data_9D17
# 
_entry.id   9D17 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9D17         pdb_00009d17 10.2210/pdb9d17/pdb 
WWPDB D_1000286432 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-16 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9D17 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-07 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              Samir.Moussa@istx.com 
_pdbx_contact_author.name_first         Samir 
_pdbx_contact_author.name_last          Moussa 
_pdbx_contact_author.name_mi            H 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5348-596X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sawyer, T.K.' 1 0000-0002-3600-210X 
'Wibowo, A.S.' 2 0000-0002-0955-8903 
'Carter, J.'   3 0000-0001-7322-349X 
'Moussa, S.H.' 4 0000-0001-5348-596X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   FR 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Eur.J.Med.Chem. 
_citation.journal_id_ASTM           EJMCA5 
_citation.journal_id_CSD            0493 
_citation.journal_id_ISSN           0223-5234 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            289 
_citation.language                  ? 
_citation.page_first                117238 
_citation.page_last                 117238 
_citation.title                     'Small molecule inhibitors of mannan-binding lectin-associated serine Proteases-2 and-3.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.ejmech.2025.117238 
_citation.pdbx_database_id_PubMed   40010268 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Nakhla, M.C.'    1 ? 
primary 'Comita, J.'      2 ? 
primary 'Shapiro, A.B.'   3 ? 
primary 'Moussa, S.H.'    4 ? 
primary 'Chen, A.'        5 ? 
primary 'Eyermann, C.J.'  6 ? 
primary 
;O'Donnell, J.P.
;
7 ? 
primary 'Miller, A.A.'    8 ? 
primary 'Granger, B.A.'   9 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Mannan-binding lectin serine protease 2 B chain'                       35365.852 1  3.4.21.104 ? ? ? 
2 non-polymer syn '2-(2-amino-1H-1,3-benzimidazol-1-yl)-N-(5-ethylpyridin-2-yl)acetamide' 295.339   1  ?          ? ? ? 
3 non-polymer syn GLYCEROL                                                                92.094    2  ?          ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                                    78.133    3  ?          ? ? ? 
5 water       nat water                                                                   18.015    58 ?          ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;IVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTG
GRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEG
YTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAY
EKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENI
ISDF
;
_entity_poly.pdbx_seq_one_letter_code_can   
;IVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTG
GRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEG
YTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAY
EKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENI
ISDF
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '2-(2-amino-1H-1,3-benzimidazol-1-yl)-N-(5-ethylpyridin-2-yl)acetamide' A1A1X 
3 GLYCEROL                                                                GOL   
4 'DIMETHYL SULFOXIDE'                                                    DMS   
5 water                                                                   HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ILE n 
1 2   VAL n 
1 3   ASP n 
1 4   CYS n 
1 5   GLY n 
1 6   PRO n 
1 7   PRO n 
1 8   ASP n 
1 9   ASP n 
1 10  LEU n 
1 11  PRO n 
1 12  SER n 
1 13  GLY n 
1 14  ARG n 
1 15  VAL n 
1 16  GLU n 
1 17  TYR n 
1 18  ILE n 
1 19  THR n 
1 20  GLY n 
1 21  PRO n 
1 22  GLY n 
1 23  VAL n 
1 24  THR n 
1 25  THR n 
1 26  TYR n 
1 27  LYS n 
1 28  ALA n 
1 29  VAL n 
1 30  ILE n 
1 31  GLN n 
1 32  TYR n 
1 33  SER n 
1 34  CYS n 
1 35  GLU n 
1 36  GLU n 
1 37  THR n 
1 38  PHE n 
1 39  TYR n 
1 40  THR n 
1 41  MET n 
1 42  LYS n 
1 43  VAL n 
1 44  ASN n 
1 45  ASP n 
1 46  GLY n 
1 47  LYS n 
1 48  TYR n 
1 49  VAL n 
1 50  CYS n 
1 51  GLU n 
1 52  ALA n 
1 53  ASP n 
1 54  GLY n 
1 55  PHE n 
1 56  TRP n 
1 57  THR n 
1 58  SER n 
1 59  SER n 
1 60  LYS n 
1 61  GLY n 
1 62  GLU n 
1 63  LYS n 
1 64  SER n 
1 65  LEU n 
1 66  PRO n 
1 67  VAL n 
1 68  CYS n 
1 69  GLU n 
1 70  PRO n 
1 71  VAL n 
1 72  CYS n 
1 73  GLY n 
1 74  LEU n 
1 75  SER n 
1 76  ALA n 
1 77  ARG n 
1 78  THR n 
1 79  THR n 
1 80  GLY n 
1 81  GLY n 
1 82  ARG n 
1 83  ILE n 
1 84  TYR n 
1 85  GLY n 
1 86  GLY n 
1 87  GLN n 
1 88  LYS n 
1 89  ALA n 
1 90  LYS n 
1 91  PRO n 
1 92  GLY n 
1 93  ASP n 
1 94  PHE n 
1 95  PRO n 
1 96  TRP n 
1 97  GLN n 
1 98  VAL n 
1 99  LEU n 
1 100 ILE n 
1 101 LEU n 
1 102 GLY n 
1 103 GLY n 
1 104 THR n 
1 105 THR n 
1 106 ALA n 
1 107 ALA n 
1 108 GLY n 
1 109 ALA n 
1 110 LEU n 
1 111 LEU n 
1 112 TYR n 
1 113 ASP n 
1 114 ASN n 
1 115 TRP n 
1 116 VAL n 
1 117 LEU n 
1 118 THR n 
1 119 ALA n 
1 120 ALA n 
1 121 HIS n 
1 122 ALA n 
1 123 VAL n 
1 124 TYR n 
1 125 GLU n 
1 126 GLN n 
1 127 LYS n 
1 128 HIS n 
1 129 ASP n 
1 130 ALA n 
1 131 SER n 
1 132 ALA n 
1 133 LEU n 
1 134 ASP n 
1 135 ILE n 
1 136 ARG n 
1 137 MET n 
1 138 GLY n 
1 139 THR n 
1 140 LEU n 
1 141 LYS n 
1 142 ARG n 
1 143 LEU n 
1 144 SER n 
1 145 PRO n 
1 146 HIS n 
1 147 TYR n 
1 148 THR n 
1 149 GLN n 
1 150 ALA n 
1 151 TRP n 
1 152 SER n 
1 153 GLU n 
1 154 ALA n 
1 155 VAL n 
1 156 PHE n 
1 157 ILE n 
1 158 HIS n 
1 159 GLU n 
1 160 GLY n 
1 161 TYR n 
1 162 THR n 
1 163 HIS n 
1 164 ASP n 
1 165 ALA n 
1 166 GLY n 
1 167 PHE n 
1 168 ASP n 
1 169 ASN n 
1 170 ASP n 
1 171 ILE n 
1 172 ALA n 
1 173 LEU n 
1 174 ILE n 
1 175 LYS n 
1 176 LEU n 
1 177 ASN n 
1 178 ASN n 
1 179 LYS n 
1 180 VAL n 
1 181 VAL n 
1 182 ILE n 
1 183 ASN n 
1 184 SER n 
1 185 ASN n 
1 186 ILE n 
1 187 THR n 
1 188 PRO n 
1 189 ILE n 
1 190 CYS n 
1 191 LEU n 
1 192 PRO n 
1 193 ARG n 
1 194 LYS n 
1 195 GLU n 
1 196 ALA n 
1 197 GLU n 
1 198 SER n 
1 199 PHE n 
1 200 MET n 
1 201 ARG n 
1 202 THR n 
1 203 ASP n 
1 204 ASP n 
1 205 ILE n 
1 206 GLY n 
1 207 THR n 
1 208 ALA n 
1 209 SER n 
1 210 GLY n 
1 211 TRP n 
1 212 GLY n 
1 213 LEU n 
1 214 THR n 
1 215 GLN n 
1 216 ARG n 
1 217 GLY n 
1 218 PHE n 
1 219 LEU n 
1 220 ALA n 
1 221 ARG n 
1 222 ASN n 
1 223 LEU n 
1 224 MET n 
1 225 TYR n 
1 226 VAL n 
1 227 ASP n 
1 228 ILE n 
1 229 PRO n 
1 230 ILE n 
1 231 VAL n 
1 232 ASP n 
1 233 HIS n 
1 234 GLN n 
1 235 LYS n 
1 236 CYS n 
1 237 THR n 
1 238 ALA n 
1 239 ALA n 
1 240 TYR n 
1 241 GLU n 
1 242 LYS n 
1 243 PRO n 
1 244 PRO n 
1 245 TYR n 
1 246 PRO n 
1 247 ARG n 
1 248 GLY n 
1 249 SER n 
1 250 VAL n 
1 251 THR n 
1 252 ALA n 
1 253 ASN n 
1 254 MET n 
1 255 LEU n 
1 256 CYS n 
1 257 ALA n 
1 258 GLY n 
1 259 LEU n 
1 260 GLU n 
1 261 SER n 
1 262 GLY n 
1 263 GLY n 
1 264 LYS n 
1 265 ASP n 
1 266 SER n 
1 267 CYS n 
1 268 ARG n 
1 269 GLY n 
1 270 ASP n 
1 271 SER n 
1 272 GLY n 
1 273 GLY n 
1 274 ALA n 
1 275 LEU n 
1 276 VAL n 
1 277 PHE n 
1 278 LEU n 
1 279 ASP n 
1 280 SER n 
1 281 GLU n 
1 282 THR n 
1 283 GLU n 
1 284 ARG n 
1 285 TRP n 
1 286 PHE n 
1 287 VAL n 
1 288 GLY n 
1 289 GLY n 
1 290 ILE n 
1 291 VAL n 
1 292 SER n 
1 293 TRP n 
1 294 GLY n 
1 295 SER n 
1 296 MET n 
1 297 ASN n 
1 298 CYS n 
1 299 GLY n 
1 300 GLU n 
1 301 ALA n 
1 302 GLY n 
1 303 GLN n 
1 304 TYR n 
1 305 GLY n 
1 306 VAL n 
1 307 TYR n 
1 308 THR n 
1 309 LYS n 
1 310 VAL n 
1 311 ILE n 
1 312 ASN n 
1 313 TYR n 
1 314 ILE n 
1 315 PRO n 
1 316 TRP n 
1 317 ILE n 
1 318 GLU n 
1 319 ASN n 
1 320 ILE n 
1 321 ILE n 
1 322 SER n 
1 323 ASP n 
1 324 PHE n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   324 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 MASP2 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               'SHuffle(DE3) plysS' 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1A1X non-polymer         . '2-(2-amino-1H-1,3-benzimidazol-1-yl)-N-(5-ethylpyridin-2-yl)acetamide' ? 'C16 H17 N5 O'   295.339 
ALA   'L-peptide linking' y ALANINE                                                                 ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                                                                ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                              ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                         ? 'C4 H7 N O4'     133.103 
CYS   'L-peptide linking' y CYSTEINE                                                                ? 'C3 H7 N O2 S'   121.158 
DMS   non-polymer         . 'DIMETHYL SULFOXIDE'                                                    ? 'C2 H6 O S'      78.133  
GLN   'L-peptide linking' y GLUTAMINE                                                               ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                         ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                                                                 ? 'C2 H5 N O2'     75.067  
GOL   non-polymer         . GLYCEROL                                                                
'GLYCERIN; PROPANE-1,2,3-TRIOL' 'C3 H8 O3'       92.094  
HIS   'L-peptide linking' y HISTIDINE                                                               ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                                                                   ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                                              ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                                                                 ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                                                                  ? 'C6 H15 N2 O2 1' 147.195 
MET   'L-peptide linking' y METHIONINE                                                              ? 'C5 H11 N O2 S'  149.211 
PHE   'L-peptide linking' y PHENYLALANINE                                                           ? 'C9 H11 N O2'    165.189 
PRO   'L-peptide linking' y PROLINE                                                                 ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                                                                  ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE                                                               ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                              ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                                                ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                                                                  ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ILE 1   363 ?   ?   ?   A . n 
A 1 2   VAL 2   364 364 VAL VAL A . n 
A 1 3   ASP 3   365 365 ASP ASP A . n 
A 1 4   CYS 4   366 366 CYS CYS A . n 
A 1 5   GLY 5   367 367 GLY GLY A . n 
A 1 6   PRO 6   368 368 PRO PRO A . n 
A 1 7   PRO 7   369 369 PRO PRO A . n 
A 1 8   ASP 8   370 370 ASP ASP A . n 
A 1 9   ASP 9   371 371 ASP ASP A . n 
A 1 10  LEU 10  372 372 LEU LEU A . n 
A 1 11  PRO 11  373 373 PRO PRO A . n 
A 1 12  SER 12  374 374 SER SER A . n 
A 1 13  GLY 13  375 375 GLY GLY A . n 
A 1 14  ARG 14  376 376 ARG ARG A . n 
A 1 15  VAL 15  377 377 VAL VAL A . n 
A 1 16  GLU 16  378 378 GLU GLU A . n 
A 1 17  TYR 17  379 379 TYR TYR A . n 
A 1 18  ILE 18  380 380 ILE ILE A . n 
A 1 19  THR 19  381 381 THR THR A . n 
A 1 20  GLY 20  382 382 GLY GLY A . n 
A 1 21  PRO 21  383 383 PRO PRO A . n 
A 1 22  GLY 22  384 384 GLY GLY A . n 
A 1 23  VAL 23  385 385 VAL VAL A . n 
A 1 24  THR 24  386 386 THR THR A . n 
A 1 25  THR 25  387 387 THR THR A . n 
A 1 26  TYR 26  388 388 TYR TYR A . n 
A 1 27  LYS 27  389 389 LYS LYS A . n 
A 1 28  ALA 28  390 390 ALA ALA A . n 
A 1 29  VAL 29  391 391 VAL VAL A . n 
A 1 30  ILE 30  392 392 ILE ILE A . n 
A 1 31  GLN 31  393 393 GLN GLN A . n 
A 1 32  TYR 32  394 394 TYR TYR A . n 
A 1 33  SER 33  395 395 SER SER A . n 
A 1 34  CYS 34  396 396 CYS CYS A . n 
A 1 35  GLU 35  397 397 GLU GLU A . n 
A 1 36  GLU 36  398 398 GLU GLU A . n 
A 1 37  THR 37  399 399 THR THR A . n 
A 1 38  PHE 38  400 400 PHE PHE A . n 
A 1 39  TYR 39  401 401 TYR TYR A . n 
A 1 40  THR 40  402 402 THR THR A . n 
A 1 41  MET 41  403 403 MET MET A . n 
A 1 42  LYS 42  404 404 LYS LYS A . n 
A 1 43  VAL 43  405 405 VAL VAL A . n 
A 1 44  ASN 44  406 406 ASN ASN A . n 
A 1 45  ASP 45  407 407 ASP ASP A . n 
A 1 46  GLY 46  408 408 GLY GLY A . n 
A 1 47  LYS 47  409 409 LYS LYS A . n 
A 1 48  TYR 48  410 410 TYR TYR A . n 
A 1 49  VAL 49  411 411 VAL VAL A . n 
A 1 50  CYS 50  412 412 CYS CYS A . n 
A 1 51  GLU 51  413 413 GLU GLU A . n 
A 1 52  ALA 52  414 414 ALA ALA A . n 
A 1 53  ASP 53  415 415 ASP ASP A . n 
A 1 54  GLY 54  416 416 GLY GLY A . n 
A 1 55  PHE 55  417 417 PHE PHE A . n 
A 1 56  TRP 56  418 418 TRP TRP A . n 
A 1 57  THR 57  419 419 THR THR A . n 
A 1 58  SER 58  420 420 SER SER A . n 
A 1 59  SER 59  421 421 SER SER A . n 
A 1 60  LYS 60  422 422 LYS LYS A . n 
A 1 61  GLY 61  423 423 GLY GLY A . n 
A 1 62  GLU 62  424 424 GLU GLU A . n 
A 1 63  LYS 63  425 425 LYS LYS A . n 
A 1 64  SER 64  426 426 SER SER A . n 
A 1 65  LEU 65  427 427 LEU LEU A . n 
A 1 66  PRO 66  428 428 PRO PRO A . n 
A 1 67  VAL 67  429 429 VAL VAL A . n 
A 1 68  CYS 68  430 430 CYS CYS A . n 
A 1 69  GLU 69  431 431 GLU GLU A . n 
A 1 70  PRO 70  432 432 PRO PRO A . n 
A 1 71  VAL 71  433 433 VAL VAL A . n 
A 1 72  CYS 72  434 434 CYS CYS A . n 
A 1 73  GLY 73  435 435 GLY GLY A . n 
A 1 74  LEU 74  436 436 LEU LEU A . n 
A 1 75  SER 75  437 437 SER SER A . n 
A 1 76  ALA 76  438 438 ALA ALA A . n 
A 1 77  ARG 77  439 439 ARG ARG A . n 
A 1 78  THR 78  440 440 THR THR A . n 
A 1 79  THR 79  441 ?   ?   ?   A . n 
A 1 80  GLY 80  442 ?   ?   ?   A . n 
A 1 81  GLY 81  443 ?   ?   ?   A . n 
A 1 82  ARG 82  444 ?   ?   ?   A . n 
A 1 83  ILE 83  445 445 ILE ILE A . n 
A 1 84  TYR 84  446 446 TYR TYR A . n 
A 1 85  GLY 85  447 447 GLY GLY A . n 
A 1 86  GLY 86  448 448 GLY GLY A . n 
A 1 87  GLN 87  449 449 GLN GLN A . n 
A 1 88  LYS 88  450 450 LYS LYS A . n 
A 1 89  ALA 89  451 451 ALA ALA A . n 
A 1 90  LYS 90  452 452 LYS LYS A . n 
A 1 91  PRO 91  453 453 PRO PRO A . n 
A 1 92  GLY 92  454 454 GLY GLY A . n 
A 1 93  ASP 93  455 455 ASP ASP A . n 
A 1 94  PHE 94  456 456 PHE PHE A . n 
A 1 95  PRO 95  457 457 PRO PRO A . n 
A 1 96  TRP 96  458 458 TRP TRP A . n 
A 1 97  GLN 97  459 459 GLN GLN A . n 
A 1 98  VAL 98  460 460 VAL VAL A . n 
A 1 99  LEU 99  461 461 LEU LEU A . n 
A 1 100 ILE 100 462 462 ILE ILE A . n 
A 1 101 LEU 101 463 463 LEU LEU A . n 
A 1 102 GLY 102 464 464 GLY GLY A . n 
A 1 103 GLY 103 465 465 GLY GLY A . n 
A 1 104 THR 104 466 466 THR THR A . n 
A 1 105 THR 105 467 467 THR THR A . n 
A 1 106 ALA 106 468 468 ALA ALA A . n 
A 1 107 ALA 107 469 469 ALA ALA A . n 
A 1 108 GLY 108 470 470 GLY GLY A . n 
A 1 109 ALA 109 471 471 ALA ALA A . n 
A 1 110 LEU 110 472 472 LEU LEU A . n 
A 1 111 LEU 111 473 473 LEU LEU A . n 
A 1 112 TYR 112 474 474 TYR TYR A . n 
A 1 113 ASP 113 475 475 ASP ASP A . n 
A 1 114 ASN 114 476 476 ASN ASN A . n 
A 1 115 TRP 115 477 477 TRP TRP A . n 
A 1 116 VAL 116 478 478 VAL VAL A . n 
A 1 117 LEU 117 479 479 LEU LEU A . n 
A 1 118 THR 118 480 480 THR THR A . n 
A 1 119 ALA 119 481 481 ALA ALA A . n 
A 1 120 ALA 120 482 482 ALA ALA A . n 
A 1 121 HIS 121 483 483 HIS HIS A . n 
A 1 122 ALA 122 484 484 ALA ALA A . n 
A 1 123 VAL 123 485 485 VAL VAL A . n 
A 1 124 TYR 124 486 486 TYR TYR A . n 
A 1 125 GLU 125 487 487 GLU GLU A . n 
A 1 126 GLN 126 488 488 GLN GLN A . n 
A 1 127 LYS 127 489 489 LYS LYS A . n 
A 1 128 HIS 128 490 490 HIS HIS A . n 
A 1 129 ASP 129 491 491 ASP ASP A . n 
A 1 130 ALA 130 492 492 ALA ALA A . n 
A 1 131 SER 131 493 493 SER SER A . n 
A 1 132 ALA 132 494 494 ALA ALA A . n 
A 1 133 LEU 133 495 495 LEU LEU A . n 
A 1 134 ASP 134 496 496 ASP ASP A . n 
A 1 135 ILE 135 497 497 ILE ILE A . n 
A 1 136 ARG 136 498 498 ARG ARG A . n 
A 1 137 MET 137 499 499 MET MET A . n 
A 1 138 GLY 138 500 500 GLY GLY A . n 
A 1 139 THR 139 501 501 THR THR A . n 
A 1 140 LEU 140 502 502 LEU LEU A . n 
A 1 141 LYS 141 503 503 LYS LYS A . n 
A 1 142 ARG 142 504 504 ARG ARG A . n 
A 1 143 LEU 143 505 505 LEU LEU A . n 
A 1 144 SER 144 506 506 SER SER A . n 
A 1 145 PRO 145 507 507 PRO PRO A . n 
A 1 146 HIS 146 508 508 HIS HIS A . n 
A 1 147 TYR 147 509 509 TYR TYR A . n 
A 1 148 THR 148 510 510 THR THR A . n 
A 1 149 GLN 149 511 511 GLN GLN A . n 
A 1 150 ALA 150 512 512 ALA ALA A . n 
A 1 151 TRP 151 513 513 TRP TRP A . n 
A 1 152 SER 152 514 514 SER SER A . n 
A 1 153 GLU 153 515 515 GLU GLU A . n 
A 1 154 ALA 154 516 516 ALA ALA A . n 
A 1 155 VAL 155 517 517 VAL VAL A . n 
A 1 156 PHE 156 518 518 PHE PHE A . n 
A 1 157 ILE 157 519 519 ILE ILE A . n 
A 1 158 HIS 158 520 520 HIS HIS A . n 
A 1 159 GLU 159 521 521 GLU GLU A . n 
A 1 160 GLY 160 522 522 GLY GLY A . n 
A 1 161 TYR 161 523 523 TYR TYR A . n 
A 1 162 THR 162 524 524 THR THR A . n 
A 1 163 HIS 163 525 525 HIS HIS A . n 
A 1 164 ASP 164 526 526 ASP ASP A . n 
A 1 165 ALA 165 527 527 ALA ALA A . n 
A 1 166 GLY 166 528 528 GLY GLY A . n 
A 1 167 PHE 167 529 529 PHE PHE A . n 
A 1 168 ASP 168 530 530 ASP ASP A . n 
A 1 169 ASN 169 531 531 ASN ASN A . n 
A 1 170 ASP 170 532 532 ASP ASP A . n 
A 1 171 ILE 171 533 533 ILE ILE A . n 
A 1 172 ALA 172 534 534 ALA ALA A . n 
A 1 173 LEU 173 535 535 LEU LEU A . n 
A 1 174 ILE 174 536 536 ILE ILE A . n 
A 1 175 LYS 175 537 537 LYS LYS A . n 
A 1 176 LEU 176 538 538 LEU LEU A . n 
A 1 177 ASN 177 539 539 ASN ASN A . n 
A 1 178 ASN 178 540 540 ASN ASN A . n 
A 1 179 LYS 179 541 541 LYS LYS A . n 
A 1 180 VAL 180 542 542 VAL VAL A . n 
A 1 181 VAL 181 543 543 VAL VAL A . n 
A 1 182 ILE 182 544 544 ILE ILE A . n 
A 1 183 ASN 183 545 545 ASN ASN A . n 
A 1 184 SER 184 546 546 SER SER A . n 
A 1 185 ASN 185 547 547 ASN ASN A . n 
A 1 186 ILE 186 548 548 ILE ILE A . n 
A 1 187 THR 187 549 549 THR THR A . n 
A 1 188 PRO 188 550 550 PRO PRO A . n 
A 1 189 ILE 189 551 551 ILE ILE A . n 
A 1 190 CYS 190 552 552 CYS CYS A . n 
A 1 191 LEU 191 553 553 LEU LEU A . n 
A 1 192 PRO 192 554 554 PRO PRO A . n 
A 1 193 ARG 193 555 555 ARG ARG A . n 
A 1 194 LYS 194 556 556 LYS LYS A . n 
A 1 195 GLU 195 557 557 GLU GLU A . n 
A 1 196 ALA 196 558 558 ALA ALA A . n 
A 1 197 GLU 197 559 559 GLU GLU A . n 
A 1 198 SER 198 560 560 SER SER A . n 
A 1 199 PHE 199 561 561 PHE PHE A . n 
A 1 200 MET 200 562 562 MET MET A . n 
A 1 201 ARG 201 563 563 ARG ARG A . n 
A 1 202 THR 202 564 564 THR THR A . n 
A 1 203 ASP 203 565 565 ASP ASP A . n 
A 1 204 ASP 204 566 566 ASP ASP A . n 
A 1 205 ILE 205 567 567 ILE ILE A . n 
A 1 206 GLY 206 568 568 GLY GLY A . n 
A 1 207 THR 207 569 569 THR THR A . n 
A 1 208 ALA 208 570 570 ALA ALA A . n 
A 1 209 SER 209 571 571 SER SER A . n 
A 1 210 GLY 210 572 572 GLY GLY A . n 
A 1 211 TRP 211 573 573 TRP TRP A . n 
A 1 212 GLY 212 574 574 GLY GLY A . n 
A 1 213 LEU 213 575 575 LEU LEU A . n 
A 1 214 THR 214 576 576 THR THR A . n 
A 1 215 GLN 215 577 577 GLN GLN A . n 
A 1 216 ARG 216 578 578 ARG ARG A . n 
A 1 217 GLY 217 579 579 GLY GLY A . n 
A 1 218 PHE 218 580 580 PHE PHE A . n 
A 1 219 LEU 219 581 581 LEU LEU A . n 
A 1 220 ALA 220 582 582 ALA ALA A . n 
A 1 221 ARG 221 583 583 ARG ARG A . n 
A 1 222 ASN 222 584 584 ASN ASN A . n 
A 1 223 LEU 223 585 585 LEU LEU A . n 
A 1 224 MET 224 586 586 MET MET A . n 
A 1 225 TYR 225 587 587 TYR TYR A . n 
A 1 226 VAL 226 588 588 VAL VAL A . n 
A 1 227 ASP 227 589 589 ASP ASP A . n 
A 1 228 ILE 228 590 590 ILE ILE A . n 
A 1 229 PRO 229 591 591 PRO PRO A . n 
A 1 230 ILE 230 592 592 ILE ILE A . n 
A 1 231 VAL 231 593 593 VAL VAL A . n 
A 1 232 ASP 232 594 594 ASP ASP A . n 
A 1 233 HIS 233 595 595 HIS HIS A . n 
A 1 234 GLN 234 596 596 GLN GLN A . n 
A 1 235 LYS 235 597 597 LYS LYS A . n 
A 1 236 CYS 236 598 598 CYS CYS A . n 
A 1 237 THR 237 599 599 THR THR A . n 
A 1 238 ALA 238 600 600 ALA ALA A . n 
A 1 239 ALA 239 601 601 ALA ALA A . n 
A 1 240 TYR 240 602 602 TYR TYR A . n 
A 1 241 GLU 241 603 603 GLU GLU A . n 
A 1 242 LYS 242 604 604 LYS LYS A . n 
A 1 243 PRO 243 605 605 PRO PRO A . n 
A 1 244 PRO 244 606 606 PRO PRO A . n 
A 1 245 TYR 245 607 607 TYR TYR A . n 
A 1 246 PRO 246 608 608 PRO PRO A . n 
A 1 247 ARG 247 609 609 ARG ARG A . n 
A 1 248 GLY 248 610 610 GLY GLY A . n 
A 1 249 SER 249 611 611 SER SER A . n 
A 1 250 VAL 250 612 612 VAL VAL A . n 
A 1 251 THR 251 613 613 THR THR A . n 
A 1 252 ALA 252 614 614 ALA ALA A . n 
A 1 253 ASN 253 615 615 ASN ASN A . n 
A 1 254 MET 254 616 616 MET MET A . n 
A 1 255 LEU 255 617 617 LEU LEU A . n 
A 1 256 CYS 256 618 618 CYS CYS A . n 
A 1 257 ALA 257 619 619 ALA ALA A . n 
A 1 258 GLY 258 620 620 GLY GLY A . n 
A 1 259 LEU 259 621 621 LEU LEU A . n 
A 1 260 GLU 260 622 622 GLU GLU A . n 
A 1 261 SER 261 623 623 SER SER A . n 
A 1 262 GLY 262 624 624 GLY GLY A . n 
A 1 263 GLY 263 625 625 GLY GLY A . n 
A 1 264 LYS 264 626 626 LYS LYS A . n 
A 1 265 ASP 265 627 627 ASP ASP A . n 
A 1 266 SER 266 628 628 SER SER A . n 
A 1 267 CYS 267 629 629 CYS CYS A . n 
A 1 268 ARG 268 630 630 ARG ARG A . n 
A 1 269 GLY 269 631 631 GLY GLY A . n 
A 1 270 ASP 270 632 632 ASP ASP A . n 
A 1 271 SER 271 633 633 SER SER A . n 
A 1 272 GLY 272 634 634 GLY GLY A . n 
A 1 273 GLY 273 635 635 GLY GLY A . n 
A 1 274 ALA 274 636 636 ALA ALA A . n 
A 1 275 LEU 275 637 637 LEU LEU A . n 
A 1 276 VAL 276 638 638 VAL VAL A . n 
A 1 277 PHE 277 639 639 PHE PHE A . n 
A 1 278 LEU 278 640 640 LEU LEU A . n 
A 1 279 ASP 279 641 641 ASP ASP A . n 
A 1 280 SER 280 642 642 SER SER A . n 
A 1 281 GLU 281 643 643 GLU GLU A . n 
A 1 282 THR 282 644 644 THR THR A . n 
A 1 283 GLU 283 645 645 GLU GLU A . n 
A 1 284 ARG 284 646 646 ARG ARG A . n 
A 1 285 TRP 285 647 647 TRP TRP A . n 
A 1 286 PHE 286 648 648 PHE PHE A . n 
A 1 287 VAL 287 649 649 VAL VAL A . n 
A 1 288 GLY 288 650 650 GLY GLY A . n 
A 1 289 GLY 289 651 651 GLY GLY A . n 
A 1 290 ILE 290 652 652 ILE ILE A . n 
A 1 291 VAL 291 653 653 VAL VAL A . n 
A 1 292 SER 292 654 654 SER SER A . n 
A 1 293 TRP 293 655 655 TRP TRP A . n 
A 1 294 GLY 294 656 656 GLY GLY A . n 
A 1 295 SER 295 657 657 SER SER A . n 
A 1 296 MET 296 658 658 MET MET A . n 
A 1 297 ASN 297 659 659 ASN ASN A . n 
A 1 298 CYS 298 660 660 CYS CYS A . n 
A 1 299 GLY 299 661 661 GLY GLY A . n 
A 1 300 GLU 300 662 662 GLU GLU A . n 
A 1 301 ALA 301 663 663 ALA ALA A . n 
A 1 302 GLY 302 664 664 GLY GLY A . n 
A 1 303 GLN 303 665 665 GLN GLN A . n 
A 1 304 TYR 304 666 666 TYR TYR A . n 
A 1 305 GLY 305 667 667 GLY GLY A . n 
A 1 306 VAL 306 668 668 VAL VAL A . n 
A 1 307 TYR 307 669 669 TYR TYR A . n 
A 1 308 THR 308 670 670 THR THR A . n 
A 1 309 LYS 309 671 671 LYS LYS A . n 
A 1 310 VAL 310 672 672 VAL VAL A . n 
A 1 311 ILE 311 673 673 ILE ILE A . n 
A 1 312 ASN 312 674 674 ASN ASN A . n 
A 1 313 TYR 313 675 675 TYR TYR A . n 
A 1 314 ILE 314 676 676 ILE ILE A . n 
A 1 315 PRO 315 677 677 PRO PRO A . n 
A 1 316 TRP 316 678 678 TRP TRP A . n 
A 1 317 ILE 317 679 679 ILE ILE A . n 
A 1 318 GLU 318 680 680 GLU GLU A . n 
A 1 319 ASN 319 681 681 ASN ASN A . n 
A 1 320 ILE 320 682 682 ILE ILE A . n 
A 1 321 ILE 321 683 683 ILE ILE A . n 
A 1 322 SER 322 684 684 SER SER A . n 
A 1 323 ASP 323 685 685 ASP ASP A . n 
A 1 324 PHE 324 686 686 PHE PHE A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1A1X 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1A1X 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 A1A1X 1  701 1  A1A1X ENI A . 
C 3 GOL   1  702 1  GOL   GOL A . 
D 3 GOL   1  703 2  GOL   GOL A . 
E 4 DMS   1  704 3  DMS   DMS A . 
F 4 DMS   1  705 4  DMS   DMS A . 
G 4 DMS   1  706 5  DMS   DMS A . 
H 5 HOH   1  801 59 HOH   HOH A . 
H 5 HOH   2  802 8  HOH   HOH A . 
H 5 HOH   3  803 48 HOH   HOH A . 
H 5 HOH   4  804 31 HOH   HOH A . 
H 5 HOH   5  805 39 HOH   HOH A . 
H 5 HOH   6  806 24 HOH   HOH A . 
H 5 HOH   7  807 26 HOH   HOH A . 
H 5 HOH   8  808 47 HOH   HOH A . 
H 5 HOH   9  809 21 HOH   HOH A . 
H 5 HOH   10 810 35 HOH   HOH A . 
H 5 HOH   11 811 37 HOH   HOH A . 
H 5 HOH   12 812 36 HOH   HOH A . 
H 5 HOH   13 813 25 HOH   HOH A . 
H 5 HOH   14 814 5  HOH   HOH A . 
H 5 HOH   15 815 55 HOH   HOH A . 
H 5 HOH   16 816 42 HOH   HOH A . 
H 5 HOH   17 817 9  HOH   HOH A . 
H 5 HOH   18 818 19 HOH   HOH A . 
H 5 HOH   19 819 15 HOH   HOH A . 
H 5 HOH   20 820 49 HOH   HOH A . 
H 5 HOH   21 821 23 HOH   HOH A . 
H 5 HOH   22 822 40 HOH   HOH A . 
H 5 HOH   23 823 10 HOH   HOH A . 
H 5 HOH   24 824 41 HOH   HOH A . 
H 5 HOH   25 825 6  HOH   HOH A . 
H 5 HOH   26 826 12 HOH   HOH A . 
H 5 HOH   27 827 30 HOH   HOH A . 
H 5 HOH   28 828 43 HOH   HOH A . 
H 5 HOH   29 829 20 HOH   HOH A . 
H 5 HOH   30 830 60 HOH   HOH A . 
H 5 HOH   31 831 52 HOH   HOH A . 
H 5 HOH   32 832 29 HOH   HOH A . 
H 5 HOH   33 833 16 HOH   HOH A . 
H 5 HOH   34 834 17 HOH   HOH A . 
H 5 HOH   35 835 34 HOH   HOH A . 
H 5 HOH   36 836 51 HOH   HOH A . 
H 5 HOH   37 837 53 HOH   HOH A . 
H 5 HOH   38 838 13 HOH   HOH A . 
H 5 HOH   39 839 45 HOH   HOH A . 
H 5 HOH   40 840 22 HOH   HOH A . 
H 5 HOH   41 841 57 HOH   HOH A . 
H 5 HOH   42 842 33 HOH   HOH A . 
H 5 HOH   43 843 27 HOH   HOH A . 
H 5 HOH   44 844 4  HOH   HOH A . 
H 5 HOH   45 845 3  HOH   HOH A . 
H 5 HOH   46 846 32 HOH   HOH A . 
H 5 HOH   47 847 50 HOH   HOH A . 
H 5 HOH   48 848 14 HOH   HOH A . 
H 5 HOH   49 849 2  HOH   HOH A . 
H 5 HOH   50 850 18 HOH   HOH A . 
H 5 HOH   51 851 46 HOH   HOH A . 
H 5 HOH   52 852 28 HOH   HOH A . 
H 5 HOH   53 853 11 HOH   HOH A . 
H 5 HOH   54 854 1  HOH   HOH A . 
H 5 HOH   55 855 7  HOH   HOH A . 
H 5 HOH   56 856 38 HOH   HOH A . 
H 5 HOH   57 857 44 HOH   HOH A . 
H 5 HOH   58 858 54 HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A VAL 364 ? CG1 ? A VAL 2  CG1 
2 1 Y 1 A VAL 364 ? CG2 ? A VAL 2  CG2 
3 1 Y 1 A PHE 417 ? CG  ? A PHE 55 CG  
4 1 Y 1 A PHE 417 ? CD1 ? A PHE 55 CD1 
5 1 Y 1 A PHE 417 ? CD2 ? A PHE 55 CD2 
6 1 Y 1 A PHE 417 ? CE1 ? A PHE 55 CE1 
7 1 Y 1 A PHE 417 ? CE2 ? A PHE 55 CE2 
8 1 Y 1 A PHE 417 ? CZ  ? A PHE 55 CZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? xia2   ? ? ? .           2 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           3 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   97.520 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9D17 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     71.840 
_cell.length_a_esd                 ? 
_cell.length_b                     40.810 
_cell.length_b_esd                 ? 
_cell.length_c                     101.500 
_cell.length_c_esd                 ? 
_cell.volume                       295017.339 
_cell.volume_esd                   ? 
_cell.Z_PDB                        4 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9D17 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                5 
_symmetry.space_group_name_Hall            'C 2y' 
_symmetry.space_group_name_H-M             'C 1 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9D17 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.09 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.02 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;1.5 uL of protein (0.58 mg/mL MASP2) was mixed with 1.5 uL of reservoir solution (0.1 M Tris-HCl pH 7.5, 0.2 M NaCl, 30% (w/v) PEG 6000, 10% (v/v) glycerol) and equilibrated against reservoir at 20 C. Crystals were soaked in reservoir supplemented with 20% (v/v) glycerol and 1 mM Compound S1
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 9M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-06-23 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.95375 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'CLSI BEAMLINE 08ID-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.95375 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   08ID-1 
_diffrn_source.pdbx_synchrotron_site       CLSI 
# 
_reflns.B_iso_Wilson_estimate                          31.44 
_reflns.entry_id                                       9D17 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.97 
_reflns.d_resolution_low                               35.61 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     20876 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.70 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          6.60 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.994 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.1458 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.97 
_reflns_shell.d_res_low                                     2.04 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.00 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2068 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.311 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.76 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.543 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               39.40 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9D17 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.97 
_refine.ls_d_res_low                             35.61 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20876 
_refine.ls_number_reflns_R_free                  1029 
_refine.ls_number_reflns_R_work                  19843 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.70 
_refine.ls_percent_reflns_R_free                 4.93 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       0.2432 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2011 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.97 
_refine_hist.d_res_low                        35.61 
_refine_hist.number_atoms_solvent             58 
_refine_hist.number_atoms_total               2547 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2443 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         46 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.97 2.07  . . 130 2827 99.76 . . . . 0.2904 . . . . . . . . . . . 0.2964 
'X-RAY DIFFRACTION' 2.07 2.20  . . 168 2766 99.90 . . . . 0.2555 . . . . . . . . . . . 0.2925 
'X-RAY DIFFRACTION' 2.20 2.37  . . 135 2827 99.76 . . . . 0.2327 . . . . . . . . . . . 0.3023 
'X-RAY DIFFRACTION' 2.37 2.61  . . 146 2828 99.90 . . . . 0.2166 . . . . . . . . . . . 0.2311 
'X-RAY DIFFRACTION' 2.61 2.99  . . 160 2831 99.93 . . . . 0.2106 . . . . . . . . . . . 0.2552 
'X-RAY DIFFRACTION' 2.99 3.77  . . 125 2884 99.57 . . . . 0.1829 . . . . . . . . . . . 0.2123 
'X-RAY DIFFRACTION' 3.77 35.61 . . 165 2880 99.22 . . . . 0.1759 . . . . . . . . . . . 0.2323 
# 
_struct.entry_id                     9D17 
_struct.title                        
'Crystal structure of the catalytic region of human MASP-2 with specific inhibitor Compound S1' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9D17 
_struct_keywords.text            'Inhibitor, MASP2, hydrolase' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    MASP2_HUMAN 
_struct_ref.pdbx_db_accession          O00187 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;IVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTG
GRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEG
YTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAY
EKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENI
ISDF
;
_struct_ref.pdbx_align_begin           363 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9D17 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 324 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O00187 
_struct_ref_seq.db_align_beg                  363 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  686 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       363 
_struct_ref_seq.pdbx_auth_seq_align_end       686 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ALA A 119 ? ASP A 129 ? ALA A 481 ASP A 491 1 ? 11 
HELX_P HELX_P2 AA2 ARG A 193 ? MET A 200 ? ARG A 555 MET A 562 5 ? 8  
HELX_P HELX_P3 AA3 ASP A 232 ? TYR A 240 ? ASP A 594 TYR A 602 1 ? 9  
HELX_P HELX_P4 AA4 TYR A 313 ? PHE A 324 ? TYR A 675 PHE A 686 1 ? 12 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 4   SG ? ? ? 1_555 A CYS 50  SG ? ? A CYS 366 A CYS 412 1_555 ? ? ? ? ? ? ? 2.023 ? ? 
disulf2 disulf ? ? A CYS 34  SG ? ? ? 1_555 A CYS 68  SG ? ? A CYS 396 A CYS 430 1_555 ? ? ? ? ? ? ? 2.009 ? ? 
disulf3 disulf ? ? A CYS 72  SG ? ? ? 1_555 A CYS 190 SG ? ? A CYS 434 A CYS 552 1_555 ? ? ? ? ? ? ? 2.059 ? ? 
disulf4 disulf ? ? A CYS 236 SG ? ? ? 1_555 A CYS 256 SG ? ? A CYS 598 A CYS 618 1_555 ? ? ? ? ? ? ? 2.002 ? ? 
disulf5 disulf ? ? A CYS 267 SG ? ? ? 1_555 A CYS 298 SG ? ? A CYS 629 A CYS 660 1_555 ? ? ? ? ? ? ? 2.019 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 4   ? CYS A 50  ? CYS A 366 ? 1_555 CYS A 412 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 34  ? CYS A 68  ? CYS A 396 ? 1_555 CYS A 430 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 72  ? CYS A 190 ? CYS A 434 ? 1_555 CYS A 552 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 236 ? CYS A 256 ? CYS A 598 ? 1_555 CYS A 618 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS A 267 ? CYS A 298 ? CYS A 629 ? 1_555 CYS A 660 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          PRO 
_struct_mon_prot_cis.label_seq_id           243 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           PRO 
_struct_mon_prot_cis.auth_seq_id            605 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    244 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     606 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       0.49 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 8 ? 
AA4 ? 7 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA3 4 5 ? anti-parallel 
AA3 5 6 ? anti-parallel 
AA3 6 7 ? anti-parallel 
AA3 7 8 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA4 4 5 ? anti-parallel 
AA4 5 6 ? anti-parallel 
AA4 6 7 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLY A 13  ? TYR A 17  ? GLY A 375 TYR A 379 
AA1 2 VAL A 29  ? CYS A 34  ? VAL A 391 CYS A 396 
AA1 3 LYS A 47  ? CYS A 50  ? LYS A 409 CYS A 412 
AA1 4 TRP A 56  ? SER A 58  ? TRP A 418 SER A 420 
AA2 1 TYR A 39  ? LYS A 42  ? TYR A 401 LYS A 404 
AA2 2 VAL A 67  ? PRO A 70  ? VAL A 429 PRO A 432 
AA3 1 GLN A 87  ? LYS A 88  ? GLN A 449 LYS A 450 
AA3 2 MET A 224 ? VAL A 231 ? MET A 586 VAL A 593 
AA3 3 MET A 254 ? ALA A 257 ? MET A 616 ALA A 619 
AA3 4 GLY A 305 ? LYS A 309 ? GLY A 667 LYS A 671 
AA3 5 ARG A 284 ? TRP A 293 ? ARG A 646 TRP A 655 
AA3 6 ALA A 274 ? ASP A 279 ? ALA A 636 ASP A 641 
AA3 7 ILE A 205 ? GLY A 210 ? ILE A 567 GLY A 572 
AA3 8 MET A 224 ? VAL A 231 ? MET A 586 VAL A 593 
AA4 1 GLN A 97  ? LEU A 101 ? GLN A 459 LEU A 463 
AA4 2 ALA A 106 ? LEU A 111 ? ALA A 468 LEU A 473 
AA4 3 TRP A 115 ? THR A 118 ? TRP A 477 THR A 480 
AA4 4 ALA A 172 ? LEU A 176 ? ALA A 534 LEU A 538 
AA4 5 THR A 148 ? ILE A 157 ? THR A 510 ILE A 519 
AA4 6 ASP A 134 ? MET A 137 ? ASP A 496 MET A 499 
AA4 7 GLN A 97  ? LEU A 101 ? GLN A 459 LEU A 463 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLU A 16  ? N GLU A 378 O GLN A 31  ? O GLN A 393 
AA1 2 3 N ILE A 30  ? N ILE A 392 O TYR A 48  ? O TYR A 410 
AA1 3 4 N VAL A 49  ? N VAL A 411 O THR A 57  ? O THR A 419 
AA2 1 2 N LYS A 42  ? N LYS A 404 O VAL A 67  ? O VAL A 429 
AA3 1 2 N GLN A 87  ? N GLN A 449 O TYR A 225 ? O TYR A 587 
AA3 2 3 N VAL A 231 ? N VAL A 593 O CYS A 256 ? O CYS A 618 
AA3 3 4 N LEU A 255 ? N LEU A 617 O TYR A 307 ? O TYR A 669 
AA3 4 5 O VAL A 306 ? O VAL A 668 N TRP A 293 ? N TRP A 655 
AA3 5 6 O GLY A 289 ? O GLY A 651 N LEU A 275 ? N LEU A 637 
AA3 6 7 O VAL A 276 ? O VAL A 638 N THR A 207 ? N THR A 569 
AA3 7 8 N GLY A 206 ? N GLY A 568 O ILE A 228 ? O ILE A 590 
AA4 1 2 N VAL A 98  ? N VAL A 460 O GLY A 108 ? O GLY A 470 
AA4 2 3 N LEU A 111 ? N LEU A 473 O TRP A 115 ? O TRP A 477 
AA4 3 4 N THR A 118 ? N THR A 480 O ALA A 172 ? O ALA A 534 
AA4 4 5 O LYS A 175 ? O LYS A 537 N GLU A 153 ? N GLU A 515 
AA4 5 6 O THR A 148 ? O THR A 510 N MET A 137 ? N MET A 499 
AA4 6 7 O ARG A 136 ? O ARG A 498 N LEU A 99  ? N LEU A 461 
# 
_pdbx_entry_details.entry_id                   9D17 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OE1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   GLU 
_pdbx_validate_close_contact.auth_seq_id_1    398 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   HOH 
_pdbx_validate_close_contact.auth_seq_id_2    801 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.17 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 PRO A 383 ? ? -54.94  108.47  
2 1 VAL A 405 ? ? 86.39   -67.92  
3 1 THR A 466 ? ? 60.37   166.31  
4 1 TYR A 474 ? ? 57.89   -137.92 
5 1 ASN A 476 ? ? -151.20 16.51   
6 1 ASP A 565 ? ? 81.34   -4.86   
7 1 SER A 633 ? ? -38.60  132.68  
8 1 SER A 654 ? ? -120.23 -70.19  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 -x,y,-z         
3 x+1/2,y+1/2,z   
4 -x+1/2,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A ILE 363 ? A ILE 1  
2 1 Y 1 A THR 441 ? A THR 79 
3 1 Y 1 A GLY 442 ? A GLY 80 
4 1 Y 1 A GLY 443 ? A GLY 81 
5 1 Y 1 A ARG 444 ? A ARG 82 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1A1X C13  C Y N 1   
A1A1X C15  C Y N 2   
A1A1X C11  C Y N 3   
A1A1X C12  C Y N 4   
A1A1X C14  C Y N 5   
A1A1X C16  C Y N 6   
A1A1X C1   C N N 7   
A1A1X C10  C Y N 8   
A1A1X C2   C N N 9   
A1A1X C3   C Y N 10  
A1A1X C4   C Y N 11  
A1A1X C5   C Y N 12  
A1A1X C6   C N N 13  
A1A1X C7   C N N 14  
A1A1X C8   C Y N 15  
A1A1X C9   C Y N 16  
A1A1X N1   N Y N 17  
A1A1X N2   N N N 18  
A1A1X N3   N Y N 19  
A1A1X N4   N Y N 20  
A1A1X N5   N N N 21  
A1A1X O1   O N N 22  
A1A1X HC13 H N N 23  
A1A1X HC15 H N N 24  
A1A1X HC11 H N N 25  
A1A1X HC12 H N N 26  
A1A1X HC14 H N N 27  
A1A1X HC16 H N N 28  
A1A1X H1_3 H N N 29  
A1A1X H1_2 H N N 30  
A1A1X H1_1 H N N 31  
A1A1X H2_1 H N N 32  
A1A1X H2_2 H N N 33  
A1A1X HC4  H N N 34  
A1A1X H7_2 H N N 35  
A1A1X H7_1 H N N 36  
A1A1X HN2  H N N 37  
A1A1X H5_1 H N N 38  
A1A1X H5_2 H N N 39  
ALA   N    N N N 40  
ALA   CA   C N S 41  
ALA   C    C N N 42  
ALA   O    O N N 43  
ALA   CB   C N N 44  
ALA   OXT  O N N 45  
ALA   H    H N N 46  
ALA   H2   H N N 47  
ALA   HA   H N N 48  
ALA   HB1  H N N 49  
ALA   HB2  H N N 50  
ALA   HB3  H N N 51  
ALA   HXT  H N N 52  
ARG   N    N N N 53  
ARG   CA   C N S 54  
ARG   C    C N N 55  
ARG   O    O N N 56  
ARG   CB   C N N 57  
ARG   CG   C N N 58  
ARG   CD   C N N 59  
ARG   NE   N N N 60  
ARG   CZ   C N N 61  
ARG   NH1  N N N 62  
ARG   NH2  N N N 63  
ARG   OXT  O N N 64  
ARG   H    H N N 65  
ARG   H2   H N N 66  
ARG   HA   H N N 67  
ARG   HB2  H N N 68  
ARG   HB3  H N N 69  
ARG   HG2  H N N 70  
ARG   HG3  H N N 71  
ARG   HD2  H N N 72  
ARG   HD3  H N N 73  
ARG   HE   H N N 74  
ARG   HH11 H N N 75  
ARG   HH12 H N N 76  
ARG   HH21 H N N 77  
ARG   HH22 H N N 78  
ARG   HXT  H N N 79  
ASN   N    N N N 80  
ASN   CA   C N S 81  
ASN   C    C N N 82  
ASN   O    O N N 83  
ASN   CB   C N N 84  
ASN   CG   C N N 85  
ASN   OD1  O N N 86  
ASN   ND2  N N N 87  
ASN   OXT  O N N 88  
ASN   H    H N N 89  
ASN   H2   H N N 90  
ASN   HA   H N N 91  
ASN   HB2  H N N 92  
ASN   HB3  H N N 93  
ASN   HD21 H N N 94  
ASN   HD22 H N N 95  
ASN   HXT  H N N 96  
ASP   N    N N N 97  
ASP   CA   C N S 98  
ASP   C    C N N 99  
ASP   O    O N N 100 
ASP   CB   C N N 101 
ASP   CG   C N N 102 
ASP   OD1  O N N 103 
ASP   OD2  O N N 104 
ASP   OXT  O N N 105 
ASP   H    H N N 106 
ASP   H2   H N N 107 
ASP   HA   H N N 108 
ASP   HB2  H N N 109 
ASP   HB3  H N N 110 
ASP   HD2  H N N 111 
ASP   HXT  H N N 112 
CYS   N    N N N 113 
CYS   CA   C N R 114 
CYS   C    C N N 115 
CYS   O    O N N 116 
CYS   CB   C N N 117 
CYS   SG   S N N 118 
CYS   OXT  O N N 119 
CYS   H    H N N 120 
CYS   H2   H N N 121 
CYS   HA   H N N 122 
CYS   HB2  H N N 123 
CYS   HB3  H N N 124 
CYS   HG   H N N 125 
CYS   HXT  H N N 126 
DMS   S    S N N 127 
DMS   O    O N N 128 
DMS   C1   C N N 129 
DMS   C2   C N N 130 
DMS   H11  H N N 131 
DMS   H12  H N N 132 
DMS   H13  H N N 133 
DMS   H21  H N N 134 
DMS   H22  H N N 135 
DMS   H23  H N N 136 
GLN   N    N N N 137 
GLN   CA   C N S 138 
GLN   C    C N N 139 
GLN   O    O N N 140 
GLN   CB   C N N 141 
GLN   CG   C N N 142 
GLN   CD   C N N 143 
GLN   OE1  O N N 144 
GLN   NE2  N N N 145 
GLN   OXT  O N N 146 
GLN   H    H N N 147 
GLN   H2   H N N 148 
GLN   HA   H N N 149 
GLN   HB2  H N N 150 
GLN   HB3  H N N 151 
GLN   HG2  H N N 152 
GLN   HG3  H N N 153 
GLN   HE21 H N N 154 
GLN   HE22 H N N 155 
GLN   HXT  H N N 156 
GLU   N    N N N 157 
GLU   CA   C N S 158 
GLU   C    C N N 159 
GLU   O    O N N 160 
GLU   CB   C N N 161 
GLU   CG   C N N 162 
GLU   CD   C N N 163 
GLU   OE1  O N N 164 
GLU   OE2  O N N 165 
GLU   OXT  O N N 166 
GLU   H    H N N 167 
GLU   H2   H N N 168 
GLU   HA   H N N 169 
GLU   HB2  H N N 170 
GLU   HB3  H N N 171 
GLU   HG2  H N N 172 
GLU   HG3  H N N 173 
GLU   HE2  H N N 174 
GLU   HXT  H N N 175 
GLY   N    N N N 176 
GLY   CA   C N N 177 
GLY   C    C N N 178 
GLY   O    O N N 179 
GLY   OXT  O N N 180 
GLY   H    H N N 181 
GLY   H2   H N N 182 
GLY   HA2  H N N 183 
GLY   HA3  H N N 184 
GLY   HXT  H N N 185 
GOL   C1   C N N 186 
GOL   O1   O N N 187 
GOL   C2   C N N 188 
GOL   O2   O N N 189 
GOL   C3   C N N 190 
GOL   O3   O N N 191 
GOL   H11  H N N 192 
GOL   H12  H N N 193 
GOL   HO1  H N N 194 
GOL   H2   H N N 195 
GOL   HO2  H N N 196 
GOL   H31  H N N 197 
GOL   H32  H N N 198 
GOL   HO3  H N N 199 
HIS   N    N N N 200 
HIS   CA   C N S 201 
HIS   C    C N N 202 
HIS   O    O N N 203 
HIS   CB   C N N 204 
HIS   CG   C Y N 205 
HIS   ND1  N Y N 206 
HIS   CD2  C Y N 207 
HIS   CE1  C Y N 208 
HIS   NE2  N Y N 209 
HIS   OXT  O N N 210 
HIS   H    H N N 211 
HIS   H2   H N N 212 
HIS   HA   H N N 213 
HIS   HB2  H N N 214 
HIS   HB3  H N N 215 
HIS   HD1  H N N 216 
HIS   HD2  H N N 217 
HIS   HE1  H N N 218 
HIS   HE2  H N N 219 
HIS   HXT  H N N 220 
HOH   O    O N N 221 
HOH   H1   H N N 222 
HOH   H2   H N N 223 
ILE   N    N N N 224 
ILE   CA   C N S 225 
ILE   C    C N N 226 
ILE   O    O N N 227 
ILE   CB   C N S 228 
ILE   CG1  C N N 229 
ILE   CG2  C N N 230 
ILE   CD1  C N N 231 
ILE   OXT  O N N 232 
ILE   H    H N N 233 
ILE   H2   H N N 234 
ILE   HA   H N N 235 
ILE   HB   H N N 236 
ILE   HG12 H N N 237 
ILE   HG13 H N N 238 
ILE   HG21 H N N 239 
ILE   HG22 H N N 240 
ILE   HG23 H N N 241 
ILE   HD11 H N N 242 
ILE   HD12 H N N 243 
ILE   HD13 H N N 244 
ILE   HXT  H N N 245 
LEU   N    N N N 246 
LEU   CA   C N S 247 
LEU   C    C N N 248 
LEU   O    O N N 249 
LEU   CB   C N N 250 
LEU   CG   C N N 251 
LEU   CD1  C N N 252 
LEU   CD2  C N N 253 
LEU   OXT  O N N 254 
LEU   H    H N N 255 
LEU   H2   H N N 256 
LEU   HA   H N N 257 
LEU   HB2  H N N 258 
LEU   HB3  H N N 259 
LEU   HG   H N N 260 
LEU   HD11 H N N 261 
LEU   HD12 H N N 262 
LEU   HD13 H N N 263 
LEU   HD21 H N N 264 
LEU   HD22 H N N 265 
LEU   HD23 H N N 266 
LEU   HXT  H N N 267 
LYS   N    N N N 268 
LYS   CA   C N S 269 
LYS   C    C N N 270 
LYS   O    O N N 271 
LYS   CB   C N N 272 
LYS   CG   C N N 273 
LYS   CD   C N N 274 
LYS   CE   C N N 275 
LYS   NZ   N N N 276 
LYS   OXT  O N N 277 
LYS   H    H N N 278 
LYS   H2   H N N 279 
LYS   HA   H N N 280 
LYS   HB2  H N N 281 
LYS   HB3  H N N 282 
LYS   HG2  H N N 283 
LYS   HG3  H N N 284 
LYS   HD2  H N N 285 
LYS   HD3  H N N 286 
LYS   HE2  H N N 287 
LYS   HE3  H N N 288 
LYS   HZ1  H N N 289 
LYS   HZ2  H N N 290 
LYS   HZ3  H N N 291 
LYS   HXT  H N N 292 
MET   N    N N N 293 
MET   CA   C N S 294 
MET   C    C N N 295 
MET   O    O N N 296 
MET   CB   C N N 297 
MET   CG   C N N 298 
MET   SD   S N N 299 
MET   CE   C N N 300 
MET   OXT  O N N 301 
MET   H    H N N 302 
MET   H2   H N N 303 
MET   HA   H N N 304 
MET   HB2  H N N 305 
MET   HB3  H N N 306 
MET   HG2  H N N 307 
MET   HG3  H N N 308 
MET   HE1  H N N 309 
MET   HE2  H N N 310 
MET   HE3  H N N 311 
MET   HXT  H N N 312 
PHE   N    N N N 313 
PHE   CA   C N S 314 
PHE   C    C N N 315 
PHE   O    O N N 316 
PHE   CB   C N N 317 
PHE   CG   C Y N 318 
PHE   CD1  C Y N 319 
PHE   CD2  C Y N 320 
PHE   CE1  C Y N 321 
PHE   CE2  C Y N 322 
PHE   CZ   C Y N 323 
PHE   OXT  O N N 324 
PHE   H    H N N 325 
PHE   H2   H N N 326 
PHE   HA   H N N 327 
PHE   HB2  H N N 328 
PHE   HB3  H N N 329 
PHE   HD1  H N N 330 
PHE   HD2  H N N 331 
PHE   HE1  H N N 332 
PHE   HE2  H N N 333 
PHE   HZ   H N N 334 
PHE   HXT  H N N 335 
PRO   N    N N N 336 
PRO   CA   C N S 337 
PRO   C    C N N 338 
PRO   O    O N N 339 
PRO   CB   C N N 340 
PRO   CG   C N N 341 
PRO   CD   C N N 342 
PRO   OXT  O N N 343 
PRO   H    H N N 344 
PRO   HA   H N N 345 
PRO   HB2  H N N 346 
PRO   HB3  H N N 347 
PRO   HG2  H N N 348 
PRO   HG3  H N N 349 
PRO   HD2  H N N 350 
PRO   HD3  H N N 351 
PRO   HXT  H N N 352 
SER   N    N N N 353 
SER   CA   C N S 354 
SER   C    C N N 355 
SER   O    O N N 356 
SER   CB   C N N 357 
SER   OG   O N N 358 
SER   OXT  O N N 359 
SER   H    H N N 360 
SER   H2   H N N 361 
SER   HA   H N N 362 
SER   HB2  H N N 363 
SER   HB3  H N N 364 
SER   HG   H N N 365 
SER   HXT  H N N 366 
THR   N    N N N 367 
THR   CA   C N S 368 
THR   C    C N N 369 
THR   O    O N N 370 
THR   CB   C N R 371 
THR   OG1  O N N 372 
THR   CG2  C N N 373 
THR   OXT  O N N 374 
THR   H    H N N 375 
THR   H2   H N N 376 
THR   HA   H N N 377 
THR   HB   H N N 378 
THR   HG1  H N N 379 
THR   HG21 H N N 380 
THR   HG22 H N N 381 
THR   HG23 H N N 382 
THR   HXT  H N N 383 
TRP   N    N N N 384 
TRP   CA   C N S 385 
TRP   C    C N N 386 
TRP   O    O N N 387 
TRP   CB   C N N 388 
TRP   CG   C Y N 389 
TRP   CD1  C Y N 390 
TRP   CD2  C Y N 391 
TRP   NE1  N Y N 392 
TRP   CE2  C Y N 393 
TRP   CE3  C Y N 394 
TRP   CZ2  C Y N 395 
TRP   CZ3  C Y N 396 
TRP   CH2  C Y N 397 
TRP   OXT  O N N 398 
TRP   H    H N N 399 
TRP   H2   H N N 400 
TRP   HA   H N N 401 
TRP   HB2  H N N 402 
TRP   HB3  H N N 403 
TRP   HD1  H N N 404 
TRP   HE1  H N N 405 
TRP   HE3  H N N 406 
TRP   HZ2  H N N 407 
TRP   HZ3  H N N 408 
TRP   HH2  H N N 409 
TRP   HXT  H N N 410 
TYR   N    N N N 411 
TYR   CA   C N S 412 
TYR   C    C N N 413 
TYR   O    O N N 414 
TYR   CB   C N N 415 
TYR   CG   C Y N 416 
TYR   CD1  C Y N 417 
TYR   CD2  C Y N 418 
TYR   CE1  C Y N 419 
TYR   CE2  C Y N 420 
TYR   CZ   C Y N 421 
TYR   OH   O N N 422 
TYR   OXT  O N N 423 
TYR   H    H N N 424 
TYR   H2   H N N 425 
TYR   HA   H N N 426 
TYR   HB2  H N N 427 
TYR   HB3  H N N 428 
TYR   HD1  H N N 429 
TYR   HD2  H N N 430 
TYR   HE1  H N N 431 
TYR   HE2  H N N 432 
TYR   HH   H N N 433 
TYR   HXT  H N N 434 
VAL   N    N N N 435 
VAL   CA   C N S 436 
VAL   C    C N N 437 
VAL   O    O N N 438 
VAL   CB   C N N 439 
VAL   CG1  C N N 440 
VAL   CG2  C N N 441 
VAL   OXT  O N N 442 
VAL   H    H N N 443 
VAL   H2   H N N 444 
VAL   HA   H N N 445 
VAL   HB   H N N 446 
VAL   HG11 H N N 447 
VAL   HG12 H N N 448 
VAL   HG13 H N N 449 
VAL   HG21 H N N 450 
VAL   HG22 H N N 451 
VAL   HG23 H N N 452 
VAL   HXT  H N N 453 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1A1X C1  C2   sing N N 1   
A1A1X N1  C4   doub Y N 2   
A1A1X N1  C5   sing Y N 3   
A1A1X O1  C6   doub N N 4   
A1A1X C2  C3   sing N N 5   
A1A1X N2  C5   sing N N 6   
A1A1X N2  C6   sing N N 7   
A1A1X C3  C4   sing Y N 8   
A1A1X C3  C16  doub Y N 9   
A1A1X N3  C7   sing N N 10  
A1A1X N3  C8   sing Y N 11  
A1A1X N3  C10  sing Y N 12  
A1A1X N4  C8   doub Y N 13  
A1A1X N4  C9   sing Y N 14  
A1A1X C5  C15  doub Y N 15  
A1A1X N5  C8   sing N N 16  
A1A1X C6  C7   sing N N 17  
A1A1X C9  C10  doub Y N 18  
A1A1X C9  C14  sing Y N 19  
A1A1X C10 C11  sing Y N 20  
A1A1X C11 C12  doub Y N 21  
A1A1X C12 C13  sing Y N 22  
A1A1X C13 C14  doub Y N 23  
A1A1X C15 C16  sing Y N 24  
A1A1X C13 HC13 sing N N 25  
A1A1X C15 HC15 sing N N 26  
A1A1X C11 HC11 sing N N 27  
A1A1X C12 HC12 sing N N 28  
A1A1X C14 HC14 sing N N 29  
A1A1X C16 HC16 sing N N 30  
A1A1X C1  H1_3 sing N N 31  
A1A1X C1  H1_2 sing N N 32  
A1A1X C1  H1_1 sing N N 33  
A1A1X C2  H2_1 sing N N 34  
A1A1X C2  H2_2 sing N N 35  
A1A1X C4  HC4  sing N N 36  
A1A1X C7  H7_2 sing N N 37  
A1A1X C7  H7_1 sing N N 38  
A1A1X N2  HN2  sing N N 39  
A1A1X N5  H5_1 sing N N 40  
A1A1X N5  H5_2 sing N N 41  
ALA   N   CA   sing N N 42  
ALA   N   H    sing N N 43  
ALA   N   H2   sing N N 44  
ALA   CA  C    sing N N 45  
ALA   CA  CB   sing N N 46  
ALA   CA  HA   sing N N 47  
ALA   C   O    doub N N 48  
ALA   C   OXT  sing N N 49  
ALA   CB  HB1  sing N N 50  
ALA   CB  HB2  sing N N 51  
ALA   CB  HB3  sing N N 52  
ALA   OXT HXT  sing N N 53  
ARG   N   CA   sing N N 54  
ARG   N   H    sing N N 55  
ARG   N   H2   sing N N 56  
ARG   CA  C    sing N N 57  
ARG   CA  CB   sing N N 58  
ARG   CA  HA   sing N N 59  
ARG   C   O    doub N N 60  
ARG   C   OXT  sing N N 61  
ARG   CB  CG   sing N N 62  
ARG   CB  HB2  sing N N 63  
ARG   CB  HB3  sing N N 64  
ARG   CG  CD   sing N N 65  
ARG   CG  HG2  sing N N 66  
ARG   CG  HG3  sing N N 67  
ARG   CD  NE   sing N N 68  
ARG   CD  HD2  sing N N 69  
ARG   CD  HD3  sing N N 70  
ARG   NE  CZ   sing N N 71  
ARG   NE  HE   sing N N 72  
ARG   CZ  NH1  sing N N 73  
ARG   CZ  NH2  doub N N 74  
ARG   NH1 HH11 sing N N 75  
ARG   NH1 HH12 sing N N 76  
ARG   NH2 HH21 sing N N 77  
ARG   NH2 HH22 sing N N 78  
ARG   OXT HXT  sing N N 79  
ASN   N   CA   sing N N 80  
ASN   N   H    sing N N 81  
ASN   N   H2   sing N N 82  
ASN   CA  C    sing N N 83  
ASN   CA  CB   sing N N 84  
ASN   CA  HA   sing N N 85  
ASN   C   O    doub N N 86  
ASN   C   OXT  sing N N 87  
ASN   CB  CG   sing N N 88  
ASN   CB  HB2  sing N N 89  
ASN   CB  HB3  sing N N 90  
ASN   CG  OD1  doub N N 91  
ASN   CG  ND2  sing N N 92  
ASN   ND2 HD21 sing N N 93  
ASN   ND2 HD22 sing N N 94  
ASN   OXT HXT  sing N N 95  
ASP   N   CA   sing N N 96  
ASP   N   H    sing N N 97  
ASP   N   H2   sing N N 98  
ASP   CA  C    sing N N 99  
ASP   CA  CB   sing N N 100 
ASP   CA  HA   sing N N 101 
ASP   C   O    doub N N 102 
ASP   C   OXT  sing N N 103 
ASP   CB  CG   sing N N 104 
ASP   CB  HB2  sing N N 105 
ASP   CB  HB3  sing N N 106 
ASP   CG  OD1  doub N N 107 
ASP   CG  OD2  sing N N 108 
ASP   OD2 HD2  sing N N 109 
ASP   OXT HXT  sing N N 110 
CYS   N   CA   sing N N 111 
CYS   N   H    sing N N 112 
CYS   N   H2   sing N N 113 
CYS   CA  C    sing N N 114 
CYS   CA  CB   sing N N 115 
CYS   CA  HA   sing N N 116 
CYS   C   O    doub N N 117 
CYS   C   OXT  sing N N 118 
CYS   CB  SG   sing N N 119 
CYS   CB  HB2  sing N N 120 
CYS   CB  HB3  sing N N 121 
CYS   SG  HG   sing N N 122 
CYS   OXT HXT  sing N N 123 
DMS   S   O    doub N N 124 
DMS   S   C1   sing N N 125 
DMS   S   C2   sing N N 126 
DMS   C1  H11  sing N N 127 
DMS   C1  H12  sing N N 128 
DMS   C1  H13  sing N N 129 
DMS   C2  H21  sing N N 130 
DMS   C2  H22  sing N N 131 
DMS   C2  H23  sing N N 132 
GLN   N   CA   sing N N 133 
GLN   N   H    sing N N 134 
GLN   N   H2   sing N N 135 
GLN   CA  C    sing N N 136 
GLN   CA  CB   sing N N 137 
GLN   CA  HA   sing N N 138 
GLN   C   O    doub N N 139 
GLN   C   OXT  sing N N 140 
GLN   CB  CG   sing N N 141 
GLN   CB  HB2  sing N N 142 
GLN   CB  HB3  sing N N 143 
GLN   CG  CD   sing N N 144 
GLN   CG  HG2  sing N N 145 
GLN   CG  HG3  sing N N 146 
GLN   CD  OE1  doub N N 147 
GLN   CD  NE2  sing N N 148 
GLN   NE2 HE21 sing N N 149 
GLN   NE2 HE22 sing N N 150 
GLN   OXT HXT  sing N N 151 
GLU   N   CA   sing N N 152 
GLU   N   H    sing N N 153 
GLU   N   H2   sing N N 154 
GLU   CA  C    sing N N 155 
GLU   CA  CB   sing N N 156 
GLU   CA  HA   sing N N 157 
GLU   C   O    doub N N 158 
GLU   C   OXT  sing N N 159 
GLU   CB  CG   sing N N 160 
GLU   CB  HB2  sing N N 161 
GLU   CB  HB3  sing N N 162 
GLU   CG  CD   sing N N 163 
GLU   CG  HG2  sing N N 164 
GLU   CG  HG3  sing N N 165 
GLU   CD  OE1  doub N N 166 
GLU   CD  OE2  sing N N 167 
GLU   OE2 HE2  sing N N 168 
GLU   OXT HXT  sing N N 169 
GLY   N   CA   sing N N 170 
GLY   N   H    sing N N 171 
GLY   N   H2   sing N N 172 
GLY   CA  C    sing N N 173 
GLY   CA  HA2  sing N N 174 
GLY   CA  HA3  sing N N 175 
GLY   C   O    doub N N 176 
GLY   C   OXT  sing N N 177 
GLY   OXT HXT  sing N N 178 
GOL   C1  O1   sing N N 179 
GOL   C1  C2   sing N N 180 
GOL   C1  H11  sing N N 181 
GOL   C1  H12  sing N N 182 
GOL   O1  HO1  sing N N 183 
GOL   C2  O2   sing N N 184 
GOL   C2  C3   sing N N 185 
GOL   C2  H2   sing N N 186 
GOL   O2  HO2  sing N N 187 
GOL   C3  O3   sing N N 188 
GOL   C3  H31  sing N N 189 
GOL   C3  H32  sing N N 190 
GOL   O3  HO3  sing N N 191 
HIS   N   CA   sing N N 192 
HIS   N   H    sing N N 193 
HIS   N   H2   sing N N 194 
HIS   CA  C    sing N N 195 
HIS   CA  CB   sing N N 196 
HIS   CA  HA   sing N N 197 
HIS   C   O    doub N N 198 
HIS   C   OXT  sing N N 199 
HIS   CB  CG   sing N N 200 
HIS   CB  HB2  sing N N 201 
HIS   CB  HB3  sing N N 202 
HIS   CG  ND1  sing Y N 203 
HIS   CG  CD2  doub Y N 204 
HIS   ND1 CE1  doub Y N 205 
HIS   ND1 HD1  sing N N 206 
HIS   CD2 NE2  sing Y N 207 
HIS   CD2 HD2  sing N N 208 
HIS   CE1 NE2  sing Y N 209 
HIS   CE1 HE1  sing N N 210 
HIS   NE2 HE2  sing N N 211 
HIS   OXT HXT  sing N N 212 
HOH   O   H1   sing N N 213 
HOH   O   H2   sing N N 214 
ILE   N   CA   sing N N 215 
ILE   N   H    sing N N 216 
ILE   N   H2   sing N N 217 
ILE   CA  C    sing N N 218 
ILE   CA  CB   sing N N 219 
ILE   CA  HA   sing N N 220 
ILE   C   O    doub N N 221 
ILE   C   OXT  sing N N 222 
ILE   CB  CG1  sing N N 223 
ILE   CB  CG2  sing N N 224 
ILE   CB  HB   sing N N 225 
ILE   CG1 CD1  sing N N 226 
ILE   CG1 HG12 sing N N 227 
ILE   CG1 HG13 sing N N 228 
ILE   CG2 HG21 sing N N 229 
ILE   CG2 HG22 sing N N 230 
ILE   CG2 HG23 sing N N 231 
ILE   CD1 HD11 sing N N 232 
ILE   CD1 HD12 sing N N 233 
ILE   CD1 HD13 sing N N 234 
ILE   OXT HXT  sing N N 235 
LEU   N   CA   sing N N 236 
LEU   N   H    sing N N 237 
LEU   N   H2   sing N N 238 
LEU   CA  C    sing N N 239 
LEU   CA  CB   sing N N 240 
LEU   CA  HA   sing N N 241 
LEU   C   O    doub N N 242 
LEU   C   OXT  sing N N 243 
LEU   CB  CG   sing N N 244 
LEU   CB  HB2  sing N N 245 
LEU   CB  HB3  sing N N 246 
LEU   CG  CD1  sing N N 247 
LEU   CG  CD2  sing N N 248 
LEU   CG  HG   sing N N 249 
LEU   CD1 HD11 sing N N 250 
LEU   CD1 HD12 sing N N 251 
LEU   CD1 HD13 sing N N 252 
LEU   CD2 HD21 sing N N 253 
LEU   CD2 HD22 sing N N 254 
LEU   CD2 HD23 sing N N 255 
LEU   OXT HXT  sing N N 256 
LYS   N   CA   sing N N 257 
LYS   N   H    sing N N 258 
LYS   N   H2   sing N N 259 
LYS   CA  C    sing N N 260 
LYS   CA  CB   sing N N 261 
LYS   CA  HA   sing N N 262 
LYS   C   O    doub N N 263 
LYS   C   OXT  sing N N 264 
LYS   CB  CG   sing N N 265 
LYS   CB  HB2  sing N N 266 
LYS   CB  HB3  sing N N 267 
LYS   CG  CD   sing N N 268 
LYS   CG  HG2  sing N N 269 
LYS   CG  HG3  sing N N 270 
LYS   CD  CE   sing N N 271 
LYS   CD  HD2  sing N N 272 
LYS   CD  HD3  sing N N 273 
LYS   CE  NZ   sing N N 274 
LYS   CE  HE2  sing N N 275 
LYS   CE  HE3  sing N N 276 
LYS   NZ  HZ1  sing N N 277 
LYS   NZ  HZ2  sing N N 278 
LYS   NZ  HZ3  sing N N 279 
LYS   OXT HXT  sing N N 280 
MET   N   CA   sing N N 281 
MET   N   H    sing N N 282 
MET   N   H2   sing N N 283 
MET   CA  C    sing N N 284 
MET   CA  CB   sing N N 285 
MET   CA  HA   sing N N 286 
MET   C   O    doub N N 287 
MET   C   OXT  sing N N 288 
MET   CB  CG   sing N N 289 
MET   CB  HB2  sing N N 290 
MET   CB  HB3  sing N N 291 
MET   CG  SD   sing N N 292 
MET   CG  HG2  sing N N 293 
MET   CG  HG3  sing N N 294 
MET   SD  CE   sing N N 295 
MET   CE  HE1  sing N N 296 
MET   CE  HE2  sing N N 297 
MET   CE  HE3  sing N N 298 
MET   OXT HXT  sing N N 299 
PHE   N   CA   sing N N 300 
PHE   N   H    sing N N 301 
PHE   N   H2   sing N N 302 
PHE   CA  C    sing N N 303 
PHE   CA  CB   sing N N 304 
PHE   CA  HA   sing N N 305 
PHE   C   O    doub N N 306 
PHE   C   OXT  sing N N 307 
PHE   CB  CG   sing N N 308 
PHE   CB  HB2  sing N N 309 
PHE   CB  HB3  sing N N 310 
PHE   CG  CD1  doub Y N 311 
PHE   CG  CD2  sing Y N 312 
PHE   CD1 CE1  sing Y N 313 
PHE   CD1 HD1  sing N N 314 
PHE   CD2 CE2  doub Y N 315 
PHE   CD2 HD2  sing N N 316 
PHE   CE1 CZ   doub Y N 317 
PHE   CE1 HE1  sing N N 318 
PHE   CE2 CZ   sing Y N 319 
PHE   CE2 HE2  sing N N 320 
PHE   CZ  HZ   sing N N 321 
PHE   OXT HXT  sing N N 322 
PRO   N   CA   sing N N 323 
PRO   N   CD   sing N N 324 
PRO   N   H    sing N N 325 
PRO   CA  C    sing N N 326 
PRO   CA  CB   sing N N 327 
PRO   CA  HA   sing N N 328 
PRO   C   O    doub N N 329 
PRO   C   OXT  sing N N 330 
PRO   CB  CG   sing N N 331 
PRO   CB  HB2  sing N N 332 
PRO   CB  HB3  sing N N 333 
PRO   CG  CD   sing N N 334 
PRO   CG  HG2  sing N N 335 
PRO   CG  HG3  sing N N 336 
PRO   CD  HD2  sing N N 337 
PRO   CD  HD3  sing N N 338 
PRO   OXT HXT  sing N N 339 
SER   N   CA   sing N N 340 
SER   N   H    sing N N 341 
SER   N   H2   sing N N 342 
SER   CA  C    sing N N 343 
SER   CA  CB   sing N N 344 
SER   CA  HA   sing N N 345 
SER   C   O    doub N N 346 
SER   C   OXT  sing N N 347 
SER   CB  OG   sing N N 348 
SER   CB  HB2  sing N N 349 
SER   CB  HB3  sing N N 350 
SER   OG  HG   sing N N 351 
SER   OXT HXT  sing N N 352 
THR   N   CA   sing N N 353 
THR   N   H    sing N N 354 
THR   N   H2   sing N N 355 
THR   CA  C    sing N N 356 
THR   CA  CB   sing N N 357 
THR   CA  HA   sing N N 358 
THR   C   O    doub N N 359 
THR   C   OXT  sing N N 360 
THR   CB  OG1  sing N N 361 
THR   CB  CG2  sing N N 362 
THR   CB  HB   sing N N 363 
THR   OG1 HG1  sing N N 364 
THR   CG2 HG21 sing N N 365 
THR   CG2 HG22 sing N N 366 
THR   CG2 HG23 sing N N 367 
THR   OXT HXT  sing N N 368 
TRP   N   CA   sing N N 369 
TRP   N   H    sing N N 370 
TRP   N   H2   sing N N 371 
TRP   CA  C    sing N N 372 
TRP   CA  CB   sing N N 373 
TRP   CA  HA   sing N N 374 
TRP   C   O    doub N N 375 
TRP   C   OXT  sing N N 376 
TRP   CB  CG   sing N N 377 
TRP   CB  HB2  sing N N 378 
TRP   CB  HB3  sing N N 379 
TRP   CG  CD1  doub Y N 380 
TRP   CG  CD2  sing Y N 381 
TRP   CD1 NE1  sing Y N 382 
TRP   CD1 HD1  sing N N 383 
TRP   CD2 CE2  doub Y N 384 
TRP   CD2 CE3  sing Y N 385 
TRP   NE1 CE2  sing Y N 386 
TRP   NE1 HE1  sing N N 387 
TRP   CE2 CZ2  sing Y N 388 
TRP   CE3 CZ3  doub Y N 389 
TRP   CE3 HE3  sing N N 390 
TRP   CZ2 CH2  doub Y N 391 
TRP   CZ2 HZ2  sing N N 392 
TRP   CZ3 CH2  sing Y N 393 
TRP   CZ3 HZ3  sing N N 394 
TRP   CH2 HH2  sing N N 395 
TRP   OXT HXT  sing N N 396 
TYR   N   CA   sing N N 397 
TYR   N   H    sing N N 398 
TYR   N   H2   sing N N 399 
TYR   CA  C    sing N N 400 
TYR   CA  CB   sing N N 401 
TYR   CA  HA   sing N N 402 
TYR   C   O    doub N N 403 
TYR   C   OXT  sing N N 404 
TYR   CB  CG   sing N N 405 
TYR   CB  HB2  sing N N 406 
TYR   CB  HB3  sing N N 407 
TYR   CG  CD1  doub Y N 408 
TYR   CG  CD2  sing Y N 409 
TYR   CD1 CE1  sing Y N 410 
TYR   CD1 HD1  sing N N 411 
TYR   CD2 CE2  doub Y N 412 
TYR   CD2 HD2  sing N N 413 
TYR   CE1 CZ   doub Y N 414 
TYR   CE1 HE1  sing N N 415 
TYR   CE2 CZ   sing Y N 416 
TYR   CE2 HE2  sing N N 417 
TYR   CZ  OH   sing N N 418 
TYR   OH  HH   sing N N 419 
TYR   OXT HXT  sing N N 420 
VAL   N   CA   sing N N 421 
VAL   N   H    sing N N 422 
VAL   N   H2   sing N N 423 
VAL   CA  C    sing N N 424 
VAL   CA  CB   sing N N 425 
VAL   CA  HA   sing N N 426 
VAL   C   O    doub N N 427 
VAL   C   OXT  sing N N 428 
VAL   CB  CG1  sing N N 429 
VAL   CB  CG2  sing N N 430 
VAL   CB  HB   sing N N 431 
VAL   CG1 HG11 sing N N 432 
VAL   CG1 HG12 sing N N 433 
VAL   CG1 HG13 sing N N 434 
VAL   CG2 HG21 sing N N 435 
VAL   CG2 HG22 sing N N 436 
VAL   CG2 HG23 sing N N 437 
VAL   OXT HXT  sing N N 438 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   1Q3X 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'C 1 2 1' 
_space_group.name_Hall        'C 2y' 
_space_group.IT_number        5 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9D17 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013920 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.001838 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.024504 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009938 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . VAL   A 1 2   ? -27.05970 -13.84198 -3.14476  1.000 66.20732  ? 364 VAL   A N    1 
ATOM   2    C CA   . VAL   A 1 2   ? -26.14771 -13.66328 -2.01013  1.000 75.64910  ? 364 VAL   A CA   1 
ATOM   3    C C    . VAL   A 1 2   ? -25.01469 -12.69722 -2.35907  1.000 75.73586  ? 364 VAL   A C    1 
ATOM   4    O O    . VAL   A 1 2   ? -24.09396 -13.05971 -3.09647  1.000 69.53003  ? 364 VAL   A O    1 
ATOM   5    C CB   . VAL   A 1 2   ? -25.56606 -15.01130 -1.54946  1.000 76.91414  ? 364 VAL   A CB   1 
ATOM   6    H H    . VAL   A 1 2   ? -26.84796 -14.49232 -3.66780  1.000 79.46084  ? 364 VAL   A H    1 
ATOM   7    H HA   . VAL   A 1 2   ? -26.65549 -13.27873 -1.27856  1.000 90.79098  ? 364 VAL   A HA   1 
ATOM   8    N N    . ASP   A 1 3   ? -25.08374 -11.47948 -1.81048  1.000 69.50235  ? 365 ASP   A N    1 
ATOM   9    C CA   . ASP   A 1 3   ? -24.10117 -10.42349 -2.05758  1.000 74.06395  ? 365 ASP   A CA   1 
ATOM   10   C C    . ASP   A 1 3   ? -23.56979 -9.92963  -0.71271  1.000 82.71525  ? 365 ASP   A C    1 
ATOM   11   O O    . ASP   A 1 3   ? -24.31774 -9.33443  0.07026   1.000 90.65404  ? 365 ASP   A O    1 
ATOM   12   C CB   . ASP   A 1 3   ? -24.73299 -9.28194  -2.86214  1.000 67.20231  ? 365 ASP   A CB   1 
ATOM   13   C CG   . ASP   A 1 3   ? -23.74914 -8.14889  -3.16990  1.000 79.08111  ? 365 ASP   A CG   1 
ATOM   14   O OD1  . ASP   A 1 3   ? -23.36055 -7.41418  -2.24078  1.000 77.35048  ? 365 ASP   A OD1  1 
ATOM   15   O OD2  . ASP   A 1 3   ? -23.36087 -7.98895  -4.34882  1.000 80.00554  ? 365 ASP   A OD2  1 
ATOM   16   H H    . ASP   A 1 3   ? -25.71118 -11.23575 -1.27521  1.000 83.41487  ? 365 ASP   A H    1 
ATOM   17   H HA   . ASP   A 1 3   ? -23.35115 -10.77981 -2.55898  1.000 88.88879  ? 365 ASP   A HA   1 
ATOM   18   H HB2  . ASP   A 1 3   ? -25.05734 -9.63334  -3.70607  1.000 80.65483  ? 365 ASP   A HB2  1 
ATOM   19   H HB3  . ASP   A 1 3   ? -25.46944 -8.90810  -2.35344  1.000 80.65483  ? 365 ASP   A HB3  1 
ATOM   20   N N    . CYS   A 1 4   ? -22.27300 -10.15919 -0.44765  1.000 72.96473  ? 366 CYS   A N    1 
ATOM   21   C CA   . CYS   A 1 4   ? -21.70480 -9.82571  0.85796   1.000 65.23222  ? 366 CYS   A CA   1 
ATOM   22   C C    . CYS   A 1 4   ? -21.43673 -8.33697  1.04358   1.000 65.79746  ? 366 CYS   A C    1 
ATOM   23   O O    . CYS   A 1 4   ? -21.23834 -7.90258  2.18042   1.000 67.99391  ? 366 CYS   A O    1 
ATOM   24   C CB   . CYS   A 1 4   ? -20.40485 -10.58523 1.08586   1.000 61.44251  ? 366 CYS   A CB   1 
ATOM   25   S SG   . CYS   A 1 4   ? -20.59788 -12.35759 1.30190   1.000 66.56839  ? 366 CYS   A SG   1 
ATOM   26   H H    . CYS   A 1 4   ? -21.71306 -10.50264 -1.00273  1.000 87.56973  ? 366 CYS   A H    1 
ATOM   27   H HA   . CYS   A 1 4   ? -22.34656 -10.10158 1.53097   1.000 78.29072  ? 366 CYS   A HA   1 
ATOM   28   H HB2  . CYS   A 1 4   ? -19.82814 -10.44566 0.31851   1.000 73.74306  ? 366 CYS   A HB2  1 
ATOM   29   H HB3  . CYS   A 1 4   ? -19.98160 -10.23782 1.88652   1.000 73.74306  ? 366 CYS   A HB3  1 
ATOM   30   N N    . GLY   A 1 5   ? -21.41840 -7.54771  -0.02656  1.000 68.97364  ? 367 GLY   A N    1 
ATOM   31   C CA   . GLY   A 1 5   ? -21.24977 -6.11971  0.09843   1.000 63.71421  ? 367 GLY   A CA   1 
ATOM   32   C C    . GLY   A 1 5   ? -19.79523 -5.69279  0.18953   1.000 63.12735  ? 367 GLY   A C    1 
ATOM   33   O O    . GLY   A 1 5   ? -18.88090 -6.51908  0.10063   1.000 61.55162  ? 367 GLY   A O    1 
ATOM   34   H H    . GLY   A 1 5   ? -21.50270 -7.82424  -0.83652  1.000 82.78042  ? 367 GLY   A H    1 
ATOM   35   H HA2  . GLY   A 1 5   ? -21.64423 -5.68454  -0.67353  1.000 76.46911  ? 367 GLY   A HA2  1 
ATOM   36   H HA3  . GLY   A 1 5   ? -21.70443 -5.81510  0.89929   1.000 76.46911  ? 367 GLY   A HA3  1 
ATOM   37   N N    . PRO   A 1 6   ? -19.54506 -4.39520  0.36525   1.000 60.89809  ? 368 PRO   A N    1 
ATOM   38   C CA   . PRO   A 1 6   ? -18.15577 -3.90805  0.39057   1.000 62.92948  ? 368 PRO   A CA   1 
ATOM   39   C C    . PRO   A 1 6   ? -17.48549 -4.25496  1.70860   1.000 55.64433  ? 368 PRO   A C    1 
ATOM   40   O O    . PRO   A 1 6   ? -18.09123 -4.10095  2.77720   1.000 54.61597  ? 368 PRO   A O    1 
ATOM   41   C CB   . PRO   A 1 6   ? -18.31110 -2.38319  0.21546   1.000 57.25551  ? 368 PRO   A CB   1 
ATOM   42   C CG   . PRO   A 1 6   ? -19.77176 -2.16604  -0.16712  1.000 53.50497  ? 368 PRO   A CG   1 
ATOM   43   C CD   . PRO   A 1 6   ? -20.49708 -3.28061  0.51255   1.000 55.47122  ? 368 PRO   A CD   1 
ATOM   44   H HA   . PRO   A 1 6   ? -17.64033 -4.27104  -0.34663  1.000 75.52743  ? 368 PRO   A HA   1 
ATOM   45   H HB2  . PRO   A 1 6   ? -18.10164 -1.93377  1.04916   1.000 68.71867  ? 368 PRO   A HB2  1 
ATOM   46   H HB3  . PRO   A 1 6   ? -17.71966 -2.07129  -0.48726  1.000 68.71867  ? 368 PRO   A HB3  1 
ATOM   47   H HG2  . PRO   A 1 6   ? -20.07649 -1.30309  0.15438   1.000 64.21801  ? 368 PRO   A HG2  1 
ATOM   48   H HG3  . PRO   A 1 6   ? -19.87590 -2.21694  -1.13017  1.000 64.21801  ? 368 PRO   A HG3  1 
ATOM   49   H HD2  . PRO   A 1 6   ? -20.65648 -3.07674  1.44739   1.000 66.57752  ? 368 PRO   A HD2  1 
ATOM   50   H HD3  . PRO   A 1 6   ? -21.33673 -3.47543  0.06764   1.000 66.57752  ? 368 PRO   A HD3  1 
ATOM   51   N N    . PRO   A 1 7   ? -16.24292 -4.73027  1.69985   1.000 60.59737  ? 369 PRO   A N    1 
ATOM   52   C CA   . PRO   A 1 7   ? -15.63845 -5.17767  2.95975   1.000 59.67995  ? 369 PRO   A CA   1 
ATOM   53   C C    . PRO   A 1 7   ? -15.19211 -4.02466  3.84289   1.000 57.79330  ? 369 PRO   A C    1 
ATOM   54   O O    . PRO   A 1 7   ? -14.94911 -2.89911  3.39849   1.000 60.84803  ? 369 PRO   A O    1 
ATOM   55   C CB   . PRO   A 1 7   ? -14.43608 -6.01563  2.51236   1.000 49.17689  ? 369 PRO   A CB   1 
ATOM   56   C CG   . PRO   A 1 7   ? -14.05702 -5.46628  1.21325   1.000 51.32127  ? 369 PRO   A CG   1 
ATOM   57   C CD   . PRO   A 1 7   ? -15.31979 -4.93621  0.56295   1.000 56.18218  ? 369 PRO   A CD   1 
ATOM   58   H HA   . PRO   A 1 7   ? -16.26611 -5.73288  3.44830   1.000 71.62800  ? 369 PRO   A HA   1 
ATOM   59   H HB2  . PRO   A 1 7   ? -13.71308 -5.92421  3.15252   1.000 59.02433  ? 369 PRO   A HB2  1 
ATOM   60   H HB3  . PRO   A 1 7   ? -14.69369 -6.94748  2.43368   1.000 59.02433  ? 369 PRO   A HB3  1 
ATOM   61   H HG2  . PRO   A 1 7   ? -13.41629 -4.74949  1.34204   1.000 61.59757  ? 369 PRO   A HG2  1 
ATOM   62   H HG3  . PRO   A 1 7   ? -13.66533 -6.16769  0.66966   1.000 61.59757  ? 369 PRO   A HG3  1 
ATOM   63   H HD2  . PRO   A 1 7   ? -15.14511 -4.09832  0.10653   1.000 67.43067  ? 369 PRO   A HD2  1 
ATOM   64   H HD3  . PRO   A 1 7   ? -15.68272 -5.58438  -0.06080  1.000 67.43067  ? 369 PRO   A HD3  1 
ATOM   65   N N    . ASP   A 1 8   ? -15.10100 -4.33302  5.12939   1.000 59.64750  ? 370 ASP   A N    1 
ATOM   66   C CA   . ASP   A 1 8   ? -14.59961 -3.36852  6.09327   1.000 62.59880  ? 370 ASP   A CA   1 
ATOM   67   C C    . ASP   A 1 8   ? -13.12091 -3.08920  5.84226   1.000 58.79812  ? 370 ASP   A C    1 
ATOM   68   O O    . ASP   A 1 8   ? -12.35936 -3.96603  5.41889   1.000 50.95204  ? 370 ASP   A O    1 
ATOM   69   C CB   . ASP   A 1 8   ? -14.79327 -3.89370  7.51524   1.000 55.64608  ? 370 ASP   A CB   1 
ATOM   70   C CG   . ASP   A 1 8   ? -16.16231 -3.55062  8.08828   1.000 68.94109  ? 370 ASP   A CG   1 
ATOM   71   O OD1  . ASP   A 1 8   ? -16.53591 -4.09492  9.15551   1.000 64.03905  ? 370 ASP   A OD1  1 
ATOM   72   O OD2  . ASP   A 1 8   ? -16.86747 -2.72567  7.47490   1.000 95.04885  ? 370 ASP   A OD2  1 
ATOM   73   H H    . ASP   A 1 8   ? -15.32256 -5.09188  5.46796   1.000 71.58905  ? 370 ASP   A H    1 
ATOM   74   H HA   . ASP   A 1 8   ? -15.08923 -2.53555  6.00763   1.000 75.13062  ? 370 ASP   A HA   1 
ATOM   75   H HB2  . ASP   A 1 8   ? -14.70345 -4.85952  7.51054   1.000 66.78735  ? 370 ASP   A HB2  1 
ATOM   76   H HB3  . ASP   A 1 8   ? -14.11958 -3.50066  8.09192   1.000 66.78735  ? 370 ASP   A HB3  1 
ATOM   77   N N    . ASP   A 1 9   ? -12.72594 -1.84752  6.09320   1.000 54.78308  ? 371 ASP   A N    1 
ATOM   78   C CA   . ASP   A 1 9   ? -11.32442 -1.46191  6.00710   1.000 65.16709  ? 371 ASP   A CA   1 
ATOM   79   C C    . ASP   A 1 9   ? -10.54696 -2.09421  7.16272   1.000 61.05290  ? 371 ASP   A C    1 
ATOM   80   O O    . ASP   A 1 9   ? -11.09955 -2.37319  8.23218   1.000 53.11221  ? 371 ASP   A O    1 
ATOM   81   C CB   . ASP   A 1 9   ? -11.22059 0.07213   6.00970   1.000 66.29060  ? 371 ASP   A CB   1 
ATOM   82   C CG   . ASP   A 1 9   ? -9.87389  0.58845   6.49461   1.000 76.41753  ? 371 ASP   A CG   1 
ATOM   83   O OD1  . ASP   A 1 9   ? -8.87840  0.46743   5.74858   1.000 71.84981  ? 371 ASP   A OD1  1 
ATOM   84   O OD2  . ASP   A 1 9   ? -9.81310  1.12690   7.62006   1.000 91.90780  ? 371 ASP   A OD2  1 
ATOM   85   H H    . ASP   A 1 9   ? -13.25253 -1.20539  6.31673   1.000 65.75175  ? 371 ASP   A H    1 
ATOM   86   H HA   . ASP   A 1 9   ? -10.91635 -1.77423  5.18440   1.000 78.21256  ? 371 ASP   A HA   1 
ATOM   87   H HB2  . ASP   A 1 9   ? -11.35473 0.39667   5.10549   1.000 79.56078  ? 371 ASP   A HB2  1 
ATOM   88   H HB3  . ASP   A 1 9   ? -11.90474 0.43138   6.59603   1.000 79.56078  ? 371 ASP   A HB3  1 
ATOM   89   N N    . LEU   A 1 10  ? -9.26081  -2.36538  6.92545   1.000 56.80367  ? 372 LEU   A N    1 
ATOM   90   C CA   . LEU   A 1 10  ? -8.39611  -2.96526  7.93816   1.000 57.19942  ? 372 LEU   A CA   1 
ATOM   91   C C    . LEU   A 1 10  ? -7.46023  -1.90497  8.49203   1.000 49.62667  ? 372 LEU   A C    1 
ATOM   92   O O    . LEU   A 1 10  ? -6.64804  -1.37899  7.72187   1.000 48.39504  ? 372 LEU   A O    1 
ATOM   93   C CB   . LEU   A 1 10  ? -7.59019  -4.11445  7.34057   1.000 50.54339  ? 372 LEU   A CB   1 
ATOM   94   C CG   . LEU   A 1 10  ? -6.64595  -4.86290  8.28091   1.000 51.45038  ? 372 LEU   A CG   1 
ATOM   95   C CD1  . LEU   A 1 10  ? -7.40278  -5.52075  9.41170   1.000 49.14941  ? 372 LEU   A CD1  1 
ATOM   96   C CD2  . LEU   A 1 10  ? -5.85998  -5.87614  7.49747   1.000 44.06032  ? 372 LEU   A CD2  1 
ATOM   97   H H    . LEU   A 1 10  ? -8.86477  -2.20877  6.17831   1.000 68.17646  ? 372 LEU   A H    1 
ATOM   98   H HA   . LEU   A 1 10  ? -8.94114  -3.31254  8.66151   1.000 68.65135  ? 372 LEU   A HA   1 
ATOM   99   H HB2  . LEU   A 1 10  ? -8.21618  -4.76722  6.98993   1.000 60.66412  ? 372 LEU   A HB2  1 
ATOM   100  H HB3  . LEU   A 1 10  ? -7.04725  -3.75574  6.62123   1.000 60.66412  ? 372 LEU   A HB3  1 
ATOM   101  H HG   . LEU   A 1 10  ? -6.02923  -4.23283  8.68536   1.000 61.75251  ? 372 LEU   A HG   1 
ATOM   102  H HD11 . LEU   A 1 10  ? -6.81140  -6.13755  9.87076   1.000 58.99135  ? 372 LEU   A HD11 1 
ATOM   103  H HD12 . LEU   A 1 10  ? -7.70907  -4.83628  10.02699  1.000 58.99135  ? 372 LEU   A HD12 1 
ATOM   104  H HD13 . LEU   A 1 10  ? -8.16228  -6.00080  9.04618   1.000 58.99135  ? 372 LEU   A HD13 1 
ATOM   105  H HD21 . LEU   A 1 10  ? -5.30923  -6.38991  8.10871   1.000 52.88444  ? 372 LEU   A HD21 1 
ATOM   106  H HD22 . LEU   A 1 10  ? -6.47649  -6.46419  7.03377   1.000 52.88444  ? 372 LEU   A HD22 1 
ATOM   107  H HD23 . LEU   A 1 10  ? -5.29871  -5.41313  6.85599   1.000 52.88444  ? 372 LEU   A HD23 1 
ATOM   108  N N    . PRO   A 1 11  ? -7.50546  -1.55672  9.78268   1.000 46.80133  ? 373 PRO   A N    1 
ATOM   109  C CA   . PRO   A 1 11  ? -6.54151  -0.57045  10.29999  1.000 51.14016  ? 373 PRO   A CA   1 
ATOM   110  C C    . PRO   A 1 11  ? -5.10515  -1.05763  10.15994  1.000 46.65644  ? 373 PRO   A C    1 
ATOM   111  O O    . PRO   A 1 11  ? -4.81044  -2.23987  10.33554  1.000 47.38637  ? 373 PRO   A O    1 
ATOM   112  C CB   . PRO   A 1 11  ? -6.94569  -0.40968  11.76963  1.000 45.59165  ? 373 PRO   A CB   1 
ATOM   113  C CG   . PRO   A 1 11  ? -8.40303  -0.78823  11.79872  1.000 45.75440  ? 373 PRO   A CG   1 
ATOM   114  C CD   . PRO   A 1 11  ? -8.53556  -1.89030  10.78946  1.000 42.58260  ? 373 PRO   A CD   1 
