data_9CY1
# 
_entry.id   9CY1 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9CY1         pdb_00009cy1 10.2210/pdb9cy1/pdb 
WWPDB D_1000286413 ?            ?                   
EMDB  EMD-46004    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1  'Structure model' 1 0 2025-04-16 ? 
2  'EM metadata'     1 0 2025-04-16 ? 
3  'Half map'        1 0 2025-04-16 1 
4  'Half map'        1 0 2025-04-16 2 
5  Image             1 0 2025-04-16 ? 
6  'Primary map'     1 0 2025-04-16 ? 
7  'Structure model' 1 1 2025-04-23 ? 
8  'Structure model' 1 2 2025-05-14 ? 
9  'Structure model' 1 3 2025-05-28 ? 
10 'EM metadata'     1 1 2025-05-28 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 7  'Structure model' 'Data collection'      
2 7  'Structure model' 'Database references'  
3 8  'Structure model' 'Data collection'      
4 8  'Structure model' 'Database references'  
5 9  'Structure model' 'Data collection'      
6 10 'EM metadata'     'Data processing'      
7 10 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 7  'Structure model' citation        
2 7  'Structure model' citation_author 
3 7  'Structure model' em_admin        
4 8  'Structure model' citation        
5 8  'Structure model' em_admin        
6 9  'Structure model' em_admin        
7 9  'Structure model' em_software     
8 10 'EM metadata'     em_admin        
9 10 'EM metadata'     em_software     
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  7  'Structure model' '_citation.country'                 
2  7  'Structure model' '_citation.journal_abbrev'          
3  7  'Structure model' '_citation.journal_id_ASTM'         
4  7  'Structure model' '_citation.journal_id_CSD'          
5  7  'Structure model' '_citation.journal_id_ISSN'         
6  7  'Structure model' '_citation.page_first'              
7  7  'Structure model' '_citation.page_last'               
8  7  'Structure model' '_citation.pdbx_database_id_DOI'    
9  7  'Structure model' '_citation.pdbx_database_id_PubMed' 
10 7  'Structure model' '_citation.title'                   
11 7  'Structure model' '_citation.year'                    
12 7  'Structure model' '_citation_author.identifier_ORCID' 
13 7  'Structure model' '_em_admin.last_update'             
14 8  'Structure model' '_citation.journal_volume'          
15 8  'Structure model' '_em_admin.last_update'             
16 9  'Structure model' '_em_admin.last_update'             
17 9  'Structure model' '_em_software.name'                 
18 10 'EM metadata'     '_em_admin.last_update'             
19 10 'EM metadata'     '_em_software.name'                 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9CY1 
_pdbx_database_status.recvd_initial_deposition_date   2024-08-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Outward-facing OATP1B1 bound to sybody Sb5' 
_pdbx_database_related.db_id          EMD-46004 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              seungil.han@pfizer.com 
_pdbx_contact_author.name_first         Seungil 
_pdbx_contact_author.name_last          Han 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1070-3880 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sung, M.W.' 1 0000-0001-6553-6373 
'Lees, J.A.' 2 0000-0001-7421-6881 
'Han, S.'    3 0000-0002-1070-3880 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            J.Biol.Chem. 
_citation.journal_id_ASTM           JBCHA3 
_citation.journal_id_CSD            0071 
_citation.journal_id_ISSN           1083-351X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            301 
_citation.language                  ? 
_citation.page_first                108484 
_citation.page_last                 108484 
_citation.title                     'Cyclosporine A sterically inhibits statin transport by solute carrier OATP1B1.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.jbc.2025.108484 
_citation.pdbx_database_id_PubMed   40199401 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Sung, M.W.'      1  ? 
primary 'Hu, K.'          2  ? 
primary 'Hurlimann, L.M.' 3  ? 
primary 'Lees, J.A.'      4  ? 
primary 'Fennell, K.F.'   5  ? 
primary 'West, M.A.'      6  ? 
primary 'Costales, C.'    7  ? 
primary 'Rodrigues, A.D.' 8  ? 
primary 'Zimmermann, I.'  9  ? 
primary 'Dawson, R.J.P.'  10 ? 
primary 'Liu, S.'         11 ? 
primary 'Han, S.'         12 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Solute carrier organic anion transporter family member 1B1' 79880.977 1 ? ? ? ? 
2 polymer man 'Sybody 5'                                                   15885.510 1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;SLCO1B1,Liver-specific organic anion transporter 1,LST-1,OATP-C,Organic anion transporter SLC21A6,Sodium-independent organic anion-transporting polypeptide 2,OATP-2,Solute carrier family 21 member 6
;
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MHHHHHHHHHHDYKDDDDKENLYFQGMDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIH
IERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSEN
STSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNA
IAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASL
SLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKA
NILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDV
PLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKF
YFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCR
TYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
;
;MHHHHHHHHHHDYKDDDDKENLYFQGMDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIH
IERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSEN
STSTLSTCLINQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNA
IAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASL
SLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKA
NILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDV
PLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKF
YFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCR
TYNSTSFSRVYLGLSSMLRVSSLVLYIILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
;
A ? 
2 'polypeptide(L)' no no 
;GSSSQVQLVESGGGLVQAGGSLRLSCAASGFPVNLSYMHWYRQAPGKEREWVAAISSWGWHTEYADSVKGRFTISRDNAK
NTVYLQMNSLKPEDTAVYYCHVRVGRSYFGQGTQVSVSAGRAGEQKLISEEDLNSAVDHHHHHH
;
;GSSSQVQLVESGGGLVQAGGSLRLSCAASGFPVNLSYMHWYRQAPGKEREWVAAISSWGWHTEYADSVKGRFTISRDNAK
NTVYLQMNSLKPEDTAVYYCHVRVGRSYFGQGTQVSVSAGRAGEQKLISEEDLNSAVDHHHHHH
;
B ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   HIS n 
1 9   HIS n 
1 10  HIS n 
1 11  HIS n 
1 12  ASP n 
1 13  TYR n 
1 14  LYS n 
1 15  ASP n 
1 16  ASP n 
1 17  ASP n 
1 18  ASP n 
1 19  LYS n 
1 20  GLU n 
1 21  ASN n 
1 22  LEU n 
1 23  TYR n 
1 24  PHE n 
1 25  GLN n 
1 26  GLY n 
1 27  MET n 
1 28  ASP n 
1 29  GLN n 
1 30  ASN n 
1 31  GLN n 
1 32  HIS n 
1 33  LEU n 
1 34  ASN n 
1 35  LYS n 
1 36  THR n 
1 37  ALA n 
1 38  GLU n 
1 39  ALA n 
1 40  GLN n 
1 41  PRO n 
1 42  SER n 
1 43  GLU n 
1 44  ASN n 
1 45  LYS n 
1 46  LYS n 
1 47  THR n 
1 48  ARG n 
1 49  TYR n 
1 50  CYS n 
1 51  ASN n 
1 52  GLY n 
1 53  LEU n 
1 54  LYS n 
1 55  MET n 
1 56  PHE n 
1 57  LEU n 
1 58  ALA n 
1 59  ALA n 
1 60  LEU n 
1 61  SER n 
1 62  LEU n 
1 63  SER n 
1 64  PHE n 
1 65  ILE n 
1 66  ALA n 
1 67  LYS n 
1 68  THR n 
1 69  LEU n 
1 70  GLY n 
1 71  ALA n 
1 72  ILE n 
1 73  ILE n 
1 74  MET n 
1 75  LYS n 
1 76  SER n 
1 77  SER n 
1 78  ILE n 
1 79  ILE n 
1 80  HIS n 
1 81  ILE n 
1 82  GLU n 
1 83  ARG n 
1 84  ARG n 
1 85  PHE n 
1 86  GLU n 
1 87  ILE n 
1 88  SER n 
1 89  SER n 
1 90  SER n 
1 91  LEU n 
1 92  VAL n 
1 93  GLY n 
1 94  PHE n 
1 95  ILE n 
1 96  ASP n 
1 97  GLY n 
1 98  SER n 
1 99  PHE n 
1 100 GLU n 
1 101 ILE n 
1 102 GLY n 
1 103 ASN n 
1 104 LEU n 
1 105 LEU n 
1 106 VAL n 
1 107 ILE n 
1 108 VAL n 
1 109 PHE n 
1 110 VAL n 
1 111 SER n 
1 112 TYR n 
1 113 PHE n 
1 114 GLY n 
1 115 SER n 
1 116 LYS n 
1 117 LEU n 
1 118 HIS n 
1 119 ARG n 
1 120 PRO n 
1 121 LYS n 
1 122 LEU n 
1 123 ILE n 
1 124 GLY n 
1 125 ILE n 
1 126 GLY n 
1 127 CYS n 
1 128 PHE n 
1 129 ILE n 
1 130 MET n 
1 131 GLY n 
1 132 ILE n 
1 133 GLY n 
1 134 GLY n 
1 135 VAL n 
1 136 LEU n 
1 137 THR n 
1 138 ALA n 
1 139 LEU n 
1 140 PRO n 
1 141 HIS n 
1 142 PHE n 
1 143 PHE n 
1 144 MET n 
1 145 GLY n 
1 146 TYR n 
1 147 TYR n 
1 148 ARG n 
1 149 TYR n 
1 150 SER n 
1 151 LYS n 
1 152 GLU n 
1 153 THR n 
1 154 ASN n 
1 155 ILE n 
1 156 ASN n 
1 157 SER n 
1 158 SER n 
1 159 GLU n 
1 160 ASN n 
1 161 SER n 
1 162 THR n 
1 163 SER n 
1 164 THR n 
1 165 LEU n 
1 166 SER n 
1 167 THR n 
1 168 CYS n 
1 169 LEU n 
1 170 ILE n 
1 171 ASN n 
1 172 GLN n 
1 173 ILE n 
1 174 LEU n 
1 175 SER n 
1 176 LEU n 
1 177 ASN n 
1 178 ARG n 
1 179 ALA n 
1 180 SER n 
1 181 PRO n 
1 182 GLU n 
1 183 ILE n 
1 184 VAL n 
1 185 GLY n 
1 186 LYS n 
1 187 GLY n 
1 188 CYS n 
1 189 LEU n 
1 190 LYS n 
1 191 GLU n 
1 192 SER n 
1 193 GLY n 
1 194 SER n 
1 195 TYR n 
1 196 MET n 
1 197 TRP n 
1 198 ILE n 
1 199 TYR n 
1 200 VAL n 
1 201 PHE n 
1 202 MET n 
1 203 GLY n 
1 204 ASN n 
1 205 MET n 
1 206 LEU n 
1 207 ARG n 
1 208 GLY n 
1 209 ILE n 
1 210 GLY n 
1 211 GLU n 
1 212 THR n 
1 213 PRO n 
1 214 ILE n 
1 215 VAL n 
1 216 PRO n 
1 217 LEU n 
1 218 GLY n 
1 219 LEU n 
1 220 SER n 
1 221 TYR n 
1 222 ILE n 
1 223 ASP n 
1 224 ASP n 
1 225 PHE n 
1 226 ALA n 
1 227 LYS n 
1 228 GLU n 
1 229 GLY n 
1 230 HIS n 
1 231 SER n 
1 232 SER n 
1 233 LEU n 
1 234 TYR n 
1 235 LEU n 
1 236 GLY n 
1 237 ILE n 
1 238 LEU n 
1 239 ASN n 
1 240 ALA n 
1 241 ILE n 
1 242 ALA n 
1 243 MET n 
1 244 ILE n 
1 245 GLY n 
1 246 PRO n 
1 247 ILE n 
1 248 ILE n 
1 249 GLY n 
1 250 PHE n 
1 251 THR n 
1 252 LEU n 
1 253 GLY n 
1 254 SER n 
1 255 LEU n 
1 256 PHE n 
1 257 SER n 
1 258 LYS n 
1 259 MET n 
1 260 TYR n 
1 261 VAL n 
1 262 ASP n 
1 263 ILE n 
1 264 GLY n 
1 265 TYR n 
1 266 VAL n 
1 267 ASP n 
1 268 LEU n 
1 269 SER n 
1 270 THR n 
1 271 ILE n 
1 272 ARG n 
1 273 ILE n 
1 274 THR n 
1 275 PRO n 
1 276 THR n 
1 277 ASP n 
1 278 SER n 
1 279 ARG n 
1 280 TRP n 
1 281 VAL n 
1 282 GLY n 
1 283 ALA n 
1 284 TRP n 
1 285 TRP n 
1 286 LEU n 
1 287 ASN n 
1 288 PHE n 
1 289 LEU n 
1 290 VAL n 
1 291 SER n 
1 292 GLY n 
1 293 LEU n 
1 294 PHE n 
1 295 SER n 
1 296 ILE n 
1 297 ILE n 
1 298 SER n 
1 299 SER n 
1 300 ILE n 
1 301 PRO n 
1 302 PHE n 
1 303 PHE n 
1 304 PHE n 
1 305 LEU n 
1 306 PRO n 
1 307 GLN n 
1 308 THR n 
1 309 PRO n 
1 310 ASN n 
1 311 LYS n 
1 312 PRO n 
1 313 GLN n 
1 314 LYS n 
1 315 GLU n 
1 316 ARG n 
1 317 LYS n 
1 318 ALA n 
1 319 SER n 
1 320 LEU n 
1 321 SER n 
1 322 LEU n 
1 323 HIS n 
1 324 VAL n 
1 325 LEU n 
1 326 GLU n 
1 327 THR n 
1 328 ASN n 
1 329 ASP n 
1 330 GLU n 
1 331 LYS n 
1 332 ASP n 
1 333 GLN n 
1 334 THR n 
1 335 ALA n 
1 336 ASN n 
1 337 LEU n 
1 338 THR n 
1 339 ASN n 
1 340 GLN n 
1 341 GLY n 
1 342 LYS n 
1 343 ASN n 
1 344 ILE n 
1 345 THR n 
1 346 LYS n 
1 347 ASN n 
1 348 VAL n 
1 349 THR n 
1 350 GLY n 
1 351 PHE n 
1 352 PHE n 
1 353 GLN n 
1 354 SER n 
1 355 PHE n 
1 356 LYS n 
1 357 SER n 
1 358 ILE n 
1 359 LEU n 
1 360 THR n 
1 361 ASN n 
1 362 PRO n 
1 363 LEU n 
1 364 TYR n 
1 365 VAL n 
1 366 MET n 
1 367 PHE n 
1 368 VAL n 
1 369 LEU n 
1 370 LEU n 
1 371 THR n 
1 372 LEU n 
1 373 LEU n 
1 374 GLN n 
1 375 VAL n 
1 376 SER n 
1 377 SER n 
1 378 TYR n 
1 379 ILE n 
1 380 GLY n 
1 381 ALA n 
1 382 PHE n 
1 383 THR n 
1 384 TYR n 
1 385 VAL n 
1 386 PHE n 
1 387 LYS n 
1 388 TYR n 
1 389 VAL n 
1 390 GLU n 
1 391 GLN n 
1 392 GLN n 
1 393 TYR n 
1 394 GLY n 
1 395 GLN n 
1 396 PRO n 
1 397 SER n 
1 398 SER n 
1 399 LYS n 
1 400 ALA n 
1 401 ASN n 
1 402 ILE n 
1 403 LEU n 
1 404 LEU n 
1 405 GLY n 
1 406 VAL n 
1 407 ILE n 
1 408 THR n 
1 409 ILE n 
1 410 PRO n 
1 411 ILE n 
1 412 PHE n 
1 413 ALA n 
1 414 SER n 
1 415 GLY n 
1 416 MET n 
1 417 PHE n 
1 418 LEU n 
1 419 GLY n 
1 420 GLY n 
1 421 TYR n 
1 422 ILE n 
1 423 ILE n 
1 424 LYS n 
1 425 LYS n 
1 426 PHE n 
1 427 LYS n 
1 428 LEU n 
1 429 ASN n 
1 430 THR n 
1 431 VAL n 
1 432 GLY n 
1 433 ILE n 
1 434 ALA n 
1 435 LYS n 
1 436 PHE n 
1 437 SER n 
1 438 CYS n 
1 439 PHE n 
1 440 THR n 
1 441 ALA n 
1 442 VAL n 
1 443 MET n 
1 444 SER n 
1 445 LEU n 
1 446 SER n 
1 447 PHE n 
1 448 TYR n 
1 449 LEU n 
1 450 LEU n 
1 451 TYR n 
1 452 PHE n 
1 453 PHE n 
1 454 ILE n 
1 455 LEU n 
1 456 CYS n 
1 457 GLU n 
1 458 ASN n 
1 459 LYS n 
1 460 SER n 
1 461 VAL n 
1 462 ALA n 
1 463 GLY n 
1 464 LEU n 
1 465 THR n 
1 466 MET n 
1 467 THR n 
1 468 TYR n 
1 469 ASP n 
1 470 GLY n 
1 471 ASN n 
1 472 ASN n 
1 473 PRO n 
1 474 VAL n 
1 475 THR n 
1 476 SER n 
1 477 HIS n 
1 478 ARG n 
1 479 ASP n 
1 480 VAL n 
1 481 PRO n 
1 482 LEU n 
1 483 SER n 
1 484 TYR n 
1 485 CYS n 
1 486 ASN n 
1 487 SER n 
1 488 ASP n 
1 489 CYS n 
1 490 ASN n 
1 491 CYS n 
1 492 ASP n 
1 493 GLU n 
1 494 SER n 
1 495 GLN n 
1 496 TRP n 
1 497 GLU n 
1 498 PRO n 
1 499 VAL n 
1 500 CYS n 
1 501 GLY n 
1 502 ASN n 
1 503 ASN n 
1 504 GLY n 
1 505 ILE n 
1 506 THR n 
1 507 TYR n 
1 508 ILE n 
1 509 SER n 
1 510 PRO n 
1 511 CYS n 
1 512 LEU n 
1 513 ALA n 
1 514 GLY n 
1 515 CYS n 
1 516 LYS n 
1 517 SER n 
1 518 SER n 
1 519 SER n 
1 520 GLY n 
1 521 ASN n 
1 522 LYS n 
1 523 LYS n 
1 524 PRO n 
1 525 ILE n 
1 526 VAL n 
1 527 PHE n 
1 528 TYR n 
1 529 ASN n 
1 530 CYS n 
1 531 SER n 
1 532 CYS n 
1 533 LEU n 
1 534 GLU n 
1 535 VAL n 
1 536 THR n 
1 537 GLY n 
1 538 LEU n 
1 539 GLN n 
1 540 ASN n 
1 541 ARG n 
1 542 ASN n 
1 543 TYR n 
1 544 SER n 
1 545 ALA n 
1 546 HIS n 
1 547 LEU n 
1 548 GLY n 
1 549 GLU n 
1 550 CYS n 
1 551 PRO n 
1 552 ARG n 
1 553 ASP n 
1 554 ASP n 
1 555 ALA n 
1 556 CYS n 
1 557 THR n 
1 558 ARG n 
1 559 LYS n 
1 560 PHE n 
1 561 TYR n 
1 562 PHE n 
1 563 PHE n 
1 564 VAL n 
1 565 ALA n 
1 566 ILE n 
1 567 GLN n 
1 568 VAL n 
1 569 LEU n 
1 570 ASN n 
1 571 LEU n 
1 572 PHE n 
1 573 PHE n 
1 574 SER n 
1 575 ALA n 
1 576 LEU n 
1 577 GLY n 
1 578 GLY n 
1 579 THR n 
1 580 SER n 
1 581 HIS n 
1 582 VAL n 
1 583 MET n 
1 584 LEU n 
1 585 ILE n 
1 586 VAL n 
1 587 LYS n 
1 588 ILE n 
1 589 VAL n 
1 590 GLN n 
1 591 PRO n 
1 592 GLU n 
1 593 LEU n 
1 594 LYS n 
1 595 SER n 
1 596 LEU n 
1 597 ALA n 
1 598 LEU n 
1 599 GLY n 
1 600 PHE n 
1 601 HIS n 
1 602 SER n 
1 603 MET n 
1 604 VAL n 
1 605 ILE n 
1 606 ARG n 
1 607 ALA n 
1 608 LEU n 
1 609 GLY n 
1 610 GLY n 
1 611 ILE n 
1 612 LEU n 
1 613 ALA n 
1 614 PRO n 
1 615 ILE n 
1 616 TYR n 
1 617 PHE n 
1 618 GLY n 
1 619 ALA n 
1 620 LEU n 
1 621 ILE n 
1 622 ASP n 
1 623 THR n 
1 624 THR n 
1 625 CYS n 
1 626 ILE n 
1 627 LYS n 
1 628 TRP n 
1 629 SER n 
1 630 THR n 
1 631 ASN n 
1 632 ASN n 
1 633 CYS n 
1 634 GLY n 
1 635 THR n 
1 636 ARG n 
1 637 GLY n 
1 638 SER n 
1 639 CYS n 
1 640 ARG n 
1 641 THR n 
1 642 TYR n 
1 643 ASN n 
1 644 SER n 
1 645 THR n 
1 646 SER n 
1 647 PHE n 
1 648 SER n 
1 649 ARG n 
1 650 VAL n 
1 651 TYR n 
1 652 LEU n 
1 653 GLY n 
1 654 LEU n 
1 655 SER n 
1 656 SER n 
1 657 MET n 
1 658 LEU n 
1 659 ARG n 
1 660 VAL n 
1 661 SER n 
1 662 SER n 
1 663 LEU n 
1 664 VAL n 
1 665 LEU n 
1 666 TYR n 
1 667 ILE n 
1 668 ILE n 
1 669 LEU n 
1 670 ILE n 
1 671 TYR n 
1 672 ALA n 
1 673 MET n 
1 674 LYS n 
1 675 LYS n 
1 676 LYS n 
1 677 TYR n 
1 678 GLN n 
1 679 GLU n 
1 680 LYS n 
1 681 ASP n 
1 682 ILE n 
1 683 ASN n 
1 684 ALA n 
1 685 SER n 
1 686 GLU n 
1 687 ASN n 
1 688 GLY n 
1 689 SER n 
1 690 VAL n 
1 691 MET n 
1 692 ASP n 
1 693 GLU n 
1 694 ALA n 
1 695 ASN n 
1 696 LEU n 
1 697 GLU n 
1 698 SER n 
1 699 LEU n 
1 700 ASN n 
1 701 LYS n 
1 702 ASN n 
1 703 LYS n 
1 704 HIS n 
1 705 PHE n 
1 706 VAL n 
1 707 PRO n 
1 708 SER n 
1 709 ALA n 
1 710 GLY n 
1 711 ALA n 
1 712 ASP n 
1 713 SER n 
1 714 GLU n 
1 715 THR n 
1 716 HIS n 
1 717 CYS n 
2 1   GLY n 
2 2   SER n 
2 3   SER n 
2 4   SER n 
2 5   GLN n 
2 6   VAL n 
2 7   GLN n 
2 8   LEU n 
2 9   VAL n 
2 10  GLU n 
2 11  SER n 
2 12  GLY n 
2 13  GLY n 
2 14  GLY n 
2 15  LEU n 
2 16  VAL n 
2 17  GLN n 
2 18  ALA n 
2 19  GLY n 
2 20  GLY n 
2 21  SER n 
2 22  LEU n 
2 23  ARG n 
2 24  LEU n 
2 25  SER n 
2 26  CYS n 
2 27  ALA n 
2 28  ALA n 
2 29  SER n 
2 30  GLY n 
2 31  PHE n 
2 32  PRO n 
2 33  VAL n 
2 34  ASN n 
2 35  LEU n 
2 36  SER n 
2 37  TYR n 
2 38  MET n 
2 39  HIS n 
2 40  TRP n 
2 41  TYR n 
2 42  ARG n 
2 43  GLN n 
2 44  ALA n 
2 45  PRO n 
2 46  GLY n 
2 47  LYS n 
2 48  GLU n 
2 49  ARG n 
2 50  GLU n 
2 51  TRP n 
2 52  VAL n 
2 53  ALA n 
2 54  ALA n 
2 55  ILE n 
2 56  SER n 
2 57  SER n 
2 58  TRP n 
2 59  GLY n 
2 60  TRP n 
2 61  HIS n 
2 62  THR n 
2 63  GLU n 
2 64  TYR n 
2 65  ALA n 
2 66  ASP n 
2 67  SER n 
2 68  VAL n 
2 69  LYS n 
2 70  GLY n 
2 71  ARG n 
2 72  PHE n 
2 73  THR n 
2 74  ILE n 
2 75  SER n 
2 76  ARG n 
2 77  ASP n 
2 78  ASN n 
2 79  ALA n 
2 80  LYS n 
2 81  ASN n 
2 82  THR n 
2 83  VAL n 
2 84  TYR n 
2 85  LEU n 
2 86  GLN n 
2 87  MET n 
2 88  ASN n 
2 89  SER n 
2 90  LEU n 
2 91  LYS n 
2 92  PRO n 
2 93  GLU n 
2 94  ASP n 
2 95  THR n 
2 96  ALA n 
2 97  VAL n 
2 98  TYR n 
2 99  TYR n 
2 100 CYS n 
2 101 HIS n 
2 102 VAL n 
2 103 ARG n 
2 104 VAL n 
2 105 GLY n 
2 106 ARG n 
2 107 SER n 
2 108 TYR n 
2 109 PHE n 
2 110 GLY n 
2 111 GLN n 
2 112 GLY n 
2 113 THR n 
2 114 GLN n 
2 115 VAL n 
2 116 SER n 
2 117 VAL n 
2 118 SER n 
2 119 ALA n 
2 120 GLY n 
2 121 ARG n 
2 122 ALA n 
2 123 GLY n 
2 124 GLU n 
2 125 GLN n 
2 126 LYS n 
2 127 LEU n 
2 128 ILE n 
2 129 SER n 
2 130 GLU n 
2 131 GLU n 
2 132 ASP n 
2 133 LEU n 
2 134 ASN n 
2 135 SER n 
2 136 ALA n 
2 137 VAL n 
2 138 ASP n 
2 139 HIS n 
2 140 HIS n 
2 141 HIS n 
2 142 HIS n 
2 143 HIS n 
2 144 HIS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 717 human ? 'SLCO1B1, LST1, OATP1B1, OATP2, OATPC, SLC21A6' ? ? ? ? ? ? 'Homo sapiens'        
9606  ? ? ? ? ? ? ? human 'Homo sapiens'     9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 144 ?     ? ?                                               ? ? ? ? ? ? 'synthetic construct' 
32630 ? ? ? ? ? ? ? ?     'Escherichia coli' 562  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -25 ?   ?   ?   A . n 
A 1 2   HIS 2   -24 ?   ?   ?   A . n 
A 1 3   HIS 3   -23 ?   ?   ?   A . n 
A 1 4   HIS 4   -22 ?   ?   ?   A . n 
A 1 5   HIS 5   -21 ?   ?   ?   A . n 
A 1 6   HIS 6   -20 ?   ?   ?   A . n 
A 1 7   HIS 7   -19 ?   ?   ?   A . n 
A 1 8   HIS 8   -18 ?   ?   ?   A . n 
A 1 9   HIS 9   -17 ?   ?   ?   A . n 
A 1 10  HIS 10  -16 ?   ?   ?   A . n 
A 1 11  HIS 11  -15 ?   ?   ?   A . n 
A 1 12  ASP 12  -14 ?   ?   ?   A . n 
A 1 13  TYR 13  -13 ?   ?   ?   A . n 
A 1 14  LYS 14  -12 ?   ?   ?   A . n 
A 1 15  ASP 15  -11 ?   ?   ?   A . n 
A 1 16  ASP 16  -10 ?   ?   ?   A . n 
A 1 17  ASP 17  -9  ?   ?   ?   A . n 
A 1 18  ASP 18  -8  ?   ?   ?   A . n 
A 1 19  LYS 19  -7  ?   ?   ?   A . n 
A 1 20  GLU 20  -6  ?   ?   ?   A . n 
A 1 21  ASN 21  -5  ?   ?   ?   A . n 
A 1 22  LEU 22  -4  ?   ?   ?   A . n 
A 1 23  TYR 23  -3  ?   ?   ?   A . n 
A 1 24  PHE 24  -2  ?   ?   ?   A . n 
A 1 25  GLN 25  -1  ?   ?   ?   A . n 
A 1 26  GLY 26  0   ?   ?   ?   A . n 
A 1 27  MET 27  1   ?   ?   ?   A . n 
A 1 28  ASP 28  2   ?   ?   ?   A . n 
A 1 29  GLN 29  3   ?   ?   ?   A . n 
A 1 30  ASN 30  4   ?   ?   ?   A . n 
A 1 31  GLN 31  5   ?   ?   ?   A . n 
A 1 32  HIS 32  6   ?   ?   ?   A . n 
A 1 33  LEU 33  7   ?   ?   ?   A . n 
A 1 34  ASN 34  8   ?   ?   ?   A . n 
A 1 35  LYS 35  9   ?   ?   ?   A . n 
A 1 36  THR 36  10  ?   ?   ?   A . n 
A 1 37  ALA 37  11  ?   ?   ?   A . n 
A 1 38  GLU 38  12  ?   ?   ?   A . n 
A 1 39  ALA 39  13  ?   ?   ?   A . n 
A 1 40  GLN 40  14  ?   ?   ?   A . n 
A 1 41  PRO 41  15  ?   ?   ?   A . n 
A 1 42  SER 42  16  ?   ?   ?   A . n 
A 1 43  GLU 43  17  ?   ?   ?   A . n 
A 1 44  ASN 44  18  ?   ?   ?   A . n 
A 1 45  LYS 45  19  ?   ?   ?   A . n 
A 1 46  LYS 46  20  ?   ?   ?   A . n 
A 1 47  THR 47  21  ?   ?   ?   A . n 
A 1 48  ARG 48  22  ?   ?   ?   A . n 
A 1 49  TYR 49  23  ?   ?   ?   A . n 
A 1 50  CYS 50  24  24  CYS CYS A . n 
A 1 51  ASN 51  25  25  ASN ASN A . n 
A 1 52  GLY 52  26  26  GLY GLY A . n 
A 1 53  LEU 53  27  27  LEU LEU A . n 
A 1 54  LYS 54  28  28  LYS LYS A . n 
A 1 55  MET 55  29  29  MET MET A . n 
A 1 56  PHE 56  30  30  PHE PHE A . n 
A 1 57  LEU 57  31  31  LEU LEU A . n 
A 1 58  ALA 58  32  32  ALA ALA A . n 
A 1 59  ALA 59  33  33  ALA ALA A . n 
A 1 60  LEU 60  34  34  LEU LEU A . n 
A 1 61  SER 61  35  35  SER SER A . n 
A 1 62  LEU 62  36  36  LEU LEU A . n 
A 1 63  SER 63  37  37  SER SER A . n 
A 1 64  PHE 64  38  38  PHE PHE A . n 
A 1 65  ILE 65  39  39  ILE ILE A . n 
A 1 66  ALA 66  40  40  ALA ALA A . n 
A 1 67  LYS 67  41  41  LYS LYS A . n 
A 1 68  THR 68  42  42  THR THR A . n 
A 1 69  LEU 69  43  43  LEU LEU A . n 
A 1 70  GLY 70  44  44  GLY GLY A . n 
A 1 71  ALA 71  45  45  ALA ALA A . n 
A 1 72  ILE 72  46  46  ILE ILE A . n 
A 1 73  ILE 73  47  47  ILE ILE A . n 
A 1 74  MET 74  48  48  MET MET A . n 
A 1 75  LYS 75  49  49  LYS LYS A . n 
A 1 76  SER 76  50  50  SER SER A . n 
A 1 77  SER 77  51  51  SER SER A . n 
A 1 78  ILE 78  52  52  ILE ILE A . n 
A 1 79  ILE 79  53  53  ILE ILE A . n 
A 1 80  HIS 80  54  54  HIS HIS A . n 
A 1 81  ILE 81  55  55  ILE ILE A . n 
A 1 82  GLU 82  56  56  GLU GLU A . n 
A 1 83  ARG 83  57  57  ARG ARG A . n 
A 1 84  ARG 84  58  58  ARG ARG A . n 
A 1 85  PHE 85  59  59  PHE PHE A . n 
A 1 86  GLU 86  60  60  GLU GLU A . n 
A 1 87  ILE 87  61  61  ILE ILE A . n 
A 1 88  SER 88  62  62  SER SER A . n 
A 1 89  SER 89  63  63  SER SER A . n 
A 1 90  SER 90  64  64  SER SER A . n 
A 1 91  LEU 91  65  65  LEU LEU A . n 
A 1 92  VAL 92  66  66  VAL VAL A . n 
A 1 93  GLY 93  67  67  GLY GLY A . n 
A 1 94  PHE 94  68  68  PHE PHE A . n 
A 1 95  ILE 95  69  69  ILE ILE A . n 
A 1 96  ASP 96  70  70  ASP ASP A . n 
A 1 97  GLY 97  71  71  GLY GLY A . n 
A 1 98  SER 98  72  72  SER SER A . n 
A 1 99  PHE 99  73  73  PHE PHE A . n 
A 1 100 GLU 100 74  74  GLU GLU A . n 
A 1 101 ILE 101 75  75  ILE ILE A . n 
A 1 102 GLY 102 76  76  GLY GLY A . n 
A 1 103 ASN 103 77  77  ASN ASN A . n 
A 1 104 LEU 104 78  78  LEU LEU A . n 
A 1 105 LEU 105 79  79  LEU LEU A . n 
A 1 106 VAL 106 80  80  VAL VAL A . n 
A 1 107 ILE 107 81  81  ILE ILE A . n 
A 1 108 VAL 108 82  82  VAL VAL A . n 
A 1 109 PHE 109 83  83  PHE PHE A . n 
A 1 110 VAL 110 84  84  VAL VAL A . n 
A 1 111 SER 111 85  85  SER SER A . n 
A 1 112 TYR 112 86  86  TYR TYR A . n 
A 1 113 PHE 113 87  87  PHE PHE A . n 
A 1 114 GLY 114 88  88  GLY GLY A . n 
A 1 115 SER 115 89  89  SER SER A . n 
A 1 116 LYS 116 90  90  LYS LYS A . n 
A 1 117 LEU 117 91  91  LEU LEU A . n 
A 1 118 HIS 118 92  92  HIS HIS A . n 
A 1 119 ARG 119 93  93  ARG ARG A . n 
A 1 120 PRO 120 94  94  PRO PRO A . n 
A 1 121 LYS 121 95  95  LYS LYS A . n 
A 1 122 LEU 122 96  96  LEU LEU A . n 
A 1 123 ILE 123 97  97  ILE ILE A . n 
A 1 124 GLY 124 98  98  GLY GLY A . n 
A 1 125 ILE 125 99  99  ILE ILE A . n 
A 1 126 GLY 126 100 100 GLY GLY A . n 
A 1 127 CYS 127 101 101 CYS CYS A . n 
A 1 128 PHE 128 102 102 PHE PHE A . n 
A 1 129 ILE 129 103 103 ILE ILE A . n 
A 1 130 MET 130 104 104 MET MET A . n 
A 1 131 GLY 131 105 105 GLY GLY A . n 
A 1 132 ILE 132 106 106 ILE ILE A . n 
A 1 133 GLY 133 107 107 GLY GLY A . n 
A 1 134 GLY 134 108 108 GLY GLY A . n 
A 1 135 VAL 135 109 109 VAL VAL A . n 
A 1 136 LEU 136 110 110 LEU LEU A . n 
A 1 137 THR 137 111 111 THR THR A . n 
A 1 138 ALA 138 112 112 ALA ALA A . n 
A 1 139 LEU 139 113 113 LEU LEU A . n 
A 1 140 PRO 140 114 114 PRO PRO A . n 
A 1 141 HIS 141 115 115 HIS HIS A . n 
A 1 142 PHE 142 116 116 PHE PHE A . n 
A 1 143 PHE 143 117 117 PHE PHE A . n 
A 1 144 MET 144 118 118 MET MET A . n 
A 1 145 GLY 145 119 119 GLY GLY A . n 
A 1 146 TYR 146 120 120 TYR TYR A . n 
A 1 147 TYR 147 121 121 TYR TYR A . n 
A 1 148 ARG 148 122 122 ARG ARG A . n 
A 1 149 TYR 149 123 123 TYR TYR A . n 
A 1 150 SER 150 124 124 SER SER A . n 
A 1 151 LYS 151 125 ?   ?   ?   A . n 
A 1 152 GLU 152 126 ?   ?   ?   A . n 
A 1 153 THR 153 127 ?   ?   ?   A . n 
A 1 154 ASN 154 128 ?   ?   ?   A . n 
A 1 155 ILE 155 129 ?   ?   ?   A . n 
A 1 156 ASN 156 130 ?   ?   ?   A . n 
A 1 157 SER 157 131 ?   ?   ?   A . n 
A 1 158 SER 158 132 ?   ?   ?   A . n 
A 1 159 GLU 159 133 ?   ?   ?   A . n 
A 1 160 ASN 160 134 ?   ?   ?   A . n 
A 1 161 SER 161 135 ?   ?   ?   A . n 
A 1 162 THR 162 136 ?   ?   ?   A . n 
A 1 163 SER 163 137 ?   ?   ?   A . n 
A 1 164 THR 164 138 138 THR THR A . n 
A 1 165 LEU 165 139 139 LEU LEU A . n 
A 1 166 SER 166 140 140 SER SER A . n 
A 1 167 THR 167 141 141 THR THR A . n 
A 1 168 CYS 168 142 142 CYS CYS A . n 
A 1 169 LEU 169 143 143 LEU LEU A . n 
A 1 170 ILE 170 144 144 ILE ILE A . n 
A 1 171 ASN 171 145 ?   ?   ?   A . n 
A 1 172 GLN 172 146 ?   ?   ?   A . n 
A 1 173 ILE 173 147 ?   ?   ?   A . n 
A 1 174 LEU 174 148 ?   ?   ?   A . n 
A 1 175 SER 175 149 ?   ?   ?   A . n 
A 1 176 LEU 176 150 ?   ?   ?   A . n 
A 1 177 ASN 177 151 ?   ?   ?   A . n 
A 1 178 ARG 178 152 ?   ?   ?   A . n 
A 1 179 ALA 179 153 ?   ?   ?   A . n 
A 1 180 SER 180 154 ?   ?   ?   A . n 
A 1 181 PRO 181 155 ?   ?   ?   A . n 
A 1 182 GLU 182 156 ?   ?   ?   A . n 
A 1 183 ILE 183 157 ?   ?   ?   A . n 
A 1 184 VAL 184 158 ?   ?   ?   A . n 
A 1 185 GLY 185 159 ?   ?   ?   A . n 
A 1 186 LYS 186 160 ?   ?   ?   A . n 
A 1 187 GLY 187 161 ?   ?   ?   A . n 
A 1 188 CYS 188 162 ?   ?   ?   A . n 
A 1 189 LEU 189 163 ?   ?   ?   A . n 
A 1 190 LYS 190 164 ?   ?   ?   A . n 
A 1 191 GLU 191 165 ?   ?   ?   A . n 
A 1 192 SER 192 166 ?   ?   ?   A . n 
A 1 193 GLY 193 167 ?   ?   ?   A . n 
A 1 194 SER 194 168 168 SER SER A . n 
A 1 195 TYR 195 169 169 TYR TYR A . n 
A 1 196 MET 196 170 170 MET MET A . n 
A 1 197 TRP 197 171 171 TRP TRP A . n 
A 1 198 ILE 198 172 172 ILE ILE A . n 
A 1 199 TYR 199 173 173 TYR TYR A . n 
A 1 200 VAL 200 174 174 VAL VAL A . n 
A 1 201 PHE 201 175 175 PHE PHE A . n 
A 1 202 MET 202 176 176 MET MET A . n 
A 1 203 GLY 203 177 177 GLY GLY A . n 
A 1 204 ASN 204 178 178 ASN ASN A . n 
A 1 205 MET 205 179 179 MET MET A . n 
A 1 206 LEU 206 180 180 LEU LEU A . n 
A 1 207 ARG 207 181 181 ARG ARG A . n 
A 1 208 GLY 208 182 182 GLY GLY A . n 
A 1 209 ILE 209 183 183 ILE ILE A . n 
A 1 210 GLY 210 184 184 GLY GLY A . n 
A 1 211 GLU 211 185 185 GLU GLU A . n 
A 1 212 THR 212 186 186 THR THR A . n 
A 1 213 PRO 213 187 187 PRO PRO A . n 
A 1 214 ILE 214 188 188 ILE ILE A . n 
A 1 215 VAL 215 189 189 VAL VAL A . n 
A 1 216 PRO 216 190 190 PRO PRO A . n 
A 1 217 LEU 217 191 191 LEU LEU A . n 
A 1 218 GLY 218 192 192 GLY GLY A . n 
A 1 219 LEU 219 193 193 LEU LEU A . n 
A 1 220 SER 220 194 194 SER SER A . n 
A 1 221 TYR 221 195 195 TYR TYR A . n 
A 1 222 ILE 222 196 196 ILE ILE A . n 
A 1 223 ASP 223 197 197 ASP ASP A . n 
A 1 224 ASP 224 198 198 ASP ASP A . n 
A 1 225 PHE 225 199 199 PHE PHE A . n 
A 1 226 ALA 226 200 200 ALA ALA A . n 
A 1 227 LYS 227 201 201 LYS LYS A . n 
A 1 228 GLU 228 202 202 GLU GLU A . n 
A 1 229 GLY 229 203 203 GLY GLY A . n 
A 1 230 HIS 230 204 204 HIS HIS A . n 
A 1 231 SER 231 205 205 SER SER A . n 
A 1 232 SER 232 206 206 SER SER A . n 
A 1 233 LEU 233 207 207 LEU LEU A . n 
A 1 234 TYR 234 208 208 TYR TYR A . n 
A 1 235 LEU 235 209 209 LEU LEU A . n 
A 1 236 GLY 236 210 210 GLY GLY A . n 
A 1 237 ILE 237 211 211 ILE ILE A . n 
A 1 238 LEU 238 212 212 LEU LEU A . n 
A 1 239 ASN 239 213 213 ASN ASN A . n 
A 1 240 ALA 240 214 214 ALA ALA A . n 
A 1 241 ILE 241 215 215 ILE ILE A . n 
A 1 242 ALA 242 216 216 ALA ALA A . n 
A 1 243 MET 243 217 217 MET MET A . n 
A 1 244 ILE 244 218 218 ILE ILE A . n 
A 1 245 GLY 245 219 219 GLY GLY A . n 
A 1 246 PRO 246 220 220 PRO PRO A . n 
A 1 247 ILE 247 221 221 ILE ILE A . n 
A 1 248 ILE 248 222 222 ILE ILE A . n 
A 1 249 GLY 249 223 223 GLY GLY A . n 
A 1 250 PHE 250 224 224 PHE PHE A . n 
A 1 251 THR 251 225 225 THR THR A . n 
A 1 252 LEU 252 226 226 LEU LEU A . n 
A 1 253 GLY 253 227 227 GLY GLY A . n 
A 1 254 SER 254 228 228 SER SER A . n 
A 1 255 LEU 255 229 229 LEU LEU A . n 
A 1 256 PHE 256 230 230 PHE PHE A . n 
A 1 257 SER 257 231 231 SER SER A . n 
A 1 258 LYS 258 232 232 LYS LYS A . n 
A 1 259 MET 259 233 233 MET MET A . n 
A 1 260 TYR 260 234 234 TYR TYR A . n 
A 1 261 VAL 261 235 235 VAL VAL A . n 
A 1 262 ASP 262 236 236 ASP ASP A . n 
A 1 263 ILE 263 237 237 ILE ILE A . n 
A 1 264 GLY 264 238 238 GLY GLY A . n 
A 1 265 TYR 265 239 239 TYR TYR A . n 
A 1 266 VAL 266 240 240 VAL VAL A . n 
A 1 267 ASP 267 241 241 ASP ASP A . n 
A 1 268 LEU 268 242 242 LEU LEU A . n 
A 1 269 SER 269 243 243 SER SER A . n 
A 1 270 THR 270 244 244 THR THR A . n 
A 1 271 ILE 271 245 245 ILE ILE A . n 
A 1 272 ARG 272 246 246 ARG ARG A . n 
A 1 273 ILE 273 247 247 ILE ILE A . n 
A 1 274 THR 274 248 248 THR THR A . n 
A 1 275 PRO 275 249 249 PRO PRO A . n 
A 1 276 THR 276 250 250 THR THR A . n 
A 1 277 ASP 277 251 251 ASP ASP A . n 
A 1 278 SER 278 252 252 SER SER A . n 
A 1 279 ARG 279 253 253 ARG ARG A . n 
A 1 280 TRP 280 254 254 TRP TRP A . n 
A 1 281 VAL 281 255 255 VAL VAL A . n 
A 1 282 GLY 282 256 256 GLY GLY A . n 
A 1 283 ALA 283 257 257 ALA ALA A . n 
A 1 284 TRP 284 258 258 TRP TRP A . n 
A 1 285 TRP 285 259 259 TRP TRP A . n 
A 1 286 LEU 286 260 260 LEU LEU A . n 
A 1 287 ASN 287 261 261 ASN ASN A . n 
A 1 288 PHE 288 262 262 PHE PHE A . n 
A 1 289 LEU 289 263 263 LEU LEU A . n 
A 1 290 VAL 290 264 264 VAL VAL A . n 
A 1 291 SER 291 265 265 SER SER A . n 
A 1 292 GLY 292 266 266 GLY GLY A . n 
A 1 293 LEU 293 267 267 LEU LEU A . n 
A 1 294 PHE 294 268 268 PHE PHE A . n 
A 1 295 SER 295 269 269 SER SER A . n 
A 1 296 ILE 296 270 270 ILE ILE A . n 
A 1 297 ILE 297 271 271 ILE ILE A . n 
A 1 298 SER 298 272 272 SER SER A . n 
A 1 299 SER 299 273 273 SER SER A . n 
A 1 300 ILE 300 274 274 ILE ILE A . n 
A 1 301 PRO 301 275 275 PRO PRO A . n 
A 1 302 PHE 302 276 276 PHE PHE A . n 
A 1 303 PHE 303 277 277 PHE PHE A . n 
A 1 304 PHE 304 278 278 PHE PHE A . n 
A 1 305 LEU 305 279 279 LEU LEU A . n 
A 1 306 PRO 306 280 280 PRO PRO A . n 
A 1 307 GLN 307 281 281 GLN GLN A . n 
A 1 308 THR 308 282 282 THR THR A . n 
A 1 309 PRO 309 283 283 PRO PRO A . n 
A 1 310 ASN 310 284 284 ASN ASN A . n 
A 1 311 LYS 311 285 ?   ?   ?   A . n 
A 1 312 PRO 312 286 ?   ?   ?   A . n 
A 1 313 GLN 313 287 ?   ?   ?   A . n 
A 1 314 LYS 314 288 ?   ?   ?   A . n 
A 1 315 GLU 315 289 ?   ?   ?   A . n 
A 1 316 ARG 316 290 ?   ?   ?   A . n 
A 1 317 LYS 317 291 ?   ?   ?   A . n 
A 1 318 ALA 318 292 ?   ?   ?   A . n 
A 1 319 SER 319 293 ?   ?   ?   A . n 
A 1 320 LEU 320 294 ?   ?   ?   A . n 
A 1 321 SER 321 295 ?   ?   ?   A . n 
A 1 322 LEU 322 296 ?   ?   ?   A . n 
A 1 323 HIS 323 297 ?   ?   ?   A . n 
A 1 324 VAL 324 298 ?   ?   ?   A . n 
A 1 325 LEU 325 299 ?   ?   ?   A . n 
A 1 326 GLU 326 300 ?   ?   ?   A . n 
A 1 327 THR 327 301 ?   ?   ?   A . n 
A 1 328 ASN 328 302 ?   ?   ?   A . n 
A 1 329 ASP 329 303 ?   ?   ?   A . n 
A 1 330 GLU 330 304 ?   ?   ?   A . n 
A 1 331 LYS 331 305 ?   ?   ?   A . n 
A 1 332 ASP 332 306 ?   ?   ?   A . n 
A 1 333 GLN 333 307 ?   ?   ?   A . n 
A 1 334 THR 334 308 ?   ?   ?   A . n 
A 1 335 ALA 335 309 ?   ?   ?   A . n 
A 1 336 ASN 336 310 ?   ?   ?   A . n 
A 1 337 LEU 337 311 ?   ?   ?   A . n 
A 1 338 THR 338 312 ?   ?   ?   A . n 
A 1 339 ASN 339 313 ?   ?   ?   A . n 
A 1 340 GLN 340 314 ?   ?   ?   A . n 
A 1 341 GLY 341 315 ?   ?   ?   A . n 
A 1 342 LYS 342 316 ?   ?   ?   A . n 
A 1 343 ASN 343 317 ?   ?   ?   A . n 
A 1 344 ILE 344 318 ?   ?   ?   A . n 
A 1 345 THR 345 319 ?   ?   ?   A . n 
A 1 346 LYS 346 320 ?   ?   ?   A . n 
A 1 347 ASN 347 321 ?   ?   ?   A . n 
A 1 348 VAL 348 322 ?   ?   ?   A . n 
A 1 349 THR 349 323 ?   ?   ?   A . n 
A 1 350 GLY 350 324 324 GLY GLY A . n 
A 1 351 PHE 351 325 325 PHE PHE A . n 
A 1 352 PHE 352 326 326 PHE PHE A . n 
A 1 353 GLN 353 327 327 GLN GLN A . n 
A 1 354 SER 354 328 328 SER SER A . n 
A 1 355 PHE 355 329 329 PHE PHE A . n 
A 1 356 LYS 356 330 330 LYS LYS A . n 
A 1 357 SER 357 331 331 SER SER A . n 
A 1 358 ILE 358 332 332 ILE ILE A . n 
A 1 359 LEU 359 333 333 LEU LEU A . n 
A 1 360 THR 360 334 334 THR THR A . n 
A 1 361 ASN 361 335 335 ASN ASN A . n 
A 1 362 PRO 362 336 336 PRO PRO A . n 
A 1 363 LEU 363 337 337 LEU LEU A . n 
A 1 364 TYR 364 338 338 TYR TYR A . n 
A 1 365 VAL 365 339 339 VAL VAL A . n 
A 1 366 MET 366 340 340 MET MET A . n 
A 1 367 PHE 367 341 341 PHE PHE A . n 
A 1 368 VAL 368 342 342 VAL VAL A . n 
A 1 369 LEU 369 343 343 LEU LEU A . n 
A 1 370 LEU 370 344 344 LEU LEU A . n 
A 1 371 THR 371 345 345 THR THR A . n 
A 1 372 LEU 372 346 346 LEU LEU A . n 
A 1 373 LEU 373 347 347 LEU LEU A . n 
A 1 374 GLN 374 348 348 GLN GLN A . n 
A 1 375 VAL 375 349 349 VAL VAL A . n 
A 1 376 SER 376 350 350 SER SER A . n 
A 1 377 SER 377 351 351 SER SER A . n 
A 1 378 TYR 378 352 352 TYR TYR A . n 
A 1 379 ILE 379 353 353 ILE ILE A . n 
A 1 380 GLY 380 354 354 GLY GLY A . n 
A 1 381 ALA 381 355 355 ALA ALA A . n 
A 1 382 PHE 382 356 356 PHE PHE A . n 
A 1 383 THR 383 357 357 THR THR A . n 
A 1 384 TYR 384 358 358 TYR TYR A . n 
A 1 385 VAL 385 359 359 VAL VAL A . n 
A 1 386 PHE 386 360 360 PHE PHE A . n 
A 1 387 LYS 387 361 361 LYS LYS A . n 
A 1 388 TYR 388 362 362 TYR TYR A . n 
A 1 389 VAL 389 363 363 VAL VAL A . n 
A 1 390 GLU 390 364 364 GLU GLU A . n 
A 1 391 GLN 391 365 365 GLN GLN A . n 
A 1 392 GLN 392 366 366 GLN GLN A . n 
A 1 393 TYR 393 367 367 TYR TYR A . n 
A 1 394 GLY 394 368 368 GLY GLY A . n 
A 1 395 GLN 395 369 369 GLN GLN A . n 
A 1 396 PRO 396 370 370 PRO PRO A . n 
A 1 397 SER 397 371 371 SER SER A . n 
A 1 398 SER 398 372 ?   ?   ?   A . n 
A 1 399 LYS 399 373 ?   ?   ?   A . n 
A 1 400 ALA 400 374 ?   ?   ?   A . n 
A 1 401 ASN 401 375 ?   ?   ?   A . n 
A 1 402 ILE 402 376 ?   ?   ?   A . n 
A 1 403 LEU 403 377 ?   ?   ?   A . n 
A 1 404 LEU 404 378 ?   ?   ?   A . n 
A 1 405 GLY 405 379 379 GLY GLY A . n 
A 1 406 VAL 406 380 380 VAL VAL A . n 
A 1 407 ILE 407 381 381 ILE ILE A . n 
A 1 408 THR 408 382 382 THR THR A . n 
A 1 409 ILE 409 383 383 ILE ILE A . n 
A 1 410 PRO 410 384 384 PRO PRO A . n 
A 1 411 ILE 411 385 385 ILE ILE A . n 
A 1 412 PHE 412 386 386 PHE PHE A . n 
A 1 413 ALA 413 387 387 ALA ALA A . n 
A 1 414 SER 414 388 388 SER SER A . n 
A 1 415 GLY 415 389 389 GLY GLY A . n 
A 1 416 MET 416 390 390 MET MET A . n 
A 1 417 PHE 417 391 391 PHE PHE A . n 
A 1 418 LEU 418 392 392 LEU LEU A . n 
A 1 419 GLY 419 393 393 GLY GLY A . n 
A 1 420 GLY 420 394 394 GLY GLY A . n 
A 1 421 TYR 421 395 395 TYR TYR A . n 
A 1 422 ILE 422 396 396 ILE ILE A . n 
A 1 423 ILE 423 397 397 ILE ILE A . n 
A 1 424 LYS 424 398 398 LYS LYS A . n 
A 1 425 LYS 425 399 399 LYS LYS A . n 
A 1 426 PHE 426 400 400 PHE PHE A . n 
A 1 427 LYS 427 401 401 LYS LYS A . n 
A 1 428 LEU 428 402 402 LEU LEU A . n 
A 1 429 ASN 429 403 403 ASN ASN A . n 
A 1 430 THR 430 404 404 THR THR A . n 
A 1 431 VAL 431 405 405 VAL VAL A . n 
A 1 432 GLY 432 406 406 GLY GLY A . n 
A 1 433 ILE 433 407 407 ILE ILE A . n 
A 1 434 ALA 434 408 408 ALA ALA A . n 
A 1 435 LYS 435 409 409 LYS LYS A . n 
A 1 436 PHE 436 410 410 PHE PHE A . n 
A 1 437 SER 437 411 411 SER SER A . n 
A 1 438 CYS 438 412 412 CYS CYS A . n 
A 1 439 PHE 439 413 413 PHE PHE A . n 
A 1 440 THR 440 414 414 THR THR A . n 
A 1 441 ALA 441 415 415 ALA ALA A . n 
A 1 442 VAL 442 416 416 VAL VAL A . n 
A 1 443 MET 443 417 417 MET MET A . n 
A 1 444 SER 444 418 418 SER SER A . n 
A 1 445 LEU 445 419 419 LEU LEU A . n 
A 1 446 SER 446 420 420 SER SER A . n 
A 1 447 PHE 447 421 421 PHE PHE A . n 
A 1 448 TYR 448 422 422 TYR TYR A . n 
A 1 449 LEU 449 423 423 LEU LEU A . n 
A 1 450 LEU 450 424 424 LEU LEU A . n 
A 1 451 TYR 451 425 425 TYR TYR A . n 
A 1 452 PHE 452 426 426 PHE PHE A . n 
A 1 453 PHE 453 427 427 PHE PHE A . n 
A 1 454 ILE 454 428 428 ILE ILE A . n 
A 1 455 LEU 455 429 429 LEU LEU A . n 
A 1 456 CYS 456 430 430 CYS CYS A . n 
A 1 457 GLU 457 431 431 GLU GLU A . n 
A 1 458 ASN 458 432 432 ASN ASN A . n 
A 1 459 LYS 459 433 433 LYS LYS A . n 
A 1 460 SER 460 434 434 SER SER A . n 
A 1 461 VAL 461 435 435 VAL VAL A . n 
A 1 462 ALA 462 436 436 ALA ALA A . n 
A 1 463 GLY 463 437 437 GLY GLY A . n 
A 1 464 LEU 464 438 438 LEU LEU A . n 
A 1 465 THR 465 439 439 THR THR A . n 
A 1 466 MET 466 440 440 MET MET A . n 
A 1 467 THR 467 441 441 THR THR A . n 
A 1 468 TYR 468 442 442 TYR TYR A . n 
A 1 469 ASP 469 443 443 ASP ASP A . n 
A 1 470 GLY 470 444 444 GLY GLY A . n 
A 1 471 ASN 471 445 445 ASN ASN A . n 
A 1 472 ASN 472 446 446 ASN ASN A . n 
A 1 473 PRO 473 447 447 PRO PRO A . n 
A 1 474 VAL 474 448 448 VAL VAL A . n 
A 1 475 THR 475 449 449 THR THR A . n 
A 1 476 SER 476 450 450 SER SER A . n 
A 1 477 HIS 477 451 451 HIS HIS A . n 
A 1 478 ARG 478 452 452 ARG ARG A . n 
A 1 479 ASP 479 453 453 ASP ASP A . n 
A 1 480 VAL 480 454 454 VAL VAL A . n 
A 1 481 PRO 481 455 455 PRO PRO A . n 
A 1 482 LEU 482 456 456 LEU LEU A . n 
A 1 483 SER 483 457 457 SER SER A . n 
A 1 484 TYR 484 458 458 TYR TYR A . n 
A 1 485 CYS 485 459 459 CYS CYS A . n 
A 1 486 ASN 486 460 460 ASN ASN A . n 
A 1 487 SER 487 461 461 SER SER A . n 
A 1 488 ASP 488 462 462 ASP ASP A . n 
A 1 489 CYS 489 463 463 CYS CYS A . n 
A 1 490 ASN 490 464 464 ASN ASN A . n 
A 1 491 CYS 491 465 465 CYS CYS A . n 
A 1 492 ASP 492 466 466 ASP ASP A . n 
A 1 493 GLU 493 467 467 GLU GLU A . n 
A 1 494 SER 494 468 468 SER SER A . n 
A 1 495 GLN 495 469 469 GLN GLN A . n 
A 1 496 TRP 496 470 470 TRP TRP A . n 
A 1 497 GLU 497 471 471 GLU GLU A . n 
A 1 498 PRO 498 472 472 PRO PRO A . n 
A 1 499 VAL 499 473 473 VAL VAL A . n 
A 1 500 CYS 500 474 474 CYS CYS A . n 
A 1 501 GLY 501 475 475 GLY GLY A . n 
A 1 502 ASN 502 476 476 ASN ASN A . n 
A 1 503 ASN 503 477 477 ASN ASN A . n 
A 1 504 GLY 504 478 478 GLY GLY A . n 
A 1 505 ILE 505 479 479 ILE ILE A . n 
A 1 506 THR 506 480 480 THR THR A . n 
A 1 507 TYR 507 481 481 TYR TYR A . n 
A 1 508 ILE 508 482 482 ILE ILE A . n 
A 1 509 SER 509 483 483 SER SER A . n 
A 1 510 PRO 510 484 484 PRO PRO A . n 
A 1 511 CYS 511 485 485 CYS CYS A . n 
A 1 512 LEU 512 486 486 LEU LEU A . n 
A 1 513 ALA 513 487 487 ALA ALA A . n 
A 1 514 GLY 514 488 488 GLY GLY A . n 
A 1 515 CYS 515 489 489 CYS CYS A . n 
A 1 516 LYS 516 490 490 LYS LYS A . n 
A 1 517 SER 517 491 491 SER SER A . n 
A 1 518 SER 518 492 492 SER SER A . n 
A 1 519 SER 519 493 ?   ?   ?   A . n 
A 1 520 GLY 520 494 ?   ?   ?   A . n 
A 1 521 ASN 521 495 ?   ?   ?   A . n 
A 1 522 LYS 522 496 ?   ?   ?   A . n 
A 1 523 LYS 523 497 ?   ?   ?   A . n 
A 1 524 PRO 524 498 ?   ?   ?   A . n 
A 1 525 ILE 525 499 ?   ?   ?   A . n 
A 1 526 VAL 526 500 ?   ?   ?   A . n 
A 1 527 PHE 527 501 501 PHE PHE A . n 
A 1 528 TYR 528 502 502 TYR TYR A . n 
A 1 529 ASN 529 503 503 ASN ASN A . n 
A 1 530 CYS 530 504 504 CYS CYS A . n 
A 1 531 SER 531 505 505 SER SER A . n 
A 1 532 CYS 532 506 506 CYS CYS A . n 
A 1 533 LEU 533 507 507 LEU LEU A . n 
A 1 534 GLU 534 508 508 GLU GLU A . n 
A 1 535 VAL 535 509 509 VAL VAL A . n 
A 1 536 THR 536 510 ?   ?   ?   A . n 
A 1 537 GLY 537 511 ?   ?   ?   A . n 
A 1 538 LEU 538 512 ?   ?   ?   A . n 
A 1 539 GLN 539 513 ?   ?   ?   A . n 
A 1 540 ASN 540 514 ?   ?   ?   A . n 
A 1 541 ARG 541 515 ?   ?   ?   A . n 
A 1 542 ASN 542 516 ?   ?   ?   A . n 
A 1 543 TYR 543 517 ?   ?   ?   A . n 
A 1 544 SER 544 518 ?   ?   ?   A . n 
A 1 545 ALA 545 519 519 ALA ALA A . n 
A 1 546 HIS 546 520 520 HIS HIS A . n 
A 1 547 LEU 547 521 521 LEU LEU A . n 
A 1 548 GLY 548 522 522 GLY GLY A . n 
A 1 549 GLU 549 523 523 GLU GLU A . n 
A 1 550 CYS 550 524 524 CYS CYS A . n 
A 1 551 PRO 551 525 525 PRO PRO A . n 
A 1 552 ARG 552 526 526 ARG ARG A . n 
A 1 553 ASP 553 527 527 ASP ASP A . n 
A 1 554 ASP 554 528 528 ASP ASP A . n 
A 1 555 ALA 555 529 529 ALA ALA A . n 
A 1 556 CYS 556 530 530 CYS CYS A . n 
A 1 557 THR 557 531 531 THR THR A . n 
A 1 558 ARG 558 532 532 ARG ARG A . n 
A 1 559 LYS 559 533 533 LYS LYS A . n 
A 1 560 PHE 560 534 534 PHE PHE A . n 
A 1 561 TYR 561 535 535 TYR TYR A . n 
A 1 562 PHE 562 536 536 PHE PHE A . n 
A 1 563 PHE 563 537 537 PHE PHE A . n 
A 1 564 VAL 564 538 538 VAL VAL A . n 
A 1 565 ALA 565 539 539 ALA ALA A . n 
A 1 566 ILE 566 540 540 ILE ILE A . n 
A 1 567 GLN 567 541 541 GLN GLN A . n 
A 1 568 VAL 568 542 542 VAL VAL A . n 
A 1 569 LEU 569 543 543 LEU LEU A . n 
A 1 570 ASN 570 544 544 ASN ASN A . n 
A 1 571 LEU 571 545 545 LEU LEU A . n 
A 1 572 PHE 572 546 546 PHE PHE A . n 
A 1 573 PHE 573 547 547 PHE PHE A . n 
A 1 574 SER 574 548 548 SER SER A . n 
A 1 575 ALA 575 549 549 ALA ALA A . n 
A 1 576 LEU 576 550 550 LEU LEU A . n 
A 1 577 GLY 577 551 551 GLY GLY A . n 
A 1 578 GLY 578 552 552 GLY GLY A . n 
A 1 579 THR 579 553 553 THR THR A . n 
A 1 580 SER 580 554 554 SER SER A . n 
A 1 581 HIS 581 555 555 HIS HIS A . n 
A 1 582 VAL 582 556 556 VAL VAL A . n 
A 1 583 MET 583 557 557 MET MET A . n 
A 1 584 LEU 584 558 558 LEU LEU A . n 
A 1 585 ILE 585 559 559 ILE ILE A . n 
A 1 586 VAL 586 560 560 VAL VAL A . n 
A 1 587 LYS 587 561 561 LYS LYS A . n 
A 1 588 ILE 588 562 562 ILE ILE A . n 
A 1 589 VAL 589 563 563 VAL VAL A . n 
A 1 590 GLN 590 564 564 GLN GLN A . n 
A 1 591 PRO 591 565 565 PRO PRO A . n 
A 1 592 GLU 592 566 566 GLU GLU A . n 
A 1 593 LEU 593 567 567 LEU LEU A . n 
A 1 594 LYS 594 568 568 LYS LYS A . n 
A 1 595 SER 595 569 569 SER SER A . n 
A 1 596 LEU 596 570 570 LEU LEU A . n 
A 1 597 ALA 597 571 571 ALA ALA A . n 
A 1 598 LEU 598 572 572 LEU LEU A . n 
A 1 599 GLY 599 573 573 GLY GLY A . n 
A 1 600 PHE 600 574 574 PHE PHE A . n 
A 1 601 HIS 601 575 575 HIS HIS A . n 
A 1 602 SER 602 576 576 SER SER A . n 
A 1 603 MET 603 577 577 MET MET A . n 
A 1 604 VAL 604 578 578 VAL VAL A . n 
A 1 605 ILE 605 579 579 ILE ILE A . n 
A 1 606 ARG 606 580 580 ARG ARG A . n 
A 1 607 ALA 607 581 581 ALA ALA A . n 
A 1 608 LEU 608 582 582 LEU LEU A . n 
A 1 609 GLY 609 583 583 GLY GLY A . n 
A 1 610 GLY 610 584 584 GLY GLY A . n 
A 1 611 ILE 611 585 585 ILE ILE A . n 
A 1 612 LEU 612 586 586 LEU LEU A . n 
A 1 613 ALA 613 587 587 ALA ALA A . n 
A 1 614 PRO 614 588 588 PRO PRO A . n 
A 1 615 ILE 615 589 589 ILE ILE A . n 
A 1 616 TYR 616 590 590 TYR TYR A . n 
A 1 617 PHE 617 591 591 PHE PHE A . n 
A 1 618 GLY 618 592 592 GLY GLY A . n 
A 1 619 ALA 619 593 593 ALA ALA A . n 
A 1 620 LEU 620 594 594 LEU LEU A . n 
A 1 621 ILE 621 595 595 ILE ILE A . n 
A 1 622 ASP 622 596 596 ASP ASP A . n 
A 1 623 THR 623 597 597 THR THR A . n 
A 1 624 THR 624 598 598 THR THR A . n 
A 1 625 CYS 625 599 599 CYS CYS A . n 
A 1 626 ILE 626 600 600 ILE ILE A . n 
A 1 627 LYS 627 601 601 LYS LYS A . n 
A 1 628 TRP 628 602 602 TRP TRP A . n 
A 1 629 SER 629 603 603 SER SER A . n 
A 1 630 THR 630 604 604 THR THR A . n 
A 1 631 ASN 631 605 605 ASN ASN A . n 
A 1 632 ASN 632 606 606 ASN ASN A . n 
A 1 633 CYS 633 607 607 CYS CYS A . n 
A 1 634 GLY 634 608 608 GLY GLY A . n 
A 1 635 THR 635 609 609 THR THR A . n 
A 1 636 ARG 636 610 610 ARG ARG A . n 
A 1 637 GLY 637 611 611 GLY GLY A . n 
A 1 638 SER 638 612 612 SER SER A . n 
A 1 639 CYS 639 613 613 CYS CYS A . n 
A 1 640 ARG 640 614 614 ARG ARG A . n 
A 1 641 THR 641 615 615 THR THR A . n 
A 1 642 TYR 642 616 616 TYR TYR A . n 
A 1 643 ASN 643 617 617 ASN ASN A . n 
A 1 644 SER 644 618 618 SER SER A . n 
A 1 645 THR 645 619 619 THR THR A . n 
A 1 646 SER 646 620 620 SER SER A . n 
A 1 647 PHE 647 621 621 PHE PHE A . n 
A 1 648 SER 648 622 622 SER SER A . n 
A 1 649 ARG 649 623 623 ARG ARG A . n 
A 1 650 VAL 650 624 624 VAL VAL A . n 
A 1 651 TYR 651 625 625 TYR TYR A . n 
A 1 652 LEU 652 626 626 LEU LEU A . n 
A 1 653 GLY 653 627 627 GLY GLY A . n 
A 1 654 LEU 654 628 628 LEU LEU A . n 
A 1 655 SER 655 629 629 SER SER A . n 
A 1 656 SER 656 630 630 SER SER A . n 
A 1 657 MET 657 631 631 MET MET A . n 
A 1 658 LEU 658 632 632 LEU LEU A . n 
A 1 659 ARG 659 633 633 ARG ARG A . n 
A 1 660 VAL 660 634 634 VAL VAL A . n 
A 1 661 SER 661 635 635 SER SER A . n 
A 1 662 SER 662 636 636 SER SER A . n 
A 1 663 LEU 663 637 637 LEU LEU A . n 
A 1 664 VAL 664 638 638 VAL VAL A . n 
A 1 665 LEU 665 639 639 LEU LEU A . n 
A 1 666 TYR 666 640 640 TYR TYR A . n 
A 1 667 ILE 667 641 641 ILE ILE A . n 
A 1 668 ILE 668 642 642 ILE ILE A . n 
A 1 669 LEU 669 643 643 LEU LEU A . n 
A 1 670 ILE 670 644 644 ILE ILE A . n 
A 1 671 TYR 671 645 645 TYR TYR A . n 
A 1 672 ALA 672 646 646 ALA ALA A . n 
A 1 673 MET 673 647 647 MET MET A . n 
A 1 674 LYS 674 648 648 LYS LYS A . n 
A 1 675 LYS 675 649 649 LYS LYS A . n 
A 1 676 LYS 676 650 650 LYS LYS A . n 
A 1 677 TYR 677 651 651 TYR TYR A . n 
A 1 678 GLN 678 652 ?   ?   ?   A . n 
A 1 679 GLU 679 653 ?   ?   ?   A . n 
A 1 680 LYS 680 654 ?   ?   ?   A . n 
A 1 681 ASP 681 655 ?   ?   ?   A . n 
A 1 682 ILE 682 656 ?   ?   ?   A . n 
A 1 683 ASN 683 657 ?   ?   ?   A . n 
A 1 684 ALA 684 658 ?   ?   ?   A . n 
A 1 685 SER 685 659 ?   ?   ?   A . n 
A 1 686 GLU 686 660 ?   ?   ?   A . n 
A 1 687 ASN 687 661 ?   ?   ?   A . n 
A 1 688 GLY 688 662 ?   ?   ?   A . n 
A 1 689 SER 689 663 ?   ?   ?   A . n 
A 1 690 VAL 690 664 ?   ?   ?   A . n 
A 1 691 MET 691 665 ?   ?   ?   A . n 
A 1 692 ASP 692 666 ?   ?   ?   A . n 
A 1 693 GLU 693 667 ?   ?   ?   A . n 
A 1 694 ALA 694 668 ?   ?   ?   A . n 
A 1 695 ASN 695 669 ?   ?   ?   A . n 
A 1 696 LEU 696 670 ?   ?   ?   A . n 
A 1 697 GLU 697 671 ?   ?   ?   A . n 
A 1 698 SER 698 672 ?   ?   ?   A . n 
A 1 699 LEU 699 673 ?   ?   ?   A . n 
A 1 700 ASN 700 674 ?   ?   ?   A . n 
A 1 701 LYS 701 675 ?   ?   ?   A . n 
A 1 702 ASN 702 676 ?   ?   ?   A . n 
A 1 703 LYS 703 677 ?   ?   ?   A . n 
A 1 704 HIS 704 678 ?   ?   ?   A . n 
A 1 705 PHE 705 679 ?   ?   ?   A . n 
A 1 706 VAL 706 680 ?   ?   ?   A . n 
A 1 707 PRO 707 681 ?   ?   ?   A . n 
A 1 708 SER 708 682 ?   ?   ?   A . n 
A 1 709 ALA 709 683 ?   ?   ?   A . n 
A 1 710 GLY 710 684 ?   ?   ?   A . n 
A 1 711 ALA 711 685 ?   ?   ?   A . n 
A 1 712 ASP 712 686 ?   ?   ?   A . n 
A 1 713 SER 713 687 ?   ?   ?   A . n 
A 1 714 GLU 714 688 ?   ?   ?   A . n 
A 1 715 THR 715 689 ?   ?   ?   A . n 
A 1 716 HIS 716 690 ?   ?   ?   A . n 
A 1 717 CYS 717 691 ?   ?   ?   A . n 
B 2 1   GLY 1   1   1   GLY GLY B . n 
B 2 2   SER 2   2   2   SER SER B . n 
B 2 3   SER 3   3   3   SER SER B . n 
B 2 4   SER 4   4   4   SER SER B . n 
B 2 5   GLN 5   5   5   GLN GLN B . n 
B 2 6   VAL 6   6   6   VAL VAL B . n 
B 2 7   GLN 7   7   7   GLN GLN B . n 
B 2 8   LEU 8   8   8   LEU LEU B . n 
B 2 9   VAL 9   9   9   VAL VAL B . n 
B 2 10  GLU 10  10  10  GLU GLU B . n 
B 2 11  SER 11  11  11  SER SER B . n 
B 2 12  GLY 12  12  12  GLY GLY B . n 
B 2 13  GLY 13  13  13  GLY GLY B . n 
B 2 14  GLY 14  14  14  GLY GLY B . n 
B 2 15  LEU 15  15  15  LEU LEU B . n 
B 2 16  VAL 16  16  16  VAL VAL B . n 
B 2 17  GLN 17  17  17  GLN GLN B . n 
B 2 18  ALA 18  18  18  ALA ALA B . n 
B 2 19  GLY 19  19  19  GLY GLY B . n 
B 2 20  GLY 20  20  20  GLY GLY B . n 
B 2 21  SER 21  21  21  SER SER B . n 
B 2 22  LEU 22  22  22  LEU LEU B . n 
B 2 23  ARG 23  23  23  ARG ARG B . n 
B 2 24  LEU 24  24  24  LEU LEU B . n 
B 2 25  SER 25  25  25  SER SER B . n 
B 2 26  CYS 26  26  26  CYS CYS B . n 
B 2 27  ALA 27  27  27  ALA ALA B . n 
B 2 28  ALA 28  28  28  ALA ALA B . n 
B 2 29  SER 29  29  29  SER SER B . n 
B 2 30  GLY 30  30  30  GLY GLY B . n 
B 2 31  PHE 31  31  31  PHE PHE B . n 
B 2 32  PRO 32  32  32  PRO PRO B . n 
B 2 33  VAL 33  33  33  VAL VAL B . n 
B 2 34  ASN 34  34  34  ASN ASN B . n 
B 2 35  LEU 35  35  35  LEU LEU B . n 
B 2 36  SER 36  36  36  SER SER B . n 
B 2 37  TYR 37  37  37  TYR TYR B . n 
B 2 38  MET 38  38  38  MET MET B . n 
B 2 39  HIS 39  39  39  HIS HIS B . n 
B 2 40  TRP 40  40  40  TRP TRP B . n 
B 2 41  TYR 41  41  41  TYR TYR B . n 
B 2 42  ARG 42  42  42  ARG ARG B . n 
B 2 43  GLN 43  43  43  GLN GLN B . n 
B 2 44  ALA 44  44  44  ALA ALA B . n 
B 2 45  PRO 45  45  45  PRO PRO B . n 
B 2 46  GLY 46  46  46  GLY GLY B . n 
B 2 47  LYS 47  47  47  LYS LYS B . n 
B 2 48  GLU 48  48  48  GLU GLU B . n 
B 2 49  ARG 49  49  49  ARG ARG B . n 
B 2 50  GLU 50  50  50  GLU GLU B . n 
B 2 51  TRP 51  51  51  TRP TRP B . n 
B 2 52  VAL 52  52  52  VAL VAL B . n 
B 2 53  ALA 53  53  53  ALA ALA B . n 
B 2 54  ALA 54  54  54  ALA ALA B . n 
B 2 55  ILE 55  55  55  ILE ILE B . n 
B 2 56  SER 56  56  56  SER SER B . n 
B 2 57  SER 57  57  57  SER SER B . n 
B 2 58  TRP 58  58  58  TRP TRP B . n 
B 2 59  GLY 59  59  59  GLY GLY B . n 
B 2 60  TRP 60  60  60  TRP TRP B . n 
B 2 61  HIS 61  61  61  HIS HIS B . n 
B 2 62  THR 62  62  62  THR THR B . n 
B 2 63  GLU 63  63  63  GLU GLU B . n 
B 2 64  TYR 64  64  64  TYR TYR B . n 
B 2 65  ALA 65  65  65  ALA ALA B . n 
B 2 66  ASP 66  66  66  ASP ASP B . n 
B 2 67  SER 67  67  67  SER SER B . n 
B 2 68  VAL 68  68  68  VAL VAL B . n 
B 2 69  LYS 69  69  69  LYS LYS B . n 
B 2 70  GLY 70  70  70  GLY GLY B . n 
B 2 71  ARG 71  71  71  ARG ARG B . n 
B 2 72  PHE 72  72  72  PHE PHE B . n 
B 2 73  THR 73  73  73  THR THR B . n 
B 2 74  ILE 74  74  74  ILE ILE B . n 
B 2 75  SER 75  75  75  SER SER B . n 
B 2 76  ARG 76  76  76  ARG ARG B . n 
B 2 77  ASP 77  77  77  ASP ASP B . n 
B 2 78  ASN 78  78  78  ASN ASN B . n 
B 2 79  ALA 79  79  79  ALA ALA B . n 
B 2 80  LYS 80  80  80  LYS LYS B . n 
B 2 81  ASN 81  81  81  ASN ASN B . n 
B 2 82  THR 82  82  82  THR THR B . n 
B 2 83  VAL 83  83  83  VAL VAL B . n 
B 2 84  TYR 84  84  84  TYR TYR B . n 
B 2 85  LEU 85  85  85  LEU LEU B . n 
B 2 86  GLN 86  86  86  GLN GLN B . n 
B 2 87  MET 87  87  87  MET MET B . n 
B 2 88  ASN 88  88  88  ASN ASN B . n 
B 2 89  SER 89  89  89  SER SER B . n 
B 2 90  LEU 90  90  90  LEU LEU B . n 
B 2 91  LYS 91  91  91  LYS LYS B . n 
B 2 92  PRO 92  92  92  PRO PRO B . n 
B 2 93  GLU 93  93  93  GLU GLU B . n 
B 2 94  ASP 94  94  94  ASP ASP B . n 
B 2 95  THR 95  95  95  THR THR B . n 
B 2 96  ALA 96  96  96  ALA ALA B . n 
B 2 97  VAL 97  97  97  VAL VAL B . n 
B 2 98  TYR 98  98  98  TYR TYR B . n 
B 2 99  TYR 99  99  99  TYR TYR B . n 
B 2 100 CYS 100 100 100 CYS CYS B . n 
B 2 101 HIS 101 101 101 HIS HIS B . n 
B 2 102 VAL 102 102 102 VAL VAL B . n 
B 2 103 ARG 103 103 103 ARG ARG B . n 
B 2 104 VAL 104 104 104 VAL VAL B . n 
B 2 105 GLY 105 105 105 GLY GLY B . n 
B 2 106 ARG 106 106 106 ARG ARG B . n 
B 2 107 SER 107 107 107 SER SER B . n 
B 2 108 TYR 108 108 108 TYR TYR B . n 
B 2 109 PHE 109 109 109 PHE PHE B . n 
B 2 110 GLY 110 110 110 GLY GLY B . n 
B 2 111 GLN 111 111 111 GLN GLN B . n 
B 2 112 GLY 112 112 112 GLY GLY B . n 
B 2 113 THR 113 113 113 THR THR B . n 
B 2 114 GLN 114 114 114 GLN GLN B . n 
B 2 115 VAL 115 115 115 VAL VAL B . n 
B 2 116 SER 116 116 116 SER SER B . n 
B 2 117 VAL 117 117 117 VAL VAL B . n 
B 2 118 SER 118 118 118 SER SER B . n 
B 2 119 ALA 119 119 119 ALA ALA B . n 
B 2 120 GLY 120 120 120 GLY GLY B . n 
B 2 121 ARG 121 121 ?   ?   ?   B . n 
B 2 122 ALA 122 122 ?   ?   ?   B . n 
B 2 123 GLY 123 123 ?   ?   ?   B . n 
B 2 124 GLU 124 124 ?   ?   ?   B . n 
B 2 125 GLN 125 125 ?   ?   ?   B . n 
B 2 126 LYS 126 126 ?   ?   ?   B . n 
B 2 127 LEU 127 127 ?   ?   ?   B . n 
B 2 128 ILE 128 128 ?   ?   ?   B . n 
B 2 129 SER 129 129 ?   ?   ?   B . n 
B 2 130 GLU 130 130 ?   ?   ?   B . n 
B 2 131 GLU 131 131 ?   ?   ?   B . n 
B 2 132 ASP 132 132 ?   ?   ?   B . n 
B 2 133 LEU 133 133 ?   ?   ?   B . n 
B 2 134 ASN 134 134 ?   ?   ?   B . n 
B 2 135 SER 135 135 ?   ?   ?   B . n 
B 2 136 ALA 136 136 ?   ?   ?   B . n 
B 2 137 VAL 137 137 ?   ?   ?   B . n 
B 2 138 ASP 138 138 ?   ?   ?   B . n 
B 2 139 HIS 139 139 ?   ?   ?   B . n 
B 2 140 HIS 140 140 ?   ?   ?   B . n 
B 2 141 HIS 141 141 ?   ?   ?   B . n 
B 2 142 HIS 142 142 ?   ?   ?   B . n 
B 2 143 HIS 143 143 ?   ?   ?   B . n 
B 2 144 HIS 144 144 ?   ?   ?   B . n 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A THR 138 ? OG1 ? A THR 164 OG1 
2  1 Y 1 A THR 138 ? CG2 ? A THR 164 CG2 
3  1 Y 1 A LEU 139 ? CG  ? A LEU 165 CG  
4  1 Y 1 A LEU 139 ? CD1 ? A LEU 165 CD1 
5  1 Y 1 A LEU 139 ? CD2 ? A LEU 165 CD2 
6  1 Y 1 A SER 140 ? OG  ? A SER 166 OG  
7  1 Y 1 A THR 141 ? OG1 ? A THR 167 OG1 
8  1 Y 1 A THR 141 ? CG2 ? A THR 167 CG2 
9  1 Y 1 A LEU 143 ? CG  ? A LEU 169 CG  
10 1 Y 1 A LEU 143 ? CD1 ? A LEU 169 CD1 
11 1 Y 1 A LEU 143 ? CD2 ? A LEU 169 CD2 
12 1 Y 1 A ILE 144 ? CG1 ? A ILE 170 CG1 
13 1 Y 1 A ILE 144 ? CG2 ? A ILE 170 CG2 
14 1 Y 1 A ILE 144 ? CD1 ? A ILE 170 CD1 
15 1 Y 1 B VAL 16  ? CG1 ? B VAL 16  CG1 
16 1 Y 1 B VAL 16  ? CG2 ? B VAL 16  CG2 
17 1 Y 1 B GLN 17  ? CG  ? B GLN 17  CG  
18 1 Y 1 B GLN 17  ? CD  ? B GLN 17  CD  
19 1 Y 1 B GLN 17  ? OE1 ? B GLN 17  OE1 
20 1 Y 1 B GLN 17  ? NE2 ? B GLN 17  NE2 
21 1 Y 1 B GLU 48  ? CG  ? B GLU 48  CG  
22 1 Y 1 B GLU 48  ? CD  ? B GLU 48  CD  
23 1 Y 1 B GLU 48  ? OE1 ? B GLU 48  OE1 
24 1 Y 1 B GLU 48  ? OE2 ? B GLU 48  OE2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9CY1 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9CY1 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9CY1 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.entry_id                                 9CY1 
_refine.pdbx_diffrn_id                           ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             ? 
_refine.ls_d_res_high                            . 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.B_iso_mean                               ? 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.details                                  ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.overall_SU_ML                            ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.005 ? 5152 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.874 ? 6973 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 4.843 ? 699  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.054 ? 781  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.008 ? 858  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9CY1 
_struct.title                        'Outward-facing OATP1B1 bound to sybody Sb5' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9CY1 
_struct_keywords.text            'solute carrier, sybody, membrane protein, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP SO1B1_HUMAN Q9Y6L6 ? 1 
;MDQNQHLNKTAEAQPSENKKTRYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLV
IVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSKETNINSSENSTSTLSTCLINQILSLNRASPEIVGK
GCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYV
DLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITK
NVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKF
KLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGIT
YISPCLAGCKSSSGNKKPIVFYNCSCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIV
KIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLY
IILIYAMKKKYQEKDINASENGSVMDEANLESLNKNKHFVPSAGADSETHC
;
1 
2 PDB 9CY1        9CY1   ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9CY1 A 27 ? 717 ? Q9Y6L6 1 ? 691 ? 1 691 
2 2 9CY1 B 1  ? 144 ? 9CY1   1 ? 144 ? 1 144 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9CY1 MET A 1  ? UNP Q9Y6L6 ? ? 'initiating methionine' -25 1  
1 9CY1 HIS A 2  ? UNP Q9Y6L6 ? ? 'expression tag'        -24 2  
1 9CY1 HIS A 3  ? UNP Q9Y6L6 ? ? 'expression tag'        -23 3  
1 9CY1 HIS A 4  ? UNP Q9Y6L6 ? ? 'expression tag'        -22 4  
1 9CY1 HIS A 5  ? UNP Q9Y6L6 ? ? 'expression tag'        -21 5  
1 9CY1 HIS A 6  ? UNP Q9Y6L6 ? ? 'expression tag'        -20 6  
1 9CY1 HIS A 7  ? UNP Q9Y6L6 ? ? 'expression tag'        -19 7  
1 9CY1 HIS A 8  ? UNP Q9Y6L6 ? ? 'expression tag'        -18 8  
1 9CY1 HIS A 9  ? UNP Q9Y6L6 ? ? 'expression tag'        -17 9  
1 9CY1 HIS A 10 ? UNP Q9Y6L6 ? ? 'expression tag'        -16 10 
1 9CY1 HIS A 11 ? UNP Q9Y6L6 ? ? 'expression tag'        -15 11 
1 9CY1 ASP A 12 ? UNP Q9Y6L6 ? ? 'expression tag'        -14 12 
1 9CY1 TYR A 13 ? UNP Q9Y6L6 ? ? 'expression tag'        -13 13 
1 9CY1 LYS A 14 ? UNP Q9Y6L6 ? ? 'expression tag'        -12 14 
1 9CY1 ASP A 15 ? UNP Q9Y6L6 ? ? 'expression tag'        -11 15 
1 9CY1 ASP A 16 ? UNP Q9Y6L6 ? ? 'expression tag'        -10 16 
1 9CY1 ASP A 17 ? UNP Q9Y6L6 ? ? 'expression tag'        -9  17 
1 9CY1 ASP A 18 ? UNP Q9Y6L6 ? ? 'expression tag'        -8  18 
1 9CY1 LYS A 19 ? UNP Q9Y6L6 ? ? 'expression tag'        -7  19 
1 9CY1 GLU A 20 ? UNP Q9Y6L6 ? ? 'expression tag'        -6  20 
1 9CY1 ASN A 21 ? UNP Q9Y6L6 ? ? 'expression tag'        -5  21 
1 9CY1 LEU A 22 ? UNP Q9Y6L6 ? ? 'expression tag'        -4  22 
1 9CY1 TYR A 23 ? UNP Q9Y6L6 ? ? 'expression tag'        -3  23 
1 9CY1 PHE A 24 ? UNP Q9Y6L6 ? ? 'expression tag'        -2  24 
1 9CY1 GLN A 25 ? UNP Q9Y6L6 ? ? 'expression tag'        -1  25 
1 9CY1 GLY A 26 ? UNP Q9Y6L6 ? ? 'expression tag'        0   26 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 52  ? SER A 77  ? GLY A 26  SER A 51  1 ? 26 
HELX_P HELX_P2  AA2 SER A 77  ? GLU A 86  ? SER A 51  GLU A 60  1 ? 10 
HELX_P HELX_P3  AA3 SER A 88  ? GLY A 114 ? SER A 62  GLY A 88  1 ? 27 
HELX_P HELX_P4  AA4 HIS A 118 ? PHE A 143 ? HIS A 92  PHE A 117 1 ? 26 
HELX_P HELX_P5  AA5 MET A 196 ? GLU A 211 ? MET A 170 GLU A 185 1 ? 16 
HELX_P HELX_P6  AA6 ILE A 214 ? ALA A 226 ? ILE A 188 ALA A 200 1 ? 13 
HELX_P HELX_P7  AA7 HIS A 230 ? ALA A 242 ? HIS A 204 ALA A 216 1 ? 13 
HELX_P HELX_P8  AA8 MET A 243 ? LYS A 258 ? MET A 217 LYS A 232 1 ? 16 
HELX_P HELX_P9  AA9 ALA A 283 ? ILE A 300 ? ALA A 257 ILE A 274 1 ? 18 
HELX_P HELX_P10 AB1 PRO A 301 ? LEU A 305 ? PRO A 275 LEU A 279 5 ? 5  
HELX_P HELX_P11 AB2 PHE A 351 ? THR A 360 ? PHE A 325 THR A 334 1 ? 10 
HELX_P HELX_P12 AB3 ASN A 361 ? TYR A 393 ? ASN A 335 TYR A 367 1 ? 33 
HELX_P HELX_P13 AB4 ILE A 407 ? LYS A 427 ? ILE A 381 LYS A 401 1 ? 21 
HELX_P HELX_P14 AB5 ASN A 429 ? LEU A 449 ? ASN A 403 LEU A 423 1 ? 21 
HELX_P HELX_P15 AB6 LEU A 450 ? PHE A 453 ? LEU A 424 PHE A 427 5 ? 4  
HELX_P HELX_P16 AB7 SER A 483 ? SER A 487 ? SER A 457 SER A 461 5 ? 5  
HELX_P HELX_P17 AB8 ASP A 553 ? GLY A 577 ? ASP A 527 GLY A 551 1 ? 25 
HELX_P HELX_P18 AB9 GLY A 577 ? VAL A 589 ? GLY A 551 VAL A 563 1 ? 13 
HELX_P HELX_P19 AC1 GLN A 590 ? GLU A 592 ? GLN A 564 GLU A 566 5 ? 3  
HELX_P HELX_P20 AC2 LEU A 593 ? GLY A 609 ? LEU A 567 GLY A 583 1 ? 17 
HELX_P HELX_P21 AC3 ILE A 611 ? ASP A 622 ? ILE A 585 ASP A 596 1 ? 12 
HELX_P HELX_P22 AC4 ASN A 643 ? TYR A 677 ? ASN A 617 TYR A 651 1 ? 35 
HELX_P HELX_P23 AC5 LYS B 91  ? THR B 95  ? LYS B 91  THR B 95  5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 456 SG ? ? ? 1_555 A CYS 556 SG ? ? A CYS 430 A CYS 530 1_555 ? ? ? ? ? ? ? 2.037 ? ? 
disulf2 disulf ? ? A CYS 485 SG ? ? ? 1_555 A CYS 532 SG ? ? A CYS 459 A CYS 506 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
disulf3 disulf ? ? A CYS 491 SG ? ? ? 1_555 A CYS 511 SG ? ? A CYS 465 A CYS 485 1_555 ? ? ? ? ? ? ? 2.027 ? ? 
disulf4 disulf ? ? A CYS 500 SG ? ? ? 1_555 A CYS 550 SG ? ? A CYS 474 A CYS 524 1_555 ? ? ? ? ? ? ? 2.028 ? ? 
disulf5 disulf ? ? A CYS 515 SG ? ? ? 1_555 A CYS 530 SG ? ? A CYS 489 A CYS 504 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
disulf6 disulf ? ? A CYS 625 SG ? ? ? 1_555 A CYS 639 SG ? ? A CYS 599 A CYS 613 1_555 ? ? ? ? ? ? ? 2.027 ? ? 
disulf7 disulf ? ? B CYS 26  SG ? ? ? 1_555 B CYS 100 SG ? ? B CYS 26  B CYS 100 1_555 ? ? ? ? ? ? ? 2.027 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 456 ? CYS A 556 ? CYS A 430 ? 1_555 CYS A 530 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 485 ? CYS A 532 ? CYS A 459 ? 1_555 CYS A 506 ? 1_555 SG SG . . . None 'Disulfide bridge' 
3 CYS A 491 ? CYS A 511 ? CYS A 465 ? 1_555 CYS A 485 ? 1_555 SG SG . . . None 'Disulfide bridge' 
4 CYS A 500 ? CYS A 550 ? CYS A 474 ? 1_555 CYS A 524 ? 1_555 SG SG . . . None 'Disulfide bridge' 
5 CYS A 515 ? CYS A 530 ? CYS A 489 ? 1_555 CYS A 504 ? 1_555 SG SG . . . None 'Disulfide bridge' 
6 CYS A 625 ? CYS A 639 ? CYS A 599 ? 1_555 CYS A 613 ? 1_555 SG SG . . . None 'Disulfide bridge' 
7 CYS B 26  ? CYS B 100 ? CYS B 26  ? 1_555 CYS B 100 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 4 ? 
AA5 ? 2 ? 
AA6 ? 5 ? 
AA7 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? anti-parallel 
AA5 1 2 ? parallel      
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 VAL A 461 ? ALA A 462 ? VAL A 435 ALA A 436 
AA1 2 THR A 506 ? TYR A 507 ? THR A 480 TYR A 481 
AA1 3 VAL A 499 ? CYS A 500 ? VAL A 473 CYS A 474 
AA1 4 HIS A 546 ? LEU A 547 ? HIS A 520 LEU A 521 
AA2 1 CYS A 515 ? SER A 517 ? CYS A 489 SER A 491 
AA2 2 TYR A 528 ? CYS A 530 ? TYR A 502 CYS A 504 
AA3 1 CYS A 625 ? TRP A 628 ? CYS A 599 TRP A 602 
AA3 2 CYS A 639 ? TYR A 642 ? CYS A 613 TYR A 616 
AA4 1 GLN B 7   ? SER B 11  ? GLN B 7   SER B 11  
AA4 2 SER B 21  ? SER B 29  ? SER B 21  SER B 29  
AA4 3 THR B 82  ? ASN B 88  ? THR B 82  ASN B 88  
AA4 4 PHE B 72  ? ASP B 77  ? PHE B 72  ASP B 77  
AA5 1 VAL B 16  ? GLN B 17  ? VAL B 16  GLN B 17  
AA5 2 VAL B 117 ? SER B 118 ? VAL B 117 SER B 118 
AA6 1 THR B 62  ? TYR B 64  ? THR B 62  TYR B 64  
AA6 2 ARG B 49  ? ILE B 55  ? ARG B 49  ILE B 55  
AA6 3 MET B 38  ? GLN B 43  ? MET B 38  GLN B 43  
AA6 4 VAL B 97  ? VAL B 102 ? VAL B 97  VAL B 102 
AA6 5 TYR B 108 ? PHE B 109 ? TYR B 108 PHE B 109 
AA7 1 THR B 62  ? TYR B 64  ? THR B 62  TYR B 64  
AA7 2 ARG B 49  ? ILE B 55  ? ARG B 49  ILE B 55  
AA7 3 MET B 38  ? GLN B 43  ? MET B 38  GLN B 43  
AA7 4 VAL B 97  ? VAL B 102 ? VAL B 97  VAL B 102 
AA7 5 THR B 113 ? GLN B 114 ? THR B 113 GLN B 114 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 462 ? N ALA A 436 O THR A 506 ? O THR A 480 
AA1 2 3 O TYR A 507 ? O TYR A 481 N VAL A 499 ? N VAL A 473 
AA1 3 4 N CYS A 500 ? N CYS A 474 O HIS A 546 ? O HIS A 520 
AA2 1 2 N SER A 517 ? N SER A 491 O TYR A 528 ? O TYR A 502 
AA3 1 2 N ILE A 626 ? N ILE A 600 O THR A 641 ? O THR A 615 
AA4 1 2 N GLN B 7   ? N GLN B 7   O SER B 29  ? O SER B 29  
AA4 2 3 N LEU B 22  ? N LEU B 22  O MET B 87  ? O MET B 87  
AA4 3 4 O GLN B 86  ? O GLN B 86  N THR B 73  ? N THR B 73  
AA5 1 2 N VAL B 16  ? N VAL B 16  O SER B 118 ? O SER B 118 
AA6 1 2 O GLU B 63  ? O GLU B 63  N ALA B 54  ? N ALA B 54  
AA6 2 3 O GLU B 50  ? O GLU B 50  N ARG B 42  ? N ARG B 42  
AA6 3 4 N TYR B 41  ? N TYR B 41  O TYR B 99  ? O TYR B 99  
AA6 4 5 N VAL B 102 ? N VAL B 102 O TYR B 108 ? O TYR B 108 
AA7 1 2 O GLU B 63  ? O GLU B 63  N ALA B 54  ? N ALA B 54  
AA7 2 3 O GLU B 50  ? O GLU B 50  N ARG B 42  ? N ARG B 42  
AA7 3 4 N TYR B 41  ? N TYR B 41  O TYR B 99  ? O TYR B 99  
AA7 4 5 N TYR B 98  ? N TYR B 98  O THR B 113 ? O THR B 113 
# 
_pdbx_entry_details.entry_id                   9CY1 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CB A ASP 197 ? ? CG A ASP 197 ? ? OD1 A ASP 197 ? ? 125.61 118.30 7.31  0.90 N 
2 1 CA A LEU 344 ? ? CB A LEU 344 ? ? CG  A LEU 344 ? ? 131.05 115.30 15.75 2.30 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 236 ? ? -97.22  36.21   
2 1 LEU A 438 ? ? -120.44 -50.38  
3 1 MET A 440 ? ? -128.56 -169.16 
4 1 CYS A 463 ? ? 60.15   64.39   
5 1 ASN A 464 ? ? -92.16  56.05   
6 1 ALA B 18  ? ? 55.56   -151.19 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9CY1 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9CY1 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.15 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               58056 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Outward-facing OATP1B1 bound to sybody 5' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       '1, 2' 
# 
_em_imaging.entry_id                        9CY1 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             600 
_em_imaging.nominal_defocus_max             2200 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9CY1 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9CY1 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -25 ? A MET 1   
2   1 Y 1 A HIS -24 ? A HIS 2   
3   1 Y 1 A HIS -23 ? A HIS 3   
4   1 Y 1 A HIS -22 ? A HIS 4   
5   1 Y 1 A HIS -21 ? A HIS 5   
6   1 Y 1 A HIS -20 ? A HIS 6   
7   1 Y 1 A HIS -19 ? A HIS 7   
8   1 Y 1 A HIS -18 ? A HIS 8   
9   1 Y 1 A HIS -17 ? A HIS 9   
10  1 Y 1 A HIS -16 ? A HIS 10  
11  1 Y 1 A HIS -15 ? A HIS 11  
12  1 Y 1 A ASP -14 ? A ASP 12  
13  1 Y 1 A TYR -13 ? A TYR 13  
14  1 Y 1 A LYS -12 ? A LYS 14  
15  1 Y 1 A ASP -11 ? A ASP 15  
16  1 Y 1 A ASP -10 ? A ASP 16  
17  1 Y 1 A ASP -9  ? A ASP 17  
18  1 Y 1 A ASP -8  ? A ASP 18  
19  1 Y 1 A LYS -7  ? A LYS 19  
20  1 Y 1 A GLU -6  ? A GLU 20  
21  1 Y 1 A ASN -5  ? A ASN 21  
22  1 Y 1 A LEU -4  ? A LEU 22  
23  1 Y 1 A TYR -3  ? A TYR 23  
24  1 Y 1 A PHE -2  ? A PHE 24  
25  1 Y 1 A GLN -1  ? A GLN 25  
26  1 Y 1 A GLY 0   ? A GLY 26  
27  1 Y 1 A MET 1   ? A MET 27  
28  1 Y 1 A ASP 2   ? A ASP 28  
29  1 Y 1 A GLN 3   ? A GLN 29  
30  1 Y 1 A ASN 4   ? A ASN 30  
31  1 Y 1 A GLN 5   ? A GLN 31  
32  1 Y 1 A HIS 6   ? A HIS 32  
33  1 Y 1 A LEU 7   ? A LEU 33  
34  1 Y 1 A ASN 8   ? A ASN 34  
35  1 Y 1 A LYS 9   ? A LYS 35  
36  1 Y 1 A THR 10  ? A THR 36  
37  1 Y 1 A ALA 11  ? A ALA 37  
38  1 Y 1 A GLU 12  ? A GLU 38  
39  1 Y 1 A ALA 13  ? A ALA 39  
40  1 Y 1 A GLN 14  ? A GLN 40  
41  1 Y 1 A PRO 15  ? A PRO 41  
42  1 Y 1 A SER 16  ? A SER 42  
43  1 Y 1 A GLU 17  ? A GLU 43  
44  1 Y 1 A ASN 18  ? A ASN 44  
45  1 Y 1 A LYS 19  ? A LYS 45  
46  1 Y 1 A LYS 20  ? A LYS 46  
47  1 Y 1 A THR 21  ? A THR 47  
48  1 Y 1 A ARG 22  ? A ARG 48  
49  1 Y 1 A TYR 23  ? A TYR 49  
50  1 Y 1 A LYS 125 ? A LYS 151 
51  1 Y 1 A GLU 126 ? A GLU 152 
52  1 Y 1 A THR 127 ? A THR 153 
53  1 Y 1 A ASN 128 ? A ASN 154 
54  1 Y 1 A ILE 129 ? A ILE 155 
55  1 Y 1 A ASN 130 ? A ASN 156 
56  1 Y 1 A SER 131 ? A SER 157 
57  1 Y 1 A SER 132 ? A SER 158 
58  1 Y 1 A GLU 133 ? A GLU 159 
59  1 Y 1 A ASN 134 ? A ASN 160 
60  1 Y 1 A SER 135 ? A SER 161 
61  1 Y 1 A THR 136 ? A THR 162 
62  1 Y 1 A SER 137 ? A SER 163 
63  1 Y 1 A ASN 145 ? A ASN 171 
64  1 Y 1 A GLN 146 ? A GLN 172 
65  1 Y 1 A ILE 147 ? A ILE 173 
66  1 Y 1 A LEU 148 ? A LEU 174 
67  1 Y 1 A SER 149 ? A SER 175 
68  1 Y 1 A LEU 150 ? A LEU 176 
69  1 Y 1 A ASN 151 ? A ASN 177 
70  1 Y 1 A ARG 152 ? A ARG 178 
71  1 Y 1 A ALA 153 ? A ALA 179 
72  1 Y 1 A SER 154 ? A SER 180 
73  1 Y 1 A PRO 155 ? A PRO 181 
74  1 Y 1 A GLU 156 ? A GLU 182 
75  1 Y 1 A ILE 157 ? A ILE 183 
76  1 Y 1 A VAL 158 ? A VAL 184 
77  1 Y 1 A GLY 159 ? A GLY 185 
78  1 Y 1 A LYS 160 ? A LYS 186 
79  1 Y 1 A GLY 161 ? A GLY 187 
80  1 Y 1 A CYS 162 ? A CYS 188 
81  1 Y 1 A LEU 163 ? A LEU 189 
82  1 Y 1 A LYS 164 ? A LYS 190 
83  1 Y 1 A GLU 165 ? A GLU 191 
84  1 Y 1 A SER 166 ? A SER 192 
85  1 Y 1 A GLY 167 ? A GLY 193 
86  1 Y 1 A LYS 285 ? A LYS 311 
87  1 Y 1 A PRO 286 ? A PRO 312 
88  1 Y 1 A GLN 287 ? A GLN 313 
89  1 Y 1 A LYS 288 ? A LYS 314 
90  1 Y 1 A GLU 289 ? A GLU 315 
91  1 Y 1 A ARG 290 ? A ARG 316 
92  1 Y 1 A LYS 291 ? A LYS 317 
93  1 Y 1 A ALA 292 ? A ALA 318 
94  1 Y 1 A SER 293 ? A SER 319 
95  1 Y 1 A LEU 294 ? A LEU 320 
96  1 Y 1 A SER 295 ? A SER 321 
97  1 Y 1 A LEU 296 ? A LEU 322 
98  1 Y 1 A HIS 297 ? A HIS 323 
99  1 Y 1 A VAL 298 ? A VAL 324 
100 1 Y 1 A LEU 299 ? A LEU 325 
101 1 Y 1 A GLU 300 ? A GLU 326 
102 1 Y 1 A THR 301 ? A THR 327 
103 1 Y 1 A ASN 302 ? A ASN 328 
104 1 Y 1 A ASP 303 ? A ASP 329 
105 1 Y 1 A GLU 304 ? A GLU 330 
106 1 Y 1 A LYS 305 ? A LYS 331 
107 1 Y 1 A ASP 306 ? A ASP 332 
108 1 Y 1 A GLN 307 ? A GLN 333 
109 1 Y 1 A THR 308 ? A THR 334 
110 1 Y 1 A ALA 309 ? A ALA 335 
111 1 Y 1 A ASN 310 ? A ASN 336 
112 1 Y 1 A LEU 311 ? A LEU 337 
113 1 Y 1 A THR 312 ? A THR 338 
114 1 Y 1 A ASN 313 ? A ASN 339 
115 1 Y 1 A GLN 314 ? A GLN 340 
116 1 Y 1 A GLY 315 ? A GLY 341 
117 1 Y 1 A LYS 316 ? A LYS 342 
118 1 Y 1 A ASN 317 ? A ASN 343 
119 1 Y 1 A ILE 318 ? A ILE 344 
120 1 Y 1 A THR 319 ? A THR 345 
121 1 Y 1 A LYS 320 ? A LYS 346 
122 1 Y 1 A ASN 321 ? A ASN 347 
123 1 Y 1 A VAL 322 ? A VAL 348 
124 1 Y 1 A THR 323 ? A THR 349 
125 1 Y 1 A SER 372 ? A SER 398 
126 1 Y 1 A LYS 373 ? A LYS 399 
127 1 Y 1 A ALA 374 ? A ALA 400 
128 1 Y 1 A ASN 375 ? A ASN 401 
129 1 Y 1 A ILE 376 ? A ILE 402 
130 1 Y 1 A LEU 377 ? A LEU 403 
131 1 Y 1 A LEU 378 ? A LEU 404 
132 1 Y 1 A SER 493 ? A SER 519 
133 1 Y 1 A GLY 494 ? A GLY 520 
134 1 Y 1 A ASN 495 ? A ASN 521 
135 1 Y 1 A LYS 496 ? A LYS 522 
136 1 Y 1 A LYS 497 ? A LYS 523 
137 1 Y 1 A PRO 498 ? A PRO 524 
138 1 Y 1 A ILE 499 ? A ILE 525 
139 1 Y 1 A VAL 500 ? A VAL 526 
140 1 Y 1 A THR 510 ? A THR 536 
141 1 Y 1 A GLY 511 ? A GLY 537 
142 1 Y 1 A LEU 512 ? A LEU 538 
143 1 Y 1 A GLN 513 ? A GLN 539 
144 1 Y 1 A ASN 514 ? A ASN 540 
145 1 Y 1 A ARG 515 ? A ARG 541 
146 1 Y 1 A ASN 516 ? A ASN 542 
147 1 Y 1 A TYR 517 ? A TYR 543 
148 1 Y 1 A SER 518 ? A SER 544 
149 1 Y 1 A GLN 652 ? A GLN 678 
150 1 Y 1 A GLU 653 ? A GLU 679 
151 1 Y 1 A LYS 654 ? A LYS 680 
152 1 Y 1 A ASP 655 ? A ASP 681 
153 1 Y 1 A ILE 656 ? A ILE 682 
154 1 Y 1 A ASN 657 ? A ASN 683 
155 1 Y 1 A ALA 658 ? A ALA 684 
156 1 Y 1 A SER 659 ? A SER 685 
157 1 Y 1 A GLU 660 ? A GLU 686 
158 1 Y 1 A ASN 661 ? A ASN 687 
159 1 Y 1 A GLY 662 ? A GLY 688 
160 1 Y 1 A SER 663 ? A SER 689 
161 1 Y 1 A VAL 664 ? A VAL 690 
162 1 Y 1 A MET 665 ? A MET 691 
163 1 Y 1 A ASP 666 ? A ASP 692 
164 1 Y 1 A GLU 667 ? A GLU 693 
165 1 Y 1 A ALA 668 ? A ALA 694 
166 1 Y 1 A ASN 669 ? A ASN 695 
167 1 Y 1 A LEU 670 ? A LEU 696 
168 1 Y 1 A GLU 671 ? A GLU 697 
169 1 Y 1 A SER 672 ? A SER 698 
170 1 Y 1 A LEU 673 ? A LEU 699 
171 1 Y 1 A ASN 674 ? A ASN 700 
172 1 Y 1 A LYS 675 ? A LYS 701 
173 1 Y 1 A ASN 676 ? A ASN 702 
174 1 Y 1 A LYS 677 ? A LYS 703 
175 1 Y 1 A HIS 678 ? A HIS 704 
176 1 Y 1 A PHE 679 ? A PHE 705 
177 1 Y 1 A VAL 680 ? A VAL 706 
178 1 Y 1 A PRO 681 ? A PRO 707 
179 1 Y 1 A SER 682 ? A SER 708 
180 1 Y 1 A ALA 683 ? A ALA 709 
181 1 Y 1 A GLY 684 ? A GLY 710 
182 1 Y 1 A ALA 685 ? A ALA 711 
183 1 Y 1 A ASP 686 ? A ASP 712 
184 1 Y 1 A SER 687 ? A SER 713 
185 1 Y 1 A GLU 688 ? A GLU 714 
186 1 Y 1 A THR 689 ? A THR 715 
187 1 Y 1 A HIS 690 ? A HIS 716 
188 1 Y 1 A CYS 691 ? A CYS 717 
189 1 Y 1 B ARG 121 ? B ARG 121 
190 1 Y 1 B ALA 122 ? B ALA 122 
191 1 Y 1 B GLY 123 ? B GLY 123 
192 1 Y 1 B GLU 124 ? B GLU 124 
193 1 Y 1 B GLN 125 ? B GLN 125 
194 1 Y 1 B LYS 126 ? B LYS 126 
195 1 Y 1 B LEU 127 ? B LEU 127 
196 1 Y 1 B ILE 128 ? B ILE 128 
197 1 Y 1 B SER 129 ? B SER 129 
198 1 Y 1 B GLU 130 ? B GLU 130 
199 1 Y 1 B GLU 131 ? B GLU 131 
200 1 Y 1 B ASP 132 ? B ASP 132 
201 1 Y 1 B LEU 133 ? B LEU 133 
202 1 Y 1 B ASN 134 ? B ASN 134 
203 1 Y 1 B SER 135 ? B SER 135 
204 1 Y 1 B ALA 136 ? B ALA 136 
205 1 Y 1 B VAL 137 ? B VAL 137 
206 1 Y 1 B ASP 138 ? B ASP 138 
207 1 Y 1 B HIS 139 ? B HIS 139 
208 1 Y 1 B HIS 140 ? B HIS 140 
209 1 Y 1 B HIS 141 ? B HIS 141 
210 1 Y 1 B HIS 142 ? B HIS 142 
211 1 Y 1 B HIS 143 ? B HIS 143 
212 1 Y 1 B HIS 144 ? B HIS 144 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-08-01 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9CY1 
_em_admin.last_update        2025-05-28 
_em_admin.map_release_date   2025-04-16 
_em_admin.title              'Outward-facing OATP1B1 bound to sybody Sb5' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'TFS FALCON 4i (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?      ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ?      ? 
