data_9CPQ
# 
_entry.id   9CPQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.404 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9CPQ         pdb_00009cpq 10.2210/pdb9cpq/pdb 
WWPDB D_1000286039 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-06-25 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9CPQ 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-18 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              wilson@scripps.edu 
_pdbx_contact_author.name_first         Ian 
_pdbx_contact_author.name_last          Wilson 
_pdbx_contact_author.name_mi            A. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-6469-2419 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Feng, Z.'     1 ? 
'Wilson, I.A.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structures of CR3022-like antibodies' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Feng, Z.'     1 ? 
primary 'Wilson, I.A.' 2 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Spike protein S1' 23104.867 1 ? ? ? ? 
2 polymer     man 'CC12.3 Fab heavy chain' 23377.150 1 ? ? ? ? 
3 polymer     man 'CC12.3 Fab light chain' 23344.883 1 ? ? ? ? 
4 polymer     man 'M22-44 Fab heavy chain' 23485.490 1 ? ? ? ? 
5 polymer     man 'M22-44 Fab light chain' 24289.885 1 ? ? ? ? 
6 branched    man 
'beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose' 586.542   1 ? 
? ? ? 
7 non-polymer syn 'CITRIC ACID' 192.124   3 ? ? ? ? 
8 water       nat water 18.015    7 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSGHHHHHH
;
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKSGHHHHHH
;
A ? 
2 'polypeptide(L)' no no 
;QVQLVESGGGLIQPGGSLRLSCAASGFTVSSNYMSWVRQAPGKGLEWVSVIYSGGSTFYADSVKGRFTISRDNSKSTLYL
QMNSLRVEDTAVYYCARDFGDFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNS
GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
;
;QVQLVESGGGLIQPGGSLRLSCAASGFTVSSNYMSWVRQAPGKGLEWVSVIYSGGSTFYADSVKGRFTISRDNSKSTLYL
QMNSLRVEDTAVYYCARDFGDFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNS
GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
;
F ? 
3 'polypeptide(L)' no no 
;EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEP
EDFAVYYCQQYGSSPRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
;EIVLTQSPGTLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEP
EDFAVYYCQQYGSSPRTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
G ? 
4 'polypeptide(L)' no no 
;QMQLVQSGTEVKKPGESLKISCKGSGYGLITYWIGWVRQMSGKGLEWMGIIYPADSETRYSPSFQGQVTISADKSINTAY
LQWSSLKASDTAIYYCAGGSGIFTPMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
;
;QMQLVQSGTEVKKPGESLKISCKGSGYGLITYWIGWVRQMSGKGLEWMGIIYPADSETRYSPSFQGQVTISADKSINTAY
LQWSSLKASDTAIYYCAGGSGIFTPMDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
;
H ? 
5 'polypeptide(L)' no no 
;DIQLTQSPDSLAVSLGERATINCKSSQSVLYSSINKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLT
ISSLQAEDVAVYYCQQYYSTPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNAL
QSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
;DIQLTQSPDSLAVSLGERATINCKSSQSVLYSSINKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLT
ISSLQAEDVAVYYCQQYYSTPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNAL
QSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
L ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
7 'CITRIC ACID' CIT 
8 water         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   THR n 
1 2   ASN n 
1 3   LEU n 
1 4   CYS n 
1 5   PRO n 
1 6   PHE n 
1 7   GLY n 
1 8   GLU n 
1 9   VAL n 
1 10  PHE n 
1 11  ASN n 
1 12  ALA n 
1 13  THR n 
1 14  ARG n 
1 15  PHE n 
1 16  ALA n 
1 17  SER n 
1 18  VAL n 
1 19  TYR n 
1 20  ALA n 
1 21  TRP n 
1 22  ASN n 
1 23  ARG n 
1 24  LYS n 
1 25  ARG n 
1 26  ILE n 
1 27  SER n 
1 28  ASN n 
1 29  CYS n 
1 30  VAL n 
1 31  ALA n 
1 32  ASP n 
1 33  TYR n 
1 34  SER n 
1 35  VAL n 
1 36  LEU n 
1 37  TYR n 
1 38  ASN n 
1 39  SER n 
1 40  ALA n 
1 41  SER n 
1 42  PHE n 
1 43  SER n 
1 44  THR n 
1 45  PHE n 
1 46  LYS n 
1 47  CYS n 
1 48  TYR n 
1 49  GLY n 
1 50  VAL n 
1 51  SER n 
1 52  PRO n 
1 53  THR n 
1 54  LYS n 
1 55  LEU n 
1 56  ASN n 
1 57  ASP n 
1 58  LEU n 
1 59  CYS n 
1 60  PHE n 
1 61  THR n 
1 62  ASN n 
1 63  VAL n 
1 64  TYR n 
1 65  ALA n 
1 66  ASP n 
1 67  SER n 
1 68  PHE n 
1 69  VAL n 
1 70  ILE n 
1 71  ARG n 
1 72  GLY n 
1 73  ASP n 
1 74  GLU n 
1 75  VAL n 
1 76  ARG n 
1 77  GLN n 
1 78  ILE n 
1 79  ALA n 
1 80  PRO n 
1 81  GLY n 
1 82  GLN n 
1 83  THR n 
1 84  GLY n 
1 85  LYS n 
1 86  ILE n 
1 87  ALA n 
1 88  ASP n 
1 89  TYR n 
1 90  ASN n 
1 91  TYR n 
1 92  LYS n 
1 93  LEU n 
1 94  PRO n 
1 95  ASP n 
1 96  ASP n 
1 97  PHE n 
1 98  THR n 
1 99  GLY n 
1 100 CYS n 
1 101 VAL n 
1 102 ILE n 
1 103 ALA n 
1 104 TRP n 
1 105 ASN n 
1 106 SER n 
1 107 ASN n 
1 108 ASN n 
1 109 LEU n 
1 110 ASP n 
1 111 SER n 
1 112 LYS n 
1 113 VAL n 
1 114 GLY n 
1 115 GLY n 
1 116 ASN n 
1 117 TYR n 
1 118 ASN n 
1 119 TYR n 
1 120 LEU n 
1 121 TYR n 
1 122 ARG n 
1 123 LEU n 
1 124 PHE n 
1 125 ARG n 
1 126 LYS n 
1 127 SER n 
1 128 ASN n 
1 129 LEU n 
1 130 LYS n 
1 131 PRO n 
1 132 PHE n 
1 133 GLU n 
1 134 ARG n 
1 135 ASP n 
1 136 ILE n 
1 137 SER n 
1 138 THR n 
1 139 GLU n 
1 140 ILE n 
1 141 TYR n 
1 142 GLN n 
1 143 ALA n 
1 144 GLY n 
1 145 SER n 
1 146 THR n 
1 147 PRO n 
1 148 CYS n 
1 149 ASN n 
1 150 GLY n 
1 151 VAL n 
1 152 GLU n 
1 153 GLY n 
1 154 PHE n 
1 155 ASN n 
1 156 CYS n 
1 157 TYR n 
1 158 PHE n 
1 159 PRO n 
1 160 LEU n 
1 161 GLN n 
1 162 SER n 
1 163 TYR n 
1 164 GLY n 
1 165 PHE n 
1 166 GLN n 
1 167 PRO n 
1 168 THR n 
1 169 ASN n 
1 170 GLY n 
1 171 VAL n 
1 172 GLY n 
1 173 TYR n 
1 174 GLN n 
1 175 PRO n 
1 176 TYR n 
1 177 ARG n 
1 178 VAL n 
1 179 VAL n 
1 180 VAL n 
1 181 LEU n 
1 182 SER n 
1 183 PHE n 
1 184 GLU n 
1 185 LEU n 
1 186 LEU n 
1 187 HIS n 
1 188 ALA n 
1 189 PRO n 
1 190 ALA n 
1 191 THR n 
1 192 VAL n 
1 193 CYS n 
1 194 GLY n 
1 195 PRO n 
1 196 LYS n 
1 197 LYS n 
1 198 SER n 
1 199 GLY n 
1 200 HIS n 
1 201 HIS n 
1 202 HIS n 
1 203 HIS n 
1 204 HIS n 
1 205 HIS n 
2 1   GLN n 
2 2   VAL n 
2 3   GLN n 
2 4   LEU n 
2 5   VAL n 
2 6   GLU n 
2 7   SER n 
2 8   GLY n 
2 9   GLY n 
2 10  GLY n 
2 11  LEU n 
2 12  ILE n 
2 13  GLN n 
2 14  PRO n 
2 15  GLY n 
2 16  GLY n 
2 17  SER n 
2 18  LEU n 
2 19  ARG n 
2 20  LEU n 
2 21  SER n 
2 22  CYS n 
2 23  ALA n 
2 24  ALA n 
2 25  SER n 
2 26  GLY n 
2 27  PHE n 
2 28  THR n 
2 29  VAL n 
2 30  SER n 
2 31  SER n 
2 32  ASN n 
2 33  TYR n 
2 34  MET n 
2 35  SER n 
2 36  TRP n 
2 37  VAL n 
2 38  ARG n 
2 39  GLN n 
2 40  ALA n 
2 41  PRO n 
2 42  GLY n 
2 43  LYS n 
2 44  GLY n 
2 45  LEU n 
2 46  GLU n 
2 47  TRP n 
2 48  VAL n 
2 49  SER n 
2 50  VAL n 
2 51  ILE n 
2 52  TYR n 
2 53  SER n 
2 54  GLY n 
2 55  GLY n 
2 56  SER n 
2 57  THR n 
2 58  PHE n 
2 59  TYR n 
2 60  ALA n 
2 61  ASP n 
2 62  SER n 
2 63  VAL n 
2 64  LYS n 
2 65  GLY n 
2 66  ARG n 
2 67  PHE n 
2 68  THR n 
2 69  ILE n 
2 70  SER n 
2 71  ARG n 
2 72  ASP n 
2 73  ASN n 
2 74  SER n 
2 75  LYS n 
2 76  SER n 
2 77  THR n 
2 78  LEU n 
2 79  TYR n 
2 80  LEU n 
2 81  GLN n 
2 82  MET n 
2 83  ASN n 
2 84  SER n 
2 85  LEU n 
2 86  ARG n 
2 87  VAL n 
2 88  GLU n 
2 89  ASP n 
2 90  THR n 
2 91  ALA n 
2 92  VAL n 
2 93  TYR n 
2 94  TYR n 
2 95  CYS n 
2 96  ALA n 
2 97  ARG n 
2 98  ASP n 
2 99  PHE n 
2 100 GLY n 
2 101 ASP n 
2 102 PHE n 
2 103 TYR n 
2 104 PHE n 
2 105 ASP n 
2 106 TYR n 
2 107 TRP n 
2 108 GLY n 
2 109 GLN n 
2 110 GLY n 
2 111 THR n 
2 112 LEU n 
2 113 VAL n 
2 114 THR n 
2 115 VAL n 
2 116 SER n 
2 117 SER n 
2 118 ALA n 
2 119 SER n 
2 120 THR n 
2 121 LYS n 
2 122 GLY n 
2 123 PRO n 
2 124 SER n 
2 125 VAL n 
2 126 PHE n 
2 127 PRO n 
2 128 LEU n 
2 129 ALA n 
2 130 PRO n 
2 131 SER n 
2 132 SER n 
2 133 LYS n 
2 134 SER n 
2 135 THR n 
2 136 SER n 
2 137 GLY n 
2 138 GLY n 
2 139 THR n 
2 140 ALA n 
2 141 ALA n 
2 142 LEU n 
2 143 GLY n 
2 144 CYS n 
2 145 LEU n 
2 146 VAL n 
2 147 LYS n 
2 148 ASP n 
2 149 TYR n 
2 150 PHE n 
2 151 PRO n 
2 152 GLU n 
2 153 PRO n 
2 154 VAL n 
2 155 THR n 
2 156 VAL n 
2 157 SER n 
2 158 TRP n 
2 159 ASN n 
2 160 SER n 
2 161 GLY n 
2 162 ALA n 
2 163 LEU n 
2 164 THR n 
2 165 SER n 
2 166 GLY n 
2 167 VAL n 
2 168 HIS n 
2 169 THR n 
2 170 PHE n 
2 171 PRO n 
2 172 ALA n 
2 173 VAL n 
2 174 LEU n 
2 175 GLN n 
2 176 SER n 
2 177 SER n 
2 178 GLY n 
2 179 LEU n 
2 180 TYR n 
2 181 SER n 
2 182 LEU n 
2 183 SER n 
2 184 SER n 
2 185 VAL n 
2 186 VAL n 
2 187 THR n 
2 188 VAL n 
2 189 PRO n 
2 190 SER n 
2 191 SER n 
2 192 SER n 
2 193 LEU n 
2 194 GLY n 
2 195 THR n 
2 196 GLN n 
2 197 THR n 
2 198 TYR n 
2 199 ILE n 
2 200 CYS n 
2 201 ASN n 
2 202 VAL n 
2 203 ASN n 
2 204 HIS n 
2 205 LYS n 
2 206 PRO n 
2 207 SER n 
2 208 ASN n 
2 209 THR n 
2 210 LYS n 
2 211 VAL n 
2 212 ASP n 
2 213 LYS n 
2 214 LYS n 
2 215 VAL n 
2 216 GLU n 
2 217 PRO n 
2 218 LYS n 
2 219 SER n 
2 220 CYS n 
3 1   GLU n 
3 2   ILE n 
3 3   VAL n 
3 4   LEU n 
3 5   THR n 
3 6   GLN n 
3 7   SER n 
3 8   PRO n 
3 9   GLY n 
3 10  THR n 
3 11  LEU n 
3 12  SER n 
3 13  LEU n 
3 14  SER n 
3 15  PRO n 
3 16  GLY n 
3 17  GLU n 
3 18  ARG n 
3 19  ALA n 
3 20  THR n 
3 21  LEU n 
3 22  SER n 
3 23  CYS n 
3 24  ARG n 
3 25  ALA n 
3 26  SER n 
3 27  GLN n 
3 28  SER n 
3 29  VAL n 
3 30  SER n 
3 31  SER n 
3 32  TYR n 
3 33  LEU n 
3 34  ALA n 
3 35  TRP n 
3 36  TYR n 
3 37  GLN n 
3 38  GLN n 
3 39  LYS n 
3 40  PRO n 
3 41  GLY n 
3 42  GLN n 
3 43  ALA n 
3 44  PRO n 
3 45  ARG n 
3 46  LEU n 
3 47  LEU n 
3 48  ILE n 
3 49  TYR n 
3 50  GLY n 
3 51  ALA n 
3 52  SER n 
3 53  SER n 
3 54  ARG n 
3 55  ALA n 
3 56  THR n 
3 57  GLY n 
3 58  ILE n 
3 59  PRO n 
3 60  ASP n 
3 61  ARG n 
3 62  PHE n 
3 63  SER n 
3 64  GLY n 
3 65  SER n 
3 66  GLY n 
3 67  SER n 
3 68  GLY n 
3 69  THR n 
3 70  ASP n 
3 71  PHE n 
3 72  THR n 
3 73  LEU n 
3 74  THR n 
3 75  ILE n 
3 76  SER n 
3 77  ARG n 
3 78  LEU n 
3 79  GLU n 
3 80  PRO n 
3 81  GLU n 
3 82  ASP n 
3 83  PHE n 
3 84  ALA n 
3 85  VAL n 
3 86  TYR n 
3 87  TYR n 
3 88  CYS n 
3 89  GLN n 
3 90  GLN n 
3 91  TYR n 
3 92  GLY n 
3 93  SER n 
3 94  SER n 
3 95  PRO n 
3 96  ARG n 
3 97  THR n 
3 98  PHE n 
3 99  GLY n 
3 100 GLN n 
3 101 GLY n 
3 102 THR n 
3 103 LYS n 
3 104 LEU n 
3 105 GLU n 
3 106 ILE n 
3 107 LYS n 
3 108 ARG n 
3 109 THR n 
3 110 VAL n 
3 111 ALA n 
3 112 ALA n 
3 113 PRO n 
3 114 SER n 
3 115 VAL n 
3 116 PHE n 
3 117 ILE n 
3 118 PHE n 
3 119 PRO n 
3 120 PRO n 
3 121 SER n 
3 122 ASP n 
3 123 GLU n 
3 124 GLN n 
3 125 LEU n 
3 126 LYS n 
3 127 SER n 
3 128 GLY n 
3 129 THR n 
3 130 ALA n 
3 131 SER n 
3 132 VAL n 
3 133 VAL n 
3 134 CYS n 
3 135 LEU n 
3 136 LEU n 
3 137 ASN n 
3 138 ASN n 
3 139 PHE n 
3 140 TYR n 
3 141 PRO n 
3 142 ARG n 
3 143 GLU n 
3 144 ALA n 
3 145 LYS n 
3 146 VAL n 
3 147 GLN n 
3 148 TRP n 
3 149 LYS n 
3 150 VAL n 
3 151 ASP n 
3 152 ASN n 
3 153 ALA n 
3 154 LEU n 
3 155 GLN n 
3 156 SER n 
3 157 GLY n 
3 158 ASN n 
3 159 SER n 
3 160 GLN n 
3 161 GLU n 
3 162 SER n 
3 163 VAL n 
3 164 THR n 
3 165 GLU n 
3 166 GLN n 
3 167 ASP n 
3 168 SER n 
3 169 LYS n 
3 170 ASP n 
3 171 SER n 
3 172 THR n 
3 173 TYR n 
3 174 SER n 
3 175 LEU n 
3 176 SER n 
3 177 SER n 
3 178 THR n 
3 179 LEU n 
3 180 THR n 
3 181 LEU n 
3 182 SER n 
3 183 LYS n 
3 184 ALA n 
3 185 ASP n 
3 186 TYR n 
3 187 GLU n 
3 188 LYS n 
3 189 HIS n 
3 190 LYS n 
3 191 VAL n 
3 192 TYR n 
3 193 ALA n 
3 194 CYS n 
3 195 GLU n 
3 196 VAL n 
3 197 THR n 
3 198 HIS n 
3 199 GLN n 
3 200 GLY n 
3 201 LEU n 
3 202 SER n 
3 203 SER n 
3 204 PRO n 
3 205 VAL n 
3 206 THR n 
3 207 LYS n 
3 208 SER n 
3 209 PHE n 
3 210 ASN n 
3 211 ARG n 
3 212 GLY n 
3 213 GLU n 
3 214 CYS n 
4 1   GLN n 
4 2   MET n 
4 3   GLN n 
4 4   LEU n 
4 5   VAL n 
4 6   GLN n 
4 7   SER n 
4 8   GLY n 
4 9   THR n 
4 10  GLU n 
4 11  VAL n 
4 12  LYS n 
4 13  LYS n 
4 14  PRO n 
4 15  GLY n 
4 16  GLU n 
4 17  SER n 
4 18  LEU n 
4 19  LYS n 
4 20  ILE n 
4 21  SER n 
4 22  CYS n 
4 23  LYS n 
4 24  GLY n 
4 25  SER n 
4 26  GLY n 
4 27  TYR n 
4 28  GLY n 
4 29  LEU n 
4 30  ILE n 
4 31  THR n 
4 32  TYR n 
4 33  TRP n 
4 34  ILE n 
4 35  GLY n 
4 36  TRP n 
4 37  VAL n 
4 38  ARG n 
4 39  GLN n 
4 40  MET n 
4 41  SER n 
4 42  GLY n 
4 43  LYS n 
4 44  GLY n 
4 45  LEU n 
4 46  GLU n 
4 47  TRP n 
4 48  MET n 
4 49  GLY n 
4 50  ILE n 
4 51  ILE n 
4 52  TYR n 
4 53  PRO n 
4 54  ALA n 
4 55  ASP n 
4 56  SER n 
4 57  GLU n 
4 58  THR n 
4 59  ARG n 
4 60  TYR n 
4 61  SER n 
4 62  PRO n 
4 63  SER n 
4 64  PHE n 
4 65  GLN n 
4 66  GLY n 
4 67  GLN n 
4 68  VAL n 
4 69  THR n 
4 70  ILE n 
4 71  SER n 
4 72  ALA n 
4 73  ASP n 
4 74  LYS n 
4 75  SER n 
4 76  ILE n 
4 77  ASN n 
4 78  THR n 
4 79  ALA n 
4 80  TYR n 
4 81  LEU n 
4 82  GLN n 
4 83  TRP n 
4 84  SER n 
4 85  SER n 
4 86  LEU n 
4 87  LYS n 
4 88  ALA n 
4 89  SER n 
4 90  ASP n 
4 91  THR n 
4 92  ALA n 
4 93  ILE n 
4 94  TYR n 
4 95  TYR n 
4 96  CYS n 
4 97  ALA n 
4 98  GLY n 
4 99  GLY n 
4 100 SER n 
4 101 GLY n 
4 102 ILE n 
4 103 PHE n 
4 104 THR n 
4 105 PRO n 
4 106 MET n 
4 107 ASP n 
4 108 VAL n 
4 109 TRP n 
4 110 GLY n 
4 111 GLN n 
4 112 GLY n 
4 113 THR n 
4 114 THR n 
4 115 VAL n 
4 116 THR n 
4 117 VAL n 
4 118 SER n 
4 119 SER n 
4 120 ALA n 
4 121 SER n 
4 122 THR n 
4 123 LYS n 
4 124 GLY n 
4 125 PRO n 
4 126 SER n 
4 127 VAL n 
4 128 PHE n 
4 129 PRO n 
4 130 LEU n 
4 131 ALA n 
4 132 PRO n 
4 133 SER n 
4 134 SER n 
4 135 LYS n 
4 136 SER n 
4 137 THR n 
4 138 SER n 
4 139 GLY n 
4 140 GLY n 
4 141 THR n 
4 142 ALA n 
4 143 ALA n 
4 144 LEU n 
4 145 GLY n 
4 146 CYS n 
4 147 LEU n 
4 148 VAL n 
4 149 LYS n 
4 150 ASP n 
4 151 TYR n 
4 152 PHE n 
4 153 PRO n 
4 154 GLU n 
4 155 PRO n 
4 156 VAL n 
4 157 THR n 
4 158 VAL n 
4 159 SER n 
4 160 TRP n 
4 161 ASN n 
4 162 SER n 
4 163 GLY n 
4 164 ALA n 
4 165 LEU n 
4 166 THR n 
4 167 SER n 
4 168 GLY n 
4 169 VAL n 
4 170 HIS n 
4 171 THR n 
4 172 PHE n 
4 173 PRO n 
4 174 ALA n 
4 175 VAL n 
4 176 LEU n 
4 177 GLN n 
4 178 SER n 
4 179 SER n 
4 180 GLY n 
4 181 LEU n 
4 182 TYR n 
4 183 SER n 
4 184 LEU n 
4 185 SER n 
4 186 SER n 
4 187 VAL n 
4 188 VAL n 
4 189 THR n 
4 190 VAL n 
4 191 PRO n 
4 192 SER n 
4 193 SER n 
4 194 SER n 
4 195 LEU n 
4 196 GLY n 
4 197 THR n 
4 198 GLN n 
4 199 THR n 
4 200 TYR n 
4 201 ILE n 
4 202 CYS n 
4 203 ASN n 
4 204 VAL n 
4 205 ASN n 
4 206 HIS n 
4 207 LYS n 
4 208 PRO n 
4 209 SER n 
4 210 ASN n 
4 211 THR n 
4 212 LYS n 
4 213 VAL n 
4 214 ASP n 
4 215 LYS n 
4 216 LYS n 
4 217 VAL n 
4 218 GLU n 
4 219 PRO n 
4 220 LYS n 
4 221 SER n 
4 222 CYS n 
5 1   ASP n 
5 2   ILE n 
5 3   GLN n 
5 4   LEU n 
5 5   THR n 
5 6   GLN n 
5 7   SER n 
5 8   PRO n 
5 9   ASP n 
5 10  SER n 
5 11  LEU n 
5 12  ALA n 
5 13  VAL n 
5 14  SER n 
5 15  LEU n 
5 16  GLY n 
5 17  GLU n 
5 18  ARG n 
5 19  ALA n 
5 20  THR n 
5 21  ILE n 
5 22  ASN n 
5 23  CYS n 
5 24  LYS n 
5 25  SER n 
5 26  SER n 
5 27  GLN n 
5 28  SER n 
5 29  VAL n 
5 30  LEU n 
5 31  TYR n 
5 32  SER n 
5 33  SER n 
5 34  ILE n 
5 35  ASN n 
5 36  LYS n 
5 37  ASN n 
5 38  TYR n 
5 39  LEU n 
5 40  ALA n 
5 41  TRP n 
5 42  TYR n 
5 43  GLN n 
5 44  GLN n 
5 45  LYS n 
5 46  PRO n 
5 47  GLY n 
5 48  GLN n 
5 49  PRO n 
5 50  PRO n 
5 51  LYS n 
5 52  LEU n 
5 53  LEU n 
5 54  ILE n 
5 55  TYR n 
5 56  TRP n 
5 57  ALA n 
5 58  SER n 
5 59  THR n 
5 60  ARG n 
5 61  GLU n 
5 62  SER n 
5 63  GLY n 
5 64  VAL n 
5 65  PRO n 
5 66  ASP n 
5 67  ARG n 
5 68  PHE n 
5 69  SER n 
5 70  GLY n 
5 71  SER n 
5 72  GLY n 
5 73  SER n 
5 74  GLY n 
5 75  THR n 
5 76  ASP n 
5 77  PHE n 
5 78  THR n 
5 79  LEU n 
5 80  THR n 
5 81  ILE n 
5 82  SER n 
5 83  SER n 
5 84  LEU n 
5 85  GLN n 
5 86  ALA n 
5 87  GLU n 
5 88  ASP n 
5 89  VAL n 
5 90  ALA n 
5 91  VAL n 
5 92  TYR n 
5 93  TYR n 
5 94  CYS n 
5 95  GLN n 
5 96  GLN n 
5 97  TYR n 
5 98  TYR n 
5 99  SER n 
5 100 THR n 
5 101 PRO n 
5 102 TYR n 
5 103 THR n 
5 104 PHE n 
5 105 GLY n 
5 106 GLN n 
5 107 GLY n 
5 108 THR n 
5 109 LYS n 
5 110 VAL n 
5 111 GLU n 
5 112 ILE n 
5 113 LYS n 
5 114 ARG n 
5 115 THR n 
5 116 VAL n 
5 117 ALA n 
5 118 ALA n 
5 119 PRO n 
5 120 SER n 
5 121 VAL n 
5 122 PHE n 
5 123 ILE n 
5 124 PHE n 
5 125 PRO n 
5 126 PRO n 
5 127 SER n 
5 128 ASP n 
5 129 GLU n 
5 130 GLN n 
5 131 LEU n 
5 132 LYS n 
5 133 SER n 
5 134 GLY n 
5 135 THR n 
5 136 ALA n 
5 137 SER n 
5 138 VAL n 
5 139 VAL n 
5 140 CYS n 
5 141 LEU n 
5 142 LEU n 
5 143 ASN n 
5 144 ASN n 
5 145 PHE n 
5 146 TYR n 
5 147 PRO n 
5 148 ARG n 
5 149 GLU n 
5 150 ALA n 
5 151 LYS n 
5 152 VAL n 
5 153 GLN n 
5 154 TRP n 
5 155 LYS n 
5 156 VAL n 
5 157 ASP n 
5 158 ASN n 
5 159 ALA n 
5 160 LEU n 
5 161 GLN n 
5 162 SER n 
5 163 GLY n 
5 164 ASN n 
5 165 SER n 
5 166 GLN n 
5 167 GLU n 
5 168 SER n 
5 169 VAL n 
5 170 THR n 
5 171 GLU n 
5 172 GLN n 
5 173 ASP n 
5 174 SER n 
5 175 LYS n 
5 176 ASP n 
5 177 SER n 
5 178 THR n 
5 179 TYR n 
5 180 SER n 
5 181 LEU n 
5 182 SER n 
5 183 SER n 
5 184 THR n 
5 185 LEU n 
5 186 THR n 
5 187 LEU n 
5 188 SER n 
5 189 LYS n 
5 190 ALA n 
5 191 ASP n 
5 192 TYR n 
5 193 GLU n 
5 194 LYS n 
5 195 HIS n 
5 196 LYS n 
5 197 VAL n 
5 198 TYR n 
5 199 ALA n 
5 200 CYS n 
5 201 GLU n 
5 202 VAL n 
5 203 THR n 
5 204 HIS n 
5 205 GLN n 
5 206 GLY n 
5 207 LEU n 
5 208 SER n 
5 209 SER n 
5 210 PRO n 
5 211 VAL n 
5 212 THR n 
5 213 LYS n 
5 214 SER n 
5 215 PHE n 
5 216 ASN n 
5 217 ARG n 
5 218 GLY n 
5 219 GLU n 
5 220 CYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 205 ? ? ? ? ? ? ? ? ? 'Severe acute respiratory syndrome coronavirus 2' 2697049 ? ? ? ? ? ? ? ? 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 220 ? ? ? ? ? ? ? ? ? 'Homo sapiens'                                    9606    ? ? ? ? ? ? ? ? 
'Homo sapiens'          9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 214 ? ? ? ? ? ? ? ? ? 'Homo sapiens'                                    9606    ? ? ? ? ? ? ? ? 
'Homo sapiens'          9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
4 1 sample 'Biological sequence' 1 222 ? ? ? ? ? ? ? ? ? 'Mus musculus'                                    10090   ? ? ? ? ? ? ? ? 
'Homo sapiens'          9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
5 1 sample 'Biological sequence' 1 220 ? ? ? ? ? ? ? ? ? 'Mus musculus'                                    10090   ? ? ? ? ? ? ? ? 
'Homo sapiens'          9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   6 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 6 DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-ROH                                          'Glycam Condensed Sequence' GMML       1.0   
2 6 'WURCS=2.0/2,3,2/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5]/1-1-2/a4-b1_b4-c1' WURCS                       PDB2Glycan 1.1.0 
3 6 '[][D-1-deoxy-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{}}}'           LINUCS                      PDB-CARE   ?     
# 
loop_
_pdbx_entity_branch_link.link_id 
_pdbx_entity_branch_link.entity_id 
_pdbx_entity_branch_link.entity_branch_list_num_1 
_pdbx_entity_branch_link.comp_id_1 
_pdbx_entity_branch_link.atom_id_1 
_pdbx_entity_branch_link.leaving_atom_id_1 
_pdbx_entity_branch_link.entity_branch_list_num_2 
_pdbx_entity_branch_link.comp_id_2 
_pdbx_entity_branch_link.atom_id_2 
_pdbx_entity_branch_link.leaving_atom_id_2 
_pdbx_entity_branch_link.value_order 
_pdbx_entity_branch_link.details 
1 6 2 NAG C1 O1 1 NAG O4 HO4 sing ? 
2 6 3 BMA C1 O1 2 NAG O4 HO4 sing ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'          y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'          y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'          y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'          y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
BMA 'D-saccharide, beta linking' . beta-D-mannopyranose                     'beta-D-mannose; D-mannose; mannose' 'C6 H12 O6'      
180.156 
CIT non-polymer                  . 'CITRIC ACID'                            ? 'C6 H8 O7'       192.124 
CYS 'L-peptide linking'          y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'          y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'          y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'            y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'          y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer                  . WATER                                    ? 'H2 O'           18.015  
ILE 'L-peptide linking'          y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'          y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'          y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking'          y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'          y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'          y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'          y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'          y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'          y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'          y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'          y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
BMA 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DManpb                         
BMA 'COMMON NAME'                         GMML     1.0 b-D-mannopyranose              
BMA 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Manp                       
BMA 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Man                            
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   THR 1   333 ?   ?   ?   A . n 
A 1 2   ASN 2   334 334 ASN ASN A . n 
A 1 3   LEU 3   335 335 LEU LEU A . n 
A 1 4   CYS 4   336 336 CYS CYS A . n 
A 1 5   PRO 5   337 337 PRO PRO A . n 
A 1 6   PHE 6   338 338 PHE PHE A . n 
A 1 7   GLY 7   339 339 GLY GLY A . n 
A 1 8   GLU 8   340 340 GLU GLU A . n 
A 1 9   VAL 9   341 341 VAL VAL A . n 
A 1 10  PHE 10  342 342 PHE PHE A . n 
A 1 11  ASN 11  343 343 ASN ASN A . n 
A 1 12  ALA 12  344 344 ALA ALA A . n 
A 1 13  THR 13  345 345 THR THR A . n 
A 1 14  ARG 14  346 346 ARG ARG A . n 
A 1 15  PHE 15  347 347 PHE PHE A . n 
A 1 16  ALA 16  348 348 ALA ALA A . n 
A 1 17  SER 17  349 349 SER SER A . n 
A 1 18  VAL 18  350 350 VAL VAL A . n 
A 1 19  TYR 19  351 351 TYR TYR A . n 
A 1 20  ALA 20  352 352 ALA ALA A . n 
A 1 21  TRP 21  353 353 TRP TRP A . n 
A 1 22  ASN 22  354 354 ASN ASN A . n 
A 1 23  ARG 23  355 355 ARG ARG A . n 
A 1 24  LYS 24  356 356 LYS LYS A . n 
A 1 25  ARG 25  357 357 ARG ARG A . n 
A 1 26  ILE 26  358 358 ILE ILE A . n 
A 1 27  SER 27  359 359 SER SER A . n 
A 1 28  ASN 28  360 360 ASN ASN A . n 
A 1 29  CYS 29  361 361 CYS CYS A . n 
A 1 30  VAL 30  362 362 VAL VAL A . n 
A 1 31  ALA 31  363 363 ALA ALA A . n 
A 1 32  ASP 32  364 364 ASP ASP A . n 
A 1 33  TYR 33  365 365 TYR TYR A . n 
A 1 34  SER 34  366 366 SER SER A . n 
A 1 35  VAL 35  367 367 VAL VAL A . n 
A 1 36  LEU 36  368 368 LEU LEU A . n 
A 1 37  TYR 37  369 369 TYR TYR A . n 
A 1 38  ASN 38  370 370 ASN ASN A . n 
A 1 39  SER 39  371 371 SER SER A . n 
A 1 40  ALA 40  372 372 ALA ALA A . n 
A 1 41  SER 41  373 373 SER SER A . n 
A 1 42  PHE 42  374 374 PHE PHE A . n 
A 1 43  SER 43  375 375 SER SER A . n 
A 1 44  THR 44  376 376 THR THR A . n 
A 1 45  PHE 45  377 377 PHE PHE A . n 
A 1 46  LYS 46  378 378 LYS LYS A . n 
A 1 47  CYS 47  379 379 CYS CYS A . n 
A 1 48  TYR 48  380 380 TYR TYR A . n 
A 1 49  GLY 49  381 381 GLY GLY A . n 
A 1 50  VAL 50  382 382 VAL VAL A . n 
A 1 51  SER 51  383 383 SER SER A . n 
A 1 52  PRO 52  384 384 PRO PRO A . n 
A 1 53  THR 53  385 385 THR THR A . n 
A 1 54  LYS 54  386 386 LYS LYS A . n 
A 1 55  LEU 55  387 387 LEU LEU A . n 
A 1 56  ASN 56  388 388 ASN ASN A . n 
A 1 57  ASP 57  389 389 ASP ASP A . n 
A 1 58  LEU 58  390 390 LEU LEU A . n 
A 1 59  CYS 59  391 391 CYS CYS A . n 
A 1 60  PHE 60  392 392 PHE PHE A . n 
A 1 61  THR 61  393 393 THR THR A . n 
A 1 62  ASN 62  394 394 ASN ASN A . n 
A 1 63  VAL 63  395 395 VAL VAL A . n 
A 1 64  TYR 64  396 396 TYR TYR A . n 
A 1 65  ALA 65  397 397 ALA ALA A . n 
A 1 66  ASP 66  398 398 ASP ASP A . n 
A 1 67  SER 67  399 399 SER SER A . n 
A 1 68  PHE 68  400 400 PHE PHE A . n 
A 1 69  VAL 69  401 401 VAL VAL A . n 
A 1 70  ILE 70  402 402 ILE ILE A . n 
A 1 71  ARG 71  403 403 ARG ARG A . n 
A 1 72  GLY 72  404 404 GLY GLY A . n 
A 1 73  ASP 73  405 405 ASP ASP A . n 
A 1 74  GLU 74  406 406 GLU GLU A . n 
A 1 75  VAL 75  407 407 VAL VAL A . n 
A 1 76  ARG 76  408 408 ARG ARG A . n 
A 1 77  GLN 77  409 409 GLN GLN A . n 
A 1 78  ILE 78  410 410 ILE ILE A . n 
A 1 79  ALA 79  411 411 ALA ALA A . n 
A 1 80  PRO 80  412 412 PRO PRO A . n 
A 1 81  GLY 81  413 413 GLY GLY A . n 
A 1 82  GLN 82  414 414 GLN GLN A . n 
A 1 83  THR 83  415 415 THR THR A . n 
A 1 84  GLY 84  416 416 GLY GLY A . n 
A 1 85  LYS 85  417 417 LYS LYS A . n 
A 1 86  ILE 86  418 418 ILE ILE A . n 
A 1 87  ALA 87  419 419 ALA ALA A . n 
A 1 88  ASP 88  420 420 ASP ASP A . n 
A 1 89  TYR 89  421 421 TYR TYR A . n 
A 1 90  ASN 90  422 422 ASN ASN A . n 
A 1 91  TYR 91  423 423 TYR TYR A . n 
A 1 92  LYS 92  424 424 LYS LYS A . n 
A 1 93  LEU 93  425 425 LEU LEU A . n 
A 1 94  PRO 94  426 426 PRO PRO A . n 
A 1 95  ASP 95  427 427 ASP ASP A . n 
A 1 96  ASP 96  428 428 ASP ASP A . n 
A 1 97  PHE 97  429 429 PHE PHE A . n 
A 1 98  THR 98  430 430 THR THR A . n 
A 1 99  GLY 99  431 431 GLY GLY A . n 
A 1 100 CYS 100 432 432 CYS CYS A . n 
A 1 101 VAL 101 433 433 VAL VAL A . n 
A 1 102 ILE 102 434 434 ILE ILE A . n 
A 1 103 ALA 103 435 435 ALA ALA A . n 
A 1 104 TRP 104 436 436 TRP TRP A . n 
A 1 105 ASN 105 437 437 ASN ASN A . n 
A 1 106 SER 106 438 438 SER SER A . n 
A 1 107 ASN 107 439 439 ASN ASN A . n 
A 1 108 ASN 108 440 440 ASN ASN A . n 
A 1 109 LEU 109 441 441 LEU LEU A . n 
A 1 110 ASP 110 442 442 ASP ASP A . n 
A 1 111 SER 111 443 443 SER SER A . n 
A 1 112 LYS 112 444 444 LYS LYS A . n 
A 1 113 VAL 113 445 445 VAL VAL A . n 
A 1 114 GLY 114 446 446 GLY GLY A . n 
A 1 115 GLY 115 447 447 GLY GLY A . n 
A 1 116 ASN 116 448 448 ASN ASN A . n 
A 1 117 TYR 117 449 449 TYR TYR A . n 
A 1 118 ASN 118 450 450 ASN ASN A . n 
A 1 119 TYR 119 451 451 TYR TYR A . n 
A 1 120 LEU 120 452 452 LEU LEU A . n 
A 1 121 TYR 121 453 453 TYR TYR A . n 
A 1 122 ARG 122 454 454 ARG ARG A . n 
A 1 123 LEU 123 455 455 LEU LEU A . n 
A 1 124 PHE 124 456 456 PHE PHE A . n 
A 1 125 ARG 125 457 457 ARG ARG A . n 
A 1 126 LYS 126 458 458 LYS LYS A . n 
A 1 127 SER 127 459 459 SER SER A . n 
A 1 128 ASN 128 460 460 ASN ASN A . n 
A 1 129 LEU 129 461 461 LEU LEU A . n 
A 1 130 LYS 130 462 462 LYS LYS A . n 
A 1 131 PRO 131 463 463 PRO PRO A . n 
A 1 132 PHE 132 464 464 PHE PHE A . n 
A 1 133 GLU 133 465 465 GLU GLU A . n 
A 1 134 ARG 134 466 466 ARG ARG A . n 
A 1 135 ASP 135 467 467 ASP ASP A . n 
A 1 136 ILE 136 468 468 ILE ILE A . n 
A 1 137 SER 137 469 469 SER SER A . n 
A 1 138 THR 138 470 470 THR THR A . n 
A 1 139 GLU 139 471 471 GLU GLU A . n 
A 1 140 ILE 140 472 472 ILE ILE A . n 
A 1 141 TYR 141 473 473 TYR TYR A . n 
A 1 142 GLN 142 474 474 GLN GLN A . n 
A 1 143 ALA 143 475 475 ALA ALA A . n 
A 1 144 GLY 144 476 476 GLY GLY A . n 
A 1 145 SER 145 477 477 SER SER A . n 
A 1 146 THR 146 478 478 THR THR A . n 
A 1 147 PRO 147 479 479 PRO PRO A . n 
A 1 148 CYS 148 480 480 CYS CYS A . n 
A 1 149 ASN 149 481 481 ASN ASN A . n 
A 1 150 GLY 150 482 482 GLY GLY A . n 
A 1 151 VAL 151 483 483 VAL VAL A . n 
A 1 152 GLU 152 484 484 GLU GLU A . n 
A 1 153 GLY 153 485 485 GLY GLY A . n 
A 1 154 PHE 154 486 486 PHE PHE A . n 
A 1 155 ASN 155 487 487 ASN ASN A . n 
A 1 156 CYS 156 488 488 CYS CYS A . n 
A 1 157 TYR 157 489 489 TYR TYR A . n 
A 1 158 PHE 158 490 490 PHE PHE A . n 
A 1 159 PRO 159 491 491 PRO PRO A . n 
A 1 160 LEU 160 492 492 LEU LEU A . n 
A 1 161 GLN 161 493 493 GLN GLN A . n 
A 1 162 SER 162 494 494 SER SER A . n 
A 1 163 TYR 163 495 495 TYR TYR A . n 
A 1 164 GLY 164 496 496 GLY GLY A . n 
A 1 165 PHE 165 497 497 PHE PHE A . n 
A 1 166 GLN 166 498 498 GLN GLN A . n 
A 1 167 PRO 167 499 499 PRO PRO A . n 
A 1 168 THR 168 500 500 THR THR A . n 
A 1 169 ASN 169 501 501 ASN ASN A . n 
A 1 170 GLY 170 502 502 GLY GLY A . n 
A 1 171 VAL 171 503 503 VAL VAL A . n 
A 1 172 GLY 172 504 504 GLY GLY A . n 
A 1 173 TYR 173 505 505 TYR TYR A . n 
A 1 174 GLN 174 506 506 GLN GLN A . n 
A 1 175 PRO 175 507 507 PRO PRO A . n 
A 1 176 TYR 176 508 508 TYR TYR A . n 
A 1 177 ARG 177 509 509 ARG ARG A . n 
A 1 178 VAL 178 510 510 VAL VAL A . n 
A 1 179 VAL 179 511 511 VAL VAL A . n 
A 1 180 VAL 180 512 512 VAL VAL A . n 
A 1 181 LEU 181 513 513 LEU LEU A . n 
A 1 182 SER 182 514 514 SER SER A . n 
A 1 183 PHE 183 515 515 PHE PHE A . n 
A 1 184 GLU 184 516 516 GLU GLU A . n 
A 1 185 LEU 185 517 517 LEU LEU A . n 
A 1 186 LEU 186 518 ?   ?   ?   A . n 
A 1 187 HIS 187 519 ?   ?   ?   A . n 
A 1 188 ALA 188 520 520 ALA ALA A . n 
A 1 189 PRO 189 521 521 PRO PRO A . n 
A 1 190 ALA 190 522 522 ALA ALA A . n 
A 1 191 THR 191 523 523 THR THR A . n 
A 1 192 VAL 192 524 524 VAL VAL A . n 
A 1 193 CYS 193 525 525 CYS CYS A . n 
A 1 194 GLY 194 526 526 GLY GLY A . n 
A 1 195 PRO 195 527 527 PRO PRO A . n 
A 1 196 LYS 196 528 528 LYS LYS A . n 
A 1 197 LYS 197 529 ?   ?   ?   A . n 
A 1 198 SER 198 530 ?   ?   ?   A . n 
A 1 199 GLY 199 531 ?   ?   ?   A . n 
A 1 200 HIS 200 532 ?   ?   ?   A . n 
A 1 201 HIS 201 533 ?   ?   ?   A . n 
A 1 202 HIS 202 534 ?   ?   ?   A . n 
A 1 203 HIS 203 535 ?   ?   ?   A . n 
A 1 204 HIS 204 536 ?   ?   ?   A . n 
A 1 205 HIS 205 537 ?   ?   ?   A . n 
B 2 1   GLN 1   1   1   GLN GLN F . n 
B 2 2   VAL 2   2   2   VAL VAL F . n 
B 2 3   GLN 3   3   3   GLN GLN F . n 
B 2 4   LEU 4   4   4   LEU LEU F . n 
B 2 5   VAL 5   5   5   VAL VAL F . n 
B 2 6   GLU 6   6   6   GLU GLU F . n 
B 2 7   SER 7   7   7   SER SER F . n 
B 2 8   GLY 8   8   8   GLY GLY F . n 
B 2 9   GLY 9   9   9   GLY GLY F . n 
B 2 10  GLY 10  10  10  GLY GLY F . n 
B 2 11  LEU 11  11  11  LEU LEU F . n 
B 2 12  ILE 12  12  12  ILE ILE F . n 
B 2 13  GLN 13  13  13  GLN GLN F . n 
B 2 14  PRO 14  14  14  PRO PRO F . n 
B 2 15  GLY 15  15  15  GLY GLY F . n 
B 2 16  GLY 16  16  16  GLY GLY F . n 
B 2 17  SER 17  17  17  SER SER F . n 
B 2 18  LEU 18  18  18  LEU LEU F . n 
B 2 19  ARG 19  19  19  ARG ARG F . n 
B 2 20  LEU 20  20  20  LEU LEU F . n 
B 2 21  SER 21  21  21  SER SER F . n 
B 2 22  CYS 22  22  22  CYS CYS F . n 
B 2 23  ALA 23  23  23  ALA ALA F . n 
B 2 24  ALA 24  24  24  ALA ALA F . n 
B 2 25  SER 25  25  25  SER SER F . n 
B 2 26  GLY 26  26  26  GLY GLY F . n 
B 2 27  PHE 27  27  27  PHE PHE F . n 
B 2 28  THR 28  28  28  THR THR F . n 
B 2 29  VAL 29  29  29  VAL VAL F . n 
B 2 30  SER 30  30  30  SER SER F . n 
B 2 31  SER 31  31  31  SER SER F . n 
B 2 32  ASN 32  32  32  ASN ASN F . n 
B 2 33  TYR 33  33  33  TYR TYR F . n 
B 2 34  MET 34  34  34  MET MET F . n 
B 2 35  SER 35  35  35  SER SER F . n 
B 2 36  TRP 36  36  36  TRP TRP F . n 
B 2 37  VAL 37  37  37  VAL VAL F . n 
B 2 38  ARG 38  38  38  ARG ARG F . n 
B 2 39  GLN 39  39  39  GLN GLN F . n 
B 2 40  ALA 40  40  40  ALA ALA F . n 
B 2 41  PRO 41  41  41  PRO PRO F . n 
B 2 42  GLY 42  42  42  GLY GLY F . n 
B 2 43  LYS 43  43  43  LYS LYS F . n 
B 2 44  GLY 44  44  44  GLY GLY F . n 
B 2 45  LEU 45  45  45  LEU LEU F . n 
B 2 46  GLU 46  46  46  GLU GLU F . n 
B 2 47  TRP 47  47  47  TRP TRP F . n 
B 2 48  VAL 48  48  48  VAL VAL F . n 
B 2 49  SER 49  49  49  SER SER F . n 
B 2 50  VAL 50  50  50  VAL VAL F . n 
B 2 51  ILE 51  51  51  ILE ILE F . n 
B 2 52  TYR 52  52  52  TYR TYR F . n 
B 2 53  SER 53  53  53  SER SER F . n 
B 2 54  GLY 54  54  54  GLY GLY F . n 
B 2 55  GLY 55  55  55  GLY GLY F . n 
B 2 56  SER 56  56  56  SER SER F . n 
B 2 57  THR 57  57  57  THR THR F . n 
B 2 58  PHE 58  58  58  PHE PHE F . n 
B 2 59  TYR 59  59  59  TYR TYR F . n 
B 2 60  ALA 60  60  60  ALA ALA F . n 
B 2 61  ASP 61  61  61  ASP ASP F . n 
B 2 62  SER 62  62  62  SER SER F . n 
B 2 63  VAL 63  63  63  VAL VAL F . n 
B 2 64  LYS 64  64  64  LYS LYS F . n 
B 2 65  GLY 65  65  65  GLY GLY F . n 
B 2 66  ARG 66  66  66  ARG ARG F . n 
B 2 67  PHE 67  67  67  PHE PHE F . n 
B 2 68  THR 68  68  68  THR THR F . n 
B 2 69  ILE 69  69  69  ILE ILE F . n 
B 2 70  SER 70  70  70  SER SER F . n 
B 2 71  ARG 71  71  71  ARG ARG F . n 
B 2 72  ASP 72  72  72  ASP ASP F . n 
B 2 73  ASN 73  73  73  ASN ASN F . n 
B 2 74  SER 74  74  74  SER SER F . n 
B 2 75  LYS 75  75  75  LYS LYS F . n 
B 2 76  SER 76  76  76  SER SER F . n 
B 2 77  THR 77  77  77  THR THR F . n 
B 2 78  LEU 78  78  78  LEU LEU F . n 
B 2 79  TYR 79  79  79  TYR TYR F . n 
B 2 80  LEU 80  80  80  LEU LEU F . n 
B 2 81  GLN 81  81  81  GLN GLN F . n 
B 2 82  MET 82  82  82  MET MET F . n 
B 2 83  ASN 83  82  82  ASN ASN F A n 
B 2 84  SER 84  82  82  SER SER F B n 
B 2 85  LEU 85  82  82  LEU LEU F C n 
B 2 86  ARG 86  83  83  ARG ARG F . n 
B 2 87  VAL 87  84  84  VAL VAL F . n 
B 2 88  GLU 88  85  85  GLU GLU F . n 
B 2 89  ASP 89  86  86  ASP ASP F . n 
B 2 90  THR 90  87  87  THR THR F . n 
B 2 91  ALA 91  88  88  ALA ALA F . n 
B 2 92  VAL 92  89  89  VAL VAL F . n 
B 2 93  TYR 93  90  90  TYR TYR F . n 
B 2 94  TYR 94  91  91  TYR TYR F . n 
B 2 95  CYS 95  92  92  CYS CYS F . n 
B 2 96  ALA 96  93  93  ALA ALA F . n 
B 2 97  ARG 97  94  94  ARG ARG F . n 
B 2 98  ASP 98  95  95  ASP ASP F . n 
B 2 99  PHE 99  96  96  PHE PHE F . n 
B 2 100 GLY 100 97  97  GLY GLY F . n 
B 2 101 ASP 101 98  98  ASP ASP F . n 
B 2 102 PHE 102 99  99  PHE PHE F . n 
B 2 103 TYR 103 100 100 TYR TYR F . n 
B 2 104 PHE 104 100 100 PHE PHE F A n 
B 2 105 ASP 105 101 101 ASP ASP F . n 
B 2 106 TYR 106 102 102 TYR TYR F . n 
B 2 107 TRP 107 103 103 TRP TRP F . n 
B 2 108 GLY 108 104 104 GLY GLY F . n 
B 2 109 GLN 109 105 105 GLN GLN F . n 
B 2 110 GLY 110 106 106 GLY GLY F . n 
B 2 111 THR 111 107 107 THR THR F . n 
B 2 112 LEU 112 108 108 LEU LEU F . n 
B 2 113 VAL 113 109 109 VAL VAL F . n 
B 2 114 THR 114 110 110 THR THR F . n 
B 2 115 VAL 115 111 111 VAL VAL F . n 
B 2 116 SER 116 112 112 SER SER F . n 
B 2 117 SER 117 113 113 SER SER F . n 
B 2 118 ALA 118 114 114 ALA ALA F . n 
B 2 119 SER 119 115 115 SER SER F . n 
B 2 120 THR 120 116 116 THR THR F . n 
B 2 121 LYS 121 117 117 LYS LYS F . n 
B 2 122 GLY 122 118 118 GLY GLY F . n 
B 2 123 PRO 123 119 119 PRO PRO F . n 
B 2 124 SER 124 120 120 SER SER F . n 
B 2 125 VAL 125 121 121 VAL VAL F . n 
B 2 126 PHE 126 122 122 PHE PHE F . n 
B 2 127 PRO 127 123 123 PRO PRO F . n 
B 2 128 LEU 128 124 124 LEU LEU F . n 
B 2 129 ALA 129 125 125 ALA ALA F . n 
B 2 130 PRO 130 126 126 PRO PRO F . n 
B 2 131 SER 131 127 127 SER SER F . n 
B 2 132 SER 132 128 128 SER SER F . n 
B 2 133 LYS 133 129 129 LYS LYS F . n 
B 2 134 SER 134 130 130 SER SER F . n 
B 2 135 THR 135 131 131 THR THR F . n 
B 2 136 SER 136 132 132 SER SER F . n 
B 2 137 GLY 137 133 133 GLY GLY F . n 
B 2 138 GLY 138 134 134 GLY GLY F . n 
B 2 139 THR 139 135 135 THR THR F . n 
B 2 140 ALA 140 136 136 ALA ALA F . n 
B 2 141 ALA 141 137 137 ALA ALA F . n 
B 2 142 LEU 142 138 138 LEU LEU F . n 
B 2 143 GLY 143 139 139 GLY GLY F . n 
B 2 144 CYS 144 140 140 CYS CYS F . n 
B 2 145 LEU 145 141 141 LEU LEU F . n 
B 2 146 VAL 146 142 142 VAL VAL F . n 
B 2 147 LYS 147 143 143 LYS LYS F . n 
B 2 148 ASP 148 144 144 ASP ASP F . n 
B 2 149 TYR 149 145 145 TYR TYR F . n 
B 2 150 PHE 150 146 146 PHE PHE F . n 
B 2 151 PRO 151 147 147 PRO PRO F . n 
B 2 152 GLU 152 148 148 GLU GLU F . n 
B 2 153 PRO 153 149 149 PRO PRO F . n 
B 2 154 VAL 154 150 150 VAL VAL F . n 
B 2 155 THR 155 151 151 THR THR F . n 
B 2 156 VAL 156 152 152 VAL VAL F . n 
B 2 157 SER 157 153 153 SER SER F . n 
B 2 158 TRP 158 154 154 TRP TRP F . n 
B 2 159 ASN 159 155 155 ASN ASN F . n 
B 2 160 SER 160 156 156 SER SER F . n 
B 2 161 GLY 161 157 157 GLY GLY F . n 
B 2 162 ALA 162 158 158 ALA ALA F . n 
B 2 163 LEU 163 159 159 LEU LEU F . n 
B 2 164 THR 164 160 160 THR THR F . n 
B 2 165 SER 165 161 161 SER SER F . n 
B 2 166 GLY 166 162 162 GLY GLY F . n 
B 2 167 VAL 167 163 163 VAL VAL F . n 
B 2 168 HIS 168 164 164 HIS HIS F . n 
B 2 169 THR 169 165 165 THR THR F . n 
B 2 170 PHE 170 166 166 PHE PHE F . n 
B 2 171 PRO 171 167 167 PRO PRO F . n 
B 2 172 ALA 172 168 168 ALA ALA F . n 
B 2 173 VAL 173 169 169 VAL VAL F . n 
B 2 174 LEU 174 170 170 LEU LEU F . n 
B 2 175 GLN 175 171 171 GLN GLN F . n 
B 2 176 SER 176 172 172 SER SER F . n 
B 2 177 SER 177 173 173 SER SER F . n 
B 2 178 GLY 178 174 174 GLY GLY F . n 
B 2 179 LEU 179 175 175 LEU LEU F . n 
B 2 180 TYR 180 176 176 TYR TYR F . n 
B 2 181 SER 181 177 177 SER SER F . n 
B 2 182 LEU 182 178 178 LEU LEU F . n 
B 2 183 SER 183 179 179 SER SER F . n 
B 2 184 SER 184 180 180 SER SER F . n 
B 2 185 VAL 185 181 181 VAL VAL F . n 
B 2 186 VAL 186 182 182 VAL VAL F . n 
B 2 187 THR 187 183 183 THR THR F . n 
B 2 188 VAL 188 184 184 VAL VAL F . n 
B 2 189 PRO 189 185 185 PRO PRO F . n 
B 2 190 SER 190 186 186 SER SER F . n 
B 2 191 SER 191 187 187 SER SER F . n 
B 2 192 SER 192 188 188 SER SER F . n 
B 2 193 LEU 193 189 189 LEU LEU F . n 
B 2 194 GLY 194 190 190 GLY GLY F . n 
B 2 195 THR 195 191 191 THR THR F . n 
B 2 196 GLN 196 192 192 GLN GLN F . n 
B 2 197 THR 197 193 193 THR THR F . n 
B 2 198 TYR 198 194 194 TYR TYR F . n 
B 2 199 ILE 199 195 195 ILE ILE F . n 
B 2 200 CYS 200 196 196 CYS CYS F . n 
B 2 201 ASN 201 197 197 ASN ASN F . n 
B 2 202 VAL 202 198 198 VAL VAL F . n 
B 2 203 ASN 203 199 199 ASN ASN F . n 
B 2 204 HIS 204 200 200 HIS HIS F . n 
B 2 205 LYS 205 201 201 LYS LYS F . n 
B 2 206 PRO 206 202 202 PRO PRO F . n 
B 2 207 SER 207 203 203 SER SER F . n 
B 2 208 ASN 208 204 204 ASN ASN F . n 
B 2 209 THR 209 205 205 THR THR F . n 
B 2 210 LYS 210 206 206 LYS LYS F . n 
B 2 211 VAL 211 207 207 VAL VAL F . n 
B 2 212 ASP 212 208 208 ASP ASP F . n 
B 2 213 LYS 213 209 209 LYS LYS F . n 
B 2 214 LYS 214 210 210 LYS LYS F . n 
B 2 215 VAL 215 211 211 VAL VAL F . n 
B 2 216 GLU 216 212 212 GLU GLU F . n 
B 2 217 PRO 217 213 213 PRO PRO F . n 
B 2 218 LYS 218 214 214 LYS LYS F . n 
B 2 219 SER 219 215 ?   ?   ?   F . n 
B 2 220 CYS 220 216 ?   ?   ?   F . n 
C 3 1   GLU 1   1   1   GLU GLU G . n 
C 3 2   ILE 2   2   2   ILE ILE G . n 
C 3 3   VAL 3   3   3   VAL VAL G . n 
C 3 4   LEU 4   4   4   LEU LEU G . n 
C 3 5   THR 5   5   5   THR THR G . n 
C 3 6   GLN 6   6   6   GLN GLN G . n 
C 3 7   SER 7   7   7   SER SER G . n 
C 3 8   PRO 8   8   8   PRO PRO G . n 
C 3 9   GLY 9   9   9   GLY GLY G . n 
C 3 10  THR 10  10  10  THR THR G . n 
C 3 11  LEU 11  11  11  LEU LEU G . n 
C 3 12  SER 12  12  12  SER SER G . n 
C 3 13  LEU 13  13  13  LEU LEU G . n 
C 3 14  SER 14  14  14  SER SER G . n 
C 3 15  PRO 15  15  15  PRO PRO G . n 
C 3 16  GLY 16  16  16  GLY GLY G . n 
C 3 17  GLU 17  17  17  GLU GLU G . n 
C 3 18  ARG 18  18  18  ARG ARG G . n 
C 3 19  ALA 19  19  19  ALA ALA G . n 
C 3 20  THR 20  20  20  THR THR G . n 
C 3 21  LEU 21  21  21  LEU LEU G . n 
C 3 22  SER 22  22  22  SER SER G . n 
C 3 23  CYS 23  23  23  CYS CYS G . n 
C 3 24  ARG 24  24  24  ARG ARG G . n 
C 3 25  ALA 25  25  25  ALA ALA G . n 
C 3 26  SER 26  26  26  SER SER G . n 
C 3 27  GLN 27  27  27  GLN GLN G . n 
C 3 28  SER 28  28  28  SER SER G . n 
C 3 29  VAL 29  29  29  VAL VAL G . n 
C 3 30  SER 30  30  30  SER SER G . n 
C 3 31  SER 31  31  31  SER SER G . n 
C 3 32  TYR 32  32  32  TYR TYR G . n 
C 3 33  LEU 33  33  33  LEU LEU G . n 
C 3 34  ALA 34  34  34  ALA ALA G . n 
C 3 35  TRP 35  35  35  TRP TRP G . n 
C 3 36  TYR 36  36  36  TYR TYR G . n 
C 3 37  GLN 37  37  37  GLN GLN G . n 
C 3 38  GLN 38  38  38  GLN GLN G . n 
C 3 39  LYS 39  39  39  LYS LYS G . n 
C 3 40  PRO 40  40  40  PRO PRO G . n 
C 3 41  GLY 41  41  41  GLY GLY G . n 
C 3 42  GLN 42  42  42  GLN GLN G . n 
C 3 43  ALA 43  43  43  ALA ALA G . n 
C 3 44  PRO 44  44  44  PRO PRO G . n 
C 3 45  ARG 45  45  45  ARG ARG G . n 
C 3 46  LEU 46  46  46  LEU LEU G . n 
C 3 47  LEU 47  47  47  LEU LEU G . n 
C 3 48  ILE 48  48  48  ILE ILE G . n 
C 3 49  TYR 49  49  49  TYR TYR G . n 
C 3 50  GLY 50  50  50  GLY GLY G . n 
C 3 51  ALA 51  51  51  ALA ALA G . n 
C 3 52  SER 52  52  52  SER SER G . n 
C 3 53  SER 53  53  53  SER SER G . n 
C 3 54  ARG 54  54  54  ARG ARG G . n 
C 3 55  ALA 55  55  55  ALA ALA G . n 
C 3 56  THR 56  56  56  THR THR G . n 
C 3 57  GLY 57  57  57  GLY GLY G . n 
C 3 58  ILE 58  58  58  ILE ILE G . n 
C 3 59  PRO 59  59  59  PRO PRO G . n 
C 3 60  ASP 60  60  60  ASP ASP G . n 
C 3 61  ARG 61  61  61  ARG ARG G . n 
C 3 62  PHE 62  62  62  PHE PHE G . n 
C 3 63  SER 63  63  63  SER SER G . n 
C 3 64  GLY 64  64  64  GLY GLY G . n 
C 3 65  SER 65  65  65  SER SER G . n 
C 3 66  GLY 66  66  66  GLY GLY G . n 
C 3 67  SER 67  67  67  SER SER G . n 
C 3 68  GLY 68  68  68  GLY GLY G . n 
C 3 69  THR 69  69  69  THR THR G . n 
C 3 70  ASP 70  70  70  ASP ASP G . n 
C 3 71  PHE 71  71  71  PHE PHE G . n 
C 3 72  THR 72  72  72  THR THR G . n 
C 3 73  LEU 73  73  73  LEU LEU G . n 