ATOM   115  H HA   . PRO   A 1 11  ? -6.64163  0.27653   9.83793   1.000 61.38025  ? 373 PRO   A HA   1 
ATOM   116  H HB2  . PRO   A 1 11  ? -6.41894  -1.00395  12.32667  1.000 54.72203  ? 373 PRO   A HB2  1 
ATOM   117  H HB3  . PRO   A 1 11  ? -6.81757  0.50958   12.05147  1.000 54.72203  ? 373 PRO   A HB3  1 
ATOM   118  H HG2  . PRO   A 1 11  ? -8.64693  -1.09809  12.68494  1.000 54.91734  ? 373 PRO   A HG2  1 
ATOM   119  H HG3  . PRO   A 1 11  ? -8.94833  -0.02474  11.55247  1.000 54.91734  ? 373 PRO   A HG3  1 
ATOM   120  H HD2  . PRO   A 1 11  ? -8.35528  -2.75290  11.19482  1.000 51.11117  ? 373 PRO   A HD2  1 
ATOM   121  H HD3  . PRO   A 1 11  ? -9.42015  -1.88914  10.39147  1.000 51.11117  ? 373 PRO   A HD3  1 
ATOM   122  N N    . SER   A 1 12  ? -4.22070  -0.13481  9.77939   1.000 46.50775  ? 374 SER   A N    1 
ATOM   123  C CA   . SER   A 1 12  ? -2.82001  -0.42185  9.46788   1.000 50.86194  ? 374 SER   A CA   1 
ATOM   124  C C    . SER   A 1 12  ? -2.67948  -1.46584  8.36635   1.000 52.19595  ? 374 SER   A C    1 
ATOM   125  O O    . SER   A 1 12  ? -1.65001  -2.14734  8.27887   1.000 54.86132  ? 374 SER   A O    1 
ATOM   126  C CB   . SER   A 1 12  ? -2.04768  -0.86710  10.72077  1.000 46.99129  ? 374 SER   A CB   1 
ATOM   127  O OG   . SER   A 1 12  ? -2.22767  0.07289   11.76292  1.000 48.53570  ? 374 SER   A OG   1 
ATOM   128  H H    . SER   A 1 12  ? -4.41676  0.69787   9.69101   1.000 55.82136  ? 374 SER   A H    1 
ATOM   129  H HA   . SER   A 1 12  ? -2.41169  0.39658   9.14484   1.000 61.04638  ? 374 SER   A HA   1 
ATOM   130  H HB2  . SER   A 1 12  ? -2.38044  -1.73112  11.00996  1.000 56.40160  ? 374 SER   A HB2  1 
ATOM   131  H HB3  . SER   A 1 12  ? -1.10346  -0.92964  10.50760  1.000 56.40160  ? 374 SER   A HB3  1 
ATOM   132  H HG   . SER   A 1 12  ? -1.78761  -0.16033  12.43935  1.000 58.25489  ? 374 SER   A HG   1 
ATOM   133  N N    . GLY   A 1 13  ? -3.70511  -1.60638  7.52862   1.000 50.50663  ? 375 GLY   A N    1 
ATOM   134  C CA   . GLY   A 1 13  ? -3.67430  -2.54693  6.43099   1.000 52.40856  ? 375 GLY   A CA   1 
ATOM   135  C C    . GLY   A 1 13  ? -4.62552  -2.09634  5.34579   1.000 52.48457  ? 375 GLY   A C    1 
ATOM   136  O O    . GLY   A 1 13  ? -5.27785  -1.05389  5.44909   1.000 55.68686  ? 375 GLY   A O    1 
ATOM   137  H H    . GLY   A 1 13  ? -4.43766  -1.15895  7.58130   1.000 60.62001  ? 375 GLY   A H    1 
ATOM   138  H HA2  . GLY   A 1 13  ? -2.77788  -2.59956  6.06416   1.000 62.90233  ? 375 GLY   A HA2  1 
ATOM   139  H HA3  . GLY   A 1 13  ? -3.94109  -3.42673  6.74031   1.000 62.90233  ? 375 GLY   A HA3  1 
ATOM   140  N N    . ARG   A 1 14  ? -4.69182  -2.90900  4.29628   1.000 47.71567  ? 376 ARG   A N    1 
ATOM   141  C CA   . ARG   A 1 14  ? -5.50454  -2.62500  3.12502   1.000 51.82575  ? 376 ARG   A CA   1 
ATOM   142  C C    . ARG   A 1 14  ? -6.31274  -3.86211  2.75961   1.000 52.18125  ? 376 ARG   A C    1 
ATOM   143  O O    . ARG   A 1 14  ? -6.02268  -4.97301  3.21837   1.000 41.60305  ? 376 ARG   A O    1 
ATOM   144  C CB   . ARG   A 1 14  ? -4.62755  -2.19408  1.94391   1.000 50.65677  ? 376 ARG   A CB   1 
ATOM   145  C CG   . ARG   A 1 14  ? -3.76508  -3.31207  1.39788   1.000 52.18580  ? 376 ARG   A CG   1 
ATOM   146  C CD   . ARG   A 1 14  ? -2.67173  -2.81954  0.46732   1.000 62.24779  ? 376 ARG   A CD   1 
ATOM   147  N NE   . ARG   A 1 14  ? -1.71205  -1.92720  1.10824   1.000 66.56806  ? 376 ARG   A NE   1 
ATOM   148  C CZ   . ARG   A 1 14  ? -0.62385  -2.31239  1.76665   1.000 68.10786  ? 376 ARG   A CZ   1 
ATOM   149  N NH1  . ARG   A 1 14  ? -0.33852  -3.59641  1.95758   1.000 58.77076  ? 376 ARG   A NH1  1 
ATOM   150  N NH2  . ARG   A 1 14  ? 0.20463   -1.38352  2.24510   1.000 60.64302  ? 376 ARG   A NH2  1 
ATOM   151  H H    . ARG   A 1 14  ? -4.26177  -3.65162  4.24003   1.000 57.27086  ? 376 ARG   A H    1 
ATOM   152  H HA   . ARG   A 1 14  ? -6.12931  -1.90896  3.31957   1.000 62.20296  ? 376 ARG   A HA   1 
ATOM   153  H HB2  . ARG   A 1 14  ? -5.20016  -1.88176  1.22594   1.000 60.80018  ? 376 ARG   A HB2  1 
ATOM   154  H HB3  . ARG   A 1 14  ? -4.03983  -1.47916  2.23439   1.000 60.80018  ? 376 ARG   A HB3  1 
ATOM   155  H HG2  . ARG   A 1 14  ? -3.34104  -3.77350  2.13826   1.000 62.63501  ? 376 ARG   A HG2  1 
ATOM   156  H HG3  . ARG   A 1 14  ? -4.32521  -3.92803  0.90014   1.000 62.63501  ? 376 ARG   A HG3  1 
ATOM   157  H HD2  . ARG   A 1 14  ? -2.18225  -3.58502  0.12770   1.000 74.70940  ? 376 ARG   A HD2  1 
ATOM   158  H HD3  . ARG   A 1 14  ? -3.08098  -2.33517  -0.26671  1.000 74.70940  ? 376 ARG   A HD3  1 
ATOM   159  H HE   . ARG   A 1 14  ? -1.86294  -1.08218  1.05567   1.000 79.89372  ? 376 ARG   A HE   1 
ATOM   160  H HH11 . ARG   A 1 14  ? -0.86466  -4.20395  1.65151   1.000 70.53696  ? 376 ARG   A HH11 1 
ATOM   161  H HH12 . ARG   A 1 14  ? 0.37225   -3.81969  2.38719   1.000 70.53696  ? 376 ARG   A HH12 1 
ATOM   162  H HH21 . ARG   A 1 14  ? 0.03094   -0.54977  2.12559   1.000 72.78368  ? 376 ARG   A HH21 1 
ATOM   163  H HH22 . ARG   A 1 14  ? 0.91263   -1.61821  2.67318   1.000 72.78368  ? 376 ARG   A HH22 1 
ATOM   164  N N    . VAL   A 1 15  ? -7.34989  -3.64506  1.94154   1.000 45.92044  ? 377 VAL   A N    1 
ATOM   165  C CA   . VAL   A 1 15  ? -8.13229  -4.72038  1.34579   1.000 46.49780  ? 377 VAL   A CA   1 
ATOM   166  C C    . VAL   A 1 15  ? -8.03165  -4.59449  -0.16823  1.000 52.13043  ? 377 VAL   A C    1 
ATOM   167  O O    . VAL   A 1 15  ? -7.86014  -3.49822  -0.71257  1.000 48.01249  ? 377 VAL   A O    1 
ATOM   168  C CB   . VAL   A 1 15  ? -9.60965  -4.71327  1.81232   1.000 50.62796  ? 377 VAL   A CB   1 
ATOM   169  C CG1  . VAL   A 1 15  ? -10.45930 -3.62630  1.08828   1.000 45.16458  ? 377 VAL   A CG1  1 
ATOM   170  C CG2  . VAL   A 1 15  ? -10.23155 -6.09511  1.62406   1.000 49.64394  ? 377 VAL   A CG2  1 
ATOM   171  H H    . VAL   A 1 15  ? -7.62181  -2.86139  1.71453   1.000 55.11658  ? 377 VAL   A H    1 
ATOM   172  H HA   . VAL   A 1 15  ? -7.75515  -5.57370  1.61132   1.000 55.80941  ? 377 VAL   A HA   1 
ATOM   173  H HB   . VAL   A 1 15  ? -9.61759  -4.48886  2.75597   1.000 60.76560  ? 377 VAL   A HB   1 
ATOM   174  H HG11 . VAL   A 1 15  ? -11.33110 -3.57395  1.51032   1.000 54.20955  ? 377 VAL   A HG11 1 
ATOM   175  H HG12 . VAL   A 1 15  ? -10.00566 -2.77184  1.15913   1.000 54.20955  ? 377 VAL   A HG12 1 
ATOM   176  H HG13 . VAL   A 1 15  ? -10.55776 -3.87216  0.15514   1.000 54.20955  ? 377 VAL   A HG13 1 
ATOM   177  H HG21 . VAL   A 1 15  ? -11.15602 -6.06787  1.91650   1.000 59.58479  ? 377 VAL   A HG21 1 
ATOM   178  H HG22 . VAL   A 1 15  ? -10.18852 -6.33555  0.68532   1.000 59.58479  ? 377 VAL   A HG22 1 
ATOM   179  H HG23 . VAL   A 1 15  ? -9.73597  -6.73926  2.15355   1.000 59.58479  ? 377 VAL   A HG23 1 
ATOM   180  N N    . GLU   A 1 16  ? -8.14651  -5.73248  -0.84223  1.000 43.37531  ? 378 GLU   A N    1 
ATOM   181  C CA   . GLU   A 1 16  ? -8.07114  -5.79355  -2.29255  1.000 54.52685  ? 378 GLU   A CA   1 
ATOM   182  C C    . GLU   A 1 16  ? -9.07232  -6.82319  -2.80002  1.000 50.66605  ? 378 GLU   A C    1 
ATOM   183  O O    . GLU   A 1 16  ? -9.28016  -7.86476  -2.16957  1.000 36.13474  ? 378 GLU   A O    1 
ATOM   184  C CB   . GLU   A 1 16  ? -6.65677  -6.15890  -2.76541  1.000 57.82851  ? 378 GLU   A CB   1 
ATOM   185  C CG   . GLU   A 1 16  ? -5.67669  -4.97514  -2.76227  1.000 73.91219  ? 378 GLU   A CG   1 
ATOM   186  C CD   . GLU   A 1 16  ? -4.23962  -5.33028  -2.34068  1.000 77.06582  ? 378 GLU   A CD   1 
ATOM   187  O OE1  . GLU   A 1 16  ? -3.85449  -6.52820  -2.33164  1.000 68.82904  ? 378 GLU   A OE1  1 
ATOM   188  O OE2  . GLU   A 1 16  ? -3.48638  -4.38530  -2.03330  1.000 65.89397  ? 378 GLU   A OE2  1 
ATOM   189  H H    . GLU   A 1 16  ? -8.27133  -6.49861  -0.47202  1.000 52.06242  ? 378 GLU   A H    1 
ATOM   190  H HA   . GLU   A 1 16  ? -8.30207  -4.93017  -2.66957  1.000 65.44428  ? 378 GLU   A HA   1 
ATOM   191  H HB2  . GLU   A 1 16  ? -6.29813  -6.84164  -2.17706  1.000 69.40626  ? 378 GLU   A HB2  1 
ATOM   192  H HB3  . GLU   A 1 16  ? -6.70930  -6.49724  -3.67297  1.000 69.40626  ? 378 GLU   A HB3  1 
ATOM   193  H HG2  . GLU   A 1 16  ? -5.63495  -4.60681  -3.65864  1.000 88.70669  ? 378 GLU   A HG2  1 
ATOM   194  H HG3  . GLU   A 1 16  ? -6.00489  -4.30455  -2.14300  1.000 88.70669  ? 378 GLU   A HG3  1 
ATOM   195  N N    . TYR   A 1 17  ? -9.69963  -6.51198  -3.93204  1.000 54.83462  ? 379 TYR   A N    1 
ATOM   196  C CA   . TYR   A 1 17  ? -10.58519 -7.45413  -4.60620  1.000 44.81949  ? 379 TYR   A CA   1 
ATOM   197  C C    . TYR   A 1 17  ? -9.76439  -8.37012  -5.50003  1.000 44.82807  ? 379 TYR   A C    1 
ATOM   198  O O    . TYR   A 1 17  ? -9.04715  -7.89843  -6.38638  1.000 50.27079  ? 379 TYR   A O    1 
ATOM   199  C CB   . TYR   A 1 17  ? -11.62295 -6.70902  -5.44143  1.000 50.56072  ? 379 TYR   A CB   1 
ATOM   200  C CG   . TYR   A 1 17  ? -12.52705 -5.78780  -4.65294  1.000 51.98957  ? 379 TYR   A CG   1 
ATOM   201  C CD1  . TYR   A 1 17  ? -12.17248 -4.47186  -4.43496  1.000 46.93347  ? 379 TYR   A CD1  1 
ATOM   202  C CD2  . TYR   A 1 17  ? -13.73368 -6.23449  -4.13252  1.000 49.58402  ? 379 TYR   A CD2  1 
ATOM   203  C CE1  . TYR   A 1 17  ? -12.97412 -3.62617  -3.72286  1.000 53.12175  ? 379 TYR   A CE1  1 
ATOM   204  C CE2  . TYR   A 1 17  ? -14.56460 -5.37309  -3.41550  1.000 47.85573  ? 379 TYR   A CE2  1 
ATOM   205  C CZ   . TYR   A 1 17  ? -14.16803 -4.07579  -3.21231  1.000 54.70020  ? 379 TYR   A CZ   1 
ATOM   206  O OH   . TYR   A 1 17  ? -14.96242 -3.19673  -2.49991  1.000 67.26351  ? 379 TYR   A OH   1 
ATOM   207  H H    . TYR   A 1 17  ? -9.62747  -5.75432  -4.33246  1.000 65.81360  ? 379 TYR   A H    1 
ATOM   208  H HA   . TYR   A 1 17  ? -11.04609 -7.98791  -3.94020  1.000 53.79545  ? 379 TYR   A HA   1 
ATOM   209  H HB2  . TYR   A 1 17  ? -11.15840 -6.16890  -6.09973  1.000 60.68492  ? 379 TYR   A HB2  1 
ATOM   210  H HB3  . TYR   A 1 17  ? -12.18682 -7.36136  -5.88573  1.000 60.68492  ? 379 TYR   A HB3  1 
ATOM   211  H HD1  . TYR   A 1 17  ? -11.36978 -4.15401  -4.78072  1.000 56.33221  ? 379 TYR   A HD1  1 
ATOM   212  H HD2  . TYR   A 1 17  ? -13.99138 -7.11845  -4.26330  1.000 59.51287  ? 379 TYR   A HD2  1 
ATOM   213  H HE1  . TYR   A 1 17  ? -12.71173 -2.74494  -3.58329  1.000 63.75816  ? 379 TYR   A HE1  1 
ATOM   214  H HE2  . TYR   A 1 17  ? -15.37753 -5.67483  -3.07936  1.000 57.43893  ? 379 TYR   A HE2  1 
ATOM   215  H HH   . TYR   A 1 17  ? -15.67674 -3.57528  -2.27179  1.000 80.72827  ? 379 TYR   A HH   1 
ATOM   216  N N    . ILE   A 1 18  ? -9.87977  -9.67343  -5.27947  1.000 47.49741  ? 380 ILE   A N    1 
ATOM   217  C CA   . ILE   A 1 18  ? -9.20639  -10.66006 -6.11539  1.000 49.53313  ? 380 ILE   A CA   1 
ATOM   218  C C    . ILE   A 1 18  ? -10.04246 -10.99942 -7.34693  1.000 51.37507  ? 380 ILE   A C    1 
ATOM   219  O O    . ILE   A 1 18  ? -9.55833  -10.90093 -8.47643  1.000 44.71452  ? 380 ILE   A O    1 
ATOM   220  C CB   . ILE   A 1 18  ? -8.88005  -11.91699 -5.27707  1.000 51.41054  ? 380 ILE   A CB   1 
ATOM   221  C CG1  . ILE   A 1 18  ? -8.05826  -11.53986 -4.02537  1.000 55.03098  ? 380 ILE   A CG1  1 
ATOM   222  C CG2  . ILE   A 1 18  ? -8.13315  -12.97443 -6.11120  1.000 60.08621  ? 380 ILE   A CG2  1 
ATOM   223  C CD1  . ILE   A 1 18  ? -6.70255  -10.86164 -4.30567  1.000 51.14035  ? 380 ILE   A CD1  1 
ATOM   224  H H    . ILE   A 1 18  ? -10.34755 -10.01680 -4.64474  1.000 57.00895  ? 380 ILE   A H    1 
ATOM   225  H HA   . ILE   A 1 18  ? -8.36708  -10.28738 -6.42775  1.000 59.45182  ? 380 ILE   A HA   1 
ATOM   226  H HB   . ILE   A 1 18  ? -9.72369  -12.30162 -4.99205  1.000 61.70471  ? 380 ILE   A HB   1 
ATOM   227  H HG12 . ILE   A 1 18  ? -8.58332  -10.92586 -3.48852  1.000 66.04923  ? 380 ILE   A HG12 1 
ATOM   228  H HG13 . ILE   A 1 18  ? -7.87812  -12.34957 -3.52255  1.000 66.04923  ? 380 ILE   A HG13 1 
ATOM   229  H HG21 . ILE   A 1 18  ? -7.86950  -13.70576 -5.53108  1.000 72.11550  ? 380 ILE   A HG21 1 
ATOM   230  H HG22 . ILE   A 1 18  ? -8.72324  -13.30134 -6.80822  1.000 72.11550  ? 380 ILE   A HG22 1 
ATOM   231  H HG23 . ILE   A 1 18  ? -7.34725  -12.56670 -6.50745  1.000 72.11550  ? 380 ILE   A HG23 1 
ATOM   232  H HD11 . ILE   A 1 18  ? -6.24480  -10.71091 -3.46386  1.000 61.38048  ? 380 ILE   A HD11 1 
ATOM   233  H HD12 . ILE   A 1 18  ? -6.17037  -11.44182 -4.87232  1.000 61.38048  ? 380 ILE   A HD12 1 
ATOM   234  H HD13 . ILE   A 1 18  ? -6.85931  -10.01540 -4.75311  1.000 61.38048  ? 380 ILE   A HD13 1 
ATOM   235  N N    . THR   A 1 19  ? -11.30675 -11.39688 -7.15238  1.000 54.53902  ? 381 THR   A N    1 
ATOM   236  C CA   . THR   A 1 19  ? -12.13656 -11.82356 -8.27958  1.000 49.34730  ? 381 THR   A CA   1 
ATOM   237  C C    . THR   A 1 19  ? -12.34445 -10.68498 -9.27304  1.000 43.84227  ? 381 THR   A C    1 
ATOM   238  O O    . THR   A 1 19  ? -12.08388 -10.84620 -10.47022 1.000 40.80014  ? 381 THR   A O    1 
ATOM   239  C CB   . THR   A 1 19  ? -13.47577 -12.36070 -7.77273  1.000 54.87202  ? 381 THR   A CB   1 
ATOM   240  O OG1  . THR   A 1 19  ? -13.25477 -13.14679 -6.59839  1.000 51.08262  ? 381 THR   A OG1  1 
ATOM   241  C CG2  . THR   A 1 19  ? -14.15092 -13.24048 -8.83128  1.000 61.34367  ? 381 THR   A CG2  1 
ATOM   242  H H    . THR   A 1 19  ? -11.70010 -11.42758 -6.38822  1.000 65.45888  ? 381 THR   A H    1 
ATOM   243  H HA   . THR   A 1 19  ? -11.68455 -12.54455 -8.74515  1.000 59.22881  ? 381 THR   A HA   1 
ATOM   244  H HB   . THR   A 1 19  ? -14.06299 -11.61482 -7.57337  1.000 65.85848  ? 381 THR   A HB   1 
ATOM   245  H HG1  . THR   A 1 19  ? -13.96771 -13.52709 -6.36886  1.000 61.31120  ? 381 THR   A HG1  1 
ATOM   246  H HG21 . THR   A 1 19  ? -14.99865 -13.57170 -8.49579  1.000 73.62446  ? 381 THR   A HG21 1 
ATOM   247  H HG22 . THR   A 1 19  ? -14.31100 -12.72558 -9.63760  1.000 73.62446  ? 381 THR   A HG22 1 
ATOM   248  H HG23 . THR   A 1 19  ? -13.58142 -13.99530 -9.04765  1.000 73.62446  ? 381 THR   A HG23 1 
ATOM   249  N N    . GLY   A 1 20  ? -12.79823 -9.52146  -8.79923  1.000 39.09207  ? 382 GLY   A N    1 
ATOM   250  C CA   . GLY   A 1 20  ? -12.77662 -8.32413  -9.61020  1.000 34.86358  ? 382 GLY   A CA   1 
ATOM   251  C C    . GLY   A 1 20  ? -13.08504 -7.06300  -8.82409  1.000 40.62713  ? 382 GLY   A C    1 
ATOM   252  O O    . GLY   A 1 20  ? -13.62848 -7.12213  -7.71737  1.000 42.77711  ? 382 GLY   A O    1 
ATOM   253  H H    . GLY   A 1 20  ? -13.12158 -9.40961  -8.01023  1.000 46.92254  ? 382 GLY   A H    1 
ATOM   254  H HA2  . GLY   A 1 20  ? -11.89717 -8.22503  -10.00723 1.000 41.84835  ? 382 GLY   A HA2  1 
ATOM   255  H HA3  . GLY   A 1 20  ? -13.43494 -8.40757  -10.31771 1.000 41.84835  ? 382 GLY   A HA3  1 
ATOM   256  N N    . PRO   A 1 21  ? -12.75414 -5.88379  -9.37727  1.000 42.89945  ? 383 PRO   A N    1 
ATOM   257  C CA   . PRO   A 1 21  ? -13.08779 -4.63482  -8.67227  1.000 51.21904  ? 383 PRO   A CA   1 
ATOM   258  C C    . PRO   A 1 21  ? -14.56562 -4.52040  -8.32489  1.000 58.62845  ? 383 PRO   A C    1 
ATOM   259  O O    . PRO   A 1 21  ? -15.40645 -4.35146  -9.21179  1.000 83.18532  ? 383 PRO   A O    1 
ATOM   260  C CB   . PRO   A 1 21  ? -12.66274 -3.54780  -9.66717  1.000 43.90664  ? 383 PRO   A CB   1 
ATOM   261  C CG   . PRO   A 1 21  ? -11.58534 -4.15836  -10.44368 1.000 47.22123  ? 383 PRO   A CG   1 
ATOM   262  C CD   . PRO   A 1 21  ? -11.94927 -5.61769  -10.58512 1.000 43.50387  ? 383 PRO   A CD   1 
ATOM   263  H HA   . PRO   A 1 21  ? -12.56316 -4.56210  -7.85964  1.000 61.47490  ? 383 PRO   A HA   1 
ATOM   264  H HB2  . PRO   A 1 21  ? -13.41062 -3.30893  -10.23682 1.000 52.70002  ? 383 PRO   A HB2  1 
ATOM   265  H HB3  . PRO   A 1 21  ? -12.34709 -2.76537  -9.18856  1.000 52.70002  ? 383 PRO   A HB3  1 
ATOM   266  H HG2  . PRO   A 1 21  ? -11.52841 -3.73319  -11.31368 1.000 56.67753  ? 383 PRO   A HG2  1 
ATOM   267  H HG3  . PRO   A 1 21  ? -10.74465 -4.05886  -9.97015  1.000 56.67753  ? 383 PRO   A HG3  1 
ATOM   268  H HD2  . PRO   A 1 21  ? -12.47204 -5.76707  -11.38843 1.000 52.21669  ? 383 PRO   A HD2  1 
ATOM   269  H HD3  . PRO   A 1 21  ? -11.15362 -6.17236  -10.59916 1.000 52.21669  ? 383 PRO   A HD3  1 
ATOM   270  N N    . GLY   A 1 22  ? -14.89384 -4.64668  -7.03633  1.000 55.97702  ? 384 GLY   A N    1 
ATOM   271  C CA   . GLY   A 1 22  ? -16.26629 -4.56526  -6.57619  1.000 53.86353  ? 384 GLY   A CA   1 
ATOM   272  C C    . GLY   A 1 22  ? -17.02543 -5.88200  -6.52774  1.000 51.81150  ? 384 GLY   A C    1 
ATOM   273  O O    . GLY   A 1 22  ? -18.14162 -5.91120  -5.99616  1.000 52.50448  ? 384 GLY   A O    1 
ATOM   274  H H    . GLY   A 1 22  ? -14.32493 -4.78200  -6.40575  1.000 67.18448  ? 384 GLY   A H    1 
ATOM   275  H HA2  . GLY   A 1 22  ? -16.26828 -4.19384  -5.68011  1.000 64.64829  ? 384 GLY   A HA2  1 
ATOM   276  H HA3  . GLY   A 1 22  ? -16.75320 -3.96894  -7.16629  1.000 64.64829  ? 384 GLY   A HA3  1 
ATOM   277  N N    . VAL   A 1 23  ? -16.46338 -6.97204  -7.05139  1.000 50.82844  ? 385 VAL   A N    1 
ATOM   278  C CA   . VAL   A 1 23  ? -17.14959 -8.26293  -7.05422  1.000 56.64368  ? 385 VAL   A CA   1 
ATOM   279  C C    . VAL   A 1 23  ? -17.36122 -8.69056  -5.60534  1.000 57.77856  ? 385 VAL   A C    1 
ATOM   280  O O    . VAL   A 1 23  ? -16.41128 -9.08448  -4.92034  1.000 50.25711  ? 385 VAL   A O    1 
ATOM   281  C CB   . VAL   A 1 23  ? -16.37419 -9.33207  -7.85221  1.000 55.44942  ? 385 VAL   A CB   1 
ATOM   282  C CG1  . VAL   A 1 23  ? -17.15299 -10.63887 -7.92697  1.000 56.04676  ? 385 VAL   A CG1  1 
ATOM   283  C CG2  . VAL   A 1 23  ? -16.10716 -8.85677  -9.27786  1.000 49.92128  ? 385 VAL   A CG2  1 
ATOM   284  H H    . VAL   A 1 23  ? -15.68283 -6.98910  -7.41201  1.000 61.00618  ? 385 VAL   A H    1 
ATOM   285  H HA   . VAL   A 1 23  ? -18.01351 -8.16438  -7.48414  1.000 67.98447  ? 385 VAL   A HA   1 
ATOM   286  H HB   . VAL   A 1 23  ? -15.53421 -9.48266  -7.39105  1.000 66.55136  ? 385 VAL   A HB   1 
ATOM   287  H HG11 . VAL   A 1 23  ? -16.64441 -11.28028 -8.44739  1.000 67.26817  ? 385 VAL   A HG11 1 
ATOM   288  H HG12 . VAL   A 1 23  ? -17.29008 -10.97667 -7.02809  1.000 67.26817  ? 385 VAL   A HG12 1 
ATOM   289  H HG13 . VAL   A 1 23  ? -18.00893 -10.47253 -8.35194  1.000 67.26817  ? 385 VAL   A HG13 1 
ATOM   290  H HG21 . VAL   A 1 23  ? -15.60483 -9.53950  -9.74949  1.000 59.91759  ? 385 VAL   A HG21 1 
ATOM   291  H HG22 . VAL   A 1 23  ? -16.95490 -8.70277  -9.72341  1.000 59.91759  ? 385 VAL   A HG22 1 
ATOM   292  H HG23 . VAL   A 1 23  ? -15.59600 -8.03302  -9.24559  1.000 59.91759  ? 385 VAL   A HG23 1 
ATOM   293  N N    . THR   A 1 24  ? -18.61326 -8.59987  -5.13980  1.000 55.12627  ? 386 THR   A N    1 
ATOM   294  C CA   . THR   A 1 24  ? -18.99858 -8.95187  -3.77654  1.000 63.59350  ? 386 THR   A CA   1 
ATOM   295  C C    . THR   A 1 24  ? -20.05644 -10.06126 -3.76176  1.000 69.51569  ? 386 THR   A C    1 
ATOM   296  O O    . THR   A 1 24  ? -20.78142 -10.22765 -2.77294  1.000 69.38839  ? 386 THR   A O    1 
ATOM   297  C CB   . THR   A 1 24  ? -19.49503 -7.70724  -3.03220  1.000 61.40350  ? 386 THR   A CB   1 
ATOM   298  O OG1  . THR   A 1 24  ? -20.55807 -7.08401  -3.76782  1.000 65.54011  ? 386 THR   A OG1  1 
ATOM   299  C CG2  . THR   A 1 24  ? -18.34662 -6.69613  -2.84624  1.000 52.22340  ? 386 THR   A CG2  1 
ATOM   300  H H    . THR   A 1 24  ? -19.27653 -8.32720  -5.61449  1.000 66.16358  ? 386 THR   A H    1 
ATOM   301  H HA   . THR   A 1 24  ? -18.22317 -9.28661  -3.29948  1.000 76.32426  ? 386 THR   A HA   1 
ATOM   302  H HB   . THR   A 1 24  ? -19.82308 -7.96953  -2.15785  1.000 73.69626  ? 386 THR   A HB   1 
ATOM   303  H HG1  . THR   A 1 24  ? -21.20617 -7.61345  -3.84030  1.000 78.66018  ? 386 THR   A HG1  1 
ATOM   304  H HG21 . THR   A 1 24  ? -18.70509 -5.82742  -2.60595  1.000 62.68013  ? 386 THR   A HG21 1 
ATOM   305  H HG22 . THR   A 1 24  ? -17.75085 -6.99654  -2.14217  1.000 62.68013  ? 386 THR   A HG22 1 
ATOM   306  H HG23 . THR   A 1 24  ? -17.84235 -6.61153  -3.67054  1.000 62.68013  ? 386 THR   A HG23 1 
ATOM   307  N N    . THR   A 1 25  ? -20.12917 -10.84629 -4.82971  1.000 63.37545  ? 387 THR   A N    1 
ATOM   308  C CA   . THR   A 1 25  ? -21.12939 -11.88901 -4.96159  1.000 63.81963  ? 387 THR   A CA   1 
ATOM   309  C C    . THR   A 1 25  ? -20.66580 -13.14479 -4.22861  1.000 60.82606  ? 387 THR   A C    1 
ATOM   310  O O    . THR   A 1 25  ? -19.53298 -13.23242 -3.75412  1.000 58.93452  ? 387 THR   A O    1 
ATOM   311  C CB   . THR   A 1 25  ? -21.39653 -12.16760 -6.44628  1.000 60.95272  ? 387 THR   A CB   1 
ATOM   312  O OG1  . THR   A 1 25  ? -20.28240 -12.85086 -7.03668  1.000 56.84527  ? 387 THR   A OG1  1 
ATOM   313  C CG2  . THR   A 1 25  ? -21.60676 -10.86292 -7.20129  1.000 58.98923  ? 387 THR   A CG2  1 
ATOM   314  H H    . THR   A 1 25  ? -19.59850 -10.79198 -5.50428  1.000 76.06259  ? 387 THR   A H    1 
ATOM   315  H HA   . THR   A 1 25  ? -21.96739 -11.60814 -4.56189  1.000 76.59561  ? 387 THR   A HA   1 
ATOM   316  H HB   . THR   A 1 25  ? -22.19212 -12.71768 -6.51943  1.000 73.15531  ? 387 THR   A HB   1 
ATOM   317  H HG1  . THR   A 1 25  ? -20.43654 -13.00409 -7.84807  1.000 68.22638  ? 387 THR   A HG1  1 
ATOM   318  H HG21 . THR   A 1 25  ? -22.02052 -11.03985 -8.06059  1.000 70.79913  ? 387 THR   A HG21 1 
ATOM   319  H HG22 . THR   A 1 25  ? -22.18255 -10.27290 -6.69018  1.000 70.79913  ? 387 THR   A HG22 1 
ATOM   320  H HG23 . THR   A 1 25  ? -20.75468 -10.42284 -7.34684  1.000 70.79913  ? 387 THR   A HG23 1 
ATOM   321  N N    . TYR   A 1 26  ? -21.56434 -14.12130 -4.12573  1.000 56.83973  ? 388 TYR   A N    1 
ATOM   322  C CA   . TYR   A 1 26  ? -21.21699 -15.41913 -3.55496  1.000 60.55872  ? 388 TYR   A CA   1 
ATOM   323  C C    . TYR   A 1 26  ? -19.99729 -16.00099 -4.26399  1.000 62.56045  ? 388 TYR   A C    1 
ATOM   324  O O    . TYR   A 1 26  ? -19.89820 -15.96820 -5.49446  1.000 60.98044  ? 388 TYR   A O    1 
ATOM   325  C CB   . TYR   A 1 26  ? -22.41786 -16.37800 -3.65026  1.000 53.55657  ? 388 TYR   A CB   1 
ATOM   326  C CG   . TYR   A 1 26  ? -22.16489 -17.75809 -3.07611  1.000 57.87497  ? 388 TYR   A CG   1 
ATOM   327  C CD1  . TYR   A 1 26  ? -21.85948 -17.93438 -1.73194  1.000 59.67881  ? 388 TYR   A CD1  1 
ATOM   328  C CD2  . TYR   A 1 26  ? -22.22978 -18.88457 -3.87891  1.000 53.69023  ? 388 TYR   A CD2  1 
ATOM   329  C CE1  . TYR   A 1 26  ? -21.61426 -19.20070 -1.21250  1.000 60.89397  ? 388 TYR   A CE1  1 
ATOM   330  C CE2  . TYR   A 1 26  ? -21.98005 -20.15181 -3.37206  1.000 61.07130  ? 388 TYR   A CE2  1 
ATOM   331  C CZ   . TYR   A 1 26  ? -21.68025 -20.30987 -2.03908  1.000 61.06802  ? 388 TYR   A CZ   1 
ATOM   332  O OH   . TYR   A 1 26  ? -21.43130 -21.57810 -1.54264  1.000 57.85013  ? 388 TYR   A OH   1 
ATOM   333  H H    . TYR   A 1 26  ? -22.38353 -14.05757 -4.37961  1.000 68.21973  ? 388 TYR   A H    1 
ATOM   334  H HA   . TYR   A 1 26  ? -20.99931 -15.31449 -2.61551  1.000 72.68252  ? 388 TYR   A HA   1 
ATOM   335  H HB2  . TYR   A 1 26  ? -23.16257 -15.99026 -3.16449  1.000 64.27994  ? 388 TYR   A HB2  1 
ATOM   336  H HB3  . TYR   A 1 26  ? -22.65261 -16.48775 -4.58500  1.000 64.27994  ? 388 TYR   A HB3  1 
ATOM   337  H HD1  . TYR   A 1 26  ? -21.81846 -17.19376 -1.17096  1.000 71.62662  ? 388 TYR   A HD1  1 
ATOM   338  H HD2  . TYR   A 1 26  ? -22.44571 -18.78951 -4.77848  1.000 64.44033  ? 388 TYR   A HD2  1 
ATOM   339  H HE1  . TYR   A 1 26  ? -21.40634 -19.30258 -0.31179  1.000 73.08482  ? 388 TYR   A HE1  1 
ATOM   340  H HE2  . TYR   A 1 26  ? -22.01532 -20.89301 -3.93267  1.000 73.29761  ? 388 TYR   A HE2  1 
ATOM   341  H HH   . TYR   A 1 26  ? -21.47014 -22.14244 -2.16362  1.000 69.43221  ? 388 TYR   A HH   1 
ATOM   342  N N    . LYS   A 1 27  ? -19.04918 -16.49369 -3.46382  1.000 64.51883  ? 389 LYS   A N    1 
ATOM   343  C CA   . LYS   A 1 27  ? -17.73464 -17.01244 -3.84433  1.000 64.32793  ? 389 LYS   A CA   1 
ATOM   344  C C    . LYS   A 1 27  ? -16.75587 -15.92083 -4.27325  1.000 55.78441  ? 389 LYS   A C    1 
ATOM   345  O O    . LYS   A 1 27  ? -15.62580 -16.25116 -4.64104  1.000 53.97020  ? 389 LYS   A O    1 
ATOM   346  C CB   . LYS   A 1 27  ? -17.78548 -18.05724 -4.96912  1.000 57.16321  ? 389 LYS   A CB   1 
ATOM   347  C CG   . LYS   A 1 27  ? -18.73572 -19.19083 -4.72978  1.000 56.42208  ? 389 LYS   A CG   1 
ATOM   348  C CD   . LYS   A 1 27  ? -18.35734 -20.04822 -3.54535  1.000 53.71626  ? 389 LYS   A CD   1 
ATOM   349  C CE   . LYS   A 1 27  ? -18.41735 -21.52896 -3.92728  1.000 57.48780  ? 389 LYS   A CE   1 
ATOM   350  N NZ   . LYS   A 1 27  ? -17.32292 -21.93980 -4.87140  1.000 54.87617  ? 389 LYS   A NZ   1 
ATOM   351  H H    . LYS   A 1 27  ? -19.15866 -16.54096 -2.61212  1.000 77.43465  ? 389 LYS   A H    1 
ATOM   352  H HA   . LYS   A 1 27  ? -17.38257 -17.44544 -3.05095  1.000 77.20558  ? 389 LYS   A HA   1 
ATOM   353  H HB2  . LYS   A 1 27  ? -18.05893 -17.61506 -5.78802  1.000 68.60790  ? 389 LYS   A HB2  1 
ATOM   354  H HB3  . LYS   A 1 27  ? -16.89942 -18.43691 -5.07703  1.000 68.60790  ? 389 LYS   A HB3  1 
ATOM   355  H HG2  . LYS   A 1 27  ? -19.62067 -18.82964 -4.56451  1.000 67.71855  ? 389 LYS   A HG2  1 
ATOM   356  H HG3  . LYS   A 1 27  ? -18.75091 -19.75949 -5.51547  1.000 67.71855  ? 389 LYS   A HG3  1 
ATOM   357  H HD2  . LYS   A 1 27  ? -17.45352 -19.83625 -3.26417  1.000 64.47157  ? 389 LYS   A HD2  1 
ATOM   358  H HD3  . LYS   A 1 27  ? -18.97731 -19.89001 -2.81630  1.000 64.47157  ? 389 LYS   A HD3  1 
ATOM   359  H HE2  . LYS   A 1 27  ? -18.33436 -22.06516 -3.12323  1.000 68.99742  ? 389 LYS   A HE2  1 
ATOM   360  H HE3  . LYS   A 1 27  ? -19.26696 -21.70848 -4.35953  1.000 68.99742  ? 389 LYS   A HE3  1 
ATOM   361  H HZ1  . LYS   A 1 27  ? -17.35494 -22.81824 -5.01074  1.000 65.86345  ? 389 LYS   A HZ1  1 
ATOM   362  H HZ2  . LYS   A 1 27  ? -17.41935 -21.52011 -5.65029  1.000 65.86345  ? 389 LYS   A HZ2  1 
ATOM   363  H HZ3  . LYS   A 1 27  ? -16.52936 -21.73073 -4.52695  1.000 65.86345  ? 389 LYS   A HZ3  1 
ATOM   364  N N    . ALA   A 1 28  ? -17.14549 -14.64772 -4.25096  1.000 52.46726  ? 390 ALA   A N    1 
ATOM   365  C CA   . ALA   A 1 28  ? -16.17327 -13.58116 -4.45872  1.000 57.07618  ? 390 ALA   A CA   1 
ATOM   366  C C    . ALA   A 1 28  ? -15.05130 -13.69649 -3.43206  1.000 63.61233  ? 390 ALA   A C    1 
ATOM   367  O O    . ALA   A 1 28  ? -15.24901 -14.19361 -2.31789  1.000 56.57491  ? 390 ALA   A O    1 
ATOM   368  C CB   . ALA   A 1 28  ? -16.82619 -12.20421 -4.34583  1.000 56.16412  ? 390 ALA   A CB   1 
ATOM   369  H H    . ALA   A 1 28  ? -17.95241 -14.38074 -4.11983  1.000 62.97276  ? 390 ALA   A H    1 
ATOM   370  H HA   . ALA   A 1 28  ? -15.80444 -13.65957 -5.35243  1.000 68.50347  ? 390 ALA   A HA   1 
ATOM   371  H HB1  . ALA   A 1 28  ? -16.15939 -11.52289 -4.52491  1.000 67.40900  ? 390 ALA   A HB1  1 
ATOM   372  H HB2  . ALA   A 1 28  ? -17.54533 -12.14163 -4.99376  1.000 67.40900  ? 390 ALA   A HB2  1 
ATOM   373  H HB3  . ALA   A 1 28  ? -17.17865 -12.09442 -3.44882  1.000 67.40900  ? 390 ALA   A HB3  1 
ATOM   374  N N    . VAL   A 1 29  ? -13.86142 -13.23859 -3.82028  1.000 55.99023  ? 391 VAL   A N    1 
ATOM   375  C CA   . VAL   A 1 29  ? -12.66653 -13.37503 -3.00232  1.000 55.15273  ? 391 VAL   A CA   1 
ATOM   376  C C    . VAL   A 1 29  ? -12.02541 -12.00263 -2.88399  1.000 57.57198  ? 391 VAL   A C    1 
ATOM   377  O O    . VAL   A 1 29  ? -11.82760 -11.31805 -3.89439  1.000 53.40861  ? 391 VAL   A O    1 
ATOM   378  C CB   . VAL   A 1 29  ? -11.67723 -14.39970 -3.59210  1.000 54.30424  ? 391 VAL   A CB   1 
ATOM   379  C CG1  . VAL   A 1 29  ? -10.40840 -14.43874 -2.77805  1.000 54.28849  ? 391 VAL   A CG1  1 
ATOM   380  C CG2  . VAL   A 1 29  ? -12.31217 -15.79755 -3.64541  1.000 57.52810  ? 391 VAL   A CG2  1 
ATOM   381  H H    . VAL   A 1 29  ? -13.72322 -12.83817 -4.56872  1.000 67.20033  ? 391 VAL   A H    1 
ATOM   382  H HA   . VAL   A 1 29  ? -12.91042 -13.67818 -2.11378  1.000 66.19533  ? 391 VAL   A HA   1 
ATOM   383  H HB   . VAL   A 1 29  ? -11.45565 -14.12882 -4.49677  1.000 65.17714  ? 391 VAL   A HB   1 
ATOM   384  H HG11 . VAL   A 1 29  ? -9.93587  -15.26403 -2.96912  1.000 65.15824  ? 391 VAL   A HG11 1 
ATOM   385  H HG12 . VAL   A 1 29  ? -9.85600  -13.67822 -3.01756  1.000 65.15824  ? 391 VAL   A HG12 1 
ATOM   386  H HG13 . VAL   A 1 29  ? -10.63620 -14.39849 -1.83603  1.000 65.15824  ? 391 VAL   A HG13 1 
ATOM   387  H HG21 . VAL   A 1 29  ? -11.66467 -16.42510 -4.00294  1.000 69.04577  ? 391 VAL   A HG21 1 
ATOM   388  H HG22 . VAL   A 1 29  ? -12.56883 -16.06225 -2.74821  1.000 69.04577  ? 391 VAL   A HG22 1 
ATOM   389  H HG23 . VAL   A 1 29  ? -13.09459 -15.76738 -4.21795  1.000 69.04577  ? 391 VAL   A HG23 1 
ATOM   390  N N    . ILE   A 1 30  ? -11.73343 -11.59875 -1.64778  1.000 50.97413  ? 392 ILE   A N    1 
ATOM   391  C CA   . ILE   A 1 30  ? -10.97950 -10.39334 -1.34444  1.000 51.83033  ? 392 ILE   A CA   1 
ATOM   392  C C    . ILE   A 1 30  ? -9.75529  -10.81670 -0.54330  1.000 53.71540  ? 392 ILE   A C    1 
ATOM   393  O O    . ILE   A 1 30  ? -9.70182  -11.91723 0.02054   1.000 48.82852  ? 392 ILE   A O    1 
ATOM   394  C CB   . ILE   A 1 30  ? -11.81154 -9.34586  -0.56995  1.000 46.59320  ? 392 ILE   A CB   1 
ATOM   395  C CG1  . ILE   A 1 30  ? -12.35853 -9.94589  0.73443   1.000 48.03917  ? 392 ILE   A CG1  1 
ATOM   396  C CG2  . ILE   A 1 30  ? -12.92711 -8.80645  -1.45586  1.000 49.26877  ? 392 ILE   A CG2  1 
ATOM   397  C CD1  . ILE   A 1 30  ? -13.12253 -8.99231  1.56679   1.000 49.20051  ? 392 ILE   A CD1  1 
ATOM   398  H H    . ILE   A 1 30  ? -11.97319 -12.02722 -0.94171  1.000 61.18101  ? 392 ILE   A H    1 
ATOM   399  H HA   . ILE   A 1 30  ? -10.69018 -9.97193  -2.16882  1.000 62.20845  ? 392 ILE   A HA   1 
ATOM   400  H HB   . ILE   A 1 30  ? -11.23598 -8.60385  -0.32696  1.000 55.92389  ? 392 ILE   A HB   1 
ATOM   401  H HG12 . ILE   A 1 30  ? -12.94975 -10.68233 0.51304   1.000 57.65906  ? 392 ILE   A HG12 1 
ATOM   402  H HG13 . ILE   A 1 30  ? -11.61259 -10.26718 1.26475   1.000 57.65906  ? 392 ILE   A HG13 1 
ATOM   403  H HG21 . ILE   A 1 30  ? -13.41695 -8.12617  -0.96783  1.000 59.13458  ? 392 ILE   A HG21 1 
ATOM   404  H HG22 . ILE   A 1 30  ? -12.53680 -8.42260  -2.25662  1.000 59.13458  ? 392 ILE   A HG22 1 
ATOM   405  H HG23 . ILE   A 1 30  ? -13.52142 -9.53509  -1.69413  1.000 59.13458  ? 392 ILE   A HG23 1 
ATOM   406  H HD11 . ILE   A 1 30  ? -13.26184 -9.38060  2.44470   1.000 59.05266  ? 392 ILE   A HD11 1 
ATOM   407  H HD12 . ILE   A 1 30  ? -12.61797 -8.16767  1.64611   1.000 59.05266  ? 392 ILE   A HD12 1 
ATOM   408  H HD13 . ILE   A 1 30  ? -13.97736 -8.81759  1.14294   1.000 59.05266  ? 392 ILE   A HD13 1 
ATOM   409  N N    . GLN   A 1 31  ? -8.77250  -9.91781  -0.48760  1.000 45.20121  ? 393 GLN   A N    1 
ATOM   410  C CA   . GLN   A 1 31  ? -7.53317  -10.16412 0.22868   1.000 44.66827  ? 393 GLN   A CA   1 
ATOM   411  C C    . GLN   A 1 31  ? -7.22792  -8.95066  1.08302   1.000 46.46254  ? 393 GLN   A C    1 
ATOM   412  O O    . GLN   A 1 31  ? -7.03736  -7.84401  0.55887   1.000 40.54944  ? 393 GLN   A O    1 
ATOM   413  C CB   . GLN   A 1 31  ? -6.37793  -10.45409 -0.72031  1.000 48.05407  ? 393 GLN   A CB   1 
ATOM   414  C CG   . GLN   A 1 31  ? -5.05783  -10.78923 -0.02563  1.000 45.61613  ? 393 GLN   A CG   1 
ATOM   415  C CD   . GLN   A 1 31  ? -5.10966  -12.13722 0.65294   1.000 46.55570  ? 393 GLN   A CD   1 
ATOM   416  O OE1  . GLN   A 1 31  ? -5.52871  -13.11057 0.05068   1.000 43.08135  ? 393 GLN   A OE1  1 
ATOM   417  N NE2  . GLN   A 1 31  ? -4.71495  -12.18777 1.92253   1.000 43.81108  ? 393 GLN   A NE2  1 
ATOM   418  H H    . GLN   A 1 31  ? -8.80608  -9.14591  -0.86529  1.000 54.25350  ? 393 GLN   A H    1 
ATOM   419  H HA   . GLN   A 1 31  ? -7.64458  -10.93589 0.80562   1.000 53.61398  ? 393 GLN   A HA   1 
ATOM   420  H HB2  . GLN   A 1 31  ? -6.61736  -11.21195 -1.27638  1.000 57.67694  ? 393 GLN   A HB2  1 
ATOM   421  H HB3  . GLN   A 1 31  ? -6.22795  -9.67125  -1.27309  1.000 57.67694  ? 393 GLN   A HB3  1 
ATOM   422  H HG2  . GLN   A 1 31  ? -4.34539  -10.80701 -0.68367  1.000 54.75142  ? 393 GLN   A HG2  1 
ATOM   423  H HG3  . GLN   A 1 31  ? -4.87075  -10.11658 0.64776   1.000 54.75142  ? 393 GLN   A HG3  1 
ATOM   424  H HE21 . GLN   A 1 31  ? -4.44658  -11.47291 2.31819   1.000 52.58535  ? 393 GLN   A HE21 1 
ATOM   425  H HE22 . GLN   A 1 31  ? -4.72818  -12.93532 2.34750   1.000 52.58535  ? 393 GLN   A HE22 1 
ATOM   426  N N    . TYR   A 1 32  ? -7.20383  -9.17119  2.38927   1.000 41.69796  ? 394 TYR   A N    1 
ATOM   427  C CA   . TYR   A 1 32  ? -6.65521  -8.20800  3.32313   1.000 46.21803  ? 394 TYR   A CA   1 
ATOM   428  C C    . TYR   A 1 32  ? -5.14555  -8.36816  3.39218   1.000 38.81464  ? 394 TYR   A C    1 
ATOM   429  O O    . TYR   A 1 32  ? -4.60926  -9.46094  3.21380   1.000 40.91968  ? 394 TYR   A O    1 
ATOM   430  C CB   . TYR   A 1 32  ? -7.25941  -8.41755  4.70577   1.000 43.38079  ? 394 TYR   A CB   1 
ATOM   431  C CG   . TYR   A 1 32  ? -8.68915  -7.96771  4.82127   1.000 41.97475  ? 394 TYR   A CG   1 
ATOM   432  C CD1  . TYR   A 1 32  ? -8.98869  -6.64210  5.03017   1.000 42.85252  ? 394 TYR   A CD1  1 
ATOM   433  C CD2  . TYR   A 1 32  ? -9.72810  -8.87219  4.75620   1.000 46.39926  ? 394 TYR   A CD2  1 
ATOM   434  C CE1  . TYR   A 1 32  ? -10.28144 -6.21332  5.15470   1.000 47.56713  ? 394 TYR   A CE1  1 
ATOM   435  C CE2  . TYR   A 1 32  ? -11.03948 -8.45572  4.87526   1.000 46.82063  ? 394 TYR   A CE2  1 
ATOM   436  C CZ   . TYR   A 1 32  ? -11.30572 -7.12528  5.07380   1.000 54.09600  ? 394 TYR   A CZ   1 
ATOM   437  O OH   . TYR   A 1 32  ? -12.59601 -6.69038  5.20749   1.000 58.17566  ? 394 TYR   A OH   1 
ATOM   438  H H    . TYR   A 1 32  ? -7.50488  -9.88409  2.76444   1.000 50.04960  ? 394 TYR   A H    1 
ATOM   439  H HA   . TYR   A 1 32  ? -6.86202  -7.30475  3.03631   1.000 55.47369  ? 394 TYR   A HA   1 
ATOM   440  H HB2  . TYR   A 1 32  ? -7.22938  -9.36349  4.91834   1.000 52.06900  ? 394 TYR   A HB2  1 
ATOM   441  H HB3  . TYR   A 1 32  ? -6.73877  -7.91556  5.35217   1.000 52.06900  ? 394 TYR   A HB3  1 
ATOM   442  H HD1  . TYR   A 1 32  ? -8.29685  -6.02330  5.08808   1.000 51.43507  ? 394 TYR   A HD1  1 
ATOM   443  H HD2  . TYR   A 1 32  ? -9.54315  -9.77490  4.63043   1.000 55.69116  ? 394 TYR   A HD2  1 
ATOM   444  H HE1  . TYR   A 1 32  ? -10.46550 -5.31226  5.29295   1.000 57.09262  ? 394 TYR   A HE1  1 
ATOM   445  H HE2  . TYR   A 1 32  ? -11.73467 -9.07111  4.82134   1.000 56.19681  ? 394 TYR   A HE2  1 
ATOM   446  H HH   . TYR   A 1 32  ? -12.60601 -5.86650  5.37095   1.000 69.82285  ? 394 TYR   A HH   1 
ATOM   447  N N    . SER   A 1 33  ? -4.45710  -7.27966  3.70086   1.000 41.18740  ? 395 SER   A N    1 
ATOM   448  C CA   . SER   A 1 33  ? -3.01832  -7.34545  3.88801   1.000 44.80041  ? 395 SER   A CA   1 
ATOM   449  C C    . SER   A 1 33  ? -2.58824  -6.22385  4.81557   1.000 46.94261  ? 395 SER   A C    1 
ATOM   450  O O    . SER   A 1 33  ? -3.26679  -5.19627  4.93487   1.000 36.48552  ? 395 SER   A O    1 
ATOM   451  C CB   . SER   A 1 33  ? -2.27972  -7.25655  2.55178   1.000 47.23288  ? 395 SER   A CB   1 
ATOM   452  O OG   . SER   A 1 33  ? -2.49442  -6.01088  1.94091   1.000 47.62824  ? 395 SER   A OG   1 
ATOM   453  H H    . SER   A 1 33  ? -4.79825  -6.49732  3.80651   1.000 49.43693  ? 395 SER   A H    1 
ATOM   454  H HA   . SER   A 1 33  ? -2.77919  -8.18607  4.30880   1.000 53.77255  ? 395 SER   A HA   1 
ATOM   455  H HB2  . SER   A 1 33  ? -1.32937  -7.37111  2.70866   1.000 56.69152  ? 395 SER   A HB2  1 
ATOM   456  H HB3  . SER   A 1 33  ? -2.60568  -7.95615  1.96425   1.000 56.69152  ? 395 SER   A HB3  1 
ATOM   457  H HG   . SER   A 1 33  ? -2.09378  -5.97978  1.20326   1.000 57.16595  ? 395 SER   A HG   1 
ATOM   458  N N    . CYS   A 1 34  ? -1.47269  -6.45288  5.49633   1.000 48.57899  ? 396 CYS   A N    1 
ATOM   459  C CA   . CYS   A 1 34  ? -0.82084  -5.46708  6.33399   1.000 50.72976  ? 396 CYS   A CA   1 
ATOM   460  C C    . CYS   A 1 34  ? 0.42086   -4.96306  5.62185   1.000 49.04437  ? 396 CYS   A C    1 
ATOM   461  O O    . CYS   A 1 34  ? 0.94113   -5.61512  4.71477   1.000 52.22575  ? 396 CYS   A O    1 
ATOM   462  C CB   . CYS   A 1 34  ? -0.41839  -6.07400  7.68111   1.000 54.17089  ? 396 CYS   A CB   1 
ATOM   463  S SG   . CYS   A 1 34  ? -1.76836  -6.79448  8.63222   1.000 42.49506  ? 396 CYS   A SG   1 
ATOM   464  H H    . CYS   A 1 34  ? -1.05930  -7.20693  5.48569   1.000 58.30685  ? 396 CYS   A H    1 
ATOM   465  H HA   . CYS   A 1 34  ? -1.42302  -4.72570  6.50322   1.000 60.88777  ? 396 CYS   A HA   1 
ATOM   466  H HB2  . CYS   A 1 34  ? 0.22952   -6.77734  7.51858   1.000 65.01712  ? 396 CYS   A HB2  1 
ATOM   467  H HB3  . CYS   A 1 34  ? -0.02088  -5.37591  8.22477   1.000 65.01712  ? 396 CYS   A HB3  1 
ATOM   468  N N    . GLU   A 1 35  ? 0.91472   -3.81702  6.06775   1.000 56.17878  ? 397 GLU   A N    1 
ATOM   469  C CA   . GLU   A 1 35  ? 2.28036   -3.39773  5.74352   1.000 57.09138  ? 397 GLU   A CA   1 
ATOM   470  C C    . GLU   A 1 35  ? 3.21922   -4.34426  6.47864   1.000 57.28618  ? 397 GLU   A C    1 
ATOM   471  O O    . GLU   A 1 35  ? 3.45410   -4.18961  7.67630   1.000 58.88777  ? 397 GLU   A O    1 
ATOM   472  C CB   . GLU   A 1 35  ? 2.48869   -1.94221  6.14120   1.000 51.53275  ? 397 GLU   A CB   1 
ATOM   473  C CG   . GLU   A 1 35  ? 3.76609   -1.23925  5.59551   1.000 74.00124  ? 397 GLU   A CG   1 
ATOM   474  C CD   . GLU   A 1 35  ? 5.09032   -1.89839  6.00191   1.000 63.24534  ? 397 GLU   A CD   1 
ATOM   475  O OE1  . GLU   A 1 35  ? 5.54937   -1.64537  7.12937   1.000 55.93332  ? 397 GLU   A OE1  1 
ATOM   476  O OE2  . GLU   A 1 35  ? 5.63983   -2.70854  5.21810   1.000 54.22293  ? 397 GLU   A OE2  1 
ATOM   477  H H    . GLU   A 1 35  ? 0.48219   -3.26068  6.56070   1.000 67.42660  ? 397 GLU   A H    1 
ATOM   478  H HA   . GLU   A 1 35  ? 2.45367   -3.45888  4.79109   1.000 68.52171  ? 397 GLU   A HA   1 
ATOM   479  H HB2  . GLU   A 1 35  ? 1.72748   -1.43259  5.82225   1.000 61.85135  ? 397 GLU   A HB2  1 
ATOM   480  H HB3  . GLU   A 1 35  ? 2.53431   -1.89970  7.10920   1.000 61.85135  ? 397 GLU   A HB3  1 
ATOM   481  H HG2  . GLU   A 1 35  ? 3.72695   -1.23900  4.62630   1.000 88.81354  ? 397 GLU   A HG2  1 
ATOM   482  H HG3  . GLU   A 1 35  ? 3.78125   -0.32784  5.92716   1.000 88.81354  ? 397 GLU   A HG3  1 
ATOM   483  N N    . GLU   A 1 36  ? 3.78632   -5.32060  5.75688   1.000 60.55157  ? 398 GLU   A N    1 
ATOM   484  C CA   . GLU   A 1 36  ? 4.45783   -6.44995  6.39759   1.000 57.94521  ? 398 GLU   A CA   1 
ATOM   485  C C    . GLU   A 1 36  ? 5.84011   -6.12685  6.97553   1.000 60.68735  ? 398 GLU   A C    1 
ATOM   486  O O    . GLU   A 1 36  ? 6.38990   -6.97043  7.70228   1.000 51.23789  ? 398 GLU   A O    1 
ATOM   487  C CB   . GLU   A 1 36  ? 4.59449   -7.61974  5.41078   1.000 58.49077  ? 398 GLU   A CB   1 
ATOM   488  C CG   . GLU   A 1 36  ? 3.37382   -8.54243  5.32982   1.000 63.59516  ? 398 GLU   A CG   1 
ATOM   489  C CD   . GLU   A 1 36  ? 3.07077   -9.23543  6.65900   1.000 59.89856  ? 398 GLU   A CD   1 
ATOM   490  O OE1  . GLU   A 1 36  ? 4.03312   -9.71825  7.29517   1.000 60.20981  ? 398 GLU   A OE1  1 
ATOM   491  O OE2  . GLU   A 1 36  ? 1.88485   -9.29732  7.06655   1.000 49.97504  ? 398 GLU   A OE2  1 
ATOM   492  H H    . GLU   A 1 36  ? 3.79357   -5.34830  4.89736   1.000 72.67394  ? 398 GLU   A H    1 
ATOM   493  H HA   . GLU   A 1 36  ? 3.89679   -6.72915  7.13798   1.000 69.54631  ? 398 GLU   A HA   1 
ATOM   494  H HB2  . GLU   A 1 36  ? 4.74486   -7.25737  4.52366   1.000 70.20098  ? 398 GLU   A HB2  1 
ATOM   495  H HB3  . GLU   A 1 36  ? 5.35209   -8.16220  5.68037   1.000 70.20098  ? 398 GLU   A HB3  1 
ATOM   496  H HG2  . GLU   A 1 36  ? 2.59675   -8.01825  5.08023   1.000 76.32624  ? 398 GLU   A HG2  1 
ATOM   497  H HG3  . GLU   A 1 36  ? 3.53906   -9.22836  4.66416   1.000 76.32624  ? 398 GLU   A HG3  1 
ATOM   498  N N    . THR   A 1 37  ? 6.41789   -4.95007  6.70305   1.000 54.34515  ? 399 THR   A N    1 
ATOM   499  C CA   . THR   A 1 37  ? 7.72569   -4.65522  7.28224   1.000 53.97697  ? 399 THR   A CA   1 
ATOM   500  C C    . THR   A 1 37  ? 7.60106   -4.37471  8.77384   1.000 50.77380  ? 399 THR   A C    1 
ATOM   501  O O    . THR   A 1 37  ? 8.30095   -4.99140  9.58260   1.000 54.80823  ? 399 THR   A O    1 
ATOM   502  C CB   . THR   A 1 37  ? 8.40020   -3.48919  6.55954   1.000 51.64106  ? 399 THR   A CB   1 
ATOM   503  O OG1  . THR   A 1 37  ? 8.56340   -3.82498  5.18326   1.000 44.18970  ? 399 THR   A OG1  1 
ATOM   504  C CG2  . THR   A 1 37  ? 9.78417   -3.19785  7.12849   1.000 51.37217  ? 399 THR   A CG2  1 
ATOM   505  H H    . THR   A 1 37  ? 6.08456   -4.33265  6.20577   1.000 65.22623  ? 399 THR   A H    1 
ATOM   506  H HA   . THR   A 1 37  ? 8.29714   -5.42946  7.16018   1.000 64.78442  ? 399 THR   A HA   1 
ATOM   507  H HB   . THR   A 1 37  ? 7.84723   -2.69969  6.66821   1.000 61.98133  ? 399 THR   A HB   1 
ATOM   508  H HG1  . THR   A 1 37  ? 8.35321   -4.62834  5.05666   1.000 53.03969  ? 399 THR   A HG1  1 
ATOM   509  H HG21 . THR   A 1 37  ? 10.20241  -2.47763  6.63124   1.000 61.65866  ? 399 THR   A HG21 1 
ATOM   510  H HG22 . THR   A 1 37  ? 9.71175   -2.93673  8.05987   1.000 61.65866  ? 399 THR   A HG22 1 
ATOM   511  H HG23 . THR   A 1 37  ? 10.34192  -3.98898  7.06581   1.000 61.65866  ? 399 THR   A HG23 1 
ATOM   512  N N    . PHE   A 1 38  ? 6.72316   -3.44825  9.15331   1.000 41.39289  ? 400 PHE   A N    1 
ATOM   513  C CA   . PHE   A 1 38  ? 6.57421   -3.03774  10.54543  1.000 48.71675  ? 400 PHE   A CA   1 
ATOM   514  C C    . PHE   A 1 38  ? 5.29154   -3.54571  11.19035  1.000 47.46680  ? 400 PHE   A C    1 
ATOM   515  O O    . PHE   A 1 38  ? 5.05270   -3.25382  12.36913  1.000 35.55087  ? 400 PHE   A O    1 
ATOM   516  C CB   . PHE   A 1 38  ? 6.63964   -1.50839  10.65764  1.000 47.90521  ? 400 PHE   A CB   1 
ATOM   517  C CG   . PHE   A 1 38  ? 7.94631   -0.92565  10.17814  1.000 53.69357  ? 400 PHE   A CG   1 
ATOM   518  C CD1  . PHE   A 1 38  ? 8.14343   -0.63380  8.83509   1.000 51.77674  ? 400 PHE   A CD1  1 
ATOM   519  C CD2  . PHE   A 1 38  ? 8.99387   -0.70851  11.06238  1.000 55.73528  ? 400 PHE   A CD2  1 
ATOM   520  C CE1  . PHE   A 1 38  ? 9.34520   -0.10532  8.38713   1.000 50.86142  ? 400 PHE   A CE1  1 
ATOM   521  C CE2  . PHE   A 1 38  ? 10.20231  -0.19067  10.61451  1.000 51.57063  ? 400 PHE   A CE2  1 
ATOM   522  C CZ   . PHE   A 1 38  ? 10.37404  0.11161   9.27888   1.000 56.91538  ? 400 PHE   A CZ   1 
ATOM   523  H H    . PHE   A 1 38  ? 6.19480   -3.03724  8.61339   1.000 49.68352  ? 400 PHE   A H    1 
ATOM   524  H HA   . PHE   A 1 38  ? 7.31689   -3.40475  11.05004  1.000 58.47216  ? 400 PHE   A HA   1 
ATOM   525  H HB2  . PHE   A 1 38  ? 5.92840   -1.12454  10.12127  1.000 57.49831  ? 400 PHE   A HB2  1 
ATOM   526  H HB3  . PHE   A 1 38  ? 6.52595   -1.25771  11.58777  1.000 57.49831  ? 400 PHE   A HB3  1 
ATOM   527  H HD1  . PHE   A 1 38  ? 7.45910   -0.79513  8.22635   1.000 62.14414  ? 400 PHE   A HD1  1 
ATOM   528  H HD2  . PHE   A 1 38  ? 8.88559   -0.91172  11.96342  1.000 66.89439  ? 400 PHE   A HD2  1 
ATOM   529  H HE1  . PHE   A 1 38  ? 9.45664   0.10216   7.48744   1.000 61.04576  ? 400 PHE   A HE1  1 
ATOM   530  H HE2  . PHE   A 1 38  ? 10.89713  -0.04733  11.21583  1.000 61.89681  ? 400 PHE   A HE2  1 
ATOM   531  H HZ   . PHE   A 1 38  ? 11.18267  0.46115   8.98081   1.000 68.31051  ? 400 PHE   A HZ   1 
ATOM   532  N N    . TYR   A 1 39  ? 4.45453   -4.27863  10.44913  1.000 46.67182  ? 401 TYR   A N    1 
ATOM   533  C CA   . TYR   A 1 39  ? 3.24167   -4.88865  10.97899  1.000 43.37454  ? 401 TYR   A CA   1 
ATOM   534  C C    . TYR   A 1 39  ? 3.21460   -6.34106  10.52210  1.000 48.96490  ? 401 TYR   A C    1 
ATOM   535  O O    . TYR   A 1 39  ? 3.87462   -6.71147  9.54915   1.000 55.92966  ? 401 TYR   A O    1 
ATOM   536  C CB   . TYR   A 1 39  ? 1.96830   -4.14065  10.51845  1.000 38.07541  ? 401 TYR   A CB   1 
ATOM   537  C CG   . TYR   A 1 39  ? 1.92302   -2.68829  10.91397  1.000 34.43791  ? 401 TYR   A CG   1 
ATOM   538  C CD1  . TYR   A 1 39  ? 2.61747   -1.72874  10.19304  1.000 35.97958  ? 401 TYR   A CD1  1 
ATOM   539  C CD2  . TYR   A 1 39  ? 1.17026   -2.26915  12.00731  1.000 38.27862  ? 401 TYR   A CD2  1 
ATOM   540  C CE1  . TYR   A 1 39  ? 2.57148   -0.40382  10.54790  1.000 33.42347  ? 401 TYR   A CE1  1 
ATOM   541  C CE2  . TYR   A 1 39  ? 1.12654   -0.95154  12.37243  1.000 35.62866  ? 401 TYR   A CE2  1 
ATOM   542  C CZ   . TYR   A 1 39  ? 1.83836   -0.02414  11.63891  1.000 37.27268  ? 401 TYR   A CZ   1 
ATOM   543  O OH   . TYR   A 1 39  ? 1.80015   1.29768   11.99081  1.000 39.83186  ? 401 TYR   A OH   1 
ATOM   544  H H    . TYR   A 1 39  ? 4.57549   -4.43857  9.61284   1.000 56.01824  ? 401 TYR   A H    1 
ATOM   545  H HA   . TYR   A 1 39  ? 3.24337   -4.86380  11.94867  1.000 52.06150  ? 401 TYR   A HA   1 
ATOM   546  H HB2  . TYR   A 1 39  ? 1.91759   -4.18290  9.55070   1.000 45.70255  ? 401 TYR   A HB2  1 
ATOM   547  H HB3  . TYR   A 1 39  ? 1.19505   -4.57573  10.91049  1.000 45.70255  ? 401 TYR   A HB3  1 
ATOM   548  H HD1  . TYR   A 1 39  ? 3.12299   -1.98741  9.45654   1.000 43.18755  ? 401 TYR   A HD1  1 
ATOM   549  H HD2  . TYR   A 1 39  ? 0.68884   -2.89560  12.49792  1.000 45.94640  ? 401 TYR   A HD2  1 
ATOM   550  H HE1  . TYR   A 1 39  ? 3.03497   0.23090   10.05071  1.000 40.12021  ? 401 TYR   A HE1  1 
ATOM   551  H HE2  . TYR   A 1 39  ? 0.62273   -0.68365  13.10680  1.000 42.76644  ? 401 TYR   A HE2  1 
ATOM   552  H HH   . TYR   A 1 39  ? 1.29768   1.40360   12.65557  1.000 47.81029  ? 401 TYR   A HH   1 
ATOM   553  N N    . THR   A 1 40  ? 2.49310   -7.17757  11.26040  1.000 41.18941  ? 402 THR   A N    1 
ATOM   554  C CA   . THR   A 1 40  ? 2.31897   -8.57218  10.87693  1.000 46.79955  ? 402 THR   A CA   1 
ATOM   555  C C    . THR   A 1 40  ? 0.85467   -8.90756  11.08217  1.000 42.21212  ? 402 THR   A C    1 
ATOM   556  O O    . THR   A 1 40  ? 0.27511   -8.55837  12.11605  1.000 40.17303  ? 402 THR   A O    1 
ATOM   557  C CB   . THR   A 1 40  ? 3.20719   -9.53318  11.68868  1.000 54.40398  ? 402 THR   A CB   1 
ATOM   558  O OG1  . THR   A 1 40  ? 2.78263   -9.56555  13.05511  1.000 50.58010  ? 402 THR   A OG1  1 
ATOM   559  C CG2  . THR   A 1 40  ? 4.66450   -9.08608  11.65178  1.000 62.50337  ? 402 THR   A CG2  1 
ATOM   560  H H    . THR   A 1 40  ? 2.09354   -6.95958  11.99007  1.000 49.43934  ? 402 THR   A H    1 
ATOM   561  H HA   . THR   A 1 40  ? 2.56538   -8.69149  9.94636   1.000 56.17151  ? 402 THR   A HA   1 
ATOM   562  H HB   . THR   A 1 40  ? 3.13604   -10.41932 11.30061  1.000 65.29683  ? 402 THR   A HB   1 
ATOM   563  H HG1  . THR   A 1 40  ? 3.25532   -10.10682 13.49008  1.000 60.70817  ? 402 THR   A HG1  1 
ATOM   564  H HG21 . THR   A 1 40  ? 5.24695   -9.83711  11.84565  1.000 75.01609  ? 402 THR   A HG21 1 
ATOM   565  H HG22 . THR   A 1 40  ? 4.88237   -8.73732  10.77326  1.000 75.01609  ? 402 THR   A HG22 1 
ATOM   566  H HG23 . THR   A 1 40  ? 4.81539   -8.39196  12.31233  1.000 75.01609  ? 402 THR   A HG23 1 
ATOM   567  N N    . MET   A 1 41  ? 0.24824   -9.53581  10.08753  1.000 45.22819  ? 403 MET   A N    1 
ATOM   568  C CA   . MET   A 1 41  ? -1.15301  -9.89912  10.20919  1.000 40.76943  ? 403 MET   A CA   1 
ATOM   569  C C    . MET   A 1 41  ? -1.30390  -11.03882 11.20142  1.000 42.28772  ? 403 MET   A C    1 
ATOM   570  O O    . MET   A 1 41  ? -0.50606  -11.97505 11.22456  1.000 41.42038  ? 403 MET   A O    1 
ATOM   571  C CB   . MET   A 1 41  ? -1.72900  -10.30497 8.85854   1.000 46.76847  ? 403 MET   A CB   1 
ATOM   572  C CG   . MET   A 1 41  ? -3.24021  -10.36119 8.87111   1.000 60.70761  ? 403 MET   A CG   1 
ATOM   573  S SD   . MET   A 1 41  ? -3.92702  -11.00642 7.34244   1.000 55.76154  ? 403 MET   A SD   1 
ATOM   574  C CE   . MET   A 1 41  ? -4.17222  -9.46851  6.53037   1.000 40.87494  ? 403 MET   A CE   1 
ATOM   575  H H    . MET   A 1 41  ? 0.61891   -9.75944  9.34443   1.000 54.28588  ? 403 MET   A H    1 
ATOM   576  H HA   . MET   A 1 41  ? -1.65551  -9.12840  10.51642  1.000 48.93537  ? 403 MET   A HA   1 
ATOM   577  H HB2  . MET   A 1 41  ? -1.45635  -9.65732  8.18988   1.000 56.13422  ? 403 MET   A HB2  1 
ATOM   578  H HB3  . MET   A 1 41  ? -1.39591  -11.18506 8.62319   1.000 56.13422  ? 403 MET   A HB3  1 
ATOM   579  H HG2  . MET   A 1 41  ? -3.52864  -10.93771 9.59591   1.000 72.86119  ? 403 MET   A HG2  1 
ATOM   580  H HG3  . MET   A 1 41  ? -3.58836  -9.46522  9.00123   1.000 72.86119  ? 403 MET   A HG3  1 
ATOM   581  H HE1  . MET   A 1 41  ? -4.56161  -9.63112  5.65696   1.000 49.06198  ? 403 MET   A HE1  1 
ATOM   582  H HE2  . MET   A 1 41  ? -4.77110  -8.92209  7.06298   1.000 49.06198  ? 403 MET   A HE2  1 
ATOM   583  H HE3  . MET   A 1 41  ? -3.31623  -9.02273  6.43311   1.000 49.06198  ? 403 MET   A HE3  1 
ATOM   584  N N    . LYS   A 1 42  ? -2.32044  -10.93325 12.03822  1.000 41.61001  ? 404 LYS   A N    1 
ATOM   585  C CA   . LYS   A 1 42  ? -2.70095  -11.95999 12.98492  1.000 40.08305  ? 404 LYS   A CA   1 
ATOM   586  C C    . LYS   A 1 42  ? -4.09867  -12.45049 12.61655  1.000 47.28617  ? 404 LYS   A C    1 
ATOM   587  O O    . LYS   A 1 42  ? -4.78238  -11.84607 11.78969  1.000 45.82743  ? 404 LYS   A O    1 
ATOM   588  C CB   . LYS   A 1 42  ? -2.65398  -11.41385 14.41521  1.000 46.69725  ? 404 LYS   A CB   1 
ATOM   589  C CG   . LYS   A 1 42  ? -1.25547  -10.98282 14.86388  1.000 44.29952  ? 404 LYS   A CG   1 
ATOM   590  C CD   . LYS   A 1 42  ? -0.48235  -12.17689 15.42943  1.000 56.55922  ? 404 LYS   A CD   1 
ATOM   591  C CE   . LYS   A 1 42  ? 1.00321   -11.87756 15.62723  1.000 60.28453  ? 404 LYS   A CE   1 
ATOM   592  N NZ   . LYS   A 1 42  ? 1.81554   -13.13590 15.62171  1.000 67.85916  ? 404 LYS   A NZ   1 
ATOM   593  H H    . LYS   A 1 42  ? -2.82909  -10.24088 12.07697  1.000 49.94407  ? 404 LYS   A H    1 
ATOM   594  H HA   . LYS   A 1 42  ? -2.09315  -12.71499 12.94669  1.000 48.11171  ? 404 LYS   A HA   1 
ATOM   595  H HB2  . LYS   A 1 42  ? -3.23541  -10.63956 14.47275  1.000 56.04875  ? 404 LYS   A HB2  1 
ATOM   596  H HB3  . LYS   A 1 42  ? -2.96042  -12.10476 15.02319  1.000 56.04875  ? 404 LYS   A HB3  1 
ATOM   597  H HG2  . LYS   A 1 42  ? -0.76546  -10.62855 14.10540  1.000 53.17148  ? 404 LYS   A HG2  1 
ATOM   598  H HG3  . LYS   A 1 42  ? -1.32985  -10.30704 15.55575  1.000 53.17148  ? 404 LYS   A HG3  1 
ATOM   599  H HD2  . LYS   A 1 42  ? -0.85702  -12.41731 16.29124  1.000 67.88312  ? 404 LYS   A HD2  1 
ATOM   600  H HD3  . LYS   A 1 42  ? -0.55846  -12.92335 14.81469  1.000 67.88312  ? 404 LYS   A HD3  1 
ATOM   601  H HE2  . LYS   A 1 42  ? 1.31581   -11.30819 14.90681  1.000 72.35349  ? 404 LYS   A HE2  1 
ATOM   602  H HE3  . LYS   A 1 42  ? 1.13166   -11.43397 16.48024  1.000 72.35349  ? 404 LYS   A HE3  1 
ATOM   603  H HZ1  . LYS   A 1 42  ? 2.67752   -12.94223 15.72929  1.000 81.44305  ? 404 LYS   A HZ1  1 
ATOM   604  H HZ2  . LYS   A 1 42  ? 1.55453   -13.66962 16.28437  1.000 81.44305  ? 404 LYS   A HZ2  1 
ATOM   605  H HZ3  . LYS   A 1 42  ? 1.70984   -13.56306 14.84811  1.000 81.44305  ? 404 LYS   A HZ3  1 
ATOM   606  N N    . VAL   A 1 43  ? -4.49136  -13.57064 13.23360  1.000 42.24651  ? 405 VAL   A N    1 
ATOM   607  C CA   . VAL   A 1 43  ? -5.79840  -14.22323 13.13204  1.000 50.63247  ? 405 VAL   A CA   1 
ATOM   608  C C    . VAL   A 1 43  ? -5.82312  -15.17041 11.93038  1.000 53.39893  ? 405 VAL   A C    1 
ATOM   609  O O    . VAL   A 1 43  ? -5.89486  -16.39051 12.11333  1.000 56.04052  ? 405 VAL   A O    1 
ATOM   610  C CB   . VAL   A 1 43  ? -6.97857  -13.22630 13.08290  1.000 53.51875  ? 405 VAL   A CB   1 
ATOM   611  C CG1  . VAL   A 1 43  ? -8.29055  -13.96816 13.05905  1.000 49.40282  ? 405 VAL   A CG1  1 
ATOM   612  C CG2  . VAL   A 1 43  ? -6.95521  -12.28521 14.28924  1.000 50.86578  ? 405 VAL   A CG2  1 
ATOM   613  H H    . VAL   A 1 43  ? -3.97301  -14.00843 13.76204  1.000 50.70787  ? 405 VAL   A H    1 
ATOM   614  H HA   . VAL   A 1 43  ? -5.91109  -14.75212 13.93732  1.000 60.77101  ? 405 VAL   A HA   1 
ATOM   615  H HB   . VAL   A 1 43  ? -6.89180  -12.69726 12.27451  1.000 64.23456  ? 405 VAL   A HB   1 
ATOM   616  H HG11 . VAL   A 1 43  ? -9.00461  -13.35451 13.29238  1.000 59.29544  ? 405 VAL   A HG11 1 
ATOM   617  H HG12 . VAL   A 1 43  ? -8.43685  -14.32246 12.16800  1.000 59.29544  ? 405 VAL   A HG12 1 
ATOM   618  H HG13 . VAL   A 1 43  ? -8.25476  -14.69378 13.70178  1.000 59.29544  ? 405 VAL   A HG13 1 
ATOM   619  H HG21 . VAL   A 1 43  ? -7.74371  -11.72079 14.26477  1.000 61.05099  ? 405 VAL   A HG21 1 
ATOM   620  H HG22 . VAL   A 1 43  ? -6.95212  -12.81411 15.10236  1.000 61.05099  ? 405 VAL   A HG22 1 
ATOM   621  H HG23 . VAL   A 1 43  ? -6.15534  -11.73807 14.24750  1.000 61.05099  ? 405 VAL   A HG23 1 
ATOM   622  N N    . ASN   A 1 44  ? -5.77174  -14.63679 10.70310  1.000 48.18443  ? 406 ASN   A N    1 
ATOM   623  C CA   . ASN   A 1 44  ? -5.89218  -15.45611 9.49872   1.000 55.55235  ? 406 ASN   A CA   1 
ATOM   624  C C    . ASN   A 1 44  ? -4.94467  -14.93326 8.42364   1.000 57.49796  ? 406 ASN   A C    1 
ATOM   625  O O    . ASN   A 1 44  ? -4.20452  -13.96943 8.63446   1.000 52.42527  ? 406 ASN   A O    1 
ATOM   626  C CB   . ASN   A 1 44  ? -7.34922  -15.50023 8.98388   1.000 62.15619  ? 406 ASN   A CB   1 
ATOM   627  C CG   . ASN   A 1 44  ? -7.95710  -14.12362 8.77702   1.000 57.32118  ? 406 ASN   A CG   1 
ATOM   628  O OD1  . ASN   A 1 44  ? -7.43196  -13.29279 8.02287   1.000 52.43792  ? 406 ASN   A OD1  1 
ATOM   629  N ND2  . ASN   A 1 44  ? -9.08782  -13.88249 9.43172   1.000 53.92065  ? 406 ASN   A ND2  1 
ATOM   630  H H    . ASN   A 1 44  ? -5.66713  -13.79781 10.54572  1.000 57.83337  ? 406 ASN   A H    1 
ATOM   631  H HA   . ASN   A 1 44  ? -5.61829  -16.35924 9.72289   1.000 66.67488  ? 406 ASN   A HA   1 
ATOM   632  H HB2  . ASN   A 1 44  ? -7.36713  -15.96419 8.13222   1.000 74.59948  ? 406 ASN   A HB2  1 
ATOM   633  H HB3  . ASN   A 1 44  ? -7.89633  -15.97272 9.63065   1.000 74.59948  ? 406 ASN   A HB3  1 
ATOM   634  H HD21 . ASN   A 1 44  ? -9.47653  -13.11951 9.35201   1.000 64.71684  ? 406 ASN   A HD21 1 
ATOM   635  H HD22 . ASN   A 1 44  ? -9.43099  -14.48941 9.93520   1.000 64.71684  ? 406 ASN   A HD22 1 
ATOM   636  N N    . ASP   A 1 45  ? -4.96570  -15.59371 7.26180   1.000 59.08664  ? 407 ASP   A N    1 
ATOM   637  C CA   . ASP   A 1 45  ? -4.15262  -15.21474 6.11467   1.000 52.42824  ? 407 ASP   A CA   1 
ATOM   638  C C    . ASP   A 1 45  ? -4.73263  -14.05509 5.31118   1.000 51.86222  ? 407 ASP   A C    1 
ATOM   639  O O    . ASP   A 1 45  ? -4.17508  -13.72051 4.26540   1.000 47.97064  ? 407 ASP   A O    1 
ATOM   640  C CB   . ASP   A 1 45  ? -3.96148  -16.41524 5.17820   1.000 54.86501  ? 407 ASP   A CB   1 
ATOM   641  C CG   . ASP   A 1 45  ? -5.26988  -16.92156 4.56375   1.000 54.03754  ? 407 ASP   A CG   1 
ATOM   642  O OD1  . ASP   A 1 45  ? -6.37350  -16.36065 4.78747   1.000 47.56204  ? 407 ASP   A OD1  1 
ATOM   643  O OD2  . ASP   A 1 45  ? -5.16681  -17.92044 3.83602   1.000 58.48323  ? 407 ASP   A OD2  1 
ATOM   644  H H    . ASP   A 1 45  ? -5.45796  -16.28319 7.11384   1.000 70.91602  ? 407 ASP   A H    1 
ATOM   645  H HA   . ASP   A 1 45  ? -3.28399  -14.94203 6.44935   1.000 62.92594  ? 407 ASP   A HA   1 
ATOM   646  H HB2  . ASP   A 1 45  ? -3.37286  -16.15602 4.45209   1.000 65.85007  ? 407 ASP   A HB2  1 
ATOM   647  H HB3  . ASP   A 1 45  ? -3.56698  -17.14524 5.68058   1.000 65.85007  ? 407 ASP   A HB3  1 
ATOM   648  N N    . GLY   A 1 46  ? -5.85842  -13.47535 5.73125   1.000 47.72076  ? 408 GLY   A N    1 
ATOM   649  C CA   . GLY   A 1 46  ? -6.44513  -12.34646 5.04424   1.000 50.32294  ? 408 GLY   A CA   1 
ATOM   650  C C    . GLY   A 1 46  ? -7.33711  -12.70008 3.87357   1.000 48.16113  ? 408 GLY   A C    1 
ATOM   651  O O    . GLY   A 1 46  ? -8.04262  -11.82054 3.36050   1.000 41.64781  ? 408 GLY   A O    1 
ATOM   652  H H    . GLY   A 1 46  ? -6.30144  -13.72823 6.42363   1.000 57.27697  ? 408 GLY   A H    1 
ATOM   653  H HA2  . GLY   A 1 46  ? -6.97734  -11.84075 5.67821   1.000 60.39958  ? 408 GLY   A HA2  1 
ATOM   654  H HA3  . GLY   A 1 46  ? -5.73059  -11.78174 4.71044   1.000 60.39958  ? 408 GLY   A HA3  1 
ATOM   655  N N    . LYS   A 1 47  ? -7.33012  -13.94751 3.42731   1.000 54.04255  ? 409 LYS   A N    1 
ATOM   656  C CA   . LYS   A 1 47  ? -8.18508  -14.37885 2.32950   1.000 57.38028  ? 409 LYS   A CA   1 
ATOM   657  C C    . LYS   A 1 47  ? -9.60389  -14.55486 2.84871   1.000 54.90912  ? 409 LYS   A C    1 
ATOM   658  O O    . LYS   A 1 47  ? -9.85790  -15.44068 3.66996   1.000 54.04554  ? 409 LYS   A O    1 
ATOM   659  C CB   . LYS   A 1 47  ? -7.65755  -15.68048 1.74182   1.000 65.90781  ? 409 LYS   A CB   1 
ATOM   660  C CG   . LYS   A 1 47  ? -8.32055  -16.08930 0.44837   1.000 77.83218  ? 409 LYS   A CG   1 
ATOM   661  C CD   . LYS   A 1 47  ? -7.64096  -17.32699 -0.14615  1.000 108.83726 ? 409 LYS   A CD   1 
ATOM   662  C CE   . LYS   A 1 47  ? -8.26913  -18.64790 0.30778   1.000 89.53343  ? 409 LYS   A CE   1 
ATOM   663  N NZ   . LYS   A 1 47  ? -8.49735  -19.55509 -0.85598  1.000 95.35086  ? 409 LYS   A NZ   1 
ATOM   664  H H    . LYS   A 1 47  ? -6.83290  -14.57205 3.74719   1.000 64.86311  ? 409 LYS   A H    1 
ATOM   665  H HA   . LYS   A 1 47  ? -8.19198  -13.70141 1.63528   1.000 68.86840  ? 409 LYS   A HA   1 
ATOM   666  H HB2  . LYS   A 1 47  ? -6.70875  -15.57971 1.56709   1.000 79.10142  ? 409 LYS   A HB2  1 
ATOM   667  H HB3  . LYS   A 1 47  ? -7.80274  -16.39222 2.38466   1.000 79.10142  ? 409 LYS   A HB3  1 
ATOM   668  H HG2  . LYS   A 1 47  ? -9.25250  -16.30047 0.61500   1.000 93.41068  ? 409 LYS   A HG2  1 
ATOM   669  H HG3  . LYS   A 1 47  ? -8.25412  -15.36433 -0.19265  1.000 93.41068  ? 409 LYS   A HG3  1 
ATOM   670  H HD2  . LYS   A 1 47  ? -7.70500  -17.28557 -1.11315  1.000 130.61676 ? 409 LYS   A HD2  1 
ATOM   671  H HD3  . LYS   A 1 47  ? -6.70956  -17.33359 0.12467   1.000 130.61676 ? 409 LYS   A HD3  1 
ATOM   672  H HE2  . LYS   A 1 47  ? -7.67387  -19.09172 0.93195   1.000 107.45217 ? 409 LYS   A HE2  1 
ATOM   673  H HE3  . LYS   A 1 47  ? -9.12315  -18.47110 0.73237   1.000 107.45217 ? 409 LYS   A HE3  1 
ATOM   674  H HZ1  . LYS   A 1 47  ? -8.86173  -20.31868 -0.57982  1.000 114.43309 ? 409 LYS   A HZ1  1 
ATOM   675  H HZ2  . LYS   A 1 47  ? -9.04567  -19.16821 -1.44058  1.000 114.43309 ? 409 LYS   A HZ2  1 
ATOM   676  H HZ3  . LYS   A 1 47  ? -7.72423  -19.73322 -1.25928  1.000 114.43309 ? 409 LYS   A HZ3  1 
ATOM   677  N N    . TYR   A 1 48  ? -10.53111 -13.72615 2.36339   1.000 50.71462  ? 410 TYR   A N    1 
ATOM   678  C CA   . TYR   A 1 48  ? -11.93423 -13.80493 2.74734   1.000 51.27029  ? 410 TYR   A CA   1 
ATOM   679  C C    . TYR   A 1 48  ? -12.78230 -14.09761 1.52147   1.000 58.44780  ? 410 TYR   A C    1 
ATOM   680  O O    . TYR   A 1 48  ? -12.66809 -13.40630 0.50164   1.000 54.42679  ? 410 TYR   A O    1 
ATOM   681  C CB   . TYR   A 1 48  ? -12.42153 -12.51366 3.39198   1.000 49.83967  ? 410 TYR   A CB   1 
ATOM   682  C CG   . TYR   A 1 48  ? -12.01375 -12.35811 4.83021   1.000 51.04138  ? 410 TYR   A CG   1 
ATOM   683  C CD1  . TYR   A 1 48  ? -10.67099 -12.32564 5.18872   1.000 50.33606  ? 410 TYR   A CD1  1 
ATOM   684  C CD2  . TYR   A 1 48  ? -12.96541 -12.23582 5.83019   1.000 46.16953  ? 410 TYR   A CD2  1 
ATOM   685  C CE1  . TYR   A 1 48  ? -10.29165 -12.18226 6.49036   1.000 45.84547  ? 410 TYR   A CE1  1 
ATOM   686  C CE2  . TYR   A 1 48  ? -12.59236 -12.08714 7.13737   1.000 54.63909  ? 410 TYR   A CE2  1 
ATOM   687  C CZ   . TYR   A 1 48  ? -11.25193 -12.06258 7.46462   1.000 49.16095  ? 410 TYR   A CZ   1 
ATOM   688  O OH   . TYR   A 1 48  ? -10.87748 -11.91175 8.77369   1.000 59.05927  ? 410 TYR   A OH   1 
ATOM   689  H H    . TYR   A 1 48  ? -10.36382 -13.09897 1.79924   1.000 60.86960  ? 410 TYR   A H    1 
ATOM   690  H HA   . TYR   A 1 48  ? -12.03484 -14.52798 3.38606   1.000 61.53640  ? 410 TYR   A HA   1 
ATOM   691  H HB2  . TYR   A 1 48  ? -12.05635 -11.76255 2.89864   1.000 59.81966  ? 410 TYR   A HB2  1 
ATOM   692  H HB3  . TYR   A 1 48  ? -13.39067 -12.49448 3.35612   1.000 59.81966  ? 410 TYR   A HB3  1 
ATOM   693  H HD1  . TYR   A 1 48  ? -10.02003 -12.40308 4.52905   1.000 60.41532  ? 410 TYR   A HD1  1 
ATOM   694  H HD2  . TYR   A 1 48  ? -13.86866 -12.25510 5.60959   1.000 55.41549  ? 410 TYR   A HD2  1 
ATOM   695  H HE1  . TYR   A 1 48  ? -9.38975  -12.16564 6.71663   1.000 55.02662  ? 410 TYR   A HE1  1 
ATOM   696  H HE2  . TYR   A 1 48  ? -13.23785 -12.00310 7.80158   1.000 65.57896  ? 410 TYR   A HE2  1 
ATOM   697  H HH   . TYR   A 1 48  ? -11.51943 -12.10417 9.28013   1.000 70.88318  ? 410 TYR   A HH   1 
ATOM   698  N N    . VAL   A 1 49  ? -13.63925 -15.10735 1.63324   1.000 61.96958  ? 411 VAL   A N    1 
ATOM   699  C CA   . VAL   A 1 49  ? -14.57037 -15.47068 0.57561   1.000 63.60495  ? 411 VAL   A CA   1 
ATOM   700  C C    . VAL   A 1 49  ? -15.97021 -15.10005 1.02552   1.000 60.98130  ? 411 VAL   A C    1 
ATOM   701  O O    . VAL   A 1 49  ? -16.35120 -15.34399 2.17635   1.000 54.89122  ? 411 VAL   A O    1 
ATOM   702  C CB   . VAL   A 1 49  ? -14.50456 -16.96373 0.21058   1.000 68.21146  ? 411 VAL   A CB   1 
ATOM   703  C CG1  . VAL   A 1 49  ? -15.29327 -17.21078 -1.08314  1.000 60.00993  ? 411 VAL   A CG1  1 
ATOM   704  C CG2  . VAL   A 1 49  ? -13.05073 -17.41428 0.07106   1.000 84.17823  ? 411 VAL   A CG2  1 
ATOM   705  H H    . VAL   A 1 49  ? -13.69973 -15.60749 2.33023   1.000 74.37555  ? 411 VAL   A H    1 
ATOM   706  H HA   . VAL   A 1 49  ? -14.34100 -14.96396 -0.21908  1.000 76.33799  ? 411 VAL   A HA   1 
ATOM   707  H HB   . VAL   A 1 49  ? -14.90544 -17.49376 0.91717   1.000 81.86581  ? 411 VAL   A HB   1 
ATOM   708  H HG11 . VAL   A 1 49  ? -15.19768 -18.14170 -1.33840  1.000 72.02397  ? 411 VAL   A HG11 1 
ATOM   709  H HG12 . VAL   A 1 49  ? -16.22825 -17.00489 -0.92720  1.000 72.02397  ? 411 VAL   A HG12 1 
ATOM   710  H HG13 . VAL   A 1 49  ? -14.94062 -16.63822 -1.78222  1.000 72.02397  ? 411 VAL   A HG13 1 
ATOM   711  H HG21 . VAL   A 1 49  ? -13.03045 -18.29322 -0.33877  1.000 101.02593 ? 411 VAL   A HG21 1 
ATOM   712  H HG22 . VAL   A 1 49  ? -12.57515 -16.77846 -0.48612  1.000 101.02593 ? 411 VAL   A HG22 1 
ATOM   713  H HG23 . VAL   A 1 49  ? -12.64543 -17.45044 0.95159   1.000 101.02593 ? 411 VAL   A HG23 1 
ATOM   714  N N    . CYS   A 1 50  ? -16.72673 -14.49745 0.11532   1.000 65.45418  ? 412 CYS   A N    1 
ATOM   715  C CA   . CYS   A 1 50  ? -18.13723 -14.25422 0.36563   1.000 66.71306  ? 412 CYS   A CA   1 
ATOM   716  C C    . CYS   A 1 50  ? -18.85445 -15.58907 0.50377   1.000 68.30943  ? 412 CYS   A C    1 
ATOM   717  O O    . CYS   A 1 50  ? -18.67486 -16.48548 -0.32454  1.000 65.73080  ? 412 CYS   A O    1 
ATOM   718  C CB   . CYS   A 1 50  ? -18.73625 -13.43881 -0.77175  1.000 63.95572  ? 412 CYS   A CB   1 
ATOM   719  S SG   . CYS   A 1 50  ? -20.48333 -13.07874 -0.58523  1.000 62.62026  ? 412 CYS   A SG   1 
ATOM   720  H H    . CYS   A 1 50  ? -16.44765 -14.22197 -0.65008  1.000 78.55706  ? 412 CYS   A H    1 
ATOM   721  H HA   . CYS   A 1 50  ? -18.25292 -13.74611 1.18376   1.000 80.06773  ? 412 CYS   A HA   1 
ATOM   722  H HB2  . CYS   A 1 50  ? -18.26624 -12.59203 -0.82604  1.000 76.75892  ? 412 CYS   A HB2  1 
ATOM   723  H HB3  . CYS   A 1 50  ? -18.62521 -13.93349 -1.59871  1.000 76.75892  ? 412 CYS   A HB3  1 
ATOM   724  N N    . GLU   A 1 51  ? -19.64329 -15.72918 1.56592   1.000 67.94444  ? 413 GLU   A N    1 
ATOM   725  C CA   . GLU   A 1 51  ? -20.32479 -16.97523 1.88231   1.000 65.93818  ? 413 GLU   A CA   1 
ATOM   726  C C    . GLU   A 1 51  ? -21.82354 -16.82258 1.64846   1.000 73.77392  ? 413 GLU   A C    1 
ATOM   727  O O    . GLU   A 1 51  ? -22.34632 -15.71212 1.50839   1.000 72.95758  ? 413 GLU   A O    1 
ATOM   728  C CB   . GLU   A 1 51  ? -20.04195 -17.39369 3.32701   1.000 60.49875  ? 413 GLU   A CB   1 
ATOM   729  C CG   . GLU   A 1 51  ? -18.86917 -18.34060 3.46315   1.000 61.97563  ? 413 GLU   A CG   1 
ATOM   730  C CD   . GLU   A 1 51  ? -19.17805 -19.73725 2.98246   1.000 66.02840  ? 413 GLU   A CD   1 
ATOM   731  O OE1  . GLU   A 1 51  ? -20.26493 -19.93791 2.38388   1.000 64.99929  ? 413 GLU   A OE1  1 
ATOM   732  O OE2  . GLU   A 1 51  ? -18.33363 -20.63360 3.20422   1.000 64.72839  ? 413 GLU   A OE2  1 
ATOM   733  H H    . GLU   A 1 51  ? -19.80109 -15.09944 2.12995   1.000 81.54538  ? 413 GLU   A H    1 
ATOM   734  H HA   . GLU   A 1 51  ? -19.99934 -17.67839 1.29873   1.000 79.13787  ? 413 GLU   A HA   1 
ATOM   735  H HB2  . GLU   A 1 51  ? -19.84556 -16.60043 3.84957   1.000 72.61055  ? 413 GLU   A HB2  1 
ATOM   736  H HB3  . GLU   A 1 51  ? -20.82659 -17.83946 3.68274   1.000 72.61055  ? 413 GLU   A HB3  1 
ATOM   737  H HG2  . GLU   A 1 51  ? -18.12772 -18.00115 2.93787   1.000 74.38281  ? 413 GLU   A HG2  1 
ATOM   738  H HG3  . GLU   A 1 51  ? -18.61577 -18.39570 4.39785   1.000 74.38281  ? 413 GLU   A HG3  1 
ATOM   739  N N    . ALA   A 1 52  ? -22.51345 -17.96946 1.60894   1.000 76.32475  ? 414 ALA   A N    1 
ATOM   740  C CA   . ALA   A 1 52  ? -23.94266 -17.97482 1.29971   1.000 74.24917  ? 414 ALA   A CA   1 
ATOM   741  C C    . ALA   A 1 52  ? -24.73929 -17.14005 2.29601   1.000 72.76742  ? 414 ALA   A C    1 
ATOM   742  O O    . ALA   A 1 52  ? -25.71724 -16.48529 1.91500   1.000 71.05538  ? 414 ALA   A O    1 
ATOM   743  C CB   . ALA   A 1 52  ? -24.46281 -19.41470 1.26425   1.000 61.33853  ? 414 ALA   A CB   1 
ATOM   744  H H    . ALA   A 1 52  ? -22.17945 -18.74819 1.75603   1.000 91.60175  ? 414 ALA   A H    1 
ATOM   745  H HA   . ALA   A 1 52  ? -24.07479 -17.58702 0.42048   1.000 89.11106  ? 414 ALA   A HA   1 
ATOM   746  H HB1  . ALA   A 1 52  ? -25.40503 -19.40452 1.03401   1.000 73.61829  ? 414 ALA   A HB1  1 
ATOM   747  H HB2  . ALA   A 1 52  ? -23.96491 -19.91403 0.59816   1.000 73.61829  ? 414 ALA   A HB2  1 
ATOM   748  H HB3  . ALA   A 1 52  ? -24.34028 -19.81636 2.13864   1.000 73.61829  ? 414 ALA   A HB3  1 
ATOM   749  N N    . ASP   A 1 53  ? -24.31311 -17.11262 3.56526   1.000 77.40233  ? 415 ASP   A N    1 
ATOM   750  C CA   . ASP   A 1 53  ? -24.97002 -16.28059 4.57018   1.000 77.10304  ? 415 ASP   A CA   1 
ATOM   751  C C    . ASP   A 1 53  ? -24.80560 -14.77889 4.32507   1.000 73.02506  ? 415 ASP   A C    1 
ATOM   752  O O    . ASP   A 1 53  ? -25.41297 -13.98745 5.05418   1.000 63.33078  ? 415 ASP   A O    1 
ATOM   753  C CB   . ASP   A 1 53  ? -24.46120 -16.62046 5.98414   1.000 81.58015  ? 415 ASP   A CB   1 
ATOM   754  C CG   . ASP   A 1 53  ? -22.94108 -16.68470 6.08425   1.000 76.51250  ? 415 ASP   A CG   1 
ATOM   755  O OD1  . ASP   A 1 53  ? -22.27930 -15.62045 6.06971   1.000 69.79023  ? 415 ASP   A OD1  1 
ATOM   756  O OD2  . ASP   A 1 53  ? -22.41977 -17.81260 6.21676   1.000 69.33399  ? 415 ASP   A OD2  1 
ATOM   757  H H    . ASP   A 1 53  ? -23.64721 -17.56672 3.86522   1.000 92.89485  ? 415 ASP   A H    1 
ATOM   758  H HA   . ASP   A 1 53  ? -25.91747 -16.48572 4.53605   1.000 92.53570  ? 415 ASP   A HA   1 
ATOM   759  H HB2  . ASP   A 1 53  ? -24.77066 -15.93856 6.60071   1.000 97.90823  ? 415 ASP   A HB2  1 
ATOM   760  H HB3  . ASP   A 1 53  ? -24.81256 -17.48653 6.24370   1.000 97.90823  ? 415 ASP   A HB3  1 
ATOM   761  N N    . GLY   A 1 54  ? -24.01466 -14.36481 3.33613   1.000 72.62180  ? 416 GLY   A N    1 
ATOM   762  C CA   . GLY   A 1 54  ? -23.90300 -12.96189 2.98841   1.000 78.29128  ? 416 GLY   A CA   1 
ATOM   763  C C    . GLY   A 1 54  ? -22.87788 -12.17561 3.77307   1.000 86.15845  ? 416 GLY   A C    1 
ATOM   764  O O    . GLY   A 1 54  ? -22.99695 -10.94437 3.85418   1.000 83.94503  ? 416 GLY   A O    1 
ATOM   765  H H    . GLY   A 1 54  ? -23.53115 -14.88517 2.85131   1.000 87.15821  ? 416 GLY   A H    1 
ATOM   766  H HA2  . GLY   A 1 54  ? -23.66761 -12.89517 2.04977   1.000 93.96158  ? 416 GLY   A HA2  1 
ATOM   767  H HA3  . GLY   A 1 54  ? -24.76536 -12.54044 3.12846   1.000 93.96158  ? 416 GLY   A HA3  1 
ATOM   768  N N    . PHE   A 1 55  ? -21.86214 -12.83995 4.33352   1.000 77.99812  ? 417 PHE   A N    1 
ATOM   769  C CA   . PHE   A 1 55  ? -20.86075 -12.20112 5.17886   1.000 70.07094  ? 417 PHE   A CA   1 
ATOM   770  C C    . PHE   A 1 55  ? -19.47817 -12.67647 4.76334   1.000 62.88449  ? 417 PHE   A C    1 
ATOM   771  O O    . PHE   A 1 55  ? -19.25797 -13.88226 4.59435   1.000 61.52743  ? 417 PHE   A O    1 
ATOM   772  C CB   . PHE   A 1 55  ? -21.09818 -12.51764 6.66523   1.000 64.82687  ? 417 PHE   A CB   1 
ATOM   773  H H    . PHE   A 1 55  ? -21.73245 -13.68417 4.23321   1.000 93.60980  ? 417 PHE   A H    1 
ATOM   774  H HA   . PHE   A 1 55  ? -20.90649 -11.23980 5.05772   1.000 84.09718  ? 417 PHE   A HA   1 
ATOM   775  N N    . TRP   A 1 56  ? -18.55594 -11.72724 4.60294   1.000 57.71184  ? 418 TRP   A N    1 
ATOM   776  C CA   . TRP   A 1 56  ? -17.17927 -12.05927 4.26156   1.000 51.99563  ? 418 TRP   A CA   1 
ATOM   777  C C    . TRP   A 1 56  ? -16.58848 -12.95663 5.33478   1.000 53.40837  ? 418 TRP   A C    1 
ATOM   778  O O    . TRP   A 1 56  ? -16.67623 -12.64970 6.52612   1.000 56.67213  ? 418 TRP   A O    1 
ATOM   779  C CB   . TRP   A 1 56  ? -16.35458 -10.78008 4.11621   1.000 50.53301  ? 418 TRP   A CB   1 
ATOM   780  C CG   . TRP   A 1 56  ? -16.65843 -10.01327 2.86935   1.000 51.30884  ? 418 TRP   A CG   1 
ATOM   781  C CD1  . TRP   A 1 56  ? -17.27751 -8.79419  2.77568   1.000 48.21604  ? 418 TRP   A CD1  1 
ATOM   782  C CD2  . TRP   A 1 56  ? -16.35852 -10.41103 1.52415   1.000 52.57916  ? 418 TRP   A CD2  1 
ATOM   783  N NE1  . TRP   A 1 56  ? -17.36879 -8.41468  1.46705   1.000 43.30117  ? 418 TRP   A NE1  1 
ATOM   784  C CE2  . TRP   A 1 56  ? -16.82455 -9.39048  0.67605   1.000 48.64808  ? 418 TRP   A CE2  1 
ATOM   785  C CE3  . TRP   A 1 56  ? -15.73698 -11.53029 0.95689   1.000 52.57194  ? 418 TRP   A CE3  1 
ATOM   786  C CZ2  . TRP   A 1 56  ? -16.69324 -9.45319  -0.70816  1.000 53.66302  ? 418 TRP   A CZ2  1 
ATOM   787  C CZ3  . TRP   A 1 56  ? -15.60513 -11.59043 -0.42032  1.000 54.10121  ? 418 TRP   A CZ3  1 
ATOM   788  C CH2  . TRP   A 1 56  ? -16.08498 -10.56282 -1.23674  1.000 53.56119  ? 418 TRP   A CH2  1 
ATOM   789  H H    . TRP   A 1 56  ? -18.70406 -10.88424 4.68673   1.000 69.26626  ? 418 TRP   A H    1 
ATOM   790  H HA   . TRP   A 1 56  ? -17.15120 -12.53020 3.41402   1.000 62.40681  ? 418 TRP   A HA   1 
ATOM   791  H HB2  . TRP   A 1 56  ? -16.53830 -10.20165 4.87290   1.000 60.65167  ? 418 TRP   A HB2  1 
ATOM   792  H HB3  . TRP   A 1 56  ? -15.41356 -11.01473 4.09877   1.000 60.65167  ? 418 TRP   A HB3  1 
ATOM   793  H HD1  . TRP   A 1 56  ? -17.58975 -8.29800  3.49763   1.000 57.87131  ? 418 TRP   A HD1  1 
ATOM   794  H HE1  . TRP   A 1 56  ? -17.71355 -7.67919  1.18459   1.000 51.97346  ? 418 TRP   A HE1  1 
ATOM   795  H HE3  . TRP   A 1 56  ? -15.41909 -12.21950 1.49431   1.000 63.09838  ? 418 TRP   A HE3  1 
ATOM   796  H HZ2  . TRP   A 1 56  ? -17.00621 -8.76839  -1.25404  1.000 64.40768  ? 418 TRP   A HZ2  1 
ATOM   797  H HZ3  . TRP   A 1 56  ? -15.19037 -12.32687 -0.80829  1.000 64.93351  ? 418 TRP   A HZ3  1 
ATOM   798  H HH2  . TRP   A 1 56  ? -15.98970 -10.63300 -2.15918  1.000 64.28548  ? 418 TRP   A HH2  1 
ATOM   799  N N    . THR   A 1 57  ? -15.99991 -14.07552 4.90926   1.000 52.73866  ? 419 THR   A N    1 
ATOM   800  C CA   . THR   A 1 57  ? -15.58974 -15.13568 5.81918   1.000 54.93824  ? 419 THR   A CA   1 
ATOM   801  C C    . THR   A 1 57  ? -14.24399 -15.70298 5.39915   1.000 53.61960  ? 419 THR   A C    1 
ATOM   802  O O    . THR   A 1 57  ? -13.95597 -15.81845 4.20734   1.000 52.86739  ? 419 THR   A O    1 
ATOM   803  C CB   . THR   A 1 57  ? -16.62915 -16.26494 5.86666   1.000 57.82487  ? 419 THR   A CB   1 