MASKING                         ? 3  ? ? ? ?      ? 
'CTF CORRECTION'                ? 4  1 ? ? ?      ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ?      ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?      ? 
'MODEL FITTING'                 ? 7  ? ? ? ?      ? 
'MODEL REFINEMENT'              ? 8  ? ? ? PHENIX ? 
OTHER                           ? 9  ? ? ? ?      ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?      ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?      ? 
CLASSIFICATION                  ? 12 1 ? ? ?      ? 
RECONSTRUCTION                  ? 13 1 ? ? ?      ? 
'VOLUME SELECTION'              ? 14 1 1 1 ?      ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ?      ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?      ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?      ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?      ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?      ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9CY1 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . CYS A 1 50  ? 117.156 103.384 130.613 1.00 68.51  ? 24  CYS A N   1 
ATOM 2    C CA  . CYS A 1 50  ? 118.514 103.715 131.025 1.00 68.51  ? 24  CYS A CA  1 
ATOM 3    C C   . CYS A 1 50  ? 119.338 102.449 131.231 1.00 68.51  ? 24  CYS A C   1 
ATOM 4    O O   . CYS A 1 50  ? 119.019 101.621 132.083 1.00 68.51  ? 24  CYS A O   1 
ATOM 5    C CB  . CYS A 1 50  ? 118.496 104.555 132.302 1.00 68.51  ? 24  CYS A CB  1 
ATOM 6    S SG  . CYS A 1 50  ? 117.779 106.200 132.089 1.00 68.51  ? 24  CYS A SG  1 
ATOM 7    N N   . ASN A 1 51  ? 120.403 102.306 130.443 1.00 67.29  ? 25  ASN A N   1 
ATOM 8    C CA  . ASN A 1 51  ? 121.217 101.098 130.468 1.00 67.29  ? 25  ASN A CA  1 
ATOM 9    C C   . ASN A 1 51  ? 122.660 101.410 130.840 1.00 67.29  ? 25  ASN A C   1 
ATOM 10   O O   . ASN A 1 51  ? 123.592 100.931 130.187 1.00 67.29  ? 25  ASN A O   1 
ATOM 11   C CB  . ASN A 1 51  ? 121.161 100.385 129.116 1.00 67.29  ? 25  ASN A CB  1 
ATOM 12   C CG  . ASN A 1 51  ? 119.799 99.782  128.830 1.00 67.29  ? 25  ASN A CG  1 
ATOM 13   O OD1 . ASN A 1 51  ? 118.969 99.640  129.727 1.00 67.29  ? 25  ASN A OD1 1 
ATOM 14   N ND2 . ASN A 1 51  ? 119.563 99.425  127.573 1.00 67.29  ? 25  ASN A ND2 1 
ATOM 15   N N   . GLY A 1 52  ? 122.854 102.216 131.880 1.00 56.47  ? 26  GLY A N   1 
ATOM 16   C CA  . GLY A 1 52  ? 124.186 102.495 132.375 1.00 56.47  ? 26  GLY A CA  1 
ATOM 17   C C   . GLY A 1 52  ? 124.810 103.763 131.833 1.00 56.47  ? 26  GLY A C   1 
ATOM 18   O O   . GLY A 1 52  ? 125.175 104.652 132.606 1.00 56.47  ? 26  GLY A O   1 
ATOM 19   N N   . LEU A 1 53  ? 124.949 103.860 130.509 1.00 48.08  ? 27  LEU A N   1 
ATOM 20   C CA  . LEU A 1 53  ? 125.579 105.042 129.932 1.00 48.08  ? 27  LEU A CA  1 
ATOM 21   C C   . LEU A 1 53  ? 124.632 106.235 129.937 1.00 48.08  ? 27  LEU A C   1 
ATOM 22   O O   . LEU A 1 53  ? 125.089 107.381 129.998 1.00 48.08  ? 27  LEU A O   1 
ATOM 23   C CB  . LEU A 1 53  ? 126.079 104.731 128.517 1.00 48.08  ? 27  LEU A CB  1 
ATOM 24   C CG  . LEU A 1 53  ? 127.020 105.703 127.792 1.00 48.08  ? 27  LEU A CG  1 
ATOM 25   C CD1 . LEU A 1 53  ? 127.931 104.903 126.906 1.00 48.08  ? 27  LEU A CD1 1 
ATOM 26   C CD2 . LEU A 1 53  ? 126.299 106.733 126.939 1.00 48.08  ? 27  LEU A CD2 1 
ATOM 27   N N   . LYS A 1 54  ? 123.321 105.990 129.873 1.00 47.38  ? 28  LYS A N   1 
ATOM 28   C CA  . LYS A 1 54  ? 122.358 107.086 129.903 1.00 47.38  ? 28  LYS A CA  1 
ATOM 29   C C   . LYS A 1 54  ? 122.319 107.750 131.274 1.00 47.38  ? 28  LYS A C   1 
ATOM 30   O O   . LYS A 1 54  ? 122.104 108.965 131.376 1.00 47.38  ? 28  LYS A O   1 
ATOM 31   C CB  . LYS A 1 54  ? 120.974 106.575 129.505 1.00 47.38  ? 28  LYS A CB  1 
ATOM 32   C CG  . LYS A 1 54  ? 120.651 106.729 128.020 1.00 47.38  ? 28  LYS A CG  1 
ATOM 33   C CD  . LYS A 1 54  ? 120.800 108.172 127.556 1.00 47.38  ? 28  LYS A CD  1 
ATOM 34   C CE  . LYS A 1 54  ? 119.803 108.511 126.457 1.00 47.38  ? 28  LYS A CE  1 
ATOM 35   N NZ  . LYS A 1 54  ? 119.845 109.950 126.068 1.00 47.38  ? 28  LYS A NZ  1 
ATOM 36   N N   . MET A 1 55  ? 122.539 106.967 132.337 1.00 47.49  ? 29  MET A N   1 
ATOM 37   C CA  . MET A 1 55  ? 122.659 107.534 133.679 1.00 47.49  ? 29  MET A CA  1 
ATOM 38   C C   . MET A 1 55  ? 123.875 108.442 133.789 1.00 47.49  ? 29  MET A C   1 
ATOM 39   O O   . MET A 1 55  ? 123.796 109.529 134.379 1.00 47.49  ? 29  MET A O   1 
ATOM 40   C CB  . MET A 1 55  ? 122.743 106.417 134.716 1.00 47.49  ? 29  MET A CB  1 
ATOM 41   C CG  . MET A 1 55  ? 121.487 105.587 134.863 1.00 47.49  ? 29  MET A CG  1 
ATOM 42   S SD  . MET A 1 55  ? 121.736 104.254 136.049 1.00 47.49  ? 29  MET A SD  1 
ATOM 43   C CE  . MET A 1 55  ? 121.827 105.178 137.580 1.00 47.49  ? 29  MET A CE  1 
ATOM 44   N N   . PHE A 1 56  ? 125.005 108.016 133.212 1.00 37.46  ? 30  PHE A N   1 
ATOM 45   C CA  . PHE A 1 56  ? 126.194 108.860 133.188 1.00 37.46  ? 30  PHE A CA  1 
ATOM 46   C C   . PHE A 1 56  ? 125.959 110.109 132.355 1.00 37.46  ? 30  PHE A C   1 
ATOM 47   O O   . PHE A 1 56  ? 126.467 111.184 132.685 1.00 37.46  ? 30  PHE A O   1 
ATOM 48   C CB  . PHE A 1 56  ? 127.399 108.087 132.646 1.00 37.46  ? 30  PHE A CB  1 
ATOM 49   C CG  . PHE A 1 56  ? 128.675 108.891 132.632 1.00 37.46  ? 30  PHE A CG  1 
ATOM 50   C CD1 . PHE A 1 56  ? 129.436 109.015 133.781 1.00 37.46  ? 30  PHE A CD1 1 
ATOM 51   C CD2 . PHE A 1 56  ? 129.109 109.533 131.477 1.00 37.46  ? 30  PHE A CD2 1 
ATOM 52   C CE1 . PHE A 1 56  ? 130.600 109.755 133.781 1.00 37.46  ? 30  PHE A CE1 1 
ATOM 53   C CE2 . PHE A 1 56  ? 130.263 110.283 131.479 1.00 37.46  ? 30  PHE A CE2 1 
ATOM 54   C CZ  . PHE A 1 56  ? 131.011 110.386 132.631 1.00 37.46  ? 30  PHE A CZ  1 
ATOM 55   N N   . LEU A 1 57  ? 125.208 109.976 131.261 1.00 38.55  ? 31  LEU A N   1 
ATOM 56   C CA  . LEU A 1 57  ? 124.922 111.116 130.399 1.00 38.55  ? 31  LEU A CA  1 
ATOM 57   C C   . LEU A 1 57  ? 124.074 112.152 131.128 1.00 38.55  ? 31  LEU A C   1 
ATOM 58   O O   . LEU A 1 57  ? 124.338 113.356 131.038 1.00 38.55  ? 31  LEU A O   1 
ATOM 59   C CB  . LEU A 1 57  ? 124.213 110.634 129.135 1.00 38.55  ? 31  LEU A CB  1 
ATOM 60   C CG  . LEU A 1 57  ? 123.900 111.682 128.077 1.00 38.55  ? 31  LEU A CG  1 
ATOM 61   C CD1 . LEU A 1 57  ? 125.195 112.254 127.564 1.00 38.55  ? 31  LEU A CD1 1 
ATOM 62   C CD2 . LEU A 1 57  ? 123.093 111.086 126.955 1.00 38.55  ? 31  LEU A CD2 1 
ATOM 63   N N   . ALA A 1 58  ? 123.079 111.691 131.895 1.00 38.16  ? 32  ALA A N   1 
ATOM 64   C CA  . ALA A 1 58  ? 122.254 112.600 132.687 1.00 38.16  ? 32  ALA A CA  1 
ATOM 65   C C   . ALA A 1 58  ? 123.051 113.257 133.811 1.00 38.16  ? 32  ALA A C   1 
ATOM 66   O O   . ALA A 1 58  ? 122.904 114.461 134.064 1.00 38.16  ? 32  ALA A O   1 
ATOM 67   C CB  . ALA A 1 58  ? 121.052 111.850 133.253 1.00 38.16  ? 32  ALA A CB  1 
ATOM 68   N N   . ALA A 1 59  ? 123.909 112.484 134.491 1.00 35.78  ? 33  ALA A N   1 
ATOM 69   C CA  . ALA A 1 59  ? 124.718 113.042 135.574 1.00 35.78  ? 33  ALA A CA  1 
ATOM 70   C C   . ALA A 1 59  ? 125.740 114.050 135.056 1.00 35.78  ? 33  ALA A C   1 
ATOM 71   O O   . ALA A 1 59  ? 125.958 115.101 135.673 1.00 35.78  ? 33  ALA A O   1 
ATOM 72   C CB  . ALA A 1 59  ? 125.412 111.917 136.338 1.00 35.78  ? 33  ALA A CB  1 
ATOM 73   N N   . LEU A 1 60  ? 126.361 113.760 133.912 1.00 35.54  ? 34  LEU A N   1 
ATOM 74   C CA  . LEU A 1 60  ? 127.296 114.703 133.313 1.00 35.54  ? 34  LEU A CA  1 
ATOM 75   C C   . LEU A 1 60  ? 126.579 115.930 132.766 1.00 35.54  ? 34  LEU A C   1 
ATOM 76   O O   . LEU A 1 60  ? 127.154 117.022 132.756 1.00 35.54  ? 34  LEU A O   1 
ATOM 77   C CB  . LEU A 1 60  ? 128.100 114.014 132.213 1.00 35.54  ? 34  LEU A CB  1 
ATOM 78   C CG  . LEU A 1 60  ? 129.479 114.611 131.944 1.00 35.54  ? 34  LEU A CG  1 
ATOM 79   C CD1 . LEU A 1 60  ? 130.402 114.350 133.115 1.00 35.54  ? 34  LEU A CD1 1 
ATOM 80   C CD2 . LEU A 1 60  ? 130.065 114.044 130.678 1.00 35.54  ? 34  LEU A CD2 1 
ATOM 81   N N   . SER A 1 61  ? 125.327 115.776 132.323 1.00 36.20  ? 35  SER A N   1 
ATOM 82   C CA  . SER A 1 61  ? 124.515 116.932 131.959 1.00 36.20  ? 35  SER A CA  1 
ATOM 83   C C   . SER A 1 61  ? 124.258 117.824 133.163 1.00 36.20  ? 35  SER A C   1 
ATOM 84   O O   . SER A 1 61  ? 124.322 119.058 133.064 1.00 36.20  ? 35  SER A O   1 
ATOM 85   C CB  . SER A 1 61  ? 123.195 116.459 131.357 1.00 36.20  ? 35  SER A CB  1 
ATOM 86   O OG  . SER A 1 61  ? 122.411 117.553 130.939 1.00 36.20  ? 35  SER A OG  1 
ATOM 87   N N   . LEU A 1 62  ? 123.981 117.207 134.312 1.00 34.98  ? 36  LEU A N   1 
ATOM 88   C CA  . LEU A 1 62  ? 123.766 117.963 135.540 1.00 34.98  ? 36  LEU A CA  1 
ATOM 89   C C   . LEU A 1 62  ? 125.043 118.678 135.977 1.00 34.98  ? 36  LEU A C   1 
ATOM 90   O O   . LEU A 1 62  ? 124.994 119.819 136.453 1.00 34.98  ? 36  LEU A O   1 
ATOM 91   C CB  . LEU A 1 62  ? 123.247 117.018 136.622 1.00 34.98  ? 36  LEU A CB  1 
ATOM 92   C CG  . LEU A 1 62  ? 122.625 117.603 137.881 1.00 34.98  ? 36  LEU A CG  1 
ATOM 93   C CD1 . LEU A 1 62  ? 121.418 118.423 137.503 1.00 34.98  ? 36  LEU A CD1 1 
ATOM 94   C CD2 . LEU A 1 62  ? 122.219 116.477 138.810 1.00 34.98  ? 36  LEU A CD2 1 
ATOM 95   N N   . SER A 1 63  ? 126.200 118.041 135.775 1.00 34.01  ? 37  SER A N   1 
ATOM 96   C CA  . SER A 1 63  ? 127.478 118.692 136.073 1.00 34.01  ? 37  SER A CA  1 
ATOM 97   C C   . SER A 1 63  ? 127.782 119.836 135.112 1.00 34.01  ? 37  SER A C   1 
ATOM 98   O O   . SER A 1 63  ? 128.396 120.834 135.510 1.00 34.01  ? 37  SER A O   1 
ATOM 99   C CB  . SER A 1 63  ? 128.613 117.678 136.045 1.00 34.01  ? 37  SER A CB  1 
ATOM 100  O OG  . SER A 1 63  ? 128.444 116.737 137.077 1.00 34.01  ? 37  SER A OG  1 
ATOM 101  N N   . PHE A 1 64  ? 127.394 119.699 133.839 1.00 35.90  ? 38  PHE A N   1 
ATOM 102  C CA  . PHE A 1 64  ? 127.545 120.797 132.886 1.00 35.90  ? 38  PHE A CA  1 
ATOM 103  C C   . PHE A 1 64  ? 126.700 121.999 133.291 1.00 35.90  ? 38  PHE A C   1 
ATOM 104  O O   . PHE A 1 64  ? 127.170 123.147 133.236 1.00 35.90  ? 38  PHE A O   1 
ATOM 105  C CB  . PHE A 1 64  ? 127.159 120.333 131.482 1.00 35.90  ? 38  PHE A CB  1 
ATOM 106  C CG  . PHE A 1 64  ? 128.319 119.869 130.642 1.00 35.90  ? 38  PHE A CG  1 
ATOM 107  C CD1 . PHE A 1 64  ? 129.104 118.800 131.041 1.00 35.90  ? 38  PHE A CD1 1 
ATOM 108  C CD2 . PHE A 1 64  ? 128.613 120.499 129.443 1.00 35.90  ? 38  PHE A CD2 1 
ATOM 109  C CE1 . PHE A 1 64  ? 130.157 118.369 130.266 1.00 35.90  ? 38  PHE A CE1 1 
ATOM 110  C CE2 . PHE A 1 64  ? 129.670 120.074 128.664 1.00 35.90  ? 38  PHE A CE2 1 
ATOM 111  C CZ  . PHE A 1 64  ? 130.442 119.007 129.078 1.00 35.90  ? 38  PHE A CZ  1 
ATOM 112  N N   . ILE A 1 65  ? 125.457 121.742 133.721 1.00 33.81  ? 39  ILE A N   1 
ATOM 113  C CA  . ILE A 1 65  ? 124.589 122.803 134.237 1.00 33.81  ? 39  ILE A CA  1 
ATOM 114  C C   . ILE A 1 65  ? 125.212 123.452 135.465 1.00 33.81  ? 39  ILE A C   1 
ATOM 115  O O   . ILE A 1 65  ? 125.227 124.683 135.588 1.00 33.81  ? 39  ILE A O   1 
ATOM 116  C CB  . ILE A 1 65  ? 123.183 122.251 134.547 1.00 33.81  ? 39  ILE A CB  1 
ATOM 117  C CG1 . ILE A 1 65  ? 122.505 121.746 133.283 1.00 33.81  ? 39  ILE A CG1 1 
ATOM 118  C CG2 . ILE A 1 65  ? 122.299 123.311 135.179 1.00 33.81  ? 39  ILE A CG2 1 
ATOM 119  C CD1 . ILE A 1 65  ? 121.244 120.965 133.550 1.00 33.81  ? 39  ILE A CD1 1 
ATOM 120  N N   . ALA A 1 66  ? 125.775 122.636 136.365 1.00 33.89  ? 40  ALA A N   1 
ATOM 121  C CA  . ALA A 1 66  ? 126.382 123.153 137.590 1.00 33.89  ? 40  ALA A CA  1 
ATOM 122  C C   . ALA A 1 66  ? 127.597 124.032 137.305 1.00 33.89  ? 40  ALA A C   1 
ATOM 123  O O   . ALA A 1 66  ? 127.748 125.100 137.910 1.00 33.89  ? 40  ALA A O   1 
ATOM 124  C CB  . ALA A 1 66  ? 126.768 121.997 138.508 1.00 33.89  ? 40  ALA A CB  1 
ATOM 125  N N   . LYS A 1 67  ? 128.456 123.624 136.366 1.00 32.82  ? 41  LYS A N   1 
ATOM 126  C CA  . LYS A 1 67  ? 129.667 124.404 136.121 1.00 32.82  ? 41  LYS A CA  1 
ATOM 127  C C   . LYS A 1 67  ? 129.368 125.692 135.354 1.00 32.82  ? 41  LYS A C   1 
ATOM 128  O O   . LYS A 1 67  ? 129.958 126.742 135.655 1.00 32.82  ? 41  LYS A O   1 
ATOM 129  C CB  . LYS A 1 67  ? 130.726 123.553 135.414 1.00 32.82  ? 41  LYS A CB  1 
ATOM 130  C CG  . LYS A 1 67  ? 130.387 123.074 134.032 1.00 32.82  ? 41  LYS A CG  1 
ATOM 131  C CD  . LYS A 1 67  ? 131.554 122.378 133.385 1.00 32.82  ? 41  LYS A CD  1 
ATOM 132  C CE  . LYS A 1 67  ? 131.226 122.073 131.943 1.00 32.82  ? 41  LYS A CE  1 
ATOM 133  N NZ  . LYS A 1 67  ? 132.331 121.367 131.285 1.00 32.82  ? 41  LYS A NZ  1 
ATOM 134  N N   . THR A 1 68  ? 128.422 125.661 134.402 1.00 36.66  ? 42  THR A N   1 
ATOM 135  C CA  . THR A 1 68  ? 128.061 126.902 133.718 1.00 36.66  ? 42  THR A CA  1 
ATOM 136  C C   . THR A 1 68  ? 127.304 127.847 134.643 1.00 36.66  ? 42  THR A C   1 
ATOM 137  O O   . THR A 1 68  ? 127.490 129.072 134.575 1.00 36.66  ? 42  THR A O   1 
ATOM 138  C CB  . THR A 1 68  ? 127.248 126.605 132.461 1.00 36.66  ? 42  THR A CB  1 
ATOM 139  O OG1 . THR A 1 68  ? 126.037 125.930 132.819 1.00 36.66  ? 42  THR A OG1 1 
ATOM 140  C CG2 . THR A 1 68  ? 128.054 125.764 131.483 1.00 36.66  ? 42  THR A CG2 1 
ATOM 141  N N   . LEU A 1 69  ? 126.478 127.292 135.539 1.00 36.20  ? 43  LEU A N   1 
ATOM 142  C CA  . LEU A 1 69  ? 125.805 128.094 136.553 1.00 36.20  ? 43  LEU A CA  1 
ATOM 143  C C   . LEU A 1 69  ? 126.805 128.754 137.488 1.00 36.20  ? 43  LEU A C   1 
ATOM 144  O O   . LEU A 1 69  ? 126.669 129.939 137.801 1.00 36.20  ? 43  LEU A O   1 
ATOM 145  C CB  . LEU A 1 69  ? 124.829 127.218 137.340 1.00 36.20  ? 43  LEU A CB  1 
ATOM 146  C CG  . LEU A 1 69  ? 124.372 127.662 138.731 1.00 36.20  ? 43  LEU A CG  1 
ATOM 147  C CD1 . LEU A 1 69  ? 123.435 128.850 138.649 1.00 36.20  ? 43  LEU A CD1 1 
ATOM 148  C CD2 . LEU A 1 69  ? 123.709 126.512 139.468 1.00 36.20  ? 43  LEU A CD2 1 
ATOM 149  N N   . GLY A 1 70  ? 127.830 128.009 137.917 1.00 36.31  ? 44  GLY A N   1 
ATOM 150  C CA  . GLY A 1 70  ? 128.846 128.584 138.785 1.00 36.31  ? 44  GLY A CA  1 
ATOM 151  C C   . GLY A 1 70  ? 129.650 129.679 138.112 1.00 36.31  ? 44  GLY A C   1 
ATOM 152  O O   . GLY A 1 70  ? 129.990 130.685 138.743 1.00 36.31  ? 44  GLY A O   1 
ATOM 153  N N   . ALA A 1 71  ? 129.936 129.511 136.814 1.00 36.10  ? 45  ALA A N   1 
ATOM 154  C CA  . ALA A 1 71  ? 130.623 130.557 136.058 1.00 36.10  ? 45  ALA A CA  1 
ATOM 155  C C   . ALA A 1 71  ? 129.786 131.830 135.961 1.00 36.10  ? 45  ALA A C   1 
ATOM 156  O O   . ALA A 1 71  ? 130.304 132.939 136.166 1.00 36.10  ? 45  ALA A O   1 
ATOM 157  C CB  . ALA A 1 71  ? 130.976 130.045 134.665 1.00 36.10  ? 45  ALA A CB  1 
ATOM 158  N N   . ILE A 1 72  ? 128.484 131.689 135.683 1.00 37.91  ? 46  ILE A N   1 
ATOM 159  C CA  . ILE A 1 72  ? 127.614 132.859 135.554 1.00 37.91  ? 46  ILE A CA  1 
ATOM 160  C C   . ILE A 1 72  ? 127.432 133.555 136.902 1.00 37.91  ? 46  ILE A C   1 
ATOM 161  O O   . ILE A 1 72  ? 127.437 134.790 136.982 1.00 37.91  ? 46  ILE A O   1 
ATOM 162  C CB  . ILE A 1 72  ? 126.271 132.446 134.920 1.00 37.91  ? 46  ILE A CB  1 
ATOM 163  C CG1 . ILE A 1 72  ? 126.482 131.995 133.474 1.00 37.91  ? 46  ILE A CG1 1 
ATOM 164  C CG2 . ILE A 1 72  ? 125.267 133.582 134.935 1.00 37.91  ? 46  ILE A CG2 1 
ATOM 165  C CD1 . ILE A 1 72  ? 127.288 132.962 132.626 1.00 37.91  ? 46  ILE A CD1 1 
ATOM 166  N N   . ILE A 1 73  ? 127.311 132.774 137.980 1.00 39.20  ? 47  ILE A N   1 
ATOM 167  C CA  . ILE A 1 73  ? 127.204 133.324 139.334 1.00 39.20  ? 47  ILE A CA  1 
ATOM 168  C C   . ILE A 1 73  ? 128.462 134.092 139.732 1.00 39.20  ? 47  ILE A C   1 
ATOM 169  O O   . ILE A 1 73  ? 128.378 135.201 140.286 1.00 39.20  ? 47  ILE A O   1 
ATOM 170  C CB  . ILE A 1 73  ? 126.875 132.189 140.325 1.00 39.20  ? 47  ILE A CB  1 
ATOM 171  C CG1 . ILE A 1 73  ? 125.429 131.708 140.134 1.00 39.20  ? 47  ILE A CG1 1 
ATOM 172  C CG2 . ILE A 1 73  ? 127.273 132.524 141.747 1.00 39.20  ? 47  ILE A CG2 1 
ATOM 173  C CD1 . ILE A 1 73  ? 124.380 132.645 140.656 1.00 39.20  ? 47  ILE A CD1 1 
ATOM 174  N N   . MET A 1 74  ? 129.642 133.527 139.448 1.00 41.08  ? 48  MET A N   1 
ATOM 175  C CA  . MET A 1 74  ? 130.888 134.212 139.779 1.00 41.08  ? 48  MET A CA  1 
ATOM 176  C C   . MET A 1 74  ? 131.064 135.481 138.955 1.00 41.08  ? 48  MET A C   1 
ATOM 177  O O   . MET A 1 74  ? 131.611 136.475 139.448 1.00 41.08  ? 48  MET A O   1 
ATOM 178  C CB  . MET A 1 74  ? 132.075 133.271 139.586 1.00 41.08  ? 48  MET A CB  1 
ATOM 179  C CG  . MET A 1 74  ? 133.402 133.855 140.040 1.00 41.08  ? 48  MET A CG  1 
ATOM 180  S SD  . MET A 1 74  ? 133.468 134.152 141.813 1.00 41.08  ? 48  MET A SD  1 
ATOM 181  C CE  . MET A 1 74  ? 134.708 135.439 141.886 1.00 41.08  ? 48  MET A CE  1 
ATOM 182  N N   . LYS A 1 75  ? 130.584 135.481 137.710 1.00 42.94  ? 49  LYS A N   1 
ATOM 183  C CA  . LYS A 1 75  ? 130.649 136.707 136.920 1.00 42.94  ? 49  LYS A CA  1 
ATOM 184  C C   . LYS A 1 75  ? 129.667 137.762 137.427 1.00 42.94  ? 49  LYS A C   1 
ATOM 185  O O   . LYS A 1 75  ? 129.986 138.956 137.437 1.00 42.94  ? 49  LYS A O   1 
ATOM 186  C CB  . LYS A 1 75  ? 130.397 136.397 135.446 1.00 42.94  ? 49  LYS A CB  1 
ATOM 187  C CG  . LYS A 1 75  ? 130.989 137.422 134.486 1.00 42.94  ? 49  LYS A CG  1 
ATOM 188  C CD  . LYS A 1 75  ? 132.393 137.860 134.895 1.00 42.94  ? 49  LYS A CD  1 
ATOM 189  C CE  . LYS A 1 75  ? 133.040 138.704 133.814 1.00 42.94  ? 49  LYS A CE  1 
ATOM 190  N NZ  . LYS A 1 75  ? 132.084 139.689 133.241 1.00 42.94  ? 49  LYS A NZ  1 
ATOM 191  N N   . SER A 1 76  ? 128.476 137.346 137.864 1.00 40.55  ? 50  SER A N   1 
ATOM 192  C CA  . SER A 1 76  ? 127.429 138.311 138.186 1.00 40.55  ? 50  SER A CA  1 
ATOM 193  C C   . SER A 1 76  ? 127.572 138.916 139.577 1.00 40.55  ? 50  SER A C   1 
ATOM 194  O O   . SER A 1 76  ? 127.231 140.088 139.766 1.00 40.55  ? 50  SER A O   1 
ATOM 195  C CB  . SER A 1 76  ? 126.054 137.658 138.054 1.00 40.55  ? 50  SER A CB  1 
ATOM 196  O OG  . SER A 1 76  ? 125.859 136.669 139.046 1.00 40.55  ? 50  SER A OG  1 
ATOM 197  N N   . SER A 1 77  ? 128.060 138.160 140.560 1.00 41.13  ? 51  SER A N   1 
ATOM 198  C CA  . SER A 1 77  ? 128.085 138.635 141.942 1.00 41.13  ? 51  SER A CA  1 
ATOM 199  C C   . SER A 1 77  ? 129.332 139.446 142.282 1.00 41.13  ? 51  SER A C   1 
ATOM 200  O O   . SER A 1 77  ? 129.506 139.850 143.442 1.00 41.13  ? 51  SER A O   1 
ATOM 201  C CB  . SER A 1 77  ? 127.971 137.452 142.897 1.00 41.13  ? 51  SER A CB  1 
ATOM 202  O OG  . SER A 1 77  ? 129.082 136.597 142.738 1.00 41.13  ? 51  SER A OG  1 
ATOM 203  N N   . ILE A 1 78  ? 130.189 139.707 141.295 1.00 41.54  ? 52  ILE A N   1 
ATOM 204  C CA  . ILE A 1 78  ? 131.510 140.250 141.575 1.00 41.54  ? 52  ILE A CA  1 
ATOM 205  C C   . ILE A 1 78  ? 131.440 141.735 141.932 1.00 41.54  ? 52  ILE A C   1 
ATOM 206  O O   . ILE A 1 78  ? 132.298 142.240 142.667 1.00 41.54  ? 52  ILE A O   1 
ATOM 207  C CB  . ILE A 1 78  ? 132.437 139.951 140.379 1.00 41.54  ? 52  ILE A CB  1 
ATOM 208  C CG1 . ILE A 1 78  ? 133.892 140.021 140.803 1.00 41.54  ? 52  ILE A CG1 1 
ATOM 209  C CG2 . ILE A 1 78  ? 132.179 140.876 139.197 1.00 41.54  ? 52  ILE A CG2 1 
ATOM 210  C CD1 . ILE A 1 78  ? 134.837 139.383 139.830 1.00 41.54  ? 52  ILE A CD1 1 
ATOM 211  N N   . ILE A 1 79  ? 130.395 142.440 141.487 1.00 41.28  ? 53  ILE A N   1 
ATOM 212  C CA  . ILE A 1 79  ? 130.225 143.846 141.845 1.00 41.28  ? 53  ILE A CA  1 
ATOM 213  C C   . ILE A 1 79  ? 129.858 143.975 143.318 1.00 41.28  ? 53  ILE A C   1 
ATOM 214  O O   . ILE A 1 79  ? 130.409 144.812 144.047 1.00 41.28  ? 53  ILE A O   1 
ATOM 215  C CB  . ILE A 1 79  ? 129.170 144.500 140.935 1.00 41.28  ? 53  ILE A CB  1 
ATOM 216  C CG1 . ILE A 1 79  ? 129.640 144.481 139.479 1.00 41.28  ? 53  ILE A CG1 1 
ATOM 217  C CG2 . ILE A 1 79  ? 128.872 145.923 141.374 1.00 41.28  ? 53  ILE A CG2 1 
ATOM 218  C CD1 . ILE A 1 79  ? 130.898 145.287 139.227 1.00 41.28  ? 53  ILE A CD1 1 
ATOM 219  N N   . HIS A 1 80  ? 128.945 143.117 143.782 1.00 39.43  ? 54  HIS A N   1 
ATOM 220  C CA  . HIS A 1 80  ? 128.579 143.098 145.194 1.00 39.43  ? 54  HIS A CA  1 
ATOM 221  C C   . HIS A 1 80  ? 129.744 142.646 146.062 1.00 39.43  ? 54  HIS A C   1 
ATOM 222  O O   . HIS A 1 80  ? 129.907 143.133 147.185 1.00 39.43  ? 54  HIS A O   1 
ATOM 223  C CB  . HIS A 1 80  ? 127.374 142.186 145.415 1.00 39.43  ? 54  HIS A CB  1 
ATOM 224  C CG  . HIS A 1 80  ? 126.115 142.679 144.779 1.00 39.43  ? 54  HIS A CG  1 
ATOM 225  N ND1 . HIS A 1 80  ? 125.767 144.012 144.751 1.00 39.43  ? 54  HIS A ND1 1 
ATOM 226  C CD2 . HIS A 1 80  ? 125.110 142.015 144.161 1.00 39.43  ? 54  HIS A CD2 1 
ATOM 227  C CE1 . HIS A 1 80  ? 124.608 144.148 144.134 1.00 39.43  ? 54  HIS A CE1 1 
ATOM 228  N NE2 . HIS A 1 80  ? 124.187 142.951 143.768 1.00 39.43  ? 54  HIS A NE2 1 
ATOM 229  N N   . ILE A 1 81  ? 130.563 141.712 145.559 1.00 38.23  ? 55  ILE A N   1 
ATOM 230  C CA  . ILE A 1 81  ? 131.750 141.281 146.301 1.00 38.23  ? 55  ILE A CA  1 
ATOM 231  C C   . ILE A 1 81  ? 132.746 142.430 146.446 1.00 38.23  ? 55  ILE A C   1 
ATOM 232  O O   . ILE A 1 81  ? 133.270 142.682 147.541 1.00 38.23  ? 55  ILE A O   1 
ATOM 233  C CB  . ILE A 1 81  ? 132.385 140.053 145.622 1.00 38.23  ? 55  ILE A CB  1 
ATOM 234  C CG1 . ILE A 1 81  ? 131.556 138.806 145.900 1.00 38.23  ? 55  ILE A CG1 1 
ATOM 235  C CG2 . ILE A 1 81  ? 133.806 139.820 146.101 1.00 38.23  ? 55  ILE A CG2 1 
ATOM 236  C CD1 . ILE A 1 81  ? 132.024 137.612 145.128 1.00 38.23  ? 55  ILE A CD1 1 
ATOM 237  N N   . GLU A 1 82  ? 132.986 143.168 145.357 1.00 42.75  ? 56  GLU A N   1 
ATOM 238  C CA  . GLU A 1 82  ? 133.901 144.307 145.395 1.00 42.75  ? 56  GLU A CA  1 
ATOM 239  C C   . GLU A 1 82  ? 133.384 145.414 146.309 1.00 42.75  ? 56  GLU A C   1 
ATOM 240  O O   . GLU A 1 82  ? 134.172 146.096 146.974 1.00 42.75  ? 56  GLU A O   1 
ATOM 241  C CB  . GLU A 1 82  ? 134.119 144.835 143.977 1.00 42.75  ? 56  GLU A CB  1 
ATOM 242  C CG  . GLU A 1 82  ? 135.133 145.958 143.849 1.00 42.75  ? 56  GLU A CG  1 
ATOM 243  C CD  . GLU A 1 82  ? 135.188 146.523 142.445 1.00 42.75  ? 56  GLU A CD  1 
ATOM 244  O OE1 . GLU A 1 82  ? 134.919 145.767 141.490 1.00 42.75  ? 56  GLU A OE1 1 
ATOM 245  O OE2 . GLU A 1 82  ? 135.492 147.724 142.296 1.00 42.75  ? 56  GLU A OE2 1 
ATOM 246  N N   . ARG A 1 83  ? 132.063 145.598 146.369 1.00 43.89  ? 57  ARG A N   1 
ATOM 247  C CA  . ARG A 1 83  ? 131.514 146.611 147.267 1.00 43.89  ? 57  ARG A CA  1 
ATOM 248  C C   . ARG A 1 83  ? 131.576 146.171 148.727 1.00 43.89  ? 57  ARG A C   1 
ATOM 249  O O   . ARG A 1 83  ? 131.889 146.980 149.607 1.00 43.89  ? 57  ARG A O   1 
ATOM 250  C CB  . ARG A 1 83  ? 130.079 146.943 146.873 1.00 43.89  ? 57  ARG A CB  1 
ATOM 251  C CG  . ARG A 1 83  ? 129.972 147.977 145.773 1.00 43.89  ? 57  ARG A CG  1 
ATOM 252  C CD  . ARG A 1 83  ? 128.523 148.272 145.443 1.00 43.89  ? 57  ARG A CD  1 
ATOM 253  N NE  . ARG A 1 83  ? 128.399 149.208 144.335 1.00 43.89  ? 57  ARG A NE  1 
ATOM 254  C CZ  . ARG A 1 83  ? 127.266 149.457 143.696 1.00 43.89  ? 57  ARG A CZ  1 
ATOM 255  N NH1 . ARG A 1 83  ? 126.138 148.858 144.035 1.00 43.89  ? 57  ARG A NH1 1 
ATOM 256  N NH2 . ARG A 1 83  ? 127.265 150.330 142.694 1.00 43.89  ? 57  ARG A NH2 1 
ATOM 257  N N   . ARG A 1 84  ? 131.274 144.900 149.006 1.00 37.60  ? 58  ARG A N   1 
ATOM 258  C CA  . ARG A 1 84  ? 131.200 144.431 150.387 1.00 37.60  ? 58  ARG A CA  1 
ATOM 259  C C   . ARG A 1 84  ? 132.581 144.317 151.016 1.00 37.60  ? 58  ARG A C   1 
ATOM 260  O O   . ARG A 1 84  ? 132.790 144.748 152.155 1.00 37.60  ? 58  ARG A O   1 
ATOM 261  C CB  . ARG A 1 84  ? 130.480 143.085 150.441 1.00 37.60  ? 58  ARG A CB  1 
ATOM 262  C CG  . ARG A 1 84  ? 130.332 142.509 151.836 1.00 37.60  ? 58  ARG A CG  1 
ATOM 263  C CD  . ARG A 1 84  ? 129.333 143.288 152.662 1.00 37.60  ? 58  ARG A CD  1 
ATOM 264  N NE  . ARG A 1 84  ? 129.177 142.731 154.001 1.00 37.60  ? 58  ARG A NE  1 
ATOM 265  C CZ  . ARG A 1 84  ? 129.977 142.995 155.025 1.00 37.60  ? 58  ARG A CZ  1 
ATOM 266  N NH1 . ARG A 1 84  ? 130.999 143.825 154.909 1.00 37.60  ? 58  ARG A NH1 1 
ATOM 267  N NH2 . ARG A 1 84  ? 129.741 142.416 156.197 1.00 37.60  ? 58  ARG A NH2 1 
ATOM 268  N N   . PHE A 1 85  ? 133.541 143.741 150.293 1.00 36.68  ? 59  PHE A N   1 
ATOM 269  C CA  . PHE A 1 85  ? 134.862 143.546 150.876 1.00 36.68  ? 59  PHE A CA  1 
ATOM 270  C C   . PHE A 1 85  ? 135.753 144.771 150.754 1.00 36.68  ? 59  PHE A C   1 
ATOM 271  O O   . PHE A 1 85  ? 136.864 144.747 151.295 1.00 36.68  ? 59  PHE A O   1 
ATOM 272  C CB  . PHE A 1 85  ? 135.551 142.345 150.235 1.00 36.68  ? 59  PHE A CB  1 
ATOM 273  C CG  . PHE A 1 85  ? 134.910 141.039 150.567 1.00 36.68  ? 59  PHE A CG  1 
ATOM 274  C CD1 . PHE A 1 85  ? 135.231 140.373 151.733 1.00 36.68  ? 59  PHE A CD1 1 
ATOM 275  C CD2 . PHE A 1 85  ? 133.981 140.479 149.714 1.00 36.68  ? 59  PHE A CD2 1 
ATOM 276  C CE1 . PHE A 1 85  ? 134.636 139.170 152.035 1.00 36.68  ? 59  PHE A CE1 1 
ATOM 277  C CE2 . PHE A 1 85  ? 133.385 139.281 150.010 1.00 36.68  ? 59  PHE A CE2 1 
ATOM 278  C CZ  . PHE A 1 85  ? 133.712 138.627 151.168 1.00 36.68  ? 59  PHE A CZ  1 
ATOM 279  N N   . GLU A 1 86  ? 135.283 145.818 150.064 1.00 42.02  ? 60  GLU A N   1 
ATOM 280  C CA  . GLU A 1 86  ? 135.989 147.092 149.878 1.00 42.02  ? 60  GLU A CA  1 
ATOM 281  C C   . GLU A 1 86  ? 137.364 146.903 149.246 1.00 42.02  ? 60  GLU A C   1 
ATOM 282  O O   . GLU A 1 86  ? 138.330 147.572 149.617 1.00 42.02  ? 60  GLU A O   1 
ATOM 283  C CB  . GLU A 1 86  ? 136.098 147.871 151.193 1.00 42.02  ? 60  GLU A CB  1 
ATOM 284  C CG  . GLU A 1 86  ? 134.783 147.979 151.947 1.00 42.02  ? 60  GLU A CG  1 
ATOM 285  C CD  . GLU A 1 86  ? 134.727 149.185 152.855 1.00 42.02  ? 60  GLU A CD  1 
ATOM 286  O OE1 . GLU A 1 86  ? 135.747 149.486 153.510 1.00 42.02  ? 60  GLU A OE1 1 
ATOM 287  O OE2 . GLU A 1 86  ? 133.663 149.834 152.914 1.00 42.02  ? 60  GLU A OE2 1 
ATOM 288  N N   . ILE A 1 87  ? 137.456 145.996 148.294 1.00 41.99  ? 61  ILE A N   1 
ATOM 289  C CA  . ILE A 1 87  ? 138.712 145.671 147.635 1.00 41.99  ? 61  ILE A CA  1 
ATOM 290  C C   . ILE A 1 87  ? 138.807 146.425 146.318 1.00 41.99  ? 61  ILE A C   1 
ATOM 291  O O   . ILE A 1 87  ? 137.795 146.854 145.752 1.00 41.99  ? 61  ILE A O   1 
ATOM 292  C CB  . ILE A 1 87  ? 138.837 144.150 147.437 1.00 41.99  ? 61  ILE A CB  1 
ATOM 293  C CG1 . ILE A 1 87  ? 137.718 143.634 146.545 1.00 41.99  ? 61  ILE A CG1 1 
ATOM 294  C CG2 . ILE A 1 87  ? 138.821 143.441 148.767 1.00 41.99  ? 61  ILE A CG2 1 
ATOM 295  C CD1 . ILE A 1 87  ? 137.905 142.217 146.132 1.00 41.99  ? 61  ILE A CD1 1 
ATOM 296  N N   . SER A 1 88  ? 140.035 146.599 145.838 1.00 47.62  ? 62  SER A N   1 
ATOM 297  C CA  . SER A 1 88  ? 140.292 147.401 144.653 1.00 47.62  ? 62  SER A CA  1 
ATOM 298  C C   . SER A 1 88  ? 140.052 146.581 143.385 1.00 47.62  ? 62  SER A C   1 
ATOM 299  O O   . SER A 1 88  ? 139.662 145.412 143.425 1.00 47.62  ? 62  SER A O   1 
ATOM 300  C CB  . SER A 1 88  ? 141.715 147.948 144.693 1.00 47.62  ? 62  SER A CB  1 
ATOM 301  O OG  . SER A 1 88  ? 142.639 146.927 145.027 1.00 47.62  ? 62  SER A OG  1 
ATOM 302  N N   . SER A 1 89  ? 140.295 147.220 142.238 1.00 47.93  ? 63  SER A N   1 
ATOM 303  C CA  . SER A 1 89  ? 140.051 146.570 140.954 1.00 47.93  ? 63  SER A CA  1 
ATOM 304  C C   . SER A 1 89  ? 141.106 145.514 140.648 1.00 47.93  ? 63  SER A C   1 
ATOM 305  O O   . SER A 1 89  ? 140.797 144.476 140.049 1.00 47.93  ? 63  SER A O   1 
ATOM 306  C CB  . SER A 1 89  ? 139.999 147.617 139.843 1.00 47.93  ? 63  SER A CB  1 
ATOM 307  O OG  . SER A 1 89  ? 139.205 148.725 140.228 1.00 47.93  ? 63  SER A OG  1 
ATOM 308  N N   . SER A 1 90  ? 142.358 145.768 141.038 1.00 48.22  ? 64  SER A N   1 
ATOM 309  C CA  . SER A 1 90  ? 143.422 144.795 140.808 1.00 48.22  ? 64  SER A CA  1 
ATOM 310  C C   . SER A 1 90  ? 143.212 143.537 141.640 1.00 48.22  ? 64  SER A C   1 
ATOM 311  O O   . SER A 1 90  ? 143.407 142.417 141.150 1.00 48.22  ? 64  SER A O   1 
ATOM 312  C CB  . SER A 1 90  ? 144.778 145.423 141.121 1.00 48.22  ? 64  SER A CB  1 
ATOM 313  O OG  . SER A 1 90  ? 144.746 146.102 142.364 1.00 48.22  ? 64  SER A OG  1 
ATOM 314  N N   . LEU A 1 91  ? 142.793 143.704 142.898 1.00 44.88  ? 65  LEU A N   1 
ATOM 315  C CA  . LEU A 1 91  ? 142.547 142.559 143.770 1.00 44.88  ? 65  LEU A CA  1 
ATOM 316  C C   . LEU A 1 91  ? 141.354 141.741 143.296 1.00 44.88  ? 65  LEU A C   1 
ATOM 317  O O   . LEU A 1 91  ? 141.385 140.504 143.339 1.00 44.88  ? 65  LEU A O   1 
ATOM 318  C CB  . LEU A 1 91  ? 142.331 143.036 145.202 1.00 44.88  ? 65  LEU A CB  1 
ATOM 319  C CG  . LEU A 1 91  ? 142.714 142.071 146.317 1.00 44.88  ? 65  LEU A CG  1 
ATOM 320  C CD1 . LEU A 1 91  ? 144.186 141.725 146.241 1.00 44.88  ? 65  LEU A CD1 1 
ATOM 321  C CD2 . LEU A 1 91  ? 142.385 142.707 147.647 1.00 44.88  ? 65  LEU A CD2 1 
ATOM 322  N N   . VAL A 1 92  ? 140.299 142.406 142.823 1.00 45.37  ? 66  VAL A N   1 
ATOM 323  C CA  . VAL A 1 92  ? 139.127 141.660 142.383 1.00 45.37  ? 66  VAL A CA  1 
ATOM 324  C C   . VAL A 1 92  ? 139.399 141.002 141.031 1.00 45.37  ? 66  VAL A C   1 
ATOM 325  O O   . VAL A 1 92  ? 138.864 139.927 140.731 1.00 45.37  ? 66  VAL A O   1 
ATOM 326  C CB  . VAL A 1 92  ? 137.878 142.569 142.377 1.00 45.37  ? 66  VAL A CB  1 
ATOM 327  C CG1 . VAL A 1 92  ? 137.866 143.570 141.234 1.00 45.37  ? 66  VAL A CG1 1 
ATOM 328  C CG2 . VAL A 1 92  ? 136.624 141.752 142.416 1.00 45.37  ? 66  VAL A CG2 1 
ATOM 329  N N   . GLY A 1 93  ? 140.294 141.591 140.229 1.00 44.88  ? 67  GLY A N   1 
ATOM 330  C CA  . GLY A 1 93  ? 140.771 140.907 139.038 1.00 44.88  ? 67  GLY A CA  1 
ATOM 331  C C   . GLY A 1 93  ? 141.617 139.691 139.367 1.00 44.88  ? 67  GLY A C   1 
ATOM 332  O O   . GLY A 1 93  ? 141.575 138.685 138.655 1.00 44.88  ? 67  GLY A O   1 
ATOM 333  N N   . PHE A 1 94  ? 142.400 139.773 140.445 1.00 43.88  ? 68  PHE A N   1 
ATOM 334  C CA  . PHE A 1 94  ? 143.167 138.621 140.915 1.00 43.88  ? 68  PHE A CA  1 
ATOM 335  C C   . PHE A 1 94  ? 142.247 137.495 141.375 1.00 43.88  ? 68  PHE A C   1 
ATOM 336  O O   . PHE A 1 94  ? 142.500 136.316 141.091 1.00 43.88  ? 68  PHE A O   1 
ATOM 337  C CB  . PHE A 1 94  ? 144.101 139.056 142.044 1.00 43.88  ? 68  PHE A CB  1 
ATOM 338  C CG  . PHE A 1 94  ? 145.032 137.982 142.517 1.00 43.88  ? 68  PHE A CG  1 
ATOM 339  C CD1 . PHE A 1 94  ? 145.861 137.321 141.624 1.00 43.88  ? 68  PHE A CD1 1 
ATOM 340  C CD2 . PHE A 1 94  ? 145.091 137.643 143.860 1.00 43.88  ? 68  PHE A CD2 1 
ATOM 341  C CE1 . PHE A 1 94  ? 146.726 136.332 142.061 1.00 43.88  ? 68  PHE A CE1 1 
ATOM 342  C CE2 . PHE A 1 94  ? 145.955 136.656 144.306 1.00 43.88  ? 68  PHE A CE2 1 
ATOM 343  C CZ  . PHE A 1 94  ? 146.772 135.999 143.406 1.00 43.88  ? 68  PHE A CZ  1 
ATOM 344  N N   . ILE A 1 95  ? 141.162 137.847 142.071 1.00 41.80  ? 69  ILE A N   1 
ATOM 345  C CA  . ILE A 1 95  ? 140.182 136.851 142.505 1.00 41.80  ? 69  ILE A CA  1 
ATOM 346  C C   . ILE A 1 95  ? 139.461 136.241 141.305 1.00 41.80  ? 69  ILE A C   1 
ATOM 347  O O   . ILE A 1 95  ? 139.174 135.037 141.283 1.00 41.80  ? 69  ILE A O   1 
ATOM 348  C CB  . ILE A 1 95  ? 139.204 137.481 143.514 1.00 41.80  ? 69  ILE A CB  1 
ATOM 349  C CG1 . ILE A 1 95  ? 139.961 137.916 144.762 1.00 41.80  ? 69  ILE A CG1 1 
ATOM 350  C CG2 . ILE A 1 95  ? 138.113 136.518 143.926 1.00 41.80  ? 69  ILE A CG2 1 
ATOM 351  C CD1 . ILE A 1 95  ? 139.147 138.758 145.674 1.00 41.80  ? 69  ILE A CD1 1 
ATOM 352  N N   . ASP A 1 96  ? 139.180 137.053 140.279 1.00 44.89  ? 70  ASP A N   1 
ATOM 353  C CA  . ASP A 1 96  ? 138.590 136.525 139.050 1.00 44.89  ? 70  ASP A CA  1 
ATOM 354  C C   . ASP A 1 96  ? 139.544 135.581 138.325 1.00 44.89  ? 70  ASP A C   1 
ATOM 355  O O   . ASP A 1 96  ? 139.127 134.524 137.839 1.00 44.89  ? 70  ASP A O   1 
ATOM 356  C CB  . ASP A 1 96  ? 138.181 137.672 138.129 1.00 44.89  ? 70  ASP A CB  1 
ATOM 357  C CG  . ASP A 1 96  ? 136.850 137.426 137.452 1.00 44.89  ? 70  ASP A CG  1 
ATOM 358  O OD1 . ASP A 1 96  ? 136.435 136.253 137.357 1.00 44.89  ? 70  ASP A OD1 1 
ATOM 359  O OD2 . ASP A 1 96  ? 136.227 138.405 136.996 1.00 44.89  ? 70  ASP A OD2 1 
ATOM 360  N N   . GLY A 1 97  ? 140.827 135.934 138.254 1.00 40.00  ? 71  GLY A N   1 
ATOM 361  C CA  . GLY A 1 97  ? 141.812 135.099 137.588 1.00 40.00  ? 71  GLY A CA  1 
ATOM 362  C C   . GLY A 1 97  ? 142.277 133.897 138.375 1.00 40.00  ? 71  GLY A C   1 
ATOM 363  O O   . GLY A 1 97  ? 143.006 133.058 137.832 1.00 40.00  ? 71  GLY A O   1 
ATOM 364  N N   . SER A 1 98  ? 141.881 133.811 139.649 1.00 36.69  ? 72  SER A N   1 
ATOM 365  C CA  . SER A 1 98  ? 142.165 132.627 140.456 1.00 36.69  ? 72  SER A CA  1 
ATOM 366  C C   . SER A 1 98  ? 141.556 131.359 139.875 1.00 36.69  ? 72  SER A C   1 
ATOM 367  O O   . SER A 1 98  ? 142.102 130.270 140.072 1.00 36.69  ? 72  SER A O   1 
ATOM 368  C CB  . SER A 1 98  ? 141.644 132.831 141.868 1.00 36.69  ? 72  SER A CB  1 
ATOM 369  O OG  . SER A 1 98  ? 140.243 133.012 141.867 1.00 36.69  ? 72  SER A OG  1 
ATOM 370  N N   . PHE A 1 99  ? 140.426 131.476 139.175 1.00 35.84  ? 73  PHE A N   1 
ATOM 371  C CA  . PHE A 1 99  ? 139.817 130.315 138.537 1.00 35.84  ? 73  PHE A CA  1 
ATOM 372  C C   . PHE A 1 99  ? 140.709 129.784 137.423 1.00 35.84  ? 73  PHE A C   1 
ATOM 373  O O   . PHE A 1 99  ? 140.905 128.570 137.296 1.00 35.84  ? 73  PHE A O   1 
ATOM 374  C CB  . PHE A 1 99  ? 138.435 130.689 138.005 1.00 35.84  ? 73  PHE A CB  1 
ATOM 375  C CG  . PHE A 1 99  ? 137.875 129.714 137.024 1.00 35.84  ? 73  PHE A CG  1 
ATOM 376  C CD1 . PHE A 1 99  ? 137.438 128.474 137.439 1.00 35.84  ? 73  PHE A CD1 1 
ATOM 377  C CD2 . PHE A 1 99  ? 137.756 130.047 135.691 1.00 35.84  ? 73  PHE A CD2 1 
ATOM 378  C CE1 . PHE A 1 99  ? 136.920 127.575 136.539 1.00 35.84  ? 73  PHE A CE1 1 
ATOM 379  C CE2 . PHE A 1 99  ? 137.240 129.155 134.786 1.00 35.84  ? 73  PHE A CE2 1 
ATOM 380  C CZ  . PHE A 1 99  ? 136.822 127.918 135.211 1.00 35.84  ? 73  PHE A CZ  1 
ATOM 381  N N   . GLU A 1 100 ? 141.287 130.693 136.628 1.00 36.72  ? 74  GLU A N   1 
ATOM 382  C CA  . GLU A 1 100 ? 142.257 130.307 135.607 1.00 36.72  ? 74  GLU A CA  1 
ATOM 383  C C   . GLU A 1 100 ? 143.508 129.704 136.229 1.00 36.72  ? 74  GLU A C   1 
ATOM 384  O O   . GLU A 1 100 ? 144.037 128.705 135.725 1.00 36.72  ? 74  GLU A O   1 
ATOM 385  C CB  . GLU A 1 100 ? 142.642 131.520 134.760 1.00 36.72  ? 74  GLU A CB  1 
ATOM 386  C CG  . GLU A 1 100 ? 141.525 132.310 134.063 1.00 36.72  ? 74  GLU A CG  1 
ATOM 387  C CD  . GLU A 1 100 ? 140.395 131.478 133.475 1.00 36.72  ? 74  GLU A CD  1 
ATOM 388  O OE1 . GLU A 1 100 ? 140.655 130.454 132.804 1.00 36.72  ? 74  GLU A OE1 1 
ATOM 389  O OE2 . GLU A 1 100 ? 139.231 131.893 133.638 1.00 36.72  ? 74  GLU A OE2 1 
ATOM 390  N N   . ILE A 1 101 ? 143.984 130.304 137.327 1.00 34.23  ? 75  ILE A N   1 
ATOM 391  C CA  . ILE A 1 101 ? 145.189 129.829 138.011 1.00 34.23  ? 75  ILE A CA  1 
ATOM 392  C C   . ILE A 1 101 ? 144.989 128.411 138.535 1.00 34.23  ? 75  ILE A C   1 
ATOM 393  O O   . ILE A 1 101 ? 145.846 127.538 138.359 1.00 34.23  ? 75  ILE A O   1 
ATOM 394  C CB  . ILE A 1 101 ? 145.577 130.797 139.145 1.00 34.23  ? 75  ILE A CB  1 
ATOM 395  C CG1 . ILE A 1 101 ? 146.045 132.136 138.579 1.00 34.23  ? 75  ILE A CG1 1 
ATOM 396  C CG2 . ILE A 1 101 ? 146.665 130.210 140.025 1.00 34.23  ? 75  ILE A CG2 1 
ATOM 397  C CD1 . ILE A 1 101 ? 146.264 133.193 139.637 1.00 34.23  ? 75  ILE A CD1 1 
ATOM 398  N N   . GLY A 1 102 ? 143.838 128.155 139.159 1.00 33.72  ? 76  GLY A N   1 
ATOM 399  C CA  . GLY A 1 102 ? 143.546 126.813 139.635 1.00 33.72  ? 76  GLY A CA  1 
ATOM 400  C C   . GLY A 1 102 ? 143.317 125.814 138.516 1.00 33.72  ? 76  GLY A C   1 
ATOM 401  O O   . GLY A 1 102 ? 143.770 124.671 138.598 1.00 33.72  ? 76  GLY A O   1 
ATOM 402  N N   . ASN A 1 103 ? 142.623 126.231 137.453 1.00 32.54  ? 77  ASN A N   1 
ATOM 403  C CA  . ASN A 1 103 ? 142.211 125.299 136.408 1.00 32.54  ? 77  ASN A CA  1 
ATOM 404  C C   . ASN A 1 103 ? 143.387 124.865 135.541 1.00 32.54  ? 77  ASN A C   1 
ATOM 405  O O   . ASN A 1 103 ? 143.554 123.669 135.257 1.00 32.54  ? 77  ASN A O   1 
ATOM 406  C CB  . ASN A 1 103 ? 141.125 125.949 135.551 1.00 32.54  ? 77  ASN A CB  1 
ATOM 407  C CG  . ASN A 1 103 ? 140.306 124.941 134.784 1.00 32.54  ? 77  ASN A CG  1 
ATOM 408  O OD1 . ASN A 1 103 ? 140.709 124.478 133.720 1.00 32.54  ? 77  ASN A OD1 1 
ATOM 409  N ND2 . ASN A 1 103 ? 139.141 124.602 135.313 1.00 32.54  ? 77  ASN A ND2 1 
ATOM 410  N N   . LEU A 1 104 ? 144.216 125.826 135.121 1.00 32.80  ? 78  LEU A N   1 
ATOM 411  C CA  . LEU A 1 104 ? 145.244 125.562 134.119 1.00 32.80  ? 78  LEU A CA  1 
ATOM 412  C C   . LEU A 1 104 ? 146.380 124.721 134.680 1.00 32.80  ? 78  LEU A C   1 
ATOM 413  O O   . LEU A 1 104 ? 146.982 123.920 133.958 1.00 32.80  ? 78  LEU A O   1 
ATOM 414  C CB  . LEU A 1 104 ? 145.782 126.886 133.588 1.00 32.80  ? 78  LEU A CB  1 
ATOM 415  C CG  . LEU A 1 104 ? 145.215 127.526 132.326 1.00 32.80  ? 78  LEU A CG  1 
ATOM 416  C CD1 . LEU A 1 104 ? 143.735 127.805 132.429 1.00 32.80  ? 78  LEU A CD1 1 
ATOM 417  C CD2 . LEU A 1 104 ? 145.955 128.824 132.156 1.00 32.80  ? 78  LEU A CD2 1 
ATOM 418  N N   . LEU A 1 105 ? 146.689 124.889 135.965 1.00 30.60  ? 79  LEU A N   1 
ATOM 419  C CA  . LEU A 1 105 ? 147.852 124.218 136.526 1.00 30.60  ? 79  LEU A CA  1 
ATOM 420  C C   . LEU A 1 105 ? 147.575 122.753 136.825 1.00 30.60  ? 79  LEU A C   1 
ATOM 421  O O   . LEU A 1 105 ? 148.515 121.988 137.064 1.00 30.60  ? 79  LEU A O   1 
ATOM 422  C CB  . LEU A 1 105 ? 148.313 124.941 137.790 1.00 30.60  ? 79  LEU A CB  1 
ATOM 423  C CG  . LEU A 1 105 ? 148.848 126.360 137.573 1.00 30.60  ? 79  LEU A CG  1 
ATOM 424  C CD1 . LEU A 1 105 ? 149.146 127.030 138.903 1.00 30.60  ? 79  LEU A CD1 1 
ATOM 425  C CD2 . LEU A 1 105 ? 150.078 126.368 136.676 1.00 30.60  ? 79  LEU A CD2 1 
ATOM 426  N N   . VAL A 1 106 ? 146.309 122.337 136.821 1.00 30.52  ? 80  VAL A N   1 
ATOM 427  C CA  . VAL A 1 106 ? 145.962 120.954 137.134 1.00 30.52  ? 80  VAL A CA  1 
ATOM 428  C C   . VAL A 1 106 ? 145.224 120.241 136.012 1.00 30.52  ? 80  VAL A C   1 
ATOM 429  O O   . VAL A 1 106 ? 145.045 119.016 136.114 1.00 30.52  ? 80  VAL A O   1 
ATOM 430  C CB  . VAL A 1 106 ? 145.134 120.848 138.433 1.00 30.52  ? 80  VAL A CB  1 
ATOM 431  C CG1 . VAL A 1 106 ? 145.834 121.521 139.600 1.00 30.52  ? 80  VAL A CG1 1 
ATOM 432  C CG2 . VAL A 1 106 ? 143.750 121.409 138.225 1.00 30.52  ? 80  VAL A CG2 1 
ATOM 433  N N   . ILE A 1 107 ? 144.782 120.945 134.957 1.00 30.36  ? 81  ILE A N   1 
ATOM 434  C CA  . ILE A 1 107 ? 143.901 120.313 133.972 1.00 30.36  ? 81  ILE A CA  1 
ATOM 435  C C   . ILE A 1 107 ? 144.628 119.234 133.173 1.00 30.36  ? 81  ILE A C   1 
ATOM 436  O O   . ILE A 1 107 ? 144.077 118.152 132.930 1.00 30.36  ? 81  ILE A O   1 
ATOM 437  C CB  . ILE A 1 107 ? 143.240 121.378 133.070 1.00 30.36  ? 81  ILE A CB  1 
ATOM 438  C CG1 . ILE A 1 107 ? 142.276 120.727 132.078 1.00 30.36  ? 81  ILE A CG1 1 
ATOM 439  C CG2 . ILE A 1 107 ? 144.260 122.269 132.359 1.00 30.36  ? 81  ILE A CG2 1 
ATOM 440  C CD1 . ILE A 1 107 ? 141.207 121.663 131.586 1.00 30.36  ? 81  ILE A CD1 1 
ATOM 441  N N   . VAL A 1 108 ? 145.898 119.469 132.835 1.00 29.87  ? 82  VAL A N   1 
ATOM 442  C CA  . VAL A 1 108 ? 146.653 118.525 132.018 1.00 29.87  ? 82  VAL A CA  1 
ATOM 443  C C   . VAL A 1 108 ? 146.969 117.264 132.812 1.00 29.87  ? 82  VAL A C   1 
ATOM 444  O O   . VAL A 1 108 ? 146.815 116.141 132.316 1.00 29.87  ? 82  VAL A O   1 
ATOM 445  C CB  . VAL A 1 108 ? 147.928 119.199 131.488 1.00 29.87  ? 82  VAL A CB  1 
ATOM 446  C CG1 . VAL A 1 108 ? 148.638 118.295 130.522 1.00 29.87  ? 82  VAL A CG1 1 
ATOM 447  C CG2 . VAL A 1 108 ? 147.585 120.520 130.830 1.00 29.87  ? 82  VAL A CG2 1 
ATOM 448  N N   . PHE A 1 109 ? 147.372 117.432 134.073 1.00 29.85  ? 83  PHE A N   1 
ATOM 449  C CA  . PHE A 1 109 ? 147.734 116.289 134.902 1.00 29.85  ? 83  PHE A CA  1 
ATOM 450  C C   . PHE A 1 109 ? 146.509 115.479 135.304 1.00 29.85  ? 83  PHE A C   1 
ATOM 451  O O   . PHE A 1 109 ? 146.571 114.244 135.353 1.00 29.85  ? 83  PHE A O   1 
ATOM 452  C CB  . PHE A 1 109 ? 148.498 116.764 136.134 1.00 29.85  ? 83  PHE A CB  1 
ATOM 453  C CG  . PHE A 1 109 ? 149.685 117.620 135.811 1.00 29.85  ? 83  PHE A CG  1 
ATOM 454  C CD1 . PHE A 1 109 ? 150.859 117.052 135.344 1.00 29.85  ? 83  PHE A CD1 1 
ATOM 455  C CD2 . PHE A 1 109 ? 149.624 118.997 135.961 1.00 29.85  ? 83  PHE A CD2 1 
ATOM 456  C CE1 . PHE A 1 109 ? 151.953 117.843 135.041 1.00 29.85  ? 83  PHE A CE1 1 
ATOM 457  C CE2 . PHE A 1 109 ? 150.714 119.793 135.657 1.00 29.85  ? 83  PHE A CE2 1 
ATOM 458  C CZ  . PHE A 1 109 ? 151.879 119.214 135.198 1.00 29.85  ? 83  PHE A CZ  1 
ATOM 459  N N   . VAL A 1 110 ? 145.387 116.151 135.587 1.00 29.65  ? 84  VAL A N   1 
ATOM 460  C CA  . VAL A 1 110 ? 144.148 115.445 135.905 1.00 29.65  ? 84  VAL A CA  1 
ATOM 461  C C   . VAL A 1 110 ? 143.651 114.672 134.691 1.00 29.65  ? 84  VAL A C   1 
ATOM 462  O O   . VAL A 1 110 ? 143.251 113.506 134.806 1.00 29.65  ? 84  VAL A O   1 
ATOM 463  C CB  . VAL A 1 110 ? 143.093 116.440 136.431 1.00 29.65  ? 84  VAL A CB  1 
ATOM 464  C CG1 . VAL A 1 110 ? 141.689 115.875 136.331 1.00 29.65  ? 84  VAL A CG1 1 
ATOM 465  C CG2 . VAL A 1 110 ? 143.389 116.798 137.871 1.00 29.65  ? 84  VAL A CG2 1 
ATOM 466  N N   . SER A 1 111 ? 143.724 115.287 133.504 1.00 31.31  ? 85  SER A N   1 
ATOM 467  C CA  . SER A 1 111 ? 143.282 114.628 132.280 1.00 31.31  ? 85  SER A CA  1 
ATOM 468  C C   . SER A 1 111 ? 144.157 113.430 131.935 1.00 31.31  ? 85  SER A C   1 
ATOM 469  O O   . SER A 1 111 ? 143.658 112.412 131.444 1.00 31.31  ? 85  SER A O   1 
ATOM 470  C CB  . SER A 1 111 ? 143.270 115.635 131.136 1.00 31.31  ? 85  SER A CB  1 
ATOM 471  O OG  . SER A 1 111 ? 144.567 116.150 130.920 1.00 31.31  ? 85  SER A OG  1 
ATOM 472  N N   . TYR A 1 112 ? 145.468 113.527 132.181 1.00 28.94  ? 86  TYR A N   1 
ATOM 473  C CA  . TYR A 1 112 ? 146.328 112.376 131.920 1.00 28.94  ? 86  TYR A CA  1 
ATOM 474  C C   . TYR A 1 112 ? 146.103 111.262 132.934 1.00 28.94  ? 86  TYR A C   1 
ATOM 475  O O   . TYR A 1 112 ? 145.858 110.111 132.555 1.00 28.94  ? 86  TYR A O   1 
ATOM 476  C CB  . TYR A 1 112 ? 147.804 112.772 131.918 1.00 28.94  ? 86  TYR A CB  1 
ATOM 477  C CG  . TYR A 1 112 ? 148.697 111.552 131.922 1.00 28.94  ? 86  TYR A CG  1 
ATOM 478  C CD1 . TYR A 1 112 ? 148.721 110.683 130.836 1.00 28.94  ? 86  TYR A CD1 1 
ATOM 479  C CD2 . TYR A 1 112 ? 149.491 111.248 133.018 1.00 28.94  ? 86  TYR A CD2 1 
ATOM 480  C CE1 . TYR A 1 112 ? 149.514 109.557 130.842 1.00 28.94  ? 86  TYR A CE1 1 
ATOM 481  C CE2 . TYR A 1 112 ? 150.286 110.122 133.030 1.00 28.94  ? 86  TYR A CE2 1 
ATOM 482  C CZ  . TYR A 1 112 ? 150.292 109.284 131.940 1.00 28.94  ? 86  TYR A CZ  1 
ATOM 483  O OH  . TYR A 1 112 ? 151.086 108.166 131.947 1.00 28.94  ? 86  TYR A OH  1 
ATOM 484  N N   . PHE A 1 113 ? 146.200 111.573 134.226 1.00 33.01  ? 87  PHE A N   1 
ATOM 485  C CA  . PHE A 1 113 ? 146.210 110.532 135.243 1.00 33.01  ? 87  PHE A CA  1 
ATOM 486  C C   . PHE A 1 113 ? 144.835 109.955 135.535 1.00 33.01  ? 87  PHE A C   1 
ATOM 487  O O   . PHE A 1 113 ? 144.748 108.802 135.968 1.00 33.01  ? 87  PHE A O   1 
ATOM 488  C CB  . PHE A 1 113 ? 146.831 111.071 136.532 1.00 33.01  ? 87  PHE A CB  1 
ATOM 489  C CG  . PHE A 1 113 ? 148.328 111.065 136.517 1.00 33.01  ? 87  PHE A CG  1 
ATOM 490  C CD1 . PHE A 1 113 ? 149.028 109.876 136.631 1.00 33.01  ? 87  PHE A CD1 1 
ATOM 491  C CD2 . PHE A 1 113 ? 149.035 112.244 136.365 1.00 33.01  ? 87  PHE A CD2 1 
ATOM 492  C CE1 . PHE A 1 113 ? 150.405 109.866 136.606 1.00 33.01  ? 87  PHE A CE1 1 
ATOM 493  C CE2 . PHE A 1 113 ? 150.411 112.239 136.337 1.00 33.01  ? 87  PHE A CE2 1 
ATOM 494  C CZ  . PHE A 1 113 ? 151.096 111.049 136.459 1.00 33.01  ? 87  PHE A CZ  1 
ATOM 495  N N   . GLY A 1 114 ? 143.764 110.710 135.302 1.00 33.46  ? 88  GLY A N   1 
ATOM 496  C CA  . GLY A 1 114 ? 142.429 110.200 135.529 1.00 33.46  ? 88  GLY A CA  1 
ATOM 497  C C   . GLY A 1 114 ? 141.854 109.361 134.418 1.00 33.46  ? 88  GLY A C   1 
ATOM 498  O O   . GLY A 1 114 ? 140.758 108.820 134.572 1.00 33.46  ? 88  GLY A O   1 
ATOM 499  N N   . SER A 1 115 ? 142.561 109.236 133.295 1.00 37.25  ? 89  SER A N   1 
ATOM 500  C CA  . SER A 1 115 ? 142.060 108.414 132.200 1.00 37.25  ? 89  SER A CA  1 
ATOM 501  C C   . SER A 1 115 ? 142.225 106.931 132.493 1.00 37.25  ? 89  SER A C   1 
ATOM 502  O O   . SER A 1 115 ? 141.571 106.097 131.859 1.00 37.25  ? 89  SER A O   1 
ATOM 503  C CB  . SER A 1 115 ? 142.774 108.777 130.901 1.00 37.25  ? 89  SER A CB  1 
ATOM 504  O OG  . SER A 1 115 ? 144.140 108.405 130.950 1.00 37.25  ? 89  SER A OG  1 
ATOM 505  N N   . LYS A 1 116 ? 143.098 106.582 133.438 1.00 38.32  ? 90  LYS A N   1 
ATOM 506  C CA  . LYS A 1 116 ? 143.299 105.196 133.829 1.00 38.32  ? 90  LYS A CA  1 
ATOM 507  C C   . LYS A 1 116 ? 142.590 104.828 135.123 1.00 38.32  ? 90  LYS A C   1 
ATOM 508  O O   . LYS A 1 116 ? 142.524 103.641 135.458 1.00 38.32  ? 90  LYS A O   1 
ATOM 509  C CB  . LYS A 1 116 ? 144.795 104.901 133.978 1.00 38.32  ? 90  LYS A CB  1 
ATOM 510  C CG  . LYS A 1 116 ? 145.615 105.203 132.734 1.00 38.32  ? 90  LYS A CG  1 
ATOM 511  C CD  . LYS A 1 116 ? 145.131 104.393 131.541 1.00 38.32  ? 90  LYS A CD  1 
ATOM 512  C CE  . LYS A 1 116 ? 145.398 105.118 130.232 1.00 38.32  ? 90  LYS A CE  1 
ATOM 513  N NZ  . LYS A 1 116 ? 144.194 105.841 129.741 1.00 38.32  ? 90  LYS A NZ  1 
ATOM 514  N N   . LEU A 1 117 ? 142.065 105.807 135.851 1.00 36.69  ? 91  LEU A N   1 
ATOM 515  C CA  . LEU A 1 117 ? 141.405 105.562 137.122 1.00 36.69  ? 91  LEU A CA  1 
ATOM 516  C C   . LEU A 1 117 ? 139.895 105.478 136.914 1.00 36.69  ? 91  LEU A C   1 
ATOM 517  O O   . LEU A 1 117 ? 139.399 105.437 135.786 1.00 36.69  ? 91  LEU A O   1 
ATOM 518  C CB  . LEU A 1 117 ? 141.768 106.652 138.125 1.00 36.69  ? 91  LEU A CB  1 
ATOM 519  C CG  . LEU A 1 117 ? 143.252 106.955 138.308 1.00 36.69  ? 91  LEU A CG  1 
ATOM 520  C CD1 . LEU A 1 117 ? 143.445 108.099 139.289 1.00 36.69  ? 91  LEU A CD1 1 
ATOM 521  C CD2 . LEU A 1 117 ? 143.999 105.717 138.760 1.00 36.69  ? 91  LEU A CD2 1 
ATOM 522  N N   . HIS A 1 118 ? 139.152 105.451 138.014 1.00 38.65  ? 92  HIS A N   1 
ATOM 523  C CA  . HIS A 1 118 ? 137.692 105.453 137.994 1.00 38.65  ? 92  HIS A CA  1 
ATOM 524  C C   . HIS A 1 118 ? 137.222 106.842 137.586 1.00 38.65  ? 92  HIS A C   1 
ATOM 525  O O   . HIS A 1 118 ? 137.123 107.741 138.420 1.00 38.65  ? 92  HIS A O   1 
ATOM 526  C CB  . HIS A 1 118 ? 137.165 105.067 139.371 1.00 38.65  ? 92  HIS A CB  1 
ATOM 527  C CG  . HIS A 1 118 ? 135.754 104.572 139.376 1.00 38.65  ? 92  HIS A CG  1 
ATOM 528  N ND1 . HIS A 1 118 ? 134.705 105.298 138.858 1.00 38.65  ? 92  HIS A ND1 1 
ATOM 529  C CD2 . HIS A 1 118 ? 135.217 103.429 139.861 1.00 38.65  ? 92  HIS A CD2 1 
ATOM 530  C CE1 . HIS A 1 118 ? 133.583 104.619 139.013 1.00 38.65  ? 92  HIS A CE1 1 
ATOM 531  N NE2 . HIS A 1 118 ? 133.866 103.481 139.620 1.00 38.65  ? 92  HIS A NE2 1 
ATOM 532  N N   . ARG A 1 119 ? 136.943 107.017 136.291 1.00 33.59  ? 93  ARG A N   1 
ATOM 533  C CA  . ARG A 1 119 ? 136.599 108.335 135.752 1.00 33.59  ? 93  ARG A CA  1 
ATOM 534  C C   . ARG A 1 119 ? 135.328 108.962 136.335 1.00 33.59  ? 93  ARG A C   1 
ATOM 535  O O   . ARG A 1 119 ? 135.381 110.159 136.672 1.00 33.59  ? 93  ARG A O   1 
ATOM 536  C CB  . ARG A 1 119 ? 136.535 108.266 134.220 1.00 33.59  ? 93  ARG A CB  1 
ATOM 537  C CG  . ARG A 1 119 ? 137.715 107.581 133.568 1.00 33.59  ? 93  ARG A CG  1 
ATOM 538  C CD  . ARG A 1 119 ? 137.639 107.664 132.055 1.00 33.59  ? 93  ARG A CD  1 
ATOM 539  N NE  . ARG A 1 119 ? 138.300 106.527 131.427 1.00 33.59  ? 93  ARG A NE  1 
ATOM 540  C CZ  . ARG A 1 119 ? 138.053 106.098 130.197 1.00 33.59  ? 93  ARG A CZ  1 
ATOM 541  N NH1 . ARG A 1 119 ? 137.176 106.704 129.417 1.00 33.59  ? 93  ARG A NH1 1 
ATOM 542  N NH2 . ARG A 1 119 ? 138.707 105.036 129.736 1.00 33.59  ? 93  ARG A NH2 1 
ATOM 543  N N   . PRO A 1 120 ? 134.171 108.264 136.470 1.00 35.93  ? 94  PRO A N   1 
ATOM 544  C CA  . PRO A 1 120 ? 133.028 108.931 137.126 1.00 35.93  ? 94  PRO A CA  1 
ATOM 545  C C   . PRO A 1 120 ? 133.275 109.288 138.578 1.00 35.93  ? 94  PRO A C   1 
ATOM 546  O O   . PRO A 1 120 ? 132.747 110.298 139.055 1.00 35.93  ? 94  PRO A O   1 
ATOM 547  C CB  . PRO A 1 120 ? 131.891 107.908 136.987 1.00 35.93  ? 94  PRO A CB  1 
ATOM 548  C CG  . PRO A 1 120 ? 132.282 107.050 135.891 1.00 35.93  ? 94  PRO A CG  1 
ATOM 549  C CD  . PRO A 1 120 ? 133.751 106.924 136.006 1.00 35.93  ? 94  PRO A CD  1 
ATOM 550  N N   . LYS A 1 121 ? 134.093 108.500 139.282 1.00 33.50  ? 95  LYS A N   1 
ATOM 551  C CA  . LYS A 1 121 ? 134.450 108.827 140.658 1.00 33.50  ? 95  LYS A CA  1 
ATOM 552  C C   . LYS A 1 121 ? 135.253 110.120 140.734 1.00 33.50  ? 95  LYS A C   1 
ATOM 553  O O   . LYS A 1 121 ? 135.004 110.952 141.610 1.00 33.50  ? 95  LYS A O   1 
ATOM 554  C CB  . LYS A 1 121 ? 135.225 107.669 141.282 1.00 33.50  ? 95  LYS A CB  1 
ATOM 555  C CG  . LYS A 1 121 ? 135.149 107.625 142.794 1.00 33.50  ? 95  LYS A CG  1 
ATOM 556  C CD  . LYS A 1 121 ? 135.594 106.280 143.327 1.00 33.50  ? 95  LYS A CD  1 
ATOM 557  C CE  . LYS A 1 121 ? 134.566 105.208 143.021 1.00 33.50  ? 95  LYS A CE  1 
ATOM 558  N NZ  . LYS A 1 121 ? 133.375 105.323 143.906 1.00 33.50  ? 95  LYS A NZ  1 
ATOM 559  N N   . LEU A 1 122 ? 136.190 110.328 139.804 1.00 32.11  ? 96  LEU A N   1 
ATOM 560  C CA  . LEU A 1 122 ? 136.936 111.583 139.786 1.00 32.11  ? 96  LEU A CA  1 
ATOM 561  C C   . LEU A 1 122 ? 136.079 112.764 139.346 1.00 32.11  ? 96  LEU A C   1 
ATOM 562  O O   . LEU A 1 122 ? 136.295 113.881 139.829 1.00 32.11  ? 96  LEU A O   1 
ATOM 563  C CB  . LEU A 1 122 ? 138.179 111.473 138.901 1.00 32.11  ? 96  LEU A CB  1 
ATOM 564  C CG  . LEU A 1 122 ? 139.489 110.964 139.520 1.00 32.11  ? 96  LEU A CG  1 
ATOM 565  C CD1 . LEU A 1 122 ? 139.483 109.488 139.849 1.00 32.11  ? 96  LEU A CD1 1 
ATOM 566  C CD2 . LEU A 1 122 ? 140.650 111.293 138.607 1.00 32.11  ? 96  LEU A CD2 1 
ATOM 567  N N   . ILE A 1 123 ? 135.105 112.551 138.452 1.00 31.21  ? 97  ILE A N   1 
ATOM 568  C CA  . ILE A 1 123 ? 134.196 113.645 138.099 1.00 31.21  ? 97  ILE A CA  1 
ATOM 569  C C   . ILE A 1 123 ? 133.318 114.017 139.292 1.00 31.21  ? 97  ILE A C   1 
ATOM 570  O O   . ILE A 1 123 ? 133.053 115.201 139.543 1.00 31.21  ? 97  ILE A O   1 
ATOM 571  C CB  . ILE A 1 123 ? 133.353 113.281 136.862 1.00 31.21  ? 97  ILE A CB  1 
ATOM 572  C CG1 . ILE A 1 123 ? 134.245 112.992 135.665 1.00 31.21  ? 97  ILE A CG1 1 
ATOM 573  C CG2 . ILE A 1 123 ? 132.470 114.433 136.454 1.00 31.21  ? 97  ILE A CG2 1 
ATOM 574  C CD1 . ILE A 1 123 ? 133.516 112.325 134.539 1.00 31.21  ? 97  ILE A CD1 1 
ATOM 575  N N   . GLY A 1 124 ? 132.883 113.019 140.064 1.00 32.34  ? 98  GLY A N   1 
ATOM 576  C CA  . GLY A 1 124 ? 132.130 113.302 141.276 1.00 32.34  ? 98  GLY A CA  1 
ATOM 577  C C   . GLY A 1 124 ? 132.961 113.992 142.341 1.00 32.34  ? 98  GLY A C   1 
ATOM 578  O O   . GLY A 1 124 ? 132.462 114.857 143.063 1.00 32.34  ? 98  GLY A O   1 
ATOM 579  N N   . ILE A 1 125 ? 134.239 113.618 142.448 1.00 29.77  ? 99  ILE A N   1 
ATOM 580  C CA  . ILE A 1 125 ? 135.157 114.289 143.366 1.00 29.77  ? 99  ILE A CA  1 
ATOM 581  C C   . ILE A 1 125 ? 135.351 115.744 142.956 1.00 29.77  ? 99  ILE A C   1 
ATOM 582  O O   . ILE A 1 125 ? 135.354 116.644 143.803 1.00 29.77  ? 99  ILE A O   1 
ATOM 583  C CB  . ILE A 1 125 ? 136.490 113.516 143.436 1.00 29.77  ? 99  ILE A CB  1 
ATOM 584  C CG1 . ILE A 1 125 ? 136.324 112.250 144.272 1.00 29.77  ? 99  ILE A CG1 1 
ATOM 585  C CG2 . ILE A 1 125 ? 137.606 114.350 144.035 1.00 29.77  ? 99  ILE A CG2 1 
ATOM 586  C CD1 . ILE A 1 125 ? 137.416 111.239 144.052 1.00 29.77  ? 99  ILE A CD1 1 
ATOM 587  N N   . GLY A 1 126 ? 135.466 116.004 141.651 1.00 30.24  ? 100 GLY A N   1 
ATOM 588  C CA  . GLY A 1 126 ? 135.580 117.379 141.181 1.00 30.24  ? 100 GLY A CA  1 
ATOM 589  C C   . GLY A 1 126 ? 134.327 118.203 141.419 1.00 30.24  ? 100 GLY A C   1 
ATOM 590  O O   . GLY A 1 126 ? 134.407 119.381 141.776 1.00 30.24  ? 100 GLY A O   1 
ATOM 591  N N   . CYS A 1 127 ? 133.154 117.594 141.233 1.00 27.98  ? 101 CYS A N   1 
ATOM 592  C CA  . CYS A 1 127 ? 131.903 118.296 141.512 1.00 27.98  ? 101 CYS A CA  1 
ATOM 593  C C   . CYS A 1 127 ? 131.742 118.571 143.005 1.00 27.98  ? 101 CYS A C   1 
ATOM 594  O O   . CYS A 1 127 ? 131.260 119.641 143.400 1.00 27.98  ? 101 CYS A O   1 
ATOM 595  C CB  . CYS A 1 127 ? 130.723 117.493 140.974 1.00 27.98  ? 101 CYS A CB  1 
ATOM 596  S SG  . CYS A 1 127 ? 130.579 117.530 139.185 1.00 27.98  ? 101 CYS A SG  1 
ATOM 597  N N   . PHE A 1 128 ? 132.176 117.631 143.847 1.00 29.60  ? 102 PHE A N   1 
ATOM 598  C CA  . PHE A 1 128 ? 132.213 117.861 145.287 1.00 29.60  ? 102 PHE A CA  1 
ATOM 599  C C   . PHE A 1 128 ? 133.175 118.988 145.646 1.00 29.60  ? 102 PHE A C   1 
ATOM 600  O O   . PHE A 1 128 ? 132.881 119.806 146.522 1.00 29.60  ? 102 PHE A O   1 
ATOM 601  C CB  . PHE A 1 128 ? 132.611 116.569 145.995 1.00 29.60  ? 102 PHE A CB  1 
ATOM 602  C CG  . PHE A 1 128 ? 132.239 116.525 147.444 1.00 29.60  ? 102 PHE A CG  1 
ATOM 603  C CD1 . PHE A 1 128 ? 130.912 116.570 147.833 1.00 29.60  ? 102 PHE A CD1 1 
ATOM 604  C CD2 . PHE A 1 128 ? 133.216 116.403 148.416 1.00 29.60  ? 102 PHE A CD2 1 
ATOM 605  C CE1 . PHE A 1 128 ? 130.566 116.518 149.167 1.00 29.60  ? 102 PHE A CE1 1 
ATOM 606  C CE2 . PHE A 1 128 ? 132.878 116.348 149.750 1.00 29.60  ? 102 PHE A CE2 1 
ATOM 607  C CZ  . PHE A 1 128 ? 131.552 116.406 150.126 1.00 29.60  ? 102 PHE A CZ  1 
ATOM 608  N N   . ILE A 1 129 ? 134.321 119.051 144.964 1.00 29.78  ? 103 ILE A N   1 
ATOM 609  C CA  . ILE A 1 129 ? 135.331 120.071 145.237 1.00 29.78  ? 103 ILE A CA  1 
ATOM 610  C C   . ILE A 1 129 ? 134.822 121.458 144.858 1.00 29.78  ? 103 ILE A C   1 
ATOM 611  O O   . ILE A 1 129 ? 135.004 122.424 145.610 1.00 29.78  ? 103 ILE A O   1 
ATOM 612  C CB  . ILE A 1 129 ? 136.643 119.703 144.515 1.00 29.78  ? 103 ILE A CB  1 
ATOM 613  C CG1 . ILE A 1 129 ? 137.427 118.679 145.336 1.00 29.78  ? 103 ILE A CG1 1 
ATOM 614  C CG2 . ILE A 1 129 ? 137.516 120.913 144.248 1.00 29.78  ? 103 ILE A CG2 1 
ATOM 615  C CD1 . ILE A 1 129 ? 138.533 118.002 144.570 1.00 29.78  ? 103 ILE A CD1 1 
ATOM 616  N N   . MET A 1 130 ? 134.140 121.579 143.713 1.00 29.03  ? 104 MET A N   1 
ATOM 617  C CA  . MET A 1 130 ? 133.595 122.885 143.344 1.00 29.03  ? 104 MET A CA  1 
ATOM 618  C C   . MET A 1 130 ? 132.387 123.243 144.204 1.00 29.03  ? 104 MET A C   1 
ATOM 619  O O   . MET A 1 130 ? 132.107 124.427 144.420 1.00 29.03  ? 104 MET A O   1 
ATOM 620  C CB  . MET A 1 130 ? 133.246 122.948 141.855 1.00 29.03  ? 104 MET A CB  1 
ATOM 621  C CG  . MET A 1 130 ? 132.190 121.989 141.375 1.00 29.03  ? 104 MET A CG  1 
ATOM 622  S SD  . MET A 1 130 ? 131.940 122.030 139.587 1.00 29.03  ? 104 MET A SD  1 
ATOM 623  C CE  . MET A 1 130 ? 131.983 123.789 139.276 1.00 29.03  ? 104 MET A CE  1 
ATOM 624  N N   . GLY A 1 131 ? 131.693 122.239 144.749 1.00 30.32  ? 105 GLY A N   1 
ATOM 625  C CA  . GLY A 1 131 ? 130.679 122.521 145.755 1.00 30.32  ? 105 GLY A CA  1 
ATOM 626  C C   . GLY A 1 131 ? 131.252 123.071 147.048 1.00 30.32  ? 105 GLY A C   1 
ATOM 627  O O   . GLY A 1 131 ? 130.707 124.018 147.624 1.00 30.32  ? 105 GLY A O   1 
ATOM 628  N N   . ILE A 1 132 ? 132.355 122.483 147.521 1.00 29.47  ? 106 ILE A N   1 
ATOM 629  C CA  . ILE A 1 132 ? 133.037 122.988 148.713 1.00 29.47  ? 106 ILE A CA  1 
ATOM 630  C C   . ILE A 1 132 ? 133.580 124.390 148.463 1.00 29.47  ? 106 ILE A C   1 
ATOM 631  O O   . ILE A 1 132 ? 133.531 125.254 149.345 1.00 29.47  ? 106 ILE A O   1 
ATOM 632  C CB  . ILE A 1 132 ? 134.143 122.009 149.153 1.00 29.47  ? 106 ILE A CB  1 
ATOM 633  C CG1 . ILE A 1 132 ? 133.545 120.670 149.559 1.00 29.47  ? 106 ILE A CG1 1 
ATOM 634  C CG2 . ILE A 1 132 ? 134.948 122.541 150.323 1.00 29.47  ? 106 ILE A CG2 1 
ATOM 635  C CD1 . ILE A 1 132 ? 134.558 119.566 149.590 1.00 29.47  ? 106 ILE A CD1 1 
ATOM 636  N N   . GLY A 1 133 ? 134.067 124.648 147.248 1.00 30.40  ? 107 GLY A N   1 
ATOM 637  C CA  . GLY A 1 133 ? 134.490 125.996 146.897 1.00 30.40  ? 107 GLY A CA  1 
ATOM 638  C C   . GLY A 1 133 ? 133.344 126.992 146.873 1.00 30.40  ? 107 GLY A C   1 
ATOM 639  O O   . GLY A 1 133 ? 133.499 128.139 147.299 1.00 30.40  ? 107 GLY A O   1 
ATOM 640  N N   . GLY A 1 134 ? 132.175 126.560 146.393 1.00 30.63  ? 108 GLY A N   1 
ATOM 641  C CA  . GLY A 1 134 ? 131.007 127.428 146.410 1.00 30.63  ? 108 GLY A CA  1 
ATOM 642  C C   . GLY A 1 134 ? 130.517 127.741 147.812 1.00 30.63  ? 108 GLY A C   1 
ATOM 643  O O   . GLY A 1 134 ? 130.060 128.853 148.083 1.00 30.63  ? 108 GLY A O   1 
ATOM 644  N N   . VAL A 1 135 ? 130.591 126.764 148.717 1.00 31.37  ? 109 VAL A N   1 
ATOM 645  C CA  . VAL A 1 135 ? 130.243 127.026 150.114 1.00 31.37  ? 109 VAL A CA  1 
ATOM 646  C C   . VAL A 1 135 ? 131.284 127.934 150.770 1.00 31.37  ? 109 VAL A C   1 
ATOM 647  O O   . VAL A 1 135 ? 130.941 128.866 151.512 1.00 31.37  ? 109 VAL A O   1 
ATOM 648  C CB  . VAL A 1 135 ? 130.072 125.699 150.877 1.00 31.37  ? 109 VAL A CB  1 
ATOM 649  C CG1 . VAL A 1 135 ? 129.742 125.951 152.334 1.00 31.37  ? 109 VAL A CG1 1 
ATOM 650  C CG2 . VAL A 1 135 ? 128.967 124.879 150.255 1.00 31.37  ? 109 VAL A CG2 1 
ATOM 651  N N   . LEU A 1 136 ? 132.567 127.692 150.485 1.00 32.49  ? 110 LEU A N   1 
ATOM 652  C CA  . LEU A 1 136 ? 133.648 128.466 151.085 1.00 32.49  ? 110 LEU A CA  1 
ATOM 653  C C   . LEU A 1 136 ? 133.663 129.903 150.586 1.00 32.49  ? 110 LEU A C   1 
ATOM 654  O O   . LEU A 1 136 ? 134.155 130.791 151.285 1.00 32.49  ? 110 LEU A O   1 
ATOM 655  C CB  . LEU A 1 136 ? 134.983 127.778 150.791 1.00 32.49  ? 110 LEU A CB  1 
ATOM 656  C CG  . LEU A 1 136 ? 136.299 128.332 151.340 1.00 32.49  ? 110 LEU A CG  1 
ATOM 657  C CD1 . LEU A 1 136 ? 136.338 128.243 152.853 1.00 32.49  ? 110 LEU A CD1 1 
ATOM 658  C CD2 . LEU A 1 136 ? 137.468 127.591 150.727 1.00 32.49  ? 110 LEU A CD2 1 
ATOM 659  N N   . THR A 1 137 ? 133.136 130.153 149.386 1.00 30.56  ? 111 THR A N   1 
ATOM 660  C CA  . THR A 1 137 ? 133.019 131.528 148.909 1.00 30.56  ? 111 THR A CA  1 
ATOM 661  C C   . THR A 1 137 ? 131.980 132.301 149.715 1.00 30.56  ? 111 THR A C   1 
ATOM 662  O O   . THR A 1 137 ? 132.182 133.475 150.044 1.00 30.56  ? 111 THR A O   1 
ATOM 663  C CB  . THR A 1 137 ? 132.661 131.533 147.425 1.00 30.56  ? 111 THR A CB  1 
ATOM 664  O OG1 . THR A 1 137 ? 133.575 130.694 146.714 1.00 30.56  ? 111 THR A OG1 1 
ATOM 665  C CG2 . THR A 1 137 ? 132.761 132.931 146.863 1.00 30.56  ? 111 THR A CG2 1 
ATOM 666  N N   . ALA A 1 138 ? 130.869 131.650 150.060 1.00 33.26  ? 112 ALA A N   1 
ATOM 667  C CA  . ALA A 1 138 ? 129.822 132.291 150.843 1.00 33.26  ? 112 ALA A CA  1 
ATOM 668  C C   . ALA A 1 138 ? 130.129 132.320 152.330 1.00 33.26  ? 112 ALA A C   1 
ATOM 669  O O   . ALA A 1 138 ? 129.448 133.036 153.070 1.00 33.26  ? 112 ALA A O   1 
ATOM 670  C CB  . ALA A 1 138 ? 128.491 131.577 150.622 1.00 33.26  ? 112 ALA A CB  1 
ATOM 671  N N   . LEU A 1 139 ? 131.107 131.535 152.779 1.00 33.16  ? 113 LEU A N   1 
ATOM 672  C CA  . LEU A 1 139 ? 131.462 131.529 154.197 1.00 33.16  ? 113 LEU A CA  1 
ATOM 673  C C   . LEU A 1 139 ? 131.998 132.850 154.766 1.00 33.16  ? 113 LEU A C   1 
ATOM 674  O O   . LEU A 1 139 ? 131.872 133.025 155.988 1.00 33.16  ? 113 LEU A O   1 
ATOM 675  C CB  . LEU A 1 139 ? 132.468 130.398 154.473 1.00 33.16  ? 113 LEU A CB  1 
ATOM 676  C CG  . LEU A 1 139 ? 131.938 129.076 155.025 1.00 33.16  ? 113 LEU A CG  1 
ATOM 677  C CD1 . LEU A 1 139 ? 133.041 128.034 155.042 1.00 33.16  ? 113 LEU A CD1 1 
ATOM 678  C CD2 . LEU A 1 139 ? 131.346 129.257 156.406 1.00 33.16  ? 113 LEU A CD2 1 
ATOM 679  N N   . PRO A 1 140 ? 132.633 133.771 154.004 1.00 34.70  ? 114 PRO A N   1 
ATOM 680  C CA  . PRO A 1 140 ? 132.938 135.097 154.574 1.00 34.70  ? 114 PRO A CA  1 
ATOM 681  C C   . PRO A 1 140 ? 131.755 135.869 155.123 1.00 34.70  ? 114 PRO A C   1 
ATOM 682  O O   . PRO A 1 140 ? 131.928 136.616 156.090 1.00 34.70  ? 114 PRO A O   1 
ATOM 683  C CB  . PRO A 1 140 ? 133.531 135.846 153.379 1.00 34.70  ? 114 PRO A CB  1 
ATOM 684  C CG  . PRO A 1 140 ? 134.069 134.807 152.482 1.00 34.70  ? 114 PRO A CG  1 
ATOM 685  C CD  . PRO A 1 140 ? 133.685 133.460 153.025 1.00 34.70  ? 114 PRO A CD  1 
ATOM 686  N N   . HIS A 1 141 ? 130.571 135.739 154.522 1.00 37.00  ? 115 HIS A N   1 
ATOM 687  C CA  . HIS A 1 141 ? 129.411 136.476 155.012 1.00 37.00  ? 115 HIS A CA  1 
ATOM 688  C C   . HIS A 1 141 ? 128.980 136.001 156.389 1.00 37.00  ? 115 HIS A C   1 
ATOM 689  O O   . HIS A 1 141 ? 128.575 136.817 157.226 1.00 37.00  ? 115 HIS A O   1 
ATOM 690  C CB  . HIS A 1 141 ? 128.240 136.343 154.041 1.00 37.00  ? 115 HIS A CB  1 
ATOM 691  C CG  . HIS A 1 141 ? 126.912 136.636 154.666 1.00 37.00  ? 115 HIS A CG  1 
ATOM 692  N ND1 . HIS A 1 141 ? 126.038 135.647 155.057 1.00 37.00  ? 115 HIS A ND1 1 
ATOM 693  C CD2 . HIS A 1 141 ? 126.330 137.810 155.008 1.00 37.00  ? 115 HIS A CD2 1 
ATOM 694  C CE1 . HIS A 1 141 ? 124.964 136.199 155.592 1.00 37.00  ? 115 HIS A CE1 1 
ATOM 695  N NE2 . HIS A 1 141 ? 125.116 137.510 155.573 1.00 37.00  ? 115 HIS A NE2 1 
ATOM 696  N N   . PHE A 1 142 ? 129.103 134.699 156.648 1.00 34.83  ? 116 PHE A N   1 
ATOM 697  C CA  . PHE A 1 142 ? 128.464 134.103 157.810 1.00 34.83  ? 116 PHE A CA  1 
ATOM 698  C C   . PHE A 1 142 ? 129.127 134.518 159.106 1.00 34.83  ? 116 PHE A C   1 
ATOM 699  O O   . PHE A 1 142 ? 128.472 134.512 160.145 1.00 34.83  ? 116 PHE A O   1 
ATOM 700  C CB  . PHE A 1 142 ? 128.466 132.585 157.689 1.00 34.83  ? 116 PHE A CB  1 
ATOM 701  C CG  . PHE A 1 142 ? 127.302 132.051 156.923 1.00 34.83  ? 116 PHE A CG  1 
ATOM 702  C CD1 . PHE A 1 142 ? 126.029 132.100 157.462 1.00 34.83  ? 116 PHE A CD1 1 
ATOM 703  C CD2 . PHE A 1 142 ? 127.476 131.517 155.660 1.00 34.83  ? 116 PHE A CD2 1 
ATOM 704  C CE1 . PHE A 1 142 ? 124.953 131.618 156.761 1.00 34.83  ? 116 PHE A CE1 1 
ATOM 705  C CE2 . PHE A 1 142 ? 126.405 131.032 154.953 1.00 34.83  ? 116 PHE A CE2 1 
ATOM 706  C CZ  . PHE A 1 142 ? 125.140 131.082 155.504 1.00 34.83  ? 116 PHE A CZ  1 
ATOM 707  N N   . PHE A 1 143 ? 130.405 134.879 159.068 1.00 32.25  ? 117 PHE A N   1 
ATOM 708  C CA  . PHE A 1 143 ? 131.174 135.285 160.243 1.00 32.25  ? 117 PHE A CA  1 