C 3 74  THR 74  74  74  THR THR G . n 
C 3 75  ILE 75  75  75  ILE ILE G . n 
C 3 76  SER 76  76  76  SER SER G . n 
C 3 77  ARG 77  77  77  ARG ARG G . n 
C 3 78  LEU 78  78  78  LEU LEU G . n 
C 3 79  GLU 79  79  79  GLU GLU G . n 
C 3 80  PRO 80  80  80  PRO PRO G . n 
C 3 81  GLU 81  81  81  GLU GLU G . n 
C 3 82  ASP 82  82  82  ASP ASP G . n 
C 3 83  PHE 83  83  83  PHE PHE G . n 
C 3 84  ALA 84  84  84  ALA ALA G . n 
C 3 85  VAL 85  85  85  VAL VAL G . n 
C 3 86  TYR 86  86  86  TYR TYR G . n 
C 3 87  TYR 87  87  87  TYR TYR G . n 
C 3 88  CYS 88  88  88  CYS CYS G . n 
C 3 89  GLN 89  89  89  GLN GLN G . n 
C 3 90  GLN 90  90  90  GLN GLN G . n 
C 3 91  TYR 91  91  91  TYR TYR G . n 
C 3 92  GLY 92  92  92  GLY GLY G . n 
C 3 93  SER 93  93  93  SER SER G . n 
C 3 94  SER 94  94  94  SER SER G . n 
C 3 95  PRO 95  95  95  PRO PRO G . n 
C 3 96  ARG 96  96  96  ARG ARG G . n 
C 3 97  THR 97  97  97  THR THR G . n 
C 3 98  PHE 98  98  98  PHE PHE G . n 
C 3 99  GLY 99  99  99  GLY GLY G . n 
C 3 100 GLN 100 100 100 GLN GLN G . n 
C 3 101 GLY 101 101 101 GLY GLY G . n 
C 3 102 THR 102 102 102 THR THR G . n 
C 3 103 LYS 103 103 103 LYS LYS G . n 
C 3 104 LEU 104 104 104 LEU LEU G . n 
C 3 105 GLU 105 105 105 GLU GLU G . n 
C 3 106 ILE 106 106 106 ILE ILE G . n 
C 3 107 LYS 107 107 107 LYS LYS G . n 
C 3 108 ARG 108 108 108 ARG ARG G . n 
C 3 109 THR 109 109 109 THR THR G . n 
C 3 110 VAL 110 110 110 VAL VAL G . n 
C 3 111 ALA 111 111 111 ALA ALA G . n 
C 3 112 ALA 112 112 112 ALA ALA G . n 
C 3 113 PRO 113 113 113 PRO PRO G . n 
C 3 114 SER 114 114 114 SER SER G . n 
C 3 115 VAL 115 115 115 VAL VAL G . n 
C 3 116 PHE 116 116 116 PHE PHE G . n 
C 3 117 ILE 117 117 117 ILE ILE G . n 
C 3 118 PHE 118 118 118 PHE PHE G . n 
C 3 119 PRO 119 119 119 PRO PRO G . n 
C 3 120 PRO 120 120 120 PRO PRO G . n 
C 3 121 SER 121 121 121 SER SER G . n 
C 3 122 ASP 122 122 122 ASP ASP G . n 
C 3 123 GLU 123 123 123 GLU GLU G . n 
C 3 124 GLN 124 124 124 GLN GLN G . n 
C 3 125 LEU 125 125 125 LEU LEU G . n 
C 3 126 LYS 126 126 126 LYS LYS G . n 
C 3 127 SER 127 127 127 SER SER G . n 
C 3 128 GLY 128 128 128 GLY GLY G . n 
C 3 129 THR 129 129 129 THR THR G . n 
C 3 130 ALA 130 130 130 ALA ALA G . n 
C 3 131 SER 131 131 131 SER SER G . n 
C 3 132 VAL 132 132 132 VAL VAL G . n 
C 3 133 VAL 133 133 133 VAL VAL G . n 
C 3 134 CYS 134 134 134 CYS CYS G . n 
C 3 135 LEU 135 135 135 LEU LEU G . n 
C 3 136 LEU 136 136 136 LEU LEU G . n 
C 3 137 ASN 137 137 137 ASN ASN G . n 
C 3 138 ASN 138 138 138 ASN ASN G . n 
C 3 139 PHE 139 139 139 PHE PHE G . n 
C 3 140 TYR 140 140 140 TYR TYR G . n 
C 3 141 PRO 141 141 141 PRO PRO G . n 
C 3 142 ARG 142 142 142 ARG ARG G . n 
C 3 143 GLU 143 143 143 GLU GLU G . n 
C 3 144 ALA 144 144 144 ALA ALA G . n 
C 3 145 LYS 145 145 145 LYS LYS G . n 
C 3 146 VAL 146 146 146 VAL VAL G . n 
C 3 147 GLN 147 147 147 GLN GLN G . n 
C 3 148 TRP 148 148 148 TRP TRP G . n 
C 3 149 LYS 149 149 149 LYS LYS G . n 
C 3 150 VAL 150 150 150 VAL VAL G . n 
C 3 151 ASP 151 151 151 ASP ASP G . n 
C 3 152 ASN 152 152 152 ASN ASN G . n 
C 3 153 ALA 153 153 153 ALA ALA G . n 
C 3 154 LEU 154 154 154 LEU LEU G . n 
C 3 155 GLN 155 155 155 GLN GLN G . n 
C 3 156 SER 156 156 156 SER SER G . n 
C 3 157 GLY 157 157 157 GLY GLY G . n 
C 3 158 ASN 158 158 158 ASN ASN G . n 
C 3 159 SER 159 159 159 SER SER G . n 
C 3 160 GLN 160 160 160 GLN GLN G . n 
C 3 161 GLU 161 161 161 GLU GLU G . n 
C 3 162 SER 162 162 162 SER SER G . n 
C 3 163 VAL 163 163 163 VAL VAL G . n 
C 3 164 THR 164 164 164 THR THR G . n 
C 3 165 GLU 165 165 165 GLU GLU G . n 
C 3 166 GLN 166 166 166 GLN GLN G . n 
C 3 167 ASP 167 167 167 ASP ASP G . n 
C 3 168 SER 168 168 168 SER SER G . n 
C 3 169 LYS 169 169 169 LYS LYS G . n 
C 3 170 ASP 170 170 170 ASP ASP G . n 
C 3 171 SER 171 171 171 SER SER G . n 
C 3 172 THR 172 172 172 THR THR G . n 
C 3 173 TYR 173 173 173 TYR TYR G . n 
C 3 174 SER 174 174 174 SER SER G . n 
C 3 175 LEU 175 175 175 LEU LEU G . n 
C 3 176 SER 176 176 176 SER SER G . n 
C 3 177 SER 177 177 177 SER SER G . n 
C 3 178 THR 178 178 178 THR THR G . n 
C 3 179 LEU 179 179 179 LEU LEU G . n 
C 3 180 THR 180 180 180 THR THR G . n 
C 3 181 LEU 181 181 181 LEU LEU G . n 
C 3 182 SER 182 182 182 SER SER G . n 
C 3 183 LYS 183 183 183 LYS LYS G . n 
C 3 184 ALA 184 184 184 ALA ALA G . n 
C 3 185 ASP 185 185 185 ASP ASP G . n 
C 3 186 TYR 186 186 186 TYR TYR G . n 
C 3 187 GLU 187 187 187 GLU GLU G . n 
C 3 188 LYS 188 188 188 LYS LYS G . n 
C 3 189 HIS 189 189 189 HIS HIS G . n 
C 3 190 LYS 190 190 190 LYS LYS G . n 
C 3 191 VAL 191 191 191 VAL VAL G . n 
C 3 192 TYR 192 192 192 TYR TYR G . n 
C 3 193 ALA 193 193 193 ALA ALA G . n 
C 3 194 CYS 194 194 194 CYS CYS G . n 
C 3 195 GLU 195 195 195 GLU GLU G . n 
C 3 196 VAL 196 196 196 VAL VAL G . n 
C 3 197 THR 197 197 197 THR THR G . n 
C 3 198 HIS 198 198 198 HIS HIS G . n 
C 3 199 GLN 199 199 199 GLN GLN G . n 
C 3 200 GLY 200 200 200 GLY GLY G . n 
C 3 201 LEU 201 201 201 LEU LEU G . n 
C 3 202 SER 202 202 202 SER SER G . n 
C 3 203 SER 203 203 203 SER SER G . n 
C 3 204 PRO 204 204 204 PRO PRO G . n 
C 3 205 VAL 205 205 205 VAL VAL G . n 
C 3 206 THR 206 206 206 THR THR G . n 
C 3 207 LYS 207 207 207 LYS LYS G . n 
C 3 208 SER 208 208 208 SER SER G . n 
C 3 209 PHE 209 209 209 PHE PHE G . n 
C 3 210 ASN 210 210 210 ASN ASN G . n 
C 3 211 ARG 211 211 211 ARG ARG G . n 
C 3 212 GLY 212 212 212 GLY GLY G . n 
C 3 213 GLU 213 213 ?   ?   ?   G . n 
C 3 214 CYS 214 214 ?   ?   ?   G . n 
D 4 1   GLN 1   1   1   GLN GLN H . n 
D 4 2   MET 2   2   2   MET MET H . n 
D 4 3   GLN 3   3   3   GLN GLN H . n 
D 4 4   LEU 4   4   4   LEU LEU H . n 
D 4 5   VAL 5   5   5   VAL VAL H . n 
D 4 6   GLN 6   6   6   GLN GLN H . n 
D 4 7   SER 7   7   7   SER SER H . n 
D 4 8   GLY 8   8   8   GLY GLY H . n 
D 4 9   THR 9   9   9   THR THR H . n 
D 4 10  GLU 10  10  10  GLU GLU H . n 
D 4 11  VAL 11  11  11  VAL VAL H . n 
D 4 12  LYS 12  12  12  LYS LYS H . n 
D 4 13  LYS 13  13  13  LYS LYS H . n 
D 4 14  PRO 14  14  14  PRO PRO H . n 
D 4 15  GLY 15  15  15  GLY GLY H . n 
D 4 16  GLU 16  16  16  GLU GLU H . n 
D 4 17  SER 17  17  17  SER SER H . n 
D 4 18  LEU 18  18  18  LEU LEU H . n 
D 4 19  LYS 19  19  19  LYS LYS H . n 
D 4 20  ILE 20  20  20  ILE ILE H . n 
D 4 21  SER 21  21  21  SER SER H . n 
D 4 22  CYS 22  22  22  CYS CYS H . n 
D 4 23  LYS 23  23  23  LYS LYS H . n 
D 4 24  GLY 24  24  24  GLY GLY H . n 
D 4 25  SER 25  25  25  SER SER H . n 
D 4 26  GLY 26  26  26  GLY GLY H . n 
D 4 27  TYR 27  27  27  TYR TYR H . n 
D 4 28  GLY 28  28  28  GLY GLY H . n 
D 4 29  LEU 29  29  29  LEU LEU H . n 
D 4 30  ILE 30  30  30  ILE ILE H . n 
D 4 31  THR 31  31  31  THR THR H . n 
D 4 32  TYR 32  32  32  TYR TYR H . n 
D 4 33  TRP 33  33  33  TRP TRP H . n 
D 4 34  ILE 34  34  34  ILE ILE H . n 
D 4 35  GLY 35  35  35  GLY GLY H . n 
D 4 36  TRP 36  36  36  TRP TRP H . n 
D 4 37  VAL 37  37  37  VAL VAL H . n 
D 4 38  ARG 38  38  38  ARG ARG H . n 
D 4 39  GLN 39  39  39  GLN GLN H . n 
D 4 40  MET 40  40  40  MET MET H . n 
D 4 41  SER 41  41  41  SER SER H . n 
D 4 42  GLY 42  42  42  GLY GLY H . n 
D 4 43  LYS 43  43  43  LYS LYS H . n 
D 4 44  GLY 44  44  44  GLY GLY H . n 
D 4 45  LEU 45  45  45  LEU LEU H . n 
D 4 46  GLU 46  46  46  GLU GLU H . n 
D 4 47  TRP 47  47  47  TRP TRP H . n 
D 4 48  MET 48  48  48  MET MET H . n 
D 4 49  GLY 49  49  49  GLY GLY H . n 
D 4 50  ILE 50  50  50  ILE ILE H . n 
D 4 51  ILE 51  51  51  ILE ILE H . n 
D 4 52  TYR 52  52  52  TYR TYR H . n 
D 4 53  PRO 53  52  52  PRO PRO H A n 
D 4 54  ALA 54  53  53  ALA ALA H . n 
D 4 55  ASP 55  54  54  ASP ASP H . n 
D 4 56  SER 56  55  55  SER SER H . n 
D 4 57  GLU 57  56  56  GLU GLU H . n 
D 4 58  THR 58  57  57  THR THR H . n 
D 4 59  ARG 59  58  58  ARG ARG H . n 
D 4 60  TYR 60  59  59  TYR TYR H . n 
D 4 61  SER 61  60  60  SER SER H . n 
D 4 62  PRO 62  61  61  PRO PRO H . n 
D 4 63  SER 63  62  62  SER SER H . n 
D 4 64  PHE 64  63  63  PHE PHE H . n 
D 4 65  GLN 65  64  64  GLN GLN H . n 
D 4 66  GLY 66  65  65  GLY GLY H . n 
D 4 67  GLN 67  66  66  GLN GLN H . n 
D 4 68  VAL 68  67  67  VAL VAL H . n 
D 4 69  THR 69  68  68  THR THR H . n 
D 4 70  ILE 70  69  69  ILE ILE H . n 
D 4 71  SER 71  70  70  SER SER H . n 
D 4 72  ALA 72  71  71  ALA ALA H . n 
D 4 73  ASP 73  72  72  ASP ASP H . n 
D 4 74  LYS 74  73  73  LYS LYS H . n 
D 4 75  SER 75  74  74  SER SER H . n 
D 4 76  ILE 76  75  75  ILE ILE H . n 
D 4 77  ASN 77  76  76  ASN ASN H . n 
D 4 78  THR 78  77  77  THR THR H . n 
D 4 79  ALA 79  78  78  ALA ALA H . n 
D 4 80  TYR 80  79  79  TYR TYR H . n 
D 4 81  LEU 81  80  80  LEU LEU H . n 
D 4 82  GLN 82  81  81  GLN GLN H . n 
D 4 83  TRP 83  82  82  TRP TRP H . n 
D 4 84  SER 84  82  82  SER SER H A n 
D 4 85  SER 85  82  82  SER SER H B n 
D 4 86  LEU 86  82  82  LEU LEU H C n 
D 4 87  LYS 87  83  83  LYS LYS H . n 
D 4 88  ALA 88  84  84  ALA ALA H . n 
D 4 89  SER 89  85  85  SER SER H . n 
D 4 90  ASP 90  86  86  ASP ASP H . n 
D 4 91  THR 91  87  87  THR THR H . n 
D 4 92  ALA 92  88  88  ALA ALA H . n 
D 4 93  ILE 93  89  89  ILE ILE H . n 
D 4 94  TYR 94  90  90  TYR TYR H . n 
D 4 95  TYR 95  91  91  TYR TYR H . n 
D 4 96  CYS 96  92  92  CYS CYS H . n 
D 4 97  ALA 97  93  93  ALA ALA H . n 
D 4 98  GLY 98  94  94  GLY GLY H . n 
D 4 99  GLY 99  95  95  GLY GLY H . n 
D 4 100 SER 100 96  96  SER SER H . n 
D 4 101 GLY 101 97  97  GLY GLY H . n 
D 4 102 ILE 102 98  98  ILE ILE H . n 
D 4 103 PHE 103 99  99  PHE PHE H . n 
D 4 104 THR 104 100 100 THR THR H . n 
D 4 105 PRO 105 100 100 PRO PRO H A n 
D 4 106 MET 106 100 100 MET MET H B n 
D 4 107 ASP 107 101 101 ASP ASP H . n 
D 4 108 VAL 108 102 102 VAL VAL H . n 
D 4 109 TRP 109 103 103 TRP TRP H . n 
D 4 110 GLY 110 104 104 GLY GLY H . n 
D 4 111 GLN 111 105 105 GLN GLN H . n 
D 4 112 GLY 112 106 106 GLY GLY H . n 
D 4 113 THR 113 107 107 THR THR H . n 
D 4 114 THR 114 108 108 THR THR H . n 
D 4 115 VAL 115 109 109 VAL VAL H . n 
D 4 116 THR 116 110 110 THR THR H . n 
D 4 117 VAL 117 111 111 VAL VAL H . n 
D 4 118 SER 118 112 112 SER SER H . n 
D 4 119 SER 119 113 113 SER SER H . n 
D 4 120 ALA 120 114 114 ALA ALA H . n 
D 4 121 SER 121 115 115 SER SER H . n 
D 4 122 THR 122 116 116 THR THR H . n 
D 4 123 LYS 123 117 117 LYS LYS H . n 
D 4 124 GLY 124 118 118 GLY GLY H . n 
D 4 125 PRO 125 119 119 PRO PRO H . n 
D 4 126 SER 126 120 120 SER SER H . n 
D 4 127 VAL 127 121 121 VAL VAL H . n 
D 4 128 PHE 128 122 122 PHE PHE H . n 
D 4 129 PRO 129 123 123 PRO PRO H . n 
D 4 130 LEU 130 124 124 LEU LEU H . n 
D 4 131 ALA 131 125 125 ALA ALA H . n 
D 4 132 PRO 132 126 126 PRO PRO H . n 
D 4 133 SER 133 127 127 SER SER H . n 
D 4 134 SER 134 128 128 SER SER H . n 
D 4 135 LYS 135 129 129 LYS LYS H . n 
D 4 136 SER 136 130 130 SER SER H . n 
D 4 137 THR 137 131 131 THR THR H . n 
D 4 138 SER 138 132 132 SER SER H . n 
D 4 139 GLY 139 133 133 GLY GLY H . n 
D 4 140 GLY 140 134 134 GLY GLY H . n 
D 4 141 THR 141 135 135 THR THR H . n 
D 4 142 ALA 142 136 136 ALA ALA H . n 
D 4 143 ALA 143 137 137 ALA ALA H . n 
D 4 144 LEU 144 138 138 LEU LEU H . n 
D 4 145 GLY 145 139 139 GLY GLY H . n 
D 4 146 CYS 146 140 140 CYS CYS H . n 
D 4 147 LEU 147 141 141 LEU LEU H . n 
D 4 148 VAL 148 142 142 VAL VAL H . n 
D 4 149 LYS 149 143 143 LYS LYS H . n 
D 4 150 ASP 150 144 144 ASP ASP H . n 
D 4 151 TYR 151 145 145 TYR TYR H . n 
D 4 152 PHE 152 146 146 PHE PHE H . n 
D 4 153 PRO 153 147 147 PRO PRO H . n 
D 4 154 GLU 154 148 148 GLU GLU H . n 
D 4 155 PRO 155 149 149 PRO PRO H . n 
D 4 156 VAL 156 150 150 VAL VAL H . n 
D 4 157 THR 157 151 151 THR THR H . n 
D 4 158 VAL 158 152 152 VAL VAL H . n 
D 4 159 SER 159 153 153 SER SER H . n 
D 4 160 TRP 160 154 154 TRP TRP H . n 
D 4 161 ASN 161 155 155 ASN ASN H . n 
D 4 162 SER 162 156 156 SER SER H . n 
D 4 163 GLY 163 157 157 GLY GLY H . n 
D 4 164 ALA 164 158 158 ALA ALA H . n 
D 4 165 LEU 165 159 159 LEU LEU H . n 
D 4 166 THR 166 160 160 THR THR H . n 
D 4 167 SER 167 161 161 SER SER H . n 
D 4 168 GLY 168 162 162 GLY GLY H . n 
D 4 169 VAL 169 163 163 VAL VAL H . n 
D 4 170 HIS 170 164 164 HIS HIS H . n 
D 4 171 THR 171 165 165 THR THR H . n 
D 4 172 PHE 172 166 166 PHE PHE H . n 
D 4 173 PRO 173 167 167 PRO PRO H . n 
D 4 174 ALA 174 168 168 ALA ALA H . n 
D 4 175 VAL 175 169 169 VAL VAL H . n 
D 4 176 LEU 176 170 170 LEU LEU H . n 
D 4 177 GLN 177 171 171 GLN GLN H . n 
D 4 178 SER 178 172 172 SER SER H . n 
D 4 179 SER 179 173 173 SER SER H . n 
D 4 180 GLY 180 174 174 GLY GLY H . n 
D 4 181 LEU 181 175 175 LEU LEU H . n 
D 4 182 TYR 182 176 176 TYR TYR H . n 
D 4 183 SER 183 177 177 SER SER H . n 
D 4 184 LEU 184 178 178 LEU LEU H . n 
D 4 185 SER 185 179 179 SER SER H . n 
D 4 186 SER 186 180 180 SER SER H . n 
D 4 187 VAL 187 181 181 VAL VAL H . n 
D 4 188 VAL 188 182 182 VAL VAL H . n 
D 4 189 THR 189 183 183 THR THR H . n 
D 4 190 VAL 190 184 184 VAL VAL H . n 
D 4 191 PRO 191 185 185 PRO PRO H . n 
D 4 192 SER 192 186 186 SER SER H . n 
D 4 193 SER 193 187 187 SER SER H . n 
D 4 194 SER 194 188 188 SER SER H . n 
D 4 195 LEU 195 189 189 LEU LEU H . n 
D 4 196 GLY 196 190 190 GLY GLY H . n 
D 4 197 THR 197 191 191 THR THR H . n 
D 4 198 GLN 198 192 192 GLN GLN H . n 
D 4 199 THR 199 193 193 THR THR H . n 
D 4 200 TYR 200 194 194 TYR TYR H . n 
D 4 201 ILE 201 195 195 ILE ILE H . n 
D 4 202 CYS 202 196 196 CYS CYS H . n 
D 4 203 ASN 203 197 197 ASN ASN H . n 
D 4 204 VAL 204 198 198 VAL VAL H . n 
D 4 205 ASN 205 199 199 ASN ASN H . n 
D 4 206 HIS 206 200 200 HIS HIS H . n 
D 4 207 LYS 207 201 201 LYS LYS H . n 
D 4 208 PRO 208 202 202 PRO PRO H . n 
D 4 209 SER 209 203 203 SER SER H . n 
D 4 210 ASN 210 204 204 ASN ASN H . n 
D 4 211 THR 211 205 205 THR THR H . n 
D 4 212 LYS 212 206 206 LYS LYS H . n 
D 4 213 VAL 213 207 207 VAL VAL H . n 
D 4 214 ASP 214 208 208 ASP ASP H . n 
D 4 215 LYS 215 209 209 LYS LYS H . n 
D 4 216 LYS 216 210 210 LYS LYS H . n 
D 4 217 VAL 217 211 211 VAL VAL H . n 
D 4 218 GLU 218 212 212 GLU GLU H . n 
D 4 219 PRO 219 213 213 PRO PRO H . n 
D 4 220 LYS 220 214 214 LYS LYS H . n 
D 4 221 SER 221 215 ?   ?   ?   H . n 
D 4 222 CYS 222 216 ?   ?   ?   H . n 
E 5 1   ASP 1   1   1   ASP ASP L . n 
E 5 2   ILE 2   2   2   ILE ILE L . n 
E 5 3   GLN 3   3   3   GLN GLN L . n 
E 5 4   LEU 4   4   4   LEU LEU L . n 
E 5 5   THR 5   5   5   THR THR L . n 
E 5 6   GLN 6   6   6   GLN GLN L . n 
E 5 7   SER 7   7   7   SER SER L . n 
E 5 8   PRO 8   8   8   PRO PRO L . n 
E 5 9   ASP 9   9   9   ASP ASP L . n 
E 5 10  SER 10  10  10  SER SER L . n 
E 5 11  LEU 11  11  11  LEU LEU L . n 
E 5 12  ALA 12  12  12  ALA ALA L . n 
E 5 13  VAL 13  13  13  VAL VAL L . n 
E 5 14  SER 14  14  14  SER SER L . n 
E 5 15  LEU 15  15  15  LEU LEU L . n 
E 5 16  GLY 16  16  16  GLY GLY L . n 
E 5 17  GLU 17  17  17  GLU GLU L . n 
E 5 18  ARG 18  18  18  ARG ARG L . n 
E 5 19  ALA 19  19  19  ALA ALA L . n 
E 5 20  THR 20  20  20  THR THR L . n 
E 5 21  ILE 21  21  21  ILE ILE L . n 
E 5 22  ASN 22  22  22  ASN ASN L . n 
E 5 23  CYS 23  23  23  CYS CYS L . n 
E 5 24  LYS 24  24  24  LYS LYS L . n 
E 5 25  SER 25  25  25  SER SER L . n 
E 5 26  SER 26  26  26  SER SER L . n 
E 5 27  GLN 27  27  27  GLN GLN L . n 
E 5 28  SER 28  27  27  SER SER L A n 
E 5 29  VAL 29  27  27  VAL VAL L B n 
E 5 30  LEU 30  27  27  LEU LEU L C n 
E 5 31  TYR 31  27  27  TYR TYR L D n 
E 5 32  SER 32  27  27  SER SER L E n 
E 5 33  SER 33  27  27  SER SER L F n 
E 5 34  ILE 34  28  28  ILE ILE L . n 
E 5 35  ASN 35  29  29  ASN ASN L . n 
E 5 36  LYS 36  30  30  LYS LYS L . n 
E 5 37  ASN 37  31  31  ASN ASN L . n 
E 5 38  TYR 38  32  32  TYR TYR L . n 
E 5 39  LEU 39  33  33  LEU LEU L . n 
E 5 40  ALA 40  34  34  ALA ALA L . n 
E 5 41  TRP 41  35  35  TRP TRP L . n 
E 5 42  TYR 42  36  36  TYR TYR L . n 
E 5 43  GLN 43  37  37  GLN GLN L . n 
E 5 44  GLN 44  38  38  GLN GLN L . n 
E 5 45  LYS 45  39  39  LYS LYS L . n 
E 5 46  PRO 46  40  40  PRO PRO L . n 
E 5 47  GLY 47  41  41  GLY GLY L . n 
E 5 48  GLN 48  42  42  GLN GLN L . n 
E 5 49  PRO 49  43  43  PRO PRO L . n 
E 5 50  PRO 50  44  44  PRO PRO L . n 
E 5 51  LYS 51  45  45  LYS LYS L . n 
E 5 52  LEU 52  46  46  LEU LEU L . n 
E 5 53  LEU 53  47  47  LEU LEU L . n 
E 5 54  ILE 54  48  48  ILE ILE L . n 
E 5 55  TYR 55  49  49  TYR TYR L . n 
E 5 56  TRP 56  50  50  TRP TRP L . n 
E 5 57  ALA 57  51  51  ALA ALA L . n 
E 5 58  SER 58  52  52  SER SER L . n 
E 5 59  THR 59  53  53  THR THR L . n 
E 5 60  ARG 60  54  54  ARG ARG L . n 
E 5 61  GLU 61  55  55  GLU GLU L . n 
E 5 62  SER 62  56  56  SER SER L . n 
E 5 63  GLY 63  57  57  GLY GLY L . n 
E 5 64  VAL 64  58  58  VAL VAL L . n 
E 5 65  PRO 65  59  59  PRO PRO L . n 
E 5 66  ASP 66  60  60  ASP ASP L . n 
E 5 67  ARG 67  61  61  ARG ARG L . n 
E 5 68  PHE 68  62  62  PHE PHE L . n 
E 5 69  SER 69  63  63  SER SER L . n 
E 5 70  GLY 70  64  64  GLY GLY L . n 
E 5 71  SER 71  65  65  SER SER L . n 
E 5 72  GLY 72  66  66  GLY GLY L . n 
E 5 73  SER 73  67  67  SER SER L . n 
E 5 74  GLY 74  68  68  GLY GLY L . n 
E 5 75  THR 75  69  69  THR THR L . n 
E 5 76  ASP 76  70  70  ASP ASP L . n 
E 5 77  PHE 77  71  71  PHE PHE L . n 
E 5 78  THR 78  72  72  THR THR L . n 
E 5 79  LEU 79  73  73  LEU LEU L . n 
E 5 80  THR 80  74  74  THR THR L . n 
E 5 81  ILE 81  75  75  ILE ILE L . n 
E 5 82  SER 82  76  76  SER SER L . n 
E 5 83  SER 83  77  77  SER SER L . n 
E 5 84  LEU 84  78  78  LEU LEU L . n 
E 5 85  GLN 85  79  79  GLN GLN L . n 
E 5 86  ALA 86  80  80  ALA ALA L . n 
E 5 87  GLU 87  81  81  GLU GLU L . n 
E 5 88  ASP 88  82  82  ASP ASP L . n 
E 5 89  VAL 89  83  83  VAL VAL L . n 
E 5 90  ALA 90  84  84  ALA ALA L . n 
E 5 91  VAL 91  85  85  VAL VAL L . n 
E 5 92  TYR 92  86  86  TYR TYR L . n 
E 5 93  TYR 93  87  87  TYR TYR L . n 
E 5 94  CYS 94  88  88  CYS CYS L . n 
E 5 95  GLN 95  89  89  GLN GLN L . n 
E 5 96  GLN 96  90  90  GLN GLN L . n 
E 5 97  TYR 97  91  91  TYR TYR L . n 
E 5 98  TYR 98  92  92  TYR TYR L . n 
E 5 99  SER 99  93  93  SER SER L . n 
E 5 100 THR 100 94  94  THR THR L . n 
E 5 101 PRO 101 95  95  PRO PRO L . n 
E 5 102 TYR 102 96  96  TYR TYR L . n 
E 5 103 THR 103 97  97  THR THR L . n 
E 5 104 PHE 104 98  98  PHE PHE L . n 
E 5 105 GLY 105 99  99  GLY GLY L . n 
E 5 106 GLN 106 100 100 GLN GLN L . n 
E 5 107 GLY 107 101 101 GLY GLY L . n 
E 5 108 THR 108 102 102 THR THR L . n 
E 5 109 LYS 109 103 103 LYS LYS L . n 
E 5 110 VAL 110 104 104 VAL VAL L . n 
E 5 111 GLU 111 105 105 GLU GLU L . n 
E 5 112 ILE 112 106 106 ILE ILE L . n 
E 5 113 LYS 113 107 107 LYS LYS L . n 
E 5 114 ARG 114 108 108 ARG ARG L . n 
E 5 115 THR 115 109 109 THR THR L . n 
E 5 116 VAL 116 110 110 VAL VAL L . n 
E 5 117 ALA 117 111 111 ALA ALA L . n 
E 5 118 ALA 118 112 112 ALA ALA L . n 
E 5 119 PRO 119 113 113 PRO PRO L . n 
E 5 120 SER 120 114 114 SER SER L . n 
E 5 121 VAL 121 115 115 VAL VAL L . n 
E 5 122 PHE 122 116 116 PHE PHE L . n 
E 5 123 ILE 123 117 117 ILE ILE L . n 
E 5 124 PHE 124 118 118 PHE PHE L . n 
E 5 125 PRO 125 119 119 PRO PRO L . n 
E 5 126 PRO 126 120 120 PRO PRO L . n 
E 5 127 SER 127 121 121 SER SER L . n 
E 5 128 ASP 128 122 122 ASP ASP L . n 
E 5 129 GLU 129 123 123 GLU GLU L . n 
E 5 130 GLN 130 124 124 GLN GLN L . n 
E 5 131 LEU 131 125 125 LEU LEU L . n 
E 5 132 LYS 132 126 126 LYS LYS L . n 
E 5 133 SER 133 127 127 SER SER L . n 
E 5 134 GLY 134 128 128 GLY GLY L . n 
E 5 135 THR 135 129 129 THR THR L . n 
E 5 136 ALA 136 130 130 ALA ALA L . n 
E 5 137 SER 137 131 131 SER SER L . n 
E 5 138 VAL 138 132 132 VAL VAL L . n 
E 5 139 VAL 139 133 133 VAL VAL L . n 
E 5 140 CYS 140 134 134 CYS CYS L . n 
E 5 141 LEU 141 135 135 LEU LEU L . n 
E 5 142 LEU 142 136 136 LEU LEU L . n 
E 5 143 ASN 143 137 137 ASN ASN L . n 
E 5 144 ASN 144 138 138 ASN ASN L . n 
E 5 145 PHE 145 139 139 PHE PHE L . n 
E 5 146 TYR 146 140 140 TYR TYR L . n 
E 5 147 PRO 147 141 141 PRO PRO L . n 
E 5 148 ARG 148 142 142 ARG ARG L . n 
E 5 149 GLU 149 143 143 GLU GLU L . n 
E 5 150 ALA 150 144 144 ALA ALA L . n 
E 5 151 LYS 151 145 145 LYS LYS L . n 
E 5 152 VAL 152 146 146 VAL VAL L . n 
E 5 153 GLN 153 147 147 GLN GLN L . n 
E 5 154 TRP 154 148 148 TRP TRP L . n 
E 5 155 LYS 155 149 149 LYS LYS L . n 
E 5 156 VAL 156 150 150 VAL VAL L . n 
E 5 157 ASP 157 151 151 ASP ASP L . n 
E 5 158 ASN 158 152 152 ASN ASN L . n 
E 5 159 ALA 159 153 153 ALA ALA L . n 
E 5 160 LEU 160 154 154 LEU LEU L . n 
E 5 161 GLN 161 155 155 GLN GLN L . n 
E 5 162 SER 162 156 156 SER SER L . n 
E 5 163 GLY 163 157 157 GLY GLY L . n 
E 5 164 ASN 164 158 158 ASN ASN L . n 
E 5 165 SER 165 159 159 SER SER L . n 
E 5 166 GLN 166 160 160 GLN GLN L . n 
E 5 167 GLU 167 161 161 GLU GLU L . n 
E 5 168 SER 168 162 162 SER SER L . n 
E 5 169 VAL 169 163 163 VAL VAL L . n 
E 5 170 THR 170 164 164 THR THR L . n 
E 5 171 GLU 171 165 165 GLU GLU L . n 
E 5 172 GLN 172 166 166 GLN GLN L . n 
E 5 173 ASP 173 167 167 ASP ASP L . n 
E 5 174 SER 174 168 168 SER SER L . n 
E 5 175 LYS 175 169 169 LYS LYS L . n 
E 5 176 ASP 176 170 170 ASP ASP L . n 
E 5 177 SER 177 171 171 SER SER L . n 
E 5 178 THR 178 172 172 THR THR L . n 
E 5 179 TYR 179 173 173 TYR TYR L . n 
E 5 180 SER 180 174 174 SER SER L . n 
E 5 181 LEU 181 175 175 LEU LEU L . n 
E 5 182 SER 182 176 176 SER SER L . n 
E 5 183 SER 183 177 177 SER SER L . n 
E 5 184 THR 184 178 178 THR THR L . n 
E 5 185 LEU 185 179 179 LEU LEU L . n 
E 5 186 THR 186 180 180 THR THR L . n 
E 5 187 LEU 187 181 181 LEU LEU L . n 
E 5 188 SER 188 182 182 SER SER L . n 
E 5 189 LYS 189 183 183 LYS LYS L . n 
E 5 190 ALA 190 184 184 ALA ALA L . n 
E 5 191 ASP 191 185 185 ASP ASP L . n 
E 5 192 TYR 192 186 186 TYR TYR L . n 
E 5 193 GLU 193 187 187 GLU GLU L . n 
E 5 194 LYS 194 188 188 LYS LYS L . n 
E 5 195 HIS 195 189 189 HIS HIS L . n 
E 5 196 LYS 196 190 190 LYS LYS L . n 
E 5 197 VAL 197 191 191 VAL VAL L . n 
E 5 198 TYR 198 192 192 TYR TYR L . n 
E 5 199 ALA 199 193 193 ALA ALA L . n 
E 5 200 CYS 200 194 194 CYS CYS L . n 
E 5 201 GLU 201 195 195 GLU GLU L . n 
E 5 202 VAL 202 196 196 VAL VAL L . n 
E 5 203 THR 203 197 197 THR THR L . n 
E 5 204 HIS 204 198 198 HIS HIS L . n 
E 5 205 GLN 205 199 199 GLN GLN L . n 
E 5 206 GLY 206 200 200 GLY GLY L . n 
E 5 207 LEU 207 201 201 LEU LEU L . n 
E 5 208 SER 208 202 202 SER SER L . n 
E 5 209 SER 209 203 203 SER SER L . n 
E 5 210 PRO 210 204 204 PRO PRO L . n 
E 5 211 VAL 211 205 205 VAL VAL L . n 
E 5 212 THR 212 206 206 THR THR L . n 
E 5 213 LYS 213 207 207 LYS LYS L . n 
E 5 214 SER 214 208 208 SER SER L . n 
E 5 215 PHE 215 209 209 PHE PHE L . n 
E 5 216 ASN 216 210 210 ASN ASN L . n 
E 5 217 ARG 217 211 211 ARG ARG L . n 
E 5 218 GLY 218 212 ?   ?   ?   L . n 
E 5 219 GLU 219 213 ?   ?   ?   L . n 
E 5 220 CYS 220 214 ?   ?   ?   L . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
F 6 NAG 1 B NAG 1 B NAG 1 n 
F 6 NAG 2 B NAG 2 B NAG 2 n 
F 6 BMA 3 B BMA 3 B BMA 3 n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
G 7 CIT 1 601 532 CIT CIT A . 
H 7 CIT 1 602 533 CIT CIT A . 
I 7 CIT 1 603 301 CIT CIT A . 
J 8 HOH 1 701 4   HOH HOH A . 
K 8 HOH 1 301 3   HOH HOH G . 
K 8 HOH 2 302 7   HOH HOH G . 
L 8 HOH 1 301 9   HOH HOH H . 
L 8 HOH 2 302 8   HOH HOH H . 
M 8 HOH 1 301 6   HOH HOH L . 
M 8 HOH 2 302 5   HOH HOH L . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? '(1.21rc1_5127: ???)' 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .                     2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .                     3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER   ? ? ? .                     4 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9CPQ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     109.917 
_cell.length_a_esd                 ? 
_cell.length_b                     109.917 
_cell.length_b_esd                 ? 
_cell.length_c                     225.187 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9CPQ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                92 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 41 21 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9CPQ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.89 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          57.47 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
'0.1 M sodium citrate citric acid buffer (pH 3.83), 25% (v/v) polyethylene glycol 200, and 9% (w/v) polyethylene glycol 6000' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293.15 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2023-12-01 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97946 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRL BEAMLINE BL12-1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97946 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL12-1 
_diffrn_source.pdbx_synchrotron_site       SSRL 
# 
_reflns.B_iso_Wilson_estimate                          ? 
_reflns.entry_id                                       9CPQ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.88 
_reflns.d_resolution_low                               50.00 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     32161 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100.0 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                24.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          4.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               0.970 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.292 
_reflns.pdbx_Rpim_I_all                                0.058 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       795973 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.286 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
loop_
_reflns_shell.d_res_high 
_reflns_shell.d_res_low 
_reflns_shell.meanI_over_sigI_all 
_reflns_shell.meanI_over_sigI_obs 
_reflns_shell.number_measured_all 
_reflns_shell.number_measured_obs 
_reflns_shell.number_possible 
_reflns_shell.number_unique_all 
_reflns_shell.number_unique_obs 
_reflns_shell.percent_possible_obs 
_reflns_shell.Rmerge_F_all 
_reflns_shell.Rmerge_F_obs 
_reflns_shell.meanI_over_sigI_gt 
_reflns_shell.meanI_over_uI_all 
_reflns_shell.meanI_over_uI_gt 
_reflns_shell.number_measured_gt 
_reflns_shell.number_unique_gt 
_reflns_shell.percent_possible_gt 
_reflns_shell.Rmerge_F_gt 
_reflns_shell.Rmerge_I_gt 
_reflns_shell.pdbx_redundancy 
_reflns_shell.pdbx_chi_squared 
_reflns_shell.pdbx_netI_over_sigmaI_all 
_reflns_shell.pdbx_netI_over_sigmaI_obs 
_reflns_shell.pdbx_Rrim_I_all 
_reflns_shell.pdbx_Rpim_I_all 
_reflns_shell.pdbx_rejects 
_reflns_shell.pdbx_ordinal 
_reflns_shell.pdbx_diffrn_id 
_reflns_shell.pdbx_CC_half 
_reflns_shell.pdbx_CC_star 
_reflns_shell.pdbx_R_split 
_reflns_shell.percent_possible_all 
_reflns_shell.Rmerge_I_all 
_reflns_shell.Rmerge_I_obs 
_reflns_shell.pdbx_Rsym_value 
_reflns_shell.pdbx_percent_possible_ellipsoidal 
_reflns_shell.pdbx_percent_possible_spherical 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous 
_reflns_shell.pdbx_percent_possible_spherical_anomalous 
_reflns_shell.pdbx_redundancy_anomalous 
_reflns_shell.pdbx_CC_half_anomalous 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous 
_reflns_shell.pdbx_percent_possible_anomalous 
2.88 2.93  ? ? ? ? ? ? 1543 ? ? ? ? ? ? ? ? ? ? ? 15.9 0.849 ? ? 2.971 0.696 ? 1  1 0.462 0.795 ? 99.5  ? 2.884 ? ? ? ? ? ? ? ? ? 
2.93 2.98  ? ? ? ? ? ? 1587 ? ? ? ? ? ? ? ? ? ? ? 20.9 0.858 ? ? 2.762 0.576 ? 2  1 0.577 0.855 ? 99.9  ? 2.699 ? ? ? ? ? ? ? ? ? 
2.98 3.04  ? ? ? ? ? ? 1566 ? ? ? ? ? ? ? ? ? ? ? 22.9 0.880 ? ? 2.467 0.498 ? 3  1 0.652 0.889 ? 100.0 ? 2.415 ? ? ? ? ? ? ? ? ? 
3.04 3.10  ? ? ? ? ? ? 1574 ? ? ? ? ? ? ? ? ? ? ? 24.3 0.891 ? ? 2.091 0.413 ? 4  1 0.750 0.926 ? 100.0 ? 2.049 ? ? ? ? ? ? ? ? ? 
3.10 3.17  ? ? ? ? ? ? 1584 ? ? ? ? ? ? ? ? ? ? ? 25.8 0.903 ? ? 1.700 0.329 ? 5  1 0.856 0.960 ? 100.0 ? 1.668 ? ? ? ? ? ? ? ? ? 
3.17 3.24  ? ? ? ? ? ? 1583 ? ? ? ? ? ? ? ? ? ? ? 25.9 0.928 ? ? 1.403 0.272 ? 6  1 0.872 0.965 ? 100.0 ? 1.376 ? ? ? ? ? ? ? ? ? 
3.24 3.32  ? ? ? ? ? ? 1570 ? ? ? ? ? ? ? ? ? ? ? 26.4 0.935 ? ? 1.159 0.223 ? 7  1 0.893 0.971 ? 100.0 ? 1.137 ? ? ? ? ? ? ? ? ? 
3.32 3.41  ? ? ? ? ? ? 1589 ? ? ? ? ? ? ? ? ? ? ? 26.4 0.978 ? ? 0.912 0.176 ? 8  1 0.941 0.985 ? 100.0 ? 0.895 ? ? ? ? ? ? ? ? ? 
3.41 3.51  ? ? ? ? ? ? 1584 ? ? ? ? ? ? ? ? ? ? ? 26.4 1.031 ? ? 0.706 0.137 ? 9  1 0.962 0.990 ? 100.0 ? 0.693 ? ? ? ? ? ? ? ? ? 
3.51 3.63  ? ? ? ? ? ? 1590 ? ? ? ? ? ? ? ? ? ? ? 26.2 1.010 ? ? 0.547 0.106 ? 10 1 0.978 0.994 ? 99.9  ? 0.537 ? ? ? ? ? ? ? ? ? 
3.63 3.76  ? ? ? ? ? ? 1581 ? ? ? ? ? ? ? ? ? ? ? 25.8 1.037 ? ? 0.457 0.089 ? 11 1 0.981 0.995 ? 100.0 ? 0.448 ? ? ? ? ? ? ? ? ? 
3.76 3.91  ? ? ? ? ? ? 1612 ? ? ? ? ? ? ? ? ? ? ? 25.3 1.063 ? ? 0.371 0.073 ? 12 1 0.988 0.997 ? 100.0 ? 0.363 ? ? ? ? ? ? ? ? ? 
3.91 4.09  ? ? ? ? ? ? 1608 ? ? ? ? ? ? ? ? ? ? ? 24.3 1.080 ? ? 0.284 0.057 ? 13 1 0.991 0.998 ? 100.0 ? 0.278 ? ? ? ? ? ? ? ? ? 
4.09 4.30  ? ? ? ? ? ? 1584 ? ? ? ? ? ? ? ? ? ? ? 21.6 1.116 ? ? 0.210 0.045 ? 14 1 0.993 0.998 ? 100.0 ? 0.205 ? ? ? ? ? ? ? ? ? 
4.30 4.57  ? ? ? ? ? ? 1629 ? ? ? ? ? ? ? ? ? ? ? 27.3 1.116 ? ? 0.156 0.030 ? 15 1 0.996 0.999 ? 100.0 ? 0.154 ? ? ? ? ? ? ? ? ? 
4.57 4.92  ? ? ? ? ? ? 1610 ? ? ? ? ? ? ? ? ? ? ? 27.8 1.112 ? ? 0.139 0.026 ? 16 1 0.997 0.999 ? 100.0 ? 0.137 ? ? ? ? ? ? ? ? ? 
4.92 5.42  ? ? ? ? ? ? 1622 ? ? ? ? ? ? ? ? ? ? ? 27.4 1.053 ? ? 0.127 0.024 ? 17 1 0.997 0.999 ? 99.9  ? 0.125 ? ? ? ? ? ? ? ? ? 
5.42 6.20  ? ? ? ? ? ? 1654 ? ? ? ? ? ? ? ? ? ? ? 26.7 0.967 ? ? 0.125 0.024 ? 18 1 0.997 0.999 ? 99.9  ? 0.122 ? ? ? ? ? ? ? ? ? 
6.20 7.81  ? ? ? ? ? ? 1685 ? ? ? ? ? ? ? ? ? ? ? 24.5 0.857 ? ? 0.096 0.019 ? 19 1 0.998 0.999 ? 100.0 ? 0.094 ? ? ? ? ? ? ? ? ? 
7.81 50.00 ? ? ? ? ? ? 1806 ? ? ? ? ? ? ? ? ? ? ? 23.1 0.644 ? ? 0.049 0.010 ? 20 1 0.998 1.000 ? 99.9  ? 0.048 ? ? ? ? ? ? ? ? ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9CPQ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.88 
_refine.ls_d_res_low                             49.39 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     30524 
_refine.ls_number_reflns_R_free                  2000 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    95.11 
_refine.ls_percent_reflns_R_free                 6.55 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2048 
_refine.ls_R_factor_R_free                       0.2506 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2015 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ML 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.10 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.90 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 25.48 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.37 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.88 
_refine_hist.d_res_low                        49.39 
_refine_hist.number_atoms_solvent             7 
_refine_hist.number_atoms_total               8196 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        8111 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         78 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.003  ? ?    ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.525  ? ?    ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 14.873 ? 2985 ? f_dihedral_angle_d ? ? 
'X-RAY DIFFRACTION' ? 0.043  ? 1269 ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.004  ? 1458 ? f_plane_restr      ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.88 2.95  . . 94  1340 65.00  . . . . 0.3125 . . . . . . . . . . . 0.3856 
'X-RAY DIFFRACTION' 2.95 3.03  . . 120 1701 81.00  . . . . 0.3067 . . . . . . . . . . . 0.3828 
'X-RAY DIFFRACTION' 3.03 3.12  . . 132 1897 90.00  . . . . 0.3018 . . . . . . . . . . . 0.3469 
'X-RAY DIFFRACTION' 3.12 3.22  . . 143 2035 96.00  . . . . 0.2779 . . . . . . . . . . . 0.3411 
'X-RAY DIFFRACTION' 3.22 3.34  . . 147 2091 99.00  . . . . 0.2608 . . . . . . . . . . . 0.3101 
'X-RAY DIFFRACTION' 3.34 3.47  . . 146 2103 100.00 . . . . 0.2486 . . . . . . . . . . . 0.2976 
'X-RAY DIFFRACTION' 3.47 3.63  . . 149 2105 100.00 . . . . 0.2212 . . . . . . . . . . . 0.3207 
'X-RAY DIFFRACTION' 3.63 3.82  . . 147 2116 100.00 . . . . 0.2063 . . . . . . . . . . . 0.2732 
'X-RAY DIFFRACTION' 3.82 4.06  . . 149 2120 100.00 . . . . 0.1881 . . . . . . . . . . . 0.2537 
'X-RAY DIFFRACTION' 4.06 4.37  . . 151 2144 100.00 . . . . 0.1705 . . . . . . . . . . . 0.1989 
'X-RAY DIFFRACTION' 4.37 4.81  . . 151 2149 100.00 . . . . 0.1531 . . . . . . . . . . . 0.2047 
'X-RAY DIFFRACTION' 4.81 5.50  . . 153 2182 100.00 . . . . 0.1583 . . . . . . . . . . . 0.2065 
'X-RAY DIFFRACTION' 5.50 6.93  . . 153 2197 100.00 . . . . 0.1939 . . . . . . . . . . . 0.2572 
'X-RAY DIFFRACTION' 6.93 49.39 . . 165 2344 100.00 . . . . 0.1744 . . . . . . . . . . . 0.1793 
# 
_struct.entry_id                     9CPQ 
_struct.title                        
'Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies M22-44 and CC12.3' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9CPQ 
_struct_keywords.text            
'COVID-19, SARS-CoV-2, Receptor binding domain, Antibody, IMMUNE SYSTEM, Viral Protein-IMMUNE SYSTEM complex' 
_struct_keywords.pdbx_keywords   'Viral Protein/IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 6 ? 
G N N 7 ? 
H N N 7 ? 
I N N 7 ? 
J N N 8 ? 
K N N 8 ? 
L N N 8 ? 
M N N 8 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP SPIKE_SARS2 P0DTC2 ? 1 
;TNLCPFGEVFNATRFASVYAWNRKRISNCVADYSVLYNSASFSTFKCYGVSPTKLNDLCFTNVYADSFVIRGDEVRQIAP
GQTGKIADYNYKLPDDFTGCVIAWNSNNLDSKVGGNYNYLYRLFRKSNLKPFERDISTEIYQAGSTPCNGVEGFNCYFPL
QSYGFQPTNGVGYQPYRVVVLSFELLHAPATVCGPKKS
;
333 
2 PDB 9CPQ        9CPQ   ? 2 ? 1   
3 PDB 9CPQ        9CPQ   ? 3 ? 1   
4 PDB 9CPQ        9CPQ   ? 4 ? 1   
5 PDB 9CPQ        9CPQ   ? 5 ? 1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9CPQ A 1 ? 198 ? P0DTC2 333 ? 530 ? 333 530 
2 2 9CPQ F 1 ? 220 ? 9CPQ   1   ? 216 ? 1   216 
3 3 9CPQ G 1 ? 214 ? 9CPQ   1   ? 214 ? 1   214 
4 4 9CPQ H 1 ? 222 ? 9CPQ   1   ? 216 ? 1   216 
5 5 9CPQ L 1 ? 220 ? 9CPQ   1   ? 214 ? 1   214 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9CPQ GLY A 199 ? UNP P0DTC2 ? ? 'expression tag' 531 1 
1 9CPQ HIS A 200 ? UNP P0DTC2 ? ? 'expression tag' 532 2 
1 9CPQ HIS A 201 ? UNP P0DTC2 ? ? 'expression tag' 533 3 
1 9CPQ HIS A 202 ? UNP P0DTC2 ? ? 'expression tag' 534 4 
1 9CPQ HIS A 203 ? UNP P0DTC2 ? ? 'expression tag' 535 5 
1 9CPQ HIS A 204 ? UNP P0DTC2 ? ? 'expression tag' 536 6 
1 9CPQ HIS A 205 ? UNP P0DTC2 ? ? 'expression tag' 537 7 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   pentameric 
_pdbx_struct_assembly.oligomeric_count     5 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 12140 ? 
1 MORE         -38   ? 
1 'SSA (A^2)'  45790 ? 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,B,C,F,G,H,I,J,K 
1 2 D,E,L,M           
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   none 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z  1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000 
2 'crystal symmetry operation' 7_555 y,x,-z 0.0000000000 1.0000000000 0.0000000000 0.0000000000 1.0000000000 0.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 PRO A 5   ? ASN A 11  ? PRO A 337 ASN A 343 1 ? 7 
HELX_P HELX_P2  AA2 SER A 17  ? TRP A 21  ? SER A 349 TRP A 353 5 ? 5 
HELX_P HELX_P3  AA3 TYR A 33  ? ASN A 38  ? TYR A 365 ASN A 370 1 ? 6 
HELX_P HELX_P4  AA4 SER A 51  ? ASP A 57  ? SER A 383 ASP A 389 5 ? 7 
HELX_P HELX_P5  AA5 GLU A 74  ? ILE A 78  ? GLU A 406 ILE A 410 5 ? 5 
HELX_P HELX_P6  AA6 GLY A 84  ? ASN A 90  ? GLY A 416 ASN A 422 1 ? 7 
HELX_P HELX_P7  AA7 SER A 106 ? SER A 111 ? SER A 438 SER A 443 1 ? 6 
HELX_P HELX_P8  AA8 GLY A 170 ? TYR A 173 ? GLY A 502 TYR A 505 5 ? 4 
HELX_P HELX_P9  AA9 ARG B 86  ? THR B 90  ? ARG F 83  THR F 87  5 ? 5 
HELX_P HELX_P10 AB1 SER B 131 ? LYS B 133 ? SER F 127 LYS F 129 5 ? 3 
HELX_P HELX_P11 AB2 SER B 191 ? LEU B 193 ? SER F 187 LEU F 189 5 ? 3 
HELX_P HELX_P12 AB3 SER C 121 ? SER C 127 ? SER G 121 SER G 127 1 ? 7 
HELX_P HELX_P13 AB4 LYS C 183 ? GLU C 187 ? LYS G 183 GLU G 187 1 ? 5 
HELX_P HELX_P14 AB5 GLY D 28  ? TYR D 32  ? GLY H 28  TYR H 32  5 ? 5 
HELX_P HELX_P15 AB6 PRO D 62  ? GLN D 65  ? PRO H 61  GLN H 64  5 ? 4 
HELX_P HELX_P16 AB7 LYS D 87  ? THR D 91  ? LYS H 83  THR H 87  5 ? 5 
HELX_P HELX_P17 AB8 SER D 133 ? LYS D 135 ? SER H 127 LYS H 129 5 ? 3 
HELX_P HELX_P18 AB9 SER D 193 ? LEU D 195 ? SER H 187 LEU H 189 5 ? 3 
HELX_P HELX_P19 AC1 GLN E 85  ? VAL E 89  ? GLN L 79  VAL L 83  5 ? 5 
HELX_P HELX_P20 AC2 SER E 127 ? SER E 133 ? SER L 121 SER L 127 1 ? 7 
HELX_P HELX_P21 AC3 LYS E 189 ? GLU E 193 ? LYS L 183 GLU L 187 1 ? 5 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ?    ? A CYS 4   SG  ? ? ? 1_555 A CYS 29  SG ? ? A CYS 336 A CYS 361 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf2  disulf ?    ? A CYS 47  SG  ? ? ? 1_555 A CYS 100 SG ? ? A CYS 379 A CYS 432 1_555 ? ? ? ? ? ? ? 2.039 ? ?               
disulf3  disulf ?    ? A CYS 59  SG  ? ? ? 1_555 A CYS 193 SG ? ? A CYS 391 A CYS 525 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf4  disulf ?    ? A CYS 148 SG  ? ? ? 1_555 A CYS 156 SG ? ? A CYS 480 A CYS 488 1_555 ? ? ? ? ? ? ? 2.039 ? ?               
disulf5  disulf ?    ? B CYS 22  SG  ? ? ? 1_555 B CYS 95  SG ? ? F CYS 22  F CYS 92  1_555 ? ? ? ? ? ? ? 2.029 ? ?               
disulf6  disulf ?    ? B CYS 144 SG  ? ? ? 1_555 B CYS 200 SG ? ? F CYS 140 F CYS 196 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf7  disulf ?    ? C CYS 23  SG  ? ? ? 1_555 C CYS 88  SG ? ? G CYS 23  G CYS 88  1_555 ? ? ? ? ? ? ? 2.039 ? ?               
disulf8  disulf ?    ? C CYS 134 SG  ? ? ? 1_555 C CYS 194 SG ? ? G CYS 134 G CYS 194 1_555 ? ? ? ? ? ? ? 2.029 ? ?               
disulf9  disulf ?    ? D CYS 22  SG  ? ? ? 1_555 D CYS 96  SG ? ? H CYS 22  H CYS 92  1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf10 disulf ?    ? D CYS 146 SG  ? ? ? 1_555 D CYS 202 SG ? ? H CYS 140 H CYS 196 1_555 ? ? ? ? ? ? ? 2.033 ? ?               
disulf11 disulf ?    ? E CYS 23  SG  ? ? ? 1_555 E CYS 94  SG ? ? L CYS 23  L CYS 88  1_555 ? ? ? ? ? ? ? 2.039 ? ?               
disulf12 disulf ?    ? E CYS 140 SG  ? ? ? 1_555 E CYS 200 SG ? ? L CYS 134 L CYS 194 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
covale1  covale one  ? A ASN 11  ND2 ? ? ? 1_555 F NAG .   C1 ? ? A ASN 343 B NAG 1   1_555 ? ? ? ? ? ? ? 1.446 ? N-Glycosylation 
covale2  covale both ? F NAG .   O4  ? ? ? 1_555 F NAG .   C1 ? ? B NAG 1   B NAG 2   1_555 ? ? ? ? ? ? ? 1.445 ? ?               
covale3  covale both ? F NAG .   O4  ? ? ? 1_555 F BMA .   C1 ? ? B NAG 2   B BMA 3   1_555 ? ? ? ? ? ? ? 1.446 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG F .   ? ASN A 11  ? NAG B 1   ? 1_555 ASN A 343 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  CYS A 4   ? CYS A 29  ? CYS A 336 ? 1_555 CYS A 361 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
3  CYS A 47  ? CYS A 100 ? CYS A 379 ? 1_555 CYS A 432 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
4  CYS A 59  ? CYS A 193 ? CYS A 391 ? 1_555 CYS A 525 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
5  CYS A 148 ? CYS A 156 ? CYS A 480 ? 1_555 CYS A 488 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
6  CYS B 22  ? CYS B 95  ? CYS F 22  ? 1_555 CYS F 92  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7  CYS B 144 ? CYS B 200 ? CYS F 140 ? 1_555 CYS F 196 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS C 23  ? CYS C 88  ? CYS G 23  ? 1_555 CYS G 88  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS C 134 ? CYS C 194 ? CYS G 134 ? 1_555 CYS G 194 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS D 22  ? CYS D 96  ? CYS H 22  ? 1_555 CYS H 92  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
11 CYS D 146 ? CYS D 202 ? CYS H 140 ? 1_555 CYS H 196 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
12 CYS E 23  ? CYS E 94  ? CYS L 23  ? 1_555 CYS L 88  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
13 CYS E 140 ? CYS E 200 ? CYS L 134 ? 1_555 CYS L 194 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1  PHE 150 B . ? PHE 146 F PRO 151 B ? PRO 147 F 1 -4.41 
2  GLU 152 B . ? GLU 148 F PRO 153 B ? PRO 149 F 1 1.95  
3  SER 7   C . ? SER 7   G PRO 8   C ? PRO 8   G 1 1.80  
4  SER 94  C . ? SER 94  G PRO 95  C ? PRO 95  G 1 -3.87 
5  TYR 140 C . ? TYR 140 G PRO 141 C ? PRO 141 G 1 3.09  
6  PHE 152 D . ? PHE 146 H PRO 153 D ? PRO 147 H 1 -3.35 
7  GLU 154 D . ? GLU 148 H PRO 155 D ? PRO 149 H 1 0.70  
8  SER 7   E . ? SER 7   L PRO 8   E ? PRO 8   L 1 -5.14 
9  THR 100 E . ? THR 94  L PRO 101 E ? PRO 95  L 1 -1.37 
10 TYR 146 E . ? TYR 140 L PRO 147 E ? PRO 141 L 1 1.26  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 3 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 4 ? 
AA6 ? 6 ? 
AA7 ? 4 ? 
AA8 ? 4 ? 
AA9 ? 4 ? 
AB1 ? 3 ? 
AB2 ? 4 ? 
AB3 ? 6 ? 
AB4 ? 4 ? 
AB5 ? 4 ? 
AB6 ? 4 ? 
AB7 ? 4 ? 
AB8 ? 6 ? 
AB9 ? 4 ? 
AC1 ? 4 ? 
AC2 ? 4 ? 
AC3 ? 3 ? 
AC4 ? 4 ? 
AC5 ? 6 ? 
AC6 ? 4 ? 
AC7 ? 2 ? 
AC8 ? 4 ? 