ATOM   804  O OG1  . THR   A 1 57  ? -17.94325 -15.70552 5.72681   1.000 59.36837  ? 419 THR   A OG1  1 
ATOM   805  C CG2  . THR   A 1 57  ? -16.52143 -17.01420 7.17330   1.000 59.44474  ? 419 THR   A CG2  1 
ATOM   806  H H    . THR   A 1 57  ? -15.82626 -14.24295 4.08378   1.000 63.29845  ? 419 THR   A H    1 
ATOM   807  H HA   . THR   A 1 57  ? -15.48939 -14.76149 6.70846   1.000 65.93794  ? 419 THR   A HA   1 
ATOM   808  H HB   . THR   A 1 57  ? -16.47438 -16.89393 5.14464   1.000 69.40190  ? 419 THR   A HB   1 
ATOM   809  H HG1  . THR   A 1 57  ? -18.51774 -16.31835 5.72559   1.000 71.25409  ? 419 THR   A HG1  1 
ATOM   810  H HG21 . THR   A 1 57  ? -17.18005 -17.72571 7.20301   1.000 71.34574  ? 419 THR   A HG21 1 
ATOM   811  H HG22 . THR   A 1 57  ? -15.63622 -17.40073 7.26209   1.000 71.34574  ? 419 THR   A HG22 1 
ATOM   812  H HG23 . THR   A 1 57  ? -16.67704 -16.40999 7.91601   1.000 71.34574  ? 419 THR   A HG23 1 
ATOM   813  N N    . SER   A 1 58  ? -13.43275 -16.07072 6.38837   1.000 52.13703  ? 420 SER   A N    1 
ATOM   814  C CA   . SER   A 1 58  ? -12.03554 -16.38987 6.15512   1.000 54.50857  ? 420 SER   A CA   1 
ATOM   815  C C    . SER   A 1 58  ? -11.85978 -17.88762 5.94864   1.000 53.36250  ? 420 SER   A C    1 
ATOM   816  O O    . SER   A 1 58  ? -12.80489 -18.66827 6.03617   1.000 52.19756  ? 420 SER   A O    1 
ATOM   817  C CB   . SER   A 1 58  ? -11.16994 -15.92121 7.32335   1.000 57.13816  ? 420 SER   A CB   1 
ATOM   818  O OG   . SER   A 1 58  ? -11.18533 -16.87537 8.37506   1.000 58.00560  ? 420 SER   A OG   1 
ATOM   819  H H    . SER   A 1 58  ? -13.67452 -16.14232 7.21057   1.000 62.57650  ? 420 SER   A H    1 
ATOM   820  H HA   . SER   A 1 58  ? -11.75640 -15.92393 5.35144   1.000 65.42234  ? 420 SER   A HA   1 
ATOM   821  H HB2  . SER   A 1 58  ? -10.25770 -15.80571 7.01454   1.000 68.57785  ? 420 SER   A HB2  1 
ATOM   822  H HB3  . SER   A 1 58  ? -11.51685 -15.07858 7.65580   1.000 68.57785  ? 420 SER   A HB3  1 
ATOM   823  H HG   . SER   A 1 58  ? -10.71007 -16.60689 9.01353   1.000 69.61877  ? 420 SER   A HG   1 
ATOM   824  N N    . SER   A 1 59  ? -10.61354 -18.29485 5.69952   1.000 57.60616  ? 421 SER   A N    1 
ATOM   825  C CA   . SER   A 1 59  ? -10.30447 -19.70960 5.52199   1.000 57.26809  ? 421 SER   A CA   1 
ATOM   826  C C    . SER   A 1 59  ? -10.54255 -20.52053 6.79098   1.000 57.06302  ? 421 SER   A C    1 
ATOM   827  O O    . SER   A 1 59  ? -10.61889 -21.75267 6.71904   1.000 59.68047  ? 421 SER   A O    1 
ATOM   828  C CB   . SER   A 1 59  ? -8.84750  -19.86789 5.06498   1.000 61.41693  ? 421 SER   A CB   1 
ATOM   829  O OG   . SER   A 1 59  ? -7.95449  -19.90093 6.17357   1.000 58.96341  ? 421 SER   A OG   1 
ATOM   830  H H    . SER   A 1 59  ? -9.93348  -17.77317 5.62913   1.000 69.13945  ? 421 SER   A H    1 
ATOM   831  H HA   . SER   A 1 59  ? -10.88146 -20.07043 4.83077   1.000 68.73376  ? 421 SER   A HA   1 
ATOM   832  H HB2  . SER   A 1 59  ? -8.76290  -20.69760 4.56969   1.000 73.71237  ? 421 SER   A HB2  1 
ATOM   833  H HB3  . SER   A 1 59  ? -8.61403  -19.11711 4.49689   1.000 73.71237  ? 421 SER   A HB3  1 
ATOM   834  H HG   . SER   A 1 59  ? -7.16921  -20.03273 5.90608   1.000 70.76815  ? 421 SER   A HG   1 
ATOM   835  N N    . LYS   A 1 60  ? -10.65111 -19.86041 7.94454   1.000 59.73901  ? 422 LYS   A N    1 
ATOM   836  C CA   . LYS   A 1 60  ? -10.91065 -20.50237 9.22656   1.000 59.87488  ? 422 LYS   A CA   1 
ATOM   837  C C    . LYS   A 1 60  ? -12.36484 -20.37918 9.67109   1.000 61.26254  ? 422 LYS   A C    1 
ATOM   838  O O    . LYS   A 1 60  ? -12.71451 -20.89836 10.73509  1.000 66.10209  ? 422 LYS   A O    1 
ATOM   839  C CB   . LYS   A 1 60  ? -9.98889  -19.89866 10.30307  1.000 60.59846  ? 422 LYS   A CB   1 
ATOM   840  C CG   . LYS   A 1 60  ? -8.51769  -20.32573 10.17169  1.000 58.74767  ? 422 LYS   A CG   1 
ATOM   841  C CD   . LYS   A 1 60  ? -7.49564  -19.17150 10.30285  1.000 59.43919  ? 422 LYS   A CD   1 
ATOM   842  C CE   . LYS   A 1 60  ? -6.29653  -19.36301 9.34671   1.000 67.62586  ? 422 LYS   A CE   1 
ATOM   843  N NZ   . LYS   A 1 60  ? -6.46628  -18.69822 7.99802   1.000 70.61851  ? 422 LYS   A NZ   1 
ATOM   844  H H    . LYS   A 1 60  ? -10.57474 -19.00628 8.00954   1.000 71.69886  ? 422 LYS   A H    1 
ATOM   845  H HA   . LYS   A 1 60  ? -10.70860 -21.44788 9.14849   1.000 71.86191  ? 422 LYS   A HA   1 
ATOM   846  H HB2  . LYS   A 1 60  ? -10.02334 -18.93159 10.23601  1.000 72.73021  ? 422 LYS   A HB2  1 
ATOM   847  H HB3  . LYS   A 1 60  ? -10.30237 -20.18204 11.17619  1.000 72.73021  ? 422 LYS   A HB3  1 
ATOM   848  H HG2  . LYS   A 1 60  ? -8.31967  -20.97073 10.86859  1.000 70.50926  ? 422 LYS   A HG2  1 
ATOM   849  H HG3  . LYS   A 1 60  ? -8.38998  -20.73016 9.29932   1.000 70.50926  ? 422 LYS   A HG3  1 
ATOM   850  H HD2  . LYS   A 1 60  ? -7.92934  -18.33214 10.08313  1.000 71.33909  ? 422 LYS   A HD2  1 
ATOM   851  H HD3  . LYS   A 1 60  ? -7.15869  -19.14280 11.21199  1.000 71.33909  ? 422 LYS   A HD3  1 
ATOM   852  H HE2  . LYS   A 1 60  ? -5.50480  -18.98665 9.76193   1.000 81.16308  ? 422 LYS   A HE2  1 
ATOM   853  H HE3  . LYS   A 1 60  ? -6.17073  -20.31234 9.19230   1.000 81.16308  ? 422 LYS   A HE3  1 
ATOM   854  H HZ1  . LYS   A 1 60  ? -5.78435  -18.90944 7.46655   1.000 84.75426  ? 422 LYS   A HZ1  1 
ATOM   855  H HZ2  . LYS   A 1 60  ? -7.22372  -18.97002 7.61785   1.000 84.75426  ? 422 LYS   A HZ2  1 
ATOM   856  H HZ3  . LYS   A 1 60  ? -6.49323  -17.81401 8.09572   1.000 84.75426  ? 422 LYS   A HZ3  1 
ATOM   857  N N    . GLY   A 1 61  ? -13.21775 -19.70613 8.89234   1.000 61.28087  ? 423 GLY   A N    1 
ATOM   858  C CA   . GLY   A 1 61  ? -14.60546 -19.49002 9.26435   1.000 55.26101  ? 423 GLY   A CA   1 
ATOM   859  C C    . GLY   A 1 61  ? -14.89226 -18.19335 9.99057   1.000 59.60532  ? 423 GLY   A C    1 
ATOM   860  O O    . GLY   A 1 61  ? -16.06140 -17.92174 10.30313  1.000 53.18187  ? 423 GLY   A O    1 
ATOM   861  H H    . GLY   A 1 61  ? -13.00670 -19.36209 8.13294   1.000 73.54910  ? 423 GLY   A H    1 
ATOM   862  H HA2  . GLY   A 1 61  ? -15.14529 -19.49997 8.45850   1.000 66.32526  ? 423 GLY   A HA2  1 
ATOM   863  H HA3  . GLY   A 1 61  ? -14.88624 -20.21727 9.84155   1.000 66.32526  ? 423 GLY   A HA3  1 
ATOM   864  N N    . GLU   A 1 62  ? -13.86816 -17.38928 10.27601  1.000 63.31424  ? 424 GLU   A N    1 
ATOM   865  C CA   . GLU   A 1 62  ? -14.06266 -16.11553 10.95209  1.000 63.44854  ? 424 GLU   A CA   1 
ATOM   866  C C    . GLU   A 1 62  ? -14.81498 -15.14674 10.05029  1.000 60.32000  ? 424 GLU   A C    1 
ATOM   867  O O    . GLU   A 1 62  ? -14.53281 -15.04332 8.85434   1.000 60.92886  ? 424 GLU   A O    1 
ATOM   868  C CB   . GLU   A 1 62  ? -12.70783 -15.50914 11.34763  1.000 61.60995  ? 424 GLU   A CB   1 
ATOM   869  C CG   . GLU   A 1 62  ? -11.95517 -16.27369 12.45833  1.000 67.13470  ? 424 GLU   A CG   1 
ATOM   870  C CD   . GLU   A 1 62  ? -10.52468 -16.67344 12.08243  1.000 71.11670  ? 424 GLU   A CD   1 
ATOM   871  O OE1  . GLU   A 1 62  ? -9.90090  -15.99766 11.24295  1.000 70.42626  ? 424 GLU   A OE1  1 
ATOM   872  O OE2  . GLU   A 1 62  ? -10.01252 -17.66994 12.63681  1.000 76.84956  ? 424 GLU   A OE2  1 
ATOM   873  H H    . GLU   A 1 62  ? -13.04728 -17.56194 10.08644  1.000 75.98914  ? 424 GLU   A H    1 
ATOM   874  H HA   . GLU   A 1 62  ? -14.58232 -16.25591 11.75903  1.000 76.15031  ? 424 GLU   A HA   1 
ATOM   875  H HB2  . GLU   A 1 62  ? -12.13621 -15.49569 10.56406  1.000 73.94399  ? 424 GLU   A HB2  1 
ATOM   876  H HB3  . GLU   A 1 62  ? -12.85648 -14.60480 11.66540  1.000 73.94399  ? 424 GLU   A HB3  1 
ATOM   877  H HG2  . GLU   A 1 62  ? -11.90583 -15.70942 13.24577  1.000 80.57370  ? 424 GLU   A HG2  1 
ATOM   878  H HG3  . GLU   A 1 62  ? -12.44385 -17.08631 12.66258  1.000 80.57370  ? 424 GLU   A HG3  1 
ATOM   879  N N    . LYS   A 1 63  ? -15.75808 -14.41622 10.63440  1.000 52.54882  ? 425 LYS   A N    1 
ATOM   880  C CA   . LYS   A 1 63  ? -16.52825 -13.41735 9.91318   1.000 54.73770  ? 425 LYS   A CA   1 
ATOM   881  C C    . LYS   A 1 63  ? -16.03611 -11.99730 10.15599  1.000 55.12267  ? 425 LYS   A C    1 
ATOM   882  O O    . LYS   A 1 63  ? -16.55161 -11.06893 9.53289   1.000 56.09161  ? 425 LYS   A O    1 
ATOM   883  C CB   . LYS   A 1 63  ? -18.01212 -13.49734 10.30367  1.000 66.80766  ? 425 LYS   A CB   1 
ATOM   884  C CG   . LYS   A 1 63  ? -18.66276 -14.88362 10.20931  1.000 69.25029  ? 425 LYS   A CG   1 
ATOM   885  C CD   . LYS   A 1 63  ? -19.44619 -15.08985 8.91551   1.000 66.24292  ? 425 LYS   A CD   1 
ATOM   886  C CE   . LYS   A 1 63  ? -20.05528 -16.48753 8.86459   1.000 63.49011  ? 425 LYS   A CE   1 
ATOM   887  N NZ   . LYS   A 1 63  ? -20.13318 -17.03692 7.48176   1.000 66.64812  ? 425 LYS   A NZ   1 
ATOM   888  H H    . LYS   A 1 63  ? -15.97261 -14.48413 11.46444  1.000 63.07064  ? 425 LYS   A H    1 
ATOM   889  H HA   . LYS   A 1 63  ? -16.45193 -13.61037 8.96565   1.000 65.69729  ? 425 LYS   A HA   1 
ATOM   890  H HB2  . LYS   A 1 63  ? -18.09899 -13.20289 11.22381  1.000 80.18125  ? 425 LYS   A HB2  1 
ATOM   891  H HB3  . LYS   A 1 63  ? -18.51124 -12.90690 9.71787   1.000 80.18125  ? 425 LYS   A HB3  1 
ATOM   892  H HG2  . LYS   A 1 63  ? -17.96936 -15.56074 10.24920  1.000 83.11241  ? 425 LYS   A HG2  1 
ATOM   893  H HG3  . LYS   A 1 63  ? -19.27776 -14.99444 10.95120  1.000 83.11241  ? 425 LYS   A HG3  1 
ATOM   894  H HD2  . LYS   A 1 63  ? -20.16426 -14.43967 8.86496   1.000 79.50356  ? 425 LYS   A HD2  1 
ATOM   895  H HD3  . LYS   A 1 63  ? -18.85082 -14.98625 8.15676   1.000 79.50356  ? 425 LYS   A HD3  1 
ATOM   896  H HE2  . LYS   A 1 63  ? -19.50968 -17.08911 9.39499   1.000 76.20019  ? 425 LYS   A HE2  1 
ATOM   897  H HE3  . LYS   A 1 63  ? -20.95572 -16.45270 9.22361   1.000 76.20019  ? 425 LYS   A HE3  1 
ATOM   898  H HZ1  . LYS   A 1 63  ? -20.73288 -17.69370 7.44848   1.000 79.98980  ? 425 LYS   A HZ1  1 
ATOM   899  H HZ2  . LYS   A 1 63  ? -20.37445 -16.39640 6.91288   1.000 79.98980  ? 425 LYS   A HZ2  1 
ATOM   900  H HZ3  . LYS   A 1 63  ? -19.33996 -17.35738 7.23640   1.000 79.98980  ? 425 LYS   A HZ3  1 
ATOM   901  N N    . SER   A 1 64  ? -15.06564 -11.80772 11.04649  1.000 59.13166  ? 426 SER   A N    1 
ATOM   902  C CA   . SER   A 1 64  ? -14.55225 -10.49579 11.41878  1.000 58.89275  ? 426 SER   A CA   1 
ATOM   903  C C    . SER   A 1 64  ? -13.14929 -10.29106 10.85714  1.000 55.31930  ? 426 SER   A C    1 
ATOM   904  O O    . SER   A 1 64  ? -12.53012 -11.20754 10.30777  1.000 49.54084  ? 426 SER   A O    1 
ATOM   905  C CB   . SER   A 1 64  ? -14.53917 -10.35007 12.94104  1.000 53.02878  ? 426 SER   A CB   1 
ATOM   906  O OG   . SER   A 1 64  ? -13.85372 -11.44868 13.50823  1.000 52.93847  ? 426 SER   A OG   1 
ATOM   907  H H    . SER   A 1 64  ? -14.67490 -12.45029 11.46365  1.000 70.97005  ? 426 SER   A H    1 
ATOM   908  H HA   . SER   A 1 64  ? -15.12517 -9.80925  11.04284  1.000 70.68335  ? 426 SER   A HA   1 
ATOM   909  H HB2  . SER   A 1 64  ? -14.08483 -9.52764  13.18204  1.000 63.64659  ? 426 SER   A HB2  1 
ATOM   910  H HB3  . SER   A 1 64  ? -15.45119 -10.33422 13.27100  1.000 63.64659  ? 426 SER   A HB3  1 
ATOM   911  H HG   . SER   A 1 64  ? -13.80674 -11.35856 14.34206  1.000 63.53822  ? 426 SER   A HG   1 
ATOM   912  N N    . LEU   A 1 65  ? -12.64867 -9.06389  11.01931  1.000 50.22814  ? 427 LEU   A N    1 
ATOM   913  C CA   . LEU   A 1 65  ? -11.40736 -8.65111  10.38516  1.000 51.54644  ? 427 LEU   A CA   1 
ATOM   914  C C    . LEU   A 1 65  ? -10.20076 -9.38674  10.97508  1.000 48.93747  ? 427 LEU   A C    1 
ATOM   915  O O    . LEU   A 1 65  ? -10.25727 -9.89445  12.09605  1.000 48.91721  ? 427 LEU   A O    1 
ATOM   916  C CB   . LEU   A 1 65  ? -11.20296 -7.14772  10.55896  1.000 55.99777  ? 427 LEU   A CB   1 
ATOM   917  C CG   . LEU   A 1 65  ? -11.95141 -6.15347  9.67396   1.000 60.74159  ? 427 LEU   A CG   1 
ATOM   918  C CD1  . LEU   A 1 65  ? -11.63373 -4.73927  10.12527  1.000 60.13077  ? 427 LEU   A CD1  1 
ATOM   919  C CD2  . LEU   A 1 65  ? -11.58734 -6.31243  8.22380   1.000 51.08152  ? 427 LEU   A CD2  1 
ATOM   920  H H    . LEU   A 1 65  ? -13.01568 -8.44995  11.49679  1.000 60.28583  ? 427 LEU   A H    1 
ATOM   921  H HA   . LEU   A 1 65  ? -11.45939 -8.86456  9.44036   1.000 61.86778  ? 427 LEU   A HA   1 
ATOM   922  H HB2  . LEU   A 1 65  ? -11.44979 -6.93115  11.47169  1.000 67.20938  ? 427 LEU   A HB2  1 
ATOM   923  H HB3  . LEU   A 1 65  ? -10.25934 -6.97138  10.41972  1.000 67.20938  ? 427 LEU   A HB3  1 
ATOM   924  H HG   . LEU   A 1 65  ? -12.90303 -6.32252  9.75613   1.000 72.90196  ? 427 LEU   A HG   1 
ATOM   925  H HD11 . LEU   A 1 65  ? -12.15985 -4.11495  9.60152   1.000 72.16898  ? 427 LEU   A HD11 1 
ATOM   926  H HD12 . LEU   A 1 65  ? -11.85483 -4.65069  11.06557  1.000 72.16898  ? 427 LEU   A HD12 1 
ATOM   927  H HD13 . LEU   A 1 65  ? -10.68826 -4.56961  9.99037   1.000 72.16898  ? 427 LEU   A HD13 1 
ATOM   928  H HD21 . LEU   A 1 65  ? -12.05434 -5.63868  7.70527   1.000 61.30988  ? 427 LEU   A HD21 1 
ATOM   929  H HD22 . LEU   A 1 65  ? -10.62892 -6.20059  8.12472   1.000 61.30988  ? 427 LEU   A HD22 1 
ATOM   930  H HD23 . LEU   A 1 65  ? -11.84936 -7.19818  7.92767   1.000 61.30988  ? 427 LEU   A HD23 1 
ATOM   931  N N    . PRO   A 1 66  ? -9.07800  -9.45657  10.22979  1.000 44.55268  ? 428 PRO   A N    1 
ATOM   932  C CA   . PRO   A 1 66  ? -7.81617  -9.85894  10.86045  1.000 48.48015  ? 428 PRO   A CA   1 
ATOM   933  C C    . PRO   A 1 66  ? -7.27617  -8.69033  11.65695  1.000 44.87652  ? 428 PRO   A C    1 
ATOM   934  O O    . PRO   A 1 66  ? -7.93797  -7.64265  11.73141  1.000 42.45639  ? 428 PRO   A O    1 
ATOM   935  C CB   . PRO   A 1 66  ? -6.89954  -10.20069 9.67887   1.000 46.07199  ? 428 PRO   A CB   1 
ATOM   936  C CG   . PRO   A 1 66  ? -7.75215  -10.03551 8.43922   1.000 49.65179  ? 428 PRO   A CG   1 
ATOM   937  C CD   . PRO   A 1 66  ? -8.86613  -9.13269  8.80820   1.000 50.18137  ? 428 PRO   A CD   1 
ATOM   938  H HA   . PRO   A 1 66  ? -7.91252  -10.65710 11.40318  1.000 58.18824  ? 428 PRO   A HA   1 
ATOM   939  H HB2  . PRO   A 1 66  ? -6.14544  -9.59080  9.66237   1.000 55.29844  ? 428 PRO   A HB2  1 
ATOM   940  H HB3  . PRO   A 1 66  ? -6.58531  -11.11462 9.76187   1.000 55.29844  ? 428 PRO   A HB3  1 
ATOM   941  H HG2  . PRO   A 1 66  ? -7.21887  -9.64584  7.72881   1.000 59.59421  ? 428 PRO   A HG2  1 
ATOM   942  H HG3  . PRO   A 1 66  ? -8.09227  -10.90069 8.16232   1.000 59.59421  ? 428 PRO   A HG3  1 
ATOM   943  H HD2  . PRO   A 1 66  ? -8.61308  -8.20298  8.69639   1.000 60.22970  ? 428 PRO   A HD2  1 
ATOM   944  H HD3  . PRO   A 1 66  ? -9.65951  -9.32585  8.28461   1.000 60.22970  ? 428 PRO   A HD3  1 
ATOM   945  N N    . VAL   A 1 67  ? -6.07420  -8.82364  12.21216  1.000 38.94642  ? 429 VAL   A N    1 
ATOM   946  C CA   . VAL   A 1 67  ? -5.44467  -7.73076  12.94338  1.000 39.55672  ? 429 VAL   A CA   1 
ATOM   947  C C    . VAL   A 1 67  ? -4.05120  -7.51707  12.38589  1.000 37.65546  ? 429 VAL   A C    1 
ATOM   948  O O    . VAL   A 1 67  ? -3.30631  -8.47797  12.19219  1.000 38.09111  ? 429 VAL   A O    1 
ATOM   949  C CB   . VAL   A 1 67  ? -5.37132  -7.99892  14.45759  1.000 40.99002  ? 429 VAL   A CB   1 
ATOM   950  C CG1  . VAL   A 1 67  ? -4.72511  -6.78458  15.18596  1.000 40.33689  ? 429 VAL   A CG1  1 
ATOM   951  C CG2  . VAL   A 1 67  ? -6.74285  -8.28733  15.01387  1.000 30.97459  ? 429 VAL   A CG2  1 
ATOM   952  H H    . VAL   A 1 67  ? -5.60277  -9.54208  12.17759  1.000 46.74776  ? 429 VAL   A H    1 
ATOM   953  H HA   . VAL   A 1 67  ? -5.96620  -6.92520  12.80210  1.000 47.48011  ? 429 VAL   A HA   1 
ATOM   954  H HB   . VAL   A 1 67  ? -4.81732  -8.77958  14.61430  1.000 49.20007  ? 429 VAL   A HB   1 
ATOM   955  H HG11 . VAL   A 1 67  ? -4.87157  -6.87447  16.14061  1.000 48.41632  ? 429 VAL   A HG11 1 
ATOM   956  H HG12 . VAL   A 1 67  ? -3.77378  -6.77267  14.99693  1.000 48.41632  ? 429 VAL   A HG12 1 
ATOM   957  H HG13 . VAL   A 1 67  ? -5.13666  -5.96748  14.86366  1.000 48.41632  ? 429 VAL   A HG13 1 
ATOM   958  H HG21 . VAL   A 1 67  ? -6.68207  -8.36649  15.97872  1.000 37.18156  ? 429 VAL   A HG21 1 
ATOM   959  H HG22 . VAL   A 1 67  ? -7.33863  -7.55891  14.77862  1.000 37.18156  ? 429 VAL   A HG22 1 
ATOM   960  H HG23 . VAL   A 1 67  ? -7.06958  -9.11779  14.63377  1.000 37.18156  ? 429 VAL   A HG23 1 
ATOM   961  N N    . CYS   A 1 68  ? -3.70608  -6.26436  12.13602  1.000 35.21303  ? 430 CYS   A N    1 
ATOM   962  C CA   . CYS   A 1 68  ? -2.34585  -5.86772  11.80692  1.000 39.00705  ? 430 CYS   A CA   1 
ATOM   963  C C    . CYS   A 1 68  ? -1.69849  -5.41378  13.10760  1.000 45.14229  ? 430 CYS   A C    1 
ATOM   964  O O    . CYS   A 1 68  ? -1.92233  -4.28601  13.56219  1.000 38.91435  ? 430 CYS   A O    1 
ATOM   965  C CB   . CYS   A 1 68  ? -2.32347  -4.75672  10.77165  1.000 42.59678  ? 430 CYS   A CB   1 
ATOM   966  S SG   . CYS   A 1 68  ? -2.93064  -5.24527  9.16609   1.000 39.65990  ? 430 CYS   A SG   1 
ATOM   967  H H    . CYS   A 1 68  ? -4.25867  -5.60556  12.15131  1.000 42.26769  ? 430 CYS   A H    1 
ATOM   968  H HA   . CYS   A 1 68  ? -1.86474  -6.62595  11.44016  1.000 46.82051  ? 430 CYS   A HA   1 
ATOM   969  H HB2  . CYS   A 1 68  ? -2.87896  -4.02690  11.08740  1.000 51.12820  ? 430 CYS   A HB2  1 
ATOM   970  H HB3  . CYS   A 1 68  ? -1.40868  -4.45362  10.66124  1.000 51.12820  ? 430 CYS   A HB3  1 
ATOM   971  N N    . GLU   A 1 69  ? -0.90383  -6.29872  13.69638  1.000 35.96513  ? 431 GLU   A N    1 
ATOM   972  C CA   . GLU   A 1 69  ? -0.25719  -6.00949  14.97049  1.000 41.30595  ? 431 GLU   A CA   1 
ATOM   973  C C    . GLU   A 1 69  ? 1.15830   -5.51673  14.72124  1.000 36.34663  ? 431 GLU   A C    1 
ATOM   974  O O    . GLU   A 1 69  ? 1.89160   -6.15699  13.94926  1.000 33.88792  ? 431 GLU   A O    1 
ATOM   975  C CB   . GLU   A 1 69  ? -0.22281  -7.26321  15.84529  1.000 50.88885  ? 431 GLU   A CB   1 
ATOM   976  C CG   . GLU   A 1 69  ? 0.32265   -7.03653  17.24091  1.000 53.87729  ? 431 GLU   A CG   1 
ATOM   977  C CD   . GLU   A 1 69  ? 0.57793   -8.33550  17.96316  1.000 55.52979  ? 431 GLU   A CD   1 
ATOM   978  O OE1  . GLU   A 1 69  ? -0.40482  -8.93043  18.43952  1.000 67.47005  ? 431 GLU   A OE1  1 
ATOM   979  O OE2  . GLU   A 1 69  ? 1.75124   -8.74786  18.05476  1.000 68.30079  ? 431 GLU   A OE2  1 
ATOM   980  H H    . GLU   A 1 69  ? -0.72204  -7.07660  13.37785  1.000 43.17021  ? 431 GLU   A H    1 
ATOM   981  H HA   . GLU   A 1 69  ? -0.75040  -5.32089  15.44322  1.000 49.57919  ? 431 GLU   A HA   1 
ATOM   982  H HB2  . GLU   A 1 69  ? -1.12694  -7.60289  15.93500  1.000 61.07867  ? 431 GLU   A HB2  1 
ATOM   983  H HB3  . GLU   A 1 69  ? 0.33936   -7.92593  15.41439  1.000 61.07867  ? 431 GLU   A HB3  1 
ATOM   984  H HG2  . GLU   A 1 69  ? 1.16113   -6.55248  17.18136  1.000 64.66480  ? 431 GLU   A HG2  1 
ATOM   985  H HG3  . GLU   A 1 69  ? -0.32031  -6.52425  17.75577  1.000 64.66480  ? 431 GLU   A HG3  1 
ATOM   986  N N    . PRO   A 1 70  ? 1.61760   -4.43835  15.36287  1.000 34.71779  ? 432 PRO   A N    1 
ATOM   987  C CA   . PRO   A 1 70  ? 2.97669   -3.95746  15.07333  1.000 34.32319  ? 432 PRO   A CA   1 
ATOM   988  C C    . PRO   A 1 70  ? 4.04946   -4.92424  15.51569  1.000 31.79340  ? 432 PRO   A C    1 
ATOM   989  O O    . PRO   A 1 70  ? 3.93337   -5.58682  16.54886  1.000 29.76694  ? 432 PRO   A O    1 
ATOM   990  C CB   . PRO   A 1 70  ? 3.06500   -2.64898  15.86088  1.000 34.26120  ? 432 PRO   A CB   1 
ATOM   991  C CG   . PRO   A 1 70  ? 1.59117   -2.22489  16.03097  1.000 36.10880  ? 432 PRO   A CG   1 
ATOM   992  C CD   . PRO   A 1 70  ? 0.88595   -3.48606  16.22725  1.000 34.85773  ? 432 PRO   A CD   1 
ATOM   993  H HA   . PRO   A 1 70  ? 3.06926   -3.79308  14.12185  1.000 41.19988  ? 432 PRO   A HA   1 
ATOM   994  H HB2  . PRO   A 1 70  ? 3.48839   -2.80248  16.71999  1.000 41.12550  ? 432 PRO   A HB2  1 
ATOM   995  H HB3  . PRO   A 1 70  ? 3.56559   -1.98779  15.35774  1.000 41.12550  ? 432 PRO   A HB3  1 
ATOM   996  H HG2  . PRO   A 1 70  ? 1.49588   -1.64568  16.80320  1.000 43.34262  ? 432 PRO   A HG2  1 
ATOM   997  H HG3  . PRO   A 1 70  ? 1.27930   -1.76883  15.23370  1.000 43.34262  ? 432 PRO   A HG3  1 
ATOM   998  H HD2  . PRO   A 1 70  ? 0.92920   -3.76255  17.15600  1.000 41.84133  ? 432 PRO   A HD2  1 
ATOM   999  H HD3  . PRO   A 1 70  ? -0.03941  -3.40912  15.94675  1.000 41.84133  ? 432 PRO   A HD3  1 
ATOM   1000 N N    . VAL   A 1 71  ? 5.12448   -4.97719  14.73019  1.000 31.53168  ? 433 VAL   A N    1 
ATOM   1001 C CA   . VAL   A 1 71  ? 6.33316   -5.63987  15.19732  1.000 34.30899  ? 433 VAL   A CA   1 
ATOM   1002 C C    . VAL   A 1 71  ? 6.80895   -4.91436  16.45472  1.000 33.20971  ? 433 VAL   A C    1 
ATOM   1003 O O    . VAL   A 1 71  ? 6.61693   -3.70151  16.60828  1.000 33.17023  ? 433 VAL   A O    1 
ATOM   1004 C CB   . VAL   A 1 71  ? 7.41980   -5.64895  14.10712  1.000 37.11733  ? 433 VAL   A CB   1 
ATOM   1005 C CG1  . VAL   A 1 71  ? 7.96836   -4.25258  13.86190  1.000 39.05885  ? 433 VAL   A CG1  1 
ATOM   1006 C CG2  . VAL   A 1 71  ? 8.56026   -6.57760  14.49746  1.000 43.07295  ? 433 VAL   A CG2  1 
ATOM   1007 H H    . VAL   A 1 71  ? 5.17660   -4.64348  13.93929  1.000 37.85006  ? 433 VAL   A H    1 
ATOM   1008 H HA   . VAL   A 1 71  ? 6.14372   -6.56651  15.41262  1.000 41.18285  ? 433 VAL   A HA   1 
ATOM   1009 H HB   . VAL   A 1 71  ? 7.01387   -5.96813  13.28599  1.000 44.55285  ? 433 VAL   A HB   1 
ATOM   1010 H HG11 . VAL   A 1 71  ? 8.40132   -4.23125  12.99415  1.000 46.88268  ? 433 VAL   A HG11 1 
ATOM   1011 H HG12 . VAL   A 1 71  ? 7.23550   -3.61742  13.88161  1.000 46.88268  ? 433 VAL   A HG12 1 
ATOM   1012 H HG13 . VAL   A 1 71  ? 8.61013   -4.03881  14.55712  1.000 46.88268  ? 433 VAL   A HG13 1 
ATOM   1013 H HG21 . VAL   A 1 71  ? 9.20388   -6.60939  13.77245  1.000 51.69959  ? 433 VAL   A HG21 1 
ATOM   1014 H HG22 . VAL   A 1 71  ? 8.98374   -6.23723  15.30103  1.000 51.69959  ? 433 VAL   A HG22 1 
ATOM   1015 H HG23 . VAL   A 1 71  ? 8.20323   -7.46438  14.66195  1.000 51.69959  ? 433 VAL   A HG23 1 
ATOM   1016 N N    . CYS   A 1 72  ? 7.42460   -5.66087  17.36710  1.000 28.46448  ? 434 CYS   A N    1 
ATOM   1017 C CA   . CYS   A 1 72  ? 7.86098   -5.11133  18.63492  1.000 28.07711  ? 434 CYS   A CA   1 
ATOM   1018 C C    . CYS   A 1 72  ? 9.28201   -5.56840  18.93293  1.000 27.73202  ? 434 CYS   A C    1 
ATOM   1019 O O    . CYS   A 1 72  ? 9.73588   -6.61623  18.46549  1.000 33.19013  ? 434 CYS   A O    1 
ATOM   1020 C CB   . CYS   A 1 72  ? 6.92014   -5.54587  19.76143  1.000 31.46100  ? 434 CYS   A CB   1 
ATOM   1021 S SG   . CYS   A 1 72  ? 6.81993   -7.34381  20.03406  1.000 31.82435  ? 434 CYS   A SG   1 
ATOM   1022 H H    . CYS   A 1 72  ? 7.60026   -6.49696  17.26861  1.000 34.16943  ? 434 CYS   A H    1 
ATOM   1023 H HA   . CYS   A 1 72  ? 7.86902   -4.14243  18.58946  1.000 33.70458  ? 434 CYS   A HA   1 
ATOM   1024 H HB2  . CYS   A 1 72  ? 7.22647   -5.14321  20.58903  1.000 37.76525  ? 434 CYS   A HB2  1 
ATOM   1025 H HB3  . CYS   A 1 72  ? 6.02607   -5.23361  19.55160  1.000 37.76525  ? 434 CYS   A HB3  1 
ATOM   1026 N N    . GLY   A 1 73  ? 9.96647   -4.77801  19.74923  1.000 28.47934  ? 435 GLY   A N    1 
ATOM   1027 C CA   . GLY   A 1 73  ? 11.20793  -5.19828  20.38036  1.000 26.74641  ? 435 GLY   A CA   1 
ATOM   1028 C C    . GLY   A 1 73  ? 12.44095  -5.10245  19.51144  1.000 30.26246  ? 435 GLY   A C    1 
ATOM   1029 O O    . GLY   A 1 73  ? 13.46686  -5.72050  19.82025  1.000 26.87467  ? 435 GLY   A O    1 
ATOM   1030 H H    . GLY   A 1 73  ? 9.72873   -3.97830  19.95790  1.000 34.18726  ? 435 GLY   A H    1 
ATOM   1031 H HA2  . GLY   A 1 73  ? 11.35764  -4.64694  21.16427  1.000 32.10775  ? 435 GLY   A HA2  1 
ATOM   1032 H HA3  . GLY   A 1 73  ? 11.11541  -6.12315  20.65775  1.000 32.10775  ? 435 GLY   A HA3  1 
ATOM   1033 N N    . LEU   A 1 74  ? 12.36565  -4.35558  18.42138  1.000 27.99794  ? 436 LEU   A N    1 
ATOM   1034 C CA   . LEU   A 1 74  ? 13.52271  -4.15539  17.57699  1.000 31.77606  ? 436 LEU   A CA   1 
ATOM   1035 C C    . LEU   A 1 74  ? 14.35849  -3.03038  18.15504  1.000 33.48952  ? 436 LEU   A C    1 
ATOM   1036 O O    . LEU   A 1 74  ? 13.82878  -2.04042  18.68926  1.000 29.97342  ? 436 LEU   A O    1 
ATOM   1037 C CB   . LEU   A 1 74  ? 13.08282  -3.82821  16.14868  1.000 31.26737  ? 436 LEU   A CB   1 
ATOM   1038 C CG   . LEU   A 1 74  ? 12.15981  -4.87658  15.52030  1.000 32.12771  ? 436 LEU   A CG   1 
ATOM   1039 C CD1  . LEU   A 1 74  ? 11.70921  -4.41880  14.13708  1.000 44.81149  ? 436 LEU   A CD1  1 
ATOM   1040 C CD2  . LEU   A 1 74  ? 12.83140  -6.21856  15.44714  1.000 39.34194  ? 436 LEU   A CD2  1 
ATOM   1041 H H    . LEU   A 1 74  ? 11.65420  -3.95491  18.15138  1.000 33.60958  ? 436 LEU   A H    1 
ATOM   1042 H HA   . LEU   A 1 74  ? 14.06518  -4.95836  17.53379  1.000 38.14332  ? 436 LEU   A HA   1 
ATOM   1043 H HB2  . LEU   A 1 74  ? 12.60649  -2.98327  16.15748  1.000 37.53290  ? 436 LEU   A HB2  1 
ATOM   1044 H HB3  . LEU   A 1 74  ? 13.87270  -3.75797  15.59006  1.000 37.53290  ? 436 LEU   A HB3  1 
ATOM   1045 H HG   . LEU   A 1 74  ? 11.37393  -4.97830  16.07972  1.000 38.56531  ? 436 LEU   A HG   1 
ATOM   1046 H HD11 . LEU   A 1 74  ? 11.10137  -5.07877  13.76849  1.000 53.78584  ? 436 LEU   A HD11 1 
ATOM   1047 H HD12 . LEU   A 1 74  ? 11.25898  -3.56350  14.21862  1.000 53.78584  ? 436 LEU   A HD12 1 
ATOM   1048 H HD13 . LEU   A 1 74  ? 12.48738  -4.32976  13.56487  1.000 53.78584  ? 436 LEU   A HD13 1 
ATOM   1049 H HD21 . LEU   A 1 74  ? 12.31178  -6.80075  14.87099  1.000 47.22239  ? 436 LEU   A HD21 1 
ATOM   1050 H HD22 . LEU   A 1 74  ? 13.72408  -6.10562  15.08482  1.000 47.22239  ? 436 LEU   A HD22 1 
ATOM   1051 H HD23 . LEU   A 1 74  ? 12.88184  -6.59553  16.33946  1.000 47.22239  ? 436 LEU   A HD23 1 
ATOM   1052 N N    . SER   A 1 75  ? 15.66424  -3.19506  18.07053  1.000 35.21547  ? 437 SER   A N    1 
ATOM   1053 C CA   . SER   A 1 75  ? 16.59150  -2.21853  18.60516  1.000 30.36483  ? 437 SER   A CA   1 
ATOM   1054 C C    . SER   A 1 75  ? 17.81511  -2.15348  17.70918  1.000 37.38203  ? 437 SER   A C    1 
ATOM   1055 O O    . SER   A 1 75  ? 18.23736  -3.17057  17.15694  1.000 36.03193  ? 437 SER   A O    1 
ATOM   1056 C CB   . SER   A 1 75  ? 17.02841  -2.57054  20.03089  1.000 33.06058  ? 437 SER   A CB   1 
ATOM   1057 O OG   . SER   A 1 75  ? 17.89069  -1.56519  20.53588  1.000 31.04442  ? 437 SER   A OG   1 
ATOM   1058 H H    . SER   A 1 75  ? 16.04342  -3.87379  17.70290  1.000 42.27062  ? 437 SER   A H    1 
ATOM   1059 H HA   . SER   A 1 75  ? 16.16576  -1.34708  18.61990  1.000 36.44984  ? 437 SER   A HA   1 
ATOM   1060 H HB2  . SER   A 1 75  ? 16.24440  -2.63322  20.59861  1.000 39.68475  ? 437 SER   A HB2  1 
ATOM   1061 H HB3  . SER   A 1 75  ? 17.49895  -3.41871  20.02022  1.000 39.68475  ? 437 SER   A HB3  1 
ATOM   1062 H HG   . SER   A 1 75  ? 17.49744  -0.82293  20.53606  1.000 37.26535  ? 437 SER   A HG   1 
ATOM   1063 N N    . ALA   A 1 76  ? 18.37875  -0.93761  17.57991  1.000 35.17024  ? 438 ALA   A N    1 
ATOM   1064 C CA   . ALA   A 1 76  ? 19.62856  -0.73710  16.85443  1.000 33.02214  ? 438 ALA   A CA   1 
ATOM   1065 C C    . ALA   A 1 76  ? 20.84085  -1.21876  17.62682  1.000 38.24099  ? 438 ALA   A C    1 
ATOM   1066 O O    . ALA   A 1 76  ? 21.91149  -1.38226  17.02941  1.000 46.66033  ? 438 ALA   A O    1 
ATOM   1067 C CB   . ALA   A 1 76  ? 19.82554  0.74345   16.52187  1.000 37.35356  ? 438 ALA   A CB   1 
ATOM   1068 H H    . ALA   A 1 76  ? 18.04948  -0.21387  17.90761  1.000 42.21635  ? 438 ALA   A H    1 
ATOM   1069 H HA   . ALA   A 1 76  ? 19.56755  -1.23914  16.02670  1.000 39.63862  ? 438 ALA   A HA   1 
ATOM   1070 H HB1  . ALA   A 1 76  ? 20.65080  0.84797   16.02296  1.000 44.83633  ? 438 ALA   A HB1  1 
ATOM   1071 H HB2  . ALA   A 1 76  ? 19.07550  1.04982   15.98851  1.000 44.83633  ? 438 ALA   A HB2  1 
ATOM   1072 H HB3  . ALA   A 1 76  ? 19.87227  1.24923   17.34825  1.000 44.83633  ? 438 ALA   A HB3  1 
ATOM   1073 N N    . ARG   A 1 77  ? 20.71552  -1.42980  18.93825  1.000 35.56418  ? 439 ARG   A N    1 
ATOM   1074 C CA   . ARG   A 1 77  ? 21.76505  -2.14067  19.65706  1.000 47.81587  ? 439 ARG   A CA   1 
ATOM   1075 C C    . ARG   A 1 77  ? 21.88881  -3.57982  19.16499  1.000 46.87527  ? 439 ARG   A C    1 
ATOM   1076 O O    . ARG   A 1 77  ? 22.96349  -4.17919  19.26130  1.000 57.55240  ? 439 ARG   A O    1 
ATOM   1077 C CB   . ARG   A 1 77  ? 21.47447  -2.14106  21.15332  1.000 45.44946  ? 439 ARG   A CB   1 
ATOM   1078 C CG   . ARG   A 1 77  ? 21.38207  -0.78090  21.77512  1.000 43.98727  ? 439 ARG   A CG   1 
ATOM   1079 C CD   . ARG   A 1 77  ? 20.76395  -0.86671  23.15196  1.000 48.16888  ? 439 ARG   A CD   1 
ATOM   1080 N NE   . ARG   A 1 77  ? 21.70147  -1.38541  24.15032  1.000 50.42394  ? 439 ARG   A NE   1 
ATOM   1081 C CZ   . ARG   A 1 77  ? 21.35175  -1.94162  25.30574  1.000 44.00806  ? 439 ARG   A CZ   1 
ATOM   1082 N NH1  . ARG   A 1 77  ? 20.07320  -2.12451  25.63427  1.000 43.38321  ? 439 ARG   A NH1  1 
ATOM   1083 N NH2  . ARG   A 1 77  ? 22.30357  -2.31488  26.15703  1.000 41.13919  ? 439 ARG   A NH2  1 
ATOM   1084 H H    . ARG   A 1 77  ? 20.04960  -1.17748  19.42042  1.000 42.68907  ? 439 ARG   A H    1 
ATOM   1085 H HA   . ARG   A 1 77  ? 22.60677  -1.68167  19.50963  1.000 57.39110  ? 439 ARG   A HA   1 
ATOM   1086 H HB2  . ARG   A 1 77  ? 20.62664  -2.58820  21.30218  1.000 54.55141  ? 439 ARG   A HB2  1 
ATOM   1087 H HB3  . ARG   A 1 77  ? 22.18633  -2.62072  21.60507  1.000 54.55141  ? 439 ARG   A HB3  1 
ATOM   1088 H HG2  . ARG   A 1 77  ? 22.27066  -0.40102  21.85881  1.000 52.79677  ? 439 ARG   A HG2  1 
ATOM   1089 H HG3  . ARG   A 1 77  ? 20.82715  -0.20830  21.22276  1.000 52.79677  ? 439 ARG   A HG3  1 
ATOM   1090 H HD2  . ARG   A 1 77  ? 20.48535  0.01942   23.43135  1.000 57.81471  ? 439 ARG   A HD2  1 
ATOM   1091 H HD3  . ARG   A 1 77  ? 19.99777  -1.46073  23.12020  1.000 57.81471  ? 439 ARG   A HD3  1 
ATOM   1092 H HE   . ARG   A 1 77  ? 22.54147  -1.32563  23.97588  1.000 60.52079  ? 439 ARG   A HE   1 
ATOM   1093 H HH11 . ARG   A 1 77  ? 19.45101  -1.88046  25.09305  1.000 52.07190  ? 439 ARG   A HH11 1 
ATOM   1094 H HH12 . ARG   A 1 77  ? 19.87033  -2.48658  26.38750  1.000 52.07190  ? 439 ARG   A HH12 1 
ATOM   1095 H HH21 . ARG   A 1 77  ? 23.13117  -2.19505  25.95625  1.000 49.37908  ? 439 ARG   A HH21 1 
ATOM   1096 H HH22 . ARG   A 1 77  ? 22.09123  -2.67599  26.90811  1.000 49.37908  ? 439 ARG   A HH22 1 
ATOM   1097 N N    . THR   A 1 78  ? 20.79532  -4.13775  18.64555  1.000 50.47244  ? 440 THR   A N    1 
ATOM   1098 C CA   . THR   A 1 78  ? 20.72259  -5.50461  18.14974  1.000 55.33799  ? 440 THR   A CA   1 
ATOM   1099 C C    . THR   A 1 78  ? 20.34316  -5.51727  16.66938  1.000 61.05579  ? 440 THR   A C    1 
ATOM   1100 O O    . THR   A 1 78  ? 21.20057  -5.61466  15.79741  1.000 70.08255  ? 440 THR   A O    1 
ATOM   1101 C CB   . THR   A 1 78  ? 19.69051  -6.31397  18.95210  1.000 51.97647  ? 440 THR   A CB   1 
ATOM   1102 O OG1  . THR   A 1 78  ? 18.42930  -5.63170  18.95474  1.000 50.54359  ? 440 THR   A OG1  1 
ATOM   1103 C CG2  . THR   A 1 78  ? 20.16483  -6.48437  20.38197  1.000 47.34243  ? 440 THR   A CG2  1 
ATOM   1104 H H    . THR   A 1 78  ? 20.04663  -3.72200  18.56663  1.000 60.57899  ? 440 THR   A H    1 
ATOM   1105 H HA   . THR   A 1 78  ? 21.58552  -5.93871  18.23805  1.000 66.41765  ? 440 THR   A HA   1 
ATOM   1106 H HB   . THR   A 1 78  ? 19.57937  -7.18895  18.54841  1.000 62.38382  ? 440 THR   A HB   1 
ATOM   1107 H HG1  . THR   A 1 78  ? 18.11138  -5.61255  18.17747  1.000 60.66437  ? 440 THR   A HG1  1 
ATOM   1108 H HG21 . THR   A 1 78  ? 19.52926  -7.02135  20.88057  1.000 56.82297  ? 440 THR   A HG21 1 
ATOM   1109 H HG22 . THR   A 1 78  ? 21.02836  -6.92602  20.39465  1.000 56.82297  ? 440 THR   A HG22 1 
ATOM   1110 H HG23 . THR   A 1 78  ? 20.24824  -5.61761  20.80936  1.000 56.82297  ? 440 THR   A HG23 1 
ATOM   1111 N N    . ILE   A 1 83  ? 18.90187  8.65203   34.46801  1.000 23.70796  ? 445 ILE   A N    1 
ATOM   1112 C CA   . ILE   A 1 83  ? 19.80382  7.51453   34.42356  1.000 27.64613  ? 445 ILE   A CA   1 
ATOM   1113 C C    . ILE   A 1 83  ? 21.16240  7.90154   34.98804  1.000 28.97524  ? 445 ILE   A C    1 
ATOM   1114 O O    . ILE   A 1 83  ? 21.81962  8.81736   34.49434  1.000 28.84406  ? 445 ILE   A O    1 
ATOM   1115 C CB   . ILE   A 1 83  ? 19.94865  6.96442   32.99847  1.000 25.56032  ? 445 ILE   A CB   1 
ATOM   1116 C CG1  . ILE   A 1 83  ? 18.57422  6.60888   32.40048  1.000 29.50605  ? 445 ILE   A CG1  1 
ATOM   1117 C CG2  . ILE   A 1 83  ? 20.84946  5.75907   33.01317  1.000 31.69677  ? 445 ILE   A CG2  1 
ATOM   1118 C CD1  . ILE   A 1 83  ? 17.89834  5.41923   33.02438  1.000 26.85749  ? 445 ILE   A CD1  1 
ATOM   1119 H HA   . ILE   A 1 83  ? 19.43033  6.80815   34.97350  1.000 33.18741  ? 445 ILE   A HA   1 
ATOM   1120 H HB   . ILE   A 1 83  ? 20.34308  7.65242   32.43992  1.000 30.68444  ? 445 ILE   A HB   1 
ATOM   1121 H HG12 . ILE   A 1 83  ? 17.98416  7.37053   32.51279  1.000 35.41932  ? 445 ILE   A HG12 1 
ATOM   1122 H HG13 . ILE   A 1 83  ? 18.69051  6.41558   31.45708  1.000 35.41932  ? 445 ILE   A HG13 1 
ATOM   1123 H HG21 . ILE   A 1 83  ? 20.68587  5.23280   32.21493  1.000 38.04818  ? 445 ILE   A HG21 1 
ATOM   1124 H HG22 . ILE   A 1 83  ? 21.77298  6.05520   33.03063  1.000 38.04818  ? 445 ILE   A HG22 1 
ATOM   1125 H HG23 . ILE   A 1 83  ? 20.65664  5.23034   33.80322  1.000 38.04818  ? 445 ILE   A HG23 1 
ATOM   1126 H HD11 . ILE   A 1 83  ? 17.00281  5.33804   32.66060  1.000 32.24105  ? 445 ILE   A HD11 1 
ATOM   1127 H HD12 . ILE   A 1 83  ? 18.41161  4.62171   32.82086  1.000 32.24105  ? 445 ILE   A HD12 1 
ATOM   1128 H HD13 . ILE   A 1 83  ? 17.85479  5.54844   33.98475  1.000 32.24105  ? 445 ILE   A HD13 1 
ATOM   1129 N N    . TYR   A 1 84  ? 21.58514  7.18745   36.02041  1.000 29.16360  ? 446 TYR   A N    1 
ATOM   1130 C CA   . TYR   A 1 84  ? 22.86418  7.41911   36.69204  1.000 31.74484  ? 446 TYR   A CA   1 
ATOM   1131 C C    . TYR   A 1 84  ? 23.88281  6.42912   36.14157  1.000 32.82282  ? 446 TYR   A C    1 
ATOM   1132 O O    . TYR   A 1 84  ? 23.62115  5.23082   36.11337  1.000 34.40664  ? 446 TYR   A O    1 
ATOM   1133 C CB   . TYR   A 1 84  ? 22.68288  7.25876   38.20525  1.000 36.71669  ? 446 TYR   A CB   1 
ATOM   1134 C CG   . TYR   A 1 84  ? 23.84738  7.64171   39.10231  1.000 41.45778  ? 446 TYR   A CG   1 
ATOM   1135 C CD1  . TYR   A 1 84  ? 25.04798  6.93647   39.07890  1.000 44.16907  ? 446 TYR   A CD1  1 
ATOM   1136 C CD2  . TYR   A 1 84  ? 23.71311  8.65974   40.03285  1.000 41.47632  ? 446 TYR   A CD2  1 
ATOM   1137 C CE1  . TYR   A 1 84  ? 26.09135  7.27665   39.91303  1.000 44.79529  ? 446 TYR   A CE1  1 
ATOM   1138 C CE2  . TYR   A 1 84  ? 24.74787  8.99382   40.87960  1.000 44.63857  ? 446 TYR   A CE2  1 
ATOM   1139 C CZ   . TYR   A 1 84  ? 25.93149  8.30223   40.80611  1.000 45.35345  ? 446 TYR   A CZ   1 
ATOM   1140 O OH   . TYR   A 1 84  ? 26.95814  8.62789   41.63399  1.000 49.32627  ? 446 TYR   A OH   1 
ATOM   1141 H H    . TYR   A 1 84  ? 21.13639  6.53989   36.36521  1.000 35.00837  ? 446 TYR   A H    1 
ATOM   1142 H HA   . TYR   A 1 84  ? 23.19926  8.31376   36.52408  1.000 38.10586  ? 446 TYR   A HA   1 
ATOM   1143 H HB2  . TYR   A 1 84  ? 21.93131  7.81019   38.47354  1.000 44.07208  ? 446 TYR   A HB2  1 
ATOM   1144 H HB3  . TYR   A 1 84  ? 22.48944  6.32502   38.38303  1.000 44.07208  ? 446 TYR   A HB3  1 
ATOM   1145 H HD1  . TYR   A 1 84  ? 25.14758  6.22347   38.49016  1.000 53.01494  ? 446 TYR   A HD1  1 
ATOM   1146 H HD2  . TYR   A 1 84  ? 22.91021  9.12594   40.08693  1.000 49.78364  ? 446 TYR   A HD2  1 
ATOM   1147 H HE1  . TYR   A 1 84  ? 26.89676  6.81368   39.86962  1.000 53.76641  ? 446 TYR   A HE1  1 
ATOM   1148 H HE2  . TYR   A 1 84  ? 24.64510  9.68251   41.49607  1.000 53.57833  ? 446 TYR   A HE2  1 
ATOM   1149 H HH   . TYR   A 1 84  ? 26.74363  9.28327   42.11364  1.000 59.20358  ? 446 TYR   A HH   1 
ATOM   1150 N N    . GLY   A 1 85  ? 25.02618  6.92689   35.68470  1.000 32.90250  ? 447 GLY   A N    1 
ATOM   1151 C CA   . GLY   A 1 85  ? 26.08848  6.04184   35.23309  1.000 33.93292  ? 447 GLY   A CA   1 
ATOM   1152 C C    . GLY   A 1 85  ? 25.85480  5.42779   33.87740  1.000 32.89551  ? 447 GLY   A C    1 
ATOM   1153 O O    . GLY   A 1 85  ? 26.35976  4.33982   33.59572  1.000 38.18324  ? 447 GLY   A O    1 
ATOM   1154 H H    . GLY   A 1 85  ? 25.20906  7.76523   35.62691  1.000 39.49505  ? 447 GLY   A H    1 
ATOM   1155 H HA2  . GLY   A 1 85  ? 26.91744  6.54396   35.19326  1.000 40.73156  ? 447 GLY   A HA2  1 
ATOM   1156 H HA3  . GLY   A 1 85  ? 26.18694  5.32002   35.87354  1.000 40.73156  ? 447 GLY   A HA3  1 
ATOM   1157 N N    . GLY   A 1 86  ? 25.11454  6.11227   33.01468  1.000 37.68927  ? 448 GLY   A N    1 
ATOM   1158 C CA   . GLY   A 1 86  ? 24.75307  5.59391   31.72389  1.000 38.66423  ? 448 GLY   A CA   1 
ATOM   1159 C C    . GLY   A 1 86  ? 25.42980  6.32629   30.58626  1.000 34.65325  ? 448 GLY   A C    1 
ATOM   1160 O O    . GLY   A 1 86  ? 26.29807  7.18447   30.76799  1.000 40.87514  ? 448 GLY   A O    1 
ATOM   1161 H H    . GLY   A 1 86  ? 24.80596  6.90028   33.16774  1.000 45.23918  ? 448 GLY   A H    1 
ATOM   1162 H HA2  . GLY   A 1 86  ? 25.00334  4.65807   31.67426  1.000 46.40913  ? 448 GLY   A HA2  1 
ATOM   1163 H HA3  . GLY   A 1 86  ? 23.79328  5.67080   31.60642  1.000 46.40913  ? 448 GLY   A HA3  1 
ATOM   1164 N N    . GLN   A 1 87  ? 25.02528  5.95618   29.39543  1.000 32.86161  ? 449 GLN   A N    1 
ATOM   1165 C CA   . GLN   A 1 87  ? 25.57958  6.51341   28.18214  1.000 34.65338  ? 449 GLN   A CA   1 
ATOM   1166 C C    . GLN   A 1 87  ? 24.43785  6.89421   27.26858  1.000 33.81605  ? 449 GLN   A C    1 
ATOM   1167 O O    . GLN   A 1 87  ? 23.29862  6.43861   27.42514  1.000 29.45679  ? 449 GLN   A O    1 
ATOM   1168 C CB   . GLN   A 1 87  ? 26.53537  5.54130   27.49620  1.000 33.56571  ? 449 GLN   A CB   1 
ATOM   1169 C CG   . GLN   A 1 87  ? 25.96296  4.58477   26.53382  1.000 43.67341  ? 449 GLN   A CG   1 
ATOM   1170 C CD   . GLN   A 1 87  ? 27.01985  3.61064   26.07245  1.000 53.71391  ? 449 GLN   A CD   1 
ATOM   1171 O OE1  . GLN   A 1 87  ? 27.50896  2.81576   26.86772  1.000 51.57420  ? 449 GLN   A OE1  1 
ATOM   1172 N NE2  . GLN   A 1 87  ? 27.38182  3.66815   24.79124  1.000 63.44401  ? 449 GLN   A NE2  1 
ATOM   1173 H H    . GLN   A 1 87  ? 24.41377  5.36744   29.25745  1.000 39.44599  ? 449 GLN   A H    1 
ATOM   1174 H HA   . GLN   A 1 87  ? 26.08986  7.31417   28.38037  1.000 41.59610  ? 449 GLN   A HA   1 
ATOM   1175 H HB2  . GLN   A 1 87  ? 27.19361  6.06427   27.01236  1.000 40.29091  ? 449 GLN   A HB2  1 
ATOM   1176 H HB3  . GLN   A 1 87  ? 26.97057  5.01664   28.18630  1.000 40.29091  ? 449 GLN   A HB3  1 
ATOM   1177 H HG2  . GLN   A 1 87  ? 25.24575  4.08718   26.95682  1.000 52.42014  ? 449 GLN   A HG2  1 
ATOM   1178 H HG3  . GLN   A 1 87  ? 25.62388  5.06362   25.76141  1.000 52.42014  ? 449 GLN   A HG3  1 
ATOM   1179 H HE21 . GLN   A 1 87  ? 27.01636  4.24326   24.26656  1.000 76.14486  ? 449 GLN   A HE21 1 
ATOM   1180 H HE22 . GLN   A 1 87  ? 27.98088  3.13016   24.48910  1.000 76.14486  ? 449 GLN   A HE22 1 
ATOM   1181 N N    . LYS   A 1 88  ? 24.77348  7.75047   26.32039  1.000 31.80088  ? 450 LYS   A N    1 
ATOM   1182 C CA   . LYS   A 1 88  ? 23.76290  8.35171   25.48234  1.000 34.50350  ? 450 LYS   A CA   1 
ATOM   1183 C C    . LYS   A 1 88  ? 23.24617  7.33310   24.48723  1.000 28.11490  ? 450 LYS   A C    1 
ATOM   1184 O O    . LYS   A 1 88  ? 24.00469  6.77588   23.69350  1.000 29.20908  ? 450 LYS   A O    1 
ATOM   1185 C CB   . LYS   A 1 88  ? 24.29966  9.57117   24.74695  1.000 31.25728  ? 450 LYS   A CB   1 
ATOM   1186 C CG   . LYS   A 1 88  ? 23.15655  10.34033  24.08787  1.000 29.81203  ? 450 LYS   A CG   1 
ATOM   1187 C CD   . LYS   A 1 88  ? 23.59152  11.72854  23.61958  1.000 36.15062  ? 450 LYS   A CD   1 
ATOM   1188 C CE   . LYS   A 1 88  ? 24.60280  11.64911  22.51221  1.000 37.37707  ? 450 LYS   A CE   1 
ATOM   1189 N NZ   . LYS   A 1 88  ? 24.62929  12.97456  21.76271  1.000 44.77762  ? 450 LYS   A NZ   1 
ATOM   1190 H H    . LYS   A 1 88  ? 25.57829  7.99750   26.14470  1.000 38.17311  ? 450 LYS   A H    1 
ATOM   1191 H HA   . LYS   A 1 88  ? 23.03366  8.64566   26.05041  1.000 41.41625  ? 450 LYS   A HA   1 
ATOM   1192 H HB2  . LYS   A 1 88  ? 24.74720  10.15872  25.37575  1.000 37.52079  ? 450 LYS   A HB2  1 
ATOM   1193 H HB3  . LYS   A 1 88  ? 24.92084  9.28763   24.05800  1.000 37.52079  ? 450 LYS   A HB3  1 
ATOM   1194 H HG2  . LYS   A 1 88  ? 22.84290  9.84519   23.31498  1.000 35.78649  ? 450 LYS   A HG2  1 
ATOM   1195 H HG3  . LYS   A 1 88  ? 22.43520  10.44932  24.72715  1.000 35.78649  ? 450 LYS   A HG3  1 
ATOM   1196 H HD2  . LYS   A 1 88  ? 22.81807  12.21292  23.29084  1.000 43.39279  ? 450 LYS   A HD2  1 
ATOM   1197 H HD3  . LYS   A 1 88  ? 23.99131  12.20689  24.36271  1.000 43.39279  ? 450 LYS   A HD3  1 
ATOM   1198 H HE2  . LYS   A 1 88  ? 25.48348  11.47860  22.88129  1.000 44.86454  ? 450 LYS   A HE2  1 
ATOM   1199 H HE3  . LYS   A 1 88  ? 24.35985  10.94256  21.89361  1.000 44.86454  ? 450 LYS   A HE3  1 
ATOM   1200 H HZ1  . LYS   A 1 88  ? 25.24780  12.95033  21.12321  1.000 53.74520  ? 450 LYS   A HZ1  1 
ATOM   1201 H HZ2  . LYS   A 1 88  ? 23.83564  13.13009  21.39119  1.000 53.74520  ? 450 LYS   A HZ2  1 
ATOM   1202 H HZ3  . LYS   A 1 88  ? 24.82032  13.63805  22.32430  1.000 53.74520  ? 450 LYS   A HZ3  1 
ATOM   1203 N N    . ALA   A 1 89  ? 21.94130  7.14146   24.50863  1.000 25.33441  ? 451 ALA   A N    1 
ATOM   1204 C CA   . ALA   A 1 89  ? 21.27714  6.29911   23.53248  1.000 28.62024  ? 451 ALA   A CA   1 
ATOM   1205 C C    . ALA   A 1 89  ? 21.50280  6.82886   22.12822  1.000 31.62327  ? 451 ALA   A C    1 
ATOM   1206 O O    . ALA   A 1 89  ? 21.64622  8.03272   21.90944  1.000 32.82751  ? 451 ALA   A O    1 
ATOM   1207 C CB   . ALA   A 1 89  ? 19.78474  6.24939   23.84528  1.000 31.17183  ? 451 ALA   A CB   1 
ATOM   1208 H H    . ALA   A 1 89  ? 21.40846  7.49196   25.08556  1.000 30.41334  ? 451 ALA   A H    1 
ATOM   1209 H HA   . ALA   A 1 89  ? 21.63480  5.39819   23.56888  1.000 34.35634  ? 451 ALA   A HA   1 
ATOM   1210 H HB1  . ALA   A 1 89  ? 19.34494  5.67804   23.19641  1.000 37.41826  ? 451 ALA   A HB1  1 
ATOM   1211 H HB2  . ALA   A 1 89  ? 19.66103  5.89184   24.73845  1.000 37.41826  ? 451 ALA   A HB2  1 
ATOM   1212 H HB3  . ALA   A 1 89  ? 19.42150  7.14741   23.79524  1.000 37.41826  ? 451 ALA   A HB3  1 
ATOM   1213 N N    . LYS   A 1 90  ? 21.54173  5.92646   21.17915  1.000 34.13921  ? 452 LYS   A N    1 
ATOM   1214 C CA   . LYS   A 1 90  ? 21.54990  6.24951   19.75609  1.000 33.63275  ? 452 LYS   A CA   1 
ATOM   1215 C C    . LYS   A 1 90  ? 20.13786  6.14506   19.18075  1.000 36.79731  ? 452 LYS   A C    1 
ATOM   1216 O O    . LYS   A 1 90  ? 19.25813  5.52227   19.78323  1.000 31.46149  ? 452 LYS   A O    1 
ATOM   1217 C CB   . LYS   A 1 90  ? 22.49674  5.29711   19.00669  1.000 41.55107  ? 452 LYS   A CB   1 
ATOM   1218 C CG   . LYS   A 1 90  ? 23.91520  5.27721   19.58563  1.000 46.71342  ? 452 LYS   A CG   1 
ATOM   1219 C CD   . LYS   A 1 90  ? 24.91070  4.47950   18.74877  1.000 56.13448  ? 452 LYS   A CD   1 
ATOM   1220 C CE   . LYS   A 1 90  ? 25.21866  5.15084   17.40751  1.000 62.37937  ? 452 LYS   A CE   1 
ATOM   1221 N NZ   . LYS   A 1 90  ? 26.66178  5.04110   17.05321  1.000 77.57936  ? 452 LYS   A NZ   1 
ATOM   1222 H H    . LYS   A 1 90  ? 21.56518  5.08024   21.33070  1.000 40.97911  ? 452 LYS   A H    1 
ATOM   1223 H HA   . LYS   A 1 90  ? 21.86687  7.15624   19.62091  1.000 40.37135  ? 452 LYS   A HA   1 
ATOM   1224 H HB2  . LYS   A 1 90  ? 22.14083  4.39620   19.05767  1.000 49.87333  ? 452 LYS   A HB2  1 
ATOM   1225 H HB3  . LYS   A 1 90  ? 22.55634  5.57835   18.08028  1.000 49.87333  ? 452 LYS   A HB3  1 
ATOM   1226 H HG2  . LYS   A 1 90  ? 24.24195  6.18869   19.64339  1.000 56.06816  ? 452 LYS   A HG2  1 
ATOM   1227 H HG3  . LYS   A 1 90  ? 23.88643  4.87846   20.46941  1.000 56.06816  ? 452 LYS   A HG3  1 
ATOM   1228 H HD2  . LYS   A 1 90  ? 25.74252  4.39445   19.24044  1.000 67.37343  ? 452 LYS   A HD2  1 
ATOM   1229 H HD3  . LYS   A 1 90  ? 24.54115  3.60116   18.56753  1.000 67.37343  ? 452 LYS   A HD3  1 
ATOM   1230 H HE2  . LYS   A 1 90  ? 24.70064  4.72199   16.70848  1.000 74.86729  ? 452 LYS   A HE2  1 
ATOM   1231 H HE3  . LYS   A 1 90  ? 24.98942  6.09187   17.46045  1.000 74.86729  ? 452 LYS   A HE3  1 
ATOM   1232 H HZ1  . LYS   A 1 90  ? 26.81249  5.42938   16.26668  1.000 93.10729  ? 452 LYS   A HZ1  1 
ATOM   1233 H HZ2  . LYS   A 1 90  ? 27.15876  5.44201   17.67319  1.000 93.10729  ? 452 LYS   A HZ2  1 
ATOM   1234 H HZ3  . LYS   A 1 90  ? 26.89852  4.18466   17.00261  1.000 93.10729  ? 452 LYS   A HZ3  1 
ATOM   1235 N N    . PRO   A 1 91  ? 19.86585  6.76229   18.02347  1.000 34.00212  ? 453 PRO   A N    1 
ATOM   1236 C CA   . PRO   A 1 91  ? 18.52109  6.65433   17.43546  1.000 35.00582  ? 453 PRO   A CA   1 
ATOM   1237 C C    . PRO   A 1 91  ? 18.15894  5.20453   17.16812  1.000 33.35977  ? 453 PRO   A C    1 
ATOM   1238 O O    . PRO   A 1 91  ? 18.98887  4.42573   16.70562  1.000 36.10437  ? 453 PRO   A O    1 
ATOM   1239 C CB   . PRO   A 1 91  ? 18.63505  7.45823   16.13432  1.000 37.28486  ? 453 PRO   A CB   1 
ATOM   1240 C CG   . PRO   A 1 91  ? 19.80573  8.42635   16.38401  1.000 39.32913  ? 453 PRO   A CG   1 
ATOM   1241 C CD   . PRO   A 1 91  ? 20.73961  7.67664   17.25274  1.000 37.92966  ? 453 PRO   A CD   1 
ATOM   1242 H HA   . PRO   A 1 91  ? 17.85533  7.06038   18.01234  1.000 42.01904  ? 453 PRO   A HA   1 
ATOM   1243 H HB2  . PRO   A 1 91  ? 18.82550  6.86392   15.39175  1.000 44.75388  ? 453 PRO   A HB2  1 
ATOM   1244 H HB3  . PRO   A 1 91  ? 17.81076  7.94209   15.96902  1.000 44.75388  ? 453 PRO   A HB3  1 
ATOM   1245 H HG2  . PRO   A 1 91  ? 20.22695  8.66072   15.54226  1.000 47.20701  ? 453 PRO   A HG2  1 
ATOM   1246 H HG3  . PRO   A 1 91  ? 19.48470  9.22653   16.82847  1.000 47.20701  ? 453 PRO   A HG3  1 
ATOM   1247 H HD2  . PRO   A 1 91  ? 21.37388  7.17350   16.71847  1.000 45.52765  ? 453 PRO   A HD2  1 
ATOM   1248 H HD3  . PRO   A 1 91  ? 21.21190  8.28002   17.84753  1.000 45.52765  ? 453 PRO   A HD3  1 
ATOM   1249 N N    . GLY   A 1 92  ? 16.91911  4.82955   17.50867  1.000 32.64344  ? 454 GLY   A N    1 
ATOM   1250 C CA   . GLY   A 1 92  ? 16.46870  3.45256   17.35504  1.000 27.70353  ? 454 GLY   A CA   1 
ATOM   1251 C C    . GLY   A 1 92  ? 16.96827  2.48778   18.40678  1.000 28.96029  ? 454 GLY   A C    1 
ATOM   1252 O O    . GLY   A 1 92  ? 16.61780  1.29820   18.34929  1.000 33.04706  ? 454 GLY   A O    1 
ATOM   1253 H H    . GLY   A 1 92  ? 16.32358  5.35970   17.83101  1.000 39.18418  ? 454 GLY   A H    1 
ATOM   1254 H HA2  . GLY   A 1 92  ? 15.49914  3.44009   17.38158  1.000 33.25629  ? 454 GLY   A HA2  1 
ATOM   1255 H HA3  . GLY   A 1 92  ? 16.76521  3.12527   16.49141  1.000 33.25629  ? 454 GLY   A HA3  1 
ATOM   1256 N N    . ASP   A 1 93  ? 17.80219  2.93299   19.35352  1.000 27.52050  ? 455 ASP   A N    1 
ATOM   1257 C CA   . ASP   A 1 93  ? 18.16608  2.04620   20.45795  1.000 28.24101  ? 455 ASP   A CA   1 
ATOM   1258 C C    . ASP   A 1 93  ? 16.92203  1.66230   21.26186  1.000 24.68314  ? 455 ASP   A C    1 
ATOM   1259 O O    . ASP   A 1 93  ? 16.74996  0.50263   21.64016  1.000 26.77293  ? 455 ASP   A O    1 
ATOM   1260 C CB   . ASP   A 1 93  ? 19.18211  2.70782   21.38288  1.000 32.40302  ? 455 ASP   A CB   1 
ATOM   1261 C CG   . ASP   A 1 93  ? 20.62808  2.50404   20.93456  1.000 33.17753  ? 455 ASP   A CG   1 
ATOM   1262 O OD1  . ASP   A 1 93  ? 20.87223  1.92164   19.85998  1.000 36.86290  ? 455 ASP   A OD1  1 
ATOM   1263 O OD2  . ASP   A 1 93  ? 21.52259  2.88708   21.69805  1.000 37.72310  ? 455 ASP   A OD2  1 
ATOM   1264 H H    . ASP   A 1 93  ? 18.15733  3.71588   19.37730  1.000 33.03666  ? 455 ASP   A H    1 
ATOM   1265 H HA   . ASP   A 1 93  ? 18.57747  1.25012   20.08658  1.000 33.90126  ? 455 ASP   A HA   1 
ATOM   1266 H HB2  . ASP   A 1 93  ? 19.00967  3.66204   21.40775  1.000 38.89568  ? 455 ASP   A HB2  1 
ATOM   1267 H HB3  . ASP   A 1 93  ? 19.08997  2.33076   22.27183  1.000 38.89568  ? 455 ASP   A HB3  1 
ATOM   1268 N N    . PHE   A 1 94  ? 16.03786  2.63109   21.48824  1.000 26.74213  ? 456 PHE   A N    1 
ATOM   1269 C CA   . PHE   A 1 94  ? 14.85897  2.47553   22.34083  1.000 23.02910  ? 456 PHE   A CA   1 
ATOM   1270 C C    . PHE   A 1 94  ? 13.68291  3.10515   21.60979  1.000 24.40333  ? 456 PHE   A C    1 
ATOM   1271 O O    . PHE   A 1 94  ? 13.16785  4.15553   22.00696  1.000 20.88720  ? 456 PHE   A O    1 
ATOM   1272 C CB   . PHE   A 1 94  ? 15.10491  3.14532   23.69861  1.000 28.24568  ? 456 PHE   A CB   1 
ATOM   1273 C CG   . PHE   A 1 94  ? 16.29207  2.58809   24.44714  1.000 27.40233  ? 456 PHE   A CG   1 
ATOM   1274 C CD1  . PHE   A 1 94  ? 16.18304  1.41595   25.20256  1.000 29.36773  ? 456 PHE   A CD1  1 
ATOM   1275 C CD2  . PHE   A 1 94  ? 17.51664  3.22460   24.40031  1.000 24.17442  ? 456 PHE   A CD2  1 
ATOM   1276 C CE1  . PHE   A 1 94  ? 17.26290  0.90511   25.86759  1.000 26.22928  ? 456 PHE   A CE1  1 
ATOM   1277 C CE2  . PHE   A 1 94  ? 18.60990  2.69708   25.05078  1.000 23.49276  ? 456 PHE   A CE2  1 
ATOM   1278 C CZ   . PHE   A 1 94  ? 18.47737  1.55014   25.80780  1.000 29.34798  ? 456 PHE   A CZ   1 
ATOM   1279 H H    . PHE   A 1 94  ? 16.10086  3.41775   21.14647  1.000 32.10261  ? 456 PHE   A H    1 
ATOM   1280 H HA   . PHE   A 1 94  ? 14.66395  1.53796   22.49521  1.000 27.64697  ? 456 PHE   A HA   1 
ATOM   1281 H HB2  . PHE   A 1 94  ? 15.26316  4.09153   23.55527  1.000 33.90687  ? 456 PHE   A HB2  1 
ATOM   1282 H HB3  . PHE   A 1 94  ? 14.31974  3.02072   24.25438  1.000 33.90687  ? 456 PHE   A HB3  1 
ATOM   1283 H HD1  . PHE   A 1 94  ? 15.36428  0.97780   25.25320  1.000 35.25332  ? 456 PHE   A HD1  1 
ATOM   1284 H HD2  . PHE   A 1 94  ? 17.60408  4.01860   23.92406  1.000 29.02136  ? 456 PHE   A HD2  1 
ATOM   1285 H HE1  . PHE   A 1 94  ? 17.17681  0.12130   26.36068  1.000 31.48719  ? 456 PHE   A HE1  1 
ATOM   1286 H HE2  . PHE   A 1 94  ? 19.43827  3.11385   24.98003  1.000 28.20337  ? 456 PHE   A HE2  1 
ATOM   1287 H HZ   . PHE   A 1 94  ? 19.20707  1.21410   26.27631  1.000 35.22963  ? 456 PHE   A HZ   1 
ATOM   1288 N N    . PRO   A 1 95  ? 13.23978  2.48748   20.50287  1.000 23.70979  ? 457 PRO   A N    1 
ATOM   1289 C CA   . PRO   A 1 95  ? 12.17952  3.10750   19.70548  1.000 23.88847  ? 457 PRO   A CA   1 
ATOM   1290 C C    . PRO   A 1 95  ? 10.86783  3.12218   20.42201  1.000 23.79344  ? 457 PRO   A C    1 
ATOM   1291 O O    . PRO   A 1 95  ? 9.95920   3.80932   19.98374  1.000 23.25726  ? 457 PRO   A O    1 
ATOM   1292 C CB   . PRO   A 1 95  ? 12.11689  2.24395   18.44175  1.000 27.96578  ? 457 PRO   A CB   1 
ATOM   1293 C CG   . PRO   A 1 95  ? 12.77504  0.94169   18.79950  1.000 26.97531  ? 457 PRO   A CG   1 
ATOM   1294 C CD   . PRO   A 1 95  ? 13.68307  1.19589   19.95757  1.000 25.68330  ? 457 PRO   A CD   1 
ATOM   1295 H HA   . PRO   A 1 95  ? 12.42895  4.00830   19.44617  1.000 28.67822  ? 457 PRO   A HA   1 
ATOM   1296 H HB2  . PRO   A 1 95  ? 11.19126  2.10309   18.18823  1.000 33.57099  ? 457 PRO   A HB2  1 
ATOM   1297 H HB3  . PRO   A 1 95  ? 12.59480  2.68422   17.72157  1.000 33.57099  ? 457 PRO   A HB3  1 
ATOM   1298 H HG2  . PRO   A 1 95  ? 12.09373  0.29496   19.04129  1.000 32.38243  ? 457 PRO   A HG2  1 
ATOM   1299 H HG3  . PRO   A 1 95  ? 13.28240  0.62005   18.03790  1.000 32.38243  ? 457 PRO   A HG3  1 
ATOM   1300 H HD2  . PRO   A 1 95  ? 13.58959  0.49609   20.62273  1.000 30.83202  ? 457 PRO   A HD2  1 
ATOM   1301 H HD3  . PRO   A 1 95  ? 14.60498  1.25065   19.66094  1.000 30.83202  ? 457 PRO   A HD3  1 
ATOM   1302 N N    . TRP   A 1 96  ? 10.71539  2.33541   21.47493  1.000 22.59520  ? 458 TRP   A N    1 
ATOM   1303 C CA   . TRP   A 1 96  ? 9.51495   2.37161   22.29101  1.000 21.52416  ? 458 TRP   A CA   1 
ATOM   1304 C C    . TRP   A 1 96  ? 9.51770   3.48580   23.32324  1.000 25.32848  ? 458 TRP   A C    1 
ATOM   1305 O O    . TRP   A 1 96  ? 8.49327   3.65838   24.00249  1.000 26.18052  ? 458 TRP   A O    1 
ATOM   1306 C CB   . TRP   A 1 96  ? 9.34035   1.05443   23.05790  1.000 22.71329  ? 458 TRP   A CB   1 
ATOM   1307 C CG   . TRP   A 1 96  ? 10.57605  0.64301   23.74328  1.000 25.13640  ? 458 TRP   A CG   1 
ATOM   1308 C CD1  . TRP   A 1 96  ? 11.05308  1.07532   24.94144  1.000 23.87883  ? 458 TRP   A CD1  1 
ATOM   1309 C CD2  . TRP   A 1 96  ? 11.56074  -0.24934  23.20979  1.000 24.46474  ? 458 TRP   A CD2  1 
ATOM   1310 N NE1  . TRP   A 1 96  ? 12.25980  0.49219   25.19247  1.000 23.22682  ? 458 TRP   A NE1  1 
ATOM   1311 C CE2  . TRP   A 1 96  ? 12.60119  -0.31522  24.13877  1.000 20.94322  ? 458 TRP   A CE2  1 
ATOM   1312 C CE3  . TRP   A 1 96  ? 11.66031  -0.98672  22.02351  1.000 24.25998  ? 458 TRP   A CE3  1 
ATOM   1313 C CZ2  . TRP   A 1 96  ? 13.70517  -1.11281  23.94595  1.000 24.99444  ? 458 TRP   A CZ2  1 
ATOM   1314 C CZ3  . TRP   A 1 96  ? 12.77891  -1.77412  21.83125  1.000 25.17842  ? 458 TRP   A CZ3  1 
ATOM   1315 C CH2  . TRP   A 1 96  ? 13.77901  -1.82023  22.76719  1.000 25.93502  ? 458 TRP   A CH2  1 
ATOM   1316 H H    . TRP   A 1 96  ? 11.30056  1.76418   21.74115  1.000 27.12629  ? 458 TRP   A H    1 
ATOM   1317 H HA   . TRP   A 1 96  ? 8.76731   2.49552   21.68554  1.000 25.84104  ? 458 TRP   A HA   1 
ATOM   1318 H HB2  . TRP   A 1 96  ? 8.64598   1.16505   23.72612  1.000 27.26801  ? 458 TRP   A HB2  1 
ATOM   1319 H HB3  . TRP   A 1 96  ? 9.09229   0.35389   22.43452  1.000 27.26801  ? 458 TRP   A HB3  1 
ATOM   1320 H HD1  . TRP   A 1 96  ? 10.62171  1.67724   25.50404  1.000 28.66665  ? 458 TRP   A HD1  1 
ATOM   1321 H HE1  . TRP   A 1 96  ? 12.73254  0.61217   25.90080  1.000 27.88424  ? 458 TRP   A HE1  1 
ATOM   1322 H HE3  . TRP   A 1 96  ? 10.98950  -0.94729  21.38058  1.000 29.12403  ? 458 TRP   A HE3  1 
ATOM   1323 H HZ2  . TRP   A 1 96  ? 14.37603  -1.17193  24.58732  1.000 30.00538  ? 458 TRP   A HZ2  1 
ATOM   1324 H HZ3  . TRP   A 1 96  ? 12.85449  -2.28061  21.05494  1.000 30.22616  ? 458 TRP   A HZ3  1 
ATOM   1325 H HH2  . TRP   A 1 96  ? 14.52906  -2.34444  22.60126  1.000 31.13408  ? 458 TRP   A HH2  1 
ATOM   1326 N N    . GLN   A 1 97  ? 10.63025  4.21160   23.49724  1.000 24.34684  ? 459 GLN   A N    1 
ATOM   1327 C CA   . GLN   A 1 97  ? 10.69866  5.18104   24.58863  1.000 24.90023  ? 459 GLN   A CA   1 
ATOM   1328 C C    . GLN   A 1 97  ? 9.66335   6.28192   24.37909  1.000 22.01174  ? 459 GLN   A C    1 
ATOM   1329 O O    . GLN   A 1 97  ? 9.61192   6.90957   23.32637  1.000 24.81054  ? 459 GLN   A O    1 
ATOM   1330 C CB   . GLN   A 1 97  ? 12.09028  5.79378   24.69155  1.000 27.99018  ? 459 GLN   A CB   1 
ATOM   1331 C CG   . GLN   A 1 97  ? 12.25641  6.75175   25.85420  1.000 21.92964  ? 459 GLN   A CG   1 
ATOM   1332 C CD   . GLN   A 1 97  ? 12.36591  6.08139   27.21479  1.000 27.44162  ? 459 GLN   A CD   1 
ATOM   1333 O OE1  . GLN   A 1 97  ? 12.72995  4.91725   27.32742  1.000 27.95428  ? 459 GLN   A OE1  1 
ATOM   1334 N NE2  . GLN   A 1 97  ? 12.09244  6.84260   28.26267  1.000 25.68993  ? 459 GLN   A NE2  1 
ATOM   1335 H H    . GLN   A 1 97  ? 11.33669  4.16050   23.00946  1.000 29.22826  ? 459 GLN   A H    1 
ATOM   1336 H HA   . GLN   A 1 97  ? 10.51358  4.72301   25.42341  1.000 29.89233  ? 459 GLN   A HA   1 
ATOM   1337 H HB2  . GLN   A 1 97  ? 12.73716  5.07956   24.80266  1.000 33.60027  ? 459 GLN   A HB2  1 
ATOM   1338 H HB3  . GLN   A 1 97  ? 12.27505  6.28478   23.87565  1.000 33.60027  ? 459 GLN   A HB3  1 
ATOM   1339 H HG2  . GLN   A 1 97  ? 13.06630  7.26752   25.71650  1.000 26.32762  ? 459 GLN   A HG2  1 
ATOM   1340 H HG3  . GLN   A 1 97  ? 11.48739  7.34236   25.88044  1.000 26.32762  ? 459 GLN   A HG3  1 
ATOM   1341 H HE21 . GLN   A 1 97  ? 11.86853  7.66524   28.14985  1.000 30.83997  ? 459 GLN   A HE21 1 
ATOM   1342 H HE22 . GLN   A 1 97  ? 12.13869  6.51451   29.05628  1.000 30.83997  ? 459 GLN   A HE22 1 
ATOM   1343 N N    . VAL   A 1 98  ? 8.90260   6.56378   25.42414  1.000 23.87642  ? 460 VAL   A N    1 
ATOM   1344 C CA   . VAL   A 1 98  ? 7.89382   7.62188   25.39092  1.000 26.82404  ? 460 VAL   A CA   1 
ATOM   1345 C C    . VAL   A 1 98  ? 8.20175   8.60834   26.50101  1.000 26.50691  ? 460 VAL   A C    1 
ATOM   1346 O O    . VAL   A 1 98  ? 8.48898   8.20861   27.63350  1.000 25.80365  ? 460 VAL   A O    1 
ATOM   1347 C CB   . VAL   A 1 98  ? 6.48124   7.00939   25.54586  1.000 27.04836  ? 460 VAL   A CB   1 
ATOM   1348 C CG1  . VAL   A 1 98  ? 5.48437   7.98522   26.03724  1.000 34.05900  ? 460 VAL   A CG1  1 
ATOM   1349 C CG2  . VAL   A 1 98  ? 6.06004   6.44713   24.23255  1.000 28.06668  ? 460 VAL   A CG2  1 
ATOM   1350 H H    . VAL   A 1 98  ? 8.94959   6.15185   26.17761  1.000 28.66376  ? 460 VAL   A H    1 
ATOM   1351 H HA   . VAL   A 1 98  ? 7.93076   8.10884   24.55283  1.000 32.20091  ? 460 VAL   A HA   1 
ATOM   1352 H HB   . VAL   A 1 98  ? 6.52008   6.30855   26.21534  1.000 32.47008  ? 460 VAL   A HB   1 
ATOM   1353 H HG11 . VAL   A 1 98  ? 4.59441   7.65619   25.83573  1.000 40.88286  ? 460 VAL   A HG11 1 
ATOM   1354 H HG12 . VAL   A 1 98  ? 5.58960   8.08859   26.99596  1.000 40.88286  ? 460 VAL   A HG12 1 
ATOM   1355 H HG13 . VAL   A 1 98  ? 5.63054   8.83598   25.59480  1.000 40.88286  ? 460 VAL   A HG13 1 
ATOM   1356 H HG21 . VAL   A 1 98  ? 5.22357   5.96953   24.34715  1.000 33.69207  ? 460 VAL   A HG21 1 
ATOM   1357 H HG22 . VAL   A 1 98  ? 5.94213   7.17392   23.60106  1.000 33.69207  ? 460 VAL   A HG22 1 
ATOM   1358 H HG23 . VAL   A 1 98  ? 6.74648   5.84029   23.91405  1.000 33.69207  ? 460 VAL   A HG23 1 
ATOM   1359 N N    . LEU   A 1 99  ? 8.12258   9.90674   26.17060  1.000 22.59255  ? 461 LEU   A N    1 
ATOM   1360 C CA   . LEU   A 1 99  ? 8.19439   10.99996  27.13074  1.000 24.77045  ? 461 LEU   A CA   1 
ATOM   1361 C C    . LEU   A 1 99  ? 6.78566   11.44632  27.46782  1.000 24.60728  ? 461 LEU   A C    1 
ATOM   1362 O O    . LEU   A 1 99  ? 5.96407   11.67305  26.56180  1.000 28.74890  ? 461 LEU   A O    1 
ATOM   1363 C CB   . LEU   A 1 99  ? 8.99804   12.17202  26.56529  1.000 24.01362  ? 461 LEU   A CB   1 
ATOM   1364 C CG   . LEU   A 1 99  ? 9.14194   13.46111  27.39004  1.000 24.37052  ? 461 LEU   A CG   1 
ATOM   1365 C CD1  . LEU   A 1 99  ? 9.99269   13.21932  28.61348  1.000 32.19578  ? 461 LEU   A CD1  1 
ATOM   1366 C CD2  . LEU   A 1 99  ? 9.75863   14.57965  26.51345  1.000 27.91110  ? 461 LEU   A CD2  1 
ATOM   1367 H H    . LEU   A 1 99  ? 8.02319   10.18225  25.36201  1.000 27.12311  ? 461 LEU   A H    1 
ATOM   1368 H HA   . LEU   A 1 99  ? 8.63306   10.69907  27.94187  1.000 29.73659  ? 461 LEU   A HA   1 
ATOM   1369 H HB2  . LEU   A 1 99  ? 9.89904   11.85179  26.40236  1.000 28.82839  ? 461 LEU   A HB2  1 
ATOM   1370 H HB3  . LEU   A 1 99  ? 8.58126   12.43015  25.72829  1.000 28.82839  ? 461 LEU   A HB3  1 
ATOM   1371 H HG   . LEU   A 1 99  ? 8.26589   13.74938  27.69059  1.000 29.25668  ? 461 LEU   A HG   1 
ATOM   1372 H HD11 . LEU   A 1 99  ? 10.06393  14.04541  29.11687  1.000 38.64700  ? 461 LEU   A HD11 1 
ATOM   1373 H HD12 . LEU   A 1 99  ? 9.57441   12.53474  29.15872  1.000 38.64700  ? 461 LEU   A HD12 1 
ATOM   1374 H HD13 . LEU   A 1 99  ? 10.87362  12.92609  28.33263  1.000 38.64700  ? 461 LEU   A HD13 1 
ATOM   1375 H HD21 . LEU   A 1 99  ? 9.88113   15.37450  27.05577  1.000 33.50538  ? 461 LEU   A HD21 1 
ATOM   1376 H HD22 . LEU   A 1 99  ? 10.61458  14.27726  26.17167  1.000 33.50538  ? 461 LEU   A HD22 1 
ATOM   1377 H HD23 . LEU   A 1 99  ? 9.15733   14.77126  25.77681  1.000 33.50538  ? 461 LEU   A HD23 1 
ATOM   1378 N N    . ILE   A 1 100 ? 6.50112   11.58721  28.76045  1.000 30.56398  ? 462 ILE   A N    1 
ATOM   1379 C CA   . ILE   A 1 100 ? 5.20739   12.03270  29.26079  1.000 25.92638  ? 462 ILE   A CA   1 
ATOM   1380 C C    . ILE   A 1 100 ? 5.41024   13.34476  29.99916  1.000 34.05352  ? 462 ILE   A C    1 
ATOM   1381 O O    . ILE   A 1 100 ? 6.00035   13.34723  31.08763  1.000 32.95530  ? 462 ILE   A O    1 
ATOM   1382 C CB   . ILE   A 1 100 ? 4.55155   11.01026  30.19381  1.000 23.97913  ? 462 ILE   A CB   1 
ATOM   1383 C CG1  . ILE   A 1 100 ? 4.35307   9.64796   29.49014  1.000 27.36373  ? 462 ILE   A CG1  1 
ATOM   1384 C CG2  . ILE   A 1 100 ? 3.19401   11.55125  30.68305  1.000 26.94258  ? 462 ILE   A CG2  1 
ATOM   1385 C CD1  . ILE   A 1 100 ? 3.95018   8.52919   30.43003  1.000 30.13650  ? 462 ILE   A CD1  1 
ATOM   1386 H H    . ILE   A 1 100 ? 7.06485   11.42381  29.38903  1.000 36.68883  ? 462 ILE   A H    1 
ATOM   1387 H HA   . ILE   A 1 100 ? 4.62836   12.18503  28.49763  1.000 31.12371  ? 462 ILE   A HA   1 
ATOM   1388 H HB   . ILE   A 1 100 ? 5.14337   10.87198  30.94981  1.000 28.78701  ? 462 ILE   A HB   1 
ATOM   1389 H HG12 . ILE   A 1 100 ? 3.65502   9.74016   28.82297  1.000 32.84853  ? 462 ILE   A HG12 1 
ATOM   1390 H HG13 . ILE   A 1 100 ? 5.18655   9.39198   29.06505  1.000 32.84853  ? 462 ILE   A HG13 1 
ATOM   1391 H HG21 . ILE   A 1 100 ? 2.69767   10.82912  31.09908  1.000 32.34315  ? 462 ILE   A HG21 1 
ATOM   1392 H HG22 . ILE   A 1 100 ? 3.34991   12.25952  31.32721  1.000 32.34315  ? 462 ILE   A HG22 1 
ATOM   1393 H HG23 . ILE   A 1 100 ? 2.69989   11.89768  29.92362  1.000 32.34315  ? 462 ILE   A HG23 1 
ATOM   1394 H HD11 . ILE   A 1 100 ? 4.09910   7.67781   29.98972  1.000 36.17585  ? 462 ILE   A HD11 1 
ATOM   1395 H HD12 . ILE   A 1 100 ? 4.48847   8.58385   31.23511  1.000 36.17585  ? 462 ILE   A HD12 1 
ATOM   1396 H HD13 . ILE   A 1 100 ? 3.01113   8.62662   30.65273  1.000 36.17585  ? 462 ILE   A HD13 1 
ATOM   1397 N N    . LEU   A 1 101 ? 4.87461   14.44139  29.45062  1.000 34.10644  ? 463 LEU   A N    1 
ATOM   1398 C CA   . LEU   A 1 101 ? 5.01099   15.76915  30.04553  1.000 42.41465  ? 463 LEU   A CA   1 
ATOM   1399 C C    . LEU   A 1 101 ? 3.67335   16.30176  30.54807  1.000 53.70779  ? 463 LEU   A C    1 
ATOM   1400 O O    . LEU   A 1 101 ? 2.59282   15.88774  30.11322  1.000 54.91570  ? 463 LEU   A O    1 
ATOM   1401 C CB   . LEU   A 1 101 ? 5.59185   16.78992  29.05656  1.000 39.48366  ? 463 LEU   A CB   1 
ATOM   1402 C CG   . LEU   A 1 101 ? 7.00524   16.48988  28.56718  1.000 49.52591  ? 463 LEU   A CG   1 
ATOM   1403 C CD1  . LEU   A 1 101 ? 7.28732   17.28721  27.32627  1.000 46.16226  ? 463 LEU   A CD1  1 
ATOM   1404 C CD2  . LEU   A 1 101 ? 8.07723   16.74894  29.63087  1.000 46.01478  ? 463 LEU   A CD2  1 
ATOM   1405 H H    . LEU   A 1 101 ? 4.42016   14.43753  28.72051  1.000 40.93978  ? 463 LEU   A H    1 
ATOM   1406 H HA   . LEU   A 1 101 ? 5.61490   15.67905  30.79923  1.000 50.90963  ? 463 LEU   A HA   1 
ATOM   1407 H HB2  . LEU   A 1 101 ? 5.01533   16.82219  28.27715  1.000 47.39244  ? 463 LEU   A HB2  1 
ATOM   1408 H HB3  . LEU   A 1 101 ? 5.61258   17.65743  29.49003  1.000 47.39244  ? 463 LEU   A HB3  1 
ATOM   1409 H HG   . LEU   A 1 101 ? 7.05633   15.54259  28.36486  1.000 59.44315  ? 463 LEU   A HG   1 
ATOM   1410 H HD11 . LEU   A 1 101 ? 8.18847   17.09320  27.02428  1.000 55.40677  ? 463 LEU   A HD11 1 
ATOM   1411 H HD12 . LEU   A 1 101 ? 6.64804   17.03996  26.63991  1.000 55.40677  ? 463 LEU   A HD12 1 
ATOM   1412 H HD13 . LEU   A 1 101 ? 7.20342   18.23147  27.53174  1.000 55.40677  ? 463 LEU   A HD13 1 
ATOM   1413 H HD21 . LEU   A 1 101 ? 8.94558   16.51435  29.26778  1.000 55.22979  ? 463 LEU   A HD21 1 
ATOM   1414 H HD22 . LEU   A 1 101 ? 8.06234   17.68838  29.87197  1.000 55.22979  ? 463 LEU   A HD22 1 
ATOM   1415 H HD23 . LEU   A 1 101 ? 7.88659   16.20428  30.41055  1.000 55.22979  ? 463 LEU   A HD23 1 
ATOM   1416 N N    . GLY   A 1 102 ? 3.77409   17.25735  31.45966  1.000 67.03985  ? 464 GLY   A N    1 
ATOM   1417 C CA   . GLY   A 1 102 ? 2.61863   17.87478  32.06579  1.000 75.50717  ? 464 GLY   A CA   1 
ATOM   1418 C C    . GLY   A 1 102 ? 2.96546   18.18227  33.50074  1.000 78.15128  ? 464 GLY   A C    1 
ATOM   1419 O O    . GLY   A 1 102 ? 3.72707   19.11526  33.78352  1.000 74.52346  ? 464 GLY   A O    1 
ATOM   1420 H H    . GLY   A 1 102 ? 4.52130   17.57039  31.74825  1.000 80.45988  ? 464 GLY   A H    1 
ATOM   1421 H HA2  . GLY   A 1 102 ? 2.39056   18.69590  31.60248  1.000 90.62066  ? 464 GLY   A HA2  1 
ATOM   1422 H HA3  . GLY   A 1 102 ? 1.85796   17.27362  32.03598  1.000 90.62066  ? 464 GLY   A HA3  1 
ATOM   1423 N N    . GLY   A 1 103 ? 2.42591   17.38458  34.41169  1.000 80.99506  ? 465 GLY   A N    1 
ATOM   1424 C CA   . GLY   A 1 103 ? 2.93772   17.35418  35.75983  1.000 91.21224  ? 465 GLY   A CA   1 
ATOM   1425 C C    . GLY   A 1 103 ? 4.21168   16.54499  35.75108  1.000 80.89834  ? 465 GLY   A C    1 
ATOM   1426 O O    . GLY   A 1 103 ? 4.16685   15.32987  35.54704  1.000 78.02315  ? 465 GLY   A O    1 
ATOM   1427 H H    . GLY   A 1 103 ? 1.76398   16.85456  34.26841  1.000 97.20613  ? 465 GLY   A H    1 
ATOM   1428 H HA2  . GLY   A 1 103 ? 3.12577   18.25346  36.07098  1.000 109.46674 ? 465 GLY   A HA2  1 
ATOM   1429 H HA3  . GLY   A 1 103 ? 2.29437   16.94144  36.35703  1.000 109.46674 ? 465 GLY   A HA3  1 
ATOM   1430 N N    . THR   A 1 104 ? 5.34457   17.24556  35.86696  1.000 76.15905  ? 466 THR   A N    1 
ATOM   1431 C CA   . THR   A 1 104 ? 6.69384   16.69475  36.00520  1.000 63.45656  ? 466 THR   A CA   1 
ATOM   1432 C C    . THR   A 1 104 ? 7.08538   15.82946  34.80690  1.000 59.84442  ? 466 THR   A C    1 
ATOM   1433 O O    . THR   A 1 104 ? 6.24900   15.48764  33.96004  1.000 61.96672  ? 466 THR   A O    1 
ATOM   1434 C CB   . THR   A 1 104 ? 6.83222   15.95487  37.35790  1.000 75.03426  ? 466 THR   A CB   1 
ATOM   1435 O OG1  . THR   A 1 104 ? 8.20944   15.98413  37.76316  1.000 71.93868  ? 466 THR   A OG1  1 
ATOM   1436 C CG2  . THR   A 1 104 ? 6.36750   14.46725  37.35386  1.000 85.83668  ? 466 THR   A CG2  1 
ATOM   1437 H H    . THR   A 1 104 ? 5.35862   18.10544  35.86827  1.000 91.40291  ? 466 THR   A H    1 
ATOM   1438 H HA   . THR   A 1 104 ? 7.33796   17.41995  36.01477  1.000 76.15993  ? 466 THR   A HA   1 
ATOM   1439 H HB   . THR   A 1 104 ? 6.24704   16.41414  37.98042  1.000 90.05316  ? 466 THR   A HB   1 
ATOM   1440 H HG1  . THR   A 1 104 ? 8.30150   15.58592  38.49702  1.000 86.33847  ? 466 THR   A HG1  1 
ATOM   1441 H HG21 . THR   A 1 104 ? 6.48714   14.07990  38.23508  1.000 103.01607 ? 466 THR   A HG21 1 
ATOM   1442 H HG22 . THR   A 1 104 ? 5.42998   14.41321  37.11089  1.000 103.01607 ? 466 THR   A HG22 1 
ATOM   1443 H HG23 . THR   A 1 104 ? 6.88860   13.95863  36.71303  1.000 103.01607 ? 466 THR   A HG23 1 
ATOM   1444 N N    . THR   A 1 105 ? 8.37120   15.51517  34.69531  1.000 47.37271  ? 467 THR   A N    1 
ATOM   1445 C CA   . THR   A 1 105 ? 8.87621   14.70088  33.60233  1.000 41.48540  ? 467 THR   A CA   1 
ATOM   1446 C C    . THR   A 1 105 ? 8.79857   13.21450  33.95720  1.000 34.34660  ? 467 THR   A C    1 
ATOM   1447 O O    . THR   A 1 105 ? 9.16909   12.79468  35.05515  1.000 30.48195  ? 467 THR   A O    1 
ATOM   1448 C CB   . THR   A 1 105 ? 10.31121  15.10083  33.27093  1.000 40.93420  ? 467 THR   A CB   1 
ATOM   1449 O OG1  . THR   A 1 105 ? 10.39200  16.52979  33.25013  1.000 52.30708  ? 467 THR   A OG1  1 
ATOM   1450 C CG2  . THR   A 1 105 ? 10.76774  14.52772  31.92841  1.000 39.47761  ? 467 THR   A CG2  1 
ATOM   1451 H H    . THR   A 1 105 ? 8.97855   15.76658  35.24986  1.000 56.85931  ? 467 THR   A H    1 
ATOM   1452 H HA   . THR   A 1 105 ? 8.32539   14.84001  32.81612  1.000 49.79453  ? 467 THR   A HA   1 
ATOM   1453 H HB   . THR   A 1 105 ? 10.91182  14.74206  33.94282  1.000 49.13309  ? 467 THR   A HB   1 
ATOM   1454 H HG1  . THR   A 1 105 ? 11.11268  16.77162  32.89274  1.000 62.78055  ? 467 THR   A HG1  1 
ATOM   1455 H HG21 . THR   A 1 105 ? 11.73233  14.42558  31.92208  1.000 47.38519  ? 467 THR   A HG21 1 
ATOM   1456 H HG22 . THR   A 1 105 ? 10.35840  13.66070  31.78138  1.000 47.38519  ? 467 THR   A HG22 1 
ATOM   1457 H HG23 . THR   A 1 105 ? 10.50958  15.12394  31.20815  1.000 47.38519  ? 467 THR   A HG23 1 
ATOM   1458 N N    . ALA   A 1 106 ? 8.29646   12.42582  33.02801  1.000 30.29736  ? 468 ALA   A N    1 
ATOM   1459 C CA   . ALA   A 1 106 ? 8.25124   10.99409  33.23835  1.000 27.96562  ? 468 ALA   A CA   1 
ATOM   1460 C C    . ALA   A 1 106 ? 8.34773   10.32797  31.88447  1.000 29.05704  ? 468 ALA   A C    1 
ATOM   1461 O O    . ALA   A 1 106 ? 8.57572   10.99016  30.86656  1.000 27.74526  ? 468 ALA   A O    1 
ATOM   1462 C CB   . ALA   A 1 106 ? 6.98182   10.62827  34.01041  1.000 25.39950  ? 468 ALA   A CB   1 
ATOM   1463 H H    . ALA   A 1 106 ? 7.97891   12.69312  32.27481  1.000 36.36889  ? 468 ALA   A H    1 
ATOM   1464 H HA   . ALA   A 1 106 ? 9.01482   10.70621  33.76272  1.000 33.57079  ? 468 ALA   A HA   1 
ATOM   1465 H HB1  . ALA   A 1 106 ? 7.10410   9.76045   34.42615  1.000 30.49145  ? 468 ALA   A HB1  1 
ATOM   1466 H HB2  . ALA   A 1 106 ? 6.82083   11.30106  34.69036  1.000 30.49145  ? 468 ALA   A HB2  1 
ATOM   1467 H HB3  . ALA   A 1 106 ? 6.23456   10.59680  33.39274  1.000 30.49145  ? 468 ALA   A HB3  1 
ATOM   1468 N N    . ALA   A 1 107 ? 8.13134   9.01808   31.86726  1.000 28.32306  ? 469 ALA   A N    1 
ATOM   1469 C CA   . ALA   A 1 107 ? 8.32810   8.26256   30.64890  1.000 23.41559  ? 469 ALA   A CA   1 
ATOM   1470 C C    . ALA   A 1 107 ? 7.36839   7.08546   30.64108  1.000 25.84022  ? 469 ALA   A C    1 
ATOM   1471 O O    . ALA   A 1 107 ? 6.69143   6.79125   31.62811  1.000 26.53440  ? 469 ALA   A O    1 
ATOM   1472 C CB   . ALA   A 1 107 ? 9.78732   7.82696   30.55546  1.000 26.02710  ? 469 ALA   A CB   1 
ATOM   1473 H H    . ALA   A 1 107 ? 7.87307   8.55364   32.54343  1.000 33.99972  ? 469 ALA   A H    1 
ATOM   1474 H HA   . ALA   A 1 107 ? 8.11341   8.79615   29.86782  1.000 28.11076  ? 469 ALA   A HA   1 
ATOM   1475 H HB1  . ALA   A 1 107 ? 9.90990   7.30485   29.74721  1.000 31.24457  ? 469 ALA   A HB1  1 
ATOM   1476 H HB2  . ALA   A 1 107 ? 10.35124  8.61574   30.52843  1.000 31.24457  ? 469 ALA   A HB2  1 
ATOM   1477 H HB3  . ALA   A 1 107 ? 10.00693  7.28981   31.33273  1.000 31.24457  ? 469 ALA   A HB3  1 
ATOM   1478 N N    . GLY   A 1 108 ? 7.33937   6.40188   29.51479  1.000 22.76268  ? 470 GLY   A N    1 
ATOM   1479 C CA   . GLY   A 1 108 ? 6.54441   5.20606   29.36559  1.000 24.20748  ? 470 GLY   A CA   1 
ATOM   1480 C C    . GLY   A 1 108 ? 7.20191   4.41715   28.27472  1.000 22.11211  ? 470 GLY   A C    1 
ATOM   1481 O O    . GLY   A 1 108 ? 8.24805   4.79706   27.77772  1.000 21.38864  ? 470 GLY   A O    1 
ATOM   1482 H H    . GLY   A 1 108 ? 7.78065   6.61488   28.80804  1.000 27.32727  ? 470 GLY   A H    1 
ATOM   1483 H HA2  . GLY   A 1 108 ? 6.53263   4.69216   30.18819  1.000 29.06103  ? 470 GLY   A HA2  1 
ATOM   1484 H HA3  . GLY   A 1 108 ? 5.63269   5.42415   29.11639  1.000 29.06103  ? 470 GLY   A HA3  1 
ATOM   1485 N N    . ALA   A 1 109 ? 6.54459   3.32799   27.87006  1.000 24.12442  ? 471 ALA   A N    1 
ATOM   1486 C CA   . ALA   A 1 109 ? 6.95916   2.50696   26.74336  1.000 23.70125  ? 471 ALA   A CA   1 
ATOM   1487 C C    . ALA   A 1 109 ? 5.75692   2.27189   25.82123  1.000 23.49226  ? 471 ALA   A C    1 
ATOM   1488 O O    . ALA   A 1 109 ? 4.65509   1.93008   26.28447  1.000 20.96820  ? 471 ALA   A O    1 
ATOM   1489 C CB   . ALA   A 1 109 ? 7.48903   1.18037   27.24736  1.000 24.66158  ? 471 ALA   A CB   1 
ATOM   1490 H H    . ALA   A 1 109 ? 5.82958   3.03813   28.24998  1.000 28.96135  ? 471 ALA   A H    1 
ATOM   1491 H HA   . ALA   A 1 109 ? 7.64711   2.95949   26.23068  1.000 28.45356  ? 471 ALA   A HA   1 
ATOM   1492 H HB1  . ALA   A 1 109 ? 7.71661   0.62200   26.48754  1.000 29.60594  ? 471 ALA   A HB1  1 