ATOM 709  C C   . PHE A 1 143 ? 132.050 136.509 159.972 1.00 32.25  ? 117 PHE A C   1 
ATOM 710  O O   . PHE A 1 143 ? 133.227 136.564 160.322 1.00 32.25  ? 117 PHE A O   1 
ATOM 711  C CB  . PHE A 1 143 ? 131.877 134.061 160.859 1.00 32.25  ? 117 PHE A CB  1 
ATOM 712  C CG  . PHE A 1 143 ? 132.870 133.349 159.970 1.00 32.25  ? 117 PHE A CG  1 
ATOM 713  C CD1 . PHE A 1 143 ? 132.430 132.307 159.173 1.00 32.25  ? 117 PHE A CD1 1 
ATOM 714  C CD2 . PHE A 1 143 ? 134.204 133.673 159.933 1.00 32.25  ? 117 PHE A CD2 1 
ATOM 715  C CE1 . PHE A 1 143 ? 133.300 131.602 158.375 1.00 32.25  ? 117 PHE A CE1 1 
ATOM 716  C CE2 . PHE A 1 143 ? 135.074 132.983 159.109 1.00 32.25  ? 117 PHE A CE2 1 
ATOM 717  C CZ  . PHE A 1 143 ? 134.614 131.947 158.332 1.00 32.25  ? 117 PHE A CZ  1 
ATOM 718  N N   . MET A 1 144 ? 131.444 137.557 159.406 1.00 33.03  ? 118 MET A N   1 
ATOM 719  C CA  . MET A 1 144 ? 132.062 138.876 159.335 1.00 33.03  ? 118 MET A CA  1 
ATOM 720  C C   . MET A 1 144 ? 131.300 139.973 160.064 1.00 33.03  ? 118 MET A C   1 
ATOM 721  O O   . MET A 1 144 ? 131.892 141.022 160.341 1.00 33.03  ? 118 MET A O   1 
ATOM 722  C CB  . MET A 1 144 ? 132.234 139.325 157.877 1.00 33.03  ? 118 MET A CB  1 
ATOM 723  C CG  . MET A 1 144 ? 133.621 139.137 157.315 1.00 33.03  ? 118 MET A CG  1 
ATOM 724  S SD  . MET A 1 144 ? 133.841 140.018 155.762 1.00 33.03  ? 118 MET A SD  1 
ATOM 725  C CE  . MET A 1 144 ? 134.152 141.677 156.355 1.00 33.03  ? 118 MET A CE  1 
ATOM 726  N N   . GLY A 1 145 ? 130.020 139.780 160.371 1.00 36.60  ? 119 GLY A N   1 
ATOM 727  C CA  . GLY A 1 145 ? 129.230 140.813 161.014 1.00 36.60  ? 119 GLY A CA  1 
ATOM 728  C C   . GLY A 1 145 ? 128.387 141.614 160.041 1.00 36.60  ? 119 GLY A C   1 
ATOM 729  O O   . GLY A 1 145 ? 128.329 141.350 158.838 1.00 36.60  ? 119 GLY A O   1 
ATOM 730  N N   . TYR A 1 146 ? 127.713 142.623 160.591 1.00 41.24  ? 120 TYR A N   1 
ATOM 731  C CA  . TYR A 1 146 ? 126.803 143.450 159.809 1.00 41.24  ? 120 TYR A CA  1 
ATOM 732  C C   . TYR A 1 146 ? 127.560 144.362 158.854 1.00 41.24  ? 120 TYR A C   1 
ATOM 733  O O   . TYR A 1 146 ? 128.667 144.823 159.141 1.00 41.24  ? 120 TYR A O   1 
ATOM 734  C CB  . TYR A 1 146 ? 125.925 144.308 160.719 1.00 41.24  ? 120 TYR A CB  1 
ATOM 735  C CG  . TYR A 1 146 ? 124.964 143.538 161.589 1.00 41.24  ? 120 TYR A CG  1 
ATOM 736  C CD1 . TYR A 1 146 ? 123.964 142.761 161.029 1.00 41.24  ? 120 TYR A CD1 1 
ATOM 737  C CD2 . TYR A 1 146 ? 125.051 143.601 162.974 1.00 41.24  ? 120 TYR A CD2 1 
ATOM 738  C CE1 . TYR A 1 146 ? 123.083 142.057 161.820 1.00 41.24  ? 120 TYR A CE1 1 
ATOM 739  C CE2 . TYR A 1 146 ? 124.175 142.902 163.775 1.00 41.24  ? 120 TYR A CE2 1 
ATOM 740  C CZ  . TYR A 1 146 ? 123.192 142.131 163.193 1.00 41.24  ? 120 TYR A CZ  1 
ATOM 741  O OH  . TYR A 1 146 ? 122.314 141.430 163.987 1.00 41.24  ? 120 TYR A OH  1 
ATOM 742  N N   . TYR A 1 147 ? 126.939 144.628 157.711 1.00 41.43  ? 121 TYR A N   1 
ATOM 743  C CA  . TYR A 1 147 ? 127.497 145.512 156.700 1.00 41.43  ? 121 TYR A CA  1 
ATOM 744  C C   . TYR A 1 147 ? 127.074 146.945 156.981 1.00 41.43  ? 121 TYR A C   1 
ATOM 745  O O   . TYR A 1 147 ? 125.895 147.211 157.229 1.00 41.43  ? 121 TYR A O   1 
ATOM 746  C CB  . TYR A 1 147 ? 127.032 145.082 155.310 1.00 41.43  ? 121 TYR A CB  1 
ATOM 747  C CG  . TYR A 1 147 ? 127.208 146.122 154.229 1.00 41.43  ? 121 TYR A CG  1 
ATOM 748  C CD1 . TYR A 1 147 ? 128.469 146.564 153.860 1.00 41.43  ? 121 TYR A CD1 1 
ATOM 749  C CD2 . TYR A 1 147 ? 126.110 146.647 153.567 1.00 41.43  ? 121 TYR A CD2 1 
ATOM 750  C CE1 . TYR A 1 147 ? 128.629 147.505 152.869 1.00 41.43  ? 121 TYR A CE1 1 
ATOM 751  C CE2 . TYR A 1 147 ? 126.261 147.589 152.578 1.00 41.43  ? 121 TYR A CE2 1 
ATOM 752  C CZ  . TYR A 1 147 ? 127.522 148.014 152.234 1.00 41.43  ? 121 TYR A CZ  1 
ATOM 753  O OH  . TYR A 1 147 ? 127.679 148.954 151.246 1.00 41.43  ? 121 TYR A OH  1 
ATOM 754  N N   . ARG A 1 148 ? 128.033 147.862 156.935 1.00 41.88  ? 122 ARG A N   1 
ATOM 755  C CA  . ARG A 1 148 ? 127.794 149.273 157.201 1.00 41.88  ? 122 ARG A CA  1 
ATOM 756  C C   . ARG A 1 148 ? 128.206 150.087 155.984 1.00 41.88  ? 122 ARG A C   1 
ATOM 757  O O   . ARG A 1 148 ? 129.238 149.809 155.365 1.00 41.88  ? 122 ARG A O   1 
ATOM 758  C CB  . ARG A 1 148 ? 128.557 149.721 158.448 1.00 41.88  ? 122 ARG A CB  1 
ATOM 759  C CG  . ARG A 1 148 ? 129.987 149.235 158.485 1.00 41.88  ? 122 ARG A CG  1 
ATOM 760  C CD  . ARG A 1 148 ? 130.611 149.388 159.851 1.00 41.88  ? 122 ARG A CD  1 
ATOM 761  N NE  . ARG A 1 148 ? 131.821 148.584 159.966 1.00 41.88  ? 122 ARG A NE  1 
ATOM 762  C CZ  . ARG A 1 148 ? 131.844 147.280 160.206 1.00 41.88  ? 122 ARG A CZ  1 
ATOM 763  N NH1 . ARG A 1 148 ? 130.732 146.590 160.398 1.00 41.88  ? 122 ARG A NH1 1 
ATOM 764  N NH2 . ARG A 1 148 ? 133.016 146.653 160.265 1.00 41.88  ? 122 ARG A NH2 1 
ATOM 765  N N   . TYR A 1 149 ? 127.391 151.080 155.630 1.00 47.45  ? 123 TYR A N   1 
ATOM 766  C CA  . TYR A 1 149 ? 127.613 151.866 154.424 1.00 47.45  ? 123 TYR A CA  1 
ATOM 767  C C   . TYR A 1 149 ? 127.869 153.342 154.686 1.00 47.45  ? 123 TYR A C   1 
ATOM 768  O O   . TYR A 1 149 ? 128.557 153.984 153.891 1.00 47.45  ? 123 TYR A O   1 
ATOM 769  C CB  . TYR A 1 149 ? 126.419 151.730 153.468 1.00 47.45  ? 123 TYR A CB  1 
ATOM 770  C CG  . TYR A 1 149 ? 125.070 151.691 154.148 1.00 47.45  ? 123 TYR A CG  1 
ATOM 771  C CD1 . TYR A 1 149 ? 124.429 152.863 154.524 1.00 47.45  ? 123 TYR A CD1 1 
ATOM 772  C CD2 . TYR A 1 149 ? 124.434 150.482 154.407 1.00 47.45  ? 123 TYR A CD2 1 
ATOM 773  C CE1 . TYR A 1 149 ? 123.196 152.835 155.145 1.00 47.45  ? 123 TYR A CE1 1 
ATOM 774  C CE2 . TYR A 1 149 ? 123.201 150.443 155.030 1.00 47.45  ? 123 TYR A CE2 1 
ATOM 775  C CZ  . TYR A 1 149 ? 122.587 151.624 155.396 1.00 47.45  ? 123 TYR A CZ  1 
ATOM 776  O OH  . TYR A 1 149 ? 121.359 151.593 156.015 1.00 47.45  ? 123 TYR A OH  1 
ATOM 777  N N   . SER A 1 150 ? 127.340 153.892 155.773 1.00 50.97  ? 124 SER A N   1 
ATOM 778  C CA  . SER A 1 150 ? 127.569 155.293 156.101 1.00 50.97  ? 124 SER A CA  1 
ATOM 779  C C   . SER A 1 150 ? 127.822 155.462 157.595 1.00 50.97  ? 124 SER A C   1 
ATOM 780  O O   . SER A 1 150 ? 128.080 154.489 158.305 1.00 50.97  ? 124 SER A O   1 
ATOM 781  C CB  . SER A 1 150 ? 126.380 156.151 155.664 1.00 50.97  ? 124 SER A CB  1 
ATOM 782  O OG  . SER A 1 150 ? 125.158 155.604 156.124 1.00 50.97  ? 124 SER A OG  1 
ATOM 783  N N   . THR A 1 164 ? 126.004 168.574 139.964 1.00 101.32 ? 138 THR A N   1 
ATOM 784  C CA  . THR A 1 164 ? 126.717 169.438 139.031 1.00 101.32 ? 138 THR A CA  1 
ATOM 785  C C   . THR A 1 164 ? 125.855 169.762 137.816 1.00 101.32 ? 138 THR A C   1 
ATOM 786  O O   . THR A 1 164 ? 125.695 168.933 136.920 1.00 101.32 ? 138 THR A O   1 
ATOM 787  C CB  . THR A 1 164 ? 128.034 168.794 138.558 1.00 101.32 ? 138 THR A CB  1 
ATOM 788  N N   . LEU A 1 165 ? 125.294 170.974 137.801 1.00 102.17 ? 139 LEU A N   1 
ATOM 789  C CA  . LEU A 1 165 ? 124.482 171.400 136.665 1.00 102.17 ? 139 LEU A CA  1 
ATOM 790  C C   . LEU A 1 165 ? 125.344 171.654 135.436 1.00 102.17 ? 139 LEU A C   1 
ATOM 791  O O   . LEU A 1 165 ? 124.911 171.393 134.305 1.00 102.17 ? 139 LEU A O   1 
ATOM 792  C CB  . LEU A 1 165 ? 123.684 172.651 137.030 1.00 102.17 ? 139 LEU A CB  1 
ATOM 793  N N   . SER A 1 166 ? 126.565 172.163 135.649 1.00 103.94 ? 140 SER A N   1 
ATOM 794  C CA  . SER A 1 166 ? 127.566 172.448 134.613 1.00 103.94 ? 140 SER A CA  1 
ATOM 795  C C   . SER A 1 166 ? 127.026 173.418 133.558 1.00 103.94 ? 140 SER A C   1 
ATOM 796  O O   . SER A 1 166 ? 126.904 173.095 132.376 1.00 103.94 ? 140 SER A O   1 
ATOM 797  C CB  . SER A 1 166 ? 128.089 171.157 133.970 1.00 103.94 ? 140 SER A CB  1 
ATOM 798  N N   . THR A 1 167 ? 126.693 174.618 134.016 1.00 106.11 ? 141 THR A N   1 
ATOM 799  C CA  . THR A 1 167 ? 126.201 175.678 133.150 1.00 106.11 ? 141 THR A CA  1 
ATOM 800  C C   . THR A 1 167 ? 127.318 176.669 132.845 1.00 106.11 ? 141 THR A C   1 
ATOM 801  O O   . THR A 1 167 ? 128.304 176.777 133.577 1.00 106.11 ? 141 THR A O   1 
ATOM 802  C CB  . THR A 1 167 ? 125.018 176.404 133.795 1.00 106.11 ? 141 THR A CB  1 
ATOM 803  N N   . CYS A 1 168 ? 127.149 177.396 131.743 1.00 108.91 ? 142 CYS A N   1 
ATOM 804  C CA  . CYS A 1 168 ? 128.147 178.371 131.324 1.00 108.91 ? 142 CYS A CA  1 
ATOM 805  C C   . CYS A 1 168 ? 128.113 179.588 132.238 1.00 108.91 ? 142 CYS A C   1 
ATOM 806  O O   . CYS A 1 168 ? 127.099 180.288 132.320 1.00 108.91 ? 142 CYS A O   1 
ATOM 807  C CB  . CYS A 1 168 ? 127.902 178.785 129.874 1.00 108.91 ? 142 CYS A CB  1 
ATOM 808  S SG  . CYS A 1 168 ? 129.153 179.894 129.190 1.00 108.91 ? 142 CYS A SG  1 
ATOM 809  N N   . LEU A 1 169 ? 129.225 179.837 132.926 1.00 109.38 ? 143 LEU A N   1 
ATOM 810  C CA  . LEU A 1 169 ? 129.319 180.932 133.882 1.00 109.38 ? 143 LEU A CA  1 
ATOM 811  C C   . LEU A 1 169 ? 129.968 182.143 133.225 1.00 109.38 ? 143 LEU A C   1 
ATOM 812  O O   . LEU A 1 169 ? 130.973 182.012 132.519 1.00 109.38 ? 143 LEU A O   1 
ATOM 813  C CB  . LEU A 1 169 ? 130.120 180.504 135.113 1.00 109.38 ? 143 LEU A CB  1 
ATOM 814  N N   . ILE A 1 170 ? 129.390 183.316 133.458 1.00 108.36 ? 144 ILE A N   1 
ATOM 815  C CA  . ILE A 1 170 ? 129.918 184.553 132.903 1.00 108.36 ? 144 ILE A CA  1 
ATOM 816  C C   . ILE A 1 170 ? 130.223 185.539 134.023 1.00 108.36 ? 144 ILE A C   1 
ATOM 817  O O   . ILE A 1 170 ? 130.073 185.219 135.201 1.00 108.36 ? 144 ILE A O   1 
ATOM 818  C CB  . ILE A 1 170 ? 128.943 185.166 131.884 1.00 108.36 ? 144 ILE A CB  1 
ATOM 819  N N   . SER A 1 194 ? 139.454 143.197 155.517 1.00 41.35  ? 168 SER A N   1 
ATOM 820  C CA  . SER A 1 194 ? 140.416 143.613 154.507 1.00 41.35  ? 168 SER A CA  1 
ATOM 821  C C   . SER A 1 194 ? 141.268 142.432 154.080 1.00 41.35  ? 168 SER A C   1 
ATOM 822  O O   . SER A 1 194 ? 142.096 142.554 153.182 1.00 41.35  ? 168 SER A O   1 
ATOM 823  C CB  . SER A 1 194 ? 141.302 144.745 155.030 1.00 41.35  ? 168 SER A CB  1 
ATOM 824  O OG  . SER A 1 194 ? 142.204 145.196 154.036 1.00 41.35  ? 168 SER A OG  1 
ATOM 825  N N   . TYR A 1 195 ? 141.071 141.288 154.733 1.00 39.53  ? 169 TYR A N   1 
ATOM 826  C CA  . TYR A 1 195 ? 141.760 140.058 154.362 1.00 39.53  ? 169 TYR A CA  1 
ATOM 827  C C   . TYR A 1 195 ? 140.806 138.897 154.136 1.00 39.53  ? 169 TYR A C   1 
ATOM 828  O O   . TYR A 1 195 ? 141.264 137.769 153.931 1.00 39.53  ? 169 TYR A O   1 
ATOM 829  C CB  . TYR A 1 195 ? 142.793 139.668 155.423 1.00 39.53  ? 169 TYR A CB  1 
ATOM 830  C CG  . TYR A 1 195 ? 144.167 140.239 155.174 1.00 39.53  ? 169 TYR A CG  1 
ATOM 831  C CD1 . TYR A 1 195 ? 144.397 141.607 155.252 1.00 39.53  ? 169 TYR A CD1 1 
ATOM 832  C CD2 . TYR A 1 195 ? 145.229 139.413 154.833 1.00 39.53  ? 169 TYR A CD2 1 
ATOM 833  C CE1 . TYR A 1 195 ? 145.649 142.135 155.015 1.00 39.53  ? 169 TYR A CE1 1 
ATOM 834  C CE2 . TYR A 1 195 ? 146.486 139.931 154.593 1.00 39.53  ? 169 TYR A CE2 1 
ATOM 835  C CZ  . TYR A 1 195 ? 146.690 141.293 154.686 1.00 39.53  ? 169 TYR A CZ  1 
ATOM 836  O OH  . TYR A 1 195 ? 147.941 141.817 154.449 1.00 39.53  ? 169 TYR A OH  1 
ATOM 837  N N   . MET A 1 196 ? 139.496 139.138 154.165 1.00 36.97  ? 170 MET A N   1 
ATOM 838  C CA  . MET A 1 196 ? 138.530 138.054 154.053 1.00 36.97  ? 170 MET A CA  1 
ATOM 839  C C   . MET A 1 196 ? 138.349 137.561 152.626 1.00 36.97  ? 170 MET A C   1 
ATOM 840  O O   . MET A 1 196 ? 137.864 136.438 152.432 1.00 36.97  ? 170 MET A O   1 
ATOM 841  C CB  . MET A 1 196 ? 137.186 138.491 154.626 1.00 36.97  ? 170 MET A CB  1 
ATOM 842  C CG  . MET A 1 196 ? 137.054 138.216 156.104 1.00 36.97  ? 170 MET A CG  1 
ATOM 843  S SD  . MET A 1 196 ? 137.370 136.488 156.473 1.00 36.97  ? 170 MET A SD  1 
ATOM 844  C CE  . MET A 1 196 ? 136.381 136.296 157.945 1.00 36.97  ? 170 MET A CE  1 
ATOM 845  N N   . TRP A 1 197 ? 138.781 138.348 151.635 1.00 37.63  ? 171 TRP A N   1 
ATOM 846  C CA  . TRP A 1 197 ? 138.659 137.974 150.229 1.00 37.63  ? 171 TRP A CA  1 
ATOM 847  C C   . TRP A 1 197 ? 139.462 136.727 149.877 1.00 37.63  ? 171 TRP A C   1 
ATOM 848  O O   . TRP A 1 197 ? 139.184 136.105 148.846 1.00 37.63  ? 171 TRP A O   1 
ATOM 849  C CB  . TRP A 1 197 ? 139.104 139.139 149.348 1.00 37.63  ? 171 TRP A CB  1 
ATOM 850  C CG  . TRP A 1 197 ? 140.404 139.739 149.774 1.00 37.63  ? 171 TRP A CG  1 
ATOM 851  C CD1 . TRP A 1 197 ? 140.578 140.809 150.594 1.00 37.63  ? 171 TRP A CD1 1 
ATOM 852  C CD2 . TRP A 1 197 ? 141.716 139.295 149.411 1.00 37.63  ? 171 TRP A CD2 1 
ATOM 853  N NE1 . TRP A 1 197 ? 141.914 141.063 150.763 1.00 37.63  ? 171 TRP A NE1 1 
ATOM 854  C CE2 . TRP A 1 197 ? 142.634 140.144 150.049 1.00 37.63  ? 171 TRP A CE2 1 
ATOM 855  C CE3 . TRP A 1 197 ? 142.203 138.262 148.606 1.00 37.63  ? 171 TRP A CE3 1 
ATOM 856  C CZ2 . TRP A 1 197 ? 144.008 139.995 149.907 1.00 37.63  ? 171 TRP A CZ2 1 
ATOM 857  C CZ3 . TRP A 1 197 ? 143.565 138.113 148.470 1.00 37.63  ? 171 TRP A CZ3 1 
ATOM 858  C CH2 . TRP A 1 197 ? 144.453 138.974 149.116 1.00 37.63  ? 171 TRP A CH2 1 
ATOM 859  N N   . ILE A 1 198 ? 140.446 136.362 150.708 1.00 34.65  ? 172 ILE A N   1 
ATOM 860  C CA  . ILE A 1 198 ? 141.189 135.116 150.544 1.00 34.65  ? 172 ILE A CA  1 
ATOM 861  C C   . ILE A 1 198 ? 140.246 133.922 150.592 1.00 34.65  ? 172 ILE A C   1 
ATOM 862  O O   . ILE A 1 198 ? 140.389 132.974 149.808 1.00 34.65  ? 172 ILE A O   1 
ATOM 863  C CB  . ILE A 1 198 ? 142.290 135.012 151.617 1.00 34.65  ? 172 ILE A CB  1 
ATOM 864  C CG1 . ILE A 1 198 ? 143.155 136.272 151.613 1.00 34.65  ? 172 ILE A CG1 1 
ATOM 865  C CG2 . ILE A 1 198 ? 143.147 133.770 151.409 1.00 34.65  ? 172 ILE A CG2 1 
ATOM 866  C CD1 . ILE A 1 198 ? 144.154 136.326 152.741 1.00 34.65  ? 172 ILE A CD1 1 
ATOM 867  N N   . TYR A 1 199 ? 139.238 133.973 151.476 1.00 34.25  ? 173 TYR A N   1 
ATOM 868  C CA  . TYR A 1 199 ? 138.229 132.917 151.502 1.00 34.25  ? 173 TYR A CA  1 
ATOM 869  C C   . TYR A 1 199 ? 137.421 132.882 150.212 1.00 34.25  ? 173 TYR A C   1 
ATOM 870  O O   . TYR A 1 199 ? 136.970 131.813 149.788 1.00 34.25  ? 173 TYR A O   1 
ATOM 871  C CB  . TYR A 1 199 ? 137.297 133.076 152.704 1.00 34.25  ? 173 TYR A CB  1 
ATOM 872  C CG  . TYR A 1 199 ? 137.849 132.621 154.034 1.00 34.25  ? 173 TYR A CG  1 
ATOM 873  C CD1 . TYR A 1 199 ? 139.093 132.010 154.122 1.00 34.25  ? 173 TYR A CD1 1 
ATOM 874  C CD2 . TYR A 1 199 ? 137.094 132.744 155.194 1.00 34.25  ? 173 TYR A CD2 1 
ATOM 875  C CE1 . TYR A 1 199 ? 139.591 131.572 155.335 1.00 34.25  ? 173 TYR A CE1 1 
ATOM 876  C CE2 . TYR A 1 199 ? 137.578 132.306 156.412 1.00 34.25  ? 173 TYR A CE2 1 
ATOM 877  C CZ  . TYR A 1 199 ? 138.829 131.721 156.475 1.00 34.25  ? 173 TYR A CZ  1 
ATOM 878  O OH  . TYR A 1 199 ? 139.332 131.280 157.677 1.00 34.25  ? 173 TYR A OH  1 
ATOM 879  N N   . VAL A 1 200 ? 137.226 134.035 149.573 1.00 34.56  ? 174 VAL A N   1 
ATOM 880  C CA  . VAL A 1 200 ? 136.696 134.026 148.216 1.00 34.56  ? 174 VAL A CA  1 
ATOM 881  C C   . VAL A 1 200 ? 137.727 133.439 147.263 1.00 34.56  ? 174 VAL A C   1 
ATOM 882  O O   . VAL A 1 200 ? 137.430 132.494 146.519 1.00 34.56  ? 174 VAL A O   1 
ATOM 883  C CB  . VAL A 1 200 ? 136.276 135.443 147.788 1.00 34.56  ? 174 VAL A CB  1 
ATOM 884  C CG1 . VAL A 1 200 ? 135.570 135.395 146.452 1.00 34.56  ? 174 VAL A CG1 1 
ATOM 885  C CG2 . VAL A 1 200 ? 135.382 136.074 148.837 1.00 34.56  ? 174 VAL A CG2 1 
ATOM 886  N N   . PHE A 1 201 ? 138.974 133.928 147.364 1.00 34.17  ? 175 PHE A N   1 
ATOM 887  C CA  . PHE A 1 201 ? 140.034 133.676 146.386 1.00 34.17  ? 175 PHE A CA  1 
ATOM 888  C C   . PHE A 1 201 ? 140.322 132.188 146.252 1.00 34.17  ? 175 PHE A C   1 
ATOM 889  O O   . PHE A 1 201 ? 140.093 131.594 145.189 1.00 34.17  ? 175 PHE A O   1 
ATOM 890  C CB  . PHE A 1 201 ? 141.292 134.445 146.812 1.00 34.17  ? 175 PHE A CB  1 
ATOM 891  C CG  . PHE A 1 201 ? 142.575 133.920 146.224 1.00 34.17  ? 175 PHE A CG  1 
ATOM 892  C CD1 . PHE A 1 201 ? 142.877 134.117 144.895 1.00 34.17  ? 175 PHE A CD1 1 
ATOM 893  C CD2 . PHE A 1 201 ? 143.487 133.237 147.014 1.00 34.17  ? 175 PHE A CD2 1 
ATOM 894  C CE1 . PHE A 1 201 ? 144.055 133.632 144.355 1.00 34.17  ? 175 PHE A CE1 1 
ATOM 895  C CE2 . PHE A 1 201 ? 144.662 132.747 146.480 1.00 34.17  ? 175 PHE A CE2 1 
ATOM 896  C CZ  . PHE A 1 201 ? 144.943 132.948 145.147 1.00 34.17  ? 175 PHE A CZ  1 
ATOM 897  N N   . MET A 1 202 ? 140.722 131.563 147.365 1.00 37.10  ? 176 MET A N   1 
ATOM 898  C CA  . MET A 1 202 ? 140.972 130.128 147.404 1.00 37.10  ? 176 MET A CA  1 
ATOM 899  C C   . MET A 1 202 ? 139.724 129.341 147.049 1.00 37.10  ? 176 MET A C   1 
ATOM 900  O O   . MET A 1 202 ? 139.810 128.330 146.339 1.00 37.10  ? 176 MET A O   1 
ATOM 901  C CB  . MET A 1 202 ? 141.473 129.726 148.789 1.00 37.10  ? 176 MET A CB  1 
ATOM 902  C CG  . MET A 1 202 ? 142.736 130.430 149.217 1.00 37.10  ? 176 MET A CG  1 
ATOM 903  S SD  . MET A 1 202 ? 144.198 129.741 148.432 1.00 37.10  ? 176 MET A SD  1 
ATOM 904  C CE  . MET A 1 202 ? 143.892 127.988 148.629 1.00 37.10  ? 176 MET A CE  1 
ATOM 905  N N   . GLY A 1 203 ? 138.554 129.834 147.477 1.00 33.68  ? 177 GLY A N   1 
ATOM 906  C CA  . GLY A 1 203 ? 137.311 129.162 147.143 1.00 33.68  ? 177 GLY A CA  1 
ATOM 907  C C   . GLY A 1 203 ? 137.071 129.148 145.651 1.00 33.68  ? 177 GLY A C   1 
ATOM 908  O O   . GLY A 1 203 ? 136.757 128.104 145.072 1.00 33.68  ? 177 GLY A O   1 
ATOM 909  N N   . ASN A 1 204 ? 137.350 130.281 144.996 1.00 34.75  ? 178 ASN A N   1 
ATOM 910  C CA  . ASN A 1 204 ? 137.229 130.346 143.547 1.00 34.75  ? 178 ASN A CA  1 
ATOM 911  C C   . ASN A 1 204 ? 138.299 129.460 142.924 1.00 34.75  ? 178 ASN A C   1 
ATOM 912  O O   . ASN A 1 204 ? 138.029 128.730 141.962 1.00 34.75  ? 178 ASN A O   1 
ATOM 913  C CB  . ASN A 1 204 ? 137.359 131.807 143.101 1.00 34.75  ? 178 ASN A CB  1 
ATOM 914  C CG  . ASN A 1 204 ? 137.170 132.020 141.602 1.00 34.75  ? 178 ASN A CG  1 
ATOM 915  O OD1 . ASN A 1 204 ? 136.936 131.096 140.833 1.00 34.75  ? 178 ASN A OD1 1 
ATOM 916  N ND2 . ASN A 1 204 ? 137.288 133.272 141.184 1.00 34.75  ? 178 ASN A ND2 1 
ATOM 917  N N   . MET A 1 205 ? 139.490 129.439 143.541 1.00 35.89  ? 179 MET A N   1 
ATOM 918  C CA  . MET A 1 205 ? 140.563 128.560 143.094 1.00 35.89  ? 179 MET A CA  1 
ATOM 919  C C   . MET A 1 205 ? 140.166 127.104 143.249 1.00 35.89  ? 179 MET A C   1 
ATOM 920  O O   . MET A 1 205 ? 140.494 126.270 142.396 1.00 35.89  ? 179 MET A O   1 
ATOM 921  C CB  . MET A 1 205 ? 141.841 128.854 143.879 1.00 35.89  ? 179 MET A CB  1 
ATOM 922  C CG  . MET A 1 205 ? 143.046 128.048 143.439 1.00 35.89  ? 179 MET A CG  1 
ATOM 923  S SD  . MET A 1 205 ? 144.541 128.494 144.327 1.00 35.89  ? 179 MET A SD  1 
ATOM 924  C CE  . MET A 1 205 ? 145.694 127.306 143.648 1.00 35.89  ? 179 MET A CE  1 
ATOM 925  N N   . LEU A 1 206 ? 139.403 126.796 144.303 1.00 33.74  ? 180 LEU A N   1 
ATOM 926  C CA  . LEU A 1 206 ? 138.936 125.431 144.492 1.00 33.74  ? 180 LEU A CA  1 
ATOM 927  C C   . LEU A 1 206 ? 137.927 125.074 143.410 1.00 33.74  ? 180 LEU A C   1 
ATOM 928  O O   . LEU A 1 206 ? 137.935 123.952 142.888 1.00 33.74  ? 180 LEU A O   1 
ATOM 929  C CB  . LEU A 1 206 ? 138.352 125.282 145.895 1.00 33.74  ? 180 LEU A CB  1 
ATOM 930  C CG  . LEU A 1 206 ? 138.186 123.879 146.472 1.00 33.74  ? 180 LEU A CG  1 
ATOM 931  C CD1 . LEU A 1 206 ? 139.534 123.195 146.563 1.00 33.74  ? 180 LEU A CD1 1 
ATOM 932  C CD2 . LEU A 1 206 ? 137.541 123.942 147.842 1.00 33.74  ? 180 LEU A CD2 1 
ATOM 933  N N   . ARG A 1 207 ? 137.127 126.063 142.989 1.00 35.24  ? 181 ARG A N   1 
ATOM 934  C CA  . ARG A 1 207 ? 136.242 125.890 141.844 1.00 35.24  ? 181 ARG A CA  1 
ATOM 935  C C   . ARG A 1 207 ? 137.033 125.669 140.563 1.00 35.24  ? 181 ARG A C   1 
ATOM 936  O O   . ARG A 1 207 ? 136.579 124.939 139.674 1.00 35.24  ? 181 ARG A O   1 
ATOM 937  C CB  . ARG A 1 207 ? 135.327 127.108 141.713 1.00 35.24  ? 181 ARG A CB  1 
ATOM 938  C CG  . ARG A 1 207 ? 134.213 126.959 140.707 1.00 35.24  ? 181 ARG A CG  1 
ATOM 939  C CD  . ARG A 1 207 ? 133.272 128.144 140.754 1.00 35.24  ? 181 ARG A CD  1 
ATOM 940  N NE  . ARG A 1 207 ? 133.858 129.332 140.150 1.00 35.24  ? 181 ARG A NE  1 
ATOM 941  C CZ  . ARG A 1 207 ? 133.727 129.663 138.874 1.00 35.24  ? 181 ARG A CZ  1 
ATOM 942  N NH1 . ARG A 1 207 ? 133.061 128.897 138.027 1.00 35.24  ? 181 ARG A NH1 1 
ATOM 943  N NH2 . ARG A 1 207 ? 134.277 130.790 138.436 1.00 35.24  ? 181 ARG A NH2 1 
ATOM 944  N N   . GLY A 1 208 ? 138.233 126.257 140.471 1.00 33.88  ? 182 GLY A N   1 
ATOM 945  C CA  . GLY A 1 208 ? 139.110 125.974 139.349 1.00 33.88  ? 182 GLY A CA  1 
ATOM 946  C C   . GLY A 1 208 ? 139.560 124.531 139.304 1.00 33.88  ? 182 GLY A C   1 
ATOM 947  O O   . GLY A 1 208 ? 139.731 123.963 138.225 1.00 33.88  ? 182 GLY A O   1 
ATOM 948  N N   . ILE A 1 209 ? 139.724 123.907 140.468 1.00 32.77  ? 183 ILE A N   1 
ATOM 949  C CA  . ILE A 1 209 ? 140.066 122.494 140.491 1.00 32.77  ? 183 ILE A CA  1 
ATOM 950  C C   . ILE A 1 209 ? 138.795 121.664 140.331 1.00 32.77  ? 183 ILE A C   1 
ATOM 951  O O   . ILE A 1 209 ? 138.839 120.475 139.997 1.00 32.77  ? 183 ILE A O   1 
ATOM 952  C CB  . ILE A 1 209 ? 140.830 122.200 141.797 1.00 32.77  ? 183 ILE A CB  1 
ATOM 953  C CG1 . ILE A 1 209 ? 142.019 123.145 141.900 1.00 32.77  ? 183 ILE A CG1 1 
ATOM 954  C CG2 . ILE A 1 209 ? 141.436 120.808 141.817 1.00 32.77  ? 183 ILE A CG2 1 
ATOM 955  C CD1 . ILE A 1 209 ? 142.683 123.144 143.248 1.00 32.77  ? 183 ILE A CD1 1 
ATOM 956  N N   . GLY A 1 210 ? 137.636 122.304 140.496 1.00 33.00  ? 184 GLY A N   1 
ATOM 957  C CA  . GLY A 1 210 ? 136.386 121.569 140.473 1.00 33.00  ? 184 GLY A CA  1 
ATOM 958  C C   . GLY A 1 210 ? 135.912 121.215 139.076 1.00 33.00  ? 184 GLY A C   1 
ATOM 959  O O   . GLY A 1 210 ? 135.536 120.071 138.814 1.00 33.00  ? 184 GLY A O   1 
ATOM 960  N N   . GLU A 1 211 ? 135.921 122.185 138.163 1.00 35.83  ? 185 GLU A N   1 
ATOM 961  C CA  . GLU A 1 211 ? 135.445 121.979 136.799 1.00 35.83  ? 185 GLU A CA  1 
ATOM 962  C C   . GLU A 1 211 ? 136.431 121.161 135.964 1.00 35.83  ? 185 GLU A C   1 
ATOM 963  O O   . GLU A 1 211 ? 136.045 120.618 134.920 1.00 35.83  ? 185 GLU A O   1 
ATOM 964  C CB  . GLU A 1 211 ? 135.113 123.369 136.204 1.00 35.83  ? 185 GLU A CB  1 
ATOM 965  C CG  . GLU A 1 211 ? 135.132 123.587 134.686 1.00 35.83  ? 185 GLU A CG  1 
ATOM 966  C CD  . GLU A 1 211 ? 134.536 124.919 134.280 1.00 35.83  ? 185 GLU A CD  1 
ATOM 967  O OE1 . GLU A 1 211 ? 134.466 125.822 135.135 1.00 35.83  ? 185 GLU A OE1 1 
ATOM 968  O OE2 . GLU A 1 211 ? 134.139 125.062 133.104 1.00 35.83  ? 185 GLU A OE2 1 
ATOM 969  N N   . THR A 1 212 ? 137.644 120.963 136.486 1.00 31.38  ? 186 THR A N   1 
ATOM 970  C CA  . THR A 1 212 ? 138.744 120.313 135.772 1.00 31.38  ? 186 THR A CA  1 
ATOM 971  C C   . THR A 1 212 ? 138.467 118.914 135.204 1.00 31.38  ? 186 THR A C   1 
ATOM 972  O O   . THR A 1 212 ? 138.725 118.719 134.003 1.00 31.38  ? 186 THR A O   1 
ATOM 973  C CB  . THR A 1 212 ? 139.968 120.326 136.696 1.00 31.38  ? 186 THR A CB  1 
ATOM 974  O OG1 . THR A 1 212 ? 140.359 121.677 136.967 1.00 31.38  ? 186 THR A OG1 1 
ATOM 975  C CG2 . THR A 1 212 ? 141.086 119.565 136.121 1.00 31.38  ? 186 THR A CG2 1 
ATOM 976  N N   . PRO A 1 213 ? 137.940 117.922 135.933 1.00 32.03  ? 187 PRO A N   1 
ATOM 977  C CA  . PRO A 1 213 ? 137.800 116.598 135.318 1.00 32.03  ? 187 PRO A CA  1 
ATOM 978  C C   . PRO A 1 213 ? 136.531 116.400 134.502 1.00 32.03  ? 187 PRO A C   1 
ATOM 979  O O   . PRO A 1 213 ? 136.208 115.257 134.175 1.00 32.03  ? 187 PRO A O   1 
ATOM 980  C CB  . PRO A 1 213 ? 137.806 115.669 136.537 1.00 32.03  ? 187 PRO A CB  1 
ATOM 981  C CG  . PRO A 1 213 ? 137.078 116.425 137.525 1.00 32.03  ? 187 PRO A CG  1 
ATOM 982  C CD  . PRO A 1 213 ? 137.465 117.858 137.334 1.00 32.03  ? 187 PRO A CD  1 
ATOM 983  N N   . ILE A 1 214 ? 135.809 117.456 134.150 1.00 30.12  ? 188 ILE A N   1 
ATOM 984  C CA  . ILE A 1 214 ? 134.479 117.302 133.570 1.00 30.12  ? 188 ILE A CA  1 
ATOM 985  C C   . ILE A 1 214 ? 134.541 117.119 132.059 1.00 30.12  ? 188 ILE A C   1 
ATOM 986  O O   . ILE A 1 214 ? 133.951 116.180 131.517 1.00 30.12  ? 188 ILE A O   1 
ATOM 987  C CB  . ILE A 1 214 ? 133.592 118.500 133.972 1.00 30.12  ? 188 ILE A CB  1 
ATOM 988  C CG1 . ILE A 1 214 ? 133.310 118.455 135.474 1.00 30.12  ? 188 ILE A CG1 1 
ATOM 989  C CG2 . ILE A 1 214 ? 132.291 118.488 133.206 1.00 30.12  ? 188 ILE A CG2 1 
ATOM 990  C CD1 . ILE A 1 214 ? 132.571 119.652 135.996 1.00 30.12  ? 188 ILE A CD1 1 
ATOM 991  N N   . VAL A 1 215 ? 135.253 117.988 131.347 1.00 30.34  ? 189 VAL A N   1 
ATOM 992  C CA  . VAL A 1 215 ? 135.339 117.866 129.891 1.00 30.34  ? 189 VAL A CA  1 
ATOM 993  C C   . VAL A 1 215 ? 136.227 116.689 129.476 1.00 30.34  ? 189 VAL A C   1 
ATOM 994  O O   . VAL A 1 215 ? 135.708 115.816 128.769 1.00 30.34  ? 189 VAL A O   1 
ATOM 995  C CB  . VAL A 1 215 ? 135.771 119.193 129.234 1.00 30.34  ? 189 VAL A CB  1 
ATOM 996  C CG1 . VAL A 1 215 ? 136.297 118.956 127.826 1.00 30.34  ? 189 VAL A CG1 1 
ATOM 997  C CG2 . VAL A 1 215 ? 134.615 120.148 129.184 1.00 30.34  ? 189 VAL A CG2 1 
ATOM 998  N N   . PRO A 1 216 ? 137.554 116.559 129.876 1.00 24.93  ? 190 PRO A N   1 
ATOM 999  C CA  . PRO A 1 216 ? 138.342 115.451 129.308 1.00 24.93  ? 190 PRO A CA  1 
ATOM 1000 C C   . PRO A 1 216 ? 137.906 114.055 129.742 1.00 24.93  ? 190 PRO A C   1 
ATOM 1001 O O   . PRO A 1 216 ? 137.653 113.207 128.878 1.00 24.93  ? 190 PRO A O   1 
ATOM 1002 C CB  . PRO A 1 216 ? 139.769 115.756 129.777 1.00 24.93  ? 190 PRO A CB  1 
ATOM 1003 C CG  . PRO A 1 216 ? 139.620 116.556 130.968 1.00 24.93  ? 190 PRO A CG  1 
ATOM 1004 C CD  . PRO A 1 216 ? 138.405 117.378 130.771 1.00 24.93  ? 190 PRO A CD  1 
ATOM 1005 N N   . LEU A 1 217 ? 137.775 113.819 131.052 1.00 31.96  ? 191 LEU A N   1 
ATOM 1006 C CA  . LEU A 1 217 ? 137.395 112.498 131.544 1.00 31.96  ? 191 LEU A CA  1 
ATOM 1007 C C   . LEU A 1 217 ? 135.963 112.154 131.162 1.00 31.96  ? 191 LEU A C   1 
ATOM 1008 O O   . LEU A 1 217 ? 135.677 111.013 130.785 1.00 31.96  ? 191 LEU A O   1 
ATOM 1009 C CB  . LEU A 1 217 ? 137.566 112.424 133.059 1.00 31.96  ? 191 LEU A CB  1 
ATOM 1010 C CG  . LEU A 1 217 ? 138.932 112.754 133.649 1.00 31.96  ? 191 LEU A CG  1 
ATOM 1011 C CD1 . LEU A 1 217 ? 138.955 112.378 135.111 1.00 31.96  ? 191 LEU A CD1 1 
ATOM 1012 C CD2 . LEU A 1 217 ? 140.031 112.042 132.900 1.00 31.96  ? 191 LEU A CD2 1 
ATOM 1013 N N   . GLY A 1 218 ? 135.063 113.137 131.226 1.00 30.05  ? 192 GLY A N   1 
ATOM 1014 C CA  . GLY A 1 218 ? 133.677 112.887 130.869 1.00 30.05  ? 192 GLY A CA  1 
ATOM 1015 C C   . GLY A 1 218 ? 133.488 112.572 129.398 1.00 30.05  ? 192 GLY A C   1 
ATOM 1016 O O   . GLY A 1 218 ? 132.785 111.623 129.042 1.00 30.05  ? 192 GLY A O   1 
ATOM 1017 N N   . LEU A 1 219 ? 134.140 113.339 128.521 1.00 29.68  ? 193 LEU A N   1 
ATOM 1018 C CA  . LEU A 1 219 ? 133.942 113.118 127.096 1.00 29.68  ? 193 LEU A CA  1 
ATOM 1019 C C   . LEU A 1 219 ? 134.698 111.886 126.613 1.00 29.68  ? 193 LEU A C   1 
ATOM 1020 O O   . LEU A 1 219 ? 134.228 111.186 125.704 1.00 29.68  ? 193 LEU A O   1 
ATOM 1021 C CB  . LEU A 1 219 ? 134.334 114.368 126.315 1.00 29.68  ? 193 LEU A CB  1 
ATOM 1022 C CG  . LEU A 1 219 ? 133.361 115.531 126.549 1.00 29.68  ? 193 LEU A CG  1 
ATOM 1023 C CD1 . LEU A 1 219 ? 133.729 116.746 125.720 1.00 29.68  ? 193 LEU A CD1 1 
ATOM 1024 C CD2 . LEU A 1 219 ? 131.919 115.116 126.308 1.00 29.68  ? 193 LEU A CD2 1 
ATOM 1025 N N   . SER A 1 220 ? 135.840 111.570 127.237 1.00 32.33  ? 194 SER A N   1 
ATOM 1026 C CA  . SER A 1 220 ? 136.502 110.304 126.944 1.00 32.33  ? 194 SER A CA  1 
ATOM 1027 C C   . SER A 1 220 ? 135.669 109.116 127.408 1.00 32.33  ? 194 SER A C   1 
ATOM 1028 O O   . SER A 1 220 ? 135.585 108.114 126.693 1.00 32.33  ? 194 SER A O   1 
ATOM 1029 C CB  . SER A 1 220 ? 137.884 110.268 127.588 1.00 32.33  ? 194 SER A CB  1 
ATOM 1030 O OG  . SER A 1 220 ? 137.788 110.301 128.998 1.00 32.33  ? 194 SER A OG  1 
ATOM 1031 N N   . TYR A 1 221 ? 135.020 109.222 128.576 1.00 35.84  ? 195 TYR A N   1 
ATOM 1032 C CA  . TYR A 1 221 ? 134.123 108.171 129.048 1.00 35.84  ? 195 TYR A CA  1 
ATOM 1033 C C   . TYR A 1 221 ? 132.917 108.011 128.136 1.00 35.84  ? 195 TYR A C   1 
ATOM 1034 O O   . TYR A 1 221 ? 132.428 106.893 127.942 1.00 35.84  ? 195 TYR A O   1 
ATOM 1035 C CB  . TYR A 1 221 ? 133.663 108.482 130.472 1.00 35.84  ? 195 TYR A CB  1 
ATOM 1036 C CG  . TYR A 1 221 ? 132.977 107.342 131.197 1.00 35.84  ? 195 TYR A CG  1 
ATOM 1037 C CD1 . TYR A 1 221 ? 131.608 107.134 131.077 1.00 35.84  ? 195 TYR A CD1 1 
ATOM 1038 C CD2 . TYR A 1 221 ? 133.694 106.490 132.017 1.00 35.84  ? 195 TYR A CD2 1 
ATOM 1039 C CE1 . TYR A 1 221 ? 130.979 106.113 131.739 1.00 35.84  ? 195 TYR A CE1 1 
ATOM 1040 C CE2 . TYR A 1 221 ? 133.070 105.464 132.685 1.00 35.84  ? 195 TYR A CE2 1 
ATOM 1041 C CZ  . TYR A 1 221 ? 131.713 105.281 132.541 1.00 35.84  ? 195 TYR A CZ  1 
ATOM 1042 O OH  . TYR A 1 221 ? 131.084 104.262 133.207 1.00 35.84  ? 195 TYR A OH  1 
ATOM 1043 N N   . ILE A 1 222 ? 132.397 109.120 127.612 1.00 33.88  ? 196 ILE A N   1 
ATOM 1044 C CA  . ILE A 1 222 ? 131.254 109.046 126.709 1.00 33.88  ? 196 ILE A CA  1 
ATOM 1045 C C   . ILE A 1 222 ? 131.644 108.345 125.418 1.00 33.88  ? 196 ILE A C   1 
ATOM 1046 O O   . ILE A 1 222 ? 130.993 107.383 125.000 1.00 33.88  ? 196 ILE A O   1 
ATOM 1047 C CB  . ILE A 1 222 ? 130.682 110.451 126.441 1.00 33.88  ? 196 ILE A CB  1 
ATOM 1048 C CG1 . ILE A 1 222 ? 129.803 110.898 127.604 1.00 33.88  ? 196 ILE A CG1 1 
ATOM 1049 C CG2 . ILE A 1 222 ? 129.870 110.488 125.157 1.00 33.88  ? 196 ILE A CG2 1 
ATOM 1050 C CD1 . ILE A 1 222 ? 129.331 112.305 127.472 1.00 33.88  ? 196 ILE A CD1 1 
ATOM 1051 N N   . ASP A 1 223 ? 132.749 108.763 124.804 1.00 35.87  ? 197 ASP A N   1 
ATOM 1052 C CA  . ASP A 1 223 ? 132.970 108.352 123.427 1.00 35.87  ? 197 ASP A CA  1 
ATOM 1053 C C   . ASP A 1 223 ? 133.783 107.047 123.411 1.00 35.87  ? 197 ASP A C   1 
ATOM 1054 O O   . ASP A 1 223 ? 133.811 106.336 122.403 1.00 35.87  ? 197 ASP A O   1 
ATOM 1055 C CB  . ASP A 1 223 ? 133.556 109.591 122.714 1.00 35.87  ? 197 ASP A CB  1 
ATOM 1056 C CG  . ASP A 1 223 ? 134.144 109.362 121.318 1.00 35.87  ? 197 ASP A CG  1 
ATOM 1057 O OD1 . ASP A 1 223 ? 133.993 108.343 120.630 1.00 35.87  ? 197 ASP A OD1 1 
ATOM 1058 O OD2 . ASP A 1 223 ? 134.700 110.357 120.830 1.00 35.87  ? 197 ASP A OD2 1 
ATOM 1059 N N   . ASP A 1 224 ? 134.309 106.623 124.565 1.00 36.02  ? 198 ASP A N   1 
ATOM 1060 C CA  . ASP A 1 224 ? 134.899 105.290 124.654 1.00 36.02  ? 198 ASP A CA  1 
ATOM 1061 C C   . ASP A 1 224 ? 133.833 104.202 124.636 1.00 36.02  ? 198 ASP A C   1 
ATOM 1062 O O   . ASP A 1 224 ? 134.025 103.150 124.016 1.00 36.02  ? 198 ASP A O   1 
ATOM 1063 C CB  . ASP A 1 224 ? 135.742 105.168 125.923 1.00 36.02  ? 198 ASP A CB  1 
ATOM 1064 C CG  . ASP A 1 224 ? 137.178 105.589 125.714 1.00 36.02  ? 198 ASP A CG  1 
ATOM 1065 O OD1 . ASP A 1 224 ? 137.532 105.947 124.577 1.00 36.02  ? 198 ASP A OD1 1 
ATOM 1066 O OD2 . ASP A 1 224 ? 137.953 105.563 126.692 1.00 36.02  ? 198 ASP A OD2 1 
ATOM 1067 N N   . PHE A 1 225 ? 132.704 104.432 125.309 1.00 38.30  ? 199 PHE A N   1 
ATOM 1068 C CA  . PHE A 1 225 ? 131.726 103.379 125.543 1.00 38.30  ? 199 PHE A CA  1 
ATOM 1069 C C   . PHE A 1 225 ? 130.436 103.521 124.750 1.00 38.30  ? 199 PHE A C   1 
ATOM 1070 O O   . PHE A 1 225 ? 129.599 102.616 124.812 1.00 38.30  ? 199 PHE A O   1 
ATOM 1071 C CB  . PHE A 1 225 ? 131.372 103.301 127.036 1.00 38.30  ? 199 PHE A CB  1 
ATOM 1072 C CG  . PHE A 1 225 ? 132.524 102.914 127.910 1.00 38.30  ? 199 PHE A CG  1 
ATOM 1073 C CD1 . PHE A 1 225 ? 133.048 101.633 127.858 1.00 38.30  ? 199 PHE A CD1 1 
ATOM 1074 C CD2 . PHE A 1 225 ? 133.078 103.827 128.785 1.00 38.30  ? 199 PHE A CD2 1 
ATOM 1075 C CE1 . PHE A 1 225 ? 134.113 101.274 128.660 1.00 38.30  ? 199 PHE A CE1 1 
ATOM 1076 C CE2 . PHE A 1 225 ? 134.138 103.476 129.590 1.00 38.30  ? 199 PHE A CE2 1 
ATOM 1077 C CZ  . PHE A 1 225 ? 134.657 102.198 129.529 1.00 38.30  ? 199 PHE A CZ  1 
ATOM 1078 N N   . ALA A 1 226 ? 130.242 104.615 124.018 1.00 39.93  ? 200 ALA A N   1 
ATOM 1079 C CA  . ALA A 1 226 ? 128.998 104.790 123.284 1.00 39.93  ? 200 ALA A CA  1 
ATOM 1080 C C   . ALA A 1 226 ? 128.985 103.928 122.024 1.00 39.93  ? 200 ALA A C   1 
ATOM 1081 O O   . ALA A 1 226 ? 129.974 103.287 121.657 1.00 39.93  ? 200 ALA A O   1 
ATOM 1082 C CB  . ALA A 1 226 ? 128.787 106.254 122.906 1.00 39.93  ? 200 ALA A CB  1 
ATOM 1083 N N   . LYS A 1 227 ? 127.832 103.919 121.361 1.00 45.29  ? 201 LYS A N   1 
ATOM 1084 C CA  . LYS A 1 227 ? 127.712 103.273 120.066 1.00 45.29  ? 201 LYS A CA  1 
ATOM 1085 C C   . LYS A 1 227 ? 128.477 104.067 119.012 1.00 45.29  ? 201 LYS A C   1 
ATOM 1086 O O   . LYS A 1 227 ? 128.828 105.233 119.208 1.00 45.29  ? 201 LYS A O   1 
ATOM 1087 C CB  . LYS A 1 227 ? 126.245 103.140 119.667 1.00 45.29  ? 201 LYS A CB  1 
ATOM 1088 C CG  . LYS A 1 227 ? 125.412 102.317 120.634 1.00 45.29  ? 201 LYS A CG  1 
ATOM 1089 C CD  . LYS A 1 227 ? 125.861 100.866 120.649 1.00 45.29  ? 201 LYS A CD  1 
ATOM 1090 C CE  . LYS A 1 227 ? 124.926 100.003 121.485 1.00 45.29  ? 201 LYS A CE  1 
ATOM 1091 N NZ  . LYS A 1 227 ? 125.015 100.310 122.940 1.00 45.29  ? 201 LYS A NZ  1 
ATOM 1092 N N   . GLU A 1 228 ? 128.742 103.413 117.883 1.00 49.52  ? 202 GLU A N   1 
ATOM 1093 C CA  . GLU A 1 228 ? 129.546 104.011 116.821 1.00 49.52  ? 202 GLU A CA  1 
ATOM 1094 C C   . GLU A 1 228 ? 128.760 105.131 116.150 1.00 49.52  ? 202 GLU A C   1 
ATOM 1095 O O   . GLU A 1 228 ? 127.848 104.875 115.358 1.00 49.52  ? 202 GLU A O   1 
ATOM 1096 C CB  . GLU A 1 228 ? 129.956 102.947 115.810 1.00 49.52  ? 202 GLU A CB  1 
ATOM 1097 C CG  . GLU A 1 228 ? 130.870 101.875 116.380 1.00 49.52  ? 202 GLU A CG  1 
ATOM 1098 C CD  . GLU A 1 228 ? 131.314 100.870 115.334 1.00 49.52  ? 202 GLU A CD  1 
ATOM 1099 O OE1 . GLU A 1 228 ? 130.833 100.952 114.185 1.00 49.52  ? 202 GLU A OE1 1 
ATOM 1100 O OE2 . GLU A 1 228 ? 132.145 99.997  115.663 1.00 49.52  ? 202 GLU A OE2 1 
ATOM 1101 N N   . GLY A 1 229 ? 129.112 106.375 116.471 1.00 43.55  ? 203 GLY A N   1 
ATOM 1102 C CA  . GLY A 1 229 ? 128.448 107.536 115.926 1.00 43.55  ? 203 GLY A CA  1 
ATOM 1103 C C   . GLY A 1 229 ? 127.476 108.218 116.862 1.00 43.55  ? 203 GLY A C   1 
ATOM 1104 O O   . GLY A 1 229 ? 126.990 109.304 116.530 1.00 43.55  ? 203 GLY A O   1 
ATOM 1105 N N   . HIS A 1 230 ? 127.180 107.624 118.018 1.00 39.76  ? 204 HIS A N   1 
ATOM 1106 C CA  . HIS A 1 230 ? 126.227 108.208 118.954 1.00 39.76  ? 204 HIS A CA  1 
ATOM 1107 C C   . HIS A 1 230 ? 126.828 109.290 119.840 1.00 39.76  ? 204 HIS A C   1 
ATOM 1108 O O   . HIS A 1 230 ? 126.071 110.008 120.497 1.00 39.76  ? 204 HIS A O   1 
ATOM 1109 C CB  . HIS A 1 230 ? 125.629 107.123 119.850 1.00 39.76  ? 204 HIS A CB  1 
ATOM 1110 C CG  . HIS A 1 230 ? 124.476 106.391 119.239 1.00 39.76  ? 204 HIS A CG  1 
ATOM 1111 N ND1 . HIS A 1 230 ? 124.521 105.857 117.969 1.00 39.76  ? 204 HIS A ND1 1 
ATOM 1112 C CD2 . HIS A 1 230 ? 123.249 106.096 119.728 1.00 39.76  ? 204 HIS A CD2 1 
ATOM 1113 C CE1 . HIS A 1 230 ? 123.369 105.268 117.702 1.00 39.76  ? 204 HIS A CE1 1 
ATOM 1114 N NE2 . HIS A 1 230 ? 122.580 105.400 118.752 1.00 39.76  ? 204 HIS A NE2 1 
ATOM 1115 N N   . SER A 1 231 ? 128.155 109.426 119.871 1.00 35.79  ? 205 SER A N   1 
ATOM 1116 C CA  . SER A 1 231 ? 128.797 110.306 120.845 1.00 35.79  ? 205 SER A CA  1 
ATOM 1117 C C   . SER A 1 231 ? 128.610 111.777 120.494 1.00 35.79  ? 205 SER A C   1 
ATOM 1118 O O   . SER A 1 231 ? 128.552 112.632 121.388 1.00 35.79  ? 205 SER A O   1 
ATOM 1119 C CB  . SER A 1 231 ? 130.280 109.962 120.946 1.00 35.79  ? 205 SER A CB  1 
ATOM 1120 O OG  . SER A 1 231 ? 130.904 110.037 119.678 1.00 35.79  ? 205 SER A OG  1 
ATOM 1121 N N   . SER A 1 232 ? 128.525 112.087 119.200 1.00 34.74  ? 206 SER A N   1 
ATOM 1122 C CA  . SER A 1 232 ? 128.309 113.465 118.770 1.00 34.74  ? 206 SER A CA  1 
ATOM 1123 C C   . SER A 1 232 ? 126.930 113.961 119.176 1.00 34.74  ? 206 SER A C   1 
ATOM 1124 O O   . SER A 1 232 ? 126.775 115.119 119.584 1.00 34.74  ? 206 SER A O   1 
ATOM 1125 C CB  . SER A 1 232 ? 128.492 113.567 117.259 1.00 34.74  ? 206 SER A CB  1 
ATOM 1126 O OG  . SER A 1 232 ? 127.599 112.699 116.587 1.00 34.74  ? 206 SER A OG  1 
ATOM 1127 N N   . LEU A 1 233 ? 125.920 113.091 119.074 1.00 34.64  ? 207 LEU A N   1 
ATOM 1128 C CA  . LEU A 1 233 ? 124.568 113.430 119.510 1.00 34.64  ? 207 LEU A CA  1 
ATOM 1129 C C   . LEU A 1 233 ? 124.522 113.689 121.006 1.00 34.64  ? 207 LEU A C   1 
ATOM 1130 O O   . LEU A 1 233 ? 123.867 114.636 121.459 1.00 34.64  ? 207 LEU A O   1 
ATOM 1131 C CB  . LEU A 1 233 ? 123.607 112.304 119.139 1.00 34.64  ? 207 LEU A CB  1 
ATOM 1132 C CG  . LEU A 1 233 ? 122.160 112.432 119.611 1.00 34.64  ? 207 LEU A CG  1 
ATOM 1133 C CD1 . LEU A 1 233 ? 121.375 113.346 118.695 1.00 34.64  ? 207 LEU A CD1 1 
ATOM 1134 C CD2 . LEU A 1 233 ? 121.506 111.068 119.710 1.00 34.64  ? 207 LEU A CD2 1 
ATOM 1135 N N   . TYR A 1 234 ? 125.231 112.867 121.783 1.00 33.21  ? 208 TYR A N   1 
ATOM 1136 C CA  . TYR A 1 234 ? 125.269 113.043 123.231 1.00 33.21  ? 208 TYR A CA  1 
ATOM 1137 C C   . TYR A 1 234 ? 125.962 114.341 123.609 1.00 33.21  ? 208 TYR A C   1 
ATOM 1138 O O   . TYR A 1 234 ? 125.509 115.041 124.516 1.00 33.21  ? 208 TYR A O   1 
ATOM 1139 C CB  . TYR A 1 234 ? 125.965 111.859 123.900 1.00 33.21  ? 208 TYR A CB  1 
ATOM 1140 C CG  . TYR A 1 234 ? 125.280 110.531 123.696 1.00 33.21  ? 208 TYR A CG  1 
ATOM 1141 C CD1 . TYR A 1 234 ? 123.910 110.454 123.485 1.00 33.21  ? 208 TYR A CD1 1 
ATOM 1142 C CD2 . TYR A 1 234 ? 126.004 109.351 123.726 1.00 33.21  ? 208 TYR A CD2 1 
ATOM 1143 C CE1 . TYR A 1 234 ? 123.286 109.242 123.296 1.00 33.21  ? 208 TYR A CE1 1 
ATOM 1144 C CE2 . TYR A 1 234 ? 125.387 108.133 123.541 1.00 33.21  ? 208 TYR A CE2 1 
ATOM 1145 C CZ  . TYR A 1 234 ? 124.029 108.086 123.327 1.00 33.21  ? 208 TYR A CZ  1 
ATOM 1146 O OH  . TYR A 1 234 ? 123.410 106.875 123.144 1.00 33.21  ? 208 TYR A OH  1 
ATOM 1147 N N   . LEU A 1 235 ? 127.047 114.690 122.913 1.00 33.67  ? 209 LEU A N   1 
ATOM 1148 C CA  . LEU A 1 235 ? 127.733 115.947 123.207 1.00 33.67  ? 209 LEU A CA  1 
ATOM 1149 C C   . LEU A 1 235 ? 126.893 117.156 122.803 1.00 33.67  ? 209 LEU A C   1 
ATOM 1150 O O   . LEU A 1 235 ? 126.913 118.185 123.487 1.00 33.67  ? 209 LEU A O   1 
ATOM 1151 C CB  . LEU A 1 235 ? 129.092 115.977 122.515 1.00 33.67  ? 209 LEU A CB  1 
ATOM 1152 C CG  . LEU A 1 235 ? 129.961 117.214 122.740 1.00 33.67  ? 209 LEU A CG  1 
ATOM 1153 C CD1 . LEU A 1 235 ? 130.091 117.567 124.206 1.00 33.67  ? 209 LEU A CD1 1 
ATOM 1154 C CD2 . LEU A 1 235 ? 131.307 116.976 122.151 1.00 33.67  ? 209 LEU A CD2 1 
ATOM 1155 N N   . GLY A 1 236 ? 126.151 117.053 121.700 1.00 33.65  ? 210 GLY A N   1 
ATOM 1156 C CA  . GLY A 1 236 ? 125.240 118.128 121.334 1.00 33.65  ? 210 GLY A CA  1 
ATOM 1157 C C   . GLY A 1 236 ? 124.118 118.309 122.339 1.00 33.65  ? 210 GLY A C   1 
ATOM 1158 O O   . GLY A 1 236 ? 123.739 119.438 122.665 1.00 33.65  ? 210 GLY A O   1 
ATOM 1159 N N   . ILE A 1 237 ? 123.597 117.197 122.869 1.00 32.98  ? 211 ILE A N   1 
ATOM 1160 C CA  . ILE A 1 237 ? 122.594 117.250 123.930 1.00 32.98  ? 211 ILE A CA  1 
ATOM 1161 C C   . ILE A 1 237 ? 123.183 117.857 125.201 1.00 32.98  ? 211 ILE A C   1 
ATOM 1162 O O   . ILE A 1 237 ? 122.535 118.673 125.866 1.00 32.98  ? 211 ILE A O   1 
ATOM 1163 C CB  . ILE A 1 237 ? 122.016 115.840 124.169 1.00 32.98  ? 211 ILE A CB  1 
ATOM 1164 C CG1 . ILE A 1 237 ? 121.074 115.449 123.032 1.00 32.98  ? 211 ILE A CG1 1 
ATOM 1165 C CG2 . ILE A 1 237 ? 121.271 115.739 125.491 1.00 32.98  ? 211 ILE A CG2 1 
ATOM 1166 C CD1 . ILE A 1 237 ? 120.645 114.004 123.085 1.00 32.98  ? 211 ILE A CD1 1 
ATOM 1167 N N   . LEU A 1 238 ? 124.426 117.494 125.538 1.00 33.57  ? 212 LEU A N   1 
ATOM 1168 C CA  . LEU A 1 238 ? 125.096 118.047 126.716 1.00 33.57  ? 212 LEU A CA  1 
ATOM 1169 C C   . LEU A 1 238 ? 125.298 119.550 126.591 1.00 33.57  ? 212 LEU A C   1 
ATOM 1170 O O   . LEU A 1 238 ? 125.030 120.301 127.533 1.00 33.57  ? 212 LEU A O   1 
ATOM 1171 C CB  . LEU A 1 238 ? 126.448 117.367 126.931 1.00 33.57  ? 212 LEU A CB  1 
ATOM 1172 C CG  . LEU A 1 238 ? 126.529 115.954 127.496 1.00 33.57  ? 212 LEU A CG  1 
ATOM 1173 C CD1 . LEU A 1 238 ? 127.925 115.692 127.988 1.00 33.57  ? 212 LEU A CD1 1 
ATOM 1174 C CD2 . LEU A 1 238 ? 125.546 115.779 128.600 1.00 33.57  ? 212 LEU A CD2 1 
ATOM 1175 N N   . ASN A 1 239 ? 125.748 120.008 125.423 1.00 35.01  ? 213 ASN A N   1 
ATOM 1176 C CA  . ASN A 1 239 ? 125.978 121.434 125.228 1.00 35.01  ? 213 ASN A CA  1 
ATOM 1177 C C   . ASN A 1 239 ? 124.673 122.206 125.105 1.00 35.01  ? 213 ASN A C   1 
ATOM 1178 O O   . ASN A 1 239 ? 124.649 123.415 125.356 1.00 35.01  ? 213 ASN A O   1 
ATOM 1179 C CB  . ASN A 1 239 ? 126.841 121.658 123.990 1.00 35.01  ? 213 ASN A CB  1 
ATOM 1180 C CG  . ASN A 1 239 ? 128.321 121.646 124.300 1.00 35.01  ? 213 ASN A CG  1 
ATOM 1181 O OD1 . ASN A 1 239 ? 128.776 122.295 125.240 1.00 35.01  ? 213 ASN A OD1 1 
ATOM 1182 N ND2 . ASN A 1 239 ? 129.084 120.913 123.502 1.00 35.01  ? 213 ASN A ND2 1 
ATOM 1183 N N   . ALA A 1 240 ? 123.588 121.544 124.696 1.00 35.71  ? 214 ALA A N   1 
ATOM 1184 C CA  . ALA A 1 240 ? 122.289 122.208 124.676 1.00 35.71  ? 214 ALA A CA  1 
ATOM 1185 C C   . ALA A 1 240 ? 121.715 122.346 126.081 1.00 35.71  ? 214 ALA A C   1 
ATOM 1186 O O   . ALA A 1 240 ? 121.220 123.414 126.455 1.00 35.71  ? 214 ALA A O   1 
ATOM 1187 C CB  . ALA A 1 240 ? 121.324 121.442 123.773 1.00 35.71  ? 214 ALA A CB  1 
ATOM 1188 N N   . ILE A 1 241 ? 121.781 121.277 126.879 1.00 34.91  ? 215 ILE A N   1 
ATOM 1189 C CA  . ILE A 1 241 ? 121.201 121.299 128.217 1.00 34.91  ? 215 ILE A CA  1 
ATOM 1190 C C   . ILE A 1 241 ? 122.114 122.061 129.180 1.00 34.91  ? 215 ILE A C   1 
ATOM 1191 O O   . ILE A 1 241 ? 121.665 122.532 130.228 1.00 34.91  ? 215 ILE A O   1 
ATOM 1192 C CB  . ILE A 1 241 ? 120.894 119.842 128.641 1.00 34.91  ? 215 ILE A CB  1 
ATOM 1193 C CG1 . ILE A 1 241 ? 119.891 119.229 127.658 1.00 34.91  ? 215 ILE A CG1 1 
ATOM 1194 C CG2 . ILE A 1 241 ? 120.216 119.761 130.007 1.00 34.91  ? 215 ILE A CG2 1 
ATOM 1195 C CD1 . ILE A 1 241 ? 119.358 117.848 128.040 1.00 34.91  ? 215 ILE A CD1 1 
ATOM 1196 N N   . ALA A 1 242 ? 123.374 122.293 128.806 1.00 35.89  ? 216 ALA A N   1 
ATOM 1197 C CA  . ALA A 1 242 ? 124.237 123.159 129.603 1.00 35.89  ? 216 ALA A CA  1 
ATOM 1198 C C   . ALA A 1 242 ? 123.803 124.620 129.571 1.00 35.89  ? 216 ALA A C   1 
ATOM 1199 O O   . ALA A 1 242 ? 124.281 125.409 130.390 1.00 35.89  ? 216 ALA A O   1 
ATOM 1200 C CB  . ALA A 1 242 ? 125.680 123.045 129.120 1.00 35.89  ? 216 ALA A CB  1 
ATOM 1201 N N   . MET A 1 243 ? 122.916 125.000 128.648 1.00 39.95  ? 217 MET A N   1 
ATOM 1202 C CA  . MET A 1 243 ? 122.402 126.361 128.589 1.00 39.95  ? 217 MET A CA  1 
ATOM 1203 C C   . MET A 1 243 ? 121.306 126.634 129.612 1.00 39.95  ? 217 MET A C   1 
ATOM 1204 O O   . MET A 1 243 ? 120.889 127.788 129.744 1.00 39.95  ? 217 MET A O   1 
ATOM 1205 C CB  . MET A 1 243 ? 121.888 126.660 127.181 1.00 39.95  ? 217 MET A CB  1 
ATOM 1206 C CG  . MET A 1 243 ? 122.920 126.440 126.086 1.00 39.95  ? 217 MET A CG  1 
ATOM 1207 S SD  . MET A 1 243 ? 124.351 127.534 126.191 1.00 39.95  ? 217 MET A SD  1 
ATOM 1208 C CE  . MET A 1 243 ? 123.572 129.136 126.402 1.00 39.95  ? 217 MET A CE  1 
ATOM 1209 N N   . ILE A 1 244 ? 120.823 125.611 130.323 1.00 38.25  ? 218 ILE A N   1 
ATOM 1210 C CA  . ILE A 1 244 ? 119.924 125.840 131.453 1.00 38.25  ? 218 ILE A CA  1 
ATOM 1211 C C   . ILE A 1 244 ? 120.663 126.553 132.580 1.00 38.25  ? 218 ILE A C   1 
ATOM 1212 O O   . ILE A 1 244 ? 120.078 127.358 133.316 1.00 38.25  ? 218 ILE A O   1 
ATOM 1213 C CB  . ILE A 1 244 ? 119.300 124.510 131.922 1.00 38.25  ? 218 ILE A CB  1 
ATOM 1214 C CG1 . ILE A 1 244 ? 118.735 123.726 130.736 1.00 38.25  ? 218 ILE A CG1 1 
ATOM 1215 C CG2 . ILE A 1 244 ? 118.213 124.736 132.960 1.00 38.25  ? 218 ILE A CG2 1 
ATOM 1216 C CD1 . ILE A 1 244 ? 117.484 124.318 130.129 1.00 38.25  ? 218 ILE A CD1 1 
ATOM 1217 N N   . GLY A 1 245 ? 121.962 126.286 132.713 1.00 36.60  ? 219 GLY A N   1 
ATOM 1218 C CA  . GLY A 1 245 ? 122.801 126.873 133.734 1.00 36.60  ? 219 GLY A CA  1 
ATOM 1219 C C   . GLY A 1 245 ? 122.903 128.390 133.751 1.00 36.60  ? 219 GLY A C   1 
ATOM 1220 O O   . GLY A 1 245 ? 122.743 129.005 134.807 1.00 36.60  ? 219 GLY A O   1 
ATOM 1221 N N   . PRO A 1 246 ? 123.205 129.024 132.610 1.00 37.40  ? 220 PRO A N   1 
ATOM 1222 C CA  . PRO A 1 246 ? 123.142 130.496 132.564 1.00 37.40  ? 220 PRO A CA  1 
ATOM 1223 C C   . PRO A 1 246 ? 121.758 131.081 132.799 1.00 37.40  ? 220 PRO A C   1 
ATOM 1224 O O   . PRO A 1 246 ? 121.665 132.194 133.328 1.00 37.40  ? 220 PRO A O   1 
ATOM 1225 C CB  . PRO A 1 246 ? 123.653 130.815 131.156 1.00 37.40  ? 220 PRO A CB  1 
ATOM 1226 C CG  . PRO A 1 246 ? 124.609 129.739 130.879 1.00 37.40  ? 220 PRO A CG  1 
ATOM 1227 C CD  . PRO A 1 246 ? 124.032 128.501 131.506 1.00 37.40  ? 220 PRO A CD  1 
ATOM 1228 N N   . ILE A 1 247 ? 120.687 130.379 132.422 1.00 38.70  ? 221 ILE A N   1 
ATOM 1229 C CA  . ILE A 1 247 ? 119.335 130.876 132.677 1.00 38.70  ? 221 ILE A CA  1 
ATOM 1230 C C   . ILE A 1 247 ? 119.077 130.957 134.177 1.00 38.70  ? 221 ILE A C   1 
ATOM 1231 O O   . ILE A 1 247 ? 118.642 131.996 134.696 1.00 38.70  ? 221 ILE A O   1 
ATOM 1232 C CB  . ILE A 1 247 ? 118.296 129.982 131.977 1.00 38.70  ? 221 ILE A CB  1 
ATOM 1233 C CG1 . ILE A 1 247 ? 118.461 130.056 130.461 1.00 38.70  ? 221 ILE A CG1 1 
ATOM 1234 C CG2 . ILE A 1 247 ? 116.888 130.395 132.363 1.00 38.70  ? 221 ILE A CG2 1 
ATOM 1235 C CD1 . ILE A 1 247 ? 117.581 129.089 129.718 1.00 38.70  ? 221 ILE A CD1 1 
ATOM 1236 N N   . ILE A 1 248 ? 119.405 129.876 134.894 1.00 36.50  ? 222 ILE A N   1 
ATOM 1237 C CA  . ILE A 1 248 ? 119.321 129.846 136.353 1.00 36.50  ? 222 ILE A CA  1 
ATOM 1238 C C   . ILE A 1 248 ? 120.263 130.877 136.962 1.00 36.50  ? 222 ILE A C   1 
ATOM 1239 O O   . ILE A 1 248 ? 119.919 131.547 137.941 1.00 36.50  ? 222 ILE A O   1 
ATOM 1240 C CB  . ILE A 1 248 ? 119.621 128.422 136.864 1.00 36.50  ? 222 ILE A CB  1 
ATOM 1241 C CG1 . ILE A 1 248 ? 118.580 127.435 136.337 1.00 36.50  ? 222 ILE A CG1 1 
ATOM 1242 C CG2 . ILE A 1 248 ? 119.648 128.358 138.378 1.00 36.50  ? 222 ILE A CG2 1 
ATOM 1243 C CD1 . ILE A 1 248 ? 118.983 125.985 136.489 1.00 36.50  ? 222 ILE A CD1 1 
ATOM 1244 N N   . GLY A 1 249 ? 121.436 131.062 136.349 1.00 37.85  ? 223 GLY A N   1 
ATOM 1245 C CA  . GLY A 1 249 ? 122.422 131.991 136.884 1.00 37.85  ? 223 GLY A CA  1 
ATOM 1246 C C   . GLY A 1 249 ? 121.973 133.438 136.851 1.00 37.85  ? 223 GLY A C   1 
ATOM 1247 O O   . GLY A 1 249 ? 121.999 134.124 137.873 1.00 37.85  ? 223 GLY A O   1 
ATOM 1248 N N   . PHE A 1 250 ? 121.527 133.917 135.683 1.00 39.97  ? 224 PHE A N   1 
ATOM 1249 C CA  . PHE A 1 250 ? 121.047 135.298 135.607 1.00 39.97  ? 224 PHE A CA  1 
ATOM 1250 C C   . PHE A 1 250 ? 119.721 135.487 136.337 1.00 39.97  ? 224 PHE A C   1 
ATOM 1251 O O   . PHE A 1 250 ? 119.492 136.553 136.927 1.00 39.97  ? 224 PHE A O   1 
ATOM 1252 C CB  . PHE A 1 250 ? 120.939 135.783 134.159 1.00 39.97  ? 224 PHE A CB  1 
ATOM 1253 C CG  . PHE A 1 250 ? 122.266 135.933 133.461 1.00 39.97  ? 224 PHE A CG  1 
ATOM 1254 C CD1 . PHE A 1 250 ? 123.041 137.062 133.679 1.00 39.97  ? 224 PHE A CD1 1 
ATOM 1255 C CD2 . PHE A 1 250 ? 122.713 134.992 132.550 1.00 39.97  ? 224 PHE A CD2 1 
ATOM 1256 C CE1 . PHE A 1 250 ? 124.257 137.225 133.037 1.00 39.97  ? 224 PHE A CE1 1 
ATOM 1257 C CE2 . PHE A 1 250 ? 123.928 135.145 131.904 1.00 39.97  ? 224 PHE A CE2 1 
ATOM 1258 C CZ  . PHE A 1 250 ? 124.699 136.265 132.147 1.00 39.97  ? 224 PHE A CZ  1 
ATOM 1259 N N   . THR A 1 251 ? 118.855 134.461 136.345 1.00 37.37  ? 225 THR A N   1 
ATOM 1260 C CA  . THR A 1 251 ? 117.594 134.551 137.079 1.00 37.37  ? 225 THR A CA  1 
ATOM 1261 C C   . THR A 1 251 ? 117.832 134.694 138.576 1.00 37.37  ? 225 THR A C   1 
ATOM 1262 O O   . THR A 1 251 ? 117.277 135.591 139.222 1.00 37.37  ? 225 THR A O   1 
ATOM 1263 C CB  . THR A 1 251 ? 116.739 133.318 136.792 1.00 37.37  ? 225 THR A CB  1 
ATOM 1264 O OG1 . THR A 1 251 ? 116.507 133.216 135.383 1.00 37.37  ? 225 THR A OG1 1 
ATOM 1265 C CG2 . THR A 1 251 ? 115.408 133.410 137.514 1.00 37.37  ? 225 THR A CG2 1 
ATOM 1266 N N   . LEU A 1 252 ? 118.704 133.855 139.135 1.00 36.93  ? 226 LEU A N   1 
ATOM 1267 C CA  . LEU A 1 252 ? 118.966 133.907 140.566 1.00 36.93  ? 226 LEU A CA  1 
ATOM 1268 C C   . LEU A 1 252 ? 119.845 135.094 140.931 1.00 36.93  ? 226 LEU A C   1 
ATOM 1269 O O   . LEU A 1 252 ? 119.749 135.609 142.047 1.00 36.93  ? 226 LEU A O   1 
ATOM 1270 C CB  . LEU A 1 252 ? 119.593 132.596 141.025 1.00 36.93  ? 226 LEU A CB  1 
ATOM 1271 C CG  . LEU A 1 252 ? 118.592 131.443 141.075 1.00 36.93  ? 226 LEU A CG  1 
ATOM 1272 C CD1 . LEU A 1 252 ? 119.228 130.229 141.686 1.00 36.93  ? 226 LEU A CD1 1 
ATOM 1273 C CD2 . LEU A 1 252 ? 117.340 131.827 141.848 1.00 36.93  ? 226 LEU A CD2 1 
ATOM 1274 N N   . GLY A 1 253 ? 120.689 135.559 140.008 1.00 38.86  ? 227 GLY A N   1 
ATOM 1275 C CA  . GLY A 1 253 ? 121.443 136.775 140.266 1.00 38.86  ? 227 GLY A CA  1 
ATOM 1276 C C   . GLY A 1 253 ? 120.553 137.998 140.363 1.00 38.86  ? 227 GLY A C   1 
ATOM 1277 O O   . GLY A 1 253 ? 120.688 138.805 141.286 1.00 38.86  ? 227 GLY A O   1 
ATOM 1278 N N   . SER A 1 254 ? 119.598 138.126 139.435 1.00 41.71  ? 228 SER A N   1 
ATOM 1279 C CA  . SER A 1 254 ? 118.646 139.230 139.502 1.00 41.71  ? 228 SER A CA  1 
ATOM 1280 C C   . SER A 1 254 ? 117.691 139.071 140.681 1.00 41.71  ? 228 SER A C   1 
ATOM 1281 O O   . SER A 1 254 ? 117.207 140.066 141.232 1.00 41.71  ? 228 SER A O   1 
ATOM 1282 C CB  . SER A 1 254 ? 117.871 139.331 138.189 1.00 41.71  ? 228 SER A CB  1 
ATOM 1283 O OG  . SER A 1 254 ? 117.022 140.465 138.180 1.00 41.71  ? 228 SER A OG  1 
ATOM 1284 N N   . LEU A 1 255 ? 117.410 137.828 141.084 1.00 38.49  ? 229 LEU A N   1 
ATOM 1285 C CA  . LEU A 1 255 ? 116.529 137.601 142.225 1.00 38.49  ? 229 LEU A CA  1 
ATOM 1286 C C   . LEU A 1 255 ? 117.206 137.960 143.541 1.00 38.49  ? 229 LEU A C   1 
ATOM 1287 O O   . LEU A 1 255 ? 116.599 138.608 144.401 1.00 38.49  ? 229 LEU A O   1 
ATOM 1288 C CB  . LEU A 1 255 ? 116.073 136.145 142.249 1.00 38.49  ? 229 LEU A CB  1 
ATOM 1289 C CG  . LEU A 1 255 ? 114.683 135.882 142.824 1.00 38.49  ? 229 LEU A CG  1 
ATOM 1290 C CD1 . LEU A 1 255 ? 113.620 136.558 141.973 1.00 38.49  ? 229 LEU A CD1 1 
ATOM 1291 C CD2 . LEU A 1 255 ? 114.426 134.391 142.928 1.00 38.49  ? 229 LEU A CD2 1 
ATOM 1292 N N   . PHE A 1 256 ? 118.459 137.546 143.717 1.00 34.48  ? 230 PHE A N   1 
ATOM 1293 C CA  . PHE A 1 256 ? 119.174 137.735 144.968 1.00 34.48  ? 230 PHE A CA  1 
ATOM 1294 C C   . PHE A 1 256 ? 119.916 139.061 145.036 1.00 34.48  ? 230 PHE A C   1 
ATOM 1295 O O   . PHE A 1 256 ? 120.439 139.401 146.100 1.00 34.48  ? 230 PHE A O   1 
ATOM 1296 C CB  . PHE A 1 256 ? 120.161 136.582 145.176 1.00 34.48  ? 230 PHE A CB  1 
ATOM 1297 C CG  . PHE A 1 256 ? 119.499 135.251 145.431 1.00 34.48  ? 230 PHE A CG  1 
ATOM 1298 C CD1 . PHE A 1 256 ? 118.353 135.169 146.191 1.00 34.48  ? 230 PHE A CD1 1 
ATOM 1299 C CD2 . PHE A 1 256 ? 120.022 134.086 144.907 1.00 34.48  ? 230 PHE A CD2 1 
ATOM 1300 C CE1 . PHE A 1 256 ? 117.744 133.953 146.426 1.00 34.48  ? 230 PHE A CE1 1 
ATOM 1301 C CE2 . PHE A 1 256 ? 119.423 132.871 145.135 1.00 34.48  ? 230 PHE A CE2 1 
ATOM 1302 C CZ  . PHE A 1 256 ? 118.282 132.804 145.897 1.00 34.48  ? 230 PHE A CZ  1 
ATOM 1303 N N   . SER A 1 257 ? 119.980 139.815 143.935 1.00 40.64  ? 231 SER A N   1 
ATOM 1304 C CA  . SER A 1 257 ? 120.568 141.148 143.996 1.00 40.64  ? 231 SER A CA  1 
ATOM 1305 C C   . SER A 1 257 ? 119.612 142.148 144.629 1.00 40.64  ? 231 SER A C   1 
ATOM 1306 O O   . SER A 1 257 ? 120.047 143.093 145.295 1.00 40.64  ? 231 SER A O   1 
ATOM 1307 C CB  . SER A 1 257 ? 120.968 141.606 142.596 1.00 40.64  ? 231 SER A CB  1 
ATOM 1308 O OG  . SER A 1 257 ? 121.398 142.954 142.605 1.00 40.64  ? 231 SER A OG  1 
ATOM 1309 N N   . LYS A 1 258 ? 118.306 141.963 144.423 1.00 42.77  ? 232 LYS A N   1 
ATOM 1310 C CA  . LYS A 1 258 ? 117.323 142.875 144.998 1.00 42.77  ? 232 LYS A CA  1 
ATOM 1311 C C   . LYS A 1 258 ? 117.186 142.679 146.501 1.00 42.77  ? 232 LYS A C   1 
ATOM 1312 O O   . LYS A 1 258 ? 116.764 143.601 147.207 1.00 42.77  ? 232 LYS A O   1 
ATOM 1313 C CB  . LYS A 1 258 ? 115.969 142.680 144.323 1.00 42.77  ? 232 LYS A CB  1 
ATOM 1314 C CG  . LYS A 1 258 ? 115.926 143.092 142.864 1.00 42.77  ? 232 LYS A CG  1 
ATOM 1315 C CD  . LYS A 1 258 ? 114.601 142.696 142.238 1.00 42.77  ? 232 LYS A CD  1 
ATOM 1316 C CE  . LYS A 1 258 ? 113.454 143.501 142.830 1.00 42.77  ? 232 LYS A CE  1 
ATOM 1317 N NZ  . LYS A 1 258 ? 112.157 143.193 142.167 1.00 42.77  ? 232 LYS A NZ  1 
ATOM 1318 N N   . MET A 1 259 ? 117.510 141.490 147.001 1.00 39.26  ? 233 MET A N   1 
ATOM 1319 C CA  . MET A 1 259 ? 117.502 141.248 148.435 1.00 39.26  ? 233 MET A CA  1 
ATOM 1320 C C   . MET A 1 259 ? 118.698 141.925 149.087 1.00 39.26  ? 233 MET A C   1 
ATOM 1321 O O   . MET A 1 259 ? 119.764 142.047 148.482 1.00 39.26  ? 233 MET A O   1 
ATOM 1322 C CB  . MET A 1 259 ? 117.525 139.748 148.717 1.00 39.26  ? 233 MET A CB  1 
ATOM 1323 C CG  . MET A 1 259 ? 116.351 139.003 148.117 1.00 39.26  ? 233 MET A CG  1 
ATOM 1324 S SD  . MET A 1 259 ? 116.436 137.213 148.308 1.00 39.26  ? 233 MET A SD  1 
ATOM 1325 C CE  . MET A 1 259 ? 116.547 137.043 150.078 1.00 39.26  ? 233 MET A CE  1 
ATOM 1326 N N   . TYR A 1 260 ? 118.514 142.382 150.322 1.00 42.56  ? 234 TYR A N   1 
ATOM 1327 C CA  . TYR A 1 260 ? 119.623 142.957 151.067 1.00 42.56  ? 234 TYR A CA  1 
ATOM 1328 C C   . TYR A 1 260 ? 120.580 141.864 151.527 1.00 42.56  ? 234 TYR A C   1 
ATOM 1329 O O   . TYR A 1 260 ? 120.197 140.702 151.688 1.00 42.56  ? 234 TYR A O   1 
ATOM 1330 C CB  . TYR A 1 260 ? 119.113 143.747 152.270 1.00 42.56  ? 234 TYR A CB  1 
ATOM 1331 C CG  . TYR A 1 260 ? 120.136 144.701 152.830 1.00 42.56  ? 234 TYR A CG  1 
ATOM 1332 C CD1 . TYR A 1 260 ? 120.954 145.438 151.986 1.00 42.56  ? 234 TYR A CD1 1 
ATOM 1333 C CD2 . TYR A 1 260 ? 120.302 144.845 154.198 1.00 42.56  ? 234 TYR A CD2 1 
ATOM 1334 C CE1 . TYR A 1 260 ? 121.897 146.302 152.487 1.00 42.56  ? 234 TYR A CE1 1 
ATOM 1335 C CE2 . TYR A 1 260 ? 121.243 145.704 154.710 1.00 42.56  ? 234 TYR A CE2 1 
ATOM 1336 C CZ  . TYR A 1 260 ? 122.037 146.432 153.852 1.00 42.56  ? 234 TYR A CZ  1 
ATOM 1337 O OH  . TYR A 1 260 ? 122.978 147.294 154.363 1.00 42.56  ? 234 TYR A OH  1 
ATOM 1338 N N   . VAL A 1 261 ? 121.843 142.251 151.732 1.00 40.22  ? 235 VAL A N   1 
ATOM 1339 C CA  . VAL A 1 261 ? 122.882 141.293 152.103 1.00 40.22  ? 235 VAL A CA  1 
ATOM 1340 C C   . VAL A 1 261 ? 122.652 140.760 153.514 1.00 40.22  ? 235 VAL A C   1 
ATOM 1341 O O   . VAL A 1 261 ? 122.973 139.602 153.810 1.00 40.22  ? 235 VAL A O   1 
ATOM 1342 C CB  . VAL A 1 261 ? 124.278 141.937 151.921 1.00 40.22  ? 235 VAL A CB  1 
ATOM 1343 C CG1 . VAL A 1 261 ? 124.476 143.147 152.821 1.00 40.22  ? 235 VAL A CG1 1 
ATOM 1344 C CG2 . VAL A 1 261 ? 125.396 140.920 152.102 1.00 40.22  ? 235 VAL A CG2 1 
ATOM 1345 N N   . ASP A 1 262 ? 122.035 141.560 154.385 1.00 42.45  ? 236 ASP A N   1 
ATOM 1346 C CA  . ASP A 1 262 ? 121.722 141.144 155.744 1.00 42.45  ? 236 ASP A CA  1 
ATOM 1347 C C   . ASP A 1 262 ? 120.290 140.655 155.881 1.00 42.45  ? 236 ASP A C   1 
ATOM 1348 O O   . ASP A 1 262 ? 119.645 140.922 156.903 1.00 42.45  ? 236 ASP A O   1 
ATOM 1349 C CB  . ASP A 1 262 ? 121.990 142.287 156.721 1.00 42.45  ? 236 ASP A CB  1 
ATOM 1350 C CG  . ASP A 1 262 ? 123.387 142.850 156.589 1.00 42.45  ? 236 ASP A CG  1 
ATOM 1351 O OD1 . ASP A 1 262 ? 124.354 142.061 156.625 1.00 42.45  ? 236 ASP A OD1 1 
ATOM 1352 O OD2 . ASP A 1 262 ? 123.520 144.084 156.453 1.00 42.45  ? 236 ASP A OD2 1 
ATOM 1353 N N   . ILE A 1 263 ? 119.769 139.974 154.855 1.00 40.27  ? 237 ILE A N   1 
ATOM 1354 C CA  . ILE A 1 263 ? 118.432 139.399 154.918 1.00 40.27  ? 237 ILE A CA  1 
ATOM 1355 C C   . ILE A 1 263 ? 118.403 138.306 155.980 1.00 40.27  ? 237 ILE A C   1 
ATOM 1356 O O   . ILE A 1 263 ? 119.358 137.535 156.140 1.00 40.27  ? 237 ILE A O   1 
ATOM 1357 C CB  . ILE A 1 263 ? 118.003 138.904 153.522 1.00 40.27  ? 237 ILE A CB  1 
ATOM 1358 C CG1 . ILE A 1 263 ? 116.510 138.576 153.471 1.00 40.27  ? 237 ILE A CG1 1 
ATOM 1359 C CG2 . ILE A 1 263 ? 118.863 137.747 152.997 1.00 40.27  ? 237 ILE A CG2 1 
ATOM 1360 C CD1 . ILE A 1 263 ? 115.626 139.763 153.642 1.00 40.27  ? 237 ILE A CD1 1 
ATOM 1361 N N   . GLY A 1 264 ? 117.344 138.300 156.782 1.00 43.33  ? 238 GLY A N   1 
ATOM 1362 C CA  . GLY A 1 264 ? 117.228 137.372 157.882 1.00 43.33  ? 238 GLY A CA  1 
ATOM 1363 C C   . GLY A 1 264 ? 117.996 137.757 159.129 1.00 43.33  ? 238 GLY A C   1 
ATOM 1364 O O   . GLY A 1 264 ? 117.924 137.032 160.130 1.00 43.33  ? 238 GLY A O   1 
ATOM 1365 N N   . TYR A 1 265 ? 118.728 138.872 159.105 1.00 40.55  ? 239 TYR A N   1 
ATOM 1366 C CA  . TYR A 1 265 ? 119.503 139.317 160.250 1.00 40.55  ? 239 TYR A CA  1 
ATOM 1367 C C   . TYR A 1 265 ? 119.060 140.661 160.799 1.00 40.55  ? 239 TYR A C   1 
ATOM 1368 O O   . TYR A 1 265 ? 119.242 140.908 161.994 1.00 40.55  ? 239 TYR A O   1 
ATOM 1369 C CB  . TYR A 1 265 ? 120.992 139.404 159.889 1.00 40.55  ? 239 TYR A CB  1 
ATOM 1370 C CG  . TYR A 1 265 ? 121.709 138.075 159.871 1.00 40.55  ? 239 TYR A CG  1 
ATOM 1371 C CD1 . TYR A 1 265 ? 122.045 137.433 161.053 1.00 40.55  ? 239 TYR A CD1 1 
ATOM 1372 C CD2 . TYR A 1 265 ? 122.056 137.468 158.674 1.00 40.55  ? 239 TYR A CD2 1 
ATOM 1373 C CE1 . TYR A 1 265 ? 122.703 136.220 161.042 1.00 40.55  ? 239 TYR A CE1 1 
ATOM 1374 C CE2 . TYR A 1 265 ? 122.715 136.256 158.654 1.00 40.55  ? 239 TYR A CE2 1 
ATOM 1375 C CZ  . TYR A 1 265 ? 123.036 135.638 159.841 1.00 40.55  ? 239 TYR A CZ  1 
ATOM 1376 O OH  . TYR A 1 265 ? 123.691 134.431 159.830 1.00 40.55  ? 239 TYR A OH  1 
ATOM 1377 N N   . VAL A 1 266 ? 118.486 141.528 159.967 1.00 45.66  ? 240 VAL A N   1 
ATOM 1378 C CA  . VAL A 1 266 ? 118.070 142.856 160.391 1.00 45.66  ? 240 VAL A CA  1 
ATOM 1379 C C   . VAL A 1 266 ? 116.593 143.039 160.077 1.00 45.66  ? 240 VAL A C   1 
ATOM 1380 O O   . VAL A 1 266 ? 115.996 142.289 159.303 1.00 45.66  ? 240 VAL A O   1 
ATOM 1381 C CB  . VAL A 1 266 ? 118.894 143.972 159.716 1.00 45.66  ? 240 VAL A CB  1 
ATOM 1382 C CG1 . VAL A 1 266 ? 120.353 143.879 160.118 1.00 45.66  ? 240 VAL A CG1 1 
ATOM 1383 C CG2 . VAL A 1 266 ? 118.745 143.896 158.211 1.00 45.66  ? 240 VAL A CG2 1 
ATOM 1384 N N   . ASP A 1 267 ? 116.004 144.051 160.708 1.00 55.80  ? 241 ASP A N   1 
ATOM 1385 C CA  . ASP A 1 267 ? 114.658 144.481 160.356 1.00 55.80  ? 241 ASP A CA  1 
ATOM 1386 C C   . ASP A 1 267 ? 114.722 145.295 159.070 1.00 55.80  ? 241 ASP A C   1 
ATOM 1387 O O   . ASP A 1 267 ? 115.448 146.292 158.994 1.00 55.80  ? 241 ASP A O   1 
ATOM 1388 C CB  . ASP A 1 267 ? 114.053 145.301 161.492 1.00 55.80  ? 241 ASP A CB  1 
ATOM 1389 C CG  . ASP A 1 267 ? 112.557 145.492 161.344 1.00 55.80  ? 241 ASP A CG  1 
ATOM 1390 O OD1 . ASP A 1 267 ? 111.806 144.524 161.585 1.00 55.80  ? 241 ASP A OD1 1 
ATOM 1391 O OD2 . ASP A 1 267 ? 112.131 146.613 160.992 1.00 55.80  ? 241 ASP A OD2 1 
ATOM 1392 N N   . LEU A 1 268 ? 113.962 144.873 158.058 1.00 53.75  ? 242 LEU A N   1 
ATOM 1393 C CA  . LEU A 1 268 ? 114.119 145.431 156.718 1.00 53.75  ? 242 LEU A CA  1 
ATOM 1394 C C   . LEU A 1 268 ? 113.483 146.805 156.571 1.00 53.75  ? 242 LEU A C   1 
ATOM 1395 O O   . LEU A 1 268 ? 113.753 147.493 155.582 1.00 53.75  ? 242 LEU A O   1 
ATOM 1396 C CB  . LEU A 1 268 ? 113.538 144.484 155.664 1.00 53.75  ? 242 LEU A CB  1 
ATOM 1397 C CG  . LEU A 1 268 ? 114.362 143.306 155.127 1.00 53.75  ? 242 LEU A CG  1 
ATOM 1398 C CD1 . LEU A 1 268 ? 115.586 143.821 154.391 1.00 53.75  ? 242 LEU A CD1 1 
ATOM 1399 C CD2 . LEU A 1 268 ? 114.756 142.287 156.187 1.00 53.75  ? 242 LEU A CD2 1 
ATOM 1400 N N   . SER A 1 269 ? 112.641 147.217 157.521 1.00 56.93  ? 243 SER A N   1 
ATOM 1401 C CA  . SER A 1 269 ? 112.092 148.567 157.481 1.00 56.93  ? 243 SER A CA  1 
ATOM 1402 C C   . SER A 1 269 ? 113.152 149.608 157.811 1.00 56.93  ? 243 SER A C   1 
ATOM 1403 O O   . SER A 1 269 ? 113.051 150.758 157.371 1.00 56.93  ? 243 SER A O   1 
ATOM 1404 C CB  . SER A 1 269 ? 110.915 148.681 158.448 1.00 56.93  ? 243 SER A CB  1 
ATOM 1405 O OG  . SER A 1 269 ? 111.363 148.999 159.753 1.00 56.93  ? 243 SER A OG  1 
ATOM 1406 N N   . THR A 1 270 ? 114.174 149.224 158.578 1.00 56.73  ? 244 THR A N   1 
ATOM 1407 C CA  . THR A 1 270 ? 115.245 150.147 158.932 1.00 56.73  ? 244 THR A CA  1 
ATOM 1408 C C   . THR A 1 270 ? 116.211 150.397 157.782 1.00 56.73  ? 244 THR A C   1 
ATOM 1409 O O   . THR A 1 270 ? 116.981 151.360 157.837 1.00 56.73  ? 244 THR A O   1 
ATOM 1410 C CB  . THR A 1 270 ? 116.017 149.612 160.138 1.00 56.73  ? 244 THR A CB  1 
ATOM 1411 O OG1 . THR A 1 270 ? 116.559 148.324 159.821 1.00 56.73  ? 244 THR A OG1 1 
ATOM 1412 C CG2 . THR A 1 270 ? 115.100 149.487 161.342 1.00 56.73  ? 244 THR A CG2 1 
ATOM 1413 N N   . ILE A 1 271 ? 116.197 149.556 156.754 1.00 54.23  ? 245 ILE A N   1 
ATOM 1414 C CA  . ILE A 1 271 ? 117.121 149.703 155.635 1.00 54.23  ? 245 ILE A CA  1 
ATOM 1415 C C   . ILE A 1 271 ? 116.565 150.758 154.688 1.00 54.23  ? 245 ILE A C   1 
ATOM 1416 O O   . ILE A 1 271 ? 115.470 150.599 154.140 1.00 54.23  ? 245 ILE A O   1 
ATOM 1417 C CB  . ILE A 1 271 ? 117.332 148.367 154.910 1.00 54.23  ? 245 ILE A CB  1 
ATOM 1418 C CG1 . ILE A 1 271 ? 117.603 147.245 155.914 1.00 54.23  ? 245 ILE A CG1 1 
ATOM 1419 C CG2 . ILE A 1 271 ? 118.479 148.479 153.929 1.00 54.23  ? 245 ILE A CG2 1 
ATOM 1420 C CD1 . ILE A 1 271 ? 118.838 147.452 156.764 1.00 54.23  ? 245 ILE A CD1 1 
ATOM 1421 N N   . ARG A 1 272 ? 117.323 151.833 154.487 1.00 55.62  ? 246 ARG A N   1 
ATOM 1422 C CA  . ARG A 1 272 ? 116.860 152.959 153.689 1.00 55.62  ? 246 ARG A CA  1 
ATOM 1423 C C   . ARG A 1 272 ? 117.311 152.898 152.238 1.00 55.62  ? 246 ARG A C   1 
ATOM 1424 O O   . ARG A 1 272 ? 116.621 153.425 151.361 1.00 55.62  ? 246 ARG A O   1 
ATOM 1425 C CB  . ARG A 1 272 ? 117.336 154.276 154.308 1.00 55.62  ? 246 ARG A CB  1 
ATOM 1426 C CG  . ARG A 1 272 ? 116.878 154.496 155.738 1.00 55.62  ? 246 ARG A CG  1 
ATOM 1427 C CD  . ARG A 1 272 ? 117.346 155.845 156.256 1.00 55.62  ? 246 ARG A CD  1 
