 3917 C CG2 . ILE C 3 95  ? 212.145 240.431 178.927 1.00 94.22  ? 95  ILE C CG2 1 
ATOM 3918 C CD1 . ILE C 3 95  ? 212.922 240.927 181.715 1.00 91.61  ? 95  ILE C CD1 1 
ATOM 3919 N N   . ALA C 3 96  ? 209.355 240.885 177.091 1.00 108.44 ? 96  ALA C N   1 
ATOM 3920 C CA  . ALA C 3 96  ? 209.150 240.246 175.802 1.00 108.43 ? 96  ALA C CA  1 
ATOM 3921 C C   . ALA C 3 96  ? 210.397 239.455 175.413 1.00 105.79 ? 96  ALA C C   1 
ATOM 3922 O O   . ALA C 3 96  ? 211.519 239.904 175.663 1.00 107.57 ? 96  ALA C O   1 
ATOM 3923 C CB  . ALA C 3 96  ? 208.828 241.285 174.730 1.00 107.99 ? 96  ALA C CB  1 
ATOM 3924 N N   . PRO C 3 97  ? 210.235 238.273 174.816 1.00 103.48 ? 97  PRO C N   1 
ATOM 3925 C CA  . PRO C 3 97  ? 211.415 237.473 174.448 1.00 99.85  ? 97  PRO C CA  1 
ATOM 3926 C C   . PRO C 3 97  ? 212.349 238.166 173.473 1.00 101.58 ? 97  PRO C C   1 
ATOM 3927 O O   . PRO C 3 97  ? 213.563 237.932 173.524 1.00 100.94 ? 97  PRO C O   1 
ATOM 3928 C CB  . PRO C 3 97  ? 210.800 236.208 173.833 1.00 103.81 ? 97  PRO C CB  1 
ATOM 3929 C CG  . PRO C 3 97  ? 209.423 236.138 174.397 1.00 105.27 ? 97  PRO C CG  1 
ATOM 3930 C CD  . PRO C 3 97  ? 208.974 237.555 174.569 1.00 107.03 ? 97  PRO C CD  1 
ATOM 3931 N N   . GLU C 3 98  ? 211.823 239.007 172.579 1.00 105.44 ? 98  GLU C N   1 
ATOM 3932 C CA  . GLU C 3 98  ? 212.667 239.638 171.568 1.00 105.39 ? 98  GLU C CA  1 
ATOM 3933 C C   . GLU C 3 98  ? 213.688 240.579 172.195 1.00 104.82 ? 98  GLU C C   1 
ATOM 3934 O O   . GLU C 3 98  ? 214.857 240.595 171.792 1.00 104.22 ? 98  GLU C O   1 
ATOM 3935 C CB  . GLU C 3 98  ? 211.808 240.393 170.550 1.00 103.93 ? 98  GLU C CB  1 
ATOM 3936 C CG  . GLU C 3 98  ? 210.768 239.552 169.816 1.00 111.23 ? 98  GLU C CG  1 
ATOM 3937 C CD  . GLU C 3 98  ? 209.547 239.239 170.658 1.00 117.08 ? 98  GLU C CD  1 
ATOM 3938 O OE1 . GLU C 3 98  ? 209.646 238.371 171.550 1.00 113.80 ? 98  GLU C OE1 1 
ATOM 3939 O OE2 . GLU C 3 98  ? 208.489 239.863 170.430 1.00 122.97 ? 98  GLU C OE2 1 
ATOM 3940 N N   . ILE C 3 99  ? 213.270 241.368 173.183 1.00 103.67 ? 99  ILE C N   1 
ATOM 3941 C CA  . ILE C 3 99  ? 214.124 242.402 173.758 1.00 96.84  ? 99  ILE C CA  1 
ATOM 3942 C C   . ILE C 3 99  ? 214.914 241.841 174.932 1.00 94.24  ? 99  ILE C C   1 