AC9 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? parallel      
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA6 4 5 ? anti-parallel 
AA6 5 6 ? anti-parallel 
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
AA9 3 4 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB2 2 3 ? anti-parallel 
AB2 3 4 ? anti-parallel 
AB3 1 2 ? parallel      
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB3 4 5 ? anti-parallel 
AB3 5 6 ? anti-parallel 
AB4 1 2 ? parallel      
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB5 1 2 ? anti-parallel 
AB5 2 3 ? anti-parallel 
AB5 3 4 ? anti-parallel 
AB6 1 2 ? anti-parallel 
AB6 2 3 ? anti-parallel 
AB6 3 4 ? anti-parallel 
AB7 1 2 ? anti-parallel 
AB7 2 3 ? anti-parallel 
AB7 3 4 ? anti-parallel 
AB8 1 2 ? parallel      
AB8 2 3 ? anti-parallel 
AB8 3 4 ? anti-parallel 
AB8 4 5 ? anti-parallel 
AB8 5 6 ? anti-parallel 
AB9 1 2 ? parallel      
AB9 2 3 ? anti-parallel 
AB9 3 4 ? anti-parallel 
AC1 1 2 ? anti-parallel 
AC1 2 3 ? anti-parallel 
AC1 3 4 ? anti-parallel 
AC2 1 2 ? anti-parallel 
AC2 2 3 ? anti-parallel 
AC2 3 4 ? anti-parallel 
AC3 1 2 ? anti-parallel 
AC3 2 3 ? anti-parallel 
AC4 1 2 ? anti-parallel 
AC4 2 3 ? anti-parallel 
AC4 3 4 ? anti-parallel 
AC5 1 2 ? parallel      
AC5 2 3 ? anti-parallel 
AC5 3 4 ? anti-parallel 
AC5 4 5 ? anti-parallel 
AC5 5 6 ? anti-parallel 
AC6 1 2 ? parallel      
AC6 2 3 ? anti-parallel 
AC6 3 4 ? anti-parallel 
AC7 1 2 ? anti-parallel 
AC8 1 2 ? anti-parallel 
AC8 2 3 ? anti-parallel 
AC8 3 4 ? anti-parallel 
AC9 1 2 ? anti-parallel 
AC9 2 3 ? anti-parallel 
AC9 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASN A 22  ? ILE A 26  ? ASN A 354 ILE A 358 
AA1 2 ASN A 62  ? ARG A 71  ? ASN A 394 ARG A 403 
AA1 3 PRO A 175 ? GLU A 184 ? PRO A 507 GLU A 516 
AA1 4 GLY A 99  ? ASN A 105 ? GLY A 431 ASN A 437 
AA1 5 THR A 44  ? TYR A 48  ? THR A 376 TYR A 380 
AA2 1 CYS A 29  ? VAL A 30  ? CYS A 361 VAL A 362 
AA2 2 VAL A 192 ? CYS A 193 ? VAL A 524 CYS A 525 
AA2 3 CYS A 59  ? PHE A 60  ? CYS A 391 PHE A 392 
AA3 1 LEU A 120 ? ARG A 122 ? LEU A 452 ARG A 454 
AA3 2 LEU A 160 ? SER A 162 ? LEU A 492 SER A 494 
AA4 1 TYR A 141 ? GLN A 142 ? TYR A 473 GLN A 474 
AA4 2 CYS A 156 ? TYR A 157 ? CYS A 488 TYR A 489 
AA5 1 GLN B 3   ? SER B 7   ? GLN F 3   SER F 7   
AA5 2 LEU B 18  ? SER B 25  ? LEU F 18  SER F 25  
AA5 3 THR B 77  ? MET B 82  ? THR F 77  MET F 82  
AA5 4 PHE B 67  ? ASP B 72  ? PHE F 67  ASP F 72  
AA6 1 LEU B 11  ? ILE B 12  ? LEU F 11  ILE F 12  
AA6 2 THR B 111 ? VAL B 115 ? THR F 107 VAL F 111 
AA6 3 ALA B 91  ? PHE B 99  ? ALA F 88  PHE F 96  
AA6 4 TYR B 33  ? ALA B 40  ? TYR F 33  ALA F 40  
AA6 5 GLY B 44  ? ILE B 51  ? GLY F 44  ILE F 51  
AA6 6 THR B 57  ? TYR B 59  ? THR F 57  TYR F 59  
AA7 1 LEU B 11  ? ILE B 12  ? LEU F 11  ILE F 12  
AA7 2 THR B 111 ? VAL B 115 ? THR F 107 VAL F 111 
AA7 3 ALA B 91  ? PHE B 99  ? ALA F 88  PHE F 96  
AA7 4 TYR B 103 ? TRP B 107 ? TYR F 100 TRP F 103 
AA8 1 SER B 124 ? LEU B 128 ? SER F 120 LEU F 124 
AA8 2 THR B 139 ? TYR B 149 ? THR F 135 TYR F 145 
AA8 3 TYR B 180 ? PRO B 189 ? TYR F 176 PRO F 185 
AA8 4 HIS B 168 ? THR B 169 ? HIS F 164 THR F 165 
AA9 1 THR B 135 ? SER B 136 ? THR F 131 SER F 132 
AA9 2 THR B 139 ? TYR B 149 ? THR F 135 TYR F 145 
AA9 3 TYR B 180 ? PRO B 189 ? TYR F 176 PRO F 185 
AA9 4 VAL B 173 ? LEU B 174 ? VAL F 169 LEU F 170 
AB1 1 THR B 155 ? TRP B 158 ? THR F 151 TRP F 154 
AB1 2 TYR B 198 ? HIS B 204 ? TYR F 194 HIS F 200 
AB1 3 THR B 209 ? VAL B 215 ? THR F 205 VAL F 211 
AB2 1 LEU C 4   ? SER C 7   ? LEU G 4   SER G 7   
AB2 2 ALA C 19  ? ALA C 25  ? ALA G 19  ALA G 25  
AB2 3 ASP C 70  ? ILE C 75  ? ASP G 70  ILE G 75  
AB2 4 PHE C 62  ? SER C 67  ? PHE G 62  SER G 67  
AB3 1 THR C 10  ? LEU C 13  ? THR G 10  LEU G 13  
AB3 2 THR C 102 ? ILE C 106 ? THR G 102 ILE G 106 
AB3 3 VAL C 85  ? GLN C 90  ? VAL G 85  GLN G 90  
AB3 4 LEU C 33  ? GLN C 38  ? LEU G 33  GLN G 38  
AB3 5 ARG C 45  ? TYR C 49  ? ARG G 45  TYR G 49  
AB3 6 SER C 53  ? ARG C 54  ? SER G 53  ARG G 54  
AB4 1 THR C 10  ? LEU C 13  ? THR G 10  LEU G 13  
AB4 2 THR C 102 ? ILE C 106 ? THR G 102 ILE G 106 
AB4 3 VAL C 85  ? GLN C 90  ? VAL G 85  GLN G 90  
AB4 4 THR C 97  ? PHE C 98  ? THR G 97  PHE G 98  
AB5 1 SER C 114 ? PHE C 118 ? SER G 114 PHE G 118 
AB5 2 THR C 129 ? PHE C 139 ? THR G 129 PHE G 139 
AB5 3 TYR C 173 ? SER C 182 ? TYR G 173 SER G 182 
AB5 4 SER C 159 ? VAL C 163 ? SER G 159 VAL G 163 
AB6 1 ALA C 153 ? LEU C 154 ? ALA G 153 LEU G 154 
AB6 2 LYS C 145 ? VAL C 150 ? LYS G 145 VAL G 150 
AB6 3 VAL C 191 ? THR C 197 ? VAL G 191 THR G 197 
AB6 4 VAL C 205 ? ASN C 210 ? VAL G 205 ASN G 210 
AB7 1 MET D 2   ? GLN D 6   ? MET H 2   GLN H 6   
AB7 2 LEU D 18  ? GLY D 26  ? LEU H 18  GLY H 26  
AB7 3 THR D 78  ? TRP D 83  ? THR H 77  TRP H 82  
AB7 4 THR D 69  ? ASP D 73  ? THR H 68  ASP H 72  
AB8 1 GLU D 10  ? LYS D 12  ? GLU H 10  LYS H 12  
AB8 2 THR D 113 ? VAL D 117 ? THR H 107 VAL H 111 
AB8 3 ALA D 92  ? GLY D 99  ? ALA H 88  GLY H 95  
AB8 4 TRP D 33  ? GLN D 39  ? TRP H 33  GLN H 39  
AB8 5 GLU D 46  ? TYR D 52  ? GLU H 46  TYR H 52  
AB8 6 GLU D 57  ? TYR D 60  ? GLU H 56  TYR H 59  
AB9 1 GLU D 10  ? LYS D 12  ? GLU H 10  LYS H 12  
AB9 2 THR D 113 ? VAL D 117 ? THR H 107 VAL H 111 
AB9 3 ALA D 92  ? GLY D 99  ? ALA H 88  GLY H 95  
AB9 4 VAL D 108 ? TRP D 109 ? VAL H 102 TRP H 103 
AC1 1 SER D 126 ? LEU D 130 ? SER H 120 LEU H 124 
AC1 2 THR D 141 ? TYR D 151 ? THR H 135 TYR H 145 
AC1 3 TYR D 182 ? PRO D 191 ? TYR H 176 PRO H 185 
AC1 4 HIS D 170 ? THR D 171 ? HIS H 164 THR H 165 
AC2 1 THR D 137 ? SER D 138 ? THR H 131 SER H 132 
AC2 2 THR D 141 ? TYR D 151 ? THR H 135 TYR H 145 
AC2 3 TYR D 182 ? PRO D 191 ? TYR H 176 PRO H 185 
AC2 4 VAL D 175 ? LEU D 176 ? VAL H 169 LEU H 170 
AC3 1 THR D 157 ? TRP D 160 ? THR H 151 TRP H 154 
AC3 2 TYR D 200 ? HIS D 206 ? TYR H 194 HIS H 200 
AC3 3 THR D 211 ? VAL D 217 ? THR H 205 VAL H 211 
AC4 1 LEU E 4   ? SER E 7   ? LEU L 4   SER L 7   
AC4 2 ALA E 19  ? SER E 25  ? ALA L 19  SER L 25  
AC4 3 ASP E 76  ? ILE E 81  ? ASP L 70  ILE L 75  
AC4 4 PHE E 68  ? SER E 73  ? PHE L 62  SER L 67  
AC5 1 SER E 10  ? SER E 14  ? SER L 10  SER L 14  
AC5 2 THR E 108 ? LYS E 113 ? THR L 102 LYS L 107 
AC5 3 ALA E 90  ? GLN E 96  ? ALA L 84  GLN L 90  
AC5 4 LEU E 39  ? GLN E 44  ? LEU L 33  GLN L 38  
AC5 5 LYS E 51  ? TYR E 55  ? LYS L 45  TYR L 49  
AC5 6 THR E 59  ? ARG E 60  ? THR L 53  ARG L 54  
AC6 1 SER E 10  ? SER E 14  ? SER L 10  SER L 14  
AC6 2 THR E 108 ? LYS E 113 ? THR L 102 LYS L 107 
AC6 3 ALA E 90  ? GLN E 96  ? ALA L 84  GLN L 90  
AC6 4 THR E 103 ? PHE E 104 ? THR L 97  PHE L 98  
AC7 1 LEU E 30  C TYR E 31  D LEU L 27  TYR L 27  
AC7 2 LYS E 36  ? ASN E 37  ? LYS L 30  ASN L 31  
AC8 1 SER E 120 ? PHE E 124 ? SER L 114 PHE L 118 
AC8 2 THR E 135 ? PHE E 145 ? THR L 129 PHE L 139 
AC8 3 TYR E 179 ? SER E 188 ? TYR L 173 SER L 182 
AC8 4 SER E 165 ? VAL E 169 ? SER L 159 VAL L 163 
AC9 1 ALA E 159 ? LEU E 160 ? ALA L 153 LEU L 154 
AC9 2 LYS E 151 ? VAL E 156 ? LYS L 145 VAL L 150 
AC9 3 VAL E 197 ? THR E 203 ? VAL L 191 THR L 197 
AC9 4 VAL E 211 ? ASN E 216 ? VAL L 205 ASN L 210 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LYS A 24  ? N LYS A 356 O ALA A 65  ? O ALA A 397 
AA1 2 3 N PHE A 68  ? N PHE A 400 O VAL A 178 ? O VAL A 510 
AA1 3 4 O VAL A 179 ? O VAL A 511 N ILE A 102 ? N ILE A 434 
AA1 4 5 O VAL A 101 ? O VAL A 433 N LYS A 46  ? N LYS A 378 
AA2 1 2 N CYS A 29  ? N CYS A 361 O CYS A 193 ? O CYS A 525 
AA2 2 3 O VAL A 192 ? O VAL A 524 N PHE A 60  ? N PHE A 392 
AA3 1 2 N TYR A 121 ? N TYR A 453 O GLN A 161 ? O GLN A 493 
AA4 1 2 N TYR A 141 ? N TYR A 473 O TYR A 157 ? O TYR A 489 
AA5 1 2 N GLN B 3   ? N GLN F 3   O SER B 25  ? O SER F 25  
AA5 2 3 N LEU B 18  ? N LEU F 18  O MET B 82  ? O MET F 82  
AA5 3 4 O TYR B 79  ? O TYR F 79  N SER B 70  ? N SER F 70  
AA6 1 2 N ILE B 12  ? N ILE F 12  O THR B 114 ? O THR F 110 
AA6 2 3 O THR B 111 ? O THR F 107 N TYR B 93  ? N TYR F 90  
AA6 3 4 O TYR B 94  ? O TYR F 91  N VAL B 37  ? N VAL F 37  
AA6 4 5 N ARG B 38  ? N ARG F 38  O GLU B 46  ? O GLU F 46  
AA6 5 6 N VAL B 50  ? N VAL F 50  O PHE B 58  ? O PHE F 58  
AA7 1 2 N ILE B 12  ? N ILE F 12  O THR B 114 ? O THR F 110 
AA7 2 3 O THR B 111 ? O THR F 107 N TYR B 93  ? N TYR F 90  
AA7 3 4 N PHE B 99  ? N PHE F 96  O TYR B 103 ? O TYR F 100 
AA8 1 2 N LEU B 128 ? N LEU F 124 O GLY B 143 ? O GLY F 139 
AA8 2 3 N ALA B 140 ? N ALA F 136 O VAL B 188 ? O VAL F 184 
AA8 3 4 O VAL B 185 ? O VAL F 181 N HIS B 168 ? N HIS F 164 
AA9 1 2 N SER B 136 ? N SER F 132 O THR B 139 ? O THR F 135 
AA9 2 3 N ALA B 140 ? N ALA F 136 O VAL B 188 ? O VAL F 184 
AA9 3 4 O SER B 181 ? O SER F 177 N VAL B 173 ? N VAL F 169 
AB1 1 2 N SER B 157 ? N SER F 153 O ASN B 201 ? O ASN F 197 
AB1 2 3 N VAL B 202 ? N VAL F 198 O VAL B 211 ? O VAL F 207 
AB2 1 2 N THR C 5   ? N THR G 5   O ARG C 24  ? O ARG G 24  
AB2 2 3 N LEU C 21  ? N LEU G 21  O LEU C 73  ? O LEU G 73  
AB2 3 4 O THR C 74  ? O THR G 74  N SER C 63  ? N SER G 63  
AB3 1 2 N LEU C 11  ? N LEU G 11  O GLU C 105 ? O GLU G 105 
AB3 2 3 O THR C 102 ? O THR G 102 N TYR C 86  ? N TYR G 86  
AB3 3 4 O VAL C 85  ? O VAL G 85  N GLN C 38  ? N GLN G 38  
AB3 4 5 N TRP C 35  ? N TRP G 35  O LEU C 47  ? O LEU G 47  
AB3 5 6 N TYR C 49  ? N TYR G 49  O SER C 53  ? O SER G 53  
AB4 1 2 N LEU C 11  ? N LEU G 11  O GLU C 105 ? O GLU G 105 
AB4 2 3 O THR C 102 ? O THR G 102 N TYR C 86  ? N TYR G 86  
AB4 3 4 N GLN C 90  ? N GLN G 90  O THR C 97  ? O THR G 97  
AB5 1 2 N PHE C 116 ? N PHE G 116 O LEU C 135 ? O LEU G 135 
AB5 2 3 N LEU C 136 ? N LEU G 136 O LEU C 175 ? O LEU G 175 
AB5 3 4 O THR C 178 ? O THR G 178 N GLN C 160 ? N GLN G 160 
AB6 1 2 O ALA C 153 ? O ALA G 153 N VAL C 150 ? N VAL G 150 
AB6 2 3 N LYS C 145 ? N LYS G 145 O THR C 197 ? O THR G 197 
AB6 3 4 N VAL C 196 ? N VAL G 196 O VAL C 205 ? O VAL G 205 
AB7 1 2 N VAL D 5   ? N VAL H 5   O LYS D 23  ? O LYS H 23  
AB7 2 3 N CYS D 22  ? N CYS H 22  O ALA D 79  ? O ALA H 78  
AB7 3 4 O THR D 78  ? O THR H 77  N ASP D 73  ? N ASP H 72  
AB8 1 2 N LYS D 12  ? N LYS H 12  O THR D 116 ? O THR H 110 
AB8 2 3 O THR D 113 ? O THR H 107 N TYR D 94  ? N TYR H 90  
AB8 3 4 O GLY D 99  ? O GLY H 95  N TRP D 33  ? N TRP H 33  
AB8 4 5 N ARG D 38  ? N ARG H 38  O GLU D 46  ? O GLU H 46  
AB8 5 6 N ILE D 50  ? N ILE H 50  O ARG D 59  ? O ARG H 58  
AB9 1 2 N LYS D 12  ? N LYS H 12  O THR D 116 ? O THR H 110 
AB9 2 3 O THR D 113 ? O THR H 107 N TYR D 94  ? N TYR H 90  
AB9 3 4 N GLY D 98  ? N GLY H 94  O VAL D 108 ? O VAL H 102 
AC1 1 2 N PHE D 128 ? N PHE H 122 O LEU D 147 ? O LEU H 141 
AC1 2 3 N VAL D 148 ? N VAL H 142 O LEU D 184 ? O LEU H 178 
AC1 3 4 O VAL D 187 ? O VAL H 181 N HIS D 170 ? N HIS H 164 
AC2 1 2 N SER D 138 ? N SER H 132 O THR D 141 ? O THR H 135 
AC2 2 3 N VAL D 148 ? N VAL H 142 O LEU D 184 ? O LEU H 178 
AC2 3 4 O SER D 183 ? O SER H 177 N VAL D 175 ? N VAL H 169 
AC3 1 2 N SER D 159 ? N SER H 153 O ASN D 203 ? O ASN H 197 
AC3 2 3 N CYS D 202 ? N CYS H 196 O LYS D 215 ? O LYS H 209 
AC4 1 2 N THR E 5   ? N THR L 5   O LYS E 24  ? O LYS L 24  
AC4 2 3 N ILE E 21  ? N ILE L 21  O LEU E 79  ? O LEU L 73  
AC4 3 4 O THR E 80  ? O THR L 74  N SER E 69  ? N SER L 63  
AC5 1 2 N LEU E 11  ? N LEU L 11  O LYS E 109 ? O LYS L 103 
AC5 2 3 O THR E 108 ? O THR L 102 N TYR E 92  ? N TYR L 86  
AC5 3 4 O TYR E 93  ? O TYR L 87  N TYR E 42  ? N TYR L 36  
AC5 4 5 N GLN E 43  ? N GLN L 37  O LYS E 51  ? O LYS L 45  
AC5 5 6 N TYR E 55  ? N TYR L 49  O THR E 59  ? O THR L 53  
AC6 1 2 N LEU E 11  ? N LEU L 11  O LYS E 109 ? O LYS L 103 
AC6 2 3 O THR E 108 ? O THR L 102 N TYR E 92  ? N TYR L 86  
AC6 3 4 N GLN E 96  ? N GLN L 90  O THR E 103 ? O THR L 97  
AC7 1 2 N TYR E 31  D N TYR L 27  O LYS E 36  ? O LYS L 30  
AC8 1 2 N PHE E 122 ? N PHE L 116 O LEU E 141 ? O LEU L 135 
AC8 2 3 N ALA E 136 ? N ALA L 130 O LEU E 187 ? O LEU L 181 
AC8 3 4 O THR E 184 ? O THR L 178 N GLN E 166 ? N GLN L 160 
AC9 1 2 O ALA E 159 ? O ALA L 153 N VAL E 156 ? N VAL L 150 
AC9 2 3 N GLN E 153 ? N GLN L 147 O GLU E 201 ? O GLU L 195 
AC9 3 4 N CYS E 200 ? N CYS L 194 O LYS E 213 ? O LYS L 207 
# 
_pdbx_entry_details.entry_id                   9CPQ 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 428 ? ? -97.38  32.73   
2 1 ASP F 144 ? ? 60.73   64.60   
3 1 ASP G 82  ? ? -78.38  -155.18 
4 1 ALA G 84  ? ? -120.93 -167.59 
5 1 ALA L 51  ? ? 64.60   -14.29  
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A THR 333 ? A THR 1   
2  1 Y 1 A LEU 518 ? A LEU 186 
3  1 Y 1 A HIS 519 ? A HIS 187 
4  1 Y 1 A LYS 529 ? A LYS 197 
5  1 Y 1 A SER 530 ? A SER 198 
6  1 Y 1 A GLY 531 ? A GLY 199 
7  1 Y 1 A HIS 532 ? A HIS 200 
8  1 Y 1 A HIS 533 ? A HIS 201 
9  1 Y 1 A HIS 534 ? A HIS 202 
10 1 Y 1 A HIS 535 ? A HIS 203 
11 1 Y 1 A HIS 536 ? A HIS 204 
12 1 Y 1 A HIS 537 ? A HIS 205 
13 1 Y 1 F SER 215 ? B SER 219 
14 1 Y 1 F CYS 216 ? B CYS 220 
15 1 Y 1 G GLU 213 ? C GLU 213 
16 1 Y 1 G CYS 214 ? C CYS 214 
17 1 Y 1 H SER 215 ? D SER 221 
18 1 Y 1 H CYS 216 ? D CYS 222 
19 1 Y 1 L GLY 212 ? E GLY 218 
20 1 Y 1 L GLU 213 ? E GLU 219 
21 1 Y 1 L CYS 214 ? E CYS 220 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
BMA C1   C N R 74  
BMA C2   C N S 75  
BMA C3   C N S 76  
BMA C4   C N S 77  
BMA C5   C N R 78  
BMA C6   C N N 79  
BMA O1   O N N 80  
BMA O2   O N N 81  
BMA O3   O N N 82  
BMA O4   O N N 83  
BMA O5   O N N 84  
BMA O6   O N N 85  
BMA H1   H N N 86  
BMA H2   H N N 87  
BMA H3   H N N 88  
BMA H4   H N N 89  
BMA H5   H N N 90  
BMA H61  H N N 91  
BMA H62  H N N 92  
BMA HO1  H N N 93  
BMA HO2  H N N 94  
BMA HO3  H N N 95  
BMA HO4  H N N 96  
BMA HO6  H N N 97  
CIT C1   C N N 98  
CIT O1   O N N 99  
CIT O2   O N N 100 
CIT C2   C N N 101 
CIT C3   C N N 102 
CIT O7   O N N 103 
CIT C4   C N N 104 
CIT C5   C N N 105 
CIT O3   O N N 106 
CIT O4   O N N 107 
CIT C6   C N N 108 
CIT O5   O N N 109 
CIT O6   O N N 110 
CIT HO2  H N N 111 
CIT H21  H N N 112 
CIT H22  H N N 113 
CIT HO7  H N N 114 
CIT H41  H N N 115 
CIT H42  H N N 116 
CIT HO4  H N N 117 
CIT HO6  H N N 118 
CYS N    N N N 119 
CYS CA   C N R 120 
CYS C    C N N 121 
CYS O    O N N 122 
CYS CB   C N N 123 
CYS SG   S N N 124 
CYS OXT  O N N 125 
CYS H    H N N 126 
CYS H2   H N N 127 
CYS HA   H N N 128 
CYS HB2  H N N 129 
CYS HB3  H N N 130 
CYS HG   H N N 131 
CYS HXT  H N N 132 
GLN N    N N N 133 
GLN CA   C N S 134 
GLN C    C N N 135 
GLN O    O N N 136 
GLN CB   C N N 137 
GLN CG   C N N 138 
GLN CD   C N N 139 
GLN OE1  O N N 140 
GLN NE2  N N N 141 
GLN OXT  O N N 142 
GLN H    H N N 143 
GLN H2   H N N 144 
GLN HA   H N N 145 
GLN HB2  H N N 146 
GLN HB3  H N N 147 
GLN HG2  H N N 148 
GLN HG3  H N N 149 
GLN HE21 H N N 150 
GLN HE22 H N N 151 
GLN HXT  H N N 152 
GLU N    N N N 153 
GLU CA   C N S 154 
GLU C    C N N 155 
GLU O    O N N 156 
GLU CB   C N N 157 
GLU CG   C N N 158 
GLU CD   C N N 159 
GLU OE1  O N N 160 
GLU OE2  O N N 161 
GLU OXT  O N N 162 
GLU H    H N N 163 
GLU H2   H N N 164 
GLU HA   H N N 165 
GLU HB2  H N N 166 
GLU HB3  H N N 167 
GLU HG2  H N N 168 
GLU HG3  H N N 169 
GLU HE2  H N N 170 
GLU HXT  H N N 171 
GLY N    N N N 172 
GLY CA   C N N 173 
GLY C    C N N 174 
GLY O    O N N 175 
GLY OXT  O N N 176 
GLY H    H N N 177 
GLY H2   H N N 178 
GLY HA2  H N N 179 
GLY HA3  H N N 180 
GLY HXT  H N N 181 
HIS N    N N N 182 
HIS CA   C N S 183 
HIS C    C N N 184 
HIS O    O N N 185 
HIS CB   C N N 186 
HIS CG   C Y N 187 
HIS ND1  N Y N 188 
HIS CD2  C Y N 189 
HIS CE1  C Y N 190 
HIS NE2  N Y N 191 
HIS OXT  O N N 192 
HIS H    H N N 193 
HIS H2   H N N 194 
HIS HA   H N N 195 
HIS HB2  H N N 196 
HIS HB3  H N N 197 
HIS HD1  H N N 198 
HIS HD2  H N N 199 
HIS HE1  H N N 200 
HIS HE2  H N N 201 
HIS HXT  H N N 202 
HOH O    O N N 203 
HOH H1   H N N 204 
HOH H2   H N N 205 
ILE N    N N N 206 
ILE CA   C N S 207 
ILE C    C N N 208 
ILE O    O N N 209 
ILE CB   C N S 210 
ILE CG1  C N N 211 
ILE CG2  C N N 212 
ILE CD1  C N N 213 
ILE OXT  O N N 214 
ILE H    H N N 215 
ILE H2   H N N 216 
ILE HA   H N N 217 
ILE HB   H N N 218 
ILE HG12 H N N 219 
ILE HG13 H N N 220 
ILE HG21 H N N 221 
ILE HG22 H N N 222 
ILE HG23 H N N 223 
ILE HD11 H N N 224 
ILE HD12 H N N 225 
ILE HD13 H N N 226 
ILE HXT  H N N 227 
LEU N    N N N 228 
LEU CA   C N S 229 
LEU C    C N N 230 
LEU O    O N N 231 
LEU CB   C N N 232 
LEU CG   C N N 233 
LEU CD1  C N N 234 
LEU CD2  C N N 235 
LEU OXT  O N N 236 
LEU H    H N N 237 
LEU H2   H N N 238 
LEU HA   H N N 239 
LEU HB2  H N N 240 
LEU HB3  H N N 241 
LEU HG   H N N 242 
LEU HD11 H N N 243 
LEU HD12 H N N 244 
LEU HD13 H N N 245 
LEU HD21 H N N 246 
LEU HD22 H N N 247 
LEU HD23 H N N 248 
LEU HXT  H N N 249 
LYS N    N N N 250 
LYS CA   C N S 251 
LYS C    C N N 252 
LYS O    O N N 253 
LYS CB   C N N 254 
LYS CG   C N N 255 
LYS CD   C N N 256 
LYS CE   C N N 257 
LYS NZ   N N N 258 
LYS OXT  O N N 259 
LYS H    H N N 260 
LYS H2   H N N 261 
LYS HA   H N N 262 
LYS HB2  H N N 263 
LYS HB3  H N N 264 
LYS HG2  H N N 265 
LYS HG3  H N N 266 
LYS HD2  H N N 267 
LYS HD3  H N N 268 
LYS HE2  H N N 269 
LYS HE3  H N N 270 
LYS HZ1  H N N 271 
LYS HZ2  H N N 272 
LYS HZ3  H N N 273 
LYS HXT  H N N 274 
MET N    N N N 275 
MET CA   C N S 276 
MET C    C N N 277 
MET O    O N N 278 
MET CB   C N N 279 
MET CG   C N N 280 
MET SD   S N N 281 
MET CE   C N N 282 
MET OXT  O N N 283 
MET H    H N N 284 
MET H2   H N N 285 
MET HA   H N N 286 
MET HB2  H N N 287 
MET HB3  H N N 288 
MET HG2  H N N 289 
MET HG3  H N N 290 
MET HE1  H N N 291 
MET HE2  H N N 292 
MET HE3  H N N 293 
MET HXT  H N N 294 
NAG C1   C N R 295 
NAG C2   C N R 296 
NAG C3   C N R 297 
NAG C4   C N S 298 
NAG C5   C N R 299 
NAG C6   C N N 300 
NAG C7   C N N 301 
NAG C8   C N N 302 
NAG N2   N N N 303 
NAG O1   O N N 304 
NAG O3   O N N 305 
NAG O4   O N N 306 
NAG O5   O N N 307 
NAG O6   O N N 308 
NAG O7   O N N 309 
NAG H1   H N N 310 
NAG H2   H N N 311 
NAG H3   H N N 312 
NAG H4   H N N 313 
NAG H5   H N N 314 
NAG H61  H N N 315 
NAG H62  H N N 316 
NAG H81  H N N 317 
NAG H82  H N N 318 
NAG H83  H N N 319 
NAG HN2  H N N 320 
NAG HO1  H N N 321 
NAG HO3  H N N 322 
NAG HO4  H N N 323 
NAG HO6  H N N 324 
PHE N    N N N 325 
PHE CA   C N S 326 
PHE C    C N N 327 
PHE O    O N N 328 
PHE CB   C N N 329 
PHE CG   C Y N 330 
PHE CD1  C Y N 331 
PHE CD2  C Y N 332 
PHE CE1  C Y N 333 
PHE CE2  C Y N 334 
PHE CZ   C Y N 335 
PHE OXT  O N N 336 
PHE H    H N N 337 
PHE H2   H N N 338 
PHE HA   H N N 339 
PHE HB2  H N N 340 
PHE HB3  H N N 341 
PHE HD1  H N N 342 
PHE HD2  H N N 343 
PHE HE1  H N N 344 
PHE HE2  H N N 345 
PHE HZ   H N N 346 
PHE HXT  H N N 347 
PRO N    N N N 348 
PRO CA   C N S 349 
PRO C    C N N 350 
PRO O    O N N 351 
PRO CB   C N N 352 
PRO CG   C N N 353 
PRO CD   C N N 354 
PRO OXT  O N N 355 
PRO H    H N N 356 
PRO HA   H N N 357 
PRO HB2  H N N 358 
PRO HB3  H N N 359 
PRO HG2  H N N 360 
PRO HG3  H N N 361 
PRO HD2  H N N 362 
PRO HD3  H N N 363 
PRO HXT  H N N 364 
SER N    N N N 365 
SER CA   C N S 366 
SER C    C N N 367 
SER O    O N N 368 
SER CB   C N N 369 
SER OG   O N N 370 
SER OXT  O N N 371 
SER H    H N N 372 
SER H2   H N N 373 
SER HA   H N N 374 
SER HB2  H N N 375 
SER HB3  H N N 376 
SER HG   H N N 377 
SER HXT  H N N 378 
THR N    N N N 379 
THR CA   C N S 380 
THR C    C N N 381 
THR O    O N N 382 
THR CB   C N R 383 
THR OG1  O N N 384 
THR CG2  C N N 385 
THR OXT  O N N 386 
THR H    H N N 387 
THR H2   H N N 388 
THR HA   H N N 389 
THR HB   H N N 390 
THR HG1  H N N 391 
THR HG21 H N N 392 
THR HG22 H N N 393 
THR HG23 H N N 394 
THR HXT  H N N 395 
TRP N    N N N 396 
TRP CA   C N S 397 
TRP C    C N N 398 
TRP O    O N N 399 
TRP CB   C N N 400 
TRP CG   C Y N 401 
TRP CD1  C Y N 402 
TRP CD2  C Y N 403 
TRP NE1  N Y N 404 
TRP CE2  C Y N 405 
TRP CE3  C Y N 406 
TRP CZ2  C Y N 407 
TRP CZ3  C Y N 408 
TRP CH2  C Y N 409 
TRP OXT  O N N 410 
TRP H    H N N 411 
TRP H2   H N N 412 
TRP HA   H N N 413 
TRP HB2  H N N 414 
TRP HB3  H N N 415 
TRP HD1  H N N 416 
TRP HE1  H N N 417 
TRP HE3  H N N 418 
TRP HZ2  H N N 419 
TRP HZ3  H N N 420 
TRP HH2  H N N 421 
TRP HXT  H N N 422 
TYR N    N N N 423 
TYR CA   C N S 424 
TYR C    C N N 425 
TYR O    O N N 426 
TYR CB   C N N 427 
TYR CG   C Y N 428 
TYR CD1  C Y N 429 
TYR CD2  C Y N 430 
TYR CE1  C Y N 431 
TYR CE2  C Y N 432 
TYR CZ   C Y N 433 
TYR OH   O N N 434 
TYR OXT  O N N 435 
TYR H    H N N 436 
TYR H2   H N N 437 
TYR HA   H N N 438 
TYR HB2  H N N 439 
TYR HB3  H N N 440 
TYR HD1  H N N 441 
TYR HD2  H N N 442 
TYR HE1  H N N 443 
TYR HE2  H N N 444 
TYR HH   H N N 445 
TYR HXT  H N N 446 
VAL N    N N N 447 
VAL CA   C N S 448 
VAL C    C N N 449 
VAL O    O N N 450 
VAL CB   C N N 451 
VAL CG1  C N N 452 
VAL CG2  C N N 453 
VAL OXT  O N N 454 
VAL H    H N N 455 
VAL H2   H N N 456 
VAL HA   H N N 457 
VAL HB   H N N 458 
VAL HG11 H N N 459 
VAL HG12 H N N 460 
VAL HG13 H N N 461 
VAL HG21 H N N 462 
VAL HG22 H N N 463 
VAL HG23 H N N 464 
VAL HXT  H N N 465 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
BMA C1  C2   sing N N 70  
BMA C1  O1   sing N N 71  
BMA C1  O5   sing N N 72  
BMA C1  H1   sing N N 73  
BMA C2  C3   sing N N 74  
BMA C2  O2   sing N N 75  
BMA C2  H2   sing N N 76  
BMA C3  C4   sing N N 77  
BMA C3  O3   sing N N 78  
BMA C3  H3   sing N N 79  
BMA C4  C5   sing N N 80  
BMA C4  O4   sing N N 81  
BMA C4  H4   sing N N 82  
BMA C5  C6   sing N N 83  
BMA C5  O5   sing N N 84  
BMA C5  H5   sing N N 85  
BMA C6  O6   sing N N 86  
BMA C6  H61  sing N N 87  
BMA C6  H62  sing N N 88  
BMA O1  HO1  sing N N 89  
BMA O2  HO2  sing N N 90  
BMA O3  HO3  sing N N 91  
BMA O4  HO4  sing N N 92  
BMA O6  HO6  sing N N 93  
CIT C1  O1   doub N N 94  
CIT C1  O2   sing N N 95  
CIT C1  C2   sing N N 96  
CIT O2  HO2  sing N N 97  
CIT C2  C3   sing N N 98  
CIT C2  H21  sing N N 99  
CIT C2  H22  sing N N 100 
CIT C3  O7   sing N N 101 
CIT C3  C4   sing N N 102 
CIT C3  C6   sing N N 103 
CIT O7  HO7  sing N N 104 
CIT C4  C5   sing N N 105 
CIT C4  H41  sing N N 106 
CIT C4  H42  sing N N 107 
CIT C5  O3   doub N N 108 
CIT C5  O4   sing N N 109 
CIT O4  HO4  sing N N 110 
CIT C6  O5   doub N N 111 
CIT C6  O6   sing N N 112 
CIT O6  HO6  sing N N 113 
CYS N   CA   sing N N 114 
CYS N   H    sing N N 115 
CYS N   H2   sing N N 116 
CYS CA  C    sing N N 117 
CYS CA  CB   sing N N 118 
CYS CA  HA   sing N N 119 
CYS C   O    doub N N 120 
CYS C   OXT  sing N N 121 
CYS CB  SG   sing N N 122 
CYS CB  HB2  sing N N 123 
CYS CB  HB3  sing N N 124 
CYS SG  HG   sing N N 125 
CYS OXT HXT  sing N N 126 
GLN N   CA   sing N N 127 
GLN N   H    sing N N 128 
GLN N   H2   sing N N 129 
GLN CA  C    sing N N 130 
GLN CA  CB   sing N N 131 
GLN CA  HA   sing N N 132 
GLN C   O    doub N N 133 
GLN C   OXT  sing N N 134 
GLN CB  CG   sing N N 135 
GLN CB  HB2  sing N N 136 
GLN CB  HB3  sing N N 137 
GLN CG  CD   sing N N 138 
GLN CG  HG2  sing N N 139 
GLN CG  HG3  sing N N 140 
GLN CD  OE1  doub N N 141 
GLN CD  NE2  sing N N 142 
GLN NE2 HE21 sing N N 143 
GLN NE2 HE22 sing N N 144 
GLN OXT HXT  sing N N 145 
GLU N   CA   sing N N 146 
GLU N   H    sing N N 147 
GLU N   H2   sing N N 148 
GLU CA  C    sing N N 149 
GLU CA  CB   sing N N 150 
GLU CA  HA   sing N N 151 
GLU C   O    doub N N 152 
GLU C   OXT  sing N N 153 
GLU CB  CG   sing N N 154 
GLU CB  HB2  sing N N 155 
GLU CB  HB3  sing N N 156 
GLU CG  CD   sing N N 157 
GLU CG  HG2  sing N N 158 
GLU CG  HG3  sing N N 159 
GLU CD  OE1  doub N N 160 
GLU CD  OE2  sing N N 161 
GLU OE2 HE2  sing N N 162 
GLU OXT HXT  sing N N 163 
GLY N   CA   sing N N 164 
GLY N   H    sing N N 165 
GLY N   H2   sing N N 166 
GLY CA  C    sing N N 167 
GLY CA  HA2  sing N N 168 
GLY CA  HA3  sing N N 169 
GLY C   O    doub N N 170 
GLY C   OXT  sing N N 171 
GLY OXT HXT  sing N N 172 
HIS N   CA   sing N N 173 
HIS N   H    sing N N 174 
HIS N   H2   sing N N 175 
HIS CA  C    sing N N 176 
HIS CA  CB   sing N N 177 
HIS CA  HA   sing N N 178 
HIS C   O    doub N N 179 
HIS C   OXT  sing N N 180 
HIS CB  CG   sing N N 181 
HIS CB  HB2  sing N N 182 
HIS CB  HB3  sing N N 183 
HIS CG  ND1  sing Y N 184 
HIS CG  CD2  doub Y N 185 
HIS ND1 CE1  doub Y N 186 
HIS ND1 HD1  sing N N 187 
HIS CD2 NE2  sing Y N 188 
HIS CD2 HD2  sing N N 189 
HIS CE1 NE2  sing Y N 190 
HIS CE1 HE1  sing N N 191 
HIS NE2 HE2  sing N N 192 
HIS OXT HXT  sing N N 193 
HOH O   H1   sing N N 194 
HOH O   H2   sing N N 195 
ILE N   CA   sing N N 196 
ILE N   H    sing N N 197 
ILE N   H2   sing N N 198 
ILE CA  C    sing N N 199 
ILE CA  CB   sing N N 200 
ILE CA  HA   sing N N 201 
ILE C   O    doub N N 202 
ILE C   OXT  sing N N 203 
ILE CB  CG1  sing N N 204 
ILE CB  CG2  sing N N 205 
ILE CB  HB   sing N N 206 
ILE CG1 CD1  sing N N 207 
ILE CG1 HG12 sing N N 208 
ILE CG1 HG13 sing N N 209 
ILE CG2 HG21 sing N N 210 
ILE CG2 HG22 sing N N 211 
ILE CG2 HG23 sing N N 212 
ILE CD1 HD11 sing N N 213 
ILE CD1 HD12 sing N N 214 
ILE CD1 HD13 sing N N 215 
ILE OXT HXT  sing N N 216 
LEU N   CA   sing N N 217 
LEU N   H    sing N N 218 
LEU N   H2   sing N N 219 
LEU CA  C    sing N N 220 
LEU CA  CB   sing N N 221 
LEU CA  HA   sing N N 222 
LEU C   O    doub N N 223 
LEU C   OXT  sing N N 224 
LEU CB  CG   sing N N 225 
LEU CB  HB2  sing N N 226 
LEU CB  HB3  sing N N 227 
LEU CG  CD1  sing N N 228 
LEU CG  CD2  sing N N 229 
LEU CG  HG   sing N N 230 
LEU CD1 HD11 sing N N 231 
LEU CD1 HD12 sing N N 232 
LEU CD1 HD13 sing N N 233 
LEU CD2 HD21 sing N N 234 
LEU CD2 HD22 sing N N 235 
LEU CD2 HD23 sing N N 236 
LEU OXT HXT  sing N N 237 
LYS N   CA   sing N N 238 
LYS N   H    sing N N 239 
LYS N   H2   sing N N 240 
LYS CA  C    sing N N 241 
LYS CA  CB   sing N N 242 
LYS CA  HA   sing N N 243 
LYS C   O    doub N N 244 
LYS C   OXT  sing N N 245 
LYS CB  CG   sing N N 246 
LYS CB  HB2  sing N N 247 
LYS CB  HB3  sing N N 248 
LYS CG  CD   sing N N 249 
LYS CG  HG2  sing N N 250 
LYS CG  HG3  sing N N 251 
LYS CD  CE   sing N N 252 
LYS CD  HD2  sing N N 253 
LYS CD  HD3  sing N N 254 
LYS CE  NZ   sing N N 255 
LYS CE  HE2  sing N N 256 
LYS CE  HE3  sing N N 257 
LYS NZ  HZ1  sing N N 258 
LYS NZ  HZ2  sing N N 259 
LYS NZ  HZ3  sing N N 260 
LYS OXT HXT  sing N N 261 
MET N   CA   sing N N 262 
MET N   H    sing N N 263 
MET N   H2   sing N N 264 
MET CA  C    sing N N 265 
MET CA  CB   sing N N 266 
MET CA  HA   sing N N 267 
MET C   O    doub N N 268 
MET C   OXT  sing N N 269 
MET CB  CG   sing N N 270 
MET CB  HB2  sing N N 271 
MET CB  HB3  sing N N 272 
MET CG  SD   sing N N 273 
MET CG  HG2  sing N N 274 
MET CG  HG3  sing N N 275 
MET SD  CE   sing N N 276 
MET CE  HE1  sing N N 277 
MET CE  HE2  sing N N 278 
MET CE  HE3  sing N N 279 
MET OXT HXT  sing N N 280 
NAG C1  C2   sing N N 281 
NAG C1  O1   sing N N 282 
NAG C1  O5   sing N N 283 
NAG C1  H1   sing N N 284 
NAG C2  C3   sing N N 285 
NAG C2  N2   sing N N 286 
NAG C2  H2   sing N N 287 
NAG C3  C4   sing N N 288 
NAG C3  O3   sing N N 289 
NAG C3  H3   sing N N 290 
NAG C4  C5   sing N N 291 
NAG C4  O4   sing N N 292 
NAG C4  H4   sing N N 293 
NAG C5  C6   sing N N 294 
NAG C5  O5   sing N N 295 
NAG C5  H5   sing N N 296 
NAG C6  O6   sing N N 297 
NAG C6  H61  sing N N 298 
NAG C6  H62  sing N N 299 
NAG C7  C8   sing N N 300 
NAG C7  N2   sing N N 301 
NAG C7  O7   doub N N 302 
NAG C8  H81  sing N N 303 
NAG C8  H82  sing N N 304 
NAG C8  H83  sing N N 305 
NAG N2  HN2  sing N N 306 
NAG O1  HO1  sing N N 307 
NAG O3  HO3  sing N N 308 
NAG O4  HO4  sing N N 309 
NAG O6  HO6  sing N N 310 
PHE N   CA   sing N N 311 
PHE N   H    sing N N 312 
PHE N   H2   sing N N 313 
PHE CA  C    sing N N 314 
PHE CA  CB   sing N N 315 
PHE CA  HA   sing N N 316 
PHE C   O    doub N N 317 
PHE C   OXT  sing N N 318 
PHE CB  CG   sing N N 319 
PHE CB  HB2  sing N N 320 
PHE CB  HB3  sing N N 321 
PHE CG  CD1  doub Y N 322 
PHE CG  CD2  sing Y N 323 
PHE CD1 CE1  sing Y N 324 
PHE CD1 HD1  sing N N 325 
PHE CD2 CE2  doub Y N 326 
PHE CD2 HD2  sing N N 327 
PHE CE1 CZ   doub Y N 328 
PHE CE1 HE1  sing N N 329 
PHE CE2 CZ   sing Y N 330 
PHE CE2 HE2  sing N N 331 
PHE CZ  HZ   sing N N 332 
PHE OXT HXT  sing N N 333 
PRO N   CA   sing N N 334 
PRO N   CD   sing N N 335 
PRO N   H    sing N N 336 
PRO CA  C    sing N N 337 
PRO CA  CB   sing N N 338 
PRO CA  HA   sing N N 339 
PRO C   O    doub N N 340 
PRO C   OXT  sing N N 341 
PRO CB  CG   sing N N 342 
PRO CB  HB2  sing N N 343 
PRO CB  HB3  sing N N 344 
PRO CG  CD   sing N N 345 
PRO CG  HG2  sing N N 346 
PRO CG  HG3  sing N N 347 
PRO CD  HD2  sing N N 348 
PRO CD  HD3  sing N N 349 
PRO OXT HXT  sing N N 350 
SER N   CA   sing N N 351 
SER N   H    sing N N 352 
SER N   H2   sing N N 353 
SER CA  C    sing N N 354 
SER CA  CB   sing N N 355 
SER CA  HA   sing N N 356 
SER C   O    doub N N 357 
SER C   OXT  sing N N 358 
SER CB  OG   sing N N 359 
SER CB  HB2  sing N N 360 
SER CB  HB3  sing N N 361 
SER OG  HG   sing N N 362 
SER OXT HXT  sing N N 363 
THR N   CA   sing N N 364 
THR N   H    sing N N 365 
THR N   H2   sing N N 366 
THR CA  C    sing N N 367 
THR CA  CB   sing N N 368 
THR CA  HA   sing N N 369 
THR C   O    doub N N 370 
THR C   OXT  sing N N 371 
THR CB  OG1  sing N N 372 
THR CB  CG2  sing N N 373 
THR CB  HB   sing N N 374 
THR OG1 HG1  sing N N 375 
THR CG2 HG21 sing N N 376 
THR CG2 HG22 sing N N 377 
THR CG2 HG23 sing N N 378 
THR OXT HXT  sing N N 379 
TRP N   CA   sing N N 380 
TRP N   H    sing N N 381 
TRP N   H2   sing N N 382 
TRP CA  C    sing N N 383 
TRP CA  CB   sing N N 384 
TRP CA  HA   sing N N 385 
TRP C   O    doub N N 386 
TRP C   OXT  sing N N 387 
TRP CB  CG   sing N N 388 
TRP CB  HB2  sing N N 389 
TRP CB  HB3  sing N N 390 
TRP CG  CD1  doub Y N 391 
TRP CG  CD2  sing Y N 392 
TRP CD1 NE1  sing Y N 393 
TRP CD1 HD1  sing N N 394 
TRP CD2 CE2  doub Y N 395 
TRP CD2 CE3  sing Y N 396 
TRP NE1 CE2  sing Y N 397 
TRP NE1 HE1  sing N N 398 
TRP CE2 CZ2  sing Y N 399 
TRP CE3 CZ3  doub Y N 400 
TRP CE3 HE3  sing N N 401 
TRP CZ2 CH2  doub Y N 402 
TRP CZ2 HZ2  sing N N 403 
TRP CZ3 CH2  sing Y N 404 
TRP CZ3 HZ3  sing N N 405 
TRP CH2 HH2  sing N N 406 
TRP OXT HXT  sing N N 407 
TYR N   CA   sing N N 408 
TYR N   H    sing N N 409 
TYR N   H2   sing N N 410 
TYR CA  C    sing N N 411 
TYR CA  CB   sing N N 412 
TYR CA  HA   sing N N 413 
TYR C   O    doub N N 414 
TYR C   OXT  sing N N 415 
TYR CB  CG   sing N N 416 
TYR CB  HB2  sing N N 417 
TYR CB  HB3  sing N N 418 
TYR CG  CD1  doub Y N 419 
TYR CG  CD2  sing Y N 420 
TYR CD1 CE1  sing Y N 421 
TYR CD1 HD1  sing N N 422 
TYR CD2 CE2  doub Y N 423 
TYR CD2 HD2  sing N N 424 
TYR CE1 CZ   doub Y N 425 
TYR CE1 HE1  sing N N 426 
TYR CE2 CZ   sing Y N 427 
TYR CE2 HE2  sing N N 428 
TYR CZ  OH   sing N N 429 
TYR OH  HH   sing N N 430 
TYR OXT HXT  sing N N 431 
VAL N   CA   sing N N 432 
VAL N   H    sing N N 433 
VAL N   H2   sing N N 434 
VAL CA  C    sing N N 435 
VAL CA  CB   sing N N 436 
VAL CA  HA   sing N N 437 
VAL C   O    doub N N 438 
VAL C   OXT  sing N N 439 
VAL CB  CG1  sing N N 440 
VAL CB  CG2  sing N N 441 
VAL CB  HB   sing N N 442 
VAL CG1 HG11 sing N N 443 
VAL CG1 HG12 sing N N 444 
VAL CG1 HG13 sing N N 445 
VAL CG2 HG21 sing N N 446 
VAL CG2 HG22 sing N N 447 
VAL CG2 HG23 sing N N 448 
VAL OXT HXT  sing N N 449 
# 
_pdbx_audit_support.funding_organization   'Bill & Melinda Gates Foundation' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           INV-004923 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
6 NAG 1 n 
6 NAG 2 n 
6 BMA 3 n 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8GF2 
_pdbx_initial_refinement_model.details          ? 
# 
_atom_sites.entry_id                    9CPQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.009098 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009098 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.004441 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . ASN A 1 2   ? 28.495  19.021  33.217  1.00 69.26  ? 334 ASN A N   1 
ATOM   2    C CA  . ASN A 1 2   ? 28.799  17.980  32.241  1.00 75.19  ? 334 ASN A CA  1 
ATOM   3    C C   . ASN A 1 2   ? 27.812  16.815  32.318  1.00 79.74  ? 334 ASN A C   1 
ATOM   4    O O   . ASN A 1 2   ? 27.521  16.179  31.307  1.00 80.03  ? 334 ASN A O   1 
ATOM   5    C CB  . ASN A 1 2   ? 30.231  17.472  32.433  1.00 75.40  ? 334 ASN A CB  1 
ATOM   6    C CG  . ASN A 1 2   ? 31.198  18.065  31.424  1.00 79.94  ? 334 ASN A CG  1 
ATOM   7    O OD1 . ASN A 1 2   ? 30.863  19.009  30.708  1.00 72.72  ? 334 ASN A OD1 1 
ATOM   8    N ND2 . ASN A 1 2   ? 32.403  17.512  31.363  1.00 66.76  ? 334 ASN A ND2 1 
ATOM   9    N N   . LEU A 1 3   ? 27.296  16.540  33.514  1.00 78.12  ? 335 LEU A N   1 
ATOM   10   C CA  . LEU A 1 3   ? 26.328  15.466  33.713  1.00 73.49  ? 335 LEU A CA  1 
ATOM   11   C C   . LEU A 1 3   ? 24.912  15.993  33.506  1.00 70.87  ? 335 LEU A C   1 
ATOM   12   O O   . LEU A 1 3   ? 24.514  16.978  34.134  1.00 67.66  ? 335 LEU A O   1 
ATOM   13   C CB  . LEU A 1 3   ? 26.465  14.871  35.114  1.00 70.15  ? 335 LEU A CB  1 
ATOM   14   C CG  . LEU A 1 3   ? 25.572  13.663  35.417  1.00 76.78  ? 335 LEU A CG  1 
ATOM   15   C CD1 . LEU A 1 3   ? 26.099  12.414  34.720  1.00 62.66  ? 335 LEU A CD1 1 
ATOM   16   C CD2 . LEU A 1 3   ? 25.431  13.438  36.918  1.00 58.80  ? 335 LEU A CD2 1 
ATOM   17   N N   . CYS A 1 4   ? 24.157  15.336  32.626  1.00 71.95  ? 336 CYS A N   1 
ATOM   18   C CA  . CYS A 1 4   ? 22.791  15.768  32.363  1.00 63.10  ? 336 CYS A CA  1 
ATOM   19   C C   . CYS A 1 4   ? 21.898  15.463  33.564  1.00 52.85  ? 336 CYS A C   1 
ATOM   20   O O   . CYS A 1 4   ? 21.981  14.375  34.142  1.00 58.40  ? 336 CYS A O   1 
ATOM   21   C CB  . CYS A 1 4   ? 22.235  15.093  31.112  1.00 49.50  ? 336 CYS A CB  1 
ATOM   22   S SG  . CYS A 1 4   ? 23.075  15.570  29.581  1.00 84.79  ? 336 CYS A SG  1 
ATOM   23   N N   . PRO A 1 5   ? 21.031  16.393  33.954  1.00 43.39  ? 337 PRO A N   1 
ATOM   24   C CA  . PRO A 1 5   ? 20.232  16.248  35.178  1.00 54.99  ? 337 PRO A CA  1 
ATOM   25   C C   . PRO A 1 5   ? 19.055  15.282  35.044  1.00 45.41  ? 337 PRO A C   1 
ATOM   26   O O   . PRO A 1 5   ? 17.914  15.616  35.365  1.00 45.86  ? 337 PRO A O   1 
ATOM   27   C CB  . PRO A 1 5   ? 19.756  17.681  35.438  1.00 59.68  ? 337 PRO A CB  1 
ATOM   28   C CG  . PRO A 1 5   ? 19.673  18.288  34.084  1.00 50.40  ? 337 PRO A CG  1 
ATOM   29   C CD  . PRO A 1 5   ? 20.790  17.682  33.283  1.00 44.84  ? 337 PRO A CD  1 
ATOM   30   N N   . PHE A 1 6   ? 19.338  14.069  34.569  1.00 45.47  ? 338 PHE A N   1 
ATOM   31   C CA  . PHE A 1 6   ? 18.283  13.068  34.466  1.00 50.25  ? 338 PHE A CA  1 
ATOM   32   C C   . PHE A 1 6   ? 17.755  12.668  35.836  1.00 47.46  ? 338 PHE A C   1 
ATOM   33   O O   . PHE A 1 6   ? 16.566  12.358  35.973  1.00 52.59  ? 338 PHE A O   1 
ATOM   34   C CB  . PHE A 1 6   ? 18.793  11.839  33.718  1.00 55.80  ? 338 PHE A CB  1 
ATOM   35   C CG  . PHE A 1 6   ? 18.791  11.998  32.228  1.00 52.22  ? 338 PHE A CG  1 
ATOM   36   C CD1 . PHE A 1 6   ? 17.672  12.480  31.573  1.00 51.05  ? 338 PHE A CD1 1 
ATOM   37   C CD2 . PHE A 1 6   ? 19.911  11.676  31.485  1.00 66.12  ? 338 PHE A CD2 1 
ATOM   38   C CE1 . PHE A 1 6   ? 17.668  12.625  30.201  1.00 51.21  ? 338 PHE A CE1 1 
ATOM   39   C CE2 . PHE A 1 6   ? 19.912  11.823  30.116  1.00 65.08  ? 338 PHE A CE2 1 
ATOM   40   C CZ  . PHE A 1 6   ? 18.790  12.301  29.472  1.00 58.94  ? 338 PHE A CZ  1 
ATOM   41   N N   . GLY A 1 7   ? 18.616  12.672  36.854  1.00 56.01  ? 339 GLY A N   1 
ATOM   42   C CA  . GLY A 1 7   ? 18.182  12.261  38.179  1.00 54.94  ? 339 GLY A CA  1 
ATOM   43   C C   . GLY A 1 7   ? 17.164  13.205  38.790  1.00 49.74  ? 339 GLY A C   1 
ATOM   44   O O   . GLY A 1 7   ? 16.264  12.773  39.515  1.00 45.40  ? 339 GLY A O   1 
ATOM   45   N N   . GLU A 1 8   ? 17.296  14.505  38.515  1.00 48.80  ? 340 GLU A N   1 
ATOM   46   C CA  . GLU A 1 8   ? 16.344  15.479  39.035  1.00 40.10  ? 340 GLU A CA  1 
ATOM   47   C C   . GLU A 1 8   ? 14.935  15.237  38.516  1.00 45.33  ? 340 GLU A C   1 
ATOM   48   O O   . GLU A 1 8   ? 13.966  15.641  39.168  1.00 52.70  ? 340 GLU A O   1 
ATOM   49   C CB  . GLU A 1 8   ? 16.794  16.895  38.671  1.00 60.11  ? 340 GLU A CB  1 
ATOM   50   C CG  . GLU A 1 8   ? 18.184  17.250  39.170  1.00 68.46  ? 340 GLU A CG  1 
ATOM   51   C CD  . GLU A 1 8   ? 18.653  18.605  38.676  1.00 69.77  ? 340 GLU A CD  1 
ATOM   52   O OE1 . GLU A 1 8   ? 17.856  19.310  38.022  1.00 59.76  ? 340 GLU A OE1 1 
ATOM   53   O OE2 . GLU A 1 8   ? 19.821  18.962  38.939  1.00 80.59  ? 340 GLU A OE2 1 
ATOM   54   N N   . VAL A 1 9   ? 14.801  14.578  37.366  1.00 51.55  ? 341 VAL A N   1 
ATOM   55   C CA  . VAL A 1 9   ? 13.502  14.300  36.766  1.00 43.06  ? 341 VAL A CA  1 
ATOM   56   C C   . VAL A 1 9   ? 12.954  12.979  37.296  1.00 41.83  ? 341 VAL A C   1 
ATOM   57   O O   . VAL A 1 9   ? 11.853  12.935  37.855  1.00 41.37  ? 341 VAL A O   1 
ATOM   58   C CB  . VAL A 1 9   ? 13.602  14.279  35.230  1.00 42.30  ? 341 VAL A CB  1 
ATOM   59   C CG1 . VAL A 1 9   ? 12.293  13.811  34.614  1.00 29.79  ? 341 VAL A CG1 1 
ATOM   60   C CG2 . VAL A 1 9   ? 13.992  15.655  34.707  1.00 35.03  ? 341 VAL A CG2 1 
ATOM   61   N N   . PHE A 1 10  ? 13.718  11.896  37.125  1.00 40.14  ? 342 PHE A N   1 
ATOM   62   C CA  . PHE A 1 10  ? 13.227  10.573  37.505  1.00 41.53  ? 342 PHE A CA  1 
ATOM   63   C C   . PHE A 1 10  ? 13.096  10.436  39.017  1.00 44.15  ? 342 PHE A C   1 
ATOM   64   O O   . PHE A 1 10  ? 12.085  9.932   39.520  1.00 50.71  ? 342 PHE A O   1 
ATOM   65   C CB  . PHE A 1 10  ? 14.149  9.487   36.948  1.00 33.45  ? 342 PHE A CB  1 
ATOM   66   C CG  . PHE A 1 10  ? 14.006  9.265   35.470  1.00 38.24  ? 342 PHE A CG  1 
ATOM   67   C CD1 . PHE A 1 10  ? 14.762  9.999   34.571  1.00 44.40  ? 342 PHE A CD1 1 
ATOM   68   C CD2 . PHE A 1 10  ? 13.122  8.319   34.978  1.00 37.54  ? 342 PHE A CD2 1 
ATOM   69   C CE1 . PHE A 1 10  ? 14.636  9.797   33.209  1.00 43.49  ? 342 PHE A CE1 1 
ATOM   70   C CE2 . PHE A 1 10  ? 12.992  8.113   33.617  1.00 45.69  ? 342 PHE A CE2 1 
ATOM   71   C CZ  . PHE A 1 10  ? 13.750  8.853   32.732  1.00 39.45  ? 342 PHE A CZ  1 
ATOM   72   N N   . ASN A 1 11  ? 14.114  10.870  39.760  1.00 45.75  ? 343 ASN A N   1 
ATOM   73   C CA  . ASN A 1 11  ? 14.160  10.685  41.203  1.00 41.20  ? 343 ASN A CA  1 
ATOM   74   C C   . ASN A 1 11  ? 13.551  11.855  41.970  1.00 41.56  ? 343 ASN A C   1 
ATOM   75   O O   . ASN A 1 11  ? 13.853  12.030  43.156  1.00 43.18  ? 343 ASN A O   1 
ATOM   76   C CB  . ASN A 1 11  ? 15.606  10.446  41.653  1.00 41.65  ? 343 ASN A CB  1 
ATOM   77   C CG  . ASN A 1 11  ? 16.071  9.019   41.396  1.00 56.27  ? 343 ASN A CG  1 
ATOM   78   O OD1 . ASN A 1 11  ? 15.291  8.073   41.519  1.00 57.82  ? 343 ASN A OD1 1 
ATOM   79   N ND2 . ASN A 1 11  ? 17.345  8.855   41.038  1.00 55.74  ? 343 ASN A ND2 1 
ATOM   80   N N   . ALA A 1 12  ? 12.691  12.644  41.328  1.00 55.07  ? 344 ALA A N   1 
ATOM   81   C CA  . ALA A 1 12  ? 12.081  13.791  41.986  1.00 47.74  ? 344 ALA A CA  1 
ATOM   82   C C   . ALA A 1 12  ? 11.189  13.346  43.138  1.00 43.17  ? 344 ALA A C   1 
ATOM   83   O O   . ALA A 1 12  ? 10.506  12.321  43.060  1.00 42.45  ? 344 ALA A O   1 
ATOM   84   C CB  . ALA A 1 12  ? 11.269  14.614  40.989  1.00 36.56  ? 344 ALA A CB  1 
ATOM   85   N N   . THR A 1 13  ? 11.206  14.127  44.219  1.00 52.26  ? 345 THR A N   1 
ATOM   86   C CA  . THR A 1 13  ? 10.389  13.798  45.382  1.00 50.28  ? 345 THR A CA  1 
ATOM   87   C C   . THR A 1 13  ? 8.903   13.878  45.056  1.00 44.17  ? 345 THR A C   1 
ATOM   88   O O   . THR A 1 13  ? 8.126   13.004  45.455  1.00 41.87  ? 345 THR A O   1 
ATOM   89   C CB  . THR A 1 13  ? 10.738  14.728  46.541  1.00 50.00  ? 345 THR A CB  1 
ATOM   90   O OG1 . THR A 1 13  ? 12.151  14.686  46.775  1.00 63.57  ? 345 THR A OG1 1 
ATOM   91   C CG2 . THR A 1 13  ? 10.010  14.298  47.801  1.00 39.33  ? 345 THR A CG2 1 
ATOM   92   N N   . ARG A 1 14  ? 8.490   14.913  44.329  1.00 62.10  ? 346 ARG A N   1 
ATOM   93   C CA  . ARG A 1 14  ? 7.092   15.109  43.967  1.00 55.57  ? 346 ARG A CA  1 
ATOM   94   C C   . ARG A 1 14  ? 6.998   15.347  42.467  1.00 52.47  ? 346 ARG A C   1 
ATOM   95   O O   . ARG A 1 14  ? 7.774   16.129  41.908  1.00 43.42  ? 346 ARG A O   1 
ATOM   96   C CB  . ARG A 1 14  ? 6.479   16.285  44.743  1.00 45.79  ? 346 ARG A CB  1 
ATOM   97   C CG  . ARG A 1 14  ? 5.280   16.945  44.057  1.00 81.94  ? 346 ARG A CG  1 
ATOM   98   C CD  . ARG A 1 14  ? 5.220   18.451  44.339  1.00 91.32  ? 346 ARG A CD  1 
ATOM   99   N NE  . ARG A 1 14  ? 4.655   19.205  43.223  1.00 82.78  ? 346 ARG A NE  1 
ATOM   100  C CZ  . ARG A 1 14  ? 5.344   19.603  42.160  1.00 82.82  ? 346 ARG A CZ  1 
ATOM   101  N NH1 . ARG A 1 14  ? 6.629   19.322  42.024  1.00 81.53  ? 346 ARG A NH1 1 
ATOM   102  N NH2 . ARG A 1 14  ? 4.727   20.297  41.206  1.00 62.72  ? 346 ARG A NH2 1 
ATOM   103  N N   . PHE A 1 15  ? 6.063   14.661  41.823  1.00 54.78  ? 347 PHE A N   1 
ATOM   104  C CA  . PHE A 1 15  ? 5.779   14.852  40.410  1.00 48.07  ? 347 PHE A CA  1 
ATOM   105  C C   . PHE A 1 15  ? 4.612   15.816  40.234  1.00 49.03  ? 347 PHE A C   1 
ATOM   106  O O   . PHE A 1 15  ? 3.843   16.077  41.163  1.00 46.71  ? 347 PHE A O   1 
ATOM   107  C CB  . PHE A 1 15  ? 5.464   13.515  39.733  1.00 51.50  ? 347 PHE A CB  1 
ATOM   108  C CG  . PHE A 1 15  ? 6.668   12.830  39.153  1.00 44.75  ? 347 PHE A CG  1 
ATOM   109  C CD1 . PHE A 1 15  ? 7.768   12.544  39.942  1.00 55.27  ? 347 PHE A CD1 1 
ATOM   110  C CD2 . PHE A 1 15  ? 6.694   12.464  37.818  1.00 39.18  ? 347 PHE A CD2 1 
ATOM   111  C CE1 . PHE A 1 15  ? 8.875   11.911  39.409  1.00 42.03  ? 347 PHE A CE1 1 
ATOM   112  C CE2 . PHE A 1 15  ? 7.797   11.832  37.280  1.00 39.82  ? 347 PHE A CE2 1 
ATOM   113  C CZ  . PHE A 1 15  ? 8.889   11.555  38.076  1.00 37.28  ? 347 PHE A CZ  1 
ATOM   114  N N   . ALA A 1 16  ? 4.493   16.347  39.023  1.00 43.51  ? 348 ALA A N   1 
ATOM   115  C CA  . ALA A 1 16  ? 3.434   17.286  38.691  1.00 40.07  ? 348 ALA A CA  1 
ATOM   116  C C   . ALA A 1 16  ? 2.180   16.548  38.236  1.00 45.24  ? 348 ALA A C   1 
ATOM   117  O O   . ALA A 1 16  ? 2.224   15.387  37.823  1.00 43.08  ? 348 ALA A O   1 
ATOM   118  C CB  . ALA A 1 16  ? 3.891   18.253  37.599  1.00 36.66  ? 348 ALA A CB  1 
ATOM   119  N N   . SER A 1 17  ? 1.049   17.241  38.328  1.00 45.21  ? 349 SER A N   1 
ATOM   120  C CA  . SER A 1 17  ? -0.190  16.711  37.785  1.00 38.53  ? 349 SER A CA  1 
ATOM   121  C C   . SER A 1 17  ? -0.128  16.696  36.266  1.00 46.43  ? 349 SER A C   1 
ATOM   122  O O   . SER A 1 17  ? 0.581   17.489  35.641  1.00 49.71  ? 349 SER A O   1 
ATOM   123  C CB  . SER A 1 17  ? -1.383  17.540  38.250  1.00 41.08  ? 349 SER A CB  1 
ATOM   124  O OG  . SER A 1 17  ? -1.557  17.423  39.647  1.00 36.47  ? 349 SER A OG  1 
ATOM   125  N N   . VAL A 1 18  ? -0.891  15.782  35.671  1.00 48.20  ? 350 VAL A N   1 
ATOM   126  C CA  . VAL A 1 18  ? -0.792  15.589  34.231  1.00 38.65  ? 350 VAL A CA  1 
ATOM   127  C C   . VAL A 1 18  ? -1.245  16.836  33.472  1.00 41.78  ? 350 VAL A C   1 
ATOM   128  O O   . VAL A 1 18  ? -0.667  17.172  32.432  1.00 42.53  ? 350 VAL A O   1 
ATOM   129  C CB  . VAL A 1 18  ? -1.573  14.326  33.821  1.00 26.15  ? 350 VAL A CB  1 
ATOM   130  C CG1 . VAL A 1 18  ? -3.049  14.479  34.132  1.00 39.84  ? 350 VAL A CG1 1 
ATOM   131  C CG2 . VAL A 1 18  ? -1.344  14.012  32.360  1.00 26.66  ? 350 VAL A CG2 1 
ATOM   132  N N   . TYR A 1 19  ? -2.252  17.558  33.978  1.00 44.84  ? 351 TYR A N   1 
ATOM   133  C CA  . TYR A 1 19  ? -2.714  18.757  33.281  1.00 38.15  ? 351 TYR A CA  1 
ATOM   134  C C   . TYR A 1 19  ? -1.655  19.852  33.284  1.00 37.21  ? 351 TYR A C   1 
ATOM   135  O O   . TYR A 1 19  ? -1.630  20.692  32.378  1.00 37.54  ? 351 TYR A O   1 
ATOM   136  C CB  . TYR A 1 19  ? -4.011  19.275  33.906  1.00 32.72  ? 351 TYR A CB  1 
ATOM   137  C CG  . TYR A 1 19  ? -3.803  20.194  35.091  1.00 41.67  ? 351 TYR A CG  1 
ATOM   138  C CD1 . TYR A 1 19  ? -3.553  19.680  36.356  1.00 49.89  ? 351 TYR A CD1 1 