ATOM 1428 N NE  . ARG A 1 272 ? 116.861 156.120 157.603 1.00 55.62  ? 246 ARG A NE  1 
ATOM 1429 C CZ  . ARG A 1 272 ? 117.488 156.891 158.481 1.00 55.62  ? 246 ARG A CZ  1 
ATOM 1430 N NH1 . ARG A 1 272 ? 118.637 157.479 158.188 1.00 55.62  ? 246 ARG A NH1 1 
ATOM 1431 N NH2 . ARG A 1 272 ? 116.948 157.080 159.682 1.00 55.62  ? 246 ARG A NH2 1 
ATOM 1432 N N   . ILE A 1 273 ? 118.451 152.265 151.960 1.00 50.68  ? 247 ILE A N   1 
ATOM 1433 C CA  . ILE A 1 273 ? 119.021 152.318 150.621 1.00 50.68  ? 247 ILE A CA  1 
ATOM 1434 C C   . ILE A 1 273 ? 118.275 151.377 149.681 1.00 50.68  ? 247 ILE A C   1 
ATOM 1435 O O   . ILE A 1 273 ? 117.699 150.362 150.094 1.00 50.68  ? 247 ILE A O   1 
ATOM 1436 C CB  . ILE A 1 273 ? 120.525 151.994 150.663 1.00 50.68  ? 247 ILE A CB  1 
ATOM 1437 C CG1 . ILE A 1 273 ? 120.771 150.674 151.391 1.00 50.68  ? 247 ILE A CG1 1 
ATOM 1438 C CG2 . ILE A 1 273 ? 121.290 153.120 151.327 1.00 50.68  ? 247 ILE A CG2 1 
ATOM 1439 C CD1 . ILE A 1 273 ? 122.200 150.209 151.319 1.00 50.68  ? 247 ILE A CD1 1 
ATOM 1440 N N   . THR A 1 274 ? 118.282 151.728 148.405 1.00 51.92  ? 248 THR A N   1 
ATOM 1441 C CA  . THR A 1 274 ? 117.642 151.007 147.321 1.00 51.92  ? 248 THR A CA  1 
ATOM 1442 C C   . THR A 1 274 ? 118.682 150.216 146.536 1.00 51.92  ? 248 THR A C   1 
ATOM 1443 O O   . THR A 1 274 ? 119.888 150.433 146.691 1.00 51.92  ? 248 THR A O   1 
ATOM 1444 C CB  . THR A 1 274 ? 116.916 151.998 146.399 1.00 51.92  ? 248 THR A CB  1 
ATOM 1445 O OG1 . THR A 1 274 ? 117.865 152.908 145.831 1.00 51.92  ? 248 THR A OG1 1 
ATOM 1446 C CG2 . THR A 1 274 ? 115.877 152.783 147.178 1.00 51.92  ? 248 THR A CG2 1 
ATOM 1447 N N   . PRO A 1 275 ? 118.256 149.257 145.702 1.00 50.70  ? 249 PRO A N   1 
ATOM 1448 C CA  . PRO A 1 275 ? 119.209 148.633 144.767 1.00 50.70  ? 249 PRO A CA  1 
ATOM 1449 C C   . PRO A 1 275 ? 119.801 149.588 143.739 1.00 50.70  ? 249 PRO A C   1 
ATOM 1450 O O   . PRO A 1 275 ? 120.842 149.269 143.153 1.00 50.70  ? 249 PRO A O   1 
ATOM 1451 C CB  . PRO A 1 275 ? 118.374 147.537 144.099 1.00 50.70  ? 249 PRO A CB  1 
ATOM 1452 C CG  . PRO A 1 275 ? 117.397 147.163 145.131 1.00 50.70  ? 249 PRO A CG  1 
ATOM 1453 C CD  . PRO A 1 275 ? 117.044 148.428 145.855 1.00 50.70  ? 249 PRO A CD  1 
ATOM 1454 N N   . THR A 1 276 ? 119.175 150.738 143.491 1.00 53.11  ? 250 THR A N   1 
ATOM 1455 C CA  . THR A 1 276 ? 119.754 151.751 142.620 1.00 53.11  ? 250 THR A CA  1 
ATOM 1456 C C   . THR A 1 276 ? 120.814 152.596 143.315 1.00 53.11  ? 250 THR A C   1 
ATOM 1457 O O   . THR A 1 276 ? 121.490 153.383 142.644 1.00 53.11  ? 250 THR A O   1 
ATOM 1458 C CB  . THR A 1 276 ? 118.655 152.664 142.079 1.00 53.11  ? 250 THR A CB  1 
ATOM 1459 O OG1 . THR A 1 276 ? 118.068 153.394 143.162 1.00 53.11  ? 250 THR A OG1 1 
ATOM 1460 C CG2 . THR A 1 276 ? 117.578 151.841 141.392 1.00 53.11  ? 250 THR A CG2 1 
ATOM 1461 N N   . ASP A 1 277 ? 120.968 152.460 144.629 1.00 54.23  ? 251 ASP A N   1 
ATOM 1462 C CA  . ASP A 1 277 ? 121.946 153.244 145.369 1.00 54.23  ? 251 ASP A CA  1 
ATOM 1463 C C   . ASP A 1 277 ? 123.354 152.709 145.122 1.00 54.23  ? 251 ASP A C   1 
ATOM 1464 O O   . ASP A 1 277 ? 123.555 151.520 144.859 1.00 54.23  ? 251 ASP A O   1 
ATOM 1465 C CB  . ASP A 1 277 ? 121.609 153.222 146.862 1.00 54.23  ? 251 ASP A CB  1 
ATOM 1466 C CG  . ASP A 1 277 ? 122.456 154.175 147.672 1.00 54.23  ? 251 ASP A CG  1 
ATOM 1467 O OD1 . ASP A 1 277 ? 122.224 155.399 147.581 1.00 54.23  ? 251 ASP A OD1 1 
ATOM 1468 O OD2 . ASP A 1 277 ? 123.347 153.702 148.406 1.00 54.23  ? 251 ASP A OD2 1 
ATOM 1469 N N   . SER A 1 278 ? 124.340 153.606 145.204 1.00 53.33  ? 252 SER A N   1 
ATOM 1470 C CA  . SER A 1 278 ? 125.720 153.239 144.910 1.00 53.33  ? 252 SER A CA  1 
ATOM 1471 C C   . SER A 1 278 ? 126.362 152.414 146.016 1.00 53.33  ? 252 SER A C   1 
ATOM 1472 O O   . SER A 1 278 ? 127.428 151.832 145.794 1.00 53.33  ? 252 SER A O   1 
ATOM 1473 C CB  . SER A 1 278 ? 126.552 154.496 144.660 1.00 53.33  ? 252 SER A CB  1 
ATOM 1474 O OG  . SER A 1 278 ? 126.325 155.462 145.670 1.00 53.33  ? 252 SER A OG  1 
ATOM 1475 N N   . ARG A 1 279 ? 125.754 152.358 147.198 1.00 51.86  ? 253 ARG A N   1 
ATOM 1476 C CA  . ARG A 1 279 ? 126.270 151.577 148.313 1.00 51.86  ? 253 ARG A CA  1 
ATOM 1477 C C   . ARG A 1 279 ? 125.510 150.275 148.522 1.00 51.86  ? 253 ARG A C   1 
ATOM 1478 O O   . ARG A 1 279 ? 125.667 149.642 149.568 1.00 51.86  ? 253 ARG A O   1 
ATOM 1479 C CB  . ARG A 1 279 ? 126.236 152.407 149.596 1.00 51.86  ? 253 ARG A CB  1 
ATOM 1480 C CG  . ARG A 1 279 ? 126.550 153.872 149.390 1.00 51.86  ? 253 ARG A CG  1 
ATOM 1481 C CD  . ARG A 1 279 ? 126.245 154.674 150.637 1.00 51.86  ? 253 ARG A CD  1 
ATOM 1482 N NE  . ARG A 1 279 ? 124.822 154.967 150.760 1.00 51.86  ? 253 ARG A NE  1 
ATOM 1483 C CZ  . ARG A 1 279 ? 124.322 155.946 151.501 1.00 51.86  ? 253 ARG A CZ  1 
ATOM 1484 N NH1 . ARG A 1 279 ? 125.103 156.743 152.211 1.00 51.86  ? 253 ARG A NH1 1 
ATOM 1485 N NH2 . ARG A 1 279 ? 123.006 156.129 151.530 1.00 51.86  ? 253 ARG A NH2 1 
ATOM 1486 N N   . TRP A 1 280 ? 124.685 149.868 147.562 1.00 44.16  ? 254 TRP A N   1 
ATOM 1487 C CA  . TRP A 1 280 ? 123.877 148.671 147.733 1.00 44.16  ? 254 TRP A CA  1 
ATOM 1488 C C   . TRP A 1 280 ? 124.720 147.416 147.565 1.00 44.16  ? 254 TRP A C   1 
ATOM 1489 O O   . TRP A 1 280 ? 125.504 147.293 146.621 1.00 44.16  ? 254 TRP A O   1 
ATOM 1490 C CB  . TRP A 1 280 ? 122.726 148.654 146.733 1.00 44.16  ? 254 TRP A CB  1 
ATOM 1491 C CG  . TRP A 1 280 ? 121.860 147.444 146.849 1.00 44.16  ? 254 TRP A CG  1 
ATOM 1492 C CD1 . TRP A 1 280 ? 121.917 146.317 146.084 1.00 44.16  ? 254 TRP A CD1 1 
ATOM 1493 C CD2 . TRP A 1 280 ? 120.796 147.240 147.782 1.00 44.16  ? 254 TRP A CD2 1 
ATOM 1494 N NE1 . TRP A 1 280 ? 120.959 145.422 146.487 1.00 44.16  ? 254 TRP A NE1 1 
ATOM 1495 C CE2 . TRP A 1 280 ? 120.256 145.967 147.527 1.00 44.16  ? 254 TRP A CE2 1 
ATOM 1496 C CE3 . TRP A 1 280 ? 120.249 148.010 148.811 1.00 44.16  ? 254 TRP A CE3 1 
ATOM 1497 C CZ2 . TRP A 1 280 ? 119.199 145.446 148.263 1.00 44.16  ? 254 TRP A CZ2 1 
ATOM 1498 C CZ3 . TRP A 1 280 ? 119.199 147.492 149.539 1.00 44.16  ? 254 TRP A CZ3 1 
ATOM 1499 C CH2 . TRP A 1 280 ? 118.684 146.223 149.262 1.00 44.16  ? 254 TRP A CH2 1 
ATOM 1500 N N   . VAL A 1 281 ? 124.554 146.479 148.494 1.00 41.40  ? 255 VAL A N   1 
ATOM 1501 C CA  . VAL A 1 281 ? 125.178 145.166 148.412 1.00 41.40  ? 255 VAL A CA  1 
ATOM 1502 C C   . VAL A 1 281 ? 124.056 144.145 148.519 1.00 41.40  ? 255 VAL A C   1 
ATOM 1503 O O   . VAL A 1 281 ? 123.343 144.109 149.526 1.00 41.40  ? 255 VAL A O   1 
ATOM 1504 C CB  . VAL A 1 281 ? 126.224 144.937 149.511 1.00 41.40  ? 255 VAL A CB  1 
ATOM 1505 C CG1 . VAL A 1 281 ? 126.734 143.511 149.461 1.00 41.40  ? 255 VAL A CG1 1 
ATOM 1506 C CG2 . VAL A 1 281 ? 127.374 145.912 149.361 1.00 41.40  ? 255 VAL A CG2 1 
ATOM 1507 N N   . GLY A 1 282 ? 123.890 143.326 147.486 1.00 39.14  ? 256 GLY A N   1 
ATOM 1508 C CA  . GLY A 1 282 ? 122.880 142.294 147.496 1.00 39.14  ? 256 GLY A CA  1 
ATOM 1509 C C   . GLY A 1 282 ? 123.353 141.042 148.196 1.00 39.14  ? 256 GLY A C   1 
ATOM 1510 O O   . GLY A 1 282 ? 124.465 140.958 148.712 1.00 39.14  ? 256 GLY A O   1 
ATOM 1511 N N   . ALA A 1 283 ? 122.488 140.029 148.188 1.00 34.48  ? 257 ALA A N   1 
ATOM 1512 C CA  . ALA A 1 283 ? 122.790 138.750 148.828 1.00 34.48  ? 257 ALA A CA  1 
ATOM 1513 C C   . ALA A 1 283 ? 123.645 137.895 147.892 1.00 34.48  ? 257 ALA A C   1 
ATOM 1514 O O   . ALA A 1 283 ? 123.209 136.888 147.333 1.00 34.48  ? 257 ALA A O   1 
ATOM 1515 C CB  . ALA A 1 283 ? 121.506 138.038 149.223 1.00 34.48  ? 257 ALA A CB  1 
ATOM 1516 N N   . TRP A 1 284 ? 124.903 138.321 147.742 1.00 41.75  ? 258 TRP A N   1 
ATOM 1517 C CA  . TRP A 1 284 ? 125.863 137.611 146.901 1.00 41.75  ? 258 TRP A CA  1 
ATOM 1518 C C   . TRP A 1 284 ? 126.198 136.236 147.459 1.00 41.75  ? 258 TRP A C   1 
ATOM 1519 O O   . TRP A 1 284 ? 126.558 135.329 146.703 1.00 41.75  ? 258 TRP A O   1 
ATOM 1520 C CB  . TRP A 1 284 ? 127.141 138.438 146.769 1.00 41.75  ? 258 TRP A CB  1 
ATOM 1521 C CG  . TRP A 1 284 ? 127.778 138.725 148.095 1.00 41.75  ? 258 TRP A CG  1 
ATOM 1522 C CD1 . TRP A 1 284 ? 127.519 139.780 148.914 1.00 41.75  ? 258 TRP A CD1 1 
ATOM 1523 C CD2 . TRP A 1 284 ? 128.769 137.934 148.765 1.00 41.75  ? 258 TRP A CD2 1 
ATOM 1524 N NE1 . TRP A 1 284 ? 128.285 139.700 150.047 1.00 41.75  ? 258 TRP A NE1 1 
ATOM 1525 C CE2 . TRP A 1 284 ? 129.061 138.574 149.980 1.00 41.75  ? 258 TRP A CE2 1 
ATOM 1526 C CE3 . TRP A 1 284 ? 129.437 136.747 148.453 1.00 41.75  ? 258 TRP A CE3 1 
ATOM 1527 C CZ2 . TRP A 1 284 ? 129.992 138.071 150.881 1.00 41.75  ? 258 TRP A CZ2 1 
ATOM 1528 C CZ3 . TRP A 1 284 ? 130.357 136.249 149.349 1.00 41.75  ? 258 TRP A CZ3 1 
ATOM 1529 C CH2 . TRP A 1 284 ? 130.627 136.909 150.547 1.00 41.75  ? 258 TRP A CH2 1 
ATOM 1530 N N   . TRP A 1 285 ? 126.110 136.077 148.781 1.00 43.93  ? 259 TRP A N   1 
ATOM 1531 C CA  . TRP A 1 285 ? 126.394 134.801 149.422 1.00 43.93  ? 259 TRP A CA  1 
ATOM 1532 C C   . TRP A 1 285 ? 125.344 133.756 149.081 1.00 43.93  ? 259 TRP A C   1 
ATOM 1533 O O   . TRP A 1 285 ? 125.644 132.556 149.078 1.00 43.93  ? 259 TRP A O   1 
ATOM 1534 C CB  . TRP A 1 285 ? 126.473 134.996 150.932 1.00 43.93  ? 259 TRP A CB  1 
ATOM 1535 C CG  . TRP A 1 285 ? 125.225 135.576 151.520 1.00 43.93  ? 259 TRP A CG  1 
ATOM 1536 C CD1 . TRP A 1 285 ? 124.896 136.896 151.616 1.00 43.93  ? 259 TRP A CD1 1 
ATOM 1537 C CD2 . TRP A 1 285 ? 124.139 134.851 152.099 1.00 43.93  ? 259 TRP A CD2 1 
ATOM 1538 N NE1 . TRP A 1 285 ? 123.672 137.037 152.213 1.00 43.93  ? 259 TRP A NE1 1 
ATOM 1539 C CE2 . TRP A 1 285 ? 123.186 135.794 152.522 1.00 43.93  ? 259 TRP A CE2 1 
ATOM 1540 C CE3 . TRP A 1 285 ? 123.880 133.494 152.302 1.00 43.93  ? 259 TRP A CE3 1 
ATOM 1541 C CZ2 . TRP A 1 285 ? 121.996 135.424 153.130 1.00 43.93  ? 259 TRP A CZ2 1 
ATOM 1542 C CZ3 . TRP A 1 285 ? 122.702 133.131 152.905 1.00 43.93  ? 259 TRP A CZ3 1 
ATOM 1543 C CH2 . TRP A 1 285 ? 121.773 134.090 153.314 1.00 43.93  ? 259 TRP A CH2 1 
ATOM 1544 N N   . LEU A 1 286 ? 124.113 134.195 148.800 1.00 39.57  ? 260 LEU A N   1 
ATOM 1545 C CA  . LEU A 1 286 ? 123.048 133.269 148.432 1.00 39.57  ? 260 LEU A CA  1 
ATOM 1546 C C   . LEU A 1 286 ? 123.329 132.620 147.090 1.00 39.57  ? 260 LEU A C   1 
ATOM 1547 O O   . LEU A 1 286 ? 123.037 131.434 146.895 1.00 39.57  ? 260 LEU A O   1 
ATOM 1548 C CB  . LEU A 1 286 ? 121.710 134.002 148.405 1.00 39.57  ? 260 LEU A CB  1 
ATOM 1549 C CG  . LEU A 1 286 ? 120.895 133.901 149.686 1.00 39.57  ? 260 LEU A CG  1 
ATOM 1550 C CD1 . LEU A 1 286 ? 119.637 134.723 149.574 1.00 39.57  ? 260 LEU A CD1 1 
ATOM 1551 C CD2 . LEU A 1 286 ? 120.565 132.454 149.971 1.00 39.57  ? 260 LEU A CD2 1 
ATOM 1552 N N   . ASN A 1 287 ? 123.911 133.389 146.163 1.00 32.16  ? 261 ASN A N   1 
ATOM 1553 C CA  . ASN A 1 287 ? 124.317 132.875 144.859 1.00 32.16  ? 261 ASN A CA  1 
ATOM 1554 C C   . ASN A 1 287 ? 125.318 131.737 145.001 1.00 32.16  ? 261 ASN A C   1 
ATOM 1555 O O   . ASN A 1 287 ? 125.162 130.668 144.395 1.00 32.16  ? 261 ASN A O   1 
ATOM 1556 C CB  . ASN A 1 287 ? 124.933 134.009 144.041 1.00 32.16  ? 261 ASN A CB  1 
ATOM 1557 C CG  . ASN A 1 287 ? 123.984 135.152 143.798 1.00 32.16  ? 261 ASN A CG  1 
ATOM 1558 O OD1 . ASN A 1 287 ? 122.777 134.978 143.801 1.00 32.16  ? 261 ASN A OD1 1 
ATOM 1559 N ND2 . ASN A 1 287 ? 124.533 136.337 143.573 1.00 32.16  ? 261 ASN A ND2 1 
ATOM 1560 N N   . PHE A 1 288 ? 126.333 131.936 145.844 1.00 32.20  ? 262 PHE A N   1 
ATOM 1561 C CA  . PHE A 1 288 ? 127.368 130.925 146.012 1.00 32.20  ? 262 PHE A CA  1 
ATOM 1562 C C   . PHE A 1 288 ? 126.879 129.742 146.823 1.00 32.20  ? 262 PHE A C   1 
ATOM 1563 O O   . PHE A 1 288 ? 127.322 128.620 146.581 1.00 32.20  ? 262 PHE A O   1 
ATOM 1564 C CB  . PHE A 1 288 ? 128.601 131.540 146.655 1.00 32.20  ? 262 PHE A CB  1 
ATOM 1565 C CG  . PHE A 1 288 ? 129.339 132.454 145.746 1.00 32.20  ? 262 PHE A CG  1 
ATOM 1566 C CD1 . PHE A 1 288 ? 130.013 131.954 144.650 1.00 32.20  ? 262 PHE A CD1 1 
ATOM 1567 C CD2 . PHE A 1 288 ? 129.330 133.814 145.963 1.00 32.20  ? 262 PHE A CD2 1 
ATOM 1568 C CE1 . PHE A 1 288 ? 130.686 132.794 143.800 1.00 32.20  ? 262 PHE A CE1 1 
ATOM 1569 C CE2 . PHE A 1 288 ? 129.998 134.656 145.116 1.00 32.20  ? 262 PHE A CE2 1 
ATOM 1570 C CZ  . PHE A 1 288 ? 130.678 134.147 144.034 1.00 32.20  ? 262 PHE A CZ  1 
ATOM 1571 N N   . LEU A 1 289 ? 125.965 129.961 147.772 1.00 34.13  ? 263 LEU A N   1 
ATOM 1572 C CA  . LEU A 1 289 ? 125.385 128.836 148.499 1.00 34.13  ? 263 LEU A CA  1 
ATOM 1573 C C   . LEU A 1 289 ? 124.527 127.968 147.586 1.00 34.13  ? 263 LEU A C   1 
ATOM 1574 O O   . LEU A 1 289 ? 124.599 126.735 147.651 1.00 34.13  ? 263 LEU A O   1 
ATOM 1575 C CB  . LEU A 1 289 ? 124.569 129.338 149.687 1.00 34.13  ? 263 LEU A CB  1 
ATOM 1576 C CG  . LEU A 1 289 ? 125.328 129.484 151.004 1.00 34.13  ? 263 LEU A CG  1 
ATOM 1577 C CD1 . LEU A 1 289 ? 124.362 129.848 152.108 1.00 34.13  ? 263 LEU A CD1 1 
ATOM 1578 C CD2 . LEU A 1 289 ? 126.076 128.210 151.350 1.00 34.13  ? 263 LEU A CD2 1 
ATOM 1579 N N   . VAL A 1 290 ? 123.730 128.593 146.711 1.00 32.06  ? 264 VAL A N   1 
ATOM 1580 C CA  . VAL A 1 290 ? 122.904 127.836 145.771 1.00 32.06  ? 264 VAL A CA  1 
ATOM 1581 C C   . VAL A 1 290 ? 123.781 127.063 144.791 1.00 32.06  ? 264 VAL A C   1 
ATOM 1582 O O   . VAL A 1 290 ? 123.562 125.868 144.554 1.00 32.06  ? 264 VAL A O   1 
ATOM 1583 C CB  . VAL A 1 290 ? 121.919 128.770 145.044 1.00 32.06  ? 264 VAL A CB  1 
ATOM 1584 C CG1 . VAL A 1 290 ? 121.308 128.079 143.843 1.00 32.06  ? 264 VAL A CG1 1 
ATOM 1585 C CG2 . VAL A 1 290 ? 120.812 129.215 145.986 1.00 32.06  ? 264 VAL A CG2 1 
ATOM 1586 N N   . SER A 1 291 ? 124.823 127.716 144.256 1.00 33.13  ? 265 SER A N   1 
ATOM 1587 C CA  . SER A 1 291 ? 125.740 127.040 143.337 1.00 33.13  ? 265 SER A CA  1 
ATOM 1588 C C   . SER A 1 291 ? 126.514 125.917 144.024 1.00 33.13  ? 265 SER A C   1 
ATOM 1589 O O   . SER A 1 291 ? 126.708 124.843 143.439 1.00 33.13  ? 265 SER A O   1 
ATOM 1590 C CB  . SER A 1 291 ? 126.709 128.049 142.730 1.00 33.13  ? 265 SER A CB  1 
ATOM 1591 O OG  . SER A 1 291 ? 126.018 129.002 141.951 1.00 33.13  ? 265 SER A OG  1 
ATOM 1592 N N   . GLY A 1 292 ? 126.947 126.138 145.267 1.00 32.34  ? 266 GLY A N   1 
ATOM 1593 C CA  . GLY A 1 292 ? 127.704 125.124 145.976 1.00 32.34  ? 266 GLY A CA  1 
ATOM 1594 C C   . GLY A 1 292 ? 126.884 123.900 146.328 1.00 32.34  ? 266 GLY A C   1 
ATOM 1595 O O   . GLY A 1 292 ? 127.321 122.772 146.095 1.00 32.34  ? 266 GLY A O   1 
ATOM 1596 N N   . LEU A 1 293 ? 125.678 124.098 146.869 1.00 30.96  ? 267 LEU A N   1 
ATOM 1597 C CA  . LEU A 1 293 ? 124.827 122.940 147.131 1.00 30.96  ? 267 LEU A CA  1 
ATOM 1598 C C   . LEU A 1 293 ? 124.323 122.287 145.851 1.00 30.96  ? 267 LEU A C   1 
ATOM 1599 O O   . LEU A 1 293 ? 124.111 121.073 145.845 1.00 30.96  ? 267 LEU A O   1 
ATOM 1600 C CB  . LEU A 1 293 ? 123.665 123.285 148.066 1.00 30.96  ? 267 LEU A CB  1 
ATOM 1601 C CG  . LEU A 1 293 ? 123.932 123.390 149.580 1.00 30.96  ? 267 LEU A CG  1 
ATOM 1602 C CD1 . LEU A 1 293 ? 124.729 124.589 150.057 1.00 30.96  ? 267 LEU A CD1 1 
ATOM 1603 C CD2 . LEU A 1 293 ? 122.608 123.315 150.325 1.00 30.96  ? 267 LEU A CD2 1 
ATOM 1604 N N   . PHE A 1 294 ? 124.177 123.035 144.752 1.00 31.42  ? 268 PHE A N   1 
ATOM 1605 C CA  . PHE A 1 294 ? 123.825 122.389 143.490 1.00 31.42  ? 268 PHE A CA  1 
ATOM 1606 C C   . PHE A 1 294 ? 124.964 121.519 142.977 1.00 31.42  ? 268 PHE A C   1 
ATOM 1607 O O   . PHE A 1 294 ? 124.725 120.433 142.435 1.00 31.42  ? 268 PHE A O   1 
ATOM 1608 C CB  . PHE A 1 294 ? 123.438 123.425 142.441 1.00 31.42  ? 268 PHE A CB  1 
ATOM 1609 C CG  . PHE A 1 294 ? 122.721 122.838 141.262 1.00 31.42  ? 268 PHE A CG  1 
ATOM 1610 C CD1 . PHE A 1 294 ? 121.362 122.578 141.324 1.00 31.42  ? 268 PHE A CD1 1 
ATOM 1611 C CD2 . PHE A 1 294 ? 123.406 122.528 140.099 1.00 31.42  ? 268 PHE A CD2 1 
ATOM 1612 C CE1 . PHE A 1 294 ? 120.699 122.031 140.245 1.00 31.42  ? 268 PHE A CE1 1 
ATOM 1613 C CE2 . PHE A 1 294 ? 122.749 121.979 139.018 1.00 31.42  ? 268 PHE A CE2 1 
ATOM 1614 C CZ  . PHE A 1 294 ? 121.396 121.731 139.091 1.00 31.42  ? 268 PHE A CZ  1 
ATOM 1615 N N   . SER A 1 295 ? 126.209 121.966 143.163 1.00 29.60  ? 269 SER A N   1 
ATOM 1616 C CA  . SER A 1 295 ? 127.353 121.147 142.776 1.00 29.60  ? 269 SER A CA  1 
ATOM 1617 C C   . SER A 1 295 ? 127.494 119.923 143.675 1.00 29.60  ? 269 SER A C   1 
ATOM 1618 O O   . SER A 1 295 ? 127.875 118.846 143.205 1.00 29.60  ? 269 SER A O   1 
ATOM 1619 C CB  . SER A 1 295 ? 128.625 121.988 142.791 1.00 29.60  ? 269 SER A CB  1 
ATOM 1620 O OG  . SER A 1 295 ? 128.473 123.143 141.988 1.00 29.60  ? 269 SER A OG  1 
ATOM 1621 N N   . ILE A 1 296 ? 127.168 120.058 144.963 1.00 30.27  ? 270 ILE A N   1 
ATOM 1622 C CA  . ILE A 1 296 ? 127.209 118.902 145.860 1.00 30.27  ? 270 ILE A CA  1 
ATOM 1623 C C   . ILE A 1 296 ? 126.116 117.890 145.509 1.00 30.27  ? 270 ILE A C   1 
ATOM 1624 O O   . ILE A 1 296 ? 126.352 116.677 145.545 1.00 30.27  ? 270 ILE A O   1 
ATOM 1625 C CB  . ILE A 1 296 ? 127.143 119.359 147.332 1.00 30.27  ? 270 ILE A CB  1 
ATOM 1626 C CG1 . ILE A 1 296 ? 128.371 120.198 147.679 1.00 30.27  ? 270 ILE A CG1 1 
ATOM 1627 C CG2 . ILE A 1 296 ? 127.078 118.187 148.292 1.00 30.27  ? 270 ILE A CG2 1 
ATOM 1628 C CD1 . ILE A 1 296 ? 128.272 120.901 149.009 1.00 30.27  ? 270 ILE A CD1 1 
ATOM 1629 N N   . ILE A 1 297 ? 124.919 118.365 145.139 1.00 30.80  ? 271 ILE A N   1 
ATOM 1630 C CA  . ILE A 1 297 ? 123.855 117.464 144.681 1.00 30.80  ? 271 ILE A CA  1 
ATOM 1631 C C   . ILE A 1 297 ? 124.254 116.769 143.382 1.00 30.80  ? 271 ILE A C   1 
ATOM 1632 O O   . ILE A 1 297 ? 124.074 115.554 143.228 1.00 30.80  ? 271 ILE A O   1 
ATOM 1633 C CB  . ILE A 1 297 ? 122.523 118.227 144.533 1.00 30.80  ? 271 ILE A CB  1 
ATOM 1634 C CG1 . ILE A 1 297 ? 121.992 118.665 145.896 1.00 30.80  ? 271 ILE A CG1 1 
ATOM 1635 C CG2 . ILE A 1 297 ? 121.472 117.398 143.814 1.00 30.80  ? 271 ILE A CG2 1 
ATOM 1636 C CD1 . ILE A 1 297 ? 120.892 119.695 145.804 1.00 30.80  ? 271 ILE A CD1 1 
ATOM 1637 N N   . SER A 1 298 ? 124.840 117.518 142.444 1.00 31.99  ? 272 SER A N   1 
ATOM 1638 C CA  . SER A 1 298 ? 125.297 116.922 141.193 1.00 31.99  ? 272 SER A CA  1 
ATOM 1639 C C   . SER A 1 298 ? 126.500 116.000 141.378 1.00 31.99  ? 272 SER A C   1 
ATOM 1640 O O   . SER A 1 298 ? 126.776 115.184 140.495 1.00 31.99  ? 272 SER A O   1 
ATOM 1641 C CB  . SER A 1 298 ? 125.631 118.020 140.187 1.00 31.99  ? 272 SER A CB  1 
ATOM 1642 O OG  . SER A 1 298 ? 126.798 118.717 140.568 1.00 31.99  ? 272 SER A OG  1 
ATOM 1643 N N   . SER A 1 299 ? 127.225 116.120 142.492 1.00 32.45  ? 273 SER A N   1 
ATOM 1644 C CA  . SER A 1 299 ? 128.303 115.184 142.792 1.00 32.45  ? 273 SER A CA  1 
ATOM 1645 C C   . SER A 1 299 ? 127.796 113.824 143.250 1.00 32.45  ? 273 SER A C   1 
ATOM 1646 O O   . SER A 1 299 ? 128.545 112.846 143.165 1.00 32.45  ? 273 SER A O   1 
ATOM 1647 C CB  . SER A 1 299 ? 129.214 115.761 143.871 1.00 32.45  ? 273 SER A CB  1 
ATOM 1648 O OG  . SER A 1 299 ? 128.709 115.467 145.160 1.00 32.45  ? 273 SER A OG  1 
ATOM 1649 N N   . ILE A 1 300 ? 126.559 113.753 143.752 1.00 33.68  ? 274 ILE A N   1 
ATOM 1650 C CA  . ILE A 1 300 ? 126.045 112.502 144.329 1.00 33.68  ? 274 ILE A CA  1 
ATOM 1651 C C   . ILE A 1 300 ? 125.933 111.341 143.339 1.00 33.68  ? 274 ILE A C   1 
ATOM 1652 O O   . ILE A 1 300 ? 126.433 110.248 143.659 1.00 33.68  ? 274 ILE A O   1 
ATOM 1653 C CB  . ILE A 1 300 ? 124.729 112.769 145.078 1.00 33.68  ? 274 ILE A CB  1 
ATOM 1654 C CG1 . ILE A 1 300 ? 124.951 113.789 146.189 1.00 33.68  ? 274 ILE A CG1 1 
ATOM 1655 C CG2 . ILE A 1 300 ? 124.168 111.488 145.668 1.00 33.68  ? 274 ILE A CG2 1 
ATOM 1656 C CD1 . ILE A 1 300 ? 125.943 113.337 147.233 1.00 33.68  ? 274 ILE A CD1 1 
ATOM 1657 N N   . PRO A 1 301 ? 125.308 111.478 142.147 1.00 35.01  ? 275 PRO A N   1 
ATOM 1658 C CA  . PRO A 1 301 ? 125.056 110.265 141.342 1.00 35.01  ? 275 PRO A CA  1 
ATOM 1659 C C   . PRO A 1 301 ? 126.295 109.634 140.736 1.00 35.01  ? 275 PRO A C   1 
ATOM 1660 O O   . PRO A 1 301 ? 126.209 108.506 140.241 1.00 35.01  ? 275 PRO A O   1 
ATOM 1661 C CB  . PRO A 1 301 ? 124.109 110.759 140.240 1.00 35.01  ? 275 PRO A CB  1 
ATOM 1662 C CG  . PRO A 1 301 ? 123.560 112.013 140.736 1.00 35.01  ? 275 PRO A CG  1 
ATOM 1663 C CD  . PRO A 1 301 ? 124.688 112.631 141.457 1.00 35.01  ? 275 PRO A CD  1 
ATOM 1664 N N   . PHE A 1 302 ? 127.440 110.312 140.769 1.00 33.66  ? 276 PHE A N   1 
ATOM 1665 C CA  . PHE A 1 302 ? 128.647 109.767 140.163 1.00 33.66  ? 276 PHE A CA  1 
ATOM 1666 C C   . PHE A 1 302 ? 129.239 108.629 140.979 1.00 33.66  ? 276 PHE A C   1 
ATOM 1667 O O   . PHE A 1 302 ? 129.879 107.734 140.418 1.00 33.66  ? 276 PHE A O   1 
ATOM 1668 C CB  . PHE A 1 302 ? 129.673 110.873 139.989 1.00 33.66  ? 276 PHE A CB  1 
ATOM 1669 C CG  . PHE A 1 302 ? 129.478 111.671 138.751 1.00 33.66  ? 276 PHE A CG  1 
ATOM 1670 C CD1 . PHE A 1 302 ? 129.666 111.097 137.508 1.00 33.66  ? 276 PHE A CD1 1 
ATOM 1671 C CD2 . PHE A 1 302 ? 129.090 112.990 138.826 1.00 33.66  ? 276 PHE A CD2 1 
ATOM 1672 C CE1 . PHE A 1 302 ? 129.481 111.831 136.367 1.00 33.66  ? 276 PHE A CE1 1 
ATOM 1673 C CE2 . PHE A 1 302 ? 128.906 113.722 137.689 1.00 33.66  ? 276 PHE A CE2 1 
ATOM 1674 C CZ  . PHE A 1 302 ? 129.100 113.145 136.457 1.00 33.66  ? 276 PHE A CZ  1 
ATOM 1675 N N   . PHE A 1 303 ? 129.035 108.636 142.294 1.00 35.36  ? 277 PHE A N   1 
ATOM 1676 C CA  . PHE A 1 303 ? 129.590 107.589 143.140 1.00 35.36  ? 277 PHE A CA  1 
ATOM 1677 C C   . PHE A 1 303 ? 128.819 106.280 143.045 1.00 35.36  ? 277 PHE A C   1 
ATOM 1678 O O   . PHE A 1 303 ? 129.277 105.274 143.593 1.00 35.36  ? 277 PHE A O   1 
ATOM 1679 C CB  . PHE A 1 303 ? 129.636 108.070 144.588 1.00 35.36  ? 277 PHE A CB  1 
ATOM 1680 C CG  . PHE A 1 303 ? 130.463 109.303 144.782 1.00 35.36  ? 277 PHE A CG  1 
ATOM 1681 C CD1 . PHE A 1 303 ? 131.837 109.260 144.624 1.00 35.36  ? 277 PHE A CD1 1 
ATOM 1682 C CD2 . PHE A 1 303 ? 129.869 110.508 145.115 1.00 35.36  ? 277 PHE A CD2 1 
ATOM 1683 C CE1 . PHE A 1 303 ? 132.603 110.393 144.799 1.00 35.36  ? 277 PHE A CE1 1 
ATOM 1684 C CE2 . PHE A 1 303 ? 130.632 111.646 145.293 1.00 35.36  ? 277 PHE A CE2 1 
ATOM 1685 C CZ  . PHE A 1 303 ? 131.997 111.587 145.134 1.00 35.36  ? 277 PHE A CZ  1 
ATOM 1686 N N   . PHE A 1 304 ? 127.671 106.268 142.372 1.00 39.42  ? 278 PHE A N   1 
ATOM 1687 C CA  . PHE A 1 304 ? 126.864 105.069 142.215 1.00 39.42  ? 278 PHE A CA  1 
ATOM 1688 C C   . PHE A 1 304 ? 126.980 104.452 140.826 1.00 39.42  ? 278 PHE A C   1 
ATOM 1689 O O   . PHE A 1 304 ? 126.291 103.468 140.542 1.00 39.42  ? 278 PHE A O   1 
ATOM 1690 C CB  . PHE A 1 304 ? 125.397 105.386 142.523 1.00 39.42  ? 278 PHE A CB  1 
ATOM 1691 C CG  . PHE A 1 304 ? 125.057 105.362 143.992 1.00 39.42  ? 278 PHE A CG  1 
ATOM 1692 C CD1 . PHE A 1 304 ? 126.038 105.155 144.952 1.00 39.42  ? 278 PHE A CD1 1 
ATOM 1693 C CD2 . PHE A 1 304 ? 123.751 105.552 144.412 1.00 39.42  ? 278 PHE A CD2 1 
ATOM 1694 C CE1 . PHE A 1 304 ? 125.723 105.137 146.296 1.00 39.42  ? 278 PHE A CE1 1 
ATOM 1695 C CE2 . PHE A 1 304 ? 123.428 105.533 145.756 1.00 39.42  ? 278 PHE A CE2 1 
ATOM 1696 C CZ  . PHE A 1 304 ? 124.417 105.326 146.698 1.00 39.42  ? 278 PHE A CZ  1 
ATOM 1697 N N   . LEU A 1 305 ? 127.845 105.008 139.943 1.00 39.86  ? 279 LEU A N   1 
ATOM 1698 C CA  . LEU A 1 305 ? 128.057 104.593 138.565 1.00 39.86  ? 279 LEU A CA  1 
ATOM 1699 C C   . LEU A 1 305 ? 129.241 103.636 138.460 1.00 39.86  ? 279 LEU A C   1 
ATOM 1700 O O   . LEU A 1 305 ? 130.239 103.796 139.167 1.00 39.86  ? 279 LEU A O   1 
ATOM 1701 C CB  . LEU A 1 305 ? 128.306 105.809 137.681 1.00 39.86  ? 279 LEU A CB  1 
ATOM 1702 C CG  . LEU A 1 305 ? 127.141 106.789 137.578 1.00 39.86  ? 279 LEU A CG  1 
ATOM 1703 C CD1 . LEU A 1 305 ? 127.556 108.053 136.857 1.00 39.86  ? 279 LEU A CD1 1 
ATOM 1704 C CD2 . LEU A 1 305 ? 125.966 106.136 136.882 1.00 39.86  ? 279 LEU A CD2 1 
ATOM 1705 N N   . PRO A 1 306 ? 129.163 102.633 137.587 1.00 42.15  ? 280 PRO A N   1 
ATOM 1706 C CA  . PRO A 1 306 ? 130.273 101.685 137.454 1.00 42.15  ? 280 PRO A CA  1 
ATOM 1707 C C   . PRO A 1 306 ? 131.423 102.274 136.653 1.00 42.15  ? 280 PRO A C   1 
ATOM 1708 O O   . PRO A 1 306 ? 131.290 103.295 135.976 1.00 42.15  ? 280 PRO A O   1 
ATOM 1709 C CB  . PRO A 1 306 ? 129.640 100.502 136.718 1.00 42.15  ? 280 PRO A CB  1 
ATOM 1710 C CG  . PRO A 1 306 ? 128.567 101.120 135.907 1.00 42.15  ? 280 PRO A CG  1 
ATOM 1711 C CD  . PRO A 1 306 ? 128.035 102.279 136.708 1.00 42.15  ? 280 PRO A CD  1 
ATOM 1712 N N   . GLN A 1 307 ? 132.576 101.608 136.749 1.00 42.73  ? 281 GLN A N   1 
ATOM 1713 C CA  . GLN A 1 307 ? 133.746 102.047 135.996 1.00 42.73  ? 281 GLN A CA  1 
ATOM 1714 C C   . GLN A 1 307 ? 133.581 101.768 134.508 1.00 42.73  ? 281 GLN A C   1 
ATOM 1715 O O   . GLN A 1 307 ? 133.973 102.585 133.669 1.00 42.73  ? 281 GLN A O   1 
ATOM 1716 C CB  . GLN A 1 307 ? 135.003 101.367 136.535 1.00 42.73  ? 281 GLN A CB  1 
ATOM 1717 C CG  . GLN A 1 307 ? 136.292 101.866 135.905 1.00 42.73  ? 281 GLN A CG  1 
ATOM 1718 C CD  . GLN A 1 307 ? 137.525 101.428 136.665 1.00 42.73  ? 281 GLN A CD  1 
ATOM 1719 O OE1 . GLN A 1 307 ? 137.440 100.650 137.614 1.00 42.73  ? 281 GLN A OE1 1 
ATOM 1720 N NE2 . GLN A 1 307 ? 138.682 101.931 136.253 1.00 42.73  ? 281 GLN A NE2 1 
ATOM 1721 N N   . THR A 1 308 ? 133.016 100.614 134.160 1.00 44.72  ? 282 THR A N   1 
ATOM 1722 C CA  . THR A 1 308 ? 132.720 100.265 132.779 1.00 44.72  ? 282 THR A CA  1 
ATOM 1723 C C   . THR A 1 308 ? 131.242 99.907  132.690 1.00 44.72  ? 282 THR A C   1 
ATOM 1724 O O   . THR A 1 308 ? 130.734 99.177  133.558 1.00 44.72  ? 282 THR A O   1 
ATOM 1725 C CB  . THR A 1 308 ? 133.581 99.091  132.289 1.00 44.72  ? 282 THR A CB  1 
ATOM 1726 O OG1 . THR A 1 308 ? 133.335 97.942  133.109 1.00 44.72  ? 282 THR A OG1 1 
ATOM 1727 C CG2 . THR A 1 308 ? 135.063 99.436  132.337 1.00 44.72  ? 282 THR A CG2 1 
ATOM 1728 N N   . PRO A 1 309 ? 130.508 100.443 131.709 1.00 45.93  ? 283 PRO A N   1 
ATOM 1729 C CA  . PRO A 1 309 ? 129.108 100.023 131.521 1.00 45.93  ? 283 PRO A CA  1 
ATOM 1730 C C   . PRO A 1 309 ? 128.946 98.545  131.209 1.00 45.93  ? 283 PRO A C   1 
ATOM 1731 O O   . PRO A 1 309 ? 127.962 97.933  131.645 1.00 45.93  ? 283 PRO A O   1 
ATOM 1732 C CB  . PRO A 1 309 ? 128.632 100.884 130.342 1.00 45.93  ? 283 PRO A CB  1 
ATOM 1733 C CG  . PRO A 1 309 ? 129.633 101.972 130.178 1.00 45.93  ? 283 PRO A CG  1 
ATOM 1734 C CD  . PRO A 1 309 ? 130.768 101.768 131.128 1.00 45.93  ? 283 PRO A CD  1 
ATOM 1735 N N   . ASN A 1 310 ? 129.880 97.953  130.474 1.00 50.78  ? 284 ASN A N   1 
ATOM 1736 C CA  . ASN A 1 310 ? 129.776 96.552  130.091 1.00 50.78  ? 284 ASN A CA  1 
ATOM 1737 C C   . ASN A 1 310 ? 130.871 95.716  130.745 1.00 50.78  ? 284 ASN A C   1 
ATOM 1738 O O   . ASN A 1 310 ? 130.608 94.938  131.662 1.00 50.78  ? 284 ASN A O   1 
ATOM 1739 C CB  . ASN A 1 310 ? 129.842 96.412  128.570 1.00 50.78  ? 284 ASN A CB  1 
ATOM 1740 C CG  . ASN A 1 310 ? 128.724 97.156  127.869 1.00 50.78  ? 284 ASN A CG  1 
ATOM 1741 O OD1 . ASN A 1 310 ? 127.674 97.416  128.456 1.00 50.78  ? 284 ASN A OD1 1 
ATOM 1742 N ND2 . ASN A 1 310 ? 128.943 97.505  126.607 1.00 50.78  ? 284 ASN A ND2 1 
ATOM 1743 N N   . GLY A 1 350 ? 153.932 106.425 130.264 1.00 33.92  ? 324 GLY A N   1 
ATOM 1744 C CA  . GLY A 1 350 ? 154.472 107.549 131.007 1.00 33.92  ? 324 GLY A CA  1 
ATOM 1745 C C   . GLY A 1 350 ? 153.841 108.862 130.602 1.00 33.92  ? 324 GLY A C   1 
ATOM 1746 O O   . GLY A 1 350 ? 153.273 108.959 129.523 1.00 33.92  ? 324 GLY A O   1 
ATOM 1747 N N   . PHE A 1 351 ? 153.930 109.867 131.476 1.00 35.02  ? 325 PHE A N   1 
ATOM 1748 C CA  . PHE A 1 351 ? 153.348 111.172 131.177 1.00 35.02  ? 325 PHE A CA  1 
ATOM 1749 C C   . PHE A 1 351 ? 154.133 111.894 130.094 1.00 35.02  ? 325 PHE A C   1 
ATOM 1750 O O   . PHE A 1 351 ? 153.545 112.514 129.200 1.00 35.02  ? 325 PHE A O   1 
ATOM 1751 C CB  . PHE A 1 351 ? 153.291 112.022 132.446 1.00 35.02  ? 325 PHE A CB  1 
ATOM 1752 C CG  . PHE A 1 351 ? 152.815 113.426 132.219 1.00 35.02  ? 325 PHE A CG  1 
ATOM 1753 C CD1 . PHE A 1 351 ? 151.602 113.674 131.600 1.00 35.02  ? 325 PHE A CD1 1 
ATOM 1754 C CD2 . PHE A 1 351 ? 153.576 114.499 132.638 1.00 35.02  ? 325 PHE A CD2 1 
ATOM 1755 C CE1 . PHE A 1 351 ? 151.161 114.970 131.396 1.00 35.02  ? 325 PHE A CE1 1 
ATOM 1756 C CE2 . PHE A 1 351 ? 153.141 115.794 132.435 1.00 35.02  ? 325 PHE A CE2 1 
ATOM 1757 C CZ  . PHE A 1 351 ? 151.930 116.028 131.816 1.00 35.02  ? 325 PHE A CZ  1 
ATOM 1758 N N   . PHE A 1 352 ? 155.462 111.816 130.154 1.00 37.80  ? 326 PHE A N   1 
ATOM 1759 C CA  . PHE A 1 352 ? 156.293 112.564 129.217 1.00 37.80  ? 326 PHE A CA  1 
ATOM 1760 C C   . PHE A 1 352 ? 156.267 111.934 127.831 1.00 37.80  ? 326 PHE A C   1 
ATOM 1761 O O   . PHE A 1 352 ? 156.216 112.650 126.827 1.00 37.80  ? 326 PHE A O   1 
ATOM 1762 C CB  . PHE A 1 352 ? 157.737 112.682 129.725 1.00 37.80  ? 326 PHE A CB  1 
ATOM 1763 C CG  . PHE A 1 352 ? 157.918 113.583 130.939 1.00 37.80  ? 326 PHE A CG  1 
ATOM 1764 C CD1 . PHE A 1 352 ? 157.318 113.312 132.165 1.00 37.80  ? 326 PHE A CD1 1 
ATOM 1765 C CD2 . PHE A 1 352 ? 158.700 114.724 130.831 1.00 37.80  ? 326 PHE A CD2 1 
ATOM 1766 C CE1 . PHE A 1 352 ? 157.496 114.151 133.248 1.00 37.80  ? 326 PHE A CE1 1 
ATOM 1767 C CE2 . PHE A 1 352 ? 158.884 115.567 131.913 1.00 37.80  ? 326 PHE A CE2 1 
ATOM 1768 C CZ  . PHE A 1 352 ? 158.281 115.280 133.122 1.00 37.80  ? 326 PHE A CZ  1 
ATOM 1769 N N   . GLN A 1 353 ? 156.287 110.601 127.759 1.00 38.23  ? 327 GLN A N   1 
ATOM 1770 C CA  . GLN A 1 353 ? 156.231 109.918 126.469 1.00 38.23  ? 327 GLN A CA  1 
ATOM 1771 C C   . GLN A 1 353 ? 154.886 110.128 125.788 1.00 38.23  ? 327 GLN A C   1 
ATOM 1772 O O   . GLN A 1 353 ? 154.823 110.349 124.573 1.00 38.23  ? 327 GLN A O   1 
ATOM 1773 C CB  . GLN A 1 353 ? 156.506 108.427 126.655 1.00 38.23  ? 327 GLN A CB  1 
ATOM 1774 C CG  . GLN A 1 353 ? 157.962 108.091 126.925 1.00 38.23  ? 327 GLN A CG  1 
ATOM 1775 C CD  . GLN A 1 353 ? 158.728 107.783 125.657 1.00 38.23  ? 327 GLN A CD  1 
ATOM 1776 O OE1 . GLN A 1 353 ? 158.507 106.755 125.017 1.00 38.23  ? 327 GLN A OE1 1 
ATOM 1777 N NE2 . GLN A 1 353 ? 159.636 108.676 125.283 1.00 38.23  ? 327 GLN A NE2 1 
ATOM 1778 N N   . SER A 1 354 ? 153.801 110.077 126.563 1.00 36.42  ? 328 SER A N   1 
ATOM 1779 C CA  . SER A 1 354 ? 152.470 110.317 126.017 1.00 36.42  ? 328 SER A CA  1 
ATOM 1780 C C   . SER A 1 354 ? 152.297 111.766 125.583 1.00 36.42  ? 328 SER A C   1 
ATOM 1781 O O   . SER A 1 354 ? 151.695 112.035 124.539 1.00 36.42  ? 328 SER A O   1 
ATOM 1782 C CB  . SER A 1 354 ? 151.417 109.938 127.048 1.00 36.42  ? 328 SER A CB  1 
ATOM 1783 O OG  . SER A 1 354 ? 151.502 108.562 127.369 1.00 36.42  ? 328 SER A OG  1 
ATOM 1784 N N   . PHE A 1 355 ? 152.830 112.709 126.364 1.00 35.53  ? 329 PHE A N   1 
ATOM 1785 C CA  . PHE A 1 355 ? 152.767 114.119 125.988 1.00 35.53  ? 329 PHE A CA  1 
ATOM 1786 C C   . PHE A 1 355 ? 153.607 114.399 124.746 1.00 35.53  ? 329 PHE A C   1 
ATOM 1787 O O   . PHE A 1 355 ? 153.229 115.225 123.906 1.00 35.53  ? 329 PHE A O   1 
ATOM 1788 C CB  . PHE A 1 355 ? 153.210 114.974 127.174 1.00 35.53  ? 329 PHE A CB  1 
ATOM 1789 C CG  . PHE A 1 355 ? 152.538 116.312 127.250 1.00 35.53  ? 329 PHE A CG  1 
ATOM 1790 C CD1 . PHE A 1 355 ? 151.176 116.404 127.455 1.00 35.53  ? 329 PHE A CD1 1 
ATOM 1791 C CD2 . PHE A 1 355 ? 153.281 117.478 127.203 1.00 35.53  ? 329 PHE A CD2 1 
ATOM 1792 C CE1 . PHE A 1 355 ? 150.557 117.635 127.541 1.00 35.53  ? 329 PHE A CE1 1 
ATOM 1793 C CE2 . PHE A 1 355 ? 152.665 118.713 127.302 1.00 35.53  ? 329 PHE A CE2 1 
ATOM 1794 C CZ  . PHE A 1 355 ? 151.303 118.788 127.472 1.00 35.53  ? 329 PHE A CZ  1 
ATOM 1795 N N   . LYS A 1 356 ? 154.736 113.699 124.598 1.00 37.58  ? 330 LYS A N   1 
ATOM 1796 C CA  . LYS A 1 356 ? 155.540 113.814 123.385 1.00 37.58  ? 330 LYS A CA  1 
ATOM 1797 C C   . LYS A 1 356 ? 154.807 113.247 122.177 1.00 37.58  ? 330 LYS A C   1 
ATOM 1798 O O   . LYS A 1 356 ? 154.833 113.843 121.096 1.00 37.58  ? 330 LYS A O   1 
ATOM 1799 C CB  . LYS A 1 356 ? 156.882 113.106 123.581 1.00 37.58  ? 330 LYS A CB  1 
ATOM 1800 C CG  . LYS A 1 356 ? 157.732 112.995 122.325 1.00 37.58  ? 330 LYS A CG  1 
ATOM 1801 C CD  . LYS A 1 356 ? 159.196 112.795 122.660 1.00 37.58  ? 330 LYS A CD  1 
ATOM 1802 C CE  . LYS A 1 356 ? 159.883 114.123 122.930 1.00 37.58  ? 330 LYS A CE  1 
ATOM 1803 N NZ  . LYS A 1 356 ? 159.473 115.164 121.952 1.00 37.58  ? 330 LYS A NZ  1 
ATOM 1804 N N   . SER A 1 357 ? 154.135 112.101 122.344 1.00 36.55  ? 331 SER A N   1 
ATOM 1805 C CA  . SER A 1 357 ? 153.372 111.513 121.244 1.00 36.55  ? 331 SER A CA  1 
ATOM 1806 C C   . SER A 1 357 ? 152.187 112.388 120.863 1.00 36.55  ? 331 SER A C   1 
ATOM 1807 O O   . SER A 1 357 ? 151.760 112.401 119.704 1.00 36.55  ? 331 SER A O   1 
ATOM 1808 C CB  . SER A 1 357 ? 152.891 110.115 121.620 1.00 36.55  ? 331 SER A CB  1 
ATOM 1809 O OG  . SER A 1 357 ? 151.954 110.175 122.677 1.00 36.55  ? 331 SER A OG  1 
ATOM 1810 N N   . ILE A 1 358 ? 151.634 113.111 121.834 1.00 34.78  ? 332 ILE A N   1 
ATOM 1811 C CA  . ILE A 1 358 ? 150.586 114.083 121.548 1.00 34.78  ? 332 ILE A CA  1 
ATOM 1812 C C   . ILE A 1 358 ? 151.142 115.279 120.778 1.00 34.78  ? 332 ILE A C   1 
ATOM 1813 O O   . ILE A 1 358 ? 150.571 115.694 119.763 1.00 34.78  ? 332 ILE A O   1 
ATOM 1814 C CB  . ILE A 1 358 ? 149.896 114.489 122.866 1.00 34.78  ? 332 ILE A CB  1 
ATOM 1815 C CG1 . ILE A 1 358 ? 148.943 113.388 123.327 1.00 34.78  ? 332 ILE A CG1 1 
ATOM 1816 C CG2 . ILE A 1 358 ? 149.180 115.799 122.755 1.00 34.78  ? 332 ILE A CG2 1 
ATOM 1817 C CD1 . ILE A 1 358 ? 147.833 113.113 122.352 1.00 34.78  ? 332 ILE A CD1 1 
ATOM 1818 N N   . LEU A 1 359 ? 152.276 115.832 121.216 1.00 35.09  ? 333 LEU A N   1 
ATOM 1819 C CA  . LEU A 1 359 ? 152.768 117.069 120.613 1.00 35.09  ? 333 LEU A CA  1 
ATOM 1820 C C   . LEU A 1 359 ? 153.564 116.866 119.330 1.00 35.09  ? 333 LEU A C   1 
ATOM 1821 O O   . LEU A 1 359 ? 153.854 117.851 118.645 1.00 35.09  ? 333 LEU A O   1 
ATOM 1822 C CB  . LEU A 1 359 ? 153.635 117.847 121.599 1.00 35.09  ? 333 LEU A CB  1 
ATOM 1823 C CG  . LEU A 1 359 ? 152.907 118.707 122.624 1.00 35.09  ? 333 LEU A CG  1 
ATOM 1824 C CD1 . LEU A 1 359 ? 153.738 118.760 123.870 1.00 35.09  ? 333 LEU A CD1 1 
ATOM 1825 C CD2 . LEU A 1 359 ? 152.671 120.099 122.080 1.00 35.09  ? 333 LEU A CD2 1 
ATOM 1826 N N   . THR A 1 360 ? 153.960 115.640 119.001 1.00 37.03  ? 334 THR A N   1 
ATOM 1827 C CA  . THR A 1 360 ? 154.611 115.414 117.717 1.00 37.03  ? 334 THR A CA  1 
ATOM 1828 C C   . THR A 1 360 ? 153.633 115.037 116.618 1.00 37.03  ? 334 THR A C   1 
ATOM 1829 O O   . THR A 1 360 ? 154.053 114.873 115.469 1.00 37.03  ? 334 THR A O   1 
ATOM 1830 C CB  . THR A 1 360 ? 155.685 114.333 117.834 1.00 37.03  ? 334 THR A CB  1 
ATOM 1831 O OG1 . THR A 1 360 ? 155.107 113.134 118.359 1.00 37.03  ? 334 THR A OG1 1 
ATOM 1832 C CG2 . THR A 1 360 ? 156.835 114.801 118.711 1.00 37.03  ? 334 THR A CG2 1 
ATOM 1833 N N   . ASN A 1 361 ? 152.357 114.897 116.937 1.00 36.21  ? 335 ASN A N   1 
ATOM 1834 C CA  . ASN A 1 361 ? 151.353 114.632 115.920 1.00 36.21  ? 335 ASN A CA  1 
ATOM 1835 C C   . ASN A 1 361 ? 151.065 115.922 115.165 1.00 36.21  ? 335 ASN A C   1 
ATOM 1836 O O   . ASN A 1 361 ? 150.633 116.903 115.782 1.00 36.21  ? 335 ASN A O   1 
ATOM 1837 C CB  . ASN A 1 361 ? 150.088 114.091 116.568 1.00 36.21  ? 335 ASN A CB  1 
ATOM 1838 C CG  . ASN A 1 361 ? 149.278 113.235 115.631 1.00 36.21  ? 335 ASN A CG  1 
ATOM 1839 O OD1 . ASN A 1 361 ? 149.822 112.564 114.755 1.00 36.21  ? 335 ASN A OD1 1 
ATOM 1840 N ND2 . ASN A 1 361 ? 147.968 113.243 115.812 1.00 36.21  ? 335 ASN A ND2 1 
ATOM 1841 N N   . PRO A 1 362 ? 151.295 115.975 113.850 1.00 37.00  ? 336 PRO A N   1 
ATOM 1842 C CA  . PRO A 1 362 ? 151.109 117.250 113.140 1.00 37.00  ? 336 PRO A CA  1 
ATOM 1843 C C   . PRO A 1 362 ? 149.652 117.628 112.964 1.00 37.00  ? 336 PRO A C   1 
ATOM 1844 O O   . PRO A 1 362 ? 149.322 118.823 112.985 1.00 37.00  ? 336 PRO A O   1 
ATOM 1845 C CB  . PRO A 1 362 ? 151.807 117.000 111.798 1.00 37.00  ? 336 PRO A CB  1 
ATOM 1846 C CG  . PRO A 1 362 ? 151.726 115.527 111.603 1.00 37.00  ? 336 PRO A CG  1 
ATOM 1847 C CD  . PRO A 1 362 ? 151.809 114.913 112.969 1.00 37.00  ? 336 PRO A CD  1 
ATOM 1848 N N   . LEU A 1 363 ? 148.775 116.634 112.799 1.00 36.53  ? 337 LEU A N   1 
ATOM 1849 C CA  . LEU A 1 363 ? 147.344 116.895 112.701 1.00 36.53  ? 337 LEU A CA  1 
ATOM 1850 C C   . LEU A 1 363 ? 146.805 117.483 113.995 1.00 36.53  ? 337 LEU A C   1 
ATOM 1851 O O   . LEU A 1 363 ? 146.023 118.440 113.968 1.00 36.53  ? 337 LEU A O   1 
ATOM 1852 C CB  . LEU A 1 363 ? 146.599 115.610 112.347 1.00 36.53  ? 337 LEU A CB  1 
ATOM 1853 C CG  . LEU A 1 363 ? 146.175 115.385 110.893 1.00 36.53  ? 337 LEU A CG  1 
ATOM 1854 C CD1 . LEU A 1 363 ? 147.358 115.450 109.950 1.00 36.53  ? 337 LEU A CD1 1 
ATOM 1855 C CD2 . LEU A 1 363 ? 145.472 114.050 110.760 1.00 36.53  ? 337 LEU A CD2 1 
ATOM 1856 N N   . TYR A 1 364 ? 147.253 116.952 115.139 1.00 33.42  ? 338 TYR A N   1 
ATOM 1857 C CA  . TYR A 1 364 ? 146.820 117.474 116.431 1.00 33.42  ? 338 TYR A CA  1 
ATOM 1858 C C   . TYR A 1 364 ? 147.306 118.898 116.658 1.00 33.42  ? 338 TYR A C   1 
ATOM 1859 O O   . TYR A 1 364 ? 146.531 119.747 117.100 1.00 33.42  ? 338 TYR A O   1 
ATOM 1860 C CB  . TYR A 1 364 ? 147.303 116.574 117.567 1.00 33.42  ? 338 TYR A CB  1 
ATOM 1861 C CG  . TYR A 1 364 ? 146.905 117.085 118.936 1.00 33.42  ? 338 TYR A CG  1 
ATOM 1862 C CD1 . TYR A 1 364 ? 145.628 116.875 119.426 1.00 33.42  ? 338 TYR A CD1 1 
ATOM 1863 C CD2 . TYR A 1 364 ? 147.804 117.783 119.737 1.00 33.42  ? 338 TYR A CD2 1 
ATOM 1864 C CE1 . TYR A 1 364 ? 145.262 117.338 120.660 1.00 33.42  ? 338 TYR A CE1 1 
ATOM 1865 C CE2 . TYR A 1 364 ? 147.429 118.269 120.963 1.00 33.42  ? 338 TYR A CE2 1 
ATOM 1866 C CZ  . TYR A 1 364 ? 146.161 118.030 121.425 1.00 33.42  ? 338 TYR A CZ  1 
ATOM 1867 O OH  . TYR A 1 364 ? 145.780 118.495 122.659 1.00 33.42  ? 338 TYR A OH  1 
ATOM 1868 N N   . VAL A 1 365 ? 148.585 119.171 116.388 1.00 36.48  ? 339 VAL A N   1 
ATOM 1869 C CA  . VAL A 1 365 ? 149.145 120.496 116.649 1.00 36.48  ? 339 VAL A CA  1 
ATOM 1870 C C   . VAL A 1 365 ? 148.516 121.536 115.730 1.00 36.48  ? 339 VAL A C   1 
ATOM 1871 O O   . VAL A 1 365 ? 148.172 122.647 116.167 1.00 36.48  ? 339 VAL A O   1 
ATOM 1872 C CB  . VAL A 1 365 ? 150.678 120.450 116.512 1.00 36.48  ? 339 VAL A CB  1 
ATOM 1873 C CG1 . VAL A 1 365 ? 151.283 121.843 116.547 1.00 36.48  ? 339 VAL A CG1 1 
ATOM 1874 C CG2 . VAL A 1 365 ? 151.264 119.615 117.620 1.00 36.48  ? 339 VAL A CG2 1 
ATOM 1875 N N   . MET A 1 366 ? 148.312 121.178 114.459 1.00 36.24  ? 340 MET A N   1 
ATOM 1876 C CA  . MET A 1 366 ? 147.673 122.102 113.532 1.00 36.24  ? 340 MET A CA  1 
ATOM 1877 C C   . MET A 1 366 ? 146.207 122.317 113.895 1.00 36.24  ? 340 MET A C   1 
ATOM 1878 O O   . MET A 1 366 ? 145.700 123.439 113.787 1.00 36.24  ? 340 MET A O   1 
ATOM 1879 C CB  . MET A 1 366 ? 147.829 121.595 112.100 1.00 36.24  ? 340 MET A CB  1 
ATOM 1880 C CG  . MET A 1 366 ? 147.309 122.550 111.042 1.00 36.24  ? 340 MET A CG  1 
ATOM 1881 S SD  . MET A 1 366 ? 147.536 121.911 109.378 1.00 36.24  ? 340 MET A SD  1 
ATOM 1882 C CE  . MET A 1 366 ? 149.307 122.076 109.215 1.00 36.24  ? 340 MET A CE  1 
ATOM 1883 N N   . PHE A 1 367 ? 145.532 121.274 114.397 1.00 35.20  ? 341 PHE A N   1 
ATOM 1884 C CA  . PHE A 1 367 ? 144.154 121.424 114.859 1.00 35.20  ? 341 PHE A CA  1 
ATOM 1885 C C   . PHE A 1 367 ? 144.061 122.312 116.097 1.00 35.20  ? 341 PHE A C   1 
ATOM 1886 O O   . PHE A 1 367 ? 143.128 123.109 116.219 1.00 35.20  ? 341 PHE A O   1 
ATOM 1887 C CB  . PHE A 1 367 ? 143.548 120.051 115.147 1.00 35.20  ? 341 PHE A CB  1 
ATOM 1888 C CG  . PHE A 1 367 ? 142.060 120.075 115.295 1.00 35.20  ? 341 PHE A CG  1 
ATOM 1889 C CD1 . PHE A 1 367 ? 141.281 120.735 114.366 1.00 35.20  ? 341 PHE A CD1 1 
ATOM 1890 C CD2 . PHE A 1 367 ? 141.441 119.469 116.372 1.00 35.20  ? 341 PHE A CD2 1 
ATOM 1891 C CE1 . PHE A 1 367 ? 139.913 120.786 114.492 1.00 35.20  ? 341 PHE A CE1 1 
ATOM 1892 C CE2 . PHE A 1 367 ? 140.067 119.514 116.507 1.00 35.20  ? 341 PHE A CE2 1 
ATOM 1893 C CZ  . PHE A 1 367 ? 139.305 120.176 115.564 1.00 35.20  ? 341 PHE A CZ  1 
ATOM 1894 N N   . VAL A 1 368 ? 145.015 122.188 117.024 1.00 35.09  ? 342 VAL A N   1 
ATOM 1895 C CA  . VAL A 1 368 ? 144.992 122.997 118.243 1.00 35.09  ? 342 VAL A CA  1 
ATOM 1896 C C   . VAL A 1 368 ? 145.267 124.466 117.930 1.00 35.09  ? 342 VAL A C   1 
ATOM 1897 O O   . VAL A 1 368 ? 144.582 125.354 118.448 1.00 35.09  ? 342 VAL A O   1 
ATOM 1898 C CB  . VAL A 1 368 ? 145.970 122.429 119.288 1.00 35.09  ? 342 VAL A CB  1 
ATOM 1899 C CG1 . VAL A 1 368 ? 146.085 123.347 120.477 1.00 35.09  ? 342 VAL A CG1 1 
ATOM 1900 C CG2 . VAL A 1 368 ? 145.439 121.122 119.802 1.00 35.09  ? 342 VAL A CG2 1 
ATOM 1901 N N   . LEU A 1 369 ? 146.244 124.743 117.056 1.00 35.15  ? 343 LEU A N   1 
ATOM 1902 C CA  . LEU A 1 369 ? 146.498 126.125 116.638 1.00 35.15  ? 343 LEU A CA  1 
ATOM 1903 C C   . LEU A 1 369 ? 145.310 126.704 115.870 1.00 35.15  ? 343 LEU A C   1 
ATOM 1904 O O   . LEU A 1 369 ? 144.929 127.868 116.070 1.00 35.15  ? 343 LEU A O   1 
ATOM 1905 C CB  . LEU A 1 369 ? 147.768 126.186 115.790 1.00 35.15  ? 343 LEU A CB  1 
ATOM 1906 C CG  . LEU A 1 369 ? 148.052 127.494 115.050 1.00 35.15  ? 343 LEU A CG  1 
ATOM 1907 C CD1 . LEU A 1 369 ? 148.515 128.573 116.012 1.00 35.15  ? 343 LEU A CD1 1 
ATOM 1908 C CD2 . LEU A 1 369 ? 149.074 127.288 113.947 1.00 35.15  ? 343 LEU A CD2 1 
ATOM 1909 N N   . LEU A 1 370 ? 144.694 125.880 115.023 1.00 35.98  ? 344 LEU A N   1 
ATOM 1910 C CA  . LEU A 1 370 ? 143.521 126.253 114.242 1.00 35.98  ? 344 LEU A CA  1 
ATOM 1911 C C   . LEU A 1 370 ? 142.331 126.632 115.122 1.00 35.98  ? 344 LEU A C   1 
ATOM 1912 O O   . LEU A 1 370 ? 141.748 127.719 114.976 1.00 35.98  ? 344 LEU A O   1 
ATOM 1913 C CB  . LEU A 1 370 ? 143.205 125.052 113.361 1.00 35.98  ? 344 LEU A CB  1 
ATOM 1914 C CG  . LEU A 1 370 ? 142.081 124.805 112.397 1.00 35.98  ? 344 LEU A CG  1 
ATOM 1915 C CD1 . LEU A 1 370 ? 142.635 123.922 111.326 1.00 35.98  ? 344 LEU A CD1 1 
ATOM 1916 C CD2 . LEU A 1 370 ? 141.060 124.044 113.173 1.00 35.98  ? 344 LEU A CD2 1 
ATOM 1917 N N   . THR A 1 371 ? 141.962 125.747 116.051 1.00 36.48  ? 345 THR A N   1 
ATOM 1918 C CA  . THR A 1 371 ? 140.851 126.037 116.947 1.00 36.48  ? 345 THR A CA  1 
ATOM 1919 C C   . THR A 1 371 ? 141.199 127.128 117.946 1.00 36.48  ? 345 THR A C   1 
ATOM 1920 O O   . THR A 1 371 ? 140.302 127.835 118.404 1.00 36.48  ? 345 THR A O   1 
ATOM 1921 C CB  . THR A 1 371 ? 140.402 124.773 117.679 1.00 36.48  ? 345 THR A CB  1 
ATOM 1922 O OG1 . THR A 1 371 ? 141.479 124.262 118.470 1.00 36.48  ? 345 THR A OG1 1 
ATOM 1923 C CG2 . THR A 1 371 ? 139.923 123.717 116.707 1.00 36.48  ? 345 THR A CG2 1 
ATOM 1924 N N   . LEU A 1 372 ? 142.484 127.297 118.277 1.00 33.10  ? 346 LEU A N   1 
ATOM 1925 C CA  . LEU A 1 372 ? 142.893 128.416 119.116 1.00 33.10  ? 346 LEU A CA  1 
ATOM 1926 C C   . LEU A 1 372 ? 142.637 129.744 118.423 1.00 33.10  ? 346 LEU A C   1 
ATOM 1927 O O   . LEU A 1 372 ? 142.108 130.674 119.039 1.00 33.10  ? 346 LEU A O   1 
ATOM 1928 C CB  . LEU A 1 372 ? 144.369 128.281 119.489 1.00 33.10  ? 346 LEU A CB  1 
ATOM 1929 C CG  . LEU A 1 372 ? 145.014 129.521 120.104 1.00 33.10  ? 346 LEU A CG  1 
ATOM 1930 C CD1 . LEU A 1 372 ? 144.476 129.725 121.496 1.00 33.10  ? 346 LEU A CD1 1 
ATOM 1931 C CD2 . LEU A 1 372 ? 146.520 129.400 120.129 1.00 33.10  ? 346 LEU A CD2 1 
ATOM 1932 N N   . LEU A 1 373 ? 142.962 129.833 117.129 1.00 37.45  ? 347 LEU A N   1 
ATOM 1933 C CA  . LEU A 1 373 ? 142.676 131.049 116.371 1.00 37.45  ? 347 LEU A CA  1 
ATOM 1934 C C   . LEU A 1 373 ? 141.176 131.298 116.251 1.00 37.45  ? 347 LEU A C   1 
ATOM 1935 O O   . LEU A 1 373 ? 140.710 132.435 116.426 1.00 37.45  ? 347 LEU A O   1 
ATOM 1936 C CB  . LEU A 1 373 ? 143.310 130.966 114.985 1.00 37.45  ? 347 LEU A CB  1 
ATOM 1937 C CG  . LEU A 1 373 ? 144.833 131.031 114.911 1.00 37.45  ? 347 LEU A CG  1 
ATOM 1938 C CD1 . LEU A 1 373 ? 145.286 130.923 113.476 1.00 37.45  ? 347 LEU A CD1 1 
ATOM 1939 C CD2 . LEU A 1 373 ? 145.340 132.307 115.536 1.00 37.45  ? 347 LEU A CD2 1 
ATOM 1940 N N   . GLN A 1 374 ? 140.400 130.238 115.996 1.00 37.29  ? 348 GLN A N   1 
ATOM 1941 C CA  . GLN A 1 374 ? 138.953 130.389 115.833 1.00 37.29  ? 348 GLN A CA  1 
ATOM 1942 C C   . GLN A 1 374 ? 138.272 130.822 117.135 1.00 37.29  ? 348 GLN A C   1 
ATOM 1943 O O   . GLN A 1 374 ? 137.487 131.780 117.152 1.00 37.29  ? 348 GLN A O   1 
ATOM 1944 C CB  . GLN A 1 374 ? 138.357 129.076 115.328 1.00 37.29  ? 348 GLN A CB  1 
ATOM 1945 C CG  . GLN A 1 374 ? 136.862 129.101 115.135 1.00 37.29  ? 348 GLN A CG  1 
ATOM 1946 C CD  . GLN A 1 374 ? 136.477 129.500 113.732 1.00 37.29  ? 348 GLN A CD  1 
ATOM 1947 O OE1 . GLN A 1 374 ? 136.507 128.684 112.817 1.00 37.29  ? 348 GLN A OE1 1 
ATOM 1948 N NE2 . GLN A 1 374 ? 136.120 130.764 113.551 1.00 37.29  ? 348 GLN A NE2 1 
ATOM 1949 N N   . VAL A 1 375 ? 138.575 130.135 118.239 1.00 35.77  ? 349 VAL A N   1 
ATOM 1950 C CA  . VAL A 1 375 ? 137.986 130.460 119.532 1.00 35.77  ? 349 VAL A CA  1 
ATOM 1951 C C   . VAL A 1 375 ? 138.513 131.797 120.053 1.00 35.77  ? 349 VAL A C   1 
ATOM 1952 O O   . VAL A 1 375 ? 137.788 132.526 120.744 1.00 35.77  ? 349 VAL A O   1 
ATOM 1953 C CB  . VAL A 1 375 ? 138.230 129.277 120.494 1.00 35.77  ? 349 VAL A CB  1 
ATOM 1954 C CG1 . VAL A 1 375 ? 137.774 129.569 121.904 1.00 35.77  ? 349 VAL A CG1 1 
ATOM 1955 C CG2 . VAL A 1 375 ? 137.472 128.058 119.997 1.00 35.77  ? 349 VAL A CG2 1 
ATOM 1956 N N   . SER A 1 376 ? 139.748 132.171 119.696 1.00 36.82  ? 350 SER A N   1 
ATOM 1957 C CA  . SER A 1 376 ? 140.259 133.496 120.029 1.00 36.82  ? 350 SER A CA  1 
ATOM 1958 C C   . SER A 1 376 ? 139.451 134.586 119.344 1.00 36.82  ? 350 SER A C   1 
ATOM 1959 O O   . SER A 1 376 ? 139.118 135.601 119.967 1.00 36.82  ? 350 SER A O   1 
ATOM 1960 C CB  . SER A 1 376 ? 141.728 133.602 119.633 1.00 36.82  ? 350 SER A CB  1 
ATOM 1961 O OG  . SER A 1 376 ? 142.506 132.611 120.274 1.00 36.82  ? 350 SER A OG  1 
ATOM 1962 N N   . SER A 1 377 ? 139.105 134.376 118.067 1.00 38.60  ? 351 SER A N   1 
ATOM 1963 C CA  . SER A 1 377 ? 138.231 135.316 117.367 1.00 38.60  ? 351 SER A CA  1 
ATOM 1964 C C   . SER A 1 377 ? 136.842 135.368 117.991 1.00 38.60  ? 351 SER A C   1 
ATOM 1965 O O   . SER A 1 377 ? 136.263 136.452 118.123 1.00 38.60  ? 351 SER A O   1 
ATOM 1966 C CB  . SER A 1 377 ? 138.133 134.948 115.890 1.00 38.60  ? 351 SER A CB  1 
ATOM 1967 O OG  . SER A 1 377 ? 137.436 135.952 115.175 1.00 38.60  ? 351 SER A OG  1 
ATOM 1968 N N   . TYR A 1 378 ? 136.310 134.205 118.399 1.00 39.73  ? 352 TYR A N   1 
ATOM 1969 C CA  . TYR A 1 378 ? 134.998 134.138 119.050 1.00 39.73  ? 352 TYR A CA  1 
ATOM 1970 C C   . TYR A 1 378 ? 134.969 134.948 120.340 1.00 39.73  ? 352 TYR A C   1 
ATOM 1971 O O   . TYR A 1 378 ? 134.070 135.769 120.553 1.00 39.73  ? 352 TYR A O   1 
ATOM 1972 C CB  . TYR A 1 378 ? 134.632 132.687 119.368 1.00 39.73  ? 352 TYR A CB  1 
ATOM 1973 C CG  . TYR A 1 378 ? 134.139 131.863 118.207 1.00 39.73  ? 352 TYR A CG  1 
ATOM 1974 C CD1 . TYR A 1 378 ? 133.504 132.452 117.128 1.00 39.73  ? 352 TYR A CD1 1 
ATOM 1975 C CD2 . TYR A 1 378 ? 134.310 130.483 118.197 1.00 39.73  ? 352 TYR A CD2 1 
ATOM 1976 C CE1 . TYR A 1 378 ? 133.054 131.691 116.068 1.00 39.73  ? 352 TYR A CE1 1 
ATOM 1977 C CE2 . TYR A 1 378 ? 133.869 129.717 117.141 1.00 39.73  ? 352 TYR A CE2 1 
ATOM 1978 C CZ  . TYR A 1 378 ? 133.243 130.326 116.078 1.00 39.73  ? 352 TYR A CZ  1 
ATOM 1979 O OH  . TYR A 1 378 ? 132.800 129.570 115.019 1.00 39.73  ? 352 TYR A OH  1 
ATOM 1980 N N   . ILE A 1 379 ? 135.954 134.725 121.212 1.00 38.06  ? 353 ILE A N   1 
ATOM 1981 C CA  . ILE A 1 379 ? 135.969 135.370 122.520 1.00 38.06  ? 353 ILE A CA  1 
ATOM 1982 C C   . ILE A 1 379 ? 136.271 136.857 122.389 1.00 38.06  ? 353 ILE A C   1 
ATOM 1983 O O   . ILE A 1 379 ? 135.635 137.689 123.051 1.00 38.06  ? 353 ILE A O   1 
ATOM 1984 C CB  . ILE A 1 379 ? 136.962 134.649 123.450 1.00 38.06  ? 353 ILE A CB  1 
ATOM 1985 C CG1 . ILE A 1 379 ? 136.502 133.212 123.672 1.00 38.06  ? 353 ILE A CG1 1 
ATOM 1986 C CG2 . ILE A 1 379 ? 137.074 135.347 124.786 1.00 38.06  ? 353 ILE A CG2 1 
ATOM 1987 C CD1 . ILE A 1 379 ? 137.506 132.356 124.366 1.00 38.06  ? 353 ILE A CD1 1 
ATOM 1988 N N   . GLY A 1 380 ? 137.210 137.222 121.510 1.00 40.21  ? 354 GLY A N   1 
ATOM 1989 C CA  . GLY A 1 380 ? 137.518 138.630 121.320 1.00 40.21  ? 354 GLY A CA  1 
ATOM 1990 C C   . GLY A 1 380 ? 136.389 139.403 120.665 1.00 40.21  ? 354 GLY A C   1 
ATOM 1991 O O   . GLY A 1 380 ? 136.227 140.601 120.907 1.00 40.21  ? 354 GLY A O   1 
ATOM 1992 N N   . ALA A 1 381 ? 135.584 138.729 119.839 1.00 40.74  ? 355 ALA A N   1 
ATOM 1993 C CA  . ALA A 1 381 ? 134.383 139.366 119.323 1.00 40.74  ? 355 ALA A CA  1 
ATOM 1994 C C   . ALA A 1 381 ? 133.346 139.531 120.422 1.00 40.74  ? 355 ALA A C   1 
ATOM 1995 O O   . ALA A 1 381 ? 132.952 140.657 120.743 1.00 40.74  ? 355 ALA A O   1 
ATOM 1996 C CB  . ALA A 1 381 ? 133.816 138.555 118.161 1.00 40.74  ? 355 ALA A CB  1 
ATOM 1997 N N   . PHE A 1 382 ? 132.969 138.419 121.072 1.00 42.47  ? 356 PHE A N   1 
ATOM 1998 C CA  . PHE A 1 382 ? 131.849 138.389 122.012 1.00 42.47  ? 356 PHE A CA  1 
ATOM 1999 C C   . PHE A 1 382 ? 132.108 139.240 123.251 1.00 42.47  ? 356 PHE A C   1 
ATOM 2000 O O   . PHE A 1 382 ? 131.154 139.686 123.898 1.00 42.47  ? 356 PHE A O   1 
ATOM 2001 C CB  . PHE A 1 382 ? 131.552 136.924 122.374 1.00 42.47  ? 356 PHE A CB  1 
ATOM 2002 C CG  . PHE A 1 382 ? 130.512 136.730 123.458 1.00 42.47  ? 356 PHE A CG  1 
ATOM 2003 C CD1 . PHE A 1 382 ? 129.170 136.613 123.127 1.00 42.47  ? 356 PHE A CD1 1 
ATOM 2004 C CD2 . PHE A 1 382 ? 130.884 136.568 124.791 1.00 42.47  ? 356 PHE A CD2 1 
ATOM 2005 C CE1 . PHE A 1 382 ? 128.214 136.413 124.106 1.00 42.47  ? 356 PHE A CE1 1 
ATOM 2006 C CE2 . PHE A 1 382 ? 129.931 136.371 125.774 1.00 42.47  ? 356 PHE A CE2 1 
ATOM 2007 C CZ  . PHE A 1 382 ? 128.597 136.288 125.431 1.00 42.47  ? 356 PHE A CZ  1 
ATOM 2008 N N   . THR A 1 383 ? 133.375 139.494 123.587 1.00 41.19  ? 357 THR A N   1 
ATOM 2009 C CA  . THR A 1 383 ? 133.676 140.385 124.698 1.00 41.19  ? 357 THR A CA  1 
ATOM 2010 C C   . THR A 1 383 ? 133.271 141.826 124.395 1.00 41.19  ? 357 THR A C   1 
ATOM 2011 O O   . THR A 1 383 ? 132.804 142.532 125.296 1.00 41.19  ? 357 THR A O   1 
ATOM 2012 C CB  . THR A 1 383 ? 135.170 140.279 125.028 1.00 41.19  ? 357 THR A CB  1 
ATOM 2013 O OG1 . THR A 1 383 ? 135.475 138.926 125.381 1.00 41.19  ? 357 THR A OG1 1 
ATOM 2014 C CG2 . THR A 1 383 ? 135.548 141.156 126.212 1.00 41.19  ? 357 THR A CG2 1 
ATOM 2015 N N   . TYR A 1 384 ? 133.354 142.252 123.131 1.00 43.64  ? 358 TYR A N   1 
ATOM 2016 C CA  . TYR A 1 384 ? 133.125 143.647 122.778 1.00 43.64  ? 358 TYR A CA  1 
ATOM 2017 C C   . TYR A 1 384 ? 132.020 143.847 121.748 1.00 43.64  ? 358 TYR A C   1 
ATOM 2018 O O   . TYR A 1 384 ? 131.970 144.920 121.135 1.00 43.64  ? 358 TYR A O   1 
ATOM 2019 C CB  . TYR A 1 384 ? 134.417 144.281 122.254 1.00 43.64  ? 358 TYR A CB  1 
ATOM 2020 C CG  . TYR A 1 384 ? 135.567 144.215 123.227 1.00 43.64  ? 358 TYR A CG  1 
ATOM 2021 C CD1 . TYR A 1 384 ? 135.687 145.140 124.251 1.00 43.64  ? 358 TYR A CD1 1 
ATOM 2022 C CD2 . TYR A 1 384 ? 136.538 143.230 123.114 1.00 43.64  ? 358 TYR A CD2 1 
ATOM 2023 C CE1 . TYR A 1 384 ? 136.739 145.083 125.142 1.00 43.64  ? 358 TYR A CE1 1 
ATOM 2024 C CE2 . TYR A 1 384 ? 137.592 143.167 123.996 1.00 43.64  ? 358 TYR A CE2 1 
ATOM 2025 C CZ  . TYR A 1 384 ? 137.686 144.094 125.009 1.00 43.64  ? 358 TYR A CZ  1 
ATOM 2026 O OH  . TYR A 1 384 ? 138.734 144.034 125.894 1.00 43.64  ? 358 TYR A OH  1 
ATOM 2027 N N   . VAL A 1 385 ? 131.170 142.835 121.511 1.00 47.86  ? 359 VAL A N   1 
ATOM 2028 C CA  . VAL A 1 385 ? 129.981 143.014 120.667 1.00 47.86  ? 359 VAL A CA  1 
ATOM 2029 C C   . VAL A 1 385 ? 129.108 144.151 121.184 1.00 47.86  ? 359 VAL A C   1 
ATOM 2030 O O   . VAL A 1 385 ? 128.673 145.013 120.413 1.00 47.86  ? 359 VAL A O   1 
ATOM 2031 C CB  . VAL A 1 385 ? 129.172 141.703 120.561 1.00 47.86  ? 359 VAL A CB  1 
ATOM 2032 C CG1 . VAL A 1 385 ? 127.853 141.936 119.848 1.00 47.86  ? 359 VAL A CG1 1 
ATOM 2033 C CG2 . VAL A 1 385 ? 129.912 140.678 119.760 1.00 47.86  ? 359 VAL A CG2 1 
ATOM 2034 N N   . PHE A 1 386 ? 128.870 144.194 122.495 1.00 52.27  ? 360 PHE A N   1 
ATOM 2035 C CA  . PHE A 1 386 ? 127.980 145.207 123.057 1.00 52.27  ? 360 PHE A CA  1 
ATOM 2036 C C   . PHE A 1 386 ? 128.606 146.597 123.025 1.00 52.27  ? 360 PHE A C   1 
ATOM 2037 O O   . PHE A 1 386 ? 127.904 147.587 122.791 1.00 52.27  ? 360 PHE A O   1 
ATOM 2038 C CB  . PHE A 1 386 ? 127.577 144.813 124.475 1.00 52.27  ? 360 PHE A CB  1 
ATOM 2039 C CG  . PHE A 1 386 ? 127.135 143.384 124.597 1.00 52.27  ? 360 PHE A CG  1 
ATOM 2040 C CD1 . PHE A 1 386 ? 125.854 143.016 124.220 1.00 52.27  ? 360 PHE A CD1 1 
ATOM 2041 C CD2 . PHE A 1 386 ? 127.997 142.409 125.076 1.00 52.27  ? 360 PHE A CD2 1 
ATOM 2042 C CE1 . PHE A 1 386 ? 125.437 141.705 124.322 1.00 52.27  ? 360 PHE A CE1 1 
ATOM 2043 C CE2 . PHE A 1 386 ? 127.586 141.095 125.179 1.00 52.27  ? 360 PHE A CE2 1 
ATOM 2044 C CZ  . PHE A 1 386 ? 126.303 140.743 124.803 1.00 52.27  ? 360 PHE A CZ  1 
ATOM 2045 N N   . LYS A 1 387 ? 129.923 146.693 123.231 1.00 53.84  ? 361 LYS A N   1 
ATOM 2046 C CA  . LYS A 1 387 ? 130.600 147.981 123.097 1.00 53.84  ? 361 LYS A CA  1 
ATOM 2047 C C   . LYS A 1 387 ? 130.601 148.458 121.651 1.00 53.84  ? 361 LYS A C   1 
ATOM 2048 O O   . LYS A 1 387 ? 130.434 149.655 121.385 1.00 53.84  ? 361 LYS A O   1 
ATOM 2049 C CB  . LYS A 1 387 ? 132.029 147.885 123.628 1.00 53.84  ? 361 LYS A CB  1 
ATOM 2050 C CG  . LYS A 1 387 ? 132.679 149.227 123.907 1.00 53.84  ? 361 LYS A CG  1 
ATOM 2051 C CD  . LYS A 1 387 ? 132.495 149.637 125.356 1.00 53.84  ? 361 LYS A CD  1 
ATOM 2052 C CE  . LYS A 1 387 ? 132.909 151.082 125.579 1.00 53.84  ? 361 LYS A CE  1 
ATOM 2053 N NZ  . LYS A 1 387 ? 133.040 151.406 127.025 1.00 53.84  ? 361 LYS A NZ  1 
ATOM 2054 N N   . TYR A 1 388 ? 130.769 147.532 120.701 1.00 55.05  ? 362 TYR A N   1 
ATOM 2055 C CA  . TYR A 1 388 ? 130.708 147.886 119.288 1.00 55.05  ? 362 TYR A CA  1 
ATOM 2056 C C   . TYR A 1 388 ? 129.305 148.323 118.878 1.00 55.05  ? 362 TYR A C   1 
ATOM 2057 O O   . TYR A 1 388 ? 129.146 149.244 118.069 1.00 55.05  ? 362 TYR A O   1 
ATOM 2058 C CB  . TYR A 1 388 ? 131.171 146.703 118.442 1.00 55.05  ? 362 TYR A CB  1 
ATOM 2059 C CG  . TYR A 1 388 ? 130.994 146.922 116.965 1.00 55.05  ? 362 TYR A CG  1 
ATOM 2060 C CD1 . TYR A 1 388 ? 131.627 147.977 116.320 1.00 55.05  ? 362 TYR A CD1 1 
ATOM 2061 C CD2 . TYR A 1 388 ? 130.187 146.081 116.215 1.00 55.05  ? 362 TYR A CD2 1 
ATOM 2062 C CE1 . TYR A 1 388 ? 131.460 148.181 114.967 1.00 55.05  ? 362 TYR A CE1 1 
ATOM 2063 C CE2 . TYR A 1 388 ? 130.017 146.279 114.865 1.00 55.05  ? 362 TYR A CE2 1 
ATOM 2064 C CZ  . TYR A 1 388 ? 130.653 147.328 114.248 1.00 55.05  ? 362 TYR A CZ  1 
ATOM 2065 O OH  . TYR A 1 388 ? 130.480 147.519 112.904 1.00 55.05  ? 362 TYR A OH  1 
ATOM 2066 N N   . VAL A 1 389 ? 128.281 147.666 119.425 1.00 58.03  ? 363 VAL A N   1 
ATOM 2067 C CA  . VAL A 1 389 ? 126.894 148.046 119.171 1.00 58.03  ? 363 VAL A CA  1 
ATOM 2068 C C   . VAL A 1 389 ? 126.607 149.425 119.751 1.00 58.03  ? 363 VAL A C   1 
ATOM 2069 O O   . VAL A 1 389 ? 125.954 150.261 119.112 1.00 58.03  ? 363 VAL A O   1 
ATOM 2070 C CB  . VAL A 1 389 ? 125.952 146.964 119.736 1.00 58.03  ? 363 VAL A CB  1 
ATOM 2071 C CG1 . VAL A 1 389 ? 124.546 147.492 119.969 1.00 58.03  ? 363 VAL A CG1 1 
ATOM 2072 C CG2 . VAL A 1 389 ? 125.903 145.780 118.793 1.00 58.03  ? 363 VAL A CG2 1 
ATOM 2073 N N   . GLU A 1 390 ? 127.123 149.692 120.956 1.00 59.22  ? 364 GLU A N   1 
ATOM 2074 C CA  . GLU A 1 390 ? 126.943 150.992 121.596 1.00 59.22  ? 364 GLU A CA  1 
ATOM 2075 C C   . GLU A 1 390 ? 127.624 152.104 120.810 1.00 59.22  ? 364 GLU A C   1 
ATOM 2076 O O   . GLU A 1 390 ? 127.064 153.194 120.647 1.00 59.22  ? 364 GLU A O   1 
ATOM 2077 C CB  . GLU A 1 390 ? 127.479 150.935 123.027 1.00 59.22  ? 364 GLU A CB  1 
ATOM 2078 C CG  . GLU A 1 390 ? 127.536 152.268 123.751 1.00 59.22  ? 364 GLU A CG  1 
ATOM 2079 C CD  . GLU A 1 390 ? 128.155 152.152 125.131 1.00 59.22  ? 364 GLU A CD  1 
ATOM 2080 O OE1 . GLU A 1 390 ? 129.177 151.450 125.270 1.00 59.22  ? 364 GLU A OE1 1 
ATOM 2081 O OE2 . GLU A 1 390 ? 127.619 152.767 126.077 1.00 59.22  ? 364 GLU A OE2 1 
ATOM 2082 N N   . GLN A 1 391 ? 128.818 151.843 120.289 1.00 62.78  ? 365 GLN A N   1 
ATOM 2083 C CA  . GLN A 1 391 ? 129.551 152.911 119.629 1.00 62.78  ? 365 GLN A CA  1 
ATOM 2084 C C   . GLN A 1 391 ? 129.130 153.112 118.178 1.00 62.78  ? 365 GLN A C   1 
ATOM 2085 O O   . GLN A 1 391 ? 129.073 154.256 117.717 1.00 62.78  ? 365 GLN A O   1 
ATOM 2086 C CB  . GLN A 1 391 ? 131.052 152.638 119.732 1.00 62.78  ? 365 GLN A CB  1 
ATOM 2087 C CG  . GLN A 1 391 ? 131.915 153.724 119.152 1.00 62.78  ? 365 GLN A CG  1 
ATOM 2088 C CD  . GLN A 1 391 ? 131.700 155.030 119.884 1.00 62.78  ? 365 GLN A CD  1 
ATOM 2089 O OE1 . GLN A 1 391 ? 131.049 155.934 119.372 1.00 62.78  ? 365 GLN A OE1 1 
ATOM 2090 N NE2 . GLN A 1 391 ? 132.176 155.105 121.115 1.00 62.78  ? 365 GLN A NE2 1 
ATOM 2091 N N   . GLN A 1 392 ? 128.790 152.045 117.459 1.00 61.00  ? 366 GLN A N   1 
ATOM 2092 C CA  . GLN A 1 392 ? 128.484 152.151 116.039 1.00 61.00  ? 366 GLN A CA  1 
ATOM 2093 C C   . GLN A 1 392 ? 127.032 152.523 115.768 1.00 61.00  ? 366 GLN A C   1 
ATOM 2094 O O   . GLN A 1 392 ? 126.766 153.431 114.977 1.00 61.00  ? 366 GLN A O   1 
ATOM 2095 C CB  . GLN A 1 392 ? 128.828 150.838 115.330 1.00 61.00  ? 366 GLN A CB  1 
ATOM 2096 C CG  . GLN A 1 392 ? 128.574 150.875 113.844 1.00 61.00  ? 366 GLN A CG  1 
ATOM 2097 C CD  . GLN A 1 392 ? 129.510 151.819 113.128 1.00 61.00  ? 366 GLN A CD  1 
ATOM 2098 O OE1 . GLN A 1 392 ? 130.699 151.545 112.987 1.00 61.00  ? 366 GLN A OE1 1 
ATOM 2099 N NE2 . GLN A 1 392 ? 128.977 152.946 112.675 1.00 61.00  ? 366 GLN A NE2 1 
ATOM 2100 N N   . TYR A 1 393 ? 126.084 151.845 116.412 1.00 60.26  ? 367 TYR A N   1 
ATOM 2101 C CA  . TYR A 1 393 ? 124.668 152.072 116.157 1.00 60.26  ? 367 TYR A CA  1 
ATOM 2102 C C   . TYR A 1 393 ? 123.964 152.846 117.263 1.00 60.26  ? 367 TYR A C   1 
ATOM 2103 O O   . TYR A 1 393 ? 122.790 153.191 117.101 1.00 60.26  ? 367 TYR A O   1 
ATOM 2104 C CB  . TYR A 1 393 ? 123.954 150.735 115.944 1.00 60.26  ? 367 TYR A CB  1 
ATOM 2105 C CG  . TYR A 1 393 ? 124.580 149.885 114.868 1.00 60.26  ? 367 TYR A CG  1 
ATOM 2106 C CD1 . TYR A 1 393 ? 124.698 150.356 113.568 1.00 60.26  ? 367 TYR A CD1 1 
ATOM 2107 C CD2 . TYR A 1 393 ? 125.060 148.615 115.155 1.00 60.26  ? 367 TYR A CD2 1 
ATOM 2108 C CE1 . TYR A 1 393 ? 125.272 149.585 112.581 1.00 60.26  ? 367 TYR A CE1 1 
ATOM 2109 C CE2 . TYR A 1 393 ? 125.634 147.838 114.176 1.00 60.26  ? 367 TYR A CE2 1 
ATOM 2110 C CZ  . TYR A 1 393 ? 125.738 148.328 112.891 1.00 60.26  ? 367 TYR A CZ  1 
ATOM 2111 O OH  . TYR A 1 393 ? 126.312 147.554 111.912 1.00 60.26  ? 367 TYR A OH  1 
ATOM 2112 N N   . GLY A 1 394 ? 124.638 153.122 118.375 1.00 63.36  ? 368 GLY A N   1 
ATOM 2113 C CA  . GLY A 1 394 ? 124.062 153.940 119.422 1.00 63.36  ? 368 GLY A CA  1 
ATOM 2114 C C   . GLY A 1 394 ? 123.095 153.237 120.344 1.00 63.36  ? 368 GLY A C   1 
ATOM 2115 O O   . GLY A 1 394 ? 122.518 153.888 121.221 1.00 63.36  ? 368 GLY A O   1 
ATOM 2116 N N   . GLN A 1 395 ? 122.899 151.944 120.182 1.00 65.41  ? 369 GLN A N   1 
ATOM 2117 C CA  . GLN A 1 395 ? 121.965 151.203 121.009 1.00 65.41  ? 369 GLN A CA  1 
ATOM 2118 C C   . GLN A 1 395 ? 122.570 150.929 122.387 1.00 65.41  ? 369 GLN A C   1 
ATOM 2119 O O   . GLN A 1 395 ? 123.787 150.786 122.515 1.00 65.41  ? 369 GLN A O   1 
ATOM 2120 C CB  . GLN A 1 395 ? 121.596 149.890 120.325 1.00 65.41  ? 369 GLN A CB  1 
ATOM 2121 C CG  . GLN A 1 395 ? 120.887 150.077 118.995 1.00 65.41  ? 369 GLN A CG  1 
ATOM 2122 C CD  . GLN A 1 395 ? 119.669 150.971 119.097 1.00 65.41  ? 369 GLN A CD  1 
ATOM 2123 O OE1 . GLN A 1 395 ? 118.806 150.769 119.950 1.00 65.41  ? 369 GLN A OE1 1 
ATOM 2124 N NE2 . GLN A 1 395 ? 119.589 151.961 118.218 1.00 65.41  ? 369 GLN A NE2 1 
ATOM 2125 N N   . PRO A 1 396 ? 121.751 150.872 123.438 1.00 69.57  ? 370 PRO A N   1 
ATOM 2126 C CA  . PRO A 1 396 ? 122.291 150.512 124.754 1.00 69.57  ? 370 PRO A CA  1 
ATOM 2127 C C   . PRO A 1 396 ? 122.642 149.034 124.832 1.00 69.57  ? 370 PRO A C   1 
ATOM 2128 O O   . PRO A 1 396 ? 122.085 148.197 124.118 1.00 69.57  ? 370 PRO A O   1 
ATOM 2129 C CB  . PRO A 1 396 ? 121.162 150.870 125.730 1.00 69.57  ? 370 PRO A CB  1 
ATOM 2130 C CG  . PRO A 1 396 ? 119.951 151.097 124.917 1.00 69.57  ? 370 PRO A CG  1 
ATOM 2131 C CD  . PRO A 1 396 ? 120.298 151.119 123.468 1.00 69.57  ? 370 PRO A CD  1 
ATOM 2132 N N   . SER A 1 397 ? 123.585 148.723 125.716 1.00 66.23  ? 371 SER A N   1 
ATOM 2133 C CA  . SER A 1 397 ? 124.073 147.360 125.888 1.00 66.23  ? 371 SER A CA  1 
ATOM 2134 C C   . SER A 1 397 ? 123.045 146.477 126.584 1.00 66.23  ? 371 SER A C   1 
ATOM 2135 O O   . SER A 1 397 ? 123.339 145.338 126.949 1.00 66.23  ? 371 SER A O   1 
ATOM 2136 C CB  . SER A 1 397 ? 125.381 147.360 126.681 1.00 66.23  ? 371 SER A CB  1 
ATOM 2137 O OG  . SER A 1 397 ? 125.779 146.042 127.013 1.00 66.23  ? 371 SER A OG  1 
ATOM 2138 N N   . GLY A 1 405 ? 120.131 137.544 125.437 1.00 72.26  ? 379 GLY A N   1 
ATOM 2139 C CA  . GLY A 1 405 ? 120.024 136.110 125.246 1.00 72.26  ? 379 GLY A CA  1 
ATOM 2140 C C   . GLY A 1 405 ? 118.617 135.579 125.434 1.00 72.26  ? 379 GLY A C   1 
ATOM 2141 O O   . GLY A 1 405 ? 118.430 134.423 125.810 1.00 72.26  ? 379 GLY A O   1 
ATOM 2142 N N   . VAL A 1 406 ? 117.627 136.439 125.186 1.00 75.29  ? 380 VAL A N   1 
ATOM 2143 C CA  . VAL A 1 406 ? 116.229 136.031 125.300 1.00 75.29  ? 380 VAL A CA  1 
ATOM 2144 C C   . VAL A 1 406 ? 115.870 135.049 124.191 1.00 75.29  ? 380 VAL A C   1 
ATOM 2145 O O   . VAL A 1 406 ? 115.266 133.999 124.435 1.00 75.29  ? 380 VAL A O   1 
ATOM 2146 C CB  . VAL A 1 406 ? 115.312 137.269 125.279 1.00 75.29  ? 380 VAL A CB  1 
ATOM 2147 C CG1 . VAL A 1 406 ? 113.848 136.859 125.349 1.00 75.29  ? 380 VAL A CG1 1 