ATOM 3943 O O   . ILE C 3 99  ? 215.631 242.578 175.618 1.00 93.58  ? 99  ILE C O   1 
ATOM 3944 C CB  . ILE C 3 99  ? 213.295 243.624 174.190 1.00 92.34  ? 99  ILE C CB  1 
ATOM 3945 C CG1 . ILE C 3 99  ? 212.593 243.349 175.520 1.00 89.52  ? 99  ILE C CG1 1 
ATOM 3946 C CG2 . ILE C 3 99  ? 212.274 243.973 173.124 1.00 95.69  ? 99  ILE C CG2 1 
ATOM 3947 C CD1 . ILE C 3 99  ? 212.310 244.592 176.326 1.00 88.70  ? 99  ILE C CD1 1 
ATOM 3948 N N   . ALA C 3 100 ? 214.798 240.531 175.164 1.00 94.86  ? 100 ALA C N   1 
ATOM 3949 C CA  . ALA C 3 100 ? 215.432 239.927 176.332 1.00 90.97  ? 100 ALA C CA  1 
ATOM 3950 C C   . ALA C 3 100 ? 216.946 240.090 176.298 1.00 92.00  ? 100 ALA C C   1 
ATOM 3951 O O   . ALA C 3 100 ? 217.559 240.454 177.307 1.00 93.33  ? 100 ALA C O   1 
ATOM 3952 C CB  . ALA C 3 100 ? 215.057 238.449 176.423 1.00 90.09  ? 100 ALA C CB  1 
ATOM 3953 N N   . LEU C 3 101 ? 217.567 239.838 175.144 1.00 88.78  ? 101 LEU C N   1 
ATOM 3954 C CA  . LEU C 3 101 ? 219.024 239.893 175.065 1.00 86.40  ? 101 LEU C CA  1 
ATOM 3955 C C   . LEU C 3 101 ? 219.534 241.317 175.249 1.00 89.30  ? 101 LEU C C   1 
ATOM 3956 O O   . LEU C 3 101 ? 220.472 241.557 176.018 1.00 90.72  ? 101 LEU C O   1 
ATOM 3957 C CB  . LEU C 3 101 ? 219.500 239.319 173.731 1.00 83.08  ? 101 LEU C CB  1 
ATOM 3958 C CG  . LEU C 3 101 ? 220.898 238.698 173.745 1.00 83.75  ? 101 LEU C CG  1 
ATOM 3959 C CD1 . LEU C 3 101 ? 220.827 237.251 174.201 1.00 85.34  ? 101 LEU C CD1 1 
ATOM 3960 C CD2 . LEU C 3 101 ? 221.566 238.803 172.382 1.00 84.04  ? 101 LEU C CD2 1 
ATOM 3961 N N   . GLU C 3 102 ? 218.930 242.279 174.550 1.00 88.67  ? 102 GLU C N   1 
ATOM 3962 C CA  . GLU C 3 102 ? 219.384 243.660 174.663 1.00 87.84  ? 102 GLU C CA  1 
ATOM 3963 C C   . GLU C 3 102 ? 219.116 244.218 176.056 1.00 86.45  ? 102 GLU C C   1 
ATOM 3964 O O   . GLU C 3 102 ? 219.930 244.980 176.593 1.00 92.12  ? 102 GLU C O   1 
ATOM 3965 C CB  . GLU C 3 102 ? 218.718 244.522 173.593 1.00 92.13  ? 102 GLU C CB  1 
ATOM 3966 C CG  . GLU C 3 102 ? 219.179 244.209 172.178 1.00 102.44 ? 102 GLU C CG  1 
ATOM 3967 C CD  . GLU C 3 102 ? 218.607 245.166 171.149 1.00 108.95 ? 102 GLU C CD  1 
ATOM 3968 O OE1 . GLU C 3 102 ? 219.282 245.411 170.127 1.00 109.24 ? 102 GLU C OE1 1 