ATOM   1493 H HB2  . ALA   A 1 109 ? 8.27810   1.34047   27.78833  1.000 29.60594  ? 471 ALA   A HB2  1 
ATOM   1494 H HB3  . ALA   A 1 109 ? 6.80379   0.74897   27.78143  1.000 29.60594  ? 471 ALA   A HB3  1 
ATOM   1495 N N    . LEU   A 1 110 ? 5.95797   2.46023   24.52861  1.000 21.43049  ? 472 LEU   A N    1 
ATOM   1496 C CA   . LEU   A 1 110 ? 4.88141   2.17485   23.58927  1.000 21.69074  ? 472 LEU   A CA   1 
ATOM   1497 C C    . LEU   A 1 110 ? 4.55886   0.67468   23.53659  1.000 24.17732  ? 472 LEU   A C    1 
ATOM   1498 O O    . LEU   A 1 110 ? 5.44867   -0.18546  23.45253  1.000 22.59319  ? 472 LEU   A O    1 
ATOM   1499 C CB   . LEU   A 1 110 ? 5.25589   2.67568   22.18501  1.000 22.25656  ? 472 LEU   A CB   1 
ATOM   1500 C CG   . LEU   A 1 110 ? 4.17570   2.47246   21.09260  1.000 21.67762  ? 472 LEU   A CG   1 
ATOM   1501 C CD1  . LEU   A 1 110 ? 3.01251   3.35182   21.32064  1.000 28.02963  ? 472 LEU   A CD1  1 
ATOM   1502 C CD2  . LEU   A 1 110 ? 4.78312   2.73723   19.70924  1.000 27.24721  ? 472 LEU   A CD2  1 
ATOM   1503 H H    . LEU   A 1 110 ? 6.68855   2.74502   24.17540  1.000 25.72864  ? 472 LEU   A H    1 
ATOM   1504 H HA   . LEU   A 1 110 ? 4.08199   2.63795   23.88483  1.000 26.04094  ? 472 LEU   A HA   1 
ATOM   1505 H HB2  . LEU   A 1 110 ? 5.43643   3.62717   22.23958  1.000 26.71992  ? 472 LEU   A HB2  1 
ATOM   1506 H HB3  . LEU   A 1 110 ? 6.05202   2.20299   21.89581  1.000 26.71992  ? 472 LEU   A HB3  1 
ATOM   1507 H HG   . LEU   A 1 110 ? 3.85846   1.55651   21.12846  1.000 26.02520  ? 472 LEU   A HG   1 
ATOM   1508 H HD11 . LEU   A 1 110 ? 2.32512   3.14149   20.66936  1.000 33.64761  ? 472 LEU   A HD11 1 
ATOM   1509 H HD12 . LEU   A 1 110 ? 2.67496   3.20272   22.21770  1.000 33.64761  ? 472 LEU   A HD12 1 
ATOM   1510 H HD13 . LEU   A 1 110 ? 3.29077   4.27571   21.22123  1.000 33.64761  ? 472 LEU   A HD13 1 
ATOM   1511 H HD21 . LEU   A 1 110 ? 4.09382   2.62817   19.03554  1.000 32.70870  ? 472 LEU   A HD21 1 
ATOM   1512 H HD22 . LEU   A 1 110 ? 5.12946   3.64296   19.68451  1.000 32.70870  ? 472 LEU   A HD22 1 
ATOM   1513 H HD23 . LEU   A 1 110 ? 5.50125   2.10411   19.55323  1.000 32.70870  ? 472 LEU   A HD23 1 
ATOM   1514 N N    . LEU   A 1 111 ? 3.25019   0.37126   23.53754  1.000 22.38179  ? 473 LEU   A N    1 
ATOM   1515 C CA   . LEU   A 1 111 ? 2.75514   -0.97502  23.28170  1.000 28.37141  ? 473 LEU   A CA   1 
ATOM   1516 C C    . LEU   A 1 111 ? 1.81238   -0.92945  22.08107  1.000 26.98971  ? 473 LEU   A C    1 
ATOM   1517 O O    . LEU   A 1 111 ? 0.94402   -0.05320  22.00716  1.000 26.89050  ? 473 LEU   A O    1 
ATOM   1518 C CB   . LEU   A 1 111 ? 2.03560   -1.52716  24.51663  1.000 23.24592  ? 473 LEU   A CB   1 
ATOM   1519 C CG   . LEU   A 1 111 ? 2.85929   -1.89070  25.75321  1.000 22.78453  ? 473 LEU   A CG   1 
ATOM   1520 C CD1  . LEU   A 1 111 ? 1.90198   -2.33059  26.84521  1.000 33.54964  ? 473 LEU   A CD1  1 
ATOM   1521 C CD2  . LEU   A 1 111 ? 3.85395   -2.98882  25.43991  1.000 24.76698  ? 473 LEU   A CD2  1 
ATOM   1522 H H    . LEU   A 1 111 ? 2.62652   0.94416   23.68726  1.000 26.87020  ? 473 LEU   A H    1 
ATOM   1523 H HA   . LEU   A 1 111 ? 3.48983   -1.57129  23.06816  1.000 34.05774  ? 473 LEU   A HA   1 
ATOM   1524 H HB2  . LEU   A 1 111 ? 1.39316   -0.85868  24.80180  1.000 27.90716  ? 473 LEU   A HB2  1 
ATOM   1525 H HB3  . LEU   A 1 111 ? 1.57437   -2.33663  24.24659  1.000 27.90716  ? 473 LEU   A HB3  1 
ATOM   1526 H HG   . LEU   A 1 111 ? 3.37183   -1.12401  26.05383  1.000 27.35349  ? 473 LEU   A HG   1 
ATOM   1527 H HD11 . LEU   A 1 111 ? 2.41317   -2.58948  27.62787  1.000 40.27162  ? 473 LEU   A HD11 1 
ATOM   1528 H HD12 . LEU   A 1 111 ? 1.31237   -1.59225  27.06457  1.000 40.27162  ? 473 LEU   A HD12 1 
ATOM   1529 H HD13 . LEU   A 1 111 ? 1.38268   -3.08471  26.52499  1.000 40.27162  ? 473 LEU   A HD13 1 
ATOM   1530 H HD21 . LEU   A 1 111 ? 4.30524   -3.24901  26.25817  1.000 29.73244  ? 473 LEU   A HD21 1 
ATOM   1531 H HD22 . LEU   A 1 111 ? 3.37898   -3.74850  25.06818  1.000 29.73244  ? 473 LEU   A HD22 1 
ATOM   1532 H HD23 . LEU   A 1 111 ? 4.49991   -2.65593  24.79740  1.000 29.73244  ? 473 LEU   A HD23 1 
ATOM   1533 N N    . TYR   A 1 112 ? 1.96386   -1.87488  21.16220  1.000 26.84815  ? 474 TYR   A N    1 
ATOM   1534 C CA   . TYR   A 1 112 ? 1.14464   -1.86537  19.92745  1.000 29.04808  ? 474 TYR   A CA   1 
ATOM   1535 C C    . TYR   A 1 112 ? 1.42373   -0.51591  19.25558  1.000 26.90983  ? 474 TYR   A C    1 
ATOM   1536 O O    . TYR   A 1 112 ? 2.57893   -0.07381  19.24959  1.000 25.09692  ? 474 TYR   A O    1 
ATOM   1537 C CB   . TYR   A 1 112 ? -0.33342  -2.14305  20.23705  1.000 28.67026  ? 474 TYR   A CB   1 
ATOM   1538 C CG   . TYR   A 1 112 ? -0.53820  -3.50001  20.86725  1.000 31.75636  ? 474 TYR   A CG   1 
ATOM   1539 C CD1  . TYR   A 1 112 ? -0.60026  -4.64707  20.09117  1.000 37.14911  ? 474 TYR   A CD1  1 
ATOM   1540 C CD2  . TYR   A 1 112 ? -0.63503  -3.62725  22.23292  1.000 28.25629  ? 474 TYR   A CD2  1 
ATOM   1541 C CE1  . TYR   A 1 112 ? -0.74920  -5.90048  20.67266  1.000 37.54953  ? 474 TYR   A CE1  1 
ATOM   1542 C CE2  . TYR   A 1 112 ? -0.79119  -4.85782  22.82311  1.000 33.13045  ? 474 TYR   A CE2  1 
ATOM   1543 C CZ   . TYR   A 1 112 ? -0.84455  -5.98983  22.03921  1.000 34.75939  ? 474 TYR   A CZ   1 
ATOM   1544 O OH   . TYR   A 1 112 ? -1.01532  -7.19473  22.64470  1.000 38.91328  ? 474 TYR   A OH   1 
ATOM   1545 H H    . TYR   A 1 112 ? 2.52172   -2.52700  21.21814  1.000 32.22984  ? 474 TYR   A H    1 
ATOM   1546 H HA   . TYR   A 1 112 ? 1.44826   -2.58002  19.34609  1.000 34.86975  ? 474 TYR   A HA   1 
ATOM   1547 H HB2  . TYR   A 1 112 ? -0.66098  -1.47005  20.85404  1.000 34.41636  ? 474 TYR   A HB2  1 
ATOM   1548 H HB3  . TYR   A 1 112 ? -0.84238  -2.11244  19.41187  1.000 34.41636  ? 474 TYR   A HB3  1 
ATOM   1549 H HD1  . TYR   A 1 112 ? -0.54122  -4.57659  19.16572  1.000 44.59099  ? 474 TYR   A HD1  1 
ATOM   1550 H HD2  . TYR   A 1 112 ? -0.59406  -2.86667  22.76653  1.000 33.91961  ? 474 TYR   A HD2  1 
ATOM   1551 H HE1  . TYR   A 1 112 ? -0.78369  -6.66558  20.14508  1.000 45.07149  ? 474 TYR   A HE1  1 
ATOM   1552 H HE2  . TYR   A 1 112 ? -0.86062  -4.92665  23.74795  1.000 39.76859  ? 474 TYR   A HE2  1 
ATOM   1553 H HH   . TYR   A 1 112 ? -1.00023  -7.10153  23.47937  1.000 46.70799  ? 474 TYR   A HH   1 
ATOM   1554 N N    . ASP   A 1 113 ? 0.41534   0.16837   18.72503  1.000 27.04764  ? 475 ASP   A N    1 
ATOM   1555 C CA   . ASP   A 1 113 ? 0.59612   1.50435   18.17544  1.000 30.72687  ? 475 ASP   A CA   1 
ATOM   1556 C C    . ASP   A 1 113 ? -0.29754  2.53100   18.85519  1.000 27.27277  ? 475 ASP   A C    1 
ATOM   1557 O O    . ASP   A 1 113 ? -0.39197  3.65650   18.37442  1.000 26.57058  ? 475 ASP   A O    1 
ATOM   1558 C CB   . ASP   A 1 113 ? 0.35975   1.51861   16.65211  1.000 26.79433  ? 475 ASP   A CB   1 
ATOM   1559 C CG   . ASP   A 1 113 ? -0.95215  0.88798   16.24078  1.000 33.04353  ? 475 ASP   A CG   1 
ATOM   1560 O OD1  . ASP   A 1 113 ? -1.84701  0.71078   17.10031  1.000 28.79833  ? 475 ASP   A OD1  1 
ATOM   1561 O OD2  . ASP   A 1 113 ? -1.06743  0.57193   15.03187  1.000 35.06393  ? 475 ASP   A OD2  1 
ATOM   1562 H H    . ASP   A 1 113 ? -0.39154  -0.12443  18.67193  1.000 32.46923  ? 475 ASP   A H    1 
ATOM   1563 H HA   . ASP   A 1 113 ? 1.51850   1.76742   18.32007  1.000 36.88430  ? 475 ASP   A HA   1 
ATOM   1564 H HB2  . ASP   A 1 113 ? 0.35669   2.43836   16.34397  1.000 32.16524  ? 475 ASP   A HB2  1 
ATOM   1565 H HB3  . ASP   A 1 113 ? 1.07464   1.02612   16.21935  1.000 32.16524  ? 475 ASP   A HB3  1 
ATOM   1566 N N    . ASN   A 1 114 ? -0.91584  2.18675   19.98546  1.000 25.29762  ? 476 ASN   A N    1 
ATOM   1567 C CA   . ASN   A 1 114 ? -1.87723  3.09778   20.58967  1.000 28.48744  ? 476 ASN   A CA   1 
ATOM   1568 C C    . ASN   A 1 114 ? -1.95926  2.94345   22.10348  1.000 27.16769  ? 476 ASN   A C    1 
ATOM   1569 O O    . ASN   A 1 114 ? -2.91603  3.43237   22.69735  1.000 26.90514  ? 476 ASN   A O    1 
ATOM   1570 C CB   . ASN   A 1 114 ? -3.25617  2.85487   19.95725  1.000 36.82520  ? 476 ASN   A CB   1 
ATOM   1571 C CG   . ASN   A 1 114 ? -3.66806  1.40326   20.05482  1.000 33.23602  ? 476 ASN   A CG   1 
ATOM   1572 O OD1  . ASN   A 1 114 ? -2.84124  0.53927   20.32261  1.000 36.13142  ? 476 ASN   A OD1  1 
ATOM   1573 N ND2  . ASN   A 1 114 ? -4.93664  1.13109   19.85511  1.000 40.45308  ? 476 ASN   A ND2  1 
ATOM   1574 H H    . ASN   A 1 114 ? -0.79761  1.44851   20.41046  1.000 30.36920  ? 476 ASN   A H    1 
ATOM   1575 H HA   . ASN   A 1 114 ? -1.61408  4.01541   20.41760  1.000 34.19698  ? 476 ASN   A HA   1 
ATOM   1576 H HB2  . ASN   A 1 114 ? -3.91929  3.39119   20.41934  1.000 44.20229  ? 476 ASN   A HB2  1 
ATOM   1577 H HB3  . ASN   A 1 114 ? -3.22595  3.10034   19.01931  1.000 44.20229  ? 476 ASN   A HB3  1 
ATOM   1578 H HD21 . ASN   A 1 114 ? -5.21451  0.31852   19.90108  1.000 48.55575  ? 476 ASN   A HD21 1 
ATOM   1579 H HD22 . ASN   A 1 114 ? -5.48985  1.76536   19.67831  1.000 48.55575  ? 476 ASN   A HD22 1 
ATOM   1580 N N    . TRP   A 1 115 ? -0.98611  2.30339   22.74138  1.000 25.80564  ? 477 TRP   A N    1 
ATOM   1581 C CA   . TRP   A 1 115 ? -0.94823  2.17351   24.19047  1.000 24.75803  ? 477 TRP   A CA   1 
ATOM   1582 C C    . TRP   A 1 115 ? 0.44216   2.53206   24.70917  1.000 28.99088  ? 477 TRP   A C    1 
ATOM   1583 O O    . TRP   A 1 115 ? 1.46189   2.28431   24.05223  1.000 25.62275  ? 477 TRP   A O    1 
ATOM   1584 C CB   . TRP   A 1 115 ? -1.29114  0.74872   24.65170  1.000 25.84774  ? 477 TRP   A CB   1 
ATOM   1585 C CG   . TRP   A 1 115 ? -2.73840  0.37506   24.45950  1.000 23.57141  ? 477 TRP   A CG   1 
ATOM   1586 C CD1  . TRP   A 1 115 ? -3.28262  -0.22112  23.36464  1.000 26.64336  ? 477 TRP   A CD1  1 
ATOM   1587 C CD2  . TRP   A 1 115 ? -3.82968  0.58445   25.38354  1.000 24.46260  ? 477 TRP   A CD2  1 
ATOM   1588 N NE1  . TRP   A 1 115 ? -4.63573  -0.40993  23.54946  1.000 28.82832  ? 477 TRP   A NE1  1 
ATOM   1589 C CE2  . TRP   A 1 115 ? -4.99335  0.07108   24.77919  1.000 25.57001  ? 477 TRP   A CE2  1 
ATOM   1590 C CE3  . TRP   A 1 115 ? -3.93084  1.16014   26.65826  1.000 25.24990  ? 477 TRP   A CE3  1 
ATOM   1591 C CZ2  . TRP   A 1 115 ? -6.24112  0.11712   25.39290  1.000 28.50826  ? 477 TRP   A CZ2  1 
ATOM   1592 C CZ3  . TRP   A 1 115 ? -5.17631  1.20008   27.27893  1.000 29.65547  ? 477 TRP   A CZ3  1 
ATOM   1593 C CH2  . TRP   A 1 115 ? -6.31931  0.67765   26.63820  1.000 28.13045  ? 477 TRP   A CH2  1 
ATOM   1594 H H    . TRP   A 1 115 ? -0.32132  1.92739   22.34606  1.000 30.97882  ? 477 TRP   A H    1 
ATOM   1595 H HA   . TRP   A 1 115 ? -1.59529  2.78786   24.57098  1.000 29.72169  ? 477 TRP   A HA   1 
ATOM   1596 H HB2  . TRP   A 1 115 ? -0.75411  0.11982   24.14475  1.000 31.02934  ? 477 TRP   A HB2  1 
ATOM   1597 H HB3  . TRP   A 1 115 ? -1.08922  0.67066   25.59723  1.000 31.02934  ? 477 TRP   A HB3  1 
ATOM   1598 H HD1  . TRP   A 1 115 ? -2.81029  -0.46593  22.60182  1.000 31.98409  ? 477 TRP   A HD1  1 
ATOM   1599 H HE1  . TRP   A 1 115 ? -5.17025  -0.77260  22.98169  1.000 34.60604  ? 477 TRP   A HE1  1 
ATOM   1600 H HE3  . TRP   A 1 115 ? -3.17961  1.50887   27.08127  1.000 30.31193  ? 477 TRP   A HE3  1 
ATOM   1601 H HZ2  . TRP   A 1 115 ? -6.99704  -0.22200  24.97043  1.000 34.22197  ? 477 TRP   A HZ2  1 
ATOM   1602 H HZ3  . TRP   A 1 115 ? -5.25572  1.57562   28.12602  1.000 35.59862  ? 477 TRP   A HZ3  1 
ATOM   1603 H HH2  . TRP   A 1 115 ? -7.14176  0.71505   27.07072  1.000 33.76859  ? 477 TRP   A HH2  1 
ATOM   1604 N N    . VAL   A 1 116 ? 0.47736   3.07029   25.92219  1.000 26.35254  ? 478 VAL   A N    1 
ATOM   1605 C CA   . VAL   A 1 116 ? 1.72574   3.38755   26.60516  1.000 21.71772  ? 478 VAL   A CA   1 
ATOM   1606 C C    . VAL   A 1 116 ? 1.67762   2.75453   27.97638  1.000 23.23841  ? 478 VAL   A C    1 
ATOM   1607 O O    . VAL   A 1 116 ? 0.75275   3.00973   28.75259  1.000 29.35367  ? 478 VAL   A O    1 
ATOM   1608 C CB   . VAL   A 1 116 ? 1.94985   4.90719   26.72515  1.000 23.52611  ? 478 VAL   A CB   1 
ATOM   1609 C CG1  . VAL   A 1 116 ? 3.22001   5.20945   27.58893  1.000 22.81095  ? 478 VAL   A CG1  1 
ATOM   1610 C CG2  . VAL   A 1 116 ? 2.10457   5.48352   25.33803  1.000 25.93231  ? 478 VAL   A CG2  1 
ATOM   1611 H H    . VAL   A 1 116 ? -0.22428  3.26504   26.37975  1.000 31.63511  ? 478 VAL   A H    1 
ATOM   1612 H HA   . VAL   A 1 116 ? 2.46910   3.01036   26.10915  1.000 26.07332  ? 478 VAL   A HA   1 
ATOM   1613 H HB   . VAL   A 1 116 ? 1.19098   5.32086   27.16548  1.000 28.24339  ? 478 VAL   A HB   1 
ATOM   1614 H HG11 . VAL   A 1 116 ? 3.48936   6.12983   27.44315  1.000 27.38520  ? 478 VAL   A HG11 1 
ATOM   1615 H HG12 . VAL   A 1 116 ? 3.00551   5.07185   28.52485  1.000 27.38520  ? 478 VAL   A HG12 1 
ATOM   1616 H HG13 . VAL   A 1 116 ? 3.93384   4.60958   27.32152  1.000 27.38520  ? 478 VAL   A HG13 1 
ATOM   1617 H HG21 . VAL   A 1 116 ? 2.27499   6.43580   25.40891  1.000 31.13082  ? 478 VAL   A HG21 1 
ATOM   1618 H HG22 . VAL   A 1 116 ? 2.84889   5.04631   24.89561  1.000 31.13082  ? 478 VAL   A HG22 1 
ATOM   1619 H HG23 . VAL   A 1 116 ? 1.28689   5.33004   24.83928  1.000 31.13082  ? 478 VAL   A HG23 1 
ATOM   1620 N N    . LEU   A 1 117 ? 2.68594   1.96332   28.29065  1.000 22.57277  ? 479 LEU   A N    1 
ATOM   1621 C CA   . LEU   A 1 117 ? 2.81783   1.37568   29.60885  1.000 23.82467  ? 479 LEU   A CA   1 
ATOM   1622 C C    . LEU   A 1 117 ? 3.66538   2.31042   30.44744  1.000 22.89433  ? 479 LEU   A C    1 
ATOM   1623 O O    . LEU   A 1 117 ? 4.69578   2.79121   29.98544  1.000 18.53110  ? 479 LEU   A O    1 
ATOM   1624 C CB   . LEU   A 1 117 ? 3.45344   -0.01319  29.50770  1.000 22.75510  ? 479 LEU   A CB   1 
ATOM   1625 C CG   . LEU   A 1 117 ? 3.65113   -0.79527  30.79809  1.000 25.38560  ? 479 LEU   A CG   1 
ATOM   1626 C CD1  . LEU   A 1 117 ? 2.35168   -1.08133  31.48524  1.000 24.11666  ? 479 LEU   A CD1  1 
ATOM   1627 C CD2  . LEU   A 1 117 ? 4.42795   -2.07248  30.50757  1.000 29.98789  ? 479 LEU   A CD2  1 
ATOM   1628 H H    . LEU   A 1 117 ? 3.31768   1.74784   27.74836  1.000 27.09937  ? 479 LEU   A H    1 
ATOM   1629 H HA   . LEU   A 1 117 ? 1.95396   1.26456   30.03581  1.000 28.60166  ? 479 LEU   A HA   1 
ATOM   1630 H HB2  . LEU   A 1 117 ? 2.88909   -0.55584  28.93505  1.000 27.31817  ? 479 LEU   A HB2  1 
ATOM   1631 H HB3  . LEU   A 1 117 ? 4.33036   0.09128   29.10645  1.000 27.31817  ? 479 LEU   A HB3  1 
ATOM   1632 H HG   . LEU   A 1 117 ? 4.16668   -0.25683  31.41873  1.000 30.47477  ? 479 LEU   A HG   1 
ATOM   1633 H HD11 . LEU   A 1 117 ? 2.52281   -1.62263  32.27176  1.000 28.95205  ? 479 LEU   A HD11 1 
ATOM   1634 H HD12 . LEU   A 1 117 ? 1.94005   -0.24211  31.74443  1.000 28.95205  ? 479 LEU   A HD12 1 
ATOM   1635 H HD13 . LEU   A 1 117 ? 1.77008   -1.56023  30.87426  1.000 28.95205  ? 479 LEU   A HD13 1 
ATOM   1636 H HD21 . LEU   A 1 117 ? 4.52247   -2.57854  31.32968  1.000 35.99753  ? 479 LEU   A HD21 1 
ATOM   1637 H HD22 . LEU   A 1 117 ? 3.94160   -2.59554  29.85123  1.000 35.99753  ? 479 LEU   A HD22 1 
ATOM   1638 H HD23 . LEU   A 1 117 ? 5.30306   -1.83795  30.16104  1.000 35.99753  ? 479 LEU   A HD23 1 
ATOM   1639 N N    . THR   A 1 118 ? 3.22632   2.57878   31.66601  1.000 22.69819  ? 480 THR   A N    1 
ATOM   1640 C CA   . THR   A 1 118 ? 3.96000   3.49632   32.51394  1.000 23.98850  ? 480 THR   A CA   1 
ATOM   1641 C C    . THR   A 1 118 ? 3.70440   3.12179   33.96771  1.000 21.52785  ? 480 THR   A C    1 
ATOM   1642 O O    . THR   A 1 118 ? 3.11034   2.09446   34.26736  1.000 24.34819  ? 480 THR   A O    1 
ATOM   1643 C CB   . THR   A 1 118 ? 3.58351   4.94381   32.17648  1.000 25.03949  ? 480 THR   A CB   1 
ATOM   1644 O OG1  . THR   A 1 118 ? 4.45095   5.83081   32.88170  1.000 28.40141  ? 480 THR   A OG1  1 
ATOM   1645 C CG2  . THR   A 1 118 ? 2.11197   5.24551   32.53247  1.000 24.91770  ? 480 THR   A CG2  1 
ATOM   1646 H H    . THR   A 1 118 ? 2.51581   2.24587   32.01806  1.000 27.24988  ? 480 THR   A H    1 
ATOM   1647 H HA   . THR   A 1 118 ? 4.91436   3.40216   32.36821  1.000 28.79826  ? 480 THR   A HA   1 
ATOM   1648 H HB   . THR   A 1 118 ? 3.67914   5.08609   31.22175  1.000 30.05944  ? 480 THR   A HB   1 
ATOM   1649 H HG1  . THR   A 1 118 ? 5.22488   5.79417   32.55721  1.000 34.09374  ? 480 THR   A HG1  1 
ATOM   1650 H HG21 . THR   A 1 118 ? 1.86540   6.12517   32.20644  1.000 29.91329  ? 480 THR   A HG21 1 
ATOM   1651 H HG22 . THR   A 1 118 ? 1.53003   4.58454   32.12580  1.000 29.91329  ? 480 THR   A HG22 1 
ATOM   1652 H HG23 . THR   A 1 118 ? 1.99174   5.22132   33.49469  1.000 29.91329  ? 480 THR   A HG23 1 
ATOM   1653 N N    . ALA   A 1 119 ? 4.25689   3.91493   34.86709  1.000 24.05100  ? 481 ALA   A N    1 
ATOM   1654 C CA   . ALA   A 1 119 ? 4.05652   3.74075   36.29672  1.000 28.90132  ? 481 ALA   A CA   1 
ATOM   1655 C C    . ALA   A 1 119 ? 2.82350   4.54729   36.67659  1.000 23.67550  ? 481 ALA   A C    1 
ATOM   1656 O O    . ALA   A 1 119 ? 2.63303   5.64953   36.18138  1.000 25.21469  ? 481 ALA   A O    1 
ATOM   1657 C CB   . ALA   A 1 119 ? 5.27030   4.22731   37.10639  1.000 25.57304  ? 481 ALA   A CB   1 
ATOM   1658 H H    . ALA   A 1 119 ? 4.76613   4.57978   34.67152  1.000 28.87326  ? 481 ALA   A H    1 
ATOM   1659 H HA   . ALA   A 1 119 ? 3.93844   2.80298   36.51477  1.000 34.69364  ? 481 ALA   A HA   1 
ATOM   1660 H HB1  . ALA   A 1 119 ? 5.10414   4.07115   38.04921  1.000 30.69970  ? 481 ALA   A HB1  1 
ATOM   1661 H HB2  . ALA   A 1 119 ? 6.05670   3.73514   36.82314  1.000 30.69970  ? 481 ALA   A HB2  1 
ATOM   1662 H HB3  . ALA   A 1 119 ? 5.39771   5.17536   36.94555  1.000 30.69970  ? 481 ALA   A HB3  1 
ATOM   1663 N N    . ALA   A 1 120 ? 2.01422   4.00729   37.58446  1.000 27.22197  ? 482 ALA   A N    1 
ATOM   1664 C CA   . ALA   A 1 120 ? 0.86272   4.75377   38.07286  1.000 29.18040  ? 482 ALA   A CA   1 
ATOM   1665 C C    . ALA   A 1 120 ? 1.29777   6.03490   38.76326  1.000 30.41703  ? 482 ALA   A C    1 
ATOM   1666 O O    . ALA   A 1 120 ? 0.63010   7.07987   38.63476  1.000 27.34789  ? 482 ALA   A O    1 
ATOM   1667 C CB   . ALA   A 1 120 ? 0.05047   3.87621   39.02381  1.000 27.23534  ? 482 ALA   A CB   1 
ATOM   1668 H H    . ALA   A 1 120 ? 2.10859   3.22424   37.92728  1.000 32.67842  ? 482 ALA   A H    1 
ATOM   1669 H HA   . ALA   A 1 120 ? 0.29533   4.99588   37.32430  1.000 35.02854  ? 482 ALA   A HA   1 
ATOM   1670 H HB1  . ALA   A 1 120 ? -0.72844  4.37111   39.32258  1.000 32.69446  ? 482 ALA   A HB1  1 
ATOM   1671 H HB2  . ALA   A 1 120 ? -0.22731  3.07436   38.55394  1.000 32.69446  ? 482 ALA   A HB2  1 
ATOM   1672 H HB3  . ALA   A 1 120 ? 0.60348   3.63896   39.78459  1.000 32.69446  ? 482 ALA   A HB3  1 
ATOM   1673 N N    . HIS   A 1 121 ? 2.43375   5.98559   39.48876  1.000 23.86979  ? 483 HIS   A N    1 
ATOM   1674 C CA   . HIS   A 1 121 ? 2.82951   7.13987   40.27743  1.000 26.42137  ? 483 HIS   A CA   1 
ATOM   1675 C C    . HIS   A 1 121 ? 3.17762   8.31784   39.38569  1.000 28.80215  ? 483 HIS   A C    1 
ATOM   1676 O O    . HIS   A 1 121 ? 3.10490   9.46046   39.83429  1.000 32.95383  ? 483 HIS   A O    1 
ATOM   1677 C CB   . HIS   A 1 121 ? 4.00183   6.81070   41.22859  1.000 27.63839  ? 483 HIS   A CB   1 
ATOM   1678 C CG   . HIS   A 1 121 ? 5.35805   6.89467   40.59049  1.000 27.09530  ? 483 HIS   A CG   1 
ATOM   1679 N ND1  . HIS   A 1 121 ? 6.02313   5.78327   40.12501  1.000 28.84042  ? 483 HIS   A ND1  1 
ATOM   1680 C CD2  . HIS   A 1 121 ? 6.16931   7.95411   40.32938  1.000 28.00784  ? 483 HIS   A CD2  1 
ATOM   1681 C CE1  . HIS   A 1 121 ? 7.18036   6.14896   39.59714  1.000 31.54688  ? 483 HIS   A CE1  1 
ATOM   1682 N NE2  . HIS   A 1 121 ? 7.29077   7.46142   39.70385  1.000 31.57016  ? 483 HIS   A NE2  1 
ATOM   1683 H H    . HIS   A 1 121 ? 2.96720   5.31243   39.53208  1.000 28.65580  ? 483 HIS   A H    1 
ATOM   1684 H HA   . HIS   A 1 121 ? 2.08152   7.38782   40.84306  1.000 31.71770  ? 483 HIS   A HA   1 
ATOM   1685 H HB2  . HIS   A 1 121 ? 3.98599   7.43800   41.96828  1.000 33.17812  ? 483 HIS   A HB2  1 
ATOM   1686 H HB3  . HIS   A 1 121 ? 3.88812   5.90568   41.55861  1.000 33.17812  ? 483 HIS   A HB3  1 
ATOM   1687 H HD1  . HIS   A 1 121 ? 5.73158   4.97546   40.17020  1.000 34.62055  ? 483 HIS   A HD1  1 
ATOM   1688 H HD2  . HIS   A 1 121 ? 5.99804   8.84475   40.53513  1.000 33.62146  ? 483 HIS   A HD2  1 
ATOM   1689 H HE1  . HIS   A 1 121 ? 7.80886   5.57921   39.21600  1.000 37.86831  ? 483 HIS   A HE1  1 
ATOM   1690 N N    . ALA   A 1 122 ? 3.59769   8.04896   38.15037  1.000 25.18850  ? 484 ALA   A N    1 
ATOM   1691 C CA   . ALA   A 1 122 ? 3.96496   9.09963   37.21439  1.000 26.96112  ? 484 ALA   A CA   1 
ATOM   1692 C C    . ALA   A 1 122 ? 2.76368   9.83905   36.63547  1.000 28.01348  ? 484 ALA   A C    1 
ATOM   1693 O O    . ALA   A 1 122 ? 2.91833   10.98354  36.20598  1.000 28.94426  ? 484 ALA   A O    1 
ATOM   1694 C CB   . ALA   A 1 122 ? 4.77883   8.49401   36.07231  1.000 26.97149  ? 484 ALA   A CB   1 
ATOM   1695 H H    . ALA   A 1 122 ? 3.67911   7.25588   37.82789  1.000 30.23825  ? 484 ALA   A H    1 
ATOM   1696 H HA   . ALA   A 1 122 ? 4.50027   9.75021   37.69510  1.000 32.36540  ? 484 ALA   A HA   1 
ATOM   1697 H HB1  . ALA   A 1 122 ? 5.04386   9.20130   35.46372  1.000 32.37784  ? 484 ALA   A HB1  1 
ATOM   1698 H HB2  . ALA   A 1 122 ? 5.56561   8.06176   36.43980  1.000 32.37784  ? 484 ALA   A HB2  1 
ATOM   1699 H HB3  . ALA   A 1 122 ? 4.23178   7.84335   35.60511  1.000 32.37784  ? 484 ALA   A HB3  1 
ATOM   1700 N N    . VAL   A 1 123 ? 1.58883   9.21197   36.58047  1.000 28.31258  ? 485 VAL   A N    1 
ATOM   1701 C CA   . VAL   A 1 123 ? 0.42384   9.77862   35.91939  1.000 29.41766  ? 485 VAL   A CA   1 
ATOM   1702 C C    . VAL   A 1 123 ? -0.78863  9.88970   36.82503  1.000 32.53912  ? 485 VAL   A C    1 
ATOM   1703 O O    . VAL   A 1 123 ? -1.81343  10.42552  36.38799  1.000 31.13745  ? 485 VAL   A O    1 
ATOM   1704 C CB   . VAL   A 1 123 ? 0.04875   8.97789   34.65552  1.000 24.21237  ? 485 VAL   A CB   1 
ATOM   1705 C CG1  . VAL   A 1 123 ? 1.15505   9.12194   33.64002  1.000 30.40843  ? 485 VAL   A CG1  1 
ATOM   1706 C CG2  . VAL   A 1 123 ? -0.18244  7.48506   34.97511  1.000 26.73757  ? 485 VAL   A CG2  1 
ATOM   1707 H H    . VAL   A 1 123 ? 1.44281   8.43912   36.92829  1.000 33.98715  ? 485 VAL   A H    1 
ATOM   1708 H HA   . VAL   A 1 123 ? 0.65845   10.68052  35.65025  1.000 35.31324  ? 485 VAL   A HA   1 
ATOM   1709 H HB   . VAL   A 1 123 ? -0.78157  9.32736   34.29589  1.000 29.06690  ? 485 VAL   A HB   1 
ATOM   1710 H HG11 . VAL   A 1 123 ? 0.92465   8.61219   32.84757  1.000 36.50217  ? 485 VAL   A HG11 1 
ATOM   1711 H HG12 . VAL   A 1 123 ? 1.25492   10.05962  33.41269  1.000 36.50217  ? 485 VAL   A HG12 1 
ATOM   1712 H HG13 . VAL   A 1 123 ? 1.98031   8.78448   34.02205  1.000 36.50217  ? 485 VAL   A HG13 1 
ATOM   1713 H HG21 . VAL   A 1 123 ? -0.38584  7.01372   34.15209  1.000 32.09713  ? 485 VAL   A HG21 1 
ATOM   1714 H HG22 . VAL   A 1 123 ? 0.62193   7.11956   35.37549  1.000 32.09713  ? 485 VAL   A HG22 1 
ATOM   1715 H HG23 . VAL   A 1 123 ? -0.92526  7.40592   35.59386  1.000 32.09713  ? 485 VAL   A HG23 1 
ATOM   1716 N N    . TYR   A 1 124 ? -0.70103  9.42759   38.07741  1.000 30.71315  ? 486 TYR   A N    1 
ATOM   1717 C CA   . TYR   A 1 124 ? -1.87982  9.40143   38.93463  1.000 28.60672  ? 486 TYR   A CA   1 
ATOM   1718 C C    . TYR   A 1 124 ? -2.46973  10.79907  39.11626  1.000 35.17664  ? 486 TYR   A C    1 
ATOM   1719 O O    . TYR   A 1 124 ? -3.68990  10.97867  39.03355  1.000 33.89603  ? 486 TYR   A O    1 
ATOM   1720 C CB   . TYR   A 1 124 ? -1.51929  8.79513   40.28104  1.000 29.35944  ? 486 TYR   A CB   1 
ATOM   1721 C CG   . TYR   A 1 124 ? -2.66666  8.62766   41.24356  1.000 36.47233  ? 486 TYR   A CG   1 
ATOM   1722 C CD1  . TYR   A 1 124 ? -3.03707  9.65553   42.11170  1.000 43.39672  ? 486 TYR   A CD1  1 
ATOM   1723 C CD2  . TYR   A 1 124 ? -3.36204  7.43199   41.31494  1.000 40.21882  ? 486 TYR   A CD2  1 
ATOM   1724 C CE1  . TYR   A 1 124 ? -4.07441  9.48693   43.01373  1.000 40.88861  ? 486 TYR   A CE1  1 
ATOM   1725 C CE2  . TYR   A 1 124 ? -4.39875  7.25765   42.21220  1.000 44.82855  ? 486 TYR   A CE2  1 
ATOM   1726 C CZ   . TYR   A 1 124 ? -4.74783  8.28658   43.05410  1.000 43.88163  ? 486 TYR   A CZ   1 
ATOM   1727 O OH   . TYR   A 1 124 ? -5.78100  8.11399   43.93675  1.000 48.03248  ? 486 TYR   A OH   1 
ATOM   1728 H H    . TYR   A 1 124 ? 0.01744   9.12987   38.44451  1.000 36.86784  ? 486 TYR   A H    1 
ATOM   1729 H HA   . TYR   A 1 124 ? -2.55816  8.84577   38.51991  1.000 34.34012  ? 486 TYR   A HA   1 
ATOM   1730 H HB2  . TYR   A 1 124 ? -1.13982  7.91565   40.12807  1.000 35.24338  ? 486 TYR   A HB2  1 
ATOM   1731 H HB3  . TYR   A 1 124 ? -0.86472  9.36905   40.70889  1.000 35.24338  ? 486 TYR   A HB3  1 
ATOM   1732 H HD1  . TYR   A 1 124 ? -2.58078  10.46543  42.08415  1.000 52.08812  ? 486 TYR   A HD1  1 
ATOM   1733 H HD2  . TYR   A 1 124 ? -3.12689  6.73306   40.74828  1.000 48.27464  ? 486 TYR   A HD2  1 
ATOM   1734 H HE1  . TYR   A 1 124 ? -4.31411  10.17862  43.58733  1.000 49.07839  ? 486 TYR   A HE1  1 
ATOM   1735 H HE2  . TYR   A 1 124 ? -4.85727  6.44925   42.24611  1.000 53.80632  ? 486 TYR   A HE2  1 
ATOM   1736 H HH   . TYR   A 1 124 ? -6.08863  7.33518   43.87023  1.000 57.65102  ? 486 TYR   A HH   1 
ATOM   1737 N N    . GLU   A 1 125 ? -1.62597  11.79969  39.35011  1.000 38.34103  ? 487 GLU   A N    1 
ATOM   1738 C CA   . GLU   A 1 125 ? -2.16502  13.10885  39.69738  1.000 41.26162  ? 487 GLU   A CA   1 
ATOM   1739 C C    . GLU   A 1 125 ? -2.78506  13.77130  38.47978  1.000 39.69379  ? 487 GLU   A C    1 
ATOM   1740 O O    . GLU   A 1 125 ? -3.86629  14.35082  38.57068  1.000 38.41480  ? 487 GLU   A O    1 
ATOM   1741 C CB   . GLU   A 1 125 ? -1.08033  13.97522  40.32791  1.000 40.08222  ? 487 GLU   A CB   1 
ATOM   1742 C CG   . GLU   A 1 125 ? -1.03514  13.75762  41.87353  1.000 50.68953  ? 487 GLU   A CG   1 
ATOM   1743 C CD   . GLU   A 1 125 ? 0.31602   14.06470  42.48867  1.000 55.71483  ? 487 GLU   A CD   1 
ATOM   1744 O OE1  . GLU   A 1 125 ? 0.47096   13.94493  43.73449  1.000 57.26221  ? 487 GLU   A OE1  1 
ATOM   1745 O OE2  . GLU   A 1 125 ? 1.19768   14.50259  41.71934  1.000 56.27481  ? 487 GLU   A OE2  1 
ATOM   1746 H H    . GLU   A 1 125 ? -0.76816  11.74905  39.31563  1.000 46.02129  ? 487 GLU   A H    1 
ATOM   1747 H HA   . GLU   A 1 125 ? -2.86297  13.00781  40.36338  1.000 49.52600  ? 487 GLU   A HA   1 
ATOM   1748 H HB2  . GLU   A 1 125 ? -0.21709  13.73562  39.95602  1.000 48.11072  ? 487 GLU   A HB2  1 
ATOM   1749 H HB3  . GLU   A 1 125 ? -1.26931  14.91026  40.15215  1.000 48.11072  ? 487 GLU   A HB3  1 
ATOM   1750 H HG2  . GLU   A 1 125 ? -1.69008  14.33883  42.29086  1.000 60.83949  ? 487 GLU   A HG2  1 
ATOM   1751 H HG3  . GLU   A 1 125 ? -1.24458  12.83015  42.06543  1.000 60.83949  ? 487 GLU   A HG3  1 
ATOM   1752 N N    . GLN   A 1 126 ? -2.14775  13.63824  37.32021  1.000 39.62005  ? 488 GLN   A N    1 
ATOM   1753 C CA   . GLN   A 1 126 ? -2.72293  14.19381  36.10492  1.000 45.94734  ? 488 GLN   A CA   1 
ATOM   1754 C C    . GLN   A 1 126 ? -3.99371  13.44719  35.70524  1.000 41.77795  ? 488 GLN   A C    1 
ATOM   1755 O O    . GLN   A 1 126 ? -4.93763  14.06131  35.20918  1.000 40.69616  ? 488 GLN   A O    1 
ATOM   1756 C CB   . GLN   A 1 126 ? -1.69015  14.16560  34.97355  1.000 47.32735  ? 488 GLN   A CB   1 
ATOM   1757 C CG   . GLN   A 1 126 ? -1.03668  15.51563  34.69056  1.000 62.40641  ? 488 GLN   A CG   1 
ATOM   1758 C CD   . GLN   A 1 126 ? -0.40115  15.59840  33.30724  1.000 73.66572  ? 488 GLN   A CD   1 
ATOM   1759 O OE1  . GLN   A 1 126 ? 0.79634   15.35117  33.14699  1.000 72.22948  ? 488 GLN   A OE1  1 
ATOM   1760 N NE2  . GLN   A 1 126 ? -1.20055  15.95189  32.30223  1.000 57.27120  ? 488 GLN   A NE2  1 
ATOM   1761 H H    . GLN   A 1 126 ? -1.39433  13.23762  37.21316  1.000 47.55612  ? 488 GLN   A H    1 
ATOM   1762 H HA   . GLN   A 1 126 ? -2.95943  15.12212  36.25724  1.000 55.14886  ? 488 GLN   A HA   1 
ATOM   1763 H HB2  . GLN   A 1 126 ? -0.98636  13.54191  35.21142  1.000 56.80488  ? 488 GLN   A HB2  1 
ATOM   1764 H HB3  . GLN   A 1 126 ? -2.12985  13.87486  34.15928  1.000 56.80488  ? 488 GLN   A HB3  1 
ATOM   1765 H HG2  . GLN   A 1 126 ? -1.71135  16.20999  34.75040  1.000 74.89975  ? 488 GLN   A HG2  1 
ATOM   1766 H HG3  . GLN   A 1 126 ? -0.34069  15.67177  35.34792  1.000 74.89975  ? 488 GLN   A HG3  1 
ATOM   1767 H HE21 . GLN   A 1 126 ? -2.03060  16.12005  32.45173  1.000 68.73749  ? 488 GLN   A HE21 1 
ATOM   1768 H HE22 . GLN   A 1 126 ? -0.88666  16.01197  31.50381  1.000 68.73749  ? 488 GLN   A HE22 1 
ATOM   1769 N N    . LYS   A 1 127 ? -4.05122  12.13386  35.94034  1.000 35.45603  ? 489 LYS   A N    1 
ATOM   1770 C CA   . LYS   A 1 127 ? -5.27108  11.37913  35.66725  1.000 37.45491  ? 489 LYS   A CA   1 
ATOM   1771 C C    . LYS   A 1 127 ? -6.43054  11.91458  36.48694  1.000 42.69842  ? 489 LYS   A C    1 
ATOM   1772 O O    . LYS   A 1 127 ? -7.51090  12.18931  35.95724  1.000 43.51429  ? 489 LYS   A O    1 
ATOM   1773 C CB   . LYS   A 1 127 ? -5.06255  9.89184   35.98226  1.000 38.86789  ? 489 LYS   A CB   1 
ATOM   1774 C CG   . LYS   A 1 127 ? -6.23381  9.00762   35.60251  1.000 40.13250  ? 489 LYS   A CG   1 
ATOM   1775 C CD   . LYS   A 1 127 ? -7.16825  8.66053   36.75589  1.000 44.04273  ? 489 LYS   A CD   1 
ATOM   1776 C CE   . LYS   A 1 127 ? -7.88289  7.30114   36.51702  1.000 49.66988  ? 489 LYS   A CE   1 
ATOM   1777 N NZ   . LYS   A 1 127 ? -8.97422  7.39838   35.51663  1.000 54.32525  ? 489 LYS   A NZ   1 
ATOM   1778 H H    . LYS   A 1 127 ? -3.40402  11.66259  36.25440  1.000 42.55929  ? 489 LYS   A H    1 
ATOM   1779 H HA   . LYS   A 1 127 ? -5.47986  11.46731  34.72410  1.000 44.95794  ? 489 LYS   A HA   1 
ATOM   1780 H HB2  . LYS   A 1 127 ? -4.28560  9.57722   35.49414  1.000 46.65353  ? 489 LYS   A HB2  1 
ATOM   1781 H HB3  . LYS   A 1 127 ? -4.91694  9.79415   36.93628  1.000 46.65353  ? 489 LYS   A HB3  1 
ATOM   1782 H HG2  . LYS   A 1 127 ? -6.76041  9.46461   34.92815  1.000 48.17106  ? 489 LYS   A HG2  1 
ATOM   1783 H HG3  . LYS   A 1 127 ? -5.88911  8.17409   35.24569  1.000 48.17106  ? 489 LYS   A HG3  1 
ATOM   1784 H HD2  . LYS   A 1 127 ? -6.65574  8.59591   37.57690  1.000 52.86333  ? 489 LYS   A HD2  1 
ATOM   1785 H HD3  . LYS   A 1 127 ? -7.84484  9.35042   36.84058  1.000 52.86333  ? 489 LYS   A HD3  1 
ATOM   1786 H HE2  . LYS   A 1 127 ? -7.23548  6.65537   36.19338  1.000 59.61592  ? 489 LYS   A HE2  1 
ATOM   1787 H HE3  . LYS   A 1 127 ? -8.26805  6.99447   37.35278  1.000 59.61592  ? 489 LYS   A HE3  1 
ATOM   1788 H HZ1  . LYS   A 1 127 ? -9.36283  6.60458   35.41196  1.000 65.20235  ? 489 LYS   A HZ1  1 
ATOM   1789 H HZ2  . LYS   A 1 127 ? -9.58524  7.98546   35.78882  1.000 65.20235  ? 489 LYS   A HZ2  1 
ATOM   1790 H HZ3  . LYS   A 1 127 ? -8.64629  7.66496   34.73337  1.000 65.20235  ? 489 LYS   A HZ3  1 
ATOM   1791 N N    . HIS   A 1 128 ? -6.21131  12.09241  37.78685  1.000 38.25644  ? 490 HIS   A N    1 
ATOM   1792 C CA   . HIS   A 1 128 ? -7.31634  12.34077  38.69780  1.000 40.83343  ? 490 HIS   A CA   1 
ATOM   1793 C C    . HIS   A 1 128 ? -7.71282  13.80097  38.76013  1.000 44.84447  ? 490 HIS   A C    1 
ATOM   1794 O O    . HIS   A 1 128 ? -8.61669  14.13774  39.53344  1.000 51.93354  ? 490 HIS   A O    1 
ATOM   1795 C CB   . HIS   A 1 128 ? -6.98401  11.79305  40.08154  1.000 42.72987  ? 490 HIS   A CB   1 
ATOM   1796 C CG   . HIS   A 1 128 ? -7.35609  10.35272  40.22866  1.000 46.22256  ? 490 HIS   A CG   1 
ATOM   1797 N ND1  . HIS   A 1 128 ? -6.42521  9.35297   40.39829  1.000 50.00528  ? 490 HIS   A ND1  1 
ATOM   1798 C CD2  . HIS   A 1 128 ? -8.56096  9.73809   40.16670  1.000 46.84727  ? 490 HIS   A CD2  1 
ATOM   1799 C CE1  . HIS   A 1 128 ? -7.04333  8.18576   40.45999  1.000 49.65270  ? 490 HIS   A CE1  1 
ATOM   1800 N NE2  . HIS   A 1 128 ? -8.33932  8.39356   40.32185  1.000 46.61449  ? 490 HIS   A NE2  1 
ATOM   1801 H H    . HIS   A 1 128 ? -5.43652  12.07342  38.15959  1.000 45.91978  ? 490 HIS   A H    1 
ATOM   1802 H HA   . HIS   A 1 128 ? -8.09898  11.85739  38.39005  1.000 49.01217  ? 490 HIS   A HA   1 
ATOM   1803 H HB2  . HIS   A 1 128 ? -6.02967  11.87533  40.23435  1.000 51.28790  ? 490 HIS   A HB2  1 
ATOM   1804 H HB3  . HIS   A 1 128 ? -7.47183  12.30045  40.74898  1.000 51.28790  ? 490 HIS   A HB3  1 
ATOM   1805 H HD2  . HIS   A 1 128 ? -9.38508  10.15068  40.04217  1.000 56.22877  ? 490 HIS   A HD2  1 
ATOM   1806 H HE1  . HIS   A 1 128 ? -6.63449  7.35914   40.58025  1.000 59.59530  ? 490 HIS   A HE1  1 
ATOM   1807 H HE2  . HIS   A 1 128 ? -8.94648  7.78452   40.32811  1.000 55.94944  ? 490 HIS   A HE2  1 
ATOM   1808 N N    . ASP   A 1 129 ? -7.10481  14.66491  37.94349  1.000 37.94700  ? 491 ASP   A N    1 
ATOM   1809 C CA   . ASP   A 1 129 ? -7.76016  15.92287  37.61227  1.000 50.82761  ? 491 ASP   A CA   1 
ATOM   1810 C C    . ASP   A 1 129 ? -7.95457  16.08051  36.10543  1.000 43.76205  ? 491 ASP   A C    1 
ATOM   1811 O O    . ASP   A 1 129 ? -8.01398  17.20113  35.59351  1.000 37.87949  ? 491 ASP   A O    1 
ATOM   1812 C CB   . ASP   A 1 129 ? -7.04518  17.12262  38.23064  1.000 55.52401  ? 491 ASP   A CB   1 
ATOM   1813 C CG   . ASP   A 1 129 ? -5.57161  17.08484  38.09660  1.000 57.32696  ? 491 ASP   A CG   1 
ATOM   1814 O OD1  . ASP   A 1 129 ? -5.08410  17.01321  36.95229  1.000 63.76974  ? 491 ASP   A OD1  1 
ATOM   1815 O OD2  . ASP   A 1 129 ? -4.90987  17.23262  39.14245  1.000 51.57365  ? 491 ASP   A OD2  1 
ATOM   1816 H H    . ASP   A 1 129 ? -6.33420  14.54374  37.58144  1.000 45.54846  ? 491 ASP   A H    1 
ATOM   1817 H HA   . ASP   A 1 129 ? -8.64580  15.91054  38.00774  1.000 61.00518  ? 491 ASP   A HA   1 
ATOM   1818 H HB2  . ASP   A 1 129 ? -7.35940  17.93013  37.79463  1.000 66.64087  ? 491 ASP   A HB2  1 
ATOM   1819 H HB3  . ASP   A 1 129 ? -7.25350  17.15428  39.17747  1.000 66.64087  ? 491 ASP   A HB3  1 
ATOM   1820 N N    . ALA   A 1 130 ? -8.13390  14.95198  35.41172  1.000 44.82073  ? 492 ALA   A N    1 
ATOM   1821 C CA   . ALA   A 1 130 ? -8.74640  14.90672  34.08262  1.000 43.78607  ? 492 ALA   A CA   1 
ATOM   1822 C C    . ALA   A 1 130 ? -8.03475  15.81412  33.08383  1.000 47.40822  ? 492 ALA   A C    1 
ATOM   1823 O O    . ALA   A 1 130 ? -8.66689  16.42536  32.21789  1.000 44.75555  ? 492 ALA   A O    1 
ATOM   1824 C CB   . ALA   A 1 130 ? -10.22933 15.27033  34.16842  1.000 42.65953  ? 492 ALA   A CB   1 
ATOM   1825 H H    . ALA   A 1 130 ? -7.90122  14.17584  35.69995  1.000 53.79693  ? 492 ALA   A H    1 
ATOM   1826 H HA   . ALA   A 1 130 ? -8.66487  14.00232  33.74158  1.000 52.55534  ? 492 ALA   A HA   1 
ATOM   1827 H HB1  . ALA   A 1 130 ? -10.63047 15.16957  33.29101  1.000 51.20349  ? 492 ALA   A HB1  1 
ATOM   1828 H HB2  . ALA   A 1 130 ? -10.66389 14.67703  34.80091  1.000 51.20349  ? 492 ALA   A HB2  1 
ATOM   1829 H HB3  . ALA   A 1 130 ? -10.31234 16.18966  34.46647  1.000 51.20349  ? 492 ALA   A HB3  1 
ATOM   1830 N N    . SER   A 1 131 ? -6.72421  15.94443  33.22535  1.000 42.84052  ? 493 SER   A N    1 
ATOM   1831 C CA   . SER   A 1 131 ? -5.89937  16.67646  32.27783  1.000 47.98147  ? 493 SER   A CA   1 
ATOM   1832 C C    . SER   A 1 131 ? -5.25627  15.64323  31.36680  1.000 43.75676  ? 493 SER   A C    1 
ATOM   1833 O O    . SER   A 1 131 ? -4.60617  14.71266  31.85626  1.000 36.78000  ? 493 SER   A O    1 
ATOM   1834 C CB   . SER   A 1 131 ? -4.83941  17.50546  33.00164  1.000 52.67247  ? 493 SER   A CB   1 
ATOM   1835 O OG   . SER   A 1 131 ? -5.38048  18.14232  34.14794  1.000 57.95144  ? 493 SER   A OG   1 
ATOM   1836 H H    . SER   A 1 131 ? -6.27835  15.60868  33.87963  1.000 51.42067  ? 493 SER   A H    1 
ATOM   1837 H HA   . SER   A 1 131 ? -6.43484  17.29051  31.75140  1.000 57.58982  ? 493 SER   A HA   1 
ATOM   1838 H HB2  . SER   A 1 131 ? -4.11755  16.91979  33.27880  1.000 63.21901  ? 493 SER   A HB2  1 
ATOM   1839 H HB3  . SER   A 1 131 ? -4.50237  18.18333  32.39518  1.000 63.21901  ? 493 SER   A HB3  1 
ATOM   1840 H HG   . SER   A 1 131 ? -4.78665  18.59571  34.53188  1.000 69.55378  ? 493 SER   A HG   1 
ATOM   1841 N N    . ALA   A 1 132 ? -5.48093  15.77550  30.06315  1.000 39.69611  ? 494 ALA   A N    1 
ATOM   1842 C CA   . ALA   A 1 132 ? -4.90719  14.83836  29.11686  1.000 41.80673  ? 494 ALA   A CA   1 
ATOM   1843 C C    . ALA   A 1 132 ? -3.38453  14.88673  29.19664  1.000 45.56453  ? 494 ALA   A C    1 
ATOM   1844 O O    . ALA   A 1 132 ? -2.77847  15.93290  29.45608  1.000 42.68256  ? 494 ALA   A O    1 
ATOM   1845 C CB   . ALA   A 1 132 ? -5.38926  15.14807  27.69818  1.000 46.42674  ? 494 ALA   A CB   1 
ATOM   1846 H H    . ALA   A 1 132 ? -5.95881  16.39570  29.70736  1.000 47.64738  ? 494 ALA   A H    1 
ATOM   1847 H HA   . ALA   A 1 132 ? -5.19303  13.93569  29.32755  1.000 50.18013  ? 494 ALA   A HA   1 
ATOM   1848 H HB1  . ALA   A 1 132 ? -4.99061  14.51247  27.08337  1.000 55.72414  ? 494 ALA   A HB1  1 
ATOM   1849 H HB2  . ALA   A 1 132 ? -6.35601  15.07387  27.66990  1.000 55.72414  ? 494 ALA   A HB2  1 
ATOM   1850 H HB3  . ALA   A 1 132 ? -5.11968  16.04963  27.46281  1.000 55.72414  ? 494 ALA   A HB3  1 
ATOM   1851 N N    . LEU   A 1 133 ? -2.76761  13.72474  28.99970  1.000 32.26951  ? 495 LEU   A N    1 
ATOM   1852 C CA   . LEU   A 1 133 ? -1.31686  13.60191  29.08483  1.000 37.96376  ? 495 LEU   A CA   1 
ATOM   1853 C C    . LEU   A 1 133 ? -0.68368  13.99493  27.75646  1.000 29.97509  ? 495 LEU   A C    1 
ATOM   1854 O O    . LEU   A 1 133 ? -1.16144  13.60000  26.68992  1.000 34.34261  ? 495 LEU   A O    1 
ATOM   1855 C CB   . LEU   A 1 133 ? -0.93665  12.16534  29.43903  1.000 32.11761  ? 495 LEU   A CB   1 
ATOM   1856 C CG   . LEU   A 1 133 ? -1.40486  11.65953  30.80310  1.000 36.65147  ? 495 LEU   A CG   1 
ATOM   1857 C CD1  . LEU   A 1 133 ? -1.18325  10.15768  30.90823  1.000 33.89128  ? 495 LEU   A CD1  1 
ATOM   1858 C CD2  . LEU   A 1 133 ? -0.63646  12.38742  31.91628  1.000 35.72864  ? 495 LEU   A CD2  1 
ATOM   1859 H H    . LEU   A 1 133 ? -3.17004  12.98772  28.81409  1.000 38.73547  ? 495 LEU   A H    1 
ATOM   1860 H HA   . LEU   A 1 133 ? -0.97836  14.19359  29.77491  1.000 45.56856  ? 495 LEU   A HA   1 
ATOM   1861 H HB2  . LEU   A 1 133 ? -1.32004  11.57804  28.76897  1.000 38.55319  ? 495 LEU   A HB2  1 
ATOM   1862 H HB3  . LEU   A 1 133 ? 0.03087   12.09740  29.42526  1.000 38.55319  ? 495 LEU   A HB3  1 
ATOM   1863 H HG   . LEU   A 1 133 ? -2.35251  11.83682  30.91005  1.000 43.99382  ? 495 LEU   A HG   1 
ATOM   1864 H HD11 . LEU   A 1 133 ? -1.49923  9.85159   31.77274  1.000 40.68159  ? 495 LEU   A HD11 1 
ATOM   1865 H HD12 . LEU   A 1 133 ? -1.67685  9.71528   30.20004  1.000 40.68159  ? 495 LEU   A HD12 1 
ATOM   1866 H HD13 . LEU   A 1 133 ? -0.23570  9.97115   30.81738  1.000 40.68159  ? 495 LEU   A HD13 1 
ATOM   1867 H HD21 . LEU   A 1 133 ? -0.89941  12.01923  32.77430  1.000 42.88642  ? 495 LEU   A HD21 1 
ATOM   1868 H HD22 . LEU   A 1 133 ? 0.31518   12.25923  31.77896  1.000 42.88642  ? 495 LEU   A HD22 1 
ATOM   1869 H HD23 . LEU   A 1 133 ? -0.85120  13.33273  31.88216  1.000 42.88642  ? 495 LEU   A HD23 1 
ATOM   1870 N N    . ASP   A 1 134 ? 0.36906   14.78792  27.82597  1.000 32.90150  ? 496 ASP   A N    1 
ATOM   1871 C CA   . ASP   A 1 134 ? 1.15252   15.18635  26.66358  1.000 34.41591  ? 496 ASP   A CA   1 
ATOM   1872 C C    . ASP   A 1 134 ? 2.22871   14.12153  26.45895  1.000 37.13585  ? 496 ASP   A C    1 
ATOM   1873 O O    . ASP   A 1 134 ? 3.19472   14.04852  27.21997  1.000 34.83324  ? 496 ASP   A O    1 
ATOM   1874 C CB   . ASP   A 1 134 ? 1.76746   16.57514  26.87355  1.000 38.89580  ? 496 ASP   A CB   1 
ATOM   1875 C CG   . ASP   A 1 134 ? 2.41904   17.14681  25.60127  1.000 43.40717  ? 496 ASP   A CG   1 
ATOM   1876 O OD1  . ASP   A 1 134 ? 2.89384   16.38231  24.72542  1.000 39.00187  ? 496 ASP   A OD1  1 
ATOM   1877 O OD2  . ASP   A 1 134 ? 2.44450   18.38641  25.46679  1.000 51.68869  ? 496 ASP   A OD2  1 
ATOM   1878 H H    . ASP   A 1 134 ? 0.66383   15.12298  28.56112  1.000 39.49385  ? 496 ASP   A H    1 
ATOM   1879 H HA   . ASP   A 1 134 ? 0.59094   15.23137  25.87396  1.000 41.31115  ? 496 ASP   A HA   1 
ATOM   1880 H HB2  . ASP   A 1 134 ? 1.07036   17.18889  27.15330  1.000 46.68701  ? 496 ASP   A HB2  1 
ATOM   1881 H HB3  . ASP   A 1 134 ? 2.45183   16.51595  27.55842  1.000 46.68701  ? 496 ASP   A HB3  1 
ATOM   1882 N N    . ILE   A 1 135 ? 2.08095   13.33363  25.40837  1.000 29.72558  ? 497 ILE   A N    1 
ATOM   1883 C CA   . ILE   A 1 135 ? 2.89556   12.14897  25.17642  1.000 28.95664  ? 497 ILE   A CA   1 
ATOM   1884 C C    . ILE   A 1 135 ? 3.68281   12.39660  23.90191  1.000 30.83925  ? 497 ILE   A C    1 
ATOM   1885 O O    . ILE   A 1 135 ? 3.10868   12.77630  22.87337  1.000 31.68543  ? 497 ILE   A O    1 
ATOM   1886 C CB   . ILE   A 1 135 ? 2.00893   10.88815  25.07221  1.000 33.96155  ? 497 ILE   A CB   1 
ATOM   1887 C CG1  . ILE   A 1 135 ? 1.47923   10.52165  26.46083  1.000 34.72355  ? 497 ILE   A CG1  1 
ATOM   1888 C CG2  . ILE   A 1 135 ? 2.76645   9.74380   24.45975  1.000 32.22058  ? 497 ILE   A CG2  1 
ATOM   1889 C CD1  . ILE   A 1 135 ? 0.19200   9.75422   26.43186  1.000 33.35006  ? 497 ILE   A CD1  1 
ATOM   1890 H H    . ILE   A 1 135 ? 1.49530   13.46754  24.79300  1.000 35.68275  ? 497 ILE   A H    1 
ATOM   1891 H HA   . ILE   A 1 135 ? 3.52608   12.00839  25.90001  1.000 34.76003  ? 497 ILE   A HA   1 
ATOM   1892 H HB   . ILE   A 1 135 ? 1.25743   11.08102  24.49003  1.000 40.76591  ? 497 ILE   A HB   1 
ATOM   1893 H HG12 . ILE   A 1 135 ? 2.14040   9.97417   26.91252  1.000 41.68031  ? 497 ILE   A HG12 1 
ATOM   1894 H HG13 . ILE   A 1 135 ? 1.32619   11.33800  26.96188  1.000 41.68031  ? 497 ILE   A HG13 1 
ATOM   1895 H HG21 . ILE   A 1 135 ? 2.31420   8.91357   24.67673  1.000 38.67675  ? 497 ILE   A HG21 1 
ATOM   1896 H HG22 . ILE   A 1 135 ? 2.79524   9.86311   23.49754  1.000 38.67675  ? 497 ILE   A HG22 1 
ATOM   1897 H HG23 . ILE   A 1 135 ? 3.66746   9.73331   24.81886  1.000 38.67675  ? 497 ILE   A HG23 1 
ATOM   1898 H HD11 . ILE   A 1 135 ? -0.11787  9.62282   27.34159  1.000 40.03213  ? 497 ILE   A HD11 1 
ATOM   1899 H HD12 . ILE   A 1 135 ? -0.46544  10.25916  25.92816  1.000 40.03213  ? 497 ILE   A HD12 1 
ATOM   1900 H HD13 . ILE   A 1 135 ? 0.34571   8.89561   26.00751  1.000 40.03213  ? 497 ILE   A HD13 1 
ATOM   1901 N N    . ARG   A 1 136 ? 4.97807   12.19225  23.97025  1.000 28.44156  ? 498 ARG   A N    1 
ATOM   1902 C CA   . ARG   A 1 136 ? 5.88803   12.50568  22.88113  1.000 25.64392  ? 498 ARG   A CA   1 
ATOM   1903 C C    . ARG   A 1 136 ? 6.81067   11.32681  22.63463  1.000 30.32797  ? 498 ARG   A C    1 
ATOM   1904 O O    . ARG   A 1 136 ? 7.21884   10.62529  23.57399  1.000 26.63950  ? 498 ARG   A O    1 
ATOM   1905 C CB   . ARG   A 1 136 ? 6.70950   13.75858  23.21231  1.000 26.86595  ? 498 ARG   A CB   1 
ATOM   1906 C CG   . ARG   A 1 136 ? 5.82864   14.95050  23.60099  1.000 37.25452  ? 498 ARG   A CG   1 
ATOM   1907 C CD   . ARG   A 1 136 ? 6.60055   16.20752  23.91783  1.000 27.63907  ? 498 ARG   A CD   1 
ATOM   1908 N NE   . ARG   A 1 136 ? 5.72681   17.32912  24.28778  1.000 34.22395  ? 498 ARG   A NE   1 
ATOM   1909 C CZ   . ARG   A 1 136 ? 6.13773   18.58221  24.46853  1.000 35.28472  ? 498 ARG   A CZ   1 
ATOM   1910 N NH1  . ARG   A 1 136 ? 7.39561   18.92854  24.27182  1.000 28.37588  ? 498 ARG   A NH1  1 
ATOM   1911 N NH2  . ARG   A 1 136 ? 5.26906   19.50163  24.88377  1.000 31.87411  ? 498 ARG   A NH2  1 
ATOM   1912 H H    . ARG   A 1 136 ? 5.37288   11.86154  24.65898  1.000 34.14192  ? 498 ARG   A H    1 
ATOM   1913 H HA   . ARG   A 1 136 ? 5.38918   12.66742  22.06510  1.000 30.78475  ? 498 ARG   A HA   1 
ATOM   1914 H HB2  . ARG   A 1 136 ? 7.29865   13.56319  23.95771  1.000 32.25120  ? 498 ARG   A HB2  1 
ATOM   1915 H HB3  . ARG   A 1 136 ? 7.23118   14.01014  22.43420  1.000 32.25120  ? 498 ARG   A HB3  1 
ATOM   1916 H HG2  . ARG   A 1 136 ? 5.23139   15.15025  22.86323  1.000 44.71748  ? 498 ARG   A HG2  1 
ATOM   1917 H HG3  . ARG   A 1 136 ? 5.31489   14.71436  24.38915  1.000 44.71748  ? 498 ARG   A HG3  1 
ATOM   1918 H HD2  . ARG   A 1 136 ? 7.19743   16.03355  24.66239  1.000 33.17894  ? 498 ARG   A HD2  1 
ATOM   1919 H HD3  . ARG   A 1 136 ? 7.11225   16.47038  23.13683  1.000 33.17894  ? 498 ARG   A HD3  1 
ATOM   1920 H HE   . ARG   A 1 136 ? 4.88964   17.16422  24.39529  1.000 41.08080  ? 498 ARG   A HE   1 
ATOM   1921 H HH11 . ARG   A 1 136 ? 7.96974   18.33925  24.02141  1.000 34.06311  ? 498 ARG   A HH11 1 
ATOM   1922 H HH12 . ARG   A 1 136 ? 7.64135   19.74358  24.39402  1.000 34.06311  ? 498 ARG   A HH12 1 
ATOM   1923 H HH21 . ARG   A 1 136 ? 4.45059   19.28368  25.03274  1.000 38.26098  ? 498 ARG   A HH21 1 
ATOM   1924 H HH22 . ARG   A 1 136 ? 5.52639   20.31352  25.00303  1.000 38.26098  ? 498 ARG   A HH22 1 
ATOM   1925 N N    . MET   A 1 137 ? 7.14356   11.11151  21.37079  1.000 27.45907  ? 499 MET   A N    1 
ATOM   1926 C CA   . MET   A 1 137 ? 7.99637   9.97684   21.03841  1.000 28.47405  ? 499 MET   A CA   1 
ATOM   1927 C C    . MET   A 1 137 ? 8.68045   10.24665  19.70280  1.000 30.04939  ? 499 MET   A C    1 
ATOM   1928 O O    . MET   A 1 137 ? 8.58058   11.33937  19.12692  1.000 28.72724  ? 499 MET   A O    1 
ATOM   1929 C CB   . MET   A 1 137 ? 7.19749   8.66835   21.06302  1.000 28.16780  ? 499 MET   A CB   1 
ATOM   1930 C CG   . MET   A 1 137 ? 6.05577   8.56308   20.12127  1.000 34.32101  ? 499 MET   A CG   1 
ATOM   1931 S SD   . MET   A 1 137 ? 5.10107   7.06995   20.52761  1.000 46.09645  ? 499 MET   A SD   1 
ATOM   1932 C CE   . MET   A 1 137 ? 3.67366   7.73502   21.35285  1.000 47.64786  ? 499 MET   A CE   1 
ATOM   1933 H H    . MET   A 1 137 ? 6.89558   11.59469  20.70398  1.000 32.96294  ? 499 MET   A H    1 
ATOM   1934 H HA   . MET   A 1 137 ? 8.69607   9.89731   21.70550  1.000 34.18092  ? 499 MET   A HA   1 
ATOM   1935 H HB2  . MET   A 1 137 ? 7.80522   7.94203   20.85319  1.000 33.81341  ? 499 MET   A HB2  1 
ATOM   1936 H HB3  . MET   A 1 137 ? 6.83861   8.55294   21.95677  1.000 33.81341  ? 499 MET   A HB3  1 
ATOM   1937 H HG2  . MET   A 1 137 ? 5.48149   9.33996   20.20830  1.000 41.19726  ? 499 MET   A HG2  1 
ATOM   1938 H HG3  . MET   A 1 137 ? 6.38251   8.49238   19.21070  1.000 41.19726  ? 499 MET   A HG3  1 
ATOM   1939 H HE1  . MET   A 1 137 ? 3.01889   7.02895   21.46968  1.000 57.18949  ? 499 MET   A HE1  1 
ATOM   1940 H HE2  . MET   A 1 137 ? 3.94239   8.08328   22.21737  1.000 57.18949  ? 499 MET   A HE2  1 
ATOM   1941 H HE3  . MET   A 1 137 ? 3.29904   8.44723   20.81126  1.000 57.18949  ? 499 MET   A HE3  1 
ATOM   1942 N N    . GLY   A 1 138 ? 9.47488   9.27651   19.27513  1.000 30.86252  ? 500 GLY   A N    1 
ATOM   1943 C CA   . GLY   A 1 138 ? 10.31575  9.42596   18.11120  1.000 27.64334  ? 500 GLY   A CA   1 
ATOM   1944 C C    . GLY   A 1 138 ? 11.46363  10.38160  18.28766  1.000 38.22842  ? 500 GLY   A C    1 
ATOM   1945 O O    . GLY   A 1 138 ? 12.06195  10.78800  17.29126  1.000 36.89895  ? 500 GLY   A O    1 
ATOM   1946 H H    . GLY   A 1 138 ? 9.54378   8.50683   19.65255  1.000 37.04708  ? 500 GLY   A H    1 
ATOM   1947 H HA2  . GLY   A 1 138 ? 10.68397  8.55908   17.87915  1.000 33.18406  ? 500 GLY   A HA2  1 
ATOM   1948 H HA3  . GLY   A 1 138 ? 9.77326   9.74632   17.37366  1.000 33.18406  ? 500 GLY   A HA3  1 
ATOM   1949 N N    . THR   A 1 139 ? 11.81024  10.72710  19.53045  1.000 35.94391  ? 501 THR   A N    1 
ATOM   1950 C CA   . THR   A 1 139 ? 12.80528  11.75716  19.78371  1.000 36.42555  ? 501 THR   A CA   1 
ATOM   1951 C C    . THR   A 1 139 ? 13.75721  11.35249  20.90084  1.000 34.44774  ? 501 THR   A C    1 
ATOM   1952 O O    . THR   A 1 139 ? 13.32017  10.92622  21.97434  1.000 32.07180  ? 501 THR   A O    1 
ATOM   1953 C CB   . THR   A 1 139 ? 12.16062  13.10167  20.16370  1.000 33.34376  ? 501 THR   A CB   1 
ATOM   1954 O OG1  . THR   A 1 139 ? 13.21598  13.98783  20.56639  1.000 36.76670  ? 501 THR   A OG1  1 
ATOM   1955 C CG2  . THR   A 1 139 ? 11.09130  12.97258  21.33154  1.000 29.63539  ? 501 THR   A CG2  1 
ATOM   1956 H H    . THR   A 1 139 ? 11.47894  10.37498  20.24168  1.000 43.14474  ? 501 THR   A H    1 
ATOM   1957 H HA   . THR   A 1 139 ? 13.31855  11.85437  18.96639  1.000 43.72271  ? 501 THR   A HA   1 
ATOM   1958 H HB   . THR   A 1 139 ? 11.67359  13.45151  19.40127  1.000 40.02456  ? 501 THR   A HB   1 
ATOM   1959 H HG1  . THR   A 1 139 ? 12.89684  14.73241  20.78856  1.000 44.13210  ? 501 THR   A HG1  1 
ATOM   1960 H HG21 . THR   A 1 139 ? 10.69572  13.83875  21.51639  1.000 35.57452  ? 501 THR   A HG21 1 
ATOM   1961 H HG22 . THR   A 1 139 ? 10.38973  12.35497  21.07220  1.000 35.57452  ? 501 THR   A HG22 1 
ATOM   1962 H HG23 . THR   A 1 139 ? 11.51856  12.64315  22.13766  1.000 35.57452  ? 501 THR   A HG23 1 
ATOM   1963 N N    . LEU   A 1 140 ? 15.05136  11.54410  20.65787  1.000 36.57153  ? 502 LEU   A N    1 
ATOM   1964 C CA   . LEU   A 1 140 ? 16.04397  11.34516  21.70149  1.000 33.25127  ? 502 LEU   A CA   1 
ATOM   1965 C C    . LEU   A 1 140 ? 16.14825  12.53182  22.65541  1.000 28.43224  ? 502 LEU   A C    1 
ATOM   1966 O O    . LEU   A 1 140 ? 16.56242  12.33940  23.79652  1.000 28.50682  ? 502 LEU   A O    1 
ATOM   1967 C CB   . LEU   A 1 140 ? 17.41874  11.08774  21.10312  1.000 36.09842  ? 502 LEU   A CB   1 
ATOM   1968 C CG   . LEU   A 1 140 ? 17.68449  9.79705   20.33576  1.000 38.23912  ? 502 LEU   A CG   1 
ATOM   1969 C CD1  . LEU   A 1 140 ? 19.14600  9.79841   19.86046  1.000 42.63300  ? 502 LEU   A CD1  1 
ATOM   1970 C CD2  . LEU   A 1 140 ? 17.40773  8.53342   21.13879  1.000 35.30791  ? 502 LEU   A CD2  1 
ATOM   1971 H H    . LEU   A 1 140 ? 15.37608  11.78820  19.89986  1.000 43.89789  ? 502 LEU   A H    1 
ATOM   1972 H HA   . LEU   A 1 140 ? 15.78131  10.56012  22.20708  1.000 39.91358  ? 502 LEU   A HA   1 
ATOM   1973 H HB2  . LEU   A 1 140 ? 17.60286  11.81228  20.48503  1.000 43.33016  ? 502 LEU   A HB2  1 
ATOM   1974 H HB3  . LEU   A 1 140 ? 18.05710  11.10423  21.83327  1.000 43.33016  ? 502 LEU   A HB3  1 
ATOM   1975 H HG   . LEU   A 1 140 ? 17.07126  9.77020   19.58468  1.000 45.89900  ? 502 LEU   A HG   1 
ATOM   1976 H HD11 . LEU   A 1 140 ? 19.31423  8.98822   19.35431  1.000 51.17165  ? 502 LEU   A HD11 1 
ATOM   1977 H HD12 . LEU   A 1 140 ? 19.29499  10.57572  19.29967  1.000 51.17165  ? 502 LEU   A HD12 1 
ATOM   1978 H HD13 . LEU   A 1 140 ? 19.72975  9.83212   20.63442  1.000 51.17165  ? 502 LEU   A HD13 1 
ATOM   1979 H HD21 . LEU   A 1 140 ? 17.64059  7.76030   20.60123  1.000 42.38154  ? 502 LEU   A HD21 1 
ATOM   1980 H HD22 . LEU   A 1 140 ? 17.94470  8.54857   21.94646  1.000 42.38154  ? 502 LEU   A HD22 1 
ATOM   1981 H HD23 . LEU   A 1 140 ? 16.46571  8.50510   21.36834  1.000 42.38154  ? 502 LEU   A HD23 1 
ATOM   1982 N N    . LYS   A 1 141 ? 15.77475  13.73874  22.22752  1.000 27.43636  ? 503 LYS   A N    1 
ATOM   1983 C CA   . LYS   A 1 141 ? 15.96594  14.95014  23.02405  1.000 30.62615  ? 503 LYS   A CA   1 
ATOM   1984 C C    . LYS   A 1 141 ? 14.66932  15.27939  23.74722  1.000 29.32767  ? 503 LYS   A C    1 
ATOM   1985 O O    . LYS   A 1 141 ? 13.64108  15.52154  23.10698  1.000 32.91670  ? 503 LYS   A O    1 
ATOM   1986 C CB   . LYS   A 1 141 ? 16.38466  16.14782  22.17322  1.000 32.67750  ? 503 LYS   A CB   1 
ATOM   1987 C CG   . LYS   A 1 141 ? 17.68550  16.01517  21.41918  1.000 45.20558  ? 503 LYS   A CG   1 
ATOM   1988 C CD   . LYS   A 1 141 ? 17.93438  17.24495  20.55179  1.000 43.12636  ? 503 LYS   A CD   1 
ATOM   1989 C CE   . LYS   A 1 141 ? 19.37135  17.34664  20.09160  1.000 69.23287  ? 503 LYS   A CE   1 
ATOM   1990 N NZ   . LYS   A 1 141 ? 19.93302  16.05459  19.61945  1.000 68.83645  ? 503 LYS   A NZ   1 
ATOM   1991 H H    . LYS   A 1 141 ? 15.40212  13.88281  21.46595  1.000 32.93568  ? 503 LYS   A H    1 
ATOM   1992 H HA   . LYS   A 1 141 ? 16.66950  14.77466  23.66834  1.000 36.76344  ? 503 LYS   A HA   1 
ATOM   1993 H HB2  . LYS   A 1 141 ? 15.68971  16.30795  21.51572  1.000 39.22506  ? 503 LYS   A HB2  1 
ATOM   1994 H HB3  . LYS   A 1 141 ? 16.47181  16.91693  22.75784  1.000 39.22506  ? 503 LYS   A HB3  1 
ATOM   1995 H HG2  . LYS   A 1 141 ? 18.41810  15.92902  22.04908  1.000 54.25875  ? 503 LYS   A HG2  1 
ATOM   1996 H HG3  . LYS   A 1 141 ? 17.64888  15.23484  20.84417  1.000 54.25875  ? 503 LYS   A HG3  1 
ATOM   1997 H HD2  . LYS   A 1 141 ? 17.36919  17.19819  19.76485  1.000 51.76368  ? 503 LYS   A HD2  1 
ATOM   1998 H HD3  . LYS   A 1 141 ? 17.72536  18.04206  21.06348  1.000 51.76368  ? 503 LYS   A HD3  1 
ATOM   1999 H HE2  . LYS   A 1 141 ? 19.42168  17.97833  19.35721  1.000 83.09150  ? 503 LYS   A HE2  1 
ATOM   2000 H HE3  . LYS   A 1 141 ? 19.91693  17.65466  20.83212  1.000 83.09150  ? 503 LYS   A HE3  1 
ATOM   2001 H HZ1  . LYS   A 1 141 ? 20.75551  16.17787  19.30257  1.000 82.61579  ? 503 LYS   A HZ1  1 
ATOM   2002 H HZ2  . LYS   A 1 141 ? 19.96693  15.47331  20.29255  1.000 82.61579  ? 503 LYS   A HZ2  1 
ATOM   2003 H HZ3  . LYS   A 1 141 ? 19.42182  15.71851  18.97306  1.000 82.61579  ? 503 LYS   A HZ3  1 
ATOM   2004 N N    . ARG   A 1 142 ? 14.74210  15.31040  25.07422  1.000 29.01933  ? 504 ARG   A N    1 
ATOM   2005 C CA   . ARG   A 1 142 ? 13.57947  15.61039  25.89982  1.000 29.35808  ? 504 ARG   A CA   1 
ATOM   2006 C C    . ARG   A 1 142 ? 12.90452  16.90683  25.47805  1.000 31.69840  ? 504 ARG   A C    1 
ATOM   2007 O O    . ARG   A 1 142 ? 11.67730  16.97966  25.42693  1.000 27.71935  ? 504 ARG   A O    1 
ATOM   2008 C CB   . ARG   A 1 142 ? 14.01574  15.69300  27.36032  1.000 27.96316  ? 504 ARG   A CB   1 
ATOM   2009 C CG   . ARG   A 1 142 ? 12.91875  16.05657  28.30949  1.000 27.40197  ? 504 ARG   A CG   1 
ATOM   2010 C CD   . ARG   A 1 142 ? 13.31200  15.83545  29.75095  1.000 35.49738  ? 504 ARG   A CD   1 
ATOM   2011 N NE   . ARG   A 1 142 ? 14.62489  16.38669  30.05350  1.000 30.71612  ? 504 ARG   A NE   1 
ATOM   2012 C CZ   . ARG   A 1 142 ? 14.88400  17.63806  30.41118  1.000 28.49936  ? 504 ARG   A CZ   1 
ATOM   2013 N NH1  . ARG   A 1 142 ? 13.92669  18.54155  30.54616  1.000 33.03081  ? 504 ARG   A NH1  1 
ATOM   2014 N NH2  . ARG   A 1 142 ? 16.14316  17.99851  30.63137  1.000 25.74427  ? 504 ARG   A NH2  1 
ATOM   2015 H H    . ARG   A 1 142 ? 15.45876  15.16015  25.52524  1.000 34.83525  ? 504 ARG   A H    1 
ATOM   2016 H HA   . ARG   A 1 142 ? 12.92875  14.89777  25.80161  1.000 35.24175  ? 504 ARG   A HA   1 
ATOM   2017 H HB2  . ARG   A 1 142 ? 14.36280  14.82812  27.62945  1.000 33.56785  ? 504 ARG   A HB2  1 
ATOM   2018 H HB3  . ARG   A 1 142 ? 14.70834  16.36754  27.43915  1.000 33.56785  ? 504 ARG   A HB3  1 
ATOM   2019 H HG2  . ARG   A 1 142 ? 12.69873  16.99462  28.19744  1.000 32.89441  ? 504 ARG   A HG2  1 
ATOM   2020 H HG3  . ARG   A 1 142 ? 12.14071  15.50859  28.12172  1.000 32.89441  ? 504 ARG   A HG3  1 
ATOM   2021 H HD2  . ARG   A 1 142 ? 12.66274  16.26720  30.32798  1.000 42.60891  ? 504 ARG   A HD2  1 
ATOM   2022 H HD3  . ARG   A 1 142 ? 13.33521  14.88281  29.93216  1.000 42.60891  ? 504 ARG   A HD3  1 
ATOM   2023 H HE   . ARG   A 1 142 ? 15.29534  15.85128  29.99496  1.000 36.87139  ? 504 ARG   A HE   1 
ATOM   2024 H HH11 . ARG   A 1 142 ? 13.10725  18.32480  30.40077  1.000 39.64902  ? 504 ARG   A HH11 1 
ATOM   2025 H HH12 . ARG   A 1 142 ? 14.12395  19.34551  30.77927  1.000 39.64902  ? 504 ARG   A HH12 1 
ATOM   2026 H HH21 . ARG   A 1 142 ? 16.77685  17.42407  30.54161  1.000 30.90518  ? 504 ARG   A HH21 1 
ATOM   2027 H HH22 . ARG   A 1 142 ? 16.32482  18.80636  30.86370  1.000 30.90518  ? 504 ARG   A HH22 1 
ATOM   2028 N N    . LEU   A 1 143 ? 13.68885  17.92726  25.11983  1.000 29.36173  ? 505 LEU   A N    1 
ATOM   2029 C CA   . LEU   A 1 143 ? 13.17455  19.26919  24.88925  1.000 30.28795  ? 505 LEU   A CA   1 
ATOM   2030 C C    . LEU   A 1 143 ? 13.05278  19.61852  23.40877  1.000 31.72728  ? 505 LEU   A C    1 
ATOM   2031 O O    . LEU   A 1 143 ? 12.81896  20.78414  23.07743  1.000 29.62394  ? 505 LEU   A O    1 
ATOM   2032 C CB   . LEU   A 1 143 ? 14.08669  20.28959  25.58630  1.000 29.72789  ? 505 LEU   A CB   1 
ATOM   2033 C CG   . LEU   A 1 143 ? 14.25707  20.13905  27.10310  1.000 26.94237  ? 505 LEU   A CG   1 
ATOM   2034 C CD1  . LEU   A 1 143 ? 15.44077  20.96937  27.63464  1.000 39.51271  ? 505 LEU   A CD1  1 
ATOM   2035 C CD2  . LEU   A 1 143 ? 12.99923  20.55161  27.83477  1.000 35.61212  ? 505 LEU   A CD2  1 
ATOM   2036 H H    . LEU   A 1 143 ? 14.53827  17.86028  25.00316  1.000 35.24613  ? 505 LEU   A H    1 
ATOM   2037 H HA   . LEU   A 1 143 ? 12.28593  19.32810  25.27367  1.000 36.35759  ? 505 LEU   A HA   1 
ATOM   2038 H HB2  . LEU   A 1 143 ? 14.97049  20.21931  25.19277  1.000 35.68552  ? 505 LEU   A HB2  1 
ATOM   2039 H HB3  . LEU   A 1 143 ? 13.72236  21.17448  25.42777  1.000 35.68552  ? 505 LEU   A HB3  1 
ATOM   2040 H HG   . LEU   A 1 143 ? 14.43751  19.20219  27.27817  1.000 32.34290  ? 505 LEU   A HG   1 
ATOM   2041 H HD11 . LEU   A 1 143 ? 15.56734  20.77225  28.57593  1.000 47.42730  ? 505 LEU   A HD11 1 
ATOM   2042 H HD12 . LEU   A 1 143 ? 16.23976  20.73469  27.13719  1.000 47.42730  ? 505 LEU   A HD12 1 
ATOM   2043 H HD13 . LEU   A 1 143 ? 15.24319  21.91180  27.51770  1.000 47.42730  ? 505 LEU   A HD13 1 
ATOM   2044 H HD21 . LEU   A 1 143 ? 13.15520  20.49046  28.79020  1.000 42.74660  ? 505 LEU   A HD21 1 
ATOM   2045 H HD22 . LEU   A 1 143 ? 12.77863  21.46484  27.59341  1.000 42.74660  ? 505 LEU   A HD22 1 
ATOM   2046 H HD23 . LEU   A 1 143 ? 12.27600  19.95796  27.57901  1.000 42.74660  ? 505 LEU   A HD23 1 
ATOM   2047 N N    . SER   A 1 144 ? 13.22918  18.65476  22.51494  1.000 29.78121  ? 506 SER   A N    1 
ATOM   2048 C CA   . SER   A 1 144 ? 13.20092  18.98804  21.10409  1.000 36.49536  ? 506 SER   A CA   1 
ATOM   2049 C C    . SER   A 1 144 ? 11.78349  19.40060  20.70680  1.000 30.52433  ? 506 SER   A C    1 
ATOM   2050 O O    . SER   A 1 144 ? 10.81355  18.85805  21.24200  1.000 33.75053  ? 506 SER   A O    1 
ATOM   2051 C CB   . SER   A 1 144 ? 13.65341  17.81118  20.26357  1.000 34.72251  ? 506 SER   A CB   1 
ATOM   2052 O OG   . SER   A 1 144 ? 13.14163  17.95983  18.96236  1.000 36.42381  ? 506 SER   A OG   1 
ATOM   2053 H H    . SER   A 1 144 ? 13.36301  17.82475  22.69597  1.000 35.74951  ? 506 SER   A H    1 
ATOM   2054 H HA   . SER   A 1 144 ? 13.80513  19.72641  20.92906  1.000 43.80648  ? 506 SER   A HA   1 
ATOM   2055 H HB2  . SER   A 1 144 ? 14.62262  17.79088  20.22997  1.000 41.67907  ? 506 SER   A HB2  1 
ATOM   2056 H HB3  . SER   A 1 144 ? 13.31759  16.98802  20.65154  1.000 41.67907  ? 506 SER   A HB3  1 
ATOM   2057 H HG   . SER   A 1 144 ? 12.44356  17.50102  18.87405  1.000 43.72063  ? 506 SER   A HG   1 
ATOM   2058 N N    . PRO   A 1 145 ? 11.62231  20.39278  19.81576  1.000 33.99457  ? 507 PRO   A N    1 
ATOM   2059 C CA   . PRO   A 1 145 ? 10.26703  20.69979  19.31785  1.000 38.75939  ? 507 PRO   A CA   1 
ATOM   2060 C C    . PRO   A 1 145 ? 9.78997   19.76168  18.22108  1.000 33.50260  ? 507 PRO   A C    1 
ATOM   2061 O O    . PRO   A 1 145 ? 8.61576   19.82440  17.84578  1.000 42.42011  ? 507 PRO   A O    1 
ATOM   2062 C CB   . PRO   A 1 145 ? 10.41299  22.12779  18.79484  1.000 39.96767  ? 507 PRO   A CB   1 
ATOM   2063 C CG   . PRO   A 1 145 ? 11.85907  22.18076  18.31498  1.000 32.69364  ? 507 PRO   A CG   1 
ATOM   2064 C CD   . PRO   A 1 145 ? 12.64147  21.20408  19.11855  1.000 35.47932  ? 507 PRO   A CD   1 
ATOM   2065 H HA   . PRO   A 1 145 ? 9.62572   20.69226  20.04556  1.000 46.52333  ? 507 PRO   A HA   1 
ATOM   2066 H HB2  . PRO   A 1 145 ? 9.79295   22.28438  18.06550  1.000 47.97326  ? 507 PRO   A HB2  1 
ATOM   2067 H HB3  . PRO   A 1 145 ? 10.25404  22.76563  19.50814  1.000 47.97326  ? 507 PRO   A HB3  1 
ATOM   2068 H HG2  . PRO   A 1 145 ? 11.89198  21.94538  17.37455  1.000 39.24442  ? 507 PRO   A HG2  1 
ATOM   2069 H HG3  . PRO   A 1 145 ? 12.20570  23.07734  18.44490  1.000 39.24442  ? 507 PRO   A HG3  1 
ATOM   2070 H HD2  . PRO   A 1 145 ? 13.18396  20.64515  18.54044  1.000 42.58724  ? 507 PRO   A HD2  1 
ATOM   2071 H HD3  . PRO   A 1 145 ? 13.20565  21.66505  19.75894  1.000 42.58724  ? 507 PRO   A HD3  1 
ATOM   2072 N N    . HIS   A 1 146 ? 10.65574  18.90675  17.68931  1.000 37.93178  ? 508 HIS   A N    1 
ATOM   2073 C CA   . HIS   A 1 146 ? 10.29557  17.91913  16.67844  1.000 35.44202  ? 508 HIS   A CA   1 
ATOM   2074 C C    . HIS   A 1 146 ? 10.08245  16.56974  17.34766  1.000 36.36845  ? 508 HIS   A C    1 
ATOM   2075 O O    . HIS   A 1 146 ? 11.03343  15.97753  17.86131  1.000 33.58150  ? 508 HIS   A O    1 
ATOM   2076 C CB   . HIS   A 1 146 ? 11.39655  17.78052  15.62964  1.000 39.59047  ? 508 HIS   A CB   1 
ATOM   2077 C CG   . HIS   A 1 146 ? 11.91296  19.09131  15.13200  1.000 48.04844  ? 508 HIS   A CG   1 
ATOM   2078 N ND1  . HIS   A 1 146 ? 11.07682  20.13998  14.80784  1.000 45.55751  ? 508 HIS   A ND1  1 
ATOM   2079 C CD2  . HIS   A 1 146 ? 13.17839  19.53808  14.93959  1.000 42.37151  ? 508 HIS   A CD2  1 
ATOM   2080 C CE1  . HIS   A 1 146 ? 11.81074  21.17507  14.43183  1.000 45.83446  ? 508 HIS   A CE1  1 
ATOM   2081 N NE2  . HIS   A 1 146 ? 13.08719  20.83100  14.49725  1.000 43.12786  ? 508 HIS   A NE2  1 
ATOM   2082 H H    . HIS   A 1 146 ? 11.48761  18.87814  17.90559  1.000 45.53019  ? 508 HIS   A H    1 
ATOM   2083 H HA   . HIS   A 1 146 ? 9.47339   18.20287  16.24900  1.000 42.54248  ? 508 HIS   A HA   1 
ATOM   2084 H HB2  . HIS   A 1 146 ? 12.14115  17.29640  16.01964  1.000 47.52062  ? 508 HIS   A HB2  1 
ATOM   2085 H HB3  . HIS   A 1 146 ? 11.04474  17.29163  14.86930  1.000 47.52062  ? 508 HIS   A HB3  1 
ATOM   2086 H HD2  . HIS   A 1 146 ? 13.96148  19.05686  15.08138  1.000 50.85787  ? 508 HIS   A HD2  1 
ATOM   2087 H HE1  . HIS   A 1 146 ? 11.48456  22.00453  14.16633  1.000 55.01341  ? 508 HIS   A HE1  1 
ATOM   2088 H HE2  . HIS   A 1 146 ? 13.75198  21.33758  14.29468  1.000 51.76548  ? 508 HIS   A HE2  1 
ATOM   2089 N N    . TYR   A 1 147 ? 8.86763   16.05143  17.26854  1.000 35.42155  ? 509 TYR   A N    1 
ATOM   2090 C CA   . TYR   A 1 147 ? 8.52809   14.78949  17.90870  1.000 28.26900  ? 509 TYR   A CA   1 
ATOM   2091 C C    . TYR   A 1 147 ? 7.16609   14.39597  17.37146  1.000 31.75948  ? 509 TYR   A C    1 
ATOM   2092 O O    . TYR   A 1 147 ? 6.46861   15.19868  16.75019  1.000 31.64274  ? 509 TYR   A O    1 
ATOM   2093 C CB   . TYR   A 1 147 ? 8.50475   14.90904  19.43208  1.000 28.56462  ? 509 TYR   A CB   1 
ATOM   2094 C CG   . TYR   A 1 147 ? 7.60183   16.00781  19.97658  1.000 30.15477  ? 509 TYR   A CG   1 
ATOM   2095 C CD1  . TYR   A 1 147 ? 6.25019   15.79935  20.15228  1.000 30.76611  ? 509 TYR   A CD1  1 
ATOM   2096 C CD2  . TYR   A 1 147 ? 8.11726   17.24654  20.34017  1.000 30.17047  ? 509 TYR   A CD2  1 
ATOM   2097 C CE1  . TYR   A 1 147 ? 5.42674   16.79554  20.63558  1.000 34.04718  ? 509 TYR   A CE1  1 
ATOM   2098 C CE2  . TYR   A 1 147 ? 7.32028   18.21372  20.84010  1.000 34.45002  ? 509 TYR   A CE2  1 
ATOM   2099 C CZ   . TYR   A 1 147 ? 5.96625   17.99740  20.98221  1.000 34.33894  ? 509 TYR   A CZ   1 
ATOM   2100 O OH   . TYR   A 1 147 ? 5.16974   19.00477  21.49020  1.000 44.56412  ? 509 TYR   A OH   1 
ATOM   2101 H H    . TYR   A 1 147 ? 8.21355   16.41513  16.84487  1.000 42.51791  ? 509 TYR   A H    1 
ATOM   2102 H HA   . TYR   A 1 147 ? 9.18014   14.10832  17.68123  1.000 33.93486  ? 509 TYR   A HA   1 
ATOM   2103 H HB2  . TYR   A 1 147 ? 8.19431   14.06759  19.80154  1.000 34.28960  ? 509 TYR   A HB2  1 
ATOM   2104 H HB3  . TYR   A 1 147 ? 9.40595   15.09399  19.73955  1.000 34.28960  ? 509 TYR   A HB3  1 
ATOM   2105 H HD1  . TYR   A 1 147 ? 5.88600   14.97020  19.94067  1.000 36.93139  ? 509 TYR   A HD1  1 
ATOM   2106 H HD2  . TYR   A 1 147 ? 9.02671   17.41141  20.23710  1.000 36.21662  ? 509 TYR   A HD2  1 
ATOM   2107 H HE1  . TYR   A 1 147 ? 4.51277   16.64795  20.72377  1.000 40.86867  ? 509 TYR   A HE1  1 
ATOM   2108 H HE2  . TYR   A 1 147 ? 7.68658   19.03111  21.09028  1.000 41.35208  ? 509 TYR   A HE2  1 
ATOM   2109 H HH   . TYR   A 1 147 ? 4.36771   18.75569  21.50764  1.000 53.48900  ? 509 TYR   A HH   1 
ATOM   2110 N N    . THR   A 1 148 ? 6.80363   13.15436  17.61995  1.000 26.58653  ? 510 THR   A N    1 
ATOM   2111 C CA   . THR   A 1 148 ? 5.47753   12.64665  17.34326  1.000 26.75270  ? 510 THR   A CA   1 
ATOM   2112 C C    . THR   A 1 148 ? 4.61028   12.91511  18.55503  1.000 28.73485  ? 510 THR   A C    1 
ATOM   2113 O O    . THR   A 1 148 ? 4.90658   12.45319  19.65738  1.000 32.24938  ? 510 THR   A O    1 
ATOM   2114 C CB   . THR   A 1 148 ? 5.57320   11.16841  17.01174  1.000 31.53753  ? 510 THR   A CB   1 
ATOM   2115 O OG1  . THR   A 1 148 ? 6.17348   11.06978  15.72384  1.000 30.26855  ? 510 THR   A OG1  1 
ATOM   2116 C CG2  . THR   A 1 148 ? 4.18854   10.49580  17.02916  1.000 28.57566  ? 510 THR   A CG2  1 
ATOM   2117 H H    . THR   A 1 148 ? 7.32754   12.56415  17.96167  1.000 31.91589  ? 510 THR   A H    1 
ATOM   2118 H HA   . THR   A 1 148 ? 5.06733   13.09368  16.58642  1.000 32.11530  ? 510 THR   A HA   1 
ATOM   2119 H HB   . THR   A 1 148 ? 6.10416   10.69456  17.67087  1.000 37.85709  ? 510 THR   A HB   1 
ATOM   2120 H HG1  . THR   A 1 148 ? 6.25735   10.26260  15.50701  1.000 36.33431  ? 510 THR   A HG1  1 
ATOM   2121 H HG21 . THR   A 1 148 ? 4.22812   9.64307   16.56853  1.000 34.30285  ? 510 THR   A HG21 1 
ATOM   2122 H HG22 . THR   A 1 148 ? 3.90381   10.34633  17.94430  1.000 34.30285  ? 510 THR   A HG22 1 
ATOM   2123 H HG23 . THR   A 1 148 ? 3.53852   11.06316  16.58591  1.000 34.30285  ? 510 THR   A HG23 1 
ATOM   2124 N N    . GLN   A 1 149 ? 3.53851   13.65214  18.34168  1.000 26.10425  ? 511 GLN   A N    1 
ATOM   2125 C CA   . GLN   A 1 149 ? 2.61255   14.01262  19.39678  1.000 29.60562  ? 511 GLN   A CA   1 
ATOM   2126 C C    . GLN   A 1 149 ? 1.53421   12.95335  19.53648  1.000 33.84445  ? 511 GLN   A C    1 
ATOM   2127 O O    . GLN   A 1 149 ? 1.01147   12.43976  18.55443  1.000 28.99635  ? 511 GLN   A O    1 
ATOM   2128 C CB   . GLN   A 1 149 ? 1.96549   15.37102  19.08294  1.000 33.85257  ? 511 GLN   A CB   1 
ATOM   2129 C CG   . GLN   A 1 149 ? 1.01321   15.87983  20.14961  1.000 34.37003  ? 511 GLN   A CG   1 
ATOM   2130 C CD   . GLN   A 1 149 ? 1.74033   16.44168  21.35609  1.000 37.11356  ? 511 GLN   A CD   1 
ATOM   2131 O OE1  . GLN   A 1 149 ? 2.26251   17.52926  21.30826  1.000 38.68590  ? 511 GLN   A OE1  1 
ATOM   2132 N NE2  . GLN   A 1 149 ? 1.75845   15.68746  22.44487  1.000 35.13945  ? 511 GLN   A NE2  1 
ATOM   2133 H H    . GLN   A 1 149 ? 3.31812   13.96555  17.57174  1.000 31.33715  ? 511 GLN   A H    1 
ATOM   2134 H HA   . GLN   A 1 149 ? 3.08662   14.07655  20.24062  1.000 35.53880  ? 511 GLN   A HA   1 
ATOM   2135 H HB2  . GLN   A 1 149 ? 2.66875   16.03111  18.97990  1.000 40.63514  ? 511 GLN   A HB2  1 
ATOM   2136 H HB3  . GLN   A 1 149 ? 1.46311   15.28984  18.25715  1.000 40.63514  ? 511 GLN   A HB3  1 
ATOM   2137 H HG2  . GLN   A 1 149 ? 0.46373   16.58532  19.77377  1.000 41.25609  ? 511 GLN   A HG2  1 
ATOM   2138 H HG3  . GLN   A 1 149 ? 0.45285   15.14727  20.45002  1.000 41.25609  ? 511 GLN   A HG3  1 
ATOM   2139 H HE21 . GLN   A 1 149 ? 1.36971   14.92034  22.44308  1.000 42.17939  ? 511 GLN   A HE21 1 
ATOM   2140 H HE22 . GLN   A 1 149 ? 2.15896   15.96491  23.15354  1.000 42.17939  ? 511 GLN   A HE22 1 
ATOM   2141 N N    . ALA   A 1 150 ? 1.19330   12.65956  20.78003  1.000 31.21873  ? 512 ALA   A N    1 
ATOM   2142 C CA   . ALA   A 1 150 ? 0.05271   11.84197  21.10665  1.000 34.19302  ? 512 ALA   A CA   1 
ATOM   2143 C C    . ALA   A 1 150 ? -0.59104  12.43422  22.34425  1.000 37.42262  ? 512 ALA   A C    1 
ATOM   2144 O O    . ALA   A 1 150 ? 0.03464   13.18011  23.10693  1.000 32.39993  ? 512 ALA   A O    1 
ATOM   2145 C CB   . ALA   A 1 150 ? 0.45171   10.38984  21.35247  1.000 34.61950  ? 512 ALA   A CB   1 
ATOM   2146 H H    . ALA   A 1 150 ? 1.62487   12.93377  21.47152  1.000 37.47453  ? 512 ALA   A H    1 
ATOM   2147 H HA   . ALA   A 1 150 ? -0.58969  11.84636  20.37988  1.000 41.04368  ? 512 ALA   A HA   1 
ATOM   2148 H HB1  . ALA   A 1 150 ? -0.34608  9.87019   21.53790  1.000 41.55545  ? 512 ALA   A HB1  1 
ATOM   2149 H HB2  . ALA   A 1 150 ? 0.89415   10.04557  20.56088  1.000 41.55545  ? 512 ALA   A HB2  1 
ATOM   2150 H HB3  . ALA   A 1 150 ? 1.05480   10.35216  22.11127  1.000 41.55545  ? 512 ALA   A HB3  1 
ATOM   2151 N N    . TRP   A 1 151 ? -1.85663  12.10941  22.52703  1.000 30.04674  ? 513 TRP   A N    1 
ATOM   2152 C CA   . TRP   A 1 151 ? -2.61440  12.54974  23.67762  1.000 37.22131  ? 513 TRP   A CA   1 
ATOM   2153 C C    . TRP   A 1 151 ? -3.33431  11.34653  24.25065  1.000 35.02798  ? 513 TRP   A C    1 
ATOM   2154 O O    . TRP   A 1 151 ? -3.77691  10.46804  23.50398  1.000 35.39843  ? 513 TRP   A O    1 
ATOM   2155 C CB   . TRP   A 1 151 ? -3.60413  13.64976  23.28196  1.000 38.17706  ? 513 TRP   A CB   1 
ATOM   2156 C CG   . TRP   A 1 151 ? -2.91621  14.83728  22.74633  1.000 38.95247  ? 513 TRP   A CG   1 
ATOM   2157 C CD1  . TRP   A 1 151 ? -2.72714  15.13592  21.44754  1.000 35.14915  ? 513 TRP   A CD1  1 
ATOM   2158 C CD2  . TRP   A 1 151 ? -2.30011  15.89201  23.50465  1.000 38.95304  ? 513 TRP   A CD2  1 
ATOM   2159 N NE1  . TRP   A 1 151 ? -2.02615  16.30982  21.32982  1.000 44.81837  ? 513 TRP   A NE1  1 
ATOM   2160 C CE2  . TRP   A 1 151 ? -1.74892  16.79244  22.58240  1.000 38.91179  ? 513 TRP   A CE2  1 
ATOM   2161 C CE3  . TRP   A 1 151 ? -2.15760  16.15023  24.87424  1.000 41.45074  ? 513 TRP   A CE3  1 
ATOM   2162 C CZ2  . TRP   A 1 151 ? -1.08083  17.94600  22.97623  1.000 41.65925  ? 513 TRP   A CZ2  1 
ATOM   2163 C CZ3  . TRP   A 1 151 ? -1.49016  17.27935  25.26714  1.000 45.34770  ? 513 TRP   A CZ3  1 
ATOM   2164 C CH2  . TRP   A 1 151 ? -0.96261  18.17651  24.32187  1.000 47.08366  ? 513 TRP   A CH2  1 
ATOM   2165 H H    . TRP   A 1 151 ? -2.30953  11.62139  21.98267  1.000 36.06815  ? 513 TRP   A H    1 
ATOM   2166 H HA   . TRP   A 1 151 ? -2.03596  12.91409  24.36578  1.000 44.67763  ? 513 TRP   A HA   1 
ATOM   2167 H HB2  . TRP   A 1 151 ? -4.20250  13.31036  22.59810  1.000 45.82453  ? 513 TRP   A HB2  1 
ATOM   2168 H HB3  . TRP   A 1 151 ? -4.11199  13.91882  24.06336  1.000 45.82453  ? 513 TRP   A HB3  1 
ATOM   2169 H HD1  . TRP   A 1 151 ? -3.02790  14.62141  20.73359  1.000 42.19103  ? 513 TRP   A HD1  1 
ATOM   2170 H HE1  . TRP   A 1 151 ? -1.79758  16.68266  20.58931  1.000 53.79409  ? 513 TRP   A HE1  1 
ATOM   2171 H HE3  . TRP   A 1 151 ? -2.51008  15.56510  25.50533  1.000 49.75294  ? 513 TRP   A HE3  1 
ATOM   2172 H HZ2  . TRP   A 1 151 ? -0.72816  18.53774  22.35143  1.000 50.00315  ? 513 TRP   A HZ2  1 
ATOM   2173 H HZ3  . TRP   A 1 151 ? -1.38405  17.45571  26.17408  1.000 54.42929  ? 513 TRP   A HZ3  1 
ATOM   2174 H HH2  . TRP   A 1 151 ? -0.52435  18.94225  24.61593  1.000 56.51245  ? 513 TRP   A HH2  1 
ATOM   2175 N N    . SER   A 1 152 ? -3.42806  11.30756  25.57440  1.000 32.09462  ? 514 SER   A N    1 
ATOM   2176 C CA   . SER   A 1 152 ? -4.18719  10.26835  26.23636  1.000 31.94523  ? 514 SER   A CA   1 
ATOM   2177 C C    . SER   A 1 152 ? -5.66916  10.45613  25.93767  1.000 38.30086  ? 514 SER   A C    1 
ATOM   2178 O O    . SER   A 1 152 ? -6.21496  11.55444  26.07735  1.000 31.51797  ? 514 SER   A O    1 
ATOM   2179 C CB   . SER   A 1 152 ? -3.94171  10.29998  27.73289  1.000 34.25562  ? 514 SER   A CB   1 
ATOM   2180 O OG   . SER   A 1 152 ? -4.23369  11.56124  28.29655  1.000 35.31991  ? 514 SER   A OG   1 
ATOM   2181 H H    . SER   A 1 152 ? -3.06001  11.87286  26.10785  1.000 38.52560  ? 514 SER   A H    1 
ATOM   2182 H HA   . SER   A 1 152 ? -3.90680  9.39894   25.91013  1.000 38.34633  ? 514 SER   A HA   1 