ATOM 2148 C CG2 . VAL A 1 406 ? 115.667 138.213 126.417 1.00 75.29  ? 380 VAL A CG2 1 
ATOM 2149 N N   . ILE A 1 407 ? 116.250 135.373 122.960 1.00 69.58  ? 381 ILE A N   1 
ATOM 2150 C CA  . ILE A 1 407 ? 116.017 134.501 121.818 1.00 69.58  ? 381 ILE A CA  1 
ATOM 2151 C C   . ILE A 1 407 ? 117.292 133.759 121.417 1.00 69.58  ? 381 ILE A C   1 
ATOM 2152 O O   . ILE A 1 407 ? 117.200 132.653 120.860 1.00 69.58  ? 381 ILE A O   1 
ATOM 2153 C CB  . ILE A 1 407 ? 115.448 135.317 120.634 1.00 69.58  ? 381 ILE A CB  1 
ATOM 2154 C CG1 . ILE A 1 407 ? 114.207 136.080 121.092 1.00 69.58  ? 381 ILE A CG1 1 
ATOM 2155 C CG2 . ILE A 1 407 ? 114.977 134.444 119.484 1.00 69.58  ? 381 ILE A CG2 1 
ATOM 2156 C CD1 . ILE A 1 407 ? 113.717 137.108 120.097 1.00 69.58  ? 381 ILE A CD1 1 
ATOM 2157 N N   . THR A 1 408 ? 118.470 134.291 121.765 1.00 64.69  ? 382 THR A N   1 
ATOM 2158 C CA  . THR A 1 408 ? 119.757 133.740 121.348 1.00 64.69  ? 382 THR A CA  1 
ATOM 2159 C C   . THR A 1 408 ? 120.019 132.351 121.928 1.00 64.69  ? 382 THR A C   1 
ATOM 2160 O O   . THR A 1 408 ? 120.555 131.486 121.225 1.00 64.69  ? 382 THR A O   1 
ATOM 2161 C CB  . THR A 1 408 ? 120.861 134.720 121.758 1.00 64.69  ? 382 THR A CB  1 
ATOM 2162 O OG1 . THR A 1 408 ? 120.621 135.985 121.130 1.00 64.69  ? 382 THR A OG1 1 
ATOM 2163 C CG2 . THR A 1 408 ? 122.243 134.226 121.357 1.00 64.69  ? 382 THR A CG2 1 
ATOM 2164 N N   . ILE A 1 409 ? 119.645 132.122 123.193 1.00 58.06  ? 383 ILE A N   1 
ATOM 2165 C CA  . ILE A 1 409 ? 119.944 130.839 123.846 1.00 58.06  ? 383 ILE A CA  1 
ATOM 2166 C C   . ILE A 1 409 ? 119.228 129.647 123.204 1.00 58.06  ? 383 ILE A C   1 
ATOM 2167 O O   . ILE A 1 409 ? 119.884 128.610 122.990 1.00 58.06  ? 383 ILE A O   1 
ATOM 2168 C CB  . ILE A 1 409 ? 119.719 130.960 125.365 1.00 58.06  ? 383 ILE A CB  1 
ATOM 2169 C CG1 . ILE A 1 409 ? 120.864 131.741 126.009 1.00 58.06  ? 383 ILE A CG1 1 
ATOM 2170 C CG2 . ILE A 1 409 ? 119.569 129.598 126.038 1.00 58.06  ? 383 ILE A CG2 1 
ATOM 2171 C CD1 . ILE A 1 409 ? 120.666 132.006 127.483 1.00 58.06  ? 383 ILE A CD1 1 
ATOM 2172 N N   . PRO A 1 410 ? 117.916 129.706 122.862 1.00 57.71  ? 384 PRO A N   1 
ATOM 2173 C CA  . PRO A 1 410 ? 117.354 128.595 122.064 1.00 57.71  ? 384 PRO A CA  1 
ATOM 2174 C C   . PRO A 1 410 ? 117.975 128.424 120.687 1.00 57.71  ? 384 PRO A C   1 
ATOM 2175 O O   . PRO A 1 410 ? 118.073 127.286 120.213 1.00 57.71  ? 384 PRO A O   1 
ATOM 2176 C CB  . PRO A 1 410 ? 115.865 128.948 121.966 1.00 57.71  ? 384 PRO A CB  1 
ATOM 2177 C CG  . PRO A 1 410 ? 115.600 129.739 123.152 1.00 57.71  ? 384 PRO A CG  1 
ATOM 2178 C CD  . PRO A 1 410 ? 116.814 130.576 123.335 1.00 57.71  ? 384 PRO A CD  1 
ATOM 2179 N N   . ILE A 1 411 ? 118.411 129.511 120.042 1.00 53.17  ? 385 ILE A N   1 
ATOM 2180 C CA  . ILE A 1 411 ? 119.079 129.400 118.744 1.00 53.17  ? 385 ILE A CA  1 
ATOM 2181 C C   . ILE A 1 411 ? 120.407 128.660 118.881 1.00 53.17  ? 385 ILE A C   1 
ATOM 2182 O O   . ILE A 1 411 ? 120.717 127.762 118.087 1.00 53.17  ? 385 ILE A O   1 
ATOM 2183 C CB  . ILE A 1 411 ? 119.255 130.796 118.116 1.00 53.17  ? 385 ILE A CB  1 
ATOM 2184 C CG1 . ILE A 1 411 ? 117.909 131.328 117.627 1.00 53.17  ? 385 ILE A CG1 1 
ATOM 2185 C CG2 . ILE A 1 411 ? 120.252 130.777 116.969 1.00 53.17  ? 385 ILE A CG2 1 
ATOM 2186 C CD1 . ILE A 1 411 ? 117.810 132.830 117.626 1.00 53.17  ? 385 ILE A CD1 1 
ATOM 2187 N N   . PHE A 1 412 ? 121.183 128.992 119.916 1.00 49.79  ? 386 PHE A N   1 
ATOM 2188 C CA  . PHE A 1 412 ? 122.460 128.324 120.160 1.00 49.79  ? 386 PHE A CA  1 
ATOM 2189 C C   . PHE A 1 412 ? 122.248 126.858 120.535 1.00 49.79  ? 386 PHE A C   1 
ATOM 2190 O O   . PHE A 1 412 ? 123.006 125.987 120.086 1.00 49.79  ? 386 PHE A O   1 
ATOM 2191 C CB  . PHE A 1 412 ? 123.233 129.107 121.240 1.00 49.79  ? 386 PHE A CB  1 
ATOM 2192 C CG  . PHE A 1 412 ? 124.640 128.593 121.546 1.00 49.79  ? 386 PHE A CG  1 
ATOM 2193 C CD1 . PHE A 1 412 ? 124.870 127.471 122.344 1.00 49.79  ? 386 PHE A CD1 1 
ATOM 2194 C CD2 . PHE A 1 412 ? 125.738 129.343 121.153 1.00 49.79  ? 386 PHE A CD2 1 
ATOM 2195 C CE1 . PHE A 1 412 ? 126.152 127.050 122.632 1.00 49.79  ? 386 PHE A CE1 1 
ATOM 2196 C CE2 . PHE A 1 412 ? 127.026 128.925 121.440 1.00 49.79  ? 386 PHE A CE2 1 
ATOM 2197 C CZ  . PHE A 1 412 ? 127.230 127.781 122.187 1.00 49.79  ? 386 PHE A CZ  1 
ATOM 2198 N N   . ALA A 1 413 ? 121.234 126.569 121.359 1.00 48.40  ? 387 ALA A N   1 
ATOM 2199 C CA  . ALA A 1 413 ? 120.974 125.187 121.759 1.00 48.40  ? 387 ALA A CA  1 
ATOM 2200 C C   . ALA A 1 413 ? 120.516 124.343 120.578 1.00 48.40  ? 387 ALA A C   1 
ATOM 2201 O O   . ALA A 1 413 ? 120.970 123.202 120.406 1.00 48.40  ? 387 ALA A O   1 
ATOM 2202 C CB  . ALA A 1 413 ? 119.934 125.149 122.876 1.00 48.40  ? 387 ALA A CB  1 
ATOM 2203 N N   . SER A 1 414 ? 119.636 124.900 119.739 1.00 47.34  ? 388 SER A N   1 
ATOM 2204 C CA  . SER A 1 414 ? 119.176 124.195 118.551 1.00 47.34  ? 388 SER A CA  1 
ATOM 2205 C C   . SER A 1 414 ? 120.307 124.002 117.552 1.00 47.34  ? 388 SER A C   1 
ATOM 2206 O O   . SER A 1 414 ? 120.390 122.955 116.904 1.00 47.34  ? 388 SER A O   1 
ATOM 2207 C CB  . SER A 1 414 ? 118.016 124.953 117.913 1.00 47.34  ? 388 SER A CB  1 
ATOM 2208 O OG  . SER A 1 414 ? 118.368 126.303 117.684 1.00 47.34  ? 388 SER A OG  1 
ATOM 2209 N N   . GLY A 1 415 ? 121.204 124.985 117.437 1.00 45.06  ? 389 GLY A N   1 
ATOM 2210 C CA  . GLY A 1 415 ? 122.348 124.836 116.554 1.00 45.06  ? 389 GLY A CA  1 
ATOM 2211 C C   . GLY A 1 415 ? 123.322 123.771 117.015 1.00 45.06  ? 389 GLY A C   1 
ATOM 2212 O O   . GLY A 1 415 ? 123.827 122.995 116.202 1.00 45.06  ? 389 GLY A O   1 
ATOM 2213 N N   . MET A 1 416 ? 123.586 123.710 118.327 1.00 41.37  ? 390 MET A N   1 
ATOM 2214 C CA  . MET A 1 416 ? 124.477 122.685 118.874 1.00 41.37  ? 390 MET A CA  1 
ATOM 2215 C C   . MET A 1 416 ? 123.896 121.289 118.684 1.00 41.37  ? 390 MET A C   1 
ATOM 2216 O O   . MET A 1 416 ? 124.588 120.369 118.211 1.00 41.37  ? 390 MET A O   1 
ATOM 2217 C CB  . MET A 1 416 ? 124.730 122.951 120.359 1.00 41.37  ? 390 MET A CB  1 
ATOM 2218 C CG  . MET A 1 416 ? 125.848 123.929 120.657 1.00 41.37  ? 390 MET A CG  1 
ATOM 2219 S SD  . MET A 1 416 ? 127.467 123.143 120.725 1.00 41.37  ? 390 MET A SD  1 
ATOM 2220 C CE  . MET A 1 416 ? 128.525 124.568 120.945 1.00 41.37  ? 390 MET A CE  1 
ATOM 2221 N N   . PHE A 1 417 ? 122.611 121.125 119.026 1.00 39.91  ? 391 PHE A N   1 
ATOM 2222 C CA  . PHE A 1 417 ? 121.957 119.831 118.872 1.00 39.91  ? 391 PHE A CA  1 
ATOM 2223 C C   . PHE A 1 417 ? 121.860 119.432 117.407 1.00 39.91  ? 391 PHE A C   1 
ATOM 2224 O O   . PHE A 1 417 ? 122.046 118.260 117.067 1.00 39.91  ? 391 PHE A O   1 
ATOM 2225 C CB  . PHE A 1 417 ? 120.568 119.857 119.511 1.00 39.91  ? 391 PHE A CB  1 
ATOM 2226 C CG  . PHE A 1 417 ? 119.755 118.632 119.223 1.00 39.91  ? 391 PHE A CG  1 
ATOM 2227 C CD1 . PHE A 1 417 ? 120.063 117.428 119.830 1.00 39.91  ? 391 PHE A CD1 1 
ATOM 2228 C CD2 . PHE A 1 417 ? 118.691 118.679 118.336 1.00 39.91  ? 391 PHE A CD2 1 
ATOM 2229 C CE1 . PHE A 1 417 ? 119.326 116.294 119.561 1.00 39.91  ? 391 PHE A CE1 1 
ATOM 2230 C CE2 . PHE A 1 417 ? 117.953 117.547 118.060 1.00 39.91  ? 391 PHE A CE2 1 
ATOM 2231 C CZ  . PHE A 1 417 ? 118.270 116.354 118.675 1.00 39.91  ? 391 PHE A CZ  1 
ATOM 2232 N N   . LEU A 1 418 ? 121.593 120.395 116.522 1.00 40.78  ? 392 LEU A N   1 
ATOM 2233 C CA  . LEU A 1 418 ? 121.470 120.091 115.106 1.00 40.78  ? 392 LEU A CA  1 
ATOM 2234 C C   . LEU A 1 418 ? 122.814 119.759 114.482 1.00 40.78  ? 392 LEU A C   1 
ATOM 2235 O O   . LEU A 1 418 ? 122.870 118.930 113.575 1.00 40.78  ? 392 LEU A O   1 
ATOM 2236 C CB  . LEU A 1 418 ? 120.819 121.260 114.375 1.00 40.78  ? 392 LEU A CB  1 
ATOM 2237 C CG  . LEU A 1 418 ? 120.122 120.879 113.074 1.00 40.78  ? 392 LEU A CG  1 
ATOM 2238 C CD1 . LEU A 1 418 ? 118.889 120.058 113.381 1.00 40.78  ? 392 LEU A CD1 1 
ATOM 2239 C CD2 . LEU A 1 418 ? 119.770 122.111 112.266 1.00 40.78  ? 392 LEU A CD2 1 
ATOM 2240 N N   . GLY A 1 419 ? 123.900 120.373 114.954 1.00 38.80  ? 393 GLY A N   1 
ATOM 2241 C CA  . GLY A 1 419 ? 125.218 119.990 114.469 1.00 38.80  ? 393 GLY A CA  1 
ATOM 2242 C C   . GLY A 1 419 ? 125.593 118.577 114.871 1.00 38.80  ? 393 GLY A C   1 
ATOM 2243 O O   . GLY A 1 419 ? 126.080 117.791 114.047 1.00 38.80  ? 393 GLY A O   1 
ATOM 2244 N N   . GLY A 1 420 ? 125.335 118.225 116.137 1.00 36.95  ? 394 GLY A N   1 
ATOM 2245 C CA  . GLY A 1 420 ? 125.554 116.849 116.568 1.00 36.95  ? 394 GLY A CA  1 
ATOM 2246 C C   . GLY A 1 420 ? 124.669 115.853 115.840 1.00 36.95  ? 394 GLY A C   1 
ATOM 2247 O O   . GLY A 1 420 ? 125.109 114.755 115.486 1.00 36.95  ? 394 GLY A O   1 
ATOM 2248 N N   . TYR A 1 421 ? 123.423 116.243 115.565 1.00 38.97  ? 395 TYR A N   1 
ATOM 2249 C CA  . TYR A 1 421 ? 122.496 115.365 114.865 1.00 38.97  ? 395 TYR A CA  1 
ATOM 2250 C C   . TYR A 1 421 ? 122.876 115.199 113.399 1.00 38.97  ? 395 TYR A C   1 
ATOM 2251 O O   . TYR A 1 421 ? 122.687 114.120 112.832 1.00 38.97  ? 395 TYR A O   1 
ATOM 2252 C CB  . TYR A 1 421 ? 121.074 115.908 114.998 1.00 38.97  ? 395 TYR A CB  1 
ATOM 2253 C CG  . TYR A 1 421 ? 120.036 115.085 114.277 1.00 38.97  ? 395 TYR A CG  1 
ATOM 2254 C CD1 . TYR A 1 421 ? 119.684 113.823 114.733 1.00 38.97  ? 395 TYR A CD1 1 
ATOM 2255 C CD2 . TYR A 1 421 ? 119.411 115.572 113.138 1.00 38.97  ? 395 TYR A CD2 1 
ATOM 2256 C CE1 . TYR A 1 421 ? 118.738 113.071 114.075 1.00 38.97  ? 395 TYR A CE1 1 
ATOM 2257 C CE2 . TYR A 1 421 ? 118.466 114.825 112.473 1.00 38.97  ? 395 TYR A CE2 1 
ATOM 2258 C CZ  . TYR A 1 421 ? 118.134 113.577 112.945 1.00 38.97  ? 395 TYR A CZ  1 
ATOM 2259 O OH  . TYR A 1 421 ? 117.189 112.835 112.279 1.00 38.97  ? 395 TYR A OH  1 
ATOM 2260 N N   . ILE A 1 422 ? 123.408 116.252 112.771 1.00 38.23  ? 396 ILE A N   1 
ATOM 2261 C CA  . ILE A 1 422 ? 123.898 116.156 111.397 1.00 38.23  ? 396 ILE A CA  1 
ATOM 2262 C C   . ILE A 1 422 ? 125.086 115.207 111.322 1.00 38.23  ? 396 ILE A C   1 
ATOM 2263 O O   . ILE A 1 422 ? 125.153 114.347 110.431 1.00 38.23  ? 396 ILE A O   1 
ATOM 2264 C CB  . ILE A 1 422 ? 124.243 117.560 110.861 1.00 38.23  ? 396 ILE A CB  1 
ATOM 2265 C CG1 . ILE A 1 422 ? 122.976 118.278 110.397 1.00 38.23  ? 396 ILE A CG1 1 
ATOM 2266 C CG2 . ILE A 1 422 ? 125.239 117.501 109.713 1.00 38.23  ? 396 ILE A CG2 1 
ATOM 2267 C CD1 . ILE A 1 422 ? 123.151 119.766 110.205 1.00 38.23  ? 396 ILE A CD1 1 
ATOM 2268 N N   . ILE A 1 423 ? 126.013 115.317 112.285 1.00 37.66  ? 397 ILE A N   1 
ATOM 2269 C CA  . ILE A 1 423 ? 127.171 114.420 112.334 1.00 37.66  ? 397 ILE A CA  1 
ATOM 2270 C C   . ILE A 1 423 ? 126.732 112.973 112.543 1.00 37.66  ? 397 ILE A C   1 
ATOM 2271 O O   . ILE A 1 423 ? 127.249 112.054 111.896 1.00 37.66  ? 397 ILE A O   1 
ATOM 2272 C CB  . ILE A 1 423 ? 128.154 114.879 113.429 1.00 37.66  ? 397 ILE A CB  1 
ATOM 2273 C CG1 . ILE A 1 423 ? 128.769 116.227 113.071 1.00 37.66  ? 397 ILE A CG1 1 
ATOM 2274 C CG2 . ILE A 1 423 ? 129.276 113.875 113.621 1.00 37.66  ? 397 ILE A CG2 1 
ATOM 2275 C CD1 . ILE A 1 423 ? 129.599 116.814 114.179 1.00 37.66  ? 397 ILE A CD1 1 
ATOM 2276 N N   . LYS A 1 424 ? 125.748 112.750 113.418 1.00 38.31  ? 398 LYS A N   1 
ATOM 2277 C CA  . LYS A 1 424 ? 125.310 111.383 113.693 1.00 38.31  ? 398 LYS A CA  1 
ATOM 2278 C C   . LYS A 1 424 ? 124.519 110.792 112.530 1.00 38.31  ? 398 LYS A C   1 
ATOM 2279 O O   . LYS A 1 424 ? 124.747 109.640 112.143 1.00 38.31  ? 398 LYS A O   1 
ATOM 2280 C CB  . LYS A 1 424 ? 124.475 111.338 114.972 1.00 38.31  ? 398 LYS A CB  1 
ATOM 2281 C CG  . LYS A 1 424 ? 123.952 109.949 115.301 1.00 38.31  ? 398 LYS A CG  1 
ATOM 2282 C CD  . LYS A 1 424 ? 122.822 109.986 116.302 1.00 38.31  ? 398 LYS A CD  1 
ATOM 2283 C CE  . LYS A 1 424 ? 122.244 108.604 116.493 1.00 38.31  ? 398 LYS A CE  1 
ATOM 2284 N NZ  . LYS A 1 424 ? 121.757 108.049 115.204 1.00 38.31  ? 398 LYS A NZ  1 
ATOM 2285 N N   . LYS A 1 425 ? 123.586 111.559 111.960 1.00 40.58  ? 399 LYS A N   1 
ATOM 2286 C CA  . LYS A 1 425 ? 122.683 111.007 110.958 1.00 40.58  ? 399 LYS A CA  1 
ATOM 2287 C C   . LYS A 1 425 ? 123.357 110.863 109.602 1.00 40.58  ? 399 LYS A C   1 
ATOM 2288 O O   . LYS A 1 425 ? 123.060 109.923 108.858 1.00 40.58  ? 399 LYS A O   1 
ATOM 2289 C CB  . LYS A 1 425 ? 121.426 111.875 110.844 1.00 40.58  ? 399 LYS A CB  1 
ATOM 2290 C CG  . LYS A 1 425 ? 120.150 111.180 110.301 1.00 40.58  ? 399 LYS A CG  1 
ATOM 2291 C CD  . LYS A 1 425 ? 119.653 109.864 110.973 1.00 40.58  ? 399 LYS A CD  1 
ATOM 2292 C CE  . LYS A 1 425 ? 119.703 109.820 112.511 1.00 40.58  ? 399 LYS A CE  1 
ATOM 2293 N NZ  . LYS A 1 425 ? 119.274 108.499 113.038 1.00 40.58  ? 399 LYS A NZ  1 
ATOM 2294 N N   . PHE A 1 426 ? 124.263 111.778 109.254 1.00 41.26  ? 400 PHE A N   1 
ATOM 2295 C CA  . PHE A 1 426 ? 124.941 111.649 107.972 1.00 41.26  ? 400 PHE A CA  1 
ATOM 2296 C C   . PHE A 1 426 ? 126.128 110.698 108.025 1.00 41.26  ? 400 PHE A C   1 
ATOM 2297 O O   . PHE A 1 426 ? 126.710 110.419 106.971 1.00 41.26  ? 400 PHE A O   1 
ATOM 2298 C CB  . PHE A 1 426 ? 125.382 113.026 107.475 1.00 41.26  ? 400 PHE A CB  1 
ATOM 2299 C CG  . PHE A 1 426 ? 124.271 113.833 106.862 1.00 41.26  ? 400 PHE A CG  1 
ATOM 2300 C CD1 . PHE A 1 426 ? 123.058 113.246 106.541 1.00 41.26  ? 400 PHE A CD1 1 
ATOM 2301 C CD2 . PHE A 1 426 ? 124.444 115.181 106.605 1.00 41.26  ? 400 PHE A CD2 1 
ATOM 2302 C CE1 . PHE A 1 426 ? 122.038 113.990 105.978 1.00 41.26  ? 400 PHE A CE1 1 
ATOM 2303 C CE2 . PHE A 1 426 ? 123.428 115.931 106.041 1.00 41.26  ? 400 PHE A CE2 1 
ATOM 2304 C CZ  . PHE A 1 426 ? 122.226 115.335 105.728 1.00 41.26  ? 400 PHE A CZ  1 
ATOM 2305 N N   . LYS A 1 427 ? 126.476 110.200 109.220 1.00 40.95  ? 401 LYS A N   1 
ATOM 2306 C CA  . LYS A 1 427 ? 127.521 109.192 109.446 1.00 40.95  ? 401 LYS A CA  1 
ATOM 2307 C C   . LYS A 1 427 ? 128.882 109.645 108.926 1.00 40.95  ? 401 LYS A C   1 
ATOM 2308 O O   . LYS A 1 427 ? 129.561 108.917 108.199 1.00 40.95  ? 401 LYS A O   1 
ATOM 2309 C CB  . LYS A 1 427 ? 127.138 107.834 108.850 1.00 40.95  ? 401 LYS A CB  1 
ATOM 2310 C CG  . LYS A 1 427 ? 125.733 107.368 109.192 1.00 40.95  ? 401 LYS A CG  1 
ATOM 2311 C CD  . LYS A 1 427 ? 125.329 106.169 108.348 1.00 40.95  ? 401 LYS A CD  1 
ATOM 2312 C CE  . LYS A 1 427 ? 126.256 104.987 108.587 1.00 40.95  ? 401 LYS A CE  1 
ATOM 2313 N NZ  . LYS A 1 427 ? 126.029 104.362 109.919 1.00 40.95  ? 401 LYS A NZ  1 
ATOM 2314 N N   . LEU A 1 428 ? 129.280 110.857 109.302 1.00 39.85  ? 402 LEU A N   1 
ATOM 2315 C CA  . LEU A 1 428 ? 130.538 111.417 108.832 1.00 39.85  ? 402 LEU A CA  1 
ATOM 2316 C C   . LEU A 1 428 ? 131.725 110.700 109.460 1.00 39.85  ? 402 LEU A C   1 
ATOM 2317 O O   . LEU A 1 428 ? 131.680 110.282 110.619 1.00 39.85  ? 402 LEU A O   1 
ATOM 2318 C CB  . LEU A 1 428 ? 130.609 112.909 109.151 1.00 39.85  ? 402 LEU A CB  1 
ATOM 2319 C CG  . LEU A 1 428 ? 129.384 113.767 108.848 1.00 39.85  ? 402 LEU A CG  1 
ATOM 2320 C CD1 . LEU A 1 428 ? 129.631 115.196 109.275 1.00 39.85  ? 402 LEU A CD1 1 
ATOM 2321 C CD2 . LEU A 1 428 ? 129.055 113.710 107.375 1.00 39.85  ? 402 LEU A CD2 1 
ATOM 2322 N N   . ASN A 1 429 ? 132.789 110.550 108.677 1.00 45.49  ? 403 ASN A N   1 
ATOM 2323 C CA  . ASN A 1 429 ? 134.065 110.068 109.186 1.00 45.49  ? 403 ASN A CA  1 
ATOM 2324 C C   . ASN A 1 429 ? 134.858 111.262 109.710 1.00 45.49  ? 403 ASN A C   1 
ATOM 2325 O O   . ASN A 1 429 ? 134.312 112.349 109.915 1.00 45.49  ? 403 ASN A O   1 
ATOM 2326 C CB  . ASN A 1 429 ? 134.817 109.296 108.106 1.00 45.49  ? 403 ASN A CB  1 
ATOM 2327 C CG  . ASN A 1 429 ? 134.903 110.054 106.800 1.00 45.49  ? 403 ASN A CG  1 
ATOM 2328 O OD1 . ASN A 1 429 ? 134.231 111.065 106.611 1.00 45.49  ? 403 ASN A OD1 1 
ATOM 2329 N ND2 . ASN A 1 429 ? 135.737 109.570 105.889 1.00 45.49  ? 403 ASN A ND2 1 
ATOM 2330 N N   . THR A 1 430 ? 136.156 111.062 109.956 1.00 46.36  ? 404 THR A N   1 
ATOM 2331 C CA  . THR A 1 430 ? 137.009 112.143 110.445 1.00 46.36  ? 404 THR A CA  1 
ATOM 2332 C C   . THR A 1 430 ? 137.132 113.253 109.408 1.00 46.36  ? 404 THR A C   1 
ATOM 2333 O O   . THR A 1 430 ? 137.010 114.445 109.729 1.00 46.36  ? 404 THR A O   1 
ATOM 2334 C CB  . THR A 1 430 ? 138.388 111.587 110.795 1.00 46.36  ? 404 THR A CB  1 
ATOM 2335 O OG1 . THR A 1 430 ? 138.253 110.570 111.794 1.00 46.36  ? 404 THR A OG1 1 
ATOM 2336 C CG2 . THR A 1 430 ? 139.283 112.686 111.336 1.00 46.36  ? 404 THR A CG2 1 
ATOM 2337 N N   . VAL A 1 431 ? 137.327 112.866 108.145 1.00 45.82  ? 405 VAL A N   1 
ATOM 2338 C CA  . VAL A 1 431 ? 137.422 113.828 107.053 1.00 45.82  ? 405 VAL A CA  1 
ATOM 2339 C C   . VAL A 1 431 ? 136.083 114.522 106.840 1.00 45.82  ? 405 VAL A C   1 
ATOM 2340 O O   . VAL A 1 431 ? 136.031 115.729 106.585 1.00 45.82  ? 405 VAL A O   1 
ATOM 2341 C CB  . VAL A 1 431 ? 137.914 113.119 105.777 1.00 45.82  ? 405 VAL A CB  1 
ATOM 2342 C CG1 . VAL A 1 431 ? 138.034 114.090 104.618 1.00 45.82  ? 405 VAL A CG1 1 
ATOM 2343 C CG2 . VAL A 1 431 ? 139.238 112.419 106.036 1.00 45.82  ? 405 VAL A CG2 1 
ATOM 2344 N N   . GLY A 1 432 ? 134.980 113.785 106.993 1.00 43.67  ? 406 GLY A N   1 
ATOM 2345 C CA  . GLY A 1 432 ? 133.663 114.387 106.843 1.00 43.67  ? 406 GLY A CA  1 
ATOM 2346 C C   . GLY A 1 432 ? 133.329 115.389 107.934 1.00 43.67  ? 406 GLY A C   1 
ATOM 2347 O O   . GLY A 1 432 ? 132.753 116.445 107.656 1.00 43.67  ? 406 GLY A O   1 
ATOM 2348 N N   . ILE A 1 433 ? 133.689 115.074 109.184 1.00 41.23  ? 407 ILE A N   1 
ATOM 2349 C CA  . ILE A 1 433 ? 133.493 116.006 110.294 1.00 41.23  ? 407 ILE A CA  1 
ATOM 2350 C C   . ILE A 1 433 ? 134.354 117.247 110.095 1.00 41.23  ? 407 ILE A C   1 
ATOM 2351 O O   . ILE A 1 433 ? 133.917 118.379 110.357 1.00 41.23  ? 407 ILE A O   1 
ATOM 2352 C CB  . ILE A 1 433 ? 133.793 115.303 111.633 1.00 41.23  ? 407 ILE A CB  1 
ATOM 2353 C CG1 . ILE A 1 433 ? 132.697 114.300 111.975 1.00 41.23  ? 407 ILE A CG1 1 
ATOM 2354 C CG2 . ILE A 1 433 ? 133.887 116.281 112.780 1.00 41.23  ? 407 ILE A CG2 1 
ATOM 2355 C CD1 . ILE A 1 433 ? 133.017 113.463 113.193 1.00 41.23  ? 407 ILE A CD1 1 
ATOM 2356 N N   . ALA A 1 434 ? 135.577 117.053 109.586 1.00 40.84  ? 408 ALA A N   1 
ATOM 2357 C CA  . ALA A 1 434 ? 136.459 118.179 109.291 1.00 40.84  ? 408 ALA A CA  1 
ATOM 2358 C C   . ALA A 1 434 ? 135.888 119.084 108.203 1.00 40.84  ? 408 ALA A C   1 
ATOM 2359 O O   . ALA A 1 434 ? 135.912 120.313 108.342 1.00 40.84  ? 408 ALA A O   1 
ATOM 2360 C CB  . ALA A 1 434 ? 137.834 117.659 108.892 1.00 40.84  ? 408 ALA A CB  1 
ATOM 2361 N N   . LYS A 1 435 ? 135.348 118.498 107.128 1.00 41.84  ? 409 LYS A N   1 
ATOM 2362 C CA  . LYS A 1 435 ? 134.723 119.302 106.077 1.00 41.84  ? 409 LYS A CA  1 
ATOM 2363 C C   . LYS A 1 435 ? 133.457 119.992 106.566 1.00 41.84  ? 409 LYS A C   1 
ATOM 2364 O O   . LYS A 1 435 ? 133.166 121.114 106.142 1.00 41.84  ? 409 LYS A O   1 
ATOM 2365 C CB  . LYS A 1 435 ? 134.407 118.456 104.843 1.00 41.84  ? 409 LYS A CB  1 
ATOM 2366 C CG  . LYS A 1 435 ? 135.593 117.800 104.180 1.00 41.84  ? 409 LYS A CG  1 
ATOM 2367 C CD  . LYS A 1 435 ? 135.480 117.861 102.673 1.00 41.84  ? 409 LYS A CD  1 
ATOM 2368 C CE  . LYS A 1 435 ? 136.306 116.770 102.028 1.00 41.84  ? 409 LYS A CE  1 
ATOM 2369 N NZ  . LYS A 1 435 ? 135.591 115.469 102.043 1.00 41.84  ? 409 LYS A NZ  1 
ATOM 2370 N N   . PHE A 1 436 ? 132.692 119.343 107.450 1.00 39.75  ? 410 PHE A N   1 
ATOM 2371 C CA  . PHE A 1 436 ? 131.482 119.963 107.988 1.00 39.75  ? 410 PHE A CA  1 
ATOM 2372 C C   . PHE A 1 436 ? 131.815 121.178 108.852 1.00 39.75  ? 410 PHE A C   1 
ATOM 2373 O O   . PHE A 1 436 ? 131.196 122.242 108.711 1.00 39.75  ? 410 PHE A O   1 
ATOM 2374 C CB  . PHE A 1 436 ? 130.679 118.935 108.785 1.00 39.75  ? 410 PHE A CB  1 
ATOM 2375 C CG  . PHE A 1 436 ? 129.499 119.517 109.512 1.00 39.75  ? 410 PHE A CG  1 
ATOM 2376 C CD1 . PHE A 1 436 ? 128.523 120.223 108.829 1.00 39.75  ? 410 PHE A CD1 1 
ATOM 2377 C CD2 . PHE A 1 436 ? 129.368 119.360 110.880 1.00 39.75  ? 410 PHE A CD2 1 
ATOM 2378 C CE1 . PHE A 1 436 ? 127.446 120.760 109.497 1.00 39.75  ? 410 PHE A CE1 1 
ATOM 2379 C CE2 . PHE A 1 436 ? 128.292 119.896 111.551 1.00 39.75  ? 410 PHE A CE2 1 
ATOM 2380 C CZ  . PHE A 1 436 ? 127.332 120.596 110.859 1.00 39.75  ? 410 PHE A CZ  1 
ATOM 2381 N N   . SER A 1 437 ? 132.810 121.041 109.739 1.00 40.88  ? 411 SER A N   1 
ATOM 2382 C CA  . SER A 1 437 ? 133.236 122.166 110.571 1.00 40.88  ? 411 SER A CA  1 
ATOM 2383 C C   . SER A 1 437 ? 133.848 123.281 109.734 1.00 40.88  ? 411 SER A C   1 
ATOM 2384 O O   . SER A 1 437 ? 133.597 124.471 109.989 1.00 40.88  ? 411 SER A O   1 
ATOM 2385 C CB  . SER A 1 437 ? 134.234 121.694 111.621 1.00 40.88  ? 411 SER A CB  1 
ATOM 2386 O OG  . SER A 1 437 ? 134.683 122.775 112.419 1.00 40.88  ? 411 SER A OG  1 
ATOM 2387 N N   . CYS A 1 438 ? 134.637 122.908 108.718 1.00 42.44  ? 412 CYS A N   1 
ATOM 2388 C CA  . CYS A 1 438 ? 135.206 123.886 107.801 1.00 42.44  ? 412 CYS A CA  1 
ATOM 2389 C C   . CYS A 1 438 ? 134.122 124.636 107.045 1.00 42.44  ? 412 CYS A C   1 
ATOM 2390 O O   . CYS A 1 438 ? 134.209 125.855 106.899 1.00 42.44  ? 412 CYS A O   1 
ATOM 2391 C CB  . CYS A 1 438 ? 136.155 123.198 106.823 1.00 42.44  ? 412 CYS A CB  1 
ATOM 2392 S SG  . CYS A 1 438 ? 136.915 124.311 105.626 1.00 42.44  ? 412 CYS A SG  1 
ATOM 2393 N N   . PHE A 1 439 ? 133.076 123.937 106.593 1.00 42.09  ? 413 PHE A N   1 
ATOM 2394 C CA  . PHE A 1 439 ? 132.016 124.596 105.838 1.00 42.09  ? 413 PHE A CA  1 
ATOM 2395 C C   . PHE A 1 439 ? 131.200 125.524 106.726 1.00 42.09  ? 413 PHE A C   1 
ATOM 2396 O O   . PHE A 1 439 ? 130.801 126.609 106.284 1.00 42.09  ? 413 PHE A O   1 
ATOM 2397 C CB  . PHE A 1 439 ? 131.125 123.551 105.157 1.00 42.09  ? 413 PHE A CB  1 
ATOM 2398 C CG  . PHE A 1 439 ? 130.082 124.137 104.232 1.00 42.09  ? 413 PHE A CG  1 
ATOM 2399 C CD1 . PHE A 1 439 ? 130.389 124.372 102.903 1.00 42.09  ? 413 PHE A CD1 1 
ATOM 2400 C CD2 . PHE A 1 439 ? 128.812 124.478 104.692 1.00 42.09  ? 413 PHE A CD2 1 
ATOM 2401 C CE1 . PHE A 1 439 ? 129.455 124.919 102.046 1.00 42.09  ? 413 PHE A CE1 1 
ATOM 2402 C CE2 . PHE A 1 439 ? 127.875 125.025 103.841 1.00 42.09  ? 413 PHE A CE2 1 
ATOM 2403 C CZ  . PHE A 1 439 ? 128.196 125.244 102.516 1.00 42.09  ? 413 PHE A CZ  1 
ATOM 2404 N N   . THR A 1 440 ? 130.947 125.121 107.977 1.00 41.73  ? 414 THR A N   1 
ATOM 2405 C CA  . THR A 1 440 ? 130.226 126.002 108.894 1.00 41.73  ? 414 THR A CA  1 
ATOM 2406 C C   . THR A 1 440 ? 131.024 127.263 109.197 1.00 41.73  ? 414 THR A C   1 
ATOM 2407 O O   . THR A 1 440 ? 130.457 128.357 109.269 1.00 41.73  ? 414 THR A O   1 
ATOM 2408 C CB  . THR A 1 440 ? 129.874 125.277 110.191 1.00 41.73  ? 414 THR A CB  1 
ATOM 2409 O OG1 . THR A 1 440 ? 131.053 124.697 110.758 1.00 41.73  ? 414 THR A OG1 1 
ATOM 2410 C CG2 . THR A 1 440 ? 128.840 124.204 109.938 1.00 41.73  ? 414 THR A CG2 1 
ATOM 2411 N N   . ALA A 1 441 ? 132.347 127.147 109.333 1.00 41.69  ? 415 ALA A N   1 
ATOM 2412 C CA  . ALA A 1 441 ? 133.121 128.354 109.610 1.00 41.69  ? 415 ALA A CA  1 
ATOM 2413 C C   . ALA A 1 441 ? 133.361 129.210 108.364 1.00 41.69  ? 415 ALA A C   1 
ATOM 2414 O O   . ALA A 1 441 ? 133.483 130.435 108.488 1.00 41.69  ? 415 ALA A O   1 
ATOM 2415 C CB  . ALA A 1 441 ? 134.431 127.993 110.282 1.00 41.69  ? 415 ALA A CB  1 
ATOM 2416 N N   . VAL A 1 442 ? 133.438 128.604 107.170 1.00 43.28  ? 416 VAL A N   1 
ATOM 2417 C CA  . VAL A 1 442 ? 133.441 129.385 105.927 1.00 43.28  ? 416 VAL A CA  1 
ATOM 2418 C C   . VAL A 1 442 ? 132.150 130.177 105.797 1.00 43.28  ? 416 VAL A C   1 
ATOM 2419 O O   . VAL A 1 442 ? 132.165 131.364 105.455 1.00 43.28  ? 416 VAL A O   1 
ATOM 2420 C CB  . VAL A 1 442 ? 133.672 128.484 104.694 1.00 43.28  ? 416 VAL A CB  1 
ATOM 2421 C CG1 . VAL A 1 442 ? 133.546 129.281 103.418 1.00 43.28  ? 416 VAL A CG1 1 
ATOM 2422 C CG2 . VAL A 1 442 ? 135.076 127.954 104.679 1.00 43.28  ? 416 VAL A CG2 1 
ATOM 2423 N N   . MET A 1 443 ? 131.016 129.544 106.105 1.00 47.03  ? 417 MET A N   1 
ATOM 2424 C CA  . MET A 1 443 ? 129.740 130.246 106.030 1.00 47.03  ? 417 MET A CA  1 
ATOM 2425 C C   . MET A 1 443 ? 129.632 131.312 107.117 1.00 47.03  ? 417 MET A C   1 
ATOM 2426 O O   . MET A 1 443 ? 129.049 132.381 106.890 1.00 47.03  ? 417 MET A O   1 
ATOM 2427 C CB  . MET A 1 443 ? 128.601 129.237 106.125 1.00 47.03  ? 417 MET A CB  1 
ATOM 2428 C CG  . MET A 1 443 ? 127.250 129.800 105.786 1.00 47.03  ? 417 MET A CG  1 
ATOM 2429 S SD  . MET A 1 443 ? 127.275 130.812 104.298 1.00 47.03  ? 417 MET A SD  1 
ATOM 2430 C CE  . MET A 1 443 ? 126.422 129.738 103.147 1.00 47.03  ? 417 MET A CE  1 
ATOM 2431 N N   . SER A 1 444 ? 130.230 131.057 108.286 1.00 46.61  ? 418 SER A N   1 
ATOM 2432 C CA  . SER A 1 444 ? 130.255 132.049 109.358 1.00 46.61  ? 418 SER A CA  1 
ATOM 2433 C C   . SER A 1 444 ? 131.077 133.276 108.976 1.00 46.61  ? 418 SER A C   1 
ATOM 2434 O O   . SER A 1 444 ? 130.655 134.409 109.224 1.00 46.61  ? 418 SER A O   1 
ATOM 2435 C CB  . SER A 1 444 ? 130.802 131.421 110.638 1.00 46.61  ? 418 SER A CB  1 
ATOM 2436 O OG  . SER A 1 444 ? 130.962 132.397 111.650 1.00 46.61  ? 418 SER A OG  1 
ATOM 2437 N N   . LEU A 1 445 ? 132.244 133.080 108.354 1.00 47.23  ? 419 LEU A N   1 
ATOM 2438 C CA  . LEU A 1 445 ? 133.031 134.233 107.917 1.00 47.23  ? 419 LEU A CA  1 
ATOM 2439 C C   . LEU A 1 445 ? 132.388 134.913 106.711 1.00 47.23  ? 419 LEU A C   1 
ATOM 2440 O O   . LEU A 1 445 ? 132.487 136.137 106.555 1.00 47.23  ? 419 LEU A O   1 
ATOM 2441 C CB  . LEU A 1 445 ? 134.469 133.815 107.603 1.00 47.23  ? 419 LEU A CB  1 
ATOM 2442 C CG  . LEU A 1 445 ? 135.405 134.913 107.082 1.00 47.23  ? 419 LEU A CG  1 
ATOM 2443 C CD1 . LEU A 1 445 ? 135.460 136.073 108.063 1.00 47.23  ? 419 LEU A CD1 1 
ATOM 2444 C CD2 . LEU A 1 445 ? 136.783 134.398 106.820 1.00 47.23  ? 419 LEU A CD2 1 
ATOM 2445 N N   . SER A 1 446 ? 131.705 134.138 105.863 1.00 48.63  ? 420 SER A N   1 
ATOM 2446 C CA  . SER A 1 446 ? 130.988 134.709 104.729 1.00 48.63  ? 420 SER A CA  1 
ATOM 2447 C C   . SER A 1 446 ? 129.868 135.623 105.193 1.00 48.63  ? 420 SER A C   1 
ATOM 2448 O O   . SER A 1 446 ? 129.603 136.654 104.571 1.00 48.63  ? 420 SER A O   1 
ATOM 2449 C CB  . SER A 1 446 ? 130.433 133.595 103.845 1.00 48.63  ? 420 SER A CB  1 
ATOM 2450 O OG  . SER A 1 446 ? 129.631 134.124 102.804 1.00 48.63  ? 420 SER A OG  1 
ATOM 2451 N N   . PHE A 1 447 ? 129.205 135.264 106.291 1.00 51.65  ? 421 PHE A N   1 
ATOM 2452 C CA  . PHE A 1 447 ? 128.244 136.181 106.889 1.00 51.65  ? 421 PHE A CA  1 
ATOM 2453 C C   . PHE A 1 447 ? 128.916 137.296 107.682 1.00 51.65  ? 421 PHE A C   1 
ATOM 2454 O O   . PHE A 1 447 ? 128.359 138.393 107.767 1.00 51.65  ? 421 PHE A O   1 
ATOM 2455 C CB  . PHE A 1 447 ? 127.264 135.406 107.763 1.00 51.65  ? 421 PHE A CB  1 
ATOM 2456 C CG  . PHE A 1 447 ? 126.303 134.576 106.973 1.00 51.65  ? 421 PHE A CG  1 
ATOM 2457 C CD1 . PHE A 1 447 ? 125.713 135.093 105.830 1.00 51.65  ? 421 PHE A CD1 1 
ATOM 2458 C CD2 . PHE A 1 447 ? 126.002 133.283 107.352 1.00 51.65  ? 421 PHE A CD2 1 
ATOM 2459 C CE1 . PHE A 1 447 ? 124.833 134.337 105.083 1.00 51.65  ? 421 PHE A CE1 1 
ATOM 2460 C CE2 . PHE A 1 447 ? 125.122 132.521 106.610 1.00 51.65  ? 421 PHE A CE2 1 
ATOM 2461 C CZ  . PHE A 1 447 ? 124.538 133.046 105.474 1.00 51.65  ? 421 PHE A CZ  1 
ATOM 2462 N N   . TYR A 1 448 ? 130.100 137.046 108.246 1.00 48.93  ? 422 TYR A N   1 
ATOM 2463 C CA  . TYR A 1 448 ? 130.820 138.065 109.004 1.00 48.93  ? 422 TYR A CA  1 
ATOM 2464 C C   . TYR A 1 448 ? 131.326 139.194 108.120 1.00 48.93  ? 422 TYR A C   1 
ATOM 2465 O O   . TYR A 1 448 ? 131.424 140.337 108.576 1.00 48.93  ? 422 TYR A O   1 
ATOM 2466 C CB  . TYR A 1 448 ? 132.004 137.433 109.738 1.00 48.93  ? 422 TYR A CB  1 
ATOM 2467 C CG  . TYR A 1 448 ? 132.440 138.181 110.976 1.00 48.93  ? 422 TYR A CG  1 
ATOM 2468 C CD1 . TYR A 1 448 ? 133.371 139.207 110.908 1.00 48.93  ? 422 TYR A CD1 1 
ATOM 2469 C CD2 . TYR A 1 448 ? 131.912 137.858 112.214 1.00 48.93  ? 422 TYR A CD2 1 
ATOM 2470 C CE1 . TYR A 1 448 ? 133.758 139.885 112.044 1.00 48.93  ? 422 TYR A CE1 1 
ATOM 2471 C CE2 . TYR A 1 448 ? 132.293 138.524 113.348 1.00 48.93  ? 422 TYR A CE2 1 
ATOM 2472 C CZ  . TYR A 1 448 ? 133.212 139.535 113.261 1.00 48.93  ? 422 TYR A CZ  1 
ATOM 2473 O OH  . TYR A 1 448 ? 133.581 140.197 114.405 1.00 48.93  ? 422 TYR A OH  1 
ATOM 2474 N N   . LEU A 1 449 ? 131.651 138.893 106.864 1.00 51.08  ? 423 LEU A N   1 
ATOM 2475 C CA  . LEU A 1 449 ? 132.250 139.880 105.973 1.00 51.08  ? 423 LEU A CA  1 
ATOM 2476 C C   . LEU A 1 449 ? 131.264 140.941 105.495 1.00 51.08  ? 423 LEU A C   1 
ATOM 2477 O O   . LEU A 1 449 ? 131.696 141.913 104.870 1.00 51.08  ? 423 LEU A O   1 
ATOM 2478 C CB  . LEU A 1 449 ? 132.889 139.174 104.775 1.00 51.08  ? 423 LEU A CB  1 
ATOM 2479 C CG  . LEU A 1 449 ? 134.265 138.547 105.030 1.00 51.08  ? 423 LEU A CG  1 
ATOM 2480 C CD1 . LEU A 1 449 ? 134.682 137.644 103.883 1.00 51.08  ? 423 LEU A CD1 1 
ATOM 2481 C CD2 . LEU A 1 449 ? 135.312 139.617 105.265 1.00 51.08  ? 423 LEU A CD2 1 
ATOM 2482 N N   . LEU A 1 450 ? 129.963 140.790 105.770 1.00 52.41  ? 424 LEU A N   1 
ATOM 2483 C CA  . LEU A 1 450 ? 128.987 141.836 105.472 1.00 52.41  ? 424 LEU A CA  1 
ATOM 2484 C C   . LEU A 1 450 ? 129.052 143.014 106.435 1.00 52.41  ? 424 LEU A C   1 
ATOM 2485 O O   . LEU A 1 450 ? 128.374 144.019 106.195 1.00 52.41  ? 424 LEU A O   1 
ATOM 2486 C CB  . LEU A 1 450 ? 127.554 141.292 105.486 1.00 52.41  ? 424 LEU A CB  1 
ATOM 2487 C CG  . LEU A 1 450 ? 126.952 140.524 104.307 1.00 52.41  ? 424 LEU A CG  1 
ATOM 2488 C CD1 . LEU A 1 450 ? 127.519 139.136 104.154 1.00 52.41  ? 424 LEU A CD1 1 
ATOM 2489 C CD2 . LEU A 1 450 ? 125.440 140.472 104.452 1.00 52.41  ? 424 LEU A CD2 1 
ATOM 2490 N N   . TYR A 1 451 ? 129.839 142.919 107.507 1.00 51.85  ? 425 TYR A N   1 
ATOM 2491 C CA  . TYR A 1 451 ? 129.876 143.966 108.520 1.00 51.85  ? 425 TYR A CA  1 
ATOM 2492 C C   . TYR A 1 451 ? 130.595 145.222 108.054 1.00 51.85  ? 425 TYR A C   1 
ATOM 2493 O O   . TYR A 1 451 ? 130.463 146.268 108.696 1.00 51.85  ? 425 TYR A O   1 
ATOM 2494 C CB  . TYR A 1 451 ? 130.533 143.428 109.787 1.00 51.85  ? 425 TYR A CB  1 
ATOM 2495 C CG  . TYR A 1 451 ? 129.650 142.502 110.575 1.00 51.85  ? 425 TYR A CG  1 
ATOM 2496 C CD1 . TYR A 1 451 ? 128.286 142.451 110.332 1.00 51.85  ? 425 TYR A CD1 1 
ATOM 2497 C CD2 . TYR A 1 451 ? 130.177 141.661 111.540 1.00 51.85  ? 425 TYR A CD2 1 
ATOM 2498 C CE1 . TYR A 1 451 ? 127.476 141.612 111.035 1.00 51.85  ? 425 TYR A CE1 1 
ATOM 2499 C CE2 . TYR A 1 451 ? 129.366 140.805 112.250 1.00 51.85  ? 425 TYR A CE2 1 
ATOM 2500 C CZ  . TYR A 1 451 ? 128.015 140.788 111.989 1.00 51.85  ? 425 TYR A CZ  1 
ATOM 2501 O OH  . TYR A 1 451 ? 127.191 139.944 112.687 1.00 51.85  ? 425 TYR A OH  1 
ATOM 2502 N N   . PHE A 1 452 ? 131.351 145.148 106.962 1.00 51.62  ? 426 PHE A N   1 
ATOM 2503 C CA  . PHE A 1 452 ? 132.021 146.322 106.429 1.00 51.62  ? 426 PHE A CA  1 
ATOM 2504 C C   . PHE A 1 452 ? 131.119 147.168 105.543 1.00 51.62  ? 426 PHE A C   1 
ATOM 2505 O O   . PHE A 1 452 ? 131.546 148.239 105.101 1.00 51.62  ? 426 PHE A O   1 
ATOM 2506 C CB  . PHE A 1 452 ? 133.262 145.904 105.638 1.00 51.62  ? 426 PHE A CB  1 
ATOM 2507 C CG  . PHE A 1 452 ? 134.361 145.340 106.490 1.00 51.62  ? 426 PHE A CG  1 
ATOM 2508 C CD1 . PHE A 1 452 ? 135.095 146.162 107.328 1.00 51.62  ? 426 PHE A CD1 1 
ATOM 2509 C CD2 . PHE A 1 452 ? 134.664 143.989 106.445 1.00 51.62  ? 426 PHE A CD2 1 
ATOM 2510 C CE1 . PHE A 1 452 ? 136.105 145.646 108.110 1.00 51.62  ? 426 PHE A CE1 1 
ATOM 2511 C CE2 . PHE A 1 452 ? 135.674 143.467 107.224 1.00 51.62  ? 426 PHE A CE2 1 
ATOM 2512 C CZ  . PHE A 1 452 ? 136.396 144.296 108.056 1.00 51.62  ? 426 PHE A CZ  1 
ATOM 2513 N N   . PHE A 1 453 ? 129.895 146.719 105.270 1.00 55.45  ? 427 PHE A N   1 
ATOM 2514 C CA  . PHE A 1 453 ? 129.000 147.414 104.355 1.00 55.45  ? 427 PHE A CA  1 
ATOM 2515 C C   . PHE A 1 453 ? 127.794 148.036 105.043 1.00 55.45  ? 427 PHE A C   1 
ATOM 2516 O O   . PHE A 1 453 ? 127.035 148.761 104.392 1.00 55.45  ? 427 PHE A O   1 
ATOM 2517 C CB  . PHE A 1 453 ? 128.525 146.455 103.257 1.00 55.45  ? 427 PHE A CB  1 
ATOM 2518 C CG  . PHE A 1 453 ? 129.639 145.722 102.575 1.00 55.45  ? 427 PHE A CG  1 
ATOM 2519 C CD1 . PHE A 1 453 ? 130.424 146.357 101.629 1.00 55.45  ? 427 PHE A CD1 1 
ATOM 2520 C CD2 . PHE A 1 453 ? 129.902 144.398 102.881 1.00 55.45  ? 427 PHE A CD2 1 
ATOM 2521 C CE1 . PHE A 1 453 ? 131.455 145.685 101.000 1.00 55.45  ? 427 PHE A CE1 1 
ATOM 2522 C CE2 . PHE A 1 453 ? 130.929 143.720 102.254 1.00 55.45  ? 427 PHE A CE2 1 
ATOM 2523 C CZ  . PHE A 1 453 ? 131.707 144.365 101.314 1.00 55.45  ? 427 PHE A CZ  1 
ATOM 2524 N N   . ILE A 1 454 ? 127.595 147.779 106.334 1.00 57.65  ? 428 ILE A N   1 
ATOM 2525 C CA  . ILE A 1 454 ? 126.444 148.304 107.058 1.00 57.65  ? 428 ILE A CA  1 
ATOM 2526 C C   . ILE A 1 454 ? 126.913 149.300 108.112 1.00 57.65  ? 428 ILE A C   1 
ATOM 2527 O O   . ILE A 1 454 ? 126.225 149.551 109.108 1.00 57.65  ? 428 ILE A O   1 
ATOM 2528 C CB  . ILE A 1 454 ? 125.612 147.158 107.666 1.00 57.65  ? 428 ILE A CB  1 
ATOM 2529 C CG1 . ILE A 1 454 ? 126.426 146.351 108.677 1.00 57.65  ? 428 ILE A CG1 1 
ATOM 2530 C CG2 . ILE A 1 454 ? 125.094 146.244 106.578 1.00 57.65  ? 428 ILE A CG2 1 
ATOM 2531 C CD1 . ILE A 1 454 ? 125.592 145.372 109.461 1.00 57.65  ? 428 ILE A CD1 1 
ATOM 2532 N N   . LEU A 1 455 ? 128.070 149.907 107.873 1.00 61.76  ? 429 LEU A N   1 
ATOM 2533 C CA  . LEU A 1 455 ? 128.651 150.857 108.810 1.00 61.76  ? 429 LEU A CA  1 
ATOM 2534 C C   . LEU A 1 455 ? 127.923 152.192 108.713 1.00 61.76  ? 429 LEU A C   1 
ATOM 2535 O O   . LEU A 1 455 ? 127.945 152.841 107.661 1.00 61.76  ? 429 LEU A O   1 
ATOM 2536 C CB  . LEU A 1 455 ? 130.136 151.041 108.512 1.00 61.76  ? 429 LEU A CB  1 
ATOM 2537 C CG  . LEU A 1 455 ? 131.073 149.900 108.896 1.00 61.76  ? 429 LEU A CG  1 
ATOM 2538 C CD1 . LEU A 1 455 ? 132.518 150.302 108.671 1.00 61.76  ? 429 LEU A CD1 1 
ATOM 2539 C CD2 . LEU A 1 455 ? 130.850 149.512 110.331 1.00 61.76  ? 429 LEU A CD2 1 
ATOM 2540 N N   . CYS A 1 456 ? 127.286 152.607 109.805 1.00 70.98  ? 430 CYS A N   1 
ATOM 2541 C CA  . CYS A 1 456 ? 126.671 153.924 109.849 1.00 70.98  ? 430 CYS A CA  1 
ATOM 2542 C C   . CYS A 1 456 ? 127.754 154.994 109.989 1.00 70.98  ? 430 CYS A C   1 
ATOM 2543 O O   . CYS A 1 456 ? 128.901 154.709 110.344 1.00 70.98  ? 430 CYS A O   1 
ATOM 2544 C CB  . CYS A 1 456 ? 125.662 154.007 111.001 1.00 70.98  ? 430 CYS A CB  1 
ATOM 2545 S SG  . CYS A 1 456 ? 124.747 155.576 111.147 1.00 70.98  ? 430 CYS A SG  1 
ATOM 2546 N N   . GLU A 1 457 ? 127.381 156.236 109.689 1.00 72.61  ? 431 GLU A N   1 
ATOM 2547 C CA  . GLU A 1 457 ? 128.342 157.329 109.658 1.00 72.61  ? 431 GLU A CA  1 
ATOM 2548 C C   . GLU A 1 457 ? 128.796 157.713 111.065 1.00 72.61  ? 431 GLU A C   1 
ATOM 2549 O O   . GLU A 1 457 ? 128.179 157.349 112.070 1.00 72.61  ? 431 GLU A O   1 
ATOM 2550 C CB  . GLU A 1 457 ? 127.747 158.544 108.946 1.00 72.61  ? 431 GLU A CB  1 
ATOM 2551 C CG  . GLU A 1 457 ? 128.010 158.572 107.449 1.00 72.61  ? 431 GLU A CG  1 
ATOM 2552 C CD  . GLU A 1 457 ? 127.098 157.644 106.667 1.00 72.61  ? 431 GLU A CD  1 
ATOM 2553 O OE1 . GLU A 1 457 ? 126.080 157.185 107.228 1.00 72.61  ? 431 GLU A OE1 1 
ATOM 2554 O OE2 . GLU A 1 457 ? 127.401 157.372 105.487 1.00 72.61  ? 431 GLU A OE2 1 
ATOM 2555 N N   . ASN A 1 458 ? 129.906 158.448 111.120 1.00 72.72  ? 432 ASN A N   1 
ATOM 2556 C CA  . ASN A 1 458 ? 130.503 158.835 112.392 1.00 72.72  ? 432 ASN A CA  1 
ATOM 2557 C C   . ASN A 1 458 ? 129.640 159.850 113.125 1.00 72.72  ? 432 ASN A C   1 
ATOM 2558 O O   . ASN A 1 458 ? 128.923 160.643 112.508 1.00 72.72  ? 432 ASN A O   1 
ATOM 2559 C CB  . ASN A 1 458 ? 131.896 159.426 112.184 1.00 72.72  ? 432 ASN A CB  1 
ATOM 2560 C CG  . ASN A 1 458 ? 132.824 158.494 111.449 1.00 72.72  ? 432 ASN A CG  1 
ATOM 2561 O OD1 . ASN A 1 458 ? 133.568 157.733 112.067 1.00 72.72  ? 432 ASN A OD1 1 
ATOM 2562 N ND2 . ASN A 1 458 ? 132.806 158.562 110.122 1.00 72.72  ? 432 ASN A ND2 1 
ATOM 2563 N N   . LYS A 1 459 ? 129.717 159.815 114.452 1.00 78.29  ? 433 LYS A N   1 
ATOM 2564 C CA  . LYS A 1 459 ? 129.028 160.792 115.276 1.00 78.29  ? 433 LYS A CA  1 
ATOM 2565 C C   . LYS A 1 459 ? 129.652 162.167 115.099 1.00 78.29  ? 433 LYS A C   1 
ATOM 2566 O O   . LYS A 1 459 ? 130.872 162.314 115.000 1.00 78.29  ? 433 LYS A O   1 
ATOM 2567 C CB  . LYS A 1 459 ? 129.094 160.401 116.749 1.00 78.29  ? 433 LYS A CB  1 
ATOM 2568 C CG  . LYS A 1 459 ? 128.169 159.268 117.159 1.00 78.29  ? 433 LYS A CG  1 
ATOM 2569 C CD  . LYS A 1 459 ? 128.793 158.323 118.195 1.00 78.29  ? 433 LYS A CD  1 
ATOM 2570 C CE  . LYS A 1 459 ? 129.777 159.021 119.133 1.00 78.29  ? 433 LYS A CE  1 
ATOM 2571 N NZ  . LYS A 1 459 ? 130.422 158.083 120.086 1.00 78.29  ? 433 LYS A NZ  1 
ATOM 2572 N N   . SER A 1 460 ? 128.799 163.179 115.055 1.00 91.59  ? 434 SER A N   1 
ATOM 2573 C CA  . SER A 1 460 ? 129.233 164.568 115.061 1.00 91.59  ? 434 SER A CA  1 
ATOM 2574 C C   . SER A 1 460 ? 129.178 165.063 116.501 1.00 91.59  ? 434 SER A C   1 
ATOM 2575 O O   . SER A 1 460 ? 128.108 165.419 117.003 1.00 91.59  ? 434 SER A O   1 
ATOM 2576 C CB  . SER A 1 460 ? 128.361 165.419 114.143 1.00 91.59  ? 434 SER A CB  1 
ATOM 2577 O OG  . SER A 1 460 ? 127.033 165.483 114.627 1.00 91.59  ? 434 SER A OG  1 
ATOM 2578 N N   . VAL A 1 461 ? 130.330 165.067 117.167 1.00 95.41  ? 435 VAL A N   1 
ATOM 2579 C CA  . VAL A 1 461 ? 130.455 165.552 118.534 1.00 95.41  ? 435 VAL A CA  1 
ATOM 2580 C C   . VAL A 1 461 ? 131.317 166.803 118.501 1.00 95.41  ? 435 VAL A C   1 
ATOM 2581 O O   . VAL A 1 461 ? 132.417 166.787 117.936 1.00 95.41  ? 435 VAL A O   1 
ATOM 2582 C CB  . VAL A 1 461 ? 131.063 164.492 119.470 1.00 95.41  ? 435 VAL A CB  1 
ATOM 2583 C CG1 . VAL A 1 461 ? 130.936 164.934 120.919 1.00 95.41  ? 435 VAL A CG1 1 
ATOM 2584 C CG2 . VAL A 1 461 ? 130.402 163.142 119.255 1.00 95.41  ? 435 VAL A CG2 1 
ATOM 2585 N N   . ALA A 1 462 ? 130.812 167.885 119.091 1.00 98.71  ? 436 ALA A N   1 
ATOM 2586 C CA  . ALA A 1 462 ? 131.524 169.157 119.073 1.00 98.71  ? 436 ALA A CA  1 
ATOM 2587 C C   . ALA A 1 462 ? 132.751 169.091 119.970 1.00 98.71  ? 436 ALA A C   1 
ATOM 2588 O O   . ALA A 1 462 ? 132.661 168.698 121.135 1.00 98.71  ? 436 ALA A O   1 
ATOM 2589 C CB  . ALA A 1 462 ? 130.601 170.288 119.523 1.00 98.71  ? 436 ALA A CB  1 
ATOM 2590 N N   . GLY A 1 463 ? 133.898 169.483 119.427 1.00 97.41  ? 437 GLY A N   1 
ATOM 2591 C CA  . GLY A 1 463 ? 135.135 169.425 120.167 1.00 97.41  ? 437 GLY A CA  1 
ATOM 2592 C C   . GLY A 1 463 ? 135.880 168.113 120.084 1.00 97.41  ? 437 GLY A C   1 
ATOM 2593 O O   . GLY A 1 463 ? 136.946 167.989 120.699 1.00 97.41  ? 437 GLY A O   1 
ATOM 2594 N N   . LEU A 1 464 ? 135.356 167.123 119.364 1.00 92.83  ? 438 LEU A N   1 
ATOM 2595 C CA  . LEU A 1 464 ? 136.055 165.856 119.184 1.00 92.83  ? 438 LEU A CA  1 
ATOM 2596 C C   . LEU A 1 464 ? 136.334 165.545 117.723 1.00 92.83  ? 438 LEU A C   1 
ATOM 2597 O O   . LEU A 1 464 ? 137.476 165.229 117.371 1.00 92.83  ? 438 LEU A O   1 
ATOM 2598 C CB  . LEU A 1 464 ? 135.251 164.716 119.825 1.00 92.83  ? 438 LEU A CB  1 
ATOM 2599 C CG  . LEU A 1 464 ? 135.109 164.814 121.343 1.00 92.83  ? 438 LEU A CG  1 
ATOM 2600 C CD1 . LEU A 1 464 ? 134.329 163.637 121.894 1.00 92.83  ? 438 LEU A CD1 1 
ATOM 2601 C CD2 . LEU A 1 464 ? 136.468 164.915 122.007 1.00 92.83  ? 438 LEU A CD2 1 
ATOM 2602 N N   . THR A 1 465 ? 135.323 165.628 116.858 1.00 97.65  ? 439 THR A N   1 
ATOM 2603 C CA  . THR A 1 465 ? 135.501 165.413 115.429 1.00 97.65  ? 439 THR A CA  1 
ATOM 2604 C C   . THR A 1 465 ? 135.489 166.705 114.629 1.00 97.65  ? 439 THR A C   1 
ATOM 2605 O O   . THR A 1 465 ? 136.014 166.730 113.512 1.00 97.65  ? 439 THR A O   1 
ATOM 2606 C CB  . THR A 1 465 ? 134.414 164.476 114.882 1.00 97.65  ? 439 THR A CB  1 
ATOM 2607 O OG1 . THR A 1 465 ? 133.125 165.063 115.096 1.00 97.65  ? 439 THR A OG1 1 
ATOM 2608 C CG2 . THR A 1 465 ? 134.478 163.128 115.579 1.00 97.65  ? 439 THR A CG2 1 
ATOM 2609 N N   . MET A 1 466 ? 134.894 167.764 115.164 1.00 100.15 ? 440 MET A N   1 
ATOM 2610 C CA  . MET A 1 466 ? 134.956 169.087 114.570 1.00 100.15 ? 440 MET A CA  1 
ATOM 2611 C C   . MET A 1 466 ? 135.405 170.051 115.656 1.00 100.15 ? 440 MET A C   1 
ATOM 2612 O O   . MET A 1 466 ? 135.840 169.642 116.735 1.00 100.15 ? 440 MET A O   1 
ATOM 2613 C CB  . MET A 1 466 ? 133.605 169.499 113.980 1.00 100.15 ? 440 MET A CB  1 
ATOM 2614 C CG  . MET A 1 466 ? 133.163 168.672 112.787 1.00 100.15 ? 440 MET A CG  1 
ATOM 2615 S SD  . MET A 1 466 ? 131.598 169.242 112.092 1.00 100.15 ? 440 MET A SD  1 
ATOM 2616 C CE  . MET A 1 466 ? 130.440 168.659 113.329 1.00 100.15 ? 440 MET A CE  1 
ATOM 2617 N N   . THR A 1 467 ? 135.306 171.343 115.362 1.00 103.61 ? 441 THR A N   1 
ATOM 2618 C CA  . THR A 1 467 ? 135.530 172.345 116.390 1.00 103.61 ? 441 THR A CA  1 
ATOM 2619 C C   . THR A 1 467 ? 134.296 172.467 117.281 1.00 103.61 ? 441 THR A C   1 
ATOM 2620 O O   . THR A 1 467 ? 133.285 171.788 117.088 1.00 103.61 ? 441 THR A O   1 
ATOM 2621 C CB  . THR A 1 467 ? 135.871 173.697 115.767 1.00 103.61 ? 441 THR A CB  1 
ATOM 2622 O OG1 . THR A 1 467 ? 134.935 173.996 114.724 1.00 103.61 ? 441 THR A OG1 1 
ATOM 2623 C CG2 . THR A 1 467 ? 137.279 173.683 115.192 1.00 103.61 ? 441 THR A CG2 1 
ATOM 2624 N N   . TYR A 1 468 ? 134.393 173.346 118.280 1.00 102.44 ? 442 TYR A N   1 
ATOM 2625 C CA  . TYR A 1 468 ? 133.294 173.494 119.228 1.00 102.44 ? 442 TYR A CA  1 
ATOM 2626 C C   . TYR A 1 468 ? 132.108 174.224 118.609 1.00 102.44 ? 442 TYR A C   1 
ATOM 2627 O O   . TYR A 1 468 ? 130.961 173.993 119.010 1.00 102.44 ? 442 TYR A O   1 
ATOM 2628 C CB  . TYR A 1 468 ? 133.779 174.219 120.481 1.00 102.44 ? 442 TYR A CB  1 
ATOM 2629 C CG  . TYR A 1 468 ? 134.587 173.344 121.407 1.00 102.44 ? 442 TYR A CG  1 
ATOM 2630 C CD1 . TYR A 1 468 ? 133.965 172.550 122.361 1.00 102.44 ? 442 TYR A CD1 1 
ATOM 2631 C CD2 . TYR A 1 468 ? 135.972 173.306 121.321 1.00 102.44 ? 442 TYR A CD2 1 
ATOM 2632 C CE1 . TYR A 1 468 ? 134.700 171.744 123.209 1.00 102.44 ? 442 TYR A CE1 1 
ATOM 2633 C CE2 . TYR A 1 468 ? 136.718 172.504 122.164 1.00 102.44 ? 442 TYR A CE2 1 
ATOM 2634 C CZ  . TYR A 1 468 ? 136.075 171.725 123.105 1.00 102.44 ? 442 TYR A CZ  1 
ATOM 2635 O OH  . TYR A 1 468 ? 136.813 170.926 123.947 1.00 102.44 ? 442 TYR A OH  1 
ATOM 2636 N N   . ASP A 1 469 ? 132.356 175.103 117.636 1.00 103.05 ? 443 ASP A N   1 
ATOM 2637 C CA  . ASP A 1 469 ? 131.262 175.792 116.964 1.00 103.05 ? 443 ASP A CA  1 
ATOM 2638 C C   . ASP A 1 469 ? 130.659 174.974 115.829 1.00 103.05 ? 443 ASP A C   1 
ATOM 2639 O O   . ASP A 1 469 ? 129.593 175.337 115.321 1.00 103.05 ? 443 ASP A O   1 
ATOM 2640 C CB  . ASP A 1 469 ? 131.733 177.149 116.435 1.00 103.05 ? 443 ASP A CB  1 
ATOM 2641 C CG  . ASP A 1 469 ? 132.821 177.025 115.387 1.00 103.05 ? 443 ASP A CG  1 
ATOM 2642 O OD1 . ASP A 1 469 ? 133.555 176.018 115.401 1.00 103.05 ? 443 ASP A OD1 1 
ATOM 2643 O OD2 . ASP A 1 469 ? 132.944 177.940 114.548 1.00 103.05 ? 443 ASP A OD2 1 
ATOM 2644 N N   . GLY A 1 470 ? 131.314 173.889 115.420 1.00 102.46 ? 444 GLY A N   1 
ATOM 2645 C CA  . GLY A 1 470 ? 130.797 173.044 114.365 1.00 102.46 ? 444 GLY A CA  1 
ATOM 2646 C C   . GLY A 1 470 ? 130.948 173.590 112.965 1.00 102.46 ? 444 GLY A C   1 
ATOM 2647 O O   . GLY A 1 470 ? 130.241 173.130 112.062 1.00 102.46 ? 444 GLY A O   1 
ATOM 2648 N N   . ASN A 1 471 ? 131.842 174.554 112.751 1.00 103.69 ? 445 ASN A N   1 
ATOM 2649 C CA  . ASN A 1 471 ? 131.998 175.159 111.434 1.00 103.69 ? 445 ASN A CA  1 
ATOM 2650 C C   . ASN A 1 471 ? 133.202 174.624 110.671 1.00 103.69 ? 445 ASN A C   1 
ATOM 2651 O O   . ASN A 1 471 ? 133.183 174.609 109.435 1.00 103.69 ? 445 ASN A O   1 
ATOM 2652 C CB  . ASN A 1 471 ? 132.117 176.679 111.565 1.00 103.69 ? 445 ASN A CB  1 
ATOM 2653 C CG  . ASN A 1 471 ? 130.838 177.322 112.059 1.00 103.69 ? 445 ASN A CG  1 
ATOM 2654 O OD1 . ASN A 1 471 ? 129.789 176.681 112.117 1.00 103.69 ? 445 ASN A OD1 1 
ATOM 2655 N ND2 . ASN A 1 471 ? 130.918 178.597 112.420 1.00 103.69 ? 445 ASN A ND2 1 
ATOM 2656 N N   . ASN A 1 472 ? 134.246 174.185 111.372 1.00 101.60 ? 446 ASN A N   1 
ATOM 2657 C CA  . ASN A 1 472 ? 135.466 173.712 110.737 1.00 101.60 ? 446 ASN A CA  1 
ATOM 2658 C C   . ASN A 1 472 ? 135.845 172.353 111.312 1.00 101.60 ? 446 ASN A C   1 
ATOM 2659 O O   . ASN A 1 472 ? 135.880 172.191 112.545 1.00 101.60 ? 446 ASN A O   1 
ATOM 2660 C CB  . ASN A 1 472 ? 136.608 174.716 110.942 1.00 101.60 ? 446 ASN A CB  1 
ATOM 2661 C CG  . ASN A 1 472 ? 137.935 174.208 110.415 1.00 101.60 ? 446 ASN A CG  1 
ATOM 2662 O OD1 . ASN A 1 472 ? 138.003 173.605 109.345 1.00 101.60 ? 446 ASN A OD1 1 
ATOM 2663 N ND2 . ASN A 1 472 ? 139.001 174.449 111.169 1.00 101.60 ? 446 ASN A ND2 1 
ATOM 2664 N N   . PRO A 1 473 ? 136.107 171.353 110.473 1.00 100.93 ? 447 PRO A N   1 
ATOM 2665 C CA  . PRO A 1 473 ? 136.662 170.089 110.974 1.00 100.93 ? 447 PRO A CA  1 
ATOM 2666 C C   . PRO A 1 473 ? 138.078 170.278 111.499 1.00 100.93 ? 447 PRO A C   1 
ATOM 2667 O O   . PRO A 1 473 ? 138.827 171.158 111.070 1.00 100.93 ? 447 PRO A O   1 
ATOM 2668 C CB  . PRO A 1 473 ? 136.638 169.167 109.750 1.00 100.93 ? 447 PRO A CB  1 
ATOM 2669 C CG  . PRO A 1 473 ? 135.666 169.786 108.807 1.00 100.93 ? 447 PRO A CG  1 
ATOM 2670 C CD  . PRO A 1 473 ? 135.688 171.261 109.064 1.00 100.93 ? 447 PRO A CD  1 
ATOM 2671 N N   . VAL A 1 474 ? 138.443 169.424 112.451 1.00 99.72  ? 448 VAL A N   1 
ATOM 2672 C CA  . VAL A 1 474 ? 139.741 169.489 113.109 1.00 99.72  ? 448 VAL A CA  1 
ATOM 2673 C C   . VAL A 1 474 ? 140.702 168.537 112.415 1.00 99.72  ? 448 VAL A C   1 
ATOM 2674 O O   . VAL A 1 474 ? 140.292 167.598 111.724 1.00 99.72  ? 448 VAL A O   1 
ATOM 2675 C CB  . VAL A 1 474 ? 139.643 169.153 114.611 1.00 99.72  ? 448 VAL A CB  1 
ATOM 2676 C CG1 . VAL A 1 474 ? 138.945 170.273 115.362 1.00 99.72  ? 448 VAL A CG1 1 
ATOM 2677 C CG2 . VAL A 1 474 ? 138.915 167.833 114.810 1.00 99.72  ? 448 VAL A CG2 1 
ATOM 2678 N N   . THR A 1 475 ? 141.998 168.797 112.598 1.00 99.26  ? 449 THR A N   1 
ATOM 2679 C CA  . THR A 1 475 ? 143.018 167.897 112.071 1.00 99.26  ? 449 THR A CA  1 
ATOM 2680 C C   . THR A 1 475 ? 143.061 166.588 112.848 1.00 99.26  ? 449 THR A C   1 
ATOM 2681 O O   . THR A 1 475 ? 143.196 165.515 112.249 1.00 99.26  ? 449 THR A O   1 
ATOM 2682 C CB  . THR A 1 475 ? 144.387 168.578 112.103 1.00 99.26  ? 449 THR A CB  1 
ATOM 2683 O OG1 . THR A 1 475 ? 144.261 169.928 111.642 1.00 99.26  ? 449 THR A OG1 1 
ATOM 2684 C CG2 . THR A 1 475 ? 145.373 167.838 111.212 1.00 99.26  ? 449 THR A CG2 1 
ATOM 2685 N N   . SER A 1 476 ? 142.939 166.655 114.168 1.00 96.25  ? 450 SER A N   1 
ATOM 2686 C CA  . SER A 1 476 ? 142.986 165.479 115.030 1.00 96.25  ? 450 SER A CA  1 
ATOM 2687 C C   . SER A 1 476 ? 142.210 165.808 116.299 1.00 96.25  ? 450 SER A C   1 
ATOM 2688 O O   . SER A 1 476 ? 141.690 166.916 116.461 1.00 96.25  ? 450 SER A O   1 
ATOM 2689 C CB  . SER A 1 476 ? 144.427 165.071 115.343 1.00 96.25  ? 450 SER A CB  1 
ATOM 2690 O OG  . SER A 1 476 ? 145.120 166.120 115.998 1.00 96.25  ? 450 SER A OG  1 
ATOM 2691 N N   . HIS A 1 477 ? 142.137 164.835 117.201 1.00 92.25  ? 451 HIS A N   1 
ATOM 2692 C CA  . HIS A 1 477 ? 141.433 165.000 118.464 1.00 92.25  ? 451 HIS A CA  1 
ATOM 2693 C C   . HIS A 1 477 ? 142.361 165.322 119.627 1.00 92.25  ? 451 HIS A C   1 
ATOM 2694 O O   . HIS A 1 477 ? 141.902 165.365 120.772 1.00 92.25  ? 451 HIS A O   1 
ATOM 2695 C CB  . HIS A 1 477 ? 140.623 163.741 118.786 1.00 92.25  ? 451 HIS A CB  1 
ATOM 2696 C CG  . HIS A 1 477 ? 141.438 162.485 118.821 1.00 92.25  ? 451 HIS A CG  1 
ATOM 2697 N ND1 . HIS A 1 477 ? 141.493 161.605 117.762 1.00 92.25  ? 451 HIS A ND1 1 
ATOM 2698 C CD2 . HIS A 1 477 ? 142.219 161.956 119.791 1.00 92.25  ? 451 HIS A CD2 1 
ATOM 2699 C CE1 . HIS A 1 477 ? 142.279 160.591 118.076 1.00 92.25  ? 451 HIS A CE1 1 
ATOM 2700 N NE2 . HIS A 1 477 ? 142.733 160.779 119.301 1.00 92.25  ? 451 HIS A NE2 1 
ATOM 2701 N N   . ARG A 1 478 ? 143.646 165.545 119.367 1.00 97.26  ? 452 ARG A N   1 
ATOM 2702 C CA  . ARG A 1 478 ? 144.618 165.767 120.434 1.00 97.26  ? 452 ARG A CA  1 
ATOM 2703 C C   . ARG A 1 478 ? 144.762 167.264 120.675 1.00 97.26  ? 452 ARG A C   1 
ATOM 2704 O O   . ARG A 1 478 ? 145.358 167.977 119.862 1.00 97.26  ? 452 ARG A O   1 
ATOM 2705 C CB  . ARG A 1 478 ? 145.956 165.131 120.075 1.00 97.26  ? 452 ARG A CB  1 
ATOM 2706 C CG  . ARG A 1 478 ? 145.955 163.607 120.100 1.00 97.26  ? 452 ARG A CG  1 
ATOM 2707 C CD  . ARG A 1 478 ? 145.303 163.059 121.362 1.00 97.26  ? 452 ARG A CD  1 
ATOM 2708 N NE  . ARG A 1 478 ? 146.240 162.997 122.477 1.00 97.26  ? 452 ARG A NE  1 
ATOM 2709 C CZ  . ARG A 1 478 ? 146.050 163.590 123.648 1.00 97.26  ? 452 ARG A CZ  1 
ATOM 2710 N NH1 . ARG A 1 478 ? 144.970 164.313 123.889 1.00 97.26  ? 452 ARG A NH1 1 
ATOM 2711 N NH2 . ARG A 1 478 ? 146.969 163.454 124.600 1.00 97.26  ? 452 ARG A NH2 1 
ATOM 2712 N N   . ASP A 1 479 ? 144.208 167.727 121.803 1.00 102.20 ? 453 ASP A N   1 
ATOM 2713 C CA  . ASP A 1 479 ? 144.317 169.105 122.304 1.00 102.20 ? 453 ASP A CA  1 
ATOM 2714 C C   . ASP A 1 479 ? 143.778 170.122 121.293 1.00 102.20 ? 453 ASP A C   1 
ATOM 2715 O O   . ASP A 1 479 ? 144.503 170.966 120.764 1.00 102.20 ? 453 ASP A O   1 
ATOM 2716 C CB  . ASP A 1 479 ? 145.758 169.434 122.712 1.00 102.20 ? 453 ASP A CB  1 
ATOM 2717 C CG  . ASP A 1 479 ? 145.825 170.373 123.901 1.00 102.20 ? 453 ASP A CG  1 
ATOM 2718 O OD1 . ASP A 1 479 ? 144.883 171.173 124.084 1.00 102.20 ? 453 ASP A OD1 1 
ATOM 2719 O OD2 . ASP A 1 479 ? 146.819 170.311 124.655 1.00 102.20 ? 453 ASP A OD2 1 
ATOM 2720 N N   . VAL A 1 480 ? 142.480 170.014 121.030 1.00 105.07 ? 454 VAL A N   1 
ATOM 2721 C CA  . VAL A 1 480 ? 141.784 170.900 120.100 1.00 105.07 ? 454 VAL A CA  1 
ATOM 2722 C C   . VAL A 1 480 ? 141.629 172.281 120.729 1.00 105.07 ? 454 VAL A C   1 
ATOM 2723 O O   . VAL A 1 480 ? 141.505 172.389 121.958 1.00 105.07 ? 454 VAL A O   1 
ATOM 2724 C CB  . VAL A 1 480 ? 140.423 170.308 119.705 1.00 105.07 ? 454 VAL A CB  1 
ATOM 2725 C CG1 . VAL A 1 480 ? 140.616 169.169 118.721 1.00 105.07 ? 454 VAL A CG1 1 
ATOM 2726 C CG2 . VAL A 1 480 ? 139.686 169.824 120.939 1.00 105.07 ? 454 VAL A CG2 1 
ATOM 2727 N N   . PRO A 1 481 ? 141.650 173.358 119.945 1.00 108.73 ? 455 PRO A N   1 
ATOM 2728 C CA  . PRO A 1 481 ? 141.437 174.690 120.520 1.00 108.73 ? 455 PRO A CA  1 
ATOM 2729 C C   . PRO A 1 481 ? 139.977 174.929 120.874 1.00 108.73 ? 455 PRO A C   1 
ATOM 2730 O O   . PRO A 1 481 ? 139.066 174.248 120.398 1.00 108.73 ? 455 PRO A O   1 
ATOM 2731 C CB  . PRO A 1 481 ? 141.899 175.637 119.407 1.00 108.73 ? 455 PRO A CB  1 
ATOM 2732 C CG  . PRO A 1 481 ? 141.706 174.858 118.157 1.00 108.73 ? 455 PRO A CG  1 
ATOM 2733 C CD  . PRO A 1 481 ? 141.993 173.426 118.513 1.00 108.73 ? 455 PRO A CD  1 
ATOM 2734 N N   . LEU A 1 482 ? 139.767 175.923 121.732 1.00 108.10 ? 456 LEU A N   1 
ATOM 2735 C CA  . LEU A 1 482 ? 138.435 176.281 122.199 1.00 108.10 ? 456 LEU A CA  1 
ATOM 2736 C C   . LEU A 1 482 ? 137.845 177.311 121.231 1.00 108.10 ? 456 LEU A C   1 
ATOM 2737 O O   . LEU A 1 482 ? 138.563 177.938 120.447 1.00 108.10 ? 456 LEU A O   1 
ATOM 2738 C CB  . LEU A 1 482 ? 138.521 176.780 123.642 1.00 108.10 ? 456 LEU A CB  1 
ATOM 2739 C CG  . LEU A 1 482 ? 137.272 177.055 124.483 1.00 108.10 ? 456 LEU A CG  1 
ATOM 2740 C CD1 . LEU A 1 482 ? 136.497 175.765 124.699 1.00 108.10 ? 456 LEU A CD1 1 
ATOM 2741 C CD2 . LEU A 1 482 ? 137.644 177.694 125.809 1.00 108.10 ? 456 LEU A CD2 1 
ATOM 2742 N N   . SER A 1 483 ? 136.527 177.504 121.268 1.00 110.84 ? 457 SER A N   1 
ATOM 2743 C CA  . SER A 1 483 ? 135.845 178.407 120.352 1.00 110.84 ? 457 SER A CA  1 
ATOM 2744 C C   . SER A 1 483 ? 135.418 179.672 121.084 1.00 110.84 ? 457 SER A C   1 
ATOM 2745 O O   . SER A 1 483 ? 135.500 179.767 122.311 1.00 110.84 ? 457 SER A O   1 
ATOM 2746 C CB  . SER A 1 483 ? 134.622 177.742 119.708 1.00 110.84 ? 457 SER A CB  1 
ATOM 2747 O OG  . SER A 1 483 ? 133.937 178.647 118.859 1.00 110.84 ? 457 SER A OG  1 
ATOM 2748 N N   . TYR A 1 484 ? 134.950 180.649 120.303 1.00 112.79 ? 458 TYR A N   1 
ATOM 2749 C CA  . TYR A 1 484 ? 134.573 181.950 120.842 1.00 112.79 ? 458 TYR A CA  1 
ATOM 2750 C C   . TYR A 1 484 ? 133.191 181.957 121.481 1.00 112.79 ? 458 TYR A C   1 
ATOM 2751 O O   . TYR A 1 484 ? 132.842 182.942 122.140 1.00 112.79 ? 458 TYR A O   1 
ATOM 2752 C CB  . TYR A 1 484 ? 134.637 183.014 119.743 1.00 112.79 ? 458 TYR A CB  1 
ATOM 2753 C CG  . TYR A 1 484 ? 133.379 183.121 118.907 1.00 112.79 ? 458 TYR A CG  1 
ATOM 2754 C CD1 . TYR A 1 484 ? 132.999 182.094 118.049 1.00 112.79 ? 458 TYR A CD1 1 
ATOM 2755 C CD2 . TYR A 1 484 ? 132.574 184.254 118.974 1.00 112.79 ? 458 TYR A CD2 1 
ATOM 2756 C CE1 . TYR A 1 484 ? 131.849 182.190 117.284 1.00 112.79 ? 458 TYR A CE1 1 
ATOM 2757 C CE2 . TYR A 1 484 ? 131.422 184.359 118.213 1.00 112.79 ? 458 TYR A CE2 1 
ATOM 2758 C CZ  . TYR A 1 484 ? 131.066 183.324 117.370 1.00 112.79 ? 458 TYR A CZ  1 
ATOM 2759 O OH  . TYR A 1 484 ? 129.922 183.425 116.611 1.00 112.79 ? 458 TYR A OH  1 
ATOM 2760 N N   . CYS A 1 485 ? 132.397 180.898 121.299 1.00 114.49 ? 459 CYS A N   1 
ATOM 2761 C CA  . CYS A 1 485 ? 131.062 180.866 121.890 1.00 114.49 ? 459 CYS A CA  1 
ATOM 2762 C C   . CYS A 1 485 ? 131.115 180.610 123.390 1.00 114.49 ? 459 CYS A C   1 
ATOM 2763 O O   . CYS A 1 485 ? 130.155 180.917 124.105 1.00 114.49 ? 459 CYS A O   1 
ATOM 2764 C CB  . CYS A 1 485 ? 130.206 179.803 121.202 1.00 114.49 ? 459 CYS A CB  1 
ATOM 2765 S SG  . CYS A 1 485 ? 130.916 178.136 121.206 1.00 114.49 ? 459 CYS A SG  1 
ATOM 2766 N N   . ASN A 1 486 ? 132.219 180.053 123.878 1.00 114.06 ? 460 ASN A N   1 
ATOM 2767 C CA  . ASN A 1 486 ? 132.403 179.736 125.290 1.00 114.06 ? 460 ASN A CA  1 
ATOM 2768 C C   . ASN A 1 486 ? 133.787 180.169 125.769 1.00 114.06 ? 460 ASN A C   1 
ATOM 2769 O O   . ASN A 1 486 ? 134.506 179.410 126.427 1.00 114.06 ? 460 ASN A O   1 
ATOM 2770 C CB  . ASN A 1 486 ? 132.117 178.251 125.549 1.00 114.06 ? 460 ASN A CB  1 
ATOM 2771 C CG  . ASN A 1 486 ? 133.002 177.302 124.728 1.00 114.06 ? 460 ASN A CG  1 
ATOM 2772 O OD1 . ASN A 1 486 ? 133.917 177.719 124.016 1.00 114.06 ? 460 ASN A OD1 1 
ATOM 2773 N ND2 . ASN A 1 486 ? 132.714 176.010 124.829 1.00 114.06 ? 460 ASN A ND2 1 
ATOM 2774 N N   . SER A 1 487 ? 134.167 181.412 125.450 1.00 114.82 ? 461 SER A N   1 
ATOM 2775 C CA  . SER A 1 487 ? 135.514 181.891 125.755 1.00 114.82 ? 461 SER A CA  1 
ATOM 2776 C C   . SER A 1 487 ? 135.715 182.154 127.242 1.00 114.82 ? 461 SER A C   1 
ATOM 2777 O O   . SER A 1 487 ? 136.859 182.280 127.695 1.00 114.82 ? 461 SER A O   1 
ATOM 2778 C CB  . SER A 1 487 ? 135.814 183.158 124.955 1.00 114.82 ? 461 SER A CB  1 
ATOM 2779 O OG  . SER A 1 487 ? 136.173 182.846 123.622 1.00 114.82 ? 461 SER A OG  1 
ATOM 2780 N N   . ASP A 1 488 ? 134.629 182.262 128.013 1.00 116.05 ? 462 ASP A N   1 
ATOM 2781 C CA  . ASP A 1 488 ? 134.765 182.401 129.460 1.00 116.05 ? 462 ASP A CA  1 
ATOM 2782 C C   . ASP A 1 488 ? 135.276 181.105 130.076 1.00 116.05 ? 462 ASP A C   1 
ATOM 2783 O O   . ASP A 1 488 ? 136.349 181.081 130.691 1.00 116.05 ? 462 ASP A O   1 
ATOM 2784 C CB  . ASP A 1 488 ? 133.426 182.809 130.075 1.00 116.05 ? 462 ASP A CB  1 
ATOM 2785 C CG  . ASP A 1 488 ? 133.593 183.680 131.306 1.00 116.05 ? 462 ASP A CG  1 
ATOM 2786 O OD1 . ASP A 1 488 ? 134.380 183.306 132.200 1.00 116.05 ? 462 ASP A OD1 1 
ATOM 2787 O OD2 . ASP A 1 488 ? 132.940 184.742 131.376 1.00 116.05 ? 462 ASP A OD2 1 
ATOM 2788 N N   . CYS A 1 489 ? 134.511 180.021 129.910 1.00 114.92 ? 463 CYS A N   1 
ATOM 2789 C CA  . CYS A 1 489 ? 134.928 178.636 130.155 1.00 114.92 ? 463 CYS A CA  1 
ATOM 2790 C C   . CYS A 1 489 ? 135.353 178.395 131.606 1.00 114.92 ? 463 CYS A C   1 
ATOM 2791 O O   . CYS A 1 489 ? 136.509 178.093 131.906 1.00 114.92 ? 463 CYS A O   1 
ATOM 2792 C CB  . CYS A 1 489 ? 136.038 178.224 129.182 1.00 114.92 ? 463 CYS A CB  1 
ATOM 2793 S SG  . CYS A 1 489 ? 136.322 176.439 129.075 1.00 114.92 ? 463 CYS A SG  1 
ATOM 2794 N N   . ASN A 1 490 ? 134.390 178.541 132.513 1.00 114.86 ? 464 ASN A N   1 
ATOM 2795 C CA  . ASN A 1 490 ? 134.582 178.133 133.906 1.00 114.86 ? 464 ASN A CA  1 
ATOM 2796 C C   . ASN A 1 490 ? 134.103 176.692 134.096 1.00 114.86 ? 464 ASN A C   1 
ATOM 2797 O O   . ASN A 1 490 ? 133.256 176.382 134.933 1.00 114.86 ? 464 ASN A O   1 
ATOM 2798 C CB  . ASN A 1 490 ? 133.861 179.091 134.846 1.00 114.86 ? 464 ASN A CB  1 
ATOM 2799 C CG  . ASN A 1 490 ? 134.212 180.540 134.584 1.00 114.86 ? 464 ASN A CG  1 
ATOM 2800 O OD1 . ASN A 1 490 ? 133.385 181.312 134.101 1.00 114.86 ? 464 ASN A OD1 1 
ATOM 2801 N ND2 . ASN A 1 490 ? 135.446 180.917 134.898 1.00 114.86 ? 464 ASN A ND2 1 
ATOM 2802 N N   . CYS A 1 491 ? 134.676 175.806 133.289 1.00 114.58 ? 465 CYS A N   1 
ATOM 2803 C CA  . CYS A 1 491 ? 134.234 174.426 133.162 1.00 114.58 ? 465 CYS A CA  1 
ATOM 2804 C C   . CYS A 1 491 ? 135.409 173.480 133.396 1.00 114.58 ? 465 CYS A C   1 
ATOM 2805 O O   . CYS A 1 491 ? 136.506 173.893 133.781 1.00 114.58 ? 465 CYS A O   1 
ATOM 2806 C CB  . CYS A 1 491 ? 133.611 174.192 131.784 1.00 114.58 ? 465 CYS A CB  1 
ATOM 2807 S SG  . CYS A 1 491 ? 132.520 175.511 131.221 1.00 114.58 ? 465 CYS A SG  1 
ATOM 2808 N N   . ASP A 1 492 ? 135.163 172.194 133.156 1.00 112.29 ? 466 ASP A N   1 
ATOM 2809 C CA  . ASP A 1 492 ? 136.194 171.167 133.203 1.00 112.29 ? 466 ASP A CA  1 
ATOM 2810 C C   . ASP A 1 492 ? 136.130 170.381 131.904 1.00 112.29 ? 466 ASP A C   1 
ATOM 2811 O O   . ASP A 1 492 ? 135.075 169.842 131.554 1.00 112.29 ? 466 ASP A O   1 
ATOM 2812 C CB  . ASP A 1 492 ? 136.002 170.243 134.410 1.00 112.29 ? 466 ASP A CB  1 
ATOM 2813 C CG  . ASP A 1 492 ? 136.936 169.051 134.386 1.00 112.29 ? 466 ASP A CG  1 
ATOM 2814 O OD1 . ASP A 1 492 ? 138.130 169.235 134.067 1.00 112.29 ? 466 ASP A OD1 1 
ATOM 2815 O OD2 . ASP A 1 492 ? 136.478 167.929 134.687 1.00 112.29 ? 466 ASP A OD2 1 
ATOM 2816 N N   . GLU A 1 493 ? 137.255 170.322 131.187 1.00 111.38 ? 467 GLU A N   1 
ATOM 2817 C CA  . GLU A 1 493 ? 137.288 169.596 129.923 1.00 111.38 ? 467 GLU A CA  1 
ATOM 2818 C C   . GLU A 1 493 ? 137.282 168.088 130.138 1.00 111.38 ? 467 GLU A C   1 
ATOM 2819 O O   . GLU A 1 493 ? 136.850 167.339 129.254 1.00 111.38 ? 467 GLU A O   1 
ATOM 2820 C CB  . GLU A 1 493 ? 138.514 170.013 129.111 1.00 111.38 ? 467 GLU A CB  1 
ATOM 2821 C CG  . GLU A 1 493 ? 138.502 171.469 128.676 1.00 111.38 ? 467 GLU A CG  1 
ATOM 2822 C CD  . GLU A 1 493 ? 139.741 171.853 127.891 1.00 111.38 ? 467 GLU A CD  1 
ATOM 2823 O OE1 . GLU A 1 493 ? 140.511 170.945 127.512 1.00 111.38 ? 467 GLU A OE1 1 
ATOM 2824 O OE2 . GLU A 1 493 ? 139.946 173.061 127.653 1.00 111.38 ? 467 GLU A OE2 1 
ATOM 2825 N N   . SER A 1 494 ? 137.758 167.626 131.297 1.00 110.92 ? 468 SER A N   1 
ATOM 2826 C CA  . SER A 1 494 ? 137.786 166.193 131.566 1.00 110.92 ? 468 SER A CA  1 
ATOM 2827 C C   . SER A 1 494 ? 136.404 165.653 131.911 1.00 110.92 ? 468 SER A C   1 
ATOM 2828 O O   . SER A 1 494 ? 136.169 164.445 131.796 1.00 110.92 ? 468 SER A O   1 
ATOM 2829 C CB  . SER A 1 494 ? 138.768 165.890 132.696 1.00 110.92 ? 468 SER A CB  1 
ATOM 2830 O OG  . SER A 1 494 ? 138.192 166.166 133.961 1.00 110.92 ? 468 SER A OG  1 
ATOM 2831 N N   . GLN A 1 495 ? 135.486 166.518 132.337 1.00 107.84 ? 469 GLN A N   1 
ATOM 2832 C CA  . GLN A 1 495 ? 134.147 166.069 132.694 1.00 107.84 ? 469 GLN A CA  1 
ATOM 2833 C C   . GLN A 1 495 ? 133.344 165.757 131.438 1.00 107.84 ? 469 GLN A C   1 
ATOM 2834 O O   . GLN A 1 495 ? 133.294 166.562 130.503 1.00 107.84 ? 469 GLN A O   1 
ATOM 2835 C CB  . GLN A 1 495 ? 133.437 167.131 133.531 1.00 107.84 ? 469 GLN A CB  1 
ATOM 2836 C CG  . GLN A 1 495 ? 132.118 166.670 134.130 1.00 107.84 ? 469 GLN A CG  1 
ATOM 2837 C CD  . GLN A 1 495 ? 131.537 167.677 135.103 1.00 107.84 ? 469 GLN A CD  1 
ATOM 2838 O OE1 . GLN A 1 495 ? 132.247 168.541 135.617 1.00 107.84 ? 469 GLN A OE1 1 
ATOM 2839 N NE2 . GLN A 1 495 ? 130.239 167.570 135.361 1.00 107.84 ? 469 GLN A NE2 1 
ATOM 2840 N N   . TRP A 1 496 ? 132.716 164.584 131.418 1.00 98.92  ? 470 TRP A N   1 
ATOM 2841 C CA  . TRP A 1 496 ? 131.956 164.105 130.266 1.00 98.92  ? 470 TRP A CA  1 
ATOM 2842 C C   . TRP A 1 496 ? 130.499 163.931 130.685 1.00 98.92  ? 470 TRP A C   1 
ATOM 2843 O O   . TRP A 1 496 ? 130.130 162.927 131.298 1.00 98.92  ? 470 TRP A O   1 
ATOM 2844 C CB  . TRP A 1 496 ? 132.540 162.801 129.726 1.00 98.92  ? 470 TRP A CB  1 
ATOM 2845 C CG  . TRP A 1 496 ? 131.698 162.171 128.661 1.00 98.92  ? 470 TRP A CG  1 
ATOM 2846 C CD1 . TRP A 1 496 ? 130.846 161.115 128.805 1.00 98.92  ? 470 TRP A CD1 1 
ATOM 2847 C CD2 . TRP A 1 496 ? 131.630 162.555 127.284 1.00 98.92  ? 470 TRP A CD2 1 
ATOM 2848 N NE1 . TRP A 1 496 ? 130.249 160.822 127.605 1.00 98.92  ? 470 TRP A NE1 1 
ATOM 2849 C CE2 . TRP A 1 496 ? 130.713 161.691 126.654 1.00 98.92  ? 470 TRP A CE2 1 
ATOM 2850 C CE3 . TRP A 1 496 ? 132.254 163.548 126.522 1.00 98.92  ? 470 TRP A CE3 1 
ATOM 2851 C CZ2 . TRP A 1 496 ? 130.403 161.791 125.301 1.00 98.92  ? 470 TRP A CZ2 1 
ATOM 2852 C CZ3 . TRP A 1 496 ? 131.947 163.643 125.177 1.00 98.92  ? 470 TRP A CZ3 1 
ATOM 2853 C CH2 . TRP A 1 496 ? 131.030 162.770 124.581 1.00 98.92  ? 470 TRP A CH2 1 
ATOM 2854 N N   . GLU A 1 497 ? 129.675 164.922 130.355 1.00 102.56 ? 471 GLU A N   1 
ATOM 2855 C CA  . GLU A 1 497 ? 128.225 164.844 130.514 1.00 102.56 ? 471 GLU A CA  1 
ATOM 2856 C C   . GLU A 1 497 ? 127.624 165.236 129.172 1.00 102.56 ? 471 GLU A C   1 
ATOM 2857 O O   . GLU A 1 497 ? 127.392 166.424 128.911 1.00 102.56 ? 471 GLU A O   1 
ATOM 2858 C CB  . GLU A 1 497 ? 127.731 165.746 131.641 1.00 102.56 ? 471 GLU A CB  1 
ATOM 2859 C CG  . GLU A 1 497 ? 126.278 165.514 132.026 1.00 102.56 ? 471 GLU A CG  1 
ATOM 2860 C CD  . GLU A 1 497 ? 125.964 165.985 133.432 1.00 102.56 ? 471 GLU A CD  1 
ATOM 2861 O OE1 . GLU A 1 497 ? 126.473 167.054 133.831 1.00 102.56 ? 471 GLU A OE1 1 
ATOM 2862 O OE2 . GLU A 1 497 ? 125.206 165.288 134.138 1.00 102.56 ? 471 GLU A OE2 1 
ATOM 2863 N N   . PRO A 1 498 ? 127.384 164.267 128.286 1.00 101.72 ? 472 PRO A N   1 
ATOM 2864 C CA  . PRO A 1 498 ? 126.962 164.601 126.919 1.00 101.72 ? 472 PRO A CA  1 
ATOM 2865 C C   . PRO A 1 498 ? 125.540 165.138 126.861 1.00 101.72 ? 472 PRO A C   1 
ATOM 2866 O O   . PRO A 1 498 ? 124.645 164.670 127.569 1.00 101.72 ? 472 PRO A O   1 
ATOM 2867 C CB  . PRO A 1 498 ? 127.079 163.264 126.180 1.00 101.72 ? 472 PRO A CB  1 
