data_9D61
# 
_entry.id   9D61 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9D61         pdb_00009d61 10.2210/pdb9d61/pdb 
WWPDB D_1000287024 ?            ?                   
EMDB  EMD-46585    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-15 ? 
2 'EM metadata'     1 0 2025-01-15 ? 
3 Image             1 0 2025-01-15 ? 
4 'Primary map'     1 0 2025-01-15 ? 
5 'Structure model' 1 1 2025-01-22 ? 
6 Image             1 0 2025-01-15 ? 
7 'Primary map'     1 0 2025-01-15 ? 
8 'Structure model' 1 2 2025-05-21 ? 
9 'EM metadata'     1 1 2025-05-21 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 Image             repository 'Initial release' ? ? 
4 4 'Primary map'     repository 'Initial release' ? ? 
5 6 Image             repository 'Initial release' ? ? 
6 7 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 5 'Structure model' 'Data collection'      
2 5 'Structure model' 'Database references'  
3 8 'Structure model' 'Data collection'      
4 9 'EM metadata'     'Data processing'      
5 9 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 5 'Structure model' citation        
2 5 'Structure model' citation_author 
3 5 'Structure model' em_admin        
4 8 'Structure model' em_admin        
5 8 'Structure model' em_software     
6 9 'EM metadata'     em_admin        
7 9 'EM metadata'     em_software     
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 5 'Structure model' '_citation.pdbx_database_id_PubMed' 
2 5 'Structure model' '_citation.title'                   
3 5 'Structure model' '_citation_author.name'             
4 5 'Structure model' '_em_admin.last_update'             
5 8 'Structure model' '_em_admin.last_update'             
6 8 'Structure model' '_em_software.name'                 
7 9 'EM metadata'     '_em_admin.last_update'             
8 9 'EM metadata'     '_em_software.name'                 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9D61 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-14 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
EMDB 'Focused map receptor'                                                                                                        
EMD-46583 'focused EM volume'    
EMDB 'Focused map G protein'                                                                                                       
EMD-46584 'focused EM volume'    
EMDB 'Composite map, receptor+G protein, Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic , no scFv16,' 
EMD-46585 'associated EM volume' 
EMDB 'Consensus map'                                                                                                               
EMD-46608 'consensus EM volume'  
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gati@usc.edu 
_pdbx_contact_author.name_first         Cornelius 
_pdbx_contact_author.name_last          Gati 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3693-7009 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Gati, C.'           1 0000-0003-3693-7009 
'Motiwala, Z.'       2 0000-0002-8751-8608 
'Tyson, A.S.'        3 0000-0001-6594-7148 
'Styrpejko, D.'      4 0000-0002-7958-6192 
'Han, G.W.'          5 0000-0003-4107-835X 
'Khan, S.'           6 0000-0002-3604-2670 
'Ramos-Gonzalez, N.' 7 0000-0002-9398-8956 
'Shenvi, R.'         8 0000-0001-8353-6449 
'Majumdar, S.'       9 0000-0002-2931-3823 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nat.Chem.Biol. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1552-4469 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Molecular mechanisms of inverse agonism via kappa-opioid receptor-G protein complexes.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41589-024-01812-0 
_citation.pdbx_database_id_PubMed   39775170 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tyson, A.S.'        1  ? 
primary 'Khan, S.'           2  ? 
primary 'Motiwala, Z.'       3  ? 
primary 'Han, G.W.'          4  ? 
primary 'Zhang, Z.'          5  ? 
primary 'Ranjbar, M.'        6  ? 
primary 'Styrpejko, D.'      7  ? 
primary 'Ramos-Gonzalez, N.' 8  ? 
primary 'Woo, S.'            9  ? 
primary 'Villers, K.'        10 ? 
primary 'Landaker, D.'       11 ? 
primary 'Kenakin, T.'        12 ? 
primary 'Shenvi, R.'         13 ? 
primary 'Majumdar, S.'       14 ? 
primary 'Gati, C.'           15 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Kappa-type opioid receptor' 42681.020 1 ? ? ? ? 
2 polymer     man 'Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1' 37416.930 1 ? ? ? ? 
3 polymer     man 'Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2' 7861.143  1 ? ? ? ? 
4 polymer     man 'Guanine nucleotide-binding protein G(i) subunit alpha-1' 40415.031 1 ? ? ? ? 
5 non-polymer syn 
;(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
;
465.628   1 ? ? ? ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
1 K-OR-1,KOR-1                                   
2 'Transducin beta chain 1'                      
3 'G gamma-I'                                    
4 'Adenylate cyclase-inhibiting G alpha protein' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLV
MFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAV
CHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGY
TNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
;
;MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLV
MFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAV
CHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGY
TNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
;
A ? 
2 'polypeptide(L)' no no 
;MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI
IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS
SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV
TDDGMAVATGSWDSFLKIWN
;
;MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI
IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS
SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV
TDDGMAVATGSWDSFLKIWN
;
C ? 
3 'polypeptide(L)' no no MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL 
MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL D ? 
4 'polypeptide(L)' no no 
;MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQS
IIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD
RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY
THFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
;
;MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQS
IIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD
RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY
THFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
;
B ? 
# 
_pdbx_entity_nonpoly.entity_id   5 
_pdbx_entity_nonpoly.name        
;(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
;
_pdbx_entity_nonpoly.comp_id     JDC 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ASP n 
1 3   SER n 
1 4   PRO n 
1 5   ILE n 
1 6   GLN n 
1 7   ILE n 
1 8   PHE n 
1 9   ARG n 
1 10  GLY n 
1 11  GLU n 
1 12  PRO n 
1 13  GLY n 
1 14  PRO n 
1 15  THR n 
1 16  CYS n 
1 17  ALA n 
1 18  PRO n 
1 19  SER n 
1 20  ALA n 
1 21  CYS n 
1 22  LEU n 
1 23  PRO n 
1 24  PRO n 
1 25  ASN n 
1 26  SER n 
1 27  SER n 
1 28  ALA n 
1 29  TRP n 
1 30  PHE n 
1 31  PRO n 
1 32  GLY n 
1 33  TRP n 
1 34  ALA n 
1 35  GLU n 
1 36  PRO n 
1 37  ASP n 
1 38  SER n 
1 39  ASN n 
1 40  GLY n 
1 41  SER n 
1 42  ALA n 
1 43  GLY n 
1 44  SER n 
1 45  GLU n 
1 46  ASP n 
1 47  ALA n 
1 48  GLN n 
1 49  LEU n 
1 50  GLU n 
1 51  PRO n 
1 52  ALA n 
1 53  HIS n 
1 54  ILE n 
1 55  SER n 
1 56  PRO n 
1 57  ALA n 
1 58  ILE n 
1 59  PRO n 
1 60  VAL n 
1 61  ILE n 
1 62  ILE n 
1 63  THR n 
1 64  ALA n 
1 65  VAL n 
1 66  TYR n 
1 67  SER n 
1 68  VAL n 
1 69  VAL n 
1 70  PHE n 
1 71  VAL n 
1 72  VAL n 
1 73  GLY n 
1 74  LEU n 
1 75  VAL n 
1 76  GLY n 
1 77  ASN n 
1 78  SER n 
1 79  LEU n 
1 80  VAL n 
1 81  MET n 
1 82  PHE n 
1 83  VAL n 
1 84  ILE n 
1 85  ILE n 
1 86  ARG n 
1 87  TYR n 
1 88  THR n 
1 89  LYS n 
1 90  MET n 
1 91  LYS n 
1 92  THR n 
1 93  ALA n 
1 94  THR n 
1 95  ASN n 
1 96  ILE n 
1 97  TYR n 
1 98  ILE n 
1 99  PHE n 
1 100 ASN n 
1 101 LEU n 
1 102 ALA n 
1 103 LEU n 
1 104 ALA n 
1 105 ASP n 
1 106 ALA n 
1 107 LEU n 
1 108 VAL n 
1 109 THR n 
1 110 THR n 
1 111 THR n 
1 112 MET n 
1 113 PRO n 
1 114 PHE n 
1 115 GLN n 
1 116 SER n 
1 117 THR n 
1 118 VAL n 
1 119 TYR n 
1 120 LEU n 
1 121 MET n 
1 122 ASN n 
1 123 SER n 
1 124 TRP n 
1 125 PRO n 
1 126 PHE n 
1 127 GLY n 
1 128 ASP n 
1 129 VAL n 
1 130 LEU n 
1 131 CYS n 
1 132 LYS n 
1 133 ILE n 
1 134 VAL n 
1 135 ILE n 
1 136 SER n 
1 137 ILE n 
1 138 ASP n 
1 139 TYR n 
1 140 TYR n 
1 141 ASN n 
1 142 MET n 
1 143 PHE n 
1 144 THR n 
1 145 SER n 
1 146 ILE n 
1 147 PHE n 
1 148 THR n 
1 149 LEU n 
1 150 THR n 
1 151 MET n 
1 152 MET n 
1 153 SER n 
1 154 VAL n 
1 155 ASP n 
1 156 ARG n 
1 157 TYR n 
1 158 ILE n 
1 159 ALA n 
1 160 VAL n 
1 161 CYS n 
1 162 HIS n 
1 163 PRO n 
1 164 VAL n 
1 165 LYS n 
1 166 ALA n 
1 167 LEU n 
1 168 ASP n 
1 169 PHE n 
1 170 ARG n 
1 171 THR n 
1 172 PRO n 
1 173 LEU n 
1 174 LYS n 
1 175 ALA n 
1 176 LYS n 
1 177 ILE n 
1 178 ILE n 
1 179 ASN n 
1 180 ILE n 
1 181 CYS n 
1 182 ILE n 
1 183 TRP n 
1 184 LEU n 
1 185 LEU n 
1 186 SER n 
1 187 SER n 
1 188 SER n 
1 189 VAL n 
1 190 GLY n 
1 191 ILE n 
1 192 SER n 
1 193 ALA n 
1 194 ILE n 
1 195 VAL n 
1 196 LEU n 
1 197 GLY n 
1 198 GLY n 
1 199 THR n 
1 200 LYS n 
1 201 VAL n 
1 202 ARG n 
1 203 GLU n 
1 204 ASP n 
1 205 VAL n 
1 206 ASP n 
1 207 VAL n 
1 208 ILE n 
1 209 GLU n 
1 210 CYS n 
1 211 SER n 
1 212 LEU n 
1 213 GLN n 
1 214 PHE n 
1 215 PRO n 
1 216 ASP n 
1 217 ASP n 
1 218 ASP n 
1 219 TYR n 
1 220 SER n 
1 221 TRP n 
1 222 TRP n 
1 223 ASP n 
1 224 LEU n 
1 225 PHE n 
1 226 MET n 
1 227 LYS n 
1 228 ILE n 
1 229 CYS n 
1 230 VAL n 
1 231 PHE n 
1 232 ILE n 
1 233 PHE n 
1 234 ALA n 
1 235 PHE n 
1 236 VAL n 
1 237 ILE n 
1 238 PRO n 
1 239 VAL n 
1 240 LEU n 
1 241 ILE n 
1 242 ILE n 
1 243 ILE n 
1 244 VAL n 
1 245 CYS n 
1 246 TYR n 
1 247 THR n 
1 248 LEU n 
1 249 MET n 
1 250 ILE n 
1 251 LEU n 
1 252 ARG n 
1 253 LEU n 
1 254 LYS n 
1 255 SER n 
1 256 VAL n 
1 257 ARG n 
1 258 LEU n 
1 259 LEU n 
1 260 SER n 
1 261 GLY n 
1 262 SER n 
1 263 ARG n 
1 264 GLU n 
1 265 LYS n 
1 266 ASP n 
1 267 ARG n 
1 268 ASN n 
1 269 LEU n 
1 270 ARG n 
1 271 ARG n 
1 272 ILE n 
1 273 THR n 
1 274 ARG n 
1 275 LEU n 
1 276 VAL n 
1 277 LEU n 
1 278 VAL n 
1 279 VAL n 
1 280 VAL n 
1 281 ALA n 
1 282 VAL n 
1 283 PHE n 
1 284 VAL n 
1 285 VAL n 
1 286 CYS n 
1 287 TRP n 
1 288 THR n 
1 289 PRO n 
1 290 ILE n 
1 291 HIS n 
1 292 ILE n 
1 293 PHE n 
1 294 ILE n 
1 295 LEU n 
1 296 VAL n 
1 297 GLU n 
1 298 ALA n 
1 299 LEU n 
1 300 GLY n 
1 301 SER n 
1 302 THR n 
1 303 SER n 
1 304 HIS n 
1 305 SER n 
1 306 THR n 
1 307 ALA n 
1 308 ALA n 
1 309 LEU n 
1 310 SER n 
1 311 SER n 
1 312 TYR n 
1 313 TYR n 
1 314 PHE n 
1 315 CYS n 
1 316 ILE n 
1 317 ALA n 
1 318 LEU n 
1 319 GLY n 
1 320 TYR n 
1 321 THR n 
1 322 ASN n 
1 323 SER n 
1 324 SER n 
1 325 LEU n 
1 326 ASN n 
1 327 PRO n 
1 328 ILE n 
1 329 LEU n 
1 330 TYR n 
1 331 ALA n 
1 332 PHE n 
1 333 LEU n 
1 334 ASP n 
1 335 GLU n 
1 336 ASN n 
1 337 PHE n 
1 338 LYS n 
1 339 ARG n 
1 340 CYS n 
1 341 PHE n 
1 342 ARG n 
1 343 ASP n 
1 344 PHE n 
1 345 CYS n 
1 346 PHE n 
1 347 PRO n 
1 348 LEU n 
1 349 LYS n 
1 350 MET n 
1 351 ARG n 
1 352 MET n 
1 353 GLU n 
1 354 ARG n 
1 355 GLN n 
1 356 SER n 
1 357 THR n 
1 358 SER n 
1 359 ARG n 
1 360 VAL n 
1 361 ARG n 
1 362 ASN n 
1 363 THR n 
1 364 VAL n 
1 365 GLN n 
1 366 ASP n 
1 367 PRO n 
1 368 ALA n 
1 369 TYR n 
1 370 LEU n 
1 371 ARG n 
1 372 ASP n 
1 373 ILE n 
1 374 ASP n 
1 375 GLY n 
1 376 MET n 
1 377 ASN n 
1 378 LYS n 
1 379 PRO n 
1 380 VAL n 
2 1   MET n 
2 2   SER n 
2 3   GLU n 
2 4   LEU n 
2 5   ASP n 
2 6   GLN n 
2 7   LEU n 
2 8   ARG n 
2 9   GLN n 
2 10  GLU n 
2 11  ALA n 
2 12  GLU n 
2 13  GLN n 
2 14  LEU n 
2 15  LYS n 
2 16  ASN n 
2 17  GLN n 
2 18  ILE n 
2 19  ARG n 
2 20  ASP n 
2 21  ALA n 
2 22  ARG n 
2 23  LYS n 
2 24  ALA n 
2 25  CYS n 
2 26  ALA n 
2 27  ASP n 
2 28  ALA n 
2 29  THR n 
2 30  LEU n 
2 31  SER n 
2 32  GLN n 
2 33  ILE n 
2 34  THR n 
2 35  ASN n 
2 36  ASN n 
2 37  ILE n 
2 38  ASP n 
2 39  PRO n 
2 40  VAL n 
2 41  GLY n 
2 42  ARG n 
2 43  ILE n 
2 44  GLN n 
2 45  MET n 
2 46  ARG n 
2 47  THR n 
2 48  ARG n 
2 49  ARG n 
2 50  THR n 
2 51  LEU n 
2 52  ARG n 
2 53  GLY n 
2 54  HIS n 
2 55  LEU n 
2 56  ALA n 
2 57  LYS n 
2 58  ILE n 
2 59  TYR n 
2 60  ALA n 
2 61  MET n 
2 62  HIS n 
2 63  TRP n 
2 64  GLY n 
2 65  THR n 
2 66  ASP n 
2 67  SER n 
2 68  ARG n 
2 69  LEU n 
2 70  LEU n 
2 71  VAL n 
2 72  SER n 
2 73  ALA n 
2 74  SER n 
2 75  GLN n 
2 76  ASP n 
2 77  GLY n 
2 78  LYS n 
2 79  LEU n 
2 80  ILE n 
2 81  ILE n 
2 82  TRP n 
2 83  ASP n 
2 84  SER n 
2 85  TYR n 
2 86  THR n 
2 87  THR n 
2 88  ASN n 
2 89  LYS n 
2 90  VAL n 
2 91  HIS n 
2 92  ALA n 
2 93  ILE n 
2 94  PRO n 
2 95  LEU n 
2 96  ARG n 
2 97  SER n 
2 98  SER n 
2 99  TRP n 
2 100 VAL n 
2 101 MET n 
2 102 THR n 
2 103 CYS n 
2 104 ALA n 
2 105 TYR n 
2 106 ALA n 
2 107 PRO n 
2 108 SER n 
2 109 GLY n 
2 110 ASN n 
2 111 TYR n 
2 112 VAL n 
2 113 ALA n 
2 114 CYS n 
2 115 GLY n 
2 116 GLY n 
2 117 LEU n 
2 118 ASP n 
2 119 ASN n 
2 120 ILE n 
2 121 CYS n 
2 122 SER n 
2 123 ILE n 
2 124 TYR n 
2 125 ASN n 
2 126 LEU n 
2 127 LYS n 
2 128 THR n 
2 129 ARG n 
2 130 GLU n 
2 131 GLY n 
2 132 ASN n 
2 133 VAL n 
2 134 ARG n 
2 135 VAL n 
2 136 SER n 
2 137 ARG n 
2 138 GLU n 
2 139 LEU n 
2 140 ALA n 
2 141 GLY n 
2 142 HIS n 
2 143 THR n 
2 144 GLY n 
2 145 TYR n 
2 146 LEU n 
2 147 SER n 
2 148 CYS n 
2 149 CYS n 
2 150 ARG n 
2 151 PHE n 
2 152 LEU n 
2 153 ASP n 
2 154 ASP n 
2 155 ASN n 
2 156 GLN n 
2 157 ILE n 
2 158 VAL n 
2 159 THR n 
2 160 SER n 
2 161 SER n 
2 162 GLY n 
2 163 ASP n 
2 164 THR n 
2 165 THR n 
2 166 CYS n 
2 167 ALA n 
2 168 LEU n 
2 169 TRP n 
2 170 ASP n 
2 171 ILE n 
2 172 GLU n 
2 173 THR n 
2 174 GLY n 
2 175 GLN n 
2 176 GLN n 
2 177 THR n 
2 178 THR n 
2 179 THR n 
2 180 PHE n 
2 181 THR n 
2 182 GLY n 
2 183 HIS n 
2 184 THR n 
2 185 GLY n 
2 186 ASP n 
2 187 VAL n 
2 188 MET n 
2 189 SER n 
2 190 LEU n 
2 191 SER n 
2 192 LEU n 
2 193 ALA n 
2 194 PRO n 
2 195 ASP n 
2 196 THR n 
2 197 ARG n 
2 198 LEU n 
2 199 PHE n 
2 200 VAL n 
2 201 SER n 
2 202 GLY n 
2 203 ALA n 
2 204 CYS n 
2 205 ASP n 
2 206 ALA n 
2 207 SER n 
2 208 ALA n 
2 209 LYS n 
2 210 LEU n 
2 211 TRP n 
2 212 ASP n 
2 213 VAL n 
2 214 ARG n 
2 215 GLU n 
2 216 GLY n 
2 217 MET n 
2 218 CYS n 
2 219 ARG n 
2 220 GLN n 
2 221 THR n 
2 222 PHE n 
2 223 THR n 
2 224 GLY n 
2 225 HIS n 
2 226 GLU n 
2 227 SER n 
2 228 ASP n 
2 229 ILE n 
2 230 ASN n 
2 231 ALA n 
2 232 ILE n 
2 233 CYS n 
2 234 PHE n 
2 235 PHE n 
2 236 PRO n 
2 237 ASN n 
2 238 GLY n 
2 239 ASN n 
2 240 ALA n 
2 241 PHE n 
2 242 ALA n 
2 243 THR n 
2 244 GLY n 
2 245 SER n 
2 246 ASP n 
2 247 ASP n 
2 248 ALA n 
2 249 THR n 
2 250 CYS n 
2 251 ARG n 
2 252 LEU n 
2 253 PHE n 
2 254 ASP n 
2 255 LEU n 
2 256 ARG n 
2 257 ALA n 
2 258 ASP n 
2 259 GLN n 
2 260 GLU n 
2 261 LEU n 
2 262 MET n 
2 263 THR n 
2 264 TYR n 
2 265 SER n 
2 266 HIS n 
2 267 ASP n 
2 268 ASN n 
2 269 ILE n 
2 270 ILE n 
2 271 CYS n 
2 272 GLY n 
2 273 ILE n 
2 274 THR n 
2 275 SER n 
2 276 VAL n 
2 277 SER n 
2 278 PHE n 
2 279 SER n 
2 280 LYS n 
2 281 SER n 
2 282 GLY n 
2 283 ARG n 
2 284 LEU n 
2 285 LEU n 
2 286 LEU n 
2 287 ALA n 
2 288 GLY n 
2 289 TYR n 
2 290 ASP n 
2 291 ASP n 
2 292 PHE n 
2 293 ASN n 
2 294 CYS n 
2 295 ASN n 
2 296 VAL n 
2 297 TRP n 
2 298 ASP n 
2 299 ALA n 
2 300 LEU n 
2 301 LYS n 
2 302 ALA n 
2 303 ASP n 
2 304 ARG n 
2 305 ALA n 
2 306 GLY n 
2 307 VAL n 
2 308 LEU n 
2 309 ALA n 
2 310 GLY n 
2 311 HIS n 
2 312 ASP n 
2 313 ASN n 
2 314 ARG n 
2 315 VAL n 
2 316 SER n 
2 317 CYS n 
2 318 LEU n 
2 319 GLY n 
2 320 VAL n 
2 321 THR n 
2 322 ASP n 
2 323 ASP n 
2 324 GLY n 
2 325 MET n 
2 326 ALA n 
2 327 VAL n 
2 328 ALA n 
2 329 THR n 
2 330 GLY n 
2 331 SER n 
2 332 TRP n 
2 333 ASP n 
2 334 SER n 
2 335 PHE n 
2 336 LEU n 
2 337 LYS n 
2 338 ILE n 
2 339 TRP n 
2 340 ASN n 
3 1   MET n 
3 2   ALA n 
3 3   SER n 
3 4   ASN n 
3 5   ASN n 
3 6   THR n 
3 7   ALA n 
3 8   SER n 
3 9   ILE n 
3 10  ALA n 
3 11  GLN n 
3 12  ALA n 
3 13  ARG n 
3 14  LYS n 
3 15  LEU n 
3 16  VAL n 
3 17  GLU n 
3 18  GLN n 
3 19  LEU n 
3 20  LYS n 
3 21  MET n 
3 22  GLU n 
3 23  ALA n 
3 24  ASN n 
3 25  ILE n 
3 26  ASP n 
3 27  ARG n 
3 28  ILE n 
3 29  LYS n 
3 30  VAL n 
3 31  SER n 
3 32  LYS n 
3 33  ALA n 
3 34  ALA n 
3 35  ALA n 
3 36  ASP n 
3 37  LEU n 
3 38  MET n 
3 39  ALA n 
3 40  TYR n 
3 41  CYS n 
3 42  GLU n 
3 43  ALA n 
3 44  HIS n 
3 45  ALA n 
3 46  LYS n 
3 47  GLU n 
3 48  ASP n 
3 49  PRO n 
3 50  LEU n 
3 51  LEU n 
3 52  THR n 
3 53  PRO n 
3 54  VAL n 
3 55  PRO n 
3 56  ALA n 
3 57  SER n 
3 58  GLU n 
3 59  ASN n 
3 60  PRO n 
3 61  PHE n 
3 62  ARG n 
3 63  GLU n 
3 64  LYS n 
3 65  LYS n 
3 66  PHE n 
3 67  PHE n 
3 68  CYS n 
3 69  ALA n 
3 70  ILE n 
3 71  LEU n 
4 1   MET n 
4 2   GLY n 
4 3   CYS n 
4 4   THR n 
4 5   LEU n 
4 6   SER n 
4 7   ALA n 
4 8   GLU n 
4 9   ASP n 
4 10  LYS n 
4 11  ALA n 
4 12  ALA n 
4 13  VAL n 
4 14  GLU n 
4 15  ARG n 
4 16  SER n 
4 17  LYS n 
4 18  MET n 
4 19  ILE n 
4 20  ASP n 
4 21  ARG n 
4 22  ASN n 
4 23  LEU n 
4 24  ARG n 
4 25  GLU n 
4 26  ASP n 
4 27  GLY n 
4 28  GLU n 
4 29  LYS n 
4 30  ALA n 
4 31  ALA n 
4 32  ARG n 
4 33  GLU n 
4 34  VAL n 
4 35  LYS n 
4 36  LEU n 
4 37  LEU n 
4 38  LEU n 
4 39  LEU n 
4 40  GLY n 
4 41  ALA n 
4 42  GLY n 
4 43  GLU n 
4 44  SER n 
4 45  GLY n 
4 46  LYS n 
4 47  SER n 
4 48  THR n 
4 49  ILE n 
4 50  VAL n 
4 51  LYS n 
4 52  GLN n 
4 53  MET n 
4 54  LYS n 
4 55  ILE n 
4 56  ILE n 
4 57  HIS n 
4 58  GLU n 
4 59  ALA n 
4 60  GLY n 
4 61  TYR n 
4 62  SER n 
4 63  GLU n 
4 64  GLU n 
4 65  GLU n 
4 66  CYS n 
4 67  LYS n 
4 68  GLN n 
4 69  TYR n 
4 70  LYS n 
4 71  ALA n 
4 72  VAL n 
4 73  VAL n 
4 74  TYR n 
4 75  SER n 
4 76  ASN n 
4 77  THR n 
4 78  ILE n 
4 79  GLN n 
4 80  SER n 
4 81  ILE n 
4 82  ILE n 
4 83  ALA n 
4 84  ILE n 
4 85  ILE n 
4 86  ARG n 
4 87  ALA n 
4 88  MET n 
4 89  GLY n 
4 90  ARG n 
4 91  LEU n 
4 92  LYS n 
4 93  ILE n 
4 94  ASP n 
4 95  PHE n 
4 96  GLY n 
4 97  ASP n 
4 98  SER n 
4 99  ALA n 
4 100 ARG n 
4 101 ALA n 
4 102 ASP n 
4 103 ASP n 
4 104 ALA n 
4 105 ARG n 
4 106 GLN n 
4 107 LEU n 
4 108 PHE n 
4 109 VAL n 
4 110 LEU n 
4 111 ALA n 
4 112 GLY n 
4 113 ALA n 
4 114 ALA n 
4 115 GLU n 
4 116 GLU n 
4 117 GLY n 
4 118 PHE n 
4 119 MET n 
4 120 THR n 
4 121 ALA n 
4 122 GLU n 
4 123 LEU n 
4 124 ALA n 
4 125 GLY n 
4 126 VAL n 
4 127 ILE n 
4 128 LYS n 
4 129 ARG n 
4 130 LEU n 
4 131 TRP n 
4 132 LYS n 
4 133 ASP n 
4 134 SER n 
4 135 GLY n 
4 136 VAL n 
4 137 GLN n 
4 138 ALA n 
4 139 CYS n 
4 140 PHE n 
4 141 ASN n 
4 142 ARG n 
4 143 SER n 
4 144 ARG n 
4 145 GLU n 
4 146 TYR n 
4 147 GLN n 
4 148 LEU n 
4 149 ASN n 
4 150 ASP n 
4 151 SER n 
4 152 ALA n 
4 153 ALA n 
4 154 TYR n 
4 155 TYR n 
4 156 LEU n 
4 157 ASN n 
4 158 ASP n 
4 159 LEU n 
4 160 ASP n 
4 161 ARG n 
4 162 ILE n 
4 163 ALA n 
4 164 GLN n 
4 165 PRO n 
4 166 ASN n 
4 167 TYR n 
4 168 ILE n 
4 169 PRO n 
4 170 THR n 
4 171 GLN n 
4 172 GLN n 
4 173 ASP n 
4 174 VAL n 
4 175 LEU n 
4 176 ARG n 
4 177 THR n 
4 178 ARG n 
4 179 VAL n 
4 180 LYS n 
4 181 THR n 
4 182 THR n 
4 183 GLY n 
4 184 ILE n 
4 185 VAL n 
4 186 GLU n 
4 187 THR n 
4 188 HIS n 
4 189 PHE n 
4 190 THR n 
4 191 PHE n 
4 192 LYS n 
4 193 ASP n 
4 194 LEU n 
4 195 HIS n 
4 196 PHE n 
4 197 LYS n 
4 198 MET n 
4 199 PHE n 
4 200 ASP n 
4 201 VAL n 
4 202 GLY n 
4 203 GLY n 
4 204 GLN n 
4 205 ARG n 
4 206 SER n 
4 207 GLU n 
4 208 ARG n 
4 209 LYS n 
4 210 LYS n 
4 211 TRP n 
4 212 ILE n 
4 213 HIS n 
4 214 CYS n 
4 215 PHE n 
4 216 GLU n 
4 217 GLY n 
4 218 VAL n 
4 219 THR n 
4 220 ALA n 
4 221 ILE n 
4 222 ILE n 
4 223 PHE n 
4 224 CYS n 
4 225 VAL n 
4 226 ALA n 
4 227 LEU n 
4 228 SER n 
4 229 ASP n 
4 230 TYR n 
4 231 ASP n 
4 232 LEU n 
4 233 VAL n 
4 234 LEU n 
4 235 ALA n 
4 236 GLU n 
4 237 ASP n 
4 238 GLU n 
4 239 GLU n 
4 240 MET n 
4 241 ASN n 
4 242 ARG n 
4 243 MET n 
4 244 HIS n 
4 245 GLU n 
4 246 SER n 
4 247 MET n 
4 248 LYS n 
4 249 LEU n 
4 250 PHE n 
4 251 ASP n 
4 252 SER n 
4 253 ILE n 
4 254 CYS n 
4 255 ASN n 
4 256 ASN n 
4 257 LYS n 
4 258 TRP n 
4 259 PHE n 
4 260 THR n 
4 261 ASP n 
4 262 THR n 
4 263 SER n 
4 264 ILE n 
4 265 ILE n 
4 266 LEU n 
4 267 PHE n 
4 268 LEU n 
4 269 ASN n 
4 270 LYS n 
4 271 LYS n 
4 272 ASP n 
4 273 LEU n 
4 274 PHE n 
4 275 GLU n 
4 276 GLU n 
4 277 LYS n 
4 278 ILE n 
4 279 LYS n 
4 280 LYS n 
4 281 SER n 
4 282 PRO n 
4 283 LEU n 
4 284 THR n 
4 285 ILE n 
4 286 CYS n 
4 287 TYR n 
4 288 PRO n 
4 289 GLU n 
4 290 TYR n 
4 291 ALA n 
4 292 GLY n 
4 293 SER n 
4 294 ASN n 
4 295 THR n 
4 296 TYR n 
4 297 GLU n 
4 298 GLU n 
4 299 ALA n 
4 300 ALA n 
4 301 ALA n 
4 302 TYR n 
4 303 ILE n 
4 304 GLN n 
4 305 CYS n 
4 306 GLN n 
4 307 PHE n 
4 308 GLU n 
4 309 ASP n 
4 310 LEU n 
4 311 ASN n 
4 312 LYS n 
4 313 ARG n 
4 314 LYS n 
4 315 ASP n 
4 316 THR n 
4 317 LYS n 
4 318 GLU n 
4 319 ILE n 
4 320 TYR n 
4 321 THR n 
4 322 HIS n 
4 323 PHE n 
4 324 THR n 
4 325 CYS n 
4 326 ALA n 
4 327 THR n 
4 328 ASP n 
4 329 THR n 
4 330 LYS n 
4 331 ASN n 
4 332 VAL n 
4 333 GLN n 
4 334 PHE n 
4 335 VAL n 
4 336 PHE n 
4 337 ASP n 
4 338 ALA n 
4 339 VAL n 
4 340 THR n 
4 341 ASP n 
4 342 VAL n 
4 343 ILE n 
4 344 ILE n 
4 345 LYS n 
4 346 ASN n 
4 347 ASN n 
4 348 LEU n 
4 349 LYS n 
4 350 ASP n 
4 351 CYS n 
4 352 GLY n 
4 353 LEU n 
4 354 PHE n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 380 human ? 'OPRK1, OPRK' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? 'fall armyworm' 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 340 human ? GNB1          ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? 'fall armyworm' 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 71  human ? GNG2          ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? 'fall armyworm' 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
4 1 sample 'Biological sequence' 1 354 human ? GNAI1         ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? 'fall armyworm' 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2'    131.173 
JDC non-polymer         . 
;(3R)-7-hydroxy-N-{(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl}-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
;
? 'C28 H39 N3 O3'  465.628 
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   ASP 2   2   ?   ?   ?   A . n 
A 1 3   SER 3   3   ?   ?   ?   A . n 
A 1 4   PRO 4   4   ?   ?   ?   A . n 
A 1 5   ILE 5   5   ?   ?   ?   A . n 
A 1 6   GLN 6   6   ?   ?   ?   A . n 
A 1 7   ILE 7   7   ?   ?   ?   A . n 
A 1 8   PHE 8   8   ?   ?   ?   A . n 
A 1 9   ARG 9   9   ?   ?   ?   A . n 
A 1 10  GLY 10  10  ?   ?   ?   A . n 
A 1 11  GLU 11  11  ?   ?   ?   A . n 
A 1 12  PRO 12  12  ?   ?   ?   A . n 
A 1 13  GLY 13  13  ?   ?   ?   A . n 
A 1 14  PRO 14  14  ?   ?   ?   A . n 
A 1 15  THR 15  15  ?   ?   ?   A . n 
A 1 16  CYS 16  16  ?   ?   ?   A . n 
A 1 17  ALA 17  17  ?   ?   ?   A . n 
A 1 18  PRO 18  18  ?   ?   ?   A . n 
A 1 19  SER 19  19  ?   ?   ?   A . n 
A 1 20  ALA 20  20  ?   ?   ?   A . n 
A 1 21  CYS 21  21  ?   ?   ?   A . n 
A 1 22  LEU 22  22  ?   ?   ?   A . n 
A 1 23  PRO 23  23  ?   ?   ?   A . n 
A 1 24  PRO 24  24  ?   ?   ?   A . n 
A 1 25  ASN 25  25  ?   ?   ?   A . n 
A 1 26  SER 26  26  ?   ?   ?   A . n 
A 1 27  SER 27  27  ?   ?   ?   A . n 
A 1 28  ALA 28  28  ?   ?   ?   A . n 
A 1 29  TRP 29  29  ?   ?   ?   A . n 
A 1 30  PHE 30  30  ?   ?   ?   A . n 
A 1 31  PRO 31  31  ?   ?   ?   A . n 
A 1 32  GLY 32  32  ?   ?   ?   A . n 
A 1 33  TRP 33  33  ?   ?   ?   A . n 
A 1 34  ALA 34  34  ?   ?   ?   A . n 
A 1 35  GLU 35  35  ?   ?   ?   A . n 
A 1 36  PRO 36  36  ?   ?   ?   A . n 
A 1 37  ASP 37  37  ?   ?   ?   A . n 
A 1 38  SER 38  38  ?   ?   ?   A . n 
A 1 39  ASN 39  39  ?   ?   ?   A . n 
A 1 40  GLY 40  40  ?   ?   ?   A . n 
A 1 41  SER 41  41  ?   ?   ?   A . n 
A 1 42  ALA 42  42  ?   ?   ?   A . n 
A 1 43  GLY 43  43  ?   ?   ?   A . n 
A 1 44  SER 44  44  ?   ?   ?   A . n 
A 1 45  GLU 45  45  ?   ?   ?   A . n 
A 1 46  ASP 46  46  ?   ?   ?   A . n 
A 1 47  ALA 47  47  ?   ?   ?   A . n 
A 1 48  GLN 48  48  ?   ?   ?   A . n 
A 1 49  LEU 49  49  ?   ?   ?   A . n 
A 1 50  GLU 50  50  ?   ?   ?   A . n 
A 1 51  PRO 51  51  ?   ?   ?   A . n 
A 1 52  ALA 52  52  ?   ?   ?   A . n 
A 1 53  HIS 53  53  ?   ?   ?   A . n 
A 1 54  ILE 54  54  ?   ?   ?   A . n 
A 1 55  SER 55  55  ?   ?   ?   A . n 
A 1 56  PRO 56  56  ?   ?   ?   A . n 
A 1 57  ALA 57  57  57  ALA ALA A . n 
A 1 58  ILE 58  58  58  ILE ILE A . n 
A 1 59  PRO 59  59  59  PRO PRO A . n 
A 1 60  VAL 60  60  60  VAL VAL A . n 
A 1 61  ILE 61  61  61  ILE ILE A . n 
A 1 62  ILE 62  62  62  ILE ILE A . n 
A 1 63  THR 63  63  63  THR THR A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  VAL 65  65  65  VAL VAL A . n 
A 1 66  TYR 66  66  66  TYR TYR A . n 
A 1 67  SER 67  67  67  SER SER A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  VAL 69  69  69  VAL VAL A . n 
A 1 70  PHE 70  70  70  PHE PHE A . n 
A 1 71  VAL 71  71  71  VAL VAL A . n 
A 1 72  VAL 72  72  72  VAL VAL A . n 
A 1 73  GLY 73  73  73  GLY GLY A . n 
A 1 74  LEU 74  74  74  LEU LEU A . n 
A 1 75  VAL 75  75  75  VAL VAL A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  SER 78  78  78  SER SER A . n 
A 1 79  LEU 79  79  79  LEU LEU A . n 
A 1 80  VAL 80  80  80  VAL VAL A . n 
A 1 81  MET 81  81  81  MET MET A . n 
A 1 82  PHE 82  82  82  PHE PHE A . n 
A 1 83  VAL 83  83  83  VAL VAL A . n 
A 1 84  ILE 84  84  84  ILE ILE A . n 
A 1 85  ILE 85  85  85  ILE ILE A . n 
A 1 86  ARG 86  86  86  ARG ARG A . n 
A 1 87  TYR 87  87  87  TYR TYR A . n 
A 1 88  THR 88  88  88  THR THR A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  MET 90  90  90  MET MET A . n 
A 1 91  LYS 91  91  91  LYS LYS A . n 
A 1 92  THR 92  92  92  THR THR A . n 
A 1 93  ALA 93  93  93  ALA ALA A . n 
A 1 94  THR 94  94  94  THR THR A . n 
A 1 95  ASN 95  95  95  ASN ASN A . n 
A 1 96  ILE 96  96  96  ILE ILE A . n 
A 1 97  TYR 97  97  97  TYR TYR A . n 
A 1 98  ILE 98  98  98  ILE ILE A . n 
A 1 99  PHE 99  99  99  PHE PHE A . n 
A 1 100 ASN 100 100 100 ASN ASN A . n 
A 1 101 LEU 101 101 101 LEU LEU A . n 
A 1 102 ALA 102 102 102 ALA ALA A . n 
A 1 103 LEU 103 103 103 LEU LEU A . n 
A 1 104 ALA 104 104 104 ALA ALA A . n 
A 1 105 ASP 105 105 105 ASP ASP A . n 
A 1 106 ALA 106 106 106 ALA ALA A . n 
A 1 107 LEU 107 107 107 LEU LEU A . n 
A 1 108 VAL 108 108 108 VAL VAL A . n 
A 1 109 THR 109 109 109 THR THR A . n 
A 1 110 THR 110 110 110 THR THR A . n 
A 1 111 THR 111 111 111 THR THR A . n 
A 1 112 MET 112 112 112 MET MET A . n 
A 1 113 PRO 113 113 113 PRO PRO A . n 
A 1 114 PHE 114 114 114 PHE PHE A . n 
A 1 115 GLN 115 115 115 GLN GLN A . n 
A 1 116 SER 116 116 116 SER SER A . n 
A 1 117 THR 117 117 117 THR THR A . n 
A 1 118 VAL 118 118 118 VAL VAL A . n 
A 1 119 TYR 119 119 119 TYR TYR A . n 
A 1 120 LEU 120 120 120 LEU LEU A . n 
A 1 121 MET 121 121 121 MET MET A . n 
A 1 122 ASN 122 122 122 ASN ASN A . n 
A 1 123 SER 123 123 123 SER SER A . n 
A 1 124 TRP 124 124 124 TRP TRP A . n 
A 1 125 PRO 125 125 125 PRO PRO A . n 
A 1 126 PHE 126 126 126 PHE PHE A . n 
A 1 127 GLY 127 127 127 GLY GLY A . n 
A 1 128 ASP 128 128 128 ASP ASP A . n 
A 1 129 VAL 129 129 129 VAL VAL A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 CYS 131 131 131 CYS CYS A . n 
A 1 132 LYS 132 132 132 LYS LYS A . n 
A 1 133 ILE 133 133 133 ILE ILE A . n 
A 1 134 VAL 134 134 134 VAL VAL A . n 
A 1 135 ILE 135 135 135 ILE ILE A . n 
A 1 136 SER 136 136 136 SER SER A . n 
A 1 137 ILE 137 137 137 ILE ILE A . n 
A 1 138 ASP 138 138 138 ASP ASP A . n 
A 1 139 TYR 139 139 139 TYR TYR A . n 
A 1 140 TYR 140 140 140 TYR TYR A . n 
A 1 141 ASN 141 141 141 ASN ASN A . n 
A 1 142 MET 142 142 142 MET MET A . n 
A 1 143 PHE 143 143 143 PHE PHE A . n 
A 1 144 THR 144 144 144 THR THR A . n 
A 1 145 SER 145 145 145 SER SER A . n 
A 1 146 ILE 146 146 146 ILE ILE A . n 
A 1 147 PHE 147 147 147 PHE PHE A . n 
A 1 148 THR 148 148 148 THR THR A . n 
A 1 149 LEU 149 149 149 LEU LEU A . n 
A 1 150 THR 150 150 150 THR THR A . n 
A 1 151 MET 151 151 151 MET MET A . n 
A 1 152 MET 152 152 152 MET MET A . n 
A 1 153 SER 153 153 153 SER SER A . n 
A 1 154 VAL 154 154 154 VAL VAL A . n 
A 1 155 ASP 155 155 155 ASP ASP A . n 
A 1 156 ARG 156 156 156 ARG ARG A . n 
A 1 157 TYR 157 157 157 TYR TYR A . n 
A 1 158 ILE 158 158 158 ILE ILE A . n 
A 1 159 ALA 159 159 159 ALA ALA A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 CYS 161 161 161 CYS CYS A . n 
A 1 162 HIS 162 162 162 HIS HIS A . n 
A 1 163 PRO 163 163 163 PRO PRO A . n 
A 1 164 VAL 164 164 164 VAL VAL A . n 
A 1 165 LYS 165 165 165 LYS LYS A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 LEU 167 167 167 LEU LEU A . n 
A 1 168 ASP 168 168 168 ASP ASP A . n 
A 1 169 PHE 169 169 169 PHE PHE A . n 
A 1 170 ARG 170 170 170 ARG ARG A . n 
A 1 171 THR 171 171 171 THR THR A . n 
A 1 172 PRO 172 172 172 PRO PRO A . n 
A 1 173 LEU 173 173 173 LEU LEU A . n 
A 1 174 LYS 174 174 174 LYS LYS A . n 
A 1 175 ALA 175 175 175 ALA ALA A . n 
A 1 176 LYS 176 176 176 LYS LYS A . n 
A 1 177 ILE 177 177 177 ILE ILE A . n 
A 1 178 ILE 178 178 178 ILE ILE A . n 
A 1 179 ASN 179 179 179 ASN ASN A . n 
A 1 180 ILE 180 180 180 ILE ILE A . n 
A 1 181 CYS 181 181 181 CYS CYS A . n 
A 1 182 ILE 182 182 182 ILE ILE A . n 
A 1 183 TRP 183 183 183 TRP TRP A . n 
A 1 184 LEU 184 184 184 LEU LEU A . n 
A 1 185 LEU 185 185 185 LEU LEU A . n 
A 1 186 SER 186 186 186 SER SER A . n 
A 1 187 SER 187 187 187 SER SER A . n 
A 1 188 SER 188 188 188 SER SER A . n 
A 1 189 VAL 189 189 189 VAL VAL A . n 
A 1 190 GLY 190 190 190 GLY GLY A . n 
A 1 191 ILE 191 191 191 ILE ILE A . n 
A 1 192 SER 192 192 192 SER SER A . n 
A 1 193 ALA 193 193 193 ALA ALA A . n 
A 1 194 ILE 194 194 194 ILE ILE A . n 
A 1 195 VAL 195 195 195 VAL VAL A . n 
A 1 196 LEU 196 196 196 LEU LEU A . n 
A 1 197 GLY 197 197 197 GLY GLY A . n 
A 1 198 GLY 198 198 198 GLY GLY A . n 
A 1 199 THR 199 199 199 THR THR A . n 
A 1 200 LYS 200 200 200 LYS LYS A . n 
A 1 201 VAL 201 201 201 VAL VAL A . n 
A 1 202 ARG 202 202 202 ARG ARG A . n 
A 1 203 GLU 203 203 203 GLU GLU A . n 
A 1 204 ASP 204 204 204 ASP ASP A . n 
A 1 205 VAL 205 205 205 VAL VAL A . n 
A 1 206 ASP 206 206 206 ASP ASP A . n 
A 1 207 VAL 207 207 207 VAL VAL A . n 
A 1 208 ILE 208 208 208 ILE ILE A . n 
A 1 209 GLU 209 209 209 GLU GLU A . n 
A 1 210 CYS 210 210 210 CYS CYS A . n 
A 1 211 SER 211 211 211 SER SER A . n 
A 1 212 LEU 212 212 212 LEU LEU A . n 
A 1 213 GLN 213 213 213 GLN GLN A . n 
A 1 214 PHE 214 214 214 PHE PHE A . n 
A 1 215 PRO 215 215 215 PRO PRO A . n 
A 1 216 ASP 216 216 216 ASP ASP A . n 
A 1 217 ASP 217 217 217 ASP ASP A . n 
A 1 218 ASP 218 218 218 ASP ASP A . n 
A 1 219 TYR 219 219 219 TYR TYR A . n 
A 1 220 SER 220 220 220 SER SER A . n 
A 1 221 TRP 221 221 221 TRP TRP A . n 
A 1 222 TRP 222 222 222 TRP TRP A . n 
A 1 223 ASP 223 223 223 ASP ASP A . n 
A 1 224 LEU 224 224 224 LEU LEU A . n 
A 1 225 PHE 225 225 225 PHE PHE A . n 
A 1 226 MET 226 226 226 MET MET A . n 
A 1 227 LYS 227 227 227 LYS LYS A . n 
A 1 228 ILE 228 228 228 ILE ILE A . n 
A 1 229 CYS 229 229 229 CYS CYS A . n 
A 1 230 VAL 230 230 230 VAL VAL A . n 
A 1 231 PHE 231 231 231 PHE PHE A . n 
A 1 232 ILE 232 232 232 ILE ILE A . n 
A 1 233 PHE 233 233 233 PHE PHE A . n 
A 1 234 ALA 234 234 234 ALA ALA A . n 
A 1 235 PHE 235 235 235 PHE PHE A . n 
A 1 236 VAL 236 236 236 VAL VAL A . n 
A 1 237 ILE 237 237 237 ILE ILE A . n 
A 1 238 PRO 238 238 238 PRO PRO A . n 
A 1 239 VAL 239 239 239 VAL VAL A . n 
A 1 240 LEU 240 240 240 LEU LEU A . n 
A 1 241 ILE 241 241 241 ILE ILE A . n 
A 1 242 ILE 242 242 242 ILE ILE A . n 
A 1 243 ILE 243 243 243 ILE ILE A . n 
A 1 244 VAL 244 244 244 VAL VAL A . n 
A 1 245 CYS 245 245 245 CYS CYS A . n 
A 1 246 TYR 246 246 246 TYR TYR A . n 
A 1 247 THR 247 247 247 THR THR A . n 
A 1 248 LEU 248 248 248 LEU LEU A . n 
A 1 249 MET 249 249 249 MET MET A . n 
A 1 250 ILE 250 250 250 ILE ILE A . n 
A 1 251 LEU 251 251 251 LEU LEU A . n 
A 1 252 ARG 252 252 252 ARG ARG A . n 
A 1 253 LEU 253 253 253 LEU LEU A . n 
A 1 254 LYS 254 254 254 LYS LYS A . n 
A 1 255 SER 255 255 255 SER SER A . n 
A 1 256 VAL 256 256 256 VAL VAL A . n 
A 1 257 ARG 257 257 257 ARG ARG A . n 
A 1 258 LEU 258 258 258 LEU LEU A . n 
A 1 259 LEU 259 259 259 LEU LEU A . n 
A 1 260 SER 260 260 260 SER SER A . n 
A 1 261 GLY 261 261 261 GLY GLY A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 ARG 263 263 263 ARG ARG A . n 
A 1 264 GLU 264 264 264 GLU GLU A . n 
A 1 265 LYS 265 265 265 LYS LYS A . n 
A 1 266 ASP 266 266 266 ASP ASP A . n 
A 1 267 ARG 267 267 267 ARG ARG A . n 
A 1 268 ASN 268 268 268 ASN ASN A . n 
A 1 269 LEU 269 269 269 LEU LEU A . n 
A 1 270 ARG 270 270 270 ARG ARG A . n 
A 1 271 ARG 271 271 271 ARG ARG A . n 
A 1 272 ILE 272 272 272 ILE ILE A . n 
A 1 273 THR 273 273 273 THR THR A . n 
A 1 274 ARG 274 274 274 ARG ARG A . n 
A 1 275 LEU 275 275 275 LEU LEU A . n 
A 1 276 VAL 276 276 276 VAL VAL A . n 
A 1 277 LEU 277 277 277 LEU LEU A . n 
A 1 278 VAL 278 278 278 VAL VAL A . n 
A 1 279 VAL 279 279 279 VAL VAL A . n 
A 1 280 VAL 280 280 280 VAL VAL A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 VAL 282 282 282 VAL VAL A . n 
A 1 283 PHE 283 283 283 PHE PHE A . n 
A 1 284 VAL 284 284 284 VAL VAL A . n 
A 1 285 VAL 285 285 285 VAL VAL A . n 
A 1 286 CYS 286 286 286 CYS CYS A . n 
A 1 287 TRP 287 287 287 TRP TRP A . n 
A 1 288 THR 288 288 288 THR THR A . n 
A 1 289 PRO 289 289 289 PRO PRO A . n 
A 1 290 ILE 290 290 290 ILE ILE A . n 
A 1 291 HIS 291 291 291 HIS HIS A . n 
A 1 292 ILE 292 292 292 ILE ILE A . n 
A 1 293 PHE 293 293 293 PHE PHE A . n 
A 1 294 ILE 294 294 294 ILE ILE A . n 
A 1 295 LEU 295 295 295 LEU LEU A . n 
A 1 296 VAL 296 296 296 VAL VAL A . n 
A 1 297 GLU 297 297 297 GLU GLU A . n 
A 1 298 ALA 298 298 298 ALA ALA A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 GLY 300 300 300 GLY GLY A . n 
A 1 301 SER 301 301 301 SER SER A . n 
A 1 302 THR 302 302 302 THR THR A . n 
A 1 303 SER 303 303 303 SER SER A . n 
A 1 304 HIS 304 304 304 HIS HIS A . n 
A 1 305 SER 305 305 305 SER SER A . n 
A 1 306 THR 306 306 306 THR THR A . n 
A 1 307 ALA 307 307 307 ALA ALA A . n 
A 1 308 ALA 308 308 308 ALA ALA A . n 
A 1 309 LEU 309 309 309 LEU LEU A . n 
A 1 310 SER 310 310 310 SER SER A . n 
A 1 311 SER 311 311 311 SER SER A . n 
A 1 312 TYR 312 312 312 TYR TYR A . n 
A 1 313 TYR 313 313 313 TYR TYR A . n 
A 1 314 PHE 314 314 314 PHE PHE A . n 
A 1 315 CYS 315 315 315 CYS CYS A . n 
A 1 316 ILE 316 316 316 ILE ILE A . n 
A 1 317 ALA 317 317 317 ALA ALA A . n 
A 1 318 LEU 318 318 318 LEU LEU A . n 
A 1 319 GLY 319 319 319 GLY GLY A . n 
A 1 320 TYR 320 320 320 TYR TYR A . n 
A 1 321 THR 321 321 321 THR THR A . n 
A 1 322 ASN 322 322 322 ASN ASN A . n 
A 1 323 SER 323 323 323 SER SER A . n 
A 1 324 SER 324 324 324 SER SER A . n 
A 1 325 LEU 325 325 325 LEU LEU A . n 
A 1 326 ASN 326 326 326 ASN ASN A . n 
A 1 327 PRO 327 327 327 PRO PRO A . n 
A 1 328 ILE 328 328 328 ILE ILE A . n 
A 1 329 LEU 329 329 329 LEU LEU A . n 
A 1 330 TYR 330 330 330 TYR TYR A . n 
A 1 331 ALA 331 331 331 ALA ALA A . n 
A 1 332 PHE 332 332 332 PHE PHE A . n 
A 1 333 LEU 333 333 333 LEU LEU A . n 
A 1 334 ASP 334 334 334 ASP ASP A . n 
A 1 335 GLU 335 335 335 GLU GLU A . n 
A 1 336 ASN 336 336 336 ASN ASN A . n 
A 1 337 PHE 337 337 337 PHE PHE A . n 
A 1 338 LYS 338 338 338 LYS LYS A . n 
A 1 339 ARG 339 339 339 ARG ARG A . n 
A 1 340 CYS 340 340 340 CYS CYS A . n 
A 1 341 PHE 341 341 341 PHE PHE A . n 
A 1 342 ARG 342 342 342 ARG ARG A . n 
A 1 343 ASP 343 343 ?   ?   ?   A . n 
A 1 344 PHE 344 344 ?   ?   ?   A . n 
A 1 345 CYS 345 345 ?   ?   ?   A . n 
A 1 346 PHE 346 346 ?   ?   ?   A . n 
A 1 347 PRO 347 347 ?   ?   ?   A . n 
A 1 348 LEU 348 348 ?   ?   ?   A . n 
A 1 349 LYS 349 349 ?   ?   ?   A . n 
A 1 350 MET 350 350 ?   ?   ?   A . n 
A 1 351 ARG 351 351 ?   ?   ?   A . n 
A 1 352 MET 352 352 ?   ?   ?   A . n 
A 1 353 GLU 353 353 ?   ?   ?   A . n 
A 1 354 ARG 354 354 ?   ?   ?   A . n 
A 1 355 GLN 355 355 ?   ?   ?   A . n 
A 1 356 SER 356 356 ?   ?   ?   A . n 
A 1 357 THR 357 357 ?   ?   ?   A . n 
A 1 358 SER 358 358 ?   ?   ?   A . n 
A 1 359 ARG 359 359 ?   ?   ?   A . n 
A 1 360 VAL 360 360 ?   ?   ?   A . n 
A 1 361 ARG 361 361 ?   ?   ?   A . n 
A 1 362 ASN 362 362 ?   ?   ?   A . n 
A 1 363 THR 363 363 ?   ?   ?   A . n 
A 1 364 VAL 364 364 ?   ?   ?   A . n 
A 1 365 GLN 365 365 ?   ?   ?   A . n 
A 1 366 ASP 366 366 ?   ?   ?   A . n 
A 1 367 PRO 367 367 ?   ?   ?   A . n 
A 1 368 ALA 368 368 ?   ?   ?   A . n 
A 1 369 TYR 369 369 ?   ?   ?   A . n 
A 1 370 LEU 370 370 ?   ?   ?   A . n 
A 1 371 ARG 371 371 ?   ?   ?   A . n 
A 1 372 ASP 372 372 ?   ?   ?   A . n 
A 1 373 ILE 373 373 ?   ?   ?   A . n 
A 1 374 ASP 374 374 ?   ?   ?   A . n 
A 1 375 GLY 375 375 ?   ?   ?   A . n 
A 1 376 MET 376 376 ?   ?   ?   A . n 
A 1 377 ASN 377 377 ?   ?   ?   A . n 
A 1 378 LYS 378 378 ?   ?   ?   A . n 
A 1 379 PRO 379 379 ?   ?   ?   A . n 
A 1 380 VAL 380 380 ?   ?   ?   A . n 
B 2 1   MET 1   1   ?   ?   ?   C . n 
B 2 2   SER 2   2   2   SER SER C . n 
B 2 3   GLU 3   3   3   GLU GLU C . n 
B 2 4   LEU 4   4   4   LEU LEU C . n 
B 2 5   ASP 5   5   5   ASP ASP C . n 
B 2 6   GLN 6   6   6   GLN GLN C . n 
B 2 7   LEU 7   7   7   LEU LEU C . n 
B 2 8   ARG 8   8   8   ARG ARG C . n 
B 2 9   GLN 9   9   9   GLN GLN C . n 
B 2 10  GLU 10  10  10  GLU GLU C . n 
B 2 11  ALA 11  11  11  ALA ALA C . n 
B 2 12  GLU 12  12  12  GLU GLU C . n 
B 2 13  GLN 13  13  13  GLN GLN C . n 
B 2 14  LEU 14  14  14  LEU LEU C . n 
B 2 15  LYS 15  15  15  LYS LYS C . n 
B 2 16  ASN 16  16  16  ASN ASN C . n 
B 2 17  GLN 17  17  17  GLN GLN C . n 
B 2 18  ILE 18  18  18  ILE ILE C . n 
B 2 19  ARG 19  19  19  ARG ARG C . n 
B 2 20  ASP 20  20  20  ASP ASP C . n 
B 2 21  ALA 21  21  21  ALA ALA C . n 
B 2 22  ARG 22  22  22  ARG ARG C . n 
B 2 23  LYS 23  23  23  LYS LYS C . n 
B 2 24  ALA 24  24  24  ALA ALA C . n 
B 2 25  CYS 25  25  25  CYS CYS C . n 
B 2 26  ALA 26  26  26  ALA ALA C . n 
B 2 27  ASP 27  27  27  ASP ASP C . n 
B 2 28  ALA 28  28  28  ALA ALA C . n 
B 2 29  THR 29  29  29  THR THR C . n 
B 2 30  LEU 30  30  30  LEU LEU C . n 
B 2 31  SER 31  31  31  SER SER C . n 
B 2 32  GLN 32  32  32  GLN GLN C . n 
B 2 33  ILE 33  33  33  ILE ILE C . n 
B 2 34  THR 34  34  34  THR THR C . n 
B 2 35  ASN 35  35  35  ASN ASN C . n 
B 2 36  ASN 36  36  36  ASN ASN C . n 
B 2 37  ILE 37  37  37  ILE ILE C . n 
B 2 38  ASP 38  38  38  ASP ASP C . n 
B 2 39  PRO 39  39  39  PRO PRO C . n 
B 2 40  VAL 40  40  40  VAL VAL C . n 
B 2 41  GLY 41  41  41  GLY GLY C . n 
B 2 42  ARG 42  42  42  ARG ARG C . n 
B 2 43  ILE 43  43  43  ILE ILE C . n 
B 2 44  GLN 44  44  44  GLN GLN C . n 
B 2 45  MET 45  45  45  MET MET C . n 
B 2 46  ARG 46  46  46  ARG ARG C . n 
B 2 47  THR 47  47  47  THR THR C . n 
B 2 48  ARG 48  48  48  ARG ARG C . n 
B 2 49  ARG 49  49  49  ARG ARG C . n 
B 2 50  THR 50  50  50  THR THR C . n 
B 2 51  LEU 51  51  51  LEU LEU C . n 
B 2 52  ARG 52  52  52  ARG ARG C . n 
B 2 53  GLY 53  53  53  GLY GLY C . n 
B 2 54  HIS 54  54  54  HIS HIS C . n 
B 2 55  LEU 55  55  55  LEU LEU C . n 
B 2 56  ALA 56  56  56  ALA ALA C . n 
B 2 57  LYS 57  57  57  LYS LYS C . n 
B 2 58  ILE 58  58  58  ILE ILE C . n 
B 2 59  TYR 59  59  59  TYR TYR C . n 
B 2 60  ALA 60  60  60  ALA ALA C . n 
B 2 61  MET 61  61  61  MET MET C . n 
B 2 62  HIS 62  62  62  HIS HIS C . n 
B 2 63  TRP 63  63  63  TRP TRP C . n 
B 2 64  GLY 64  64  64  GLY GLY C . n 
B 2 65  THR 65  65  65  THR THR C . n 
B 2 66  ASP 66  66  66  ASP ASP C . n 
B 2 67  SER 67  67  67  SER SER C . n 
B 2 68  ARG 68  68  68  ARG ARG C . n 
B 2 69  LEU 69  69  69  LEU LEU C . n 
B 2 70  LEU 70  70  70  LEU LEU C . n 
B 2 71  VAL 71  71  71  VAL VAL C . n 
B 2 72  SER 72  72  72  SER SER C . n 
B 2 73  ALA 73  73  73  ALA ALA C . n 
B 2 74  SER 74  74  74  SER SER C . n 
B 2 75  GLN 75  75  75  GLN GLN C . n 
B 2 76  ASP 76  76  76  ASP ASP C . n 
B 2 77  GLY 77  77  77  GLY GLY C . n 
B 2 78  LYS 78  78  78  LYS LYS C . n 
B 2 79  LEU 79  79  79  LEU LEU C . n 
B 2 80  ILE 80  80  80  ILE ILE C . n 
B 2 81  ILE 81  81  81  ILE ILE C . n 
B 2 82  TRP 82  82  82  TRP TRP C . n 
B 2 83  ASP 83  83  83  ASP ASP C . n 
B 2 84  SER 84  84  84  SER SER C . n 
B 2 85  TYR 85  85  85  TYR TYR C . n 
B 2 86  THR 86  86  86  THR THR C . n 
B 2 87  THR 87  87  87  THR THR C . n 
B 2 88  ASN 88  88  88  ASN ASN C . n 
B 2 89  LYS 89  89  89  LYS LYS C . n 
B 2 90  VAL 90  90  90  VAL VAL C . n 
B 2 91  HIS 91  91  91  HIS HIS C . n 
B 2 92  ALA 92  92  92  ALA ALA C . n 
B 2 93  ILE 93  93  93  ILE ILE C . n 
B 2 94  PRO 94  94  94  PRO PRO C . n 
B 2 95  LEU 95  95  95  LEU LEU C . n 
B 2 96  ARG 96  96  96  ARG ARG C . n 
B 2 97  SER 97  97  97  SER SER C . n 
B 2 98  SER 98  98  98  SER SER C . n 
B 2 99  TRP 99  99  99  TRP TRP C . n 
B 2 100 VAL 100 100 100 VAL VAL C . n 
B 2 101 MET 101 101 101 MET MET C . n 
B 2 102 THR 102 102 102 THR THR C . n 
B 2 103 CYS 103 103 103 CYS CYS C . n 
B 2 104 ALA 104 104 104 ALA ALA C . n 
B 2 105 TYR 105 105 105 TYR TYR C . n 
B 2 106 ALA 106 106 106 ALA ALA C . n 
B 2 107 PRO 107 107 107 PRO PRO C . n 
B 2 108 SER 108 108 108 SER SER C . n 
B 2 109 GLY 109 109 109 GLY GLY C . n 
B 2 110 ASN 110 110 110 ASN ASN C . n 
B 2 111 TYR 111 111 111 TYR TYR C . n 
B 2 112 VAL 112 112 112 VAL VAL C . n 
B 2 113 ALA 113 113 113 ALA ALA C . n 
B 2 114 CYS 114 114 114 CYS CYS C . n 
B 2 115 GLY 115 115 115 GLY GLY C . n 
B 2 116 GLY 116 116 116 GLY GLY C . n 
B 2 117 LEU 117 117 117 LEU LEU C . n 
B 2 118 ASP 118 118 118 ASP ASP C . n 
B 2 119 ASN 119 119 119 ASN ASN C . n 
B 2 120 ILE 120 120 120 ILE ILE C . n 
B 2 121 CYS 121 121 121 CYS CYS C . n 
B 2 122 SER 122 122 122 SER SER C . n 
B 2 123 ILE 123 123 123 ILE ILE C . n 
B 2 124 TYR 124 124 124 TYR TYR C . n 
B 2 125 ASN 125 125 125 ASN ASN C . n 
B 2 126 LEU 126 126 126 LEU LEU C . n 
B 2 127 LYS 127 127 127 LYS LYS C . n 
B 2 128 THR 128 128 128 THR THR C . n 
B 2 129 ARG 129 129 129 ARG ARG C . n 
B 2 130 GLU 130 130 130 GLU GLU C . n 
B 2 131 GLY 131 131 131 GLY GLY C . n 
B 2 132 ASN 132 132 132 ASN ASN C . n 
B 2 133 VAL 133 133 133 VAL VAL C . n 
B 2 134 ARG 134 134 134 ARG ARG C . n 
B 2 135 VAL 135 135 135 VAL VAL C . n 
B 2 136 SER 136 136 136 SER SER C . n 
B 2 137 ARG 137 137 137 ARG ARG C . n 
B 2 138 GLU 138 138 138 GLU GLU C . n 
B 2 139 LEU 139 139 139 LEU LEU C . n 
B 2 140 ALA 140 140 140 ALA ALA C . n 
B 2 141 GLY 141 141 141 GLY GLY C . n 
B 2 142 HIS 142 142 142 HIS HIS C . n 
B 2 143 THR 143 143 143 THR THR C . n 
B 2 144 GLY 144 144 144 GLY GLY C . n 
B 2 145 TYR 145 145 145 TYR TYR C . n 
B 2 146 LEU 146 146 146 LEU LEU C . n 
B 2 147 SER 147 147 147 SER SER C . n 
B 2 148 CYS 148 148 148 CYS CYS C . n 
B 2 149 CYS 149 149 149 CYS CYS C . n 
B 2 150 ARG 150 150 150 ARG ARG C . n 
B 2 151 PHE 151 151 151 PHE PHE C . n 
B 2 152 LEU 152 152 152 LEU LEU C . n 
B 2 153 ASP 153 153 153 ASP ASP C . n 
B 2 154 ASP 154 154 154 ASP ASP C . n 
B 2 155 ASN 155 155 155 ASN ASN C . n 
B 2 156 GLN 156 156 156 GLN GLN C . n 
B 2 157 ILE 157 157 157 ILE ILE C . n 
B 2 158 VAL 158 158 158 VAL VAL C . n 
B 2 159 THR 159 159 159 THR THR C . n 
B 2 160 SER 160 160 160 SER SER C . n 
B 2 161 SER 161 161 161 SER SER C . n 
B 2 162 GLY 162 162 162 GLY GLY C . n 
B 2 163 ASP 163 163 163 ASP ASP C . n 
B 2 164 THR 164 164 164 THR THR C . n 
B 2 165 THR 165 165 165 THR THR C . n 
B 2 166 CYS 166 166 166 CYS CYS C . n 
B 2 167 ALA 167 167 167 ALA ALA C . n 
B 2 168 LEU 168 168 168 LEU LEU C . n 
B 2 169 TRP 169 169 169 TRP TRP C . n 
B 2 170 ASP 170 170 170 ASP ASP C . n 
B 2 171 ILE 171 171 171 ILE ILE C . n 
B 2 172 GLU 172 172 172 GLU GLU C . n 
B 2 173 THR 173 173 173 THR THR C . n 
B 2 174 GLY 174 174 174 GLY GLY C . n 
B 2 175 GLN 175 175 175 GLN GLN C . n 
B 2 176 GLN 176 176 176 GLN GLN C . n 
B 2 177 THR 177 177 177 THR THR C . n 
B 2 178 THR 178 178 178 THR THR C . n 
B 2 179 THR 179 179 179 THR THR C . n 
B 2 180 PHE 180 180 180 PHE PHE C . n 
B 2 181 THR 181 181 181 THR THR C . n 
B 2 182 GLY 182 182 182 GLY GLY C . n 
B 2 183 HIS 183 183 183 HIS HIS C . n 
B 2 184 THR 184 184 184 THR THR C . n 
B 2 185 GLY 185 185 185 GLY GLY C . n 
B 2 186 ASP 186 186 186 ASP ASP C . n 
B 2 187 VAL 187 187 187 VAL VAL C . n 
B 2 188 MET 188 188 188 MET MET C . n 
B 2 189 SER 189 189 189 SER SER C . n 
B 2 190 LEU 190 190 190 LEU LEU C . n 
B 2 191 SER 191 191 191 SER SER C . n 
B 2 192 LEU 192 192 192 LEU LEU C . n 
B 2 193 ALA 193 193 193 ALA ALA C . n 
B 2 194 PRO 194 194 194 PRO PRO C . n 
B 2 195 ASP 195 195 195 ASP ASP C . n 
B 2 196 THR 196 196 196 THR THR C . n 
B 2 197 ARG 197 197 197 ARG ARG C . n 
B 2 198 LEU 198 198 198 LEU LEU C . n 
B 2 199 PHE 199 199 199 PHE PHE C . n 
B 2 200 VAL 200 200 200 VAL VAL C . n 
B 2 201 SER 201 201 201 SER SER C . n 
B 2 202 GLY 202 202 202 GLY GLY C . n 
B 2 203 ALA 203 203 203 ALA ALA C . n 
B 2 204 CYS 204 204 204 CYS CYS C . n 
B 2 205 ASP 205 205 205 ASP ASP C . n 
B 2 206 ALA 206 206 206 ALA ALA C . n 
B 2 207 SER 207 207 207 SER SER C . n 
B 2 208 ALA 208 208 208 ALA ALA C . n 
B 2 209 LYS 209 209 209 LYS LYS C . n 
B 2 210 LEU 210 210 210 LEU LEU C . n 
B 2 211 TRP 211 211 211 TRP TRP C . n 
B 2 212 ASP 212 212 212 ASP ASP C . n 
B 2 213 VAL 213 213 213 VAL VAL C . n 
B 2 214 ARG 214 214 214 ARG ARG C . n 
B 2 215 GLU 215 215 215 GLU GLU C . n 
B 2 216 GLY 216 216 216 GLY GLY C . n 
B 2 217 MET 217 217 217 MET MET C . n 
B 2 218 CYS 218 218 218 CYS CYS C . n 
B 2 219 ARG 219 219 219 ARG ARG C . n 
B 2 220 GLN 220 220 220 GLN GLN C . n 
B 2 221 THR 221 221 221 THR THR C . n 
B 2 222 PHE 222 222 222 PHE PHE C . n 
B 2 223 THR 223 223 223 THR THR C . n 
B 2 224 GLY 224 224 224 GLY GLY C . n 
B 2 225 HIS 225 225 225 HIS HIS C . n 
B 2 226 GLU 226 226 226 GLU GLU C . n 
B 2 227 SER 227 227 227 SER SER C . n 
B 2 228 ASP 228 228 228 ASP ASP C . n 
B 2 229 ILE 229 229 229 ILE ILE C . n 
B 2 230 ASN 230 230 230 ASN ASN C . n 
B 2 231 ALA 231 231 231 ALA ALA C . n 
B 2 232 ILE 232 232 232 ILE ILE C . n 
B 2 233 CYS 233 233 233 CYS CYS C . n 
B 2 234 PHE 234 234 234 PHE PHE C . n 
B 2 235 PHE 235 235 235 PHE PHE C . n 
B 2 236 PRO 236 236 236 PRO PRO C . n 
B 2 237 ASN 237 237 237 ASN ASN C . n 
B 2 238 GLY 238 238 238 GLY GLY C . n 
B 2 239 ASN 239 239 239 ASN ASN C . n 
B 2 240 ALA 240 240 240 ALA ALA C . n 
B 2 241 PHE 241 241 241 PHE PHE C . n 
B 2 242 ALA 242 242 242 ALA ALA C . n 
B 2 243 THR 243 243 243 THR THR C . n 
B 2 244 GLY 244 244 244 GLY GLY C . n 
B 2 245 SER 245 245 245 SER SER C . n 
B 2 246 ASP 246 246 246 ASP ASP C . n 
B 2 247 ASP 247 247 247 ASP ASP C . n 
B 2 248 ALA 248 248 248 ALA ALA C . n 
B 2 249 THR 249 249 249 THR THR C . n 
B 2 250 CYS 250 250 250 CYS CYS C . n 
B 2 251 ARG 251 251 251 ARG ARG C . n 
B 2 252 LEU 252 252 252 LEU LEU C . n 
B 2 253 PHE 253 253 253 PHE PHE C . n 
B 2 254 ASP 254 254 254 ASP ASP C . n 
B 2 255 LEU 255 255 255 LEU LEU C . n 
B 2 256 ARG 256 256 256 ARG ARG C . n 
B 2 257 ALA 257 257 257 ALA ALA C . n 
B 2 258 ASP 258 258 258 ASP ASP C . n 
B 2 259 GLN 259 259 259 GLN GLN C . n 
B 2 260 GLU 260 260 260 GLU GLU C . n 
B 2 261 LEU 261 261 261 LEU LEU C . n 
B 2 262 MET 262 262 262 MET MET C . n 
B 2 263 THR 263 263 263 THR THR C . n 
B 2 264 TYR 264 264 264 TYR TYR C . n 
B 2 265 SER 265 265 265 SER SER C . n 
B 2 266 HIS 266 266 266 HIS HIS C . n 
B 2 267 ASP 267 267 267 ASP ASP C . n 
B 2 268 ASN 268 268 268 ASN ASN C . n 
B 2 269 ILE 269 269 269 ILE ILE C . n 
B 2 270 ILE 270 270 270 ILE ILE C . n 
B 2 271 CYS 271 271 271 CYS CYS C . n 
B 2 272 GLY 272 272 272 GLY GLY C . n 
B 2 273 ILE 273 273 273 ILE ILE C . n 
B 2 274 THR 274 274 274 THR THR C . n 
B 2 275 SER 275 275 275 SER SER C . n 
B 2 276 VAL 276 276 276 VAL VAL C . n 
B 2 277 SER 277 277 277 SER SER C . n 
B 2 278 PHE 278 278 278 PHE PHE C . n 
B 2 279 SER 279 279 279 SER SER C . n 
B 2 280 LYS 280 280 280 LYS LYS C . n 
B 2 281 SER 281 281 281 SER SER C . n 
B 2 282 GLY 282 282 282 GLY GLY C . n 
B 2 283 ARG 283 283 283 ARG ARG C . n 
B 2 284 LEU 284 284 284 LEU LEU C . n 
B 2 285 LEU 285 285 285 LEU LEU C . n 
B 2 286 LEU 286 286 286 LEU LEU C . n 
B 2 287 ALA 287 287 287 ALA ALA C . n 
B 2 288 GLY 288 288 288 GLY GLY C . n 
B 2 289 TYR 289 289 289 TYR TYR C . n 
B 2 290 ASP 290 290 290 ASP ASP C . n 
B 2 291 ASP 291 291 291 ASP ASP C . n 
B 2 292 PHE 292 292 292 PHE PHE C . n 
B 2 293 ASN 293 293 293 ASN ASN C . n 
B 2 294 CYS 294 294 294 CYS CYS C . n 
B 2 295 ASN 295 295 295 ASN ASN C . n 
B 2 296 VAL 296 296 296 VAL VAL C . n 
B 2 297 TRP 297 297 297 TRP TRP C . n 
B 2 298 ASP 298 298 298 ASP ASP C . n 
B 2 299 ALA 299 299 299 ALA ALA C . n 
B 2 300 LEU 300 300 300 LEU LEU C . n 
B 2 301 LYS 301 301 301 LYS LYS C . n 
B 2 302 ALA 302 302 302 ALA ALA C . n 
B 2 303 ASP 303 303 303 ASP ASP C . n 
B 2 304 ARG 304 304 304 ARG ARG C . n 
B 2 305 ALA 305 305 305 ALA ALA C . n 
B 2 306 GLY 306 306 306 GLY GLY C . n 
B 2 307 VAL 307 307 307 VAL VAL C . n 
B 2 308 LEU 308 308 308 LEU LEU C . n 
B 2 309 ALA 309 309 309 ALA ALA C . n 
B 2 310 GLY 310 310 310 GLY GLY C . n 
B 2 311 HIS 311 311 311 HIS HIS C . n 
B 2 312 ASP 312 312 312 ASP ASP C . n 
B 2 313 ASN 313 313 313 ASN ASN C . n 
B 2 314 ARG 314 314 314 ARG ARG C . n 
B 2 315 VAL 315 315 315 VAL VAL C . n 
B 2 316 SER 316 316 316 SER SER C . n 
B 2 317 CYS 317 317 317 CYS CYS C . n 
B 2 318 LEU 318 318 318 LEU LEU C . n 
B 2 319 GLY 319 319 319 GLY GLY C . n 
B 2 320 VAL 320 320 320 VAL VAL C . n 
B 2 321 THR 321 321 321 THR THR C . n 
B 2 322 ASP 322 322 322 ASP ASP C . n 
B 2 323 ASP 323 323 323 ASP ASP C . n 
B 2 324 GLY 324 324 324 GLY GLY C . n 
B 2 325 MET 325 325 325 MET MET C . n 
B 2 326 ALA 326 326 326 ALA ALA C . n 
B 2 327 VAL 327 327 327 VAL VAL C . n 
B 2 328 ALA 328 328 328 ALA ALA C . n 
B 2 329 THR 329 329 329 THR THR C . n 
B 2 330 GLY 330 330 330 GLY GLY C . n 
B 2 331 SER 331 331 331 SER SER C . n 
B 2 332 TRP 332 332 332 TRP TRP C . n 
B 2 333 ASP 333 333 333 ASP ASP C . n 
B 2 334 SER 334 334 334 SER SER C . n 
B 2 335 PHE 335 335 335 PHE PHE C . n 
B 2 336 LEU 336 336 336 LEU LEU C . n 
B 2 337 LYS 337 337 337 LYS LYS C . n 
B 2 338 ILE 338 338 338 ILE ILE C . n 
B 2 339 TRP 339 339 339 TRP TRP C . n 
B 2 340 ASN 340 340 340 ASN ASN C . n 
C 3 1   MET 1   1   ?   ?   ?   D . n 
C 3 2   ALA 2   2   ?   ?   ?   D . n 
C 3 3   SER 3   3   ?   ?   ?   D . n 
C 3 4   ASN 4   4   ?   ?   ?   D . n 
C 3 5   ASN 5   5   ?   ?   ?   D . n 
C 3 6   THR 6   6   ?   ?   ?   D . n 
C 3 7   ALA 7   7   ?   ?   ?   D . n 
C 3 8   SER 8   8   8   SER SER D . n 
C 3 9   ILE 9   9   9   ILE ILE D . n 
C 3 10  ALA 10  10  10  ALA ALA D . n 
C 3 11  GLN 11  11  11  GLN GLN D . n 
C 3 12  ALA 12  12  12  ALA ALA D . n 
C 3 13  ARG 13  13  13  ARG ARG D . n 
C 3 14  LYS 14  14  14  LYS LYS D . n 
C 3 15  LEU 15  15  15  LEU LEU D . n 
C 3 16  VAL 16  16  16  VAL VAL D . n 
C 3 17  GLU 17  17  17  GLU GLU D . n 
C 3 18  GLN 18  18  18  GLN GLN D . n 
C 3 19  LEU 19  19  19  LEU LEU D . n 
C 3 20  LYS 20  20  20  LYS LYS D . n 
C 3 21  MET 21  21  21  MET MET D . n 
C 3 22  GLU 22  22  22  GLU GLU D . n 
C 3 23  ALA 23  23  23  ALA ALA D . n 
C 3 24  ASN 24  24  24  ASN ASN D . n 
C 3 25  ILE 25  25  25  ILE ILE D . n 
C 3 26  ASP 26  26  26  ASP ASP D . n 
C 3 27  ARG 27  27  27  ARG ARG D . n 
C 3 28  ILE 28  28  28  ILE ILE D . n 
C 3 29  LYS 29  29  29  LYS LYS D . n 
C 3 30  VAL 30  30  30  VAL VAL D . n 
C 3 31  SER 31  31  31  SER SER D . n 
C 3 32  LYS 32  32  32  LYS LYS D . n 
C 3 33  ALA 33  33  33  ALA ALA D . n 
C 3 34  ALA 34  34  34  ALA ALA D . n 
C 3 35  ALA 35  35  35  ALA ALA D . n 
C 3 36  ASP 36  36  36  ASP ASP D . n 
C 3 37  LEU 37  37  37  LEU LEU D . n 
C 3 38  MET 38  38  38  MET MET D . n 
C 3 39  ALA 39  39  39  ALA ALA D . n 
C 3 40  TYR 40  40  40  TYR TYR D . n 
C 3 41  CYS 41  41  41  CYS CYS D . n 
C 3 42  GLU 42  42  42  GLU GLU D . n 
C 3 43  ALA 43  43  43  ALA ALA D . n 
C 3 44  HIS 44  44  44  HIS HIS D . n 
C 3 45  ALA 45  45  45  ALA ALA D . n 
C 3 46  LYS 46  46  46  LYS LYS D . n 
C 3 47  GLU 47  47  47  GLU GLU D . n 
C 3 48  ASP 48  48  48  ASP ASP D . n 
C 3 49  PRO 49  49  49  PRO PRO D . n 
C 3 50  LEU 50  50  50  LEU LEU D . n 
C 3 51  LEU 51  51  51  LEU LEU D . n 
C 3 52  THR 52  52  52  THR THR D . n 
C 3 53  PRO 53  53  53  PRO PRO D . n 
C 3 54  VAL 54  54  54  VAL VAL D . n 
C 3 55  PRO 55  55  55  PRO PRO D . n 
C 3 56  ALA 56  56  56  ALA ALA D . n 
C 3 57  SER 57  57  57  SER SER D . n 
C 3 58  GLU 58  58  58  GLU GLU D . n 
C 3 59  ASN 59  59  59  ASN ASN D . n 
C 3 60  PRO 60  60  60  PRO PRO D . n 
C 3 61  PHE 61  61  61  PHE PHE D . n 
C 3 62  ARG 62  62  62  ARG ARG D . n 
C 3 63  GLU 63  63  ?   ?   ?   D . n 
C 3 64  LYS 64  64  ?   ?   ?   D . n 
C 3 65  LYS 65  65  ?   ?   ?   D . n 
C 3 66  PHE 66  66  ?   ?   ?   D . n 
C 3 67  PHE 67  67  ?   ?   ?   D . n 
C 3 68  CYS 68  68  ?   ?   ?   D . n 
C 3 69  ALA 69  69  ?   ?   ?   D . n 
C 3 70  ILE 70  70  ?   ?   ?   D . n 
C 3 71  LEU 71  71  ?   ?   ?   D . n 
D 4 1   MET 1   1   ?   ?   ?   B . n 
D 4 2   GLY 2   2   ?   ?   ?   B . n 
D 4 3   CYS 3   3   ?   ?   ?   B . n 
D 4 4   THR 4   4   ?   ?   ?   B . n 
D 4 5   LEU 5   5   5   LEU LEU B . n 
D 4 6   SER 6   6   6   SER SER B . n 
D 4 7   ALA 7   7   7   ALA ALA B . n 
D 4 8   GLU 8   8   8   GLU GLU B . n 
D 4 9   ASP 9   9   9   ASP ASP B . n 
D 4 10  LYS 10  10  10  LYS LYS B . n 
D 4 11  ALA 11  11  11  ALA ALA B . n 
D 4 12  ALA 12  12  12  ALA ALA B . n 
D 4 13  VAL 13  13  13  VAL VAL B . n 
D 4 14  GLU 14  14  14  GLU GLU B . n 
D 4 15  ARG 15  15  15  ARG ARG B . n 
D 4 16  SER 16  16  16  SER SER B . n 
D 4 17  LYS 17  17  17  LYS LYS B . n 
D 4 18  MET 18  18  18  MET MET B . n 
D 4 19  ILE 19  19  19  ILE ILE B . n 
D 4 20  ASP 20  20  20  ASP ASP B . n 
D 4 21  ARG 21  21  21  ARG ARG B . n 
D 4 22  ASN 22  22  22  ASN ASN B . n 
D 4 23  LEU 23  23  23  LEU LEU B . n 
D 4 24  ARG 24  24  24  ARG ARG B . n 
D 4 25  GLU 25  25  25  GLU GLU B . n 
D 4 26  ASP 26  26  26  ASP ASP B . n 
D 4 27  GLY 27  27  27  GLY GLY B . n 
D 4 28  GLU 28  28  28  GLU GLU B . n 
D 4 29  LYS 29  29  29  LYS LYS B . n 
D 4 30  ALA 30  30  30  ALA ALA B . n 
D 4 31  ALA 31  31  31  ALA ALA B . n 
D 4 32  ARG 32  32  32  ARG ARG B . n 
D 4 33  GLU 33  33  33  GLU GLU B . n 
D 4 34  VAL 34  34  34  VAL VAL B . n 
D 4 35  LYS 35  35  35  LYS LYS B . n 
D 4 36  LEU 36  36  36  LEU LEU B . n 
D 4 37  LEU 37  37  37  LEU LEU B . n 
D 4 38  LEU 38  38  38  LEU LEU B . n 
D 4 39  LEU 39  39  39  LEU LEU B . n 
D 4 40  GLY 40  40  40  GLY GLY B . n 
D 4 41  ALA 41  41  41  ALA ALA B . n 
D 4 42  GLY 42  42  42  GLY GLY B . n 
D 4 43  GLU 43  43  43  GLU GLU B . n 
D 4 44  SER 44  44  44  SER SER B . n 
D 4 45  GLY 45  45  45  GLY GLY B . n 
D 4 46  LYS 46  46  46  LYS LYS B . n 
D 4 47  SER 47  47  47  SER SER B . n 
D 4 48  THR 48  48  48  THR THR B . n 
D 4 49  ILE 49  49  49  ILE ILE B . n 
D 4 50  VAL 50  50  50  VAL VAL B . n 
D 4 51  LYS 51  51  51  LYS LYS B . n 
D 4 52  GLN 52  52  52  GLN GLN B . n 
D 4 53  MET 53  53  ?   ?   ?   B . n 
D 4 54  LYS 54  54  ?   ?   ?   B . n 
D 4 55  ILE 55  55  ?   ?   ?   B . n 
D 4 56  ILE 56  56  ?   ?   ?   B . n 
D 4 57  HIS 57  57  ?   ?   ?   B . n 
D 4 58  GLU 58  58  ?   ?   ?   B . n 
D 4 59  ALA 59  59  ?   ?   ?   B . n 
D 4 60  GLY 60  60  ?   ?   ?   B . n 
D 4 61  TYR 61  61  ?   ?   ?   B . n 
D 4 62  SER 62  62  ?   ?   ?   B . n 
D 4 63  GLU 63  63  ?   ?   ?   B . n 
D 4 64  GLU 64  64  ?   ?   ?   B . n 
D 4 65  GLU 65  65  ?   ?   ?   B . n 
D 4 66  CYS 66  66  ?   ?   ?   B . n 
D 4 67  LYS 67  67  ?   ?   ?   B . n 
D 4 68  GLN 68  68  ?   ?   ?   B . n 
D 4 69  TYR 69  69  ?   ?   ?   B . n 
D 4 70  LYS 70  70  ?   ?   ?   B . n 
D 4 71  ALA 71  71  ?   ?   ?   B . n 
D 4 72  VAL 72  72  ?   ?   ?   B . n 
D 4 73  VAL 73  73  ?   ?   ?   B . n 
D 4 74  TYR 74  74  ?   ?   ?   B . n 
D 4 75  SER 75  75  ?   ?   ?   B . n 
D 4 76  ASN 76  76  ?   ?   ?   B . n 
D 4 77  THR 77  77  ?   ?   ?   B . n 
D 4 78  ILE 78  78  ?   ?   ?   B . n 
D 4 79  GLN 79  79  ?   ?   ?   B . n 
D 4 80  SER 80  80  ?   ?   ?   B . n 
D 4 81  ILE 81  81  ?   ?   ?   B . n 
D 4 82  ILE 82  82  ?   ?   ?   B . n 
D 4 83  ALA 83  83  ?   ?   ?   B . n 
D 4 84  ILE 84  84  ?   ?   ?   B . n 
D 4 85  ILE 85  85  ?   ?   ?   B . n 
D 4 86  ARG 86  86  ?   ?   ?   B . n 
D 4 87  ALA 87  87  ?   ?   ?   B . n 
D 4 88  MET 88  88  ?   ?   ?   B . n 
D 4 89  GLY 89  89  ?   ?   ?   B . n 
D 4 90  ARG 90  90  ?   ?   ?   B . n 
D 4 91  LEU 91  91  ?   ?   ?   B . n 
D 4 92  LYS 92  92  ?   ?   ?   B . n 
D 4 93  ILE 93  93  ?   ?   ?   B . n 
D 4 94  ASP 94  94  ?   ?   ?   B . n 
D 4 95  PHE 95  95  ?   ?   ?   B . n 
D 4 96  GLY 96  96  ?   ?   ?   B . n 
D 4 97  ASP 97  97  ?   ?   ?   B . n 
D 4 98  SER 98  98  ?   ?   ?   B . n 
D 4 99  ALA 99  99  ?   ?   ?   B . n 
D 4 100 ARG 100 100 ?   ?   ?   B . n 
D 4 101 ALA 101 101 ?   ?   ?   B . n 
D 4 102 ASP 102 102 ?   ?   ?   B . n 
D 4 103 ASP 103 103 ?   ?   ?   B . n 
D 4 104 ALA 104 104 ?   ?   ?   B . n 
D 4 105 ARG 105 105 ?   ?   ?   B . n 
D 4 106 GLN 106 106 ?   ?   ?   B . n 
D 4 107 LEU 107 107 ?   ?   ?   B . n 
D 4 108 PHE 108 108 ?   ?   ?   B . n 
D 4 109 VAL 109 109 ?   ?   ?   B . n 
D 4 110 LEU 110 110 ?   ?   ?   B . n 
D 4 111 ALA 111 111 ?   ?   ?   B . n 
D 4 112 GLY 112 112 ?   ?   ?   B . n 
D 4 113 ALA 113 113 ?   ?   ?   B . n 
D 4 114 ALA 114 114 ?   ?   ?   B . n 
D 4 115 GLU 115 115 ?   ?   ?   B . n 
D 4 116 GLU 116 116 ?   ?   ?   B . n 
D 4 117 GLY 117 117 ?   ?   ?   B . n 
D 4 118 PHE 118 118 ?   ?   ?   B . n 
D 4 119 MET 119 119 ?   ?   ?   B . n 
D 4 120 THR 120 120 ?   ?   ?   B . n 
D 4 121 ALA 121 121 ?   ?   ?   B . n 
D 4 122 GLU 122 122 ?   ?   ?   B . n 
D 4 123 LEU 123 123 ?   ?   ?   B . n 
D 4 124 ALA 124 124 ?   ?   ?   B . n 
D 4 125 GLY 125 125 ?   ?   ?   B . n 
D 4 126 VAL 126 126 ?   ?   ?   B . n 
D 4 127 ILE 127 127 ?   ?   ?   B . n 
D 4 128 LYS 128 128 ?   ?   ?   B . n 
D 4 129 ARG 129 129 ?   ?   ?   B . n 
D 4 130 LEU 130 130 ?   ?   ?   B . n 
D 4 131 TRP 131 131 ?   ?   ?   B . n 
D 4 132 LYS 132 132 ?   ?   ?   B . n 
D 4 133 ASP 133 133 ?   ?   ?   B . n 
D 4 134 SER 134 134 ?   ?   ?   B . n 
D 4 135 GLY 135 135 ?   ?   ?   B . n 
D 4 136 VAL 136 136 ?   ?   ?   B . n 
D 4 137 GLN 137 137 ?   ?   ?   B . n 
D 4 138 ALA 138 138 ?   ?   ?   B . n 
D 4 139 CYS 139 139 ?   ?   ?   B . n 
D 4 140 PHE 140 140 ?   ?   ?   B . n 
D 4 141 ASN 141 141 ?   ?   ?   B . n 
D 4 142 ARG 142 142 ?   ?   ?   B . n 
D 4 143 SER 143 143 ?   ?   ?   B . n 
D 4 144 ARG 144 144 ?   ?   ?   B . n 
D 4 145 GLU 145 145 ?   ?   ?   B . n 
D 4 146 TYR 146 146 ?   ?   ?   B . n 
D 4 147 GLN 147 147 ?   ?   ?   B . n 
D 4 148 LEU 148 148 ?   ?   ?   B . n 
D 4 149 ASN 149 149 ?   ?   ?   B . n 
D 4 150 ASP 150 150 ?   ?   ?   B . n 
D 4 151 SER 151 151 ?   ?   ?   B . n 
D 4 152 ALA 152 152 ?   ?   ?   B . n 
D 4 153 ALA 153 153 ?   ?   ?   B . n 
D 4 154 TYR 154 154 ?   ?   ?   B . n 
D 4 155 TYR 155 155 ?   ?   ?   B . n 
D 4 156 LEU 156 156 ?   ?   ?   B . n 
D 4 157 ASN 157 157 ?   ?   ?   B . n 
D 4 158 ASP 158 158 ?   ?   ?   B . n 
D 4 159 LEU 159 159 ?   ?   ?   B . n 
D 4 160 ASP 160 160 ?   ?   ?   B . n 
D 4 161 ARG 161 161 ?   ?   ?   B . n 
D 4 162 ILE 162 162 ?   ?   ?   B . n 
D 4 163 ALA 163 163 ?   ?   ?   B . n 
D 4 164 GLN 164 164 ?   ?   ?   B . n 
D 4 165 PRO 165 165 ?   ?   ?   B . n 
D 4 166 ASN 166 166 ?   ?   ?   B . n 
D 4 167 TYR 167 167 ?   ?   ?   B . n 
D 4 168 ILE 168 168 ?   ?   ?   B . n 
D 4 169 PRO 169 169 ?   ?   ?   B . n 
D 4 170 THR 170 170 ?   ?   ?   B . n 
D 4 171 GLN 171 171 ?   ?   ?   B . n 
D 4 172 GLN 172 172 ?   ?   ?   B . n 
D 4 173 ASP 173 173 ?   ?   ?   B . n 
D 4 174 VAL 174 174 ?   ?   ?   B . n 
D 4 175 LEU 175 175 ?   ?   ?   B . n 
D 4 176 ARG 176 176 ?   ?   ?   B . n 
D 4 177 THR 177 177 ?   ?   ?   B . n 
D 4 178 ARG 178 178 ?   ?   ?   B . n 
D 4 179 VAL 179 179 ?   ?   ?   B . n 
D 4 180 LYS 180 180 180 LYS LYS B . n 
D 4 181 THR 181 181 181 THR THR B . n 
D 4 182 THR 182 182 182 THR THR B . n 
D 4 183 GLY 183 183 183 GLY GLY B . n 
D 4 184 ILE 184 184 184 ILE ILE B . n 
D 4 185 VAL 185 185 185 VAL VAL B . n 
D 4 186 GLU 186 186 186 GLU GLU B . n 
D 4 187 THR 187 187 187 THR THR B . n 
D 4 188 HIS 188 188 188 HIS HIS B . n 
D 4 189 PHE 189 189 189 PHE PHE B . n 
D 4 190 THR 190 190 190 THR THR B . n 
D 4 191 PHE 191 191 191 PHE PHE B . n 
D 4 192 LYS 192 192 192 LYS LYS B . n 
D 4 193 ASP 193 193 193 ASP ASP B . n 
D 4 194 LEU 194 194 194 LEU LEU B . n 
D 4 195 HIS 195 195 195 HIS HIS B . n 
D 4 196 PHE 196 196 196 PHE PHE B . n 
D 4 197 LYS 197 197 197 LYS LYS B . n 
D 4 198 MET 198 198 198 MET MET B . n 
D 4 199 PHE 199 199 199 PHE PHE B . n 
D 4 200 ASP 200 200 200 ASP ASP B . n 
D 4 201 VAL 201 201 201 VAL VAL B . n 
D 4 202 GLY 202 202 202 GLY GLY B . n 
D 4 203 GLY 203 203 203 GLY ALA B . n 
D 4 204 GLN 204 204 204 GLN GLN B . n 
D 4 205 ARG 205 205 205 ARG ARG B . n 
D 4 206 SER 206 206 206 SER SER B . n 
D 4 207 GLU 207 207 207 GLU GLU B . n 
D 4 208 ARG 208 208 208 ARG ARG B . n 
D 4 209 LYS 209 209 209 LYS LYS B . n 
D 4 210 LYS 210 210 210 LYS LYS B . n 
D 4 211 TRP 211 211 211 TRP TRP B . n 
D 4 212 ILE 212 212 212 ILE ILE B . n 
D 4 213 HIS 213 213 213 HIS HIS B . n 
D 4 214 CYS 214 214 214 CYS CYS B . n 
D 4 215 PHE 215 215 215 PHE PHE B . n 
D 4 216 GLU 216 216 216 GLU GLU B . n 
D 4 217 GLY 217 217 217 GLY GLY B . n 
D 4 218 VAL 218 218 218 VAL VAL B . n 
D 4 219 THR 219 219 219 THR THR B . n 
D 4 220 ALA 220 220 220 ALA ALA B . n 
D 4 221 ILE 221 221 221 ILE ILE B . n 
D 4 222 ILE 222 222 222 ILE ILE B . n 
D 4 223 PHE 223 223 223 PHE PHE B . n 
D 4 224 CYS 224 224 224 CYS CYS B . n 
D 4 225 VAL 225 225 225 VAL VAL B . n 
D 4 226 ALA 226 226 226 ALA ALA B . n 
D 4 227 LEU 227 227 227 LEU LEU B . n 
D 4 228 SER 228 228 228 SER SER B . n 
D 4 229 ASP 229 229 229 ASP ASP B . n 
D 4 230 TYR 230 230 230 TYR TYR B . n 
D 4 231 ASP 231 231 231 ASP ASP B . n 
D 4 232 LEU 232 232 232 LEU LEU B . n 
D 4 233 VAL 233 233 233 VAL VAL B . n 
D 4 234 LEU 234 234 234 LEU LEU B . n 
D 4 235 ALA 235 235 235 ALA ALA B . n 
D 4 236 GLU 236 236 236 GLU GLU B . n 
D 4 237 ASP 237 237 237 ASP ASP B . n 
D 4 238 GLU 238 238 238 GLU GLU B . n 
D 4 239 GLU 239 239 239 GLU GLU B . n 
D 4 240 MET 240 240 240 MET MET B . n 
D 4 241 ASN 241 241 241 ASN ASN B . n 
D 4 242 ARG 242 242 242 ARG ARG B . n 
D 4 243 MET 243 243 243 MET MET B . n 
D 4 244 HIS 244 244 244 HIS HIS B . n 
D 4 245 GLU 245 245 245 GLU GLU B . n 
D 4 246 SER 246 246 246 SER SER B . n 
D 4 247 MET 247 247 247 MET MET B . n 
D 4 248 LYS 248 248 248 LYS LYS B . n 
D 4 249 LEU 249 249 249 LEU LEU B . n 
D 4 250 PHE 250 250 250 PHE PHE B . n 
D 4 251 ASP 251 251 251 ASP ASP B . n 
D 4 252 SER 252 252 252 SER SER B . n 
D 4 253 ILE 253 253 253 ILE ILE B . n 
D 4 254 CYS 254 254 254 CYS CYS B . n 
D 4 255 ASN 255 255 255 ASN ASN B . n 
D 4 256 ASN 256 256 256 ASN ASN B . n 
D 4 257 LYS 257 257 257 LYS LYS B . n 
D 4 258 TRP 258 258 258 TRP TRP B . n 
D 4 259 PHE 259 259 259 PHE PHE B . n 
D 4 260 THR 260 260 260 THR THR B . n 
D 4 261 ASP 261 261 261 ASP ASP B . n 
D 4 262 THR 262 262 262 THR THR B . n 
D 4 263 SER 263 263 263 SER SER B . n 
D 4 264 ILE 264 264 264 ILE ILE B . n 
D 4 265 ILE 265 265 265 ILE ILE B . n 
D 4 266 LEU 266 266 266 LEU LEU B . n 
D 4 267 PHE 267 267 267 PHE PHE B . n 
D 4 268 LEU 268 268 268 LEU LEU B . n 
D 4 269 ASN 269 269 269 ASN ASN B . n 
D 4 270 LYS 270 270 270 LYS LYS B . n 
D 4 271 LYS 271 271 271 LYS LYS B . n 
D 4 272 ASP 272 272 272 ASP ASP B . n 
D 4 273 LEU 273 273 273 LEU LEU B . n 
D 4 274 PHE 274 274 274 PHE PHE B . n 
D 4 275 GLU 275 275 275 GLU GLU B . n 
D 4 276 GLU 276 276 276 GLU GLU B . n 
D 4 277 LYS 277 277 277 LYS LYS B . n 
D 4 278 ILE 278 278 278 ILE ILE B . n 
D 4 279 LYS 279 279 279 LYS LYS B . n 
D 4 280 LYS 280 280 280 LYS LYS B . n 
D 4 281 SER 281 281 281 SER SER B . n 
D 4 282 PRO 282 282 282 PRO PRO B . n 
D 4 283 LEU 283 283 283 LEU LEU B . n 
D 4 284 THR 284 284 284 THR THR B . n 
D 4 285 ILE 285 285 285 ILE ILE B . n 
D 4 286 CYS 286 286 286 CYS CYS B . n 
D 4 287 TYR 287 287 287 TYR TYR B . n 
D 4 288 PRO 288 288 288 PRO PRO B . n 
D 4 289 GLU 289 289 289 GLU GLU B . n 
D 4 290 TYR 290 290 290 TYR TYR B . n 
D 4 291 ALA 291 291 291 ALA ALA B . n 
D 4 292 GLY 292 292 292 GLY GLY B . n 
D 4 293 SER 293 293 293 SER SER B . n 
D 4 294 ASN 294 294 294 ASN ASN B . n 
D 4 295 THR 295 295 295 THR THR B . n 
D 4 296 TYR 296 296 296 TYR TYR B . n 
D 4 297 GLU 297 297 297 GLU GLU B . n 
D 4 298 GLU 298 298 298 GLU GLU B . n 
D 4 299 ALA 299 299 299 ALA ALA B . n 
D 4 300 ALA 300 300 300 ALA ALA B . n 
D 4 301 ALA 301 301 301 ALA ALA B . n 
D 4 302 TYR 302 302 302 TYR TYR B . n 
D 4 303 ILE 303 303 303 ILE ILE B . n 
D 4 304 GLN 304 304 304 GLN GLN B . n 
D 4 305 CYS 305 305 305 CYS CYS B . n 
D 4 306 GLN 306 306 306 GLN GLN B . n 
D 4 307 PHE 307 307 307 PHE PHE B . n 
D 4 308 GLU 308 308 308 GLU GLU B . n 
D 4 309 ASP 309 309 309 ASP ASP B . n 
D 4 310 LEU 310 310 310 LEU LEU B . n 
D 4 311 ASN 311 311 311 ASN ASN B . n 
D 4 312 LYS 312 312 312 LYS LYS B . n 
D 4 313 ARG 313 313 313 ARG ARG B . n 
D 4 314 LYS 314 314 314 LYS LYS B . n 
D 4 315 ASP 315 315 315 ASP ASP B . n 
D 4 316 THR 316 316 316 THR THR B . n 
D 4 317 LYS 317 317 317 LYS LYS B . n 
D 4 318 GLU 318 318 318 GLU GLU B . n 
D 4 319 ILE 319 319 319 ILE ILE B . n 
D 4 320 TYR 320 320 320 TYR TYR B . n 
D 4 321 THR 321 321 321 THR THR B . n 
D 4 322 HIS 322 322 322 HIS HIS B . n 
D 4 323 PHE 323 323 323 PHE PHE B . n 
D 4 324 THR 324 324 324 THR THR B . n 
D 4 325 CYS 325 325 325 CYS CYS B . n 
D 4 326 ALA 326 326 326 ALA ALA B . n 
D 4 327 THR 327 327 327 THR THR B . n 
D 4 328 ASP 328 328 328 ASP ASP B . n 
D 4 329 THR 329 329 329 THR THR B . n 
D 4 330 LYS 330 330 330 LYS LYS B . n 
D 4 331 ASN 331 331 331 ASN ASN B . n 
D 4 332 VAL 332 332 332 VAL VAL B . n 
D 4 333 GLN 333 333 333 GLN GLN B . n 
D 4 334 PHE 334 334 334 PHE PHE B . n 
D 4 335 VAL 335 335 335 VAL VAL B . n 
D 4 336 PHE 336 336 336 PHE PHE B . n 
D 4 337 ASP 337 337 337 ASP ASP B . n 
D 4 338 ALA 338 338 338 ALA ALA B . n 
D 4 339 VAL 339 339 339 VAL VAL B . n 
D 4 340 THR 340 340 340 THR THR B . n 
D 4 341 ASP 341 341 341 ASP ASP B . n 
D 4 342 VAL 342 342 342 VAL VAL B . n 
D 4 343 ILE 343 343 343 ILE ILE B . n 
D 4 344 ILE 344 344 344 ILE ILE B . n 
D 4 345 LYS 345 345 345 LYS LYS B . n 
D 4 346 ASN 346 346 346 ASN ASN B . n 
D 4 347 ASN 347 347 347 ASN ASN B . n 
D 4 348 LEU 348 348 348 LEU LEU B . n 
D 4 349 LYS 349 349 349 LYS LYS B . n 
D 4 350 ASP 350 350 350 ASP ASP B . n 
D 4 351 CYS 351 351 351 CYS CYS B . n 
D 4 352 GLY 352 352 352 GLY GLY B . n 
D 4 353 LEU 353 353 353 LEU LEU B . n 
D 4 354 PHE 354 354 354 PHE PHE B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        JDC 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   JDC 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
_pdbx_nonpoly_scheme.asym_id         E 
_pdbx_nonpoly_scheme.entity_id       5 
_pdbx_nonpoly_scheme.mon_id          JDC 
_pdbx_nonpoly_scheme.ndb_seq_num     1 
_pdbx_nonpoly_scheme.pdb_seq_num     401 
_pdbx_nonpoly_scheme.auth_seq_num    1 
_pdbx_nonpoly_scheme.pdb_mon_id      JDC 
_pdbx_nonpoly_scheme.auth_mon_id     JDC 
_pdbx_nonpoly_scheme.pdb_strand_id   A 
_pdbx_nonpoly_scheme.pdb_ins_code    . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A PHE 82  ? CG  ? A PHE 82  CG  
2   1 Y 1 A PHE 82  ? CD1 ? A PHE 82  CD1 
3   1 Y 1 A PHE 82  ? CD2 ? A PHE 82  CD2 
4   1 Y 1 A PHE 82  ? CE1 ? A PHE 82  CE1 
5   1 Y 1 A PHE 82  ? CE2 ? A PHE 82  CE2 
6   1 Y 1 A PHE 82  ? CZ  ? A PHE 82  CZ  
7   1 Y 1 A ILE 85  ? CG1 ? A ILE 85  CG1 
8   1 Y 1 A ILE 85  ? CG2 ? A ILE 85  CG2 
9   1 Y 1 A ILE 85  ? CD1 ? A ILE 85  CD1 
10  1 Y 1 A ARG 86  ? CG  ? A ARG 86  CG  
11  1 Y 1 A ARG 86  ? CD  ? A ARG 86  CD  
12  1 Y 1 A ARG 86  ? NE  ? A ARG 86  NE  
13  1 Y 1 A ARG 86  ? CZ  ? A ARG 86  CZ  
14  1 Y 1 A ARG 86  ? NH1 ? A ARG 86  NH1 
15  1 Y 1 A ARG 86  ? NH2 ? A ARG 86  NH2 
16  1 Y 1 A TYR 87  ? CG  ? A TYR 87  CG  
17  1 Y 1 A TYR 87  ? CD1 ? A TYR 87  CD1 
18  1 Y 1 A TYR 87  ? CD2 ? A TYR 87  CD2 
19  1 Y 1 A TYR 87  ? CE1 ? A TYR 87  CE1 
20  1 Y 1 A TYR 87  ? CE2 ? A TYR 87  CE2 
21  1 Y 1 A TYR 87  ? CZ  ? A TYR 87  CZ  
22  1 Y 1 A TYR 87  ? OH  ? A TYR 87  OH  
23  1 Y 1 A LYS 89  ? CG  ? A LYS 89  CG  
24  1 Y 1 A LYS 89  ? CD  ? A LYS 89  CD  
25  1 Y 1 A LYS 89  ? CE  ? A LYS 89  CE  
26  1 Y 1 A LYS 89  ? NZ  ? A LYS 89  NZ  
27  1 Y 1 A LYS 91  ? CG  ? A LYS 91  CG  
28  1 Y 1 A LYS 91  ? CD  ? A LYS 91  CD  
29  1 Y 1 A LYS 91  ? CE  ? A LYS 91  CE  
30  1 Y 1 A LYS 91  ? NZ  ? A LYS 91  NZ  
31  1 Y 1 A MET 112 ? CG  ? A MET 112 CG  
32  1 Y 1 A MET 112 ? SD  ? A MET 112 SD  
33  1 Y 1 A MET 112 ? CE  ? A MET 112 CE  
34  1 Y 1 A GLU 203 ? CG  ? A GLU 203 CG  
35  1 Y 1 A GLU 203 ? CD  ? A GLU 203 CD  
36  1 Y 1 A GLU 203 ? OE1 ? A GLU 203 OE1 
37  1 Y 1 A GLU 203 ? OE2 ? A GLU 203 OE2 
38  1 Y 1 A GLN 213 ? CG  ? A GLN 213 CG  
39  1 Y 1 A GLN 213 ? CD  ? A GLN 213 CD  
40  1 Y 1 A GLN 213 ? OE1 ? A GLN 213 OE1 
41  1 Y 1 A GLN 213 ? NE2 ? A GLN 213 NE2 
42  1 Y 1 A PHE 214 ? CG  ? A PHE 214 CG  
43  1 Y 1 A PHE 214 ? CD1 ? A PHE 214 CD1 
44  1 Y 1 A PHE 214 ? CD2 ? A PHE 214 CD2 
45  1 Y 1 A PHE 214 ? CE1 ? A PHE 214 CE1 
46  1 Y 1 A PHE 214 ? CE2 ? A PHE 214 CE2 
47  1 Y 1 A PHE 214 ? CZ  ? A PHE 214 CZ  
48  1 Y 1 A ASP 216 ? CG  ? A ASP 216 CG  
49  1 Y 1 A ASP 216 ? OD1 ? A ASP 216 OD1 
50  1 Y 1 A ASP 216 ? OD2 ? A ASP 216 OD2 
51  1 Y 1 A ASP 217 ? CG  ? A ASP 217 CG  
52  1 Y 1 A ASP 217 ? OD1 ? A ASP 217 OD1 
53  1 Y 1 A ASP 217 ? OD2 ? A ASP 217 OD2 
54  1 Y 1 A ASP 218 ? CG  ? A ASP 218 CG  
55  1 Y 1 A ASP 218 ? OD1 ? A ASP 218 OD1 
56  1 Y 1 A ASP 218 ? OD2 ? A ASP 218 OD2 
57  1 Y 1 A TYR 219 ? CG  ? A TYR 219 CG  
58  1 Y 1 A TYR 219 ? CD1 ? A TYR 219 CD1 
59  1 Y 1 A TYR 219 ? CD2 ? A TYR 219 CD2 
60  1 Y 1 A TYR 219 ? CE1 ? A TYR 219 CE1 
61  1 Y 1 A TYR 219 ? CE2 ? A TYR 219 CE2 
62  1 Y 1 A TYR 219 ? CZ  ? A TYR 219 CZ  
63  1 Y 1 A TYR 219 ? OH  ? A TYR 219 OH  
64  1 Y 1 A SER 220 ? OG  ? A SER 220 OG  
65  1 Y 1 A TRP 221 ? CG  ? A TRP 221 CG  
66  1 Y 1 A TRP 221 ? CD1 ? A TRP 221 CD1 
67  1 Y 1 A TRP 221 ? CD2 ? A TRP 221 CD2 
68  1 Y 1 A TRP 221 ? NE1 ? A TRP 221 NE1 
69  1 Y 1 A TRP 221 ? CE2 ? A TRP 221 CE2 
70  1 Y 1 A TRP 221 ? CE3 ? A TRP 221 CE3 
71  1 Y 1 A TRP 221 ? CZ2 ? A TRP 221 CZ2 
72  1 Y 1 A TRP 221 ? CZ3 ? A TRP 221 CZ3 
73  1 Y 1 A TRP 221 ? CH2 ? A TRP 221 CH2 
74  1 Y 1 A TRP 222 ? CG  ? A TRP 222 CG  
75  1 Y 1 A TRP 222 ? CD1 ? A TRP 222 CD1 
76  1 Y 1 A TRP 222 ? CD2 ? A TRP 222 CD2 
77  1 Y 1 A TRP 222 ? NE1 ? A TRP 222 NE1 
78  1 Y 1 A TRP 222 ? CE2 ? A TRP 222 CE2 
79  1 Y 1 A TRP 222 ? CE3 ? A TRP 222 CE3 
80  1 Y 1 A TRP 222 ? CZ2 ? A TRP 222 CZ2 
81  1 Y 1 A TRP 222 ? CZ3 ? A TRP 222 CZ3 
82  1 Y 1 A TRP 222 ? CH2 ? A TRP 222 CH2 
83  1 Y 1 A ARG 263 ? CG  ? A ARG 263 CG  
84  1 Y 1 A ARG 263 ? CD  ? A ARG 263 CD  
85  1 Y 1 A ARG 263 ? NE  ? A ARG 263 NE  
86  1 Y 1 A ARG 263 ? CZ  ? A ARG 263 CZ  
87  1 Y 1 A ARG 263 ? NH1 ? A ARG 263 NH1 
88  1 Y 1 A ARG 263 ? NH2 ? A ARG 263 NH2 
89  1 Y 1 A VAL 296 ? CG1 ? A VAL 296 CG1 
90  1 Y 1 A VAL 296 ? CG2 ? A VAL 296 CG2 
91  1 Y 1 A GLU 297 ? CG  ? A GLU 297 CG  
92  1 Y 1 A GLU 297 ? CD  ? A GLU 297 CD  
93  1 Y 1 A GLU 297 ? OE1 ? A GLU 297 OE1 
94  1 Y 1 A GLU 297 ? OE2 ? A GLU 297 OE2 
95  1 Y 1 A SER 301 ? OG  ? A SER 301 OG  
96  1 Y 1 A THR 302 ? OG1 ? A THR 302 OG1 
97  1 Y 1 A THR 302 ? CG2 ? A THR 302 CG2 
98  1 Y 1 A SER 303 ? OG  ? A SER 303 OG  
99  1 Y 1 A HIS 304 ? CG  ? A HIS 304 CG  
100 1 Y 1 A HIS 304 ? ND1 ? A HIS 304 ND1 
101 1 Y 1 A HIS 304 ? CD2 ? A HIS 304 CD2 
102 1 Y 1 A HIS 304 ? CE1 ? A HIS 304 CE1 
103 1 Y 1 A HIS 304 ? NE2 ? A HIS 304 NE2 
104 1 Y 1 A SER 305 ? OG  ? A SER 305 OG  
105 1 Y 1 A SER 311 ? OG  ? A SER 311 OG  
106 1 Y 1 A ILE 328 ? CG1 ? A ILE 328 CG1 
107 1 Y 1 A ILE 328 ? CG2 ? A ILE 328 CG2 
108 1 Y 1 A ILE 328 ? CD1 ? A ILE 328 CD1 
109 1 Y 1 A PHE 332 ? CG  ? A PHE 332 CG  
110 1 Y 1 A PHE 332 ? CD1 ? A PHE 332 CD1 
111 1 Y 1 A PHE 332 ? CD2 ? A PHE 332 CD2 
112 1 Y 1 A PHE 332 ? CE1 ? A PHE 332 CE1 
113 1 Y 1 A PHE 332 ? CE2 ? A PHE 332 CE2 
114 1 Y 1 A PHE 332 ? CZ  ? A PHE 332 CZ  
115 1 Y 1 A ARG 339 ? CG  ? A ARG 339 CG  
116 1 Y 1 A ARG 339 ? CD  ? A ARG 339 CD  
117 1 Y 1 A ARG 339 ? NE  ? A ARG 339 NE  
118 1 Y 1 A ARG 339 ? CZ  ? A ARG 339 CZ  
119 1 Y 1 A ARG 339 ? NH1 ? A ARG 339 NH1 
120 1 Y 1 A ARG 339 ? NH2 ? A ARG 339 NH2 
121 1 Y 1 A PHE 341 ? CG  ? A PHE 341 CG  
122 1 Y 1 A PHE 341 ? CD1 ? A PHE 341 CD1 
123 1 Y 1 A PHE 341 ? CD2 ? A PHE 341 CD2 
124 1 Y 1 A PHE 341 ? CE1 ? A PHE 341 CE1 
125 1 Y 1 A PHE 341 ? CE2 ? A PHE 341 CE2 
126 1 Y 1 A PHE 341 ? CZ  ? A PHE 341 CZ  
127 1 Y 1 A ARG 342 ? CG  ? A ARG 342 CG  
128 1 Y 1 A ARG 342 ? CD  ? A ARG 342 CD  
129 1 Y 1 A ARG 342 ? NE  ? A ARG 342 NE  
130 1 Y 1 A ARG 342 ? CZ  ? A ARG 342 CZ  
131 1 Y 1 A ARG 342 ? NH1 ? A ARG 342 NH1 
132 1 Y 1 A ARG 342 ? NH2 ? A ARG 342 NH2 
133 1 Y 1 C ASP 5   ? CG  ? B ASP 5   CG  
134 1 Y 1 C ASP 5   ? OD1 ? B ASP 5   OD1 
135 1 Y 1 C ASP 5   ? OD2 ? B ASP 5   OD2 
136 1 Y 1 C ARG 8   ? CG  ? B ARG 8   CG  
137 1 Y 1 C ARG 8   ? CD  ? B ARG 8   CD  
138 1 Y 1 C ARG 8   ? NE  ? B ARG 8   NE  
139 1 Y 1 C ARG 8   ? CZ  ? B ARG 8   CZ  
140 1 Y 1 C ARG 8   ? NH1 ? B ARG 8   NH1 
141 1 Y 1 C ARG 8   ? NH2 ? B ARG 8   NH2 
142 1 Y 1 C LYS 15  ? CG  ? B LYS 15  CG  
143 1 Y 1 C LYS 15  ? CD  ? B LYS 15  CD  
144 1 Y 1 C LYS 15  ? CE  ? B LYS 15  CE  
145 1 Y 1 C LYS 15  ? NZ  ? B LYS 15  NZ  
146 1 Y 1 C ARG 42  ? CG  ? B ARG 42  CG  
147 1 Y 1 C ARG 42  ? CD  ? B ARG 42  CD  
148 1 Y 1 C ARG 42  ? NE  ? B ARG 42  NE  
149 1 Y 1 C ARG 42  ? CZ  ? B ARG 42  CZ  
150 1 Y 1 C ARG 42  ? NH1 ? B ARG 42  NH1 
151 1 Y 1 C ARG 42  ? NH2 ? B ARG 42  NH2 
152 1 Y 1 C ILE 43  ? CG1 ? B ILE 43  CG1 
153 1 Y 1 C ILE 43  ? CG2 ? B ILE 43  CG2 
154 1 Y 1 C ILE 43  ? CD1 ? B ILE 43  CD1 
155 1 Y 1 C GLN 44  ? CG  ? B GLN 44  CG  
156 1 Y 1 C GLN 44  ? CD  ? B GLN 44  CD  
157 1 Y 1 C GLN 44  ? OE1 ? B GLN 44  OE1 
158 1 Y 1 C GLN 44  ? NE2 ? B GLN 44  NE2 
159 1 Y 1 C ARG 129 ? CG  ? B ARG 129 CG  
160 1 Y 1 C ARG 129 ? CD  ? B ARG 129 CD  
161 1 Y 1 C ARG 129 ? NE  ? B ARG 129 NE  
162 1 Y 1 C ARG 129 ? CZ  ? B ARG 129 CZ  
163 1 Y 1 C ARG 129 ? NH1 ? B ARG 129 NH1 
164 1 Y 1 C ARG 129 ? NH2 ? B ARG 129 NH2 
165 1 Y 1 C ASN 268 ? CG  ? B ASN 268 CG  
166 1 Y 1 C ASN 268 ? OD1 ? B ASN 268 OD1 
167 1 Y 1 C ASN 268 ? ND2 ? B ASN 268 ND2 
168 1 Y 1 C ASN 295 ? CG  ? B ASN 295 CG  
169 1 Y 1 C ASN 295 ? OD1 ? B ASN 295 OD1 
170 1 Y 1 C ASN 295 ? ND2 ? B ASN 295 ND2 
171 1 Y 1 D GLN 11  ? CG  ? C GLN 11  CG  
172 1 Y 1 D GLN 11  ? CD  ? C GLN 11  CD  
173 1 Y 1 D GLN 11  ? OE1 ? C GLN 11  OE1 
174 1 Y 1 D GLN 11  ? NE2 ? C GLN 11  NE2 
175 1 Y 1 D LYS 14  ? CG  ? C LYS 14  CG  
176 1 Y 1 D LYS 14  ? CD  ? C LYS 14  CD  
177 1 Y 1 D LYS 14  ? CE  ? C LYS 14  CE  
178 1 Y 1 D LYS 14  ? NZ  ? C LYS 14  NZ  
179 1 Y 1 D LYS 20  ? CG  ? C LYS 20  CG  
180 1 Y 1 D LYS 20  ? CD  ? C LYS 20  CD  
181 1 Y 1 D LYS 20  ? CE  ? C LYS 20  CE  
182 1 Y 1 D LYS 20  ? NZ  ? C LYS 20  NZ  
183 1 Y 1 D GLU 47  ? CG  ? C GLU 47  CG  
184 1 Y 1 D GLU 47  ? CD  ? C GLU 47  CD  
185 1 Y 1 D GLU 47  ? OE1 ? C GLU 47  OE1 
186 1 Y 1 D GLU 47  ? OE2 ? C GLU 47  OE2 
187 1 Y 1 D VAL 54  ? CG1 ? C VAL 54  CG1 
188 1 Y 1 D VAL 54  ? CG2 ? C VAL 54  CG2 
189 1 Y 1 D SER 57  ? OG  ? C SER 57  OG  
190 1 Y 1 D GLU 58  ? CG  ? C GLU 58  CG  
191 1 Y 1 D GLU 58  ? CD  ? C GLU 58  CD  
192 1 Y 1 D GLU 58  ? OE1 ? C GLU 58  OE1 
193 1 Y 1 D GLU 58  ? OE2 ? C GLU 58  OE2 
194 1 Y 1 D ARG 62  ? CG  ? C ARG 62  CG  
195 1 Y 1 D ARG 62  ? CD  ? C ARG 62  CD  
196 1 Y 1 D ARG 62  ? NE  ? C ARG 62  NE  
197 1 Y 1 D ARG 62  ? CZ  ? C ARG 62  CZ  
198 1 Y 1 D ARG 62  ? NH1 ? C ARG 62  NH1 
199 1 Y 1 D ARG 62  ? NH2 ? C ARG 62  NH2 
200 1 Y 1 B LYS 180 ? CG  ? D LYS 180 CG  
201 1 Y 1 B LYS 180 ? CD  ? D LYS 180 CD  
202 1 Y 1 B LYS 180 ? CE  ? D LYS 180 CE  
203 1 Y 1 B LYS 180 ? NZ  ? D LYS 180 NZ  
204 1 Y 1 B ARG 205 ? CG  ? D ARG 205 CG  
205 1 Y 1 B ARG 205 ? CD  ? D ARG 205 CD  
206 1 Y 1 B ARG 205 ? NE  ? D ARG 205 NE  
207 1 Y 1 B ARG 205 ? CZ  ? D ARG 205 CZ  
208 1 Y 1 B ARG 205 ? NH1 ? D ARG 205 NH1 
209 1 Y 1 B ARG 205 ? NH2 ? D ARG 205 NH2 
210 1 Y 1 B GLU 236 ? CG  ? D GLU 236 CG  
211 1 Y 1 B GLU 236 ? CD  ? D GLU 236 CD  
212 1 Y 1 B GLU 236 ? OE1 ? D GLU 236 OE1 
213 1 Y 1 B GLU 236 ? OE2 ? D GLU 236 OE2 
214 1 Y 1 B MET 240 ? CG  ? D MET 240 CG  
215 1 Y 1 B MET 240 ? SD  ? D MET 240 SD  
216 1 Y 1 B MET 240 ? CE  ? D MET 240 CE  
217 1 Y 1 B GLU 245 ? CG  ? D GLU 245 CG  
218 1 Y 1 B GLU 245 ? CD  ? D GLU 245 CD  
219 1 Y 1 B GLU 245 ? OE1 ? D GLU 245 OE1 
220 1 Y 1 B GLU 245 ? OE2 ? D GLU 245 OE2 
221 1 Y 1 B ASP 272 ? CG  ? D ASP 272 CG  
222 1 Y 1 B ASP 272 ? OD1 ? D ASP 272 OD1 
223 1 Y 1 B ASP 272 ? OD2 ? D ASP 272 OD2 
224 1 Y 1 B GLU 298 ? CG  ? D GLU 298 CG  
225 1 Y 1 B GLU 298 ? CD  ? D GLU 298 CD  
226 1 Y 1 B GLU 298 ? OE1 ? D GLU 298 OE1 
227 1 Y 1 B GLU 298 ? OE2 ? D GLU 298 OE2 
228 1 Y 1 B LYS 312 ? CG  ? D LYS 312 CG  
229 1 Y 1 B LYS 312 ? CD  ? D LYS 312 CD  
230 1 Y 1 B LYS 312 ? CE  ? D LYS 312 CE  
231 1 Y 1 B LYS 312 ? NZ  ? D LYS 312 NZ  
232 1 Y 1 B ARG 313 ? CG  ? D ARG 313 CG  
233 1 Y 1 B ARG 313 ? CD  ? D ARG 313 CD  
234 1 Y 1 B ARG 313 ? NE  ? D ARG 313 NE  
235 1 Y 1 B ARG 313 ? CZ  ? D ARG 313 CZ  
236 1 Y 1 B ARG 313 ? NH1 ? D ARG 313 NH1 
237 1 Y 1 B ARG 313 ? NH2 ? D ARG 313 NH2 
238 1 Y 1 B ASP 315 ? CG  ? D ASP 315 CG  
239 1 Y 1 B ASP 315 ? OD1 ? D ASP 315 OD1 
240 1 Y 1 B ASP 315 ? OD2 ? D ASP 315 OD2 
241 1 Y 1 B LYS 330 ? CG  ? D LYS 330 CG  
242 1 Y 1 B LYS 330 ? CD  ? D LYS 330 CD  
243 1 Y 1 B LYS 330 ? CE  ? D LYS 330 CE  
244 1 Y 1 B LYS 330 ? NZ  ? D LYS 330 NZ  
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9D61 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9D61 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9D61 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9D61 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            . 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004 ? 7024 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.711 ? 9548 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 6.163 ? 1002 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.048 ? 1138 ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 1199 ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9D61 
_struct.title                        'Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic , no scFv16' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9D61 
_struct_keywords.text            'G protein coupled receptor, Opioid receptor, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP OPRK_HUMAN  P41145 ? 1 
;MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLV
MFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAV
CHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGY
TNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
;
1 
2 UNP GBB1_HUMAN  P62873 ? 2 
;MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLI
IWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTS
SGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGV
TDDGMAVATGSWDSFLKIWN
;
1 
3 UNP GBG2_HUMAN  P59768 ? 3 MASNNTASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCAIL 1 
4 UNP GNAI1_HUMAN P63096 ? 4 
;MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQS
IIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD
RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY
THFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
;
1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9D61 A 1 ? 380 ? P41145 1 ? 380 ? 1 380 
2 2 9D61 C 1 ? 340 ? P62873 1 ? 340 ? 1 340 
3 3 9D61 D 1 ? 71  ? P59768 1 ? 71  ? 1 71  
4 4 9D61 B 1 ? 354 ? P63096 1 ? 354 ? 1 354 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 57  ? TYR A 87  ? ALA A 57  TYR A 87  1 ? 31 
HELX_P HELX_P2  AA2 THR A 92  ? THR A 110 ? THR A 92  THR A 110 1 ? 19 
HELX_P HELX_P3  AA3 THR A 111 ? ASN A 122 ? THR A 111 ASN A 122 1 ? 12 
HELX_P HELX_P4  AA4 PHE A 126 ? CYS A 161 ? PHE A 126 CYS A 161 1 ? 36 
HELX_P HELX_P5  AA5 HIS A 162 ? ARG A 170 ? HIS A 162 ARG A 170 1 ? 9  
HELX_P HELX_P6  AA6 THR A 171 ? LEU A 196 ? THR A 171 LEU A 196 1 ? 26 
HELX_P HELX_P7  AA7 TYR A 219 ? VAL A 236 ? TYR A 219 VAL A 236 1 ? 18 
HELX_P HELX_P8  AA8 VAL A 236 ? VAL A 256 ? VAL A 236 VAL A 256 1 ? 21 
HELX_P HELX_P9  AA9 GLU A 264 ? GLY A 300 ? GLU A 264 GLY A 300 1 ? 37 
HELX_P HELX_P10 AB1 SER A 305 ? LEU A 333 ? SER A 305 LEU A 333 1 ? 29 
HELX_P HELX_P11 AB2 GLU A 335 ? ARG A 342 ? GLU A 335 ARG A 342 1 ? 8  
HELX_P HELX_P12 AB3 GLU B 3   ? CYS B 25  ? GLU C 3   CYS C 25  1 ? 23 
HELX_P HELX_P13 AB4 LEU B 30  ? ASN B 35  ? LEU C 30  ASN C 35  1 ? 6  
HELX_P HELX_P14 AB5 ILE C 9   ? ASN C 24  ? ILE D 9   ASN D 24  1 ? 16 
HELX_P HELX_P15 AB6 LYS C 29  ? HIS C 44  ? LYS D 29  HIS D 44  1 ? 16 
HELX_P HELX_P16 AB7 SER D 6   ? GLU D 28  ? SER B 6   GLU B 28  1 ? 23 
HELX_P HELX_P17 AB8 GLU D 28  ? GLU D 33  ? GLU B 28  GLU B 33  1 ? 6  
HELX_P HELX_P18 AB9 GLY D 45  ? VAL D 50  ? GLY B 45  VAL B 50  1 ? 6  
HELX_P HELX_P19 AC1 GLU D 207 ? PHE D 215 ? GLU B 207 PHE B 215 5 ? 9  
HELX_P HELX_P20 AC2 ASN D 241 ? ASN D 255 ? ASN B 241 ASN B 255 1 ? 15 
HELX_P HELX_P21 AC3 ASN D 256 ? THR D 260 ? ASN B 256 THR B 260 5 ? 5  
HELX_P HELX_P22 AC4 LYS D 270 ? SER D 281 ? LYS B 270 SER B 281 1 ? 12 
HELX_P HELX_P23 AC5 THR D 295 ? ASP D 309 ? THR B 295 ASP B 309 1 ? 15 
HELX_P HELX_P24 AC6 LYS D 330 ? CYS D 351 ? LYS B 330 CYS B 351 1 ? 22 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            disulf1 
_struct_conn.conn_type_id                  disulf 
_struct_conn.pdbx_leaving_atom_flag        ? 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            131 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           A 
_struct_conn.ptnr2_label_comp_id           CYS 
_struct_conn.ptnr2_label_seq_id            210 
_struct_conn.ptnr2_label_atom_id           SG 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             131 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            CYS 
_struct_conn.ptnr2_auth_seq_id             210 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               2.033 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       131 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      210 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        131 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       210 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 4 ? 
AA3 ? 4 ? 
AA4 ? 4 ? 