ATOM   2183 H HB2  . SER   A 1 152 ? -4.50723  9.63381   28.15396  1.000 41.11880  ? 514 SER   A HB2  1 
ATOM   2184 H HB3  . SER   A 1 152 ? -3.00814  10.09509  27.89832  1.000 41.11880  ? 514 SER   A HB3  1 
ATOM   2185 H HG   . SER   A 1 152 ? -4.39259  11.47929  29.11730  1.000 42.39594  ? 514 SER   A HG   1 
ATOM   2186 N N    . GLU   A 1 153 ? -6.29553  9.38595   25.47162  1.000 33.74920  ? 515 GLU   A N    1 
ATOM   2187 C CA   . GLU   A 1 153 ? -7.74276  9.24028   25.43410  1.000 38.96392  ? 515 GLU   A CA   1 
ATOM   2188 C C    . GLU   A 1 153 ? -8.27299  8.71109   26.75853  1.000 41.53610  ? 515 GLU   A C    1 
ATOM   2189 O O    . GLU   A 1 153 ? -9.36302  9.10180   27.18645  1.000 40.24192  ? 515 GLU   A O    1 
ATOM   2190 C CB   . GLU   A 1 153 ? -8.11323  8.28915   24.29148  1.000 40.88521  ? 515 GLU   A CB   1 
ATOM   2191 C CG   . GLU   A 1 153 ? -9.54724  7.77672   24.25136  1.000 54.08264  ? 515 GLU   A CG   1 
ATOM   2192 C CD   . GLU   A 1 153 ? -9.84475  7.01360   22.96451  1.000 64.33765  ? 515 GLU   A CD   1 
ATOM   2193 O OE1  . GLU   A 1 153 ? -9.87040  7.63644   21.88187  1.000 83.38559  ? 515 GLU   A OE1  1 
ATOM   2194 O OE2  . GLU   A 1 153 ? -10.04804 5.78728   23.03558  1.000 69.35776  ? 515 GLU   A OE2  1 
ATOM   2195 H H    . GLU   A 1 153 ? -5.88675  8.69800   25.15659  1.000 40.51109  ? 515 GLU   A H    1 
ATOM   2196 H HA   . GLU   A 1 153 ? -8.17432  10.09111  25.25874  1.000 46.76876  ? 515 GLU   A HA   1 
ATOM   2197 H HB2  . GLU   A 1 153 ? -7.95642  8.75299   23.45412  1.000 49.07430  ? 515 GLU   A HB2  1 
ATOM   2198 H HB3  . GLU   A 1 153 ? -7.53765  7.51076   24.35240  1.000 49.07430  ? 515 GLU   A HB3  1 
ATOM   2199 H HG2  . GLU   A 1 153 ? -9.69302  7.17737   24.99998  1.000 64.91122  ? 515 GLU   A HG2  1 
ATOM   2200 H HG3  . GLU   A 1 153 ? -10.15672 8.52939   24.30541  1.000 64.91122  ? 515 GLU   A HG3  1 
ATOM   2201 N N    . ALA   A 1 154 ? -7.51204  7.84115   27.42314  1.000 32.50470  ? 516 ALA   A N    1 
ATOM   2202 C CA   . ALA   A 1 154 ? -7.94127  7.20500   28.65801  1.000 31.19780  ? 516 ALA   A CA   1 
ATOM   2203 C C    . ALA   A 1 154 ? -6.70852  6.72166   29.40254  1.000 29.84878  ? 516 ALA   A C    1 
ATOM   2204 O O    . ALA   A 1 154 ? -5.75563  6.25910   28.77645  1.000 27.42808  ? 516 ALA   A O    1 
ATOM   2205 C CB   . ALA   A 1 154 ? -8.88402  6.02886   28.38000  1.000 27.64985  ? 516 ALA   A CB   1 
ATOM   2206 H H    . ALA   A 1 154 ? -6.72616  7.60020   27.17027  1.000 39.01770  ? 516 ALA   A H    1 
ATOM   2207 H HA   . ALA   A 1 154 ? -8.40987  7.84818   29.21266  1.000 37.44942  ? 516 ALA   A HA   1 
ATOM   2208 H HB1  . ALA   A 1 154 ? -9.13319  5.61788   29.22255  1.000 33.19188  ? 516 ALA   A HB1  1 
ATOM   2209 H HB2  . ALA   A 1 154 ? -9.67524  6.35880   27.92613  1.000 33.19188  ? 516 ALA   A HB2  1 
ATOM   2210 H HB3  . ALA   A 1 154 ? -8.42632  5.38293   27.81947  1.000 33.19188  ? 516 ALA   A HB3  1 
ATOM   2211 N N    . VAL   A 1 155 ? -6.73833  6.82638   30.73041  1.000 29.51056  ? 517 VAL   A N    1 
ATOM   2212 C CA   . VAL   A 1 155 ? -5.64791  6.38833   31.59463  1.000 27.18459  ? 517 VAL   A CA   1 
ATOM   2213 C C    . VAL   A 1 155 ? -6.20796  5.38045   32.59158  1.000 30.96105  ? 517 VAL   A C    1 
ATOM   2214 O O    . VAL   A 1 155 ? -7.19418  5.66437   33.27553  1.000 27.40463  ? 517 VAL   A O    1 
ATOM   2215 C CB   . VAL   A 1 155 ? -4.98877  7.58472   32.32291  1.000 28.52198  ? 517 VAL   A CB   1 
ATOM   2216 C CG1  . VAL   A 1 155 ? -3.91325  7.12317   33.26331  1.000 32.63594  ? 517 VAL   A CG1  1 
ATOM   2217 C CG2  . VAL   A 1 155 ? -4.43221  8.58699   31.32230  1.000 32.51839  ? 517 VAL   A CG2  1 
ATOM   2218 H H    . VAL   A 1 155 ? -7.40159  7.15875   31.16540  1.000 35.42472  ? 517 VAL   A H    1 
ATOM   2219 H HA   . VAL   A 1 155 ? -4.96864  5.94395   31.06358  1.000 32.63356  ? 517 VAL   A HA   1 
ATOM   2220 H HB   . VAL   A 1 155 ? -5.67059  8.03021   32.84976  1.000 34.23843  ? 517 VAL   A HB   1 
ATOM   2221 H HG11 . VAL   A 1 155 ? -3.34283  7.87588   33.48454  1.000 39.17518  ? 517 VAL   A HG11 1 
ATOM   2222 H HG12 . VAL   A 1 155 ? -4.32633  6.77337   34.06824  1.000 39.17518  ? 517 VAL   A HG12 1 
ATOM   2223 H HG13 . VAL   A 1 155 ? -3.39192  6.42902   32.83057  1.000 39.17518  ? 517 VAL   A HG13 1 
ATOM   2224 H HG21 . VAL   A 1 155 ? -3.94560  9.27533   31.80219  1.000 39.03412  ? 517 VAL   A HG21 1 
ATOM   2225 H HG22 . VAL   A 1 155 ? -3.83653  8.12571   30.71133  1.000 39.03412  ? 517 VAL   A HG22 1 
ATOM   2226 H HG23 . VAL   A 1 155 ? -5.16798  8.98394   30.83039  1.000 39.03412  ? 517 VAL   A HG23 1 
ATOM   2227 N N    . PHE   A 1 156 ? -5.56642  4.21080   32.67684  1.000 23.97336  ? 518 PHE   A N    1 
ATOM   2228 C CA   . PHE   A 1 156 ? -5.96493  3.14686   33.58692  1.000 22.76993  ? 518 PHE   A CA   1 
ATOM   2229 C C    . PHE   A 1 156 ? -4.86664  2.99756   34.61589  1.000 26.80901  ? 518 PHE   A C    1 
ATOM   2230 O O    . PHE   A 1 156 ? -3.74936  2.60246   34.27115  1.000 27.34367  ? 518 PHE   A O    1 
ATOM   2231 C CB   . PHE   A 1 156 ? -6.17327  1.82856   32.85658  1.000 25.04205  ? 518 PHE   A CB   1 
ATOM   2232 C CG   . PHE   A 1 156 ? -7.19299  1.88062   31.76586  1.000 24.64611  ? 518 PHE   A CG   1 
ATOM   2233 C CD1  . PHE   A 1 156 ? -6.85533  2.30804   30.50366  1.000 27.47856  ? 518 PHE   A CD1  1 
ATOM   2234 C CD2  . PHE   A 1 156 ? -8.49246  1.47865   32.00747  1.000 31.49384  ? 518 PHE   A CD2  1 
ATOM   2235 C CE1  . PHE   A 1 156 ? -7.79985  2.34162   29.49396  1.000 27.40985  ? 518 PHE   A CE1  1 
ATOM   2236 C CE2  . PHE   A 1 156 ? -9.44224  1.51036   30.99463  1.000 33.75068  ? 518 PHE   A CE2  1 
ATOM   2237 C CZ   . PHE   A 1 156 ? -9.09518  1.93424   29.75587  1.000 28.35058  ? 518 PHE   A CZ   1 
ATOM   2238 H H    . PHE   A 1 156 ? -4.87839  4.01036   32.20140  1.000 28.78008  ? 518 PHE   A H    1 
ATOM   2239 H HA   . PHE   A 1 156 ? -6.79853  3.39329   34.01737  1.000 27.33597  ? 518 PHE   A HA   1 
ATOM   2240 H HB2  . PHE   A 1 156 ? -5.33096  1.55949   32.45779  1.000 30.06252  ? 518 PHE   A HB2  1 
ATOM   2241 H HB3  . PHE   A 1 156 ? -6.46434  1.16208   33.49844  1.000 30.06252  ? 518 PHE   A HB3  1 
ATOM   2242 H HD1  . PHE   A 1 156 ? -5.98290  2.57735   30.32695  1.000 32.98632  ? 518 PHE   A HD1  1 
ATOM   2243 H HD2  . PHE   A 1 156 ? -8.73344  1.18414   32.85605  1.000 37.80466  ? 518 PHE   A HD2  1 
ATOM   2244 H HE1  . PHE   A 1 156 ? -7.56521  2.63648   28.64372  1.000 32.90387  ? 518 PHE   A HE1  1 
ATOM   2245 H HE2  . PHE   A 1 156 ? -10.31554 1.24087   31.16677  1.000 40.51287  ? 518 PHE   A HE2  1 
ATOM   2246 H HZ   . PHE   A 1 156 ? -9.73143  1.95140   29.07779  1.000 34.03276  ? 518 PHE   A HZ   1 
ATOM   2247 N N    . ILE   A 1 157 ? -5.17882  3.31979   35.85268  1.000 26.40568  ? 519 ILE   A N    1 
ATOM   2248 C CA   . ILE   A 1 157 ? -4.29219  3.10836   36.98103  1.000 26.49363  ? 519 ILE   A CA   1 
ATOM   2249 C C    . ILE   A 1 157 ? -4.68740  1.80365   37.64172  1.000 27.22322  ? 519 ILE   A C    1 
ATOM   2250 O O    . ILE   A 1 157 ? -5.86815  1.53056   37.81782  1.000 30.97074  ? 519 ILE   A O    1 
ATOM   2251 C CB   . ILE   A 1 157 ? -4.36921  4.28585   37.96642  1.000 35.01892  ? 519 ILE   A CB   1 
ATOM   2252 C CG1  . ILE   A 1 157 ? -3.62836  5.48855   37.37318  1.000 36.87834  ? 519 ILE   A CG1  1 
ATOM   2253 C CG2  . ILE   A 1 157 ? -3.80092  3.90522   39.35518  1.000 30.12593  ? 519 ILE   A CG2  1 
ATOM   2254 C CD1  . ILE   A 1 157 ? -4.37952  6.72847   37.49488  1.000 42.87086  ? 519 ILE   A CD1  1 
ATOM   2255 H H    . ILE   A 1 157 ? -5.92876  3.67708   36.07524  1.000 31.69887  ? 519 ILE   A H    1 
ATOM   2256 H HA   . ILE   A 1 157 ? -3.37388  3.03720   36.67681  1.000 31.80441  ? 519 ILE   A HA   1 
ATOM   2257 H HB   . ILE   A 1 157 ? -5.30139  4.51885   38.09931  1.000 42.03476  ? 519 ILE   A HB   1 
ATOM   2258 H HG12 . ILE   A 1 157 ? -2.78522  5.60129   37.83934  1.000 44.26606  ? 519 ILE   A HG12 1 
ATOM   2259 H HG13 . ILE   A 1 157 ? -3.46717  5.32644   36.43050  1.000 44.26606  ? 519 ILE   A HG13 1 
ATOM   2260 H HG21 . ILE   A 1 157 ? -3.61011  4.71650   39.85148  1.000 36.16317  ? 519 ILE   A HG21 1 
ATOM   2261 H HG22 . ILE   A 1 157 ? -4.45841  3.37356   39.83053  1.000 36.16317  ? 519 ILE   A HG22 1 
ATOM   2262 H HG23 . ILE   A 1 157 ? -2.98646  3.39264   39.23344  1.000 36.16317  ? 519 ILE   A HG23 1 
ATOM   2263 H HD11 . ILE   A 1 157 ? -3.82489  7.46466   37.19272  1.000 51.45708  ? 519 ILE   A HD11 1 
ATOM   2264 H HD12 . ILE   A 1 157 ? -5.17779  6.66917   36.94702  1.000 51.45708  ? 519 ILE   A HD12 1 
ATOM   2265 H HD13 . ILE   A 1 157 ? -4.62506  6.85904   38.42416  1.000 51.45708  ? 519 ILE   A HD13 1 
ATOM   2266 N N    . HIS   A 1 158 ? -3.70256  1.00669   38.02126  1.000 29.69806  ? 520 HIS   A N    1 
ATOM   2267 C CA   . HIS   A 1 158 ? -4.00688  -0.28104  38.60589  1.000 29.56114  ? 520 HIS   A CA   1 
ATOM   2268 C C    . HIS   A 1 158 ? -4.89224  -0.10858  39.83390  1.000 29.86472  ? 520 HIS   A C    1 
ATOM   2269 O O    . HIS   A 1 158 ? -4.66079  0.76987   40.67227  1.000 29.50199  ? 520 HIS   A O    1 
ATOM   2270 C CB   . HIS   A 1 158 ? -2.72598  -1.01251  38.96875  1.000 30.09101  ? 520 HIS   A CB   1 
ATOM   2271 C CG   . HIS   A 1 158 ? -2.93196  -2.47935  39.10991  1.000 29.39437  ? 520 HIS   A CG   1 
ATOM   2272 N ND1  . HIS   A 1 158 ? -3.46138  -3.03617  40.24663  1.000 27.33145  ? 520 HIS   A ND1  1 
ATOM   2273 C CD2  . HIS   A 1 158 ? -2.74282  -3.50023  38.23891  1.000 28.99034  ? 520 HIS   A CD2  1 
ATOM   2274 C CE1  . HIS   A 1 158 ? -3.57698  -4.34154  40.08106  1.000 30.75310  ? 520 HIS   A CE1  1 
ATOM   2275 N NE2  . HIS   A 1 158 ? -3.12956  -4.64673  38.87849  1.000 28.15841  ? 520 HIS   A NE2  1 
ATOM   2276 H H    . HIS   A 1 158 ? -2.86454  1.18684   37.95150  1.000 35.64973  ? 520 HIS   A H    1 
ATOM   2277 H HA   . HIS   A 1 158 ? -4.48534  -0.82286  37.95905  1.000 35.48542  ? 520 HIS   A HA   1 
ATOM   2278 H HB2  . HIS   A 1 158 ? -2.06832  -0.86574  38.27101  1.000 36.12127  ? 520 HIS   A HB2  1 
ATOM   2279 H HB3  . HIS   A 1 158 ? -2.39451  -0.67144  39.81415  1.000 36.12127  ? 520 HIS   A HB3  1 
ATOM   2280 H HD2  . HIS   A 1 158 ? -2.41307  -3.43429  37.37183  1.000 34.80046  ? 520 HIS   A HD2  1 
ATOM   2281 H HE1  . HIS   A 1 158 ? -3.91563  -4.94214  40.70515  1.000 36.91578  ? 520 HIS   A HE1  1 
ATOM   2282 H HE2  . HIS   A 1 158 ? -3.08752  -5.43989  38.54874  1.000 33.80214  ? 520 HIS   A HE2  1 
ATOM   2283 N N    . GLU   A 1 159 ? -5.93596  -0.93897  39.92222  1.000 31.09162  ? 521 GLU   A N    1 
ATOM   2284 C CA   . GLU   A 1 159 ? -6.93286  -0.80278  40.97191  1.000 28.17947  ? 521 GLU   A CA   1 
ATOM   2285 C C    . GLU   A 1 159 ? -6.39054  -1.12123  42.36000  1.000 27.99763  ? 521 GLU   A C    1 
ATOM   2286 O O    . GLU   A 1 159 ? -7.06664  -0.85427  43.35451  1.000 34.30208  ? 521 GLU   A O    1 
ATOM   2287 C CB   . GLU   A 1 159 ? -8.14980  -1.69777  40.64932  1.000 33.91301  ? 521 GLU   A CB   1 
ATOM   2288 C CG   . GLU   A 1 159 ? -8.87195  -1.36119  39.31821  1.000 29.71716  ? 521 GLU   A CG   1 
ATOM   2289 C CD   . GLU   A 1 159 ? -8.13935  -1.83254  38.04598  1.000 37.70351  ? 521 GLU   A CD   1 
ATOM   2290 O OE1  . GLU   A 1 159 ? -7.23661  -2.68706  38.15591  1.000 31.85645  ? 521 GLU   A OE1  1 
ATOM   2291 O OE2  . GLU   A 1 159 ? -8.45797  -1.33275  36.93449  1.000 42.60792  ? 521 GLU   A OE2  1 
ATOM   2292 H H    . GLU   A 1 159 ? -6.08508  -1.59062  39.38118  1.000 37.32200  ? 521 GLU   A H    1 
ATOM   2293 H HA   . GLU   A 1 159 ? -7.23865  0.11746   40.99545  1.000 33.82742  ? 521 GLU   A HA   1 
ATOM   2294 H HB2  . GLU   A 1 159 ? -7.84840  -2.61802  40.59280  1.000 40.70766  ? 521 GLU   A HB2  1 
ATOM   2295 H HB3  . GLU   A 1 159 ? -8.79841  -1.60443  41.36450  1.000 40.70766  ? 521 GLU   A HB3  1 
ATOM   2296 H HG2  . GLU   A 1 159 ? -9.74441  -1.78506  39.32545  1.000 35.67265  ? 521 GLU   A HG2  1 
ATOM   2297 H HG3  . GLU   A 1 159 ? -8.97144  -0.39826  39.25676  1.000 35.67265  ? 521 GLU   A HG3  1 
ATOM   2298 N N    . GLY   A 1 160 ? -5.16574  -1.63276  42.45534  1.000 30.09581  ? 522 GLY   A N    1 
ATOM   2299 C CA   . GLY   A 1 160 ? -4.55442  -1.94742  43.72612  1.000 33.83371  ? 522 GLY   A CA   1 
ATOM   2300 C C    . GLY   A 1 160 ? -3.46928  -0.97887  44.04365  1.000 32.50894  ? 522 GLY   A C    1 
ATOM   2301 O O    . GLY   A 1 160 ? -2.75574  -1.18136  45.06326  1.000 33.62553  ? 522 GLY   A O    1 
ATOM   2302 H H    . GLY   A 1 160 ? -4.66421  -1.80750  41.77893  1.000 36.12702  ? 522 GLY   A H    1 
ATOM   2303 H HA2  . GLY   A 1 160 ? -5.22285  -1.91057  44.42807  1.000 40.61251  ? 522 GLY   A HA2  1 
ATOM   2304 H HA3  . GLY   A 1 160 ? -4.17801  -2.84087  43.69507  1.000 40.61251  ? 522 GLY   A HA3  1 
ATOM   2305 N N    . TYR   A 1 161 ? -3.26894  0.05804   43.24949  1.000 31.62286  ? 523 TYR   A N    1 
ATOM   2306 C CA   . TYR   A 1 161 ? -2.26320  1.06864   43.50122  1.000 33.33200  ? 523 TYR   A CA   1 
ATOM   2307 C C    . TYR   A 1 161 ? -2.87110  2.10235   44.43331  1.000 35.52402  ? 523 TYR   A C    1 
ATOM   2308 O O    . TYR   A 1 161 ? -3.98373  2.57878   44.18748  1.000 35.87996  ? 523 TYR   A O    1 
ATOM   2309 C CB   . TYR   A 1 161 ? -1.80742  1.73208   42.20084  1.000 30.92078  ? 523 TYR   A CB   1 
ATOM   2310 C CG   . TYR   A 1 161 ? -0.90417  2.92001   42.43098  1.000 35.34789  ? 523 TYR   A CG   1 
ATOM   2311 C CD1  . TYR   A 1 161 ? 0.39759   2.74202   42.86782  1.000 34.45432  ? 523 TYR   A CD1  1 
ATOM   2312 C CD2  . TYR   A 1 161 ? -1.34769  4.21861   42.21268  1.000 34.75945  ? 523 TYR   A CD2  1 
ATOM   2313 C CE1  . TYR   A 1 161 ? 1.22646   3.81641   43.10127  1.000 29.63385  ? 523 TYR   A CE1  1 
ATOM   2314 C CE2  . TYR   A 1 161 ? -0.51652  5.29265   42.43340  1.000 29.05489  ? 523 TYR   A CE2  1 
ATOM   2315 C CZ   . TYR   A 1 161 ? 0.78459   5.07274   42.87467  1.000 32.63274  ? 523 TYR   A CZ   1 
ATOM   2316 O OH   . TYR   A 1 161 ? 1.64732   6.14159   43.14235  1.000 29.39874  ? 523 TYR   A OH   1 
ATOM   2317 H H    . TYR   A 1 161 ? -3.72040  0.20269   42.53196  1.000 37.95949  ? 523 TYR   A H    1 
ATOM   2318 H HA   . TYR   A 1 161 ? -1.47895  0.67097   43.91076  1.000 40.01046  ? 523 TYR   A HA   1 
ATOM   2319 H HB2  . TYR   A 1 161 ? -1.31932  1.08303   41.67036  1.000 37.11698  ? 523 TYR   A HB2  1 
ATOM   2320 H HB3  . TYR   A 1 161 ? -2.58789  2.03921   41.71357  1.000 37.11698  ? 523 TYR   A HB3  1 
ATOM   2321 H HD1  . TYR   A 1 161 ? 0.71832   1.88011   43.00624  1.000 41.35724  ? 523 TYR   A HD1  1 
ATOM   2322 H HD2  . TYR   A 1 161 ? -2.21640  4.36348   41.91392  1.000 41.72339  ? 523 TYR   A HD2  1 
ATOM   2323 H HE1  . TYR   A 1 161 ? 2.09078   3.67716   43.41505  1.000 35.57267  ? 523 TYR   A HE1  1 
ATOM   2324 H HE2  . TYR   A 1 161 ? -0.82206  6.15903   42.28875  1.000 34.87792  ? 523 TYR   A HE2  1 
ATOM   2325 H HH   . TYR   A 1 161 ? 1.58610   6.71914   42.53549  1.000 35.29054  ? 523 TYR   A HH   1 
ATOM   2326 N N    . THR   A 1 162 ? -2.14659  2.43915   45.49761  1.000 33.27001  ? 524 THR   A N    1 
ATOM   2327 C CA   . THR   A 1 162 ? -2.54227  3.49563   46.42334  1.000 34.48436  ? 524 THR   A CA   1 
ATOM   2328 C C    . THR   A 1 162 ? -1.49149  4.59998   46.34413  1.000 31.60184  ? 524 THR   A C    1 
ATOM   2329 O O    . THR   A 1 162 ? -0.35761  4.41539   46.78997  1.000 38.68248  ? 524 THR   A O    1 
ATOM   2330 C CB   . THR   A 1 162 ? -2.69735  2.96365   47.84958  1.000 30.58393  ? 524 THR   A CB   1 
ATOM   2331 O OG1  . THR   A 1 162 ? -1.45022  2.46795   48.31714  1.000 36.29327  ? 524 THR   A OG1  1 
ATOM   2332 C CG2  . THR   A 1 162 ? -3.71506  1.83887   47.88758  1.000 31.32246  ? 524 THR   A CG2  1 
ATOM   2333 H H    . THR   A 1 162 ? -1.40401  2.06009   45.70855  1.000 39.93606  ? 524 THR   A H    1 
ATOM   2334 H HA   . THR   A 1 162 ? -3.39905  3.86265   46.15480  1.000 41.39328  ? 524 THR   A HA   1 
ATOM   2335 H HB   . THR   A 1 162 ? -3.00029  3.68188   48.42689  1.000 36.71277  ? 524 THR   A HB   1 
ATOM   2336 H HG1  . THR   A 1 162 ? -0.87328  3.07819   48.29846  1.000 43.56398  ? 524 THR   A HG1  1 
ATOM   2337 H HG21 . THR   A 1 162 ? -3.88602  1.57703   48.80579  1.000 37.59900  ? 524 THR   A HG21 1 
ATOM   2338 H HG22 . THR   A 1 162 ? -4.54714  2.13055   47.48328  1.000 37.59900  ? 524 THR   A HG22 1 
ATOM   2339 H HG23 . THR   A 1 162 ? -3.37956  1.07125   47.39859  1.000 37.59900  ? 524 THR   A HG23 1 
ATOM   2340 N N    . HIS   A 1 163 ? -1.87420  5.75920   45.80983  1.000 37.18931  ? 525 HIS   A N    1 
ATOM   2341 C CA   . HIS   A 1 163 ? -0.91399  6.83135   45.57690  1.000 35.46746  ? 525 HIS   A CA   1 
ATOM   2342 C C    . HIS   A 1 163 ? -0.36389  7.38194   46.87909  1.000 38.32575  ? 525 HIS   A C    1 
ATOM   2343 O O    . HIS   A 1 163 ? -1.11287  7.62321   47.82354  1.000 39.93806  ? 525 HIS   A O    1 
ATOM   2344 C CB   . HIS   A 1 163 ? -1.56434  7.97290   44.80881  1.000 37.98032  ? 525 HIS   A CB   1 
ATOM   2345 C CG   . HIS   A 1 163 ? -0.58456  8.94432   44.23607  1.000 39.62494  ? 525 HIS   A CG   1 
ATOM   2346 N ND1  . HIS   A 1 163 ? 0.39288   8.56429   43.34868  1.000 38.06856  ? 525 HIS   A ND1  1 
ATOM   2347 C CD2  . HIS   A 1 163 ? -0.44339  10.28126  44.40393  1.000 39.14456  ? 525 HIS   A CD2  1 
ATOM   2348 C CE1  . HIS   A 1 163 ? 1.09543   9.62248   42.98690  1.000 39.01359  ? 525 HIS   A CE1  1 
ATOM   2349 N NE2  . HIS   A 1 163 ? 0.60798   10.67713  43.61446  1.000 39.76827  ? 525 HIS   A NE2  1 
ATOM   2350 H H    . HIS   A 1 163 ? -2.67987  5.94752   45.57524  1.000 44.63923  ? 525 HIS   A H    1 
ATOM   2351 H HA   . HIS   A 1 163 ? -0.18009  6.46710   45.05765  1.000 42.57301  ? 525 HIS   A HA   1 
ATOM   2352 H HB2  . HIS   A 1 163 ? -2.07836  7.60231   44.07441  1.000 45.58844  ? 525 HIS   A HB2  1 
ATOM   2353 H HB3  . HIS   A 1 163 ? -2.14881  8.46075   45.40989  1.000 45.58844  ? 525 HIS   A HB3  1 
ATOM   2354 H HD2  . HIS   A 1 163 ? -0.96077  10.82758  44.95052  1.000 46.98553  ? 525 HIS   A HD2  1 
ATOM   2355 H HE1  . HIS   A 1 163 ? 1.81055   9.62451   42.39234  1.000 46.82836  ? 525 HIS   A HE1  1 
ATOM   2356 H HE2  . HIS   A 1 163 ? 0.90164   11.48206  43.54061  1.000 47.73398  ? 525 HIS   A HE2  1 
ATOM   2357 N N    . ASP   A 1 164 ? 0.96005   7.59231   46.91485  1.000 43.95153  ? 526 ASP   A N    1 
ATOM   2358 C CA   . ASP   A 1 164 ? 1.70252   8.11902   48.06677  1.000 48.15125  ? 526 ASP   A CA   1 
ATOM   2359 C C    . ASP   A 1 164 ? 1.61786   7.19573   49.28281  1.000 47.94466  ? 526 ASP   A C    1 
ATOM   2360 O O    . ASP   A 1 164 ? 1.95041   7.61145   50.40179  1.000 48.55224  ? 526 ASP   A O    1 
ATOM   2361 C CB   . ASP   A 1 164 ? 1.23813   9.53882   48.47668  1.000 46.51430  ? 526 ASP   A CB   1 
ATOM   2362 C CG   . ASP   A 1 164 ? 1.54232   10.61797  47.42758  1.000 49.52566  ? 526 ASP   A CG   1 
ATOM   2363 O OD1  . ASP   A 1 164 ? 2.51098   10.49783  46.63702  1.000 47.05429  ? 526 ASP   A OD1  1 
ATOM   2364 O OD2  . ASP   A 1 164 ? 0.76580   11.60120  47.38782  1.000 57.33041  ? 526 ASP   A OD2  1 
ATOM   2365 H H    . ASP   A 1 164 ? 1.47593   7.42797   46.24667  1.000 52.75389  ? 526 ASP   A H    1 
ATOM   2366 H HA   . ASP   A 1 164 ? 2.63072   8.18139   47.79209  1.000 57.79356  ? 526 ASP   A HA   1 
ATOM   2367 H HB2  . ASP   A 1 164 ? 0.27835   9.52492   48.61642  1.000 55.82921  ? 526 ASP   A HB2  1 
ATOM   2368 H HB3  . ASP   A 1 164 ? 1.68935   9.78968   49.29788  1.000 55.82921  ? 526 ASP   A HB3  1 
ATOM   2369 N N    . ALA   A 1 165 ? 1.20635   5.93339   49.08026  1.000 46.90102  ? 527 ALA   A N    1 
ATOM   2370 C CA   . ALA   A 1 165 ? 1.15053   4.93025   50.13991  1.000 42.24185  ? 527 ALA   A CA   1 
ATOM   2371 C C    . ALA   A 1 165 ? 1.76323   3.62997   49.60317  1.000 45.69664  ? 527 ALA   A C    1 
ATOM   2372 O O    . ALA   A 1 165 ? 1.06728   2.65480   49.30581  1.000 47.98621  ? 527 ALA   A O    1 
ATOM   2373 C CB   . ALA   A 1 165 ? -0.29041  4.73614   50.61892  1.000 42.36410  ? 527 ALA   A CB   1 
ATOM   2374 H H    . ALA   A 1 165 ? 0.94960   5.63391   48.31607  1.000 56.29328  ? 527 ALA   A H    1 
ATOM   2375 H HA   . ALA   A 1 165 ? 1.68561   5.21957   50.89548  1.000 50.70227  ? 527 ALA   A HA   1 
ATOM   2376 H HB1  . ALA   A 1 165 ? -0.31103  4.02456   51.27780  1.000 50.84897  ? 527 ALA   A HB1  1 
ATOM   2377 H HB2  . ALA   A 1 165 ? -0.60552  5.56338   51.01551  1.000 50.84897  ? 527 ALA   A HB2  1 
ATOM   2378 H HB3  . ALA   A 1 165 ? -0.84647  4.50035   49.85991  1.000 50.84897  ? 527 ALA   A HB3  1 
ATOM   2379 N N    . GLY   A 1 166 ? 3.08621   3.62169   49.48289  1.000 48.06898  ? 528 GLY   A N    1 
ATOM   2380 C CA   . GLY   A 1 166 ? 3.80052   2.49404   48.92924  1.000 36.65713  ? 528 GLY   A CA   1 
ATOM   2381 C C    . GLY   A 1 166 ? 3.68386   2.42375   47.41866  1.000 35.06289  ? 528 GLY   A C    1 
ATOM   2382 O O    . GLY   A 1 166 ? 2.87459   3.09899   46.78591  1.000 37.00395  ? 528 GLY   A O    1 
ATOM   2383 H H    . GLY   A 1 166 ? 3.59625   4.27195   49.72083  1.000 57.69483  ? 528 GLY   A H    1 
ATOM   2384 H HA2  . GLY   A 1 166 ? 4.73992   2.56372   49.16069  1.000 44.00062  ? 528 GLY   A HA2  1 
ATOM   2385 H HA3  . GLY   A 1 166 ? 3.44343   1.67293   49.30228  1.000 44.00062  ? 528 GLY   A HA3  1 
ATOM   2386 N N    . PHE   A 1 167 ? 4.50643   1.55526   46.83275  1.000 36.70396  ? 529 PHE   A N    1 
ATOM   2387 C CA   . PHE   A 1 167 ? 4.59298   1.43125   45.38441  1.000 38.24538  ? 529 PHE   A CA   1 
ATOM   2388 C C    . PHE   A 1 167 ? 4.11518   0.09127   44.84892  1.000 29.32599  ? 529 PHE   A C    1 
ATOM   2389 O O    . PHE   A 1 167 ? 4.33551   -0.20919  43.66887  1.000 31.83792  ? 529 PHE   A O    1 
ATOM   2390 C CB   . PHE   A 1 167 ? 6.02337   1.68682   44.94635  1.000 36.74053  ? 529 PHE   A CB   1 
ATOM   2391 C CG   . PHE   A 1 167 ? 6.43227   3.13335   45.05440  1.000 40.22761  ? 529 PHE   A CG   1 
ATOM   2392 C CD1  . PHE   A 1 167 ? 6.16560   4.03529   44.01301  1.000 35.32532  ? 529 PHE   A CD1  1 
ATOM   2393 C CD2  . PHE   A 1 167 ? 7.06188   3.59560   46.19679  1.000 36.96272  ? 529 PHE   A CD2  1 
ATOM   2394 C CE1  . PHE   A 1 167 ? 6.55203   5.36844   44.11607  1.000 38.56926  ? 529 PHE   A CE1  1 
ATOM   2395 C CE2  . PHE   A 1 167 ? 7.45372   4.91965   46.29890  1.000 44.13903  ? 529 PHE   A CE2  1 
ATOM   2396 C CZ   . PHE   A 1 167 ? 7.20555   5.80530   45.24024  1.000 41.18064  ? 529 PHE   A CZ   1 
ATOM   2397 H H    . PHE   A 1 167 ? 5.02890   1.02243   47.26020  1.000 44.05681  ? 529 PHE   A H    1 
ATOM   2398 H HA   . PHE   A 1 167 ? 4.01477   2.10288   44.99007  1.000 45.90651  ? 529 PHE   A HA   1 
ATOM   2399 H HB2  . PHE   A 1 167 ? 6.62034   1.16609   45.50614  1.000 44.10069  ? 529 PHE   A HB2  1 
ATOM   2400 H HB3  . PHE   A 1 167 ? 6.11982   1.41865   44.01916  1.000 44.10069  ? 529 PHE   A HB3  1 
ATOM   2401 H HD1  . PHE   A 1 167 ? 5.72716   3.73992   43.24787  1.000 42.40244  ? 529 PHE   A HD1  1 
ATOM   2402 H HD2  . PHE   A 1 167 ? 7.22326   3.01159   46.90233  1.000 44.36732  ? 529 PHE   A HD2  1 
ATOM   2403 H HE1  . PHE   A 1 167 ? 6.36755   5.96184   43.42416  1.000 46.29517  ? 529 PHE   A HE1  1 
ATOM   2404 H HE2  . PHE   A 1 167 ? 7.88070   5.22112   47.06812  1.000 52.97889  ? 529 PHE   A HE2  1 
ATOM   2405 H HZ   . PHE   A 1 167 ? 7.48454   6.69042   45.30045  1.000 49.42883  ? 529 PHE   A HZ   1 
ATOM   2406 N N    . ASP   A 1 168 ? 3.43969   -0.72098  45.65449  1.000 29.94235  ? 530 ASP   A N    1 
ATOM   2407 C CA   . ASP   A 1 168 ? 2.89143   -1.95341  45.11426  1.000 29.49813  ? 530 ASP   A CA   1 
ATOM   2408 C C    . ASP   A 1 168 ? 1.84199   -1.61922  44.05964  1.000 28.67677  ? 530 ASP   A C    1 
ATOM   2409 O O    . ASP   A 1 168 ? 1.06519   -0.67399  44.21033  1.000 28.01217  ? 530 ASP   A O    1 
ATOM   2410 C CB   . ASP   A 1 168 ? 2.29632   -2.80793  46.23804  1.000 30.51018  ? 530 ASP   A CB   1 
ATOM   2411 C CG   . ASP   A 1 168 ? 2.09586   -4.25398  45.83062  1.000 28.66501  ? 530 ASP   A CG   1 
ATOM   2412 O OD1  . ASP   A 1 168 ? 2.85849   -4.78695  44.98029  1.000 34.35249  ? 530 ASP   A OD1  1 
ATOM   2413 O OD2  . ASP   A 1 168 ? 1.14728   -4.87051  46.35726  1.000 33.32784  ? 530 ASP   A OD2  1 
ATOM   2414 H H    . ASP   A 1 168 ? 3.29065   -0.58430  46.49037  1.000 35.94287  ? 530 ASP   A H    1 
ATOM   2415 H HA   . ASP   A 1 168 ? 3.58955   -2.48118  44.69593  1.000 35.40981  ? 530 ASP   A HA   1 
ATOM   2416 H HB2  . ASP   A 1 168 ? 2.89668   -2.79125  46.99974  1.000 36.62428  ? 530 ASP   A HB2  1 
ATOM   2417 H HB3  . ASP   A 1 168 ? 1.43263   -2.44421  46.48833  1.000 36.62428  ? 530 ASP   A HB3  1 
ATOM   2418 N N    . ASN   A 1 169 ? 1.89397   -2.35593  42.94823  1.000 29.65695  ? 531 ASN   A N    1 
ATOM   2419 C CA   . ASN   A 1 169 ? 0.98130   -2.21662  41.81146  1.000 24.78704  ? 531 ASN   A CA   1 
ATOM   2420 C C    . ASN   A 1 169 ? 1.17076   -0.89643  41.07606  1.000 28.94615  ? 531 ASN   A C    1 
ATOM   2421 O O    . ASN   A 1 169 ? 0.20905   -0.32469  40.55225  1.000 26.95449  ? 531 ASN   A O    1 
ATOM   2422 C CB   . ASN   A 1 169 ? -0.47503  -2.36051  42.23328  1.000 27.82778  ? 531 ASN   A CB   1 
ATOM   2423 C CG   . ASN   A 1 169 ? -0.74889  -3.67082  42.96509  1.000 29.91352  ? 531 ASN   A CG   1 
ATOM   2424 O OD1  . ASN   A 1 169 ? -0.40706  -4.73967  42.47984  1.000 28.92886  ? 531 ASN   A OD1  1 
ATOM   2425 N ND2  . ASN   A 1 169 ? -1.38992  -3.57941  44.12206  1.000 26.63167  ? 531 ASN   A ND2  1 
ATOM   2426 H H    . ASN   A 1 169 ? 2.47837   -2.97417  42.82230  1.000 35.60040  ? 531 ASN   A H    1 
ATOM   2427 H HA   . ASN   A 1 169 ? 1.19600   -2.93037  41.19069  1.000 29.75650  ? 531 ASN   A HA   1 
ATOM   2428 H HB2  . ASN   A 1 169 ? -0.70561  -1.63024  42.82862  1.000 33.40539  ? 531 ASN   A HB2  1 
ATOM   2429 H HB3  . ASN   A 1 169 ? -1.03727  -2.33465  41.44326  1.000 33.40539  ? 531 ASN   A HB3  1 
ATOM   2430 H HD21 . ASN   A 1 169 ? -1.56768  -4.29013  44.57248  1.000 31.97006  ? 531 ASN   A HD21 1 
ATOM   2431 H HD22 . ASN   A 1 169 ? -1.62795  -2.80940  44.42210  1.000 31.97006  ? 531 ASN   A HD22 1 
ATOM   2432 N N    . ASP   A 1 170 ? 2.42613   -0.45444  40.99189  1.000 26.61006  ? 532 ASP   A N    1 
ATOM   2433 C CA   . ASP   A 1 170 ? 2.80335   0.79597   40.34144  1.000 26.79447  ? 532 ASP   A CA   1 
ATOM   2434 C C    . ASP   A 1 170 ? 2.85493   0.55967   38.83850  1.000 25.48307  ? 532 ASP   A C    1 
ATOM   2435 O O    . ASP   A 1 170 ? 3.92076   0.41488   38.23063  1.000 24.91669  ? 532 ASP   A O    1 
ATOM   2436 C CB   . ASP   A 1 170 ? 4.15063   1.27848   40.87370  1.000 22.97071  ? 532 ASP   A CB   1 
ATOM   2437 C CG   . ASP   A 1 170 ? 4.49015   2.70545   40.45721  1.000 31.57931  ? 532 ASP   A CG   1 
ATOM   2438 O OD1  . ASP   A 1 170 ? 3.60293   3.41358   39.93495  1.000 27.77801  ? 532 ASP   A OD1  1 
ATOM   2439 O OD2  . ASP   A 1 170 ? 5.64796   3.14071   40.70893  1.000 25.83629  ? 532 ASP   A OD2  1 
ATOM   2440 H H    . ASP   A 1 170 ? 3.10046   -0.87813  41.31649  1.000 31.94412  ? 532 ASP   A H    1 
ATOM   2441 H HA   . ASP   A 1 170 ? 2.13199   1.47156   40.52514  1.000 32.16541  ? 532 ASP   A HA   1 
ATOM   2442 H HB2  . ASP   A 1 170 ? 4.13414   1.24772   41.84307  1.000 27.57691  ? 532 ASP   A HB2  1 
ATOM   2443 H HB3  . ASP   A 1 170 ? 4.84846   0.69601   40.53510  1.000 27.57691  ? 532 ASP   A HB3  1 
ATOM   2444 N N    . ILE   A 1 171 ? 1.68147   0.54368   38.22789  1.000 26.46604  ? 533 ILE   A N    1 
ATOM   2445 C CA   . ILE   A 1 171 ? 1.56795   0.26179   36.80121  1.000 24.19285  ? 533 ILE   A CA   1 
ATOM   2446 C C    . ILE   A 1 171 ? 0.32037   0.94091   36.27396  1.000 26.09193  ? 533 ILE   A C    1 
ATOM   2447 O O    . ILE   A 1 171 ? -0.71624  0.94068   36.93346  1.000 28.02370  ? 533 ILE   A O    1 
ATOM   2448 C CB   . ILE   A 1 171 ? 1.53412   -1.25048  36.55035  1.000 22.97209  ? 533 ILE   A CB   1 
ATOM   2449 C CG1  . ILE   A 1 171 ? 1.53898   -1.55280  35.06765  1.000 32.48470  ? 533 ILE   A CG1  1 
ATOM   2450 C CG2  . ILE   A 1 171 ? 0.31342   -1.92603  37.18298  1.000 27.74672  ? 533 ILE   A CG2  1 
ATOM   2451 C CD1  . ILE   A 1 171 ? 1.85515   -3.06240  34.76538  1.000 31.59442  ? 533 ILE   A CD1  1 
ATOM   2452 H H    . ILE   A 1 171 ? 0.92986   0.69359   38.61804  1.000 31.77130  ? 533 ILE   A H    1 
ATOM   2453 H HA   . ILE   A 1 171 ? 2.32943   0.63742   36.33223  1.000 29.04347  ? 533 ILE   A HA   1 
ATOM   2454 H HB   . ILE   A 1 171 ? 2.33446   -1.60536  36.96798  1.000 27.57856  ? 533 ILE   A HB   1 
ATOM   2455 H HG12 . ILE   A 1 171 ? 0.66537   -1.34777  34.69932  1.000 38.99370  ? 533 ILE   A HG12 1 
ATOM   2456 H HG13 . ILE   A 1 171 ? 2.21691   -1.01004  34.63554  1.000 38.99370  ? 533 ILE   A HG13 1 
ATOM   2457 H HG21 . ILE   A 1 171 ? 0.46228   -2.88411  37.21186  1.000 33.30812  ? 533 ILE   A HG21 1 
ATOM   2458 H HG22 . ILE   A 1 171 ? 0.19313   -1.58273  38.08219  1.000 33.30812  ? 533 ILE   A HG22 1 
ATOM   2459 H HG23 . ILE   A 1 171 ? -0.47011  -1.72906  36.64615  1.000 33.30812  ? 533 ILE   A HG23 1 
ATOM   2460 H HD11 . ILE   A 1 171 ? 1.89085   -3.19134  33.80465  1.000 37.92536  ? 533 ILE   A HD11 1 
ATOM   2461 H HD12 . ILE   A 1 171 ? 2.71027   -3.29148  35.16187  1.000 37.92536  ? 533 ILE   A HD12 1 
ATOM   2462 H HD13 . ILE   A 1 171 ? 1.15493   -3.61434  35.14741  1.000 37.92536  ? 533 ILE   A HD13 1 
ATOM   2463 N N    . ALA   A 1 172 ? 0.41473   1.48592   35.06452  1.000 23.15908  ? 534 ALA   A N    1 
ATOM   2464 C CA   . ALA   A 1 172 ? -0.70248  2.19727   34.46599  1.000 24.14378  ? 534 ALA   A CA   1 
ATOM   2465 C C    . ALA   A 1 172 ? -0.60964  1.98057   32.96568  1.000 25.99246  ? 534 ALA   A C    1 
ATOM   2466 O O    . ALA   A 1 172 ? 0.46932   1.71929   32.43198  1.000 22.38141  ? 534 ALA   A O    1 
ATOM   2467 C CB   . ALA   A 1 172 ? -0.68510  3.68945   34.83452  1.000 25.10689  ? 534 ALA   A CB   1 
ATOM   2468 H H    . ALA   A 1 172 ? 1.11862   1.45570   34.57134  1.000 27.80295  ? 534 ALA   A H    1 
ATOM   2469 H HA   . ALA   A 1 172 ? -1.55332  1.84954   34.77593  1.000 28.98459  ? 534 ALA   A HA   1 
ATOM   2470 H HB1  . ALA   A 1 172 ? -1.40339  4.13958   34.36300  1.000 30.14032  ? 534 ALA   A HB1  1 
ATOM   2471 H HB2  . ALA   A 1 172 ? -0.81047  3.77971   35.79214  1.000 30.14032  ? 534 ALA   A HB2  1 
ATOM   2472 H HB3  . ALA   A 1 172 ? 0.16928   4.06876   34.57557  1.000 30.14032  ? 534 ALA   A HB3  1 
ATOM   2473 N N    . LEU   A 1 173 ? -1.76204  2.01368   32.30324  1.000 25.39903  ? 535 LEU   A N    1 
ATOM   2474 C CA   . LEU   A 1 173 ? -1.83970  1.98612   30.85166  1.000 24.19474  ? 535 LEU   A CA   1 
ATOM   2475 C C    . LEU   A 1 173 ? -2.54003  3.24570   30.35509  1.000 28.00476  ? 535 LEU   A C    1 
ATOM   2476 O O    . LEU   A 1 173 ? -3.55807  3.67150   30.91196  1.000 26.50412  ? 535 LEU   A O    1 
ATOM   2477 C CB   . LEU   A 1 173 ? -2.60076  0.76940   30.36007  1.000 26.26611  ? 535 LEU   A CB   1 
ATOM   2478 C CG   . LEU   A 1 173 ? -1.80874  -0.51765  30.21832  1.000 23.90798  ? 535 LEU   A CG   1 
ATOM   2479 C CD1  . LEU   A 1 173 ? -2.75003  -1.65632  30.01963  1.000 24.39309  ? 535 LEU   A CD1  1 
ATOM   2480 C CD2  . LEU   A 1 173 ? -0.85218  -0.42144  29.05989  1.000 24.29769  ? 535 LEU   A CD2  1 
ATOM   2481 H H    . LEU   A 1 173 ? -2.53127  2.05325   32.68577  1.000 30.49089  ? 535 LEU   A H    1 
ATOM   2482 H HA   . LEU   A 1 173 ? -0.94186  1.95742   30.48566  1.000 29.04574  ? 535 LEU   A HA   1 
ATOM   2483 H HB2  . LEU   A 1 173 ? -3.32052  0.59293   30.98593  1.000 31.53138  ? 535 LEU   A HB2  1 
ATOM   2484 H HB3  . LEU   A 1 173 ? -2.96511  0.97690   29.48537  1.000 31.53138  ? 535 LEU   A HB3  1 
ATOM   2485 H HG   . LEU   A 1 173 ? -1.28860  -0.67337  31.02214  1.000 28.70163  ? 535 LEU   A HG   1 
ATOM   2486 H HD11 . LEU   A 1 173 ? -2.23915  -2.47518  29.92283  1.000 29.28376  ? 535 LEU   A HD11 1 
ATOM   2487 H HD12 . LEU   A 1 173 ? -3.33508  -1.72065  30.79065  1.000 29.28376  ? 535 LEU   A HD12 1 
ATOM   2488 H HD13 . LEU   A 1 173 ? -3.27410  -1.49683  29.21912  1.000 29.28376  ? 535 LEU   A HD13 1 
ATOM   2489 H HD21 . LEU   A 1 173 ? -0.44643  -1.29007  28.91240  1.000 29.16928  ? 535 LEU   A HD21 1 
ATOM   2490 H HD22 . LEU   A 1 173 ? -1.34109  -0.14609  28.26866  1.000 29.16928  ? 535 LEU   A HD22 1 
ATOM   2491 H HD23 . LEU   A 1 173 ? -0.16702  0.23238   29.26957  1.000 29.16928  ? 535 LEU   A HD23 1 
ATOM   2492 N N    . ILE   A 1 174 ? -1.98954  3.83180   29.30115  1.000 25.13371  ? 536 ILE   A N    1 
ATOM   2493 C CA   . ILE   A 1 174 ? -2.55272  4.99867   28.64933  1.000 26.59722  ? 536 ILE   A CA   1 
ATOM   2494 C C    . ILE   A 1 174 ? -2.97131  4.57976   27.25883  1.000 31.80834  ? 536 ILE   A C    1 
ATOM   2495 O O    . ILE   A 1 174 ? -2.14038  4.07203   26.49669  1.000 25.01774  ? 536 ILE   A O    1 
ATOM   2496 C CB   . ILE   A 1 174 ? -1.53545  6.13851   28.56274  1.000 28.12306  ? 536 ILE   A CB   1 
ATOM   2497 C CG1  . ILE   A 1 174 ? -1.12602  6.59970   29.96479  1.000 31.05901  ? 536 ILE   A CG1  1 
ATOM   2498 C CG2  . ILE   A 1 174 ? -2.11251  7.28256   27.72951  1.000 26.87798  ? 536 ILE   A CG2  1 
ATOM   2499 C CD1  . ILE   A 1 174 ? 0.31553   7.11685   30.00838  1.000 35.91454  ? 536 ILE   A CD1  1 
ATOM   2500 H H    . ILE   A 1 174 ? -1.26147  3.55903   28.93356  1.000 30.17250  ? 536 ILE   A H    1 
ATOM   2501 H HA   . ILE   A 1 174 ? -3.32837  5.30213   29.14651  1.000 31.92872  ? 536 ILE   A HA   1 
ATOM   2502 H HB   . ILE   A 1 174 ? -0.73290  5.81970   28.12096  1.000 33.75973  ? 536 ILE   A HB   1 
ATOM   2503 H HG12 . ILE   A 1 174 ? -1.71357  7.31807   30.24700  1.000 37.28287  ? 536 ILE   A HG12 1 
ATOM   2504 H HG13 . ILE   A 1 174 ? -1.19766  5.85202   30.57858  1.000 37.28287  ? 536 ILE   A HG13 1 
ATOM   2505 H HG21 . ILE   A 1 174 ? -1.71147  8.11718   28.01843  1.000 32.26563  ? 536 ILE   A HG21 1 
ATOM   2506 H HG22 . ILE   A 1 174 ? -1.91055  7.12495   26.79395  1.000 32.26563  ? 536 ILE   A HG22 1 
ATOM   2507 H HG23 . ILE   A 1 174 ? -3.07320  7.31469   27.85966  1.000 32.26563  ? 536 ILE   A HG23 1 
ATOM   2508 H HD11 . ILE   A 1 174 ? 0.50731   7.44259   30.90170  1.000 43.10950  ? 536 ILE   A HD11 1 
ATOM   2509 H HD12 . ILE   A 1 174 ? 0.91844   6.39069   29.78456  1.000 43.10950  ? 536 ILE   A HD12 1 
ATOM   2510 H HD13 . ILE   A 1 174 ? 0.41224   7.83704   29.36583  1.000 43.10950  ? 536 ILE   A HD13 1 
ATOM   2511 N N    . LYS   A 1 175 ? -4.24789  4.80252   26.92790  1.000 26.50696  ? 537 LYS   A N    1 
ATOM   2512 C CA   . LYS   A 1 175 ? -4.74195  4.64736   25.56880  1.000 27.97314  ? 537 LYS   A CA   1 
ATOM   2513 C C    . LYS   A 1 175 ? -4.57068  5.97331   24.84568  1.000 29.02889  ? 537 LYS   A C    1 
ATOM   2514 O O    . LYS   A 1 175 ? -4.99555  7.02274   25.34764  1.000 30.43821  ? 537 LYS   A O    1 
ATOM   2515 C CB   . LYS   A 1 175 ? -6.21382  4.21889   25.54369  1.000 31.03614  ? 537 LYS   A CB   1 
ATOM   2516 C CG   . LYS   A 1 175 ? -6.65055  3.74491   24.13281  1.000 31.39684  ? 537 LYS   A CG   1 
ATOM   2517 C CD   . LYS   A 1 175 ? -8.03103  3.12144   24.08643  1.000 42.81323  ? 537 LYS   A CD   1 
ATOM   2518 C CE   . LYS   A 1 175 ? -8.45862  2.83038   22.62636  1.000 49.55781  ? 537 LYS   A CE   1 
ATOM   2519 N NZ   . LYS   A 1 175 ? -9.89734  3.10858   22.39190  1.000 60.41823  ? 537 LYS   A NZ   1 
ATOM   2520 H H    . LYS   A 1 175 ? -4.85285  5.04855   27.48745  1.000 31.82040  ? 537 LYS   A H    1 
ATOM   2521 H HA   . LYS   A 1 175 ? -4.23625  3.95489   25.11531  1.000 33.57983  ? 537 LYS   A HA   1 
ATOM   2522 H HB2  . LYS   A 1 175 ? -6.34378  3.48557   26.16518  1.000 37.25542  ? 537 LYS   A HB2  1 
ATOM   2523 H HB3  . LYS   A 1 175 ? -6.77014  4.97175   25.79789  1.000 37.25542  ? 537 LYS   A HB3  1 
ATOM   2524 H HG2  . LYS   A 1 175 ? -6.65354  4.50897   23.53522  1.000 37.68826  ? 537 LYS   A HG2  1 
ATOM   2525 H HG3  . LYS   A 1 175 ? -6.01782  3.08031   23.81839  1.000 37.68826  ? 537 LYS   A HG3  1 
ATOM   2526 H HD2  . LYS   A 1 175 ? -8.02466  2.28478   24.57721  1.000 51.38794  ? 537 LYS   A HD2  1 
ATOM   2527 H HD3  . LYS   A 1 175 ? -8.67478  3.73155   24.47919  1.000 51.38794  ? 537 LYS   A HD3  1 
ATOM   2528 H HE2  . LYS   A 1 175 ? -7.94186  3.39063   22.02638  1.000 59.48143  ? 537 LYS   A HE2  1 
ATOM   2529 H HE3  . LYS   A 1 175 ? -8.29666  1.89469   22.42849  1.000 59.48143  ? 537 LYS   A HE3  1 
ATOM   2530 H HZ1  . LYS   A 1 175 ? -10.11315 2.90842   21.55198  1.000 72.51394  ? 537 LYS   A HZ1  1 
ATOM   2531 H HZ2  . LYS   A 1 175 ? -10.39585 2.61860   22.94281  1.000 72.51394  ? 537 LYS   A HZ2  1 
ATOM   2532 H HZ3  . LYS   A 1 175 ? -10.06835 3.96992   22.53663  1.000 72.51394  ? 537 LYS   A HZ3  1 
ATOM   2533 N N    . LEU   A 1 176 ? -3.88745  5.93268   23.71108  1.000 26.41534  ? 538 LEU   A N    1 
ATOM   2534 C CA   . LEU   A 1 176 ? -3.68453  7.12190   22.90374  1.000 29.55279  ? 538 LEU   A CA   1 
ATOM   2535 C C    . LEU   A 1 176 ? -4.94377  7.38988   22.09314  1.000 39.42894  ? 538 LEU   A C    1 
ATOM   2536 O O    . LEU   A 1 176 ? -5.64323  6.45724   21.70692  1.000 29.96116  ? 538 LEU   A O    1 
ATOM   2537 C CB   . LEU   A 1 176 ? -2.49780  6.92667   21.97063  1.000 28.56835  ? 538 LEU   A CB   1 
ATOM   2538 C CG   . LEU   A 1 176 ? -1.17017  6.53539   22.64017  1.000 28.97253  ? 538 LEU   A CG   1 
ATOM   2539 C CD1  . LEU   A 1 176 ? -0.08552  6.49108   21.59905  1.000 30.42853  ? 538 LEU   A CD1  1 
ATOM   2540 C CD2  . LEU   A 1 176 ? -0.80761  7.49010   23.75966  1.000 28.80641  ? 538 LEU   A CD2  1 
ATOM   2541 H H    . LEU   A 1 176 ? -3.52874  5.22224   23.38520  1.000 31.71047  ? 538 LEU   A H    1 
ATOM   2542 H HA   . LEU   A 1 176 ? -3.49673  7.89040   23.46503  1.000 35.47540  ? 538 LEU   A HA   1 
ATOM   2543 H HB2  . LEU   A 1 176 ? -2.72049  6.22266   21.34161  1.000 34.29407  ? 538 LEU   A HB2  1 
ATOM   2544 H HB3  . LEU   A 1 176 ? -2.34582  7.75922   21.49664  1.000 34.29407  ? 538 LEU   A HB3  1 
ATOM   2545 H HG   . LEU   A 1 176 ? -1.26036  5.65749   23.04274  1.000 34.77909  ? 538 LEU   A HG   1 
ATOM   2546 H HD11 . LEU   A 1 176 ? 0.75301   6.25623   22.02640  1.000 36.52629  ? 538 LEU   A HD11 1 
ATOM   2547 H HD12 . LEU   A 1 176 ? -0.31486  5.82502   20.93222  1.000 36.52629  ? 538 LEU   A HD12 1 
ATOM   2548 H HD13 . LEU   A 1 176 ? -0.01149  7.36408   21.18277  1.000 36.52629  ? 538 LEU   A HD13 1 
ATOM   2549 H HD21 . LEU   A 1 176 ? 0.10073   7.30873   24.04762  1.000 34.57975  ? 538 LEU   A HD21 1 
ATOM   2550 H HD22 . LEU   A 1 176 ? -0.87529  8.40073   23.43245  1.000 34.57975  ? 538 LEU   A HD22 1 
ATOM   2551 H HD23 . LEU   A 1 176 ? -1.42160  7.35773   24.49885  1.000 34.57975  ? 538 LEU   A HD23 1 
ATOM   2552 N N    . ASN   A 1 177 ? -5.22762  8.66756   21.81997  1.000 38.96681  ? 539 ASN   A N    1 
ATOM   2553 C CA   . ASN   A 1 177 ? -6.41844  8.93580   21.01858  1.000 48.77454  ? 539 ASN   A CA   1 
ATOM   2554 C C    . ASN   A 1 177 ? -6.20513  8.67860   19.53527  1.000 49.03432  ? 539 ASN   A C    1 
ATOM   2555 O O    . ASN   A 1 177 ? -7.18447  8.67911   18.78616  1.000 52.61455  ? 539 ASN   A O    1 
ATOM   2556 C CB   . ASN   A 1 177 ? -6.95231  10.36190  21.18548  1.000 52.63456  ? 539 ASN   A CB   1 
ATOM   2557 C CG   . ASN   A 1 177 ? -5.90350  11.41927  21.04196  1.000 61.61888  ? 539 ASN   A CG   1 
ATOM   2558 O OD1  . ASN   A 1 177 ? -4.81532  11.18907  20.50587  1.000 59.54520  ? 539 ASN   A OD1  1 
ATOM   2559 N ND2  . ASN   A 1 177 ? -6.27328  12.63488  21.43043  1.000 72.40780  ? 539 ASN   A ND2  1 
ATOM   2560 H H    . ASN   A 1 177 ? -4.77253  9.35201   22.07298  1.000 46.77222  ? 539 ASN   A H    1 
ATOM   2561 H HA   . ASN   A 1 177 ? -7.10646  8.34332   21.35990  1.000 58.54151  ? 539 ASN   A HA   1 
ATOM   2562 H HB2  . ASN   A 1 177 ? -7.62897  10.52304  20.50941  1.000 63.17353  ? 539 ASN   A HB2  1 
ATOM   2563 H HB3  . ASN   A 1 177 ? -7.34019  10.44847  22.07033  1.000 63.17353  ? 539 ASN   A HB3  1 
ATOM   2564 H HD21 . ASN   A 1 177 ? -7.06613  12.76578  21.73679  1.000 86.90141  ? 539 ASN   A HD21 1 
ATOM   2565 H HD22 . ASN   A 1 177 ? -5.71978  13.29079  21.37551  1.000 86.90141  ? 539 ASN   A HD22 1 
ATOM   2566 N N    . ASN   A 1 178 ? -4.96879  8.45667   19.08928  1.000 44.68112  ? 540 ASN   A N    1 
ATOM   2567 C CA   . ASN   A 1 178 ? -4.71760  8.04428   17.71727  1.000 45.94516  ? 540 ASN   A CA   1 
ATOM   2568 C C    . ASN   A 1 178 ? -3.57425  7.04363   17.69892  1.000 38.50985  ? 540 ASN   A C    1 
ATOM   2569 O O    . ASN   A 1 178 ? -2.66919  7.09451   18.52958  1.000 43.26187  ? 540 ASN   A O    1 
ATOM   2570 C CB   . ASN   A 1 178 ? -4.36148  9.22030   16.79213  1.000 50.63018  ? 540 ASN   A CB   1 
ATOM   2571 C CG   . ASN   A 1 178 ? -5.57375  10.06885  16.41730  1.000 62.56340  ? 540 ASN   A CG   1 
ATOM   2572 O OD1  . ASN   A 1 178 ? -6.67147  9.55474   16.20976  1.000 58.70521  ? 540 ASN   A OD1  1 
ATOM   2573 N ND2  . ASN   A 1 178 ? -5.37351  11.37665  16.33433  1.000 69.14740  ? 540 ASN   A ND2  1 
ATOM   2574 H H    . ASN   A 1 178 ? -4.25884  8.53970   19.56748  1.000 53.62940  ? 540 ASN   A H    1 
ATOM   2575 H HA   . ASN   A 1 178 ? -5.52219  7.62559   17.37340  1.000 55.14625  ? 540 ASN   A HA   1 
ATOM   2576 H HB2  . ASN   A 1 178 ? -3.72223  9.79402   17.24279  1.000 60.76827  ? 540 ASN   A HB2  1 
ATOM   2577 H HB3  . ASN   A 1 178 ? -3.97512  8.87201   15.97340  1.000 60.76827  ? 540 ASN   A HB3  1 
ATOM   2578 H HD21 . ASN   A 1 178 ? -6.02432  11.89897  16.12642  1.000 82.98893  ? 540 ASN   A HD21 1 
ATOM   2579 H HD22 . ASN   A 1 178 ? -4.59280  11.70275  16.48842  1.000 82.98893  ? 540 ASN   A HD22 1 
ATOM   2580 N N    . LYS   A 1 179 ? -3.62534  6.13595   16.74081  1.000 33.74540  ? 541 LYS   A N    1 
ATOM   2581 C CA   . LYS   A 1 179 ? -2.47682  5.28762   16.48253  1.000 38.58824  ? 541 LYS   A CA   1 
ATOM   2582 C C    . LYS   A 1 179 ? -1.28149  6.14016   16.05902  1.000 36.93910  ? 541 LYS   A C    1 
ATOM   2583 O O    . LYS   A 1 179 ? -1.43220  7.10038   15.30411  1.000 32.67636  ? 541 LYS   A O    1 
ATOM   2584 C CB   . LYS   A 1 179 ? -2.79677  4.28375   15.37824  1.000 30.97536  ? 541 LYS   A CB   1 
ATOM   2585 C CG   . LYS   A 1 179 ? -3.90616  3.29985   15.67164  1.000 39.25444  ? 541 LYS   A CG   1 
ATOM   2586 C CD   . LYS   A 1 179 ? -3.98996  2.24465   14.56727  1.000 45.45087  ? 541 LYS   A CD   1 
ATOM   2587 C CE   . LYS   A 1 179 ? -4.30364  0.80920   15.06790  1.000 51.35701  ? 541 LYS   A CE   1 
ATOM   2588 N NZ   . LYS   A 1 179 ? -3.50896  -0.20657  14.27657  1.000 50.28656  ? 541 LYS   A NZ   1 
ATOM   2589 H H    . LYS   A 1 179 ? -4.30362  5.99215   16.23203  1.000 40.50654  ? 541 LYS   A H    1 
ATOM   2590 H HA   . LYS   A 1 179 ? -2.25144  4.79804   17.28902  1.000 46.31794  ? 541 LYS   A HA   1 
ATOM   2591 H HB2  . LYS   A 1 179 ? -3.05635  4.77890   14.58555  1.000 37.18248  ? 541 LYS   A HB2  1 
ATOM   2592 H HB3  . LYS   A 1 179 ? -1.99614  3.76635   15.19884  1.000 37.18248  ? 541 LYS   A HB3  1 
ATOM   2593 H HG2  . LYS   A 1 179 ? -3.72999  2.85256   16.51413  1.000 47.11739  ? 541 LYS   A HG2  1 
ATOM   2594 H HG3  . LYS   A 1 179 ? -4.75393  3.76912   15.71608  1.000 47.11739  ? 541 LYS   A HG3  1 
ATOM   2595 H HD2  . LYS   A 1 179 ? -4.69352  2.49838   13.94959  1.000 54.55310  ? 541 LYS   A HD2  1 
ATOM   2596 H HD3  . LYS   A 1 179 ? -3.13799  2.21255   14.10466  1.000 54.55310  ? 541 LYS   A HD3  1 
ATOM   2597 H HE2  . LYS   A 1 179 ? -4.06258  0.73063   16.00418  1.000 61.64046  ? 541 LYS   A HE2  1 
ATOM   2598 H HE3  . LYS   A 1 179 ? -5.24844  0.62274   14.95179  1.000 61.64046  ? 541 LYS   A HE3  1 
ATOM   2599 H HZ1  . LYS   A 1 179 ? -3.68457  -1.02753  14.57198  1.000 60.35593  ? 541 LYS   A HZ1  1 
ATOM   2600 H HZ2  . LYS   A 1 179 ? -3.72493  -0.15743  13.41457  1.000 60.35593  ? 541 LYS   A HZ2  1 
ATOM   2601 H HZ3  . LYS   A 1 179 ? -2.63777  -0.04777  14.36556  1.000 60.35593  ? 541 LYS   A HZ3  1 
ATOM   2602 N N    . VAL   A 1 180 ? -0.07500  5.76017   16.51548  1.000 36.86677  ? 542 VAL   A N    1 
ATOM   2603 C CA   . VAL   A 1 180 ? 1.17115   6.35071   16.01627  1.000 36.00597  ? 542 VAL   A CA   1 
ATOM   2604 C C    . VAL   A 1 180 ? 1.67873   5.49238   14.86384  1.000 36.19252  ? 542 VAL   A C    1 
ATOM   2605 O O    . VAL   A 1 180 ? 1.40806   4.28606   14.78770  1.000 32.75100  ? 542 VAL   A O    1 
ATOM   2606 C CB   . VAL   A 1 180 ? 2.29696   6.47930   17.08903  1.000 37.23651  ? 542 VAL   A CB   1 
ATOM   2607 C CG1  . VAL   A 1 180 ? 2.05923   7.68249   18.01381  1.000 43.92327  ? 542 VAL   A CG1  1 
ATOM   2608 C CG2  . VAL   A 1 180 ? 2.48245   5.17212   17.89558  1.000 33.28037  ? 542 VAL   A CG2  1 
ATOM   2609 H H    . VAL   A 1 180 ? 0.04466   5.15822   17.11793  1.000 44.25218  ? 542 VAL   A H    1 
ATOM   2610 H HA   . VAL   A 1 180 ? 0.95614   7.24747   15.71547  1.000 43.21922  ? 542 VAL   A HA   1 
ATOM   2611 H HB   . VAL   A 1 180 ? 3.12970   6.63744   16.61740  1.000 44.69586  ? 542 VAL   A HB   1 
ATOM   2612 H HG11 . VAL   A 1 180 ? 2.77960   7.73006   18.66165  1.000 52.71998  ? 542 VAL   A HG11 1 
ATOM   2613 H HG12 . VAL   A 1 180 ? 2.04039   8.49220   17.48003  1.000 52.71998  ? 542 VAL   A HG12 1 
ATOM   2614 H HG13 . VAL   A 1 180 ? 1.21105   7.56733   18.47014  1.000 52.71998  ? 542 VAL   A HG13 1 
ATOM   2615 H HG21 . VAL   A 1 180 ? 3.23104   5.27938   18.50304  1.000 39.94850  ? 542 VAL   A HG21 1 
ATOM   2616 H HG22 . VAL   A 1 180 ? 1.67204   4.99314   18.39767  1.000 39.94850  ? 542 VAL   A HG22 1 
ATOM   2617 H HG23 . VAL   A 1 180 ? 2.65787   4.44336   17.27991  1.000 39.94850  ? 542 VAL   A HG23 1 
ATOM   2618 N N    . VAL   A 1 181 ? 2.48263   6.09373   13.99418  1.000 37.67333  ? 543 VAL   A N    1 
ATOM   2619 C CA   . VAL   A 1 181 ? 3.02131   5.36294   12.85320  1.000 38.26130  ? 543 VAL   A CA   1 
ATOM   2620 C C    . VAL   A 1 181 ? 4.22633   4.56380   13.31583  1.000 36.57309  ? 543 VAL   A C    1 
ATOM   2621 O O    . VAL   A 1 181 ? 5.17063   5.10929   13.89086  1.000 40.43876  ? 543 VAL   A O    1 
ATOM   2622 C CB   . VAL   A 1 181 ? 3.38649   6.31590   11.70622  1.000 50.60308  ? 543 VAL   A CB   1 
ATOM   2623 C CG1  . VAL   A 1 181 ? 4.36975   5.65043   10.73042  1.000 52.66724  ? 543 VAL   A CG1  1 
ATOM   2624 C CG2  . VAL   A 1 181 ? 2.10533   6.77264   10.96494  1.000 45.21846  ? 543 VAL   A CG2  1 
ATOM   2625 H H    . VAL   A 1 181 ? 2.72887   6.91633   14.04211  1.000 45.22005  ? 543 VAL   A H    1 
ATOM   2626 H HA   . VAL   A 1 181 ? 2.34928   4.74708   12.52156  1.000 45.92562  ? 543 VAL   A HA   1 
ATOM   2627 H HB   . VAL   A 1 181 ? 3.82405   7.09834   12.07667  1.000 60.73575  ? 543 VAL   A HB   1 
ATOM   2628 H HG11 . VAL   A 1 181 ? 4.35345   6.13171   9.88840   1.000 63.21274  ? 543 VAL   A HG11 1 
ATOM   2629 H HG12 . VAL   A 1 181 ? 5.26139   5.68018   11.11122  1.000 63.21274  ? 543 VAL   A HG12 1 
ATOM   2630 H HG13 . VAL   A 1 181 ? 4.10057   4.72915   10.59010  1.000 63.21274  ? 543 VAL   A HG13 1 
ATOM   2631 H HG21 . VAL   A 1 181 ? 2.35102   7.39938   10.26656  1.000 54.27420  ? 543 VAL   A HG21 1 
ATOM   2632 H HG22 . VAL   A 1 181 ? 1.67211   5.99689   10.57578  1.000 54.27420  ? 543 VAL   A HG22 1 
ATOM   2633 H HG23 . VAL   A 1 181 ? 1.50928   7.20098   11.59909  1.000 54.27420  ? 543 VAL   A HG23 1 
ATOM   2634 N N    . ILE   A 1 182 ? 4.20607   3.27202   13.04235  1.000 42.49659  ? 544 ILE   A N    1 
ATOM   2635 C CA   . ILE   A 1 182 ? 5.29534   2.39028   13.41709  1.000 38.01679  ? 544 ILE   A CA   1 
ATOM   2636 C C    . ILE   A 1 182 ? 6.30235   2.37984   12.27991  1.000 43.46973  ? 544 ILE   A C    1 
ATOM   2637 O O    . ILE   A 1 182 ? 5.95608   2.10477   11.12628  1.000 44.27995  ? 544 ILE   A O    1 
ATOM   2638 C CB   . ILE   A 1 182 ? 4.77260   0.98895   13.74135  1.000 35.84162  ? 544 ILE   A CB   1 
ATOM   2639 C CG1  . ILE   A 1 182 ? 3.61722   1.10416   14.75546  1.000 32.41973  ? 544 ILE   A CG1  1 
ATOM   2640 C CG2  . ILE   A 1 182 ? 5.89460   0.10452   14.24962  1.000 39.93592  ? 544 ILE   A CG2  1 
ATOM   2641 C CD1  . ILE   A 1 182 ? 3.89042   1.94452   15.97917  1.000 36.24678  ? 544 ILE   A CD1  1 
ATOM   2642 H H    . ILE   A 1 182 ? 3.56163   2.87550   12.63360  1.000 51.00796  ? 544 ILE   A H    1 
ATOM   2643 H HA   . ILE   A 1 182 ? 5.74532   2.72802   14.20725  1.000 45.63220  ? 544 ILE   A HA   1 
ATOM   2644 H HB   . ILE   A 1 182 ? 4.43023   0.57222   12.93511  1.000 43.02200  ? 544 ILE   A HB   1 
ATOM   2645 H HG12 . ILE   A 1 182 ? 2.85480   1.49736   14.30267  1.000 38.91573  ? 544 ILE   A HG12 1 
ATOM   2646 H HG13 . ILE   A 1 182 ? 3.39549   0.21192   15.06471  1.000 38.91573  ? 544 ILE   A HG13 1 
ATOM   2647 H HG21 . ILE   A 1 182 ? 5.52089   -0.73917  14.54867  1.000 47.93516  ? 544 ILE   A HG21 1 
ATOM   2648 H HG22 . ILE   A 1 182 ? 6.52581   -0.05002  13.52949  1.000 47.93516  ? 544 ILE   A HG22 1 
ATOM   2649 H HG23 . ILE   A 1 182 ? 6.33810   0.55019   14.98826  1.000 47.93516  ? 544 ILE   A HG23 1 
ATOM   2650 H HD11 . ILE   A 1 182 ? 3.22800   1.73942   16.65743  1.000 43.50820  ? 544 ILE   A HD11 1 
ATOM   2651 H HD12 . ILE   A 1 182 ? 4.77840   1.73939   16.31132  1.000 43.50820  ? 544 ILE   A HD12 1 
ATOM   2652 H HD13 . ILE   A 1 182 ? 3.83634   2.88220   15.73684  1.000 43.50820  ? 544 ILE   A HD13 1 
ATOM   2653 N N    . ASN   A 1 183 ? 7.54438   2.71879   12.61067  1.000 41.06658  ? 545 ASN   A N    1 
ATOM   2654 C CA   . ASN   A 1 183 ? 8.63989   2.80475   11.65778  1.000 45.39282  ? 545 ASN   A CA   1 
ATOM   2655 C C    . ASN   A 1 183 ? 9.93174   2.53039   12.42626  1.000 47.21601  ? 545 ASN   A C    1 
ATOM   2656 O O    . ASN   A 1 183 ? 9.91082   2.08903   13.57538  1.000 38.46323  ? 545 ASN   A O    1 
ATOM   2657 C CB   . ASN   A 1 183 ? 8.62105   4.16850   10.94246  1.000 44.32258  ? 545 ASN   A CB   1 
ATOM   2658 C CG   . ASN   A 1 183 ? 8.97072   5.35362   11.86479  1.000 47.26284  ? 545 ASN   A CG   1 
ATOM   2659 O OD1  . ASN   A 1 183 ? 9.81112   5.26841   12.75408  1.000 45.93868  ? 545 ASN   A OD1  1 
ATOM   2660 N ND2  . ASN   A 1 183 ? 8.33067   6.48015   11.61909  1.000 58.85166  ? 545 ASN   A ND2  1 
ATOM   2661 H H    . ASN   A 1 183 ? 7.78527   2.91096   13.41357  1.000 49.29195  ? 545 ASN   A H    1 
ATOM   2662 H HA   . ASN   A 1 183 ? 8.54533   2.12112   10.97615  1.000 54.48344  ? 545 ASN   A HA   1 
ATOM   2663 H HB2  . ASN   A 1 183 ? 9.26966   4.15263   10.22138  1.000 53.19915  ? 545 ASN   A HB2  1 
ATOM   2664 H HB3  . ASN   A 1 183 ? 7.73223   4.32258   10.58587  1.000 53.19915  ? 545 ASN   A HB3  1 
ATOM   2665 H HD21 . ASN   A 1 183 ? 7.75973   6.51913   10.97714  1.000 70.63405  ? 545 ASN   A HD21 1 
ATOM   2666 H HD22 . ASN   A 1 183 ? 8.48422   7.17582   12.10082  1.000 70.63405  ? 545 ASN   A HD22 1 
ATOM   2667 N N    . SER   A 1 184 ? 11.06140  2.86402   11.80257  1.000 48.23518  ? 546 SER   A N    1 
ATOM   2668 C CA   . SER   A 1 184 ? 12.35103  2.55367   12.40747  1.000 48.95215  ? 546 SER   A CA   1 
ATOM   2669 C C    . SER   A 1 184 ? 12.61984  3.37639   13.66180  1.000 40.85772  ? 546 SER   A C    1 
ATOM   2670 O O    . SER   A 1 184 ? 13.37261  2.92032   14.53108  1.000 45.84356  ? 546 SER   A O    1 
ATOM   2671 C CB   . SER   A 1 184 ? 13.46248  2.76519   11.38270  1.000 55.20757  ? 546 SER   A CB   1 
ATOM   2672 O OG   . SER   A 1 184 ? 13.71823  1.54023   10.71490  1.000 68.99520  ? 546 SER   A OG   1 
ATOM   2673 H H    . SER   A 1 184 ? 11.10587  3.26336   11.04220  1.000 57.89427  ? 546 SER   A H    1 
ATOM   2674 H HA   . SER   A 1 184 ? 12.36036  1.61989   12.66990  1.000 58.75463  ? 546 SER   A HA   1 
ATOM   2675 H HB2  . SER   A 1 184 ? 13.18286  3.43253   10.73665  1.000 66.26114  ? 546 SER   A HB2  1 
ATOM   2676 H HB3  . SER   A 1 184 ? 14.26776  3.05954   11.83633  1.000 66.26114  ? 546 SER   A HB3  1 
ATOM   2677 H HG   . SER   A 1 184 ? 14.33134  1.64349   10.15007  1.000 82.80629  ? 546 SER   A HG   1 
ATOM   2678 N N    . ASN   A 1 185 ? 11.99672  4.54924   13.80665  1.000 37.00190  ? 547 ASN   A N    1 
ATOM   2679 C CA   . ASN   A 1 185 ? 12.20902  5.35277   15.00261  1.000 36.71043  ? 547 ASN   A CA   1 
ATOM   2680 C C    . ASN   A 1 185 ? 11.15789  5.15631   16.07937  1.000 37.87398  ? 547 ASN   A C    1 
ATOM   2681 O O    . ASN   A 1 185 ? 11.41041  5.52621   17.22759  1.000 39.65160  ? 547 ASN   A O    1 
ATOM   2682 C CB   . ASN   A 1 185 ? 12.25715  6.84357   14.65448  1.000 39.99844  ? 547 ASN   A CB   1 
ATOM   2683 C CG   . ASN   A 1 185 ? 13.62373  7.46196   14.93167  1.000 51.63298  ? 547 ASN   A CG   1 
ATOM   2684 O OD1  . ASN   A 1 185 ? 14.20395  7.29917   16.02060  1.000 51.36473  ? 547 ASN   A OD1  1 
ATOM   2685 N ND2  . ASN   A 1 185 ? 14.14932  8.17312   13.94521  1.000 61.55841  ? 547 ASN   A ND2  1 
ATOM   2686 H H    . ASN   A 1 185 ? 11.45555  4.89183   13.23274  1.000 44.41434  ? 547 ASN   A H    1 
ATOM   2687 H HA   . ASN   A 1 185 ? 13.06784  5.09570   15.37309  1.000 44.06457  ? 547 ASN   A HA   1 
ATOM   2688 H HB2  . ASN   A 1 185 ? 12.06141  6.95567   13.71107  1.000 48.01018  ? 547 ASN   A HB2  1 
ATOM   2689 H HB3  . ASN   A 1 185 ? 11.59894  7.31554   15.18824  1.000 48.01018  ? 547 ASN   A HB3  1 
ATOM   2690 H HD21 . ASN   A 1 185 ? 13.72164  8.26278   13.20450  1.000 73.88215  ? 547 ASN   A HD21 1 
ATOM   2691 H HD22 . ASN   A 1 185 ? 14.91818  8.54512   14.04555  1.000 73.88215  ? 547 ASN   A HD22 1 
ATOM   2692 N N    . ILE   A 1 186 ? 9.98812   4.61659   15.74010  1.000 35.60849  ? 548 ILE   A N    1 
ATOM   2693 C CA   . ILE   A 1 186 ? 8.92360   4.35820   16.70580  1.000 34.32233  ? 548 ILE   A CA   1 
ATOM   2694 C C    . ILE   A 1 186 ? 8.44490   2.93142   16.48603  1.000 35.48570  ? 548 ILE   A C    1 
ATOM   2695 O O    . ILE   A 1 186 ? 7.91688   2.61578   15.41727  1.000 31.07655  ? 548 ILE   A O    1 
ATOM   2696 C CB   . ILE   A 1 186 ? 7.74415   5.33175   16.57610  1.000 29.18411  ? 548 ILE   A CB   1 
ATOM   2697 C CG1  . ILE   A 1 186 ? 8.19095   6.76404   16.82918  1.000 30.05470  ? 548 ILE   A CG1  1 
ATOM   2698 C CG2  . ILE   A 1 186 ? 6.66856   4.97096   17.56957  1.000 29.30914  ? 548 ILE   A CG2  1 
ATOM   2699 C CD1  . ILE   A 1 186 ? 7.19140   7.80474   16.36445  1.000 31.30936  ? 548 ILE   A CD1  1 
ATOM   2700 H H    . ILE   A 1 186 ? 9.78396   4.38653   14.93699  1.000 42.74224  ? 548 ILE   A H    1 
ATOM   2701 H HA   . ILE   A 1 186 ? 9.28657   4.44550   17.60109  1.000 41.19885  ? 548 ILE   A HA   1 
ATOM   2702 H HB   . ILE   A 1 186 ? 7.40024   5.26316   15.67171  1.000 35.03299  ? 548 ILE   A HB   1 
ATOM   2703 H HG12 . ILE   A 1 186 ? 8.32406   6.88576   17.78226  1.000 36.07770  ? 548 ILE   A HG12 1 
ATOM   2704 H HG13 . ILE   A 1 186 ? 9.02294   6.91985   16.35544  1.000 36.07770  ? 548 ILE   A HG13 1 
ATOM   2705 H HG21 . ILE   A 1 186 ? 6.07072   5.72733   17.67635  1.000 35.18303  ? 548 ILE   A HG21 1 
ATOM   2706 H HG22 . ILE   A 1 186 ? 6.17594   4.20432   17.23718  1.000 35.18303  ? 548 ILE   A HG22 1 
ATOM   2707 H HG23 . ILE   A 1 186 ? 7.08326   4.75458   18.41933  1.000 35.18303  ? 548 ILE   A HG23 1 
ATOM   2708 H HD11 . ILE   A 1 186 ? 7.60807   8.68004   16.39823  1.000 37.58328  ? 548 ILE   A HD11 1 
ATOM   2709 H HD12 . ILE   A 1 186 ? 6.92320   7.60095   15.45481  1.000 37.58328  ? 548 ILE   A HD12 1 
ATOM   2710 H HD13 . ILE   A 1 186 ? 6.41826   7.78361   16.94986  1.000 37.58328  ? 548 ILE   A HD13 1 
ATOM   2711 N N    . THR   A 1 187 ? 8.61353   2.08600   17.50648  1.000 32.24033  ? 549 THR   A N    1 
ATOM   2712 C CA   . THR   A 1 187 ? 8.36225   0.66648   17.45868  1.000 33.54730  ? 549 THR   A CA   1 
ATOM   2713 C C    . THR   A 1 187 ? 8.03651   0.31190   18.90675  1.000 32.66643  ? 549 THR   A C    1 
ATOM   2714 O O    . THR   A 1 187 ? 8.78582   0.70253   19.80043  1.000 27.81311  ? 549 THR   A O    1 
ATOM   2715 C CB   . THR   A 1 187 ? 9.55352   -0.16329  16.96530  1.000 37.23266  ? 549 THR   A CB   1 
ATOM   2716 O OG1  . THR   A 1 187 ? 9.83318   0.16617   15.59937  1.000 44.20399  ? 549 THR   A OG1  1 
ATOM   2717 C CG2  . THR   A 1 187 ? 9.28293   -1.67590  17.07046  1.000 40.21249  ? 549 THR   A CG2  1 
ATOM   2718 H H    . THR   A 1 187 ? 8.89046   2.33752   18.28085  1.000 38.70045  ? 549 THR   A H    1 
ATOM   2719 H HA   . THR   A 1 187 ? 7.63130   0.46377   16.85409  1.000 40.26882  ? 549 THR   A HA   1 
ATOM   2720 H HB   . THR   A 1 187 ? 10.32103  0.03808   17.52322  1.000 44.69125  ? 549 THR   A HB   1 
ATOM   2721 H HG1  . THR   A 1 187 ? 10.51359  -0.25060  15.33682  1.000 53.05684  ? 549 THR   A HG1  1 
ATOM   2722 H HG21 . THR   A 1 187 ? 10.01297  -2.17226  16.66852  1.000 48.26705  ? 549 THR   A HG21 1 
ATOM   2723 H HG22 . THR   A 1 187 ? 9.20168   -1.93443  18.00184  1.000 48.26705  ? 549 THR   A HG22 1 
ATOM   2724 H HG23 . THR   A 1 187 ? 8.45927   -1.89846  16.60898  1.000 48.26705  ? 549 THR   A HG23 1 
ATOM   2725 N N    . PRO   A 1 188 ? 6.95882   -0.40534  19.17367  1.000 27.55848  ? 550 PRO   A N    1 
ATOM   2726 C CA   . PRO   A 1 188 ? 6.67111   -0.78212  20.56145  1.000 25.44305  ? 550 PRO   A CA   1 
ATOM   2727 C C    . PRO   A 1 188 ? 7.65575   -1.79915  21.09791  1.000 28.14825  ? 550 PRO   A C    1 
ATOM   2728 O O    . PRO   A 1 188 ? 8.40714   -2.45272  20.36790  1.000 26.66697  ? 550 PRO   A O    1 
ATOM   2729 C CB   . PRO   A 1 188 ? 5.27668   -1.39929  20.47448  1.000 25.38304  ? 550 PRO   A CB   1 
ATOM   2730 C CG   . PRO   A 1 188 ? 5.26167   -1.99406  19.12481  1.000 29.22339  ? 550 PRO   A CG   1 
ATOM   2731 C CD   . PRO   A 1 188 ? 5.96614   -0.98615  18.25090  1.000 27.76351  ? 550 PRO   A CD   1 
ATOM   2732 H HA   . PRO   A 1 188 ? 6.66808   0.00521   21.12802  1.000 30.54371  ? 550 PRO   A HA   1 
ATOM   2733 H HB2  . PRO   A 1 188 ? 5.16233   -2.07500  21.16094  1.000 30.47170  ? 550 PRO   A HB2  1 
ATOM   2734 H HB3  . PRO   A 1 188 ? 4.59683   -0.71366  20.56732  1.000 30.47170  ? 550 PRO   A HB3  1 
ATOM   2735 H HG2  . PRO   A 1 188 ? 5.73567   -2.84034  19.13039  1.000 35.08012  ? 550 PRO   A HG2  1 
ATOM   2736 H HG3  . PRO   A 1 188 ? 4.34669   -2.12821  18.83202  1.000 35.08012  ? 550 PRO   A HG3  1 
ATOM   2737 H HD2  . PRO   A 1 188 ? 6.40038   -1.41944  17.49950  1.000 33.32826  ? 550 PRO   A HD2  1 
ATOM   2738 H HD3  . PRO   A 1 188 ? 5.34875   -0.30933  17.93209  1.000 33.32826  ? 550 PRO   A HD3  1 
ATOM   2739 N N    . ILE   A 1 189 ? 7.65361   -1.91136  22.40777  1.000 27.12879  ? 551 ILE   A N    1 
ATOM   2740 C CA   . ILE   A 1 189 ? 8.35337   -2.97077  23.11731  1.000 28.12584  ? 551 ILE   A CA   1 
ATOM   2741 C C    . ILE   A 1 189 ? 7.43773   -4.19738  23.18100  1.000 24.69959  ? 551 ILE   A C    1 
ATOM   2742 O O    . ILE   A 1 189 ? 6.21388   -4.07840  23.22513  1.000 27.12043  ? 551 ILE   A O    1 
ATOM   2743 C CB   . ILE   A 1 189 ? 8.77836   -2.49179  24.52259  1.000 22.92654  ? 551 ILE   A CB   1 
ATOM   2744 C CG1  . ILE   A 1 189 ? 9.65722   -3.54436  25.22717  1.000 24.43951  ? 551 ILE   A CG1  1 
ATOM   2745 C CG2  . ILE   A 1 189 ? 7.55384   -2.17101  25.41000  1.000 24.05674  ? 551 ILE   A CG2  1 
ATOM   2746 C CD1  . ILE   A 1 189 ? 10.99677  -3.71905  24.63872  1.000 23.35492  ? 551 ILE   A CD1  1 
ATOM   2747 H H    . ILE   A 1 189 ? 7.24042   -1.36878  22.93169  1.000 32.56660  ? 551 ILE   A H    1 
ATOM   2748 H HA   . ILE   A 1 189 ? 9.15603   -3.21824  22.63213  1.000 33.76306  ? 551 ILE   A HA   1 
ATOM   2749 H HB   . ILE   A 1 189 ? 9.29333   -1.67985  24.39427  1.000 27.52390  ? 551 ILE   A HB   1 
ATOM   2750 H HG12 . ILE   A 1 189 ? 9.77674   -3.27737  26.15201  1.000 29.33946  ? 551 ILE   A HG12 1 
ATOM   2751 H HG13 . ILE   A 1 189 ? 9.20538   -4.40167  25.18510  1.000 29.33946  ? 551 ILE   A HG13 1 
ATOM   2752 H HG21 . ILE   A 1 189 ? 7.86062   -1.77209  26.23925  1.000 28.88015  ? 551 ILE   A HG21 1 
ATOM   2753 H HG22 . ILE   A 1 189 ? 6.97594   -1.55083  24.93852  1.000 28.88015  ? 551 ILE   A HG22 1 
ATOM   2754 H HG23 . ILE   A 1 189 ? 7.07454   -2.99353  25.59608  1.000 28.88015  ? 551 ILE   A HG23 1 
ATOM   2755 H HD11 . ILE   A 1 189 ? 11.51461  -4.31395  25.20337  1.000 28.03796  ? 551 ILE   A HD11 1 
ATOM   2756 H HD12 . ILE   A 1 189 ? 10.90477  -4.10140  23.75201  1.000 28.03796  ? 551 ILE   A HD12 1 
ATOM   2757 H HD13 . ILE   A 1 189 ? 11.43221  -2.85411  24.58242  1.000 28.03796  ? 551 ILE   A HD13 1 
ATOM   2758 N N    . CYS   A 1 190 ? 8.02693   -5.38661  23.19884  1.000 25.35964  ? 552 CYS   A N    1 
ATOM   2759 C CA   . CYS   A 1 190 ? 7.24190   -6.60612  23.36533  1.000 18.24859  ? 552 CYS   A CA   1 
ATOM   2760 C C    . CYS   A 1 190 ? 6.93083   -6.85267  24.84232  1.000 24.07955  ? 552 CYS   A C    1 
ATOM   2761 O O    . CYS   A 1 190 ? 7.68355   -6.49707  25.73758  1.000 26.86569  ? 552 CYS   A O    1 
ATOM   2762 C CB   . CYS   A 1 190 ? 7.95217   -7.85341  22.82347  1.000 21.61013  ? 552 CYS   A CB   1 
ATOM   2763 S SG   . CYS   A 1 190 ? 8.50036   -7.77804  21.14229  1.000 27.80036  ? 552 CYS   A SG   1 
ATOM   2764 H H    . CYS   A 1 190 ? 8.87337   -5.51501  23.11727  1.000 30.44362  ? 552 CYS   A H    1 
ATOM   2765 H HA   . CYS   A 1 190 ? 6.42207   -6.48559  22.86108  1.000 21.91036  ? 552 CYS   A HA   1 
ATOM   2766 H HB2  . CYS   A 1 190 ? 8.73566   -8.01625  23.37167  1.000 25.94421  ? 552 CYS   A HB2  1 
ATOM   2767 H HB3  . CYS   A 1 190 ? 7.33920   -8.60223  22.89005  1.000 25.94421  ? 552 CYS   A HB3  1 
ATOM   2768 N N    . LEU   A 1 191 ? 5.76435   -7.41129  25.07427  1.000 24.09202  ? 553 LEU   A N    1 
ATOM   2769 C CA   . LEU   A 1 191 ? 5.40574   -7.95482  26.37393  1.000 27.96563  ? 553 LEU   A CA   1 
ATOM   2770 C C    . LEU   A 1 191 ? 6.13359   -9.27836  26.58570  1.000 24.46193  ? 553 LEU   A C    1 
ATOM   2771 O O    . LEU   A 1 191 ? 6.43947   -9.98584  25.62193  1.000 23.30257  ? 553 LEU   A O    1 
ATOM   2772 C CB   . LEU   A 1 191 ? 3.88492   -8.19013  26.44695  1.000 32.76229  ? 553 LEU   A CB   1 
ATOM   2773 C CG   . LEU   A 1 191 ? 3.09000   -6.87240  26.51965  1.000 27.72336  ? 553 LEU   A CG   1 
ATOM   2774 C CD1  . LEU   A 1 191 ? 1.60266   -7.10084  26.53908  1.000 32.29669  ? 553 LEU   A CD1  1 
ATOM   2775 C CD2  . LEU   A 1 191 ? 3.54039   -6.07069  27.76945  1.000 23.85779  ? 553 LEU   A CD2  1 
ATOM   2776 H H    . LEU   A 1 191 ? 5.14292   -7.49326  24.48546  1.000 28.92248  ? 553 LEU   A H    1 
ATOM   2777 H HA   . LEU   A 1 191 ? 5.65565   -7.33678  27.07853  1.000 33.57081  ? 553 LEU   A HA   1 
ATOM   2778 H HB2  . LEU   A 1 191 ? 3.60077   -8.67156  25.65425  1.000 39.32680  ? 553 LEU   A HB2  1 
ATOM   2779 H HB3  . LEU   A 1 191 ? 3.68283   -8.70957  27.24083  1.000 39.32680  ? 553 LEU   A HB3  1 
ATOM   2780 H HG   . LEU   A 1 191 ? 3.27343   -6.35464  25.72016  1.000 33.28009  ? 553 LEU   A HG   1 
ATOM   2781 H HD11 . LEU   A 1 191 ? 1.15165   -6.24249  26.56603  1.000 38.76808  ? 553 LEU   A HD11 1 
ATOM   2782 H HD12 . LEU   A 1 191 ? 1.34685   -7.58389  25.73775  1.000 38.76808  ? 553 LEU   A HD12 1 
ATOM   2783 H HD13 . LEU   A 1 191 ? 1.37313   -7.61995  27.32568  1.000 38.76808  ? 553 LEU   A HD13 1 
ATOM   2784 H HD21 . LEU   A 1 191 ? 2.82896   -5.46461  28.02912  1.000 28.64140  ? 553 LEU   A HD21 1 
ATOM   2785 H HD22 . LEU   A 1 191 ? 3.72702   -6.69052  28.49187  1.000 28.64140  ? 553 LEU   A HD22 1 
ATOM   2786 H HD23 . LEU   A 1 191 ? 4.34019   -5.56743  27.55047  1.000 28.64140  ? 553 LEU   A HD23 1 
ATOM   2787 N N    . PRO   A 1 192 ? 6.48198   -9.61403  27.82525  1.000 26.88444  ? 554 PRO   A N    1 
ATOM   2788 C CA   . PRO   A 1 192 ? 7.19559   -10.87718 28.03114  1.000 29.66944  ? 554 PRO   A CA   1 
ATOM   2789 C C    . PRO   A 1 192 ? 6.31873   -12.08071 27.71278  1.000 33.38372  ? 554 PRO   A C    1 
ATOM   2790 O O    . PRO   A 1 192 ? 5.14849   -12.13270 28.08092  1.000 32.72201  ? 554 PRO   A O    1 
ATOM   2791 C CB   . PRO   A 1 192 ? 7.56768   -10.84527 29.51745  1.000 29.29202  ? 554 PRO   A CB   1 
ATOM   2792 C CG   . PRO   A 1 192 ? 6.61761   -9.87698  30.14227  1.000 30.38003  ? 554 PRO   A CG   1 
ATOM   2793 C CD   . PRO   A 1 192 ? 6.37308   -8.84751  29.08584  1.000 29.14452  ? 554 PRO   A CD   1 
ATOM   2794 H HA   . PRO   A 1 192 ? 7.99865   -10.90289 27.48768  1.000 35.61538  ? 554 PRO   A HA   1 
ATOM   2795 H HB2  . PRO   A 1 192 ? 7.46261   -11.72971 29.90165  1.000 35.16248  ? 554 PRO   A HB2  1 
ATOM   2796 H HB3  . PRO   A 1 192 ? 8.48447   -10.54560 29.62041  1.000 35.16248  ? 554 PRO   A HB3  1 
ATOM   2797 H HG2  . PRO   A 1 192 ? 5.79427   -10.32932 30.38392  1.000 36.46809  ? 554 PRO   A HG2  1 
ATOM   2798 H HG3  . PRO   A 1 192 ? 7.02044   -9.47824  30.92945  1.000 36.46809  ? 554 PRO   A HG3  1 
ATOM   2799 H HD2  . PRO   A 1 192 ? 5.48798   -8.46175  29.17907  1.000 34.98548  ? 554 PRO   A HD2  1 
ATOM   2800 H HD3  . PRO   A 1 192 ? 7.04506   -8.14900  29.12341  1.000 34.98548  ? 554 PRO   A HD3  1 
ATOM   2801 N N    . ARG   A 1 193 ? 6.89601   -13.05860 27.03012  1.000 34.60897  ? 555 ARG   A N    1 
ATOM   2802 C CA   . ARG   A 1 193 ? 6.25073   -14.37032 27.01422  1.000 32.65246  ? 555 ARG   A CA   1 
ATOM   2803 C C    . ARG   A 1 193 ? 6.38336   -15.04627 28.37975  1.000 33.54523  ? 555 ARG   A C    1 
ATOM   2804 O O    . ARG   A 1 193 ? 7.19048   -14.64759 29.21663  1.000 31.32570  ? 555 ARG   A O    1 
ATOM   2805 C CB   . ARG   A 1 193 ? 6.83029   -15.24944 25.91570  1.000 31.31461  ? 555 ARG   A CB   1 
ATOM   2806 C CG   . ARG   A 1 193 ? 8.30616   -15.40202 25.82277  1.000 35.26215  ? 555 ARG   A CG   1 
ATOM   2807 C CD   . ARG   A 1 193 ? 8.59846   -16.19710 24.52426  1.000 39.27570  ? 555 ARG   A CD   1 
ATOM   2808 N NE   . ARG   A 1 193 ? 10.02494  -16.35834 24.27357  1.000 42.13852  ? 555 ARG   A NE   1 
ATOM   2809 C CZ   . ARG   A 1 193 ? 10.65160  -17.49396 23.96654  1.000 41.30273  ? 555 ARG   A CZ   1 
ATOM   2810 N NH1  . ARG   A 1 193 ? 9.99559   -18.62101 23.72002  1.000 38.30570  ? 555 ARG   A NH1  1 
ATOM   2811 N NH2  . ARG   A 1 193 ? 11.97878  -17.48879 23.87905  1.000 37.52014  ? 555 ARG   A NH2  1 
ATOM   2812 H H    . ARG   A 1 193 ? 7.62955   -12.99522 26.58572  1.000 41.54282  ? 555 ARG   A H    1 
ATOM   2813 H HA   . ARG   A 1 193 ? 5.30538   -14.26357 26.82497  1.000 39.19500  ? 555 ARG   A HA   1 
ATOM   2814 H HB2  . ARG   A 1 193 ? 6.46949   -16.14187 26.03528  1.000 37.58959  ? 555 ARG   A HB2  1 
ATOM   2815 H HB3  . ARG   A 1 193 ? 6.53839   -14.88475 25.06559  1.000 37.58959  ? 555 ARG   A HB3  1 
ATOM   2816 H HG2  . ARG   A 1 193 ? 8.73368   -14.53273 25.77309  1.000 42.32663  ? 555 ARG   A HG2  1 
ATOM   2817 H HG3  . ARG   A 1 193 ? 8.64412   -15.89475 26.58690  1.000 42.32663  ? 555 ARG   A HG3  1 
ATOM   2818 H HD2  . ARG   A 1 193 ? 8.20504   -17.08062 24.59863  1.000 47.14289  ? 555 ARG   A HD2  1 
ATOM   2819 H HD3  . ARG   A 1 193 ? 8.21271   -15.72459 23.77005  1.000 47.14289  ? 555 ARG   A HD3  1 
ATOM   2820 H HE   . ARG   A 1 193 ? 10.51050  -15.65072 24.32925  1.000 50.57827  ? 555 ARG   A HE   1 
ATOM   2821 H HH11 . ARG   A 1 193 ? 9.13644   -18.63508 23.75570  1.000 45.97889  ? 555 ARG   A HH11 1 
ATOM   2822 H HH12 . ARG   A 1 193 ? 10.42963  -19.33726 23.52461  1.000 45.97889  ? 555 ARG   A HH12 1 
ATOM   2823 H HH21 . ARG   A 1 193 ? 12.41614  -16.76176 24.01957  1.000 45.03622  ? 555 ARG   A HH21 1 
ATOM   2824 H HH22 . ARG   A 1 193 ? 12.39954  -18.21247 23.68196  1.000 45.03622  ? 555 ARG   A HH22 1 
ATOM   2825 N N    . LYS   A 1 194 ? 5.56617   -16.08510 28.59882  1.000 34.25994  ? 556 LYS   A N    1 
ATOM   2826 C CA   . LYS   A 1 194 ? 5.43647   -16.67822 29.92947  1.000 38.01039  ? 556 LYS   A CA   1 
ATOM   2827 C C    . LYS   A 1 194 ? 6.77041   -17.20329 30.44024  1.000 33.76469  ? 556 LYS   A C    1 
ATOM   2828 O O    . LYS   A 1 194 ? 7.09525   -17.05087 31.62068  1.000 46.38120  ? 556 LYS   A O    1 
ATOM   2829 C CB   . LYS   A 1 194 ? 4.39150   -17.81086 29.91182  1.000 40.94835  ? 556 LYS   A CB   1 
ATOM   2830 C CG   . LYS   A 1 194 ? 4.72199   -18.96262 28.97810  1.000 50.48204  ? 556 LYS   A CG   1 
ATOM   2831 C CD   . LYS   A 1 194 ? 3.60129   -20.02511 28.93000  1.000 52.35856  ? 556 LYS   A CD   1 
ATOM   2832 C CE   . LYS   A 1 194 ? 3.13323   -20.27986 27.49761  1.000 56.04883  ? 556 LYS   A CE   1 
ATOM   2833 N NZ   . LYS   A 1 194 ? 1.79746   -20.94087 27.45107  1.000 56.40025  ? 556 LYS   A NZ   1 
ATOM   2834 H H    . LYS   A 1 194 ? 5.08033   -16.46073 27.99678  1.000 41.12398  ? 556 LYS   A H    1 
ATOM   2835 H HA   . LYS   A 1 194 ? 5.12830   -15.99002 30.53965  1.000 45.62452  ? 556 LYS   A HA   1 
ATOM   2836 H HB2  . LYS   A 1 194 ? 4.31488   -18.17378 30.80810  1.000 49.15007  ? 556 LYS   A HB2  1 
ATOM   2837 H HB3  . LYS   A 1 194 ? 3.54034   -17.44083 29.62984  1.000 49.15007  ? 556 LYS   A HB3  1 
ATOM   2838 H HG2  . LYS   A 1 194 ? 4.84773   -18.61747 28.08035  1.000 60.59050  ? 556 LYS   A HG2  1 
ATOM   2839 H HG3  . LYS   A 1 194 ? 5.53420   -19.39602 29.28369  1.000 60.59050  ? 556 LYS   A HG3  1 
ATOM   2840 H HD2  . LYS   A 1 194 ? 3.93391   -20.85991 29.29520  1.000 62.84233  ? 556 LYS   A HD2  1 
ATOM   2841 H HD3  . LYS   A 1 194 ? 2.84219   -19.71531 29.44837  1.000 62.84233  ? 556 LYS   A HD3  1 
ATOM   2842 H HE2  . LYS   A 1 194 ? 3.06798   -19.43334 27.02852  1.000 67.27065  ? 556 LYS   A HE2  1 
ATOM   2843 H HE3  . LYS   A 1 194 ? 3.77207   -20.85781 27.05179  1.000 67.27065  ? 556 LYS   A HE3  1 
ATOM   2844 H HZ1  . LYS   A 1 194 ? 1.62393   -21.21859 26.62351  1.000 67.69235  ? 556 LYS   A HZ1  1 
ATOM   2845 H HZ2  . LYS   A 1 194 ? 1.78539   -21.64176 27.99944  1.000 67.69235  ? 556 LYS   A HZ2  1 
ATOM   2846 H HZ3  . LYS   A 1 194 ? 1.16499   -20.36708 27.70176  1.000 67.69235  ? 556 LYS   A HZ3  1 
ATOM   2847 N N    . GLU   A 1 195 ? 7.57415   -17.79233 29.56080  1.000 32.58051  ? 557 GLU   A N    1 
ATOM   2848 C CA   . GLU   A 1 195 ? 8.86476   -18.32538 29.96116  1.000 39.17891  ? 557 GLU   A CA   1 
ATOM   2849 C C    . GLU   A 1 195 ? 9.94791   -17.25896 30.03320  1.000 38.70908  ? 557 GLU   A C    1 
ATOM   2850 O O    . GLU   A 1 195 ? 11.09707  -17.59295 30.35002  1.000 37.18972  ? 557 GLU   A O    1 
ATOM   2851 C CB   . GLU   A 1 195 ? 9.26492   -19.46410 29.00923  1.000 39.62881  ? 557 GLU   A CB   1 
ATOM   2852 C CG   . GLU   A 1 195 ? 9.51619   -19.06110 27.56416  1.000 39.63674  ? 557 GLU   A CG   1 
ATOM   2853 C CD   . GLU   A 1 195 ? 8.30362   -19.25688 26.69137  1.000 43.74752  ? 557 GLU   A CD   1 
ATOM   2854 O OE1  . GLU   A 1 195 ? 7.22999   -18.71363 27.03714  1.000 43.55916  ? 557 GLU   A OE1  1 
ATOM   2855 O OE2  . GLU   A 1 195 ? 8.41928   -19.95031 25.66559  1.000 47.41414  ? 557 GLU   A OE2  1 
ATOM   2856 H H    . GLU   A 1 195 ? 7.39186   -17.89417 28.72654  1.000 39.10867  ? 557 GLU   A H    1 
ATOM   2857 H HA   . GLU   A 1 195 ? 8.79729   -18.70766 30.85009  1.000 47.02675  ? 557 GLU   A HA   1 
ATOM   2858 H HB2  . GLU   A 1 195 ? 10.08296  -19.86519 29.34217  1.000 47.56662  ? 557 GLU   A HB2  1 
ATOM   2859 H HB3  . GLU   A 1 195 ? 8.55133   -20.12112 29.00448  1.000 47.56662  ? 557 GLU   A HB3  1 
ATOM   2860 H HG2  . GLU   A 1 195 ? 9.75998   -18.12270 27.53454  1.000 47.57614  ? 557 GLU   A HG2  1 
ATOM   2861 H HG3  . GLU   A 1 195 ? 10.23633  -19.60246 27.20469  1.000 47.57614  ? 557 GLU   A HG3  1 
ATOM   2862 N N    . ALA   A 1 196 ? 9.59730   -15.98964 29.80426  1.000 36.77234  ? 558 ALA   A N    1 
ATOM   2863 C CA   . ALA   A 1 196 ? 10.59129  -14.92355 29.76855  1.000 35.94851  ? 558 ALA   A CA   1 
ATOM   2864 C C    . ALA   A 1 196 ? 11.29775  -14.74157 31.10008  1.000 31.14170  ? 558 ALA   A C    1 
ATOM   2865 O O    . ALA   A 1 196 ? 12.35476  -14.11113 31.13587  1.000 31.04378  ? 558 ALA   A O    1 
ATOM   2866 C CB   . ALA   A 1 196 ? 9.92373   -13.60903 29.35314  1.000 33.19038  ? 558 ALA   A CB   1 
ATOM   2867 H H    . ALA   A 1 196 ? 8.79118   -15.72322 29.66719  1.000 44.13887  ? 558 ALA   A H    1 
ATOM   2868 H HA   . ALA   A 1 196 ? 11.26391  -15.14967 29.10722  1.000 43.15027  ? 558 ALA   A HA   1 
ATOM   2869 H HB1  . ALA   A 1 196 ? 10.59711  -12.91204 29.31214  1.000 39.84051  ? 558 ALA   A HB1  1 
ATOM   2870 H HB2  . ALA   A 1 196 ? 9.51382   -13.72462 28.48164  1.000 39.84051  ? 558 ALA   A HB2  1 
ATOM   2871 H HB3  . ALA   A 1 196 ? 9.24737   -13.37736 30.00870  1.000 39.84051  ? 558 ALA   A HB3  1 