ATOM 2868 C CG  . PRO A 1 498 ? 126.921 162.236 127.248 1.00 101.72 ? 472 PRO A CG  1 
ATOM 2869 C CD  . PRO A 1 498 ? 127.550 162.816 128.477 1.00 101.72 ? 472 PRO A CD  1 
ATOM 2870 N N   . VAL A 1 499 ? 125.343 166.139 126.005 1.00 101.04 ? 473 VAL A N   1 
ATOM 2871 C CA  . VAL A 1 499 ? 124.045 166.769 125.796 1.00 101.04 ? 473 VAL A CA  1 
ATOM 2872 C C   . VAL A 1 499 ? 123.751 166.784 124.304 1.00 101.04 ? 473 VAL A C   1 
ATOM 2873 O O   . VAL A 1 499 ? 124.672 166.887 123.486 1.00 101.04 ? 473 VAL A O   1 
ATOM 2874 C CB  . VAL A 1 499 ? 123.990 168.195 126.379 1.00 101.04 ? 473 VAL A CB  1 
ATOM 2875 C CG1 . VAL A 1 499 ? 123.937 168.144 127.895 1.00 101.04 ? 473 VAL A CG1 1 
ATOM 2876 C CG2 . VAL A 1 499 ? 125.192 169.009 125.926 1.00 101.04 ? 473 VAL A CG2 1 
ATOM 2877 N N   . CYS A 1 500 ? 122.474 166.669 123.949 1.00 99.91  ? 474 CYS A N   1 
ATOM 2878 C CA  . CYS A 1 500 ? 122.055 166.600 122.555 1.00 99.91  ? 474 CYS A CA  1 
ATOM 2879 C C   . CYS A 1 500 ? 121.356 167.894 122.165 1.00 99.91  ? 474 CYS A C   1 
ATOM 2880 O O   . CYS A 1 500 ? 120.350 168.268 122.777 1.00 99.91  ? 474 CYS A O   1 
ATOM 2881 C CB  . CYS A 1 500 ? 121.126 165.411 122.320 1.00 99.91  ? 474 CYS A CB  1 
ATOM 2882 S SG  . CYS A 1 500 ? 120.589 165.268 120.607 1.00 99.91  ? 474 CYS A SG  1 
ATOM 2883 N N   . GLY A 1 501 ? 121.873 168.558 121.132 1.00 99.28  ? 475 GLY A N   1 
ATOM 2884 C CA  . GLY A 1 501 ? 121.302 169.801 120.662 1.00 99.28  ? 475 GLY A CA  1 
ATOM 2885 C C   . GLY A 1 501 ? 120.150 169.587 119.698 1.00 99.28  ? 475 GLY A C   1 
ATOM 2886 O O   . GLY A 1 501 ? 119.796 168.467 119.333 1.00 99.28  ? 475 GLY A O   1 
ATOM 2887 N N   . ASN A 1 502 ? 119.557 170.705 119.280 1.00 100.35 ? 476 ASN A N   1 
ATOM 2888 C CA  . ASN A 1 502 ? 118.452 170.664 118.331 1.00 100.35 ? 476 ASN A CA  1 
ATOM 2889 C C   . ASN A 1 502 ? 118.913 170.427 116.900 1.00 100.35 ? 476 ASN A C   1 
ATOM 2890 O O   . ASN A 1 502 ? 118.089 170.071 116.050 1.00 100.35 ? 476 ASN A O   1 
ATOM 2891 C CB  . ASN A 1 502 ? 117.646 171.963 118.400 1.00 100.35 ? 476 ASN A CB  1 
ATOM 2892 C CG  . ASN A 1 502 ? 116.725 172.014 119.603 1.00 100.35 ? 476 ASN A CG  1 
ATOM 2893 O OD1 . ASN A 1 502 ? 116.513 171.008 120.280 1.00 100.35 ? 476 ASN A OD1 1 
ATOM 2894 N ND2 . ASN A 1 502 ? 116.171 173.190 119.875 1.00 100.35 ? 476 ASN A ND2 1 
ATOM 2895 N N   . ASN A 1 503 ? 120.197 170.615 116.613 1.00 98.11  ? 477 ASN A N   1 
ATOM 2896 C CA  . ASN A 1 503 ? 120.725 170.420 115.270 1.00 98.11  ? 477 ASN A CA  1 
ATOM 2897 C C   . ASN A 1 503 ? 121.232 169.005 115.030 1.00 98.11  ? 477 ASN A C   1 
ATOM 2898 O O   . ASN A 1 503 ? 121.754 168.727 113.945 1.00 98.11  ? 477 ASN A O   1 
ATOM 2899 C CB  . ASN A 1 503 ? 121.850 171.423 114.996 1.00 98.11  ? 477 ASN A CB  1 
ATOM 2900 C CG  . ASN A 1 503 ? 123.028 171.250 115.933 1.00 98.11  ? 477 ASN A CG  1 
ATOM 2901 O OD1 . ASN A 1 503 ? 122.888 170.728 117.039 1.00 98.11  ? 477 ASN A OD1 1 
ATOM 2902 N ND2 . ASN A 1 503 ? 124.201 171.690 115.493 1.00 98.11  ? 477 ASN A ND2 1 
ATOM 2903 N N   . GLY A 1 504 ? 121.095 168.111 116.006 1.00 96.56  ? 478 GLY A N   1 
ATOM 2904 C CA  . GLY A 1 504 ? 121.580 166.755 115.874 1.00 96.56  ? 478 GLY A CA  1 
ATOM 2905 C C   . GLY A 1 504 ? 123.038 166.553 116.221 1.00 96.56  ? 478 GLY A C   1 
ATOM 2906 O O   . GLY A 1 504 ? 123.561 165.453 116.004 1.00 96.56  ? 478 GLY A O   1 
ATOM 2907 N N   . ILE A 1 505 ? 123.710 167.569 116.753 1.00 98.16  ? 479 ILE A N   1 
ATOM 2908 C CA  . ILE A 1 505 ? 125.120 167.481 117.111 1.00 98.16  ? 479 ILE A CA  1 
ATOM 2909 C C   . ILE A 1 505 ? 125.223 167.377 118.626 1.00 98.16  ? 479 ILE A C   1 
ATOM 2910 O O   . ILE A 1 505 ? 124.751 168.258 119.354 1.00 98.16  ? 479 ILE A O   1 
ATOM 2911 C CB  . ILE A 1 505 ? 125.913 168.686 116.581 1.00 98.16  ? 479 ILE A CB  1 
ATOM 2912 C CG1 . ILE A 1 505 ? 126.025 168.621 115.057 1.00 98.16  ? 479 ILE A CG1 1 
ATOM 2913 C CG2 . ILE A 1 505 ? 127.297 168.742 117.216 1.00 98.16  ? 479 ILE A CG2 1 
ATOM 2914 C CD1 . ILE A 1 505 ? 126.860 169.730 114.451 1.00 98.16  ? 479 ILE A CD1 1 
ATOM 2915 N N   . THR A 1 506 ? 125.825 166.291 119.098 1.00 98.24  ? 480 THR A N   1 
ATOM 2916 C CA  . THR A 1 506 ? 126.095 166.118 120.515 1.00 98.24  ? 480 THR A CA  1 
ATOM 2917 C C   . THR A 1 506 ? 127.242 167.036 120.933 1.00 98.24  ? 480 THR A C   1 
ATOM 2918 O O   . THR A 1 506 ? 128.165 167.301 120.160 1.00 98.24  ? 480 THR A O   1 
ATOM 2919 C CB  . THR A 1 506 ? 126.432 164.648 120.798 1.00 98.24  ? 480 THR A CB  1 
ATOM 2920 O OG1 . THR A 1 506 ? 125.426 163.814 120.210 1.00 98.24  ? 480 THR A OG1 1 
ATOM 2921 C CG2 . THR A 1 506 ? 126.480 164.347 122.291 1.00 98.24  ? 480 THR A CG2 1 
ATOM 2922 N N   . TYR A 1 507 ? 127.161 167.556 122.152 1.00 100.75 ? 481 TYR A N   1 
ATOM 2923 C CA  . TYR A 1 507 ? 128.236 168.344 122.730 1.00 100.75 ? 481 TYR A CA  1 
ATOM 2924 C C   . TYR A 1 507 ? 128.828 167.580 123.907 1.00 100.75 ? 481 TYR A C   1 
ATOM 2925 O O   . TYR A 1 507 ? 128.186 166.695 124.480 1.00 100.75 ? 481 TYR A O   1 
ATOM 2926 C CB  . TYR A 1 507 ? 127.770 169.750 123.169 1.00 100.75 ? 481 TYR A CB  1 
ATOM 2927 C CG  . TYR A 1 507 ? 127.350 170.704 122.049 1.00 100.75 ? 481 TYR A CG  1 
ATOM 2928 C CD1 . TYR A 1 507 ? 126.295 170.412 121.187 1.00 100.75 ? 481 TYR A CD1 1 
ATOM 2929 C CD2 . TYR A 1 507 ? 128.041 171.893 121.845 1.00 100.75 ? 481 TYR A CD2 1 
ATOM 2930 C CE1 . TYR A 1 507 ? 125.934 171.278 120.170 1.00 100.75 ? 481 TYR A CE1 1 
ATOM 2931 C CE2 . TYR A 1 507 ? 127.686 172.765 120.828 1.00 100.75 ? 481 TYR A CE2 1 
ATOM 2932 C CZ  . TYR A 1 507 ? 126.632 172.451 119.997 1.00 100.75 ? 481 TYR A CZ  1 
ATOM 2933 O OH  . TYR A 1 507 ? 126.276 173.310 118.987 1.00 100.75 ? 481 TYR A OH  1 
ATOM 2934 N N   . ILE A 1 508 ? 130.081 167.915 124.236 1.00 101.63 ? 482 ILE A N   1 
ATOM 2935 C CA  . ILE A 1 508 ? 130.813 167.199 125.283 1.00 101.63 ? 482 ILE A CA  1 
ATOM 2936 C C   . ILE A 1 508 ? 130.176 167.441 126.646 1.00 101.63 ? 482 ILE A C   1 
ATOM 2937 O O   . ILE A 1 508 ? 129.895 166.500 127.398 1.00 101.63 ? 482 ILE A O   1 
ATOM 2938 C CB  . ILE A 1 508 ? 132.295 167.619 125.276 1.00 101.63 ? 482 ILE A CB  1 
ATOM 2939 C CG1 . ILE A 1 508 ? 132.995 167.109 124.019 1.00 101.63 ? 482 ILE A CG1 1 
ATOM 2940 C CG2 . ILE A 1 508 ? 133.011 167.124 126.526 1.00 101.63 ? 482 ILE A CG2 1 
ATOM 2941 C CD1 . ILE A 1 508 ? 134.444 167.530 123.920 1.00 101.63 ? 482 ILE A CD1 1 
ATOM 2942 N N   . SER A 1 509 ? 129.923 168.701 126.973 1.00 104.85 ? 483 SER A N   1 
ATOM 2943 C CA  . SER A 1 509 ? 129.333 169.078 128.246 1.00 104.85 ? 483 SER A CA  1 
ATOM 2944 C C   . SER A 1 509 ? 128.390 170.240 127.996 1.00 104.85 ? 483 SER A C   1 
ATOM 2945 O O   . SER A 1 509 ? 128.546 170.964 127.006 1.00 104.85 ? 483 SER A O   1 
ATOM 2946 C CB  . SER A 1 509 ? 130.414 169.463 129.268 1.00 104.85 ? 483 SER A CB  1 
ATOM 2947 O OG  . SER A 1 509 ? 130.917 170.763 129.016 1.00 104.85 ? 483 SER A OG  1 
ATOM 2948 N N   . PRO A 1 510 ? 127.377 170.429 128.853 1.00 105.09 ? 484 PRO A N   1 
ATOM 2949 C CA  . PRO A 1 510 ? 126.567 171.654 128.743 1.00 105.09 ? 484 PRO A CA  1 
ATOM 2950 C C   . PRO A 1 510 ? 127.353 172.914 129.050 1.00 105.09 ? 484 PRO A C   1 
ATOM 2951 O O   . PRO A 1 510 ? 127.016 173.990 128.541 1.00 105.09 ? 484 PRO A O   1 
ATOM 2952 C CB  . PRO A 1 510 ? 125.438 171.422 129.757 1.00 105.09 ? 484 PRO A CB  1 
ATOM 2953 C CG  . PRO A 1 510 ? 125.964 170.393 130.692 1.00 105.09 ? 484 PRO A CG  1 
ATOM 2954 C CD  . PRO A 1 510 ? 126.836 169.510 129.869 1.00 105.09 ? 484 PRO A CD  1 
ATOM 2955 N N   . CYS A 1 511 ? 128.398 172.806 129.876 1.00 106.60 ? 485 CYS A N   1 
ATOM 2956 C CA  . CYS A 1 511 ? 129.246 173.958 130.161 1.00 106.60 ? 485 CYS A CA  1 
ATOM 2957 C C   . CYS A 1 511 ? 130.067 174.355 128.940 1.00 106.60 ? 485 CYS A C   1 
ATOM 2958 O O   . CYS A 1 511 ? 130.313 175.545 128.711 1.00 106.60 ? 485 CYS A O   1 
ATOM 2959 C CB  . CYS A 1 511 ? 130.151 173.656 131.353 1.00 106.60 ? 485 CYS A CB  1 
ATOM 2960 S SG  . CYS A 1 511 ? 130.779 175.124 132.185 1.00 106.60 ? 485 CYS A SG  1 
ATOM 2961 N N   . LEU A 1 512 ? 130.507 173.375 128.149 1.00 105.26 ? 486 LEU A N   1 
ATOM 2962 C CA  . LEU A 1 512 ? 131.148 173.687 126.877 1.00 105.26 ? 486 LEU A CA  1 
ATOM 2963 C C   . LEU A 1 512 ? 130.137 174.066 125.804 1.00 105.26 ? 486 LEU A C   1 
ATOM 2964 O O   . LEU A 1 512 ? 130.517 174.678 124.800 1.00 105.26 ? 486 LEU A O   1 
ATOM 2965 C CB  . LEU A 1 512 ? 131.985 172.501 126.399 1.00 105.26 ? 486 LEU A CB  1 
ATOM 2966 C CG  . LEU A 1 512 ? 133.304 172.244 127.127 1.00 105.26 ? 486 LEU A CG  1 
ATOM 2967 C CD1 . LEU A 1 512 ? 133.875 170.891 126.734 1.00 105.26 ? 486 LEU A CD1 1 
ATOM 2968 C CD2 . LEU A 1 512 ? 134.303 173.351 126.838 1.00 105.26 ? 486 LEU A CD2 1 
ATOM 2969 N N   . ALA A 1 513 ? 128.862 173.723 125.995 1.00 106.32 ? 487 ALA A N   1 
ATOM 2970 C CA  . ALA A 1 513 ? 127.840 173.997 124.994 1.00 106.32 ? 487 ALA A CA  1 
ATOM 2971 C C   . ALA A 1 513 ? 127.351 175.437 125.020 1.00 106.32 ? 487 ALA A C   1 
ATOM 2972 O O   . ALA A 1 513 ? 126.606 175.834 124.117 1.00 106.32 ? 487 ALA A O   1 
ATOM 2973 C CB  . ALA A 1 513 ? 126.653 173.053 125.187 1.00 106.32 ? 487 ALA A CB  1 
ATOM 2974 N N   . GLY A 1 514 ? 127.744 176.224 126.017 1.00 108.43 ? 488 GLY A N   1 
ATOM 2975 C CA  . GLY A 1 514 ? 127.262 177.580 126.145 1.00 108.43 ? 488 GLY A CA  1 
ATOM 2976 C C   . GLY A 1 514 ? 125.925 177.727 126.834 1.00 108.43 ? 488 GLY A C   1 
ATOM 2977 O O   . GLY A 1 514 ? 125.383 178.839 126.864 1.00 108.43 ? 488 GLY A O   1 
ATOM 2978 N N   . CYS A 1 515 ? 125.372 176.649 127.384 1.00 109.33 ? 489 CYS A N   1 
ATOM 2979 C CA  . CYS A 1 515 ? 124.096 176.738 128.078 1.00 109.33 ? 489 CYS A CA  1 
ATOM 2980 C C   . CYS A 1 515 ? 124.279 177.392 129.442 1.00 109.33 ? 489 CYS A C   1 
ATOM 2981 O O   . CYS A 1 515 ? 125.114 176.970 130.246 1.00 109.33 ? 489 CYS A O   1 
ATOM 2982 C CB  . CYS A 1 515 ? 123.475 175.350 128.226 1.00 109.33 ? 489 CYS A CB  1 
ATOM 2983 S SG  . CYS A 1 515 ? 123.401 174.407 126.684 1.00 109.33 ? 489 CYS A SG  1 
ATOM 2984 N N   . LYS A 1 516 ? 123.487 178.431 129.699 1.00 109.19 ? 490 LYS A N   1 
ATOM 2985 C CA  . LYS A 1 516 ? 123.613 179.225 130.912 1.00 109.19 ? 490 LYS A CA  1 
ATOM 2986 C C   . LYS A 1 516 ? 122.559 178.912 131.961 1.00 109.19 ? 490 LYS A C   1 
ATOM 2987 O O   . LYS A 1 516 ? 122.799 179.152 133.146 1.00 109.19 ? 490 LYS A O   1 
ATOM 2988 C CB  . LYS A 1 516 ? 123.547 180.719 130.573 1.00 109.19 ? 490 LYS A CB  1 
ATOM 2989 C CG  . LYS A 1 516 ? 124.633 181.179 129.612 1.00 109.19 ? 490 LYS A CG  1 
ATOM 2990 C CD  . LYS A 1 516 ? 124.485 182.653 129.272 1.00 109.19 ? 490 LYS A CD  1 
ATOM 2991 C CE  . LYS A 1 516 ? 125.544 183.098 128.278 1.00 109.19 ? 490 LYS A CE  1 
ATOM 2992 N NZ  . LYS A 1 516 ? 125.392 184.533 127.910 1.00 109.19 ? 490 LYS A NZ  1 
ATOM 2993 N N   . SER A 1 517 ? 121.404 178.388 131.558 1.00 109.44 ? 491 SER A N   1 
ATOM 2994 C CA  . SER A 1 517 ? 120.344 178.035 132.489 1.00 109.44 ? 491 SER A CA  1 
ATOM 2995 C C   . SER A 1 517 ? 119.788 176.668 132.124 1.00 109.44 ? 491 SER A C   1 
ATOM 2996 O O   . SER A 1 517 ? 119.845 176.246 130.966 1.00 109.44 ? 491 SER A O   1 
ATOM 2997 C CB  . SER A 1 517 ? 119.218 179.077 132.487 1.00 109.44 ? 491 SER A CB  1 
ATOM 2998 O OG  . SER A 1 517 ? 118.580 179.133 131.223 1.00 109.44 ? 491 SER A OG  1 
ATOM 2999 N N   . SER A 1 518 ? 119.250 175.981 133.124 1.00 108.13 ? 492 SER A N   1 
ATOM 3000 C CA  . SER A 1 518 ? 118.665 174.662 132.919 1.00 108.13 ? 492 SER A CA  1 
ATOM 3001 C C   . SER A 1 518 ? 117.199 174.648 133.335 1.00 108.13 ? 492 SER A C   1 
ATOM 3002 O O   . SER A 1 518 ? 116.621 175.691 133.639 1.00 108.13 ? 492 SER A O   1 
ATOM 3003 C CB  . SER A 1 518 ? 119.445 173.601 133.697 1.00 108.13 ? 492 SER A CB  1 
ATOM 3004 O OG  . SER A 1 518 ? 118.856 172.321 133.543 1.00 108.13 ? 492 SER A OG  1 
ATOM 3005 N N   . PHE A 1 527 ? 118.022 172.514 129.103 1.00 107.60 ? 501 PHE A N   1 
ATOM 3006 C CA  . PHE A 1 527 ? 119.025 173.571 129.058 1.00 107.60 ? 501 PHE A CA  1 
ATOM 3007 C C   . PHE A 1 527 ? 118.602 174.669 128.090 1.00 107.60 ? 501 PHE A C   1 
ATOM 3008 O O   . PHE A 1 527 ? 118.158 174.389 126.977 1.00 107.60 ? 501 PHE A O   1 
ATOM 3009 C CB  . PHE A 1 527 ? 120.390 173.004 128.661 1.00 107.60 ? 501 PHE A CB  1 
ATOM 3010 C CG  . PHE A 1 527 ? 120.985 172.082 129.688 1.00 107.60 ? 501 PHE A CG  1 
ATOM 3011 C CD1 . PHE A 1 527 ? 120.721 170.720 129.656 1.00 107.60 ? 501 PHE A CD1 1 
ATOM 3012 C CD2 . PHE A 1 527 ? 121.807 172.579 130.688 1.00 107.60 ? 501 PHE A CD2 1 
ATOM 3013 C CE1 . PHE A 1 527 ? 121.265 169.870 130.602 1.00 107.60 ? 501 PHE A CE1 1 
ATOM 3014 C CE2 . PHE A 1 527 ? 122.355 171.734 131.638 1.00 107.60 ? 501 PHE A CE2 1 
ATOM 3015 C CZ  . PHE A 1 527 ? 122.084 170.377 131.594 1.00 107.60 ? 501 PHE A CZ  1 
ATOM 3016 N N   . TYR A 1 528 ? 118.746 175.921 128.519 1.00 109.66 ? 502 TYR A N   1 
ATOM 3017 C CA  . TYR A 1 528 ? 118.282 177.066 127.752 1.00 109.66 ? 502 TYR A CA  1 
ATOM 3018 C C   . TYR A 1 528 ? 119.429 178.038 127.518 1.00 109.66 ? 502 TYR A C   1 
ATOM 3019 O O   . TYR A 1 528 ? 120.385 178.089 128.298 1.00 109.66 ? 502 TYR A O   1 
ATOM 3020 C CB  . TYR A 1 528 ? 117.132 177.791 128.466 1.00 109.66 ? 502 TYR A CB  1 
ATOM 3021 C CG  . TYR A 1 528 ? 116.049 176.872 128.980 1.00 109.66 ? 502 TYR A CG  1 
ATOM 3022 C CD1 . TYR A 1 528 ? 115.054 176.397 128.133 1.00 109.66 ? 502 TYR A CD1 1 
ATOM 3023 C CD2 . TYR A 1 528 ? 116.016 176.483 130.315 1.00 109.66 ? 502 TYR A CD2 1 
ATOM 3024 C CE1 . TYR A 1 528 ? 114.057 175.556 128.600 1.00 109.66 ? 502 TYR A CE1 1 
ATOM 3025 C CE2 . TYR A 1 528 ? 115.024 175.643 130.792 1.00 109.66 ? 502 TYR A CE2 1 
ATOM 3026 C CZ  . TYR A 1 528 ? 114.048 175.183 129.930 1.00 109.66 ? 502 TYR A CZ  1 
ATOM 3027 O OH  . TYR A 1 528 ? 113.061 174.348 130.400 1.00 109.66 ? 502 TYR A OH  1 
ATOM 3028 N N   . ASN A 1 529 ? 119.306 178.802 126.421 1.00 110.82 ? 503 ASN A N   1 
ATOM 3029 C CA  . ASN A 1 529 ? 120.246 179.857 126.020 1.00 110.82 ? 503 ASN A CA  1 
ATOM 3030 C C   . ASN A 1 529 ? 121.666 179.317 125.839 1.00 110.82 ? 503 ASN A C   1 
ATOM 3031 O O   . ASN A 1 529 ? 122.611 179.749 126.501 1.00 110.82 ? 503 ASN A O   1 
ATOM 3032 C CB  . ASN A 1 529 ? 120.224 181.032 127.005 1.00 110.82 ? 503 ASN A CB  1 
ATOM 3033 C CG  . ASN A 1 529 ? 118.906 181.782 126.988 1.00 110.82 ? 503 ASN A CG  1 
ATOM 3034 O OD1 . ASN A 1 529 ? 118.164 181.734 126.007 1.00 110.82 ? 503 ASN A OD1 1 
ATOM 3035 N ND2 . ASN A 1 529 ? 118.608 182.481 128.077 1.00 110.82 ? 503 ASN A ND2 1 
ATOM 3036 N N   . CYS A 1 530 ? 121.809 178.360 124.926 1.00 111.50 ? 504 CYS A N   1 
ATOM 3037 C CA  . CYS A 1 530 ? 123.099 177.739 124.648 1.00 111.50 ? 504 CYS A CA  1 
ATOM 3038 C C   . CYS A 1 530 ? 123.780 178.499 123.516 1.00 111.50 ? 504 CYS A C   1 
ATOM 3039 O O   . CYS A 1 530 ? 123.228 178.622 122.417 1.00 111.50 ? 504 CYS A O   1 
ATOM 3040 C CB  . CYS A 1 530 ? 122.922 176.261 124.315 1.00 111.50 ? 504 CYS A CB  1 
ATOM 3041 S SG  . CYS A 1 530 ? 121.984 175.344 125.567 1.00 111.50 ? 504 CYS A SG  1 
ATOM 3042 N N   . SER A 1 531 ? 124.983 179.009 123.791 1.00 111.38 ? 505 SER A N   1 
ATOM 3043 C CA  . SER A 1 531 ? 125.648 179.909 122.854 1.00 111.38 ? 505 SER A CA  1 
ATOM 3044 C C   . SER A 1 531 ? 126.210 179.161 121.652 1.00 111.38 ? 505 SER A C   1 
ATOM 3045 O O   . SER A 1 531 ? 126.130 179.651 120.520 1.00 111.38 ? 505 SER A O   1 
ATOM 3046 C CB  . SER A 1 531 ? 126.758 180.679 123.570 1.00 111.38 ? 505 SER A CB  1 
ATOM 3047 O OG  . SER A 1 531 ? 126.220 181.605 124.497 1.00 111.38 ? 505 SER A OG  1 
ATOM 3048 N N   . CYS A 1 532 ? 126.776 177.973 121.872 1.00 111.47 ? 506 CYS A N   1 
ATOM 3049 C CA  . CYS A 1 532 ? 127.471 177.278 120.794 1.00 111.47 ? 506 CYS A CA  1 
ATOM 3050 C C   . CYS A 1 532 ? 126.520 176.556 119.848 1.00 111.47 ? 506 CYS A C   1 
ATOM 3051 O O   . CYS A 1 532 ? 126.968 176.037 118.821 1.00 111.47 ? 506 CYS A O   1 
ATOM 3052 C CB  . CYS A 1 532 ? 128.489 176.297 121.372 1.00 111.47 ? 506 CYS A CB  1 
ATOM 3053 S SG  . CYS A 1 532 ? 129.721 177.068 122.457 1.00 111.47 ? 506 CYS A SG  1 
ATOM 3054 N N   . LEU A 1 533 ? 125.225 176.510 120.166 1.00 110.18 ? 507 LEU A N   1 
ATOM 3055 C CA  . LEU A 1 533 ? 124.250 175.970 119.225 1.00 110.18 ? 507 LEU A CA  1 
ATOM 3056 C C   . LEU A 1 533 ? 123.990 176.912 118.059 1.00 110.18 ? 507 LEU A C   1 
ATOM 3057 O O   . LEU A 1 533 ? 123.508 176.463 117.013 1.00 110.18 ? 507 LEU A O   1 
ATOM 3058 C CB  . LEU A 1 533 ? 122.933 175.662 119.941 1.00 110.18 ? 507 LEU A CB  1 
ATOM 3059 C CG  . LEU A 1 533 ? 122.696 174.221 120.401 1.00 110.18 ? 507 LEU A CG  1 
ATOM 3060 C CD1 . LEU A 1 533 ? 123.616 173.844 121.550 1.00 110.18 ? 507 LEU A CD1 1 
ATOM 3061 C CD2 . LEU A 1 533 ? 121.239 174.015 120.792 1.00 110.18 ? 507 LEU A CD2 1 
ATOM 3062 N N   . GLU A 1 534 ? 124.299 178.198 118.213 1.00 109.60 ? 508 GLU A N   1 
ATOM 3063 C CA  . GLU A 1 534 ? 124.044 179.188 117.172 1.00 109.60 ? 508 GLU A CA  1 
ATOM 3064 C C   . GLU A 1 534 ? 125.043 179.006 116.037 1.00 109.60 ? 508 GLU A C   1 
ATOM 3065 O O   . GLU A 1 534 ? 126.257 178.992 116.262 1.00 109.60 ? 508 GLU A O   1 
ATOM 3066 C CB  . GLU A 1 534 ? 124.131 180.594 117.758 1.00 109.60 ? 508 GLU A CB  1 
ATOM 3067 C CG  . GLU A 1 534 ? 123.599 181.687 116.848 1.00 109.60 ? 508 GLU A CG  1 
ATOM 3068 C CD  . GLU A 1 534 ? 123.453 183.015 117.563 1.00 109.60 ? 508 GLU A CD  1 
ATOM 3069 O OE1 . GLU A 1 534 ? 124.118 183.208 118.603 1.00 109.60 ? 508 GLU A OE1 1 
ATOM 3070 O OE2 . GLU A 1 534 ? 122.674 183.867 117.086 1.00 109.60 ? 508 GLU A OE2 1 
ATOM 3071 N N   . VAL A 1 535 ? 124.535 178.863 114.818 1.00 107.93 ? 509 VAL A N   1 
ATOM 3072 C CA  . VAL A 1 535 ? 125.384 178.671 113.651 1.00 107.93 ? 509 VAL A CA  1 
ATOM 3073 C C   . VAL A 1 535 ? 125.781 180.017 113.057 1.00 107.93 ? 509 VAL A C   1 
ATOM 3074 O O   . VAL A 1 535 ? 124.923 180.836 112.727 1.00 107.93 ? 509 VAL A O   1 
ATOM 3075 C CB  . VAL A 1 535 ? 124.687 177.796 112.597 1.00 107.93 ? 509 VAL A CB  1 
ATOM 3076 C CG1 . VAL A 1 535 ? 125.659 177.430 111.486 1.00 107.93 ? 509 VAL A CG1 1 
ATOM 3077 C CG2 . VAL A 1 535 ? 124.109 176.546 113.243 1.00 107.93 ? 509 VAL A CG2 1 
ATOM 3078 N N   . ALA A 1 545 ? 118.581 172.052 123.935 1.00 104.20 ? 519 ALA A N   1 
ATOM 3079 C CA  . ALA A 1 545 ? 119.636 171.111 124.292 1.00 104.20 ? 519 ALA A CA  1 
ATOM 3080 C C   . ALA A 1 545 ? 119.209 170.225 125.456 1.00 104.20 ? 519 ALA A C   1 
ATOM 3081 O O   . ALA A 1 545 ? 119.102 170.686 126.590 1.00 104.20 ? 519 ALA A O   1 
ATOM 3082 C CB  . ALA A 1 545 ? 120.917 171.854 124.634 1.00 104.20 ? 519 ALA A CB  1 
ATOM 3083 N N   . HIS A 1 546 ? 118.968 168.951 125.170 1.00 104.52 ? 520 HIS A N   1 
ATOM 3084 C CA  . HIS A 1 546 ? 118.537 167.990 126.173 1.00 104.52 ? 520 HIS A CA  1 
ATOM 3085 C C   . HIS A 1 546 ? 119.720 167.171 126.676 1.00 104.52 ? 520 HIS A C   1 
ATOM 3086 O O   . HIS A 1 546 ? 120.757 167.062 126.019 1.00 104.52 ? 520 HIS A O   1 
ATOM 3087 C CB  . HIS A 1 546 ? 117.462 167.057 125.609 1.00 104.52 ? 520 HIS A CB  1 
ATOM 3088 C CG  . HIS A 1 546 ? 116.159 167.737 125.326 1.00 104.52 ? 520 HIS A CG  1 
ATOM 3089 N ND1 . HIS A 1 546 ? 115.892 168.362 124.127 1.00 104.52 ? 520 HIS A ND1 1 
ATOM 3090 C CD2 . HIS A 1 546 ? 115.050 167.892 126.086 1.00 104.52 ? 520 HIS A CD2 1 
ATOM 3091 C CE1 . HIS A 1 546 ? 114.673 168.871 124.161 1.00 104.52 ? 520 HIS A CE1 1 
ATOM 3092 N NE2 . HIS A 1 546 ? 114.141 168.600 125.339 1.00 104.52 ? 520 HIS A NE2 1 
ATOM 3093 N N   . LEU A 1 547 ? 119.547 166.594 127.861 1.00 103.64 ? 521 LEU A N   1 
ATOM 3094 C CA  . LEU A 1 547 ? 120.574 165.747 128.447 1.00 103.64 ? 521 LEU A CA  1 
ATOM 3095 C C   . LEU A 1 547 ? 120.647 164.410 127.714 1.00 103.64 ? 521 LEU A C   1 
ATOM 3096 O O   . LEU A 1 547 ? 119.636 163.866 127.264 1.00 103.64 ? 521 LEU A O   1 
ATOM 3097 C CB  . LEU A 1 547 ? 120.290 165.522 129.933 1.00 103.64 ? 521 LEU A CB  1 
ATOM 3098 C CG  . LEU A 1 547 ? 121.392 164.904 130.797 1.00 103.64 ? 521 LEU A CG  1 
ATOM 3099 C CD1 . LEU A 1 547 ? 122.558 165.868 130.949 1.00 103.64 ? 521 LEU A CD1 1 
ATOM 3100 C CD2 . LEU A 1 547 ? 120.844 164.501 132.158 1.00 103.64 ? 521 LEU A CD2 1 
ATOM 3101 N N   . GLY A 1 548 ? 121.861 163.885 127.594 1.00 101.11 ? 522 GLY A N   1 
ATOM 3102 C CA  . GLY A 1 548 ? 122.081 162.622 126.924 1.00 101.11 ? 522 GLY A CA  1 
ATOM 3103 C C   . GLY A 1 548 ? 122.568 162.798 125.496 1.00 101.11 ? 522 GLY A C   1 
ATOM 3104 O O   . GLY A 1 548 ? 122.512 163.878 124.911 1.00 101.11 ? 522 GLY A O   1 
ATOM 3105 N N   . GLU A 1 549 ? 123.062 161.700 124.933 1.00 95.47  ? 523 GLU A N   1 
ATOM 3106 C CA  . GLU A 1 549 ? 123.579 161.718 123.574 1.00 95.47  ? 523 GLU A CA  1 
ATOM 3107 C C   . GLU A 1 549 ? 122.429 161.716 122.568 1.00 95.47  ? 523 GLU A C   1 
ATOM 3108 O O   . GLU A 1 549 ? 121.311 161.284 122.863 1.00 95.47  ? 523 GLU A O   1 
ATOM 3109 C CB  . GLU A 1 549 ? 124.499 160.518 123.344 1.00 95.47  ? 523 GLU A CB  1 
ATOM 3110 C CG  . GLU A 1 549 ? 125.544 160.722 122.261 1.00 95.47  ? 523 GLU A CG  1 
ATOM 3111 C CD  . GLU A 1 549 ? 126.491 159.554 122.140 1.00 95.47  ? 523 GLU A CD  1 
ATOM 3112 O OE1 . GLU A 1 549 ? 126.241 158.512 122.780 1.00 95.47  ? 523 GLU A OE1 1 
ATOM 3113 O OE2 . GLU A 1 549 ? 127.493 159.682 121.409 1.00 95.47  ? 523 GLU A OE2 1 
ATOM 3114 N N   . CYS A 1 550 ? 122.713 162.223 121.372 1.00 94.94  ? 524 CYS A N   1 
ATOM 3115 C CA  . CYS A 1 550 ? 121.709 162.260 120.314 1.00 94.94  ? 524 CYS A CA  1 
ATOM 3116 C C   . CYS A 1 550 ? 121.429 160.858 119.784 1.00 94.94  ? 524 CYS A C   1 
ATOM 3117 O O   . CYS A 1 550 ? 122.368 160.142 119.417 1.00 94.94  ? 524 CYS A O   1 
ATOM 3118 C CB  . CYS A 1 550 ? 122.166 163.161 119.169 1.00 94.94  ? 524 CYS A CB  1 
ATOM 3119 S SG  . CYS A 1 550 ? 122.310 164.899 119.600 1.00 94.94  ? 524 CYS A SG  1 
ATOM 3120 N N   . PRO A 1 551 ? 120.170 160.425 119.750 1.00 88.98  ? 525 PRO A N   1 
ATOM 3121 C CA  . PRO A 1 551 ? 119.831 159.215 118.996 1.00 88.98  ? 525 PRO A CA  1 
ATOM 3122 C C   . PRO A 1 551 ? 120.023 159.451 117.507 1.00 88.98  ? 525 PRO A C   1 
ATOM 3123 O O   . PRO A 1 551 ? 119.800 160.551 116.996 1.00 88.98  ? 525 PRO A O   1 
ATOM 3124 C CB  . PRO A 1 551 ? 118.358 158.977 119.346 1.00 88.98  ? 525 PRO A CB  1 
ATOM 3125 C CG  . PRO A 1 551 ? 117.845 160.321 119.729 1.00 88.98  ? 525 PRO A CG  1 
ATOM 3126 C CD  . PRO A 1 551 ? 118.990 161.027 120.393 1.00 88.98  ? 525 PRO A CD  1 
ATOM 3127 N N   . ARG A 1 552 ? 120.448 158.404 116.808 1.00 79.28  ? 526 ARG A N   1 
ATOM 3128 C CA  . ARG A 1 552 ? 120.836 158.550 115.417 1.00 79.28  ? 526 ARG A CA  1 
ATOM 3129 C C   . ARG A 1 552 ? 119.633 158.358 114.498 1.00 79.28  ? 526 ARG A C   1 
ATOM 3130 O O   . ARG A 1 552 ? 118.488 158.237 114.939 1.00 79.28  ? 526 ARG A O   1 
ATOM 3131 C CB  . ARG A 1 552 ? 121.965 157.580 115.077 1.00 79.28  ? 526 ARG A CB  1 
ATOM 3132 C CG  . ARG A 1 552 ? 122.950 157.374 116.213 1.00 79.28  ? 526 ARG A CG  1 
ATOM 3133 C CD  . ARG A 1 552 ? 123.936 156.238 115.907 1.00 79.28  ? 526 ARG A CD  1 
ATOM 3134 N NE  . ARG A 1 552 ? 124.606 156.325 114.608 1.00 79.28  ? 526 ARG A NE  1 
ATOM 3135 C CZ  . ARG A 1 552 ? 125.406 157.303 114.192 1.00 79.28  ? 526 ARG A CZ  1 
ATOM 3136 N NH1 . ARG A 1 552 ? 125.801 158.278 114.995 1.00 79.28  ? 526 ARG A NH1 1 
ATOM 3137 N NH2 . ARG A 1 552 ? 125.862 157.279 112.944 1.00 79.28  ? 526 ARG A NH2 1 
ATOM 3138 N N   . ASP A 1 553 ? 119.902 158.344 113.195 1.00 84.55  ? 527 ASP A N   1 
ATOM 3139 C CA  . ASP A 1 553 ? 118.849 158.214 112.200 1.00 84.55  ? 527 ASP A CA  1 
ATOM 3140 C C   . ASP A 1 553 ? 118.306 156.791 112.160 1.00 84.55  ? 527 ASP A C   1 
ATOM 3141 O O   . ASP A 1 553 ? 118.947 155.839 112.612 1.00 84.55  ? 527 ASP A O   1 
ATOM 3142 C CB  . ASP A 1 553 ? 119.371 158.600 110.817 1.00 84.55  ? 527 ASP A CB  1 
ATOM 3143 C CG  . ASP A 1 553 ? 119.689 160.075 110.706 1.00 84.55  ? 527 ASP A CG  1 
ATOM 3144 O OD1 . ASP A 1 553 ? 119.050 160.877 111.419 1.00 84.55  ? 527 ASP A OD1 1 
ATOM 3145 O OD2 . ASP A 1 553 ? 120.575 160.431 109.901 1.00 84.55  ? 527 ASP A OD2 1 
ATOM 3146 N N   . ASP A 1 554 ? 117.102 156.654 111.599 1.00 81.36  ? 528 ASP A N   1 
ATOM 3147 C CA  . ASP A 1 554 ? 116.527 155.334 111.371 1.00 81.36  ? 528 ASP A CA  1 
ATOM 3148 C C   . ASP A 1 554 ? 117.206 154.604 110.219 1.00 81.36  ? 528 ASP A C   1 
ATOM 3149 O O   . ASP A 1 554 ? 117.049 153.380 110.099 1.00 81.36  ? 528 ASP A O   1 
ATOM 3150 C CB  . ASP A 1 554 ? 115.026 155.458 111.103 1.00 81.36  ? 528 ASP A CB  1 
ATOM 3151 C CG  . ASP A 1 554 ? 114.299 156.216 112.198 1.00 81.36  ? 528 ASP A CG  1 
ATOM 3152 O OD1 . ASP A 1 554 ? 114.727 156.129 113.368 1.00 81.36  ? 528 ASP A OD1 1 
ATOM 3153 O OD2 . ASP A 1 554 ? 113.301 156.901 111.889 1.00 81.36  ? 528 ASP A OD2 1 
ATOM 3154 N N   . ALA A 1 555 ? 117.961 155.335 109.387 1.00 79.67  ? 529 ALA A N   1 
ATOM 3155 C CA  . ALA A 1 555 ? 118.629 154.751 108.229 1.00 79.67  ? 529 ALA A CA  1 
ATOM 3156 C C   . ALA A 1 555 ? 119.670 153.718 108.640 1.00 79.67  ? 529 ALA A C   1 
ATOM 3157 O O   . ALA A 1 555 ? 119.813 152.680 107.983 1.00 79.67  ? 529 ALA A O   1 
ATOM 3158 C CB  . ALA A 1 555 ? 119.274 155.854 107.389 1.00 79.67  ? 529 ALA A CB  1 
ATOM 3159 N N   . CYS A 1 556 ? 120.408 153.976 109.718 1.00 74.98  ? 530 CYS A N   1 
ATOM 3160 C CA  . CYS A 1 556 ? 121.291 152.952 110.253 1.00 74.98  ? 530 CYS A CA  1 
ATOM 3161 C C   . CYS A 1 556 ? 120.721 152.237 111.469 1.00 74.98  ? 530 CYS A C   1 
ATOM 3162 O O   . CYS A 1 556 ? 121.342 151.292 111.953 1.00 74.98  ? 530 CYS A O   1 
ATOM 3163 C CB  . CYS A 1 556 ? 122.684 153.519 110.561 1.00 74.98  ? 530 CYS A CB  1 
ATOM 3164 S SG  . CYS A 1 556 ? 122.827 155.015 111.530 1.00 74.98  ? 530 CYS A SG  1 
ATOM 3165 N N   . THR A 1 557 ? 119.527 152.605 111.934 1.00 73.57  ? 531 THR A N   1 
ATOM 3166 C CA  . THR A 1 557 ? 118.793 151.691 112.806 1.00 73.57  ? 531 THR A CA  1 
ATOM 3167 C C   . THR A 1 557 ? 118.346 150.461 112.020 1.00 73.57  ? 531 THR A C   1 
ATOM 3168 O O   . THR A 1 557 ? 118.346 149.337 112.544 1.00 73.57  ? 531 THR A O   1 
ATOM 3169 C CB  . THR A 1 557 ? 117.603 152.412 113.444 1.00 73.57  ? 531 THR A CB  1 
ATOM 3170 O OG1 . THR A 1 557 ? 118.066 153.604 114.090 1.00 73.57  ? 531 THR A OG1 1 
ATOM 3171 C CG2 . THR A 1 557 ? 116.926 151.538 114.489 1.00 73.57  ? 531 THR A CG2 1 
ATOM 3172 N N   . ARG A 1 558 ? 118.003 150.657 110.742 1.00 70.90  ? 532 ARG A N   1 
ATOM 3173 C CA  . ARG A 1 558 ? 117.775 149.529 109.843 1.00 70.90  ? 532 ARG A CA  1 
ATOM 3174 C C   . ARG A 1 558 ? 119.042 148.691 109.679 1.00 70.90  ? 532 ARG A C   1 
ATOM 3175 O O   . ARG A 1 558 ? 118.981 147.453 109.661 1.00 70.90  ? 532 ARG A O   1 
ATOM 3176 C CB  . ARG A 1 558 ? 117.273 150.048 108.493 1.00 70.90  ? 532 ARG A CB  1 
ATOM 3177 C CG  . ARG A 1 558 ? 117.400 149.086 107.326 1.00 70.90  ? 532 ARG A CG  1 
ATOM 3178 C CD  . ARG A 1 558 ? 116.436 149.460 106.213 1.00 70.90  ? 532 ARG A CD  1 
ATOM 3179 N NE  . ARG A 1 558 ? 115.082 149.662 106.716 1.00 70.90  ? 532 ARG A NE  1 
ATOM 3180 C CZ  . ARG A 1 558 ? 114.068 148.837 106.494 1.00 70.90  ? 532 ARG A CZ  1 
ATOM 3181 N NH1 . ARG A 1 558 ? 114.217 147.739 105.772 1.00 70.90  ? 532 ARG A NH1 1 
ATOM 3182 N NH2 . ARG A 1 558 ? 112.876 149.121 107.010 1.00 70.90  ? 532 ARG A NH2 1 
ATOM 3183 N N   . LYS A 1 559 ? 120.205 149.351 109.607 1.00 66.09  ? 533 LYS A N   1 
ATOM 3184 C CA  . LYS A 1 559 ? 121.476 148.633 109.555 1.00 66.09  ? 533 LYS A CA  1 
ATOM 3185 C C   . LYS A 1 559 ? 121.750 147.890 110.858 1.00 66.09  ? 533 LYS A C   1 
ATOM 3186 O O   . LYS A 1 559 ? 122.368 146.822 110.850 1.00 66.09  ? 533 LYS A O   1 
ATOM 3187 C CB  . LYS A 1 559 ? 122.617 149.601 109.251 1.00 66.09  ? 533 LYS A CB  1 
ATOM 3188 C CG  . LYS A 1 559 ? 122.489 150.334 107.929 1.00 66.09  ? 533 LYS A CG  1 
ATOM 3189 C CD  . LYS A 1 559 ? 123.669 151.267 107.707 1.00 66.09  ? 533 LYS A CD  1 
ATOM 3190 C CE  . LYS A 1 559 ? 123.785 151.678 106.253 1.00 66.09  ? 533 LYS A CE  1 
ATOM 3191 N NZ  . LYS A 1 559 ? 124.469 150.639 105.442 1.00 66.09  ? 533 LYS A NZ  1 
ATOM 3192 N N   . PHE A 1 560 ? 121.294 148.441 111.985 1.00 61.66  ? 534 PHE A N   1 
ATOM 3193 C CA  . PHE A 1 560 ? 121.414 147.752 113.267 1.00 61.66  ? 534 PHE A CA  1 
ATOM 3194 C C   . PHE A 1 560 ? 120.560 146.491 113.300 1.00 61.66  ? 534 PHE A C   1 
ATOM 3195 O O   . PHE A 1 560 ? 120.969 145.466 113.862 1.00 61.66  ? 534 PHE A O   1 
ATOM 3196 C CB  . PHE A 1 560 ? 121.014 148.695 114.401 1.00 61.66  ? 534 PHE A CB  1 
ATOM 3197 C CG  . PHE A 1 560 ? 120.716 147.999 115.695 1.00 61.66  ? 534 PHE A CG  1 
ATOM 3198 C CD1 . PHE A 1 560 ? 121.733 147.403 116.423 1.00 61.66  ? 534 PHE A CD1 1 
ATOM 3199 C CD2 . PHE A 1 560 ? 119.421 147.936 116.182 1.00 61.66  ? 534 PHE A CD2 1 
ATOM 3200 C CE1 . PHE A 1 560 ? 121.466 146.765 117.616 1.00 61.66  ? 534 PHE A CE1 1 
ATOM 3201 C CE2 . PHE A 1 560 ? 119.144 147.291 117.372 1.00 61.66  ? 534 PHE A CE2 1 
ATOM 3202 C CZ  . PHE A 1 560 ? 120.168 146.700 118.088 1.00 61.66  ? 534 PHE A CZ  1 
ATOM 3203 N N   . TYR A 1 561 ? 119.359 146.558 112.722 1.00 62.10  ? 535 TYR A N   1 
ATOM 3204 C CA  . TYR A 1 561 ? 118.510 145.369 112.651 1.00 62.10  ? 535 TYR A CA  1 
ATOM 3205 C C   . TYR A 1 561 ? 119.112 144.315 111.728 1.00 62.10  ? 535 TYR A C   1 
ATOM 3206 O O   . TYR A 1 561 ? 119.056 143.110 112.023 1.00 62.10  ? 535 TYR A O   1 
ATOM 3207 C CB  . TYR A 1 561 ? 117.101 145.752 112.202 1.00 62.10  ? 535 TYR A CB  1 
ATOM 3208 C CG  . TYR A 1 561 ? 116.267 146.337 113.318 1.00 62.10  ? 535 TYR A CG  1 
ATOM 3209 C CD1 . TYR A 1 561 ? 115.991 145.599 114.461 1.00 62.10  ? 535 TYR A CD1 1 
ATOM 3210 C CD2 . TYR A 1 561 ? 115.753 147.622 113.226 1.00 62.10  ? 535 TYR A CD2 1 
ATOM 3211 C CE1 . TYR A 1 561 ? 115.233 146.129 115.487 1.00 62.10  ? 535 TYR A CE1 1 
ATOM 3212 C CE2 . TYR A 1 561 ? 114.995 148.162 114.246 1.00 62.10  ? 535 TYR A CE2 1 
ATOM 3213 C CZ  . TYR A 1 561 ? 114.737 147.410 115.373 1.00 62.10  ? 535 TYR A CZ  1 
ATOM 3214 O OH  . TYR A 1 561 ? 113.978 147.944 116.388 1.00 62.10  ? 535 TYR A OH  1 
ATOM 3215 N N   . PHE A 1 562 ? 119.720 144.757 110.619 1.00 59.38  ? 536 PHE A N   1 
ATOM 3216 C CA  . PHE A 1 562 ? 120.507 143.855 109.780 1.00 59.38  ? 536 PHE A CA  1 
ATOM 3217 C C   . PHE A 1 562 ? 121.660 143.234 110.562 1.00 59.38  ? 536 PHE A C   1 
ATOM 3218 O O   . PHE A 1 562 ? 121.935 142.035 110.428 1.00 59.38  ? 536 PHE A O   1 
ATOM 3219 C CB  . PHE A 1 562 ? 121.050 144.599 108.559 1.00 59.38  ? 536 PHE A CB  1 
ATOM 3220 C CG  . PHE A 1 562 ? 120.105 144.635 107.395 1.00 59.38  ? 536 PHE A CG  1 
ATOM 3221 C CD1 . PHE A 1 562 ? 119.823 143.480 106.682 1.00 59.38  ? 536 PHE A CD1 1 
ATOM 3222 C CD2 . PHE A 1 562 ? 119.525 145.825 106.991 1.00 59.38  ? 536 PHE A CD2 1 
ATOM 3223 C CE1 . PHE A 1 562 ? 118.959 143.507 105.602 1.00 59.38  ? 536 PHE A CE1 1 
ATOM 3224 C CE2 . PHE A 1 562 ? 118.661 145.862 105.911 1.00 59.38  ? 536 PHE A CE2 1 
ATOM 3225 C CZ  . PHE A 1 562 ? 118.379 144.701 105.215 1.00 59.38  ? 536 PHE A CZ  1 
ATOM 3226 N N   . PHE A 1 563 ? 122.318 144.036 111.405 1.00 54.53  ? 537 PHE A N   1 
ATOM 3227 C CA  . PHE A 1 563 ? 123.452 143.566 112.194 1.00 54.53  ? 537 PHE A CA  1 
ATOM 3228 C C   . PHE A 1 563 ? 123.038 142.490 113.190 1.00 54.53  ? 537 PHE A C   1 
ATOM 3229 O O   . PHE A 1 563 ? 123.738 141.486 113.345 1.00 54.53  ? 537 PHE A O   1 
ATOM 3230 C CB  . PHE A 1 563 ? 124.102 144.744 112.924 1.00 54.53  ? 537 PHE A CB  1 
ATOM 3231 C CG  . PHE A 1 563 ? 125.333 144.375 113.705 1.00 54.53  ? 537 PHE A CG  1 
ATOM 3232 C CD1 . PHE A 1 563 ? 126.551 144.254 113.066 1.00 54.53  ? 537 PHE A CD1 1 
ATOM 3233 C CD2 . PHE A 1 563 ? 125.276 144.155 115.073 1.00 54.53  ? 537 PHE A CD2 1 
ATOM 3234 C CE1 . PHE A 1 563 ? 127.686 143.910 113.767 1.00 54.53  ? 537 PHE A CE1 1 
ATOM 3235 C CE2 . PHE A 1 563 ? 126.411 143.809 115.780 1.00 54.53  ? 537 PHE A CE2 1 
ATOM 3236 C CZ  . PHE A 1 563 ? 127.616 143.690 115.126 1.00 54.53  ? 537 PHE A CZ  1 
ATOM 3237 N N   . VAL A 1 564 ? 121.907 142.677 113.874 1.00 54.16  ? 538 VAL A N   1 
ATOM 3238 C CA  . VAL A 1 564 ? 121.507 141.666 114.853 1.00 54.16  ? 538 VAL A CA  1 
ATOM 3239 C C   . VAL A 1 564 ? 120.952 140.424 114.165 1.00 54.16  ? 538 VAL A C   1 
ATOM 3240 O O   . VAL A 1 564 ? 121.057 139.314 114.709 1.00 54.16  ? 538 VAL A O   1 
ATOM 3241 C CB  . VAL A 1 564 ? 120.525 142.234 115.895 1.00 54.16  ? 538 VAL A CB  1 
ATOM 3242 C CG1 . VAL A 1 564 ? 121.185 143.342 116.675 1.00 54.16  ? 538 VAL A CG1 1 
ATOM 3243 C CG2 . VAL A 1 564 ? 119.253 142.732 115.252 1.00 54.16  ? 538 VAL A CG2 1 
ATOM 3244 N N   . ALA A 1 565 ? 120.402 140.568 112.951 1.00 52.44  ? 539 ALA A N   1 
ATOM 3245 C CA  . ALA A 1 565 ? 120.059 139.387 112.159 1.00 52.44  ? 539 ALA A CA  1 
ATOM 3246 C C   . ALA A 1 565 ? 121.301 138.582 111.791 1.00 52.44  ? 539 ALA A C   1 
ATOM 3247 O O   . ALA A 1 565 ? 121.306 137.346 111.897 1.00 52.44  ? 539 ALA A O   1 
ATOM 3248 C CB  . ALA A 1 565 ? 119.303 139.802 110.900 1.00 52.44  ? 539 ALA A CB  1 
ATOM 3249 N N   . ILE A 1 566 ? 122.368 139.268 111.371 1.00 49.95  ? 540 ILE A N   1 
ATOM 3250 C CA  . ILE A 1 566 ? 123.594 138.562 111.007 1.00 49.95  ? 540 ILE A CA  1 
ATOM 3251 C C   . ILE A 1 566 ? 124.279 137.982 112.251 1.00 49.95  ? 540 ILE A C   1 
ATOM 3252 O O   . ILE A 1 566 ? 124.872 136.904 112.179 1.00 49.95  ? 540 ILE A O   1 
ATOM 3253 C CB  . ILE A 1 566 ? 124.521 139.481 110.181 1.00 49.95  ? 540 ILE A CB  1 
ATOM 3254 C CG1 . ILE A 1 566 ? 123.823 139.930 108.890 1.00 49.95  ? 540 ILE A CG1 1 
ATOM 3255 C CG2 . ILE A 1 566 ? 125.801 138.765 109.782 1.00 49.95  ? 540 ILE A CG2 1 
ATOM 3256 C CD1 . ILE A 1 566 ? 123.794 138.918 107.750 1.00 49.95  ? 540 ILE A CD1 1 
ATOM 3257 N N   . GLN A 1 567 ? 124.175 138.646 113.412 1.00 48.88  ? 541 GLN A N   1 
ATOM 3258 C CA  . GLN A 1 567 ? 124.626 138.032 114.667 1.00 48.88  ? 541 GLN A CA  1 
ATOM 3259 C C   . GLN A 1 567 ? 123.868 136.757 115.003 1.00 48.88  ? 541 GLN A C   1 
ATOM 3260 O O   . GLN A 1 567 ? 124.480 135.779 115.443 1.00 48.88  ? 541 GLN A O   1 
ATOM 3261 C CB  . GLN A 1 567 ? 124.516 139.004 115.845 1.00 48.88  ? 541 GLN A CB  1 
ATOM 3262 C CG  . GLN A 1 567 ? 125.425 140.204 115.821 1.00 48.88  ? 541 GLN A CG  1 
ATOM 3263 C CD  . GLN A 1 567 ? 126.885 139.794 115.884 1.00 48.88  ? 541 GLN A CD  1 
ATOM 3264 O OE1 . GLN A 1 567 ? 127.626 139.913 114.914 1.00 48.88  ? 541 GLN A OE1 1 
ATOM 3265 N NE2 . GLN A 1 567 ? 127.299 139.294 117.040 1.00 48.88  ? 541 GLN A NE2 1 
ATOM 3266 N N   . VAL A 1 568 ? 122.542 136.749 114.817 1.00 48.51  ? 542 VAL A N   1 
ATOM 3267 C CA  . VAL A 1 568 ? 121.754 135.545 115.095 1.00 48.51  ? 542 VAL A CA  1 
ATOM 3268 C C   . VAL A 1 568 ? 122.171 134.405 114.170 1.00 48.51  ? 542 VAL A C   1 
ATOM 3269 O O   . VAL A 1 568 ? 122.421 133.273 114.619 1.00 48.51  ? 542 VAL A O   1 
ATOM 3270 C CB  . VAL A 1 568 ? 120.251 135.865 114.978 1.00 48.51  ? 542 VAL A CB  1 
ATOM 3271 C CG1 . VAL A 1 568 ? 119.430 134.606 114.749 1.00 48.51  ? 542 VAL A CG1 1 
ATOM 3272 C CG2 . VAL A 1 568 ? 119.771 136.586 116.222 1.00 48.51  ? 542 VAL A CG2 1 
ATOM 3273 N N   . LEU A 1 569 ? 122.324 134.712 112.880 1.00 45.37  ? 543 LEU A N   1 
ATOM 3274 C CA  . LEU A 1 569 ? 122.726 133.711 111.895 1.00 45.37  ? 543 LEU A CA  1 
ATOM 3275 C C   . LEU A 1 569 ? 124.155 133.220 112.142 1.00 45.37  ? 543 LEU A C   1 
ATOM 3276 O O   . LEU A 1 569 ? 124.444 132.020 112.024 1.00 45.37  ? 543 LEU A O   1 
ATOM 3277 C CB  . LEU A 1 569 ? 122.571 134.325 110.506 1.00 45.37  ? 543 LEU A CB  1 
ATOM 3278 C CG  . LEU A 1 569 ? 122.771 133.584 109.197 1.00 45.37  ? 543 LEU A CG  1 
ATOM 3279 C CD1 . LEU A 1 569 ? 121.779 132.445 109.079 1.00 45.37  ? 543 LEU A CD1 1 
ATOM 3280 C CD2 . LEU A 1 569 ? 122.557 134.587 108.086 1.00 45.37  ? 543 LEU A CD2 1 
ATOM 3281 N N   . ASN A 1 570 ? 125.042 134.133 112.541 1.00 44.29  ? 544 ASN A N   1 
ATOM 3282 C CA  . ASN A 1 570 ? 126.442 133.815 112.797 1.00 44.29  ? 544 ASN A CA  1 
ATOM 3283 C C   . ASN A 1 570 ? 126.574 132.930 114.032 1.00 44.29  ? 544 ASN A C   1 
ATOM 3284 O O   . ASN A 1 570 ? 127.345 131.966 114.025 1.00 44.29  ? 544 ASN A O   1 
ATOM 3285 C CB  . ASN A 1 570 ? 127.208 135.137 112.963 1.00 44.29  ? 544 ASN A CB  1 
ATOM 3286 C CG  . ASN A 1 570 ? 128.723 134.984 113.167 1.00 44.29  ? 544 ASN A CG  1 
ATOM 3287 O OD1 . ASN A 1 570 ? 129.284 133.899 113.293 1.00 44.29  ? 544 ASN A OD1 1 
ATOM 3288 N ND2 . ASN A 1 570 ? 129.385 136.125 113.232 1.00 44.29  ? 544 ASN A ND2 1 
ATOM 3289 N N   . LEU A 1 571 ? 125.838 133.243 115.105 1.00 43.27  ? 545 LEU A N   1 
ATOM 3290 C CA  . LEU A 1 571 ? 125.901 132.413 116.305 1.00 43.27  ? 545 LEU A CA  1 
ATOM 3291 C C   . LEU A 1 571 ? 125.277 131.046 116.069 1.00 43.27  ? 545 LEU A C   1 
ATOM 3292 O O   . LEU A 1 571 ? 125.734 130.049 116.643 1.00 43.27  ? 545 LEU A O   1 
ATOM 3293 C CB  . LEU A 1 571 ? 125.235 133.111 117.487 1.00 43.27  ? 545 LEU A CB  1 
ATOM 3294 C CG  . LEU A 1 571 ? 125.932 134.366 118.012 1.00 43.27  ? 545 LEU A CG  1 
ATOM 3295 C CD1 . LEU A 1 571 ? 125.097 135.032 119.089 1.00 43.27  ? 545 LEU A CD1 1 
ATOM 3296 C CD2 . LEU A 1 571 ? 127.319 134.036 118.535 1.00 43.27  ? 545 LEU A CD2 1 
ATOM 3297 N N   . PHE A 1 572 ? 124.252 130.973 115.210 1.00 41.70  ? 546 PHE A N   1 
ATOM 3298 C CA  . PHE A 1 572 ? 123.713 129.671 114.822 1.00 41.70  ? 546 PHE A CA  1 
ATOM 3299 C C   . PHE A 1 572 ? 124.747 128.836 114.076 1.00 41.70  ? 546 PHE A C   1 
ATOM 3300 O O   . PHE A 1 572 ? 124.902 127.639 114.348 1.00 41.70  ? 546 PHE A O   1 
ATOM 3301 C CB  . PHE A 1 572 ? 122.462 129.851 113.966 1.00 41.70  ? 546 PHE A CB  1 
ATOM 3302 C CG  . PHE A 1 572 ? 121.906 128.562 113.432 1.00 41.70  ? 546 PHE A CG  1 
ATOM 3303 C CD1 . PHE A 1 572 ? 121.243 127.681 114.271 1.00 41.70  ? 546 PHE A CD1 1 
ATOM 3304 C CD2 . PHE A 1 572 ? 122.040 128.234 112.094 1.00 41.70  ? 546 PHE A CD2 1 
ATOM 3305 C CE1 . PHE A 1 572 ? 120.730 126.498 113.786 1.00 41.70  ? 546 PHE A CE1 1 
ATOM 3306 C CE2 . PHE A 1 572 ? 121.530 127.051 111.605 1.00 41.70  ? 546 PHE A CE2 1 
ATOM 3307 C CZ  . PHE A 1 572 ? 120.873 126.183 112.454 1.00 41.70  ? 546 PHE A CZ  1 
ATOM 3308 N N   . PHE A 1 573 ? 125.486 129.456 113.152 1.00 41.30  ? 547 PHE A N   1 
ATOM 3309 C CA  . PHE A 1 573 ? 126.481 128.698 112.396 1.00 41.30  ? 547 PHE A CA  1 
ATOM 3310 C C   . PHE A 1 573 ? 127.697 128.350 113.249 1.00 41.30  ? 547 PHE A C   1 
ATOM 3311 O O   . PHE A 1 573 ? 128.322 127.304 113.045 1.00 41.30  ? 547 PHE A O   1 
ATOM 3312 C CB  . PHE A 1 573 ? 126.895 129.470 111.147 1.00 41.30  ? 547 PHE A CB  1 
ATOM 3313 C CG  . PHE A 1 573 ? 126.056 129.152 109.950 1.00 41.30  ? 547 PHE A CG  1 
ATOM 3314 C CD1 . PHE A 1 573 ? 126.276 127.993 109.228 1.00 41.30  ? 547 PHE A CD1 1 
ATOM 3315 C CD2 . PHE A 1 573 ? 125.030 129.994 109.564 1.00 41.30  ? 547 PHE A CD2 1 
ATOM 3316 C CE1 . PHE A 1 573 ? 125.496 127.688 108.134 1.00 41.30  ? 547 PHE A CE1 1 
ATOM 3317 C CE2 . PHE A 1 573 ? 124.247 129.696 108.473 1.00 41.30  ? 547 PHE A CE2 1 
ATOM 3318 C CZ  . PHE A 1 573 ? 124.481 128.543 107.756 1.00 41.30  ? 547 PHE A CZ  1 
ATOM 3319 N N   . SER A 1 574 ? 128.045 129.204 114.213 1.00 41.30  ? 548 SER A N   1 
ATOM 3320 C CA  . SER A 1 574 ? 129.187 128.913 115.073 1.00 41.30  ? 548 SER A CA  1 
ATOM 3321 C C   . SER A 1 574 ? 128.854 127.823 116.080 1.00 41.30  ? 548 SER A C   1 
ATOM 3322 O O   . SER A 1 574 ? 129.715 127.007 116.423 1.00 41.30  ? 548 SER A O   1 
ATOM 3323 C CB  . SER A 1 574 ? 129.646 130.177 115.795 1.00 41.30  ? 548 SER A CB  1 
ATOM 3324 O OG  . SER A 1 574 ? 128.663 130.628 116.703 1.00 41.30  ? 548 SER A OG  1 
ATOM 3325 N N   . ALA A 1 575 ? 127.615 127.799 116.578 1.00 41.76  ? 549 ALA A N   1 
ATOM 3326 C CA  . ALA A 1 575 ? 127.193 126.701 117.437 1.00 41.76  ? 549 ALA A CA  1 
ATOM 3327 C C   . ALA A 1 575 ? 126.927 125.430 116.649 1.00 41.76  ? 549 ALA A C   1 
ATOM 3328 O O   . ALA A 1 575 ? 126.910 124.347 117.239 1.00 41.76  ? 549 ALA A O   1 
ATOM 3329 C CB  . ALA A 1 575 ? 125.944 127.095 118.222 1.00 41.76  ? 549 ALA A CB  1 
ATOM 3330 N N   . LEU A 1 576 ? 126.720 125.539 115.332 1.00 40.78  ? 550 LEU A N   1 
ATOM 3331 C CA  . LEU A 1 576 ? 126.498 124.354 114.509 1.00 40.78  ? 550 LEU A CA  1 
ATOM 3332 C C   . LEU A 1 576 ? 127.745 123.483 114.410 1.00 40.78  ? 550 LEU A C   1 
ATOM 3333 O O   . LEU A 1 576 ? 127.639 122.281 114.147 1.00 40.78  ? 550 LEU A O   1 
ATOM 3334 C CB  . LEU A 1 576 ? 126.030 124.776 113.118 1.00 40.78  ? 550 LEU A CB  1 
ATOM 3335 C CG  . LEU A 1 576 ? 125.236 123.761 112.302 1.00 40.78  ? 550 LEU A CG  1 
ATOM 3336 C CD1 . LEU A 1 576 ? 123.842 123.613 112.863 1.00 40.78  ? 550 LEU A CD1 1 
ATOM 3337 C CD2 . LEU A 1 576 ? 125.176 124.188 110.853 1.00 40.78  ? 550 LEU A CD2 1 
ATOM 3338 N N   . GLY A 1 577 ? 128.927 124.059 114.616 1.00 41.31  ? 551 GLY A N   1 
ATOM 3339 C CA  . GLY A 1 577 ? 130.156 123.292 114.551 1.00 41.31  ? 551 GLY A CA  1 
ATOM 3340 C C   . GLY A 1 577 ? 130.878 123.144 115.876 1.00 41.31  ? 551 GLY A C   1 
ATOM 3341 O O   . GLY A 1 577 ? 132.101 122.989 115.899 1.00 41.31  ? 551 GLY A O   1 
ATOM 3342 N N   . GLY A 1 578 ? 130.140 123.205 116.985 1.00 38.12  ? 552 GLY A N   1 
ATOM 3343 C CA  . GLY A 1 578 ? 130.775 123.107 118.291 1.00 38.12  ? 552 GLY A CA  1 
ATOM 3344 C C   . GLY A 1 578 ? 131.236 121.703 118.638 1.00 38.12  ? 552 GLY A C   1 
ATOM 3345 O O   . GLY A 1 578 ? 132.298 121.520 119.238 1.00 38.12  ? 552 GLY A O   1 
ATOM 3346 N N   . THR A 1 579 ? 130.437 120.696 118.279 1.00 35.65  ? 553 THR A N   1 
ATOM 3347 C CA  . THR A 1 579 ? 130.754 119.299 118.561 1.00 35.65  ? 553 THR A CA  1 
ATOM 3348 C C   . THR A 1 579 ? 131.970 118.815 117.780 1.00 35.65  ? 553 THR A C   1 
ATOM 3349 O O   . THR A 1 579 ? 132.705 117.935 118.261 1.00 35.65  ? 553 THR A O   1 
ATOM 3350 C CB  . THR A 1 579 ? 129.530 118.446 118.223 1.00 35.65  ? 553 THR A CB  1 
ATOM 3351 O OG1 . THR A 1 579 ? 128.358 119.086 118.735 1.00 35.65  ? 553 THR A OG1 1 
ATOM 3352 C CG2 . THR A 1 579 ? 129.625 117.065 118.826 1.00 35.65  ? 553 THR A CG2 1 
ATOM 3353 N N   . SER A 1 580 ? 132.212 119.412 116.611 1.00 38.24  ? 554 SER A N   1 
ATOM 3354 C CA  . SER A 1 580 ? 133.175 118.879 115.659 1.00 38.24  ? 554 SER A CA  1 
ATOM 3355 C C   . SER A 1 580 ? 134.604 119.004 116.158 1.00 38.24  ? 554 SER A C   1 
ATOM 3356 O O   . SER A 1 580 ? 135.453 118.194 115.778 1.00 38.24  ? 554 SER A O   1 
ATOM 3357 C CB  . SER A 1 580 ? 133.017 119.593 114.323 1.00 38.24  ? 554 SER A CB  1 
ATOM 3358 O OG  . SER A 1 580 ? 131.737 119.356 113.768 1.00 38.24  ? 554 SER A OG  1 
ATOM 3359 N N   . HIS A 1 581 ? 134.879 119.988 117.021 1.00 35.56  ? 555 HIS A N   1 
ATOM 3360 C CA  . HIS A 1 581 ? 136.207 120.128 117.615 1.00 35.56  ? 555 HIS A CA  1 
ATOM 3361 C C   . HIS A 1 581 ? 136.559 118.917 118.466 1.00 35.56  ? 555 HIS A C   1 
ATOM 3362 O O   . HIS A 1 581 ? 137.622 118.314 118.292 1.00 35.56  ? 555 HIS A O   1 
ATOM 3363 C CB  . HIS A 1 581 ? 136.276 121.399 118.460 1.00 35.56  ? 555 HIS A CB  1 
ATOM 3364 C CG  . HIS A 1 581 ? 136.049 122.656 117.684 1.00 35.56  ? 555 HIS A CG  1 
ATOM 3365 N ND1 . HIS A 1 581 ? 135.661 123.835 118.281 1.00 35.56  ? 555 HIS A ND1 1 
ATOM 3366 C CD2 . HIS A 1 581 ? 136.162 122.922 116.362 1.00 35.56  ? 555 HIS A CD2 1 
ATOM 3367 C CE1 . HIS A 1 581 ? 135.540 124.773 117.359 1.00 35.56  ? 555 HIS A CE1 1 
ATOM 3368 N NE2 . HIS A 1 581 ? 135.840 124.245 116.186 1.00 35.56  ? 555 HIS A NE2 1 
ATOM 3369 N N   . VAL A 1 582 ? 135.650 118.521 119.359 1.00 35.20  ? 556 VAL A N   1 
ATOM 3370 C CA  . VAL A 1 582 ? 135.893 117.383 120.239 1.00 35.20  ? 556 VAL A CA  1 
ATOM 3371 C C   . VAL A 1 582 ? 135.885 116.077 119.453 1.00 35.20  ? 556 VAL A C   1 
ATOM 3372 O O   . VAL A 1 582 ? 136.709 115.188 119.706 1.00 35.20  ? 556 VAL A O   1 
ATOM 3373 C CB  . VAL A 1 582 ? 134.864 117.381 121.382 1.00 35.20  ? 556 VAL A CB  1 
ATOM 3374 C CG1 . VAL A 1 582 ? 134.990 116.143 122.252 1.00 35.20  ? 556 VAL A CG1 1 
ATOM 3375 C CG2 . VAL A 1 582 ? 135.008 118.638 122.221 1.00 35.20  ? 556 VAL A CG2 1 
ATOM 3376 N N   . MET A 1 583 ? 134.980 115.950 118.471 1.00 33.96  ? 557 MET A N   1 
ATOM 3377 C CA  . MET A 1 583 ? 134.940 114.739 117.645 1.00 33.96  ? 557 MET A CA  1 
ATOM 3378 C C   . MET A 1 583 ? 136.227 114.557 116.842 1.00 33.96  ? 557 MET A C   1 
ATOM 3379 O O   . MET A 1 583 ? 136.812 113.465 116.827 1.00 33.96  ? 557 MET A O   1 
ATOM 3380 C CB  . MET A 1 583 ? 133.728 114.768 116.713 1.00 33.96  ? 557 MET A CB  1 
ATOM 3381 C CG  . MET A 1 583 ? 132.389 114.803 117.419 1.00 33.96  ? 557 MET A CG  1 
ATOM 3382 S SD  . MET A 1 583 ? 132.070 113.294 118.350 1.00 33.96  ? 557 MET A SD  1 
ATOM 3383 C CE  . MET A 1 583 ? 131.963 113.927 120.019 1.00 33.96  ? 557 MET A CE  1 
ATOM 3384 N N   . LEU A 1 584 ? 136.708 115.632 116.212 1.00 35.41  ? 558 LEU A N   1 
ATOM 3385 C CA  . LEU A 1 584 ? 137.961 115.570 115.473 1.00 35.41  ? 558 LEU A CA  1 
ATOM 3386 C C   . LEU A 1 584 ? 139.142 115.309 116.392 1.00 35.41  ? 558 LEU A C   1 
ATOM 3387 O O   . LEU A 1 584 ? 140.025 114.515 116.059 1.00 35.41  ? 558 LEU A O   1 
ATOM 3388 C CB  . LEU A 1 584 ? 138.179 116.869 114.708 1.00 35.41  ? 558 LEU A CB  1 
ATOM 3389 C CG  . LEU A 1 584 ? 137.521 116.986 113.344 1.00 35.41  ? 558 LEU A CG  1 
ATOM 3390 C CD1 . LEU A 1 584 ? 137.374 118.442 112.966 1.00 35.41  ? 558 LEU A CD1 1 
ATOM 3391 C CD2 . LEU A 1 584 ? 138.360 116.245 112.332 1.00 35.41  ? 558 LEU A CD2 1 
ATOM 3392 N N   . ILE A 1 585 ? 139.166 115.942 117.564 1.00 32.91  ? 559 ILE A N   1 
ATOM 3393 C CA  . ILE A 1 585 ? 140.368 115.867 118.378 1.00 32.91  ? 559 ILE A CA  1 
ATOM 3394 C C   . ILE A 1 585 ? 140.396 114.545 119.140 1.00 32.91  ? 559 ILE A C   1 
ATOM 3395 O O   . ILE A 1 585 ? 141.441 114.133 119.657 1.00 32.91  ? 559 ILE A O   1 
ATOM 3396 C CB  . ILE A 1 585 ? 140.426 117.101 119.292 1.00 32.91  ? 559 ILE A CB  1 
ATOM 3397 C CG1 . ILE A 1 585 ? 141.808 117.307 119.853 1.00 32.91  ? 559 ILE A CG1 1 
ATOM 3398 C CG2 . ILE A 1 585 ? 139.569 116.900 120.511 1.00 32.91  ? 559 ILE A CG2 1 
ATOM 3399 C CD1 . ILE A 1 585 ? 141.948 118.655 120.413 1.00 32.91  ? 559 ILE A CD1 1 
ATOM 3400 N N   . VAL A 1 586 ? 139.263 113.844 119.201 1.00 35.16  ? 560 VAL A N   1 
ATOM 3401 C CA  . VAL A 1 586 ? 139.288 112.451 119.624 1.00 35.16  ? 560 VAL A CA  1 
ATOM 3402 C C   . VAL A 1 586 ? 139.793 111.563 118.494 1.00 35.16  ? 560 VAL A C   1 
ATOM 3403 O O   . VAL A 1 586 ? 140.695 110.740 118.693 1.00 35.16  ? 560 VAL A O   1 
ATOM 3404 C CB  . VAL A 1 586 ? 137.893 112.016 120.102 1.00 35.16  ? 560 VAL A CB  1 
ATOM 3405 C CG1 . VAL A 1 586 ? 137.771 110.512 120.042 1.00 35.16  ? 560 VAL A CG1 1 
ATOM 3406 C CG2 . VAL A 1 586 ? 137.635 112.517 121.511 1.00 35.16  ? 560 VAL A CG2 1 
ATOM 3407 N N   . LYS A 1 587 ? 139.243 111.730 117.285 1.00 35.67  ? 561 LYS A N   1 
ATOM 3408 C CA  . LYS A 1 587 ? 139.538 110.789 116.208 1.00 35.67  ? 561 LYS A CA  1 
ATOM 3409 C C   . LYS A 1 587 ? 140.945 110.951 115.643 1.00 35.67  ? 561 LYS A C   1 
ATOM 3410 O O   . LYS A 1 587 ? 141.451 110.035 114.987 1.00 35.67  ? 561 LYS A O   1 
ATOM 3411 C CB  . LYS A 1 587 ? 138.503 110.933 115.095 1.00 35.67  ? 561 LYS A CB  1 
ATOM 3412 C CG  . LYS A 1 587 ? 137.108 110.523 115.510 1.00 35.67  ? 561 LYS A CG  1 
ATOM 3413 C CD  . LYS A 1 587 ? 136.130 110.676 114.372 1.00 35.67  ? 561 LYS A CD  1 
ATOM 3414 C CE  . LYS A 1 587 ? 134.762 110.178 114.779 1.00 35.67  ? 561 LYS A CE  1 
ATOM 3415 N NZ  . LYS A 1 587 ? 134.174 111.043 115.835 1.00 35.67  ? 561 LYS A NZ  1 
ATOM 3416 N N   . ILE A 1 588 ? 141.586 112.092 115.883 1.00 35.79  ? 562 ILE A N   1 
ATOM 3417 C CA  . ILE A 1 588 ? 142.937 112.310 115.377 1.00 35.79  ? 562 ILE A CA  1 
ATOM 3418 C C   . ILE A 1 588 ? 143.956 111.535 116.208 1.00 35.79  ? 562 ILE A C   1 
ATOM 3419 O O   . ILE A 1 588 ? 144.808 110.821 115.668 1.00 35.79  ? 562 ILE A O   1 
ATOM 3420 C CB  . ILE A 1 588 ? 143.242 113.819 115.341 1.00 35.79  ? 562 ILE A CB  1 
ATOM 3421 C CG1 . ILE A 1 588 ? 142.629 114.455 114.095 1.00 35.79  ? 562 ILE A CG1 1 
ATOM 3422 C CG2 . ILE A 1 588 ? 144.726 114.090 115.352 1.00 35.79  ? 562 ILE A CG2 1 
ATOM 3423 C CD1 . ILE A 1 588 ? 142.567 115.961 114.163 1.00 35.79  ? 562 ILE A CD1 1 
ATOM 3424 N N   . VAL A 1 589 ? 143.870 111.646 117.532 1.00 35.11  ? 563 VAL A N   1 
ATOM 3425 C CA  . VAL A 1 589 ? 144.874 111.096 118.437 1.00 35.11  ? 563 VAL A CA  1 
ATOM 3426 C C   . VAL A 1 589 ? 144.644 109.614 118.696 1.00 35.11  ? 563 VAL A C   1 
ATOM 3427 O O   . VAL A 1 589 ? 143.632 109.045 118.273 1.00 35.11  ? 563 VAL A O   1 
ATOM 3428 C CB  . VAL A 1 589 ? 144.899 111.873 119.760 1.00 35.11  ? 563 VAL A CB  1 
ATOM 3429 C CG1 . VAL A 1 589 ? 145.134 113.326 119.482 1.00 35.11  ? 563 VAL A CG1 1 
ATOM 3430 C CG2 . VAL A 1 589 ? 143.605 111.674 120.504 1.00 35.11  ? 563 VAL A CG2 1 
ATOM 3431 N N   . GLN A 1 590 ? 145.607 108.984 119.367 1.00 42.10  ? 564 GLN A N   1 
ATOM 3432 C CA  . GLN A 1 590 ? 145.523 107.583 119.743 1.00 42.10  ? 564 GLN A CA  1 
ATOM 3433 C C   . GLN A 1 590 ? 144.381 107.363 120.738 1.00 42.10  ? 564 GLN A C   1 
ATOM 3434 O O   . GLN A 1 590 ? 144.037 108.268 121.501 1.00 42.10  ? 564 GLN A O   1 
ATOM 3435 C CB  . GLN A 1 590 ? 146.858 107.135 120.336 1.00 42.10  ? 564 GLN A CB  1 
ATOM 3436 C CG  . GLN A 1 590 ? 147.892 106.770 119.285 1.00 42.10  ? 564 GLN A CG  1 
ATOM 3437 C CD  . GLN A 1 590 ? 149.303 106.732 119.836 1.00 42.10  ? 564 GLN A CD  1 
ATOM 3438 O OE1 . GLN A 1 590 ? 149.666 107.530 120.699 1.00 42.10  ? 564 GLN A OE1 1 
ATOM 3439 N NE2 . GLN A 1 590 ? 150.109 105.805 119.334 1.00 42.10  ? 564 GLN A NE2 1 
ATOM 3440 N N   . PRO A 1 591 ? 143.748 106.179 120.713 1.00 37.62  ? 565 PRO A N   1 
ATOM 3441 C CA  . PRO A 1 591 ? 142.554 105.962 121.552 1.00 37.62  ? 565 PRO A CA  1 
ATOM 3442 C C   . PRO A 1 591 ? 142.811 105.992 123.049 1.00 37.62  ? 565 PRO A C   1 
ATOM 3443 O O   . PRO A 1 591 ? 141.891 106.306 123.814 1.00 37.62  ? 565 PRO A O   1 
ATOM 3444 C CB  . PRO A 1 591 ? 142.061 104.580 121.104 1.00 37.62  ? 565 PRO A CB  1 
ATOM 3445 C CG  . PRO A 1 591 ? 142.624 104.396 119.752 1.00 37.62  ? 565 PRO A CG  1 
ATOM 3446 C CD  . PRO A 1 591 ? 143.955 105.064 119.774 1.00 37.62  ? 565 PRO A CD  1 
ATOM 3447 N N   . GLU A 1 592 ? 144.023 105.676 123.497 1.00 40.06  ? 566 GLU A N   1 
ATOM 3448 C CA  . GLU A 1 592 ? 144.333 105.773 124.916 1.00 40.06  ? 566 GLU A CA  1 
ATOM 3449 C C   . GLU A 1 592 ? 144.835 107.153 125.317 1.00 40.06  ? 566 GLU A C   1 
ATOM 3450 O O   . GLU A 1 592 ? 145.178 107.353 126.486 1.00 40.06  ? 566 GLU A O   1 
ATOM 3451 C CB  . GLU A 1 592 ? 145.351 104.699 125.308 1.00 40.06  ? 566 GLU A CB  1 
ATOM 3452 C CG  . GLU A 1 592 ? 146.708 104.862 124.667 1.00 40.06  ? 566 GLU A CG  1 
ATOM 3453 C CD  . GLU A 1 592 ? 147.664 103.746 125.029 1.00 40.06  ? 566 GLU A CD  1 
ATOM 3454 O OE1 . GLU A 1 592 ? 147.255 102.826 125.769 1.00 40.06  ? 566 GLU A OE1 1 
ATOM 3455 O OE2 . GLU A 1 592 ? 148.829 103.790 124.578 1.00 40.06  ? 566 GLU A OE2 1 
ATOM 3456 N N   . LEU A 1 593 ? 144.882 108.103 124.382 1.00 35.79  ? 567 LEU A N   1 
ATOM 3457 C CA  . LEU A 1 593 ? 145.218 109.493 124.668 1.00 35.79  ? 567 LEU A CA  1 
ATOM 3458 C C   . LEU A 1 593 ? 144.049 110.437 124.431 1.00 35.79  ? 567 LEU A C   1 
ATOM 3459 O O   . LEU A 1 593 ? 144.272 111.619 124.158 1.00 35.79  ? 567 LEU A O   1 
ATOM 3460 C CB  . LEU A 1 593 ? 146.410 109.962 123.832 1.00 35.79  ? 567 LEU A CB  1 
ATOM 3461 C CG  . LEU A 1 593 ? 147.869 109.645 124.152 1.00 35.79  ? 567 LEU A CG  1 
ATOM 3462 C CD1 . LEU A 1 593 ? 148.190 110.362 125.430 1.00 35.79  ? 567 LEU A CD1 1 
ATOM 3463 C CD2 . LEU A 1 593 ? 148.221 108.177 124.248 1.00 35.79  ? 567 LEU A CD2 1 
ATOM 3464 N N   . LYS A 1 594 ? 142.815 109.939 124.516 1.00 33.24  ? 568 LYS A N   1 
ATOM 3465 C CA  . LYS A 1 594 ? 141.646 110.771 124.244 1.00 33.24  ? 568 LYS A CA  1 
ATOM 3466 C C   . LYS A 1 594 ? 141.474 111.858 125.295 1.00 33.24  ? 568 LYS A C   1 
ATOM 3467 O O   . LYS A 1 594 ? 141.090 112.987 124.972 1.00 33.24  ? 568 LYS A O   1 
ATOM 3468 C CB  . LYS A 1 594 ? 140.394 109.901 124.186 1.00 33.24  ? 568 LYS A CB  1 
ATOM 3469 C CG  . LYS A 1 594 ? 140.146 109.232 122.854 1.00 33.24  ? 568 LYS A CG  1 
ATOM 3470 C CD  . LYS A 1 594 ? 138.832 108.477 122.882 1.00 33.24  ? 568 LYS A CD  1 
ATOM 3471 C CE  . LYS A 1 594 ? 138.799 107.392 121.827 1.00 33.24  ? 568 LYS A CE  1 
ATOM 3472 N NZ  . LYS A 1 594 ? 138.289 106.103 122.350 1.00 33.24  ? 568 LYS A NZ  1 
ATOM 3473 N N   . SER A 1 595 ? 141.738 111.531 126.559 1.00 30.22  ? 569 SER A N   1 
ATOM 3474 C CA  . SER A 1 595 ? 141.514 112.487 127.637 1.00 30.22  ? 569 SER A CA  1 
ATOM 3475 C C   . SER A 1 595 ? 142.574 113.579 127.639 1.00 30.22  ? 569 SER A C   1 
ATOM 3476 O O   . SER A 1 595 ? 142.248 114.769 127.736 1.00 30.22  ? 569 SER A O   1 
ATOM 3477 C CB  . SER A 1 595 ? 141.488 111.756 128.975 1.00 30.22  ? 569 SER A CB  1 
ATOM 3478 O OG  . SER A 1 595 ? 141.747 112.646 130.041 1.00 30.22  ? 569 SER A OG  1 
ATOM 3479 N N   . LEU A 1 596 ? 143.848 113.187 127.516 1.00 30.23  ? 570 LEU A N   1 
ATOM 3480 C CA  . LEU A 1 596 ? 144.957 114.139 127.551 1.00 30.23  ? 570 LEU A CA  1 
ATOM 3481 C C   . LEU A 1 596 ? 144.898 115.103 126.376 1.00 30.23  ? 570 LEU A C   1 
ATOM 3482 O O   . LEU A 1 596 ? 145.135 116.306 126.543 1.00 30.23  ? 570 LEU A O   1 
ATOM 3483 C CB  . LEU A 1 596 ? 146.286 113.385 127.562 1.00 30.23  ? 570 LEU A CB  1 
ATOM 3484 C CG  . LEU A 1 596 ? 147.594 114.180 127.552 1.00 30.23  ? 570 LEU A CG  1 
ATOM 3485 C CD1 . LEU A 1 596 ? 147.602 115.261 128.609 1.00 30.23  ? 570 LEU A CD1 1 
ATOM 3486 C CD2 . LEU A 1 596 ? 148.766 113.248 127.758 1.00 30.23  ? 570 LEU A CD2 1 
ATOM 3487 N N   . ALA A 1 597 ? 144.547 114.598 125.191 1.00 29.07  ? 571 ALA A N   1 
ATOM 3488 C CA  . ALA A 1 597 ? 144.327 115.465 124.040 1.00 29.07  ? 571 ALA A CA  1 
ATOM 3489 C C   . ALA A 1 597 ? 143.137 116.387 124.259 1.00 29.07  ? 571 ALA A C   1 
ATOM 3490 O O   . ALA A 1 597 ? 143.107 117.507 123.739 1.00 29.07  ? 571 ALA A O   1 
ATOM 3491 C CB  . ALA A 1 597 ? 144.117 114.624 122.790 1.00 29.07  ? 571 ALA A CB  1 
ATOM 3492 N N   . LEU A 1 598 ? 142.148 115.938 125.028 1.00 28.82  ? 572 LEU A N   1 
ATOM 3493 C CA  . LEU A 1 598 ? 141.056 116.820 125.402 1.00 28.82  ? 572 LEU A CA  1 
ATOM 3494 C C   . LEU A 1 598 ? 141.410 117.708 126.583 1.00 28.82  ? 572 LEU A C   1 
ATOM 3495 O O   . LEU A 1 598 ? 140.694 118.678 126.846 1.00 28.82  ? 572 LEU A O   1 
ATOM 3496 C CB  . LEU A 1 598 ? 139.805 116.001 125.717 1.00 28.82  ? 572 LEU A CB  1 
ATOM 3497 C CG  . LEU A 1 598 ? 138.988 115.627 124.485 1.00 28.82  ? 572 LEU A CG  1 
ATOM 3498 C CD1 . LEU A 1 598 ? 138.066 114.466 124.775 1.00 28.82  ? 572 LEU A CD1 1 
ATOM 3499 C CD2 . LEU A 1 598 ? 138.212 116.835 124.014 1.00 28.82  ? 572 LEU A CD2 1 
ATOM 3500 N N   . GLY A 1 599 ? 142.498 117.409 127.289 1.00 30.33  ? 573 GLY A N   1 
ATOM 3501 C CA  . GLY A 1 599 ? 142.903 118.226 128.414 1.00 30.33  ? 573 GLY A CA  1 
ATOM 3502 C C   . GLY A 1 599 ? 143.797 119.372 127.996 1.00 30.33  ? 573 GLY A C   1 
ATOM 3503 O O   . GLY A 1 599 ? 143.498 120.536 128.288 1.00 30.33  ? 573 GLY A O   1 
ATOM 3504 N N   . PHE A 1 600 ? 144.879 119.035 127.283 1.00 31.66  ? 574 PHE A N   1 
ATOM 3505 C CA  . PHE A 1 600 ? 145.874 120.023 126.870 1.00 31.66  ? 574 PHE A CA  1 
ATOM 3506 C C   . PHE A 1 600 ? 145.277 121.070 125.943 1.00 31.66  ? 574 PHE A C   1 
ATOM 3507 O O   . PHE A 1 600 ? 145.594 122.260 126.059 1.00 31.66  ? 574 PHE A O   1 
ATOM 3508 C CB  . PHE A 1 600 ? 147.048 119.329 126.185 1.00 31.66  ? 574 PHE A CB  1 
ATOM 3509 C CG  . PHE A 1 600 ? 148.042 120.279 125.582 1.00 31.66  ? 574 PHE A CG  1 
ATOM 3510 C CD1 . PHE A 1 600 ? 148.688 121.216 126.367 1.00 31.66  ? 574 PHE A CD1 1 
ATOM 3511 C CD2 . PHE A 1 600 ? 148.322 120.238 124.228 1.00 31.66  ? 574 PHE A CD2 1 
ATOM 3512 C CE1 . PHE A 1 600 ? 149.596 122.090 125.813 1.00 31.66  ? 574 PHE A CE1 1 
ATOM 3513 C CE2 . PHE A 1 600 ? 149.230 121.111 123.669 1.00 31.66  ? 574 PHE A CE2 1 
ATOM 3514 C CZ  . PHE A 1 600 ? 149.867 122.036 124.461 1.00 31.66  ? 574 PHE A CZ  1 
ATOM 3515 N N   . HIS A 1 601 ? 144.408 120.640 125.024 1.00 33.72  ? 575 HIS A N   1 
ATOM 3516 C CA  . HIS A 1 601 ? 143.669 121.571 124.177 1.00 33.72  ? 575 HIS A CA  1 
ATOM 3517 C C   . HIS A 1 601 ? 142.797 122.494 125.011 1.00 33.72  ? 575 HIS A C   1 
ATOM 3518 O O   . HIS A 1 601 ? 142.758 123.707 124.771 1.00 33.72  ? 575 HIS A O   1 
ATOM 3519 C CB  . HIS A 1 601 ? 142.825 120.787 123.182 1.00 33.72  ? 575 HIS A CB  1 
ATOM 3520 C CG  . HIS A 1 601 ? 141.891 121.625 122.366 1.00 33.72  ? 575 HIS A CG  1 
ATOM 3521 N ND1 . HIS A 1 601 ? 140.526 121.614 122.554 1.00 33.72  ? 575 HIS A ND1 1 
ATOM 3522 C CD2 . HIS A 1 601 ? 142.122 122.482 121.344 1.00 33.72  ? 575 HIS A CD2 1 
ATOM 3523 C CE1 . HIS A 1 601 ? 139.958 122.434 121.689 1.00 33.72  ? 575 HIS A CE1 1 
ATOM 3524 N NE2 . HIS A 1 601 ? 140.905 122.976 120.945 1.00 33.72  ? 575 HIS A NE2 1 
ATOM 3525 N N   . SER A 1 602 ? 142.152 121.945 126.046 1.00 34.18  ? 576 SER A N   1 
ATOM 3526 C CA  . SER A 1 602 ? 141.386 122.772 126.967 1.00 34.18  ? 576 SER A CA  1 
ATOM 3527 C C   . SER A 1 602 ? 142.292 123.690 127.776 1.00 34.18  ? 576 SER A C   1 
ATOM 3528 O O   . SER A 1 602 ? 141.832 124.711 128.296 1.00 34.18  ? 576 SER A O   1 
ATOM 3529 C CB  . SER A 1 602 ? 140.554 121.887 127.889 1.00 34.18  ? 576 SER A CB  1 
ATOM 3530 O OG  . SER A 1 602 ? 139.653 122.660 128.658 1.00 34.18  ? 576 SER A OG  1 
ATOM 3531 N N   . MET A 1 603 ? 143.578 123.351 127.893 1.00 33.70  ? 577 MET A N   1 
ATOM 3532 C CA  . MET A 1 603 ? 144.523 124.298 128.466 1.00 33.70  ? 577 MET A CA  1 
ATOM 3533 C C   . MET A 1 603 ? 144.861 125.400 127.472 1.00 33.70  ? 577 MET A C   1 
ATOM 3534 O O   . MET A 1 603 ? 144.999 126.563 127.860 1.00 33.70  ? 577 MET A O   1 
ATOM 3535 C CB  . MET A 1 603 ? 145.791 123.579 128.919 1.00 33.70  ? 577 MET A CB  1 
ATOM 3536 C CG  . MET A 1 603 ? 146.674 124.432 129.803 1.00 33.70  ? 577 MET A CG  1 
ATOM 3537 S SD  . MET A 1 603 ? 148.423 124.029 129.717 1.00 33.70  ? 577 MET A SD  1 
ATOM 3538 C CE  . MET A 1 603 ? 149.084 125.236 130.863 1.00 33.70  ? 577 MET A CE  1 
ATOM 3539 N N   . VAL A 1 604 ? 144.995 125.057 126.186 1.00 33.90  ? 578 VAL A N   1 
ATOM 3540 C CA  . VAL A 1 604 ? 145.429 126.040 125.193 1.00 33.90  ? 578 VAL A CA  1 
ATOM 3541 C C   . VAL A 1 604 ? 144.306 127.027 124.888 1.00 33.90  ? 578 VAL A C   1 
ATOM 3542 O O   . VAL A 1 604 ? 144.544 128.230 124.716 1.00 33.90  ? 578 VAL A O   1 
ATOM 3543 C CB  . VAL A 1 604 ? 145.936 125.316 123.930 1.00 33.90  ? 578 VAL A CB  1 
ATOM 3544 C CG1 . VAL A 1 604 ? 146.249 126.289 122.810 1.00 33.90  ? 578 VAL A CG1 1 
ATOM 3545 C CG2 . VAL A 1 604 ? 147.175 124.518 124.256 1.00 33.90  ? 578 VAL A CG2 1 
ATOM 3546 N N   . ILE A 1 605 ? 143.065 126.537 124.854 1.00 36.50  ? 579 ILE A N   1 
ATOM 3547 C CA  . ILE A 1 605 ? 141.911 127.375 124.537 1.00 36.50  ? 579 ILE A CA  1 
ATOM 3548 C C   . ILE A 1 605 ? 141.659 128.397 125.644 1.00 36.50  ? 579 ILE A C   1 
ATOM 3549 O O   . ILE A 1 605 ? 141.454 129.587 125.379 1.00 36.50  ? 579 ILE A O   1 
ATOM 3550 C CB  . ILE A 1 605 ? 140.681 126.483 124.288 1.00 36.50  ? 579 ILE A CB  1 
ATOM 3551 C CG1 . ILE A 1 605 ? 140.802 125.789 122.936 1.00 36.50  ? 579 ILE A CG1 1 
ATOM 3552 C CG2 . ILE A 1 605 ? 139.387 127.274 124.365 1.00 36.50  ? 579 ILE A CG2 1 
ATOM 3553 C CD1 . ILE A 1 605 ? 140.794 126.738 121.776 1.00 36.50  ? 579 ILE A CD1 1 
ATOM 3554 N N   . ARG A 1 606 ? 141.696 127.955 126.902 1.00 35.68  ? 580 ARG A N   1 
ATOM 3555 C CA  . ARG A 1 606 ? 141.366 128.853 128.003 1.00 35.68  ? 580 ARG A CA  1 
ATOM 3556 C C   . ARG A 1 606 ? 142.510 129.805 128.342 1.00 35.68  ? 580 ARG A C   1 
ATOM 3557 O O   . ARG A 1 606 ? 142.264 130.887 128.884 1.00 35.68  ? 580 ARG A O   1 
ATOM 3558 C CB  . ARG A 1 606 ? 140.958 128.043 129.231 1.00 35.68  ? 580 ARG A CB  1 
ATOM 3559 C CG  . ARG A 1 606 ? 139.760 127.134 128.996 1.00 35.68  ? 580 ARG A CG  1 
ATOM 3560 C CD  . ARG A 1 606 ? 139.076 126.767 130.303 1.00 35.68  ? 580 ARG A CD  1 
ATOM 3561 N NE  . ARG A 1 606 ? 138.125 125.677 130.128 1.00 35.68  ? 580 ARG A NE  1 
ATOM 3562 C CZ  . ARG A 1 606 ? 138.135 124.552 130.830 1.00 35.68  ? 580 ARG A CZ  1 
ATOM 3563 N NH1 . ARG A 1 606 ? 139.033 124.336 131.778 1.00 35.68  ? 580 ARG A NH1 1 
ATOM 3564 N NH2 . ARG A 1 606 ? 137.225 123.618 130.573 1.00 35.68  ? 580 ARG A NH2 1 
ATOM 3565 N N   . ALA A 1 607 ? 143.757 129.428 128.055 1.00 33.56  ? 581 ALA A N   1 
ATOM 3566 C CA  . ALA A 1 607 ? 144.877 130.322 128.337 1.00 33.56  ? 581 ALA A CA  1 
ATOM 3567 C C   . ALA A 1 607 ? 145.101 131.322 127.211 1.00 33.56  ? 581 ALA A C   1 
ATOM 3568 O O   . ALA A 1 607 ? 144.965 132.533 127.402 1.00 33.56  ? 581 ALA A O   1 
ATOM 3569 C CB  . ALA A 1 607 ? 146.155 129.519 128.570 1.00 33.56  ? 581 ALA A CB  1 
ATOM 3570 N N   . LEU A 1 608 ? 145.449 130.827 126.024 1.00 33.94  ? 582 LEU A N   1 
ATOM 3571 C CA  . LEU A 1 608 ? 145.885 131.712 124.953 1.00 33.94  ? 582 LEU A CA  1 
ATOM 3572 C C   . LEU A 1 608 ? 144.717 132.269 124.155 1.00 33.94  ? 582 LEU A C   1 
ATOM 3573 O O   . LEU A 1 608 ? 144.903 133.190 123.353 1.00 33.94  ? 582 LEU A O   1 
ATOM 3574 C CB  . LEU A 1 608 ? 146.855 130.971 124.033 1.00 33.94  ? 582 LEU A CB  1 
ATOM 3575 C CG  . LEU A 1 608 ? 148.063 130.311 124.696 1.00 33.94  ? 582 LEU A CG  1 
ATOM 3576 C CD1 . LEU A 1 608 ? 148.933 129.636 123.657 1.00 33.94  ? 582 LEU A CD1 1 
ATOM 3577 C CD2 . LEU A 1 608 ? 148.861 131.331 125.480 1.00 33.94  ? 582 LEU A CD2 1 
ATOM 3578 N N   . GLY A 1 609 ? 143.520 131.728 124.349 1.00 35.10  ? 583 GLY A N   1 
ATOM 3579 C CA  . GLY A 1 609 ? 142.342 132.246 123.686 1.00 35.10  ? 583 GLY A CA  1 
ATOM 3580 C C   . GLY A 1 609 ? 141.331 132.797 124.666 1.00 35.10  ? 583 GLY A C   1 
ATOM 3581 O O   . GLY A 1 609 ? 140.528 133.664 124.319 1.00 35.10  ? 583 GLY A O   1 
ATOM 3582 N N   . GLY A 1 610 ? 141.358 132.295 125.900 1.00 36.54  ? 584 GLY A N   1 
ATOM 3583 C CA  . GLY A 1 610 ? 140.427 132.784 126.904 1.00 36.54  ? 584 GLY A CA  1 
ATOM 3584 C C   . GLY A 1 610 ? 140.930 134.017 127.629 1.00 36.54  ? 584 GLY A C   1 
ATOM 3585 O O   . GLY A 1 610 ? 140.164 134.949 127.884 1.00 36.54  ? 584 GLY A O   1 
ATOM 3586 N N   . ILE A 1 611 ? 142.212 134.041 127.976 1.00 36.38  ? 585 ILE A N   1 
ATOM 3587 C CA  . ILE A 1 611 ? 142.803 135.147 128.725 1.00 36.38  ? 585 ILE A CA  1 