ATOM   139  C CD2 . TYR A 1 19  ? -3.858  21.576  34.944  1.00 37.43  ? 351 TYR A CD2 1 
ATOM   140  C CE1 . TYR A 1 19  ? -3.361  20.516  37.441  1.00 55.14  ? 351 TYR A CE1 1 
ATOM   141  C CE2 . TYR A 1 19  ? -3.666  22.417  36.022  1.00 39.44  ? 351 TYR A CE2 1 
ATOM   142  C CZ  . TYR A 1 19  ? -3.419  21.883  37.267  1.00 43.19  ? 351 TYR A CZ  1 
ATOM   143  O OH  . TYR A 1 19  ? -3.229  22.724  38.339  1.00 42.73  ? 351 TYR A OH  1 
ATOM   144  N N   . ALA A 1 20  ? -0.777  19.859  34.283  1.00 41.97  ? 352 ALA A N   1 
ATOM   145  C CA  . ALA A 1 20  ? 0.284   20.853  34.360  1.00 34.10  ? 352 ALA A CA  1 
ATOM   146  C C   . ALA A 1 20  ? 1.639   20.160  34.310  1.00 42.13  ? 352 ALA A C   1 
ATOM   147  O O   . ALA A 1 20  ? 2.506   20.422  35.149  1.00 48.27  ? 352 ALA A O   1 
ATOM   148  C CB  . ALA A 1 20  ? 0.146   21.692  35.631  1.00 33.19  ? 352 ALA A CB  1 
ATOM   149  N N   . TRP A 1 21  ? 1.815   19.259  33.345  1.00 37.87  ? 353 TRP A N   1 
ATOM   150  C CA  . TRP A 1 21  ? 3.027   18.452  33.266  1.00 35.33  ? 353 TRP A CA  1 
ATOM   151  C C   . TRP A 1 21  ? 4.266   19.330  33.139  1.00 44.67  ? 353 TRP A C   1 
ATOM   152  O O   . TRP A 1 21  ? 4.272   20.323  32.407  1.00 50.06  ? 353 TRP A O   1 
ATOM   153  C CB  . TRP A 1 21  ? 2.937   17.483  32.082  1.00 34.14  ? 353 TRP A CB  1 
ATOM   154  C CG  . TRP A 1 21  ? 2.503   18.117  30.773  1.00 42.13  ? 353 TRP A CG  1 
ATOM   155  C CD1 . TRP A 1 21  ? 1.222   18.385  30.374  1.00 37.58  ? 353 TRP A CD1 1 
ATOM   156  C CD2 . TRP A 1 21  ? 3.350   18.534  29.690  1.00 39.01  ? 353 TRP A CD2 1 
ATOM   157  N NE1 . TRP A 1 21  ? 1.221   18.951  29.121  1.00 25.18  ? 353 TRP A NE1 1 
ATOM   158  C CE2 . TRP A 1 21  ? 2.514   19.053  28.679  1.00 29.47  ? 353 TRP A CE2 1 
ATOM   159  C CE3 . TRP A 1 21  ? 4.733   18.524  29.481  1.00 37.70  ? 353 TRP A CE3 1 
ATOM   160  C CZ2 . TRP A 1 21  ? 3.016   19.557  27.479  1.00 34.16  ? 353 TRP A CZ2 1 
ATOM   161  C CZ3 . TRP A 1 21  ? 5.230   19.025  28.287  1.00 33.17  ? 353 TRP A CZ3 1 
ATOM   162  C CH2 . TRP A 1 21  ? 4.372   19.534  27.303  1.00 35.45  ? 353 TRP A CH2 1 
ATOM   163  N N   . ASN A 1 22  ? 5.320   18.968  33.869  1.00 41.78  ? 354 ASN A N   1 
ATOM   164  C CA  . ASN A 1 22  ? 6.574   19.703  33.778  1.00 38.67  ? 354 ASN A CA  1 
ATOM   165  C C   . ASN A 1 22  ? 7.418   19.181  32.625  1.00 31.44  ? 354 ASN A C   1 
ATOM   166  O O   . ASN A 1 22  ? 7.381   17.996  32.288  1.00 31.00  ? 354 ASN A O   1 
ATOM   167  C CB  . ASN A 1 22  ? 7.370   19.603  35.081  1.00 24.13  ? 354 ASN A CB  1 
ATOM   168  C CG  . ASN A 1 22  ? 6.676   20.283  36.239  1.00 50.68  ? 354 ASN A CG  1 
ATOM   169  O OD1 . ASN A 1 22  ? 6.854   19.900  37.394  1.00 49.31  ? 354 ASN A OD1 1 
ATOM   170  N ND2 . ASN A 1 22  ? 5.869   21.294  35.935  1.00 65.27  ? 354 ASN A ND2 1 
ATOM   171  N N   . ARG A 1 23  ? 8.180   20.084  32.016  1.00 38.24  ? 355 ARG A N   1 
ATOM   172  C CA  . ARG A 1 23  ? 9.134   19.733  30.974  1.00 34.32  ? 355 ARG A CA  1 
ATOM   173  C C   . ARG A 1 23  ? 10.515  20.232  31.371  1.00 39.61  ? 355 ARG A C   1 
ATOM   174  O O   . ARG A 1 23  ? 10.687  21.415  31.683  1.00 50.98  ? 355 ARG A O   1 
ATOM   175  C CB  . ARG A 1 23  ? 8.727   20.321  29.621  1.00 42.47  ? 355 ARG A CB  1 
ATOM   176  C CG  . ARG A 1 23  ? 9.857   20.342  28.605  1.00 37.94  ? 355 ARG A CG  1 
ATOM   177  C CD  . ARG A 1 23  ? 9.346   20.627  27.211  1.00 30.68  ? 355 ARG A CD  1 
ATOM   178  N NE  . ARG A 1 23  ? 8.666   19.469  26.648  1.00 34.01  ? 355 ARG A NE  1 
ATOM   179  C CZ  . ARG A 1 23  ? 8.163   19.418  25.423  1.00 49.52  ? 355 ARG A CZ  1 
ATOM   180  N NH1 . ARG A 1 23  ? 8.262   20.444  24.592  1.00 36.67  ? 355 ARG A NH1 1 
ATOM   181  N NH2 . ARG A 1 23  ? 7.544   18.310  25.023  1.00 42.64  ? 355 ARG A NH2 1 
ATOM   182  N N   . LYS A 1 24  ? 11.493  19.331  31.355  1.00 39.02  ? 356 LYS A N   1 
ATOM   183  C CA  . LYS A 1 24  ? 12.872  19.651  31.693  1.00 39.22  ? 356 LYS A CA  1 
ATOM   184  C C   . LYS A 1 24  ? 13.680  19.762  30.407  1.00 40.32  ? 356 LYS A C   1 
ATOM   185  O O   . LYS A 1 24  ? 13.728  18.813  29.616  1.00 40.32  ? 356 LYS A O   1 
ATOM   186  C CB  . LYS A 1 24  ? 13.463  18.584  32.615  1.00 45.41  ? 356 LYS A CB  1 
ATOM   187  C CG  . LYS A 1 24  ? 14.924  18.795  32.998  1.00 52.10  ? 356 LYS A CG  1 
ATOM   188  C CD  . LYS A 1 24  ? 15.121  20.052  33.827  1.00 47.68  ? 356 LYS A CD  1 
ATOM   189  C CE  . LYS A 1 24  ? 16.554  20.156  34.319  1.00 54.44  ? 356 LYS A CE  1 
ATOM   190  N NZ  . LYS A 1 24  ? 17.148  21.487  34.022  1.00 54.28  ? 356 LYS A NZ  1 
ATOM   191  N N   . ARG A 1 25  ? 14.305  20.916  30.196  1.00 51.80  ? 357 ARG A N   1 
ATOM   192  C CA  . ARG A 1 25  ? 15.172  21.121  29.044  1.00 51.33  ? 357 ARG A CA  1 
ATOM   193  C C   . ARG A 1 25  ? 16.588  20.701  29.414  1.00 52.54  ? 357 ARG A C   1 
ATOM   194  O O   . ARG A 1 25  ? 17.159  21.207  30.386  1.00 62.71  ? 357 ARG A O   1 
ATOM   195  C CB  . ARG A 1 25  ? 15.143  22.577  28.584  1.00 60.41  ? 357 ARG A CB  1 
ATOM   196  C CG  . ARG A 1 25  ? 15.883  22.821  27.281  1.00 51.39  ? 357 ARG A CG  1 
ATOM   197  C CD  . ARG A 1 25  ? 15.616  24.217  26.754  1.00 52.62  ? 357 ARG A CD  1 
ATOM   198  N NE  . ARG A 1 25  ? 15.769  24.285  25.307  1.00 60.67  ? 357 ARG A NE  1 
ATOM   199  C CZ  . ARG A 1 25  ? 16.861  24.709  24.687  1.00 71.87  ? 357 ARG A CZ  1 
ATOM   200  N NH1 . ARG A 1 25  ? 17.922  25.123  25.361  1.00 49.51  ? 357 ARG A NH1 1 
ATOM   201  N NH2 . ARG A 1 25  ? 16.887  24.722  23.357  1.00 79.84  ? 357 ARG A NH2 1 
ATOM   202  N N   . ILE A 1 26  ? 17.146  19.774  28.643  1.00 55.43  ? 358 ILE A N   1 
ATOM   203  C CA  . ILE A 1 26  ? 18.472  19.223  28.889  1.00 54.27  ? 358 ILE A CA  1 
ATOM   204  C C   . ILE A 1 26  ? 19.372  19.650  27.737  1.00 62.71  ? 358 ILE A C   1 
ATOM   205  O O   . ILE A 1 26  ? 19.110  19.312  26.576  1.00 57.63  ? 358 ILE A O   1 
ATOM   206  C CB  . ILE A 1 26  ? 18.421  17.695  29.036  1.00 48.48  ? 358 ILE A CB  1 
ATOM   207  C CG1 . ILE A 1 26  ? 17.853  17.325  30.404  1.00 48.99  ? 358 ILE A CG1 1 
ATOM   208  C CG2 . ILE A 1 26  ? 19.789  17.080  28.852  1.00 64.74  ? 358 ILE A CG2 1 
ATOM   209  C CD1 . ILE A 1 26  ? 17.227  15.969  30.437  1.00 50.83  ? 358 ILE A CD1 1 
ATOM   210  N N   . SER A 1 27  ? 20.425  20.403  28.057  1.00 67.62  ? 359 SER A N   1 
ATOM   211  C CA  . SER A 1 27  ? 21.326  20.935  27.046  1.00 65.43  ? 359 SER A CA  1 
ATOM   212  C C   . SER A 1 27  ? 22.716  21.103  27.640  1.00 71.34  ? 359 SER A C   1 
ATOM   213  O O   . SER A 1 27  ? 22.871  21.323  28.845  1.00 59.28  ? 359 SER A O   1 
ATOM   214  C CB  . SER A 1 27  ? 20.823  22.275  26.492  1.00 61.15  ? 359 SER A CB  1 
ATOM   215  O OG  . SER A 1 27  ? 20.588  23.207  27.533  1.00 68.61  ? 359 SER A OG  1 
ATOM   216  N N   . ASN A 1 28  ? 23.726  20.994  26.772  1.00 76.46  ? 360 ASN A N   1 
ATOM   217  C CA  . ASN A 1 28  ? 25.125  21.242  27.123  1.00 77.14  ? 360 ASN A CA  1 
ATOM   218  C C   . ASN A 1 28  ? 25.580  20.348  28.278  1.00 69.85  ? 360 ASN A C   1 
ATOM   219  O O   . ASN A 1 28  ? 26.015  20.816  29.332  1.00 81.46  ? 360 ASN A O   1 
ATOM   220  C CB  . ASN A 1 28  ? 25.348  22.721  27.454  1.00 87.15  ? 360 ASN A CB  1 
ATOM   221  C CG  . ASN A 1 28  ? 25.275  23.606  26.230  1.00 94.73  ? 360 ASN A CG  1 
ATOM   222  O OD1 . ASN A 1 28  ? 25.908  23.329  25.211  1.00 98.62  ? 360 ASN A OD1 1 
ATOM   223  N ND2 . ASN A 1 28  ? 24.495  24.677  26.320  1.00 87.64  ? 360 ASN A ND2 1 
ATOM   224  N N   . CYS A 1 29  ? 25.475  19.041  28.055  1.00 75.37  ? 361 CYS A N   1 
ATOM   225  C CA  . CYS A 1 29  ? 25.900  18.067  29.050  1.00 77.06  ? 361 CYS A CA  1 
ATOM   226  C C   . CYS A 1 29  ? 26.100  16.720  28.374  1.00 73.85  ? 361 CYS A C   1 
ATOM   227  O O   . CYS A 1 29  ? 25.636  16.489  27.255  1.00 67.43  ? 361 CYS A O   1 
ATOM   228  C CB  . CYS A 1 29  ? 24.887  17.948  30.195  1.00 69.50  ? 361 CYS A CB  1 
ATOM   229  S SG  . CYS A 1 29  ? 23.195  17.598  29.655  1.00 74.57  ? 361 CYS A SG  1 
ATOM   230  N N   . VAL A 1 30  ? 26.803  15.835  29.076  1.00 78.77  ? 362 VAL A N   1 
ATOM   231  C CA  . VAL A 1 30  ? 27.000  14.456  28.648  1.00 84.41  ? 362 VAL A CA  1 
ATOM   232  C C   . VAL A 1 30  ? 25.980  13.589  29.369  1.00 77.99  ? 362 VAL A C   1 
ATOM   233  O O   . VAL A 1 30  ? 25.879  13.629  30.602  1.00 75.38  ? 362 VAL A O   1 
ATOM   234  C CB  . VAL A 1 30  ? 28.432  13.977  28.939  1.00 78.69  ? 362 VAL A CB  1 
ATOM   235  C CG1 . VAL A 1 30  ? 28.623  12.551  28.441  1.00 68.78  ? 362 VAL A CG1 1 
ATOM   236  C CG2 . VAL A 1 30  ? 29.444  14.922  28.306  1.00 84.10  ? 362 VAL A CG2 1 
ATOM   237  N N   . ALA A 1 31  ? 25.225  12.807  28.606  1.00 79.71  ? 363 ALA A N   1 
ATOM   238  C CA  . ALA A 1 31  ? 24.093  12.055  29.130  1.00 82.89  ? 363 ALA A CA  1 
ATOM   239  C C   . ALA A 1 31  ? 24.431  10.573  29.149  1.00 77.45  ? 363 ALA A C   1 
ATOM   240  O O   . ALA A 1 31  ? 24.715  9.982   28.102  1.00 89.45  ? 363 ALA A O   1 
ATOM   241  C CB  . ALA A 1 31  ? 22.841  12.308  28.292  1.00 78.17  ? 363 ALA A CB  1 
ATOM   242  N N   . ASP A 1 32  ? 24.385  9.975   30.334  1.00 63.32  ? 364 ASP A N   1 
ATOM   243  C CA  . ASP A 1 32  ? 24.536  8.537   30.490  1.00 73.21  ? 364 ASP A CA  1 
ATOM   244  C C   . ASP A 1 32  ? 23.155  7.915   30.643  1.00 85.43  ? 364 ASP A C   1 
ATOM   245  O O   . ASP A 1 32  ? 22.416  8.254   31.573  1.00 90.07  ? 364 ASP A O   1 
ATOM   246  C CB  . ASP A 1 32  ? 25.406  8.199   31.696  1.00 76.75  ? 364 ASP A CB  1 
ATOM   247  C CG  . ASP A 1 32  ? 25.351  6.731   32.047  1.00 87.07  ? 364 ASP A CG  1 
ATOM   248  O OD1 . ASP A 1 32  ? 25.968  5.923   31.321  1.00 77.52  ? 364 ASP A OD1 1 
ATOM   249  O OD2 . ASP A 1 32  ? 24.674  6.384   33.038  1.00 86.68  ? 364 ASP A OD2 1 
ATOM   250  N N   . TYR A 1 33  ? 22.814  7.003   29.736  1.00 71.40  ? 365 TYR A N   1 
ATOM   251  C CA  . TYR A 1 33  ? 21.499  6.385   29.728  1.00 60.04  ? 365 TYR A CA  1 
ATOM   252  C C   . TYR A 1 33  ? 21.499  4.965   30.272  1.00 64.83  ? 365 TYR A C   1 
ATOM   253  O O   . TYR A 1 33  ? 20.420  4.394   30.460  1.00 62.29  ? 365 TYR A O   1 
ATOM   254  C CB  . TYR A 1 33  ? 20.928  6.383   28.307  1.00 59.60  ? 365 TYR A CB  1 
ATOM   255  C CG  . TYR A 1 33  ? 20.839  7.756   27.682  1.00 70.68  ? 365 TYR A CG  1 
ATOM   256  C CD1 . TYR A 1 33  ? 21.906  8.289   26.970  1.00 63.62  ? 365 TYR A CD1 1 
ATOM   257  C CD2 . TYR A 1 33  ? 19.687  8.520   27.805  1.00 76.00  ? 365 TYR A CD2 1 
ATOM   258  C CE1 . TYR A 1 33  ? 21.825  9.541   26.392  1.00 69.77  ? 365 TYR A CE1 1 
ATOM   259  C CE2 . TYR A 1 33  ? 19.597  9.774   27.231  1.00 72.39  ? 365 TYR A CE2 1 
ATOM   260  C CZ  . TYR A 1 33  ? 20.669  10.280  26.527  1.00 70.74  ? 365 TYR A CZ  1 
ATOM   261  O OH  . TYR A 1 33  ? 20.582  11.530  25.958  1.00 69.60  ? 365 TYR A OH  1 
ATOM   262  N N   . SER A 1 34  ? 22.674  4.385   30.537  1.00 71.51  ? 366 SER A N   1 
ATOM   263  C CA  . SER A 1 34  ? 22.720  3.029   31.076  1.00 62.83  ? 366 SER A CA  1 
ATOM   264  C C   . SER A 1 34  ? 22.008  2.939   32.420  1.00 67.24  ? 366 SER A C   1 
ATOM   265  O O   . SER A 1 34  ? 21.493  1.874   32.777  1.00 54.17  ? 366 SER A O   1 
ATOM   266  C CB  . SER A 1 34  ? 24.171  2.562   31.201  1.00 59.03  ? 366 SER A CB  1 
ATOM   267  O OG  . SER A 1 34  ? 24.916  3.425   32.043  1.00 87.27  ? 366 SER A OG  1 
ATOM   268  N N   . VAL A 1 35  ? 21.951  4.047   33.165  1.00 76.18  ? 367 VAL A N   1 
ATOM   269  C CA  . VAL A 1 35  ? 21.204  4.076   34.419  1.00 65.39  ? 367 VAL A CA  1 
ATOM   270  C C   . VAL A 1 35  ? 19.728  3.790   34.171  1.00 60.93  ? 367 VAL A C   1 
ATOM   271  O O   . VAL A 1 35  ? 19.032  3.260   35.046  1.00 64.37  ? 367 VAL A O   1 
ATOM   272  C CB  . VAL A 1 35  ? 21.418  5.433   35.128  1.00 55.00  ? 367 VAL A CB  1 
ATOM   273  C CG1 . VAL A 1 35  ? 20.966  6.584   34.239  1.00 63.27  ? 367 VAL A CG1 1 
ATOM   274  C CG2 . VAL A 1 35  ? 20.702  5.474   36.473  1.00 47.33  ? 367 VAL A CG2 1 
ATOM   275  N N   . LEU A 1 36  ? 19.233  4.102   32.973  1.00 55.18  ? 368 LEU A N   1 
ATOM   276  C CA  . LEU A 1 36  ? 17.815  3.952   32.666  1.00 53.56  ? 368 LEU A CA  1 
ATOM   277  C C   . LEU A 1 36  ? 17.487  2.571   32.096  1.00 60.30  ? 368 LEU A C   1 
ATOM   278  O O   . LEU A 1 36  ? 16.689  1.831   32.679  1.00 61.69  ? 368 LEU A O   1 
ATOM   279  C CB  . LEU A 1 36  ? 17.375  5.058   31.700  1.00 52.21  ? 368 LEU A CB  1 
ATOM   280  C CG  . LEU A 1 36  ? 17.657  6.486   32.175  1.00 54.20  ? 368 LEU A CG  1 
ATOM   281  C CD1 . LEU A 1 36  ? 17.115  7.505   31.188  1.00 49.42  ? 368 LEU A CD1 1 
ATOM   282  C CD2 . LEU A 1 36  ? 17.068  6.712   33.556  1.00 46.74  ? 368 LEU A CD2 1 
ATOM   283  N N   . TYR A 1 37  ? 18.098  2.202   30.964  1.00 57.99  ? 369 TYR A N   1 
ATOM   284  C CA  . TYR A 1 37  ? 17.690  0.972   30.289  1.00 53.09  ? 369 TYR A CA  1 
ATOM   285  C C   . TYR A 1 37  ? 18.213  -0.291  30.965  1.00 61.75  ? 369 TYR A C   1 
ATOM   286  O O   . TYR A 1 37  ? 17.674  -1.375  30.715  1.00 58.66  ? 369 TYR A O   1 
ATOM   287  C CB  . TYR A 1 37  ? 18.111  0.988   28.812  1.00 55.39  ? 369 TYR A CB  1 
ATOM   288  C CG  . TYR A 1 37  ? 19.596  1.107   28.526  1.00 59.28  ? 369 TYR A CG  1 
ATOM   289  C CD1 . TYR A 1 37  ? 20.434  -0.002  28.589  1.00 63.81  ? 369 TYR A CD1 1 
ATOM   290  C CD2 . TYR A 1 37  ? 20.150  2.321   28.141  1.00 63.08  ? 369 TYR A CD2 1 
ATOM   291  C CE1 . TYR A 1 37  ? 21.787  0.105   28.309  1.00 65.10  ? 369 TYR A CE1 1 
ATOM   292  C CE2 . TYR A 1 37  ? 21.499  2.437   27.858  1.00 65.72  ? 369 TYR A CE2 1 
ATOM   293  C CZ  . TYR A 1 37  ? 22.312  1.329   27.944  1.00 67.85  ? 369 TYR A CZ  1 
ATOM   294  O OH  . TYR A 1 37  ? 23.653  1.452   27.661  1.00 74.10  ? 369 TYR A OH  1 
ATOM   295  N N   . ASN A 1 38  ? 19.232  -0.187  31.814  1.00 63.89  ? 370 ASN A N   1 
ATOM   296  C CA  . ASN A 1 38  ? 19.670  -1.326  32.608  1.00 62.54  ? 370 ASN A CA  1 
ATOM   297  C C   . ASN A 1 38  ? 18.904  -1.456  33.916  1.00 60.59  ? 370 ASN A C   1 
ATOM   298  O O   . ASN A 1 38  ? 19.141  -2.409  34.666  1.00 65.09  ? 370 ASN A O   1 
ATOM   299  C CB  . ASN A 1 38  ? 21.172  -1.234  32.900  1.00 68.21  ? 370 ASN A CB  1 
ATOM   300  C CG  . ASN A 1 38  ? 22.018  -1.553  31.689  1.00 65.71  ? 370 ASN A CG  1 
ATOM   301  O OD1 . ASN A 1 38  ? 21.607  -2.316  30.814  1.00 66.49  ? 370 ASN A OD1 1 
ATOM   302  N ND2 . ASN A 1 38  ? 23.211  -0.973  31.630  1.00 69.34  ? 370 ASN A ND2 1 
ATOM   303  N N   . SER A 1 39  ? 18.002  -0.525  34.209  1.00 52.45  ? 371 SER A N   1 
ATOM   304  C CA  . SER A 1 39  ? 17.232  -0.600  35.437  1.00 54.46  ? 371 SER A CA  1 
ATOM   305  C C   . SER A 1 39  ? 16.168  -1.689  35.343  1.00 58.18  ? 371 SER A C   1 
ATOM   306  O O   . SER A 1 39  ? 15.802  -2.156  34.260  1.00 55.80  ? 371 SER A O   1 
ATOM   307  C CB  . SER A 1 39  ? 16.575  0.745   35.746  1.00 58.60  ? 371 SER A CB  1 
ATOM   308  O OG  . SER A 1 39  ? 15.557  0.593   36.721  1.00 58.79  ? 371 SER A OG  1 
ATOM   309  N N   . ALA A 1 40  ? 15.672  -2.094  36.513  1.00 59.62  ? 372 ALA A N   1 
ATOM   310  C CA  . ALA A 1 40  ? 14.600  -3.075  36.621  1.00 56.29  ? 372 ALA A CA  1 
ATOM   311  C C   . ALA A 1 40  ? 13.396  -2.517  37.370  1.00 55.39  ? 372 ALA A C   1 
ATOM   312  O O   . ALA A 1 40  ? 12.530  -3.282  37.806  1.00 64.14  ? 372 ALA A O   1 
ATOM   313  C CB  . ALA A 1 40  ? 15.108  -4.347  37.302  1.00 45.15  ? 372 ALA A CB  1 
ATOM   314  N N   . SER A 1 41  ? 13.323  -1.197  37.527  1.00 48.13  ? 373 SER A N   1 
ATOM   315  C CA  . SER A 1 41  ? 12.243  -0.565  38.271  1.00 62.57  ? 373 SER A CA  1 
ATOM   316  C C   . SER A 1 41  ? 11.071  -0.141  37.393  1.00 56.92  ? 373 SER A C   1 
ATOM   317  O O   . SER A 1 41  ? 10.007  0.192   37.928  1.00 39.70  ? 373 SER A O   1 
ATOM   318  C CB  . SER A 1 41  ? 12.779  0.655   39.032  1.00 63.44  ? 373 SER A CB  1 
ATOM   319  O OG  . SER A 1 41  ? 11.730  1.391   39.637  1.00 70.62  ? 373 SER A OG  1 
ATOM   320  N N   . PHE A 1 42  ? 11.230  -0.160  36.072  1.00 56.08  ? 374 PHE A N   1 
ATOM   321  C CA  . PHE A 1 42  ? 10.219  0.351   35.155  1.00 36.38  ? 374 PHE A CA  1 
ATOM   322  C C   . PHE A 1 42  ? 9.232   -0.741  34.762  1.00 44.64  ? 374 PHE A C   1 
ATOM   323  O O   . PHE A 1 42  ? 9.625   -1.866  34.440  1.00 54.45  ? 374 PHE A O   1 
ATOM   324  C CB  . PHE A 1 42  ? 10.879  0.921   33.898  1.00 30.32  ? 374 PHE A CB  1 
ATOM   325  C CG  . PHE A 1 42  ? 11.853  2.032   34.172  1.00 44.23  ? 374 PHE A CG  1 
ATOM   326  C CD1 . PHE A 1 42  ? 11.577  2.993   35.130  1.00 42.60  ? 374 PHE A CD1 1 
ATOM   327  C CD2 . PHE A 1 42  ? 13.047  2.113   33.474  1.00 42.87  ? 374 PHE A CD2 1 
ATOM   328  C CE1 . PHE A 1 42  ? 12.469  4.015   35.382  1.00 42.01  ? 374 PHE A CE1 1 
ATOM   329  C CE2 . PHE A 1 42  ? 13.945  3.134   33.724  1.00 39.99  ? 374 PHE A CE2 1 
ATOM   330  C CZ  . PHE A 1 42  ? 13.655  4.085   34.678  1.00 42.50  ? 374 PHE A CZ  1 
ATOM   331  N N   . SER A 1 43  ? 7.943   -0.398  34.780  1.00 36.81  ? 375 SER A N   1 
ATOM   332  C CA  . SER A 1 43  ? 6.919   -1.294  34.258  1.00 34.16  ? 375 SER A CA  1 
ATOM   333  C C   . SER A 1 43  ? 6.654   -1.089  32.773  1.00 42.58  ? 375 SER A C   1 
ATOM   334  O O   . SER A 1 43  ? 6.051   -1.963  32.139  1.00 43.71  ? 375 SER A O   1 
ATOM   335  C CB  . SER A 1 43  ? 5.608   -1.114  35.029  1.00 34.43  ? 375 SER A CB  1 
ATOM   336  O OG  . SER A 1 43  ? 5.111   0.203   34.872  1.00 48.76  ? 375 SER A OG  1 
ATOM   337  N N   . THR A 1 44  ? 7.080   0.041   32.210  1.00 41.99  ? 376 THR A N   1 
ATOM   338  C CA  . THR A 1 44  ? 6.894   0.331   30.793  1.00 32.89  ? 376 THR A CA  1 
ATOM   339  C C   . THR A 1 44  ? 8.072   1.168   30.317  1.00 35.24  ? 376 THR A C   1 
ATOM   340  O O   . THR A 1 44  ? 8.418   2.169   30.950  1.00 38.15  ? 376 THR A O   1 
ATOM   341  C CB  . THR A 1 44  ? 5.577   1.079   30.535  1.00 40.57  ? 376 THR A CB  1 
ATOM   342  O OG1 . THR A 1 44  ? 4.567   0.609   31.437  1.00 58.54  ? 376 THR A OG1 1 
ATOM   343  C CG2 . THR A 1 44  ? 5.105   0.853   29.103  1.00 42.74  ? 376 THR A CG2 1 
ATOM   344  N N   . PHE A 1 45  ? 8.690   0.746   29.217  1.00 36.20  ? 377 PHE A N   1 
ATOM   345  C CA  . PHE A 1 45  ? 9.813   1.457   28.612  1.00 28.32  ? 377 PHE A CA  1 
ATOM   346  C C   . PHE A 1 45  ? 9.637   1.493   27.098  1.00 37.12  ? 377 PHE A C   1 
ATOM   347  O O   . PHE A 1 45  ? 10.530  1.129   26.331  1.00 33.36  ? 377 PHE A O   1 
ATOM   348  C CB  . PHE A 1 45  ? 11.137  0.812   29.005  1.00 35.03  ? 377 PHE A CB  1 
ATOM   349  C CG  . PHE A 1 45  ? 12.303  1.759   29.005  1.00 39.19  ? 377 PHE A CG  1 
ATOM   350  C CD1 . PHE A 1 45  ? 12.467  2.698   27.999  1.00 40.26  ? 377 PHE A CD1 1 
ATOM   351  C CD2 . PHE A 1 45  ? 13.236  1.707   30.022  1.00 41.88  ? 377 PHE A CD2 1 
ATOM   352  C CE1 . PHE A 1 45  ? 13.542  3.559   28.008  1.00 30.52  ? 377 PHE A CE1 1 
ATOM   353  C CE2 . PHE A 1 45  ? 14.309  2.564   30.037  1.00 42.49  ? 377 PHE A CE2 1 
ATOM   354  C CZ  . PHE A 1 45  ? 14.464  3.492   29.029  1.00 37.74  ? 377 PHE A CZ  1 
ATOM   355  N N   . LYS A 1 46  ? 8.452   1.903   26.656  1.00 39.63  ? 378 LYS A N   1 
ATOM   356  C CA  . LYS A 1 46  ? 8.152   1.947   25.231  1.00 36.15  ? 378 LYS A CA  1 
ATOM   357  C C   . LYS A 1 46  ? 8.933   3.061   24.548  1.00 45.93  ? 378 LYS A C   1 
ATOM   358  O O   . LYS A 1 46  ? 8.843   4.228   24.942  1.00 46.28  ? 378 LYS A O   1 
ATOM   359  C CB  . LYS A 1 46  ? 6.658   2.156   25.013  1.00 37.33  ? 378 LYS A CB  1 
ATOM   360  C CG  . LYS A 1 46  ? 5.855   0.882   24.997  1.00 35.63  ? 378 LYS A CG  1 
ATOM   361  C CD  . LYS A 1 46  ? 4.417   1.156   24.629  1.00 39.05  ? 378 LYS A CD  1 
ATOM   362  C CE  . LYS A 1 46  ? 3.759   -0.094  24.101  1.00 39.00  ? 378 LYS A CE  1 
ATOM   363  N NZ  . LYS A 1 46  ? 2.323   0.146   23.806  1.00 43.58  ? 378 LYS A NZ  1 
ATOM   364  N N   . CYS A 1 47  ? 9.678   2.704   23.507  1.00 41.33  ? 379 CYS A N   1 
ATOM   365  C CA  . CYS A 1 47  ? 10.456  3.659   22.732  1.00 40.74  ? 379 CYS A CA  1 
ATOM   366  C C   . CYS A 1 47  ? 9.992   3.619   21.287  1.00 41.17  ? 379 CYS A C   1 
ATOM   367  O O   . CYS A 1 47  ? 9.811   2.537   20.718  1.00 45.22  ? 379 CYS A O   1 
ATOM   368  C CB  . CYS A 1 47  ? 11.952  3.356   22.809  1.00 29.89  ? 379 CYS A CB  1 
ATOM   369  S SG  . CYS A 1 47  ? 12.674  3.605   24.439  1.00 54.19  ? 379 CYS A SG  1 
ATOM   370  N N   . TYR A 1 48  ? 9.810   4.792   20.695  1.00 39.57  ? 380 TYR A N   1 
ATOM   371  C CA  . TYR A 1 48  ? 9.304   4.906   19.334  1.00 36.78  ? 380 TYR A CA  1 
ATOM   372  C C   . TYR A 1 48  ? 10.359  5.593   18.480  1.00 37.86  ? 380 TYR A C   1 
ATOM   373  O O   . TYR A 1 48  ? 10.672  6.769   18.695  1.00 53.23  ? 380 TYR A O   1 
ATOM   374  C CB  . TYR A 1 48  ? 7.987   5.677   19.306  1.00 29.33  ? 380 TYR A CB  1 
ATOM   375  C CG  . TYR A 1 48  ? 6.886   5.056   20.138  1.00 26.69  ? 380 TYR A CG  1 
ATOM   376  C CD1 . TYR A 1 48  ? 6.824   5.253   21.513  1.00 29.54  ? 380 TYR A CD1 1 
ATOM   377  C CD2 . TYR A 1 48  ? 5.894   4.292   19.543  1.00 27.54  ? 380 TYR A CD2 1 
ATOM   378  C CE1 . TYR A 1 48  ? 5.808   4.691   22.271  1.00 36.60  ? 380 TYR A CE1 1 
ATOM   379  C CE2 . TYR A 1 48  ? 4.878   3.728   20.289  1.00 39.82  ? 380 TYR A CE2 1 
ATOM   380  C CZ  . TYR A 1 48  ? 4.837   3.930   21.650  1.00 41.81  ? 380 TYR A CZ  1 
ATOM   381  O OH  . TYR A 1 48  ? 3.816   3.363   22.378  1.00 44.62  ? 380 TYR A OH  1 
ATOM   382  N N   . GLY A 1 49  ? 10.904  4.860   17.512  1.00 34.83  ? 381 GLY A N   1 
ATOM   383  C CA  . GLY A 1 49  ? 11.790  5.437   16.529  1.00 42.88  ? 381 GLY A CA  1 
ATOM   384  C C   . GLY A 1 49  ? 13.225  5.609   16.968  1.00 49.88  ? 381 GLY A C   1 
ATOM   385  O O   . GLY A 1 49  ? 14.069  5.968   16.136  1.00 58.61  ? 381 GLY A O   1 
ATOM   386  N N   . VAL A 1 50  ? 13.537  5.376   18.241  1.00 48.12  ? 382 VAL A N   1 
ATOM   387  C CA  . VAL A 1 50  ? 14.903  5.472   18.731  1.00 46.49  ? 382 VAL A CA  1 
ATOM   388  C C   . VAL A 1 50  ? 15.220  4.224   19.539  1.00 44.97  ? 382 VAL A C   1 
ATOM   389  O O   . VAL A 1 50  ? 14.334  3.556   20.076  1.00 51.91  ? 382 VAL A O   1 
ATOM   390  C CB  . VAL A 1 50  ? 15.138  6.737   19.582  1.00 37.89  ? 382 VAL A CB  1 
ATOM   391  C CG1 . VAL A 1 50  ? 14.961  7.984   18.731  1.00 57.07  ? 382 VAL A CG1 1 
ATOM   392  C CG2 . VAL A 1 50  ? 14.195  6.756   20.773  1.00 39.68  ? 382 VAL A CG2 1 
ATOM   393  N N   . SER A 1 51  ? 16.508  3.915   19.618  1.00 45.90  ? 383 SER A N   1 
ATOM   394  C CA  . SER A 1 51  ? 16.970  2.735   20.335  1.00 51.83  ? 383 SER A CA  1 
ATOM   395  C C   . SER A 1 51  ? 17.648  3.153   21.633  1.00 58.50  ? 383 SER A C   1 
ATOM   396  O O   . SER A 1 51  ? 18.766  3.693   21.593  1.00 58.69  ? 383 SER A O   1 
ATOM   397  C CB  . SER A 1 51  ? 17.930  1.927   19.463  1.00 49.65  ? 383 SER A CB  1 
ATOM   398  O OG  . SER A 1 51  ? 18.294  0.716   20.097  1.00 62.28  ? 383 SER A OG  1 
ATOM   399  N N   . PRO A 1 52  ? 17.021  2.937   22.793  1.00 51.84  ? 384 PRO A N   1 
ATOM   400  C CA  . PRO A 1 52  ? 17.646  3.365   24.058  1.00 56.06  ? 384 PRO A CA  1 
ATOM   401  C C   . PRO A 1 52  ? 18.982  2.701   24.337  1.00 62.50  ? 384 PRO A C   1 
ATOM   402  O O   . PRO A 1 52  ? 19.863  3.332   24.937  1.00 57.28  ? 384 PRO A O   1 
ATOM   403  C CB  . PRO A 1 52  ? 16.594  2.986   25.112  1.00 47.64  ? 384 PRO A CB  1 
ATOM   404  C CG  . PRO A 1 52  ? 15.782  1.907   24.468  1.00 54.48  ? 384 PRO A CG  1 
ATOM   405  C CD  . PRO A 1 52  ? 15.730  2.265   23.012  1.00 44.07  ? 384 PRO A CD  1 
ATOM   406  N N   . THR A 1 53  ? 19.162  1.445   23.921  1.00 65.04  ? 385 THR A N   1 
ATOM   407  C CA  . THR A 1 53  ? 20.416  0.740   24.154  1.00 59.85  ? 385 THR A CA  1 
ATOM   408  C C   . THR A 1 53  ? 21.577  1.330   23.363  1.00 56.03  ? 385 THR A C   1 
ATOM   409  O O   . THR A 1 53  ? 22.734  1.036   23.682  1.00 69.56  ? 385 THR A O   1 
ATOM   410  C CB  . THR A 1 53  ? 20.258  -0.749  23.823  1.00 64.28  ? 385 THR A CB  1 
ATOM   411  O OG1 . THR A 1 53  ? 19.913  -0.908  22.440  1.00 61.89  ? 385 THR A OG1 1 
ATOM   412  C CG2 . THR A 1 53  ? 19.170  -1.382  24.693  1.00 55.58  ? 385 THR A CG2 1 
ATOM   413  N N   . LYS A 1 54  ? 21.304  2.154   22.353  1.00 57.25  ? 386 LYS A N   1 
ATOM   414  C CA  . LYS A 1 54  ? 22.339  2.843   21.596  1.00 59.67  ? 386 LYS A CA  1 
ATOM   415  C C   . LYS A 1 54  ? 22.455  4.315   21.970  1.00 80.61  ? 386 LYS A C   1 
ATOM   416  O O   . LYS A 1 54  ? 23.138  5.069   21.271  1.00 84.25  ? 386 LYS A O   1 
ATOM   417  C CB  . LYS A 1 54  ? 22.070  2.713   20.096  1.00 51.36  ? 386 LYS A CB  1 
ATOM   418  C CG  . LYS A 1 54  ? 21.755  1.300   19.637  1.00 66.98  ? 386 LYS A CG  1 
ATOM   419  C CD  . LYS A 1 54  ? 21.343  1.287   18.173  1.00 73.66  ? 386 LYS A CD  1 
ATOM   420  C CE  . LYS A 1 54  ? 20.766  -0.061  17.765  1.00 62.82  ? 386 LYS A CE  1 
ATOM   421  N NZ  . LYS A 1 54  ? 21.729  -1.174  17.989  1.00 73.74  ? 386 LYS A NZ  1 
ATOM   422  N N   . LEU A 1 55  ? 21.802  4.740   23.054  1.00 81.18  ? 387 LEU A N   1 
ATOM   423  C CA  . LEU A 1 55  ? 21.747  6.154   23.405  1.00 70.88  ? 387 LEU A CA  1 
ATOM   424  C C   . LEU A 1 55  ? 23.082  6.709   23.882  1.00 78.93  ? 387 LEU A C   1 
ATOM   425  O O   . LEU A 1 55  ? 23.224  7.934   23.972  1.00 82.61  ? 387 LEU A O   1 
ATOM   426  C CB  . LEU A 1 55  ? 20.679  6.379   24.474  1.00 73.73  ? 387 LEU A CB  1 
ATOM   427  C CG  . LEU A 1 55  ? 19.297  6.757   23.943  1.00 73.11  ? 387 LEU A CG  1 
ATOM   428  C CD1 . LEU A 1 55  ? 18.287  6.846   25.076  1.00 64.59  ? 387 LEU A CD1 1 
ATOM   429  C CD2 . LEU A 1 55  ? 19.372  8.070   23.177  1.00 58.32  ? 387 LEU A CD2 1 
ATOM   430  N N   . ASN A 1 56  ? 24.057  5.853   24.183  1.00 91.90  ? 388 ASN A N   1 
ATOM   431  C CA  . ASN A 1 56  ? 25.381  6.291   24.600  1.00 81.76  ? 388 ASN A CA  1 
ATOM   432  C C   . ASN A 1 56  ? 26.326  6.509   23.421  1.00 81.68  ? 388 ASN A C   1 
ATOM   433  O O   . ASN A 1 56  ? 27.543  6.579   23.618  1.00 92.17  ? 388 ASN A O   1 
ATOM   434  C CB  . ASN A 1 56  ? 25.982  5.284   25.585  1.00 74.33  ? 388 ASN A CB  1 
ATOM   435  C CG  . ASN A 1 56  ? 25.297  5.316   26.942  1.00 73.42  ? 388 ASN A CG  1 
ATOM   436  O OD1 . ASN A 1 56  ? 24.252  5.944   27.108  1.00 86.99  ? 388 ASN A OD1 1 
ATOM   437  N ND2 . ASN A 1 56  ? 25.885  4.636   27.919  1.00 61.07  ? 388 ASN A ND2 1 
ATOM   438  N N   . ASP A 1 57  ? 25.791  6.624   22.202  1.00 90.73  ? 389 ASP A N   1 
ATOM   439  C CA  . ASP A 1 57  ? 26.599  6.869   21.013  1.00 88.96  ? 389 ASP A CA  1 
ATOM   440  C C   . ASP A 1 57  ? 25.929  7.886   20.094  1.00 90.05  ? 389 ASP A C   1 
ATOM   441  O O   . ASP A 1 57  ? 26.157  7.877   18.879  1.00 99.36  ? 389 ASP A O   1 
ATOM   442  C CB  . ASP A 1 57  ? 26.854  5.563   20.246  1.00 95.43  ? 389 ASP A CB  1 
ATOM   443  C CG  . ASP A 1 57  ? 27.991  5.679   19.232  1.00 119.29 ? 389 ASP A CG  1 
ATOM   444  O OD1 . ASP A 1 57  ? 28.225  4.697   18.496  1.00 113.33 ? 389 ASP A OD1 1 
ATOM   445  O OD2 . ASP A 1 57  ? 28.659  6.735   19.178  1.00 118.68 ? 389 ASP A OD2 1 
ATOM   446  N N   . LEU A 1 58  ? 25.097  8.763   20.645  1.00 87.58  ? 390 LEU A N   1 
ATOM   447  C CA  . LEU A 1 58  ? 24.301  9.669   19.834  1.00 93.01  ? 390 LEU A CA  1 
ATOM   448  C C   . LEU A 1 58  ? 24.482  11.102  20.314  1.00 96.52  ? 390 LEU A C   1 
ATOM   449  O O   . LEU A 1 58  ? 24.748  11.351  21.494  1.00 84.58  ? 390 LEU A O   1 
ATOM   450  C CB  . LEU A 1 58  ? 22.816  9.281   19.872  1.00 82.63  ? 390 LEU A CB  1 
ATOM   451  C CG  . LEU A 1 58  ? 22.462  7.800   19.689  1.00 82.80  ? 390 LEU A CG  1 
ATOM   452  C CD1 . LEU A 1 58  ? 20.958  7.591   19.777  1.00 84.09  ? 390 LEU A CD1 1 
ATOM   453  C CD2 . LEU A 1 58  ? 22.998  7.252   18.375  1.00 80.68  ? 390 LEU A CD2 1 
ATOM   454  N N   . CYS A 1 59  ? 24.345  12.043  19.380  1.00 84.13  ? 391 CYS A N   1 
ATOM   455  C CA  . CYS A 1 59  ? 24.408  13.471  19.673  1.00 86.74  ? 391 CYS A CA  1 
ATOM   456  C C   . CYS A 1 59  ? 23.148  14.139  19.145  1.00 83.42  ? 391 CYS A C   1 
ATOM   457  O O   . CYS A 1 59  ? 22.844  14.041  17.952  1.00 97.53  ? 391 CYS A O   1 
ATOM   458  C CB  . CYS A 1 59  ? 25.647  14.120  19.049  1.00 106.03 ? 391 CYS A CB  1 
ATOM   459  S SG  . CYS A 1 59  ? 27.216  13.801  19.894  1.00 128.53 ? 391 CYS A SG  1 
ATOM   460  N N   . PHE A 1 60  ? 22.428  14.825  20.027  1.00 83.31  ? 392 PHE A N   1 
ATOM   461  C CA  . PHE A 1 60  ? 21.211  15.537  19.674  1.00 84.21  ? 392 PHE A CA  1 
ATOM   462  C C   . PHE A 1 60  ? 21.386  17.023  19.948  1.00 82.79  ? 392 PHE A C   1 
ATOM   463  O O   . PHE A 1 60  ? 22.375  17.460  20.544  1.00 76.55  ? 392 PHE A O   1 
ATOM   464  C CB  . PHE A 1 60  ? 20.005  15.008  20.460  1.00 73.87  ? 392 PHE A CB  1 
ATOM   465  C CG  . PHE A 1 60  ? 19.958  13.514  20.571  1.00 73.53  ? 392 PHE A CG  1 
ATOM   466  C CD1 . PHE A 1 60  ? 20.581  12.866  21.625  1.00 77.22  ? 392 PHE A CD1 1 
ATOM   467  C CD2 . PHE A 1 60  ? 19.279  12.757  19.632  1.00 67.78  ? 392 PHE A CD2 1 
ATOM   468  C CE1 . PHE A 1 60  ? 20.537  11.493  21.734  1.00 71.65  ? 392 PHE A CE1 1 
ATOM   469  C CE2 . PHE A 1 60  ? 19.230  11.384  19.737  1.00 62.78  ? 392 PHE A CE2 1 
ATOM   470  C CZ  . PHE A 1 60  ? 19.857  10.752  20.791  1.00 73.07  ? 392 PHE A CZ  1 
ATOM   471  N N   . THR A 1 61  ? 20.397  17.805  19.515  1.00 81.89  ? 393 THR A N   1 
ATOM   472  C CA  . THR A 1 61  ? 20.396  19.226  19.842  1.00 85.05  ? 393 THR A CA  1 
ATOM   473  C C   . THR A 1 61  ? 19.843  19.472  21.242  1.00 86.27  ? 393 THR A C   1 
ATOM   474  O O   . THR A 1 61  ? 20.416  20.256  22.008  1.00 78.60  ? 393 THR A O   1 
ATOM   475  C CB  . THR A 1 61  ? 19.600  20.011  18.796  1.00 92.27  ? 393 THR A CB  1 
ATOM   476  O OG1 . THR A 1 61  ? 18.418  19.284  18.440  1.00 97.81  ? 393 THR A OG1 1 
ATOM   477  C CG2 . THR A 1 61  ? 20.441  20.242  17.549  1.00 84.70  ? 393 THR A CG2 1 
ATOM   478  N N   . ASN A 1 62  ? 18.745  18.805  21.598  1.00 85.59  ? 394 ASN A N   1 
ATOM   479  C CA  . ASN A 1 62  ? 18.168  18.918  22.930  1.00 67.52  ? 394 ASN A CA  1 
ATOM   480  C C   . ASN A 1 62  ? 17.446  17.628  23.284  1.00 62.78  ? 394 ASN A C   1 
ATOM   481  O O   . ASN A 1 62  ? 17.049  16.852  22.411  1.00 64.95  ? 394 ASN A O   1 
ATOM   482  C CB  . ASN A 1 62  ? 17.188  20.092  23.041  1.00 73.68  ? 394 ASN A CB  1 
ATOM   483  C CG  . ASN A 1 62  ? 17.887  21.424  23.148  1.00 76.42  ? 394 ASN A CG  1 
ATOM   484  O OD1 . ASN A 1 62  ? 17.463  22.410  22.548  1.00 85.51  ? 394 ASN A OD1 1 
ATOM   485  N ND2 . ASN A 1 62  ? 18.972  21.461  23.911  1.00 73.13  ? 394 ASN A ND2 1 
ATOM   486  N N   . VAL A 1 63  ? 17.271  17.418  24.584  1.00 53.37  ? 395 VAL A N   1 
ATOM   487  C CA  . VAL A 1 63  ? 16.484  16.312  25.112  1.00 44.22  ? 395 VAL A CA  1 
ATOM   488  C C   . VAL A 1 63  ? 15.480  16.888  26.096  1.00 61.59  ? 395 VAL A C   1 
ATOM   489  O O   . VAL A 1 63  ? 15.850  17.661  26.987  1.00 59.54  ? 395 VAL A O   1 
ATOM   490  C CB  . VAL A 1 63  ? 17.365  15.248  25.792  1.00 51.92  ? 395 VAL A CB  1 
ATOM   491  C CG1 . VAL A 1 63  ? 16.499  14.231  26.515  1.00 48.21  ? 395 VAL A CG1 1 
ATOM   492  C CG2 . VAL A 1 63  ? 18.252  14.559  24.765  1.00 58.63  ? 395 VAL A CG2 1 
ATOM   493  N N   . TYR A 1 64  ? 14.213  16.523  25.933  1.00 51.02  ? 396 TYR A N   1 
ATOM   494  C CA  . TYR A 1 64  ? 13.148  16.993  26.802  1.00 38.39  ? 396 TYR A CA  1 
ATOM   495  C C   . TYR A 1 64  ? 12.700  15.867  27.723  1.00 40.84  ? 396 TYR A C   1 
ATOM   496  O O   . TYR A 1 64  ? 12.596  14.711  27.300  1.00 51.31  ? 396 TYR A O   1 
ATOM   497  C CB  . TYR A 1 64  ? 11.962  17.513  25.987  1.00 46.26  ? 396 TYR A CB  1 
ATOM   498  C CG  . TYR A 1 64  ? 12.266  18.771  25.205  1.00 48.79  ? 396 TYR A CG  1 
ATOM   499  C CD1 . TYR A 1 64  ? 12.485  19.977  25.856  1.00 46.71  ? 396 TYR A CD1 1 
ATOM   500  C CD2 . TYR A 1 64  ? 12.327  18.755  23.817  1.00 48.42  ? 396 TYR A CD2 1 
ATOM   501  C CE1 . TYR A 1 64  ? 12.758  21.130  25.151  1.00 41.58  ? 396 TYR A CE1 1 
ATOM   502  C CE2 . TYR A 1 64  ? 12.600  19.905  23.103  1.00 47.39  ? 396 TYR A CE2 1 
ATOM   503  C CZ  . TYR A 1 64  ? 12.814  21.090  23.776  1.00 46.94  ? 396 TYR A CZ  1 
ATOM   504  O OH  . TYR A 1 64  ? 13.088  22.243  23.077  1.00 56.47  ? 396 TYR A OH  1 
ATOM   505  N N   . ALA A 1 65  ? 12.449  16.208  28.985  1.00 36.35  ? 397 ALA A N   1 
ATOM   506  C CA  . ALA A 1 65  ? 11.974  15.256  29.984  1.00 32.85  ? 397 ALA A CA  1 
ATOM   507  C C   . ALA A 1 65  ? 10.636  15.752  30.514  1.00 36.08  ? 397 ALA A C   1 
ATOM   508  O O   . ALA A 1 65  ? 10.581  16.759  31.230  1.00 37.11  ? 397 ALA A O   1 
ATOM   509  C CB  . ALA A 1 65  ? 12.989  15.088  31.114  1.00 34.65  ? 397 ALA A CB  1 
ATOM   510  N N   . ASP A 1 66  ? 9.565   15.048  30.165  1.00 32.46  ? 398 ASP A N   1 
ATOM   511  C CA  . ASP A 1 66  ? 8.219   15.415  30.578  1.00 34.55  ? 398 ASP A CA  1 
ATOM   512  C C   . ASP A 1 66  ? 7.782   14.491  31.708  1.00 33.33  ? 398 ASP A C   1 
ATOM   513  O O   . ASP A 1 66  ? 7.863   13.266  31.578  1.00 38.70  ? 398 ASP A O   1 
ATOM   514  C CB  . ASP A 1 66  ? 7.240   15.335  29.401  1.00 37.38  ? 398 ASP A CB  1 
ATOM   515  C CG  . ASP A 1 66  ? 7.608   16.280  28.249  1.00 44.80  ? 398 ASP A CG  1 
ATOM   516  O OD1 . ASP A 1 66  ? 8.222   17.344  28.488  1.00 37.16  ? 398 ASP A OD1 1 
ATOM   517  O OD2 . ASP A 1 66  ? 7.263   15.957  27.092  1.00 44.05  ? 398 ASP A OD2 1 
ATOM   518  N N   . SER A 1 67  ? 7.336   15.078  32.816  1.00 34.27  ? 399 SER A N   1 
ATOM   519  C CA  . SER A 1 67  ? 6.991   14.337  34.020  1.00 30.81  ? 399 SER A CA  1 
ATOM   520  C C   . SER A 1 67  ? 5.555   14.631  34.419  1.00 33.56  ? 399 SER A C   1 
ATOM   521  O O   . SER A 1 67  ? 5.110   15.782  34.363  1.00 44.39  ? 399 SER A O   1 
ATOM   522  C CB  . SER A 1 67  ? 7.924   14.701  35.178  1.00 37.71  ? 399 SER A CB  1 
ATOM   523  O OG  . SER A 1 67  ? 9.273   14.700  34.755  1.00 37.21  ? 399 SER A OG  1 
ATOM   524  N N   . PHE A 1 68  ? 4.837   13.589  34.824  1.00 27.75  ? 400 PHE A N   1 
ATOM   525  C CA  . PHE A 1 68  ? 3.479   13.728  35.333  1.00 23.62  ? 400 PHE A CA  1 
ATOM   526  C C   . PHE A 1 68  ? 3.070   12.395  35.944  1.00 33.16  ? 400 PHE A C   1 
ATOM   527  O O   . PHE A 1 68  ? 3.777   11.391  35.817  1.00 37.61  ? 400 PHE A O   1 
ATOM   528  C CB  . PHE A 1 68  ? 2.501   14.165  34.238  1.00 28.55  ? 400 PHE A CB  1 
ATOM   529  C CG  . PHE A 1 68  ? 2.593   13.352  32.979  1.00 31.78  ? 400 PHE A CG  1 
ATOM   530  C CD1 . PHE A 1 68  ? 3.454   13.724  31.959  1.00 30.44  ? 400 PHE A CD1 1 
ATOM   531  C CD2 . PHE A 1 68  ? 1.811   12.222  32.810  1.00 39.13  ? 400 PHE A CD2 1 
ATOM   532  C CE1 . PHE A 1 68  ? 3.539   12.979  30.798  1.00 30.58  ? 400 PHE A CE1 1 
ATOM   533  C CE2 . PHE A 1 68  ? 1.890   11.474  31.652  1.00 29.92  ? 400 PHE A CE2 1 
ATOM   534  C CZ  . PHE A 1 68  ? 2.754   11.852  30.645  1.00 30.36  ? 400 PHE A CZ  1 
ATOM   535  N N   . VAL A 1 69  ? 1.922   12.400  36.618  1.00 36.85  ? 401 VAL A N   1 
ATOM   536  C CA  . VAL A 1 69  ? 1.377   11.213  37.269  1.00 40.29  ? 401 VAL A CA  1 
ATOM   537  C C   . VAL A 1 69  ? -0.025  10.960  36.736  1.00 39.00  ? 401 VAL A C   1 
ATOM   538  O O   . VAL A 1 69  ? -0.854  11.876  36.692  1.00 43.11  ? 401 VAL A O   1 
ATOM   539  C CB  . VAL A 1 69  ? 1.355   11.356  38.802  1.00 41.64  ? 401 VAL A CB  1 
ATOM   540  C CG1 . VAL A 1 69  ? 0.285   10.459  39.407  1.00 35.13  ? 401 VAL A CG1 1 
ATOM   541  C CG2 . VAL A 1 69  ? 2.707   11.004  39.373  1.00 45.75  ? 401 VAL A CG2 1 
ATOM   542  N N   . ILE A 1 70  ? -0.285  9.715   36.340  1.00 41.13  ? 402 ILE A N   1 
ATOM   543  C CA  . ILE A 1 70  ? -1.578  9.277   35.836  1.00 38.41  ? 402 ILE A CA  1 
ATOM   544  C C   . ILE A 1 70  ? -1.916  7.935   36.475  1.00 38.71  ? 402 ILE A C   1 
ATOM   545  O O   . ILE A 1 70  ? -1.153  7.394   37.278  1.00 43.55  ? 402 ILE A O   1 
ATOM   546  C CB  . ILE A 1 70  ? -1.594  9.164   34.297  1.00 44.44  ? 402 ILE A CB  1 
ATOM   547  C CG1 . ILE A 1 70  ? -0.466  8.244   33.823  1.00 36.83  ? 402 ILE A CG1 1 
ATOM   548  C CG2 . ILE A 1 70  ? -1.492  10.543  33.657  1.00 47.73  ? 402 ILE A CG2 1 
ATOM   549  C CD1 . ILE A 1 70  ? -0.310  8.186   32.320  1.00 32.48  ? 402 ILE A CD1 1 
ATOM   550  N N   . ARG A 1 71  ? -3.076  7.397   36.112  1.00 38.05  ? 403 ARG A N   1 
ATOM   551  C CA  . ARG A 1 71  ? -3.479  6.084   36.585  1.00 32.90  ? 403 ARG A CA  1 
ATOM   552  C C   . ARG A 1 71  ? -2.832  4.991   35.740  1.00 40.95  ? 403 ARG A C   1 
ATOM   553  O O   . ARG A 1 71  ? -2.239  5.245   34.688  1.00 46.92  ? 403 ARG A O   1 
ATOM   554  C CB  . ARG A 1 71  ? -4.999  5.944   36.551  1.00 33.93  ? 403 ARG A CB  1 
ATOM   555  C CG  . ARG A 1 71  ? -5.722  6.804   37.562  1.00 44.46  ? 403 ARG A CG  1 
ATOM   556  C CD  . ARG A 1 71  ? -7.224  6.613   37.459  1.00 48.40  ? 403 ARG A CD  1 
ATOM   557  N NE  . ARG A 1 71  ? -7.566  5.255   37.057  1.00 56.07  ? 403 ARG A NE  1 
ATOM   558  C CZ  . ARG A 1 71  ? -8.740  4.680   37.280  1.00 57.33  ? 403 ARG A CZ  1 
ATOM   559  N NH1 . ARG A 1 71  ? -9.702  5.306   37.938  1.00 62.87  ? 403 ARG A NH1 1 
ATOM   560  N NH2 . ARG A 1 71  ? -8.951  3.443   36.839  1.00 53.68  ? 403 ARG A NH2 1 
ATOM   561  N N   . GLY A 1 72  ? -2.956  3.751   36.216  1.00 38.82  ? 404 GLY A N   1 
ATOM   562  C CA  . GLY A 1 72  ? -2.452  2.623   35.451  1.00 44.58  ? 404 GLY A CA  1 
ATOM   563  C C   . GLY A 1 72  ? -3.174  2.433   34.130  1.00 53.18  ? 404 GLY A C   1 
ATOM   564  O O   . GLY A 1 72  ? -2.539  2.204   33.096  1.00 51.52  ? 404 GLY A O   1 
ATOM   565  N N   . ASP A 1 73  ? -4.507  2.536   34.138  1.00 44.20  ? 405 ASP A N   1 
ATOM   566  C CA  . ASP A 1 73  ? -5.267  2.369   32.903  1.00 45.06  ? 405 ASP A CA  1 
ATOM   567  C C   . ASP A 1 73  ? -4.940  3.442   31.878  1.00 47.95  ? 405 ASP A C   1 
ATOM   568  O O   . ASP A 1 73  ? -5.129  3.219   30.678  1.00 44.09  ? 405 ASP A O   1 
ATOM   569  C CB  . ASP A 1 73  ? -6.767  2.388   33.191  1.00 56.65  ? 405 ASP A CB  1 
ATOM   570  C CG  . ASP A 1 73  ? -7.116  1.690   34.480  1.00 63.44  ? 405 ASP A CG  1 
ATOM   571  O OD1 . ASP A 1 73  ? -6.964  2.319   35.545  1.00 53.49  ? 405 ASP A OD1 1 
ATOM   572  O OD2 . ASP A 1 73  ? -7.534  0.515   34.429  1.00 76.26  ? 405 ASP A OD2 1 
ATOM   573  N N   . GLU A 1 74  ? -4.455  4.595   32.325  1.00 37.76  ? 406 GLU A N   1 
ATOM   574  C CA  . GLU A 1 74  ? -4.171  5.723   31.454  1.00 32.73  ? 406 GLU A CA  1 
ATOM   575  C C   . GLU A 1 74  ? -2.758  5.696   30.884  1.00 39.22  ? 406 GLU A C   1 
ATOM   576  O O   . GLU A 1 74  ? -2.429  6.544   30.047  1.00 44.96  ? 406 GLU A O   1 
ATOM   577  C CB  . GLU A 1 74  ? -4.411  7.029   32.216  1.00 33.25  ? 406 GLU A CB  1 
ATOM   578  C CG  . GLU A 1 74  ? -5.843  7.183   32.725  1.00 37.64  ? 406 GLU A CG  1 
ATOM   579  C CD  . GLU A 1 74  ? -5.993  8.285   33.759  1.00 44.87  ? 406 GLU A CD  1 
ATOM   580  O OE1 . GLU A 1 74  ? -4.963  8.711   34.322  1.00 46.33  ? 406 GLU A OE1 1 
ATOM   581  O OE2 . GLU A 1 74  ? -7.136  8.726   34.010  1.00 52.12  ? 406 GLU A OE2 1 
ATOM   582  N N   . VAL A 1 75  ? -1.918  4.751   31.310  1.00 35.37  ? 407 VAL A N   1 
ATOM   583  C CA  . VAL A 1 75  ? -0.557  4.689   30.790  1.00 30.93  ? 407 VAL A CA  1 
ATOM   584  C C   . VAL A 1 75  ? -0.569  4.340   29.306  1.00 39.62  ? 407 VAL A C   1 
ATOM   585  O O   . VAL A 1 75  ? 0.278   4.806   28.533  1.00 39.68  ? 407 VAL A O   1 
ATOM   586  C CB  . VAL A 1 75  ? 0.284   3.691   31.609  1.00 35.66  ? 407 VAL A CB  1 
ATOM   587  C CG1 . VAL A 1 75  ? 1.700   3.626   31.067  1.00 36.67  ? 407 VAL A CG1 1 
ATOM   588  C CG2 . VAL A 1 75  ? 0.304   4.106   33.066  1.00 38.74  ? 407 VAL A CG2 1 
ATOM   589  N N   . ARG A 1 76  ? -1.532  3.516   28.885  1.00 44.90  ? 408 ARG A N   1 
ATOM   590  C CA  . ARG A 1 76  ? -1.661  3.155   27.478  1.00 40.62  ? 408 ARG A CA  1 
ATOM   591  C C   . ARG A 1 76  ? -1.963  4.360   26.597  1.00 33.97  ? 408 ARG A C   1 
ATOM   592  O O   . ARG A 1 76  ? -1.708  4.315   25.387  1.00 33.53  ? 408 ARG A O   1 
ATOM   593  C CB  . ARG A 1 76  ? -2.759  2.102   27.312  1.00 51.78  ? 408 ARG A CB  1 
ATOM   594  C CG  . ARG A 1 76  ? -4.167  2.638   27.504  1.00 46.03  ? 408 ARG A CG  1 
ATOM   595  C CD  . ARG A 1 76  ? -5.156  1.510   27.714  1.00 56.22  ? 408 ARG A CD  1 
ATOM   596  N NE  . ARG A 1 76  ? -4.895  0.784   28.953  1.00 59.94  ? 408 ARG A NE  1 
ATOM   597  C CZ  . ARG A 1 76  ? -5.728  -0.094  29.493  1.00 64.47  ? 408 ARG A CZ  1 
ATOM   598  N NH1 . ARG A 1 76  ? -6.893  -0.375  28.933  1.00 73.91  ? 408 ARG A NH1 1 
ATOM   599  N NH2 . ARG A 1 76  ? -5.387  -0.704  30.626  1.00 64.20  ? 408 ARG A NH2 1 
ATOM   600  N N   . GLN A 1 77  ? -2.493  5.437   27.174  1.00 38.32  ? 409 GLN A N   1 
ATOM   601  C CA  . GLN A 1 77  ? -2.802  6.629   26.399  1.00 35.36  ? 409 GLN A CA  1 
ATOM   602  C C   . GLN A 1 77  ? -1.567  7.457   26.062  1.00 35.19  ? 409 GLN A C   1 
ATOM   603  O O   . GLN A 1 77  ? -1.642  8.311   25.173  1.00 35.58  ? 409 GLN A O   1 
ATOM   604  C CB  . GLN A 1 77  ? -3.817  7.494   27.148  1.00 33.15  ? 409 GLN A CB  1 
ATOM   605  C CG  . GLN A 1 77  ? -5.155  6.812   27.377  1.00 30.27  ? 409 GLN A CG  1 
ATOM   606  C CD  . GLN A 1 77  ? -6.192  7.756   27.946  1.00 37.83  ? 409 GLN A CD  1 
ATOM   607  O OE1 . GLN A 1 77  ? -6.087  8.974   27.794  1.00 30.44  ? 409 GLN A OE1 1 
ATOM   608  N NE2 . GLN A 1 77  ? -7.199  7.200   28.609  1.00 55.25  ? 409 GLN A NE2 1 
ATOM   609  N N   . ILE A 1 78  ? -0.439  7.223   26.728  1.00 35.50  ? 410 ILE A N   1 
ATOM   610  C CA  . ILE A 1 78  ? 0.793   7.984   26.444  1.00 32.83  ? 410 ILE A CA  1 
ATOM   611  C C   . ILE A 1 78  ? 1.502   7.233   25.325  1.00 30.25  ? 410 ILE A C   1 
ATOM   612  O O   . ILE A 1 78  ? 2.459   6.481   25.528  1.00 40.04  ? 410 ILE A O   1 
ATOM   613  C CB  . ILE A 1 78  ? 1.665   8.165   27.691  1.00 32.81  ? 410 ILE A CB  1 
ATOM   614  C CG1 . ILE A 1 78  ? 0.814   8.662   28.860  1.00 30.94  ? 410 ILE A CG1 1 
ATOM   615  C CG2 . ILE A 1 78  ? 2.810   9.141   27.416  1.00 25.61  ? 410 ILE A CG2 1 
ATOM   616  C CD1 . ILE A 1 78  ? 0.113   9.978   28.593  1.00 29.17  ? 410 ILE A CD1 1 
ATOM   617  N N   . ALA A 1 79  ? 1.034   7.468   24.100  1.00 35.92  ? 411 ALA A N   1 
ATOM   618  C CA  . ALA A 1 79  ? 1.541   6.825   22.896  1.00 35.12  ? 411 ALA A CA  1 
ATOM   619  C C   . ALA A 1 79  ? 1.022   7.579   21.679  1.00 40.74  ? 411 ALA A C   1 
ATOM   620  O O   . ALA A 1 79  ? -0.058  8.184   21.741  1.00 46.17  ? 411 ALA A O   1 
ATOM   621  C CB  . ALA A 1 79  ? 1.120   5.356   22.843  1.00 34.13  ? 411 ALA A CB  1 
ATOM   622  N N   . PRO A 1 80  ? 1.756   7.581   20.566  1.00 36.45  ? 412 PRO A N   1 
ATOM   623  C CA  . PRO A 1 80  ? 1.278   8.295   19.377  1.00 36.80  ? 412 PRO A CA  1 
ATOM   624  C C   . PRO A 1 80  ? -0.045  7.728   18.884  1.00 44.09  ? 412 PRO A C   1 
ATOM   625  O O   . PRO A 1 80  ? -0.286  6.520   18.939  1.00 38.88  ? 412 PRO A O   1 
ATOM   626  C CB  . PRO A 1 80  ? 2.402   8.078   18.357  1.00 34.04  ? 412 PRO A CB  1 
ATOM   627  C CG  . PRO A 1 80  ? 3.118   6.857   18.835  1.00 31.18  ? 412 PRO A CG  1 
ATOM   628  C CD  . PRO A 1 80  ? 3.049   6.918   20.329  1.00 27.97  ? 412 PRO A CD  1 
ATOM   629  N N   . GLY A 1 81  ? -0.907  8.620   18.406  1.00 41.87  ? 413 GLY A N   1 
ATOM   630  C CA  . GLY A 1 81  ? -2.193  8.203   17.868  1.00 34.06  ? 413 GLY A CA  1 
ATOM   631  C C   . GLY A 1 81  ? -3.110  7.542   18.874  1.00 30.24  ? 413 GLY A C   1 
ATOM   632  O O   . GLY A 1 81  ? -3.731  6.519   18.564  1.00 42.25  ? 413 GLY A O   1 
ATOM   633  N N   . GLN A 1 82  ? -3.217  8.106   20.073  1.00 45.96  ? 414 GLN A N   1 
ATOM   634  C CA  . GLN A 1 82  ? -4.065  7.555   21.118  1.00 35.05  ? 414 GLN A CA  1 
ATOM   635  C C   . GLN A 1 82  ? -5.109  8.581   21.540  1.00 36.32  ? 414 GLN A C   1 