ATOM 3969 O OE2 . GLU C 3 102 ? 217.486 245.674 171.361 1.00 109.59 ? 102 GLU C OE2 1 
ATOM 3970 N N   . LEU C 3 103 ? 217.980 243.855 176.655 1.00 82.47  ? 103 LEU C N   1 
ATOM 3971 C CA  . LEU C 3 103 ? 217.699 244.292 178.018 1.00 78.67  ? 103 LEU C CA  1 
ATOM 3972 C C   . LEU C 3 103 ? 218.710 243.694 178.987 1.00 82.19  ? 103 LEU C C   1 
ATOM 3973 O O   . LEU C 3 103 ? 219.146 244.359 179.933 1.00 85.04  ? 103 LEU C O   1 
ATOM 3974 C CB  . LEU C 3 103 ? 216.272 243.904 178.406 1.00 78.22  ? 103 LEU C CB  1 
ATOM 3975 C CG  . LEU C 3 103 ? 215.784 244.078 179.845 1.00 78.37  ? 103 LEU C CG  1 
ATOM 3976 C CD1 . LEU C 3 103 ? 216.226 245.410 180.424 1.00 73.84  ? 103 LEU C CD1 1 
ATOM 3977 C CD2 . LEU C 3 103 ? 214.273 243.943 179.907 1.00 87.40  ? 103 LEU C CD2 1 
ATOM 3978 N N   . LEU C 3 104 ? 219.099 242.439 178.760 1.00 84.32  ? 104 LEU C N   1 
ATOM 3979 C CA  . LEU C 3 104 ? 220.154 241.826 179.558 1.00 86.41  ? 104 LEU C CA  1 
ATOM 3980 C C   . LEU C 3 104 ? 221.466 242.586 179.412 1.00 88.03  ? 104 LEU C C   1 
ATOM 3981 O O   . LEU C 3 104 ? 222.175 242.815 180.399 1.00 87.25  ? 104 LEU C O   1 
ATOM 3982 C CB  . LEU C 3 104 ? 220.325 240.366 179.141 1.00 82.37  ? 104 LEU C CB  1 
ATOM 3983 C CG  . LEU C 3 104 ? 221.633 239.664 179.490 1.00 83.24  ? 104 LEU C CG  1 
ATOM 3984 C CD1 . LEU C 3 104 ? 221.761 239.520 180.986 1.00 89.25  ? 104 LEU C CD1 1 
ATOM 3985 C CD2 . LEU C 3 104 ? 221.695 238.310 178.815 1.00 82.18  ? 104 LEU C CD2 1 
ATOM 3986 N N   . MET C 3 105 ? 221.805 242.982 178.183 1.00 87.44  ? 105 MET C N   1 
ATOM 3987 C CA  . MET C 3 105 ? 223.039 243.730 177.959 1.00 86.18  ? 105 MET C CA  1 
ATOM 3988 C C   . MET C 3 105 ? 223.011 245.062 178.694 1.00 86.69  ? 105 MET C C   1 
ATOM 3989 O O   . MET C 3 105 ? 223.997 245.457 179.328 1.00 89.22  ? 105 MET C O   1 
ATOM 3990 C CB  . MET C 3 105 ? 223.247 243.964 176.464 1.00 86.44  ? 105 MET C CB  1 
ATOM 3991 C CG  . MET C 3 105 ? 223.311 242.698 175.648 1.00 93.65  ? 105 MET C CG  1 
ATOM 3992 S SD  . MET C 3 105 ? 224.335 241.416 176.380 1.00 114.28 ? 105 MET C SD  1 
ATOM 3993 C CE  . MET C 3 105 ? 224.579 240.382 174.945 1.00 98.36  ? 105 MET C CE  1 
ATOM 3994 N N   . ALA C 3 106 ? 221.884 245.771 178.614 1.00 85.33  ? 106 ALA C N   1 
ATOM 3995 C CA  . ALA C 3 106 ? 221.762 247.054 179.296 1.00 81.33  ? 106 ALA C CA  1 