ATOM   2872 N N    . GLU   A 1 197 ? 10.73349  -15.26308 32.19571  1.000 34.33061  ? 559 GLU   A N    1 
ATOM   2873 C CA   . GLU   A 1 197 ? 11.43288  -15.27328 33.47570  1.000 37.48976  ? 559 GLU   A CA   1 
ATOM   2874 C C    . GLU   A 1 197 ? 12.85297  -15.81091 33.36575  1.000 37.08598  ? 559 GLU   A C    1 
ATOM   2875 O O    . GLU   A 1 197 ? 13.74100  -15.35074 34.09126  1.000 36.83133  ? 559 GLU   A O    1 
ATOM   2876 C CB   . GLU   A 1 197 ? 10.68023  -16.13302 34.49466  1.000 48.62666  ? 559 GLU   A CB   1 
ATOM   2877 C CG   . GLU   A 1 197 ? 9.36143   -15.56682 34.93246  1.000 57.14667  ? 559 GLU   A CG   1 
ATOM   2878 C CD   . GLU   A 1 197 ? 9.45462   -14.74328 36.20903  1.000 61.46551  ? 559 GLU   A CD   1 
ATOM   2879 O OE1  . GLU   A 1 197 ? 10.37310  -13.89195 36.31503  1.000 57.55754  ? 559 GLU   A OE1  1 
ATOM   2880 O OE2  . GLU   A 1 197 ? 8.58996   -14.93843 37.10095  1.000 56.85526  ? 559 GLU   A OE2  1 
ATOM   2881 H H    . GLU   A 1 197 ? 9.94926   -15.61514 32.22086  1.000 41.20879  ? 559 GLU   A H    1 
ATOM   2882 H HA   . GLU   A 1 197 ? 11.46557  -14.35489 33.78616  1.000 44.99977  ? 559 GLU   A HA   1 
ATOM   2883 H HB2  . GLU   A 1 197 ? 10.50928  -17.00215 34.09932  1.000 58.36405  ? 559 GLU   A HB2  1 
ATOM   2884 H HB3  . GLU   A 1 197 ? 11.23390  -16.23119 35.28505  1.000 58.36405  ? 559 GLU   A HB3  1 
ATOM   2885 H HG2  . GLU   A 1 197 ? 9.01836   -14.99118 34.23115  1.000 68.58806  ? 559 GLU   A HG2  1 
ATOM   2886 H HG3  . GLU   A 1 197 ? 8.74397   -16.29731 35.09379  1.000 68.58806  ? 559 GLU   A HG3  1 
ATOM   2887 N N    . SER   A 1 198 ? 13.09049  -16.77803 32.46639  1.000 30.83638  ? 560 SER   A N    1 
ATOM   2888 C CA   . SER   A 1 198 ? 14.43966  -17.33072 32.31414  1.000 33.00353  ? 560 SER   A CA   1 
ATOM   2889 C C    . SER   A 1 198 ? 15.45470  -16.27912 31.87389  1.000 35.37435  ? 560 SER   A C    1 
ATOM   2890 O O    . SER   A 1 198 ? 16.66030  -16.51595 31.99557  1.000 32.34566  ? 560 SER   A O    1 
ATOM   2891 C CB   . SER   A 1 198 ? 14.44499  -18.48308 31.30494  1.000 29.03198  ? 560 SER   A CB   1 
ATOM   2892 O OG   . SER   A 1 198 ? 13.68384  -19.57410 31.76885  1.000 31.11487  ? 560 SER   A OG   1 
ATOM   2893 H H    . SER   A 1 198 ? 12.49956  -17.12224 31.94493  1.000 37.01571  ? 560 SER   A H    1 
ATOM   2894 H HA   . SER   A 1 198 ? 14.71245  -17.68188 33.17621  1.000 39.61629  ? 560 SER   A HA   1 
ATOM   2895 H HB2  . SER   A 1 198 ? 14.06667  -18.16953 30.46860  1.000 34.85043  ? 560 SER   A HB2  1 
ATOM   2896 H HB3  . SER   A 1 198 ? 15.35968  -18.77482 31.16659  1.000 34.85043  ? 560 SER   A HB3  1 
ATOM   2897 H HG   . SER   A 1 198 ? 12.87380  -19.35789 31.82075  1.000 37.34990  ? 560 SER   A HG   1 
ATOM   2898 N N    . PHE   A 1 199 ? 14.99920  -15.14569 31.32335  1.000 32.55768  ? 561 PHE   A N    1 
ATOM   2899 C CA   . PHE   A 1 199 ? 15.86004  -14.03196 30.96403  1.000 31.85462  ? 561 PHE   A CA   1 
ATOM   2900 C C    . PHE   A 1 199 ? 15.93017  -12.96005 32.03927  1.000 31.79394  ? 561 PHE   A C    1 
ATOM   2901 O O    . PHE   A 1 199 ? 16.61499  -11.94732 31.83968  1.000 29.99048  ? 561 PHE   A O    1 
ATOM   2902 C CB   . PHE   A 1 199 ? 15.36906  -13.37878 29.65955  1.000 28.33389  ? 561 PHE   A CB   1 
ATOM   2903 C CG   . PHE   A 1 199 ? 15.28424  -14.31545 28.51215  1.000 33.74478  ? 561 PHE   A CG   1 
ATOM   2904 C CD1  . PHE   A 1 199 ? 16.43488  -14.88842 27.98356  1.000 35.81563  ? 561 PHE   A CD1  1 
ATOM   2905 C CD2  . PHE   A 1 199 ? 14.05070  -14.64001 27.95340  1.000 34.17861  ? 561 PHE   A CD2  1 
ATOM   2906 C CE1  . PHE   A 1 199 ? 16.35434  -15.76260 26.91524  1.000 39.83945  ? 561 PHE   A CE1  1 
ATOM   2907 C CE2  . PHE   A 1 199 ? 13.97526  -15.50945 26.88321  1.000 29.23688  ? 561 PHE   A CE2  1 
ATOM   2908 C CZ   . PHE   A 1 199 ? 15.12819  -16.06841 26.36759  1.000 31.11563  ? 561 PHE   A CZ   1 
ATOM   2909 H H    . PHE   A 1 199 ? 14.16985  -15.00239 31.14659  1.000 39.08127  ? 561 PHE   A H    1 
ATOM   2910 H HA   . PHE   A 1 199 ? 16.75333  -14.38178 30.82060  1.000 38.23759  ? 561 PHE   A HA   1 
ATOM   2911 H HB2  . PHE   A 1 199 ? 14.48290  -13.01360 29.80874  1.000 34.01272  ? 561 PHE   A HB2  1 
ATOM   2912 H HB3  . PHE   A 1 199 ? 15.98380  -12.66894 29.41642  1.000 34.01272  ? 561 PHE   A HB3  1 
ATOM   2913 H HD1  . PHE   A 1 199 ? 17.26419  -14.68257 28.35068  1.000 42.99081  ? 561 PHE   A HD1  1 
ATOM   2914 H HD2  . PHE   A 1 199 ? 13.27294  -14.26896 28.30311  1.000 41.02638  ? 561 PHE   A HD2  1 
ATOM   2915 H HE1  . PHE   A 1 199 ? 17.12770  -16.14383 26.56671  1.000 47.81940  ? 561 PHE   A HE1  1 
ATOM   2916 H HE2  . PHE   A 1 199 ? 13.14933  -15.71831 26.51022  1.000 35.09631  ? 561 PHE   A HE2  1 
ATOM   2917 H HZ   . PHE   A 1 199 ? 15.07632  -16.65415 25.64709  1.000 37.35081  ? 561 PHE   A HZ   1 
ATOM   2918 N N    . MET   A 1 200 ? 15.22883  -13.14963 33.15548  1.000 33.62553  ? 562 MET   A N    1 
ATOM   2919 C CA   . MET   A 1 200 ? 15.11166  -12.18089 34.23377  1.000 25.98781  ? 562 MET   A CA   1 
ATOM   2920 C C    . MET   A 1 200 ? 15.50693  -12.82504 35.54925  1.000 32.04917  ? 562 MET   A C    1 
ATOM   2921 O O    . MET   A 1 200 ? 14.85948  -12.62319 36.58067  1.000 27.74247  ? 562 MET   A O    1 
ATOM   2922 C CB   . MET   A 1 200 ? 13.68384  -11.63825 34.31107  1.000 29.62842  ? 562 MET   A CB   1 
ATOM   2923 C CG   . MET   A 1 200 ? 13.28188  -10.87484 33.06275  1.000 34.81560  ? 562 MET   A CG   1 
ATOM   2924 S SD   . MET   A 1 200 ? 11.72934  -9.98581  33.23839  1.000 27.06243  ? 562 MET   A SD   1 
ATOM   2925 C CE   . MET   A 1 200 ? 10.54666  -11.30344 33.06842  1.000 29.12187  ? 562 MET   A CE   1 
ATOM   2926 H H    . MET   A 1 200 ? 14.79011  -13.87175 33.31571  1.000 40.36269  ? 562 MET   A H    1 
ATOM   2927 H HA   . MET   A 1 200 ? 15.70771  -11.43644 34.05653  1.000 31.19742  ? 562 MET   A HA   1 
ATOM   2928 H HB2  . MET   A 1 200 ? 13.06898  -12.38035 34.42121  1.000 35.56616  ? 562 MET   A HB2  1 
ATOM   2929 H HB3  . MET   A 1 200 ? 13.61514  -11.03537 35.06786  1.000 35.56616  ? 562 MET   A HB3  1 
ATOM   2930 H HG2  . MET   A 1 200 ? 13.97341  -10.22714 32.85498  1.000 41.79077  ? 562 MET   A HG2  1 
ATOM   2931 H HG3  . MET   A 1 200 ? 13.18382  -11.50220 32.32947  1.000 41.79077  ? 562 MET   A HG3  1 
ATOM   2932 H HE1  . MET   A 1 200 ? 9.65219   -10.93777 33.15272  1.000 34.95830  ? 562 MET   A HE1  1 
ATOM   2933 H HE2  . MET   A 1 200 ? 10.65511  -11.71463 32.19661  1.000 34.95830  ? 562 MET   A HE2  1 
ATOM   2934 H HE3  . MET   A 1 200 ? 10.70274  -11.95975 33.76541  1.000 34.95830  ? 562 MET   A HE3  1 
ATOM   2935 N N    . ARG   A 1 201 ? 16.55926  -13.63246 35.53748  1.000 29.30711  ? 563 ARG   A N    1 
ATOM   2936 C CA   . ARG   A 1 201 ? 17.02181  -14.24438 36.76707  1.000 33.80547  ? 563 ARG   A CA   1 
ATOM   2937 C C    . ARG   A 1 201 ? 17.97919  -13.28684 37.44974  1.000 30.24435  ? 563 ARG   A C    1 
ATOM   2938 O O    . ARG   A 1 201 ? 18.46704  -12.34202 36.83740  1.000 30.42321  ? 563 ARG   A O    1 
ATOM   2939 C CB   . ARG   A 1 201 ? 17.73617  -15.56716 36.49711  1.000 31.92065  ? 563 ARG   A CB   1 
ATOM   2940 C CG   . ARG   A 1 201 ? 16.87254  -16.58778 35.79087  1.000 31.24976  ? 563 ARG   A CG   1 
ATOM   2941 C CD   . ARG   A 1 201 ? 15.67946  -16.95910 36.61955  1.000 35.59172  ? 563 ARG   A CD   1 
ATOM   2942 N NE   . ARG   A 1 201 ? 15.09373  -18.19570 36.11459  1.000 41.86608  ? 563 ARG   A NE   1 
ATOM   2943 C CZ   . ARG   A 1 201 ? 13.84747  -18.60603 36.31600  1.000 48.50839  ? 563 ARG   A CZ   1 
ATOM   2944 N NH1  . ARG   A 1 201 ? 12.97178  -17.86625 36.97768  1.000 49.59931  ? 563 ARG   A NH1  1 
ATOM   2945 N NH2  . ARG   A 1 201 ? 13.48104  -19.80490 35.86458  1.000 46.92013  ? 563 ARG   A NH2  1 
ATOM   2946 H H    . ARG   A 1 201 ? 17.01431  -13.83685 34.83694  1.000 35.18059  ? 563 ARG   A H    1 
ATOM   2947 H HA   . ARG   A 1 201 ? 16.26627  -14.43615 37.34438  1.000 40.57862  ? 563 ARG   A HA   1 
ATOM   2948 H HB2  . ARG   A 1 201 ? 18.51040  -15.39584 35.93843  1.000 38.31683  ? 563 ARG   A HB2  1 
ATOM   2949 H HB3  . ARG   A 1 201 ? 18.01590  -15.94965 37.34348  1.000 38.31683  ? 563 ARG   A HB3  1 
ATOM   2950 H HG2  . ARG   A 1 201 ? 16.55819  -16.21776 34.95112  1.000 37.51177  ? 563 ARG   A HG2  1 
ATOM   2951 H HG3  . ARG   A 1 201 ? 17.39191  -17.39027 35.62606  1.000 37.51177  ? 563 ARG   A HG3  1 
ATOM   2952 H HD2  . ARG   A 1 201 ? 15.95006  -17.09519 37.54104  1.000 42.72211  ? 563 ARG   A HD2  1 
ATOM   2953 H HD3  . ARG   A 1 201 ? 15.01396  -16.25516 36.56971  1.000 42.72211  ? 563 ARG   A HD3  1 
ATOM   2954 H HE   . ARG   A 1 201 ? 15.60185  -18.70523 35.64364  1.000 50.25135  ? 563 ARG   A HE   1 
ATOM   2955 H HH11 . ARG   A 1 201 ? 13.20506  -17.09933 37.28914  1.000 59.53122  ? 563 ARG   A HH11 1 
ATOM   2956 H HH12 . ARG   A 1 201 ? 12.16952  -18.15252 37.09615  1.000 59.53122  ? 563 ARG   A HH12 1 
ATOM   2957 H HH21 . ARG   A 1 201 ? 14.04874  -20.30012 35.44977  1.000 56.31621  ? 563 ARG   A HH21 1 
ATOM   2958 H HH22 . ARG   A 1 201 ? 12.67682  -20.08347 35.98802  1.000 56.31621  ? 563 ARG   A HH22 1 
ATOM   2959 N N    . THR   A 1 202 ? 18.24309  -13.55588 38.72167  1.000 31.34519  ? 564 THR   A N    1 
ATOM   2960 C CA   . THR   A 1 202 ? 19.30161  -12.86650 39.43283  1.000 32.75241  ? 564 THR   A CA   1 
ATOM   2961 C C    . THR   A 1 202 ? 20.57607  -12.88921 38.60783  1.000 32.35941  ? 564 THR   A C    1 
ATOM   2962 O O    . THR   A 1 202 ? 20.96119  -13.92799 38.09150  1.000 33.45559  ? 564 THR   A O    1 
ATOM   2963 C CB   . THR   A 1 202 ? 19.50452  -13.51817 40.78972  1.000 33.86686  ? 564 THR   A CB   1 
ATOM   2964 O OG1  . THR   A 1 202 ? 18.24385  -13.48316 41.48704  1.000 34.29774  ? 564 THR   A OG1  1 
ATOM   2965 C CG2  . THR   A 1 202 ? 20.58546  -12.75305 41.59926  1.000 34.89678  ? 564 THR   A CG2  1 
ATOM   2966 H H    . THR   A 1 202 ? 17.82042  -14.13624 39.19510  1.000 37.62629  ? 564 THR   A H    1 
ATOM   2967 H HA   . THR   A 1 202 ? 19.06337  -11.93892 39.58688  1.000 39.31494  ? 564 THR   A HA   1 
ATOM   2968 H HB   . THR   A 1 202 ? 19.80769  -14.43471 40.69513  1.000 40.65229  ? 564 THR   A HB   1 
ATOM   2969 H HG1  . THR   A 1 202 ? 18.33031  -13.81524 42.25376  1.000 41.16934  ? 564 THR   A HG1  1 
ATOM   2970 H HG21 . THR   A 1 202 ? 20.59980  -13.07012 42.51587  1.000 41.88820  ? 564 THR   A HG21 1 
ATOM   2971 H HG22 . THR   A 1 202 ? 21.45936  -12.89555 41.20317  1.000 41.88820  ? 564 THR   A HG22 1 
ATOM   2972 H HG23 . THR   A 1 202 ? 20.39035  -11.80288 41.59786  1.000 41.88820  ? 564 THR   A HG23 1 
ATOM   2973 N N    . ASP   A 1 203 ? 21.16804  -11.70956 38.41297  1.000 30.05412  ? 565 ASP   A N    1 
ATOM   2974 C CA   . ASP   A 1 203 ? 22.38206  -11.46919 37.64160  1.000 33.96529  ? 565 ASP   A CA   1 
ATOM   2975 C C    . ASP   A 1 203 ? 22.10463  -11.38607 36.14418  1.000 30.83779  ? 565 ASP   A C    1 
ATOM   2976 O O    . ASP   A 1 203 ? 23.05099  -11.10175 35.40007  1.000 33.71789  ? 565 ASP   A O    1 
ATOM   2977 C CB   . ASP   A 1 203 ? 23.49558  -12.51806 37.82808  1.000 31.77320  ? 565 ASP   A CB   1 
ATOM   2978 C CG   . ASP   A 1 203 ? 23.96589  -12.65660 39.27210  1.000 43.98171  ? 565 ASP   A CG   1 
ATOM   2979 O OD1  . ASP   A 1 203 ? 23.79869  -11.72077 40.07574  1.000 44.82645  ? 565 ASP   A OD1  1 
ATOM   2980 O OD2  . ASP   A 1 203 ? 24.53098  -13.72600 39.59644  1.000 53.69363  ? 565 ASP   A OD2  1 
ATOM   2981 H H    . ASP   A 1 203 ? 20.85527  -10.98121 38.74654  1.000 36.07700  ? 565 ASP   A H    1 
ATOM   2982 H HA   . ASP   A 1 203 ? 22.72692  -10.61979 37.95860  1.000 40.77041  ? 565 ASP   A HA   1 
ATOM   2983 H HB2  . ASP   A 1 203 ? 23.16283  -13.38254 37.54025  1.000 38.13989  ? 565 ASP   A HB2  1 
ATOM   2984 H HB3  . ASP   A 1 203 ? 24.26086  -12.26129 37.29020  1.000 38.13989  ? 565 ASP   A HB3  1 
ATOM   2985 N N    . ASP   A 1 204 ? 20.88210  -11.62266 35.65918  1.000 28.98745  ? 566 ASP   A N    1 
ATOM   2986 C CA   . ASP   A 1 204 ? 20.63013  -11.29705 34.26002  1.000 29.79611  ? 566 ASP   A CA   1 
ATOM   2987 C C    . ASP   A 1 204 ? 20.59665  -9.77633  34.09956  1.000 25.66740  ? 566 ASP   A C    1 
ATOM   2988 O O    . ASP   A 1 204 ? 20.29436  -9.04893  35.03400  1.000 30.77539  ? 566 ASP   A O    1 
ATOM   2989 C CB   . ASP   A 1 204 ? 19.32459  -11.90278 33.76364  1.000 30.56497  ? 566 ASP   A CB   1 
ATOM   2990 C CG   . ASP   A 1 204 ? 19.43377  -13.40391 33.51995  1.000 35.67558  ? 566 ASP   A CG   1 
ATOM   2991 O OD1  . ASP   A 1 204 ? 20.53728  -13.90318 33.18280  1.000 40.48630  ? 566 ASP   A OD1  1 
ATOM   2992 O OD2  . ASP   A 1 204 ? 18.41181  -14.08896 33.71296  1.000 36.82472  ? 566 ASP   A OD2  1 
ATOM   2993 H H    . ASP   A 1 204 ? 20.22028  -11.95284 36.09802  1.000 34.79700  ? 566 ASP   A H    1 
ATOM   2994 H HA   . ASP   A 1 204 ? 21.33500  -11.67018 33.70790  1.000 35.76739  ? 566 ASP   A HA   1 
ATOM   2995 H HB2  . ASP   A 1 204 ? 18.63358  -11.75510 34.42817  1.000 36.69002  ? 566 ASP   A HB2  1 
ATOM   2996 H HB3  . ASP   A 1 204 ? 19.07630  -11.47921 32.92707  1.000 36.69002  ? 566 ASP   A HB3  1 
ATOM   2997 N N    . ILE   A 1 205 ? 20.88930  -9.31470  32.89634  1.000 31.73969  ? 567 ILE   A N    1 
ATOM   2998 C CA   . ILE   A 1 205 ? 21.16730  -7.91453  32.61775  1.000 28.36066  ? 567 ILE   A CA   1 
ATOM   2999 C C    . ILE   A 1 205 ? 19.93505  -7.31875  31.95043  1.000 29.40640  ? 567 ILE   A C    1 
ATOM   3000 O O    . ILE   A 1 205 ? 19.49545  -7.81310  30.91002  1.000 23.73524  ? 567 ILE   A O    1 
ATOM   3001 C CB   . ILE   A 1 205 ? 22.38711  -7.76775  31.69925  1.000 27.36074  ? 567 ILE   A CB   1 
ATOM   3002 C CG1  . ILE   A 1 205 ? 23.55450  -8.61406  32.19185  1.000 39.97048  ? 567 ILE   A CG1  1 
ATOM   3003 C CG2  . ILE   A 1 205 ? 22.74814  -6.29277  31.52128  1.000 29.91608  ? 567 ILE   A CG2  1 
ATOM   3004 C CD1  . ILE   A 1 205 ? 23.97671  -8.32819  33.57005  1.000 35.60638  ? 567 ILE   A CD1  1 
ATOM   3005 H H    . ILE   A 1 205 ? 20.93508  -9.81201  32.19621  1.000 38.09968  ? 567 ILE   A H    1 
ATOM   3006 H HA   . ILE   A 1 205 ? 21.33707  -7.44687  33.45045  1.000 34.04485  ? 567 ILE   A HA   1 
ATOM   3007 H HB   . ILE   A 1 205 ? 22.15861  -8.11162  30.82150  1.000 32.84494  ? 567 ILE   A HB   1 
ATOM   3008 H HG12 . ILE   A 1 205 ? 23.29689  -9.54840  32.15246  1.000 47.97663  ? 567 ILE   A HG12 1 
ATOM   3009 H HG13 . ILE   A 1 205 ? 24.31676  -8.45542  31.61332  1.000 47.97663  ? 567 ILE   A HG13 1 
ATOM   3010 H HG21 . ILE   A 1 205 ? 23.60903  -6.22953  31.07881  1.000 35.91134  ? 567 ILE   A HG21 1 
ATOM   3011 H HG22 . ILE   A 1 205 ? 22.06626  -5.86370  30.98105  1.000 35.91134  ? 567 ILE   A HG22 1 
ATOM   3012 H HG23 . ILE   A 1 205 ? 22.79285  -5.87110  32.39369  1.000 35.91134  ? 567 ILE   A HG23 1 
ATOM   3013 H HD11 . ILE   A 1 205 ? 24.82275  -8.77136  33.73952  1.000 42.73971  ? 567 ILE   A HD11 1 
ATOM   3014 H HD12 . ILE   A 1 205 ? 24.07829  -7.36945  33.67679  1.000 42.73971  ? 567 ILE   A HD12 1 
ATOM   3015 H HD13 . ILE   A 1 205 ? 23.30129  -8.65946  34.18240  1.000 42.73971  ? 567 ILE   A HD13 1 
ATOM   3016 N N    . GLY   A 1 206 ? 19.38523  -6.25903  32.54714  1.000 29.02290  ? 568 GLY   A N    1 
ATOM   3017 C CA   . GLY   A 1 206 ? 18.35128  -5.46929  31.91863  1.000 27.72803  ? 568 GLY   A CA   1 
ATOM   3018 C C    . GLY   A 1 206 ? 18.88108  -4.09858  31.53413  1.000 27.03265  ? 568 GLY   A C    1 
ATOM   3019 O O    . GLY   A 1 206 ? 19.95989  -3.67153  31.94862  1.000 28.96339  ? 568 GLY   A O    1 
ATOM   3020 H H    . GLY   A 1 206 ? 19.60542  -5.98083  33.33054  1.000 34.83954  ? 568 GLY   A H    1 
ATOM   3021 H HA2  . GLY   A 1 206 ? 18.03657  -5.91855  31.11861  1.000 33.28570  ? 568 GLY   A HA2  1 
ATOM   3022 H HA3  . GLY   A 1 206 ? 17.60739  -5.35653  32.53084  1.000 33.28570  ? 568 GLY   A HA3  1 
ATOM   3023 N N    . THR   A 1 207 ? 18.09258  -3.38411  30.75252  1.000 25.76332  ? 569 THR   A N    1 
ATOM   3024 C CA   . THR   A 1 207 ? 18.47956  -2.04564  30.34291  1.000 24.79965  ? 569 THR   A CA   1 
ATOM   3025 C C    . THR   A 1 207 ? 17.40341  -1.04442  30.70989  1.000 25.53187  ? 569 THR   A C    1 
ATOM   3026 O O    . THR   A 1 207 ? 16.22306  -1.25251  30.41659  1.000 26.54654  ? 569 THR   A O    1 
ATOM   3027 C CB   . THR   A 1 207 ? 18.77733  -1.99711  28.85963  1.000 28.15732  ? 569 THR   A CB   1 
ATOM   3028 O OG1  . THR   A 1 207 ? 19.83103  -2.91527  28.56625  1.000 24.82376  ? 569 THR   A OG1  1 
ATOM   3029 C CG2  . THR   A 1 207 ? 19.22088  -0.58482  28.45672  1.000 27.81154  ? 569 THR   A CG2  1 
ATOM   3030 H H    . THR   A 1 207 ? 17.33362  -3.65056  30.44826  1.000 30.92804  ? 569 THR   A H    1 
ATOM   3031 H HA   . THR   A 1 207 ? 19.28104  -1.78879  30.82514  1.000 29.77163  ? 569 THR   A HA   1 
ATOM   3032 H HB   . THR   A 1 207 ? 17.98335  -2.23124  28.35399  1.000 33.80084  ? 569 THR   A HB   1 
ATOM   3033 H HG1  . THR   A 1 207 ? 20.51451  -2.72089  29.01421  1.000 29.80056  ? 569 THR   A HG1  1 
ATOM   3034 H HG21 . THR   A 1 207 ? 19.71256  -0.61722  27.62119  1.000 33.38590  ? 569 THR   A HG21 1 
ATOM   3035 H HG22 . THR   A 1 207 ? 18.44544  -0.01314  28.34369  1.000 33.38590  ? 569 THR   A HG22 1 
ATOM   3036 H HG23 . THR   A 1 207 ? 19.79240  -0.20788  29.14388  1.000 33.38590  ? 569 THR   A HG23 1 
ATOM   3037 N N    . ALA   A 1 208 ? 17.81305  0.01732   31.39140  1.000 24.69247  ? 570 ALA   A N    1 
ATOM   3038 C CA   . ALA   A 1 208 ? 16.92181  1.09918   31.74032  1.000 26.26164  ? 570 ALA   A CA   1 
ATOM   3039 C C    . ALA   A 1 208 ? 17.32604  2.30414   30.90809  1.000 24.94189  ? 570 ALA   A C    1 
ATOM   3040 O O    . ALA   A 1 208 ? 18.51879  2.56302   30.70205  1.000 25.80506  ? 570 ALA   A O    1 
ATOM   3041 C CB   . ALA   A 1 208 ? 16.97679  1.42937   33.23033  1.000 29.68131  ? 570 ALA   A CB   1 
ATOM   3042 H H    . ALA   A 1 208 ? 18.62033  0.13023   31.66551  1.000 29.64302  ? 570 ALA   A H    1 
ATOM   3043 H HA   . ALA   A 1 208 ? 16.00080  0.86117   31.55060  1.000 31.52602  ? 570 ALA   A HA   1 
ATOM   3044 H HB1  . ALA   A 1 208 ? 16.34712  2.14264   33.41917  1.000 35.62962  ? 570 ALA   A HB1  1 
ATOM   3045 H HB2  . ALA   A 1 208 ? 16.74136  0.63722   33.73823  1.000 35.62962  ? 570 ALA   A HB2  1 
ATOM   3046 H HB3  . ALA   A 1 208 ? 17.87601  1.71310   33.45794  1.000 35.62962  ? 570 ALA   A HB3  1 
ATOM   3047 N N    . SER   A 1 209 ? 16.33158  3.01071   30.40572  1.000 24.55095  ? 571 SER   A N    1 
ATOM   3048 C CA   . SER   A 1 209 ? 16.56529  4.18608   29.59188  1.000 25.67130  ? 571 SER   A CA   1 
ATOM   3049 C C    . SER   A 1 209 ? 15.67831  5.31848   30.08380  1.000 25.32474  ? 571 SER   A C    1 
ATOM   3050 O O    . SER   A 1 209 ? 14.60452  5.09276   30.63839  1.000 25.82724  ? 571 SER   A O    1 
ATOM   3051 C CB   . SER   A 1 209 ? 16.30948  3.88120   28.14339  1.000 28.36683  ? 571 SER   A CB   1 
ATOM   3052 O OG   . SER   A 1 209 ? 14.98856  3.37572   27.92517  1.000 26.97925  ? 571 SER   A OG   1 
ATOM   3053 H H    . SER   A 1 209 ? 15.49998  2.82632   30.52420  1.000 29.47319  ? 571 SER   A H    1 
ATOM   3054 H HA   . SER   A 1 209 ? 17.48357  4.48805   29.67238  1.000 30.81762  ? 571 SER   A HA   1 
ATOM   3055 H HB2  . SER   A 1 209 ? 16.41883  4.69695   27.63007  1.000 34.05226  ? 571 SER   A HB2  1 
ATOM   3056 H HB3  . SER   A 1 209 ? 16.94986  3.21511   27.84819  1.000 34.05226  ? 571 SER   A HB3  1 
ATOM   3057 H HG   . SER   A 1 209 ? 14.42004  3.95734   28.13516  1.000 32.38715  ? 571 SER   A HG   1 
ATOM   3058 N N    . GLY   A 1 210 ? 16.14465  6.54418   29.89613  1.000 24.67516  ? 572 GLY   A N    1 
ATOM   3059 C CA   . GLY   A 1 210 ? 15.38452  7.66955   30.39150  1.000 22.70851  ? 572 GLY   A CA   1 
ATOM   3060 C C    . GLY   A 1 210 ? 16.15033  8.96450   30.26299  1.000 27.62374  ? 572 GLY   A C    1 
ATOM   3061 O O    . GLY   A 1 210 ? 17.34305  8.99201   29.91734  1.000 25.99064  ? 572 GLY   A O    1 
ATOM   3062 H H    . GLY   A 1 210 ? 16.87943  6.74163   29.49525  1.000 29.62224  ? 572 GLY   A H    1 
ATOM   3063 H HA2  . GLY   A 1 210 ? 14.55900  7.74927   29.88845  1.000 27.26227  ? 572 GLY   A HA2  1 
ATOM   3064 H HA3  . GLY   A 1 210 ? 15.17173  7.52971   31.32748  1.000 27.26227  ? 572 GLY   A HA3  1 
ATOM   3065 N N    . TRP   A 1 211 ? 15.40832  10.05784  30.49238  1.000 25.88492  ? 573 TRP   A N    1 
ATOM   3066 C CA   . TRP   A 1 211 ? 15.95281  11.40636  30.58016  1.000 26.15410  ? 573 TRP   A CA   1 
ATOM   3067 C C    . TRP   A 1 211 ? 16.05379  11.89736  32.02065  1.000 26.04416  ? 573 TRP   A C    1 
ATOM   3068 O O    . TRP   A 1 211 ? 16.13603  13.11182  32.26191  1.000 29.67935  ? 573 TRP   A O    1 
ATOM   3069 C CB   . TRP   A 1 211 ? 15.08369  12.37460  29.78985  1.000 26.53926  ? 573 TRP   A CB   1 
ATOM   3070 C CG   . TRP   A 1 211 ? 15.00993  12.13109  28.34086  1.000 27.88179  ? 573 TRP   A CG   1 
ATOM   3071 C CD1  . TRP   A 1 211 ? 15.90654  12.53537  27.40333  1.000 29.81246  ? 573 TRP   A CD1  1 
ATOM   3072 C CD2  . TRP   A 1 211 ? 13.96278  11.45985  27.63833  1.000 26.35759  ? 573 TRP   A CD2  1 
ATOM   3073 N NE1  . TRP   A 1 211 ? 15.48368  12.15849  26.15496  1.000 25.87585  ? 573 TRP   A NE1  1 
ATOM   3074 C CE2  . TRP   A 1 211 ? 14.29737  11.48074  26.27517  1.000 25.36925  ? 573 TRP   A CE2  1 
ATOM   3075 C CE3  . TRP   A 1 211 ? 12.77809  10.82940  28.03418  1.000 27.82526  ? 573 TRP   A CE3  1 
ATOM   3076 C CZ2  . TRP   A 1 211 ? 13.47717  10.91504  25.29796  1.000 26.44831  ? 573 TRP   A CZ2  1 
ATOM   3077 C CZ3  . TRP   A 1 211 ? 11.97071  10.24295  27.05815  1.000 29.53525  ? 573 TRP   A CZ3  1 
ATOM   3078 C CH2  . TRP   A 1 211 ? 12.31634  10.30050  25.71494  1.000 30.42078  ? 573 TRP   A CH2  1 
ATOM   3079 H H    . TRP   A 1 211 ? 14.55585  10.03537  30.60367  1.000 31.07396  ? 573 TRP   A H    1 
ATOM   3080 H HA   . TRP   A 1 211 ? 16.84222  11.39548  30.19321  1.000 31.39697  ? 573 TRP   A HA   1 
ATOM   3081 H HB2  . TRP   A 1 211 ? 14.17909  12.32352  30.13625  1.000 31.85917  ? 573 TRP   A HB2  1 
ATOM   3082 H HB3  . TRP   A 1 211 ? 15.43614  13.26984  29.91322  1.000 31.85917  ? 573 TRP   A HB3  1 
ATOM   3083 H HD1  . TRP   A 1 211 ? 16.69213  12.99979  27.58235  1.000 35.78700  ? 573 TRP   A HD1  1 
ATOM   3084 H HE1  . TRP   A 1 211 ? 15.89491  12.32050  25.41723  1.000 31.06307  ? 573 TRP   A HE1  1 
ATOM   3085 H HE3  . TRP   A 1 211 ? 12.53313  10.80159  28.93090  1.000 33.40236  ? 573 TRP   A HE3  1 
ATOM   3086 H HZ2  . TRP   A 1 211 ? 13.70590  10.95150  24.39727  1.000 31.75003  ? 573 TRP   A HZ2  1 
ATOM   3087 H HZ3  . TRP   A 1 211 ? 11.18929  9.80701   27.31162  1.000 35.45435  ? 573 TRP   A HZ3  1 
ATOM   3088 H HH2  . TRP   A 1 211 ? 11.75252  9.91616   25.08303  1.000 36.51699  ? 573 TRP   A HH2  1 
ATOM   3089 N N    . GLY   A 1 212 ? 16.04359  10.98623  32.97399  1.000 24.93697  ? 574 GLY   A N    1 
ATOM   3090 C CA   . GLY   A 1 212 ? 16.00653  11.33725  34.37094  1.000 25.85424  ? 574 GLY   A CA   1 
ATOM   3091 C C    . GLY   A 1 212 ? 17.35314  11.79338  34.89145  1.000 28.35295  ? 574 GLY   A C    1 
ATOM   3092 O O    . GLY   A 1 212 ? 18.32955  11.95559  34.15739  1.000 23.14084  ? 574 GLY   A O    1 
ATOM   3093 H H    . GLY   A 1 212 ? 16.05802  10.13833  32.83091  1.000 29.93642  ? 574 GLY   A H    1 
ATOM   3094 H HA2  . GLY   A 1 212 ? 15.36887  12.05604  34.50376  1.000 31.03714  ? 574 GLY   A HA2  1 
ATOM   3095 H HA3  . GLY   A 1 212 ? 15.72519  10.56603  34.88762  1.000 31.03714  ? 574 GLY   A HA3  1 
ATOM   3096 N N    . LEU   A 1 213 ? 17.37777  12.06176  36.19260  1.000 24.58049  ? 575 LEU   A N    1 
ATOM   3097 C CA   . LEU   A 1 213 ? 18.59389  12.57163  36.81312  1.000 27.84345  ? 575 LEU   A CA   1 
ATOM   3098 C C    . LEU   A 1 213 ? 19.78606  11.68541  36.49757  1.000 31.81446  ? 575 LEU   A C    1 
ATOM   3099 O O    . LEU   A 1 213 ? 19.67307  10.45473  36.43915  1.000 30.00093  ? 575 LEU   A O    1 
ATOM   3100 C CB   . LEU   A 1 213 ? 18.45024  12.67244  38.32766  1.000 24.54209  ? 575 LEU   A CB   1 
ATOM   3101 C CG   . LEU   A 1 213 ? 17.39703  13.54180  38.97343  1.000 29.79796  ? 575 LEU   A CG   1 
ATOM   3102 C CD1  . LEU   A 1 213 ? 17.78242  13.78611  40.41570  1.000 27.02620  ? 575 LEU   A CD1  1 
ATOM   3103 C CD2  . LEU   A 1 213 ? 17.20299  14.84684  38.22998  1.000 32.90825  ? 575 LEU   A CD2  1 
ATOM   3104 H H    . LEU   A 1 213 ? 16.71414  11.95892  36.72983  1.000 29.50864  ? 575 LEU   A H    1 
ATOM   3105 H HA   . LEU   A 1 213 ? 18.74970  13.46081  36.45818  1.000 33.42419  ? 575 LEU   A HA   1 
ATOM   3106 H HB2  . LEU   A 1 213 ? 18.28249  11.77393  38.65237  1.000 29.46257  ? 575 LEU   A HB2  1 
ATOM   3107 H HB3  . LEU   A 1 213 ? 19.29960  12.99486  38.66757  1.000 29.46257  ? 575 LEU   A HB3  1 
ATOM   3108 H HG   . LEU   A 1 213 ? 16.54106  13.08659  38.94184  1.000 35.76961  ? 575 LEU   A HG   1 
ATOM   3109 H HD11 . LEU   A 1 213 ? 17.01378  14.13566  40.89311  1.000 32.44350  ? 575 LEU   A HD11 1 
ATOM   3110 H HD12 . LEU   A 1 213 ? 18.06557  12.94786  40.81326  1.000 32.44350  ? 575 LEU   A HD12 1 
ATOM   3111 H HD13 . LEU   A 1 213 ? 18.50926  14.42783  40.44400  1.000 32.44350  ? 575 LEU   A HD13 1 
ATOM   3112 H HD21 . LEU   A 1 213 ? 16.56267  15.39291  38.71236  1.000 39.50195  ? 575 LEU   A HD21 1 
ATOM   3113 H HD22 . LEU   A 1 213 ? 18.05461  15.30776  38.17351  1.000 39.50195  ? 575 LEU   A HD22 1 
ATOM   3114 H HD23 . LEU   A 1 213 ? 16.87031  14.65626  37.33897  1.000 39.50195  ? 575 LEU   A HD23 1 
ATOM   3115 N N    . THR   A 1 214 ? 20.91165  12.33395  36.23762  1.000 30.22061  ? 576 THR   A N    1 
ATOM   3116 C CA   . THR   A 1 214 ? 22.17140  11.65825  36.02612  1.000 34.47388  ? 576 THR   A CA   1 
ATOM   3117 C C    . THR   A 1 214 ? 23.00907  11.80348  37.27942  1.000 30.59005  ? 576 THR   A C    1 
ATOM   3118 O O    . THR   A 1 214 ? 22.55252  12.32133  38.30146  1.000 26.16428  ? 576 THR   A O    1 
ATOM   3119 C CB   . THR   A 1 214 ? 22.91357  12.21556  34.81410  1.000 34.52021  ? 576 THR   A CB   1 
ATOM   3120 O OG1  . THR   A 1 214 ? 23.58365  13.42598  35.18458  1.000 37.86503  ? 576 THR   A OG1  1 
ATOM   3121 C CG2  . THR   A 1 214 ? 21.95638  12.51545  33.69879  1.000 31.73750  ? 576 THR   A CG2  1 
ATOM   3122 H H    . THR   A 1 214 ? 20.96770  13.19004  36.17798  1.000 36.27679  ? 576 THR   A H    1 
ATOM   3123 H HA   . THR   A 1 214 ? 21.99809  10.72061  35.84807  1.000 41.38071  ? 576 THR   A HA   1 
ATOM   3124 H HB   . THR   A 1 214 ? 23.55725  11.56065  34.50157  1.000 41.43630  ? 576 THR   A HB   1 
ATOM   3125 H HG1  . THR   A 1 214 ? 23.92092  13.78714  34.50531  1.000 45.45010  ? 576 THR   A HG1  1 
ATOM   3126 H HG21 . THR   A 1 214 ? 22.43997  12.61181  32.86347  1.000 38.09705  ? 576 THR   A HG21 1 
ATOM   3127 H HG22 . THR   A 1 214 ? 21.31445  11.79374  33.60946  1.000 38.09705  ? 576 THR   A HG22 1 
ATOM   3128 H HG23 . THR   A 1 214 ? 21.47961  13.33976  33.88342  1.000 38.09705  ? 576 THR   A HG23 1 
ATOM   3129 N N    . GLN   A 1 215 ? 24.23558  11.28900  37.20832  1.000 36.18026  ? 577 GLN   A N    1 
ATOM   3130 C CA   . GLN   A 1 215 ? 25.17518  11.44449  38.31842  1.000 43.13047  ? 577 GLN   A CA   1 
ATOM   3131 C C    . GLN   A 1 215 ? 25.48073  12.90909  38.59343  1.000 36.37279  ? 577 GLN   A C    1 
ATOM   3132 O O    . GLN   A 1 215 ? 25.85665  13.25830  39.70930  1.000 35.73065  ? 577 GLN   A O    1 
ATOM   3133 C CB   . GLN   A 1 215 ? 26.48061  10.69205  38.02691  1.000 41.91416  ? 577 GLN   A CB   1 
ATOM   3134 C CG   . GLN   A 1 215 ? 27.12396  11.00087  36.66028  1.000 56.94107  ? 577 GLN   A CG   1 
ATOM   3135 C CD   . GLN   A 1 215 ? 26.77412  9.98638   35.55248  1.000 59.48232  ? 577 GLN   A CD   1 
ATOM   3136 O OE1  . GLN   A 1 215 ? 25.59859  9.66778   35.30919  1.000 34.32299  ? 577 GLN   A OE1  1 
ATOM   3137 N NE2  . GLN   A 1 215 ? 27.80490  9.48368   34.87697  1.000 56.76553  ? 577 GLN   A NE2  1 
ATOM   3138 H H    . GLN   A 1 215 ? 24.54602  10.85038  36.53688  1.000 43.42837  ? 577 GLN   A H    1 
ATOM   3139 H HA   . GLN   A 1 215 ? 24.78150  11.05472  39.11466  1.000 51.76861  ? 577 GLN   A HA   1 
ATOM   3140 H HB2  . GLN   A 1 215 ? 27.12754  10.92446  38.71129  1.000 50.30905  ? 577 GLN   A HB2  1 
ATOM   3141 H HB3  . GLN   A 1 215 ? 26.29771  9.73981   38.05295  1.000 50.30905  ? 577 GLN   A HB3  1 
ATOM   3142 H HG2  . GLN   A 1 215 ? 26.82166  11.87400  36.36505  1.000 68.34133  ? 577 GLN   A HG2  1 
ATOM   3143 H HG3  . GLN   A 1 215 ? 28.08838  11.00134  36.76417  1.000 68.34133  ? 577 GLN   A HG3  1 
ATOM   3144 H HE21 . GLN   A 1 215 ? 28.60623  9.72923   35.06976  1.000 68.13069  ? 577 GLN   A HE21 1 
ATOM   3145 H HE22 . GLN   A 1 215 ? 27.66959  8.91332   34.24770  1.000 68.13069  ? 577 GLN   A HE22 1 
ATOM   3146 N N    . ARG   A 1 216 ? 25.32823  13.77951  37.60202  1.000 38.48199  ? 578 ARG   A N    1 
ATOM   3147 C CA   . ARG   A 1 216 ? 25.48058  15.20134  37.86016  1.000 34.83465  ? 578 ARG   A CA   1 
ATOM   3148 C C    . ARG   A 1 216 ? 24.32583  15.78480  38.65965  1.000 35.73047  ? 578 ARG   A C    1 
ATOM   3149 O O    . ARG   A 1 216 ? 24.43275  16.92828  39.11355  1.000 34.36112  ? 578 ARG   A O    1 
ATOM   3150 C CB   . ARG   A 1 216 ? 25.61404  15.94544  36.54444  1.000 38.38126  ? 578 ARG   A CB   1 
ATOM   3151 C CG   . ARG   A 1 216 ? 26.71348  15.40607  35.66079  1.000 37.74821  ? 578 ARG   A CG   1 
ATOM   3152 C CD   . ARG   A 1 216 ? 27.15208  16.43002  34.62853  1.000 38.00448  ? 578 ARG   A CD   1 
ATOM   3153 N NE   . ARG   A 1 216 ? 26.04201  16.84881  33.77989  1.000 42.12604  ? 578 ARG   A NE   1 
ATOM   3154 C CZ   . ARG   A 1 216 ? 25.42645  18.02973  33.80982  1.000 39.64589  ? 578 ARG   A CZ   1 
ATOM   3155 N NH1  . ARG   A 1 216 ? 25.73845  18.96522  34.68898  1.000 39.69193  ? 578 ARG   A NH1  1 
ATOM   3156 N NH2  . ARG   A 1 216 ? 24.46683  18.27745  32.92664  1.000 44.04453  ? 578 ARG   A NH2  1 
ATOM   3157 H H    . ARG   A 1 216 ? 25.14022  13.57451  36.78824  1.000 46.19044  ? 578 ARG   A H    1 
ATOM   3158 H HA   . ARG   A 1 216 ? 26.29209  15.33888  38.37342  1.000 41.81364  ? 578 ARG   A HA   1 
ATOM   3159 H HB2  . ARG   A 1 216 ? 24.77820  15.87348  36.05752  1.000 46.06957  ? 578 ARG   A HB2  1 
ATOM   3160 H HB3  . ARG   A 1 216 ? 25.81085  16.87700  36.72981  1.000 46.06957  ? 578 ARG   A HB3  1 
ATOM   3161 H HG2  . ARG   A 1 216 ? 27.48119  15.17635  36.20736  1.000 45.30991  ? 578 ARG   A HG2  1 
ATOM   3162 H HG3  . ARG   A 1 216 ? 26.39238  14.61963  35.19249  1.000 45.30991  ? 578 ARG   A HG3  1 
ATOM   3163 H HD2  . ARG   A 1 216 ? 27.50072  17.21331  35.08220  1.000 45.61743  ? 578 ARG   A HD2  1 
ATOM   3164 H HD3  . ARG   A 1 216 ? 27.83778  16.04151  34.06304  1.000 45.61743  ? 578 ARG   A HD3  1 
ATOM   3165 H HE   . ARG   A 1 216 ? 25.75708  16.27734  33.20384  1.000 50.56331  ? 578 ARG   A HE   1 
ATOM   3166 H HH11 . ARG   A 1 216 ? 26.35791  18.82171  35.26801  1.000 47.64237  ? 578 ARG   A HH11 1 
ATOM   3167 H HH12 . ARG   A 1 216 ? 25.32210  19.71768  34.68224  1.000 47.64237  ? 578 ARG   A HH12 1 
ATOM   3168 H HH21 . ARG   A 1 216 ? 24.25123  17.67987  32.34697  1.000 52.86549  ? 578 ARG   A HH21 1 
ATOM   3169 H HH22 . ARG   A 1 216 ? 24.06076  19.03551  32.93415  1.000 52.86549  ? 578 ARG   A HH22 1 
ATOM   3170 N N    . GLY   A 1 217 ? 23.23037  15.05423  38.81421  1.000 32.42021  ? 579 GLY   A N    1 
ATOM   3171 C CA   . GLY   A 1 217 ? 22.10014  15.51706  39.58938  1.000 29.94406  ? 579 GLY   A CA   1 
ATOM   3172 C C    . GLY   A 1 217 ? 21.12745  16.41093  38.86238  1.000 32.22204  ? 579 GLY   A C    1 
ATOM   3173 O O    . GLY   A 1 217 ? 20.38404  17.14182  39.52724  1.000 32.05444  ? 579 GLY   A O    1 
ATOM   3174 H H    . GLY   A 1 217 ? 23.11814  14.27302  38.47257  1.000 38.91630  ? 579 GLY   A H    1 
ATOM   3175 H HA2  . GLY   A 1 217 ? 21.60643  14.74363  39.90395  1.000 35.94493  ? 579 GLY   A HA2  1 
ATOM   3176 H HA3  . GLY   A 1 217 ? 22.43435  16.01094  40.35442  1.000 35.94493  ? 579 GLY   A HA3  1 
ATOM   3177 N N    . PHE   A 1 218 ? 21.13134  16.39479  37.51297  1.000 31.89817  ? 580 PHE   A N    1 
ATOM   3178 C CA   . PHE   A 1 218 ? 20.20077  17.12014  36.65995  1.000 30.87591  ? 580 PHE   A CA   1 
ATOM   3179 C C    . PHE   A 1 218 ? 19.56714  16.16930  35.65003  1.000 30.03335  ? 580 PHE   A C    1 
ATOM   3180 O O    . PHE   A 1 218 ? 20.16025  15.15447  35.28827  1.000 26.91454  ? 580 PHE   A O    1 
ATOM   3181 C CB   . PHE   A 1 218 ? 20.91241  18.25799  35.90078  1.000 31.16795  ? 580 PHE   A CB   1 
ATOM   3182 C CG   . PHE   A 1 218 ? 21.66686  19.15305  36.79501  1.000 42.67585  ? 580 PHE   A CG   1 
ATOM   3183 C CD1  . PHE   A 1 218 ? 20.99517  20.06461  37.59006  1.000 44.19727  ? 580 PHE   A CD1  1 
ATOM   3184 C CD2  . PHE   A 1 218 ? 23.04680  19.04383  36.90990  1.000 42.93882  ? 580 PHE   A CD2  1 
ATOM   3185 C CE1  . PHE   A 1 218 ? 21.68689  20.86949  38.47023  1.000 43.06635  ? 580 PHE   A CE1  1 
ATOM   3186 C CE2  . PHE   A 1 218 ? 23.74437  19.85887  37.78846  1.000 45.14128  ? 580 PHE   A CE2  1 
ATOM   3187 C CZ   . PHE   A 1 218 ? 23.05083  20.77033  38.56834  1.000 45.70249  ? 580 PHE   A CZ   1 
ATOM   3188 H H    . PHE   A 1 218 ? 21.70044  15.94170  37.05423  1.000 38.28985  ? 580 PHE   A H    1 
ATOM   3189 H HA   . PHE   A 1 218 ? 19.49488  17.49731  37.20800  1.000 37.06315  ? 580 PHE   A HA   1 
ATOM   3190 H HB2  . PHE   A 1 218 ? 21.53592  17.87240  35.26559  1.000 37.41359  ? 580 PHE   A HB2  1 
ATOM   3191 H HB3  . PHE   A 1 218 ? 20.24893  18.78939  35.43355  1.000 37.41359  ? 580 PHE   A HB3  1 
ATOM   3192 H HD1  . PHE   A 1 218 ? 20.06977  20.13500  37.53031  1.000 53.04878  ? 580 PHE   A HD1  1 
ATOM   3193 H HD2  . PHE   A 1 218 ? 23.50562  18.42034  36.39450  1.000 51.53864  ? 580 PHE   A HD2  1 
ATOM   3194 H HE1  . PHE   A 1 218 ? 21.22711  21.48121  38.99872  1.000 51.69168  ? 580 PHE   A HE1  1 
ATOM   3195 H HE2  . PHE   A 1 218 ? 24.66983  19.79430  37.85371  1.000 54.18160  ? 580 PHE   A HE2  1 
ATOM   3196 H HZ   . PHE   A 1 218 ? 23.51294  21.31769  39.16143  1.000 54.85504  ? 580 PHE   A HZ   1 
ATOM   3197 N N    . LEU   A 1 219 ? 18.37331  16.51870  35.16978  1.000 28.13958  ? 581 LEU   A N    1 
ATOM   3198 C CA   . LEU   A 1 219 ? 17.76615  15.73303  34.09997  1.000 28.63852  ? 581 LEU   A CA   1 
ATOM   3199 C C    . LEU   A 1 219 ? 18.68851  15.74433  32.88995  1.000 29.39849  ? 581 LEU   A C    1 
ATOM   3200 O O    . LEU   A 1 219 ? 19.52085  16.63787  32.72886  1.000 29.64444  ? 581 LEU   A O    1 
ATOM   3201 C CB   . LEU   A 1 219 ? 16.38682  16.26747  33.71669  1.000 27.80066  ? 581 LEU   A CB   1 
ATOM   3202 C CG   . LEU   A 1 219 ? 15.32273  16.33588  34.80478  1.000 30.63135  ? 581 LEU   A CG   1 
ATOM   3203 C CD1  . LEU   A 1 219 ? 14.15527  17.16611  34.34112  1.000 34.81100  ? 581 LEU   A CD1  1 
ATOM   3204 C CD2  . LEU   A 1 219 ? 14.83394  14.94798  35.12691  1.000 31.39075  ? 581 LEU   A CD2  1 
ATOM   3205 H H    . LEU   A 1 219 ? 17.90723  17.18908  35.43990  1.000 33.77955  ? 581 LEU   A H    1 
ATOM   3206 H HA   . LEU   A 1 219 ? 17.63484  14.82092  34.40281  1.000 34.37828  ? 581 LEU   A HA   1 
ATOM   3207 H HB2  . LEU   A 1 219 ? 16.50270  17.17061  33.38230  1.000 33.37285  ? 581 LEU   A HB2  1 
ATOM   3208 H HB3  . LEU   A 1 219 ? 16.03353  15.69710  33.01613  1.000 33.37285  ? 581 LEU   A HB3  1 
ATOM   3209 H HG   . LEU   A 1 219 ? 15.70648  16.74018  35.59862  1.000 36.76967  ? 581 LEU   A HG   1 
ATOM   3210 H HD11 . LEU   A 1 219 ? 13.45286  17.12400  35.00877  1.000 41.78525  ? 581 LEU   A HD11 1 
ATOM   3211 H HD12 . LEU   A 1 219 ? 14.44676  18.08397  34.22510  1.000 41.78525  ? 581 LEU   A HD12 1 
ATOM   3212 H HD13 . LEU   A 1 219 ? 13.83161  16.81273  33.49775  1.000 41.78525  ? 581 LEU   A HD13 1 
ATOM   3213 H HD21 . LEU   A 1 219 ? 14.19467  14.99928  35.85465  1.000 37.68095  ? 581 LEU   A HD21 1 
ATOM   3214 H HD22 . LEU   A 1 219 ? 14.40965  14.57198  34.33982  1.000 37.68095  ? 581 LEU   A HD22 1 
ATOM   3215 H HD23 . LEU   A 1 219 ? 15.59006  14.39974  35.38886  1.000 37.68095  ? 581 LEU   A HD23 1 
ATOM   3216 N N    . ALA   A 1 220 ? 18.59358  14.69938  32.08269  1.000 29.83874  ? 582 ALA   A N    1 
ATOM   3217 C CA   . ALA   A 1 220 ? 19.35815  14.63268  30.85536  1.000 26.79095  ? 582 ALA   A CA   1 
ATOM   3218 C C    . ALA   A 1 220 ? 18.61106  15.33413  29.72854  1.000 27.97598  ? 582 ALA   A C    1 
ATOM   3219 O O    . ALA   A 1 220 ? 17.38585  15.40720  29.71802  1.000 28.72812  ? 582 ALA   A O    1 
ATOM   3220 C CB   . ALA   A 1 220 ? 19.63080  13.18513  30.47148  1.000 24.72048  ? 582 ALA   A CB   1 
ATOM   3221 H H    . ALA   A 1 220 ? 18.09133  14.01628  32.22662  1.000 35.81855  ? 582 ALA   A H    1 
ATOM   3222 H HA   . ALA   A 1 220 ? 20.21082  15.07777  30.98079  1.000 32.16119  ? 582 ALA   A HA   1 
ATOM   3223 H HB1  . ALA   A 1 220 ? 20.14442  13.16796  29.64880  1.000 29.67663  ? 582 ALA   A HB1  1 
ATOM   3224 H HB2  . ALA   A 1 220 ? 20.13261  12.75869  31.18368  1.000 29.67663  ? 582 ALA   A HB2  1 
ATOM   3225 H HB3  . ALA   A 1 220 ? 18.78508  12.72781  30.34302  1.000 29.67663  ? 582 ALA   A HB3  1 
ATOM   3226 N N    . ARG   A 1 221 ? 19.37815  15.85607  28.77582  1.000 31.21164  ? 583 ARG   A N    1 
ATOM   3227 C CA   . ARG   A 1 221 ? 18.77159  16.46022  27.59427  1.000 34.09082  ? 583 ARG   A CA   1 
ATOM   3228 C C    . ARG   A 1 221 ? 18.46977  15.40323  26.54546  1.000 25.46134  ? 583 ARG   A C    1 
ATOM   3229 O O    . ARG   A 1 221 ? 17.49035  15.51292  25.81195  1.000 23.91599  ? 583 ARG   A O    1 
ATOM   3230 C CB   . ARG   A 1 221 ? 19.69574  17.52729  27.00843  1.000 27.49455  ? 583 ARG   A CB   1 
ATOM   3231 C CG   . ARG   A 1 221 ? 19.92195  18.72461  27.92983  1.000 39.32589  ? 583 ARG   A CG   1 
ATOM   3232 C CD   . ARG   A 1 221 ? 18.70787  19.60841  28.01283  1.000 44.19944  ? 583 ARG   A CD   1 
ATOM   3233 N NE   . ARG   A 1 221 ? 18.99823  20.94179  28.53222  1.000 36.31104  ? 583 ARG   A NE   1 
ATOM   3234 C CZ   . ARG   A 1 221 ? 19.14578  22.04109  27.79933  1.000 47.50381  ? 583 ARG   A CZ   1 
ATOM   3235 N NH1  . ARG   A 1 221 ? 19.15214  22.00761  26.47555  1.000 56.95315  ? 583 ARG   A NH1  1 
ATOM   3236 N NH2  . ARG   A 1 221 ? 19.28367  23.20763  28.41237  1.000 42.50314  ? 583 ARG   A NH2  1 
ATOM   3237 H H    . ARG   A 1 221 ? 20.23789  15.87317  28.78861  1.000 37.46602  ? 583 ARG   A H    1 
ATOM   3238 H HA   . ARG   A 1 221 ? 17.94344  16.89435  27.85234  1.000 40.92103  ? 583 ARG   A HA   1 
ATOM   3239 H HB2  . ARG   A 1 221 ? 20.56011  17.12554  26.82849  1.000 33.00551  ? 583 ARG   A HB2  1 
ATOM   3240 H HB3  . ARG   A 1 221 ? 19.30570  17.85827  26.18429  1.000 33.00551  ? 583 ARG   A HB3  1 
ATOM   3241 H HG2  . ARG   A 1 221 ? 20.12638  18.40625  28.82300  1.000 47.20312  ? 583 ARG   A HG2  1 
ATOM   3242 H HG3  . ARG   A 1 221 ? 20.65966  19.25464  27.58961  1.000 47.20312  ? 583 ARG   A HG3  1 
ATOM   3243 H HD2  . ARG   A 1 221 ? 18.33237  19.71063  27.12432  1.000 53.05138  ? 583 ARG   A HD2  1 
ATOM   3244 H HD3  . ARG   A 1 221 ? 18.05787  19.19475  28.60214  1.000 53.05138  ? 583 ARG   A HD3  1 
ATOM   3245 H HE   . ARG   A 1 221 ? 19.08079  21.02286  29.38439  1.000 43.58530  ? 583 ARG   A HE   1 
ATOM   3246 H HH11 . ARG   A 1 221 ? 19.05891  21.25831  26.06391  1.000 68.35584  ? 583 ARG   A HH11 1 
ATOM   3247 H HH12 . ARG   A 1 221 ? 19.24949  22.73518  26.02747  1.000 68.35584  ? 583 ARG   A HH12 1 
ATOM   3248 H HH21 . ARG   A 1 221 ? 19.27686  23.24536  29.27151  1.000 51.01583  ? 583 ARG   A HH21 1 
ATOM   3249 H HH22 . ARG   A 1 221 ? 19.37999  23.92706  27.95111  1.000 51.01583  ? 583 ARG   A HH22 1 
ATOM   3250 N N    . ASN   A 1 222 ? 19.34156  14.41880  26.45800  1.000 26.99610  ? 584 ASN   A N    1 
ATOM   3251 C CA   . ASN   A 1 222 ? 19.30030  13.32505  25.51089  1.000 27.34429  ? 584 ASN   A CA   1 
ATOM   3252 C C    . ASN   A 1 222 ? 19.04844  12.03941  26.28115  1.000 30.77145  ? 584 ASN   A C    1 
ATOM   3253 O O    . ASN   A 1 222 ? 19.43157  11.91167  27.45200  1.000 24.82128  ? 584 ASN   A O    1 
ATOM   3254 C CB   . ASN   A 1 222 ? 20.61416  13.24534  24.73453  1.000 27.12024  ? 584 ASN   A CB   1 
ATOM   3255 C CG   . ASN   A 1 222 ? 20.86964  14.48987  23.88233  1.000 29.51932  ? 584 ASN   A CG   1 
ATOM   3256 O OD1  . ASN   A 1 222 ? 20.54235  14.50896  22.69637  1.000 36.39262  ? 584 ASN   A OD1  1 
ATOM   3257 N ND2  . ASN   A 1 222 ? 21.48214  15.53179  24.48824  1.000 32.70377  ? 584 ASN   A ND2  1 
ATOM   3258 H H    . ASN   A 1 222 ? 20.02242  14.35737  26.97978  1.000 32.40738  ? 584 ASN   A H    1 
ATOM   3259 H HA   . ASN   A 1 222 ? 18.58804  13.44193  24.86288  1.000 32.82520  ? 584 ASN   A HA   1 
ATOM   3260 H HB2  . ASN   A 1 222 ? 21.34805  13.15503  25.36234  1.000 32.55634  ? 584 ASN   A HB2  1 
ATOM   3261 H HB3  . ASN   A 1 222 ? 20.58668  12.47670  24.14348  1.000 32.55634  ? 584 ASN   A HB3  1 
ATOM   3262 H HD21 . ASN   A 1 222 ? 21.64504  16.25116  24.04601  1.000 39.25657  ? 584 ASN   A HD21 1 
ATOM   3263 H HD22 . ASN   A 1 222 ? 21.70886  15.47518  25.31588  1.000 39.25657  ? 584 ASN   A HD22 1 
ATOM   3264 N N    . LEU   A 1 223 ? 18.34034  11.11974  25.63361  1.000 25.43486  ? 585 LEU   A N    1 
ATOM   3265 C CA   . LEU   A 1 223 ? 18.01796  9.83887   26.23974  1.000 26.56141  ? 585 LEU   A CA   1 
ATOM   3266 C C    . LEU   A 1 223 ? 19.30257  9.09235   26.60689  1.000 26.99962  ? 585 LEU   A C    1 
ATOM   3267 O O    . LEU   A 1 223 ? 20.21851  8.98980   25.79258  1.000 24.15869  ? 585 LEU   A O    1 
ATOM   3268 C CB   . LEU   A 1 223 ? 17.15645  9.01241   25.26961  1.000 27.70548  ? 585 LEU   A CB   1 
ATOM   3269 C CG   . LEU   A 1 223 ? 16.63386  7.66470   25.75021  1.000 29.04045  ? 585 LEU   A CG   1 
ATOM   3270 C CD1  . LEU   A 1 223 ? 15.65215  7.87743   26.89090  1.000 27.67297  ? 585 LEU   A CD1  1 
ATOM   3271 C CD2  . LEU   A 1 223 ? 16.00269  6.86523   24.58103  1.000 32.36617  ? 585 LEU   A CD2  1 
ATOM   3272 H H    . LEU   A 1 223 ? 18.03325  11.21542  24.83602  1.000 30.53389  ? 585 LEU   A H    1 
ATOM   3273 H HA   . LEU   A 1 223 ? 17.50824  9.97257   27.05412  1.000 31.88574  ? 585 LEU   A HA   1 
ATOM   3274 H HB2  . LEU   A 1 223 ? 16.38021  9.54568   25.03727  1.000 33.25863  ? 585 LEU   A HB2  1 
ATOM   3275 H HB3  . LEU   A 1 223 ? 17.68874  8.83868   24.47753  1.000 33.25863  ? 585 LEU   A HB3  1 
ATOM   3276 H HG   . LEU   A 1 223 ? 17.36792  7.12624   26.08506  1.000 34.86059  ? 585 LEU   A HG   1 
ATOM   3277 H HD11 . LEU   A 1 223 ? 15.21977  7.03392   27.09688  1.000 33.21962  ? 585 LEU   A HD11 1 
ATOM   3278 H HD12 . LEU   A 1 223 ? 16.13559  8.19969   27.66765  1.000 33.21962  ? 585 LEU   A HD12 1 
ATOM   3279 H HD13 . LEU   A 1 223 ? 14.98918  8.53130   26.61918  1.000 33.21962  ? 585 LEU   A HD13 1 
ATOM   3280 H HD21 . LEU   A 1 223 ? 15.68018  6.01469   24.91789  1.000 38.85145  ? 585 LEU   A HD21 1 
ATOM   3281 H HD22 . LEU   A 1 223 ? 15.26535  7.37561   24.21125  1.000 38.85145  ? 585 LEU   A HD22 1 
ATOM   3282 H HD23 . LEU   A 1 223 ? 16.67693  6.71693   23.89962  1.000 38.85145  ? 585 LEU   A HD23 1 
ATOM   3283 N N    . MET   A 1 224 ? 19.36952  8.61364   27.84547  1.000 22.59393  ? 586 MET   A N    1 
ATOM   3284 C CA   . MET   A 1 224 ? 20.50479  7.88600   28.40991  1.000 23.80646  ? 586 MET   A CA   1 
ATOM   3285 C C    . MET   A 1 224 ? 20.05262  6.46910   28.71476  1.000 27.36929  ? 586 MET   A C    1 
ATOM   3286 O O    . MET   A 1 224 ? 18.85500  6.22260   28.84673  1.000 25.84436  ? 586 MET   A O    1 
ATOM   3287 C CB   . MET   A 1 224 ? 21.01820  8.57261   29.68415  1.000 24.16219  ? 586 MET   A CB   1 
ATOM   3288 C CG   . MET   A 1 224 ? 21.49799  10.00656  29.47097  1.000 31.36345  ? 586 MET   A CG   1 
ATOM   3289 S SD   . MET   A 1 224 ? 23.01660  9.98855   28.59098  1.000 32.64567  ? 586 MET   A SD   1 
ATOM   3290 C CE   . MET   A 1 224 ? 23.43906  11.71635  28.41191  1.000 31.36017  ? 586 MET   A CE   1 
ATOM   3291 H H    . MET   A 1 224 ? 18.73054  8.70270   28.41413  1.000 27.12477  ? 586 MET   A H    1 
ATOM   3292 H HA   . MET   A 1 224 ? 21.24293  7.86305   27.78100  1.000 28.57981  ? 586 MET   A HA   1 
ATOM   3293 H HB2  . MET   A 1 224 ? 20.29937  8.59628   30.33502  1.000 29.00669  ? 586 MET   A HB2  1 
ATOM   3294 H HB3  . MET   A 1 224 ? 21.76487  8.06102   30.03296  1.000 29.00669  ? 586 MET   A HB3  1 
ATOM   3295 H HG2  . MET   A 1 224 ? 20.84153  10.49963  28.95441  1.000 37.64819  ? 586 MET   A HG2  1 
ATOM   3296 H HG3  . MET   A 1 224 ? 21.63714  10.43773  30.32866  1.000 37.64819  ? 586 MET   A HG3  1 
ATOM   3297 H HE1  . MET   A 1 224 ? 24.26630  11.78888  27.91060  1.000 37.64426  ? 586 MET   A HE1  1 
ATOM   3298 H HE2  . MET   A 1 224 ? 22.72407  12.16876  27.93754  1.000 37.64426  ? 586 MET   A HE2  1 
ATOM   3299 H HE3  . MET   A 1 224 ? 23.55070  12.10709  29.29268  1.000 37.64426  ? 586 MET   A HE3  1 
ATOM   3300 N N    . TYR   A 1 225 ? 21.00183  5.52869   28.83187  1.000 30.44627  ? 587 TYR   A N    1 
ATOM   3301 C CA   . TYR   A 1 225 ? 20.65703  4.17686   29.26339  1.000 27.80434  ? 587 TYR   A CA   1 
ATOM   3302 C C    . TYR   A 1 225 ? 21.81302  3.52243   30.02792  1.000 23.21239  ? 587 TYR   A C    1 
ATOM   3303 O O    . TYR   A 1 225 ? 22.96916  3.90791   29.88477  1.000 25.39901  ? 587 TYR   A O    1 
ATOM   3304 C CB   . TYR   A 1 225 ? 20.24527  3.30377   28.06819  1.000 25.16302  ? 587 TYR   A CB   1 
ATOM   3305 C CG   . TYR   A 1 225 ? 21.37953  2.89605   27.15666  1.000 28.68452  ? 587 TYR   A CG   1 
ATOM   3306 C CD1  . TYR   A 1 225 ? 21.86399  3.76662   26.20898  1.000 26.43620  ? 587 TYR   A CD1  1 
ATOM   3307 C CD2  . TYR   A 1 225 ? 21.95333  1.62733   27.23551  1.000 34.75606  ? 587 TYR   A CD2  1 
ATOM   3308 C CE1  . TYR   A 1 225 ? 22.88272  3.41667   25.37259  1.000 31.90005  ? 587 TYR   A CE1  1 
ATOM   3309 C CE2  . TYR   A 1 225 ? 22.98990  1.26453   26.38921  1.000 33.29237  ? 587 TYR   A CE2  1 
ATOM   3310 C CZ   . TYR   A 1 225 ? 23.45083  2.17553   25.46703  1.000 39.17285  ? 587 TYR   A CZ   1 
ATOM   3311 O OH   . TYR   A 1 225 ? 24.44869  1.84727   24.60119  1.000 41.04947  ? 587 TYR   A OH   1 
ATOM   3312 H H    . TYR   A 1 225 ? 21.83715  5.65207   28.66872  1.000 36.54758  ? 587 TYR   A H    1 
ATOM   3313 H HA   . TYR   A 1 225 ? 19.91739  4.24157   29.88760  1.000 33.37727  ? 587 TYR   A HA   1 
ATOM   3314 H HB2  . TYR   A 1 225 ? 19.83772  2.49137   28.40702  1.000 30.20767  ? 587 TYR   A HB2  1 
ATOM   3315 H HB3  . TYR   A 1 225 ? 19.60484  3.79789   27.53284  1.000 30.20767  ? 587 TYR   A HB3  1 
ATOM   3316 H HD1  . TYR   A 1 225 ? 21.48803  4.61417   26.13667  1.000 31.73549  ? 587 TYR   A HD1  1 
ATOM   3317 H HD2  . TYR   A 1 225 ? 21.63712  1.01785   27.86277  1.000 41.71933  ? 587 TYR   A HD2  1 
ATOM   3318 H HE1  . TYR   A 1 225 ? 23.19148  4.02200   24.73765  1.000 38.29211  ? 587 TYR   A HE1  1 
ATOM   3319 H HE2  . TYR   A 1 225 ? 23.36849  0.41686   26.44417  1.000 39.96289  ? 587 TYR   A HE2  1 
ATOM   3320 H HH   . TYR   A 1 225 ? 24.81448  1.13070   24.84272  1.000 49.27141  ? 587 TYR   A HH   1 
ATOM   3321 N N    . VAL   A 1 226 ? 21.46322  2.53476   30.87560  1.000 27.86931  ? 588 VAL   A N    1 
ATOM   3322 C CA   . VAL   A 1 226 ? 22.39571  1.70826   31.63998  1.000 26.32570  ? 588 VAL   A CA   1 
ATOM   3323 C C    . VAL   A 1 226 ? 22.01386  0.24126   31.53337  1.000 29.49781  ? 588 VAL   A C    1 
ATOM   3324 O O    . VAL   A 1 226 ? 20.83012  -0.08995  31.61674  1.000 27.99847  ? 588 VAL   A O    1 
ATOM   3325 C CB   . VAL   A 1 226 ? 22.43039  2.01445   33.15921  1.000 34.84386  ? 588 VAL   A CB   1 
ATOM   3326 C CG1  . VAL   A 1 226 ? 23.44652  3.05418   33.49882  1.000 32.47467  ? 588 VAL   A CG1  1 
ATOM   3327 C CG2  . VAL   A 1 226 ? 21.02801  2.30681   33.72289  1.000 28.06979  ? 588 VAL   A CG2  1 
ATOM   3328 H H    . VAL   A 1 226 ? 20.64447  2.31952   31.02699  1.000 33.45523  ? 588 VAL   A H    1 
ATOM   3329 H HA   . VAL   A 1 226 ? 23.25998  1.88628   31.23718  1.000 31.60290  ? 588 VAL   A HA   1 
ATOM   3330 H HB   . VAL   A 1 226 ? 22.72544  1.21229   33.61790  1.000 41.82468  ? 588 VAL   A HB   1 
ATOM   3331 H HG11 . VAL   A 1 226 ? 23.62201  3.02468   34.45235  1.000 38.98166  ? 588 VAL   A HG11 1 
ATOM   3332 H HG12 . VAL   A 1 226 ? 24.26209  2.87135   33.00657  1.000 38.98166  ? 588 VAL   A HG12 1 
ATOM   3333 H HG13 . VAL   A 1 226 ? 23.10027  3.92630   33.25303  1.000 38.98166  ? 588 VAL   A HG13 1 
ATOM   3334 H HG21 . VAL   A 1 226 ? 21.11843  2.72472   34.59356  1.000 33.69580  ? 588 VAL   A HG21 1 
ATOM   3335 H HG22 . VAL   A 1 226 ? 20.56196  2.90339   33.11643  1.000 33.69580  ? 588 VAL   A HG22 1 
ATOM   3336 H HG23 . VAL   A 1 226 ? 20.54059  1.47225   33.80556  1.000 33.69580  ? 588 VAL   A HG23 1 
ATOM   3337 N N    . ASP   A 1 227 ? 23.01869  -0.64138  31.49262  1.000 29.25786  ? 589 ASP   A N    1 
ATOM   3338 C CA   . ASP   A 1 227 ? 22.80433  -2.06859  31.69767  1.000 27.84815  ? 589 ASP   A CA   1 
ATOM   3339 C C    . ASP   A 1 227 ? 23.03070  -2.34872  33.17076  1.000 32.54692  ? 589 ASP   A C    1 
ATOM   3340 O O    . ASP   A 1 227 ? 24.05396  -1.93774  33.73082  1.000 30.04098  ? 589 ASP   A O    1 
ATOM   3341 C CB   . ASP   A 1 227 ? 23.74905  -2.90595  30.82729  1.000 25.54337  ? 589 ASP   A CB   1 
ATOM   3342 C CG   . ASP   A 1 227 ? 23.47259  -2.73503  29.34400  1.000 33.67190  ? 589 ASP   A CG   1 
ATOM   3343 O OD1  . ASP   A 1 227 ? 22.32361  -2.41760  28.98843  1.000 30.76807  ? 589 ASP   A OD1  1 
ATOM   3344 O OD2  . ASP   A 1 227 ? 24.40492  -2.87570  28.52377  1.000 36.33995  ? 589 ASP   A OD2  1 
ATOM   3345 H H    . ASP   A 1 227 ? 23.83958  -0.43096  31.34612  1.000 35.12149  ? 589 ASP   A H    1 
ATOM   3346 H HA   . ASP   A 1 227 ? 21.90251  -2.32311  31.44698  1.000 33.42984  ? 589 ASP   A HA   1 
ATOM   3347 H HB2  . ASP   A 1 227 ? 24.66387  -2.63174  30.99705  1.000 30.66410  ? 589 ASP   A HB2  1 
ATOM   3348 H HB3  . ASP   A 1 227 ? 23.63726  -3.84369  31.04874  1.000 30.66410  ? 589 ASP   A HB3  1 
ATOM   3349 N N    . ILE   A 1 228 ? 22.06379  -3.00367  33.80538  1.000 24.36382  ? 590 ILE   A N    1 
ATOM   3350 C CA   . ILE   A 1 228 ? 22.13270  -3.27356  35.23873  1.000 27.81931  ? 590 ILE   A CA   1 
ATOM   3351 C C    . ILE   A 1 228 ? 21.68466  -4.70680  35.51843  1.000 32.35635  ? 590 ILE   A C    1 
ATOM   3352 O O    . ILE   A 1 228 ? 20.78106  -5.20454  34.83437  1.000 29.48036  ? 590 ILE   A O    1 
ATOM   3353 C CB   . ILE   A 1 228 ? 21.28710  -2.26521  36.02665  1.000 28.63887  ? 590 ILE   A CB   1 
ATOM   3354 C CG1  . ILE   A 1 228 ? 19.87775  -2.15319  35.42993  1.000 29.47405  ? 590 ILE   A CG1  1 
ATOM   3355 C CG2  . ILE   A 1 228 ? 21.99470  -0.92030  36.03882  1.000 33.05090  ? 590 ILE   A CG2  1 
ATOM   3356 C CD1  . ILE   A 1 228 ? 19.03352  -1.05568  36.02417  1.000 37.73221  ? 590 ILE   A CD1  1 
ATOM   3357 H H    . ILE   A 1 228 ? 21.35286  -3.30410  33.42601  1.000 29.24864  ? 590 ILE   A H    1 
ATOM   3358 H HA   . ILE   A 1 228 ? 23.05679  -3.19648  35.52337  1.000 33.39523  ? 590 ILE   A HA   1 
ATOM   3359 H HB   . ILE   A 1 228 ? 21.18714  -2.57533  36.94029  1.000 34.37870  ? 590 ILE   A HB   1 
ATOM   3360 H HG12 . ILE   A 1 228 ? 19.95767  -1.97906  34.47904  1.000 35.38091  ? 590 ILE   A HG12 1 
ATOM   3361 H HG13 . ILE   A 1 228 ? 19.41283  -2.99194  35.57569  1.000 35.38091  ? 590 ILE   A HG13 1 
ATOM   3362 H HG21 . ILE   A 1 228 ? 21.58117  -0.35192  36.70728  1.000 39.67313  ? 590 ILE   A HG21 1 
ATOM   3363 H HG22 . ILE   A 1 228 ? 22.93039  -1.05769  36.25449  1.000 39.67313  ? 590 ILE   A HG22 1 
ATOM   3364 H HG23 . ILE   A 1 228 ? 21.91366  -0.51288  35.16227  1.000 39.67313  ? 590 ILE   A HG23 1 
ATOM   3365 H HD11 . ILE   A 1 228 ? 18.10351  -1.21617  35.80007  1.000 45.29071  ? 590 ILE   A HD11 1 
ATOM   3366 H HD12 . ILE   A 1 228 ? 19.14657  -1.05678  36.98756  1.000 45.29071  ? 590 ILE   A HD12 1 
ATOM   3367 H HD13 . ILE   A 1 228 ? 19.31966  -0.20403  35.65851  1.000 45.29071  ? 590 ILE   A HD13 1 
ATOM   3368 N N    . PRO   A 1 229 ? 22.28520  -5.40326  36.49353  1.000 33.22043  ? 591 PRO   A N    1 
ATOM   3369 C CA   . PRO   A 1 229 ? 21.87868  -6.78126  36.78102  1.000 28.25633  ? 591 PRO   A CA   1 
ATOM   3370 C C    . PRO   A 1 229 ? 20.68378  -6.80391  37.71487  1.000 34.11445  ? 591 PRO   A C    1 
ATOM   3371 O O    . PRO   A 1 229 ? 20.52264  -5.92968  38.57152  1.000 30.70476  ? 591 PRO   A O    1 
ATOM   3372 C CB   . PRO   A 1 229 ? 23.10649  -7.36231  37.48470  1.000 29.11070  ? 591 PRO   A CB   1 
ATOM   3373 C CG   . PRO   A 1 229 ? 23.66114  -6.21476  38.23409  1.000 36.71478  ? 591 PRO   A CG   1 
ATOM   3374 C CD   . PRO   A 1 229 ? 23.30046  -4.95303  37.46391  1.000 35.38217  ? 591 PRO   A CD   1 
ATOM   3375 H HA   . PRO   A 1 229 ? 21.69232  -7.27681  35.96825  1.000 33.91965  ? 591 PRO   A HA   1 
ATOM   3376 H HB2  . PRO   A 1 229 ? 22.84172  -8.07801  38.08352  1.000 34.94490  ? 591 PRO   A HB2  1 
ATOM   3377 H HB3  . PRO   A 1 229 ? 23.74115  -7.69463  36.83074  1.000 34.94490  ? 591 PRO   A HB3  1 
ATOM   3378 H HG2  . PRO   A 1 229 ? 23.27078  -6.19213  39.12178  1.000 44.06979  ? 591 PRO   A HG2  1 
ATOM   3379 H HG3  . PRO   A 1 229 ? 24.62454  -6.30824  38.29760  1.000 44.06979  ? 591 PRO   A HG3  1 
ATOM   3380 H HD2  . PRO   A 1 229 ? 22.93106  -4.28235  38.05942  1.000 42.47065  ? 591 PRO   A HD2  1 
ATOM   3381 H HD3  . PRO   A 1 229 ? 24.07806  -4.59769  37.00568  1.000 42.47065  ? 591 PRO   A HD3  1 
ATOM   3382 N N    . ILE   A 1 230 ? 19.85686  -7.83266  37.55991  1.000 30.41063  ? 592 ILE   A N    1 
ATOM   3383 C CA   . ILE   A 1 230 ? 18.80537  -8.08479  38.52565  1.000 28.66255  ? 592 ILE   A CA   1 
ATOM   3384 C C    . ILE   A 1 230 ? 19.44897  -8.48690  39.83572  1.000 28.50251  ? 592 ILE   A C    1 
ATOM   3385 O O    . ILE   A 1 230 ? 20.39539  -9.27606  39.86504  1.000 30.40937  ? 592 ILE   A O    1 
ATOM   3386 C CB   . ILE   A 1 230 ? 17.83039  -9.17250  38.02558  1.000 29.82357  ? 592 ILE   A CB   1 
ATOM   3387 C CG1  . ILE   A 1 230 ? 16.98450  -8.61568  36.88048  1.000 29.81213  ? 592 ILE   A CG1  1 
ATOM   3388 C CG2  . ILE   A 1 230 ? 16.95659  -9.66579  39.20163  1.000 29.44170  ? 592 ILE   A CG2  1 
ATOM   3389 C CD1  . ILE   A 1 230 ? 16.05485  -9.64574  36.20036  1.000 42.02665  ? 592 ILE   A CD1  1 
ATOM   3390 H H    . ILE   A 1 230 ? 19.88642  -8.39290  36.90809  1.000 36.50481  ? 592 ILE   A H    1 
ATOM   3391 H HA   . ILE   A 1 230 ? 18.28691  -7.27479  38.65219  1.000 34.40712  ? 592 ILE   A HA   1 
ATOM   3392 H HB   . ILE   A 1 230 ? 18.32767  -9.93226  37.68444  1.000 35.80034  ? 592 ILE   A HB   1 
ATOM   3393 H HG12 . ILE   A 1 230 ? 16.42533  -7.90376  37.22889  1.000 35.78661  ? 592 ILE   A HG12 1 
ATOM   3394 H HG13 . ILE   A 1 230 ? 17.58031  -8.26640  36.19937  1.000 35.78661  ? 592 ILE   A HG13 1 
ATOM   3395 H HG21 . ILE   A 1 230 ? 16.17909  -10.12449 38.84668  1.000 35.34209  ? 592 ILE   A HG21 1 
ATOM   3396 H HG22 . ILE   A 1 230 ? 17.47788  -10.27356 39.74915  1.000 35.34209  ? 592 ILE   A HG22 1 
ATOM   3397 H HG23 . ILE   A 1 230 ? 16.67731  -8.90162  39.72979  1.000 35.34209  ? 592 ILE   A HG23 1 
ATOM   3398 H HD11 . ILE   A 1 230 ? 15.66137  -9.24289  35.41056  1.000 50.44403  ? 592 ILE   A HD11 1 
ATOM   3399 H HD12 . ILE   A 1 230 ? 16.57609  -10.42445 35.94973  1.000 50.44403  ? 592 ILE   A HD12 1 
ATOM   3400 H HD13 . ILE   A 1 230 ? 15.35710  -9.90141  36.82381  1.000 50.44403  ? 592 ILE   A HD13 1 
ATOM   3401 N N    . VAL   A 1 231 ? 18.90684  -7.98601  40.92209  1.000 34.63063  ? 593 VAL   A N    1 
ATOM   3402 C CA   . VAL   A 1 231 ? 19.41680  -8.22424  42.25867  1.000 29.30495  ? 593 VAL   A CA   1 
ATOM   3403 C C    . VAL   A 1 231 ? 18.55320  -9.27033  42.94454  1.000 37.23759  ? 593 VAL   A C    1 
ATOM   3404 O O    . VAL   A 1 231 ? 17.32171  -9.28430  42.79370  1.000 33.77830  ? 593 VAL   A O    1 
ATOM   3405 C CB   . VAL   A 1 231 ? 19.44425  -6.89371  43.04186  1.000 35.92905  ? 593 VAL   A CB   1 
ATOM   3406 C CG1  . VAL   A 1 231 ? 19.66702  -7.13307  44.50816  1.000 39.89187  ? 593 VAL   A CG1  1 
ATOM   3407 C CG2  . VAL   A 1 231 ? 20.52129  -5.97091  42.44747  1.000 36.89035  ? 593 VAL   A CG2  1 
ATOM   3408 H H    . VAL   A 1 231 ? 18.21057  -7.48129  40.91418  1.000 41.56881  ? 593 VAL   A H    1 
ATOM   3409 H HA   . VAL   A 1 231 ? 20.31665  -8.58415  42.21825  1.000 35.17800  ? 593 VAL   A HA   1 
ATOM   3410 H HB   . VAL   A 1 231 ? 18.58450  -6.45204  42.96026  1.000 43.12692  ? 593 VAL   A HB   1 
ATOM   3411 H HG11 . VAL   A 1 231 ? 19.97864  -6.31125  44.91853  1.000 47.88230  ? 593 VAL   A HG11 1 
ATOM   3412 H HG12 . VAL   A 1 231 ? 18.83018  -7.40876  44.91386  1.000 47.88230  ? 593 VAL   A HG12 1 
ATOM   3413 H HG13 . VAL   A 1 231 ? 20.33273  -7.83015  44.61679  1.000 47.88230  ? 593 VAL   A HG13 1 
ATOM   3414 H HG21 . VAL   A 1 231 ? 20.18156  -5.06263  42.42498  1.000 44.28048  ? 593 VAL   A HG21 1 
ATOM   3415 H HG22 . VAL   A 1 231 ? 21.31525  -6.01344  43.00309  1.000 44.28048  ? 593 VAL   A HG22 1 
ATOM   3416 H HG23 . VAL   A 1 231 ? 20.73057  -6.26816  41.54817  1.000 44.28048  ? 593 VAL   A HG23 1 
ATOM   3417 N N    . ASP   A 1 232 ? 19.20299  -10.15421 43.70102  1.000 38.14710  ? 594 ASP   A N    1 
ATOM   3418 C CA   . ASP   A 1 232 ? 18.47580  -11.14168 44.48659  1.000 39.59643  ? 594 ASP   A CA   1 
ATOM   3419 C C    . ASP   A 1 232 ? 17.40666  -10.47148 45.34530  1.000 38.32293  ? 594 ASP   A C    1 
ATOM   3420 O O    . ASP   A 1 232 ? 17.63004  -9.42495  45.96060  1.000 33.34704  ? 594 ASP   A O    1 
ATOM   3421 C CB   . ASP   A 1 232 ? 19.44863  -11.92175 45.36749  1.000 39.22521  ? 594 ASP   A CB   1 
ATOM   3422 C CG   . ASP   A 1 232 ? 18.74010  -12.78769 46.35693  1.000 46.13727  ? 594 ASP   A CG   1 
ATOM   3423 O OD1  . ASP   A 1 232 ? 18.32792  -13.89149 45.96850  1.000 53.49239  ? 594 ASP   A OD1  1 
ATOM   3424 O OD2  . ASP   A 1 232 ? 18.57972  -12.35979 47.51797  1.000 53.20259  ? 594 ASP   A OD2  1 
ATOM   3425 H H    . ASP   A 1 232 ? 20.05856  -10.20088 43.77462  1.000 45.78858  ? 594 ASP   A H    1 
ATOM   3426 H HA   . ASP   A 1 232 ? 18.03354  -11.76596 43.89029  1.000 47.52777  ? 594 ASP   A HA   1 
ATOM   3427 H HB2  . ASP   A 1 232 ? 19.99977  -12.49050 44.80742  1.000 47.08230  ? 594 ASP   A HB2  1 
ATOM   3428 H HB3  . ASP   A 1 232 ? 20.00656  -11.29707 45.85675  1.000 47.08230  ? 594 ASP   A HB3  1 
ATOM   3429 N N    . HIS   A 1 233 ? 16.22659  -11.08021 45.37822  1.000 37.50440  ? 595 HIS   A N    1 
ATOM   3430 C CA   . HIS   A 1 233 ? 15.08609  -10.38146 45.94284  1.000 34.19486  ? 595 HIS   A CA   1 
ATOM   3431 C C    . HIS   A 1 233 ? 15.17599  -10.24231 47.45083  1.000 34.96203  ? 595 HIS   A C    1 
ATOM   3432 O O    . HIS   A 1 233 ? 14.68365  -9.25320  48.00953  1.000 28.47705  ? 595 HIS   A O    1 
ATOM   3433 C CB   . HIS   A 1 233 ? 13.81066  -11.09720 45.55400  1.000 33.27150  ? 595 HIS   A CB   1 
ATOM   3434 C CG   . HIS   A 1 233 ? 12.60063  -10.22341 45.59416  1.000 34.96480  ? 595 HIS   A CG   1 
ATOM   3435 N ND1  . HIS   A 1 233 ? 11.71633  -10.23301 46.64828  1.000 33.29495  ? 595 HIS   A ND1  1 
ATOM   3436 C CD2  . HIS   A 1 233 ? 12.10825  -9.33969  44.69603  1.000 34.67970  ? 595 HIS   A CD2  1 
ATOM   3437 C CE1  . HIS   A 1 233 ? 10.73345  -9.38704  46.40379  1.000 35.43966  ? 595 HIS   A CE1  1 
ATOM   3438 N NE2  . HIS   A 1 233 ? 10.95259  -8.82807  45.22999  1.000 31.90136  ? 595 HIS   A NE2  1 
ATOM   3439 H H    . HIS   A 1 233 ? 16.06636  -11.87388 45.08836  1.000 45.01734  ? 595 HIS   A H    1 
ATOM   3440 H HA   . HIS   A 1 233 ? 15.06277  -9.48407  45.57535  1.000 41.04588  ? 595 HIS   A HA   1 
ATOM   3441 H HB2  . HIS   A 1 233 ? 13.90423  -11.43352 44.64900  1.000 39.93785  ? 595 HIS   A HB2  1 
ATOM   3442 H HB3  . HIS   A 1 233 ? 13.66564  -11.83374 46.16831  1.000 39.93785  ? 595 HIS   A HB3  1 
ATOM   3443 H HD2  . HIS   A 1 233 ? 12.48204  -9.12062  43.87311  1.000 41.62769  ? 595 HIS   A HD2  1 
ATOM   3444 H HE1  . HIS   A 1 233 ? 10.01068  -9.21482  46.96312  1.000 42.53965  ? 595 HIS   A HE1  1 
ATOM   3445 H HE2  . HIS   A 1 233 ? 10.45090  -8.23676  44.85815  1.000 38.29369  ? 595 HIS   A HE2  1 
ATOM   3446 N N    . GLN   A 1 234 ? 15.75951  -11.22746 48.12815  1.000 37.08139  ? 596 GLN   A N    1 
ATOM   3447 C CA   . GLN   A 1 234 ? 16.00539  -11.09374 49.56057  1.000 39.19727  ? 596 GLN   A CA   1 
ATOM   3448 C C    . GLN   A 1 234 ? 16.91270  -9.91309  49.82150  1.000 33.67613  ? 596 GLN   A C    1 
ATOM   3449 O O    . GLN   A 1 234 ? 16.67957  -9.12812  50.74479  1.000 43.19870  ? 596 GLN   A O    1 
ATOM   3450 C CB   . GLN   A 1 234 ? 16.62123  -12.39255 50.12051  1.000 31.42173  ? 596 GLN   A CB   1 
ATOM   3451 C CG   . GLN   A 1 234 ? 17.48296  -12.22973 51.33956  1.000 48.56380  ? 596 GLN   A CG   1 
ATOM   3452 C CD   . GLN   A 1 234 ? 17.52500  -13.45294 52.20185  1.000 47.32774  ? 596 GLN   A CD   1 
ATOM   3453 O OE1  . GLN   A 1 234 ? 17.60235  -14.58858 51.70900  1.000 45.59606  ? 596 GLN   A OE1  1 
ATOM   3454 N NE2  . GLN   A 1 234 ? 17.56372  -13.22913 53.50438  1.000 47.82729  ? 596 GLN   A NE2  1 
ATOM   3455 H H    . GLN   A 1 234 ? 16.01930  -11.97326 47.78771  1.000 44.50972  ? 596 GLN   A H    1 
ATOM   3456 H HA   . GLN   A 1 234 ? 15.16479  -10.95005 50.02278  1.000 47.04878  ? 596 GLN   A HA   1 
ATOM   3457 H HB2  . GLN   A 1 234 ? 15.89864  -12.99499 50.35681  1.000 37.71814  ? 596 GLN   A HB2  1 
ATOM   3458 H HB3  . GLN   A 1 234 ? 17.17260  -12.79093 49.42901  1.000 37.71814  ? 596 GLN   A HB3  1 
ATOM   3459 H HG2  . GLN   A 1 234 ? 18.39015  -12.03201 51.05883  1.000 58.28862  ? 596 GLN   A HG2  1 
ATOM   3460 H HG3  . GLN   A 1 234 ? 17.13485  -11.49973 51.87511  1.000 58.28862  ? 596 GLN   A HG3  1 
ATOM   3461 H HE21 . GLN   A 1 234 ? 17.56354  -12.42237 53.80225  1.000 57.40480  ? 596 GLN   A HE21 1 
ATOM   3462 H HE22 . GLN   A 1 234 ? 17.58909  -13.89033 54.05373  1.000 57.40480  ? 596 GLN   A HE22 1 
ATOM   3463 N N    . LYS   A 1 235 ? 17.96661  -9.79147  49.02753  1.000 32.98081  ? 597 LYS   A N    1 
ATOM   3464 C CA   . LYS   A 1 235 ? 18.93721  -8.72577  49.21337  1.000 38.04365  ? 597 LYS   A CA   1 
ATOM   3465 C C    . LYS   A 1 235 ? 18.29168  -7.36797  49.00887  1.000 37.23428  ? 597 LYS   A C    1 
ATOM   3466 O O    . LYS   A 1 235 ? 18.61599  -6.39570  49.69987  1.000 41.76304  ? 597 LYS   A O    1 
ATOM   3467 C CB   . LYS   A 1 235 ? 20.08814  -8.93420  48.23359  1.000 45.48645  ? 597 LYS   A CB   1 
ATOM   3468 C CG   . LYS   A 1 235 ? 21.47234  -8.61635  48.77136  1.000 48.33343  ? 597 LYS   A CG   1 
ATOM   3469 C CD   . LYS   A 1 235 ? 22.54505  -9.17218  47.84633  1.000 59.44727  ? 597 LYS   A CD   1 
ATOM   3470 C CE   . LYS   A 1 235 ? 22.50183  -8.50965  46.47600  1.000 57.08318  ? 597 LYS   A CE   1 
ATOM   3471 N NZ   . LYS   A 1 235 ? 23.85785  -8.08878  46.02413  1.000 65.97214  ? 597 LYS   A NZ   1 
ATOM   3472 H H    . LYS   A 1 235 ? 18.14457  -10.31582 48.36952  1.000 39.58902  ? 597 LYS   A H    1 
ATOM   3473 H HA   . LYS   A 1 235 ? 19.29113  -8.75092  50.11615  1.000 45.66444  ? 597 LYS   A HA   1 
ATOM   3474 H HB2  . LYS   A 1 235 ? 20.09144  -9.86508  47.96092  1.000 54.59580  ? 597 LYS   A HB2  1 
ATOM   3475 H HB3  . LYS   A 1 235 ? 19.93989  -8.36343  47.46344  1.000 54.59580  ? 597 LYS   A HB3  1 
ATOM   3476 H HG2  . LYS   A 1 235 ? 21.58457  -7.65476  48.83181  1.000 58.01216  ? 597 LYS   A HG2  1 
ATOM   3477 H HG3  . LYS   A 1 235 ? 21.58098  -9.01875  49.64724  1.000 58.01216  ? 597 LYS   A HG3  1 
ATOM   3478 H HD2  . LYS   A 1 235 ? 23.41901  -9.01089  48.23501  1.000 71.34878  ? 597 LYS   A HD2  1 
ATOM   3479 H HD3  . LYS   A 1 235 ? 22.40505  -10.12476 47.72847  1.000 71.34878  ? 597 LYS   A HD3  1 
ATOM   3480 H HE2  . LYS   A 1 235 ? 22.14651  -9.13762  45.82769  1.000 68.51187  ? 597 LYS   A HE2  1 
ATOM   3481 H HE3  . LYS   A 1 235 ? 21.93740  -7.72194  46.51873  1.000 68.51187  ? 597 LYS   A HE3  1 
ATOM   3482 H HZ1  . LYS   A 1 235 ? 23.80672  -7.70862  45.22103  1.000 79.17862  ? 597 LYS   A HZ1  1 
ATOM   3483 H HZ2  . LYS   A 1 235 ? 24.20235  -7.50350  46.59934  1.000 79.17862  ? 597 LYS   A HZ2  1 
ATOM   3484 H HZ3  . LYS   A 1 235 ? 24.39557  -8.79628  45.97508  1.000 79.17862  ? 597 LYS   A HZ3  1 
ATOM   3485 N N    . CYS   A 1 236 ? 17.34973  -7.28529  48.07711  1.000 34.91337  ? 598 CYS   A N    1 
ATOM   3486 C CA   . CYS   A 1 236 ? 16.68235  -6.02425  47.83352  1.000 28.74762  ? 598 CYS   A CA   1 
ATOM   3487 C C    . CYS   A 1 236 ? 15.68374  -5.71169  48.93040  1.000 32.83564  ? 598 CYS   A C    1 
ATOM   3488 O O    . CYS   A 1 236 ? 15.63889  -4.58680  49.43576  1.000 32.53184  ? 598 CYS   A O    1 
ATOM   3489 C CB   . CYS   A 1 236 ? 16.00752  -6.06584  46.48809  1.000 33.83092  ? 598 CYS   A CB   1 
ATOM   3490 S SG   . CYS   A 1 236 ? 15.25219  -4.49080  46.07377  1.000 40.65103  ? 598 CYS   A SG   1 
ATOM   3491 H H    . CYS   A 1 236 ? 17.08555  -7.93696  47.58200  1.000 41.90810  ? 598 CYS   A H    1 
ATOM   3492 H HA   . CYS   A 1 236 ? 17.33825  -5.30974  47.82066  1.000 34.50919  ? 598 CYS   A HA   1 
ATOM   3493 H HB2  . CYS   A 1 236 ? 16.66533  -6.27683  45.80716  1.000 40.60916  ? 598 CYS   A HB2  1 
ATOM   3494 H HB3  . CYS   A 1 236 ? 15.31318  -6.74308  46.49976  1.000 40.60916  ? 598 CYS   A HB3  1 
ATOM   3495 N N    . THR   A 1 237 ? 14.87487  -6.70037  49.30046  1.000 30.12649  ? 599 THR   A N    1 
ATOM   3496 C CA   . THR   A 1 237 ? 13.96382  -6.55862  50.42678  1.000 28.63909  ? 599 THR   A CA   1 
ATOM   3497 C C    . THR   A 1 237 ? 14.69154  -6.03906  51.65813  1.000 37.03036  ? 599 THR   A C    1 
ATOM   3498 O O    . THR   A 1 237 ? 14.22503  -5.10266  52.31612  1.000 37.50720  ? 599 THR   A O    1 
ATOM   3499 C CB   . THR   A 1 237 ? 13.31302  -7.91752  50.71086  1.000 33.70431  ? 599 THR   A CB   1 
ATOM   3500 O OG1  . THR   A 1 237 ? 12.52967  -8.33711  49.57823  1.000 39.98966  ? 599 THR   A OG1  1 
ATOM   3501 C CG2  . THR   A 1 237 ? 12.45401  -7.85369  51.93695  1.000 43.50644  ? 599 THR   A CG2  1 
ATOM   3502 H H    . THR   A 1 237 ? 14.83449  -7.46727  48.91338  1.000 36.16385  ? 599 THR   A H    1 
ATOM   3503 H HA   . THR   A 1 237 ? 13.26611  -5.92104  50.20860  1.000 34.37896  ? 599 THR   A HA   1 
ATOM   3504 H HB   . THR   A 1 237 ? 14.00731  -8.57586  50.87038  1.000 40.45722  ? 599 THR   A HB   1 
ATOM   3505 H HG1  . THR   A 1 237 ? 13.02583  -8.44114  48.90845  1.000 47.99964  ? 599 THR   A HG1  1 
ATOM   3506 H HG21 . THR   A 1 237 ? 11.80477  -8.57427  51.92504  1.000 52.21978  ? 599 THR   A HG21 1 
ATOM   3507 H HG22 . THR   A 1 237 ? 13.00354  -7.93819  52.73180  1.000 52.21978  ? 599 THR   A HG22 1 
ATOM   3508 H HG23 . THR   A 1 237 ? 11.98316  -7.00622  51.96840  1.000 52.21978  ? 599 THR   A HG23 1 
ATOM   3509 N N    . ALA   A 1 238 ? 15.87160  -6.59296  51.94143  1.000 35.76715  ? 600 ALA   A N    1 
ATOM   3510 C CA   . ALA   A 1 238 ? 16.61150  -6.22018  53.14322  1.000 44.28507  ? 600 ALA   A CA   1 
ATOM   3511 C C    . ALA   A 1 238 ? 17.11578  -4.78471  53.06499  1.000 42.10598  ? 600 ALA   A C    1 
ATOM   3512 O O    . ALA   A 1 238 ? 17.03717  -4.04098  54.04946  1.000 47.48833  ? 600 ALA   A O    1 
ATOM   3513 C CB   . ALA   A 1 238 ? 17.78864  -7.19102  53.35968  1.000 38.07530  ? 600 ALA   A CB   1 
ATOM   3514 H H    . ALA   A 1 238 ? 16.26351  -7.18460  51.45566  1.000 42.93264  ? 600 ALA   A H    1 
ATOM   3515 H HA   . ALA   A 1 238 ? 16.01645  -6.28779  53.90626  1.000 53.15413  ? 600 ALA   A HA   1 
ATOM   3516 H HB1  . ALA   A 1 238 ? 18.26069  -6.93955  54.16889  1.000 45.70241  ? 600 ALA   A HB1  1 
ATOM   3517 H HB2  . ALA   A 1 238 ? 17.44237  -8.09304  53.44548  1.000 45.70241  ? 600 ALA   A HB2  1 
ATOM   3518 H HB3  . ALA   A 1 238 ? 18.38650  -7.13730  52.59772  1.000 45.70241  ? 600 ALA   A HB3  1 
ATOM   3519 N N    . ALA   A 1 239 ? 17.63893  -4.37731  51.90391  1.000 39.67609  ? 601 ALA   A N    1 
ATOM   3520 C CA   . ALA   A 1 239 ? 18.19038  -3.03428  51.74564  1.000 39.97621  ? 601 ALA   A CA   1 
ATOM   3521 C C    . ALA   A 1 239 ? 17.15979  -1.94467  52.03173  1.000 46.08116  ? 601 ALA   A C    1 
ATOM   3522 O O    . ALA   A 1 239 ? 17.53789  -0.82570  52.37943  1.000 42.68908  ? 601 ALA   A O    1 
ATOM   3523 C CB   . ALA   A 1 239 ? 18.74164  -2.86897  50.32669  1.000 39.95264  ? 601 ALA   A CB   1 
ATOM   3524 H H    . ALA   A 1 239 ? 17.68552  -4.86080  51.19422  1.000 47.62337  ? 601 ALA   A H    1 
ATOM   3525 H HA   . ALA   A 1 239 ? 18.92078  -2.92034  52.37368  1.000 47.98351  ? 601 ALA   A HA   1 
ATOM   3526 H HB1  . ALA   A 1 239 ? 19.07768  -1.96512  50.22175  1.000 47.95522  ? 601 ALA   A HB1  1 
ATOM   3527 H HB2  . ALA   A 1 239 ? 19.45971  -3.50673  50.19057  1.000 47.95522  ? 601 ALA   A HB2  1 
ATOM   3528 H HB3  . ALA   A 1 239 ? 18.02859  -3.03279  49.68980  1.000 47.95522  ? 601 ALA   A HB3  1 
ATOM   3529 N N    . TYR   A 1 240 ? 15.86649  -2.24376  51.90463  1.000 41.95755  ? 602 TYR   A N    1 
ATOM   3530 C CA   . TYR   A 1 240 ? 14.81327  -1.26852  52.10895  1.000 38.55543  ? 602 TYR   A CA   1 
ATOM   3531 C C    . TYR   A 1 240 ? 14.01677  -1.51931  53.37853  1.000 39.82590  ? 602 TYR   A C    1 
ATOM   3532 O O    . TYR   A 1 240 ? 13.05184  -0.79915  53.64186  1.000 38.06050  ? 602 TYR   A O    1 
ATOM   3533 C CB   . TYR   A 1 240 ? 13.91220  -1.25519  50.86735  1.000 35.80024  ? 602 TYR   A CB   1 
ATOM   3534 C CG   . TYR   A 1 240 ? 14.59264  -0.53869  49.72894  1.000 30.15628  ? 602 TYR   A CG   1 
ATOM   3535 C CD1  . TYR   A 1 240 ? 14.75446  0.82629   49.76311  1.000 36.91516  ? 602 TYR   A CD1  1 
ATOM   3536 C CD2  . TYR   A 1 240 ? 15.13986  -1.23281  48.66066  1.000 27.24410  ? 602 TYR   A CD2  1 
ATOM   3537 C CE1  . TYR   A 1 240 ? 15.40017  1.49511   48.73789  1.000 43.54520  ? 602 TYR   A CE1  1 
ATOM   3538 C CE2  . TYR   A 1 240 ? 15.78850  -0.57439  47.64126  1.000 30.73573  ? 602 TYR   A CE2  1 
ATOM   3539 C CZ   . TYR   A 1 240 ? 15.92013  0.78157   47.68187  1.000 34.34135  ? 602 TYR   A CZ   1 
ATOM   3540 O OH   . TYR   A 1 240 ? 16.55843  1.45282   46.66063  1.000 41.35119  ? 602 TYR   A OH   1 
ATOM   3541 H H    . TYR   A 1 240 ? 15.57414  -3.02508  51.69565  1.000 50.36112  ? 602 TYR   A H    1 
ATOM   3542 H HA   . TYR   A 1 240 ? 15.18953  -0.37960  52.20452  1.000 46.27857  ? 602 TYR   A HA   1 
ATOM   3543 H HB2  . TYR   A 1 240 ? 13.72534  -2.16644  50.59237  1.000 42.97234  ? 602 TYR   A HB2  1 
ATOM   3544 H HB3  . TYR   A 1 240 ? 13.08385  -0.79413  51.07266  1.000 42.97234  ? 602 TYR   A HB3  1 
ATOM   3545 H HD1  . TYR   A 1 240 ? 14.42461  1.30799   50.48703  1.000 44.31025  ? 602 TYR   A HD1  1 
ATOM   3546 H HD2  . TYR   A 1 240 ? 15.06725  -2.15955  48.63261  1.000 32.70497  ? 602 TYR   A HD2  1 
ATOM   3547 H HE1  . TYR   A 1 240 ? 15.48228  2.42116   48.76230  1.000 52.26629  ? 602 TYR   A HE1  1 
ATOM   3548 H HE2  . TYR   A 1 240 ? 16.13690  -1.05438  46.92493  1.000 36.89493  ? 602 TYR   A HE2  1 
ATOM   3549 H HH   . TYR   A 1 240 ? 17.04198  0.92127   46.22562  1.000 49.63348  ? 602 TYR   A HH   1 
ATOM   3550 N N    . GLU   A 1 241 ? 14.40533  -2.51612  54.17909  1.000 46.03786  ? 603 GLU   A N    1 
ATOM   3551 C CA   . GLU   A 1 241 ? 13.83417  -2.72946  55.51487  1.000 46.91356  ? 603 GLU   A CA   1 
ATOM   3552 C C    . GLU   A 1 241 ? 14.61284  -1.83859  56.49686  1.000 47.29330  ? 603 GLU   A C    1 
ATOM   3553 O O    . GLU   A 1 241 ? 15.52736  -2.26531  57.20171  1.000 45.99316  ? 603 GLU   A O    1 
ATOM   3554 C CB   . GLU   A 1 241 ? 13.88167  -4.21844  55.87288  1.000 44.57103  ? 603 GLU   A CB   1 
ATOM   3555 C CG   . GLU   A 1 241 ? 12.58913  -4.84770  56.41440  1.000 61.97374  ? 603 GLU   A CG   1 
ATOM   3556 C CD   . GLU   A 1 241 ? 11.33326  -4.59477  55.58404  1.000 56.68476  ? 603 GLU   A CD   1 
ATOM   3557 O OE1  . GLU   A 1 241 ? 10.22636  -4.51319  56.17033  1.000 53.56103  ? 603 GLU   A OE1  1 
ATOM   3558 O OE2  . GLU   A 1 241 ? 11.44853  -4.49149  54.34526  1.000 63.68715  ? 603 GLU   A OE2  1 
ATOM   3559 H H    . GLU   A 1 241 ? 15.00815  -3.09230  53.96878  1.000 55.25749  ? 603 GLU   A H    1 
ATOM   3560 H HA   . GLU   A 1 241 ? 12.90376  -2.45636  55.54056  1.000 56.30833  ? 603 GLU   A HA   1 