AA5 ? 3 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? parallel      
AA9 2 3 ? parallel      
AA9 3 4 ? parallel      
AB1 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLY A 197 ? VAL A 201 ? GLY A 197 VAL A 201 
AA1 2 ILE A 208 ? LEU A 212 ? ILE A 208 LEU A 212 
AA2 1 THR B 47  ? THR B 50  ? THR C 47  THR C 50  
AA2 2 LEU B 336 ? TRP B 339 ? LEU C 336 TRP C 339 
AA2 3 VAL B 327 ? SER B 331 ? VAL C 327 SER C 331 
AA2 4 VAL B 315 ? VAL B 320 ? VAL C 315 VAL C 320 
AA3 1 ILE B 58  ? TRP B 63  ? ILE C 58  TRP C 63  
AA3 2 LEU B 69  ? SER B 74  ? LEU C 69  SER C 74  
AA3 3 LYS B 78  ? ASP B 83  ? LYS C 78  ASP C 83  
AA3 4 LYS B 89  ? PRO B 94  ? LYS C 89  PRO C 94  
AA4 1 THR B 102 ? TYR B 105 ? THR C 102 TYR C 105 
AA4 2 TYR B 111 ? GLY B 115 ? TYR C 111 GLY C 115 
AA4 3 ILE B 120 ? ASN B 125 ? ILE C 120 ASN C 125 
AA4 4 ARG B 134 ? ALA B 140 ? ARG C 134 ALA C 140 
AA5 1 GLN B 156 ? SER B 160 ? GLN C 156 SER C 160 
AA5 2 THR B 165 ? ASP B 170 ? THR C 165 ASP C 170 
AA5 3 GLN B 176 ? THR B 181 ? GLN C 176 THR C 181 
AA6 1 SER B 191 ? LEU B 192 ? SER C 191 LEU C 192 
AA6 2 LEU B 198 ? GLY B 202 ? LEU C 198 GLY C 202 
AA6 3 ALA B 208 ? ASP B 212 ? ALA C 208 ASP C 212 
AA6 4 CYS B 218 ? PHE B 222 ? CYS C 218 PHE C 222 
AA7 1 ILE B 229 ? PHE B 234 ? ILE C 229 PHE C 234 
AA7 2 ALA B 240 ? SER B 245 ? ALA C 240 SER C 245 
AA7 3 CYS B 250 ? ASP B 254 ? CYS C 250 ASP C 254 
AA7 4 MET B 262 ? TYR B 264 ? MET C 262 TYR C 264 
AA8 1 VAL B 276 ? PHE B 278 ? VAL C 276 PHE C 278 
AA8 2 LEU B 284 ? GLY B 288 ? LEU C 284 GLY C 288 
AA8 3 CYS B 294 ? ASP B 298 ? CYS C 294 ASP C 298 
AA8 4 ARG B 304 ? VAL B 307 ? ARG C 304 VAL C 307 
AA9 1 LEU D 37  ? GLY D 40  ? LEU B 37  GLY B 40  
AA9 2 ALA D 220 ? ALA D 226 ? ALA B 220 ALA B 226 
AA9 3 SER D 263 ? ASN D 269 ? SER B 263 ASN B 269 
AA9 4 TYR D 320 ? PHE D 323 ? TYR B 320 PHE B 323 
AB1 1 VAL D 185 ? PHE D 189 ? VAL B 185 PHE B 189 
AB1 2 PHE D 196 ? ASP D 200 ? PHE B 196 ASP B 200 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 198 ? N GLY A 198 O SER A 211 ? O SER A 211 
AA2 1 2 N ARG B 49  ? N ARG C 49  O ILE B 338 ? O ILE C 338 
AA2 2 3 O TRP B 339 ? O TRP C 339 N VAL B 327 ? N VAL C 327 
AA2 3 4 O GLY B 330 ? O GLY C 330 N CYS B 317 ? N CYS C 317 
AA3 1 2 N ALA B 60  ? N ALA C 60  O ALA B 73  ? O ALA C 73  
AA3 2 3 N LEU B 70  ? N LEU C 70  O TRP B 82  ? O TRP C 82  
AA3 3 4 N ILE B 81  ? N ILE C 81  O VAL B 90  ? O VAL C 90  
AA4 1 2 N ALA B 104 ? N ALA C 104 O ALA B 113 ? O ALA C 113 
AA4 2 3 N CYS B 114 ? N CYS C 114 O SER B 122 ? O SER C 122 
AA4 3 4 N ASN B 125 ? N ASN C 125 O ARG B 134 ? O ARG C 134 
AA5 1 2 N THR B 159 ? N THR C 159 O ALA B 167 ? O ALA C 167 
AA5 2 3 N CYS B 166 ? N CYS C 166 O PHE B 180 ? O PHE C 180 
AA6 1 2 N SER B 191 ? N SER C 191 O VAL B 200 ? O VAL C 200 
AA6 2 3 N PHE B 199 ? N PHE C 199 O TRP B 211 ? O TRP C 211 
AA6 3 4 N LEU B 210 ? N LEU C 210 O ARG B 219 ? O ARG C 219 
AA7 1 2 N ALA B 231 ? N ALA C 231 O GLY B 244 ? O GLY C 244 
AA7 2 3 N THR B 243 ? N THR C 243 O ARG B 251 ? O ARG C 251 
AA7 3 4 N CYS B 250 ? N CYS C 250 O TYR B 264 ? O TYR C 264 
AA8 1 2 N SER B 277 ? N SER C 277 O LEU B 286 ? O LEU C 286 
AA8 2 3 N LEU B 285 ? N LEU C 285 O TRP B 297 ? O TRP C 297 
AA8 3 4 N VAL B 296 ? N VAL C 296 O GLY B 306 ? O GLY C 306 
AA9 1 2 N LEU D 39  ? N LEU B 39  O ILE D 222 ? O ILE B 222 
AA9 2 3 N ILE D 221 ? N ILE B 221 O ILE D 265 ? O ILE B 265 
AA9 3 4 N ILE D 264 ? N ILE B 264 O TYR D 320 ? O TYR B 320 
AB1 1 2 N VAL D 185 ? N VAL B 185 O ASP D 200 ? O ASP B 200 
# 
_pdbx_entry_details.entry_id                   9D61 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 PRO A 125 ? ? -90.67  54.12   
2  1 GLU A 203 ? ? -91.22  50.34   
3  1 VAL A 236 ? ? -123.09 -64.05  
4  1 ARG A 263 ? ? -93.60  -63.26  
5  1 GLU A 297 ? ? -91.73  45.27   
6  1 GLU A 335 ? ? 70.65   -11.47  
7  1 ASN C 35  ? ? -65.40  4.21    
8  1 ARG C 68  ? ? 75.14   -11.43  
9  1 ASN C 132 ? ? -174.73 -179.75 
10 1 ASP C 246 ? ? -93.40  54.69   
11 1 LEU C 308 ? ? -92.55  57.18   
12 1 GLU D 47  ? ? -90.87  56.28   
13 1 ASN D 59  ? ? 57.71   72.27   
14 1 PHE D 61  ? ? -91.99  59.68   
15 1 SER B 44  ? ? -99.13  36.72   
16 1 HIS B 195 ? ? 60.14   66.87   
17 1 LYS B 270 ? ? 38.50   59.28   
18 1 PRO B 288 ? ? -84.57  36.27   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9D61 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9D61 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.58 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               355326 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 
'Kappa opioid receptor in complex with heterotrimeric G protein (Gai/b/g) and inverse agonist JDTic' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2, 3, 4' 
# 
_em_imaging.entry_id                        9D61 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             -15000 
_em_imaging.nominal_defocus_max             -25000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        105000 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             'COMA FREE' 
_em_imaging.c2_aperture_diameter            50.0 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   200 
_em_sample_support.grid_type        'UltrAuFoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9D61 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              90 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   298 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9D61 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET 1   ? A MET 1   
2   1 Y 1 A ASP 2   ? A ASP 2   
3   1 Y 1 A SER 3   ? A SER 3   
4   1 Y 1 A PRO 4   ? A PRO 4   
5   1 Y 1 A ILE 5   ? A ILE 5   
6   1 Y 1 A GLN 6   ? A GLN 6   
7   1 Y 1 A ILE 7   ? A ILE 7   
8   1 Y 1 A PHE 8   ? A PHE 8   
9   1 Y 1 A ARG 9   ? A ARG 9   
10  1 Y 1 A GLY 10  ? A GLY 10  
11  1 Y 1 A GLU 11  ? A GLU 11  
12  1 Y 1 A PRO 12  ? A PRO 12  
13  1 Y 1 A GLY 13  ? A GLY 13  
14  1 Y 1 A PRO 14  ? A PRO 14  
15  1 Y 1 A THR 15  ? A THR 15  
16  1 Y 1 A CYS 16  ? A CYS 16  
17  1 Y 1 A ALA 17  ? A ALA 17  
18  1 Y 1 A PRO 18  ? A PRO 18  
19  1 Y 1 A SER 19  ? A SER 19  
20  1 Y 1 A ALA 20  ? A ALA 20  
21  1 Y 1 A CYS 21  ? A CYS 21  
22  1 Y 1 A LEU 22  ? A LEU 22  
23  1 Y 1 A PRO 23  ? A PRO 23  
24  1 Y 1 A PRO 24  ? A PRO 24  
25  1 Y 1 A ASN 25  ? A ASN 25  
26  1 Y 1 A SER 26  ? A SER 26  
27  1 Y 1 A SER 27  ? A SER 27  
28  1 Y 1 A ALA 28  ? A ALA 28  
29  1 Y 1 A TRP 29  ? A TRP 29  
30  1 Y 1 A PHE 30  ? A PHE 30  
31  1 Y 1 A PRO 31  ? A PRO 31  
32  1 Y 1 A GLY 32  ? A GLY 32  
33  1 Y 1 A TRP 33  ? A TRP 33  
34  1 Y 1 A ALA 34  ? A ALA 34  
35  1 Y 1 A GLU 35  ? A GLU 35  
36  1 Y 1 A PRO 36  ? A PRO 36  
37  1 Y 1 A ASP 37  ? A ASP 37  
38  1 Y 1 A SER 38  ? A SER 38  
39  1 Y 1 A ASN 39  ? A ASN 39  
40  1 Y 1 A GLY 40  ? A GLY 40  
41  1 Y 1 A SER 41  ? A SER 41  
42  1 Y 1 A ALA 42  ? A ALA 42  
43  1 Y 1 A GLY 43  ? A GLY 43  
44  1 Y 1 A SER 44  ? A SER 44  
45  1 Y 1 A GLU 45  ? A GLU 45  
46  1 Y 1 A ASP 46  ? A ASP 46  
47  1 Y 1 A ALA 47  ? A ALA 47  
48  1 Y 1 A GLN 48  ? A GLN 48  
49  1 Y 1 A LEU 49  ? A LEU 49  
50  1 Y 1 A GLU 50  ? A GLU 50  
51  1 Y 1 A PRO 51  ? A PRO 51  
52  1 Y 1 A ALA 52  ? A ALA 52  
53  1 Y 1 A HIS 53  ? A HIS 53  
54  1 Y 1 A ILE 54  ? A ILE 54  
55  1 Y 1 A SER 55  ? A SER 55  
56  1 Y 1 A PRO 56  ? A PRO 56  
57  1 Y 1 A ASP 343 ? A ASP 343 
58  1 Y 1 A PHE 344 ? A PHE 344 
59  1 Y 1 A CYS 345 ? A CYS 345 
60  1 Y 1 A PHE 346 ? A PHE 346 
61  1 Y 1 A PRO 347 ? A PRO 347 
62  1 Y 1 A LEU 348 ? A LEU 348 
63  1 Y 1 A LYS 349 ? A LYS 349 
64  1 Y 1 A MET 350 ? A MET 350 
65  1 Y 1 A ARG 351 ? A ARG 351 
66  1 Y 1 A MET 352 ? A MET 352 
67  1 Y 1 A GLU 353 ? A GLU 353 
68  1 Y 1 A ARG 354 ? A ARG 354 
69  1 Y 1 A GLN 355 ? A GLN 355 
70  1 Y 1 A SER 356 ? A SER 356 
71  1 Y 1 A THR 357 ? A THR 357 
72  1 Y 1 A SER 358 ? A SER 358 
73  1 Y 1 A ARG 359 ? A ARG 359 
74  1 Y 1 A VAL 360 ? A VAL 360 
75  1 Y 1 A ARG 361 ? A ARG 361 
76  1 Y 1 A ASN 362 ? A ASN 362 
77  1 Y 1 A THR 363 ? A THR 363 
78  1 Y 1 A VAL 364 ? A VAL 364 
79  1 Y 1 A GLN 365 ? A GLN 365 
80  1 Y 1 A ASP 366 ? A ASP 366 
81  1 Y 1 A PRO 367 ? A PRO 367 
82  1 Y 1 A ALA 368 ? A ALA 368 
83  1 Y 1 A TYR 369 ? A TYR 369 
84  1 Y 1 A LEU 370 ? A LEU 370 
85  1 Y 1 A ARG 371 ? A ARG 371 
86  1 Y 1 A ASP 372 ? A ASP 372 
87  1 Y 1 A ILE 373 ? A ILE 373 
88  1 Y 1 A ASP 374 ? A ASP 374 
89  1 Y 1 A GLY 375 ? A GLY 375 
90  1 Y 1 A MET 376 ? A MET 376 
91  1 Y 1 A ASN 377 ? A ASN 377 
92  1 Y 1 A LYS 378 ? A LYS 378 
93  1 Y 1 A PRO 379 ? A PRO 379 
94  1 Y 1 A VAL 380 ? A VAL 380 
95  1 Y 1 C MET 1   ? B MET 1   
96  1 Y 1 D MET 1   ? C MET 1   
97  1 Y 1 D ALA 2   ? C ALA 2   
98  1 Y 1 D SER 3   ? C SER 3   
99  1 Y 1 D ASN 4   ? C ASN 4   
100 1 Y 1 D ASN 5   ? C ASN 5   
101 1 Y 1 D THR 6   ? C THR 6   
102 1 Y 1 D ALA 7   ? C ALA 7   
103 1 Y 1 D GLU 63  ? C GLU 63  
104 1 Y 1 D LYS 64  ? C LYS 64  
105 1 Y 1 D LYS 65  ? C LYS 65  
106 1 Y 1 D PHE 66  ? C PHE 66  
107 1 Y 1 D PHE 67  ? C PHE 67  
108 1 Y 1 D CYS 68  ? C CYS 68  
109 1 Y 1 D ALA 69  ? C ALA 69  
110 1 Y 1 D ILE 70  ? C ILE 70  
111 1 Y 1 D LEU 71  ? C LEU 71  
112 1 Y 1 B MET 1   ? D MET 1   
113 1 Y 1 B GLY 2   ? D GLY 2   
114 1 Y 1 B CYS 3   ? D CYS 3   
115 1 Y 1 B THR 4   ? D THR 4   
116 1 Y 1 B MET 53  ? D MET 53  
117 1 Y 1 B LYS 54  ? D LYS 54  
118 1 Y 1 B ILE 55  ? D ILE 55  
119 1 Y 1 B ILE 56  ? D ILE 56  
120 1 Y 1 B HIS 57  ? D HIS 57  
121 1 Y 1 B GLU 58  ? D GLU 58  
122 1 Y 1 B ALA 59  ? D ALA 59  
123 1 Y 1 B GLY 60  ? D GLY 60  
124 1 Y 1 B TYR 61  ? D TYR 61  
125 1 Y 1 B SER 62  ? D SER 62  
126 1 Y 1 B GLU 63  ? D GLU 63  
127 1 Y 1 B GLU 64  ? D GLU 64  
128 1 Y 1 B GLU 65  ? D GLU 65  
129 1 Y 1 B CYS 66  ? D CYS 66  
130 1 Y 1 B LYS 67  ? D LYS 67  
131 1 Y 1 B GLN 68  ? D GLN 68  
132 1 Y 1 B TYR 69  ? D TYR 69  
133 1 Y 1 B LYS 70  ? D LYS 70  
134 1 Y 1 B ALA 71  ? D ALA 71  
135 1 Y 1 B VAL 72  ? D VAL 72  
136 1 Y 1 B VAL 73  ? D VAL 73  
137 1 Y 1 B TYR 74  ? D TYR 74  
138 1 Y 1 B SER 75  ? D SER 75  
139 1 Y 1 B ASN 76  ? D ASN 76  
140 1 Y 1 B THR 77  ? D THR 77  
141 1 Y 1 B ILE 78  ? D ILE 78  
142 1 Y 1 B GLN 79  ? D GLN 79  
143 1 Y 1 B SER 80  ? D SER 80  
144 1 Y 1 B ILE 81  ? D ILE 81  
145 1 Y 1 B ILE 82  ? D ILE 82  
146 1 Y 1 B ALA 83  ? D ALA 83  
147 1 Y 1 B ILE 84  ? D ILE 84  
148 1 Y 1 B ILE 85  ? D ILE 85  
149 1 Y 1 B ARG 86  ? D ARG 86  
150 1 Y 1 B ALA 87  ? D ALA 87  
151 1 Y 1 B MET 88  ? D MET 88  
152 1 Y 1 B GLY 89  ? D GLY 89  
153 1 Y 1 B ARG 90  ? D ARG 90  
154 1 Y 1 B LEU 91  ? D LEU 91  
155 1 Y 1 B LYS 92  ? D LYS 92  
156 1 Y 1 B ILE 93  ? D ILE 93  
157 1 Y 1 B ASP 94  ? D ASP 94  
158 1 Y 1 B PHE 95  ? D PHE 95  
159 1 Y 1 B GLY 96  ? D GLY 96  
160 1 Y 1 B ASP 97  ? D ASP 97  
161 1 Y 1 B SER 98  ? D SER 98  
162 1 Y 1 B ALA 99  ? D ALA 99  
163 1 Y 1 B ARG 100 ? D ARG 100 
164 1 Y 1 B ALA 101 ? D ALA 101 
165 1 Y 1 B ASP 102 ? D ASP 102 
166 1 Y 1 B ASP 103 ? D ASP 103 
167 1 Y 1 B ALA 104 ? D ALA 104 
168 1 Y 1 B ARG 105 ? D ARG 105 
169 1 Y 1 B GLN 106 ? D GLN 106 
170 1 Y 1 B LEU 107 ? D LEU 107 
171 1 Y 1 B PHE 108 ? D PHE 108 
172 1 Y 1 B VAL 109 ? D VAL 109 
173 1 Y 1 B LEU 110 ? D LEU 110 
174 1 Y 1 B ALA 111 ? D ALA 111 
175 1 Y 1 B GLY 112 ? D GLY 112 
176 1 Y 1 B ALA 113 ? D ALA 113 
177 1 Y 1 B ALA 114 ? D ALA 114 
178 1 Y 1 B GLU 115 ? D GLU 115 
179 1 Y 1 B GLU 116 ? D GLU 116 
180 1 Y 1 B GLY 117 ? D GLY 117 
181 1 Y 1 B PHE 118 ? D PHE 118 
182 1 Y 1 B MET 119 ? D MET 119 
183 1 Y 1 B THR 120 ? D THR 120 
184 1 Y 1 B ALA 121 ? D ALA 121 
185 1 Y 1 B GLU 122 ? D GLU 122 
186 1 Y 1 B LEU 123 ? D LEU 123 
187 1 Y 1 B ALA 124 ? D ALA 124 
188 1 Y 1 B GLY 125 ? D GLY 125 
189 1 Y 1 B VAL 126 ? D VAL 126 
190 1 Y 1 B ILE 127 ? D ILE 127 
191 1 Y 1 B LYS 128 ? D LYS 128 
192 1 Y 1 B ARG 129 ? D ARG 129 
193 1 Y 1 B LEU 130 ? D LEU 130 
194 1 Y 1 B TRP 131 ? D TRP 131 
195 1 Y 1 B LYS 132 ? D LYS 132 
196 1 Y 1 B ASP 133 ? D ASP 133 
197 1 Y 1 B SER 134 ? D SER 134 
198 1 Y 1 B GLY 135 ? D GLY 135 
199 1 Y 1 B VAL 136 ? D VAL 136 
200 1 Y 1 B GLN 137 ? D GLN 137 
201 1 Y 1 B ALA 138 ? D ALA 138 
202 1 Y 1 B CYS 139 ? D CYS 139 
203 1 Y 1 B PHE 140 ? D PHE 140 
204 1 Y 1 B ASN 141 ? D ASN 141 
205 1 Y 1 B ARG 142 ? D ARG 142 
206 1 Y 1 B SER 143 ? D SER 143 
207 1 Y 1 B ARG 144 ? D ARG 144 
208 1 Y 1 B GLU 145 ? D GLU 145 
209 1 Y 1 B TYR 146 ? D TYR 146 
210 1 Y 1 B GLN 147 ? D GLN 147 
211 1 Y 1 B LEU 148 ? D LEU 148 
212 1 Y 1 B ASN 149 ? D ASN 149 
213 1 Y 1 B ASP 150 ? D ASP 150 
214 1 Y 1 B SER 151 ? D SER 151 
215 1 Y 1 B ALA 152 ? D ALA 152 
216 1 Y 1 B ALA 153 ? D ALA 153 
217 1 Y 1 B TYR 154 ? D TYR 154 
218 1 Y 1 B TYR 155 ? D TYR 155 
219 1 Y 1 B LEU 156 ? D LEU 156 
220 1 Y 1 B ASN 157 ? D ASN 157 
221 1 Y 1 B ASP 158 ? D ASP 158 
222 1 Y 1 B LEU 159 ? D LEU 159 
223 1 Y 1 B ASP 160 ? D ASP 160 
224 1 Y 1 B ARG 161 ? D ARG 161 
225 1 Y 1 B ILE 162 ? D ILE 162 
226 1 Y 1 B ALA 163 ? D ALA 163 
227 1 Y 1 B GLN 164 ? D GLN 164 
228 1 Y 1 B PRO 165 ? D PRO 165 
229 1 Y 1 B ASN 166 ? D ASN 166 
230 1 Y 1 B TYR 167 ? D TYR 167 
231 1 Y 1 B ILE 168 ? D ILE 168 
232 1 Y 1 B PRO 169 ? D PRO 169 
233 1 Y 1 B THR 170 ? D THR 170 
234 1 Y 1 B GLN 171 ? D GLN 171 
235 1 Y 1 B GLN 172 ? D GLN 172 
236 1 Y 1 B ASP 173 ? D ASP 173 
237 1 Y 1 B VAL 174 ? D VAL 174 
238 1 Y 1 B LEU 175 ? D LEU 175 
239 1 Y 1 B ARG 176 ? D ARG 176 
240 1 Y 1 B THR 177 ? D THR 177 
241 1 Y 1 B ARG 178 ? D ARG 178 
242 1 Y 1 B VAL 179 ? D VAL 179 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
JDC C1   C N N 180 
JDC N2   N N N 181 
JDC C3   C N R 182 
JDC C4   C N N 183 
JDC C4A  C Y N 184 
JDC C5   C Y N 185 
JDC C6   C Y N 186 
JDC C7   C Y N 187 
JDC O7   O N N 188 
JDC C8   C Y N 189 
JDC C8A  C Y N 190 
JDC C1A  C N N 191 
JDC O1   O N N 192 
JDC N2A  N N N 193 
JDC C2A  C N S 194 
JDC C3A  C N N 195 
JDC C3D  C N N 196 
JDC C3B  C N N 197 
JDC C4D  C N N 198 
JDC N11  N N N 199 
JDC C21  C N N 200 
JDC C31  C N R 201 
JDC C34  C N N 202 
JDC C41  C N R 203 
JDC C51  C N N 204 
JDC C61  C N N 205 
JDC C4E  C N N 206 
JDC C1C  C Y N 207 
JDC C2C  C Y N 208 
JDC C3C  C Y N 209 
JDC O3C  O N N 210 
JDC C4C  C Y N 211 
JDC C5C  C Y N 212 
JDC C6C  C Y N 213 
JDC H1   H N N 214 
JDC H2   H N N 215 
JDC H3   H N N 216 
JDC H5   H N N 217 
JDC H6   H N N 218 
JDC H7   H N N 219 
JDC H8   H N N 220 
JDC H9   H N N 221 
JDC H10  H N N 222 
JDC H11  H N N 223 
JDC H12  H N N 224 
JDC H13  H N N 225 
JDC H14  H N N 226 
JDC H15  H N N 227 
JDC H16  H N N 228 
JDC H17  H N N 229 
JDC H18  H N N 230 
JDC H19  H N N 231 
JDC H20  H N N 232 
JDC H21  H N N 233 
JDC H22  H N N 234 
JDC H24  H N N 235 
JDC H25  H N N 236 
JDC H26  H N N 237 
JDC H27  H N N 238 
JDC H28  H N N 239 
JDC H29  H N N 240 
JDC H30  H N N 241 
JDC H31  H N N 242 
JDC H32  H N N 243 
JDC H33  H N N 244 
JDC H34  H N N 245 
JDC H35  H N N 246 
JDC H36  H N N 247 
JDC H37  H N N 248 
JDC H38  H N N 249 
JDC H39  H N N 250 
JDC H40  H N N 251 
JDC H41  H N N 252 
LEU N    N N N 253 
LEU CA   C N S 254 
LEU C    C N N 255 
LEU O    O N N 256 
LEU CB   C N N 257 
LEU CG   C N N 258 
LEU CD1  C N N 259 
LEU CD2  C N N 260 
LEU OXT  O N N 261 
LEU H    H N N 262 
LEU H2   H N N 263 
LEU HA   H N N 264 
LEU HB2  H N N 265 
LEU HB3  H N N 266 
LEU HG   H N N 267 
LEU HD11 H N N 268 
LEU HD12 H N N 269 
LEU HD13 H N N 270 
LEU HD21 H N N 271 
LEU HD22 H N N 272 
LEU HD23 H N N 273 
LEU HXT  H N N 274 
LYS N    N N N 275 
LYS CA   C N S 276 
LYS C    C N N 277 
LYS O    O N N 278 
LYS CB   C N N 279 
LYS CG   C N N 280 
LYS CD   C N N 281 
LYS CE   C N N 282 
LYS NZ   N N N 283 
LYS OXT  O N N 284 
LYS H    H N N 285 
LYS H2   H N N 286 
LYS HA   H N N 287 
LYS HB2  H N N 288 
LYS HB3  H N N 289 
LYS HG2  H N N 290 
LYS HG3  H N N 291 
LYS HD2  H N N 292 
LYS HD3  H N N 293 
LYS HE2  H N N 294 
LYS HE3  H N N 295 
LYS HZ1  H N N 296 
LYS HZ2  H N N 297 
LYS HZ3  H N N 298 
LYS HXT  H N N 299 
MET N    N N N 300 
MET CA   C N S 301 
MET C    C N N 302 
MET O    O N N 303 
MET CB   C N N 304 
MET CG   C N N 305 
MET SD   S N N 306 
MET CE   C N N 307 
MET OXT  O N N 308 
MET H    H N N 309 
MET H2   H N N 310 
MET HA   H N N 311 
MET HB2  H N N 312 
MET HB3  H N N 313 
MET HG2  H N N 314 
MET HG3  H N N 315 
MET HE1  H N N 316 
MET HE2  H N N 317 
MET HE3  H N N 318 
MET HXT  H N N 319 
PHE N    N N N 320 
PHE CA   C N S 321 
PHE C    C N N 322 
PHE O    O N N 323 
PHE CB   C N N 324 
PHE CG   C Y N 325 
PHE CD1  C Y N 326 
PHE CD2  C Y N 327 
PHE CE1  C Y N 328 
PHE CE2  C Y N 329 
PHE CZ   C Y N 330 
PHE OXT  O N N 331 
PHE H    H N N 332 
PHE H2   H N N 333 
PHE HA   H N N 334 
PHE HB2  H N N 335 
PHE HB3  H N N 336 
PHE HD1  H N N 337 
PHE HD2  H N N 338 
PHE HE1  H N N 339 
PHE HE2  H N N 340 
PHE HZ   H N N 341 
PHE HXT  H N N 342 
PRO N    N N N 343 
PRO CA   C N S 344 
PRO C    C N N 345 
PRO O    O N N 346 
PRO CB   C N N 347 
PRO CG   C N N 348 
PRO CD   C N N 349 
PRO OXT  O N N 350 
PRO H    H N N 351 
PRO HA   H N N 352 
PRO HB2  H N N 353 
PRO HB3  H N N 354 
PRO HG2  H N N 355 
PRO HG3  H N N 356 
PRO HD2  H N N 357 
PRO HD3  H N N 358 
PRO HXT  H N N 359 
SER N    N N N 360 
SER CA   C N S 361 
SER C    C N N 362 
SER O    O N N 363 
SER CB   C N N 364 
SER OG   O N N 365 
SER OXT  O N N 366 
SER H    H N N 367 
SER H2   H N N 368 
SER HA   H N N 369 
SER HB2  H N N 370 
SER HB3  H N N 371 
SER HG   H N N 372 
SER HXT  H N N 373 
THR N    N N N 374 
THR CA   C N S 375 
THR C    C N N 376 
THR O    O N N 377 
THR CB   C N R 378 
THR OG1  O N N 379 
THR CG2  C N N 380 
THR OXT  O N N 381 
THR H    H N N 382 
THR H2   H N N 383 
THR HA   H N N 384 
THR HB   H N N 385 
THR HG1  H N N 386 
THR HG21 H N N 387 
THR HG22 H N N 388 
THR HG23 H N N 389 
THR HXT  H N N 390 
TRP N    N N N 391 
TRP CA   C N S 392 
TRP C    C N N 393 
TRP O    O N N 394 
TRP CB   C N N 395 
TRP CG   C Y N 396 
TRP CD1  C Y N 397 
TRP CD2  C Y N 398 
TRP NE1  N Y N 399 
TRP CE2  C Y N 400 
TRP CE3  C Y N 401 
TRP CZ2  C Y N 402 
TRP CZ3  C Y N 403 
TRP CH2  C Y N 404 
TRP OXT  O N N 405 
TRP H    H N N 406 
TRP H2   H N N 407 
TRP HA   H N N 408 
TRP HB2  H N N 409 
TRP HB3  H N N 410 
TRP HD1  H N N 411 
TRP HE1  H N N 412 
TRP HE3  H N N 413 
TRP HZ2  H N N 414 
TRP HZ3  H N N 415 
TRP HH2  H N N 416 
TRP HXT  H N N 417 
TYR N    N N N 418 
TYR CA   C N S 419 
TYR C    C N N 420 
TYR O    O N N 421 
TYR CB   C N N 422 
TYR CG   C Y N 423 
TYR CD1  C Y N 424 
TYR CD2  C Y N 425 
TYR CE1  C Y N 426 
TYR CE2  C Y N 427 
TYR CZ   C Y N 428 
TYR OH   O N N 429 
TYR OXT  O N N 430 
TYR H    H N N 431 
TYR H2   H N N 432 
TYR HA   H N N 433 
TYR HB2  H N N 434 
TYR HB3  H N N 435 
TYR HD1  H N N 436 
TYR HD2  H N N 437 
TYR HE1  H N N 438 
TYR HE2  H N N 439 
TYR HH   H N N 440 
TYR HXT  H N N 441 
VAL N    N N N 442 
VAL CA   C N S 443 
VAL C    C N N 444 
VAL O    O N N 445 
VAL CB   C N N 446 
VAL CG1  C N N 447 
VAL CG2  C N N 448 
VAL OXT  O N N 449 
VAL H    H N N 450 
VAL H2   H N N 451 
VAL HA   H N N 452 
VAL HB   H N N 453 
VAL HG11 H N N 454 
VAL HG12 H N N 455 
VAL HG13 H N N 456 
VAL HG21 H N N 457 
VAL HG22 H N N 458 
VAL HG23 H N N 459 
VAL HXT  H N N 460 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
JDC C3B C3A  sing N N 171 
JDC C3A C3D  sing N N 172 
JDC C3A C2A  sing N N 173 
JDC C4D C2A  sing N N 174 
JDC C4D N11  sing N N 175 
JDC C2A N2A  sing N N 176 
JDC N2A C1A  sing N N 177 
JDC C61 N11  sing N N 178 
JDC C61 C51  sing N N 179 
JDC N11 C21  sing N N 180 
JDC C1A C3   sing N N 181 
JDC C1A O1   doub N N 182 
JDC C3  C4   sing N N 183 
JDC C3  N2   sing N N 184 
JDC C4  C4A  sing N N 185 
JDC C5  C4A  doub Y N 186 
JDC C5  C6   sing Y N 187 
JDC C4A C8A  sing Y N 188 
JDC C21 C31  sing N N 189 
JDC C6  C7   doub Y N 190 
JDC C51 C41  sing N N 191 
JDC C8A C1   sing N N 192 
JDC C8A C8   doub Y N 193 
JDC N2  C1   sing N N 194 
JDC C7  C8   sing Y N 195 
JDC C7  O7   sing N N 196 
JDC C4E C41  sing N N 197 
JDC C41 C31  sing N N 198 
JDC C41 C1C  sing N N 199 
JDC C31 C34  sing N N 200 
JDC C1C C6C  doub Y N 201 
JDC C1C C2C  sing Y N 202 
JDC C6C C5C  sing Y N 203 
JDC C2C C3C  doub Y N 204 
JDC C5C C4C  doub Y N 205 
JDC C3C C4C  sing Y N 206 
JDC C3C O3C  sing N N 207 
JDC C1  H1   sing N N 208 
JDC C1  H2   sing N N 209 
JDC N2  H3   sing N N 210 
JDC C3  H5   sing N N 211 
JDC C4  H6   sing N N 212 
JDC C4  H7   sing N N 213 
JDC C5  H8   sing N N 214 
JDC C6  H9   sing N N 215 
JDC O7  H10  sing N N 216 
JDC C8  H11  sing N N 217 
JDC N2A H12  sing N N 218 
JDC C2A H13  sing N N 219 
JDC C3A H14  sing N N 220 
JDC C3D H15  sing N N 221 
JDC C3D H16  sing N N 222 
JDC C3D H17  sing N N 223 
JDC C3B H18  sing N N 224 
JDC C3B H19  sing N N 225 
JDC C3B H20  sing N N 226 
JDC C4D H21  sing N N 227 
JDC C4D H22  sing N N 228 
JDC C21 H24  sing N N 229 
JDC C21 H25  sing N N 230 
JDC C31 H26  sing N N 231 
JDC C34 H27  sing N N 232 
JDC C34 H28  sing N N 233 
JDC C34 H29  sing N N 234 
JDC C51 H30  sing N N 235 
JDC C51 H31  sing N N 236 
JDC C61 H32  sing N N 237 
JDC C61 H33  sing N N 238 
JDC C4E H34  sing N N 239 
JDC C4E H35  sing N N 240 
JDC C4E H36  sing N N 241 
JDC C2C H37  sing N N 242 
JDC O3C H38  sing N N 243 
JDC C4C H39  sing N N 244 
JDC C5C H40  sing N N 245 
JDC C6C H41  sing N N 246 
LEU N   CA   sing N N 247 
LEU N   H    sing N N 248 
LEU N   H2   sing N N 249 
LEU CA  C    sing N N 250 
LEU CA  CB   sing N N 251 
LEU CA  HA   sing N N 252 
LEU C   O    doub N N 253 
LEU C   OXT  sing N N 254 
LEU CB  CG   sing N N 255 
LEU CB  HB2  sing N N 256 
LEU CB  HB3  sing N N 257 
LEU CG  CD1  sing N N 258 
LEU CG  CD2  sing N N 259 
LEU CG  HG   sing N N 260 
LEU CD1 HD11 sing N N 261 
LEU CD1 HD12 sing N N 262 
LEU CD1 HD13 sing N N 263 
LEU CD2 HD21 sing N N 264 
LEU CD2 HD22 sing N N 265 
LEU CD2 HD23 sing N N 266 
LEU OXT HXT  sing N N 267 
LYS N   CA   sing N N 268 
LYS N   H    sing N N 269 
LYS N   H2   sing N N 270 
LYS CA  C    sing N N 271 
LYS CA  CB   sing N N 272 
LYS CA  HA   sing N N 273 
LYS C   O    doub N N 274 
LYS C   OXT  sing N N 275 
LYS CB  CG   sing N N 276 
LYS CB  HB2  sing N N 277 
LYS CB  HB3  sing N N 278 
LYS CG  CD   sing N N 279 
LYS CG  HG2  sing N N 280 
LYS CG  HG3  sing N N 281 
LYS CD  CE   sing N N 282 
LYS CD  HD2  sing N N 283 
LYS CD  HD3  sing N N 284 
LYS CE  NZ   sing N N 285 
LYS CE  HE2  sing N N 286 
LYS CE  HE3  sing N N 287 
LYS NZ  HZ1  sing N N 288 
LYS NZ  HZ2  sing N N 289 
LYS NZ  HZ3  sing N N 290 
LYS OXT HXT  sing N N 291 
MET N   CA   sing N N 292 
MET N   H    sing N N 293 
MET N   H2   sing N N 294 
MET CA  C    sing N N 295 
MET CA  CB   sing N N 296 
MET CA  HA   sing N N 297 
MET C   O    doub N N 298 
MET C   OXT  sing N N 299 
MET CB  CG   sing N N 300 
MET CB  HB2  sing N N 301 
MET CB  HB3  sing N N 302 
MET CG  SD   sing N N 303 
MET CG  HG2  sing N N 304 
MET CG  HG3  sing N N 305 
MET SD  CE   sing N N 306 
MET CE  HE1  sing N N 307 
MET CE  HE2  sing N N 308 
MET CE  HE3  sing N N 309 
MET OXT HXT  sing N N 310 
PHE N   CA   sing N N 311 
PHE N   H    sing N N 312 
PHE N   H2   sing N N 313 
PHE CA  C    sing N N 314 
PHE CA  CB   sing N N 315 
PHE CA  HA   sing N N 316 
PHE C   O    doub N N 317 
PHE C   OXT  sing N N 318 
PHE CB  CG   sing N N 319 
PHE CB  HB2  sing N N 320 
PHE CB  HB3  sing N N 321 
PHE CG  CD1  doub Y N 322 
PHE CG  CD2  sing Y N 323 
PHE CD1 CE1  sing Y N 324 
PHE CD1 HD1  sing N N 325 
PHE CD2 CE2  doub Y N 326 
PHE CD2 HD2  sing N N 327 
PHE CE1 CZ   doub Y N 328 
PHE CE1 HE1  sing N N 329 
PHE CE2 CZ   sing Y N 330 
PHE CE2 HE2  sing N N 331 
PHE CZ  HZ   sing N N 332 
PHE OXT HXT  sing N N 333 
PRO N   CA   sing N N 334 
PRO N   CD   sing N N 335 
PRO N   H    sing N N 336 
PRO CA  C    sing N N 337 
PRO CA  CB   sing N N 338 
PRO CA  HA   sing N N 339 
PRO C   O    doub N N 340 
PRO C   OXT  sing N N 341 
PRO CB  CG   sing N N 342 
PRO CB  HB2  sing N N 343 
PRO CB  HB3  sing N N 344 
PRO CG  CD   sing N N 345 
PRO CG  HG2  sing N N 346 
PRO CG  HG3  sing N N 347 
PRO CD  HD2  sing N N 348 
PRO CD  HD3  sing N N 349 
PRO OXT HXT  sing N N 350 
SER N   CA   sing N N 351 
SER N   H    sing N N 352 
SER N   H2   sing N N 353 
SER CA  C    sing N N 354 
SER CA  CB   sing N N 355 
SER CA  HA   sing N N 356 
SER C   O    doub N N 357 
SER C   OXT  sing N N 358 
SER CB  OG   sing N N 359 
SER CB  HB2  sing N N 360 
SER CB  HB3  sing N N 361 
SER OG  HG   sing N N 362 
SER OXT HXT  sing N N 363 
THR N   CA   sing N N 364 
THR N   H    sing N N 365 
THR N   H2   sing N N 366 
THR CA  C    sing N N 367 
THR CA  CB   sing N N 368 
THR CA  HA   sing N N 369 
THR C   O    doub N N 370 
THR C   OXT  sing N N 371 
THR CB  OG1  sing N N 372 
THR CB  CG2  sing N N 373 
THR CB  HB   sing N N 374 
THR OG1 HG1  sing N N 375 
THR CG2 HG21 sing N N 376 
THR CG2 HG22 sing N N 377 
THR CG2 HG23 sing N N 378 
THR OXT HXT  sing N N 379 
TRP N   CA   sing N N 380 
TRP N   H    sing N N 381 
TRP N   H2   sing N N 382 
TRP CA  C    sing N N 383 
TRP CA  CB   sing N N 384 
TRP CA  HA   sing N N 385 
TRP C   O    doub N N 386 
TRP C   OXT  sing N N 387 
TRP CB  CG   sing N N 388 
TRP CB  HB2  sing N N 389 
TRP CB  HB3  sing N N 390 
TRP CG  CD1  doub Y N 391 
TRP CG  CD2  sing Y N 392 
TRP CD1 NE1  sing Y N 393 
TRP CD1 HD1  sing N N 394 
TRP CD2 CE2  doub Y N 395 
TRP CD2 CE3  sing Y N 396 
TRP NE1 CE2  sing Y N 397 
TRP NE1 HE1  sing N N 398 
TRP CE2 CZ2  sing Y N 399 
TRP CE3 CZ3  doub Y N 400 
TRP CE3 HE3  sing N N 401 
TRP CZ2 CH2  doub Y N 402 
TRP CZ2 HZ2  sing N N 403 
TRP CZ3 CH2  sing Y N 404 
TRP CZ3 HZ3  sing N N 405 
TRP CH2 HH2  sing N N 406 
TRP OXT HXT  sing N N 407 
TYR N   CA   sing N N 408 
TYR N   H    sing N N 409 
TYR N   H2   sing N N 410 
TYR CA  C    sing N N 411 
TYR CA  CB   sing N N 412 
TYR CA  HA   sing N N 413 
TYR C   O    doub N N 414 
TYR C   OXT  sing N N 415 
TYR CB  CG   sing N N 416 
TYR CB  HB2  sing N N 417 
TYR CB  HB3  sing N N 418 
TYR CG  CD1  doub Y N 419 
TYR CG  CD2  sing Y N 420 
TYR CD1 CE1  sing Y N 421 
TYR CD1 HD1  sing N N 422 
TYR CD2 CE2  doub Y N 423 
TYR CD2 HD2  sing N N 424 
TYR CE1 CZ   doub Y N 425 
TYR CE1 HE1  sing N N 426 
TYR CE2 CZ   sing Y N 427 
TYR CE2 HE2  sing N N 428 
TYR CZ  OH   sing N N 429 
TYR OH  HH   sing N N 430 
TYR OXT HXT  sing N N 431 
VAL N   CA   sing N N 432 
VAL N   H    sing N N 433 
VAL N   H2   sing N N 434 
VAL CA  C    sing N N 435 
VAL CA  CB   sing N N 436 
VAL CA  HA   sing N N 437 
VAL C   O    doub N N 438 
VAL C   OXT  sing N N 439 
VAL CB  CG1  sing N N 440 
VAL CB  CG2  sing N N 441 
VAL CB  HB   sing N N 442 
VAL CG1 HG11 sing N N 443 
VAL CG1 HG12 sing N N 444 
VAL CG1 HG13 sing N N 445 
VAL CG2 HG21 sing N N 446 
VAL CG2 HG22 sing N N 447 
VAL CG2 HG23 sing N N 448 
VAL OXT HXT  sing N N 449 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-08-14 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9D61 
_em_admin.last_update        2025-05-21 
_em_admin.map_release_date   2025-01-15 
_em_admin.title              'Kappa opioid receptor:Galphai protein in complex with inverse agonist JDTic , no scFv16' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 20    mM HEPES 1 HEPES             
1 150   mM NaCl  2 'sodium chloride' 
1 0.001 %  LMNG  3 detergent         
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    YES 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                KILODALTONS/NANOMETER 
_em_entity_assembly_molwt.value                130 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          7108 
_em_entity_assembly_recombinant.organism             'Spodoptera frugiperda' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 BIOQUANTUM (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     ? 
# 
_em_imaging_optics.chr_aberration_corrector   ? 
_em_imaging_optics.energyfilter_lower         ? 
_em_imaging_optics.energyfilter_slit_width    20 
_em_imaging_optics.energyfilter_name          'GIF Bioquantum' 
_em_imaging_optics.energyfilter_upper         ? 
_em_imaging_optics.id                         1 
_em_imaging_optics.imaging_id                 1 
_em_imaging_optics.phase_plate                ? 
_em_imaging_optics.sph_aberration_corrector   ? 
_em_imaging_optics.details                    ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?         ?      
'IMAGE ACQUISITION'             ? 2  ? ? 1 EPU       2      
MASKING                         ? 3  ? ? ? ?         ?      
'CTF CORRECTION'                ? 4  1 ? ? cryoSPARC v4.3.1 
'LAYERLINE INDEXING'            ? 5  ? ? ? ?         ?      
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?         ?      
'MODEL FITTING'                 ? 7  ? ? ? ?         ?      
'MODEL REFINEMENT'              ? 8  ? ? ? PHENIX    ?      
OTHER                           ? 9  ? ? ? ?         ?      
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? cryoSPARC v4.3.1 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? cryoSPARC v4.3.1 
CLASSIFICATION                  ? 12 1 ? ? cryoSPARC v4.3.1 
RECONSTRUCTION                  ? 13 1 ? ? cryoSPARC v4.3.1 
'VOLUME SELECTION'              ? 14 1 1 1 ?         ?      
'SERIES ALIGNMENT'              ? 15 1 1 1 ?         ?      
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?         ?      
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?         ?      
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?         ?      
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?         ?      
# 
_em_specimen.concentration           18 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)'           'United States' GM144965 1 
'National Institutes of Health/National Center for Complementary and Integrative Health (NIH/NCCIH)' 'United States' AT012075 2 
# 
_atom_sites.entry_id                    9D61 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ALA A 1 57  ? 189.617 168.384 118.527 1.00 103.58 ? 57  ALA A N   1 
ATOM   2    C CA  . ALA A 1 57  ? 189.316 169.810 118.529 1.00 103.58 ? 57  ALA A CA  1 
ATOM   3    C C   . ALA A 1 57  ? 187.930 170.072 119.109 1.00 103.58 ? 57  ALA A C   1 
ATOM   4    O O   . ALA A 1 57  ? 187.800 170.681 120.171 1.00 103.58 ? 57  ALA A O   1 
ATOM   5    C CB  . ALA A 1 57  ? 189.419 170.377 117.121 1.00 103.58 ? 57  ALA A CB  1 
ATOM   6    N N   . ILE A 1 58  ? 186.901 169.617 118.388 1.00 103.12 ? 58  ILE A N   1 
ATOM   7    C CA  . ILE A 1 58  ? 185.523 169.779 118.864 1.00 103.12 ? 58  ILE A CA  1 
ATOM   8    C C   . ILE A 1 58  ? 185.254 169.036 120.175 1.00 103.12 ? 58  ILE A C   1 
ATOM   9    O O   . ILE A 1 58  ? 184.710 169.655 121.105 1.00 103.12 ? 58  ILE A O   1 
ATOM   10   C CB  . ILE A 1 58  ? 184.526 169.423 117.751 1.00 103.12 ? 58  ILE A CB  1 
ATOM   11   C CG1 . ILE A 1 58  ? 184.624 170.397 116.568 1.00 103.12 ? 58  ILE A CG1 1 
ATOM   12   C CG2 . ILE A 1 58  ? 183.098 169.403 118.282 1.00 103.12 ? 58  ILE A CG2 1 
ATOM   13   C CD1 . ILE A 1 58  ? 185.525 169.942 115.429 1.00 103.12 ? 58  ILE A CD1 1 
ATOM   14   N N   . PRO A 1 59  ? 185.607 167.746 120.338 1.00 101.11 ? 59  PRO A N   1 
ATOM   15   C CA  . PRO A 1 59  ? 185.314 167.098 121.629 1.00 101.11 ? 59  PRO A CA  1 
ATOM   16   C C   . PRO A 1 59  ? 186.239 167.511 122.764 1.00 101.11 ? 59  PRO A C   1 
ATOM   17   O O   . PRO A 1 59  ? 186.030 167.051 123.893 1.00 101.11 ? 59  PRO A O   1 
ATOM   18   C CB  . PRO A 1 59  ? 185.469 165.606 121.318 1.00 101.11 ? 59  PRO A CB  1 
ATOM   19   C CG  . PRO A 1 59  ? 186.477 165.574 120.266 1.00 101.11 ? 59  PRO A CG  1 
ATOM   20   C CD  . PRO A 1 59  ? 186.139 166.740 119.389 1.00 101.11 ? 59  PRO A CD  1 
ATOM   21   N N   . VAL A 1 60  ? 187.252 168.341 122.509 1.00 97.50  ? 60  VAL A N   1 
ATOM   22   C CA  . VAL A 1 60  ? 188.182 168.728 123.566 1.00 97.50  ? 60  VAL A CA  1 
ATOM   23   C C   . VAL A 1 60  ? 187.494 169.621 124.591 1.00 97.50  ? 60  VAL A C   1 
ATOM   24   O O   . VAL A 1 60  ? 187.597 169.397 125.803 1.00 97.50  ? 60  VAL A O   1 
ATOM   25   C CB  . VAL A 1 60  ? 189.420 169.416 122.962 1.00 97.50  ? 60  VAL A CB  1 
ATOM   26   C CG1 . VAL A 1 60  ? 190.406 169.790 124.055 1.00 97.50  ? 60  VAL A CG1 1 
ATOM   27   C CG2 . VAL A 1 60  ? 190.078 168.508 121.943 1.00 97.50  ? 60  VAL A CG2 1 
ATOM   28   N N   . ILE A 1 61  ? 186.771 170.637 124.121 1.00 98.72  ? 61  ILE A N   1 
ATOM   29   C CA  . ILE A 1 61  ? 186.213 171.638 125.026 1.00 98.72  ? 61  ILE A CA  1 
ATOM   30   C C   . ILE A 1 61  ? 185.014 171.073 125.782 1.00 98.72  ? 61  ILE A C   1 
ATOM   31   O O   . ILE A 1 61  ? 184.895 171.245 127.002 1.00 98.72  ? 61  ILE A O   1 
ATOM   32   C CB  . ILE A 1 61  ? 185.847 172.925 124.259 1.00 98.72  ? 61  ILE A CB  1 
ATOM   33   C CG1 . ILE A 1 61  ? 187.092 173.611 123.680 1.00 98.72  ? 61  ILE A CG1 1 
ATOM   34   C CG2 . ILE A 1 61  ? 185.097 173.901 125.155 1.00 98.72  ? 61  ILE A CG2 1 
ATOM   35   C CD1 . ILE A 1 61  ? 187.440 173.234 122.248 1.00 98.72  ? 61  ILE A CD1 1 
ATOM   36   N N   . ILE A 1 62  ? 184.118 170.380 125.072 1.00 96.56  ? 62  ILE A N   1 
ATOM   37   C CA  . ILE A 1 62  ? 182.857 169.946 125.670 1.00 96.56  ? 62  ILE A CA  1 
ATOM   38   C C   . ILE A 1 62  ? 183.096 168.881 126.736 1.00 96.56  ? 62  ILE A C   1 
ATOM   39   O O   . ILE A 1 62  ? 182.452 168.889 127.792 1.00 96.56  ? 62  ILE A O   1 
ATOM   40   C CB  . ILE A 1 62  ? 181.880 169.473 124.573 1.00 96.56  ? 62  ILE A CB  1 
ATOM   41   C CG1 . ILE A 1 62  ? 180.584 168.930 125.182 1.00 96.56  ? 62  ILE A CG1 1 
ATOM   42   C CG2 . ILE A 1 62  ? 182.527 168.456 123.641 1.00 96.56  ? 62  ILE A CG2 1 
ATOM   43   C CD1 . ILE A 1 62  ? 179.493 168.673 124.166 1.00 96.56  ? 62  ILE A CD1 1 
ATOM   44   N N   . THR A 1 63  ? 184.053 167.978 126.504 1.00 96.95  ? 63  THR A N   1 
ATOM   45   C CA  . THR A 1 63  ? 184.387 166.979 127.513 1.00 96.95  ? 63  THR A CA  1 
ATOM   46   C C   . THR A 1 63  ? 185.024 167.620 128.739 1.00 96.95  ? 63  THR A C   1 
ATOM   47   O O   . THR A 1 63  ? 184.771 167.191 129.870 1.00 96.95  ? 63  THR A O   1 
ATOM   48   C CB  . THR A 1 63  ? 185.313 165.919 126.920 1.00 96.95  ? 63  THR A CB  1 
ATOM   49   O OG1 . THR A 1 63  ? 186.368 166.560 126.191 1.00 96.95  ? 63  THR A OG1 1 
ATOM   50   C CG2 . THR A 1 63  ? 184.538 164.996 125.991 1.00 96.95  ? 63  THR A CG2 1 
ATOM   51   N N   . ALA A 1 64  ? 185.849 168.651 128.534 1.00 98.57  ? 64  ALA A N   1 
ATOM   52   C CA  . ALA A 1 64  ? 186.454 169.356 129.660 1.00 98.57  ? 64  ALA A CA  1 
ATOM   53   C C   . ALA A 1 64  ? 185.402 170.076 130.497 1.00 98.57  ? 64  ALA A C   1 
ATOM   54   O O   . ALA A 1 64  ? 185.445 170.026 131.732 1.00 98.57  ? 64  ALA A O   1 
ATOM   55   C CB  . ALA A 1 64  ? 187.507 170.342 129.158 1.00 98.57  ? 64  ALA A CB  1 
ATOM   56   N N   . VAL A 1 65  ? 184.444 170.739 129.842 1.00 97.60  ? 65  VAL A N   1 
ATOM   57   C CA  . VAL A 1 65  ? 183.375 171.422 130.569 1.00 97.60  ? 65  VAL A CA  1 
ATOM   58   C C   . VAL A 1 65  ? 182.481 170.409 131.277 1.00 97.60  ? 65  VAL A C   1 
ATOM   59   O O   . VAL A 1 65  ? 182.019 170.646 132.401 1.00 97.60  ? 65  VAL A O   1 
ATOM   60   C CB  . VAL A 1 65  ? 182.579 172.332 129.613 1.00 97.60  ? 65  VAL A CB  1 
ATOM   61   C CG1 . VAL A 1 65  ? 181.423 173.011 130.333 1.00 97.60  ? 65  VAL A CG1 1 
ATOM   62   C CG2 . VAL A 1 65  ? 183.493 173.385 129.011 1.00 97.60  ? 65  VAL A CG2 1 
ATOM   63   N N   . TYR A 1 66  ? 182.246 169.257 130.644 1.00 90.83  ? 66  TYR A N   1 
ATOM   64   C CA  . TYR A 1 66  ? 181.471 168.195 131.275 1.00 90.83  ? 66  TYR A CA  1 
ATOM   65   C C   . TYR A 1 66  ? 182.171 167.656 132.517 1.00 90.83  ? 66  TYR A C   1 
ATOM   66   O O   . TYR A 1 66  ? 181.530 167.426 133.548 1.00 90.83  ? 66  TYR A O   1 
ATOM   67   C CB  . TYR A 1 66  ? 181.230 167.071 130.273 1.00 90.83  ? 66  TYR A CB  1 
ATOM   68   C CG  . TYR A 1 66  ? 180.186 166.081 130.712 1.00 90.83  ? 66  TYR A CG  1 
ATOM   69   C CD1 . TYR A 1 66  ? 178.834 166.365 130.577 1.00 90.83  ? 66  TYR A CD1 1 
ATOM   70   C CD2 . TYR A 1 66  ? 180.551 164.866 131.272 1.00 90.83  ? 66  TYR A CD2 1 
ATOM   71   C CE1 . TYR A 1 66  ? 177.874 165.461 130.979 1.00 90.83  ? 66  TYR A CE1 1 
ATOM   72   C CE2 . TYR A 1 66  ? 179.601 163.958 131.678 1.00 90.83  ? 66  TYR A CE2 1 
ATOM   73   C CZ  . TYR A 1 66  ? 178.264 164.259 131.529 1.00 90.83  ? 66  TYR A CZ  1 
ATOM   74   O OH  . TYR A 1 66  ? 177.314 163.354 131.930 1.00 90.83  ? 66  TYR A OH  1 
ATOM   75   N N   . SER A 1 67  ? 183.488 167.460 132.440 1.00 94.68  ? 67  SER A N   1 
ATOM   76   C CA  . SER A 1 67  ? 184.243 167.002 133.602 1.00 94.68  ? 67  SER A CA  1 
ATOM   77   C C   . SER A 1 67  ? 184.249 168.051 134.708 1.00 94.68  ? 67  SER A C   1 
ATOM   78   O O   . SER A 1 67  ? 184.153 167.709 135.892 1.00 94.68  ? 67  SER A O   1 
ATOM   79   C CB  . SER A 1 67  ? 185.672 166.646 133.192 1.00 94.68  ? 67  SER A CB  1 
ATOM   80   O OG  . SER A 1 67  ? 186.466 166.340 134.325 1.00 94.68  ? 67  SER A OG  1 
ATOM   81   N N   . VAL A 1 68  ? 184.355 169.330 134.339 1.00 94.36  ? 68  VAL A N   1 
ATOM   82   C CA  . VAL A 1 68  ? 184.361 170.403 135.331 1.00 94.36  ? 68  VAL A CA  1 
ATOM   83   C C   . VAL A 1 68  ? 183.014 170.482 136.045 1.00 94.36  ? 68  VAL A C   1 
ATOM   84   O O   . VAL A 1 68  ? 182.954 170.593 137.277 1.00 94.36  ? 68  VAL A O   1 
ATOM   85   C CB  . VAL A 1 68  ? 184.740 171.740 134.664 1.00 94.36  ? 68  VAL A CB  1 
ATOM   86   C CG1 . VAL A 1 68  ? 184.281 172.929 135.501 1.00 94.36  ? 68  VAL A CG1 1 
ATOM   87   C CG2 . VAL A 1 68  ? 186.242 171.803 134.433 1.00 94.36  ? 68  VAL A CG2 1 
ATOM   88   N N   . VAL A 1 69  ? 181.915 170.405 135.288 1.00 93.53  ? 69  VAL A N   1 
ATOM   89   C CA  . VAL A 1 69  ? 180.600 170.480 135.918 1.00 93.53  ? 69  VAL A CA  1 
ATOM   90   C C   . VAL A 1 69  ? 180.315 169.210 136.718 1.00 93.53  ? 69  VAL A C   1 
ATOM   91   O O   . VAL A 1 69  ? 179.659 169.269 137.763 1.00 93.53  ? 69  VAL A O   1 
ATOM   92   C CB  . VAL A 1 69  ? 179.501 170.798 134.878 1.00 93.53  ? 69  VAL A CB  1 
ATOM   93   C CG1 . VAL A 1 69  ? 179.213 169.628 133.952 1.00 93.53  ? 69  VAL A CG1 1 
ATOM   94   C CG2 . VAL A 1 69  ? 178.229 171.265 135.572 1.00 93.53  ? 69  VAL A CG2 1 
ATOM   95   N N   . PHE A 1 70  ? 180.854 168.066 136.284 1.00 90.65  ? 70  PHE A N   1 
ATOM   96   C CA  . PHE A 1 70  ? 180.778 166.830 137.056 1.00 90.65  ? 70  PHE A CA  1 
ATOM   97   C C   . PHE A 1 70  ? 181.485 166.970 138.401 1.00 90.65  ? 70  PHE A C   1 
ATOM   98   O O   . PHE A 1 70  ? 180.939 166.598 139.449 1.00 90.65  ? 70  PHE A O   1 
ATOM   99   C CB  . PHE A 1 70  ? 181.385 165.705 136.212 1.00 90.65  ? 70  PHE A CB  1 
ATOM   100  C CG  . PHE A 1 70  ? 181.731 164.461 136.974 1.00 90.65  ? 70  PHE A CG  1 
ATOM   101  C CD1 . PHE A 1 70  ? 180.747 163.646 137.501 1.00 90.65  ? 70  PHE A CD1 1 
ATOM   102  C CD2 . PHE A 1 70  ? 183.057 164.084 137.120 1.00 90.65  ? 70  PHE A CD2 1 
ATOM   103  C CE1 . PHE A 1 70  ? 181.083 162.493 138.186 1.00 90.65  ? 70  PHE A CE1 1 
ATOM   104  C CE2 . PHE A 1 70  ? 183.397 162.933 137.800 1.00 90.65  ? 70  PHE A CE2 1 
ATOM   105  C CZ  . PHE A 1 70  ? 182.408 162.134 138.330 1.00 90.65  ? 70  PHE A CZ  1 
ATOM   106  N N   . VAL A 1 71  ? 182.689 167.548 138.388 1.00 93.16  ? 71  VAL A N   1 
ATOM   107  C CA  . VAL A 1 71  ? 183.470 167.713 139.611 1.00 93.16  ? 71  VAL A CA  1 
ATOM   108  C C   . VAL A 1 71  ? 182.786 168.692 140.560 1.00 93.16  ? 71  VAL A C   1 
ATOM   109  O O   . VAL A 1 71  ? 182.674 168.432 141.767 1.00 93.16  ? 71  VAL A O   1 
ATOM   110  C CB  . VAL A 1 71  ? 184.905 168.156 139.265 1.00 93.16  ? 71  VAL A CB  1 
ATOM   111  C CG1 . VAL A 1 71  ? 185.605 168.766 140.473 1.00 93.16  ? 71  VAL A CG1 1 
ATOM   112  C CG2 . VAL A 1 71  ? 185.705 166.977 138.730 1.00 93.16  ? 71  VAL A CG2 1 
ATOM   113  N N   . VAL A 1 72  ? 182.304 169.824 140.032 1.00 93.72  ? 72  VAL A N   1 
ATOM   114  C CA  . VAL A 1 72  ? 181.687 170.810 140.916 1.00 93.72  ? 72  VAL A CA  1 
ATOM   115  C C   . VAL A 1 72  ? 180.339 170.312 141.432 1.00 93.72  ? 72  VAL A C   1 
ATOM   116  O O   . VAL A 1 72  ? 179.974 170.596 142.579 1.00 93.72  ? 72  VAL A O   1 
ATOM   117  C CB  . VAL A 1 72  ? 181.582 172.201 140.251 1.00 93.72  ? 72  VAL A CB  1 
ATOM   118  C CG1 . VAL A 1 72  ? 182.956 172.687 139.806 1.00 93.72  ? 72  VAL A CG1 1 
ATOM   119  C CG2 . VAL A 1 72  ? 180.597 172.219 139.101 1.00 93.72  ? 72  VAL A CG2 1 
ATOM   120  N N   . GLY A 1 73  ? 179.606 169.524 140.637 1.00 91.63  ? 73  GLY A N   1 
ATOM   121  C CA  . GLY A 1 73  ? 178.378 168.929 141.132 1.00 91.63  ? 73  GLY A CA  1 
ATOM   122  C C   . GLY A 1 73  ? 178.629 167.918 142.232 1.00 91.63  ? 73  GLY A C   1 
ATOM   123  O O   . GLY A 1 73  ? 177.917 167.901 143.241 1.00 91.63  ? 73  GLY A O   1 
ATOM   124  N N   . LEU A 1 74  ? 179.664 167.085 142.069 1.00 90.42  ? 74  LEU A N   1 
ATOM   125  C CA  . LEU A 1 74  ? 180.019 166.133 143.117 1.00 90.42  ? 74  LEU A CA  1 
ATOM   126  C C   . LEU A 1 74  ? 180.448 166.836 144.399 1.00 90.42  ? 74  LEU A C   1 
ATOM   127  O O   . LEU A 1 74  ? 180.024 166.449 145.492 1.00 90.42  ? 74  LEU A O   1 
ATOM   128  C CB  . LEU A 1 74  ? 181.123 165.189 142.642 1.00 90.42  ? 74  LEU A CB  1 
ATOM   129  C CG  . LEU A 1 74  ? 180.699 163.910 141.927 1.00 90.42  ? 74  LEU A CG  1 
ATOM   130  C CD1 . LEU A 1 74  ? 181.917 163.034 141.720 1.00 90.42  ? 74  LEU A CD1 1 
ATOM   131  C CD2 . LEU A 1 74  ? 179.643 163.172 142.735 1.00 90.42  ? 74  LEU A CD2 1 
ATOM   132  N N   . VAL A 1 75  ? 181.286 167.872 144.292 1.00 91.55  ? 75  VAL A N   1 
ATOM   133  C CA  . VAL A 1 75  ? 181.782 168.507 145.513 1.00 91.55  ? 75  VAL A CA  1 
ATOM   134  C C   . VAL A 1 75  ? 180.675 169.316 146.190 1.00 91.55  ? 75  VAL A C   1 
ATOM   135  O O   . VAL A 1 75  ? 180.582 169.340 147.426 1.00 91.55  ? 75  VAL A O   1 
ATOM   136  C CB  . VAL A 1 75  ? 183.054 169.342 145.237 1.00 91.55  ? 75  VAL A CB  1 
ATOM   137  C CG1 . VAL A 1 75  ? 182.783 170.564 144.380 1.00 91.55  ? 75  VAL A CG1 1 
ATOM   138  C CG2 . VAL A 1 75  ? 183.727 169.744 146.547 1.00 91.55  ? 75  VAL A CG2 1 
ATOM   139  N N   . GLY A 1 76  ? 179.788 169.940 145.406 1.00 89.06  ? 76  GLY A N   1 
ATOM   140  C CA  . GLY A 1 76  ? 178.667 170.650 145.996 1.00 89.06  ? 76  GLY A CA  1 
ATOM   141  C C   . GLY A 1 76  ? 177.684 169.720 146.678 1.00 89.06  ? 76  GLY A C   1 
ATOM   142  O O   . GLY A 1 76  ? 177.216 170.001 147.785 1.00 89.06  ? 76  GLY A O   1 
ATOM   143  N N   . ASN A 1 77  ? 177.378 168.587 146.042 1.00 85.34  ? 77  ASN A N   1 
ATOM   144  C CA  . ASN A 1 77  ? 176.481 167.624 146.662 1.00 85.34  ? 77  ASN A CA  1 
ATOM   145  C C   . ASN A 1 77  ? 177.116 166.972 147.883 1.00 85.34  ? 77  ASN A C   1 
ATOM   146  O O   . ASN A 1 77  ? 176.420 166.694 148.866 1.00 85.34  ? 77  ASN A O   1 
ATOM   147  C CB  . ASN A 1 77  ? 176.066 166.576 145.636 1.00 85.34  ? 77  ASN A CB  1 
ATOM   148  C CG  . ASN A 1 77  ? 174.786 165.886 146.008 1.00 85.34  ? 77  ASN A CG  1 
ATOM   149  O OD1 . ASN A 1 77  ? 174.227 166.131 147.069 1.00 85.34  ? 77  ASN A OD1 1 
ATOM   150  N ND2 . ASN A 1 77  ? 174.301 165.033 145.129 1.00 85.34  ? 77  ASN A ND2 1 
ATOM   151  N N   . SER A 1 78  ? 178.434 166.750 147.852 1.00 90.24  ? 78  SER A N   1 
ATOM   152  C CA  . SER A 1 78  ? 179.127 166.196 149.009 1.00 90.24  ? 78  SER A CA  1 
ATOM   153  C C   . SER A 1 78  ? 179.095 167.158 150.189 1.00 90.24  ? 78  SER A C   1 
ATOM   154  O O   . SER A 1 78  ? 178.836 166.743 151.325 1.00 90.24  ? 78  SER A O   1 
ATOM   155  C CB  . SER A 1 78  ? 180.568 165.850 148.636 1.00 90.24  ? 78  SER A CB  1 
ATOM   156  O OG  . SER A 1 78  ? 180.607 164.873 147.611 1.00 90.24  ? 78  SER A OG  1 
ATOM   157  N N   . LEU A 1 79  ? 179.337 168.452 149.941 1.00 89.04  ? 79  LEU A N   1 
ATOM   158  C CA  . LEU A 1 79  ? 179.287 169.408 151.044 1.00 89.04  ? 79  LEU A CA  1 
ATOM   159  C C   . LEU A 1 79  ? 177.861 169.606 151.550 1.00 89.04  ? 79  LEU A C   1 
ATOM   160  O O   . LEU A 1 79  ? 177.662 169.786 152.757 1.00 89.04  ? 79  LEU A O   1 
ATOM   161  C CB  . LEU A 1 79  ? 179.925 170.743 150.639 1.00 89.04  ? 79  LEU A CB  1 
ATOM   162  C CG  . LEU A 1 79  ? 179.419 171.646 149.509 1.00 89.04  ? 79  LEU A CG  1 
ATOM   163  C CD1 . LEU A 1 79  ? 178.339 172.622 149.970 1.00 89.04  ? 79  LEU A CD1 1 
ATOM   164  C CD2 . LEU A 1 79  ? 180.582 172.400 148.880 1.00 89.04  ? 79  LEU A CD2 1 
ATOM   165  N N   . VAL A 1 80  ? 176.864 169.553 150.658 1.00 88.06  ? 80  VAL A N   1 
ATOM   166  C CA  . VAL A 1 80  ? 175.469 169.661 151.083 1.00 88.06  ? 80  VAL A CA  1 
ATOM   167  C C   . VAL A 1 80  ? 175.080 168.474 151.959 1.00 88.06  ? 80  VAL A C   1 
ATOM   168  O O   . VAL A 1 80  ? 174.451 168.641 153.013 1.00 88.06  ? 80  VAL A O   1 
ATOM   169  C CB  . VAL A 1 80  ? 174.549 169.798 149.853 1.00 88.06  ? 80  VAL A CB  1 
ATOM   170  C CG1 . VAL A 1 80  ? 173.116 169.391 150.180 1.00 88.06  ? 80  VAL A CG1 1 
ATOM   171  C CG2 . VAL A 1 80  ? 174.583 171.226 149.327 1.00 88.06  ? 80  VAL A CG2 1 
ATOM   172  N N   . MET A 1 81  ? 175.469 167.263 151.550 1.00 87.42  ? 81  MET A N   1 
ATOM   173  C CA  . MET A 1 81  ? 175.204 166.078 152.360 1.00 87.42  ? 81  MET A CA  1 
ATOM   174  C C   . MET A 1 81  ? 175.925 166.146 153.700 1.00 87.42  ? 81  MET A C   1 
ATOM   175  O O   . MET A 1 81  ? 175.356 165.781 154.737 1.00 87.42  ? 81  MET A O   1 
ATOM   176  C CB  . MET A 1 81  ? 175.613 164.823 151.592 1.00 87.42  ? 81  MET A CB  1 
ATOM   177  C CG  . MET A 1 81  ? 174.633 164.422 150.508 1.00 87.42  ? 81  MET A CG  1 
ATOM   178  S SD  . MET A 1 81  ? 173.182 163.606 151.192 1.00 87.42  ? 81  MET A SD  1 
ATOM   179  C CE  . MET A 1 81  ? 173.889 162.019 151.629 1.00 87.42  ? 81  MET A CE  1 
ATOM   180  N N   . PHE A 1 82  ? 177.170 166.632 153.702 1.00 90.32  ? 82  PHE A N   1 
ATOM   181  C CA  . PHE A 1 82  ? 177.929 166.734 154.945 1.00 90.32  ? 82  PHE A CA  1 
ATOM   182  C C   . PHE A 1 82  ? 177.297 167.728 155.913 1.00 90.32  ? 82  PHE A C   1 
ATOM   183  O O   . PHE A 1 82  ? 177.193 167.444 157.114 1.00 90.32  ? 82  PHE A O   1 
ATOM   184  C CB  . PHE A 1 82  ? 179.375 167.127 154.643 1.00 90.32  ? 82  PHE A CB  1 
ATOM   185  N N   . VAL A 1 83  ? 176.863 168.892 155.419 1.00 86.96  ? 83  VAL A N   1 
ATOM   186  C CA  . VAL A 1 83  ? 176.283 169.879 156.327 1.00 86.96  ? 83  VAL A CA  1 
ATOM   187  C C   . VAL A 1 83  ? 174.896 169.442 156.788 1.00 86.96  ? 83  VAL A C   1 
ATOM   188  O O   . VAL A 1 83  ? 174.523 169.667 157.944 1.00 86.96  ? 83  VAL A O   1 
ATOM   189  C CB  . VAL A 1 83  ? 176.278 171.292 155.703 1.00 86.96  ? 83  VAL A CB  1 
ATOM   190  C CG1 . VAL A 1 83  ? 177.701 171.738 155.393 1.00 86.96  ? 83  VAL A CG1 1 
ATOM   191  C CG2 . VAL A 1 83  ? 175.401 171.381 154.465 1.00 86.96  ? 83  VAL A CG2 1 
ATOM   192  N N   . ILE A 1 84  ? 174.131 168.761 155.929 1.00 84.39  ? 84  ILE A N   1 
ATOM   193  C CA  . ILE A 1 84  ? 172.824 168.281 156.365 1.00 84.39  ? 84  ILE A CA  1 
ATOM   194  C C   . ILE A 1 84  ? 172.943 167.052 157.258 1.00 84.39  ? 84  ILE A C   1 
ATOM   195  O O   . ILE A 1 84  ? 171.974 166.693 157.939 1.00 84.39  ? 84  ILE A O   1 
ATOM   196  C CB  . ILE A 1 84  ? 171.916 167.998 155.154 1.00 84.39  ? 84  ILE A CB  1 
ATOM   197  C CG1 . ILE A 1 84  ? 170.447 168.204 155.526 1.00 84.39  ? 84  ILE A CG1 1 
ATOM   198  C CG2 . ILE A 1 84  ? 172.140 166.595 154.606 1.00 84.39  ? 84  ILE A CG2 1 
ATOM   199  C CD1 . ILE A 1 84  ? 169.502 168.040 154.369 1.00 84.39  ? 84  ILE A CD1 1 
ATOM   200  N N   . ILE A 1 85  ? 174.106 166.404 157.292 1.00 87.43  ? 85  ILE A N   1 
ATOM   201  C CA  . ILE A 1 85  ? 174.298 165.255 158.167 1.00 87.43  ? 85  ILE A CA  1 
ATOM   202  C C   . ILE A 1 85  ? 174.823 165.698 159.527 1.00 87.43  ? 85  ILE A C   1 
ATOM   203  O O   . ILE A 1 85  ? 174.348 165.226 160.566 1.00 87.43  ? 85  ILE A O   1 
ATOM   204  C CB  . ILE A 1 85  ? 175.247 164.227 157.525 1.00 87.43  ? 85  ILE A CB  1 
ATOM   205  N N   . ARG A 1 86  ? 175.799 166.614 159.541 1.00 87.03  ? 86  ARG A N   1 
ATOM   206  C CA  . ARG A 1 86  ? 176.525 166.905 160.769 1.00 87.03  ? 86  ARG A CA  1 
ATOM   207  C C   . ARG A 1 86  ? 176.637 168.383 161.125 1.00 87.03  ? 86  ARG A C   1 
ATOM   208  O O   . ARG A 1 86  ? 177.373 168.713 162.062 1.00 87.03  ? 86  ARG A O   1 
ATOM   209  C CB  . ARG A 1 86  ? 177.940 166.308 160.699 1.00 87.03  ? 86  ARG A CB  1 
ATOM   210  N N   . TYR A 1 87  ? 175.949 169.280 160.420 1.00 82.53  ? 87  TYR A N   1 
ATOM   211  C CA  . TYR A 1 87  ? 175.983 170.698 160.751 1.00 82.53  ? 87  TYR A CA  1 
ATOM   212  C C   . TYR A 1 87  ? 174.614 171.353 160.813 1.00 82.53  ? 87  TYR A C   1 
ATOM   213  O O   . TYR A 1 87  ? 174.459 172.336 161.548 1.00 82.53  ? 87  TYR A O   1 
ATOM   214  C CB  . TYR A 1 87  ? 176.850 171.466 159.741 1.00 82.53  ? 87  TYR A CB  1 
ATOM   215  N N   . THR A 1 88  ? 173.624 170.854 160.078 1.00 81.02  ? 88  THR A N   1 
ATOM   216  C CA  . THR A 1 88  ? 172.261 171.366 160.119 1.00 81.02  ? 88  THR A CA  1 
ATOM   217  C C   . THR A 1 88  ? 171.338 170.237 160.548 1.00 81.02  ? 88  THR A C   1 
ATOM   218  O O   . THR A 1 88  ? 171.415 169.129 160.006 1.00 81.02  ? 88  THR A O   1 
ATOM   219  C CB  . THR A 1 88  ? 171.836 171.920 158.754 1.00 81.02  ? 88  THR A CB  1 
ATOM   220  O OG1 . THR A 1 88  ? 172.686 173.018 158.398 1.00 81.02  ? 88  THR A OG1 1 
ATOM   221  C CG2 . THR A 1 88  ? 170.394 172.401 158.789 1.00 81.02  ? 88  THR A CG2 1 
ATOM   222  N N   . LYS A 1 89  ? 170.483 170.514 161.530 1.00 73.52  ? 89  LYS A N   1 
ATOM   223  C CA  . LYS A 1 89  ? 169.570 169.503 162.041 1.00 73.52  ? 89  LYS A CA  1 
ATOM   224  C C   . LYS A 1 89  ? 168.544 169.112 160.982 1.00 73.52  ? 89  LYS A C   1 
ATOM   225  O O   . LYS A 1 89  ? 168.085 169.939 160.190 1.00 73.52  ? 89  LYS A O   1 
ATOM   226  C CB  . LYS A 1 89  ? 168.860 170.011 163.296 1.00 73.52  ? 89  LYS A CB  1 
ATOM   227  N N   . MET A 1 90  ? 168.192 167.829 160.974 1.00 67.59  ? 90  MET A N   1 
ATOM   228  C CA  . MET A 1 90  ? 167.229 167.270 160.028 1.00 67.59  ? 90  MET A CA  1 
ATOM   229  C C   . MET A 1 90  ? 165.962 166.937 160.807 1.00 67.59  ? 90  MET A C   1 
ATOM   230  O O   . MET A 1 90  ? 165.763 165.805 161.253 1.00 67.59  ? 90  MET A O   1 
ATOM   231  C CB  . MET A 1 90  ? 167.811 166.040 159.328 1.00 67.59  ? 90  MET A CB  1 
ATOM   232  C CG  . MET A 1 90  ? 166.944 165.481 158.214 1.00 67.59  ? 90  MET A CG  1 
ATOM   233  S SD  . MET A 1 90  ? 167.676 164.027 157.438 1.00 67.59  ? 90  MET A SD  1 
ATOM   234  C CE  . MET A 1 90  ? 169.021 164.770 156.519 1.00 67.59  ? 90  MET A CE  1 
ATOM   235  N N   . LYS A 1 91  ? 165.105 167.941 160.977 1.00 64.60  ? 91  LYS A N   1 
ATOM   236  C CA  . LYS A 1 91  ? 163.823 167.751 161.642 1.00 64.60  ? 91  LYS A CA  1 
ATOM   237  C C   . LYS A 1 91  ? 162.715 168.392 160.819 1.00 64.60  ? 91  LYS A C   1 
ATOM   238  O O   . LYS A 1 91  ? 161.556 167.968 160.880 1.00 64.60  ? 91  LYS A O   1 
ATOM   239  C CB  . LYS A 1 91  ? 163.855 168.338 163.054 1.00 64.60  ? 91  LYS A CB  1 
ATOM   240  N N   . THR A 1 92  ? 163.072 169.415 160.048 1.00 60.71  ? 92  THR A N   1 
ATOM   241  C CA  . THR A 1 92  ? 162.114 170.095 159.192 1.00 60.71  ? 92  THR A CA  1 
ATOM   242  C C   . THR A 1 92  ? 161.697 169.179 158.047 1.00 60.71  ? 92  THR A C   1 
ATOM   243  O O   . THR A 1 92  ? 162.489 168.374 157.550 1.00 60.71  ? 92  THR A O   1 
ATOM   244  C CB  . THR A 1 92  ? 162.721 171.388 158.644 1.00 60.71  ? 92  THR A CB  1 
ATOM   245  O OG1 . THR A 1 92  ? 163.452 172.046 159.684 1.00 60.71  ? 92  THR A OG1 1 
ATOM   246  C CG2 . THR A 1 92  ? 161.631 172.332 158.158 1.00 60.71  ? 92  THR A CG2 1 
ATOM   247  N N   . ALA A 1 93  ? 160.428 169.295 157.644 1.00 56.66  ? 93  ALA A N   1 
ATOM   248  C CA  . ALA A 1 93  ? 159.900 168.437 156.588 1.00 56.66  ? 93  ALA A CA  1 
ATOM   249  C C   . ALA A 1 93  ? 160.586 168.691 155.252 1.00 56.66  ? 93  ALA A C   1 
ATOM   250  O O   . ALA A 1 93  ? 160.691 167.775 154.430 1.00 56.66  ? 93  ALA A O   1 
ATOM   251  C CB  . ALA A 1 93  ? 158.391 168.635 156.457 1.00 56.66  ? 93  ALA A CB  1 
ATOM   252  N N   . THR A 1 94  ? 161.061 169.916 155.014 1.00 58.12  ? 94  THR A N   1 
ATOM   253  C CA  . THR A 1 94  ? 161.797 170.193 153.785 1.00 58.12  ? 94  THR A CA  1 
ATOM   254  C C   . THR A 1 94  ? 163.247 169.730 153.860 1.00 58.12  ? 94  THR A C   1 
ATOM   255  O O   . THR A 1 94  ? 163.891 169.583 152.812 1.00 58.12  ? 94  THR A O   1 
ATOM   256  C CB  . THR A 1 94  ? 161.744 171.687 153.452 1.00 58.12  ? 94  THR A CB  1 
ATOM   257  O OG1 . THR A 1 94  ? 162.388 171.919 152.193 1.00 58.12  ? 94  THR A OG1 1 
ATOM   258  C CG2 . THR A 1 94  ? 162.441 172.508 154.524 1.00 58.12  ? 94  THR A CG2 1 
ATOM   259  N N   . ASN A 1 95  ? 163.771 169.495 155.068 1.00 60.75  ? 95  ASN A N   1 
ATOM   260  C CA  . ASN A 1 95  ? 165.142 169.013 155.198 1.00 60.75  ? 95  ASN A CA  1 
ATOM   261  C C   . ASN A 1 95  ? 165.285 167.605 154.637 1.00 60.75  ? 95  ASN A C   1 
ATOM   262  O O   . ASN A 1 95  ? 166.262 167.303 153.942 1.00 60.75  ? 95  ASN A O   1 
ATOM   263  C CB  . ASN A 1 95  ? 165.586 169.058 156.659 1.00 60.75  ? 95  ASN A CB  1 
ATOM   264  C CG  . ASN A 1 95  ? 166.301 170.347 157.010 1.00 60.75  ? 95  ASN A CG  1 
ATOM   265  O OD1 . ASN A 1 95  ? 166.977 170.943 156.170 1.00 60.75  ? 95  ASN A OD1 1 
ATOM   266  N ND2 . ASN A 1 95  ? 166.165 170.779 158.258 1.00 60.75  ? 95  ASN A ND2 1 
ATOM   267  N N   . ILE A 1 96  ? 164.307 166.737 154.900 1.00 57.67  ? 96  ILE A N   1 
ATOM   268  C CA  . ILE A 1 96  ? 164.371 165.397 154.333 1.00 57.67  ? 96  ILE A CA  1 
ATOM   269  C C   . ILE A 1 96  ? 164.181 165.442 152.818 1.00 57.67  ? 96  ILE A C   1 
ATOM   270  O O   . ILE A 1 96  ? 164.761 164.626 152.094 1.00 57.67  ? 96  ILE A O   1 
ATOM   271  C CB  . ILE A 1 96  ? 163.365 164.460 155.035 1.00 57.67  ? 96  ILE A CB  1 
ATOM   272  C CG1 . ILE A 1 96  ? 161.924 164.731 154.604 1.00 57.67  ? 96  ILE A CG1 1 
ATOM   273  C CG2 . ILE A 1 96  ? 163.486 164.596 156.543 1.00 57.67  ? 96  ILE A CG2 1 
ATOM   274  C CD1 . ILE A 1 96  ? 160.967 163.624 154.966 1.00 57.67  ? 96  ILE A CD1 1 
ATOM   275  N N   . TYR A 1 97  ? 163.440 166.429 152.303 1.00 51.80  ? 97  TYR A N   1 
ATOM   276  C CA  . TYR A 1 97  ? 163.233 166.516 150.861 1.00 51.80  ? 97  TYR A CA  1 
ATOM   277  C C   . TYR A 1 97  ? 164.499 166.971 150.145 1.00 51.80  ? 97  TYR A C   1 
ATOM   278  O O   . TYR A 1 97  ? 164.870 166.406 149.107 1.00 51.80  ? 97  TYR A O   1 
ATOM   279  C CB  . TYR A 1 97  ? 162.074 167.461 150.553 1.00 51.80  ? 97  TYR A CB  1 
ATOM   280  C CG  . TYR A 1 97  ? 160.720 166.903 150.921 1.00 51.80  ? 97  TYR A CG  1 
ATOM   281  C CD1 . TYR A 1 97  ? 160.432 165.556 150.757 1.00 51.80  ? 97  TYR A CD1 1 
ATOM   282  C CD2 . TYR A 1 97  ? 159.726 167.727 151.425 1.00 51.80  ? 97  TYR A CD2 1 
ATOM   283  C CE1 . TYR A 1 97  ? 159.192 165.045 151.094 1.00 51.80  ? 97  TYR A CE1 1 
ATOM   284  C CE2 . TYR A 1 97  ? 158.486 167.226 151.765 1.00 51.80  ? 97  TYR A CE2 1 
ATOM   285  C CZ  . TYR A 1 97  ? 158.223 165.886 151.596 1.00 51.80  ? 97  TYR A CZ  1 
ATOM   286  O OH  . TYR A 1 97  ? 156.986 165.390 151.933 1.00 51.80  ? 97  TYR A OH  1 
ATOM   287  N N   . ILE A 1 98  ? 165.177 167.990 150.682 1.00 57.14  ? 98  ILE A N   1 
ATOM   288  C CA  . ILE A 1 98  ? 166.438 168.412 150.077 1.00 57.14  ? 98  ILE A CA  1 
ATOM   289  C C   . ILE A 1 98  ? 167.504 167.331 150.267 1.00 57.14  ? 98  ILE A C   1 
ATOM   290  O O   . ILE A 1 98  ? 168.394 167.172 149.421 1.00 57.14  ? 98  ILE A O   1 
ATOM   291  C CB  . ILE A 1 98  ? 166.864 169.794 150.622 1.00 57.14  ? 98  ILE A CB  1 
ATOM   292  C CG1 . ILE A 1 98  ? 168.091 170.334 149.885 1.00 57.14  ? 98  ILE A CG1 1 
ATOM   293  C CG2 . ILE A 1 98  ? 167.131 169.764 152.107 1.00 57.14  ? 98  ILE A CG2 1 
ATOM   294  C CD1 . ILE A 1 98  ? 168.494 171.721 150.334 1.00 57.14  ? 98  ILE A CD1 1 
ATOM   295  N N   . PHE A 1 99  ? 167.397 166.530 151.337 1.00 63.56  ? 99  PHE A N   1 
ATOM   296  C CA  . PHE A 1 99  ? 168.218 165.327 151.466 1.00 63.56  ? 99  PHE A CA  1 
ATOM   297  C C   . PHE A 1 99  ? 167.957 164.335 150.335 1.00 63.56  ? 99  PHE A C   1 
ATOM   298  O O   . PHE A 1 99  ? 168.897 163.733 149.800 1.00 63.56  ? 99  PHE A O   1 
ATOM   299  C CB  . PHE A 1 99  ? 167.953 164.674 152.823 1.00 63.56  ? 99  PHE A CB  1 
ATOM   300  C CG  . PHE A 1 99  ? 168.619 163.342 153.004 1.00 63.56  ? 99  PHE A CG  1 
ATOM   301  C CD1 . PHE A 1 99  ? 169.989 163.203 152.869 1.00 63.56  ? 99  PHE A CD1 1 
ATOM   302  C CD2 . PHE A 1 99  ? 167.862 162.222 153.310 1.00 63.56  ? 99  PHE A CD2 1 
ATOM   303  C CE1 . PHE A 1 99  ? 170.590 161.970 153.038 1.00 63.56  ? 99  PHE A CE1 1 
ATOM   304  C CE2 . PHE A 1 99  ? 168.456 160.989 153.480 1.00 63.56  ? 99  PHE A CE2 1 
ATOM   305  C CZ  . PHE A 1 99  ? 169.823 160.863 153.344 1.00 63.56  ? 99  PHE A CZ  1 
ATOM   306  N N   . ASN A 1 100 ? 166.685 164.136 149.974 1.00 60.37  ? 100 ASN A N   1 
ATOM   307  C CA  . ASN A 1 100 ? 166.359 163.221 148.881 1.00 60.37  ? 100 ASN A CA  1 
ATOM   308  C C   . ASN A 1 100 ? 166.901 163.731 147.552 1.00 60.37  ? 100 ASN A C   1 
ATOM   309  O O   . ASN A 1 100 ? 167.392 162.944 146.733 1.00 60.37  ? 100 ASN A O   1 
ATOM   310  C CB  . ASN A 1 100 ? 164.849 163.025 148.780 1.00 60.37  ? 100 ASN A CB  1 
ATOM   311  C CG  . ASN A 1 100 ? 164.257 162.445 150.034 1.00 60.37  ? 100 ASN A CG  1 
ATOM   312  O OD1 . ASN A 1 100 ? 163.222 162.906 150.504 1.00 60.37  ? 100 ASN A OD1 1 
ATOM   313  N ND2 . ASN A 1 100 ? 164.926 161.456 150.609 1.00 60.37  ? 100 ASN A ND2 1 
ATOM   314  N N   . LEU A 1 101 ? 166.798 165.044 147.316 1.00 58.33  ? 101 LEU A N   1 
ATOM   315  C CA  . LEU A 1 101 ? 167.401 165.639 146.122 1.00 58.33  ? 101 LEU A CA  1 
ATOM   316  C C   . LEU A 1 101 ? 168.908 165.430 146.095 1.00 58.33  ? 101 LEU A C   1 
ATOM   317  O O   . LEU A 1 101 ? 169.478 165.101 145.044 1.00 58.33  ? 101 LEU A O   1 
ATOM   318  C CB  . LEU A 1 101 ? 167.087 167.134 146.033 1.00 58.33  ? 101 LEU A CB  1 
ATOM   319  C CG  . LEU A 1 101 ? 165.819 167.643 145.341 1.00 58.33  ? 101 LEU A CG  1 
ATOM   320  C CD1 . LEU A 1 101 ? 165.871 167.263 143.872 1.00 58.33  ? 101 LEU A CD1 1 
ATOM   321  C CD2 . LEU A 1 101 ? 164.543 167.142 145.974 1.00 58.33  ? 101 LEU A CD2 1 
ATOM   322  N N   . ALA A 1 102 ? 169.566 165.619 147.242 1.00 65.78  ? 102 ALA A N   1 
ATOM   323  C CA  . ALA A 1 102 ? 171.006 165.405 147.331 1.00 65.78  ? 102 ALA A CA  1 
ATOM   324  C C   . ALA A 1 102 ? 171.377 163.963 147.008 1.00 65.78  ? 102 ALA A C   1 
ATOM   325  O O   . ALA A 1 102 ? 172.310 163.711 146.234 1.00 65.78  ? 102 ALA A O   1 
ATOM   326  C CB  . ALA A 1 102 ? 171.494 165.787 148.728 1.00 65.78  ? 102 ALA A CB  1 
ATOM   327  N N   . LEU A 1 103 ? 170.635 163.005 147.571 1.00 66.94  ? 103 LEU A N   1 
ATOM   328  C CA  . LEU A 1 103 ? 170.914 161.591 147.332 1.00 66.94  ? 103 LEU A CA  1 
ATOM   329  C C   . LEU A 1 103 ? 170.670 161.210 145.874 1.00 66.94  ? 103 LEU A C   1 
ATOM   330  O O   . LEU A 1 103 ? 171.450 160.449 145.290 1.00 66.94  ? 103 LEU A O   1 
ATOM   331  C CB  . LEU A 1 103 ? 170.071 160.732 148.281 1.00 66.94  ? 103 LEU A CB  1 
ATOM   332  C CG  . LEU A 1 103 ? 170.266 159.215 148.400 1.00 66.94  ? 103 LEU A CG  1 
ATOM   333  C CD1 . LEU A 1 103 ? 169.900 158.777 149.805 1.00 66.94  ? 103 LEU A CD1 1 
ATOM   334  C CD2 . LEU A 1 103 ? 169.412 158.439 147.405 1.00 66.94  ? 103 LEU A CD2 1 
ATOM   335  N N   . ALA A 1 104 ? 169.595 161.726 145.271 1.00 64.78  ? 104 ALA A N   1 
ATOM   336  C CA  . ALA A 1 104 ? 169.297 161.394 143.881 1.00 64.78  ? 104 ALA A CA  1 
ATOM   337  C C   . ALA A 1 104 ? 170.348 161.963 142.936 1.00 64.78  ? 104 ALA A C   1 
ATOM   338  O O   . ALA A 1 104 ? 170.788 161.282 141.997 1.00 64.78  ? 104 ALA A O   1 
ATOM   339  C CB  . ALA A 1 104 ? 167.905 161.904 143.512 1.00 64.78  ? 104 ALA A CB  1 
ATOM   340  N N   . ASP A 1 105 ? 170.779 163.205 143.178 1.00 68.34  ? 105 ASP A N   1 
ATOM   341  C CA  . ASP A 1 105 ? 171.841 163.782 142.362 1.00 68.34  ? 105 ASP A CA  1 
ATOM   342  C C   . ASP A 1 105 ? 173.157 163.038 142.561 1.00 68.34  ? 105 ASP A C   1 
ATOM   343  O O   . ASP A 1 105 ? 173.932 162.882 141.612 1.00 68.34  ? 105 ASP A O   1 
ATOM   344  C CB  . ASP A 1 105 ? 172.004 165.267 142.677 1.00 68.34  ? 105 ASP A CB  1 
ATOM   345  C CG  . ASP A 1 105 ? 170.810 166.084 142.240 1.00 68.34  ? 105 ASP A CG  1 
ATOM   346  O OD1 . ASP A 1 105 ? 170.122 165.665 141.287 1.00 68.34  ? 105 ASP A OD1 1 
ATOM   347  O OD2 . ASP A 1 105 ? 170.558 167.146 142.848 1.00 68.34  ? 105 ASP A OD2 1 
ATOM   348  N N   . ALA A 1 106 ? 173.418 162.558 143.780 1.00 69.75  ? 106 ALA A N   1 
ATOM   349  C CA  . ALA A 1 106 ? 174.635 161.790 144.025 1.00 69.75  ? 106 ALA A CA  1 
ATOM   350  C C   . ALA A 1 106 ? 174.595 160.448 143.307 1.00 69.75  ? 106 ALA A C   1 
ATOM   351  O O   . ALA A 1 106 ? 175.626 159.962 142.829 1.00 69.75  ? 106 ALA A O   1 
ATOM   352  C CB  . ALA A 1 106 ? 174.837 161.592 145.526 1.00 69.75  ? 106 ALA A CB  1 
ATOM   353  N N   . LEU A 1 107 ? 173.415 159.831 143.229 1.00 69.04  ? 107 LEU A N   1 
ATOM   354  C CA  . LEU A 1 107 ? 173.295 158.573 142.499 1.00 69.04  ? 107 LEU A CA  1 
ATOM   355  C C   . LEU A 1 107 ? 173.416 158.770 140.993 1.00 69.04  ? 107 LEU A C   1 
ATOM   356  O O   . LEU A 1 107 ? 173.937 157.889 140.300 1.00 69.04  ? 107 LEU A O   1 
ATOM   357  C CB  . LEU A 1 107 ? 171.973 157.883 142.837 1.00 69.04  ? 107 LEU A CB  1 
ATOM   358  C CG  . LEU A 1 107 ? 172.015 156.761 143.881 1.00 69.04  ? 107 LEU A CG  1 
ATOM   359  C CD1 . LEU A 1 107 ? 172.322 157.289 145.273 1.00 69.04  ? 107 LEU A CD1 1 
ATOM   360  C CD2 . LEU A 1 107 ? 170.711 155.982 143.876 1.00 69.04  ? 107 LEU A CD2 1 
ATOM   361  N N   . VAL A 1 108 ? 172.945 159.902 140.462 1.00 67.70  ? 108 VAL A N   1 
ATOM   362  C CA  . VAL A 1 108 ? 172.971 160.079 139.010 1.00 67.70  ? 108 VAL A CA  1 
ATOM   363  C C   . VAL A 1 108 ? 174.265 160.716 138.500 1.00 67.70  ? 108 VAL A C   1 
ATOM   364  O O   . VAL A 1 108 ? 174.614 160.531 137.324 1.00 67.70  ? 108 VAL A O   1 
ATOM   365  C CB  . VAL A 1 108 ? 171.754 160.900 138.544 1.00 67.70  ? 108 VAL A CB  1 
ATOM   366  C CG1 . VAL A 1 108 ? 171.898 162.373 138.919 1.00 67.70  ? 108 VAL A CG1 1 
ATOM   367  C CG2 . VAL A 1 108 ? 171.477 160.706 137.049 1.00 67.70  ? 108 VAL A CG2 1 
ATOM   368  N N   . THR A 1 109 ? 175.004 161.434 139.350 1.00 72.26  ? 109 THR A N   1 
ATOM   369  C CA  . THR A 1 109 ? 176.250 162.047 138.903 1.00 72.26  ? 109 THR A CA  1 
ATOM   370  C C   . THR A 1 109 ? 177.322 160.995 138.637 1.00 72.26  ? 109 THR A C   1 
ATOM   371  O O   . THR A 1 109 ? 178.245 161.234 137.852 1.00 72.26  ? 109 THR A O   1 
ATOM   372  C CB  . THR A 1 109 ? 176.723 163.062 139.946 1.00 72.26  ? 109 THR A CB  1 
ATOM   373  O OG1 . THR A 1 109 ? 175.598 163.810 140.420 1.00 72.26  ? 109 THR A OG1 1 
ATOM   374  C CG2 . THR A 1 109 ? 177.712 164.042 139.340 1.00 72.26  ? 109 THR A CG2 1 
ATOM   375  N N   . THR A 1 110 ? 177.200 159.821 139.263 1.00 74.29  ? 110 THR A N   1 
ATOM   376  C CA  . THR A 1 110 ? 178.133 158.724 139.034 1.00 74.29  ? 110 THR A CA  1 
ATOM   377  C C   . THR A 1 110 ? 178.097 158.231 137.588 1.00 74.29  ? 110 THR A C   1 
ATOM   378  O O   . THR A 1 110 ? 179.127 157.789 137.066 1.00 74.29  ? 110 THR A O   1 
ATOM   379  C CB  . THR A 1 110 ? 177.811 157.584 140.011 1.00 74.29  ? 110 THR A CB  1 
ATOM   380  O OG1 . THR A 1 110 ? 177.807 158.097 141.349 1.00 74.29  ? 110 THR A OG1 1 
ATOM   381  C CG2 . THR A 1 110 ? 178.846 156.466 139.935 1.00 74.29  ? 110 THR A CG2 1 
ATOM   382  N N   . THR A 1 111 ? 176.952 158.338 136.913 1.00 74.35  ? 111 THR A N   1 
ATOM   383  C CA  . THR A 1 111 ? 176.846 157.898 135.528 1.00 74.35  ? 111 THR A CA  1 
ATOM   384  C C   . THR A 1 111 ? 177.375 158.922 134.532 1.00 74.35  ? 111 THR A C   1 
ATOM   385  O O   . THR A 1 111 ? 177.357 158.649 133.327 1.00 74.35  ? 111 THR A O   1 
ATOM   386  C CB  . THR A 1 111 ? 175.392 157.566 135.181 1.00 74.35  ? 111 THR A CB  1 
ATOM   387  O OG1 . THR A 1 111 ? 174.593 158.752 135.272 1.00 74.35  ? 111 THR A OG1 1 
ATOM   388  C CG2 . THR A 1 111 ? 174.841 156.517 136.130 1.00 74.35  ? 111 THR A CG2 1 
ATOM   389  N N   . MET A 1 112 ? 177.814 160.091 134.996 1.00 79.75  ? 112 MET A N   1 
ATOM   390  C CA  . MET A 1 112 ? 178.388 161.076 134.082 1.00 79.75  ? 112 MET A CA  1 
ATOM   391  C C   . MET A 1 112 ? 179.681 160.613 133.404 1.00 79.75  ? 112 MET A C   1 
ATOM   392  O O   . MET A 1 112 ? 179.812 160.850 132.190 1.00 79.75  ? 112 MET A O   1 
ATOM   393  C CB  . MET A 1 112 ? 178.576 162.417 134.808 1.00 79.75  ? 112 MET A CB  1 
ATOM   394  N N   . PRO A 1 113 ? 180.664 159.991 134.084 1.00 82.18  ? 113 PRO A N   1 
ATOM   395  C CA  . PRO A 1 113 ? 181.772 159.387 133.321 1.00 82.18  ? 113 PRO A CA  1 
ATOM   396  C C   . PRO A 1 113 ? 181.333 158.292 132.366 1.00 82.18  ? 113 PRO A C   1 
ATOM   397  O O   . PRO A 1 113 ? 181.957 158.132 131.312 1.00 82.18  ? 113 PRO A O   1 
ATOM   398  C CB  . PRO A 1 113 ? 182.696 158.841 134.416 1.00 82.18  ? 113 PRO A CB  1 
ATOM   399  C CG  . PRO A 1 113 ? 182.449 159.715 135.564 1.00 82.18  ? 113 PRO A CG  1 
ATOM   400  C CD  . PRO A 1 113 ? 180.974 159.973 135.529 1.00 82.18  ? 113 PRO A CD  1 
ATOM   401  N N   . PHE A 1 114 ? 180.278 157.539 132.697 1.00 81.66  ? 114 PHE A N   1 
ATOM   402  C CA  . PHE A 1 114 ? 179.761 156.540 131.766 1.00 81.66  ? 114 PHE A CA  1 
ATOM   403  C C   . PHE A 1 114 ? 179.218 157.196 130.503 1.00 81.66  ? 114 PHE A C   1 
ATOM   404  O O   . PHE A 1 114 ? 179.483 156.729 129.389 1.00 81.66  ? 114 PHE A O   1 
ATOM   405  C CB  . PHE A 1 114 ? 178.672 155.697 132.432 1.00 81.66  ? 114 PHE A CB  1 
ATOM   406  C CG  . PHE A 1 114 ? 179.140 154.932 133.636 1.00 81.66  ? 114 PHE A CG  1 
ATOM   407  C CD1 . PHE A 1 114 ? 180.440 154.460 133.715 1.00 81.66  ? 114 PHE A CD1 1 
ATOM   408  C CD2 . PHE A 1 114 ? 178.272 154.672 134.683 1.00 81.66  ? 114 PHE A CD2 1 
ATOM   409  C CE1 . PHE A 1 114 ? 180.871 153.753 134.824 1.00 81.66  ? 114 PHE A CE1 1 
ATOM   410  C CE2 . PHE A 1 114 ? 178.695 153.965 135.795 1.00 81.66  ? 114 PHE A CE2 1 
ATOM   411  C CZ  . PHE A 1 114 ? 179.996 153.505 135.865 1.00 81.66  ? 114 PHE A CZ  1 
ATOM   412  N N   . GLN A 1 115 ? 178.469 158.290 130.661 1.00 78.44  ? 115 GLN A N   1 
ATOM   413  C CA  . GLN A 1 115 ? 177.955 159.017 129.504 1.00 78.44  ? 115 GLN A CA  1 
ATOM   414  C C   . GLN A 1 115 ? 179.088 159.632 128.691 1.00 78.44  ? 115 GLN A C   1 
ATOM   415  O O   . GLN A 1 115 ? 179.059 159.607 127.454 1.00 78.44  ? 115 GLN A O   1 
ATOM   416  C CB  . GLN A 1 115 ? 176.966 160.091 129.962 1.00 78.44  ? 115 GLN A CB  1 
ATOM   417  C CG  . GLN A 1 115 ? 176.472 161.011 128.857 1.00 78.44  ? 115 GLN A CG  1 
ATOM   418  C CD  . GLN A 1 115 ? 175.705 160.272 127.780 1.00 78.44  ? 115 GLN A CD  1 
ATOM   419  O OE1 . GLN A 1 115 ? 174.886 159.401 128.071 1.00 78.44  ? 115 GLN A OE1 1 
ATOM   420  N NE2 . GLN A 1 115 ? 175.968 160.617 126.526 1.00 78.44  ? 115 GLN A NE2 1 
ATOM   421  N N   . SER A 1 116 ? 180.108 160.164 129.371 1.00 82.31  ? 116 SER A N   1 
ATOM   422  C CA  . SER A 1 116 ? 181.247 160.748 128.668 1.00 82.31  ? 116 SER A CA  1 
ATOM   423  C C   . SER A 1 116 ? 182.015 159.698 127.874 1.00 82.31  ? 116 SER A C   1 
ATOM   424  O O   . SER A 1 116 ? 182.349 159.914 126.702 1.00 82.31  ? 116 SER A O   1 
ATOM   425  C CB  . SER A 1 116 ? 182.174 161.444 129.664 1.00 82.31  ? 116 SER A CB  1 
ATOM   426  O OG  . SER A 1 116 ? 182.956 160.499 130.373 1.00 82.31  ? 116 SER A OG  1 
ATOM   427  N N   . THR A 1 117 ? 182.277 158.539 128.480 1.00 85.39  ? 117 THR A N   1 
ATOM   428  C CA  . THR A 1 117 ? 183.041 157.520 127.776 1.00 85.39  ? 117 THR A CA  1 
ATOM   429  C C   . THR A 1 117 ? 182.210 156.821 126.704 1.00 85.39  ? 117 THR A C   1 
ATOM   430  O O   . THR A 1 117 ? 182.777 156.343 125.717 1.00 85.39  ? 117 THR A O   1 
ATOM   431  C CB  . THR A 1 117 ? 183.639 156.510 128.767 1.00 85.39  ? 117 THR A CB  1 
ATOM   432  O OG1 . THR A 1 117 ? 184.653 155.740 128.110 1.00 85.39  ? 117 THR A OG1 1 
ATOM   433  C CG2 . THR A 1 117 ? 182.584 155.565 129.332 1.00 85.39  ? 117 THR A CG2 1 
ATOM   434  N N   . VAL A 1 118 ? 180.879 156.790 126.833 1.00 81.95  ? 118 VAL A N   1 
ATOM   435  C CA  . VAL A 1 118 ? 180.097 156.207 125.750 1.00 81.95  ? 118 VAL A CA  1 
ATOM   436  C C   . VAL A 1 118 ? 179.943 157.210 124.610 1.00 81.95  ? 118 VAL A C   1 
ATOM   437  O O   . VAL A 1 118 ? 179.850 156.812 123.447 1.00 81.95  ? 118 VAL A O   1 
ATOM   438  C CB  . VAL A 1 118 ? 178.741 155.671 126.257 1.00 81.95  ? 118 VAL A CB  1 
ATOM   439  C CG1 . VAL A 1 118 ? 177.748 156.782 126.539 1.00 81.95  ? 118 VAL A CG1 1 
ATOM   440  C CG2 . VAL A 1 118 ? 178.156 154.678 125.265 1.00 81.95  ? 118 VAL A CG2 1 
ATOM   441  N N   . TYR A 1 119 ? 179.969 158.514 124.904 1.00 81.63  ? 119 TYR A N   1 
ATOM   442  C CA  . TYR A 1 119 ? 180.049 159.504 123.836 1.00 81.63  ? 119 TYR A CA  1 
ATOM   443  C C   . TYR A 1 119 ? 181.397 159.437 123.132 1.00 81.63  ? 119 TYR A C   1 
ATOM   444  O O   . TYR A 1 119 ? 181.484 159.648 121.916 1.00 81.63  ? 119 TYR A O   1 
ATOM   445  C CB  . TYR A 1 119 ? 179.799 160.901 124.402 1.00 81.63  ? 119 TYR A CB  1 
ATOM   446  C CG  . TYR A 1 119 ? 180.185 162.039 123.480 1.00 81.63  ? 119 TYR A CG  1 
ATOM   447  C CD1 . TYR A 1 119 ? 179.441 162.321 122.342 1.00 81.63  ? 119 TYR A CD1 1 
ATOM   448  C CD2 . TYR A 1 119 ? 181.281 162.846 123.762 1.00 81.63  ? 119 TYR A CD2 1 
ATOM   449  C CE1 . TYR A 1 119 ? 179.785 163.366 121.501 1.00 81.63  ? 119 TYR A CE1 1 
ATOM   450  C CE2 . TYR A 1 119 ? 181.633 163.893 122.928 1.00 81.63  ? 119 TYR A CE2 1 
ATOM   451  C CZ  . TYR A 1 119 ? 180.881 164.148 121.799 1.00 81.63  ? 119 TYR A CZ  1 
ATOM   452  O OH  . TYR A 1 119 ? 181.227 165.189 120.967 1.00 81.63  ? 119 TYR A OH  1 
ATOM   453  N N   . LEU A 1 120 ? 182.459 159.141 123.882 1.00 85.68  ? 120 LEU A N   1 
ATOM   454  C CA  . LEU A 1 120 ? 183.788 159.043 123.286 1.00 85.68  ? 120 LEU A CA  1 
ATOM   455  C C   . LEU A 1 120 ? 183.918 157.794 122.421 1.00 85.68  ? 120 LEU A C   1 
ATOM   456  O O   . LEU A 1 120 ? 184.154 157.881 121.210 1.00 85.68  ? 120 LEU A O   1 
ATOM   457  C CB  . LEU A 1 120 ? 184.852 159.048 124.386 1.00 85.68  ? 120 LEU A CB  1 
ATOM   458  C CG  . LEU A 1 120 ? 185.366 160.415 124.842 1.00 85.68  ? 120 LEU A CG  1 
ATOM   459  C CD1 . LEU A 1 120 ? 186.162 160.286 126.134 1.00 85.68  ? 120 LEU A CD1 1 
ATOM   460  C CD2 . LEU A 1 120 ? 186.204 161.068 123.754 1.00 85.68  ? 120 LEU A CD2 1 
ATOM   461  N N   . MET A 1 121 ? 183.759 156.617 123.027 1.00 87.47  ? 121 MET A N   1 
ATOM   462  C CA  . MET A 1 121 ? 183.995 155.351 122.349 1.00 87.47  ? 121 MET A CA  1 
ATOM   463  C C   . MET A 1 121 ? 182.820 154.916 121.481 1.00 87.47  ? 121 MET A C   1 
ATOM   464  O O   . MET A 1 121 ? 182.965 153.965 120.704 1.00 87.47  ? 121 MET A O   1 
ATOM   465  C CB  . MET A 1 121 ? 184.315 154.275 123.397 1.00 87.47  ? 121 MET A CB  1 
ATOM   466  C CG  . MET A 1 121 ? 185.065 153.052 122.879 1.00 87.47  ? 121 MET A CG  1 
ATOM   467  S SD  . MET A 1 121 ? 186.726 153.460 122.311 1.00 87.47  ? 121 MET A SD  1 
ATOM   468  C CE  . MET A 1 121 ? 187.022 152.135 121.144 1.00 87.47  ? 121 MET A CE  1 
ATOM   469  N N   . ASN A 1 122 ? 181.672 155.595 121.593 1.00 87.18  ? 122 ASN A N   1 
ATOM   470  C CA  . ASN A 1 122 ? 180.418 155.276 120.906 1.00 87.18  ? 122 ASN A CA  1 
ATOM   471  C C   . ASN A 1 122 ? 179.891 153.883 121.254 1.00 87.18  ? 122 ASN A C   1 
ATOM   472  O O   . ASN A 1 122 ? 179.056 153.337 120.527 1.00 87.18  ? 122 ASN A O   1 
ATOM   473  C CB  . ASN A 1 122 ? 180.554 155.439 119.386 1.00 87.18  ? 122 ASN A CB  1 
ATOM   474  C CG  . ASN A 1 122 ? 181.245 156.731 119.003 1.00 87.18  ? 122 ASN A CG  1 
ATOM   475  O OD1 . ASN A 1 122 ? 181.128 157.740 119.698 1.00 87.18  ? 122 ASN A OD1 1 
ATOM   476  N ND2 . ASN A 1 122 ? 181.978 156.706 117.897 1.00 87.18  ? 122 ASN A ND2 1 
ATOM   477  N N   . SER A 1 123 ? 180.338 153.321 122.373 1.00 87.51  ? 123 SER A N   1 
ATOM   478  C CA  . SER A 1 123 ? 179.939 152.003 122.870 1.00 87.51  ? 123 SER A CA  1 
ATOM   479  C C   . SER A 1 123 ? 180.434 151.898 124.310 1.00 87.51  ? 123 SER A C   1 
ATOM   480  O O   . SER A 1 123 ? 180.920 152.880 124.884 1.00 87.51  ? 123 SER A O   1 
ATOM   481  C CB  . SER A 1 123 ? 180.493 150.878 121.993 1.00 87.51  ? 123 SER A CB  1 
ATOM   482  O OG  . SER A 1 123 ? 181.851 151.110 121.666 1.00 87.51  ? 123 SER A OG  1 
ATOM   483  N N   . TRP A 1 124 ? 180.323 150.704 124.899 1.00 82.20  ? 124 TRP A N   1 
ATOM   484  C CA  . TRP A 1 124 ? 180.834 150.509 126.248 1.00 82.20  ? 124 TRP A CA  1 
ATOM   485  C C   . TRP A 1 124 ? 181.345 149.091 126.435 1.00 82.20  ? 124 TRP A C   1 
ATOM   486  O O   . TRP A 1 124 ? 180.743 148.148 125.903 1.00 82.20  ? 124 TRP A O   1 
ATOM   487  C CB  . TRP A 1 124 ? 179.772 150.804 127.311 1.00 82.20  ? 124 TRP A CB  1 
ATOM   488  C CG  . TRP A 1 124 ? 178.376 150.490 126.894 1.00 82.20  ? 124 TRP A CG  1 
ATOM   489  C CD1 . TRP A 1 124 ? 177.479 151.347 126.337 1.00 82.20  ? 124 TRP A CD1 1 
ATOM   490  C CD2 . TRP A 1 124 ? 177.709 149.230 127.006 1.00 82.20  ? 124 TRP A CD2 1 
ATOM   491  N NE1 . TRP A 1 124 ? 176.296 150.701 126.092 1.00 82.20  ? 124 TRP A NE1 1 
ATOM   492  C CE2 . TRP A 1 124 ? 176.412 149.398 126.494 1.00 82.20  ? 124 TRP A CE2 1 
ATOM   493  C CE3 . TRP A 1 124 ? 178.081 147.976 127.491 1.00 82.20  ? 124 TRP A CE3 1 
ATOM   494  C CZ2 . TRP A 1 124 ? 175.489 148.360 126.450 1.00 82.20  ? 124 TRP A CZ2 1 
ATOM   495  C CZ3 . TRP A 1 124 ? 177.161 146.949 127.448 1.00 82.20  ? 124 TRP A CZ3 1 
ATOM   496  C CH2 . TRP A 1 124 ? 175.886 147.144 126.925 1.00 82.20  ? 124 TRP A CH2 1 
ATOM   497  N N   . PRO A 1 125 ? 182.464 148.911 127.145 1.00 83.14  ? 125 PRO A N   1 
ATOM   498  C CA  . PRO A 1 125 ? 182.878 147.583 127.612 1.00 83.14  ? 125 PRO A CA  1 
ATOM   499  C C   . PRO A 1 125 ? 182.329 147.255 129.000 1.00 83.14  ? 125 PRO A C   1 
ATOM   500  O O   . PRO A 1 125 ? 183.075 146.911 129.924 1.00 83.14  ? 125 PRO A O   1 
ATOM   501  C CB  . PRO A 1 125 ? 184.409 147.688 127.623 1.00 83.14  ? 125 PRO A CB  1 
ATOM   502  C CG  . PRO A 1 125 ? 184.742 149.032 126.984 1.00 83.14  ? 125 PRO A CG  1 
ATOM   503  C CD  . PRO A 1 125 ? 183.557 149.882 127.268 1.00 83.14  ? 125 PRO A CD  1 
ATOM   504  N N   . PHE A 1 126 ? 181.010 147.362 129.160 1.00 81.59  ? 126 PHE A N   1 
ATOM   505  C CA  . PHE A 1 126 ? 180.381 147.221 130.468 1.00 81.59  ? 126 PHE A CA  1 
ATOM   506  C C   . PHE A 1 126 ? 179.557 145.956 130.632 1.00 81.59  ? 126 PHE A C   1 
ATOM   507  O O   . PHE A 1 126 ? 179.451 145.450 131.750 1.00 81.59  ? 126 PHE A O   1 
ATOM   508  C CB  . PHE A 1 126 ? 179.483 148.428 130.761 1.00 81.59  ? 126 PHE A CB  1 
ATOM   509  C CG  . PHE A 1 126 ? 180.238 149.698 131.005 1.00 81.59  ? 126 PHE A CG  1 
ATOM   510  C CD1 . PHE A 1 126 ? 181.552 149.664 131.438 1.00 81.59  ? 126 PHE A CD1 1 
ATOM   511  C CD2 . PHE A 1 126 ? 179.627 150.927 130.828 1.00 81.59  ? 126 PHE A CD2 1 
ATOM   512  C CE1 . PHE A 1 126 ? 182.249 150.832 131.669 1.00 81.59  ? 126 PHE A CE1 1 
ATOM   513  C CE2 . PHE A 1 126 ? 180.318 152.098 131.056 1.00 81.59  ? 126 PHE A CE2 1 
ATOM   514  C CZ  . PHE A 1 126 ? 181.631 152.050 131.478 1.00 81.59  ? 126 PHE A CZ  1 
ATOM   515  N N   . GLY A 1 127 ? 178.973 145.438 129.557 1.00 78.72  ? 127 GLY A N   1 
ATOM   516  C CA  . GLY A 1 127 ? 178.140 144.257 129.644 1.00 78.72  ? 127 GLY A CA  1 
ATOM   517  C C   . GLY A 1 127 ? 176.835 144.519 130.382 1.00 78.72  ? 127 GLY A C   1 
ATOM   518  O O   . GLY A 1 127 ? 176.394 145.656 130.563 1.00 78.72  ? 127 GLY A O   1 
ATOM   519  N N   . ASP A 1 128 ? 176.220 143.424 130.823 1.00 79.55  ? 128 ASP A N   1 
ATOM   520  C CA  . ASP A 1 128 ? 175.000 143.471 131.616 1.00 79.55  ? 128 ASP A CA  1 
ATOM   521  C C   . ASP A 1 128 ? 175.279 143.623 133.104 1.00 79.55  ? 128 ASP A C   1 
ATOM   522  O O   . ASP A 1 128 ? 174.334 143.625 133.900 1.00 79.55  ? 128 ASP A O   1 
ATOM   523  C CB  . ASP A 1 128 ? 174.165 142.211 131.380 1.00 79.55  ? 128 ASP A CB  1 
ATOM   524  C CG  . ASP A 1 128 ? 173.539 142.175 130.003 1.00 79.55  ? 128 ASP A CG  1 
ATOM   525  O OD1 . ASP A 1 128 ? 173.840 143.072 129.190 1.00 79.55  ? 128 ASP A OD1 1 
ATOM   526  O OD2 . ASP A 1 128 ? 172.748 141.248 129.734 1.00 79.55  ? 128 ASP A OD2 1 
ATOM   527  N N   . VAL A 1 129 ? 176.552 143.737 133.492 1.00 76.65  ? 129 VAL A N   1 
ATOM   528  C CA  . VAL A 1 129 ? 176.909 143.796 134.905 1.00 76.65  ? 129 VAL A CA  1 
ATOM   529  C C   . VAL A 1 129 ? 176.432 145.098 135.534 1.00 76.65  ? 129 VAL A C   1 
ATOM   530  O O   . VAL A 1 129 ? 175.843 145.097 136.621 1.00 76.65  ? 129 VAL A O   1 
ATOM   531  C CB  . VAL A 1 129 ? 178.428 143.612 135.077 1.00 76.65  ? 129 VAL A CB  1 
ATOM   532  C CG1 . VAL A 1 129 ? 178.780 143.454 136.548 1.00 76.65  ? 129 VAL A CG1 1 
ATOM   533  C CG2 . VAL A 1 129 ? 178.910 142.416 134.273 1.00 76.65  ? 129 VAL A CG2 1 
ATOM   534  N N   . LEU A 1 130 ? 176.665 146.228 134.864 1.00 73.33  ? 130 LEU A N   1 
ATOM   535  C CA  . LEU A 1 130 ? 176.298 147.510 135.452 1.00 73.33  ? 130 LEU A CA  1 
ATOM   536  C C   . LEU A 1 130 ? 175.488 148.431 134.551 1.00 73.33  ? 130 LEU A C   1 
ATOM   537  O O   . LEU A 1 130 ? 175.018 149.459 135.048 1.00 73.33  ? 130 LEU A O   1 
ATOM   538  C CB  . LEU A 1 130 ? 177.542 148.271 135.943 1.00 73.33  ? 130 LEU A CB  1 
ATOM   539  C CG  . LEU A 1 130 ? 178.537 148.921 134.983 1.00 73.33  ? 130 LEU A CG  1 
ATOM   540  C CD1 . LEU A 1 130 ? 179.383 149.910 135.754 1.00 73.33  ? 130 LEU A CD1 1 
ATOM   541  C CD2 . LEU A 1 130 ? 179.441 147.884 134.355 1.00 73.33  ? 130 LEU A CD2 1 
ATOM   542  N N   . CYS A 1 131 ? 175.282 148.114 133.269 1.00 76.82  ? 131 CYS A N   1 
ATOM   543  C CA  . CYS A 1 131 ? 174.357 148.926 132.484 1.00 76.82  ? 131 CYS A CA  1 
ATOM   544  C C   . CYS A 1 131 ? 172.938 148.775 133.010 1.00 76.82  ? 131 CYS A C   1 
ATOM   545  O O   . CYS A 1 131 ? 172.151 149.728 132.969 1.00 76.82  ? 131 CYS A O   1 
ATOM   546  C CB  . CYS A 1 131 ? 174.394 148.548 131.006 1.00 76.82  ? 131 CYS A CB  1 
ATOM   547  S SG  . CYS A 1 131 ? 173.448 147.074 130.603 1.00 76.82  ? 131 CYS A SG  1 
ATOM   548  N N   . LYS A 1 132 ? 172.612 147.590 133.532 1.00 73.34  ? 132 LYS A N   1 
ATOM   549  C CA  . LYS A 1 132 ? 171.304 147.353 134.131 1.00 73.34  ? 132 LYS A CA  1 
ATOM   550  C C   . LYS A 1 132 ? 171.082 148.247 135.348 1.00 73.34  ? 132 LYS A C   1 
ATOM   551  O O   . LYS A 1 132 ? 170.020 148.865 135.493 1.00 73.34  ? 132 LYS A O   1 
ATOM   552  C CB  . LYS A 1 132 ? 171.185 145.876 134.504 1.00 73.34  ? 132 LYS A CB  1 
ATOM   553  C CG  . LYS A 1 132 ? 169.782 145.407 134.813 1.00 73.34  ? 132 LYS A CG  1 
ATOM   554  C CD  . LYS A 1 132 ? 169.778 143.937 135.209 1.00 73.34  ? 132 LYS A CD  1 
ATOM   555  C CE  . LYS A 1 132 ? 170.023 143.029 134.017 1.00 73.34  ? 132 LYS A CE  1 
ATOM   556  N NZ  . LYS A 1 132 ? 168.871 143.032 133.073 1.00 73.34  ? 132 LYS A NZ  1 
ATOM   557  N N   . ILE A 1 133 ? 172.089 148.361 136.219 1.00 72.13  ? 133 ILE A N   1 
ATOM   558  C CA  . ILE A 1 133 ? 171.897 149.192 137.403 1.00 72.13  ? 133 ILE A CA  1 
ATOM   559  C C   . ILE A 1 133 ? 171.950 150.676 137.047 1.00 72.13  ? 133 ILE A C   1 
ATOM   560  O O   . ILE A 1 133 ? 171.216 151.478 137.637 1.00 72.13  ? 133 ILE A O   1 
ATOM   561  C CB  . ILE A 1 133 ? 172.890 148.826 138.528 1.00 72.13  ? 133 ILE A CB  1 
ATOM   562  C CG1 . ILE A 1 133 ? 174.341 149.113 138.143 1.00 72.13  ? 133 ILE A CG1 1 
ATOM   563  C CG2 . ILE A 1 133 ? 172.731 147.364 138.922 1.00 72.13  ? 133 ILE A CG2 1 
ATOM   564  C CD1 . ILE A 1 133 ? 175.313 149.022 139.298 1.00 72.13  ? 133 ILE A CD1 1 
ATOM   565  N N   . VAL A 1 134 ? 172.775 151.077 136.070 1.00 72.17  ? 134 VAL A N   1 
ATOM   566  C CA  . VAL A 1 134 ? 172.795 152.495 135.708 1.00 72.17  ? 134 VAL A CA  1 
ATOM   567  C C   . VAL A 1 134 ? 171.629 152.896 134.820 1.00 72.17  ? 134 VAL A C   1 
ATOM   568  O O   . VAL A 1 134 ? 171.436 154.095 134.582 1.00 72.17  ? 134 VAL A O   1 
ATOM   569  C CB  . VAL A 1 134 ? 174.096 152.942 135.014 1.00 72.17  ? 134 VAL A CB  1 
ATOM   570  C CG1 . VAL A 1 134 ? 175.310 152.569 135.850 1.00 72.17  ? 134 VAL A CG1 1 
ATOM   571  C CG2 . VAL A 1 134 ? 174.186 152.384 133.612 1.00 72.17  ? 134 VAL A CG2 1 
ATOM   572  N N   . ILE A 1 135 ? 170.848 151.941 134.315 1.00 69.78  ? 135 ILE A N   1 
ATOM   573  C CA  . ILE A 1 135 ? 169.582 152.282 133.679 1.00 69.78  ? 135 ILE A CA  1 
ATOM   574  C C   . ILE A 1 135 ? 168.411 152.176 134.655 1.00 69.78  ? 135 ILE A C   1 
ATOM   575  O O   . ILE A 1 135 ? 167.374 152.817 134.427 1.00 69.78  ? 135 ILE A O   1 
ATOM   576  C CB  . ILE A 1 135 ? 169.329 151.426 132.416 1.00 69.78  ? 135 ILE A CB  1 
ATOM   577  C CG1 . ILE A 1 135 ? 168.422 152.169 131.432 1.00 69.78  ? 135 ILE A CG1 1 
ATOM   578  C CG2 . ILE A 1 135 ? 168.703 150.082 132.753 1.00 69.78  ? 135 ILE A CG2 1 
ATOM   579  C CD1 . ILE A 1 135 ? 169.046 153.416 130.844 1.00 69.78  ? 135 ILE A CD1 1 
ATOM   580  N N   . SER A 1 136 ? 168.546 151.404 135.738 1.00 67.36  ? 136 SER A N   1 
ATOM   581  C CA  . SER A 1 136 ? 167.516 151.432 136.770 1.00 67.36  ? 136 SER A CA  1 
ATOM   582  C C   . SER A 1 136 ? 167.603 152.697 137.617 1.00 67.36  ? 136 SER A C   1 
ATOM   583  O O   . SER A 1 136 ? 166.573 153.313 137.926 1.00 67.36  ? 136 SER A O   1 
ATOM   584  C CB  . SER A 1 136 ? 167.616 150.192 137.656 1.00 67.36  ? 136 SER A CB  1 
ATOM   585  O OG  . SER A 1 136 ? 166.770 150.312 138.785 1.00 67.36  ? 136 SER A OG  1 
ATOM   586  N N   . ILE A 1 137 ? 168.818 153.111 137.994 1.00 65.13  ? 137 ILE A N   1 
ATOM   587  C CA  . ILE A 1 137 ? 168.959 154.317 138.802 1.00 65.13  ? 137 ILE A CA  1 
ATOM   588  C C   . ILE A 1 137 ? 168.638 155.583 138.027 1.00 65.13  ? 137 ILE A C   1 
ATOM   589  O O   . ILE A 1 137 ? 168.351 156.608 138.646 1.00 65.13  ? 137 ILE A O   1 
ATOM   590  C CB  . ILE A 1 137 ? 170.362 154.461 139.426 1.00 65.13  ? 137 ILE A CB  1 
ATOM   591  C CG1 . ILE A 1 137 ? 171.425 154.671 138.349 1.00 65.13  ? 137 ILE A CG1 1 
ATOM   592  C CG2 . ILE A 1 137 ? 170.678 153.268 140.318 1.00 65.13  ? 137 ILE A CG2 1 
ATOM   593  C CD1 . ILE A 1 137 ? 172.790 155.008 138.904 1.00 65.13  ? 137 ILE A CD1 1 
ATOM   594  N N   . ASP A 1 138 ? 168.646 155.534 136.694 1.00 63.86  ? 138 ASP A N   1 
ATOM   595  C CA  . ASP A 1 138 ? 168.166 156.656 135.892 1.00 63.86  ? 138 ASP A CA  1 
ATOM   596  C C   . ASP A 1 138 ? 166.687 156.937 136.137 1.00 63.86  ? 138 ASP A C   1 
ATOM   597  O O   . ASP A 1 138 ? 166.300 158.068 136.456 1.00 63.86  ? 138 ASP A O   1 
ATOM   598  C CB  . ASP A 1 138 ? 168.405 156.375 134.411 1.00 63.86  ? 138 ASP A CB  1 
ATOM   599  C CG  . ASP A 1 138 ? 167.734 157.387 133.525 1.00 63.86  ? 138 ASP A CG  1 
ATOM   600  O OD1 . ASP A 1 138 ? 168.182 158.548 133.503 1.00 63.86  ? 138 ASP A OD1 1 
ATOM   601  O OD2 . ASP A 1 138 ? 166.743 157.023 132.860 1.00 63.86  ? 138 ASP A OD2 1 
ATOM   602  N N   . TYR A 1 139 ? 165.848 155.908 136.005 1.00 59.37  ? 139 TYR A N   1 
ATOM   603  C CA  . TYR A 1 139 ? 164.426 156.078 136.267 1.00 59.37  ? 139 TYR A CA  1 
ATOM   604  C C   . TYR A 1 139 ? 164.170 156.322 137.744 1.00 59.37  ? 139 TYR A C   1 
ATOM   605  O O   . TYR A 1 139 ? 163.219 157.029 138.105 1.00 59.37  ? 139 TYR A O   1 
ATOM   606  C CB  . TYR A 1 139 ? 163.661 154.851 135.782 1.00 59.37  ? 139 TYR A CB  1 
ATOM   607  C CG  . TYR A 1 139 ? 163.719 154.692 134.286 1.00 59.37  ? 139 TYR A CG  1 
ATOM   608  C CD1 . TYR A 1 139 ? 163.371 155.737 133.447 1.00 59.37  ? 139 TYR A CD1 1 
ATOM   609  C CD2 . TYR A 1 139 ? 164.149 153.505 133.712 1.00 59.37  ? 139 TYR A CD2 1 
ATOM   610  C CE1 . TYR A 1 139 ? 163.433 155.600 132.076 1.00 59.37  ? 139 TYR A CE1 1 
ATOM   611  C CE2 . TYR A 1 139 ? 164.215 153.357 132.342 1.00 59.37  ? 139 TYR A CE2 1 
ATOM   612  C CZ  . TYR A 1 139 ? 163.857 154.408 131.528 1.00 59.37  ? 139 TYR A CZ  1 
ATOM   613  O OH  . TYR A 1 139 ? 163.921 154.266 130.160 1.00 59.37  ? 139 TYR A OH  1 
ATOM   614  N N   . TYR A 1 140 ? 165.019 155.756 138.605 1.00 59.05  ? 140 TYR A N   1 
ATOM   615  C CA  . TYR A 1 140 ? 164.925 156.010 140.038 1.00 59.05  ? 140 TYR A CA  1 
ATOM   616  C C   . TYR A 1 140 ? 165.147 157.490 140.342 1.00 59.05  ? 140 TYR A C   1 
ATOM   617  O O   . TYR A 1 140 ? 164.364 158.107 141.074 1.00 59.05  ? 140 TYR A O   1 
ATOM   618  C CB  . TYR A 1 140 ? 165.947 155.130 140.754 1.00 59.05  ? 140 TYR A CB  1 
ATOM   619  C CG  . TYR A 1 140 ? 165.794 154.991 142.243 1.00 59.05  ? 140 TYR A CG  1 
ATOM   620  C CD1 . TYR A 1 140 ? 164.801 154.180 142.778 1.00 59.05  ? 140 TYR A CD1 1 
ATOM   621  C CD2 . TYR A 1 140 ? 166.673 155.615 143.114 1.00 59.05  ? 140 TYR A CD2 1 
ATOM   622  C CE1 . TYR A 1 140 ? 164.667 154.021 144.139 1.00 59.05  ? 140 TYR A CE1 1 
ATOM   623  C CE2 . TYR A 1 140 ? 166.551 155.458 144.478 1.00 59.05  ? 140 TYR A CE2 1 
ATOM   624  C CZ  . TYR A 1 140 ? 165.543 154.663 144.986 1.00 59.05  ? 140 TYR A CZ  1 
ATOM   625  O OH  . TYR A 1 140 ? 165.409 154.498 146.344 1.00 59.05  ? 140 TYR A OH  1 
ATOM   626  N N   . ASN A 1 141 ? 166.184 158.087 139.735 1.00 55.69  ? 141 ASN A N   1 
ATOM   627  C CA  . ASN A 1 141 ? 166.421 159.525 139.845 1.00 55.69  ? 141 ASN A CA  1 
ATOM   628  C C   . ASN A 1 141 ? 165.264 160.333 139.286 1.00 55.69  ? 141 ASN A C   1 
ATOM   629  O O   . ASN A 1 141 ? 164.865 161.340 139.879 1.00 55.69  ? 141 ASN A O   1 
ATOM   630  C CB  . ASN A 1 141 ? 167.680 159.933 139.086 1.00 55.69  ? 141 ASN A CB  1 
ATOM   631  C CG  . ASN A 1 141 ? 168.022 161.400 139.288 1.00 55.69  ? 141 ASN A CG  1 
ATOM   632  O OD1 . ASN A 1 141 ? 167.595 162.022 140.257 1.00 55.69  ? 141 ASN A OD1 1 
ATOM   633  N ND2 . ASN A 1 141 ? 168.666 161.990 138.298 1.00 55.69  ? 141 ASN A ND2 1 
ATOM   634  N N   . MET A 1 142 ? 164.756 159.940 138.115 1.00 53.39  ? 142 MET A N   1 
ATOM   635  C CA  . MET A 1 142 ? 163.702 160.710 137.461 1.00 53.39  ? 142 MET A CA  1 
ATOM   636  C C   . MET A 1 142 ? 162.455 160.779 138.328 1.00 53.39  ? 142 MET A C   1 
ATOM   637  O O   . MET A 1 142 ? 161.948 161.870 138.628 1.00 53.39  ? 142 MET A O   1 
ATOM   638  C CB  . MET A 1 142 ? 163.367 160.081 136.115 1.00 53.39  ? 142 MET A CB  1 
ATOM   639  C CG  . MET A 1 142 ? 162.393 160.872 135.280 1.00 53.39  ? 142 MET A CG  1 
ATOM   640  S SD  . MET A 1 142 ? 161.824 159.850 133.919 1.00 53.39  ? 142 MET A SD  1 
ATOM   641  C CE  . MET A 1 142 ? 163.399 159.392 133.218 1.00 53.39  ? 142 MET A CE  1 
ATOM   642  N N   . PHE A 1 143 ? 161.974 159.617 138.773 1.00 51.94  ? 143 PHE A N   1 
ATOM   643  C CA  . PHE A 1 143 ? 160.783 159.580 139.608 1.00 51.94  ? 143 PHE A CA  1 
ATOM   644  C C   . PHE A 1 143 ? 161.032 160.230 140.963 1.00 51.94  ? 143 PHE A C   1 
ATOM   645  O O   . PHE A 1 143 ? 160.154 160.929 141.482 1.00 51.94  ? 143 PHE A O   1 
ATOM   646  C CB  . PHE A 1 143 ? 160.307 158.139 139.761 1.00 51.94  ? 143 PHE A CB  1 
ATOM   647  C CG  . PHE A 1 143 ? 159.352 157.709 138.688 1.00 51.94  ? 143 PHE A CG  1 
ATOM   648  C CD1 . PHE A 1 143 ? 159.805 157.440 137.409 1.00 51.94  ? 143 PHE A CD1 1 
ATOM   649  C CD2 . PHE A 1 143 ? 158.002 157.564 138.961 1.00 51.94  ? 143 PHE A CD2 1 
ATOM   650  C CE1 . PHE A 1 143 ? 158.929 157.043 136.418 1.00 51.94  ? 143 PHE A CE1 1 
ATOM   651  C CE2 . PHE A 1 143 ? 157.120 157.165 137.978 1.00 51.94  ? 143 PHE A CE2 1 
ATOM   652  C CZ  . PHE A 1 143 ? 157.584 156.904 136.704 1.00 51.94  ? 143 PHE A CZ  1 
ATOM   653  N N   . THR A 1 144 ? 162.234 160.052 141.529 1.00 49.17  ? 144 THR A N   1 
ATOM   654  C CA  . THR A 1 144 ? 162.553 160.672 142.810 1.00 49.17  ? 144 THR A CA  1 
ATOM   655  C C   . THR A 1 144 ? 162.532 162.190 142.723 1.00 49.17  ? 144 THR A C   1 
ATOM   656  O O   . THR A 1 144 ? 161.884 162.851 143.541 1.00 49.17  ? 144 THR A O   1 
ATOM   657  C CB  . THR A 1 144 ? 163.922 160.200 143.293 1.00 49.17  ? 144 THR A CB  1 
ATOM   658  O OG1 . THR A 1 144 ? 163.937 158.769 143.381 1.00 49.17  ? 144 THR A OG1 1 
ATOM   659  C CG2 . THR A 1 144 ? 164.242 160.801 144.646 1.00 49.17  ? 144 THR A CG2 1 
ATOM   660  N N   . SER A 1 145 ? 163.222 162.758 141.732 1.00 43.58  ? 145 SER A N   1 
ATOM   661  C CA  . SER A 1 145 ? 163.289 164.208 141.594 1.00 43.58  ? 145 SER A CA  1 
ATOM   662  C C   . SER A 1 145 ? 161.919 164.797 141.288 1.00 43.58  ? 145 SER A C   1 
ATOM   663  O O   . SER A 1 145 ? 161.516 165.798 141.896 1.00 43.58  ? 145 SER A O   1 
ATOM   664  C CB  . SER A 1 145 ? 164.297 164.582 140.506 1.00 43.58  ? 145 SER A CB  1 
ATOM   665  O OG  . SER A 1 145 ? 164.378 165.986 140.342 1.00 43.58  ? 145 SER A OG  1 
ATOM   666  N N   . ILE A 1 146 ? 161.169 164.163 140.379 1.00 42.98  ? 146 ILE A N   1 
ATOM   667  C CA  . ILE A 1 146 ? 159.857 164.686 140.014 1.00 42.98  ? 146 ILE A CA  1 
ATOM   668  C C   . ILE A 1 146 ? 158.897 164.631 141.197 1.00 42.98  ? 146 ILE A C   1 
ATOM   669  O O   . ILE A 1 146 ? 158.226 165.622 141.511 1.00 42.98  ? 146 ILE A O   1 
ATOM   670  C CB  . ILE A 1 146 ? 159.310 163.930 138.791 1.00 42.98  ? 146 ILE A CB  1 
ATOM   671  C CG1 . ILE A 1 146 ? 160.082 164.331 137.534 1.00 42.98  ? 146 ILE A CG1 1 
ATOM   672  C CG2 . ILE A 1 146 ? 157.837 164.195 138.607 1.00 42.98  ? 146 ILE A CG2 1 
ATOM   673  C CD1 . ILE A 1 146 ? 159.750 163.493 136.324 1.00 42.98  ? 146 ILE A CD1 1 
ATOM   674  N N   . PHE A 1 147 ? 158.847 163.502 141.908 1.00 42.52  ? 147 PHE A N   1 
ATOM   675  C CA  . PHE A 1 147 ? 157.890 163.394 142.998 1.00 42.52  ? 147 PHE A CA  1 
ATOM   676  C C   . PHE A 1 147 ? 158.318 164.169 144.239 1.00 42.52  ? 147 PHE A C   1 
ATOM   677  O O   . PHE A 1 147 ? 157.448 164.629 144.984 1.00 42.52  ? 147 PHE A O   1 
ATOM   678  C CB  . PHE A 1 147 ? 157.638 161.925 143.320 1.00 42.52  ? 147 PHE A CB  1 
ATOM   679  C CG  . PHE A 1 147 ? 156.610 161.293 142.427 1.00 42.52  ? 147 PHE A CG  1 
ATOM   680  C CD1 . PHE A 1 147 ? 155.259 161.455 142.685 1.00 42.52  ? 147 PHE A CD1 1 
ATOM   681  C CD2 . PHE A 1 147 ? 156.991 160.570 141.308 1.00 42.52  ? 147 PHE A CD2 1 
ATOM   682  C CE1 . PHE A 1 147 ? 154.307 160.885 141.860 1.00 42.52  ? 147 PHE A CE1 1 
ATOM   683  C CE2 . PHE A 1 147 ? 156.046 160.000 140.478 1.00 42.52  ? 147 PHE A CE2 1 
ATOM   684  C CZ  . PHE A 1 147 ? 154.702 160.158 140.754 1.00 42.52  ? 147 PHE A CZ  1 
ATOM   685  N N   . THR A 1 148 ? 159.620 164.374 144.461 1.00 40.23  ? 148 THR A N   1 
ATOM   686  C CA  . THR A 1 148 ? 160.029 165.246 145.557 1.00 40.23  ? 148 THR A CA  1 
ATOM   687  C C   . THR A 1 148 ? 159.731 166.707 145.245 1.00 40.23  ? 148 THR A C   1 
ATOM   688  O O   . THR A 1 148 ? 159.306 167.451 146.134 1.00 40.23  ? 148 THR A O   1 
ATOM   689  C CB  . THR A 1 148 ? 161.510 165.065 145.879 1.00 40.23  ? 148 THR A CB  1 
ATOM   690  O OG1 . THR A 1 148 ? 162.270 165.029 144.666 1.00 40.23  ? 148 THR A OG1 1 
ATOM   691  C CG2 . THR A 1 148 ? 161.738 163.794 146.678 1.00 40.23  ? 148 THR A CG2 1 
ATOM   692  N N   . LEU A 1 149 ? 159.934 167.144 143.995 1.00 34.44  ? 149 LEU A N   1 
ATOM   693  C CA  . LEU A 1 149 ? 159.556 168.512 143.648 1.00 34.44  ? 149 LEU A CA  1 
ATOM   694  C C   . LEU A 1 149 ? 158.046 168.703 143.648 1.00 34.44  ? 149 LEU A C   1 
ATOM   695  O O   . LEU A 1 149 ? 157.565 169.821 143.863 1.00 34.44  ? 149 LEU A O   1 
ATOM   696  C CB  . LEU A 1 149 ? 160.141 168.914 142.294 1.00 34.44  ? 149 LEU A CB  1 
ATOM   697  C CG  . LEU A 1 149 ? 161.518 169.584 142.262 1.00 34.44  ? 149 LEU A CG  1 
ATOM   698  C CD1 . LEU A 1 149 ? 161.446 170.923 142.973 1.00 34.44  ? 149 LEU A CD1 1 