ATOM 3996 C C   . ALA C 3 106 ? 221.831 246.885 180.807 1.00 86.79  ? 106 ALA C C   1 
ATOM 3997 O O   . ALA C 3 106 ? 222.458 247.693 181.501 1.00 95.92  ? 106 ALA C O   1 
ATOM 3998 C CB  . ALA C 3 106 ? 220.461 247.743 178.895 1.00 77.40  ? 106 ALA C CB  1 
ATOM 3999 N N   . ALA C 3 107 ? 221.186 245.843 181.337 1.00 83.38  ? 107 ALA C N   1 
ATOM 4000 C CA  . ALA C 3 107 ? 221.251 245.586 182.771 1.00 85.80  ? 107 ALA C CA  1 
ATOM 4001 C C   . ALA C 3 107 ? 222.676 245.279 183.206 1.00 88.44  ? 107 ALA C C   1 
ATOM 4002 O O   . ALA C 3 107 ? 223.110 245.704 184.283 1.00 91.59  ? 107 ALA C O   1 
ATOM 4003 C CB  . ALA C 3 107 ? 220.316 244.437 183.140 1.00 83.96  ? 107 ALA C CB  1 
ATOM 4004 N N   . ASN C 3 108 ? 223.416 244.534 182.385 1.00 86.72  ? 108 ASN C N   1 
ATOM 4005 C CA  . ASN C 3 108 ? 224.820 244.280 182.687 1.00 89.46  ? 108 ASN C CA  1 
ATOM 4006 C C   . ASN C 3 108 ? 225.625 245.573 182.683 1.00 90.05  ? 108 ASN C C   1 
ATOM 4007 O O   . ASN C 3 108 ? 226.479 245.784 183.551 1.00 88.12  ? 108 ASN C O   1 
ATOM 4008 C CB  . ASN C 3 108 ? 225.398 243.285 181.683 1.00 90.11  ? 108 ASN C CB  1 
ATOM 4009 C CG  . ASN C 3 108 ? 226.869 243.017 181.913 1.00 90.22  ? 108 ASN C CG  1 
ATOM 4010 O OD1 . ASN C 3 108 ? 227.682 243.128 180.997 1.00 88.43  ? 108 ASN C OD1 1 
ATOM 4011 N ND2 . ASN C 3 108 ? 227.220 242.660 183.141 1.00 90.03  ? 108 ASN C ND2 1 
ATOM 4012 N N   . PHE C 3 109 ? 225.367 246.451 181.711 1.00 90.22  ? 109 PHE C N   1 
ATOM 4013 C CA  . PHE C 3 109 ? 226.126 247.695 181.626 1.00 86.93  ? 109 PHE C CA  1 
ATOM 4014 C C   . PHE C 3 109 ? 225.732 248.672 182.727 1.00 90.63  ? 109 PHE C C   1 
ATOM 4015 O O   . PHE C 3 109 ? 226.601 249.279 183.363 1.00 93.58  ? 109 PHE C O   1 
ATOM 4016 C CB  . PHE C 3 109 ? 225.932 248.337 180.255 1.00 84.66  ? 109 PHE C CB  1 
ATOM 4017 C CG  . PHE C 3 109 ? 226.299 249.793 180.212 1.00 89.43  ? 109 PHE C CG  1 
ATOM 4018 C CD1 . PHE C 3 109 ? 227.623 250.189 180.269 1.00 91.89  ? 109 PHE C CD1 1 
ATOM 4019 C CD2 . PHE C 3 109 ? 225.320 250.765 180.111 1.00 90.34  ? 109 PHE C CD2 1 
ATOM 4020 C CE1 . PHE C 3 109 ? 227.962 251.526 180.228 1.00 88.01  ? 109 PHE C CE1 1 
ATOM 4021 C CE2 . PHE C 3 109 ? 225.655 252.103 180.070 1.00 90.55  ? 109 PHE C CE2 1 