ATOM 3588 C C   . ILE A 1 611 ? 143.421 136.182 127.799 1.00 36.38  ? 585 ILE A C   1 
ATOM 3589 O O   . ILE A 1 611 ? 143.129 137.372 127.907 1.00 36.38  ? 585 ILE A O   1 
ATOM 3590 C CB  . ILE A 1 611 ? 143.849 134.620 129.735 1.00 36.38  ? 585 ILE A CB  1 
ATOM 3591 C CG1 . ILE A 1 611 ? 143.211 133.673 130.747 1.00 36.38  ? 585 ILE A CG1 1 
ATOM 3592 C CG2 . ILE A 1 611 ? 144.517 135.769 130.463 1.00 36.38  ? 585 ILE A CG2 1 
ATOM 3593 C CD1 . ILE A 1 611 ? 144.224 132.990 131.633 1.00 36.38  ? 585 ILE A CD1 1 
ATOM 3594 N N   . LEU A 1 612 ? 144.282 135.741 126.878 1.00 35.90  ? 586 LEU A N   1 
ATOM 3595 C CA  . LEU A 1 612 ? 145.077 136.674 126.085 1.00 35.90  ? 586 LEU A CA  1 
ATOM 3596 C C   . LEU A 1 612 ? 144.249 137.396 125.033 1.00 35.90  ? 586 LEU A C   1 
ATOM 3597 O O   . LEU A 1 612 ? 144.531 138.560 124.726 1.00 35.90  ? 586 LEU A O   1 
ATOM 3598 C CB  . LEU A 1 612 ? 146.234 135.941 125.408 1.00 35.90  ? 586 LEU A CB  1 
ATOM 3599 C CG  . LEU A 1 612 ? 147.618 136.003 126.052 1.00 35.90  ? 586 LEU A CG  1 
ATOM 3600 C CD1 . LEU A 1 612 ? 147.625 135.355 127.425 1.00 35.90  ? 586 LEU A CD1 1 
ATOM 3601 C CD2 . LEU A 1 612 ? 148.633 135.339 125.145 1.00 35.90  ? 586 LEU A CD2 1 
ATOM 3602 N N   . ALA A 1 613 ? 143.259 136.717 124.451 1.00 37.20  ? 587 ALA A N   1 
ATOM 3603 C CA  . ALA A 1 613 ? 142.486 137.310 123.361 1.00 37.20  ? 587 ALA A CA  1 
ATOM 3604 C C   . ALA A 1 613 ? 141.650 138.523 123.767 1.00 37.20  ? 587 ALA A C   1 
ATOM 3605 O O   . ALA A 1 613 ? 141.654 139.504 123.001 1.00 37.20  ? 587 ALA A O   1 
ATOM 3606 C CB  . ALA A 1 613 ? 141.646 136.233 122.665 1.00 37.20  ? 587 ALA A CB  1 
ATOM 3607 N N   . PRO A 1 614 ? 140.922 138.552 124.905 1.00 37.85  ? 588 PRO A N   1 
ATOM 3608 C CA  . PRO A 1 614 ? 140.334 139.838 125.325 1.00 37.85  ? 588 PRO A CA  1 
ATOM 3609 C C   . PRO A 1 614 ? 141.359 140.919 125.602 1.00 37.85  ? 588 PRO A C   1 
ATOM 3610 O O   . PRO A 1 614 ? 141.076 142.093 125.343 1.00 37.85  ? 588 PRO A O   1 
ATOM 3611 C CB  . PRO A 1 614 ? 139.552 139.472 126.593 1.00 37.85  ? 588 PRO A CB  1 
ATOM 3612 C CG  . PRO A 1 614 ? 139.220 138.074 126.427 1.00 37.85  ? 588 PRO A CG  1 
ATOM 3613 C CD  . PRO A 1 614 ? 140.408 137.469 125.772 1.00 37.85  ? 588 PRO A CD  1 
ATOM 3614 N N   . ILE A 1 615 ? 142.558 140.550 126.060 1.00 37.31  ? 589 ILE A N   1 
ATOM 3615 C CA  . ILE A 1 615 ? 143.595 141.536 126.346 1.00 37.31  ? 589 ILE A CA  1 
ATOM 3616 C C   . ILE A 1 615 ? 144.088 142.196 125.062 1.00 37.31  ? 589 ILE A C   1 
ATOM 3617 O O   . ILE A 1 615 ? 144.145 143.427 124.971 1.00 37.31  ? 589 ILE A O   1 
ATOM 3618 C CB  . ILE A 1 615 ? 144.746 140.890 127.135 1.00 37.31  ? 589 ILE A CB  1 
ATOM 3619 C CG1 . ILE A 1 615 ? 144.260 140.466 128.520 1.00 37.31  ? 589 ILE A CG1 1 
ATOM 3620 C CG2 . ILE A 1 615 ? 145.907 141.852 127.274 1.00 37.31  ? 589 ILE A CG2 1 
ATOM 3621 C CD1 . ILE A 1 615 ? 145.257 139.641 129.282 1.00 37.31  ? 589 ILE A CD1 1 
ATOM 3622 N N   . TYR A 1 616 ? 144.414 141.404 124.031 1.00 38.61  ? 590 TYR A N   1 
ATOM 3623 C CA  . TYR A 1 616 ? 144.929 142.063 122.832 1.00 38.61  ? 590 TYR A CA  1 
ATOM 3624 C C   . TYR A 1 616 ? 143.817 142.662 121.977 1.00 38.61  ? 590 TYR A C   1 
ATOM 3625 O O   . TYR A 1 616 ? 144.063 143.651 121.270 1.00 38.61  ? 590 TYR A O   1 
ATOM 3626 C CB  . TYR A 1 616 ? 145.834 141.138 121.995 1.00 38.61  ? 590 TYR A CB  1 
ATOM 3627 C CG  . TYR A 1 616 ? 145.337 139.787 121.499 1.00 38.61  ? 590 TYR A CG  1 
ATOM 3628 C CD1 . TYR A 1 616 ? 144.317 139.684 120.559 1.00 38.61  ? 590 TYR A CD1 1 
ATOM 3629 C CD2 . TYR A 1 616 ? 145.979 138.619 121.889 1.00 38.61  ? 590 TYR A CD2 1 
ATOM 3630 C CE1 . TYR A 1 616 ? 143.901 138.453 120.082 1.00 38.61  ? 590 TYR A CE1 1 
ATOM 3631 C CE2 . TYR A 1 616 ? 145.572 137.385 121.415 1.00 38.61  ? 590 TYR A CE2 1 
ATOM 3632 C CZ  . TYR A 1 616 ? 144.536 137.309 120.511 1.00 38.61  ? 590 TYR A CZ  1 
ATOM 3633 O OH  . TYR A 1 616 ? 144.130 136.081 120.044 1.00 38.61  ? 590 TYR A OH  1 
ATOM 3634 N N   . PHE A 1 617 ? 142.596 142.118 122.051 1.00 38.50  ? 591 PHE A N   1 
ATOM 3635 C CA  . PHE A 1 617 ? 141.452 142.772 121.425 1.00 38.50  ? 591 PHE A CA  1 
ATOM 3636 C C   . PHE A 1 617 ? 141.188 144.135 122.053 1.00 38.50  ? 591 PHE A C   1 
ATOM 3637 O O   . PHE A 1 617 ? 140.979 145.121 121.342 1.00 38.50  ? 591 PHE A O   1 
ATOM 3638 C CB  . PHE A 1 617 ? 140.217 141.878 121.534 1.00 38.50  ? 591 PHE A CB  1 
ATOM 3639 C CG  . PHE A 1 617 ? 139.927 141.068 120.298 1.00 38.50  ? 591 PHE A CG  1 
ATOM 3640 C CD1 . PHE A 1 617 ? 140.625 139.903 120.028 1.00 38.50  ? 591 PHE A CD1 1 
ATOM 3641 C CD2 . PHE A 1 617 ? 138.952 141.478 119.404 1.00 38.50  ? 591 PHE A CD2 1 
ATOM 3642 C CE1 . PHE A 1 617 ? 140.350 139.160 118.897 1.00 38.50  ? 591 PHE A CE1 1 
ATOM 3643 C CE2 . PHE A 1 617 ? 138.672 140.737 118.275 1.00 38.50  ? 591 PHE A CE2 1 
ATOM 3644 C CZ  . PHE A 1 617 ? 139.375 139.579 118.022 1.00 38.50  ? 591 PHE A CZ  1 
ATOM 3645 N N   . GLY A 1 618 ? 141.238 144.219 123.386 1.00 45.05  ? 592 GLY A N   1 
ATOM 3646 C CA  . GLY A 1 618 ? 141.072 145.503 124.046 1.00 45.05  ? 592 GLY A CA  1 
ATOM 3647 C C   . GLY A 1 618 ? 142.227 146.452 123.795 1.00 45.05  ? 592 GLY A C   1 
ATOM 3648 O O   . GLY A 1 618 ? 142.036 147.667 123.726 1.00 45.05  ? 592 GLY A O   1 
ATOM 3649 N N   . ALA A 1 619 ? 143.440 145.908 123.652 1.00 45.30  ? 593 ALA A N   1 
ATOM 3650 C CA  . ALA A 1 619 ? 144.599 146.734 123.330 1.00 45.30  ? 593 ALA A CA  1 
ATOM 3651 C C   . ALA A 1 619 ? 144.464 147.373 121.954 1.00 45.30  ? 593 ALA A C   1 
ATOM 3652 O O   . ALA A 1 619 ? 144.761 148.560 121.783 1.00 45.30  ? 593 ALA A O   1 
ATOM 3653 C CB  . ALA A 1 619 ? 145.875 145.898 123.406 1.00 45.30  ? 593 ALA A CB  1 
ATOM 3654 N N   . LEU A 1 620 ? 144.005 146.608 120.962 1.00 47.01  ? 594 LEU A N   1 
ATOM 3655 C CA  . LEU A 1 620 ? 143.795 147.201 119.646 1.00 47.01  ? 594 LEU A CA  1 
ATOM 3656 C C   . LEU A 1 620 ? 142.533 148.052 119.596 1.00 47.01  ? 594 LEU A C   1 
ATOM 3657 O O   . LEU A 1 620 ? 142.405 148.910 118.719 1.00 47.01  ? 594 LEU A O   1 
ATOM 3658 C CB  . LEU A 1 620 ? 143.751 146.118 118.575 1.00 47.01  ? 594 LEU A CB  1 
ATOM 3659 C CG  . LEU A 1 620 ? 145.132 145.695 118.088 1.00 47.01  ? 594 LEU A CG  1 
ATOM 3660 C CD1 . LEU A 1 620 ? 145.036 144.556 117.091 1.00 47.01  ? 594 LEU A CD1 1 
ATOM 3661 C CD2 . LEU A 1 620 ? 145.833 146.888 117.467 1.00 47.01  ? 594 LEU A CD2 1 
ATOM 3662 N N   . ILE A 1 621 ? 141.587 147.829 120.506 1.00 51.28  ? 595 ILE A N   1 
ATOM 3663 C CA  . ILE A 1 621 ? 140.386 148.656 120.530 1.00 51.28  ? 595 ILE A CA  1 
ATOM 3664 C C   . ILE A 1 621 ? 140.689 150.030 121.121 1.00 51.28  ? 595 ILE A C   1 
ATOM 3665 O O   . ILE A 1 621 ? 140.245 151.057 120.594 1.00 51.28  ? 595 ILE A O   1 
ATOM 3666 C CB  . ILE A 1 621 ? 139.266 147.914 121.284 1.00 51.28  ? 595 ILE A CB  1 
ATOM 3667 C CG1 . ILE A 1 621 ? 138.537 146.978 120.321 1.00 51.28  ? 595 ILE A CG1 1 
ATOM 3668 C CG2 . ILE A 1 621 ? 138.285 148.867 121.956 1.00 51.28  ? 595 ILE A CG2 1 
ATOM 3669 C CD1 . ILE A 1 621 ? 137.611 146.024 120.994 1.00 51.28  ? 595 ILE A CD1 1 
ATOM 3670 N N   . ASP A 1 622 ? 141.496 150.076 122.188 1.00 55.04  ? 596 ASP A N   1 
ATOM 3671 C CA  . ASP A 1 622 ? 141.730 151.319 122.919 1.00 55.04  ? 596 ASP A CA  1 
ATOM 3672 C C   . ASP A 1 622 ? 142.585 152.326 122.158 1.00 55.04  ? 596 ASP A C   1 
ATOM 3673 O O   . ASP A 1 622 ? 142.679 153.478 122.588 1.00 55.04  ? 596 ASP A O   1 
ATOM 3674 C CB  . ASP A 1 622 ? 142.385 151.020 124.266 1.00 55.04  ? 596 ASP A CB  1 
ATOM 3675 C CG  . ASP A 1 622 ? 141.451 150.312 125.224 1.00 55.04  ? 596 ASP A CG  1 
ATOM 3676 O OD1 . ASP A 1 622 ? 140.225 150.521 125.129 1.00 55.04  ? 596 ASP A OD1 1 
ATOM 3677 O OD2 . ASP A 1 622 ? 141.945 149.540 126.072 1.00 55.04  ? 596 ASP A OD2 1 
ATOM 3678 N N   . THR A 1 623 ? 143.210 151.935 121.046 1.00 55.49  ? 597 THR A N   1 
ATOM 3679 C CA  . THR A 1 623 ? 143.986 152.905 120.283 1.00 55.49  ? 597 THR A CA  1 
ATOM 3680 C C   . THR A 1 623 ? 143.102 153.771 119.395 1.00 55.49  ? 597 THR A C   1 
ATOM 3681 O O   . THR A 1 623 ? 143.598 154.727 118.791 1.00 55.49  ? 597 THR A O   1 
ATOM 3682 C CB  . THR A 1 623 ? 145.048 152.205 119.434 1.00 55.49  ? 597 THR A CB  1 
ATOM 3683 O OG1 . THR A 1 623 ? 145.937 153.185 118.885 1.00 55.49  ? 597 THR A OG1 1 
ATOM 3684 C CG2 . THR A 1 623 ? 144.405 151.460 118.291 1.00 55.49  ? 597 THR A CG2 1 
ATOM 3685 N N   . THR A 1 624 ? 141.813 153.456 119.301 1.00 60.28  ? 598 THR A N   1 
ATOM 3686 C CA  . THR A 1 624 ? 140.852 154.246 118.548 1.00 60.28  ? 598 THR A CA  1 
ATOM 3687 C C   . THR A 1 624 ? 140.050 155.197 119.427 1.00 60.28  ? 598 THR A C   1 
ATOM 3688 O O   . THR A 1 624 ? 139.100 155.817 118.939 1.00 60.28  ? 598 THR A O   1 
ATOM 3689 C CB  . THR A 1 624 ? 139.895 153.323 117.796 1.00 60.28  ? 598 THR A CB  1 
ATOM 3690 O OG1 . THR A 1 624 ? 138.905 152.835 118.706 1.00 60.28  ? 598 THR A OG1 1 
ATOM 3691 C CG2 . THR A 1 624 ? 140.649 152.148 117.209 1.00 60.28  ? 598 THR A CG2 1 
ATOM 3692 N N   . CYS A 1 625 ? 140.403 155.318 120.702 1.00 68.88  ? 599 CYS A N   1 
ATOM 3693 C CA  . CYS A 1 625 ? 139.662 156.171 121.618 1.00 68.88  ? 599 CYS A CA  1 
ATOM 3694 C C   . CYS A 1 625 ? 139.936 157.641 121.329 1.00 68.88  ? 599 CYS A C   1 
ATOM 3695 O O   . CYS A 1 625 ? 141.082 158.045 121.120 1.00 68.88  ? 599 CYS A O   1 
ATOM 3696 C CB  . CYS A 1 625 ? 140.043 155.838 123.058 1.00 68.88  ? 599 CYS A CB  1 
ATOM 3697 S SG  . CYS A 1 625 ? 139.158 156.763 124.313 1.00 68.88  ? 599 CYS A SG  1 
ATOM 3698 N N   . ILE A 1 626 ? 138.873 158.444 121.318 1.00 77.34  ? 600 ILE A N   1 
ATOM 3699 C CA  . ILE A 1 626 ? 138.997 159.871 121.042 1.00 77.34  ? 600 ILE A CA  1 
ATOM 3700 C C   . ILE A 1 626 ? 139.055 160.640 122.356 1.00 77.34  ? 600 ILE A C   1 
ATOM 3701 O O   . ILE A 1 626 ? 140.003 161.393 122.603 1.00 77.34  ? 600 ILE A O   1 
ATOM 3702 C CB  . ILE A 1 626 ? 137.845 160.370 120.148 1.00 77.34  ? 600 ILE A CB  1 
ATOM 3703 C CG1 . ILE A 1 626 ? 138.077 159.939 118.701 1.00 77.34  ? 600 ILE A CG1 1 
ATOM 3704 C CG2 . ILE A 1 626 ? 137.725 161.884 120.207 1.00 77.34  ? 600 ILE A CG2 1 
ATOM 3705 C CD1 . ILE A 1 626 ? 137.018 160.436 117.737 1.00 77.34  ? 600 ILE A CD1 1 
ATOM 3706 N N   . LYS A 1 627 ? 138.055 160.452 123.213 1.00 77.82  ? 601 LYS A N   1 
ATOM 3707 C CA  . LYS A 1 627 ? 137.975 161.163 124.481 1.00 77.82  ? 601 LYS A CA  1 
ATOM 3708 C C   . LYS A 1 627 ? 138.366 160.195 125.590 1.00 77.82  ? 601 LYS A C   1 
ATOM 3709 O O   . LYS A 1 627 ? 137.642 159.235 125.871 1.00 77.82  ? 601 LYS A O   1 
ATOM 3710 C CB  . LYS A 1 627 ? 136.573 161.733 124.704 1.00 77.82  ? 601 LYS A CB  1 
ATOM 3711 C CG  . LYS A 1 627 ? 136.358 162.611 125.961 1.00 77.82  ? 601 LYS A CG  1 
ATOM 3712 C CD  . LYS A 1 627 ? 137.557 163.466 126.421 1.00 77.82  ? 601 LYS A CD  1 
ATOM 3713 C CE  . LYS A 1 627 ? 137.853 164.646 125.491 1.00 77.82  ? 601 LYS A CE  1 
ATOM 3714 N NZ  . LYS A 1 627 ? 139.179 165.256 125.783 1.00 77.82  ? 601 LYS A NZ  1 
ATOM 3715 N N   . TRP A 1 628 ? 139.508 160.453 126.215 1.00 75.78  ? 602 TRP A N   1 
ATOM 3716 C CA  . TRP A 1 628 ? 139.979 159.661 127.337 1.00 75.78  ? 602 TRP A CA  1 
ATOM 3717 C C   . TRP A 1 628 ? 139.533 160.302 128.644 1.00 75.78  ? 602 TRP A C   1 
ATOM 3718 O O   . TRP A 1 628 ? 139.452 161.527 128.761 1.00 75.78  ? 602 TRP A O   1 
ATOM 3719 C CB  . TRP A 1 628 ? 141.504 159.542 127.311 1.00 75.78  ? 602 TRP A CB  1 
ATOM 3720 C CG  . TRP A 1 628 ? 142.030 158.368 126.538 1.00 75.78  ? 602 TRP A CG  1 
ATOM 3721 C CD1 . TRP A 1 628 ? 142.818 158.412 125.427 1.00 75.78  ? 602 TRP A CD1 1 
ATOM 3722 C CD2 . TRP A 1 628 ? 141.835 156.978 126.834 1.00 75.78  ? 602 TRP A CD2 1 
ATOM 3723 N NE1 . TRP A 1 628 ? 143.113 157.141 125.004 1.00 75.78  ? 602 TRP A NE1 1 
ATOM 3724 C CE2 . TRP A 1 628 ? 142.524 156.243 125.852 1.00 75.78  ? 602 TRP A CE2 1 
ATOM 3725 C CE3 . TRP A 1 628 ? 141.144 156.285 127.831 1.00 75.78  ? 602 TRP A CE3 1 
ATOM 3726 C CZ2 . TRP A 1 628 ? 142.539 154.853 125.837 1.00 75.78  ? 602 TRP A CZ2 1 
ATOM 3727 C CZ3 . TRP A 1 628 ? 141.160 154.905 127.811 1.00 75.78  ? 602 TRP A CZ3 1 
ATOM 3728 C CH2 . TRP A 1 628 ? 141.852 154.204 126.822 1.00 75.78  ? 602 TRP A CH2 1 
ATOM 3729 N N   . SER A 1 629 ? 139.240 159.459 129.628 1.00 87.71  ? 603 SER A N   1 
ATOM 3730 C CA  . SER A 1 629 ? 138.788 159.905 130.938 1.00 87.71  ? 603 SER A CA  1 
ATOM 3731 C C   . SER A 1 629 ? 139.915 159.741 131.946 1.00 87.71  ? 603 SER A C   1 
ATOM 3732 O O   . SER A 1 629 ? 140.537 158.676 132.020 1.00 87.71  ? 603 SER A O   1 
ATOM 3733 C CB  . SER A 1 629 ? 137.557 159.120 131.392 1.00 87.71  ? 603 SER A CB  1 
ATOM 3734 O OG  . SER A 1 629 ? 137.899 157.784 131.713 1.00 87.71  ? 603 SER A OG  1 
ATOM 3735 N N   . THR A 1 630 ? 140.175 160.795 132.714 1.00 97.90  ? 604 THR A N   1 
ATOM 3736 C CA  . THR A 1 630 ? 141.211 160.755 133.735 1.00 97.90  ? 604 THR A CA  1 
ATOM 3737 C C   . THR A 1 630 ? 140.656 160.168 135.027 1.00 97.90  ? 604 THR A C   1 
ATOM 3738 O O   . THR A 1 630 ? 139.573 160.545 135.484 1.00 97.90  ? 604 THR A O   1 
ATOM 3739 C CB  . THR A 1 630 ? 141.764 162.157 133.991 1.00 97.90  ? 604 THR A CB  1 
ATOM 3740 O OG1 . THR A 1 630 ? 141.972 162.824 132.740 1.00 97.90  ? 604 THR A OG1 1 
ATOM 3741 C CG2 . THR A 1 630 ? 143.087 162.082 134.740 1.00 97.90  ? 604 THR A CG2 1 
ATOM 3742 N N   . ASN A 1 631 ? 141.406 159.239 135.612 1.00 105.16 ? 605 ASN A N   1 
ATOM 3743 C CA  . ASN A 1 631 ? 140.985 158.574 136.834 1.00 105.16 ? 605 ASN A CA  1 
ATOM 3744 C C   . ASN A 1 631 ? 141.167 159.495 138.039 1.00 105.16 ? 605 ASN A C   1 
ATOM 3745 O O   . ASN A 1 631 ? 141.793 160.556 137.961 1.00 105.16 ? 605 ASN A O   1 
ATOM 3746 C CB  . ASN A 1 631 ? 141.768 157.276 137.030 1.00 105.16 ? 605 ASN A CB  1 
ATOM 3747 C CG  . ASN A 1 631 ? 140.953 156.203 137.724 1.00 105.16 ? 605 ASN A CG  1 
ATOM 3748 O OD1 . ASN A 1 631 ? 139.912 156.485 138.317 1.00 105.16 ? 605 ASN A OD1 1 
ATOM 3749 N ND2 . ASN A 1 631 ? 141.425 154.964 137.654 1.00 105.16 ? 605 ASN A ND2 1 
ATOM 3750 N N   . ASN A 1 632 ? 140.585 159.077 139.168 1.00 109.68 ? 606 ASN A N   1 
ATOM 3751 C CA  . ASN A 1 632 ? 140.755 159.816 140.416 1.00 109.68 ? 606 ASN A CA  1 
ATOM 3752 C C   . ASN A 1 632 ? 142.195 159.738 140.909 1.00 109.68 ? 606 ASN A C   1 
ATOM 3753 O O   . ASN A 1 632 ? 142.743 160.726 141.414 1.00 109.68 ? 606 ASN A O   1 
ATOM 3754 C CB  . ASN A 1 632 ? 139.791 159.279 141.474 1.00 109.68 ? 606 ASN A CB  1 
ATOM 3755 C CG  . ASN A 1 632 ? 140.107 159.788 142.868 1.00 109.68 ? 606 ASN A CG  1 
ATOM 3756 O OD1 . ASN A 1 632 ? 140.267 160.990 143.082 1.00 109.68 ? 606 ASN A OD1 1 
ATOM 3757 N ND2 . ASN A 1 632 ? 140.197 158.872 143.825 1.00 109.68 ? 606 ASN A ND2 1 
ATOM 3758 N N   . CYS A 1 633 ? 142.827 158.577 140.762 1.00 109.51 ? 607 CYS A N   1 
ATOM 3759 C CA  . CYS A 1 633 ? 144.221 158.392 141.136 1.00 109.51 ? 607 CYS A CA  1 
ATOM 3760 C C   . CYS A 1 633 ? 145.187 158.720 140.005 1.00 109.51 ? 607 CYS A C   1 
ATOM 3761 O O   . CYS A 1 633 ? 146.401 158.592 140.191 1.00 109.51 ? 607 CYS A O   1 
ATOM 3762 C CB  . CYS A 1 633 ? 144.450 156.953 141.610 1.00 109.51 ? 607 CYS A CB  1 
ATOM 3763 S SG  . CYS A 1 633 ? 143.866 155.691 140.456 1.00 109.51 ? 607 CYS A SG  1 
ATOM 3764 N N   . GLY A 1 634 ? 144.682 159.135 138.844 1.00 109.25 ? 608 GLY A N   1 
ATOM 3765 C CA  . GLY A 1 634 ? 145.533 159.477 137.724 1.00 109.25 ? 608 GLY A CA  1 
ATOM 3766 C C   . GLY A 1 634 ? 146.106 158.302 136.967 1.00 109.25 ? 608 GLY A C   1 
ATOM 3767 O O   . GLY A 1 634 ? 147.013 158.497 136.149 1.00 109.25 ? 608 GLY A O   1 
ATOM 3768 N N   . THR A 1 635 ? 145.610 157.094 137.208 1.00 107.29 ? 609 THR A N   1 
ATOM 3769 C CA  . THR A 1 635 ? 146.118 155.897 136.558 1.00 107.29 ? 609 THR A CA  1 
ATOM 3770 C C   . THR A 1 635 ? 145.339 155.635 135.270 1.00 107.29 ? 609 THR A C   1 
ATOM 3771 O O   . THR A 1 635 ? 144.619 156.500 134.764 1.00 107.29 ? 609 THR A O   1 
ATOM 3772 C CB  . THR A 1 635 ? 146.051 154.707 137.514 1.00 107.29 ? 609 THR A CB  1 
ATOM 3773 O OG1 . THR A 1 635 ? 144.722 154.585 138.036 1.00 107.29 ? 609 THR A OG1 1 
ATOM 3774 C CG2 . THR A 1 635 ? 147.031 154.891 138.663 1.00 107.29 ? 609 THR A CG2 1 
ATOM 3775 N N   . ARG A 1 636 ? 145.501 154.432 134.715 1.00 102.60 ? 610 ARG A N   1 
ATOM 3776 C CA  . ARG A 1 636 ? 144.807 154.021 133.500 1.00 102.60 ? 610 ARG A CA  1 
ATOM 3777 C C   . ARG A 1 636 ? 143.307 153.903 133.737 1.00 102.60 ? 610 ARG A C   1 
ATOM 3778 O O   . ARG A 1 636 ? 142.854 153.018 134.470 1.00 102.60 ? 610 ARG A O   1 
ATOM 3779 C CB  . ARG A 1 636 ? 145.373 152.691 132.996 1.00 102.60 ? 610 ARG A CB  1 
ATOM 3780 C CG  . ARG A 1 636 ? 144.671 152.126 131.772 1.00 102.60 ? 610 ARG A CG  1 
ATOM 3781 C CD  . ARG A 1 636 ? 145.285 150.794 131.367 1.00 102.60 ? 610 ARG A CD  1 
ATOM 3782 N NE  . ARG A 1 636 ? 144.611 150.195 130.222 1.00 102.60 ? 610 ARG A NE  1 
ATOM 3783 C CZ  . ARG A 1 636 ? 143.594 149.348 130.310 1.00 102.60 ? 610 ARG A CZ  1 
ATOM 3784 N NH1 . ARG A 1 636 ? 143.096 148.985 131.480 1.00 102.60 ? 610 ARG A NH1 1 
ATOM 3785 N NH2 . ARG A 1 636 ? 143.065 148.852 129.195 1.00 102.60 ? 610 ARG A NH2 1 
ATOM 3786 N N   . GLY A 1 637 ? 142.535 154.788 133.124 1.00 95.40  ? 611 GLY A N   1 
ATOM 3787 C CA  . GLY A 1 637 ? 141.093 154.832 133.290 1.00 95.40  ? 611 GLY A CA  1 
ATOM 3788 C C   . GLY A 1 637 ? 140.369 154.066 132.205 1.00 95.40  ? 611 GLY A C   1 
ATOM 3789 O O   . GLY A 1 637 ? 140.782 152.971 131.807 1.00 95.40  ? 611 GLY A O   1 
ATOM 3790 N N   . SER A 1 638 ? 139.275 154.648 131.721 1.00 86.03  ? 612 SER A N   1 
ATOM 3791 C CA  . SER A 1 638 ? 138.437 154.038 130.700 1.00 86.03  ? 612 SER A CA  1 
ATOM 3792 C C   . SER A 1 638 ? 138.207 155.043 129.579 1.00 86.03  ? 612 SER A C   1 
ATOM 3793 O O   . SER A 1 638 ? 138.550 156.223 129.692 1.00 86.03  ? 612 SER A O   1 
ATOM 3794 C CB  . SER A 1 638 ? 137.101 153.566 131.286 1.00 86.03  ? 612 SER A CB  1 
ATOM 3795 O OG  . SER A 1 638 ? 136.356 154.659 131.795 1.00 86.03  ? 612 SER A OG  1 
ATOM 3796 N N   . CYS A 1 639 ? 137.614 154.566 128.491 1.00 79.64  ? 613 CYS A N   1 
ATOM 3797 C CA  . CYS A 1 639 ? 137.313 155.387 127.331 1.00 79.64  ? 613 CYS A CA  1 
ATOM 3798 C C   . CYS A 1 639 ? 135.824 155.696 127.270 1.00 79.64  ? 613 CYS A C   1 
ATOM 3799 O O   . CYS A 1 639 ? 134.991 154.921 127.746 1.00 79.64  ? 613 CYS A O   1 
ATOM 3800 C CB  . CYS A 1 639 ? 137.746 154.697 126.039 1.00 79.64  ? 613 CYS A CB  1 
ATOM 3801 S SG  . CYS A 1 639 ? 137.455 155.695 124.572 1.00 79.64  ? 613 CYS A SG  1 
ATOM 3802 N N   . ARG A 1 640 ? 135.498 156.843 126.682 1.00 81.22  ? 614 ARG A N   1 
ATOM 3803 C CA  . ARG A 1 640 ? 134.117 157.299 126.572 1.00 81.22  ? 614 ARG A CA  1 
ATOM 3804 C C   . ARG A 1 640 ? 133.594 157.307 125.144 1.00 81.22  ? 614 ARG A C   1 
ATOM 3805 O O   . ARG A 1 640 ? 132.506 156.787 124.894 1.00 81.22  ? 614 ARG A O   1 
ATOM 3806 C CB  . ARG A 1 640 ? 133.968 158.702 127.177 1.00 81.22  ? 614 ARG A CB  1 
ATOM 3807 C CG  . ARG A 1 640 ? 134.587 158.862 128.564 1.00 81.22  ? 614 ARG A CG  1 
ATOM 3808 C CD  . ARG A 1 640 ? 134.081 157.799 129.545 1.00 81.22  ? 614 ARG A CD  1 
ATOM 3809 N NE  . ARG A 1 640 ? 134.323 158.134 130.945 1.00 81.22  ? 614 ARG A NE  1 
ATOM 3810 C CZ  . ARG A 1 640 ? 133.667 159.056 131.639 1.00 81.22  ? 614 ARG A CZ  1 
ATOM 3811 N NH1 . ARG A 1 640 ? 132.645 159.718 131.123 1.00 81.22  ? 614 ARG A NH1 1 
ATOM 3812 N NH2 . ARG A 1 640 ? 134.031 159.301 132.894 1.00 81.22  ? 614 ARG A NH2 1 
ATOM 3813 N N   . THR A 1 641 ? 134.325 157.896 124.198 1.00 75.21  ? 615 THR A N   1 
ATOM 3814 C CA  . THR A 1 641 ? 133.944 157.871 122.792 1.00 75.21  ? 615 THR A CA  1 
ATOM 3815 C C   . THR A 1 641 ? 135.096 157.360 121.941 1.00 75.21  ? 615 THR A C   1 
ATOM 3816 O O   . THR A 1 641 ? 136.268 157.596 122.240 1.00 75.21  ? 615 THR A O   1 
ATOM 3817 C CB  . THR A 1 641 ? 133.520 159.253 122.265 1.00 75.21  ? 615 THR A CB  1 
ATOM 3818 O OG1 . THR A 1 641 ? 134.613 160.172 122.377 1.00 75.21  ? 615 THR A OG1 1 
ATOM 3819 C CG2 . THR A 1 641 ? 132.317 159.777 123.015 1.00 75.21  ? 615 THR A CG2 1 
ATOM 3820 N N   . TYR A 1 642 ? 134.738 156.683 120.856 1.00 66.02  ? 616 TYR A N   1 
ATOM 3821 C CA  . TYR A 1 642 ? 135.682 156.089 119.926 1.00 66.02  ? 616 TYR A CA  1 
ATOM 3822 C C   . TYR A 1 642 ? 135.432 156.642 118.531 1.00 66.02  ? 616 TYR A C   1 
ATOM 3823 O O   . TYR A 1 642 ? 134.308 157.017 118.187 1.00 66.02  ? 616 TYR A O   1 
ATOM 3824 C CB  . TYR A 1 642 ? 135.557 154.555 119.886 1.00 66.02  ? 616 TYR A CB  1 
ATOM 3825 C CG  . TYR A 1 642 ? 135.870 153.828 121.178 1.00 66.02  ? 616 TYR A CG  1 
ATOM 3826 C CD1 . TYR A 1 642 ? 134.958 153.793 122.226 1.00 66.02  ? 616 TYR A CD1 1 
ATOM 3827 C CD2 . TYR A 1 642 ? 137.064 153.142 121.333 1.00 66.02  ? 616 TYR A CD2 1 
ATOM 3828 C CE1 . TYR A 1 642 ? 135.236 153.122 123.395 1.00 66.02  ? 616 TYR A CE1 1 
ATOM 3829 C CE2 . TYR A 1 642 ? 137.352 152.467 122.499 1.00 66.02  ? 616 TYR A CE2 1 
ATOM 3830 C CZ  . TYR A 1 642 ? 136.433 152.461 123.526 1.00 66.02  ? 616 TYR A CZ  1 
ATOM 3831 O OH  . TYR A 1 642 ? 136.711 151.789 124.694 1.00 66.02  ? 616 TYR A OH  1 
ATOM 3832 N N   . ASN A 1 643 ? 136.492 156.698 117.730 1.00 64.55  ? 617 ASN A N   1 
ATOM 3833 C CA  . ASN A 1 643 ? 136.346 156.996 116.311 1.00 64.55  ? 617 ASN A CA  1 
ATOM 3834 C C   . ASN A 1 643 ? 135.696 155.793 115.643 1.00 64.55  ? 617 ASN A C   1 
ATOM 3835 O O   . ASN A 1 643 ? 136.332 154.745 115.502 1.00 64.55  ? 617 ASN A O   1 
ATOM 3836 C CB  . ASN A 1 643 ? 137.703 157.307 115.692 1.00 64.55  ? 617 ASN A CB  1 
ATOM 3837 C CG  . ASN A 1 643 ? 137.597 158.208 114.483 1.00 64.55  ? 617 ASN A CG  1 
ATOM 3838 O OD1 . ASN A 1 643 ? 136.694 158.061 113.662 1.00 64.55  ? 617 ASN A OD1 1 
ATOM 3839 N ND2 . ASN A 1 643 ? 138.526 159.150 114.364 1.00 64.55  ? 617 ASN A ND2 1 
ATOM 3840 N N   . SER A 1 644 ? 134.433 155.956 115.229 1.00 63.76  ? 618 SER A N   1 
ATOM 3841 C CA  . SER A 1 644 ? 133.551 154.819 114.966 1.00 63.76  ? 618 SER A CA  1 
ATOM 3842 C C   . SER A 1 644 ? 134.007 153.996 113.766 1.00 63.76  ? 618 SER A C   1 
ATOM 3843 O O   . SER A 1 644 ? 133.987 152.761 113.814 1.00 63.76  ? 618 SER A O   1 
ATOM 3844 C CB  . SER A 1 644 ? 132.118 155.310 114.769 1.00 63.76  ? 618 SER A CB  1 
ATOM 3845 O OG  . SER A 1 644 ? 131.713 156.143 115.841 1.00 63.76  ? 618 SER A OG  1 
ATOM 3846 N N   . THR A 1 645 ? 134.429 154.656 112.682 1.00 61.92  ? 619 THR A N   1 
ATOM 3847 C CA  . THR A 1 645 ? 134.967 153.916 111.543 1.00 61.92  ? 619 THR A CA  1 
ATOM 3848 C C   . THR A 1 645 ? 136.307 153.273 111.871 1.00 61.92  ? 619 THR A C   1 
ATOM 3849 O O   . THR A 1 645 ? 136.576 152.151 111.439 1.00 61.92  ? 619 THR A O   1 
ATOM 3850 C CB  . THR A 1 645 ? 135.094 154.817 110.313 1.00 61.92  ? 619 THR A CB  1 
ATOM 3851 O OG1 . THR A 1 645 ? 135.990 155.901 110.589 1.00 61.92  ? 619 THR A OG1 1 
ATOM 3852 C CG2 . THR A 1 645 ? 133.738 155.327 109.859 1.00 61.92  ? 619 THR A CG2 1 
ATOM 3853 N N   . SER A 1 646 ? 137.151 153.959 112.644 1.00 59.81  ? 620 SER A N   1 
ATOM 3854 C CA  . SER A 1 646 ? 138.446 153.396 113.023 1.00 59.81  ? 620 SER A CA  1 
ATOM 3855 C C   . SER A 1 646 ? 138.280 152.206 113.962 1.00 59.81  ? 620 SER A C   1 
ATOM 3856 O O   . SER A 1 646 ? 138.915 151.158 113.777 1.00 59.81  ? 620 SER A O   1 
ATOM 3857 C CB  . SER A 1 646 ? 139.306 154.477 113.673 1.00 59.81  ? 620 SER A CB  1 
ATOM 3858 O OG  . SER A 1 646 ? 140.598 153.984 113.968 1.00 59.81  ? 620 SER A OG  1 
ATOM 3859 N N   . PHE A 1 647 ? 137.416 152.358 114.971 1.00 56.22  ? 621 PHE A N   1 
ATOM 3860 C CA  . PHE A 1 647 ? 137.129 151.281 115.915 1.00 56.22  ? 621 PHE A CA  1 
ATOM 3861 C C   . PHE A 1 647 ? 136.480 150.096 115.214 1.00 56.22  ? 621 PHE A C   1 
ATOM 3862 O O   . PHE A 1 647 ? 136.849 148.940 115.465 1.00 56.22  ? 621 PHE A O   1 
ATOM 3863 C CB  . PHE A 1 647 ? 136.246 151.840 117.036 1.00 56.22  ? 621 PHE A CB  1 
ATOM 3864 C CG  . PHE A 1 647 ? 135.599 150.808 117.919 1.00 56.22  ? 621 PHE A CG  1 
ATOM 3865 C CD1 . PHE A 1 647 ? 136.336 149.812 118.539 1.00 56.22  ? 621 PHE A CD1 1 
ATOM 3866 C CD2 . PHE A 1 647 ? 134.245 150.890 118.187 1.00 56.22  ? 621 PHE A CD2 1 
ATOM 3867 C CE1 . PHE A 1 647 ? 135.716 148.892 119.357 1.00 56.22  ? 621 PHE A CE1 1 
ATOM 3868 C CE2 . PHE A 1 647 ? 133.632 149.980 119.010 1.00 56.22  ? 621 PHE A CE2 1 
ATOM 3869 C CZ  . PHE A 1 647 ? 134.369 148.980 119.595 1.00 56.22  ? 621 PHE A CZ  1 
ATOM 3870 N N   . SER A 1 648 ? 135.542 150.370 114.302 1.00 56.90  ? 622 SER A N   1 
ATOM 3871 C CA  . SER A 1 648 ? 134.906 149.309 113.530 1.00 56.90  ? 622 SER A CA  1 
ATOM 3872 C C   . SER A 1 648 ? 135.902 148.611 112.616 1.00 56.90  ? 622 SER A C   1 
ATOM 3873 O O   . SER A 1 648 ? 135.898 147.382 112.520 1.00 56.90  ? 622 SER A O   1 
ATOM 3874 C CB  . SER A 1 648 ? 133.749 149.881 112.718 1.00 56.90  ? 622 SER A CB  1 
ATOM 3875 O OG  . SER A 1 648 ? 132.910 150.679 113.533 1.00 56.90  ? 622 SER A OG  1 
ATOM 3876 N N   . ARG A 1 649 ? 136.780 149.377 111.962 1.00 53.53  ? 623 ARG A N   1 
ATOM 3877 C CA  . ARG A 1 649 ? 137.763 148.801 111.052 1.00 53.53  ? 623 ARG A CA  1 
ATOM 3878 C C   . ARG A 1 649 ? 138.724 147.886 111.792 1.00 53.53  ? 623 ARG A C   1 
ATOM 3879 O O   . ARG A 1 649 ? 138.956 146.753 111.363 1.00 53.53  ? 623 ARG A O   1 
ATOM 3880 C CB  . ARG A 1 649 ? 138.521 149.916 110.333 1.00 53.53  ? 623 ARG A CB  1 
ATOM 3881 C CG  . ARG A 1 649 ? 139.772 149.458 109.615 1.00 53.53  ? 623 ARG A CG  1 
ATOM 3882 C CD  . ARG A 1 649 ? 140.064 150.332 108.408 1.00 53.53  ? 623 ARG A CD  1 
ATOM 3883 N NE  . ARG A 1 649 ? 138.908 150.452 107.527 1.00 53.53  ? 623 ARG A NE  1 
ATOM 3884 C CZ  . ARG A 1 649 ? 138.322 151.598 107.211 1.00 53.53  ? 623 ARG A CZ  1 
ATOM 3885 N NH1 . ARG A 1 649 ? 138.756 152.752 107.691 1.00 53.53  ? 623 ARG A NH1 1 
ATOM 3886 N NH2 . ARG A 1 649 ? 137.274 151.586 106.393 1.00 53.53  ? 623 ARG A NH2 1 
ATOM 3887 N N   . VAL A 1 650 ? 139.207 148.326 112.958 1.00 49.88  ? 624 VAL A N   1 
ATOM 3888 C CA  . VAL A 1 650 ? 140.119 147.506 113.756 1.00 49.88  ? 624 VAL A CA  1 
ATOM 3889 C C   . VAL A 1 650 ? 139.420 146.247 114.266 1.00 49.88  ? 624 VAL A C   1 
ATOM 3890 O O   . VAL A 1 650 ? 139.948 145.137 114.131 1.00 49.88  ? 624 VAL A O   1 
ATOM 3891 C CB  . VAL A 1 650 ? 140.714 148.335 114.908 1.00 49.88  ? 624 VAL A CB  1 
ATOM 3892 C CG1 . VAL A 1 650 ? 141.430 147.440 115.897 1.00 49.88  ? 624 VAL A CG1 1 
ATOM 3893 C CG2 . VAL A 1 650 ? 141.669 149.377 114.359 1.00 49.88  ? 624 VAL A CG2 1 
ATOM 3894 N N   . TYR A 1 651 ? 138.198 146.392 114.795 1.00 46.13  ? 625 TYR A N   1 
ATOM 3895 C CA  . TYR A 1 651 ? 137.500 145.265 115.416 1.00 46.13  ? 625 TYR A CA  1 
ATOM 3896 C C   . TYR A 1 651 ? 137.104 144.201 114.390 1.00 46.13  ? 625 TYR A C   1 
ATOM 3897 O O   . TYR A 1 651 ? 137.481 143.023 114.517 1.00 46.13  ? 625 TYR A O   1 
ATOM 3898 C CB  . TYR A 1 651 ? 136.281 145.801 116.170 1.00 46.13  ? 625 TYR A CB  1 
ATOM 3899 C CG  . TYR A 1 651 ? 135.314 144.774 116.705 1.00 46.13  ? 625 TYR A CG  1 
ATOM 3900 C CD1 . TYR A 1 651 ? 135.591 144.067 117.866 1.00 46.13  ? 625 TYR A CD1 1 
ATOM 3901 C CD2 . TYR A 1 651 ? 134.099 144.548 116.075 1.00 46.13  ? 625 TYR A CD2 1 
ATOM 3902 C CE1 . TYR A 1 651 ? 134.699 143.143 118.362 1.00 46.13  ? 625 TYR A CE1 1 
ATOM 3903 C CE2 . TYR A 1 651 ? 133.204 143.627 116.562 1.00 46.13  ? 625 TYR A CE2 1 
ATOM 3904 C CZ  . TYR A 1 651 ? 133.510 142.931 117.704 1.00 46.13  ? 625 TYR A CZ  1 
ATOM 3905 O OH  . TYR A 1 651 ? 132.617 142.012 118.192 1.00 46.13  ? 625 TYR A OH  1 
ATOM 3906 N N   . LEU A 1 652 ? 136.377 144.608 113.340 1.00 48.93  ? 626 LEU A N   1 
ATOM 3907 C CA  . LEU A 1 652 ? 135.964 143.657 112.310 1.00 48.93  ? 626 LEU A CA  1 
ATOM 3908 C C   . LEU A 1 652 ? 137.144 143.148 111.494 1.00 48.93  ? 626 LEU A C   1 
ATOM 3909 O O   . LEU A 1 652 ? 137.142 141.987 111.080 1.00 48.93  ? 626 LEU A O   1 
ATOM 3910 C CB  . LEU A 1 652 ? 134.908 144.272 111.393 1.00 48.93  ? 626 LEU A CB  1 
ATOM 3911 C CG  . LEU A 1 652 ? 133.764 145.089 111.991 1.00 48.93  ? 626 LEU A CG  1 
ATOM 3912 C CD1 . LEU A 1 652 ? 133.037 145.827 110.894 1.00 48.93  ? 626 LEU A CD1 1 
ATOM 3913 C CD2 . LEU A 1 652 ? 132.802 144.185 112.738 1.00 48.93  ? 626 LEU A CD2 1 
ATOM 3914 N N   . GLY A 1 653 ? 138.173 143.973 111.271 1.00 46.27  ? 627 GLY A N   1 
ATOM 3915 C CA  . GLY A 1 653 ? 139.337 143.494 110.550 1.00 46.27  ? 627 GLY A CA  1 
ATOM 3916 C C   . GLY A 1 653 ? 140.137 142.471 111.326 1.00 46.27  ? 627 GLY A C   1 
ATOM 3917 O O   . GLY A 1 653 ? 140.585 141.475 110.759 1.00 46.27  ? 627 GLY A O   1 
ATOM 3918 N N   . LEU A 1 654 ? 140.317 142.690 112.632 1.00 42.63  ? 628 LEU A N   1 
ATOM 3919 C CA  . LEU A 1 654 ? 141.072 141.745 113.445 1.00 42.63  ? 628 LEU A CA  1 
ATOM 3920 C C   . LEU A 1 654 ? 140.339 140.416 113.548 1.00 42.63  ? 628 LEU A C   1 
ATOM 3921 O O   . LEU A 1 654 ? 140.944 139.347 113.375 1.00 42.63  ? 628 LEU A O   1 
ATOM 3922 C CB  . LEU A 1 654 ? 141.335 142.345 114.825 1.00 42.63  ? 628 LEU A CB  1 
ATOM 3923 C CG  . LEU A 1 654 ? 141.782 141.432 115.963 1.00 42.63  ? 628 LEU A CG  1 
ATOM 3924 C CD1 . LEU A 1 654 ? 143.136 140.814 115.672 1.00 42.63  ? 628 LEU A CD1 1 
ATOM 3925 C CD2 . LEU A 1 654 ? 141.840 142.225 117.243 1.00 42.63  ? 628 LEU A CD2 1 
ATOM 3926 N N   . SER A 1 655 ? 139.014 140.471 113.746 1.00 44.12  ? 629 SER A N   1 
ATOM 3927 C CA  . SER A 1 655 ? 138.213 139.249 113.744 1.00 44.12  ? 629 SER A CA  1 
ATOM 3928 C C   . SER A 1 655 ? 138.240 138.559 112.382 1.00 44.12  ? 629 SER A C   1 
ATOM 3929 O O   . SER A 1 655 ? 138.359 137.328 112.304 1.00 44.12  ? 629 SER A O   1 
ATOM 3930 C CB  . SER A 1 655 ? 136.777 139.570 114.147 1.00 44.12  ? 629 SER A CB  1 
ATOM 3931 O OG  . SER A 1 655 ? 136.736 140.400 115.295 1.00 44.12  ? 629 SER A OG  1 
ATOM 3932 N N   . SER A 1 656 ? 138.197 139.343 111.298 1.00 45.52  ? 630 SER A N   1 
ATOM 3933 C CA  . SER A 1 656 ? 138.131 138.781 109.955 1.00 45.52  ? 630 SER A CA  1 
ATOM 3934 C C   . SER A 1 656 ? 139.426 138.081 109.562 1.00 45.52  ? 630 SER A C   1 
ATOM 3935 O O   . SER A 1 656 ? 139.386 136.946 109.083 1.00 45.52  ? 630 SER A O   1 
ATOM 3936 C CB  . SER A 1 656 ? 137.790 139.881 108.953 1.00 45.52  ? 630 SER A CB  1 
ATOM 3937 O OG  . SER A 1 656 ? 137.693 139.366 107.639 1.00 45.52  ? 630 SER A OG  1 
ATOM 3938 N N   . MET A 1 657 ? 140.585 138.721 109.766 1.00 45.64  ? 631 MET A N   1 
ATOM 3939 C CA  . MET A 1 657 ? 141.839 138.046 109.422 1.00 45.64  ? 631 MET A CA  1 
ATOM 3940 C C   . MET A 1 657 ? 142.168 136.918 110.392 1.00 45.64  ? 631 MET A C   1 
ATOM 3941 O O   . MET A 1 657 ? 142.807 135.932 109.991 1.00 45.64  ? 631 MET A O   1 
ATOM 3942 C CB  . MET A 1 657 ? 143.012 139.021 109.329 1.00 45.64  ? 631 MET A CB  1 
ATOM 3943 C CG  . MET A 1 657 ? 142.707 140.360 108.692 1.00 45.64  ? 631 MET A CG  1 
ATOM 3944 S SD  . MET A 1 657 ? 142.523 140.292 106.903 1.00 45.64  ? 631 MET A SD  1 
ATOM 3945 C CE  . MET A 1 657 ? 141.306 141.582 106.646 1.00 45.64  ? 631 MET A CE  1 
ATOM 3946 N N   . LEU A 1 658 ? 141.717 137.012 111.649 1.00 39.52  ? 632 LEU A N   1 
ATOM 3947 C CA  . LEU A 1 658 ? 141.898 135.887 112.557 1.00 39.52  ? 632 LEU A CA  1 
ATOM 3948 C C   . LEU A 1 658 ? 141.026 134.699 112.151 1.00 39.52  ? 632 LEU A C   1 
ATOM 3949 O O   . LEU A 1 658 ? 141.346 133.554 112.484 1.00 39.52  ? 632 LEU A O   1 
ATOM 3950 C CB  . LEU A 1 658 ? 141.607 136.340 113.987 1.00 39.52  ? 632 LEU A CB  1 
ATOM 3951 C CG  . LEU A 1 658 ? 142.208 135.528 115.130 1.00 39.52  ? 632 LEU A CG  1 
ATOM 3952 C CD1 . LEU A 1 658 ? 143.709 135.629 115.059 1.00 39.52  ? 632 LEU A CD1 1 
ATOM 3953 C CD2 . LEU A 1 658 ? 141.741 136.068 116.452 1.00 39.52  ? 632 LEU A CD2 1 
ATOM 3954 N N   . ARG A 1 659 ? 139.928 134.950 111.425 1.00 43.32  ? 633 ARG A N   1 
ATOM 3955 C CA  . ARG A 1 659 ? 139.157 133.855 110.833 1.00 43.32  ? 633 ARG A CA  1 
ATOM 3956 C C   . ARG A 1 659 ? 139.767 133.358 109.520 1.00 43.32  ? 633 ARG A C   1 
ATOM 3957 O O   . ARG A 1 659 ? 139.678 132.164 109.202 1.00 43.32  ? 633 ARG A O   1 
ATOM 3958 C CB  . ARG A 1 659 ? 137.718 134.303 110.612 1.00 43.32  ? 633 ARG A CB  1 
ATOM 3959 C CG  . ARG A 1 659 ? 136.923 134.428 111.887 1.00 43.32  ? 633 ARG A CG  1 
ATOM 3960 C CD  . ARG A 1 659 ? 135.466 134.682 111.594 1.00 43.32  ? 633 ARG A CD  1 
ATOM 3961 N NE  . ARG A 1 659 ? 134.746 135.056 112.801 1.00 43.32  ? 633 ARG A NE  1 
ATOM 3962 C CZ  . ARG A 1 659 ? 134.053 134.205 113.541 1.00 43.32  ? 633 ARG A CZ  1 
ATOM 3963 N NH1 . ARG A 1 659 ? 133.960 132.929 113.214 1.00 43.32  ? 633 ARG A NH1 1 
ATOM 3964 N NH2 . ARG A 1 659 ? 133.437 134.647 114.633 1.00 43.32  ? 633 ARG A NH2 1 
ATOM 3965 N N   . VAL A 1 660 ? 140.360 134.263 108.732 1.00 42.21  ? 634 VAL A N   1 
ATOM 3966 C CA  . VAL A 1 660 ? 140.975 133.887 107.455 1.00 42.21  ? 634 VAL A CA  1 
ATOM 3967 C C   . VAL A 1 660 ? 142.158 132.948 107.676 1.00 42.21  ? 634 VAL A C   1 
ATOM 3968 O O   . VAL A 1 660 ? 142.327 131.960 106.944 1.00 42.21  ? 634 VAL A O   1 
ATOM 3969 C CB  . VAL A 1 660 ? 141.381 135.148 106.664 1.00 42.21  ? 634 VAL A CB  1 
ATOM 3970 C CG1 . VAL A 1 660 ? 142.256 134.805 105.473 1.00 42.21  ? 634 VAL A CG1 1 
ATOM 3971 C CG2 . VAL A 1 660 ? 140.153 135.851 106.138 1.00 42.21  ? 634 VAL A CG2 1 
ATOM 3972 N N   . SER A 1 661 ? 142.977 133.228 108.697 1.00 43.22  ? 635 SER A N   1 
ATOM 3973 C CA  . SER A 1 661 ? 144.108 132.354 109.010 1.00 43.22  ? 635 SER A CA  1 
ATOM 3974 C C   . SER A 1 661 ? 143.644 130.958 109.420 1.00 43.22  ? 635 SER A C   1 
ATOM 3975 O O   . SER A 1 661 ? 144.254 129.948 109.032 1.00 43.22  ? 635 SER A O   1 
ATOM 3976 C CB  . SER A 1 661 ? 144.953 132.988 110.108 1.00 43.22  ? 635 SER A CB  1 
ATOM 3977 O OG  . SER A 1 661 ? 144.166 133.218 111.261 1.00 43.22  ? 635 SER A OG  1 
ATOM 3978 N N   . SER A 1 662 ? 142.539 130.881 110.167 1.00 41.36  ? 636 SER A N   1 
ATOM 3979 C CA  . SER A 1 662 ? 141.959 129.587 110.510 1.00 41.36  ? 636 SER A CA  1 
ATOM 3980 C C   . SER A 1 662 ? 141.394 128.877 109.287 1.00 41.36  ? 636 SER A C   1 
ATOM 3981 O O   . SER A 1 662 ? 141.429 127.646 109.226 1.00 41.36  ? 636 SER A O   1 
ATOM 3982 C CB  . SER A 1 662 ? 140.875 129.756 111.572 1.00 41.36  ? 636 SER A CB  1 
ATOM 3983 O OG  . SER A 1 662 ? 139.756 130.445 111.050 1.00 41.36  ? 636 SER A OG  1 
ATOM 3984 N N   . LEU A 1 663 ? 140.875 129.624 108.302 1.00 42.42  ? 637 LEU A N   1 
ATOM 3985 C CA  . LEU A 1 663 ? 140.414 128.979 107.071 1.00 42.42  ? 637 LEU A CA  1 
ATOM 3986 C C   . LEU A 1 663 ? 141.577 128.404 106.273 1.00 42.42  ? 637 LEU A C   1 
ATOM 3987 O O   . LEU A 1 663 ? 141.448 127.342 105.649 1.00 42.42  ? 637 LEU A O   1 
ATOM 3988 C CB  . LEU A 1 663 ? 139.644 129.947 106.179 1.00 42.42  ? 637 LEU A CB  1 
ATOM 3989 C CG  . LEU A 1 663 ? 138.295 130.538 106.560 1.00 42.42  ? 637 LEU A CG  1 
ATOM 3990 C CD1 . LEU A 1 663 ? 137.720 131.204 105.326 1.00 42.42  ? 637 LEU A CD1 1 
ATOM 3991 C CD2 . LEU A 1 663 ? 137.362 129.507 107.109 1.00 42.42  ? 637 LEU A CD2 1 
ATOM 3992 N N   . VAL A 1 664 ? 142.707 129.114 106.250 1.00 42.25  ? 638 VAL A N   1 
ATOM 3993 C CA  . VAL A 1 664 ? 143.900 128.600 105.576 1.00 42.25  ? 638 VAL A CA  1 
ATOM 3994 C C   . VAL A 1 664 ? 144.379 127.322 106.254 1.00 42.25  ? 638 VAL A C   1 
ATOM 3995 O O   . VAL A 1 664 ? 144.726 126.331 105.590 1.00 42.25  ? 638 VAL A O   1 
ATOM 3996 C CB  . VAL A 1 664 ? 144.999 129.678 105.547 1.00 42.25  ? 638 VAL A CB  1 
ATOM 3997 C CG1 . VAL A 1 664 ? 146.279 129.128 104.947 1.00 42.25  ? 638 VAL A CG1 1 
ATOM 3998 C CG2 . VAL A 1 664 ? 144.529 130.878 104.755 1.00 42.25  ? 638 VAL A CG2 1 
ATOM 3999 N N   . LEU A 1 665 ? 144.357 127.312 107.590 1.00 41.43  ? 639 LEU A N   1 
ATOM 4000 C CA  . LEU A 1 665 ? 144.728 126.110 108.329 1.00 41.43  ? 639 LEU A CA  1 
ATOM 4001 C C   . LEU A 1 665 ? 143.723 124.975 108.116 1.00 41.43  ? 639 LEU A C   1 
ATOM 4002 O O   . LEU A 1 665 ? 144.112 123.803 108.102 1.00 41.43  ? 639 LEU A O   1 
ATOM 4003 C CB  . LEU A 1 665 ? 144.884 126.445 109.808 1.00 41.43  ? 639 LEU A CB  1 
ATOM 4004 C CG  . LEU A 1 665 ? 146.124 127.275 110.132 1.00 41.43  ? 639 LEU A CG  1 
ATOM 4005 C CD1 . LEU A 1 665 ? 146.044 127.822 111.534 1.00 41.43  ? 639 LEU A CD1 1 
ATOM 4006 C CD2 . LEU A 1 665 ? 147.376 126.440 109.964 1.00 41.43  ? 639 LEU A CD2 1 
ATOM 4007 N N   . TYR A 1 666 ? 142.431 125.303 107.947 1.00 45.92  ? 640 TYR A N   1 
ATOM 4008 C CA  . TYR A 1 666 ? 141.437 124.324 107.491 1.00 45.92  ? 640 TYR A CA  1 
ATOM 4009 C C   . TYR A 1 666 ? 141.816 123.675 106.175 1.00 45.92  ? 640 TYR A C   1 
ATOM 4010 O O   . TYR A 1 666 ? 141.722 122.456 106.040 1.00 45.92  ? 640 TYR A O   1 
ATOM 4011 C CB  . TYR A 1 666 ? 140.063 124.956 107.302 1.00 45.92  ? 640 TYR A CB  1 
ATOM 4012 C CG  . TYR A 1 666 ? 139.296 125.401 108.497 1.00 45.92  ? 640 TYR A CG  1 
ATOM 4013 C CD1 . TYR A 1 666 ? 139.619 124.989 109.766 1.00 45.92  ? 640 TYR A CD1 1 
ATOM 4014 C CD2 . TYR A 1 666 ? 138.253 126.287 108.346 1.00 45.92  ? 640 TYR A CD2 1 
ATOM 4015 C CE1 . TYR A 1 666 ? 138.882 125.411 110.849 1.00 45.92  ? 640 TYR A CE1 1 
ATOM 4016 C CE2 . TYR A 1 666 ? 137.544 126.730 109.418 1.00 45.92  ? 640 TYR A CE2 1 
ATOM 4017 C CZ  . TYR A 1 666 ? 137.857 126.288 110.674 1.00 45.92  ? 640 TYR A CZ  1 
ATOM 4018 O OH  . TYR A 1 666 ? 137.143 126.719 111.766 1.00 45.92  ? 640 TYR A OH  1 
ATOM 4019 N N   . ILE A 1 667 ? 142.162 124.486 105.171 1.00 44.78  ? 641 ILE A N   1 
ATOM 4020 C CA  . ILE A 1 667 ? 142.455 123.942 103.843 1.00 44.78  ? 641 ILE A CA  1 
ATOM 4021 C C   . ILE A 1 667 ? 143.687 123.042 103.891 1.00 44.78  ? 641 ILE A C   1 
ATOM 4022 O O   . ILE A 1 667 ? 143.694 121.938 103.320 1.00 44.78  ? 641 ILE A O   1 
ATOM 4023 C CB  . ILE A 1 667 ? 142.611 125.081 102.818 1.00 44.78  ? 641 ILE A CB  1 
ATOM 4024 C CG1 . ILE A 1 667 ? 141.332 125.914 102.752 1.00 44.78  ? 641 ILE A CG1 1 
ATOM 4025 C CG2 . ILE A 1 667 ? 142.937 124.533 101.440 1.00 44.78  ? 641 ILE A CG2 1 
ATOM 4026 C CD1 . ILE A 1 667 ? 140.116 125.137 102.322 1.00 44.78  ? 641 ILE A CD1 1 
ATOM 4027 N N   . ILE A 1 668 ? 144.715 123.467 104.636 1.00 43.65  ? 642 ILE A N   1 
ATOM 4028 C CA  . ILE A 1 668 ? 145.915 122.647 104.802 1.00 43.65  ? 642 ILE A CA  1 
ATOM 4029 C C   . ILE A 1 668 ? 145.598 121.360 105.566 1.00 43.65  ? 642 ILE A C   1 
ATOM 4030 O O   . ILE A 1 668 ? 146.094 120.282 105.220 1.00 43.65  ? 642 ILE A O   1 
ATOM 4031 C CB  . ILE A 1 668 ? 147.026 123.463 105.488 1.00 43.65  ? 642 ILE A CB  1 
ATOM 4032 C CG1 . ILE A 1 668 ? 147.367 124.692 104.651 1.00 43.65  ? 642 ILE A CG1 1 
ATOM 4033 C CG2 . ILE A 1 668 ? 148.282 122.628 105.662 1.00 43.65  ? 642 ILE A CG2 1 
ATOM 4034 C CD1 . ILE A 1 668 ? 148.466 125.545 105.236 1.00 43.65  ? 642 ILE A CD1 1 
ATOM 4035 N N   . LEU A 1 669 ? 144.727 121.437 106.576 1.00 44.75  ? 643 LEU A N   1 
ATOM 4036 C CA  . LEU A 1 669 ? 144.417 120.254 107.375 1.00 44.75  ? 643 LEU A CA  1 
ATOM 4037 C C   . LEU A 1 669 ? 143.513 119.280 106.625 1.00 44.75  ? 643 LEU A C   1 
ATOM 4038 O O   . LEU A 1 669 ? 143.635 118.063 106.796 1.00 44.75  ? 643 LEU A O   1 
ATOM 4039 C CB  . LEU A 1 669 ? 143.787 120.680 108.699 1.00 44.75  ? 643 LEU A CB  1 
ATOM 4040 C CG  . LEU A 1 669 ? 143.762 119.634 109.812 1.00 44.75  ? 643 LEU A CG  1 
ATOM 4041 C CD1 . LEU A 1 669 ? 145.158 119.265 110.261 1.00 44.75  ? 643 LEU A CD1 1 
ATOM 4042 C CD2 . LEU A 1 669 ? 142.944 120.133 110.987 1.00 44.75  ? 643 LEU A CD2 1 
ATOM 4043 N N   . ILE A 1 670 ? 142.601 119.796 105.796 1.00 46.12  ? 644 ILE A N   1 
ATOM 4044 C CA  . ILE A 1 670 ? 141.789 118.952 104.921 1.00 46.12  ? 644 ILE A CA  1 
ATOM 4045 C C   . ILE A 1 670 ? 142.672 118.217 103.925 1.00 46.12  ? 644 ILE A C   1 
ATOM 4046 O O   . ILE A 1 670 ? 142.511 117.008 103.707 1.00 46.12  ? 644 ILE A O   1 
ATOM 4047 C CB  . ILE A 1 670 ? 140.711 119.800 104.214 1.00 46.12  ? 644 ILE A CB  1 
ATOM 4048 C CG1 . ILE A 1 670 ? 139.599 120.186 105.184 1.00 46.12  ? 644 ILE A CG1 1 
ATOM 4049 C CG2 . ILE A 1 670 ? 140.123 119.081 103.000 1.00 46.12  ? 644 ILE A CG2 1 
ATOM 4050 C CD1 . ILE A 1 670 ? 138.786 119.034 105.626 1.00 46.12  ? 644 ILE A CD1 1 
ATOM 4051 N N   . TYR A 1 671 ? 143.647 118.925 103.340 1.00 49.70  ? 645 TYR A N   1 
ATOM 4052 C CA  . TYR A 1 671 ? 144.587 118.277 102.429 1.00 49.70  ? 645 TYR A CA  1 
ATOM 4053 C C   . TYR A 1 671 ? 145.449 117.251 103.159 1.00 49.70  ? 645 TYR A C   1 
ATOM 4054 O O   . TYR A 1 671 ? 145.748 116.183 102.613 1.00 49.70  ? 645 TYR A O   1 
ATOM 4055 C CB  . TYR A 1 671 ? 145.455 119.333 101.744 1.00 49.70  ? 645 TYR A CB  1 
ATOM 4056 C CG  . TYR A 1 671 ? 146.257 118.825 100.565 1.00 49.70  ? 645 TYR A CG  1 
ATOM 4057 C CD1 . TYR A 1 671 ? 145.722 118.842 99.282  1.00 49.70  ? 645 TYR A CD1 1 
ATOM 4058 C CD2 . TYR A 1 671 ? 147.549 118.335 100.731 1.00 49.70  ? 645 TYR A CD2 1 
ATOM 4059 C CE1 . TYR A 1 671 ? 146.447 118.383 98.199  1.00 49.70  ? 645 TYR A CE1 1 
ATOM 4060 C CE2 . TYR A 1 671 ? 148.280 117.872 99.656  1.00 49.70  ? 645 TYR A CE2 1 
ATOM 4061 C CZ  . TYR A 1 671 ? 147.724 117.900 98.393  1.00 49.70  ? 645 TYR A CZ  1 
ATOM 4062 O OH  . TYR A 1 671 ? 148.452 117.440 97.320  1.00 49.70  ? 645 TYR A OH  1 
ATOM 4063 N N   . ALA A 1 672 ? 145.823 117.543 104.409 1.00 48.37  ? 646 ALA A N   1 
ATOM 4064 C CA  . ALA A 1 672 ? 146.654 116.623 105.181 1.00 48.37  ? 646 ALA A CA  1 
ATOM 4065 C C   . ALA A 1 672 ? 145.903 115.347 105.548 1.00 48.37  ? 646 ALA A C   1 
ATOM 4066 O O   . ALA A 1 672 ? 146.463 114.249 105.461 1.00 48.37  ? 646 ALA A O   1 
ATOM 4067 C CB  . ALA A 1 672 ? 147.173 117.318 106.438 1.00 48.37  ? 646 ALA A CB  1 
ATOM 4068 N N   . MET A 1 673 ? 144.637 115.464 105.959 1.00 50.28  ? 647 MET A N   1 
ATOM 4069 C CA  . MET A 1 673 ? 143.873 114.258 106.266 1.00 50.28  ? 647 MET A CA  1 
ATOM 4070 C C   . MET A 1 673 ? 143.471 113.507 105.004 1.00 50.28  ? 647 MET A C   1 
ATOM 4071 O O   . MET A 1 673 ? 143.274 112.288 105.047 1.00 50.28  ? 647 MET A O   1 
ATOM 4072 C CB  . MET A 1 673 ? 142.631 114.570 107.099 1.00 50.28  ? 647 MET A CB  1 
ATOM 4073 C CG  . MET A 1 673 ? 142.864 115.319 108.384 1.00 50.28  ? 647 MET A CG  1 
ATOM 4074 S SD  . MET A 1 673 ? 141.370 115.231 109.385 1.00 50.28  ? 647 MET A SD  1 
ATOM 4075 C CE  . MET A 1 673 ? 141.285 116.886 110.042 1.00 50.28  ? 647 MET A CE  1 
ATOM 4076 N N   . LYS A 1 674 ? 143.318 114.206 103.877 1.00 50.47  ? 648 LYS A N   1 
ATOM 4077 C CA  . LYS A 1 674 ? 143.025 113.504 102.633 1.00 50.47  ? 648 LYS A CA  1 
ATOM 4078 C C   . LYS A 1 674 ? 144.248 112.748 102.133 1.00 50.47  ? 648 LYS A C   1 
ATOM 4079 O O   . LYS A 1 674 ? 144.123 111.674 101.533 1.00 50.47  ? 648 LYS A O   1 
ATOM 4080 C CB  . LYS A 1 674 ? 142.521 114.486 101.578 1.00 50.47  ? 648 LYS A CB  1 
ATOM 4081 C CG  . LYS A 1 674 ? 141.031 114.770 101.663 1.00 50.47  ? 648 LYS A CG  1 
ATOM 4082 C CD  . LYS A 1 674 ? 140.217 113.559 101.243 1.00 50.47  ? 648 LYS A CD  1 
ATOM 4083 C CE  . LYS A 1 674 ? 140.281 113.339 99.742  1.00 50.47  ? 648 LYS A CE  1 
ATOM 4084 N NZ  . LYS A 1 674 ? 139.528 114.381 98.993  1.00 50.47  ? 648 LYS A NZ  1 
ATOM 4085 N N   . LYS A 1 675 ? 145.442 113.297 102.370 1.00 53.50  ? 649 LYS A N   1 
ATOM 4086 C CA  . LYS A 1 675 ? 146.668 112.582 102.035 1.00 53.50  ? 649 LYS A CA  1 
ATOM 4087 C C   . LYS A 1 675 ? 146.903 111.409 102.979 1.00 53.50  ? 649 LYS A C   1 
ATOM 4088 O O   . LYS A 1 675 ? 147.307 110.325 102.543 1.00 53.50  ? 649 LYS A O   1 
ATOM 4089 C CB  . LYS A 1 675 ? 147.852 113.545 102.070 1.00 53.50  ? 649 LYS A CB  1 
ATOM 4090 C CG  . LYS A 1 675 ? 149.185 112.927 101.687 1.00 53.50  ? 649 LYS A CG  1 
ATOM 4091 C CD  . LYS A 1 675 ? 149.210 112.529 100.222 1.00 53.50  ? 649 LYS A CD  1 
ATOM 4092 C CE  . LYS A 1 675 ? 150.539 111.900 99.846  1.00 53.50  ? 649 LYS A CE  1 
ATOM 4093 N NZ  . LYS A 1 675 ? 151.654 112.883 99.932  1.00 53.50  ? 649 LYS A NZ  1 
ATOM 4094 N N   . LYS A 1 676 ? 146.654 111.606 104.277 1.00 54.81  ? 650 LYS A N   1 
ATOM 4095 C CA  . LYS A 1 676 ? 146.949 110.567 105.258 1.00 54.81  ? 650 LYS A CA  1 
ATOM 4096 C C   . LYS A 1 676 ? 145.933 109.433 105.207 1.00 54.81  ? 650 LYS A C   1 
ATOM 4097 O O   . LYS A 1 676 ? 146.307 108.256 105.273 1.00 54.81  ? 650 LYS A O   1 
ATOM 4098 C CB  . LYS A 1 676 ? 147.004 111.171 106.660 1.00 54.81  ? 650 LYS A CB  1 
ATOM 4099 C CG  . LYS A 1 676 ? 147.541 110.221 107.717 1.00 54.81  ? 650 LYS A CG  1 
ATOM 4100 C CD  . LYS A 1 676 ? 147.724 110.919 109.053 1.00 54.81  ? 650 LYS A CD  1 
ATOM 4101 C CE  . LYS A 1 676 ? 148.405 110.007 110.056 1.00 54.81  ? 650 LYS A CE  1 
ATOM 4102 N NZ  . LYS A 1 676 ? 148.823 110.746 111.276 1.00 54.81  ? 650 LYS A NZ  1 
ATOM 4103 N N   . TYR A 1 677 ? 144.650 109.758 105.092 1.00 55.25  ? 651 TYR A N   1 
ATOM 4104 C CA  . TYR A 1 677 ? 143.611 108.733 105.089 1.00 55.25  ? 651 TYR A CA  1 
ATOM 4105 C C   . TYR A 1 677 ? 143.220 108.352 103.668 1.00 55.25  ? 651 TYR A C   1 
ATOM 4106 O O   . TYR A 1 677 ? 142.170 107.750 103.447 1.00 55.25  ? 651 TYR A O   1 
ATOM 4107 C CB  . TYR A 1 677 ? 142.378 109.208 105.860 1.00 55.25  ? 651 TYR A CB  1 
ATOM 4108 C CG  . TYR A 1 677 ? 142.619 109.432 107.337 1.00 55.25  ? 651 TYR A CG  1 
ATOM 4109 C CD1 . TYR A 1 677 ? 142.743 108.359 108.213 1.00 55.25  ? 651 TYR A CD1 1 
ATOM 4110 C CD2 . TYR A 1 677 ? 142.715 110.718 107.856 1.00 55.25  ? 651 TYR A CD2 1 
ATOM 4111 C CE1 . TYR A 1 677 ? 142.961 108.561 109.562 1.00 55.25  ? 651 TYR A CE1 1 
ATOM 4112 C CE2 . TYR A 1 677 ? 142.932 110.929 109.205 1.00 55.25  ? 651 TYR A CE2 1 
ATOM 4113 C CZ  . TYR A 1 677 ? 143.054 109.848 110.052 1.00 55.25  ? 651 TYR A CZ  1 
ATOM 4114 O OH  . TYR A 1 677 ? 143.271 110.057 111.394 1.00 55.25  ? 651 TYR A OH  1 
ATOM 4115 N N   . GLY B 2 1   ? 133.430 120.274 167.885 1.00 78.73  ? 1   GLY B N   1 
ATOM 4116 C CA  . GLY B 2 1   ? 132.939 121.411 168.640 1.00 78.73  ? 1   GLY B CA  1 
ATOM 4117 C C   . GLY B 2 1   ? 131.587 121.157 169.273 1.00 78.73  ? 1   GLY B C   1 
ATOM 4118 O O   . GLY B 2 1   ? 130.566 121.645 168.789 1.00 78.73  ? 1   GLY B O   1 
ATOM 4119 N N   . SER B 2 2   ? 131.579 120.388 170.362 1.00 78.67  ? 2   SER B N   1 
ATOM 4120 C CA  . SER B 2 2   ? 130.346 120.063 171.079 1.00 78.67  ? 2   SER B CA  1 
ATOM 4121 C C   . SER B 2 2   ? 129.940 121.271 171.916 1.00 78.67  ? 2   SER B C   1 
ATOM 4122 O O   . SER B 2 2   ? 130.248 121.386 173.105 1.00 78.67  ? 2   SER B O   1 
ATOM 4123 C CB  . SER B 2 2   ? 130.535 118.820 171.938 1.00 78.67  ? 2   SER B CB  1 
ATOM 4124 O OG  . SER B 2 2   ? 130.843 117.691 171.140 1.00 78.67  ? 2   SER B OG  1 
ATOM 4125 N N   . SER B 2 3   ? 129.234 122.195 171.269 1.00 70.41  ? 3   SER B N   1 
ATOM 4126 C CA  . SER B 2 3   ? 128.788 123.426 171.904 1.00 70.41  ? 3   SER B CA  1 
ATOM 4127 C C   . SER B 2 3   ? 127.409 123.790 171.377 1.00 70.41  ? 3   SER B C   1 
ATOM 4128 O O   . SER B 2 3   ? 126.974 123.294 170.335 1.00 70.41  ? 3   SER B O   1 
ATOM 4129 C CB  . SER B 2 3   ? 129.770 124.579 171.661 1.00 70.41  ? 3   SER B CB  1 
ATOM 4130 O OG  . SER B 2 3   ? 131.114 124.167 171.840 1.00 70.41  ? 3   SER B OG  1 
ATOM 4131 N N   . SER B 2 4   ? 126.718 124.655 172.118 1.00 63.36  ? 4   SER B N   1 
ATOM 4132 C CA  . SER B 2 4   ? 125.373 125.077 171.744 1.00 63.36  ? 4   SER B CA  1 
ATOM 4133 C C   . SER B 2 4   ? 125.367 126.424 171.027 1.00 63.36  ? 4   SER B C   1 
ATOM 4134 O O   . SER B 2 4   ? 124.904 126.519 169.886 1.00 63.36  ? 4   SER B O   1 
ATOM 4135 C CB  . SER B 2 4   ? 124.484 125.140 172.989 1.00 63.36  ? 4   SER B CB  1 
ATOM 4136 O OG  . SER B 2 4   ? 125.133 125.840 174.036 1.00 63.36  ? 4   SER B OG  1 
ATOM 4137 N N   . GLN B 2 5   ? 125.884 127.464 171.675 1.00 57.55  ? 5   GLN B N   1 
ATOM 4138 C CA  . GLN B 2 5   ? 125.868 128.816 171.133 1.00 57.55  ? 5   GLN B CA  1 
ATOM 4139 C C   . GLN B 2 5   ? 126.969 129.613 171.810 1.00 57.55  ? 5   GLN B C   1 
ATOM 4140 O O   . GLN B 2 5   ? 127.520 129.194 172.832 1.00 57.55  ? 5   GLN B O   1 
ATOM 4141 C CB  . GLN B 2 5   ? 124.511 129.498 171.339 1.00 57.55  ? 5   GLN B CB  1 
ATOM 4142 C CG  . GLN B 2 5   ? 124.110 129.671 172.793 1.00 57.55  ? 5   GLN B CG  1 
ATOM 4143 C CD  . GLN B 2 5   ? 122.967 130.647 172.968 1.00 57.55  ? 5   GLN B CD  1 
ATOM 4144 O OE1 . GLN B 2 5   ? 122.029 130.671 172.173 1.00 57.55  ? 5   GLN B OE1 1 
ATOM 4145 N NE2 . GLN B 2 5   ? 123.038 131.459 174.017 1.00 57.55  ? 5   GLN B NE2 1 
ATOM 4146 N N   . VAL B 2 6   ? 127.288 130.762 171.229 1.00 52.67  ? 6   VAL B N   1 
ATOM 4147 C CA  . VAL B 2 6   ? 128.332 131.615 171.781 1.00 52.67  ? 6   VAL B CA  1 
ATOM 4148 C C   . VAL B 2 6   ? 127.704 132.616 172.737 1.00 52.67  ? 6   VAL B C   1 
ATOM 4149 O O   . VAL B 2 6   ? 126.807 133.379 172.363 1.00 52.67  ? 6   VAL B O   1 
ATOM 4150 C CB  . VAL B 2 6   ? 129.108 132.331 170.667 1.00 52.67  ? 6   VAL B CB  1 
ATOM 4151 C CG1 . VAL B 2 6   ? 130.187 133.199 171.262 1.00 52.67  ? 6   VAL B CG1 1 
ATOM 4152 C CG2 . VAL B 2 6   ? 129.703 131.335 169.712 1.00 52.67  ? 6   VAL B CG2 1 
ATOM 4153 N N   . GLN B 2 7   ? 128.182 132.614 173.976 1.00 51.20  ? 7   GLN B N   1 
ATOM 4154 C CA  . GLN B 2 7   ? 127.781 133.549 175.017 1.00 51.20  ? 7   GLN B CA  1 
ATOM 4155 C C   . GLN B 2 7   ? 128.959 134.493 175.222 1.00 51.20  ? 7   GLN B C   1 
ATOM 4156 O O   . GLN B 2 7   ? 130.094 134.056 175.437 1.00 51.20  ? 7   GLN B O   1 
ATOM 4157 C CB  . GLN B 2 7   ? 127.410 132.815 176.290 1.00 51.20  ? 7   GLN B CB  1 
ATOM 4158 C CG  . GLN B 2 7   ? 126.093 132.072 176.193 1.00 51.20  ? 7   GLN B CG  1 
ATOM 4159 C CD  . GLN B 2 7   ? 126.289 130.576 176.084 1.00 51.20  ? 7   GLN B CD  1 
ATOM 4160 O OE1 . GLN B 2 7   ? 127.416 130.096 175.964 1.00 51.20  ? 7   GLN B OE1 1 
ATOM 4161 N NE2 . GLN B 2 7   ? 125.193 129.829 176.126 1.00 51.20  ? 7   GLN B NE2 1 
ATOM 4162 N N   . LEU B 2 8   ? 128.683 135.787 175.118 1.00 48.83  ? 8   LEU B N   1 
ATOM 4163 C CA  . LEU B 2 8   ? 129.703 136.798 175.341 1.00 48.83  ? 8   LEU B CA  1 
ATOM 4164 C C   . LEU B 2 8   ? 129.459 137.504 176.664 1.00 48.83  ? 8   LEU B C   1 
ATOM 4165 O O   . LEU B 2 8   ? 128.349 137.964 176.946 1.00 48.83  ? 8   LEU B O   1 
ATOM 4166 C CB  . LEU B 2 8   ? 129.699 137.818 174.206 1.00 48.83  ? 8   LEU B CB  1 
ATOM 4167 C CG  . LEU B 2 8   ? 129.669 137.270 172.786 1.00 48.83  ? 8   LEU B CG  1 
ATOM 4168 C CD1 . LEU B 2 8   ? 129.409 138.386 171.820 1.00 48.83  ? 8   LEU B CD1 1 
ATOM 4169 C CD2 . LEU B 2 8   ? 130.997 136.632 172.486 1.00 48.83  ? 8   LEU B CD2 1 
ATOM 4170 N N   . VAL B 2 9   ? 130.506 137.598 177.478 1.00 49.16  ? 9   VAL B N   1 
ATOM 4171 C CA  . VAL B 2 9   ? 130.420 138.282 178.761 1.00 49.16  ? 9   VAL B CA  1 
ATOM 4172 C C   . VAL B 2 9   ? 131.357 139.484 178.739 1.00 49.16  ? 9   VAL B C   1 
ATOM 4173 O O   . VAL B 2 9   ? 132.496 139.393 178.264 1.00 49.16  ? 9   VAL B O   1 
ATOM 4174 C CB  . VAL B 2 9   ? 130.701 137.327 179.947 1.00 49.16  ? 9   VAL B CB  1 
ATOM 4175 C CG1 . VAL B 2 9   ? 132.077 136.675 179.873 1.00 49.16  ? 9   VAL B CG1 1 
ATOM 4176 C CG2 . VAL B 2 9   ? 130.511 138.044 181.279 1.00 49.16  ? 9   VAL B CG2 1 
ATOM 4177 N N   . GLU B 2 10  ? 130.843 140.631 179.168 1.00 50.33  ? 10  GLU B N   1 
ATOM 4178 C CA  . GLU B 2 10  ? 131.651 141.830 179.268 1.00 50.33  ? 10  GLU B CA  1 
ATOM 4179 C C   . GLU B 2 10  ? 132.097 142.049 180.708 1.00 50.33  ? 10  GLU B C   1 
ATOM 4180 O O   . GLU B 2 10  ? 131.454 141.610 181.664 1.00 50.33  ? 10  GLU B O   1 
ATOM 4181 C CB  . GLU B 2 10  ? 130.880 143.057 178.784 1.00 50.33  ? 10  GLU B CB  1 
ATOM 4182 C CG  . GLU B 2 10  ? 130.592 143.097 177.296 1.00 50.33  ? 10  GLU B CG  1 
ATOM 4183 C CD  . GLU B 2 10  ? 129.228 142.538 176.951 1.00 50.33  ? 10  GLU B CD  1 
ATOM 4184 O OE1 . GLU B 2 10  ? 128.704 141.715 177.729 1.00 50.33  ? 10  GLU B OE1 1 
ATOM 4185 O OE2 . GLU B 2 10  ? 128.672 142.934 175.905 1.00 50.33  ? 10  GLU B OE2 1 
ATOM 4186 N N   . SER B 2 11  ? 133.220 142.741 180.848 1.00 49.70  ? 11  SER B N   1 
ATOM 4187 C CA  . SER B 2 11  ? 133.745 143.107 182.154 1.00 49.70  ? 11  SER B CA  1 
ATOM 4188 C C   . SER B 2 11  ? 134.575 144.366 181.984 1.00 49.70  ? 11  SER B C   1 
ATOM 4189 O O   . SER B 2 11  ? 134.999 144.700 180.877 1.00 49.70  ? 11  SER B O   1 
ATOM 4190 C CB  . SER B 2 11  ? 134.585 141.984 182.766 1.00 49.70  ? 11  SER B CB  1 
ATOM 4191 O OG  . SER B 2 11  ? 135.685 141.662 181.934 1.00 49.70  ? 11  SER B OG  1 
ATOM 4192 N N   . GLY B 2 12  ? 134.801 145.060 183.092 1.00 52.47  ? 12  GLY B N   1 
ATOM 4193 C CA  . GLY B 2 12  ? 135.573 146.281 183.063 1.00 52.47  ? 12  GLY B CA  1 
ATOM 4194 C C   . GLY B 2 12  ? 134.771 147.551 182.901 1.00 52.47  ? 12  GLY B C   1 
ATOM 4195 O O   . GLY B 2 12  ? 135.367 148.620 182.730 1.00 52.47  ? 12  GLY B O   1 
ATOM 4196 N N   . GLY B 2 13  ? 133.444 147.473 182.934 1.00 54.84  ? 13  GLY B N   1 
ATOM 4197 C CA  . GLY B 2 13  ? 132.645 148.684 182.917 1.00 54.84  ? 13  GLY B CA  1 
ATOM 4198 C C   . GLY B 2 13  ? 132.627 149.338 184.286 1.00 54.84  ? 13  GLY B C   1 
ATOM 4199 O O   . GLY B 2 13  ? 132.535 148.671 185.318 1.00 54.84  ? 13  GLY B O   1 
ATOM 4200 N N   . GLY B 2 14  ? 132.721 150.660 184.294 1.00 59.89  ? 14  GLY B N   1 
ATOM 4201 C CA  . GLY B 2 14  ? 132.754 151.384 185.549 1.00 59.89  ? 14  GLY B CA  1 
ATOM 4202 C C   . GLY B 2 14  ? 132.776 152.874 185.304 1.00 59.89  ? 14  GLY B C   1 
ATOM 4203 O O   . GLY B 2 14  ? 132.916 153.342 184.170 1.00 59.89  ? 14  GLY B O   1 
ATOM 4204 N N   . LEU B 2 15  ? 132.641 153.615 186.399 1.00 67.12  ? 15  LEU B N   1 
ATOM 4205 C CA  . LEU B 2 15  ? 132.596 155.068 186.329 1.00 67.12  ? 15  LEU B CA  1 
ATOM 4206 C C   . LEU B 2 15  ? 133.979 155.642 186.042 1.00 67.12  ? 15  LEU B C   1 
ATOM 4207 O O   . LEU B 2 15  ? 134.982 155.212 186.617 1.00 67.12  ? 15  LEU B O   1 
ATOM 4208 C CB  . LEU B 2 15  ? 132.048 155.637 187.637 1.00 67.12  ? 15  LEU B CB  1 
ATOM 4209 C CG  . LEU B 2 15  ? 131.829 157.148 187.720 1.00 67.12  ? 15  LEU B CG  1 
ATOM 4210 C CD1 . LEU B 2 15  ? 130.764 157.585 186.734 1.00 67.12  ? 15  LEU B CD1 1 
ATOM 4211 C CD2 . LEU B 2 15  ? 131.451 157.553 189.136 1.00 67.12  ? 15  LEU B CD2 1 
ATOM 4212 N N   . VAL B 2 16  ? 134.026 156.623 185.138 1.00 68.59  ? 16  VAL B N   1 
ATOM 4213 C CA  . VAL B 2 16  ? 135.247 157.351 184.825 1.00 68.59  ? 16  VAL B CA  1 
ATOM 4214 C C   . VAL B 2 16  ? 134.941 158.840 184.882 1.00 68.59  ? 16  VAL B C   1 
ATOM 4215 O O   . VAL B 2 16  ? 133.802 159.272 184.700 1.00 68.59  ? 16  VAL B O   1 
ATOM 4216 C CB  . VAL B 2 16  ? 135.826 156.977 183.444 1.00 68.59  ? 16  VAL B CB  1 
ATOM 4217 N N   . GLN B 2 17  ? 135.980 159.627 185.143 1.00 69.50  ? 17  GLN B N   1 
ATOM 4218 C CA  . GLN B 2 17  ? 135.837 161.069 185.268 1.00 69.50  ? 17  GLN B CA  1 
ATOM 4219 C C   . GLN B 2 17  ? 136.785 161.753 184.299 1.00 69.50  ? 17  GLN B C   1 
ATOM 4220 O O   . GLN B 2 17  ? 137.944 161.347 184.172 1.00 69.50  ? 17  GLN B O   1 
ATOM 4221 C CB  . GLN B 2 17  ? 136.120 161.538 186.701 1.00 69.50  ? 17  GLN B CB  1 
ATOM 4222 N N   . ALA B 2 18  ? 136.269 162.788 183.622 1.00 66.27  ? 18  ALA B N   1 
ATOM 4223 C CA  . ALA B 2 18  ? 136.977 163.615 182.645 1.00 66.27  ? 18  ALA B CA  1 
ATOM 4224 C C   . ALA B 2 18  ? 137.583 162.782 181.523 1.00 66.27  ? 18  ALA B C   1 
ATOM 4225 O O   . ALA B 2 18  ? 137.064 161.714 181.184 1.00 66.27  ? 18  ALA B O   1 
ATOM 4226 C CB  . ALA B 2 18  ? 138.058 164.464 183.325 1.00 66.27  ? 18  ALA B CB  1 
ATOM 4227 N N   . GLY B 2 19  ? 138.680 163.260 180.942 1.00 63.89  ? 19  GLY B N   1 
ATOM 4228 C CA  . GLY B 2 19  ? 139.375 162.508 179.917 1.00 63.89  ? 19  GLY B CA  1 
ATOM 4229 C C   . GLY B 2 19  ? 140.245 161.410 180.492 1.00 63.89  ? 19  GLY B C   1 
ATOM 4230 O O   . GLY B 2 19  ? 141.475 161.477 180.415 1.00 63.89  ? 19  GLY B O   1 
ATOM 4231 N N   . GLY B 2 20  ? 139.618 160.395 181.069 1.00 59.77  ? 20  GLY B N   1 
ATOM 4232 C CA  . GLY B 2 20  ? 140.317 159.295 181.698 1.00 59.77  ? 20  GLY B CA  1 
ATOM 4233 C C   . GLY B 2 20  ? 140.522 158.133 180.757 1.00 59.77  ? 20  GLY B C   1 
ATOM 4234 O O   . GLY B 2 20  ? 140.618 158.297 179.537 1.00 59.77  ? 20  GLY B O   1 
ATOM 4235 N N   . SER B 2 21  ? 140.589 156.937 181.332 1.00 56.82  ? 21  SER B N   1 
ATOM 4236 C CA  . SER B 2 21  ? 140.809 155.739 180.542 1.00 56.82  ? 21  SER B CA  1 
ATOM 4237 C C   . SER B 2 21  ? 140.047 154.579 181.162 1.00 56.82  ? 21  SER B C   1 
ATOM 4238 O O   . SER B 2 21  ? 139.711 154.588 182.348 1.00 56.82  ? 21  SER B O   1 
ATOM 4239 C CB  . SER B 2 21  ? 142.300 155.405 180.434 1.00 56.82  ? 21  SER B CB  1 
ATOM 4240 O OG  . SER B 2 21  ? 142.912 156.161 179.404 1.00 56.82  ? 21  SER B OG  1 
ATOM 4241 N N   . LEU B 2 22  ? 139.780 153.580 180.329 1.00 53.89  ? 22  LEU B N   1 
ATOM 4242 C CA  . LEU B 2 22  ? 139.082 152.372 180.750 1.00 53.89  ? 22  LEU B CA  1 
ATOM 4243 C C   . LEU B 2 22  ? 139.475 151.251 179.801 1.00 53.89  ? 22  LEU B C   1 
ATOM 4244 O O   . LEU B 2 22  ? 140.101 151.483 178.768 1.00 53.89  ? 22  LEU B O   1 
ATOM 4245 C CB  . LEU B 2 22  ? 137.565 152.579 180.775 1.00 53.89  ? 22  LEU B CB  1 
ATOM 4246 C CG  . LEU B 2 22  ? 136.814 151.831 181.880 1.00 53.89  ? 22  LEU B CG  1 
ATOM 4247 C CD1 . LEU B 2 22  ? 137.309 152.267 183.250 1.00 53.89  ? 22  LEU B CD1 1 
ATOM 4248 C CD2 . LEU B 2 22  ? 135.322 152.044 181.761 1.00 53.89  ? 22  LEU B CD2 1 
ATOM 4249 N N   . ARG B 2 23  ? 139.114 150.026 180.168 1.00 49.32  ? 23  ARG B N   1 
ATOM 4250 C CA  . ARG B 2 23  ? 139.413 148.860 179.343 1.00 49.32  ? 23  ARG B CA  1 
ATOM 4251 C C   . ARG B 2 23  ? 138.281 147.860 179.510 1.00 49.32  ? 23  ARG B C   1 
ATOM 4252 O O   . ARG B 2 23  ? 138.066 147.344 180.610 1.00 49.32  ? 23  ARG B O   1 
ATOM 4253 C CB  . ARG B 2 23  ? 140.753 148.239 179.732 1.00 49.32  ? 23  ARG B CB  1 
ATOM 4254 C CG  . ARG B 2 23  ? 141.304 147.250 178.724 1.00 49.32  ? 23  ARG B CG  1 
ATOM 4255 C CD  . ARG B 2 23  ? 142.510 146.528 179.290 1.00 49.32  ? 23  ARG B CD  1 
ATOM 4256 N NE  . ARG B 2 23  ? 143.017 145.499 178.391 1.00 49.32  ? 23  ARG B NE  1 
ATOM 4257 C CZ  . ARG B 2 23  ? 143.828 145.728 177.367 1.00 49.32  ? 23  ARG B CZ  1 
ATOM 4258 N NH1 . ARG B 2 23  ? 144.261 146.946 177.085 1.00 49.32  ? 23  ARG B NH1 1 
ATOM 4259 N NH2 . ARG B 2 23  ? 144.223 144.707 176.613 1.00 49.32  ? 23  ARG B NH2 1 
ATOM 4260 N N   . LEU B 2 24  ? 137.567 147.581 178.425 1.00 46.03  ? 24  LEU B N   1 
ATOM 4261 C CA  . LEU B 2 24  ? 136.437 146.659 178.451 1.00 46.03  ? 24  LEU B CA  1 
ATOM 4262 C C   . LEU B 2 24  ? 136.864 145.338 177.830 1.00 46.03  ? 24  LEU B C   1 
ATOM 4263 O O   . LEU B 2 24  ? 137.377 145.313 176.711 1.00 46.03  ? 24  LEU B O   1 
ATOM 4264 C CB  . LEU B 2 24  ? 135.242 147.235 177.703 1.00 46.03  ? 24  LEU B CB  1 
ATOM 4265 C CG  . LEU B 2 24  ? 134.698 148.566 178.196 1.00 46.03  ? 24  LEU B CG  1 
ATOM 4266 C CD1 . LEU B 2 24  ? 133.824 149.165 177.130 1.00 46.03  ? 24  LEU B CD1 1 
ATOM 4267 C CD2 . LEU B 2 24  ? 133.930 148.357 179.469 1.00 46.03  ? 24  LEU B CD2 1 
ATOM 4268 N N   . SER B 2 25  ? 136.634 144.244 178.542 1.00 46.63  ? 25  SER B N   1 
ATOM 4269 C CA  . SER B 2 25  ? 136.974 142.926 178.038 1.00 46.63  ? 25  SER B CA  1 
ATOM 4270 C C   . SER B 2 25  ? 135.714 142.139 177.713 1.00 46.63  ? 25  SER B C   1 
ATOM 4271 O O   . SER B 2 25  ? 134.707 142.222 178.417 1.00 46.63  ? 25  SER B O   1 
ATOM 4272 C CB  . SER B 2 25  ? 137.813 142.158 179.056 1.00 46.63  ? 25  SER B CB  1 
ATOM 4273 O OG  . SER B 2 25  ? 136.989 141.470 179.977 1.00 46.63  ? 25  SER B OG  1 
ATOM 4274 N N   . CYS B 2 26  ? 135.785 141.367 176.631 1.00 45.81  ? 26  CYS B N   1 
ATOM 4275 C CA  . CYS B 2 26  ? 134.697 140.498 176.194 1.00 45.81  ? 26  CYS B CA  1 
ATOM 4276 C C   . CYS B 2 26  ? 135.241 139.092 176.020 1.00 45.81  ? 26  CYS B C   1 
ATOM 4277 O O   . CYS B 2 26  ? 136.085 138.856 175.148 1.00 45.81  ? 26  CYS B O   1 
ATOM 4278 C CB  . CYS B 2 26  ? 134.075 140.982 174.889 1.00 45.81  ? 26  CYS B CB  1 
ATOM 4279 S SG  . CYS B 2 26  ? 132.812 139.858 174.247 1.00 45.81  ? 26  CYS B SG  1 
ATOM 4280 N N   . ALA B 2 27  ? 134.739 138.170 176.834 1.00 47.55  ? 27  ALA B N   1 
ATOM 4281 C CA  . ALA B 2 27  ? 135.115 136.767 176.772 1.00 47.55  ? 27  ALA B CA  1 
ATOM 4282 C C   . ALA B 2 27  ? 134.012 135.970 176.092 1.00 47.55  ? 27  ALA B C   1 
ATOM 4283 O O   . ALA B 2 27  ? 132.823 136.212 176.323 1.00 47.55  ? 27  ALA B O   1 
ATOM 4284 C CB  . ALA B 2 27  ? 135.382 136.206 178.168 1.00 47.55  ? 27  ALA B CB  1 
ATOM 4285 N N   . ALA B 2 28  ? 134.417 135.020 175.255 1.00 48.55  ? 28  ALA B N   1 
ATOM 4286 C CA  . ALA B 2 28  ? 133.507 134.245 174.425 1.00 48.55  ? 28  ALA B CA  1 
ATOM 4287 C C   . ALA B 2 28  ? 133.526 132.790 174.864 1.00 48.55  ? 28  ALA B C   1 
ATOM 4288 O O   . ALA B 2 28  ? 134.599 132.227 175.100 1.00 48.55  ? 28  ALA B O   1 
ATOM 4289 C CB  . ALA B 2 28  ? 133.897 134.349 172.951 1.00 48.55  ? 28  ALA B CB  1 
ATOM 4290 N N   . SER B 2 29  ? 132.345 132.184 174.970 1.00 52.71  ? 29  SER B N   1 
ATOM 4291 C CA  . SER B 2 29  ? 132.253 130.770 175.309 1.00 52.71  ? 29  SER B CA  1 
ATOM 4292 C C   . SER B 2 29  ? 131.252 130.089 174.391 1.00 52.71  ? 29  SER B C   1 
ATOM 4293 O O   . SER B 2 29  ? 130.130 130.570 174.238 1.00 52.71  ? 29  SER B O   1 
ATOM 4294 C CB  . SER B 2 29  ? 131.843 130.581 176.772 1.00 52.71  ? 29  SER B CB  1 
ATOM 4295 O OG  . SER B 2 29  ? 132.592 131.432 177.621 1.00 52.71  ? 29  SER B OG  1 
ATOM 4296 N N   . GLY B 2 30  ? 131.647 128.969 173.792 1.00 55.58  ? 30  GLY B N   1 
ATOM 4297 C CA  . GLY B 2 30  ? 130.741 128.235 172.926 1.00 55.58  ? 30  GLY B CA  1 
ATOM 4298 C C   . GLY B 2 30  ? 131.414 127.715 171.675 1.00 55.58  ? 30  GLY B C   1 
ATOM 4299 O O   . GLY B 2 30  ? 132.369 126.937 171.760 1.00 55.58  ? 30  GLY B O   1 
ATOM 4300 N N   . PHE B 2 31  ? 130.909 128.116 170.509 1.00 55.51  ? 31  PHE B N   1 
ATOM 4301 C CA  . PHE B 2 31  ? 131.617 127.861 169.264 1.00 55.51  ? 31  PHE B CA  1 
ATOM 4302 C C   . PHE B 2 31  ? 132.917 128.663 169.241 1.00 55.51  ? 31  PHE B C   1 
ATOM 4303 O O   . PHE B 2 31  ? 133.009 129.719 169.874 1.00 55.51  ? 31  PHE B O   1 
ATOM 4304 C CB  . PHE B 2 31  ? 130.762 128.241 168.051 1.00 55.51  ? 31  PHE B CB  1 
ATOM 4305 C CG  . PHE B 2 31  ? 129.564 127.362 167.825 1.00 55.51  ? 31  PHE B CG  1 
ATOM 4306 C CD1 . PHE B 2 31  ? 129.440 126.137 168.456 1.00 55.51  ? 31  PHE B CD1 1 