ATOM   3561 H HB2  . GLU   A 1 241 ? 14.12131  -4.71099  55.07234  1.000 53.49729  ? 603 GLU   A HB2  1 
ATOM   3562 H HB3  . GLU   A 1 241 ? 14.56169  -4.34077  56.55369  1.000 53.49729  ? 603 GLU   A HB3  1 
ATOM   3563 H HG2  . GLU   A 1 241 ? 12.71413  -5.80846  56.46150  1.000 74.38054  ? 603 GLU   A HG2  1 
ATOM   3564 H HG3  . GLU   A 1 241 ? 12.42437  -4.49071  57.30114  1.000 74.38054  ? 603 GLU   A HG3  1 
ATOM   3565 N N    . LYS   A 1 242 ? 14.25580  -0.54184  56.51099  1.000 47.51329  ? 604 LYS   A N    1 
ATOM   3566 C CA   . LYS   A 1 242 ? 14.91375  0.44640   57.36882  1.000 42.83898  ? 604 LYS   A CA   1 
ATOM   3567 C C    . LYS   A 1 242 ? 14.16974  1.75969   57.22903  1.000 43.59901  ? 604 LYS   A C    1 
ATOM   3568 O O    . LYS   A 1 242 ? 13.55188  1.99740   56.18357  1.000 37.93511  ? 604 LYS   A O    1 
ATOM   3569 C CB   . LYS   A 1 242 ? 16.38580  0.68187   57.00966  1.000 42.74262  ? 604 LYS   A CB   1 
ATOM   3570 C CG   . LYS   A 1 242 ? 16.68795  0.94130   55.52220  1.000 48.19075  ? 604 LYS   A CG   1 
ATOM   3571 C CD   . LYS   A 1 242 ? 18.12994  0.59299   55.09774  1.000 52.21348  ? 604 LYS   A CD   1 
ATOM   3572 C CE   . LYS   A 1 242 ? 18.50231  -0.86996  55.40719  1.000 48.40945  ? 604 LYS   A CE   1 
ATOM   3573 N NZ   . LYS   A 1 242 ? 19.62749  -1.37002  54.59742  1.000 47.91048  ? 604 LYS   A NZ   1 
ATOM   3574 H H    . LYS   A 1 242 ? 13.62772  -0.21101  56.02553  1.000 57.02800  ? 604 LYS   A H    1 
ATOM   3575 H HA   . LYS   A 1 242 ? 14.89373  0.11368   58.27975  1.000 51.41883  ? 604 LYS   A HA   1 
ATOM   3576 H HB2  . LYS   A 1 242 ? 16.69774  1.45594   57.50404  1.000 51.30320  ? 604 LYS   A HB2  1 
ATOM   3577 H HB3  . LYS   A 1 242 ? 16.89046  -0.10419  57.27108  1.000 51.30320  ? 604 LYS   A HB3  1 
ATOM   3578 H HG2  . LYS   A 1 242 ? 16.08612  0.40319   54.98449  1.000 57.84096  ? 604 LYS   A HG2  1 
ATOM   3579 H HG3  . LYS   A 1 242 ? 16.54704  1.88281   55.33618  1.000 57.84096  ? 604 LYS   A HG3  1 
ATOM   3580 H HD2  . LYS   A 1 242 ? 18.22078  0.72994   54.14176  1.000 62.66823  ? 604 LYS   A HD2  1 
ATOM   3581 H HD3  . LYS   A 1 242 ? 18.74849  1.16753   55.57544  1.000 62.66823  ? 604 LYS   A HD3  1 
ATOM   3582 H HE2  . LYS   A 1 242 ? 18.75460  -0.93896  56.34126  1.000 58.10339  ? 604 LYS   A HE2  1 
ATOM   3583 H HE3  . LYS   A 1 242 ? 17.73375  -1.43417  55.22859  1.000 58.10339  ? 604 LYS   A HE3  1 
ATOM   3584 H HZ1  . LYS   A 1 242 ? 19.81018  -2.21276  54.81770  1.000 57.50462  ? 604 LYS   A HZ1  1 
ATOM   3585 H HZ2  . LYS   A 1 242 ? 19.41900  -1.33617  53.73284  1.000 57.50462  ? 604 LYS   A HZ2  1 
ATOM   3586 H HZ3  . LYS   A 1 242 ? 20.35052  -0.87100  54.73993  1.000 57.50462  ? 604 LYS   A HZ3  1 
ATOM   3587 N N    . PRO   A 1 243 ? 14.19425  2.64707   58.21915  1.000 49.98708  ? 605 PRO   A N    1 
ATOM   3588 C CA   . PRO   A 1 243 ? 13.59123  3.95480   58.01017  1.000 47.17668  ? 605 PRO   A CA   1 
ATOM   3589 C C    . PRO   A 1 243 ? 14.33543  4.67972   56.90297  1.000 38.08889  ? 605 PRO   A C    1 
ATOM   3590 O O    . PRO   A 1 243 ? 15.51213  4.38202   56.63533  1.000 44.11581  ? 605 PRO   A O    1 
ATOM   3591 C CB   . PRO   A 1 243 ? 13.76019  4.65211   59.36910  1.000 51.12302  ? 605 PRO   A CB   1 
ATOM   3592 C CG   . PRO   A 1 243 ? 13.96152  3.54667   60.34599  1.000 55.26508  ? 605 PRO   A CG   1 
ATOM   3593 C CD   . PRO   A 1 243 ? 14.73910  2.51631   59.58238  1.000 49.54289  ? 605 PRO   A CD   1 
ATOM   3594 H HA   . PRO   A 1 243 ? 12.64620  3.88942   57.80146  1.000 56.62407  ? 605 PRO   A HA   1 
ATOM   3595 H HB2  . PRO   A 1 243 ? 14.53185  5.23937   59.34532  1.000 61.35968  ? 605 PRO   A HB2  1 
ATOM   3596 H HB3  . PRO   A 1 243 ? 12.96213  5.16133   59.58053  1.000 61.35968  ? 605 PRO   A HB3  1 
ATOM   3597 H HG2  . PRO   A 1 243 ? 14.46319  3.86588   61.11237  1.000 66.33015  ? 605 PRO   A HG2  1 
ATOM   3598 H HG3  . PRO   A 1 243 ? 13.10436  3.19527   60.63355  1.000 66.33015  ? 605 PRO   A HG3  1 
ATOM   3599 H HD2  . PRO   A 1 243 ? 15.68844  2.71483   59.59806  1.000 59.46352  ? 605 PRO   A HD2  1 
ATOM   3600 H HD3  . PRO   A 1 243 ? 14.58015  1.62744   59.93672  1.000 59.46352  ? 605 PRO   A HD3  1 
ATOM   3601 N N    . PRO   A 1 244 ? 13.67473  5.60196   56.21008  1.000 41.91019  ? 606 PRO   A N    1 
ATOM   3602 C CA   . PRO   A 1 244 ? 12.28944  6.06944   56.34118  1.000 38.75771  ? 606 PRO   A CA   1 
ATOM   3603 C C    . PRO   A 1 244 ? 11.27808  5.24017   55.54966  1.000 39.51617  ? 606 PRO   A C    1 
ATOM   3604 O O    . PRO   A 1 244 ? 10.12704  5.63989   55.39848  1.000 41.28080  ? 606 PRO   A O    1 
ATOM   3605 C CB   . PRO   A 1 244 ? 12.38018  7.49253   55.80390  1.000 35.13882  ? 606 PRO   A CB   1 
ATOM   3606 C CG   . PRO   A 1 244 ? 13.34928  7.36457   54.69914  1.000 40.81256  ? 606 PRO   A CG   1 
ATOM   3607 C CD   . PRO   A 1 244 ? 14.39767  6.38743   55.19251  1.000 40.17911  ? 606 PRO   A CD   1 
ATOM   3608 H HA   . PRO   A 1 244 ? 12.03317  6.06547   57.27670  1.000 46.52131  ? 606 PRO   A HA   1 
ATOM   3609 H HB2  . PRO   A 1 244 ? 11.51403  7.78962   55.48387  1.000 42.17864  ? 606 PRO   A HB2  1 
ATOM   3610 H HB3  . PRO   A 1 244 ? 12.70383  8.09446   56.49226  1.000 42.17864  ? 606 PRO   A HB3  1 
ATOM   3611 H HG2  . PRO   A 1 244 ? 12.90315  7.02227   53.90876  1.000 48.98713  ? 606 PRO   A HG2  1 
ATOM   3612 H HG3  . PRO   A 1 244 ? 13.74577  8.22898   54.50813  1.000 48.98713  ? 606 PRO   A HG3  1 
ATOM   3613 H HD2  . PRO   A 1 244 ? 14.70560  5.81743   54.47058  1.000 48.22698  ? 606 PRO   A HD2  1 
ATOM   3614 H HD3  . PRO   A 1 244 ? 15.14874  6.85701   55.58786  1.000 48.22698  ? 606 PRO   A HD3  1 
ATOM   3615 N N    . TYR   A 1 245 ? 11.66689  4.08210   55.06652  1.000 42.04886  ? 607 TYR   A N    1 
ATOM   3616 C CA   . TYR   A 1 245 ? 10.82776  3.32910   54.13716  1.000 42.35175  ? 607 TYR   A CA   1 
ATOM   3617 C C    . TYR   A 1 245 ? 9.68005   2.63283   54.86782  1.000 43.02909  ? 607 TYR   A C    1 
ATOM   3618 O O    . TYR   A 1 245 ? 9.84910   2.15460   55.99377  1.000 36.36405  ? 607 TYR   A O    1 
ATOM   3619 C CB   . TYR   A 1 245 ? 11.67085  2.30359   53.39190  1.000 36.08687  ? 607 TYR   A CB   1 
ATOM   3620 C CG   . TYR   A 1 245 ? 12.80477  2.94986   52.62019  1.000 40.04175  ? 607 TYR   A CG   1 
ATOM   3621 C CD1  . TYR   A 1 245 ? 12.55420  3.69988   51.47810  1.000 40.74230  ? 607 TYR   A CD1  1 
ATOM   3622 C CD2  . TYR   A 1 245 ? 14.12524  2.81450   53.03332  1.000 39.21307  ? 607 TYR   A CD2  1 
ATOM   3623 C CE1  . TYR   A 1 245 ? 13.58810  4.29665   50.77002  1.000 38.62457  ? 607 TYR   A CE1  1 
ATOM   3624 C CE2  . TYR   A 1 245 ? 15.15290  3.39939   52.32486  1.000 37.93560  ? 607 TYR   A CE2  1 
ATOM   3625 C CZ   . TYR   A 1 245 ? 14.86488  4.14798   51.19486  1.000 34.63391  ? 607 TYR   A CZ   1 
ATOM   3626 O OH   . TYR   A 1 245 ? 15.86708  4.74234   50.46649  1.000 43.75474  ? 607 TYR   A OH   1 
ATOM   3627 H H    . TYR   A 1 245 ? 12.41379  3.70004   55.25566  1.000 50.47069  ? 607 TYR   A H    1 
ATOM   3628 H HA   . TYR   A 1 245 ? 10.43264  3.93807   53.49379  1.000 50.83416  ? 607 TYR   A HA   1 
ATOM   3629 H HB2  . TYR   A 1 245 ? 12.05428  1.68225   54.03051  1.000 43.31630  ? 607 TYR   A HB2  1 
ATOM   3630 H HB3  . TYR   A 1 245 ? 11.10842  1.82671   52.76170  1.000 43.31630  ? 607 TYR   A HB3  1 
ATOM   3631 H HD1  . TYR   A 1 245 ? 11.67849  3.80395   51.18280  1.000 48.90281  ? 607 TYR   A HD1  1 
ATOM   3632 H HD2  . TYR   A 1 245 ? 14.31799  2.32235   53.79853  1.000 47.06773  ? 607 TYR   A HD2  1 
ATOM   3633 H HE1  . TYR   A 1 245 ? 13.40463  4.79625   50.00737  1.000 46.36154  ? 607 TYR   A HE1  1 
ATOM   3634 H HE2  . TYR   A 1 245 ? 16.03372  3.29231   52.60342  1.000 45.53478  ? 607 TYR   A HE2  1 
ATOM   3635 H HH   . TYR   A 1 245 ? 16.61339  4.57194   50.81231  1.000 52.51774  ? 607 TYR   A HH   1 
ATOM   3636 N N    . PRO   A 1 246 ? 8.49696   2.54239   54.25739  1.000 35.13959  ? 608 PRO   A N    1 
ATOM   3637 C CA   . PRO   A 1 246 ? 7.42588   1.80475   54.92652  1.000 40.97262  ? 608 PRO   A CA   1 
ATOM   3638 C C    . PRO   A 1 246 ? 7.76766   0.32838   55.06355  1.000 39.41492  ? 608 PRO   A C    1 
ATOM   3639 O O    . PRO   A 1 246 ? 8.63682   -0.23623  54.38398  1.000 33.33603  ? 608 PRO   A O    1 
ATOM   3640 C CB   . PRO   A 1 246 ? 6.19389   2.03385   54.03369  1.000 41.08380  ? 608 PRO   A CB   1 
ATOM   3641 C CG   . PRO   A 1 246 ? 6.70632   2.41141   52.71606  1.000 48.89919  ? 608 PRO   A CG   1 
ATOM   3642 C CD   . PRO   A 1 246 ? 8.05233   3.08691   52.96103  1.000 45.41675  ? 608 PRO   A CD   1 
ATOM   3643 H HA   . PRO   A 1 246 ? 7.24816   2.17880   55.80368  1.000 49.17919  ? 608 PRO   A HA   1 
ATOM   3644 H HB2  . PRO   A 1 246 ? 5.67624   1.21541   53.97812  1.000 49.31261  ? 608 PRO   A HB2  1 
ATOM   3645 H HB3  . PRO   A 1 246 ? 5.65034   2.74552   54.40649  1.000 49.31261  ? 608 PRO   A HB3  1 
ATOM   3646 H HG2  . PRO   A 1 246 ? 6.81607   1.61765   52.16944  1.000 58.69109  ? 608 PRO   A HG2  1 
ATOM   3647 H HG3  . PRO   A 1 246 ? 6.08791   3.02505   52.28953  1.000 58.69109  ? 608 PRO   A HG3  1 
ATOM   3648 H HD2  . PRO   A 1 246 ? 8.68241   2.85854   52.25979  1.000 54.51216  ? 608 PRO   A HD2  1 
ATOM   3649 H HD3  . PRO   A 1 246 ? 7.94760   4.04988   53.01223  1.000 54.51216  ? 608 PRO   A HD3  1 
ATOM   3650 N N    . ARG   A 1 247 ? 7.11057   -0.27324  56.03722  1.000 42.78361  ? 609 ARG   A N    1 
ATOM   3651 C CA   . ARG   A 1 247 ? 7.22479   -1.70211  56.26049  1.000 46.56689  ? 609 ARG   A CA   1 
ATOM   3652 C C    . ARG   A 1 247 ? 6.83521   -2.44414  54.99256  1.000 38.21706  ? 609 ARG   A C    1 
ATOM   3653 O O    . ARG   A 1 247 ? 5.78442   -2.17567  54.41807  1.000 38.28366  ? 609 ARG   A O    1 
ATOM   3654 C CB   . ARG   A 1 247 ? 6.29932   -2.10528  57.40310  1.000 49.35617  ? 609 ARG   A CB   1 
ATOM   3655 C CG   . ARG   A 1 247 ? 6.85428   -3.12225  58.35562  1.000 51.97028  ? 609 ARG   A CG   1 
ATOM   3656 C CD   . ARG   A 1 247 ? 6.03727   -3.10785  59.64229  1.000 53.02765  ? 609 ARG   A CD   1 
ATOM   3657 N NE   . ARG   A 1 247 ? 6.89217   -2.79220  60.77905  1.000 53.13949  ? 609 ARG   A NE   1 
ATOM   3658 C CZ   . ARG   A 1 247 ? 6.56091   -2.01433  61.80429  1.000 53.63553  ? 609 ARG   A CZ   1 
ATOM   3659 N NH1  . ARG   A 1 247 ? 5.36433   -1.45365  61.90308  1.000 50.82244  ? 609 ARG   A NH1  1 
ATOM   3660 N NH2  . ARG   A 1 247 ? 7.45486   -1.80429  62.76524  1.000 54.65165  ? 609 ARG   A NH2  1 
ATOM   3661 H H    . ARG   A 1 247 ? 6.58598   0.12617   56.58938  1.000 51.35238  ? 609 ARG   A H    1 
ATOM   3662 H HA   . ARG   A 1 247 ? 8.13563   -1.93741  56.49693  1.000 55.89232  ? 609 ARG   A HA   1 
ATOM   3663 H HB2  . ARG   A 1 247 ? 6.08815   -1.31153  57.91910  1.000 59.23946  ? 609 ARG   A HB2  1 
ATOM   3664 H HB3  . ARG   A 1 247 ? 5.48913   -2.47857  57.02211  1.000 59.23946  ? 609 ARG   A HB3  1 
ATOM   3665 H HG2  . ARG   A 1 247 ? 6.80207   -4.00662  57.96058  1.000 62.37639  ? 609 ARG   A HG2  1 
ATOM   3666 H HG3  . ARG   A 1 247 ? 7.77624   -2.90715  58.56685  1.000 62.37639  ? 609 ARG   A HG3  1 
ATOM   3667 H HD2  . ARG   A 1 247 ? 5.34272   -2.43362  59.57972  1.000 63.64524  ? 609 ARG   A HD2  1 
ATOM   3668 H HD3  . ARG   A 1 247 ? 5.64002   -3.98105  59.78582  1.000 63.64524  ? 609 ARG   A HD3  1 
ATOM   3669 H HE   . ARG   A 1 247 ? 7.67902   -3.13920  60.78726  1.000 63.77944  ? 609 ARG   A HE   1 
ATOM   3670 H HH11 . ARG   A 1 247 ? 4.77437   -1.58882  61.29212  1.000 60.99898  ? 609 ARG   A HH11 1 
ATOM   3671 H HH12 . ARG   A 1 247 ? 5.17771   -0.95460  62.57815  1.000 60.99898  ? 609 ARG   A HH12 1 
ATOM   3672 H HH21 . ARG   A 1 247 ? 8.23207   -2.16925  62.71677  1.000 65.59403  ? 609 ARG   A HH21 1 
ATOM   3673 H HH22 . ARG   A 1 247 ? 7.25605   -1.30342  63.43547  1.000 65.59403  ? 609 ARG   A HH22 1 
ATOM   3674 N N    . GLY   A 1 248 ? 7.69690   -3.34861  54.54335  1.000 46.25826  ? 610 GLY   A N    1 
ATOM   3675 C CA   . GLY   A 1 248 ? 7.37806   -4.15610  53.38052  1.000 49.39546  ? 610 GLY   A CA   1 
ATOM   3676 C C    . GLY   A 1 248 ? 7.32269   -3.38681  52.07806  1.000 35.74661  ? 610 GLY   A C    1 
ATOM   3677 O O    . GLY   A 1 248 ? 6.43824   -3.63464  51.26287  1.000 33.46691  ? 610 GLY   A O    1 
ATOM   3678 H H    . GLY   A 1 248 ? 8.46574   -3.51082  54.89286  1.000 55.52196  ? 610 GLY   A H    1 
ATOM   3679 H HA2  . GLY   A 1 248 ? 8.05029   -4.84922  53.28780  1.000 59.28661  ? 610 GLY   A HA2  1 
ATOM   3680 H HA3  . GLY   A 1 248 ? 6.51241   -4.57196  53.51694  1.000 59.28661  ? 610 GLY   A HA3  1 
ATOM   3681 N N    . SER   A 1 249 ? 8.26800   -2.48531  51.85244  1.000 32.41606  ? 611 SER   A N    1 
ATOM   3682 C CA   . SER   A 1 249 ? 8.20363   -1.64959  50.65621  1.000 33.15990  ? 611 SER   A CA   1 
ATOM   3683 C C    . SER   A 1 249 ? 8.44583   -2.47189  49.39898  1.000 26.79926  ? 611 SER   A C    1 
ATOM   3684 O O    . SER   A 1 249 ? 7.88510   -2.17610  48.34532  1.000 29.43163  ? 611 SER   A O    1 
ATOM   3685 C CB   . SER   A 1 249 ? 9.23905   -0.53033  50.75406  1.000 33.86350  ? 611 SER   A CB   1 
ATOM   3686 O OG   . SER   A 1 249 ? 8.96442   0.33013   51.83244  1.000 38.53882  ? 611 SER   A OG   1 
ATOM   3687 H H    . SER   A 1 249 ? 8.94426   -2.33784  52.36286  1.000 38.91133  ? 611 SER   A H    1 
ATOM   3688 H HA   . SER   A 1 249 ? 7.32315   -1.24720  50.59509  1.000 39.80393  ? 611 SER   A HA   1 
ATOM   3689 H HB2  . SER   A 1 249 ? 10.11582  -0.92471  50.88306  1.000 40.64825  ? 611 SER   A HB2  1 
ATOM   3690 H HB3  . SER   A 1 249 ? 9.22413   -0.01662  49.93139  1.000 40.64825  ? 611 SER   A HB3  1 
ATOM   3691 H HG   . SER   A 1 249 ? 8.91070   -0.11083  52.54537  1.000 46.25864  ? 611 SER   A HG   1 
ATOM   3692 N N    . VAL   A 1 250 ? 9.27016   -3.50588  49.49234  1.000 26.69222  ? 612 VAL   A N    1 
ATOM   3693 C CA   . VAL   A 1 250 ? 9.55464   -4.38565  48.36837  1.000 31.79319  ? 612 VAL   A CA   1 
ATOM   3694 C C    . VAL   A 1 250 ? 8.64388   -5.59590  48.46907  1.000 33.69495  ? 612 VAL   A C    1 
ATOM   3695 O O    . VAL   A 1 250 ? 8.69374   -6.33207  49.45789  1.000 30.45126  ? 612 VAL   A O    1 
ATOM   3696 C CB   . VAL   A 1 250 ? 11.02333  -4.80725  48.32544  1.000 27.61792  ? 612 VAL   A CB   1 
ATOM   3697 C CG1  . VAL   A 1 250 ? 11.27000  -5.66726  47.07416  1.000 28.93046  ? 612 VAL   A CG1  1 
ATOM   3698 C CG2  . VAL   A 1 250 ? 11.92023  -3.58969  48.26655  1.000 27.07105  ? 612 VAL   A CG2  1 
ATOM   3699 H H    . VAL   A 1 250 ? 9.68610   -3.72292  50.21309  1.000 32.04272  ? 612 VAL   A H    1 
ATOM   3700 H HA   . VAL   A 1 250 ? 9.35363   -3.91394  47.54497  1.000 38.16389  ? 612 VAL   A HA   1 
ATOM   3701 H HB   . VAL   A 1 250 ? 11.23139  -5.31501  49.12531  1.000 33.15356  ? 612 VAL   A HB   1 
ATOM   3702 H HG11 . VAL   A 1 250 ? 12.22546  -5.78461  46.95496  1.000 34.72861  ? 612 VAL   A HG11 1 
ATOM   3703 H HG12 . VAL   A 1 250 ? 10.84327  -6.52996  47.19476  1.000 34.72861  ? 612 VAL   A HG12 1 
ATOM   3704 H HG13 . VAL   A 1 250 ? 10.89318  -5.21688  46.30211  1.000 34.72861  ? 612 VAL   A HG13 1 
ATOM   3705 H HG21 . VAL   A 1 250 ? 12.84006  -3.87974  48.16312  1.000 32.49731  ? 612 VAL   A HG21 1 
ATOM   3706 H HG22 . VAL   A 1 250 ? 11.65922  -3.04147  47.51010  1.000 32.49731  ? 612 VAL   A HG22 1 
ATOM   3707 H HG23 . VAL   A 1 250 ? 11.82290  -3.08565  49.08958  1.000 32.49731  ? 612 VAL   A HG23 1 
ATOM   3708 N N    . THR   A 1 251 ? 7.80711   -5.78041  47.43828  1.000 31.21742  ? 613 THR   A N    1 
ATOM   3709 C CA   . THR   A 1 251 ? 6.81565   -6.84011  47.37940  1.000 33.98594  ? 613 THR   A CA   1 
ATOM   3710 C C    . THR   A 1 251 ? 7.19714   -7.83085  46.29336  1.000 31.15471  ? 613 THR   A C    1 
ATOM   3711 O O    . THR   A 1 251 ? 8.17372   -7.65777  45.55774  1.000 28.46179  ? 613 THR   A O    1 
ATOM   3712 C CB   . THR   A 1 251 ? 5.42404   -6.26404  47.12276  1.000 34.10026  ? 613 THR   A CB   1 
ATOM   3713 O OG1  . THR   A 1 251 ? 5.30829   -5.87969  45.75132  1.000 31.66826  ? 613 THR   A OG1  1 
ATOM   3714 C CG2  . THR   A 1 251 ? 5.14190   -5.05849  48.02190  1.000 29.32400  ? 613 THR   A CG2  1 
ATOM   3715 H H    . THR   A 1 251 ? 7.80237   -5.27976  46.73905  1.000 37.47296  ? 613 THR   A H    1 
ATOM   3716 H HA   . THR   A 1 251 ? 6.79948   -7.30228  48.23206  1.000 40.79519  ? 613 THR   A HA   1 
ATOM   3717 H HB   . THR   A 1 251 ? 4.76057   -6.94166  47.32655  1.000 40.93237  ? 613 THR   A HB   1 
ATOM   3718 H HG1  . THR   A 1 251 ? 6.05412   -5.62547  45.46027  1.000 38.01396  ? 613 THR   A HG1  1 
ATOM   3719 H HG21 . THR   A 1 251 ? 4.20416   -4.81642  47.96769  1.000 35.20086  ? 613 THR   A HG21 1 
ATOM   3720 H HG22 . THR   A 1 251 ? 5.35884   -5.27332  48.94260  1.000 35.20086  ? 613 THR   A HG22 1 
ATOM   3721 H HG23 . THR   A 1 251 ? 5.67920   -4.30159  47.74026  1.000 35.20086  ? 613 THR   A HG23 1 
ATOM   3722 N N    . ALA   A 1 252 ? 6.40784   -8.88953  46.19289  1.000 26.13267  ? 614 ALA   A N    1 
ATOM   3723 C CA   . ALA   A 1 252 ? 6.64120   -9.86383  45.14932  1.000 27.43811  ? 614 ALA   A CA   1 
ATOM   3724 C C    . ALA   A 1 252 ? 6.28399   -9.32989  43.76189  1.000 30.64307  ? 614 ALA   A C    1 
ATOM   3725 O O    . ALA   A 1 252 ? 6.57040   -10.01370 42.76608  1.000 32.93069  ? 614 ALA   A O    1 
ATOM   3726 C CB   . ALA   A 1 252 ? 5.84504   -11.13501 45.46342  1.000 28.51496  ? 614 ALA   A CB   1 
ATOM   3727 H H    . ALA   A 1 252 ? 5.74213   -9.06099  46.70965  1.000 31.37125  ? 614 ALA   A H    1 
ATOM   3728 H HA   . ALA   A 1 252 ? 7.58123   -10.10206 45.12714  1.000 32.93779  ? 614 ALA   A HA   1 
ATOM   3729 H HB1  . ALA   A 1 252 ? 5.95529   -11.76498 44.73412  1.000 34.23001  ? 614 ALA   A HB1  1 
ATOM   3730 H HB2  . ALA   A 1 252 ? 6.17954   -11.52153 46.28781  1.000 34.23001  ? 614 ALA   A HB2  1 
ATOM   3731 H HB3  . ALA   A 1 252 ? 4.90808   -10.90440 45.56252  1.000 34.23001  ? 614 ALA   A HB3  1 
ATOM   3732 N N    . ASN   A 1 253 ? 5.65694   -8.14966  43.66772  1.000 28.29926  ? 615 ASN   A N    1 
ATOM   3733 C CA   . ASN   A 1 253 ? 5.33446   -7.52972  42.38696  1.000 30.44256  ? 615 ASN   A CA   1 
ATOM   3734 C C    . ASN   A 1 253 ? 6.39966   -6.57574  41.93187  1.000 28.15900  ? 615 ASN   A C    1 
ATOM   3735 O O    . ASN   A 1 253 ? 6.11676   -5.69493  41.09840  1.000 27.80490  ? 615 ASN   A O    1 
ATOM   3736 C CB   . ASN   A 1 253 ? 3.99805   -6.78821  42.46693  1.000 24.58162  ? 615 ASN   A CB   1 
ATOM   3737 C CG   . ASN   A 1 253 ? 2.88747   -7.68723  42.85878  1.000 27.09488  ? 615 ASN   A CG   1 
ATOM   3738 O OD1  . ASN   A 1 253 ? 2.75029   -8.77980  42.31432  1.000 28.88735  ? 615 ASN   A OD1  1 
ATOM   3739 N ND2  . ASN   A 1 253 ? 2.11058   -7.27315  43.84234  1.000 32.02434  ? 615 ASN   A ND2  1 
ATOM   3740 H H    . ASN   A 1 253 ? 5.40619   -7.68525  44.34673  1.000 33.97116  ? 615 ASN   A H    1 
ATOM   3741 H HA   . ASN   A 1 253 ? 5.24684   -8.23708  41.72904  1.000 36.54312  ? 615 ASN   A HA   1 
ATOM   3742 H HB2  . ASN   A 1 253 ? 4.06417   -6.08187  43.12845  1.000 29.51000  ? 615 ASN   A HB2  1 
ATOM   3743 H HB3  . ASN   A 1 253 ? 3.79023   -6.41054  41.59798  1.000 29.51000  ? 615 ASN   A HB3  1 
ATOM   3744 H HD21 . ASN   A 1 253 ? 1.45268   -7.76075  44.10505  1.000 38.44126  ? 615 ASN   A HD21 1 
ATOM   3745 H HD22 . ASN   A 1 253 ? 2.26232   -6.51577  44.22042  1.000 38.44126  ? 615 ASN   A HD22 1 
ATOM   3746 N N    . MET   A 1 254 ? 7.59353   -6.68049  42.51610  1.000 26.26515  ? 616 MET   A N    1 
ATOM   3747 C CA   . MET   A 1 254 ? 8.71274   -5.81830  42.19802  1.000 22.61165  ? 616 MET   A CA   1 
ATOM   3748 C C    . MET   A 1 254 ? 9.94159   -6.68341  41.95390  1.000 26.69795  ? 616 MET   A C    1 
ATOM   3749 O O    . MET   A 1 254 ? 10.08059  -7.75528  42.53131  1.000 27.87887  ? 616 MET   A O    1 
ATOM   3750 C CB   . MET   A 1 254 ? 8.98728   -4.79664  43.32870  1.000 27.68147  ? 616 MET   A CB   1 
ATOM   3751 C CG   . MET   A 1 254 ? 7.83275   -3.84656  43.60596  1.000 27.07900  ? 616 MET   A CG   1 
ATOM   3752 S SD   . MET   A 1 254 ? 7.92256   -3.07652  45.22930  1.000 26.29046  ? 616 MET   A SD   1 
ATOM   3753 C CE   . MET   A 1 254 ? 6.19269   -2.68244  45.48957  1.000 28.07792  ? 616 MET   A CE   1 
ATOM   3754 H H    . MET   A 1 254 ? 7.77829   -7.26524  43.11904  1.000 31.53024  ? 616 MET   A H    1 
ATOM   3755 H HA   . MET   A 1 254 ? 8.51851   -5.30863  41.39589  1.000 27.14604  ? 616 MET   A HA   1 
ATOM   3756 H HB2  . MET   A 1 254 ? 9.17117   -5.28279  44.14768  1.000 33.22982  ? 616 MET   A HB2  1 
ATOM   3757 H HB3  . MET   A 1 254 ? 9.75667   -4.26015  43.08148  1.000 33.22982  ? 616 MET   A HB3  1 
ATOM   3758 H HG2  . MET   A 1 254 ? 7.83966   -3.14085  42.94052  1.000 32.50685  ? 616 MET   A HG2  1 
ATOM   3759 H HG3  . MET   A 1 254 ? 6.99980   -4.34117  43.55637  1.000 32.50685  ? 616 MET   A HG3  1 
ATOM   3760 H HE1  . MET   A 1 254 ? 6.08969   -2.27499  46.36380  1.000 33.70555  ? 616 MET   A HE1  1 
ATOM   3761 H HE2  . MET   A 1 254 ? 5.90239   -2.06463  44.80042  1.000 33.70555  ? 616 MET   A HE2  1 
ATOM   3762 H HE3  . MET   A 1 254 ? 5.67204   -3.49948  45.44201  1.000 33.70555  ? 616 MET   A HE3  1 
ATOM   3763 N N    . LEU   A 1 255 ? 10.79339  -6.22199  41.05632  1.000 21.99506  ? 617 LEU   A N    1 
ATOM   3764 C CA   . LEU   A 1 255 ? 12.12093  -6.76182  40.84467  1.000 24.59042  ? 617 LEU   A CA   1 
ATOM   3765 C C    . LEU   A 1 255 ? 13.12865  -5.63228  41.03795  1.000 28.61040  ? 617 LEU   A C    1 
ATOM   3766 O O    . LEU   A 1 255 ? 12.85239  -4.46489  40.71939  1.000 31.53686  ? 617 LEU   A O    1 
ATOM   3767 C CB   . LEU   A 1 255 ? 12.23533  -7.40957  39.47669  1.000 32.94001  ? 617 LEU   A CB   1 
ATOM   3768 C CG   . LEU   A 1 255 ? 12.67071  -6.69953  38.21038  1.000 32.09996  ? 617 LEU   A CG   1 
ATOM   3769 C CD1  . LEU   A 1 255 ? 13.14251  -7.65464  37.14582  1.000 40.68833  ? 617 LEU   A CD1  1 
ATOM   3770 C CD2  . LEU   A 1 255 ? 11.46993  -5.95303  37.68156  1.000 43.55808  ? 617 LEU   A CD2  1 
ATOM   3771 H H    . LEU   A 1 255 ? 10.61542  -5.56377  40.53223  1.000 26.40612  ? 617 LEU   A H    1 
ATOM   3772 H HA   . LEU   A 1 255 ? 12.32949  -7.45604  41.48923  1.000 29.52056  ? 617 LEU   A HA   1 
ATOM   3773 H HB2  . LEU   A 1 255 ? 12.86582  -8.13947  39.57979  1.000 39.54006  ? 617 LEU   A HB2  1 
ATOM   3774 H HB3  . LEU   A 1 255 ? 11.35364  -7.75903  39.27319  1.000 39.54006  ? 617 LEU   A HB3  1 
ATOM   3775 H HG   . LEU   A 1 255 ? 13.41336  -6.11018  38.41539  1.000 38.53200  ? 617 LEU   A HG   1 
ATOM   3776 H HD11 . LEU   A 1 255 ? 13.41775  -7.14754  36.36608  1.000 48.83806  ? 617 LEU   A HD11 1 
ATOM   3777 H HD12 . LEU   A 1 255 ? 13.89197  -8.16556  37.48959  1.000 48.83806  ? 617 LEU   A HD12 1 
ATOM   3778 H HD13 . LEU   A 1 255 ? 12.41461  -8.25166  36.91209  1.000 48.83806  ? 617 LEU   A HD13 1 
ATOM   3779 H HD21 . LEU   A 1 255 ? 11.73616  -5.43626  36.90505  1.000 52.28174  ? 617 LEU   A HD21 1 
ATOM   3780 H HD22 . LEU   A 1 255 ? 10.78424  -6.59286  37.43385  1.000 52.28174  ? 617 LEU   A HD22 1 
ATOM   3781 H HD23 . LEU   A 1 255 ? 11.13577  -5.36148  38.37388  1.000 52.28174  ? 617 LEU   A HD23 1 
ATOM   3782 N N    . CYS   A 1 256 ? 14.26918  -5.97479  41.58983  1.000 26.42010  ? 618 CYS   A N    1 
ATOM   3783 C CA   . CYS   A 1 256 ? 15.31620  -5.00410  41.85374  1.000 26.12489  ? 618 CYS   A CA   1 
ATOM   3784 C C    . CYS   A 1 256 ? 16.47681  -5.20248  40.90249  1.000 29.35627  ? 618 CYS   A C    1 
ATOM   3785 O O    . CYS   A 1 256 ? 16.74976  -6.31108  40.42900  1.000 27.40461  ? 618 CYS   A O    1 
ATOM   3786 C CB   . CYS   A 1 256 ? 15.77367  -5.12697  43.28786  1.000 31.71155  ? 618 CYS   A CB   1 
ATOM   3787 S SG   . CYS   A 1 256 ? 14.34509  -5.02606  44.37132  1.000 32.91460  ? 618 CYS   A SG   1 
ATOM   3788 H H    . CYS   A 1 256 ? 14.46845  -6.77721  41.82651  1.000 31.71617  ? 618 CYS   A H    1 
ATOM   3789 H HA   . CYS   A 1 256 ? 14.98640  -4.10340  41.70926  1.000 31.36192  ? 618 CYS   A HA   1 
ATOM   3790 H HB2  . CYS   A 1 256 ? 16.21179  -5.98195  43.42187  1.000 38.06592  ? 618 CYS   A HB2  1 
ATOM   3791 H HB3  . CYS   A 1 256 ? 16.38409  -4.40420  43.50210  1.000 38.06592  ? 618 CYS   A HB3  1 
ATOM   3792 N N    . ALA   A 1 257 ? 17.15544  -4.10171  40.63100  1.000 28.35705  ? 619 ALA   A N    1 
ATOM   3793 C CA   . ALA   A 1 257 ? 18.20884  -4.10328  39.63828  1.000 30.23908  ? 619 ALA   A CA   1 
ATOM   3794 C C    . ALA   A 1 257 ? 19.14103  -2.95064  39.94119  1.000 28.58140  ? 619 ALA   A C    1 
ATOM   3795 O O    . ALA   A 1 257 ? 18.68995  -1.82136  40.16353  1.000 35.03641  ? 619 ALA   A O    1 
ATOM   3796 C CB   . ALA   A 1 257 ? 17.62911  -3.97804  38.23337  1.000 31.35583  ? 619 ALA   A CB   1 
ATOM   3797 H H    . ALA   A 1 257 ? 17.02367  -3.34072  41.00932  1.000 34.04051  ? 619 ALA   A H    1 
ATOM   3798 H HA   . ALA   A 1 257 ? 18.71428  -4.92994  39.68372  1.000 36.29895  ? 619 ALA   A HA   1 
ATOM   3799 H HB1  . ALA   A 1 257 ? 18.35674  -3.95577  37.59232  1.000 37.63905  ? 619 ALA   A HB1  1 
ATOM   3800 H HB2  . ALA   A 1 257 ? 17.05738  -4.74186  38.05842  1.000 37.63905  ? 619 ALA   A HB2  1 
ATOM   3801 H HB3  . ALA   A 1 257 ? 17.11304  -3.15868  38.17658  1.000 37.63905  ? 619 ALA   A HB3  1 
ATOM   3802 N N    . GLY   A 1 258 ? 20.43117  -3.22587  39.92685  1.000 32.51945  ? 620 GLY   A N    1 
ATOM   3803 C CA   . GLY   A 1 258 ? 21.40591  -2.24372  40.36099  1.000 29.95801  ? 620 GLY   A CA   1 
ATOM   3804 C C    . GLY   A 1 258 ? 22.63078  -2.93002  40.91551  1.000 34.98733  ? 620 GLY   A C    1 
ATOM   3805 O O    . GLY   A 1 258 ? 22.76317  -4.15564  40.86469  1.000 28.62555  ? 620 GLY   A O    1 
ATOM   3806 H H    . GLY   A 1 258 ? 20.76834  -3.97422  39.67019  1.000 39.03539  ? 620 GLY   A H    1 
ATOM   3807 H HA2  . GLY   A 1 258 ? 21.67007  -1.68779  39.61129  1.000 35.96167  ? 620 GLY   A HA2  1 
ATOM   3808 H HA3  . GLY   A 1 258 ? 21.02184  -1.68106  41.05150  1.000 35.96167  ? 620 GLY   A HA3  1 
ATOM   3809 N N    . LEU   A 1 259 ? 23.51298  -2.10939  41.47869  1.000 30.44254  ? 621 LEU   A N    1 
ATOM   3810 C CA   . LEU   A 1 259 ? 24.86108  -2.51587  41.82217  1.000 33.52166  ? 621 LEU   A CA   1 
ATOM   3811 C C    . LEU   A 1 259 ? 25.07388  -2.41148  43.31654  1.000 38.20411  ? 621 LEU   A C    1 
ATOM   3812 O O    . LEU   A 1 259 ? 24.67750  -1.42146  43.94011  1.000 36.77860  ? 621 LEU   A O    1 
ATOM   3813 C CB   . LEU   A 1 259 ? 25.91317  -1.63858  41.14354  1.000 35.89754  ? 621 LEU   A CB   1 
ATOM   3814 C CG   . LEU   A 1 259 ? 25.86762  -1.40853  39.64545  1.000 36.00074  ? 621 LEU   A CG   1 
ATOM   3815 C CD1  . LEU   A 1 259 ? 27.10144  -0.69163  39.15290  1.000 35.87599  ? 621 LEU   A CD1  1 
ATOM   3816 C CD2  . LEU   A 1 259 ? 25.65975  -2.67560  38.96473  1.000 38.90050  ? 621 LEU   A CD2  1 
ATOM   3817 H H    . LEU   A 1 259 ? 23.34363  -1.28940  41.67500  1.000 36.54311  ? 621 LEU   A H    1 
ATOM   3818 H HA   . LEU   A 1 259 ? 24.97545  -3.43608  41.53749  1.000 40.23805  ? 621 LEU   A HA   1 
ATOM   3819 H HB2  . LEU   A 1 259 ? 25.85850  -0.76030  41.55163  1.000 43.08910  ? 621 LEU   A HB2  1 
ATOM   3820 H HB3  . LEU   A 1 259 ? 26.77834  -2.03668  41.32766  1.000 43.08910  ? 621 LEU   A HB3  1 
ATOM   3821 H HG   . LEU   A 1 259 ? 25.12213  -0.82642  39.43032  1.000 43.21294  ? 621 LEU   A HG   1 
ATOM   3822 H HD11 . LEU   A 1 259 ? 27.15337  -0.77880  38.18823  1.000 43.06324  ? 621 LEU   A HD11 1 
ATOM   3823 H HD12 . LEU   A 1 259 ? 27.04125  0.24506   39.39762  1.000 43.06324  ? 621 LEU   A HD12 1 
ATOM   3824 H HD13 . LEU   A 1 259 ? 27.88402  -1.09122  39.56375  1.000 43.06324  ? 621 LEU   A HD13 1 
ATOM   3825 H HD21 . LEU   A 1 259 ? 25.99130  -2.60398  38.05597  1.000 46.69265  ? 621 LEU   A HD21 1 
ATOM   3826 H HD22 . LEU   A 1 259 ? 26.14143  -3.37148  39.43869  1.000 46.69265  ? 621 LEU   A HD22 1 
ATOM   3827 H HD23 . LEU   A 1 259 ? 24.71100  -2.87735  38.95576  1.000 46.69265  ? 621 LEU   A HD23 1 
ATOM   3828 N N    . GLU   A 1 260 ? 25.74989  -3.41353  43.87899  1.000 41.24281  ? 622 GLU   A N    1 
ATOM   3829 C CA   . GLU   A 1 260 ? 26.22839  -3.27790  45.25034  1.000 44.12199  ? 622 GLU   A CA   1 
ATOM   3830 C C    . GLU   A 1 260 ? 27.11606  -2.05603  45.39857  1.000 41.63148  ? 622 GLU   A C    1 
ATOM   3831 O O    . GLU   A 1 260 ? 27.08928  -1.39779  46.44185  1.000 46.65543  ? 622 GLU   A O    1 
ATOM   3832 C CB   . GLU   A 1 260 ? 26.98791  -4.52919  45.68897  1.000 42.77372  ? 622 GLU   A CB   1 
ATOM   3833 C CG   . GLU   A 1 260 ? 26.21918  -5.40849  46.67919  1.000 54.49111  ? 622 GLU   A CG   1 
ATOM   3834 C CD   . GLU   A 1 260 ? 27.13051  -6.31786  47.51494  1.000 81.81019  ? 622 GLU   A CD   1 
ATOM   3835 O OE1  . GLU   A 1 260 ? 28.35591  -6.38221  47.25344  1.000 79.11675  ? 622 GLU   A OE1  1 
ATOM   3836 O OE2  . GLU   A 1 260 ? 26.61442  -6.97491  48.44369  1.000 81.13797  ? 622 GLU   A OE2  1 
ATOM   3837 H H    . GLU   A 1 260 ? 25.93896  -4.16104  43.49809  1.000 49.50343  ? 622 GLU   A H    1 
ATOM   3838 H HA   . GLU   A 1 260 ? 25.46037  -3.18240  45.83508  1.000 52.95845  ? 622 GLU   A HA   1 
ATOM   3839 H HB2  . GLU   A 1 260 ? 27.18078  -5.06671  44.90489  1.000 51.34052  ? 622 GLU   A HB2  1 
ATOM   3840 H HB3  . GLU   A 1 260 ? 27.81509  -4.25704  46.11630  1.000 51.34052  ? 622 GLU   A HB3  1 
ATOM   3841 H HG2  . GLU   A 1 260 ? 25.72683  -4.83781  47.28977  1.000 65.40139  ? 622 GLU   A HG2  1 
ATOM   3842 H HG3  . GLU   A 1 260 ? 25.60500  -5.97446  46.18586  1.000 65.40139  ? 622 GLU   A HG3  1 
ATOM   3843 N N    . SER   A 1 261 ? 27.89212  -1.72851  44.36051  1.000 46.60513  ? 623 SER   A N    1 
ATOM   3844 C CA   . SER   A 1 261 ? 28.74420  -0.53890  44.39204  1.000 50.46400  ? 623 SER   A CA   1 
ATOM   3845 C C    . SER   A 1 261 ? 27.92746  0.74526   44.30663  1.000 48.59882  ? 623 SER   A C    1 
ATOM   3846 O O    . SER   A 1 261 ? 28.14195  1.68005   45.08633  1.000 54.56321  ? 623 SER   A O    1 
ATOM   3847 C CB   . SER   A 1 261 ? 29.75087  -0.58510  43.24173  1.000 53.58347  ? 623 SER   A CB   1 
ATOM   3848 O OG   . SER   A 1 261 ? 29.30965  0.24106   42.16851  1.000 62.37691  ? 623 SER   A OG   1 
ATOM   3849 H H    . SER   A 1 261 ? 27.94311  -2.17728  43.62866  1.000 55.93821  ? 623 SER   A H    1 
ATOM   3850 H HA   . SER   A 1 261 ? 29.22551  -0.53809  45.23421  1.000 60.56885  ? 623 SER   A HA   1 
ATOM   3851 H HB2  . SER   A 1 261 ? 30.61016  -0.26461  43.55766  1.000 64.31222  ? 623 SER   A HB2  1 
ATOM   3852 H HB3  . SER   A 1 261 ? 29.83291  -1.49895  42.92703  1.000 64.31222  ? 623 SER   A HB3  1 
ATOM   3853 H HG   . SER   A 1 261 ? 29.88362  0.24625   41.55522  1.000 74.86435  ? 623 SER   A HG   1 
ATOM   3854 N N    . GLY   A 1 262 ? 27.05893  0.85224   43.29713  1.000 52.47005  ? 624 GLY   A N    1 
ATOM   3855 C CA   . GLY   A 1 262 ? 26.03127  1.87587   43.25638  1.000 40.55341  ? 624 GLY   A CA   1 
ATOM   3856 C C    . GLY   A 1 262 ? 25.98973  2.76618   42.01857  1.000 51.99019  ? 624 GLY   A C    1 
ATOM   3857 O O    . GLY   A 1 262 ? 25.01173  3.48402   41.80274  1.000 59.17355  ? 624 GLY   A O    1 
ATOM   3858 H H    . GLY   A 1 262 ? 27.04952  0.33043   42.61359  1.000 62.97611  ? 624 GLY   A H    1 
ATOM   3859 H HA2  . GLY   A 1 262 ? 25.16725  1.44027   43.32439  1.000 48.67614  ? 624 GLY   A HA2  1 
ATOM   3860 H HA3  . GLY   A 1 262 ? 26.15288  2.45758   44.02302  1.000 48.67614  ? 624 GLY   A HA3  1 
ATOM   3861 N N    . GLY   A 1 263 ? 27.00456  2.72401   41.17153  1.000 44.23320  ? 625 GLY   A N    1 
ATOM   3862 C CA   . GLY   A 1 263 ? 27.11981  3.73609   40.13226  1.000 41.05087  ? 625 GLY   A CA   1 
ATOM   3863 C C    . GLY   A 1 263 ? 26.32186  3.52278   38.85829  1.000 43.22404  ? 625 GLY   A C    1 
ATOM   3864 O O    . GLY   A 1 263 ? 26.73554  3.99187   37.79094  1.000 32.33498  ? 625 GLY   A O    1 
ATOM   3865 H H    . GLY   A 1 263 ? 27.62830  2.13196   41.17597  1.000 53.09189  ? 625 GLY   A H    1 
ATOM   3866 H HA2  . GLY   A 1 263 ? 26.83671  4.58521   40.50609  1.000 49.27310  ? 625 GLY   A HA2  1 
ATOM   3867 H HA3  . GLY   A 1 263 ? 28.05313  3.79943   39.87576  1.000 49.27310  ? 625 GLY   A HA3  1 
ATOM   3868 N N    . LYS   A 1 264 ? 25.18395  2.83007   38.94547  1.000 39.35795  ? 626 LYS   A N    1 
ATOM   3869 C CA   . LYS   A 1 264 ? 24.34175  2.55241   37.77982  1.000 36.96074  ? 626 LYS   A CA   1 
ATOM   3870 C C    . LYS   A 1 264 ? 22.91292  2.40641   38.26813  1.000 30.90894  ? 626 LYS   A C    1 
ATOM   3871 O O    . LYS   A 1 264 ? 22.62601  1.51003   39.06724  1.000 30.91484  ? 626 LYS   A O    1 
ATOM   3872 C CB   . LYS   A 1 264 ? 24.77678  1.27047   37.06061  1.000 35.97125  ? 626 LYS   A CB   1 
ATOM   3873 C CG   . LYS   A 1 264 ? 25.84114  1.41509   35.97261  1.000 34.87411  ? 626 LYS   A CG   1 
ATOM   3874 C CD   . LYS   A 1 264 ? 26.12030  0.00412   35.39576  1.000 33.05886  ? 626 LYS   A CD   1 
ATOM   3875 C CE   . LYS   A 1 264 ? 26.87002  0.04233   34.10659  1.000 43.08820  ? 626 LYS   A CE   1 
ATOM   3876 N NZ   . LYS   A 1 264 ? 26.73478  -1.25564  33.36333  1.000 35.33591  ? 626 LYS   A NZ   1 
ATOM   3877 H H    . LYS   A 1 264 ? 24.87364  2.50557   39.67896  1.000 47.24160  ? 626 LYS   A H    1 
ATOM   3878 H HA   . LYS   A 1 264 ? 24.40406  3.29122   37.15438  1.000 44.36494  ? 626 LYS   A HA   1 
ATOM   3879 H HB2  . LYS   A 1 264 ? 25.13304  0.66031   37.72520  1.000 43.17756  ? 626 LYS   A HB2  1 
ATOM   3880 H HB3  . LYS   A 1 264 ? 23.99356  0.88245   36.64000  1.000 43.17756  ? 626 LYS   A HB3  1 
ATOM   3881 H HG2  . LYS   A 1 264 ? 25.51972  1.99358   35.26344  1.000 41.86098  ? 626 LYS   A HG2  1 
ATOM   3882 H HG3  . LYS   A 1 264 ? 26.65932  1.77513   36.34925  1.000 41.86098  ? 626 LYS   A HG3  1 
ATOM   3883 H HD2  . LYS   A 1 264 ? 26.64907  -0.49941  36.03432  1.000 39.68269  ? 626 LYS   A HD2  1 
ATOM   3884 H HD3  . LYS   A 1 264 ? 25.27543  -0.44524  35.23708  1.000 39.68269  ? 626 LYS   A HD3  1 
ATOM   3885 H HE2  . LYS   A 1 264 ? 26.51691  0.75320   33.54902  1.000 51.71790  ? 626 LYS   A HE2  1 
ATOM   3886 H HE3  . LYS   A 1 264 ? 27.81085  0.19692   34.28503  1.000 51.71790  ? 626 LYS   A HE3  1 
ATOM   3887 H HZ1  . LYS   A 1 264 ? 27.15838  -1.20471  32.58226  1.000 42.41515  ? 626 LYS   A HZ1  1 
ATOM   3888 H HZ2  . LYS   A 1 264 ? 27.08831  -1.91819  33.84098  1.000 42.41515  ? 626 LYS   A HZ2  1 
ATOM   3889 H HZ3  . LYS   A 1 264 ? 25.87543  -1.43326  33.21481  1.000 42.41515  ? 626 LYS   A HZ3  1 
ATOM   3890 N N    . ASP   A 1 265 ? 22.00834  3.27541   37.82151  1.000 32.37100  ? 627 ASP   A N    1 
ATOM   3891 C CA   . ASP   A 1 265 ? 20.68969  3.29944   38.44476  1.000 31.48055  ? 627 ASP   A CA   1 
ATOM   3892 C C    . ASP   A 1 265 ? 19.75808  4.15009   37.59429  1.000 28.39653  ? 627 ASP   A C    1 
ATOM   3893 O O    . ASP   A 1 265 ? 20.19733  4.91536   36.73027  1.000 26.76950  ? 627 ASP   A O    1 
ATOM   3894 C CB   . ASP   A 1 265 ? 20.79507  3.84384   39.87765  1.000 30.15458  ? 627 ASP   A CB   1 
ATOM   3895 C CG   . ASP   A 1 265 ? 19.58429  3.55810   40.74263  1.000 34.51940  ? 627 ASP   A CG   1 
ATOM   3896 O OD1  . ASP   A 1 265 ? 18.74603  2.68945   40.40703  1.000 33.29841  ? 627 ASP   A OD1  1 
ATOM   3897 O OD2  . ASP   A 1 265 ? 19.46306  4.25767   41.78489  1.000 34.45094  ? 627 ASP   A OD2  1 
ATOM   3898 H H    . ASP   A 1 265 ? 22.13067  3.83898   37.18353  1.000 38.85726  ? 627 ASP   A H    1 
ATOM   3899 H HA   . ASP   A 1 265 ? 20.31043  2.40709   38.47264  1.000 37.78872  ? 627 ASP   A HA   1 
ATOM   3900 H HB2  . ASP   A 1 265 ? 21.56490  3.43943   40.30743  1.000 36.19755  ? 627 ASP   A HB2  1 
ATOM   3901 H HB3  . ASP   A 1 265 ? 20.90580  4.80661   39.83647  1.000 36.19755  ? 627 ASP   A HB3  1 
ATOM   3902 N N    . SER   A 1 266 ? 18.46839  3.98944   37.83257  1.000 28.61860  ? 628 SER   A N    1 
ATOM   3903 C CA   . SER   A 1 266 ? 17.44493  4.89412   37.32320  1.000 30.11017  ? 628 SER   A CA   1 
ATOM   3904 C C    . SER   A 1 266 ? 17.11396  5.86795   38.44908  1.000 29.58588  ? 628 SER   A C    1 
ATOM   3905 O O    . SER   A 1 266 ? 17.31871  5.56026   39.62351  1.000 31.43777  ? 628 SER   A O    1 
ATOM   3906 C CB   . SER   A 1 266 ? 16.20061  4.12271   36.84871  1.000 25.68040  ? 628 SER   A CB   1 
ATOM   3907 O OG   . SER   A 1 266 ? 15.59923  3.38425   37.90114  1.000 32.44513  ? 628 SER   A OG   1 
ATOM   3908 H H    . SER   A 1 266 ? 18.14746  3.34397   38.30159  1.000 34.35437  ? 628 SER   A H    1 
ATOM   3909 H HA   . SER   A 1 266 ? 17.75102  5.38928   36.54730  1.000 36.14426  ? 628 SER   A HA   1 
ATOM   3910 H HB2  . SER   A 1 266 ? 15.55316  4.75792   36.50491  1.000 30.82853  ? 628 SER   A HB2  1 
ATOM   3911 H HB3  . SER   A 1 266 ? 16.46515  3.50643   36.14791  1.000 30.82853  ? 628 SER   A HB3  1 
ATOM   3912 H HG   . SER   A 1 266 ? 16.13681  2.80765   38.19121  1.000 38.94621  ? 628 SER   A HG   1 
ATOM   3913 N N    . CYS   A 1 267 ? 16.64752  7.06188   38.09115  1.000 33.91990  ? 629 CYS   A N    1 
ATOM   3914 C CA   . CYS   A 1 267 ? 16.44797  8.12659   39.07119  1.000 32.85835  ? 629 CYS   A CA   1 
ATOM   3915 C C    . CYS   A 1 267 ? 15.14989  8.86614   38.78975  1.000 35.76875  ? 629 CYS   A C    1 
ATOM   3916 O O    . CYS   A 1 267 ? 14.43217  8.55213   37.84040  1.000 34.33441  ? 629 CYS   A O    1 
ATOM   3917 C CB   . CYS   A 1 267 ? 17.59627  9.13402   39.04292  1.000 28.66497  ? 629 CYS   A CB   1 
ATOM   3918 S SG   . CYS   A 1 267 ? 19.19261  8.45605   38.76943  1.000 40.72191  ? 629 CYS   A SG   1 
ATOM   3919 H H    . CYS   A 1 267 ? 16.43918  7.27955   37.28566  1.000 40.71593  ? 629 CYS   A H    1 
ATOM   3920 H HA   . CYS   A 1 267 ? 16.39116  7.70026   39.94062  1.000 39.44207  ? 629 CYS   A HA   1 
ATOM   3921 H HB2  . CYS   A 1 267 ? 17.42666  9.76935   38.32984  1.000 34.41002  ? 629 CYS   A HB2  1 
ATOM   3922 H HB3  . CYS   A 1 267 ? 17.62019  9.59276   39.89725  1.000 34.41002  ? 629 CYS   A HB3  1 
ATOM   3923 N N    . ARG   A 1 268 ? 14.87338  9.88933   39.60664  1.000 34.42962  ? 630 ARG   A N    1 
ATOM   3924 C CA   . ARG   A 1 268 ? 13.72601  10.75891  39.37508  1.000 30.54746  ? 630 ARG   A CA   1 
ATOM   3925 C C    . ARG   A 1 268 ? 13.76435  11.27400  37.94428  1.000 25.97821  ? 630 ARG   A C    1 
ATOM   3926 O O    . ARG   A 1 268 ? 14.82232  11.65370  37.45134  1.000 28.90886  ? 630 ARG   A O    1 
ATOM   3927 C CB   . ARG   A 1 268 ? 13.72812  11.94068  40.38032  1.000 38.23640  ? 630 ARG   A CB   1 
ATOM   3928 C CG   . ARG   A 1 268 ? 12.44193  12.81040  40.30586  1.000 59.33802  ? 630 ARG   A CG   1 
ATOM   3929 C CD   . ARG   A 1 268 ? 12.62548  14.33553  40.49956  1.000 61.93339  ? 630 ARG   A CD   1 
ATOM   3930 N NE   . ARG   A 1 268 ? 11.86803  15.04867  39.46804  1.000 58.40099  ? 630 ARG   A NE   1 
ATOM   3931 C CZ   . ARG   A 1 268 ? 12.05624  16.30986  39.09784  1.000 67.21305  ? 630 ARG   A CZ   1 
ATOM   3932 N NH1  . ARG   A 1 268 ? 12.77401  17.14266  39.82152  1.000 68.25947  ? 630 ARG   A NH1  1 
ATOM   3933 N NH2  . ARG   A 1 268 ? 11.48864  16.74919  37.97242  1.000 58.86977  ? 630 ARG   A NH2  1 
ATOM   3934 H H    . ARG   A 1 268 ? 15.33698  10.09757  40.30041  1.000 41.32759  ? 630 ARG   A H    1 
ATOM   3935 H HA   . ARG   A 1 268 ? 12.90174  10.26616  39.51177  1.000 36.66901  ? 630 ARG   A HA   1 
ATOM   3936 H HB2  . ARG   A 1 268 ? 13.79739  11.58674  41.28078  1.000 45.89573  ? 630 ARG   A HB2  1 
ATOM   3937 H HB3  . ARG   A 1 268 ? 14.48730  12.51358  40.18973  1.000 45.89573  ? 630 ARG   A HB3  1 
ATOM   3938 H HG2  . ARG   A 1 268 ? 12.04107  12.68218  39.43192  1.000 71.21768  ? 630 ARG   A HG2  1 
ATOM   3939 H HG3  . ARG   A 1 268 ? 11.83288  12.50837  40.99776  1.000 71.21768  ? 630 ARG   A HG3  1 
ATOM   3940 H HD2  . ARG   A 1 268 ? 12.29359  14.59920  41.37204  1.000 74.33212  ? 630 ARG   A HD2  1 
ATOM   3941 H HD3  . ARG   A 1 268 ? 13.56374  14.56757  40.41750  1.000 74.33212  ? 630 ARG   A HD3  1 
ATOM   3942 H HE   . ARG   A 1 268 ? 11.24590  14.61136  39.06640  1.000 70.09324  ? 630 ARG   A HE   1 
ATOM   3943 H HH11 . ARG   A 1 268 ? 13.13498  16.87422  40.55448  1.000 81.92342  ? 630 ARG   A HH11 1 
ATOM   3944 H HH12 . ARG   A 1 268 ? 12.88202  17.95522  39.56138  1.000 81.92342  ? 630 ARG   A HH12 1 
ATOM   3945 H HH21 . ARG   A 1 268 ? 11.00811  16.21739  37.49716  1.000 70.65578  ? 630 ARG   A HH21 1 
ATOM   3946 H HH22 . ARG   A 1 268 ? 11.60348  17.56405  37.72259  1.000 70.65578  ? 630 ARG   A HH22 1 
ATOM   3947 N N    . GLY   A 1 269 ? 12.60432  11.25089  37.27009  1.000 28.52439  ? 631 GLY   A N    1 
ATOM   3948 C CA   . GLY   A 1 269 ? 12.48256  11.58171  35.86144  1.000 27.58540  ? 631 GLY   A CA   1 
ATOM   3949 C C    . GLY   A 1 269 ? 12.54403  10.39838  34.92352  1.000 24.70541  ? 631 GLY   A C    1 
ATOM   3950 O O    . GLY   A 1 269 ? 12.12307  10.51627  33.77828  1.000 23.32858  ? 631 GLY   A O    1 
ATOM   3951 H H    . GLY   A 1 269 ? 11.85236  11.03769  37.62884  1.000 34.24132  ? 631 GLY   A H    1 
ATOM   3952 H HA2  . GLY   A 1 269 ? 11.63307  12.02792  35.71945  1.000 33.11454  ? 631 GLY   A HA2  1 
ATOM   3953 H HA3  . GLY   A 1 269 ? 13.20133  12.18719  35.62129  1.000 33.11454  ? 631 GLY   A HA3  1 
ATOM   3954 N N    . ASP   A 1 270 ? 13.05868  9.26026   35.38197  1.000 26.29800  ? 632 ASP   A N    1 
ATOM   3955 C CA   . ASP   A 1 270 ? 12.99054  8.01400   34.62453  1.000 27.81550  ? 632 ASP   A CA   1 
ATOM   3956 C C    . ASP   A 1 270 ? 11.71028  7.22311   34.87671  1.000 26.70470  ? 632 ASP   A C    1 
ATOM   3957 O O    . ASP   A 1 270 ? 11.47591  6.22845   34.17457  1.000 21.51136  ? 632 ASP   A O    1 
ATOM   3958 C CB   . ASP   A 1 270 ? 14.18054  7.13193   34.97387  1.000 25.92708  ? 632 ASP   A CB   1 
ATOM   3959 C CG   . ASP   A 1 270 ? 15.49988  7.77721   34.60893  1.000 25.81028  ? 632 ASP   A CG   1 
ATOM   3960 O OD1  . ASP   A 1 270 ? 15.60138  8.37817   33.51413  1.000 26.69858  ? 632 ASP   A OD1  1 
ATOM   3961 O OD2  . ASP   A 1 270 ? 16.42876  7.71427   35.41274  1.000 27.15211  ? 632 ASP   A OD2  1 
ATOM   3962 H H    . ASP   A 1 270 ? 13.45802  9.18310   36.13971  1.000 31.56965  ? 632 ASP   A H    1 
ATOM   3963 H HA   . ASP   A 1 270 ? 13.02854  8.22940   33.67951  1.000 33.39066  ? 632 ASP   A HA   1 
ATOM   3964 H HB2  . ASP   A 1 270 ? 14.18122  6.96258   35.92897  1.000 31.12455  ? 632 ASP   A HB2  1 
ATOM   3965 H HB3  . ASP   A 1 270 ? 14.10927  6.29507   34.48860  1.000 31.12455  ? 632 ASP   A HB3  1 
ATOM   3966 N N    . SER   A 1 271 ? 10.93130  7.63020   35.88453  1.000 25.22630  ? 633 SER   A N    1 
ATOM   3967 C CA   . SER   A 1 271 ? 9.66771   7.00139   36.28137  1.000 22.24602  ? 633 SER   A CA   1 
ATOM   3968 C C    . SER   A 1 271 ? 8.86103   6.54546   35.08076  1.000 27.61817  ? 633 SER   A C    1 
ATOM   3969 O O    . SER   A 1 271 ? 8.68205   7.30385   34.12792  1.000 28.54923  ? 633 SER   A O    1 
ATOM   3970 C CB   . SER   A 1 271 ? 8.81254   7.99948   37.07165  1.000 25.22988  ? 633 SER   A CB   1 
ATOM   3971 O OG   . SER   A 1 271 ? 9.33740   8.29523   38.33902  1.000 31.76380  ? 633 SER   A OG   1 
ATOM   3972 H H    . SER   A 1 271 ? 11.12314  8.30559   36.38117  1.000 30.28361  ? 633 SER   A H    1 
ATOM   3973 H HA   . SER   A 1 271 ? 9.88019   6.23282   36.83369  1.000 26.70728  ? 633 SER   A HA   1 
ATOM   3974 H HB2  . SER   A 1 271 ? 8.75596   8.82386   36.56361  1.000 30.28791  ? 633 SER   A HB2  1 
ATOM   3975 H HB3  . SER   A 1 271 ? 7.92747   7.61988   37.18767  1.000 30.28791  ? 633 SER   A HB3  1 
ATOM   3976 H HG   . SER   A 1 271 ? 10.09771  8.64370   38.26093  1.000 38.12861  ? 633 SER   A HG   1 
ATOM   3977 N N    . GLY   A 1 272 ? 8.36517   5.30391   35.13879  1.000 25.60452  ? 634 GLY   A N    1 
ATOM   3978 C CA   . GLY   A 1 272 ? 7.56542   4.76602   34.07361  1.000 23.74471  ? 634 GLY   A CA   1 
ATOM   3979 C C    . GLY   A 1 272 ? 8.33348   4.20623   32.89859  1.000 27.32480  ? 634 GLY   A C    1 
ATOM   3980 O O    . GLY   A 1 272 ? 7.72432   3.55900   32.03804  1.000 27.34292  ? 634 GLY   A O    1 
ATOM   3981 H H    . GLY   A 1 272 ? 8.48771   4.76248   35.79562  1.000 30.73747  ? 634 GLY   A H    1 
ATOM   3982 H HA2  . GLY   A 1 272 ? 7.01670   4.05091   34.43197  1.000 28.50571  ? 634 GLY   A HA2  1 
ATOM   3983 H HA3  . GLY   A 1 272 ? 6.98786   5.46911   33.73747  1.000 28.50571  ? 634 GLY   A HA3  1 
ATOM   3984 N N    . GLY   A 1 273 ? 9.63710   4.43675   32.80443  1.000 26.60358  ? 635 GLY   A N    1 
ATOM   3985 C CA   . GLY   A 1 273 ? 10.39976  3.86018   31.71107  1.000 25.90890  ? 635 GLY   A CA   1 
ATOM   3986 C C    . GLY   A 1 273 ? 10.40563  2.34206   31.76643  1.000 27.94284  ? 635 GLY   A C    1 
ATOM   3987 O O    . GLY   A 1 273 ? 10.17361  1.74442   32.80559  1.000 27.02786  ? 635 GLY   A O    1 
ATOM   3988 H H    . GLY   A 1 273 ? 10.09538  4.91581   33.35222  1.000 31.93635  ? 635 GLY   A H    1 
ATOM   3989 H HA2  . GLY   A 1 273 ? 10.01239  4.13621   30.86570  1.000 31.10274  ? 635 GLY   A HA2  1 
ATOM   3990 H HA3  . GLY   A 1 273 ? 11.31661  4.17371   31.75567  1.000 31.10274  ? 635 GLY   A HA3  1 
ATOM   3991 N N    . ALA   A 1 274 ? 10.65829  1.71328   30.61768  1.000 22.12411  ? 636 ALA   A N    1 
ATOM   3992 C CA   . ALA   A 1 274 ? 10.70157  0.26036   30.53370  1.000 26.38927  ? 636 ALA   A CA   1 
ATOM   3993 C C    . ALA   A 1 274 ? 12.09121  -0.22082  30.88855  1.000 27.28525  ? 636 ALA   A C    1 
ATOM   3994 O O    . ALA   A 1 274 ? 13.07355  0.22890   30.28338  1.000 24.40272  ? 636 ALA   A O    1 
ATOM   3995 C CB   . ALA   A 1 274 ? 10.33884  -0.23532  29.13881  1.000 25.27949  ? 636 ALA   A CB   1 
ATOM   3996 H H    . ALA   A 1 274 ? 10.80836  2.11200   29.87062  1.000 26.56099  ? 636 ALA   A H    1 
ATOM   3997 H HA   . ALA   A 1 274 ? 10.05735  -0.10563  31.15974  1.000 31.67918  ? 636 ALA   A HA   1 
ATOM   3998 H HB1  . ALA   A 1 274 ? 10.61113  -1.16230  29.05235  1.000 30.34744  ? 636 ALA   A HB1  1 
ATOM   3999 H HB2  . ALA   A 1 274 ? 9.37960   -0.15953  29.01627  1.000 30.34744  ? 636 ALA   A HB2  1 
ATOM   4000 H HB3  . ALA   A 1 274 ? 10.80030  0.30774   28.48076  1.000 30.34744  ? 636 ALA   A HB3  1 
ATOM   4001 N N    . LEU   A 1 275 ? 12.17036  -1.15325  31.83851  1.000 24.22308  ? 637 LEU   A N    1 
ATOM   4002 C CA   . LEU   A 1 275 ? 13.39552  -1.92987  32.04247  1.000 25.01199  ? 637 LEU   A CA   1 
ATOM   4003 C C    . LEU   A 1 275 ? 13.28596  -3.12062  31.11130  1.000 25.91962  ? 637 LEU   A C    1 
ATOM   4004 O O    . LEU   A 1 275 ? 12.39941  -3.96907  31.28569  1.000 25.59426  ? 637 LEU   A O    1 
ATOM   4005 C CB   . LEU   A 1 275 ? 13.56377  -2.35574  33.49190  1.000 25.89167  ? 637 LEU   A CB   1 
ATOM   4006 C CG   . LEU   A 1 275 ? 14.84560  -3.14057  33.81794  1.000 25.77494  ? 637 LEU   A CG   1 
ATOM   4007 C CD1  . LEU   A 1 275 ? 16.01461  -2.19787  33.90223  1.000 29.31588  ? 637 LEU   A CD1  1 
ATOM   4008 C CD2  . LEU   A 1 275 ? 14.70265  -3.87732  35.13320  1.000 27.57776  ? 637 LEU   A CD2  1 
ATOM   4009 H H    . LEU   A 1 275 ? 11.53005  -1.35423  32.37629  1.000 29.07975  ? 637 LEU   A H    1 
ATOM   4010 H HA   . LEU   A 1 275 ? 14.17945  -1.40097  31.82653  1.000 30.02644  ? 637 LEU   A HA   1 
ATOM   4011 H HB2  . LEU   A 1 275 ? 13.56719  -1.55775  34.04336  1.000 31.08206  ? 637 LEU   A HB2  1 
ATOM   4012 H HB3  . LEU   A 1 275 ? 12.81226  -2.92070  33.73053  1.000 31.08206  ? 637 LEU   A HB3  1 
ATOM   4013 H HG   . LEU   A 1 275 ? 15.00315  -3.78973  33.11462  1.000 30.94199  ? 637 LEU   A HG   1 
ATOM   4014 H HD11 . LEU   A 1 275 ? 16.82824  -2.71325  34.01751  1.000 35.19111  ? 637 LEU   A HD11 1 
ATOM   4015 H HD12 . LEU   A 1 275 ? 16.06354  -1.68139  33.08262  1.000 35.19111  ? 637 LEU   A HD12 1 
ATOM   4016 H HD13 . LEU   A 1 275 ? 15.88838  -1.60518  34.65965  1.000 35.19111  ? 637 LEU   A HD13 1 
ATOM   4017 H HD21 . LEU   A 1 275 ? 15.50761  -4.39382  35.29496  1.000 33.10537  ? 637 LEU   A HD21 1 
ATOM   4018 H HD22 . LEU   A 1 275 ? 14.57581  -3.23083  35.84514  1.000 33.10537  ? 637 LEU   A HD22 1 
ATOM   4019 H HD23 . LEU   A 1 275 ? 13.93510  -4.46824  35.08236  1.000 33.10537  ? 637 LEU   A HD23 1 
ATOM   4020 N N    . VAL   A 1 276 ? 14.13688  -3.14618  30.09068  1.000 24.55523  ? 638 VAL   A N    1 
ATOM   4021 C CA   . VAL   A 1 276 ? 13.98951  -4.11068  29.02125  1.000 24.18822  ? 638 VAL   A CA   1 
ATOM   4022 C C    . VAL   A 1 276 ? 15.06783  -5.17166  29.10614  1.000 27.94762  ? 638 VAL   A C    1 
ATOM   4023 O O    . VAL   A 1 276 ? 16.18740  -4.95811  29.61021  1.000 27.01436  ? 638 VAL   A O    1 
ATOM   4024 C CB   . VAL   A 1 276 ? 14.00542  -3.47180  27.61294  1.000 25.39259  ? 638 VAL   A CB   1 
ATOM   4025 C CG1  . VAL   A 1 276 ? 12.75098  -2.69717  27.40048  1.000 23.21296  ? 638 VAL   A CG1  1 
ATOM   4026 C CG2  . VAL   A 1 276 ? 15.25274  -2.62725  27.37064  1.000 24.58874  ? 638 VAL   A CG2  1 
ATOM   4027 H H    . VAL   A 1 276 ? 14.80551  -2.61289  30.00042  1.000 29.47833  ? 638 VAL   A H    1 
ATOM   4028 H HA   . VAL   A 1 276 ? 13.13060  -4.53994  29.15876  1.000 29.03792  ? 638 VAL   A HA   1 
ATOM   4029 H HB   . VAL   A 1 276 ? 14.04305  -4.17954  26.95069  1.000 30.48317  ? 638 VAL   A HB   1 
ATOM   4030 H HG11 . VAL   A 1 276 ? 12.76860  -2.30462  26.51363  1.000 27.86760  ? 638 VAL   A HG11 1 
ATOM   4031 H HG12 . VAL   A 1 276 ? 11.99233  -3.29607  27.48211  1.000 27.86760  ? 638 VAL   A HG12 1 
ATOM   4032 H HG13 . VAL   A 1 276 ? 12.69417  -1.99812  28.07056  1.000 27.86760  ? 638 VAL   A HG13 1 
ATOM   4033 H HG21 . VAL   A 1 276 ? 15.22070  -2.26774  26.47029  1.000 29.51854  ? 638 VAL   A HG21 1 
ATOM   4034 H HG22 . VAL   A 1 276 ? 15.27385  -1.90293  28.01548  1.000 29.51854  ? 638 VAL   A HG22 1 
ATOM   4035 H HG23 . VAL   A 1 276 ? 16.03819  -3.18665  27.47570  1.000 29.51854  ? 638 VAL   A HG23 1 
ATOM   4036 N N    . PHE   A 1 277 ? 14.73892  -6.31268  28.52562  1.000 21.38799  ? 639 PHE   A N    1 
ATOM   4037 C CA   . PHE   A 1 277 ? 15.63093  -7.46062  28.47762  1.000 23.81633  ? 639 PHE   A CA   1 
ATOM   4038 C C    . PHE   A 1 277 ? 15.54873  -8.07225  27.09646  1.000 25.60110  ? 639 PHE   A C    1 
ATOM   4039 O O    . PHE   A 1 277 ? 14.51016  -7.97633  26.44532  1.000 23.13896  ? 639 PHE   A O    1 
ATOM   4040 C CB   . PHE   A 1 277 ? 15.26251  -8.54687  29.49027  1.000 23.47082  ? 639 PHE   A CB   1 
ATOM   4041 C CG   . PHE   A 1 277 ? 15.28592  -8.09276  30.89680  1.000 25.10613  ? 639 PHE   A CG   1 
ATOM   4042 C CD1  . PHE   A 1 277 ? 14.21680  -7.38949  31.42172  1.000 24.64886  ? 639 PHE   A CD1  1 
ATOM   4043 C CD2  . PHE   A 1 277 ? 16.37930  -8.38373  31.72011  1.000 29.42602  ? 639 PHE   A CD2  1 
ATOM   4044 C CE1  . PHE   A 1 277 ? 14.23783  -6.94532  32.74653  1.000 28.83493  ? 639 PHE   A CE1  1 
ATOM   4045 C CE2  . PHE   A 1 277 ? 16.41669  -7.92277  33.04490  1.000 26.95075  ? 639 PHE   A CE2  1 
ATOM   4046 C CZ   . PHE   A 1 277 ? 15.35076  -7.20306  33.55147  1.000 28.28200  ? 639 PHE   A CZ   1 
ATOM   4047 H H    . PHE   A 1 277 ? 13.98271  -6.45255  28.14067  1.000 25.67764  ? 639 PHE   A H    1 
ATOM   4048 H HA   . PHE   A 1 277 ? 16.53218  -7.15632  28.66749  1.000 28.59165  ? 639 PHE   A HA   1 
ATOM   4049 H HB2  . PHE   A 1 277 ? 14.36528  -8.86058  29.29674  1.000 28.17703  ? 639 PHE   A HB2  1 
ATOM   4050 H HB3  . PHE   A 1 277 ? 15.89485  -9.27757  29.40592  1.000 28.17703  ? 639 PHE   A HB3  1 
ATOM   4051 H HD1  . PHE   A 1 277 ? 13.47671  -7.21047  30.88776  1.000 29.59068  ? 639 PHE   A HD1  1 
ATOM   4052 H HD2  . PHE   A 1 277 ? 17.08691  -8.88668  31.38659  1.000 35.32328  ? 639 PHE   A HD2  1 
ATOM   4053 H HE1  . PHE   A 1 277 ? 13.51161  -6.47848  33.09233  1.000 34.61397  ? 639 PHE   A HE1  1 
ATOM   4054 H HE2  . PHE   A 1 277 ? 17.15601  -8.10084  33.58025  1.000 32.35295  ? 639 PHE   A HE2  1 
ATOM   4055 H HZ   . PHE   A 1 277 ? 15.37424  -6.89067  34.42711  1.000 33.95045  ? 639 PHE   A HZ   1 
ATOM   4056 N N    . LEU   A 1 278 ? 16.62523  -8.74196  26.67862  1.000 26.93798  ? 640 LEU   A N    1 
ATOM   4057 C CA   . LEU   A 1 278 ? 16.67690  -9.39677  25.37585  1.000 27.74084  ? 640 LEU   A CA   1 
ATOM   4058 C C    . LEU   A 1 278 ? 16.20154  -10.84314 25.49585  1.000 27.05476  ? 640 LEU   A C    1 
ATOM   4059 O O    . LEU   A 1 278 ? 16.83048  -11.66326 26.16347  1.000 25.53094  ? 640 LEU   A O    1 
ATOM   4060 C CB   . LEU   A 1 278 ? 18.08908  -9.35756  24.78625  1.000 29.35695  ? 640 LEU   A CB   1 
ATOM   4061 C CG   . LEU   A 1 278 ? 18.25035  -9.95308  23.37550  1.000 32.56094  ? 640 LEU   A CG   1 
ATOM   4062 C CD1  . LEU   A 1 278 ? 17.42791  -9.21090  22.34623  1.000 33.04318  ? 640 LEU   A CD1  1 
ATOM   4063 C CD2  . LEU   A 1 278 ? 19.73047  -9.94206  22.95474  1.000 34.73487  ? 640 LEU   A CD2  1 
ATOM   4064 H H    . LEU   A 1 278 ? 17.34579  -8.83067  27.13963  1.000 32.33763  ? 640 LEU   A H    1 
ATOM   4065 H HA   . LEU   A 1 278 ? 16.07924  -8.92303  24.77646  1.000 33.30106  ? 640 LEU   A HA   1 
ATOM   4066 H HB2  . LEU   A 1 278 ? 18.37168  -8.43078  24.74042  1.000 35.24039  ? 640 LEU   A HB2  1 
ATOM   4067 H HB3  . LEU   A 1 278 ? 18.67675  -9.85480  25.37641  1.000 35.24039  ? 640 LEU   A HB3  1 
ATOM   4068 H HG   . LEU   A 1 278 ? 17.92901  -10.86784 23.40488  1.000 39.08519  ? 640 LEU   A HG   1 
ATOM   4069 H HD11 . LEU   A 1 278 ? 17.65563  -9.54033  21.46276  1.000 39.66388  ? 640 LEU   A HD11 1 
ATOM   4070 H HD12 . LEU   A 1 278 ? 16.48670  -9.36406  22.52391  1.000 39.66388  ? 640 LEU   A HD12 1 
ATOM   4071 H HD13 . LEU   A 1 278 ? 17.62611  -8.26333  22.40717  1.000 39.66388  ? 640 LEU   A HD13 1 
ATOM   4072 H HD21 . LEU   A 1 278 ? 19.81454  -10.36219 22.08450  1.000 41.69390  ? 640 LEU   A HD21 1 
ATOM   4073 H HD22 . LEU   A 1 278 ? 20.03919  -9.02359  22.90984  1.000 41.69390  ? 640 LEU   A HD22 1 
ATOM   4074 H HD23 . LEU   A 1 278 ? 20.24896  -10.43360 23.61083  1.000 41.69390  ? 640 LEU   A HD23 1 
ATOM   4075 N N    . ASP   A 1 279 ? 15.12024  -11.16902 24.81652  1.000 27.50496  ? 641 ASP   A N    1 
ATOM   4076 C CA   . ASP   A 1 279 ? 14.79000  -12.57664 24.57855  1.000 30.90229  ? 641 ASP   A CA   1 
ATOM   4077 C C    . ASP   A 1 279 ? 15.76673  -13.09463 23.53355  1.000 30.67974  ? 641 ASP   A C    1 
ATOM   4078 O O    . ASP   A 1 279 ? 15.57516  -12.88601 22.33635  1.000 32.53937  ? 641 ASP   A O    1 
ATOM   4079 C CB   . ASP   A 1 279 ? 13.34895  -12.71103 24.10619  1.000 31.61324  ? 641 ASP   A CB   1 
ATOM   4080 C CG   . ASP   A 1 279 ? 12.86394  -14.15255 24.08230  1.000 34.99391  ? 641 ASP   A CG   1 
ATOM   4081 O OD1  . ASP   A 1 279 ? 13.58513  -15.03870 23.56286  1.000 33.91246  ? 641 ASP   A OD1  1 
ATOM   4082 O OD2  . ASP   A 1 279 ? 11.74937  -14.38981 24.58840  1.000 37.99946  ? 641 ASP   A OD2  1 
ATOM   4083 H H    . ASP   A 1 279 ? 14.56225  -10.60598 24.48301  1.000 33.01801  ? 641 ASP   A H    1 
ATOM   4084 H HA   . ASP   A 1 279 ? 14.88101  -13.09227 25.39509  1.000 37.09480  ? 641 ASP   A HA   1 
ATOM   4085 H HB2  . ASP   A 1 279 ? 12.77277  -12.21159 24.70576  1.000 37.94795  ? 641 ASP   A HB2  1 
ATOM   4086 H HB3  . ASP   A 1 279 ? 13.27790  -12.35669 23.20603  1.000 37.94795  ? 641 ASP   A HB3  1 
ATOM   4087 N N    . SER   A 1 280 ? 16.81836  -13.78056 23.96715  1.000 29.21020  ? 642 SER   A N    1 
ATOM   4088 C CA   . SER   A 1 280 ? 17.89463  -14.10630 23.02886  1.000 34.51647  ? 642 SER   A CA   1 
ATOM   4089 C C    . SER   A 1 280 ? 17.46524  -15.12322 21.98232  1.000 34.40789  ? 642 SER   A C    1 
ATOM   4090 O O    . SER   A 1 280 ? 18.12643  -15.22628 20.95301  1.000 37.42486  ? 642 SER   A O    1 
ATOM   4091 C CB   . SER   A 1 280 ? 19.13663  -14.61106 23.77820  1.000 29.37317  ? 642 SER   A CB   1 
ATOM   4092 O OG   . SER   A 1 280 ? 18.82269  -15.77308 24.52049  1.000 37.76633  ? 642 SER   A OG   1 
ATOM   4093 H H    . SER   A 1 280 ? 16.93269  -14.06139 24.77193  1.000 35.06429  ? 642 SER   A H    1 
ATOM   4094 H HA   . SER   A 1 280 ? 18.14793  -13.29258 22.56561  1.000 41.43182  ? 642 SER   A HA   1 
ATOM   4095 H HB2  . SER   A 1 280 ? 19.83174  -14.82240 23.13550  1.000 35.25986  ? 642 SER   A HB2  1 
ATOM   4096 H HB3  . SER   A 1 280 ? 19.44479  -13.91977 24.38488  1.000 35.25986  ? 642 SER   A HB3  1 
ATOM   4097 H HG   . SER   A 1 280 ? 19.50248  -16.04216 24.93411  1.000 45.33165  ? 642 SER   A HG   1 
ATOM   4098 N N    . GLU   A 1 281 ? 16.35858  -15.83288 22.20638  1.000 33.05819  ? 643 GLU   A N    1 
ATOM   4099 C CA   . GLU   A 1 281 ? 15.81988  -16.81767 21.27203  1.000 34.11875  ? 643 GLU   A CA   1 
ATOM   4100 C C    . GLU   A 1 281 ? 14.89353  -16.21003 20.22585  1.000 33.98681  ? 643 GLU   A C    1 
ATOM   4101 O O    . GLU   A 1 281 ? 15.01182  -16.52391 19.04212  1.000 34.70131  ? 643 GLU   A O    1 
ATOM   4102 C CB   . GLU   A 1 281 ? 15.08006  -17.89827 22.05174  1.000 34.26758  ? 643 GLU   A CB   1 
ATOM   4103 C CG   . GLU   A 1 281 ? 16.00885  -18.82645 22.83040  1.000 38.55859  ? 643 GLU   A CG   1 
ATOM   4104 C CD   . GLU   A 1 281 ? 16.99686  -19.53583 21.92531  1.000 51.68525  ? 643 GLU   A CD   1 
ATOM   4105 O OE1  . GLU   A 1 281 ? 16.55818  -20.03527 20.86945  1.000 46.38036  ? 643 GLU   A OE1  1 
ATOM   4106 O OE2  . GLU   A 1 281 ? 18.20441  -19.55000 22.24799  1.000 56.75222  ? 643 GLU   A OE2  1 
ATOM   4107 H H    . GLU   A 1 281 ? 15.88435  -15.75859 22.91996  1.000 39.68189  ? 643 GLU   A H    1 
ATOM   4108 H HA   . GLU   A 1 281 ? 16.56292  -17.21873 20.79461  1.000 40.95455  ? 643 GLU   A HA   1 
ATOM   4109 H HB2  . GLU   A 1 281 ? 14.48301  -17.47300 22.68702  1.000 41.13315  ? 643 GLU   A HB2  1 
ATOM   4110 H HB3  . GLU   A 1 281 ? 14.57060  -18.44045 21.42933  1.000 41.13315  ? 643 GLU   A HB3  1 
ATOM   4111 H HG2  . GLU   A 1 281 ? 16.51058  -18.30586 23.47705  1.000 46.28236  ? 643 GLU   A HG2  1 
ATOM   4112 H HG3  . GLU   A 1 281 ? 15.47857  -19.49907 23.28569  1.000 46.28236  ? 643 GLU   A HG3  1 
ATOM   4113 N N    . THR   A 1 282 ? 13.93634  -15.37331 20.63328  1.000 33.45962  ? 644 THR   A N    1 
ATOM   4114 C CA   . THR   A 1 282 ? 13.16375  -14.64433 19.63286  1.000 35.72968  ? 644 THR   A CA   1 
ATOM   4115 C C    . THR   A 1 282 ? 13.95486  -13.48733 19.04482  1.000 29.24085  ? 644 THR   A C    1 
ATOM   4116 O O    . THR   A 1 282 ? 13.57772  -12.97138 17.99177  1.000 37.61368  ? 644 THR   A O    1 
ATOM   4117 C CB   . THR   A 1 282 ? 11.85301  -14.11231 20.21809  1.000 38.38631  ? 644 THR   A CB   1 
ATOM   4118 O OG1  . THR   A 1 282 ? 12.13293  -13.04202 21.12890  1.000 34.04460  ? 644 THR   A OG1  1 
ATOM   4119 C CG2  . THR   A 1 282 ? 11.08607  -15.22909 20.93112  1.000 36.88863  ? 644 THR   A CG2  1 
ATOM   4120 H H    . THR   A 1 282 ? 13.72484  -15.21784 21.45224  1.000 40.16359  ? 644 THR   A H    1 
ATOM   4121 H HA   . THR   A 1 282 ? 12.92603  -15.26168 18.92344  1.000 42.88767  ? 644 THR   A HA   1 
ATOM   4122 H HB   . THR   A 1 282 ? 11.28820  -13.77750 19.50410  1.000 46.07563  ? 644 THR   A HB   1 
ATOM   4123 H HG1  . THR   A 1 282 ? 11.42354  -12.78745 21.49979  1.000 40.86557  ? 644 THR   A HG1  1 
ATOM   4124 H HG21 . THR   A 1 282 ? 10.18872  -14.93020 21.14637  1.000 44.27841  ? 644 THR   A HG21 1 
ATOM   4125 H HG22 . THR   A 1 282 ? 11.02892  -16.01010 20.35871  1.000 44.27841  ? 644 THR   A HG22 1 
ATOM   4126 H HG23 . THR   A 1 282 ? 11.54199  -15.47298 21.75183  1.000 44.27841  ? 644 THR   A HG23 1 
ATOM   4127 N N    . GLU   A 1 283 ? 15.01526  -13.07141 19.71558  1.000 29.33370  ? 645 GLU   A N    1 
ATOM   4128 C CA   . GLU   A 1 283 ? 15.85933  -11.94930 19.30852  1.000 33.74634  ? 645 GLU   A CA   1 
ATOM   4129 C C    . GLU   A 1 283 ? 15.07702  -10.64237 19.32047  1.000 32.34994  ? 645 GLU   A C    1 
ATOM   4130 O O    . GLU   A 1 283 ? 15.26964  -9.78659  18.46341  1.000 39.15711  ? 645 GLU   A O    1 
ATOM   4131 C CB   . GLU   A 1 283 ? 16.48324  -12.18430 17.93756  1.000 39.84548  ? 645 GLU   A CB   1 
ATOM   4132 C CG   . GLU   A 1 283 ? 17.30974  -13.45484 17.85164  1.000 43.36365  ? 645 GLU   A CG   1 
ATOM   4133 C CD   . GLU   A 1 283 ? 18.39443  -13.36118 16.79650  1.000 50.38075  ? 645 GLU   A CD   1 
ATOM   4134 O OE1  . GLU   A 1 283 ? 18.07290  -12.97158 15.64733  1.000 48.48103  ? 645 GLU   A OE1  1 
ATOM   4135 O OE2  . GLU   A 1 283 ? 19.56433  -13.67600 17.12036  1.000 58.90605  ? 645 GLU   A OE2  1 
ATOM   4136 H H    . GLU   A 1 283 ? 15.28417  -13.43705 20.44606  1.000 35.21250  ? 645 GLU   A H    1 
ATOM   4137 H HA   . GLU   A 1 283 ? 16.58095  -11.87040 19.95190  1.000 40.50766  ? 645 GLU   A HA   1 
ATOM   4138 H HB2  . GLU   A 1 283 ? 15.77400  -12.24721 17.27884  1.000 47.82663  ? 645 GLU   A HB2  1 
ATOM   4139 H HB3  . GLU   A 1 283 ? 17.06554  -11.43742 17.72780  1.000 47.82663  ? 645 GLU   A HB3  1 
ATOM   4140 H HG2  . GLU   A 1 283 ? 17.73448  -13.61694 18.70851  1.000 52.04843  ? 645 GLU   A HG2  1 
ATOM   4141 H HG3  . GLU   A 1 283 ? 16.72908  -14.19757 17.62341  1.000 52.04843  ? 645 GLU   A HG3  1 
ATOM   4142 N N    . ARG   A 1 284 ? 14.19058  -10.49134 20.30455  1.000 32.26220  ? 646 ARG   A N    1 
ATOM   4143 C CA   . ARG   A 1 284 ? 13.39852  -9.27821  20.49639  1.000 27.93320  ? 646 ARG   A CA   1 
ATOM   4144 C C    . ARG   A 1 284 ? 13.54423  -8.80053  21.94008  1.000 30.86359  ? 646 ARG   A C    1 
ATOM   4145 O O    . ARG   A 1 284 ? 13.62982  -9.61748  22.85548  1.000 25.90205  ? 646 ARG   A O    1 
ATOM   4146 C CB   . ARG   A 1 284 ? 11.89941  -9.52282  20.21723  1.000 30.34090  ? 646 ARG   A CB   1 
ATOM   4147 C CG   . ARG   A 1 284 ? 11.59547  -10.24216 18.93718  1.000 39.00154  ? 646 ARG   A CG   1 
ATOM   4148 C CD   . ARG   A 1 284 ? 12.05489  -9.41440  17.74065  1.000 38.33209  ? 646 ARG   A CD   1 
ATOM   4149 N NE   . ARG   A 1 284 ? 11.57302  -9.94027  16.46619  1.000 49.08862  ? 646 ARG   A NE   1 
ATOM   4150 C CZ   . ARG   A 1 284 ? 10.31337  -9.90184  16.04602  1.000 53.71780  ? 646 ARG   A CZ   1 
ATOM   4151 N NH1  . ARG   A 1 284 ? 9.35709   -9.32634  16.75863  1.000 52.63433  ? 646 ARG   A NH1  1 
ATOM   4152 N NH2  . ARG   A 1 284 ? 10.00891  -10.45217 14.87605  1.000 62.66270  ? 646 ARG   A NH2  1 
ATOM   4153 H H    . ARG   A 1 284 ? 14.02555  -11.09731 20.89206  1.000 38.72670  ? 646 ARG   A H    1 
ATOM   4154 H HA   . ARG   A 1 284 ? 13.72378  -8.59166  19.89327  1.000 33.53189  ? 646 ARG   A HA   1 
ATOM   4155 H HB2  . ARG   A 1 284 ? 11.53624  -10.05544 20.94203  1.000 36.42113  ? 646 ARG   A HB2  1 
ATOM   4156 H HB3  . ARG   A 1 284 ? 11.45102  -8.66349  20.18004  1.000 36.42113  ? 646 ARG   A HB3  1 
ATOM   4157 H HG2  . ARG   A 1 284 ? 12.06204  -11.09246 18.92284  1.000 46.81390  ? 646 ARG   A HG2  1 
ATOM   4158 H HG3  . ARG   A 1 284 ? 10.63914  -10.38722 18.86439  1.000 46.81390  ? 646 ARG   A HG3  1 
ATOM   4159 H HD2  . ARG   A 1 284 ? 11.72037  -8.50893  17.83616  1.000 46.01056  ? 646 ARG   A HD2  1 
ATOM   4160 H HD3  . ARG   A 1 284 ? 13.02452  -9.40880  17.71437  1.000 46.01056  ? 646 ARG   A HD3  1 
ATOM   4161 H HE   . ARG   A 1 284 ? 12.15211  -10.30461 15.94512  1.000 58.91840  ? 646 ARG   A HE   1 
ATOM   4162 H HH11 . ARG   A 1 284 ? 9.54398   -8.96403  17.51587  1.000 63.17325  ? 646 ARG   A HH11 1 
ATOM   4163 H HH12 . ARG   A 1 284 ? 8.54914   -9.31489  16.46421  1.000 63.17325  ? 646 ARG   A HH12 1 
ATOM   4164 H HH21 . ARG   A 1 284 ? 10.62295  -10.82559 14.40371  1.000 75.20730  ? 646 ARG   A HH21 1 
ATOM   4165 H HH22 . ARG   A 1 284 ? 9.19774   -10.43506 14.59090  1.000 75.20730  ? 646 ARG   A HH22 1 
ATOM   4166 N N    . TRP   A 1 285 ? 13.52138  -7.47717  22.13426  1.000 29.39906  ? 647 TRP   A N    1 
ATOM   4167 C CA   . TRP   A 1 285 ? 13.51280  -6.88977  23.46924  1.000 24.14442  ? 647 TRP   A CA   1 
ATOM   4168 C C    . TRP   A 1 285 ? 12.10003  -6.90082  24.04391  1.000 25.21086  ? 647 TRP   A C    1 
ATOM   4169 O O    . TRP   A 1 285 ? 11.10226  -6.72410  23.31920  1.000 24.08268  ? 647 TRP   A O    1 
ATOM   4170 C CB   . TRP   A 1 285 ? 14.06365  -5.45946  23.41943  1.000 25.60804  ? 647 TRP   A CB   1 
ATOM   4171 C CG   . TRP   A 1 285 ? 15.53257  -5.40220  23.06903  1.000 28.65988  ? 647 TRP   A CG   1 
ATOM   4172 C CD1  . TRP   A 1 285 ? 16.06548  -5.34973  21.82186  1.000 32.48962  ? 647 TRP   A CD1  1 
ATOM   4173 C CD2  . TRP   A 1 285 ? 16.64259  -5.40309  23.98046  1.000 27.29031  ? 647 TRP   A CD2  1 
ATOM   4174 N NE1  . TRP   A 1 285 ? 17.43665  -5.34337  21.89285  1.000 32.49292  ? 647 TRP   A NE1  1 
ATOM   4175 C CE2  . TRP   A 1 285 ? 17.81738  -5.35613  23.20862  1.000 34.10833  ? 647 TRP   A CE2  1 
ATOM   4176 C CE3  . TRP   A 1 285 ? 16.75363  -5.43785  25.37248  1.000 29.87239  ? 647 TRP   A CE3  1 
ATOM   4177 C CZ2  . TRP   A 1 285 ? 19.10721  -5.34140  23.78926  1.000 34.45021  ? 647 TRP   A CZ2  1 
ATOM   4178 C CZ3  . TRP   A 1 285 ? 18.02977  -5.44337  25.95495  1.000 28.31358  ? 647 TRP   A CZ3  1 
ATOM   4179 C CH2  . TRP   A 1 285 ? 19.18866  -5.37949  25.15825  1.000 31.15580  ? 647 TRP   A CH2  1 
ATOM   4180 H H    . TRP   A 1 285 ? 13.51044  -6.89606  21.50040  1.000 35.29093  ? 647 TRP   A H    1 
ATOM   4181 H HA   . TRP   A 1 285 ? 14.07938  -7.40795  24.06200  1.000 28.98536  ? 647 TRP   A HA   1 
ATOM   4182 H HB2  . TRP   A 1 285 ? 13.57628  -4.95792  22.74725  1.000 30.74170  ? 647 TRP   A HB2  1 
ATOM   4183 H HB3  . TRP   A 1 285 ? 13.94772  -5.04725  24.28980  1.000 30.74170  ? 647 TRP   A HB3  1 
ATOM   4184 H HD1  . TRP   A 1 285 ? 15.57315  -5.32209  21.03335  1.000 38.99960  ? 647 TRP   A HD1  1 
ATOM   4185 H HE1  . TRP   A 1 285 ? 17.97096  -5.33303  21.21906  1.000 39.00356  ? 647 TRP   A HE1  1 
ATOM   4186 H HE3  . TRP   A 1 285 ? 15.99198  -5.45707  25.90578  1.000 35.85893  ? 647 TRP   A HE3  1 
ATOM   4187 H HZ2  . TRP   A 1 285 ? 19.87250  -5.30713  23.26193  1.000 41.35230  ? 647 TRP   A HZ2  1 
ATOM   4188 H HZ3  . TRP   A 1 285 ? 18.11135  -5.48988  26.88020  1.000 33.98835  ? 647 TRP   A HZ3  1 
ATOM   4189 H HH2  . TRP   A 1 285 ? 20.02386  -5.36282  25.56698  1.000 37.39902  ? 647 TRP   A HH2  1 
ATOM   4190 N N    . PHE   A 1 286 ? 12.00995  -7.14960  25.34591  1.000 23.31676  ? 648 PHE   A N    1 
ATOM   4191 C CA   . PHE   A 1 286 ? 10.72831  -7.11348  26.03750  1.000 21.30888  ? 648 PHE   A CA   1 
ATOM   4192 C C    . PHE   A 1 286 ? 10.85903  -6.33255  27.33150  1.000 24.94039  ? 648 PHE   A C    1 
ATOM   4193 O O    . PHE   A 1 286 ? 11.95331  -6.15780  27.87028  1.000 24.93046  ? 648 PHE   A O    1 
ATOM   4194 C CB   . PHE   A 1 286 ? 10.18794  -8.52433  26.31142  1.000 22.78909  ? 648 PHE   A CB   1 
ATOM   4195 C CG   . PHE   A 1 286 ? 10.99003  -9.30126  27.26603  1.000 24.60874  ? 648 PHE   A CG   1 
ATOM   4196 C CD1  . PHE   A 1 286 ? 10.74990  -9.20384  28.62101  1.000 23.94686  ? 648 PHE   A CD1  1 
ATOM   4197 C CD2  . PHE   A 1 286 ? 11.98824  -10.16410 26.82968  1.000 26.89775  ? 648 PHE   A CD2  1 
ATOM   4198 C CE1  . PHE   A 1 286 ? 11.48707  -9.91069  29.49801  1.000 23.82815  ? 648 PHE   A CE1  1 
ATOM   4199 C CE2  . PHE   A 1 286 ? 12.70706  -10.88413 27.73626  1.000 27.25063  ? 648 PHE   A CE2  1 
ATOM   4200 C CZ   . PHE   A 1 286 ? 12.44179  -10.76076 29.04891  1.000 24.75278  ? 648 PHE   A CZ   1 
ATOM   4201 H H    . PHE   A 1 286 ? 12.67918  -7.34206  25.85057  1.000 27.99216  ? 648 PHE   A H    1 
ATOM   4202 H HA   . PHE   A 1 286 ? 10.08135  -6.65145  25.48174  1.000 25.58271  ? 648 PHE   A HA   1 
ATOM   4203 H HB2  . PHE   A 1 286 ? 9.29143   -8.44819  26.67388  1.000 27.35897  ? 648 PHE   A HB2  1 
ATOM   4204 H HB3  . PHE   A 1 286 ? 10.16722  -9.01626  25.47568  1.000 27.35897  ? 648 PHE   A HB3  1 
ATOM   4205 H HD1  . PHE   A 1 286 ? 10.07367  -8.64565  28.93091  1.000 28.74829  ? 648 PHE   A HD1  1 
ATOM   4206 H HD2  . PHE   A 1 286 ? 12.16533  -10.24996 25.92075  1.000 32.28935  ? 648 PHE   A HD2  1 
ATOM   4207 H HE1  . PHE   A 1 286 ? 11.34113  -9.81559  30.41156  1.000 28.60583  ? 648 PHE   A HE1  1 
ATOM   4208 H HE2  . PHE   A 1 286 ? 13.37893  -11.45900 27.44815  1.000 32.71281  ? 648 PHE   A HE2  1 
ATOM   4209 H HZ   . PHE   A 1 286 ? 12.92341  -11.26924 29.66078  1.000 29.71539  ? 648 PHE   A HZ   1 
ATOM   4210 N N    . VAL   A 1 287 ? 9.72038   -5.88586  27.83992  1.000 24.97283  ? 649 VAL   A N    1 
ATOM   4211 C CA   . VAL   A 1 287 ? 9.69035   -5.08273  29.04999  1.000 28.33586  ? 649 VAL   A CA   1 
ATOM   4212 C C    . VAL   A 1 287 ? 9.54916   -6.03191  30.23538  1.000 29.49280  ? 649 VAL   A C    1 
ATOM   4213 O O    . VAL   A 1 287 ? 8.57126   -6.78028  30.35596  1.000 24.27118  ? 649 VAL   A O    1 
ATOM   4214 C CB   . VAL   A 1 287 ? 8.58918   -4.00452  28.98892  1.000 28.19429  ? 649 VAL   A CB   1 
ATOM   4215 C CG1  . VAL   A 1 287 ? 7.22625   -4.56296  28.62499  1.000 32.34643  ? 649 VAL   A CG1  1 
ATOM   4216 C CG2  . VAL   A 1 287 ? 8.55167   -3.19966  30.32975  1.000 24.10522  ? 649 VAL   A CG2  1 
ATOM   4217 H H    . VAL   A 1 287 ? 8.94557   -6.03648  27.49847  1.000 29.97945  ? 649 VAL   A H    1 
ATOM   4218 H HA   . VAL   A 1 287 ? 10.53317  -4.61564  29.16127  1.000 34.01509  ? 649 VAL   A HA   1 
ATOM   4219 H HB   . VAL   A 1 287 ? 8.81209   -3.39386  28.26899  1.000 33.84520  ? 649 VAL   A HB   1 
ATOM   4220 H HG11 . VAL   A 1 287 ? 6.55450   -3.87959  28.77553  1.000 38.82778  ? 649 VAL   A HG11 1 
ATOM   4221 H HG12 . VAL   A 1 287 ? 7.23056   -4.82235  27.69032  1.000 38.82778  ? 649 VAL   A HG12 1 
ATOM   4222 H HG13 . VAL   A 1 287 ? 7.04261   -5.33567  29.18186  1.000 38.82778  ? 649 VAL   A HG13 1 
ATOM   4223 H HG21 . VAL   A 1 287 ? 7.94220   -2.45140  30.23198  1.000 28.93832  ? 649 VAL   A HG21 1 
ATOM   4224 H HG22 . VAL   A 1 287 ? 8.24604   -3.78451  31.04070  1.000 28.93832  ? 649 VAL   A HG22 1 
ATOM   4225 H HG23 . VAL   A 1 287 ? 9.44405   -2.87562  30.52864  1.000 28.93832  ? 649 VAL   A HG23 1 
ATOM   4226 N N    . GLY   A 1 288 ? 10.59748  -6.07797  31.06747  1.000 29.01308  ? 650 GLY   A N    1 
ATOM   4227 C CA   . GLY   A 1 288 ? 10.56422  -6.85567  32.28186  1.000 23.91241  ? 650 GLY   A CA   1 
ATOM   4228 C C    . GLY   A 1 288 ? 10.13556  -6.03115  33.47957  1.000 29.00117  ? 650 GLY   A C    1 
ATOM   4229 O O    . GLY   A 1 288 ? 9.50628   -6.54742  34.41426  1.000 25.22554  ? 650 GLY   A O    1 
ATOM   4230 H H    . GLY   A 1 288 ? 11.33828  -5.66051  30.93886  1.000 34.82775  ? 650 GLY   A H    1 
ATOM   4231 H HA2  . GLY   A 1 288 ? 9.93969   -7.59030  32.17611  1.000 28.70695  ? 650 GLY   A HA2  1 
ATOM   4232 H HA3  . GLY   A 1 288 ? 11.44783  -7.21518  32.45764  1.000 28.70695  ? 650 GLY   A HA3  1 
ATOM   4233 N N    . GLY   A 1 289 ? 10.45905  -4.74230  33.44059  1.000 24.74018  ? 651 GLY   A N    1 
ATOM   4234 C CA   . GLY   A 1 289 ? 10.20872  -3.87196  34.56643  1.000 23.69701  ? 651 GLY   A CA   1 
ATOM   4235 C C    . GLY   A 1 289 ? 9.74257   -2.50155  34.12253  1.000 22.81259  ? 651 GLY   A C    1 
ATOM   4236 O O    . GLY   A 1 289 ? 9.93735   -2.08779  32.97869  1.000 25.22584  ? 651 GLY   A O    1 
ATOM   4237 H H    . GLY   A 1 289 ? 10.82595  -4.35219  32.76769  1.000 29.70027  ? 651 GLY   A H    1 
ATOM   4238 H HA2  . GLY   A 1 289 ? 9.52382   -4.26217  35.13172  1.000 28.44847  ? 651 GLY   A HA2  1 
ATOM   4239 H HA3  . GLY   A 1 289 ? 11.02310  -3.76796  35.08303  1.000 28.44847  ? 651 GLY   A HA3  1 
ATOM   4240 N N    . ILE   A 1 290 ? 9.10916   -1.81078  35.05966  1.000 24.46105  ? 652 ILE   A N    1 
ATOM   4241 C CA   . ILE   A 1 290 ? 8.76409   -0.40241  34.92440  1.000 26.19863  ? 652 ILE   A CA   1 
ATOM   4242 C C    . ILE   A 1 290 ? 9.52222   0.35458   36.01686  1.000 26.89474  ? 652 ILE   A C    1 
ATOM   4243 O O    . ILE   A 1 290 ? 9.47800   -0.04361  37.18478  1.000 25.77467  ? 652 ILE   A O    1 
ATOM   4244 C CB   . ILE   A 1 290 ? 7.24810   -0.17309  35.05106  1.000 23.62970  ? 652 ILE   A CB   1 
ATOM   4245 C CG1  . ILE   A 1 290 ? 6.45855   -1.01881  34.03738  1.000 27.83485  ? 652 ILE   A CG1  1 
ATOM   4246 C CG2  . ILE   A 1 290 ? 6.87426   1.28959   34.81715  1.000 24.67023  ? 652 ILE   A CG2  1 
ATOM   4247 C CD1  . ILE   A 1 290 ? 4.95514   -1.02179  34.28889  1.000 29.97679  ? 652 ILE   A CD1  1 
ATOM   4248 H H    . ILE   A 1 290 ? 8.85968   -2.14837  35.81025  1.000 29.36532  ? 652 ILE   A H    1 
ATOM   4249 H HA   . ILE   A 1 290 ? 9.04380   -0.07354  34.05578  1.000 31.45041  ? 652 ILE   A HA   1 