ATOM   699  C CD2 . LEU A 1 149 ? 162.616 168.731 142.864 1.00 34.44  ? 149 LEU A CD2 1 
ATOM   700  N N   . THR A 1 150 ? 157.283 167.641 143.403 1.00 31.64  ? 150 THR A N   1 
ATOM   701  C CA  . THR A 1 150 ? 155.835 167.741 143.542 1.00 31.64  ? 150 THR A CA  1 
ATOM   702  C C   . THR A 1 150 ? 155.423 167.836 145.006 1.00 31.64  ? 150 THR A C   1 
ATOM   703  O O   . THR A 1 150 ? 154.631 168.709 145.381 1.00 31.64  ? 150 THR A O   1 
ATOM   704  C CB  . THR A 1 150 ? 155.164 166.542 142.879 1.00 31.64  ? 150 THR A CB  1 
ATOM   705  O OG1 . THR A 1 150 ? 155.467 166.547 141.482 1.00 31.64  ? 150 THR A OG1 1 
ATOM   706  C CG2 . THR A 1 150 ? 153.658 166.598 143.064 1.00 31.64  ? 150 THR A CG2 1 
ATOM   707  N N   . MET A 1 151 ? 155.970 166.957 145.851 1.00 33.35  ? 151 MET A N   1 
ATOM   708  C CA  . MET A 1 151 ? 155.547 166.912 147.245 1.00 33.35  ? 151 MET A CA  1 
ATOM   709  C C   . MET A 1 151 ? 156.060 168.104 148.036 1.00 33.35  ? 151 MET A C   1 
ATOM   710  O O   . MET A 1 151 ? 155.409 168.525 148.995 1.00 33.35  ? 151 MET A O   1 
ATOM   711  C CB  . MET A 1 151 ? 155.999 165.608 147.892 1.00 33.35  ? 151 MET A CB  1 
ATOM   712  C CG  . MET A 1 151 ? 154.993 164.481 147.748 1.00 33.35  ? 151 MET A CG  1 
ATOM   713  S SD  . MET A 1 151 ? 153.318 164.972 148.208 1.00 33.35  ? 151 MET A SD  1 
ATOM   714  C CE  . MET A 1 151 ? 152.481 164.910 146.625 1.00 33.35  ? 151 MET A CE  1 
ATOM   715  N N   . MET A 1 152 ? 157.202 168.673 147.649 1.00 29.75  ? 152 MET A N   1 
ATOM   716  C CA  . MET A 1 152 ? 157.668 169.893 148.295 1.00 29.75  ? 152 MET A CA  1 
ATOM   717  C C   . MET A 1 152 ? 156.728 171.058 148.008 1.00 29.75  ? 152 MET A C   1 
ATOM   718  O O   . MET A 1 152 ? 156.389 171.828 148.914 1.00 29.75  ? 152 MET A O   1 
ATOM   719  C CB  . MET A 1 152 ? 159.089 170.208 147.835 1.00 29.75  ? 152 MET A CB  1 
ATOM   720  C CG  . MET A 1 152 ? 159.747 171.354 148.573 1.00 29.75  ? 152 MET A CG  1 
ATOM   721  S SD  . MET A 1 152 ? 161.468 171.576 148.085 1.00 29.75  ? 152 MET A SD  1 
ATOM   722  C CE  . MET A 1 152 ? 161.268 172.266 146.448 1.00 29.75  ? 152 MET A CE  1 
ATOM   723  N N   . SER A 1 153 ? 156.271 171.181 146.758 1.00 25.63  ? 153 SER A N   1 
ATOM   724  C CA  . SER A 1 153 ? 155.324 172.236 146.410 1.00 25.63  ? 153 SER A CA  1 
ATOM   725  C C   . SER A 1 153 ? 153.973 172.013 147.079 1.00 25.63  ? 153 SER A C   1 
ATOM   726  O O   . SER A 1 153 ? 153.316 172.973 147.500 1.00 25.63  ? 153 SER A O   1 
ATOM   727  C CB  . SER A 1 153 ? 155.166 172.317 144.894 1.00 25.63  ? 153 SER A CB  1 
ATOM   728  O OG  . SER A 1 153 ? 154.058 173.126 144.547 1.00 25.63  ? 153 SER A OG  1 
ATOM   729  N N   . VAL A 1 154 ? 153.542 170.753 147.186 1.00 24.73  ? 154 VAL A N   1 
ATOM   730  C CA  . VAL A 1 154 ? 152.301 170.444 147.895 1.00 24.73  ? 154 VAL A CA  1 
ATOM   731  C C   . VAL A 1 154 ? 152.428 170.788 149.376 1.00 24.73  ? 154 VAL A C   1 
ATOM   732  O O   . VAL A 1 154 ? 151.491 171.319 149.986 1.00 24.73  ? 154 VAL A O   1 
ATOM   733  C CB  . VAL A 1 154 ? 151.921 168.967 147.680 1.00 24.73  ? 154 VAL A CB  1 
ATOM   734  C CG1 . VAL A 1 154 ? 150.814 168.536 148.629 1.00 24.73  ? 154 VAL A CG1 1 
ATOM   735  C CG2 . VAL A 1 154 ? 151.477 168.747 146.254 1.00 24.73  ? 154 VAL A CG2 1 
ATOM   736  N N   . ASP A 1 155 ? 153.590 170.511 149.969 1.00 27.55  ? 155 ASP A N   1 
ATOM   737  C CA  . ASP A 1 155 ? 153.828 170.853 151.368 1.00 27.55  ? 155 ASP A CA  1 
ATOM   738  C C   . ASP A 1 155 ? 153.809 172.363 151.581 1.00 27.55  ? 155 ASP A C   1 
ATOM   739  O O   . ASP A 1 155 ? 153.245 172.852 152.564 1.00 27.55  ? 155 ASP A O   1 
ATOM   740  C CB  . ASP A 1 155 ? 155.159 170.257 151.823 1.00 27.55  ? 155 ASP A CB  1 
ATOM   741  C CG  . ASP A 1 155 ? 155.665 170.873 153.105 1.00 27.55  ? 155 ASP A CG  1 
ATOM   742  O OD1 . ASP A 1 155 ? 155.142 170.523 154.182 1.00 27.55  ? 155 ASP A OD1 1 
ATOM   743  O OD2 . ASP A 1 155 ? 156.589 171.708 153.035 1.00 27.55  ? 155 ASP A OD2 1 
ATOM   744  N N   . ARG A 1 156 ? 154.407 173.120 150.657 1.00 23.55  ? 156 ARG A N   1 
ATOM   745  C CA  . ARG A 1 156 ? 154.373 174.579 150.760 1.00 23.55  ? 156 ARG A CA  1 
ATOM   746  C C   . ARG A 1 156 ? 152.955 175.123 150.600 1.00 23.55  ? 156 ARG A C   1 
ATOM   747  O O   . ARG A 1 156 ? 152.551 176.047 151.323 1.00 23.55  ? 156 ARG A O   1 
ATOM   748  C CB  . ARG A 1 156 ? 155.305 175.194 149.723 1.00 23.55  ? 156 ARG A CB  1 
ATOM   749  C CG  . ARG A 1 156 ? 156.760 174.838 149.937 1.00 23.55  ? 156 ARG A CG  1 
ATOM   750  C CD  . ARG A 1 156 ? 157.669 175.677 149.070 1.00 23.55  ? 156 ARG A CD  1 
ATOM   751  N NE  . ARG A 1 156 ? 159.064 175.553 149.468 1.00 23.55  ? 156 ARG A NE  1 
ATOM   752  C CZ  . ARG A 1 156 ? 160.074 175.450 148.615 1.00 23.55  ? 156 ARG A CZ  1 
ATOM   753  N NH1 . ARG A 1 156 ? 159.876 175.448 147.307 1.00 23.55  ? 156 ARG A NH1 1 
ATOM   754  N NH2 . ARG A 1 156 ? 161.313 175.347 149.086 1.00 23.55  ? 156 ARG A NH2 1 
ATOM   755  N N   . TYR A 1 157 ? 152.184 174.565 149.662 1.00 20.59  ? 157 TYR A N   1 
ATOM   756  C CA  . TYR A 1 157 ? 150.805 175.002 149.472 1.00 20.59  ? 157 TYR A CA  1 
ATOM   757  C C   . TYR A 1 157 ? 149.947 174.687 150.688 1.00 20.59  ? 157 TYR A C   1 
ATOM   758  O O   . TYR A 1 157 ? 149.102 175.499 151.081 1.00 20.59  ? 157 TYR A O   1 
ATOM   759  C CB  . TYR A 1 157 ? 150.206 174.351 148.229 1.00 20.59  ? 157 TYR A CB  1 
ATOM   760  C CG  . TYR A 1 157 ? 148.697 174.352 148.217 1.00 20.59  ? 157 TYR A CG  1 
ATOM   761  C CD1 . TYR A 1 157 ? 147.990 175.513 147.963 1.00 20.59  ? 157 TYR A CD1 1 
ATOM   762  C CD2 . TYR A 1 157 ? 147.978 173.190 148.469 1.00 20.59  ? 157 TYR A CD2 1 
ATOM   763  C CE1 . TYR A 1 157 ? 146.613 175.520 147.951 1.00 20.59  ? 157 TYR A CE1 1 
ATOM   764  C CE2 . TYR A 1 157 ? 146.600 173.190 148.466 1.00 20.59  ? 157 TYR A CE2 1 
ATOM   765  C CZ  . TYR A 1 157 ? 145.923 174.359 148.207 1.00 20.59  ? 157 TYR A CZ  1 
ATOM   766  O OH  . TYR A 1 157 ? 144.549 174.366 148.198 1.00 20.59  ? 157 TYR A OH  1 
ATOM   767  N N   . ILE A 1 158 ? 150.130 173.512 151.291 1.00 22.93  ? 158 ILE A N   1 
ATOM   768  C CA  . ILE A 1 158 ? 149.348 173.187 152.474 1.00 22.93  ? 158 ILE A CA  1 
ATOM   769  C C   . ILE A 1 158 ? 149.881 173.921 153.695 1.00 22.93  ? 158 ILE A C   1 
ATOM   770  O O   . ILE A 1 158 ? 149.179 174.030 154.704 1.00 22.93  ? 158 ILE A O   1 
ATOM   771  C CB  . ILE A 1 158 ? 149.299 171.661 152.692 1.00 22.93  ? 158 ILE A CB  1 
ATOM   772  C CG1 . ILE A 1 158 ? 148.013 171.268 153.418 1.00 22.93  ? 158 ILE A CG1 1 
ATOM   773  C CG2 . ILE A 1 158 ? 150.512 171.171 153.462 1.00 22.93  ? 158 ILE A CG2 1 
ATOM   774  C CD1 . ILE A 1 158 ? 147.661 169.809 153.283 1.00 22.93  ? 158 ILE A CD1 1 
ATOM   775  N N   . ALA A 1 159 ? 151.108 174.441 153.625 1.00 22.61  ? 159 ALA A N   1 
ATOM   776  C CA  . ALA A 1 159 ? 151.606 175.292 154.696 1.00 22.61  ? 159 ALA A CA  1 
ATOM   777  C C   . ALA A 1 159 ? 150.990 176.679 154.620 1.00 22.61  ? 159 ALA A C   1 
ATOM   778  O O   . ALA A 1 159 ? 150.705 177.298 155.651 1.00 22.61  ? 159 ALA A O   1 
ATOM   779  C CB  . ALA A 1 159 ? 153.128 175.377 154.628 1.00 22.61  ? 159 ALA A CB  1 
ATOM   780  N N   . VAL A 1 160 ? 150.780 177.184 153.408 1.00 21.53  ? 160 VAL A N   1 
ATOM   781  C CA  . VAL A 1 160 ? 150.271 178.546 153.251 1.00 21.53  ? 160 VAL A CA  1 
ATOM   782  C C   . VAL A 1 160 ? 148.747 178.576 153.296 1.00 21.53  ? 160 VAL A C   1 
ATOM   783  O O   . VAL A 1 160 ? 148.152 179.249 154.145 1.00 21.53  ? 160 VAL A O   1 
ATOM   784  C CB  . VAL A 1 160 ? 150.815 179.175 151.960 1.00 21.53  ? 160 VAL A CB  1 
ATOM   785  C CG1 . VAL A 1 160 ? 150.105 180.470 151.668 1.00 21.53  ? 160 VAL A CG1 1 
ATOM   786  C CG2 . VAL A 1 160 ? 152.291 179.415 152.119 1.00 21.53  ? 160 VAL A CG2 1 
ATOM   787  N N   . CYS A 1 161 ? 148.092 177.851 152.394 1.00 25.09  ? 161 CYS A N   1 
ATOM   788  C CA  . CYS A 1 161 ? 146.648 177.969 152.249 1.00 25.09  ? 161 CYS A CA  1 
ATOM   789  C C   . CYS A 1 161 ? 145.863 177.305 153.369 1.00 25.09  ? 161 CYS A C   1 
ATOM   790  O O   . CYS A 1 161 ? 144.739 177.738 153.646 1.00 25.09  ? 161 CYS A O   1 
ATOM   791  C CB  . CYS A 1 161 ? 146.199 177.381 150.914 1.00 25.09  ? 161 CYS A CB  1 
ATOM   792  S SG  . CYS A 1 161 ? 144.638 178.054 150.301 1.00 25.09  ? 161 CYS A SG  1 
ATOM   793  N N   . HIS A 1 162 ? 146.405 176.276 154.013 1.00 26.68  ? 162 HIS A N   1 
ATOM   794  C CA  . HIS A 1 162 ? 145.742 175.609 155.135 1.00 26.68  ? 162 HIS A CA  1 
ATOM   795  C C   . HIS A 1 162 ? 146.698 175.527 156.317 1.00 26.68  ? 162 HIS A C   1 
ATOM   796  O O   . HIS A 1 162 ? 147.174 174.443 156.675 1.00 26.68  ? 162 HIS A O   1 
ATOM   797  C CB  . HIS A 1 162 ? 145.250 174.217 154.737 1.00 26.68  ? 162 HIS A CB  1 
ATOM   798  C CG  . HIS A 1 162 ? 144.486 174.188 153.453 1.00 26.68  ? 162 HIS A CG  1 
ATOM   799  N ND1 . HIS A 1 162 ? 143.139 174.470 153.385 1.00 26.68  ? 162 HIS A ND1 1 
ATOM   800  C CD2 . HIS A 1 162 ? 144.875 173.905 152.188 1.00 26.68  ? 162 HIS A CD2 1 
ATOM   801  C CE1 . HIS A 1 162 ? 142.732 174.364 152.133 1.00 26.68  ? 162 HIS A CE1 1 
ATOM   802  N NE2 . HIS A 1 162 ? 143.766 174.022 151.386 1.00 26.68  ? 162 HIS A NE2 1 
ATOM   803  N N   . PRO A 1 163 ? 146.984 176.658 156.966 1.00 26.79  ? 163 PRO A N   1 
ATOM   804  C CA  . PRO A 1 163 ? 147.939 176.632 158.079 1.00 26.79  ? 163 PRO A CA  1 
ATOM   805  C C   . PRO A 1 163 ? 147.374 176.033 159.354 1.00 26.79  ? 163 PRO A C   1 
ATOM   806  O O   . PRO A 1 163 ? 148.155 175.587 160.202 1.00 26.79  ? 163 PRO A O   1 
ATOM   807  C CB  . PRO A 1 163 ? 148.282 178.109 158.265 1.00 26.79  ? 163 PRO A CB  1 
ATOM   808  C CG  . PRO A 1 163 ? 147.016 178.800 157.903 1.00 26.79  ? 163 PRO A CG  1 
ATOM   809  C CD  . PRO A 1 163 ? 146.372 177.988 156.809 1.00 26.79  ? 163 PRO A CD  1 
ATOM   810  N N   . VAL A 1 164 ? 146.051 176.020 159.525 1.00 29.57  ? 164 VAL A N   1 
ATOM   811  C CA  . VAL A 1 164 ? 145.460 175.392 160.702 1.00 29.57  ? 164 VAL A CA  1 
ATOM   812  C C   . VAL A 1 164 ? 145.612 173.873 160.630 1.00 29.57  ? 164 VAL A C   1 
ATOM   813  O O   . VAL A 1 164 ? 145.803 173.205 161.653 1.00 29.57  ? 164 VAL A O   1 
ATOM   814  C CB  . VAL A 1 164 ? 143.990 175.840 160.862 1.00 29.57  ? 164 VAL A CB  1 
ATOM   815  C CG1 . VAL A 1 164 ? 143.157 175.511 159.625 1.00 29.57  ? 164 VAL A CG1 1 
ATOM   816  C CG2 . VAL A 1 164 ? 143.364 175.238 162.114 1.00 29.57  ? 164 VAL A CG2 1 
ATOM   817  N N   . LYS A 1 165 ? 145.562 173.308 159.424 1.00 31.33  ? 165 LYS A N   1 
ATOM   818  C CA  . LYS A 1 165 ? 145.811 171.889 159.227 1.00 31.33  ? 165 LYS A CA  1 
ATOM   819  C C   . LYS A 1 165 ? 147.251 171.584 158.840 1.00 31.33  ? 165 LYS A C   1 
ATOM   820  O O   . LYS A 1 165 ? 147.608 170.407 158.725 1.00 31.33  ? 165 LYS A O   1 
ATOM   821  C CB  . LYS A 1 165 ? 144.861 171.327 158.167 1.00 31.33  ? 165 LYS A CB  1 
ATOM   822  C CG  . LYS A 1 165 ? 143.433 171.824 158.301 1.00 31.33  ? 165 LYS A CG  1 
ATOM   823  C CD  . LYS A 1 165 ? 142.492 171.046 157.400 1.00 31.33  ? 165 LYS A CD  1 
ATOM   824  C CE  . LYS A 1 165 ? 141.054 171.503 157.576 1.00 31.33  ? 165 LYS A CE  1 
ATOM   825  N NZ  . LYS A 1 165 ? 140.811 172.834 156.956 1.00 31.33  ? 165 LYS A NZ  1 
ATOM   826  N N   . ALA A 1 166 ? 148.085 172.608 158.639 1.00 32.39  ? 166 ALA A N   1 
ATOM   827  C CA  . ALA A 1 166 ? 149.499 172.364 158.381 1.00 32.39  ? 166 ALA A CA  1 
ATOM   828  C C   . ALA A 1 166 ? 150.214 171.864 159.626 1.00 32.39  ? 166 ALA A C   1 
ATOM   829  O O   . ALA A 1 166 ? 151.161 171.078 159.519 1.00 32.39  ? 166 ALA A O   1 
ATOM   830  C CB  . ALA A 1 166 ? 150.175 173.631 157.863 1.00 32.39  ? 166 ALA A CB  1 
ATOM   831  N N   . LEU A 1 167 ? 149.768 172.296 160.809 1.00 33.42  ? 167 LEU A N   1 
ATOM   832  C CA  . LEU A 1 167 ? 150.360 171.826 162.057 1.00 33.42  ? 167 LEU A CA  1 
ATOM   833  C C   . LEU A 1 167 ? 150.105 170.340 162.279 1.00 33.42  ? 167 LEU A C   1 
ATOM   834  O O   . LEU A 1 167 ? 150.863 169.684 163.002 1.00 33.42  ? 167 LEU A O   1 
ATOM   835  C CB  . LEU A 1 167 ? 149.810 172.635 163.230 1.00 33.42  ? 167 LEU A CB  1 
ATOM   836  C CG  . LEU A 1 167 ? 149.730 174.151 163.043 1.00 33.42  ? 167 LEU A CG  1 
ATOM   837  C CD1 . LEU A 1 167 ? 148.940 174.790 164.172 1.00 33.42  ? 167 LEU A CD1 1 
ATOM   838  C CD2 . LEU A 1 167 ? 151.125 174.745 162.963 1.00 33.42  ? 167 LEU A CD2 1 
ATOM   839  N N   . ASP A 1 168 ? 149.050 169.797 161.675 1.00 38.21  ? 168 ASP A N   1 
ATOM   840  C CA  . ASP A 1 168 ? 148.748 168.377 161.783 1.00 38.21  ? 168 ASP A CA  1 
ATOM   841  C C   . ASP A 1 168 ? 149.288 167.568 160.612 1.00 38.21  ? 168 ASP A C   1 
ATOM   842  O O   . ASP A 1 168 ? 149.704 166.420 160.804 1.00 38.21  ? 168 ASP A O   1 
ATOM   843  C CB  . ASP A 1 168 ? 147.236 168.172 161.887 1.00 38.21  ? 168 ASP A CB  1 
ATOM   844  C CG  . ASP A 1 168 ? 146.659 168.748 163.163 1.00 38.21  ? 168 ASP A CG  1 
ATOM   845  O OD1 . ASP A 1 168 ? 147.385 168.790 164.178 1.00 38.21  ? 168 ASP A OD1 1 
ATOM   846  O OD2 . ASP A 1 168 ? 145.482 169.164 163.151 1.00 38.21  ? 168 ASP A OD2 1 
ATOM   847  N N   . PHE A 1 169 ? 149.299 168.136 159.407 1.00 39.11  ? 169 PHE A N   1 
ATOM   848  C CA  . PHE A 1 169 ? 149.736 167.422 158.216 1.00 39.11  ? 169 PHE A CA  1 
ATOM   849  C C   . PHE A 1 169 ? 151.206 167.657 157.896 1.00 39.11  ? 169 PHE A C   1 
ATOM   850  O O   . PHE A 1 169 ? 151.686 167.182 156.862 1.00 39.11  ? 169 PHE A O   1 
ATOM   851  C CB  . PHE A 1 169 ? 148.882 167.820 157.007 1.00 39.11  ? 169 PHE A CB  1 
ATOM   852  C CG  . PHE A 1 169 ? 147.511 167.195 156.984 1.00 39.11  ? 169 PHE A CG  1 
ATOM   853  C CD1 . PHE A 1 169 ? 147.111 166.304 157.967 1.00 39.11  ? 169 PHE A CD1 1 
ATOM   854  C CD2 . PHE A 1 169 ? 146.626 167.495 155.961 1.00 39.11  ? 169 PHE A CD2 1 
ATOM   855  C CE1 . PHE A 1 169 ? 145.849 165.736 157.937 1.00 39.11  ? 169 PHE A CE1 1 
ATOM   856  C CE2 . PHE A 1 169 ? 145.366 166.928 155.922 1.00 39.11  ? 169 PHE A CE2 1 
ATOM   857  C CZ  . PHE A 1 169 ? 144.977 166.049 156.911 1.00 39.11  ? 169 PHE A CZ  1 
ATOM   858  N N   . ARG A 1 170 ? 151.930 168.383 158.748 1.00 40.29  ? 170 ARG A N   1 
ATOM   859  C CA  . ARG A 1 170 ? 153.336 168.680 158.506 1.00 40.29  ? 170 ARG A CA  1 
ATOM   860  C C   . ARG A 1 170 ? 154.215 168.162 159.637 1.00 40.29  ? 170 ARG A C   1 
ATOM   861  O O   . ARG A 1 170 ? 155.280 168.722 159.909 1.00 40.29  ? 170 ARG A O   1 
ATOM   862  C CB  . ARG A 1 170 ? 153.548 170.180 158.308 1.00 40.29  ? 170 ARG A CB  1 
ATOM   863  C CG  . ARG A 1 170 ? 153.164 170.683 156.928 1.00 40.29  ? 170 ARG A CG  1 
ATOM   864  C CD  . ARG A 1 170 ? 153.661 172.100 156.703 1.00 40.29  ? 170 ARG A CD  1 
ATOM   865  N NE  . ARG A 1 170 ? 155.107 172.162 156.531 1.00 40.29  ? 170 ARG A NE  1 
ATOM   866  C CZ  . ARG A 1 170 ? 155.878 173.120 157.026 1.00 40.29  ? 170 ARG A CZ  1 
ATOM   867  N NH1 . ARG A 1 170 ? 155.375 174.107 157.749 1.00 40.29  ? 170 ARG A NH1 1 
ATOM   868  N NH2 . ARG A 1 170 ? 157.186 173.089 156.789 1.00 40.29  ? 170 ARG A NH2 1 
ATOM   869  N N   . THR A 1 171 ? 153.776 167.105 160.313 1.00 49.07  ? 171 THR A N   1 
ATOM   870  C CA  . THR A 1 171 ? 154.612 166.460 161.309 1.00 49.07  ? 171 THR A CA  1 
ATOM   871  C C   . THR A 1 171 ? 155.790 165.762 160.626 1.00 49.07  ? 171 THR A C   1 
ATOM   872  O O   . THR A 1 171 ? 155.672 165.314 159.482 1.00 49.07  ? 171 THR A O   1 
ATOM   873  C CB  . THR A 1 171 ? 153.801 165.447 162.117 1.00 49.07  ? 171 THR A CB  1 
ATOM   874  O OG1 . THR A 1 171 ? 152.955 164.694 161.240 1.00 49.07  ? 171 THR A OG1 1 
ATOM   875  C CG2 . THR A 1 171 ? 152.942 166.158 163.152 1.00 49.07  ? 171 THR A CG2 1 
ATOM   876  N N   . PRO A 1 172 ? 156.949 165.698 161.292 1.00 52.09  ? 172 PRO A N   1 
ATOM   877  C CA  . PRO A 1 172 ? 158.092 164.975 160.705 1.00 52.09  ? 172 PRO A CA  1 
ATOM   878  C C   . PRO A 1 172 ? 157.826 163.498 160.474 1.00 52.09  ? 172 PRO A C   1 
ATOM   879  O O   . PRO A 1 172 ? 158.359 162.928 159.514 1.00 52.09  ? 172 PRO A O   1 
ATOM   880  C CB  . PRO A 1 172 ? 159.213 165.194 161.731 1.00 52.09  ? 172 PRO A CB  1 
ATOM   881  C CG  . PRO A 1 172 ? 158.519 165.599 162.992 1.00 52.09  ? 172 PRO A CG  1 
ATOM   882  C CD  . PRO A 1 172 ? 157.305 166.352 162.562 1.00 52.09  ? 172 PRO A CD  1 
ATOM   883  N N   . LEU A 1 173 ? 157.004 162.867 161.317 1.00 53.95  ? 173 LEU A N   1 
ATOM   884  C CA  . LEU A 1 173 ? 156.618 161.477 161.092 1.00 53.95  ? 173 LEU A CA  1 
ATOM   885  C C   . LEU A 1 173 ? 155.836 161.321 159.792 1.00 53.95  ? 173 LEU A C   1 
ATOM   886  O O   . LEU A 1 173 ? 156.104 160.406 159.005 1.00 53.95  ? 173 LEU A O   1 
ATOM   887  C CB  . LEU A 1 173 ? 155.807 160.970 162.285 1.00 53.95  ? 173 LEU A CB  1 
ATOM   888  C CG  . LEU A 1 173 ? 155.460 159.484 162.400 1.00 53.95  ? 173 LEU A CG  1 
ATOM   889  C CD1 . LEU A 1 173 ? 155.575 159.039 163.848 1.00 53.95  ? 173 LEU A CD1 1 
ATOM   890  C CD2 . LEU A 1 173 ? 154.052 159.210 161.892 1.00 53.95  ? 173 LEU A CD2 1 
ATOM   891  N N   . LYS A 1 174 ? 154.879 162.219 159.537 1.00 52.50  ? 174 LYS A N   1 
ATOM   892  C CA  . LYS A 1 174 ? 154.114 162.148 158.296 1.00 52.50  ? 174 LYS A CA  1 
ATOM   893  C C   . LYS A 1 174 ? 154.966 162.526 157.092 1.00 52.50  ? 174 LYS A C   1 
ATOM   894  O O   . LYS A 1 174 ? 154.759 161.990 155.996 1.00 52.50  ? 174 LYS A O   1 
ATOM   895  C CB  . LYS A 1 174 ? 152.875 163.039 158.390 1.00 52.50  ? 174 LYS A CB  1 
ATOM   896  C CG  . LYS A 1 174 ? 151.890 162.862 157.245 1.00 52.50  ? 174 LYS A CG  1 
ATOM   897  C CD  . LYS A 1 174 ? 150.633 163.684 157.460 1.00 52.50  ? 174 LYS A CD  1 
ATOM   898  C CE  . LYS A 1 174 ? 149.779 163.095 158.570 1.00 52.50  ? 174 LYS A CE  1 
ATOM   899  N NZ  . LYS A 1 174 ? 149.205 161.776 158.185 1.00 52.50  ? 174 LYS A NZ  1 
ATOM   900  N N   . ALA A 1 175 ? 155.933 163.430 157.277 1.00 53.26  ? 175 ALA A N   1 
ATOM   901  C CA  . ALA A 1 175 ? 156.880 163.735 156.208 1.00 53.26  ? 175 ALA A CA  1 
ATOM   902  C C   . ALA A 1 175 ? 157.716 162.513 155.845 1.00 53.26  ? 175 ALA A C   1 
ATOM   903  O O   . ALA A 1 175 ? 157.921 162.220 154.661 1.00 53.26  ? 175 ALA A O   1 
ATOM   904  C CB  . ALA A 1 175 ? 157.780 164.899 156.619 1.00 53.26  ? 175 ALA A CB  1 
ATOM   905  N N   . LYS A 1 176 ? 158.189 161.777 156.856 1.00 56.81  ? 176 LYS A N   1 
ATOM   906  C CA  . LYS A 1 176 ? 158.916 160.535 156.608 1.00 56.81  ? 176 LYS A CA  1 
ATOM   907  C C   . LYS A 1 176 ? 158.028 159.493 155.941 1.00 56.81  ? 176 LYS A C   1 
ATOM   908  O O   . LYS A 1 176 ? 158.487 158.748 155.071 1.00 56.81  ? 176 LYS A O   1 
ATOM   909  C CB  . LYS A 1 176 ? 159.484 159.984 157.916 1.00 56.81  ? 176 LYS A CB  1 
ATOM   910  C CG  . LYS A 1 176 ? 160.633 160.786 158.501 1.00 56.81  ? 176 LYS A CG  1 
ATOM   911  C CD  . LYS A 1 176 ? 161.922 160.558 157.733 1.00 56.81  ? 176 LYS A CD  1 
ATOM   912  C CE  . LYS A 1 176 ? 163.073 161.324 158.366 1.00 56.81  ? 176 LYS A CE  1 
ATOM   913  N NZ  . LYS A 1 176 ? 163.417 160.790 159.714 1.00 56.81  ? 176 LYS A NZ  1 
ATOM   914  N N   . ILE A 1 177 ? 156.755 159.421 156.345 1.00 55.93  ? 177 ILE A N   1 
ATOM   915  C CA  . ILE A 1 177 ? 155.823 158.466 155.746 1.00 55.93  ? 177 ILE A CA  1 
ATOM   916  C C   . ILE A 1 177 ? 155.620 158.763 154.263 1.00 55.93  ? 177 ILE A C   1 
ATOM   917  O O   . ILE A 1 177 ? 155.686 157.860 153.418 1.00 55.93  ? 177 ILE A O   1 
ATOM   918  C CB  . ILE A 1 177 ? 154.488 158.477 156.517 1.00 55.93  ? 177 ILE A CB  1 
ATOM   919  C CG1 . ILE A 1 177 ? 154.625 157.709 157.832 1.00 55.93  ? 177 ILE A CG1 1 
ATOM   920  C CG2 . ILE A 1 177 ? 153.356 157.898 155.675 1.00 55.93  ? 177 ILE A CG2 1 
ATOM   921  C CD1 . ILE A 1 177 ? 153.332 157.593 158.609 1.00 55.93  ? 177 ILE A CD1 1 
ATOM   922  N N   . ILE A 1 178 ? 155.394 160.035 153.925 1.00 57.28  ? 178 ILE A N   1 
ATOM   923  C CA  . ILE A 1 178 ? 155.198 160.427 152.531 1.00 57.28  ? 178 ILE A CA  1 
ATOM   924  C C   . ILE A 1 178 ? 156.479 160.208 151.730 1.00 57.28  ? 178 ILE A C   1 
ATOM   925  O O   . ILE A 1 178 ? 156.440 159.770 150.570 1.00 57.28  ? 178 ILE A O   1 
ATOM   926  C CB  . ILE A 1 178 ? 154.708 161.888 152.468 1.00 57.28  ? 178 ILE A CB  1 
ATOM   927  C CG1 . ILE A 1 178 ? 153.254 161.978 152.935 1.00 57.28  ? 178 ILE A CG1 1 
ATOM   928  C CG2 . ILE A 1 178 ? 154.831 162.468 151.065 1.00 57.28  ? 178 ILE A CG2 1 
ATOM   929  C CD1 . ILE A 1 178 ? 152.284 161.196 152.077 1.00 57.28  ? 178 ILE A CD1 1 
ATOM   930  N N   . ASN A 1 179 ? 157.634 160.471 152.348 1.00 59.50  ? 179 ASN A N   1 
ATOM   931  C CA  . ASN A 1 179 ? 158.911 160.251 151.678 1.00 59.50  ? 179 ASN A CA  1 
ATOM   932  C C   . ASN A 1 179 ? 159.140 158.772 151.381 1.00 59.50  ? 179 ASN A C   1 
ATOM   933  O O   . ASN A 1 179 ? 159.584 158.416 150.287 1.00 59.50  ? 179 ASN A O   1 
ATOM   934  C CB  . ASN A 1 179 ? 160.044 160.814 152.530 1.00 59.50  ? 179 ASN A CB  1 
ATOM   935  C CG  . ASN A 1 179 ? 161.336 160.933 151.764 1.00 59.50  ? 179 ASN A CG  1 
ATOM   936  O OD1 . ASN A 1 179 ? 161.370 160.741 150.549 1.00 59.50  ? 179 ASN A OD1 1 
ATOM   937  N ND2 . ASN A 1 179 ? 162.412 161.272 152.464 1.00 59.50  ? 179 ASN A ND2 1 
ATOM   938  N N   . ILE A 1 180 ? 158.830 157.895 152.339 1.00 61.32  ? 180 ILE A N   1 
ATOM   939  C CA  . ILE A 1 180 ? 158.972 156.458 152.111 1.00 61.32  ? 180 ILE A CA  1 
ATOM   940  C C   . ILE A 1 180 ? 157.981 155.982 151.052 1.00 61.32  ? 180 ILE A C   1 
ATOM   941  O O   . ILE A 1 180 ? 158.302 155.115 150.228 1.00 61.32  ? 180 ILE A O   1 
ATOM   942  C CB  . ILE A 1 180 ? 158.821 155.691 153.442 1.00 61.32  ? 180 ILE A CB  1 
ATOM   943  C CG1 . ILE A 1 180 ? 159.990 156.009 154.375 1.00 61.32  ? 180 ILE A CG1 1 
ATOM   944  C CG2 . ILE A 1 180 ? 158.744 154.187 153.227 1.00 61.32  ? 180 ILE A CG2 1 
ATOM   945  C CD1 . ILE A 1 180 ? 161.338 155.635 153.808 1.00 61.32  ? 180 ILE A CD1 1 
ATOM   946  N N   . CYS A 1 181 ? 156.775 156.562 151.035 1.00 61.97  ? 181 CYS A N   1 
ATOM   947  C CA  . CYS A 1 181 ? 155.791 156.200 150.017 1.00 61.97  ? 181 CYS A CA  1 
ATOM   948  C C   . CYS A 1 181 ? 156.271 156.562 148.614 1.00 61.97  ? 181 CYS A C   1 
ATOM   949  O O   . CYS A 1 181 ? 156.176 155.746 147.688 1.00 61.97  ? 181 CYS A O   1 
ATOM   950  C CB  . CYS A 1 181 ? 154.456 156.879 150.314 1.00 61.97  ? 181 CYS A CB  1 
ATOM   951  S SG  . CYS A 1 181 ? 153.097 156.336 149.254 1.00 61.97  ? 181 CYS A SG  1 
ATOM   952  N N   . ILE A 1 182 ? 156.815 157.770 148.440 1.00 60.08  ? 182 ILE A N   1 
ATOM   953  C CA  . ILE A 1 182 ? 157.296 158.140 147.111 1.00 60.08  ? 182 ILE A CA  1 
ATOM   954  C C   . ILE A 1 182 ? 158.598 157.413 146.782 1.00 60.08  ? 182 ILE A C   1 
ATOM   955  O O   . ILE A 1 182 ? 158.894 157.165 145.605 1.00 60.08  ? 182 ILE A O   1 
ATOM   956  C CB  . ILE A 1 182 ? 157.430 159.670 146.969 1.00 60.08  ? 182 ILE A CB  1 
ATOM   957  C CG1 . ILE A 1 182 ? 158.574 160.223 147.819 1.00 60.08  ? 182 ILE A CG1 1 
ATOM   958  C CG2 . ILE A 1 182 ? 156.112 160.355 147.312 1.00 60.08  ? 182 ILE A CG2 1 
ATOM   959  C CD1 . ILE A 1 182 ? 158.794 161.708 147.646 1.00 60.08  ? 182 ILE A CD1 1 
ATOM   960  N N   . TRP A 1 183 ? 159.372 157.021 147.803 1.00 62.23  ? 183 TRP A N   1 
ATOM   961  C CA  . TRP A 1 183 ? 160.547 156.187 147.571 1.00 62.23  ? 183 TRP A CA  1 
ATOM   962  C C   . TRP A 1 183 ? 160.146 154.826 147.019 1.00 62.23  ? 183 TRP A C   1 
ATOM   963  O O   . TRP A 1 183 ? 160.767 154.325 146.078 1.00 62.23  ? 183 TRP A O   1 
ATOM   964  C CB  . TRP A 1 183 ? 161.341 156.004 148.867 1.00 62.23  ? 183 TRP A CB  1 
ATOM   965  C CG  . TRP A 1 183 ? 162.401 157.045 149.161 1.00 62.23  ? 183 TRP A CG  1 
ATOM   966  C CD1 . TRP A 1 183 ? 162.529 157.772 150.310 1.00 62.23  ? 183 TRP A CD1 1 
ATOM   967  C CD2 . TRP A 1 183 ? 163.469 157.472 148.302 1.00 62.23  ? 183 TRP A CD2 1 
ATOM   968  N NE1 . TRP A 1 183 ? 163.605 158.617 150.223 1.00 62.23  ? 183 TRP A NE1 1 
ATOM   969  C CE2 . TRP A 1 183 ? 164.199 158.454 149.000 1.00 62.23  ? 183 TRP A CE2 1 
ATOM   970  C CE3 . TRP A 1 183 ? 163.880 157.122 147.014 1.00 62.23  ? 183 TRP A CE3 1 
ATOM   971  C CZ2 . TRP A 1 183 ? 165.312 159.085 148.454 1.00 62.23  ? 183 TRP A CZ2 1 
ATOM   972  C CZ3 . TRP A 1 183 ? 164.984 157.750 146.477 1.00 62.23  ? 183 TRP A CZ3 1 
ATOM   973  C CH2 . TRP A 1 183 ? 165.689 158.718 147.195 1.00 62.23  ? 183 TRP A CH2 1 
ATOM   974  N N   . LEU A 1 184 ? 159.098 154.226 147.587 1.00 65.22  ? 184 LEU A N   1 
ATOM   975  C CA  . LEU A 1 184 ? 158.602 152.946 147.091 1.00 65.22  ? 184 LEU A CA  1 
ATOM   976  C C   . LEU A 1 184 ? 157.983 153.090 145.705 1.00 65.22  ? 184 LEU A C   1 
ATOM   977  O O   . LEU A 1 184 ? 158.104 152.190 144.863 1.00 65.22  ? 184 LEU A O   1 
ATOM   978  C CB  . LEU A 1 184 ? 157.588 152.368 148.077 1.00 65.22  ? 184 LEU A CB  1 
ATOM   979  C CG  . LEU A 1 184 ? 156.991 150.997 147.755 1.00 65.22  ? 184 LEU A CG  1 
ATOM   980  C CD1 . LEU A 1 184 ? 158.075 149.931 147.727 1.00 65.22  ? 184 LEU A CD1 1 
ATOM   981  C CD2 . LEU A 1 184 ? 155.904 150.637 148.756 1.00 65.22  ? 184 LEU A CD2 1 
ATOM   982  N N   . LEU A 1 185 ? 157.311 154.219 145.454 1.00 63.46  ? 185 LEU A N   1 
ATOM   983  C CA  . LEU A 1 185 ? 156.727 154.460 144.136 1.00 63.46  ? 185 LEU A CA  1 
ATOM   984  C C   . LEU A 1 185 ? 157.804 154.592 143.065 1.00 63.46  ? 185 LEU A C   1 
ATOM   985  O O   . LEU A 1 185 ? 157.636 154.102 141.942 1.00 63.46  ? 185 LEU A O   1 
ATOM   986  C CB  . LEU A 1 185 ? 155.845 155.707 144.174 1.00 63.46  ? 185 LEU A CB  1 
ATOM   987  C CG  . LEU A 1 185 ? 155.070 156.023 142.895 1.00 63.46  ? 185 LEU A CG  1 
ATOM   988  C CD1 . LEU A 1 185 ? 154.108 154.897 142.561 1.00 63.46  ? 185 LEU A CD1 1 
ATOM   989  C CD2 . LEU A 1 185 ? 154.323 157.337 143.043 1.00 63.46  ? 185 LEU A CD2 1 
ATOM   990  N N   . SER A 1 186 ? 158.918 155.254 143.390 1.00 63.18  ? 186 SER A N   1 
ATOM   991  C CA  . SER A 1 186 ? 160.051 155.280 142.469 1.00 63.18  ? 186 SER A CA  1 
ATOM   992  C C   . SER A 1 186 ? 160.723 153.915 142.364 1.00 63.18  ? 186 SER A C   1 
ATOM   993  O O   . SER A 1 186 ? 161.197 153.536 141.285 1.00 63.18  ? 186 SER A O   1 
ATOM   994  C CB  . SER A 1 186 ? 161.063 156.335 142.913 1.00 63.18  ? 186 SER A CB  1 
ATOM   995  O OG  . SER A 1 186 ? 161.288 156.267 144.309 1.00 63.18  ? 186 SER A OG  1 
ATOM   996  N N   . SER A 1 187 ? 160.770 153.164 143.468 1.00 67.65  ? 187 SER A N   1 
ATOM   997  C CA  . SER A 1 187 ? 161.433 151.868 143.480 1.00 67.65  ? 187 SER A CA  1 
ATOM   998  C C   . SER A 1 187 ? 160.694 150.824 142.658 1.00 67.65  ? 187 SER A C   1 
ATOM   999  O O   . SER A 1 187 ? 161.332 149.898 142.152 1.00 67.65  ? 187 SER A O   1 
ATOM   1000 C CB  . SER A 1 187 ? 161.592 151.377 144.919 1.00 67.65  ? 187 SER A CB  1 
ATOM   1001 O OG  . SER A 1 187 ? 162.297 152.323 145.704 1.00 67.65  ? 187 SER A OG  1 
ATOM   1002 N N   . SER A 1 188 ? 159.371 150.943 142.526 1.00 69.38  ? 188 SER A N   1 
ATOM   1003 C CA  . SER A 1 188 ? 158.633 150.033 141.649 1.00 69.38  ? 188 SER A CA  1 
ATOM   1004 C C   . SER A 1 188 ? 159.064 150.209 140.195 1.00 69.38  ? 188 SER A C   1 
ATOM   1005 O O   . SER A 1 188 ? 159.298 149.228 139.476 1.00 69.38  ? 188 SER A O   1 
ATOM   1006 C CB  . SER A 1 188 ? 157.128 150.259 141.797 1.00 69.38  ? 188 SER A CB  1 
ATOM   1007 O OG  . SER A 1 188 ? 156.692 151.339 140.992 1.00 69.38  ? 188 SER A OG  1 
ATOM   1008 N N   . VAL A 1 189 ? 159.200 151.461 139.754 1.00 67.59  ? 189 VAL A N   1 
ATOM   1009 C CA  . VAL A 1 189 ? 159.698 151.737 138.410 1.00 67.59  ? 189 VAL A CA  1 
ATOM   1010 C C   . VAL A 1 189 ? 161.151 151.294 138.279 1.00 67.59  ? 189 VAL A C   1 
ATOM   1011 O O   . VAL A 1 189 ? 161.565 150.770 137.236 1.00 67.59  ? 189 VAL A O   1 
ATOM   1012 C CB  . VAL A 1 189 ? 159.516 153.230 138.082 1.00 67.59  ? 189 VAL A CB  1 
ATOM   1013 C CG1 . VAL A 1 189 ? 160.067 153.563 136.702 1.00 67.59  ? 189 VAL A CG1 1 
ATOM   1014 C CG2 . VAL A 1 189 ? 158.049 153.612 138.180 1.00 67.59  ? 189 VAL A CG2 1 
ATOM   1015 N N   . GLY A 1 190 ? 161.939 151.470 139.345 1.00 70.36  ? 190 GLY A N   1 
ATOM   1016 C CA  . GLY A 1 190 ? 163.329 151.038 139.311 1.00 70.36  ? 190 GLY A CA  1 
ATOM   1017 C C   . GLY A 1 190 ? 163.487 149.534 139.162 1.00 70.36  ? 190 GLY A C   1 
ATOM   1018 O O   . GLY A 1 190 ? 164.310 149.063 138.372 1.00 70.36  ? 190 GLY A O   1 
ATOM   1019 N N   . ILE A 1 191 ? 162.692 148.760 139.904 1.00 72.78  ? 191 ILE A N   1 
ATOM   1020 C CA  . ILE A 1 191 ? 162.787 147.308 139.781 1.00 72.78  ? 191 ILE A CA  1 
ATOM   1021 C C   . ILE A 1 191 ? 162.180 146.827 138.465 1.00 72.78  ? 191 ILE A C   1 
ATOM   1022 O O   . ILE A 1 191 ? 162.649 145.832 137.900 1.00 72.78  ? 191 ILE A O   1 
ATOM   1023 C CB  . ILE A 1 191 ? 162.170 146.585 140.995 1.00 72.78  ? 191 ILE A CB  1 
ATOM   1024 C CG1 . ILE A 1 191 ? 160.668 146.844 141.114 1.00 72.78  ? 191 ILE A CG1 1 
ATOM   1025 C CG2 . ILE A 1 191 ? 162.896 146.980 142.272 1.00 72.78  ? 191 ILE A CG2 1 
ATOM   1026 C CD1 . ILE A 1 191 ? 159.974 145.961 142.126 1.00 72.78  ? 191 ILE A CD1 1 
ATOM   1027 N N   . SER A 1 192 ? 161.165 147.521 137.934 1.00 72.07  ? 192 SER A N   1 
ATOM   1028 C CA  . SER A 1 192 ? 160.679 147.190 136.597 1.00 72.07  ? 192 SER A CA  1 
ATOM   1029 C C   . SER A 1 192 ? 161.762 147.418 135.550 1.00 72.07  ? 192 SER A C   1 
ATOM   1030 O O   . SER A 1 192 ? 161.921 146.616 134.621 1.00 72.07  ? 192 SER A O   1 
ATOM   1031 C CB  . SER A 1 192 ? 159.434 148.012 136.269 1.00 72.07  ? 192 SER A CB  1 
ATOM   1032 O OG  . SER A 1 192 ? 159.777 149.352 135.965 1.00 72.07  ? 192 SER A OG  1 
ATOM   1033 N N   . ALA A 1 193 ? 162.530 148.500 135.700 1.00 72.79  ? 193 ALA A N   1 
ATOM   1034 C CA  . ALA A 1 193 ? 163.645 148.760 134.797 1.00 72.79  ? 193 ALA A CA  1 
ATOM   1035 C C   . ALA A 1 193 ? 164.745 147.714 134.947 1.00 72.79  ? 193 ALA A C   1 
ATOM   1036 O O   . ALA A 1 193 ? 165.353 147.301 133.952 1.00 72.79  ? 193 ALA A O   1 
ATOM   1037 C CB  . ALA A 1 193 ? 164.203 150.160 135.044 1.00 72.79  ? 193 ALA A CB  1 
ATOM   1038 N N   . ILE A 1 194 ? 165.019 147.277 136.179 1.00 69.19  ? 194 ILE A N   1 
ATOM   1039 C CA  . ILE A 1 194 ? 166.110 146.330 136.381 1.00 69.19  ? 194 ILE A CA  1 
ATOM   1040 C C   . ILE A 1 194 ? 165.709 144.918 135.954 1.00 69.19  ? 194 ILE A C   1 
ATOM   1041 O O   . ILE A 1 194 ? 166.583 144.093 135.670 1.00 69.19  ? 194 ILE A O   1 
ATOM   1042 C CB  . ILE A 1 194 ? 166.603 146.373 137.844 1.00 69.19  ? 194 ILE A CB  1 
ATOM   1043 C CG1 . ILE A 1 194 ? 168.038 145.865 137.953 1.00 69.19  ? 194 ILE A CG1 1 
ATOM   1044 C CG2 . ILE A 1 194 ? 165.770 145.488 138.739 1.00 69.19  ? 194 ILE A CG2 1 
ATOM   1045 C CD1 . ILE A 1 194 ? 168.681 146.144 139.293 1.00 69.19  ? 194 ILE A CD1 1 
ATOM   1046 N N   . VAL A 1 195 ? 164.409 144.609 135.880 1.00 72.08  ? 195 VAL A N   1 
ATOM   1047 C CA  . VAL A 1 195 ? 163.990 143.308 135.359 1.00 72.08  ? 195 VAL A CA  1 
ATOM   1048 C C   . VAL A 1 195 ? 163.636 143.345 133.877 1.00 72.08  ? 195 VAL A C   1 
ATOM   1049 O O   . VAL A 1 195 ? 163.501 142.274 133.262 1.00 72.08  ? 195 VAL A O   1 
ATOM   1050 C CB  . VAL A 1 195 ? 162.809 142.713 136.158 1.00 72.08  ? 195 VAL A CB  1 
ATOM   1051 C CG1 . VAL A 1 195 ? 163.149 142.631 137.640 1.00 72.08  ? 195 VAL A CG1 1 
ATOM   1052 C CG2 . VAL A 1 195 ? 161.538 143.510 135.929 1.00 72.08  ? 195 VAL A CG2 1 
ATOM   1053 N N   . LEU A 1 196 ? 163.487 144.527 133.280 1.00 71.97  ? 196 LEU A N   1 
ATOM   1054 C CA  . LEU A 1 196 ? 163.330 144.662 131.833 1.00 71.97  ? 196 LEU A CA  1 
ATOM   1055 C C   . LEU A 1 196 ? 164.538 145.348 131.200 1.00 71.97  ? 196 LEU A C   1 
ATOM   1056 O O   . LEU A 1 196 ? 164.403 146.154 130.279 1.00 71.97  ? 196 LEU A O   1 
ATOM   1057 C CB  . LEU A 1 196 ? 162.049 145.415 131.479 1.00 71.97  ? 196 LEU A CB  1 
ATOM   1058 C CG  . LEU A 1 196 ? 160.757 144.611 131.290 1.00 71.97  ? 196 LEU A CG  1 
ATOM   1059 C CD1 . LEU A 1 196 ? 160.158 144.154 132.604 1.00 71.97  ? 196 LEU A CD1 1 
ATOM   1060 C CD2 . LEU A 1 196 ? 159.739 145.415 130.493 1.00 71.97  ? 196 LEU A CD2 1 
ATOM   1061 N N   . GLY A 1 197 ? 165.737 145.029 131.688 1.00 74.73  ? 197 GLY A N   1 
ATOM   1062 C CA  . GLY A 1 197 ? 166.961 145.554 131.127 1.00 74.73  ? 197 GLY A CA  1 
ATOM   1063 C C   . GLY A 1 197 ? 167.677 144.525 130.263 1.00 74.73  ? 197 GLY A C   1 
ATOM   1064 O O   . GLY A 1 197 ? 167.388 143.332 130.296 1.00 74.73  ? 197 GLY A O   1 
ATOM   1065 N N   . GLY A 1 198 ? 168.623 145.017 129.480 1.00 80.95  ? 198 GLY A N   1 
ATOM   1066 C CA  . GLY A 1 198 ? 169.374 144.160 128.587 1.00 80.95  ? 198 GLY A CA  1 
ATOM   1067 C C   . GLY A 1 198 ? 170.002 144.968 127.474 1.00 80.95  ? 198 GLY A C   1 
ATOM   1068 O O   . GLY A 1 198 ? 169.796 146.175 127.356 1.00 80.95  ? 198 GLY A O   1 
ATOM   1069 N N   . THR A 1 199 ? 170.773 144.266 126.646 1.00 88.64  ? 199 THR A N   1 
ATOM   1070 C CA  . THR A 1 199 ? 171.507 144.894 125.558 1.00 88.64  ? 199 THR A CA  1 
ATOM   1071 C C   . THR A 1 199 ? 171.303 144.116 124.266 1.00 88.64  ? 199 THR A C   1 
ATOM   1072 O O   . THR A 1 199 ? 170.911 142.946 124.270 1.00 88.64  ? 199 THR A O   1 
ATOM   1073 C CB  . THR A 1 199 ? 173.009 145.002 125.870 1.00 88.64  ? 199 THR A CB  1 
ATOM   1074 O OG1 . THR A 1 199 ? 173.645 145.829 124.888 1.00 88.64  ? 199 THR A OG1 1 
ATOM   1075 C CG2 . THR A 1 199 ? 173.666 143.631 125.877 1.00 88.64  ? 199 THR A CG2 1 
ATOM   1076 N N   . LYS A 1 200 ? 171.562 144.800 123.153 1.00 97.85  ? 200 LYS A N   1 
ATOM   1077 C CA  . LYS A 1 200 ? 171.501 144.197 121.829 1.00 97.85  ? 200 LYS A CA  1 
ATOM   1078 C C   . LYS A 1 200 ? 172.357 145.025 120.883 1.00 97.85  ? 200 LYS A C   1 
ATOM   1079 O O   . LYS A 1 200 ? 172.737 146.158 121.190 1.00 97.85  ? 200 LYS A O   1 
ATOM   1080 C CB  . LYS A 1 200 ? 170.060 144.095 121.313 1.00 97.85  ? 200 LYS A CB  1 
ATOM   1081 C CG  . LYS A 1 200 ? 169.297 145.407 121.319 1.00 97.85  ? 200 LYS A CG  1 
ATOM   1082 C CD  . LYS A 1 200 ? 167.908 145.240 120.718 1.00 97.85  ? 200 LYS A CD  1 
ATOM   1083 C CE  . LYS A 1 200 ? 167.017 144.383 121.606 1.00 97.85  ? 200 LYS A CE  1 
ATOM   1084 N NZ  . LYS A 1 200 ? 165.637 144.250 121.058 1.00 97.85  ? 200 LYS A NZ  1 
ATOM   1085 N N   . VAL A 1 201 ? 172.658 144.440 119.729 1.00 105.13 ? 201 VAL A N   1 
ATOM   1086 C CA  . VAL A 1 201 ? 173.498 145.088 118.733 1.00 105.13 ? 201 VAL A CA  1 
ATOM   1087 C C   . VAL A 1 201 ? 172.620 145.760 117.685 1.00 105.13 ? 201 VAL A C   1 
ATOM   1088 O O   . VAL A 1 201 ? 171.438 145.444 117.527 1.00 105.13 ? 201 VAL A O   1 
ATOM   1089 C CB  . VAL A 1 201 ? 174.469 144.087 118.074 1.00 105.13 ? 201 VAL A CB  1 
ATOM   1090 C CG1 . VAL A 1 201 ? 175.477 143.568 119.085 1.00 105.13 ? 201 VAL A CG1 1 
ATOM   1091 C CG2 . VAL A 1 201 ? 173.698 142.936 117.442 1.00 105.13 ? 201 VAL A CG2 1 
ATOM   1092 N N   . ARG A 1 202 ? 173.210 146.705 116.961 1.00 107.05 ? 202 ARG A N   1 
ATOM   1093 C CA  . ARG A 1 202 ? 172.596 147.306 115.786 1.00 107.05 ? 202 ARG A CA  1 
ATOM   1094 C C   . ARG A 1 202 ? 173.443 146.997 114.558 1.00 107.05 ? 202 ARG A C   1 
ATOM   1095 O O   . ARG A 1 202 ? 174.671 147.120 114.591 1.00 107.05 ? 202 ARG A O   1 
ATOM   1096 C CB  . ARG A 1 202 ? 172.416 148.819 115.966 1.00 107.05 ? 202 ARG A CB  1 
ATOM   1097 C CG  . ARG A 1 202 ? 173.661 149.584 116.402 1.00 107.05 ? 202 ARG A CG  1 
ATOM   1098 C CD  . ARG A 1 202 ? 173.386 151.079 116.448 1.00 107.05 ? 202 ARG A CD  1 
ATOM   1099 N NE  . ARG A 1 202 ? 172.385 151.415 117.454 1.00 107.05 ? 202 ARG A NE  1 
ATOM   1100 C CZ  . ARG A 1 202 ? 171.849 152.619 117.603 1.00 107.05 ? 202 ARG A CZ  1 
ATOM   1101 N NH1 . ARG A 1 202 ? 172.230 153.643 116.857 1.00 107.05 ? 202 ARG A NH1 1 
ATOM   1102 N NH2 . ARG A 1 202 ? 170.907 152.800 118.525 1.00 107.05 ? 202 ARG A NH2 1 
ATOM   1103 N N   . GLU A 1 203 ? 172.785 146.588 113.477 1.00 112.81 ? 203 GLU A N   1 
ATOM   1104 C CA  . GLU A 1 203 ? 173.491 146.061 112.309 1.00 112.81 ? 203 GLU A CA  1 
ATOM   1105 C C   . GLU A 1 203 ? 173.824 147.149 111.290 1.00 112.81 ? 203 GLU A C   1 
ATOM   1106 O O   . GLU A 1 203 ? 173.540 147.019 110.101 1.00 112.81 ? 203 GLU A O   1 
ATOM   1107 C CB  . GLU A 1 203 ? 172.667 144.950 111.670 1.00 112.81 ? 203 GLU A CB  1 
ATOM   1108 N N   . ASP A 1 204 ? 174.424 148.233 111.755 1.00 115.71 ? 204 ASP A N   1 
ATOM   1109 C CA  . ASP A 1 204 ? 175.102 149.196 110.893 1.00 115.71 ? 204 ASP A CA  1 
ATOM   1110 C C   . ASP A 1 204 ? 176.516 149.484 111.363 1.00 115.71 ? 204 ASP A C   1 
ATOM   1111 O O   . ASP A 1 204 ? 177.418 149.643 110.537 1.00 115.71 ? 204 ASP A O   1 
ATOM   1112 C CB  . ASP A 1 204 ? 174.315 150.516 110.821 1.00 115.71 ? 204 ASP A CB  1 
ATOM   1113 C CG  . ASP A 1 204 ? 173.968 151.065 112.195 1.00 115.71 ? 204 ASP A CG  1 
ATOM   1114 O OD1 . ASP A 1 204 ? 174.106 150.322 113.189 1.00 115.71 ? 204 ASP A OD1 1 
ATOM   1115 O OD2 . ASP A 1 204 ? 173.572 152.246 112.285 1.00 115.71 ? 204 ASP A OD2 1 
ATOM   1116 N N   . VAL A 1 205 ? 176.724 149.557 112.675 1.00 113.96 ? 205 VAL A N   1 
ATOM   1117 C CA  . VAL A 1 205 ? 178.025 149.847 113.261 1.00 113.96 ? 205 VAL A CA  1 
ATOM   1118 C C   . VAL A 1 205 ? 178.468 148.749 114.227 1.00 113.96 ? 205 VAL A C   1 
ATOM   1119 O O   . VAL A 1 205 ? 179.684 148.574 114.437 1.00 113.96 ? 205 VAL A O   1 
ATOM   1120 C CB  . VAL A 1 205 ? 177.987 151.230 113.965 1.00 113.96 ? 205 VAL A CB  1 
ATOM   1121 C CG1 . VAL A 1 205 ? 179.285 151.595 114.666 1.00 113.96 ? 205 VAL A CG1 1 
ATOM   1122 C CG2 . VAL A 1 205 ? 177.620 152.332 112.973 1.00 113.96 ? 205 VAL A CG2 1 
ATOM   1123 N N   . ASP A 1 206 ? 177.525 147.934 114.721 1.00 107.94 ? 206 ASP A N   1 
ATOM   1124 C CA  . ASP A 1 206 ? 177.743 146.873 115.713 1.00 107.94 ? 206 ASP A CA  1 
ATOM   1125 C C   . ASP A 1 206 ? 178.264 147.445 117.030 1.00 107.94 ? 206 ASP A C   1 
ATOM   1126 O O   . ASP A 1 206 ? 179.220 146.942 117.622 1.00 107.94 ? 206 ASP A O   1 
ATOM   1127 C CB  . ASP A 1 206 ? 178.661 145.768 115.180 1.00 107.94 ? 206 ASP A CB  1 
ATOM   1128 C CG  . ASP A 1 206 ? 178.071 145.060 113.981 1.00 107.94 ? 206 ASP A CG  1 
ATOM   1129 O OD1 . ASP A 1 206 ? 177.149 145.631 113.365 1.00 107.94 ? 206 ASP A OD1 1 
ATOM   1130 O OD2 . ASP A 1 206 ? 178.541 143.958 113.633 1.00 107.94 ? 206 ASP A OD2 1 
ATOM   1131 N N   . VAL A 1 207 ? 177.619 148.516 117.482 1.00 96.76  ? 207 VAL A N   1 
ATOM   1132 C CA  . VAL A 1 207 ? 177.805 149.037 118.826 1.00 96.76  ? 207 VAL A CA  1 
ATOM   1133 C C   . VAL A 1 207 ? 176.598 148.629 119.663 1.00 96.76  ? 207 VAL A C   1 
ATOM   1134 O O   . VAL A 1 207 ? 175.616 148.089 119.156 1.00 96.76  ? 207 VAL A O   1 
ATOM   1135 C CB  . VAL A 1 207 ? 178.012 150.562 118.838 1.00 96.76  ? 207 VAL A CB  1 
ATOM   1136 C CG1 . VAL A 1 207 ? 179.407 150.906 118.327 1.00 96.76  ? 207 VAL A CG1 1 
ATOM   1137 C CG2 . VAL A 1 207 ? 176.935 151.247 118.007 1.00 96.76  ? 207 VAL A CG2 1 
ATOM   1138 N N   . ILE A 1 208 ? 176.689 148.869 120.968 1.00 87.34  ? 208 ILE A N   1 
ATOM   1139 C CA  . ILE A 1 208 ? 175.714 148.364 121.926 1.00 87.34  ? 208 ILE A CA  1 
ATOM   1140 C C   . ILE A 1 208 ? 175.307 149.467 122.895 1.00 87.34  ? 208 ILE A C   1 
ATOM   1141 O O   . ILE A 1 208 ? 176.127 150.307 123.281 1.00 87.34  ? 208 ILE A O   1 
ATOM   1142 C CB  . ILE A 1 208 ? 176.267 147.136 122.682 1.00 87.34  ? 208 ILE A CB  1 
ATOM   1143 C CG1 . ILE A 1 208 ? 177.632 147.447 123.296 1.00 87.34  ? 208 ILE A CG1 1 
ATOM   1144 C CG2 . ILE A 1 208 ? 176.348 145.922 121.776 1.00 87.34  ? 208 ILE A CG2 1 
ATOM   1145 C CD1 . ILE A 1 208 ? 178.175 146.330 124.147 1.00 87.34  ? 208 ILE A CD1 1 
ATOM   1146 N N   . GLU A 1 209 ? 174.025 149.470 123.267 1.00 88.77  ? 209 GLU A N   1 
ATOM   1147 C CA  . GLU A 1 209 ? 173.498 150.325 124.322 1.00 88.77  ? 209 GLU A CA  1 
ATOM   1148 C C   . GLU A 1 209 ? 172.393 149.580 125.061 1.00 88.77  ? 209 GLU A C   1 
ATOM   1149 O O   . GLU A 1 209 ? 171.660 148.784 124.470 1.00 88.77  ? 209 GLU A O   1 
ATOM   1150 C CB  . GLU A 1 209 ? 172.989 151.672 123.775 1.00 88.77  ? 209 GLU A CB  1 
ATOM   1151 C CG  . GLU A 1 209 ? 171.755 151.601 122.891 1.00 88.77  ? 209 GLU A CG  1 
ATOM   1152 C CD  . GLU A 1 209 ? 172.095 151.418 121.426 1.00 88.77  ? 209 GLU A CD  1 
ATOM   1153 O OE1 . GLU A 1 209 ? 173.259 151.086 121.120 1.00 88.77  ? 209 GLU A OE1 1 
ATOM   1154 O OE2 . GLU A 1 209 ? 171.198 151.618 120.580 1.00 88.77  ? 209 GLU A OE2 1 
ATOM   1155 N N   . CYS A 1 210 ? 172.295 149.825 126.367 1.00 82.39  ? 210 CYS A N   1 
ATOM   1156 C CA  . CYS A 1 210 ? 171.315 149.154 127.213 1.00 82.39  ? 210 CYS A CA  1 
ATOM   1157 C C   . CYS A 1 210 ? 170.046 149.989 127.324 1.00 82.39  ? 210 CYS A C   1 
ATOM   1158 O O   . CYS A 1 210 ? 170.101 151.176 127.662 1.00 82.39  ? 210 CYS A O   1 
ATOM   1159 C CB  . CYS A 1 210 ? 171.885 148.856 128.606 1.00 82.39  ? 210 CYS A CB  1 
ATOM   1160 S SG  . CYS A 1 210 ? 172.905 147.352 128.664 1.00 82.39  ? 210 CYS A SG  1 
ATOM   1161 N N   . SER A 1 211 ? 168.911 149.356 127.057 1.00 76.62  ? 211 SER A N   1 
ATOM   1162 C CA  . SER A 1 211 ? 167.612 150.014 127.051 1.00 76.62  ? 211 SER A CA  1 
ATOM   1163 C C   . SER A 1 211 ? 166.574 149.004 127.527 1.00 76.62  ? 211 SER A C   1 
ATOM   1164 O O   . SER A 1 211 ? 166.917 147.989 128.141 1.00 76.62  ? 211 SER A O   1 
ATOM   1165 C CB  . SER A 1 211 ? 167.300 150.573 125.653 1.00 76.62  ? 211 SER A CB  1 
ATOM   1166 O OG  . SER A 1 211 ? 166.757 149.564 124.818 1.00 76.62  ? 211 SER A OG  1 
ATOM   1167 N N   . LEU A 1 212 ? 165.303 149.291 127.261 1.00 73.61  ? 212 LEU A N   1 
ATOM   1168 C CA  . LEU A 1 212 ? 164.219 148.410 127.676 1.00 73.61  ? 212 LEU A CA  1 
ATOM   1169 C C   . LEU A 1 212 ? 164.284 147.104 126.892 1.00 73.61  ? 212 LEU A C   1 
ATOM   1170 O O   . LEU A 1 212 ? 164.623 147.101 125.704 1.00 73.61  ? 212 LEU A O   1 
ATOM   1171 C CB  . LEU A 1 212 ? 162.873 149.098 127.466 1.00 73.61  ? 212 LEU A CB  1 
ATOM   1172 C CG  . LEU A 1 212 ? 161.635 148.374 128.001 1.00 73.61  ? 212 LEU A CG  1 
ATOM   1173 C CD1 . LEU A 1 212 ? 161.537 148.556 129.506 1.00 73.61  ? 212 LEU A CD1 1 
ATOM   1174 C CD2 . LEU A 1 212 ? 160.370 148.857 127.314 1.00 73.61  ? 212 LEU A CD2 1 
ATOM   1175 N N   . GLN A 1 213 ? 163.975 145.995 127.560 1.00 72.53  ? 213 GLN A N   1 
ATOM   1176 C CA  . GLN A 1 213 ? 163.965 144.676 126.931 1.00 72.53  ? 213 GLN A CA  1 
ATOM   1177 C C   . GLN A 1 213 ? 162.622 144.487 126.241 1.00 72.53  ? 213 GLN A C   1 
ATOM   1178 O O   . GLN A 1 213 ? 161.625 144.108 126.856 1.00 72.53  ? 213 GLN A O   1 
ATOM   1179 C CB  . GLN A 1 213 ? 164.221 143.584 127.962 1.00 72.53  ? 213 GLN A CB  1 
ATOM   1180 N N   . PHE A 1 214 ? 162.597 144.756 124.942 1.00 84.26  ? 214 PHE A N   1 
ATOM   1181 C CA  . PHE A 1 214 ? 161.385 144.605 124.137 1.00 84.26  ? 214 PHE A CA  1 
ATOM   1182 C C   . PHE A 1 214 ? 161.807 144.220 122.727 1.00 84.26  ? 214 PHE A C   1 
ATOM   1183 O O   . PHE A 1 214 ? 162.180 145.085 121.920 1.00 84.26  ? 214 PHE A O   1 
ATOM   1184 C CB  . PHE A 1 214 ? 160.547 145.880 124.129 1.00 84.26  ? 214 PHE A CB  1 
ATOM   1185 N N   . PRO A 1 215 ? 161.765 142.928 122.389 1.00 90.20  ? 215 PRO A N   1 
ATOM   1186 C CA  . PRO A 1 215 ? 162.192 142.500 121.049 1.00 90.20  ? 215 PRO A CA  1 
ATOM   1187 C C   . PRO A 1 215 ? 161.172 142.834 119.973 1.00 90.20  ? 215 PRO A C   1 
ATOM   1188 O O   . PRO A 1 215 ? 160.126 143.427 120.257 1.00 90.20  ? 215 PRO A O   1 
ATOM   1189 C CB  . PRO A 1 215 ? 162.363 140.981 121.200 1.00 90.20  ? 215 PRO A CB  1 
ATOM   1190 C CG  . PRO A 1 215 ? 162.372 140.723 122.688 1.00 90.20  ? 215 PRO A CG  1 
ATOM   1191 C CD  . PRO A 1 215 ? 161.490 141.780 123.266 1.00 90.20  ? 215 PRO A CD  1 
ATOM   1192 N N   . ASP A 1 216 ? 161.468 142.450 118.733 1.00 95.26  ? 216 ASP A N   1 
ATOM   1193 C CA  . ASP A 1 216 ? 160.570 142.701 117.608 1.00 95.26  ? 216 ASP A CA  1 
ATOM   1194 C C   . ASP A 1 216 ? 159.364 141.780 117.730 1.00 95.26  ? 216 ASP A C   1 
ATOM   1195 O O   . ASP A 1 216 ? 159.418 140.608 117.353 1.00 95.26  ? 216 ASP A O   1 
ATOM   1196 C CB  . ASP A 1 216 ? 161.299 142.486 116.287 1.00 95.26  ? 216 ASP A CB  1 
ATOM   1197 N N   . ASP A 1 217 ? 158.268 142.314 118.257 1.00 92.64  ? 217 ASP A N   1 
ATOM   1198 C CA  . ASP A 1 217 ? 157.055 141.545 118.506 1.00 92.64  ? 217 ASP A CA  1 
ATOM   1199 C C   . ASP A 1 217 ? 155.886 142.521 118.562 1.00 92.64  ? 217 ASP A C   1 
ATOM   1200 O O   . ASP A 1 217 ? 156.000 143.676 118.139 1.00 92.64  ? 217 ASP A O   1 
ATOM   1201 C CB  . ASP A 1 217 ? 157.182 140.721 119.792 1.00 92.64  ? 217 ASP A CB  1 
ATOM   1202 N N   . ASP A 1 218 ? 154.756 142.057 119.093 1.00 88.14  ? 218 ASP A N   1 
ATOM   1203 C CA  . ASP A 1 218 ? 153.571 142.887 119.267 1.00 88.14  ? 218 ASP A CA  1 
ATOM   1204 C C   . ASP A 1 218 ? 153.616 143.731 120.540 1.00 88.14  ? 218 ASP A C   1 
ATOM   1205 O O   . ASP A 1 218 ? 152.561 144.168 121.016 1.00 88.14  ? 218 ASP A O   1 
ATOM   1206 C CB  . ASP A 1 218 ? 152.314 142.015 119.265 1.00 88.14  ? 218 ASP A CB  1 
ATOM   1207 N N   . TYR A 1 219 ? 154.801 143.954 121.106 1.00 83.39  ? 219 TYR A N   1 
ATOM   1208 C CA  . TYR A 1 219 ? 154.967 144.756 122.309 1.00 83.39  ? 219 TYR A CA  1 
ATOM   1209 C C   . TYR A 1 219 ? 155.230 146.223 122.009 1.00 83.39  ? 219 TYR A C   1 
ATOM   1210 O O   . TYR A 1 219 ? 155.494 146.993 122.939 1.00 83.39  ? 219 TYR A O   1 
ATOM   1211 C CB  . TYR A 1 219 ? 156.106 144.192 123.165 1.00 83.39  ? 219 TYR A CB  1 
ATOM   1212 N N   . SER A 1 220 ? 155.182 146.623 120.736 1.00 76.90  ? 220 SER A N   1 
ATOM   1213 C CA  . SER A 1 220 ? 155.371 148.028 120.389 1.00 76.90  ? 220 SER A CA  1 
ATOM   1214 C C   . SER A 1 220 ? 154.237 148.893 120.928 1.00 76.90  ? 220 SER A C   1 
ATOM   1215 O O   . SER A 1 220 ? 154.470 150.018 121.385 1.00 76.90  ? 220 SER A O   1 
ATOM   1216 C CB  . SER A 1 220 ? 155.489 148.176 118.871 1.00 76.90  ? 220 SER A CB  1 
ATOM   1217 N N   . TRP A 1 221 ? 153.002 148.385 120.879 1.00 74.98  ? 221 TRP A N   1 
ATOM   1218 C CA  . TRP A 1 221 ? 151.881 149.113 121.464 1.00 74.98  ? 221 TRP A CA  1 
ATOM   1219 C C   . TRP A 1 221 ? 152.053 149.259 122.971 1.00 74.98  ? 221 TRP A C   1 
ATOM   1220 O O   . TRP A 1 221 ? 151.757 150.318 123.539 1.00 74.98  ? 221 TRP A O   1 
ATOM   1221 C CB  . TRP A 1 221 ? 150.567 148.414 121.133 1.00 74.98  ? 221 TRP A CB  1 
ATOM   1222 N N   . TRP A 1 222 ? 152.557 148.214 123.632 1.00 74.89  ? 222 TRP A N   1 
ATOM   1223 C CA  . TRP A 1 222 ? 152.846 148.305 125.060 1.00 74.89  ? 222 TRP A CA  1 
ATOM   1224 C C   . TRP A 1 222 ? 153.950 149.317 125.345 1.00 74.89  ? 222 TRP A C   1 
ATOM   1225 O O   . TRP A 1 222 ? 153.891 150.037 126.346 1.00 74.89  ? 222 TRP A O   1 
ATOM   1226 C CB  . TRP A 1 222 ? 153.230 146.931 125.609 1.00 74.89  ? 222 TRP A CB  1 
ATOM   1227 N N   . ASP A 1 223 ? 154.975 149.371 124.487 1.00 71.21  ? 223 ASP A N   1 
ATOM   1228 C CA  . ASP A 1 223 ? 156.071 150.318 124.691 1.00 71.21  ? 223 ASP A CA  1 
ATOM   1229 C C   . ASP A 1 223 ? 155.599 151.758 124.528 1.00 71.21  ? 223 ASP A C   1 
ATOM   1230 O O   . ASP A 1 223 ? 155.995 152.639 125.302 1.00 71.21  ? 223 ASP A O   1 
ATOM   1231 C CB  . ASP A 1 223 ? 157.220 150.014 123.728 1.00 71.21  ? 223 ASP A CB  1 
ATOM   1232 C CG  . ASP A 1 223 ? 158.378 150.978 123.882 1.00 71.21  ? 223 ASP A CG  1 
ATOM   1233 O OD1 . ASP A 1 223 ? 158.668 151.372 125.030 1.00 71.21  ? 223 ASP A OD1 1 
ATOM   1234 O OD2 . ASP A 1 223 ? 159.005 151.332 122.862 1.00 71.21  ? 223 ASP A OD2 1 
ATOM   1235 N N   . LEU A 1 224 ? 154.745 152.016 123.533 1.00 71.84  ? 224 LEU A N   1 
ATOM   1236 C CA  . LEU A 1 224 ? 154.163 153.351 123.396 1.00 71.84  ? 224 LEU A CA  1 
ATOM   1237 C C   . LEU A 1 224 ? 153.227 153.687 124.550 1.00 71.84  ? 224 LEU A C   1 
ATOM   1238 O O   . LEU A 1 224 ? 153.176 154.841 124.987 1.00 71.84  ? 224 LEU A O   1 
ATOM   1239 C CB  . LEU A 1 224 ? 153.442 153.516 122.056 1.00 71.84  ? 224 LEU A CB  1 
ATOM   1240 C CG  . LEU A 1 224 ? 154.280 153.953 120.844 1.00 71.84  ? 224 LEU A CG  1 
ATOM   1241 C CD1 . LEU A 1 224 ? 154.849 155.350 121.089 1.00 71.84  ? 224 LEU A CD1 1 
ATOM   1242 C CD2 . LEU A 1 224 ? 155.388 152.999 120.441 1.00 71.84  ? 224 LEU A CD2 1 
ATOM   1243 N N   . PHE A 1 225 ? 152.468 152.707 125.049 1.00 71.39  ? 225 PHE A N   1 
ATOM   1244 C CA  . PHE A 1 225 ? 151.622 152.977 126.208 1.00 71.39  ? 225 PHE A CA  1 
ATOM   1245 C C   . PHE A 1 225 ? 152.460 153.278 127.447 1.00 71.39  ? 225 PHE A C   1 
ATOM   1246 O O   . PHE A 1 225 ? 152.126 154.183 128.218 1.00 71.39  ? 225 PHE A O   1 
ATOM   1247 C CB  . PHE A 1 225 ? 150.663 151.810 126.448 1.00 71.39  ? 225 PHE A CB  1 
ATOM   1248 C CG  . PHE A 1 225 ? 149.326 151.982 125.773 1.00 71.39  ? 225 PHE A CG  1 
ATOM   1249 C CD1 . PHE A 1 225 ? 148.445 152.960 126.205 1.00 71.39  ? 225 PHE A CD1 1 
ATOM   1250 C CD2 . PHE A 1 225 ? 148.956 151.181 124.702 1.00 71.39  ? 225 PHE A CD2 1 
ATOM   1251 C CE1 . PHE A 1 225 ? 147.218 153.133 125.590 1.00 71.39  ? 225 PHE A CE1 1 
ATOM   1252 C CE2 . PHE A 1 225 ? 147.727 151.350 124.079 1.00 71.39  ? 225 PHE A CE2 1 
ATOM   1253 C CZ  . PHE A 1 225 ? 146.858 152.327 124.526 1.00 71.39  ? 225 PHE A CZ  1 
ATOM   1254 N N   . MET A 1 226 ? 153.572 152.559 127.631 1.00 65.44  ? 226 MET A N   1 
ATOM   1255 C CA  . MET A 1 226 ? 154.480 152.844 128.741 1.00 65.44  ? 226 MET A CA  1 
ATOM   1256 C C   . MET A 1 226 ? 155.097 154.229 128.618 1.00 65.44  ? 226 MET A C   1 
ATOM   1257 O O   . MET A 1 226 ? 155.163 154.974 129.605 1.00 65.44  ? 226 MET A O   1 
ATOM   1258 C CB  . MET A 1 226 ? 155.586 151.792 128.809 1.00 65.44  ? 226 MET A CB  1 
ATOM   1259 C CG  . MET A 1 226 ? 156.361 151.783 130.125 1.00 65.44  ? 226 MET A CG  1 
ATOM   1260 S SD  . MET A 1 226 ? 157.836 152.829 130.101 1.00 65.44  ? 226 MET A SD  1 
ATOM   1261 C CE  . MET A 1 226 ? 158.904 151.898 129.012 1.00 65.44  ? 226 MET A CE  1 
ATOM   1262 N N   . LYS A 1 227 ? 155.564 154.586 127.418 1.00 60.52  ? 227 LYS A N   1 
ATOM   1263 C CA  . LYS A 1 227 ? 156.185 155.891 127.216 1.00 60.52  ? 227 LYS A CA  1 
ATOM   1264 C C   . LYS A 1 227 ? 155.178 157.023 127.397 1.00 60.52  ? 227 LYS A C   1 
ATOM   1265 O O   . LYS A 1 227 ? 155.485 158.036 128.039 1.00 60.52  ? 227 LYS A O   1 
ATOM   1266 C CB  . LYS A 1 227 ? 156.833 155.950 125.832 1.00 60.52  ? 227 LYS A CB  1 
ATOM   1267 C CG  . LYS A 1 227 ? 157.309 157.330 125.426 1.00 60.52  ? 227 LYS A CG  1 
ATOM   1268 C CD  . LYS A 1 227 ? 158.373 157.858 126.373 1.00 60.52  ? 227 LYS A CD  1 
ATOM   1269 C CE  . LYS A 1 227 ? 158.444 159.374 126.301 1.00 60.52  ? 227 LYS A CE  1 
ATOM   1270 N NZ  . LYS A 1 227 ? 159.223 159.949 127.428 1.00 60.52  ? 227 LYS A NZ  1 
ATOM   1271 N N   . ILE A 1 228 ? 153.964 156.864 126.864 1.00 57.88  ? 228 ILE A N   1 
ATOM   1272 C CA  . ILE A 1 228 ? 152.959 157.905 127.035 1.00 57.88  ? 228 ILE A CA  1 
ATOM   1273 C C   . ILE A 1 228 ? 152.510 157.987 128.491 1.00 57.88  ? 228 ILE A C   1 
ATOM   1274 O O   . ILE A 1 228 ? 152.246 159.083 128.995 1.00 57.88  ? 228 ILE A O   1 
ATOM   1275 C CB  . ILE A 1 228 ? 151.791 157.700 126.039 1.00 57.88  ? 228 ILE A CB  1 
ATOM   1276 C CG1 . ILE A 1 228 ? 151.123 159.040 125.714 1.00 57.88  ? 228 ILE A CG1 1 
ATOM   1277 C CG2 . ILE A 1 228 ? 150.766 156.670 126.511 1.00 57.88  ? 228 ILE A CG2 1 
ATOM   1278 C CD1 . ILE A 1 228 ? 150.204 158.998 124.508 1.00 57.88  ? 228 ILE A CD1 1 
ATOM   1279 N N   . CYS A 1 229 ? 152.494 156.861 129.217 1.00 54.86  ? 229 CYS A N   1 
ATOM   1280 C CA  . CYS A 1 229 ? 152.088 156.894 130.617 1.00 54.86  ? 229 CYS A CA  1 
ATOM   1281 C C   . CYS A 1 229 ? 153.136 157.581 131.479 1.00 54.86  ? 229 CYS A C   1 
ATOM   1282 O O   . CYS A 1 229 ? 152.793 158.378 132.362 1.00 54.86  ? 229 CYS A O   1 
ATOM   1283 C CB  . CYS A 1 229 ? 151.822 155.476 131.118 1.00 54.86  ? 229 CYS A CB  1 
ATOM   1284 S SG  . CYS A 1 229 ? 151.613 155.342 132.908 1.00 54.86  ? 229 CYS A SG  1 
ATOM   1285 N N   . VAL A 1 230 ? 154.419 157.296 131.235 1.00 51.80  ? 230 VAL A N   1 
ATOM   1286 C CA  . VAL A 1 230 ? 155.452 157.966 132.016 1.00 51.80  ? 230 VAL A CA  1 
ATOM   1287 C C   . VAL A 1 230 ? 155.538 159.440 131.634 1.00 51.80  ? 230 VAL A C   1 
ATOM   1288 O O   . VAL A 1 230 ? 155.814 160.284 132.492 1.00 51.80  ? 230 VAL A O   1 
ATOM   1289 C CB  . VAL A 1 230 ? 156.812 157.241 131.896 1.00 51.80  ? 230 VAL A CB  1 
ATOM   1290 C CG1 . VAL A 1 230 ? 157.418 157.368 130.511 1.00 51.80  ? 230 VAL A CG1 1 
ATOM   1291 C CG2 . VAL A 1 230 ? 157.784 157.745 132.956 1.00 51.80  ? 230 VAL A CG2 1 
ATOM   1292 N N   . PHE A 1 231 ? 155.237 159.793 130.375 1.00 48.64  ? 231 PHE A N   1 
ATOM   1293 C CA  . PHE A 1 231 ? 155.192 161.207 130.005 1.00 48.64  ? 231 PHE A CA  1 
ATOM   1294 C C   . PHE A 1 231 ? 154.062 161.945 130.715 1.00 48.64  ? 231 PHE A C   1 
ATOM   1295 O O   . PHE A 1 231 ? 154.269 163.058 131.214 1.00 48.64  ? 231 PHE A O   1 
ATOM   1296 C CB  . PHE A 1 231 ? 155.039 161.368 128.497 1.00 48.64  ? 231 PHE A CB  1 
ATOM   1297 C CG  . PHE A 1 231 ? 154.904 162.798 128.062 1.00 48.64  ? 231 PHE A CG  1 
ATOM   1298 C CD1 . PHE A 1 231 ? 155.981 163.663 128.136 1.00 48.64  ? 231 PHE A CD1 1 
ATOM   1299 C CD2 . PHE A 1 231 ? 153.693 163.282 127.595 1.00 48.64  ? 231 PHE A CD2 1 
ATOM   1300 C CE1 . PHE A 1 231 ? 155.860 164.980 127.739 1.00 48.64  ? 231 PHE A CE1 1 
ATOM   1301 C CE2 . PHE A 1 231 ? 153.565 164.598 127.196 1.00 48.64  ? 231 PHE A CE2 1 
ATOM   1302 C CZ  . PHE A 1 231 ? 154.650 165.448 127.268 1.00 48.64  ? 231 PHE A CZ  1 
ATOM   1303 N N   . ILE A 1 232 ? 152.862 161.352 130.758 1.00 44.43  ? 232 ILE A N   1 
ATOM   1304 C CA  . ILE A 1 232 ? 151.748 161.986 131.463 1.00 44.43  ? 232 ILE A CA  1 
ATOM   1305 C C   . ILE A 1 232 ? 152.064 162.125 132.946 1.00 44.43  ? 232 ILE A C   1 
ATOM   1306 O O   . ILE A 1 232 ? 152.013 163.227 133.504 1.00 44.43  ? 232 ILE A O   1 
ATOM   1307 C CB  . ILE A 1 232 ? 150.436 161.208 131.241 1.00 44.43  ? 232 ILE A CB  1 
ATOM   1308 C CG1 . ILE A 1 232 ? 150.051 161.182 129.762 1.00 44.43  ? 232 ILE A CG1 1 
ATOM   1309 C CG2 . ILE A 1 232 ? 149.315 161.803 132.073 1.00 44.43  ? 232 ILE A CG2 1 
ATOM   1310 C CD1 . ILE A 1 232 ? 149.817 162.542 129.160 1.00 44.43  ? 232 ILE A CD1 1 
ATOM   1311 N N   . PHE A 1 233 ? 152.476 161.032 133.586 1.00 41.32  ? 233 PHE A N   1 
ATOM   1312 C CA  . PHE A 1 233 ? 152.728 161.067 135.020 1.00 41.32  ? 233 PHE A CA  1 
ATOM   1313 C C   . PHE A 1 233 ? 154.083 161.662 135.376 1.00 41.32  ? 233 PHE A C   1 
ATOM   1314 O O   . PHE A 1 233 ? 154.470 161.614 136.547 1.00 41.32  ? 233 PHE A O   1 
ATOM   1315 C CB  . PHE A 1 233 ? 152.604 159.661 135.612 1.00 41.32  ? 233 PHE A CB  1 
ATOM   1316 C CG  . PHE A 1 233 ? 151.190 159.260 135.940 1.00 41.32  ? 233 PHE A CG  1 
ATOM   1317 C CD1 . PHE A 1 233 ? 150.112 160.025 135.517 1.00 41.32  ? 233 PHE A CD1 1 
ATOM   1318 C CD2 . PHE A 1 233 ? 150.940 158.107 136.671 1.00 41.32  ? 233 PHE A CD2 1 
ATOM   1319 C CE1 . PHE A 1 233 ? 148.814 159.650 135.819 1.00 41.32  ? 233 PHE A CE1 1 
ATOM   1320 C CE2 . PHE A 1 233 ? 149.644 157.726 136.977 1.00 41.32  ? 233 PHE A CE2 1 
ATOM   1321 C CZ  . PHE A 1 233 ? 148.580 158.498 136.550 1.00 41.32  ? 233 PHE A CZ  1 
ATOM   1322 N N   . ALA A 1 234 ? 154.820 162.195 134.405 1.00 39.70  ? 234 ALA A N   1 
ATOM   1323 C CA  . ALA A 1 234 ? 156.011 162.980 134.683 1.00 39.70  ? 234 ALA A CA  1 
ATOM   1324 C C   . ALA A 1 234 ? 155.813 164.467 134.433 1.00 39.70  ? 234 ALA A C   1 
ATOM   1325 O O   . ALA A 1 234 ? 156.156 165.278 135.297 1.00 39.70  ? 234 ALA A O   1 
ATOM   1326 C CB  . ALA A 1 234 ? 157.186 162.462 133.846 1.00 39.70  ? 234 ALA A CB  1 
ATOM   1327 N N   . PHE A 1 235 ? 155.254 164.859 133.281 1.00 38.53  ? 235 PHE A N   1 
ATOM   1328 C CA  . PHE A 1 235 ? 155.152 166.268 132.914 1.00 38.53  ? 235 PHE A CA  1 
ATOM   1329 C C   . PHE A 1 235 ? 153.731 166.700 132.579 1.00 38.53  ? 235 PHE A C   1 
ATOM   1330 O O   . PHE A 1 235 ? 153.537 167.641 131.808 1.00 38.53  ? 235 PHE A O   1 
ATOM   1331 C CB  . PHE A 1 235 ? 156.071 166.590 131.740 1.00 38.53  ? 235 PHE A CB  1 
ATOM   1332 C CG  . PHE A 1 235 ? 157.486 166.816 132.134 1.00 38.53  ? 235 PHE A CG  1 
ATOM   1333 C CD1 . PHE A 1 235 ? 157.812 167.089 133.445 1.00 38.53  ? 235 PHE A CD1 1 
ATOM   1334 C CD2 . PHE A 1 235 ? 158.495 166.742 131.200 1.00 38.53  ? 235 PHE A CD2 1 
ATOM   1335 C CE1 . PHE A 1 235 ? 159.109 167.290 133.819 1.00 38.53  ? 235 PHE A CE1 1 
ATOM   1336 C CE2 . PHE A 1 235 ? 159.798 166.941 131.571 1.00 38.53  ? 235 PHE A CE2 1 
ATOM   1337 C CZ  . PHE A 1 235 ? 160.102 167.216 132.881 1.00 38.53  ? 235 PHE A CZ  1 
ATOM   1338 N N   . VAL A 1 236 ? 152.720 166.038 133.133 1.00 32.82  ? 236 VAL A N   1 
ATOM   1339 C CA  . VAL A 1 236 ? 151.379 166.594 133.031 1.00 32.82  ? 236 VAL A CA  1 
ATOM   1340 C C   . VAL A 1 236 ? 150.839 166.761 134.441 1.00 32.82  ? 236 VAL A C   1 
ATOM   1341 O O   . VAL A 1 236 ? 150.615 167.887 134.900 1.00 32.82  ? 236 VAL A O   1 
ATOM   1342 C CB  . VAL A 1 236 ? 150.458 165.717 132.164 1.00 32.82  ? 236 VAL A CB  1 
ATOM   1343 C CG1 . VAL A 1 236 ? 149.002 166.132 132.331 1.00 32.82  ? 236 VAL A CG1 1 
ATOM   1344 C CG2 . VAL A 1 236 ? 150.865 165.821 130.707 1.00 32.82  ? 236 VAL A CG2 1 
ATOM   1345 N N   . ILE A 1 237 ? 150.665 165.648 135.147 1.00 29.46  ? 237 ILE A N   1 
ATOM   1346 C CA  . ILE A 1 237 ? 150.171 165.674 136.522 1.00 29.46  ? 237 ILE A CA  1 
ATOM   1347 C C   . ILE A 1 237 ? 151.160 166.364 137.465 1.00 29.46  ? 237 ILE A C   1 
ATOM   1348 O O   . ILE A 1 237 ? 150.727 167.269 138.191 1.00 29.46  ? 237 ILE A O   1 
ATOM   1349 C CB  . ILE A 1 237 ? 149.794 164.261 137.003 1.00 29.46  ? 237 ILE A CB  1 
ATOM   1350 C CG1 . ILE A 1 237 ? 148.725 163.664 136.087 1.00 29.46  ? 237 ILE A CG1 1 
ATOM   1351 C CG2 . ILE A 1 237 ? 149.286 164.300 138.428 1.00 29.46  ? 237 ILE A CG2 1 
ATOM   1352 C CD1 . ILE A 1 237 ? 147.445 164.473 136.041 1.00 29.46  ? 237 ILE A CD1 1 
ATOM   1353 N N   . PRO A 1 238 ? 152.466 166.039 137.496 1.00 28.41  ? 238 PRO A N   1 
ATOM   1354 C CA  . PRO A 1 238 ? 153.323 166.722 138.484 1.00 28.41  ? 238 PRO A CA  1 
ATOM   1355 C C   . PRO A 1 238 ? 153.566 168.192 138.194 1.00 28.41  ? 238 PRO A C   1 
ATOM   1356 O O   . PRO A 1 238 ? 153.537 169.003 139.129 1.00 28.41  ? 238 PRO A O   1 
ATOM   1357 C CB  . PRO A 1 238 ? 154.626 165.916 138.433 1.00 28.41  ? 238 PRO A CB  1 
ATOM   1358 C CG  . PRO A 1 238 ? 154.241 164.619 137.877 1.00 28.41  ? 238 PRO A CG  1 
ATOM   1359 C CD  . PRO A 1 238 ? 153.240 164.968 136.841 1.00 28.41  ? 238 PRO A CD  1 
ATOM   1360 N N   . VAL A 1 239 ? 153.803 168.567 136.936 1.00 24.76  ? 239 VAL A N   1 
ATOM   1361 C CA  . VAL A 1 239 ? 154.010 169.979 136.621 1.00 24.76  ? 239 VAL A CA  1 
ATOM   1362 C C   . VAL A 1 239 ? 152.717 170.765 136.811 1.00 24.76  ? 239 VAL A C   1 
ATOM   1363 O O   . VAL A 1 239 ? 152.736 171.902 137.298 1.00 24.76  ? 239 VAL A O   1 
ATOM   1364 C CB  . VAL A 1 239 ? 154.585 170.130 135.201 1.00 24.76  ? 239 VAL A CB  1 
ATOM   1365 C CG1 . VAL A 1 239 ? 154.602 171.583 134.755 1.00 24.76  ? 239 VAL A CG1 1 
ATOM   1366 C CG2 . VAL A 1 239 ? 155.990 169.589 135.170 1.00 24.76  ? 239 VAL A CG2 1 
ATOM   1367 N N   . LEU A 1 240 ? 151.573 170.162 136.469 1.00 22.58  ? 240 LEU A N   1 
ATOM   1368 C CA  . LEU A 1 240 ? 150.289 170.813 136.711 1.00 22.58  ? 240 LEU A CA  1 
ATOM   1369 C C   . LEU A 1 240 ? 150.051 171.034 138.201 1.00 22.58  ? 240 LEU A C   1 
ATOM   1370 O O   . LEU A 1 240 ? 149.608 172.115 138.607 1.00 22.58  ? 240 LEU A O   1 
ATOM   1371 C CB  . LEU A 1 240 ? 149.162 169.990 136.088 1.00 22.58  ? 240 LEU A CB  1 
ATOM   1372 C CG  . LEU A 1 240 ? 147.780 170.630 135.947 1.00 22.58  ? 240 LEU A CG  1 
ATOM   1373 C CD1 . LEU A 1 240 ? 147.163 170.241 134.618 1.00 22.58  ? 240 LEU A CD1 1 
ATOM   1374 C CD2 . LEU A 1 240 ? 146.860 170.210 137.082 1.00 22.58  ? 240 LEU A CD2 1 
ATOM   1375 N N   . ILE A 1 241 ? 150.368 170.036 139.033 1.00 20.58  ? 241 ILE A N   1 
ATOM   1376 C CA  . ILE A 1 241 ? 150.218 170.189 140.478 1.00 20.58  ? 241 ILE A CA  1 
ATOM   1377 C C   . ILE A 1 241 ? 151.163 171.255 141.019 1.00 20.58  ? 241 ILE A C   1 
ATOM   1378 O O   . ILE A 1 241 ? 150.762 172.082 141.843 1.00 20.58  ? 241 ILE A O   1 
ATOM   1379 C CB  . ILE A 1 241 ? 150.407 168.835 141.191 1.00 20.58  ? 241 ILE A CB  1 
ATOM   1380 C CG1 . ILE A 1 241 ? 149.222 167.913 140.915 1.00 20.58  ? 241 ILE A CG1 1 
ATOM   1381 C CG2 . ILE A 1 241 ? 150.590 169.007 142.685 1.00 20.58  ? 241 ILE A CG2 1 
ATOM   1382 C CD1 . ILE A 1 241 ? 149.443 166.501 141.383 1.00 20.58  ? 241 ILE A CD1 1 
ATOM   1383 N N   . ILE A 1 242 ? 152.413 171.276 140.549 1.00 22.21  ? 242 ILE A N   1 
ATOM   1384 C CA  . ILE A 1 242 ? 153.382 172.255 141.045 1.00 22.21  ? 242 ILE A CA  1 
ATOM   1385 C C   . ILE A 1 242 ? 152.953 173.674 140.678 1.00 22.21  ? 242 ILE A C   1 
ATOM   1386 O O   . ILE A 1 242 ? 152.961 174.581 141.523 1.00 22.21  ? 242 ILE A O   1 
ATOM   1387 C CB  . ILE A 1 242 ? 154.790 171.932 140.513 1.00 22.21  ? 242 ILE A CB  1 
ATOM   1388 C CG1 . ILE A 1 242 ? 155.364 170.715 141.239 1.00 22.21  ? 242 ILE A CG1 1 
ATOM   1389 C CG2 . ILE A 1 242 ? 155.724 173.122 140.672 1.00 22.21  ? 242 ILE A CG2 1 
ATOM   1390 C CD1 . ILE A 1 242 ? 156.673 170.226 140.661 1.00 22.21  ? 242 ILE A CD1 1 
ATOM   1391 N N   . ILE A 1 243 ? 152.539 173.878 139.422 1.00 21.16  ? 243 ILE A N   1 
ATOM   1392 C CA  . ILE A 1 243 ? 152.106 175.198 138.965 1.00 21.16  ? 243 ILE A CA  1 
ATOM   1393 C C   . ILE A 1 243 ? 150.849 175.649 139.700 1.00 21.16  ? 243 ILE A C   1 
ATOM   1394 O O   . ILE A 1 243 ? 150.773 176.791 140.173 1.00 21.16  ? 243 ILE A O   1 
ATOM   1395 C CB  . ILE A 1 243 ? 151.898 175.185 137.440 1.00 21.16  ? 243 ILE A CB  1 
ATOM   1396 C CG1 . ILE A 1 243 ? 153.242 175.103 136.726 1.00 21.16  ? 243 ILE A CG1 1 
ATOM   1397 C CG2 . ILE A 1 243 ? 151.129 176.414 136.977 1.00 21.16  ? 243 ILE A CG2 1 
ATOM   1398 C CD1 . ILE A 1 243 ? 154.130 176.278 137.016 1.00 21.16  ? 243 ILE A CD1 1 
ATOM   1399 N N   . VAL A 1 244 ? 149.855 174.762 139.826 1.00 20.87  ? 244 VAL A N   1 
ATOM   1400 C CA  . VAL A 1 244 ? 148.612 175.116 140.503 1.00 20.87  ? 244 VAL A CA  1 
ATOM   1401 C C   . VAL A 1 244 ? 148.869 175.431 141.972 1.00 20.87  ? 244 VAL A C   1 
ATOM   1402 O O   . VAL A 1 244 ? 148.358 176.426 142.504 1.00 20.87  ? 244 VAL A O   1 
ATOM   1403 C CB  . VAL A 1 244 ? 147.578 173.989 140.321 1.00 20.87  ? 244 VAL A CB  1 
ATOM   1404 C CG1 . VAL A 1 244 ? 146.507 174.037 141.398 1.00 20.87  ? 244 VAL A CG1 1 
ATOM   1405 C CG2 . VAL A 1 244 ? 146.946 174.087 138.946 1.00 20.87  ? 244 VAL A CG2 1 
ATOM   1406 N N   . CYS A 1 245 ? 149.699 174.620 142.636 1.00 21.74  ? 245 CYS A N   1 
ATOM   1407 C CA  . CYS A 1 245 ? 149.975 174.826 144.052 1.00 21.74  ? 245 CYS A CA  1 
ATOM   1408 C C   . CYS A 1 245 ? 150.741 176.118 144.294 1.00 21.74  ? 245 CYS A C   1 
ATOM   1409 O O   . CYS A 1 245 ? 150.417 176.864 145.224 1.00 21.74  ? 245 CYS A O   1 
ATOM   1410 C CB  . CYS A 1 245 ? 150.742 173.634 144.618 1.00 21.74  ? 245 CYS A CB  1 
ATOM   1411 S SG  . CYS A 1 245 ? 149.717 172.183 144.927 1.00 21.74  ? 245 CYS A SG  1 
ATOM   1412 N N   . TYR A 1 246 ? 151.737 176.424 143.458 1.00 23.31  ? 246 TYR A N   1 
ATOM   1413 C CA  . TYR A 1 246 ? 152.479 177.665 143.663 1.00 23.31  ? 246 TYR A CA  1 
ATOM   1414 C C   . TYR A 1 246 ? 151.636 178.892 143.332 1.00 23.31  ? 246 TYR A C   1 
ATOM   1415 O O   . TYR A 1 246 ? 151.733 179.917 144.022 1.00 23.31  ? 246 TYR A O   1 
ATOM   1416 C CB  . TYR A 1 246 ? 153.769 177.669 142.850 1.00 23.31  ? 246 TYR A CB  1 
ATOM   1417 C CG  . TYR A 1 246 ? 154.900 176.898 143.488 1.00 23.31  ? 246 TYR A CG  1 
ATOM   1418 C CD1 . TYR A 1 246 ? 154.836 176.496 144.816 1.00 23.31  ? 246 TYR A CD1 1 
ATOM   1419 C CD2 . TYR A 1 246 ? 156.055 176.611 142.773 1.00 23.31  ? 246 TYR A CD2 1 
ATOM   1420 C CE1 . TYR A 1 246 ? 155.879 175.802 145.402 1.00 23.31  ? 246 TYR A CE1 1 
ATOM   1421 C CE2 . TYR A 1 246 ? 157.103 175.922 143.351 1.00 23.31  ? 246 TYR A CE2 1 
ATOM   1422 C CZ  . TYR A 1 246 ? 157.010 175.519 144.664 1.00 23.31  ? 246 TYR A CZ  1 
ATOM   1423 O OH  . TYR A 1 246 ? 158.056 174.832 145.236 1.00 23.31  ? 246 TYR A OH  1 
ATOM   1424 N N   . THR A 1 247 ? 150.797 178.817 142.291 1.00 21.76  ? 247 THR A N   1 
ATOM   1425 C CA  . THR A 1 247 ? 149.943 179.956 141.968 1.00 21.76  ? 247 THR A CA  1 
ATOM   1426 C C   . THR A 1 247 ? 148.903 180.196 143.055 1.00 21.76  ? 247 THR A C   1 
ATOM   1427 O O   . THR A 1 247 ? 148.643 181.346 143.424 1.00 21.76  ? 247 THR A O   1 
ATOM   1428 C CB  . THR A 1 247 ? 149.263 179.756 140.615 1.00 21.76  ? 247 THR A CB  1 
ATOM   1429 O OG1 . THR A 1 247 ? 148.795 178.407 140.507 1.00 21.76  ? 247 THR A OG1 1 
ATOM   1430 C CG2 . THR A 1 247 ? 150.234 180.049 139.485 1.00 21.76  ? 247 THR A CG2 1 
ATOM   1431 N N   . LEU A 1 248 ? 148.315 179.127 143.598 1.00 20.16  ? 248 LEU A N   1 
ATOM   1432 C CA  . LEU A 1 248 ? 147.362 179.296 144.688 1.00 20.16  ? 248 LEU A CA  1 
ATOM   1433 C C   . LEU A 1 248 ? 148.062 179.752 145.962 1.00 20.16  ? 248 LEU A C   1 
ATOM   1434 O O   . LEU A 1 248 ? 147.473 180.472 146.774 1.00 20.16  ? 248 LEU A O   1 
ATOM   1435 C CB  . LEU A 1 248 ? 146.599 177.997 144.921 1.00 20.16  ? 248 LEU A CB  1 
ATOM   1436 C CG  . LEU A 1 248 ? 145.533 177.708 143.866 1.00 20.16  ? 248 LEU A CG  1 
ATOM   1437 C CD1 . LEU A 1 248 ? 144.982 176.302 144.028 1.00 20.16  ? 248 LEU A CD1 1 
ATOM   1438 C CD2 . LEU A 1 248 ? 144.424 178.738 143.933 1.00 20.16  ? 248 LEU A CD2 1 
ATOM   1439 N N   . MET A 1 249 ? 149.325 179.358 146.144 1.00 21.91  ? 249 MET A N   1 
ATOM   1440 C CA  . MET A 1 249 ? 150.101 179.834 147.282 1.00 21.91  ? 249 MET A CA  1 
ATOM   1441 C C   . MET A 1 249 ? 150.343 181.336 147.201 1.00 21.91  ? 249 MET A C   1 
ATOM   1442 O O   . MET A 1 249 ? 150.176 182.052 148.195 1.00 21.91  ? 249 MET A O   1 
ATOM   1443 C CB  . MET A 1 249 ? 151.426 179.078 147.346 1.00 21.91  ? 249 MET A CB  1 
ATOM   1444 C CG  . MET A 1 249 ? 152.306 179.474 148.501 1.00 21.91  ? 249 MET A CG  1 
ATOM   1445 S SD  . MET A 1 249 ? 153.858 178.566 148.566 1.00 21.91  ? 249 MET A SD  1 
ATOM   1446 C CE  . MET A 1 249 ? 154.743 179.323 147.211 1.00 21.91  ? 249 MET A CE  1 
ATOM   1447 N N   . ILE A 1 250 ? 150.719 181.833 146.021 1.00 23.83  ? 250 ILE A N   1 
ATOM   1448 C CA  . ILE A 1 250 ? 150.929 183.271 145.863 1.00 23.83  ? 250 ILE A CA  1 
ATOM   1449 C C   . ILE A 1 250 ? 149.603 184.024 145.956 1.00 23.83  ? 250 ILE A C   1 
ATOM   1450 O O   . ILE A 1 250 ? 149.536 185.123 146.523 1.00 23.83  ? 250 ILE A O   1 
ATOM   1451 C CB  . ILE A 1 250 ? 151.672 183.555 144.547 1.00 23.83  ? 250 ILE A CB  1 
ATOM   1452 C CG1 . ILE A 1 250 ? 153.045 182.897 144.583 1.00 23.83  ? 250 ILE A CG1 1 
ATOM   1453 C CG2 . ILE A 1 250 ? 151.869 185.043 144.339 1.00 23.83  ? 250 ILE A CG2 1 
ATOM   1454 C CD1 . ILE A 1 250 ? 153.872 183.300 145.775 1.00 23.83  ? 250 ILE A CD1 1 
ATOM   1455 N N   . LEU A 1 251 ? 148.523 183.437 145.426 1.00 24.00  ? 251 LEU A N   1 
ATOM   1456 C CA  . LEU A 1 251 ? 147.197 184.037 145.556 1.00 24.00  ? 251 LEU A CA  1 
ATOM   1457 C C   . LEU A 1 251 ? 146.755 184.131 147.013 1.00 24.00  ? 251 LEU A C   1 
ATOM   1458 O O   . LEU A 1 251 ? 146.104 185.109 147.397 1.00 24.00  ? 251 LEU A O   1 
ATOM   1459 C CB  . LEU A 1 251 ? 146.179 183.235 144.740 1.00 24.00  ? 251 LEU A CB  1 
ATOM   1460 C CG  . LEU A 1 251 ? 144.796 183.831 144.447 1.00 24.00  ? 251 LEU A CG  1 
ATOM   1461 C CD1 . LEU A 1 251 ? 144.355 183.471 143.037 1.00 24.00  ? 251 LEU A CD1 1 
ATOM   1462 C CD2 . LEU A 1 251 ? 143.750 183.353 145.451 1.00 24.00  ? 251 LEU A CD2 1 
ATOM   1463 N N   . ARG A 1 252 ? 147.080 183.129 147.830 1.00 23.67  ? 252 ARG A N   1 
ATOM   1464 C CA  . ARG A 1 252 ? 146.772 183.218 149.253 1.00 23.67  ? 252 ARG A CA  1 
ATOM   1465 C C   . ARG A 1 252 ? 147.684 184.221 149.947 1.00 23.67  ? 252 ARG A C   1 
ATOM   1466 O O   . ARG A 1 252 ? 147.258 184.917 150.875 1.00 23.67  ? 252 ARG A O   1 
ATOM   1467 C CB  . ARG A 1 252 ? 146.873 181.836 149.896 1.00 23.67  ? 252 ARG A CB  1 
ATOM   1468 C CG  . ARG A 1 252 ? 146.618 181.824 151.391 1.00 23.67  ? 252 ARG A CG  1 
ATOM   1469 C CD  . ARG A 1 252 ? 145.204 182.276 151.716 1.00 23.67  ? 252 ARG A CD  1 
ATOM   1470 N NE  . ARG A 1 252 ? 144.839 181.958 153.090 1.00 23.67  ? 252 ARG A NE  1 
ATOM   1471 C CZ  . ARG A 1 252 ? 145.146 182.709 154.138 1.00 23.67  ? 252 ARG A CZ  1 
ATOM   1472 N NH1 . ARG A 1 252 ? 145.848 183.823 154.009 1.00 23.67  ? 252 ARG A NH1 1 
ATOM   1473 N NH2 . ARG A 1 252 ? 144.743 182.331 155.348 1.00 23.67  ? 252 ARG A NH2 1 
ATOM   1474 N N   . LEU A 1 253 ? 148.933 184.333 149.493 1.00 24.58  ? 253 LEU A N   1 
ATOM   1475 C CA  . LEU A 1 253 ? 149.830 185.343 150.040 1.00 24.58  ? 253 LEU A CA  1 
ATOM   1476 C C   . LEU A 1 253 ? 149.448 186.760 149.620 1.00 24.58  ? 253 LEU A C   1 
ATOM   1477 O O   . LEU A 1 253 ? 149.967 187.719 150.200 1.00 24.58  ? 253 LEU A O   1 
ATOM   1478 C CB  . LEU A 1 253 ? 151.273 185.056 149.628 1.00 24.58  ? 253 LEU A CB  1 
ATOM   1479 C CG  . LEU A 1 253 ? 151.968 183.872 150.296 1.00 24.58  ? 253 LEU A CG  1 
ATOM   1480 C CD1 . LEU A 1 253 ? 153.464 183.939 150.068 1.00 24.58  ? 253 LEU A CD1 1 
ATOM   1481 C CD2 . LEU A 1 253 ? 151.661 183.839 151.777 1.00 24.58  ? 253 LEU A CD2 1 
ATOM   1482 N N   . LYS A 1 254 ? 148.576 186.917 148.620 1.00 30.69  ? 254 LYS A N   1 
ATOM   1483 C CA  . LYS A 1 254 ? 148.031 188.240 148.318 1.00 30.69  ? 254 LYS A CA  1 
ATOM   1484 C C   . LYS A 1 254 ? 147.237 188.797 149.493 1.00 30.69  ? 254 LYS A C   1 
ATOM   1485 O O   . LYS A 1 254 ? 147.382 189.971 149.852 1.00 30.69  ? 254 LYS A O   1 
ATOM   1486 C CB  . LYS A 1 254 ? 147.135 188.178 147.077 1.00 30.69  ? 254 LYS A CB  1 
ATOM   1487 C CG  . LYS A 1 254 ? 147.775 187.747 145.752 1.00 30.69  ? 254 LYS A CG  1 
ATOM   1488 C CD  . LYS A 1 254 ? 148.699 188.807 145.133 1.00 30.69  ? 254 LYS A CD  1 
ATOM   1489 C CE  . LYS A 1 254 ? 150.171 188.629 145.478 1.00 30.69  ? 254 LYS A CE  1 
ATOM   1490 N NZ  . LYS A 1 254 ? 151.014 189.621 144.760 1.00 30.69  ? 254 LYS A NZ  1 
ATOM   1491 N N   . SER A 1 255 ? 146.409 187.963 150.114 1.00 33.57  ? 255 SER A N   1 
ATOM   1492 C CA  . SER A 1 255 ? 145.413 188.421 151.071 1.00 33.57  ? 255 SER A CA  1 
ATOM   1493 C C   . SER A 1 255 ? 145.949 188.586 152.487 1.00 33.57  ? 255 SER A C   1 
ATOM   1494 O O   . SER A 1 255 ? 145.231 189.122 153.338 1.00 33.57  ? 255 SER A O   1 
ATOM   1495 C CB  . SER A 1 255 ? 144.225 187.451 151.085 1.00 33.57  ? 255 SER A CB  1 
ATOM   1496 O OG  . SER A 1 255 ? 143.225 187.871 151.997 1.00 33.57  ? 255 SER A OG  1 
ATOM   1497 N N   . VAL A 1 256 ? 147.178 188.152 152.767 1.00 33.73  ? 256 VAL A N   1 
ATOM   1498 C CA  . VAL A 1 256 ? 147.700 188.252 154.124 1.00 33.73  ? 256 VAL A CA  1 
ATOM   1499 C C   . VAL A 1 256 ? 148.051 189.702 154.436 1.00 33.73  ? 256 VAL A C   1 
ATOM   1500 O O   . VAL A 1 256 ? 148.117 190.562 153.555 1.00 33.73  ? 256 VAL A O   1 
ATOM   1501 C CB  . VAL A 1 256 ? 148.912 187.329 154.331 1.00 33.73  ? 256 VAL A CB  1 
ATOM   1502 C CG1 . VAL A 1 256 ? 148.534 185.884 154.065 1.00 33.73  ? 256 VAL A CG1 1 
ATOM   1503 C CG2 . VAL A 1 256 ? 150.058 187.758 153.459 1.00 33.73  ? 256 VAL A CG2 1 
ATOM   1504 N N   . ARG A 1 257 ? 148.272 189.977 155.721 1.00 36.86  ? 257 ARG A N   1 
ATOM   1505 C CA  . ARG A 1 257 ? 148.541 191.335 156.173 1.00 36.86  ? 257 ARG A CA  1 
ATOM   1506 C C   . ARG A 1 257 ? 149.993 191.555 156.589 1.00 36.86  ? 257 ARG A C   1 
ATOM   1507 O O   . ARG A 1 257 ? 150.426 192.710 156.672 1.00 36.86  ? 257 ARG A O   1 
ATOM   1508 C CB  . ARG A 1 257 ? 147.587 191.688 157.326 1.00 36.86  ? 257 ARG A CB  1 
ATOM   1509 C CG  . ARG A 1 257 ? 147.276 193.176 157.510 1.00 36.86  ? 257 ARG A CG  1 
ATOM   1510 C CD  . ARG A 1 257 ? 146.058 193.353 158.418 1.00 36.86  ? 257 ARG A CD  1 
ATOM   1511 N NE  . ARG A 1 257 ? 145.965 194.676 159.025 1.00 36.86  ? 257 ARG A NE  1 
ATOM   1512 C CZ  . ARG A 1 257 ? 144.946 195.086 159.771 1.00 36.86  ? 257 ARG A CZ  1 
ATOM   1513 N NH1 . ARG A 1 257 ? 143.907 194.305 160.011 1.00 36.86  ? 257 ARG A NH1 1 
ATOM   1514 N NH2 . ARG A 1 257 ? 144.972 196.310 160.291 1.00 36.86  ? 257 ARG A NH2 1 
ATOM   1515 N N   . LEU A 1 258 ? 150.758 190.489 156.829 1.00 44.08  ? 258 LEU A N   1 
ATOM   1516 C CA  . LEU A 1 258 ? 152.183 190.600 157.124 1.00 44.08  ? 258 LEU A CA  1 
ATOM   1517 C C   . LEU A 1 258 ? 153.078 190.482 155.900 1.00 44.08  ? 258 LEU A C   1 
ATOM   1518 O O   . LEU A 1 258 ? 154.301 190.564 156.043 1.00 44.08  ? 258 LEU A O   1 
ATOM   1519 C CB  . LEU A 1 258 ? 152.619 189.544 158.144 1.00 44.08  ? 258 LEU A CB  1 
ATOM   1520 C CG  . LEU A 1 258 ? 152.572 189.898 159.628 1.00 44.08  ? 258 LEU A CG  1 
ATOM   1521 C CD1 . LEU A 1 258 ? 151.175 189.937 160.152 1.00 44.08  ? 258 LEU A CD1 1 
ATOM   1522 C CD2 . LEU A 1 258 ? 153.388 188.902 160.415 1.00 44.08  ? 258 LEU A CD2 1 
ATOM   1523 N N   . LEU A 1 259 ? 152.519 190.271 154.708 1.00 46.02  ? 259 LEU A N   1 
ATOM   1524 C CA  . LEU A 1 259 ? 153.356 190.192 153.518 1.00 46.02  ? 259 LEU A CA  1 
ATOM   1525 C C   . LEU A 1 259 ? 152.802 191.020 152.365 1.00 46.02  ? 259 LEU A C   1 
ATOM   1526 O O   . LEU A 1 259 ? 153.303 190.898 151.241 1.00 46.02  ? 259 LEU A O   1 
ATOM   1527 C CB  . LEU A 1 259 ? 153.544 188.739 153.062 1.00 46.02  ? 259 LEU A CB  1 
ATOM   1528 C CG  . LEU A 1 259 ? 154.417 187.804 153.902 1.00 46.02  ? 259 LEU A CG  1 
ATOM   1529 C CD1 . LEU A 1 259 ? 153.604 187.107 154.982 1.00 46.02  ? 259 LEU A CD1 1 
ATOM   1530 C CD2 . LEU A 1 259 ? 155.109 186.785 153.014 1.00 46.02  ? 259 LEU A CD2 1 
ATOM   1531 N N   . SER A 1 260 ? 151.796 191.856 152.603 1.00 51.06  ? 260 SER A N   1 
ATOM   1532 C CA  . SER A 1 260 ? 151.180 192.679 151.568 1.00 51.06  ? 260 SER A CA  1 
ATOM   1533 C C   . SER A 1 260 ? 151.180 194.143 151.985 1.00 51.06  ? 260 SER A C   1 
ATOM   1534 O O   . SER A 1 260 ? 150.167 194.841 151.910 1.00 51.06  ? 260 SER A O   1 
ATOM   1535 C CB  . SER A 1 260 ? 149.765 192.204 151.265 1.00 51.06  ? 260 SER A CB  1 
ATOM   1536 O OG  . SER A 1 260 ? 148.901 192.471 152.353 1.00 51.06  ? 260 SER A OG  1 
ATOM   1537 N N   . GLY A 1 261 ? 152.327 194.622 152.445 1.00 59.08  ? 261 GLY A N   1 
ATOM   1538 C CA  . GLY A 1 261 ? 152.514 196.018 152.788 1.00 59.08  ? 261 GLY A CA  1 
ATOM   1539 C C   . GLY A 1 261 ? 153.131 196.811 151.659 1.00 59.08  ? 261 GLY A C   1 
ATOM   1540 O O   . GLY A 1 261 ? 152.872 196.563 150.477 1.00 59.08  ? 261 GLY A O   1 
ATOM   1541 N N   . SER A 1 262 ? 153.962 197.786 152.025 1.00 62.26  ? 262 SER A N   1 
ATOM   1542 C CA  . SER A 1 262 ? 154.600 198.652 151.043 1.00 62.26  ? 262 SER A CA  1 
ATOM   1543 C C   . SER A 1 262 ? 156.092 198.871 151.256 1.00 62.26  ? 262 SER A C   1 
ATOM   1544 O O   . SER A 1 262 ? 156.756 199.342 150.324 1.00 62.26  ? 262 SER A O   1 
ATOM   1545 C CB  . SER A 1 262 ? 153.907 200.023 151.007 1.00 62.26  ? 262 SER A CB  1 
ATOM   1546 O OG  . SER A 1 262 ? 153.614 200.482 152.315 1.00 62.26  ? 262 SER A OG  1 
ATOM   1547 N N   . ARG A 1 263 ? 156.644 198.562 152.429 1.00 65.38  ? 263 ARG A N   1 
ATOM   1548 C CA  . ARG A 1 263 ? 158.035 198.907 152.711 1.00 65.38  ? 263 ARG A CA  1 
ATOM   1549 C C   . ARG A 1 263 ? 158.996 197.766 152.382 1.00 65.38  ? 263 ARG A C   1 
ATOM   1550 O O   . ARG A 1 263 ? 159.855 197.904 151.506 1.00 65.38  ? 263 ARG A O   1 
ATOM   1551 C CB  . ARG A 1 263 ? 158.180 199.321 154.180 1.00 65.38  ? 263 ARG A CB  1 
ATOM   1552 N N   . GLU A 1 264 ? 158.863 196.635 153.076 1.00 66.55  ? 264 GLU A N   1 
ATOM   1553 C CA  . GLU A 1 264 ? 159.740 195.489 152.840 1.00 66.55  ? 264 GLU A CA  1 
ATOM   1554 C C   . GLU A 1 264 ? 159.014 194.160 152.721 1.00 66.55  ? 264 GLU A C   1 
ATOM   1555 O O   . GLU A 1 264 ? 159.569 193.233 152.124 1.00 66.55  ? 264 GLU A O   1 
ATOM   1556 C CB  . GLU A 1 264 ? 160.793 195.373 153.950 1.00 66.55  ? 264 GLU A CB  1 
ATOM   1557 C CG  . GLU A 1 264 ? 161.832 196.482 153.950 1.00 66.55  ? 264 GLU A CG  1 
ATOM   1558 C CD  . GLU A 1 264 ? 162.870 196.309 155.041 1.00 66.55  ? 264 GLU A CD  1 
ATOM   1559 O OE1 . GLU A 1 264 ? 162.700 195.408 155.889 1.00 66.55  ? 264 GLU A OE1 1 
ATOM   1560 O OE2 . GLU A 1 264 ? 163.858 197.074 155.050 1.00 66.55  ? 264 GLU A OE2 1 
ATOM   1561 N N   . LYS A 1 265 ? 157.802 194.014 153.251 1.00 59.98  ? 265 LYS A N   1 
ATOM   1562 C CA  . LYS A 1 265 ? 157.095 192.751 153.105 1.00 59.98  ? 265 LYS A CA  1 
ATOM   1563 C C   . LYS A 1 265 ? 156.552 192.545 151.694 1.00 59.98  ? 265 LYS A C   1 
ATOM   1564 O O   . LYS A 1 265 ? 156.431 191.394 151.252 1.00 59.98  ? 265 LYS A O   1 
ATOM   1565 C CB  . LYS A 1 265 ? 156.003 192.666 154.170 1.00 59.98  ? 265 LYS A CB  1 
ATOM   1566 C CG  . LYS A 1 265 ? 155.244 193.957 154.407 1.00 59.98  ? 265 LYS A CG  1 
ATOM   1567 C CD  . LYS A 1 265 ? 154.461 193.865 155.711 1.00 59.98  ? 265 LYS A CD  1 
ATOM   1568 C CE  . LYS A 1 265 ? 153.829 195.190 156.094 1.00 59.98  ? 265 LYS A CE  1 
ATOM   1569 N NZ  . LYS A 1 265 ? 154.859 196.206 156.450 1.00 59.98  ? 265 LYS A NZ  1 
ATOM   1570 N N   . ASP A 1 266 ? 156.284 193.626 150.956 1.00 60.96  ? 266 ASP A N   1 
ATOM   1571 C CA  . ASP A 1 266 ? 155.932 193.481 149.547 1.00 60.96  ? 266 ASP A CA  1 
ATOM   1572 C C   . ASP A 1 266 ? 157.099 192.929 148.731 1.00 60.96  ? 266 ASP A C   1 
ATOM   1573 O O   . ASP A 1 266 ? 156.913 192.025 147.908 1.00 60.96  ? 266 ASP A O   1 
ATOM   1574 C CB  . ASP A 1 266 ? 155.448 194.816 148.980 1.00 60.96  ? 266 ASP A CB  1 
ATOM   1575 C CG  . ASP A 1 266 ? 156.431 195.946 149.215 1.00 60.96  ? 266 ASP A CG  1 
ATOM   1576 O OD1 . ASP A 1 266 ? 157.393 195.754 149.988 1.00 60.96  ? 266 ASP A OD1 1 
ATOM   1577 O OD2 . ASP A 1 266 ? 156.244 197.025 148.617 1.00 60.96  ? 266 ASP A OD2 1 
ATOM   1578 N N   . ARG A 1 267 ? 158.317 193.429 148.958 1.00 61.30  ? 267 ARG A N   1 
ATOM   1579 C CA  . ARG A 1 267 ? 159.459 192.865 148.248 1.00 61.30  ? 267 ARG A CA  1 
ATOM   1580 C C   . ARG A 1 267 ? 159.870 191.507 148.802 1.00 61.30  ? 267 ARG A C   1 
ATOM   1581 O O   . ARG A 1 267 ? 160.496 190.725 148.080 1.00 61.30  ? 267 ARG A O   1 
ATOM   1582 C CB  . ARG A 1 267 ? 160.648 193.833 148.265 1.00 61.30  ? 267 ARG A CB  1 
ATOM   1583 C CG  . ARG A 1 267 ? 161.329 194.012 149.605 1.00 61.30  ? 267 ARG A CG  1 
ATOM   1584 C CD  . ARG A 1 267 ? 162.534 194.933 149.500 1.00 61.30  ? 267 ARG A CD  1 
ATOM   1585 N NE  . ARG A 1 267 ? 163.121 195.214 150.806 1.00 61.30  ? 267 ARG A NE  1 
ATOM   1586 C CZ  . ARG A 1 267 ? 164.036 194.458 151.397 1.00 61.30  ? 267 ARG A CZ  1 
ATOM   1587 N NH1 . ARG A 1 267 ? 164.507 193.365 150.820 1.00 61.30  ? 267 ARG A NH1 1 
ATOM   1588 N NH2 . ARG A 1 267 ? 164.492 194.809 152.596 1.00 61.30  ? 267 ARG A NH2 1 
ATOM   1589 N N   . ASN A 1 268 ? 159.510 191.197 150.051 1.00 58.37  ? 268 ASN A N   1 
ATOM   1590 C CA  . ASN A 1 268 ? 159.660 189.832 150.546 1.00 58.37  ? 268 ASN A CA  1 
ATOM   1591 C C   . ASN A 1 268 ? 158.772 188.869 149.767 1.00 58.37  ? 268 ASN A C   1 
ATOM   1592 O O   . ASN A 1 268 ? 159.212 187.781 149.372 1.00 58.37  ? 268 ASN A O   1 
ATOM   1593 C CB  . ASN A 1 268 ? 159.329 189.777 152.036 1.00 58.37  ? 268 ASN A CB  1 
ATOM   1594 C CG  . ASN A 1 268 ? 160.517 190.116 152.911 1.00 58.37  ? 268 ASN A CG  1 
ATOM   1595 O OD1 . ASN A 1 268 ? 161.602 189.561 152.744 1.00 58.37  ? 268 ASN A OD1 1 
ATOM   1596 N ND2 . ASN A 1 268 ? 160.318 191.032 153.851 1.00 58.37  ? 268 ASN A ND2 1 
ATOM   1597 N N   . LEU A 1 269 ? 157.518 189.259 149.526 1.00 51.86  ? 269 LEU A N   1 
ATOM   1598 C CA  . LEU A 1 269 ? 156.644 188.442 148.689 1.00 51.86  ? 269 LEU A CA  1 
ATOM   1599 C C   . LEU A 1 269 ? 157.162 188.377 147.256 1.00 51.86  ? 269 LEU A C   1 
ATOM   1600 O O   . LEU A 1 269 ? 157.046 187.338 146.593 1.00 51.86  ? 269 LEU A O   1 
ATOM   1601 C CB  . LEU A 1 269 ? 155.214 188.986 148.740 1.00 51.86  ? 269 LEU A CB  1 
ATOM   1602 C CG  . LEU A 1 269 ? 154.061 188.191 148.118 1.00 51.86  ? 269 LEU A CG  1 
ATOM   1603 C CD1 . LEU A 1 269 ? 152.810 188.481 148.899 1.00 51.86  ? 269 LEU A CD1 1 
ATOM   1604 C CD2 . LEU A 1 269 ? 153.818 188.559 146.661 1.00 51.86  ? 269 LEU A CD2 1 
ATOM   1605 N N   . ARG A 1 270 ? 157.740 189.479 146.768 1.00 54.36  ? 270 ARG A N   1 
ATOM   1606 C CA  . ARG A 1 270 ? 158.316 189.495 145.425 1.00 54.36  ? 270 ARG A CA  1 
ATOM   1607 C C   . ARG A 1 270 ? 159.476 188.512 145.296 1.00 54.36  ? 270 ARG A C   1 
ATOM   1608 O O   . ARG A 1 270 ? 159.560 187.772 144.311 1.00 54.36  ? 270 ARG A O   1 
ATOM   1609 C CB  . ARG A 1 270 ? 158.775 190.909 145.069 1.00 54.36  ? 270 ARG A CB  1 
ATOM   1610 C CG  . ARG A 1 270 ? 159.234 191.080 143.629 1.00 54.36  ? 270 ARG A CG  1 
ATOM   1611 C CD  . ARG A 1 270 ? 158.051 191.084 142.676 1.00 54.36  ? 270 ARG A CD  1 
ATOM   1612 N NE  . ARG A 1 270 ? 158.437 191.408 141.307 1.00 54.36  ? 270 ARG A NE  1 
ATOM   1613 C CZ  . ARG A 1 270 ? 158.770 190.514 140.386 1.00 54.36  ? 270 ARG A CZ  1 
ATOM   1614 N NH1 . ARG A 1 270 ? 158.790 189.219 140.654 1.00 54.36  ? 270 ARG A NH1 1 
ATOM   1615 N NH2 . ARG A 1 270 ? 159.089 190.931 139.164 1.00 54.36  ? 270 ARG A NH2 1 
ATOM   1616 N N   . ARG A 1 271 ? 160.371 188.477 146.286 1.00 58.55  ? 271 ARG A N   1 
ATOM   1617 C CA  . ARG A 1 271 ? 161.498 187.552 146.205 1.00 58.55  ? 271 ARG A CA  1 
ATOM   1618 C C   . ARG A 1 271 ? 161.066 186.110 146.448 1.00 58.55  ? 271 ARG A C   1 
ATOM   1619 O O   . ARG A 1 271 ? 161.673 185.192 145.891 1.00 58.55  ? 271 ARG A O   1 
ATOM   1620 C CB  . ARG A 1 271 ? 162.616 187.968 147.169 1.00 58.55  ? 271 ARG A CB  1 
ATOM   1621 C CG  . ARG A 1 271 ? 162.290 187.870 148.646 1.00 58.55  ? 271 ARG A CG  1 
ATOM   1622 C CD  . ARG A 1 271 ? 163.492 188.190 149.523 1.00 58.55  ? 271 ARG A CD  1 
ATOM   1623 N NE  . ARG A 1 271 ? 164.503 187.141 149.476 1.00 58.55  ? 271 ARG A NE  1 
ATOM   1624 C CZ  . ARG A 1 271 ? 164.475 186.041 150.217 1.00 58.55  ? 271 ARG A CZ  1 
ATOM   1625 N NH1 . ARG A 1 271 ? 163.501 185.816 151.084 1.00 58.55  ? 271 ARG A NH1 1 
ATOM   1626 N NH2 . ARG A 1 271 ? 165.449 185.146 150.087 1.00 58.55  ? 271 ARG A NH2 1 
ATOM   1627 N N   . ILE A 1 272 ? 160.007 185.885 147.232 1.00 53.29  ? 272 ILE A N   1 
ATOM   1628 C CA  . ILE A 1 272 ? 159.475 184.529 147.388 1.00 53.29  ? 272 ILE A CA  1 
ATOM   1629 C C   . ILE A 1 272 ? 158.876 184.032 146.071 1.00 53.29  ? 272 ILE A C   1 
ATOM   1630 O O   . ILE A 1 272 ? 159.091 182.879 145.657 1.00 53.29  ? 272 ILE A O   1 
ATOM   1631 C CB  . ILE A 1 272 ? 158.452 184.489 148.539 1.00 53.29  ? 272 ILE A CB  1 
ATOM   1632 C CG1 . ILE A 1 272 ? 159.174 184.553 149.886 1.00 53.29  ? 272 ILE A CG1 1 
ATOM   1633 C CG2 . ILE A 1 272 ? 157.581 183.245 148.467 1.00 53.29  ? 272 ILE A CG2 1 
ATOM   1634 C CD1 . ILE A 1 272 ? 158.291 184.987 151.035 1.00 53.29  ? 272 ILE A CD1 1 
ATOM   1635 N N   . THR A 1 273 ? 158.123 184.900 145.388 1.00 49.92  ? 273 THR A N   1 
ATOM   1636 C CA  . THR A 1 273 ? 157.564 184.536 144.089 1.00 49.92  ? 273 THR A CA  1 
ATOM   1637 C C   . THR A 1 273 ? 158.661 184.330 143.049 1.00 49.92  ? 273 THR A C   1 
ATOM   1638 O O   . THR A 1 273 ? 158.570 183.421 142.215 1.00 49.92  ? 273 THR A O   1 
ATOM   1639 C CB  . THR A 1 273 ? 156.574 185.601 143.623 1.00 49.92  ? 273 THR A CB  1 
ATOM   1640 O OG1 . THR A 1 273 ? 155.711 185.957 144.710 1.00 49.92  ? 273 THR A OG1 1 
ATOM   1641 C CG2 . THR A 1 273 ? 155.728 185.072 142.476 1.00 49.92  ? 273 THR A CG2 1 
ATOM   1642 N N   . ARG A 1 274 ? 159.713 185.153 143.092 1.00 53.13  ? 274 ARG A N   1 
ATOM   1643 C CA  . ARG A 1 274 ? 160.856 184.942 142.209 1.00 53.13  ? 274 ARG A CA  1 
ATOM   1644 C C   . ARG A 1 274 ? 161.551 183.622 142.510 1.00 53.13  ? 274 ARG A C   1 
ATOM   1645 O O   . ARG A 1 274 ? 162.032 182.947 141.595 1.00 53.13  ? 274 ARG A O   1 
ATOM   1646 C CB  . ARG A 1 274 ? 161.847 186.097 142.330 1.00 53.13  ? 274 ARG A CB  1 
ATOM   1647 C CG  . ARG A 1 274 ? 161.493 187.314 141.498 1.00 53.13  ? 274 ARG A CG  1 
ATOM   1648 C CD  . ARG A 1 274 ? 162.598 188.355 141.558 1.00 53.13  ? 274 ARG A CD  1 
ATOM   1649 N NE  . ARG A 1 274 ? 163.815 187.898 140.897 1.00 53.13  ? 274 ARG A NE  1 
ATOM   1650 C CZ  . ARG A 1 274 ? 164.928 187.549 141.528 1.00 53.13  ? 274 ARG A CZ  1 
ATOM   1651 N NH1 . ARG A 1 274 ? 165.014 187.582 142.847 1.00 53.13  ? 274 ARG A NH1 1 
ATOM   1652 N NH2 . ARG A 1 274 ? 165.980 187.153 140.817 1.00 53.13  ? 274 ARG A NH2 1 
ATOM   1653 N N   . LEU A 1 275 ? 161.605 183.239 143.788 1.00 51.78  ? 275 LEU A N   1 
ATOM   1654 C CA  . LEU A 1 275 ? 162.209 181.969 144.181 1.00 51.78  ? 275 LEU A CA  1 
ATOM   1655 C C   . LEU A 1 275 ? 161.449 180.792 143.585 1.00 51.78  ? 275 LEU A C   1 
ATOM   1656 O O   . LEU A 1 275 ? 162.047 179.896 142.974 1.00 51.78  ? 275 LEU A O   1 
ATOM   1657 C CB  . LEU A 1 275 ? 162.241 181.870 145.709 1.00 51.78  ? 275 LEU A CB  1 
ATOM   1658 C CG  . LEU A 1 275 ? 163.023 180.766 146.428 1.00 51.78  ? 275 LEU A CG  1 
ATOM   1659 C CD1 . LEU A 1 275 ? 163.474 181.270 147.790 1.00 51.78  ? 275 LEU A CD1 1 
ATOM   1660 C CD2 . LEU A 1 275 ? 162.264 179.450 146.585 1.00 51.78  ? 275 LEU A CD2 1 
ATOM   1661 N N   . VAL A 1 276 ? 160.127 180.769 143.768 1.00 46.14  ? 276 VAL A N   1 
ATOM   1662 C CA  . VAL A 1 276 ? 159.365 179.632 143.254 1.00 46.14  ? 276 VAL A CA  1 
ATOM   1663 C C   . VAL A 1 276 ? 159.348 179.643 141.728 1.00 46.14  ? 276 VAL A C   1 
ATOM   1664 O O   . VAL A 1 276 ? 159.388 178.582 141.088 1.00 46.14  ? 276 VAL A O   1 
ATOM   1665 C CB  . VAL A 1 276 ? 157.947 179.583 143.857 1.00 46.14  ? 276 VAL A CB  1 
ATOM   1666 C CG1 . VAL A 1 276 ? 158.023 179.275 145.343 1.00 46.14  ? 276 VAL A CG1 1 
ATOM   1667 C CG2 . VAL A 1 276 ? 157.193 180.870 143.625 1.00 46.14  ? 276 VAL A CG2 1 
ATOM   1668 N N   . LEU A 1 277 ? 159.352 180.836 141.120 1.00 48.63  ? 277 LEU A N   1 
ATOM   1669 C CA  . LEU A 1 277 ? 159.413 180.930 139.666 1.00 48.63  ? 277 LEU A CA  1 
ATOM   1670 C C   . LEU A 1 277 ? 160.732 180.397 139.119 1.00 48.63  ? 277 LEU A C   1 
ATOM   1671 O O   . LEU A 1 277 ? 160.737 179.667 138.122 1.00 48.63  ? 277 LEU A O   1 
ATOM   1672 C CB  . LEU A 1 277 ? 159.204 182.378 139.225 1.00 48.63  ? 277 LEU A CB  1 
ATOM   1673 C CG  . LEU A 1 277 ? 159.128 182.607 137.716 1.00 48.63  ? 277 LEU A CG  1 
ATOM   1674 C CD1 . LEU A 1 277 ? 157.917 181.899 137.130 1.00 48.63  ? 277 LEU A CD1 1 
ATOM   1675 C CD2 . LEU A 1 277 ? 159.098 184.093 137.395 1.00 48.63  ? 277 LEU A CD2 1 
ATOM   1676 N N   . VAL A 1 278 ? 161.860 180.736 139.754 1.00 49.38  ? 278 VAL A N   1 
ATOM   1677 C CA  . VAL A 1 278 ? 163.141 180.277 139.226 1.00 49.38  ? 278 VAL A CA  1 
ATOM   1678 C C   . VAL A 1 278 ? 163.328 178.787 139.497 1.00 49.38  ? 278 VAL A C   1 
ATOM   1679 O O   . VAL A 1 278 ? 163.952 178.088 138.692 1.00 49.38  ? 278 VAL A O   1 
ATOM   1680 C CB  . VAL A 1 278 ? 164.317 181.126 139.765 1.00 49.38  ? 278 VAL A CB  1 
ATOM   1681 C CG1 . VAL A 1 278 ? 164.567 180.905 141.249 1.00 49.38  ? 278 VAL A CG1 1 
ATOM   1682 C CG2 . VAL A 1 278 ? 165.588 180.874 138.960 1.00 49.38  ? 278 VAL A CG2 1 
ATOM   1683 N N   . VAL A 1 279 ? 162.758 178.263 140.588 1.00 49.05  ? 279 VAL A N   1 
ATOM   1684 C CA  . VAL A 1 279 ? 162.812 176.821 140.826 1.00 49.05  ? 279 VAL A CA  1 
ATOM   1685 C C   . VAL A 1 279 ? 162.029 176.073 139.750 1.00 49.05  ? 279 VAL A C   1 
ATOM   1686 O O   . VAL A 1 279 ? 162.522 175.097 139.164 1.00 49.05  ? 279 VAL A O   1 
ATOM   1687 C CB  . VAL A 1 279 ? 162.300 176.492 142.241 1.00 49.05  ? 279 VAL A CB  1 
ATOM   1688 C CG1 . VAL A 1 279 ? 161.880 175.033 142.344 1.00 49.05  ? 279 VAL A CG1 1 
ATOM   1689 C CG2 . VAL A 1 279 ? 163.368 176.807 143.273 1.00 49.05  ? 279 VAL A CG2 1 
ATOM   1690 N N   . VAL A 1 280 ? 160.818 176.553 139.441 1.00 48.46  ? 280 VAL A N   1 
ATOM   1691 C CA  . VAL A 1 280 ? 160.001 175.917 138.408 1.00 48.46  ? 280 VAL A CA  1 
ATOM   1692 C C   . VAL A 1 280 ? 160.664 176.041 137.040 1.00 48.46  ? 280 VAL A C   1 
ATOM   1693 O O   . VAL A 1 280 ? 160.659 175.093 136.247 1.00 48.46  ? 280 VAL A O   1 
ATOM   1694 C CB  . VAL A 1 280 ? 158.579 176.511 138.417 1.00 48.46  ? 280 VAL A CB  1 
ATOM   1695 C CG1 . VAL A 1 280 ? 157.806 176.104 137.176 1.00 48.46  ? 280 VAL A CG1 1 
ATOM   1696 C CG2 . VAL A 1 280 ? 157.835 176.057 139.659 1.00 48.46  ? 280 VAL A CG2 1 
ATOM   1697 N N   . ALA A 1 281 ? 161.272 177.197 136.754 1.00 50.63  ? 281 ALA A N   1 
ATOM   1698 C CA  . ALA A 1 281 ? 161.937 177.398 135.468 1.00 50.63  ? 281 ALA A CA  1 
ATOM   1699 C C   . ALA A 1 281 ? 163.148 176.483 135.314 1.00 50.63  ? 281 ALA A C   1 
ATOM   1700 O O   . ALA A 1 281 ? 163.317 175.840 134.271 1.00 50.63  ? 281 ALA A O   1 
ATOM   1701 C CB  . ALA A 1 281 ? 162.349 178.862 135.315 1.00 50.63  ? 281 ALA A CB  1 
ATOM   1702 N N   . VAL A 1 282 ? 163.987 176.396 136.351 1.00 48.58  ? 282 VAL A N   1 
ATOM   1703 C CA  . VAL A 1 282 ? 165.174 175.548 136.302 1.00 48.58  ? 282 VAL A CA  1 
ATOM   1704 C C   . VAL A 1 282 ? 164.779 174.085 136.149 1.00 48.58  ? 282 VAL A C   1 
ATOM   1705 O O   . VAL A 1 282 ? 165.415 173.332 135.400 1.00 48.58  ? 282 VAL A O   1 
ATOM   1706 C CB  . VAL A 1 282 ? 166.047 175.792 137.551 1.00 48.58  ? 282 VAL A CB  1 
ATOM   1707 C CG1 . VAL A 1 282 ? 167.034 174.658 137.786 1.00 48.58  ? 282 VAL A CG1 1 
ATOM   1708 C CG2 . VAL A 1 282 ? 166.799 177.106 137.412 1.00 48.58  ? 282 VAL A CG2 1 
ATOM   1709 N N   . PHE A 1 283 ? 163.703 173.665 136.819 1.00 46.22  ? 283 PHE A N   1 
ATOM   1710 C CA  . PHE A 1 283 ? 163.237 172.292 136.651 1.00 46.22  ? 283 PHE A CA  1 
ATOM   1711 C C   . PHE A 1 283 ? 162.708 172.051 135.239 1.00 46.22  ? 283 PHE A C   1 
ATOM   1712 O O   . PHE A 1 283 ? 163.155 171.129 134.546 1.00 46.22  ? 283 PHE A O   1 
ATOM   1713 C CB  . PHE A 1 283 ? 162.166 171.979 137.692 1.00 46.22  ? 283 PHE A CB  1 
ATOM   1714 C CG  . PHE A 1 283 ? 161.442 170.687 137.452 1.00 46.22  ? 283 PHE A CG  1 
ATOM   1715 C CD1 . PHE A 1 283 ? 162.130 169.487 137.424 1.00 46.22  ? 283 PHE A CD1 1 
ATOM   1716 C CD2 . PHE A 1 283 ? 160.069 170.670 137.269 1.00 46.22  ? 283 PHE A CD2 1 
ATOM   1717 C CE1 . PHE A 1 283 ? 161.466 168.297 137.210 1.00 46.22  ? 283 PHE A CE1 1 
ATOM   1718 C CE2 . PHE A 1 283 ? 159.399 169.484 137.056 1.00 46.22  ? 283 PHE A CE2 1 
ATOM   1719 C CZ  . PHE A 1 283 ? 160.099 168.296 137.028 1.00 46.22  ? 283 PHE A CZ  1 
ATOM   1720 N N   . VAL A 1 284 ? 161.803 172.913 134.770 1.00 47.95  ? 284 VAL A N   1 
ATOM   1721 C CA  . VAL A 1 284 ? 161.030 172.614 133.567 1.00 47.95  ? 284 VAL A CA  1 
ATOM   1722 C C   . VAL A 1 284 ? 161.877 172.799 132.313 1.00 47.95  ? 284 VAL A C   1 
ATOM   1723 O O   . VAL A 1 284 ? 161.943 171.905 131.463 1.00 47.95  ? 284 VAL A O   1 
ATOM   1724 C CB  . VAL A 1 284 ? 159.754 173.475 133.524 1.00 47.95  ? 284 VAL A CB  1 
ATOM   1725 C CG1 . VAL A 1 284 ? 159.174 173.516 132.117 1.00 47.95  ? 284 VAL A CG1 1 
ATOM   1726 C CG2 . VAL A 1 284 ? 158.724 172.945 134.509 1.00 47.95  ? 284 VAL A CG2 1 
ATOM   1727 N N   . VAL A 1 285 ? 162.539 173.956 132.179 1.00 49.44  ? 285 VAL A N   1 
ATOM   1728 C CA  . VAL A 1 285 ? 163.274 174.272 130.954 1.00 49.44  ? 285 VAL A CA  1 
ATOM   1729 C C   . VAL A 1 285 ? 164.439 173.308 130.748 1.00 49.44  ? 285 VAL A C   1 
ATOM   1730 O O   . VAL A 1 285 ? 164.833 173.025 129.610 1.00 49.44  ? 285 VAL A O   1 
ATOM   1731 C CB  . VAL A 1 285 ? 163.732 175.748 131.000 1.00 49.44  ? 285 VAL A CB  1 