ATOM 4022 C CZ  . PHE C 3 109 ? 226.977 252.483 180.129 1.00 88.52  ? 109 PHE C CZ  1 
ATOM 4023 N N   . LEU C 3 110 ? 224.432 248.838 182.968 1.00 92.53  ? 110 LEU C N   1 
ATOM 4024 C CA  . LEU C 3 110 ? 223.958 249.841 183.913 1.00 94.54  ? 110 LEU C CA  1 
ATOM 4025 C C   . LEU C 3 110 ? 224.136 249.429 185.367 1.00 102.05 ? 110 LEU C C   1 
ATOM 4026 O O   . LEU C 3 110 ? 224.008 250.286 186.248 1.00 106.95 ? 110 LEU C O   1 
ATOM 4027 C CB  . LEU C 3 110 ? 222.484 250.154 183.652 1.00 90.82  ? 110 LEU C CB  1 
ATOM 4028 C CG  . LEU C 3 110 ? 222.190 251.024 182.431 1.00 88.79  ? 110 LEU C CG  1 
ATOM 4029 C CD1 . LEU C 3 110 ? 220.714 250.967 182.081 1.00 87.91  ? 110 LEU C CD1 1 
ATOM 4030 C CD2 . LEU C 3 110 ? 222.631 252.456 182.671 1.00 88.45  ? 110 LEU C CD2 1 
ATOM 4031 N N   . ASP C 3 111 ? 224.434 248.156 185.635 1.00 103.11 ? 111 ASP C N   1 
ATOM 4032 C CA  . ASP C 3 111 ? 224.599 247.633 186.990 1.00 104.63 ? 111 ASP C CA  1 
ATOM 4033 C C   . ASP C 3 111 ? 223.304 247.885 187.772 1.00 105.93 ? 111 ASP C C   1 
ATOM 4034 O O   . ASP C 3 111 ? 223.192 248.786 188.606 1.00 109.18 ? 111 ASP C O   1 
ATOM 4035 C CB  . ASP C 3 111 ? 225.853 248.248 187.644 1.00 106.33 ? 111 ASP C CB  1 
ATOM 4036 C CG  . ASP C 3 111 ? 225.951 248.035 189.170 1.00 114.37 ? 111 ASP C CG  1 
ATOM 4037 O OD1 . ASP C 3 111 ? 224.990 247.644 189.861 1.00 115.86 ? 111 ASP C OD1 1 
ATOM 4038 O OD2 . ASP C 3 111 ? 227.057 248.275 189.697 1.00 116.44 ? 111 ASP C OD2 1 
ATOM 4039 N N   . CYS C 3 112 ? 222.284 247.132 187.379 1.00 106.92 ? 112 CYS C N   1 
ATOM 4040 C CA  . CYS C 3 112 ? 220.967 247.251 187.990 1.00 110.48 ? 112 CYS C CA  1 
ATOM 4041 C C   . CYS C 3 112 ? 220.240 245.910 187.990 1.00 114.64 ? 112 CYS C C   1 
ATOM 4042 O O   . CYS C 3 112 ? 220.661 244.964 187.327 1.00 116.33 ? 112 CYS C O   1 
ATOM 4043 C CB  . CYS C 3 112 ? 220.132 248.301 187.257 1.00 103.65 ? 112 CYS C CB  1 
ATOM 4044 S SG  . CYS C 3 112 ? 220.079 248.085 185.464 1.00 110.72 ? 112 CYS C SG  1 
ATOM 4045 O OXT . CYS C 3 112 ? 219.214 245.740 188.648 1.00 108.54 ? 112 CYS C OXT 1 
ATOM 4046 N N   . LEU D 4 73  ? 218.158 211.731 220.257 1.00 69.00  ? 73  LEU D N   1 
ATOM 4047 C CA  . LEU D 4 73  ? 219.079 212.708 219.690 1.00 65.10  ? 73  LEU D CA  1 