ATOM   4250 H HB   . ILE   A 1 290 ? 7.02062   -0.43640  35.95650  1.000 28.36769  ? 652 ILE   A HB   1 
ATOM   4251 H HG12 . ILE   A 1 290 ? 6.61032   -0.66330  33.14773  1.000 33.41387  ? 652 ILE   A HG12 1 
ATOM   4252 H HG13 . ILE   A 1 290 ? 6.76975   -1.93626  34.08558  1.000 33.41387  ? 652 ILE   A HG13 1 
ATOM   4253 H HG21 . ILE   A 1 290 ? 5.92466   1.40270   34.97954  1.000 29.61633  ? 652 ILE   A HG21 1 
ATOM   4254 H HG22 . ILE   A 1 290 ? 7.38278   1.84690   35.42683  1.000 29.61633  ? 652 ILE   A HG22 1 
ATOM   4255 H HG23 . ILE   A 1 290 ? 7.08350   1.52625   33.90003  1.000 29.61633  ? 652 ILE   A HG23 1 
ATOM   4256 H HD11 . ILE   A 1 290 ? 4.54256   -1.69764  33.72862  1.000 35.98420  ? 652 ILE   A HD11 1 
ATOM   4257 H HD12 . ILE   A 1 290 ? 4.79175   -1.22231  35.22377  1.000 35.98420  ? 652 ILE   A HD12 1 
ATOM   4258 H HD13 . ILE   A 1 290 ? 4.59669   -0.14728  34.07061  1.000 35.98420  ? 652 ILE   A HD13 1 
ATOM   4259 N N    . VAL   A 1 291 ? 10.20285  1.44514   35.63626  1.000 23.84843  ? 653 VAL   A N    1 
ATOM   4260 C CA   . VAL   A 1 291 ? 10.88601  2.28264   36.62351  1.000 25.72462  ? 653 VAL   A CA   1 
ATOM   4261 C C    . VAL   A 1 291 ? 9.87013   2.77096   37.63908  1.000 26.89021  ? 653 VAL   A C    1 
ATOM   4262 O O    . VAL   A 1 291 ? 8.95542   3.53156   37.29422  1.000 22.37020  ? 653 VAL   A O    1 
ATOM   4263 C CB   . VAL   A 1 291 ? 11.58316  3.46676   35.95169  1.000 26.22133  ? 653 VAL   A CB   1 
ATOM   4264 C CG1  . VAL   A 1 291 ? 12.21610  4.37576   36.99602  1.000 30.45944  ? 653 VAL   A CG1  1 
ATOM   4265 C CG2  . VAL   A 1 291 ? 12.65837  3.00688   34.97620  1.000 26.44992  ? 653 VAL   A CG2  1 
ATOM   4266 H H    . VAL   A 1 291 ? 10.28156  1.71558   34.82369  1.000 28.63017  ? 653 VAL   A H    1 
ATOM   4267 H HA   . VAL   A 1 291 ? 11.55527  1.74313   37.07286  1.000 30.88160  ? 653 VAL   A HA   1 
ATOM   4268 H HB   . VAL   A 1 291 ? 10.90978  3.95875   35.45631  1.000 31.47765  ? 653 VAL   A HB   1 
ATOM   4269 H HG11 . VAL   A 1 291 ? 12.82249  4.99036   36.55391  1.000 36.56338  ? 653 VAL   A HG11 1 
ATOM   4270 H HG12 . VAL   A 1 291 ? 11.51610  4.87076   37.44977  1.000 36.56338  ? 653 VAL   A HG12 1 
ATOM   4271 H HG13 . VAL   A 1 291 ? 12.70360  3.83187   37.63432  1.000 36.56338  ? 653 VAL   A HG13 1 
ATOM   4272 H HG21 . VAL   A 1 291 ? 13.07154  3.78559   34.57148  1.000 31.75195  ? 653 VAL   A HG21 1 
ATOM   4273 H HG22 . VAL   A 1 291 ? 13.32406  2.49273   35.45931  1.000 31.75195  ? 653 VAL   A HG22 1 
ATOM   4274 H HG23 . VAL   A 1 291 ? 12.24840  2.45622   34.29092  1.000 31.75195  ? 653 VAL   A HG23 1 
ATOM   4275 N N    . SER   A 1 292 ? 10.07485  2.39737   38.90792  1.000 28.52079  ? 654 SER   A N    1 
ATOM   4276 C CA   . SER   A 1 292 ? 9.10933   2.67669   39.97035  1.000 27.21237  ? 654 SER   A CA   1 
ATOM   4277 C C    . SER   A 1 292 ? 9.67847   3.52743   41.09747  1.000 30.90704  ? 654 SER   A C    1 
ATOM   4278 O O    . SER   A 1 292 ? 9.22548   4.66155   41.28595  1.000 31.89277  ? 654 SER   A O    1 
ATOM   4279 C CB   . SER   A 1 292 ? 8.58895   1.34931   40.51256  1.000 23.14456  ? 654 SER   A CB   1 
ATOM   4280 O OG   . SER   A 1 292 ? 7.50070   1.56590   41.37226  1.000 27.06205  ? 654 SER   A OG   1 
ATOM   4281 H H    . SER   A 1 292 ? 10.77398  1.97623   39.17896  1.000 34.23700  ? 654 SER   A H    1 
ATOM   4282 H HA   . SER   A 1 292 ? 8.38896   3.19836   39.58327  1.000 32.66690  ? 654 SER   A HA   1 
ATOM   4283 H HB2  . SER   A 1 292 ? 8.30227   0.79370   39.77094  1.000 27.78552  ? 654 SER   A HB2  1 
ATOM   4284 H HB3  . SER   A 1 292 ? 9.29866   0.90667   41.00377  1.000 27.78552  ? 654 SER   A HB3  1 
ATOM   4285 H HG   . SER   A 1 292 ? 6.89620   1.98802   40.96978  1.000 32.48651  ? 654 SER   A HG   1 
ATOM   4286 N N    . TRP   A 1 293 ? 10.58137  2.99645   41.91406  1.000 23.02787  ? 655 TRP   A N    1 
ATOM   4287 C CA   . TRP   A 1 293 ? 11.09842  3.74079   43.04367  1.000 31.61032  ? 655 TRP   A CA   1 
ATOM   4288 C C    . TRP   A 1 293 ? 12.48746  3.21304   43.35208  1.000 27.61744  ? 655 TRP   A C    1 
ATOM   4289 O O    . TRP   A 1 293 ? 13.03249  2.38262   42.61982  1.000 26.33657  ? 655 TRP   A O    1 
ATOM   4290 C CB   . TRP   A 1 293 ? 10.17470  3.66908   44.25702  1.000 27.98994  ? 655 TRP   A CB   1 
ATOM   4291 C CG   . TRP   A 1 293 ? 9.96225   2.31608   44.80214  1.000 30.25554  ? 655 TRP   A CG   1 
ATOM   4292 C CD1  . TRP   A 1 293 ? 9.18642   1.34155   44.27215  1.000 28.09341  ? 655 TRP   A CD1  1 
ATOM   4293 C CD2  . TRP   A 1 293 ? 10.56750  1.76074   45.98897  1.000 33.29725  ? 655 TRP   A CD2  1 
ATOM   4294 N NE1  . TRP   A 1 293 ? 9.25656   0.19473   45.05735  1.000 28.90090  ? 655 TRP   A NE1  1 
ATOM   4295 C CE2  . TRP   A 1 293 ? 10.08078  0.44627   46.12882  1.000 30.83168  ? 655 TRP   A CE2  1 
ATOM   4296 C CE3  . TRP   A 1 293 ? 11.46901  2.26066   46.95410  1.000 36.82554  ? 655 TRP   A CE3  1 
ATOM   4297 C CZ2  . TRP   A 1 293 ? 10.46034  -0.37802  47.18599  1.000 28.63830  ? 655 TRP   A CZ2  1 
ATOM   4298 C CZ3  . TRP   A 1 293 ? 11.83533  1.44488   48.00511  1.000 34.03221  ? 655 TRP   A CZ3  1 
ATOM   4299 C CH2  . TRP   A 1 293 ? 11.33826  0.13408   48.10918  1.000 32.16929  ? 655 TRP   A CH2  1 
ATOM   4300 H H    . TRP   A 1 293 ? 10.90770  2.20514   41.83073  1.000 27.64550  ? 655 TRP   A H    1 
ATOM   4301 H HA   . TRP   A 1 293 ? 11.16552  4.67653   42.79712  1.000 37.94444  ? 655 TRP   A HA   1 
ATOM   4302 H HB2  . TRP   A 1 293 ? 10.55627  4.21078   44.96544  1.000 33.59998  ? 655 TRP   A HB2  1 
ATOM   4303 H HB3  . TRP   A 1 293 ? 9.30655   4.01912   44.00270  1.000 33.59998  ? 655 TRP   A HB3  1 
ATOM   4304 H HD1  . TRP   A 1 293 ? 8.68037   1.42610   43.49648  1.000 33.72415  ? 655 TRP   A HD1  1 
ATOM   4305 H HE1  . TRP   A 1 293 ? 8.85195   -0.54741  44.89888  1.000 34.69313  ? 655 TRP   A HE1  1 
ATOM   4306 H HE3  . TRP   A 1 293 ? 11.80936  3.12320   46.88276  1.000 44.20270  ? 655 TRP   A HE3  1 
ATOM   4307 H HZ2  . TRP   A 1 293 ? 10.13081  -1.24422  47.26359  1.000 34.37802  ? 655 TRP   A HZ2  1 
ATOM   4308 H HZ3  . TRP   A 1 293 ? 12.41913  1.76676   48.65355  1.000 40.85070  ? 655 TRP   A HZ3  1 
ATOM   4309 H HH2  . TRP   A 1 293 ? 11.61069  -0.39926  48.82068  1.000 38.61521  ? 655 TRP   A HH2  1 
ATOM   4310 N N    . GLY   A 1 294 ? 13.06056  3.76142   44.40931  1.000 31.76058  ? 656 GLY   A N    1 
ATOM   4311 C CA   . GLY   A 1 294 ? 14.40322  3.46030   44.84817  1.000 31.78721  ? 656 GLY   A CA   1 
ATOM   4312 C C    . GLY   A 1 294 ? 14.73626  4.44154   45.95817  1.000 28.70947  ? 656 GLY   A C    1 
ATOM   4313 O O    . GLY   A 1 294 ? 13.85178  5.12467   46.45526  1.000 38.92037  ? 656 GLY   A O    1 
ATOM   4314 H H    . GLY   A 1 294 ? 12.67163  4.33969   44.91323  1.000 38.12476  ? 656 GLY   A H    1 
ATOM   4315 H HA2  . GLY   A 1 294 ? 14.45775  2.55249   45.18551  1.000 38.15670  ? 656 GLY   A HA2  1 
ATOM   4316 H HA3  . GLY   A 1 294 ? 15.03352  3.56437   44.11825  1.000 38.15670  ? 656 GLY   A HA3  1 
ATOM   4317 N N    . SER   A 1 295 ? 16.01081  4.53164   46.32227  1.000 37.24787  ? 657 SER   A N    1 
ATOM   4318 C CA   . SER   A 1 295 ? 16.38318  5.51554   47.34779  1.000 41.23262  ? 657 SER   A CA   1 
ATOM   4319 C C    . SER   A 1 295 ? 16.32688  6.93119   46.78125  1.000 38.57818  ? 657 SER   A C    1 
ATOM   4320 O O    . SER   A 1 295 ? 16.49107  7.14016   45.57686  1.000 37.61114  ? 657 SER   A O    1 
ATOM   4321 C CB   . SER   A 1 295 ? 17.78342  5.23976   47.89400  1.000 47.87954  ? 657 SER   A CB   1 
ATOM   4322 O OG   . SER   A 1 295 ? 18.76078  5.35967   46.87375  1.000 52.78338  ? 657 SER   A OG   1 
ATOM   4323 H H    . SER   A 1 295 ? 16.65581  4.05763   46.00778  1.000 44.70949  ? 657 SER   A H    1 
ATOM   4324 H HA   . SER   A 1 295 ? 15.75670  5.44911   48.08535  1.000 49.49119  ? 657 SER   A HA   1 
ATOM   4325 H HB2  . SER   A 1 295 ? 17.97982  5.88062   48.59515  1.000 57.46750  ? 657 SER   A HB2  1 
ATOM   4326 H HB3  . SER   A 1 295 ? 17.81018  4.33840   48.25138  1.000 57.46750  ? 657 SER   A HB3  1 
ATOM   4327 H HG   . SER   A 1 295 ? 18.85987  6.16707   46.66428  1.000 63.35211  ? 657 SER   A HG   1 
ATOM   4328 N N    . MET   A 1 296 ? 16.10201  7.91744   47.66659  1.000 47.13815  ? 658 MET   A N    1 
ATOM   4329 C CA   . MET   A 1 296 ? 16.07741  9.31551   47.22586  1.000 49.94328  ? 658 MET   A CA   1 
ATOM   4330 C C    . MET   A 1 296 ? 17.42867  9.77599   46.70204  1.000 50.94698  ? 658 MET   A C    1 
ATOM   4331 O O    . MET   A 1 296 ? 17.48527  10.73598  45.93457  1.000 54.90663  ? 658 MET   A O    1 
ATOM   4332 C CB   . MET   A 1 296 ? 15.63718  10.25440  48.35711  1.000 61.83838  ? 658 MET   A CB   1 
ATOM   4333 C CG   . MET   A 1 296 ? 15.04551  11.60753  47.87851  1.000 82.41785  ? 658 MET   A CG   1 
ATOM   4334 S SD   . MET   A 1 296 ? 13.45296  11.48490  46.98793  1.000 93.66618  ? 658 MET   A SD   1 
ATOM   4335 C CE   . MET   A 1 296 ? 13.63623  12.72589  45.69958  1.000 59.98604  ? 658 MET   A CE   1 
ATOM   4336 H H    . MET   A 1 296 ? 15.96437  7.80284   48.50773  1.000 56.57784  ? 658 MET   A H    1 
ATOM   4337 H HA   . MET   A 1 296 ? 15.41386  9.37925   46.52121  1.000 59.94400  ? 658 MET   A HA   1 
ATOM   4338 H HB2  . MET   A 1 296 ? 14.95592  9.80646   48.88260  1.000 74.21811  ? 658 MET   A HB2  1 
ATOM   4339 H HB3  . MET   A 1 296 ? 16.40787  10.45175  48.91208  1.000 74.21811  ? 658 MET   A HB3  1 
ATOM   4340 H HG2  . MET   A 1 296 ? 14.90129  12.17135  48.65453  1.000 98.91348  ? 658 MET   A HG2  1 
ATOM   4341 H HG3  . MET   A 1 296 ? 15.68218  12.02597  47.27813  1.000 98.91348  ? 658 MET   A HG3  1 
ATOM   4342 H HE1  . MET   A 1 296 ? 12.83578  12.73295  45.15174  1.000 71.99531  ? 658 MET   A HE1  1 
ATOM   4343 H HE2  . MET   A 1 296 ? 13.76169  13.59430  46.11314  1.000 71.99531  ? 658 MET   A HE2  1 
ATOM   4344 H HE3  . MET   A 1 296 ? 14.40778  12.50426  45.15508  1.000 71.99531  ? 658 MET   A HE3  1 
ATOM   4345 N N    . ASN   A 1 297 ? 18.50938  9.10436   47.07830  1.000 53.33410  ? 659 ASN   A N    1 
ATOM   4346 C CA   . ASN   A 1 297 ? 19.83213  9.35791   46.51646  1.000 54.42101  ? 659 ASN   A CA   1 
ATOM   4347 C C    . ASN   A 1 297 ? 20.04740  8.34946   45.40443  1.000 50.88978  ? 659 ASN   A C    1 
ATOM   4348 O O    . ASN   A 1 297 ? 20.36210  7.18507   45.65931  1.000 47.15080  ? 659 ASN   A O    1 
ATOM   4349 C CB   . ASN   A 1 297 ? 20.90361  9.25799   47.59060  1.000 48.11999  ? 659 ASN   A CB   1 
ATOM   4350 C CG   . ASN   A 1 297 ? 20.53578  10.03604  48.81899  1.000 54.33849  ? 659 ASN   A CG   1 
ATOM   4351 O OD1  . ASN   A 1 297 ? 20.82738  11.22248  48.91652  1.000 49.78824  ? 659 ASN   A OD1  1 
ATOM   4352 N ND2  . ASN   A 1 297 ? 19.87788  9.37200   49.76708  1.000 63.35416  ? 659 ASN   A ND2  1 
ATOM   4353 H H    . ASN   A 1 297 ? 18.50271  8.48185   47.67162  1.000 64.01297  ? 659 ASN   A H    1 
ATOM   4354 H HA   . ASN   A 1 297 ? 19.86932  10.25151  46.14096  1.000 65.31727  ? 659 ASN   A HA   1 
ATOM   4355 H HB2  . ASN   A 1 297 ? 21.01793  8.32830   47.84263  1.000 57.75605  ? 659 ASN   A HB2  1 
ATOM   4356 H HB3  . ASN   A 1 297 ? 21.73738  9.61282   47.24445  1.000 57.75605  ? 659 ASN   A HB3  1 
ATOM   4357 H HD21 . ASN   A 1 297 ? 19.68622  8.54103   49.65592  1.000 76.03704  ? 659 ASN   A HD21 1 
ATOM   4358 H HD22 . ASN   A 1 297 ? 19.64458  9.77404   50.49063  1.000 76.03704  ? 659 ASN   A HD22 1 
ATOM   4359 N N    . CYS   A 1 298 ? 19.86307  8.79993   44.16878  1.000 47.83245  ? 660 CYS   A N    1 
ATOM   4360 C CA   . CYS   A 1 298 ? 20.02976  7.90718   43.04044  1.000 43.19374  ? 660 CYS   A CA   1 
ATOM   4361 C C    . CYS   A 1 298 ? 21.46433  7.40144   42.97105  1.000 46.69284  ? 660 CYS   A C    1 
ATOM   4362 O O    . CYS   A 1 298 ? 22.41481  8.15430   43.20599  1.000 46.78833  ? 660 CYS   A O    1 
ATOM   4363 C CB   . CYS   A 1 298 ? 19.66667  8.62132   41.74708  1.000 42.64070  ? 660 CYS   A CB   1 
ATOM   4364 S SG   . CYS   A 1 298 ? 19.54096  7.42950   40.47222  1.000 57.21406  ? 660 CYS   A SG   1 
ATOM   4365 H H    . CYS   A 1 298 ? 19.64460  9.60611   43.96401  1.000 57.41099  ? 660 CYS   A H    1 
ATOM   4366 H HA   . CYS   A 1 298 ? 19.43919  7.14456   43.14312  1.000 51.84455  ? 660 CYS   A HA   1 
ATOM   4367 H HB2  . CYS   A 1 298 ? 18.81407  9.07329   41.84554  1.000 51.18089  ? 660 CYS   A HB2  1 
ATOM   4368 H HB3  . CYS   A 1 298 ? 20.35729  9.26230   41.51667  1.000 51.18089  ? 660 CYS   A HB3  1 
ATOM   4369 N N    . GLY   A 1 299 ? 21.61721  6.11516   42.64105  1.000 41.24894  ? 661 GLY   A N    1 
ATOM   4370 C CA   . GLY   A 1 299 ? 22.94076  5.53836   42.47290  1.000 44.85143  ? 661 GLY   A CA   1 
ATOM   4371 C C    . GLY   A 1 299 ? 23.68790  5.29621   43.76765  1.000 51.18504  ? 661 GLY   A C    1 
ATOM   4372 O O    . GLY   A 1 299 ? 24.89978  5.07340   43.74585  1.000 48.22698  ? 661 GLY   A O    1 
ATOM   4373 H H    . GLY   A 1 299 ? 20.97033  5.56358   42.51098  1.000 49.51079  ? 661 GLY   A H    1 
ATOM   4374 H HA2  . GLY   A 1 299 ? 22.85463  4.68742   42.01532  1.000 53.83378  ? 661 GLY   A HA2  1 
ATOM   4375 H HA3  . GLY   A 1 299 ? 23.47534  6.13711   41.92827  1.000 53.83378  ? 661 GLY   A HA3  1 
ATOM   4376 N N    . GLU   A 1 300 ? 23.00277  5.33153   44.89925  1.000 48.48598  ? 662 GLU   A N    1 
ATOM   4377 C CA   . GLU   A 1 300 ? 23.64972  5.07425   46.17410  1.000 57.85451  ? 662 GLU   A CA   1 
ATOM   4378 C C    . GLU   A 1 300 ? 24.03711  3.59902   46.26900  1.000 56.00642  ? 662 GLU   A C    1 
ATOM   4379 O O    . GLU   A 1 300 ? 23.31753  2.71267   45.80320  1.000 39.91496  ? 662 GLU   A O    1 
ATOM   4380 C CB   . GLU   A 1 300 ? 22.70833  5.48340   47.31022  1.000 60.75929  ? 662 GLU   A CB   1 
ATOM   4381 C CG   . GLU   A 1 300 ? 22.81855  4.68391   48.59076  1.000 63.98904  ? 662 GLU   A CG   1 
ATOM   4382 C CD   . GLU   A 1 300 ? 22.28544  5.44998   49.79662  1.000 64.12372  ? 662 GLU   A CD   1 
ATOM   4383 O OE1  . GLU   A 1 300 ? 21.10806  5.88301   49.75313  1.000 65.27067  ? 662 GLU   A OE1  1 
ATOM   4384 O OE2  . GLU   A 1 300 ? 23.04191  5.62637   50.77549  1.000 65.01701  ? 662 GLU   A OE2  1 
ATOM   4385 H H    . GLU   A 1 300 ? 22.16182  5.50211   44.95672  1.000 58.19523  ? 662 GLU   A H    1 
ATOM   4386 H HA   . GLU   A 1 300 ? 24.46316  5.59488   46.26446  1.000 69.43746  ? 662 GLU   A HA   1 
ATOM   4387 H HB2  . GLU   A 1 300 ? 22.89052  6.40923   47.53503  1.000 72.92320  ? 662 GLU   A HB2  1 
ATOM   4388 H HB3  . GLU   A 1 300 ? 21.79579  5.39212   46.99423  1.000 72.92320  ? 662 GLU   A HB3  1 
ATOM   4389 H HG2  . GLU   A 1 300 ? 22.30433  3.86637   48.50067  1.000 76.79890  ? 662 GLU   A HG2  1 
ATOM   4390 H HG3  . GLU   A 1 300 ? 23.75100  4.47296   48.75487  1.000 76.79890  ? 662 GLU   A HG3  1 
ATOM   4391 N N    . ALA   A 1 301 ? 25.18869  3.34415   46.88502  1.000 57.35055  ? 663 ALA   A N    1 
ATOM   4392 C CA   . ALA   A 1 301 ? 25.65093  1.98409   47.11246  1.000 55.24511  ? 663 ALA   A CA   1 
ATOM   4393 C C    . ALA   A 1 301 ? 24.63123  1.18027   47.91054  1.000 54.36518  ? 663 ALA   A C    1 
ATOM   4394 O O    . ALA   A 1 301 ? 24.10398  1.64832   48.92379  1.000 54.87552  ? 663 ALA   A O    1 
ATOM   4395 C CB   . ALA   A 1 301 ? 26.98518  2.01564   47.85799  1.000 47.51610  ? 663 ALA   A CB   1 
ATOM   4396 H H    . ALA   A 1 301 ? 25.72395  3.94786   47.18272  1.000 68.83272  ? 663 ALA   A H    1 
ATOM   4397 H HA   . ALA   A 1 301 ? 25.77312  1.54455   46.25644  1.000 66.30619  ? 663 ALA   A HA   1 
ATOM   4398 H HB1  . ALA   A 1 301 ? 27.31675  1.10878   47.95052  1.000 57.03138  ? 663 ALA   A HB1  1 
ATOM   4399 H HB2  . ALA   A 1 301 ? 27.61748  2.54895   47.35135  1.000 57.03138  ? 663 ALA   A HB2  1 
ATOM   4400 H HB3  . ALA   A 1 301 ? 26.84817  2.40875   48.73411  1.000 57.03138  ? 663 ALA   A HB3  1 
ATOM   4401 N N    . GLY   A 1 302 ? 24.35265  -0.03336  47.44412  1.000 51.77805  ? 664 GLY   A N    1 
ATOM   4402 C CA   . GLY   A 1 302 ? 23.48800  -0.95561  48.15301  1.000 55.03824  ? 664 GLY   A CA   1 
ATOM   4403 C C    . GLY   A 1 302 ? 22.00362  -0.65848  48.10885  1.000 52.03165  ? 664 GLY   A C    1 
ATOM   4404 O O    . GLY   A 1 302 ? 21.23077  -1.42511  48.69661  1.000 51.83431  ? 664 GLY   A O    1 
ATOM   4405 H H    . GLY   A 1 302 ? 24.66020  -0.34761  46.70503  1.000 62.14571  ? 664 GLY   A H    1 
ATOM   4406 H HA2  . GLY   A 1 302 ? 23.61660  -1.84142  47.77925  1.000 66.05794  ? 664 GLY   A HA2  1 
ATOM   4407 H HA3  . GLY   A 1 302 ? 23.75316  -0.96498  49.08602  1.000 66.05794  ? 664 GLY   A HA3  1 
ATOM   4408 N N    . GLN   A 1 303 ? 21.57151  0.41525   47.44117  1.000 44.58375  ? 665 GLN   A N    1 
ATOM   4409 C CA   . GLN   A 1 303 ? 20.16741  0.82455   47.40796  1.000 42.79269  ? 665 GLN   A CA   1 
ATOM   4410 C C    . GLN   A 1 303 ? 19.72913  0.70258   45.95248  1.000 46.64921  ? 665 GLN   A C    1 
ATOM   4411 O O    . GLN   A 1 303 ? 19.89202  1.61394   45.13179  1.000 43.80403  ? 665 GLN   A O    1 
ATOM   4412 C CB   . GLN   A 1 303 ? 19.95380  2.24438   47.96703  1.000 53.56976  ? 665 GLN   A CB   1 
ATOM   4413 C CG   . GLN   A 1 303 ? 20.40077  2.40093   49.44229  1.000 57.87246  ? 665 GLN   A CG   1 
ATOM   4414 C CD   . GLN   A 1 303 ? 19.45636  1.76613   50.43497  1.000 58.03267  ? 665 GLN   A CD   1 
ATOM   4415 O OE1  . GLN   A 1 303 ? 18.25363  1.68902   50.20011  1.000 51.82049  ? 665 GLN   A OE1  1 
ATOM   4416 N NE2  . GLN   A 1 303 ? 20.00117  1.30307   51.56056  1.000 56.71394  ? 665 GLN   A NE2  1 
ATOM   4417 H H    . GLN   A 1 303 ? 22.08783  0.93373   46.98929  1.000 53.51255  ? 665 GLN   A H    1 
ATOM   4418 H HA   . GLN   A 1 303 ? 19.63887  0.22914   47.96207  1.000 51.36329  ? 665 GLN   A HA   1 
ATOM   4419 H HB2  . GLN   A 1 303 ? 20.46636  2.87125   47.43298  1.000 64.29576  ? 665 GLN   A HB2  1 
ATOM   4420 H HB3  . GLN   A 1 303 ? 19.00961  2.46116   47.91787  1.000 64.29576  ? 665 GLN   A HB3  1 
ATOM   4421 H HG2  . GLN   A 1 303 ? 21.26922  1.98286   49.55144  1.000 69.45901  ? 665 GLN   A HG2  1 
ATOM   4422 H HG3  . GLN   A 1 303 ? 20.45886  3.34615   49.65229  1.000 69.45901  ? 665 GLN   A HG3  1 
ATOM   4423 H HE21 . GLN   A 1 303 ? 20.84843  1.37480   51.68940  1.000 68.06878  ? 665 GLN   A HE21 1 
ATOM   4424 H HE22 . GLN   A 1 303 ? 19.50527  0.93271   52.15765  1.000 68.06878  ? 665 GLN   A HE22 1 
ATOM   4425 N N    . TYR   A 1 304 ? 19.15518  -0.44573  45.65381  1.000 37.96803  ? 666 TYR   A N    1 
ATOM   4426 C CA   . TYR   A 1 304 ? 18.93005  -0.87558  44.28961  1.000 34.94269  ? 666 TYR   A CA   1 
ATOM   4427 C C    . TYR   A 1 304 ? 17.69539  -0.19579  43.72486  1.000 32.97347  ? 666 TYR   A C    1 
ATOM   4428 O O    . TYR   A 1 304 ? 16.78476  0.20419   44.45966  1.000 30.70446  ? 666 TYR   A O    1 
ATOM   4429 C CB   . TYR   A 1 304 ? 18.76456  -2.39090  44.26333  1.000 33.28559  ? 666 TYR   A CB   1 
ATOM   4430 C CG   . TYR   A 1 304 ? 19.82323  -3.14168  45.07604  1.000 36.82652  ? 666 TYR   A CG   1 
ATOM   4431 C CD1  . TYR   A 1 304 ? 21.05288  -3.42729  44.52772  1.000 34.46735  ? 666 TYR   A CD1  1 
ATOM   4432 C CD2  . TYR   A 1 304 ? 19.59692  -3.51792  46.39939  1.000 33.00859  ? 666 TYR   A CD2  1 
ATOM   4433 C CE1  . TYR   A 1 304 ? 22.02875  -4.09930  45.24785  1.000 42.92689  ? 666 TYR   A CE1  1 
ATOM   4434 C CE2  . TYR   A 1 304 ? 20.57563  -4.18440  47.13808  1.000 35.51198  ? 666 TYR   A CE2  1 
ATOM   4435 C CZ   . TYR   A 1 304 ? 21.78977  -4.46031  46.55280  1.000 42.62245  ? 666 TYR   A CZ   1 
ATOM   4436 O OH   . TYR   A 1 304 ? 22.77293  -5.11891  47.24102  1.000 46.28031  ? 666 TYR   A OH   1 
ATOM   4437 H H    . TYR   A 1 304 ? 18.87857  -1.01116  46.23979  1.000 45.57368  ? 666 TYR   A H    1 
ATOM   4438 H HA   . TYR   A 1 304 ? 19.68179  -0.63846  43.72432  1.000 41.94328  ? 666 TYR   A HA   1 
ATOM   4439 H HB2  . TYR   A 1 304 ? 17.89523  -2.61600  44.63006  1.000 39.95476  ? 666 TYR   A HB2  1 
ATOM   4440 H HB3  . TYR   A 1 304 ? 18.82592  -2.69535  43.34439  1.000 39.95476  ? 666 TYR   A HB3  1 
ATOM   4441 H HD1  . TYR   A 1 304 ? 21.23332  -3.16354  43.65435  1.000 41.37287  ? 666 TYR   A HD1  1 
ATOM   4442 H HD2  . TYR   A 1 304 ? 18.77943  -3.32129  46.79680  1.000 39.62236  ? 666 TYR   A HD2  1 
ATOM   4443 H HE1  . TYR   A 1 304 ? 22.84322  -4.30540  44.84902  1.000 51.52433  ? 666 TYR   A HE1  1 
ATOM   4444 H HE2  . TYR   A 1 304 ? 20.40884  -4.43934  48.01677  1.000 42.62644  ? 666 TYR   A HE2  1 
ATOM   4445 H HH   . TYR   A 1 304 ? 22.50840  -5.29953  48.01755  1.000 55.54842  ? 666 TYR   A HH   1 
ATOM   4446 N N    . GLY   A 1 305 ? 17.67050  -0.04700  42.40675  1.000 31.48482  ? 667 GLY   A N    1 
ATOM   4447 C CA   . GLY   A 1 305 ? 16.45412  0.41461   41.76514  1.000 29.63089  ? 667 GLY   A CA   1 
ATOM   4448 C C    . GLY   A 1 305 ? 15.38404  -0.64514  41.91187  1.000 28.12140  ? 667 GLY   A C    1 
ATOM   4449 O O    . GLY   A 1 305 ? 15.66197  -1.84850  41.84472  1.000 25.65068  ? 667 GLY   A O    1 
ATOM   4450 H H    . GLY   A 1 305 ? 18.32878  -0.20305  41.87579  1.000 37.79384  ? 667 GLY   A H    1 
ATOM   4451 H HA2  . GLY   A 1 305 ? 16.14871  1.23639   42.18023  1.000 35.56912  ? 667 GLY   A HA2  1 
ATOM   4452 H HA3  . GLY   A 1 305 ? 16.61488  0.57770   40.82256  1.000 35.56912  ? 667 GLY   A HA3  1 
ATOM   4453 N N    . VAL   A 1 306 ? 14.14863  -0.19424  42.14222  1.000 26.25316  ? 668 VAL   A N    1 
ATOM   4454 C CA   . VAL   A 1 306 ? 12.99494  -1.08172  42.29878  1.000 24.87735  ? 668 VAL   A CA   1 
ATOM   4455 C C    . VAL   A 1 306 ? 12.02210  -0.84511  41.15814  1.000 29.39123  ? 668 VAL   A C    1 
ATOM   4456 O O    . VAL   A 1 306 ? 11.62135  0.29420   40.89619  1.000 26.49396  ? 668 VAL   A O    1 
ATOM   4457 C CB   . VAL   A 1 306 ? 12.28916  -0.88765  43.64940  1.000 26.23050  ? 668 VAL   A CB   1 
ATOM   4458 C CG1  . VAL   A 1 306 ? 11.33153  -2.00203  43.89182  1.000 29.50886  ? 668 VAL   A CG1  1 
ATOM   4459 C CG2  . VAL   A 1 306 ? 13.34567  -0.83606  44.74572  1.000 27.21142  ? 668 VAL   A CG2  1 
ATOM   4460 H H    . VAL   A 1 306 ? 13.95079  0.63968   42.21319  1.000 31.51584  ? 668 VAL   A H    1 
ATOM   4461 H HA   . VAL   A 1 306 ? 13.31140  -1.99701  42.24395  1.000 29.86487  ? 668 VAL   A HA   1 
ATOM   4462 H HB   . VAL   A 1 306 ? 11.78430  -0.05940  43.65210  1.000 31.48865  ? 668 VAL   A HB   1 
ATOM   4463 H HG11 . VAL   A 1 306 ? 10.97020  -1.91855  44.78813  1.000 35.42268  ? 668 VAL   A HG11 1 
ATOM   4464 H HG12 . VAL   A 1 306 ? 10.61495  -1.95003  43.24013  1.000 35.42268  ? 668 VAL   A HG12 1 
ATOM   4465 H HG13 . VAL   A 1 306 ? 11.80021  -2.84646  43.80144  1.000 35.42268  ? 668 VAL   A HG13 1 
ATOM   4466 H HG21 . VAL   A 1 306 ? 12.91162  -0.93524  45.60750  1.000 32.66576  ? 668 VAL   A HG21 1 
ATOM   4467 H HG22 . VAL   A 1 306 ? 13.97830  -1.55852  44.60889  1.000 32.66576  ? 668 VAL   A HG22 1 
ATOM   4468 H HG23 . VAL   A 1 306 ? 13.80412  0.01768   44.70257  1.000 32.66576  ? 668 VAL   A HG23 1 
ATOM   4469 N N    . TYR   A 1 307 ? 11.61210  -1.94195  40.50810  1.000 23.76636  ? 669 TYR   A N    1 
ATOM   4470 C CA   . TYR   A 1 307 ? 10.88752  -1.90425  39.25235  1.000 23.96150  ? 669 TYR   A CA   1 
ATOM   4471 C C    . TYR   A 1 307 ? 9.63124   -2.74188  39.39944  1.000 23.73267  ? 669 TYR   A C    1 
ATOM   4472 O O    . TYR   A 1 307 ? 9.67701   -3.82162  39.97869  1.000 25.22277  ? 669 TYR   A O    1 
ATOM   4473 C CB   . TYR   A 1 307 ? 11.77407  -2.43813  38.13873  1.000 25.07717  ? 669 TYR   A CB   1 
ATOM   4474 C CG   . TYR   A 1 307 ? 13.03458  -1.62803  37.93334  1.000 23.51459  ? 669 TYR   A CG   1 
ATOM   4475 C CD1  . TYR   A 1 307 ? 14.12184  -1.74864  38.78550  1.000 26.28415  ? 669 TYR   A CD1  1 
ATOM   4476 C CD2  . TYR   A 1 307 ? 13.12841  -0.72986  36.89010  1.000 23.80559  ? 669 TYR   A CD2  1 
ATOM   4477 C CE1  . TYR   A 1 307 ? 15.26402  -0.97982  38.60011  1.000 26.27789  ? 669 TYR   A CE1  1 
ATOM   4478 C CE2  . TYR   A 1 307 ? 14.25750  0.01468   36.67973  1.000 23.25969  ? 669 TYR   A CE2  1 
ATOM   4479 C CZ   . TYR   A 1 307 ? 15.32134  -0.10495  37.55244  1.000 24.99263  ? 669 TYR   A CZ   1 
ATOM   4480 O OH   . TYR   A 1 307 ? 16.43547  0.64668   37.35705  1.000 26.54341  ? 669 TYR   A OH   1 
ATOM   4481 H H    . TYR   A 1 307 ? 11.75126  -2.74166  40.79217  1.000 28.53169  ? 669 TYR   A H    1 
ATOM   4482 H HA   . TYR   A 1 307 ? 10.61448  -1.00309  39.01941  1.000 28.76585  ? 669 TYR   A HA   1 
ATOM   4483 H HB2  . TYR   A 1 307 ? 12.03621  -3.34655  38.35541  1.000 30.10466  ? 669 TYR   A HB2  1 
ATOM   4484 H HB3  . TYR   A 1 307 ? 11.27412  -2.42640  37.30758  1.000 30.10466  ? 669 TYR   A HB3  1 
ATOM   4485 H HD1  . TYR   A 1 307 ? 14.08591  -2.35302  39.49143  1.000 31.55304  ? 669 TYR   A HD1  1 
ATOM   4486 H HD2  . TYR   A 1 307 ? 12.40514  -0.62763  36.31449  1.000 28.57876  ? 669 TYR   A HD2  1 
ATOM   4487 H HE1  . TYR   A 1 307 ? 15.98332  -1.06002  39.18412  1.000 31.54552  ? 669 TYR   A HE1  1 
ATOM   4488 H HE2  . TYR   A 1 307 ? 14.30791  0.59598   35.95555  1.000 27.92368  ? 669 TYR   A HE2  1 
ATOM   4489 H HH   . TYR   A 1 307 ? 17.03392  0.42018   37.90125  1.000 31.86415  ? 669 TYR   A HH   1 
ATOM   4490 N N    . THR   A 1 308 ? 8.50717   -2.22667  38.91284  1.000 25.56337  ? 670 THR   A N    1 
ATOM   4491 C CA   . THR   A 1 308 ? 7.29140   -3.02635  38.86466  1.000 22.86180  ? 670 THR   A CA   1 
ATOM   4492 C C    . THR   A 1 308 ? 7.53942   -4.22832  37.98543  1.000 26.50512  ? 670 THR   A C    1 
ATOM   4493 O O    . THR   A 1 308 ? 8.12506   -4.11217  36.91262  1.000 24.37933  ? 670 THR   A O    1 
ATOM   4494 C CB   . THR   A 1 308 ? 6.10844   -2.20141  38.34844  1.000 24.07132  ? 670 THR   A CB   1 
ATOM   4495 O OG1  . THR   A 1 308 ? 6.05445   -0.99296  39.10378  1.000 26.02062  ? 670 THR   A OG1  1 
ATOM   4496 C CG2  . THR   A 1 308 ? 4.77995   -2.96005  38.49588  1.000 24.59045  ? 670 THR   A CG2  1 
ATOM   4497 H H    . THR   A 1 308 ? 8.42368   -1.42673  38.60832  1.000 30.68809  ? 670 THR   A H    1 
ATOM   4498 H HA   . THR   A 1 308 ? 7.05072   -3.32281  39.75633  1.000 27.44622  ? 670 THR   A HA   1 
ATOM   4499 H HB   . THR   A 1 308 ? 6.22313   -2.01385  37.40368  1.000 28.89764  ? 670 THR   A HB   1 
ATOM   4500 H HG1  . THR   A 1 308 ? 5.42789   -0.50777  38.82518  1.000 31.23680  ? 670 THR   A HG1  1 
ATOM   4501 H HG21 . THR   A 1 308 ? 4.03734   -2.37273  38.28495  1.000 29.52059  ? 670 THR   A HG21 1 
ATOM   4502 H HG22 . THR   A 1 308 ? 4.76248   -3.71894  37.89199  1.000 29.52059  ? 670 THR   A HG22 1 
ATOM   4503 H HG23 . THR   A 1 308 ? 4.67973   -3.27975  39.40618  1.000 29.52059  ? 670 THR   A HG23 1 
ATOM   4504 N N    . LYS   A 1 309 ? 7.14719   -5.39221  38.47306  1.000 24.53331  ? 671 LYS   A N    1 
ATOM   4505 C CA   . LYS   A 1 309 ? 7.45976   -6.65318  37.80228  1.000 24.32753  ? 671 LYS   A CA   1 
ATOM   4506 C C    . LYS   A 1 309 ? 6.37448   -6.93954  36.77276  1.000 23.55730  ? 671 LYS   A C    1 
ATOM   4507 O O    . LYS   A 1 309 ? 5.29903   -7.41354  37.11140  1.000 28.24187  ? 671 LYS   A O    1 
ATOM   4508 C CB   . LYS   A 1 309 ? 7.57939   -7.77702  38.82021  1.000 26.31266  ? 671 LYS   A CB   1 
ATOM   4509 C CG   . LYS   A 1 309 ? 8.34194   -8.97308  38.24891  1.000 30.18460  ? 671 LYS   A CG   1 
ATOM   4510 C CD   . LYS   A 1 309 ? 8.85468   -9.92144  39.32746  1.000 41.81126  ? 671 LYS   A CD   1 
ATOM   4511 C CE   . LYS   A 1 309 ? 7.94154   -11.07922 39.54683  1.000 43.15202  ? 671 LYS   A CE   1 
ATOM   4512 N NZ   . LYS   A 1 309 ? 8.22828   -12.19026 38.61856  1.000 52.18712  ? 671 LYS   A NZ   1 
ATOM   4513 H H    . LYS   A 1 309 ? 6.69393   -5.48438  39.19808  1.000 29.45202  ? 671 LYS   A H    1 
ATOM   4514 H HA   . LYS   A 1 309 ? 8.30377   -6.56788  37.33189  1.000 29.20509  ? 671 LYS   A HA   1 
ATOM   4515 H HB2  . LYS   A 1 309 ? 8.05778   -7.45369  39.59963  1.000 31.58724  ? 671 LYS   A HB2  1 
ATOM   4516 H HB3  . LYS   A 1 309 ? 6.69191   -8.07404  39.07526  1.000 31.58724  ? 671 LYS   A HB3  1 
ATOM   4517 H HG2  . LYS   A 1 309 ? 7.75108   -9.47510  37.66601  1.000 36.23358  ? 671 LYS   A HG2  1 
ATOM   4518 H HG3  . LYS   A 1 309 ? 9.10664   -8.64971  37.74734  1.000 36.23358  ? 671 LYS   A HG3  1 
ATOM   4519 H HD2  . LYS   A 1 309 ? 9.72079   -10.26744 39.06092  1.000 50.18557  ? 671 LYS   A HD2  1 
ATOM   4520 H HD3  . LYS   A 1 309 ? 8.93396   -9.43775  40.16451  1.000 50.18557  ? 671 LYS   A HD3  1 
ATOM   4521 H HE2  . LYS   A 1 309 ? 8.05143   -11.40556 40.45365  1.000 51.79448  ? 671 LYS   A HE2  1 
ATOM   4522 H HE3  . LYS   A 1 309 ? 7.02506   -10.79466 39.40543  1.000 51.79448  ? 671 LYS   A HE3  1 
ATOM   4523 H HZ1  . LYS   A 1 309 ? 7.65366   -12.85623 38.75418  1.000 62.63660  ? 671 LYS   A HZ1  1 
ATOM   4524 H HZ2  . LYS   A 1 309 ? 8.15314   -11.91082 37.77691  1.000 62.63660  ? 671 LYS   A HZ2  1 
ATOM   4525 H HZ3  . LYS   A 1 309 ? 9.05546   -12.49116 38.75023  1.000 62.63660  ? 671 LYS   A HZ3  1 
ATOM   4526 N N    . VAL   A 1 310 ? 6.65897   -6.65120  35.49931  1.000 25.80395  ? 672 VAL   A N    1 
ATOM   4527 C CA   . VAL   A 1 310 ? 5.58360   -6.59050  34.50545  1.000 24.56612  ? 672 VAL   A CA   1 
ATOM   4528 C C    . VAL   A 1 310 ? 4.95783   -7.95389  34.26943  1.000 26.03251  ? 672 VAL   A C    1 
ATOM   4529 O O    . VAL   A 1 310 ? 3.76817   -8.04074  33.95146  1.000 28.24849  ? 672 VAL   A O    1 
ATOM   4530 C CB   . VAL   A 1 310 ? 6.13011   -5.96343  33.21124  1.000 24.69236  ? 672 VAL   A CB   1 
ATOM   4531 C CG1  . VAL   A 1 310 ? 5.12002   -6.06935  32.02529  1.000 28.84725  ? 672 VAL   A CG1  1 
ATOM   4532 C CG2  . VAL   A 1 310 ? 6.45926   -4.50464  33.49338  1.000 21.49462  ? 672 VAL   A CG2  1 
ATOM   4533 H H    . VAL   A 1 310 ? 7.44597   -6.49063  35.19197  1.000 30.97680  ? 672 VAL   A H    1 
ATOM   4534 H HA   . VAL   A 1 310 ? 4.87273   -6.02503  34.84577  1.000 29.49140  ? 672 VAL   A HA   1 
ATOM   4535 H HB   . VAL   A 1 310 ? 6.92447   -6.44748  32.93631  1.000 29.64289  ? 672 VAL   A HB   1 
ATOM   4536 H HG11 . VAL   A 1 310 ? 5.40965   -5.48130  31.31031  1.000 34.62875  ? 672 VAL   A HG11 1 
ATOM   4537 H HG12 . VAL   A 1 310 ? 5.09758   -6.98660  31.71055  1.000 34.62875  ? 672 VAL   A HG12 1 
ATOM   4538 H HG13 . VAL   A 1 310 ? 4.23994   -5.80444  32.33543  1.000 34.62875  ? 672 VAL   A HG13 1 
ATOM   4539 H HG21 . VAL   A 1 310 ? 6.64293   -4.05432  32.65411  1.000 25.80560  ? 672 VAL   A HG21 1 
ATOM   4540 H HG22 . VAL   A 1 310 ? 5.70086   -4.08904  33.93271  1.000 25.80560  ? 672 VAL   A HG22 1 
ATOM   4541 H HG23 . VAL   A 1 310 ? 7.23889   -4.46242  34.06896  1.000 25.80560  ? 672 VAL   A HG23 1 
ATOM   4542 N N    . ILE   A 1 311 ? 5.73190   -9.03504  34.39591  1.000 21.93369  ? 673 ILE   A N    1 
ATOM   4543 C CA   . ILE   A 1 311 ? 5.18929   -10.34753 34.07213  1.000 25.06730  ? 673 ILE   A CA   1 
ATOM   4544 C C    . ILE   A 1 311 ? 4.03699   -10.70371 34.99913  1.000 24.87320  ? 673 ILE   A C    1 
ATOM   4545 O O    . ILE   A 1 311 ? 3.10405   -11.37014 34.57954  1.000 24.19345  ? 673 ILE   A O    1 
ATOM   4546 C CB   . ILE   A 1 311 ? 6.29645   -11.43060 34.07287  1.000 28.37218  ? 673 ILE   A CB   1 
ATOM   4547 C CG1  . ILE   A 1 311 ? 5.89453   -12.62626 33.19513  1.000 33.98264  ? 673 ILE   A CG1  1 
ATOM   4548 C CG2  . ILE   A 1 311 ? 6.62650   -11.91374 35.49224  1.000 34.64163  ? 673 ILE   A CG2  1 
ATOM   4549 C CD1  . ILE   A 1 311 ? 7.02457   -13.24008 32.41253  1.000 41.87448  ? 673 ILE   A CD1  1 
ATOM   4550 H H    . ILE   A 1 311 ? 6.55041   -9.03213  34.65981  1.000 26.33248  ? 673 ILE   A H    1 
ATOM   4551 H HA   . ILE   A 1 311 ? 4.83746   -10.30802 33.16905  1.000 30.09282  ? 673 ILE   A HA   1 
ATOM   4552 H HB   . ILE   A 1 311 ? 7.09148   -11.01650 33.70226  1.000 34.05868  ? 673 ILE   A HB   1 
ATOM   4553 H HG12 . ILE   A 1 311 ? 5.52556   -13.31784 33.76651  1.000 40.79122  ? 673 ILE   A HG12 1 
ATOM   4554 H HG13 . ILE   A 1 311 ? 5.22543   -12.33005 32.55837  1.000 40.79122  ? 673 ILE   A HG13 1 
ATOM   4555 H HG21 . ILE   A 1 311 ? 7.46628   -12.39883 35.47342  1.000 41.58201  ? 673 ILE   A HG21 1 
ATOM   4556 H HG22 . ILE   A 1 311 ? 6.70197   -11.14438 36.07816  1.000 41.58201  ? 673 ILE   A HG22 1 
ATOM   4557 H HG23 . ILE   A 1 311 ? 5.91492   -12.49615 35.80104  1.000 41.58201  ? 673 ILE   A HG23 1 
ATOM   4558 H HD11 . ILE   A 1 311 ? 6.65582   -13.77821 31.69467  1.000 50.26143  ? 673 ILE   A HD11 1 
ATOM   4559 H HD12 . ILE   A 1 311 ? 7.57575   -12.53146 32.04516  1.000 50.26143  ? 673 ILE   A HD12 1 
ATOM   4560 H HD13 . ILE   A 1 311 ? 7.55332   -13.79685 33.00526  1.000 50.26143  ? 673 ILE   A HD13 1 
ATOM   4561 N N    . ASN   A 1 312 ? 4.04707   -10.21640 36.24751  1.000 26.17212  ? 674 ASN   A N    1 
ATOM   4562 C CA   . ASN   A 1 312 ? 2.89817   -10.43830 37.13355  1.000 25.82859  ? 674 ASN   A CA   1 
ATOM   4563 C C    . ASN   A 1 312 ? 1.61756   -9.74003  36.65760  1.000 29.99066  ? 674 ASN   A C    1 
ATOM   4564 O O    . ASN   A 1 312 ? 0.53209   -10.10394 37.12161  1.000 29.40122  ? 674 ASN   A O    1 
ATOM   4565 C CB   . ASN   A 1 312 ? 3.19123   -9.92972  38.54309  1.000 26.02183  ? 674 ASN   A CB   1 
ATOM   4566 C CG   . ASN   A 1 312 ? 4.19820   -10.79089 39.30166  1.000 34.76644  ? 674 ASN   A CG   1 
ATOM   4567 O OD1  . ASN   A 1 312 ? 4.80888   -11.69822 38.74339  1.000 35.58797  ? 674 ASN   A OD1  1 
ATOM   4568 N ND2  . ASN   A 1 312 ? 4.37950   -10.49129 40.58654  1.000 32.07523  ? 674 ASN   A ND2  1 
ATOM   4569 H H    . ASN   A 1 312 ? 4.69093   -9.76541  36.59630  1.000 31.41860  ? 674 ASN   A H    1 
ATOM   4570 H HA   . ASN   A 1 312 ? 2.75056   -11.39675 37.15568  1.000 31.00636  ? 674 ASN   A HA   1 
ATOM   4571 H HB2  . ASN   A 1 312 ? 3.55345   -9.03187  38.48349  1.000 31.23824  ? 674 ASN   A HB2  1 
ATOM   4572 H HB3  . ASN   A 1 312 ? 2.36513   -9.92112  39.05141  1.000 31.23824  ? 674 ASN   A HB3  1 
ATOM   4573 H HD21 . ASN   A 1 312 ? 4.93572   -10.94556 41.05966  1.000 38.50233  ? 674 ASN   A HD21 1 
ATOM   4574 H HD22 . ASN   A 1 312 ? 3.94034   -9.84354  40.94315  1.000 38.50233  ? 674 ASN   A HD22 1 
ATOM   4575 N N    . TYR   A 1 313 ? 1.72172   -8.71860  35.79016  1.000 27.66678  ? 675 TYR   A N    1 
ATOM   4576 C CA   . TYR   A 1 313 ? 0.59473   -7.89130  35.37436  1.000 27.88252  ? 675 TYR   A CA   1 
ATOM   4577 C C    . TYR   A 1 313 ? 0.12692   -8.17465  33.95120  1.000 26.71557  ? 675 TYR   A C    1 
ATOM   4578 O O    . TYR   A 1 313 ? -0.64830  -7.38549  33.38782  1.000 25.66987  ? 675 TYR   A O    1 
ATOM   4579 C CB   . TYR   A 1 313 ? 0.97512   -6.41285  35.52922  1.000 26.05215  ? 675 TYR   A CB   1 
ATOM   4580 C CG   . TYR   A 1 313 ? 1.18649   -6.08107  36.96938  1.000 26.19634  ? 675 TYR   A CG   1 
ATOM   4581 C CD1  . TYR   A 1 313 ? 0.10981   -5.83245  37.78490  1.000 25.38646  ? 675 TYR   A CD1  1 
ATOM   4582 C CD2  . TYR   A 1 313 ? 2.46806   -6.06044  37.53498  1.000 26.19589  ? 675 TYR   A CD2  1 
ATOM   4583 C CE1  . TYR   A 1 313 ? 0.28097   -5.56079  39.11784  1.000 28.36235  ? 675 TYR   A CE1  1 
ATOM   4584 C CE2  . TYR   A 1 313 ? 2.63992   -5.77662  38.87507  1.000 25.74475  ? 675 TYR   A CE2  1 
ATOM   4585 C CZ   . TYR   A 1 313 ? 1.54151   -5.55148  39.65963  1.000 26.88615  ? 675 TYR   A CZ   1 
ATOM   4586 O OH   . TYR   A 1 313 ? 1.70038   -5.26187  40.99752  1.000 29.26970  ? 675 TYR   A OH   1 
ATOM   4587 H H    . TYR   A 1 313 ? 2.46242   -8.48417  35.42137  1.000 33.21219  ? 675 TYR   A H    1 
ATOM   4588 H HA   . TYR   A 1 313 ? -0.16048  -8.08143  35.95264  1.000 33.47108  ? 675 TYR   A HA   1 
ATOM   4589 H HB2  . TYR   A 1 313 ? 1.79728   -6.23623  35.04574  1.000 31.27463  ? 675 TYR   A HB2  1 
ATOM   4590 H HB3  . TYR   A 1 313 ? 0.26062   -5.85529  35.18351  1.000 31.27463  ? 675 TYR   A HB3  1 
ATOM   4591 H HD1  . TYR   A 1 313 ? -0.74862  -5.84861  37.42750  1.000 30.47581  ? 675 TYR   A HD1  1 
ATOM   4592 H HD2  . TYR   A 1 313 ? 3.20957   -6.23953  37.00300  1.000 31.44712  ? 675 TYR   A HD2  1 
ATOM   4593 H HE1  . TYR   A 1 313 ? -0.45728  -5.38285  39.65470  1.000 34.04687  ? 675 TYR   A HE1  1 
ATOM   4594 H HE2  . TYR   A 1 313 ? 3.49401   -5.73878  39.24114  1.000 30.90575  ? 675 TYR   A HE2  1 
ATOM   4595 H HH   . TYR   A 1 313 ? 0.94998   -5.15305  41.35900  1.000 35.13569  ? 675 TYR   A HH   1 
ATOM   4596 N N    . ILE   A 1 314 ? 0.56457   -9.28515  33.36014  1.000 22.39039  ? 676 ILE   A N    1 
ATOM   4597 C CA   . ILE   A 1 314 ? 0.12849   -9.61778  32.00088  1.000 26.83845  ? 676 ILE   A CA   1 
ATOM   4598 C C    . ILE   A 1 314 ? -1.37959  -9.82630  31.92511  1.000 29.35005  ? 676 ILE   A C    1 
ATOM   4599 O O    . ILE   A 1 314 ? -2.00134  -9.32295  30.97107  1.000 32.49621  ? 676 ILE   A O    1 
ATOM   4600 C CB   . ILE   A 1 314 ? 0.92886   -10.80259 31.45925  1.000 28.43641  ? 676 ILE   A CB   1 
ATOM   4601 C CG1  . ILE   A 1 314 ? 2.43385   -10.44922 31.36479  1.000 29.77053  ? 676 ILE   A CG1  1 
ATOM   4602 C CG2  . ILE   A 1 314 ? 0.40669   -11.21889 30.08492  1.000 28.16673  ? 676 ILE   A CG2  1 
ATOM   4603 C CD1  . ILE   A 1 314 ? 2.76658   -9.31066  30.42241  1.000 26.81832  ? 676 ILE   A CD1  1 
ATOM   4604 H H    . ILE   A 1 314 ? 1.10382   -9.85363  33.71459  1.000 26.88052  ? 676 ILE   A H    1 
ATOM   4605 H HA   . ILE   A 1 314 ? 0.34400   -8.85723  31.43871  1.000 32.21819  ? 676 ILE   A HA   1 
ATOM   4606 H HB   . ILE   A 1 314 ? 0.81980   -11.54248 32.07696  1.000 34.13574  ? 676 ILE   A HB   1 
ATOM   4607 H HG12 . ILE   A 1 314 ? 2.74584   -10.19634 32.24775  1.000 35.73669  ? 676 ILE   A HG12 1 
ATOM   4608 H HG13 . ILE   A 1 314 ? 2.91434   -11.23283 31.05497  1.000 35.73669  ? 676 ILE   A HG13 1 
ATOM   4609 H HG21 . ILE   A 1 314 ? 1.11072   -11.68509 29.60754  1.000 33.81212  ? 676 ILE   A HG21 1 
ATOM   4610 H HG22 . ILE   A 1 314 ? -0.35771  -11.80452 30.20164  1.000 33.81212  ? 676 ILE   A HG22 1 
ATOM   4611 H HG23 . ILE   A 1 314 ? 0.14329   -10.42517 29.59346  1.000 33.81212  ? 676 ILE   A HG23 1 
ATOM   4612 H HD11 . ILE   A 1 314 ? 3.72859   -9.26826  30.30563  1.000 32.19403  ? 676 ILE   A HD11 1 
ATOM   4613 H HD12 . ILE   A 1 314 ? 2.33644   -9.47189  29.56807  1.000 32.19403  ? 676 ILE   A HD12 1 
ATOM   4614 H HD13 . ILE   A 1 314 ? 2.44278   -8.47983  30.80420  1.000 32.19403  ? 676 ILE   A HD13 1 
ATOM   4615 N N    . PRO   A 1 315 ? -2.03251  -10.56210 32.84817  1.000 26.95432  ? 677 PRO   A N    1 
ATOM   4616 C CA   . PRO   A 1 315 ? -3.49934  -10.63708 32.77742  1.000 22.92577  ? 677 PRO   A CA   1 
ATOM   4617 C C    . PRO   A 1 315 ? -4.15648  -9.25575  32.82304  1.000 24.58197  ? 677 PRO   A C    1 
ATOM   4618 O O    . PRO   A 1 315 ? -5.09219  -8.99084  32.06549  1.000 27.31881  ? 677 PRO   A O    1 
ATOM   4619 C CB   . PRO   A 1 315 ? -3.87191  -11.49200 33.99571  1.000 27.04460  ? 677 PRO   A CB   1 
ATOM   4620 C CG   . PRO   A 1 315 ? -2.63790  -12.30142 34.31017  1.000 31.80031  ? 677 PRO   A CG   1 
ATOM   4621 C CD   . PRO   A 1 315 ? -1.49876  -11.37010 33.96552  1.000 29.18020  ? 677 PRO   A CD   1 
ATOM   4622 H HA   . PRO   A 1 315 ? -3.77300  -11.10534 31.97322  1.000 27.52297  ? 677 PRO   A HA   1 
ATOM   4623 H HB2  . PRO   A 1 315 ? -4.10732  -10.91717 34.74073  1.000 32.46557  ? 677 PRO   A HB2  1 
ATOM   4624 H HB3  . PRO   A 1 315 ? -4.61807  -12.07108 33.77479  1.000 32.46557  ? 677 PRO   A HB3  1 
ATOM   4625 H HG2  . PRO   A 1 315 ? -2.62391  -12.54034 35.25018  1.000 38.17243  ? 677 PRO   A HG2  1 
ATOM   4626 H HG3  . PRO   A 1 315 ? -2.61394  -13.10258 33.76384  1.000 38.17243  ? 677 PRO   A HG3  1 
ATOM   4627 H HD2  . PRO   A 1 315 ? -1.27564  -10.80543 34.72201  1.000 35.02830  ? 677 PRO   A HD2  1 
ATOM   4628 H HD3  . PRO   A 1 315 ? -0.71771  -11.87188 33.68430  1.000 35.02830  ? 677 PRO   A HD3  1 
ATOM   4629 N N    . TRP   A 1 316 ? -3.67950  -8.37747  33.70593  1.000 24.85888  ? 678 TRP   A N    1 
ATOM   4630 C CA   . TRP   A 1 316 ? -4.25397  -7.03666  33.82744  1.000 30.60935  ? 678 TRP   A CA   1 
ATOM   4631 C C    . TRP   A 1 316 ? -4.07633  -6.25834  32.53316  1.000 27.37982  ? 678 TRP   A C    1 
ATOM   4632 O O    . TRP   A 1 316 ? -5.02168  -5.67136  32.00475  1.000 29.88163  ? 678 TRP   A O    1 
ATOM   4633 C CB   . TRP   A 1 316 ? -3.56679  -6.30548  34.98530  1.000 32.84059  ? 678 TRP   A CB   1 
ATOM   4634 C CG   . TRP   A 1 316 ? -4.12791  -4.96861  35.30798  1.000 29.59767  ? 678 TRP   A CG   1 
ATOM   4635 C CD1  . TRP   A 1 316 ? -5.22197  -4.70095  36.07784  1.000 29.65795  ? 678 TRP   A CD1  1 
ATOM   4636 C CD2  . TRP   A 1 316 ? -3.61547  -3.71048  34.89099  1.000 26.16088  ? 678 TRP   A CD2  1 
ATOM   4637 N NE1  . TRP   A 1 316 ? -5.40686  -3.35084  36.17715  1.000 31.12668  ? 678 TRP   A NE1  1 
ATOM   4638 C CE2  . TRP   A 1 316 ? -4.43797  -2.71554  35.45215  1.000 26.28207  ? 678 TRP   A CE2  1 
ATOM   4639 C CE3  . TRP   A 1 316 ? -2.52996  -3.32362  34.11257  1.000 29.80350  ? 678 TRP   A CE3  1 
ATOM   4640 C CZ2  . TRP   A 1 316 ? -4.22106  -1.35324  35.23428  1.000 29.10334  ? 678 TRP   A CZ2  1 
ATOM   4641 C CZ3  . TRP   A 1 316 ? -2.31526  -1.96426  33.90233  1.000 29.76622  ? 678 TRP   A CZ3  1 
ATOM   4642 C CH2  . TRP   A 1 316 ? -3.15046  -1.00674  34.46353  1.000 23.91177  ? 678 TRP   A CH2  1 
ATOM   4643 H H    . TRP   A 1 316 ? -3.02684  -8.53115  34.24445  1.000 29.84270  ? 678 TRP   A H    1 
ATOM   4644 H HA   . TRP   A 1 316 ? -5.20334  -7.10303  34.01499  1.000 36.74327  ? 678 TRP   A HA   1 
ATOM   4645 H HB2  . TRP   A 1 316 ? -3.64389  -6.85270  35.78248  1.000 39.42076  ? 678 TRP   A HB2  1 
ATOM   4646 H HB3  . TRP   A 1 316 ? -2.63217  -6.18069  34.75767  1.000 39.42076  ? 678 TRP   A HB3  1 
ATOM   4647 H HD1  . TRP   A 1 316 ? -5.76295  -5.34366  36.47680  1.000 35.60159  ? 678 TRP   A HD1  1 
ATOM   4648 H HE1  . TRP   A 1 316 ? -6.03165  -2.96355  36.62351  1.000 37.36407  ? 678 TRP   A HE1  1 
ATOM   4649 H HE3  . TRP   A 1 316 ? -1.96065  -3.95826  33.74107  1.000 35.77626  ? 678 TRP   A HE3  1 
ATOM   4650 H HZ2  . TRP   A 1 316 ? -4.78340  -0.70890  35.59966  1.000 34.93606  ? 678 TRP   A HZ2  1 
ATOM   4651 H HZ3  . TRP   A 1 316 ? -1.59863  -1.69195  33.37584  1.000 35.73152  ? 678 TRP   A HZ3  1 
ATOM   4652 H HH2  . TRP   A 1 316 ? -2.97520  -0.10643  34.30982  1.000 28.70618  ? 678 TRP   A HH2  1 
ATOM   4653 N N    . ILE   A 1 317 ? -2.86135  -6.27804  31.99629  1.000 29.44550  ? 679 ILE   A N    1 
ATOM   4654 C CA   . ILE   A 1 317 ? -2.54965  -5.53507  30.78366  1.000 25.87688  ? 679 ILE   A CA   1 
ATOM   4655 C C    . ILE   A 1 317 ? -3.42683  -6.02524  29.65824  1.000 28.19527  ? 679 ILE   A C    1 
ATOM   4656 O O    . ILE   A 1 317 ? -4.07803  -5.24238  28.94587  1.000 25.90430  ? 679 ILE   A O    1 
ATOM   4657 C CB   . ILE   A 1 317 ? -1.05679  -5.69119  30.43607  1.000 23.02125  ? 679 ILE   A CB   1 
ATOM   4658 C CG1  . ILE   A 1 317 ? -0.18203  -4.94913  31.45305  1.000 23.81512  ? 679 ILE   A CG1  1 
ATOM   4659 C CG2  . ILE   A 1 317 ? -0.78049  -5.17755  29.03629  1.000 27.78659  ? 679 ILE   A CG2  1 
ATOM   4660 C CD1  . ILE   A 1 317 ? 1.24481   -5.42840  31.47856  1.000 25.32229  ? 679 ILE   A CD1  1 
ATOM   4661 H H    . ILE   A 1 317 ? -2.19497  -6.71697  32.31705  1.000 35.34666  ? 679 ILE   A H    1 
ATOM   4662 H HA   . ILE   A 1 317 ? -2.72773  -4.59279  30.92962  1.000 31.06430  ? 679 ILE   A HA   1 
ATOM   4663 H HB   . ILE   A 1 317 ? -0.83858  -6.63562  30.47259  1.000 27.63755  ? 679 ILE   A HB   1 
ATOM   4664 H HG12 . ILE   A 1 317 ? -0.17470  -4.00518  31.22988  1.000 28.59019  ? 679 ILE   A HG12 1 
ATOM   4665 H HG13 . ILE   A 1 317 ? -0.55476  -5.07762  32.33931  1.000 28.59019  ? 679 ILE   A HG13 1 
ATOM   4666 H HG21 . ILE   A 1 317 ? 0.16369   -4.96999  28.95670  1.000 33.35596  ? 679 ILE   A HG21 1 
ATOM   4667 H HG22 . ILE   A 1 317 ? -1.02369  -5.86311  28.39460  1.000 33.35596  ? 679 ILE   A HG22 1 
ATOM   4668 H HG23 . ILE   A 1 317 ? -1.30885  -4.37865  28.88303  1.000 33.35596  ? 679 ILE   A HG23 1 
ATOM   4669 H HD11 . ILE   A 1 317 ? 1.69626   -5.03568  32.24201  1.000 30.39880  ? 679 ILE   A HD11 1 
ATOM   4670 H HD12 . ILE   A 1 317 ? 1.25181   -6.39561  31.55168  1.000 30.39880  ? 679 ILE   A HD12 1 
ATOM   4671 H HD13 . ILE   A 1 317 ? 1.68432   -5.15552  30.65803  1.000 30.39880  ? 679 ILE   A HD13 1 
ATOM   4672 N N    . GLU   A 1 318 ? -3.46177  -7.34444  29.50086  1.000 32.02529  ? 680 GLU   A N    1 
ATOM   4673 C CA   . GLU   A 1 318 ? -4.24689  -7.95759  28.44721  1.000 32.57857  ? 680 GLU   A CA   1 
ATOM   4674 C C    . GLU   A 1 318 ? -5.72946  -7.71043  28.65240  1.000 30.50378  ? 680 GLU   A C    1 
ATOM   4675 O O    . GLU   A 1 318 ? -6.45425  -7.48437  27.68005  1.000 26.36404  ? 680 GLU   A O    1 
ATOM   4676 C CB   . GLU   A 1 318 ? -3.93819  -9.45651  28.38709  1.000 37.32231  ? 680 GLU   A CB   1 
ATOM   4677 C CG   . GLU   A 1 318 ? -2.55111  -9.75132  27.81543  1.000 48.06709  ? 680 GLU   A CG   1 
ATOM   4678 C CD   . GLU   A 1 318 ? -2.24675  -11.23873 27.69402  1.000 54.12747  ? 680 GLU   A CD   1 
ATOM   4679 O OE1  . GLU   A 1 318 ? -2.76873  -12.03551 28.50554  1.000 58.99727  ? 680 GLU   A OE1  1 
ATOM   4680 O OE2  . GLU   A 1 318 ? -1.49762  -11.59980 26.76511  1.000 53.97873  ? 680 GLU   A OE2  1 
ATOM   4681 H H    . GLU   A 1 318 ? -3.03717  -7.90645  29.99427  1.000 38.44240  ? 680 GLU   A H    1 
ATOM   4682 H HA   . GLU   A 1 318 ? -4.00310  -7.56653  27.59367  1.000 39.10633  ? 680 GLU   A HA   1 
ATOM   4683 H HB2  . GLU   A 1 318 ? -3.97770  -9.82331  29.28420  1.000 44.79883  ? 680 GLU   A HB2  1 
ATOM   4684 H HB3  . GLU   A 1 318 ? -4.59509  -9.89179  27.82147  1.000 44.79883  ? 680 GLU   A HB3  1 
ATOM   4685 H HG2  . GLU   A 1 318 ? -2.48870  -9.36248  26.92897  1.000 57.69256  ? 680 GLU   A HG2  1 
ATOM   4686 H HG3  . GLU   A 1 318 ? -1.88242  -9.35832  28.39792  1.000 57.69256  ? 680 GLU   A HG3  1 
ATOM   4687 N N    . ASN   A 1 319 ? -6.19596  -7.73642  29.90182  1.000 30.72221  ? 681 ASN   A N    1 
ATOM   4688 C CA   . ASN   A 1 319 ? -7.59565  -7.41765  30.18552  1.000 28.95520  ? 681 ASN   A CA   1 
ATOM   4689 C C    . ASN   A 1 319 ? -7.93524  -6.01570  29.68674  1.000 34.67185  ? 681 ASN   A C    1 
ATOM   4690 O O    . ASN   A 1 319 ? -8.97125  -5.80720  29.04633  1.000 29.92996  ? 681 ASN   A O    1 
ATOM   4691 C CB   . ASN   A 1 319 ? -7.86877  -7.55683  31.69378  1.000 32.88142  ? 681 ASN   A CB   1 
ATOM   4692 C CG   . ASN   A 1 319 ? -9.26081  -7.00120  32.14072  1.000 42.72222  ? 681 ASN   A CG   1 
ATOM   4693 O OD1  . ASN   A 1 319 ? -9.58881  -5.83170  31.94352  1.000 42.50320  ? 681 ASN   A OD1  1 
ATOM   4694 N ND2  . ASN   A 1 319 ? -10.05318 -7.85220  32.77499  1.000 44.02489  ? 681 ASN   A ND2  1 
ATOM   4695 H H    . ASN   A 1 319 ? -5.72835  -7.93326  30.59622  1.000 36.87871  ? 681 ASN   A H    1 
ATOM   4696 H HA   . ASN   A 1 319 ? -8.17195  -8.04763  29.72519  1.000 34.75829  ? 681 ASN   A HA   1 
ATOM   4697 H HB2  . ASN   A 1 319 ? -7.83660  -8.49689  31.93075  1.000 39.46975  ? 681 ASN   A HB2  1 
ATOM   4698 H HB3  . ASN   A 1 319 ? -7.18633  -7.06851  32.18031  1.000 39.46975  ? 681 ASN   A HB3  1 
ATOM   4699 H HD21 . ASN   A 1 319 ? -10.83006 -7.59853  33.04278  1.000 52.84192  ? 681 ASN   A HD21 1 
ATOM   4700 H HD22 . ASN   A 1 319 ? -9.79079  -8.65843  32.91903  1.000 52.84192  ? 681 ASN   A HD22 1 
ATOM   4701 N N    . ILE   A 1 320 ? -7.06578  -5.03893  29.96259  1.000 31.23733  ? 682 ILE   A N    1 
ATOM   4702 C CA   . ILE   A 1 320 ? -7.39055  -3.66681  29.59387  1.000 29.25397  ? 682 ILE   A CA   1 
ATOM   4703 C C    . ILE   A 1 320 ? -7.27821  -3.47034  28.08401  1.000 26.52637  ? 682 ILE   A C    1 
ATOM   4704 O O    . ILE   A 1 320 ? -8.16665  -2.89003  27.44875  1.000 29.01023  ? 682 ILE   A O    1 
ATOM   4705 C CB   . ILE   A 1 320 ? -6.51077  -2.68078  30.37438  1.000 28.79433  ? 682 ILE   A CB   1 
ATOM   4706 C CG1  . ILE   A 1 320 ? -7.10287  -2.55210  31.77413  1.000 30.31644  ? 682 ILE   A CG1  1 
ATOM   4707 C CG2  . ILE   A 1 320 ? -6.46876  -1.28968  29.67700  1.000 33.08025  ? 682 ILE   A CG2  1 
ATOM   4708 C CD1  . ILE   A 1 320 ? -6.20644  -2.01776  32.74650  1.000 30.32840  ? 682 ILE   A CD1  1 
ATOM   4709 H H    . ILE   A 1 320 ? -6.30559  -5.14467  30.35058  1.000 37.49685  ? 682 ILE   A H    1 
ATOM   4710 H HA   . ILE   A 1 320 ? -8.31337  -3.49326  29.83718  1.000 35.11682  ? 682 ILE   A HA   1 
ATOM   4711 H HB   . ILE   A 1 320 ? -5.59949  -3.01107  30.41164  1.000 34.56525  ? 682 ILE   A HB   1 
ATOM   4712 H HG12 . ILE   A 1 320 ? -7.87335  -1.96438  31.73127  1.000 36.39178  ? 682 ILE   A HG12 1 
ATOM   4713 H HG13 . ILE   A 1 320 ? -7.37378  -3.43268  32.07758  1.000 36.39178  ? 682 ILE   A HG13 1 
ATOM   4714 H HG21 . ILE   A 1 320 ? -6.13405  -0.63121  30.30571  1.000 39.70835  ? 682 ILE   A HG21 1 
ATOM   4715 H HG22 . ILE   A 1 320 ? -5.88130  -1.34015  28.90678  1.000 39.70835  ? 682 ILE   A HG22 1 
ATOM   4716 H HG23 . ILE   A 1 320 ? -7.36537  -1.05105  29.39407  1.000 39.70835  ? 682 ILE   A HG23 1 
ATOM   4717 H HD11 . ILE   A 1 320 ? -6.63593  -2.03655  33.61603  1.000 36.40614  ? 682 ILE   A HD11 1 
ATOM   4718 H HD12 . ILE   A 1 320 ? -5.40081  -2.55772  32.76377  1.000 36.40614  ? 682 ILE   A HD12 1 
ATOM   4719 H HD13 . ILE   A 1 320 ? -5.98718  -1.10410  32.50555  1.000 36.40614  ? 682 ILE   A HD13 1 
ATOM   4720 N N    . ILE   A 1 321 ? -6.18724  -3.93143  27.49050  1.000 22.44410  ? 683 ILE   A N    1 
ATOM   4721 C CA   . ILE   A 1 321 ? -6.00553  -3.72176  26.06625  1.000 26.41850  ? 683 ILE   A CA   1 
ATOM   4722 C C    . ILE   A 1 321 ? -7.06540  -4.47363  25.27242  1.000 30.22414  ? 683 ILE   A C    1 
ATOM   4723 O O    . ILE   A 1 321 ? -7.52918  -3.99253  24.23701  1.000 31.65684  ? 683 ILE   A O    1 
ATOM   4724 C CB   . ILE   A 1 321 ? -4.59392  -4.13343  25.62867  1.000 27.23369  ? 683 ILE   A CB   1 
ATOM   4725 C CG1  . ILE   A 1 321 ? -3.58074  -3.18806  26.28458  1.000 26.49656  ? 683 ILE   A CG1  1 
ATOM   4726 C CG2  . ILE   A 1 321 ? -4.50717  -4.12302  24.06822  1.000 28.81053  ? 683 ILE   A CG2  1 
ATOM   4727 C CD1  . ILE   A 1 321 ? -2.09659  -3.53345  25.98297  1.000 30.27665  ? 683 ILE   A CD1  1 
ATOM   4728 H H    . ILE   A 1 321 ? -5.55183  -4.35920  27.88148  1.000 26.94498  ? 683 ILE   A H    1 
ATOM   4729 H HA   . ILE   A 1 321 ? -6.10886  -2.77314  25.89204  1.000 31.71426  ? 683 ILE   A HA   1 
ATOM   4730 H HB   . ILE   A 1 321 ? -4.38983  -5.03596  25.91968  1.000 32.69248  ? 683 ILE   A HB   1 
ATOM   4731 H HG12 . ILE   A 1 321 ? -3.74402  -2.28756  25.96312  1.000 31.80792  ? 683 ILE   A HG12 1 
ATOM   4732 H HG13 . ILE   A 1 321 ? -3.70113  -3.22389  27.24642  1.000 31.80792  ? 683 ILE   A HG13 1 
ATOM   4733 H HG21 . ILE   A 1 321 ? -3.57495  -4.07754  23.80405  1.000 34.58469  ? 683 ILE   A HG21 1 
ATOM   4734 H HG22 . ILE   A 1 321 ? -4.90920  -4.93597  23.72415  1.000 34.58469  ? 683 ILE   A HG22 1 
ATOM   4735 H HG23 . ILE   A 1 321 ? -4.98479  -3.34923  23.73053  1.000 34.58469  ? 683 ILE   A HG23 1 
ATOM   4736 H HD11 . ILE   A 1 321 ? -1.52930  -3.07366  26.62146  1.000 36.34404  ? 683 ILE   A HD11 1 
ATOM   4737 H HD12 . ILE   A 1 321 ? -1.97327  -4.49238  26.06143  1.000 36.34404  ? 683 ILE   A HD12 1 
ATOM   4738 H HD13 . ILE   A 1 321 ? -1.88201  -3.24498  25.08206  1.000 36.34404  ? 683 ILE   A HD13 1 
ATOM   4739 N N    . SER   A 1 322 ? -7.45579  -5.67042  25.72837  1.000 29.48893  ? 684 SER   A N    1 
ATOM   4740 C CA   . SER   A 1 322 ? -8.41788  -6.43911  24.94555  1.000 31.57716  ? 684 SER   A CA   1 
ATOM   4741 C C    . SER   A 1 322 ? -9.81670  -5.84275  25.03095  1.000 31.71295  ? 684 SER   A C    1 
ATOM   4742 O O    . SER   A 1 322 ? -10.60462 -5.98874  24.08697  1.000 35.54348  ? 684 SER   A O    1 
ATOM   4743 C CB   . SER   A 1 322 ? -8.43154  -7.90271  25.39165  1.000 30.82233  ? 684 SER   A CB   1 
ATOM   4744 O OG   . SER   A 1 322 ? -9.08392  -8.05890  26.63757  1.000 35.30257  ? 684 SER   A OG   1 
ATOM   4745 H H    . SER   A 1 322 ? -7.18805  -6.04069  26.45694  1.000 35.39877  ? 684 SER   A H    1 
ATOM   4746 H HA   . SER   A 1 322 ? -8.13961  -6.42087  24.01650  1.000 37.90465  ? 684 SER   A HA   1 
ATOM   4747 H HB2  . SER   A 1 322 ? -8.89982  -8.42898  24.72483  1.000 36.99885  ? 684 SER   A HB2  1 
ATOM   4748 H HB3  . SER   A 1 322 ? -7.51636  -8.21284  25.47632  1.000 36.99885  ? 684 SER   A HB3  1 
ATOM   4749 H HG   . SER   A 1 322 ? -8.67800  -7.62436  27.23088  1.000 42.37514  ? 684 SER   A HG   1 
ATOM   4750 N N    . ASP   A 1 323 ? -10.13127 -5.14485  26.12763  1.000 29.33979  ? 685 ASP   A N    1 
ATOM   4751 C CA   . ASP   A 1 323 ? -11.47294 -4.62367  26.36493  1.000 31.01885  ? 685 ASP   A CA   1 
ATOM   4752 C C    . ASP   A 1 323 ? -11.66755 -3.19298  25.88712  1.000 29.45691  ? 685 ASP   A C    1 
ATOM   4753 O O    . ASP   A 1 323 ? -12.80791 -2.79316  25.66078  1.000 33.56009  ? 685 ASP   A O    1 
ATOM   4754 C CB   . ASP   A 1 323 ? -11.80846 -4.69214  27.86184  1.000 31.25388  ? 685 ASP   A CB   1 
ATOM   4755 C CG   . ASP   A 1 323 ? -13.27108 -4.96732  28.13529  1.000 30.45120  ? 685 ASP   A CG   1 
ATOM   4756 O OD1  . ASP   A 1 323 ? -13.99435 -5.52041  27.26432  1.000 32.07928  ? 685 ASP   A OD1  1 
ATOM   4757 O OD2  . ASP   A 1 323 ? -13.72682 -4.59554  29.24574  1.000 30.31532  ? 685 ASP   A OD2  1 
ATOM   4758 H H    . ASP   A 1 323 ? -9.57428  -4.95922  26.75604  1.000 35.21980  ? 685 ASP   A H    1 
ATOM   4759 H HA   . ASP   A 1 323 ? -12.10122 -5.18271  25.88156  1.000 37.23468  ? 685 ASP   A HA   1 
ATOM   4760 H HB2  . ASP   A 1 323 ? -11.29056 -5.40499  28.26745  1.000 37.51671  ? 685 ASP   A HB2  1 
ATOM   4761 H HB3  . ASP   A 1 323 ? -11.58334 -3.84305  28.27327  1.000 37.51671  ? 685 ASP   A HB3  1 
ATOM   4762 N N    . PHE   A 1 324 ? -10.59785 -2.41513  25.75589  1.000 34.45173  ? 686 PHE   A N    1 
ATOM   4763 C CA   . PHE   A 1 324 ? -10.67239 -1.05716  25.23634  1.000 33.26048  ? 686 PHE   A CA   1 
ATOM   4764 C C    . PHE   A 1 324 ? -9.75772  -0.96802  24.02217  1.000 39.46164  ? 686 PHE   A C    1 
ATOM   4765 O O    . PHE   A 1 324 ? -9.21305  -1.97711  23.58193  1.000 50.66840  ? 686 PHE   A O    1 
ATOM   4766 C CB   . PHE   A 1 324 ? -10.28076 -0.03603  26.29724  1.000 34.80715  ? 686 PHE   A CB   1 
ATOM   4767 C CG   . PHE   A 1 324 ? -11.20464 -0.00834  27.48489  1.000 37.08632  ? 686 PHE   A CG   1 
ATOM   4768 C CD1  . PHE   A 1 324 ? -11.00685 -0.87827  28.54497  1.000 35.69249  ? 686 PHE   A CD1  1 
ATOM   4769 C CD2  . PHE   A 1 324 ? -12.27172 0.87789   27.54588  1.000 33.76624  ? 686 PHE   A CD2  1 
ATOM   4770 C CE1  . PHE   A 1 324 ? -11.85324 -0.87473  29.63965  1.000 38.29212  ? 686 PHE   A CE1  1 
ATOM   4771 C CE2  . PHE   A 1 324 ? -13.12267 0.87481   28.66079  1.000 35.28577  ? 686 PHE   A CE2  1 
ATOM   4772 C CZ   . PHE   A 1 324 ? -12.90060 -0.00088  29.69304  1.000 35.71116  ? 686 PHE   A CZ   1 
ATOM   4773 O OXT  . PHE   A 1 324 ? -9.54281  0.08323   23.43522  1.000 45.93918  ? 686 PHE   A OXT  1 
ATOM   4774 H H    . PHE   A 1 324 ? -9.79981  -2.65725  25.96588  1.000 41.35413  ? 686 PHE   A H    1 
ATOM   4775 H HA   . PHE   A 1 324 ? -11.58073 -0.83424  24.97917  1.000 39.92463  ? 686 PHE   A HA   1 
ATOM   4776 H HB2  . PHE   A 1 324 ? -9.39073  -0.24753  26.61978  1.000 41.78063  ? 686 PHE   A HB2  1 
ATOM   4777 H HB3  . PHE   A 1 324 ? -10.28727 0.84744   25.89682  1.000 41.78063  ? 686 PHE   A HB3  1 
ATOM   4778 H HD1  . PHE   A 1 324 ? -10.29347 -1.47441  28.52038  1.000 42.84305  ? 686 PHE   A HD1  1 
ATOM   4779 H HD2  . PHE   A 1 324 ? -12.42219 1.47342   26.84760  1.000 40.53154  ? 686 PHE   A HD2  1 
ATOM   4780 H HE1  . PHE   A 1 324 ? -11.70828 -1.46881  30.34033  1.000 45.96260  ? 686 PHE   A HE1  1 
ATOM   4781 H HE2  . PHE   A 1 324 ? -13.83845 1.46727   28.70028  1.000 42.35498  ? 686 PHE   A HE2  1 
ATOM   4782 H HZ   . PHE   A 1 324 ? -13.46553 0.00078   30.43178  1.000 42.86544  ? 686 PHE   A HZ   1 
HETATM 4783 C C13  . A1A1X B 2 .   ? 13.80841  5.51421   39.86225  1.000 40.54573  ? 701 A1A1X A C13  1 
HETATM 4784 C C15  . A1A1X B 2 .   ? 11.92615  8.66211   48.96909  1.000 74.38861  ? 701 A1A1X A C15  1 
HETATM 4785 C C11  . A1A1X B 2 .   ? 14.27612  6.19027   42.08331  1.000 43.89380  ? 701 A1A1X A C11  1 
HETATM 4786 C C12  . A1A1X B 2 .   ? 14.53773  5.39258   41.01302  1.000 46.98430  ? 701 A1A1X A C12  1 
HETATM 4787 C C14  . A1A1X B 2 .   ? 12.79842  6.41062   39.73644  1.000 42.56052  ? 701 A1A1X A C14  1 
HETATM 4788 C C16  . A1A1X B 2 .   ? 11.39973  8.33063   50.21603  1.000 69.93540  ? 701 A1A1X A C16  1 
HETATM 4789 C C1   . A1A1X B 2 .   ? 8.86484   6.50686   51.96054  1.000 51.25406  ? 701 A1A1X A C1   1 
HETATM 4790 C C10  . A1A1X B 2 .   ? 13.25591  7.08556   41.94685  1.000 36.59899  ? 701 A1A1X A C10  1 
HETATM 4791 C C2   . A1A1X B 2 .   ? 10.30109  6.73794   51.78965  1.000 61.11682  ? 701 A1A1X A C2   1 
HETATM 4792 C C3   . A1A1X B 2 .   ? 10.83540  7.09255   50.43927  1.000 69.49061  ? 701 A1A1X A C3   1 
HETATM 4793 C C4   . A1A1X B 2 .   ? 10.85045  6.20444   49.31637  1.000 65.81107  ? 701 A1A1X A C4   1 
HETATM 4794 C C5   . A1A1X B 2 .   ? 11.88217  7.74232   47.88775  1.000 66.64230  ? 701 A1A1X A C5   1 
HETATM 4795 C C6   . A1A1X B 2 .   ? 12.31333  7.61915   45.36439  1.000 51.47781  ? 701 A1A1X A C6   1 
HETATM 4796 C C7   . A1A1X B 2 .   ? 13.21231  8.25251   44.23042  1.000 51.52605  ? 701 A1A1X A C7   1 
HETATM 4797 C C8   . A1A1X B 2 .   ? 11.67109  8.67544   42.13383  1.000 56.23917  ? 701 A1A1X A C8   1 
HETATM 4798 C C9   . A1A1X B 2 .   ? 12.50901  7.20227   40.78822  1.000 41.65630  ? 701 A1A1X A C9   1 
HETATM 4799 N N1   . A1A1X B 2 .   ? 11.36104  6.47690   48.07522  1.000 57.25819  ? 701 A1A1X A N1   1 
HETATM 4800 N N2   . A1A1X B 2 .   ? 12.47824  8.11694   46.64474  1.000 61.00930  ? 701 A1A1X A N2   1 
HETATM 4801 N N3   . A1A1X B 2 .   ? 12.74473  8.01228   42.85661  1.000 54.65906  ? 701 A1A1X A N3   1 
HETATM 4802 N N4   . A1A1X B 2 .   ? 11.50502  8.20560   40.87216  1.000 52.18819  ? 701 A1A1X A N4   1 
HETATM 4803 N N5   . A1A1X B 2 .   ? 10.92277  9.68984   42.73021  1.000 67.33727  ? 701 A1A1X A N5   1 
HETATM 4804 O O1   . A1A1X B 2 .   ? 11.48985  6.73618   45.14374  1.000 50.03256  ? 701 A1A1X A O1   1 
HETATM 4805 H HC13 . A1A1X B 2 .   ? 14.06060  4.85925   39.02434  1.000 48.66692  ? 701 A1A1X A HC13 1 
HETATM 4806 H HC15 . A1A1X B 2 .   ? 12.37315  9.65139   48.85089  1.000 89.27839  ? 701 A1A1X A HC15 1 
HETATM 4807 H HC11 . A1A1X B 2 .   ? 14.84562  6.12671   43.00817  1.000 52.68462  ? 701 A1A1X A HC11 1 
HETATM 4808 H HC12 . A1A1X B 2 .   ? 15.33615  4.65191   41.07797  1.000 56.39322  ? 701 A1A1X A HC12 1 
HETATM 4809 H HC14 . A1A1X B 2 .   ? 12.24337  6.47663   38.79950  1.000 51.08468  ? 701 A1A1X A HC14 1 
HETATM 4810 H HC16 . A1A1X B 2 .   ? 11.43496  9.06340   51.02894  1.000 83.93453  ? 701 A1A1X A HC16 1 
HETATM 4811 H H1_3 . A1A1X B 2 .   ? 8.61209   6.31514   53.01902  1.000 61.51693  ? 701 A1A1X A H1_3 1 
HETATM 4812 H H1_2 . A1A1X B 2 .   ? 8.52580   5.63438   51.37330  1.000 61.51693  ? 701 A1A1X A H1_2 1 
HETATM 4813 H H1_1 . A1A1X B 2 .   ? 8.27531   7.38101   51.62986  1.000 61.51693  ? 701 A1A1X A H1_1 1 
HETATM 4814 H H2_1 . A1A1X B 2 .   ? 10.81558  5.83222   52.18174  1.000 73.35224  ? 701 A1A1X A H2_1 1 
HETATM 4815 H H2_2 . A1A1X B 2 .   ? 10.58658  7.51543   52.53314  1.000 73.35224  ? 701 A1A1X A H2_2 1 
HETATM 4816 H HC4  . A1A1X B 2 .   ? 10.42431  5.19894   49.40905  1.000 78.98534  ? 701 A1A1X A HC4  1 
HETATM 4817 H H7_2 . A1A1X B 2 .   ? 13.30822  9.35654   44.37044  1.000 61.84332  ? 701 A1A1X A H7_2 1 
HETATM 4818 H H7_1 . A1A1X B 2 .   ? 14.26320  7.88104   44.30342  1.000 61.84332  ? 701 A1A1X A H7_1 1 
HETATM 4819 H HN2  . A1A1X B 2 .   ? 13.13337  8.88696   46.75501  1.000 73.22321  ? 701 A1A1X A HN2  1 
HETATM 4820 H H5_1 . A1A1X B 2 .   ? 10.13465  9.46015   43.28951  1.000 80.81678  ? 701 A1A1X A H5_1 1 
HETATM 4821 H H5_2 . A1A1X B 2 .   ? 11.17195  10.64861  42.60280  1.000 80.81678  ? 701 A1A1X A H5_2 1 
HETATM 4822 C C1   . GOL   C 3 .   ? 17.31367  -20.59508 35.56356  1.000 44.29714  ? 702 GOL   A C1   1 
HETATM 4823 O O1   . GOL   C 3 .   ? 17.65939  -21.84301 36.00474  1.000 36.73191  ? 702 GOL   A O1   1 
HETATM 4824 C C2   . GOL   C 3 .   ? 16.73165  -20.83931 34.16512  1.000 41.25503  ? 702 GOL   A C2   1 
HETATM 4825 O O2   . GOL   C 3 .   ? 15.63307  -20.09308 33.81154  1.000 34.75907  ? 702 GOL   A O2   1 
HETATM 4826 C C3   . GOL   C 3 .   ? 17.81479  -20.56552 33.20328  1.000 36.76885  ? 702 GOL   A C3   1 
HETATM 4827 O O3   . GOL   C 3 .   ? 17.12344  -20.62026 32.00304  1.000 36.22035  ? 702 GOL   A O3   1 
HETATM 4828 H H11  . GOL   C 3 .   ? 18.06624  -19.98538 35.51064  1.000 53.16862  ? 702 GOL   A H11  1 
HETATM 4829 H H12  . GOL   C 3 .   ? 16.65658  -20.15785 36.12744  1.000 53.16862  ? 702 GOL   A H12  1 
HETATM 4830 H HO1  . GOL   C 3 .   ? 18.39601  -21.74370 36.39226  1.000 44.09035  ? 702 GOL   A HO1  1 
HETATM 4831 H H2   . GOL   C 3 .   ? 16.43262  -21.76198 34.17812  1.000 49.51808  ? 702 GOL   A H2   1 
HETATM 4832 H HO2  . GOL   C 3 .   ? 14.98627  -20.63199 33.67909  1.000 41.72294  ? 702 GOL   A HO2  1 
HETATM 4833 H H31  . GOL   C 3 .   ? 18.52458  -21.22083 33.29086  1.000 44.13468  ? 702 GOL   A H31  1 
HETATM 4834 H H32  . GOL   C 3 .   ? 18.23140  -19.70985 33.39082  1.000 44.13468  ? 702 GOL   A H32  1 
HETATM 4835 H HO3  . GOL   C 3 .   ? 16.31099  -20.43387 32.17807  1.000 43.47648  ? 702 GOL   A HO3  1 
HETATM 4836 C C1   . GOL   D 3 .   ? 2.79626   -6.47441  22.63916  1.000 34.40569  ? 703 GOL   A C1   1 
HETATM 4837 O O1   . GOL   D 3 .   ? 4.02713   -7.20907  22.62504  1.000 37.19827  ? 703 GOL   A O1   1 
HETATM 4838 C C2   . GOL   D 3 .   ? 2.78443   -5.35149  21.52244  1.000 35.49683  ? 703 GOL   A C2   1 
HETATM 4839 O O2   . GOL   D 3 .   ? 3.65378   -4.29451  21.77725  1.000 32.60195  ? 703 GOL   A O2   1 
HETATM 4840 C C3   . GOL   D 3 .   ? 3.10847   -6.05488  20.18678  1.000 39.80429  ? 703 GOL   A C3   1 
HETATM 4841 O O3   . GOL   D 3 .   ? 3.08512   -5.00643  19.21310  1.000 38.21960  ? 703 GOL   A O3   1 
HETATM 4842 H H11  . GOL   D 3 .   ? 2.64394   -6.04689  23.49644  1.000 41.29889  ? 703 GOL   A H11  1 
HETATM 4843 H H12  . GOL   D 3 .   ? 2.03191   -7.05301  22.49121  1.000 41.29889  ? 703 GOL   A H12  1 
HETATM 4844 H HO1  . GOL   D 3 .   ? 3.83341   -8.03641  22.80950  1.000 44.64998  ? 703 GOL   A HO1  1 
HETATM 4845 H H2   . GOL   D 3 .   ? 1.89803   -4.95816  21.50038  1.000 42.60825  ? 703 GOL   A H2   1 
HETATM 4846 H HO2  . GOL   D 3 .   ? 4.34011   -4.61272  22.16102  1.000 39.13440  ? 703 GOL   A HO2  1 
HETATM 4847 H H31  . GOL   D 3 .   ? 2.45976   -6.75718  20.02293  1.000 47.77720  ? 703 GOL   A H31  1 
HETATM 4848 H H32  . GOL   D 3 .   ? 3.96378   -6.50713  20.25613  1.000 47.77720  ? 703 GOL   A H32  1 
HETATM 4849 H HO3  . GOL   D 3 .   ? 3.38650   -5.33373  18.48442  1.000 45.87557  ? 703 GOL   A HO3  1 
HETATM 4850 S S    . DMS   E 4 .   ? 26.35430  0.72754   30.00020  1.000 43.04622  ? 704 DMS   A S    1 
HETATM 4851 O O    . DMS   E 4 .   ? 25.71091  0.43732   31.31159  1.000 31.28046  ? 704 DMS   A O    1 
HETATM 4852 C C1   . DMS   E 4 .   ? 26.38689  2.54590   29.89994  1.000 46.46069  ? 704 DMS   A C1   1 
HETATM 4853 C C2   . DMS   E 4 .   ? 25.05903  0.57020   28.76630  1.000 39.24608  ? 704 DMS   A C2   1 
HETATM 4854 H H11  . DMS   E 4 .   ? 27.32606  2.90168   30.23590  1.000 55.76489  ? 704 DMS   A H11  1 
HETATM 4855 H H12  . DMS   E 4 .   ? 26.23422  2.84739   28.89631  1.000 55.76489  ? 704 DMS   A H12  1 
HETATM 4856 H H13  . DMS   E 4 .   ? 25.61938  2.94735   30.50924  1.000 55.76489  ? 704 DMS   A H13  1 
HETATM 4857 H H21  . DMS   E 4 .   ? 24.43539  1.42553   28.79739  1.000 47.10735  ? 704 DMS   A H21  1 
HETATM 4858 H H22  . DMS   E 4 .   ? 25.49499  0.48658   27.80483  1.000 47.10735  ? 704 DMS   A H22  1 
HETATM 4859 H H23  . DMS   E 4 .   ? 24.48179  -0.29444  28.96801  1.000 47.10735  ? 704 DMS   A H23  1 
HETATM 4860 S S    . DMS   F 4 .   ? -7.73864  11.42922  29.44105  1.000 59.54029  ? 705 DMS   A S    1 
HETATM 4861 O O    . DMS   F 4 .   ? -8.12947  12.68483  28.72377  1.000 48.09114  ? 705 DMS   A O    1 
HETATM 4862 C C1   . DMS   F 4 .   ? -9.32355  10.73784  29.94992  1.000 44.12370  ? 705 DMS   A C1   1 
HETATM 4863 C C2   . DMS   F 4 .   ? -7.00808  11.73290  31.08255  1.000 54.00703  ? 705 DMS   A C2   1 
HETATM 4864 H H11  . DMS   F 4 .   ? -10.03016 10.86284  29.17110  1.000 52.96050  ? 705 DMS   A H11  1 
HETATM 4865 H H12  . DMS   F 4 .   ? -9.66465  11.23778  30.81894  1.000 52.96050  ? 705 DMS   A H12  1 
HETATM 4866 H H13  . DMS   F 4 .   ? -9.20835  9.70612   30.15911  1.000 52.96050  ? 705 DMS   A H13  1 
HETATM 4867 H H21  . DMS   F 4 .   ? -7.45288  12.59163  31.51407  1.000 64.82050  ? 705 DMS   A H21  1 
HETATM 4868 H H22  . DMS   F 4 .   ? -5.96543  11.88873  30.98211  1.000 64.82050  ? 705 DMS   A H22  1 
HETATM 4869 H H23  . DMS   F 4 .   ? -7.18075  10.89506  31.70682  1.000 64.82050  ? 705 DMS   A H23  1 
HETATM 4870 S S    . DMS   G 4 .   ? -0.58294  -9.42028  41.06818  1.000 65.35596  ? 706 DMS   A S    1 
HETATM 4871 O O    . DMS   G 4 .   ? -1.38657  -8.57375  40.12994  1.000 53.05783  ? 706 DMS   A O    1 
HETATM 4872 C C1   . DMS   G 4 .   ? -0.44608  -11.16055 40.55440  1.000 55.78816  ? 706 DMS   A C1   1 
HETATM 4873 C C2   . DMS   G 4 .   ? -1.52279  -9.57124  42.60599  1.000 80.50723  ? 706 DMS   A C2   1 
HETATM 4874 H H11  . DMS   G 4 .   ? -1.41413  -11.55930 40.39516  1.000 66.95784  ? 706 DMS   A H11  1 
HETATM 4875 H H12  . DMS   G 4 .   ? 0.04344   -11.71537 41.31206  1.000 66.95784  ? 706 DMS   A H12  1 
HETATM 4876 H H13  . DMS   G 4 .   ? 0.11222   -11.22121 39.65657  1.000 66.95784  ? 706 DMS   A H13  1 
HETATM 4877 H H21  . DMS   G 4 .   ? -1.76572  -10.58831 42.77343  1.000 96.62073  ? 706 DMS   A H21  1 
HETATM 4878 H H22  . DMS   G 4 .   ? -2.41371  -9.00343  42.53298  1.000 96.62073  ? 706 DMS   A H22  1 
HETATM 4879 H H23  . DMS   G 4 .   ? -0.94004  -9.21049  43.41330  1.000 96.62073  ? 706 DMS   A H23  1 
HETATM 4880 O O    . HOH   H 5 .   ? 5.55162   -9.12718  8.73391   1.000 46.73817  ? 801 HOH   A O    1 
HETATM 4881 O O    . HOH   H 5 .   ? 18.33987  0.67373   39.04725  1.000 22.86679  ? 802 HOH   A O    1 
HETATM 4882 O O    . HOH   H 5 .   ? 0.19432   2.57699   13.46407  1.000 35.55416  ? 803 HOH   A O    1 
HETATM 4883 O O    . HOH   H 5 .   ? 6.62722   -16.26488 36.17337  1.000 40.68542  ? 804 HOH   A O    1 
HETATM 4884 O O    . HOH   H 5 .   ? 10.11705  17.53423  23.47162  1.000 32.65752  ? 805 HOH   A O    1 
HETATM 4885 O O    . HOH   H 5 .   ? 10.07186  10.74696  38.49897  1.000 36.33590  ? 806 HOH   A O    1 
HETATM 4886 O O    . HOH   H 5 .   ? 0.54409   1.33772   45.75975  1.000 34.00596  ? 807 HOH   A O    1 
HETATM 4887 O O    . HOH   H 5 .   ? -4.37687  -6.61682  0.25043   1.000 46.10161  ? 808 HOH   A O    1 
HETATM 4888 O O    . HOH   H 5 .   ? 11.63470  -4.10732  51.74094  1.000 38.87803  ? 809 HOH   A O    1 
HETATM 4889 O O    . HOH   H 5 .   ? 18.99591  -8.78746  28.49439  1.000 31.52469  ? 810 HOH   A O    1 
HETATM 4890 O O    . HOH   H 5 .   ? 23.04227  -9.41031  41.13602  1.000 44.91193  ? 811 HOH   A O    1 
HETATM 4891 O O    . HOH   H 5 .   ? 17.62691  4.88264   55.09459  1.000 45.28329  ? 812 HOH   A O    1 
HETATM 4892 O O    . HOH   H 5 .   ? 16.44593  17.89195  25.21029  1.000 27.91757  ? 813 HOH   A O    1 
HETATM 4893 O O    . HOH   H 5 .   ? -3.23696  -7.66690  38.43130  1.000 31.39071  ? 814 HOH   A O    1 
HETATM 4894 O O    . HOH   H 5 .   ? 11.00575  18.01508  31.11669  1.000 41.18927  ? 815 HOH   A O    1 
HETATM 4895 O O    . HOH   H 5 .   ? 14.73595  -8.62052  42.56009  1.000 33.81251  ? 816 HOH   A O    1 
HETATM 4896 O O    . HOH   H 5 .   ? 6.53813   -1.26810  41.75061  1.000 30.20524  ? 817 HOH   A O    1 
HETATM 4897 O O    . HOH   H 5 .   ? 8.73348   -9.12407  34.74040  1.000 24.99884  ? 818 HOH   A O    1 
HETATM 4898 O O    . HOH   H 5 .   ? 19.00876  10.06546  32.15576  1.000 22.45755  ? 819 HOH   A O    1 
HETATM 4899 O O    . HOH   H 5 .   ? 0.41023   12.71677  37.15880  1.000 36.14258  ? 820 HOH   A O    1 
HETATM 4900 O O    . HOH   H 5 .   ? 20.15329  9.91662   23.20926  1.000 31.16406  ? 821 HOH   A O    1 
HETATM 4901 O O    . HOH   H 5 .   ? -9.02028  7.84828   31.84669  1.000 39.98579  ? 822 HOH   A O    1 
HETATM 4902 O O    . HOH   H 5 .   ? 12.68019  9.38960   31.33863  1.000 24.64638  ? 823 HOH   A O    1 
HETATM 4903 O O    . HOH   H 5 .   ? -5.96241  2.77297   42.03888  1.000 37.72566  ? 824 HOH   A O    1 
HETATM 4904 O O    . HOH   H 5 .   ? 13.76928  0.88530   27.60486  1.000 26.27943  ? 825 HOH   A O    1 
HETATM 4905 O O    . HOH   H 5 .   ? 12.41937  6.58615   31.55996  1.000 25.46808  ? 826 HOH   A O    1 
HETATM 4906 O O    . HOH   H 5 .   ? 1.80064   20.71324  24.00957  1.000 50.99568  ? 827 HOH   A O    1 
HETATM 4907 O O    . HOH   H 5 .   ? -8.33250  -5.01727  12.68376  1.000 42.36580  ? 828 HOH   A O    1 
HETATM 4908 O O    . HOH   H 5 .   ? 3.14469   14.48416  15.67322  1.000 39.69626  ? 829 HOH   A O    1 
HETATM 4909 O O    A HOH   H 5 .   ? 14.02572  6.53969   18.73784  0.489 27.10984  ? 830 HOH   A O    1 
HETATM 4910 O O    B HOH   H 5 .   ? 14.35626  6.72374   20.92586  0.511 23.16715  ? 830 HOH   A O    1 
HETATM 4911 O O    . HOH   H 5 .   ? 17.67157  3.44305   43.82566  1.000 40.92491  ? 831 HOH   A O    1 
HETATM 4912 O O    . HOH   H 5 .   ? 10.97777  9.40480   22.50527  1.000 34.34426  ? 832 HOH   A O    1 
HETATM 4913 O O    . HOH   H 5 .   ? 10.64242  2.98670   28.07483  1.000 24.05312  ? 833 HOH   A O    1 
HETATM 4914 O O    . HOH   H 5 .   ? 16.91908  5.34763   21.40723  1.000 25.73658  ? 834 HOH   A O    1 
HETATM 4915 O O    . HOH   H 5 .   ? -14.40589 -2.48279  31.06335  1.000 32.82082  ? 835 HOH   A O    1 
HETATM 4916 O O    . HOH   H 5 .   ? 13.44100  2.07878   39.30405  1.000 33.72359  ? 836 HOH   A O    1 
HETATM 4917 O O    . HOH   H 5 .   ? 7.429     -12.745   42.343    1.000 37.55278  ? 837 HOH   A O    1 
HETATM 4918 O O    . HOH   H 5 .   ? -2.23921  -9.40779  36.65340  1.000 29.81833  ? 838 HOH   A O    1 
HETATM 4919 O O    . HOH   H 5 .   ? -2.60624  -15.08983 14.87813  1.000 46.94973  ? 839 HOH   A O    1 
HETATM 4920 O O    . HOH   H 5 .   ? 22.16095  -10.14658 43.54641  1.000 36.33766  ? 840 HOH   A O    1 
HETATM 4921 O O    . HOH   H 5 .   ? -2.94915  -7.40067  18.27432  1.000 45.94054  ? 841 HOH   A O    1 
HETATM 4922 O O    . HOH   H 5 .   ? 20.885    -6.127    51.603    1.000 45.32722  ? 842 HOH   A O    1 
HETATM 4923 O O    . HOH   H 5 .   ? -10.01506 5.90500   32.29020  1.000 38.58829  ? 843 HOH   A O    1 
HETATM 4924 O O    . HOH   H 5 .   ? 6.13222   19.89796  32.15105  1.000 42.63826  ? 844 HOH   A O    1 
HETATM 4925 O O    . HOH   H 5 .   ? 6.10092   18.65767  16.54547  1.000 40.90428  ? 845 HOH   A O    1 
HETATM 4926 O O    . HOH   H 5 .   ? -5.00270  5.47155   45.28146  1.000 45.46661  ? 846 HOH   A O    1 
HETATM 4927 O O    . HOH   H 5 .   ? 23.88237  21.22243  33.71486  1.000 40.52685  ? 847 HOH   A O    1 
HETATM 4928 O O    . HOH   H 5 .   ? 17.74915  -4.19489  14.25724  1.000 46.62963  ? 848 HOH   A O    1 
HETATM 4929 O O    . HOH   H 5 .   ? 9.28483   -12.10360 22.10402  1.000 38.63736  ? 849 HOH   A O    1 
HETATM 4930 O O    . HOH   H 5 .   ? 2.08125   9.24960   14.18588  1.000 39.86790  ? 850 HOH   A O    1 
HETATM 4931 O O    . HOH   H 5 .   ? 22.31783  11.77829  41.45109  1.000 48.54832  ? 851 HOH   A O    1 
HETATM 4932 O O    . HOH   H 5 .   ? 9.88737   12.43675  15.52076  1.000 43.82802  ? 852 HOH   A O    1 
HETATM 4933 O O    . HOH   H 5 .   ? -7.38873  5.28780   39.84076  1.000 48.09593  ? 853 HOH   A O    1 
HETATM 4934 O O    . HOH   H 5 .   ? 27.86298  8.90715   26.63780  1.000 34.21908  ? 854 HOH   A O    1 
HETATM 4935 O O    . HOH   H 5 .   ? -15.15404 -7.64903  7.17420   1.000 46.05840  ? 855 HOH   A O    1 
HETATM 4936 O O    . HOH   H 5 .   ? 10.67654  -10.35386 35.95785  1.000 33.57489  ? 856 HOH   A O    1 
HETATM 4937 O O    . HOH   H 5 .   ? 14.36521  -16.02057 51.23858  1.000 50.53697  ? 857 HOH   A O    1 
HETATM 4938 O O    . HOH   H 5 .   ? -18.43382 -15.96980 12.99545  1.000 45.89518  ? 858 HOH   A O    1 
# 