ATOM   1732 C CG1 . VAL A 1 285 ? 164.475 176.157 129.733 1.00 49.44  ? 285 VAL A CG1 1 
ATOM   1733 C CG2 . VAL A 1 285 ? 162.534 176.661 131.210 1.00 49.44  ? 285 VAL A CG2 1 
ATOM   1734 N N   . CYS A 1 286 ? 164.971 172.744 131.831 1.00 54.42  ? 286 CYS A N   1 
ATOM   1735 C CA  . CYS A 1 286 ? 166.074 171.800 131.711 1.00 54.42  ? 286 CYS A CA  1 
ATOM   1736 C C   . CYS A 1 286 ? 165.617 170.349 131.576 1.00 54.42  ? 286 CYS A C   1 
ATOM   1737 O O   . CYS A 1 286 ? 166.278 169.565 130.887 1.00 54.42  ? 286 CYS A O   1 
ATOM   1738 C CB  . CYS A 1 286 ? 167.011 171.941 132.908 1.00 54.42  ? 286 CYS A CB  1 
ATOM   1739 S SG  . CYS A 1 286 ? 168.040 173.426 132.882 1.00 54.42  ? 286 CYS A SG  1 
ATOM   1740 N N   . TRP A 1 287 ? 164.509 169.957 132.211 1.00 51.09  ? 287 TRP A N   1 
ATOM   1741 C CA  . TRP A 1 287 ? 164.059 168.572 132.148 1.00 51.09  ? 287 TRP A CA  1 
ATOM   1742 C C   . TRP A 1 287 ? 163.109 168.277 130.995 1.00 51.09  ? 287 TRP A C   1 
ATOM   1743 O O   . TRP A 1 287 ? 162.894 167.102 130.685 1.00 51.09  ? 287 TRP A O   1 
ATOM   1744 C CB  . TRP A 1 287 ? 163.368 168.183 133.459 1.00 51.09  ? 287 TRP A CB  1 
ATOM   1745 C CG  . TRP A 1 287 ? 164.270 167.664 134.526 1.00 51.09  ? 287 TRP A CG  1 
ATOM   1746 C CD1 . TRP A 1 287 ? 164.790 168.363 135.572 1.00 51.09  ? 287 TRP A CD1 1 
ATOM   1747 C CD2 . TRP A 1 287 ? 164.722 166.315 134.679 1.00 51.09  ? 287 TRP A CD2 1 
ATOM   1748 N NE1 . TRP A 1 287 ? 165.565 167.541 136.352 1.00 51.09  ? 287 TRP A NE1 1 
ATOM   1749 C CE2 . TRP A 1 287 ? 165.535 166.276 135.827 1.00 51.09  ? 287 TRP A CE2 1 
ATOM   1750 C CE3 . TRP A 1 287 ? 164.526 165.138 133.951 1.00 51.09  ? 287 TRP A CE3 1 
ATOM   1751 C CZ2 . TRP A 1 287 ? 166.152 165.107 136.265 1.00 51.09  ? 287 TRP A CZ2 1 
ATOM   1752 C CZ3 . TRP A 1 287 ? 165.138 163.980 134.385 1.00 51.09  ? 287 TRP A CZ3 1 
ATOM   1753 C CH2 . TRP A 1 287 ? 165.942 163.972 135.532 1.00 51.09  ? 287 TRP A CH2 1 
ATOM   1754 N N   . THR A 1 288 ? 162.533 169.292 130.360 1.00 47.72  ? 288 THR A N   1 
ATOM   1755 C CA  . THR A 1 288 ? 161.501 169.068 129.352 1.00 47.72  ? 288 THR A CA  1 
ATOM   1756 C C   . THR A 1 288 ? 162.006 168.694 127.950 1.00 47.72  ? 288 THR A C   1 
ATOM   1757 O O   . THR A 1 288 ? 161.440 167.758 127.363 1.00 47.72  ? 288 THR A O   1 
ATOM   1758 C CB  . THR A 1 288 ? 160.580 170.291 129.294 1.00 47.72  ? 288 THR A CB  1 
ATOM   1759 O OG1 . THR A 1 288 ? 160.241 170.677 130.629 1.00 47.72  ? 288 THR A OG1 1 
ATOM   1760 C CG2 . THR A 1 288 ? 159.295 169.943 128.598 1.00 47.72  ? 288 THR A CG2 1 
ATOM   1761 N N   . PRO A 1 289 ? 163.034 169.352 127.363 1.00 50.43  ? 289 PRO A N   1 
ATOM   1762 C CA  . PRO A 1 289 ? 163.451 168.955 125.999 1.00 50.43  ? 289 PRO A CA  1 
ATOM   1763 C C   . PRO A 1 289 ? 163.927 167.518 125.884 1.00 50.43  ? 289 PRO A C   1 
ATOM   1764 O O   . PRO A 1 289 ? 163.868 166.945 124.788 1.00 50.43  ? 289 PRO A O   1 
ATOM   1765 C CB  . PRO A 1 289 ? 164.582 169.940 125.674 1.00 50.43  ? 289 PRO A CB  1 
ATOM   1766 C CG  . PRO A 1 289 ? 164.321 171.097 126.526 1.00 50.43  ? 289 PRO A CG  1 
ATOM   1767 C CD  . PRO A 1 289 ? 163.827 170.519 127.802 1.00 50.43  ? 289 PRO A CD  1 
ATOM   1768 N N   . ILE A 1 290 ? 164.370 166.918 126.992 1.00 52.01  ? 290 ILE A N   1 
ATOM   1769 C CA  . ILE A 1 290 ? 164.531 165.468 127.057 1.00 52.01  ? 290 ILE A CA  1 
ATOM   1770 C C   . ILE A 1 290 ? 163.217 164.781 126.706 1.00 52.01  ? 290 ILE A C   1 
ATOM   1771 O O   . ILE A 1 290 ? 163.176 163.860 125.882 1.00 52.01  ? 290 ILE A O   1 
ATOM   1772 C CB  . ILE A 1 290 ? 165.026 165.051 128.455 1.00 52.01  ? 290 ILE A CB  1 
ATOM   1773 C CG1 . ILE A 1 290 ? 166.532 165.286 128.594 1.00 52.01  ? 290 ILE A CG1 1 
ATOM   1774 C CG2 . ILE A 1 290 ? 164.682 163.598 128.750 1.00 52.01  ? 290 ILE A CG2 1 
ATOM   1775 C CD1 . ILE A 1 290 ? 167.387 164.259 127.881 1.00 52.01  ? 290 ILE A CD1 1 
ATOM   1776 N N   . HIS A 1 291 ? 162.119 165.231 127.314 1.00 46.59  ? 291 HIS A N   1 
ATOM   1777 C CA  . HIS A 1 291 ? 160.844 164.567 127.077 1.00 46.59  ? 291 HIS A CA  1 
ATOM   1778 C C   . HIS A 1 291 ? 160.347 164.808 125.659 1.00 46.59  ? 291 HIS A C   1 
ATOM   1779 O O   . HIS A 1 291 ? 159.772 163.901 125.049 1.00 46.59  ? 291 HIS A O   1 
ATOM   1780 C CB  . HIS A 1 291 ? 159.816 165.009 128.111 1.00 46.59  ? 291 HIS A CB  1 
ATOM   1781 C CG  . HIS A 1 291 ? 159.839 164.185 129.359 1.00 46.59  ? 291 HIS A CG  1 
ATOM   1782 N ND1 . HIS A 1 291 ? 158.773 163.410 129.761 1.00 46.59  ? 291 HIS A ND1 1 
ATOM   1783 C CD2 . HIS A 1 291 ? 160.810 163.997 130.283 1.00 46.59  ? 291 HIS A CD2 1 
ATOM   1784 C CE1 . HIS A 1 291 ? 159.080 162.793 130.887 1.00 46.59  ? 291 HIS A CE1 1 
ATOM   1785 N NE2 . HIS A 1 291 ? 160.310 163.132 131.226 1.00 46.59  ? 291 HIS A NE2 1 
ATOM   1786 N N   . ILE A 1 292 ? 160.601 166.000 125.100 1.00 52.24  ? 292 ILE A N   1 
ATOM   1787 C CA  . ILE A 1 292 ? 160.331 166.205 123.671 1.00 52.24  ? 292 ILE A CA  1 
ATOM   1788 C C   . ILE A 1 292 ? 161.143 165.241 122.810 1.00 52.24  ? 292 ILE A C   1 
ATOM   1789 O O   . ILE A 1 292 ? 160.602 164.630 121.882 1.00 52.24  ? 292 ILE A O   1 
ATOM   1790 C CB  . ILE A 1 292 ? 160.546 167.673 123.228 1.00 52.24  ? 292 ILE A CB  1 
ATOM   1791 C CG1 . ILE A 1 292 ? 159.502 168.632 123.822 1.00 52.24  ? 292 ILE A CG1 1 
ATOM   1792 C CG2 . ILE A 1 292 ? 160.589 167.813 121.702 1.00 52.24  ? 292 ILE A CG2 1 
ATOM   1793 C CD1 . ILE A 1 292 ? 159.831 169.265 125.102 1.00 52.24  ? 292 ILE A CD1 1 
ATOM   1794 N N   . PHE A 1 293 ? 162.432 165.055 123.116 1.00 54.89  ? 293 PHE A N   1 
ATOM   1795 C CA  . PHE A 1 293 ? 163.275 164.233 122.250 1.00 54.89  ? 293 PHE A CA  1 
ATOM   1796 C C   . PHE A 1 293 ? 162.847 162.767 122.280 1.00 54.89  ? 293 PHE A C   1 
ATOM   1797 O O   . PHE A 1 293 ? 162.638 162.148 121.228 1.00 54.89  ? 293 PHE A O   1 
ATOM   1798 C CB  . PHE A 1 293 ? 164.741 164.360 122.658 1.00 54.89  ? 293 PHE A CB  1 
ATOM   1799 C CG  . PHE A 1 293 ? 165.700 163.825 121.631 1.00 54.89  ? 293 PHE A CG  1 
ATOM   1800 C CD1 . PHE A 1 293 ? 166.101 164.619 120.565 1.00 54.89  ? 293 PHE A CD1 1 
ATOM   1801 C CD2 . PHE A 1 293 ? 166.163 162.521 121.698 1.00 54.89  ? 293 PHE A CD2 1 
ATOM   1802 C CE1 . PHE A 1 293 ? 166.978 164.134 119.609 1.00 54.89  ? 293 PHE A CE1 1 
ATOM   1803 C CE2 . PHE A 1 293 ? 167.029 162.028 120.736 1.00 54.89  ? 293 PHE A CE2 1 
ATOM   1804 C CZ  . PHE A 1 293 ? 167.438 162.836 119.697 1.00 54.89  ? 293 PHE A CZ  1 
ATOM   1805 N N   . ILE A 1 294 ? 162.695 162.200 123.480 1.00 52.50  ? 294 ILE A N   1 
ATOM   1806 C CA  . ILE A 1 294 ? 162.275 160.801 123.581 1.00 52.50  ? 294 ILE A CA  1 
ATOM   1807 C C   . ILE A 1 294 ? 160.824 160.595 123.124 1.00 52.50  ? 294 ILE A C   1 
ATOM   1808 O O   . ILE A 1 294 ? 160.527 159.585 122.473 1.00 52.50  ? 294 ILE A O   1 
ATOM   1809 C CB  . ILE A 1 294 ? 162.568 160.224 124.991 1.00 52.50  ? 294 ILE A CB  1 
ATOM   1810 C CG1 . ILE A 1 294 ? 164.084 160.079 125.236 1.00 52.50  ? 294 ILE A CG1 1 
ATOM   1811 C CG2 . ILE A 1 294 ? 161.924 158.861 125.212 1.00 52.50  ? 294 ILE A CG2 1 
ATOM   1812 C CD1 . ILE A 1 294 ? 164.827 161.218 125.830 1.00 52.50  ? 294 ILE A CD1 1 
ATOM   1813 N N   . LEU A 1 295 ? 159.902 161.532 123.384 1.00 51.41  ? 295 LEU A N   1 
ATOM   1814 C CA  . LEU A 1 295 ? 158.544 161.315 122.889 1.00 51.41  ? 295 LEU A CA  1 
ATOM   1815 C C   . LEU A 1 295 ? 158.453 161.513 121.377 1.00 51.41  ? 295 LEU A C   1 
ATOM   1816 O O   . LEU A 1 295 ? 157.585 160.917 120.728 1.00 51.41  ? 295 LEU A O   1 
ATOM   1817 C CB  . LEU A 1 295 ? 157.551 162.218 123.624 1.00 51.41  ? 295 LEU A CB  1 
ATOM   1818 C CG  . LEU A 1 295 ? 156.059 161.969 123.368 1.00 51.41  ? 295 LEU A CG  1 
ATOM   1819 C CD1 . LEU A 1 295 ? 155.287 162.012 124.662 1.00 51.41  ? 295 LEU A CD1 1 
ATOM   1820 C CD2 . LEU A 1 295 ? 155.490 162.994 122.396 1.00 51.41  ? 295 LEU A CD2 1 
ATOM   1821 N N   . VAL A 1 296 ? 159.335 162.326 120.793 1.00 53.37  ? 296 VAL A N   1 
ATOM   1822 C CA  . VAL A 1 296 ? 159.386 162.433 119.340 1.00 53.37  ? 296 VAL A CA  1 
ATOM   1823 C C   . VAL A 1 296 ? 159.936 161.149 118.741 1.00 53.37  ? 296 VAL A C   1 
ATOM   1824 O O   . VAL A 1 296 ? 159.418 160.641 117.739 1.00 53.37  ? 296 VAL A O   1 
ATOM   1825 C CB  . VAL A 1 296 ? 160.217 163.660 118.921 1.00 53.37  ? 296 VAL A CB  1 
ATOM   1826 N N   . GLU A 1 297 ? 160.982 160.594 119.346 1.00 52.93  ? 297 GLU A N   1 
ATOM   1827 C CA  . GLU A 1 297 ? 161.470 159.295 118.888 1.00 52.93  ? 297 GLU A CA  1 
ATOM   1828 C C   . GLU A 1 297 ? 160.815 158.152 119.655 1.00 52.93  ? 297 GLU A C   1 
ATOM   1829 O O   . GLU A 1 297 ? 161.471 157.210 120.094 1.00 52.93  ? 297 GLU A O   1 
ATOM   1830 C CB  . GLU A 1 297 ? 162.987 159.240 119.017 1.00 52.93  ? 297 GLU A CB  1 
ATOM   1831 N N   . ALA A 1 298 ? 159.497 158.235 119.824 1.00 58.05  ? 298 ALA A N   1 
ATOM   1832 C CA  . ALA A 1 298 ? 158.693 157.106 120.272 1.00 58.05  ? 298 ALA A CA  1 
ATOM   1833 C C   . ALA A 1 298 ? 157.530 156.834 119.330 1.00 58.05  ? 298 ALA A C   1 
ATOM   1834 O O   . ALA A 1 298 ? 157.334 155.688 118.912 1.00 58.05  ? 298 ALA A O   1 
ATOM   1835 C CB  . ALA A 1 298 ? 158.187 157.346 121.699 1.00 58.05  ? 298 ALA A CB  1 
ATOM   1836 N N   . LEU A 1 299 ? 156.758 157.866 118.974 1.00 61.39  ? 299 LEU A N   1 
ATOM   1837 C CA  . LEU A 1 299 ? 155.480 157.659 118.299 1.00 61.39  ? 299 LEU A CA  1 
ATOM   1838 C C   . LEU A 1 299 ? 155.672 157.280 116.837 1.00 61.39  ? 299 LEU A C   1 
ATOM   1839 O O   . LEU A 1 299 ? 154.968 156.406 116.319 1.00 61.39  ? 299 LEU A O   1 
ATOM   1840 C CB  . LEU A 1 299 ? 154.614 158.913 118.436 1.00 61.39  ? 299 LEU A CB  1 
ATOM   1841 C CG  . LEU A 1 299 ? 153.127 158.836 118.066 1.00 61.39  ? 299 LEU A CG  1 
ATOM   1842 C CD1 . LEU A 1 299 ? 152.321 159.695 119.026 1.00 61.39  ? 299 LEU A CD1 1 
ATOM   1843 C CD2 . LEU A 1 299 ? 152.865 159.280 116.631 1.00 61.39  ? 299 LEU A CD2 1 
ATOM   1844 N N   . GLY A 1 300 ? 156.604 157.929 116.153 1.00 66.68  ? 300 GLY A N   1 
ATOM   1845 C CA  . GLY A 1 300 ? 156.858 157.595 114.769 1.00 66.68  ? 300 GLY A CA  1 
ATOM   1846 C C   . GLY A 1 300 ? 158.124 156.786 114.602 1.00 66.68  ? 300 GLY A C   1 
ATOM   1847 O O   . GLY A 1 300 ? 158.243 155.679 115.137 1.00 66.68  ? 300 GLY A O   1 
ATOM   1848 N N   . SER A 1 301 ? 159.082 157.336 113.864 1.00 80.72  ? 301 SER A N   1 
ATOM   1849 C CA  . SER A 1 301 ? 160.371 156.691 113.669 1.00 80.72  ? 301 SER A CA  1 
ATOM   1850 C C   . SER A 1 301 ? 161.436 157.771 113.571 1.00 80.72  ? 301 SER A C   1 
ATOM   1851 O O   . SER A 1 301 ? 161.177 158.861 113.054 1.00 80.72  ? 301 SER A O   1 
ATOM   1852 C CB  . SER A 1 301 ? 160.377 155.812 112.413 1.00 80.72  ? 301 SER A CB  1 
ATOM   1853 N N   . THR A 1 302 ? 162.627 157.465 114.076 1.00 84.70  ? 302 THR A N   1 
ATOM   1854 C CA  . THR A 1 302 ? 163.731 158.419 114.059 1.00 84.70  ? 302 THR A CA  1 
ATOM   1855 C C   . THR A 1 302 ? 165.028 157.631 113.962 1.00 84.70  ? 302 THR A C   1 
ATOM   1856 O O   . THR A 1 302 ? 165.335 156.830 114.851 1.00 84.70  ? 302 THR A O   1 
ATOM   1857 C CB  . THR A 1 302 ? 163.716 159.302 115.303 1.00 84.70  ? 302 THR A CB  1 
ATOM   1858 N N   . SER A 1 303 ? 165.780 157.852 112.889 1.00 89.29  ? 303 SER A N   1 
ATOM   1859 C CA  . SER A 1 303 ? 167.056 157.177 112.696 1.00 89.29  ? 303 SER A CA  1 
ATOM   1860 C C   . SER A 1 303 ? 168.147 157.930 113.456 1.00 89.29  ? 303 SER A C   1 
ATOM   1861 O O   . SER A 1 303 ? 167.891 158.922 114.145 1.00 89.29  ? 303 SER A O   1 
ATOM   1862 C CB  . SER A 1 303 ? 167.369 157.057 111.207 1.00 89.29  ? 303 SER A CB  1 
ATOM   1863 N N   . HIS A 1 304 ? 169.392 157.468 113.328 1.00 91.41  ? 304 HIS A N   1 
ATOM   1864 C CA  . HIS A 1 304 ? 170.524 158.087 114.016 1.00 91.41  ? 304 HIS A CA  1 
ATOM   1865 C C   . HIS A 1 304 ? 171.076 159.228 113.159 1.00 91.41  ? 304 HIS A C   1 
ATOM   1866 O O   . HIS A 1 304 ? 172.166 159.162 112.587 1.00 91.41  ? 304 HIS A O   1 
ATOM   1867 C CB  . HIS A 1 304 ? 171.591 157.047 114.325 1.00 91.41  ? 304 HIS A CB  1 
ATOM   1868 N N   . SER A 1 305 ? 170.287 160.295 113.074 1.00 85.78  ? 305 SER A N   1 
ATOM   1869 C CA  . SER A 1 305 ? 170.704 161.477 112.334 1.00 85.78  ? 305 SER A CA  1 
ATOM   1870 C C   . SER A 1 305 ? 171.794 162.222 113.097 1.00 85.78  ? 305 SER A C   1 
ATOM   1871 O O   . SER A 1 305 ? 171.918 162.101 114.317 1.00 85.78  ? 305 SER A O   1 
ATOM   1872 C CB  . SER A 1 305 ? 169.511 162.399 112.080 1.00 85.78  ? 305 SER A CB  1 
ATOM   1873 N N   . THR A 1 306 ? 172.608 162.982 112.356 1.00 80.86  ? 306 THR A N   1 
ATOM   1874 C CA  . THR A 1 306 ? 173.673 163.754 112.990 1.00 80.86  ? 306 THR A CA  1 
ATOM   1875 C C   . THR A 1 306 ? 173.104 164.896 113.820 1.00 80.86  ? 306 THR A C   1 
ATOM   1876 O O   . THR A 1 306 ? 173.643 165.231 114.882 1.00 80.86  ? 306 THR A O   1 
ATOM   1877 C CB  . THR A 1 306 ? 174.650 164.282 111.940 1.00 80.86  ? 306 THR A CB  1 
ATOM   1878 O OG1 . THR A 1 306 ? 173.999 165.259 111.120 1.00 80.86  ? 306 THR A OG1 1 
ATOM   1879 C CG2 . THR A 1 306 ? 175.161 163.148 111.066 1.00 80.86  ? 306 THR A CG2 1 
ATOM   1880 N N   . ALA A 1 307 ? 172.015 165.510 113.352 1.00 80.33  ? 307 ALA A N   1 
ATOM   1881 C CA  . ALA A 1 307 ? 171.354 166.537 114.149 1.00 80.33  ? 307 ALA A CA  1 
ATOM   1882 C C   . ALA A 1 307 ? 170.651 165.939 115.360 1.00 80.33  ? 307 ALA A C   1 
ATOM   1883 O O   . ALA A 1 307 ? 170.468 166.630 116.368 1.00 80.33  ? 307 ALA A O   1 
ATOM   1884 C CB  . ALA A 1 307 ? 170.357 167.321 113.293 1.00 80.33  ? 307 ALA A CB  1 
ATOM   1885 N N   . ALA A 1 308 ? 170.244 164.669 115.282 1.00 76.74  ? 308 ALA A N   1 
ATOM   1886 C CA  . ALA A 1 308 ? 169.524 164.057 116.395 1.00 76.74  ? 308 ALA A CA  1 
ATOM   1887 C C   . ALA A 1 308 ? 170.441 163.787 117.582 1.00 76.74  ? 308 ALA A C   1 
ATOM   1888 O O   . ALA A 1 308 ? 170.105 164.134 118.720 1.00 76.74  ? 308 ALA A O   1 
ATOM   1889 C CB  . ALA A 1 308 ? 168.847 162.767 115.935 1.00 76.74  ? 308 ALA A CB  1 
ATOM   1890 N N   . LEU A 1 309 ? 171.608 163.184 117.336 1.00 77.04  ? 309 LEU A N   1 
ATOM   1891 C CA  . LEU A 1 309 ? 172.506 162.829 118.433 1.00 77.04  ? 309 LEU A CA  1 
ATOM   1892 C C   . LEU A 1 309 ? 173.122 164.069 119.068 1.00 77.04  ? 309 LEU A C   1 
ATOM   1893 O O   . LEU A 1 309 ? 173.327 164.110 120.288 1.00 77.04  ? 309 LEU A O   1 
ATOM   1894 C CB  . LEU A 1 309 ? 173.602 161.879 117.951 1.00 77.04  ? 309 LEU A CB  1 
ATOM   1895 C CG  . LEU A 1 309 ? 173.327 160.367 117.848 1.00 77.04  ? 309 LEU A CG  1 
ATOM   1896 C CD1 . LEU A 1 309 ? 173.007 159.734 119.204 1.00 77.04  ? 309 LEU A CD1 1 
ATOM   1897 C CD2 . LEU A 1 309 ? 172.269 159.997 116.825 1.00 77.04  ? 309 LEU A CD2 1 
ATOM   1898 N N   . SER A 1 310 ? 173.435 165.082 118.254 1.00 76.24  ? 310 SER A N   1 
ATOM   1899 C CA  . SER A 1 310 ? 173.923 166.352 118.783 1.00 76.24  ? 310 SER A CA  1 
ATOM   1900 C C   . SER A 1 310 ? 172.883 167.011 119.680 1.00 76.24  ? 310 SER A C   1 
ATOM   1901 O O   . SER A 1 310 ? 173.211 167.506 120.766 1.00 76.24  ? 310 SER A O   1 
ATOM   1902 C CB  . SER A 1 310 ? 174.305 167.279 117.629 1.00 76.24  ? 310 SER A CB  1 
ATOM   1903 O OG  . SER A 1 310 ? 173.189 167.542 116.795 1.00 76.24  ? 310 SER A OG  1 
ATOM   1904 N N   . SER A 1 311 ? 171.618 167.001 119.255 1.00 72.84  ? 311 SER A N   1 
ATOM   1905 C CA  . SER A 1 311 ? 170.542 167.443 120.132 1.00 72.84  ? 311 SER A CA  1 
ATOM   1906 C C   . SER A 1 311 ? 170.359 166.494 121.310 1.00 72.84  ? 311 SER A C   1 
ATOM   1907 O O   . SER A 1 311 ? 170.011 166.937 122.410 1.00 72.84  ? 311 SER A O   1 
ATOM   1908 C CB  . SER A 1 311 ? 169.239 167.572 119.345 1.00 72.84  ? 311 SER A CB  1 
ATOM   1909 N N   . TYR A 1 312 ? 170.589 165.194 121.101 1.00 71.46  ? 312 TYR A N   1 
ATOM   1910 C CA  . TYR A 1 312 ? 170.487 164.226 122.191 1.00 71.46  ? 312 TYR A CA  1 
ATOM   1911 C C   . TYR A 1 312 ? 171.528 164.489 123.269 1.00 71.46  ? 312 TYR A C   1 
ATOM   1912 O O   . TYR A 1 312 ? 171.200 164.543 124.459 1.00 71.46  ? 312 TYR A O   1 
ATOM   1913 C CB  . TYR A 1 312 ? 170.629 162.806 121.647 1.00 71.46  ? 312 TYR A CB  1 
ATOM   1914 C CG  . TYR A 1 312 ? 170.425 161.718 122.676 1.00 71.46  ? 312 TYR A CG  1 
ATOM   1915 C CD1 . TYR A 1 312 ? 169.199 161.540 123.297 1.00 71.46  ? 312 TYR A CD1 1 
ATOM   1916 C CD2 . TYR A 1 312 ? 171.458 160.852 123.008 1.00 71.46  ? 312 TYR A CD2 1 
ATOM   1917 C CE1 . TYR A 1 312 ? 169.006 160.541 124.227 1.00 71.46  ? 312 TYR A CE1 1 
ATOM   1918 C CE2 . TYR A 1 312 ? 171.276 159.847 123.939 1.00 71.46  ? 312 TYR A CE2 1 
ATOM   1919 C CZ  . TYR A 1 312 ? 170.048 159.698 124.544 1.00 71.46  ? 312 TYR A CZ  1 
ATOM   1920 O OH  . TYR A 1 312 ? 169.857 158.702 125.473 1.00 71.46  ? 312 TYR A OH  1 
ATOM   1921 N N   . TYR A 1 313 ? 172.788 164.671 122.872 1.00 73.25  ? 313 TYR A N   1 
ATOM   1922 C CA  . TYR A 1 313 ? 173.825 164.971 123.854 1.00 73.25  ? 313 TYR A CA  1 
ATOM   1923 C C   . TYR A 1 313 ? 173.651 166.364 124.447 1.00 73.25  ? 313 TYR A C   1 
ATOM   1924 O O   . TYR A 1 313 ? 174.010 166.595 125.606 1.00 73.25  ? 313 TYR A O   1 
ATOM   1925 C CB  . TYR A 1 313 ? 175.215 164.801 123.238 1.00 73.25  ? 313 TYR A CB  1 
ATOM   1926 C CG  . TYR A 1 313 ? 175.468 163.412 122.695 1.00 73.25  ? 313 TYR A CG  1 
ATOM   1927 C CD1 . TYR A 1 313 ? 175.119 162.290 123.435 1.00 73.25  ? 313 TYR A CD1 1 
ATOM   1928 C CD2 . TYR A 1 313 ? 176.072 163.220 121.459 1.00 73.25  ? 313 TYR A CD2 1 
ATOM   1929 C CE1 . TYR A 1 313 ? 175.349 161.017 122.956 1.00 73.25  ? 313 TYR A CE1 1 
ATOM   1930 C CE2 . TYR A 1 313 ? 176.301 161.947 120.967 1.00 73.25  ? 313 TYR A CE2 1 
ATOM   1931 C CZ  . TYR A 1 313 ? 175.941 160.850 121.723 1.00 73.25  ? 313 TYR A CZ  1 
ATOM   1932 O OH  . TYR A 1 313 ? 176.170 159.580 121.247 1.00 73.25  ? 313 TYR A OH  1 
ATOM   1933 N N   . PHE A 1 314 ? 173.077 167.300 123.683 1.00 69.93  ? 314 PHE A N   1 
ATOM   1934 C CA  . PHE A 1 314 ? 172.767 168.613 124.243 1.00 69.93  ? 314 PHE A CA  1 
ATOM   1935 C C   . PHE A 1 314 ? 171.710 168.507 125.340 1.00 69.93  ? 314 PHE A C   1 
ATOM   1936 O O   . PHE A 1 314 ? 171.836 169.123 126.408 1.00 69.93  ? 314 PHE A O   1 
ATOM   1937 C CB  . PHE A 1 314 ? 172.302 169.550 123.126 1.00 69.93  ? 314 PHE A CB  1 
ATOM   1938 C CG  . PHE A 1 314 ? 172.055 170.962 123.574 1.00 69.93  ? 314 PHE A CG  1 
ATOM   1939 C CD1 . PHE A 1 314 ? 173.119 171.810 123.839 1.00 69.93  ? 314 PHE A CD1 1 
ATOM   1940 C CD2 . PHE A 1 314 ? 170.766 171.444 123.719 1.00 69.93  ? 314 PHE A CD2 1 
ATOM   1941 C CE1 . PHE A 1 314 ? 172.901 173.113 124.247 1.00 69.93  ? 314 PHE A CE1 1 
ATOM   1942 C CE2 . PHE A 1 314 ? 170.541 172.746 124.127 1.00 69.93  ? 314 PHE A CE2 1 
ATOM   1943 C CZ  . PHE A 1 314 ? 171.610 173.581 124.391 1.00 69.93  ? 314 PHE A CZ  1 
ATOM   1944 N N   . CYS A 1 315 ? 170.675 167.699 125.102 1.00 67.31  ? 315 CYS A N   1 
ATOM   1945 C CA  . CYS A 1 315 ? 169.626 167.505 126.097 1.00 67.31  ? 315 CYS A CA  1 
ATOM   1946 C C   . CYS A 1 315 ? 170.143 166.738 127.310 1.00 67.31  ? 315 CYS A C   1 
ATOM   1947 O O   . CYS A 1 315 ? 169.734 167.017 128.443 1.00 67.31  ? 315 CYS A O   1 
ATOM   1948 C CB  . CYS A 1 315 ? 168.440 166.785 125.460 1.00 67.31  ? 315 CYS A CB  1 
ATOM   1949 S SG  . CYS A 1 315 ? 167.482 167.801 124.316 1.00 67.31  ? 315 CYS A SG  1 
ATOM   1950 N N   . ILE A 1 316 ? 171.041 165.772 127.094 1.00 67.67  ? 316 ILE A N   1 
ATOM   1951 C CA  . ILE A 1 316 ? 171.677 165.073 128.210 1.00 67.67  ? 316 ILE A CA  1 
ATOM   1952 C C   . ILE A 1 316 ? 172.543 166.032 129.022 1.00 67.67  ? 316 ILE A C   1 
ATOM   1953 O O   . ILE A 1 316 ? 172.573 165.970 130.260 1.00 67.67  ? 316 ILE A O   1 
ATOM   1954 C CB  . ILE A 1 316 ? 172.484 163.866 127.690 1.00 67.67  ? 316 ILE A CB  1 
ATOM   1955 C CG1 . ILE A 1 316 ? 171.544 162.806 127.121 1.00 67.67  ? 316 ILE A CG1 1 
ATOM   1956 C CG2 . ILE A 1 316 ? 173.344 163.249 128.785 1.00 67.67  ? 316 ILE A CG2 1 
ATOM   1957 C CD1 . ILE A 1 316 ? 170.545 162.303 128.116 1.00 67.67  ? 316 ILE A CD1 1 
ATOM   1958 N N   . ALA A 1 317 ? 173.241 166.946 128.342 1.00 68.60  ? 317 ALA A N   1 
ATOM   1959 C CA  . ALA A 1 317 ? 174.043 167.946 129.037 1.00 68.60  ? 317 ALA A CA  1 
ATOM   1960 C C   . ALA A 1 317 ? 173.170 168.849 129.897 1.00 68.60  ? 317 ALA A C   1 
ATOM   1961 O O   . ALA A 1 317 ? 173.529 169.173 131.032 1.00 68.60  ? 317 ALA A O   1 
ATOM   1962 C CB  . ALA A 1 317 ? 174.842 168.767 128.026 1.00 68.60  ? 317 ALA A CB  1 
ATOM   1963 N N   . LEU A 1 318 ? 172.008 169.253 129.375 1.00 68.35  ? 318 LEU A N   1 
ATOM   1964 C CA  . LEU A 1 318 ? 171.079 170.050 130.179 1.00 68.35  ? 318 LEU A CA  1 
ATOM   1965 C C   . LEU A 1 318 ? 170.529 169.255 131.363 1.00 68.35  ? 318 LEU A C   1 
ATOM   1966 O O   . LEU A 1 318 ? 170.438 169.776 132.487 1.00 68.35  ? 318 LEU A O   1 
ATOM   1967 C CB  . LEU A 1 318 ? 169.934 170.563 129.307 1.00 68.35  ? 318 LEU A CB  1 
ATOM   1968 C CG  . LEU A 1 318 ? 170.306 171.564 128.213 1.00 68.35  ? 318 LEU A CG  1 
ATOM   1969 C CD1 . LEU A 1 318 ? 169.080 171.939 127.399 1.00 68.35  ? 318 LEU A CD1 1 
ATOM   1970 C CD2 . LEU A 1 318 ? 170.955 172.798 128.815 1.00 68.35  ? 318 LEU A CD2 1 
ATOM   1971 N N   . GLY A 1 319 ? 170.167 167.990 131.130 1.00 65.84  ? 319 GLY A N   1 
ATOM   1972 C CA  . GLY A 1 319 ? 169.598 167.155 132.173 1.00 65.84  ? 319 GLY A CA  1 
ATOM   1973 C C   . GLY A 1 319 ? 170.607 166.660 133.183 1.00 65.84  ? 319 GLY A C   1 
ATOM   1974 O O   . GLY A 1 319 ? 170.223 166.016 134.164 1.00 65.84  ? 319 GLY A O   1 
ATOM   1975 N N   . TYR A 1 320 ? 171.892 166.904 132.942 1.00 72.17  ? 320 TYR A N   1 
ATOM   1976 C CA  . TYR A 1 320 ? 172.901 166.752 133.981 1.00 72.17  ? 320 TYR A CA  1 
ATOM   1977 C C   . TYR A 1 320 ? 173.285 168.078 134.624 1.00 72.17  ? 320 TYR A C   1 
ATOM   1978 O O   . TYR A 1 320 ? 173.628 168.104 135.812 1.00 72.17  ? 320 TYR A O   1 
ATOM   1979 C CB  . TYR A 1 320 ? 174.157 166.081 133.415 1.00 72.17  ? 320 TYR A CB  1 
ATOM   1980 C CG  . TYR A 1 320 ? 174.105 164.569 133.448 1.00 72.17  ? 320 TYR A CG  1 
ATOM   1981 C CD1 . TYR A 1 320 ? 173.934 163.887 134.645 1.00 72.17  ? 320 TYR A CD1 1 
ATOM   1982 C CD2 . TYR A 1 320 ? 174.234 163.826 132.282 1.00 72.17  ? 320 TYR A CD2 1 
ATOM   1983 C CE1 . TYR A 1 320 ? 173.886 162.506 134.679 1.00 72.17  ? 320 TYR A CE1 1 
ATOM   1984 C CE2 . TYR A 1 320 ? 174.193 162.446 132.306 1.00 72.17  ? 320 TYR A CE2 1 
ATOM   1985 C CZ  . TYR A 1 320 ? 174.016 161.793 133.506 1.00 72.17  ? 320 TYR A CZ  1 
ATOM   1986 O OH  . TYR A 1 320 ? 173.973 160.419 133.536 1.00 72.17  ? 320 TYR A OH  1 
ATOM   1987 N N   . THR A 1 321 ? 173.213 169.178 133.868 1.00 73.28  ? 321 THR A N   1 
ATOM   1988 C CA  . THR A 1 321 ? 173.520 170.495 134.414 1.00 73.28  ? 321 THR A CA  1 
ATOM   1989 C C   . THR A 1 321 ? 172.505 170.918 135.464 1.00 73.28  ? 321 THR A C   1 
ATOM   1990 O O   . THR A 1 321 ? 172.876 171.561 136.452 1.00 73.28  ? 321 THR A O   1 
ATOM   1991 C CB  . THR A 1 321 ? 173.578 171.530 133.290 1.00 73.28  ? 321 THR A CB  1 
ATOM   1992 O OG1 . THR A 1 321 ? 174.307 170.992 132.181 1.00 73.28  ? 321 THR A OG1 1 
ATOM   1993 C CG2 . THR A 1 321 ? 174.263 172.805 133.761 1.00 73.28  ? 321 THR A CG2 1 
ATOM   1994 N N   . ASN A 1 322 ? 171.228 170.578 135.271 1.00 70.07  ? 322 ASN A N   1 
ATOM   1995 C CA  . ASN A 1 322 ? 170.231 170.916 136.287 1.00 70.07  ? 322 ASN A CA  1 
ATOM   1996 C C   . ASN A 1 322 ? 170.481 170.161 137.592 1.00 70.07  ? 322 ASN A C   1 
ATOM   1997 O O   . ASN A 1 322 ? 170.378 170.738 138.682 1.00 70.07  ? 322 ASN A O   1 
ATOM   1998 C CB  . ASN A 1 322 ? 168.824 170.654 135.751 1.00 70.07  ? 322 ASN A CB  1 
ATOM   1999 C CG  . ASN A 1 322 ? 168.646 169.249 135.223 1.00 70.07  ? 322 ASN A CG  1 
ATOM   2000 O OD1 . ASN A 1 322 ? 169.482 168.381 135.440 1.00 70.07  ? 322 ASN A OD1 1 
ATOM   2001 N ND2 . ASN A 1 322 ? 167.577 169.034 134.475 1.00 70.07  ? 322 ASN A ND2 1 
ATOM   2002 N N   . SER A 1 323 ? 170.828 168.872 137.497 1.00 73.87  ? 323 SER A N   1 
ATOM   2003 C CA  . SER A 1 323 ? 171.171 168.095 138.683 1.00 73.87  ? 323 SER A CA  1 
ATOM   2004 C C   . SER A 1 323 ? 172.454 168.582 139.338 1.00 73.87  ? 323 SER A C   1 
ATOM   2005 O O   . SER A 1 323 ? 172.587 168.477 140.561 1.00 73.87  ? 323 SER A O   1 
ATOM   2006 C CB  . SER A 1 323 ? 171.303 166.613 138.332 1.00 73.87  ? 323 SER A CB  1 
ATOM   2007 O OG  . SER A 1 323 ? 170.062 166.069 137.920 1.00 73.87  ? 323 SER A OG  1 
ATOM   2008 N N   . SER A 1 324 ? 173.399 169.100 138.557 1.00 74.23  ? 324 SER A N   1 
ATOM   2009 C CA  . SER A 1 324 ? 174.593 169.705 139.132 1.00 74.23  ? 324 SER A CA  1 
ATOM   2010 C C   . SER A 1 324 ? 174.304 171.032 139.820 1.00 74.23  ? 324 SER A C   1 
ATOM   2011 O O   . SER A 1 324 ? 174.919 171.335 140.848 1.00 74.23  ? 324 SER A O   1 
ATOM   2012 C CB  . SER A 1 324 ? 175.651 169.923 138.050 1.00 74.23  ? 324 SER A CB  1 
ATOM   2013 O OG  . SER A 1 324 ? 175.463 171.174 137.412 1.00 74.23  ? 324 SER A OG  1 
ATOM   2014 N N   . LEU A 1 325 ? 173.388 171.832 139.270 1.00 75.72  ? 325 LEU A N   1 
ATOM   2015 C CA  . LEU A 1 325 ? 173.117 173.151 139.832 1.00 75.72  ? 325 LEU A CA  1 
ATOM   2016 C C   . LEU A 1 325 ? 172.111 173.097 140.974 1.00 75.72  ? 325 LEU A C   1 
ATOM   2017 O O   . LEU A 1 325 ? 171.960 174.086 141.699 1.00 75.72  ? 325 LEU A O   1 
ATOM   2018 C CB  . LEU A 1 325 ? 172.616 174.096 138.741 1.00 75.72  ? 325 LEU A CB  1 
ATOM   2019 C CG  . LEU A 1 325 ? 173.642 174.558 137.708 1.00 75.72  ? 325 LEU A CG  1 
ATOM   2020 C CD1 . LEU A 1 325 ? 172.965 175.368 136.617 1.00 75.72  ? 325 LEU A CD1 1 
ATOM   2021 C CD2 . LEU A 1 325 ? 174.740 175.368 138.375 1.00 75.72  ? 325 LEU A CD2 1 
ATOM   2022 N N   . ASN A 1 326 ? 171.401 171.979 141.134 1.00 76.18  ? 326 ASN A N   1 
ATOM   2023 C CA  . ASN A 1 326 ? 170.458 171.865 142.247 1.00 76.18  ? 326 ASN A CA  1 
ATOM   2024 C C   . ASN A 1 326 ? 171.088 171.983 143.637 1.00 76.18  ? 326 ASN A C   1 
ATOM   2025 O O   . ASN A 1 326 ? 170.515 172.714 144.465 1.00 76.18  ? 326 ASN A O   1 
ATOM   2026 C CB  . ASN A 1 326 ? 169.648 170.565 142.123 1.00 76.18  ? 326 ASN A CB  1 
ATOM   2027 C CG  . ASN A 1 326 ? 168.492 170.688 141.154 1.00 76.18  ? 326 ASN A CG  1 
ATOM   2028 O OD1 . ASN A 1 326 ? 168.309 171.724 140.515 1.00 76.18  ? 326 ASN A OD1 1 
ATOM   2029 N ND2 . ASN A 1 326 ? 167.701 169.629 141.040 1.00 76.18  ? 326 ASN A ND2 1 
ATOM   2030 N N   . PRO A 1 327 ? 172.209 171.318 143.981 1.00 82.12  ? 327 PRO A N   1 
ATOM   2031 C CA  . PRO A 1 327 ? 172.767 171.539 145.331 1.00 82.12  ? 327 PRO A CA  1 
ATOM   2032 C C   . PRO A 1 327 ? 173.261 172.957 145.572 1.00 82.12  ? 327 PRO A C   1 
ATOM   2033 O O   . PRO A 1 327 ? 173.060 173.496 146.666 1.00 82.12  ? 327 PRO A O   1 
ATOM   2034 C CB  . PRO A 1 327 ? 173.908 170.513 145.411 1.00 82.12  ? 327 PRO A CB  1 
ATOM   2035 C CG  . PRO A 1 327 ? 173.564 169.482 144.422 1.00 82.12  ? 327 PRO A CG  1 
ATOM   2036 C CD  . PRO A 1 327 ? 172.950 170.240 143.296 1.00 82.12  ? 327 PRO A CD  1 
ATOM   2037 N N   . ILE A 1 328 ? 173.882 173.586 144.571 1.00 82.66  ? 328 ILE A N   1 
ATOM   2038 C CA  . ILE A 1 328 ? 174.386 174.947 144.744 1.00 82.66  ? 328 ILE A CA  1 
ATOM   2039 C C   . ILE A 1 328 ? 173.235 175.931 144.922 1.00 82.66  ? 328 ILE A C   1 
ATOM   2040 O O   . ILE A 1 328 ? 173.276 176.806 145.799 1.00 82.66  ? 328 ILE A O   1 
ATOM   2041 C CB  . ILE A 1 328 ? 175.284 175.338 143.557 1.00 82.66  ? 328 ILE A CB  1 
ATOM   2042 N N   . LEU A 1 329 ? 172.192 175.800 144.096 1.00 82.20  ? 329 LEU A N   1 
ATOM   2043 C CA  . LEU A 1 329 ? 171.023 176.664 144.216 1.00 82.20  ? 329 LEU A CA  1 
ATOM   2044 C C   . LEU A 1 329 ? 170.305 176.444 145.542 1.00 82.20  ? 329 LEU A C   1 
ATOM   2045 O O   . LEU A 1 329 ? 169.949 177.409 146.227 1.00 82.20  ? 329 LEU A O   1 
ATOM   2046 C CB  . LEU A 1 329 ? 170.080 176.421 143.035 1.00 82.20  ? 329 LEU A CB  1 
ATOM   2047 C CG  . LEU A 1 329 ? 168.860 177.317 142.803 1.00 82.20  ? 329 LEU A CG  1 
ATOM   2048 C CD1 . LEU A 1 329 ? 168.671 177.537 141.314 1.00 82.20  ? 329 LEU A CD1 1 
ATOM   2049 C CD2 . LEU A 1 329 ? 167.600 176.706 143.397 1.00 82.20  ? 329 LEU A CD2 1 
ATOM   2050 N N   . TYR A 1 330 ? 170.112 175.189 145.938 1.00 79.63  ? 330 TYR A N   1 
ATOM   2051 C CA  . TYR A 1 330 ? 169.412 174.892 147.180 1.00 79.63  ? 330 TYR A CA  1 
ATOM   2052 C C   . TYR A 1 330 ? 170.273 175.110 148.418 1.00 79.63  ? 330 TYR A C   1 
ATOM   2053 O O   . TYR A 1 330 ? 169.755 175.010 149.535 1.00 79.63  ? 330 TYR A O   1 
ATOM   2054 C CB  . TYR A 1 330 ? 168.887 173.457 147.150 1.00 79.63  ? 330 TYR A CB  1 
ATOM   2055 C CG  . TYR A 1 330 ? 167.563 173.320 146.436 1.00 79.63  ? 330 TYR A CG  1 
ATOM   2056 C CD1 . TYR A 1 330 ? 166.429 173.964 146.911 1.00 79.63  ? 330 TYR A CD1 1 
ATOM   2057 C CD2 . TYR A 1 330 ? 167.447 172.549 145.287 1.00 79.63  ? 330 TYR A CD2 1 
ATOM   2058 C CE1 . TYR A 1 330 ? 165.215 173.844 146.262 1.00 79.63  ? 330 TYR A CE1 1 
ATOM   2059 C CE2 . TYR A 1 330 ? 166.238 172.422 144.630 1.00 79.63  ? 330 TYR A CE2 1 
ATOM   2060 C CZ  . TYR A 1 330 ? 165.126 173.071 145.122 1.00 79.63  ? 330 TYR A CZ  1 
ATOM   2061 O OH  . TYR A 1 330 ? 163.919 172.947 144.472 1.00 79.63  ? 330 TYR A OH  1 
ATOM   2062 N N   . ALA A 1 331 ? 171.565 175.382 148.254 1.00 83.80  ? 331 ALA A N   1 
ATOM   2063 C CA  . ALA A 1 331 ? 172.413 175.793 149.364 1.00 83.80  ? 331 ALA A CA  1 
ATOM   2064 C C   . ALA A 1 331 ? 172.531 177.304 149.488 1.00 83.80  ? 331 ALA A C   1 
ATOM   2065 O O   . ALA A 1 331 ? 172.619 177.822 150.606 1.00 83.80  ? 331 ALA A O   1 
ATOM   2066 C CB  . ALA A 1 331 ? 173.811 175.183 149.217 1.00 83.80  ? 331 ALA A CB  1 
ATOM   2067 N N   . PHE A 1 332 ? 172.539 178.028 148.370 1.00 84.17  ? 332 PHE A N   1 
ATOM   2068 C CA  . PHE A 1 332 ? 172.649 179.480 148.396 1.00 84.17  ? 332 PHE A CA  1 
ATOM   2069 C C   . PHE A 1 332 ? 171.306 180.190 148.272 1.00 84.17  ? 332 PHE A C   1 
ATOM   2070 O O   . PHE A 1 332 ? 171.281 181.422 148.192 1.00 84.17  ? 332 PHE A O   1 
ATOM   2071 C CB  . PHE A 1 332 ? 173.588 179.956 147.282 1.00 84.17  ? 332 PHE A CB  1 
ATOM   2072 N N   . LEU A 1 333 ? 170.192 179.451 148.255 1.00 85.61  ? 333 LEU A N   1 
ATOM   2073 C CA  . LEU A 1 333 ? 168.890 180.070 148.047 1.00 85.61  ? 333 LEU A CA  1 
ATOM   2074 C C   . LEU A 1 333 ? 167.833 179.662 149.072 1.00 85.61  ? 333 LEU A C   1 
ATOM   2075 O O   . LEU A 1 333 ? 166.870 180.412 149.273 1.00 85.61  ? 333 LEU A O   1 
ATOM   2076 C CB  . LEU A 1 333 ? 168.418 179.737 146.620 1.00 85.61  ? 333 LEU A CB  1 
ATOM   2077 C CG  . LEU A 1 333 ? 167.083 180.204 146.047 1.00 85.61  ? 333 LEU A CG  1 
ATOM   2078 C CD1 . LEU A 1 333 ? 167.242 180.732 144.638 1.00 85.61  ? 333 LEU A CD1 1 
ATOM   2079 C CD2 . LEU A 1 333 ? 166.165 179.002 146.040 1.00 85.61  ? 333 LEU A CD2 1 
ATOM   2080 N N   . ASP A 1 334 ? 167.990 178.528 149.752 1.00 86.85  ? 334 ASP A N   1 
ATOM   2081 C CA  . ASP A 1 334 ? 166.957 178.023 150.647 1.00 86.85  ? 334 ASP A CA  1 
ATOM   2082 C C   . ASP A 1 334 ? 166.885 178.795 151.962 1.00 86.85  ? 334 ASP A C   1 
ATOM   2083 O O   . ASP A 1 334 ? 165.913 178.631 152.707 1.00 86.85  ? 334 ASP A O   1 
ATOM   2084 C CB  . ASP A 1 334 ? 167.197 176.528 150.918 1.00 86.85  ? 334 ASP A CB  1 
ATOM   2085 C CG  . ASP A 1 334 ? 166.039 175.858 151.640 1.00 86.85  ? 334 ASP A CG  1 
ATOM   2086 O OD1 . ASP A 1 334 ? 164.999 175.607 150.996 1.00 86.85  ? 334 ASP A OD1 1 
ATOM   2087 O OD2 . ASP A 1 334 ? 166.173 175.588 152.852 1.00 86.85  ? 334 ASP A OD2 1 
ATOM   2088 N N   . GLU A 1 335 ? 167.918 179.580 152.282 1.00 88.40  ? 335 GLU A N   1 
ATOM   2089 C CA  . GLU A 1 335 ? 167.977 180.562 153.369 1.00 88.40  ? 335 GLU A CA  1 
ATOM   2090 C C   . GLU A 1 335 ? 168.022 179.942 154.764 1.00 88.40  ? 335 GLU A C   1 
ATOM   2091 O O   . GLU A 1 335 ? 168.363 180.631 155.730 1.00 88.40  ? 335 GLU A O   1 
ATOM   2092 C CB  . GLU A 1 335 ? 166.810 181.556 153.286 1.00 88.40  ? 335 GLU A CB  1 
ATOM   2093 C CG  . GLU A 1 335 ? 166.883 182.510 152.108 1.00 88.40  ? 335 GLU A CG  1 
ATOM   2094 C CD  . GLU A 1 335 ? 168.019 183.506 152.239 1.00 88.40  ? 335 GLU A CD  1 
ATOM   2095 O OE1 . GLU A 1 335 ? 168.339 183.898 153.382 1.00 88.40  ? 335 GLU A OE1 1 
ATOM   2096 O OE2 . GLU A 1 335 ? 168.592 183.899 151.201 1.00 88.40  ? 335 GLU A OE2 1 
ATOM   2097 N N   . ASN A 1 336 ? 167.772 178.640 154.883 1.00 88.94  ? 336 ASN A N   1 
ATOM   2098 C CA  . ASN A 1 336 ? 168.056 177.962 156.139 1.00 88.94  ? 336 ASN A CA  1 
ATOM   2099 C C   . ASN A 1 336 ? 169.540 177.648 156.232 1.00 88.94  ? 336 ASN A C   1 
ATOM   2100 O O   . ASN A 1 336 ? 170.158 177.826 157.286 1.00 88.94  ? 336 ASN A O   1 
ATOM   2101 C CB  . ASN A 1 336 ? 167.222 176.683 156.266 1.00 88.94  ? 336 ASN A CB  1 
ATOM   2102 C CG  . ASN A 1 336 ? 165.757 176.965 156.530 1.00 88.94  ? 336 ASN A CG  1 
ATOM   2103 O OD1 . ASN A 1 336 ? 165.415 177.849 157.315 1.00 88.94  ? 336 ASN A OD1 1 
ATOM   2104 N ND2 . ASN A 1 336 ? 164.882 176.208 155.879 1.00 88.94  ? 336 ASN A ND2 1 
ATOM   2105 N N   . PHE A 1 337 ? 170.125 177.216 155.114 1.00 89.81  ? 337 PHE A N   1 
ATOM   2106 C CA  . PHE A 1 337 ? 171.573 177.084 155.031 1.00 89.81  ? 337 PHE A CA  1 
ATOM   2107 C C   . PHE A 1 337 ? 172.257 178.442 155.118 1.00 89.81  ? 337 PHE A C   1 
ATOM   2108 O O   . PHE A 1 337 ? 173.365 178.540 155.654 1.00 89.81  ? 337 PHE A O   1 
ATOM   2109 C CB  . PHE A 1 337 ? 171.960 176.368 153.735 1.00 89.81  ? 337 PHE A CB  1 
ATOM   2110 C CG  . PHE A 1 337 ? 171.720 174.879 153.759 1.00 89.81  ? 337 PHE A CG  1 
ATOM   2111 C CD1 . PHE A 1 337 ? 171.231 174.247 154.894 1.00 89.81  ? 337 PHE A CD1 1 
ATOM   2112 C CD2 . PHE A 1 337 ? 171.984 174.111 152.636 1.00 89.81  ? 337 PHE A CD2 1 
ATOM   2113 C CE1 . PHE A 1 337 ? 171.014 172.882 154.909 1.00 89.81  ? 337 PHE A CE1 1 
ATOM   2114 C CE2 . PHE A 1 337 ? 171.769 172.744 152.645 1.00 89.81  ? 337 PHE A CE2 1 
ATOM   2115 C CZ  . PHE A 1 337 ? 171.283 172.130 153.783 1.00 89.81  ? 337 PHE A CZ  1 
ATOM   2116 N N   . LYS A 1 338 ? 171.618 179.493 154.597 1.00 92.01  ? 338 LYS A N   1 
ATOM   2117 C CA  . LYS A 1 338 ? 172.158 180.841 154.746 1.00 92.01  ? 338 LYS A CA  1 
ATOM   2118 C C   . LYS A 1 338 ? 172.097 181.305 156.197 1.00 92.01  ? 338 LYS A C   1 
ATOM   2119 O O   . LYS A 1 338 ? 173.021 181.970 156.681 1.00 92.01  ? 338 LYS A O   1 
ATOM   2120 C CB  . LYS A 1 338 ? 171.404 181.813 153.838 1.00 92.01  ? 338 LYS A CB  1 
ATOM   2121 C CG  . LYS A 1 338 ? 171.951 183.232 153.836 1.00 92.01  ? 338 LYS A CG  1 
ATOM   2122 C CD  . LYS A 1 338 ? 173.300 183.303 153.138 1.00 92.01  ? 338 LYS A CD  1 
ATOM   2123 C CE  . LYS A 1 338 ? 173.760 184.742 152.960 1.00 92.01  ? 338 LYS A CE  1 
ATOM   2124 N NZ  . LYS A 1 338 ? 174.062 185.398 154.261 1.00 92.01  ? 338 LYS A NZ  1 
ATOM   2125 N N   . ARG A 1 339 ? 171.011 180.974 156.904 1.00 93.04  ? 339 ARG A N   1 
ATOM   2126 C CA  . ARG A 1 339 ? 170.910 181.323 158.318 1.00 93.04  ? 339 ARG A CA  1 
ATOM   2127 C C   . ARG A 1 339 ? 171.921 180.549 159.156 1.00 93.04  ? 339 ARG A C   1 
ATOM   2128 O O   . ARG A 1 339 ? 172.498 181.097 160.103 1.00 93.04  ? 339 ARG A O   1 
ATOM   2129 C CB  . ARG A 1 339 ? 169.489 181.067 158.820 1.00 93.04  ? 339 ARG A CB  1 
ATOM   2130 N N   . CYS A 1 340 ? 172.147 179.276 158.825 1.00 95.29  ? 340 CYS A N   1 
ATOM   2131 C CA  . CYS A 1 340 ? 173.085 178.467 159.598 1.00 95.29  ? 340 CYS A CA  1 
ATOM   2132 C C   . CYS A 1 340 ? 174.531 178.855 159.311 1.00 95.29  ? 340 CYS A C   1 
ATOM   2133 O O   . CYS A 1 340 ? 175.353 178.926 160.231 1.00 95.29  ? 340 CYS A O   1 
ATOM   2134 C CB  . CYS A 1 340 ? 172.860 176.984 159.306 1.00 95.29  ? 340 CYS A CB  1 
ATOM   2135 S SG  . CYS A 1 340 ? 173.917 175.870 160.256 1.00 95.29  ? 340 CYS A SG  1 
ATOM   2136 N N   . PHE A 1 341 ? 174.862 179.104 158.042 1.00 96.35  ? 341 PHE A N   1 
ATOM   2137 C CA  . PHE A 1 341 ? 176.235 179.445 157.685 1.00 96.35  ? 341 PHE A CA  1 
ATOM   2138 C C   . PHE A 1 341 ? 176.583 180.868 158.102 1.00 96.35  ? 341 PHE A C   1 
ATOM   2139 O O   . PHE A 1 341 ? 177.707 181.127 158.549 1.00 96.35  ? 341 PHE A O   1 
ATOM   2140 C CB  . PHE A 1 341 ? 176.447 179.260 156.182 1.00 96.35  ? 341 PHE A CB  1 
ATOM   2141 N N   . ARG A 1 342 ? 175.631 181.792 157.957 1.00 95.32  ? 342 ARG A N   1 
ATOM   2142 C CA  . ARG A 1 342 ? 175.784 183.217 158.279 1.00 95.32  ? 342 ARG A CA  1 
ATOM   2143 C C   . ARG A 1 342 ? 176.970 183.865 157.565 1.00 95.32  ? 342 ARG A C   1 
ATOM   2144 O O   . ARG A 1 342 ? 178.048 184.015 158.141 1.00 95.32  ? 342 ARG A O   1 
ATOM   2145 C CB  . ARG A 1 342 ? 175.910 183.421 159.794 1.00 95.32  ? 342 ARG A CB  1 
ATOM   2146 N N   . SER B 2 2   ? 159.192 217.173 210.537 1.00 229.50 ? 2   SER C N   1 
ATOM   2147 C CA  . SER B 2 2   ? 160.648 217.212 210.612 1.00 229.50 ? 2   SER C CA  1 
ATOM   2148 C C   . SER B 2 2   ? 161.196 215.930 211.229 1.00 229.50 ? 2   SER C C   1 
ATOM   2149 O O   . SER B 2 2   ? 162.401 215.677 211.185 1.00 229.50 ? 2   SER C O   1 
ATOM   2150 C CB  . SER B 2 2   ? 161.112 218.424 211.421 1.00 229.50 ? 2   SER C CB  1 
ATOM   2151 O OG  . SER B 2 2   ? 160.670 218.340 212.764 1.00 229.50 ? 2   SER C OG  1 
ATOM   2152 N N   . GLU B 2 3   ? 160.300 215.132 211.817 1.00 228.36 ? 3   GLU C N   1 
ATOM   2153 C CA  . GLU B 2 3   ? 160.711 213.862 212.408 1.00 228.36 ? 3   GLU C CA  1 
ATOM   2154 C C   . GLU B 2 3   ? 161.172 212.878 211.340 1.00 228.36 ? 3   GLU C C   1 
ATOM   2155 O O   . GLU B 2 3   ? 162.156 212.155 211.540 1.00 228.36 ? 3   GLU C O   1 
ATOM   2156 C CB  . GLU B 2 3   ? 159.564 213.272 213.228 1.00 228.36 ? 3   GLU C CB  1 
ATOM   2157 C CG  . GLU B 2 3   ? 159.915 211.983 213.954 1.00 228.36 ? 3   GLU C CG  1 
ATOM   2158 C CD  . GLU B 2 3   ? 160.806 212.217 215.158 1.00 228.36 ? 3   GLU C CD  1 
ATOM   2159 O OE1 . GLU B 2 3   ? 160.738 213.317 215.746 1.00 228.36 ? 3   GLU C OE1 1 
ATOM   2160 O OE2 . GLU B 2 3   ? 161.575 211.300 215.517 1.00 228.36 ? 3   GLU C OE2 1 
ATOM   2161 N N   . LEU B 2 4   ? 160.472 212.836 210.203 1.00 224.21 ? 4   LEU C N   1 
ATOM   2162 C CA  . LEU B 2 4   ? 160.882 211.969 209.101 1.00 224.21 ? 4   LEU C CA  1 
ATOM   2163 C C   . LEU B 2 4   ? 162.226 212.400 208.527 1.00 224.21 ? 4   LEU C C   1 
ATOM   2164 O O   . LEU B 2 4   ? 163.074 211.555 208.217 1.00 224.21 ? 4   LEU C O   1 
ATOM   2165 C CB  . LEU B 2 4   ? 159.811 211.966 208.011 1.00 224.21 ? 4   LEU C CB  1 
ATOM   2166 C CG  . LEU B 2 4   ? 159.956 210.907 206.918 1.00 224.21 ? 4   LEU C CG  1 
ATOM   2167 C CD1 . LEU B 2 4   ? 159.667 209.526 207.476 1.00 224.21 ? 4   LEU C CD1 1 
ATOM   2168 C CD2 . LEU B 2 4   ? 159.041 211.216 205.745 1.00 224.21 ? 4   LEU C CD2 1 
ATOM   2169 N N   . ASP B 2 5   ? 162.438 213.712 208.385 1.00 221.02 ? 5   ASP C N   1 
ATOM   2170 C CA  . ASP B 2 5   ? 163.721 214.216 207.904 1.00 221.02 ? 5   ASP C CA  1 
ATOM   2171 C C   . ASP B 2 5   ? 164.840 213.920 208.895 1.00 221.02 ? 5   ASP C C   1 
ATOM   2172 O O   . ASP B 2 5   ? 165.959 213.580 208.491 1.00 221.02 ? 5   ASP C O   1 
ATOM   2173 C CB  . ASP B 2 5   ? 163.626 215.717 207.633 1.00 221.02 ? 5   ASP C CB  1 
ATOM   2174 N N   . GLN B 2 6   ? 164.556 214.044 210.195 1.00 219.92 ? 6   GLN C N   1 
ATOM   2175 C CA  . GLN B 2 6   ? 165.550 213.719 211.214 1.00 219.92 ? 6   GLN C CA  1 
ATOM   2176 C C   . GLN B 2 6   ? 165.905 212.237 211.189 1.00 219.92 ? 6   GLN C C   1 
ATOM   2177 O O   . GLN B 2 6   ? 167.080 211.871 211.317 1.00 219.92 ? 6   GLN C O   1 
ATOM   2178 C CB  . GLN B 2 6   ? 165.033 214.120 212.596 1.00 219.92 ? 6   GLN C CB  1 
ATOM   2179 C CG  . GLN B 2 6   ? 166.028 213.899 213.722 1.00 219.92 ? 6   GLN C CG  1 
ATOM   2180 C CD  . GLN B 2 6   ? 165.492 214.345 215.066 1.00 219.92 ? 6   GLN C CD  1 
ATOM   2181 O OE1 . GLN B 2 6   ? 164.350 214.790 215.175 1.00 219.92 ? 6   GLN C OE1 1 
ATOM   2182 N NE2 . GLN B 2 6   ? 166.317 214.229 216.101 1.00 219.92 ? 6   GLN C NE2 1 
ATOM   2183 N N   . LEU B 2 7   ? 164.901 211.371 211.021 1.00 215.30 ? 7   LEU C N   1 
ATOM   2184 C CA  . LEU B 2 7   ? 165.155 209.937 210.927 1.00 215.30 ? 7   LEU C CA  1 
ATOM   2185 C C   . LEU B 2 7   ? 165.953 209.594 209.676 1.00 215.30 ? 7   LEU C C   1 
ATOM   2186 O O   . LEU B 2 7   ? 166.848 208.740 209.719 1.00 215.30 ? 7   LEU C O   1 
ATOM   2187 C CB  . LEU B 2 7   ? 163.834 209.171 210.946 1.00 215.30 ? 7   LEU C CB  1 
ATOM   2188 C CG  . LEU B 2 7   ? 163.128 209.065 212.299 1.00 215.30 ? 7   LEU C CG  1 
ATOM   2189 C CD1 . LEU B 2 7   ? 161.864 208.234 212.171 1.00 215.30 ? 7   LEU C CD1 1 
ATOM   2190 C CD2 . LEU B 2 7   ? 164.056 208.477 213.350 1.00 215.30 ? 7   LEU C CD2 1 
ATOM   2191 N N   . ARG B 2 8   ? 165.644 210.251 208.553 1.00 210.16 ? 8   ARG C N   1 
ATOM   2192 C CA  . ARG B 2 8   ? 166.400 210.028 207.324 1.00 210.16 ? 8   ARG C CA  1 
ATOM   2193 C C   . ARG B 2 8   ? 167.848 210.478 207.474 1.00 210.16 ? 8   ARG C C   1 
ATOM   2194 O O   . ARG B 2 8   ? 168.768 209.790 207.018 1.00 210.16 ? 8   ARG C O   1 
ATOM   2195 C CB  . ARG B 2 8   ? 165.730 210.754 206.158 1.00 210.16 ? 8   ARG C CB  1 
ATOM   2196 N N   . GLN B 2 9   ? 168.068 211.625 208.124 1.00 207.44 ? 9   GLN C N   1 
ATOM   2197 C CA  . GLN B 2 9   ? 169.428 212.103 208.357 1.00 207.44 ? 9   GLN C CA  1 
ATOM   2198 C C   . GLN B 2 9   ? 170.191 211.177 209.296 1.00 207.44 ? 9   GLN C C   1 
ATOM   2199 O O   . GLN B 2 9   ? 171.385 210.925 209.090 1.00 207.44 ? 9   GLN C O   1 
ATOM   2200 C CB  . GLN B 2 9   ? 169.395 213.523 208.919 1.00 207.44 ? 9   GLN C CB  1 
ATOM   2201 C CG  . GLN B 2 9   ? 169.283 214.607 207.862 1.00 207.44 ? 9   GLN C CG  1 
ATOM   2202 C CD  . GLN B 2 9   ? 169.368 216.001 208.451 1.00 207.44 ? 9   GLN C CD  1 
ATOM   2203 O OE1 . GLN B 2 9   ? 169.541 216.168 209.658 1.00 207.44 ? 9   GLN C OE1 1 
ATOM   2204 N NE2 . GLN B 2 9   ? 169.247 217.012 207.598 1.00 207.44 ? 9   GLN C NE2 1 
ATOM   2205 N N   . GLU B 2 10  ? 169.520 210.665 210.333 1.00 202.31 ? 10  GLU C N   1 
ATOM   2206 C CA  . GLU B 2 10  ? 170.161 209.731 211.253 1.00 202.31 ? 10  GLU C CA  1 
ATOM   2207 C C   . GLU B 2 10  ? 170.534 208.430 210.553 1.00 202.31 ? 10  GLU C C   1 
ATOM   2208 O O   . GLU B 2 10  ? 171.633 207.899 210.759 1.00 202.31 ? 10  GLU C O   1 
ATOM   2209 C CB  . GLU B 2 10  ? 169.243 209.456 212.442 1.00 202.31 ? 10  GLU C CB  1 
ATOM   2210 C CG  . GLU B 2 10  ? 169.973 208.997 213.692 1.00 202.31 ? 10  GLU C CG  1 
ATOM   2211 C CD  . GLU B 2 10  ? 169.074 208.962 214.911 1.00 202.31 ? 10  GLU C CD  1 
ATOM   2212 O OE1 . GLU B 2 10  ? 167.854 209.182 214.759 1.00 202.31 ? 10  GLU C OE1 1 
ATOM   2213 O OE2 . GLU B 2 10  ? 169.587 208.714 216.023 1.00 202.31 ? 10  GLU C OE2 1 
ATOM   2214 N N   . ALA B 2 11  ? 169.635 207.911 209.711 1.00 195.85 ? 11  ALA C N   1 
ATOM   2215 C CA  . ALA B 2 11  ? 169.936 206.702 208.952 1.00 195.85 ? 11  ALA C CA  1 
ATOM   2216 C C   . ALA B 2 11  ? 171.079 206.935 207.973 1.00 195.85 ? 11  ALA C C   1 
ATOM   2217 O O   . ALA B 2 11  ? 171.948 206.071 207.807 1.00 195.85 ? 11  ALA C O   1 
ATOM   2218 C CB  . ALA B 2 11  ? 168.687 206.219 208.215 1.00 195.85 ? 11  ALA C CB  1 
ATOM   2219 N N   . GLU B 2 12  ? 171.105 208.109 207.334 1.00 191.59 ? 12  GLU C N   1 
ATOM   2220 C CA  . GLU B 2 12  ? 172.176 208.433 206.398 1.00 191.59 ? 12  GLU C CA  1 
ATOM   2221 C C   . GLU B 2 12  ? 173.527 208.524 207.100 1.00 191.59 ? 12  GLU C C   1 
ATOM   2222 O O   . GLU B 2 12  ? 174.517 207.953 206.626 1.00 191.59 ? 12  GLU C O   1 
ATOM   2223 C CB  . GLU B 2 12  ? 171.855 209.743 205.680 1.00 191.59 ? 12  GLU C CB  1 
ATOM   2224 C CG  . GLU B 2 12  ? 173.000 210.307 204.857 1.00 191.59 ? 12  GLU C CG  1 
ATOM   2225 C CD  . GLU B 2 12  ? 172.783 211.760 204.485 1.00 191.59 ? 12  GLU C CD  1 
ATOM   2226 O OE1 . GLU B 2 12  ? 171.614 212.159 204.307 1.00 191.59 ? 12  GLU C OE1 1 
ATOM   2227 O OE2 . GLU B 2 12  ? 173.781 212.503 204.375 1.00 191.59 ? 12  GLU C OE2 1 
ATOM   2228 N N   . GLN B 2 13  ? 173.586 209.213 208.244 1.00 187.90 ? 13  GLN C N   1 
ATOM   2229 C CA  . GLN B 2 13  ? 174.866 209.351 208.934 1.00 187.90 ? 13  GLN C CA  1 
ATOM   2230 C C   . GLN B 2 13  ? 175.310 208.036 209.565 1.00 187.90 ? 13  GLN C C   1 
ATOM   2231 O O   . GLN B 2 13  ? 176.513 207.759 209.626 1.00 187.90 ? 13  GLN C O   1 
ATOM   2232 C CB  . GLN B 2 13  ? 174.802 210.477 209.975 1.00 187.90 ? 13  GLN C CB  1 
ATOM   2233 C CG  . GLN B 2 13  ? 173.851 210.265 211.146 1.00 187.90 ? 13  GLN C CG  1 
ATOM   2234 C CD  . GLN B 2 13  ? 174.519 209.606 212.338 1.00 187.90 ? 13  GLN C CD  1 
ATOM   2235 O OE1 . GLN B 2 13  ? 175.718 209.773 212.562 1.00 187.90 ? 13  GLN C OE1 1 
ATOM   2236 N NE2 . GLN B 2 13  ? 173.745 208.850 213.107 1.00 187.90 ? 13  GLN C NE2 1 
ATOM   2237 N N   . LEU B 2 14  ? 174.369 207.192 210.000 1.00 181.15 ? 14  LEU C N   1 
ATOM   2238 C CA  . LEU B 2 14  ? 174.765 205.897 210.540 1.00 181.15 ? 14  LEU C CA  1 
ATOM   2239 C C   . LEU B 2 14  ? 175.234 204.947 209.444 1.00 181.15 ? 14  LEU C C   1 
ATOM   2240 O O   . LEU B 2 14  ? 176.176 204.175 209.658 1.00 181.15 ? 14  LEU C O   1 
ATOM   2241 C CB  . LEU B 2 14  ? 173.616 205.283 211.330 1.00 181.15 ? 14  LEU C CB  1 
ATOM   2242 C CG  . LEU B 2 14  ? 174.024 204.088 212.188 1.00 181.15 ? 14  LEU C CG  1 
ATOM   2243 C CD1 . LEU B 2 14  ? 175.117 204.474 213.170 1.00 181.15 ? 14  LEU C CD1 1 
ATOM   2244 C CD2 . LEU B 2 14  ? 172.814 203.561 212.918 1.00 181.15 ? 14  LEU C CD2 1 
ATOM   2245 N N   . LYS B 2 15  ? 174.608 204.996 208.264 1.00 173.07 ? 15  LYS C N   1 
ATOM   2246 C CA  . LYS B 2 15  ? 175.113 204.220 207.136 1.00 173.07 ? 15  LYS C CA  1 
ATOM   2247 C C   . LYS B 2 15  ? 176.476 204.732 206.687 1.00 173.07 ? 15  LYS C C   1 
ATOM   2248 O O   . LYS B 2 15  ? 177.329 203.947 206.258 1.00 173.07 ? 15  LYS C O   1 
ATOM   2249 C CB  . LYS B 2 15  ? 174.113 204.256 205.982 1.00 173.07 ? 15  LYS C CB  1 
ATOM   2250 N N   . ASN B 2 16  ? 176.699 206.045 206.788 1.00 170.91 ? 16  ASN C N   1 
ATOM   2251 C CA  . ASN B 2 16  ? 178.023 206.599 206.517 1.00 170.91 ? 16  ASN C CA  1 
ATOM   2252 C C   . ASN B 2 16  ? 179.045 206.106 207.533 1.00 170.91 ? 16  ASN C C   1 
ATOM   2253 O O   . ASN B 2 16  ? 180.202 205.848 207.185 1.00 170.91 ? 16  ASN C O   1 
ATOM   2254 C CB  . ASN B 2 16  ? 177.962 208.126 206.518 1.00 170.91 ? 16  ASN C CB  1 
ATOM   2255 C CG  . ASN B 2 16  ? 177.272 208.681 205.291 1.00 170.91 ? 16  ASN C CG  1 
ATOM   2256 O OD1 . ASN B 2 16  ? 176.764 207.931 204.458 1.00 170.91 ? 16  ASN C OD1 1 
ATOM   2257 N ND2 . ASN B 2 16  ? 177.249 210.003 205.172 1.00 170.91 ? 16  ASN C ND2 1 
ATOM   2258 N N   . GLN B 2 17  ? 178.635 205.981 208.798 1.00 167.17 ? 17  GLN C N   1 
ATOM   2259 C CA  . GLN B 2 17  ? 179.513 205.415 209.819 1.00 167.17 ? 17  GLN C CA  1 
ATOM   2260 C C   . GLN B 2 17  ? 179.842 203.956 209.520 1.00 167.17 ? 17  GLN C C   1 
ATOM   2261 O O   . GLN B 2 17  ? 180.981 203.517 209.712 1.00 167.17 ? 17  GLN C O   1 
ATOM   2262 C CB  . GLN B 2 17  ? 178.867 205.549 211.198 1.00 167.17 ? 17  GLN C CB  1 
ATOM   2263 C CG  . GLN B 2 17  ? 179.788 205.203 212.357 1.00 167.17 ? 17  GLN C CG  1 
ATOM   2264 C CD  . GLN B 2 17  ? 179.560 203.800 212.885 1.00 167.17 ? 17  GLN C CD  1 
ATOM   2265 O OE1 . GLN B 2 17  ? 178.449 203.274 212.820 1.00 167.17 ? 17  GLN C OE1 1 
ATOM   2266 N NE2 . GLN B 2 17  ? 180.613 203.187 213.412 1.00 167.17 ? 17  GLN C NE2 1 
ATOM   2267 N N   . ILE B 2 18  ? 178.850 203.194 209.049 1.00 158.57 ? 18  ILE C N   1 
ATOM   2268 C CA  . ILE B 2 18  ? 179.079 201.804 208.648 1.00 158.57 ? 18  ILE C CA  1 
ATOM   2269 C C   . ILE B 2 18  ? 180.062 201.736 207.483 1.00 158.57 ? 18  ILE C C   1 
ATOM   2270 O O   . ILE B 2 18  ? 180.977 200.899 207.465 1.00 158.57 ? 18  ILE C O   1 
ATOM   2271 C CB  . ILE B 2 18  ? 177.739 201.127 208.301 1.00 158.57 ? 18  ILE C CB  1 
ATOM   2272 C CG1 . ILE B 2 18  ? 176.876 200.971 209.552 1.00 158.57 ? 18  ILE C CG1 1 
ATOM   2273 C CG2 . ILE B 2 18  ? 177.955 199.773 207.640 1.00 158.57 ? 18  ILE C CG2 1 
ATOM   2274 C CD1 . ILE B 2 18  ? 175.482 200.481 209.261 1.00 158.57 ? 18  ILE C CD1 1 
ATOM   2275 N N   . ARG B 2 19  ? 179.887 202.620 206.496 1.00 155.24 ? 19  ARG C N   1 
ATOM   2276 C CA  . ARG B 2 19  ? 180.784 202.659 205.346 1.00 155.24 ? 19  ARG C CA  1 
ATOM   2277 C C   . ARG B 2 19  ? 182.202 203.032 205.758 1.00 155.24 ? 19  ARG C C   1 
ATOM   2278 O O   . ARG B 2 19  ? 183.172 202.448 205.263 1.00 155.24 ? 19  ARG C O   1 
ATOM   2279 C CB  . ARG B 2 19  ? 180.255 203.644 204.305 1.00 155.24 ? 19  ARG C CB  1 
ATOM   2280 C CG  . ARG B 2 19  ? 179.050 203.140 203.532 1.00 155.24 ? 19  ARG C CG  1 
ATOM   2281 C CD  . ARG B 2 19  ? 178.757 204.026 202.335 1.00 155.24 ? 19  ARG C CD  1 
ATOM   2282 N NE  . ARG B 2 19  ? 178.498 205.406 202.728 1.00 155.24 ? 19  ARG C NE  1 
ATOM   2283 C CZ  . ARG B 2 19  ? 178.334 206.408 201.876 1.00 155.24 ? 19  ARG C CZ  1 
ATOM   2284 N NH1 . ARG B 2 19  ? 178.393 206.219 200.568 1.00 155.24 ? 19  ARG C NH1 1 
ATOM   2285 N NH2 . ARG B 2 19  ? 178.104 207.629 202.347 1.00 155.24 ? 19  ARG C NH2 1 
ATOM   2286 N N   . ASP B 2 20  ? 182.342 203.995 206.671 1.00 151.33 ? 20  ASP C N   1 
ATOM   2287 C CA  . ASP B 2 20  ? 183.664 204.378 207.157 1.00 151.33 ? 20  ASP C CA  1 
ATOM   2288 C C   . ASP B 2 20  ? 184.311 203.250 207.952 1.00 151.33 ? 20  ASP C C   1 
ATOM   2289 O O   . ASP B 2 20  ? 185.524 203.029 207.847 1.00 151.33 ? 20  ASP C O   1 
ATOM   2290 C CB  . ASP B 2 20  ? 183.564 205.645 208.006 1.00 151.33 ? 20  ASP C CB  1 
ATOM   2291 C CG  . ASP B 2 20  ? 183.250 206.876 207.179 1.00 151.33 ? 20  ASP C CG  1 
ATOM   2292 O OD1 . ASP B 2 20  ? 183.662 206.923 206.002 1.00 151.33 ? 20  ASP C OD1 1 
ATOM   2293 O OD2 . ASP B 2 20  ? 182.588 207.795 207.707 1.00 151.33 ? 20  ASP C OD2 1 
ATOM   2294 N N   . ALA B 2 21  ? 183.516 202.526 208.746 1.00 141.18 ? 21  ALA C N   1 
ATOM   2295 C CA  . ALA B 2 21  ? 184.047 201.406 209.516 1.00 141.18 ? 21  ALA C CA  1 
ATOM   2296 C C   . ALA B 2 21  ? 184.538 200.288 208.606 1.00 141.18 ? 21  ALA C C   1 
ATOM   2297 O O   . ALA B 2 21  ? 185.627 199.742 208.818 1.00 141.18 ? 21  ALA C O   1 
ATOM   2298 C CB  . ALA B 2 21  ? 182.984 200.884 210.482 1.00 141.18 ? 21  ALA C CB  1 
ATOM   2299 N N   . ARG B 2 22  ? 183.762 199.943 207.576 1.00 121.76 ? 22  ARG C N   1 
ATOM   2300 C CA  . ARG B 2 22  ? 184.210 198.897 206.662 1.00 121.76 ? 22  ARG C CA  1 
ATOM   2301 C C   . ARG B 2 22  ? 185.311 199.372 205.721 1.00 121.76 ? 22  ARG C C   1 
ATOM   2302 O O   . ARG B 2 22  ? 186.062 198.541 205.202 1.00 121.76 ? 22  ARG C O   1 
ATOM   2303 C CB  . ARG B 2 22  ? 183.035 198.339 205.854 1.00 121.76 ? 22  ARG C CB  1 
ATOM   2304 C CG  . ARG B 2 22  ? 182.402 199.310 204.883 1.00 121.76 ? 22  ARG C CG  1 
ATOM   2305 C CD  . ARG B 2 22  ? 181.724 198.578 203.741 1.00 121.76 ? 22  ARG C CD  1 
ATOM   2306 N NE  . ARG B 2 22  ? 180.809 197.547 204.214 1.00 121.76 ? 22  ARG C NE  1 
ATOM   2307 C CZ  . ARG B 2 22  ? 179.502 197.711 204.358 1.00 121.76 ? 22  ARG C CZ  1 
ATOM   2308 N NH1 . ARG B 2 22  ? 178.919 198.870 204.103 1.00 121.76 ? 22  ARG C NH1 1 
ATOM   2309 N NH2 . ARG B 2 22  ? 178.761 196.686 204.767 1.00 121.76 ? 22  ARG C NH2 1 
ATOM   2310 N N   . LYS B 2 23  ? 185.434 200.683 205.497 1.00 135.67 ? 23  LYS C N   1 
ATOM   2311 C CA  . LYS B 2 23  ? 186.555 201.192 204.716 1.00 135.67 ? 23  LYS C CA  1 
ATOM   2312 C C   . LYS B 2 23  ? 187.848 201.152 205.519 1.00 135.67 ? 23  LYS C C   1 
ATOM   2313 O O   . LYS B 2 23  ? 188.899 200.765 204.997 1.00 135.67 ? 23  LYS C O   1 
ATOM   2314 C CB  . LYS B 2 23  ? 186.259 202.615 204.246 1.00 135.67 ? 23  LYS C CB  1 
ATOM   2315 C CG  . LYS B 2 23  ? 187.318 203.205 203.333 1.00 135.67 ? 23  LYS C CG  1 
ATOM   2316 C CD  . LYS B 2 23  ? 187.001 204.651 202.991 1.00 135.67 ? 23  LYS C CD  1 
ATOM   2317 C CE  . LYS B 2 23  ? 187.268 205.566 204.176 1.00 135.67 ? 23  LYS C CE  1 
ATOM   2318 N NZ  . LYS B 2 23  ? 188.715 205.619 204.522 1.00 135.67 ? 23  LYS C NZ  1 
ATOM   2319 N N   . ALA B 2 24  ? 187.790 201.546 206.794 1.00 134.74 ? 24  ALA C N   1 
ATOM   2320 C CA  . ALA B 2 24  ? 188.962 201.465 207.654 1.00 134.74 ? 24  ALA C CA  1 
ATOM   2321 C C   . ALA B 2 24  ? 189.275 200.033 208.064 1.00 134.74 ? 24  ALA C C   1 
ATOM   2322 O O   . ALA B 2 24  ? 190.396 199.757 208.503 1.00 134.74 ? 24  ALA C O   1 
ATOM   2323 C CB  . ALA B 2 24  ? 188.764 202.330 208.899 1.00 134.74 ? 24  ALA C CB  1 
ATOM   2324 N N   . CYS B 2 25  ? 188.311 199.121 207.929 1.00 131.14 ? 25  CYS C N   1 
ATOM   2325 C CA  . CYS B 2 25  ? 188.530 197.730 208.297 1.00 131.14 ? 25  CYS C CA  1 
ATOM   2326 C C   . CYS B 2 25  ? 189.378 196.987 207.271 1.00 131.14 ? 25  CYS C C   1 
ATOM   2327 O O   . CYS B 2 25  ? 189.954 195.944 207.599 1.00 131.14 ? 25  CYS C O   1 
ATOM   2328 C CB  . CYS B 2 25  ? 187.179 197.037 208.481 1.00 131.14 ? 25  CYS C CB  1 
ATOM   2329 S SG  . CYS B 2 25  ? 187.246 195.417 209.258 1.00 131.14 ? 25  CYS C SG  1 
ATOM   2330 N N   . ALA B 2 26  ? 189.476 197.502 206.045 1.00 127.64 ? 26  ALA C N   1 
ATOM   2331 C CA  . ALA B 2 26  ? 190.228 196.847 204.973 1.00 127.64 ? 26  ALA C CA  1 
ATOM   2332 C C   . ALA B 2 26  ? 191.686 197.278 205.060 1.00 127.64 ? 26  ALA C C   1 
ATOM   2333 O O   . ALA B 2 26  ? 192.089 198.305 204.513 1.00 127.64 ? 26  ALA C O   1 
ATOM   2334 C CB  . ALA B 2 26  ? 189.628 197.181 203.614 1.00 127.64 ? 26  ALA C CB  1 
ATOM   2335 N N   . ASP B 2 27  ? 192.490 196.478 205.763 1.00 124.69 ? 27  ASP C N   1 
ATOM   2336 C CA  . ASP B 2 27  ? 193.917 196.766 205.853 1.00 124.69 ? 27  ASP C CA  1 
ATOM   2337 C C   . ASP B 2 27  ? 194.652 196.390 204.572 1.00 124.69 ? 27  ASP C C   1 
ATOM   2338 O O   . ASP B 2 27  ? 195.672 197.006 204.241 1.00 124.69 ? 27  ASP C O   1 
ATOM   2339 C CB  . ASP B 2 27  ? 194.525 196.040 207.053 1.00 124.69 ? 27  ASP C CB  1 
ATOM   2340 C CG  . ASP B 2 27  ? 194.309 194.541 206.998 1.00 124.69 ? 27  ASP C CG  1 
ATOM   2341 O OD1 . ASP B 2 27  ? 193.298 194.105 206.409 1.00 124.69 ? 27  ASP C OD1 1 
ATOM   2342 O OD2 . ASP B 2 27  ? 195.150 193.799 207.549 1.00 124.69 ? 27  ASP C OD2 1 
ATOM   2343 N N   . ALA B 2 28  ? 194.157 195.392 203.843 1.00 114.22 ? 28  ALA C N   1 
ATOM   2344 C CA  . ALA B 2 28  ? 194.806 194.941 202.622 1.00 114.22 ? 28  ALA C CA  1 
ATOM   2345 C C   . ALA B 2 28  ? 193.761 194.344 201.691 1.00 114.22 ? 28  ALA C C   1 
ATOM   2346 O O   . ALA B 2 28  ? 192.660 193.979 202.113 1.00 114.22 ? 28  ALA C O   1 
ATOM   2347 C CB  . ALA B 2 28  ? 195.909 193.918 202.916 1.00 114.22 ? 28  ALA C CB  1 
ATOM   2348 N N   . THR B 2 29  ? 194.119 194.248 200.415 1.00 99.80  ? 29  THR C N   1 
ATOM   2349 C CA  . THR B 2 29  ? 193.256 193.660 199.403 1.00 99.80  ? 29  THR C CA  1 
ATOM   2350 C C   . THR B 2 29  ? 193.722 192.253 199.047 1.00 99.80  ? 29  THR C C   1 
ATOM   2351 O O   . THR B 2 29  ? 194.857 191.856 199.320 1.00 99.80  ? 29  THR C O   1 
ATOM   2352 C CB  . THR B 2 29  ? 193.212 194.525 198.141 1.00 99.80  ? 29  THR C CB  1 
ATOM   2353 O OG1 . THR B 2 29  ? 192.372 193.898 197.164 1.00 99.80  ? 29  THR C OG1 1 
ATOM   2354 C CG2 . THR B 2 29  ? 194.606 194.697 197.563 1.00 99.80  ? 29  THR C CG2 1 
ATOM   2355 N N   . LEU B 2 30  ? 192.815 191.499 198.423 1.00 91.92  ? 30  LEU C N   1 
ATOM   2356 C CA  . LEU B 2 30  ? 193.074 190.098 198.117 1.00 91.92  ? 30  LEU C CA  1 
ATOM   2357 C C   . LEU B 2 30  ? 194.015 189.930 196.928 1.00 91.92  ? 30  LEU C C   1 
ATOM   2358 O O   . LEU B 2 30  ? 194.638 188.870 196.790 1.00 91.92  ? 30  LEU C O   1 
ATOM   2359 C CB  . LEU B 2 30  ? 191.732 189.388 197.894 1.00 91.92  ? 30  LEU C CB  1 
ATOM   2360 C CG  . LEU B 2 30  ? 191.570 187.872 197.751 1.00 91.92  ? 30  LEU C CG  1 
ATOM   2361 C CD1 . LEU B 2 30  ? 190.208 187.470 198.285 1.00 91.92  ? 30  LEU C CD1 1 
ATOM   2362 C CD2 . LEU B 2 30  ? 191.658 187.440 196.311 1.00 91.92  ? 30  LEU C CD2 1 
ATOM   2363 N N   . SER B 2 31  ? 194.150 190.959 196.087 1.00 95.30  ? 31  SER C N   1 
ATOM   2364 C CA  . SER B 2 31  ? 195.029 190.874 194.924 1.00 95.30  ? 31  SER C CA  1 
ATOM   2365 C C   . SER B 2 31  ? 196.495 190.796 195.334 1.00 95.30  ? 31  SER C C   1 
ATOM   2366 O O   . SER B 2 31  ? 197.258 189.978 194.803 1.00 95.30  ? 31  SER C O   1 
ATOM   2367 C CB  . SER B 2 31  ? 194.804 192.078 194.009 1.00 95.30  ? 31  SER C CB  1 
ATOM   2368 O OG  . SER B 2 31  ? 193.452 192.177 193.606 1.00 95.30  ? 31  SER C OG  1 
ATOM   2369 N N   . GLN B 2 32  ? 196.912 191.648 196.271 1.00 98.43  ? 32  GLN C N   1 
ATOM   2370 C CA  . GLN B 2 32  ? 198.312 191.704 196.668 1.00 98.43  ? 32  GLN C CA  1 
ATOM   2371 C C   . GLN B 2 32  ? 198.699 190.589 197.628 1.00 98.43  ? 32  GLN C C   1 
ATOM   2372 O O   . GLN B 2 32  ? 199.882 190.466 197.966 1.00 98.43  ? 32  GLN C O   1 
ATOM   2373 C CB  . GLN B 2 32  ? 198.632 193.067 197.286 1.00 98.43  ? 32  GLN C CB  1 
ATOM   2374 C CG  . GLN B 2 32  ? 197.913 193.362 198.585 1.00 98.43  ? 32  GLN C CG  1 
ATOM   2375 C CD  . GLN B 2 32  ? 198.167 194.775 199.068 1.00 98.43  ? 32  GLN C CD  1 
ATOM   2376 O OE1 . GLN B 2 32  ? 198.939 195.519 198.463 1.00 98.43  ? 32  GLN C OE1 1 
ATOM   2377 N NE2 . GLN B 2 32  ? 197.515 195.155 200.160 1.00 98.43  ? 32  GLN C NE2 1 
ATOM   2378 N N   . ILE B 2 33  ? 197.740 189.790 198.084 1.00 96.43  ? 33  ILE C N   1 
ATOM   2379 C CA  . ILE B 2 33  ? 198.053 188.536 198.757 1.00 96.43  ? 33  ILE C CA  1 
ATOM   2380 C C   . ILE B 2 33  ? 198.067 187.382 197.762 1.00 96.43  ? 33  ILE C C   1 
ATOM   2381 O O   . ILE B 2 33  ? 198.875 186.457 197.880 1.00 96.43  ? 33  ILE C O   1 
ATOM   2382 C CB  . ILE B 2 33  ? 197.049 188.295 199.904 1.00 96.43  ? 33  ILE C CB  1 
ATOM   2383 C CG1 . ILE B 2 33  ? 197.029 189.498 200.847 1.00 96.43  ? 33  ILE C CG1 1 
ATOM   2384 C CG2 . ILE B 2 33  ? 197.400 187.037 200.687 1.00 96.43  ? 33  ILE C CG2 1 
ATOM   2385 C CD1 . ILE B 2 33  ? 195.914 189.455 201.867 1.00 96.43  ? 33  ILE C CD1 1 
ATOM   2386 N N   . THR B 2 34  ? 197.195 187.444 196.754 1.00 91.57  ? 34  THR C N   1 
ATOM   2387 C CA  . THR B 2 34  ? 197.126 186.412 195.728 1.00 91.57  ? 34  THR C CA  1 
ATOM   2388 C C   . THR B 2 34  ? 198.332 186.405 194.797 1.00 91.57  ? 34  THR C C   1 
ATOM   2389 O O   . THR B 2 34  ? 198.782 185.324 194.401 1.00 91.57  ? 34  THR C O   1 
ATOM   2390 C CB  . THR B 2 34  ? 195.853 186.595 194.901 1.00 91.57  ? 34  THR C CB  1 
ATOM   2391 O OG1 . THR B 2 34  ? 194.734 186.718 195.783 1.00 91.57  ? 34  THR C OG1 1 
ATOM   2392 C CG2 . THR B 2 34  ? 195.630 185.413 193.980 1.00 91.57  ? 34  THR C CG2 1 
ATOM   2393 N N   . ASN B 2 35  ? 198.902 187.572 194.485 1.00 95.06  ? 35  ASN C N   1 
ATOM   2394 C CA  . ASN B 2 35  ? 199.816 187.725 193.351 1.00 95.06  ? 35  ASN C CA  1 
ATOM   2395 C C   . ASN B 2 35  ? 201.136 186.954 193.475 1.00 95.06  ? 35  ASN C C   1 
ATOM   2396 O O   . ASN B 2 35  ? 201.984 187.101 192.589 1.00 95.06  ? 35  ASN C O   1 
ATOM   2397 C CB  . ASN B 2 35  ? 200.114 189.210 193.131 1.00 95.06  ? 35  ASN C CB  1 
ATOM   2398 C CG  . ASN B 2 35  ? 200.573 189.908 194.397 1.00 95.06  ? 35  ASN C CG  1 
ATOM   2399 O OD1 . ASN B 2 35  ? 200.688 189.291 195.455 1.00 95.06  ? 35  ASN C OD1 1 
ATOM   2400 N ND2 . ASN B 2 35  ? 200.835 191.206 194.294 1.00 95.06  ? 35  ASN C ND2 1 
ATOM   2401 N N   . ASN B 2 36  ? 201.346 186.148 194.518 1.00 90.94  ? 36  ASN C N   1 
ATOM   2402 C CA  . ASN B 2 36  ? 202.558 185.347 194.641 1.00 90.94  ? 36  ASN C CA  1 
ATOM   2403 C C   . ASN B 2 36  ? 202.264 183.854 194.768 1.00 90.94  ? 36  ASN C C   1 
ATOM   2404 O O   . ASN B 2 36  ? 203.015 183.136 195.435 1.00 90.94  ? 36  ASN C O   1 
ATOM   2405 C CB  . ASN B 2 36  ? 203.395 185.825 195.829 1.00 90.94  ? 36  ASN C CB  1 
ATOM   2406 C CG  . ASN B 2 36  ? 203.908 187.238 195.645 1.00 90.94  ? 36  ASN C CG  1 
ATOM   2407 O OD1 . ASN B 2 36  ? 203.532 188.149 196.382 1.00 90.94  ? 36  ASN C OD1 1 
ATOM   2408 N ND2 . ASN B 2 36  ? 204.769 187.430 194.651 1.00 90.94  ? 36  ASN C ND2 1 
ATOM   2409 N N   . ILE B 2 37  ? 201.189 183.367 194.147 1.00 83.73  ? 37  ILE C N   1 
ATOM   2410 C CA  . ILE B 2 37  ? 200.858 181.949 194.178 1.00 83.73  ? 37  ILE C CA  1 
ATOM   2411 C C   . ILE B 2 37  ? 200.884 181.407 192.756 1.00 83.73  ? 37  ILE C C   1 
ATOM   2412 O O   . ILE B 2 37  ? 200.909 182.155 191.776 1.00 83.73  ? 37  ILE C O   1 
ATOM   2413 C CB  . ILE B 2 37  ? 199.490 181.671 194.836 1.00 83.73  ? 37  ILE C CB  1 
ATOM   2414 C CG1 . ILE B 2 37  ? 198.352 182.176 193.951 1.00 83.73  ? 37  ILE C CG1 1 
ATOM   2415 C CG2 . ILE B 2 37  ? 199.419 182.307 196.215 1.00 83.73  ? 37  ILE C CG2 1 
ATOM   2416 C CD1 . ILE B 2 37  ? 196.985 181.743 194.418 1.00 83.73  ? 37  ILE C CD1 1 
ATOM   2417 N N   . ASP B 2 38  ? 200.885 180.081 192.654 1.00 79.19  ? 38  ASP C N   1 
ATOM   2418 C CA  . ASP B 2 38  ? 200.918 179.438 191.349 1.00 79.19  ? 38  ASP C CA  1 
ATOM   2419 C C   . ASP B 2 38  ? 199.540 179.497 190.694 1.00 79.19  ? 38  ASP C C   1 
ATOM   2420 O O   . ASP B 2 38  ? 198.542 179.106 191.308 1.00 79.19  ? 38  ASP C O   1 
ATOM   2421 C CB  . ASP B 2 38  ? 201.376 177.987 191.476 1.00 79.19  ? 38  ASP C CB  1 
ATOM   2422 C CG  . ASP B 2 38  ? 202.832 177.872 191.879 1.00 79.19  ? 38  ASP C CG  1 
ATOM   2423 O OD1 . ASP B 2 38  ? 203.616 178.785 191.545 1.00 79.19  ? 38  ASP C OD1 1 
ATOM   2424 O OD2 . ASP B 2 38  ? 203.193 176.869 192.529 1.00 79.19  ? 38  ASP C OD2 1 
ATOM   2425 N N   . PRO B 2 39  ? 199.454 179.969 189.454 1.00 74.46  ? 39  PRO C N   1 
ATOM   2426 C CA  . PRO B 2 39  ? 198.150 180.129 188.809 1.00 74.46  ? 39  PRO C CA  1 
ATOM   2427 C C   . PRO B 2 39  ? 197.563 178.802 188.355 1.00 74.46  ? 39  PRO C C   1 
ATOM   2428 O O   . PRO B 2 39  ? 198.251 177.789 188.224 1.00 74.46  ? 39  PRO C O   1 
ATOM   2429 C CB  . PRO B 2 39  ? 198.463 181.028 187.609 1.00 74.46  ? 39  PRO C CB  1 
ATOM   2430 C CG  . PRO B 2 39  ? 199.868 180.694 187.265 1.00 74.46  ? 39  PRO C CG  1 
ATOM   2431 C CD  . PRO B 2 39  ? 200.563 180.354 188.563 1.00 74.46  ? 39  PRO C CD  1 
ATOM   2432 N N   . VAL B 2 40  ? 196.251 178.830 188.124 1.00 67.12  ? 40  VAL C N   1 
ATOM   2433 C CA  . VAL B 2 40  ? 195.556 177.670 187.588 1.00 67.12  ? 40  VAL C CA  1 
ATOM   2434 C C   . VAL B 2 40  ? 195.684 177.666 186.071 1.00 67.12  ? 40  VAL C C   1 
ATOM   2435 O O   . VAL B 2 40  ? 195.497 178.697 185.411 1.00 67.12  ? 40  VAL C O   1 
ATOM   2436 C CB  . VAL B 2 40  ? 194.083 177.684 188.029 1.00 67.12  ? 40  VAL C CB  1 
ATOM   2437 C CG1 . VAL B 2 40  ? 193.360 176.439 187.543 1.00 67.12  ? 40  VAL C CG1 1 
ATOM   2438 C CG2 . VAL B 2 40  ? 193.990 177.805 189.539 1.00 67.12  ? 40  VAL C CG2 1 
ATOM   2439 N N   . GLY B 2 41  ? 196.005 176.506 185.509 1.00 67.14  ? 41  GLY C N   1 
ATOM   2440 C CA  . GLY B 2 41  ? 196.143 176.372 184.076 1.00 67.14  ? 41  GLY C CA  1 
ATOM   2441 C C   . GLY B 2 41  ? 194.801 176.401 183.364 1.00 67.14  ? 41  GLY C C   1 
ATOM   2442 O O   . GLY B 2 41  ? 193.740 176.612 183.953 1.00 67.14  ? 41  GLY C O   1 
ATOM   2443 N N   . ARG B 2 42  ? 194.862 176.189 182.052 1.00 63.10  ? 42  ARG C N   1 
ATOM   2444 C CA  . ARG B 2 42  ? 193.661 176.238 181.230 1.00 63.10  ? 42  ARG C CA  1 
ATOM   2445 C C   . ARG B 2 42  ? 192.758 175.049 181.535 1.00 63.10  ? 42  ARG C C   1 
ATOM   2446 O O   . ARG B 2 42  ? 193.188 173.894 181.470 1.00 63.10  ? 42  ARG C O   1 
ATOM   2447 C CB  . ARG B 2 42  ? 194.034 176.253 179.749 1.00 63.10  ? 42  ARG C CB  1 
ATOM   2448 N N   . ILE B 2 43  ? 191.505 175.336 181.872 1.00 58.58  ? 43  ILE C N   1 
ATOM   2449 C CA  . ILE B 2 43  ? 190.532 174.280 182.184 1.00 58.58  ? 43  ILE C CA  1 
ATOM   2450 C C   . ILE B 2 43  ? 189.879 173.906 180.860 1.00 58.58  ? 43  ILE C C   1 
ATOM   2451 O O   . ILE B 2 43  ? 188.806 174.387 180.487 1.00 58.58  ? 43  ILE C O   1 
ATOM   2452 C CB  . ILE B 2 43  ? 189.521 174.719 183.245 1.00 58.58  ? 43  ILE C CB  1 
ATOM   2453 N N   . GLN B 2 44  ? 190.548 173.017 180.125 1.00 54.68  ? 44  GLN C N   1 
ATOM   2454 C CA  . GLN B 2 44  ? 190.024 172.495 178.863 1.00 54.68  ? 44  GLN C CA  1 
ATOM   2455 C C   . GLN B 2 44  ? 189.078 171.346 179.194 1.00 54.68  ? 44  GLN C C   1 
ATOM   2456 O O   . GLN B 2 44  ? 189.415 170.163 179.102 1.00 54.68  ? 44  GLN C O   1 
ATOM   2457 C CB  . GLN B 2 44  ? 191.156 172.051 177.946 1.00 54.68  ? 44  GLN C CB  1 
ATOM   2458 N N   . MET B 2 45  ? 187.866 171.711 179.594 1.00 49.21  ? 45  MET C N   1 
ATOM   2459 C CA  . MET B 2 45  ? 186.872 170.753 180.066 1.00 49.21  ? 45  MET C CA  1 
ATOM   2460 C C   . MET B 2 45  ? 185.945 170.425 178.902 1.00 49.21  ? 45  MET C C   1 
ATOM   2461 O O   . MET B 2 45  ? 185.094 171.232 178.526 1.00 49.21  ? 45  MET C O   1 
ATOM   2462 C CB  . MET B 2 45  ? 186.108 171.322 181.256 1.00 49.21  ? 45  MET C CB  1 
ATOM   2463 C CG  . MET B 2 45  ? 186.963 171.547 182.493 1.00 49.21  ? 45  MET C CG  1 
ATOM   2464 S SD  . MET B 2 45  ? 186.127 172.508 183.770 1.00 49.21  ? 45  MET C SD  1 
ATOM   2465 C CE  . MET B 2 45  ? 184.813 171.388 184.240 1.00 49.21  ? 45  MET C CE  1 
ATOM   2466 N N   . ARG B 2 46  ? 186.126 169.245 178.317 1.00 48.34  ? 46  ARG C N   1 
ATOM   2467 C CA  . ARG B 2 46  ? 185.242 168.807 177.250 1.00 48.34  ? 46  ARG C CA  1 
ATOM   2468 C C   . ARG B 2 46  ? 183.952 168.237 177.825 1.00 48.34  ? 46  ARG C C   1 
ATOM   2469 O O   . ARG B 2 46  ? 183.911 167.755 178.960 1.00 48.34  ? 46  ARG C O   1 
ATOM   2470 C CB  . ARG B 2 46  ? 185.931 167.763 176.371 1.00 48.34  ? 46  ARG C CB  1 
ATOM   2471 C CG  . ARG B 2 46  ? 186.979 168.341 175.435 1.00 48.34  ? 46  ARG C CG  1 
ATOM   2472 C CD  . ARG B 2 46  ? 188.137 167.374 175.231 1.00 48.34  ? 46  ARG C CD  1 
ATOM   2473 N NE  . ARG B 2 46  ? 189.069 167.366 176.354 1.00 48.34  ? 46  ARG C NE  1 
ATOM   2474 C CZ  . ARG B 2 46  ? 189.944 168.326 176.628 1.00 48.34  ? 46  ARG C CZ  1 
ATOM   2475 N NH1 . ARG B 2 46  ? 190.066 169.396 175.859 1.00 48.34  ? 46  ARG C NH1 1 
ATOM   2476 N NH2 . ARG B 2 46  ? 190.723 168.205 177.699 1.00 48.34  ? 46  ARG C NH2 1 
ATOM   2477 N N   . THR B 2 47  ? 182.893 168.299 177.025 1.00 41.99  ? 47  THR C N   1 
ATOM   2478 C CA  . THR B 2 47  ? 181.594 167.808 177.456 1.00 41.99  ? 47  THR C CA  1 
ATOM   2479 C C   . THR B 2 47  ? 181.608 166.293 177.616 1.00 41.99  ? 47  THR C C   1 
ATOM   2480 O O   . THR B 2 47  ? 182.361 165.578 176.952 1.00 41.99  ? 47  THR C O   1 
ATOM   2481 C CB  . THR B 2 47  ? 180.508 168.224 176.465 1.00 41.99  ? 47  THR C CB  1 
ATOM   2482 O OG1 . THR B 2 47  ? 179.237 167.734 176.913 1.00 41.99  ? 47  THR C OG1 1 
ATOM   2483 C CG2 . THR B 2 47  ? 180.805 167.700 175.071 1.00 41.99  ? 47  THR C CG2 1 
ATOM   2484 N N   . ARG B 2 48  ? 180.787 165.810 178.543 1.00 43.41  ? 48  ARG C N   1 
ATOM   2485 C CA  . ARG B 2 48  ? 180.666 164.381 178.791 1.00 43.41  ? 48  ARG C CA  1 
ATOM   2486 C C   . ARG B 2 48  ? 179.253 163.875 178.563 1.00 43.41  ? 48  ARG C C   1 
ATOM   2487 O O   . ARG B 2 48  ? 179.064 162.850 177.898 1.00 43.41  ? 48  ARG C O   1 
ATOM   2488 C CB  . ARG B 2 48  ? 181.115 164.055 180.220 1.00 43.41  ? 48  ARG C CB  1 
ATOM   2489 C CG  . ARG B 2 48  ? 182.528 164.495 180.516 1.00 43.41  ? 48  ARG C CG  1 
ATOM   2490 C CD  . ARG B 2 48  ? 183.518 163.715 179.690 1.00 43.41  ? 48  ARG C CD  1 
ATOM   2491 N NE  . ARG B 2 48  ? 184.740 164.472 179.460 1.00 43.41  ? 48  ARG C NE  1 
ATOM   2492 C CZ  . ARG B 2 48  ? 185.861 164.306 180.146 1.00 43.41  ? 48  ARG C CZ  1 
ATOM   2493 N NH1 . ARG B 2 48  ? 185.955 163.400 181.106 1.00 43.41  ? 48  ARG C NH1 1 
ATOM   2494 N NH2 . ARG B 2 48  ? 186.915 165.065 179.861 1.00 43.41  ? 48  ARG C NH2 1 
ATOM   2495 N N   . ARG B 2 49  ? 178.254 164.563 179.104 1.00 43.53  ? 49  ARG C N   1 
ATOM   2496 C CA  . ARG B 2 49  ? 176.858 164.191 178.939 1.00 43.53  ? 49  ARG C CA  1 
ATOM   2497 C C   . ARG B 2 49  ? 176.098 165.401 178.421 1.00 43.53  ? 49  ARG C C   1 
ATOM   2498 O O   . ARG B 2 49  ? 176.363 166.529 178.845 1.00 43.53  ? 49  ARG C O   1 
ATOM   2499 C CB  . ARG B 2 49  ? 176.241 163.716 180.257 1.00 43.53  ? 49  ARG C CB  1 
ATOM   2500 C CG  . ARG B 2 49  ? 177.107 162.773 181.071 1.00 43.53  ? 49  ARG C CG  1 
ATOM   2501 C CD  . ARG B 2 49  ? 177.197 161.397 180.454 1.00 43.53  ? 49  ARG C CD  1 
ATOM   2502 N NE  . ARG B 2 49  ? 178.322 160.652 181.004 1.00 43.53  ? 49  ARG C NE  1 
ATOM   2503 C CZ  . ARG B 2 49  ? 178.703 159.453 180.589 1.00 43.53  ? 49  ARG C CZ  1 
ATOM   2504 N NH1 . ARG B 2 49  ? 178.079 158.834 179.601 1.00 43.53  ? 49  ARG C NH1 1 
ATOM   2505 N NH2 . ARG B 2 49  ? 179.736 158.861 181.179 1.00 43.53  ? 49  ARG C NH2 1 
ATOM   2506 N N   . THR B 2 50  ? 175.177 165.170 177.496 1.00 41.57  ? 50  THR C N   1 
ATOM   2507 C CA  . THR B 2 50  ? 174.257 166.197 177.016 1.00 41.57  ? 50  THR C CA  1 
ATOM   2508 C C   . THR B 2 50  ? 172.844 165.654 177.197 1.00 41.57  ? 50  THR C C   1 
ATOM   2509 O O   . THR B 2 50  ? 172.348 164.898 176.357 1.00 41.57  ? 50  THR C O   1 
ATOM   2510 C CB  . THR B 2 50  ? 174.548 166.555 175.563 1.00 41.57  ? 50  THR C CB  1 
ATOM   2511 O OG1 . THR B 2 50  ? 175.929 166.918 175.430 1.00 41.57  ? 50  THR C OG1 1 
ATOM   2512 C CG2 . THR B 2 50  ? 173.680 167.713 175.117 1.00 41.57  ? 50  THR C CG2 1 
ATOM   2513 N N   . LEU B 2 51  ? 172.190 166.051 178.289 1.00 48.36  ? 51  LEU C N   1 
ATOM   2514 C CA  . LEU B 2 51  ? 170.903 165.472 178.678 1.00 48.36  ? 51  LEU C CA  1 
ATOM   2515 C C   . LEU B 2 51  ? 169.795 166.000 177.765 1.00 48.36  ? 51  LEU C C   1 
ATOM   2516 O O   . LEU B 2 51  ? 169.002 166.875 178.115 1.00 48.36  ? 51  LEU C O   1 
ATOM   2517 C CB  . LEU B 2 51  ? 170.610 165.754 180.144 1.00 48.36  ? 51  LEU C CB  1 
ATOM   2518 C CG  . LEU B 2 51  ? 171.658 165.224 181.125 1.00 48.36  ? 51  LEU C CG  1 
ATOM   2519 C CD1 . LEU B 2 51  ? 171.365 165.673 182.544 1.00 48.36  ? 51  LEU C CD1 1 
ATOM   2520 C CD2 . LEU B 2 51  ? 171.736 163.711 181.051 1.00 48.36  ? 51  LEU C CD2 1 
ATOM   2521 N N   . ARG B 2 52  ? 169.756 165.437 176.562 1.00 49.14  ? 52  ARG C N   1 
ATOM   2522 C CA  . ARG B 2 52  ? 168.717 165.767 175.600 1.00 49.14  ? 52  ARG C CA  1 
ATOM   2523 C C   . ARG B 2 52  ? 167.392 165.135 176.008 1.00 49.14  ? 52  ARG C C   1 
ATOM   2524 O O   . ARG B 2 52  ? 167.350 164.075 176.637 1.00 49.14  ? 52  ARG C O   1 
ATOM   2525 C CB  . ARG B 2 52  ? 169.114 165.286 174.205 1.00 49.14  ? 52  ARG C CB  1 
ATOM   2526 C CG  . ARG B 2 52  ? 169.839 166.323 173.365 1.00 49.14  ? 52  ARG C CG  1 
ATOM   2527 C CD  . ARG B 2 52  ? 170.330 165.721 172.055 1.00 49.14  ? 52  ARG C CD  1 
ATOM   2528 N NE  . ARG B 2 52  ? 171.635 165.085 172.193 1.00 49.14  ? 52  ARG C NE  1 
ATOM   2529 C CZ  . ARG B 2 52  ? 172.794 165.718 172.081 1.00 49.14  ? 52  ARG C CZ  1 
ATOM   2530 N NH1 . ARG B 2 52  ? 172.852 167.013 171.822 1.00 49.14  ? 52  ARG C NH1 1 
ATOM   2531 N NH2 . ARG B 2 52  ? 173.924 165.034 172.230 1.00 49.14  ? 52  ARG C NH2 1 
ATOM   2532 N N   . GLY B 2 53  ? 166.299 165.786 175.623 1.00 48.32  ? 53  GLY C N   1 
ATOM   2533 C CA  . GLY B 2 53  ? 164.980 165.295 175.964 1.00 48.32  ? 53  GLY C CA  1 
ATOM   2534 C C   . GLY B 2 53  ? 163.996 166.398 176.285 1.00 48.32  ? 53  GLY C C   1 
ATOM   2535 O O   . GLY B 2 53  ? 162.783 166.214 176.144 1.00 48.32  ? 53  GLY C O   1 
ATOM   2536 N N   . HIS B 2 54  ? 164.502 167.546 176.725 1.00 50.33  ? 54  HIS C N   1 
ATOM   2537 C CA  . HIS B 2 54  ? 163.645 168.704 176.923 1.00 50.33  ? 54  HIS C CA  1 
ATOM   2538 C C   . HIS B 2 54  ? 163.196 169.273 175.583 1.00 50.33  ? 54  HIS C C   1 
ATOM   2539 O O   . HIS B 2 54  ? 163.950 169.304 174.608 1.00 50.33  ? 54  HIS C O   1 
ATOM   2540 C CB  . HIS B 2 54  ? 164.363 169.785 177.729 1.00 50.33  ? 54  HIS C CB  1 
ATOM   2541 C CG  . HIS B 2 54  ? 164.330 169.558 179.207 1.00 50.33  ? 54  HIS C CG  1 
ATOM   2542 N ND1 . HIS B 2 54  ? 165.322 168.879 179.880 1.00 50.33  ? 54  HIS C ND1 1 
ATOM   2543 C CD2 . HIS B 2 54  ? 163.418 169.916 180.141 1.00 50.33  ? 54  HIS C CD2 1 
ATOM   2544 C CE1 . HIS B 2 54  ? 165.025 168.834 181.166 1.00 50.33  ? 54  HIS C CE1 1 
ATOM   2545 N NE2 . HIS B 2 54  ? 163.876 169.457 181.351 1.00 50.33  ? 54  HIS C NE2 1 
ATOM   2546 N N   . LEU B 2 55  ? 161.942 169.717 175.543 1.00 53.96  ? 55  LEU C N   1 
ATOM   2547 C CA  . LEU B 2 55  ? 161.361 170.312 174.349 1.00 53.96  ? 55  LEU C CA  1 
ATOM   2548 C C   . LEU B 2 55  ? 161.132 171.810 174.499 1.00 53.96  ? 55  LEU C C   1 
ATOM   2549 O O   . LEU B 2 55  ? 160.489 172.417 173.636 1.00 53.96  ? 55  LEU C O   1 
ATOM   2550 C CB  . LEU B 2 55  ? 160.046 169.613 174.004 1.00 53.96  ? 55  LEU C CB  1 
ATOM   2551 C CG  . LEU B 2 55  ? 160.178 168.190 173.463 1.00 53.96  ? 55  LEU C CG  1 
ATOM   2552 C CD1 . LEU B 2 55  ? 158.831 167.486 173.472 1.00 53.96  ? 55  LEU C CD1 1 
ATOM   2553 C CD2 . LEU B 2 55  ? 160.769 168.207 172.065 1.00 53.96  ? 55  LEU C CD2 1 
ATOM   2554 N N   . ALA B 2 56  ? 161.641 172.421 175.565 1.00 53.80  ? 56  ALA C N   1 
ATOM   2555 C CA  . ALA B 2 56  ? 161.388 173.828 175.831 1.00 53.80  ? 56  ALA C CA  1 
ATOM   2556 C C   . ALA B 2 56  ? 162.590 174.424 176.552 1.00 53.80  ? 56  ALA C C   1 
ATOM   2557 O O   . ALA B 2 56  ? 163.619 173.772 176.739 1.00 53.80  ? 56  ALA C O   1 
ATOM   2558 C CB  . ALA B 2 56  ? 160.100 174.010 176.641 1.00 53.80  ? 56  ALA C CB  1 
ATOM   2559 N N   . LYS B 2 57  ? 162.440 175.675 176.969 1.00 50.48  ? 57  LYS C N   1 
ATOM   2560 C CA  . LYS B 2 57  ? 163.545 176.425 177.547 1.00 50.48  ? 57  LYS C CA  1 
ATOM   2561 C C   . LYS B 2 57  ? 163.782 176.019 178.998 1.00 50.48  ? 57  LYS C C   1 
ATOM   2562 O O   . LYS B 2 57  ? 162.871 176.079 179.826 1.00 50.48  ? 57  LYS C O   1 
ATOM   2563 C CB  . LYS B 2 57  ? 163.240 177.917 177.448 1.00 50.48  ? 57  LYS C CB  1 
ATOM   2564 C CG  . LYS B 2 57  ? 164.309 178.827 177.985 1.00 50.48  ? 57  LYS C CG  1 
ATOM   2565 C CD  . LYS B 2 57  ? 163.875 180.277 177.861 1.00 50.48  ? 57  LYS C CD  1 
ATOM   2566 C CE  . LYS B 2 57  ? 163.762 180.695 176.406 1.00 50.48  ? 57  LYS C CE  1 
ATOM   2567 N NZ  . LYS B 2 57  ? 163.601 182.165 176.271 1.00 50.48  ? 57  LYS C NZ  1 
ATOM   2568 N N   . ILE B 2 58  ? 165.019 175.634 179.308 1.00 49.26  ? 58  ILE C N   1 
ATOM   2569 C CA  . ILE B 2 58  ? 165.410 175.181 180.640 1.00 49.26  ? 58  ILE C CA  1 
ATOM   2570 C C   . ILE B 2 58  ? 165.901 176.384 181.433 1.00 49.26  ? 58  ILE C C   1 
ATOM   2571 O O   . ILE B 2 58  ? 166.737 177.154 180.946 1.00 49.26  ? 58  ILE C O   1 
ATOM   2572 C CB  . ILE B 2 58  ? 166.501 174.099 180.557 1.00 49.26  ? 58  ILE C CB  1 
ATOM   2573 C CG1 . ILE B 2 58  ? 165.954 172.824 179.916 1.00 49.26  ? 58  ILE C CG1 1 
ATOM   2574 C CG2 . ILE B 2 58  ? 167.078 173.794 181.929 1.00 49.26  ? 58  ILE C CG2 1 
ATOM   2575 C CD1 . ILE B 2 58  ? 167.028 171.836 179.532 1.00 49.26  ? 58  ILE C CD1 1 
ATOM   2576 N N   . TYR B 2 59  ? 165.390 176.551 182.655 1.00 51.26  ? 59  TYR C N   1 
ATOM   2577 C CA  . TYR B 2 59  ? 165.791 177.673 183.495 1.00 51.26  ? 59  TYR C CA  1 
ATOM   2578 C C   . TYR B 2 59  ? 166.567 177.290 184.745 1.00 51.26  ? 59  TYR C C   1 
ATOM   2579 O O   . TYR B 2 59  ? 167.441 178.051 185.158 1.00 51.26  ? 59  TYR C O   1 
ATOM   2580 C CB  . TYR B 2 59  ? 164.570 178.496 183.922 1.00 51.26  ? 59  TYR C CB  1 
ATOM   2581 C CG  . TYR B 2 59  ? 164.176 179.564 182.931 1.00 51.26  ? 59  TYR C CG  1 
ATOM   2582 C CD1 . TYR B 2 59  ? 164.892 180.750 182.840 1.00 51.26  ? 59  TYR C CD1 1 
ATOM   2583 C CD2 . TYR B 2 59  ? 163.076 179.399 182.107 1.00 51.26  ? 59  TYR C CD2 1 
ATOM   2584 C CE1 . TYR B 2 59  ? 164.533 181.731 181.938 1.00 51.26  ? 59  TYR C CE1 1 
ATOM   2585 C CE2 . TYR B 2 59  ? 162.706 180.373 181.206 1.00 51.26  ? 59  TYR C CE2 1 
ATOM   2586 C CZ  . TYR B 2 59  ? 163.438 181.537 181.126 1.00 51.26  ? 59  TYR C CZ  1 
ATOM   2587 O OH  . TYR B 2 59  ? 163.074 182.512 180.228 1.00 51.26  ? 59  TYR C OH  1 
ATOM   2588 N N   . ALA B 2 60  ? 166.277 176.150 185.368 1.00 50.23  ? 60  ALA C N   1 
ATOM   2589 C CA  . ALA B 2 60  ? 166.870 175.842 186.661 1.00 50.23  ? 60  ALA C CA  1 
ATOM   2590 C C   . ALA B 2 60  ? 167.280 174.379 186.735 1.00 50.23  ? 60  ALA C C   1 
ATOM   2591 O O   . ALA B 2 60  ? 166.721 173.521 186.048 1.00 50.23  ? 60  ALA C O   1 
ATOM   2592 C CB  . ALA B 2 60  ? 165.907 176.168 187.809 1.00 50.23  ? 60  ALA C CB  1 
ATOM   2593 N N   . MET B 2 61  ? 168.271 174.111 187.584 1.00 48.00  ? 61  MET C N   1 
ATOM   2594 C CA  . MET B 2 61  ? 168.697 172.756 187.900 1.00 48.00  ? 61  MET C CA  1 
ATOM   2595 C C   . MET B 2 61  ? 169.265 172.733 189.312 1.00 48.00  ? 61  MET C C   1 
ATOM   2596 O O   . MET B 2 61  ? 169.706 173.756 189.840 1.00 48.00  ? 61  MET C O   1 
ATOM   2597 C CB  . MET B 2 61  ? 169.723 172.227 186.885 1.00 48.00  ? 61  MET C CB  1 
ATOM   2598 C CG  . MET B 2 61  ? 170.935 173.123 186.643 1.00 48.00  ? 61  MET C CG  1 
ATOM   2599 S SD  . MET B 2 61  ? 172.258 173.086 187.868 1.00 48.00  ? 61  MET C SD  1 
ATOM   2600 C CE  . MET B 2 61  ? 172.756 171.374 187.766 1.00 48.00  ? 61  MET C CE  1 
ATOM   2601 N N   . HIS B 2 62  ? 169.258 171.546 189.917 1.00 49.31  ? 62  HIS C N   1 
ATOM   2602 C CA  . HIS B 2 62  ? 169.846 171.361 191.235 1.00 49.31  ? 62  HIS C CA  1 
ATOM   2603 C C   . HIS B 2 62  ? 170.257 169.908 191.407 1.00 49.31  ? 62  HIS C C   1 
ATOM   2604 O O   . HIS B 2 62  ? 169.552 168.998 190.963 1.00 49.31  ? 62  HIS C O   1 
ATOM   2605 C CB  . HIS B 2 62  ? 168.881 171.759 192.354 1.00 49.31  ? 62  HIS C CB  1 
ATOM   2606 C CG  . HIS B 2 62  ? 169.552 172.017 193.668 1.00 49.31  ? 62  HIS C CG  1 
ATOM   2607 N ND1 . HIS B 2 62  ? 168.889 171.926 194.873 1.00 49.31  ? 62  HIS C ND1 1 
ATOM   2608 C CD2 . HIS B 2 62  ? 170.823 172.373 193.966 1.00 49.31  ? 62  HIS C CD2 1 
ATOM   2609 C CE1 . HIS B 2 62  ? 169.726 172.202 195.857 1.00 49.31  ? 62  HIS C CE1 1 
ATOM   2610 N NE2 . HIS B 2 62  ? 170.906 172.479 195.333 1.00 49.31  ? 62  HIS C NE2 1 
ATOM   2611 N N   . TRP B 2 63  ? 171.397 169.707 192.060 1.00 50.94  ? 63  TRP C N   1 
ATOM   2612 C CA  . TRP B 2 63  ? 171.931 168.382 192.324 1.00 50.94  ? 63  TRP C CA  1 
ATOM   2613 C C   . TRP B 2 63  ? 171.417 167.874 193.668 1.00 50.94  ? 63  TRP C C   1 
ATOM   2614 O O   . TRP B 2 63  ? 170.635 168.534 194.358 1.00 50.94  ? 63  TRP C O   1 
ATOM   2615 C CB  . TRP B 2 63  ? 173.457 168.425 192.316 1.00 50.94  ? 63  TRP C CB  1 
ATOM   2616 C CG  . TRP B 2 63  ? 174.059 168.486 190.952 1.00 50.94  ? 63  TRP C CG  1 
ATOM   2617 C CD1 . TRP B 2 63  ? 174.637 169.570 190.368 1.00 50.94  ? 63  TRP C CD1 1 
ATOM   2618 C CD2 . TRP B 2 63  ? 174.163 167.417 190.006 1.00 50.94  ? 63  TRP C CD2 1 
ATOM   2619 N NE1 . TRP B 2 63  ? 175.087 169.250 189.113 1.00 50.94  ? 63  TRP C NE1 1 
ATOM   2620 C CE2 . TRP B 2 63  ? 174.809 167.932 188.866 1.00 50.94  ? 63  TRP C CE2 1 
ATOM   2621 C CE3 . TRP B 2 63  ? 173.776 166.073 190.013 1.00 50.94  ? 63  TRP C CE3 1 
ATOM   2622 C CZ2 . TRP B 2 63  ? 175.074 167.155 187.743 1.00 50.94  ? 63  TRP C CZ2 1 
ATOM   2623 C CZ3 . TRP B 2 63  ? 174.035 165.303 188.895 1.00 50.94  ? 63  TRP C CZ3 1 
ATOM   2624 C CH2 . TRP B 2 63  ? 174.680 165.846 187.776 1.00 50.94  ? 63  TRP C CH2 1 
ATOM   2625 N N   . GLY B 2 64  ? 171.869 166.681 194.053 1.00 61.64  ? 64  GLY C N   1 
ATOM   2626 C CA  . GLY B 2 64  ? 171.674 166.168 195.386 1.00 61.64  ? 64  GLY C CA  1 
ATOM   2627 C C   . GLY B 2 64  ? 172.926 166.310 196.232 1.00 61.64  ? 64  GLY C C   1 
ATOM   2628 O O   . GLY B 2 64  ? 173.842 167.073 195.917 1.00 61.64  ? 64  GLY C O   1 
ATOM   2629 N N   . THR B 2 65  ? 172.949 165.562 197.338 1.00 64.89  ? 65  THR C N   1 
ATOM   2630 C CA  . THR B 2 65  ? 174.190 165.434 198.095 1.00 64.89  ? 65  THR C CA  1 
ATOM   2631 C C   . THR B 2 65  ? 175.244 164.685 197.297 1.00 64.89  ? 65  THR C C   1 
ATOM   2632 O O   . THR B 2 65  ? 176.440 164.971 197.422 1.00 64.89  ? 65  THR C O   1 
ATOM   2633 C CB  . THR B 2 65  ? 173.947 164.721 199.425 1.00 64.89  ? 65  THR C CB  1 
ATOM   2634 O OG1 . THR B 2 65  ? 173.386 163.423 199.183 1.00 64.89  ? 65  THR C OG1 1 
ATOM   2635 C CG2 . THR B 2 65  ? 173.021 165.525 200.303 1.00 64.89  ? 65  THR C CG2 1 
ATOM   2636 N N   . ASP B 2 66  ? 174.822 163.731 196.480 1.00 61.48  ? 66  ASP C N   1 
ATOM   2637 C CA  . ASP B 2 66  ? 175.695 162.981 195.600 1.00 61.48  ? 66  ASP C CA  1 
ATOM   2638 C C   . ASP B 2 66  ? 175.423 163.390 194.158 1.00 61.48  ? 66  ASP C C   1 
ATOM   2639 O O   . ASP B 2 66  ? 174.524 164.188 193.872 1.00 61.48  ? 66  ASP C O   1 
ATOM   2640 C CB  . ASP B 2 66  ? 175.484 161.481 195.812 1.00 61.48  ? 66  ASP C CB  1 
ATOM   2641 C CG  . ASP B 2 66  ? 174.043 161.061 195.595 1.00 61.48  ? 66  ASP C CG  1 
ATOM   2642 O OD1 . ASP B 2 66  ? 173.146 161.921 195.725 1.00 61.48  ? 66  ASP C OD1 1 
ATOM   2643 O OD2 . ASP B 2 66  ? 173.805 159.872 195.298 1.00 61.48  ? 66  ASP C OD2 1 
ATOM   2644 N N   . SER B 2 67  ? 176.198 162.824 193.240 1.00 59.32  ? 67  SER C N   1 
ATOM   2645 C CA  . SER B 2 67  ? 175.963 163.005 191.814 1.00 59.32  ? 67  SER C CA  1 
ATOM   2646 C C   . SER B 2 67  ? 174.882 162.039 191.349 1.00 59.32  ? 67  SER C C   1 
ATOM   2647 O O   . SER B 2 67  ? 174.084 161.565 192.166 1.00 59.32  ? 67  SER C O   1 
ATOM   2648 C CB  . SER B 2 67  ? 177.254 162.804 191.023 1.00 59.32  ? 67  SER C CB  1 
ATOM   2649 O OG  . SER B 2 67  ? 178.263 163.689 191.473 1.00 59.32  ? 67  SER C OG  1 
ATOM   2650 N N   . ARG B 2 68  ? 174.787 161.842 190.027 1.00 59.83  ? 68  ARG C N   1 
ATOM   2651 C CA  . ARG B 2 68  ? 173.976 160.822 189.355 1.00 59.83  ? 68  ARG C CA  1 
ATOM   2652 C C   . ARG B 2 68  ? 172.488 161.185 189.365 1.00 59.83  ? 68  ARG C C   1 
ATOM   2653 O O   . ARG B 2 68  ? 171.704 160.649 188.574 1.00 59.83  ? 68  ARG C O   1 
ATOM   2654 C CB  . ARG B 2 68  ? 174.267 159.436 189.984 1.00 59.83  ? 68  ARG C CB  1 
ATOM   2655 C CG  . ARG B 2 68  ? 173.181 158.362 189.978 1.00 59.83  ? 68  ARG C CG  1 
ATOM   2656 C CD  . ARG B 2 68  ? 173.728 157.025 190.442 1.00 59.83  ? 68  ARG C CD  1 
ATOM   2657 N NE  . ARG B 2 68  ? 174.806 156.544 189.587 1.00 59.83  ? 68  ARG C NE  1 
ATOM   2658 C CZ  . ARG B 2 68  ? 174.624 155.860 188.466 1.00 59.83  ? 68  ARG C CZ  1 
ATOM   2659 N NH1 . ARG B 2 68  ? 173.411 155.561 188.029 1.00 59.83  ? 68  ARG C NH1 1 
ATOM   2660 N NH2 . ARG B 2 68  ? 175.683 155.462 187.769 1.00 59.83  ? 68  ARG C NH2 1 
ATOM   2661 N N   . LEU B 2 69  ? 172.105 162.191 190.144 1.00 54.96  ? 69  LEU C N   1 
ATOM   2662 C CA  . LEU B 2 69  ? 170.705 162.562 190.259 1.00 54.96  ? 69  LEU C CA  1 
ATOM   2663 C C   . LEU B 2 69  ? 170.594 164.076 190.298 1.00 54.96  ? 69  LEU C C   1 
ATOM   2664 O O   . LEU B 2 69  ? 171.118 164.715 191.215 1.00 54.96  ? 69  LEU C O   1 
ATOM   2665 C CB  . LEU B 2 69  ? 170.077 161.946 191.514 1.00 54.96  ? 69  LEU C CB  1 
ATOM   2666 C CG  . LEU B 2 69  ? 169.361 160.604 191.344 1.00 54.96  ? 69  LEU C CG  1 
ATOM   2667 C CD1 . LEU B 2 69  ? 168.679 160.200 192.635 1.00 54.96  ? 69  LEU C CD1 1 
ATOM   2668 C CD2 . LEU B 2 69  ? 168.357 160.658 190.208 1.00 54.96  ? 69  LEU C CD2 1 
ATOM   2669 N N   . LEU B 2 70  ? 169.916 164.644 189.304 1.00 52.22  ? 70  LEU C N   1 
ATOM   2670 C CA  . LEU B 2 70  ? 169.629 166.070 189.296 1.00 52.22  ? 70  LEU C CA  1 
ATOM   2671 C C   . LEU B 2 70  ? 168.241 166.290 188.715 1.00 52.22  ? 70  LEU C C   1 
ATOM   2672 O O   . LEU B 2 70  ? 167.726 165.461 187.960 1.00 52.22  ? 70  LEU C O   1 
ATOM   2673 C CB  . LEU B 2 70  ? 170.668 166.883 188.507 1.00 52.22  ? 70  LEU C CB  1 
ATOM   2674 C CG  . LEU B 2 70  ? 170.737 166.867 186.977 1.00 52.22  ? 70  LEU C CG  1 
ATOM   2675 C CD1 . LEU B 2 70  ? 171.577 168.036 186.502 1.00 52.22  ? 70  LEU C CD1 1 
ATOM   2676 C CD2 . LEU B 2 70  ? 171.320 165.575 186.452 1.00 52.22  ? 70  LEU C CD2 1 
ATOM   2677 N N   . VAL B 2 71  ? 167.643 167.416 189.082 1.00 53.23  ? 71  VAL C N   1 
ATOM   2678 C CA  . VAL B 2 71  ? 166.309 167.788 188.636 1.00 53.23  ? 71  VAL C CA  1 
ATOM   2679 C C   . VAL B 2 71  ? 166.447 168.956 187.667 1.00 53.23  ? 71  VAL C C   1 
ATOM   2680 O O   . VAL B 2 71  ? 167.402 169.737 187.740 1.00 53.23  ? 71  VAL C O   1 
ATOM   2681 C CB  . VAL B 2 71  ? 165.403 168.124 189.845 1.00 53.23  ? 71  VAL C CB  1 
ATOM   2682 C CG1 . VAL B 2 71  ? 165.789 169.454 190.486 1.00 53.23  ? 71  VAL C CG1 1 
ATOM   2683 C CG2 . VAL B 2 71  ? 163.932 168.089 189.466 1.00 53.23  ? 71  VAL C CG2 1 
ATOM   2684 N N   . SER B 2 72  ? 165.518 169.042 186.717 1.00 51.83  ? 72  SER C N   1 
ATOM   2685 C CA  . SER B 2 72  ? 165.568 170.078 185.697 1.00 51.83  ? 72  SER C CA  1 
ATOM   2686 C C   . SER B 2 72  ? 164.175 170.638 185.454 1.00 51.83  ? 72  SER C C   1 
ATOM   2687 O O   . SER B 2 72  ? 163.193 169.895 185.380 1.00 51.83  ? 72  SER C O   1 
ATOM   2688 C CB  . SER B 2 72  ? 166.152 169.545 184.391 1.00 51.83  ? 72  SER C CB  1 
ATOM   2689 O OG  . SER B 2 72  ? 167.496 169.153 184.577 1.00 51.83  ? 72  SER C OG  1 
ATOM   2690 N N   . ALA B 2 73  ? 164.108 171.956 185.296 1.00 51.74  ? 73  ALA C N   1 
ATOM   2691 C CA  . ALA B 2 73  ? 162.849 172.667 185.162 1.00 51.74  ? 73  ALA C CA  1 
ATOM   2692 C C   . ALA B 2 73  ? 162.804 173.401 183.831 1.00 51.74  ? 73  ALA C C   1 
ATOM   2693 O O   . ALA B 2 73  ? 163.766 174.064 183.436 1.00 51.74  ? 73  ALA C O   1 
ATOM   2694 C CB  . ALA B 2 73  ? 162.653 173.660 186.308 1.00 51.74  ? 73  ALA C CB  1 
ATOM   2695 N N   . SER B 2 74  ? 161.667 173.286 183.149 1.00 56.34  ? 74  SER C N   1 
ATOM   2696 C CA  . SER B 2 74  ? 161.490 173.918 181.849 1.00 56.34  ? 74  SER C CA  1 
ATOM   2697 C C   . SER B 2 74  ? 160.006 174.165 181.617 1.00 56.34  ? 74  SER C C   1 
ATOM   2698 O O   . SER B 2 74  ? 159.146 173.503 182.203 1.00 56.34  ? 74  SER C O   1 
ATOM   2699 C CB  . SER B 2 74  ? 162.080 173.060 180.730 1.00 56.34  ? 74  SER C CB  1 
ATOM   2700 O OG  . SER B 2 74  ? 161.790 173.619 179.464 1.00 56.34  ? 74  SER C OG  1 
ATOM   2701 N N   . GLN B 2 75  ? 159.715 175.100 180.711 1.00 57.14  ? 75  GLN C N   1 
ATOM   2702 C CA  . GLN B 2 75  ? 158.357 175.587 180.485 1.00 57.14  ? 75  GLN C CA  1 
ATOM   2703 C C   . GLN B 2 75  ? 157.461 174.600 179.746 1.00 57.14  ? 75  GLN C C   1 
ATOM   2704 O O   . GLN B 2 75  ? 156.331 174.962 179.402 1.00 57.14  ? 75  GLN C O   1 
ATOM   2705 C CB  . GLN B 2 75  ? 158.390 176.906 179.711 1.00 57.14  ? 75  GLN C CB  1 
ATOM   2706 C CG  . GLN B 2 75  ? 158.395 178.136 180.593 1.00 57.14  ? 75  GLN C CG  1 
ATOM   2707 C CD  . GLN B 2 75  ? 159.748 178.380 181.215 1.00 57.14  ? 75  GLN C CD  1 
ATOM   2708 O OE1 . GLN B 2 75  ? 160.752 177.835 180.762 1.00 57.14  ? 75  GLN C OE1 1 
ATOM   2709 N NE2 . GLN B 2 75  ? 159.785 179.203 182.257 1.00 57.14  ? 75  GLN C NE2 1 
ATOM   2710 N N   . ASP B 2 76  ? 157.915 173.375 179.499 1.00 58.79  ? 76  ASP C N   1 
ATOM   2711 C CA  . ASP B 2 76  ? 157.064 172.361 178.895 1.00 58.79  ? 76  ASP C CA  1 
ATOM   2712 C C   . ASP B 2 76  ? 156.109 171.726 179.896 1.00 58.79  ? 76  ASP C C   1 
ATOM   2713 O O   . ASP B 2 76  ? 155.313 170.864 179.508 1.00 58.79  ? 76  ASP C O   1 
ATOM   2714 C CB  . ASP B 2 76  ? 157.926 171.280 178.237 1.00 58.79  ? 76  ASP C CB  1 
ATOM   2715 C CG  . ASP B 2 76  ? 159.029 170.774 179.150 1.00 58.79  ? 76  ASP C CG  1 
ATOM   2716 O OD1 . ASP B 2 76  ? 159.166 171.301 180.273 1.00 58.79  ? 76  ASP C OD1 1 
ATOM   2717 O OD2 . ASP B 2 76  ? 159.761 169.849 178.742 1.00 58.79  ? 76  ASP C OD2 1 
ATOM   2718 N N   . GLY B 2 77  ? 156.161 172.135 181.162 1.00 60.80  ? 77  GLY C N   1 
ATOM   2719 C CA  . GLY B 2 77  ? 155.376 171.508 182.202 1.00 60.80  ? 77  GLY C CA  1 
ATOM   2720 C C   . GLY B 2 77  ? 155.948 170.212 182.722 1.00 60.80  ? 77  GLY C C   1 
ATOM   2721 O O   . GLY B 2 77  ? 155.235 169.468 183.404 1.00 60.80  ? 77  GLY C O   1 
ATOM   2722 N N   . LYS B 2 78  ? 157.209 169.917 182.420 1.00 57.29  ? 78  LYS C N   1 
ATOM   2723 C CA  . LYS B 2 78  ? 157.839 168.659 182.791 1.00 57.29  ? 78  LYS C CA  1 
ATOM   2724 C C   . LYS B 2 78  ? 159.044 168.939 183.677 1.00 57.29  ? 78  LYS C C   1 
ATOM   2725 O O   . LYS B 2 78  ? 159.881 169.786 183.346 1.00 57.29  ? 78  LYS C O   1 
ATOM   2726 C CB  . LYS B 2 78  ? 158.255 167.874 181.547 1.00 57.29  ? 78  LYS C CB  1 
ATOM   2727 C CG  . LYS B 2 78  ? 157.100 167.607 180.599 1.00 57.29  ? 78  LYS C CG  1 
ATOM   2728 C CD  . LYS B 2 78  ? 156.028 166.761 181.264 1.00 57.29  ? 78  LYS C CD  1 
ATOM   2729 C CE  . LYS B 2 78  ? 154.919 166.409 180.290 1.00 57.29  ? 78  LYS C CE  1 
ATOM   2730 N NZ  . LYS B 2 78  ? 154.117 167.605 179.917 1.00 57.29  ? 78  LYS C NZ  1 
ATOM   2731 N N   . LEU B 2 79  ? 159.125 168.227 184.795 1.00 56.73  ? 79  LEU C N   1 
ATOM   2732 C CA  . LEU B 2 79  ? 160.203 168.366 185.770 1.00 56.73  ? 79  LEU C CA  1 
ATOM   2733 C C   . LEU B 2 79  ? 160.960 167.040 185.772 1.00 56.73  ? 79  LEU C C   1 
ATOM   2734 O O   . LEU B 2 79  ? 160.652 166.132 186.545 1.00 56.73  ? 79  LEU C O   1 
ATOM   2735 C CB  . LEU B 2 79  ? 159.640 168.710 187.144 1.00 56.73  ? 79  LEU C CB  1 
ATOM   2736 C CG  . LEU B 2 79  ? 160.590 169.093 188.275 1.00 56.73  ? 79  LEU C CG  1 
ATOM   2737 C CD1 . LEU B 2 79  ? 161.288 170.403 187.973 1.00 56.73  ? 79  LEU C CD1 1 
ATOM   2738 C CD2 . LEU B 2 79  ? 159.834 169.185 189.590 1.00 56.73  ? 79  LEU C CD2 1 
ATOM   2739 N N   . ILE B 2 80  ? 161.952 166.936 184.894 1.00 52.98  ? 80  ILE C N   1 
ATOM   2740 C CA  . ILE B 2 80  ? 162.635 165.676 184.625 1.00 52.98  ? 80  ILE C CA  1 
ATOM   2741 C C   . ILE B 2 80  ? 163.726 165.451 185.660 1.00 52.98  ? 80  ILE C C   1 
ATOM   2742 O O   . ILE B 2 80  ? 164.575 166.322 185.882 1.00 52.98  ? 80  ILE C O   1 
ATOM   2743 C CB  . ILE B 2 80  ? 163.223 165.667 183.206 1.00 52.98  ? 80  ILE C CB  1 
ATOM   2744 C CG1 . ILE B 2 80  ? 162.117 165.810 182.163 1.00 52.98  ? 80  ILE C CG1 1 
ATOM   2745 C CG2 . ILE B 2 80  ? 164.028 164.410 182.966 1.00 52.98  ? 80  ILE C CG2 1 
ATOM   2746 C CD1 . ILE B 2 80  ? 162.641 166.069 180.772 1.00 52.98  ? 80  ILE C CD1 1 
ATOM   2747 N N   . ILE B 2 81  ? 163.708 164.278 186.288 1.00 56.65  ? 81  ILE C N   1 
ATOM   2748 C CA  . ILE B 2 81  ? 164.789 163.829 187.155 1.00 56.65  ? 81  ILE C CA  1 
ATOM   2749 C C   . ILE B 2 81  ? 165.698 162.925 186.336 1.00 56.65  ? 81  ILE C C   1 
ATOM   2750 O O   . ILE B 2 81  ? 165.279 161.849 185.892 1.00 56.65  ? 81  ILE C O   1 
ATOM   2751 C CB  . ILE B 2 81  ? 164.247 163.095 188.391 1.00 56.65  ? 81  ILE C CB  1 
ATOM   2752 C CG1 . ILE B 2 81  ? 163.136 163.910 189.049 1.00 56.65  ? 81  ILE C CG1 1 
ATOM   2753 C CG2 . ILE B 2 81  ? 165.365 162.832 189.383 1.00 56.65  ? 81  ILE C CG2 1 
ATOM   2754 C CD1 . ILE B 2 81  ? 162.422 163.171 190.152 1.00 56.65  ? 81  ILE C CD1 1 
ATOM   2755 N N   . TRP B 2 82  ? 166.942 163.352 186.148 1.00 53.07  ? 82  TRP C N   1 
ATOM   2756 C CA  . TRP B 2 82  ? 167.886 162.685 185.264 1.00 53.07  ? 82  TRP C CA  1 
ATOM   2757 C C   . TRP B 2 82  ? 168.746 161.698 186.036 1.00 53.07  ? 82  TRP C C   1 
ATOM   2758 O O   . TRP B 2 82  ? 169.105 161.940 187.192 1.00 53.07  ? 82  TRP C O   1 
ATOM   2759 C CB  . TRP B 2 82  ? 168.809 163.693 184.577 1.00 53.07  ? 82  TRP C CB  1 
ATOM   2760 C CG  . TRP B 2 82  ? 168.130 164.679 183.695 1.00 53.07  ? 82  TRP C CG  1 
ATOM   2761 C CD1 . TRP B 2 82  ? 167.688 165.920 184.041 1.00 53.07  ? 82  TRP C CD1 1 
ATOM   2762 C CD2 . TRP B 2 82  ? 167.857 164.530 182.299 1.00 53.07  ? 82  TRP C CD2 1 
ATOM   2763 N NE1 . TRP B 2 82  ? 167.132 166.544 182.953 1.00 53.07  ? 82  TRP C NE1 1 
ATOM   2764 C CE2 . TRP B 2 82  ? 167.226 165.711 181.869 1.00 53.07  ? 82  TRP C CE2 1 