ATOM 4307 C CD2 . PHE B 2 31  ? 128.556 127.771 166.967 1.00 55.51  ? 31  PHE B CD2 1 
ATOM 4308 C CE1 . PHE B 2 31  ? 128.336 125.338 168.241 1.00 55.51  ? 31  PHE B CE1 1 
ATOM 4309 C CE2 . PHE B 2 31  ? 127.446 126.977 166.744 1.00 55.51  ? 31  PHE B CE2 1 
ATOM 4310 C CZ  . PHE B 2 31  ? 127.337 125.758 167.383 1.00 55.51  ? 31  PHE B CZ  1 
ATOM 4311 N N   . PRO B 2 32  ? 133.946 128.166 168.552 1.00 49.42  ? 32  PRO B N   1 
ATOM 4312 C CA  . PRO B 2 32  ? 135.174 128.956 168.408 1.00 49.42  ? 32  PRO B CA  1 
ATOM 4313 C C   . PRO B 2 32  ? 134.929 130.217 167.598 1.00 49.42  ? 32  PRO B C   1 
ATOM 4314 O O   . PRO B 2 32  ? 134.358 130.180 166.507 1.00 49.42  ? 32  PRO B O   1 
ATOM 4315 C CB  . PRO B 2 32  ? 136.136 128.009 167.682 1.00 49.42  ? 32  PRO B CB  1 
ATOM 4316 C CG  . PRO B 2 32  ? 135.314 126.886 167.178 1.00 49.42  ? 32  PRO B CG  1 
ATOM 4317 C CD  . PRO B 2 32  ? 134.093 126.802 168.017 1.00 49.42  ? 32  PRO B CD  1 
ATOM 4318 N N   . VAL B 2 33  ? 135.365 131.342 168.157 1.00 43.25  ? 33  VAL B N   1 
ATOM 4319 C CA  . VAL B 2 33  ? 135.199 132.644 167.529 1.00 43.25  ? 33  VAL B CA  1 
ATOM 4320 C C   . VAL B 2 33  ? 136.524 133.018 166.880 1.00 43.25  ? 33  VAL B C   1 
ATOM 4321 O O   . VAL B 2 33  ? 136.749 134.172 166.501 1.00 43.25  ? 33  VAL B O   1 
ATOM 4322 C CB  . VAL B 2 33  ? 134.741 133.690 168.559 1.00 43.25  ? 33  VAL B CB  1 
ATOM 4323 C CG1 . VAL B 2 33  ? 133.454 133.247 169.214 1.00 43.25  ? 33  VAL B CG1 1 
ATOM 4324 C CG2 . VAL B 2 33  ? 135.784 133.868 169.619 1.00 43.25  ? 33  VAL B CG2 1 
ATOM 4325 N N   . ASN B 2 34  ? 137.400 132.021 166.730 1.00 41.77  ? 34  ASN B N   1 
ATOM 4326 C CA  . ASN B 2 34  ? 138.742 132.226 166.199 1.00 41.77  ? 34  ASN B CA  1 
ATOM 4327 C C   . ASN B 2 34  ? 138.738 132.593 164.723 1.00 41.77  ? 34  ASN B C   1 
ATOM 4328 O O   . ASN B 2 34  ? 139.717 133.162 164.232 1.00 41.77  ? 34  ASN B O   1 
ATOM 4329 C CB  . ASN B 2 34  ? 139.580 130.966 166.409 1.00 41.77  ? 34  ASN B CB  1 
ATOM 4330 C CG  . ASN B 2 34  ? 139.784 130.641 167.873 1.00 41.77  ? 34  ASN B CG  1 
ATOM 4331 O OD1 . ASN B 2 34  ? 139.307 129.621 168.363 1.00 41.77  ? 34  ASN B OD1 1 
ATOM 4332 N ND2 . ASN B 2 34  ? 140.501 131.505 168.579 1.00 41.77  ? 34  ASN B ND2 1 
ATOM 4333 N N   . LEU B 2 35  ? 137.672 132.270 163.999 1.00 32.87  ? 35  LEU B N   1 
ATOM 4334 C CA  . LEU B 2 35  ? 137.583 132.617 162.590 1.00 32.87  ? 35  LEU B CA  1 
ATOM 4335 C C   . LEU B 2 35  ? 136.844 133.921 162.343 1.00 32.87  ? 35  LEU B C   1 
ATOM 4336 O O   . LEU B 2 35  ? 136.926 134.455 161.236 1.00 32.87  ? 35  LEU B O   1 
ATOM 4337 C CB  . LEU B 2 35  ? 136.892 131.497 161.810 1.00 32.87  ? 35  LEU B CB  1 
ATOM 4338 C CG  . LEU B 2 35  ? 137.566 130.132 161.682 1.00 32.87  ? 35  LEU B CG  1 
ATOM 4339 C CD1 . LEU B 2 35  ? 136.645 129.144 160.995 1.00 32.87  ? 35  LEU B CD1 1 
ATOM 4340 C CD2 . LEU B 2 35  ? 138.853 130.252 160.903 1.00 32.87  ? 35  LEU B CD2 1 
ATOM 4341 N N   . SER B 2 36  ? 136.199 134.487 163.356 1.00 34.05  ? 36  SER B N   1 
ATOM 4342 C CA  . SER B 2 36  ? 135.161 135.485 163.161 1.00 34.05  ? 36  SER B CA  1 
ATOM 4343 C C   . SER B 2 36  ? 135.583 136.851 163.681 1.00 34.05  ? 36  SER B C   1 
ATOM 4344 O O   . SER B 2 36  ? 136.365 136.964 164.627 1.00 34.05  ? 36  SER B O   1 
ATOM 4345 C CB  . SER B 2 36  ? 133.873 135.053 163.857 1.00 34.05  ? 36  SER B CB  1 
ATOM 4346 O OG  . SER B 2 36  ? 132.859 136.020 163.691 1.00 34.05  ? 36  SER B OG  1 
ATOM 4347 N N   . TYR B 2 37  ? 135.054 137.887 163.034 1.00 33.36  ? 37  TYR B N   1 
ATOM 4348 C CA  . TYR B 2 37  ? 135.251 139.261 163.475 1.00 33.36  ? 37  TYR B CA  1 
ATOM 4349 C C   . TYR B 2 37  ? 134.399 139.521 164.710 1.00 33.36  ? 37  TYR B C   1 
ATOM 4350 O O   . TYR B 2 37  ? 133.201 139.228 164.714 1.00 33.36  ? 37  TYR B O   1 
ATOM 4351 C CB  . TYR B 2 37  ? 134.828 140.230 162.370 1.00 33.36  ? 37  TYR B CB  1 
ATOM 4352 C CG  . TYR B 2 37  ? 135.845 140.527 161.288 1.00 33.36  ? 37  TYR B CG  1 
ATOM 4353 C CD1 . TYR B 2 37  ? 136.445 139.503 160.570 1.00 33.36  ? 37  TYR B CD1 1 
ATOM 4354 C CD2 . TYR B 2 37  ? 136.162 141.835 160.953 1.00 33.36  ? 37  TYR B CD2 1 
ATOM 4355 C CE1 . TYR B 2 37  ? 137.358 139.772 159.570 1.00 33.36  ? 37  TYR B CE1 1 
ATOM 4356 C CE2 . TYR B 2 37  ? 137.075 142.114 159.956 1.00 33.36  ? 37  TYR B CE2 1 
ATOM 4357 C CZ  . TYR B 2 37  ? 137.667 141.079 159.268 1.00 33.36  ? 37  TYR B CZ  1 
ATOM 4358 O OH  . TYR B 2 37  ? 138.578 141.351 158.273 1.00 33.36  ? 37  TYR B OH  1 
ATOM 4359 N N   . MET B 2 38  ? 134.990 140.090 165.757 1.00 33.96  ? 38  MET B N   1 
ATOM 4360 C CA  . MET B 2 38  ? 134.205 140.458 166.929 1.00 33.96  ? 38  MET B CA  1 
ATOM 4361 C C   . MET B 2 38  ? 134.193 141.972 167.070 1.00 33.96  ? 38  MET B C   1 
ATOM 4362 O O   . MET B 2 38  ? 135.245 142.615 167.040 1.00 33.96  ? 38  MET B O   1 
ATOM 4363 C CB  . MET B 2 38  ? 134.699 139.784 168.212 1.00 33.96  ? 38  MET B CB  1 
ATOM 4364 C CG  . MET B 2 38  ? 134.773 138.273 168.083 1.00 33.96  ? 38  MET B CG  1 
ATOM 4365 S SD  . MET B 2 38  ? 134.476 137.265 169.558 1.00 33.96  ? 38  MET B SD  1 
ATOM 4366 C CE  . MET B 2 38  ? 135.376 138.055 170.861 1.00 33.96  ? 38  MET B CE  1 
ATOM 4367 N N   . HIS B 2 39  ? 133.000 142.527 167.224 1.00 36.12  ? 39  HIS B N   1 
ATOM 4368 C CA  . HIS B 2 39  ? 132.730 143.949 167.133 1.00 36.12  ? 39  HIS B CA  1 
ATOM 4369 C C   . HIS B 2 39  ? 132.357 144.505 168.497 1.00 36.12  ? 39  HIS B C   1 
ATOM 4370 O O   . HIS B 2 39  ? 131.935 143.781 169.401 1.00 36.12  ? 39  HIS B O   1 
ATOM 4371 C CB  . HIS B 2 39  ? 131.585 144.224 166.156 1.00 36.12  ? 39  HIS B CB  1 
ATOM 4372 C CG  . HIS B 2 39  ? 131.788 143.641 164.795 1.00 36.12  ? 39  HIS B CG  1 
ATOM 4373 N ND1 . HIS B 2 39  ? 132.133 144.405 163.703 1.00 36.12  ? 39  HIS B ND1 1 
ATOM 4374 C CD2 . HIS B 2 39  ? 131.672 142.371 164.343 1.00 36.12  ? 39  HIS B CD2 1 
ATOM 4375 C CE1 . HIS B 2 39  ? 132.236 143.629 162.640 1.00 36.12  ? 39  HIS B CE1 1 
ATOM 4376 N NE2 . HIS B 2 39  ? 131.960 142.390 163.001 1.00 36.12  ? 39  HIS B NE2 1 
ATOM 4377 N N   . TRP B 2 40  ? 132.501 145.818 168.621 1.00 39.22  ? 40  TRP B N   1 
ATOM 4378 C CA  . TRP B 2 40  ? 132.075 146.558 169.797 1.00 39.22  ? 40  TRP B CA  1 
ATOM 4379 C C   . TRP B 2 40  ? 131.063 147.596 169.352 1.00 39.22  ? 40  TRP B C   1 
ATOM 4380 O O   . TRP B 2 40  ? 131.361 148.410 168.471 1.00 39.22  ? 40  TRP B O   1 
ATOM 4381 C CB  . TRP B 2 40  ? 133.264 147.219 170.500 1.00 39.22  ? 40  TRP B CB  1 
ATOM 4382 C CG  . TRP B 2 40  ? 133.920 146.307 171.474 1.00 39.22  ? 40  TRP B CG  1 
ATOM 4383 C CD1 . TRP B 2 40  ? 135.000 145.514 171.253 1.00 39.22  ? 40  TRP B CD1 1 
ATOM 4384 C CD2 . TRP B 2 40  ? 133.525 146.082 172.828 1.00 39.22  ? 40  TRP B CD2 1 
ATOM 4385 N NE1 . TRP B 2 40  ? 135.303 144.805 172.385 1.00 39.22  ? 40  TRP B NE1 1 
ATOM 4386 C CE2 . TRP B 2 40  ? 134.412 145.138 173.369 1.00 39.22  ? 40  TRP B CE2 1 
ATOM 4387 C CE3 . TRP B 2 40  ? 132.506 146.588 173.636 1.00 39.22  ? 40  TRP B CE3 1 
ATOM 4388 C CZ2 . TRP B 2 40  ? 134.313 144.690 174.679 1.00 39.22  ? 40  TRP B CZ2 1 
ATOM 4389 C CZ3 . TRP B 2 40  ? 132.410 146.144 174.934 1.00 39.22  ? 40  TRP B CZ3 1 
ATOM 4390 C CH2 . TRP B 2 40  ? 133.305 145.202 175.443 1.00 39.22  ? 40  TRP B CH2 1 
ATOM 4391 N N   . TYR B 2 41  ? 129.874 147.547 169.953 1.00 40.46  ? 41  TYR B N   1 
ATOM 4392 C CA  . TYR B 2 41  ? 128.770 148.471 169.739 1.00 40.46  ? 41  TYR B CA  1 
ATOM 4393 C C   . TYR B 2 41  ? 128.524 149.268 171.010 1.00 40.46  ? 41  TYR B C   1 
ATOM 4394 O O   . TYR B 2 41  ? 128.963 148.890 172.094 1.00 40.46  ? 41  TYR B O   1 
ATOM 4395 C CB  . TYR B 2 41  ? 127.497 147.712 169.357 1.00 40.46  ? 41  TYR B CB  1 
ATOM 4396 C CG  . TYR B 2 41  ? 127.505 147.122 167.974 1.00 40.46  ? 41  TYR B CG  1 
ATOM 4397 C CD1 . TYR B 2 41  ? 127.221 147.902 166.870 1.00 40.46  ? 41  TYR B CD1 1 
ATOM 4398 C CD2 . TYR B 2 41  ? 127.740 145.774 167.780 1.00 40.46  ? 41  TYR B CD2 1 
ATOM 4399 C CE1 . TYR B 2 41  ? 127.214 147.368 165.604 1.00 40.46  ? 41  TYR B CE1 1 
ATOM 4400 C CE2 . TYR B 2 41  ? 127.736 145.231 166.520 1.00 40.46  ? 41  TYR B CE2 1 
ATOM 4401 C CZ  . TYR B 2 41  ? 127.472 146.028 165.436 1.00 40.46  ? 41  TYR B CZ  1 
ATOM 4402 O OH  . TYR B 2 41  ? 127.465 145.475 164.178 1.00 40.46  ? 41  TYR B OH  1 
ATOM 4403 N N   . ARG B 2 42  ? 127.785 150.365 170.884 1.00 47.37  ? 42  ARG B N   1 
ATOM 4404 C CA  . ARG B 2 42  ? 127.372 151.116 172.059 1.00 47.37  ? 42  ARG B CA  1 
ATOM 4405 C C   . ARG B 2 42  ? 125.898 151.468 171.936 1.00 47.37  ? 42  ARG B C   1 
ATOM 4406 O O   . ARG B 2 42  ? 125.338 151.466 170.837 1.00 47.37  ? 42  ARG B O   1 
ATOM 4407 C CB  . ARG B 2 42  ? 128.203 152.393 172.258 1.00 47.37  ? 42  ARG B CB  1 
ATOM 4408 C CG  . ARG B 2 42  ? 127.740 153.582 171.443 1.00 47.37  ? 42  ARG B CG  1 
ATOM 4409 C CD  . ARG B 2 42  ? 128.569 154.821 171.702 1.00 47.37  ? 42  ARG B CD  1 
ATOM 4410 N NE  . ARG B 2 42  ? 129.842 154.808 170.997 1.00 47.37  ? 42  ARG B NE  1 
ATOM 4411 C CZ  . ARG B 2 42  ? 130.791 155.717 171.166 1.00 47.37  ? 42  ARG B CZ  1 
ATOM 4412 N NH1 . ARG B 2 42  ? 130.653 156.706 172.031 1.00 47.37  ? 42  ARG B NH1 1 
ATOM 4413 N NH2 . ARG B 2 42  ? 131.903 155.635 170.444 1.00 47.37  ? 42  ARG B NH2 1 
ATOM 4414 N N   . GLN B 2 43  ? 125.267 151.736 173.077 1.00 49.86  ? 43  GLN B N   1 
ATOM 4415 C CA  . GLN B 2 43  ? 123.871 152.169 173.143 1.00 49.86  ? 43  GLN B CA  1 
ATOM 4416 C C   . GLN B 2 43  ? 123.838 153.444 173.972 1.00 49.86  ? 43  GLN B C   1 
ATOM 4417 O O   . GLN B 2 43  ? 124.087 153.407 175.180 1.00 49.86  ? 43  GLN B O   1 
ATOM 4418 C CB  . GLN B 2 43  ? 122.982 151.095 173.741 1.00 49.86  ? 43  GLN B CB  1 
ATOM 4419 C CG  . GLN B 2 43  ? 121.536 151.511 173.930 1.00 49.86  ? 43  GLN B CG  1 
ATOM 4420 C CD  . GLN B 2 43  ? 120.695 151.292 172.689 1.00 49.86  ? 43  GLN B CD  1 
ATOM 4421 O OE1 . GLN B 2 43  ? 121.058 150.517 171.807 1.00 49.86  ? 43  GLN B OE1 1 
ATOM 4422 N NE2 . GLN B 2 43  ? 119.561 151.974 172.618 1.00 49.86  ? 43  GLN B NE2 1 
ATOM 4423 N N   . ALA B 2 44  ? 123.568 154.561 173.306 1.00 54.59  ? 44  ALA B N   1 
ATOM 4424 C CA  . ALA B 2 44  ? 123.364 155.828 173.976 1.00 54.59  ? 44  ALA B CA  1 
ATOM 4425 C C   . ALA B 2 44  ? 121.955 155.880 174.562 1.00 54.59  ? 44  ALA B C   1 
ATOM 4426 O O   . ALA B 2 44  ? 121.059 155.171 174.096 1.00 54.59  ? 44  ALA B O   1 
ATOM 4427 C CB  . ALA B 2 44  ? 123.582 156.976 172.992 1.00 54.59  ? 44  ALA B CB  1 
ATOM 4428 N N   . PRO B 2 45  ? 121.735 156.686 175.603 1.00 58.79  ? 45  PRO B N   1 
ATOM 4429 C CA  . PRO B 2 45  ? 120.366 156.861 176.110 1.00 58.79  ? 45  PRO B CA  1 
ATOM 4430 C C   . PRO B 2 45  ? 119.500 157.611 175.106 1.00 58.79  ? 45  PRO B C   1 
ATOM 4431 O O   . PRO B 2 45  ? 119.788 158.753 174.744 1.00 58.79  ? 45  PRO B O   1 
ATOM 4432 C CB  . PRO B 2 45  ? 120.561 157.664 177.402 1.00 58.79  ? 45  PRO B CB  1 
ATOM 4433 C CG  . PRO B 2 45  ? 121.909 158.293 177.267 1.00 58.79  ? 45  PRO B CG  1 
ATOM 4434 C CD  . PRO B 2 45  ? 122.726 157.302 176.504 1.00 58.79  ? 45  PRO B CD  1 
ATOM 4435 N N   . GLY B 2 46  ? 118.434 156.952 174.659 1.00 58.32  ? 46  GLY B N   1 
ATOM 4436 C CA  . GLY B 2 46  ? 117.555 157.539 173.667 1.00 58.32  ? 46  GLY B CA  1 
ATOM 4437 C C   . GLY B 2 46  ? 118.033 157.401 172.239 1.00 58.32  ? 46  GLY B C   1 
ATOM 4438 O O   . GLY B 2 46  ? 117.535 158.107 171.356 1.00 58.32  ? 46  GLY B O   1 
ATOM 4439 N N   . LYS B 2 47  ? 118.989 156.509 171.985 1.00 54.82  ? 47  LYS B N   1 
ATOM 4440 C CA  . LYS B 2 47  ? 119.511 156.305 170.642 1.00 54.82  ? 47  LYS B CA  1 
ATOM 4441 C C   . LYS B 2 47  ? 119.750 154.820 170.417 1.00 54.82  ? 47  LYS B C   1 
ATOM 4442 O O   . LYS B 2 47  ? 119.845 154.036 171.364 1.00 54.82  ? 47  LYS B O   1 
ATOM 4443 C CB  . LYS B 2 47  ? 120.800 157.102 170.408 1.00 54.82  ? 47  LYS B CB  1 
ATOM 4444 C CG  . LYS B 2 47  ? 120.568 158.544 169.995 1.00 54.82  ? 47  LYS B CG  1 
ATOM 4445 C CD  . LYS B 2 47  ? 121.670 159.036 169.071 1.00 54.82  ? 47  LYS B CD  1 
ATOM 4446 C CE  . LYS B 2 47  ? 123.031 158.988 169.746 1.00 54.82  ? 47  LYS B CE  1 
ATOM 4447 N NZ  . LYS B 2 47  ? 123.029 159.722 171.040 1.00 54.82  ? 47  LYS B NZ  1 
ATOM 4448 N N   . GLU B 2 48  ? 119.846 154.442 169.144 1.00 52.81  ? 48  GLU B N   1 
ATOM 4449 C CA  . GLU B 2 48  ? 119.999 153.048 168.761 1.00 52.81  ? 48  GLU B CA  1 
ATOM 4450 C C   . GLU B 2 48  ? 121.463 152.624 168.850 1.00 52.81  ? 48  GLU B C   1 
ATOM 4451 O O   . GLU B 2 48  ? 122.324 153.355 169.345 1.00 52.81  ? 48  GLU B O   1 
ATOM 4452 C CB  . GLU B 2 48  ? 119.447 152.820 167.356 1.00 52.81  ? 48  GLU B CB  1 
ATOM 4453 N N   . ARG B 2 49  ? 121.750 151.424 168.350 1.00 50.19  ? 49  ARG B N   1 
ATOM 4454 C CA  . ARG B 2 49  ? 123.072 150.816 168.486 1.00 50.19  ? 49  ARG B CA  1 
ATOM 4455 C C   . ARG B 2 49  ? 124.053 151.492 167.541 1.00 50.19  ? 49  ARG B C   1 
ATOM 4456 O O   . ARG B 2 49  ? 124.083 151.205 166.343 1.00 50.19  ? 49  ARG B O   1 
ATOM 4457 C CB  . ARG B 2 49  ? 123.009 149.319 168.206 1.00 50.19  ? 49  ARG B CB  1 
ATOM 4458 C CG  . ARG B 2 49  ? 122.325 148.502 169.277 1.00 50.19  ? 49  ARG B CG  1 
ATOM 4459 C CD  . ARG B 2 49  ? 122.351 147.025 168.922 1.00 50.19  ? 49  ARG B CD  1 
ATOM 4460 N NE  . ARG B 2 49  ? 121.511 146.233 169.812 1.00 50.19  ? 49  ARG B NE  1 
ATOM 4461 C CZ  . ARG B 2 49  ? 121.897 145.770 170.993 1.00 50.19  ? 49  ARG B CZ  1 
ATOM 4462 N NH1 . ARG B 2 49  ? 123.110 146.003 171.462 1.00 50.19  ? 49  ARG B NH1 1 
ATOM 4463 N NH2 . ARG B 2 49  ? 121.044 145.057 171.721 1.00 50.19  ? 49  ARG B NH2 1 
ATOM 4464 N N   . GLU B 2 50  ? 124.862 152.396 168.080 1.00 47.95  ? 50  GLU B N   1 
ATOM 4465 C CA  . GLU B 2 50  ? 125.984 152.931 167.329 1.00 47.95  ? 50  GLU B CA  1 
ATOM 4466 C C   . GLU B 2 50  ? 127.102 151.895 167.277 1.00 47.95  ? 50  GLU B C   1 
ATOM 4467 O O   . GLU B 2 50  ? 127.354 151.169 168.240 1.00 47.95  ? 50  GLU B O   1 
ATOM 4468 C CB  . GLU B 2 50  ? 126.474 154.232 167.968 1.00 47.95  ? 50  GLU B CB  1 
ATOM 4469 C CG  . GLU B 2 50  ? 127.549 154.974 167.189 1.00 47.95  ? 50  GLU B CG  1 
ATOM 4470 C CD  . GLU B 2 50  ? 127.830 156.354 167.751 1.00 47.95  ? 50  GLU B CD  1 
ATOM 4471 O OE1 . GLU B 2 50  ? 128.703 157.057 167.202 1.00 47.95  ? 50  GLU B OE1 1 
ATOM 4472 O OE2 . GLU B 2 50  ? 127.175 156.738 168.742 1.00 47.95  ? 50  GLU B OE2 1 
ATOM 4473 N N   . TRP B 2 51  ? 127.765 151.814 166.128 1.00 40.15  ? 51  TRP B N   1 
ATOM 4474 C CA  . TRP B 2 51  ? 128.886 150.907 165.933 1.00 40.15  ? 51  TRP B CA  1 
ATOM 4475 C C   . TRP B 2 51  ? 130.168 151.620 166.330 1.00 40.15  ? 51  TRP B C   1 
ATOM 4476 O O   . TRP B 2 51  ? 130.381 152.772 165.941 1.00 40.15  ? 51  TRP B O   1 
ATOM 4477 C CB  . TRP B 2 51  ? 128.960 150.430 164.483 1.00 40.15  ? 51  TRP B CB  1 
ATOM 4478 C CG  . TRP B 2 51  ? 130.151 149.592 164.196 1.00 40.15  ? 51  TRP B CG  1 
ATOM 4479 C CD1 . TRP B 2 51  ? 130.351 148.299 164.571 1.00 40.15  ? 51  TRP B CD1 1 
ATOM 4480 C CD2 . TRP B 2 51  ? 131.318 149.986 163.473 1.00 40.15  ? 51  TRP B CD2 1 
ATOM 4481 N NE1 . TRP B 2 51  ? 131.570 147.859 164.123 1.00 40.15  ? 51  TRP B NE1 1 
ATOM 4482 C CE2 . TRP B 2 51  ? 132.184 148.879 163.446 1.00 40.15  ? 51  TRP B CE2 1 
ATOM 4483 C CE3 . TRP B 2 51  ? 131.715 151.168 162.845 1.00 40.15  ? 51  TRP B CE3 1 
ATOM 4484 C CZ2 . TRP B 2 51  ? 133.423 148.920 162.818 1.00 40.15  ? 51  TRP B CZ2 1 
ATOM 4485 C CZ3 . TRP B 2 51  ? 132.942 151.206 162.223 1.00 40.15  ? 51  TRP B CZ3 1 
ATOM 4486 C CH2 . TRP B 2 51  ? 133.782 150.091 162.213 1.00 40.15  ? 51  TRP B CH2 1 
ATOM 4487 N N   . VAL B 2 52  ? 131.009 150.948 167.116 1.00 39.64  ? 52  VAL B N   1 
ATOM 4488 C CA  . VAL B 2 52  ? 132.199 151.594 167.661 1.00 39.64  ? 52  VAL B CA  1 
ATOM 4489 C C   . VAL B 2 52  ? 133.472 151.036 167.039 1.00 39.64  ? 52  VAL B C   1 
ATOM 4490 O O   . VAL B 2 52  ? 134.278 151.791 166.488 1.00 39.64  ? 52  VAL B O   1 
ATOM 4491 C CB  . VAL B 2 52  ? 132.252 151.468 169.193 1.00 39.64  ? 52  VAL B CB  1 
ATOM 4492 C CG1 . VAL B 2 52  ? 133.283 152.418 169.759 1.00 39.64  ? 52  VAL B CG1 1 
ATOM 4493 C CG2 . VAL B 2 52  ? 130.892 151.737 169.792 1.00 39.64  ? 52  VAL B CG2 1 
ATOM 4494 N N   . ALA B 2 53  ? 133.681 149.727 167.124 1.00 36.55  ? 53  ALA B N   1 
ATOM 4495 C CA  . ALA B 2 53  ? 134.974 149.195 166.710 1.00 36.55  ? 53  ALA B CA  1 
ATOM 4496 C C   . ALA B 2 53  ? 134.816 147.768 166.213 1.00 36.55  ? 53  ALA B C   1 
ATOM 4497 O O   . ALA B 2 53  ? 133.782 147.133 166.413 1.00 36.55  ? 53  ALA B O   1 
ATOM 4498 C CB  . ALA B 2 53  ? 135.988 149.263 167.854 1.00 36.55  ? 53  ALA B CB  1 
ATOM 4499 N N   . ALA B 2 54  ? 135.867 147.267 165.569 1.00 37.59  ? 54  ALA B N   1 
ATOM 4500 C CA  . ALA B 2 54  ? 135.880 145.900 165.067 1.00 37.59  ? 54  ALA B CA  1 
ATOM 4501 C C   . ALA B 2 54  ? 137.313 145.395 165.017 1.00 37.59  ? 54  ALA B C   1 
ATOM 4502 O O   . ALA B 2 54  ? 138.262 146.177 164.931 1.00 37.59  ? 54  ALA B O   1 
ATOM 4503 C CB  . ALA B 2 54  ? 135.238 145.805 163.682 1.00 37.59  ? 54  ALA B CB  1 
ATOM 4504 N N   . ILE B 2 55  ? 137.454 144.072 165.064 1.00 34.63  ? 55  ILE B N   1 
ATOM 4505 C CA  . ILE B 2 55  ? 138.748 143.405 164.977 1.00 34.63  ? 55  ILE B CA  1 
ATOM 4506 C C   . ILE B 2 55  ? 138.580 142.215 164.042 1.00 34.63  ? 55  ILE B C   1 
ATOM 4507 O O   . ILE B 2 55  ? 137.483 141.670 163.897 1.00 34.63  ? 55  ILE B O   1 
ATOM 4508 C CB  . ILE B 2 55  ? 139.282 142.991 166.384 1.00 34.63  ? 55  ILE B CB  1 
ATOM 4509 C CG1 . ILE B 2 55  ? 140.753 142.550 166.357 1.00 34.63  ? 55  ILE B CG1 1 
ATOM 4510 C CG2 . ILE B 2 55  ? 138.455 141.884 166.998 1.00 34.63  ? 55  ILE B CG2 1 
ATOM 4511 C CD1 . ILE B 2 55  ? 141.744 143.662 166.368 1.00 34.63  ? 55  ILE B CD1 1 
ATOM 4512 N N   . SER B 2 56  ? 139.664 141.836 163.370 1.00 37.28  ? 56  SER B N   1 
ATOM 4513 C CA  . SER B 2 56  ? 139.636 140.710 162.454 1.00 37.28  ? 56  SER B CA  1 
ATOM 4514 C C   . SER B 2 56  ? 139.731 139.395 163.218 1.00 37.28  ? 56  SER B C   1 
ATOM 4515 O O   . SER B 2 56  ? 139.634 139.342 164.445 1.00 37.28  ? 56  SER B O   1 
ATOM 4516 C CB  . SER B 2 56  ? 140.775 140.818 161.447 1.00 37.28  ? 56  SER B CB  1 
ATOM 4517 O OG  . SER B 2 56  ? 140.618 141.961 160.631 1.00 37.28  ? 56  SER B OG  1 
ATOM 4518 N N   . SER B 2 57  ? 139.922 138.314 162.461 1.00 36.45  ? 57  SER B N   1 
ATOM 4519 C CA  . SER B 2 57  ? 140.059 136.990 163.057 1.00 36.45  ? 57  SER B CA  1 
ATOM 4520 C C   . SER B 2 57  ? 141.354 136.861 163.845 1.00 36.45  ? 57  SER B C   1 
ATOM 4521 O O   . SER B 2 57  ? 141.361 136.362 164.976 1.00 36.45  ? 57  SER B O   1 
ATOM 4522 C CB  . SER B 2 57  ? 140.002 135.925 161.968 1.00 36.45  ? 57  SER B CB  1 
ATOM 4523 O OG  . SER B 2 57  ? 140.173 134.641 162.530 1.00 36.45  ? 57  SER B OG  1 
ATOM 4524 N N   . TRP B 2 58  ? 142.465 137.297 163.259 1.00 41.96  ? 58  TRP B N   1 
ATOM 4525 C CA  . TRP B 2 58  ? 143.770 137.208 163.891 1.00 41.96  ? 58  TRP B CA  1 
ATOM 4526 C C   . TRP B 2 58  ? 144.334 138.575 164.245 1.00 41.96  ? 58  TRP B C   1 
ATOM 4527 O O   . TRP B 2 58  ? 145.535 138.692 164.498 1.00 41.96  ? 58  TRP B O   1 
ATOM 4528 C CB  . TRP B 2 58  ? 144.740 136.450 162.984 1.00 41.96  ? 58  TRP B CB  1 
ATOM 4529 C CG  . TRP B 2 58  ? 144.397 134.994 162.829 1.00 41.96  ? 58  TRP B CG  1 
ATOM 4530 C CD1 . TRP B 2 58  ? 143.666 134.427 161.828 1.00 41.96  ? 58  TRP B CD1 1 
ATOM 4531 C CD2 . TRP B 2 58  ? 144.774 133.924 163.705 1.00 41.96  ? 58  TRP B CD2 1 
ATOM 4532 N NE1 . TRP B 2 58  ? 143.562 133.072 162.024 1.00 41.96  ? 58  TRP B NE1 1 
ATOM 4533 C CE2 . TRP B 2 58  ? 144.233 132.737 163.171 1.00 41.96  ? 58  TRP B CE2 1 
ATOM 4534 C CE3 . TRP B 2 58  ? 145.515 133.853 164.888 1.00 41.96  ? 58  TRP B CE3 1 
ATOM 4535 C CZ2 . TRP B 2 58  ? 144.409 131.496 163.779 1.00 41.96  ? 58  TRP B CZ2 1 
ATOM 4536 C CZ3 . TRP B 2 58  ? 145.690 132.619 165.490 1.00 41.96  ? 58  TRP B CZ3 1 
ATOM 4537 C CH2 . TRP B 2 58  ? 145.140 131.458 164.934 1.00 41.96  ? 58  TRP B CH2 1 
ATOM 4538 N N   . GLY B 2 59  ? 143.497 139.607 164.264 1.00 37.91  ? 59  GLY B N   1 
ATOM 4539 C CA  . GLY B 2 59  ? 143.945 140.936 164.623 1.00 37.91  ? 59  GLY B CA  1 
ATOM 4540 C C   . GLY B 2 59  ? 144.749 141.648 163.565 1.00 37.91  ? 59  GLY B C   1 
ATOM 4541 O O   . GLY B 2 59  ? 145.471 142.594 163.889 1.00 37.91  ? 59  GLY B O   1 
ATOM 4542 N N   . TRP B 2 60  ? 144.654 141.224 162.305 1.00 39.39  ? 60  TRP B N   1 
ATOM 4543 C CA  . TRP B 2 60  ? 145.439 141.856 161.251 1.00 39.39  ? 60  TRP B CA  1 
ATOM 4544 C C   . TRP B 2 60  ? 144.844 143.192 160.822 1.00 39.39  ? 60  TRP B C   1 
ATOM 4545 O O   . TRP B 2 60  ? 145.586 144.135 160.527 1.00 39.39  ? 60  TRP B O   1 
ATOM 4546 C CB  . TRP B 2 60  ? 145.566 140.919 160.047 1.00 39.39  ? 60  TRP B CB  1 
ATOM 4547 C CG  . TRP B 2 60  ? 146.350 139.656 160.305 1.00 39.39  ? 60  TRP B CG  1 
ATOM 4548 C CD1 . TRP B 2 60  ? 146.983 139.297 161.460 1.00 39.39  ? 60  TRP B CD1 1 
ATOM 4549 C CD2 . TRP B 2 60  ? 146.564 138.580 159.386 1.00 39.39  ? 60  TRP B CD2 1 
ATOM 4550 N NE1 . TRP B 2 60  ? 147.578 138.071 161.315 1.00 39.39  ? 60  TRP B NE1 1 
ATOM 4551 C CE2 . TRP B 2 60  ? 147.335 137.608 160.050 1.00 39.39  ? 60  TRP B CE2 1 
ATOM 4552 C CE3 . TRP B 2 60  ? 146.176 138.344 158.064 1.00 39.39  ? 60  TRP B CE3 1 
ATOM 4553 C CZ2 . TRP B 2 60  ? 147.728 136.423 159.439 1.00 39.39  ? 60  TRP B CZ2 1 
ATOM 4554 C CZ3 . TRP B 2 60  ? 146.566 137.165 157.459 1.00 39.39  ? 60  TRP B CZ3 1 
ATOM 4555 C CH2 . TRP B 2 60  ? 147.334 136.220 158.146 1.00 39.39  ? 60  TRP B CH2 1 
ATOM 4556 N N   . HIS B 2 61  ? 143.518 143.297 160.781 1.00 37.21  ? 61  HIS B N   1 
ATOM 4557 C CA  . HIS B 2 61  ? 142.846 144.483 160.270 1.00 37.21  ? 61  HIS B CA  1 
ATOM 4558 C C   . HIS B 2 61  ? 141.771 144.924 161.250 1.00 37.21  ? 61  HIS B C   1 
ATOM 4559 O O   . HIS B 2 61  ? 140.938 144.121 161.674 1.00 37.21  ? 61  HIS B O   1 
ATOM 4560 C CB  . HIS B 2 61  ? 142.245 144.203 158.887 1.00 37.21  ? 61  HIS B CB  1 
ATOM 4561 C CG  . HIS B 2 61  ? 141.063 145.054 158.543 1.00 37.21  ? 61  HIS B CG  1 
ATOM 4562 N ND1 . HIS B 2 61  ? 141.157 146.413 158.338 1.00 37.21  ? 61  HIS B ND1 1 
ATOM 4563 C CD2 . HIS B 2 61  ? 139.764 144.733 158.341 1.00 37.21  ? 61  HIS B CD2 1 
ATOM 4564 C CE1 . HIS B 2 61  ? 139.965 146.893 158.034 1.00 37.21  ? 61  HIS B CE1 1 
ATOM 4565 N NE2 . HIS B 2 61  ? 139.102 145.894 158.029 1.00 37.21  ? 61  HIS B NE2 1 
ATOM 4566 N N   . THR B 2 62  ? 141.806 146.204 161.617 1.00 39.03  ? 62  THR B N   1 
ATOM 4567 C CA  . THR B 2 62  ? 140.895 146.780 162.597 1.00 39.03  ? 62  THR B CA  1 
ATOM 4568 C C   . THR B 2 62  ? 140.078 147.879 161.936 1.00 39.03  ? 62  THR B C   1 
ATOM 4569 O O   . THR B 2 62  ? 140.642 148.773 161.299 1.00 39.03  ? 62  THR B O   1 
ATOM 4570 C CB  . THR B 2 62  ? 141.655 147.367 163.794 1.00 39.03  ? 62  THR B CB  1 
ATOM 4571 O OG1 . THR B 2 62  ? 142.182 148.649 163.440 1.00 39.03  ? 62  THR B OG1 1 
ATOM 4572 C CG2 . THR B 2 62  ? 142.808 146.477 164.203 1.00 39.03  ? 62  THR B CG2 1 
ATOM 4573 N N   . GLU B 2 63  ? 138.759 147.823 162.096 1.00 39.03  ? 63  GLU B N   1 
ATOM 4574 C CA  . GLU B 2 63  ? 137.867 148.876 161.627 1.00 39.03  ? 63  GLU B CA  1 
ATOM 4575 C C   . GLU B 2 63  ? 137.370 149.676 162.820 1.00 39.03  ? 63  GLU B C   1 
ATOM 4576 O O   . GLU B 2 63  ? 136.908 149.100 163.809 1.00 39.03  ? 63  GLU B O   1 
ATOM 4577 C CB  . GLU B 2 63  ? 136.678 148.303 160.857 1.00 39.03  ? 63  GLU B CB  1 
ATOM 4578 C CG  . GLU B 2 63  ? 136.940 148.061 159.389 1.00 39.03  ? 63  GLU B CG  1 
ATOM 4579 C CD  . GLU B 2 63  ? 136.701 149.289 158.537 1.00 39.03  ? 63  GLU B CD  1 
ATOM 4580 O OE1 . GLU B 2 63  ? 135.641 149.928 158.695 1.00 39.03  ? 63  GLU B OE1 1 
ATOM 4581 O OE2 . GLU B 2 63  ? 137.572 149.613 157.704 1.00 39.03  ? 63  GLU B OE2 1 
ATOM 4582 N N   . TYR B 2 64  ? 137.490 150.997 162.740 1.00 42.17  ? 64  TYR B N   1 
ATOM 4583 C CA  . TYR B 2 64  ? 137.121 151.895 163.825 1.00 42.17  ? 64  TYR B CA  1 
ATOM 4584 C C   . TYR B 2 64  ? 136.069 152.870 163.318 1.00 42.17  ? 64  TYR B C   1 
ATOM 4585 O O   . TYR B 2 64  ? 136.051 153.210 162.131 1.00 42.17  ? 64  TYR B O   1 
ATOM 4586 C CB  . TYR B 2 64  ? 138.328 152.688 164.349 1.00 42.17  ? 64  TYR B CB  1 
ATOM 4587 C CG  . TYR B 2 64  ? 139.283 151.961 165.282 1.00 42.17  ? 64  TYR B CG  1 
ATOM 4588 C CD1 . TYR B 2 64  ? 139.473 150.595 165.194 1.00 42.17  ? 64  TYR B CD1 1 
ATOM 4589 C CD2 . TYR B 2 64  ? 140.018 152.655 166.232 1.00 42.17  ? 64  TYR B CD2 1 
ATOM 4590 C CE1 . TYR B 2 64  ? 140.335 149.936 166.010 1.00 42.17  ? 64  TYR B CE1 1 
ATOM 4591 C CE2 . TYR B 2 64  ? 140.900 151.991 167.067 1.00 42.17  ? 64  TYR B CE2 1 
ATOM 4592 C CZ  . TYR B 2 64  ? 141.045 150.625 166.943 1.00 42.17  ? 64  TYR B CZ  1 
ATOM 4593 O OH  . TYR B 2 64  ? 141.903 149.907 167.734 1.00 42.17  ? 64  TYR B OH  1 
ATOM 4594 N N   . ALA B 2 65  ? 135.194 153.320 164.210 1.00 45.36  ? 65  ALA B N   1 
ATOM 4595 C CA  . ALA B 2 65  ? 134.205 154.314 163.826 1.00 45.36  ? 65  ALA B CA  1 
ATOM 4596 C C   . ALA B 2 65  ? 134.837 155.695 163.739 1.00 45.36  ? 65  ALA B C   1 
ATOM 4597 O O   . ALA B 2 65  ? 135.885 155.962 164.328 1.00 45.36  ? 65  ALA B O   1 
ATOM 4598 C CB  . ALA B 2 65  ? 133.050 154.346 164.821 1.00 45.36  ? 65  ALA B CB  1 
ATOM 4599 N N   . ASP B 2 66  ? 134.184 156.580 162.988 1.00 52.72  ? 66  ASP B N   1 
ATOM 4600 C CA  . ASP B 2 66  ? 134.659 157.954 162.891 1.00 52.72  ? 66  ASP B CA  1 
ATOM 4601 C C   . ASP B 2 66  ? 134.279 158.783 164.108 1.00 52.72  ? 66  ASP B C   1 
ATOM 4602 O O   . ASP B 2 66  ? 134.774 159.906 164.252 1.00 52.72  ? 66  ASP B O   1 
ATOM 4603 C CB  . ASP B 2 66  ? 134.118 158.611 161.623 1.00 52.72  ? 66  ASP B CB  1 
ATOM 4604 C CG  . ASP B 2 66  ? 134.901 158.223 160.391 1.00 52.72  ? 66  ASP B CG  1 
ATOM 4605 O OD1 . ASP B 2 66  ? 135.652 157.228 160.454 1.00 52.72  ? 66  ASP B OD1 1 
ATOM 4606 O OD2 . ASP B 2 66  ? 134.764 158.911 159.358 1.00 52.72  ? 66  ASP B OD2 1 
ATOM 4607 N N   . SER B 2 67  ? 133.398 158.268 164.970 1.00 49.85  ? 67  SER B N   1 
ATOM 4608 C CA  . SER B 2 67  ? 133.066 158.976 166.200 1.00 49.85  ? 67  SER B CA  1 
ATOM 4609 C C   . SER B 2 67  ? 134.251 158.998 167.153 1.00 49.85  ? 67  SER B C   1 
ATOM 4610 O O   . SER B 2 67  ? 134.607 160.054 167.690 1.00 49.85  ? 67  SER B O   1 
ATOM 4611 C CB  . SER B 2 67  ? 131.854 158.328 166.866 1.00 49.85  ? 67  SER B CB  1 
ATOM 4612 O OG  . SER B 2 67  ? 130.741 158.319 165.990 1.00 49.85  ? 67  SER B OG  1 
ATOM 4613 N N   . VAL B 2 68  ? 134.882 157.847 167.366 1.00 50.73  ? 68  VAL B N   1 
ATOM 4614 C CA  . VAL B 2 68  ? 136.112 157.741 168.146 1.00 50.73  ? 68  VAL B CA  1 
ATOM 4615 C C   . VAL B 2 68  ? 137.199 157.126 167.260 1.00 50.73  ? 68  VAL B C   1 
ATOM 4616 O O   . VAL B 2 68  ? 137.176 155.931 166.943 1.00 50.73  ? 68  VAL B O   1 
ATOM 4617 C CB  . VAL B 2 68  ? 135.911 156.984 169.472 1.00 50.73  ? 68  VAL B CB  1 
ATOM 4618 C CG1 . VAL B 2 68  ? 135.043 157.812 170.385 1.00 50.73  ? 68  VAL B CG1 1 
ATOM 4619 C CG2 . VAL B 2 68  ? 135.140 155.676 169.293 1.00 50.73  ? 68  VAL B CG2 1 
ATOM 4620 N N   . LYS B 2 69  ? 138.132 157.961 166.813 1.00 51.69  ? 69  LYS B N   1 
ATOM 4621 C CA  . LYS B 2 69  ? 139.183 157.545 165.894 1.00 51.69  ? 69  LYS B CA  1 
ATOM 4622 C C   . LYS B 2 69  ? 140.522 157.980 166.466 1.00 51.69  ? 69  LYS B C   1 
ATOM 4623 O O   . LYS B 2 69  ? 140.810 159.179 166.538 1.00 51.69  ? 69  LYS B O   1 
ATOM 4624 C CB  . LYS B 2 69  ? 138.963 158.143 164.500 1.00 51.69  ? 69  LYS B CB  1 
ATOM 4625 C CG  . LYS B 2 69  ? 139.801 157.511 163.399 1.00 51.69  ? 69  LYS B CG  1 
ATOM 4626 C CD  . LYS B 2 69  ? 139.631 156.005 163.369 1.00 51.69  ? 69  LYS B CD  1 
ATOM 4627 C CE  . LYS B 2 69  ? 140.265 155.394 162.130 1.00 51.69  ? 69  LYS B CE  1 
ATOM 4628 N NZ  . LYS B 2 69  ? 139.319 155.343 160.980 1.00 51.69  ? 69  LYS B NZ  1 
ATOM 4629 N N   . GLY B 2 70  ? 141.335 157.008 166.872 1.00 52.15  ? 70  GLY B N   1 
ATOM 4630 C CA  . GLY B 2 70  ? 142.616 157.274 167.477 1.00 52.15  ? 70  GLY B CA  1 
ATOM 4631 C C   . GLY B 2 70  ? 142.594 157.375 168.985 1.00 52.15  ? 70  GLY B C   1 
ATOM 4632 O O   . GLY B 2 70  ? 143.647 157.242 169.617 1.00 52.15  ? 70  GLY B O   1 
ATOM 4633 N N   . ARG B 2 71  ? 141.425 157.603 169.579 1.00 54.45  ? 71  ARG B N   1 
ATOM 4634 C CA  . ARG B 2 71  ? 141.279 157.605 171.028 1.00 54.45  ? 71  ARG B CA  1 
ATOM 4635 C C   . ARG B 2 71  ? 141.026 156.201 171.559 1.00 54.45  ? 71  ARG B C   1 
ATOM 4636 O O   . ARG B 2 71  ? 141.467 155.858 172.659 1.00 54.45  ? 71  ARG B O   1 
ATOM 4637 C CB  . ARG B 2 71  ? 140.137 158.534 171.440 1.00 54.45  ? 71  ARG B CB  1 
ATOM 4638 C CG  . ARG B 2 71  ? 139.914 159.697 170.497 1.00 54.45  ? 71  ARG B CG  1 
ATOM 4639 C CD  . ARG B 2 71  ? 138.981 160.705 171.127 1.00 54.45  ? 71  ARG B CD  1 
ATOM 4640 N NE  . ARG B 2 71  ? 137.767 160.064 171.614 1.00 54.45  ? 71  ARG B NE  1 
ATOM 4641 C CZ  . ARG B 2 71  ? 137.076 160.475 172.667 1.00 54.45  ? 71  ARG B CZ  1 
ATOM 4642 N NH1 . ARG B 2 71  ? 137.451 161.529 173.370 1.00 54.45  ? 71  ARG B NH1 1 
ATOM 4643 N NH2 . ARG B 2 71  ? 135.982 159.810 173.024 1.00 54.45  ? 71  ARG B NH2 1 
ATOM 4644 N N   . PHE B 2 72  ? 140.316 155.387 170.788 1.00 48.88  ? 72  PHE B N   1 
ATOM 4645 C CA  . PHE B 2 72  ? 140.021 154.021 171.179 1.00 48.88  ? 72  PHE B CA  1 
ATOM 4646 C C   . PHE B 2 72  ? 141.090 153.086 170.627 1.00 48.88  ? 72  PHE B C   1 
ATOM 4647 O O   . PHE B 2 72  ? 141.864 153.445 169.738 1.00 48.88  ? 72  PHE B O   1 
ATOM 4648 C CB  . PHE B 2 72  ? 138.637 153.601 170.680 1.00 48.88  ? 72  PHE B CB  1 
ATOM 4649 C CG  . PHE B 2 72  ? 137.491 154.028 171.573 1.00 48.88  ? 72  PHE B CG  1 
ATOM 4650 C CD1 . PHE B 2 72  ? 137.497 155.249 172.228 1.00 48.88  ? 72  PHE B CD1 1 
ATOM 4651 C CD2 . PHE B 2 72  ? 136.388 153.209 171.726 1.00 48.88  ? 72  PHE B CD2 1 
ATOM 4652 C CE1 . PHE B 2 72  ? 136.445 155.630 173.026 1.00 48.88  ? 72  PHE B CE1 1 
ATOM 4653 C CE2 . PHE B 2 72  ? 135.330 153.589 172.523 1.00 48.88  ? 72  PHE B CE2 1 
ATOM 4654 C CZ  . PHE B 2 72  ? 135.359 154.802 173.171 1.00 48.88  ? 72  PHE B CZ  1 
ATOM 4655 N N   . THR B 2 73  ? 141.140 151.876 171.182 1.00 47.01  ? 73  THR B N   1 
ATOM 4656 C CA  . THR B 2 73  ? 142.147 150.891 170.788 1.00 47.01  ? 73  THR B CA  1 
ATOM 4657 C C   . THR B 2 73  ? 141.537 149.508 170.987 1.00 47.01  ? 73  THR B C   1 
ATOM 4658 O O   . THR B 2 73  ? 141.360 149.073 172.125 1.00 47.01  ? 73  THR B O   1 
ATOM 4659 C CB  . THR B 2 73  ? 143.432 151.047 171.593 1.00 47.01  ? 73  THR B CB  1 
ATOM 4660 O OG1 . THR B 2 73  ? 144.011 152.334 171.353 1.00 47.01  ? 73  THR B OG1 1 
ATOM 4661 C CG2 . THR B 2 73  ? 144.435 149.978 171.200 1.00 47.01  ? 73  THR B CG2 1 
ATOM 4662 N N   . ILE B 2 74  ? 141.225 148.824 169.905 1.00 40.23  ? 74  ILE B N   1 
ATOM 4663 C CA  . ILE B 2 74  ? 140.697 147.472 170.035 1.00 40.23  ? 74  ILE B CA  1 
ATOM 4664 C C   . ILE B 2 74  ? 141.856 146.489 169.939 1.00 40.23  ? 74  ILE B C   1 
ATOM 4665 O O   . ILE B 2 74  ? 142.905 146.782 169.355 1.00 40.23  ? 74  ILE B O   1 
ATOM 4666 C CB  . ILE B 2 74  ? 139.587 147.189 168.995 1.00 40.23  ? 74  ILE B CB  1 
ATOM 4667 C CG1 . ILE B 2 74  ? 138.624 146.123 169.518 1.00 40.23  ? 74  ILE B CG1 1 
ATOM 4668 C CG2 . ILE B 2 74  ? 140.151 146.754 167.662 1.00 40.23  ? 74  ILE B CG2 1 
ATOM 4669 C CD1 . ILE B 2 74  ? 137.435 145.876 168.626 1.00 40.23  ? 74  ILE B CD1 1 
ATOM 4670 N N   . SER B 2 75  ? 141.693 145.329 170.570 1.00 40.92  ? 75  SER B N   1 
ATOM 4671 C CA  . SER B 2 75  ? 142.747 144.327 170.594 1.00 40.92  ? 75  SER B CA  1 
ATOM 4672 C C   . SER B 2 75  ? 142.123 142.958 170.809 1.00 40.92  ? 75  SER B C   1 
ATOM 4673 O O   . SER B 2 75  ? 141.007 142.839 171.314 1.00 40.92  ? 75  SER B O   1 
ATOM 4674 C CB  . SER B 2 75  ? 143.776 144.621 171.691 1.00 40.92  ? 75  SER B CB  1 
ATOM 4675 O OG  . SER B 2 75  ? 143.375 144.057 172.926 1.00 40.92  ? 75  SER B OG  1 
ATOM 4676 N N   . ARG B 2 76  ? 142.868 141.922 170.444 1.00 39.50  ? 76  ARG B N   1 
ATOM 4677 C CA  . ARG B 2 76  ? 142.376 140.558 170.528 1.00 39.50  ? 76  ARG B CA  1 
ATOM 4678 C C   . ARG B 2 76  ? 143.450 139.669 171.140 1.00 39.50  ? 76  ARG B C   1 
ATOM 4679 O O   . ARG B 2 76  ? 144.646 139.881 170.927 1.00 39.50  ? 76  ARG B O   1 
ATOM 4680 C CB  . ARG B 2 76  ? 141.967 140.040 169.140 1.00 39.50  ? 76  ARG B CB  1 
ATOM 4681 C CG  . ARG B 2 76  ? 141.124 138.782 169.146 1.00 39.50  ? 76  ARG B CG  1 
ATOM 4682 C CD  . ARG B 2 76  ? 140.282 138.681 167.894 1.00 39.50  ? 76  ARG B CD  1 
ATOM 4683 N NE  . ARG B 2 76  ? 139.305 137.605 167.986 1.00 39.50  ? 76  ARG B NE  1 
ATOM 4684 C CZ  . ARG B 2 76  ? 138.402 137.331 167.055 1.00 39.50  ? 76  ARG B CZ  1 
ATOM 4685 N NH1 . ARG B 2 76  ? 138.328 138.033 165.939 1.00 39.50  ? 76  ARG B NH1 1 
ATOM 4686 N NH2 . ARG B 2 76  ? 137.554 136.328 167.247 1.00 39.50  ? 76  ARG B NH2 1 
ATOM 4687 N N   . ASP B 2 77  ? 143.011 138.678 171.917 1.00 46.43  ? 77  ASP B N   1 
ATOM 4688 C CA  . ASP B 2 77  ? 143.899 137.645 172.444 1.00 46.43  ? 77  ASP B CA  1 
ATOM 4689 C C   . ASP B 2 77  ? 143.164 136.320 172.264 1.00 46.43  ? 77  ASP B C   1 
ATOM 4690 O O   . ASP B 2 77  ? 142.260 135.999 173.040 1.00 46.43  ? 77  ASP B O   1 
ATOM 4691 C CB  . ASP B 2 77  ? 144.252 137.904 173.901 1.00 46.43  ? 77  ASP B CB  1 
ATOM 4692 C CG  . ASP B 2 77  ? 145.470 137.122 174.359 1.00 46.43  ? 77  ASP B CG  1 
ATOM 4693 O OD1 . ASP B 2 77  ? 146.022 136.339 173.558 1.00 46.43  ? 77  ASP B OD1 1 
ATOM 4694 O OD2 . ASP B 2 77  ? 145.882 137.296 175.525 1.00 46.43  ? 77  ASP B OD2 1 
ATOM 4695 N N   . ASN B 2 78  ? 143.548 135.569 171.233 1.00 46.19  ? 78  ASN B N   1 
ATOM 4696 C CA  . ASN B 2 78  ? 142.828 134.355 170.882 1.00 46.19  ? 78  ASN B CA  1 
ATOM 4697 C C   . ASN B 2 78  ? 143.203 133.162 171.749 1.00 46.19  ? 78  ASN B C   1 
ATOM 4698 O O   . ASN B 2 78  ? 142.479 132.162 171.738 1.00 46.19  ? 78  ASN B O   1 
ATOM 4699 C CB  . ASN B 2 78  ? 143.065 134.012 169.412 1.00 46.19  ? 78  ASN B CB  1 
ATOM 4700 C CG  . ASN B 2 78  ? 141.960 134.518 168.514 1.00 46.19  ? 78  ASN B CG  1 
ATOM 4701 O OD1 . ASN B 2 78  ? 140.781 134.256 168.753 1.00 46.19  ? 78  ASN B OD1 1 
ATOM 4702 N ND2 . ASN B 2 78  ? 142.333 135.244 167.468 1.00 46.19  ? 78  ASN B ND2 1 
ATOM 4703 N N   . ALA B 2 79  ? 144.316 133.237 172.483 1.00 48.77  ? 79  ALA B N   1 
ATOM 4704 C CA  . ALA B 2 79  ? 144.687 132.144 173.376 1.00 48.77  ? 79  ALA B CA  1 
ATOM 4705 C C   . ALA B 2 79  ? 143.731 132.052 174.559 1.00 48.77  ? 79  ALA B C   1 
ATOM 4706 O O   . ALA B 2 79  ? 143.308 130.955 174.942 1.00 48.77  ? 79  ALA B O   1 
ATOM 4707 C CB  . ALA B 2 79  ? 146.125 132.322 173.860 1.00 48.77  ? 79  ALA B CB  1 
ATOM 4708 N N   . LYS B 2 80  ? 143.380 133.193 175.148 1.00 48.96  ? 80  LYS B N   1 
ATOM 4709 C CA  . LYS B 2 80  ? 142.373 133.255 176.195 1.00 48.96  ? 80  LYS B CA  1 
ATOM 4710 C C   . LYS B 2 80  ? 140.990 133.572 175.649 1.00 48.96  ? 80  LYS B C   1 
ATOM 4711 O O   . LYS B 2 80  ? 140.040 133.666 176.434 1.00 48.96  ? 80  LYS B O   1 
ATOM 4712 C CB  . LYS B 2 80  ? 142.769 134.290 177.249 1.00 48.96  ? 80  LYS B CB  1 
ATOM 4713 C CG  . LYS B 2 80  ? 143.145 135.639 176.681 1.00 48.96  ? 80  LYS B CG  1 
ATOM 4714 C CD  . LYS B 2 80  ? 143.260 136.672 177.784 1.00 48.96  ? 80  LYS B CD  1 
ATOM 4715 C CE  . LYS B 2 80  ? 144.562 136.512 178.551 1.00 48.96  ? 80  LYS B CE  1 
ATOM 4716 N NZ  . LYS B 2 80  ? 145.132 137.825 178.961 1.00 48.96  ? 80  LYS B NZ  1 
ATOM 4717 N N   . ASN B 2 81  ? 140.879 133.752 174.329 1.00 47.16  ? 81  ASN B N   1 
ATOM 4718 C CA  . ASN B 2 81  ? 139.625 133.906 173.585 1.00 47.16  ? 81  ASN B CA  1 
ATOM 4719 C C   . ASN B 2 81  ? 138.839 135.134 174.057 1.00 47.16  ? 81  ASN B C   1 
ATOM 4720 O O   . ASN B 2 81  ? 137.691 135.049 174.493 1.00 47.16  ? 81  ASN B O   1 
ATOM 4721 C CB  . ASN B 2 81  ? 138.778 132.633 173.669 1.00 47.16  ? 81  ASN B CB  1 
ATOM 4722 C CG  . ASN B 2 81  ? 138.041 132.357 172.390 1.00 47.16  ? 81  ASN B CG  1 
ATOM 4723 O OD1 . ASN B 2 81  ? 138.344 132.954 171.360 1.00 47.16  ? 81  ASN B OD1 1 
ATOM 4724 N ND2 . ASN B 2 81  ? 137.068 131.457 172.439 1.00 47.16  ? 81  ASN B ND2 1 
ATOM 4725 N N   . THR B 2 82  ? 139.493 136.288 173.954 1.00 45.71  ? 82  THR B N   1 
ATOM 4726 C CA  . THR B 2 82  ? 139.000 137.535 174.519 1.00 45.71  ? 82  THR B CA  1 
ATOM 4727 C C   . THR B 2 82  ? 139.297 138.662 173.538 1.00 45.71  ? 82  THR B C   1 
ATOM 4728 O O   . THR B 2 82  ? 140.264 138.593 172.779 1.00 45.71  ? 82  THR B O   1 
ATOM 4729 C CB  . THR B 2 82  ? 139.671 137.797 175.889 1.00 45.71  ? 82  THR B CB  1 
ATOM 4730 O OG1 . THR B 2 82  ? 139.627 136.604 176.680 1.00 45.71  ? 82  THR B OG1 1 
ATOM 4731 C CG2 . THR B 2 82  ? 138.986 138.899 176.674 1.00 45.71  ? 82  THR B CG2 1 
ATOM 4732 N N   . VAL B 2 83  ? 138.446 139.686 173.522 1.00 44.17  ? 83  VAL B N   1 
ATOM 4733 C CA  . VAL B 2 83  ? 138.812 140.967 172.922 1.00 44.17  ? 83  VAL B CA  1 
ATOM 4734 C C   . VAL B 2 83  ? 138.764 142.048 173.983 1.00 44.17  ? 83  VAL B C   1 
ATOM 4735 O O   . VAL B 2 83  ? 138.066 141.913 174.991 1.00 44.17  ? 83  VAL B O   1 
ATOM 4736 C CB  . VAL B 2 83  ? 137.944 141.366 171.714 1.00 44.17  ? 83  VAL B CB  1 
ATOM 4737 C CG1 . VAL B 2 83  ? 138.105 140.372 170.605 1.00 44.17  ? 83  VAL B CG1 1 
ATOM 4738 C CG2 . VAL B 2 83  ? 136.489 141.494 172.110 1.00 44.17  ? 83  VAL B CG2 1 
ATOM 4739 N N   . TYR B 2 84  ? 139.542 143.097 173.769 1.00 43.97  ? 84  TYR B N   1 
ATOM 4740 C CA  . TYR B 2 84  ? 139.645 144.218 174.681 1.00 43.97  ? 84  TYR B CA  1 
ATOM 4741 C C   . TYR B 2 84  ? 139.427 145.508 173.908 1.00 43.97  ? 84  TYR B C   1 
ATOM 4742 O O   . TYR B 2 84  ? 139.721 145.595 172.712 1.00 43.97  ? 84  TYR B O   1 
ATOM 4743 C CB  . TYR B 2 84  ? 141.013 144.256 175.372 1.00 43.97  ? 84  TYR B CB  1 
ATOM 4744 C CG  . TYR B 2 84  ? 141.332 143.043 176.215 1.00 43.97  ? 84  TYR B CG  1 
ATOM 4745 C CD1 . TYR B 2 84  ? 141.928 141.918 175.653 1.00 43.97  ? 84  TYR B CD1 1 
ATOM 4746 C CD2 . TYR B 2 84  ? 141.042 143.023 177.570 1.00 43.97  ? 84  TYR B CD2 1 
ATOM 4747 C CE1 . TYR B 2 84  ? 142.224 140.810 176.419 1.00 43.97  ? 84  TYR B CE1 1 
ATOM 4748 C CE2 . TYR B 2 84  ? 141.338 141.921 178.344 1.00 43.97  ? 84  TYR B CE2 1 
ATOM 4749 C CZ  . TYR B 2 84  ? 141.924 140.819 177.764 1.00 43.97  ? 84  TYR B CZ  1 
ATOM 4750 O OH  . TYR B 2 84  ? 142.213 139.724 178.542 1.00 43.97  ? 84  TYR B OH  1 
ATOM 4751 N N   . LEU B 2 85  ? 138.903 146.506 174.605 1.00 42.51  ? 85  LEU B N   1 
ATOM 4752 C CA  . LEU B 2 85  ? 138.716 147.842 174.053 1.00 42.51  ? 85  LEU B CA  1 
ATOM 4753 C C   . LEU B 2 85  ? 139.265 148.820 175.085 1.00 42.51  ? 85  LEU B C   1 
ATOM 4754 O O   . LEU B 2 85  ? 138.642 149.045 176.127 1.00 42.51  ? 85  LEU B O   1 
ATOM 4755 C CB  . LEU B 2 85  ? 137.250 148.101 173.732 1.00 42.51  ? 85  LEU B CB  1 
ATOM 4756 C CG  . LEU B 2 85  ? 136.834 149.502 173.301 1.00 42.51  ? 85  LEU B CG  1 
ATOM 4757 C CD1 . LEU B 2 85  ? 137.090 149.663 171.820 1.00 42.51  ? 85  LEU B CD1 1 
ATOM 4758 C CD2 . LEU B 2 85  ? 135.369 149.703 173.603 1.00 42.51  ? 85  LEU B CD2 1 
ATOM 4759 N N   . GLN B 2 86  ? 140.463 149.332 174.817 1.00 48.20  ? 86  GLN B N   1 
ATOM 4760 C CA  . GLN B 2 86  ? 141.067 150.394 175.607 1.00 48.20  ? 86  GLN B CA  1 
ATOM 4761 C C   . GLN B 2 86  ? 140.508 151.731 175.154 1.00 48.20  ? 86  GLN B C   1 
ATOM 4762 O O   . GLN B 2 86  ? 140.465 152.021 173.958 1.00 48.20  ? 86  GLN B O   1 
ATOM 4763 C CB  . GLN B 2 86  ? 142.586 150.383 175.438 1.00 48.20  ? 86  GLN B CB  1 
ATOM 4764 C CG  . GLN B 2 86  ? 143.330 151.342 176.346 1.00 48.20  ? 86  GLN B CG  1 
ATOM 4765 C CD  . GLN B 2 86  ? 143.152 151.014 177.807 1.00 48.20  ? 86  GLN B CD  1 
ATOM 4766 O OE1 . GLN B 2 86  ? 143.231 149.855 178.203 1.00 48.20  ? 86  GLN B OE1 1 
ATOM 4767 N NE2 . GLN B 2 86  ? 142.914 152.034 178.620 1.00 48.20  ? 86  GLN B NE2 1 
ATOM 4768 N N   . MET B 2 87  ? 140.079 152.547 176.105 1.00 51.65  ? 87  MET B N   1 
ATOM 4769 C CA  . MET B 2 87  ? 139.445 153.820 175.816 1.00 51.65  ? 87  MET B CA  1 
ATOM 4770 C C   . MET B 2 87  ? 140.201 154.908 176.558 1.00 51.65  ? 87  MET B C   1 
ATOM 4771 O O   . MET B 2 87  ? 140.357 154.829 177.780 1.00 51.65  ? 87  MET B O   1 
ATOM 4772 C CB  . MET B 2 87  ? 137.978 153.783 176.237 1.00 51.65  ? 87  MET B CB  1 
ATOM 4773 C CG  . MET B 2 87  ? 137.191 152.745 175.468 1.00 51.65  ? 87  MET B CG  1 
ATOM 4774 S SD  . MET B 2 87  ? 135.729 152.135 176.308 1.00 51.65  ? 87  MET B SD  1 
ATOM 4775 C CE  . MET B 2 87  ? 134.959 153.664 176.771 1.00 51.65  ? 87  MET B CE  1 
ATOM 4776 N N   . ASN B 2 88  ? 140.675 155.910 175.823 1.00 55.65  ? 88  ASN B N   1 
ATOM 4777 C CA  . ASN B 2 88  ? 141.517 156.950 176.391 1.00 55.65  ? 88  ASN B CA  1 
ATOM 4778 C C   . ASN B 2 88  ? 140.977 158.314 175.997 1.00 55.65  ? 88  ASN B C   1 
ATOM 4779 O O   . ASN B 2 88  ? 140.439 158.476 174.897 1.00 55.65  ? 88  ASN B O   1 
ATOM 4780 C CB  . ASN B 2 88  ? 142.972 156.815 175.923 1.00 55.65  ? 88  ASN B CB  1 
ATOM 4781 C CG  . ASN B 2 88  ? 143.467 155.386 175.960 1.00 55.65  ? 88  ASN B CG  1 
ATOM 4782 O OD1 . ASN B 2 88  ? 143.404 154.724 176.993 1.00 55.65  ? 88  ASN B OD1 1 
ATOM 4783 N ND2 . ASN B 2 88  ? 143.965 154.904 174.830 1.00 55.65  ? 88  ASN B ND2 1 
ATOM 4784 N N   . SER B 2 89  ? 141.148 159.285 176.904 1.00 60.06  ? 89  SER B N   1 
ATOM 4785 C CA  . SER B 2 89  ? 140.703 160.676 176.753 1.00 60.06  ? 89  SER B CA  1 
ATOM 4786 C C   . SER B 2 89  ? 139.202 160.745 176.464 1.00 60.06  ? 89  SER B C   1 
ATOM 4787 O O   . SER B 2 89  ? 138.760 161.210 175.412 1.00 60.06  ? 89  SER B O   1 
ATOM 4788 C CB  . SER B 2 89  ? 141.515 161.416 175.680 1.00 60.06  ? 89  SER B CB  1 
ATOM 4789 O OG  . SER B 2 89  ? 141.182 160.970 174.376 1.00 60.06  ? 89  SER B OG  1 
ATOM 4790 N N   . LEU B 2 90  ? 138.426 160.255 177.424 1.00 59.39  ? 90  LEU B N   1 
ATOM 4791 C CA  . LEU B 2 90  ? 137.000 160.081 177.215 1.00 59.39  ? 90  LEU B CA  1 
ATOM 4792 C C   . LEU B 2 90  ? 136.256 161.409 177.281 1.00 59.39  ? 90  LEU B C   1 
ATOM 4793 O O   . LEU B 2 90  ? 136.694 162.379 177.905 1.00 59.39  ? 90  LEU B O   1 
ATOM 4794 C CB  . LEU B 2 90  ? 136.421 159.111 178.239 1.00 59.39  ? 90  LEU B CB  1 
ATOM 4795 C CG  . LEU B 2 90  ? 136.854 157.677 177.958 1.00 59.39  ? 90  LEU B CG  1 
ATOM 4796 C CD1 . LEU B 2 90  ? 136.748 156.800 179.190 1.00 59.39  ? 90  LEU B CD1 1 
ATOM 4797 C CD2 . LEU B 2 90  ? 136.045 157.139 176.811 1.00 59.39  ? 90  LEU B CD2 1 
ATOM 4798 N N   . LYS B 2 91  ? 135.108 161.433 176.620 1.00 59.64  ? 91  LYS B N   1 
ATOM 4799 C CA  . LYS B 2 91  ? 134.177 162.545 176.604 1.00 59.64  ? 91  LYS B CA  1 
ATOM 4800 C C   . LYS B 2 91  ? 132.879 162.112 177.270 1.00 59.64  ? 91  LYS B C   1 
ATOM 4801 O O   . LYS B 2 91  ? 132.590 160.912 177.352 1.00 59.64  ? 91  LYS B O   1 
ATOM 4802 C CB  . LYS B 2 91  ? 133.900 163.005 175.164 1.00 59.64  ? 91  LYS B CB  1 
ATOM 4803 C CG  . LYS B 2 91  ? 135.068 163.699 174.491 1.00 59.64  ? 91  LYS B CG  1 
ATOM 4804 C CD  . LYS B 2 91  ? 134.601 164.486 173.277 1.00 59.64  ? 91  LYS B CD  1 
ATOM 4805 C CE  . LYS B 2 91  ? 134.194 163.572 172.134 1.00 59.64  ? 91  LYS B CE  1 
ATOM 4806 N NZ  . LYS B 2 91  ? 135.369 162.926 171.490 1.00 59.64  ? 91  LYS B NZ  1 
ATOM 4807 N N   . PRO B 2 92  ? 132.082 163.056 177.783 1.00 62.37  ? 92  PRO B N   1 
ATOM 4808 C CA  . PRO B 2 92  ? 130.749 162.687 178.290 1.00 62.37  ? 92  PRO B CA  1 
ATOM 4809 C C   . PRO B 2 92  ? 129.801 162.173 177.218 1.00 62.37  ? 92  PRO B C   1 
ATOM 4810 O O   . PRO B 2 92  ? 128.816 161.506 177.556 1.00 62.37  ? 92  PRO B O   1 
ATOM 4811 C CB  . PRO B 2 92  ? 130.235 163.991 178.912 1.00 62.37  ? 92  PRO B CB  1 
ATOM 4812 C CG  . PRO B 2 92  ? 131.456 164.762 179.231 1.00 62.37  ? 92  PRO B CG  1 
ATOM 4813 C CD  . PRO B 2 92  ? 132.449 164.430 178.166 1.00 62.37  ? 92  PRO B CD  1 
ATOM 4814 N N   . GLU B 2 93  ? 130.071 162.450 175.937 1.00 62.48  ? 93  GLU B N   1 
ATOM 4815 C CA  . GLU B 2 93  ? 129.272 161.892 174.852 1.00 62.48  ? 93  GLU B CA  1 
ATOM 4816 C C   . GLU B 2 93  ? 129.513 160.400 174.655 1.00 62.48  ? 93  GLU B C   1 
ATOM 4817 O O   . GLU B 2 93  ? 128.739 159.747 173.949 1.00 62.48  ? 93  GLU B O   1 
ATOM 4818 C CB  . GLU B 2 93  ? 129.565 162.637 173.549 1.00 62.48  ? 93  GLU B CB  1 
ATOM 4819 C CG  . GLU B 2 93  ? 128.935 164.017 173.462 1.00 62.48  ? 93  GLU B CG  1 
ATOM 4820 C CD  . GLU B 2 93  ? 129.803 165.100 174.075 1.00 62.48  ? 93  GLU B CD  1 
ATOM 4821 O OE1 . GLU B 2 93  ? 130.916 164.783 174.546 1.00 62.48  ? 93  GLU B OE1 1 
ATOM 4822 O OE2 . GLU B 2 93  ? 129.372 166.273 174.085 1.00 62.48  ? 93  GLU B OE2 1 
ATOM 4823 N N   . ASP B 2 94  ? 130.567 159.849 175.254 1.00 58.07  ? 94  ASP B N   1 
ATOM 4824 C CA  . ASP B 2 94  ? 130.846 158.423 175.179 1.00 58.07  ? 94  ASP B CA  1 
ATOM 4825 C C   . ASP B 2 94  ? 130.064 157.612 176.201 1.00 58.07  ? 94  ASP B C   1 
ATOM 4826 O O   . ASP B 2 94  ? 130.220 156.387 176.233 1.00 58.07  ? 94  ASP B O   1 
ATOM 4827 C CB  . ASP B 2 94  ? 132.344 158.165 175.371 1.00 58.07  ? 94  ASP B CB  1 
ATOM 4828 C CG  . ASP B 2 94  ? 133.203 159.025 174.473 1.00 58.07  ? 94  ASP B CG  1 
ATOM 4829 O OD1 . ASP B 2 94  ? 132.707 159.469 173.418 1.00 58.07  ? 94  ASP B OD1 1 
ATOM 4830 O OD2 . ASP B 2 94  ? 134.378 159.258 174.821 1.00 58.07  ? 94  ASP B OD2 1 
ATOM 4831 N N   . THR B 2 95  ? 129.251 158.264 177.038 1.00 57.25  ? 95  THR B N   1 
ATOM 4832 C CA  . THR B 2 95  ? 128.468 157.587 178.066 1.00 57.25  ? 95  THR B CA  1 
ATOM 4833 C C   . THR B 2 95  ? 127.422 156.693 177.417 1.00 57.25  ? 95  THR B C   1 
ATOM 4834 O O   . THR B 2 95  ? 126.433 157.181 176.860 1.00 57.25  ? 95  THR B O   1 
ATOM 4835 C CB  . THR B 2 95  ? 127.798 158.604 178.993 1.00 57.25  ? 95  THR B CB  1 
ATOM 4836 O OG1 . THR B 2 95  ? 128.801 159.365 179.674 1.00 57.25  ? 95  THR B OG1 1 
ATOM 4837 C CG2 . THR B 2 95  ? 126.936 157.900 180.028 1.00 57.25  ? 95  THR B CG2 1 
ATOM 4838 N N   . ALA B 2 96  ? 127.643 155.385 177.474 1.00 52.72  ? 96  ALA B N   1 
ATOM 4839 C CA  . ALA B 2 96  ? 126.837 154.439 176.717 1.00 52.72  ? 96  ALA B CA  1 
ATOM 4840 C C   . ALA B 2 96  ? 126.983 153.065 177.349 1.00 52.72  ? 96  ALA B C   1 
ATOM 4841 O O   . ALA B 2 96  ? 127.884 152.823 178.155 1.00 52.72  ? 96  ALA B O   1 
ATOM 4842 C CB  . ALA B 2 96  ? 127.257 154.403 175.247 1.00 52.72  ? 96  ALA B CB  1 
ATOM 4843 N N   . VAL B 2 97  ? 126.081 152.169 176.974 1.00 47.38  ? 97  VAL B N   1 
ATOM 4844 C CA  . VAL B 2 97  ? 126.191 150.764 177.343 1.00 47.38  ? 97  VAL B CA  1 
ATOM 4845 C C   . VAL B 2 97  ? 126.872 150.030 176.201 1.00 47.38  ? 97  VAL B C   1 
ATOM 4846 O O   . VAL B 2 97  ? 126.350 149.992 175.083 1.00 47.38  ? 97  VAL B O   1 
ATOM 4847 C CB  . VAL B 2 97  ? 124.811 150.160 177.635 1.00 47.38  ? 97  VAL B CB  1 
ATOM 4848 C CG1 . VAL B 2 97  ? 124.956 148.712 178.052 1.00 47.38  ? 97  VAL B CG1 1 
ATOM 4849 C CG2 . VAL B 2 97  ? 124.102 150.963 178.701 1.00 47.38  ? 97  VAL B CG2 1 
ATOM 4850 N N   . TYR B 2 98  ? 128.037 149.453 176.473 1.00 45.05  ? 98  TYR B N   1 
ATOM 4851 C CA  . TYR B 2 98  ? 128.895 148.905 175.431 1.00 45.05  ? 98  TYR B CA  1 
ATOM 4852 C C   . TYR B 2 98  ? 128.645 147.409 175.298 1.00 45.05  ? 98  TYR B C   1 
ATOM 4853 O O   . TYR B 2 98  ? 128.816 146.657 176.262 1.00 45.05  ? 98  TYR B O   1 
ATOM 4854 C CB  . TYR B 2 98  ? 130.365 149.180 175.737 1.00 45.05  ? 98  TYR B CB  1 
ATOM 4855 C CG  . TYR B 2 98  ? 130.814 150.567 175.343 1.00 45.05  ? 98  TYR B CG  1 
ATOM 4856 C CD1 . TYR B 2 98  ? 130.458 151.669 176.102 1.00 45.05  ? 98  TYR B CD1 1 
ATOM 4857 C CD2 . TYR B 2 98  ? 131.567 150.777 174.200 1.00 45.05  ? 98  TYR B CD2 1 
ATOM 4858 C CE1 . TYR B 2 98  ? 130.857 152.935 175.751 1.00 45.05  ? 98  TYR B CE1 1 
ATOM 4859 C CE2 . TYR B 2 98  ? 131.969 152.044 173.836 1.00 45.05  ? 98  TYR B CE2 1 
ATOM 4860 C CZ  . TYR B 2 98  ? 131.611 153.118 174.617 1.00 45.05  ? 98  TYR B CZ  1 
ATOM 4861 O OH  . TYR B 2 98  ? 132.006 154.386 174.262 1.00 45.05  ? 98  TYR B OH  1 
ATOM 4862 N N   . TYR B 2 99  ? 128.252 146.986 174.105 1.00 46.50  ? 99  TYR B N   1 
ATOM 4863 C CA  . TYR B 2 99  ? 127.981 145.589 173.811 1.00 46.50  ? 99  TYR B CA  1 
ATOM 4864 C C   . TYR B 2 99  ? 129.089 144.985 172.964 1.00 46.50  ? 99  TYR B C   1 
ATOM 4865 O O   . TYR B 2 99  ? 129.741 145.664 172.168 1.00 46.50  ? 99  TYR B O   1 
ATOM 4866 C CB  . TYR B 2 99  ? 126.645 145.390 173.085 1.00 46.50  ? 99  TYR B CB  1 
ATOM 4867 C CG  . TYR B 2 99  ? 125.408 145.923 173.776 1.00 46.50  ? 99  TYR B CG  1 
ATOM 4868 C CD1 . TYR B 2 99  ? 125.096 147.277 173.767 1.00 46.50  ? 99  TYR B CD1 1 
ATOM 4869 C CD2 . TYR B 2 99  ? 124.543 145.056 174.434 1.00 46.50  ? 99  TYR B CD2 1 
ATOM 4870 C CE1 . TYR B 2 99  ? 123.966 147.748 174.396 1.00 46.50  ? 99  TYR B CE1 1 
ATOM 4871 C CE2 . TYR B 2 99  ? 123.410 145.521 175.065 1.00 46.50  ? 99  TYR B CE2 1 
ATOM 4872 C CZ  . TYR B 2 99  ? 123.125 146.869 175.041 1.00 46.50  ? 99  TYR B CZ  1 
ATOM 4873 O OH  . TYR B 2 99  ? 121.996 147.342 175.668 1.00 46.50  ? 99  TYR B OH  1 
ATOM 4874 N N   . CYS B 2 100 ? 129.276 143.685 173.145 1.00 46.43  ? 100 CYS B N   1 
ATOM 4875 C CA  . CYS B 2 100 ? 130.211 142.878 172.383 1.00 46.43  ? 100 CYS B CA  1 
ATOM 4876 C C   . CYS B 2 100 ? 129.407 142.007 171.432 1.00 46.43  ? 100 CYS B C   1 
ATOM 4877 O O   . CYS B 2 100 ? 128.349 141.495 171.809 1.00 46.43  ? 100 CYS B O   1 
ATOM 4878 C CB  . CYS B 2 100 ? 131.052 142.031 173.331 1.00 46.43  ? 100 CYS B CB  1 
ATOM 4879 S SG  . CYS B 2 100 ? 132.112 140.804 172.597 1.00 46.43  ? 100 CYS B SG  1 
ATOM 4880 N N   . HIS B 2 101 ? 129.884 141.861 170.201 1.00 39.31  ? 101 HIS B N   1 
ATOM 4881 C CA  . HIS B 2 101 ? 129.124 141.184 169.162 1.00 39.31  ? 101 HIS B CA  1 
ATOM 4882 C C   . HIS B 2 101 ? 130.012 140.216 168.397 1.00 39.31  ? 101 HIS B C   1 
ATOM 4883 O O   . HIS B 2 101 ? 131.136 140.552 168.032 1.00 39.31  ? 101 HIS B O   1 
ATOM 4884 C CB  . HIS B 2 101 ? 128.506 142.207 168.210 1.00 39.31  ? 101 HIS B CB  1 
ATOM 4885 C CG  . HIS B 2 101 ? 127.945 141.619 166.953 1.00 39.31  ? 101 HIS B CG  1 
ATOM 4886 N ND1 . HIS B 2 101 ? 128.266 142.099 165.703 1.00 39.31  ? 101 HIS B ND1 1 
ATOM 4887 C CD2 . HIS B 2 101 ? 127.079 140.599 166.753 1.00 39.31  ? 101 HIS B CD2 1 
ATOM 4888 C CE1 . HIS B 2 101 ? 127.621 141.400 164.786 1.00 39.31  ? 101 HIS B CE1 1 
ATOM 4889 N NE2 . HIS B 2 101 ? 126.896 140.482 165.397 1.00 39.31  ? 101 HIS B NE2 1 
ATOM 4890 N N   . VAL B 2 102 ? 129.509 139.007 168.168 1.00 39.51  ? 102 VAL B N   1 
ATOM 4891 C CA  . VAL B 2 102 ? 130.176 138.031 167.321 1.00 39.51  ? 102 VAL B CA  1 
ATOM 4892 C C   . VAL B 2 102 ? 129.088 137.434 166.436 1.00 39.51  ? 102 VAL B C   1 
ATOM 4893 O O   . VAL B 2 102 ? 127.900 137.495 166.756 1.00 39.51  ? 102 VAL B O   1 
ATOM 4894 C CB  . VAL B 2 102 ? 130.910 136.950 168.159 1.00 39.51  ? 102 VAL B CB  1 
ATOM 4895 C CG1 . VAL B 2 102 ? 129.926 136.115 168.938 1.00 39.51  ? 102 VAL B CG1 1 
ATOM 4896 C CG2 . VAL B 2 102 ? 131.872 136.092 167.331 1.00 39.51  ? 102 VAL B CG2 1 
ATOM 4897 N N   . ARG B 2 103 ? 129.492 136.880 165.296 1.00 37.37  ? 103 ARG B N   1 
ATOM 4898 C CA  . ARG B 2 103 ? 128.565 136.252 164.367 1.00 37.37  ? 103 ARG B CA  1 
ATOM 4899 C C   . ARG B 2 103 ? 129.091 134.874 163.959 1.00 37.37  ? 103 ARG B C   1 
ATOM 4900 O O   . ARG B 2 103 ? 129.263 134.589 162.783 1.00 37.37  ? 103 ARG B O   1 
ATOM 4901 C CB  . ARG B 2 103 ? 128.303 137.118 163.133 1.00 37.37  ? 103 ARG B CB  1 
ATOM 4902 C CG  . ARG B 2 103 ? 126.965 136.797 162.467 1.00 37.37  ? 103 ARG B CG  1 
ATOM 4903 C CD  . ARG B 2 103 ? 126.884 137.221 161.020 1.00 37.37  ? 103 ARG B CD  1 
ATOM 4904 N NE  . ARG B 2 103 ? 126.187 138.484 160.831 1.00 37.37  ? 103 ARG B NE  1 
ATOM 4905 C CZ  . ARG B 2 103 ? 125.836 138.957 159.645 1.00 37.37  ? 103 ARG B CZ  1 
ATOM 4906 N NH1 . ARG B 2 103 ? 126.121 138.306 158.532 1.00 37.37  ? 103 ARG B NH1 1 
ATOM 4907 N NH2 . ARG B 2 103 ? 125.177 140.108 159.575 1.00 37.37  ? 103 ARG B NH2 1 
ATOM 4908 N N   . VAL B 2 104 ? 129.407 134.013 164.920 1.00 38.79  ? 104 VAL B N   1 
ATOM 4909 C CA  . VAL B 2 104 ? 129.735 132.650 164.514 1.00 38.79  ? 104 VAL B CA  1 
ATOM 4910 C C   . VAL B 2 104 ? 128.438 131.963 164.120 1.00 38.79  ? 104 VAL B C   1 
ATOM 4911 O O   . VAL B 2 104 ? 127.703 131.453 164.972 1.00 38.79  ? 104 VAL B O   1 
ATOM 4912 C CB  . VAL B 2 104 ? 130.463 131.864 165.613 1.00 38.79  ? 104 VAL B CB  1 
ATOM 4913 C CG1 . VAL B 2 104 ? 130.854 130.494 165.091 1.00 38.79  ? 104 VAL B CG1 1 
ATOM 4914 C CG2 . VAL B 2 104 ? 131.687 132.605 166.039 1.00 38.79  ? 104 VAL B CG2 1 
ATOM 4915 N N   . GLY B 2 105 ? 128.140 131.967 162.823 1.00 37.30  ? 105 GLY B N   1 
ATOM 4916 C CA  . GLY B 2 105 ? 126.896 131.415 162.327 1.00 37.30  ? 105 GLY B CA  1 
ATOM 4917 C C   . GLY B 2 105 ? 125.722 132.345 162.533 1.00 37.30  ? 105 GLY B C   1 
ATOM 4918 O O   . GLY B 2 105 ? 125.166 132.880 161.571 1.00 37.30  ? 105 GLY B O   1 
ATOM 4919 N N   . ARG B 2 106 ? 125.343 132.548 163.790 1.00 41.17  ? 106 ARG B N   1 
ATOM 4920 C CA  . ARG B 2 106 ? 124.224 133.398 164.165 1.00 41.17  ? 106 ARG B CA  1 
ATOM 4921 C C   . ARG B 2 106 ? 124.748 134.647 164.860 1.00 41.17  ? 106 ARG B C   1 
ATOM 4922 O O   . ARG B 2 106 ? 125.768 134.597 165.552 1.00 41.17  ? 106 ARG B O   1 
ATOM 4923 C CB  . ARG B 2 106 ? 123.260 132.640 165.081 1.00 41.17  ? 106 ARG B CB  1 
ATOM 4924 C CG  . ARG B 2 106 ? 121.841 133.168 165.079 1.00 41.17  ? 106 ARG B CG  1 
ATOM 4925 C CD  . ARG B 2 106 ? 121.099 132.745 166.338 1.00 41.17  ? 106 ARG B CD  1 
ATOM 4926 N NE  . ARG B 2 106 ? 120.236 131.591 166.110 1.00 41.17  ? 106 ARG B NE  1 
ATOM 4927 C CZ  . ARG B 2 106 ? 119.032 131.645 165.556 1.00 41.17  ? 106 ARG B CZ  1 
ATOM 4928 N NH1 . ARG B 2 106 ? 118.495 132.793 165.173 1.00 41.17  ? 106 ARG B NH1 1 
ATOM 4929 N NH2 . ARG B 2 106 ? 118.346 130.519 165.384 1.00 41.17  ? 106 ARG B NH2 1 
ATOM 4930 N N   . SER B 2 107 ? 124.059 135.767 164.660 1.00 41.95  ? 107 SER B N   1 
ATOM 4931 C CA  . SER B 2 107 ? 124.473 137.018 165.281 1.00 41.95  ? 107 SER B CA  1 
ATOM 4932 C C   . SER B 2 107 ? 124.231 136.970 166.783 1.00 41.95  ? 107 SER B C   1 
ATOM 4933 O O   . SER B 2 107 ? 123.115 136.708 167.238 1.00 41.95  ? 107 SER B O   1 
ATOM 4934 C CB  . SER B 2 107 ? 123.722 138.192 164.659 1.00 41.95  ? 107 SER B CB  1 
ATOM 4935 O OG  . SER B 2 107 ? 124.158 138.432 163.334 1.00 41.95  ? 107 SER B OG  1 
ATOM 4936 N N   . TYR B 2 108 ? 125.287 137.231 167.551 1.00 44.16  ? 108 TYR B N   1 
ATOM 4937 C CA  . TYR B 2 108 ? 125.286 137.011 168.992 1.00 44.16  ? 108 TYR B CA  1 
ATOM 4938 C C   . TYR B 2 108 ? 125.738 138.288 169.674 1.00 44.16  ? 108 TYR B C   1 
ATOM 4939 O O   . TYR B 2 108 ? 126.783 138.837 169.322 1.00 44.16  ? 108 TYR B O   1 
ATOM 4940 C CB  . TYR B 2 108 ? 126.213 135.848 169.342 1.00 44.16  ? 108 TYR B CB  1 
ATOM 4941 C CG  . TYR B 2 108 ? 125.575 134.503 169.128 1.00 44.16  ? 108 TYR B CG  1 
ATOM 4942 C CD1 . TYR B 2 108 ? 124.204 134.336 169.245 1.00 44.16  ? 108 TYR B CD1 1 
ATOM 4943 C CD2 . TYR B 2 108 ? 126.334 133.422 168.714 1.00 44.16  ? 108 TYR B CD2 1 
ATOM 4944 C CE1 . TYR B 2 108 ? 123.619 133.110 169.024 1.00 44.16  ? 108 TYR B CE1 1 
ATOM 4945 C CE2 . TYR B 2 108 ? 125.762 132.195 168.487 1.00 44.16  ? 108 TYR B CE2 1 
ATOM 4946 C CZ  . TYR B 2 108 ? 124.404 132.043 168.642 1.00 44.16  ? 108 TYR B CZ  1 
ATOM 4947 O OH  . TYR B 2 108 ? 123.823 130.818 168.410 1.00 44.16  ? 108 TYR B OH  1 
ATOM 4948 N N   . PHE B 2 109 ? 124.970 138.753 170.650 1.00 45.83  ? 109 PHE B N   1 
ATOM 4949 C CA  . PHE B 2 109 ? 125.243 140.012 171.322 1.00 45.83  ? 109 PHE B CA  1 
ATOM 4950 C C   . PHE B 2 109 ? 125.473 139.786 172.808 1.00 45.83  ? 109 PHE B C   1 
ATOM 4951 O O   . PHE B 2 109 ? 125.004 138.803 173.387 1.00 45.83  ? 109 PHE B O   1 
ATOM 4952 C CB  . PHE B 2 109 ? 124.092 141.002 171.131 1.00 45.83  ? 109 PHE B CB  1 
ATOM 4953 C CG  . PHE B 2 109 ? 124.153 141.764 169.842 1.00 45.83  ? 109 PHE B CG  1 
ATOM 4954 C CD1 . PHE B 2 109 ? 123.914 141.132 168.635 1.00 45.83  ? 109 PHE B CD1 1 
ATOM 4955 C CD2 . PHE B 2 109 ? 124.447 143.115 169.840 1.00 45.83  ? 109 PHE B CD2 1 
ATOM 4956 C CE1 . PHE B 2 109 ? 123.966 141.834 167.450 1.00 45.83  ? 109 PHE B CE1 1 
ATOM 4957 C CE2 . PHE B 2 109 ? 124.501 143.821 168.657 1.00 45.83  ? 109 PHE B CE2 1 
ATOM 4958 C CZ  . PHE B 2 109 ? 124.260 143.179 167.461 1.00 45.83  ? 109 PHE B CZ  1 
ATOM 4959 N N   . GLY B 2 110 ? 126.208 140.712 173.422 1.00 49.18  ? 110 GLY B N   1 
ATOM 4960 C CA  . GLY B 2 110 ? 126.460 140.662 174.844 1.00 49.18  ? 110 GLY B CA  1 
ATOM 4961 C C   . GLY B 2 110 ? 125.358 141.324 175.650 1.00 49.18  ? 110 GLY B C   1 
ATOM 4962 O O   . GLY B 2 110 ? 124.381 141.850 175.120 1.00 49.18  ? 110 GLY B O   1 
ATOM 4963 N N   . GLN B 2 111 ? 125.532 141.287 176.971 1.00 52.79  ? 111 GLN B N   1 
ATOM 4964 C CA  . GLN B 2 111 ? 124.562 141.911 177.862 1.00 52.79  ? 111 GLN B CA  1 
ATOM 4965 C C   . GLN B 2 111 ? 124.811 143.408 177.998 1.00 52.79  ? 111 GLN B C   1 
ATOM 4966 O O   . GLN B 2 111 ? 123.861 144.188 178.122 1.00 52.79  ? 111 GLN B O   1 
ATOM 4967 C CB  . GLN B 2 111 ? 124.600 141.231 179.229 1.00 52.79  ? 111 GLN B CB  1 
ATOM 4968 C CG  . GLN B 2 111 ? 124.357 139.728 179.183 1.00 52.79  ? 111 GLN B CG  1 
ATOM 4969 C CD  . GLN B 2 111 ? 122.887 139.350 179.285 1.00 52.79  ? 111 GLN B CD  1 
ATOM 4970 O OE1 . GLN B 2 111 ? 122.031 139.927 178.615 1.00 52.79  ? 111 GLN B OE1 1 
ATOM 4971 N NE2 . GLN B 2 111 ? 122.591 138.369 180.130 1.00 52.79  ? 111 GLN B NE2 1 
ATOM 4972 N N   . GLY B 2 112 ? 126.066 143.824 177.980 1.00 51.70  ? 112 GLY B N   1 
ATOM 4973 C CA  . GLY B 2 112 ? 126.373 145.244 178.048 1.00 51.70  ? 112 GLY B CA  1 
ATOM 4974 C C   . GLY B 2 112 ? 126.575 145.730 179.468 1.00 51.70  ? 112 GLY B C   1 
ATOM 4975 O O   . GLY B 2 112 ? 125.814 145.419 180.383 1.00 51.70  ? 112 GLY B O   1 
ATOM 4976 N N   . THR B 2 113 ? 127.627 146.524 179.650 1.00 51.65  ? 113 THR B N   1 
ATOM 4977 C CA  . THR B 2 113 ? 127.984 147.062 180.954 1.00 51.65  ? 113 THR B CA  1 
ATOM 4978 C C   . THR B 2 113 ? 128.004 148.580 180.885 1.00 51.65  ? 113 THR B C   1 
ATOM 4979 O O   . THR B 2 113 ? 128.407 149.154 179.872 1.00 51.65  ? 113 THR B O   1 
ATOM 4980 C CB  . THR B 2 113 ? 129.349 146.546 181.427 1.00 51.65  ? 113 THR B CB  1 
ATOM 4981 O OG1 . THR B 2 113 ? 130.363 146.957 180.504 1.00 51.65  ? 113 THR B OG1 1 
ATOM 4982 C CG2 . THR B 2 113 ? 129.347 145.035 181.547 1.00 51.65  ? 113 THR B CG2 1 
ATOM 4983 N N   . GLN B 2 114 ? 127.559 149.223 181.964 1.00 56.03  ? 114 GLN B N   1 
ATOM 4984 C CA  . GLN B 2 114 ? 127.481 150.678 181.999 1.00 56.03  ? 114 GLN B CA  1 
ATOM 4985 C C   . GLN B 2 114 ? 128.872 151.293 182.082 1.00 56.03  ? 114 GLN B C   1 
ATOM 4986 O O   . GLN B 2 114 ? 129.661 150.966 182.972 1.00 56.03  ? 114 GLN B O   1 
ATOM 4987 C CB  . GLN B 2 114 ? 126.639 151.137 183.184 1.00 56.03  ? 114 GLN B CB  1 
ATOM 4988 C CG  . GLN B 2 114 ? 126.236 152.595 183.113 1.00 56.03  ? 114 GLN B CG  1 
ATOM 4989 C CD  . GLN B 2 114 ? 125.196 152.851 182.054 1.00 56.03  ? 114 GLN B CD  1 
ATOM 4990 O OE1 . GLN B 2 114 ? 124.315 152.026 181.827 1.00 56.03  ? 114 GLN B OE1 1 
ATOM 4991 N NE2 . GLN B 2 114 ? 125.292 153.997 181.396 1.00 56.03  ? 114 GLN B NE2 1 
ATOM 4992 N N   . VAL B 2 115 ? 129.163 152.195 181.149 1.00 57.70  ? 115 VAL B N   1 
ATOM 4993 C CA  . VAL B 2 115 ? 130.482 152.798 181.004 1.00 57.70  ? 115 VAL B CA  1 
ATOM 4994 C C   . VAL B 2 115 ? 130.204 154.291 181.210 1.00 57.70  ? 115 VAL B C   1 
ATOM 4995 O O   . VAL B 2 115 ? 130.589 155.150 180.406 1.00 57.70  ? 115 VAL B O   1 
ATOM 4996 C CB  . VAL B 2 115 ? 131.133 152.402 179.653 1.00 57.70  ? 115 VAL B CB  1 
ATOM 4997 C CG1 . VAL B 2 115 ? 132.549 152.970 179.444 1.00 57.70  ? 115 VAL B CG1 1 
ATOM 4998 C CG2 . VAL B 2 115 ? 131.196 150.896 179.521 1.00 57.70  ? 115 VAL B CG2 1 
ATOM 4999 N N   . SER B 2 116 ? 129.366 154.582 182.207 1.00 63.05  ? 116 SER B N   1 
ATOM 5000 C CA  . SER B 2 116 ? 128.986 155.956 182.524 1.00 63.05  ? 116 SER B CA  1 
ATOM 5001 C C   . SER B 2 116 ? 130.206 156.811 182.852 1.00 63.05  ? 116 SER B C   1 
ATOM 5002 O O   . SER B 2 116 ? 131.072 156.414 183.636 1.00 63.05  ? 116 SER B O   1 
ATOM 5003 C CB  . SER B 2 116 ? 128.006 155.967 183.697 1.00 63.05  ? 116 SER B CB  1 
ATOM 5004 O OG  . SER B 2 116 ? 127.397 157.236 183.838 1.00 63.05  ? 116 SER B OG  1 
ATOM 5005 N N   . VAL B 2 117 ? 130.274 157.983 182.228 1.00 65.37  ? 117 VAL B N   1 
ATOM 5006 C CA  . VAL B 2 117 ? 131.439 158.855 182.286 1.00 65.37  ? 117 VAL B CA  1 
ATOM 5007 C C   . VAL B 2 117 ? 130.988 160.189 182.862 1.00 65.37  ? 117 VAL B C   1 
ATOM 5008 O O   . VAL B 2 117 ? 130.038 160.801 182.360 1.00 65.37  ? 117 VAL B O   1 
ATOM 5009 C CB  . VAL B 2 117 ? 132.077 159.024 180.898 1.00 65.37  ? 117 VAL B CB  1 
ATOM 5010 C CG1 . VAL B 2 117 ? 132.930 160.286 180.822 1.00 65.37  ? 117 VAL B CG1 1 
ATOM 5011 C CG2 . VAL B 2 117 ? 132.890 157.790 180.534 1.00 65.37  ? 117 VAL B CG2 1 
ATOM 5012 N N   . SER B 2 118 ? 131.652 160.627 183.928 1.00 71.45  ? 118 SER B N   1 
ATOM 5013 C CA  . SER B 2 118 ? 131.316 161.898 184.548 1.00 71.45  ? 118 SER B CA  1 
ATOM 5014 C C   . SER B 2 118 ? 131.833 163.060 183.709 1.00 71.45  ? 118 SER B C   1 
ATOM 5015 O O   . SER B 2 118 ? 132.780 162.924 182.930 1.00 71.45  ? 118 SER B O   1 
ATOM 5016 C CB  . SER B 2 118 ? 131.893 161.975 185.960 1.00 71.45  ? 118 SER B CB  1 
ATOM 5017 O OG  . SER B 2 118 ? 131.278 161.026 186.814 1.00 71.45  ? 118 SER B OG  1 
ATOM 5018 N N   . ALA B 2 119 ? 131.193 164.213 183.875 1.00 77.63  ? 119 ALA B N   1 
ATOM 5019 C CA  . ALA B 2 119 ? 131.558 165.430 183.163 1.00 77.63  ? 119 ALA B CA  1 
ATOM 5020 C C   . ALA B 2 119 ? 132.258 166.390 184.115 1.00 77.63  ? 119 ALA B C   1 
ATOM 5021 O O   . ALA B 2 119 ? 131.768 166.644 185.220 1.00 77.63  ? 119 ALA B O   1 
ATOM 5022 C CB  . ALA B 2 119 ? 130.323 166.095 182.555 1.00 77.63  ? 119 ALA B CB  1 
ATOM 5023 N N   . GLY B 2 120 ? 133.400 166.917 183.685 1.00 82.04  ? 120 GLY B N   1 
ATOM 5024 C CA  . GLY B 2 120 ? 134.159 167.850 184.497 1.00 82.04  ? 120 GLY B CA  1 
ATOM 5025 C C   . GLY B 2 120 ? 135.209 168.611 183.712 1.00 82.04  ? 120 GLY B C   1 
ATOM 5026 O O   . GLY B 2 120 ? 136.115 169.211 184.290 1.00 82.04  ? 120 GLY B O   1 
# 