ATOM 4048 C C   . LEU D 4 73  ? 219.384 212.388 218.234 1.00 63.90  ? 73  LEU D C   1 
ATOM 4049 O O   . LEU D 4 73  ? 220.537 212.173 217.865 1.00 60.71  ? 73  LEU D O   1 
ATOM 4050 C CB  . LEU D 4 73  ? 220.373 212.756 220.500 1.00 68.62  ? 73  LEU D CB  1 
ATOM 4051 C CG  . LEU D 4 73  ? 220.872 214.158 220.846 1.00 76.16  ? 73  LEU D CG  1 
ATOM 4052 C CD1 . LEU D 4 73  ? 219.743 214.999 221.410 1.00 73.23  ? 73  LEU D CD1 1 
ATOM 4053 C CD2 . LEU D 4 73  ? 222.026 214.083 221.828 1.00 81.73  ? 73  LEU D CD2 1 
ATOM 4054 N N   . ARG D 4 74  ? 218.339 212.357 217.412 1.00 66.38  ? 74  ARG D N   1 
ATOM 4055 C CA  . ARG D 4 74  ? 218.500 212.017 216.007 1.00 58.91  ? 74  ARG D CA  1 
ATOM 4056 C C   . ARG D 4 74  ? 219.248 213.116 215.266 1.00 55.46  ? 74  ARG D C   1 
ATOM 4057 O O   . ARG D 4 74  ? 219.014 214.308 215.483 1.00 58.92  ? 74  ARG D O   1 
ATOM 4058 C CB  . ARG D 4 74  ? 217.136 211.784 215.360 1.00 53.98  ? 74  ARG D CB  1 
ATOM 4059 C CG  . ARG D 4 74  ? 216.048 212.706 215.874 1.00 53.89  ? 74  ARG D CG  1 
ATOM 4060 C CD  . ARG D 4 74  ? 214.672 212.108 215.646 1.00 45.50  ? 74  ARG D CD  1 
ATOM 4061 N NE  . ARG D 4 74  ? 214.099 212.533 214.375 1.00 39.50  ? 74  ARG D NE  1 
ATOM 4062 C CZ  . ARG D 4 74  ? 212.804 212.719 214.164 1.00 42.73  ? 74  ARG D CZ  1 
ATOM 4063 N NH1 . ARG D 4 74  ? 211.912 212.528 215.123 1.00 44.81  ? 74  ARG D NH1 1 
ATOM 4064 N NH2 . ARG D 4 74  ? 212.392 213.109 212.961 1.00 43.61  ? 74  ARG D NH2 1 
ATOM 4065 N N   . GLY D 4 75  ? 220.156 212.707 214.386 1.00 52.02  ? 75  GLY D N   1 
ATOM 4066 C CA  . GLY D 4 75  ? 220.893 213.647 213.568 1.00 56.41  ? 75  GLY D CA  1 
ATOM 4067 C C   . GLY D 4 75  ? 220.309 213.777 212.179 1.00 58.95  ? 75  GLY D C   1 
ATOM 4068 O O   . GLY D 4 75  ? 220.731 214.631 211.394 1.00 58.82  ? 75  GLY D O   1 
ATOM 4069 N N   . GLY D 4 76  ? 219.333 212.932 211.866 1.00 57.61  ? 76  GLY D N   1 
ATOM 4070 C CA  . GLY D 4 76  ? 218.680 212.964 210.572 1.00 52.96  ? 76  GLY D CA  1 
ATOM 4071 C C   . GLY D 4 76  ? 217.256 213.475 210.647 1.00 50.54  ? 76  GLY D C   1 
ATOM 4072 O O   . GLY D 4 76  ? 216.366 212.989 209.951 1.00 50.29  ? 76  GLY D O   1 
ATOM 4073 O OXT . GLY D 4 76  ? 216.953 214.386 211.414 1.00 44.19  ? 76  GLY D OXT 1 
# 