ATOM   2765 C CE3 . TRP B 2 82  ? 168.072 163.505 181.374 1.00 53.07  ? 82  TRP C CE3 1 
ATOM   2766 C CZ2 . TRP B 2 82  ? 166.810 165.897 180.556 1.00 53.07  ? 82  TRP C CZ2 1 
ATOM   2767 C CZ3 . TRP B 2 82  ? 167.659 163.693 180.071 1.00 53.07  ? 82  TRP C CZ3 1 
ATOM   2768 C CH2 . TRP B 2 82  ? 167.035 164.879 179.675 1.00 53.07  ? 82  TRP C CH2 1 
ATOM   2769 N N   . ASP B 2 83  ? 169.074 160.584 185.388 1.00 58.59  ? 83  ASP C N   1 
ATOM   2770 C CA  . ASP B 2 83  ? 170.195 159.755 185.813 1.00 58.59  ? 83  ASP C CA  1 
ATOM   2771 C C   . ASP B 2 83  ? 171.423 160.238 185.051 1.00 58.59  ? 83  ASP C C   1 
ATOM   2772 O O   . ASP B 2 83  ? 171.527 160.035 183.837 1.00 58.59  ? 83  ASP C O   1 
ATOM   2773 C CB  . ASP B 2 83  ? 169.910 158.279 185.556 1.00 58.59  ? 83  ASP C CB  1 
ATOM   2774 C CG  . ASP B 2 83  ? 170.889 157.365 186.266 1.00 58.59  ? 83  ASP C CG  1 
ATOM   2775 O OD1 . ASP B 2 83  ? 172.053 157.273 185.824 1.00 58.59  ? 83  ASP C OD1 1 
ATOM   2776 O OD2 . ASP B 2 83  ? 170.493 156.741 187.272 1.00 58.59  ? 83  ASP C OD2 1 
ATOM   2777 N N   . SER B 2 84  ? 172.350 160.885 185.759 1.00 54.75  ? 84  SER C N   1 
ATOM   2778 C CA  . SER B 2 84  ? 173.368 161.686 185.087 1.00 54.75  ? 84  SER C CA  1 
ATOM   2779 C C   . SER B 2 84  ? 174.421 160.823 184.401 1.00 54.75  ? 84  SER C C   1 
ATOM   2780 O O   . SER B 2 84  ? 174.888 161.166 183.309 1.00 54.75  ? 84  SER C O   1 
ATOM   2781 C CB  . SER B 2 84  ? 174.022 162.636 186.087 1.00 54.75  ? 84  SER C CB  1 
ATOM   2782 O OG  . SER B 2 84  ? 175.284 163.073 185.625 1.00 54.75  ? 84  SER C OG  1 
ATOM   2783 N N   . TYR B 2 85  ? 174.818 159.710 185.021 1.00 58.94  ? 85  TYR C N   1 
ATOM   2784 C CA  . TYR B 2 85  ? 175.878 158.891 184.437 1.00 58.94  ? 85  TYR C CA  1 
ATOM   2785 C C   . TYR B 2 85  ? 175.388 158.139 183.207 1.00 58.94  ? 85  TYR C C   1 
ATOM   2786 O O   . TYR B 2 85  ? 176.073 158.096 182.178 1.00 58.94  ? 85  TYR C O   1 
ATOM   2787 C CB  . TYR B 2 85  ? 176.431 157.911 185.470 1.00 58.94  ? 85  TYR C CB  1 
ATOM   2788 C CG  . TYR B 2 85  ? 177.266 158.570 186.532 1.00 58.94  ? 85  TYR C CG  1 
ATOM   2789 C CD1 . TYR B 2 85  ? 178.450 159.209 186.205 1.00 58.94  ? 85  TYR C CD1 1 
ATOM   2790 C CD2 . TYR B 2 85  ? 176.896 158.515 187.866 1.00 58.94  ? 85  TYR C CD2 1 
ATOM   2791 C CE1 . TYR B 2 85  ? 179.221 159.812 187.169 1.00 58.94  ? 85  TYR C CE1 1 
ATOM   2792 C CE2 . TYR B 2 85  ? 177.667 159.109 188.844 1.00 58.94  ? 85  TYR C CE2 1 
ATOM   2793 C CZ  . TYR B 2 85  ? 178.831 159.754 188.490 1.00 58.94  ? 85  TYR C CZ  1 
ATOM   2794 O OH  . TYR B 2 85  ? 179.608 160.349 189.456 1.00 58.94  ? 85  TYR C OH  1 
ATOM   2795 N N   . THR B 2 86  ? 174.206 157.544 183.292 1.00 60.37  ? 86  THR C N   1 
ATOM   2796 C CA  . THR B 2 86  ? 173.664 156.754 182.198 1.00 60.37  ? 86  THR C CA  1 
ATOM   2797 C C   . THR B 2 86  ? 172.890 157.592 181.191 1.00 60.37  ? 86  THR C C   1 
ATOM   2798 O O   . THR B 2 86  ? 172.318 157.019 180.256 1.00 60.37  ? 86  THR C O   1 
ATOM   2799 C CB  . THR B 2 86  ? 172.750 155.650 182.744 1.00 60.37  ? 86  THR C CB  1 
ATOM   2800 O OG1 . THR B 2 86  ? 171.631 156.241 183.417 1.00 60.37  ? 86  THR C OG1 1 
ATOM   2801 C CG2 . THR B 2 86  ? 173.507 154.769 183.723 1.00 60.37  ? 86  THR C CG2 1 
ATOM   2802 N N   . THR B 2 87  ? 172.806 158.915 181.403 1.00 56.72  ? 87  THR C N   1 
ATOM   2803 C CA  . THR B 2 87  ? 172.092 159.909 180.592 1.00 56.72  ? 87  THR C CA  1 
ATOM   2804 C C   . THR B 2 87  ? 170.573 159.685 180.650 1.00 56.72  ? 87  THR C C   1 
ATOM   2805 O O   . THR B 2 87  ? 169.796 160.453 180.066 1.00 56.72  ? 87  THR C O   1 
ATOM   2806 C CB  . THR B 2 87  ? 172.640 159.924 179.150 1.00 56.72  ? 87  THR C CB  1 
ATOM   2807 O OG1 . THR B 2 87  ? 174.070 159.952 179.209 1.00 56.72  ? 87  THR C OG1 1 
ATOM   2808 C CG2 . THR B 2 87  ? 172.245 161.181 178.372 1.00 56.72  ? 87  THR C CG2 1 
ATOM   2809 N N   . ASN B 2 88  ? 170.121 158.688 181.406 1.00 59.22  ? 88  ASN C N   1 
ATOM   2810 C CA  . ASN B 2 88  ? 168.723 158.311 181.515 1.00 59.22  ? 88  ASN C CA  1 
ATOM   2811 C C   . ASN B 2 88  ? 167.947 159.327 182.347 1.00 59.22  ? 88  ASN C C   1 
ATOM   2812 O O   . ASN B 2 88  ? 168.504 160.270 182.914 1.00 59.22  ? 88  ASN C O   1 
ATOM   2813 C CB  . ASN B 2 88  ? 168.595 156.929 182.153 1.00 59.22  ? 88  ASN C CB  1 
ATOM   2814 C CG  . ASN B 2 88  ? 168.900 155.810 181.185 1.00 59.22  ? 88  ASN C CG  1 
ATOM   2815 O OD1 . ASN B 2 88  ? 169.443 156.038 180.105 1.00 59.22  ? 88  ASN C OD1 1 
ATOM   2816 N ND2 . ASN B 2 88  ? 168.553 154.588 181.569 1.00 59.22  ? 88  ASN C ND2 1 
ATOM   2817 N N   . LYS B 2 89  ? 166.636 159.119 182.409 1.00 62.56  ? 89  LYS C N   1 
ATOM   2818 C CA  . LYS B 2 89  ? 165.743 159.931 183.220 1.00 62.56  ? 89  LYS C CA  1 
ATOM   2819 C C   . LYS B 2 89  ? 164.842 159.016 184.037 1.00 62.56  ? 89  LYS C C   1 
ATOM   2820 O O   . LYS B 2 89  ? 164.294 158.044 183.508 1.00 62.56  ? 89  LYS C O   1 
ATOM   2821 C CB  . LYS B 2 89  ? 164.925 160.874 182.340 1.00 62.56  ? 89  LYS C CB  1 
ATOM   2822 C CG  . LYS B 2 89  ? 164.393 160.235 181.078 1.00 62.56  ? 89  LYS C CG  1 
ATOM   2823 C CD  . LYS B 2 89  ? 163.438 161.165 180.371 1.00 62.56  ? 89  LYS C CD  1 
ATOM   2824 C CE  . LYS B 2 89  ? 164.189 162.376 179.857 1.00 62.56  ? 89  LYS C CE  1 
ATOM   2825 N NZ  . LYS B 2 89  ? 165.145 161.992 178.784 1.00 62.56  ? 89  LYS C NZ  1 
ATOM   2826 N N   . VAL B 2 90  ? 164.700 159.323 185.325 1.00 64.09  ? 90  VAL C N   1 
ATOM   2827 C CA  . VAL B 2 90  ? 163.978 158.432 186.226 1.00 64.09  ? 90  VAL C CA  1 
ATOM   2828 C C   . VAL B 2 90  ? 162.495 158.783 186.265 1.00 64.09  ? 90  VAL C C   1 
ATOM   2829 O O   . VAL B 2 90  ? 161.632 157.911 186.111 1.00 64.09  ? 90  VAL C O   1 
ATOM   2830 C CB  . VAL B 2 90  ? 164.607 158.476 187.630 1.00 64.09  ? 90  VAL C CB  1 
ATOM   2831 C CG1 . VAL B 2 90  ? 163.866 157.544 188.573 1.00 64.09  ? 90  VAL C CG1 1 
ATOM   2832 C CG2 . VAL B 2 90  ? 166.081 158.116 187.560 1.00 64.09  ? 90  VAL C CG2 1 
ATOM   2833 N N   . HIS B 2 91  ? 162.176 160.059 186.467 1.00 62.18  ? 91  HIS C N   1 
ATOM   2834 C CA  . HIS B 2 91  ? 160.797 160.514 186.543 1.00 62.18  ? 91  HIS C CA  1 
ATOM   2835 C C   . HIS B 2 91  ? 160.596 161.718 185.636 1.00 62.18  ? 91  HIS C C   1 
ATOM   2836 O O   . HIS B 2 91  ? 161.520 162.500 185.397 1.00 62.18  ? 91  HIS C O   1 
ATOM   2837 C CB  . HIS B 2 91  ? 160.398 160.891 187.976 1.00 62.18  ? 91  HIS C CB  1 
ATOM   2838 C CG  . HIS B 2 91  ? 160.482 159.759 188.950 1.00 62.18  ? 91  HIS C CG  1 
ATOM   2839 N ND1 . HIS B 2 91  ? 161.421 159.712 189.958 1.00 62.18  ? 91  HIS C ND1 1 
ATOM   2840 C CD2 . HIS B 2 91  ? 159.729 158.642 189.086 1.00 62.18  ? 91  HIS C CD2 1 
ATOM   2841 C CE1 . HIS B 2 91  ? 161.250 158.611 190.666 1.00 62.18  ? 91  HIS C CE1 1 
ATOM   2842 N NE2 . HIS B 2 91  ? 160.231 157.942 190.156 1.00 62.18  ? 91  HIS C NE2 1 
ATOM   2843 N N   . ALA B 2 92  ? 159.368 161.861 185.137 1.00 61.25  ? 92  ALA C N   1 
ATOM   2844 C CA  . ALA B 2 92  ? 158.948 163.012 184.338 1.00 61.25  ? 92  ALA C CA  1 
ATOM   2845 C C   . ALA B 2 92  ? 157.716 163.594 185.025 1.00 61.25  ? 92  ALA C C   1 
ATOM   2846 O O   . ALA B 2 92  ? 156.584 163.203 184.727 1.00 61.25  ? 92  ALA C O   1 
ATOM   2847 C CB  . ALA B 2 92  ? 158.663 162.616 182.894 1.00 61.25  ? 92  ALA C CB  1 
ATOM   2848 N N   . ILE B 2 93  ? 157.942 164.523 185.946 1.00 63.61  ? 93  ILE C N   1 
ATOM   2849 C CA  . ILE B 2 93  ? 156.873 165.068 186.779 1.00 63.61  ? 93  ILE C CA  1 
ATOM   2850 C C   . ILE B 2 93  ? 156.088 166.122 186.009 1.00 63.61  ? 93  ILE C C   1 
ATOM   2851 O O   . ILE B 2 93  ? 156.665 167.124 185.563 1.00 63.61  ? 93  ILE C O   1 
ATOM   2852 C CB  . ILE B 2 93  ? 157.435 165.653 188.082 1.00 63.61  ? 93  ILE C CB  1 
ATOM   2853 C CG1 . ILE B 2 93  ? 158.428 164.677 188.714 1.00 63.61  ? 93  ILE C CG1 1 
ATOM   2854 C CG2 . ILE B 2 93  ? 156.305 165.984 189.045 1.00 63.61  ? 93  ILE C CG2 1 
ATOM   2855 C CD1 . ILE B 2 93  ? 159.383 165.321 189.688 1.00 63.61  ? 93  ILE C CD1 1 
ATOM   2856 N N   . PRO B 2 94  ? 154.782 165.941 185.825 1.00 64.68  ? 94  PRO C N   1 
ATOM   2857 C CA  . PRO B 2 94  ? 153.970 167.009 185.237 1.00 64.68  ? 94  PRO C CA  1 
ATOM   2858 C C   . PRO B 2 94  ? 153.765 168.142 186.228 1.00 64.68  ? 94  PRO C C   1 
ATOM   2859 O O   . PRO B 2 94  ? 153.837 167.956 187.445 1.00 64.68  ? 94  PRO C O   1 
ATOM   2860 C CB  . PRO B 2 94  ? 152.648 166.310 184.908 1.00 64.68  ? 94  PRO C CB  1 
ATOM   2861 C CG  . PRO B 2 94  ? 152.567 165.196 185.893 1.00 64.68  ? 94  PRO C CG  1 
ATOM   2862 C CD  . PRO B 2 94  ? 153.982 164.748 186.151 1.00 64.68  ? 94  PRO C CD  1 
ATOM   2863 N N   . LEU B 2 95  ? 153.507 169.330 185.689 1.00 65.80  ? 95  LEU C N   1 
ATOM   2864 C CA  . LEU B 2 95  ? 153.276 170.522 186.493 1.00 65.80  ? 95  LEU C CA  1 
ATOM   2865 C C   . LEU B 2 95  ? 151.880 171.062 186.218 1.00 65.80  ? 95  LEU C C   1 
ATOM   2866 O O   . LEU B 2 95  ? 151.410 171.037 185.077 1.00 65.80  ? 95  LEU C O   1 
ATOM   2867 C CB  . LEU B 2 95  ? 154.318 171.608 186.199 1.00 65.80  ? 95  LEU C CB  1 
ATOM   2868 C CG  . LEU B 2 95  ? 155.794 171.208 186.210 1.00 65.80  ? 95  LEU C CG  1 
ATOM   2869 C CD1 . LEU B 2 95  ? 156.680 172.429 186.012 1.00 65.80  ? 95  LEU C CD1 1 
ATOM   2870 C CD2 . LEU B 2 95  ? 156.157 170.479 187.493 1.00 65.80  ? 95  LEU C CD2 1 
ATOM   2871 N N   . ARG B 2 96  ? 151.215 171.538 187.274 1.00 74.01  ? 96  ARG C N   1 
ATOM   2872 C CA  . ARG B 2 96  ? 149.918 172.182 187.093 1.00 74.01  ? 96  ARG C CA  1 
ATOM   2873 C C   . ARG B 2 96  ? 150.061 173.507 186.355 1.00 74.01  ? 96  ARG C C   1 
ATOM   2874 O O   . ARG B 2 96  ? 149.171 173.899 185.592 1.00 74.01  ? 96  ARG C O   1 
ATOM   2875 C CB  . ARG B 2 96  ? 149.233 172.392 188.443 1.00 74.01  ? 96  ARG C CB  1 
ATOM   2876 C CG  . ARG B 2 96  ? 148.722 171.118 189.093 1.00 74.01  ? 96  ARG C CG  1 
ATOM   2877 C CD  . ARG B 2 96  ? 147.915 171.434 190.344 1.00 74.01  ? 96  ARG C CD  1 
ATOM   2878 N NE  . ARG B 2 96  ? 147.366 170.236 190.969 1.00 74.01  ? 96  ARG C NE  1 
ATOM   2879 C CZ  . ARG B 2 96  ? 147.955 169.566 191.950 1.00 74.01  ? 96  ARG C CZ  1 
ATOM   2880 N NH1 . ARG B 2 96  ? 149.116 169.954 192.451 1.00 74.01  ? 96  ARG C NH1 1 
ATOM   2881 N NH2 . ARG B 2 96  ? 147.362 168.483 192.444 1.00 74.01  ? 96  ARG C NH2 1 
ATOM   2882 N N   . SER B 2 97  ? 151.169 174.211 186.573 1.00 65.32  ? 97  SER C N   1 
ATOM   2883 C CA  . SER B 2 97  ? 151.454 175.475 185.910 1.00 65.32  ? 97  SER C CA  1 
ATOM   2884 C C   . SER B 2 97  ? 152.694 175.319 185.046 1.00 65.32  ? 97  SER C C   1 
ATOM   2885 O O   . SER B 2 97  ? 153.708 174.783 185.501 1.00 65.32  ? 97  SER C O   1 
ATOM   2886 C CB  . SER B 2 97  ? 151.664 176.598 186.926 1.00 65.32  ? 97  SER C CB  1 
ATOM   2887 O OG  . SER B 2 97  ? 152.043 177.800 186.278 1.00 65.32  ? 97  SER C OG  1 
ATOM   2888 N N   . SER B 2 98  ? 152.615 175.798 183.806 1.00 63.27  ? 98  SER C N   1 
ATOM   2889 C CA  . SER B 2 98  ? 153.729 175.669 182.877 1.00 63.27  ? 98  SER C CA  1 
ATOM   2890 C C   . SER B 2 98  ? 154.808 176.722 183.087 1.00 63.27  ? 98  SER C C   1 
ATOM   2891 O O   . SER B 2 98  ? 155.851 176.652 182.429 1.00 63.27  ? 98  SER C O   1 
ATOM   2892 C CB  . SER B 2 98  ? 153.220 175.737 181.436 1.00 63.27  ? 98  SER C CB  1 
ATOM   2893 O OG  . SER B 2 98  ? 152.566 176.967 181.184 1.00 63.27  ? 98  SER C OG  1 
ATOM   2894 N N   . TRP B 2 99  ? 154.591 177.690 183.974 1.00 58.20  ? 99  TRP C N   1 
ATOM   2895 C CA  . TRP B 2 99  ? 155.570 178.749 184.217 1.00 58.20  ? 99  TRP C CA  1 
ATOM   2896 C C   . TRP B 2 99  ? 156.453 178.355 185.389 1.00 58.20  ? 99  TRP C C   1 
ATOM   2897 O O   . TRP B 2 99  ? 156.078 178.481 186.555 1.00 58.20  ? 99  TRP C O   1 
ATOM   2898 C CB  . TRP B 2 99  ? 154.874 180.080 184.460 1.00 58.20  ? 99  TRP C CB  1 
ATOM   2899 C CG  . TRP B 2 99  ? 153.820 180.356 183.450 1.00 58.20  ? 99  TRP C CG  1 
ATOM   2900 C CD1 . TRP B 2 99  ? 152.470 180.352 183.644 1.00 58.20  ? 99  TRP C CD1 1 
ATOM   2901 C CD2 . TRP B 2 99  ? 154.026 180.633 182.062 1.00 58.20  ? 99  TRP C CD2 1 
ATOM   2902 N NE1 . TRP B 2 99  ? 151.824 180.635 182.467 1.00 58.20  ? 99  TRP C NE1 1 
ATOM   2903 C CE2 . TRP B 2 99  ? 152.758 180.808 181.481 1.00 58.20  ? 99  TRP C CE2 1 
ATOM   2904 C CE3 . TRP B 2 99  ? 155.162 180.760 181.258 1.00 58.20  ? 99  TRP C CE3 1 
ATOM   2905 C CZ2 . TRP B 2 99  ? 152.595 181.101 180.136 1.00 58.20  ? 99  TRP C CZ2 1 
ATOM   2906 C CZ3 . TRP B 2 99  ? 154.997 181.050 179.923 1.00 58.20  ? 99  TRP C CZ3 1 
ATOM   2907 C CH2 . TRP B 2 99  ? 153.724 181.217 179.373 1.00 58.20  ? 99  TRP C CH2 1 
ATOM   2908 N N   . VAL B 2 100 ? 157.651 177.878 185.076 1.00 55.28  ? 100 VAL C N   1 
ATOM   2909 C CA  . VAL B 2 100 ? 158.616 177.459 186.082 1.00 55.28  ? 100 VAL C CA  1 
ATOM   2910 C C   . VAL B 2 100 ? 159.950 178.136 185.788 1.00 55.28  ? 100 VAL C C   1 
ATOM   2911 O O   . VAL B 2 100 ? 160.340 178.298 184.626 1.00 55.28  ? 100 VAL C O   1 
ATOM   2912 C CB  . VAL B 2 100 ? 158.740 175.914 186.144 1.00 55.28  ? 100 VAL C CB  1 
ATOM   2913 C CG1 . VAL B 2 100 ? 159.291 175.340 184.859 1.00 55.28  ? 100 VAL C CG1 1 
ATOM   2914 C CG2 . VAL B 2 100 ? 159.585 175.475 187.326 1.00 55.28  ? 100 VAL C CG2 1 
ATOM   2915 N N   . MET B 2 101 ? 160.600 178.626 186.842 1.00 53.89  ? 101 MET C N   1 
ATOM   2916 C CA  . MET B 2 101 ? 161.960 179.132 186.742 1.00 53.89  ? 101 MET C CA  1 
ATOM   2917 C C   . MET B 2 101 ? 162.790 178.768 187.966 1.00 53.89  ? 101 MET C C   1 
ATOM   2918 O O   . MET B 2 101 ? 163.917 179.258 188.105 1.00 53.89  ? 101 MET C O   1 
ATOM   2919 C CB  . MET B 2 101 ? 161.968 180.649 186.536 1.00 53.89  ? 101 MET C CB  1 
ATOM   2920 C CG  . MET B 2 101 ? 160.995 181.408 187.413 1.00 53.89  ? 101 MET C CG  1 
ATOM   2921 S SD  . MET B 2 101 ? 160.601 183.026 186.727 1.00 53.89  ? 101 MET C SD  1 
ATOM   2922 C CE  . MET B 2 101 ? 162.180 183.852 186.853 1.00 53.89  ? 101 MET C CE  1 
ATOM   2923 N N   . THR B 2 102 ? 162.263 177.934 188.857 1.00 50.47  ? 102 THR C N   1 
ATOM   2924 C CA  . THR B 2 102 ? 163.024 177.444 189.993 1.00 50.47  ? 102 THR C CA  1 
ATOM   2925 C C   . THR B 2 102 ? 162.690 175.984 190.252 1.00 50.47  ? 102 THR C C   1 
ATOM   2926 O O   . THR B 2 102 ? 161.568 175.525 190.017 1.00 50.47  ? 102 THR C O   1 
ATOM   2927 C CB  . THR B 2 102 ? 162.777 178.276 191.257 1.00 50.47  ? 102 THR C CB  1 
ATOM   2928 O OG1 . THR B 2 102 ? 163.570 177.753 192.329 1.00 50.47  ? 102 THR C OG1 1 
ATOM   2929 C CG2 . THR B 2 102 ? 161.312 178.270 191.650 1.00 50.47  ? 102 THR C CG2 1 
ATOM   2930 N N   . CYS B 2 103 ? 163.696 175.260 190.731 1.00 49.24  ? 103 CYS C N   1 
ATOM   2931 C CA  . CYS B 2 103 ? 163.570 173.859 191.093 1.00 49.24  ? 103 CYS C CA  1 
ATOM   2932 C C   . CYS B 2 103 ? 164.739 173.508 191.998 1.00 49.24  ? 103 CYS C C   1 
ATOM   2933 O O   . CYS B 2 103 ? 165.818 174.097 191.893 1.00 49.24  ? 103 CYS C O   1 
ATOM   2934 C CB  . CYS B 2 103 ? 163.541 172.955 189.856 1.00 49.24  ? 103 CYS C CB  1 
ATOM   2935 S SG  . CYS B 2 103 ? 165.130 172.760 189.022 1.00 49.24  ? 103 CYS C SG  1 
ATOM   2936 N N   . ALA B 2 104 ? 164.511 172.558 192.897 1.00 50.19  ? 104 ALA C N   1 
ATOM   2937 C CA  . ALA B 2 104 ? 165.574 172.120 193.784 1.00 50.19  ? 104 ALA C CA  1 
ATOM   2938 C C   . ALA B 2 104 ? 165.403 170.642 194.084 1.00 50.19  ? 104 ALA C C   1 
ATOM   2939 O O   . ALA B 2 104 ? 164.307 170.088 193.986 1.00 50.19  ? 104 ALA C O   1 
ATOM   2940 C CB  . ALA B 2 104 ? 165.599 172.929 195.080 1.00 50.19  ? 104 ALA C CB  1 
ATOM   2941 N N   . TYR B 2 105 ? 166.512 170.009 194.443 1.00 57.29  ? 105 TYR C N   1 
ATOM   2942 C CA  . TYR B 2 105 ? 166.528 168.616 194.855 1.00 57.29  ? 105 TYR C CA  1 
ATOM   2943 C C   . TYR B 2 105 ? 166.977 168.577 196.306 1.00 57.29  ? 105 TYR C C   1 
ATOM   2944 O O   . TYR B 2 105 ? 168.052 169.089 196.637 1.00 57.29  ? 105 TYR C O   1 
ATOM   2945 C CB  . TYR B 2 105 ? 167.461 167.793 193.964 1.00 57.29  ? 105 TYR C CB  1 
ATOM   2946 C CG  . TYR B 2 105 ? 167.271 166.302 194.079 1.00 57.29  ? 105 TYR C CG  1 
ATOM   2947 C CD1 . TYR B 2 105 ? 166.202 165.676 193.455 1.00 57.29  ? 105 TYR C CD1 1 
ATOM   2948 C CD2 . TYR B 2 105 ? 168.157 165.520 194.803 1.00 57.29  ? 105 TYR C CD2 1 
ATOM   2949 C CE1 . TYR B 2 105 ? 166.018 164.315 193.549 1.00 57.29  ? 105 TYR C CE1 1 
ATOM   2950 C CE2 . TYR B 2 105 ? 167.982 164.154 194.904 1.00 57.29  ? 105 TYR C CE2 1 
ATOM   2951 C CZ  . TYR B 2 105 ? 166.909 163.559 194.276 1.00 57.29  ? 105 TYR C CZ  1 
ATOM   2952 O OH  . TYR B 2 105 ? 166.723 162.200 194.373 1.00 57.29  ? 105 TYR C OH  1 
ATOM   2953 N N   . ALA B 2 106 ? 166.146 167.998 197.165 1.00 57.00  ? 106 ALA C N   1 
ATOM   2954 C CA  . ALA B 2 106 ? 166.421 168.008 198.593 1.00 57.00  ? 106 ALA C CA  1 
ATOM   2955 C C   . ALA B 2 106 ? 167.648 167.153 198.900 1.00 57.00  ? 106 ALA C C   1 
ATOM   2956 O O   . ALA B 2 106 ? 167.967 166.234 198.139 1.00 57.00  ? 106 ALA C O   1 
ATOM   2957 C CB  . ALA B 2 106 ? 165.212 167.491 199.374 1.00 57.00  ? 106 ALA C CB  1 
ATOM   2958 N N   . PRO B 2 107 ? 168.378 167.457 199.978 1.00 59.81  ? 107 PRO C N   1 
ATOM   2959 C CA  . PRO B 2 107 ? 169.496 166.584 200.371 1.00 59.81  ? 107 PRO C CA  1 
ATOM   2960 C C   . PRO B 2 107 ? 169.075 165.160 200.692 1.00 59.81  ? 107 PRO C C   1 
ATOM   2961 O O   . PRO B 2 107 ? 169.836 164.224 200.420 1.00 59.81  ? 107 PRO C O   1 
ATOM   2962 C CB  . PRO B 2 107 ? 170.080 167.293 201.602 1.00 59.81  ? 107 PRO C CB  1 
ATOM   2963 C CG  . PRO B 2 107 ? 169.025 168.234 202.059 1.00 59.81  ? 107 PRO C CG  1 
ATOM   2964 C CD  . PRO B 2 107 ? 168.294 168.652 200.832 1.00 59.81  ? 107 PRO C CD  1 
ATOM   2965 N N   . SER B 2 108 ? 167.879 164.963 201.250 1.00 63.76  ? 108 SER C N   1 
ATOM   2966 C CA  . SER B 2 108 ? 167.374 163.617 201.482 1.00 63.76  ? 108 SER C CA  1 
ATOM   2967 C C   . SER B 2 108 ? 166.923 162.933 200.200 1.00 63.76  ? 108 SER C C   1 
ATOM   2968 O O   . SER B 2 108 ? 166.778 161.706 200.192 1.00 63.76  ? 108 SER C O   1 
ATOM   2969 C CB  . SER B 2 108 ? 166.213 163.650 202.477 1.00 63.76  ? 108 SER C CB  1 
ATOM   2970 O OG  . SER B 2 108 ? 164.999 163.994 201.831 1.00 63.76  ? 108 SER C OG  1 
ATOM   2971 N N   . GLY B 2 109 ? 166.695 163.688 199.129 1.00 64.28  ? 109 GLY C N   1 
ATOM   2972 C CA  . GLY B 2 109 ? 166.273 163.120 197.868 1.00 64.28  ? 109 GLY C CA  1 
ATOM   2973 C C   . GLY B 2 109 ? 164.813 162.749 197.782 1.00 64.28  ? 109 GLY C C   1 
ATOM   2974 O O   . GLY B 2 109 ? 164.396 162.179 196.769 1.00 64.28  ? 109 GLY C O   1 
ATOM   2975 N N   . ASN B 2 110 ? 164.017 163.058 198.805 1.00 71.55  ? 110 ASN C N   1 
ATOM   2976 C CA  . ASN B 2 110 ? 162.620 162.649 198.835 1.00 71.55  ? 110 ASN C CA  1 
ATOM   2977 C C   . ASN B 2 110 ? 161.662 163.722 198.332 1.00 71.55  ? 110 ASN C C   1 
ATOM   2978 O O   . ASN B 2 110 ? 160.528 163.392 197.965 1.00 71.55  ? 110 ASN C O   1 
ATOM   2979 C CB  . ASN B 2 110 ? 162.225 162.245 200.261 1.00 71.55  ? 110 ASN C CB  1 
ATOM   2980 C CG  . ASN B 2 110 ? 161.159 161.167 200.289 1.00 71.55  ? 110 ASN C CG  1 
ATOM   2981 O OD1 . ASN B 2 110 ? 160.566 160.835 199.264 1.00 71.55  ? 110 ASN C OD1 1 
ATOM   2982 N ND2 . ASN B 2 110 ? 160.916 160.608 201.468 1.00 71.55  ? 110 ASN C ND2 1 
ATOM   2983 N N   . TYR B 2 111 ? 162.081 164.985 198.298 1.00 69.47  ? 111 TYR C N   1 
ATOM   2984 C CA  . TYR B 2 111 ? 161.216 166.079 197.886 1.00 69.47  ? 111 TYR C CA  1 
ATOM   2985 C C   . TYR B 2 111 ? 161.938 166.970 196.886 1.00 69.47  ? 111 TYR C C   1 
ATOM   2986 O O   . TYR B 2 111 ? 163.165 167.087 196.893 1.00 69.47  ? 111 TYR C O   1 
ATOM   2987 C CB  . TYR B 2 111 ? 160.741 166.904 199.090 1.00 69.47  ? 111 TYR C CB  1 
ATOM   2988 C CG  . TYR B 2 111 ? 159.908 166.106 200.065 1.00 69.47  ? 111 TYR C CG  1 
ATOM   2989 C CD1 . TYR B 2 111 ? 160.494 165.448 201.136 1.00 69.47  ? 111 TYR C CD1 1 
ATOM   2990 C CD2 . TYR B 2 111 ? 158.532 165.999 199.903 1.00 69.47  ? 111 TYR C CD2 1 
ATOM   2991 C CE1 . TYR B 2 111 ? 159.732 164.713 202.023 1.00 69.47  ? 111 TYR C CE1 1 
ATOM   2992 C CE2 . TYR B 2 111 ? 157.762 165.268 200.786 1.00 69.47  ? 111 TYR C CE2 1 
ATOM   2993 C CZ  . TYR B 2 111 ? 158.367 164.626 201.845 1.00 69.47  ? 111 TYR C CZ  1 
ATOM   2994 O OH  . TYR B 2 111 ? 157.606 163.895 202.728 1.00 69.47  ? 111 TYR C OH  1 
ATOM   2995 N N   . VAL B 2 112 ? 161.152 167.590 196.009 1.00 60.80  ? 112 VAL C N   1 
ATOM   2996 C CA  . VAL B 2 112 ? 161.668 168.497 194.993 1.00 60.80  ? 112 VAL C CA  1 
ATOM   2997 C C   . VAL B 2 112 ? 160.867 169.788 195.031 1.00 60.80  ? 112 VAL C C   1 
ATOM   2998 O O   . VAL B 2 112 ? 159.714 169.815 195.474 1.00 60.80  ? 112 VAL C O   1 
ATOM   2999 C CB  . VAL B 2 112 ? 161.619 167.883 193.580 1.00 60.80  ? 112 VAL C CB  1 
ATOM   3000 C CG1 . VAL B 2 112 ? 162.721 166.855 193.412 1.00 60.80  ? 112 VAL C CG1 1 
ATOM   3001 C CG2 . VAL B 2 112 ? 160.255 167.266 193.328 1.00 60.80  ? 112 VAL C CG2 1 
ATOM   3002 N N   . ALA B 2 113 ? 161.485 170.864 194.555 1.00 56.67  ? 113 ALA C N   1 
ATOM   3003 C CA  . ALA B 2 113 ? 160.853 172.171 194.499 1.00 56.67  ? 113 ALA C CA  1 
ATOM   3004 C C   . ALA B 2 113 ? 160.391 172.477 193.084 1.00 56.67  ? 113 ALA C C   1 
ATOM   3005 O O   . ALA B 2 113 ? 160.975 172.010 192.104 1.00 56.67  ? 113 ALA C O   1 
ATOM   3006 C CB  . ALA B 2 113 ? 161.806 173.271 194.962 1.00 56.67  ? 113 ALA C CB  1 
ATOM   3007 N N   . CYS B 2 114 ? 159.332 173.275 192.992 1.00 61.94  ? 114 CYS C N   1 
ATOM   3008 C CA  . CYS B 2 114 ? 158.840 173.756 191.712 1.00 61.94  ? 114 CYS C CA  1 
ATOM   3009 C C   . CYS B 2 114 ? 158.045 175.029 191.952 1.00 61.94  ? 114 CYS C C   1 
ATOM   3010 O O   . CYS B 2 114 ? 157.141 175.052 192.791 1.00 61.94  ? 114 CYS C O   1 
ATOM   3011 C CB  . CYS B 2 114 ? 157.971 172.708 191.011 1.00 61.94  ? 114 CYS C CB  1 
ATOM   3012 S SG  . CYS B 2 114 ? 157.053 173.347 189.594 1.00 61.94  ? 114 CYS C SG  1 
ATOM   3013 N N   . GLY B 2 115 ? 158.386 176.074 191.213 1.00 57.04  ? 115 GLY C N   1 
ATOM   3014 C CA  . GLY B 2 115 ? 157.690 177.341 191.337 1.00 57.04  ? 115 GLY C CA  1 
ATOM   3015 C C   . GLY B 2 115 ? 158.054 178.235 190.175 1.00 57.04  ? 115 GLY C C   1 
ATOM   3016 O O   . GLY B 2 115 ? 158.963 177.941 189.393 1.00 57.04  ? 115 GLY C O   1 
ATOM   3017 N N   . GLY B 2 116 ? 157.333 179.344 190.078 1.00 54.66  ? 116 GLY C N   1 
ATOM   3018 C CA  . GLY B 2 116 ? 157.548 180.272 188.987 1.00 54.66  ? 116 GLY C CA  1 
ATOM   3019 C C   . GLY B 2 116 ? 156.594 181.444 189.029 1.00 54.66  ? 116 GLY C C   1 
ATOM   3020 O O   . GLY B 2 116 ? 156.388 182.044 190.087 1.00 54.66  ? 116 GLY C O   1 
ATOM   3021 N N   . LEU B 2 117 ? 155.993 181.776 187.887 1.00 53.06  ? 117 LEU C N   1 
ATOM   3022 C CA  . LEU B 2 117 ? 155.098 182.923 187.833 1.00 53.06  ? 117 LEU C CA  1 
ATOM   3023 C C   . LEU B 2 117 ? 153.720 182.617 188.402 1.00 53.06  ? 117 LEU C C   1 
ATOM   3024 O O   . LEU B 2 117 ? 152.904 183.535 188.525 1.00 53.06  ? 117 LEU C O   1 
ATOM   3025 C CB  . LEU B 2 117 ? 154.960 183.434 186.396 1.00 53.06  ? 117 LEU C CB  1 
ATOM   3026 C CG  . LEU B 2 117 ? 156.076 184.317 185.826 1.00 53.06  ? 117 LEU C CG  1 
ATOM   3027 C CD1 . LEU B 2 117 ? 157.277 183.508 185.398 1.00 53.06  ? 117 LEU C CD1 1 
ATOM   3028 C CD2 . LEU B 2 117 ? 155.578 185.152 184.676 1.00 53.06  ? 117 LEU C CD2 1 
ATOM   3029 N N   . ASP B 2 118 ? 153.443 181.362 188.753 1.00 56.94  ? 118 ASP C N   1 
ATOM   3030 C CA  . ASP B 2 118 ? 152.152 180.997 189.318 1.00 56.94  ? 118 ASP C CA  1 
ATOM   3031 C C   . ASP B 2 118 ? 152.019 181.374 190.785 1.00 56.94  ? 118 ASP C C   1 
ATOM   3032 O O   . ASP B 2 118 ? 150.940 181.180 191.356 1.00 56.94  ? 118 ASP C O   1 
ATOM   3033 C CB  . ASP B 2 118 ? 151.917 179.494 189.161 1.00 56.94  ? 118 ASP C CB  1 
ATOM   3034 C CG  . ASP B 2 118 ? 152.980 178.664 189.851 1.00 56.94  ? 118 ASP C CG  1 
ATOM   3035 O OD1 . ASP B 2 118 ? 154.149 179.101 189.880 1.00 56.94  ? 118 ASP C OD1 1 
ATOM   3036 O OD2 . ASP B 2 118 ? 152.647 177.575 190.365 1.00 56.94  ? 118 ASP C OD2 1 
ATOM   3037 N N   . ASN B 2 119 ? 153.092 181.873 191.402 1.00 57.85  ? 119 ASN C N   1 
ATOM   3038 C CA  . ASN B 2 119 ? 153.173 182.329 192.789 1.00 57.85  ? 119 ASN C CA  1 
ATOM   3039 C C   . ASN B 2 119 ? 152.907 181.223 193.801 1.00 57.85  ? 119 ASN C C   1 
ATOM   3040 O O   . ASN B 2 119 ? 152.526 181.518 194.940 1.00 57.85  ? 119 ASN C O   1 
ATOM   3041 C CB  . ASN B 2 119 ? 152.222 183.498 193.070 1.00 57.85  ? 119 ASN C CB  1 
ATOM   3042 C CG  . ASN B 2 119 ? 152.316 184.585 192.027 1.00 57.85  ? 119 ASN C CG  1 
ATOM   3043 O OD1 . ASN B 2 119 ? 153.331 184.725 191.351 1.00 57.85  ? 119 ASN C OD1 1 
ATOM   3044 N ND2 . ASN B 2 119 ? 151.263 185.380 191.907 1.00 57.85  ? 119 ASN C ND2 1 
ATOM   3045 N N   . ILE B 2 120 ? 153.088 179.960 193.423 1.00 60.03  ? 120 ILE C N   1 
ATOM   3046 C CA  . ILE B 2 120 ? 152.842 178.822 194.301 1.00 60.03  ? 120 ILE C CA  1 
ATOM   3047 C C   . ILE B 2 120 ? 154.051 177.899 194.241 1.00 60.03  ? 120 ILE C C   1 
ATOM   3048 O O   . ILE B 2 120 ? 154.507 177.541 193.149 1.00 60.03  ? 120 ILE C O   1 
ATOM   3049 C CB  . ILE B 2 120 ? 151.559 178.061 193.907 1.00 60.03  ? 120 ILE C CB  1 
ATOM   3050 C CG1 . ILE B 2 120 ? 150.326 178.950 194.077 1.00 60.03  ? 120 ILE C CG1 1 
ATOM   3051 C CG2 . ILE B 2 120 ? 151.403 176.795 194.725 1.00 60.03  ? 120 ILE C CG2 1 
ATOM   3052 C CD1 . ILE B 2 120 ? 149.063 178.353 193.503 1.00 60.03  ? 120 ILE C CD1 1 
ATOM   3053 N N   . CYS B 2 121 ? 154.572 177.522 195.407 1.00 59.83  ? 121 CYS C N   1 
ATOM   3054 C CA  . CYS B 2 121 ? 155.636 176.530 195.475 1.00 59.83  ? 121 CYS C CA  1 
ATOM   3055 C C   . CYS B 2 121 ? 155.045 175.128 195.467 1.00 59.83  ? 121 CYS C C   1 
ATOM   3056 O O   . CYS B 2 121 ? 154.078 174.842 196.178 1.00 59.83  ? 121 CYS C O   1 
ATOM   3057 C CB  . CYS B 2 121 ? 156.481 176.727 196.731 1.00 59.83  ? 121 CYS C CB  1 
ATOM   3058 S SG  . CYS B 2 121 ? 158.131 176.015 196.636 1.00 59.83  ? 121 CYS C SG  1 
ATOM   3059 N N   . SER B 2 122 ? 155.638 174.250 194.663 1.00 62.89  ? 122 SER C N   1 
ATOM   3060 C CA  . SER B 2 122 ? 155.165 172.882 194.512 1.00 62.89  ? 122 SER C CA  1 
ATOM   3061 C C   . SER B 2 122 ? 156.202 171.924 195.076 1.00 62.89  ? 122 SER C C   1 
ATOM   3062 O O   . SER B 2 122 ? 157.373 171.968 194.683 1.00 62.89  ? 122 SER C O   1 
ATOM   3063 C CB  . SER B 2 122 ? 154.887 172.559 193.044 1.00 62.89  ? 122 SER C CB  1 
ATOM   3064 O OG  . SER B 2 122 ? 154.110 173.573 192.436 1.00 62.89  ? 122 SER C OG  1 
ATOM   3065 N N   . ILE B 2 123 ? 155.772 171.064 195.997 1.00 66.14  ? 123 ILE C N   1 
ATOM   3066 C CA  . ILE B 2 123 ? 156.624 170.040 196.592 1.00 66.14  ? 123 ILE C CA  1 
ATOM   3067 C C   . ILE B 2 123 ? 156.027 168.679 196.267 1.00 66.14  ? 123 ILE C C   1 
ATOM   3068 O O   . ILE B 2 123 ? 154.858 168.415 196.576 1.00 66.14  ? 123 ILE C O   1 
ATOM   3069 C CB  . ILE B 2 123 ? 156.773 170.230 198.108 1.00 66.14  ? 123 ILE C CB  1 
ATOM   3070 C CG1 . ILE B 2 123 ? 157.108 171.683 198.435 1.00 66.14  ? 123 ILE C CG1 1 
ATOM   3071 C CG2 . ILE B 2 123 ? 157.838 169.302 198.657 1.00 66.14  ? 123 ILE C CG2 1 
ATOM   3072 C CD1 . ILE B 2 123 ? 158.466 172.120 197.922 1.00 66.14  ? 123 ILE C CD1 1 
ATOM   3073 N N   . TYR B 2 124 ? 156.829 167.813 195.655 1.00 69.30  ? 124 TYR C N   1 
ATOM   3074 C CA  . TYR B 2 124 ? 156.390 166.488 195.247 1.00 69.30  ? 124 TYR C CA  1 
ATOM   3075 C C   . TYR B 2 124 ? 157.135 165.421 196.036 1.00 69.30  ? 124 TYR C C   1 
ATOM   3076 O O   . TYR B 2 124 ? 158.331 165.558 196.310 1.00 69.30  ? 124 TYR C O   1 
ATOM   3077 C CB  . TYR B 2 124 ? 156.615 166.272 193.749 1.00 69.30  ? 124 TYR C CB  1 
ATOM   3078 C CG  . TYR B 2 124 ? 156.078 167.383 192.878 1.00 69.30  ? 124 TYR C CG  1 
ATOM   3079 C CD1 . TYR B 2 124 ? 154.748 167.394 192.475 1.00 69.30  ? 124 TYR C CD1 1 
ATOM   3080 C CD2 . TYR B 2 124 ? 156.905 168.411 192.443 1.00 69.30  ? 124 TYR C CD2 1 
ATOM   3081 C CE1 . TYR B 2 124 ? 154.252 168.404 191.675 1.00 69.30  ? 124 TYR C CE1 1 
ATOM   3082 C CE2 . TYR B 2 124 ? 156.419 169.426 191.641 1.00 69.30  ? 124 TYR C CE2 1 
ATOM   3083 C CZ  . TYR B 2 124 ? 155.092 169.417 191.261 1.00 69.30  ? 124 TYR C CZ  1 
ATOM   3084 O OH  . TYR B 2 124 ? 154.602 170.424 190.463 1.00 69.30  ? 124 TYR C OH  1 
ATOM   3085 N N   . ASN B 2 125 ? 156.424 164.355 196.395 1.00 73.97  ? 125 ASN C N   1 
ATOM   3086 C CA  . ASN B 2 125 ? 157.004 163.221 197.105 1.00 73.97  ? 125 ASN C CA  1 
ATOM   3087 C C   . ASN B 2 125 ? 157.501 162.217 196.072 1.00 73.97  ? 125 ASN C C   1 
ATOM   3088 O O   . ASN B 2 125 ? 156.700 161.592 195.369 1.00 73.97  ? 125 ASN C O   1 
ATOM   3089 C CB  . ASN B 2 125 ? 155.981 162.584 198.043 1.00 73.97  ? 125 ASN C CB  1 
ATOM   3090 C CG  . ASN B 2 125 ? 156.620 161.977 199.275 1.00 73.97  ? 125 ASN C CG  1 
ATOM   3091 O OD1 . ASN B 2 125 ? 157.829 162.086 199.477 1.00 73.97  ? 125 ASN C OD1 1 
ATOM   3092 N ND2 . ASN B 2 125 ? 155.810 161.328 200.104 1.00 73.97  ? 125 ASN C ND2 1 
ATOM   3093 N N   . LEU B 2 126 ? 158.822 162.064 195.981 1.00 71.40  ? 126 LEU C N   1 
ATOM   3094 C CA  . LEU B 2 126 ? 159.398 161.171 194.982 1.00 71.40  ? 126 LEU C CA  1 
ATOM   3095 C C   . LEU B 2 126 ? 159.267 159.702 195.368 1.00 71.40  ? 126 LEU C C   1 
ATOM   3096 O O   . LEU B 2 126 ? 159.161 158.844 194.486 1.00 71.40  ? 126 LEU C O   1 
ATOM   3097 C CB  . LEU B 2 126 ? 160.867 161.521 194.749 1.00 71.40  ? 126 LEU C CB  1 
ATOM   3098 C CG  . LEU B 2 126 ? 161.161 162.986 194.424 1.00 71.40  ? 126 LEU C CG  1 
ATOM   3099 C CD1 . LEU B 2 126 ? 162.638 163.176 194.145 1.00 71.40  ? 126 LEU C CD1 1 
ATOM   3100 C CD2 . LEU B 2 126 ? 160.327 163.449 193.243 1.00 71.40  ? 126 LEU C CD2 1 
ATOM   3101 N N   . LYS B 2 127 ? 159.277 159.393 196.661 1.00 78.33  ? 127 LYS C N   1 
ATOM   3102 C CA  . LYS B 2 127 ? 159.230 158.018 197.146 1.00 78.33  ? 127 LYS C CA  1 
ATOM   3103 C C   . LYS B 2 127 ? 157.872 157.781 197.797 1.00 78.33  ? 127 LYS C C   1 
ATOM   3104 O O   . LYS B 2 127 ? 157.588 158.318 198.872 1.00 78.33  ? 127 LYS C O   1 
ATOM   3105 C CB  . LYS B 2 127 ? 160.372 157.759 198.124 1.00 78.33  ? 127 LYS C CB  1 
ATOM   3106 C CG  . LYS B 2 127 ? 161.747 157.983 197.516 1.00 78.33  ? 127 LYS C CG  1 
ATOM   3107 C CD  . LYS B 2 127 ? 162.851 157.799 198.541 1.00 78.33  ? 127 LYS C CD  1 
ATOM   3108 C CE  . LYS B 2 127 ? 164.214 158.097 197.938 1.00 78.33  ? 127 LYS C CE  1 
ATOM   3109 N NZ  . LYS B 2 127 ? 165.307 157.947 198.937 1.00 78.33  ? 127 LYS C NZ  1 
ATOM   3110 N N   . THR B 2 128 ? 157.041 156.970 197.145 1.00 95.24  ? 128 THR C N   1 
ATOM   3111 C CA  . THR B 2 128 ? 155.677 156.722 197.588 1.00 95.24  ? 128 THR C CA  1 
ATOM   3112 C C   . THR B 2 128 ? 155.386 155.239 197.398 1.00 95.24  ? 128 THR C C   1 
ATOM   3113 O O   . THR B 2 128 ? 155.906 154.622 196.464 1.00 95.24  ? 128 THR C O   1 
ATOM   3114 C CB  . THR B 2 128 ? 154.684 157.593 196.799 1.00 95.24  ? 128 THR C CB  1 
ATOM   3115 O OG1 . THR B 2 128 ? 155.083 158.966 196.885 1.00 95.24  ? 128 THR C OG1 1 
ATOM   3116 C CG2 . THR B 2 128 ? 153.266 157.474 197.349 1.00 95.24  ? 128 THR C CG2 1 
ATOM   3117 N N   . ARG B 2 129 ? 154.584 154.668 198.305 1.00 107.39 ? 129 ARG C N   1 
ATOM   3118 C CA  . ARG B 2 129 ? 154.178 153.270 198.172 1.00 107.39 ? 129 ARG C CA  1 
ATOM   3119 C C   . ARG B 2 129 ? 153.396 153.044 196.885 1.00 107.39 ? 129 ARG C C   1 
ATOM   3120 O O   . ARG B 2 129 ? 153.613 152.049 196.183 1.00 107.39 ? 129 ARG C O   1 
ATOM   3121 C CB  . ARG B 2 129 ? 153.351 152.846 199.386 1.00 107.39 ? 129 ARG C CB  1 
ATOM   3122 N N   . GLU B 2 130 ? 152.478 153.952 196.562 1.00 110.41 ? 130 GLU C N   1 
ATOM   3123 C CA  . GLU B 2 130 ? 151.893 153.979 195.229 1.00 110.41 ? 130 GLU C CA  1 
ATOM   3124 C C   . GLU B 2 130 ? 152.957 154.400 194.223 1.00 110.41 ? 130 GLU C C   1 
ATOM   3125 O O   . GLU B 2 130 ? 153.745 155.314 194.486 1.00 110.41 ? 130 GLU C O   1 
ATOM   3126 C CB  . GLU B 2 130 ? 150.706 154.942 195.197 1.00 110.41 ? 130 GLU C CB  1 
ATOM   3127 C CG  . GLU B 2 130 ? 150.051 155.103 193.835 1.00 110.41 ? 130 GLU C CG  1 
ATOM   3128 C CD  . GLU B 2 130 ? 149.037 154.016 193.542 1.00 110.41 ? 130 GLU C CD  1 
ATOM   3129 O OE1 . GLU B 2 130 ? 148.430 153.494 194.501 1.00 110.41 ? 130 GLU C OE1 1 
ATOM   3130 O OE2 . GLU B 2 130 ? 148.844 153.686 192.354 1.00 110.41 ? 130 GLU C OE2 1 
ATOM   3131 N N   . GLY B 2 131 ? 152.989 153.735 193.071 1.00 108.96 ? 131 GLY C N   1 
ATOM   3132 C CA  . GLY B 2 131 ? 154.041 154.023 192.118 1.00 108.96 ? 131 GLY C CA  1 
ATOM   3133 C C   . GLY B 2 131 ? 153.709 155.173 191.191 1.00 108.96 ? 131 GLY C C   1 
ATOM   3134 O O   . GLY B 2 131 ? 153.096 154.980 190.136 1.00 108.96 ? 131 GLY C O   1 
ATOM   3135 N N   . ASN B 2 132 ? 154.162 156.369 191.577 1.00 101.88 ? 132 ASN C N   1 
ATOM   3136 C CA  . ASN B 2 132 ? 153.961 157.620 190.851 1.00 101.88 ? 132 ASN C CA  1 
ATOM   3137 C C   . ASN B 2 132 ? 154.738 158.731 191.545 1.00 101.88 ? 132 ASN C C   1 
ATOM   3138 O O   . ASN B 2 132 ? 155.406 158.489 192.555 1.00 101.88 ? 132 ASN C O   1 
ATOM   3139 C CB  . ASN B 2 132 ? 152.477 157.998 190.766 1.00 101.88 ? 132 ASN C CB  1 
ATOM   3140 C CG  . ASN B 2 132 ? 151.748 157.821 192.086 1.00 101.88 ? 132 ASN C CG  1 
ATOM   3141 O OD1 . ASN B 2 132 ? 152.358 157.549 193.120 1.00 101.88 ? 132 ASN C OD1 1 
ATOM   3142 N ND2 . ASN B 2 132 ? 150.430 157.983 192.054 1.00 101.88 ? 132 ASN C ND2 1 
ATOM   3143 N N   . VAL B 2 133 ? 154.661 159.948 191.014 1.00 87.44  ? 133 VAL C N   1 
ATOM   3144 C CA  . VAL B 2 133 ? 155.164 161.137 191.692 1.00 87.44  ? 133 VAL C CA  1 
ATOM   3145 C C   . VAL B 2 133 ? 153.967 162.024 192.001 1.00 87.44  ? 133 VAL C C   1 
ATOM   3146 O O   . VAL B 2 133 ? 153.275 162.488 191.086 1.00 87.44  ? 133 VAL C O   1 
ATOM   3147 C CB  . VAL B 2 133 ? 156.206 161.884 190.847 1.00 87.44  ? 133 VAL C CB  1 
ATOM   3148 C CG1 . VAL B 2 133 ? 156.607 163.173 191.542 1.00 87.44  ? 133 VAL C CG1 1 
ATOM   3149 C CG2 . VAL B 2 133 ? 157.418 161.000 190.596 1.00 87.44  ? 133 VAL C CG2 1 
ATOM   3150 N N   . ARG B 2 134 ? 153.721 162.260 193.286 1.00 81.74  ? 134 ARG C N   1 
ATOM   3151 C CA  . ARG B 2 134 ? 152.527 162.953 193.744 1.00 81.74  ? 134 ARG C CA  1 
ATOM   3152 C C   . ARG B 2 134 ? 152.917 164.181 194.555 1.00 81.74  ? 134 ARG C C   1 
ATOM   3153 O O   . ARG B 2 134 ? 153.867 164.141 195.344 1.00 81.74  ? 134 ARG C O   1 
ATOM   3154 C CB  . ARG B 2 134 ? 151.644 162.017 194.584 1.00 81.74  ? 134 ARG C CB  1 
ATOM   3155 C CG  . ARG B 2 134 ? 150.328 162.622 195.051 1.00 81.74  ? 134 ARG C CG  1 
ATOM   3156 C CD  . ARG B 2 134 ? 149.401 162.901 193.878 1.00 81.74  ? 134 ARG C CD  1 
ATOM   3157 N NE  . ARG B 2 134 ? 148.117 163.437 194.314 1.00 81.74  ? 134 ARG C NE  1 
ATOM   3158 C CZ  . ARG B 2 134 ? 147.184 163.908 193.497 1.00 81.74  ? 134 ARG C CZ  1 
ATOM   3159 N NH1 . ARG B 2 134 ? 147.360 163.928 192.186 1.00 81.74  ? 134 ARG C NH1 1 
ATOM   3160 N NH2 . ARG B 2 134 ? 146.046 164.368 194.008 1.00 81.74  ? 134 ARG C NH2 1 
ATOM   3161 N N   . VAL B 2 135 ? 152.184 165.275 194.342 1.00 76.25  ? 135 VAL C N   1 
ATOM   3162 C CA  . VAL B 2 135 ? 152.394 166.496 195.110 1.00 76.25  ? 135 VAL C CA  1 
ATOM   3163 C C   . VAL B 2 135 ? 151.971 166.258 196.556 1.00 76.25  ? 135 VAL C C   1 
ATOM   3164 O O   . VAL B 2 135 ? 151.008 165.528 196.830 1.00 76.25  ? 135 VAL C O   1 
ATOM   3165 C CB  . VAL B 2 135 ? 151.636 167.666 194.458 1.00 76.25  ? 135 VAL C CB  1 
ATOM   3166 C CG1 . VAL B 2 135 ? 150.129 167.413 194.430 1.00 76.25  ? 135 VAL C CG1 1 
ATOM   3167 C CG2 . VAL B 2 135 ? 151.954 168.992 195.142 1.00 76.25  ? 135 VAL C CG2 1 
ATOM   3168 N N   . SER B 2 136 ? 152.727 166.825 197.496 1.00 73.30  ? 136 SER C N   1 
ATOM   3169 C CA  . SER B 2 136 ? 152.441 166.667 198.917 1.00 73.30  ? 136 SER C CA  1 
ATOM   3170 C C   . SER B 2 136 ? 151.859 167.937 199.528 1.00 73.30  ? 136 SER C C   1 
ATOM   3171 O O   . SER B 2 136 ? 150.766 167.911 200.101 1.00 73.30  ? 136 SER C O   1 
ATOM   3172 C CB  . SER B 2 136 ? 153.715 166.248 199.662 1.00 73.30  ? 136 SER C CB  1 
ATOM   3173 O OG  . SER B 2 136 ? 154.782 167.137 199.384 1.00 73.30  ? 136 SER C OG  1 
ATOM   3174 N N   . ARG B 2 137 ? 152.571 169.056 199.409 1.00 71.07  ? 137 ARG C N   1 
ATOM   3175 C CA  . ARG B 2 137 ? 152.137 170.324 199.975 1.00 71.07  ? 137 ARG C CA  1 
ATOM   3176 C C   . ARG B 2 137 ? 152.152 171.396 198.896 1.00 71.07  ? 137 ARG C C   1 
ATOM   3177 O O   . ARG B 2 137 ? 153.145 171.557 198.181 1.00 71.07  ? 137 ARG C O   1 
ATOM   3178 C CB  . ARG B 2 137 ? 153.031 170.747 201.148 1.00 71.07  ? 137 ARG C CB  1 
ATOM   3179 C CG  . ARG B 2 137 ? 152.656 172.082 201.772 1.00 71.07  ? 137 ARG C CG  1 
ATOM   3180 C CD  . ARG B 2 137 ? 151.229 172.076 202.304 1.00 71.07  ? 137 ARG C CD  1 
ATOM   3181 N NE  . ARG B 2 137 ? 151.069 171.196 203.455 1.00 71.07  ? 137 ARG C NE  1 
ATOM   3182 C CZ  . ARG B 2 137 ? 149.901 170.871 203.993 1.00 71.07  ? 137 ARG C CZ  1 
ATOM   3183 N NH1 . ARG B 2 137 ? 148.762 171.333 203.502 1.00 71.07  ? 137 ARG C NH1 1 
ATOM   3184 N NH2 . ARG B 2 137 ? 149.875 170.064 205.049 1.00 71.07  ? 137 ARG C NH2 1 
ATOM   3185 N N   . GLU B 2 138 ? 151.047 172.128 198.790 1.00 69.72  ? 138 GLU C N   1 
ATOM   3186 C CA  . GLU B 2 138 ? 150.879 173.200 197.813 1.00 69.72  ? 138 GLU C CA  1 
ATOM   3187 C C   . GLU B 2 138 ? 151.120 174.513 198.554 1.00 69.72  ? 138 GLU C C   1 
ATOM   3188 O O   . GLU B 2 138 ? 150.210 175.075 199.165 1.00 69.72  ? 138 GLU C O   1 
ATOM   3189 C CB  . GLU B 2 138 ? 149.490 173.151 197.184 1.00 69.72  ? 138 GLU C CB  1 
ATOM   3190 C CG  . GLU B 2 138 ? 149.366 173.893 195.867 1.00 69.72  ? 138 GLU C CG  1 
ATOM   3191 C CD  . GLU B 2 138 ? 150.026 173.153 194.722 1.00 69.72  ? 138 GLU C CD  1 
ATOM   3192 O OE1 . GLU B 2 138 ? 150.157 171.915 194.811 1.00 69.72  ? 138 GLU C OE1 1 
ATOM   3193 O OE2 . GLU B 2 138 ? 150.404 173.805 193.727 1.00 69.72  ? 138 GLU C OE2 1 
ATOM   3194 N N   . LEU B 2 139 ? 152.360 174.995 198.500 1.00 62.80  ? 139 LEU C N   1 
ATOM   3195 C CA  . LEU B 2 139 ? 152.772 176.150 199.290 1.00 62.80  ? 139 LEU C CA  1 
ATOM   3196 C C   . LEU B 2 139 ? 152.389 177.433 198.565 1.00 62.80  ? 139 LEU C C   1 
ATOM   3197 O O   . LEU B 2 139 ? 152.943 177.746 197.507 1.00 62.80  ? 139 LEU C O   1 
ATOM   3198 C CB  . LEU B 2 139 ? 154.273 176.109 199.554 1.00 62.80  ? 139 LEU C CB  1 
ATOM   3199 C CG  . LEU B 2 139 ? 154.811 174.999 200.454 1.00 62.80  ? 139 LEU C CG  1 
ATOM   3200 C CD1 . LEU B 2 139 ? 156.301 174.845 200.234 1.00 62.80  ? 139 LEU C CD1 1 
ATOM   3201 C CD2 . LEU B 2 139 ? 154.517 175.295 201.910 1.00 62.80  ? 139 LEU C CD2 1 
ATOM   3202 N N   . ALA B 2 140 ? 151.450 178.179 199.139 1.00 57.41  ? 140 ALA C N   1 
ATOM   3203 C CA  . ALA B 2 140 ? 151.039 179.474 198.622 1.00 57.41  ? 140 ALA C CA  1 
ATOM   3204 C C   . ALA B 2 140 ? 151.050 180.494 199.749 1.00 57.41  ? 140 ALA C C   1 
ATOM   3205 O O   . ALA B 2 140 ? 151.040 180.138 200.930 1.00 57.41  ? 140 ALA C O   1 
ATOM   3206 C CB  . ALA B 2 140 ? 149.646 179.412 197.988 1.00 57.41  ? 140 ALA C CB  1 
ATOM   3207 N N   . GLY B 2 141 ? 151.060 181.768 199.374 1.00 53.88  ? 141 GLY C N   1 
ATOM   3208 C CA  . GLY B 2 141 ? 151.151 182.837 200.346 1.00 53.88  ? 141 GLY C CA  1 
ATOM   3209 C C   . GLY B 2 141 ? 152.038 183.961 199.858 1.00 53.88  ? 141 GLY C C   1 
ATOM   3210 O O   . GLY B 2 141 ? 152.227 184.968 200.546 1.00 53.88  ? 141 GLY C O   1 
ATOM   3211 N N   . HIS B 2 142 ? 152.590 183.790 198.664 1.00 52.04  ? 142 HIS C N   1 
ATOM   3212 C CA  . HIS B 2 142 ? 153.458 184.780 198.050 1.00 52.04  ? 142 HIS C CA  1 
ATOM   3213 C C   . HIS B 2 142 ? 152.677 185.509 196.968 1.00 52.04  ? 142 HIS C C   1 
ATOM   3214 O O   . HIS B 2 142 ? 152.123 184.873 196.067 1.00 52.04  ? 142 HIS C O   1 
ATOM   3215 C CB  . HIS B 2 142 ? 154.690 184.112 197.447 1.00 52.04  ? 142 HIS C CB  1 
ATOM   3216 C CG  . HIS B 2 142 ? 155.814 183.937 198.415 1.00 52.04  ? 142 HIS C CG  1 
ATOM   3217 N ND1 . HIS B 2 142 ? 156.222 184.935 199.273 1.00 52.04  ? 142 HIS C ND1 1 
ATOM   3218 C CD2 . HIS B 2 142 ? 156.624 182.879 198.653 1.00 52.04  ? 142 HIS C CD2 1 
ATOM   3219 C CE1 . HIS B 2 142 ? 157.229 184.496 200.006 1.00 52.04  ? 142 HIS C CE1 1 
ATOM   3220 N NE2 . HIS B 2 142 ? 157.495 183.252 199.648 1.00 52.04  ? 142 HIS C NE2 1 
ATOM   3221 N N   . THR B 2 143 ? 152.628 186.837 197.058 1.00 54.43  ? 143 THR C N   1 
ATOM   3222 C CA  . THR B 2 143 ? 151.905 187.615 196.060 1.00 54.43  ? 143 THR C CA  1 
ATOM   3223 C C   . THR B 2 143 ? 152.708 187.830 194.784 1.00 54.43  ? 143 THR C C   1 
ATOM   3224 O O   . THR B 2 143 ? 152.136 188.261 193.778 1.00 54.43  ? 143 THR C O   1 
ATOM   3225 C CB  . THR B 2 143 ? 151.488 188.971 196.637 1.00 54.43  ? 143 THR C CB  1 
ATOM   3226 O OG1 . THR B 2 143 ? 152.646 189.791 196.826 1.00 54.43  ? 143 THR C OG1 1 
ATOM   3227 C CG2 . THR B 2 143 ? 150.782 188.788 197.972 1.00 54.43  ? 143 THR C CG2 1 
ATOM   3228 N N   . GLY B 2 144 ? 154.010 187.539 194.798 1.00 51.59  ? 144 GLY C N   1 
ATOM   3229 C CA  . GLY B 2 144 ? 154.847 187.642 193.627 1.00 51.59  ? 144 GLY C CA  1 
ATOM   3230 C C   . GLY B 2 144 ? 155.307 186.275 193.142 1.00 51.59  ? 144 GLY C C   1 
ATOM   3231 O O   . GLY B 2 144 ? 154.970 185.233 193.699 1.00 51.59  ? 144 GLY C O   1 
ATOM   3232 N N   . TYR B 2 145 ? 156.096 186.301 192.073 1.00 50.54  ? 145 TYR C N   1 
ATOM   3233 C CA  . TYR B 2 145 ? 156.582 185.066 191.474 1.00 50.54  ? 145 TYR C CA  1 
ATOM   3234 C C   . TYR B 2 145 ? 157.770 184.511 192.252 1.00 50.54  ? 145 TYR C C   1 
ATOM   3235 O O   . TYR B 2 145 ? 158.678 185.245 192.645 1.00 50.54  ? 145 TYR C O   1 
ATOM   3236 C CB  . TYR B 2 145 ? 156.963 185.305 190.010 1.00 50.54  ? 145 TYR C CB  1 
ATOM   3237 C CG  . TYR B 2 145 ? 158.217 186.123 189.798 1.00 50.54  ? 145 TYR C CG  1 
ATOM   3238 C CD1 . TYR B 2 145 ? 158.205 187.498 189.952 1.00 50.54  ? 145 TYR C CD1 1 
ATOM   3239 C CD2 . TYR B 2 145 ? 159.410 185.518 189.428 1.00 50.54  ? 145 TYR C CD2 1 
ATOM   3240 C CE1 . TYR B 2 145 ? 159.343 188.245 189.759 1.00 50.54  ? 145 TYR C CE1 1 
ATOM   3241 C CE2 . TYR B 2 145 ? 160.555 186.260 189.231 1.00 50.54  ? 145 TYR C CE2 1 
ATOM   3242 C CZ  . TYR B 2 145 ? 160.515 187.623 189.399 1.00 50.54  ? 145 TYR C CZ  1 
ATOM   3243 O OH  . TYR B 2 145 ? 161.653 188.370 189.203 1.00 50.54  ? 145 TYR C OH  1 
ATOM   3244 N N   . LEU B 2 146 ? 157.757 183.203 192.484 1.00 52.06  ? 146 LEU C N   1 
ATOM   3245 C CA  . LEU B 2 146 ? 158.879 182.559 193.147 1.00 52.06  ? 146 LEU C CA  1 
ATOM   3246 C C   . LEU B 2 146 ? 160.029 182.382 192.164 1.00 52.06  ? 146 LEU C C   1 
ATOM   3247 O O   . LEU B 2 146 ? 159.822 182.137 190.974 1.00 52.06  ? 146 LEU C O   1 
ATOM   3248 C CB  . LEU B 2 146 ? 158.470 181.207 193.727 1.00 52.06  ? 146 LEU C CB  1 
ATOM   3249 C CG  . LEU B 2 146 ? 157.760 181.224 195.085 1.00 52.06  ? 146 LEU C CG  1 
ATOM   3250 C CD1 . LEU B 2 146 ? 156.284 181.587 194.972 1.00 52.06  ? 146 LEU C CD1 1 
ATOM   3251 C CD2 . LEU B 2 146 ? 157.929 179.900 195.783 1.00 52.06  ? 146 LEU C CD2 1 
ATOM   3252 N N   . SER B 2 147 ? 161.251 182.514 192.671 1.00 47.58  ? 147 SER C N   1 
ATOM   3253 C CA  . SER B 2 147 ? 162.430 182.514 191.814 1.00 47.58  ? 147 SER C CA  1 
ATOM   3254 C C   . SER B 2 147 ? 163.547 181.591 192.267 1.00 47.58  ? 147 SER C C   1 
ATOM   3255 O O   . SER B 2 147 ? 164.367 181.201 191.428 1.00 47.58  ? 147 SER C O   1 
ATOM   3256 C CB  . SER B 2 147 ? 162.995 183.932 191.689 1.00 47.58  ? 147 SER C CB  1 
ATOM   3257 O OG  . SER B 2 147 ? 163.142 184.506 192.972 1.00 47.58  ? 147 SER C OG  1 
ATOM   3258 N N   . CYS B 2 148 ? 163.624 181.239 193.548 1.00 47.28  ? 148 CYS C N   1 
ATOM   3259 C CA  . CYS B 2 148 ? 164.643 180.316 194.022 1.00 47.28  ? 148 CYS C CA  1 
ATOM   3260 C C   . CYS B 2 148 ? 164.113 179.626 195.270 1.00 47.28  ? 148 CYS C C   1 
ATOM   3261 O O   . CYS B 2 148 ? 163.628 180.288 196.190 1.00 47.28  ? 148 CYS C O   1 
ATOM   3262 C CB  . CYS B 2 148 ? 165.959 181.041 194.307 1.00 47.28  ? 148 CYS C CB  1 
ATOM   3263 S SG  . CYS B 2 148 ? 167.413 179.986 194.239 1.00 47.28  ? 148 CYS C SG  1 
ATOM   3264 N N   . CYS B 2 149 ? 164.208 178.301 195.292 1.00 46.51  ? 149 CYS C N   1 
ATOM   3265 C CA  . CYS B 2 149 ? 163.516 177.480 196.281 1.00 46.51  ? 149 CYS C CA  1 
ATOM   3266 C C   . CYS B 2 149 ? 164.462 176.448 196.882 1.00 46.51  ? 149 CYS C C   1 
ATOM   3267 O O   . CYS B 2 149 ? 164.184 175.249 196.891 1.00 46.51  ? 149 CYS C O   1 
ATOM   3268 C CB  . CYS B 2 149 ? 162.293 176.810 195.666 1.00 46.51  ? 149 CYS C CB  1 
ATOM   3269 S SG  . CYS B 2 149 ? 160.962 177.944 195.255 1.00 46.51  ? 149 CYS C SG  1 
ATOM   3270 N N   . ARG B 2 150 ? 165.617 176.904 197.360 1.00 46.48  ? 150 ARG C N   1 
ATOM   3271 C CA  . ARG B 2 150 ? 166.624 175.994 197.893 1.00 46.48  ? 150 ARG C CA  1 
ATOM   3272 C C   . ARG B 2 150 ? 166.183 175.394 199.229 1.00 46.48  ? 150 ARG C C   1 
ATOM   3273 O O   . ARG B 2 150 ? 165.682 176.098 200.111 1.00 46.48  ? 150 ARG C O   1 
ATOM   3274 C CB  . ARG B 2 150 ? 167.949 176.736 198.041 1.00 46.48  ? 150 ARG C CB  1 
ATOM   3275 C CG  . ARG B 2 150 ? 168.555 177.168 196.709 1.00 46.48  ? 150 ARG C CG  1 
ATOM   3276 C CD  . ARG B 2 150 ? 168.812 175.974 195.801 1.00 46.48  ? 150 ARG C CD  1 
ATOM   3277 N NE  . ARG B 2 150 ? 169.051 176.359 194.414 1.00 46.48  ? 150 ARG C NE  1 
ATOM   3278 C CZ  . ARG B 2 150 ? 168.182 176.187 193.427 1.00 46.48  ? 150 ARG C CZ  1 
ATOM   3279 N NH1 . ARG B 2 150 ? 167.010 175.610 193.631 1.00 46.48  ? 150 ARG C NH1 1 
ATOM   3280 N NH2 . ARG B 2 150 ? 168.498 176.597 192.203 1.00 46.48  ? 150 ARG C NH2 1 
ATOM   3281 N N   . PHE B 2 151 ? 166.378 174.079 199.371 1.00 50.09  ? 151 PHE C N   1 
ATOM   3282 C CA  . PHE B 2 151 ? 165.909 173.308 200.524 1.00 50.09  ? 151 PHE C CA  1 
ATOM   3283 C C   . PHE B 2 151 ? 166.848 173.374 201.719 1.00 50.09  ? 151 PHE C C   1 
ATOM   3284 O O   . PHE B 2 151 ? 168.049 173.127 201.587 1.00 50.09  ? 151 PHE C O   1 
ATOM   3285 C CB  . PHE B 2 151 ? 165.727 171.838 200.151 1.00 50.09  ? 151 PHE C CB  1 
ATOM   3286 C CG  . PHE B 2 151 ? 164.445 171.532 199.465 1.00 50.09  ? 151 PHE C CG  1 
ATOM   3287 C CD1 . PHE B 2 151 ? 163.320 171.225 200.207 1.00 50.09  ? 151 PHE C CD1 1 
ATOM   3288 C CD2 . PHE B 2 151 ? 164.356 171.549 198.094 1.00 50.09  ? 151 PHE C CD2 1 
ATOM   3289 C CE1 . PHE B 2 151 ? 162.126 170.934 199.587 1.00 50.09  ? 151 PHE C CE1 1 
ATOM   3290 C CE2 . PHE B 2 151 ? 163.169 171.257 197.467 1.00 50.09  ? 151 PHE C CE2 1 
ATOM   3291 C CZ  . PHE B 2 151 ? 162.049 170.953 198.212 1.00 50.09  ? 151 PHE C CZ  1 
ATOM   3292 N N   . LEU B 2 152 ? 166.279 173.644 202.896 1.00 56.65  ? 152 LEU C N   1 
ATOM   3293 C CA  . LEU B 2 152 ? 167.017 173.458 204.141 1.00 56.65  ? 152 LEU C CA  1 
ATOM   3294 C C   . LEU B 2 152 ? 167.222 171.976 204.426 1.00 56.65  ? 152 LEU C C   1 
ATOM   3295 O O   . LEU B 2 152 ? 168.354 171.482 204.449 1.00 56.65  ? 152 LEU C O   1 
ATOM   3296 C CB  . LEU B 2 152 ? 166.270 174.117 205.304 1.00 56.65  ? 152 LEU C CB  1 
ATOM   3297 C CG  . LEU B 2 152 ? 166.506 175.590 205.638 1.00 56.65  ? 152 LEU C CG  1 
ATOM   3298 C CD1 . LEU B 2 152 ? 165.974 175.922 207.026 1.00 56.65  ? 152 LEU C CD1 1 
ATOM   3299 C CD2 . LEU B 2 152 ? 167.965 175.990 205.498 1.00 56.65  ? 152 LEU C CD2 1 
ATOM   3300 N N   . ASP B 2 153 ? 166.131 171.251 204.644 1.00 60.64  ? 153 ASP C N   1 
ATOM   3301 C CA  . ASP B 2 153 ? 166.173 169.817 204.902 1.00 60.64  ? 153 ASP C CA  1 
ATOM   3302 C C   . ASP B 2 153 ? 164.865 169.211 204.398 1.00 60.64  ? 153 ASP C C   1 
ATOM   3303 O O   . ASP B 2 153 ? 164.165 169.813 203.578 1.00 60.64  ? 153 ASP C O   1 
ATOM   3304 C CB  . ASP B 2 153 ? 166.455 169.540 206.391 1.00 60.64  ? 153 ASP C CB  1 
ATOM   3305 C CG  . ASP B 2 153 ? 165.360 170.050 207.308 1.00 60.64  ? 153 ASP C CG  1 
ATOM   3306 O OD1 . ASP B 2 153 ? 164.585 170.930 206.888 1.00 60.64  ? 153 ASP C OD1 1 
ATOM   3307 O OD2 . ASP B 2 153 ? 165.279 169.573 208.460 1.00 60.64  ? 153 ASP C OD2 1 
ATOM   3308 N N   . ASP B 2 154 ? 164.548 168.005 204.875 1.00 66.91  ? 154 ASP C N   1 
ATOM   3309 C CA  . ASP B 2 154 ? 163.342 167.299 204.454 1.00 66.91  ? 154 ASP C CA  1 
ATOM   3310 C C   . ASP B 2 154 ? 162.054 168.021 204.840 1.00 66.91  ? 154 ASP C C   1 
ATOM   3311 O O   . ASP B 2 154 ? 161.026 167.814 204.186 1.00 66.91  ? 154 ASP C O   1 
ATOM   3312 C CB  . ASP B 2 154 ? 163.347 165.887 205.049 1.00 66.91  ? 154 ASP C CB  1 
ATOM   3313 C CG  . ASP B 2 154 ? 162.351 164.963 204.378 1.00 66.91  ? 154 ASP C CG  1 
ATOM   3314 O OD1 . ASP B 2 154 ? 161.177 164.948 204.805 1.00 66.91  ? 154 ASP C OD1 1 
ATOM   3315 O OD2 . ASP B 2 154 ? 162.740 164.257 203.424 1.00 66.91  ? 154 ASP C OD2 1 
ATOM   3316 N N   . ASN B 2 155 ? 162.076 168.860 205.877 1.00 63.37  ? 155 ASN C N   1 
ATOM   3317 C CA  . ASN B 2 155 ? 160.861 169.504 206.352 1.00 63.37  ? 155 ASN C CA  1 
ATOM   3318 C C   . ASN B 2 155 ? 160.847 171.018 206.217 1.00 63.37  ? 155 ASN C C   1 
ATOM   3319 O O   . ASN B 2 155 ? 159.771 171.612 206.339 1.00 63.37  ? 155 ASN C O   1 
ATOM   3320 C CB  . ASN B 2 155 ? 160.600 169.148 207.824 1.00 63.37  ? 155 ASN C CB  1 
ATOM   3321 C CG  . ASN B 2 155 ? 159.121 169.027 208.139 1.00 63.37  ? 155 ASN C CG  1 
ATOM   3322 O OD1 . ASN B 2 155 ? 158.327 168.619 207.293 1.00 63.37  ? 155 ASN C OD1 1 
ATOM   3323 N ND2 . ASN B 2 155 ? 158.745 169.382 209.362 1.00 63.37  ? 155 ASN C ND2 1 
ATOM   3324 N N   . GLN B 2 156 ? 161.985 171.661 205.980 1.00 59.54  ? 156 GLN C N   1 
ATOM   3325 C CA  . GLN B 2 156 ? 162.043 173.112 205.884 1.00 59.54  ? 156 GLN C CA  1 
ATOM   3326 C C   . GLN B 2 156 ? 162.501 173.520 204.491 1.00 59.54  ? 156 GLN C C   1 
ATOM   3327 O O   . GLN B 2 156 ? 163.497 173.002 203.979 1.00 59.54  ? 156 GLN C O   1 
ATOM   3328 C CB  . GLN B 2 156 ? 162.967 173.697 206.952 1.00 59.54  ? 156 GLN C CB  1 
ATOM   3329 C CG  . GLN B 2 156 ? 162.543 173.339 208.369 1.00 59.54  ? 156 GLN C CG  1 
ATOM   3330 C CD  . GLN B 2 156 ? 161.243 174.004 208.778 1.00 59.54  ? 156 GLN C CD  1 
ATOM   3331 O OE1 . GLN B 2 156 ? 161.026 175.185 208.512 1.00 59.54  ? 156 GLN C OE1 1 
ATOM   3332 N NE2 . GLN B 2 156 ? 160.362 173.241 209.417 1.00 59.54  ? 156 GLN C NE2 1 
ATOM   3333 N N   . ILE B 2 157 ? 161.761 174.441 203.886 1.00 50.91  ? 157 ILE C N   1 
ATOM   3334 C CA  . ILE B 2 157 ? 162.017 174.954 202.547 1.00 50.91  ? 157 ILE C CA  1 
ATOM   3335 C C   . ILE B 2 157 ? 162.117 176.472 202.578 1.00 50.91  ? 157 ILE C C   1 
ATOM   3336 O O   . ILE B 2 157 ? 161.292 177.151 203.201 1.00 50.91  ? 157 ILE C O   1 
ATOM   3337 C CB  . ILE B 2 157 ? 160.941 174.465 201.549 1.00 50.91  ? 157 ILE C CB  1 
ATOM   3338 C CG1 . ILE B 2 157 ? 161.212 175.000 200.141 1.00 50.91  ? 157 ILE C CG1 1 
ATOM   3339 C CG2 . ILE B 2 157 ? 159.538 174.733 202.046 1.00 50.91  ? 157 ILE C CG2 1 
ATOM   3340 C CD1 . ILE B 2 157 ? 162.475 174.536 199.534 1.00 50.91  ? 157 ILE C CD1 1 
ATOM   3341 N N   . VAL B 2 158 ? 163.150 177.000 201.927 1.00 45.02  ? 158 VAL C N   1 
ATOM   3342 C CA  . VAL B 2 158 ? 163.375 178.434 201.810 1.00 45.02  ? 158 VAL C CA  1 
ATOM   3343 C C   . VAL B 2 158 ? 163.041 178.849 200.388 1.00 45.02  ? 158 VAL C C   1 
ATOM   3344 O O   . VAL B 2 158 ? 163.606 178.309 199.431 1.00 45.02  ? 158 VAL C O   1 
ATOM   3345 C CB  . VAL B 2 158 ? 164.820 178.814 202.167 1.00 45.02  ? 158 VAL C CB  1 
ATOM   3346 C CG1 . VAL B 2 158 ? 164.969 180.318 202.231 1.00 45.02  ? 158 VAL C CG1 1 
ATOM   3347 C CG2 . VAL B 2 158 ? 165.188 178.217 203.490 1.00 45.02  ? 158 VAL C CG2 1 
ATOM   3348 N N   . THR B 2 159 ? 162.125 179.805 200.251 1.00 46.23  ? 159 THR C N   1 
ATOM   3349 C CA  . THR B 2 159 ? 161.632 180.257 198.957 1.00 46.23  ? 159 THR C CA  1 
ATOM   3350 C C   . THR B 2 159 ? 161.966 181.728 198.787 1.00 46.23  ? 159 THR C C   1 
ATOM   3351 O O   . THR B 2 159 ? 161.703 182.534 199.684 1.00 46.23  ? 159 THR C O   1 
ATOM   3352 C CB  . THR B 2 159 ? 160.123 180.050 198.841 1.00 46.23  ? 159 THR C CB  1 
ATOM   3353 O OG1 . THR B 2 159 ? 159.475 180.643 199.972 1.00 46.23  ? 159 THR C OG1 1 
ATOM   3354 C CG2 . THR B 2 159 ? 159.791 178.567 198.797 1.00 46.23  ? 159 THR C CG2 1 
ATOM   3355 N N   . SER B 2 160 ? 162.549 182.071 197.646 1.00 49.17  ? 160 SER C N   1 
ATOM   3356 C CA  . SER B 2 160 ? 162.755 183.458 197.255 1.00 49.17  ? 160 SER C CA  1 
ATOM   3357 C C   . SER B 2 160 ? 161.650 183.833 196.277 1.00 49.17  ? 160 SER C C   1 
ATOM   3358 O O   . SER B 2 160 ? 161.384 183.091 195.324 1.00 49.17  ? 160 SER C O   1 
ATOM   3359 C CB  . SER B 2 160 ? 164.133 183.657 196.632 1.00 49.17  ? 160 SER C CB  1 
ATOM   3360 O OG  . SER B 2 160 ? 164.161 184.829 195.844 1.00 49.17  ? 160 SER C OG  1 
ATOM   3361 N N   . SER B 2 161 ? 161.011 184.976 196.510 1.00 50.15  ? 161 SER C N   1 
ATOM   3362 C CA  . SER B 2 161 ? 159.734 185.296 195.891 1.00 50.15  ? 161 SER C CA  1 
ATOM   3363 C C   . SER B 2 161 ? 159.805 186.637 195.172 1.00 50.15  ? 161 SER C C   1 
ATOM   3364 O O   . SER B 2 161 ? 160.840 187.309 195.149 1.00 50.15  ? 161 SER C O   1 
ATOM   3365 C CB  . SER B 2 161 ? 158.623 185.306 196.941 1.00 50.15  ? 161 SER C CB  1 
ATOM   3366 O OG  . SER B 2 161 ? 157.496 186.029 196.486 1.00 50.15  ? 161 SER C OG  1 
ATOM   3367 N N   . GLY B 2 162 ? 158.681 187.014 194.565 1.00 52.25  ? 162 GLY C N   1 
ATOM   3368 C CA  . GLY B 2 162 ? 158.528 188.241 193.814 1.00 52.25  ? 162 GLY C CA  1 
ATOM   3369 C C   . GLY B 2 162 ? 157.987 189.423 194.579 1.00 52.25  ? 162 GLY C C   1 
ATOM   3370 O O   . GLY B 2 162 ? 158.056 190.551 194.083 1.00 52.25  ? 162 GLY C O   1 
ATOM   3371 N N   . ASP B 2 163 ? 157.463 189.213 195.786 1.00 54.85  ? 163 ASP C N   1 
ATOM   3372 C CA  . ASP B 2 163 ? 157.028 190.306 196.641 1.00 54.85  ? 163 ASP C CA  1 
ATOM   3373 C C   . ASP B 2 163 ? 158.161 190.843 197.508 1.00 54.85  ? 163 ASP C C   1 
ATOM   3374 O O   . ASP B 2 163 ? 157.902 191.356 198.604 1.00 54.85  ? 163 ASP C O   1 
ATOM   3375 C CB  . ASP B 2 163 ? 155.844 189.868 197.506 1.00 54.85  ? 163 ASP C CB  1 
ATOM   3376 C CG  . ASP B 2 163 ? 156.096 188.561 198.229 1.00 54.85  ? 163 ASP C CG  1 
ATOM   3377 O OD1 . ASP B 2 163 ? 157.168 187.962 198.023 1.00 54.85  ? 163 ASP C OD1 1 
ATOM   3378 O OD2 . ASP B 2 163 ? 155.213 188.126 198.998 1.00 54.85  ? 163 ASP C OD2 1 
ATOM   3379 N N   . THR B 2 164 ? 159.408 190.704 197.041 1.00 52.46  ? 164 THR C N   1 
ATOM   3380 C CA  . THR B 2 164 ? 160.630 191.213 197.665 1.00 52.46  ? 164 THR C CA  1 
ATOM   3381 C C   . THR B 2 164 ? 160.855 190.657 199.068 1.00 52.46  ? 164 THR C C   1 
ATOM   3382 O O   . THR B 2 164 ? 161.502 191.303 199.897 1.00 52.46  ? 164 THR C O   1 
ATOM   3383 C CB  . THR B 2 164 ? 160.658 192.748 197.692 1.00 52.46  ? 164 THR C CB  1 
ATOM   3384 O OG1 . THR B 2 164 ? 159.748 193.232 198.687 1.00 52.46  ? 164 THR C OG1 1 
ATOM   3385 C CG2 . THR B 2 164 ? 160.272 193.319 196.334 1.00 52.46  ? 164 THR C CG2 1 
ATOM   3386 N N   . THR B 2 165 ? 160.340 189.463 199.351 1.00 52.13  ? 165 THR C N   1 
ATOM   3387 C CA  . THR B 2 165 ? 160.482 188.846 200.661 1.00 52.13  ? 165 THR C CA  1 
ATOM   3388 C C   . THR B 2 165 ? 160.832 187.375 200.505 1.00 52.13  ? 165 THR C C   1 
ATOM   3389 O O   . THR B 2 165 ? 160.266 186.670 199.665 1.00 52.13  ? 165 THR C O   1 
ATOM   3390 C CB  . THR B 2 165 ? 159.200 188.968 201.500 1.00 52.13  ? 165 THR C CB  1 
ATOM   3391 O OG1 . THR B 2 165 ? 158.074 188.553 200.718 1.00 52.13  ? 165 THR C OG1 1 
ATOM   3392 C CG2 . THR B 2 165 ? 158.991 190.396 201.987 1.00 52.13  ? 165 THR C CG2 1 
ATOM   3393 N N   . CYS B 2 166 ? 161.763 186.917 201.336 1.00 51.53  ? 166 CYS C N   1 
ATOM   3394 C CA  . CYS B 2 166 ? 162.128 185.512 201.429 1.00 51.53  ? 166 CYS C CA  1 
ATOM   3395 C C   . CYS B 2 166 ? 161.338 184.864 202.556 1.00 51.53  ? 166 CYS C C   1 
ATOM   3396 O O   . CYS B 2 166 ? 160.931 185.531 203.510 1.00 51.53  ? 166 CYS C O   1 
ATOM   3397 C CB  . CYS B 2 166 ? 163.625 185.356 201.676 1.00 51.53  ? 166 CYS C CB  1 
ATOM   3398 S SG  . CYS B 2 166 ? 164.647 186.343 200.569 1.00 51.53  ? 166 CYS C SG  1 
ATOM   3399 N N   . ALA B 2 167 ? 161.113 183.559 202.442 1.00 50.12  ? 167 ALA C N   1 
ATOM   3400 C CA  . ALA B 2 167 ? 160.217 182.870 203.359 1.00 50.12  ? 167 ALA C CA  1 
ATOM   3401 C C   . ALA B 2 167 ? 160.704 181.459 203.642 1.00 50.12  ? 167 ALA C C   1 
ATOM   3402 O O   . ALA B 2 167 ? 161.221 180.778 202.755 1.00 50.12  ? 167 ALA C O   1 
ATOM   3403 C CB  . ALA B 2 167 ? 158.791 182.818 202.800 1.00 50.12  ? 167 ALA C CB  1 
ATOM   3404 N N   . LEU B 2 168 ? 160.521 181.030 204.886 1.00 53.79  ? 168 LEU C N   1 
ATOM   3405 C CA  . LEU B 2 168 ? 160.808 179.673 205.326 1.00 53.79  ? 168 LEU C CA  1 
ATOM   3406 C C   . LEU B 2 168 ? 159.492 179.008 205.705 1.00 53.79  ? 168 LEU C C   1 
ATOM   3407 O O   . LEU B 2 168 ? 158.738 179.546 206.523 1.00 53.79  ? 168 LEU C O   1 
ATOM   3408 C CB  . LEU B 2 168 ? 161.772 179.681 206.509 1.00 53.79  ? 168 LEU C CB  1 
ATOM   3409 C CG  . LEU B 2 168 ? 161.985 178.347 207.220 1.00 53.79  ? 168 LEU C CG  1 
ATOM   3410 C CD1 . LEU B 2 168 ? 162.578 177.327 206.267 1.00 53.79  ? 168 LEU C CD1 1 
ATOM   3411 C CD2 . LEU B 2 168 ? 162.874 178.530 208.437 1.00 53.79  ? 168 LEU C CD2 1 
ATOM   3412 N N   . TRP B 2 169 ? 159.221 177.845 205.126 1.00 56.81  ? 169 TRP C N   1 
ATOM   3413 C CA  . TRP B 2 169 ? 157.922 177.203 205.258 1.00 56.81  ? 169 TRP C CA  1 
ATOM   3414 C C   . TRP B 2 169 ? 158.030 175.904 206.044 1.00 56.81  ? 169 TRP C C   1 
ATOM   3415 O O   . TRP B 2 169 ? 159.117 175.441 206.394 1.00 56.81  ? 169 TRP C O   1 
ATOM   3416 C CB  . TRP B 2 169 ? 157.311 176.911 203.884 1.00 56.81  ? 169 TRP C CB  1 
ATOM   3417 C CG  . TRP B 2 169 ? 157.272 178.063 202.936 1.00 56.81  ? 169 TRP C CG  1 
ATOM   3418 C CD1 . TRP B 2 169 ? 158.320 178.604 202.251 1.00 56.81  ? 169 TRP C CD1 1 
ATOM   3419 C CD2 . TRP B 2 169 ? 156.114 178.805 202.546 1.00 56.81  ? 169 TRP C CD2 1 
ATOM   3420 N NE1 . TRP B 2 169 ? 157.887 179.644 201.468 1.00 56.81  ? 169 TRP C NE1 1 
ATOM   3421 C CE2 . TRP B 2 169 ? 156.535 179.787 201.631 1.00 56.81  ? 169 TRP C CE2 1 
ATOM   3422 C CE3 . TRP B 2 169 ? 154.761 178.739 202.890 1.00 56.81  ? 169 TRP C CE3 1 
ATOM   3423 C CZ2 . TRP B 2 169 ? 155.654 180.692 201.054 1.00 56.81  ? 169 TRP C CZ2 1 
ATOM   3424 C CZ3 . TRP B 2 169 ? 153.888 179.636 202.315 1.00 56.81  ? 169 TRP C CZ3 1 
ATOM   3425 C CH2 . TRP B 2 169 ? 154.337 180.602 201.407 1.00 56.81  ? 169 TRP C CH2 1 
ATOM   3426 N N   . ASP B 2 170 ? 156.866 175.314 206.308 1.00 64.84  ? 170 ASP C N   1 
ATOM   3427 C CA  . ASP B 2 170 ? 156.749 173.970 206.858 1.00 64.84  ? 170 ASP C CA  1 
ATOM   3428 C C   . ASP B 2 170 ? 155.965 173.114 205.878 1.00 64.84  ? 170 ASP C C   1 
ATOM   3429 O O   . ASP B 2 170 ? 154.968 173.569 205.310 1.00 64.84  ? 170 ASP C O   1 
ATOM   3430 C CB  . ASP B 2 170 ? 156.048 173.967 208.216 1.00 64.84  ? 170 ASP C CB  1 
ATOM   3431 C CG  . ASP B 2 170 ? 156.869 174.621 209.299 1.00 64.84  ? 170 ASP C CG  1 
ATOM   3432 O OD1 . ASP B 2 170 ? 158.114 174.607 209.194 1.00 64.84  ? 170 ASP C OD1 1 
ATOM   3433 O OD2 . ASP B 2 170 ? 156.267 175.136 210.264 1.00 64.84  ? 170 ASP C OD2 1 
ATOM   3434 N N   . ILE B 2 171 ? 156.420 171.878 205.679 1.00 66.85  ? 171 ILE C N   1 
ATOM   3435 C CA  . ILE B 2 171 ? 155.743 170.981 204.750 1.00 66.85  ? 171 ILE C CA  1 
ATOM   3436 C C   . ILE B 2 171 ? 154.404 170.522 205.320 1.00 66.85  ? 171 ILE C C   1 
ATOM   3437 O O   . ILE B 2 171 ? 153.394 170.473 204.608 1.00 66.85  ? 171 ILE C O   1 
ATOM   3438 C CB  . ILE B 2 171 ? 156.659 169.792 204.408 1.00 66.85  ? 171 ILE C CB  1 
ATOM   3439 C CG1 . ILE B 2 171 ? 157.985 170.300 203.837 1.00 66.85  ? 171 ILE C CG1 1 
ATOM   3440 C CG2 . ILE B 2 171 ? 155.983 168.853 203.421 1.00 66.85  ? 171 ILE C CG2 1 
ATOM   3441 C CD1 . ILE B 2 171 ? 157.837 171.126 202.579 1.00 66.85  ? 171 ILE C CD1 1 
ATOM   3442 N N   . GLU B 2 172 ? 154.369 170.194 206.614 1.00 69.38  ? 172 GLU C N   1 
ATOM   3443 C CA  . GLU B 2 172 ? 153.180 169.589 207.205 1.00 69.38  ? 172 GLU C CA  1 
ATOM   3444 C C   . GLU B 2 172 ? 152.047 170.585 207.436 1.00 69.38  ? 172 GLU C C   1 
ATOM   3445 O O   . GLU B 2 172 ? 150.893 170.165 207.566 1.00 69.38  ? 172 GLU C O   1 
ATOM   3446 C CB  . GLU B 2 172 ? 153.547 168.900 208.521 1.00 69.38  ? 172 GLU C CB  1 
ATOM   3447 C CG  . GLU B 2 172 ? 153.895 169.849 209.659 1.00 69.38  ? 172 GLU C CG  1 
ATOM   3448 C CD  . GLU B 2 172 ? 155.368 170.218 209.694 1.00 69.38  ? 172 GLU C CD  1 
ATOM   3449 O OE1 . GLU B 2 172 ? 156.073 169.987 208.688 1.00 69.38  ? 172 GLU C OE1 1 
ATOM   3450 O OE2 . GLU B 2 172 ? 155.823 170.743 210.732 1.00 69.38  ? 172 GLU C OE2 1 
ATOM   3451 N N   . THR B 2 173 ? 152.338 171.885 207.490 1.00 66.98  ? 173 THR C N   1 
ATOM   3452 C CA  . THR B 2 173 ? 151.304 172.889 207.711 1.00 66.98  ? 173 THR C CA  1 
ATOM   3453 C C   . THR B 2 173 ? 151.122 173.848 206.547 1.00 66.98  ? 173 THR C C   1 
ATOM   3454 O O   . THR B 2 173 ? 150.004 174.314 206.320 1.00 66.98  ? 173 THR C O   1 
ATOM   3455 C CB  . THR B 2 173 ? 151.604 173.707 208.975 1.00 66.98  ? 173 THR C CB  1 
ATOM   3456 O OG1 . THR B 2 173 ? 152.876 174.352 208.841 1.00 66.98  ? 173 THR C OG1 1 
ATOM   3457 C CG2 . THR B 2 173 ? 151.619 172.809 210.203 1.00 66.98  ? 173 THR C CG2 1 
ATOM   3458 N N   . GLY B 2 174 ? 152.184 174.153 205.807 1.00 64.93  ? 174 GLY C N   1 
ATOM   3459 C CA  . GLY B 2 174 ? 152.082 175.048 204.674 1.00 64.93  ? 174 GLY C CA  1 
ATOM   3460 C C   . GLY B 2 174 ? 152.201 176.520 204.992 1.00 64.93  ? 174 GLY C C   1 
ATOM   3461 O O   . GLY B 2 174 ? 152.086 177.342 204.077 1.00 64.93  ? 174 GLY C O   1 
ATOM   3462 N N   . GLN B 2 175 ? 152.432 176.882 206.248 1.00 63.34  ? 175 GLN C N   1 
ATOM   3463 C CA  . GLN B 2 175 ? 152.540 178.276 206.649 1.00 63.34  ? 175 GLN C CA  1 
ATOM   3464 C C   . GLN B 2 175 ? 154.002 178.688 206.756 1.00 63.34  ? 175 GLN C C   1 
ATOM   3465 O O   . GLN B 2 175 ? 154.892 177.866 206.984 1.00 63.34  ? 175 GLN C O   1 
ATOM   3466 C CB  . GLN B 2 175 ? 151.835 178.513 207.987 1.00 63.34  ? 175 GLN C CB  1 
ATOM   3467 C CG  . GLN B 2 175 ? 150.505 177.794 208.130 1.00 63.34  ? 175 GLN C CG  1 
ATOM   3468 C CD  . GLN B 2 175 ? 149.537 178.126 207.013 1.00 63.34  ? 175 GLN C CD  1 
ATOM   3469 O OE1 . GLN B 2 175 ? 149.077 179.261 206.893 1.00 63.34  ? 175 GLN C OE1 1 
ATOM   3470 N NE2 . GLN B 2 175 ? 149.220 177.134 206.190 1.00 63.34  ? 175 GLN C NE2 1 
ATOM   3471 N N   . GLN B 2 176 ? 154.240 179.985 206.589 1.00 56.17  ? 176 GLN C N   1 
ATOM   3472 C CA  . GLN B 2 176 ? 155.577 180.538 206.748 1.00 56.17  ? 176 GLN C CA  1 
ATOM   3473 C C   . GLN B 2 176 ? 155.902 180.652 208.230 1.00 56.17  ? 176 GLN C C   1 
ATOM   3474 O O   . GLN B 2 176 ? 155.160 181.290 208.984 1.00 56.17  ? 176 GLN C O   1 
ATOM   3475 C CB  . GLN B 2 176 ? 155.683 181.910 206.090 1.00 56.17  ? 176 GLN C CB  1 
ATOM   3476 C CG  . GLN B 2 176 ? 155.411 181.939 204.607 1.00 56.17  ? 176 GLN C CG  1 
ATOM   3477 C CD  . GLN B 2 176 ? 155.503 183.341 204.047 1.00 56.17  ? 176 GLN C CD  1 
ATOM   3478 O OE1 . GLN B 2 176 ? 155.722 184.300 204.784 1.00 56.17  ? 176 GLN C OE1 1 
ATOM   3479 N NE2 . GLN B 2 176 ? 155.341 183.468 202.738 1.00 56.17  ? 176 GLN C NE2 1 
ATOM   3480 N N   . THR B 2 177 ? 157.002 180.031 208.651 1.00 57.05  ? 177 THR C N   1 
ATOM   3481 C CA  . THR B 2 177 ? 157.479 180.249 210.011 1.00 57.05  ? 177 THR C CA  1 
ATOM   3482 C C   . THR B 2 177 ? 157.993 181.671 210.176 1.00 57.05  ? 177 THR C C   1 
ATOM   3483 O O   . THR B 2 177 ? 157.636 182.367 211.133 1.00 57.05  ? 177 THR C O   1 
ATOM   3484 C CB  . THR B 2 177 ? 158.574 179.243 210.360 1.00 57.05  ? 177 THR C CB  1 
ATOM   3485 O OG1 . THR B 2 177 ? 159.758 179.547 209.613 1.00 57.05  ? 177 THR C OG1 1 
ATOM   3486 C CG2 . THR B 2 177 ? 158.123 177.842 210.027 1.00 57.05  ? 177 THR C CG2 1 
ATOM   3487 N N   . THR B 2 178 ? 158.823 182.123 209.240 1.00 54.97  ? 178 THR C N   1 
ATOM   3488 C CA  . THR B 2 178 ? 159.377 183.466 209.263 1.00 54.97  ? 178 THR C CA  1 
ATOM   3489 C C   . THR B 2 178 ? 159.233 184.083 207.883 1.00 54.97  ? 178 THR C C   1 
ATOM   3490 O O   . THR B 2 178 ? 159.164 183.379 206.874 1.00 54.97  ? 178 THR C O   1 
ATOM   3491 C CB  . THR B 2 178 ? 160.855 183.476 209.681 1.00 54.97  ? 178 THR C CB  1 
ATOM   3492 O OG1 . THR B 2 178 ? 161.561 182.448 208.975 1.00 54.97  ? 178 THR C OG1 1 
ATOM   3493 C CG2 . THR B 2 178 ? 160.996 183.242 211.178 1.00 54.97  ? 178 THR C CG2 1 
ATOM   3494 N N   . THR B 2 179 ? 159.176 185.409 207.852 1.00 52.05  ? 179 THR C N   1 
ATOM   3495 C CA  . THR B 2 179 ? 159.156 186.167 206.611 1.00 52.05  ? 179 THR C CA  1 
ATOM   3496 C C   . THR B 2 179 ? 160.308 187.159 206.638 1.00 52.05  ? 179 THR C C   1 
ATOM   3497 O O   . THR B 2 179 ? 160.338 188.059 207.483 1.00 52.05  ? 179 THR C O   1 
ATOM   3498 C CB  . THR B 2 179 ? 157.824 186.896 206.428 1.00 52.05  ? 179 THR C CB  1 
ATOM   3499 O OG1 . THR B 2 179 ? 156.745 185.987 206.681 1.00 52.05  ? 179 THR C OG1 1 
ATOM   3500 C CG2 . THR B 2 179 ? 157.705 187.430 205.011 1.00 52.05  ? 179 THR C CG2 1 
ATOM   3501 N N   . PHE B 2 180 ? 161.245 186.998 205.714 1.00 51.27  ? 180 PHE C N   1 
ATOM   3502 C CA  . PHE B 2 180 ? 162.469 187.792 205.691 1.00 51.27  ? 180 PHE C CA  1 
ATOM   3503 C C   . PHE B 2 180 ? 162.174 189.044 204.879 1.00 51.27  ? 180 PHE C C   1 
ATOM   3504 O O   . PHE B 2 180 ? 161.902 188.969 203.679 1.00 51.27  ? 180 PHE C O   1 
ATOM   3505 C CB  . PHE B 2 180 ? 163.627 186.991 205.106 1.00 51.27  ? 180 PHE C CB  1 
ATOM   3506 C CG  . PHE B 2 180 ? 163.878 185.688 205.812 1.00 51.27  ? 180 PHE C CG  1 
ATOM   3507 C CD1 . PHE B 2 180 ? 164.634 185.648 206.970 1.00 51.27  ? 180 PHE C CD1 1 
ATOM   3508 C CD2 . PHE B 2 180 ? 163.364 184.503 205.312 1.00 51.27  ? 180 PHE C CD2 1 
ATOM   3509 C CE1 . PHE B 2 180 ? 164.863 184.455 207.620 1.00 51.27  ? 180 PHE C CE1 1 
ATOM   3510 C CE2 . PHE B 2 180 ? 163.592 183.306 205.957 1.00 51.27  ? 180 PHE C CE2 1 
ATOM   3511 C CZ  . PHE B 2 180 ? 164.339 183.282 207.114 1.00 51.27  ? 180 PHE C CZ  1 
ATOM   3512 N N   . THR B 2 181 ? 162.218 190.194 205.539 1.00 53.92  ? 181 THR C N   1 
ATOM   3513 C CA  . THR B 2 181 ? 161.784 191.452 204.954 1.00 53.92  ? 181 THR C CA  1 
ATOM   3514 C C   . THR B 2 181 ? 162.891 192.495 205.072 1.00 53.92  ? 181 THR C C   1 
ATOM   3515 O O   . THR B 2 181 ? 163.553 192.606 206.107 1.00 53.92  ? 181 THR C O   1 
ATOM   3516 C CB  . THR B 2 181 ? 160.501 191.941 205.644 1.00 53.92  ? 181 THR C CB  1 
ATOM   3517 O OG1 . THR B 2 181 ? 159.492 190.929 205.534 1.00 53.92  ? 181 THR C OG1 1 
ATOM   3518 C CG2 . THR B 2 181 ? 159.972 193.221 205.006 1.00 53.92  ? 181 THR C CG2 1 
ATOM   3519 N N   . GLY B 2 182 ? 163.071 193.276 204.010 1.00 49.95  ? 182 GLY C N   1 
ATOM   3520 C CA  . GLY B 2 182 ? 164.094 194.298 203.998 1.00 49.95  ? 182 GLY C CA  1 
ATOM   3521 C C   . GLY B 2 182 ? 164.671 194.560 202.625 1.00 49.95  ? 182 GLY C C   1 
ATOM   3522 O O   . GLY B 2 182 ? 165.362 195.562 202.420 1.00 49.95  ? 182 GLY C O   1 
ATOM   3523 N N   . HIS B 2 183 ? 164.387 193.680 201.671 1.00 54.71  ? 183 HIS C N   1 
ATOM   3524 C CA  . HIS B 2 183 ? 164.801 193.903 200.292 1.00 54.71  ? 183 HIS C CA  1 
ATOM   3525 C C   . HIS B 2 183 ? 163.843 194.875 199.621 1.00 54.71  ? 183 HIS C C   1 
ATOM   3526 O O   . HIS B 2 183 ? 162.640 194.611 199.532 1.00 54.71  ? 183 HIS C O   1 
ATOM   3527 C CB  . HIS B 2 183 ? 164.861 192.582 199.529 1.00 54.71  ? 183 HIS C CB  1 
ATOM   3528 C CG  . HIS B 2 183 ? 166.203 191.923 199.581 1.00 54.71  ? 183 HIS C CG  1 
ATOM   3529 N ND1 . HIS B 2 183 ? 166.397 190.596 199.269 1.00 54.71  ? 183 HIS C ND1 1 
ATOM   3530 C CD2 . HIS B 2 183 ? 167.424 192.421 199.882 1.00 54.71  ? 183 HIS C CD2 1 
ATOM   3531 C CE1 . HIS B 2 183 ? 167.678 190.300 199.391 1.00 54.71  ? 183 HIS C CE1 1 
ATOM   3532 N NE2 . HIS B 2 183 ? 168.324 191.391 199.761 1.00 54.71  ? 183 HIS C NE2 1 
ATOM   3533 N N   . THR B 2 184 ? 164.373 196.010 199.164 1.00 58.13  ? 184 THR C N   1 
ATOM   3534 C CA  . THR B 2 184 ? 163.540 196.978 198.463 1.00 58.13  ? 184 THR C CA  1 
ATOM   3535 C C   . THR B 2 184 ? 163.210 196.510 197.051 1.00 58.13  ? 184 THR C C   1 
ATOM   3536 O O   . THR B 2 184 ? 162.059 196.609 196.615 1.00 58.13  ? 184 THR C O   1 
ATOM   3537 C CB  . THR B 2 184 ? 164.233 198.339 198.422 1.00 58.13  ? 184 THR C CB  1 
ATOM   3538 O OG1 . THR B 2 184 ? 165.438 198.240 197.655 1.00 58.13  ? 184 THR C OG1 1 
ATOM   3539 C CG2 . THR B 2 184 ? 164.580 198.795 199.828 1.00 58.13  ? 184 THR C CG2 1 
ATOM   3540 N N   . GLY B 2 185 ? 164.202 195.990 196.329 1.00 57.74  ? 185 GLY C N   1 
ATOM   3541 C CA  . GLY B 2 185 ? 163.977 195.523 194.978 1.00 57.74  ? 185 GLY C CA  1 
ATOM   3542 C C   . GLY B 2 185 ? 163.514 194.079 194.925 1.00 57.74  ? 185 GLY C C   1 
ATOM   3543 O O   . GLY B 2 185 ? 163.495 193.370 195.928 1.00 57.74  ? 185 GLY C O   1 
ATOM   3544 N N   . ASP B 2 186 ? 163.148 193.653 193.719 1.00 53.80  ? 186 ASP C N   1 
ATOM   3545 C CA  . ASP B 2 186 ? 162.675 192.292 193.509 1.00 53.80  ? 186 ASP C CA  1 
ATOM   3546 C C   . ASP B 2 186 ? 163.823 191.300 193.649 1.00 53.80  ? 186 ASP C C   1 
ATOM   3547 O O   . ASP B 2 186 ? 164.974 191.611 193.338 1.00 53.80  ? 186 ASP C O   1 
ATOM   3548 C CB  . ASP B 2 186 ? 162.024 192.168 192.136 1.00 53.80  ? 186 ASP C CB  1 
ATOM   3549 C CG  . ASP B 2 186 ? 161.043 191.025 192.062 1.00 53.80  ? 186 ASP C CG  1 
ATOM   3550 O OD1 . ASP B 2 186 ? 160.953 190.249 193.035 1.00 53.80  ? 186 ASP C OD1 1 
ATOM   3551 O OD2 . ASP B 2 186 ? 160.347 190.915 191.033 1.00 53.80  ? 186 ASP C OD2 1 
ATOM   3552 N N   . VAL B 2 187 ? 163.502 190.098 194.124 1.00 51.54  ? 187 VAL C N   1 
ATOM   3553 C CA  . VAL B 2 187 ? 164.495 189.134 194.588 1.00 51.54  ? 187 VAL C CA  1 
ATOM   3554 C C   . VAL B 2 187 ? 164.463 187.910 193.684 1.00 51.54  ? 187 VAL C C   1 
ATOM   3555 O O   . VAL B 2 187 ? 163.403 187.304 193.488 1.00 51.54  ? 187 VAL C O   1 
ATOM   3556 C CB  . VAL B 2 187 ? 164.227 188.731 196.046 1.00 51.54  ? 187 VAL C CB  1 
ATOM   3557 C CG1 . VAL B 2 187 ? 165.281 187.765 196.529 1.00 51.54  ? 187 VAL C CG1 1 
ATOM   3558 C CG2 . VAL B 2 187 ? 164.137 189.955 196.929 1.00 51.54  ? 187 VAL C CG2 1 
ATOM   3559 N N   . MET B 2 188 ? 165.626 187.544 193.136 1.00 51.41  ? 188 MET C N   1 
ATOM   3560 C CA  . MET B 2 188 ? 165.750 186.331 192.335 1.00 51.41  ? 188 MET C CA  1 
ATOM   3561 C C   . MET B 2 188 ? 167.049 185.580 192.625 1.00 51.41  ? 188 MET C C   1 
ATOM   3562 O O   . MET B 2 188 ? 167.581 184.882 191.755 1.00 51.41  ? 188 MET C O   1 
ATOM   3563 C CB  . MET B 2 188 ? 165.593 186.650 190.845 1.00 51.41  ? 188 MET C CB  1 
ATOM   3564 C CG  . MET B 2 188 ? 166.682 187.507 190.249 1.00 51.41  ? 188 MET C CG  1 
ATOM   3565 S SD  . MET B 2 188 ? 166.495 189.178 190.865 1.00 51.41  ? 188 MET C SD  1 
ATOM   3566 C CE  . MET B 2 188 ? 164.981 189.636 190.039 1.00 51.41  ? 188 MET C CE  1 
ATOM   3567 N N   . SER B 2 189 ? 167.545 185.671 193.855 1.00 50.07  ? 189 SER C N   1 
ATOM   3568 C CA  . SER B 2 189 ? 168.747 184.952 194.240 1.00 50.07  ? 189 SER C CA  1 
ATOM   3569 C C   . SER B 2 189 ? 168.569 184.394 195.644 1.00 50.07  ? 189 SER C C   1 
ATOM   3570 O O   . SER B 2 189 ? 168.024 185.060 196.528 1.00 50.07  ? 189 SER C O   1 
ATOM   3571 C CB  . SER B 2 189 ? 169.969 185.863 194.174 1.00 50.07  ? 189 SER C CB  1 
ATOM   3572 O OG  . SER B 2 189 ? 170.128 186.377 192.868 1.00 50.07  ? 189 SER C OG  1 
ATOM   3573 N N   . LEU B 2 190 ? 169.040 183.164 195.841 1.00 46.40  ? 190 LEU C N   1 
ATOM   3574 C CA  . LEU B 2 190 ? 168.974 182.505 197.138 1.00 46.40  ? 190 LEU C CA  1 
ATOM   3575 C C   . LEU B 2 190 ? 170.038 181.425 197.191 1.00 46.40  ? 190 LEU C C   1 
ATOM   3576 O O   . LEU B 2 190 ? 170.174 180.637 196.253 1.00 46.40  ? 190 LEU C O   1 
ATOM   3577 C CB  . LEU B 2 190 ? 167.593 181.891 197.385 1.00 46.40  ? 190 LEU C CB  1 
ATOM   3578 C CG  . LEU B 2 190 ? 167.213 181.447 198.793 1.00 46.40  ? 190 LEU C CG  1 
ATOM   3579 C CD1 . LEU B 2 190 ? 166.942 182.641 199.665 1.00 46.40  ? 190 LEU C CD1 1 
ATOM   3580 C CD2 . LEU B 2 190 ? 166.001 180.551 198.723 1.00 46.40  ? 190 LEU C CD2 1 
ATOM   3581 N N   . SER B 2 191 ? 170.787 181.400 198.288 1.00 47.09  ? 191 SER C N   1 
ATOM   3582 C CA  . SER B 2 191 ? 171.801 180.379 198.508 1.00 47.09  ? 191 SER C CA  1 
ATOM   3583 C C   . SER B 2 191 ? 171.898 180.129 200.001 1.00 47.09  ? 191 SER C C   1 
ATOM   3584 O O   . SER B 2 191 ? 171.986 181.082 200.777 1.00 47.09  ? 191 SER C O   1 
ATOM   3585 C CB  . SER B 2 191 ? 173.156 180.813 197.955 1.00 47.09  ? 191 SER C CB  1 
ATOM   3586 O OG  . SER B 2 191 ? 174.189 179.950 198.392 1.00 47.09  ? 191 SER C OG  1 
ATOM   3587 N N   . LEU B 2 192 ? 171.885 178.863 200.395 1.00 46.89  ? 192 LEU C N   1 
ATOM   3588 C CA  . LEU B 2 192 ? 171.955 178.498 201.799 1.00 46.89  ? 192 LEU C CA  1 
ATOM   3589 C C   . LEU B 2 192 ? 173.378 178.125 202.182 1.00 46.89  ? 192 LEU C C   1 
ATOM   3590 O O   . LEU B 2 192 ? 174.147 177.608 201.368 1.00 46.89  ? 192 LEU C O   1 
ATOM   3591 C CB  . LEU B 2 192 ? 171.019 177.332 202.099 1.00 46.89  ? 192 LEU C CB  1 
ATOM   3592 C CG  . LEU B 2 192 ? 169.570 177.530 201.671 1.00 46.89  ? 192 LEU C CG  1 
ATOM   3593 C CD1 . LEU B 2 192 ? 168.902 176.205 201.563 1.00 46.89  ? 192 LEU C CD1 1 
ATOM   3594 C CD2 . LEU B 2 192 ? 168.848 178.366 202.696 1.00 46.89  ? 192 LEU C CD2 1 
ATOM   3595 N N   . ALA B 2 193 ? 173.724 178.409 203.431 1.00 51.77  ? 193 ALA C N   1 
ATOM   3596 C CA  . ALA B 2 193 ? 175.054 178.106 203.922 1.00 51.77  ? 193 ALA C CA  1 
ATOM   3597 C C   . ALA B 2 193 ? 175.227 176.596 204.083 1.00 51.77  ? 193 ALA C C   1 
ATOM   3598 O O   . ALA B 2 193 ? 174.255 175.880 204.340 1.00 51.77  ? 193 ALA C O   1 
ATOM   3599 C CB  . ALA B 2 193 ? 175.301 178.814 205.250 1.00 51.77  ? 193 ALA C CB  1 
ATOM   3600 N N   . PRO B 2 194 ? 176.452 176.086 203.902 1.00 57.86  ? 194 PRO C N   1 
ATOM   3601 C CA  . PRO B 2 194 ? 176.678 174.637 204.058 1.00 57.86  ? 194 PRO C CA  1 
ATOM   3602 C C   . PRO B 2 194 ? 176.379 174.109 205.450 1.00 57.86  ? 194 PRO C C   1 
ATOM   3603 O O   . PRO B 2 194 ? 175.998 172.940 205.587 1.00 57.86  ? 194 PRO C O   1 
ATOM   3604 C CB  . PRO B 2 194 ? 178.164 174.476 203.706 1.00 57.86  ? 194 PRO C CB  1 
ATOM   3605 C CG  . PRO B 2 194 ? 178.486 175.659 202.862 1.00 57.86  ? 194 PRO C CG  1 
ATOM   3606 C CD  . PRO B 2 194 ? 177.655 176.777 203.403 1.00 57.86  ? 194 PRO C CD  1 
ATOM   3607 N N   . ASP B 2 195 ? 176.531 174.929 206.487 1.00 59.96  ? 195 ASP C N   1 
ATOM   3608 C CA  . ASP B 2 195 ? 176.226 174.504 207.845 1.00 59.96  ? 195 ASP C CA  1 
ATOM   3609 C C   . ASP B 2 195 ? 174.748 174.642 208.188 1.00 59.96  ? 195 ASP C C   1 
ATOM   3610 O O   . ASP B 2 195 ? 174.364 174.316 209.318 1.00 59.96  ? 195 ASP C O   1 
ATOM   3611 C CB  . ASP B 2 195 ? 177.077 175.288 208.852 1.00 59.96  ? 195 ASP C CB  1 
ATOM   3612 C CG  . ASP B 2 195 ? 176.654 176.734 208.975 1.00 59.96  ? 195 ASP C CG  1 
ATOM   3613 O OD1 . ASP B 2 195 ? 176.301 177.340 207.947 1.00 59.96  ? 195 ASP C OD1 1 
ATOM   3614 O OD2 . ASP B 2 195 ? 176.685 177.270 210.102 1.00 59.96  ? 195 ASP C OD2 1 
ATOM   3615 N N   . THR B 2 196 ? 173.933 175.126 207.243 1.00 59.28  ? 196 THR C N   1 
ATOM   3616 C CA  . THR B 2 196 ? 172.469 175.172 207.336 1.00 59.28  ? 196 THR C CA  1 
ATOM   3617 C C   . THR B 2 196 ? 172.034 176.011 208.545 1.00 59.28  ? 196 THR C C   1 
ATOM   3618 O O   . THR B 2 196 ? 171.227 175.606 209.385 1.00 59.28  ? 196 THR C O   1 
ATOM   3619 C CB  . THR B 2 196 ? 171.892 173.747 207.367 1.00 59.28  ? 196 THR C CB  1 
ATOM   3620 O OG1 . THR B 2 196 ? 172.550 172.958 206.370 1.00 59.28  ? 196 THR C OG1 1 
ATOM   3621 C CG2 . THR B 2 196 ? 170.409 173.738 207.017 1.00 59.28  ? 196 THR C CG2 1 
ATOM   3622 N N   . ARG B 2 197 ? 172.620 177.186 208.633 1.00 61.68  ? 197 ARG C N   1 
ATOM   3623 C CA  . ARG B 2 197 ? 172.346 178.122 209.715 1.00 61.68  ? 197 ARG C CA  1 
ATOM   3624 C C   . ARG B 2 197 ? 171.969 179.500 209.198 1.00 61.68  ? 197 ARG C C   1 
ATOM   3625 O O   . ARG B 2 197 ? 171.126 180.171 209.798 1.00 61.68  ? 197 ARG C O   1 
ATOM   3626 C CB  . ARG B 2 197 ? 173.579 178.230 210.634 1.00 61.68  ? 197 ARG C CB  1 
ATOM   3627 C CG  . ARG B 2 197 ? 173.393 179.095 211.874 1.00 61.68  ? 197 ARG C CG  1 
ATOM   3628 C CD  . ARG B 2 197 ? 172.687 178.330 212.987 1.00 61.68  ? 197 ARG C CD  1 
ATOM   3629 N NE  . ARG B 2 197 ? 171.234 178.376 212.888 1.00 61.68  ? 197 ARG C NE  1 
ATOM   3630 C CZ  . ARG B 2 197 ? 170.415 177.637 213.625 1.00 61.68  ? 197 ARG C CZ  1 
ATOM   3631 N NH1 . ARG B 2 197 ? 170.875 176.803 214.542 1.00 61.68  ? 197 ARG C NH1 1 
ATOM   3632 N NH2 . ARG B 2 197 ? 169.103 177.736 213.434 1.00 61.68  ? 197 ARG C NH2 1 
ATOM   3633 N N   . LEU B 2 198 ? 172.567 179.933 208.091 1.00 55.24  ? 198 LEU C N   1 
ATOM   3634 C CA  . LEU B 2 198 ? 172.344 181.249 207.518 1.00 55.24  ? 198 LEU C CA  1 
ATOM   3635 C C   . LEU B 2 198 ? 172.084 181.108 206.027 1.00 55.24  ? 198 LEU C C   1 
ATOM   3636 O O   . LEU B 2 198 ? 172.256 180.035 205.445 1.00 55.24  ? 198 LEU C O   1 
ATOM   3637 C CB  . LEU B 2 198 ? 173.548 182.167 207.750 1.00 55.24  ? 198 LEU C CB  1 
ATOM   3638 C CG  . LEU B 2 198 ? 174.051 182.331 209.181 1.00 55.24  ? 198 LEU C CG  1 
ATOM   3639 C CD1 . LEU B 2 198 ? 175.492 182.798 209.179 1.00 55.24  ? 198 LEU C CD1 1 
ATOM   3640 C CD2 . LEU B 2 198 ? 173.170 183.294 209.953 1.00 55.24  ? 198 LEU C CD2 1 
ATOM   3641 N N   . PHE B 2 199 ? 171.661 182.205 205.406 1.00 50.40  ? 199 PHE C N   1 
ATOM   3642 C CA  . PHE B 2 199 ? 171.578 182.244 203.953 1.00 50.40  ? 199 PHE C CA  1 
ATOM   3643 C C   . PHE B 2 199 ? 171.713 183.678 203.479 1.00 50.40  ? 199 PHE C C   1 
ATOM   3644 O O   . PHE B 2 199 ? 171.415 184.627 204.208 1.00 50.40  ? 199 PHE C O   1 
ATOM   3645 C CB  . PHE B 2 199 ? 170.281 181.615 203.428 1.00 50.40  ? 199 PHE C CB  1 
ATOM   3646 C CG  . PHE B 2 199 ? 169.031 182.394 203.731 1.00 50.40  ? 199 PHE C CG  1 
ATOM   3647 C CD1 . PHE B 2 199 ? 168.371 182.223 204.931 1.00 50.40  ? 199 PHE C CD1 1 
ATOM   3648 C CD2 . PHE B 2 199 ? 168.483 183.251 202.792 1.00 50.40  ? 199 PHE C CD2 1 
ATOM   3649 C CE1 . PHE B 2 199 ? 167.209 182.911 205.202 1.00 50.40  ? 199 PHE C CE1 1 
ATOM   3650 C CE2 . PHE B 2 199 ? 167.322 183.944 203.060 1.00 50.40  ? 199 PHE C CE2 1 
ATOM   3651 C CZ  . PHE B 2 199 ? 166.684 183.773 204.265 1.00 50.40  ? 199 PHE C CZ  1 
ATOM   3652 N N   . VAL B 2 200 ? 172.156 183.818 202.236 1.00 49.62  ? 200 VAL C N   1 
ATOM   3653 C CA  . VAL B 2 200 ? 172.258 185.117 201.597 1.00 49.62  ? 200 VAL C CA  1 
ATOM   3654 C C   . VAL B 2 200 ? 171.270 185.148 200.443 1.00 49.62  ? 200 VAL C C   1 
ATOM   3655 O O   . VAL B 2 200 ? 170.900 184.116 199.877 1.00 49.62  ? 200 VAL C O   1 
ATOM   3656 C CB  . VAL B 2 200 ? 173.686 185.430 201.102 1.00 49.62  ? 200 VAL C CB  1 
ATOM   3657 C CG1 . VAL B 2 200 ? 174.629 185.607 202.280 1.00 49.62  ? 200 VAL C CG1 1 
ATOM   3658 C CG2 . VAL B 2 200 ? 174.184 184.347 200.164 1.00 49.62  ? 200 VAL C CG2 1 
ATOM   3659 N N   . SER B 2 201 ? 170.827 186.354 200.108 1.00 47.69  ? 201 SER C N   1 
ATOM   3660 C CA  . SER B 2 201 ? 169.892 186.535 199.013 1.00 47.69  ? 201 SER C CA  1 
ATOM   3661 C C   . SER B 2 201 ? 170.238 187.829 198.300 1.00 47.69  ? 201 SER C C   1 
ATOM   3662 O O   . SER B 2 201 ? 170.602 188.815 198.942 1.00 47.69  ? 201 SER C O   1 
ATOM   3663 C CB  . SER B 2 201 ? 168.449 186.562 199.517 1.00 47.69  ? 201 SER C CB  1 
ATOM   3664 O OG  . SER B 2 201 ? 167.541 186.362 198.454 1.00 47.69  ? 201 SER C OG  1 
ATOM   3665 N N   . GLY B 2 202 ? 170.133 187.818 196.976 1.00 54.24  ? 202 GLY C N   1 
ATOM   3666 C CA  . GLY B 2 202 ? 170.384 188.994 196.164 1.00 54.24  ? 202 GLY C CA  1 
ATOM   3667 C C   . GLY B 2 202 ? 169.089 189.505 195.562 1.00 54.24  ? 202 GLY C C   1 
ATOM   3668 O O   . GLY B 2 202 ? 168.176 188.728 195.277 1.00 54.24  ? 202 GLY C O   1 
ATOM   3669 N N   . ALA B 2 203 ? 169.015 190.819 195.358 1.00 56.68  ? 203 ALA C N   1 
ATOM   3670 C CA  . ALA B 2 203 ? 167.791 191.455 194.896 1.00 56.68  ? 203 ALA C CA  1 
ATOM   3671 C C   . ALA B 2 203 ? 168.127 192.463 193.804 1.00 56.68  ? 203 ALA C C   1 
ATOM   3672 O O   . ALA B 2 203 ? 169.287 192.625 193.413 1.00 56.68  ? 203 ALA C O   1 
ATOM   3673 C CB  . ALA B 2 203 ? 167.044 192.120 196.056 1.00 56.68  ? 203 ALA C CB  1 
ATOM   3674 N N   . CYS B 2 204 ? 167.091 193.148 193.306 1.00 60.34  ? 204 CYS C N   1 
ATOM   3675 C CA  . CYS B 2 204 ? 167.267 194.102 192.214 1.00 60.34  ? 204 CYS C CA  1 
ATOM   3676 C C   . CYS B 2 204 ? 167.992 195.371 192.638 1.00 60.34  ? 204 CYS C C   1 
ATOM   3677 O O   . CYS B 2 204 ? 168.533 196.074 191.778 1.00 60.34  ? 204 CYS C O   1 
ATOM   3678 C CB  . CYS B 2 204 ? 165.916 194.482 191.609 1.00 60.34  ? 204 CYS C CB  1 
ATOM   3679 S SG  . CYS B 2 204 ? 165.146 193.220 190.585 1.00 60.34  ? 204 CYS C SG  1 
ATOM   3680 N N   . ASP B 2 205 ? 168.022 195.687 193.928 1.00 63.02  ? 205 ASP C N   1 
ATOM   3681 C CA  . ASP B 2 205 ? 168.661 196.911 194.389 1.00 63.02  ? 205 ASP C CA  1 
ATOM   3682 C C   . ASP B 2 205 ? 170.153 196.742 194.643 1.00 63.02  ? 205 ASP C C   1 
ATOM   3683 O O   . ASP B 2 205 ? 170.710 197.510 195.440 1.00 63.02  ? 205 ASP C O   1 
ATOM   3684 C CB  . ASP B 2 205 ? 167.967 197.426 195.653 1.00 63.02  ? 205 ASP C CB  1 
ATOM   3685 C CG  . ASP B 2 205 ? 167.738 196.336 196.682 1.00 63.02  ? 205 ASP C CG  1 
ATOM   3686 O OD1 . ASP B 2 205 ? 168.187 195.194 196.457 1.00 63.02  ? 205 ASP C OD1 1 
ATOM   3687 O OD2 . ASP B 2 205 ? 167.106 196.623 197.720 1.00 63.02  ? 205 ASP C OD2 1 
ATOM   3688 N N   . ALA B 2 206 ? 170.783 195.758 193.990 1.00 60.40  ? 206 ALA C N   1 
ATOM   3689 C CA  . ALA B 2 206 ? 172.208 195.449 194.127 1.00 60.40  ? 206 ALA C CA  1 
ATOM   3690 C C   . ALA B 2 206 ? 172.595 195.161 195.575 1.00 60.40  ? 206 ALA C C   1 
ATOM   3691 O O   . ALA B 2 206 ? 173.676 195.540 196.027 1.00 60.40  ? 206 ALA C O   1 
ATOM   3692 C CB  . ALA B 2 206 ? 173.085 196.565 193.549 1.00 60.40  ? 206 ALA C CB  1 
ATOM   3693 N N   . SER B 2 207 ? 171.721 194.476 196.307 1.00 57.82  ? 207 SER C N   1 
ATOM   3694 C CA  . SER B 2 207 ? 171.898 194.255 197.735 1.00 57.82  ? 207 SER C CA  1 
ATOM   3695 C C   . SER B 2 207 ? 171.942 192.764 198.030 1.00 57.82  ? 207 SER C C   1 
ATOM   3696 O O   . SER B 2 207 ? 171.060 192.016 197.598 1.00 57.82  ? 207 SER C O   1 
ATOM   3697 C CB  . SER B 2 207 ? 170.771 194.918 198.532 1.00 57.82  ? 207 SER C CB  1 
ATOM   3698 O OG  . SER B 2 207 ? 169.603 194.119 198.518 1.00 57.82  ? 207 SER C OG  1 
ATOM   3699 N N   . ALA B 2 208 ? 172.967 192.339 198.763 1.00 51.76  ? 208 ALA C N   1 
ATOM   3700 C CA  . ALA B 2 208 ? 173.085 190.970 199.244 1.00 51.76  ? 208 ALA C CA  1 
ATOM   3701 C C   . ALA B 2 208 ? 172.955 190.979 200.760 1.00 51.76  ? 208 ALA C C   1 
ATOM   3702 O O   . ALA B 2 208 ? 173.808 191.542 201.453 1.00 51.76  ? 208 ALA C O   1 
ATOM   3703 C CB  . ALA B 2 208 ? 174.412 190.354 198.815 1.00 51.76  ? 208 ALA C CB  1 
ATOM   3704 N N   . LYS B 2 209 ? 171.898 190.353 201.270 1.00 52.89  ? 209 LYS C N   1 
ATOM   3705 C CA  . LYS B 2 209 ? 171.552 190.408 202.685 1.00 52.89  ? 209 LYS C CA  1 
ATOM   3706 C C   . LYS B 2 209 ? 171.740 189.048 203.338 1.00 52.89  ? 209 LYS C C   1 
ATOM   3707 O O   . LYS B 2 209 ? 171.265 188.032 202.821 1.00 52.89  ? 209 LYS C O   1 
ATOM   3708 C CB  . LYS B 2 209 ? 170.109 190.876 202.885 1.00 52.89  ? 209 LYS C CB  1 
ATOM   3709 C CG  . LYS B 2 209 ? 169.890 192.353 202.645 1.00 52.89  ? 209 LYS C CG  1 
ATOM   3710 C CD  . LYS B 2 209 ? 168.555 192.793 203.204 1.00 52.89  ? 209 LYS C CD  1 
ATOM   3711 C CE  . LYS B 2 209 ? 168.325 194.269 202.967 1.00 52.89  ? 209 LYS C CE  1 
ATOM   3712 N NZ  . LYS B 2 209 ? 169.331 195.099 203.674 1.00 52.89  ? 209 LYS C NZ  1 
ATOM   3713 N N   . LEU B 2 210 ? 172.416 189.042 204.482 1.00 53.23  ? 210 LEU C N   1 
ATOM   3714 C CA  . LEU B 2 210 ? 172.603 187.842 205.282 1.00 53.23  ? 210 LEU C CA  1 
ATOM   3715 C C   . LEU B 2 210 ? 171.461 187.701 206.278 1.00 53.23  ? 210 LEU C C   1 
ATOM   3716 O O   . LEU B 2 210 ? 171.179 188.629 207.040 1.00 53.23  ? 210 LEU C O   1 
ATOM   3717 C CB  . LEU B 2 210 ? 173.935 187.905 206.024 1.00 53.23  ? 210 LEU C CB  1 
ATOM   3718 C CG  . LEU B 2 210 ? 174.129 186.810 207.067 1.00 53.23  ? 210 LEU C CG  1 
ATOM   3719 C CD1 . LEU B 2 210 ? 174.157 185.459 206.384 1.00 53.23  ? 210 LEU C CD1 1 
ATOM   3720 C CD2 . LEU B 2 210 ? 175.391 187.049 207.880 1.00 53.23  ? 210 LEU C CD2 1 
ATOM   3721 N N   . TRP B 2 211 ? 170.821 186.539 206.283 1.00 51.95  ? 211 TRP C N   1 
ATOM   3722 C CA  . TRP B 2 211 ? 169.705 186.279 207.174 1.00 51.95  ? 211 TRP C CA  1 
ATOM   3723 C C   . TRP B 2 211 ? 169.995 185.060 208.039 1.00 51.95  ? 211 TRP C C   1 
ATOM   3724 O O   . TRP B 2 211 ? 170.689 184.128 207.625 1.00 51.95  ? 211 TRP C O   1 
ATOM   3725 C CB  . TRP B 2 211 ? 168.410 186.042 206.392 1.00 51.95  ? 211 TRP C CB  1 
ATOM   3726 C CG  . TRP B 2 211 ? 168.094 187.079 205.363 1.00 51.95  ? 211 TRP C CG  1 
ATOM   3727 C CD1 . TRP B 2 211 ? 168.567 187.134 204.086 1.00 51.95  ? 211 TRP C CD1 1 
ATOM   3728 C CD2 . TRP B 2 211 ? 167.202 188.190 205.508 1.00 51.95  ? 211 TRP C CD2 1 
ATOM   3729 N NE1 . TRP B 2 211 ? 168.044 188.222 203.433 1.00 51.95  ? 211 TRP C NE1 1 
ATOM   3730 C CE2 . TRP B 2 211 ? 167.201 188.886 204.284 1.00 51.95  ? 211 TRP C CE2 1 
ATOM   3731 C CE3 . TRP B 2 211 ? 166.417 188.672 206.558 1.00 51.95  ? 211 TRP C CE3 1 
ATOM   3732 C CZ2 . TRP B 2 211 ? 166.443 190.031 204.080 1.00 51.95  ? 211 TRP C CZ2 1 
ATOM   3733 C CZ3 . TRP B 2 211 ? 165.664 189.809 206.352 1.00 51.95  ? 211 TRP C CZ3 1 
ATOM   3734 C CH2 . TRP B 2 211 ? 165.684 190.477 205.123 1.00 51.95  ? 211 TRP C CH2 1 
ATOM   3735 N N   . ASP B 2 212 ? 169.446 185.073 209.247 1.00 59.12  ? 212 ASP C N   1 
ATOM   3736 C CA  . ASP B 2 212 ? 169.463 183.923 210.136 1.00 59.12  ? 212 ASP C CA  1 
ATOM   3737 C C   . ASP B 2 212 ? 168.097 183.255 210.096 1.00 59.12  ? 212 ASP C C   1 
ATOM   3738 O O   . ASP B 2 212 ? 167.067 183.936 210.096 1.00 59.12  ? 212 ASP C O   1 
ATOM   3739 C CB  . ASP B 2 212 ? 169.808 184.339 211.566 1.00 59.12  ? 212 ASP C CB  1 
ATOM   3740 C CG  . ASP B 2 212 ? 170.158 183.157 212.448 1.00 59.12  ? 212 ASP C CG  1 
ATOM   3741 O OD1 . ASP B 2 212 ? 170.463 182.076 211.904 1.00 59.12  ? 212 ASP C OD1 1 
ATOM   3742 O OD2 . ASP B 2 212 ? 170.129 183.310 213.687 1.00 59.12  ? 212 ASP C OD2 1 
ATOM   3743 N N   . VAL B 2 213 ? 168.085 181.923 210.061 1.00 59.20  ? 213 VAL C N   1 
ATOM   3744 C CA  . VAL B 2 213 ? 166.825 181.227 209.817 1.00 59.20  ? 213 VAL C CA  1 
ATOM   3745 C C   . VAL B 2 213 ? 166.032 180.999 211.101 1.00 59.20  ? 213 VAL C C   1 
ATOM   3746 O O   . VAL B 2 213 ? 164.801 180.894 211.055 1.00 59.20  ? 213 VAL C O   1 
ATOM   3747 C CB  . VAL B 2 213 ? 167.074 179.900 209.081 1.00 59.20  ? 213 VAL C CB  1 
ATOM   3748 C CG1 . VAL B 2 213 ? 167.608 180.166 207.696 1.00 59.20  ? 213 VAL C CG1 1 
ATOM   3749 C CG2 . VAL B 2 213 ? 168.034 179.021 209.864 1.00 59.20  ? 213 VAL C CG2 1 
ATOM   3750 N N   . ARG B 2 214 ? 166.695 180.914 212.256 1.00 65.09  ? 214 ARG C N   1 
ATOM   3751 C CA  . ARG B 2 214 ? 165.986 180.565 213.483 1.00 65.09  ? 214 ARG C CA  1 
ATOM   3752 C C   . ARG B 2 214 ? 165.181 181.721 214.059 1.00 65.09  ? 214 ARG C C   1 
ATOM   3753 O O   . ARG B 2 214 ? 164.264 181.482 214.853 1.00 65.09  ? 214 ARG C O   1 
ATOM   3754 C CB  . ARG B 2 214 ? 166.964 180.062 214.544 1.00 65.09  ? 214 ARG C CB  1 
ATOM   3755 C CG  . ARG B 2 214 ? 167.977 181.095 215.003 1.00 65.09  ? 214 ARG C CG  1 
ATOM   3756 C CD  . ARG B 2 214 ? 168.468 180.782 216.404 1.00 65.09  ? 214 ARG C CD  1 
ATOM   3757 N NE  . ARG B 2 214 ? 169.192 179.518 216.456 1.00 65.09  ? 214 ARG C NE  1 
ATOM   3758 C CZ  . ARG B 2 214 ? 169.582 178.925 217.576 1.00 65.09  ? 214 ARG C CZ  1 
ATOM   3759 N NH1 . ARG B 2 214 ? 169.350 179.465 218.761 1.00 65.09  ? 214 ARG C NH1 1 
ATOM   3760 N NH2 . ARG B 2 214 ? 170.220 177.761 217.505 1.00 65.09  ? 214 ARG C NH2 1 
ATOM   3761 N N   . GLU B 2 215 ? 165.503 182.958 213.690 1.00 63.81  ? 215 GLU C N   1 
ATOM   3762 C CA  . GLU B 2 215 ? 164.847 184.114 214.285 1.00 63.81  ? 215 GLU C CA  1 
ATOM   3763 C C   . GLU B 2 215 ? 164.403 185.120 213.229 1.00 63.81  ? 215 GLU C C   1 
ATOM   3764 O O   . GLU B 2 215 ? 163.456 185.881 213.454 1.00 63.81  ? 215 GLU C O   1 
ATOM   3765 C CB  . GLU B 2 215 ? 165.773 184.748 215.324 1.00 63.81  ? 215 GLU C CB  1 
ATOM   3766 C CG  . GLU B 2 215 ? 167.170 185.053 214.821 1.00 63.81  ? 215 GLU C CG  1 
ATOM   3767 C CD  . GLU B 2 215 ? 167.285 186.433 214.234 1.00 63.81  ? 215 GLU C CD  1 
ATOM   3768 O OE1 . GLU B 2 215 ? 166.422 187.276 214.552 1.00 63.81  ? 215 GLU C OE1 1 
ATOM   3769 O OE2 . GLU B 2 215 ? 168.235 186.672 213.458 1.00 63.81  ? 215 GLU C OE2 1 
ATOM   3770 N N   . GLY B 2 216 ? 165.081 185.145 212.084 1.00 61.09  ? 216 GLY C N   1 
ATOM   3771 C CA  . GLY B 2 216 ? 164.584 185.882 210.937 1.00 61.09  ? 216 GLY C CA  1 
ATOM   3772 C C   . GLY B 2 216 ? 164.802 187.382 210.910 1.00 61.09  ? 216 GLY C C   1 
ATOM   3773 O O   . GLY B 2 216 ? 163.830 188.141 210.934 1.00 61.09  ? 216 GLY C O   1 
ATOM   3774 N N   . MET B 2 217 ? 166.054 187.833 210.863 1.00 59.96  ? 217 MET C N   1 
ATOM   3775 C CA  . MET B 2 217 ? 166.319 189.240 210.587 1.00 59.96  ? 217 MET C CA  1 
ATOM   3776 C C   . MET B 2 217 ? 167.616 189.352 209.799 1.00 59.96  ? 217 MET C C   1 
ATOM   3777 O O   . MET B 2 217 ? 168.447 188.441 209.802 1.00 59.96  ? 217 MET C O   1 
ATOM   3778 C CB  . MET B 2 217 ? 166.373 190.088 211.871 1.00 59.96  ? 217 MET C CB  1 
ATOM   3779 C CG  . MET B 2 217 ? 167.511 189.809 212.849 1.00 59.96  ? 217 MET C CG  1 
ATOM   3780 S SD  . MET B 2 217 ? 168.978 190.822 212.569 1.00 59.96  ? 217 MET C SD  1 
ATOM   3781 C CE  . MET B 2 217 ? 168.393 192.428 213.112 1.00 59.96  ? 217 MET C CE  1 
ATOM   3782 N N   . CYS B 2 218 ? 167.774 190.481 209.113 1.00 56.57  ? 218 CYS C N   1 
ATOM   3783 C CA  . CYS B 2 218 ? 168.948 190.711 208.281 1.00 56.57  ? 218 CYS C CA  1 
ATOM   3784 C C   . CYS B 2 218 ? 170.142 191.102 209.141 1.00 56.57  ? 218 CYS C C   1 
ATOM   3785 O O   . CYS B 2 218 ? 170.116 192.132 209.822 1.00 56.57  ? 218 CYS C O   1 
ATOM   3786 C CB  . CYS B 2 218 ? 168.656 191.795 207.250 1.00 56.57  ? 218 CYS C CB  1 
ATOM   3787 S SG  . CYS B 2 218 ? 170.131 192.461 206.450 1.00 56.57  ? 218 CYS C SG  1 
ATOM   3788 N N   . ARG B 2 219 ? 171.199 190.288 209.101 1.00 56.68  ? 219 ARG C N   1 
ATOM   3789 C CA  . ARG B 2 219 ? 172.348 190.543 209.965 1.00 56.68  ? 219 ARG C CA  1 
ATOM   3790 C C   . ARG B 2 219 ? 173.358 191.485 209.319 1.00 56.68  ? 219 ARG C C   1 
ATOM   3791 O O   . ARG B 2 219 ? 173.903 192.363 209.994 1.00 56.68  ? 219 ARG C O   1 
ATOM   3792 C CB  . ARG B 2 219 ? 173.003 189.220 210.369 1.00 56.68  ? 219 ARG C CB  1 
ATOM   3793 C CG  . ARG B 2 219 ? 172.133 188.381 211.301 1.00 56.68  ? 219 ARG C CG  1 
ATOM   3794 C CD  . ARG B 2 219 ? 172.881 187.177 211.847 1.00 56.68  ? 219 ARG C CD  1 
ATOM   3795 N NE  . ARG B 2 219 ? 174.014 187.578 212.672 1.00 56.68  ? 219 ARG C NE  1 
ATOM   3796 C CZ  . ARG B 2 219 ? 175.281 187.332 212.376 1.00 56.68  ? 219 ARG C CZ  1 