ATOM   636  O O   . GLN A 1 82  ? -4.871  9.792   21.486  1.00 50.20  ? 414 GLN A O   1 
ATOM   637  C CB  . GLN A 1 82  ? -3.233  7.117   22.329  1.00 39.35  ? 414 GLN A CB  1 
ATOM   638  C CG  . GLN A 1 82  ? -3.711  5.822   22.970  1.00 47.34  ? 414 GLN A CG  1 
ATOM   639  C CD  . GLN A 1 82  ? -3.473  4.607   22.091  1.00 54.01  ? 414 GLN A CD  1 
ATOM   640  O OE1 . GLN A 1 82  ? -2.685  4.650   21.144  1.00 52.74  ? 414 GLN A OE1 1 
ATOM   641  N NE2 . GLN A 1 82  ? -4.155  3.511   22.406  1.00 60.75  ? 414 GLN A NE2 1 
ATOM   642  N N   . THR A 1 83  ? -6.274  8.087   21.955  1.00 35.30  ? 415 THR A N   1 
ATOM   643  C CA  . THR A 1 83  ? -7.390  8.926   22.366  1.00 32.23  ? 415 THR A CA  1 
ATOM   644  C C   . THR A 1 83  ? -7.827  8.569   23.780  1.00 37.88  ? 415 THR A C   1 
ATOM   645  O O   . THR A 1 83  ? -7.603  7.457   24.265  1.00 42.01  ? 415 THR A O   1 
ATOM   646  C CB  . THR A 1 83  ? -8.585  8.789   21.414  1.00 35.49  ? 415 THR A CB  1 
ATOM   647  O OG1 . THR A 1 83  ? -8.990  7.416   21.342  1.00 45.73  ? 415 THR A OG1 1 
ATOM   648  C CG2 . THR A 1 83  ? -8.218  9.284   20.029  1.00 25.23  ? 415 THR A CG2 1 
ATOM   649  N N   . GLY A 1 84  ? -8.458  9.529   24.431  1.00 31.21  ? 416 GLY A N   1 
ATOM   650  C CA  . GLY A 1 84  ? -8.863  9.380   25.816  1.00 35.41  ? 416 GLY A CA  1 
ATOM   651  C C   . GLY A 1 84  ? -8.788  10.708  26.534  1.00 41.49  ? 416 GLY A C   1 
ATOM   652  O O   . GLY A 1 84  ? -8.286  11.700  26.013  1.00 42.89  ? 416 GLY A O   1 
ATOM   653  N N   . LYS A 1 85  ? -9.296  10.709  27.769  1.00 40.84  ? 417 LYS A N   1 
ATOM   654  C CA  . LYS A 1 85  ? -9.338  11.947  28.542  1.00 28.35  ? 417 LYS A CA  1 
ATOM   655  C C   . LYS A 1 85  ? -7.940  12.502  28.783  1.00 31.50  ? 417 LYS A C   1 
ATOM   656  O O   . LYS A 1 85  ? -7.721  13.715  28.683  1.00 45.90  ? 417 LYS A O   1 
ATOM   657  C CB  . LYS A 1 85  ? -10.064 11.718  29.867  1.00 22.01  ? 417 LYS A CB  1 
ATOM   658  C CG  . LYS A 1 85  ? -11.572 11.851  29.766  1.00 39.13  ? 417 LYS A CG  1 
ATOM   659  C CD  . LYS A 1 85  ? -12.258 11.503  31.075  1.00 33.30  ? 417 LYS A CD  1 
ATOM   660  C CE  . LYS A 1 85  ? -12.227 10.007  31.331  1.00 56.92  ? 417 LYS A CE  1 
ATOM   661  N NZ  . LYS A 1 85  ? -13.048 9.624   32.513  1.00 63.15  ? 417 LYS A NZ  1 
ATOM   662  N N   . ILE A 1 86  ? -6.984  11.636  29.115  1.00 34.08  ? 418 ILE A N   1 
ATOM   663  C CA  . ILE A 1 86  ? -5.620  12.107  29.337  1.00 40.65  ? 418 ILE A CA  1 
ATOM   664  C C   . ILE A 1 86  ? -4.971  12.510  28.017  1.00 42.83  ? 418 ILE A C   1 
ATOM   665  O O   . ILE A 1 86  ? -4.330  13.565  27.920  1.00 37.95  ? 418 ILE A O   1 
ATOM   666  C CB  . ILE A 1 86  ? -4.801  11.039  30.090  1.00 25.90  ? 418 ILE A CB  1 
ATOM   667  C CG1 . ILE A 1 86  ? -4.790  11.339  31.590  1.00 27.70  ? 418 ILE A CG1 1 
ATOM   668  C CG2 . ILE A 1 86  ? -3.369  10.989  29.587  1.00 28.60  ? 418 ILE A CG2 1 
ATOM   669  C CD1 . ILE A 1 86  ? -6.158  11.575  32.189  1.00 41.83  ? 418 ILE A CD1 1 
ATOM   670  N N   . ALA A 1 87  ? -5.149  11.696  26.973  1.00 42.42  ? 419 ALA A N   1 
ATOM   671  C CA  . ALA A 1 87  ? -4.484  11.962  25.701  1.00 42.65  ? 419 ALA A CA  1 
ATOM   672  C C   . ALA A 1 87  ? -5.044  13.205  25.021  1.00 38.27  ? 419 ALA A C   1 
ATOM   673  O O   . ALA A 1 87  ? -4.298  13.957  24.381  1.00 40.25  ? 419 ALA A O   1 
ATOM   674  C CB  . ALA A 1 87  ? -4.608  10.747  24.780  1.00 39.00  ? 419 ALA A CB  1 
ATOM   675  N N   . ASP A 1 88  ? -6.353  13.433  25.136  1.00 37.90  ? 420 ASP A N   1 
ATOM   676  C CA  . ASP A 1 88  ? -7.003  14.533  24.431  1.00 39.26  ? 420 ASP A CA  1 
ATOM   677  C C   . ASP A 1 88  ? -6.960  15.849  25.195  1.00 37.91  ? 420 ASP A C   1 
ATOM   678  O O   . ASP A 1 88  ? -6.883  16.914  24.572  1.00 42.24  ? 420 ASP A O   1 
ATOM   679  C CB  . ASP A 1 88  ? -8.464  14.183  24.127  1.00 44.15  ? 420 ASP A CB  1 
ATOM   680  C CG  . ASP A 1 88  ? -8.609  12.924  23.285  1.00 47.29  ? 420 ASP A CG  1 
ATOM   681  O OD1 . ASP A 1 88  ? -7.689  12.614  22.497  1.00 44.91  ? 420 ASP A OD1 1 
ATOM   682  O OD2 . ASP A 1 88  ? -9.652  12.245  23.410  1.00 36.14  ? 420 ASP A OD2 1 
ATOM   683  N N   . TYR A 1 89  ? -7.004  15.809  26.528  1.00 39.39  ? 421 TYR A N   1 
ATOM   684  C CA  . TYR A 1 89  ? -7.175  17.012  27.328  1.00 27.41  ? 421 TYR A CA  1 
ATOM   685  C C   . TYR A 1 89  ? -6.003  17.341  28.241  1.00 36.80  ? 421 TYR A C   1 
ATOM   686  O O   . TYR A 1 89  ? -5.954  18.461  28.763  1.00 39.87  ? 421 TYR A O   1 
ATOM   687  C CB  . TYR A 1 89  ? -8.444  16.902  28.188  1.00 31.57  ? 421 TYR A CB  1 
ATOM   688  C CG  . TYR A 1 89  ? -9.686  16.529  27.402  1.00 35.74  ? 421 TYR A CG  1 
ATOM   689  C CD1 . TYR A 1 89  ? -9.930  17.076  26.149  1.00 30.84  ? 421 TYR A CD1 1 
ATOM   690  C CD2 . TYR A 1 89  ? -10.607 15.622  27.910  1.00 35.20  ? 421 TYR A CD2 1 
ATOM   691  C CE1 . TYR A 1 89  ? -11.058 16.735  25.428  1.00 35.38  ? 421 TYR A CE1 1 
ATOM   692  C CE2 . TYR A 1 89  ? -11.737 15.275  27.196  1.00 35.02  ? 421 TYR A CE2 1 
ATOM   693  C CZ  . TYR A 1 89  ? -11.958 15.834  25.956  1.00 32.80  ? 421 TYR A CZ  1 
ATOM   694  O OH  . TYR A 1 89  ? -13.084 15.492  25.241  1.00 34.69  ? 421 TYR A OH  1 
ATOM   695  N N   . ASN A 1 90  ? -5.073  16.416  28.462  1.00 32.73  ? 422 ASN A N   1 
ATOM   696  C CA  . ASN A 1 90  ? -3.973  16.669  29.385  1.00 25.94  ? 422 ASN A CA  1 
ATOM   697  C C   . ASN A 1 90  ? -2.605  16.600  28.726  1.00 33.09  ? 422 ASN A C   1 
ATOM   698  O O   . ASN A 1 90  ? -1.833  17.562  28.819  1.00 31.71  ? 422 ASN A O   1 
ATOM   699  C CB  . ASN A 1 90  ? -4.053  15.688  30.561  1.00 27.08  ? 422 ASN A CB  1 
ATOM   700  C CG  . ASN A 1 90  ? -5.331  15.850  31.362  1.00 32.72  ? 422 ASN A CG  1 
ATOM   701  O OD1 . ASN A 1 90  ? -5.368  16.585  32.348  1.00 38.19  ? 422 ASN A OD1 1 
ATOM   702  N ND2 . ASN A 1 90  ? -6.389  15.173  30.933  1.00 35.36  ? 422 ASN A ND2 1 
ATOM   703  N N   . TYR A 1 91  ? -2.281  15.499  28.051  1.00 33.45  ? 423 TYR A N   1 
ATOM   704  C CA  . TYR A 1 91  ? -0.956  15.332  27.460  1.00 26.99  ? 423 TYR A CA  1 
ATOM   705  C C   . TYR A 1 91  ? -1.080  14.522  26.181  1.00 26.26  ? 423 TYR A C   1 
ATOM   706  O O   . TYR A 1 91  ? -1.474  13.353  26.226  1.00 33.65  ? 423 TYR A O   1 
ATOM   707  C CB  . TYR A 1 91  ? -0.008  14.645  28.440  1.00 23.85  ? 423 TYR A CB  1 
ATOM   708  C CG  . TYR A 1 91  ? 1.422   14.538  27.958  1.00 31.51  ? 423 TYR A CG  1 
ATOM   709  C CD1 . TYR A 1 91  ? 2.315   15.587  28.136  1.00 26.06  ? 423 TYR A CD1 1 
ATOM   710  C CD2 . TYR A 1 91  ? 1.886   13.381  27.344  1.00 28.26  ? 423 TYR A CD2 1 
ATOM   711  C CE1 . TYR A 1 91  ? 3.625   15.491  27.709  1.00 21.01  ? 423 TYR A CE1 1 
ATOM   712  C CE2 . TYR A 1 91  ? 3.196   13.276  26.914  1.00 30.26  ? 423 TYR A CE2 1 
ATOM   713  C CZ  . TYR A 1 91  ? 4.060   14.334  27.098  1.00 29.65  ? 423 TYR A CZ  1 
ATOM   714  O OH  . TYR A 1 91  ? 5.366   14.235  26.669  1.00 27.07  ? 423 TYR A OH  1 
ATOM   715  N N   . LYS A 1 92  ? -0.728  15.131  25.053  1.00 26.18  ? 424 LYS A N   1 
ATOM   716  C CA  . LYS A 1 92  ? -0.886  14.515  23.743  1.00 37.45  ? 424 LYS A CA  1 
ATOM   717  C C   . LYS A 1 92  ? 0.474   14.349  23.080  1.00 42.60  ? 424 LYS A C   1 
ATOM   718  O O   . LYS A 1 92  ? 1.267   15.296  23.032  1.00 34.37  ? 424 LYS A O   1 
ATOM   719  C CB  . LYS A 1 92  ? -1.811  15.355  22.855  1.00 29.24  ? 424 LYS A CB  1 
ATOM   720  C CG  . LYS A 1 92  ? -1.988  14.816  21.441  1.00 36.31  ? 424 LYS A CG  1 
ATOM   721  C CD  . LYS A 1 92  ? -2.645  13.441  21.436  1.00 41.97  ? 424 LYS A CD  1 
ATOM   722  C CE  . LYS A 1 92  ? -2.753  12.879  20.024  1.00 39.98  ? 424 LYS A CE  1 
ATOM   723  N NZ  . LYS A 1 92  ? -3.333  11.506  20.006  1.00 42.87  ? 424 LYS A NZ  1 
ATOM   724  N N   . LEU A 1 93  ? 0.737   13.145  22.567  1.00 36.53  ? 425 LEU A N   1 
ATOM   725  C CA  . LEU A 1 93  ? 1.952   12.861  21.816  1.00 38.51  ? 425 LEU A CA  1 
ATOM   726  C C   . LEU A 1 93  ? 1.685   12.938  20.320  1.00 41.81  ? 425 LEU A C   1 
ATOM   727  O O   . LEU A 1 93  ? 0.627   12.499  19.850  1.00 46.28  ? 425 LEU A O   1 
ATOM   728  C CB  . LEU A 1 93  ? 2.497   11.474  22.160  1.00 33.51  ? 425 LEU A CB  1 
ATOM   729  C CG  . LEU A 1 93  ? 3.358   11.365  23.419  1.00 34.91  ? 425 LEU A CG  1 
ATOM   730  C CD1 . LEU A 1 93  ? 3.917   9.960   23.545  1.00 33.63  ? 425 LEU A CD1 1 
ATOM   731  C CD2 . LEU A 1 93  ? 4.481   12.392  23.399  1.00 41.05  ? 425 LEU A CD2 1 
ATOM   732  N N   . PRO A 1 94  ? 2.625   13.490  19.557  1.00 31.43  ? 426 PRO A N   1 
ATOM   733  C CA  . PRO A 1 94  ? 2.445   13.560  18.104  1.00 37.04  ? 426 PRO A CA  1 
ATOM   734  C C   . PRO A 1 94  ? 2.489   12.178  17.473  1.00 46.52  ? 426 PRO A C   1 
ATOM   735  O O   . PRO A 1 94  ? 3.061   11.233  18.022  1.00 44.57  ? 426 PRO A O   1 
ATOM   736  C CB  . PRO A 1 94  ? 3.624   14.422  17.643  1.00 38.48  ? 426 PRO A CB  1 
ATOM   737  C CG  . PRO A 1 94  ? 4.667   14.210  18.689  1.00 35.25  ? 426 PRO A CG  1 
ATOM   738  C CD  . PRO A 1 94  ? 3.924   14.039  19.986  1.00 29.74  ? 426 PRO A CD  1 
ATOM   739  N N   . ASP A 1 95  ? 1.848   12.061  16.306  1.00 48.64  ? 427 ASP A N   1 
ATOM   740  C CA  . ASP A 1 95  ? 1.831   10.786  15.596  1.00 51.08  ? 427 ASP A CA  1 
ATOM   741  C C   . ASP A 1 95  ? 3.220   10.393  15.110  1.00 54.40  ? 427 ASP A C   1 
ATOM   742  O O   . ASP A 1 95  ? 3.501   9.200   14.947  1.00 51.33  ? 427 ASP A O   1 
ATOM   743  C CB  . ASP A 1 95  ? 0.857   10.852  14.419  1.00 52.05  ? 427 ASP A CB  1 
ATOM   744  C CG  . ASP A 1 95  ? -0.551  11.220  14.847  1.00 57.10  ? 427 ASP A CG  1 
ATOM   745  O OD1 . ASP A 1 95  ? -0.922  10.921  16.003  1.00 53.36  ? 427 ASP A OD1 1 
ATOM   746  O OD2 . ASP A 1 95  ? -1.288  11.806  14.026  1.00 50.20  ? 427 ASP A OD2 1 
ATOM   747  N N   . ASP A 1 96  ? 4.093   11.371  14.866  1.00 53.58  ? 428 ASP A N   1 
ATOM   748  C CA  . ASP A 1 96  ? 5.470   11.126  14.457  1.00 50.01  ? 428 ASP A CA  1 
ATOM   749  C C   . ASP A 1 96  ? 6.437   11.191  15.637  1.00 54.21  ? 428 ASP A C   1 
ATOM   750  O O   . ASP A 1 96  ? 7.592   11.602  15.476  1.00 66.02  ? 428 ASP A O   1 
ATOM   751  C CB  . ASP A 1 96  ? 5.886   12.120  13.369  1.00 60.06  ? 428 ASP A CB  1 
ATOM   752  C CG  . ASP A 1 96  ? 5.886   13.563  13.854  1.00 65.62  ? 428 ASP A CG  1 
ATOM   753  O OD1 . ASP A 1 96  ? 5.030   13.919  14.693  1.00 65.86  ? 428 ASP A OD1 1 
ATOM   754  O OD2 . ASP A 1 96  ? 6.745   14.344  13.392  1.00 73.04  ? 428 ASP A OD2 1 
ATOM   755  N N   . PHE A 1 97  ? 5.983   10.788  16.823  1.00 42.55  ? 429 PHE A N   1 
ATOM   756  C CA  . PHE A 1 97  ? 6.789   10.928  18.028  1.00 39.91  ? 429 PHE A CA  1 
ATOM   757  C C   . PHE A 1 97  ? 8.044   10.071  17.950  1.00 37.67  ? 429 PHE A C   1 
ATOM   758  O O   . PHE A 1 97  ? 7.986   8.888   17.602  1.00 40.81  ? 429 PHE A O   1 
ATOM   759  C CB  . PHE A 1 97  ? 5.961   10.546  19.256  1.00 45.17  ? 429 PHE A CB  1 
ATOM   760  C CG  . PHE A 1 97  ? 6.755   10.478  20.531  1.00 48.11  ? 429 PHE A CG  1 
ATOM   761  C CD1 . PHE A 1 97  ? 7.244   11.631  21.125  1.00 43.59  ? 429 PHE A CD1 1 
ATOM   762  C CD2 . PHE A 1 97  ? 6.998   9.261   21.144  1.00 43.21  ? 429 PHE A CD2 1 
ATOM   763  C CE1 . PHE A 1 97  ? 7.970   11.568  22.299  1.00 38.57  ? 429 PHE A CE1 1 
ATOM   764  C CE2 . PHE A 1 97  ? 7.723   9.191   22.318  1.00 38.69  ? 429 PHE A CE2 1 
ATOM   765  C CZ  . PHE A 1 97  ? 8.209   10.347  22.896  1.00 44.17  ? 429 PHE A CZ  1 
ATOM   766  N N   . THR A 1 98  ? 9.182   10.676  18.276  1.00 44.56  ? 430 THR A N   1 
ATOM   767  C CA  . THR A 1 98  ? 10.462  9.982   18.349  1.00 40.70  ? 430 THR A CA  1 
ATOM   768  C C   . THR A 1 98  ? 10.995  10.136  19.767  1.00 47.61  ? 430 THR A C   1 
ATOM   769  O O   . THR A 1 98  ? 11.476  11.210  20.145  1.00 50.61  ? 430 THR A O   1 
ATOM   770  C CB  . THR A 1 98  ? 11.456  10.528  17.326  1.00 35.14  ? 430 THR A CB  1 
ATOM   771  O OG1 . THR A 1 98  ? 11.625  11.936  17.528  1.00 64.53  ? 430 THR A OG1 1 
ATOM   772  C CG2 . THR A 1 98  ? 10.955  10.276  15.920  1.00 33.51  ? 430 THR A CG2 1 
ATOM   773  N N   . GLY A 1 99  ? 10.909  9.063   20.544  1.00 46.78  ? 431 GLY A N   1 
ATOM   774  C CA  . GLY A 1 99  ? 11.383  9.100   21.913  1.00 34.71  ? 431 GLY A CA  1 
ATOM   775  C C   . GLY A 1 99  ? 10.904  7.878   22.668  1.00 42.61  ? 431 GLY A C   1 
ATOM   776  O O   . GLY A 1 99  ? 10.465  6.894   22.070  1.00 39.99  ? 431 GLY A O   1 
ATOM   777  N N   . CYS A 1 100 ? 10.992  7.961   23.991  1.00 42.38  ? 432 CYS A N   1 
ATOM   778  C CA  . CYS A 1 100 ? 10.646  6.857   24.871  1.00 33.69  ? 432 CYS A CA  1 
ATOM   779  C C   . CYS A 1 100 ? 9.607   7.309   25.886  1.00 38.01  ? 432 CYS A C   1 
ATOM   780  O O   . CYS A 1 100 ? 9.639   8.449   26.359  1.00 38.98  ? 432 CYS A O   1 
ATOM   781  C CB  . CYS A 1 100 ? 11.889  6.321   25.592  1.00 30.70  ? 432 CYS A CB  1 
ATOM   782  S SG  . CYS A 1 100 ? 13.138  5.590   24.501  1.00 52.78  ? 432 CYS A SG  1 
ATOM   783  N N   . VAL A 1 101 ? 8.681   6.412   26.211  1.00 30.08  ? 433 VAL A N   1 
ATOM   784  C CA  . VAL A 1 101 ? 7.703   6.629   27.270  1.00 31.96  ? 433 VAL A CA  1 
ATOM   785  C C   . VAL A 1 101 ? 8.038   5.676   28.408  1.00 35.90  ? 433 VAL A C   1 
ATOM   786  O O   . VAL A 1 101 ? 7.983   4.451   28.237  1.00 41.37  ? 433 VAL A O   1 
ATOM   787  C CB  . VAL A 1 101 ? 6.266   6.418   26.772  1.00 33.96  ? 433 VAL A CB  1 
ATOM   788  C CG1 . VAL A 1 101 ? 5.288   6.524   27.932  1.00 21.86  ? 433 VAL A CG1 1 
ATOM   789  C CG2 . VAL A 1 101 ? 5.929   7.429   25.683  1.00 28.41  ? 433 VAL A CG2 1 
ATOM   790  N N   . ILE A 1 102 ? 8.382   6.231   29.567  1.00 35.00  ? 434 ILE A N   1 
ATOM   791  C CA  . ILE A 1 102 ? 8.818   5.450   30.719  1.00 36.17  ? 434 ILE A CA  1 
ATOM   792  C C   . ILE A 1 102 ? 7.831   5.670   31.855  1.00 39.79  ? 434 ILE A C   1 
ATOM   793  O O   . ILE A 1 102 ? 7.503   6.816   32.188  1.00 40.82  ? 434 ILE A O   1 
ATOM   794  C CB  . ILE A 1 102 ? 10.244  5.826   31.157  1.00 34.49  ? 434 ILE A CB  1 
ATOM   795  C CG1 . ILE A 1 102 ? 11.218  5.685   29.985  1.00 33.25  ? 434 ILE A CG1 1 
ATOM   796  C CG2 . ILE A 1 102 ? 10.685  4.952   32.316  1.00 30.01  ? 434 ILE A CG2 1 
ATOM   797  C CD1 . ILE A 1 102 ? 12.611  6.201   30.277  1.00 32.31  ? 434 ILE A CD1 1 
ATOM   798  N N   . ALA A 1 103 ? 7.356   4.575   32.444  1.00 33.78  ? 435 ALA A N   1 
ATOM   799  C CA  . ALA A 1 103 ? 6.424   4.648   33.558  1.00 41.31  ? 435 ALA A CA  1 
ATOM   800  C C   . ALA A 1 103 ? 6.780   3.587   34.590  1.00 47.29  ? 435 ALA A C   1 
ATOM   801  O O   . ALA A 1 103 ? 7.346   2.541   34.261  1.00 41.16  ? 435 ALA A O   1 
ATOM   802  C CB  . ALA A 1 103 ? 4.973   4.474   33.091  1.00 29.92  ? 435 ALA A CB  1 
ATOM   803  N N   . TRP A 1 104 ? 6.451   3.876   35.847  1.00 38.79  ? 436 TRP A N   1 
ATOM   804  C CA  . TRP A 1 104 ? 6.673   2.935   36.932  1.00 33.56  ? 436 TRP A CA  1 
ATOM   805  C C   . TRP A 1 104 ? 5.628   3.181   38.009  1.00 40.77  ? 436 TRP A C   1 
ATOM   806  O O   . TRP A 1 104 ? 5.144   4.304   38.179  1.00 35.24  ? 436 TRP A O   1 
ATOM   807  C CB  . TRP A 1 104 ? 8.091   3.059   37.511  1.00 33.74  ? 436 TRP A CB  1 
ATOM   808  C CG  . TRP A 1 104 ? 8.358   4.355   38.215  1.00 41.36  ? 436 TRP A CG  1 
ATOM   809  C CD1 . TRP A 1 104 ? 8.085   4.651   39.520  1.00 44.17  ? 436 TRP A CD1 1 
ATOM   810  C CD2 . TRP A 1 104 ? 8.960   5.530   37.656  1.00 45.29  ? 436 TRP A CD2 1 
ATOM   811  N NE1 . TRP A 1 104 ? 8.473   5.937   39.806  1.00 42.42  ? 436 TRP A NE1 1 
ATOM   812  C CE2 . TRP A 1 104 ? 9.014   6.498   38.680  1.00 41.13  ? 436 TRP A CE2 1 
ATOM   813  C CE3 . TRP A 1 104 ? 9.457   5.857   36.391  1.00 36.82  ? 436 TRP A CE3 1 
ATOM   814  C CZ2 . TRP A 1 104 ? 9.545   7.770   38.476  1.00 45.12  ? 436 TRP A CZ2 1 
ATOM   815  C CZ3 . TRP A 1 104 ? 9.982   7.120   36.191  1.00 37.92  ? 436 TRP A CZ3 1 
ATOM   816  C CH2 . TRP A 1 104 ? 10.022  8.061   37.229  1.00 51.92  ? 436 TRP A CH2 1 
ATOM   817  N N   . ASN A 1 105 ? 5.279   2.116   38.728  1.00 39.83  ? 437 ASN A N   1 
ATOM   818  C CA  . ASN A 1 105 ? 4.287   2.223   39.789  1.00 33.70  ? 437 ASN A CA  1 
ATOM   819  C C   . ASN A 1 105 ? 4.844   3.055   40.935  1.00 37.64  ? 437 ASN A C   1 
ATOM   820  O O   . ASN A 1 105 ? 5.972   2.833   41.388  1.00 44.12  ? 437 ASN A O   1 
ATOM   821  C CB  . ASN A 1 105 ? 3.887   0.834   40.286  1.00 33.28  ? 437 ASN A CB  1 
ATOM   822  C CG  . ASN A 1 105 ? 2.762   0.878   41.307  1.00 34.92  ? 437 ASN A CG  1 
ATOM   823  O OD1 . ASN A 1 105 ? 2.973   1.235   42.466  1.00 42.73  ? 437 ASN A OD1 1 
ATOM   824  N ND2 . ASN A 1 105 ? 1.560   0.505   40.881  1.00 38.07  ? 437 ASN A ND2 1 
ATOM   825  N N   . SER A 1 106 ? 4.052   4.012   41.405  1.00 34.21  ? 438 SER A N   1 
ATOM   826  C CA  . SER A 1 106 ? 4.462   4.910   42.476  1.00 48.32  ? 438 SER A CA  1 
ATOM   827  C C   . SER A 1 106 ? 3.414   4.943   43.577  1.00 53.48  ? 438 SER A C   1 
ATOM   828  O O   . SER A 1 106 ? 3.099   6.002   44.128  1.00 59.46  ? 438 SER A O   1 
ATOM   829  C CB  . SER A 1 106 ? 4.727   6.316   41.941  1.00 41.30  ? 438 SER A CB  1 
ATOM   830  O OG  . SER A 1 106 ? 3.528   6.938   41.510  1.00 50.16  ? 438 SER A OG  1 
ATOM   831  N N   . ASN A 1 107 ? 2.855   3.777   43.913  1.00 46.79  ? 439 ASN A N   1 
ATOM   832  C CA  . ASN A 1 107 ? 1.854   3.722   44.973  1.00 45.51  ? 439 ASN A CA  1 
ATOM   833  C C   . ASN A 1 107 ? 2.457   4.063   46.331  1.00 52.08  ? 439 ASN A C   1 
ATOM   834  O O   . ASN A 1 107 ? 1.767   4.623   47.189  1.00 54.66  ? 439 ASN A O   1 
ATOM   835  C CB  . ASN A 1 107 ? 1.201   2.338   45.010  1.00 40.68  ? 439 ASN A CB  1 
ATOM   836  C CG  . ASN A 1 107 ? -0.172  2.354   45.663  1.00 56.20  ? 439 ASN A CG  1 
ATOM   837  O OD1 . ASN A 1 107 ? -1.032  3.162   45.309  1.00 59.56  ? 439 ASN A OD1 1 
ATOM   838  N ND2 . ASN A 1 107 ? -0.382  1.463   46.626  1.00 63.11  ? 439 ASN A ND2 1 
ATOM   839  N N   . ASN A 1 108 ? 3.738   3.742   46.540  1.00 56.34  ? 440 ASN A N   1 
ATOM   840  C CA  . ASN A 1 108 ? 4.381   4.020   47.822  1.00 53.31  ? 440 ASN A CA  1 
ATOM   841  C C   . ASN A 1 108 ? 4.505   5.516   48.079  1.00 51.93  ? 440 ASN A C   1 
ATOM   842  O O   . ASN A 1 108 ? 4.306   5.975   49.210  1.00 49.09  ? 440 ASN A O   1 
ATOM   843  C CB  . ASN A 1 108 ? 5.758   3.361   47.872  1.00 60.89  ? 440 ASN A CB  1 
ATOM   844  C CG  . ASN A 1 108 ? 5.679   1.850   47.845  1.00 76.17  ? 440 ASN A CG  1 
ATOM   845  O OD1 . ASN A 1 108 ? 4.812   1.252   48.482  1.00 64.30  ? 440 ASN A OD1 1 
ATOM   846  N ND2 . ASN A 1 108 ? 6.584   1.223   47.102  1.00 78.80  ? 440 ASN A ND2 1 
ATOM   847  N N   . LEU A 1 109 ? 4.832   6.292   47.047  1.00 57.32  ? 441 LEU A N   1 
ATOM   848  C CA  . LEU A 1 109 ? 5.131   7.710   47.204  1.00 47.31  ? 441 LEU A CA  1 
ATOM   849  C C   . LEU A 1 109 ? 3.939   8.626   46.971  1.00 47.71  ? 441 LEU A C   1 
ATOM   850  O O   . LEU A 1 109 ? 3.915   9.733   47.519  1.00 55.00  ? 441 LEU A O   1 
ATOM   851  C CB  . LEU A 1 109 ? 6.252   8.120   46.244  1.00 42.24  ? 441 LEU A CB  1 
ATOM   852  C CG  . LEU A 1 109 ? 7.640   7.566   46.548  1.00 58.64  ? 441 LEU A CG  1 
ATOM   853  C CD1 . LEU A 1 109 ? 8.571   7.810   45.372  1.00 48.80  ? 441 LEU A CD1 1 
ATOM   854  C CD2 . LEU A 1 109 ? 8.190   8.200   47.818  1.00 65.24  ? 441 LEU A CD2 1 
ATOM   855  N N   . ASP A 1 110 ? 2.952   8.207   46.178  1.00 54.26  ? 442 ASP A N   1 
ATOM   856  C CA  . ASP A 1 110 ? 1.897   9.111   45.742  1.00 56.73  ? 442 ASP A CA  1 
ATOM   857  C C   . ASP A 1 110 ? 0.505   8.763   46.251  1.00 51.12  ? 442 ASP A C   1 
ATOM   858  O O   . ASP A 1 110 ? -0.416  9.564   46.056  1.00 65.43  ? 442 ASP A O   1 
ATOM   859  C CB  . ASP A 1 110 ? 1.860   9.183   44.207  1.00 48.44  ? 442 ASP A CB  1 
ATOM   860  C CG  . ASP A 1 110 ? 3.124   9.785   43.621  1.00 52.25  ? 442 ASP A CG  1 
ATOM   861  O OD1 . ASP A 1 110 ? 3.630   10.775  44.189  1.00 51.08  ? 442 ASP A OD1 1 
ATOM   862  O OD2 . ASP A 1 110 ? 3.617   9.265   42.598  1.00 57.43  ? 442 ASP A OD2 1 
ATOM   863  N N   . SER A 1 111 ? 0.314   7.616   46.893  1.00 48.62  ? 443 SER A N   1 
ATOM   864  C CA  . SER A 1 111 ? -0.990  7.234   47.423  1.00 61.99  ? 443 SER A CA  1 
ATOM   865  C C   . SER A 1 111 ? -0.967  7.367   48.939  1.00 69.43  ? 443 SER A C   1 
ATOM   866  O O   . SER A 1 111 ? -0.119  6.766   49.607  1.00 75.74  ? 443 SER A O   1 
ATOM   867  C CB  . SER A 1 111 ? -1.362  5.810   47.007  1.00 62.22  ? 443 SER A CB  1 
ATOM   868  O OG  . SER A 1 111 ? -0.446  4.865   47.528  1.00 72.82  ? 443 SER A OG  1 
ATOM   869  N N   . LYS A 1 112 ? -1.893  8.154   49.476  1.00 74.85  ? 444 LYS A N   1 
ATOM   870  C CA  . LYS A 1 112 ? -2.000  8.375   50.908  1.00 83.21  ? 444 LYS A CA  1 
ATOM   871  C C   . LYS A 1 112 ? -3.206  7.626   51.457  1.00 90.33  ? 444 LYS A C   1 
ATOM   872  O O   . LYS A 1 112 ? -4.176  7.365   50.740  1.00 82.28  ? 444 LYS A O   1 
ATOM   873  C CB  . LYS A 1 112 ? -2.133  9.865   51.237  1.00 71.88  ? 444 LYS A CB  1 
ATOM   874  C CG  . LYS A 1 112 ? -1.295  10.789  50.367  1.00 76.77  ? 444 LYS A CG  1 
ATOM   875  C CD  . LYS A 1 112 ? 0.196   10.570  50.567  1.00 72.11  ? 444 LYS A CD  1 
ATOM   876  C CE  . LYS A 1 112 ? 1.000   11.747  50.024  1.00 77.63  ? 444 LYS A CE  1 
ATOM   877  N NZ  . LYS A 1 112 ? 0.677   13.037  50.707  1.00 58.94  ? 444 LYS A NZ  1 
ATOM   878  N N   . VAL A 1 113 ? -3.132  7.273   52.742  1.00 97.79  ? 445 VAL A N   1 
ATOM   879  C CA  . VAL A 1 113 ? -4.288  6.692   53.410  1.00 98.44  ? 445 VAL A CA  1 
ATOM   880  C C   . VAL A 1 113 ? -5.386  7.739   53.483  1.00 92.33  ? 445 VAL A C   1 
ATOM   881  O O   . VAL A 1 113 ? -5.157  8.882   53.898  1.00 83.68  ? 445 VAL A O   1 
ATOM   882  C CB  . VAL A 1 113 ? -3.906  6.163   54.801  1.00 94.59  ? 445 VAL A CB  1 
ATOM   883  C CG1 . VAL A 1 113 ? -3.211  4.815   54.676  1.00 85.16  ? 445 VAL A CG1 1 
ATOM   884  C CG2 . VAL A 1 113 ? -3.019  7.167   55.531  1.00 71.16  ? 445 VAL A CG2 1 
ATOM   885  N N   . GLY A 1 114 ? -6.587  7.358   53.064  1.00 75.12  ? 446 GLY A N   1 
ATOM   886  C CA  . GLY A 1 114 ? -7.617  8.352   52.870  1.00 74.76  ? 446 GLY A CA  1 
ATOM   887  C C   . GLY A 1 114 ? -7.412  9.228   51.656  1.00 86.32  ? 446 GLY A C   1 
ATOM   888  O O   . GLY A 1 114 ? -8.022  10.293  51.572  1.00 84.13  ? 446 GLY A O   1 
ATOM   889  N N   . GLY A 1 115 ? -6.556  8.815   50.722  1.00 90.28  ? 447 GLY A N   1 
ATOM   890  C CA  . GLY A 1 115 ? -6.429  9.455   49.428  1.00 87.81  ? 447 GLY A CA  1 
ATOM   891  C C   . GLY A 1 115 ? -5.398  10.574  49.405  1.00 90.32  ? 447 GLY A C   1 
ATOM   892  O O   . GLY A 1 115 ? -4.951  11.076  50.433  1.00 99.25  ? 447 GLY A O   1 
ATOM   893  N N   . ASN A 1 116 ? -5.015  10.964  48.188  1.00 78.07  ? 448 ASN A N   1 
ATOM   894  C CA  . ASN A 1 116 ? -4.023  12.018  47.987  1.00 74.81  ? 448 ASN A CA  1 
ATOM   895  C C   . ASN A 1 116 ? -4.694  13.349  47.659  1.00 78.49  ? 448 ASN A C   1 
ATOM   896  O O   . ASN A 1 116 ? -4.449  14.354  48.333  1.00 91.93  ? 448 ASN A O   1 
ATOM   897  C CB  . ASN A 1 116 ? -3.022  11.597  46.889  1.00 63.92  ? 448 ASN A CB  1 
ATOM   898  C CG  . ASN A 1 116 ? -1.786  12.494  46.827  1.00 58.35  ? 448 ASN A CG  1 
ATOM   899  O OD1 . ASN A 1 116 ? -1.845  13.689  47.124  1.00 62.37  ? 448 ASN A OD1 1 
ATOM   900  N ND2 . ASN A 1 116 ? -0.662  11.916  46.416  1.00 60.38  ? 448 ASN A ND2 1 
ATOM   901  N N   . TYR A 1 117 ? -5.543  13.364  46.631  1.00 61.97  ? 449 TYR A N   1 
ATOM   902  C CA  . TYR A 1 117 ? -6.359  14.515  46.242  1.00 66.09  ? 449 TYR A CA  1 
ATOM   903  C C   . TYR A 1 117 ? -5.524  15.707  45.800  1.00 59.29  ? 449 TYR A C   1 
ATOM   904  O O   . TYR A 1 117 ? -6.041  16.824  45.703  1.00 56.59  ? 449 TYR A O   1 
ATOM   905  C CB  . TYR A 1 117 ? -7.318  14.943  47.360  1.00 69.81  ? 449 TYR A CB  1 
ATOM   906  C CG  . TYR A 1 117 ? -8.233  13.843  47.838  1.00 83.51  ? 449 TYR A CG  1 
ATOM   907  C CD1 . TYR A 1 117 ? -7.805  12.935  48.794  1.00 93.35  ? 449 TYR A CD1 1 
ATOM   908  C CD2 . TYR A 1 117 ? -9.523  13.710  47.336  1.00 67.03  ? 449 TYR A CD2 1 
ATOM   909  C CE1 . TYR A 1 117 ? -8.628  11.930  49.235  1.00 91.37  ? 449 TYR A CE1 1 
ATOM   910  C CE2 . TYR A 1 117 ? -10.358 12.697  47.777  1.00 71.40  ? 449 TYR A CE2 1 
ATOM   911  C CZ  . TYR A 1 117 ? -9.900  11.808  48.728  1.00 91.68  ? 449 TYR A CZ  1 
ATOM   912  O OH  . TYR A 1 117 ? -10.710 10.792  49.183  1.00 98.51  ? 449 TYR A OH  1 
ATOM   913  N N   . ASN A 1 118 ? -4.239  15.501  45.527  1.00 61.99  ? 450 ASN A N   1 
ATOM   914  C CA  . ASN A 1 118 ? -3.388  16.570  45.024  1.00 52.76  ? 450 ASN A CA  1 
ATOM   915  C C   . ASN A 1 118 ? -3.049  16.432  43.552  1.00 56.58  ? 450 ASN A C   1 
ATOM   916  O O   . ASN A 1 118 ? -2.765  17.439  42.900  1.00 58.55  ? 450 ASN A O   1 
ATOM   917  C CB  . ASN A 1 118 ? -2.084  16.645  45.827  1.00 62.58  ? 450 ASN A CB  1 
ATOM   918  C CG  . ASN A 1 118 ? -2.210  17.510  47.065  1.00 67.29  ? 450 ASN A CG  1 
ATOM   919  O OD1 . ASN A 1 118 ? -3.300  17.673  47.615  1.00 75.69  ? 450 ASN A OD1 1 
ATOM   920  N ND2 . ASN A 1 118 ? -1.094  18.078  47.505  1.00 65.72  ? 450 ASN A ND2 1 
ATOM   921  N N   . TYR A 1 119 ? -3.068  15.215  43.015  1.00 53.45  ? 451 TYR A N   1 
ATOM   922  C CA  . TYR A 1 119 ? -2.853  15.017  41.591  1.00 43.84  ? 451 TYR A CA  1 
ATOM   923  C C   . TYR A 1 119 ? -4.170  15.206  40.850  1.00 44.16  ? 451 TYR A C   1 
ATOM   924  O O   . TYR A 1 119 ? -5.192  14.617  41.217  1.00 43.16  ? 451 TYR A O   1 
ATOM   925  C CB  . TYR A 1 119 ? -2.268  13.631  41.324  1.00 39.18  ? 451 TYR A CB  1 
ATOM   926  C CG  . TYR A 1 119 ? -0.814  13.499  41.731  1.00 39.38  ? 451 TYR A CG  1 
ATOM   927  C CD1 . TYR A 1 119 ? 0.197   14.031  40.941  1.00 38.20  ? 451 TYR A CD1 1 
ATOM   928  C CD2 . TYR A 1 119 ? -0.452  12.844  42.902  1.00 43.62  ? 451 TYR A CD2 1 
ATOM   929  C CE1 . TYR A 1 119 ? 1.525   13.917  41.303  1.00 40.12  ? 451 TYR A CE1 1 
ATOM   930  C CE2 . TYR A 1 119 ? 0.879   12.724  43.273  1.00 48.50  ? 451 TYR A CE2 1 
ATOM   931  C CZ  . TYR A 1 119 ? 1.863   13.265  42.467  1.00 46.92  ? 451 TYR A CZ  1 
ATOM   932  O OH  . TYR A 1 119 ? 3.190   13.157  42.818  1.00 57.59  ? 451 TYR A OH  1 
ATOM   933  N N   . LEU A 1 120 ? -4.147  16.040  39.816  1.00 45.70  ? 452 LEU A N   1 
ATOM   934  C CA  . LEU A 1 120 ? -5.346  16.429  39.096  1.00 37.50  ? 452 LEU A CA  1 
ATOM   935  C C   . LEU A 1 120 ? -5.203  16.113  37.615  1.00 42.87  ? 452 LEU A C   1 
ATOM   936  O O   . LEU A 1 120 ? -4.097  15.938  37.096  1.00 50.65  ? 452 LEU A O   1 
ATOM   937  C CB  . LEU A 1 120 ? -5.634  17.924  39.270  1.00 40.04  ? 452 LEU A CB  1 
ATOM   938  C CG  . LEU A 1 120 ? -5.624  18.465  40.698  1.00 36.09  ? 452 LEU A CG  1 
ATOM   939  C CD1 . LEU A 1 120 ? -5.834  19.966  40.669  1.00 30.39  ? 452 LEU A CD1 1 
ATOM   940  C CD2 . LEU A 1 120 ? -6.681  17.780  41.553  1.00 38.96  ? 452 LEU A CD2 1 
ATOM   941  N N   . TYR A 1 121 ? -6.346  16.042  36.939  1.00 36.06  ? 453 TYR A N   1 
ATOM   942  C CA  . TYR A 1 121 ? -6.385  15.910  35.492  1.00 35.10  ? 453 TYR A CA  1 
ATOM   943  C C   . TYR A 1 121 ? -7.535  16.751  34.956  1.00 41.70  ? 453 TYR A C   1 
ATOM   944  O O   . TYR A 1 121 ? -8.518  17.003  35.659  1.00 36.19  ? 453 TYR A O   1 
ATOM   945  C CB  . TYR A 1 121 ? -6.541  14.446  35.056  1.00 33.73  ? 453 TYR A CB  1 
ATOM   946  C CG  . TYR A 1 121 ? -7.858  13.820  35.447  1.00 36.72  ? 453 TYR A CG  1 
ATOM   947  C CD1 . TYR A 1 121 ? -8.070  13.348  36.735  1.00 44.26  ? 453 TYR A CD1 1 
ATOM   948  C CD2 . TYR A 1 121 ? -8.888  13.695  34.525  1.00 31.02  ? 453 TYR A CD2 1 
ATOM   949  C CE1 . TYR A 1 121 ? -9.271  12.776  37.097  1.00 41.44  ? 453 TYR A CE1 1 
ATOM   950  C CE2 . TYR A 1 121 ? -10.094 13.124  34.877  1.00 32.50  ? 453 TYR A CE2 1 
ATOM   951  C CZ  . TYR A 1 121 ? -10.279 12.666  36.164  1.00 39.04  ? 453 TYR A CZ  1 
ATOM   952  O OH  . TYR A 1 121 ? -11.475 12.094  36.525  1.00 52.64  ? 453 TYR A OH  1 
ATOM   953  N N   . ARG A 1 122 ? -7.400  17.193  33.708  1.00 34.05  ? 454 ARG A N   1 
ATOM   954  C CA  . ARG A 1 122 ? -8.455  17.964  33.065  1.00 32.73  ? 454 ARG A CA  1 
ATOM   955  C C   . ARG A 1 122 ? -9.561  17.032  32.589  1.00 39.56  ? 454 ARG A C   1 
ATOM   956  O O   . ARG A 1 122 ? -9.302  16.063  31.868  1.00 41.94  ? 454 ARG A O   1 
ATOM   957  C CB  . ARG A 1 122 ? -7.902  18.767  31.889  1.00 37.13  ? 454 ARG A CB  1 
ATOM   958  C CG  . ARG A 1 122 ? -8.940  19.637  31.199  1.00 36.57  ? 454 ARG A CG  1 
ATOM   959  C CD  . ARG A 1 122 ? -8.280  20.591  30.226  1.00 39.05  ? 454 ARG A CD  1 
ATOM   960  N NE  . ARG A 1 122 ? -7.354  21.483  30.911  1.00 34.91  ? 454 ARG A NE  1 
ATOM   961  C CZ  . ARG A 1 122 ? -7.718  22.594  31.534  1.00 28.28  ? 454 ARG A CZ  1 
ATOM   962  N NH1 . ARG A 1 122 ? -8.984  22.977  31.581  1.00 30.49  ? 454 ARG A NH1 1 
ATOM   963  N NH2 . ARG A 1 122 ? -6.790  23.339  32.124  1.00 37.18  ? 454 ARG A NH2 1 
ATOM   964  N N   . LEU A 1 123 ? -10.796 17.332  32.987  1.00 33.25  ? 455 LEU A N   1 
ATOM   965  C CA  . LEU A 1 123 ? -11.939 16.496  32.647  1.00 31.04  ? 455 LEU A CA  1 
ATOM   966  C C   . LEU A 1 123 ? -12.791 17.065  31.521  1.00 39.88  ? 455 LEU A C   1 
ATOM   967  O O   . LEU A 1 123 ? -13.378 16.293  30.757  1.00 41.23  ? 455 LEU A O   1 
ATOM   968  C CB  . LEU A 1 123 ? -12.817 16.281  33.887  1.00 34.83  ? 455 LEU A CB  1 
ATOM   969  C CG  . LEU A 1 123 ? -14.057 15.396  33.752  1.00 30.40  ? 455 LEU A CG  1 
ATOM   970  C CD1 . LEU A 1 123 ? -13.675 14.026  33.227  1.00 43.56  ? 455 LEU A CD1 1 
ATOM   971  C CD2 . LEU A 1 123 ? -14.772 15.273  35.087  1.00 26.23  ? 455 LEU A CD2 1 
ATOM   972  N N   . PHE A 1 124 ? -12.869 18.388  31.391  1.00 37.71  ? 456 PHE A N   1 
ATOM   973  C CA  . PHE A 1 124 ? -13.713 19.028  30.391  1.00 35.56  ? 456 PHE A CA  1 
ATOM   974  C C   . PHE A 1 124 ? -12.869 19.928  29.502  1.00 35.74  ? 456 PHE A C   1 
ATOM   975  O O   . PHE A 1 124 ? -12.046 20.703  29.998  1.00 40.94  ? 456 PHE A O   1 
ATOM   976  C CB  . PHE A 1 124 ? -14.829 19.842  31.050  1.00 28.67  ? 456 PHE A CB  1 
ATOM   977  C CG  . PHE A 1 124 ? -15.839 19.007  31.780  1.00 40.69  ? 456 PHE A CG  1 
ATOM   978  C CD1 . PHE A 1 124 ? -16.828 18.329  31.085  1.00 42.74  ? 456 PHE A CD1 1 
ATOM   979  C CD2 . PHE A 1 124 ? -15.806 18.906  33.162  1.00 36.34  ? 456 PHE A CD2 1 
ATOM   980  C CE1 . PHE A 1 124 ? -17.760 17.560  31.754  1.00 36.31  ? 456 PHE A CE1 1 
ATOM   981  C CE2 . PHE A 1 124 ? -16.739 18.139  33.837  1.00 29.36  ? 456 PHE A CE2 1 
ATOM   982  C CZ  . PHE A 1 124 ? -17.716 17.466  33.132  1.00 41.13  ? 456 PHE A CZ  1 
ATOM   983  N N   . ARG A 1 125 ? -13.080 19.821  28.191  1.00 34.21  ? 457 ARG A N   1 
ATOM   984  C CA  . ARG A 1 125 ? -12.429 20.699  27.227  1.00 30.03  ? 457 ARG A CA  1 
ATOM   985  C C   . ARG A 1 125 ? -13.165 20.557  25.903  1.00 36.37  ? 457 ARG A C   1 
ATOM   986  O O   . ARG A 1 125 ? -13.489 19.439  25.494  1.00 46.84  ? 457 ARG A O   1 
ATOM   987  C CB  . ARG A 1 125 ? -10.942 20.354  27.072  1.00 30.64  ? 457 ARG A CB  1 
ATOM   988  C CG  . ARG A 1 125 ? -10.106 21.464  26.445  1.00 32.80  ? 457 ARG A CG  1 
ATOM   989  C CD  . ARG A 1 125 ? -8.618  21.143  26.502  1.00 41.00  ? 457 ARG A CD  1 
ATOM   990  N NE  . ARG A 1 125 ? -7.790  22.297  26.170  1.00 34.84  ? 457 ARG A NE  1 
ATOM   991  C CZ  . ARG A 1 125 ? -7.427  22.630  24.939  1.00 30.96  ? 457 ARG A CZ  1 
ATOM   992  N NH1 . ARG A 1 125 ? -7.806  21.919  23.891  1.00 44.67  ? 457 ARG A NH1 1 
ATOM   993  N NH2 . ARG A 1 125 ? -6.664  23.703  24.755  1.00 29.95  ? 457 ARG A NH2 1 
ATOM   994  N N   . LYS A 1 126 ? -13.443 21.684  25.246  1.00 32.55  ? 458 LYS A N   1 
ATOM   995  C CA  . LYS A 1 126 ? -14.257 21.662  24.038  1.00 38.69  ? 458 LYS A CA  1 
ATOM   996  C C   . LYS A 1 126 ? -13.495 21.187  22.809  1.00 40.33  ? 458 LYS A C   1 
ATOM   997  O O   . LYS A 1 126 ? -14.126 20.897  21.787  1.00 45.99  ? 458 LYS A O   1 
ATOM   998  C CB  . LYS A 1 126 ? -14.848 23.052  23.783  1.00 47.69  ? 458 LYS A CB  1 
ATOM   999  C CG  . LYS A 1 126 ? -15.771 23.520  24.902  1.00 38.63  ? 458 LYS A CG  1 
ATOM   1000 C CD  . LYS A 1 126 ? -16.375 24.890  24.637  1.00 49.14  ? 458 LYS A CD  1 
ATOM   1001 C CE  . LYS A 1 126 ? -17.209 25.358  25.827  1.00 41.27  ? 458 LYS A CE  1 
ATOM   1002 N NZ  . LYS A 1 126 ? -18.016 26.570  25.504  1.00 55.91  ? 458 LYS A NZ  1 
ATOM   1003 N N   . SER A 1 127 ? -12.169 21.097  22.879  1.00 38.20  ? 459 SER A N   1 
ATOM   1004 C CA  . SER A 1 127 ? -11.377 20.599  21.766  1.00 33.68  ? 459 SER A CA  1 
ATOM   1005 C C   . SER A 1 127 ? -10.167 19.866  22.320  1.00 40.15  ? 459 SER A C   1 
ATOM   1006 O O   . SER A 1 127 ? -9.708  20.147  23.431  1.00 36.79  ? 459 SER A O   1 
ATOM   1007 C CB  . SER A 1 127 ? -10.935 21.731  20.832  1.00 30.56  ? 459 SER A CB  1 
ATOM   1008 O OG  . SER A 1 127 ? -10.138 22.678  21.521  1.00 61.75  ? 459 SER A OG  1 
ATOM   1009 N N   . ASN A 1 128 ? -9.660  18.920  21.534  1.00 38.71  ? 460 ASN A N   1 
ATOM   1010 C CA  . ASN A 1 128 ? -8.508  18.137  21.951  1.00 43.30  ? 460 ASN A CA  1 
ATOM   1011 C C   . ASN A 1 128 ? -7.229  18.967  21.873  1.00 39.54  ? 460 ASN A C   1 
ATOM   1012 O O   . ASN A 1 128 ? -7.088  19.862  21.035  1.00 38.89  ? 460 ASN A O   1 
ATOM   1013 C CB  . ASN A 1 128 ? -8.375  16.879  21.090  1.00 41.94  ? 460 ASN A CB  1 
ATOM   1014 C CG  . ASN A 1 128 ? -9.555  15.935  21.244  1.00 46.04  ? 460 ASN A CG  1 
ATOM   1015 O OD1 . ASN A 1 128 ? -10.351 16.056  22.178  1.00 48.01  ? 460 ASN A OD1 1 
ATOM   1016 N ND2 . ASN A 1 128 ? -9.666  14.978  20.330  1.00 47.00  ? 460 ASN A ND2 1 
ATOM   1017 N N   . LEU A 1 129 ? -6.293  18.657  22.766  1.00 39.83  ? 461 LEU A N   1 
ATOM   1018 C CA  . LEU A 1 129 ? -5.004  19.330  22.777  1.00 32.97  ? 461 LEU A CA  1 
ATOM   1019 C C   . LEU A 1 129 ? -4.194  18.982  21.536  1.00 35.55  ? 461 LEU A C   1 
ATOM   1020 O O   . LEU A 1 129 ? -4.223  17.847  21.054  1.00 43.67  ? 461 LEU A O   1 
ATOM   1021 C CB  . LEU A 1 129 ? -4.212  18.937  24.024  1.00 33.84  ? 461 LEU A CB  1 
ATOM   1022 C CG  . LEU A 1 129 ? -4.485  19.695  25.318  1.00 32.90  ? 461 LEU A CG  1 
ATOM   1023 C CD1 . LEU A 1 129 ? -3.584  19.156  26.410  1.00 26.88  ? 461 LEU A CD1 1 
ATOM   1024 C CD2 . LEU A 1 129 ? -4.252  21.179  25.107  1.00 45.84  ? 461 LEU A CD2 1 
ATOM   1025 N N   . LYS A 1 130 ? -3.472  19.972  21.017  1.00 40.27  ? 462 LYS A N   1 
ATOM   1026 C CA  . LYS A 1 130 ? -2.440  19.708  20.031  1.00 43.91  ? 462 LYS A CA  1 
ATOM   1027 C C   . LYS A 1 130 ? -1.237  19.065  20.722  1.00 41.29  ? 462 LYS A C   1 
ATOM   1028 O O   . LYS A 1 130 ? -1.073  19.192  21.938  1.00 41.02  ? 462 LYS A O   1 
ATOM   1029 C CB  . LYS A 1 130 ? -2.043  21.001  19.319  1.00 39.98  ? 462 LYS A CB  1 
ATOM   1030 C CG  . LYS A 1 130 ? -3.097  21.507  18.338  1.00 51.22  ? 462 LYS A CG  1 
ATOM   1031 C CD  . LYS A 1 130 ? -2.905  22.979  17.980  1.00 65.84  ? 462 LYS A CD  1 
ATOM   1032 C CE  . LYS A 1 130 ? -1.618  23.225  17.203  1.00 81.14  ? 462 LYS A CE  1 
ATOM   1033 N NZ  . LYS A 1 130 ? -1.459  24.661  16.825  1.00 64.07  ? 462 LYS A NZ  1 
ATOM   1034 N N   . PRO A 1 131 ? -0.400  18.343  19.976  1.00 40.19  ? 463 PRO A N   1 
ATOM   1035 C CA  . PRO A 1 131 ? 0.726   17.643  20.611  1.00 35.74  ? 463 PRO A CA  1 
ATOM   1036 C C   . PRO A 1 131 ? 1.648   18.600  21.352  1.00 29.62  ? 463 PRO A C   1 
ATOM   1037 O O   . PRO A 1 131 ? 1.927   19.708  20.890  1.00 35.57  ? 463 PRO A O   1 
ATOM   1038 C CB  . PRO A 1 131 ? 1.440   16.978  19.429  1.00 37.63  ? 463 PRO A CB  1 
ATOM   1039 C CG  . PRO A 1 131 ? 0.372   16.803  18.405  1.00 41.14  ? 463 PRO A CG  1 
ATOM   1040 C CD  . PRO A 1 131 ? -0.522  18.002  18.547  1.00 37.60  ? 463 PRO A CD  1 
ATOM   1041 N N   . PHE A 1 132 ? 2.122   18.151  22.516  1.00 34.90  ? 464 PHE A N   1 
ATOM   1042 C CA  . PHE A 1 132 ? 3.038   18.926  23.357  1.00 30.56  ? 464 PHE A CA  1 
ATOM   1043 C C   . PHE A 1 132 ? 2.458   20.292  23.719  1.00 33.99  ? 464 PHE A C   1 
ATOM   1044 O O   . PHE A 1 132 ? 3.149   21.311  23.675  1.00 49.52  ? 464 PHE A O   1 
ATOM   1045 C CB  . PHE A 1 132 ? 4.404   19.082  22.684  1.00 38.93  ? 464 PHE A CB  1 
ATOM   1046 C CG  . PHE A 1 132 ? 5.175   17.802  22.580  1.00 38.60  ? 464 PHE A CG  1 
ATOM   1047 C CD1 . PHE A 1 132 ? 5.079   16.840  23.571  1.00 34.43  ? 464 PHE A CD1 1 
ATOM   1048 C CD2 . PHE A 1 132 ? 5.993   17.556  21.489  1.00 42.91  ? 464 PHE A CD2 1 
ATOM   1049 C CE1 . PHE A 1 132 ? 5.788   15.659  23.480  1.00 31.54  ? 464 PHE A CE1 1 
ATOM   1050 C CE2 . PHE A 1 132 ? 6.704   16.374  21.391  1.00 49.67  ? 464 PHE A CE2 1 
ATOM   1051 C CZ  . PHE A 1 132 ? 6.600   15.424  22.388  1.00 38.01  ? 464 PHE A CZ  1 
ATOM   1052 N N   . GLU A 1 133 ? 1.179   20.318  24.078  1.00 30.32  ? 465 GLU A N   1 
ATOM   1053 C CA  . GLU A 1 133 ? 0.520   21.537  24.525  1.00 35.02  ? 465 GLU A CA  1 
ATOM   1054 C C   . GLU A 1 133 ? 0.112   21.386  25.983  1.00 37.46  ? 465 GLU A C   1 
ATOM   1055 O O   . GLU A 1 133 ? -0.378  20.330  26.394  1.00 37.12  ? 465 GLU A O   1 
ATOM   1056 C CB  . GLU A 1 133 ? -0.707  21.861  23.669  1.00 33.93  ? 465 GLU A CB  1 
ATOM   1057 C CG  . GLU A 1 133 ? -1.350  23.198  24.002  1.00 41.71  ? 465 GLU A CG  1 
ATOM   1058 C CD  . GLU A 1 133 ? -2.603  23.458  23.193  1.00 41.59  ? 465 GLU A CD  1 
ATOM   1059 O OE1 . GLU A 1 133 ? -2.964  22.595  22.365  1.00 39.39  ? 465 GLU A OE1 1 
ATOM   1060 O OE2 . GLU A 1 133 ? -3.229  24.521  23.387  1.00 47.23  ? 465 GLU A OE2 1 
ATOM   1061 N N   . ARG A 1 134 ? 0.329   22.439  26.764  1.00 37.07  ? 466 ARG A N   1 
ATOM   1062 C CA  . ARG A 1 134 ? 0.007   22.449  28.184  1.00 33.38  ? 466 ARG A CA  1 
ATOM   1063 C C   . ARG A 1 134 ? -1.110  23.451  28.433  1.00 38.17  ? 466 ARG A C   1 
ATOM   1064 O O   . ARG A 1 134 ? -0.986  24.627  28.077  1.00 44.11  ? 466 ARG A O   1 
ATOM   1065 C CB  . ARG A 1 134 ? 1.239   22.804  29.020  1.00 42.21  ? 466 ARG A CB  1 
ATOM   1066 C CG  . ARG A 1 134 ? 1.048   22.696  30.529  1.00 36.43  ? 466 ARG A CG  1 
ATOM   1067 C CD  . ARG A 1 134 ? 2.212   23.329  31.299  1.00 44.13  ? 466 ARG A CD  1 
ATOM   1068 N NE  . ARG A 1 134 ? 3.456   22.569  31.204  1.00 50.05  ? 466 ARG A NE  1 
ATOM   1069 C CZ  . ARG A 1 134 ? 4.424   22.810  30.327  1.00 61.78  ? 466 ARG A CZ  1 
ATOM   1070 N NH1 . ARG A 1 134 ? 4.315   23.768  29.422  1.00 56.28  ? 466 ARG A NH1 1 
ATOM   1071 N NH2 . ARG A 1 134 ? 5.529   22.070  30.358  1.00 54.67  ? 466 ARG A NH2 1 
ATOM   1072 N N   . ASP A 1 135 ? -2.194  22.984  29.048  1.00 41.93  ? 467 ASP A N   1 
ATOM   1073 C CA  . ASP A 1 135 ? -3.355  23.815  29.348  1.00 39.28  ? 467 ASP A CA  1 
ATOM   1074 C C   . ASP A 1 135 ? -3.536  23.850  30.861  1.00 42.47  ? 467 ASP A C   1 
ATOM   1075 O O   . ASP A 1 135 ? -3.946  22.852  31.464  1.00 57.07  ? 467 ASP A O   1 
ATOM   1076 C CB  . ASP A 1 135 ? -4.602  23.269  28.653  1.00 42.43  ? 467 ASP A CB  1 
ATOM   1077 C CG  . ASP A 1 135 ? -5.766  24.240  28.687  1.00 47.32  ? 467 ASP A CG  1 
ATOM   1078 O OD1 . ASP A 1 135 ? -5.755  25.163  29.528  1.00 50.46  ? 467 ASP A OD1 1 
ATOM   1079 O OD2 . ASP A 1 135 ? -6.699  24.077  27.873  1.00 38.01  ? 467 ASP A OD2 1 
ATOM   1080 N N   . ILE A 1 136 ? -3.240  24.993  31.473  1.00 34.92  ? 468 ILE A N   1 
ATOM   1081 C CA  . ILE A 1 136 ? -3.343  25.146  32.918  1.00 46.15  ? 468 ILE A CA  1 
ATOM   1082 C C   . ILE A 1 136 ? -4.529  26.031  33.300  1.00 48.32  ? 468 ILE A C   1 
ATOM   1083 O O   . ILE A 1 136 ? -4.592  26.537  34.421  1.00 45.63  ? 468 ILE A O   1 
ATOM   1084 C CB  . ILE A 1 136 ? -2.033  25.680  33.522  1.00 40.81  ? 468 ILE A CB  1 
ATOM   1085 C CG1 . ILE A 1 136 ? -1.750  27.098  33.026  1.00 35.65  ? 468 ILE A CG1 1 
ATOM   1086 C CG2 . ILE A 1 136 ? -0.875  24.753  33.186  1.00 38.52  ? 468 ILE A CG2 1 
ATOM   1087 C CD1 . ILE A 1 136 ? -0.562  27.741  33.696  1.00 38.27  ? 468 ILE A CD1 1 
ATOM   1088 N N   . SER A 1 137 ? -5.473  26.217  32.382  1.00 44.92  ? 469 SER A N   1 
ATOM   1089 C CA  . SER A 1 137 ? -6.638  27.044  32.658  1.00 37.68  ? 469 SER A CA  1 
ATOM   1090 C C   . SER A 1 137 ? -7.528  26.405  33.716  1.00 44.16  ? 469 SER A C   1 
ATOM   1091 O O   . SER A 1 137 ? -7.761  25.193  33.710  1.00 44.86  ? 469 SER A O   1 
ATOM   1092 C CB  . SER A 1 137 ? -7.444  27.269  31.383  1.00 33.16  ? 469 SER A CB  1 
ATOM   1093 O OG  . SER A 1 137 ? -8.646  27.958  31.673  1.00 45.90  ? 469 SER A OG  1 
ATOM   1094 N N   . THR A 1 138 ? -8.032  27.236  34.625  1.00 38.51  ? 470 THR A N   1 
ATOM   1095 C CA  . THR A 1 138 ? -8.988  26.797  35.633  1.00 42.95  ? 470 THR A CA  1 
ATOM   1096 C C   . THR A 1 138 ? -10.334 27.491  35.474  1.00 37.24  ? 470 THR A C   1 
ATOM   1097 O O   . THR A 1 138 ? -11.124 27.536  36.423  1.00 42.71  ? 470 THR A O   1 
ATOM   1098 C CB  . THR A 1 138 ? -8.431  27.029  37.037  1.00 45.36  ? 470 THR A CB  1 
ATOM   1099 O OG1 . THR A 1 138 ? -7.693  28.258  37.059  1.00 43.98  ? 470 THR A OG1 1 
ATOM   1100 C CG2 . THR A 1 138 ? -7.519  25.881  37.435  1.00 38.83  ? 470 THR A CG2 1 
ATOM   1101 N N   . GLU A 1 139 ? -10.606 28.043  34.297  1.00 36.86  ? 471 GLU A N   1 
ATOM   1102 C CA  . GLU A 1 139 ? -11.866 28.733  34.073  1.00 40.79  ? 471 GLU A CA  1 
ATOM   1103 C C   . GLU A 1 139 ? -13.021 27.740  34.081  1.00 46.13  ? 471 GLU A C   1 
ATOM   1104 O O   . GLU A 1 139 ? -12.892 26.607  33.605  1.00 44.73  ? 471 GLU A O   1 
ATOM   1105 C CB  . GLU A 1 139 ? -11.817 29.500  32.752  1.00 42.90  ? 471 GLU A CB  1 
ATOM   1106 C CG  . GLU A 1 139 ? -13.070 30.291  32.428  1.00 68.83  ? 471 GLU A CG  1 
ATOM   1107 C CD  . GLU A 1 139 ? -12.846 31.307  31.326  1.00 74.92  ? 471 GLU A CD  1 
ATOM   1108 O OE1 . GLU A 1 139 ? -13.152 32.498  31.538  1.00 76.97  ? 471 GLU A OE1 1 
ATOM   1109 O OE2 . GLU A 1 139 ? -12.358 30.911  30.246  1.00 76.73  ? 471 GLU A OE2 1 
ATOM   1110 N N   . ILE A 1 140 ? -14.151 28.172  34.647  1.00 46.35  ? 472 ILE A N   1 
ATOM   1111 C CA  . ILE A 1 140 ? -15.321 27.310  34.751  1.00 34.30  ? 472 ILE A CA  1 
ATOM   1112 C C   . ILE A 1 140 ? -15.783 26.915  33.359  1.00 34.33  ? 472 ILE A C   1 
ATOM   1113 O O   . ILE A 1 140 ? -15.947 27.762  32.471  1.00 45.77  ? 472 ILE A O   1 
ATOM   1114 C CB  . ILE A 1 140 ? -16.435 28.020  35.536  1.00 43.41  ? 472 ILE A CB  1 
ATOM   1115 C CG1 . ILE A 1 140 ? -15.995 28.283  36.977  1.00 46.37  ? 472 ILE A CG1 1 
ATOM   1116 C CG2 . ILE A 1 140 ? -17.708 27.198  35.524  1.00 43.76  ? 472 ILE A CG2 1 
ATOM   1117 C CD1 . ILE A 1 140 ? -15.651 27.028  37.748  1.00 44.05  ? 472 ILE A CD1 1 
ATOM   1118 N N   . TYR A 1 141 ? -15.993 25.618  33.161  1.00 39.08  ? 473 TYR A N   1 
ATOM   1119 C CA  . TYR A 1 141 ? -16.360 25.084  31.858  1.00 31.71  ? 473 TYR A CA  1 
ATOM   1120 C C   . TYR A 1 141 ? -17.844 25.321  31.605  1.00 35.23  ? 473 TYR A C   1 
ATOM   1121 O O   . TYR A 1 141 ? -18.693 24.829  32.356  1.00 42.41  ? 473 TYR A O   1 
ATOM   1122 C CB  . TYR A 1 141 ? -16.024 23.598  31.804  1.00 34.34  ? 473 TYR A CB  1 
ATOM   1123 C CG  . TYR A 1 141 ? -16.252 22.953  30.463  1.00 38.58  ? 473 TYR A CG  1 
ATOM   1124 C CD1 . TYR A 1 141 ? -15.283 23.010  29.476  1.00 30.58  ? 473 TYR A CD1 1 
ATOM   1125 C CD2 . TYR A 1 141 ? -17.431 22.272  30.189  1.00 36.39  ? 473 TYR A CD2 1 
ATOM   1126 C CE1 . TYR A 1 141 ? -15.479 22.416  28.250  1.00 36.48  ? 473 TYR A CE1 1 
ATOM   1127 C CE2 . TYR A 1 141 ? -17.638 21.675  28.966  1.00 35.65  ? 473 TYR A CE2 1 
ATOM   1128 C CZ  . TYR A 1 141 ? -16.657 21.750  27.998  1.00 41.52  ? 473 TYR A CZ  1 
ATOM   1129 O OH  . TYR A 1 141 ? -16.849 21.157  26.771  1.00 44.49  ? 473 TYR A OH  1 
ATOM   1130 N N   . GLN A 1 142 ? -18.159 26.059  30.541  1.00 36.78  ? 474 GLN A N   1 
ATOM   1131 C CA  . GLN A 1 142 ? -19.538 26.433  30.227  1.00 44.83  ? 474 GLN A CA  1 
ATOM   1132 C C   . GLN A 1 142 ? -20.168 25.345  29.364  1.00 42.19  ? 474 GLN A C   1 