ATOM   3797 N NH1 . ARG B 2 219 ? 175.618 186.665 211.285 1.00 56.68  ? 219 ARG C NH1 1 
ATOM   3798 N NH2 . ARG B 2 219 ? 176.234 187.762 213.197 1.00 56.68  ? 219 ARG C NH2 1 
ATOM   3799 N N   . GLN B 2 220 ? 173.607 191.341 208.021 1.00 57.32  ? 220 GLN C N   1 
ATOM   3800 C CA  . GLN B 2 220 ? 174.494 192.247 207.302 1.00 57.32  ? 220 GLN C CA  1 
ATOM   3801 C C   . GLN B 2 220 ? 173.945 192.474 205.903 1.00 57.32  ? 220 GLN C C   1 
ATOM   3802 O O   . GLN B 2 220 ? 173.236 191.626 205.357 1.00 57.32  ? 220 GLN C O   1 
ATOM   3803 C CB  . GLN B 2 220 ? 175.934 191.711 207.188 1.00 57.32  ? 220 GLN C CB  1 
ATOM   3804 C CG  . GLN B 2 220 ? 176.719 191.617 208.482 1.00 57.32  ? 220 GLN C CG  1 
ATOM   3805 C CD  . GLN B 2 220 ? 178.113 191.060 208.259 1.00 57.32  ? 220 GLN C CD  1 
ATOM   3806 O OE1 . GLN B 2 220 ? 178.477 190.681 207.157 1.00 57.32  ? 220 GLN C OE1 1 
ATOM   3807 N NE2 . GLN B 2 220 ? 178.903 190.996 209.330 1.00 57.32  ? 220 GLN C NE2 1 
ATOM   3808 N N   . THR B 2 221 ? 174.283 193.626 205.325 1.00 63.25  ? 221 THR C N   1 
ATOM   3809 C CA  . THR B 2 221 ? 173.995 193.864 203.918 1.00 63.25  ? 221 THR C CA  1 
ATOM   3810 C C   . THR B 2 221 ? 175.156 194.630 203.308 1.00 63.25  ? 221 THR C C   1 
ATOM   3811 O O   . THR B 2 221 ? 175.935 195.283 204.008 1.00 63.25  ? 221 THR C O   1 
ATOM   3812 C CB  . THR B 2 221 ? 172.683 194.629 203.698 1.00 63.25  ? 221 THR C CB  1 
ATOM   3813 O OG1 . THR B 2 221 ? 172.345 194.596 202.307 1.00 63.25  ? 221 THR C OG1 1 
ATOM   3814 C CG2 . THR B 2 221 ? 172.817 196.078 204.134 1.00 63.25  ? 221 THR C CG2 1 
ATOM   3815 N N   . PHE B 2 222 ? 175.274 194.529 201.989 1.00 75.00  ? 222 PHE C N   1 
ATOM   3816 C CA  . PHE B 2 222 ? 176.347 195.208 201.281 1.00 75.00  ? 222 PHE C CA  1 
ATOM   3817 C C   . PHE B 2 222 ? 175.934 195.438 199.838 1.00 75.00  ? 222 PHE C C   1 
ATOM   3818 O O   . PHE B 2 222 ? 175.351 194.558 199.199 1.00 75.00  ? 222 PHE C O   1 
ATOM   3819 C CB  . PHE B 2 222 ? 177.656 194.410 201.326 1.00 75.00  ? 222 PHE C CB  1 
ATOM   3820 C CG  . PHE B 2 222 ? 178.815 195.115 200.678 1.00 75.00  ? 222 PHE C CG  1 
ATOM   3821 C CD1 . PHE B 2 222 ? 179.278 196.316 201.191 1.00 75.00  ? 222 PHE C CD1 1 
ATOM   3822 C CD2 . PHE B 2 222 ? 179.445 194.579 199.565 1.00 75.00  ? 222 PHE C CD2 1 
ATOM   3823 C CE1 . PHE B 2 222 ? 180.343 196.973 200.608 1.00 75.00  ? 222 PHE C CE1 1 
ATOM   3824 C CE2 . PHE B 2 222 ? 180.515 195.235 198.976 1.00 75.00  ? 222 PHE C CE2 1 
ATOM   3825 C CZ  . PHE B 2 222 ? 180.962 196.432 199.500 1.00 75.00  ? 222 PHE C CZ  1 
ATOM   3826 N N   . THR B 2 223 ? 176.258 196.624 199.333 1.00 71.08  ? 223 THR C N   1 
ATOM   3827 C CA  . THR B 2 223 ? 175.939 197.024 197.970 1.00 71.08  ? 223 THR C CA  1 
ATOM   3828 C C   . THR B 2 223 ? 177.246 197.351 197.264 1.00 71.08  ? 223 THR C C   1 
ATOM   3829 O O   . THR B 2 223 ? 177.908 198.340 197.597 1.00 71.08  ? 223 THR C O   1 
ATOM   3830 C CB  . THR B 2 223 ? 174.992 198.222 197.957 1.00 71.08  ? 223 THR C CB  1 
ATOM   3831 O OG1 . THR B 2 223 ? 173.759 197.865 198.594 1.00 71.08  ? 223 THR C OG1 1 
ATOM   3832 C CG2 . THR B 2 223 ? 174.705 198.661 196.529 1.00 71.08  ? 223 THR C CG2 1 
ATOM   3833 N N   . GLY B 2 224 ? 177.627 196.509 196.312 1.00 67.92  ? 224 GLY C N   1 
ATOM   3834 C CA  . GLY B 2 224 ? 178.796 196.765 195.500 1.00 67.92  ? 224 GLY C CA  1 
ATOM   3835 C C   . GLY B 2 224 ? 178.453 196.736 194.029 1.00 67.92  ? 224 GLY C C   1 
ATOM   3836 O O   . GLY B 2 224 ? 179.170 197.299 193.198 1.00 67.92  ? 224 GLY C O   1 
ATOM   3837 N N   . HIS B 2 225 ? 177.344 196.084 193.699 1.00 64.56  ? 225 HIS C N   1 
ATOM   3838 C CA  . HIS B 2 225 ? 176.913 196.001 192.317 1.00 64.56  ? 225 HIS C CA  1 
ATOM   3839 C C   . HIS B 2 225 ? 176.172 197.269 191.913 1.00 64.56  ? 225 HIS C C   1 
ATOM   3840 O O   . HIS B 2 225 ? 175.932 198.171 192.720 1.00 64.56  ? 225 HIS C O   1 
ATOM   3841 C CB  . HIS B 2 225 ? 176.012 194.786 192.098 1.00 64.56  ? 225 HIS C CB  1 
ATOM   3842 C CG  . HIS B 2 225 ? 176.762 193.503 191.934 1.00 64.56  ? 225 HIS C CG  1 
ATOM   3843 N ND1 . HIS B 2 225 ? 177.352 193.133 190.746 1.00 64.56  ? 225 HIS C ND1 1 
ATOM   3844 C CD2 . HIS B 2 225 ? 177.007 192.498 192.807 1.00 64.56  ? 225 HIS C CD2 1 
ATOM   3845 C CE1 . HIS B 2 225 ? 177.939 191.959 190.897 1.00 64.56  ? 225 HIS C CE1 1 
ATOM   3846 N NE2 . HIS B 2 225 ? 177.743 191.552 192.138 1.00 64.56  ? 225 HIS C NE2 1 
ATOM   3847 N N   . GLU B 2 226 ? 175.804 197.323 190.633 1.00 67.50  ? 226 GLU C N   1 
ATOM   3848 C CA  . GLU B 2 226 ? 175.081 198.458 190.073 1.00 67.50  ? 226 GLU C CA  1 
ATOM   3849 C C   . GLU B 2 226 ? 173.988 198.008 189.112 1.00 67.50  ? 226 GLU C C   1 
ATOM   3850 O O   . GLU B 2 226 ? 173.478 198.820 188.336 1.00 67.50  ? 226 GLU C O   1 
ATOM   3851 C CB  . GLU B 2 226 ? 176.055 199.415 189.384 1.00 67.50  ? 226 GLU C CB  1 
ATOM   3852 C CG  . GLU B 2 226 ? 176.771 198.805 188.200 1.00 67.50  ? 226 GLU C CG  1 
ATOM   3853 C CD  . GLU B 2 226 ? 177.828 199.719 187.623 1.00 67.50  ? 226 GLU C CD  1 
ATOM   3854 O OE1 . GLU B 2 226 ? 178.021 200.826 188.167 1.00 67.50  ? 226 GLU C OE1 1 
ATOM   3855 O OE2 . GLU B 2 226 ? 178.474 199.326 186.631 1.00 67.50  ? 226 GLU C OE2 1 
ATOM   3856 N N   . SER B 2 227 ? 173.620 196.732 189.149 1.00 58.97  ? 227 SER C N   1 
ATOM   3857 C CA  . SER B 2 227 ? 172.557 196.212 188.306 1.00 58.97  ? 227 SER C CA  1 
ATOM   3858 C C   . SER B 2 227 ? 171.835 195.109 189.068 1.00 58.97  ? 227 SER C C   1 
ATOM   3859 O O   . SER B 2 227 ? 172.097 194.872 190.251 1.00 58.97  ? 227 SER C O   1 
ATOM   3860 C CB  . SER B 2 227 ? 173.117 195.721 186.968 1.00 58.97  ? 227 SER C CB  1 
ATOM   3861 O OG  . SER B 2 227 ? 172.123 195.036 186.225 1.00 58.97  ? 227 SER C OG  1 
ATOM   3862 N N   . ASP B 2 228 ? 170.918 194.436 188.382 1.00 55.41  ? 228 ASP C N   1 
ATOM   3863 C CA  . ASP B 2 228 ? 170.116 193.395 189.006 1.00 55.41  ? 228 ASP C CA  1 
ATOM   3864 C C   . ASP B 2 228 ? 170.979 192.178 189.314 1.00 55.41  ? 228 ASP C C   1 
ATOM   3865 O O   . ASP B 2 228 ? 171.714 191.692 188.450 1.00 55.41  ? 228 ASP C O   1 
ATOM   3866 C CB  . ASP B 2 228 ? 168.959 193.013 188.084 1.00 55.41  ? 228 ASP C CB  1 
ATOM   3867 C CG  . ASP B 2 228 ? 167.913 192.159 188.772 1.00 55.41  ? 228 ASP C CG  1 
ATOM   3868 O OD1 . ASP B 2 228 ? 168.066 191.848 189.971 1.00 55.41  ? 228 ASP C OD1 1 
ATOM   3869 O OD2 . ASP B 2 228 ? 166.917 191.806 188.112 1.00 55.41  ? 228 ASP C OD2 1 
ATOM   3870 N N   . ILE B 2 229 ? 170.879 191.680 190.545 1.00 51.83  ? 229 ILE C N   1 
ATOM   3871 C CA  . ILE B 2 229 ? 171.594 190.483 190.975 1.00 51.83  ? 229 ILE C CA  1 
ATOM   3872 C C   . ILE B 2 229 ? 170.683 189.281 190.782 1.00 51.83  ? 229 ILE C C   1 
ATOM   3873 O O   . ILE B 2 229 ? 169.596 189.213 191.365 1.00 51.83  ? 229 ILE C O   1 
ATOM   3874 C CB  . ILE B 2 229 ? 172.058 190.599 192.437 1.00 51.83  ? 229 ILE C CB  1 
ATOM   3875 C CG1 . ILE B 2 229 ? 173.312 191.467 192.529 1.00 51.83  ? 229 ILE C CG1 1 
ATOM   3876 C CG2 . ILE B 2 229 ? 172.334 189.236 193.032 1.00 51.83  ? 229 ILE C CG2 1 
ATOM   3877 C CD1 . ILE B 2 229 ? 173.561 192.023 193.905 1.00 51.83  ? 229 ILE C CD1 1 
ATOM   3878 N N   . ASN B 2 230 ? 171.132 188.330 189.968 1.00 47.39  ? 230 ASN C N   1 
ATOM   3879 C CA  . ASN B 2 230 ? 170.345 187.143 189.668 1.00 47.39  ? 230 ASN C CA  1 
ATOM   3880 C C   . ASN B 2 230 ? 171.140 185.849 189.806 1.00 47.39  ? 230 ASN C C   1 
ATOM   3881 O O   . ASN B 2 230 ? 170.737 184.829 189.232 1.00 47.39  ? 230 ASN C O   1 
ATOM   3882 C CB  . ASN B 2 230 ? 169.750 187.257 188.264 1.00 47.39  ? 230 ASN C CB  1 
ATOM   3883 C CG  . ASN B 2 230 ? 170.790 187.586 187.226 1.00 47.39  ? 230 ASN C CG  1 
ATOM   3884 O OD1 . ASN B 2 230 ? 171.973 187.704 187.539 1.00 47.39  ? 230 ASN C OD1 1 
ATOM   3885 N ND2 . ASN B 2 230 ? 170.360 187.729 185.981 1.00 47.39  ? 230 ASN C ND2 1 
ATOM   3886 N N   . ALA B 2 231 ? 172.243 185.856 190.552 1.00 45.63  ? 231 ALA C N   1 
ATOM   3887 C CA  . ALA B 2 231 ? 173.058 184.665 190.751 1.00 45.63  ? 231 ALA C CA  1 
ATOM   3888 C C   . ALA B 2 231 ? 173.838 184.825 192.042 1.00 45.63  ? 231 ALA C C   1 
ATOM   3889 O O   . ALA B 2 231 ? 174.655 185.742 192.163 1.00 45.63  ? 231 ALA C O   1 
ATOM   3890 C CB  . ALA B 2 231 ? 174.008 184.450 189.578 1.00 45.63  ? 231 ALA C CB  1 
ATOM   3891 N N   . ILE B 2 232 ? 173.596 183.932 192.998 1.00 45.69  ? 232 ILE C N   1 
ATOM   3892 C CA  . ILE B 2 232 ? 174.281 183.959 194.282 1.00 45.69  ? 232 ILE C CA  1 
ATOM   3893 C C   . ILE B 2 232 ? 174.656 182.533 194.667 1.00 45.69  ? 232 ILE C C   1 
ATOM   3894 O O   . ILE B 2 232 ? 173.999 181.567 194.264 1.00 45.69  ? 232 ILE C O   1 
ATOM   3895 C CB  . ILE B 2 232 ? 173.418 184.646 195.373 1.00 45.69  ? 232 ILE C CB  1 
ATOM   3896 C CG1 . ILE B 2 232 ? 174.291 185.211 196.492 1.00 45.69  ? 232 ILE C CG1 1 
ATOM   3897 C CG2 . ILE B 2 232 ? 172.373 183.720 195.936 1.00 45.69  ? 232 ILE C CG2 1 
ATOM   3898 C CD1 . ILE B 2 232 ? 174.997 186.453 196.110 1.00 45.69  ? 232 ILE C CD1 1 
ATOM   3899 N N   . CYS B 2 233 ? 175.755 182.409 195.412 1.00 50.11  ? 233 CYS C N   1 
ATOM   3900 C CA  . CYS B 2 233 ? 176.213 181.138 195.960 1.00 50.11  ? 233 CYS C CA  1 
ATOM   3901 C C   . CYS B 2 233 ? 177.268 181.415 197.020 1.00 50.11  ? 233 CYS C C   1 
ATOM   3902 O O   . CYS B 2 233 ? 178.095 182.319 196.878 1.00 50.11  ? 233 CYS C O   1 
ATOM   3903 C CB  . CYS B 2 233 ? 176.788 180.213 194.885 1.00 50.11  ? 233 CYS C CB  1 
ATOM   3904 S SG  . CYS B 2 233 ? 178.283 180.832 194.109 1.00 50.11  ? 233 CYS C SG  1 
ATOM   3905 N N   . PHE B 2 234 ? 177.221 180.627 198.088 1.00 49.27  ? 234 PHE C N   1 
ATOM   3906 C CA  . PHE B 2 234 ? 178.256 180.654 199.110 1.00 49.27  ? 234 PHE C CA  1 
ATOM   3907 C C   . PHE B 2 234 ? 179.564 180.070 198.603 1.00 49.27  ? 234 PHE C C   1 
ATOM   3908 O O   . PHE B 2 234 ? 179.579 179.201 197.726 1.00 49.27  ? 234 PHE C O   1 
ATOM   3909 C CB  . PHE B 2 234 ? 177.818 179.881 200.353 1.00 49.27  ? 234 PHE C CB  1 
ATOM   3910 C CG  . PHE B 2 234 ? 176.945 180.659 201.277 1.00 49.27  ? 234 PHE C CG  1 
ATOM   3911 C CD1 . PHE B 2 234 ? 177.506 181.535 202.187 1.00 49.27  ? 234 PHE C CD1 1 
ATOM   3912 C CD2 . PHE B 2 234 ? 175.577 180.530 201.239 1.00 49.27  ? 234 PHE C CD2 1 
ATOM   3913 C CE1 . PHE B 2 234 ? 176.718 182.255 203.053 1.00 49.27  ? 234 PHE C CE1 1 
ATOM   3914 C CE2 . PHE B 2 234 ? 174.785 181.254 202.102 1.00 49.27  ? 234 PHE C CE2 1 
ATOM   3915 C CZ  . PHE B 2 234 ? 175.355 182.116 203.009 1.00 49.27  ? 234 PHE C CZ  1 
ATOM   3916 N N   . PHE B 2 235 ? 180.661 180.561 199.167 1.00 49.83  ? 235 PHE C N   1 
ATOM   3917 C CA  . PHE B 2 235 ? 181.924 179.860 199.081 1.00 49.83  ? 235 PHE C CA  1 
ATOM   3918 C C   . PHE B 2 235 ? 181.784 178.545 199.850 1.00 49.83  ? 235 PHE C C   1 
ATOM   3919 O O   . PHE B 2 235 ? 181.045 178.480 200.838 1.00 49.83  ? 235 PHE C O   1 
ATOM   3920 C CB  . PHE B 2 235 ? 183.030 180.716 199.692 1.00 49.83  ? 235 PHE C CB  1 
ATOM   3921 C CG  . PHE B 2 235 ? 184.408 180.384 199.219 1.00 49.83  ? 235 PHE C CG  1 
ATOM   3922 C CD1 . PHE B 2 235 ? 184.904 180.973 198.070 1.00 49.83  ? 235 PHE C CD1 1 
ATOM   3923 C CD2 . PHE B 2 235 ? 185.211 179.501 199.914 1.00 49.83  ? 235 PHE C CD2 1 
ATOM   3924 C CE1 . PHE B 2 235 ? 186.172 180.689 197.626 1.00 49.83  ? 235 PHE C CE1 1 
ATOM   3925 C CE2 . PHE B 2 235 ? 186.479 179.206 199.468 1.00 49.83  ? 235 PHE C CE2 1 
ATOM   3926 C CZ  . PHE B 2 235 ? 186.960 179.803 198.324 1.00 49.83  ? 235 PHE C CZ  1 
ATOM   3927 N N   . PRO B 2 236 ? 182.451 177.475 199.406 1.00 50.84  ? 236 PRO C N   1 
ATOM   3928 C CA  . PRO B 2 236 ? 182.302 176.182 200.099 1.00 50.84  ? 236 PRO C CA  1 
ATOM   3929 C C   . PRO B 2 236 ? 182.784 176.177 201.541 1.00 50.84  ? 236 PRO C C   1 
ATOM   3930 O O   . PRO B 2 236 ? 182.384 175.288 202.301 1.00 50.84  ? 236 PRO C O   1 
ATOM   3931 C CB  . PRO B 2 236 ? 183.127 175.220 199.231 1.00 50.84  ? 236 PRO C CB  1 
ATOM   3932 C CG  . PRO B 2 236 ? 183.945 176.093 198.337 1.00 50.84  ? 236 PRO C CG  1 
ATOM   3933 C CD  . PRO B 2 236 ? 183.118 177.307 198.108 1.00 50.84  ? 236 PRO C CD  1 
ATOM   3934 N N   . ASN B 2 237 ? 183.619 177.130 201.950 1.00 52.35  ? 237 ASN C N   1 
ATOM   3935 C CA  . ASN B 2 237 ? 184.020 177.209 203.348 1.00 52.35  ? 237 ASN C CA  1 
ATOM   3936 C C   . ASN B 2 237 ? 182.963 177.864 204.228 1.00 52.35  ? 237 ASN C C   1 
ATOM   3937 O O   . ASN B 2 237 ? 183.043 177.749 205.456 1.00 52.35  ? 237 ASN C O   1 
ATOM   3938 C CB  . ASN B 2 237 ? 185.368 177.943 203.478 1.00 52.35  ? 237 ASN C CB  1 
ATOM   3939 C CG  . ASN B 2 237 ? 185.230 179.458 203.557 1.00 52.35  ? 237 ASN C CG  1 
ATOM   3940 O OD1 . ASN B 2 237 ? 184.408 180.072 202.876 1.00 52.35  ? 237 ASN C OD1 1 
ATOM   3941 N ND2 . ASN B 2 237 ? 186.056 180.069 204.396 1.00 52.35  ? 237 ASN C ND2 1 
ATOM   3942 N N   . GLY B 2 238 ? 181.984 178.543 203.633 1.00 53.89  ? 238 GLY C N   1 
ATOM   3943 C CA  . GLY B 2 238 ? 180.894 179.140 204.370 1.00 53.89  ? 238 GLY C CA  1 
ATOM   3944 C C   . GLY B 2 238 ? 181.146 180.539 204.887 1.00 53.89  ? 238 GLY C C   1 
ATOM   3945 O O   . GLY B 2 238 ? 180.212 181.165 205.404 1.00 53.89  ? 238 GLY C O   1 
ATOM   3946 N N   . ASN B 2 239 ? 182.367 181.055 204.768 1.00 58.26  ? 239 ASN C N   1 
ATOM   3947 C CA  . ASN B 2 239 ? 182.695 182.391 205.244 1.00 58.26  ? 239 ASN C CA  1 
ATOM   3948 C C   . ASN B 2 239 ? 182.803 183.407 204.118 1.00 58.26  ? 239 ASN C C   1 
ATOM   3949 O O   . ASN B 2 239 ? 183.310 184.510 204.340 1.00 58.26  ? 239 ASN C O   1 
ATOM   3950 C CB  . ASN B 2 239 ? 183.994 182.365 206.051 1.00 58.26  ? 239 ASN C CB  1 
ATOM   3951 C CG  . ASN B 2 239 ? 183.906 181.463 207.265 1.00 58.26  ? 239 ASN C CG  1 
ATOM   3952 O OD1 . ASN B 2 239 ? 182.817 181.175 207.762 1.00 58.26  ? 239 ASN C OD1 1 
ATOM   3953 N ND2 . ASN B 2 239 ? 185.056 181.013 207.753 1.00 58.26  ? 239 ASN C ND2 1 
ATOM   3954 N N   . ALA B 2 240 ? 182.346 183.061 202.918 1.00 55.47  ? 240 ALA C N   1 
ATOM   3955 C CA  . ALA B 2 240 ? 182.332 183.989 201.800 1.00 55.47  ? 240 ALA C CA  1 
ATOM   3956 C C   . ALA B 2 240 ? 181.219 183.577 200.850 1.00 55.47  ? 240 ALA C C   1 
ATOM   3957 O O   . ALA B 2 240 ? 180.663 182.482 200.952 1.00 55.47  ? 240 ALA C O   1 
ATOM   3958 C CB  . ALA B 2 240 ? 183.685 184.038 201.085 1.00 55.47  ? 240 ALA C CB  1 
ATOM   3959 N N   . PHE B 2 241 ? 180.876 184.482 199.936 1.00 55.64  ? 241 PHE C N   1 
ATOM   3960 C CA  . PHE B 2 241 ? 179.884 184.179 198.914 1.00 55.64  ? 241 PHE C CA  1 
ATOM   3961 C C   . PHE B 2 241 ? 180.111 185.089 197.715 1.00 55.64  ? 241 PHE C C   1 
ATOM   3962 O O   . PHE B 2 241 ? 180.391 186.279 197.877 1.00 55.64  ? 241 PHE C O   1 
ATOM   3963 C CB  . PHE B 2 241 ? 178.453 184.316 199.460 1.00 55.64  ? 241 PHE C CB  1 
ATOM   3964 C CG  . PHE B 2 241 ? 178.039 185.724 199.781 1.00 55.64  ? 241 PHE C CG  1 
ATOM   3965 C CD1 . PHE B 2 241 ? 178.423 186.321 200.968 1.00 55.64  ? 241 PHE C CD1 1 
ATOM   3966 C CD2 . PHE B 2 241 ? 177.217 186.426 198.921 1.00 55.64  ? 241 PHE C CD2 1 
ATOM   3967 C CE1 . PHE B 2 241 ? 178.028 187.607 201.268 1.00 55.64  ? 241 PHE C CE1 1 
ATOM   3968 C CE2 . PHE B 2 241 ? 176.821 187.706 199.214 1.00 55.64  ? 241 PHE C CE2 1 
ATOM   3969 C CZ  . PHE B 2 241 ? 177.224 188.299 200.390 1.00 55.64  ? 241 PHE C CZ  1 
ATOM   3970 N N   . ALA B 2 242 ? 180.011 184.518 196.519 1.00 49.76  ? 242 ALA C N   1 
ATOM   3971 C CA  . ALA B 2 242 ? 180.214 185.258 195.283 1.00 49.76  ? 242 ALA C CA  1 
ATOM   3972 C C   . ALA B 2 242 ? 178.878 185.588 194.638 1.00 49.76  ? 242 ALA C C   1 
ATOM   3973 O O   . ALA B 2 242 ? 177.927 184.806 194.700 1.00 49.76  ? 242 ALA C O   1 
ATOM   3974 C CB  . ALA B 2 242 ? 181.076 184.474 194.298 1.00 49.76  ? 242 ALA C CB  1 
ATOM   3975 N N   . THR B 2 243 ? 178.825 186.752 193.999 1.00 54.81  ? 243 THR C N   1 
ATOM   3976 C CA  . THR B 2 243 ? 177.589 187.321 193.484 1.00 54.81  ? 243 THR C CA  1 
ATOM   3977 C C   . THR B 2 243 ? 177.677 187.483 191.975 1.00 54.81  ? 243 THR C C   1 
ATOM   3978 O O   . THR B 2 243 ? 178.617 188.102 191.467 1.00 54.81  ? 243 THR C O   1 
ATOM   3979 C CB  . THR B 2 243 ? 177.310 188.678 194.131 1.00 54.81  ? 243 THR C CB  1 
ATOM   3980 O OG1 . THR B 2 243 ? 177.410 188.559 195.554 1.00 54.81  ? 243 THR C OG1 1 
ATOM   3981 C CG2 . THR B 2 243 ? 175.930 189.159 193.769 1.00 54.81  ? 243 THR C CG2 1 
ATOM   3982 N N   . GLY B 2 244 ? 176.697 186.936 191.268 1.00 50.31  ? 244 GLY C N   1 
ATOM   3983 C CA  . GLY B 2 244 ? 176.573 187.110 189.829 1.00 50.31  ? 244 GLY C CA  1 
ATOM   3984 C C   . GLY B 2 244 ? 175.366 187.977 189.522 1.00 50.31  ? 244 GLY C C   1 
ATOM   3985 O O   . GLY B 2 244 ? 174.260 187.706 189.996 1.00 50.31  ? 244 GLY C O   1 
ATOM   3986 N N   . SER B 2 245 ? 175.584 189.014 188.721 1.00 55.21  ? 245 SER C N   1 
ATOM   3987 C CA  . SER B 2 245 ? 174.557 190.007 188.461 1.00 55.21  ? 245 SER C CA  1 
ATOM   3988 C C   . SER B 2 245 ? 174.387 190.178 186.961 1.00 55.21  ? 245 SER C C   1 
ATOM   3989 O O   . SER B 2 245 ? 175.079 189.551 186.156 1.00 55.21  ? 245 SER C O   1 
ATOM   3990 C CB  . SER B 2 245 ? 174.906 191.350 189.102 1.00 55.21  ? 245 SER C CB  1 
ATOM   3991 O OG  . SER B 2 245 ? 176.059 191.898 188.494 1.00 55.21  ? 245 SER C OG  1 
ATOM   3992 N N   . ASP B 2 246 ? 173.446 191.042 186.593 1.00 56.28  ? 246 ASP C N   1 
ATOM   3993 C CA  . ASP B 2 246 ? 173.223 191.405 185.195 1.00 56.28  ? 246 ASP C CA  1 
ATOM   3994 C C   . ASP B 2 246 ? 174.019 192.666 184.847 1.00 56.28  ? 246 ASP C C   1 
ATOM   3995 O O   . ASP B 2 246 ? 173.492 193.665 184.362 1.00 56.28  ? 246 ASP C O   1 
ATOM   3996 C CB  . ASP B 2 246 ? 171.734 191.594 184.938 1.00 56.28  ? 246 ASP C CB  1 
ATOM   3997 C CG  . ASP B 2 246 ? 171.383 191.544 183.468 1.00 56.28  ? 246 ASP C CG  1 
ATOM   3998 O OD1 . ASP B 2 246 ? 172.297 191.357 182.640 1.00 56.28  ? 246 ASP C OD1 1 
ATOM   3999 O OD2 . ASP B 2 246 ? 170.189 191.700 183.136 1.00 56.28  ? 246 ASP C OD2 1 
ATOM   4000 N N   . ASP B 2 247 ? 175.326 192.594 185.106 1.00 59.98  ? 247 ASP C N   1 
ATOM   4001 C CA  . ASP B 2 247 ? 176.198 193.752 184.964 1.00 59.98  ? 247 ASP C CA  1 
ATOM   4002 C C   . ASP B 2 247 ? 177.490 193.402 184.230 1.00 59.98  ? 247 ASP C C   1 
ATOM   4003 O O   . ASP B 2 247 ? 178.378 194.260 184.126 1.00 59.98  ? 247 ASP C O   1 
ATOM   4004 C CB  . ASP B 2 247 ? 176.504 194.333 186.357 1.00 59.98  ? 247 ASP C CB  1 
ATOM   4005 C CG  . ASP B 2 247 ? 177.098 195.727 186.305 1.00 59.98  ? 247 ASP C CG  1 
ATOM   4006 O OD1 . ASP B 2 247 ? 176.712 196.506 185.410 1.00 59.98  ? 247 ASP C OD1 1 
ATOM   4007 O OD2 . ASP B 2 247 ? 177.977 196.023 187.138 1.00 59.98  ? 247 ASP C OD2 1 
ATOM   4008 N N   . ALA B 2 248 ? 177.604 192.178 183.700 1.00 65.14  ? 248 ALA C N   1 
ATOM   4009 C CA  . ALA B 2 248 ? 178.838 191.642 183.109 1.00 65.14  ? 248 ALA C CA  1 
ATOM   4010 C C   . ALA B 2 248 ? 180.001 191.690 184.097 1.00 65.14  ? 248 ALA C C   1 
ATOM   4011 O O   . ALA B 2 248 ? 181.133 192.016 183.738 1.00 65.14  ? 248 ALA C O   1 
ATOM   4012 C CB  . ALA B 2 248 ? 179.204 192.348 181.799 1.00 65.14  ? 248 ALA C CB  1 
ATOM   4013 N N   . THR B 2 249 ? 179.715 191.362 185.356 1.00 66.21  ? 249 THR C N   1 
ATOM   4014 C CA  . THR B 2 249 ? 180.744 191.250 186.376 1.00 66.21  ? 249 THR C CA  1 
ATOM   4015 C C   . THR B 2 249 ? 180.280 190.275 187.448 1.00 66.21  ? 249 THR C C   1 
ATOM   4016 O O   . THR B 2 249 ? 179.079 190.074 187.652 1.00 66.21  ? 249 THR C O   1 
ATOM   4017 C CB  . THR B 2 249 ? 181.083 192.608 187.007 1.00 66.21  ? 249 THR C CB  1 
ATOM   4018 O OG1 . THR B 2 249 ? 182.076 192.430 188.024 1.00 66.21  ? 249 THR C OG1 1 
ATOM   4019 C CG2 . THR B 2 249 ? 179.846 193.246 187.620 1.00 66.21  ? 249 THR C CG2 1 
ATOM   4020 N N   . CYS B 2 250 ? 181.250 189.659 188.117 1.00 64.37  ? 250 CYS C N   1 
ATOM   4021 C CA  . CYS B 2 250 ? 181.009 188.801 189.267 1.00 64.37  ? 250 CYS C CA  1 
ATOM   4022 C C   . CYS B 2 250 ? 181.813 189.349 190.435 1.00 64.37  ? 250 CYS C C   1 
ATOM   4023 O O   . CYS B 2 250 ? 182.972 189.736 190.262 1.00 64.37  ? 250 CYS C O   1 
ATOM   4024 C CB  . CYS B 2 250 ? 181.402 187.352 188.975 1.00 64.37  ? 250 CYS C CB  1 
ATOM   4025 S SG  . CYS B 2 250 ? 180.233 186.458 187.938 1.00 64.37  ? 250 CYS C SG  1 
ATOM   4026 N N   . ARG B 2 251 ? 181.196 189.409 191.609 1.00 67.33  ? 251 ARG C N   1 
ATOM   4027 C CA  . ARG B 2 251 ? 181.819 190.008 192.780 1.00 67.33  ? 251 ARG C CA  1 
ATOM   4028 C C   . ARG B 2 251 ? 181.792 189.029 193.942 1.00 67.33  ? 251 ARG C C   1 
ATOM   4029 O O   . ARG B 2 251 ? 180.838 188.261 194.098 1.00 67.33  ? 251 ARG C O   1 
ATOM   4030 C CB  . ARG B 2 251 ? 181.119 191.314 193.165 1.00 67.33  ? 251 ARG C CB  1 
ATOM   4031 C CG  . ARG B 2 251 ? 181.181 192.368 192.074 1.00 67.33  ? 251 ARG C CG  1 
ATOM   4032 C CD  . ARG B 2 251 ? 180.699 193.725 192.547 1.00 67.33  ? 251 ARG C CD  1 
ATOM   4033 N NE  . ARG B 2 251 ? 180.940 194.753 191.541 1.00 67.33  ? 251 ARG C NE  1 
ATOM   4034 C CZ  . ARG B 2 251 ? 181.602 195.881 191.763 1.00 67.33  ? 251 ARG C CZ  1 
ATOM   4035 N NH1 . ARG B 2 251 ? 182.095 196.170 192.955 1.00 67.33  ? 251 ARG C NH1 1 
ATOM   4036 N NH2 . ARG B 2 251 ? 181.773 196.740 190.763 1.00 67.33  ? 251 ARG C NH2 1 
ATOM   4037 N N   . LEU B 2 252 ? 182.846 189.062 194.752 1.00 65.93  ? 252 LEU C N   1 
ATOM   4038 C CA  . LEU B 2 252 ? 183.009 188.171 195.892 1.00 65.93  ? 252 LEU C CA  1 
ATOM   4039 C C   . LEU B 2 252 ? 182.916 188.959 197.192 1.00 65.93  ? 252 LEU C C   1 
ATOM   4040 O O   . LEU B 2 252 ? 183.621 189.957 197.371 1.00 65.93  ? 252 LEU C O   1 
ATOM   4041 C CB  . LEU B 2 252 ? 184.347 187.439 195.817 1.00 65.93  ? 252 LEU C CB  1 
ATOM   4042 C CG  . LEU B 2 252 ? 184.614 186.445 196.943 1.00 65.93  ? 252 LEU C CG  1 
ATOM   4043 C CD1 . LEU B 2 252 ? 183.786 185.192 196.754 1.00 65.93  ? 252 LEU C CD1 1 
ATOM   4044 C CD2 . LEU B 2 252 ? 186.093 186.110 196.999 1.00 65.93  ? 252 LEU C CD2 1 
ATOM   4045 N N   . PHE B 2 253 ? 182.052 188.505 198.094 1.00 63.72  ? 253 PHE C N   1 
ATOM   4046 C CA  . PHE B 2 253 ? 181.876 189.113 199.403 1.00 63.72  ? 253 PHE C CA  1 
ATOM   4047 C C   . PHE B 2 253 ? 182.131 188.068 200.478 1.00 63.72  ? 253 PHE C C   1 
ATOM   4048 O O   . PHE B 2 253 ? 181.960 186.868 200.246 1.00 63.72  ? 253 PHE C O   1 
ATOM   4049 C CB  . PHE B 2 253 ? 180.466 189.678 199.576 1.00 63.72  ? 253 PHE C CB  1 
ATOM   4050 C CG  . PHE B 2 253 ? 180.024 190.565 198.454 1.00 63.72  ? 253 PHE C CG  1 
ATOM   4051 C CD1 . PHE B 2 253 ? 180.851 191.565 197.976 1.00 63.72  ? 253 PHE C CD1 1 
ATOM   4052 C CD2 . PHE B 2 253 ? 178.773 190.406 197.884 1.00 63.72  ? 253 PHE C CD2 1 
ATOM   4053 C CE1 . PHE B 2 253 ? 180.443 192.381 196.945 1.00 63.72  ? 253 PHE C CE1 1 
ATOM   4054 C CE2 . PHE B 2 253 ? 178.360 191.225 196.854 1.00 63.72  ? 253 PHE C CE2 1 
ATOM   4055 C CZ  . PHE B 2 253 ? 179.196 192.211 196.383 1.00 63.72  ? 253 PHE C CZ  1 
ATOM   4056 N N   . ASP B 2 254 ? 182.535 188.524 201.659 1.00 67.64  ? 254 ASP C N   1 
ATOM   4057 C CA  . ASP B 2 254 ? 182.752 187.624 202.780 1.00 67.64  ? 254 ASP C CA  1 
ATOM   4058 C C   . ASP B 2 254 ? 181.694 187.842 203.852 1.00 67.64  ? 254 ASP C C   1 
ATOM   4059 O O   . ASP B 2 254 ? 181.072 188.901 203.941 1.00 67.64  ? 254 ASP C O   1 
ATOM   4060 C CB  . ASP B 2 254 ? 184.152 187.800 203.379 1.00 67.64  ? 254 ASP C CB  1 
ATOM   4061 C CG  . ASP B 2 254 ? 184.384 189.186 203.926 1.00 67.64  ? 254 ASP C CG  1 
ATOM   4062 O OD1 . ASP B 2 254 ? 183.687 190.129 203.498 1.00 67.64  ? 254 ASP C OD1 1 
ATOM   4063 O OD2 . ASP B 2 254 ? 185.271 189.331 204.791 1.00 67.64  ? 254 ASP C OD2 1 
ATOM   4064 N N   . LEU B 2 255 ? 181.495 186.815 204.670 1.00 63.36  ? 255 LEU C N   1 
ATOM   4065 C CA  . LEU B 2 255 ? 180.509 186.879 205.736 1.00 63.36  ? 255 LEU C CA  1 
ATOM   4066 C C   . LEU B 2 255 ? 181.031 187.589 206.973 1.00 63.36  ? 255 LEU C C   1 
ATOM   4067 O O   . LEU B 2 255 ? 180.249 187.859 207.890 1.00 63.36  ? 255 LEU C O   1 
ATOM   4068 C CB  . LEU B 2 255 ? 180.051 185.471 206.132 1.00 63.36  ? 255 LEU C CB  1 
ATOM   4069 C CG  . LEU B 2 255 ? 178.956 184.765 205.325 1.00 63.36  ? 255 LEU C CG  1 
ATOM   4070 C CD1 . LEU B 2 255 ? 177.674 185.562 205.389 1.00 63.36  ? 255 LEU C CD1 1 
ATOM   4071 C CD2 . LEU B 2 255 ? 179.347 184.478 203.889 1.00 63.36  ? 255 LEU C CD2 1 
ATOM   4072 N N   . ARG B 2 256 ? 182.324 187.895 207.019 1.00 68.86  ? 256 ARG C N   1 
ATOM   4073 C CA  . ARG B 2 256 ? 182.969 188.400 208.223 1.00 68.86  ? 256 ARG C CA  1 
ATOM   4074 C C   . ARG B 2 256 ? 183.236 189.898 208.172 1.00 68.86  ? 256 ARG C C   1 
ATOM   4075 O O   . ARG B 2 256 ? 183.201 190.564 209.211 1.00 68.86  ? 256 ARG C O   1 
ATOM   4076 C CB  . ARG B 2 256 ? 184.271 187.626 208.456 1.00 68.86  ? 256 ARG C CB  1 
ATOM   4077 C CG  . ARG B 2 256 ? 185.004 187.943 209.740 1.00 68.86  ? 256 ARG C CG  1 
ATOM   4078 C CD  . ARG B 2 256 ? 186.162 186.983 209.937 1.00 68.86  ? 256 ARG C CD  1 
ATOM   4079 N NE  . ARG B 2 256 ? 185.696 185.625 210.190 1.00 68.86  ? 256 ARG C NE  1 
ATOM   4080 C CZ  . ARG B 2 256 ? 185.872 184.601 209.367 1.00 68.86  ? 256 ARG C CZ  1 
ATOM   4081 N NH1 . ARG B 2 256 ? 186.507 184.741 208.215 1.00 68.86  ? 256 ARG C NH1 1 
ATOM   4082 N NH2 . ARG B 2 256 ? 185.395 183.407 209.706 1.00 68.86  ? 256 ARG C NH2 1 
ATOM   4083 N N   . ALA B 2 257 ? 183.482 190.451 206.986 1.00 75.07  ? 257 ALA C N   1 
ATOM   4084 C CA  . ALA B 2 257 ? 183.617 191.893 206.819 1.00 75.07  ? 257 ALA C CA  1 
ATOM   4085 C C   . ALA B 2 257 ? 182.561 192.506 205.913 1.00 75.07  ? 257 ALA C C   1 
ATOM   4086 O O   . ALA B 2 257 ? 182.247 193.687 206.076 1.00 75.07  ? 257 ALA C O   1 
ATOM   4087 C CB  . ALA B 2 257 ? 185.005 192.240 206.268 1.00 75.07  ? 257 ALA C CB  1 
ATOM   4088 N N   . ASP B 2 258 ? 182.015 191.725 204.975 1.00 77.18  ? 258 ASP C N   1 
ATOM   4089 C CA  . ASP B 2 258 ? 180.996 192.154 204.010 1.00 77.18  ? 258 ASP C CA  1 
ATOM   4090 C C   . ASP B 2 258 ? 181.486 193.338 203.172 1.00 77.18  ? 258 ASP C C   1 
ATOM   4091 O O   . ASP B 2 258 ? 180.909 194.426 203.179 1.00 77.18  ? 258 ASP C O   1 
ATOM   4092 C CB  . ASP B 2 258 ? 179.666 192.477 204.707 1.00 77.18  ? 258 ASP C CB  1 
ATOM   4093 C CG  . ASP B 2 258 ? 178.463 192.048 203.887 1.00 77.18  ? 258 ASP C CG  1 
ATOM   4094 O OD1 . ASP B 2 258 ? 178.650 191.511 202.777 1.00 77.18  ? 258 ASP C OD1 1 
ATOM   4095 O OD2 . ASP B 2 258 ? 177.324 192.252 204.352 1.00 77.18  ? 258 ASP C OD2 1 
ATOM   4096 N N   . GLN B 2 259 ? 182.576 193.102 202.448 1.00 82.55  ? 259 GLN C N   1 
ATOM   4097 C CA  . GLN B 2 259 ? 183.192 194.104 201.595 1.00 82.55  ? 259 GLN C CA  1 
ATOM   4098 C C   . GLN B 2 259 ? 183.493 193.511 200.227 1.00 82.55  ? 259 GLN C C   1 
ATOM   4099 O O   . GLN B 2 259 ? 183.289 192.322 199.976 1.00 82.55  ? 259 GLN C O   1 
ATOM   4100 C CB  . GLN B 2 259 ? 184.477 194.661 202.219 1.00 82.55  ? 259 GLN C CB  1 
ATOM   4101 C CG  . GLN B 2 259 ? 184.269 195.349 203.549 1.00 82.55  ? 259 GLN C CG  1 
ATOM   4102 C CD  . GLN B 2 259 ? 185.569 195.646 204.249 1.00 82.55  ? 259 GLN C CD  1 
ATOM   4103 O OE1 . GLN B 2 259 ? 186.566 195.971 203.609 1.00 82.55  ? 259 GLN C OE1 1 
ATOM   4104 N NE2 . GLN B 2 259 ? 185.566 195.550 205.573 1.00 82.55  ? 259 GLN C NE2 1 
ATOM   4105 N N   . GLU B 2 260 ? 183.991 194.369 199.338 1.00 78.01  ? 260 GLU C N   1 
ATOM   4106 C CA  . GLU B 2 260 ? 184.366 193.952 197.989 1.00 78.01  ? 260 GLU C CA  1 
ATOM   4107 C C   . GLU B 2 260 ? 185.733 193.280 197.989 1.00 78.01  ? 260 GLU C C   1 
ATOM   4108 O O   . GLU B 2 260 ? 186.764 193.958 197.933 1.00 78.01  ? 260 GLU C O   1 
ATOM   4109 C CB  . GLU B 2 260 ? 184.365 195.152 197.042 1.00 78.01  ? 260 GLU C CB  1 
ATOM   4110 C CG  . GLU B 2 260 ? 184.645 194.797 195.591 1.00 78.01  ? 260 GLU C CG  1 
ATOM   4111 C CD  . GLU B 2 260 ? 183.493 194.065 194.942 1.00 78.01  ? 260 GLU C CD  1 
ATOM   4112 O OE1 . GLU B 2 260 ? 182.338 194.313 195.340 1.00 78.01  ? 260 GLU C OE1 1 
ATOM   4113 O OE2 . GLU B 2 260 ? 183.741 193.242 194.036 1.00 78.01  ? 260 GLU C OE2 1 
ATOM   4114 N N   . LEU B 2 261 ? 185.749 191.950 198.070 1.00 74.35  ? 261 LEU C N   1 
ATOM   4115 C CA  . LEU B 2 261 ? 187.014 191.224 198.039 1.00 74.35  ? 261 LEU C CA  1 
ATOM   4116 C C   . LEU B 2 261 ? 187.626 191.238 196.644 1.00 74.35  ? 261 LEU C C   1 
ATOM   4117 O O   . LEU B 2 261 ? 188.808 191.559 196.477 1.00 74.35  ? 261 LEU C O   1 
ATOM   4118 C CB  . LEU B 2 261 ? 186.816 189.784 198.517 1.00 74.35  ? 261 LEU C CB  1 
ATOM   4119 C CG  . LEU B 2 261 ? 186.857 189.462 200.015 1.00 74.35  ? 261 LEU C CG  1 
ATOM   4120 C CD1 . LEU B 2 261 ? 188.223 189.808 200.586 1.00 74.35  ? 261 LEU C CD1 1 
ATOM   4121 C CD2 . LEU B 2 261 ? 185.745 190.135 200.811 1.00 74.35  ? 261 LEU C CD2 1 
ATOM   4122 N N   . MET B 2 262 ? 186.832 190.904 195.630 1.00 72.69  ? 262 MET C N   1 
ATOM   4123 C CA  . MET B 2 262 ? 187.353 190.737 194.283 1.00 72.69  ? 262 MET C CA  1 
ATOM   4124 C C   . MET B 2 262 ? 186.213 190.842 193.284 1.00 72.69  ? 262 MET C C   1 
ATOM   4125 O O   . MET B 2 262 ? 185.126 190.306 193.515 1.00 72.69  ? 262 MET C O   1 
ATOM   4126 C CB  . MET B 2 262 ? 188.066 189.387 194.132 1.00 72.69  ? 262 MET C CB  1 
ATOM   4127 C CG  . MET B 2 262 ? 188.723 189.182 192.782 1.00 72.69  ? 262 MET C CG  1 
ATOM   4128 S SD  . MET B 2 262 ? 190.013 190.388 192.448 1.00 72.69  ? 262 MET C SD  1 
ATOM   4129 C CE  . MET B 2 262 ? 191.309 189.755 193.497 1.00 72.69  ? 262 MET C CE  1 
ATOM   4130 N N   . THR B 2 263 ? 186.473 191.530 192.176 1.00 71.84  ? 263 THR C N   1 
ATOM   4131 C CA  . THR B 2 263 ? 185.540 191.625 191.066 1.00 71.84  ? 263 THR C CA  1 
ATOM   4132 C C   . THR B 2 263 ? 186.054 190.812 189.883 1.00 71.84  ? 263 THR C C   1 
ATOM   4133 O O   . THR B 2 263 ? 187.261 190.727 189.638 1.00 71.84  ? 263 THR C O   1 
ATOM   4134 C CB  . THR B 2 263 ? 185.309 193.087 190.658 1.00 71.84  ? 263 THR C CB  1 
ATOM   4135 O OG1 . THR B 2 263 ? 184.418 193.141 189.535 1.00 71.84  ? 263 THR C OG1 1 
ATOM   4136 C CG2 . THR B 2 263 ? 186.621 193.791 190.319 1.00 71.84  ? 263 THR C CG2 1 
ATOM   4137 N N   . TYR B 2 264 ? 185.122 190.188 189.164 1.00 68.98  ? 264 TYR C N   1 
ATOM   4138 C CA  . TYR B 2 264 ? 185.437 189.343 188.011 1.00 68.98  ? 264 TYR C CA  1 
ATOM   4139 C C   . TYR B 2 264 ? 184.745 189.950 186.797 1.00 68.98  ? 264 TYR C C   1 
ATOM   4140 O O   . TYR B 2 264 ? 183.624 189.568 186.453 1.00 68.98  ? 264 TYR C O   1 
ATOM   4141 C CB  . TYR B 2 264 ? 185.008 187.897 188.248 1.00 68.98  ? 264 TYR C CB  1 
ATOM   4142 C CG  . TYR B 2 264 ? 185.490 187.326 189.561 1.00 68.98  ? 264 TYR C CG  1 
ATOM   4143 C CD1 . TYR B 2 264 ? 186.828 187.032 189.759 1.00 68.98  ? 264 TYR C CD1 1 
ATOM   4144 C CD2 . TYR B 2 264 ? 184.606 187.087 190.603 1.00 68.98  ? 264 TYR C CD2 1 
ATOM   4145 C CE1 . TYR B 2 264 ? 187.272 186.515 190.955 1.00 68.98  ? 264 TYR C CE1 1 
ATOM   4146 C CE2 . TYR B 2 264 ? 185.042 186.577 191.805 1.00 68.98  ? 264 TYR C CE2 1 
ATOM   4147 C CZ  . TYR B 2 264 ? 186.375 186.290 191.975 1.00 68.98  ? 264 TYR C CZ  1 
ATOM   4148 O OH  . TYR B 2 264 ? 186.807 185.777 193.174 1.00 68.98  ? 264 TYR C OH  1 
ATOM   4149 N N   . SER B 2 265 ? 185.420 190.895 186.150 1.00 72.89  ? 265 SER C N   1 
ATOM   4150 C CA  . SER B 2 265 ? 184.888 191.562 184.974 1.00 72.89  ? 265 SER C CA  1 
ATOM   4151 C C   . SER B 2 265 ? 185.967 191.628 183.905 1.00 72.89  ? 265 SER C C   1 
ATOM   4152 O O   . SER B 2 265 ? 187.148 191.819 184.205 1.00 72.89  ? 265 SER C O   1 
ATOM   4153 C CB  . SER B 2 265 ? 184.387 192.973 185.304 1.00 72.89  ? 265 SER C CB  1 
ATOM   4154 O OG  . SER B 2 265 ? 185.426 193.763 185.856 1.00 72.89  ? 265 SER C OG  1 
ATOM   4155 N N   . HIS B 2 266 ? 185.547 191.477 182.653 1.00 77.38  ? 266 HIS C N   1 
ATOM   4156 C CA  . HIS B 2 266 ? 186.454 191.498 181.517 1.00 77.38  ? 266 HIS C CA  1 
ATOM   4157 C C   . HIS B 2 266 ? 185.868 192.373 180.418 1.00 77.38  ? 266 HIS C C   1 
ATOM   4158 O O   . HIS B 2 266 ? 184.651 192.561 180.333 1.00 77.38  ? 266 HIS C O   1 
ATOM   4159 C CB  . HIS B 2 266 ? 186.720 190.080 180.988 1.00 77.38  ? 266 HIS C CB  1 
ATOM   4160 C CG  . HIS B 2 266 ? 187.838 190.004 179.996 1.00 77.38  ? 266 HIS C CG  1 
ATOM   4161 N ND1 . HIS B 2 266 ? 187.624 189.790 178.651 1.00 77.38  ? 266 HIS C ND1 1 
ATOM   4162 C CD2 . HIS B 2 266 ? 189.178 190.118 180.151 1.00 77.38  ? 266 HIS C CD2 1 
ATOM   4163 C CE1 . HIS B 2 266 ? 188.785 189.773 178.021 1.00 77.38  ? 266 HIS C CE1 1 
ATOM   4164 N NE2 . HIS B 2 266 ? 189.744 189.970 178.908 1.00 77.38  ? 266 HIS C NE2 1 
ATOM   4165 N N   . ASP B 2 267 ? 186.755 192.916 179.582 1.00 80.69  ? 267 ASP C N   1 
ATOM   4166 C CA  . ASP B 2 267 ? 186.333 193.859 178.551 1.00 80.69  ? 267 ASP C CA  1 
ATOM   4167 C C   . ASP B 2 267 ? 185.546 193.167 177.443 1.00 80.69  ? 267 ASP C C   1 
ATOM   4168 O O   . ASP B 2 267 ? 184.587 193.736 176.909 1.00 80.69  ? 267 ASP C O   1 
ATOM   4169 C CB  . ASP B 2 267 ? 187.553 194.573 177.972 1.00 80.69  ? 267 ASP C CB  1 
ATOM   4170 C CG  . ASP B 2 267 ? 188.330 195.341 179.023 1.00 80.69  ? 267 ASP C CG  1 
ATOM   4171 O OD1 . ASP B 2 267 ? 187.843 195.444 180.168 1.00 80.69  ? 267 ASP C OD1 1 
ATOM   4172 O OD2 . ASP B 2 267 ? 189.430 195.839 178.704 1.00 80.69  ? 267 ASP C OD2 1 
ATOM   4173 N N   . ASN B 2 268 ? 185.931 191.940 177.088 1.00 75.21  ? 268 ASN C N   1 
ATOM   4174 C CA  . ASN B 2 268 ? 185.319 191.246 175.961 1.00 75.21  ? 268 ASN C CA  1 
ATOM   4175 C C   . ASN B 2 268 ? 183.906 190.756 176.250 1.00 75.21  ? 268 ASN C C   1 
ATOM   4176 O O   . ASN B 2 268 ? 183.212 190.346 175.314 1.00 75.21  ? 268 ASN C O   1 
ATOM   4177 C CB  . ASN B 2 268 ? 186.192 190.065 175.537 1.00 75.21  ? 268 ASN C CB  1 
ATOM   4178 N N   . ILE B 2 269 ? 183.467 190.780 177.504 1.00 69.46  ? 269 ILE C N   1 
ATOM   4179 C CA  . ILE B 2 269 ? 182.134 190.334 177.889 1.00 69.46  ? 269 ILE C CA  1 
ATOM   4180 C C   . ILE B 2 269 ? 181.334 191.538 178.371 1.00 69.46  ? 269 ILE C C   1 
ATOM   4181 O O   . ILE B 2 269 ? 181.786 192.291 179.243 1.00 69.46  ? 269 ILE C O   1 
ATOM   4182 C CB  . ILE B 2 269 ? 182.203 189.224 178.953 1.00 69.46  ? 269 ILE C CB  1 
ATOM   4183 C CG1 . ILE B 2 269 ? 183.236 189.572 180.026 1.00 69.46  ? 269 ILE C CG1 1 
ATOM   4184 C CG2 . ILE B 2 269 ? 182.530 187.888 178.307 1.00 69.46  ? 269 ILE C CG2 1 
ATOM   4185 C CD1 . ILE B 2 269 ? 183.277 188.612 181.177 1.00 69.46  ? 269 ILE C CD1 1 
ATOM   4186 N N   . ILE B 2 270 ? 180.160 191.738 177.775 1.00 68.03  ? 270 ILE C N   1 
ATOM   4187 C CA  . ILE B 2 270 ? 179.279 192.843 178.133 1.00 68.03  ? 270 ILE C CA  1 
ATOM   4188 C C   . ILE B 2 270 ? 177.898 192.286 178.438 1.00 68.03  ? 270 ILE C C   1 
ATOM   4189 O O   . ILE B 2 270 ? 176.958 193.036 178.724 1.00 68.03  ? 270 ILE C O   1 
ATOM   4190 C CB  . ILE B 2 270 ? 179.212 193.895 177.012 1.00 68.03  ? 270 ILE C CB  1 
ATOM   4191 C CG1 . ILE B 2 270 ? 178.749 193.244 175.708 1.00 68.03  ? 270 ILE C CG1 1 
ATOM   4192 C CG2 . ILE B 2 270 ? 180.556 194.585 176.838 1.00 68.03  ? 270 ILE C CG2 1 
ATOM   4193 C CD1 . ILE B 2 270 ? 178.447 194.232 174.604 1.00 68.03  ? 270 ILE C CD1 1 
ATOM   4194 N N   . CYS B 2 271 ? 177.771 190.967 178.387 1.00 53.83  ? 271 CYS C N   1 
ATOM   4195 C CA  . CYS B 2 271 ? 176.511 190.283 178.613 1.00 53.83  ? 271 CYS C CA  1 
ATOM   4196 C C   . CYS B 2 271 ? 176.380 189.895 180.078 1.00 53.83  ? 271 CYS C C   1 
ATOM   4197 O O   . CYS B 2 271 ? 177.367 189.796 180.810 1.00 53.83  ? 271 CYS C O   1 
ATOM   4198 C CB  . CYS B 2 271 ? 176.407 189.039 177.731 1.00 53.83  ? 271 CYS C CB  1 
ATOM   4199 S SG  . CYS B 2 271 ? 177.376 187.650 178.340 1.00 53.83  ? 271 CYS C SG  1 
ATOM   4200 N N   . GLY B 2 272 ? 175.142 189.664 180.496 1.00 48.47  ? 272 GLY C N   1 
ATOM   4201 C CA  . GLY B 2 272 ? 174.880 189.390 181.891 1.00 48.47  ? 272 GLY C CA  1 
ATOM   4202 C C   . GLY B 2 272 ? 175.223 187.969 182.291 1.00 48.47  ? 272 GLY C C   1 
ATOM   4203 O O   . GLY B 2 272 ? 175.524 187.104 181.470 1.00 48.47  ? 272 GLY C O   1 
ATOM   4204 N N   . ILE B 2 273 ? 175.166 187.738 183.598 1.00 41.42  ? 273 ILE C N   1 
ATOM   4205 C CA  . ILE B 2 273 ? 175.406 186.435 184.204 1.00 41.42  ? 273 ILE C CA  1 
ATOM   4206 C C   . ILE B 2 273 ? 174.072 185.889 184.685 1.00 41.42  ? 273 ILE C C   1 
ATOM   4207 O O   . ILE B 2 273 ? 173.306 186.604 185.340 1.00 41.42  ? 273 ILE C O   1 
ATOM   4208 C CB  . ILE B 2 273 ? 176.408 186.531 185.369 1.00 41.42  ? 273 ILE C CB  1 
ATOM   4209 C CG1 . ILE B 2 273 ? 177.797 186.976 184.902 1.00 41.42  ? 273 ILE C CG1 1 
ATOM   4210 C CG2 . ILE B 2 273 ? 176.477 185.230 186.135 1.00 41.42  ? 273 ILE C CG2 1 
ATOM   4211 C CD1 . ILE B 2 273 ? 178.037 188.462 184.911 1.00 41.42  ? 273 ILE C CD1 1 
ATOM   4212 N N   . THR B 2 274 ? 173.775 184.634 184.351 1.00 38.57  ? 274 THR C N   1 
ATOM   4213 C CA  . THR B 2 274 ? 172.534 184.020 184.804 1.00 38.57  ? 274 THR C CA  1 
ATOM   4214 C C   . THR B 2 274 ? 172.708 183.078 185.983 1.00 38.57  ? 274 THR C C   1 
ATOM   4215 O O   . THR B 2 274 ? 171.755 182.884 186.743 1.00 38.57  ? 274 THR C O   1 
ATOM   4216 C CB  . THR B 2 274 ? 171.858 183.262 183.661 1.00 38.57  ? 274 THR C CB  1 
ATOM   4217 O OG1 . THR B 2 274 ? 172.776 182.318 183.093 1.00 38.57  ? 274 THR C OG1 1 
ATOM   4218 C CG2 . THR B 2 274 ? 171.390 184.228 182.602 1.00 38.57  ? 274 THR C CG2 1 
ATOM   4219 N N   . SER B 2 275 ? 173.884 182.482 186.160 1.00 38.94  ? 275 SER C N   1 
ATOM   4220 C CA  . SER B 2 275 ? 174.103 181.607 187.299 1.00 38.94  ? 275 SER C CA  1 
ATOM   4221 C C   . SER B 2 275 ? 175.584 181.561 187.633 1.00 38.94  ? 275 SER C C   1 
ATOM   4222 O O   . SER B 2 275 ? 176.441 181.703 186.757 1.00 38.94  ? 275 SER C O   1 
ATOM   4223 C CB  . SER B 2 275 ? 173.567 180.198 187.041 1.00 38.94  ? 275 SER C CB  1 
ATOM   4224 O OG  . SER B 2 275 ? 172.151 180.202 187.082 1.00 38.94  ? 275 SER C OG  1 
ATOM   4225 N N   . VAL B 2 276 ? 175.870 181.377 188.919 1.00 40.83  ? 276 VAL C N   1 
ATOM   4226 C CA  . VAL B 2 276 ? 177.225 181.301 189.447 1.00 40.83  ? 276 VAL C CA  1 
ATOM   4227 C C   . VAL B 2 276 ? 177.248 180.235 190.534 1.00 40.83  ? 276 VAL C C   1 
ATOM   4228 O O   . VAL B 2 276 ? 176.382 180.226 191.415 1.00 40.83  ? 276 VAL C O   1 
ATOM   4229 C CB  . VAL B 2 276 ? 177.691 182.667 189.991 1.00 40.83  ? 276 VAL C CB  1 
ATOM   4230 C CG1 . VAL B 2 276 ? 178.792 182.514 190.981 1.00 40.83  ? 276 VAL C CG1 1 
ATOM   4231 C CG2 . VAL B 2 276 ? 178.197 183.526 188.867 1.00 40.83  ? 276 VAL C CG2 1 
ATOM   4232 N N   . SER B 2 277 ? 178.225 179.329 190.465 1.00 44.16  ? 277 SER C N   1 
ATOM   4233 C CA  . SER B 2 277 ? 178.392 178.312 191.494 1.00 44.16  ? 277 SER C CA  1 
ATOM   4234 C C   . SER B 2 277 ? 179.872 178.002 191.669 1.00 44.16  ? 277 SER C C   1 
ATOM   4235 O O   . SER B 2 277 ? 180.687 178.274 190.784 1.00 44.16  ? 277 SER C O   1 
ATOM   4236 C CB  . SER B 2 277 ? 177.619 177.035 191.156 1.00 44.16  ? 277 SER C CB  1 
ATOM   4237 O OG  . SER B 2 277 ? 177.558 176.177 192.279 1.00 44.16  ? 277 SER C OG  1 
ATOM   4238 N N   . PHE B 2 278 ? 180.208 177.439 192.825 1.00 50.57  ? 278 PHE C N   1 
ATOM   4239 C CA  . PHE B 2 278 ? 181.572 177.055 193.161 1.00 50.57  ? 278 PHE C CA  1 
ATOM   4240 C C   . PHE B 2 278 ? 181.772 175.547 193.064 1.00 50.57  ? 278 PHE C C   1 
ATOM   4241 O O   . PHE B 2 278 ? 180.830 174.759 193.173 1.00 50.57  ? 278 PHE C O   1 
ATOM   4242 C CB  . PHE B 2 278 ? 181.940 177.498 194.579 1.00 50.57  ? 278 PHE C CB  1 
ATOM   4243 C CG  . PHE B 2 278 ? 182.358 178.931 194.694 1.00 50.57  ? 278 PHE C CG  1 
ATOM   4244 C CD1 . PHE B 2 278 ? 183.639 179.320 194.334 1.00 50.57  ? 278 PHE C CD1 1 
ATOM   4245 C CD2 . PHE B 2 278 ? 181.506 179.873 195.233 1.00 50.57  ? 278 PHE C CD2 1 
ATOM   4246 C CE1 . PHE B 2 278 ? 184.044 180.637 194.463 1.00 50.57  ? 278 PHE C CE1 1 
ATOM   4247 C CE2 . PHE B 2 278 ? 181.907 181.186 195.369 1.00 50.57  ? 278 PHE C CE2 1 
ATOM   4248 C CZ  . PHE B 2 278 ? 183.178 181.569 194.982 1.00 50.57  ? 278 PHE C CZ  1 
ATOM   4249 N N   . SER B 2 279 ? 183.031 175.155 192.872 1.00 56.79  ? 279 SER C N   1 
ATOM   4250 C CA  . SER B 2 279 ? 183.441 173.780 193.115 1.00 56.79  ? 279 SER C CA  1 
ATOM   4251 C C   . SER B 2 279 ? 183.719 173.588 194.606 1.00 56.79  ? 279 SER C C   1 
ATOM   4252 O O   . SER B 2 279 ? 183.664 174.532 195.399 1.00 56.79  ? 279 SER C O   1 
ATOM   4253 C CB  . SER B 2 279 ? 184.672 173.426 192.281 1.00 56.79  ? 279 SER C CB  1 
ATOM   4254 O OG  . SER B 2 279 ? 185.706 174.377 192.463 1.00 56.79  ? 279 SER C OG  1 
ATOM   4255 N N   . LYS B 2 280 ? 184.023 172.347 194.994 1.00 54.75  ? 280 LYS C N   1 
ATOM   4256 C CA  . LYS B 2 280 ? 184.159 172.066 196.420 1.00 54.75  ? 280 LYS C CA  1 
ATOM   4257 C C   . LYS B 2 280 ? 185.478 172.568 196.994 1.00 54.75  ? 280 LYS C C   1 
ATOM   4258 O O   . LYS B 2 280 ? 185.614 172.640 198.220 1.00 54.75  ? 280 LYS C O   1 
ATOM   4259 C CB  . LYS B 2 280 ? 184.013 170.569 196.700 1.00 54.75  ? 280 LYS C CB  1 
ATOM   4260 C CG  . LYS B 2 280 ? 185.276 169.759 196.496 1.00 54.75  ? 280 LYS C CG  1 
ATOM   4261 C CD  . LYS B 2 280 ? 185.027 168.299 196.816 1.00 54.75  ? 280 LYS C CD  1 
ATOM   4262 C CE  . LYS B 2 280 ? 184.698 168.114 198.287 1.00 54.75  ? 280 LYS C CE  1 
ATOM   4263 N NZ  . LYS B 2 280 ? 184.465 166.684 198.627 1.00 54.75  ? 280 LYS C NZ  1 
ATOM   4264 N N   . SER B 2 281 ? 186.449 172.910 196.151 1.00 52.16  ? 281 SER C N   1 
ATOM   4265 C CA  . SER B 2 281 ? 187.678 173.517 196.638 1.00 52.16  ? 281 SER C CA  1 
ATOM   4266 C C   . SER B 2 281 ? 187.585 175.029 196.743 1.00 52.16  ? 281 SER C C   1 
ATOM   4267 O O   . SER B 2 281 ? 188.303 175.627 197.552 1.00 52.16  ? 281 SER C O   1 
ATOM   4268 C CB  . SER B 2 281 ? 188.850 173.157 195.725 1.00 52.16  ? 281 SER C CB  1 
ATOM   4269 O OG  . SER B 2 281 ? 188.655 173.678 194.425 1.00 52.16  ? 281 SER C OG  1 
ATOM   4270 N N   . GLY B 2 282 ? 186.723 175.656 195.950 1.00 55.71  ? 282 GLY C N   1 
ATOM   4271 C CA  . GLY B 2 282 ? 186.583 177.093 195.961 1.00 55.71  ? 282 GLY C CA  1 
ATOM   4272 C C   . GLY B 2 282 ? 187.611 177.848 195.151 1.00 55.71  ? 282 GLY C C   1 
ATOM   4273 O O   . GLY B 2 282 ? 187.563 179.083 195.126 1.00 55.71  ? 282 GLY C O   1 
ATOM   4274 N N   . ARG B 2 283 ? 188.551 177.158 194.502 1.00 57.93  ? 283 ARG C N   1 
ATOM   4275 C CA  . ARG B 2 283 ? 189.544 177.851 193.689 1.00 57.93  ? 283 ARG C CA  1 
ATOM   4276 C C   . ARG B 2 283 ? 188.941 178.356 192.386 1.00 57.93  ? 283 ARG C C   1 
ATOM   4277 O O   . ARG B 2 283 ? 189.247 179.468 191.943 1.00 57.93  ? 283 ARG C O   1 
ATOM   4278 C CB  . ARG B 2 283 ? 190.730 176.930 193.409 1.00 57.93  ? 283 ARG C CB  1 
ATOM   4279 C CG  . ARG B 2 283 ? 191.837 177.574 192.596 1.00 57.93  ? 283 ARG C CG  1 
ATOM   4280 C CD  . ARG B 2 283 ? 192.301 178.874 193.219 1.00 57.93  ? 283 ARG C CD  1 
ATOM   4281 N NE  . ARG B 2 283 ? 193.392 179.472 192.463 1.00 57.93  ? 283 ARG C NE  1 
ATOM   4282 C CZ  . ARG B 2 283 ? 194.676 179.320 192.750 1.00 57.93  ? 283 ARG C CZ  1 
ATOM   4283 N NH1 . ARG B 2 283 ? 195.071 178.612 193.794 1.00 57.93  ? 283 ARG C NH1 1 
ATOM   4284 N NH2 . ARG B 2 283 ? 195.588 179.892 191.969 1.00 57.93  ? 283 ARG C NH2 1 
ATOM   4285 N N   . LEU B 2 284 ? 188.090 177.557 191.756 1.00 52.63  ? 284 LEU C N   1 
ATOM   4286 C CA  . LEU B 2 284 ? 187.470 177.925 190.492 1.00 52.63  ? 284 LEU C CA  1 
ATOM   4287 C C   . LEU B 2 284 ? 186.060 178.442 190.729 1.00 52.63  ? 284 LEU C C   1 
ATOM   4288 O O   . LEU B 2 284 ? 185.285 177.836 191.477 1.00 52.63  ? 284 LEU C O   1 
ATOM   4289 C CB  . LEU B 2 284 ? 187.445 176.742 189.524 1.00 52.63  ? 284 LEU C CB  1 
ATOM   4290 C CG  . LEU B 2 284 ? 188.541 176.764 188.459 1.00 52.63  ? 284 LEU C CG  1 
ATOM   4291 C CD1 . LEU B 2 284 ? 189.911 176.556 189.075 1.00 52.63  ? 284 LEU C CD1 1 
ATOM   4292 C CD2 . LEU B 2 284 ? 188.264 175.717 187.397 1.00 52.63  ? 284 LEU C CD2 1 
ATOM   4293 N N   . LEU B 2 285 ? 185.740 179.564 190.095 1.00 50.01  ? 285 LEU C N   1 
ATOM   4294 C CA  . LEU B 2 285 ? 184.407 180.147 190.113 1.00 50.01  ? 285 LEU C CA  1 
ATOM   4295 C C   . LEU B 2 285 ? 183.813 180.042 188.717 1.00 50.01  ? 285 LEU C C   1 
ATOM   4296 O O   . LEU B 2 285 ? 184.400 180.543 187.754 1.00 50.01  ? 285 LEU C O   1 
ATOM   4297 C CB  . LEU B 2 285 ? 184.451 181.605 190.561 1.00 50.01  ? 285 LEU C CB  1 
ATOM   4298 C CG  . LEU B 2 285 ? 183.072 182.248 190.575 1.00 50.01  ? 285 LEU C CG  1 
ATOM   4299 C CD1 . LEU B 2 285 ? 182.192 181.479 191.528 1.00 50.01  ? 285 LEU C CD1 1 
ATOM   4300 C CD2 . LEU B 2 285 ? 183.166 183.698 190.982 1.00 50.01  ? 285 LEU C CD2 1 
ATOM   4301 N N   . LEU B 2 286 ? 182.652 179.409 188.609 1.00 47.88  ? 286 LEU C N   1 
ATOM   4302 C CA  . LEU B 2 286 ? 182.028 179.154 187.319 1.00 47.88  ? 286 LEU C CA  1 
ATOM   4303 C C   . LEU B 2 286 ? 180.900 180.152 187.115 1.00 47.88  ? 286 LEU C C   1 
ATOM   4304 O O   . LEU B 2 286 ? 179.931 180.162 187.881 1.00 47.88  ? 286 LEU C O   1 
ATOM   4305 C CB  . LEU B 2 286 ? 181.512 177.719 187.228 1.00 47.88  ? 286 LEU C CB  1 
ATOM   4306 C CG  . LEU B 2 286 ? 182.579 176.672 186.889 1.00 47.88  ? 286 LEU C CG  1 
ATOM   4307 C CD1 . LEU B 2 286 ? 183.343 176.205 188.126 1.00 47.88  ? 286 LEU C CD1 1 
ATOM   4308 C CD2 . LEU B 2 286 ? 181.976 175.496 186.150 1.00 47.88  ? 286 LEU C CD2 1 
ATOM   4309 N N   . ALA B 2 287 ? 181.027 180.983 186.084 1.00 43.89  ? 287 ALA C N   1 
ATOM   4310 C CA  . ALA B 2 287 ? 180.078 182.054 185.818 1.00 43.89  ? 287 ALA C CA  1 
ATOM   4311 C C   . ALA B 2 287 ? 179.397 181.809 184.484 1.00 43.89  ? 287 ALA C C   1 
ATOM   4312 O O   . ALA B 2 287 ? 180.061 181.770 183.445 1.00 43.89  ? 287 ALA C O   1 
ATOM   4313 C CB  . ALA B 2 287 ? 180.774 183.416 185.804 1.00 43.89  ? 287 ALA C CB  1 
ATOM   4314 N N   . GLY B 2 288 ? 178.079 181.648 184.512 1.00 41.54  ? 288 GLY C N   1 
ATOM   4315 C CA  . GLY B 2 288 ? 177.324 181.593 183.282 1.00 41.54  ? 288 GLY C CA  1 
ATOM   4316 C C   . GLY B 2 288 ? 177.245 182.955 182.627 1.00 41.54  ? 288 GLY C C   1 
ATOM   4317 O O   . GLY B 2 288 ? 177.485 183.989 183.248 1.00 41.54  ? 288 GLY C O   1 
ATOM   4318 N N   . TYR B 2 289 ? 176.904 182.959 181.342 1.00 43.79  ? 289 TYR C N   1 
ATOM   4319 C CA  . TYR B 2 289 ? 176.876 184.208 180.599 1.00 43.79  ? 289 TYR C CA  1 
ATOM   4320 C C   . TYR B 2 289 ? 175.777 184.163 179.550 1.00 43.79  ? 289 TYR C C   1 
ATOM   4321 O O   . TYR B 2 289 ? 175.303 183.093 179.161 1.00 43.79  ? 289 TYR C O   1 
ATOM   4322 C CB  . TYR B 2 289 ? 178.231 184.500 179.945 1.00 43.79  ? 289 TYR C CB  1 
ATOM   4323 C CG  . TYR B 2 289 ? 179.239 185.094 180.894 1.00 43.79  ? 289 TYR C CG  1 
ATOM   4324 C CD1 . TYR B 2 289 ? 179.255 186.453 181.154 1.00 43.79  ? 289 TYR C CD1 1 
ATOM   4325 C CD2 . TYR B 2 289 ? 180.170 184.296 181.535 1.00 43.79  ? 289 TYR C CD2 1 
ATOM   4326 C CE1 . TYR B 2 289 ? 180.171 187.002 182.026 1.00 43.79  ? 289 TYR C CE1 1 
ATOM   4327 C CE2 . TYR B 2 289 ? 181.089 184.833 182.412 1.00 43.79  ? 289 TYR C CE2 1 
ATOM   4328 C CZ  . TYR B 2 289 ? 181.087 186.190 182.651 1.00 43.79  ? 289 TYR C CZ  1 
ATOM   4329 O OH  . TYR B 2 289 ? 182.003 186.731 183.524 1.00 43.79  ? 289 TYR C OH  1 
ATOM   4330 N N   . ASP B 2 290 ? 175.374 185.350 179.099 1.00 47.25  ? 290 ASP C N   1 
ATOM   4331 C CA  . ASP B 2 290 ? 174.444 185.496 177.989 1.00 47.25  ? 290 ASP C CA  1 
ATOM   4332 C C   . ASP B 2 290 ? 175.151 185.526 176.644 1.00 47.25  ? 290 ASP C C   1 
ATOM   4333 O O   . ASP B 2 290 ? 174.500 185.751 175.620 1.00 47.25  ? 290 ASP C O   1 
ATOM   4334 C CB  . ASP B 2 290 ? 173.607 186.765 178.158 1.00 47.25  ? 290 ASP C CB  1 
ATOM   4335 C CG  . ASP B 2 290 ? 172.949 186.844 179.510 1.00 47.25  ? 290 ASP C CG  1 
ATOM   4336 O OD1 . ASP B 2 290 ? 172.796 185.784 180.145 1.00 47.25  ? 290 ASP C OD1 1 
ATOM   4337 O OD2 . ASP B 2 290 ? 172.586 187.959 179.938 1.00 47.25  ? 290 ASP C OD2 1 
ATOM   4338 N N   . ASP B 2 291 ? 176.464 185.300 176.626 1.00 49.26  ? 291 ASP C N   1 
ATOM   4339 C CA  . ASP B 2 291 ? 177.250 185.177 175.407 1.00 49.26  ? 291 ASP C CA  1 
ATOM   4340 C C   . ASP B 2 291 ? 177.200 183.777 174.818 1.00 49.26  ? 291 ASP C C   1 
ATOM   4341 O O   . ASP B 2 291 ? 178.144 183.391 174.115 1.00 49.26  ? 291 ASP C O   1 
ATOM   4342 C CB  . ASP B 2 291 ? 178.706 185.572 175.670 1.00 49.26  ? 291 ASP C CB  1 
ATOM   4343 C CG  . ASP B 2 291 ? 178.998 187.007 175.296 1.00 49.26  ? 291 ASP C CG  1 
ATOM   4344 O OD1 . ASP B 2 291 ? 178.046 187.749 174.984 1.00 49.26  ? 291 ASP C OD1 1 
ATOM   4345 O OD2 . ASP B 2 291 ? 180.185 187.392 175.311 1.00 49.26  ? 291 ASP C OD2 1 
ATOM   4346 N N   . PHE B 2 292 ? 176.147 183.016 175.138 1.00 49.41  ? 292 PHE C N   1 
ATOM   4347 C CA  . PHE B 2 292 ? 175.889 181.680 174.602 1.00 49.41  ? 292 PHE C CA  1 
ATOM   4348 C C   . PHE B 2 292 ? 176.971 180.684 175.005 1.00 49.41  ? 292 PHE C C   1 
ATOM   4349 O O   . PHE B 2 292 ? 177.273 179.751 174.258 1.00 49.41  ? 292 PHE C O   1 
ATOM   4350 C CB  . PHE B 2 292 ? 175.727 181.701 173.074 1.00 49.41  ? 292 PHE C CB  1 
ATOM   4351 C CG  . PHE B 2 292 ? 174.362 182.131 172.598 1.00 49.41  ? 292 PHE C CG  1 
ATOM   4352 C CD1 . PHE B 2 292 ? 173.559 182.960 173.367 1.00 49.41  ? 292 PHE C CD1 1 
ATOM   4353 C CD2 . PHE B 2 292 ? 173.902 181.732 171.356 1.00 49.41  ? 292 PHE C CD2 1 
ATOM   4354 C CE1 . PHE B 2 292 ? 172.315 183.356 172.920 1.00 49.41  ? 292 PHE C CE1 1 
ATOM   4355 C CE2 . PHE B 2 292 ? 172.660 182.132 170.901 1.00 49.41  ? 292 PHE C CE2 1 
ATOM   4356 C CZ  . PHE B 2 292 ? 171.866 182.943 171.684 1.00 49.41  ? 292 PHE C CZ  1 
ATOM   4357 N N   . ASN B 2 293 ? 177.563 180.866 176.182 1.00 44.82  ? 293 ASN C N   1 
ATOM   4358 C CA  . ASN B 2 293 ? 178.622 179.980 176.647 1.00 44.82  ? 293 ASN C CA  1 
ATOM   4359 C C   . ASN B 2 293 ? 178.666 180.020 178.170 1.00 44.82  ? 293 ASN C C   1 
ATOM   4360 O O   . ASN B 2 293 ? 177.789 180.598 178.822 1.00 44.82  ? 293 ASN C O   1 
ATOM   4361 C CB  . ASN B 2 293 ? 179.972 180.372 176.035 1.00 44.82  ? 293 ASN C CB  1 
ATOM   4362 C CG  . ASN B 2 293 ? 180.338 181.817 176.300 1.00 44.82  ? 293 ASN C CG  1 
ATOM   4363 O OD1 . ASN B 2 293 ? 179.522 182.600 176.778 1.00 44.82  ? 293 ASN C OD1 1 
ATOM   4364 N ND2 . ASN B 2 293 ? 181.578 182.178 175.992 1.00 44.82  ? 293 ASN C ND2 1 
ATOM   4365 N N   . CYS B 2 294 ? 179.694 179.394 178.735 1.00 42.34  ? 294 CYS C N   1 
ATOM   4366 C CA  . CYS B 2 294 ? 179.993 179.461 180.155 1.00 42.34  ? 294 CYS C CA  1 
ATOM   4367 C C   . CYS B 2 294 ? 181.481 179.725 180.314 1.00 42.34  ? 294 CYS C C   1 
ATOM   4368 O O   . CYS B 2 294 ? 182.296 179.253 179.518 1.00 42.34  ? 294 CYS C O   1 
ATOM   4369 C CB  . CYS B 2 294 ? 179.604 178.169 180.882 1.00 42.34  ? 294 CYS C CB  1 
ATOM   4370 S SG  . CYS B 2 294 ? 180.302 178.008 182.536 1.00 42.34  ? 294 CYS C SG  1 
ATOM   4371 N N   . ASN B 2 295 ? 181.833 180.483 181.343 1.00 46.32  ? 295 ASN C N   1 
ATOM   4372 C CA  . ASN B 2 295 ? 183.217 180.849 181.592 1.00 46.32  ? 295 ASN C CA  1 
ATOM   4373 C C   . ASN B 2 295 ? 183.566 180.604 183.052 1.00 46.32  ? 295 ASN C C   1 
ATOM   4374 O O   . ASN B 2 295 ? 182.782 180.927 183.950 1.00 46.32  ? 295 ASN C O   1 
ATOM   4375 C CB  . ASN B 2 295 ? 183.469 182.310 181.230 1.00 46.32  ? 295 ASN C CB  1 
ATOM   4376 N N   . VAL B 2 296 ? 184.746 180.032 183.284 1.00 52.61  ? 296 VAL C N   1 
ATOM   4377 C CA  . VAL B 2 296 ? 185.242 179.760 184.629 1.00 52.61  ? 296 VAL C CA  1 
ATOM   4378 C C   . VAL B 2 296 ? 186.203 180.868 185.030 1.00 52.61  ? 296 VAL C C   1 
ATOM   4379 O O   . VAL B 2 296 ? 186.743 181.582 184.175 1.00 52.61  ? 296 VAL C O   1 
ATOM   4380 C CB  . VAL B 2 296 ? 185.909 178.375 184.709 1.00 52.61  ? 296 VAL C CB  1 
ATOM   4381 C CG1 . VAL B 2 296 ? 184.992 177.323 184.123 1.00 52.61  ? 296 VAL C CG1 1 
ATOM   4382 C CG2 . VAL B 2 296 ? 187.225 178.379 183.976 1.00 52.61  ? 296 VAL C CG2 1 
ATOM   4383 N N   . TRP B 2 297 ? 186.401 181.032 186.335 1.00 56.96  ? 297 TRP C N   1 
ATOM   4384 C CA  . TRP B 2 297 ? 187.152 182.157 186.873 1.00 56.96  ? 297 TRP C CA  1 
ATOM   4385 C C   . TRP B 2 297 ? 188.021 181.699 188.031 1.00 56.96  ? 297 TRP C C   1 
ATOM   4386 O O   . TRP B 2 297 ? 187.597 180.868 188.840 1.00 56.96  ? 297 TRP C O   1 
ATOM   4387 C CB  . TRP B 2 297 ? 186.207 183.258 187.352 1.00 56.96  ? 297 TRP C CB  1 
ATOM   4388 C CG  . TRP B 2 297 ? 185.535 183.998 186.253 1.00 56.96  ? 297 TRP C CG  1 
ATOM   4389 C CD1 . TRP B 2 297 ? 184.290 183.766 185.753 1.00 56.96  ? 297 TRP C CD1 1 
ATOM   4390 C CD2 . TRP B 2 297 ? 186.060 185.112 185.525 1.00 56.96  ? 297 TRP C CD2 1 
ATOM   4391 N NE1 . TRP B 2 297 ? 184.008 184.660 184.751 1.00 56.96  ? 297 TRP C NE1 1 
ATOM   4392 C CE2 . TRP B 2 297 ? 185.080 185.498 184.592 1.00 56.96  ? 297 TRP C CE2 1 
ATOM   4393 C CE3 . TRP B 2 297 ? 187.265 185.817 185.569 1.00 56.96  ? 297 TRP C CE3 1 
ATOM   4394 C CZ2 . TRP B 2 297 ? 185.269 186.559 183.711 1.00 56.96  ? 297 TRP C CZ2 1 
ATOM   4395 C CZ3 . TRP B 2 297 ? 187.451 186.867 184.695 1.00 56.96  ? 297 TRP C CZ3 1 
ATOM   4396 C CH2 . TRP B 2 297 ? 186.459 187.228 183.778 1.00 56.96  ? 297 TRP C CH2 1 
ATOM   4397 N N   . ASP B 2 298 ? 189.226 182.253 188.117 1.00 61.24  ? 298 ASP C N   1 
ATOM   4398 C CA  . ASP B 2 298 ? 190.024 182.107 189.324 1.00 61.24  ? 298 ASP C CA  1 
ATOM   4399 C C   . ASP B 2 298 ? 189.374 182.900 190.445 1.00 61.24  ? 298 ASP C C   1 
ATOM   4400 O O   . ASP B 2 298 ? 189.269 184.127 190.362 1.00 61.24  ? 298 ASP C O   1 
ATOM   4401 C CB  . ASP B 2 298 ? 191.449 182.597 189.091 1.00 61.24  ? 298 ASP C CB  1 
ATOM   4402 C CG  . ASP B 2 298 ? 192.367 181.508 188.591 1.00 61.24  ? 298 ASP C CG  1 
ATOM   4403 O OD1 . ASP B 2 298 ? 191.927 180.342 188.519 1.00 61.24  ? 298 ASP C OD1 1 
ATOM   4404 O OD2 . ASP B 2 298 ? 193.538 181.815 188.288 1.00 61.24  ? 298 ASP C OD2 1 
ATOM   4405 N N   . ALA B 2 299 ? 188.950 182.209 191.502 1.00 63.44  ? 299 ALA C N   1 
ATOM   4406 C CA  . ALA B 2 299 ? 188.299 182.891 192.612 1.00 63.44  ? 299 ALA C CA  1 
ATOM   4407 C C   . ALA B 2 299 ? 189.261 183.733 193.435 1.00 63.44  ? 299 ALA C C   1 
ATOM   4408 O O   . ALA B 2 299 ? 188.809 184.491 194.299 1.00 63.44  ? 299 ALA C O   1 
ATOM   4409 C CB  . ALA B 2 299 ? 187.592 181.884 193.516 1.00 63.44  ? 299 ALA C CB  1 
ATOM   4410 N N   . LEU B 2 300 ? 190.564 183.612 193.202 1.00 72.47  ? 300 LEU C N   1 
ATOM   4411 C CA  . LEU B 2 300 ? 191.568 184.432 193.861 1.00 72.47  ? 300 LEU C CA  1 
ATOM   4412 C C   . LEU B 2 300 ? 192.322 185.326 192.888 1.00 72.47  ? 300 LEU C C   1 
ATOM   4413 O O   . LEU B 2 300 ? 192.559 186.501 193.182 1.00 72.47  ? 300 LEU C O   1 
ATOM   4414 C CB  . LEU B 2 300 ? 192.558 183.544 194.632 1.00 72.47  ? 300 LEU C CB  1 
ATOM   4415 C CG  . LEU B 2 300 ? 192.154 182.992 196.004 1.00 72.47  ? 300 LEU C CG  1 
ATOM   4416 C CD1 . LEU B 2 300 ? 191.109 181.901 195.912 1.00 72.47  ? 300 LEU C CD1 1 
ATOM   4417 C CD2 . LEU B 2 300 ? 193.381 182.484 196.745 1.00 72.47  ? 300 LEU C CD2 1 
ATOM   4418 N N   . LYS B 2 301 ? 192.707 184.798 191.728 1.00 73.36  ? 301 LYS C N   1 
ATOM   4419 C CA  . LYS B 2 301 ? 193.495 185.556 190.768 1.00 73.36  ? 301 LYS C CA  1 
ATOM   4420 C C   . LYS B 2 301 ? 192.649 186.392 189.817 1.00 73.36  ? 301 LYS C C   1 
ATOM   4421 O O   . LYS B 2 301 ? 193.205 187.264 189.137 1.00 73.36  ? 301 LYS C O   1 
ATOM   4422 C CB  . LYS B 2 301 ? 194.384 184.609 189.959 1.00 73.36  ? 301 LYS C CB  1 
ATOM   4423 C CG  . LYS B 2 301 ? 195.060 183.542 190.796 1.00 73.36  ? 301 LYS C CG  1 
ATOM   4424 C CD  . LYS B 2 301 ? 196.353 183.083 190.156 1.00 73.36  ? 301 LYS C CD  1 
ATOM   4425 C CE  . LYS B 2 301 ? 197.346 184.225 190.036 1.00 73.36  ? 301 LYS C CE  1 
ATOM   4426 N NZ  . LYS B 2 301 ? 197.707 184.795 191.362 1.00 73.36  ? 301 LYS C NZ  1 
ATOM   4427 N N   . ALA B 2 302 ? 191.335 186.144 189.763 1.00 68.03  ? 302 ALA C N   1 
ATOM   4428 C CA  . ALA B 2 302 ? 190.382 186.883 188.923 1.00 68.03  ? 302 ALA C CA  1 
ATOM   4429 C C   . ALA B 2 302 ? 190.774 186.861 187.446 1.00 68.03  ? 302 ALA C C   1 
ATOM   4430 O O   . ALA B 2 302 ? 190.698 187.873 186.746 1.00 68.03  ? 302 ALA C O   1 
ATOM   4431 C CB  . ALA B 2 302 ? 190.204 188.319 189.419 1.00 68.03  ? 302 ALA C CB  1 
ATOM   4432 N N   . ASP B 2 303 ? 191.190 185.694 186.965 1.00 61.76  ? 303 ASP C N   1 
ATOM   4433 C CA  . ASP B 2 303 ? 191.546 185.505 185.567 1.00 61.76  ? 303 ASP C CA  1 
ATOM   4434 C C   . ASP B 2 303 ? 190.710 184.386 184.964 1.00 61.76  ? 303 ASP C C   1 
ATOM   4435 O O   . ASP B 2 303 ? 190.216 183.504 185.672 1.00 61.76  ? 303 ASP C O   1 
ATOM   4436 C CB  . ASP B 2 303 ? 193.037 185.182 185.399 1.00 61.76  ? 303 ASP C CB  1 
ATOM   4437 C CG  . ASP B 2 303 ? 193.915 186.415 185.488 1.00 61.76  ? 303 ASP C CG  1 
ATOM   4438 O OD1 . ASP B 2 303 ? 193.369 187.525 185.647 1.00 61.76  ? 303 ASP C OD1 1 
ATOM   4439 O OD2 . ASP B 2 303 ? 195.152 186.274 185.392 1.00 61.76  ? 303 ASP C OD2 1 
ATOM   4440 N N   . ARG B 2 304 ? 190.558 184.435 183.644 1.00 60.81  ? 304 ARG C N   1 
ATOM   4441 C CA  . ARG B 2 304 ? 189.783 183.435 182.921 1.00 60.81  ? 304 ARG C CA  1 
ATOM   4442 C C   . ARG B 2 304 ? 190.605 182.160 182.785 1.00 60.81  ? 304 ARG C C   1 
ATOM   4443 O O   . ARG B 2 304 ? 191.639 182.150 182.109 1.00 60.81  ? 304 ARG C O   1 
ATOM   4444 C CB  . ARG B 2 304 ? 189.380 183.970 181.549 1.00 60.81  ? 304 ARG C CB  1 
ATOM   4445 C CG  . ARG B 2 304 ? 188.170 184.886 181.577 1.00 60.81  ? 304 ARG C CG  1 
ATOM   4446 C CD  . ARG B 2 304 ? 186.883 184.086 181.657 1.00 60.81  ? 304 ARG C CD  1 
ATOM   4447 N NE  . ARG B 2 304 ? 186.333 183.811 180.336 1.00 60.81  ? 304 ARG C NE  1 
ATOM   4448 C CZ  . ARG B 2 304 ? 185.562 184.651 179.661 1.00 60.81  ? 304 ARG C CZ  1 
ATOM   4449 N NH1 . ARG B 2 304 ? 185.217 185.826 180.160 1.00 60.81  ? 304 ARG C NH1 1 
ATOM   4450 N NH2 . ARG B 2 304 ? 185.121 184.302 178.456 1.00 60.81  ? 304 ARG C NH2 1 
ATOM   4451 N N   . ALA B 2 305 ? 190.150 181.089 183.428 1.00 60.48  ? 305 ALA C N   1 
ATOM   4452 C CA  . ALA B 2 305 ? 190.854 179.816 183.406 1.00 60.48  ? 305 ALA C CA  1 
ATOM   4453 C C   . ALA B 2 305 ? 190.332 178.867 182.338 1.00 60.48  ? 305 ALA C C   1 
ATOM   4454 O O   . ALA B 2 305 ? 190.790 177.722 182.270 1.00 60.48  ? 305 ALA C O   1 
ATOM   4455 C CB  . ALA B 2 305 ? 190.775 179.144 184.781 1.00 60.48  ? 305 ALA C CB  1 
ATOM   4456 N N   . GLY B 2 306 ? 189.396 179.302 181.515 1.00 55.35  ? 306 GLY C N   1 
ATOM   4457 C CA  . GLY B 2 306 ? 188.842 178.465 180.469 1.00 55.35  ? 306 GLY C CA  1 
ATOM   4458 C C   . GLY B 2 306 ? 187.427 178.879 180.130 1.00 55.35  ? 306 GLY C C   1 
ATOM   4459 O O   . GLY B 2 306 ? 186.738 179.556 180.890 1.00 55.35  ? 306 GLY C O   1 
ATOM   4460 N N   . VAL B 2 307 ? 186.986 178.464 178.946 1.00 43.04  ? 307 VAL C N   1 
ATOM   4461 C CA  . VAL B 2 307 ? 185.652 178.763 178.442 1.00 43.04  ? 307 VAL C CA  1 
ATOM   4462 C C   . VAL B 2 307 ? 184.965 177.453 178.098 1.00 43.04  ? 307 VAL C C   1 
ATOM   4463 O O   . VAL B 2 307 ? 185.493 176.659 177.313 1.00 43.04  ? 307 VAL C O   1 
ATOM   4464 C CB  . VAL B 2 307 ? 185.702 179.684 177.209 1.00 43.04  ? 307 VAL C CB  1 
ATOM   4465 C CG1 . VAL B 2 307 ? 184.298 179.953 176.692 1.00 43.04  ? 307 VAL C CG1 1 
ATOM   4466 C CG2 . VAL B 2 307 ? 186.415 180.989 177.539 1.00 43.04  ? 307 VAL C CG2 1 
ATOM   4467 N N   . LEU B 2 308 ? 183.790 177.231 178.675 1.00 38.63  ? 308 LEU C N   1 
ATOM   4468 C CA  . LEU B 2 308 ? 182.974 176.071 178.325 1.00 38.63  ? 308 LEU C CA  1 
ATOM   4469 C C   . LEU B 2 308 ? 181.984 176.417 177.220 1.00 38.63  ? 308 LEU C C   1 
ATOM   4470 O O   . LEU B 2 308 ? 180.771 176.285 177.378 1.00 38.63  ? 308 LEU C O   1 
ATOM   4471 C CB  . LEU B 2 308 ? 182.254 175.538 179.556 1.00 38.63  ? 308 LEU C CB  1 
ATOM   4472 C CG  . LEU B 2 308 ? 183.106 175.154 180.762 1.00 38.63  ? 308 LEU C CG  1 
ATOM   4473 C CD1 . LEU B 2 308 ? 182.279 174.360 181.751 1.00 38.63  ? 308 LEU C CD1 1 
ATOM   4474 C CD2 . LEU B 2 308 ? 184.318 174.366 180.331 1.00 38.63  ? 308 LEU C CD2 1 
ATOM   4475 N N   . ALA B 2 309 ? 182.507 176.888 176.092 1.00 43.45  ? 309 ALA C N   1 
ATOM   4476 C CA  . ALA B 2 309 ? 181.668 177.204 174.948 1.00 43.45  ? 309 ALA C CA  1 
ATOM   4477 C C   . ALA B 2 309 ? 181.077 175.934 174.350 1.00 43.45  ? 309 ALA C C   1 
ATOM   4478 O O   . ALA B 2 309 ? 181.648 174.846 174.455 1.00 43.45  ? 309 ALA C O   1 
ATOM   4479 C CB  . ALA B 2 309 ? 182.470 177.955 173.888 1.00 43.45  ? 309 ALA C CB  1 
ATOM   4480 N N   . GLY B 2 310 ? 179.918 176.080 173.718 1.00 42.85  ? 310 GLY C N   1 
ATOM   4481 C CA  . GLY B 2 310 ? 179.275 174.948 173.087 1.00 42.85  ? 310 GLY C CA  1 
ATOM   4482 C C   . GLY B 2 310 ? 177.764 174.966 173.149 1.00 42.85  ? 310 GLY C C   1 
ATOM   4483 O O   . GLY B 2 310 ? 177.109 174.161 172.481 1.00 42.85  ? 310 GLY C O   1 
ATOM   4484 N N   . HIS B 2 311 ? 177.191 175.875 173.932 1.00 42.50  ? 311 HIS C N   1 
ATOM   4485 C CA  . HIS B 2 311 ? 175.744 176.019 173.983 1.00 42.50  ? 311 HIS C CA  1 
ATOM   4486 C C   . HIS B 2 311 ? 175.243 176.809 172.785 1.00 42.50  ? 311 HIS C C   1 
ATOM   4487 O O   . HIS B 2 311 ? 175.855 177.797 172.372 1.00 42.50  ? 311 HIS C O   1 
ATOM   4488 C CB  . HIS B 2 311 ? 175.291 176.696 175.275 1.00 42.50  ? 311 HIS C CB  1 
ATOM   4489 C CG  . HIS B 2 311 ? 175.285 175.784 176.459 1.00 42.50  ? 311 HIS C CG  1 
ATOM   4490 N ND1 . HIS B 2 311 ? 174.312 174.828 176.649 1.00 42.50  ? 311 HIS C ND1 1 
ATOM   4491 C CD2 . HIS B 2 311 ? 176.122 175.688 177.517 1.00 42.50  ? 311 HIS C CD2 1 
ATOM   4492 C CE1 . HIS B 2 311 ? 174.554 174.175 177.771 1.00 42.50  ? 311 HIS C CE1 1 
ATOM   4493 N NE2 . HIS B 2 311 ? 175.646 174.678 178.318 1.00 42.50  ? 311 HIS C NE2 1 
ATOM   4494 N N   . ASP B 2 312 ? 174.123 176.354 172.227 1.00 48.05  ? 312 ASP C N   1 
ATOM   4495 C CA  . ASP B 2 312 ? 173.513 177.035 171.094 1.00 48.05  ? 312 ASP C CA  1 
ATOM   4496 C C   . ASP B 2 312 ? 172.706 178.252 171.526 1.00 48.05  ? 312 ASP C C   1 
ATOM   4497 O O   . ASP B 2 312 ? 172.270 179.025 170.667 1.00 48.05  ? 312 ASP C O   1 
ATOM   4498 C CB  . ASP B 2 312 ? 172.627 176.055 170.322 1.00 48.05  ? 312 ASP C CB  1 
ATOM   4499 C CG  . ASP B 2 312 ? 172.441 176.450 168.871 1.00 48.05  ? 312 ASP C CG  1 
ATOM   4500 O OD1 . ASP B 2 312 ? 173.083 177.424 168.426 1.00 48.05  ? 312 ASP C OD1 1 
ATOM   4501 O OD2 . ASP B 2 312 ? 171.653 175.780 168.172 1.00 48.05  ? 312 ASP C OD2 1 
ATOM   4502 N N   . ASN B 2 313 ? 172.484 178.433 172.829 1.00 44.31  ? 313 ASN C N   1 
ATOM   4503 C CA  . ASN B 2 313 ? 171.725 179.578 173.319 1.00 44.31  ? 313 ASN C CA  1 
ATOM   4504 C C   . ASN B 2 313 ? 172.284 180.075 174.648 1.00 44.31  ? 313 ASN C C   1 
ATOM   4505 O O   . ASN B 2 313 ? 173.327 179.603 175.108 1.00 44.31  ? 313 ASN C O   1 
ATOM   4506 C CB  . ASN B 2 313 ? 170.246 179.211 173.457 1.00 44.31  ? 313 ASN C CB  1 
ATOM   4507 C CG  . ASN B 2 313 ? 169.325 180.369 173.136 1.00 44.31  ? 313 ASN C CG  1 
ATOM   4508 O OD1 . ASN B 2 313 ? 169.615 181.517 173.467 1.00 44.31  ? 313 ASN C OD1 1 
ATOM   4509 N ND2 . ASN B 2 313 ? 168.211 180.073 172.478 1.00 44.31  ? 313 ASN C ND2 1 
ATOM   4510 N N   . ARG B 2 314 ? 171.599 181.033 175.266 1.00 44.23  ? 314 ARG C N   1 
ATOM   4511 C CA  . ARG B 2 314 ? 172.060 181.616 176.518 1.00 44.23  ? 314 ARG C CA  1 
ATOM   4512 C C   . ARG B 2 314 ? 171.851 180.635 177.667 1.00 44.23  ? 314 ARG C C   1 
ATOM   4513 O O   . ARG B 2 314 ? 170.796 180.001 177.768 1.00 44.23  ? 314 ARG C O   1 
ATOM   4514 C CB  . ARG B 2 314 ? 171.309 182.923 176.779 1.00 44.23  ? 314 ARG C CB  1 
ATOM   4515 C CG  . ARG B 2 314 ? 171.336 183.423 178.210 1.00 44.23  ? 314 ARG C CG  1 
ATOM   4516 C CD  . ARG B 2 314 ? 170.106 184.255 178.534 1.00 44.23  ? 314 ARG C CD  1 
ATOM   4517 N NE  . ARG B 2 314 ? 170.162 185.579 177.927 1.00 44.23  ? 314 ARG C NE  1 
ATOM   4518 C CZ  . ARG B 2 314 ? 169.413 186.606 178.302 1.00 44.23  ? 314 ARG C CZ  1 
ATOM   4519 N NH1 . ARG B 2 314 ? 168.564 186.511 179.312 1.00 44.23  ? 314 ARG C NH1 1 
ATOM   4520 N NH2 . ARG B 2 314 ? 169.521 187.760 177.650 1.00 44.23  ? 314 ARG C NH2 1 
ATOM   4521 N N   . VAL B 2 315 ? 172.861 180.500 178.532 1.00 42.87  ? 315 VAL C N   1 
ATOM   4522 C CA  . VAL B 2 315 ? 172.732 179.617 179.685 1.00 42.87  ? 315 VAL C CA  1 
ATOM   4523 C C   . VAL B 2 315 ? 171.862 180.276 180.749 1.00 42.87  ? 315 VAL C C   1 
ATOM   4524 O O   . VAL B 2 315 ? 171.705 181.503 180.791 1.00 42.87  ? 315 VAL C O   1 
ATOM   4525 C CB  . VAL B 2 315 ? 174.109 179.230 180.256 1.00 42.87  ? 315 VAL C CB  1 
ATOM   4526 C CG1 . VAL B 2 315 ? 175.020 178.730 179.150 1.00 42.87  ? 315 VAL C CG1 1 
ATOM   4527 C CG2 . VAL B 2 315 ? 174.735 180.389 180.995 1.00 42.87  ? 315 VAL C CG2 1 
ATOM   4528 N N   . SER B 2 316 ? 171.271 179.452 181.609 1.00 42.60  ? 316 SER C N   1 
ATOM   4529 C CA  . SER B 2 316 ? 170.411 179.952 182.669 1.00 42.60  ? 316 SER C CA  1 
ATOM   4530 C C   . SER B 2 316 ? 170.667 179.315 184.025 1.00 42.60  ? 316 SER C C   1 
ATOM   4531 O O   . SER B 2 316 ? 170.187 179.851 185.030 1.00 42.60  ? 316 SER C O   1 
ATOM   4532 C CB  . SER B 2 316 ? 168.935 179.752 182.303 1.00 42.60  ? 316 SER C CB  1 
ATOM   4533 O OG  . SER B 2 316 ? 168.668 178.390 182.026 1.00 42.60  ? 316 SER C OG  1 
ATOM   4534 N N   . CYS B 2 317 ? 171.406 178.210 184.092 1.00 42.47  ? 317 CYS C N   1 
ATOM   4535 C CA  . CYS B 2 317 ? 171.619 177.501 185.344 1.00 42.47  ? 317 CYS C CA  1 
ATOM   4536 C C   . CYS B 2 317 ? 172.828 176.589 185.213 1.00 42.47  ? 317 CYS C C   1 
ATOM   4537 O O   . CYS B 2 317 ? 173.014 175.943 184.181 1.00 42.47  ? 317 CYS C O   1 
ATOM   4538 C CB  . CYS B 2 317 ? 170.376 176.697 185.733 1.00 42.47  ? 317 CYS C CB  1 
ATOM   4539 S SG  . CYS B 2 317 ? 169.748 175.638 184.410 1.00 42.47  ? 317 CYS C SG  1 
ATOM   4540 N N   . LEU B 2 318 ? 173.642 176.544 186.266 1.00 38.13  ? 318 LEU C N   1 
ATOM   4541 C CA  . LEU B 2 318 ? 174.774 175.631 186.327 1.00 38.13  ? 318 LEU C CA  1 
ATOM   4542 C C   . LEU B 2 318 ? 175.012 175.247 187.779 1.00 38.13  ? 318 LEU C C   1 
ATOM   4543 O O   . LEU B 2 318 ? 174.873 176.080 188.677 1.00 38.13  ? 318 LEU C O   1 
ATOM   4544 C CB  . LEU B 2 318 ? 176.029 176.255 185.699 1.00 38.13  ? 318 LEU C CB  1 
ATOM   4545 C CG  . LEU B 2 318 ? 176.700 177.524 186.233 1.00 38.13  ? 318 LEU C CG  1 
ATOM   4546 C CD1 . LEU B 2 318 ? 177.722 177.257 187.333 1.00 38.13  ? 318 LEU C CD1 1 
ATOM   4547 C CD2 . LEU B 2 318 ? 177.336 178.285 185.089 1.00 38.13  ? 318 LEU C CD2 1 
ATOM   4548 N N   . GLY B 2 319 ? 175.366 173.990 188.001 1.00 41.50  ? 319 GLY C N   1 
ATOM   4549 C CA  . GLY B 2 319 ? 175.614 173.506 189.345 1.00 41.50  ? 319 GLY C CA  1 
ATOM   4550 C C   . GLY B 2 319 ? 176.725 172.482 189.363 1.00 41.50  ? 319 GLY C C   1 
ATOM   4551 O O   . GLY B 2 319 ? 176.676 171.464 188.670 1.00 41.50  ? 319 GLY C O   1 
ATOM   4552 N N   . VAL B 2 320 ? 177.732 172.761 190.181 1.00 44.99  ? 320 VAL C N   1 
ATOM   4553 C CA  . VAL B 2 320 ? 178.819 171.827 190.445 1.00 44.99  ? 320 VAL C CA  1 
ATOM   4554 C C   . VAL B 2 320 ? 178.376 170.916 191.580 1.00 44.99  ? 320 VAL C C   1 
ATOM   4555 O O   . VAL B 2 320 ? 177.732 171.367 192.536 1.00 44.99  ? 320 VAL C O   1 
ATOM   4556 C CB  . VAL B 2 320 ? 180.122 172.573 190.792 1.00 44.99  ? 320 VAL C CB  1 
ATOM   4557 C CG1 . VAL B 2 320 ? 181.285 171.611 190.900 1.00 44.99  ? 320 VAL C CG1 1 
ATOM   4558 C CG2 . VAL B 2 320 ? 180.415 173.635 189.755 1.00 44.99  ? 320 VAL C CG2 1 
ATOM   4559 N N   . THR B 2 321 ? 178.697 169.629 191.465 1.00 50.23  ? 321 THR C N   1 
ATOM   4560 C CA  . THR B 2 321 ? 178.246 168.649 192.442 1.00 50.23  ? 321 THR C CA  1 
ATOM   4561 C C   . THR B 2 321 ? 178.942 168.857 193.781 1.00 50.23  ? 321 THR C C   1 
ATOM   4562 O O   . THR B 2 321 ? 179.990 169.502 193.870 1.00 50.23  ? 321 THR C O   1 
ATOM   4563 C CB  . THR B 2 321 ? 178.513 167.238 191.933 1.00 50.23  ? 321 THR C CB  1 
ATOM   4564 O OG1 . THR B 2 321 ? 179.852 167.166 191.435 1.00 50.23  ? 321 THR C OG1 1 
ATOM   4565 C CG2 . THR B 2 321 ? 177.552 166.887 190.817 1.00 50.23  ? 321 THR C CG2 1 
ATOM   4566 N N   . ASP B 2 322 ? 178.337 168.303 194.836 1.00 58.64  ? 322 ASP C N   1 
ATOM   4567 C CA  . ASP B 2 322 ? 178.851 168.477 196.191 1.00 58.64  ? 322 ASP C CA  1 
ATOM   4568 C C   . ASP B 2 322 ? 180.189 167.787 196.418 1.00 58.64  ? 322 ASP C C   1 
ATOM   4569 O O   . ASP B 2 322 ? 180.920 168.188 197.330 1.00 58.64  ? 322 ASP C O   1 
ATOM   4570 C CB  . ASP B 2 322 ? 177.832 167.968 197.212 1.00 58.64  ? 322 ASP C CB  1 
ATOM   4571 C CG  . ASP B 2 322 ? 176.659 168.913 197.386 1.00 58.64  ? 322 ASP C CG  1 
ATOM   4572 O OD1 . ASP B 2 322 ? 176.832 170.126 197.144 1.00 58.64  ? 322 ASP C OD1 1 
ATOM   4573 O OD2 . ASP B 2 322 ? 175.569 168.447 197.776 1.00 58.64  ? 322 ASP C OD2 1 
ATOM   4574 N N   . ASP B 2 323 ? 180.531 166.775 195.624 1.00 56.80  ? 323 ASP C N   1 
ATOM   4575 C CA  . ASP B 2 323 ? 181.849 166.161 195.685 1.00 56.80  ? 323 ASP C CA  1 
ATOM   4576 C C   . ASP B 2 323 ? 182.811 166.765 194.673 1.00 56.80  ? 323 ASP C C   1 
ATOM   4577 O O   . ASP B 2 323 ? 183.884 166.201 194.440 1.00 56.80  ? 323 ASP C O   1 
ATOM   4578 C CB  . ASP B 2 323 ? 181.750 164.647 195.479 1.00 56.80  ? 323 ASP C CB  1 
ATOM   4579 C CG  . ASP B 2 323 ? 180.939 164.276 194.260 1.00 56.80  ? 323 ASP C CG  1 
ATOM   4580 O OD1 . ASP B 2 323 ? 180.272 165.163 193.698 1.00 56.80  ? 323 ASP C OD1 1 
ATOM   4581 O OD2 . ASP B 2 323 ? 180.970 163.094 193.860 1.00 56.80  ? 323 ASP C OD2 1 
ATOM   4582 N N   . GLY B 2 324 ? 182.453 167.900 194.073 1.00 52.06  ? 324 GLY C N   1 
ATOM   4583 C CA  . GLY B 2 324 ? 183.327 168.558 193.124 1.00 52.06  ? 324 GLY C CA  1 
ATOM   4584 C C   . GLY B 2 324 ? 183.514 167.813 191.827 1.00 52.06  ? 324 GLY C C   1 
ATOM   4585 O O   . GLY B 2 324 ? 184.487 168.064 191.114 1.00 52.06  ? 324 GLY C O   1 
ATOM   4586 N N   . MET B 2 325 ? 182.590 166.912 191.490 1.00 52.86  ? 325 MET C N   1 
ATOM   4587 C CA  . MET B 2 325 ? 182.816 165.995 190.378 1.00 52.86  ? 325 MET C CA  1 
ATOM   4588 C C   . MET B 2 325 ? 182.626 166.683 189.031 1.00 52.86  ? 325 MET C C   1 
ATOM   4589 O O   . MET B 2 325 ? 183.563 166.759 188.228 1.00 52.86  ? 325 MET C O   1 
ATOM   4590 C CB  . MET B 2 325 ? 181.894 164.783 190.508 1.00 52.86  ? 325 MET C CB  1 
ATOM   4591 C CG  . MET B 2 325 ? 182.091 163.769 189.414 1.00 52.86  ? 325 MET C CG  1 
ATOM   4592 S SD  . MET B 2 325 ? 183.772 163.137 189.386 1.00 52.86  ? 325 MET C SD  1 
ATOM   4593 C CE  . MET B 2 325 ? 183.967 162.907 187.625 1.00 52.86  ? 325 MET C CE  1 
ATOM   4594 N N   . ALA B 2 326 ? 181.426 167.194 188.760 1.00 46.11  ? 326 ALA C N   1 
ATOM   4595 C CA  . ALA B 2 326 ? 181.159 167.763 187.447 1.00 46.11  ? 326 ALA C CA  1 
ATOM   4596 C C   . ALA B 2 326 ? 180.080 168.829 187.546 1.00 46.11  ? 326 ALA C C   1 
ATOM   4597 O O   . ALA B 2 326 ? 179.269 168.840 188.475 1.00 46.11  ? 326 ALA C O   1 
ATOM   4598 C CB  . ALA B 2 326 ? 180.743 166.685 186.444 1.00 46.11  ? 326 ALA C CB  1 
ATOM   4599 N N   . VAL B 2 327 ? 180.076 169.713 186.551 1.00 41.18  ? 327 VAL C N   1 
ATOM   4600 C CA  . VAL B 2 327 ? 179.153 170.839 186.468 1.00 41.18  ? 327 VAL C CA  1 
ATOM   4601 C C   . VAL B 2 327 ? 178.165 170.576 185.339 1.00 41.18  ? 327 VAL C C   1 
ATOM   4602 O O   . VAL B 2 327 ? 178.541 170.085 184.269 1.00 41.18  ? 327 VAL C O   1 
ATOM   4603 C CB  . VAL B 2 327 ? 179.915 172.170 186.273 1.00 41.18  ? 327 VAL C CB  1 
ATOM   4604 C CG1 . VAL B 2 327 ? 180.820 172.136 185.046 1.00 41.18  ? 327 VAL C CG1 1 
ATOM   4605 C CG2 . VAL B 2 327 ? 178.952 173.343 186.190 1.00 41.18  ? 327 VAL C CG2 1 
ATOM   4606 N N   . ALA B 2 328 ? 176.891 170.856 185.595 1.00 39.02  ? 328 ALA C N   1 
ATOM   4607 C CA  . ALA B 2 328 ? 175.831 170.675 184.608 1.00 39.02  ? 328 ALA C CA  1 
ATOM   4608 C C   . ALA B 2 328 ? 175.251 172.045 184.275 1.00 39.02  ? 328 ALA C C   1 
ATOM   4609 O O   . ALA B 2 328 ? 174.433 172.578 185.030 1.00 39.02  ? 328 ALA C O   1 
ATOM   4610 C CB  . ALA B 2 328 ? 174.759 169.724 185.126 1.00 39.02  ? 328 ALA C CB  1 
ATOM   4611 N N   . THR B 2 329 ? 175.668 172.607 183.142 1.00 37.19  ? 329 THR C N   1 
ATOM   4612 C CA  . THR B 2 329 ? 175.229 173.933 182.720 1.00 37.19  ? 329 THR C CA  1 
ATOM   4613 C C   . THR B 2 329 ? 173.976 173.793 181.864 1.00 37.19  ? 329 THR C C   1 
ATOM   4614 O O   . THR B 2 329 ? 174.038 173.289 180.739 1.00 37.19  ? 329 THR C O   1 
ATOM   4615 C CB  . THR B 2 329 ? 176.331 174.653 181.946 1.00 37.19  ? 329 THR C CB  1 
ATOM   4616 O OG1 . THR B 2 329 ? 176.459 174.071 180.646 1.00 37.19  ? 329 THR C OG1 1 
ATOM   4617 C CG2 . THR B 2 329 ? 177.656 174.536 182.669 1.00 37.19  ? 329 THR C CG2 1 
ATOM   4618 N N   . GLY B 2 330 ? 172.838 174.234 182.396 1.00 40.80  ? 330 GLY C N   1 
ATOM   4619 C CA  . GLY B 2 330 ? 171.628 174.299 181.609 1.00 40.80  ? 330 GLY C CA  1 
ATOM   4620 C C   . GLY B 2 330 ? 171.547 175.579 180.813 1.00 40.80  ? 330 GLY C C   1 
ATOM   4621 O O   . GLY B 2 330 ? 172.215 176.569 181.105 1.00 40.80  ? 330 GLY C O   1 
ATOM   4622 N N   . SER B 2 331 ? 170.708 175.561 179.784 1.00 46.99  ? 331 SER C N   1 
ATOM   4623 C CA  . SER B 2 331 ? 170.621 176.701 178.884 1.00 46.99  ? 331 SER C CA  1 
ATOM   4624 C C   . SER B 2 331 ? 169.230 176.751 178.271 1.00 46.99  ? 331 SER C C   1 
ATOM   4625 O O   . SER B 2 331 ? 168.373 175.908 178.546 1.00 46.99  ? 331 SER C O   1 
ATOM   4626 C CB  . SER B 2 331 ? 171.699 176.635 177.803 1.00 46.99  ? 331 SER C CB  1 
ATOM   4627 O OG  . SER B 2 331 ? 171.329 177.416 176.681 1.00 46.99  ? 331 SER C OG  1 
ATOM   4628 N N   . TRP B 2 332 ? 169.018 177.759 177.426 1.00 47.38  ? 332 TRP C N   1 
ATOM   4629 C CA  . TRP B 2 332 ? 167.719 178.015 176.822 1.00 47.38  ? 332 TRP C CA  1 
ATOM   4630 C C   . TRP B 2 332 ? 167.439 177.144 175.607 1.00 47.38  ? 332 TRP C C   1 
ATOM   4631 O O   . TRP B 2 332 ? 166.301 177.131 175.126 1.00 47.38  ? 332 TRP C O   1 
ATOM   4632 C CB  . TRP B 2 332 ? 167.615 179.485 176.417 1.00 47.38  ? 332 TRP C CB  1 
ATOM   4633 C CG  . TRP B 2 332 ? 167.388 180.410 177.561 1.00 47.38  ? 332 TRP C CG  1 
ATOM   4634 C CD1 . TRP B 2 332 ? 167.448 180.104 178.887 1.00 47.38  ? 332 TRP C CD1 1 
ATOM   4635 C CD2 . TRP B 2 332 ? 167.057 181.798 177.484 1.00 47.38  ? 332 TRP C CD2 1 
ATOM   4636 N NE1 . TRP B 2 332 ? 167.176 181.217 179.642 1.00 47.38  ? 332 TRP C NE1 1 
ATOM   4637 C CE2 . TRP B 2 332 ? 166.932 182.271 178.803 1.00 47.38  ? 332 TRP C CE2 1 
ATOM   4638 C CE3 . TRP B 2 332 ? 166.855 182.687 176.426 1.00 47.38  ? 332 TRP C CE3 1 
ATOM   4639 C CZ2 . TRP B 2 332 ? 166.614 183.594 179.092 1.00 47.38  ? 332 TRP C CZ2 1 
ATOM   4640 C CZ3 . TRP B 2 332 ? 166.539 183.999 176.715 1.00 47.38  ? 332 TRP C CZ3 1 
ATOM   4641 C CH2 . TRP B 2 332 ? 166.421 184.440 178.037 1.00 47.38  ? 332 TRP C CH2 1 
ATOM   4642 N N   . ASP B 2 333 ? 168.437 176.422 175.103 1.00 42.53  ? 333 ASP C N   1 
ATOM   4643 C CA  . ASP B 2 333 ? 168.297 175.617 173.900 1.00 42.53  ? 333 ASP C CA  1 
ATOM   4644 C C   . ASP B 2 333 ? 167.866 174.186 174.191 1.00 42.53  ? 333 ASP C C   1 
ATOM   4645 O O   . ASP B 2 333 ? 168.155 173.293 173.387 1.00 42.53  ? 333 ASP C O   1 
ATOM   4646 C CB  . ASP B 2 333 ? 169.609 175.628 173.116 1.00 42.53  ? 333 ASP C CB  1 
ATOM   4647 C CG  . ASP B 2 333 ? 170.809 175.375 173.998 1.00 42.53  ? 333 ASP C CG  1 
ATOM   4648 O OD1 . ASP B 2 333 ? 170.611 175.077 175.192 1.00 42.53  ? 333 ASP C OD1 1 
ATOM   4649 O OD2 . ASP B 2 333 ? 171.950 175.476 173.507 1.00 42.53  ? 333 ASP C OD2 1 
ATOM   4650 N N   . SER B 2 334 ? 167.199 173.957 175.328 1.00 44.64  ? 334 SER C N   1 
ATOM   4651 C CA  . SER B 2 334 ? 166.709 172.643 175.757 1.00 44.64  ? 334 SER C CA  1 
ATOM   4652 C C   . SER B 2 334 ? 167.837 171.625 175.898 1.00 44.64  ? 334 SER C C   1 
ATOM   4653 O O   . SER B 2 334 ? 167.628 170.424 175.715 1.00 44.64  ? 334 SER C O   1 
ATOM   4654 C CB  . SER B 2 334 ? 165.623 172.107 174.818 1.00 44.64  ? 334 SER C CB  1 
ATOM   4655 O OG  . SER B 2 334 ? 166.191 171.594 173.626 1.00 44.64  ? 334 SER C OG  1 
ATOM   4656 N N   . PHE B 2 335 ? 169.036 172.093 176.228 1.00 45.01  ? 335 PHE C N   1 
ATOM   4657 C CA  . PHE B 2 335 ? 170.176 171.226 176.466 1.00 45.01  ? 335 PHE C CA  1 
ATOM   4658 C C   . PHE B 2 335 ? 170.616 171.344 177.916 1.00 45.01  ? 335 PHE C C   1 
ATOM   4659 O O   . PHE B 2 335 ? 170.273 172.297 178.620 1.00 45.01  ? 335 PHE C O   1 
ATOM   4660 C CB  . PHE B 2 335 ? 171.360 171.565 175.549 1.00 45.01  ? 335 PHE C CB  1 
ATOM   4661 C CG  . PHE B 2 335 ? 171.149 171.181 174.115 1.00 45.01  ? 335 PHE C CG  1 
ATOM   4662 C CD1 . PHE B 2 335 ? 170.227 170.203 173.773 1.00 45.01  ? 335 PHE C CD1 1 
ATOM   4663 C CD2 . PHE B 2 335 ? 171.893 171.781 173.111 1.00 45.01  ? 335 PHE C CD2 1 
ATOM   4664 C CE1 . PHE B 2 335 ? 170.034 169.845 172.453 1.00 45.01  ? 335 PHE C CE1 1 
ATOM   4665 C CE2 . PHE B 2 335 ? 171.708 171.427 171.789 1.00 45.01  ? 335 PHE C CE2 1 
ATOM   4666 C CZ  . PHE B 2 335 ? 170.776 170.457 171.459 1.00 45.01  ? 335 PHE C CZ  1 
ATOM   4667 N N   . LEU B 2 336 ? 171.381 170.350 178.358 1.00 40.62  ? 336 LEU C N   1 
ATOM   4668 C CA  . LEU B 2 336 ? 171.989 170.383 179.684 1.00 40.62  ? 336 LEU C CA  1 
ATOM   4669 C C   . LEU B 2 336 ? 173.302 169.613 179.578 1.00 40.62  ? 336 LEU C C   1 
ATOM   4670 O O   . LEU B 2 336 ? 173.318 168.384 179.691 1.00 40.62  ? 336 LEU C O   1 
ATOM   4671 C CB  . LEU B 2 336 ? 171.049 169.798 180.731 1.00 40.62  ? 336 LEU C CB  1 
ATOM   4672 C CG  . LEU B 2 336 ? 171.550 169.594 182.157 1.00 40.62  ? 336 LEU C CG  1 
ATOM   4673 C CD1 . LEU B 2 336 ? 172.160 170.861 182.696 1.00 40.62  ? 336 LEU C CD1 1 
ATOM   4674 C CD2 . LEU B 2 336 ? 170.386 169.187 183.026 1.00 40.62  ? 336 LEU C CD2 1 
ATOM   4675 N N   . LYS B 2 337 ? 174.389 170.341 179.342 1.00 37.21  ? 337 LYS C N   1 
ATOM   4676 C CA  . LYS B 2 337 ? 175.689 169.733 179.113 1.00 37.21  ? 337 LYS C CA  1 
ATOM   4677 C C   . LYS B 2 337 ? 176.448 169.582 180.421 1.00 37.21  ? 337 LYS C C   1 
ATOM   4678 O O   . LYS B 2 337 ? 176.454 170.486 181.261 1.00 37.21  ? 337 LYS C O   1 
ATOM   4679 C CB  . LYS B 2 337 ? 176.509 170.561 178.125 1.00 37.21  ? 337 LYS C CB  1 
ATOM   4680 C CG  . LYS B 2 337 ? 176.002 170.472 176.697 1.00 37.21  ? 337 LYS C CG  1 
ATOM   4681 C CD  . LYS B 2 337 ? 176.939 171.156 175.717 1.00 37.21  ? 337 LYS C CD  1 
ATOM   4682 C CE  . LYS B 2 337 ? 176.378 171.102 174.308 1.00 37.21  ? 337 LYS C CE  1 
ATOM   4683 N NZ  . LYS B 2 337 ? 176.293 169.707 173.811 1.00 37.21  ? 337 LYS C NZ  1 
ATOM   4684 N N   . ILE B 2 338 ? 177.090 168.430 180.586 1.00 38.98  ? 338 ILE C N   1 
ATOM   4685 C CA  . ILE B 2 338 ? 177.858 168.102 181.779 1.00 38.98  ? 338 ILE C CA  1 
ATOM   4686 C C   . ILE B 2 338 ? 179.330 168.099 181.400 1.00 38.98  ? 338 ILE C C   1 
ATOM   4687 O O   . ILE B 2 338 ? 179.726 167.442 180.431 1.00 38.98  ? 338 ILE C O   1 
ATOM   4688 C CB  . ILE B 2 338 ? 177.426 166.750 182.369 1.00 38.98  ? 338 ILE C CB  1 
ATOM   4689 C CG1 . ILE B 2 338 ? 175.989 166.843 182.883 1.00 38.98  ? 338 ILE C CG1 1 
ATOM   4690 C CG2 . ILE B 2 338 ? 178.365 166.327 183.482 1.00 38.98  ? 338 ILE C CG2 1 
ATOM   4691 C CD1 . ILE B 2 338 ? 175.459 165.558 183.463 1.00 38.98  ? 338 ILE C CD1 1 
ATOM   4692 N N   . TRP B 2 339 ? 180.135 168.829 182.161 1.00 40.28  ? 339 TRP C N   1 
ATOM   4693 C CA  . TRP B 2 339 ? 181.511 169.131 181.802 1.00 40.28  ? 339 TRP C CA  1 
ATOM   4694 C C   . TRP B 2 339 ? 182.450 168.587 182.866 1.00 40.28  ? 339 TRP C C   1 
ATOM   4695 O O   . TRP B 2 339 ? 182.098 168.533 184.047 1.00 40.28  ? 339 TRP C O   1 
ATOM   4696 C CB  . TRP B 2 339 ? 181.717 170.643 181.636 1.00 40.28  ? 339 TRP C CB  1 
ATOM   4697 C CG  . TRP B 2 339 ? 180.692 171.320 180.766 1.00 40.28  ? 339 TRP C CG  1 
ATOM   4698 C CD1 . TRP B 2 339 ? 179.383 171.565 181.069 1.00 40.28  ? 339 TRP C CD1 1 
ATOM   4699 C CD2 . TRP B 2 339 ? 180.910 171.886 179.471 1.00 40.28  ? 339 TRP C CD2 1 
ATOM   4700 N NE1 . TRP B 2 339 ? 178.767 172.213 180.031 1.00 40.28  ? 339 TRP C NE1 1 
ATOM   4701 C CE2 . TRP B 2 339 ? 179.684 172.426 179.038 1.00 40.28  ? 339 TRP C CE2 1 
ATOM   4702 C CE3 . TRP B 2 339 ? 182.018 171.975 178.629 1.00 40.28  ? 339 TRP C CE3 1 
ATOM   4703 C CZ2 . TRP B 2 339 ? 179.539 173.048 177.804 1.00 40.28  ? 339 TRP C CZ2 1 
ATOM   4704 C CZ3 . TRP B 2 339 ? 181.871 172.591 177.404 1.00 40.28  ? 339 TRP C CZ3 1 
ATOM   4705 C CH2 . TRP B 2 339 ? 180.641 173.120 177.003 1.00 40.28  ? 339 TRP C CH2 1 
ATOM   4706 N N   . ASN B 2 340 ? 183.641 168.181 182.445 1.00 45.92  ? 340 ASN C N   1 
ATOM   4707 C CA  . ASN B 2 340 ? 184.604 167.572 183.354 1.00 45.92  ? 340 ASN C CA  1 
ATOM   4708 C C   . ASN B 2 340 ? 186.032 167.887 182.926 1.00 45.92  ? 340 ASN C C   1 
ATOM   4709 O O   . ASN B 2 340 ? 186.917 168.096 183.754 1.00 45.92  ? 340 ASN C O   1 
ATOM   4710 C CB  . ASN B 2 340 ? 184.394 166.059 183.410 1.00 45.92  ? 340 ASN C CB  1 
ATOM   4711 C CG  . ASN B 2 340 ? 185.103 165.410 184.581 1.00 45.92  ? 340 ASN C CG  1 
ATOM   4712 O OD1 . ASN B 2 340 ? 185.703 166.085 185.417 1.00 45.92  ? 340 ASN C OD1 1 
ATOM   4713 N ND2 . ASN B 2 340 ? 185.045 164.085 184.641 1.00 45.92  ? 340 ASN C ND2 1 
ATOM   4714 O OXT . ASN B 2 340 ? 186.336 167.934 181.736 1.00 45.92  ? 340 ASN C OXT 1 
ATOM   4715 N N   . SER C 3 8   ? 156.110 205.165 205.093 1.00 209.51 ? 8   SER D N   1 
ATOM   4716 C CA  . SER C 3 8   ? 155.690 206.148 206.084 1.00 209.51 ? 8   SER D CA  1 
ATOM   4717 C C   . SER C 3 8   ? 156.758 206.331 207.156 1.00 209.51 ? 8   SER D C   1 
ATOM   4718 O O   . SER C 3 8   ? 157.909 205.938 206.971 1.00 209.51 ? 8   SER D O   1 
ATOM   4719 C CB  . SER C 3 8   ? 154.366 205.731 206.726 1.00 209.51 ? 8   SER D CB  1 
ATOM   4720 O OG  . SER C 3 8   ? 153.981 206.642 207.741 1.00 209.51 ? 8   SER D OG  1 
ATOM   4721 N N   . ILE C 3 9   ? 156.366 206.940 208.278 1.00 206.54 ? 9   ILE D N   1 
ATOM   4722 C CA  . ILE C 3 9   ? 157.305 207.149 209.375 1.00 206.54 ? 9   ILE D CA  1 
ATOM   4723 C C   . ILE C 3 9   ? 157.643 205.827 210.060 1.00 206.54 ? 9   ILE D C   1 
ATOM   4724 O O   . ILE C 3 9   ? 158.767 205.643 210.550 1.00 206.54 ? 9   ILE D O   1 
ATOM   4725 C CB  . ILE C 3 9   ? 156.743 208.205 210.354 1.00 206.54 ? 9   ILE D CB  1 
ATOM   4726 C CG1 . ILE C 3 9   ? 157.782 208.587 211.413 1.00 206.54 ? 9   ILE D CG1 1 
ATOM   4727 C CG2 . ILE C 3 9   ? 155.424 207.755 210.985 1.00 206.54 ? 9   ILE D CG2 1 
ATOM   4728 C CD1 . ILE C 3 9   ? 157.412 209.820 212.206 1.00 206.54 ? 9   ILE D CD1 1 
ATOM   4729 N N   . ALA C 3 10  ? 156.699 204.879 210.087 1.00 203.34 ? 10  ALA D N   1 
ATOM   4730 C CA  . ALA C 3 10  ? 156.969 203.569 210.673 1.00 203.34 ? 10  ALA D CA  1 
ATOM   4731 C C   . ALA C 3 10  ? 157.989 202.795 209.849 1.00 203.34 ? 10  ALA D C   1 
ATOM   4732 O O   . ALA C 3 10  ? 158.838 202.088 210.407 1.00 203.34 ? 10  ALA D O   1 
ATOM   4733 C CB  . ALA C 3 10  ? 155.670 202.775 210.805 1.00 203.34 ? 10  ALA D CB  1 
ATOM   4734 N N   . GLN C 3 11  ? 157.924 202.923 208.520 1.00 198.41 ? 11  GLN D N   1 
ATOM   4735 C CA  . GLN C 3 11  ? 158.924 202.300 207.660 1.00 198.41 ? 11  GLN D CA  1 
ATOM   4736 C C   . GLN C 3 11  ? 160.304 202.896 207.901 1.00 198.41 ? 11  GLN D C   1 
ATOM   4737 O O   . GLN C 3 11  ? 161.305 202.171 207.926 1.00 198.41 ? 11  GLN D O   1 
ATOM   4738 C CB  . GLN C 3 11  ? 158.524 202.453 206.193 1.00 198.41 ? 11  GLN D CB  1 
ATOM   4739 N N   . ALA C 3 12  ? 160.375 204.218 208.085 1.00 193.67 ? 12  ALA D N   1 
ATOM   4740 C CA  . ALA C 3 12  ? 161.650 204.863 208.383 1.00 193.67 ? 12  ALA D CA  1 
ATOM   4741 C C   . ALA C 3 12  ? 162.201 204.407 209.726 1.00 193.67 ? 12  ALA D C   1 
ATOM   4742 O O   . ALA C 3 12  ? 163.410 204.184 209.863 1.00 193.67 ? 12  ALA D O   1 
ATOM   4743 C CB  . ALA C 3 12  ? 161.489 206.381 208.359 1.00 193.67 ? 12  ALA D CB  1 
ATOM   4744 N N   . ARG C 3 13  ? 161.328 204.264 210.729 1.00 195.97 ? 13  ARG D N   1 
ATOM   4745 C CA  . ARG C 3 13  ? 161.756 203.755 212.030 1.00 195.97 ? 13  ARG D CA  1 
ATOM   4746 C C   . ARG C 3 13  ? 162.286 202.332 211.916 1.00 195.97 ? 13  ARG D C   1 
ATOM   4747 O O   . ARG C 3 13  ? 163.323 201.994 212.501 1.00 195.97 ? 13  ARG D O   1 
ATOM   4748 C CB  . ARG C 3 13  ? 160.596 203.808 213.025 1.00 195.97 ? 13  ARG D CB  1 
ATOM   4749 C CG  . ARG C 3 13  ? 160.209 205.200 213.481 1.00 195.97 ? 13  ARG D CG  1 
ATOM   4750 C CD  . ARG C 3 13  ? 159.326 205.142 214.719 1.00 195.97 ? 13  ARG D CD  1 
ATOM   4751 N NE  . ARG C 3 13  ? 158.051 204.483 214.460 1.00 195.97 ? 13  ARG D NE  1 
ATOM   4752 C CZ  . ARG C 3 13  ? 156.946 205.112 214.084 1.00 195.97 ? 13  ARG D CZ  1 
ATOM   4753 N NH1 . ARG C 3 13  ? 156.919 206.424 213.917 1.00 195.97 ? 13  ARG D NH1 1 
ATOM   4754 N NH2 . ARG C 3 13  ? 155.838 204.406 213.874 1.00 195.97 ? 13  ARG D NH2 1 
ATOM   4755 N N   . LYS C 3 14  ? 161.586 201.485 211.153 1.00 189.28 ? 14  LYS D N   1 
ATOM   4756 C CA  . LYS C 3 14  ? 162.022 200.105 210.971 1.00 189.28 ? 14  LYS D CA  1 
ATOM   4757 C C   . LYS C 3 14  ? 163.366 200.036 210.258 1.00 189.28 ? 14  LYS D C   1 
ATOM   4758 O O   . LYS C 3 14  ? 164.245 199.264 210.657 1.00 189.28 ? 14  LYS D O   1 
ATOM   4759 C CB  . LYS C 3 14  ? 160.965 199.317 210.198 1.00 189.28 ? 14  LYS D CB  1 
ATOM   4760 N N   . LEU C 3 15  ? 163.551 200.853 209.216 1.00 183.84 ? 15  LEU D N   1 
ATOM   4761 C CA  . LEU C 3 15  ? 164.818 200.854 208.490 1.00 183.84 ? 15  LEU D CA  1 
ATOM   4762 C C   . LEU C 3 15  ? 165.961 201.379 209.347 1.00 183.84 ? 15  LEU D C   1 
ATOM   4763 O O   . LEU C 3 15  ? 167.068 200.830 209.311 1.00 183.84 ? 15  LEU D O   1 
ATOM   4764 C CB  . LEU C 3 15  ? 164.704 201.675 207.206 1.00 183.84 ? 15  LEU D CB  1 
ATOM   4765 C CG  . LEU C 3 15  ? 163.799 201.122 206.107 1.00 183.84 ? 15  LEU D CG  1 
ATOM   4766 C CD1 . LEU C 3 15  ? 163.310 202.249 205.211 1.00 183.84 ? 15  LEU D CD1 1 
ATOM   4767 C CD2 . LEU C 3 15  ? 164.523 200.057 205.297 1.00 183.84 ? 15  LEU D CD2 1 
ATOM   4768 N N   . VAL C 3 16  ? 165.722 202.439 210.125 1.00 180.09 ? 16  VAL D N   1 
ATOM   4769 C CA  . VAL C 3 16  ? 166.813 202.997 210.918 1.00 180.09 ? 16  VAL D CA  1 
ATOM   4770 C C   . VAL C 3 16  ? 167.168 202.067 212.076 1.00 180.09 ? 16  VAL D C   1 
ATOM   4771 O O   . VAL C 3 16  ? 168.346 201.918 212.416 1.00 180.09 ? 16  VAL D O   1 
ATOM   4772 C CB  . VAL C 3 16  ? 166.492 204.438 211.374 1.00 180.09 ? 16  VAL D CB  1 
ATOM   4773 C CG1 . VAL C 3 16  ? 165.442 204.496 212.478 1.00 180.09 ? 16  VAL D CG1 1 
ATOM   4774 C CG2 . VAL C 3 16  ? 167.769 205.154 211.803 1.00 180.09 ? 16  VAL D CG2 1 
ATOM   4775 N N   . GLU C 3 17  ? 166.182 201.361 212.646 1.00 177.72 ? 17  GLU D N   1 
ATOM   4776 C CA  . GLU C 3 17  ? 166.504 200.376 213.674 1.00 177.72 ? 17  GLU D CA  1 
ATOM   4777 C C   . GLU C 3 17  ? 167.191 199.145 213.098 1.00 177.72 ? 17  GLU D C   1 
ATOM   4778 O O   . GLU C 3 17  ? 168.102 198.602 213.730 1.00 177.72 ? 17  GLU D O   1 
ATOM   4779 C CB  . GLU C 3 17  ? 165.246 199.957 214.436 1.00 177.72 ? 17  GLU D CB  1 
ATOM   4780 C CG  . GLU C 3 17  ? 164.655 201.042 215.317 1.00 177.72 ? 17  GLU D CG  1 
ATOM   4781 C CD  . GLU C 3 17  ? 165.559 201.411 216.472 1.00 177.72 ? 17  GLU D CD  1 
ATOM   4782 O OE1 . GLU C 3 17  ? 166.295 200.529 216.965 1.00 177.72 ? 17  GLU D OE1 1 
ATOM   4783 O OE2 . GLU C 3 17  ? 165.533 202.589 216.883 1.00 177.72 ? 17  GLU D OE2 1 
ATOM   4784 N N   . GLN C 3 18  ? 166.782 198.696 211.908 1.00 169.86 ? 18  GLN D N   1 
ATOM   4785 C CA  . GLN C 3 18  ? 167.432 197.554 211.276 1.00 169.86 ? 18  GLN D CA  1 
ATOM   4786 C C   . GLN C 3 18  ? 168.877 197.878 210.916 1.00 169.86 ? 18  GLN D C   1 
ATOM   4787 O O   . GLN C 3 18  ? 169.785 197.070 211.155 1.00 169.86 ? 18  GLN D O   1 
ATOM   4788 C CB  . GLN C 3 18  ? 166.632 197.149 210.038 1.00 169.86 ? 18  GLN D CB  1 
ATOM   4789 C CG  . GLN C 3 18  ? 167.114 195.920 209.298 1.00 169.86 ? 18  GLN D CG  1 
ATOM   4790 C CD  . GLN C 3 18  ? 167.470 194.774 210.216 1.00 169.86 ? 18  GLN D CD  1 
ATOM   4791 O OE1 . GLN C 3 18  ? 166.596 194.056 210.701 1.00 169.86 ? 18  GLN D OE1 1 
ATOM   4792 N NE2 . GLN C 3 18  ? 168.761 194.572 210.429 1.00 169.86 ? 18  GLN D NE2 1 
ATOM   4793 N N   . LEU C 3 19  ? 169.115 199.080 210.386 1.00 165.82 ? 19  LEU D N   1 
ATOM   4794 C CA  . LEU C 3 19  ? 170.473 199.500 210.063 1.00 165.82 ? 19  LEU D CA  1 
ATOM   4795 C C   . LEU C 3 19  ? 171.292 199.766 211.322 1.00 165.82 ? 19  LEU D C   1 
ATOM   4796 O O   . LEU C 3 19  ? 172.515 199.588 211.308 1.00 165.82 ? 19  LEU D O   1 
ATOM   4797 C CB  . LEU C 3 19  ? 170.421 200.728 209.148 1.00 165.82 ? 19  LEU D CB  1 
ATOM   4798 C CG  . LEU C 3 19  ? 171.662 201.327 208.479 1.00 165.82 ? 19  LEU D CG  1 
ATOM   4799 C CD1 . LEU C 3 19  ? 171.250 201.994 207.186 1.00 165.82 ? 19  LEU D CD1 1 
ATOM   4800 C CD2 . LEU C 3 19  ? 172.310 202.371 209.359 1.00 165.82 ? 19  LEU D CD2 1 
ATOM   4801 N N   . LYS C 3 20  ? 170.645 200.186 212.415 1.00 166.20 ? 20  LYS D N   1 
ATOM   4802 C CA  . LYS C 3 20  ? 171.349 200.325 213.686 1.00 166.20 ? 20  LYS D CA  1 
ATOM   4803 C C   . LYS C 3 20  ? 171.749 198.968 214.250 1.00 166.20 ? 20  LYS D C   1 
ATOM   4804 O O   . LYS C 3 20  ? 172.815 198.836 214.861 1.00 166.20 ? 20  LYS D O   1 
ATOM   4805 C CB  . LYS C 3 20  ? 170.483 201.088 214.688 1.00 166.20 ? 20  LYS D CB  1 
ATOM   4806 N N   . MET C 3 21  ? 170.889 197.959 214.081 1.00 167.74 ? 21  MET D N   1 
ATOM   4807 C CA  . MET C 3 21  ? 171.247 196.593 214.452 1.00 167.74 ? 21  MET D CA  1 
ATOM   4808 C C   . MET C 3 21  ? 172.416 196.084 213.620 1.00 167.74 ? 21  MET D C   1 
ATOM   4809 O O   . MET C 3 21  ? 173.309 195.406 214.141 1.00 167.74 ? 21  MET D O   1 
ATOM   4810 C CB  . MET C 3 21  ? 170.042 195.666 214.290 1.00 167.74 ? 21  MET D CB  1 
ATOM   4811 C CG  . MET C 3 21  ? 168.950 195.849 215.329 1.00 167.74 ? 21  MET D CG  1 
ATOM   4812 S SD  . MET C 3 21  ? 169.500 195.402 216.987 1.00 167.74 ? 21  MET D SD  1 
ATOM   4813 C CE  . MET C 3 21  ? 168.091 195.907 217.973 1.00 167.74 ? 21  MET D CE  1 
ATOM   4814 N N   . GLU C 3 22  ? 172.424 196.397 212.324 1.00 160.16 ? 22  GLU D N   1 
ATOM   4815 C CA  . GLU C 3 22  ? 173.544 195.994 211.481 1.00 160.16 ? 22  GLU D CA  1 
ATOM   4816 C C   . GLU C 3 22  ? 174.807 196.805 211.746 1.00 160.16 ? 22  GLU D C   1 
ATOM   4817 O O   . GLU C 3 22  ? 175.896 196.357 211.374 1.00 160.16 ? 22  GLU D O   1 
ATOM   4818 C CB  . GLU C 3 22  ? 173.166 196.118 210.012 1.00 160.16 ? 22  GLU D CB  1 
ATOM   4819 C CG  . GLU C 3 22  ? 171.999 195.264 209.634 1.00 160.16 ? 22  GLU D CG  1 
ATOM   4820 C CD  . GLU C 3 22  ? 171.548 195.538 208.233 1.00 160.16 ? 22  GLU D CD  1 
ATOM   4821 O OE1 . GLU C 3 22  ? 172.385 195.995 207.427 1.00 160.16 ? 22  GLU D OE1 1 
ATOM   4822 O OE2 . GLU C 3 22  ? 170.352 195.327 207.950 1.00 160.16 ? 22  GLU D OE2 1 
ATOM   4823 N N   . ALA C 3 23  ? 174.690 197.981 212.372 1.00 157.10 ? 23  ALA D N   1 
ATOM   4824 C CA  . ALA C 3 23  ? 175.867 198.804 212.650 1.00 157.10 ? 23  ALA D CA  1 
ATOM   4825 C C   . ALA C 3 23  ? 176.734 198.200 213.746 1.00 157.10 ? 23  ALA D C   1 
ATOM   4826 O O   . ALA C 3 23  ? 177.967 198.244 213.668 1.00 157.10 ? 23  ALA D O   1 
ATOM   4827 C CB  . ALA C 3 23  ? 175.438 200.214 213.051 1.00 157.10 ? 23  ALA D CB  1 
ATOM   4828 N N   . ASN C 3 24  ? 176.107 197.668 214.794 1.00 156.54 ? 24  ASN D N   1 
ATOM   4829 C CA  . ASN C 3 24  ? 176.819 197.217 215.987 1.00 156.54 ? 24  ASN D CA  1 