ATOM   1133 O O   . GLN A 1 142 ? -19.916 25.268  28.159  1.00 41.54  ? 474 GLN A O   1 
ATOM   1134 C CB  . GLN A 1 142 ? -19.575 27.787  29.529  1.00 43.03  ? 474 GLN A CB  1 
ATOM   1135 C CG  . GLN A 1 142 ? -20.962 28.247  29.137  1.00 40.74  ? 474 GLN A CG  1 
ATOM   1136 C CD  . GLN A 1 142 ? -20.953 29.617  28.493  1.00 50.88  ? 474 GLN A CD  1 
ATOM   1137 O OE1 . GLN A 1 142 ? -20.024 30.400  28.688  1.00 51.66  ? 474 GLN A OE1 1 
ATOM   1138 N NE2 . GLN A 1 142 ? -21.988 29.913  27.715  1.00 48.15  ? 474 GLN A NE2 1 
ATOM   1139 N N   . ALA A 1 143 ? -21.007 24.509  29.977  1.00 32.73  ? 475 ALA A N   1 
ATOM   1140 C CA  . ALA A 1 143 ? -21.661 23.420  29.263  1.00 37.18  ? 475 ALA A CA  1 
ATOM   1141 C C   . ALA A 1 143 ? -22.990 23.821  28.638  1.00 43.16  ? 475 ALA A C   1 
ATOM   1142 O O   . ALA A 1 143 ? -23.607 23.000  27.950  1.00 38.48  ? 475 ALA A O   1 
ATOM   1143 C CB  . ALA A 1 143 ? -21.886 22.228  30.199  1.00 36.60  ? 475 ALA A CB  1 
ATOM   1144 N N   . GLY A 1 144 ? -23.451 25.044  28.867  1.00 45.79  ? 476 GLY A N   1 
ATOM   1145 C CA  . GLY A 1 144 ? -24.688 25.496  28.268  1.00 41.41  ? 476 GLY A CA  1 
ATOM   1146 C C   . GLY A 1 144 ? -24.495 26.808  27.543  1.00 46.00  ? 476 GLY A C   1 
ATOM   1147 O O   . GLY A 1 144 ? -23.360 27.226  27.297  1.00 48.34  ? 476 GLY A O   1 
ATOM   1148 N N   . SER A 1 145 ? -25.594 27.468  27.192  1.00 41.63  ? 477 SER A N   1 
ATOM   1149 C CA  . SER A 1 145 ? -25.507 28.765  26.540  1.00 49.08  ? 477 SER A CA  1 
ATOM   1150 C C   . SER A 1 145 ? -25.413 29.916  27.534  1.00 53.55  ? 477 SER A C   1 
ATOM   1151 O O   . SER A 1 145 ? -24.854 30.967  27.200  1.00 47.31  ? 477 SER A O   1 
ATOM   1152 C CB  . SER A 1 145 ? -26.714 28.972  25.625  1.00 44.97  ? 477 SER A CB  1 
ATOM   1153 O OG  . SER A 1 145 ? -27.914 28.924  26.375  1.00 69.81  ? 477 SER A OG  1 
ATOM   1154 N N   . THR A 1 146 ? -25.942 29.743  28.739  1.00 46.78  ? 478 THR A N   1 
ATOM   1155 C CA  . THR A 1 146 ? -25.885 30.804  29.740  1.00 51.31  ? 478 THR A CA  1 
ATOM   1156 C C   . THR A 1 146 ? -24.464 30.945  30.277  1.00 51.78  ? 478 THR A C   1 
ATOM   1157 O O   . THR A 1 146 ? -23.828 29.936  30.603  1.00 63.68  ? 478 THR A O   1 
ATOM   1158 C CB  . THR A 1 146 ? -26.847 30.505  30.887  1.00 51.06  ? 478 THR A CB  1 
ATOM   1159 O OG1 . THR A 1 146 ? -26.353 29.395  31.645  1.00 62.08  ? 478 THR A OG1 1 
ATOM   1160 C CG2 . THR A 1 146 ? -28.227 30.162  30.345  1.00 47.18  ? 478 THR A CG2 1 
ATOM   1161 N N   . PRO A 1 147 ? -23.933 32.164  30.383  1.00 58.14  ? 479 PRO A N   1 
ATOM   1162 C CA  . PRO A 1 147 ? -22.574 32.333  30.914  1.00 53.89  ? 479 PRO A CA  1 
ATOM   1163 C C   . PRO A 1 147 ? -22.482 31.901  32.371  1.00 51.63  ? 479 PRO A C   1 
ATOM   1164 O O   . PRO A 1 147 ? -23.459 31.946  33.121  1.00 50.23  ? 479 PRO A O   1 
ATOM   1165 C CB  . PRO A 1 147 ? -22.315 33.836  30.759  1.00 47.50  ? 479 PRO A CB  1 
ATOM   1166 C CG  . PRO A 1 147 ? -23.279 34.285  29.704  1.00 47.45  ? 479 PRO A CG  1 
ATOM   1167 C CD  . PRO A 1 147 ? -24.498 33.434  29.900  1.00 51.80  ? 479 PRO A CD  1 
ATOM   1168 N N   . CYS A 1 148 ? -21.282 31.471  32.764  1.00 55.25  ? 480 CYS A N   1 
ATOM   1169 C CA  . CYS A 1 148 ? -21.064 30.926  34.099  1.00 55.90  ? 480 CYS A CA  1 
ATOM   1170 C C   . CYS A 1 148 ? -20.607 31.965  35.112  1.00 56.15  ? 480 CYS A C   1 
ATOM   1171 O O   . CYS A 1 148 ? -20.876 31.805  36.309  1.00 52.61  ? 480 CYS A O   1 
ATOM   1172 C CB  . CYS A 1 148 ? -20.039 29.789  34.045  1.00 51.50  ? 480 CYS A CB  1 
ATOM   1173 S SG  . CYS A 1 148 ? -20.639 28.302  33.212  1.00 91.29  ? 480 CYS A SG  1 
ATOM   1174 N N   . ASN A 1 149 ? -19.916 33.016  34.667  1.00 67.40  ? 481 ASN A N   1 
ATOM   1175 C CA  . ASN A 1 149 ? -19.396 34.060  35.557  1.00 66.82  ? 481 ASN A CA  1 
ATOM   1176 C C   . ASN A 1 149 ? -18.496 33.483  36.643  1.00 57.79  ? 481 ASN A C   1 
ATOM   1177 O O   . ASN A 1 149 ? -18.461 33.985  37.769  1.00 55.13  ? 481 ASN A O   1 
ATOM   1178 C CB  . ASN A 1 149 ? -20.530 34.880  36.177  1.00 61.94  ? 481 ASN A CB  1 
ATOM   1179 C CG  . ASN A 1 149 ? -21.256 35.720  35.155  1.00 71.67  ? 481 ASN A CG  1 
ATOM   1180 O OD1 . ASN A 1 149 ? -20.632 36.385  34.327  1.00 60.70  ? 481 ASN A OD1 1 
ATOM   1181 N ND2 . ASN A 1 149 ? -22.583 35.686  35.196  1.00 67.82  ? 481 ASN A ND2 1 
ATOM   1182 N N   . GLY A 1 150 ? -17.768 32.423  36.306  1.00 65.49  ? 482 GLY A N   1 
ATOM   1183 C CA  . GLY A 1 150 ? -16.769 31.875  37.204  1.00 59.55  ? 482 GLY A CA  1 
ATOM   1184 C C   . GLY A 1 150 ? -17.308 31.300  38.492  1.00 64.29  ? 482 GLY A C   1 
ATOM   1185 O O   . GLY A 1 150 ? -16.625 31.358  39.519  1.00 62.41  ? 482 GLY A O   1 
ATOM   1186 N N   . VAL A 1 151 ? -18.517 30.740  38.470  1.00 67.72  ? 483 VAL A N   1 
ATOM   1187 C CA  . VAL A 1 151 ? -19.085 30.040  39.618  1.00 69.41  ? 483 VAL A CA  1 
ATOM   1188 C C   . VAL A 1 151 ? -19.632 28.701  39.142  1.00 60.80  ? 483 VAL A C   1 
ATOM   1189 O O   . VAL A 1 151 ? -20.249 28.617  38.075  1.00 64.11  ? 483 VAL A O   1 
ATOM   1190 C CB  . VAL A 1 151 ? -20.184 30.864  40.335  1.00 62.40  ? 483 VAL A CB  1 
ATOM   1191 C CG1 . VAL A 1 151 ? -19.762 32.310  40.489  1.00 57.42  ? 483 VAL A CG1 1 
ATOM   1192 C CG2 . VAL A 1 151 ? -21.508 30.781  39.600  1.00 52.15  ? 483 VAL A CG2 1 
ATOM   1193 N N   . GLU A 1 152 ? -19.368 27.649  39.913  1.00 49.61  ? 484 GLU A N   1 
ATOM   1194 C CA  . GLU A 1 152 ? -19.877 26.330  39.577  1.00 47.59  ? 484 GLU A CA  1 
ATOM   1195 C C   . GLU A 1 152 ? -21.390 26.283  39.756  1.00 54.96  ? 484 GLU A C   1 
ATOM   1196 O O   . GLU A 1 152 ? -21.963 26.971  40.606  1.00 54.61  ? 484 GLU A O   1 
ATOM   1197 C CB  . GLU A 1 152 ? -19.209 25.255  40.440  1.00 48.68  ? 484 GLU A CB  1 
ATOM   1198 C CG  . GLU A 1 152 ? -17.731 25.023  40.139  1.00 65.79  ? 484 GLU A CG  1 
ATOM   1199 C CD  . GLU A 1 152 ? -17.085 24.043  41.106  1.00 76.88  ? 484 GLU A CD  1 
ATOM   1200 O OE1 . GLU A 1 152 ? -17.826 23.358  41.840  1.00 73.42  ? 484 GLU A OE1 1 
ATOM   1201 O OE2 . GLU A 1 152 ? -15.837 23.960  41.138  1.00 62.42  ? 484 GLU A OE2 1 
ATOM   1202 N N   . GLY A 1 153 ? -22.040 25.466  38.934  1.00 42.30  ? 485 GLY A N   1 
ATOM   1203 C CA  . GLY A 1 153 ? -23.486 25.362  38.989  1.00 42.42  ? 485 GLY A CA  1 
ATOM   1204 C C   . GLY A 1 153 ? -24.005 24.510  37.850  1.00 46.89  ? 485 GLY A C   1 
ATOM   1205 O O   . GLY A 1 153 ? -23.289 23.662  37.314  1.00 59.35  ? 485 GLY A O   1 
ATOM   1206 N N   . PHE A 1 154 ? -25.265 24.745  37.498  1.00 43.01  ? 486 PHE A N   1 
ATOM   1207 C CA  . PHE A 1 154 ? -25.880 24.017  36.397  1.00 40.37  ? 486 PHE A CA  1 
ATOM   1208 C C   . PHE A 1 154 ? -25.197 24.394  35.087  1.00 43.65  ? 486 PHE A C   1 
ATOM   1209 O O   . PHE A 1 154 ? -25.043 25.579  34.777  1.00 51.03  ? 486 PHE A O   1 
ATOM   1210 C CB  . PHE A 1 154 ? -27.375 24.322  36.342  1.00 39.91  ? 486 PHE A CB  1 
ATOM   1211 C CG  . PHE A 1 154 ? -28.130 23.484  35.356  1.00 51.37  ? 486 PHE A CG  1 
ATOM   1212 C CD1 . PHE A 1 154 ? -28.365 22.141  35.606  1.00 59.55  ? 486 PHE A CD1 1 
ATOM   1213 C CD2 . PHE A 1 154 ? -28.614 24.037  34.182  1.00 53.86  ? 486 PHE A CD2 1 
ATOM   1214 C CE1 . PHE A 1 154 ? -29.061 21.366  34.699  1.00 54.41  ? 486 PHE A CE1 1 
ATOM   1215 C CE2 . PHE A 1 154 ? -29.311 23.267  33.273  1.00 52.77  ? 486 PHE A CE2 1 
ATOM   1216 C CZ  . PHE A 1 154 ? -29.534 21.931  33.533  1.00 61.50  ? 486 PHE A CZ  1 
ATOM   1217 N N   . ASN A 1 155 ? -24.772 23.381  34.328  1.00 48.21  ? 487 ASN A N   1 
ATOM   1218 C CA  . ASN A 1 155 ? -24.046 23.574  33.069  1.00 42.07  ? 487 ASN A CA  1 
ATOM   1219 C C   . ASN A 1 155 ? -22.773 24.399  33.258  1.00 40.92  ? 487 ASN A C   1 
ATOM   1220 O O   . ASN A 1 155 ? -22.310 25.064  32.328  1.00 43.60  ? 487 ASN A O   1 
ATOM   1221 C CB  . ASN A 1 155 ? -24.941 24.210  31.999  1.00 36.87  ? 487 ASN A CB  1 
ATOM   1222 C CG  . ASN A 1 155 ? -26.034 23.274  31.528  1.00 37.43  ? 487 ASN A CG  1 
ATOM   1223 O OD1 . ASN A 1 155 ? -25.919 22.056  31.660  1.00 53.37  ? 487 ASN A OD1 1 
ATOM   1224 N ND2 . ASN A 1 155 ? -27.098 23.837  30.970  1.00 36.64  ? 487 ASN A ND2 1 
ATOM   1225 N N   . CYS A 1 156 ? -22.194 24.352  34.461  1.00 45.86  ? 488 CYS A N   1 
ATOM   1226 C CA  . CYS A 1 156 ? -20.977 25.098  34.799  1.00 42.08  ? 488 CYS A CA  1 
ATOM   1227 C C   . CYS A 1 156 ? -20.122 24.218  35.705  1.00 47.26  ? 488 CYS A C   1 
ATOM   1228 O O   . CYS A 1 156 ? -20.340 24.172  36.920  1.00 50.76  ? 488 CYS A O   1 
ATOM   1229 C CB  . CYS A 1 156 ? -21.301 26.421  35.479  1.00 45.98  ? 488 CYS A CB  1 
ATOM   1230 S SG  . CYS A 1 156 ? -22.127 27.604  34.419  1.00 47.49  ? 488 CYS A SG  1 
ATOM   1231 N N   . TYR A 1 157 ? -19.137 23.550  35.119  1.00 42.15  ? 489 TYR A N   1 
ATOM   1232 C CA  . TYR A 1 157 ? -18.331 22.569  35.823  1.00 43.18  ? 489 TYR A CA  1 
ATOM   1233 C C   . TYR A 1 157 ? -16.904 23.073  35.989  1.00 41.91  ? 489 TYR A C   1 
ATOM   1234 O O   . TYR A 1 157 ? -16.400 23.840  35.164  1.00 41.98  ? 489 TYR A O   1 
ATOM   1235 C CB  . TYR A 1 157 ? -18.319 21.238  35.066  1.00 41.85  ? 489 TYR A CB  1 
ATOM   1236 C CG  . TYR A 1 157 ? -19.681 20.764  34.603  1.00 37.43  ? 489 TYR A CG  1 
ATOM   1237 C CD1 . TYR A 1 157 ? -20.787 20.827  35.441  1.00 38.00  ? 489 TYR A CD1 1 
ATOM   1238 C CD2 . TYR A 1 157 ? -19.857 20.253  33.324  1.00 38.50  ? 489 TYR A CD2 1 
ATOM   1239 C CE1 . TYR A 1 157 ? -22.028 20.391  35.019  1.00 43.29  ? 489 TYR A CE1 1 
ATOM   1240 C CE2 . TYR A 1 157 ? -21.093 19.816  32.893  1.00 41.80  ? 489 TYR A CE2 1 
ATOM   1241 C CZ  . TYR A 1 157 ? -22.175 19.887  33.745  1.00 50.60  ? 489 TYR A CZ  1 
ATOM   1242 O OH  . TYR A 1 157 ? -23.411 19.454  33.328  1.00 59.32  ? 489 TYR A OH  1 
ATOM   1243 N N   . PHE A 1 158 ? -16.258 22.643  37.065  1.00 40.08  ? 490 PHE A N   1 
ATOM   1244 C CA  . PHE A 1 158 ? -14.828 22.879  37.201  1.00 41.13  ? 490 PHE A CA  1 
ATOM   1245 C C   . PHE A 1 158 ? -14.088 21.966  36.229  1.00 42.54  ? 490 PHE A C   1 
ATOM   1246 O O   . PHE A 1 158 ? -14.326 20.752  36.224  1.00 36.94  ? 490 PHE A O   1 
ATOM   1247 C CB  . PHE A 1 158 ? -14.366 22.620  38.635  1.00 44.29  ? 490 PHE A CB  1 
ATOM   1248 C CG  . PHE A 1 158 ? -13.036 23.246  38.972  1.00 64.07  ? 490 PHE A CG  1 
ATOM   1249 C CD1 . PHE A 1 158 ? -11.848 22.684  38.525  1.00 55.68  ? 490 PHE A CD1 1 
ATOM   1250 C CD2 . PHE A 1 158 ? -12.973 24.388  39.754  1.00 67.58  ? 490 PHE A CD2 1 
ATOM   1251 C CE1 . PHE A 1 158 ? -10.627 23.259  38.840  1.00 41.20  ? 490 PHE A CE1 1 
ATOM   1252 C CE2 . PHE A 1 158 ? -11.753 24.965  40.075  1.00 51.14  ? 490 PHE A CE2 1 
ATOM   1253 C CZ  . PHE A 1 158 ? -10.581 24.399  39.617  1.00 37.02  ? 490 PHE A CZ  1 
ATOM   1254 N N   . PRO A 1 159 ? -13.203 22.504  35.385  1.00 43.46  ? 491 PRO A N   1 
ATOM   1255 C CA  . PRO A 1 159 ? -12.562 21.665  34.358  1.00 37.45  ? 491 PRO A CA  1 
ATOM   1256 C C   . PRO A 1 159 ? -11.675 20.569  34.920  1.00 46.94  ? 491 PRO A C   1 
ATOM   1257 O O   . PRO A 1 159 ? -11.426 19.577  34.221  1.00 43.21  ? 491 PRO A O   1 
ATOM   1258 C CB  . PRO A 1 159 ? -11.748 22.676  33.541  1.00 36.14  ? 491 PRO A CB  1 
ATOM   1259 C CG  . PRO A 1 159 ? -11.482 23.793  34.493  1.00 39.19  ? 491 PRO A CG  1 
ATOM   1260 C CD  . PRO A 1 159 ? -12.711 23.892  35.352  1.00 41.62  ? 491 PRO A CD  1 
ATOM   1261 N N   . LEU A 1 160 ? -11.199 20.706  36.151  1.00 46.87  ? 492 LEU A N   1 
ATOM   1262 C CA  . LEU A 1 160 ? -10.239 19.779  36.727  1.00 36.75  ? 492 LEU A CA  1 
ATOM   1263 C C   . LEU A 1 160 ? -10.921 18.824  37.699  1.00 38.42  ? 492 LEU A C   1 
ATOM   1264 O O   . LEU A 1 160 ? -11.879 19.183  38.386  1.00 39.96  ? 492 LEU A O   1 
ATOM   1265 C CB  . LEU A 1 160 ? -9.119  20.536  37.441  1.00 29.06  ? 492 LEU A CB  1 
ATOM   1266 C CG  . LEU A 1 160 ? -7.894  20.946  36.620  1.00 35.43  ? 492 LEU A CG  1 
ATOM   1267 C CD1 . LEU A 1 160 ? -8.266  21.498  35.252  1.00 34.54  ? 492 LEU A CD1 1 
ATOM   1268 C CD2 . LEU A 1 160 ? -7.095  21.972  37.394  1.00 38.53  ? 492 LEU A CD2 1 
ATOM   1269 N N   . GLN A 1 161 ? -10.411 17.597  37.744  1.00 44.19  ? 493 GLN A N   1 
ATOM   1270 C CA  . GLN A 1 161 ? -10.899 16.560  38.638  1.00 36.57  ? 493 GLN A CA  1 
ATOM   1271 C C   . GLN A 1 161 ? -9.717  16.000  39.420  1.00 55.17  ? 493 GLN A C   1 
ATOM   1272 O O   . GLN A 1 161 ? -8.565  16.089  38.985  1.00 42.53  ? 493 GLN A O   1 
ATOM   1273 C CB  . GLN A 1 161 ? -11.613 15.442  37.859  1.00 45.10  ? 493 GLN A CB  1 
ATOM   1274 C CG  . GLN A 1 161 ? -12.467 14.502  38.702  1.00 48.89  ? 493 GLN A CG  1 
ATOM   1275 C CD  . GLN A 1 161 ? -13.853 15.054  38.975  1.00 64.50  ? 493 GLN A CD  1 
ATOM   1276 O OE1 . GLN A 1 161 ? -14.126 16.231  38.735  1.00 54.25  ? 493 GLN A OE1 1 
ATOM   1277 N NE2 . GLN A 1 161 ? -14.740 14.200  39.474  1.00 68.59  ? 493 GLN A NE2 1 
ATOM   1278 N N   . SER A 1 162 ? -10.009 15.431  40.588  1.00 59.42  ? 494 SER A N   1 
ATOM   1279 C CA  . SER A 1 162 ? -8.987  14.888  41.472  1.00 46.79  ? 494 SER A CA  1 
ATOM   1280 C C   . SER A 1 162 ? -8.891  13.376  41.316  1.00 37.47  ? 494 SER A C   1 
ATOM   1281 O O   . SER A 1 162 ? -9.908  12.682  41.239  1.00 40.67  ? 494 SER A O   1 
ATOM   1282 C CB  . SER A 1 162 ? -9.283  15.238  42.931  1.00 58.52  ? 494 SER A CB  1 
ATOM   1283 O OG  . SER A 1 162 ? -8.286  14.705  43.782  1.00 57.75  ? 494 SER A OG  1 
ATOM   1284 N N   . TYR A 1 163 ? -7.656  12.870  41.274  1.00 33.97  ? 495 TYR A N   1 
ATOM   1285 C CA  . TYR A 1 163 ? -7.448  11.435  41.108  1.00 40.06  ? 495 TYR A CA  1 
ATOM   1286 C C   . TYR A 1 163 ? -7.839  10.669  42.366  1.00 47.35  ? 495 TYR A C   1 
ATOM   1287 O O   . TYR A 1 163 ? -8.515  9.636   42.290  1.00 66.75  ? 495 TYR A O   1 
ATOM   1288 C CB  . TYR A 1 163 ? -5.992  11.157  40.738  1.00 36.75  ? 495 TYR A CB  1 
ATOM   1289 C CG  . TYR A 1 163 ? -5.730  11.107  39.250  1.00 38.94  ? 495 TYR A CG  1 
ATOM   1290 C CD1 . TYR A 1 163 ? -6.533  10.349  38.407  1.00 36.58  ? 495 TYR A CD1 1 
ATOM   1291 C CD2 . TYR A 1 163 ? -4.678  11.818  38.688  1.00 40.03  ? 495 TYR A CD2 1 
ATOM   1292 C CE1 . TYR A 1 163 ? -6.292  10.299  37.047  1.00 37.09  ? 495 TYR A CE1 1 
ATOM   1293 C CE2 . TYR A 1 163 ? -4.431  11.774  37.332  1.00 40.98  ? 495 TYR A CE2 1 
ATOM   1294 C CZ  . TYR A 1 163 ? -5.240  11.014  36.516  1.00 35.39  ? 495 TYR A CZ  1 
ATOM   1295 O OH  . TYR A 1 163 ? -4.995  10.971  35.165  1.00 41.78  ? 495 TYR A OH  1 
ATOM   1296 N N   . GLY A 1 164 ? -7.420  11.155  43.532  1.00 53.49  ? 496 GLY A N   1 
ATOM   1297 C CA  . GLY A 1 164 ? -7.708  10.482  44.784  1.00 54.72  ? 496 GLY A CA  1 
ATOM   1298 C C   . GLY A 1 164 ? -7.078  9.108   44.917  1.00 66.84  ? 496 GLY A C   1 
ATOM   1299 O O   . GLY A 1 164 ? -7.772  8.139   45.241  1.00 82.04  ? 496 GLY A O   1 
ATOM   1300 N N   . PHE A 1 165 ? -5.773  9.004   44.660  1.00 63.96  ? 497 PHE A N   1 
ATOM   1301 C CA  . PHE A 1 165 ? -5.085  7.720   44.763  1.00 60.06  ? 497 PHE A CA  1 
ATOM   1302 C C   . PHE A 1 165 ? -5.115  7.200   46.194  1.00 72.49  ? 497 PHE A C   1 
ATOM   1303 O O   . PHE A 1 165 ? -4.807  7.931   47.139  1.00 86.14  ? 497 PHE A O   1 
ATOM   1304 C CB  . PHE A 1 165 ? -3.635  7.851   44.296  1.00 54.02  ? 497 PHE A CB  1 
ATOM   1305 C CG  . PHE A 1 165 ? -3.491  8.295   42.872  1.00 47.59  ? 497 PHE A CG  1 
ATOM   1306 C CD1 . PHE A 1 165 ? -3.954  7.504   41.836  1.00 43.82  ? 497 PHE A CD1 1 
ATOM   1307 C CD2 . PHE A 1 165 ? -2.878  9.498   42.568  1.00 47.00  ? 497 PHE A CD2 1 
ATOM   1308 C CE1 . PHE A 1 165 ? -3.821  7.906   40.526  1.00 43.73  ? 497 PHE A CE1 1 
ATOM   1309 C CE2 . PHE A 1 165 ? -2.738  9.907   41.257  1.00 37.40  ? 497 PHE A CE2 1 
ATOM   1310 C CZ  . PHE A 1 165 ? -3.208  9.109   40.235  1.00 44.85  ? 497 PHE A CZ  1 
ATOM   1311 N N   . GLN A 1 166 ? -5.464  5.926   46.350  1.00 67.39  ? 498 GLN A N   1 
ATOM   1312 C CA  . GLN A 1 166 ? -5.465  5.266   47.645  1.00 62.27  ? 498 GLN A CA  1 
ATOM   1313 C C   . GLN A 1 166 ? -4.686  3.963   47.558  1.00 71.05  ? 498 GLN A C   1 
ATOM   1314 O O   . GLN A 1 166 ? -4.652  3.324   46.501  1.00 79.37  ? 498 GLN A O   1 
ATOM   1315 C CB  . GLN A 1 166 ? -6.893  4.976   48.129  1.00 74.53  ? 498 GLN A CB  1 
ATOM   1316 C CG  . GLN A 1 166 ? -7.683  6.213   48.504  1.00 77.02  ? 498 GLN A CG  1 
ATOM   1317 C CD  . GLN A 1 166 ? -9.047  5.882   49.072  1.00 95.63  ? 498 GLN A CD  1 
ATOM   1318 O OE1 . GLN A 1 166 ? -9.440  6.406   50.114  1.00 112.50 ? 498 GLN A OE1 1 
ATOM   1319 N NE2 . GLN A 1 166 ? -9.780  5.012   48.386  1.00 81.19  ? 498 GLN A NE2 1 
ATOM   1320 N N   . PRO A 1 167 ? -4.041  3.552   48.653  1.00 65.42  ? 499 PRO A N   1 
ATOM   1321 C CA  . PRO A 1 167 ? -3.255  2.307   48.611  1.00 59.90  ? 499 PRO A CA  1 
ATOM   1322 C C   . PRO A 1 167 ? -4.084  1.062   48.348  1.00 71.27  ? 499 PRO A C   1 
ATOM   1323 O O   . PRO A 1 167 ? -3.571  0.102   47.759  1.00 66.87  ? 499 PRO A O   1 
ATOM   1324 C CB  . PRO A 1 167 ? -2.595  2.265   49.996  1.00 58.21  ? 499 PRO A CB  1 
ATOM   1325 C CG  . PRO A 1 167 ? -3.465  3.116   50.859  1.00 68.32  ? 499 PRO A CG  1 
ATOM   1326 C CD  . PRO A 1 167 ? -3.963  4.211   49.967  1.00 62.67  ? 499 PRO A CD  1 
ATOM   1327 N N   . THR A 1 168 ? -5.351  1.045   48.761  1.00 76.70  ? 500 THR A N   1 
ATOM   1328 C CA  . THR A 1 168 ? -6.181  -0.150  48.664  1.00 91.41  ? 500 THR A CA  1 
ATOM   1329 C C   . THR A 1 168 ? -6.774  -0.364  47.277  1.00 86.87  ? 500 THR A C   1 
ATOM   1330 O O   . THR A 1 168 ? -7.419  -1.395  47.051  1.00 82.02  ? 500 THR A O   1 
ATOM   1331 C CB  . THR A 1 168 ? -7.312  -0.090  49.696  1.00 99.00  ? 500 THR A CB  1 
ATOM   1332 O OG1 . THR A 1 168 ? -8.114  1.076   49.460  1.00 94.50  ? 500 THR A OG1 1 
ATOM   1333 C CG2 . THR A 1 168 ? -6.744  -0.033  51.108  1.00 82.83  ? 500 THR A CG2 1 
ATOM   1334 N N   . ASN A 1 169 ? -6.577  0.570   46.351  1.00 88.76  ? 501 ASN A N   1 
ATOM   1335 C CA  . ASN A 1 169 ? -7.180  0.458   45.033  1.00 90.59  ? 501 ASN A CA  1 
ATOM   1336 C C   . ASN A 1 169 ? -6.453  -0.585  44.186  1.00 77.13  ? 501 ASN A C   1 
ATOM   1337 O O   . ASN A 1 169 ? -5.333  -1.007  44.488  1.00 72.55  ? 501 ASN A O   1 
ATOM   1338 C CB  . ASN A 1 169 ? -7.167  1.811   44.318  1.00 76.57  ? 501 ASN A CB  1 
ATOM   1339 C CG  . ASN A 1 169 ? -7.889  2.897   45.097  1.00 80.26  ? 501 ASN A CG  1 
ATOM   1340 O OD1 . ASN A 1 169 ? -7.448  4.046   45.128  1.00 71.74  ? 501 ASN A OD1 1 
ATOM   1341 N ND2 . ASN A 1 169 ? -9.003  2.541   45.726  1.00 80.73  ? 501 ASN A ND2 1 
ATOM   1342 N N   . GLY A 1 170 ? -7.112  -0.995  43.105  1.00 70.29  ? 502 GLY A N   1 
ATOM   1343 C CA  . GLY A 1 170 ? -6.522  -1.943  42.183  1.00 63.05  ? 502 GLY A CA  1 
ATOM   1344 C C   . GLY A 1 170 ? -5.390  -1.332  41.383  1.00 48.00  ? 502 GLY A C   1 
ATOM   1345 O O   . GLY A 1 170 ? -5.223  -0.115  41.306  1.00 62.16  ? 502 GLY A O   1 
ATOM   1346 N N   . VAL A 1 171 ? -4.615  -2.213  40.747  1.00 48.01  ? 503 VAL A N   1 
ATOM   1347 C CA  . VAL A 1 171 ? -3.358  -1.803  40.125  1.00 45.11  ? 503 VAL A CA  1 
ATOM   1348 C C   . VAL A 1 171 ? -3.594  -0.717  39.084  1.00 50.29  ? 503 VAL A C   1 
ATOM   1349 O O   . VAL A 1 171 ? -2.805  0.227   38.962  1.00 58.30  ? 503 VAL A O   1 
ATOM   1350 C CB  . VAL A 1 171 ? -2.645  -3.023  39.515  1.00 54.62  ? 503 VAL A CB  1 
ATOM   1351 C CG1 . VAL A 1 171 ? -1.163  -2.730  39.324  1.00 43.33  ? 503 VAL A CG1 1 
ATOM   1352 C CG2 . VAL A 1 171 ? -2.860  -4.255  40.386  1.00 59.44  ? 503 VAL A CG2 1 
ATOM   1353 N N   . GLY A 1 172 ? -4.677  -0.834  38.312  1.00 46.64  ? 504 GLY A N   1 
ATOM   1354 C CA  . GLY A 1 172 ? -4.989  0.196   37.336  1.00 50.02  ? 504 GLY A CA  1 
ATOM   1355 C C   . GLY A 1 172 ? -5.295  1.538   37.969  1.00 50.28  ? 504 GLY A C   1 
ATOM   1356 O O   . GLY A 1 172 ? -4.986  2.587   37.398  1.00 56.88  ? 504 GLY A O   1 
ATOM   1357 N N   . TYR A 1 173 ? -5.908  1.526   39.151  1.00 47.48  ? 505 TYR A N   1 
ATOM   1358 C CA  . TYR A 1 173 ? -6.268  2.757   39.841  1.00 48.02  ? 505 TYR A CA  1 
ATOM   1359 C C   . TYR A 1 173 ? -5.076  3.418   40.522  1.00 47.16  ? 505 TYR A C   1 
ATOM   1360 O O   . TYR A 1 173 ? -5.157  4.599   40.875  1.00 48.68  ? 505 TYR A O   1 
ATOM   1361 C CB  . TYR A 1 173 ? -7.351  2.476   40.888  1.00 51.56  ? 505 TYR A CB  1 
ATOM   1362 C CG  . TYR A 1 173 ? -8.692  1.998   40.354  1.00 57.91  ? 505 TYR A CG  1 
ATOM   1363 C CD1 . TYR A 1 173 ? -8.778  0.959   39.434  1.00 58.78  ? 505 TYR A CD1 1 
ATOM   1364 C CD2 . TYR A 1 173 ? -9.878  2.563   40.808  1.00 69.47  ? 505 TYR A CD2 1 
ATOM   1365 C CE1 . TYR A 1 173 ? -9.997  0.519   38.957  1.00 69.20  ? 505 TYR A CE1 1 
ATOM   1366 C CE2 . TYR A 1 173 ? -11.106 2.126   40.339  1.00 71.62  ? 505 TYR A CE2 1 
ATOM   1367 C CZ  . TYR A 1 173 ? -11.157 1.103   39.414  1.00 74.96  ? 505 TYR A CZ  1 
ATOM   1368 O OH  . TYR A 1 173 ? -12.367 0.656   38.940  1.00 72.59  ? 505 TYR A OH  1 
ATOM   1369 N N   . GLN A 1 174 ? -3.982  2.686   40.719  1.00 42.81  ? 506 GLN A N   1 
ATOM   1370 C CA  . GLN A 1 174 ? -2.863  3.202   41.489  1.00 47.78  ? 506 GLN A CA  1 
ATOM   1371 C C   . GLN A 1 174 ? -2.073  4.228   40.677  1.00 49.91  ? 506 GLN A C   1 
ATOM   1372 O O   . GLN A 1 174 ? -2.041  4.165   39.444  1.00 50.62  ? 506 GLN A O   1 
ATOM   1373 C CB  . GLN A 1 174 ? -1.953  2.058   41.923  1.00 46.26  ? 506 GLN A CB  1 
ATOM   1374 C CG  . GLN A 1 174 ? -2.703  0.955   42.648  1.00 60.02  ? 506 GLN A CG  1 
ATOM   1375 C CD  . GLN A 1 174 ? -1.794  0.040   43.433  1.00 65.81  ? 506 GLN A CD  1 
ATOM   1376 O OE1 . GLN A 1 174 ? -0.863  -0.552  42.886  1.00 59.11  ? 506 GLN A OE1 1 
ATOM   1377 N NE2 . GLN A 1 174 ? -2.057  -0.079  44.730  1.00 61.97  ? 506 GLN A NE2 1 
ATOM   1378 N N   . PRO A 1 175 ? -1.436  5.191   41.343  1.00 47.50  ? 507 PRO A N   1 
ATOM   1379 C CA  . PRO A 1 175 ? -0.681  6.211   40.610  1.00 48.23  ? 507 PRO A CA  1 
ATOM   1380 C C   . PRO A 1 175 ? 0.538   5.623   39.917  1.00 45.70  ? 507 PRO A C   1 
ATOM   1381 O O   . PRO A 1 175 ? 1.153   4.666   40.391  1.00 51.01  ? 507 PRO A O   1 
ATOM   1382 C CB  . PRO A 1 175 ? -0.273  7.204   41.703  1.00 44.07  ? 507 PRO A CB  1 
ATOM   1383 C CG  . PRO A 1 175 ? -0.248  6.390   42.949  1.00 48.56  ? 507 PRO A CG  1 
ATOM   1384 C CD  . PRO A 1 175 ? -1.361  5.392   42.801  1.00 43.33  ? 507 PRO A CD  1 
ATOM   1385 N N   . TYR A 1 176 ? 0.887   6.218   38.779  1.00 40.74  ? 508 TYR A N   1 
ATOM   1386 C CA  . TYR A 1 176 ? 2.070   5.822   38.024  1.00 32.84  ? 508 TYR A CA  1 
ATOM   1387 C C   . TYR A 1 176 ? 2.822   7.073   37.602  1.00 35.59  ? 508 TYR A C   1 
ATOM   1388 O O   . TYR A 1 176 ? 2.276   7.910   36.877  1.00 37.76  ? 508 TYR A O   1 
ATOM   1389 C CB  . TYR A 1 176 ? 1.694   4.984   36.799  1.00 36.02  ? 508 TYR A CB  1 
ATOM   1390 C CG  . TYR A 1 176 ? 1.562   3.503   37.074  1.00 35.68  ? 508 TYR A CG  1 
ATOM   1391 C CD1 . TYR A 1 176 ? 0.452   2.994   37.733  1.00 41.30  ? 508 TYR A CD1 1 
ATOM   1392 C CD2 . TYR A 1 176 ? 2.545   2.612   36.663  1.00 44.67  ? 508 TYR A CD2 1 
ATOM   1393 C CE1 . TYR A 1 176 ? 0.328   1.638   37.983  1.00 52.85  ? 508 TYR A CE1 1 
ATOM   1394 C CE2 . TYR A 1 176 ? 2.430   1.256   36.907  1.00 44.28  ? 508 TYR A CE2 1 
ATOM   1395 C CZ  . TYR A 1 176 ? 1.321   0.774   37.567  1.00 50.65  ? 508 TYR A CZ  1 
ATOM   1396 O OH  . TYR A 1 176 ? 1.206   -0.575  37.811  1.00 53.77  ? 508 TYR A OH  1 
ATOM   1397 N N   . ARG A 1 177 ? 4.065   7.206   38.054  1.00 34.18  ? 509 ARG A N   1 
ATOM   1398 C CA  . ARG A 1 177 ? 4.902   8.301   37.587  1.00 36.32  ? 509 ARG A CA  1 
ATOM   1399 C C   . ARG A 1 177 ? 5.366   8.007   36.169  1.00 33.92  ? 509 ARG A C   1 
ATOM   1400 O O   . ARG A 1 177 ? 5.864   6.915   35.883  1.00 37.10  ? 509 ARG A O   1 
ATOM   1401 C CB  . ARG A 1 177 ? 6.097   8.500   38.518  1.00 37.36  ? 509 ARG A CB  1 
ATOM   1402 C CG  . ARG A 1 177 ? 5.762   9.258   39.789  1.00 39.26  ? 509 ARG A CG  1 
ATOM   1403 C CD  . ARG A 1 177 ? 6.775   9.002   40.888  1.00 52.78  ? 509 ARG A CD  1 
ATOM   1404 N NE  . ARG A 1 177 ? 6.388   9.667   42.128  1.00 56.59  ? 509 ARG A NE  1 
ATOM   1405 C CZ  . ARG A 1 177 ? 7.166   10.497  42.810  1.00 52.36  ? 509 ARG A CZ  1 
ATOM   1406 N NH1 . ARG A 1 177 ? 8.412   10.739  42.439  1.00 52.25  ? 509 ARG A NH1 1 
ATOM   1407 N NH2 . ARG A 1 177 ? 6.683   11.091  43.897  1.00 53.68  ? 509 ARG A NH2 1 
ATOM   1408 N N   . VAL A 1 178 ? 5.183   8.976   35.275  1.00 39.67  ? 510 VAL A N   1 
ATOM   1409 C CA  . VAL A 1 178 ? 5.502   8.819   33.861  1.00 42.67  ? 510 VAL A CA  1 
ATOM   1410 C C   . VAL A 1 178 ? 6.512   9.887   33.468  1.00 34.59  ? 510 VAL A C   1 
ATOM   1411 O O   . VAL A 1 178 ? 6.312   11.075  33.753  1.00 32.40  ? 510 VAL A O   1 
ATOM   1412 C CB  . VAL A 1 178 ? 4.242   8.903   32.980  1.00 30.59  ? 510 VAL A CB  1 
ATOM   1413 C CG1 . VAL A 1 178 ? 4.614   8.844   31.506  1.00 24.01  ? 510 VAL A CG1 1 
ATOM   1414 C CG2 . VAL A 1 178 ? 3.280   7.782   33.328  1.00 26.39  ? 510 VAL A CG2 1 
ATOM   1415 N N   . VAL A 1 179 ? 7.598   9.462   32.828  1.00 30.70  ? 511 VAL A N   1 
ATOM   1416 C CA  . VAL A 1 179 ? 8.600   10.361  32.269  1.00 40.45  ? 511 VAL A CA  1 
ATOM   1417 C C   . VAL A 1 179 ? 8.688   10.081  30.775  1.00 45.82  ? 511 VAL A C   1 
ATOM   1418 O O   . VAL A 1 179 ? 8.929   8.937   30.367  1.00 42.66  ? 511 VAL A O   1 
ATOM   1419 C CB  . VAL A 1 179 ? 9.972   10.191  32.941  1.00 45.00  ? 511 VAL A CB  1 
ATOM   1420 C CG1 . VAL A 1 179 ? 10.975  11.164  32.342  1.00 38.89  ? 511 VAL A CG1 1 
ATOM   1421 C CG2 . VAL A 1 179 ? 9.858   10.397  34.444  1.00 45.00  ? 511 VAL A CG2 1 
ATOM   1422 N N   . VAL A 1 180 ? 8.496   11.118  29.964  1.00 43.50  ? 512 VAL A N   1 
ATOM   1423 C CA  . VAL A 1 180 ? 8.499   10.996  28.510  1.00 37.36  ? 512 VAL A CA  1 
ATOM   1424 C C   . VAL A 1 180 ? 9.741   11.694  27.979  1.00 43.89  ? 512 VAL A C   1 
ATOM   1425 O O   . VAL A 1 180 ? 9.915   12.904  28.170  1.00 42.99  ? 512 VAL A O   1 
ATOM   1426 C CB  . VAL A 1 180 ? 7.228   11.589  27.884  1.00 31.89  ? 512 VAL A CB  1 
ATOM   1427 C CG1 . VAL A 1 180 ? 7.272   11.437  26.375  1.00 28.02  ? 512 VAL A CG1 1 
ATOM   1428 C CG2 . VAL A 1 180 ? 5.994   10.916  28.456  1.00 32.69  ? 512 VAL A CG2 1 
ATOM   1429 N N   . LEU A 1 181 ? 10.594  10.934  27.301  1.00 44.24  ? 513 LEU A N   1 
ATOM   1430 C CA  . LEU A 1 181 ? 11.851  11.442  26.768  1.00 44.45  ? 513 LEU A CA  1 
ATOM   1431 C C   . LEU A 1 181 ? 11.655  11.803  25.303  1.00 44.03  ? 513 LEU A C   1 
ATOM   1432 O O   . LEU A 1 181 ? 11.289  10.947  24.490  1.00 43.35  ? 513 LEU A O   1 
ATOM   1433 C CB  . LEU A 1 181 ? 12.967  10.409  26.928  1.00 44.37  ? 513 LEU A CB  1 
ATOM   1434 C CG  . LEU A 1 181 ? 13.884  10.496  28.154  1.00 43.17  ? 513 LEU A CG  1 
ATOM   1435 C CD1 . LEU A 1 181 ? 13.122  10.860  29.418  1.00 41.61  ? 513 LEU A CD1 1 
ATOM   1436 C CD2 . LEU A 1 181 ? 14.613  9.178   28.347  1.00 40.35  ? 513 LEU A CD2 1 
ATOM   1437 N N   . SER A 1 182 ? 11.888  13.066  24.974  1.00 53.01  ? 514 SER A N   1 
ATOM   1438 C CA  . SER A 1 182 ? 11.758  13.565  23.614  1.00 50.95  ? 514 SER A CA  1 
ATOM   1439 C C   . SER A 1 182 ? 13.133  13.988  23.120  1.00 51.63  ? 514 SER A C   1 
ATOM   1440 O O   . SER A 1 182 ? 13.830  14.754  23.793  1.00 51.65  ? 514 SER A O   1 
ATOM   1441 C CB  . SER A 1 182 ? 10.773  14.735  23.555  1.00 44.31  ? 514 SER A CB  1 
ATOM   1442 O OG  . SER A 1 182 ? 10.662  15.246  22.240  1.00 52.75  ? 514 SER A OG  1 
ATOM   1443 N N   . PHE A 1 183 ? 13.524  13.477  21.959  1.00 56.55  ? 515 PHE A N   1 
ATOM   1444 C CA  . PHE A 1 183 ? 14.829  13.755  21.379  1.00 59.01  ? 515 PHE A CA  1 
ATOM   1445 C C   . PHE A 1 183 ? 14.659  14.672  20.178  1.00 80.04  ? 515 PHE A C   1 
ATOM   1446 O O   . PHE A 1 183 ? 13.833  14.405  19.299  1.00 84.63  ? 515 PHE A O   1 
ATOM   1447 C CB  . PHE A 1 183 ? 15.536  12.461  20.975  1.00 49.68  ? 515 PHE A CB  1 
ATOM   1448 C CG  . PHE A 1 183 ? 15.796  11.536  22.128  1.00 58.62  ? 515 PHE A CG  1 
ATOM   1449 C CD1 . PHE A 1 183 ? 16.938  11.675  22.900  1.00 54.68  ? 515 PHE A CD1 1 
ATOM   1450 C CD2 . PHE A 1 183 ? 14.893  10.537  22.451  1.00 58.37  ? 515 PHE A CD2 1 
ATOM   1451 C CE1 . PHE A 1 183 ? 17.178  10.831  23.967  1.00 56.04  ? 515 PHE A CE1 1 
ATOM   1452 C CE2 . PHE A 1 183 ? 15.127  9.688   23.518  1.00 50.64  ? 515 PHE A CE2 1 
ATOM   1453 C CZ  . PHE A 1 183 ? 16.271  9.836   24.276  1.00 50.53  ? 515 PHE A CZ  1 
ATOM   1454 N N   . GLU A 1 184 ? 15.432  15.753  20.155  1.00 85.00  ? 516 GLU A N   1 
ATOM   1455 C CA  . GLU A 1 184 ? 15.369  16.753  19.100  1.00 88.27  ? 516 GLU A CA  1 
ATOM   1456 C C   . GLU A 1 184 ? 16.722  16.825  18.407  1.00 91.12  ? 516 GLU A C   1 
ATOM   1457 O O   . GLU A 1 184 ? 17.753  16.999  19.065  1.00 85.90  ? 516 GLU A O   1 
ATOM   1458 C CB  . GLU A 1 184 ? 14.981  18.120  19.672  1.00 77.16  ? 516 GLU A CB  1 
ATOM   1459 C CG  . GLU A 1 184 ? 14.434  19.096  18.648  1.00 91.54  ? 516 GLU A CG  1 
ATOM   1460 C CD  . GLU A 1 184 ? 14.198  20.477  19.231  1.00 103.77 ? 516 GLU A CD  1 
ATOM   1461 O OE1 . GLU A 1 184 ? 14.516  20.685  20.422  1.00 87.62  ? 516 GLU A OE1 1 
ATOM   1462 O OE2 . GLU A 1 184 ? 13.696  21.354  18.497  1.00 102.75 ? 516 GLU A OE2 1 
ATOM   1463 N N   . LEU A 1 185 ? 16.717  16.694  17.084  1.00 95.03  ? 517 LEU A N   1 
ATOM   1464 C CA  . LEU A 1 185 ? 17.951  16.740  16.308  1.00 90.37  ? 517 LEU A CA  1 
ATOM   1465 C C   . LEU A 1 185 ? 17.793  17.693  15.127  1.00 77.43  ? 517 LEU A C   1 
ATOM   1466 O O   . LEU A 1 185 ? 18.680  18.497  14.844  1.00 72.76  ? 517 LEU A O   1 
ATOM   1467 C CB  . LEU A 1 185 ? 18.335  15.335  15.825  1.00 87.06  ? 517 LEU A CB  1 
ATOM   1468 C CG  . LEU A 1 185 ? 19.764  15.083  15.325  1.00 77.28  ? 517 LEU A CG  1 
ATOM   1469 C CD1 . LEU A 1 185 ? 20.148  13.624  15.536  1.00 65.99  ? 517 LEU A CD1 1 
ATOM   1470 C CD2 . LEU A 1 185 ? 19.932  15.464  13.858  1.00 57.71  ? 517 LEU A CD2 1 
ATOM   1471 N N   . ALA A 1 188 ? 22.070  22.053  13.030  1.00 79.87  ? 520 ALA A N   1 
ATOM   1472 C CA  . ALA A 1 188 ? 22.210  22.771  14.293  1.00 91.36  ? 520 ALA A CA  1 
ATOM   1473 C C   . ALA A 1 188 ? 23.271  22.120  15.186  1.00 97.26  ? 520 ALA A C   1 
ATOM   1474 O O   . ALA A 1 188 ? 23.463  20.904  15.132  1.00 80.69  ? 520 ALA A O   1 
ATOM   1475 C CB  . ALA A 1 188 ? 20.871  22.836  15.010  1.00 86.41  ? 520 ALA A CB  1 
ATOM   1476 N N   . PRO A 1 189 ? 23.966  22.926  15.993  1.00 108.93 ? 521 PRO A N   1 
ATOM   1477 C CA  . PRO A 1 189 ? 24.994  22.369  16.885  1.00 103.00 ? 521 PRO A CA  1 
ATOM   1478 C C   . PRO A 1 189 ? 24.405  21.374  17.877  1.00 95.29  ? 521 PRO A C   1 
ATOM   1479 O O   . PRO A 1 189 ? 23.299  21.558  18.389  1.00 100.59 ? 521 PRO A O   1 
ATOM   1480 C CB  . PRO A 1 189 ? 25.553  23.607  17.599  1.00 88.59  ? 521 PRO A CB  1 
ATOM   1481 C CG  . PRO A 1 189 ? 25.239  24.748  16.688  1.00 74.79  ? 521 PRO A CG  1 
ATOM   1482 C CD  . PRO A 1 189 ? 23.926  24.399  16.048  1.00 90.82  ? 521 PRO A CD  1 
ATOM   1483 N N   . ALA A 1 190 ? 25.168  20.318  18.160  1.00 80.92  ? 522 ALA A N   1 
ATOM   1484 C CA  . ALA A 1 190 ? 24.741  19.251  19.060  1.00 81.05  ? 522 ALA A CA  1 
ATOM   1485 C C   . ALA A 1 190 ? 25.310  19.515  20.451  1.00 84.51  ? 522 ALA A C   1 
ATOM   1486 O O   . ALA A 1 190 ? 26.524  19.423  20.659  1.00 97.96  ? 522 ALA A O   1 
ATOM   1487 C CB  . ALA A 1 190 ? 25.188  17.887  18.538  1.00 82.43  ? 522 ALA A CB  1 
ATOM   1488 N N   . THR A 1 191 ? 24.433  19.831  21.404  1.00 86.98  ? 523 THR A N   1 
ATOM   1489 C CA  . THR A 1 191 ? 24.862  20.147  22.761  1.00 87.56  ? 523 THR A CA  1 
ATOM   1490 C C   . THR A 1 191 ? 24.755  18.975  23.727  1.00 85.28  ? 523 THR A C   1 
ATOM   1491 O O   . THR A 1 191 ? 25.381  19.016  24.792  1.00 81.16  ? 523 THR A O   1 
ATOM   1492 C CB  . THR A 1 191 ? 24.050  21.322  23.319  1.00 83.42  ? 523 THR A CB  1 
ATOM   1493 O OG1 . THR A 1 191 ? 22.653  21.004  23.278  1.00 87.34  ? 523 THR A OG1 1 
ATOM   1494 C CG2 . THR A 1 191 ? 24.307  22.579  22.502  1.00 87.37  ? 523 THR A CG2 1 
ATOM   1495 N N   . VAL A 1 192 ? 23.982  17.945  23.394  1.00 85.32  ? 524 VAL A N   1 
ATOM   1496 C CA  . VAL A 1 192 ? 23.791  16.784  24.258  1.00 82.32  ? 524 VAL A CA  1 
ATOM   1497 C C   . VAL A 1 192 ? 24.315  15.556  23.531  1.00 82.09  ? 524 VAL A C   1 
ATOM   1498 O O   . VAL A 1 192 ? 23.870  15.251  22.417  1.00 84.89  ? 524 VAL A O   1 
ATOM   1499 C CB  . VAL A 1 192 ? 22.318  16.594  24.649  1.00 77.58  ? 524 VAL A CB  1 
ATOM   1500 C CG1 . VAL A 1 192 ? 22.162  15.376  25.552  1.00 65.26  ? 524 VAL A CG1 1 
ATOM   1501 C CG2 . VAL A 1 192 ? 21.789  17.840  25.329  1.00 77.36  ? 524 VAL A CG2 1 
ATOM   1502 N N   . CYS A 1 193 ? 25.250  14.853  24.163  1.00 76.22  ? 525 CYS A N   1 
ATOM   1503 C CA  . CYS A 1 193 ? 25.821  13.630  23.622  1.00 80.17  ? 525 CYS A CA  1 
ATOM   1504 C C   . CYS A 1 193 ? 25.998  12.628  24.753  1.00 79.43  ? 525 CYS A C   1 
ATOM   1505 O O   . CYS A 1 193 ? 26.066  12.995  25.928  1.00 72.69  ? 525 CYS A O   1 
ATOM   1506 C CB  . CYS A 1 193 ? 27.176  13.876  22.941  1.00 83.01  ? 525 CYS A CB  1 
ATOM   1507 S SG  . CYS A 1 193 ? 27.185  15.011  21.528  1.00 122.40 ? 525 CYS A SG  1 
ATOM   1508 N N   . GLY A 1 194 ? 26.073  11.350  24.385  1.00 85.28  ? 526 GLY A N   1 
ATOM   1509 C CA  . GLY A 1 194 ? 26.388  10.316  25.340  1.00 74.65  ? 526 GLY A CA  1 
ATOM   1510 C C   . GLY A 1 194 ? 27.877  10.216  25.590  1.00 79.23  ? 526 GLY A C   1 
ATOM   1511 O O   . GLY A 1 194 ? 28.693  10.957  25.025  1.00 81.75  ? 526 GLY A O   1 
ATOM   1512 N N   . PRO A 1 195 ? 28.253  9.286   26.469  1.00 80.83  ? 527 PRO A N   1 
ATOM   1513 C CA  . PRO A 1 195 ? 29.680  9.047   26.719  1.00 78.36  ? 527 PRO A CA  1 
ATOM   1514 C C   . PRO A 1 195 ? 30.384  8.576   25.454  1.00 90.23  ? 527 PRO A C   1 
ATOM   1515 O O   . PRO A 1 195 ? 29.788  7.917   24.601  1.00 97.94  ? 527 PRO A O   1 
ATOM   1516 C CB  . PRO A 1 195 ? 29.676  7.960   27.801  1.00 59.77  ? 527 PRO A CB  1 
ATOM   1517 C CG  . PRO A 1 195 ? 28.322  8.063   28.441  1.00 56.10  ? 527 PRO A CG  1 
ATOM   1518 C CD  . PRO A 1 195 ? 27.393  8.467   27.339  1.00 76.02  ? 527 PRO A CD  1 
ATOM   1519 N N   . LYS A 1 196 ? 31.665  8.932   25.345  1.00 80.73  ? 528 LYS A N   1 
ATOM   1520 C CA  . LYS A 1 196 ? 32.500  8.670   24.161  1.00 84.54  ? 528 LYS A CA  1 
ATOM   1521 C C   . LYS A 1 196 ? 31.760  8.886   22.837  1.00 84.67  ? 528 LYS A C   1 
ATOM   1522 O O   . LYS A 1 196 ? 31.214  9.961   22.582  1.00 69.89  ? 528 LYS A O   1 
ATOM   1523 C CB  . LYS A 1 196 ? 33.088  7.245   24.211  1.00 94.75  ? 528 LYS A CB  1 
ATOM   1524 C CG  . LYS A 1 196 ? 32.108  6.084   24.001  1.00 90.98  ? 528 LYS A CG  1 
ATOM   1525 C CD  . LYS A 1 196 ? 32.073  5.607   22.551  1.00 111.74 ? 528 LYS A CD  1 
ATOM   1526 C CE  . LYS A 1 196 ? 31.029  4.515   22.347  1.00 104.23 ? 528 LYS A CE  1 
ATOM   1527 N NZ  . LYS A 1 196 ? 30.975  4.051   20.931  1.00 95.38  ? 528 LYS A NZ  1 
ATOM   1528 N N   . GLN B 2 1   ? -34.320 23.630  32.658  1.00 79.75  ? 1   GLN F N   1 
ATOM   1529 C CA  . GLN B 2 1   ? -34.960 22.416  32.164  1.00 66.71  ? 1   GLN F CA  1 
ATOM   1530 C C   . GLN B 2 1   ? -34.092 21.731  31.112  1.00 63.80  ? 1   GLN F C   1 
ATOM   1531 O O   . GLN B 2 1   ? -33.397 22.386  30.337  1.00 72.74  ? 1   GLN F O   1 
ATOM   1532 C CB  . GLN B 2 1   ? -36.345 22.730  31.585  1.00 48.36  ? 1   GLN F CB  1 
ATOM   1533 C CG  . GLN B 2 1   ? -36.336 23.447  30.234  1.00 77.83  ? 1   GLN F CG  1 
ATOM   1534 C CD  . GLN B 2 1   ? -35.840 24.882  30.318  1.00 104.64 ? 1   GLN F CD  1 
ATOM   1535 O OE1 . GLN B 2 1   ? -35.706 25.444  31.406  1.00 109.32 ? 1   GLN F OE1 1 
ATOM   1536 N NE2 . GLN B 2 1   ? -35.565 25.480  29.164  1.00 97.07  ? 1   GLN F NE2 1 
ATOM   1537 N N   . VAL B 2 2   ? -34.130 20.402  31.099  1.00 50.57  ? 2   VAL F N   1 
ATOM   1538 C CA  . VAL B 2 2   ? -33.386 19.594  30.142  1.00 42.28  ? 2   VAL F CA  1 
ATOM   1539 C C   . VAL B 2 2   ? -34.363 18.632  29.487  1.00 48.72  ? 2   VAL F C   1 
ATOM   1540 O O   . VAL B 2 2   ? -35.187 18.016  30.172  1.00 54.49  ? 2   VAL F O   1 
ATOM   1541 C CB  . VAL B 2 2   ? -32.230 18.824  30.809  1.00 43.24  ? 2   VAL F CB  1 
ATOM   1542 C CG1 . VAL B 2 2   ? -31.496 17.963  29.788  1.00 34.97  ? 2   VAL F CG1 1 
ATOM   1543 C CG2 . VAL B 2 2   ? -31.273 19.786  31.484  1.00 51.59  ? 2   VAL F CG2 1 
ATOM   1544 N N   . GLN B 2 3   ? -34.284 18.516  28.165  1.00 46.15  ? 3   GLN F N   1 
ATOM   1545 C CA  . GLN B 2 3   ? -35.132 17.606  27.412  1.00 37.50  ? 3   GLN F CA  1 
ATOM   1546 C C   . GLN B 2 3   ? -34.265 16.712  26.540  1.00 40.24  ? 3   GLN F C   1 
ATOM   1547 O O   . GLN B 2 3   ? -33.270 17.164  25.967  1.00 38.42  ? 3   GLN F O   1 
ATOM   1548 C CB  . GLN B 2 3   ? -36.141 18.374  26.553  1.00 37.04  ? 3   GLN F CB  1 
ATOM   1549 C CG  . GLN B 2 3   ? -37.043 19.286  27.362  1.00 41.58  ? 3   GLN F CG  1 
ATOM   1550 C CD  . GLN B 2 3   ? -38.265 19.728  26.591  1.00 42.67  ? 3   GLN F CD  1 
ATOM   1551 O OE1 . GLN B 2 3   ? -38.805 18.976  25.780  1.00 49.81  ? 3   GLN F OE1 1 
ATOM   1552 N NE2 . GLN B 2 3   ? -38.710 20.954  26.838  1.00 42.24  ? 3   GLN F NE2 1 
ATOM   1553 N N   . LEU B 2 4   ? -34.638 15.436  26.460  1.00 33.43  ? 4   LEU F N   1 
ATOM   1554 C CA  . LEU B 2 4   ? -33.976 14.479  25.576  1.00 28.45  ? 4   LEU F CA  1 
ATOM   1555 C C   . LEU B 2 4   ? -35.057 13.624  24.932  1.00 35.72  ? 4   LEU F C   1 
ATOM   1556 O O   . LEU B 2 4   ? -35.656 12.775  25.597  1.00 42.56  ? 4   LEU F O   1 
ATOM   1557 C CB  . LEU B 2 4   ? -32.973 13.611  26.336  1.00 32.13  ? 4   LEU F CB  1 
ATOM   1558 C CG  . LEU B 2 4   ? -31.676 14.275  26.809  1.00 34.29  ? 4   LEU F CG  1 
ATOM   1559 C CD1 . LEU B 2 4   ? -30.901 13.359  27.742  1.00 32.96  ? 4   LEU F CD1 1 
ATOM   1560 C CD2 . LEU B 2 4   ? -30.818 14.654  25.619  1.00 34.64  ? 4   LEU F CD2 1 
ATOM   1561 N N   . VAL B 2 5   ? -35.307 13.846  23.646  1.00 31.89  ? 5   VAL F N   1 
ATOM   1562 C CA  . VAL B 2 5   ? -36.349 13.144  22.909  1.00 37.40  ? 5   VAL F CA  1 
ATOM   1563 C C   . VAL B 2 5   ? -35.683 12.287  21.844  1.00 45.94  ? 5   VAL F C   1 
ATOM   1564 O O   . VAL B 2 5   ? -34.790 12.759  21.129  1.00 43.60  ? 5   VAL F O   1 
ATOM   1565 C CB  . VAL B 2 5   ? -37.353 14.128  22.283  1.00 35.18  ? 5   VAL F CB  1 
ATOM   1566 C CG1 . VAL B 2 5   ? -38.570 13.378  21.754  1.00 31.39  ? 5   VAL F CG1 1 
ATOM   1567 C CG2 . VAL B 2 5   ? -37.758 15.177  23.300  1.00 35.84  ? 5   VAL F CG2 1 
ATOM   1568 N N   . GLU B 2 6   ? -36.111 11.033  21.740  1.00 46.95  ? 6   GLU F N   1 
ATOM   1569 C CA  . GLU B 2 6   ? -35.503 10.073  20.834  1.00 48.10  ? 6   GLU F CA  1 
ATOM   1570 C C   . GLU B 2 6   ? -36.420 9.758   19.660  1.00 43.48  ? 6   GLU F C   1 
ATOM   1571 O O   . GLU B 2 6   ? -37.625 10.021  19.690  1.00 51.05  ? 6   GLU F O   1 
ATOM   1572 C CB  . GLU B 2 6   ? -35.144 8.785   21.572  1.00 40.81  ? 6   GLU F CB  1 
ATOM   1573 C CG  . GLU B 2 6   ? -33.827 8.875   22.301  1.00 42.57  ? 6   GLU F CG  1 
ATOM   1574 C CD  . GLU B 2 6   ? -33.880 8.228   23.657  1.00 48.37  ? 6   GLU F CD  1 
ATOM   1575 O OE1 . GLU B 2 6   ? -34.669 8.691   24.506  1.00 52.97  ? 6   GLU F OE1 1 
ATOM   1576 O OE2 . GLU B 2 6   ? -33.140 7.249   23.870  1.00 57.49  ? 6   GLU F OE2 1 
ATOM   1577 N N   . SER B 2 7   ? -35.822 9.185   18.619  1.00 32.53  ? 7   SER F N   1 
ATOM   1578 C CA  . SER B 2 7   ? -36.540 8.852   17.399  1.00 39.74  ? 7   SER F CA  1 
ATOM   1579 C C   . SER B 2 7   ? -35.761 7.782   16.646  1.00 47.44  ? 7   SER F C   1 
ATOM   1580 O O   . SER B 2 7   ? -34.574 7.561   16.898  1.00 48.64  ? 7   SER F O   1 
ATOM   1581 C CB  . SER B 2 7   ? -36.750 10.093  16.524  1.00 37.31  ? 7   SER F CB  1 
ATOM   1582 O OG  . SER B 2 7   ? -37.002 9.735   15.176  1.00 70.02  ? 7   SER F OG  1 
ATOM   1583 N N   . GLY B 2 8   ? -36.448 7.120   15.714  1.00 42.29  ? 8   GLY F N   1 
ATOM   1584 C CA  . GLY B 2 8   ? -35.814 6.188   14.805  1.00 41.47  ? 8   GLY F CA  1 
ATOM   1585 C C   . GLY B 2 8   ? -36.028 4.719   15.106  1.00 43.94  ? 8   GLY F C   1 
ATOM   1586 O O   . GLY B 2 8   ? -35.703 3.881   14.255  1.00 45.33  ? 8   GLY F O   1 
ATOM   1587 N N   . GLY B 2 9   ? -36.554 4.376   16.279  1.00 41.30  ? 9   GLY F N   1 
ATOM   1588 C CA  . GLY B 2 9   ? -36.751 2.977   16.607  1.00 40.70  ? 9   GLY F CA  1 
ATOM   1589 C C   . GLY B 2 9   ? -37.836 2.333   15.764  1.00 41.75  ? 9   GLY F C   1 
ATOM   1590 O O   . GLY B 2 9   ? -38.827 2.959   15.390  1.00 49.19  ? 9   GLY F O   1 
ATOM   1591 N N   . GLY B 2 10  ? -37.641 1.052   15.471  1.00 44.54  ? 10  GLY F N   1 
ATOM   1592 C CA  . GLY B 2 10  ? -38.613 0.308   14.698  1.00 40.68  ? 10  GLY F CA  1 
ATOM   1593 C C   . GLY B 2 10  ? -38.093 -1.077  14.368  1.00 47.97  ? 10  GLY F C   1 
ATOM   1594 O O   . GLY B 2 10  ? -37.084 -1.531  14.913  1.00 54.39  ? 10  GLY F O   1 
ATOM   1595 N N   . LEU B 2 11  ? -38.812 -1.740  13.465  1.00 53.08  ? 11  LEU F N   1 
ATOM   1596 C CA  . LEU B 2 11  ? -38.465 -3.085  13.025  1.00 48.87  ? 11  LEU F CA  1 
ATOM   1597 C C   . LEU B 2 11  ? -37.459 -3.030  11.881  1.00 48.15  ? 11  LEU F C   1 
ATOM   1598 O O   . LEU B 2 11  ? -37.551 -2.174  10.996  1.00 50.91  ? 11  LEU F O   1 
ATOM   1599 C CB  . LEU B 2 11  ? -39.722 -3.844  12.591  1.00 40.24  ? 11  LEU F CB  1 
ATOM   1600 C CG  . LEU B 2 11  ? -39.539 -5.266  12.057  1.00 44.41  ? 11  LEU F CG  1 
ATOM   1601 C CD1 . LEU B 2 11  ? -38.830 -6.140  13.079  1.00 50.28  ? 11  LEU F CD1 1 
ATOM   1602 C CD2 . LEU B 2 11  ? -40.883 -5.868  11.670  1.00 42.08  ? 11  LEU F CD2 1 
ATOM   1603 N N   . ILE B 2 12  ? -36.497 -3.950  11.906  1.00 45.63  ? 12  ILE F N   1 
ATOM   1604 C CA  . ILE B 2 12  ? -35.454 -4.024  10.887  1.00 50.07  ? 12  ILE F CA  1 
ATOM   1605 C C   . ILE B 2 12  ? -34.984 -5.470  10.790  1.00 54.78  ? 12  ILE F C   1 
ATOM   1606 O O   . ILE B 2 12  ? -34.843 -6.160  11.803  1.00 55.53  ? 12  ILE F O   1 
ATOM   1607 C CB  . ILE B 2 12  ? -34.288 -3.058  11.205  1.00 53.09  ? 12  ILE F CB  1 
ATOM   1608 C CG1 . ILE B 2 12  ? -33.127 -3.238  10.222  1.00 55.07  ? 12  ILE F CG1 1 
ATOM   1609 C CG2 . ILE B 2 12  ? -33.807 -3.248  12.632  1.00 55.24  ? 12  ILE F CG2 1 
ATOM   1610 C CD1 . ILE B 2 12  ? -33.464 -2.884  8.792   1.00 55.50  ? 12  ILE F CD1 1 
ATOM   1611 N N   . GLN B 2 13  ? -34.763 -5.933  9.562   1.00 55.70  ? 13  GLN F N   1 
ATOM   1612 C CA  . GLN B 2 13  ? -34.291 -7.291  9.354   1.00 54.10  ? 13  GLN F CA  1 
ATOM   1613 C C   . GLN B 2 13  ? -32.846 -7.430  9.835   1.00 58.03  ? 13  GLN F C   1 
ATOM   1614 O O   . GLN B 2 13  ? -32.098 -6.448  9.866   1.00 57.94  ? 13  GLN F O   1 
ATOM   1615 C CB  . GLN B 2 13  ? -34.380 -7.670  7.879   1.00 57.99  ? 13  GLN F CB  1 
ATOM   1616 C CG  . GLN B 2 13  ? -33.440 -6.871  6.990   1.00 83.57  ? 13  GLN F CG  1 
ATOM   1617 C CD  . GLN B 2 13  ? -33.108 -7.584  5.695   1.00 90.51  ? 13  GLN F CD  1 
ATOM   1618 O OE1 . GLN B 2 13  ? -33.662 -8.642  5.396   1.00 92.59  ? 13  GLN F OE1 1 
ATOM   1619 N NE2 . GLN B 2 13  ? -32.202 -7.003  4.916   1.00 83.54  ? 13  GLN F NE2 1 
ATOM   1620 N N   . PRO B 2 14  ? -32.434 -8.636  10.230  1.00 54.91  ? 14  PRO F N   1 
ATOM   1621 C CA  . PRO B 2 14  ? -31.032 -8.843  10.609  1.00 46.21  ? 14  PRO F CA  1 
ATOM   1622 C C   . PRO B 2 14  ? -30.095 -8.504  9.460   1.00 52.38  ? 14  PRO F C   1 
ATOM   1623 O O   . PRO B 2 14  ? -30.374 -8.796  8.296   1.00 55.30  ? 14  PRO F O   1 
ATOM   1624 C CB  . PRO B 2 14  ? -30.978 -10.332 10.964  1.00 30.76  ? 14  PRO F CB  1 
ATOM   1625 C CG  . PRO B 2 14  ? -32.365 -10.653 11.391  1.00 41.67  ? 14  PRO F CG  1 
ATOM   1626 C CD  . PRO B 2 14  ? -33.257 -9.825  10.507  1.00 55.62  ? 14  PRO F CD  1 
ATOM   1627 N N   . GLY B 2 15  ? -28.973 -7.876  9.803   1.00 58.30  ? 15  GLY F N   1 
ATOM   1628 C CA  . GLY B 2 15  ? -28.049 -7.370  8.814   1.00 46.88  ? 15  GLY F CA  1 
ATOM   1629 C C   . GLY B 2 15  ? -28.409 -6.017  8.242   1.00 57.61  ? 15  GLY F C   1 
ATOM   1630 O O   . GLY B 2 15  ? -27.636 -5.478  7.440   1.00 52.12  ? 15  GLY F O   1 
ATOM   1631 N N   . GLY B 2 16  ? -29.550 -5.446  8.628   1.00 58.61  ? 16  GLY F N   1 
ATOM   1632 C CA  . GLY B 2 16  ? -29.955 -4.145  8.146   1.00 56.92  ? 16  GLY F CA  1 
ATOM   1633 C C   . GLY B 2 16  ? -29.322 -3.009  8.928   1.00 63.34  ? 16  GLY F C   1 
ATOM   1634 O O   . GLY B 2 16  ? -28.574 -3.202  9.887   1.00 65.61  ? 16  GLY F O   1 
ATOM   1635 N N   . SER B 2 17  ? -29.643 -1.790  8.501   1.00 68.09  ? 17  SER F N   1 
ATOM   1636 C CA  . SER B 2 17  ? -29.108 -0.579  9.102   1.00 52.69  ? 17  SER F CA  1 
ATOM   1637 C C   . SER B 2 17  ? -30.238 0.273   9.663   1.00 50.52  ? 17  SER F C   1 
ATOM   1638 O O   . SER B 2 17  ? -31.351 0.291   9.129   1.00 62.35  ? 17  SER F O   1 
ATOM   1639 C CB  . SER B 2 17  ? -28.299 0.238   8.086   1.00 52.72  ? 17  SER F CB  1 
ATOM   1640 O OG  . SER B 2 17  ? -27.180 -0.492  7.616   1.00 65.21  ? 17  SER F OG  1 
ATOM   1641 N N   . LEU B 2 18  ? -29.937 0.980   10.750  1.00 59.05  ? 18  LEU F N   1 
ATOM   1642 C CA  . LEU B 2 18  ? -30.904 1.853   11.400  1.00 54.23  ? 18  LEU F CA  1 
ATOM   1643 C C   . LEU B 2 18  ? -30.156 2.965   12.125  1.00 45.76  ? 18  LEU F C   1 
ATOM   1644 O O   . LEU B 2 18  ? -29.082 2.733   12.686  1.00 53.94  ? 18  LEU F O   1 
ATOM   1645 C CB  . LEU B 2 18  ? -31.785 1.065   12.376  1.00 37.79  ? 18  LEU F CB  1 
ATOM   1646 C CG  . LEU B 2 18  ? -32.940 1.835   13.011  1.00 46.02  ? 18  LEU F CG  1 
ATOM   1647 C CD1 . LEU B 2 18  ? -33.870 2.360   11.930  1.00 57.38  ? 18  LEU F CD1 1 
ATOM   1648 C CD2 . LEU B 2 18  ? -33.690 0.957   14.003  1.00 45.17  ? 18  LEU F CD2 1 
ATOM   1649 N N   . ARG B 2 19  ? -30.724 4.171   12.105  1.00 45.56  ? 19  ARG F N   1 
ATOM   1650 C CA  . ARG B 2 19  ? -30.139 5.333   12.765  1.00 41.75  ? 19  ARG F CA  1 
ATOM   1651 C C   . ARG B 2 19  ? -31.110 5.864   13.808  1.00 42.02  ? 19  ARG F C   1 
ATOM   1652 O O   . ARG B 2 19  ? -32.301 6.031   13.525  1.00 47.69  ? 19  ARG F O   1 
ATOM   1653 C CB  . ARG B 2 19  ? -29.798 6.440   11.763  1.00 40.76  ? 19  ARG F CB  1 
ATOM   1654 C CG  . ARG B 2 19  ? -28.968 7.570   12.357  1.00 36.81  ? 19  ARG F CG  1 
ATOM   1655 C CD  . ARG B 2 19  ? -28.907 8.763   11.426  1.00 32.91  ? 19  ARG F CD  1 
ATOM   1656 N NE  . ARG B 2 19  ? -30.220 9.375   11.277  1.00 54.95  ? 19  ARG F NE  1 
ATOM   1657 C CZ  . ARG B 2 19  ? -30.456 10.500  10.617  1.00 57.23  ? 19  ARG F CZ  1 
ATOM   1658 N NH1 . ARG B 2 19  ? -29.480 11.172  10.027  1.00 46.28  ? 19  ARG F NH1 1 
ATOM   1659 N NH2 . ARG B 2 19  ? -31.701 10.964  10.549  1.00 59.08  ? 19  ARG F NH2 1 
ATOM   1660 N N   . LEU B 2 20  ? -30.598 6.134   15.005  1.00 40.32  ? 20  LEU F N   1 
ATOM   1661 C CA  . LEU B 2 20  ? -31.393 6.655   16.108  1.00 38.47  ? 20  LEU F CA  1 
ATOM   1662 C C   . LEU B 2 20  ? -31.013 8.105   16.363  1.00 42.17  ? 20  LEU F C   1 
ATOM   1663 O O   . LEU B 2 20  ? -29.827 8.429   16.478  1.00 51.15  ? 20  LEU F O   1 
ATOM   1664 C CB  . LEU B 2 20  ? -31.186 5.825   17.375  1.00 36.75  ? 20  LEU F CB  1 
ATOM   1665 C CG  . LEU B 2 20  ? -31.532 4.342   17.264  1.00 37.79  ? 20  LEU F CG  1 
ATOM   1666 C CD1 . LEU B 2 20  ? -31.556 3.703   18.639  1.00 38.52  ? 20  LEU F CD1 1 
ATOM   1667 C CD2 . LEU B 2 20  ? -32.865 4.160   16.559  1.00 43.08  ? 20  LEU F CD2 1 
ATOM   1668 N N   . SER B 2 21  ? -32.018 8.970   16.451  1.00 40.91  ? 21  SER F N   1 
ATOM   1669 C CA  . SER B 2 21  ? -31.819 10.391  16.688  1.00 41.71  ? 21  SER F CA  1 
ATOM   1670 C C   . SER B 2 21  ? -32.214 10.737  18.117  1.00 43.85  ? 21  SER F C   1 
ATOM   1671 O O   . SER B 2 21  ? -33.087 10.097  18.709  1.00 39.16  ? 21  SER F O   1 
ATOM   1672 C CB  . SER B 2 21  ? -32.637 11.237  15.708  1.00 40.23  ? 21  SER F CB  1 
ATOM   1673 O OG  . SER B 2 21  ? -32.278 10.960  14.366  1.00 57.91  ? 21  SER F OG  1 
ATOM   1674 N N   . CYS B 2 22  ? -31.565 11.764  18.665  1.00 43.73  ? 22  CYS F N   1 
ATOM   1675 C CA  . CYS B 2 22  ? -31.846 12.197  20.031  1.00 33.24  ? 22  CYS F CA  1 
ATOM   1676 C C   . CYS B 2 22  ? -31.677 13.713  20.092  1.00 38.51  ? 22  CYS F C   1 
ATOM   1677 O O   . CYS B 2 22  ? -30.556 14.206  20.240  1.00 37.94  ? 22  CYS F O   1 
ATOM   1678 C CB  . CYS B 2 22  ? -30.936 11.493  21.026  1.00 34.90  ? 22  CYS F CB  1 
ATOM   1679 S SG  . CYS B 2 22  ? -31.026 12.161  22.704  1.00 53.49  ? 22  CYS F SG  1 
ATOM   1680 N N   . ALA B 2 23  ? -32.789 14.437  19.976  1.00 42.01  ? 23  ALA F N   1 
ATOM   1681 C CA  . ALA B 2 23  ? -32.763 15.887  20.120  1.00 43.16  ? 23  ALA F CA  1 
ATOM   1682 C C   . ALA B 2 23  ? -32.527 16.276  21.574  1.00 42.37  ? 23  ALA F C   1 
ATOM   1683 O O   . ALA B 2 23  ? -33.107 15.691  22.493  1.00 44.78  ? 23  ALA F O   1 
ATOM   1684 C CB  . ALA B 2 23  ? -34.072 16.497  19.623  1.00 39.53  ? 23  ALA F CB  1 
ATOM   1685 N N   . ALA B 2 24  ? -31.685 17.286  21.779  1.00 39.12  ? 24  ALA F N   1 
ATOM   1686 C CA  . ALA B 2 24  ? -31.279 17.708  23.112  1.00 33.60  ? 24  ALA F CA  1 
ATOM   1687 C C   . ALA B 2 24  ? -31.580 19.184  23.321  1.00 40.79  ? 24  ALA F C   1 
ATOM   1688 O O   . ALA B 2 24  ? -31.365 20.010  22.427  1.00 38.93  ? 24  ALA F O   1 
ATOM   1689 C CB  . ALA B 2 24  ? -29.789 17.450  23.347  1.00 30.65  ? 24  ALA F CB  1 
ATOM   1690 N N   . SER B 2 25  ? -32.071 19.504  24.513  1.00 38.23  ? 25  SER F N   1 
ATOM   1691 C CA  . SER B 2 25  ? -32.371 20.871  24.898  1.00 44.12  ? 25  SER F CA  1 
ATOM   1692 C C   . SER B 2 25  ? -31.929 21.082  26.338  1.00 53.94  ? 25  SER F C   1 
ATOM   1693 O O   . SER B 2 25  ? -31.903 20.143  27.138  1.00 54.27  ? 25  SER F O   1 
ATOM   1694 C CB  . SER B 2 25  ? -33.864 21.177  24.748  1.00 42.83  ? 25  SER F CB  1 
ATOM   1695 O OG  . SER B 2 25  ? -34.155 22.489  25.186  1.00 68.52  ? 25  SER F OG  1 
ATOM   1696 N N   . GLY B 2 26  ? -31.586 22.328  26.664  1.00 46.89  ? 26  GLY F N   1 
ATOM   1697 C CA  . GLY B 2 26  ? -31.151 22.680  27.997  1.00 42.74  ? 26  GLY F CA  1 
ATOM   1698 C C   . GLY B 2 26  ? -29.655 22.655  28.220  1.00 41.64  ? 26  GLY F C   1 
ATOM   1699 O O   . GLY B 2 26  ? -29.199 23.066  29.295  1.00 42.28  ? 26  GLY F O   1 
ATOM   1700 N N   . PHE B 2 27  ? -28.878 22.188  27.249  1.00 46.59  ? 27  PHE F N   1 
ATOM   1701 C CA  . PHE B 2 27  ? -27.427 22.179  27.361  1.00 43.92  ? 27  PHE F CA  1 
ATOM   1702 C C   . PHE B 2 27  ? -26.855 22.149  25.951  1.00 38.61  ? 27  PHE F C   1 
ATOM   1703 O O   . PHE B 2 27  ? -27.572 21.929  24.973  1.00 44.55  ? 27  PHE F O   1 
ATOM   1704 C CB  . PHE B 2 27  ? -26.934 20.995  28.209  1.00 39.37  ? 27  PHE F CB  1 
ATOM   1705 C CG  . PHE B 2 27  ? -27.257 19.649  27.626  1.00 37.84  ? 27  PHE F CG  1 
ATOM   1706 C CD1 . PHE B 2 27  ? -28.492 19.057  27.845  1.00 35.53  ? 27  PHE F CD1 1 
ATOM   1707 C CD2 . PHE B 2 27  ? -26.321 18.970  26.862  1.00 29.17  ? 27  PHE F CD2 1 
ATOM   1708 C CE1 . PHE B 2 27  ? -28.788 17.816  27.305  1.00 39.87  ? 27  PHE F CE1 1 
ATOM   1709 C CE2 . PHE B 2 27  ? -26.610 17.731  26.322  1.00 32.39  ? 27  PHE F CE2 1 
ATOM   1710 C CZ  . PHE B 2 27  ? -27.843 17.153  26.543  1.00 35.96  ? 27  PHE F CZ  1 
ATOM   1711 N N   . THR B 2 28  ? -25.554 22.398  25.856  1.00 42.36  ? 28  THR F N   1 
ATOM   1712 C CA  . THR B 2 28  ? -24.862 22.413  24.575  1.00 37.96  ? 28  THR F CA  1 
ATOM   1713 C C   . THR B 2 28  ? -24.367 21.008  24.255  1.00 38.86  ? 28  THR F C   1 
ATOM   1714 O O   . THR B 2 28  ? -23.627 20.411  25.044  1.00 48.72  ? 28  THR F O   1 
ATOM   1715 C CB  . THR B 2 28  ? -23.701 23.404  24.607  1.00 38.31  ? 28  THR F CB  1 
ATOM   1716 O OG1 . THR B 2 28  ? -24.204 24.711  24.912  1.00 37.08  ? 28  THR F OG1 1 
ATOM   1717 C CG2 . THR B 2 28  ? -22.993 23.437  23.266  1.00 30.62  ? 28  THR F CG2 1 
ATOM   1718 N N   . VAL B 2 29  ? -24.772 20.487  23.094  1.00 37.23  ? 29  VAL F N   1 
ATOM   1719 C CA  . VAL B 2 29  ? -24.401 19.127  22.707  1.00 34.23  ? 29  VAL F CA  1 
ATOM   1720 C C   . VAL B 2 29  ? -22.889 19.006  22.530  1.00 40.82  ? 29  VAL F C   1 
ATOM   1721 O O   . VAL B 2 29  ? -22.265 18.059  23.023  1.00 50.47  ? 29  VAL F O   1 
ATOM   1722 C CB  . VAL B 2 29  ? -25.156 18.712  21.429  1.00 42.68  ? 29  VAL F CB  1 
ATOM   1723 C CG1 . VAL B 2 29  ? -24.465 17.539  20.753  1.00 40.69  ? 29  VAL F CG1 1 
ATOM   1724 C CG2 . VAL B 2 29  ? -26.603 18.369  21.754  1.00 33.12  ? 29  VAL F CG2 1 
ATOM   1725 N N   . SER B 2 30  ? -22.277 19.967  21.830  1.00 42.16  ? 30  SER F N   1 
ATOM   1726 C CA  . SER B 2 30  ? -20.854 19.881  21.507  1.00 39.03  ? 30  SER F CA  1 
ATOM   1727 C C   . SER B 2 30  ? -19.960 19.911  22.736  1.00 39.26  ? 30  SER F C   1 
ATOM   1728 O O   . SER B 2 30  ? -18.822 19.433  22.672  1.00 49.87  ? 30  SER F O   1 
ATOM   1729 C CB  . SER B 2 30  ? -20.454 21.028  20.580  1.00 53.18  ? 30  SER F CB  1 
ATOM   1730 O OG  . SER B 2 30  ? -20.944 22.267  21.063  1.00 62.71  ? 30  SER F OG  1 
ATOM   1731 N N   . SER B 2 31  ? -20.436 20.464  23.845  1.00 34.35  ? 31  SER F N   1 
ATOM   1732 C CA  . SER B 2 31  ? -19.596 20.696  25.008  1.00 43.20  ? 31  SER F CA  1 
ATOM   1733 C C   . SER B 2 31  ? -19.765 19.637  26.089  1.00 49.63  ? 31  SER F C   1 
ATOM   1734 O O   . SER B 2 31  ? -19.171 19.767  27.163  1.00 50.64  ? 31  SER F O   1 
ATOM   1735 C CB  . SER B 2 31  ? -19.881 22.085  25.582  1.00 40.55  ? 31  SER F CB  1 
ATOM   1736 O OG  . SER B 2 31  ? -19.721 23.080  24.586  1.00 44.20  ? 31  SER F OG  1 
ATOM   1737 N N   . ASN B 2 32  ? -20.542 18.587  25.835  1.00 39.38  ? 32  ASN F N   1 
ATOM   1738 C CA  . ASN B 2 32  ? -20.854 17.612  26.868  1.00 45.34  ? 32  ASN F CA  1 
ATOM   1739 C C   . ASN B 2 32  ? -20.588 16.198  26.372  1.00 43.86  ? 32  ASN F C   1 
ATOM   1740 O O   . ASN B 2 32  ? -20.676 15.908  25.175  1.00 40.31  ? 32  ASN F O   1 
ATOM   1741 C CB  . ASN B 2 32  ? -22.320 17.738  27.338  1.00 36.82  ? 32  ASN F CB  1 
ATOM   1742 C CG  . ASN B 2 32  ? -22.567 18.986  28.179  1.00 43.31  ? 32  ASN F CG  1 
ATOM   1743 O OD1 . ASN B 2 32  ? -22.618 18.922  29.410  1.00 47.97  ? 32  ASN F OD1 1 
ATOM   1744 N ND2 . ASN B 2 32  ? -22.727 20.126  27.515  1.00 48.86  ? 32  ASN F ND2 1 
ATOM   1745 N N   . TYR B 2 33  ? -20.228 15.327  27.312  1.00 41.67  ? 33  TYR F N   1 
ATOM   1746 C CA  . TYR B 2 33  ? -20.212 13.897  27.051  1.00 29.82  ? 33  TYR F CA  1 
ATOM   1747 C C   . TYR B 2 33  ? -21.641 13.397  26.903  1.00 28.93  ? 33  TYR F C   1 
ATOM   1748 O O   . TYR B 2 33  ? -22.528 13.783  27.668  1.00 41.39  ? 33  TYR F O   1 
ATOM   1749 C CB  . TYR B 2 33  ? -19.534 13.144  28.196  1.00 37.76  ? 33  TYR F CB  1 
ATOM   1750 C CG  . TYR B 2 33  ? -18.085 13.486  28.471  1.00 36.69  ? 33  TYR F CG  1 
ATOM   1751 C CD1 . TYR B 2 33  ? -17.719 14.720  28.998  1.00 39.10  ? 33  TYR F CD1 1 
ATOM   1752 C CD2 . TYR B 2 33  ? -17.087 12.549  28.249  1.00 39.95  ? 33  TYR F CD2 1 
ATOM   1753 C CE1 . TYR B 2 33  ? -16.393 15.017  29.263  1.00 43.16  ? 33  TYR F CE1 1 
ATOM   1754 C CE2 . TYR B 2 33  ? -15.764 12.837  28.513  1.00 45.24  ? 33  TYR F CE2 1 
ATOM   1755 C CZ  . TYR B 2 33  ? -15.420 14.068  29.019  1.00 41.10  ? 33  TYR F CZ  1 
ATOM   1756 O OH  . TYR B 2 33  ? -14.095 14.339  29.277  1.00 42.08  ? 33  TYR F OH  1 
ATOM   1757 N N   . MET B 2 34  ? -21.871 12.532  25.921  1.00 27.26  ? 34  MET F N   1 
ATOM   1758 C CA  . MET B 2 34  ? -23.184 11.924  25.768  1.00 43.85  ? 34  MET F CA  1 
ATOM   1759 C C   . MET B 2 34  ? -23.031 10.475  25.334  1.00 37.09  ? 34  MET F C   1 
ATOM   1760 O O   . MET B 2 34  ? -22.148 10.147  24.537  1.00 38.62  ? 34  MET F O   1 
ATOM   1761 C CB  . MET B 2 34  ? -24.053 12.710  24.780  1.00 43.92  ? 34  MET F CB  1 
ATOM   1762 C CG  . MET B 2 34  ? -24.632 13.982  25.387  1.00 33.91  ? 34  MET F CG  1 
ATOM   1763 S SD  . MET B 2 34  ? -26.178 14.483  24.638  1.00 43.61  ? 34  MET F SD  1 
ATOM   1764 C CE  . MET B 2 34  ? -25.578 15.095  23.071  1.00 39.59  ? 34  MET F CE  1 
ATOM   1765 N N   . SER B 2 35  ? -23.891 9.611   25.877  1.00 34.49  ? 35  SER F N   1 
ATOM   1766 C CA  . SER B 2 35  ? -23.775 8.170   25.703  1.00 39.49  ? 35  SER F CA  1 
ATOM   1767 C C   . SER B 2 35  ? -25.120 7.559   25.332  1.00 39.32  ? 35  SER F C   1 
ATOM   1768 O O   . SER B 2 35  ? -26.182 8.087   25.677  1.00 30.16  ? 35  SER F O   1 
ATOM   1769 C CB  . SER B 2 35  ? -23.256 7.485   26.982  1.00 36.27  ? 35  SER F CB  1 
ATOM   1770 O OG  . SER B 2 35  ? -22.042 8.056   27.433  1.00 46.59  ? 35  SER F OG  1 
ATOM   1771 N N   . TRP B 2 36  ? -25.056 6.430   24.629  1.00 42.02  ? 36  TRP F N   1 
ATOM   1772 C CA  . TRP B 2 36  ? -26.213 5.589   24.347  1.00 39.28  ? 36  TRP F CA  1 
ATOM   1773 C C   . TRP B 2 36  ? -26.148 4.350   25.231  1.00 41.85  ? 36  TRP F C   1 
ATOM   1774 O O   . TRP B 2 36  ? -25.119 3.668   25.275  1.00 33.10  ? 36  TRP F O   1 
ATOM   1775 C CB  . TRP B 2 36  ? -26.259 5.178   22.872  1.00 39.03  ? 36  TRP F CB  1 
ATOM   1776 C CG  . TRP B 2 36  ? -26.638 6.284   21.923  1.00 40.17  ? 36  TRP F CG  1 
ATOM   1777 C CD1 . TRP B 2 36  ? -25.789 7.099   21.230  1.00 32.98  ? 36  TRP F CD1 1 
ATOM   1778 C CD2 . TRP B 2 36  ? -27.966 6.686   21.556  1.00 43.25  ? 36  TRP F CD2 1 
ATOM   1779 N NE1 . TRP B 2 36  ? -26.505 7.985   20.459  1.00 33.17  ? 36  TRP F NE1 1 
ATOM   1780 C CE2 . TRP B 2 36  ? -27.843 7.754   20.642  1.00 40.00  ? 36  TRP F CE2 1 
ATOM   1781 C CE3 . TRP B 2 36  ? -29.248 6.250   21.915  1.00 40.78  ? 36  TRP F CE3 1 
ATOM   1782 C CZ2 . TRP B 2 36  ? -28.951 8.390   20.083  1.00 35.74  ? 36  TRP F CZ2 1 
ATOM   1783 C CZ3 . TRP B 2 36  ? -30.349 6.885   21.357  1.00 33.86  ? 36  TRP F CZ3 1 
ATOM   1784 C CH2 . TRP B 2 36  ? -30.191 7.943   20.452  1.00 40.21  ? 36  TRP F CH2 1 
ATOM   1785 N N   . VAL B 2 37  ? -27.244 4.065   25.933  1.00 44.47  ? 37  VAL F N   1 
ATOM   1786 C CA  . VAL B 2 37  ? -27.358 2.901   26.805  1.00 40.31  ? 37  VAL F CA  1 
ATOM   1787 C C   . VAL B 2 37  ? -28.606 2.125   26.404  1.00 41.57  ? 37  VAL F C   1 
ATOM   1788 O O   . VAL B 2 37  ? -29.698 2.699   26.326  1.00 42.65  ? 37  VAL F O   1 
ATOM   1789 C CB  . VAL B 2 37  ? -27.426 3.307   28.291  1.00 41.30  ? 37  VAL F CB  1 
ATOM   1790 C CG1 . VAL B 2 37  ? -27.497 2.078   29.179  1.00 47.74  ? 37  VAL F CG1 1 
ATOM   1791 C CG2 . VAL B 2 37  ? -26.230 4.169   28.664  1.00 37.67  ? 37  VAL F CG2 1 
ATOM   1792 N N   . ARG B 2 38  ? -28.449 0.826   26.154  1.00 35.65  ? 38  ARG F N   1 
ATOM   1793 C CA  . ARG B 2 38  ? -29.554 -0.028  25.738  1.00 46.52  ? 38  ARG F CA  1 
ATOM   1794 C C   . ARG B 2 38  ? -29.974 -0.956  26.872  1.00 49.34  ? 38  ARG F C   1 
ATOM   1795 O O   . ARG B 2 38  ? -29.173 -1.307  27.742  1.00 46.41  ? 38  ARG F O   1 
ATOM   1796 C CB  . ARG B 2 38  ? -29.186 -0.857  24.503  1.00 42.87  ? 38  ARG F CB  1 
ATOM   1797 C CG  . ARG B 2 38  ? -28.165 -1.956  24.751  1.00 33.16  ? 38  ARG F CG  1 
ATOM   1798 C CD  . ARG B 2 38  ? -27.786 -2.634  23.445  1.00 36.93  ? 38  ARG F CD  1 
ATOM   1799 N NE  . ARG B 2 38  ? -26.764 -3.657  23.630  1.00 39.00  ? 38  ARG F NE  1 
ATOM   1800 C CZ  . ARG B 2 38  ? -26.213 -4.349  22.642  1.00 42.08  ? 38  ARG F CZ  1 
ATOM   1801 N NH1 . ARG B 2 38  ? -26.550 -4.141  21.380  1.00 35.56  ? 38  ARG F NH1 1 
ATOM   1802 N NH2 . ARG B 2 38  ? -25.302 -5.275  22.929  1.00 47.97  ? 38  ARG F NH2 1 
ATOM   1803 N N   . GLN B 2 39  ? -31.249 -1.351  26.848  1.00 48.40  ? 39  GLN F N   1 
ATOM   1804 C CA  . GLN B 2 39  ? -31.825 -2.227  27.871  1.00 46.46  ? 39  GLN F CA  1 
ATOM   1805 C C   . GLN B 2 39  ? -32.654 -3.297  27.168  1.00 51.31  ? 39  GLN F C   1 
ATOM   1806 O O   . GLN B 2 39  ? -33.769 -3.025  26.715  1.00 60.96  ? 39  GLN F O   1 
ATOM   1807 C CB  . GLN B 2 39  ? -32.672 -1.437  28.862  1.00 47.54  ? 39  GLN F CB  1 
ATOM   1808 C CG  . GLN B 2 39  ? -33.254 -2.280  29.991  1.00 48.47  ? 39  GLN F CG  1 
ATOM   1809 C CD  . GLN B 2 39  ? -34.087 -1.464  30.962  1.00 51.94  ? 39  GLN F CD  1 
ATOM   1810 O OE1 . GLN B 2 39  ? -34.580 -0.387  30.624  1.00 47.31  ? 39  GLN F OE1 1 
ATOM   1811 N NE2 . GLN B 2 39  ? -34.246 -1.973  32.178  1.00 44.08  ? 39  GLN F NE2 1 
ATOM   1812 N N   . ALA B 2 40  ? -32.107 -4.506  27.074  1.00 65.70  ? 40  ALA F N   1 
ATOM   1813 C CA  . ALA B 2 40  ? -32.846 -5.602  26.473  1.00 62.60  ? 40  ALA F CA  1 
ATOM   1814 C C   . ALA B 2 40  ? -34.016 -5.996  27.376  1.00 76.96  ? 40  ALA F C   1 
ATOM   1815 O O   . ALA B 2 40  ? -33.966 -5.790  28.592  1.00 80.34  ? 40  ALA F O   1 
ATOM   1816 C CB  . ALA B 2 40  ? -31.930 -6.800  26.235  1.00 49.05  ? 40  ALA F CB  1 
ATOM   1817 N N   . PRO B 2 41  ? -35.091 -6.539  26.803  1.00 86.21  ? 41  PRO F N   1 
ATOM   1818 C CA  . PRO B 2 41  ? -36.258 -6.903  27.623  1.00 85.20  ? 41  PRO F CA  1 
ATOM   1819 C C   . PRO B 2 41  ? -35.884 -7.913  28.698  1.00 88.04  ? 41  PRO F C   1 
ATOM   1820 O O   . PRO B 2 41  ? -35.454 -9.032  28.405  1.00 80.64  ? 41  PRO F O   1 
ATOM   1821 C CB  . PRO B 2 41  ? -37.238 -7.488  26.599  1.00 82.45  ? 41  PRO F CB  1 
ATOM   1822 C CG  . PRO B 2 41  ? -36.845 -6.847  25.302  1.00 63.96  ? 41  PRO F CG  1 
ATOM   1823 C CD  . PRO B 2 41  ? -35.350 -6.726  25.363  1.00 73.25  ? 41  PRO F CD  1 
ATOM   1824 N N   . GLY B 2 42  ? -36.029 -7.496  29.954  1.00 93.26  ? 42  GLY F N   1 
ATOM   1825 C CA  . GLY B 2 42  ? -35.721 -8.362  31.075  1.00 92.47  ? 42  GLY F CA  1 
ATOM   1826 C C   . GLY B 2 42  ? -34.254 -8.665  31.274  1.00 90.19  ? 42  GLY F C   1 
ATOM   1827 O O   . GLY B 2 42  ? -33.923 -9.659  31.924  1.00 96.85  ? 42  GLY F O   1 
ATOM   1828 N N   . LYS B 2 43  ? -33.359 -7.838  30.737  1.00 90.74  ? 43  LYS F N   1 
ATOM   1829 C CA  . LYS B 2 43  ? -31.924 -8.061  30.866  1.00 104.07 ? 43  LYS F CA  1 
ATOM   1830 C C   . LYS B 2 43  ? -31.202 -6.976  31.651  1.00 104.48 ? 43  LYS F C   1 
ATOM   1831 O O   . LYS B 2 43  ? -30.179 -7.265  32.277  1.00 98.91  ? 43  LYS F O   1 
ATOM   1832 C CB  . LYS B 2 43  ? -31.279 -8.196  29.474  1.00 89.55  ? 43  LYS F CB  1 
ATOM   1833 C CG  . LYS B 2 43  ? -29.818 -8.639  29.473  1.00 70.89  ? 43  LYS F CG  1 
ATOM   1834 C CD  . LYS B 2 43  ? -28.867 -7.452  29.372  1.00 75.34  ? 43  LYS F CD  1 
ATOM   1835 C CE  . LYS B 2 43  ? -27.418 -7.897  29.473  1.00 82.02  ? 43  LYS F CE  1 
ATOM   1836 N NZ  . LYS B 2 43  ? -26.467 -6.749  29.464  1.00 52.39  ? 43  LYS F NZ  1 
ATOM   1837 N N   . GLY B 2 44  ? -31.702 -5.746  31.645  1.00 88.49  ? 44  GLY F N   1 
ATOM   1838 C CA  . GLY B 2 44  ? -31.057 -4.657  32.351  1.00 75.84  ? 44  GLY F CA  1 
ATOM   1839 C C   . GLY B 2 44  ? -30.289 -3.748  31.413  1.00 71.57  ? 44  GLY F C   1 
ATOM   1840 O O   . GLY B 2 44  ? -30.243 -3.937  30.193  1.00 76.72  ? 44  GLY F O   1 
ATOM   1841 N N   . LEU B 2 45  ? -29.667 -2.740  32.015  1.00 61.40  ? 45  LEU F N   1 
ATOM   1842 C CA  . LEU B 2 45  ? -28.979 -1.707  31.258  1.00 41.33  ? 45  LEU F CA  1 
ATOM   1843 C C   . LEU B 2 45  ? -27.604 -2.186  30.804  1.00 39.57  ? 45  LEU F C   1 
ATOM   1844 O O   . LEU B 2 45  ? -26.945 -2.984  31.475  1.00 42.79  ? 45  LEU F O   1 
ATOM   1845 C CB  . LEU B 2 45  ? -28.850 -0.438  32.099  1.00 32.20  ? 45  LEU F CB  1 
ATOM   1846 C CG  . LEU B 2 45  ? -30.181 0.127   32.608  1.00 44.65  ? 45  LEU F CG  1 
ATOM   1847 C CD1 . LEU B 2 45  ? -29.962 1.243   33.618  1.00 51.72  ? 45  LEU F CD1 1 
ATOM   1848 C CD2 . LEU B 2 45  ? -31.040 0.618   31.451  1.00 40.57  ? 45  LEU F CD2 1 
ATOM   1849 N N   . GLU B 2 46  ? -27.183 -1.696  29.640  1.00 39.40  ? 46  GLU F N   1 
ATOM   1850 C CA  . GLU B 2 46  ? -25.866 -2.007  29.096  1.00 36.72  ? 46  GLU F CA  1 
ATOM   1851 C C   . GLU B 2 46  ? -25.348 -0.801  28.326  1.00 44.53  ? 46  GLU F C   1 
ATOM   1852 O O   . GLU B 2 46  ? -26.031 -0.295  27.432  1.00 48.40  ? 46  GLU F O   1 
ATOM   1853 C CB  . GLU B 2 46  ? -25.921 -3.236  28.183  1.00 31.50  ? 46  GLU F CB  1 
ATOM   1854 C CG  . GLU B 2 46  ? -24.615 -3.527  27.468  1.00 34.99  ? 46  GLU F CG  1 
ATOM   1855 C CD  . GLU B 2 46  ? -24.768 -4.554  26.362  1.00 53.25  ? 46  GLU F CD  1 
ATOM   1856 O OE1 . GLU B 2 46  ? -25.919 -4.860  25.983  1.00 47.18  ? 46  GLU F OE1 1 
ATOM   1857 O OE2 . GLU B 2 46  ? -23.734 -5.053  25.870  1.00 57.52  ? 46  GLU F OE2 1 
ATOM   1858 N N   . TRP B 2 47  ? -24.146 -0.346  28.675  1.00 42.85  ? 47  TRP F N   1 
ATOM   1859 C CA  . TRP B 2 47  ? -23.538 0.786   27.984  1.00 39.76  ? 47  TRP F CA  1 
ATOM   1860 C C   . TRP B 2 47  ? -23.118 0.393   26.570  1.00 40.30  ? 47  TRP F C   1 
ATOM   1861 O O   . TRP B 2 47  ? -22.582 -0.696  26.347  1.00 42.34  ? 47  TRP F O   1 
ATOM   1862 C CB  . TRP B 2 47  ? -22.331 1.298   28.771  1.00 42.83  ? 47  TRP F CB  1 
ATOM   1863 C CG  . TRP B 2 47  ? -21.556 2.350   28.047  1.00 37.04  ? 47  TRP F CG  1 
ATOM   1864 C CD1 . TRP B 2 47  ? -21.851 3.680   27.977  1.00 32.68  ? 47  TRP F CD1 1 
ATOM   1865 C CD2 . TRP B 2 47  ? -20.359 2.164   27.280  1.00 40.23  ? 47  TRP F CD2 1 
ATOM   1866 N NE1 . TRP B 2 47  ? -20.914 4.334   27.216  1.00 40.94  ? 47  TRP F NE1 1 
ATOM   1867 C CE2 . TRP B 2 47  ? -19.987 3.426   26.776  1.00 44.02  ? 47  TRP F CE2 1 
ATOM   1868 C CE3 . TRP B 2 47  ? -19.567 1.053   26.972  1.00 44.40  ? 47  TRP F CE3 1 
ATOM   1869 C CZ2 . TRP B 2 47  ? -18.855 3.608   25.980  1.00 34.75  ? 47  TRP F CZ2 1 
ATOM   1870 C CZ3 . TRP B 2 47  ? -18.441 1.237   26.180  1.00 44.27  ? 47  TRP F CZ3 1 
ATOM   1871 C CH2 . TRP B 2 47  ? -18.098 2.505   25.694  1.00 39.06  ? 47  TRP F CH2 1 
ATOM   1872 N N   . VAL B 2 48  ? -23.350 1.291   25.609  1.00 39.71  ? 48  VAL F N   1 
ATOM   1873 C CA  . VAL B 2 48  ? -23.098 1.021   24.191  1.00 33.63  ? 48  VAL F CA  1 
ATOM   1874 C C   . VAL B 2 48  ? -21.938 1.858   23.656  1.00 36.23  ? 48  VAL F C   1 
ATOM   1875 O O   . VAL B 2 48  ? -20.955 1.315   23.148  1.00 37.68  ? 48  VAL F O   1 
ATOM   1876 C CB  . VAL B 2 48  ? -24.372 1.234   23.344  1.00 31.35  ? 48  VAL F CB  1 
ATOM   1877 C CG1 . VAL B 2 48  ? -24.058 1.042   21.869  1.00 46.29  ? 48  VAL F CG1 1 
ATOM   1878 C CG2 . VAL B 2 48  ? -25.464 0.282   23.782  1.00 31.78  ? 48  VAL F CG2 1 
ATOM   1879 N N   . SER B 2 49  ? -22.049 3.184   23.731  1.00 47.71  ? 49  SER F N   1 
ATOM   1880 C CA  . SER B 2 49  ? -21.028 4.061   23.177  1.00 53.41  ? 49  SER F CA  1 
ATOM   1881 C C   . SER B 2 49  ? -21.059 5.400   23.896  1.00 44.71  ? 49  SER F C   1 
ATOM   1882 O O   . SER B 2 49  ? -22.022 5.737   24.586  1.00 44.16  ? 49  SER F O   1 
ATOM   1883 C CB  . SER B 2 49  ? -21.214 4.288   21.672  1.00 38.23  ? 49  SER F CB  1 
ATOM   1884 O OG  . SER B 2 49  ? -22.433 4.957   21.405  1.00 54.09  ? 49  SER F OG  1 
ATOM   1885 N N   . VAL B 2 50  ? -19.992 6.165   23.709  1.00 40.35  ? 50  VAL F N   1 
ATOM   1886 C CA  . VAL B 2 50  ? -19.885 7.495   24.284  1.00 35.35  ? 50  VAL F CA  1 
ATOM   1887 C C   . VAL B 2 50  ? -19.152 8.380   23.292  1.00 34.22  ? 50  VAL F C   1 
ATOM   1888 O O   . VAL B 2 50  ? -18.272 7.918   22.562  1.00 33.00  ? 50  VAL F O   1 
ATOM   1889 C CB  . VAL B 2 50  ? -19.166 7.466   25.650  1.00 38.14  ? 50  VAL F CB  1 
ATOM   1890 C CG1 . VAL B 2 50  ? -17.738 6.979   25.483  1.00 35.86  ? 50  VAL F CG1 1 
ATOM   1891 C CG2 . VAL B 2 50  ? -19.186 8.840   26.294  1.00 29.44  ? 50  VAL F CG2 1 
ATOM   1892 N N   . ILE B 2 51  ? -19.534 9.650   23.248  1.00 40.13  ? 51  ILE F N   1 
ATOM   1893 C CA  . ILE B 2 51  ? -18.809 10.657  22.488  1.00 37.34  ? 51  ILE F CA  1 
ATOM   1894 C C   . ILE B 2 51  ? -18.366 11.746  23.458  1.00 33.52  ? 51  ILE F C   1 
ATOM   1895 O O   . ILE B 2 51  ? -19.177 12.255  24.242  1.00 30.17  ? 51  ILE F O   1 
ATOM   1896 C CB  . ILE B 2 51  ? -19.661 11.226  21.339  1.00 34.74  ? 51  ILE F CB  1 
ATOM   1897 C CG1 . ILE B 2 51  ? -18.888 12.310  20.595  1.00 24.22  ? 51  ILE F CG1 1 
ATOM   1898 C CG2 . ILE B 2 51  ? -21.014 11.728  21.845  1.00 31.69  ? 51  ILE F CG2 1 
ATOM   1899 C CD1 . ILE B 2 51  ? -19.557 12.759  19.330  1.00 30.71  ? 51  ILE F CD1 1 
ATOM   1900 N N   . TYR B 2 52  ? -17.075 12.077  23.426  1.00 41.88  ? 52  TYR F N   1 
ATOM   1901 C CA  . TYR B 2 52  ? -16.506 13.050  24.348  1.00 32.70  ? 52  TYR F CA  1 
ATOM   1902 C C   . TYR B 2 52  ? -16.815 14.476  23.894  1.00 34.31  ? 52  TYR F C   1 
ATOM   1903 O O   . TYR B 2 52  ? -17.205 14.727  22.750  1.00 43.96  ? 52  TYR F O   1 
ATOM   1904 C CB  . TYR B 2 52  ? -14.989 12.867  24.476  1.00 35.60  ? 52  TYR F CB  1 
ATOM   1905 C CG  . TYR B 2 52  ? -14.550 11.711  25.357  1.00 43.97  ? 52  TYR F CG  1 
ATOM   1906 C CD1 . TYR B 2 52  ? -15.472 10.804  25.856  1.00 42.99  ? 52  TYR F CD1 1 
ATOM   1907 C CD2 . TYR B 2 52  ? -13.210 11.536  25.696  1.00 43.96  ? 52  TYR F CD2 1 
ATOM   1908 C CE1 . TYR B 2 52  ? -15.079 9.752   26.661  1.00 42.89  ? 52  TYR F CE1 1 
ATOM   1909 C CE2 . TYR B 2 52  ? -12.807 10.483  26.503  1.00 37.97  ? 52  TYR F CE2 1 
ATOM   1910 C CZ  . TYR B 2 52  ? -13.749 9.595   26.981  1.00 40.95  ? 52  TYR F CZ  1 
ATOM   1911 O OH  . TYR B 2 52  ? -13.367 8.544   27.785  1.00 44.40  ? 52  TYR F OH  1 
ATOM   1912 N N   . SER B 2 53  ? -16.622 15.425  24.816  1.00 37.53  ? 53  SER F N   1 
ATOM   1913 C CA  . SER B 2 53  ? -16.792 16.834  24.474  1.00 45.21  ? 53  SER F CA  1 
ATOM   1914 C C   . SER B 2 53  ? -15.836 17.257  23.366  1.00 35.65  ? 53  SER F C   1 
ATOM   1915 O O   . SER B 2 53  ? -16.170 18.129  22.556  1.00 42.27  ? 53  SER F O   1 
ATOM   1916 C CB  . SER B 2 53  ? -16.589 17.711  25.715  1.00 44.45  ? 53  SER F CB  1 
ATOM   1917 O OG  . SER B 2 53  ? -15.333 17.463  26.330  1.00 30.52  ? 53  SER F OG  1 
ATOM   1918 N N   . GLY B 2 54  ? -14.655 16.653  23.309  1.00 37.79  ? 54  GLY F N   1 
ATOM   1919 C CA  . GLY B 2 54  ? -13.693 16.947  22.271  1.00 44.10  ? 54  GLY F CA  1 
ATOM   1920 C C   . GLY B 2 54  ? -13.885 16.195  20.977  1.00 50.94  ? 54  GLY F C   1 
ATOM   1921 O O   . GLY B 2 54  ? -13.115 16.402  20.034  1.00 42.30  ? 54  GLY F O   1 
ATOM   1922 N N   . GLY B 2 55  ? -14.888 15.319  20.905  1.00 39.88  ? 55  GLY F N   1 
ATOM   1923 C CA  . GLY B 2 55  ? -15.193 14.585  19.696  1.00 38.56  ? 55  GLY F CA  1 
ATOM   1924 C C   . GLY B 2 55  ? -14.735 13.141  19.675  1.00 39.57  ? 55  GLY F C   1 
ATOM   1925 O O   . GLY B 2 55  ? -15.122 12.403  18.759  1.00 39.91  ? 55  GLY F O   1 
ATOM   1926 N N   . SER B 2 56  ? -13.921 12.715  20.637  1.00 36.81  ? 56  SER F N   1 
ATOM   1927 C CA  . SER B 2 56  ? -13.490 11.324  20.671  1.00 33.00  ? 56  SER F CA  1 
ATOM   1928 C C   . SER B 2 56  ? -14.680 10.407  20.922  1.00 36.39  ? 56  SER F C   1 
ATOM   1929 O O   . SER B 2 56  ? -15.597 10.743  21.676  1.00 35.28  ? 56  SER F O   1 
ATOM   1930 C CB  . SER B 2 56  ? -12.428 11.116  21.748  1.00 27.49  ? 56  SER F CB  1 
ATOM   1931 O OG  . SER B 2 56  ? -11.264 11.865  21.456  1.00 40.70  ? 56  SER F OG  1 
ATOM   1932 N N   . THR B 2 57  ? -14.668 9.245   20.275  1.00 30.77  ? 57  THR F N   1 
ATOM   1933 C CA  . THR B 2 57  ? -15.749 8.277   20.387  1.00 38.07  ? 57  THR F CA  1 
ATOM   1934 C C   . THR B 2 57  ? -15.202 6.941   20.866  1.00 43.48  ? 57  THR F C   1 
ATOM   1935 O O   . THR B 2 57  ? -14.124 6.510   20.443  1.00 50.36  ? 57  THR F O   1 
ATOM   1936 C CB  . THR B 2 57  ? -16.474 8.086   19.050  1.00 34.46  ? 57  THR F CB  1 
ATOM   1937 O OG1 . THR B 2 57  ? -15.541 7.645   18.057  1.00 40.45  ? 57  THR F OG1 1 
ATOM   1938 C CG2 . THR B 2 57  ? -17.108 9.389   18.599  1.00 39.37  ? 57  THR F CG2 1 
ATOM   1939 N N   . PHE B 2 58  ? -15.950 6.295   21.753  1.00 41.21  ? 58  PHE F N   1 
ATOM   1940 C CA  . PHE B 2 58  ? -15.616 4.970   22.247  1.00 45.24  ? 58  PHE F CA  1 
ATOM   1941 C C   . PHE B 2 58  ? -16.870 4.108   22.249  1.00 51.67  ? 58  PHE F C   1 
ATOM   1942 O O   . PHE B 2 58  ? -17.984 4.606   22.435  1.00 51.83  ? 58  PHE F O   1 
ATOM   1943 C CB  . PHE B 2 58  ? -15.009 5.035   23.648  1.00 42.33  ? 58  PHE F CB  1 
ATOM   1944 C CG  . PHE B 2 58  ? -13.758 5.859   23.720  1.00 34.74  ? 58  PHE F CG  1 
ATOM   1945 C CD1 . PHE B 2 58  ? -12.524 5.288   23.478  1.00 24.89  ? 58  PHE F CD1 1 
ATOM   1946 C CD2 . PHE B 2 58  ? -13.820 7.210   24.014  1.00 44.99  ? 58  PHE F CD2 1 
ATOM   1947 C CE1 . PHE B 2 58  ? -11.372 6.043   23.537  1.00 33.73  ? 58  PHE F CE1 1 
ATOM   1948 C CE2 . PHE B 2 58  ? -12.672 7.974   24.075  1.00 46.17  ? 58  PHE F CE2 1 
ATOM   1949 C CZ  . PHE B 2 58  ? -11.444 7.388   23.835  1.00 47.71  ? 58  PHE F CZ  1 
ATOM   1950 N N   . TYR B 2 59  ? -16.677 2.809   22.037  1.00 51.37  ? 59  TYR F N   1 
ATOM   1951 C CA  . TYR B 2 59  ? -17.775 1.873   21.859  1.00 49.26  ? 59  TYR F CA  1 
ATOM   1952 C C   . TYR B 2 59  ? -17.542 0.636   22.715  1.00 51.65  ? 59  TYR F C   1 
ATOM   1953 O O   . TYR B 2 59  ? -16.441 0.393   23.217  1.00 49.42  ? 59  TYR F O   1 
ATOM   1954 C CB  . TYR B 2 59  ? -17.931 1.475   20.383  1.00 41.51  ? 59  TYR F CB  1 
ATOM   1955 C CG  . TYR B 2 59  ? -18.122 2.647   19.446  1.00 41.14  ? 59  TYR F CG  1 
ATOM   1956 C CD1 . TYR B 2 59  ? -17.031 3.325   18.918  1.00 33.31  ? 59  TYR F CD1 1 
ATOM   1957 C CD2 . TYR B 2 59  ? -19.393 3.071   19.084  1.00 45.07  ? 59  TYR F CD2 1 
ATOM   1958 C CE1 . TYR B 2 59  ? -17.201 4.398   18.061  1.00 39.60  ? 59  TYR F CE1 1 
ATOM   1959 C CE2 . TYR B 2 59  ? -19.574 4.143   18.229  1.00 47.02  ? 59  TYR F CE2 1 
ATOM   1960 C CZ  . TYR B 2 59  ? -18.475 4.802   17.719  1.00 44.51  ? 59  TYR F CZ  1 
ATOM   1961 O OH  . TYR B 2 59  ? -18.653 5.868   16.866  1.00 47.62  ? 59  TYR F OH  1 
ATOM   1962 N N   . ALA B 2 60  ? -18.604 -0.146  22.881  1.00 53.64  ? 60  ALA F N   1 
ATOM   1963 C CA  . ALA B 2 60  ? -18.517 -1.418  23.578  1.00 44.59  ? 60  ALA F CA  1 
ATOM   1964 C C   . ALA B 2 60  ? -18.028 -2.512  22.631  1.00 51.63  ? 60  ALA F C   1 
ATOM   1965 O O   . ALA B 2 60  ? -18.109 -2.391  21.406  1.00 49.08  ? 60  ALA F O   1 
ATOM   1966 C CB  . ALA B 2 60  ? -19.873 -1.799  24.174  1.00 33.17  ? 60  ALA F CB  1 
ATOM   1967 N N   . ASP B 2 61  ? -17.516 -3.597  23.223  1.00 57.64  ? 61  ASP F N   1 
ATOM   1968 C CA  . ASP B 2 61  ? -16.972 -4.695  22.425  1.00 61.83  ? 61  ASP F CA  1 
ATOM   1969 C C   . ASP B 2 61  ? -18.045 -5.329  21.548  1.00 59.99  ? 61  ASP F C   1 
ATOM   1970 O O   . ASP B 2 61  ? -17.797 -5.639  20.376  1.00 58.54  ? 61  ASP F O   1 
ATOM   1971 C CB  . ASP B 2 61  ? -16.340 -5.748  23.339  1.00 84.56  ? 61  ASP F CB  1 
ATOM   1972 C CG  . ASP B 2 61  ? -15.003 -5.307  23.910  1.00 86.36  ? 61  ASP F CG  1 
ATOM   1973 O OD1 . ASP B 2 61  ? -14.214 -4.682  23.170  1.00 90.33  ? 61  ASP F OD1 1 
ATOM   1974 O OD2 . ASP B 2 61  ? -14.739 -5.589  25.099  1.00 82.78  ? 61  ASP F OD2 1 
ATOM   1975 N N   . SER B 2 62  ? -19.247 -5.519  22.096  1.00 50.53  ? 62  SER F N   1 
ATOM   1976 C CA  . SER B 2 62  ? -20.325 -6.160  21.354  1.00 47.24  ? 62  SER F CA  1 
ATOM   1977 C C   . SER B 2 62  ? -20.825 -5.318  20.184  1.00 45.96  ? 62  SER F C   1 
ATOM   1978 O O   . SER B 2 62  ? -21.453 -5.865  19.271  1.00 59.45  ? 62  SER F O   1 
ATOM   1979 C CB  . SER B 2 62  ? -21.486 -6.483  22.298  1.00 55.88  ? 62  SER F CB  1 
ATOM   1980 O OG  . SER B 2 62  ? -21.888 -5.336  23.029  1.00 40.50  ? 62  SER F OG  1 
ATOM   1981 N N   . VAL B 2 63  ? -20.562 -4.013  20.177  1.00 51.38  ? 63  VAL F N   1 
ATOM   1982 C CA  . VAL B 2 63  ? -21.056 -3.131  19.128  1.00 44.84  ? 63  VAL F CA  1 
ATOM   1983 C C   . VAL B 2 63  ? -19.940 -2.461  18.344  1.00 39.18  ? 63  VAL F C   1 
ATOM   1984 O O   . VAL B 2 63  ? -20.225 -1.756  17.372  1.00 45.01  ? 63  VAL F O   1 
ATOM   1985 C CB  . VAL B 2 63  ? -22.015 -2.067  19.696  1.00 40.95  ? 63  VAL F CB  1 
ATOM   1986 C CG1 . VAL B 2 63  ? -23.177 -2.739  20.402  1.00 38.01  ? 63  VAL F CG1 1 
ATOM   1987 C CG2 . VAL B 2 63  ? -21.273 -1.131  20.638  1.00 51.17  ? 63  VAL F CG2 1 
ATOM   1988 N N   . LYS B 2 64  ? -18.682 -2.656  18.731  1.00 47.15  ? 64  LYS F N   1 
ATOM   1989 C CA  . LYS B 2 64  ? -17.578 -2.025  18.020  1.00 50.81  ? 64  LYS F CA  1 
ATOM   1990 C C   . LYS B 2 64  ? -17.494 -2.550  16.594  1.00 47.80  ? 64  LYS F C   1 
ATOM   1991 O O   . LYS B 2 64  ? -17.686 -3.742  16.338  1.00 60.89  ? 64  LYS F O   1 
ATOM   1992 C CB  . LYS B 2 64  ? -16.259 -2.276  18.751  1.00 57.23  ? 64  LYS F CB  1 
ATOM   1993 C CG  . LYS B 2 64  ? -15.548 -1.006  19.194  1.00 64.80  ? 64  LYS F CG  1 
ATOM   1994 C CD  . LYS B 2 64  ? -14.350 -1.308  20.088  1.00 81.64  ? 64  LYS F CD  1 
ATOM   1995 C CE  . LYS B 2 64  ? -14.768 -2.011  21.375  1.00 69.07  ? 64  LYS F CE  1 
ATOM   1996 N NZ  . LYS B 2 64  ? -13.655 -2.113  22.366  1.00 66.36  ? 64  LYS F NZ  1 
ATOM   1997 N N   . GLY B 2 65  ? -17.215 -1.646  15.659  1.00 36.80  ? 65  GLY F N   1 
ATOM   1998 C CA  . GLY B 2 65  ? -17.148 -1.995  14.259  1.00 39.91  ? 65  GLY F CA  1 
ATOM   1999 C C   . GLY B 2 65  ? -18.479 -2.012  13.545  1.00 52.88  ? 65  GLY F C   1 
ATOM   2000 O O   . GLY B 2 65  ? -18.500 -2.102  12.311  1.00 56.57  ? 65  GLY F O   1 
ATOM   2001 N N   . ARG B 2 66  ? -19.587 -1.927  14.272  1.00 49.37  ? 66  ARG F N   1 
ATOM   2002 C CA  . ARG B 2 66  ? -20.921 -1.898  13.688  1.00 51.40  ? 66  ARG F CA  1 
ATOM   2003 C C   . ARG B 2 66  ? -21.679 -0.620  14.002  1.00 51.36  ? 66  ARG F C   1 
ATOM   2004 O O   . ARG B 2 66  ? -22.413 -0.118  13.147  1.00 52.39  ? 66  ARG F O   1 
ATOM   2005 C CB  . ARG B 2 66  ? -21.734 -3.108  14.173  1.00 46.12  ? 66  ARG F CB  1 
ATOM   2006 C CG  . ARG B 2 66  ? -21.052 -4.439  13.915  1.00 47.42  ? 66  ARG F CG  1 
ATOM   2007 C CD  . ARG B 2 66  ? -21.909 -5.617  14.340  1.00 47.99  ? 66  ARG F CD  1 
ATOM   2008 N NE  . ARG B 2 66  ? -22.250 -5.583  15.758  1.00 47.20  ? 66  ARG F NE  1 
ATOM   2009 C CZ  . ARG B 2 66  ? -23.475 -5.388  16.228  1.00 36.87  ? 66  ARG F CZ  1 
ATOM   2010 N NH1 . ARG B 2 66  ? -24.502 -5.198  15.418  1.00 44.98  ? 66  ARG F NH1 1 
ATOM   2011 N NH2 . ARG B 2 66  ? -23.676 -5.395  17.543  1.00 29.62  ? 66  ARG F NH2 1 
ATOM   2012 N N   . PHE B 2 67  ? -21.516 -0.074  15.203  1.00 48.20  ? 67  PHE F N   1 
ATOM   2013 C CA  . PHE B 2 67  ? -22.211 1.134   15.617  1.00 44.60  ? 67  PHE F CA  1 
ATOM   2014 C C   . PHE B 2 67  ? -21.300 2.346   15.465  1.00 52.28  ? 67  PHE F C   1 
ATOM   2015 O O   . PHE B 2 67  ? -20.080 2.257   15.630  1.00 53.44  ? 67  PHE F O   1 
ATOM   2016 C CB  . PHE B 2 67  ? -22.693 1.030   17.068  1.00 51.20  ? 67  PHE F CB  1 
ATOM   2017 C CG  . PHE B 2 67  ? -23.859 0.094   17.268  1.00 50.72  ? 67  PHE F CG  1 
ATOM   2018 C CD1 . PHE B 2 67  ? -24.289 -0.745  16.252  1.00 49.07  ? 67  PHE F CD1 1 
ATOM   2019 C CD2 . PHE B 2 67  ? -24.533 0.068   18.478  1.00 47.58  ? 67  PHE F CD2 1 
ATOM   2020 C CE1 . PHE B 2 67  ? -25.358 -1.601  16.444  1.00 49.99  ? 67  PHE F CE1 1 
ATOM   2021 C CE2 . PHE B 2 67  ? -25.606 -0.785  18.675  1.00 52.44  ? 67  PHE F CE2 1 
ATOM   2022 C CZ  . PHE B 2 67  ? -26.019 -1.620  17.657  1.00 44.32  ? 67  PHE F CZ  1 
ATOM   2023 N N   . THR B 2 68  ? -21.910 3.486   15.146  1.00 52.75  ? 68  THR F N   1 
ATOM   2024 C CA  . THR B 2 68  ? -21.189 4.744   14.984  1.00 43.82  ? 68  THR F CA  1 
ATOM   2025 C C   . THR B 2 68  ? -21.981 5.848   15.666  1.00 46.04  ? 68  THR F C   1 
ATOM   2026 O O   . THR B 2 68  ? -23.121 6.121   15.279  1.00 50.26  ? 68  THR F O   1 
ATOM   2027 C CB  . THR B 2 68  ? -20.980 5.080   13.505  1.00 39.90  ? 68  THR F CB  1 
ATOM   2028 O OG1 . THR B 2 68  ? -20.276 4.010   12.862  1.00 48.38  ? 68  THR F OG1 1 
ATOM   2029 C CG2 . THR B 2 68  ? -20.180 6.363   13.365  1.00 39.43  ? 68  THR F CG2 1 
ATOM   2030 N N   . ILE B 2 69  ? -21.380 6.486   16.665  1.00 43.16  ? 69  ILE F N   1 
ATOM   2031 C CA  . ILE B 2 69  ? -22.022 7.565   17.406  1.00 40.44  ? 69  ILE F CA  1 
ATOM   2032 C C   . ILE B 2 69  ? -21.522 8.897   16.865  1.00 44.36  ? 69  ILE F C   1 
ATOM   2033 O O   . ILE B 2 69  ? -20.335 9.048   16.549  1.00 46.19  ? 69  ILE F O   1 
ATOM   2034 C CB  . ILE B 2 69  ? -21.763 7.433   18.920  1.00 38.29  ? 69  ILE F CB  1 
ATOM   2035 C CG1 . ILE B 2 69  ? -22.551 8.484   19.698  1.00 39.23  ? 69  ILE F CG1 1 
ATOM   2036 C CG2 . ILE B 2 69  ? -20.281 7.545   19.237  1.00 41.10  ? 69  ILE F CG2 1 
ATOM   2037 C CD1 . ILE B 2 69  ? -22.507 8.275   21.193  1.00 36.87  ? 69  ILE F CD1 1 
ATOM   2038 N N   . SER B 2 70  ? -22.434 9.858   16.727  1.00 43.04  ? 70  SER F N   1 
ATOM   2039 C CA  . SER B 2 70  ? -22.094 11.150  16.148  1.00 35.24  ? 70  SER F CA  1 
ATOM   2040 C C   . SER B 2 70  ? -23.082 12.196  16.640  1.00 34.92  ? 70  SER F C   1 
ATOM   2041 O O   . SER B 2 70  ? -24.161 11.873  17.145  1.00 36.19  ? 70  SER F O   1 
ATOM   2042 C CB  . SER B 2 70  ? -22.088 11.097  14.617  1.00 39.72  ? 70  SER F CB  1 
ATOM   2043 O OG  . SER B 2 70  ? -23.349 10.700  14.111  1.00 43.38  ? 70  SER F OG  1 
ATOM   2044 N N   . ARG B 2 71  ? -22.697 13.459  16.476  1.00 37.69  ? 71  ARG F N   1 
ATOM   2045 C CA  . ARG B 2 71  ? -23.491 14.590  16.927  1.00 37.49  ? 71  ARG F CA  1 
ATOM   2046 C C   . ARG B 2 71  ? -23.650 15.589  15.789  1.00 36.21  ? 71  ARG F C   1 
ATOM   2047 O O   . ARG B 2 71  ? -22.780 15.707  14.921  1.00 38.67  ? 71  ARG F O   1 
ATOM   2048 C CB  . ARG B 2 71  ? -22.846 15.278  18.142  1.00 31.85  ? 71  ARG F CB  1 
ATOM   2049 C CG  . ARG B 2 71  ? -21.456 15.838  17.867  1.00 34.44  ? 71  ARG F CG  1 
ATOM   2050 C CD  . ARG B 2 71  ? -21.060 16.859  18.916  1.00 45.20  ? 71  ARG F CD  1 
ATOM   2051 N NE  . ARG B 2 71  ? -20.713 16.240  20.187  1.00 39.46  ? 71  ARG F NE  1 
ATOM   2052 C CZ  . ARG B 2 71  ? -19.484 16.191  20.682  1.00 41.66  ? 71  ARG F CZ  1 
ATOM   2053 N NH1 . ARG B 2 71  ? -18.459 16.734  20.042  1.00 32.42  ? 71  ARG F NH1 1 
ATOM   2054 N NH2 . ARG B 2 71  ? -19.279 15.592  21.851  1.00 40.16  ? 71  ARG F NH2 1 
ATOM   2055 N N   . ASP B 2 72  ? -24.778 16.297  15.791  1.00 44.43  ? 72  ASP F N   1 
ATOM   2056 C CA  . ASP B 2 72  ? -25.046 17.375  14.840  1.00 44.30  ? 72  ASP F CA  1 
ATOM   2057 C C   . ASP B 2 72  ? -25.324 18.630  15.658  1.00 50.65  ? 72  ASP F C   1 
ATOM   2058 O O   . ASP B 2 72  ? -26.436 18.823  16.159  1.00 46.48  ? 72  ASP F O   1 
ATOM   2059 C CB  . ASP B 2 72  ? -26.213 17.039  13.916  1.00 49.53  ? 72  ASP F CB  1 
ATOM   2060 C CG  . ASP B 2 72  ? -26.206 17.865  12.633  1.00 59.04  ? 72  ASP F CG  1 
ATOM   2061 O OD1 . ASP B 2 72  ? -25.774 19.038  12.666  1.00 63.93  ? 72  ASP F OD1 1 
ATOM   2062 O OD2 . ASP B 2 72  ? -26.638 17.337  11.587  1.00 66.22  ? 72  ASP F OD2 1 
ATOM   2063 N N   . ASN B 2 73  ? -24.305 19.478  15.788  1.00 55.02  ? 73  ASN F N   1 
ATOM   2064 C CA  . ASN B 2 73  ? -24.438 20.686  16.592  1.00 57.77  ? 73  ASN F CA  1 
ATOM   2065 C C   . ASN B 2 73  ? -25.483 21.627  16.003  1.00 52.96  ? 73  ASN F C   1 
ATOM   2066 O O   . ASN B 2 73  ? -26.263 22.241  16.740  1.00 43.42  ? 73  ASN F O   1 
ATOM   2067 C CB  . ASN B 2 73  ? -23.077 21.367  16.698  1.00 60.96  ? 73  ASN F CB  1 
ATOM   2068 C CG  . ASN B 2 73  ? -21.934 20.368  16.666  1.00 70.75  ? 73  ASN F CG  1 
ATOM   2069 O OD1 . ASN B 2 73  ? -21.468 19.973  15.597  1.00 71.52  ? 73  ASN F OD1 1 
ATOM   2070 N ND2 . ASN B 2 73  ? -21.490 19.939  17.840  1.00 65.32  ? 73  ASN F ND2 1 
ATOM   2071 N N   . SER B 2 74  ? -25.520 21.736  14.672  1.00 59.79  ? 74  SER F N   1 
ATOM   2072 C CA  . SER B 2 74  ? -26.472 22.622  14.009  1.00 55.25  ? 74  SER F CA  1 
ATOM   2073 C C   . SER B 2 74  ? -27.915 22.262  14.341  1.00 55.33  ? 74  SER F C   1 
ATOM   2074 O O   . SER B 2 74  ? -28.788 23.138  14.353  1.00 54.19  ? 74  SER F O   1 
ATOM   2075 C CB  . SER B 2 74  ? -26.246 22.580  12.496  1.00 65.19  ? 74  SER F CB  1 
ATOM   2076 O OG  . SER B 2 74  ? -27.415 22.948  11.782  1.00 63.34  ? 74  SER F OG  1 
ATOM   2077 N N   . LYS B 2 75  ? -28.189 20.989  14.614  1.00 57.72  ? 75  LYS F N   1 
ATOM   2078 C CA  . LYS B 2 75  ? -29.544 20.529  14.873  1.00 44.16  ? 75  LYS F CA  1 
ATOM   2079 C C   . LYS B 2 75  ? -29.734 20.037  16.301  1.00 46.10  ? 75  LYS F C   1 
ATOM   2080 O O   . LYS B 2 75  ? -30.837 19.600  16.649  1.00 33.77  ? 75  LYS F O   1 
ATOM   2081 C CB  . LYS B 2 75  ? -29.915 19.432  13.865  1.00 39.63  ? 75  LYS F CB  1 
ATOM   2082 C CG  . LYS B 2 75  ? -29.087 19.528  12.579  1.00 71.86  ? 75  LYS F CG  1 
ATOM   2083 C CD  . LYS B 2 75  ? -29.875 19.231  11.308  1.00 66.64  ? 75  LYS F CD  1 
ATOM   2084 C CE  . LYS B 2 75  ? -29.044 19.557  10.059  1.00 60.98  ? 75  LYS F CE  1 
ATOM   2085 N NZ  . LYS B 2 75  ? -28.763 21.021  9.896   1.00 45.14  ? 75  LYS F NZ  1 
ATOM   2086 N N   . SER B 2 76  ? -28.696 20.114  17.137  1.00 56.07  ? 76  SER F N   1 
ATOM   2087 C CA  . SER B 2 76  ? -28.787 19.765  18.555  1.00 45.68  ? 76  SER F CA  1 
ATOM   2088 C C   . SER B 2 76  ? -29.317 18.344  18.741  1.00 48.00  ? 76  SER F C   1 
ATOM   2089 O O   . SER B 2 76  ? -30.204 18.085  19.558  1.00 40.51  ? 76  SER F O   1 
ATOM   2090 C CB  . SER B 2 76  ? -29.650 20.780  19.306  1.00 34.74  ? 76  SER F CB  1 
ATOM   2091 O OG  . SER B 2 76  ? -29.740 20.457  20.681  1.00 40.93  ? 76  SER F OG  1 
ATOM   2092 N N   . THR B 2 77  ? -28.766 17.416  17.960  1.00 48.82  ? 77  THR F N   1 
ATOM   2093 C CA  . THR B 2 77  ? -29.210 16.030  17.958  1.00 45.67  ? 77  THR F CA  1 
ATOM   2094 C C   . THR B 2 77  ? -28.006 15.101  18.041  1.00 38.40  ? 77  THR F C   1 
ATOM   2095 O O   . THR B 2 77  ? -26.975 15.349  17.408  1.00 38.06  ? 77  THR F O   1 
ATOM   2096 C CB  . THR B 2 77  ? -30.047 15.716  16.697  1.00 45.60  ? 77  THR F CB  1 
ATOM   2097 O OG1 . THR B 2 77  ? -31.203 16.561  16.667  1.00 43.32  ? 77  THR F OG1 1 
ATOM   2098 C CG2 . THR B 2 77  ? -30.501 14.266  16.685  1.00 46.10  ? 77  THR F CG2 1 
ATOM   2099 N N   . LEU B 2 78  ? -28.139 14.044  18.840  1.00 36.29  ? 78  LEU F N   1 
ATOM   2100 C CA  . LEU B 2 78  ? -27.140 12.988  18.943  1.00 31.47  ? 78  LEU F CA  1 
ATOM   2101 C C   . LEU B 2 78  ? -27.610 11.782  18.138  1.00 39.82  ? 78  LEU F C   1 
ATOM   2102 O O   . LEU B 2 78  ? -28.769 11.369  18.252  1.00 37.18  ? 78  LEU F O   1 
ATOM   2103 C CB  . LEU B 2 78  ? -26.909 12.592  20.402  1.00 25.38  ? 78  LEU F CB  1 
ATOM   2104 C CG  . LEU B 2 78  ? -25.857 11.516  20.664  1.00 30.18  ? 78  LEU F CG  1 
ATOM   2105 C CD1 . LEU B 2 78  ? -24.471 12.050  20.372  1.00 31.97  ? 78  LEU F CD1 1 
ATOM   2106 C CD2 . LEU B 2 78  ? -25.946 11.021  22.094  1.00 33.28  ? 78  LEU F CD2 1 
ATOM   2107 N N   . TYR B 2 79  ? -26.716 11.226  17.329  1.00 39.96  ? 79  TYR F N   1 
ATOM   2108 C CA  . TYR B 2 79  ? -27.058 10.141  16.425  1.00 37.21  ? 79  TYR F CA  1 
ATOM   2109 C C   . TYR B 2 79  ? -26.378 8.847   16.848  1.00 41.34  ? 79  TYR F C   1 
ATOM   2110 O O   . TYR B 2 79  ? -25.349 8.847   17.528  1.00 43.37  ? 79  TYR F O   1 
ATOM   2111 C CB  . TYR B 2 79  ? -26.665 10.478  14.984  1.00 30.17  ? 79  TYR F CB  1 
ATOM   2112 C CG  . TYR B 2 79  ? -27.467 11.602  14.373  1.00 41.87  ? 79  TYR F CG  1 
ATOM   2113 C CD1 . TYR B 2 79  ? -28.786 11.408  13.984  1.00 47.10  ? 79  TYR F CD1 1 
ATOM   2114 C CD2 . TYR B 2 79  ? -26.904 12.854  14.180  1.00 35.73  ? 79  TYR F CD2 1 
ATOM   2115 C CE1 . TYR B 2 79  ? -29.524 12.436  13.424  1.00 51.07  ? 79  TYR F CE1 1 
ATOM   2116 C CE2 . TYR B 2 79  ? -27.633 13.886  13.621  1.00 44.76  ? 79  TYR F CE2 1 
ATOM   2117 C CZ  . TYR B 2 79  ? -28.940 13.674  13.245  1.00 55.54  ? 79  TYR F CZ  1 
ATOM   2118 O OH  . TYR B 2 79  ? -29.659 14.708  12.688  1.00 70.38  ? 79  TYR F OH  1 
ATOM   2119 N N   . LEU B 2 80  ? -26.971 7.732   16.425  1.00 48.66  ? 80  LEU F N   1 
ATOM   2120 C CA  . LEU B 2 80  ? -26.362 6.419   16.624  1.00 36.89  ? 80  LEU F CA  1 
ATOM   2121 C C   . LEU B 2 80  ? -26.683 5.575   15.392  1.00 35.78  ? 80  LEU F C   1 
ATOM   2122 O O   . LEU B 2 80  ? -27.811 5.098   15.243  1.00 44.21  ? 80  LEU F O   1 
ATOM   2123 C CB  . LEU B 2 80  ? -26.865 5.763   17.903  1.00 36.15  ? 80  LEU F CB  1 
ATOM   2124 C CG  . LEU B 2 80  ? -26.366 4.341   18.152  1.00 37.10  ? 80  LEU F CG  1 
ATOM   2125 C CD1 . LEU B 2 80  ? -24.857 4.341   18.316  1.00 43.19  ? 80  LEU F CD1 1 
ATOM   2126 C CD2 . LEU B 2 80  ? -27.047 3.717   19.365  1.00 38.51  ? 80  LEU F CD2 1 