ATOM   4830 C C   . ASN C 3 24  ? 177.058 195.716 215.902 1.00 156.54 ? 24  ASN D C   1 
ATOM   4831 O O   . ASN C 3 24  ? 176.608 194.923 216.731 1.00 156.54 ? 24  ASN D O   1 
ATOM   4832 C CB  . ASN C 3 24  ? 176.053 197.613 217.237 1.00 156.54 ? 24  ASN D CB  1 
ATOM   4833 C CG  . ASN C 3 24  ? 176.101 199.090 217.471 1.00 156.54 ? 24  ASN D CG  1 
ATOM   4834 O OD1 . ASN C 3 24  ? 177.143 199.722 217.282 1.00 156.54 ? 24  ASN D OD1 1 
ATOM   4835 N ND2 . ASN C 3 24  ? 174.974 199.663 217.854 1.00 156.54 ? 24  ASN D ND2 1 
ATOM   4836 N N   . ILE C 3 25  ? 177.844 195.349 214.896 1.00 142.68 ? 25  ILE D N   1 
ATOM   4837 C CA  . ILE C 3 25  ? 178.327 193.995 214.680 1.00 142.68 ? 25  ILE D CA  1 
ATOM   4838 C C   . ILE C 3 25  ? 179.851 194.041 214.614 1.00 142.68 ? 25  ILE D C   1 
ATOM   4839 O O   . ILE C 3 25  ? 180.454 195.072 214.301 1.00 142.68 ? 25  ILE D O   1 
ATOM   4840 C CB  . ILE C 3 25  ? 177.709 193.368 213.397 1.00 142.68 ? 25  ILE D CB  1 
ATOM   4841 C CG1 . ILE C 3 25  ? 177.787 191.825 213.441 1.00 142.68 ? 25  ILE D CG1 1 
ATOM   4842 C CG2 . ILE C 3 25  ? 178.404 193.856 212.151 1.00 142.68 ? 25  ILE D CG2 1 
ATOM   4843 C CD1 . ILE C 3 25  ? 177.143 191.149 212.224 1.00 142.68 ? 25  ILE D CD1 1 
ATOM   4844 N N   . ASP C 3 26  ? 180.468 192.900 214.887 1.00 141.86 ? 26  ASP D N   1 
ATOM   4845 C CA  . ASP C 3 26  ? 181.913 192.789 214.933 1.00 141.86 ? 26  ASP D CA  1 
ATOM   4846 C C   . ASP C 3 26  ? 182.479 192.708 213.526 1.00 141.86 ? 26  ASP D C   1 
ATOM   4847 O O   . ASP C 3 26  ? 182.041 191.889 212.710 1.00 141.86 ? 26  ASP D O   1 
ATOM   4848 C CB  . ASP C 3 26  ? 182.320 191.565 215.748 1.00 141.86 ? 26  ASP D CB  1 
ATOM   4849 C CG  . ASP C 3 26  ? 183.795 191.560 216.088 1.00 141.86 ? 26  ASP D CG  1 
ATOM   4850 O OD1 . ASP C 3 26  ? 184.450 192.631 216.053 1.00 141.86 ? 26  ASP D OD1 1 
ATOM   4851 O OD2 . ASP C 3 26  ? 184.311 190.464 216.376 1.00 141.86 ? 26  ASP D OD2 1 
ATOM   4852 N N   . ARG C 3 27  ? 183.456 193.563 213.246 1.00 134.93 ? 27  ARG D N   1 
ATOM   4853 C CA  . ARG C 3 27  ? 184.143 193.577 211.960 1.00 134.93 ? 27  ARG D CA  1 
ATOM   4854 C C   . ARG C 3 27  ? 185.642 193.490 212.206 1.00 134.93 ? 27  ARG D C   1 
ATOM   4855 O O   . ARG C 3 27  ? 186.227 194.401 212.798 1.00 134.93 ? 27  ARG D O   1 
ATOM   4856 C CB  . ARG C 3 27  ? 183.803 194.839 211.172 1.00 134.93 ? 27  ARG D CB  1 
ATOM   4857 C CG  . ARG C 3 27  ? 182.333 194.960 210.822 1.00 134.93 ? 27  ARG D CG  1 
ATOM   4858 C CD  . ARG C 3 27  ? 182.144 195.608 209.460 1.00 134.93 ? 27  ARG D CD  1 
ATOM   4859 N NE  . ARG C 3 27  ? 180.790 195.433 208.949 1.00 134.93 ? 27  ARG D NE  1 
ATOM   4860 C CZ  . ARG C 3 27  ? 179.743 196.152 209.332 1.00 134.93 ? 27  ARG D CZ  1 
ATOM   4861 N NH1 . ARG C 3 27  ? 179.860 197.128 210.217 1.00 134.93 ? 27  ARG D NH1 1 
ATOM   4862 N NH2 . ARG C 3 27  ? 178.552 195.896 208.799 1.00 134.93 ? 27  ARG D NH2 1 
ATOM   4863 N N   . ILE C 3 28  ? 186.272 192.418 211.736 1.00 125.40 ? 28  ILE D N   1 
ATOM   4864 C CA  . ILE C 3 28  ? 187.713 192.251 211.865 1.00 125.40 ? 28  ILE D CA  1 
ATOM   4865 C C   . ILE C 3 28  ? 188.357 192.221 210.478 1.00 125.40 ? 28  ILE D C   1 
ATOM   4866 O O   . ILE C 3 28  ? 187.683 192.275 209.450 1.00 125.40 ? 28  ILE D O   1 
ATOM   4867 C CB  . ILE C 3 28  ? 188.084 191.004 212.690 1.00 125.40 ? 28  ILE D CB  1 
ATOM   4868 C CG1 . ILE C 3 28  ? 187.491 189.744 212.072 1.00 125.40 ? 28  ILE D CG1 1 
ATOM   4869 C CG2 . ILE C 3 28  ? 187.623 191.172 214.136 1.00 125.40 ? 28  ILE D CG2 1 
ATOM   4870 C CD1 . ILE C 3 28  ? 187.909 188.480 212.787 1.00 125.40 ? 28  ILE D CD1 1 
ATOM   4871 N N   . LYS C 3 29  ? 189.688 192.105 210.470 1.00 114.63 ? 29  LYS D N   1 
ATOM   4872 C CA  . LYS C 3 29  ? 190.500 192.496 209.322 1.00 114.63 ? 29  LYS D CA  1 
ATOM   4873 C C   . LYS C 3 29  ? 190.224 191.644 208.087 1.00 114.63 ? 29  LYS D C   1 
ATOM   4874 O O   . LYS C 3 29  ? 190.084 190.420 208.164 1.00 114.63 ? 29  LYS D O   1 
ATOM   4875 C CB  . LYS C 3 29  ? 191.982 192.420 209.690 1.00 114.63 ? 29  LYS D CB  1 
ATOM   4876 C CG  . LYS C 3 29  ? 192.394 193.393 210.784 1.00 114.63 ? 29  LYS D CG  1 
ATOM   4877 C CD  . LYS C 3 29  ? 192.336 194.830 210.293 1.00 114.63 ? 29  LYS D CD  1 
ATOM   4878 C CE  . LYS C 3 29  ? 192.756 195.800 211.386 1.00 114.63 ? 29  LYS D CE  1 
ATOM   4879 N NZ  . LYS C 3 29  ? 194.203 195.666 211.725 1.00 114.63 ? 29  LYS D NZ  1 
ATOM   4880 N N   . VAL C 3 30  ? 190.140 192.321 206.938 1.00 110.10 ? 30  VAL D N   1 
ATOM   4881 C CA  . VAL C 3 30  ? 189.869 191.678 205.658 1.00 110.10 ? 30  VAL D CA  1 
ATOM   4882 C C   . VAL C 3 30  ? 191.046 190.826 205.194 1.00 110.10 ? 30  VAL D C   1 
ATOM   4883 O O   . VAL C 3 30  ? 190.846 189.810 204.512 1.00 110.10 ? 30  VAL D O   1 
ATOM   4884 C CB  . VAL C 3 30  ? 189.501 192.776 204.638 1.00 110.10 ? 30  VAL D CB  1 
ATOM   4885 C CG1 . VAL C 3 30  ? 189.224 192.208 203.250 1.00 110.10 ? 30  VAL D CG1 1 
ATOM   4886 C CG2 . VAL C 3 30  ? 188.313 193.574 205.141 1.00 110.10 ? 30  VAL D CG2 1 
ATOM   4887 N N   . SER C 3 31  ? 192.274 191.211 205.561 1.00 107.81 ? 31  SER D N   1 
ATOM   4888 C CA  . SER C 3 31  ? 193.454 190.451 205.157 1.00 107.81 ? 31  SER D CA  1 
ATOM   4889 C C   . SER C 3 31  ? 193.434 189.041 205.730 1.00 107.81 ? 31  SER D C   1 
ATOM   4890 O O   . SER C 3 31  ? 193.861 188.090 205.067 1.00 107.81 ? 31  SER D O   1 
ATOM   4891 C CB  . SER C 3 31  ? 194.725 191.181 205.588 1.00 107.81 ? 31  SER D CB  1 
ATOM   4892 O OG  . SER C 3 31  ? 195.879 190.520 205.097 1.00 107.81 ? 31  SER D OG  1 
ATOM   4893 N N   . LYS C 3 32  ? 192.924 188.880 206.954 1.00 103.55 ? 32  LYS D N   1 
ATOM   4894 C CA  . LYS C 3 32  ? 192.806 187.540 207.517 1.00 103.55 ? 32  LYS D CA  1 
ATOM   4895 C C   . LYS C 3 32  ? 191.737 186.733 206.788 1.00 103.55 ? 32  LYS D C   1 
ATOM   4896 O O   . LYS C 3 32  ? 191.875 185.512 206.650 1.00 103.55 ? 32  LYS D O   1 
ATOM   4897 C CB  . LYS C 3 32  ? 192.511 187.623 209.020 1.00 103.55 ? 32  LYS D CB  1 
ATOM   4898 C CG  . LYS C 3 32  ? 192.560 186.286 209.774 1.00 103.55 ? 32  LYS D CG  1 
ATOM   4899 C CD  . LYS C 3 32  ? 191.204 185.614 209.958 1.00 103.55 ? 32  LYS D CD  1 
ATOM   4900 C CE  . LYS C 3 32  ? 190.337 186.363 210.952 1.00 103.55 ? 32  LYS D CE  1 
ATOM   4901 N NZ  . LYS C 3 32  ? 189.022 185.690 211.137 1.00 103.55 ? 32  LYS D NZ  1 
ATOM   4902 N N   . ALA C 3 33  ? 190.676 187.391 206.312 1.00 99.11  ? 33  ALA D N   1 
ATOM   4903 C CA  . ALA C 3 33  ? 189.675 186.698 205.507 1.00 99.11  ? 33  ALA D CA  1 
ATOM   4904 C C   . ALA C 3 33  ? 190.259 186.237 204.177 1.00 99.11  ? 33  ALA D C   1 
ATOM   4905 O O   . ALA C 3 33  ? 189.978 185.124 203.717 1.00 99.11  ? 33  ALA D O   1 
ATOM   4906 C CB  . ALA C 3 33  ? 188.464 187.601 205.281 1.00 99.11  ? 33  ALA D CB  1 
ATOM   4907 N N   . ALA C 3 34  ? 191.084 187.074 203.548 1.00 99.74  ? 34  ALA D N   1 
ATOM   4908 C CA  . ALA C 3 34  ? 191.764 186.650 202.328 1.00 99.74  ? 34  ALA D CA  1 
ATOM   4909 C C   . ALA C 3 34  ? 192.727 185.502 202.609 1.00 99.74  ? 34  ALA D C   1 
ATOM   4910 O O   . ALA C 3 34  ? 192.818 184.548 201.825 1.00 99.74  ? 34  ALA D O   1 
ATOM   4911 C CB  . ALA C 3 34  ? 192.500 187.831 201.699 1.00 99.74  ? 34  ALA D CB  1 
ATOM   4912 N N   . ALA C 3 35  ? 193.429 185.568 203.743 1.00 95.95  ? 35  ALA D N   1 
ATOM   4913 C CA  . ALA C 3 35  ? 194.388 184.531 204.104 1.00 95.95  ? 35  ALA D CA  1 
ATOM   4914 C C   . ALA C 3 35  ? 193.700 183.194 204.352 1.00 95.95  ? 35  ALA D C   1 
ATOM   4915 O O   . ALA C 3 35  ? 194.171 182.152 203.887 1.00 95.95  ? 35  ALA D O   1 
ATOM   4916 C CB  . ALA C 3 35  ? 195.186 184.962 205.334 1.00 95.95  ? 35  ALA D CB  1 
ATOM   4917 N N   . ASP C 3 36  ? 192.575 183.196 205.071 1.00 97.65  ? 36  ASP D N   1 
ATOM   4918 C CA  . ASP C 3 36  ? 191.930 181.916 205.335 1.00 97.65  ? 36  ASP D CA  1 
ATOM   4919 C C   . ASP C 3 36  ? 191.127 181.417 204.139 1.00 97.65  ? 36  ASP D C   1 
ATOM   4920 O O   . ASP C 3 36  ? 190.949 180.202 204.002 1.00 97.65  ? 36  ASP D O   1 
ATOM   4921 C CB  . ASP C 3 36  ? 191.087 181.970 206.627 1.00 97.65  ? 36  ASP D CB  1 
ATOM   4922 C CG  . ASP C 3 36  ? 189.961 183.004 206.608 1.00 97.65  ? 36  ASP D CG  1 
ATOM   4923 O OD1 . ASP C 3 36  ? 189.322 183.241 205.569 1.00 97.65  ? 36  ASP D OD1 1 
ATOM   4924 O OD2 . ASP C 3 36  ? 189.713 183.601 207.677 1.00 97.65  ? 36  ASP D OD2 1 
ATOM   4925 N N   . LEU C 3 37  ? 190.682 182.312 203.246 1.00 87.49  ? 37  LEU D N   1 
ATOM   4926 C CA  . LEU C 3 37  ? 190.145 181.857 201.967 1.00 87.49  ? 37  LEU D CA  1 
ATOM   4927 C C   . LEU C 3 37  ? 191.214 181.150 201.144 1.00 87.49  ? 37  LEU D C   1 
ATOM   4928 O O   . LEU C 3 37  ? 190.966 180.077 200.575 1.00 87.49  ? 37  LEU D O   1 
ATOM   4929 C CB  . LEU C 3 37  ? 189.578 183.034 201.180 1.00 87.49  ? 37  LEU D CB  1 
ATOM   4930 C CG  . LEU C 3 37  ? 188.516 182.634 200.159 1.00 87.49  ? 37  LEU D CG  1 
ATOM   4931 C CD1 . LEU C 3 37  ? 187.189 182.406 200.854 1.00 87.49  ? 37  LEU D CD1 1 
ATOM   4932 C CD2 . LEU C 3 37  ? 188.392 183.678 199.070 1.00 87.49  ? 37  LEU D CD2 1 
ATOM   4933 N N   . MET C 3 38  ? 192.415 181.733 201.083 1.00 88.94  ? 38  MET D N   1 
ATOM   4934 C CA  . MET C 3 38  ? 193.526 181.095 200.384 1.00 88.94  ? 38  MET D CA  1 
ATOM   4935 C C   . MET C 3 38  ? 193.912 179.779 201.049 1.00 88.94  ? 38  MET D C   1 
ATOM   4936 O O   . MET C 3 38  ? 194.255 178.807 200.367 1.00 88.94  ? 38  MET D O   1 
ATOM   4937 C CB  . MET C 3 38  ? 194.720 182.048 200.338 1.00 88.94  ? 38  MET D CB  1 
ATOM   4938 C CG  . MET C 3 38  ? 195.918 181.523 199.572 1.00 88.94  ? 38  MET D CG  1 
ATOM   4939 S SD  . MET C 3 38  ? 197.304 182.673 199.599 1.00 88.94  ? 38  MET D SD  1 
ATOM   4940 C CE  . MET C 3 38  ? 196.663 183.983 198.563 1.00 88.94  ? 38  MET D CE  1 
ATOM   4941 N N   . ALA C 3 39  ? 193.857 179.734 202.382 1.00 81.45  ? 39  ALA D N   1 
ATOM   4942 C CA  . ALA C 3 39  ? 194.172 178.510 203.109 1.00 81.45  ? 39  ALA D CA  1 
ATOM   4943 C C   . ALA C 3 39  ? 193.159 177.411 202.816 1.00 81.45  ? 39  ALA D C   1 
ATOM   4944 O O   . ALA C 3 39  ? 193.534 176.244 202.657 1.00 81.45  ? 39  ALA D O   1 
ATOM   4945 C CB  . ALA C 3 39  ? 194.236 178.795 204.609 1.00 81.45  ? 39  ALA D CB  1 
ATOM   4946 N N   . TYR C 3 40  ? 191.872 177.760 202.742 1.00 74.67  ? 40  TYR D N   1 
ATOM   4947 C CA  . TYR C 3 40  ? 190.869 176.757 202.399 1.00 74.67  ? 40  TYR D CA  1 
ATOM   4948 C C   . TYR C 3 40  ? 191.011 176.310 200.954 1.00 74.67  ? 40  TYR D C   1 
ATOM   4949 O O   . TYR C 3 40  ? 190.730 175.150 200.630 1.00 74.67  ? 40  TYR D O   1 
ATOM   4950 C CB  . TYR C 3 40  ? 189.459 177.286 202.650 1.00 74.67  ? 40  TYR D CB  1 
ATOM   4951 C CG  . TYR C 3 40  ? 188.398 176.216 202.504 1.00 74.67  ? 40  TYR D CG  1 
ATOM   4952 C CD1 . TYR C 3 40  ? 188.100 175.362 203.557 1.00 74.67  ? 40  TYR D CD1 1 
ATOM   4953 C CD2 . TYR C 3 40  ? 187.698 176.059 201.316 1.00 74.67  ? 40  TYR D CD2 1 
ATOM   4954 C CE1 . TYR C 3 40  ? 187.136 174.377 203.429 1.00 74.67  ? 40  TYR D CE1 1 
ATOM   4955 C CE2 . TYR C 3 40  ? 186.735 175.079 201.179 1.00 74.67  ? 40  TYR D CE2 1 
ATOM   4956 C CZ  . TYR C 3 40  ? 186.457 174.242 202.238 1.00 74.67  ? 40  TYR D CZ  1 
ATOM   4957 O OH  . TYR C 3 40  ? 185.496 173.267 202.104 1.00 74.67  ? 40  TYR D OH  1 
ATOM   4958 N N   . CYS C 3 41  ? 191.426 177.215 200.067 1.00 80.43  ? 41  CYS D N   1 
ATOM   4959 C CA  . CYS C 3 41  ? 191.618 176.823 198.675 1.00 80.43  ? 41  CYS D CA  1 
ATOM   4960 C C   . CYS C 3 41  ? 192.812 175.887 198.510 1.00 80.43  ? 41  CYS D C   1 
ATOM   4961 O O   . CYS C 3 41  ? 192.731 174.898 197.774 1.00 80.43  ? 41  CYS D O   1 
ATOM   4962 C CB  . CYS C 3 41  ? 191.771 178.060 197.798 1.00 80.43  ? 41  CYS D CB  1 
ATOM   4963 S SG  . CYS C 3 41  ? 190.190 178.737 197.279 1.00 80.43  ? 41  CYS D SG  1 
ATOM   4964 N N   . GLU C 3 42  ? 193.927 176.176 199.185 1.00 75.90  ? 42  GLU D N   1 
ATOM   4965 C CA  . GLU C 3 42  ? 195.103 175.323 199.043 1.00 75.90  ? 42  GLU D CA  1 
ATOM   4966 C C   . GLU C 3 42  ? 194.972 174.026 199.834 1.00 75.90  ? 42  GLU D C   1 
ATOM   4967 O O   . GLU C 3 42  ? 195.576 173.016 199.459 1.00 75.90  ? 42  GLU D O   1 
ATOM   4968 C CB  . GLU C 3 42  ? 196.371 176.079 199.458 1.00 75.90  ? 42  GLU D CB  1 
ATOM   4969 C CG  . GLU C 3 42  ? 196.459 176.463 200.929 1.00 75.90  ? 42  GLU D CG  1 
ATOM   4970 C CD  . GLU C 3 42  ? 197.213 175.440 201.754 1.00 75.90  ? 42  GLU D CD  1 
ATOM   4971 O OE1 . GLU C 3 42  ? 197.979 174.652 201.163 1.00 75.90  ? 42  GLU D OE1 1 
ATOM   4972 O OE2 . GLU C 3 42  ? 197.034 175.420 202.989 1.00 75.90  ? 42  GLU D OE2 1 
ATOM   4973 N N   . ALA C 3 43  ? 194.202 174.031 200.922 1.00 69.69  ? 43  ALA D N   1 
ATOM   4974 C CA  . ALA C 3 43  ? 194.040 172.833 201.730 1.00 69.69  ? 43  ALA D CA  1 
ATOM   4975 C C   . ALA C 3 43  ? 193.086 171.832 201.102 1.00 69.69  ? 43  ALA D C   1 
ATOM   4976 O O   . ALA C 3 43  ? 193.118 170.652 201.466 1.00 69.69  ? 43  ALA D O   1 
ATOM   4977 C CB  . ALA C 3 43  ? 193.547 173.205 203.129 1.00 69.69  ? 43  ALA D CB  1 
ATOM   4978 N N   . HIS C 3 44  ? 192.237 172.272 200.175 1.00 70.05  ? 44  HIS D N   1 
ATOM   4979 C CA  . HIS C 3 44  ? 191.314 171.384 199.484 1.00 70.05  ? 44  HIS D CA  1 
ATOM   4980 C C   . HIS C 3 44  ? 191.544 171.359 197.980 1.00 70.05  ? 44  HIS D C   1 
ATOM   4981 O O   . HIS C 3 44  ? 190.670 170.894 197.239 1.00 70.05  ? 44  HIS D O   1 
ATOM   4982 C CB  . HIS C 3 44  ? 189.866 171.776 199.792 1.00 70.05  ? 44  HIS D CB  1 
ATOM   4983 C CG  . HIS C 3 44  ? 189.425 171.413 201.175 1.00 70.05  ? 44  HIS D CG  1 
ATOM   4984 N ND1 . HIS C 3 44  ? 188.300 170.656 201.420 1.00 70.05  ? 44  HIS D ND1 1 
ATOM   4985 C CD2 . HIS C 3 44  ? 189.962 171.691 202.386 1.00 70.05  ? 44  HIS D CD2 1 
ATOM   4986 C CE1 . HIS C 3 44  ? 188.159 170.490 202.723 1.00 70.05  ? 44  HIS D CE1 1 
ATOM   4987 N NE2 . HIS C 3 44  ? 189.155 171.107 203.332 1.00 70.05  ? 44  HIS D NE2 1 
ATOM   4988 N N   . ALA C 3 45  ? 192.697 171.843 197.510 1.00 73.66  ? 45  ALA D N   1 
ATOM   4989 C CA  . ALA C 3 45  ? 193.001 171.786 196.084 1.00 73.66  ? 45  ALA D CA  1 
ATOM   4990 C C   . ALA C 3 45  ? 193.232 170.356 195.613 1.00 73.66  ? 45  ALA D C   1 
ATOM   4991 O O   . ALA C 3 45  ? 192.991 170.044 194.441 1.00 73.66  ? 45  ALA D O   1 
ATOM   4992 C CB  . ALA C 3 45  ? 194.220 172.651 195.770 1.00 73.66  ? 45  ALA D CB  1 
ATOM   4993 N N   . LYS C 3 46  ? 193.707 169.481 196.500 1.00 67.32  ? 46  LYS D N   1 
ATOM   4994 C CA  . LYS C 3 46  ? 193.883 168.080 196.135 1.00 67.32  ? 46  LYS D CA  1 
ATOM   4995 C C   . LYS C 3 46  ? 192.541 167.384 195.955 1.00 67.32  ? 46  LYS D C   1 
ATOM   4996 O O   . LYS C 3 46  ? 192.389 166.534 195.070 1.00 67.32  ? 46  LYS D O   1 
ATOM   4997 C CB  . LYS C 3 46  ? 194.719 167.362 197.193 1.00 67.32  ? 46  LYS D CB  1 
ATOM   4998 C CG  . LYS C 3 46  ? 196.100 167.957 197.403 1.00 67.32  ? 46  LYS D CG  1 
ATOM   4999 C CD  . LYS C 3 46  ? 196.960 167.801 196.162 1.00 67.32  ? 46  LYS D CD  1 
ATOM   5000 C CE  . LYS C 3 46  ? 198.362 168.333 196.398 1.00 67.32  ? 46  LYS D CE  1 
ATOM   5001 N NZ  . LYS C 3 46  ? 199.203 168.222 195.177 1.00 67.32  ? 46  LYS D NZ  1 
ATOM   5002 N N   . GLU C 3 47  ? 191.558 167.730 196.780 1.00 64.62  ? 47  GLU D N   1 
ATOM   5003 C CA  . GLU C 3 47  ? 190.246 167.086 196.732 1.00 64.62  ? 47  GLU D CA  1 
ATOM   5004 C C   . GLU C 3 47  ? 189.294 167.822 195.796 1.00 64.62  ? 47  GLU D C   1 
ATOM   5005 O O   . GLU C 3 47  ? 188.208 168.239 196.190 1.00 64.62  ? 47  GLU D O   1 
ATOM   5006 C CB  . GLU C 3 47  ? 189.665 166.990 198.137 1.00 64.62  ? 47  GLU D CB  1 
ATOM   5007 N N   . ASP C 3 48  ? 189.699 167.985 194.539 1.00 62.40  ? 48  ASP D N   1 
ATOM   5008 C CA  . ASP C 3 48  ? 188.850 168.643 193.555 1.00 62.40  ? 48  ASP D CA  1 
ATOM   5009 C C   . ASP C 3 48  ? 189.174 168.139 192.154 1.00 62.40  ? 48  ASP D C   1 
ATOM   5010 O O   . ASP C 3 48  ? 190.214 168.500 191.587 1.00 62.40  ? 48  ASP D O   1 
ATOM   5011 C CB  . ASP C 3 48  ? 189.017 170.160 193.627 1.00 62.40  ? 48  ASP D CB  1 
ATOM   5012 C CG  . ASP C 3 48  ? 187.831 170.902 193.046 1.00 62.40  ? 48  ASP D CG  1 
ATOM   5013 O OD1 . ASP C 3 48  ? 187.816 171.130 191.820 1.00 62.40  ? 48  ASP D OD1 1 
ATOM   5014 O OD2 . ASP C 3 48  ? 186.910 171.251 193.815 1.00 62.40  ? 48  ASP D OD2 1 
ATOM   5015 N N   . PRO C 3 49  ? 188.320 167.290 191.577 1.00 58.35  ? 49  PRO D N   1 
ATOM   5016 C CA  . PRO C 3 49  ? 188.575 166.793 190.214 1.00 58.35  ? 49  PRO D CA  1 
ATOM   5017 C C   . PRO C 3 49  ? 188.559 167.870 189.144 1.00 58.35  ? 49  PRO D C   1 
ATOM   5018 O O   . PRO C 3 49  ? 189.164 167.671 188.085 1.00 58.35  ? 49  PRO D O   1 
ATOM   5019 C CB  . PRO C 3 49  ? 187.446 165.777 189.996 1.00 58.35  ? 49  PRO D CB  1 
ATOM   5020 C CG  . PRO C 3 49  ? 187.028 165.373 191.368 1.00 58.35  ? 49  PRO D CG  1 
ATOM   5021 C CD  . PRO C 3 49  ? 187.195 166.593 192.219 1.00 58.35  ? 49  PRO D CD  1 
ATOM   5022 N N   . LEU C 3 50  ? 187.885 168.997 189.376 1.00 57.30  ? 50  LEU D N   1 
ATOM   5023 C CA  . LEU C 3 50  ? 187.884 170.067 188.385 1.00 57.30  ? 50  LEU D CA  1 
ATOM   5024 C C   . LEU C 3 50  ? 189.237 170.763 188.306 1.00 57.30  ? 50  LEU D C   1 
ATOM   5025 O O   . LEU C 3 50  ? 189.602 171.281 187.245 1.00 57.30  ? 50  LEU D O   1 
ATOM   5026 C CB  . LEU C 3 50  ? 186.783 171.080 188.705 1.00 57.30  ? 50  LEU D CB  1 
ATOM   5027 C CG  . LEU C 3 50  ? 185.337 170.569 188.702 1.00 57.30  ? 50  LEU D CG  1 
ATOM   5028 C CD1 . LEU C 3 50  ? 184.361 171.731 188.699 1.00 57.30  ? 50  LEU D CD1 1 
ATOM   5029 C CD2 . LEU C 3 50  ? 185.067 169.640 187.535 1.00 57.30  ? 50  LEU D CD2 1 
ATOM   5030 N N   . LEU C 3 51  ? 189.986 170.789 189.409 1.00 60.13  ? 51  LEU D N   1 
ATOM   5031 C CA  . LEU C 3 51  ? 191.339 171.335 189.380 1.00 60.13  ? 51  LEU D CA  1 
ATOM   5032 C C   . LEU C 3 51  ? 192.312 170.346 188.751 1.00 60.13  ? 51  LEU D C   1 
ATOM   5033 O O   . LEU C 3 51  ? 192.960 170.645 187.741 1.00 60.13  ? 51  LEU D O   1 
ATOM   5034 C CB  . LEU C 3 51  ? 191.788 171.706 190.795 1.00 60.13  ? 51  LEU D CB  1 
ATOM   5035 C CG  . LEU C 3 51  ? 191.586 173.145 191.273 1.00 60.13  ? 51  LEU D CG  1 
ATOM   5036 C CD1 . LEU C 3 51  ? 192.395 174.096 190.403 1.00 60.13  ? 51  LEU D CD1 1 
ATOM   5037 C CD2 . LEU C 3 51  ? 190.115 173.541 191.305 1.00 60.13  ? 51  LEU D CD2 1 
ATOM   5038 N N   . THR C 3 52  ? 192.434 169.159 189.345 1.00 66.51  ? 52  THR D N   1 
ATOM   5039 C CA  . THR C 3 52  ? 193.312 168.111 188.842 1.00 66.51  ? 52  THR D CA  1 
ATOM   5040 C C   . THR C 3 52  ? 192.471 167.001 188.233 1.00 66.51  ? 52  THR D C   1 
ATOM   5041 O O   . THR C 3 52  ? 191.671 166.382 188.951 1.00 66.51  ? 52  THR D O   1 
ATOM   5042 C CB  . THR C 3 52  ? 194.193 167.558 189.960 1.00 66.51  ? 52  THR D CB  1 
ATOM   5043 O OG1 . THR C 3 52  ? 193.376 166.865 190.913 1.00 66.51  ? 52  THR D OG1 1 
ATOM   5044 C CG2 . THR C 3 52  ? 194.939 168.686 190.660 1.00 66.51  ? 52  THR D CG2 1 
ATOM   5045 N N   . PRO C 3 53  ? 192.605 166.719 186.936 1.00 72.94  ? 53  PRO D N   1 
ATOM   5046 C CA  . PRO C 3 53  ? 191.757 165.694 186.310 1.00 72.94  ? 53  PRO D CA  1 
ATOM   5047 C C   . PRO C 3 53  ? 192.135 164.293 186.774 1.00 72.94  ? 53  PRO D C   1 
ATOM   5048 O O   . PRO C 3 53  ? 193.290 163.875 186.665 1.00 72.94  ? 53  PRO D O   1 
ATOM   5049 C CB  . PRO C 3 53  ? 192.018 165.883 184.811 1.00 72.94  ? 53  PRO D CB  1 
ATOM   5050 C CG  . PRO C 3 53  ? 193.357 166.539 184.739 1.00 72.94  ? 53  PRO D CG  1 
ATOM   5051 C CD  . PRO C 3 53  ? 193.477 167.397 185.962 1.00 72.94  ? 53  PRO D CD  1 
ATOM   5052 N N   . VAL C 3 54  ? 191.147 163.574 187.297 1.00 75.91  ? 54  VAL D N   1 
ATOM   5053 C CA  . VAL C 3 54  ? 191.324 162.209 187.787 1.00 75.91  ? 54  VAL D CA  1 
ATOM   5054 C C   . VAL C 3 54  ? 191.527 161.281 186.593 1.00 75.91  ? 54  VAL D C   1 
ATOM   5055 O O   . VAL C 3 54  ? 191.037 161.581 185.495 1.00 75.91  ? 54  VAL D O   1 
ATOM   5056 C CB  . VAL C 3 54  ? 190.124 161.777 188.646 1.00 75.91  ? 54  VAL D CB  1 
ATOM   5057 N N   . PRO C 3 55  ? 192.242 160.148 186.746 1.00 79.73  ? 55  PRO D N   1 
ATOM   5058 C CA  . PRO C 3 55  ? 192.485 159.269 185.591 1.00 79.73  ? 55  PRO D CA  1 
ATOM   5059 C C   . PRO C 3 55  ? 191.254 158.496 185.142 1.00 79.73  ? 55  PRO D C   1 
ATOM   5060 O O   . PRO C 3 55  ? 190.155 158.706 185.660 1.00 79.73  ? 55  PRO D O   1 
ATOM   5061 C CB  . PRO C 3 55  ? 193.581 158.323 186.097 1.00 79.73  ? 55  PRO D CB  1 
ATOM   5062 C CG  . PRO C 3 55  ? 193.414 158.311 187.572 1.00 79.73  ? 55  PRO D CG  1 
ATOM   5063 C CD  . PRO C 3 55  ? 192.977 159.696 187.942 1.00 79.73  ? 55  PRO D CD  1 
ATOM   5064 N N   . ALA C 3 56  ? 191.436 157.598 184.169 1.00 83.20  ? 56  ALA D N   1 
ATOM   5065 C CA  . ALA C 3 56  ? 190.303 156.907 183.559 1.00 83.20  ? 56  ALA D CA  1 
ATOM   5066 C C   . ALA C 3 56  ? 189.669 155.889 184.499 1.00 83.20  ? 56  ALA D C   1 
ATOM   5067 O O   . ALA C 3 56  ? 188.481 155.579 184.355 1.00 83.20  ? 56  ALA D O   1 
ATOM   5068 C CB  . ALA C 3 56  ? 190.742 156.225 182.264 1.00 83.20  ? 56  ALA D CB  1 
ATOM   5069 N N   . SER C 3 57  ? 190.442 155.336 185.440 1.00 86.52  ? 57  SER D N   1 
ATOM   5070 C CA  . SER C 3 57  ? 189.865 154.442 186.441 1.00 86.52  ? 57  SER D CA  1 
ATOM   5071 C C   . SER C 3 57  ? 188.893 155.192 187.341 1.00 86.52  ? 57  SER D C   1 
ATOM   5072 O O   . SER C 3 57  ? 187.826 154.674 187.691 1.00 86.52  ? 57  SER D O   1 
ATOM   5073 C CB  . SER C 3 57  ? 190.973 153.789 187.267 1.00 86.52  ? 57  SER D CB  1 
ATOM   5074 N N   . GLU C 3 58  ? 189.248 156.414 187.721 1.00 76.66  ? 58  GLU D N   1 
ATOM   5075 C CA  . GLU C 3 58  ? 188.335 157.344 188.367 1.00 76.66  ? 58  GLU D CA  1 
ATOM   5076 C C   . GLU C 3 58  ? 187.580 158.102 187.272 1.00 76.66  ? 58  GLU D C   1 
ATOM   5077 O O   . GLU C 3 58  ? 187.559 157.667 186.117 1.00 76.66  ? 58  GLU D O   1 
ATOM   5078 C CB  . GLU C 3 58  ? 189.110 158.261 189.317 1.00 76.66  ? 58  GLU D CB  1 
ATOM   5079 N N   . ASN C 3 59  ? 186.929 159.218 187.630 1.00 70.50  ? 59  ASN D N   1 
ATOM   5080 C CA  . ASN C 3 59  ? 186.185 160.093 186.722 1.00 70.50  ? 59  ASN D CA  1 
ATOM   5081 C C   . ASN C 3 59  ? 185.089 159.324 185.995 1.00 70.50  ? 59  ASN D C   1 
ATOM   5082 O O   . ASN C 3 59  ? 185.212 159.068 184.791 1.00 70.50  ? 59  ASN D O   1 
ATOM   5083 C CB  . ASN C 3 59  ? 187.118 160.762 185.707 1.00 70.50  ? 59  ASN D CB  1 
ATOM   5084 C CG  . ASN C 3 59  ? 187.621 162.109 186.175 1.00 70.50  ? 59  ASN D CG  1 
ATOM   5085 O OD1 . ASN C 3 59  ? 187.236 162.593 187.238 1.00 70.50  ? 59  ASN D OD1 1 
ATOM   5086 N ND2 . ASN C 3 59  ? 188.492 162.723 185.384 1.00 70.50  ? 59  ASN D ND2 1 
ATOM   5087 N N   . PRO C 3 60  ? 184.007 158.944 186.675 1.00 65.30  ? 60  PRO D N   1 
ATOM   5088 C CA  . PRO C 3 60  ? 183.008 158.053 186.069 1.00 65.30  ? 60  PRO D CA  1 
ATOM   5089 C C   . PRO C 3 60  ? 182.154 158.682 184.977 1.00 65.30  ? 60  PRO D C   1 
ATOM   5090 O O   . PRO C 3 60  ? 181.168 158.065 184.565 1.00 65.30  ? 60  PRO D O   1 
ATOM   5091 C CB  . PRO C 3 60  ? 182.143 157.643 187.272 1.00 65.30  ? 60  PRO D CB  1 
ATOM   5092 C CG  . PRO C 3 60  ? 182.326 158.718 188.268 1.00 65.30  ? 60  PRO D CG  1 
ATOM   5093 C CD  . PRO C 3 60  ? 183.688 159.276 188.075 1.00 65.30  ? 60  PRO D CD  1 
ATOM   5094 N N   . PHE C 3 61  ? 182.487 159.878 184.499 1.00 63.87  ? 61  PHE D N   1 
ATOM   5095 C CA  . PHE C 3 61  ? 181.850 160.446 183.313 1.00 63.87  ? 61  PHE D CA  1 
ATOM   5096 C C   . PHE C 3 61  ? 182.646 160.084 182.057 1.00 63.87  ? 61  PHE D C   1 
ATOM   5097 O O   . PHE C 3 61  ? 183.136 160.937 181.321 1.00 63.87  ? 61  PHE D O   1 
ATOM   5098 C CB  . PHE C 3 61  ? 181.702 161.955 183.466 1.00 63.87  ? 61  PHE D CB  1 
ATOM   5099 C CG  . PHE C 3 61  ? 180.594 162.354 184.384 1.00 63.87  ? 61  PHE D CG  1 
ATOM   5100 C CD1 . PHE C 3 61  ? 179.276 162.168 184.011 1.00 63.87  ? 61  PHE D CD1 1 
ATOM   5101 C CD2 . PHE C 3 61  ? 180.865 162.893 185.628 1.00 63.87  ? 61  PHE D CD2 1 
ATOM   5102 C CE1 . PHE C 3 61  ? 178.250 162.523 184.854 1.00 63.87  ? 61  PHE D CE1 1 
ATOM   5103 C CE2 . PHE C 3 61  ? 179.839 163.246 186.479 1.00 63.87  ? 61  PHE D CE2 1 
ATOM   5104 C CZ  . PHE C 3 61  ? 178.530 163.065 186.089 1.00 63.87  ? 61  PHE D CZ  1 
ATOM   5105 N N   . ARG C 3 62  ? 182.773 158.782 181.825 1.00 67.63  ? 62  ARG D N   1 
ATOM   5106 C CA  . ARG C 3 62  ? 183.505 158.282 180.665 1.00 67.63  ? 62  ARG D CA  1 
ATOM   5107 C C   . ARG C 3 62  ? 182.861 157.015 180.113 1.00 67.63  ? 62  ARG D C   1 
ATOM   5108 O O   . ARG C 3 62  ? 181.682 157.010 179.757 1.00 67.63  ? 62  ARG D O   1 
ATOM   5109 C CB  . ARG C 3 62  ? 184.968 158.014 181.028 1.00 67.63  ? 62  ARG D CB  1 
ATOM   5110 N N   . LEU D 4 5   ? 173.564 144.913 179.391 1.00 126.91 ? 5   LEU B N   1 
ATOM   5111 C CA  . LEU D 4 5   ? 174.287 144.788 180.650 1.00 126.91 ? 5   LEU B CA  1 
ATOM   5112 C C   . LEU D 4 5   ? 173.420 144.115 181.709 1.00 126.91 ? 5   LEU B C   1 
ATOM   5113 O O   . LEU D 4 5   ? 172.840 143.057 181.466 1.00 126.91 ? 5   LEU B O   1 
ATOM   5114 C CB  . LEU D 4 5   ? 174.754 146.160 181.138 1.00 126.91 ? 5   LEU B CB  1 
ATOM   5115 C CG  . LEU D 4 5   ? 175.786 146.872 180.263 1.00 126.91 ? 5   LEU B CG  1 
ATOM   5116 C CD1 . LEU D 4 5   ? 176.157 148.221 180.861 1.00 126.91 ? 5   LEU B CD1 1 
ATOM   5117 C CD2 . LEU D 4 5   ? 177.022 146.005 180.073 1.00 126.91 ? 5   LEU B CD2 1 
ATOM   5118 N N   . SER D 4 6   ? 173.341 144.732 182.886 1.00 126.39 ? 6   SER B N   1 
ATOM   5119 C CA  . SER D 4 6   ? 172.519 144.198 183.961 1.00 126.39 ? 6   SER B CA  1 
ATOM   5120 C C   . SER D 4 6   ? 171.039 144.367 183.637 1.00 126.39 ? 6   SER B C   1 
ATOM   5121 O O   . SER D 4 6   ? 170.644 145.259 182.882 1.00 126.39 ? 6   SER B O   1 
ATOM   5122 C CB  . SER D 4 6   ? 172.851 144.892 185.282 1.00 126.39 ? 6   SER B CB  1 
ATOM   5123 O OG  . SER D 4 6   ? 174.233 144.792 185.577 1.00 126.39 ? 6   SER B OG  1 
ATOM   5124 N N   . ALA D 4 7   ? 170.219 143.484 184.213 1.00 128.53 ? 7   ALA B N   1 
ATOM   5125 C CA  . ALA D 4 7   ? 168.784 143.510 183.944 1.00 128.53 ? 7   ALA B CA  1 
ATOM   5126 C C   . ALA D 4 7   ? 168.122 144.758 184.512 1.00 128.53 ? 7   ALA B C   1 
ATOM   5127 O O   . ALA D 4 7   ? 167.183 145.290 183.908 1.00 128.53 ? 7   ALA B O   1 
ATOM   5128 C CB  . ALA D 4 7   ? 168.120 142.254 184.508 1.00 128.53 ? 7   ALA B CB  1 
ATOM   5129 N N   . GLU D 4 8   ? 168.588 145.231 185.670 1.00 128.70 ? 8   GLU B N   1 
ATOM   5130 C CA  . GLU D 4 8   ? 168.042 146.455 186.251 1.00 128.70 ? 8   GLU B CA  1 
ATOM   5131 C C   . GLU D 4 8   ? 168.365 147.665 185.382 1.00 128.70 ? 8   GLU B C   1 
ATOM   5132 O O   . GLU D 4 8   ? 167.530 148.562 185.210 1.00 128.70 ? 8   GLU B O   1 
ATOM   5133 C CB  . GLU D 4 8   ? 168.581 146.645 187.669 1.00 128.70 ? 8   GLU B CB  1 
ATOM   5134 C CG  . GLU D 4 8   ? 168.160 145.554 188.642 1.00 128.70 ? 8   GLU B CG  1 
ATOM   5135 C CD  . GLU D 4 8   ? 166.674 145.576 188.943 1.00 128.70 ? 8   GLU B CD  1 
ATOM   5136 O OE1 . GLU D 4 8   ? 166.080 146.675 188.946 1.00 128.70 ? 8   GLU B OE1 1 
ATOM   5137 O OE2 . GLU D 4 8   ? 166.098 144.493 189.176 1.00 128.70 ? 8   GLU B OE2 1 
ATOM   5138 N N   . ASP D 4 9   ? 169.577 147.702 184.820 1.00 124.13 ? 9   ASP B N   1 
ATOM   5139 C CA  . ASP D 4 9   ? 169.948 148.788 183.918 1.00 124.13 ? 9   ASP B CA  1 
ATOM   5140 C C   . ASP D 4 9   ? 169.120 148.755 182.639 1.00 124.13 ? 9   ASP B C   1 
ATOM   5141 O O   . ASP D 4 9   ? 168.716 149.806 182.129 1.00 124.13 ? 9   ASP B O   1 
ATOM   5142 C CB  . ASP D 4 9   ? 171.440 148.718 183.596 1.00 124.13 ? 9   ASP B CB  1 
ATOM   5143 C CG  . ASP D 4 9   ? 172.311 149.050 184.791 1.00 124.13 ? 9   ASP B CG  1 
ATOM   5144 O OD1 . ASP D 4 9   ? 171.857 149.821 185.663 1.00 124.13 ? 9   ASP B OD1 1 
ATOM   5145 O OD2 . ASP D 4 9   ? 173.450 148.543 184.860 1.00 124.13 ? 9   ASP B OD2 1 
ATOM   5146 N N   . LYS D 4 10  ? 168.852 147.557 182.110 1.00 122.37 ? 10  LYS B N   1 
ATOM   5147 C CA  . LYS D 4 10  ? 168.005 147.438 180.926 1.00 122.37 ? 10  LYS B CA  1 
ATOM   5148 C C   . LYS D 4 10  ? 166.572 147.860 181.225 1.00 122.37 ? 10  LYS B C   1 
ATOM   5149 O O   . LYS D 4 10  ? 165.919 148.493 180.386 1.00 122.37 ? 10  LYS B O   1 
ATOM   5150 C CB  . LYS D 4 10  ? 168.044 146.007 180.389 1.00 122.37 ? 10  LYS B CB  1 
ATOM   5151 C CG  . LYS D 4 10  ? 169.402 145.561 179.854 1.00 122.37 ? 10  LYS B CG  1 
ATOM   5152 C CD  . LYS D 4 10  ? 169.739 146.213 178.518 1.00 122.37 ? 10  LYS B CD  1 
ATOM   5153 C CE  . LYS D 4 10  ? 170.885 147.209 178.649 1.00 122.37 ? 10  LYS B CE  1 
ATOM   5154 N NZ  . LYS D 4 10  ? 171.298 147.757 177.328 1.00 122.37 ? 10  LYS B NZ  1 
ATOM   5155 N N   . ALA D 4 11  ? 166.067 147.522 182.415 1.00 122.88 ? 11  ALA B N   1 
ATOM   5156 C CA  . ALA D 4 11  ? 164.740 147.979 182.817 1.00 122.88 ? 11  ALA B CA  1 
ATOM   5157 C C   . ALA D 4 11  ? 164.684 149.495 182.963 1.00 122.88 ? 11  ALA B C   1 
ATOM   5158 O O   . ALA D 4 11  ? 163.691 150.118 182.567 1.00 122.88 ? 11  ALA B O   1 
ATOM   5159 C CB  . ALA D 4 11  ? 164.325 147.305 184.124 1.00 122.88 ? 11  ALA B CB  1 
ATOM   5160 N N   . ALA D 4 12  ? 165.738 150.101 183.519 1.00 119.53 ? 12  ALA B N   1 
ATOM   5161 C CA  . ALA D 4 12  ? 165.797 151.557 183.624 1.00 119.53 ? 12  ALA B CA  1 
ATOM   5162 C C   . ALA D 4 12  ? 165.853 152.212 182.249 1.00 119.53 ? 12  ALA B C   1 
ATOM   5163 O O   . ALA D 4 12  ? 165.215 153.246 182.024 1.00 119.53 ? 12  ALA B O   1 
ATOM   5164 C CB  . ALA D 4 12  ? 167.001 151.975 184.466 1.00 119.53 ? 12  ALA B CB  1 
ATOM   5165 N N   . VAL D 4 13  ? 166.608 151.621 181.318 1.00 117.41 ? 13  VAL B N   1 
ATOM   5166 C CA  . VAL D 4 13  ? 166.683 152.143 179.955 1.00 117.41 ? 13  VAL B CA  1 
ATOM   5167 C C   . VAL D 4 13  ? 165.324 152.045 179.269 1.00 117.41 ? 13  VAL B C   1 
ATOM   5168 O O   . VAL D 4 13  ? 164.889 152.981 178.584 1.00 117.41 ? 13  VAL B O   1 
ATOM   5169 C CB  . VAL D 4 13  ? 167.784 151.403 179.167 1.00 117.41 ? 13  VAL B CB  1 
ATOM   5170 C CG1 . VAL D 4 13  ? 167.616 151.588 177.665 1.00 117.41 ? 13  VAL B CG1 1 
ATOM   5171 C CG2 . VAL D 4 13  ? 169.157 151.888 179.602 1.00 117.41 ? 13  VAL B CG2 1 
ATOM   5172 N N   . GLU D 4 14  ? 164.628 150.920 179.453 1.00 119.06 ? 14  GLU B N   1 
ATOM   5173 C CA  . GLU D 4 14  ? 163.305 150.753 178.856 1.00 119.06 ? 14  GLU B CA  1 
ATOM   5174 C C   . GLU D 4 14  ? 162.300 151.739 179.442 1.00 119.06 ? 14  GLU B C   1 
ATOM   5175 O O   . GLU D 4 14  ? 161.473 152.299 178.711 1.00 119.06 ? 14  GLU B O   1 
ATOM   5176 C CB  . GLU D 4 14  ? 162.824 149.314 179.041 1.00 119.06 ? 14  GLU B CB  1 
ATOM   5177 C CG  . GLU D 4 14  ? 161.485 149.015 178.385 1.00 119.06 ? 14  GLU B CG  1 
ATOM   5178 C CD  . GLU D 4 14  ? 160.985 147.615 178.684 1.00 119.06 ? 14  GLU B CD  1 
ATOM   5179 O OE1 . GLU D 4 14  ? 161.579 146.648 178.164 1.00 119.06 ? 14  GLU B OE1 1 
ATOM   5180 O OE2 . GLU D 4 14  ? 159.998 147.482 179.438 1.00 119.06 ? 14  GLU B OE2 1 
ATOM   5181 N N   . ARG D 4 15  ? 162.363 151.973 180.756 1.00 115.79 ? 15  ARG B N   1 
ATOM   5182 C CA  . ARG D 4 15  ? 161.480 152.957 181.378 1.00 115.79 ? 15  ARG B CA  1 
ATOM   5183 C C   . ARG D 4 15  ? 161.792 154.368 180.886 1.00 115.79 ? 15  ARG B C   1 
ATOM   5184 O O   . ARG D 4 15  ? 160.877 155.167 180.645 1.00 115.79 ? 15  ARG B O   1 
ATOM   5185 C CB  . ARG D 4 15  ? 161.589 152.867 182.902 1.00 115.79 ? 15  ARG B CB  1 
ATOM   5186 C CG  . ARG D 4 15  ? 161.290 154.161 183.644 1.00 115.79 ? 15  ARG B CG  1 
ATOM   5187 C CD  . ARG D 4 15  ? 161.685 154.083 185.107 1.00 115.79 ? 15  ARG B CD  1 
ATOM   5188 N NE  . ARG D 4 15  ? 161.109 155.183 185.871 1.00 115.79 ? 15  ARG B NE  1 
ATOM   5189 C CZ  . ARG D 4 15  ? 159.867 155.202 186.336 1.00 115.79 ? 15  ARG B CZ  1 
ATOM   5190 N NH1 . ARG D 4 15  ? 159.041 154.187 186.143 1.00 115.79 ? 15  ARG B NH1 1 
ATOM   5191 N NH2 . ARG D 4 15  ? 159.443 156.267 187.008 1.00 115.79 ? 15  ARG B NH2 1 
ATOM   5192 N N   . SER D 4 16  ? 163.081 154.684 180.715 1.00 111.41 ? 16  SER B N   1 
ATOM   5193 C CA  . SER D 4 16  ? 163.476 155.982 180.177 1.00 111.41 ? 16  SER B CA  1 
ATOM   5194 C C   . SER D 4 16  ? 162.972 156.174 178.752 1.00 111.41 ? 16  SER B C   1 
ATOM   5195 O O   . SER D 4 16  ? 162.503 157.259 178.396 1.00 111.41 ? 16  SER B O   1 
ATOM   5196 C CB  . SER D 4 16  ? 164.997 156.128 180.229 1.00 111.41 ? 16  SER B CB  1 
ATOM   5197 O OG  . SER D 4 16  ? 165.426 157.265 179.502 1.00 111.41 ? 16  SER B OG  1 
ATOM   5198 N N   . LYS D 4 17  ? 163.053 155.128 177.926 1.00 111.54 ? 17  LYS B N   1 
ATOM   5199 C CA  . LYS D 4 17  ? 162.532 155.219 176.563 1.00 111.54 ? 17  LYS B CA  1 
ATOM   5200 C C   . LYS D 4 17  ? 161.016 155.371 176.555 1.00 111.54 ? 17  LYS B C   1 
ATOM   5201 O O   . LYS D 4 17  ? 160.469 156.131 175.746 1.00 111.54 ? 17  LYS B O   1 
ATOM   5202 C CB  . LYS D 4 17  ? 162.949 153.993 175.751 1.00 111.54 ? 17  LYS B CB  1 
ATOM   5203 C CG  . LYS D 4 17  ? 164.432 153.934 175.431 1.00 111.54 ? 17  LYS B CG  1 
ATOM   5204 C CD  . LYS D 4 17  ? 164.739 152.822 174.442 1.00 111.54 ? 17  LYS B CD  1 
ATOM   5205 C CE  . LYS D 4 17  ? 164.603 151.453 175.082 1.00 111.54 ? 17  LYS B CE  1 
ATOM   5206 N NZ  . LYS D 4 17  ? 164.987 150.366 174.139 1.00 111.54 ? 17  LYS B NZ  1 
ATOM   5207 N N   . MET D 4 18  ? 160.323 154.660 177.450 1.00 111.09 ? 18  MET B N   1 
ATOM   5208 C CA  . MET D 4 18  ? 158.869 154.772 177.528 1.00 111.09 ? 18  MET B CA  1 
ATOM   5209 C C   . MET D 4 18  ? 158.440 156.174 177.949 1.00 111.09 ? 18  MET B C   1 
ATOM   5210 O O   . MET D 4 18  ? 157.516 156.751 177.359 1.00 111.09 ? 18  MET B O   1 
ATOM   5211 C CB  . MET D 4 18  ? 158.317 153.724 178.495 1.00 111.09 ? 18  MET B CB  1 
ATOM   5212 C CG  . MET D 4 18  ? 156.863 153.931 178.887 1.00 111.09 ? 18  MET B CG  1 
ATOM   5213 S SD  . MET D 4 18  ? 156.248 152.634 179.978 1.00 111.09 ? 18  MET B SD  1 
ATOM   5214 C CE  . MET D 4 18  ? 156.380 151.202 178.909 1.00 111.09 ? 18  MET B CE  1 
ATOM   5215 N N   . ILE D 4 19  ? 159.114 156.754 178.943 1.00 109.32 ? 19  ILE B N   1 
ATOM   5216 C CA  . ILE D 4 19  ? 158.733 158.099 179.360 1.00 109.32 ? 19  ILE B CA  1 
ATOM   5217 C C   . ILE D 4 19  ? 159.213 159.158 178.373 1.00 109.32 ? 19  ILE B C   1 
ATOM   5218 O O   . ILE D 4 19  ? 158.589 160.219 178.281 1.00 109.32 ? 19  ILE B O   1 
ATOM   5219 C CB  . ILE D 4 19  ? 159.214 158.414 180.788 1.00 109.32 ? 19  ILE B CB  1 
ATOM   5220 C CG1 . ILE D 4 19  ? 160.737 158.429 180.884 1.00 109.32 ? 19  ILE B CG1 1 
ATOM   5221 C CG2 . ILE D 4 19  ? 158.626 157.414 181.777 1.00 109.32 ? 19  ILE B CG2 1 
ATOM   5222 C CD1 . ILE D 4 19  ? 161.240 158.790 182.264 1.00 109.32 ? 19  ILE B CD1 1 
ATOM   5223 N N   . ASP D 4 20  ? 160.274 158.895 177.601 1.00 106.66 ? 20  ASP B N   1 
ATOM   5224 C CA  . ASP D 4 20  ? 160.617 159.785 176.494 1.00 106.66 ? 20  ASP B CA  1 
ATOM   5225 C C   . ASP D 4 20  ? 159.550 159.760 175.409 1.00 106.66 ? 20  ASP B C   1 
ATOM   5226 O O   . ASP D 4 20  ? 159.219 160.803 174.836 1.00 106.66 ? 20  ASP B O   1 
ATOM   5227 C CB  . ASP D 4 20  ? 161.979 159.414 175.910 1.00 106.66 ? 20  ASP B CB  1 
ATOM   5228 C CG  . ASP D 4 20  ? 163.123 160.069 176.647 1.00 106.66 ? 20  ASP B CG  1 
ATOM   5229 O OD1 . ASP D 4 20  ? 162.945 161.217 177.098 1.00 106.66 ? 20  ASP B OD1 1 
ATOM   5230 O OD2 . ASP D 4 20  ? 164.197 159.444 176.771 1.00 106.66 ? 20  ASP B OD2 1 
ATOM   5231 N N   . ARG D 4 21  ? 159.007 158.578 175.107 1.00 106.96 ? 21  ARG B N   1 
ATOM   5232 C CA  . ARG D 4 21  ? 157.909 158.492 174.147 1.00 106.96 ? 21  ARG B CA  1 
ATOM   5233 C C   . ARG D 4 21  ? 156.666 159.210 174.663 1.00 106.96 ? 21  ARG B C   1 
ATOM   5234 O O   . ARG D 4 21  ? 155.980 159.905 173.900 1.00 106.96 ? 21  ARG B O   1 
ATOM   5235 C CB  . ARG D 4 21  ? 157.594 157.028 173.837 1.00 106.96 ? 21  ARG B CB  1 
ATOM   5236 C CG  . ARG D 4 21  ? 156.551 156.834 172.747 1.00 106.96 ? 21  ARG B CG  1 
ATOM   5237 C CD  . ARG D 4 21  ? 156.332 155.362 172.438 1.00 106.96 ? 21  ARG B CD  1 
ATOM   5238 N NE  . ARG D 4 21  ? 155.762 154.642 173.571 1.00 106.96 ? 21  ARG B NE  1 
ATOM   5239 C CZ  . ARG D 4 21  ? 156.391 153.689 174.245 1.00 106.96 ? 21  ARG B CZ  1 
ATOM   5240 N NH1 . ARG D 4 21  ? 157.615 153.306 173.922 1.00 106.96 ? 21  ARG B NH1 1 
ATOM   5241 N NH2 . ARG D 4 21  ? 155.776 153.105 175.269 1.00 106.96 ? 21  ARG B NH2 1 
ATOM   5242 N N   . ASN D 4 22  ? 156.367 159.057 175.957 1.00 104.47 ? 22  ASN B N   1 
ATOM   5243 C CA  . ASN D 4 22  ? 155.230 159.759 176.548 1.00 104.47 ? 22  ASN B CA  1 
ATOM   5244 C C   . ASN D 4 22  ? 155.436 161.269 176.528 1.00 104.47 ? 22  ASN B C   1 
ATOM   5245 O O   . ASN D 4 22  ? 154.504 162.027 176.233 1.00 104.47 ? 22  ASN B O   1 
ATOM   5246 C CB  . ASN D 4 22  ? 154.997 159.268 177.976 1.00 104.47 ? 22  ASN B CB  1 
ATOM   5247 C CG  . ASN D 4 22  ? 154.019 158.112 178.041 1.00 104.47 ? 22  ASN B CG  1 
ATOM   5248 O OD1 . ASN D 4 22  ? 154.016 157.237 177.175 1.00 104.47 ? 22  ASN B OD1 1 
ATOM   5249 N ND2 . ASN D 4 22  ? 153.180 158.103 179.071 1.00 104.47 ? 22  ASN B ND2 1 
ATOM   5250 N N   . LEU D 4 23  ? 156.657 161.724 176.820 1.00 100.32 ? 23  LEU B N   1 
ATOM   5251 C CA  . LEU D 4 23  ? 156.961 163.150 176.779 1.00 100.32 ? 23  LEU B CA  1 
ATOM   5252 C C   . LEU D 4 23  ? 156.881 163.691 175.357 1.00 100.32 ? 23  LEU B C   1 
ATOM   5253 O O   . LEU D 4 23  ? 156.427 164.819 175.147 1.00 100.32 ? 23  LEU B O   1 
ATOM   5254 C CB  . LEU D 4 23  ? 158.343 163.398 177.386 1.00 100.32 ? 23  LEU B CB  1 
ATOM   5255 C CG  . LEU D 4 23  ? 158.785 164.821 177.736 1.00 100.32 ? 23  LEU B CG  1 
ATOM   5256 C CD1 . LEU D 4 23  ? 159.668 164.773 178.963 1.00 100.32 ? 23  LEU B CD1 1 
ATOM   5257 C CD2 . LEU D 4 23  ? 159.542 165.479 176.592 1.00 100.32 ? 23  LEU B CD2 1 
ATOM   5258 N N   . ARG D 4 24  ? 157.321 162.904 174.372 1.00 100.76 ? 24  ARG B N   1 
ATOM   5259 C CA  . ARG D 4 24  ? 157.217 163.322 172.978 1.00 100.76 ? 24  ARG B CA  1 
ATOM   5260 C C   . ARG D 4 24  ? 155.764 163.440 172.539 1.00 100.76 ? 24  ARG B C   1 
ATOM   5261 O O   . ARG D 4 24  ? 155.382 164.432 171.907 1.00 100.76 ? 24  ARG B O   1 
ATOM   5262 C CB  . ARG D 4 24  ? 157.972 162.340 172.081 1.00 100.76 ? 24  ARG B CB  1 
ATOM   5263 C CG  . ARG D 4 24  ? 157.919 162.672 170.599 1.00 100.76 ? 24  ARG B CG  1 
ATOM   5264 C CD  . ARG D 4 24  ? 158.935 161.860 169.804 1.00 100.76 ? 24  ARG B CD  1 
ATOM   5265 N NE  . ARG D 4 24  ? 159.213 160.565 170.414 1.00 100.76 ? 24  ARG B NE  1 
ATOM   5266 C CZ  . ARG D 4 24  ? 160.418 160.157 170.791 1.00 100.76 ? 24  ARG B CZ  1 
ATOM   5267 N NH1 . ARG D 4 24  ? 161.491 160.910 170.610 1.00 100.76 ? 24  ARG B NH1 1 
ATOM   5268 N NH2 . ARG D 4 24  ? 160.551 158.962 171.359 1.00 100.76 ? 24  ARG B NH2 1 
ATOM   5269 N N   . GLU D 4 25  ? 154.930 162.457 172.888 1.00 101.44 ? 25  GLU B N   1 
ATOM   5270 C CA  . GLU D 4 25  ? 153.529 162.520 172.488 1.00 101.44 ? 25  GLU B CA  1 
ATOM   5271 C C   . GLU D 4 25  ? 152.740 163.544 173.297 1.00 101.44 ? 25  GLU B C   1 
ATOM   5272 O O   . GLU D 4 25  ? 151.657 163.952 172.866 1.00 101.44 ? 25  GLU B O   1 
ATOM   5273 C CB  . GLU D 4 25  ? 152.875 161.140 172.599 1.00 101.44 ? 25  GLU B CB  1 
ATOM   5274 C CG  . GLU D 4 25  ? 152.507 160.716 174.011 1.00 101.44 ? 25  GLU B CG  1 
ATOM   5275 C CD  . GLU D 4 25  ? 151.798 159.375 174.052 1.00 101.44 ? 25  GLU B CD  1 
ATOM   5276 O OE1 . GLU D 4 25  ? 151.634 158.756 172.980 1.00 101.44 ? 25  GLU B OE1 1 
ATOM   5277 O OE2 . GLU D 4 25  ? 151.403 158.943 175.156 1.00 101.44 ? 25  GLU B OE2 1 
ATOM   5278 N N   . ASP D 4 26  ? 153.253 163.967 174.456 1.00 98.60  ? 26  ASP B N   1 
ATOM   5279 C CA  . ASP D 4 26  ? 152.585 165.019 175.213 1.00 98.60  ? 26  ASP B CA  1 
ATOM   5280 C C   . ASP D 4 26  ? 153.048 166.412 174.801 1.00 98.60  ? 26  ASP B C   1 
ATOM   5281 O O   . ASP D 4 26  ? 152.274 167.370 174.902 1.00 98.60  ? 26  ASP B O   1 
ATOM   5282 C CB  . ASP D 4 26  ? 152.812 164.811 176.710 1.00 98.60  ? 26  ASP B CB  1 
ATOM   5283 C CG  . ASP D 4 26  ? 152.007 163.652 177.264 1.00 98.60  ? 26  ASP B CG  1 
ATOM   5284 O OD1 . ASP D 4 26  ? 150.906 163.386 176.738 1.00 98.60  ? 26  ASP B OD1 1 
ATOM   5285 O OD2 . ASP D 4 26  ? 152.478 163.003 178.222 1.00 98.60  ? 26  ASP B OD2 1 
ATOM   5286 N N   . GLY D 4 27  ? 154.293 166.550 174.343 1.00 92.79  ? 27  GLY B N   1 
ATOM   5287 C CA  . GLY D 4 27  ? 154.812 167.821 173.884 1.00 92.79  ? 27  GLY B CA  1 
ATOM   5288 C C   . GLY D 4 27  ? 154.624 168.101 172.416 1.00 92.79  ? 27  GLY B C   1 
ATOM   5289 O O   . GLY D 4 27  ? 154.844 169.233 171.977 1.00 92.79  ? 27  GLY B O   1 
ATOM   5290 N N   . GLU D 4 28  ? 154.235 167.092 171.633 1.00 91.31  ? 28  GLU B N   1 
ATOM   5291 C CA  . GLU D 4 28  ? 153.887 167.330 170.239 1.00 91.31  ? 28  GLU B CA  1 
ATOM   5292 C C   . GLU D 4 28  ? 152.606 168.139 170.101 1.00 91.31  ? 28  GLU B C   1 
ATOM   5293 O O   . GLU D 4 28  ? 152.456 168.876 169.122 1.00 91.31  ? 28  GLU B O   1 
ATOM   5294 C CB  . GLU D 4 28  ? 153.749 165.997 169.503 1.00 91.31  ? 28  GLU B CB  1 
ATOM   5295 C CG  . GLU D 4 28  ? 154.041 166.066 168.015 1.00 91.31  ? 28  GLU B CG  1 
ATOM   5296 C CD  . GLU D 4 28  ? 153.531 164.850 167.266 1.00 91.31  ? 28  GLU B CD  1 
ATOM   5297 O OE1 . GLU D 4 28  ? 152.776 164.056 167.866 1.00 91.31  ? 28  GLU B OE1 1 
ATOM   5298 O OE2 . GLU D 4 28  ? 153.887 164.686 166.080 1.00 91.31  ? 28  GLU B OE2 1 
ATOM   5299 N N   . LYS D 4 29  ? 151.685 168.020 171.057 1.00 82.79  ? 29  LYS B N   1 
ATOM   5300 C CA  . LYS D 4 29  ? 150.459 168.806 171.032 1.00 82.79  ? 29  LYS B CA  1 
ATOM   5301 C C   . LYS D 4 29  ? 150.652 170.218 171.565 1.00 82.79  ? 29  LYS B C   1 
ATOM   5302 O O   . LYS D 4 29  ? 149.720 171.025 171.481 1.00 82.79  ? 29  LYS B O   1 
ATOM   5303 C CB  . LYS D 4 29  ? 149.359 168.102 171.830 1.00 82.79  ? 29  LYS B CB  1 
ATOM   5304 C CG  . LYS D 4 29  ? 149.470 168.274 173.336 1.00 82.79  ? 29  LYS B CG  1 
ATOM   5305 C CD  . LYS D 4 29  ? 148.286 167.646 174.059 1.00 82.79  ? 29  LYS B CD  1 
ATOM   5306 C CE  . LYS D 4 29  ? 148.053 166.208 173.616 1.00 82.79  ? 29  LYS B CE  1 
ATOM   5307 N NZ  . LYS D 4 29  ? 147.421 165.393 174.690 1.00 82.79  ? 29  LYS B NZ  1 
ATOM   5308 N N   . ALA D 4 30  ? 151.826 170.536 172.112 1.00 77.55  ? 30  ALA B N   1 
ATOM   5309 C CA  . ALA D 4 30  ? 152.105 171.900 172.534 1.00 77.55  ? 30  ALA B CA  1 
ATOM   5310 C C   . ALA D 4 30  ? 152.324 172.837 171.357 1.00 77.55  ? 30  ALA B C   1 
ATOM   5311 O O   . ALA D 4 30  ? 152.145 174.049 171.508 1.00 77.55  ? 30  ALA B O   1 
ATOM   5312 C CB  . ALA D 4 30  ? 153.325 171.932 173.453 1.00 77.55  ? 30  ALA B CB  1 
ATOM   5313 N N   . ALA D 4 31  ? 152.717 172.308 170.197 1.00 73.67  ? 31  ALA B N   1 
ATOM   5314 C CA  . ALA D 4 31  ? 152.782 173.134 168.996 1.00 73.67  ? 31  ALA B CA  1 
ATOM   5315 C C   . ALA D 4 31  ? 151.386 173.451 168.476 1.00 73.67  ? 31  ALA B C   1 
ATOM   5316 O O   . ALA D 4 31  ? 151.130 174.566 168.007 1.00 73.67  ? 31  ALA B O   1 
ATOM   5317 C CB  . ALA D 4 31  ? 153.613 172.439 167.920 1.00 73.67  ? 31  ALA B CB  1 
ATOM   5318 N N   . ARG D 4 32  ? 150.472 172.479 168.546 1.00 74.91  ? 32  ARG B N   1 
ATOM   5319 C CA  . ARG D 4 32  ? 149.089 172.733 168.157 1.00 74.91  ? 32  ARG B CA  1 
ATOM   5320 C C   . ARG D 4 32  ? 148.402 173.670 169.142 1.00 74.91  ? 32  ARG B C   1 
ATOM   5321 O O   . ARG D 4 32  ? 147.574 174.498 168.746 1.00 74.91  ? 32  ARG B O   1 
ATOM   5322 C CB  . ARG D 4 32  ? 148.319 171.418 168.049 1.00 74.91  ? 32  ARG B CB  1 
ATOM   5323 C CG  . ARG D 4 32  ? 148.572 170.647 166.766 1.00 74.91  ? 32  ARG B CG  1 
ATOM   5324 C CD  . ARG D 4 32  ? 149.560 169.518 166.988 1.00 74.91  ? 32  ARG B CD  1 
ATOM   5325 N NE  . ARG D 4 32  ? 149.045 168.544 167.943 1.00 74.91  ? 32  ARG B NE  1 
ATOM   5326 C CZ  . ARG D 4 32  ? 148.223 167.550 167.636 1.00 74.91  ? 32  ARG B CZ  1 
ATOM   5327 N NH1 . ARG D 4 32  ? 147.800 167.360 166.397 1.00 74.91  ? 32  ARG B NH1 1 
ATOM   5328 N NH2 . ARG D 4 32  ? 147.813 166.727 168.597 1.00 74.91  ? 32  ARG B NH2 1 
ATOM   5329 N N   . GLU D 4 33  ? 148.729 173.553 170.426 1.00 67.53  ? 33  GLU B N   1 
ATOM   5330 C CA  . GLU D 4 33  ? 148.179 174.436 171.452 1.00 67.53  ? 33  GLU B CA  1 
ATOM   5331 C C   . GLU D 4 33  ? 148.843 175.794 171.296 1.00 67.53  ? 33  GLU B C   1 
ATOM   5332 O O   . GLU D 4 33  ? 149.904 176.067 171.857 1.00 67.53  ? 33  GLU B O   1 
ATOM   5333 C CB  . GLU D 4 33  ? 148.400 173.858 172.844 1.00 67.53  ? 33  GLU B CB  1 
ATOM   5334 C CG  . GLU D 4 33  ? 147.475 174.422 173.907 1.00 67.53  ? 33  GLU B CG  1 
ATOM   5335 C CD  . GLU D 4 33  ? 146.069 173.871 173.816 1.00 67.53  ? 33  GLU B CD  1 
ATOM   5336 O OE1 . GLU D 4 33  ? 145.905 172.734 173.330 1.00 67.53  ? 33  GLU B OE1 1 
ATOM   5337 O OE2 . GLU D 4 33  ? 145.126 174.576 174.231 1.00 67.53  ? 33  GLU B OE2 1 
ATOM   5338 N N   . VAL D 4 34  ? 148.213 176.654 170.500 1.00 63.80  ? 34  VAL B N   1 
ATOM   5339 C CA  . VAL D 4 34  ? 148.746 177.987 170.276 1.00 63.80  ? 34  VAL B CA  1 
ATOM   5340 C C   . VAL D 4 34  ? 148.427 178.866 171.484 1.00 63.80  ? 34  VAL B C   1 
ATOM   5341 O O   . VAL D 4 34  ? 147.443 178.646 172.202 1.00 63.80  ? 34  VAL B O   1 
ATOM   5342 C CB  . VAL D 4 34  ? 148.173 178.553 168.963 1.00 63.80  ? 34  VAL B CB  1 
ATOM   5343 C CG1 . VAL D 4 34  ? 146.678 178.822 169.079 1.00 63.80  ? 34  VAL B CG1 1 
ATOM   5344 C CG2 . VAL D 4 34  ? 148.943 179.762 168.500 1.00 63.80  ? 34  VAL B CG2 1 
ATOM   5345 N N   . LYS D 4 35  ? 149.286 179.850 171.743 1.00 58.48  ? 35  LYS B N   1 
ATOM   5346 C CA  . LYS D 4 35  ? 149.234 180.603 172.988 1.00 58.48  ? 35  LYS B CA  1 
ATOM   5347 C C   . LYS D 4 35  ? 149.358 182.099 172.732 1.00 58.48  ? 35  LYS B C   1 
ATOM   5348 O O   . LYS D 4 35  ? 150.084 182.530 171.832 1.00 58.48  ? 35  LYS B O   1 
ATOM   5349 C CB  . LYS D 4 35  ? 150.332 180.124 173.933 1.00 58.48  ? 35  LYS B CB  1 
ATOM   5350 C CG  . LYS D 4 35  ? 151.690 180.007 173.280 1.00 58.48  ? 35  LYS B CG  1 
ATOM   5351 C CD  . LYS D 4 35  ? 152.706 179.444 174.249 1.00 58.48  ? 35  LYS B CD  1 
ATOM   5352 C CE  . LYS D 4 35  ? 152.398 177.987 174.542 1.00 58.48  ? 35  LYS B CE  1 
ATOM   5353 N NZ  . LYS D 4 35  ? 152.534 177.143 173.325 1.00 58.48  ? 35  LYS B NZ  1 
ATOM   5354 N N   . LEU D 4 36  ? 148.645 182.884 173.542 1.00 46.93  ? 36  LEU B N   1 
ATOM   5355 C CA  . LEU D 4 36  ? 148.522 184.324 173.374 1.00 46.93  ? 36  LEU B CA  1 
ATOM   5356 C C   . LEU D 4 36  ? 148.870 185.026 174.679 1.00 46.93  ? 36  LEU B C   1 
ATOM   5357 O O   . LEU D 4 36  ? 148.562 184.533 175.768 1.00 46.93  ? 36  LEU B O   1 
ATOM   5358 C CB  . LEU D 4 36  ? 147.097 184.698 172.961 1.00 46.93  ? 36  LEU B CB  1 
ATOM   5359 C CG  . LEU D 4 36  ? 146.624 184.106 171.635 1.00 46.93  ? 36  LEU B CG  1 
ATOM   5360 C CD1 . LEU D 4 36  ? 145.138 184.335 171.440 1.00 46.93  ? 36  LEU B CD1 1 
ATOM   5361 C CD2 . LEU D 4 36  ? 147.412 184.686 170.483 1.00 46.93  ? 36  LEU B CD2 1 
ATOM   5362 N N   . LEU D 4 37  ? 149.498 186.190 174.565 1.00 36.52  ? 37  LEU B N   1 
ATOM   5363 C CA  . LEU D 4 37  ? 149.885 186.998 175.716 1.00 36.52  ? 37  LEU B CA  1 
ATOM   5364 C C   . LEU D 4 37  ? 148.868 188.121 175.868 1.00 36.52  ? 37  LEU B C   1 
ATOM   5365 O O   . LEU D 4 37  ? 148.990 189.167 175.221 1.00 36.52  ? 37  LEU B O   1 
ATOM   5366 C CB  . LEU D 4 37  ? 151.300 187.547 175.541 1.00 36.52  ? 37  LEU B CB  1 
ATOM   5367 C CG  . LEU D 4 37  ? 151.839 188.481 176.622 1.00 36.52  ? 37  LEU B CG  1 
ATOM   5368 C CD1 . LEU D 4 37  ? 151.811 187.815 177.985 1.00 36.52  ? 37  LEU B CD1 1 
ATOM   5369 C CD2 . LEU D 4 37  ? 153.241 188.951 176.278 1.00 36.52  ? 37  LEU B CD2 1 
ATOM   5370 N N   . LEU D 4 38  ? 147.865 187.909 176.711 1.00 37.40  ? 38  LEU B N   1 
ATOM   5371 C CA  . LEU D 4 38  ? 146.842 188.915 176.956 1.00 37.40  ? 38  LEU B CA  1 
ATOM   5372 C C   . LEU D 4 38  ? 147.302 189.805 178.100 1.00 37.40  ? 38  LEU B C   1 
ATOM   5373 O O   . LEU D 4 38  ? 147.566 189.317 179.204 1.00 37.40  ? 38  LEU B O   1 
ATOM   5374 C CB  . LEU D 4 38  ? 145.497 188.271 177.279 1.00 37.40  ? 38  LEU B CB  1 
ATOM   5375 C CG  . LEU D 4 38  ? 144.517 189.159 178.047 1.00 37.40  ? 38  LEU B CG  1 
ATOM   5376 C CD1 . LEU D 4 38  ? 143.933 190.225 177.144 1.00 37.40  ? 38  LEU B CD1 1 
ATOM   5377 C CD2 . LEU D 4 38  ? 143.416 188.325 178.660 1.00 37.40  ? 38  LEU B CD2 1 
ATOM   5378 N N   . LEU D 4 39  ? 147.403 191.102 177.832 1.00 36.73  ? 39  LEU B N   1 
ATOM   5379 C CA  . LEU D 4 39  ? 147.815 192.053 178.850 1.00 36.73  ? 39  LEU B CA  1 
ATOM   5380 C C   . LEU D 4 39  ? 147.201 193.408 178.542 1.00 36.73  ? 39  LEU B C   1 
ATOM   5381 O O   . LEU D 4 39  ? 146.891 193.724 177.392 1.00 36.73  ? 39  LEU B O   1 
ATOM   5382 C CB  . LEU D 4 39  ? 149.347 192.112 178.952 1.00 36.73  ? 39  LEU B CB  1 
ATOM   5383 C CG  . LEU D 4 39  ? 150.265 192.516 177.792 1.00 36.73  ? 39  LEU B CG  1 
ATOM   5384 C CD1 . LEU D 4 39  ? 150.443 194.006 177.655 1.00 36.73  ? 39  LEU B CD1 1 
ATOM   5385 C CD2 . LEU D 4 39  ? 151.612 191.860 177.970 1.00 36.73  ? 39  LEU B CD2 1 
ATOM   5386 N N   . GLY D 4 40  ? 147.038 194.212 179.585 1.00 54.62  ? 40  GLY B N   1 
ATOM   5387 C CA  . GLY D 4 40  ? 146.423 195.511 179.424 1.00 54.62  ? 40  GLY B CA  1 
ATOM   5388 C C   . GLY D 4 40  ? 146.321 196.224 180.757 1.00 54.62  ? 40  GLY B C   1 
ATOM   5389 O O   . GLY D 4 40  ? 146.655 195.671 181.807 1.00 54.62  ? 40  GLY B O   1 
ATOM   5390 N N   . ALA D 4 41  ? 145.850 197.465 180.687 1.00 71.14  ? 41  ALA B N   1 
ATOM   5391 C CA  . ALA D 4 41  ? 145.703 198.282 181.880 1.00 71.14  ? 41  ALA B CA  1 
ATOM   5392 C C   . ALA D 4 41  ? 144.560 197.765 182.749 1.00 71.14  ? 41  ALA B C   1 
ATOM   5393 O O   . ALA D 4 41  ? 143.671 197.043 182.289 1.00 71.14  ? 41  ALA B O   1 
ATOM   5394 C CB  . ALA D 4 41  ? 145.458 199.743 181.502 1.00 71.14  ? 41  ALA B CB  1 
ATOM   5395 N N   . GLY D 4 42  ? 144.606 198.132 184.028 1.00 81.39  ? 42  GLY B N   1 
ATOM   5396 C CA  . GLY D 4 42  ? 143.544 197.755 184.939 1.00 81.39  ? 42  GLY B CA  1 
ATOM   5397 C C   . GLY D 4 42  ? 142.227 198.416 184.581 1.00 81.39  ? 42  GLY B C   1 
ATOM   5398 O O   . GLY D 4 42  ? 142.180 199.568 184.149 1.00 81.39  ? 42  GLY B O   1 
ATOM   5399 N N   . GLU D 4 43  ? 141.143 197.646 184.759 1.00 82.44  ? 43  GLU B N   1 
ATOM   5400 C CA  . GLU D 4 43  ? 139.749 197.953 184.416 1.00 82.44  ? 43  GLU B CA  1 
ATOM   5401 C C   . GLU D 4 43  ? 139.598 198.622 183.048 1.00 82.44  ? 43  GLU B C   1 
ATOM   5402 O O   . GLU D 4 43  ? 138.675 199.409 182.826 1.00 82.44  ? 43  GLU B O   1 
ATOM   5403 C CB  . GLU D 4 43  ? 139.075 198.764 185.551 1.00 82.44  ? 43  GLU B CB  1 
ATOM   5404 C CG  . GLU D 4 43  ? 139.620 200.153 185.944 1.00 82.44  ? 43  GLU B CG  1 
ATOM   5405 C CD  . GLU D 4 43  ? 138.948 201.316 185.230 1.00 82.44  ? 43  GLU B CD  1 
ATOM   5406 O OE1 . GLU D 4 43  ? 137.801 201.157 184.764 1.00 82.44  ? 43  GLU B OE1 1 
ATOM   5407 O OE2 . GLU D 4 43  ? 139.567 202.398 185.137 1.00 82.44  ? 43  GLU B OE2 1 
ATOM   5408 N N   . SER D 4 44  ? 140.466 198.257 182.099 1.00 68.71  ? 44  SER B N   1 
ATOM   5409 C CA  . SER D 4 44  ? 140.443 198.806 180.749 1.00 68.71  ? 44  SER B CA  1 
ATOM   5410 C C   . SER D 4 44  ? 139.747 197.882 179.759 1.00 68.71  ? 44  SER B C   1 
ATOM   5411 O O   . SER D 4 44  ? 140.177 197.777 178.602 1.00 68.71  ? 44  SER B O   1 
ATOM   5412 C CB  . SER D 4 44  ? 141.866 199.118 180.283 1.00 68.71  ? 44  SER B CB  1 
ATOM   5413 O OG  . SER D 4 44  ? 142.557 197.936 179.929 1.00 68.71  ? 44  SER B OG  1 
ATOM   5414 N N   . GLY D 4 45  ? 138.688 197.200 180.186 1.00 67.85  ? 45  GLY B N   1 
ATOM   5415 C CA  . GLY D 4 45  ? 137.976 196.281 179.326 1.00 67.85  ? 45  GLY B CA  1 
ATOM   5416 C C   . GLY D 4 45  ? 138.622 194.927 179.163 1.00 67.85  ? 45  GLY B C   1 
ATOM   5417 O O   . GLY D 4 45  ? 138.150 194.128 178.347 1.00 67.85  ? 45  GLY B O   1 
ATOM   5418 N N   . LYS D 4 46  ? 139.685 194.640 179.917 1.00 63.05  ? 46  LYS B N   1 
ATOM   5419 C CA  . LYS D 4 46  ? 140.343 193.343 179.813 1.00 63.05  ? 46  LYS B CA  1 
ATOM   5420 C C   . LYS D 4 46  ? 139.505 192.236 180.436 1.00 63.05  ? 46  LYS B C   1 
ATOM   5421 O O   . LYS D 4 46  ? 139.625 191.072 180.040 1.00 63.05  ? 46  LYS B O   1 
ATOM   5422 C CB  . LYS D 4 46  ? 141.714 193.403 180.480 1.00 63.05  ? 46  LYS B CB  1 
ATOM   5423 C CG  . LYS D 4 46  ? 142.678 192.325 180.036 1.00 63.05  ? 46  LYS B CG  1 
ATOM   5424 C CD  . LYS D 4 46  ? 144.107 192.723 180.353 1.00 63.05  ? 46  LYS B CD  1 
ATOM   5425 C CE  . LYS D 4 46  ? 144.297 192.921 181.849 1.00 63.05  ? 46  LYS B CE  1 
ATOM   5426 N NZ  . LYS D 4 46  ? 145.702 193.265 182.199 1.00 63.05  ? 46  LYS B NZ  1 
ATOM   5427 N N   . SER D 4 47  ? 138.652 192.578 181.404 1.00 68.94  ? 47  SER B N   1 
ATOM   5428 C CA  . SER D 4 47  ? 137.879 191.558 182.102 1.00 68.94  ? 47  SER B CA  1 
ATOM   5429 C C   . SER D 4 47  ? 136.735 191.023 181.251 1.00 68.94  ? 47  SER B C   1 
ATOM   5430 O O   . SER D 4 47  ? 136.337 189.864 181.413 1.00 68.94  ? 47  SER B O   1 
ATOM   5431 C CB  . SER D 4 47  ? 137.342 192.120 183.418 1.00 68.94  ? 47  SER B CB  1 
ATOM   5432 O OG  . SER D 4 47  ? 138.400 192.568 184.247 1.00 68.94  ? 47  SER B OG  1 
ATOM   5433 N N   . THR D 4 48  ? 136.189 191.838 180.353 1.00 75.70  ? 48  THR B N   1 
ATOM   5434 C CA  . THR D 4 48  ? 135.061 191.417 179.534 1.00 75.70  ? 48  THR B CA  1 
ATOM   5435 C C   . THR D 4 48  ? 135.481 190.758 178.228 1.00 75.70  ? 48  THR B C   1 
ATOM   5436 O O   . THR D 4 48  ? 134.627 190.202 177.530 1.00 75.70  ? 48  THR B O   1 
ATOM   5437 C CB  . THR D 4 48  ? 134.150 192.612 179.233 1.00 75.70  ? 48  THR B CB  1 
ATOM   5438 O OG1 . THR D 4 48  ? 132.896 192.142 178.723 1.00 75.70  ? 48  THR B OG1 1 
ATOM   5439 C CG2 . THR D 4 48  ? 134.795 193.536 178.211 1.00 75.70  ? 48  THR B CG2 1 
ATOM   5440 N N   . ILE D 4 49  ? 136.768 190.801 177.883 1.00 77.05  ? 49  ILE B N   1 
ATOM   5441 C CA  . ILE D 4 49  ? 137.232 190.160 176.657 1.00 77.05  ? 49  ILE B CA  1 
ATOM   5442 C C   . ILE D 4 49  ? 137.298 188.647 176.835 1.00 77.05  ? 49  ILE B C   1 
ATOM   5443 O O   . ILE D 4 49  ? 136.933 187.886 175.930 1.00 77.05  ? 49  ILE B O   1 
ATOM   5444 C CB  . ILE D 4 49  ? 138.587 190.763 176.237 1.00 77.05  ? 49  ILE B CB  1 
ATOM   5445 C CG1 . ILE D 4 49  ? 138.370 192.133 175.595 1.00 77.05  ? 49  ILE B CG1 1 
ATOM   5446 C CG2 . ILE D 4 49  ? 139.332 189.865 175.262 1.00 77.05  ? 49  ILE B CG2 1 
ATOM   5447 C CD1 . ILE D 4 49  ? 137.444 192.101 174.397 1.00 77.05  ? 49  ILE B CD1 1 
ATOM   5448 N N   . VAL D 4 50  ? 137.710 188.189 178.021 1.00 76.18  ? 50  VAL B N   1 
ATOM   5449 C CA  . VAL D 4 50  ? 137.967 186.772 178.256 1.00 76.18  ? 50  VAL B CA  1 
ATOM   5450 C C   . VAL D 4 50  ? 136.714 185.910 178.238 1.00 76.18  ? 50  VAL B C   1 
ATOM   5451 O O   . VAL D 4 50  ? 136.826 184.681 178.168 1.00 76.18  ? 50  VAL B O   1 
ATOM   5452 C CB  . VAL D 4 50  ? 138.697 186.578 179.600 1.00 76.18  ? 50  VAL B CB  1 
ATOM   5453 C CG1 . VAL D 4 50  ? 139.988 187.369 179.610 1.00 76.18  ? 50  VAL B CG1 1 
ATOM   5454 C CG2 . VAL D 4 50  ? 137.804 186.988 180.758 1.00 76.18  ? 50  VAL B CG2 1 
ATOM   5455 N N   . LYS D 4 51  ? 135.525 186.510 178.293 1.00 77.46  ? 51  LYS B N   1 
ATOM   5456 C CA  . LYS D 4 51  ? 134.298 185.732 178.199 1.00 77.46  ? 51  LYS B CA  1 
ATOM   5457 C C   . LYS D 4 51  ? 133.974 185.312 176.771 1.00 77.46  ? 51  LYS B C   1 
ATOM   5458 O O   . LYS D 4 51  ? 133.045 184.522 176.571 1.00 77.46  ? 51  LYS B O   1 
ATOM   5459 C CB  . LYS D 4 51  ? 133.128 186.517 178.800 1.00 77.46  ? 51  LYS B CB  1 
ATOM   5460 C CG  . LYS D 4 51  ? 132.576 187.624 177.922 1.00 77.46  ? 51  LYS B CG  1 
ATOM   5461 C CD  . LYS D 4 51  ? 131.571 188.463 178.698 1.00 77.46  ? 51  LYS B CD  1 
ATOM   5462 C CE  . LYS D 4 51  ? 130.937 189.533 177.828 1.00 77.46  ? 51  LYS B CE  1 
ATOM   5463 N NZ  . LYS D 4 51  ? 129.930 188.958 176.894 1.00 77.46  ? 51  LYS B NZ  1 
ATOM   5464 N N   . GLN D 4 52  ? 134.708 185.817 175.784 1.00 76.62  ? 52  GLN B N   1 
ATOM   5465 C CA  . GLN D 4 52  ? 134.591 185.337 174.413 1.00 76.62  ? 52  GLN B CA  1 
ATOM   5466 C C   . GLN D 4 52  ? 135.740 184.387 174.090 1.00 76.62  ? 52  GLN B C   1 
ATOM   5467 O O   . GLN D 4 52  ? 136.873 184.603 174.520 1.00 76.62  ? 52  GLN B O   1 
ATOM   5468 C CB  . GLN D 4 52  ? 134.577 186.501 173.419 1.00 76.62  ? 52  GLN B CB  1 
ATOM   5469 C CG  . GLN D 4 52  ? 133.285 187.299 173.397 1.00 76.62  ? 52  GLN B CG  1 
ATOM   5470 C CD  . GLN D 4 52  ? 133.257 188.395 174.440 1.00 76.62  ? 52  GLN B CD  1 
ATOM   5471 O OE1 . GLN D 4 52  ? 134.289 188.761 175.001 1.00 76.62  ? 52  GLN B OE1 1 
ATOM   5472 N NE2 . GLN D 4 52  ? 132.073 188.934 174.698 1.00 76.62  ? 52  GLN B NE2 1 
ATOM   5473 N N   . LYS D 4 180 ? 142.658 179.361 193.064 1.00 88.66  ? 180 LYS B N   1 
ATOM   5474 C CA  . LYS D 4 180 ? 143.171 180.671 193.446 1.00 88.66  ? 180 LYS B CA  1 
ATOM   5475 C C   . LYS D 4 180 ? 144.697 180.675 193.470 1.00 88.66  ? 180 LYS B C   1 
ATOM   5476 O O   . LYS D 4 180 ? 145.314 180.187 194.417 1.00 88.66  ? 180 LYS B O   1 
ATOM   5477 C CB  . LYS D 4 180 ? 142.620 181.084 194.812 1.00 88.66  ? 180 LYS B CB  1 
ATOM   5478 N N   . THR D 4 181 ? 145.302 181.233 192.420 1.00 89.19  ? 181 THR B N   1 
ATOM   5479 C CA  . THR D 4 181 ? 146.752 181.286 192.306 1.00 89.19  ? 181 THR B CA  1 
ATOM   5480 C C   . THR D 4 181 ? 147.332 182.684 192.453 1.00 89.19  ? 181 THR B C   1 
ATOM   5481 O O   . THR D 4 181 ? 148.528 182.802 192.741 1.00 89.19  ? 181 THR B O   1 
ATOM   5482 C CB  . THR D 4 181 ? 147.207 180.700 190.960 1.00 89.19  ? 181 THR B CB  1 
ATOM   5483 O OG1 . THR D 4 181 ? 148.637 180.734 190.880 1.00 89.19  ? 181 THR B OG1 1 
ATOM   5484 C CG2 . THR D 4 181 ? 146.616 181.483 189.798 1.00 89.19  ? 181 THR B CG2 1 
ATOM   5485 N N   . THR D 4 182 ? 146.515 183.731 192.270 1.00 85.37  ? 182 THR B N   1 
ATOM   5486 C CA  . THR D 4 182 ? 146.926 185.140 192.368 1.00 85.37  ? 182 THR B CA  1 
ATOM   5487 C C   . THR D 4 182 ? 148.112 185.453 191.457 1.00 85.37  ? 182 THR B C   1 
ATOM   5488 O O   . THR D 4 182 ? 148.999 186.238 191.799 1.00 85.37  ? 182 THR B O   1 
ATOM   5489 C CB  . THR D 4 182 ? 147.231 185.542 193.816 1.00 85.37  ? 182 THR B CB  1 
ATOM   5490 O OG1 . THR D 4 182 ? 148.479 184.967 194.227 1.00 85.37  ? 182 THR B OG1 1 
ATOM   5491 C CG2 . THR D 4 182 ? 146.121 185.076 194.750 1.00 85.37  ? 182 THR B CG2 1 
ATOM   5492 N N   . GLY D 4 183 ? 148.125 184.832 190.281 1.00 76.57  ? 183 GLY B N   1 
ATOM   5493 C CA  . GLY D 4 183 ? 149.190 185.038 189.321 1.00 76.57  ? 183 GLY B CA  1 
ATOM   5494 C C   . GLY D 4 183 ? 148.673 185.100 187.901 1.00 76.57  ? 183 GLY B C   1 
ATOM   5495 O O   . GLY D 4 183 ? 147.726 185.836 187.611 1.00 76.57  ? 183 GLY B O   1 
ATOM   5496 N N   . ILE D 4 184 ? 149.279 184.330 187.002 1.00 67.06  ? 184 ILE B N   1 
ATOM   5497 C CA  . ILE D 4 184 ? 148.802 184.294 185.626 1.00 67.06  ? 184 ILE B CA  1 
ATOM   5498 C C   . ILE D 4 184 ? 147.567 183.408 185.550 1.00 67.06  ? 184 ILE B C   1 
ATOM   5499 O O   . ILE D 4 184 ? 147.613 182.220 185.890 1.00 67.06  ? 184 ILE B O   1 
ATOM   5500 C CB  . ILE D 4 184 ? 149.898 183.807 184.675 1.00 67.06  ? 184 ILE B CB  1 
ATOM   5501 C CG1 . ILE D 4 184 ? 151.011 184.844 184.588 1.00 67.06  ? 184 ILE B CG1 1 
ATOM   5502 C CG2 . ILE D 4 184 ? 149.322 183.527 183.300 1.00 67.06  ? 184 ILE B CG2 1 
ATOM   5503 C CD1 . ILE D 4 184 ? 152.157 184.398 183.744 1.00 67.06  ? 184 ILE B CD1 1 
ATOM   5504 N N   . VAL D 4 185 ? 146.458 183.985 185.102 1.00 65.26  ? 185 VAL B N   1 
ATOM   5505 C CA  . VAL D 4 185 ? 145.211 183.248 184.944 1.00 65.26  ? 185 VAL B CA  1 
ATOM   5506 C C   . VAL D 4 185 ? 145.242 182.532 183.600 1.00 65.26  ? 185 VAL B C   1 
ATOM   5507 O O   . VAL D 4 185 ? 145.543 183.141 182.568 1.00 65.26  ? 185 VAL B O   1 
ATOM   5508 C CB  . VAL D 4 185 ? 144.001 184.184 185.049 1.00 65.26  ? 185 VAL B CB  1 
ATOM   5509 C CG1 . VAL D 4 185 ? 142.709 183.386 185.045 1.00 65.26  ? 185 VAL B CG1 1 
ATOM   5510 C CG2 . VAL D 4 185 ? 144.104 185.036 186.303 1.00 65.26  ? 185 VAL B CG2 1 
ATOM   5511 N N   . GLU D 4 186 ? 144.943 181.238 183.610 1.00 69.23  ? 186 GLU B N   1 
ATOM   5512 C CA  . GLU D 4 186 ? 144.961 180.417 182.407 1.00 69.23  ? 186 GLU B CA  1 
ATOM   5513 C C   . GLU D 4 186 ? 143.537 180.208 181.912 1.00 69.23  ? 186 GLU B C   1 
ATOM   5514 O O   . GLU D 4 186 ? 142.685 179.705 182.652 1.00 69.23  ? 186 GLU B O   1 
ATOM   5515 C CB  . GLU D 4 186 ? 145.632 179.071 182.677 1.00 69.23  ? 186 GLU B CB  1 
ATOM   5516 C CG  . GLU D 4 186 ? 147.101 179.169 183.027 1.00 69.23  ? 186 GLU B CG  1 
ATOM   5517 C CD  . GLU D 4 186 ? 147.968 179.402 181.810 1.00 69.23  ? 186 GLU B CD  1 
ATOM   5518 O OE1 . GLU D 4 186 ? 147.562 178.984 180.705 1.00 69.23  ? 186 GLU B OE1 1 
ATOM   5519 O OE2 . GLU D 4 186 ? 149.054 179.998 181.958 1.00 69.23  ? 186 GLU B OE2 1 
ATOM   5520 N N   . THR D 4 187 ? 143.282 180.595 180.665 1.00 65.75  ? 187 THR B N   1 
ATOM   5521 C CA  . THR D 4 187 ? 142.006 180.355 180.006 1.00 65.75  ? 187 THR B CA  1 
ATOM   5522 C C   . THR D 4 187 ? 142.247 179.520 178.757 1.00 65.75  ? 187 THR B C   1 
ATOM   5523 O O   . THR D 4 187 ? 143.062 179.890 177.906 1.00 65.75  ? 187 THR B O   1 
ATOM   5524 C CB  . THR D 4 187 ? 141.308 181.667 179.643 1.00 65.75  ? 187 THR B CB  1 
ATOM   5525 O OG1 . THR D 4 187 ? 142.184 182.469 178.843 1.00 65.75  ? 187 THR B OG1 1 
ATOM   5526 C CG2 . THR D 4 187 ? 140.932 182.437 180.900 1.00 65.75  ? 187 THR B CG2 1 
ATOM   5527 N N   . HIS D 4 188 ? 141.541 178.399 178.654 1.00 68.29  ? 188 HIS B N   1 
ATOM   5528 C CA  . HIS D 4 188 ? 141.673 177.481 177.530 1.00 68.29  ? 188 HIS B CA  1 
ATOM   5529 C C   . HIS D 4 188 ? 140.415 177.565 176.679 1.00 68.29  ? 188 HIS B C   1 
ATOM   5530 O O   . HIS D 4 188 ? 139.326 177.201 177.138 1.00 68.29  ? 188 HIS B O   1 
ATOM   5531 C CB  . HIS D 4 188 ? 141.895 176.050 178.018 1.00 68.29  ? 188 HIS B CB  1 
ATOM   5532 C CG  . HIS D 4 188 ? 143.182 175.855 178.756 1.00 68.29  ? 188 HIS B CG  1 
ATOM   5533 N ND1 . HIS D 4 188 ? 144.413 176.067 178.175 1.00 68.29  ? 188 HIS B ND1 1 
ATOM   5534 C CD2 . HIS D 4 188 ? 143.428 175.466 180.029 1.00 68.29  ? 188 HIS B CD2 1 
ATOM   5535 C CE1 . HIS D 4 188 ? 145.363 175.818 179.059 1.00 68.29  ? 188 HIS B CE1 1 
ATOM   5536 N NE2 . HIS D 4 188 ? 144.792 175.452 180.192 1.00 68.29  ? 188 HIS B NE2 1 
ATOM   5537 N N   . PHE D 4 189 ? 140.566 178.037 175.445 1.00 63.35  ? 189 PHE B N   1 
ATOM   5538 C CA  . PHE D 4 189 ? 139.444 178.151 174.527 1.00 63.35  ? 189 PHE B CA  1 
ATOM   5539 C C   . PHE D 4 189 ? 139.947 177.910 173.114 1.00 63.35  ? 189 PHE B C   1 
ATOM   5540 O O   . PHE D 4 189 ? 141.134 178.077 172.827 1.00 63.35  ? 189 PHE B O   1 
ATOM   5541 C CB  . PHE D 4 189 ? 138.762 179.520 174.627 1.00 63.35  ? 189 PHE B CB  1 
ATOM   5542 C CG  . PHE D 4 189 ? 139.511 180.627 173.939 1.00 63.35  ? 189 PHE B CG  1 
ATOM   5543 C CD1 . PHE D 4 189 ? 140.662 181.155 174.497 1.00 63.35  ? 189 PHE B CD1 1 
ATOM   5544 C CD2 . PHE D 4 189 ? 139.049 181.154 172.743 1.00 63.35  ? 189 PHE B CD2 1 
ATOM   5545 C CE1 . PHE D 4 189 ? 141.345 182.175 173.870 1.00 63.35  ? 189 PHE B CE1 1 
ATOM   5546 C CE2 . PHE D 4 189 ? 139.731 182.173 172.111 1.00 63.35  ? 189 PHE B CE2 1 
ATOM   5547 C CZ  . PHE D 4 189 ? 140.880 182.685 172.677 1.00 63.35  ? 189 PHE B CZ  1 
ATOM   5548 N N   . THR D 4 190 ? 139.031 177.522 172.234 1.00 62.63  ? 190 THR B N   1 
ATOM   5549 C CA  . THR D 4 190 ? 139.375 177.188 170.862 1.00 62.63  ? 190 THR B CA  1 
ATOM   5550 C C   . THR D 4 190 ? 138.366 177.796 169.900 1.00 62.63  ? 190 THR B C   1 
ATOM   5551 O O   . THR D 4 190 ? 137.212 178.051 170.256 1.00 62.63  ? 190 THR B O   1 
ATOM   5552 C CB  . THR D 4 190 ? 139.433 175.672 170.656 1.00 62.63  ? 190 THR B CB  1 
ATOM   5553 O OG1 . THR D 4 190 ? 139.654 175.383 169.271 1.00 62.63  ? 190 THR B OG1 1 
ATOM   5554 C CG2 . THR D 4 190 ? 138.138 175.012 171.115 1.00 62.63  ? 190 THR B CG2 1 
ATOM   5555 N N   . PHE D 4 191 ? 138.822 178.033 168.673 1.00 61.03  ? 191 PHE B N   1 
ATOM   5556 C CA  . PHE D 4 191 ? 137.946 178.467 167.591 1.00 61.03  ? 191 PHE B CA  1 
ATOM   5557 C C   . PHE D 4 191 ? 138.463 177.868 166.296 1.00 61.03  ? 191 PHE B C   1 
ATOM   5558 O O   . PHE D 4 191 ? 139.619 178.107 165.929 1.00 61.03  ? 191 PHE B O   1 
ATOM   5559 C CB  . PHE D 4 191 ? 137.882 179.991 167.494 1.00 61.03  ? 191 PHE B CB  1 
ATOM   5560 C CG  . PHE D 4 191 ? 136.778 180.493 166.602 1.00 61.03  ? 191 PHE B CG  1 
ATOM   5561 C CD1 . PHE D 4 191 ? 135.545 179.860 166.581 1.00 61.03  ? 191 PHE B CD1 1 
ATOM   5562 C CD2 . PHE D 4 191 ? 136.978 181.591 165.778 1.00 61.03  ? 191 PHE B CD2 1 
ATOM   5563 C CE1 . PHE D 4 191 ? 134.530 180.317 165.758 1.00 61.03  ? 191 PHE B CE1 1 
ATOM   5564 C CE2 . PHE D 4 191 ? 135.967 182.052 164.954 1.00 61.03  ? 191 PHE B CE2 1 
ATOM   5565 C CZ  . PHE D 4 191 ? 134.742 181.414 164.944 1.00 61.03  ? 191 PHE B CZ  1 
ATOM   5566 N N   . LYS D 4 192 ? 137.602 177.099 165.622 1.00 58.88  ? 192 LYS B N   1 
ATOM   5567 C CA  . LYS D 4 192 ? 137.923 176.413 164.367 1.00 58.88  ? 192 LYS B CA  1 
ATOM   5568 C C   . LYS D 4 192 ? 139.129 175.489 164.526 1.00 58.88  ? 192 LYS B C   1 
ATOM   5569 O O   . LYS D 4 192 ? 139.990 175.412 163.646 1.00 58.88  ? 192 LYS B O   1 
ATOM   5570 C CB  . LYS D 4 192 ? 138.140 177.411 163.227 1.00 58.88  ? 192 LYS B CB  1 
ATOM   5571 C CG  . LYS D 4 192 ? 136.962 178.343 162.994 1.00 58.88  ? 192 LYS B CG  1 
ATOM   5572 C CD  . LYS D 4 192 ? 135.754 177.600 162.451 1.00 58.88  ? 192 LYS B CD  1 
ATOM   5573 C CE  . LYS D 4 192 ? 134.574 178.542 162.269 1.00 58.88  ? 192 LYS B CE  1 
ATOM   5574 N NZ  . LYS D 4 192 ? 134.825 179.548 161.199 1.00 58.88  ? 192 LYS B NZ  1 
ATOM   5575 N N   . ASP D 4 193 ? 139.181 174.794 165.667 1.00 64.25  ? 193 ASP B N   1 
ATOM   5576 C CA  . ASP D 4 193 ? 140.191 173.780 165.985 1.00 64.25  ? 193 ASP B CA  1 
ATOM   5577 C C   . ASP D 4 193 ? 141.608 174.360 165.948 1.00 64.25  ? 193 ASP B C   1 
ATOM   5578 O O   . ASP D 4 193 ? 142.433 174.010 165.102 1.00 64.25  ? 193 ASP B O   1 
ATOM   5579 C CB  . ASP D 4 193 ? 140.060 172.564 165.057 1.00 64.25  ? 193 ASP B CB  1 
ATOM   5580 C CG  . ASP D 4 193 ? 140.740 171.326 165.613 1.00 64.25  ? 193 ASP B CG  1 
ATOM   5581 O OD1 . ASP D 4 193 ? 141.266 171.385 166.745 1.00 64.25  ? 193 ASP B OD1 1 
ATOM   5582 O OD2 . ASP D 4 193 ? 140.745 170.288 164.917 1.00 64.25  ? 193 ASP B OD2 1 
ATOM   5583 N N   . LEU D 4 194 ? 141.875 175.273 166.882 1.00 61.80  ? 194 LEU B N   1 
ATOM   5584 C CA  . LEU D 4 194 ? 143.202 175.862 167.014 1.00 61.80  ? 194 LEU B CA  1 
ATOM   5585 C C   . LEU D 4 194 ? 143.736 175.898 168.443 1.00 61.80  ? 194 LEU B C   1 
ATOM   5586 O O   . LEU D 4 194 ? 144.962 175.958 168.611 1.00 61.80  ? 194 LEU B O   1 
ATOM   5587 C CB  . LEU D 4 194 ? 143.212 177.282 166.427 1.00 61.80  ? 194 LEU B CB  1 
ATOM   5588 C CG  . LEU D 4 194 ? 144.564 177.895 166.065 1.00 61.80  ? 194 LEU B CG  1 
ATOM   5589 C CD1 . LEU D 4 194 ? 145.402 176.902 165.297 1.00 61.80  ? 194 LEU B CD1 1 
ATOM   5590 C CD2 . LEU D 4 194 ? 144.334 179.121 165.228 1.00 61.80  ? 194 LEU B CD2 1 
ATOM   5591 N N   . HIS D 4 195 ? 142.874 175.840 169.464 1.00 66.36  ? 195 HIS B N   1 
ATOM   5592 C CA  . HIS D 4 195 ? 143.253 175.669 170.872 1.00 66.36  ? 195 HIS B CA  1 
ATOM   5593 C C   . HIS D 4 195 ? 144.155 176.810 171.359 1.00 66.36  ? 195 HIS B C   1 
ATOM   5594 O O   . HIS D 4 195 ? 145.339 176.631 171.651 1.00 66.36  ? 195 HIS B O   1 
ATOM   5595 C CB  . HIS D 4 195 ? 143.923 174.307 171.102 1.00 66.36  ? 195 HIS B CB  1 
ATOM   5596 C CG  . HIS D 4 195 ? 143.065 173.135 170.743 1.00 66.36  ? 195 HIS B CG  1 
ATOM   5597 N ND1 . HIS D 4 195 ? 141.699 173.229 170.587 1.00 66.36  ? 195 HIS B ND1 1 
ATOM   5598 C CD2 . HIS D 4 195 ? 143.380 171.840 170.505 1.00 66.36  ? 195 HIS B CD2 1 
ATOM   5599 C CE1 . HIS D 4 195 ? 141.209 172.044 170.271 1.00 66.36  ? 195 HIS B CE1 1 
ATOM   5600 N NE2 . HIS D 4 195 ? 142.209 171.183 170.215 1.00 66.36  ? 195 HIS B NE2 1 
ATOM   5601 N N   . PHE D 4 196 ? 143.563 178.000 171.417 1.00 62.37  ? 196 PHE B N   1 
ATOM   5602 C CA  . PHE D 4 196 ? 144.266 179.165 171.935 1.00 62.37  ? 196 PHE B CA  1 
ATOM   5603 C C   . PHE D 4 196 ? 144.496 179.043 173.441 1.00 62.37  ? 196 PHE B C   1 
ATOM   5604 O O   . PHE D 4 196 ? 143.742 178.385 174.163 1.00 62.37  ? 196 PHE B O   1 
ATOM   5605 C CB  . PHE D 4 196 ? 143.482 180.446 171.659 1.00 62.37  ? 196 PHE B CB  1 
ATOM   5606 C CG  . PHE D 4 196 ? 143.060 180.614 170.231 1.00 62.37  ? 196 PHE B CG  1 
ATOM   5607 C CD1 . PHE D 4 196 ? 143.903 181.215 169.315 1.00 62.37  ? 196 PHE B CD1 1 
ATOM   5608 C CD2 . PHE D 4 196 ? 141.807 180.198 169.812 1.00 62.37  ? 196 PHE B CD2 1 
ATOM   5609 C CE1 . PHE D 4 196 ? 143.515 181.378 168.006 1.00 62.37  ? 196 PHE B CE1 1 
ATOM   5610 C CE2 . PHE D 4 196 ? 141.412 180.359 168.500 1.00 62.37  ? 196 PHE B CE2 1 
ATOM   5611 C CZ  . PHE D 4 196 ? 142.268 180.952 167.598 1.00 62.37  ? 196 PHE B CZ  1 
ATOM   5612 N N   . LYS D 4 197 ? 145.555 179.698 173.914 1.00 62.84  ? 197 LYS B N   1 
ATOM   5613 C CA  . LYS D 4 197 ? 145.778 179.885 175.343 1.00 62.84  ? 197 LYS B CA  1 
ATOM   5614 C C   . LYS D 4 197 ? 146.076 181.350 175.605 1.00 62.84  ? 197 LYS B C   1 
ATOM   5615 O O   . LYS D 4 197 ? 146.890 181.950 174.900 1.00 62.84  ? 197 LYS B O   1 
ATOM   5616 C CB  . LYS D 4 197 ? 146.937 179.029 175.866 1.00 62.84  ? 197 LYS B CB  1 
ATOM   5617 C CG  . LYS D 4 197 ? 146.691 177.535 175.859 1.00 62.84  ? 197 LYS B CG  1 
ATOM   5618 C CD  . LYS D 4 197 ? 147.752 176.821 176.685 1.00 62.84  ? 197 LYS B CD  1 
ATOM   5619 C CE  . LYS D 4 197 ? 149.125 176.930 176.048 1.00 62.84  ? 197 LYS B CE  1 
ATOM   5620 N NZ  . LYS D 4 197 ? 150.144 176.147 176.797 1.00 62.84  ? 197 LYS B NZ  1 
ATOM   5621 N N   . MET D 4 198 ? 145.428 181.924 176.615 1.00 60.68  ? 198 MET B N   1 
ATOM   5622 C CA  . MET D 4 198 ? 145.652 183.310 177.001 1.00 60.68  ? 198 MET B CA  1 
ATOM   5623 C C   . MET D 4 198 ? 146.276 183.358 178.388 1.00 60.68  ? 198 MET B C   1 
ATOM   5624 O O   . MET D 4 198 ? 145.835 182.647 179.297 1.00 60.68  ? 198 MET B O   1 
ATOM   5625 C CB  . MET D 4 198 ? 144.351 184.114 176.981 1.00 60.68  ? 198 MET B CB  1 
ATOM   5626 C CG  . MET D 4 198 ? 143.760 184.314 175.598 1.00 60.68  ? 198 MET B CG  1 
ATOM   5627 S SD  . MET D 4 198 ? 142.438 185.537 175.591 1.00 60.68  ? 198 MET B SD  1 
ATOM   5628 C CE  . MET D 4 198 ? 141.148 184.661 176.471 1.00 60.68  ? 198 MET B CE  1 
ATOM   5629 N N   . PHE D 4 199 ? 147.294 184.198 178.544 1.00 55.70  ? 199 PHE B N   1 
ATOM   5630 C CA  . PHE D 4 199 ? 148.019 184.351 179.803 1.00 55.70  ? 199 PHE B CA  1 
ATOM   5631 C C   . PHE D 4 199 ? 147.773 185.761 180.329 1.00 55.70  ? 199 PHE B C   1 
ATOM   5632 O O   . PHE D 4 199 ? 148.572 186.671 180.105 1.00 55.70  ? 199 PHE B O   1 
ATOM   5633 C CB  . PHE D 4 199 ? 149.504 184.093 179.608 1.00 55.70  ? 199 PHE B CB  1 
ATOM   5634 C CG  . PHE D 4 199 ? 149.805 182.833 178.860 1.00 55.70  ? 199 PHE B CG  1 
ATOM   5635 C CD1 . PHE D 4 199 ? 149.211 181.638 179.228 1.00 55.70  ? 199 PHE B CD1 1 
ATOM   5636 C CD2 . PHE D 4 199 ? 150.687 182.840 177.795 1.00 55.70  ? 199 PHE B CD2 1 
ATOM   5637 C CE1 . PHE D 4 199 ? 149.487 180.472 178.546 1.00 55.70  ? 199 PHE B CE1 1 
ATOM   5638 C CE2 . PHE D 4 199 ? 150.969 181.678 177.108 1.00 55.70  ? 199 PHE B CE2 1 
ATOM   5639 C CZ  . PHE D 4 199 ? 150.367 180.491 177.484 1.00 55.70  ? 199 PHE B CZ  1 
ATOM   5640 N N   . ASP D 4 200 ? 146.669 185.931 181.050 1.00 63.11  ? 200 ASP B N   1 
ATOM   5641 C CA  . ASP D 4 200 ? 146.363 187.216 181.662 1.00 63.11  ? 200 ASP B CA  1 
ATOM   5642 C C   . ASP D 4 200 ? 147.299 187.443 182.840 1.00 63.11  ? 200 ASP B C   1 
ATOM   5643 O O   . ASP D 4 200 ? 147.333 186.641 183.779 1.00 63.11  ? 200 ASP B O   1 
ATOM   5644 C CB  . ASP D 4 200 ? 144.902 187.255 182.107 1.00 63.11  ? 200 ASP B CB  1 
ATOM   5645 C CG  . ASP D 4 200 ? 144.434 188.655 182.455 1.00 63.11  ? 200 ASP B CG  1 
ATOM   5646 O OD1 . ASP D 4 200 ? 145.137 189.624 182.103 1.00 63.11  ? 200 ASP B OD1 1 
ATOM   5647 O OD2 . ASP D 4 200 ? 143.355 188.787 183.067 1.00 63.11  ? 200 ASP B OD2 1 
ATOM   5648 N N   . VAL D 4 201 ? 148.055 188.536 182.796 1.00 72.16  ? 201 VAL B N   1 
ATOM   5649 C CA  . VAL D 4 201 ? 149.083 188.797 183.795 1.00 72.16  ? 201 VAL B CA  1 
ATOM   5650 C C   . VAL D 4 201 ? 148.587 189.871 184.751 1.00 72.16  ? 201 VAL B C   1 
ATOM   5651 O O   . VAL D 4 201 ? 149.380 190.633 185.317 1.00 72.16  ? 201 VAL B O   1 
ATOM   5652 C CB  . VAL D 4 201 ? 150.409 189.212 183.133 1.00 72.16  ? 201 VAL B CB  1 
ATOM   5653 C CG1 . VAL D 4 201 ? 151.074 188.012 182.491 1.00 72.16  ? 201 VAL B CG1 1 
ATOM   5654 C CG2 . VAL D 4 201 ? 150.167 190.296 182.105 1.00 72.16  ? 201 VAL B CG2 1 
ATOM   5655 N N   . GLY D 4 202 ? 147.267 189.937 184.936 1.00 77.99  ? 202 GLY B N   1 
ATOM   5656 C CA  . GLY D 4 202 ? 146.670 190.989 185.739 1.00 77.99  ? 202 GLY B CA  1 
ATOM   5657 C C   . GLY D 4 202 ? 146.952 190.890 187.223 1.00 77.99  ? 202 GLY B C   1 
ATOM   5658 O O   . GLY D 4 202 ? 146.877 191.904 187.924 1.00 77.99  ? 202 GLY B O   1 
ATOM   5659 N N   . GLY D 4 203 ? 147.272 189.700 187.721 1.00 81.87  ? 203 GLY B N   1 
ATOM   5660 C CA  . GLY D 4 203 ? 147.537 189.519 189.141 1.00 81.87  ? 203 GLY B CA  1 
ATOM   5661 C C   . GLY D 4 203 ? 149.023 189.473 189.474 1.00 81.87  ? 203 GLY B C   1 
ATOM   5662 O O   . GLY D 4 203 ? 149.377 189.118 190.603 1.00 81.87  ? 203 GLY B O   1 
ATOM   5663 N N   . GLN D 4 204 ? 149.897 189.815 188.530 1.00 79.06  ? 204 GLN B N   1 
ATOM   5664 C CA  . GLN D 4 204 ? 151.342 189.794 188.751 1.00 79.06  ? 204 GLN B CA  1 
ATOM   5665 C C   . GLN D 4 204 ? 151.796 191.222 189.033 1.00 79.06  ? 204 GLN B C   1 
ATOM   5666 O O   . GLN D 4 204 ? 151.901 192.044 188.120 1.00 79.06  ? 204 GLN B O   1 
ATOM   5667 C CB  . GLN D 4 204 ? 152.067 189.204 187.547 1.00 79.06  ? 204 GLN B CB  1 
ATOM   5668 C CG  . GLN D 4 204 ? 153.490 188.784 187.838 1.00 79.06  ? 204 GLN B CG  1 
ATOM   5669 C CD  . GLN D 4 204 ? 153.550 187.550 188.713 1.00 79.06  ? 204 GLN B CD  1 
ATOM   5670 O OE1 . GLN D 4 204 ? 154.394 187.445 189.602 1.00 79.06  ? 204 GLN B OE1 1 
ATOM   5671 N NE2 . GLN D 4 204 ? 152.650 186.606 188.465 1.00 79.06  ? 204 GLN B NE2 1 
ATOM   5672 N N   . ARG D 4 205 ? 152.074 191.513 190.302 1.00 81.03  ? 205 ARG B N   1 
ATOM   5673 C CA  . ARG D 4 205 ? 152.447 192.849 190.741 1.00 81.03  ? 205 ARG B CA  1 
ATOM   5674 C C   . ARG D 4 205 ? 153.954 193.074 190.742 1.00 81.03  ? 205 ARG B C   1 
ATOM   5675 O O   . ARG D 4 205 ? 154.410 194.142 191.163 1.00 81.03  ? 205 ARG B O   1 
ATOM   5676 C CB  . ARG D 4 205 ? 151.881 193.120 192.136 1.00 81.03  ? 205 ARG B CB  1 
ATOM   5677 N N   . SER D 4 206 ? 154.733 192.104 190.274 1.00 79.54  ? 206 SER B N   1 
ATOM   5678 C CA  . SER D 4 206 ? 156.186 192.182 190.342 1.00 79.54  ? 206 SER B CA  1 
ATOM   5679 C C   . SER D 4 206 ? 156.726 193.009 189.176 1.00 79.54  ? 206 SER B C   1 
ATOM   5680 O O   . SER D 4 206 ? 155.976 193.625 188.414 1.00 79.54  ? 206 SER B O   1 
ATOM   5681 C CB  . SER D 4 206 ? 156.783 190.779 190.366 1.00 79.54  ? 206 SER B CB  1 
ATOM   5682 O OG  . SER D 4 206 ? 156.404 190.048 189.213 1.00 79.54  ? 206 SER B OG  1 
ATOM   5683 N N   . GLU D 4 207 ? 158.049 193.029 189.030 1.00 80.00  ? 207 GLU B N   1 
ATOM   5684 C CA  . GLU D 4 207 ? 158.688 193.809 187.977 1.00 80.00  ? 207 GLU B CA  1 
ATOM   5685 C C   . GLU D 4 207 ? 158.611 193.057 186.654 1.00 80.00  ? 207 GLU B C   1 
ATOM   5686 O O   . GLU D 4 207 ? 159.123 191.940 186.540 1.00 80.00  ? 207 GLU B O   1 
ATOM   5687 C CB  . GLU D 4 207 ? 160.139 194.104 188.348 1.00 80.00  ? 207 GLU B CB  1 
ATOM   5688 C CG  . GLU D 4 207 ? 160.745 195.268 187.583 1.00 80.00  ? 207 GLU B CG  1 
ATOM   5689 C CD  . GLU D 4 207 ? 162.089 195.691 188.137 1.00 80.00  ? 207 GLU B CD  1 
ATOM   5690 O OE1 . GLU D 4 207 ? 162.189 195.892 189.365 1.00 80.00  ? 207 GLU B OE1 1 
ATOM   5691 O OE2 . GLU D 4 207 ? 163.046 195.822 187.346 1.00 80.00  ? 207 GLU B OE2 1 
ATOM   5692 N N   . ARG D 4 208 ? 157.995 193.687 185.649 1.00 72.96  ? 208 ARG B N   1 
ATOM   5693 C CA  . ARG D 4 208 ? 157.682 193.021 184.389 1.00 72.96  ? 208 ARG B CA  1 
ATOM   5694 C C   . ARG D 4 208 ? 158.922 192.652 183.583 1.00 72.96  ? 208 ARG B C   1 
ATOM   5695 O O   . ARG D 4 208 ? 158.872 191.693 182.805 1.00 72.96  ? 208 ARG B O   1 
ATOM   5696 C CB  . ARG D 4 208 ? 156.749 193.912 183.557 1.00 72.96  ? 208 ARG B CB  1 
ATOM   5697 C CG  . ARG D 4 208 ? 156.182 193.266 182.294 1.00 72.96  ? 208 ARG B CG  1 
ATOM   5698 C CD  . ARG D 4 208 ? 155.178 194.161 181.594 1.00 72.96  ? 208 ARG B CD  1 
ATOM   5699 N NE  . ARG D 4 208 ? 153.950 194.305 182.364 1.00 72.96  ? 208 ARG B NE  1 
ATOM   5700 C CZ  . ARG D 4 208 ? 153.545 195.434 182.928 1.00 72.96  ? 208 ARG B CZ  1 
ATOM   5701 N NH1 . ARG D 4 208 ? 154.255 196.546 182.835 1.00 72.96  ? 208 ARG B NH1 1 
ATOM   5702 N NH2 . ARG D 4 208 ? 152.398 195.448 183.602 1.00 72.96  ? 208 ARG B NH2 1 
ATOM   5703 N N   . LYS D 4 209 ? 160.035 193.367 183.769 1.00 70.00  ? 209 LYS B N   1 
ATOM   5704 C CA  . LYS D 4 209 ? 161.212 193.154 182.930 1.00 70.00  ? 209 LYS B CA  1 
ATOM   5705 C C   . LYS D 4 209 ? 161.824 191.768 183.111 1.00 70.00  ? 209 LYS B C   1 
ATOM   5706 O O   . LYS D 4 209 ? 162.349 191.198 182.148 1.00 70.00  ? 209 LYS B O   1 
ATOM   5707 C CB  . LYS D 4 209 ? 162.267 194.218 183.224 1.00 70.00  ? 209 LYS B CB  1 
ATOM   5708 C CG  . LYS D 4 209 ? 163.315 194.351 182.134 1.00 70.00  ? 209 LYS B CG  1 
ATOM   5709 C CD  . LYS D 4 209 ? 164.270 195.490 182.421 1.00 70.00  ? 209 LYS B CD  1 
ATOM   5710 C CE  . LYS D 4 209 ? 165.220 195.122 183.545 1.00 70.00  ? 209 LYS B CE  1 
ATOM   5711 N NZ  . LYS D 4 209 ? 166.153 194.041 183.129 1.00 70.00  ? 209 LYS B NZ  1 
ATOM   5712 N N   . LYS D 4 210 ? 161.762 191.205 184.314 1.00 66.14  ? 210 LYS B N   1 
ATOM   5713 C CA  . LYS D 4 210 ? 162.476 189.971 184.606 1.00 66.14  ? 210 LYS B CA  1 
ATOM   5714 C C   . LYS D 4 210 ? 161.662 188.712 184.347 1.00 66.14  ? 210 LYS B C   1 
ATOM   5715 O O   . LYS D 4 210 ? 162.213 187.613 184.449 1.00 66.14  ? 210 LYS B O   1 
ATOM   5716 C CB  . LYS D 4 210 ? 162.970 189.974 186.055 1.00 66.14  ? 210 LYS B CB  1 
ATOM   5717 C CG  . LYS D 4 210 ? 163.928 191.107 186.387 1.00 66.14  ? 210 LYS B CG  1 
ATOM   5718 C CD  . LYS D 4 210 ? 165.087 191.168 185.398 1.00 66.14  ? 210 LYS B CD  1 
ATOM   5719 C CE  . LYS D 4 210 ? 166.017 189.968 185.540 1.00 66.14  ? 210 LYS B CE  1 
ATOM   5720 N NZ  . LYS D 4 210 ? 166.524 189.803 186.929 1.00 66.14  ? 210 LYS B NZ  1 
ATOM   5721 N N   . TRP D 4 211 ? 160.378 188.829 184.008 1.00 65.38  ? 211 TRP B N   1 
ATOM   5722 C CA  . TRP D 4 211 ? 159.607 187.647 183.645 1.00 65.38  ? 211 TRP B CA  1 
ATOM   5723 C C   . TRP D 4 211 ? 159.009 187.749 182.250 1.00 65.38  ? 211 TRP B C   1 
ATOM   5724 O O   . TRP D 4 211 ? 158.206 186.891 181.869 1.00 65.38  ? 211 TRP B O   1 
ATOM   5725 C CB  . TRP D 4 211 ? 158.500 187.356 184.666 1.00 65.38  ? 211 TRP B CB  1 
ATOM   5726 C CG  . TRP D 4 211 ? 157.588 188.496 185.002 1.00 65.38  ? 211 TRP B CG  1 
ATOM   5727 C CD1 . TRP D 4 211 ? 157.699 189.334 186.064 1.00 65.38  ? 211 TRP B CD1 1 
ATOM   5728 C CD2 . TRP D 4 211 ? 156.402 188.895 184.298 1.00 65.38  ? 211 TRP B CD2 1 
ATOM   5729 N NE1 . TRP D 4 211 ? 156.671 190.244 186.062 1.00 65.38  ? 211 TRP B NE1 1 
ATOM   5730 C CE2 . TRP D 4 211 ? 155.860 189.995 184.987 1.00 65.38  ? 211 TRP B CE2 1 
ATOM   5731 C CE3 . TRP D 4 211 ? 155.753 188.435 183.149 1.00 65.38  ? 211 TRP B CE3 1 
ATOM   5732 C CZ2 . TRP D 4 211 ? 154.701 190.642 184.566 1.00 65.38  ? 211 TRP B CZ2 1 
ATOM   5733 C CZ3 . TRP D 4 211 ? 154.602 189.078 182.733 1.00 65.38  ? 211 TRP B CZ3 1 
ATOM   5734 C CH2 . TRP D 4 211 ? 154.088 190.169 183.440 1.00 65.38  ? 211 TRP B CH2 1 
ATOM   5735 N N   . ILE D 4 212 ? 159.392 188.762 181.473 1.00 62.74  ? 212 ILE B N   1 
ATOM   5736 C CA  . ILE D 4 212 ? 158.876 188.882 180.117 1.00 62.74  ? 212 ILE B CA  1 
ATOM   5737 C C   . ILE D 4 212 ? 159.653 187.996 179.147 1.00 62.74  ? 212 ILE B C   1 
ATOM   5738 O O   . ILE D 4 212 ? 159.191 187.761 178.024 1.00 62.74  ? 212 ILE B O   1 
ATOM   5739 C CB  . ILE D 4 212 ? 158.897 190.362 179.694 1.00 62.74  ? 212 ILE B CB  1 
ATOM   5740 C CG1 . ILE D 4 212 ? 157.906 190.622 178.559 1.00 62.74  ? 212 ILE B CG1 1 
ATOM   5741 C CG2 . ILE D 4 212 ? 160.304 190.793 179.296 1.00 62.74  ? 212 ILE B CG2 1 
ATOM   5742 C CD1 . ILE D 4 212 ? 156.466 190.415 178.961 1.00 62.74  ? 212 ILE B CD1 1 
ATOM   5743 N N   . HIS D 4 213 ? 160.806 187.465 179.559 1.00 60.67  ? 213 HIS B N   1 
ATOM   5744 C CA  . HIS D 4 213 ? 161.599 186.604 178.691 1.00 60.67  ? 213 HIS B CA  1 
ATOM   5745 C C   . HIS D 4 213 ? 161.082 185.174 178.643 1.00 60.67  ? 213 HIS B C   1 
ATOM   5746 O O   . HIS D 4 213 ? 161.624 184.365 177.884 1.00 60.67  ? 213 HIS B O   1 
ATOM   5747 C CB  . HIS D 4 213 ? 163.068 186.603 179.124 1.00 60.67  ? 213 HIS B CB  1 
ATOM   5748 C CG  . HIS D 4 213 ? 163.274 186.338 180.583 1.00 60.67  ? 213 HIS B CG  1 
ATOM   5749 N ND1 . HIS D 4 213 ? 162.944 185.140 181.179 1.00 60.67  ? 213 HIS B ND1 1 
ATOM   5750 C CD2 . HIS D 4 213 ? 163.787 187.116 181.565 1.00 60.67  ? 213 HIS B CD2 1 
ATOM   5751 C CE1 . HIS D 4 213 ? 163.238 185.193 182.465 1.00 60.67  ? 213 HIS B CE1 1 
ATOM   5752 N NE2 . HIS D 4 213 ? 163.751 186.382 182.725 1.00 60.67  ? 213 HIS B NE2 1 
ATOM   5753 N N   . CYS D 4 214 ? 160.064 184.842 179.432 1.00 60.12  ? 214 CYS B N   1 
ATOM   5754 C CA  . CYS D 4 214 ? 159.447 183.523 179.382 1.00 60.12  ? 214 CYS B CA  1 
ATOM   5755 C C   . CYS D 4 214 ? 158.384 183.417 178.301 1.00 60.12  ? 214 CYS B C   1 
ATOM   5756 O O   . CYS D 4 214 ? 157.750 182.364 178.177 1.00 60.12  ? 214 CYS B O   1 
ATOM   5757 C CB  . CYS D 4 214 ? 158.836 183.172 180.741 1.00 60.12  ? 214 CYS B CB  1 
ATOM   5758 S SG  . CYS D 4 214 ? 159.845 183.642 182.162 1.00 60.12  ? 214 CYS B SG  1 
ATOM   5759 N N   . PHE D 4 215 ? 158.177 184.477 177.523 1.00 53.85  ? 215 PHE B N   1 
ATOM   5760 C CA  . PHE D 4 215 ? 157.155 184.531 176.484 1.00 53.85  ? 215 PHE B CA  1 
ATOM   5761 C C   . PHE D 4 215 ? 157.789 184.769 175.119 1.00 53.85  ? 215 PHE B C   1 
ATOM   5762 O O   . PHE D 4 215 ? 157.340 185.605 174.335 1.00 53.85  ? 215 PHE B O   1 
ATOM   5763 C CB  . PHE D 4 215 ? 156.120 185.617 176.765 1.00 53.85  ? 215 PHE B CB  1 
ATOM   5764 C CG  . PHE D 4 215 ? 155.445 185.497 178.102 1.00 53.85  ? 215 PHE B CG  1 
ATOM   5765 C CD1 . PHE D 4 215 ? 155.977 186.114 179.223 1.00 53.85  ? 215 PHE B CD1 1 
ATOM   5766 C CD2 . PHE D 4 215 ? 154.260 184.795 178.231 1.00 53.85  ? 215 PHE B CD2 1 
ATOM   5767 C CE1 . PHE D 4 215 ? 155.349 186.014 180.446 1.00 53.85  ? 215 PHE B CE1 1 
ATOM   5768 C CE2 . PHE D 4 215 ? 153.629 184.696 179.450 1.00 53.85  ? 215 PHE B CE2 1 
ATOM   5769 C CZ  . PHE D 4 215 ? 154.174 185.303 180.559 1.00 53.85  ? 215 PHE B CZ  1 
ATOM   5770 N N   . GLU D 4 216 ? 158.872 184.050 174.821 1.00 55.76  ? 216 GLU B N   1 
ATOM   5771 C CA  . GLU D 4 216 ? 159.394 184.060 173.458 1.00 55.76  ? 216 GLU B CA  1 
ATOM   5772 C C   . GLU D 4 216 ? 158.559 183.164 172.556 1.00 55.76  ? 216 GLU B C   1 
ATOM   5773 O O   . GLU D 4 216 ? 158.400 183.440 171.362 1.00 55.76  ? 216 GLU B O   1 
ATOM   5774 C CB  . GLU D 4 216 ? 160.855 183.621 173.443 1.00 55.76  ? 216 GLU B CB  1 
ATOM   5775 C CG  . GLU D 4 216 ? 161.680 184.291 174.503 1.00 55.76  ? 216 GLU B CG  1 
ATOM   5776 C CD  . GLU D 4 216 ? 161.636 185.792 174.396 1.00 55.76  ? 216 GLU B CD  1 
ATOM   5777 O OE1 . GLU D 4 216 ? 161.800 186.323 173.278 1.00 55.76  ? 216 GLU B OE1 1 
ATOM   5778 O OE2 . GLU D 4 216 ? 161.413 186.434 175.438 1.00 55.76  ? 216 GLU B OE2 1 
ATOM   5779 N N   . GLY D 4 217 ? 158.019 182.083 173.114 1.00 50.88  ? 217 GLY B N   1 
ATOM   5780 C CA  . GLY D 4 217 ? 157.214 181.135 172.379 1.00 50.88  ? 217 GLY B CA  1 
ATOM   5781 C C   . GLY D 4 217 ? 155.788 181.557 172.135 1.00 50.88  ? 217 GLY B C   1 
ATOM   5782 O O   . GLY D 4 217 ? 155.034 180.814 171.503 1.00 50.88  ? 217 GLY B O   1 
ATOM   5783 N N   . VAL D 4 218 ? 155.389 182.731 172.627 1.00 42.35  ? 218 VAL B N   1 
ATOM   5784 C CA  . VAL D 4 218 ? 154.058 183.247 172.342 1.00 42.35  ? 218 VAL B CA  1 
ATOM   5785 C C   . VAL D 4 218 ? 153.999 183.670 170.880 1.00 42.35  ? 218 VAL B C   1 
ATOM   5786 O O   . VAL D 4 218 ? 155.022 184.011 170.268 1.00 42.35  ? 218 VAL B O   1 
ATOM   5787 C CB  . VAL D 4 218 ? 153.713 184.403 173.300 1.00 42.35  ? 218 VAL B CB  1 
ATOM   5788 C CG1 . VAL D 4 218 ? 154.421 185.690 172.909 1.00 42.35  ? 218 VAL B CG1 1 
ATOM   5789 C CG2 . VAL D 4 218 ? 152.217 184.604 173.388 1.00 42.35  ? 218 VAL B CG2 1 
ATOM   5790 N N   . THR D 4 219 ? 152.808 183.597 170.292 1.00 38.40  ? 219 THR B N   1 
ATOM   5791 C CA  . THR D 4 219 ? 152.661 183.873 168.872 1.00 38.40  ? 219 THR B CA  1 
ATOM   5792 C C   . THR D 4 219 ? 152.102 185.261 168.585 1.00 38.40  ? 219 THR B C   1 
ATOM   5793 O O   . THR D 4 219 ? 152.237 185.740 167.455 1.00 38.40  ? 219 THR B O   1 
ATOM   5794 C CB  . THR D 4 219 ? 151.767 182.809 168.227 1.00 38.40  ? 219 THR B CB  1 
ATOM   5795 O OG1 . THR D 4 219 ? 151.930 182.843 166.808 1.00 38.40  ? 219 THR B OG1 1 
ATOM   5796 C CG2 . THR D 4 219 ? 150.315 183.067 168.555 1.00 38.40  ? 219 THR B CG2 1 
ATOM   5797 N N   . ALA D 4 220 ? 151.501 185.918 169.578 1.00 31.52  ? 220 ALA B N   1 
ATOM   5798 C CA  . ALA D 4 220 ? 150.857 187.211 169.397 1.00 31.52  ? 220 ALA B CA  1 
ATOM   5799 C C   . ALA D 4 220 ? 150.620 187.834 170.764 1.00 31.52  ? 220 ALA B C   1 
ATOM   5800 O O   . ALA D 4 220 ? 150.596 187.143 171.785 1.00 31.52  ? 220 ALA B O   1 
ATOM   5801 C CB  . ALA D 4 220 ? 149.538 187.084 168.633 1.00 31.52  ? 220 ALA B CB  1 
ATOM   5802 N N   . ILE D 4 221 ? 150.426 189.149 170.763 1.00 25.39  ? 221 ILE B N   1 
ATOM   5803 C CA  . ILE D 4 221 ? 150.230 189.935 171.974 1.00 25.39  ? 221 ILE B CA  1 
ATOM   5804 C C   . ILE D 4 221 ? 148.869 190.608 171.880 1.00 25.39  ? 221 ILE B C   1 
ATOM   5805 O O   . ILE D 4 221 ? 148.637 191.413 170.973 1.00 25.39  ? 221 ILE B O   1 
ATOM   5806 C CB  . ILE D 4 221 ? 151.329 190.998 172.131 1.00 25.39  ? 221 ILE B CB  1 
ATOM   5807 C CG1 . ILE D 4 221 ? 152.702 190.354 172.284 1.00 25.39  ? 221 ILE B CG1 1 
ATOM   5808 C CG2 . ILE D 4 221 ? 151.034 191.877 173.326 1.00 25.39  ? 221 ILE B CG2 1 
ATOM   5809 C CD1 . ILE D 4 221 ? 153.814 191.367 172.419 1.00 25.39  ? 221 ILE B CD1 1 
ATOM   5810 N N   . ILE D 4 222 ? 147.981 190.306 172.817 1.00 21.67  ? 222 ILE B N   1 
ATOM   5811 C CA  . ILE D 4 222 ? 146.678 190.955 172.874 1.00 21.67  ? 222 ILE B CA  1 
ATOM   5812 C C   . ILE D 4 222 ? 146.771 192.114 173.849 1.00 21.67  ? 222 ILE B C   1 
ATOM   5813 O O   . ILE D 4 222 ? 147.145 191.931 175.013 1.00 21.67  ? 222 ILE B O   1 
ATOM   5814 C CB  . ILE D 4 222 ? 145.569 189.975 173.275 1.00 21.67  ? 222 ILE B CB  1 
ATOM   5815 C CG1 . ILE D 4 222 ? 145.454 188.861 172.239 1.00 21.67  ? 222 ILE B CG1 1 
ATOM   5816 C CG2 . ILE D 4 222 ? 144.251 190.695 173.408 1.00 21.67  ? 222 ILE B CG2 1 
ATOM   5817 C CD1 . ILE D 4 222 ? 144.525 187.761 172.657 1.00 21.67  ? 222 ILE B CD1 1 
ATOM   5818 N N   . PHE D 4 223 ? 146.435 193.307 173.372 1.00 37.42  ? 223 PHE B N   1 
ATOM   5819 C CA  . PHE D 4 223 ? 146.576 194.556 174.113 1.00 37.42  ? 223 PHE B CA  1 
ATOM   5820 C C   . PHE D 4 223 ? 145.200 195.210 174.214 1.00 37.42  ? 223 PHE B C   1 
ATOM   5821 O O   . PHE D 4 223 ? 144.830 196.025 173.367 1.00 37.42  ? 223 PHE B O   1 
ATOM   5822 C CB  . PHE D 4 223 ? 147.572 195.460 173.407 1.00 37.42  ? 223 PHE B CB  1 
ATOM   5823 C CG  . PHE D 4 223 ? 148.251 196.438 174.306 1.00 37.42  ? 223 PHE B CG  1 
ATOM   5824 C CD1 . PHE D 4 223 ? 149.455 196.127 174.900 1.00 37.42  ? 223 PHE B CD1 1 
ATOM   5825 C CD2 . PHE D 4 223 ? 147.680 197.669 174.565 1.00 37.42  ? 223 PHE B CD2 1 
ATOM   5826 C CE1 . PHE D 4 223 ? 150.084 197.031 175.729 1.00 37.42  ? 223 PHE B CE1 1 
ATOM   5827 C CE2 . PHE D 4 223 ? 148.307 198.576 175.394 1.00 37.42  ? 223 PHE B CE2 1 
ATOM   5828 C CZ  . PHE D 4 223 ? 149.506 198.252 175.981 1.00 37.42  ? 223 PHE B CZ  1 
ATOM   5829 N N   . CYS D 4 224 ? 144.439 194.858 175.246 1.00 46.73  ? 224 CYS B N   1 
ATOM   5830 C CA  . CYS D 4 224 ? 143.095 195.396 175.429 1.00 46.73  ? 224 CYS B CA  1 
ATOM   5831 C C   . CYS D 4 224 ? 143.179 196.705 176.202 1.00 46.73  ? 224 CYS B C   1 
ATOM   5832 O O   . CYS D 4 224 ? 143.556 196.716 177.378 1.00 46.73  ? 224 CYS B O   1 
ATOM   5833 C CB  . CYS D 4 224 ? 142.203 194.394 176.155 1.00 46.73  ? 224 CYS B CB  1 
ATOM   5834 S SG  . CYS D 4 224 ? 141.962 192.836 175.286 1.00 46.73  ? 224 CYS B SG  1 
ATOM   5835 N N   . VAL D 4 225 ? 142.829 197.810 175.544 1.00 54.17  ? 225 VAL B N   1 
ATOM   5836 C CA  . VAL D 4 225 ? 142.709 199.106 176.200 1.00 54.17  ? 225 VAL B CA  1 
ATOM   5837 C C   . VAL D 4 225 ? 141.402 199.764 175.782 1.00 54.17  ? 225 VAL B C   1 
ATOM   5838 O O   . VAL D 4 225 ? 140.880 199.524 174.690 1.00 54.17  ? 225 VAL B O   1 
ATOM   5839 C CB  . VAL D 4 225 ? 143.904 200.032 175.896 1.00 54.17  ? 225 VAL B CB  1 
ATOM   5840 C CG1 . VAL D 4 225 ? 145.126 199.562 176.656 1.00 54.17  ? 225 VAL B CG1 1 
ATOM   5841 C CG2 . VAL D 4 225 ? 144.181 200.072 174.409 1.00 54.17  ? 225 VAL B CG2 1 
ATOM   5842 N N   . ALA D 4 226 ? 140.891 200.623 176.657 1.00 65.50  ? 226 ALA B N   1 
ATOM   5843 C CA  . ALA D 4 226 ? 139.571 201.217 176.509 1.00 65.50  ? 226 ALA B CA  1 
ATOM   5844 C C   . ALA D 4 226 ? 139.689 202.594 175.877 1.00 65.50  ? 226 ALA B C   1 
ATOM   5845 O O   . ALA D 4 226 ? 140.621 203.344 176.184 1.00 65.50  ? 226 ALA B O   1 
ATOM   5846 C CB  . ALA D 4 226 ? 138.874 201.324 177.864 1.00 65.50  ? 226 ALA B CB  1 
ATOM   5847 N N   . LEU D 4 227 ? 138.746 202.922 174.992 1.00 70.55  ? 227 LEU B N   1 
ATOM   5848 C CA  . LEU D 4 227 ? 138.758 204.244 174.376 1.00 70.55  ? 227 LEU B CA  1 
ATOM   5849 C C   . LEU D 4 227 ? 138.110 205.291 175.270 1.00 70.55  ? 227 LEU B C   1 
ATOM   5850 O O   . LEU D 4 227 ? 138.397 206.485 175.128 1.00 70.55  ? 227 LEU B O   1 
ATOM   5851 C CB  . LEU D 4 227 ? 138.063 204.203 173.018 1.00 70.55  ? 227 LEU B CB  1 
ATOM   5852 C CG  . LEU D 4 227 ? 138.685 203.230 172.022 1.00 70.55  ? 227 LEU B CG  1 
ATOM   5853 C CD1 . LEU D 4 227 ? 137.679 202.835 170.962 1.00 70.55  ? 227 LEU B CD1 1 
ATOM   5854 C CD2 . LEU D 4 227 ? 139.914 203.851 171.399 1.00 70.55  ? 227 LEU B CD2 1 
ATOM   5855 N N   . SER D 4 228 ? 137.257 204.873 176.200 1.00 81.68  ? 228 SER B N   1 
ATOM   5856 C CA  . SER D 4 228 ? 136.543 205.804 177.063 1.00 81.68  ? 228 SER B CA  1 
ATOM   5857 C C   . SER D 4 228 ? 137.389 206.304 178.226 1.00 81.68  ? 228 SER B C   1 
ATOM   5858 O O   . SER D 4 228 ? 136.893 207.091 179.038 1.00 81.68  ? 228 SER B O   1 
ATOM   5859 C CB  . SER D 4 228 ? 135.268 205.150 177.599 1.00 81.68  ? 228 SER B CB  1 
ATOM   5860 O OG  . SER D 4 228 ? 134.414 204.756 176.541 1.00 81.68  ? 228 SER B OG  1 
ATOM   5861 N N   . ASP D 4 229 ? 138.643 205.875 178.323 1.00 87.08  ? 229 ASP B N   1 
ATOM   5862 C CA  . ASP D 4 229 ? 139.525 206.237 179.425 1.00 87.08  ? 229 ASP B CA  1 
ATOM   5863 C C   . ASP D 4 229 ? 140.514 207.321 179.010 1.00 87.08  ? 229 ASP B C   1 
ATOM   5864 O O   . ASP D 4 229 ? 141.671 207.323 179.432 1.00 87.08  ? 229 ASP B O   1 
ATOM   5865 C CB  . ASP D 4 229 ? 140.263 205.008 179.945 1.00 87.08  ? 229 ASP B CB  1 
ATOM   5866 C CG  . ASP D 4 229 ? 139.418 204.180 180.894 1.00 87.08  ? 229 ASP B CG  1 
ATOM   5867 O OD1 . ASP D 4 229 ? 138.175 204.287 180.831 1.00 87.08  ? 229 ASP B OD1 1 
ATOM   5868 O OD2 . ASP D 4 229 ? 139.993 203.415 181.695 1.00 87.08  ? 229 ASP B OD2 1 
ATOM   5869 N N   . TYR D 4 230 ? 140.068 208.254 178.171 1.00 90.88  ? 230 TYR B N   1 
ATOM   5870 C CA  . TYR D 4 230 ? 140.927 209.336 177.710 1.00 90.88  ? 230 TYR B CA  1 
ATOM   5871 C C   . TYR D 4 230 ? 140.851 210.582 178.581 1.00 90.88  ? 230 TYR B C   1 
ATOM   5872 O O   . TYR D 4 230 ? 141.846 211.305 178.688 1.00 90.88  ? 230 TYR B O   1 
ATOM   5873 C CB  . TYR D 4 230 ? 140.586 209.709 176.261 1.00 90.88  ? 230 TYR B CB  1 
ATOM   5874 C CG  . TYR D 4 230 ? 139.336 210.548 176.090 1.00 90.88  ? 230 TYR B CG  1 
ATOM   5875 C CD1 . TYR D 4 230 ? 138.074 209.994 176.256 1.00 90.88  ? 230 TYR B CD1 1 
ATOM   5876 C CD2 . TYR D 4 230 ? 139.419 211.889 175.742 1.00 90.88  ? 230 TYR B CD2 1 
ATOM   5877 C CE1 . TYR D 4 230 ? 136.931 210.756 176.095 1.00 90.88  ? 230 TYR B CE1 1 
ATOM   5878 C CE2 . TYR D 4 230 ? 138.282 212.658 175.577 1.00 90.88  ? 230 TYR B CE2 1 
ATOM   5879 C CZ  . TYR D 4 230 ? 137.041 212.086 175.754 1.00 90.88  ? 230 TYR B CZ  1 
ATOM   5880 O OH  . TYR D 4 230 ? 135.907 212.845 175.590 1.00 90.88  ? 230 TYR B OH  1 
ATOM   5881 N N   . ASP D 4 231 ? 139.709 210.850 179.215 1.00 94.22  ? 231 ASP B N   1 
ATOM   5882 C CA  . ASP D 4 231 ? 139.565 212.077 179.989 1.00 94.22  ? 231 ASP B CA  1 
ATOM   5883 C C   . ASP D 4 231 ? 139.850 211.880 181.474 1.00 94.22  ? 231 ASP B C   1 
ATOM   5884 O O   . ASP D 4 231 ? 140.586 212.676 182.067 1.00 94.22  ? 231 ASP B O   1 
ATOM   5885 C CB  . ASP D 4 231 ? 138.164 212.663 179.793 1.00 94.22  ? 231 ASP B CB  1 
ATOM   5886 C CG  . ASP D 4 231 ? 137.067 211.648 180.026 1.00 94.22  ? 231 ASP B CG  1 
ATOM   5887 O OD1 . ASP D 4 231 ? 137.385 210.457 180.223 1.00 94.22  ? 231 ASP B OD1 1 
ATOM   5888 O OD2 . ASP D 4 231 ? 135.884 212.044 180.015 1.00 94.22  ? 231 ASP B OD2 1 
ATOM   5889 N N   . LEU D 4 232 ? 139.291 210.843 182.093 1.00 96.52  ? 232 LEU B N   1 
ATOM   5890 C CA  . LEU D 4 232 ? 139.495 210.620 183.517 1.00 96.52  ? 232 LEU B CA  1 
ATOM   5891 C C   . LEU D 4 232 ? 140.894 210.069 183.766 1.00 96.52  ? 232 LEU B C   1 
ATOM   5892 O O   . LEU D 4 232 ? 141.393 209.230 183.011 1.00 96.52  ? 232 LEU B O   1 
ATOM   5893 C CB  . LEU D 4 232 ? 138.429 209.674 184.084 1.00 96.52  ? 232 LEU B CB  1 
ATOM   5894 C CG  . LEU D 4 232 ? 138.414 208.163 183.816 1.00 96.52  ? 232 LEU B CG  1 
ATOM   5895 C CD1 . LEU D 4 232 ? 137.513 207.467 184.823 1.00 96.52  ? 232 LEU B CD1 1 
ATOM   5896 C CD2 . LEU D 4 232 ? 137.959 207.836 182.405 1.00 96.52  ? 232 LEU B CD2 1 
ATOM   5897 N N   . VAL D 4 233 ? 141.535 210.562 184.822 1.00 104.80 ? 233 VAL B N   1 
ATOM   5898 C CA  . VAL D 4 233 ? 142.938 210.241 185.071 1.00 104.80 ? 233 VAL B CA  1 
ATOM   5899 C C   . VAL D 4 233 ? 143.092 209.031 185.995 1.00 104.80 ? 233 VAL B C   1 
ATOM   5900 O O   . VAL D 4 233 ? 143.791 208.073 185.655 1.00 104.80 ? 233 VAL B O   1 
ATOM   5901 C CB  . VAL D 4 233 ? 143.688 211.499 185.582 1.00 104.80 ? 233 VAL B CB  1 
ATOM   5902 C CG1 . VAL D 4 233 ? 143.732 212.544 184.486 1.00 104.80 ? 233 VAL B CG1 1 
ATOM   5903 C CG2 . VAL D 4 233 ? 142.999 212.137 186.785 1.00 104.80 ? 233 VAL B CG2 1 
ATOM   5904 N N   . LEU D 4 234 ? 142.472 209.037 187.177 1.00 113.36 ? 234 LEU B N   1 
ATOM   5905 C CA  . LEU D 4 234 ? 142.449 207.862 188.040 1.00 113.36 ? 234 LEU B CA  1 
ATOM   5906 C C   . LEU D 4 234 ? 141.110 207.613 188.714 1.00 113.36 ? 234 LEU B C   1 
ATOM   5907 O O   . LEU D 4 234 ? 140.946 206.542 189.308 1.00 113.36 ? 234 LEU B O   1 
ATOM   5908 C CB  . LEU D 4 234 ? 143.532 207.963 189.124 1.00 113.36 ? 234 LEU B CB  1 
ATOM   5909 C CG  . LEU D 4 234 ? 144.926 207.451 188.760 1.00 113.36 ? 234 LEU B CG  1 
ATOM   5910 C CD1 . LEU D 4 234 ? 145.858 207.583 189.950 1.00 113.36 ? 234 LEU B CD1 1 
ATOM   5911 C CD2 . LEU D 4 234 ? 144.869 206.010 188.275 1.00 113.36 ? 234 LEU B CD2 1 
ATOM   5912 N N   . ALA D 4 235 ? 140.182 208.582 188.696 1.00 120.86 ? 235 ALA B N   1 
ATOM   5913 C CA  . ALA D 4 235 ? 138.899 208.605 189.407 1.00 120.86 ? 235 ALA B CA  1 
ATOM   5914 C C   . ALA D 4 235 ? 139.062 208.594 190.928 1.00 120.86 ? 235 ALA B C   1 
ATOM   5915 O O   . ALA D 4 235 ? 138.069 208.517 191.659 1.00 120.86 ? 235 ALA B O   1 
ATOM   5916 C CB  . ALA D 4 235 ? 137.986 207.454 188.962 1.00 120.86 ? 235 ALA B CB  1 
ATOM   5917 N N   . GLU D 4 236 ? 140.302 208.671 191.414 1.00 125.54 ? 236 GLU B N   1 
ATOM   5918 C CA  . GLU D 4 236 ? 140.594 208.832 192.832 1.00 125.54 ? 236 GLU B CA  1 
ATOM   5919 C C   . GLU D 4 236 ? 141.693 209.844 193.117 1.00 125.54 ? 236 GLU B C   1 
ATOM   5920 O O   . GLU D 4 236 ? 141.746 210.366 194.238 1.00 125.54 ? 236 GLU B O   1 
ATOM   5921 C CB  . GLU D 4 236 ? 140.988 207.486 193.460 1.00 125.54 ? 236 GLU B CB  1 
ATOM   5922 N N   . ASP D 4 237 ? 142.563 210.140 192.153 1.00 125.72 ? 237 ASP B N   1 
ATOM   5923 C CA  . ASP D 4 237 ? 143.646 211.093 192.335 1.00 125.72 ? 237 ASP B CA  1 
ATOM   5924 C C   . ASP D 4 237 ? 143.993 211.691 190.979 1.00 125.72 ? 237 ASP B C   1 
ATOM   5925 O O   . ASP D 4 237 ? 143.608 211.168 189.930 1.00 125.72 ? 237 ASP B O   1 
ATOM   5926 C CB  . ASP D 4 237 ? 144.872 210.435 192.978 1.00 125.72 ? 237 ASP B CB  1 
ATOM   5927 C CG  . ASP D 4 237 ? 145.588 211.358 193.944 1.00 125.72 ? 237 ASP B CG  1 
ATOM   5928 O OD1 . ASP D 4 237 ? 145.183 212.534 194.056 1.00 125.72 ? 237 ASP B OD1 1 
ATOM   5929 O OD2 . ASP D 4 237 ? 146.557 210.908 194.591 1.00 125.72 ? 237 ASP B OD2 1 
ATOM   5930 N N   . GLU D 4 238 ? 144.730 212.801 191.008 1.00 123.98 ? 238 GLU B N   1 
ATOM   5931 C CA  . GLU D 4 238 ? 145.047 213.574 189.806 1.00 123.98 ? 238 GLU B CA  1 
ATOM   5932 C C   . GLU D 4 238 ? 146.563 213.706 189.679 1.00 123.98 ? 238 GLU B C   1 
ATOM   5933 O O   . GLU D 4 238 ? 147.153 214.672 190.172 1.00 123.98 ? 238 GLU B O   1 
ATOM   5934 C CB  . GLU D 4 238 ? 144.367 214.944 189.855 1.00 123.98 ? 238 GLU B CB  1 
ATOM   5935 C CG  . GLU D 4 238 ? 144.514 215.770 188.585 1.00 123.98 ? 238 GLU B CG  1 
ATOM   5936 C CD  . GLU D 4 238 ? 143.358 215.574 187.625 1.00 123.98 ? 238 GLU B CD  1 
ATOM   5937 O OE1 . GLU D 4 238 ? 142.222 215.360 188.097 1.00 123.98 ? 238 GLU B OE1 1 
ATOM   5938 O OE2 . GLU D 4 238 ? 143.586 215.633 186.398 1.00 123.98 ? 238 GLU B OE2 1 
ATOM   5939 N N   . GLU D 4 239 ? 147.199 212.729 189.030 1.00 117.24 ? 239 GLU B N   1 
ATOM   5940 C CA  . GLU D 4 239 ? 148.604 212.877 188.658 1.00 117.24 ? 239 GLU B CA  1 
ATOM   5941 C C   . GLU D 4 239 ? 148.934 212.430 187.242 1.00 117.24 ? 239 GLU B C   1 
ATOM   5942 O O   . GLU D 4 239 ? 149.921 212.923 186.686 1.00 117.24 ? 239 GLU B O   1 
ATOM   5943 C CB  . GLU D 4 239 ? 149.511 212.118 189.638 1.00 117.24 ? 239 GLU B CB  1 
ATOM   5944 C CG  . GLU D 4 239 ? 149.383 210.606 189.589 1.00 117.24 ? 239 GLU B CG  1 
ATOM   5945 C CD  . GLU D 4 239 ? 148.530 210.061 190.711 1.00 117.24 ? 239 GLU B CD  1 
ATOM   5946 O OE1 . GLU D 4 239 ? 147.707 210.825 191.256 1.00 117.24 ? 239 GLU B OE1 1 
ATOM   5947 O OE2 . GLU D 4 239 ? 148.691 208.872 191.055 1.00 117.24 ? 239 GLU B OE2 1 
ATOM   5948 N N   . MET D 4 240 ? 148.152 211.543 186.625 1.00 108.14 ? 240 MET B N   1 
ATOM   5949 C CA  . MET D 4 240 ? 148.472 211.026 185.302 1.00 108.14 ? 240 MET B CA  1 
ATOM   5950 C C   . MET D 4 240 ? 147.224 210.406 184.694 1.00 108.14 ? 240 MET B C   1 
ATOM   5951 O O   . MET D 4 240 ? 146.458 209.734 185.389 1.00 108.14 ? 240 MET B O   1 
ATOM   5952 C CB  . MET D 4 240 ? 149.598 209.985 185.361 1.00 108.14 ? 240 MET B CB  1 
ATOM   5953 N N   . ASN D 4 241 ? 147.033 210.633 183.397 1.00 96.54  ? 241 ASN B N   1 
ATOM   5954 C CA  . ASN D 4 241 ? 145.913 210.038 182.683 1.00 96.54  ? 241 ASN B CA  1 
ATOM   5955 C C   . ASN D 4 241 ? 146.144 208.548 182.460 1.00 96.54  ? 241 ASN B C   1 
ATOM   5956 O O   . ASN D 4 241 ? 147.281 208.073 182.400 1.00 96.54  ? 241 ASN B O   1 
ATOM   5957 C CB  . ASN D 4 241 ? 145.703 210.738 181.341 1.00 96.54  ? 241 ASN B CB  1 
ATOM   5958 C CG  . ASN D 4 241 ? 144.271 210.643 180.852 1.00 96.54  ? 241 ASN B CG  1 
ATOM   5959 O OD1 . ASN D 4 241 ? 143.327 210.832 181.619 1.00 96.54  ? 241 ASN B OD1 1 
ATOM   5960 N ND2 . ASN D 4 241 ? 144.102 210.347 179.569 1.00 96.54  ? 241 ASN B ND2 1 
ATOM   5961 N N   . ARG D 4 242 ? 145.040 207.805 182.340 1.00 95.41  ? 242 ARG B N   1 
ATOM   5962 C CA  . ARG D 4 242 ? 145.141 206.379 182.048 1.00 95.41  ? 242 ARG B CA  1 
ATOM   5963 C C   . ARG D 4 242 ? 145.634 206.131 180.628 1.00 95.41  ? 242 ARG B C   1 
ATOM   5964 O O   . ARG D 4 242 ? 146.349 205.150 180.383 1.00 95.41  ? 242 ARG B O   1 
ATOM   5965 C CB  . ARG D 4 242 ? 143.789 205.701 182.261 1.00 95.41  ? 242 ARG B CB  1 
ATOM   5966 C CG  . ARG D 4 242 ? 143.443 205.440 183.714 1.00 95.41  ? 242 ARG B CG  1 
ATOM   5967 C CD  . ARG D 4 242 ? 142.124 204.697 183.832 1.00 95.41  ? 242 ARG B CD  1 
ATOM   5968 N NE  . ARG D 4 242 ? 141.818 204.324 185.208 1.00 95.41  ? 242 ARG B NE  1 
ATOM   5969 C CZ  . ARG D 4 242 ? 141.101 205.065 186.041 1.00 95.41  ? 242 ARG B CZ  1 
ATOM   5970 N NH1 . ARG D 4 242 ? 140.600 206.232 185.671 1.00 95.41  ? 242 ARG B NH1 1 
ATOM   5971 N NH2 . ARG D 4 242 ? 140.880 204.624 187.276 1.00 95.41  ? 242 ARG B NH2 1 
ATOM   5972 N N   . MET D 4 243 ? 145.266 207.004 179.687 1.00 84.83  ? 243 MET B N   1 
ATOM   5973 C CA  . MET D 4 243 ? 145.656 206.807 178.296 1.00 84.83  ? 243 MET B CA  1 
ATOM   5974 C C   . MET D 4 243 ? 147.154 206.998 178.104 1.00 84.83  ? 243 MET B C   1 
ATOM   5975 O O   . MET D 4 243 ? 147.773 206.301 177.293 1.00 84.83  ? 243 MET B O   1 
ATOM   5976 C CB  . MET D 4 243 ? 144.876 207.759 177.393 1.00 84.83  ? 243 MET B CB  1 
ATOM   5977 C CG  . MET D 4 243 ? 144.757 207.289 175.955 1.00 84.83  ? 243 MET B CG  1 
ATOM   5978 S SD  . MET D 4 243 ? 143.877 205.726 175.793 1.00 84.83  ? 243 MET B SD  1 
ATOM   5979 C CE  . MET D 4 243 ? 142.180 206.295 175.833 1.00 84.83  ? 243 MET B CE  1 
ATOM   5980 N N   . HIS D 4 244 ? 147.755 207.931 178.843 1.00 84.03  ? 244 HIS B N   1 
ATOM   5981 C CA  . HIS D 4 244 ? 149.197 208.138 178.743 1.00 84.03  ? 244 HIS B CA  1 
ATOM   5982 C C   . HIS D 4 244 ? 149.968 206.944 179.294 1.00 84.03  ? 244 HIS B C   1 
ATOM   5983 O O   . HIS D 4 244 ? 150.979 206.527 178.713 1.00 84.03  ? 244 HIS B O   1 
ATOM   5984 C CB  . HIS D 4 244 ? 149.589 209.420 179.473 1.00 84.03  ? 244 HIS B CB  1 
ATOM   5985 C CG  . HIS D 4 244 ? 149.289 210.665 178.699 1.00 84.03  ? 244 HIS B CG  1 
ATOM   5986 N ND1 . HIS D 4 244 ? 148.943 211.854 179.305 1.00 84.03  ? 244 HIS B ND1 1 
ATOM   5987 C CD2 . HIS D 4 244 ? 149.271 210.903 177.366 1.00 84.03  ? 244 HIS B CD2 1 
ATOM   5988 C CE1 . HIS D 4 244 ? 148.731 212.772 178.379 1.00 84.03  ? 244 HIS B CE1 1 
ATOM   5989 N NE2 . HIS D 4 244 ? 148.923 212.221 177.194 1.00 84.03  ? 244 HIS B NE2 1 
ATOM   5990 N N   . GLU D 4 245 ? 149.503 206.378 180.411 1.00 77.19  ? 245 GLU B N   1 
ATOM   5991 C CA  . GLU D 4 245 ? 150.128 205.176 180.952 1.00 77.19  ? 245 GLU B CA  1 
ATOM   5992 C C   . GLU D 4 245 ? 149.949 203.992 180.011 1.00 77.19  ? 245 GLU B C   1 
ATOM   5993 O O   . GLU D 4 245 ? 150.855 203.163 179.873 1.00 77.19  ? 245 GLU B O   1 
ATOM   5994 C CB  . GLU D 4 245 ? 149.555 204.859 182.332 1.00 77.19  ? 245 GLU B CB  1 
ATOM   5995 N N   . SER D 4 246 ? 148.789 203.902 179.352 1.00 73.28  ? 246 SER B N   1 
ATOM   5996 C CA  . SER D 4 246 ? 148.576 202.852 178.358 1.00 73.28  ? 246 SER B CA  1 
ATOM   5997 C C   . SER D 4 246 ? 149.509 203.012 177.164 1.00 73.28  ? 246 SER B C   1 
ATOM   5998 O O   . SER D 4 246 ? 150.029 202.022 176.637 1.00 73.28  ? 246 SER B O   1 
ATOM   5999 C CB  . SER D 4 246 ? 147.124 202.855 177.894 1.00 73.28  ? 246 SER B CB  1 
ATOM   6000 O OG  . SER D 4 246 ? 147.012 202.189 176.652 1.00 73.28  ? 246 SER B OG  1 
ATOM   6001 N N   . MET D 4 247 ? 149.722 204.251 176.719 1.00 72.86  ? 247 MET B N   1 
ATOM   6002 C CA  . MET D 4 247 ? 150.653 204.509 175.625 1.00 72.86  ? 247 MET B CA  1 
ATOM   6003 C C   . MET D 4 247 ? 152.082 204.150 176.018 1.00 72.86  ? 247 MET B C   1 
ATOM   6004 O O   . MET D 4 247 ? 152.829 203.572 175.218 1.00 72.86  ? 247 MET B O   1 
ATOM   6005 C CB  . MET D 4 247 ? 150.556 205.977 175.207 1.00 72.86  ? 247 MET B CB  1 
ATOM   6006 C CG  . MET D 4 247 ? 151.416 206.370 174.019 1.00 72.86  ? 247 MET B CG  1 
ATOM   6007 S SD  . MET D 4 247 ? 151.136 208.091 173.558 1.00 72.86  ? 247 MET B SD  1 
ATOM   6008 C CE  . MET D 4 247 ? 152.327 208.303 172.239 1.00 72.86  ? 247 MET B CE  1 
ATOM   6009 N N   . LYS D 4 248 ? 152.473 204.477 177.253 1.00 66.57  ? 248 LYS B N   1 
ATOM   6010 C CA  . LYS D 4 248 ? 153.803 204.109 177.735 1.00 66.57  ? 248 LYS B CA  1 
ATOM   6011 C C   . LYS D 4 248 ? 153.962 202.596 177.825 1.00 66.57  ? 248 LYS B C   1 
ATOM   6012 O O   . LYS D 4 248 ? 155.015 202.053 177.468 1.00 66.57  ? 248 LYS B O   1 
ATOM   6013 C CB  . LYS D 4 248 ? 154.065 204.756 179.094 1.00 66.57  ? 248 LYS B CB  1 
ATOM   6014 C CG  . LYS D 4 248 ? 154.306 206.256 179.041 1.00 66.57  ? 248 LYS B CG  1 
ATOM   6015 C CD  . LYS D 4 248 ? 154.720 206.787 180.404 1.00 66.57  ? 248 LYS B CD  1 
ATOM   6016 C CE  . LYS D 4 248 ? 153.540 206.830 181.363 1.00 66.57  ? 248 LYS B CE  1 
ATOM   6017 N NZ  . LYS D 4 248 ? 153.905 207.449 182.667 1.00 66.57  ? 248 LYS B NZ  1 
ATOM   6018 N N   . LEU D 4 249 ? 152.924 201.898 178.297 1.00 57.29  ? 249 LEU B N   1 
ATOM   6019 C CA  . LEU D 4 249 ? 152.971 200.441 178.371 1.00 57.29  ? 249 LEU B CA  1 
ATOM   6020 C C   . LEU D 4 249 ? 153.059 199.816 176.983 1.00 57.29  ? 249 LEU B C   1 
ATOM   6021 O O   . LEU D 4 249 ? 153.783 198.833 176.784 1.00 57.29  ? 249 LEU B O   1 
ATOM   6022 C CB  . LEU D 4 249 ? 151.750 199.914 179.124 1.00 57.29  ? 249 LEU B CB  1 
ATOM   6023 C CG  . LEU D 4 249 ? 151.531 198.401 179.103 1.00 57.29  ? 249 LEU B CG  1 
ATOM   6024 C CD1 . LEU D 4 249 ? 152.605 197.709 179.915 1.00 57.29  ? 249 LEU B CD1 1 
ATOM   6025 C CD2 . LEU D 4 249 ? 150.146 198.044 179.616 1.00 57.29  ? 249 LEU B CD2 1 
ATOM   6026 N N   . PHE D 4 250 ? 152.335 200.377 176.010 1.00 50.15  ? 250 PHE B N   1 
ATOM   6027 C CA  . PHE D 4 250 ? 152.410 199.859 174.648 1.00 50.15  ? 250 PHE B CA  1 
ATOM   6028 C C   . PHE D 4 250 ? 153.783 200.098 174.040 1.00 50.15  ? 250 PHE B C   1 
ATOM   6029 O O   . PHE D 4 250 ? 154.302 199.238 173.323 1.00 50.15  ? 250 PHE B O   1 
ATOM   6030 C CB  . PHE D 4 250 ? 151.330 200.488 173.772 1.00 50.15  ? 250 PHE B CB  1 
ATOM   6031 C CG  . PHE D 4 250 ? 151.138 199.781 172.461 1.00 50.15  ? 250 PHE B CG  1 
ATOM   6032 C CD1 . PHE D 4 250 ? 150.296 198.688 172.371 1.00 50.15  ? 250 PHE B CD1 1 
ATOM   6033 C CD2 . PHE D 4 250 ? 151.812 200.197 171.323 1.00 50.15  ? 250 PHE B CD2 1 
ATOM   6034 C CE1 . PHE D 4 250 ? 150.122 198.028 171.172 1.00 50.15  ? 250 PHE B CE1 1 
ATOM   6035 C CE2 . PHE D 4 250 ? 151.643 199.539 170.123 1.00 50.15  ? 250 PHE B CE2 1 
ATOM   6036 C CZ  . PHE D 4 250 ? 150.795 198.454 170.049 1.00 50.15  ? 250 PHE B CZ  1 
ATOM   6037 N N   . ASP D 4 251 ? 154.382 201.261 174.303 1.00 57.03  ? 251 ASP B N   1 
ATOM   6038 C CA  . ASP D 4 251 ? 155.727 201.514 173.797 1.00 57.03  ? 251 ASP B CA  1 
ATOM   6039 C C   . ASP D 4 251 ? 156.758 200.617 174.472 1.00 57.03  ? 251 ASP B C   1 
ATOM   6040 O O   . ASP D 4 251 ? 157.755 200.240 173.845 1.00 57.03  ? 251 ASP B O   1 
ATOM   6041 C CB  . ASP D 4 251 ? 156.097 202.984 173.983 1.00 57.03  ? 251 ASP B CB  1 
ATOM   6042 C CG  . ASP D 4 251 ? 157.485 203.304 173.461 1.00 57.03  ? 251 ASP B CG  1 
ATOM   6043 O OD1 . ASP D 4 251 ? 157.627 203.523 172.239 1.00 57.03  ? 251 ASP B OD1 1 
ATOM   6044 O OD2 . ASP D 4 251 ? 158.433 203.335 174.271 1.00 57.03  ? 251 ASP B OD2 1 
ATOM   6045 N N   . SER D 4 252 ? 156.543 200.272 175.743 1.00 57.03  ? 252 SER B N   1 
ATOM   6046 C CA  . SER D 4 252 ? 157.450 199.349 176.417 1.00 57.03  ? 252 SER B CA  1 
ATOM   6047 C C   . SER D 4 252 ? 157.320 197.935 175.863 1.00 57.03  ? 252 SER B C   1 
ATOM   6048 O O   . SER D 4 252 ? 158.328 197.271 175.601 1.00 57.03  ? 252 SER B O   1 
ATOM   6049 C CB  . SER D 4 252 ? 157.185 199.359 177.921 1.00 57.03  ? 252 SER B CB  1 
ATOM   6050 O OG  . SER D 4 252 ? 155.904 198.829 178.215 1.00 57.03  ? 252 SER B OG  1 
ATOM   6051 N N   . ILE D 4 253 ? 156.087 197.460 175.669 1.00 48.95  ? 253 ILE B N   1 
ATOM   6052 C CA  . ILE D 4 253 ? 155.877 196.071 175.273 1.00 48.95  ? 253 ILE B CA  1 
ATOM   6053 C C   . ILE D 4 253 ? 156.013 195.877 173.765 1.00 48.95  ? 253 ILE B C   1 
ATOM   6054 O O   . ILE D 4 253 ? 156.114 194.737 173.299 1.00 48.95  ? 253 ILE B O   1 
ATOM   6055 C CB  . ILE D 4 253 ? 154.502 195.594 175.773 1.00 48.95  ? 253 ILE B CB  1 
ATOM   6056 C CG1 . ILE D 4 253 ? 154.489 194.080 175.979 1.00 48.95  ? 253 ILE B CG1 1 
ATOM   6057 C CG2 . ILE D 4 253 ? 153.403 195.996 174.805 1.00 48.95  ? 253 ILE B CG2 1 
ATOM   6058 C CD1 . ILE D 4 253 ? 155.371 193.625 177.116 1.00 48.95  ? 253 ILE B CD1 1 
ATOM   6059 N N   . CYS D 4 254 ? 156.029 196.960 172.989 1.00 50.21  ? 254 CYS B N   1 
ATOM   6060 C CA  . CYS D 4 254 ? 156.165 196.876 171.541 1.00 50.21  ? 254 CYS B CA  1 
ATOM   6061 C C   . CYS D 4 254 ? 157.612 196.962 171.082 1.00 50.21  ? 254 CYS B C   1 
ATOM   6062 O O   . CYS D 4 254 ? 157.958 196.403 170.036 1.00 50.21  ? 254 CYS B O   1 
ATOM   6063 C CB  . CYS D 4 254 ? 155.352 197.991 170.877 1.00 50.21  ? 254 CYS B CB  1 
ATOM   6064 S SG  . CYS D 4 254 ? 155.318 197.956 169.074 1.00 50.21  ? 254 CYS B SG  1 
ATOM   6065 N N   . ASN D 4 255 ? 158.465 197.645 171.844 1.00 57.10  ? 255 ASN B N   1 
ATOM   6066 C CA  . ASN D 4 255 ? 159.870 197.812 171.503 1.00 57.10  ? 255 ASN B CA  1 
ATOM   6067 C C   . ASN D 4 255 ? 160.783 196.903 172.318 1.00 57.10  ? 255 ASN B C   1 
ATOM   6068 O O   . ASN D 4 255 ? 161.991 197.155 172.388 1.00 57.10  ? 255 ASN B O   1 
ATOM   6069 C CB  . ASN D 4 255 ? 160.285 199.273 171.677 1.00 57.10  ? 255 ASN B CB  1 
ATOM   6070 C CG  . ASN D 4 255 ? 159.419 200.223 170.877 1.00 57.10  ? 255 ASN B CG  1 
ATOM   6071 O OD1 . ASN D 4 255 ? 159.668 200.460 169.696 1.00 57.10  ? 255 ASN B OD1 1 
ATOM   6072 N ND2 . ASN D 4 255 ? 158.395 200.775 171.517 1.00 57.10  ? 255 ASN B ND2 1 
ATOM   6073 N N   . ASN D 4 256 ? 160.232 195.869 172.949 1.00 53.82  ? 256 ASN B N   1 
ATOM   6074 C CA  . ASN D 4 256 ? 161.056 194.878 173.623 1.00 53.82  ? 256 ASN B CA  1 
ATOM   6075 C C   . ASN D 4 256 ? 161.900 194.111 172.613 1.00 53.82  ? 256 ASN B C   1 
ATOM   6076 O O   . ASN D 4 256 ? 161.450 193.791 171.509 1.00 53.82  ? 256 ASN B O   1 
ATOM   6077 C CB  . ASN D 4 256 ? 160.190 193.894 174.410 1.00 53.82  ? 256 ASN B CB  1 
ATOM   6078 C CG  . ASN D 4 256 ? 159.901 194.362 175.819 1.00 53.82  ? 256 ASN B CG  1 
ATOM   6079 O OD1 . ASN D 4 256 ? 158.743 194.482 176.218 1.00 53.82  ? 256 ASN B OD1 1 
ATOM   6080 N ND2 . ASN D 4 256 ? 160.952 194.626 176.584 1.00 53.82  ? 256 ASN B ND2 1 
ATOM   6081 N N   . LYS D 4 257 ? 163.140 193.815 173.003 1.00 51.24  ? 257 LYS B N   1 
ATOM   6082 C CA  . LYS D 4 257 ? 164.017 192.991 172.182 1.00 51.24  ? 257 LYS B CA  1 
ATOM   6083 C C   . LYS D 4 257 ? 163.538 191.551 172.082 1.00 51.24  ? 257 LYS B C   1 
ATOM   6084 O O   . LYS D 4 257 ? 163.924 190.848 171.142 1.00 51.24  ? 257 LYS B O   1 
ATOM   6085 C CB  . LYS D 4 257 ? 165.441 193.026 172.742 1.00 51.24  ? 257 LYS B CB  1 
ATOM   6086 C CG  . LYS D 4 257 ? 165.569 192.454 174.145 1.00 51.24  ? 257 LYS B CG  1 
ATOM   6087 C CD  . LYS D 4 257 ? 166.813 192.978 174.844 1.00 51.24  ? 257 LYS B CD  1 
ATOM   6088 C CE  . LYS D 4 257 ? 167.079 192.230 176.140 1.00 51.24  ? 257 LYS B CE  1 
ATOM   6089 N NZ  . LYS D 4 257 ? 167.796 190.948 175.896 1.00 51.24  ? 257 LYS B NZ  1 
ATOM   6090 N N   . TRP D 4 258 ? 162.704 191.107 173.018 1.00 52.69  ? 258 TRP B N   1 
ATOM   6091 C CA  . TRP D 4 258 ? 162.117 189.778 172.985 1.00 52.69  ? 258 TRP B CA  1 
ATOM   6092 C C   . TRP D 4 258 ? 160.988 189.649 171.978 1.00 52.69  ? 258 TRP B C   1 
ATOM   6093 O O   . TRP D 4 258 ? 160.646 188.525 171.592 1.00 52.69  ? 258 TRP B O   1 
ATOM   6094 C CB  . TRP D 4 258 ? 161.589 189.415 174.373 1.00 52.69  ? 258 TRP B CB  1 
ATOM   6095 C CG  . TRP D 4 258 ? 162.567 189.660 175.478 1.00 52.69  ? 258 TRP B CG  1 
ATOM   6096 C CD1 . TRP D 4 258 ? 162.458 190.578 176.480 1.00 52.69  ? 258 TRP B CD1 1 
ATOM   6097 C CD2 . TRP D 4 258 ? 163.795 188.961 175.707 1.00 52.69  ? 258 TRP B CD2 1 
ATOM   6098 N NE1 . TRP D 4 258 ? 163.547 190.502 177.312 1.00 52.69  ? 258 TRP B NE1 1 
ATOM   6099 C CE2 . TRP D 4 258 ? 164.383 189.516 176.859 1.00 52.69  ? 258 TRP B CE2 1 
ATOM   6100 C CE3 . TRP D 4 258 ? 164.456 187.922 175.045 1.00 52.69  ? 258 TRP B CE3 1 
ATOM   6101 C CZ2 . TRP D 4 258 ? 165.598 189.067 177.366 1.00 52.69  ? 258 TRP B CZ2 1 
ATOM   6102 C CZ3 . TRP D 4 258 ? 165.664 187.479 175.549 1.00 52.69  ? 258 TRP B CZ3 1 
ATOM   6103 C CH2 . TRP D 4 258 ? 166.223 188.051 176.697 1.00 52.69  ? 258 TRP B CH2 1 
ATOM   6104 N N   . PHE D 4 259 ? 160.407 190.763 171.545 1.00 47.95  ? 259 PHE B N   1 
ATOM   6105 C CA  . PHE D 4 259 ? 159.246 190.734 170.667 1.00 47.95  ? 259 PHE B CA  1 
ATOM   6106 C C   . PHE D 4 259 ? 159.531 191.453 169.356 1.00 47.95  ? 259 PHE B C   1 
ATOM   6107 O O   . PHE D 4 259 ? 158.767 192.332 168.948 1.00 47.95  ? 259 PHE B O   1 
ATOM   6108 C CB  . PHE D 4 259 ? 158.032 191.343 171.369 1.00 47.95  ? 259 PHE B CB  1 
ATOM   6109 C CG  . PHE D 4 259 ? 157.627 190.611 172.614 1.00 47.95  ? 259 PHE B CG  1 
ATOM   6110 C CD1 . PHE D 4 259 ? 156.859 189.463 172.536 1.00 47.95  ? 259 PHE B CD1 1 
ATOM   6111 C CD2 . PHE D 4 259 ? 158.018 191.065 173.859 1.00 47.95  ? 259 PHE B CD2 1 
ATOM   6112 C CE1 . PHE D 4 259 ? 156.484 188.785 173.679 1.00 47.95  ? 259 PHE B CE1 1 
ATOM   6113 C CE2 . PHE D 4 259 ? 157.647 190.391 175.003 1.00 47.95  ? 259 PHE B CE2 1 
ATOM   6114 C CZ  . PHE D 4 259 ? 156.879 189.251 174.913 1.00 47.95  ? 259 PHE B CZ  1 
ATOM   6115 N N   . THR D 4 260 ? 160.654 191.117 168.719 1.00 49.74  ? 260 THR B N   1 
ATOM   6116 C CA  . THR D 4 260 ? 160.967 191.680 167.409 1.00 49.74  ? 260 THR B CA  1 
ATOM   6117 C C   . THR D 4 260 ? 159.965 191.224 166.354 1.00 49.74  ? 260 THR B C   1 
ATOM   6118 O O   . THR D 4 260 ? 159.569 192.009 165.485 1.00 49.74  ? 260 THR B O   1 
ATOM   6119 C CB  . THR D 4 260 ? 162.391 191.294 167.006 1.00 49.74  ? 260 THR B CB  1 
ATOM   6120 O OG1 . THR D 4 260 ? 163.308 191.728 168.017 1.00 49.74  ? 260 THR B OG1 1 
ATOM   6121 C CG2 . THR D 4 260 ? 162.779 191.937 165.684 1.00 49.74  ? 260 THR B CG2 1 
ATOM   6122 N N   . ASP D 4 261 ? 159.525 189.972 166.421 1.00 49.21  ? 261 ASP B N   1 
ATOM   6123 C CA  . ASP D 4 261 ? 158.633 189.403 165.418 1.00 49.21  ? 261 ASP B CA  1 
ATOM   6124 C C   . ASP D 4 261 ? 157.408 188.757 166.057 1.00 49.21  ? 261 ASP B C   1 
ATOM   6125 O O   . ASP D 4 261 ? 157.022 187.638 165.712 1.00 49.21  ? 261 ASP B O   1 
ATOM   6126 C CB  . ASP D 4 261 ? 159.375 188.396 164.545 1.00 49.21  ? 261 ASP B CB  1 
ATOM   6127 C CG  . ASP D 4 261 ? 158.721 188.206 163.190 1.00 49.21  ? 261 ASP B CG  1 
ATOM   6128 O OD1 . ASP D 4 261 ? 157.716 188.893 162.914 1.00 49.21  ? 261 ASP B OD1 1 
ATOM   6129 O OD2 . ASP D 4 261 ? 159.207 187.364 162.405 1.00 49.21  ? 261 ASP B OD2 1 
ATOM   6130 N N   . THR D 4 262 ? 156.778 189.453 166.999 1.00 36.49  ? 262 THR B N   1 
ATOM   6131 C CA  . THR D 4 262 ? 155.542 188.994 167.625 1.00 36.49  ? 262 THR B CA  1 
ATOM   6132 C C   . THR D 4 262 ? 154.459 190.017 167.315 1.00 36.49  ? 262 THR B C   1 
ATOM   6133 O O   . THR D 4 262 ? 154.449 191.107 167.894 1.00 36.49  ? 262 THR B O   1 
ATOM   6134 C CB  . THR D 4 262 ? 155.713 188.818 169.133 1.00 36.49  ? 262 THR B CB  1 
ATOM   6135 O OG1 . THR D 4 262 ? 156.876 188.023 169.397 1.00 36.49  ? 262 THR B OG1 1 
ATOM   6136 C CG2 . THR D 4 262 ? 154.497 188.129 169.725 1.00 36.49  ? 262 THR B CG2 1 
ATOM   6137 N N   . SER D 4 263 ? 153.551 189.664 166.410 1.00 26.12  ? 263 SER B N   1 
ATOM   6138 C CA  . SER D 4 263 ? 152.552 190.612 165.941 1.00 26.12  ? 263 SER B CA  1 
ATOM   6139 C C   . SER D 4 263 ? 151.536 190.924 167.034 1.00 26.12  ? 263 SER B C   1 
ATOM   6140 O O   . SER D 4 263 ? 150.952 190.027 167.643 1.00 26.12  ? 263 SER B O   1 
ATOM   6141 C CB  . SER D 4 263 ? 151.837 190.053 164.714 1.00 26.12  ? 263 SER B CB  1 
ATOM   6142 O OG  . SER D 4 263 ? 152.745 189.863 163.645 1.00 26.12  ? 263 SER B OG  1 
ATOM   6143 N N   . ILE D 4 264 ? 151.299 192.214 167.250 1.00 21.01  ? 264 ILE B N   1 
ATOM   6144 C CA  . ILE D 4 264 ? 150.410 192.694 168.303 1.00 21.01  ? 264 ILE B CA  1 
ATOM   6145 C C   . ILE D 4 264 ? 148.988 192.701 167.763 1.00 21.01  ? 264 ILE B C   1 
ATOM   6146 O O   . ILE D 4 264 ? 148.721 193.274 166.702 1.00 21.01  ? 264 ILE B O   1 
ATOM   6147 C CB  . ILE D 4 264 ? 150.803 194.093 168.811 1.00 21.01  ? 264 ILE B CB  1 
ATOM   6148 C CG1 . ILE D 4 264 ? 152.155 194.090 169.524 1.00 21.01  ? 264 ILE B CG1 1 
ATOM   6149 C CG2 . ILE D 4 264 ? 149.738 194.654 169.736 1.00 21.01  ? 264 ILE B CG2 1 
ATOM   6150 C CD1 . ILE D 4 264 ? 153.318 194.388 168.654 1.00 21.01  ? 264 ILE B CD1 1 
ATOM   6151 N N   . ILE D 4 265 ? 148.080 192.051 168.475 1.00 20.36  ? 265 ILE B N   1 
ATOM   6152 C CA  . ILE D 4 265 ? 146.653 192.181 168.217 1.00 20.36  ? 265 ILE B CA  1 
ATOM   6153 C C   . ILE D 4 265 ? 146.158 193.247 169.185 1.00 20.36  ? 265 ILE B C   1 
ATOM   6154 O O   . ILE D 4 265 ? 145.704 192.949 170.286 1.00 20.36  ? 265 ILE B O   1 
ATOM   6155 C CB  . ILE D 4 265 ? 145.915 190.860 168.401 1.00 20.36  ? 265 ILE B CB  1 
ATOM   6156 C CG1 . ILE D 4 265 ? 146.681 189.694 167.798 1.00 20.36  ? 265 ILE B CG1 1 
ATOM   6157 C CG2 . ILE D 4 265 ? 144.534 190.935 167.792 1.00 20.36  ? 265 ILE B CG2 1 
ATOM   6158 C CD1 . ILE D 4 265 ? 146.136 188.363 168.256 1.00 20.36  ? 265 ILE B CD1 1 
ATOM   6159 N N   . LEU D 4 266 ? 146.249 194.503 168.775 1.00 27.82  ? 266 LEU B N   1 
ATOM   6160 C CA  . LEU D 4 266 ? 145.706 195.588 169.575 1.00 27.82  ? 266 LEU B CA  1 
ATOM   6161 C C   . LEU D 4 266 ? 144.187 195.510 169.571 1.00 27.82  ? 266 LEU B C   1 
ATOM   6162 O O   . LEU D 4 266 ? 143.581 195.255 168.531 1.00 27.82  ? 266 LEU B O   1 
ATOM   6163 C CB  . LEU D 4 266 ? 146.178 196.930 169.024 1.00 27.82  ? 266 LEU B CB  1 
ATOM   6164 C CG  . LEU D 4 266 ? 145.817 198.198 169.787 1.00 27.82  ? 266 LEU B CG  1 
ATOM   6165 C CD1 . LEU D 4 266 ? 146.552 198.264 171.096 1.00 27.82  ? 266 LEU B CD1 1 
ATOM   6166 C CD2 . LEU D 4 266 ? 146.156 199.402 168.937 1.00 27.82  ? 266 LEU B CD2 1 
ATOM   6167 N N   . PHE D 4 267 ? 143.574 195.693 170.733 1.00 33.14  ? 267 PHE B N   1 
ATOM   6168 C CA  . PHE D 4 267 ? 142.124 195.718 170.856 1.00 33.14  ? 267 PHE B CA  1 
ATOM   6169 C C   . PHE D 4 267 ? 141.695 197.033 171.482 1.00 33.14  ? 267 PHE B C   1 
ATOM   6170 O O   . PHE D 4 267 ? 142.283 197.473 172.475 1.00 33.14  ? 267 PHE B O   1 
ATOM   6171 C CB  . PHE D 4 267 ? 141.604 194.556 171.705 1.00 33.14  ? 267 PHE B CB  1 
ATOM   6172 C CG  . PHE D 4 267 ? 141.493 193.258 170.967 1.00 33.14  ? 267 PHE B CG  1 
ATOM   6173 C CD1 . PHE D 4 267 ? 141.456 193.227 169.589 1.00 33.14  ? 267 PHE B CD1 1 
ATOM   6174 C CD2 . PHE D 4 267 ? 141.410 192.065 171.658 1.00 33.14  ? 267 PHE B CD2 1 
ATOM   6175 C CE1 . PHE D 4 267 ? 141.346 192.034 168.915 1.00 33.14  ? 267 PHE B CE1 1 
ATOM   6176 C CE2 . PHE D 4 267 ? 141.305 190.867 170.987 1.00 33.14  ? 267 PHE B CE2 1 
ATOM   6177 C CZ  . PHE D 4 267 ? 141.274 190.854 169.612 1.00 33.14  ? 267 PHE B CZ  1 
ATOM   6178 N N   . LEU D 4 268 ? 140.675 197.655 170.906 1.00 45.60  ? 268 LEU B N   1 
ATOM   6179 C CA  . LEU D 4 268 ? 140.041 198.839 171.477 1.00 45.60  ? 268 LEU B CA  1 
ATOM   6180 C C   . LEU D 4 268 ? 138.588 198.468 171.758 1.00 45.60  ? 268 LEU B C   1 
ATOM   6181 O O   . LEU D 4 268 ? 137.804 198.227 170.839 1.00 45.60  ? 268 LEU B O   1 
ATOM   6182 C CB  . LEU D 4 268 ? 140.164 200.040 170.544 1.00 45.60  ? 268 LEU B CB  1 
ATOM   6183 C CG  . LEU D 4 268 ? 141.571 200.303 170.000 1.00 45.60  ? 268 LEU B CG  1 
ATOM   6184 C CD1 . LEU D 4 268 ? 141.594 201.502 169.079 1.00 45.60  ? 268 LEU B CD1 1 
ATOM   6185 C CD2 . LEU D 4 268 ? 142.539 200.519 171.138 1.00 45.60  ? 268 LEU B CD2 1 
ATOM   6186 N N   . ASN D 4 269 ? 138.237 198.407 173.038 1.00 61.23  ? 269 ASN B N   1 
ATOM   6187 C CA  . ASN D 4 269 ? 136.928 197.939 173.455 1.00 61.23  ? 269 ASN B CA  1 
ATOM   6188 C C   . ASN D 4 269 ? 136.130 199.063 174.119 1.00 61.23  ? 269 ASN B C   1 
ATOM   6189 O O   . ASN D 4 269 ? 136.595 200.203 174.222 1.00 61.23  ? 269 ASN B O   1 
ATOM   6190 C CB  . ASN D 4 269 ? 137.087 196.721 174.368 1.00 61.23  ? 269 ASN B CB  1 
ATOM   6191 C CG  . ASN D 4 269 ? 138.165 196.910 175.412 1.00 61.23  ? 269 ASN B CG  1 
ATOM   6192 O OD1 . ASN D 4 269 ? 138.651 198.018 175.626 1.00 61.23  ? 269 ASN B OD1 1 
ATOM   6193 N ND2 . ASN D 4 269 ? 138.562 195.818 176.053 1.00 61.23  ? 269 ASN B ND2 1 
ATOM   6194 N N   . LYS D 4 270 ? 134.934 198.706 174.599 1.00 67.29  ? 270 LYS B N   1 
ATOM   6195 C CA  . LYS D 4 270 ? 133.887 199.586 175.149 1.00 67.29  ? 270 LYS B CA  1 
ATOM   6196 C C   . LYS D 4 270 ? 133.761 200.908 174.384 1.00 67.29  ? 270 LYS B C   1 
ATOM   6197 O O   . LYS D 4 270 ? 133.904 202.003 174.928 1.00 67.29  ? 270 LYS B O   1 
ATOM   6198 C CB  . LYS D 4 270 ? 134.054 199.826 176.660 1.00 67.29  ? 270 LYS B CB  1 
ATOM   6199 C CG  . LYS D 4 270 ? 135.406 200.281 177.185 1.00 67.29  ? 270 LYS B CG  1 
ATOM   6200 C CD  . LYS D 4 270 ? 135.428 200.289 178.702 1.00 67.29  ? 270 LYS B CD  1 
ATOM   6201 C CE  . LYS D 4 270 ? 135.343 198.881 179.258 1.00 67.29  ? 270 LYS B CE  1 
ATOM   6202 N NZ  . LYS D 4 270 ? 136.006 198.775 180.585 1.00 67.29  ? 270 LYS B NZ  1 
ATOM   6203 N N   . LYS D 4 271 ? 133.470 200.779 173.087 1.00 72.05  ? 271 LYS B N   1 
ATOM   6204 C CA  . LYS D 4 271 ? 133.161 201.952 172.277 1.00 72.05  ? 271 LYS B CA  1 
ATOM   6205 C C   . LYS D 4 271 ? 131.809 202.555 172.630 1.00 72.05  ? 271 LYS B C   1 
ATOM   6206 O O   . LYS D 4 271 ? 131.569 203.726 172.315 1.00 72.05  ? 271 LYS B O   1 
ATOM   6207 C CB  . LYS D 4 271 ? 133.168 201.594 170.791 1.00 72.05  ? 271 LYS B CB  1 
ATOM   6208 C CG  . LYS D 4 271 ? 134.499 201.120 170.247 1.00 72.05  ? 271 LYS B CG  1 
ATOM   6209 C CD  . LYS D 4 271 ? 134.397 200.834 168.756 1.00 72.05  ? 271 LYS B CD  1 
ATOM   6210 C CE  . LYS D 4 271 ? 133.269 199.855 168.452 1.00 72.05  ? 271 LYS B CE  1 
ATOM   6211 N NZ  . LYS D 4 271 ? 133.135 199.574 166.995 1.00 72.05  ? 271 LYS B NZ  1 
ATOM   6212 N N   . ASP D 4 272 ? 130.922 201.773 173.257 1.00 81.63  ? 272 ASP B N   1 
ATOM   6213 C CA  . ASP D 4 272 ? 129.571 202.244 173.555 1.00 81.63  ? 272 ASP B CA  1 
ATOM   6214 C C   . ASP D 4 272 ? 129.586 203.396 174.550 1.00 81.63  ? 272 ASP B C   1 
ATOM   6215 O O   . ASP D 4 272 ? 128.842 204.371 174.391 1.00 81.63  ? 272 ASP B O   1 
ATOM   6216 C CB  . ASP D 4 272 ? 128.721 201.090 174.086 1.00 81.63  ? 272 ASP B CB  1 
ATOM   6217 N N   . LEU D 4 273 ? 130.426 203.308 175.581 1.00 82.82  ? 273 LEU B N   1 
ATOM   6218 C CA  . LEU D 4 273 ? 130.580 204.421 176.506 1.00 82.82  ? 273 LEU B CA  1 
ATOM   6219 C C   . LEU D 4 273 ? 131.334 205.588 175.887 1.00 82.82  ? 273 LEU B C   1 
ATOM   6220 O O   . LEU D 4 273 ? 131.193 206.719 176.361 1.00 82.82  ? 273 LEU B O   1 
ATOM   6221 C CB  . LEU D 4 273 ? 131.293 203.959 177.779 1.00 82.82  ? 273 LEU B CB  1 
ATOM   6222 C CG  . LEU D 4 273 ? 130.558 202.905 178.607 1.00 82.82  ? 273 LEU B CG  1 
ATOM   6223 C CD1 . LEU D 4 273 ? 131.412 202.448 179.778 1.00 82.82  ? 273 LEU B CD1 1 
ATOM   6224 C CD2 . LEU D 4 273 ? 129.222 203.445 179.091 1.00 82.82  ? 273 LEU B CD2 1 
ATOM   6225 N N   . PHE D 4 274 ? 132.118 205.341 174.838 1.00 79.61  ? 274 PHE B N   1 
ATOM   6226 C CA  . PHE D 4 274 ? 132.842 206.396 174.144 1.00 79.61  ? 274 PHE B CA  1 
ATOM   6227 C C   . PHE D 4 274 ? 131.955 207.198 173.201 1.00 79.61  ? 274 PHE B C   1 
ATOM   6228 O O   . PHE D 4 274 ? 132.363 208.279 172.763 1.00 79.61  ? 274 PHE B O   1 
ATOM   6229 C CB  . PHE D 4 274 ? 134.012 205.786 173.371 1.00 79.61  ? 274 PHE B CB  1 
ATOM   6230 C CG  . PHE D 4 274 ? 135.032 206.788 172.918 1.00 79.61  ? 274 PHE B CG  1 
ATOM   6231 C CD1 . PHE D 4 274 ? 135.671 207.607 173.832 1.00 79.61  ? 274 PHE B CD1 1 
ATOM   6232 C CD2 . PHE D 4 274 ? 135.357 206.907 171.577 1.00 79.61  ? 274 PHE B CD2 1 
ATOM   6233 C CE1 . PHE D 4 274 ? 136.614 208.530 173.414 1.00 79.61  ? 274 PHE B CE1 1 
ATOM   6234 C CE2 . PHE D 4 274 ? 136.300 207.828 171.156 1.00 79.61  ? 274 PHE B CE2 1 
ATOM   6235 C CZ  . PHE D 4 274 ? 136.928 208.637 172.076 1.00 79.61  ? 274 PHE B CZ  1 
ATOM   6236 N N   . GLU D 4 275 ? 130.758 206.701 172.886 1.00 85.03  ? 275 GLU B N   1 
ATOM   6237 C CA  . GLU D 4 275 ? 129.873 207.405 171.964 1.00 85.03  ? 275 GLU B CA  1 
ATOM   6238 C C   . GLU D 4 275 ? 129.329 208.685 172.586 1.00 85.03  ? 275 GLU B C   1 
ATOM   6239 O O   . GLU D 4 275 ? 129.326 209.744 171.948 1.00 85.03  ? 275 GLU B O   1 
ATOM   6240 C CB  . GLU D 4 275 ? 128.729 206.486 171.536 1.00 85.03  ? 275 GLU B CB  1 
ATOM   6241 C CG  . GLU D 4 275 ? 127.969 206.955 170.304 1.00 85.03  ? 275 GLU B CG  1 
ATOM   6242 C CD  . GLU D 4 275 ? 126.737 207.773 170.646 1.00 85.03  ? 275 GLU B CD  1 
ATOM   6243 O OE1 . GLU D 4 275 ? 126.227 207.642 171.778 1.00 85.03  ? 275 GLU B OE1 1 
ATOM   6244 O OE2 . GLU D 4 275 ? 126.272 208.542 169.778 1.00 85.03  ? 275 GLU B OE2 1 
ATOM   6245 N N   . GLU D 4 276 ? 128.856 208.610 173.827 1.00 85.62  ? 276 GLU B N   1 
ATOM   6246 C CA  . GLU D 4 276 ? 128.320 209.786 174.498 1.00 85.62  ? 276 GLU B CA  1 
ATOM   6247 C C   . GLU D 4 276 ? 129.371 210.569 175.272 1.00 85.62  ? 276 GLU B C   1 
ATOM   6248 O O   . GLU D 4 276 ? 129.154 211.754 175.549 1.00 85.62  ? 276 GLU B O   1 
ATOM   6249 C CB  . GLU D 4 276 ? 127.181 209.385 175.445 1.00 85.62  ? 276 GLU B CB  1 
ATOM   6250 C CG  . GLU D 4 276 ? 127.613 208.567 176.655 1.00 85.62  ? 276 GLU B CG  1 
ATOM   6251 C CD  . GLU D 4 276 ? 127.542 207.073 176.403 1.00 85.62  ? 276 GLU B CD  1 
ATOM   6252 O OE1 . GLU D 4 276 ? 127.379 206.676 175.231 1.00 85.62  ? 276 GLU B OE1 1 
ATOM   6253 O OE2 . GLU D 4 276 ? 127.657 206.298 177.377 1.00 85.62  ? 276 GLU B OE2 1 
ATOM   6254 N N   . LYS D 4 277 ? 130.499 209.953 175.616 1.00 89.48  ? 277 LYS B N   1 
ATOM   6255 C CA  . LYS D 4 277 ? 131.557 210.633 176.351 1.00 89.48  ? 277 LYS B CA  1 
ATOM   6256 C C   . LYS D 4 277 ? 132.409 211.522 175.462 1.00 89.48  ? 277 LYS B C   1 
ATOM   6257 O O   . LYS D 4 277 ? 133.227 212.289 175.978 1.00 89.48  ? 277 LYS B O   1 
ATOM   6258 C CB  . LYS D 4 277 ? 132.454 209.614 177.056 1.00 89.48  ? 277 LYS B CB  1 
ATOM   6259 C CG  . LYS D 4 277 ? 132.031 209.287 178.474 1.00 89.48  ? 277 LYS B CG  1 
ATOM   6260 C CD  . LYS D 4 277 ? 133.051 208.388 179.150 1.00 89.48  ? 277 LYS B CD  1 
ATOM   6261 C CE  . LYS D 4 277 ? 134.261 209.175 179.620 1.00 89.48  ? 277 LYS B CE  1 
ATOM   6262 N NZ  . LYS D 4 277 ? 135.085 208.398 180.586 1.00 89.48  ? 277 LYS B NZ  1 
ATOM   6263 N N   . ILE D 4 278 ? 132.239 211.436 174.146 1.00 90.42  ? 278 ILE B N   1 
ATOM   6264 C CA  . ILE D 4 278 ? 132.935 212.317 173.221 1.00 90.42  ? 278 ILE B CA  1 
ATOM   6265 C C   . ILE D 4 278 ? 132.092 213.537 172.860 1.00 90.42  ? 278 ILE B C   1 
ATOM   6266 O O   . ILE D 4 278 ? 132.660 214.571 172.471 1.00 90.42  ? 278 ILE B O   1 
ATOM   6267 C CB  . ILE D 4 278 ? 133.365 211.546 171.951 1.00 90.42  ? 278 ILE B CB  1 
ATOM   6268 C CG1 . ILE D 4 278 ? 134.383 212.333 171.122 1.00 90.42  ? 278 ILE B CG1 1 
ATOM   6269 C CG2 . ILE D 4 278 ? 132.152 211.173 171.094 1.00 90.42  ? 278 ILE B CG2 1 
ATOM   6270 C CD1 . ILE D 4 278 ? 135.692 212.531 171.818 1.00 90.42  ? 278 ILE B CD1 1 
ATOM   6271 N N   . LYS D 4 279 ? 130.771 213.478 173.049 1.00 92.82  ? 279 LYS B N   1 
ATOM   6272 C CA  . LYS D 4 279 ? 129.892 214.588 172.703 1.00 92.82  ? 279 LYS B CA  1 
ATOM   6273 C C   . LYS D 4 279 ? 130.103 215.795 173.608 1.00 92.82  ? 279 LYS B C   1 
ATOM   6274 O O   . LYS D 4 279 ? 129.925 216.936 173.166 1.00 92.82  ? 279 LYS B O   1 
ATOM   6275 C CB  . LYS D 4 279 ? 128.435 214.137 172.782 1.00 92.82  ? 279 LYS B CB  1 
ATOM   6276 C CG  . LYS D 4 279 ? 128.031 213.154 171.705 1.00 92.82  ? 279 LYS B CG  1 
ATOM   6277 C CD  . LYS D 4 279 ? 126.609 212.685 171.926 1.00 92.82  ? 279 LYS B CD  1 
ATOM   6278 C CE  . LYS D 4 279 ? 126.175 211.698 170.863 1.00 92.82  ? 279 LYS B CE  1 
ATOM   6279 N NZ  . LYS D 4 279 ? 124.812 211.186 171.157 1.00 92.82  ? 279 LYS B NZ  1 
ATOM   6280 N N   . LYS D 4 280 ? 130.466 215.566 174.868 1.00 95.61  ? 280 LYS B N   1 
ATOM   6281 C CA  . LYS D 4 280 ? 130.644 216.642 175.837 1.00 95.61  ? 280 LYS B CA  1 
ATOM   6282 C C   . LYS D 4 280 ? 132.116 217.012 176.004 1.00 95.61  ? 280 LYS B C   1 
ATOM   6283 O O   . LYS D 4 280 ? 132.492 218.180 175.866 1.00 95.61  ? 280 LYS B O   1 
ATOM   6284 C CB  . LYS D 4 280 ? 130.027 216.230 177.178 1.00 95.61  ? 280 LYS B CB  1 
ATOM   6285 C CG  . LYS D 4 280 ? 128.602 216.722 177.382 1.00 95.61  ? 280 LYS B CG  1 
ATOM   6286 C CD  . LYS D 4 280 ? 127.606 215.912 176.562 1.00 95.61  ? 280 LYS B CD  1 
ATOM   6287 C CE  . LYS D 4 280 ? 127.566 214.456 176.988 1.00 95.61  ? 280 LYS B CE  1 
ATOM   6288 N NZ  . LYS D 4 280 ? 126.633 213.673 176.130 1.00 95.61  ? 280 LYS B NZ  1 
ATOM   6289 N N   . SER D 4 281 ? 132.956 216.025 176.305 1.00 93.07  ? 281 SER B N   1 
ATOM   6290 C CA  . SER D 4 281 ? 134.369 216.268 176.557 1.00 93.07  ? 281 SER B CA  1 
ATOM   6291 C C   . SER D 4 281 ? 135.163 216.112 175.268 1.00 93.07  ? 281 SER B C   1 
ATOM   6292 O O   . SER D 4 281 ? 135.142 215.027 174.671 1.00 93.07  ? 281 SER B O   1 
ATOM   6293 C CB  . SER D 4 281 ? 134.895 215.305 177.605 1.00 93.07  ? 281 SER B CB  1 
ATOM   6294 O OG  . SER D 4 281 ? 134.690 213.963 177.200 1.00 93.07  ? 281 SER B OG  1 
ATOM   6295 N N   . PRO D 4 282 ? 135.868 217.144 174.807 1.00 93.74  ? 282 PRO B N   1 
ATOM   6296 C CA  . PRO D 4 282 ? 136.728 216.979 173.628 1.00 93.74  ? 282 PRO B CA  1 
ATOM   6297 C C   . PRO D 4 282 ? 138.031 216.277 173.966 1.00 93.74  ? 282 PRO B C   1 
ATOM   6298 O O   . PRO D 4 282 ? 138.246 215.858 175.107 1.00 93.74  ? 282 PRO B O   1 
ATOM   6299 C CB  . PRO D 4 282 ? 136.972 218.420 173.172 1.00 93.74  ? 282 PRO B CB  1 
ATOM   6300 C CG  . PRO D 4 282 ? 136.884 219.212 174.423 1.00 93.74  ? 282 PRO B CG  1 
ATOM   6301 C CD  . PRO D 4 282 ? 135.861 218.533 175.296 1.00 93.74  ? 282 PRO B CD  1 
ATOM   6302 N N   . LEU D 4 283 ? 138.920 216.163 172.984 1.00 97.01  ? 283 LEU B N   1 
ATOM   6303 C CA  . LEU D 4 283 ? 140.211 215.524 173.204 1.00 97.01  ? 283 LEU B CA  1 
ATOM   6304 C C   . LEU D 4 283 ? 141.226 216.453 173.854 1.00 97.01  ? 283 LEU B C   1 
ATOM   6305 O O   . LEU D 4 283 ? 142.343 216.011 174.146 1.00 97.01  ? 283 LEU B O   1 
ATOM   6306 C CB  . LEU D 4 283 ? 140.787 215.000 171.884 1.00 97.01  ? 283 LEU B CB  1 
ATOM   6307 C CG  . LEU D 4 283 ? 140.246 213.693 171.289 1.00 97.01  ? 283 LEU B CG  1 
ATOM   6308 C CD1 . LEU D 4 283 ? 138.910 213.875 170.585 1.00 97.01  ? 283 LEU B CD1 1 
ATOM   6309 C CD2 . LEU D 4 283 ? 141.263 213.055 170.355 1.00 97.01  ? 283 LEU B CD2 1 
ATOM   6310 N N   . THR D 4 284 ? 140.869 217.720 174.082 1.00 99.54  ? 284 THR B N   1 
ATOM   6311 C CA  . THR D 4 284 ? 141.796 218.681 174.671 1.00 99.54  ? 284 THR B CA  1 
ATOM   6312 C C   . THR D 4 284 ? 142.160 218.341 176.109 1.00 99.54  ? 284 THR B C   1 
ATOM   6313 O O   . THR D 4 284 ? 143.203 218.795 176.591 1.00 99.54  ? 284 THR B O   1 
ATOM   6314 C CB  . THR D 4 284 ? 141.201 220.088 174.613 1.00 99.54  ? 284 THR B CB  1 
ATOM   6315 O OG1 . THR D 4 284 ? 139.959 220.111 175.326 1.00 99.54  ? 284 THR B OG1 1 
ATOM   6316 C CG2 . THR D 4 284 ? 140.957 220.498 173.171 1.00 99.54  ? 284 THR B CG2 1 
ATOM   6317 N N   . ILE D 4 285 ? 141.319 217.576 176.810 1.00 98.00  ? 285 ILE B N   1 
ATOM   6318 C CA  . ILE D 4 285 ? 141.699 217.072 178.126 1.00 98.00  ? 285 ILE B CA  1 
ATOM   6319 C C   . ILE D 4 285 ? 142.869 216.105 178.000 1.00 98.00  ? 285 ILE B C   1 
ATOM   6320 O O   . ILE D 4 285 ? 143.844 216.183 178.758 1.00 98.00  ? 285 ILE B O   1 
ATOM   6321 C CB  . ILE D 4 285 ? 140.497 216.413 178.838 1.00 98.00  ? 285 ILE B CB  1 
ATOM   6322 C CG1 . ILE D 4 285 ? 139.367 217.416 179.124 1.00 98.00  ? 285 ILE B CG1 1 
ATOM   6323 C CG2 . ILE D 4 285 ? 140.933 215.753 180.141 1.00 98.00  ? 285 ILE B CG2 1 
ATOM   6324 C CD1 . ILE D 4 285 ? 138.308 217.555 178.033 1.00 98.00  ? 285 ILE B CD1 1 
ATOM   6325 N N   . CYS D 4 286 ? 142.805 215.198 177.026 1.00 94.78  ? 286 CYS B N   1 
ATOM   6326 C CA  . CYS D 4 286 ? 143.849 214.198 176.846 1.00 94.78  ? 286 CYS B CA  1 
ATOM   6327 C C   . CYS D 4 286 ? 145.008 214.709 175.998 1.00 94.78  ? 286 CYS B C   1 
ATOM   6328 O O   . CYS D 4 286 ? 146.172 214.509 176.360 1.00 94.78  ? 286 CYS B O   1 
ATOM   6329 C CB  . CYS D 4 286 ? 143.258 212.935 176.214 1.00 94.78  ? 286 CYS B CB  1 
ATOM   6330 S SG  . CYS D 4 286 ? 144.250 211.449 176.465 1.00 94.78  ? 286 CYS B SG  1 
ATOM   6331 N N   . TYR D 4 287 ? 144.716 215.365 174.880 1.00 95.49  ? 287 TYR B N   1 
ATOM   6332 C CA  . TYR D 4 287 ? 145.746 215.873 173.974 1.00 95.49  ? 287 TYR B CA  1 
ATOM   6333 C C   . TYR D 4 287 ? 145.460 217.322 173.610 1.00 95.49  ? 287 TYR B C   1 
ATOM   6334 O O   . TYR D 4 287 ? 144.483 217.591 172.881 1.00 95.49  ? 287 TYR B O   1 
ATOM   6335 C CB  . TYR D 4 287 ? 145.832 215.025 172.708 1.00 95.49  ? 287 TYR B CB  1 
ATOM   6336 C CG  . TYR D 4 287 ? 145.739 213.540 172.945 1.00 95.49  ? 287 TYR B CG  1 
ATOM   6337 C CD1 . TYR D 4 287 ? 146.777 212.851 173.555 1.00 95.49  ? 287 TYR B CD1 1 
ATOM   6338 C CD2 . TYR D 4 287 ? 144.618 212.824 172.547 1.00 95.49  ? 287 TYR B CD2 1 
ATOM   6339 C CE1 . TYR D 4 287 ? 146.698 211.491 173.772 1.00 95.49  ? 287 TYR B CE1 1 
ATOM   6340 C CE2 . TYR D 4 287 ? 144.528 211.464 172.761 1.00 95.49  ? 287 TYR B CE2 1 
ATOM   6341 C CZ  . TYR D 4 287 ? 145.575 210.801 173.366 1.00 95.49  ? 287 TYR B CZ  1 
ATOM   6342 O OH  . TYR D 4 287 ? 145.493 209.446 173.579 1.00 95.49  ? 287 TYR B OH  1 
ATOM   6343 N N   . PRO D 4 288 ? 146.277 218.289 174.076 1.00 98.40  ? 288 PRO B N   1 
ATOM   6344 C CA  . PRO D 4 288 ? 146.184 219.671 173.592 1.00 98.40  ? 288 PRO B CA  1 
ATOM   6345 C C   . PRO D 4 288 ? 146.970 219.903 172.303 1.00 98.40  ? 288 PRO B C   1 
ATOM   6346 O O   . PRO D 4 288 ? 147.534 220.974 172.078 1.00 98.40  ? 288 PRO B O   1 
ATOM   6347 C CB  . PRO D 4 288 ? 146.762 220.478 174.762 1.00 98.40  ? 288 PRO B CB  1 
ATOM   6348 C CG  . PRO D 4 288 ? 147.725 219.550 175.416 1.00 98.40  ? 288 PRO B CG  1 
ATOM   6349 C CD  . PRO D 4 288 ? 147.233 218.146 175.188 1.00 98.40  ? 288 PRO B CD  1 
ATOM   6350 N N   . GLU D 4 289 ? 146.973 218.893 171.432 1.00 95.63  ? 289 GLU B N   1 
ATOM   6351 C CA  . GLU D 4 289 ? 147.619 219.011 170.131 1.00 95.63  ? 289 GLU B CA  1 
ATOM   6352 C C   . GLU D 4 289 ? 146.720 218.441 169.044 1.00 95.63  ? 289 GLU B C   1 
ATOM   6353 O O   . GLU D 4 289 ? 147.175 218.291 167.902 1.00 95.63  ? 289 GLU B O   1 
ATOM   6354 C CB  . GLU D 4 289 ? 148.982 218.294 170.126 1.00 95.63  ? 289 GLU B CB  1 
ATOM   6355 C CG  . GLU D 4 289 ? 148.909 216.765 170.155 1.00 95.63  ? 289 GLU B CG  1 
ATOM   6356 C CD  . GLU D 4 289 ? 148.911 216.184 171.553 1.00 95.63  ? 289 GLU B CD  1 
ATOM   6357 O OE1 . GLU D 4 289 ? 148.701 216.943 172.521 1.00 95.63  ? 289 GLU B OE1 1 
ATOM   6358 O OE2 . GLU D 4 289 ? 149.128 214.961 171.684 1.00 95.63  ? 289 GLU B OE2 1 
ATOM   6359 N N   . TYR D 4 290 ? 145.466 218.123 169.368 1.00 94.35  ? 290 TYR B N   1 
ATOM   6360 C CA  . TYR D 4 290 ? 144.558 217.491 168.419 1.00 94.35  ? 290 TYR B CA  1 
ATOM   6361 C C   . TYR D 4 290 ? 144.242 218.418 167.251 1.00 94.35  ? 290 TYR B C   1 
ATOM   6362 O O   . TYR D 4 290 ? 144.633 218.142 166.110 1.00 94.35  ? 290 TYR B O   1 
ATOM   6363 C CB  . TYR D 4 290 ? 143.286 217.066 169.154 1.00 94.35  ? 290 TYR B CB  1 
ATOM   6364 C CG  . TYR D 4 290 ? 142.243 216.425 168.280 1.00 94.35  ? 290 TYR B CG  1 
ATOM   6365 C CD1 . TYR D 4 290 ? 142.467 215.188 167.698 1.00 94.35  ? 290 TYR B CD1 1 
ATOM   6366 C CD2 . TYR D 4 290 ? 141.014 217.038 168.073 1.00 94.35  ? 290 TYR B CD2 1 
ATOM   6367 C CE1 . TYR D 4 290 ? 141.510 214.592 166.905 1.00 94.35  ? 290 TYR B CE1 1 
ATOM   6368 C CE2 . TYR D 4 290 ? 140.047 216.448 167.287 1.00 94.35  ? 290 TYR B CE2 1 
ATOM   6369 C CZ  . TYR D 4 290 ? 140.302 215.226 166.705 1.00 94.35  ? 290 TYR B CZ  1 
ATOM   6370 O OH  . TYR D 4 290 ? 139.342 214.636 165.921 1.00 94.35  ? 290 TYR B OH  1 
ATOM   6371 N N   . ALA D 4 291 ? 143.555 219.534 167.531 1.00 95.58  ? 291 ALA B N   1 
ATOM   6372 C CA  . ALA D 4 291 ? 143.241 220.582 166.549 1.00 95.58  ? 291 ALA B CA  1 
ATOM   6373 C C   . ALA D 4 291 ? 142.509 220.030 165.325 1.00 95.58  ? 291 ALA B C   1 
ATOM   6374 O O   . ALA D 4 291 ? 142.784 220.417 164.187 1.00 95.58  ? 291 ALA B O   1 
ATOM   6375 C CB  . ALA D 4 291 ? 144.500 221.347 166.131 1.00 95.58  ? 291 ALA B CB  1 
ATOM   6376 N N   . GLY D 4 292 ? 141.579 219.109 165.559 1.00 95.40  ? 292 GLY B N   1 
ATOM   6377 C CA  . GLY D 4 292 ? 140.796 218.538 164.482 1.00 95.40  ? 292 GLY B CA  1 
ATOM   6378 C C   . GLY D 4 292 ? 139.310 218.745 164.682 1.00 95.40  ? 292 GLY B C   1 
ATOM   6379 O O   . GLY D 4 292 ? 138.875 219.844 165.036 1.00 95.40  ? 292 GLY B O   1 
ATOM   6380 N N   . SER D 4 293 ? 138.520 217.697 164.467 1.00 91.57  ? 293 SER B N   1 
ATOM   6381 C CA  . SER D 4 293 ? 137.076 217.751 164.636 1.00 91.57  ? 293 SER B CA  1 
ATOM   6382 C C   . SER D 4 293 ? 136.687 216.905 165.838 1.00 91.57  ? 293 SER B C   1 
ATOM   6383 O O   . SER D 4 293 ? 137.125 215.756 165.963 1.00 91.57  ? 293 SER B O   1 
ATOM   6384 C CB  . SER D 4 293 ? 136.347 217.261 163.382 1.00 91.57  ? 293 SER B CB  1 
ATOM   6385 O OG  . SER D 4 293 ? 136.790 215.970 163.005 1.00 91.57  ? 293 SER B OG  1 
ATOM   6386 N N   . ASN D 4 294 ? 135.866 217.476 166.719 1.00 91.85  ? 294 ASN B N   1 
ATOM   6387 C CA  . ASN D 4 294 ? 135.402 216.781 167.918 1.00 91.85  ? 294 ASN B CA  1 
ATOM   6388 C C   . ASN D 4 294 ? 134.264 215.845 167.521 1.00 91.85  ? 294 ASN B C   1 
ATOM   6389 O O   . ASN D 4 294 ? 133.086 216.083 167.799 1.00 91.85  ? 294 ASN B O   1 
ATOM   6390 C CB  . ASN D 4 294 ? 134.961 217.779 168.981 1.00 91.85  ? 294 ASN B CB  1 
ATOM   6391 C CG  . ASN D 4 294 ? 134.784 217.141 170.344 1.00 91.85  ? 294 ASN B CG  1 
ATOM   6392 O OD1 . ASN D 4 294 ? 135.104 215.969 170.542 1.00 91.85  ? 294 ASN B OD1 1 
ATOM   6393 N ND2 . ASN D 4 294 ? 134.248 217.905 171.288 1.00 91.85  ? 294 ASN B ND2 1 
ATOM   6394 N N   . THR D 4 295 ? 134.631 214.754 166.854 1.00 88.04  ? 295 THR B N   1 
ATOM   6395 C CA  . THR D 4 295 ? 133.666 213.762 166.413 1.00 88.04  ? 295 THR B CA  1 
ATOM   6396 C C   . THR D 4 295 ? 134.215 212.372 166.698 1.00 88.04  ? 295 THR B C   1 
ATOM   6397 O O   . THR D 4 295 ? 135.404 212.190 166.967 1.00 88.04  ? 295 THR B O   1 
ATOM   6398 C CB  . THR D 4 295 ? 133.327 213.915 164.927 1.00 88.04  ? 295 THR B CB  1 
ATOM   6399 O OG1 . THR D 4 295 ? 132.337 212.946 164.560 1.00 88.04  ? 295 THR B OG1 1 
ATOM   6400 C CG2 . THR D 4 295 ? 134.561 213.709 164.079 1.00 88.04  ? 295 THR B CG2 1 
ATOM   6401 N N   . TYR D 4 296 ? 133.316 211.389 166.631 1.00 86.91  ? 296 TYR B N   1 
ATOM   6402 C CA  . TYR D 4 296 ? 133.637 210.022 167.032 1.00 86.91  ? 296 TYR B CA  1 
ATOM   6403 C C   . TYR D 4 296 ? 134.653 209.380 166.095 1.00 86.91  ? 296 TYR B C   1 
ATOM   6404 O O   . TYR D 4 296 ? 135.644 208.789 166.547 1.00 86.91  ? 296 TYR B O   1 
ATOM   6405 C CB  . TYR D 4 296 ? 132.346 209.203 167.082 1.00 86.91  ? 296 TYR B CB  1 
ATOM   6406 C CG  . TYR D 4 296 ? 132.522 207.737 167.390 1.00 86.91  ? 296 TYR B CG  1 
ATOM   6407 C CD1 . TYR D 4 296 ? 132.785 207.303 168.682 1.00 86.91  ? 296 TYR B CD1 1 
ATOM   6408 C CD2 . TYR D 4 296 ? 132.401 206.783 166.387 1.00 86.91  ? 296 TYR B CD2 1 
ATOM   6409 C CE1 . TYR D 4 296 ? 132.937 205.959 168.964 1.00 86.91  ? 296 TYR B CE1 1 
ATOM   6410 C CE2 . TYR D 4 296 ? 132.552 205.441 166.658 1.00 86.91  ? 296 TYR B CE2 1 
ATOM   6411 C CZ  . TYR D 4 296 ? 132.819 205.035 167.946 1.00 86.91  ? 296 TYR B CZ  1 
ATOM   6412 O OH  . TYR D 4 296 ? 132.968 203.697 168.215 1.00 86.91  ? 296 TYR B OH  1 
ATOM   6413 N N   . GLU D 4 297 ? 134.418 209.484 164.784 1.00 84.52  ? 297 GLU B N   1 
ATOM   6414 C CA  . GLU D 4 297 ? 135.257 208.790 163.812 1.00 84.52  ? 297 GLU B CA  1 
ATOM   6415 C C   . GLU D 4 297 ? 136.673 209.347 163.797 1.00 84.52  ? 297 GLU B C   1 
ATOM   6416 O O   . GLU D 4 297 ? 137.645 208.583 163.764 1.00 84.52  ? 297 GLU B O   1 
ATOM   6417 C CB  . GLU D 4 297 ? 134.630 208.882 162.422 1.00 84.52  ? 297 GLU B CB  1 
ATOM   6418 C CG  . GLU D 4 297 ? 135.457 208.236 161.327 1.00 84.52  ? 297 GLU B CG  1 
ATOM   6419 C CD  . GLU D 4 297 ? 135.505 206.726 161.450 1.00 84.52  ? 297 GLU B CD  1 
ATOM   6420 O OE1 . GLU D 4 297 ? 134.507 206.132 161.909 1.00 84.52  ? 297 GLU B OE1 1 
ATOM   6421 O OE2 . GLU D 4 297 ? 136.542 206.133 161.088 1.00 84.52  ? 297 GLU B OE2 1 
ATOM   6422 N N   . GLU D 4 298 ? 136.812 210.673 163.844 1.00 82.48  ? 298 GLU B N   1 
ATOM   6423 C CA  . GLU D 4 298 ? 138.142 211.269 163.849 1.00 82.48  ? 298 GLU B CA  1 
ATOM   6424 C C   . GLU D 4 298 ? 138.869 210.991 165.159 1.00 82.48  ? 298 GLU B C   1 
ATOM   6425 O O   . GLU D 4 298 ? 140.093 210.830 165.166 1.00 82.48  ? 298 GLU B O   1 
ATOM   6426 C CB  . GLU D 4 298 ? 138.051 212.770 163.589 1.00 82.48  ? 298 GLU B CB  1 
ATOM   6427 N N   . ALA D 4 299 ? 138.134 210.917 166.273 1.00 80.40  ? 299 ALA B N   1 
ATOM   6428 C CA  . ALA D 4 299 ? 138.758 210.565 167.547 1.00 80.40  ? 299 ALA B CA  1 
ATOM   6429 C C   . ALA D 4 299 ? 139.289 209.138 167.529 1.00 80.40  ? 299 ALA B C   1 
ATOM   6430 O O   . ALA D 4 299 ? 140.423 208.885 167.961 1.00 80.40  ? 299 ALA B O   1 
ATOM   6431 C CB  . ALA D 4 299 ? 137.765 210.747 168.692 1.00 80.40  ? 299 ALA B CB  1 
ATOM   6432 N N   . ALA D 4 300 ? 138.486 208.197 167.023 1.00 74.76  ? 300 ALA B N   1 
ATOM   6433 C CA  . ALA D 4 300 ? 138.943 206.815 166.913 1.00 74.76  ? 300 ALA B CA  1 
ATOM   6434 C C   . ALA D 4 300 ? 140.127 206.701 165.962 1.00 74.76  ? 300 ALA B C   1 
ATOM   6435 O O   . ALA D 4 300 ? 141.087 205.971 166.239 1.00 74.76  ? 300 ALA B O   1 
ATOM   6436 C CB  . ALA D 4 300 ? 137.797 205.918 166.453 1.00 74.76  ? 300 ALA B CB  1 
ATOM   6437 N N   . ALA D 4 301 ? 140.089 207.438 164.848 1.00 76.77  ? 301 ALA B N   1 
ATOM   6438 C CA  . ALA D 4 301 ? 141.187 207.404 163.888 1.00 76.77  ? 301 ALA B CA  1 
ATOM   6439 C C   . ALA D 4 301 ? 142.458 208.014 164.466 1.00 76.77  ? 301 ALA B C   1 
ATOM   6440 O O   . ALA D 4 301 ? 143.562 207.548 164.171 1.00 76.77  ? 301 ALA B O   1 
ATOM   6441 C CB  . ALA D 4 301 ? 140.784 208.127 162.604 1.00 76.77  ? 301 ALA B CB  1 
ATOM   6442 N N   . TYR D 4 302 ? 142.330 209.044 165.303 1.00 82.04  ? 302 TYR B N   1 
ATOM   6443 C CA  . TYR D 4 302 ? 143.518 209.667 165.875 1.00 82.04  ? 302 TYR B CA  1 
ATOM   6444 C C   . TYR D 4 302 ? 144.126 208.797 166.969 1.00 82.04  ? 302 TYR B C   1 
ATOM   6445 O O   . TYR D 4 302 ? 145.354 208.742 167.112 1.00 82.04  ? 302 TYR B O   1 
ATOM   6446 C CB  . TYR D 4 302 ? 143.175 211.060 166.398 1.00 82.04  ? 302 TYR B CB  1 
ATOM   6447 C CG  . TYR D 4 302 ? 144.382 211.930 166.662 1.00 82.04  ? 302 TYR B CG  1 
ATOM   6448 C CD1 . TYR D 4 302 ? 145.244 212.281 165.631 1.00 82.04  ? 302 TYR B CD1 1 
ATOM   6449 C CD2 . TYR D 4 302 ? 144.636 212.435 167.928 1.00 82.04  ? 302 TYR B CD2 1 
ATOM   6450 C CE1 . TYR D 4 302 ? 146.344 213.084 165.862 1.00 82.04  ? 302 TYR B CE1 1 
ATOM   6451 C CE2 . TYR D 4 302 ? 145.731 213.244 168.168 1.00 82.04  ? 302 TYR B CE2 1 
ATOM   6452 C CZ  . TYR D 4 302 ? 146.582 213.564 167.133 1.00 82.04  ? 302 TYR B CZ  1 
ATOM   6453 O OH  . TYR D 4 302 ? 147.673 214.367 167.368 1.00 82.04  ? 302 TYR B OH  1 
ATOM   6454 N N   . ILE D 4 303 ? 143.288 208.100 167.742 1.00 75.47  ? 303 ILE B N   1 
ATOM   6455 C CA  . ILE D 4 303 ? 143.811 207.126 168.699 1.00 75.47  ? 303 ILE B CA  1 
ATOM   6456 C C   . ILE D 4 303 ? 144.498 205.975 167.968 1.00 75.47  ? 303 ILE B C   1 
ATOM   6457 O O   . ILE D 4 303 ? 145.572 205.509 168.377 1.00 75.47  ? 303 ILE B O   1 
ATOM   6458 C CB  . ILE D 4 303 ? 142.681 206.638 169.624 1.00 75.47  ? 303 ILE B CB  1 
ATOM   6459 C CG1 . ILE D 4 303 ? 142.171 207.797 170.483 1.00 75.47  ? 303 ILE B CG1 1 
ATOM   6460 C CG2 . ILE D 4 303 ? 143.156 205.501 170.512 1.00 75.47  ? 303 ILE B CG2 1 
ATOM   6461 C CD1 . ILE D 4 303 ? 141.148 207.394 171.524 1.00 75.47  ? 303 ILE B CD1 1 
ATOM   6462 N N   . GLN D 4 304 ? 143.896 205.520 166.862 1.00 69.76  ? 304 GLN B N   1 
ATOM   6463 C CA  . GLN D 4 304 ? 144.525 204.540 165.980 1.00 69.76  ? 304 GLN B CA  1 
ATOM   6464 C C   . GLN D 4 304 ? 145.886 205.018 165.488 1.00 69.76  ? 304 GLN B C   1 
ATOM   6465 O O   . GLN D 4 304 ? 146.859 204.257 165.494 1.00 69.76  ? 304 GLN B O   1 
ATOM   6466 C CB  . GLN D 4 304 ? 143.607 204.281 164.785 1.00 69.76  ? 304 GLN B CB  1 
ATOM   6467 C CG  . GLN D 4 304 ? 144.084 203.230 163.806 1.00 69.76  ? 304 GLN B CG  1 
ATOM   6468 C CD  . GLN D 4 304 ? 144.000 201.849 164.384 1.00 69.76  ? 304 GLN B CD  1 
ATOM   6469 O OE1 . GLN D 4 304 ? 143.050 201.532 165.093 1.00 69.76  ? 304 GLN B OE1 1 
ATOM   6470 N NE2 . GLN D 4 304 ? 144.971 201.007 164.066 1.00 69.76  ? 304 GLN B NE2 1 
ATOM   6471 N N   . CYS D 4 305 ? 145.967 206.280 165.062 1.00 76.89  ? 305 CYS B N   1 
ATOM   6472 C CA  . CYS D 4 305 ? 147.208 206.816 164.514 1.00 76.89  ? 305 CYS B CA  1 
ATOM   6473 C C   . CYS D 4 305 ? 148.280 206.956 165.587 1.00 76.89  ? 305 CYS B C   1 
ATOM   6474 O O   . CYS D 4 305 ? 149.466 206.748 165.311 1.00 76.89  ? 305 CYS B O   1 
ATOM   6475 C CB  . CYS D 4 305 ? 146.940 208.162 163.843 1.00 76.89  ? 305 CYS B CB  1 
ATOM   6476 S SG  . CYS D 4 305 ? 148.369 208.879 163.000 1.00 76.89  ? 305 CYS B SG  1 
ATOM   6477 N N   . GLN D 4 306 ? 147.889 207.329 166.808 1.00 79.47  ? 306 GLN B N   1 
ATOM   6478 C CA  . GLN D 4 306 ? 148.859 207.367 167.899 1.00 79.47  ? 306 GLN B CA  1 
ATOM   6479 C C   . GLN D 4 306 ? 149.376 205.974 168.232 1.00 79.47  ? 306 GLN B C   1 
ATOM   6480 O O   . GLN D 4 306 ? 150.575 205.793 168.472 1.00 79.47  ? 306 GLN B O   1 
ATOM   6481 C CB  . GLN D 4 306 ? 148.255 208.001 169.148 1.00 79.47  ? 306 GLN B CB  1 
ATOM   6482 C CG  . GLN D 4 306 ? 147.960 209.472 169.045 1.00 79.47  ? 306 GLN B CG  1 
ATOM   6483 C CD  . GLN D 4 306 ? 147.344 210.002 170.318 1.00 79.47  ? 306 GLN B CD  1 
ATOM   6484 O OE1 . GLN D 4 306 ? 147.819 209.711 171.414 1.00 79.47  ? 306 GLN B OE1 1 
ATOM   6485 N NE2 . GLN D 4 306 ? 146.280 210.774 170.183 1.00 79.47  ? 306 GLN B NE2 1 
ATOM   6486 N N   . PHE D 4 307 ? 148.486 204.977 168.258 1.00 69.07  ? 307 PHE B N   1 
ATOM   6487 C CA  . PHE D 4 307 ? 148.918 203.638 168.649 1.00 69.07  ? 307 PHE B CA  1 
ATOM   6488 C C   . PHE D 4 307 ? 149.754 202.962 167.568 1.00 69.07  ? 307 PHE B C   1 
ATOM   6489 O O   . PHE D 4 307 ? 150.701 202.236 167.890 1.00 69.07  ? 307 PHE B O   1 
ATOM   6490 C CB  . PHE D 4 307 ? 147.708 202.780 169.011 1.00 69.07  ? 307 PHE B CB  1 
ATOM   6491 C CG  . PHE D 4 307 ? 147.319 202.873 170.455 1.00 69.07  ? 307 PHE B CG  1 
ATOM   6492 C CD1 . PHE D 4 307 ? 148.156 202.383 171.442 1.00 69.07  ? 307 PHE B CD1 1 
ATOM   6493 C CD2 . PHE D 4 307 ? 146.121 203.453 170.828 1.00 69.07  ? 307 PHE B CD2 1 
ATOM   6494 C CE1 . PHE D 4 307 ? 147.804 202.467 172.778 1.00 69.07  ? 307 PHE B CE1 1 
ATOM   6495 C CE2 . PHE D 4 307 ? 145.762 203.541 172.162 1.00 69.07  ? 307 PHE B CE2 1 
ATOM   6496 C CZ  . PHE D 4 307 ? 146.605 203.047 173.137 1.00 69.07  ? 307 PHE B CZ  1 
ATOM   6497 N N   . GLU D 4 308 ? 149.431 203.184 166.294 1.00 66.11  ? 308 GLU B N   1 
ATOM   6498 C CA  . GLU D 4 308 ? 150.200 202.556 165.226 1.00 66.11  ? 308 GLU B CA  1 
ATOM   6499 C C   . GLU D 4 308 ? 151.592 203.157 165.094 1.00 66.11  ? 308 GLU B C   1 
ATOM   6500 O O   . GLU D 4 308 ? 152.545 202.438 164.778 1.00 66.11  ? 308 GLU B O   1 
ATOM   6501 C CB  . GLU D 4 308 ? 149.456 202.673 163.900 1.00 66.11  ? 308 GLU B CB  1 
ATOM   6502 C CG  . GLU D 4 308 ? 148.212 201.824 163.824 1.00 66.11  ? 308 GLU B CG  1 
ATOM   6503 C CD  . GLU D 4 308 ? 148.522 200.349 163.815 1.00 66.11  ? 308 GLU B CD  1 
ATOM   6504 O OE1 . GLU D 4 308 ? 149.573 199.970 163.259 1.00 66.11  ? 308 GLU B OE1 1 
ATOM   6505 O OE2 . GLU D 4 308 ? 147.721 199.569 164.370 1.00 66.11  ? 308 GLU B OE2 1 
ATOM   6506 N N   . ASP D 4 309 ? 151.735 204.465 165.324 1.00 69.56  ? 309 ASP B N   1 
ATOM   6507 C CA  . ASP D 4 309 ? 153.041 205.104 165.213 1.00 69.56  ? 309 ASP B CA  1 
ATOM   6508 C C   . ASP D 4 309 ? 153.955 204.800 166.393 1.00 69.56  ? 309 ASP B C   1 
ATOM   6509 O O   . ASP D 4 309 ? 155.138 205.152 166.339 1.00 69.56  ? 309 ASP B O   1 
ATOM   6510 C CB  . ASP D 4 309 ? 152.883 206.618 165.058 1.00 69.56  ? 309 ASP B CB  1 
ATOM   6511 C CG  . ASP D 4 309 ? 152.126 206.999 163.799 1.00 69.56  ? 309 ASP B CG  1 
ATOM   6512 O OD1 . ASP D 4 309 ? 151.854 206.103 162.972 1.00 69.56  ? 309 ASP B OD1 1 
ATOM   6513 O OD2 . ASP D 4 309 ? 151.804 208.194 163.635 1.00 69.56  ? 309 ASP B OD2 1 
ATOM   6514 N N   . LEU D 4 310 ? 153.441 204.170 167.452 1.00 62.91  ? 310 LEU B N   1 
ATOM   6515 C CA  . LEU D 4 310 ? 154.288 203.710 168.545 1.00 62.91  ? 310 LEU B CA  1 
ATOM   6516 C C   . LEU D 4 310 ? 155.238 202.599 168.121 1.00 62.91  ? 310 LEU B C   1 
ATOM   6517 O O   . LEU D 4 310 ? 156.301 202.449 168.733 1.00 62.91  ? 310 LEU B O   1 
ATOM   6518 C CB  . LEU D 4 310 ? 153.422 203.236 169.712 1.00 62.91  ? 310 LEU B CB  1 
ATOM   6519 C CG  . LEU D 4 310 ? 152.762 204.348 170.527 1.00 62.91  ? 310 LEU B CG  1 
ATOM   6520 C CD1 . LEU D 4 310 ? 151.567 203.820 171.293 1.00 62.91  ? 310 LEU B CD1 1 
ATOM   6521 C CD2 . LEU D 4 310 ? 153.773 204.959 171.474 1.00 62.91  ? 310 LEU B CD2 1 
ATOM   6522 N N   . ASN D 4 311 ? 154.885 201.831 167.094 1.00 57.21  ? 311 ASN B N   1 
ATOM   6523 C CA  . ASN D 4 311 ? 155.759 200.800 166.552 1.00 57.21  ? 311 ASN B CA  1 
ATOM   6524 C C   . ASN D 4 311 ? 156.927 201.462 165.834 1.00 57.21  ? 311 ASN B C   1 
ATOM   6525 O O   . ASN D 4 311 ? 156.725 202.276 164.928 1.00 57.21  ? 311 ASN B O   1 
ATOM   6526 C CB  . ASN D 4 311 ? 154.972 199.904 165.601 1.00 57.21  ? 311 ASN B CB  1 
ATOM   6527 C CG  . ASN D 4 311 ? 155.762 198.704 165.131 1.00 57.21  ? 311 ASN B CG  1 
ATOM   6528 O OD1 . ASN D 4 311 ? 156.851 198.416 165.632 1.00 57.21  ? 311 ASN B OD1 1 
ATOM   6529 N ND2 . ASN D 4 311 ? 155.211 197.988 164.157 1.00 57.21  ? 311 ASN B ND2 1 
ATOM   6530 N N   . LYS D 4 312 ? 158.144 201.116 166.237 1.00 58.66  ? 312 LYS B N   1 
ATOM   6531 C CA  . LYS D 4 312 ? 159.339 201.724 165.671 1.00 58.66  ? 312 LYS B CA  1 
ATOM   6532 C C   . LYS D 4 312 ? 159.910 200.939 164.500 1.00 58.66  ? 312 LYS B C   1 
ATOM   6533 O O   . LYS D 4 312 ? 160.873 201.400 163.878 1.00 58.66  ? 312 LYS B O   1 
ATOM   6534 C CB  . LYS D 4 312 ? 160.412 201.884 166.753 1.00 58.66  ? 312 LYS B CB  1 
ATOM   6535 N N   . ARG D 4 313 ? 159.350 199.773 164.183 1.00 56.43  ? 313 ARG B N   1 
ATOM   6536 C CA  . ARG D 4 313 ? 159.850 198.965 163.073 1.00 56.43  ? 313 ARG B CA  1 
ATOM   6537 C C   . ARG D 4 313 ? 158.646 198.289 162.427 1.00 56.43  ? 313 ARG B C   1 
ATOM   6538 O O   . ARG D 4 313 ? 158.223 197.221 162.872 1.00 56.43  ? 313 ARG B O   1 
ATOM   6539 C CB  . ARG D 4 313 ? 160.872 197.943 163.554 1.00 56.43  ? 313 ARG B CB  1 
ATOM   6540 N N   . LYS D 4 314 ? 158.113 198.906 161.378 1.00 51.67  ? 314 LYS B N   1 
ATOM   6541 C CA  . LYS D 4 314 ? 156.891 198.426 160.748 1.00 51.67  ? 314 LYS B CA  1 
ATOM   6542 C C   . LYS D 4 314 ? 157.131 197.311 159.740 1.00 51.67  ? 314 LYS B C   1 
ATOM   6543 O O   . LYS D 4 314 ? 156.162 196.762 159.208 1.00 51.67  ? 314 LYS B O   1 
ATOM   6544 C CB  . LYS D 4 314 ? 156.163 199.586 160.061 1.00 51.67  ? 314 LYS B CB  1 
ATOM   6545 C CG  . LYS D 4 314 ? 155.073 200.231 160.905 1.00 51.67  ? 314 LYS B CG  1 
ATOM   6546 C CD  . LYS D 4 314 ? 155.653 201.244 161.880 1.00 51.67  ? 314 LYS B CD  1 
ATOM   6547 C CE  . LYS D 4 314 ? 156.228 202.445 161.144 1.00 51.67  ? 314 LYS B CE  1 
ATOM   6548 N NZ  . LYS D 4 314 ? 156.751 203.485 162.072 1.00 51.67  ? 314 LYS B NZ  1 
ATOM   6549 N N   . ASP D 4 315 ? 158.388 196.958 159.467 1.00 50.99  ? 315 ASP B N   1 
ATOM   6550 C CA  . ASP D 4 315 ? 158.673 195.961 158.440 1.00 50.99  ? 315 ASP B CA  1 
ATOM   6551 C C   . ASP D 4 315 ? 158.357 194.553 158.933 1.00 50.99  ? 315 ASP B C   1 
ATOM   6552 O O   . ASP D 4 315 ? 157.488 193.868 158.383 1.00 50.99  ? 315 ASP B O   1 
ATOM   6553 C CB  . ASP D 4 315 ? 160.134 196.065 158.000 1.00 50.99  ? 315 ASP B CB  1 
ATOM   6554 N N   . THR D 4 316 ? 159.054 194.106 159.975 1.00 48.30  ? 316 THR B N   1 
ATOM   6555 C CA  . THR D 4 316 ? 158.852 192.773 160.525 1.00 48.30  ? 316 THR B CA  1 
ATOM   6556 C C   . THR D 4 316 ? 157.695 192.701 161.512 1.00 48.30  ? 316 THR B C   1 
ATOM   6557 O O   . THR D 4 316 ? 157.271 191.595 161.867 1.00 48.30  ? 316 THR B O   1 
ATOM   6558 C CB  . THR D 4 316 ? 160.136 192.287 161.211 1.00 48.30  ? 316 THR B CB  1 
ATOM   6559 O OG1 . THR D 4 316 ? 159.955 190.945 161.680 1.00 48.30  ? 316 THR B OG1 1 
ATOM   6560 C CG2 . THR D 4 316 ? 160.496 193.193 162.381 1.00 48.30  ? 316 THR B CG2 1 
ATOM   6561 N N   . LYS D 4 317 ? 157.171 193.840 161.948 1.00 37.48  ? 317 LYS B N   1 
ATOM   6562 C CA  . LYS D 4 317 ? 156.127 193.899 162.958 1.00 37.48  ? 317 LYS B CA  1 
ATOM   6563 C C   . LYS D 4 317 ? 154.862 194.472 162.339 1.00 37.48  ? 317 LYS B C   1 
ATOM   6564 O O   . LYS D 4 317 ? 154.916 195.504 161.663 1.00 37.48  ? 317 LYS B O   1 
ATOM   6565 C CB  . LYS D 4 317 ? 156.574 194.757 164.141 1.00 37.48  ? 317 LYS B CB  1 
ATOM   6566 C CG  . LYS D 4 317 ? 155.568 194.820 165.247 1.00 37.48  ? 317 LYS B CG  1 
ATOM   6567 C CD  . LYS D 4 317 ? 155.458 193.479 165.905 1.00 37.48  ? 317 LYS B CD  1 
ATOM   6568 C CE  . LYS D 4 317 ? 156.718 193.174 166.661 1.00 37.48  ? 317 LYS B CE  1 
ATOM   6569 N NZ  . LYS D 4 317 ? 156.882 194.090 167.819 1.00 37.48  ? 317 LYS B NZ  1 
ATOM   6570 N N   . GLU D 4 318 ? 153.731 193.800 162.560 1.00 25.41  ? 318 GLU B N   1 
ATOM   6571 C CA  . GLU D 4 318 ? 152.436 194.291 162.104 1.00 25.41  ? 318 GLU B CA  1 
ATOM   6572 C C   . GLU D 4 318 ? 151.456 194.257 163.264 1.00 25.41  ? 318 GLU B C   1 
ATOM   6573 O O   . GLU D 4 318 ? 151.325 193.233 163.939 1.00 25.41  ? 318 GLU B O   1 
ATOM   6574 C CB  . GLU D 4 318 ? 151.907 193.473 160.926 1.00 25.41  ? 318 GLU B CB  1 
ATOM   6575 C CG  . GLU D 4 318 ? 150.556 193.955 160.414 1.00 25.41  ? 318 GLU B CG  1 
ATOM   6576 C CD  . GLU D 4 318 ? 150.659 195.235 159.602 1.00 25.41  ? 318 GLU B CD  1 
ATOM   6577 O OE1 . GLU D 4 318 ? 151.735 195.489 159.020 1.00 25.41  ? 318 GLU B OE1 1 
ATOM   6578 O OE2 . GLU D 4 318 ? 149.665 195.990 159.552 1.00 25.41  ? 318 GLU B OE2 1 
ATOM   6579 N N   . ILE D 4 319 ? 150.763 195.372 163.480 1.00 25.96  ? 319 ILE B N   1 
ATOM   6580 C CA  . ILE D 4 319 ? 149.868 195.554 164.613 1.00 25.96  ? 319 ILE B CA  1 
ATOM   6581 C C   . ILE D 4 319 ? 148.430 195.501 164.126 1.00 25.96  ? 319 ILE B C   1 
ATOM   6582 O O   . ILE D 4 319 ? 147.986 196.377 163.376 1.00 25.96  ? 319 ILE B O   1 
ATOM   6583 C CB  . ILE D 4 319 ? 150.155 196.883 165.328 1.00 25.96  ? 319 ILE B CB  1 
ATOM   6584 C CG1 . ILE D 4 319 ? 151.556 196.854 165.935 1.00 25.96  ? 319 ILE B CG1 1 
ATOM   6585 C CG2 . ILE D 4 319 ? 149.090 197.181 166.365 1.00 25.96  ? 319 ILE B CG2 1 
ATOM   6586 C CD1 . ILE D 4 319 ? 151.934 198.123 166.637 1.00 25.96  ? 319 ILE B CD1 1 
ATOM   6587 N N   . TYR D 4 320 ? 147.698 194.488 164.564 1.00 27.28  ? 320 TYR B N   1 
ATOM   6588 C CA  . TYR D 4 320 ? 146.304 194.311 164.193 1.00 27.28  ? 320 TYR B CA  1 
ATOM   6589 C C   . TYR D 4 320 ? 145.421 195.043 165.190 1.00 27.28  ? 320 TYR B C   1 
ATOM   6590 O O   . TYR D 4 320 ? 145.639 194.939 166.398 1.00 27.28  ? 320 TYR B O   1 
ATOM   6591 C CB  . TYR D 4 320 ? 145.926 192.834 164.176 1.00 27.28  ? 320 TYR B CB  1 
ATOM   6592 C CG  . TYR D 4 320 ? 146.526 192.018 163.063 1.00 27.28  ? 320 TYR B CG  1 
ATOM   6593 C CD1 . TYR D 4 320 ? 147.246 192.604 162.036 1.00 27.28  ? 320 TYR B CD1 1 
ATOM   6594 C CD2 . TYR D 4 320 ? 146.315 190.657 163.011 1.00 27.28  ? 320 TYR B CD2 1 
ATOM   6595 C CE1 . TYR D 4 320 ? 147.773 191.835 161.018 1.00 27.28  ? 320 TYR B CE1 1 
ATOM   6596 C CE2 . TYR D 4 320 ? 146.827 189.895 162.001 1.00 27.28  ? 320 TYR B CE2 1 
ATOM   6597 C CZ  . TYR D 4 320 ? 147.548 190.481 161.009 1.00 27.28  ? 320 TYR B CZ  1 
ATOM   6598 O OH  . TYR D 4 320 ? 148.036 189.686 160.006 1.00 27.28  ? 320 TYR B OH  1 
ATOM   6599 N N   . THR D 4 321 ? 144.424 195.769 164.693 1.00 31.45  ? 321 THR B N   1 
ATOM   6600 C CA  . THR D 4 321 ? 143.500 196.504 165.548 1.00 31.45  ? 321 THR B CA  1 
ATOM   6601 C C   . THR D 4 321 ? 142.065 196.148 165.197 1.00 31.45  ? 321 THR B C   1 
ATOM   6602 O O   . THR D 4 321 ? 141.717 196.042 164.018 1.00 31.45  ? 321 THR B O   1 
ATOM   6603 C CB  . THR D 4 321 ? 143.706 198.011 165.417 1.00 31.45  ? 321 THR B CB  1 
ATOM   6604 O OG1 . THR D 4 321 ? 145.107 198.298 165.368 1.00 31.45  ? 321 THR B OG1 1 
ATOM   6605 C CG2 . THR D 4 321 ? 143.105 198.712 166.614 1.00 31.45  ? 321 THR B CG2 1 
ATOM   6606 N N   . HIS D 4 322 ? 141.235 195.975 166.214 1.00 39.50  ? 322 HIS B N   1 
ATOM   6607 C CA  . HIS D 4 322 ? 139.826 195.675 166.025 1.00 39.50  ? 322 HIS B CA  1 
ATOM   6608 C C   . HIS D 4 322 ? 138.988 196.591 166.902 1.00 39.50  ? 322 HIS B C   1 
ATOM   6609 O O   . HIS D 4 322 ? 139.331 196.842 168.060 1.00 39.50  ? 322 HIS B O   1 
ATOM   6610 C CB  . HIS D 4 322 ? 139.526 194.213 166.353 1.00 39.50  ? 322 HIS B CB  1 
ATOM   6611 C CG  . HIS D 4 322 ? 138.152 193.772 165.956 1.00 39.50  ? 322 HIS B CG  1 
ATOM   6612 N ND1 . HIS D 4 322 ? 137.254 193.239 166.857 1.00 39.50  ? 322 HIS B ND1 1 
ATOM   6613 C CD2 . HIS D 4 322 ? 137.519 193.786 164.759 1.00 39.50  ? 322 HIS B CD2 1 
ATOM   6614 C CE1 . HIS D 4 322 ? 136.130 192.941 166.231 1.00 39.50  ? 322 HIS B CE1 1 
ATOM   6615 N NE2 . HIS D 4 322 ? 136.264 193.263 164.957 1.00 39.50  ? 322 HIS B NE2 1 
ATOM   6616 N N   . PHE D 4 323 ? 137.890 197.088 166.343 1.00 53.68  ? 323 PHE B N   1 
ATOM   6617 C CA  . PHE D 4 323 ? 136.945 197.916 167.079 1.00 53.68  ? 323 PHE B CA  1 
ATOM   6618 C C   . PHE D 4 323 ? 135.846 197.026 167.640 1.00 53.68  ? 323 PHE B C   1 
ATOM   6619 O O   . PHE D 4 323 ? 135.209 196.275 166.893 1.00 53.68  ? 323 PHE B O   1 
ATOM   6620 C CB  . PHE D 4 323 ? 136.351 198.994 166.176 1.00 53.68  ? 323 PHE B CB  1 
ATOM   6621 C CG  . PHE D 4 323 ? 137.289 200.123 165.881 1.00 53.68  ? 323 PHE B CG  1 
ATOM   6622 C CD1 . PHE D 4 323 ? 138.397 200.351 166.677 1.00 53.68  ? 323 PHE B CD1 1 
ATOM   6623 C CD2 . PHE D 4 323 ? 137.062 200.958 164.801 1.00 53.68  ? 323 PHE B CD2 1 
ATOM   6624 C CE1 . PHE D 4 323 ? 139.259 201.392 166.403 1.00 53.68  ? 323 PHE B CE1 1 
ATOM   6625 C CE2 . PHE D 4 323 ? 137.923 202.002 164.523 1.00 53.68  ? 323 PHE B CE2 1 
ATOM   6626 C CZ  . PHE D 4 323 ? 139.023 202.219 165.327 1.00 53.68  ? 323 PHE B CZ  1 
ATOM   6627 N N   . THR D 4 324 ? 135.619 197.110 168.947 1.00 62.72  ? 324 THR B N   1 
ATOM   6628 C CA  . THR D 4 324 ? 134.627 196.259 169.582 1.00 62.72  ? 324 THR B CA  1 
ATOM   6629 C C   . THR D 4 324 ? 134.027 196.985 170.775 1.00 62.72  ? 324 THR B C   1 
ATOM   6630 O O   . THR D 4 324 ? 134.544 198.006 171.232 1.00 62.72  ? 324 THR B O   1 
ATOM   6631 C CB  . THR D 4 324 ? 135.230 194.920 170.022 1.00 62.72  ? 324 THR B CB  1 
ATOM   6632 O OG1 . THR D 4 324 ? 134.241 194.156 170.724 1.00 62.72  ? 324 THR B OG1 1 
ATOM   6633 C CG2 . THR D 4 324 ? 136.427 195.148 170.928 1.00 62.72  ? 324 THR B CG2 1 
ATOM   6634 N N   . CYS D 4 325 ? 132.913 196.452 171.260 1.00 71.27  ? 325 CYS B N   1 
ATOM   6635 C CA  . CYS D 4 325 ? 132.230 196.956 172.440 1.00 71.27  ? 325 CYS B CA  1 
ATOM   6636 C C   . CYS D 4 325 ? 132.204 195.881 173.520 1.00 71.27  ? 325 CYS B C   1 
ATOM   6637 O O   . CYS D 4 325 ? 132.712 194.771 173.342 1.00 71.27  ? 325 CYS B O   1 
ATOM   6638 C CB  . CYS D 4 325 ? 130.806 197.404 172.096 1.00 71.27  ? 325 CYS B CB  1 
ATOM   6639 S SG  . CYS D 4 325 ? 130.721 198.840 171.006 1.00 71.27  ? 325 CYS B SG  1 
ATOM   6640 N N   . ALA D 4 326 ? 131.600 196.231 174.659 1.00 73.19  ? 326 ALA B N   1 
ATOM   6641 C CA  . ALA D 4 326 ? 131.458 195.276 175.751 1.00 73.19  ? 326 ALA B CA  1 
ATOM   6642 C C   . ALA D 4 326 ? 130.469 194.167 175.424 1.00 73.19  ? 326 ALA B C   1 
ATOM   6643 O O   . ALA D 4 326 ? 130.575 193.073 175.988 1.00 73.19  ? 326 ALA B O   1 
ATOM   6644 C CB  . ALA D 4 326 ? 131.027 195.996 177.030 1.00 73.19  ? 326 ALA B CB  1 
ATOM   6645 N N   . THR D 4 327 ? 129.516 194.421 174.532 1.00 69.73  ? 327 THR B N   1 
ATOM   6646 C CA  . THR D 4 327 ? 128.530 193.438 174.107 1.00 69.73  ? 327 THR B CA  1 
ATOM   6647 C C   . THR D 4 327 ? 128.615 193.205 172.604 1.00 69.73  ? 327 THR B C   1 
ATOM   6648 O O   . THR D 4 327 ? 127.601 193.137 171.906 1.00 69.73  ? 327 THR B O   1 
ATOM   6649 C CB  . THR D 4 327 ? 127.120 193.871 174.502 1.00 69.73  ? 327 THR B CB  1 
ATOM   6650 O OG1 . THR D 4 327 ? 126.904 195.229 174.097 1.00 69.73  ? 327 THR B OG1 1 
ATOM   6651 C CG2 . THR D 4 327 ? 126.933 193.762 176.008 1.00 69.73  ? 327 THR B CG2 1 
ATOM   6652 N N   . ASP D 4 328 ? 129.835 193.083 172.088 1.00 68.07  ? 328 ASP B N   1 
ATOM   6653 C CA  . ASP D 4 328 ? 130.076 192.902 170.664 1.00 68.07  ? 328 ASP B CA  1 
ATOM   6654 C C   . ASP D 4 328 ? 130.753 191.564 170.413 1.00 68.07  ? 328 ASP B C   1 
ATOM   6655 O O   . ASP D 4 328 ? 131.662 191.167 171.148 1.00 68.07  ? 328 ASP B O   1 
ATOM   6656 C CB  . ASP D 4 328 ? 130.940 194.031 170.100 1.00 68.07  ? 328 ASP B CB  1 
ATOM   6657 C CG  . ASP D 4 328 ? 130.814 194.167 168.597 1.00 68.07  ? 328 ASP B CG  1 
ATOM   6658 O OD1 . ASP D 4 328 ? 129.982 193.451 168.000 1.00 68.07  ? 328 ASP B OD1 1 
ATOM   6659 O OD2 . ASP D 4 328 ? 131.549 194.989 168.010 1.00 68.07  ? 328 ASP B OD2 1 
ATOM   6660 N N   . THR D 4 329 ? 130.306 190.879 169.367 1.00 67.26  ? 329 THR B N   1 
ATOM   6661 C CA  . THR D 4 329 ? 130.853 189.590 168.979 1.00 67.26  ? 329 THR B CA  1 
ATOM   6662 C C   . THR D 4 329 ? 131.982 189.792 167.969 1.00 67.26  ? 329 THR B C   1 
ATOM   6663 O O   . THR D 4 329 ? 132.501 190.899 167.802 1.00 67.26  ? 329 THR B O   1 
ATOM   6664 C CB  . THR D 4 329 ? 129.751 188.695 168.418 1.00 67.26  ? 329 THR B CB  1 
ATOM   6665 O OG1 . THR D 4 329 ? 130.322 187.467 167.951 1.00 67.26  ? 329 THR B OG1 1 
ATOM   6666 C CG2 . THR D 4 329 ? 129.038 189.390 167.264 1.00 67.26  ? 329 THR B CG2 1 
ATOM   6667 N N   . LYS D 4 330 ? 132.386 188.695 167.317 1.00 58.86  ? 330 LYS B N   1 
ATOM   6668 C CA  . LYS D 4 330 ? 133.338 188.696 166.201 1.00 58.86  ? 330 LYS B CA  1 
ATOM   6669 C C   . LYS D 4 330 ? 134.716 189.212 166.614 1.00 58.86  ? 330 LYS B C   1 
ATOM   6670 O O   . LYS D 4 330 ? 135.430 189.831 165.824 1.00 58.86  ? 330 LYS B O   1 
ATOM   6671 C CB  . LYS D 4 330 ? 132.798 189.484 165.003 1.00 58.86  ? 330 LYS B CB  1 
ATOM   6672 N N   . ASN D 4 331 ? 135.091 188.960 167.866 1.00 56.33  ? 331 ASN B N   1 
ATOM   6673 C CA  . ASN D 4 331 ? 136.478 189.088 168.296 1.00 56.33  ? 331 ASN B CA  1 
ATOM   6674 C C   . ASN D 4 331 ? 137.256 187.800 168.088 1.00 56.33  ? 331 ASN B C   1 
ATOM   6675 O O   . ASN D 4 331 ? 138.466 187.835 167.828 1.00 56.33  ? 331 ASN B O   1 
ATOM   6676 C CB  . ASN D 4 331 ? 136.547 189.491 169.772 1.00 56.33  ? 331 ASN B CB  1 
ATOM   6677 C CG  . ASN D 4 331 ? 136.036 190.894 170.018 1.00 56.33  ? 331 ASN B CG  1 
ATOM   6678 O OD1 . ASN D 4 331 ? 135.015 191.091 170.677 1.00 56.33  ? 331 ASN B OD1 1 
ATOM   6679 N ND2 . ASN D 4 331 ? 136.755 191.881 169.500 1.00 56.33  ? 331 ASN B ND2 1 
ATOM   6680 N N   . VAL D 4 332 ? 136.565 186.661 168.185 1.00 55.87  ? 332 VAL B N   1 
ATOM   6681 C CA  . VAL D 4 332 ? 137.190 185.373 167.919 1.00 55.87  ? 332 VAL B CA  1 
ATOM   6682 C C   . VAL D 4 332 ? 137.596 185.256 166.455 1.00 55.87  ? 332 VAL B C   1 
ATOM   6683 O O   . VAL D 4 332 ? 138.638 184.672 166.145 1.00 55.87  ? 332 VAL B O   1 
ATOM   6684 C CB  . VAL D 4 332 ? 136.262 184.224 168.366 1.00 55.87  ? 332 VAL B CB  1 
ATOM   6685 C CG1 . VAL D 4 332 ? 136.172 184.188 169.882 1.00 55.87  ? 332 VAL B CG1 1 
ATOM   6686 C CG2 . VAL D 4 332 ? 134.868 184.387 167.777 1.00 55.87  ? 332 VAL B CG2 1 
ATOM   6687 N N   . GLN D 4 333 ? 136.806 185.825 165.537 1.00 50.16  ? 333 GLN B N   1 
ATOM   6688 C CA  . GLN D 4 333 ? 137.202 185.860 164.130 1.00 50.16  ? 333 GLN B CA  1 
ATOM   6689 C C   . GLN D 4 333 ? 138.458 186.689 163.914 1.00 50.16  ? 333 GLN B C   1 
ATOM   6690 O O   . GLN D 4 333 ? 139.349 186.283 163.157 1.00 50.16  ? 333 GLN B O   1 
ATOM   6691 C CB  . GLN D 4 333 ? 136.062 186.396 163.265 1.00 50.16  ? 333 GLN B CB  1 
ATOM   6692 C CG  . GLN D 4 333 ? 136.352 186.337 161.767 1.00 50.16  ? 333 GLN B CG  1 
ATOM   6693 C CD  . GLN D 4 333 ? 136.667 184.942 161.267 1.00 50.16  ? 333 GLN B CD  1 
ATOM   6694 O OE1 . GLN D 4 333 ? 136.016 183.970 161.645 1.00 50.16  ? 333 GLN B OE1 1 
ATOM   6695 N NE2 . GLN D 4 333 ? 137.679 184.838 160.414 1.00 50.16  ? 333 GLN B NE2 1 
ATOM   6696 N N   . PHE D 4 334 ? 138.547 187.849 164.565 1.00 39.15  ? 334 PHE B N   1 
ATOM   6697 C CA  . PHE D 4 334 ? 139.731 188.686 164.417 1.00 39.15  ? 334 PHE B CA  1 
ATOM   6698 C C   . PHE D 4 334 ? 140.970 187.997 164.970 1.00 39.15  ? 334 PHE B C   1 
ATOM   6699 O O   . PHE D 4 334 ? 142.029 188.002 164.327 1.00 39.15  ? 334 PHE B O   1 
ATOM   6700 C CB  . PHE D 4 334 ? 139.518 190.026 165.110 1.00 39.15  ? 334 PHE B CB  1 
ATOM   6701 C CG  . PHE D 4 334 ? 140.516 191.068 164.716 1.00 39.15  ? 334 PHE B CG  1 
ATOM   6702 C CD1 . PHE D 4 334 ? 140.376 191.770 163.534 1.00 39.15  ? 334 PHE B CD1 1 
ATOM   6703 C CD2 . PHE D 4 334 ? 141.600 191.342 165.524 1.00 39.15  ? 334 PHE B CD2 1 
ATOM   6704 C CE1 . PHE D 4 334 ? 141.298 192.731 163.175 1.00 39.15  ? 334 PHE B CE1 1 
ATOM   6705 C CE2 . PHE D 4 334 ? 142.519 192.304 165.168 1.00 39.15  ? 334 PHE B CE2 1 
ATOM   6706 C CZ  . PHE D 4 334 ? 142.371 192.991 163.996 1.00 39.15  ? 334 PHE B CZ  1 
ATOM   6707 N N   . VAL D 4 335 ? 140.855 187.371 166.144 1.00 48.15  ? 335 VAL B N   1 
ATOM   6708 C CA  . VAL D 4 335 ? 142.033 186.728 166.717 1.00 48.15  ? 335 VAL B CA  1 
ATOM   6709 C C   . VAL D 4 335 ? 142.384 185.451 165.949 1.00 48.15  ? 335 VAL B C   1 
ATOM   6710 O O   . VAL D 4 335 ? 143.564 185.099 165.834 1.00 48.15  ? 335 VAL B O   1 
ATOM   6711 C CB  . VAL D 4 335 ? 141.837 186.492 168.231 1.00 48.15  ? 335 VAL B CB  1 
ATOM   6712 C CG1 . VAL D 4 335 ? 140.808 185.418 168.518 1.00 48.15  ? 335 VAL B CG1 1 
ATOM   6713 C CG2 . VAL D 4 335 ? 143.159 186.174 168.898 1.00 48.15  ? 335 VAL B CG2 1 
ATOM   6714 N N   . PHE D 4 336 ? 141.387 184.764 165.374 1.00 48.51  ? 336 PHE B N   1 
ATOM   6715 C CA  . PHE D 4 336 ? 141.664 183.611 164.524 1.00 48.51  ? 336 PHE B CA  1 
ATOM   6716 C C   . PHE D 4 336 ? 142.406 184.016 163.263 1.00 48.51  ? 336 PHE B C   1 
ATOM   6717 O O   . PHE D 4 336 ? 143.371 183.351 162.869 1.00 48.51  ? 336 PHE B O   1 
ATOM   6718 C CB  . PHE D 4 336 ? 140.363 182.902 164.158 1.00 48.51  ? 336 PHE B CB  1 
ATOM   6719 C CG  . PHE D 4 336 ? 140.566 181.642 163.370 1.00 48.51  ? 336 PHE B CG  1 
ATOM   6720 C CD1 . PHE D 4 336 ? 141.142 180.529 163.951 1.00 48.51  ? 336 PHE B CD1 1 
ATOM   6721 C CD2 . PHE D 4 336 ? 140.197 181.583 162.037 1.00 48.51  ? 336 PHE B CD2 1 
ATOM   6722 C CE1 . PHE D 4 336 ? 141.333 179.374 163.223 1.00 48.51  ? 336 PHE B CE1 1 
ATOM   6723 C CE2 . PHE D 4 336 ? 140.387 180.433 161.304 1.00 48.51  ? 336 PHE B CE2 1 
ATOM   6724 C CZ  . PHE D 4 336 ? 140.957 179.326 161.898 1.00 48.51  ? 336 PHE B CZ  1 
ATOM   6725 N N   . ASP D 4 337 ? 141.965 185.100 162.617 1.00 47.23  ? 337 ASP B N   1 
ATOM   6726 C CA  . ASP D 4 337 ? 142.661 185.599 161.436 1.00 47.23  ? 337 ASP B CA  1 
ATOM   6727 C C   . ASP D 4 337 ? 144.077 186.021 161.787 1.00 47.23  ? 337 ASP B C   1 
ATOM   6728 O O   . ASP D 4 337 ? 145.021 185.768 161.024 1.00 47.23  ? 337 ASP B O   1 
ATOM   6729 C CB  . ASP D 4 337 ? 141.887 186.762 160.821 1.00 47.23  ? 337 ASP B CB  1 
ATOM   6730 C CG  . ASP D 4 337 ? 140.560 186.329 160.237 1.00 47.23  ? 337 ASP B CG  1 
ATOM   6731 O OD1 . ASP D 4 337 ? 140.437 185.148 159.855 1.00 47.23  ? 337 ASP B OD1 1 
ATOM   6732 O OD2 . ASP D 4 337 ? 139.637 187.165 160.167 1.00 47.23  ? 337 ASP B OD2 1 
ATOM   6733 N N   . ALA D 4 338 ? 144.246 186.612 162.970 1.00 44.06  ? 338 ALA B N   1 
ATOM   6734 C CA  . ALA D 4 338 ? 145.565 187.013 163.439 1.00 44.06  ? 338 ALA B CA  1 
ATOM   6735 C C   . ALA D 4 338 ? 146.498 185.819 163.601 1.00 44.06  ? 338 ALA B C   1 
ATOM   6736 O O   . ALA D 4 338 ? 147.621 185.811 163.075 1.00 44.06  ? 338 ALA B O   1 
ATOM   6737 C CB  . ALA D 4 338 ? 145.418 187.758 164.761 1.00 44.06  ? 338 ALA B CB  1 
ATOM   6738 N N   . VAL D 4 339 ? 146.043 184.798 164.327 1.00 45.04  ? 339 VAL B N   1 
ATOM   6739 C CA  . VAL D 4 339 ? 146.892 183.649 164.612 1.00 45.04  ? 339 VAL B CA  1 
ATOM   6740 C C   . VAL D 4 339 ? 147.173 182.861 163.336 1.00 45.04  ? 339 VAL B C   1 
ATOM   6741 O O   . VAL D 4 339 ? 148.286 182.355 163.140 1.00 45.04  ? 339 VAL B O   1 
ATOM   6742 C CB  . VAL D 4 339 ? 146.248 182.788 165.715 1.00 45.04  ? 339 VAL B CB  1 
ATOM   6743 C CG1 . VAL D 4 339 ? 147.011 181.502 165.918 1.00 45.04  ? 339 VAL B CG1 1 
ATOM   6744 C CG2 . VAL D 4 339 ? 146.204 183.569 167.014 1.00 45.04  ? 339 VAL B CG2 1 
ATOM   6745 N N   . THR D 4 340 ? 146.194 182.783 162.424 1.00 47.11  ? 340 THR B N   1 
ATOM   6746 C CA  . THR D 4 340 ? 146.438 182.100 161.158 1.00 47.11  ? 340 THR B CA  1 
ATOM   6747 C C   . THR D 4 340 ? 147.468 182.840 160.316 1.00 47.11  ? 340 THR B C   1 
ATOM   6748 O O   . THR D 4 340 ? 148.312 182.207 159.675 1.00 47.11  ? 340 THR B O   1 
ATOM   6749 C CB  . THR D 4 340 ? 145.147 181.923 160.365 1.00 47.11  ? 340 THR B CB  1 
ATOM   6750 O OG1 . THR D 4 340 ? 144.406 183.143 160.376 1.00 47.11  ? 340 THR B OG1 1 
ATOM   6751 C CG2 . THR D 4 340 ? 144.305 180.812 160.968 1.00 47.11  ? 340 THR B CG2 1 
ATOM   6752 N N   . ASP D 4 341 ? 147.434 184.177 160.310 1.00 43.03  ? 341 ASP B N   1 
ATOM   6753 C CA  . ASP D 4 341 ? 148.448 184.910 159.556 1.00 43.03  ? 341 ASP B CA  1 
ATOM   6754 C C   . ASP D 4 341 ? 149.837 184.731 160.165 1.00 43.03  ? 341 ASP B C   1 
ATOM   6755 O O   . ASP D 4 341 ? 150.829 184.576 159.434 1.00 43.03  ? 341 ASP B O   1 
ATOM   6756 C CB  . ASP D 4 341 ? 148.082 186.387 159.477 1.00 43.03  ? 341 ASP B CB  1 
ATOM   6757 C CG  . ASP D 4 341 ? 148.759 187.091 158.322 1.00 43.03  ? 341 ASP B CG  1 
ATOM   6758 O OD1 . ASP D 4 341 ? 149.557 186.445 157.615 1.00 43.03  ? 341 ASP B OD1 1 
ATOM   6759 O OD2 . ASP D 4 341 ? 148.488 188.291 158.116 1.00 43.03  ? 341 ASP B OD2 1 
ATOM   6760 N N   . VAL D 4 342 ? 149.927 184.725 161.499 1.00 47.11  ? 342 VAL B N   1 
ATOM   6761 C CA  . VAL D 4 342 ? 151.237 184.566 162.131 1.00 47.11  ? 342 VAL B CA  1 
ATOM   6762 C C   . VAL D 4 342 ? 151.786 183.160 161.885 1.00 47.11  ? 342 VAL B C   1 
ATOM   6763 O O   . VAL D 4 342 ? 152.986 182.981 161.643 1.00 47.11  ? 342 VAL B O   1 
ATOM   6764 C CB  . VAL D 4 342 ? 151.170 184.904 163.632 1.00 47.11  ? 342 VAL B CB  1 
ATOM   6765 C CG1 . VAL D 4 342 ? 152.536 184.745 164.271 1.00 47.11  ? 342 VAL B CG1 1 
ATOM   6766 C CG2 . VAL D 4 342 ? 150.690 186.323 163.835 1.00 47.11  ? 342 VAL B CG2 1 
ATOM   6767 N N   . ILE D 4 343 ? 150.923 182.142 161.895 1.00 48.11  ? 343 ILE B N   1 
ATOM   6768 C CA  . ILE D 4 343 ? 151.435 180.807 161.604 1.00 48.11  ? 343 ILE B CA  1 
ATOM   6769 C C   . ILE D 4 343 ? 151.698 180.597 160.118 1.00 48.11  ? 343 ILE B C   1 
ATOM   6770 O O   . ILE D 4 343 ? 152.523 179.747 159.770 1.00 48.11  ? 343 ILE B O   1 
ATOM   6771 C CB  . ILE D 4 343 ? 150.522 179.701 162.158 1.00 48.11  ? 343 ILE B CB  1 
ATOM   6772 C CG1 . ILE D 4 343 ? 149.175 179.670 161.450 1.00 48.11  ? 343 ILE B CG1 1 
ATOM   6773 C CG2 . ILE D 4 343 ? 150.338 179.874 163.646 1.00 48.11  ? 343 ILE B CG2 1 
ATOM   6774 C CD1 . ILE D 4 343 ? 148.243 178.602 161.973 1.00 48.11  ? 343 ILE B CD1 1 
ATOM   6775 N N   . ILE D 4 344 ? 151.065 181.362 159.224 1.00 49.21  ? 344 ILE B N   1 
ATOM   6776 C CA  . ILE D 4 344 ? 151.524 181.361 157.834 1.00 49.21  ? 344 ILE B CA  1 
ATOM   6777 C C   . ILE D 4 344 ? 152.931 181.933 157.742 1.00 49.21  ? 344 ILE B C   1 
ATOM   6778 O O   . ILE D 4 344 ? 153.786 181.399 157.018 1.00 49.21  ? 344 ILE B O   1 
ATOM   6779 C CB  . ILE D 4 344 ? 150.541 182.118 156.919 1.00 49.21  ? 344 ILE B CB  1 
ATOM   6780 C CG1 . ILE D 4 344 ? 149.263 181.315 156.722 1.00 49.21  ? 344 ILE B CG1 1 
ATOM   6781 C CG2 . ILE D 4 344 ? 151.157 182.414 155.574 1.00 49.21  ? 344 ILE B CG2 1 
ATOM   6782 C CD1 . ILE D 4 344 ? 148.164 182.087 156.038 1.00 49.21  ? 344 ILE B CD1 1 
ATOM   6783 N N   . LYS D 4 345 ? 153.201 183.012 158.493 1.00 54.59  ? 345 LYS B N   1 
ATOM   6784 C CA  . LYS D 4 345 ? 154.564 183.544 158.546 1.00 54.59  ? 345 LYS B CA  1 
ATOM   6785 C C   . LYS D 4 345 ? 155.548 182.501 159.076 1.00 54.59  ? 345 LYS B C   1 
ATOM   6786 O O   . LYS D 4 345 ? 156.657 182.345 158.541 1.00 54.59  ? 345 LYS B O   1 
ATOM   6787 C CB  . LYS D 4 345 ? 154.604 184.798 159.402 1.00 54.59  ? 345 LYS B CB  1 
ATOM   6788 C CG  . LYS D 4 345 ? 156.002 185.222 159.856 1.00 54.59  ? 345 LYS B CG  1 
ATOM   6789 C CD  . LYS D 4 345 ? 155.927 186.346 160.884 1.00 54.59  ? 345 LYS B CD  1 
ATOM   6790 C CE  . LYS D 4 345 ? 155.588 185.821 162.274 1.00 54.59  ? 345 LYS B CE  1 
ATOM   6791 N NZ  . LYS D 4 345 ? 154.949 186.862 163.129 1.00 54.59  ? 345 LYS B NZ  1 
ATOM   6792 N N   . ASN D 4 346 ? 155.137 181.752 160.104 1.00 56.88  ? 346 ASN B N   1 
ATOM   6793 C CA  . ASN D 4 346 ? 155.959 180.662 160.632 1.00 56.88  ? 346 ASN B CA  1 
ATOM   6794 C C   . ASN D 4 346 ? 156.215 179.583 159.582 1.00 56.88  ? 346 ASN B C   1 
ATOM   6795 O O   . ASN D 4 346 ? 157.336 179.072 159.469 1.00 56.88  ? 346 ASN B O   1 
ATOM   6796 C CB  . ASN D 4 346 ? 155.284 180.042 161.854 1.00 56.88  ? 346 ASN B CB  1 
ATOM   6797 C CG  . ASN D 4 346 ? 155.502 180.847 163.108 1.00 56.88  ? 346 ASN B CG  1 
ATOM   6798 O OD1 . ASN D 4 346 ? 156.188 181.866 163.090 1.00 56.88  ? 346 ASN B OD1 1 
ATOM   6799 N ND2 . ASN D 4 346 ? 154.915 180.396 164.212 1.00 56.88  ? 346 ASN B ND2 1 
ATOM   6800 N N   . ASN D 4 347 ? 155.184 179.216 158.817 1.00 54.56  ? 347 ASN B N   1 
ATOM   6801 C CA  . ASN D 4 347 ? 155.328 178.159 157.823 1.00 54.56  ? 347 ASN B CA  1 
ATOM   6802 C C   . ASN D 4 347 ? 156.181 178.597 156.639 1.00 54.56  ? 347 ASN B C   1 
ATOM   6803 O O   . ASN D 4 347 ? 156.815 177.756 155.995 1.00 54.56  ? 347 ASN B O   1 
ATOM   6804 C CB  . ASN D 4 347 ? 153.953 177.697 157.350 1.00 54.56  ? 347 ASN B CB  1 
ATOM   6805 C CG  . ASN D 4 347 ? 153.139 177.086 158.464 1.00 54.56  ? 347 ASN B CG  1 
ATOM   6806 O OD1 . ASN D 4 347 ? 153.659 176.819 159.545 1.00 54.56  ? 347 ASN B OD1 1 
ATOM   6807 N ND2 . ASN D 4 347 ? 151.855 176.866 158.214 1.00 54.56  ? 347 ASN B ND2 1 
ATOM   6808 N N   . LEU D 4 348 ? 156.185 179.893 156.315 1.00 60.39  ? 348 LEU B N   1 
ATOM   6809 C CA  . LEU D 4 348 ? 157.178 180.386 155.364 1.00 60.39  ? 348 LEU B CA  1 
ATOM   6810 C C   . LEU D 4 348 ? 158.573 180.389 155.980 1.00 60.39  ? 348 LEU B C   1 
ATOM   6811 O O   . LEU D 4 348 ? 159.562 180.171 155.271 1.00 60.39  ? 348 LEU B O   1 
ATOM   6812 C CB  . LEU D 4 348 ? 156.834 181.793 154.859 1.00 60.39  ? 348 LEU B CB  1 
ATOM   6813 C CG  . LEU D 4 348 ? 155.864 182.090 153.699 1.00 60.39  ? 348 LEU B CG  1 
ATOM   6814 C CD1 . LEU D 4 348 ? 156.363 181.502 152.400 1.00 60.39  ? 348 LEU B CD1 1 
ATOM   6815 C CD2 . LEU D 4 348 ? 154.450 181.661 153.941 1.00 60.39  ? 348 LEU B CD2 1 
ATOM   6816 N N   . LYS D 4 349 ? 158.670 180.630 157.289 1.00 63.66  ? 349 LYS B N   1 
ATOM   6817 C CA  . LYS D 4 349 ? 159.977 180.742 157.931 1.00 63.66  ? 349 LYS B CA  1 
ATOM   6818 C C   . LYS D 4 349 ? 160.687 179.395 158.026 1.00 63.66  ? 349 LYS B C   1 
ATOM   6819 O O   . LYS D 4 349 ? 161.887 179.297 157.741 1.00 63.66  ? 349 LYS B O   1 
ATOM   6820 C CB  . LYS D 4 349 ? 159.821 181.363 159.317 1.00 63.66  ? 349 LYS B CB  1 
ATOM   6821 C CG  . LYS D 4 349 ? 159.855 182.875 159.304 1.00 63.66  ? 349 LYS B CG  1 
ATOM   6822 C CD  . LYS D 4 349 ? 161.230 183.349 158.868 1.00 63.66  ? 349 LYS B CD  1 
ATOM   6823 C CE  . LYS D 4 349 ? 162.298 183.017 159.901 1.00 63.66  ? 349 LYS B CE  1 
ATOM   6824 N NZ  . LYS D 4 349 ? 163.637 183.520 159.481 1.00 63.66  ? 349 LYS B NZ  1 
ATOM   6825 N N   . ASP D 4 350 ? 159.978 178.349 158.457 1.00 65.93  ? 350 ASP B N   1 
ATOM   6826 C CA  . ASP D 4 350 ? 160.649 177.062 158.624 1.00 65.93  ? 350 ASP B CA  1 
ATOM   6827 C C   . ASP D 4 350 ? 160.902 176.371 157.289 1.00 65.93  ? 350 ASP B C   1 
ATOM   6828 O O   . ASP D 4 350 ? 161.879 175.626 157.160 1.00 65.93  ? 350 ASP B O   1 
ATOM   6829 C CB  . ASP D 4 350 ? 159.858 176.147 159.568 1.00 65.93  ? 350 ASP B CB  1 
ATOM   6830 C CG  . ASP D 4 350 ? 158.581 175.611 158.948 1.00 65.93  ? 350 ASP B CG  1 
ATOM   6831 O OD1 . ASP D 4 350 ? 158.001 176.296 158.087 1.00 65.93  ? 350 ASP B OD1 1 
ATOM   6832 O OD2 . ASP D 4 350 ? 158.157 174.497 159.319 1.00 65.93  ? 350 ASP B OD2 1 
ATOM   6833 N N   . CYS D 4 351 ? 160.044 176.605 156.291 1.00 64.64  ? 351 CYS B N   1 
ATOM   6834 C CA  . CYS D 4 351 ? 160.274 176.064 154.957 1.00 64.64  ? 351 CYS B CA  1 
ATOM   6835 C C   . CYS D 4 351 ? 161.399 176.782 154.227 1.00 64.64  ? 351 CYS B C   1 
ATOM   6836 O O   . CYS D 4 351 ? 161.928 176.238 153.252 1.00 64.64  ? 351 CYS B O   1 
ATOM   6837 C CB  . CYS D 4 351 ? 158.988 176.133 154.130 1.00 64.64  ? 351 CYS B CB  1 
ATOM   6838 S SG  . CYS D 4 351 ? 157.723 174.940 154.627 1.00 64.64  ? 351 CYS B SG  1 
ATOM   6839 N N   . GLY D 4 352 ? 161.774 177.979 154.673 1.00 66.12  ? 352 GLY B N   1 
ATOM   6840 C CA  . GLY D 4 352 ? 162.927 178.666 154.131 1.00 66.12  ? 352 GLY B CA  1 
ATOM   6841 C C   . GLY D 4 352 ? 162.646 179.691 153.057 1.00 66.12  ? 352 GLY B C   1 
ATOM   6842 O O   . GLY D 4 352 ? 163.429 179.808 152.110 1.00 66.12  ? 352 GLY B O   1 
ATOM   6843 N N   . LEU D 4 353 ? 161.555 180.446 153.168 1.00 67.33  ? 353 LEU B N   1 
ATOM   6844 C CA  . LEU D 4 353 ? 161.218 181.451 152.168 1.00 67.33  ? 353 LEU B CA  1 
ATOM   6845 C C   . LEU D 4 353 ? 161.126 182.860 152.736 1.00 67.33  ? 353 LEU B C   1 
ATOM   6846 O O   . LEU D 4 353 ? 161.614 183.807 152.111 1.00 67.33  ? 353 LEU B O   1 
ATOM   6847 C CB  . LEU D 4 353 ? 159.906 181.076 151.464 1.00 67.33  ? 353 LEU B CB  1 
ATOM   6848 C CG  . LEU D 4 353 ? 159.808 179.640 150.947 1.00 67.33  ? 353 LEU B CG  1 
ATOM   6849 C CD1 . LEU D 4 353 ? 158.468 179.385 150.282 1.00 67.33  ? 353 LEU B CD1 1 
ATOM   6850 C CD2 . LEU D 4 353 ? 160.937 179.353 149.983 1.00 67.33  ? 353 LEU B CD2 1 
ATOM   6851 N N   . PHE D 4 354 ? 160.498 183.034 153.896 1.00 67.93  ? 354 PHE B N   1 
ATOM   6852 C CA  . PHE D 4 354 ? 160.394 184.356 154.514 1.00 67.93  ? 354 PHE B CA  1 
ATOM   6853 C C   . PHE D 4 354 ? 161.688 184.707 155.235 1.00 67.93  ? 354 PHE B C   1 
ATOM   6854 O O   . PHE D 4 354 ? 162.208 185.812 155.089 1.00 67.93  ? 354 PHE B O   1 
ATOM   6855 C CB  . PHE D 4 354 ? 159.212 184.408 155.487 1.00 67.93  ? 354 PHE B CB  1 
ATOM   6856 C CG  . PHE D 4 354 ? 158.827 185.801 155.921 1.00 67.93  ? 354 PHE B CG  1 
ATOM   6857 C CD1 . PHE D 4 354 ? 158.151 186.650 155.057 1.00 67.93  ? 354 PHE B CD1 1 
ATOM   6858 C CD2 . PHE D 4 354 ? 159.102 186.243 157.207 1.00 67.93  ? 354 PHE B CD2 1 
ATOM   6859 C CE1 . PHE D 4 354 ? 157.784 187.926 155.459 1.00 67.93  ? 354 PHE B CE1 1 
ATOM   6860 C CE2 . PHE D 4 354 ? 158.735 187.517 157.615 1.00 67.93  ? 354 PHE B CE2 1 
ATOM   6861 C CZ  . PHE D 4 354 ? 158.075 188.358 156.739 1.00 67.93  ? 354 PHE B CZ  1 
HETATM 6862 C C1  . JDC E 5 .   ? 165.252 157.409 129.586 1.00 66.84  ? 401 JDC A C1  1 
HETATM 6863 N N2  . JDC E 5 .   ? 166.487 158.149 129.455 1.00 66.84  ? 401 JDC A N2  1 
HETATM 6864 C C3  . JDC E 5 .   ? 166.536 159.241 130.399 1.00 66.84  ? 401 JDC A C3  1 
HETATM 6865 C C4  . JDC E 5 .   ? 165.437 160.278 130.149 1.00 66.84  ? 401 JDC A C4  1 
HETATM 6866 C C4A . JDC E 5 .   ? 164.110 159.633 129.841 1.00 66.84  ? 401 JDC A C4A 1 
HETATM 6867 C C5  . JDC E 5 .   ? 162.948 160.397 129.824 1.00 66.84  ? 401 JDC A C5  1 
HETATM 6868 C C6  . JDC E 5 .   ? 161.714 159.835 129.552 1.00 66.84  ? 401 JDC A C6  1 
HETATM 6869 C C7  . JDC E 5 .   ? 161.622 158.473 129.286 1.00 66.84  ? 401 JDC A C7  1 
HETATM 6870 O O7  . JDC E 5 .   ? 160.449 157.867 129.012 1.00 66.84  ? 401 JDC A O7  1 
HETATM 6871 C C8  . JDC E 5 .   ? 162.772 157.696 129.300 1.00 66.84  ? 401 JDC A C8  1 
HETATM 6872 C C8A . JDC E 5 .   ? 164.009 158.269 129.578 1.00 66.84  ? 401 JDC A C8A 1 
HETATM 6873 C C1A . JDC E 5 .   ? 167.879 159.940 130.306 1.00 66.84  ? 401 JDC A C1A 1 
HETATM 6874 O O1  . JDC E 5 .   ? 168.462 160.032 129.238 1.00 66.84  ? 401 JDC A O1  1 
HETATM 6875 N N2A . JDC E 5 .   ? 168.344 160.428 131.464 1.00 66.84  ? 401 JDC A N2A 1 
HETATM 6876 C C2A . JDC E 5 .   ? 169.596 161.143 131.598 1.00 66.84  ? 401 JDC A C2A 1 
HETATM 6877 C C3A . JDC E 5 .   ? 169.370 162.488 132.299 1.00 66.84  ? 401 JDC A C3A 1 
HETATM 6878 C C3D . JDC E 5 .   ? 170.692 163.190 132.592 1.00 66.84  ? 401 JDC A C3D 1 
HETATM 6879 C C3B . JDC E 5 .   ? 168.558 162.322 133.578 1.00 66.84  ? 401 JDC A C3B 1 
HETATM 6880 C C4D . JDC E 5 .   ? 170.621 160.289 132.360 1.00 66.84  ? 401 JDC A C4D 1 
HETATM 6881 N N11 . JDC E 5 .   ? 170.983 159.077 131.669 1.00 66.84  ? 401 JDC A N11 1 
HETATM 6882 C C21 . JDC E 5 .   ? 171.685 159.355 130.432 1.00 66.84  ? 401 JDC A C21 1 
HETATM 6883 C C31 . JDC E 5 .   ? 171.928 158.081 129.625 1.00 66.84  ? 401 JDC A C31 1 
HETATM 6884 C C34 . JDC E 5 .   ? 170.601 157.527 129.102 1.00 66.84  ? 401 JDC A C34 1 
HETATM 6885 C C41 . JDC E 5 .   ? 172.754 157.073 130.470 1.00 66.84  ? 401 JDC A C41 1 
HETATM 6886 C C51 . JDC E 5 .   ? 172.033 156.867 131.811 1.00 66.84  ? 401 JDC A C51 1 
HETATM 6887 C C61 . JDC E 5 .   ? 171.739 158.180 132.526 1.00 66.84  ? 401 JDC A C61 1 
HETATM 6888 C C4E . JDC E 5 .   ? 174.158 157.631 130.750 1.00 66.84  ? 401 JDC A C4E 1 
HETATM 6889 C C1C . JDC E 5 .   ? 172.941 155.772 129.695 1.00 66.84  ? 401 JDC A C1C 1 
HETATM 6890 C C2C . JDC E 5 .   ? 173.628 155.800 128.480 1.00 66.84  ? 401 JDC A C2C 1 
HETATM 6891 C C3C . JDC E 5 .   ? 173.821 154.645 127.734 1.00 66.84  ? 401 JDC A C3C 1 
HETATM 6892 O O3C . JDC E 5 .   ? 174.495 154.758 126.568 1.00 66.84  ? 401 JDC A O3C 1 
HETATM 6893 C C4C . JDC E 5 .   ? 173.331 153.427 128.199 1.00 66.84  ? 401 JDC A C4C 1 
HETATM 6894 C C5C . JDC E 5 .   ? 172.650 153.393 129.404 1.00 66.84  ? 401 JDC A C5C 1 
HETATM 6895 C C6C . JDC E 5 .   ? 172.455 154.548 130.150 1.00 66.84  ? 401 JDC A C6C 1 
# 