ATOM   2127 N N   . GLN B 2 81  ? -25.698 5.421   14.508  1.00 43.77  ? 81  GLN F N   1 
ATOM   2128 C CA  . GLN B 2 81  ? -25.846 4.561   13.340  1.00 43.01  ? 81  GLN F CA  1 
ATOM   2129 C C   . GLN B 2 81  ? -25.615 3.110   13.744  1.00 49.91  ? 81  GLN F C   1 
ATOM   2130 O O   . GLN B 2 81  ? -24.653 2.801   14.453  1.00 56.55  ? 81  GLN F O   1 
ATOM   2131 C CB  . GLN B 2 81  ? -24.860 4.965   12.241  1.00 38.19  ? 81  GLN F CB  1 
ATOM   2132 C CG  . GLN B 2 81  ? -25.054 4.220   10.924  1.00 44.85  ? 81  GLN F CG  1 
ATOM   2133 C CD  . GLN B 2 81  ? -26.372 4.559   10.251  1.00 63.09  ? 81  GLN F CD  1 
ATOM   2134 O OE1 . GLN B 2 81  ? -26.773 5.723   10.196  1.00 53.59  ? 81  GLN F OE1 1 
ATOM   2135 N NE2 . GLN B 2 81  ? -27.056 3.541   9.741   1.00 59.96  ? 81  GLN F NE2 1 
ATOM   2136 N N   . MET B 2 82  ? -26.492 2.217   13.286  1.00 45.21  ? 82  MET F N   1 
ATOM   2137 C CA  . MET B 2 82  ? -26.444 0.804   13.663  1.00 43.87  ? 82  MET F CA  1 
ATOM   2138 C C   . MET B 2 82  ? -26.423 -0.042  12.394  1.00 49.20  ? 82  MET F C   1 
ATOM   2139 O O   . MET B 2 82  ? -27.473 -0.441  11.886  1.00 61.39  ? 82  MET F O   1 
ATOM   2140 C CB  . MET B 2 82  ? -27.622 0.445   14.561  1.00 36.70  ? 82  MET F CB  1 
ATOM   2141 C CG  . MET B 2 82  ? -27.729 1.322   15.792  1.00 35.60  ? 82  MET F CG  1 
ATOM   2142 S SD  . MET B 2 82  ? -28.872 0.665   17.021  1.00 58.86  ? 82  MET F SD  1 
ATOM   2143 C CE  . MET B 2 82  ? -30.406 0.728   16.111  1.00 37.08  ? 82  MET F CE  1 
ATOM   2144 N N   . ASN B 2 83  A -25.226 -0.323  11.891  1.00 51.60  ? 82  ASN F N   1 
ATOM   2145 C CA  . ASN B 2 83  A -25.068 -1.163  10.715  1.00 55.31  ? 82  ASN F CA  1 
ATOM   2146 C C   . ASN B 2 83  A -24.856 -2.614  11.127  1.00 59.16  ? 82  ASN F C   1 
ATOM   2147 O O   . ASN B 2 83  A -24.398 -2.903  12.237  1.00 60.17  ? 82  ASN F O   1 
ATOM   2148 C CB  . ASN B 2 83  A -23.893 -0.686  9.862   1.00 45.49  ? 82  ASN F CB  1 
ATOM   2149 C CG  . ASN B 2 83  A -24.004 0.773   9.488   1.00 55.03  ? 82  ASN F CG  1 
ATOM   2150 O OD1 . ASN B 2 83  A -25.099 1.283   9.248   1.00 68.91  ? 82  ASN F OD1 1 
ATOM   2151 N ND2 . ASN B 2 83  A -22.869 1.460   9.444   1.00 66.27  ? 82  ASN F ND2 1 
ATOM   2152 N N   . SER B 2 84  B -25.192 -3.527  10.215  1.00 56.59  ? 82  SER F N   1 
ATOM   2153 C CA  . SER B 2 84  B -25.029 -4.966  10.430  1.00 50.11  ? 82  SER F CA  1 
ATOM   2154 C C   . SER B 2 84  B -25.712 -5.407  11.721  1.00 48.86  ? 82  SER F C   1 
ATOM   2155 O O   . SER B 2 84  B -25.125 -6.083  12.569  1.00 52.80  ? 82  SER F O   1 
ATOM   2156 C CB  . SER B 2 84  B -23.550 -5.357  10.435  1.00 50.00  ? 82  SER F CB  1 
ATOM   2157 O OG  . SER B 2 84  B -22.946 -5.099  9.179   1.00 69.99  ? 82  SER F OG  1 
ATOM   2158 N N   . LEU B 2 85  C -26.971 -5.008  11.867  1.00 52.13  ? 82  LEU F N   1 
ATOM   2159 C CA  . LEU B 2 85  C -27.713 -5.301  13.081  1.00 56.21  ? 82  LEU F CA  1 
ATOM   2160 C C   . LEU B 2 85  C -27.926 -6.802  13.243  1.00 57.38  ? 82  LEU F C   1 
ATOM   2161 O O   . LEU B 2 85  C -27.992 -7.556  12.269  1.00 62.55  ? 82  LEU F O   1 
ATOM   2162 C CB  . LEU B 2 85  C -29.055 -4.573  13.067  1.00 48.05  ? 82  LEU F CB  1 
ATOM   2163 C CG  . LEU B 2 85  C -29.031 -3.164  13.649  1.00 38.12  ? 82  LEU F CG  1 
ATOM   2164 C CD1 . LEU B 2 85  C -30.331 -2.459  13.333  1.00 53.57  ? 82  LEU F CD1 1 
ATOM   2165 C CD2 . LEU B 2 85  C -28.803 -3.230  15.152  1.00 42.07  ? 82  LEU F CD2 1 
ATOM   2166 N N   . ARG B 2 86  ? -28.020 -7.232  14.498  1.00 57.99  ? 83  ARG F N   1 
ATOM   2167 C CA  . ARG B 2 86  ? -28.230 -8.626  14.847  1.00 49.62  ? 83  ARG F CA  1 
ATOM   2168 C C   . ARG B 2 86  ? -29.491 -8.754  15.689  1.00 57.22  ? 83  ARG F C   1 
ATOM   2169 O O   . ARG B 2 86  ? -29.993 -7.773  16.246  1.00 63.81  ? 83  ARG F O   1 
ATOM   2170 C CB  . ARG B 2 86  ? -27.031 -9.197  15.614  1.00 56.07  ? 83  ARG F CB  1 
ATOM   2171 C CG  . ARG B 2 86  ? -25.703 -9.022  14.903  1.00 59.75  ? 83  ARG F CG  1 
ATOM   2172 C CD  . ARG B 2 86  ? -24.548 -9.386  15.816  1.00 61.71  ? 83  ARG F CD  1 
ATOM   2173 N NE  . ARG B 2 86  ? -23.264 -9.282  15.136  1.00 64.00  ? 83  ARG F NE  1 
ATOM   2174 C CZ  . ARG B 2 86  ? -22.088 -9.395  15.738  1.00 71.10  ? 83  ARG F CZ  1 
ATOM   2175 N NH1 . ARG B 2 86  ? -21.998 -9.616  17.039  1.00 62.13  ? 83  ARG F NH1 1 
ATOM   2176 N NH2 . ARG B 2 86  ? -20.976 -9.277  15.018  1.00 72.70  ? 83  ARG F NH2 1 
ATOM   2177 N N   . VAL B 2 87  ? -29.999 -9.985  15.780  1.00 59.61  ? 84  VAL F N   1 
ATOM   2178 C CA  . VAL B 2 87  ? -31.217 -10.228 16.546  1.00 59.33  ? 84  VAL F CA  1 
ATOM   2179 C C   . VAL B 2 87  ? -30.983 -9.931  18.023  1.00 50.14  ? 84  VAL F C   1 
ATOM   2180 O O   . VAL B 2 87  ? -31.874 -9.443  18.728  1.00 42.43  ? 84  VAL F O   1 
ATOM   2181 C CB  . VAL B 2 87  ? -31.705 -11.671 16.319  1.00 47.47  ? 84  VAL F CB  1 
ATOM   2182 C CG1 . VAL B 2 87  ? -33.103 -11.860 16.898  1.00 50.30  ? 84  VAL F CG1 1 
ATOM   2183 C CG2 . VAL B 2 87  ? -31.694 -11.993 14.838  1.00 49.05  ? 84  VAL F CG2 1 
ATOM   2184 N N   . GLU B 2 88  ? -29.777 -10.218 18.513  1.00 59.22  ? 85  GLU F N   1 
ATOM   2185 C CA  . GLU B 2 88  ? -29.456 -9.953  19.912  1.00 60.22  ? 85  GLU F CA  1 
ATOM   2186 C C   . GLU B 2 88  ? -29.349 -8.461  20.217  1.00 58.83  ? 85  GLU F C   1 
ATOM   2187 O O   . GLU B 2 88  ? -29.373 -8.077  21.393  1.00 55.06  ? 85  GLU F O   1 
ATOM   2188 C CB  . GLU B 2 88  ? -28.159 -10.668 20.289  1.00 59.89  ? 85  GLU F CB  1 
ATOM   2189 C CG  . GLU B 2 88  ? -27.207 -10.842 19.121  1.00 60.67  ? 85  GLU F CG  1 
ATOM   2190 C CD  . GLU B 2 88  ? -25.992 -11.663 19.488  1.00 88.82  ? 85  GLU F CD  1 
ATOM   2191 O OE1 . GLU B 2 88  ? -25.679 -11.754 20.696  1.00 84.32  ? 85  GLU F OE1 1 
ATOM   2192 O OE2 . GLU B 2 88  ? -25.352 -12.222 18.572  1.00 92.84  ? 85  GLU F OE2 1 
ATOM   2193 N N   . ASP B 2 89  ? -29.243 -7.612  19.193  1.00 51.31  ? 86  ASP F N   1 
ATOM   2194 C CA  . ASP B 2 89  ? -29.222 -6.169  19.407  1.00 40.82  ? 86  ASP F CA  1 
ATOM   2195 C C   . ASP B 2 89  ? -30.585 -5.608  19.792  1.00 49.81  ? 86  ASP F C   1 
ATOM   2196 O O   . ASP B 2 89  ? -30.671 -4.421  20.130  1.00 49.72  ? 86  ASP F O   1 
ATOM   2197 C CB  . ASP B 2 89  ? -28.709 -5.451  18.156  1.00 39.45  ? 86  ASP F CB  1 
ATOM   2198 C CG  . ASP B 2 89  ? -27.216 -5.629  17.951  1.00 49.36  ? 86  ASP F CG  1 
ATOM   2199 O OD1 . ASP B 2 89  ? -26.474 -5.663  18.957  1.00 61.81  ? 86  ASP F OD1 1 
ATOM   2200 O OD2 . ASP B 2 89  ? -26.781 -5.730  16.785  1.00 43.37  ? 86  ASP F OD2 1 
ATOM   2201 N N   . THR B 2 90  ? -31.643 -6.419  19.737  1.00 53.47  ? 87  THR F N   1 
ATOM   2202 C CA  . THR B 2 90  ? -32.987 -5.966  20.072  1.00 44.77  ? 87  THR F CA  1 
ATOM   2203 C C   . THR B 2 90  ? -33.049 -5.498  21.519  1.00 49.87  ? 87  THR F C   1 
ATOM   2204 O O   . THR B 2 90  ? -32.891 -6.299  22.446  1.00 61.06  ? 87  THR F O   1 
ATOM   2205 C CB  . THR B 2 90  ? -34.011 -7.079  19.833  1.00 35.36  ? 87  THR F CB  1 
ATOM   2206 O OG1 . THR B 2 90  ? -34.039 -7.412  18.440  1.00 51.21  ? 87  THR F OG1 1 
ATOM   2207 C CG2 . THR B 2 90  ? -35.404 -6.637  20.276  1.00 30.97  ? 87  THR F CG2 1 
ATOM   2208 N N   . ALA B 2 91  ? -33.275 -4.205  21.718  1.00 42.47  ? 88  ALA F N   1 
ATOM   2209 C CA  . ALA B 2 91  ? -33.297 -3.630  23.054  1.00 44.47  ? 88  ALA F CA  1 
ATOM   2210 C C   . ALA B 2 91  ? -33.931 -2.251  22.975  1.00 46.88  ? 88  ALA F C   1 
ATOM   2211 O O   . ALA B 2 91  ? -34.187 -1.723  21.890  1.00 50.76  ? 88  ALA F O   1 
ATOM   2212 C CB  . ALA B 2 91  ? -31.888 -3.553  23.652  1.00 50.77  ? 88  ALA F CB  1 
ATOM   2213 N N   . VAL B 2 92  ? -34.184 -1.675  24.145  1.00 39.75  ? 89  VAL F N   1 
ATOM   2214 C CA  . VAL B 2 92  ? -34.659 -0.301  24.249  1.00 44.01  ? 89  VAL F CA  1 
ATOM   2215 C C   . VAL B 2 92  ? -33.437 0.589   24.449  1.00 42.29  ? 89  VAL F C   1 
ATOM   2216 O O   . VAL B 2 92  ? -32.779 0.532   25.491  1.00 39.30  ? 89  VAL F O   1 
ATOM   2217 C CB  . VAL B 2 92  ? -35.669 -0.139  25.390  1.00 45.27  ? 89  VAL F CB  1 
ATOM   2218 C CG1 . VAL B 2 92  ? -36.140 1.308   25.490  1.00 35.18  ? 89  VAL F CG1 1 
ATOM   2219 C CG2 . VAL B 2 92  ? -36.847 -1.079  25.182  1.00 41.49  ? 89  VAL F CG2 1 
ATOM   2220 N N   . TYR B 2 93  ? -33.130 1.407   23.446  1.00 49.26  ? 90  TYR F N   1 
ATOM   2221 C CA  . TYR B 2 93  ? -31.939 2.247   23.452  1.00 43.25  ? 90  TYR F CA  1 
ATOM   2222 C C   . TYR B 2 93  ? -32.267 3.603   24.067  1.00 45.15  ? 90  TYR F C   1 
ATOM   2223 O O   . TYR B 2 93  ? -33.161 4.309   23.586  1.00 42.70  ? 90  TYR F O   1 
ATOM   2224 C CB  . TYR B 2 93  ? -31.398 2.410   22.032  1.00 36.54  ? 90  TYR F CB  1 
ATOM   2225 C CG  . TYR B 2 93  ? -30.786 1.144   21.471  1.00 42.81  ? 90  TYR F CG  1 
ATOM   2226 C CD1 . TYR B 2 93  ? -31.584 0.106   21.008  1.00 45.30  ? 90  TYR F CD1 1 
ATOM   2227 C CD2 . TYR B 2 93  ? -29.407 0.987   21.408  1.00 43.99  ? 90  TYR F CD2 1 
ATOM   2228 C CE1 . TYR B 2 93  ? -31.025 -1.054  20.500  1.00 48.43  ? 90  TYR F CE1 1 
ATOM   2229 C CE2 . TYR B 2 93  ? -28.841 -0.165  20.902  1.00 37.90  ? 90  TYR F CE2 1 
ATOM   2230 C CZ  . TYR B 2 93  ? -29.652 -1.183  20.450  1.00 40.71  ? 90  TYR F CZ  1 
ATOM   2231 O OH  . TYR B 2 93  ? -29.081 -2.330  19.948  1.00 48.87  ? 90  TYR F OH  1 
ATOM   2232 N N   . TYR B 2 94  ? -31.542 3.963   25.125  1.00 45.22  ? 91  TYR F N   1 
ATOM   2233 C CA  . TYR B 2 94  ? -31.729 5.228   25.820  1.00 39.17  ? 91  TYR F CA  1 
ATOM   2234 C C   . TYR B 2 94  ? -30.650 6.226   25.417  1.00 41.76  ? 91  TYR F C   1 
ATOM   2235 O O   . TYR B 2 94  ? -29.516 5.859   25.094  1.00 33.95  ? 91  TYR F O   1 
ATOM   2236 C CB  . TYR B 2 94  ? -31.709 5.042   27.341  1.00 45.86  ? 91  TYR F CB  1 
ATOM   2237 C CG  . TYR B 2 94  ? -32.861 4.232   27.904  1.00 50.46  ? 91  TYR F CG  1 
ATOM   2238 C CD1 . TYR B 2 94  ? -34.071 4.835   28.234  1.00 38.45  ? 91  TYR F CD1 1 
ATOM   2239 C CD2 . TYR B 2 94  ? -32.732 2.866   28.122  1.00 51.98  ? 91  TYR F CD2 1 
ATOM   2240 C CE1 . TYR B 2 94  ? -35.123 4.093   28.755  1.00 41.31  ? 91  TYR F CE1 1 
ATOM   2241 C CE2 . TYR B 2 94  ? -33.776 2.119   28.641  1.00 49.38  ? 91  TYR F CE2 1 
ATOM   2242 C CZ  . TYR B 2 94  ? -34.968 2.735   28.956  1.00 45.27  ? 91  TYR F CZ  1 
ATOM   2243 O OH  . TYR B 2 94  ? -36.001 1.984   29.473  1.00 50.95  ? 91  TYR F OH  1 
ATOM   2244 N N   . CYS B 2 95  ? -31.022 7.500   25.443  1.00 46.98  ? 92  CYS F N   1 
ATOM   2245 C CA  . CYS B 2 95  ? -30.122 8.610   25.167  1.00 38.16  ? 92  CYS F CA  1 
ATOM   2246 C C   . CYS B 2 95  ? -29.837 9.320   26.482  1.00 45.76  ? 92  CYS F C   1 
ATOM   2247 O O   . CYS B 2 95  ? -30.762 9.811   27.136  1.00 53.17  ? 92  CYS F O   1 
ATOM   2248 C CB  . CYS B 2 95  ? -30.747 9.568   24.158  1.00 40.91  ? 92  CYS F CB  1 
ATOM   2249 S SG  . CYS B 2 95  ? -29.750 10.998  23.770  1.00 79.56  ? 92  CYS F SG  1 
ATOM   2250 N N   . ALA B 2 96  ? -28.567 9.376   26.869  1.00 38.50  ? 93  ALA F N   1 
ATOM   2251 C CA  . ALA B 2 96  ? -28.201 9.881   28.183  1.00 35.03  ? 93  ALA F CA  1 
ATOM   2252 C C   . ALA B 2 96  ? -27.122 10.944  28.067  1.00 41.04  ? 93  ALA F C   1 
ATOM   2253 O O   . ALA B 2 96  ? -26.210 10.836  27.241  1.00 38.58  ? 93  ALA F O   1 
ATOM   2254 C CB  . ALA B 2 96  ? -27.717 8.751   29.096  1.00 38.08  ? 93  ALA F CB  1 
ATOM   2255 N N   . ARG B 2 97  ? -27.234 11.970  28.902  1.00 32.79  ? 94  ARG F N   1 
ATOM   2256 C CA  . ARG B 2 97  ? -26.203 12.988  29.022  1.00 34.66  ? 94  ARG F CA  1 
ATOM   2257 C C   . ARG B 2 97  ? -25.180 12.521  30.051  1.00 49.66  ? 94  ARG F C   1 
ATOM   2258 O O   . ARG B 2 97  ? -25.524 12.278  31.213  1.00 47.30  ? 94  ARG F O   1 
ATOM   2259 C CB  . ARG B 2 97  ? -26.819 14.326  29.422  1.00 35.78  ? 94  ARG F CB  1 
ATOM   2260 C CG  . ARG B 2 97  ? -25.824 15.439  29.667  1.00 40.83  ? 94  ARG F CG  1 
ATOM   2261 C CD  . ARG B 2 97  ? -26.560 16.756  29.793  1.00 49.55  ? 94  ARG F CD  1 
ATOM   2262 N NE  . ARG B 2 97  ? -25.684 17.867  30.141  1.00 52.66  ? 94  ARG F NE  1 
ATOM   2263 C CZ  . ARG B 2 97  ? -25.683 18.474  31.319  1.00 46.46  ? 94  ARG F CZ  1 
ATOM   2264 N NH1 . ARG B 2 97  ? -26.493 18.094  32.293  1.00 36.15  ? 94  ARG F NH1 1 
ATOM   2265 N NH2 . ARG B 2 97  ? -24.854 19.493  31.521  1.00 60.22  ? 94  ARG F NH2 1 
ATOM   2266 N N   . ASP B 2 98  ? -23.931 12.390  29.620  1.00 50.00  ? 95  ASP F N   1 
ATOM   2267 C CA  . ASP B 2 98  ? -22.870 11.813  30.433  1.00 44.26  ? 95  ASP F CA  1 
ATOM   2268 C C   . ASP B 2 98  ? -22.083 12.927  31.110  1.00 45.07  ? 95  ASP F C   1 
ATOM   2269 O O   . ASP B 2 98  ? -21.708 13.911  30.463  1.00 66.64  ? 95  ASP F O   1 
ATOM   2270 C CB  . ASP B 2 98  ? -21.950 10.954  29.563  1.00 43.77  ? 95  ASP F CB  1 
ATOM   2271 C CG  . ASP B 2 98  ? -21.144 9.954   30.367  1.00 64.91  ? 95  ASP F CG  1 
ATOM   2272 O OD1 . ASP B 2 98  ? -20.941 10.175  31.580  1.00 79.86  ? 95  ASP F OD1 1 
ATOM   2273 O OD2 . ASP B 2 98  ? -20.707 8.943   29.777  1.00 58.51  ? 95  ASP F OD2 1 
ATOM   2274 N N   . PHE B 2 99  ? -21.841 12.776  32.412  1.00 39.21  ? 96  PHE F N   1 
ATOM   2275 C CA  . PHE B 2 99  ? -21.045 13.736  33.178  1.00 39.70  ? 96  PHE F CA  1 
ATOM   2276 C C   . PHE B 2 99  ? -19.607 13.229  33.219  1.00 38.93  ? 96  PHE F C   1 
ATOM   2277 O O   . PHE B 2 99  ? -19.203 12.523  34.143  1.00 47.06  ? 96  PHE F O   1 
ATOM   2278 C CB  . PHE B 2 99  ? -21.609 13.938  34.580  1.00 39.19  ? 96  PHE F CB  1 
ATOM   2279 C CG  . PHE B 2 99  ? -20.869 14.976  35.377  1.00 47.74  ? 96  PHE F CG  1 
ATOM   2280 C CD1 . PHE B 2 99  ? -21.118 16.326  35.182  1.00 43.57  ? 96  PHE F CD1 1 
ATOM   2281 C CD2 . PHE B 2 99  ? -19.912 14.606  36.309  1.00 52.51  ? 96  PHE F CD2 1 
ATOM   2282 C CE1 . PHE B 2 99  ? -20.434 17.284  35.905  1.00 35.65  ? 96  PHE F CE1 1 
ATOM   2283 C CE2 . PHE B 2 99  ? -19.223 15.561  37.035  1.00 40.62  ? 96  PHE F CE2 1 
ATOM   2284 C CZ  . PHE B 2 99  ? -19.485 16.901  36.833  1.00 36.80  ? 96  PHE F CZ  1 
ATOM   2285 N N   . GLY B 2 100 ? -18.834 13.596  32.202  1.00 46.27  ? 97  GLY F N   1 
ATOM   2286 C CA  . GLY B 2 100 ? -17.418 13.263  32.170  1.00 41.69  ? 97  GLY F CA  1 
ATOM   2287 C C   . GLY B 2 100 ? -17.116 11.781  32.167  1.00 55.16  ? 97  GLY F C   1 
ATOM   2288 O O   . GLY B 2 100 ? -16.207 11.338  32.880  1.00 79.75  ? 97  GLY F O   1 
ATOM   2289 N N   . ASP B 2 101 ? -17.862 11.000  31.381  1.00 47.78  ? 98  ASP F N   1 
ATOM   2290 C CA  . ASP B 2 101 ? -17.642 9.559   31.254  1.00 46.62  ? 98  ASP F CA  1 
ATOM   2291 C C   . ASP B 2 101 ? -17.810 8.839   32.592  1.00 54.30  ? 98  ASP F C   1 
ATOM   2292 O O   . ASP B 2 101 ? -17.216 7.783   32.820  1.00 68.02  ? 98  ASP F O   1 
ATOM   2293 C CB  . ASP B 2 101 ? -16.260 9.267   30.655  1.00 45.30  ? 98  ASP F CB  1 
ATOM   2294 C CG  . ASP B 2 101 ? -16.149 7.868   30.083  1.00 60.06  ? 98  ASP F CG  1 
ATOM   2295 O OD1 . ASP B 2 101 ? -16.652 7.643   28.962  1.00 61.11  ? 98  ASP F OD1 1 
ATOM   2296 O OD2 . ASP B 2 101 ? -15.559 6.995   30.756  1.00 71.58  ? 98  ASP F OD2 1 
ATOM   2297 N N   . PHE B 2 102 ? -18.617 9.399   33.495  1.00 47.03  ? 99  PHE F N   1 
ATOM   2298 C CA  . PHE B 2 102 ? -18.815 8.822   34.820  1.00 54.74  ? 99  PHE F CA  1 
ATOM   2299 C C   . PHE B 2 102 ? -20.242 8.336   35.037  1.00 50.20  ? 99  PHE F C   1 
ATOM   2300 O O   . PHE B 2 102 ? -20.460 7.149   35.291  1.00 60.33  ? 99  PHE F O   1 
ATOM   2301 C CB  . PHE B 2 102 ? -18.433 9.843   35.904  1.00 57.57  ? 99  PHE F CB  1 
ATOM   2302 C CG  . PHE B 2 102 ? -16.977 10.215  35.904  1.00 47.44  ? 99  PHE F CG  1 
ATOM   2303 C CD1 . PHE B 2 102 ? -16.027 9.342   35.401  1.00 49.57  ? 99  PHE F CD1 1 
ATOM   2304 C CD2 . PHE B 2 102 ? -16.559 11.438  36.404  1.00 43.41  ? 99  PHE F CD2 1 
ATOM   2305 C CE1 . PHE B 2 102 ? -14.686 9.681   35.396  1.00 58.91  ? 99  PHE F CE1 1 
ATOM   2306 C CE2 . PHE B 2 102 ? -15.219 11.783  36.401  1.00 60.02  ? 99  PHE F CE2 1 
ATOM   2307 C CZ  . PHE B 2 102 ? -14.282 10.902  35.896  1.00 57.55  ? 99  PHE F CZ  1 
ATOM   2308 N N   . TYR B 2 103 ? -21.234 9.214   34.925  1.00 49.97  ? 100 TYR F N   1 
ATOM   2309 C CA  . TYR B 2 103 ? -22.603 8.809   35.202  1.00 44.98  ? 100 TYR F CA  1 
ATOM   2310 C C   . TYR B 2 103 ? -23.557 9.640   34.361  1.00 41.10  ? 100 TYR F C   1 
ATOM   2311 O O   . TYR B 2 103 ? -23.196 10.689  33.823  1.00 47.88  ? 100 TYR F O   1 
ATOM   2312 C CB  . TYR B 2 103 ? -22.940 8.925   36.695  1.00 39.79  ? 100 TYR F CB  1 
ATOM   2313 C CG  . TYR B 2 103 ? -22.634 10.266  37.318  1.00 43.20  ? 100 TYR F CG  1 
ATOM   2314 C CD1 . TYR B 2 103 ? -21.390 10.525  37.878  1.00 49.61  ? 100 TYR F CD1 1 
ATOM   2315 C CD2 . TYR B 2 103 ? -23.595 11.268  37.365  1.00 49.44  ? 100 TYR F CD2 1 
ATOM   2316 C CE1 . TYR B 2 103 ? -21.106 11.749  38.458  1.00 43.82  ? 100 TYR F CE1 1 
ATOM   2317 C CE2 . TYR B 2 103 ? -23.321 12.495  37.941  1.00 47.40  ? 100 TYR F CE2 1 
ATOM   2318 C CZ  . TYR B 2 103 ? -22.074 12.729  38.486  1.00 42.98  ? 100 TYR F CZ  1 
ATOM   2319 O OH  . TYR B 2 103 ? -21.792 13.945  39.063  1.00 48.52  ? 100 TYR F OH  1 
ATOM   2320 N N   . PHE B 2 104 A -24.781 9.149   34.251  1.00 44.98  ? 100 PHE F N   1 
ATOM   2321 C CA  . PHE B 2 104 A -25.784 9.708   33.352  1.00 48.11  ? 100 PHE F CA  1 
ATOM   2322 C C   . PHE B 2 104 A -26.805 10.467  34.197  1.00 45.76  ? 100 PHE F C   1 
ATOM   2323 O O   . PHE B 2 104 A -27.690 9.863   34.810  1.00 45.05  ? 100 PHE F O   1 
ATOM   2324 C CB  . PHE B 2 104 A -26.422 8.593   32.527  1.00 37.20  ? 100 PHE F CB  1 
ATOM   2325 C CG  . PHE B 2 104 A -25.456 7.497   32.147  1.00 38.39  ? 100 PHE F CG  1 
ATOM   2326 C CD1 . PHE B 2 104 A -24.646 7.617   31.026  1.00 53.89  ? 100 PHE F CD1 1 
ATOM   2327 C CD2 . PHE B 2 104 A -25.350 6.352   32.920  1.00 47.90  ? 100 PHE F CD2 1 
ATOM   2328 C CE1 . PHE B 2 104 A -23.752 6.610   30.683  1.00 41.46  ? 100 PHE F CE1 1 
ATOM   2329 C CE2 . PHE B 2 104 A -24.458 5.345   32.582  1.00 46.97  ? 100 PHE F CE2 1 
ATOM   2330 C CZ  . PHE B 2 104 A -23.661 5.473   31.463  1.00 34.19  ? 100 PHE F CZ  1 
ATOM   2331 N N   . ASP B 2 105 ? -26.672 11.796  34.232  1.00 40.79  ? 101 ASP F N   1 
ATOM   2332 C CA  . ASP B 2 105 ? -27.544 12.618  35.063  1.00 42.28  ? 101 ASP F CA  1 
ATOM   2333 C C   . ASP B 2 105 ? -28.884 12.929  34.406  1.00 39.77  ? 101 ASP F C   1 
ATOM   2334 O O   . ASP B 2 105 ? -29.826 13.302  35.112  1.00 43.15  ? 101 ASP F O   1 
ATOM   2335 C CB  . ASP B 2 105 ? -26.836 13.924  35.444  1.00 60.48  ? 101 ASP F CB  1 
ATOM   2336 C CG  . ASP B 2 105 ? -26.240 14.646  34.244  1.00 65.82  ? 101 ASP F CG  1 
ATOM   2337 O OD1 . ASP B 2 105 ? -26.399 14.157  33.107  1.00 58.59  ? 101 ASP F OD1 1 
ATOM   2338 O OD2 . ASP B 2 105 ? -25.607 15.706  34.442  1.00 59.91  ? 101 ASP F OD2 1 
ATOM   2339 N N   . TYR B 2 106 ? -28.997 12.786  33.085  1.00 38.12  ? 102 TYR F N   1 
ATOM   2340 C CA  . TYR B 2 106 ? -30.251 13.016  32.379  1.00 41.32  ? 102 TYR F CA  1 
ATOM   2341 C C   . TYR B 2 106 ? -30.438 11.951  31.310  1.00 32.78  ? 102 TYR F C   1 
ATOM   2342 O O   . TYR B 2 106 ? -29.491 11.611  30.594  1.00 29.96  ? 102 TYR F O   1 
ATOM   2343 C CB  . TYR B 2 106 ? -30.295 14.407  31.734  1.00 45.59  ? 102 TYR F CB  1 
ATOM   2344 C CG  . TYR B 2 106 ? -30.354 15.545  32.725  1.00 50.22  ? 102 TYR F CG  1 
ATOM   2345 C CD1 . TYR B 2 106 ? -31.567 15.969  33.252  1.00 47.55  ? 102 TYR F CD1 1 
ATOM   2346 C CD2 . TYR B 2 106 ? -29.199 16.201  33.128  1.00 47.00  ? 102 TYR F CD2 1 
ATOM   2347 C CE1 . TYR B 2 106 ? -31.627 17.013  34.158  1.00 42.89  ? 102 TYR F CE1 1 
ATOM   2348 C CE2 . TYR B 2 106 ? -29.249 17.245  34.033  1.00 52.51  ? 102 TYR F CE2 1 
ATOM   2349 C CZ  . TYR B 2 106 ? -30.466 17.647  34.545  1.00 49.35  ? 102 TYR F CZ  1 
ATOM   2350 O OH  . TYR B 2 106 ? -30.521 18.686  35.447  1.00 43.22  ? 102 TYR F OH  1 
ATOM   2351 N N   . TRP B 2 107 ? -31.669 11.448  31.190  1.00 29.79  ? 103 TRP F N   1 
ATOM   2352 C CA  . TRP B 2 107 ? -31.992 10.344  30.295  1.00 39.43  ? 103 TRP F CA  1 
ATOM   2353 C C   . TRP B 2 107 ? -33.146 10.722  29.377  1.00 32.05  ? 103 TRP F C   1 
ATOM   2354 O O   . TRP B 2 107 ? -34.063 11.450  29.771  1.00 38.61  ? 103 TRP F O   1 
ATOM   2355 C CB  . TRP B 2 107 ? -32.374 9.075   31.078  1.00 42.43  ? 103 TRP F CB  1 
ATOM   2356 C CG  . TRP B 2 107 ? -31.262 8.476   31.879  1.00 28.75  ? 103 TRP F CG  1 
ATOM   2357 C CD1 . TRP B 2 107 ? -30.628 9.036   32.947  1.00 36.27  ? 103 TRP F CD1 1 
ATOM   2358 C CD2 . TRP B 2 107 ? -30.669 7.184   31.692  1.00 41.50  ? 103 TRP F CD2 1 
ATOM   2359 N NE1 . TRP B 2 107 ? -29.666 8.181   33.429  1.00 45.40  ? 103 TRP F NE1 1 
ATOM   2360 C CE2 . TRP B 2 107 ? -29.673 7.036   32.677  1.00 43.58  ? 103 TRP F CE2 1 
ATOM   2361 C CE3 . TRP B 2 107 ? -30.881 6.141   30.784  1.00 48.51  ? 103 TRP F CE3 1 
ATOM   2362 C CZ2 . TRP B 2 107 ? -28.890 5.889   32.780  1.00 41.24  ? 103 TRP F CZ2 1 
ATOM   2363 C CZ3 . TRP B 2 107 ? -30.102 5.002   30.888  1.00 42.72  ? 103 TRP F CZ3 1 
ATOM   2364 C CH2 . TRP B 2 107 ? -29.119 4.886   31.879  1.00 48.15  ? 103 TRP F CH2 1 
ATOM   2365 N N   . GLY B 2 108 ? -33.099 10.205  28.145  1.00 29.27  ? 104 GLY F N   1 
ATOM   2366 C CA  . GLY B 2 108 ? -34.222 10.336  27.241  1.00 40.59  ? 104 GLY F CA  1 
ATOM   2367 C C   . GLY B 2 108 ? -35.262 9.255   27.471  1.00 42.40  ? 104 GLY F C   1 
ATOM   2368 O O   . GLY B 2 108 ? -35.010 8.252   28.136  1.00 49.47  ? 104 GLY F O   1 
ATOM   2369 N N   . GLN B 2 109 ? -36.449 9.464   26.890  1.00 37.28  ? 105 GLN F N   1 
ATOM   2370 C CA  . GLN B 2 109 ? -37.557 8.537   27.111  1.00 38.60  ? 105 GLN F CA  1 
ATOM   2371 C C   . GLN B 2 109 ? -37.277 7.142   26.557  1.00 48.09  ? 105 GLN F C   1 
ATOM   2372 O O   . GLN B 2 109 ? -37.897 6.173   27.010  1.00 36.41  ? 105 GLN F O   1 
ATOM   2373 C CB  . GLN B 2 109 ? -38.849 9.095   26.503  1.00 46.94  ? 105 GLN F CB  1 
ATOM   2374 C CG  . GLN B 2 109 ? -39.142 8.658   25.066  1.00 49.16  ? 105 GLN F CG  1 
ATOM   2375 C CD  . GLN B 2 109 ? -38.660 9.654   24.025  1.00 53.79  ? 105 GLN F CD  1 
ATOM   2376 O OE1 . GLN B 2 109 ? -38.472 10.835  24.317  1.00 68.90  ? 105 GLN F OE1 1 
ATOM   2377 N NE2 . GLN B 2 109 ? -38.460 9.179   22.800  1.00 46.87  ? 105 GLN F NE2 1 
ATOM   2378 N N   . GLY B 2 110 ? -36.363 7.014   25.606  1.00 48.68  ? 106 GLY F N   1 
ATOM   2379 C CA  . GLY B 2 110 ? -36.010 5.710   25.062  1.00 44.59  ? 106 GLY F CA  1 
ATOM   2380 C C   . GLY B 2 110 ? -36.828 5.345   23.840  1.00 53.24  ? 106 GLY F C   1 
ATOM   2381 O O   . GLY B 2 110 ? -37.995 5.711   23.697  1.00 48.91  ? 106 GLY F O   1 
ATOM   2382 N N   . THR B 2 111 ? -36.195 4.601   22.936  1.00 45.59  ? 107 THR F N   1 
ATOM   2383 C CA  . THR B 2 111 ? -36.851 4.109   21.735  1.00 41.37  ? 107 THR F CA  1 
ATOM   2384 C C   . THR B 2 111 ? -36.527 2.632   21.558  1.00 51.48  ? 107 THR F C   1 
ATOM   2385 O O   . THR B 2 111 ? -35.449 2.166   21.940  1.00 47.93  ? 107 THR F O   1 
ATOM   2386 C CB  . THR B 2 111 ? -36.433 4.915   20.490  1.00 40.02  ? 107 THR F CB  1 
ATOM   2387 O OG1 . THR B 2 111 ? -37.168 4.455   19.349  1.00 57.77  ? 107 THR F OG1 1 
ATOM   2388 C CG2 . THR B 2 111 ? -34.942 4.774   20.223  1.00 42.73  ? 107 THR F CG2 1 
ATOM   2389 N N   . LEU B 2 112 ? -37.476 1.895   20.986  1.00 52.79  ? 108 LEU F N   1 
ATOM   2390 C CA  . LEU B 2 112 ? -37.393 0.442   20.898  1.00 48.05  ? 108 LEU F CA  1 
ATOM   2391 C C   . LEU B 2 112 ? -36.935 0.020   19.510  1.00 44.84  ? 108 LEU F C   1 
ATOM   2392 O O   . LEU B 2 112 ? -37.555 0.385   18.507  1.00 49.32  ? 108 LEU F O   1 
ATOM   2393 C CB  . LEU B 2 112 ? -38.741 -0.204  21.220  1.00 38.53  ? 108 LEU F CB  1 
ATOM   2394 C CG  . LEU B 2 112 ? -38.828 -1.722  21.036  1.00 45.61  ? 108 LEU F CG  1 
ATOM   2395 C CD1 . LEU B 2 112 ? -37.746 -2.438  21.832  1.00 36.96  ? 108 LEU F CD1 1 
ATOM   2396 C CD2 . LEU B 2 112 ? -40.206 -2.221  21.437  1.00 41.74  ? 108 LEU F CD2 1 
ATOM   2397 N N   . VAL B 2 113 ? -35.861 -0.760  19.462  1.00 45.80  ? 109 VAL F N   1 
ATOM   2398 C CA  . VAL B 2 113 ? -35.330 -1.310  18.221  1.00 42.43  ? 109 VAL F CA  1 
ATOM   2399 C C   . VAL B 2 113 ? -35.564 -2.810  18.242  1.00 53.44  ? 109 VAL F C   1 
ATOM   2400 O O   . VAL B 2 113 ? -35.084 -3.510  19.143  1.00 58.80  ? 109 VAL F O   1 
ATOM   2401 C CB  . VAL B 2 113 ? -33.840 -0.987  18.047  1.00 45.68  ? 109 VAL F CB  1 
ATOM   2402 C CG1 . VAL B 2 113 ? -33.220 -1.901  16.998  1.00 35.49  ? 109 VAL F CG1 1 
ATOM   2403 C CG2 . VAL B 2 113 ? -33.663 0.475   17.667  1.00 49.95  ? 109 VAL F CG2 1 
ATOM   2404 N N   . THR B 2 114 ? -36.302 -3.303  17.253  1.00 51.88  ? 110 THR F N   1 
ATOM   2405 C CA  . THR B 2 114 ? -36.619 -4.719  17.134  1.00 43.01  ? 110 THR F CA  1 
ATOM   2406 C C   . THR B 2 114 ? -35.975 -5.247  15.863  1.00 40.39  ? 110 THR F C   1 
ATOM   2407 O O   . THR B 2 114 ? -36.248 -4.740  14.771  1.00 51.25  ? 110 THR F O   1 
ATOM   2408 C CB  . THR B 2 114 ? -38.132 -4.940  17.100  1.00 51.32  ? 110 THR F CB  1 
ATOM   2409 O OG1 . THR B 2 114 ? -38.758 -4.120  18.094  1.00 43.58  ? 110 THR F OG1 1 
ATOM   2410 C CG2 . THR B 2 114 ? -38.458 -6.398  17.373  1.00 51.74  ? 110 THR F CG2 1 
ATOM   2411 N N   . VAL B 2 115 ? -35.124 -6.258  16.003  1.00 38.50  ? 111 VAL F N   1 
ATOM   2412 C CA  . VAL B 2 115 ? -34.435 -6.862  14.870  1.00 46.06  ? 111 VAL F CA  1 
ATOM   2413 C C   . VAL B 2 115 ? -34.984 -8.266  14.682  1.00 59.56  ? 111 VAL F C   1 
ATOM   2414 O O   . VAL B 2 115 ? -34.826 -9.128  15.555  1.00 58.54  ? 111 VAL F O   1 
ATOM   2415 C CB  . VAL B 2 115 ? -32.913 -6.888  15.067  1.00 50.58  ? 111 VAL F CB  1 
ATOM   2416 C CG1 . VAL B 2 115 ? -32.244 -7.511  13.853  1.00 52.95  ? 111 VAL F CG1 1 
ATOM   2417 C CG2 . VAL B 2 115 ? -32.386 -5.485  15.298  1.00 44.44  ? 111 VAL F CG2 1 
ATOM   2418 N N   . SER B 2 116 ? -35.625 -8.493  13.541  1.00 68.31  ? 112 SER F N   1 
ATOM   2419 C CA  . SER B 2 116 ? -36.222 -9.784  13.247  1.00 60.45  ? 112 SER F CA  1 
ATOM   2420 C C   . SER B 2 116 ? -36.466 -9.877  11.754  1.00 59.28  ? 112 SER F C   1 
ATOM   2421 O O   . SER B 2 116 ? -36.687 -8.865  11.082  1.00 53.85  ? 112 SER F O   1 
ATOM   2422 C CB  . SER B 2 116 ? -37.537 -9.985  14.007  1.00 53.47  ? 112 SER F CB  1 
ATOM   2423 O OG  . SER B 2 116 ? -38.179 -11.178 13.593  1.00 65.51  ? 112 SER F OG  1 
ATOM   2424 N N   . SER B 2 117 ? -36.429 -11.103 11.246  1.00 66.62  ? 113 SER F N   1 
ATOM   2425 C CA  . SER B 2 117 ? -36.821 -11.361 9.870   1.00 65.51  ? 113 SER F CA  1 
ATOM   2426 C C   . SER B 2 117 ? -38.335 -11.427 9.702   1.00 62.69  ? 113 SER F C   1 
ATOM   2427 O O   . SER B 2 117 ? -38.811 -11.551 8.569   1.00 63.73  ? 113 SER F O   1 
ATOM   2428 C CB  . SER B 2 117 ? -36.168 -12.654 9.376   1.00 48.63  ? 113 SER F CB  1 
ATOM   2429 O OG  . SER B 2 117 ? -36.336 -13.696 10.320  1.00 69.75  ? 113 SER F OG  1 
ATOM   2430 N N   . ALA B 2 118 ? -39.094 -11.342 10.794  1.00 53.14  ? 114 ALA F N   1 
ATOM   2431 C CA  . ALA B 2 118 ? -40.547 -11.303 10.721  1.00 52.46  ? 114 ALA F CA  1 
ATOM   2432 C C   . ALA B 2 118 ? -41.020 -9.970  10.142  1.00 59.25  ? 114 ALA F C   1 
ATOM   2433 O O   . ALA B 2 118 ? -40.306 -8.963  10.161  1.00 59.29  ? 114 ALA F O   1 
ATOM   2434 C CB  . ALA B 2 118 ? -41.160 -11.524 12.104  1.00 43.61  ? 114 ALA F CB  1 
ATOM   2435 N N   . SER B 2 119 ? -42.249 -9.973  9.631   1.00 54.73  ? 115 SER F N   1 
ATOM   2436 C CA  . SER B 2 119 ? -42.813 -8.841  8.909   1.00 53.78  ? 115 SER F CA  1 
ATOM   2437 C C   . SER B 2 119 ? -43.832 -8.110  9.771   1.00 50.15  ? 115 SER F C   1 
ATOM   2438 O O   . SER B 2 119 ? -44.355 -8.650  10.749  1.00 54.24  ? 115 SER F O   1 
ATOM   2439 C CB  . SER B 2 119 ? -43.476 -9.296  7.603   1.00 55.02  ? 115 SER F CB  1 
ATOM   2440 O OG  . SER B 2 119 ? -42.740 -10.337 6.985   1.00 76.27  ? 115 SER F OG  1 
ATOM   2441 N N   . THR B 2 120 ? -44.114 -6.866  9.392   1.00 41.39  ? 116 THR F N   1 
ATOM   2442 C CA  . THR B 2 120 ? -45.065 -6.058  10.142  1.00 42.37  ? 116 THR F CA  1 
ATOM   2443 C C   . THR B 2 120 ? -46.478 -6.579  9.915   1.00 38.84  ? 116 THR F C   1 
ATOM   2444 O O   . THR B 2 120 ? -46.886 -6.826  8.777   1.00 47.62  ? 116 THR F O   1 
ATOM   2445 C CB  . THR B 2 120 ? -44.955 -4.589  9.733   1.00 34.92  ? 116 THR F CB  1 
ATOM   2446 O OG1 . THR B 2 120 ? -43.605 -4.145  9.924   1.00 43.41  ? 116 THR F OG1 1 
ATOM   2447 C CG2 . THR B 2 120 ? -45.882 -3.728  10.572  1.00 30.24  ? 116 THR F CG2 1 
ATOM   2448 N N   . LYS B 2 121 ? -47.217 -6.767  11.004  1.00 33.88  ? 117 LYS F N   1 
ATOM   2449 C CA  . LYS B 2 121 ? -48.581 -7.267  10.953  1.00 35.91  ? 117 LYS F CA  1 
ATOM   2450 C C   . LYS B 2 121 ? -49.482 -6.313  11.719  1.00 43.00  ? 117 LYS F C   1 
ATOM   2451 O O   . LYS B 2 121 ? -49.110 -5.817  12.786  1.00 39.45  ? 117 LYS F O   1 
ATOM   2452 C CB  . LYS B 2 121 ? -48.677 -8.680  11.544  1.00 44.25  ? 117 LYS F CB  1 
ATOM   2453 C CG  . LYS B 2 121 ? -50.016 -9.372  11.330  1.00 47.71  ? 117 LYS F CG  1 
ATOM   2454 C CD  . LYS B 2 121 ? -50.001 -10.196 10.049  1.00 65.63  ? 117 LYS F CD  1 
ATOM   2455 C CE  . LYS B 2 121 ? -51.317 -10.935 9.833   1.00 58.84  ? 117 LYS F CE  1 
ATOM   2456 N NZ  . LYS B 2 121 ? -51.324 -11.701 8.549   1.00 44.10  ? 117 LYS F NZ  1 
ATOM   2457 N N   . GLY B 2 122 ? -50.659 -6.045  11.165  1.00 49.47  ? 118 GLY F N   1 
ATOM   2458 C CA  . GLY B 2 122 ? -51.621 -5.187  11.814  1.00 39.57  ? 118 GLY F CA  1 
ATOM   2459 C C   . GLY B 2 122 ? -52.421 -5.927  12.866  1.00 59.81  ? 118 GLY F C   1 
ATOM   2460 O O   . GLY B 2 122 ? -52.696 -7.125  12.744  1.00 68.13  ? 118 GLY F O   1 
ATOM   2461 N N   . PRO B 2 123 ? -52.809 -5.223  13.926  1.00 46.55  ? 119 PRO F N   1 
ATOM   2462 C CA  . PRO B 2 123 ? -53.582 -5.856  14.998  1.00 47.94  ? 119 PRO F CA  1 
ATOM   2463 C C   . PRO B 2 123 ? -55.063 -5.961  14.672  1.00 53.67  ? 119 PRO F C   1 
ATOM   2464 O O   . PRO B 2 123 ? -55.646 -5.107  14.000  1.00 53.10  ? 119 PRO F O   1 
ATOM   2465 C CB  . PRO B 2 123 ? -53.358 -4.914  16.185  1.00 43.01  ? 119 PRO F CB  1 
ATOM   2466 C CG  . PRO B 2 123 ? -53.195 -3.577  15.545  1.00 56.44  ? 119 PRO F CG  1 
ATOM   2467 C CD  . PRO B 2 123 ? -52.480 -3.821  14.236  1.00 51.03  ? 119 PRO F CD  1 
ATOM   2468 N N   . SER B 2 124 ? -55.675 -7.025  15.184  1.00 41.45  ? 120 SER F N   1 
ATOM   2469 C CA  . SER B 2 124 ? -57.118 -7.214  15.126  1.00 41.29  ? 120 SER F CA  1 
ATOM   2470 C C   . SER B 2 124 ? -57.692 -6.974  16.515  1.00 44.08  ? 120 SER F C   1 
ATOM   2471 O O   . SER B 2 124 ? -57.185 -7.518  17.501  1.00 50.48  ? 120 SER F O   1 
ATOM   2472 C CB  . SER B 2 124 ? -57.472 -8.619  14.634  1.00 44.20  ? 120 SER F CB  1 
ATOM   2473 O OG  . SER B 2 124 ? -56.922 -8.866  13.352  1.00 53.30  ? 120 SER F OG  1 
ATOM   2474 N N   . VAL B 2 125 ? -58.736 -6.154  16.593  1.00 46.90  ? 121 VAL F N   1 
ATOM   2475 C CA  . VAL B 2 125 ? -59.335 -5.753  17.861  1.00 47.48  ? 121 VAL F CA  1 
ATOM   2476 C C   . VAL B 2 125 ? -60.696 -6.422  17.989  1.00 49.09  ? 121 VAL F C   1 
ATOM   2477 O O   . VAL B 2 125 ? -61.549 -6.284  17.104  1.00 62.24  ? 121 VAL F O   1 
ATOM   2478 C CB  . VAL B 2 125 ? -59.460 -4.224  17.971  1.00 53.34  ? 121 VAL F CB  1 
ATOM   2479 C CG1 . VAL B 2 125 ? -59.797 -3.825  19.398  1.00 60.30  ? 121 VAL F CG1 1 
ATOM   2480 C CG2 . VAL B 2 125 ? -58.175 -3.549  17.512  1.00 48.66  ? 121 VAL F CG2 1 
ATOM   2481 N N   . PHE B 2 126 ? -60.900 -7.143  19.094  1.00 50.54  ? 122 PHE F N   1 
ATOM   2482 C CA  . PHE B 2 126 ? -62.139 -7.856  19.348  1.00 43.52  ? 122 PHE F CA  1 
ATOM   2483 C C   . PHE B 2 126 ? -62.755 -7.399  20.663  1.00 40.74  ? 122 PHE F C   1 
ATOM   2484 O O   . PHE B 2 126 ? -62.031 -7.112  21.622  1.00 50.08  ? 122 PHE F O   1 
ATOM   2485 C CB  . PHE B 2 126 ? -61.910 -9.376  19.400  1.00 45.06  ? 122 PHE F CB  1 
ATOM   2486 C CG  . PHE B 2 126 ? -61.200 -9.925  18.196  1.00 49.68  ? 122 PHE F CG  1 
ATOM   2487 C CD1 . PHE B 2 126 ? -61.851 -10.030 16.977  1.00 43.31  ? 122 PHE F CD1 1 
ATOM   2488 C CD2 . PHE B 2 126 ? -59.883 -10.344 18.285  1.00 48.24  ? 122 PHE F CD2 1 
ATOM   2489 C CE1 . PHE B 2 126 ? -61.198 -10.536 15.869  1.00 47.81  ? 122 PHE F CE1 1 
ATOM   2490 C CE2 . PHE B 2 126 ? -59.226 -10.851 17.181  1.00 41.23  ? 122 PHE F CE2 1 
ATOM   2491 C CZ  . PHE B 2 126 ? -59.885 -10.948 15.972  1.00 44.29  ? 122 PHE F CZ  1 
ATOM   2492 N N   . PRO B 2 127 ? -64.080 -7.328  20.743  1.00 47.97  ? 123 PRO F N   1 
ATOM   2493 C CA  . PRO B 2 127 ? -64.718 -6.829  21.965  1.00 47.17  ? 123 PRO F CA  1 
ATOM   2494 C C   . PRO B 2 127 ? -64.803 -7.899  23.042  1.00 50.81  ? 123 PRO F C   1 
ATOM   2495 O O   . PRO B 2 127 ? -65.038 -9.078  22.764  1.00 46.52  ? 123 PRO F O   1 
ATOM   2496 C CB  . PRO B 2 127 ? -66.113 -6.416  21.482  1.00 48.60  ? 123 PRO F CB  1 
ATOM   2497 C CG  . PRO B 2 127 ? -66.386 -7.342  20.340  1.00 51.00  ? 123 PRO F CG  1 
ATOM   2498 C CD  . PRO B 2 127 ? -65.058 -7.606  19.676  1.00 49.86  ? 123 PRO F CD  1 
ATOM   2499 N N   . LEU B 2 128 ? -64.604 -7.471  24.287  1.00 48.97  ? 124 LEU F N   1 
ATOM   2500 C CA  . LEU B 2 128 ? -64.862 -8.302  25.462  1.00 42.85  ? 124 LEU F CA  1 
ATOM   2501 C C   . LEU B 2 128 ? -66.170 -7.796  26.062  1.00 54.27  ? 124 LEU F C   1 
ATOM   2502 O O   . LEU B 2 128 ? -66.183 -6.915  26.921  1.00 68.80  ? 124 LEU F O   1 
ATOM   2503 C CB  . LEU B 2 128 ? -63.707 -8.238  26.455  1.00 44.28  ? 124 LEU F CB  1 
ATOM   2504 C CG  . LEU B 2 128 ? -62.347 -8.723  25.946  1.00 44.98  ? 124 LEU F CG  1 
ATOM   2505 C CD1 . LEU B 2 128 ? -61.284 -8.574  27.021  1.00 41.13  ? 124 LEU F CD1 1 
ATOM   2506 C CD2 . LEU B 2 128 ? -62.439 -10.163 25.478  1.00 36.36  ? 124 LEU F CD2 1 
ATOM   2507 N N   . ALA B 2 129 ? -67.276 -8.361  25.593  1.00 52.63  ? 125 ALA F N   1 
ATOM   2508 C CA  . ALA B 2 129 ? -68.594 -7.834  25.927  1.00 54.87  ? 125 ALA F CA  1 
ATOM   2509 C C   . ALA B 2 129 ? -68.910 -8.049  27.402  1.00 60.35  ? 125 ALA F C   1 
ATOM   2510 O O   . ALA B 2 129 ? -68.703 -9.152  27.922  1.00 66.79  ? 125 ALA F O   1 
ATOM   2511 C CB  . ALA B 2 129 ? -69.662 -8.499  25.062  1.00 70.34  ? 125 ALA F CB  1 
ATOM   2512 N N   . PRO B 2 130 ? -69.405 -7.032  28.107  1.00 65.76  ? 126 PRO F N   1 
ATOM   2513 C CA  . PRO B 2 130 ? -69.899 -7.256  29.469  1.00 61.73  ? 126 PRO F CA  1 
ATOM   2514 C C   . PRO B 2 130 ? -71.098 -8.189  29.455  1.00 70.05  ? 126 PRO F C   1 
ATOM   2515 O O   . PRO B 2 130 ? -71.902 -8.193  28.521  1.00 79.95  ? 126 PRO F O   1 
ATOM   2516 C CB  . PRO B 2 130 ? -70.290 -5.852  29.948  1.00 70.88  ? 126 PRO F CB  1 
ATOM   2517 C CG  . PRO B 2 130 ? -69.613 -4.910  29.009  1.00 65.98  ? 126 PRO F CG  1 
ATOM   2518 C CD  . PRO B 2 130 ? -69.513 -5.622  27.701  1.00 69.57  ? 126 PRO F CD  1 
ATOM   2519 N N   . SER B 2 131 ? -71.213 -8.989  30.508  1.00 72.36  ? 127 SER F N   1 
ATOM   2520 C CA  . SER B 2 131 ? -72.301 -9.948  30.623  1.00 65.83  ? 127 SER F CA  1 
ATOM   2521 C C   . SER B 2 131 ? -72.476 -10.292 32.093  1.00 75.36  ? 127 SER F C   1 
ATOM   2522 O O   . SER B 2 131 ? -71.737 -9.811  32.955  1.00 85.92  ? 127 SER F O   1 
ATOM   2523 C CB  . SER B 2 131 ? -72.031 -11.200 29.785  1.00 62.39  ? 127 SER F CB  1 
ATOM   2524 O OG  . SER B 2 131 ? -73.088 -12.132 29.921  1.00 82.95  ? 127 SER F OG  1 
ATOM   2525 N N   . SER B 2 132 ? -73.471 -11.137 32.375  1.00 75.98  ? 128 SER F N   1 
ATOM   2526 C CA  . SER B 2 132 ? -73.669 -11.601 33.743  1.00 81.23  ? 128 SER F CA  1 
ATOM   2527 C C   . SER B 2 132 ? -72.426 -12.299 34.277  1.00 87.99  ? 128 SER F C   1 
ATOM   2528 O O   . SER B 2 132 ? -72.149 -12.239 35.481  1.00 86.13  ? 128 SER F O   1 
ATOM   2529 C CB  . SER B 2 132 ? -74.879 -12.532 33.811  1.00 86.62  ? 128 SER F CB  1 
ATOM   2530 O OG  . SER B 2 132 ? -74.718 -13.636 32.936  1.00 81.72  ? 128 SER F OG  1 
ATOM   2531 N N   . LYS B 2 133 ? -71.662 -12.953 33.400  1.00 91.71  ? 129 LYS F N   1 
ATOM   2532 C CA  . LYS B 2 133 ? -70.389 -13.555 33.775  1.00 90.88  ? 129 LYS F CA  1 
ATOM   2533 C C   . LYS B 2 133 ? -69.252 -12.541 33.850  1.00 93.49  ? 129 LYS F C   1 
ATOM   2534 O O   . LYS B 2 133 ? -68.154 -12.896 34.296  1.00 81.50  ? 129 LYS F O   1 
ATOM   2535 C CB  . LYS B 2 133 ? -70.027 -14.668 32.786  1.00 69.37  ? 129 LYS F CB  1 
ATOM   2536 C CG  . LYS B 2 133 ? -70.184 -14.272 31.326  1.00 73.49  ? 129 LYS F CG  1 
ATOM   2537 C CD  . LYS B 2 133 ? -71.161 -15.194 30.603  1.00 82.66  ? 129 LYS F CD  1 
ATOM   2538 C CE  . LYS B 2 133 ? -71.305 -14.820 29.129  1.00 79.51  ? 129 LYS F CE  1 
ATOM   2539 N NZ  . LYS B 2 133 ? -72.310 -15.667 28.414  1.00 61.51  ? 129 LYS F NZ  1 
ATOM   2540 N N   . SER B 2 134 ? -69.491 -11.297 33.426  1.00 93.11  ? 130 SER F N   1 
ATOM   2541 C CA  . SER B 2 134 ? -68.488 -10.239 33.446  1.00 86.13  ? 130 SER F CA  1 
ATOM   2542 C C   . SER B 2 134 ? -68.882 -9.082  34.355  1.00 86.65  ? 130 SER F C   1 
ATOM   2543 O O   . SER B 2 134 ? -68.211 -8.040  34.346  1.00 78.97  ? 130 SER F O   1 
ATOM   2544 C CB  . SER B 2 134 ? -68.234 -9.725  32.021  1.00 77.81  ? 130 SER F CB  1 
ATOM   2545 O OG  . SER B 2 134 ? -68.037 -10.797 31.111  1.00 76.82  ? 130 SER F OG  1 
ATOM   2546 N N   . THR B 2 135 ? -69.957 -9.231  35.129  1.00 88.35  ? 131 THR F N   1 
ATOM   2547 C CA  . THR B 2 135 ? -70.432 -8.197  36.043  1.00 85.70  ? 131 THR F CA  1 
ATOM   2548 C C   . THR B 2 135 ? -70.560 -8.777  37.444  1.00 88.69  ? 131 THR F C   1 
ATOM   2549 O O   . THR B 2 135 ? -71.240 -9.795  37.639  1.00 82.04  ? 131 THR F O   1 
ATOM   2550 C CB  . THR B 2 135 ? -71.785 -7.630  35.592  1.00 85.33  ? 131 THR F CB  1 
ATOM   2551 O OG1 . THR B 2 135 ? -72.740 -8.693  35.473  1.00 85.13  ? 131 THR F OG1 1 
ATOM   2552 C CG2 . THR B 2 135 ? -71.646 -6.931  34.257  1.00 72.75  ? 131 THR F CG2 1 
ATOM   2553 N N   . SER B 2 136 ? -69.923 -8.119  38.414  1.00 92.88  ? 132 SER F N   1 
ATOM   2554 C CA  . SER B 2 136 ? -69.944 -8.556  39.804  1.00 92.01  ? 132 SER F CA  1 
ATOM   2555 C C   . SER B 2 136 ? -70.530 -7.450  40.662  1.00 91.44  ? 132 SER F C   1 
ATOM   2556 O O   . SER B 2 136 ? -70.035 -6.318  40.633  1.00 95.31  ? 132 SER F O   1 
ATOM   2557 C CB  . SER B 2 136 ? -68.537 -8.924  40.292  1.00 88.20  ? 132 SER F CB  1 
ATOM   2558 O OG  . SER B 2 136 ? -67.804 -7.766  40.669  1.00 91.53  ? 132 SER F OG  1 
ATOM   2559 N N   . GLY B 2 137 ? -71.567 -7.788  41.425  1.00 94.12  ? 133 GLY F N   1 
ATOM   2560 C CA  . GLY B 2 137 ? -72.242 -6.800  42.257  1.00 83.32  ? 133 GLY F CA  1 
ATOM   2561 C C   . GLY B 2 137 ? -72.785 -5.661  41.409  1.00 89.93  ? 133 GLY F C   1 
ATOM   2562 O O   . GLY B 2 137 ? -73.499 -5.880  40.424  1.00 88.86  ? 133 GLY F O   1 
ATOM   2563 N N   . GLY B 2 138 ? -72.439 -4.435  41.785  1.00 81.77  ? 134 GLY F N   1 
ATOM   2564 C CA  . GLY B 2 138 ? -72.759 -3.250  41.020  1.00 67.63  ? 134 GLY F CA  1 
ATOM   2565 C C   . GLY B 2 138 ? -71.731 -2.871  39.971  1.00 74.92  ? 134 GLY F C   1 
ATOM   2566 O O   . GLY B 2 138 ? -71.929 -1.907  39.222  1.00 84.28  ? 134 GLY F O   1 
ATOM   2567 N N   . THR B 2 139 ? -70.632 -3.627  39.888  1.00 80.41  ? 135 THR F N   1 
ATOM   2568 C CA  . THR B 2 139 ? -69.510 -3.300  39.015  1.00 81.42  ? 135 THR F CA  1 
ATOM   2569 C C   . THR B 2 139 ? -69.484 -4.207  37.783  1.00 74.46  ? 135 THR F C   1 
ATOM   2570 O O   . THR B 2 139 ? -69.758 -5.408  37.873  1.00 74.20  ? 135 THR F O   1 
ATOM   2571 C CB  . THR B 2 139 ? -68.186 -3.403  39.787  1.00 71.35  ? 135 THR F CB  1 
ATOM   2572 O OG1 . THR B 2 139 ? -68.007 -2.234  40.599  1.00 93.36  ? 135 THR F OG1 1 
ATOM   2573 C CG2 . THR B 2 139 ? -67.017 -3.532  38.835  1.00 60.17  ? 135 THR F CG2 1 
ATOM   2574 N N   . ALA B 2 140 ? -69.164 -3.624  36.628  1.00 70.89  ? 136 ALA F N   1 
ATOM   2575 C CA  . ALA B 2 140 ? -69.088 -4.360  35.373  1.00 69.16  ? 136 ALA F CA  1 
ATOM   2576 C C   . ALA B 2 140 ? -67.661 -4.350  34.843  1.00 69.02  ? 136 ALA F C   1 
ATOM   2577 O O   . ALA B 2 140 ? -66.873 -3.450  35.145  1.00 62.90  ? 136 ALA F O   1 
ATOM   2578 C CB  . ALA B 2 140 ? -70.030 -3.779  34.309  1.00 63.31  ? 136 ALA F CB  1 
ATOM   2579 N N   . ALA B 2 141 ? -67.326 -5.369  34.056  1.00 63.91  ? 137 ALA F N   1 
ATOM   2580 C CA  . ALA B 2 141 ? -66.002 -5.498  33.467  1.00 57.36  ? 137 ALA F CA  1 
ATOM   2581 C C   . ALA B 2 141 ? -66.147 -5.662  31.963  1.00 57.59  ? 137 ALA F C   1 
ATOM   2582 O O   . ALA B 2 141 ? -66.940 -6.487  31.498  1.00 61.51  ? 137 ALA F O   1 
ATOM   2583 C CB  . ALA B 2 141 ? -65.234 -6.680  34.071  1.00 64.51  ? 137 ALA F CB  1 
ATOM   2584 N N   . LEU B 2 142 ? -65.402 -4.859  31.207  1.00 43.43  ? 138 LEU F N   1 
ATOM   2585 C CA  . LEU B 2 142 ? -65.364 -4.953  29.756  1.00 52.65  ? 138 LEU F CA  1 
ATOM   2586 C C   . LEU B 2 142 ? -63.928 -4.751  29.305  1.00 57.55  ? 138 LEU F C   1 
ATOM   2587 O O   . LEU B 2 142 ? -63.045 -4.441  30.107  1.00 54.63  ? 138 LEU F O   1 
ATOM   2588 C CB  . LEU B 2 142 ? -66.285 -3.926  29.088  1.00 58.22  ? 138 LEU F CB  1 
ATOM   2589 C CG  . LEU B 2 142 ? -66.090 -2.484  29.551  1.00 63.20  ? 138 LEU F CG  1 
ATOM   2590 C CD1 . LEU B 2 142 ? -65.962 -1.543  28.368  1.00 55.91  ? 138 LEU F CD1 1 
ATOM   2591 C CD2 . LEU B 2 142 ? -67.242 -2.069  30.442  1.00 62.60  ? 138 LEU F CD2 1 
ATOM   2592 N N   . GLY B 2 143 ? -63.693 -4.925  28.010  1.00 55.06  ? 139 GLY F N   1 
ATOM   2593 C CA  . GLY B 2 143 ? -62.351 -4.744  27.490  1.00 53.99  ? 139 GLY F CA  1 
ATOM   2594 C C   . GLY B 2 143 ? -62.293 -5.016  26.004  1.00 51.73  ? 139 GLY F C   1 
ATOM   2595 O O   . GLY B 2 143 ? -63.307 -5.293  25.354  1.00 51.38  ? 139 GLY F O   1 
ATOM   2596 N N   . CYS B 2 144 ? -61.073 -4.926  25.474  1.00 48.37  ? 140 CYS F N   1 
ATOM   2597 C CA  . CYS B 2 144 ? -60.786 -5.201  24.075  1.00 48.30  ? 140 CYS F CA  1 
ATOM   2598 C C   . CYS B 2 144 ? -59.587 -6.130  23.972  1.00 45.76  ? 140 CYS F C   1 
ATOM   2599 O O   . CYS B 2 144 ? -58.675 -6.088  24.802  1.00 41.68  ? 140 CYS F O   1 
ATOM   2600 C CB  . CYS B 2 144 ? -60.507 -3.916  23.289  1.00 45.52  ? 140 CYS F CB  1 
ATOM   2601 S SG  . CYS B 2 144 ? -61.973 -2.912  23.018  1.00 106.63 ? 140 CYS F SG  1 
ATOM   2602 N N   . LEU B 2 145 ? -59.593 -6.965  22.938  1.00 45.01  ? 141 LEU F N   1 
ATOM   2603 C CA  . LEU B 2 145 ? -58.526 -7.929  22.693  1.00 41.89  ? 141 LEU F CA  1 
ATOM   2604 C C   . LEU B 2 145 ? -57.736 -7.484  21.468  1.00 42.69  ? 141 LEU F C   1 
ATOM   2605 O O   . LEU B 2 145 ? -58.268 -7.467  20.354  1.00 53.16  ? 141 LEU F O   1 
ATOM   2606 C CB  . LEU B 2 145 ? -59.099 -9.329  22.499  1.00 40.54  ? 141 LEU F CB  1 
ATOM   2607 C CG  . LEU B 2 145 ? -58.090 -10.431 22.183  1.00 41.93  ? 141 LEU F CG  1 
ATOM   2608 C CD1 . LEU B 2 145 ? -57.082 -10.560 23.313  1.00 38.59  ? 141 LEU F CD1 1 
ATOM   2609 C CD2 . LEU B 2 145 ? -58.805 -11.749 21.935  1.00 38.84  ? 141 LEU F CD2 1 
ATOM   2610 N N   . VAL B 2 146 ? -56.469 -7.138  21.672  1.00 36.87  ? 142 VAL F N   1 
ATOM   2611 C CA  . VAL B 2 146 ? -55.577 -6.727  20.594  1.00 37.62  ? 142 VAL F CA  1 
ATOM   2612 C C   . VAL B 2 146 ? -54.651 -7.897  20.298  1.00 39.02  ? 142 VAL F C   1 
ATOM   2613 O O   . VAL B 2 146 ? -53.706 -8.157  21.050  1.00 47.42  ? 142 VAL F O   1 
ATOM   2614 C CB  . VAL B 2 146 ? -54.781 -5.471  20.968  1.00 45.41  ? 142 VAL F CB  1 
ATOM   2615 C CG1 . VAL B 2 146 ? -54.173 -4.838  19.725  1.00 52.40  ? 142 VAL F CG1 1 
ATOM   2616 C CG2 . VAL B 2 146 ? -55.669 -4.485  21.706  1.00 40.51  ? 142 VAL F CG2 1 
ATOM   2617 N N   . LYS B 2 147 ? -54.905 -8.598  19.196  1.00 41.27  ? 143 LYS F N   1 
ATOM   2618 C CA  . LYS B 2 147 ? -54.252 -9.868  18.924  1.00 43.28  ? 143 LYS F CA  1 
ATOM   2619 C C   . LYS B 2 147 ? -53.576 -9.838  17.560  1.00 38.39  ? 143 LYS F C   1 
ATOM   2620 O O   . LYS B 2 147 ? -54.035 -9.165  16.633  1.00 43.91  ? 143 LYS F O   1 
ATOM   2621 C CB  . LYS B 2 147 ? -55.268 -11.031 19.003  1.00 40.81  ? 143 LYS F CB  1 
ATOM   2622 C CG  . LYS B 2 147 ? -54.684 -12.417 18.737  1.00 59.46  ? 143 LYS F CG  1 
ATOM   2623 C CD  . LYS B 2 147 ? -55.684 -13.532 19.031  1.00 49.74  ? 143 LYS F CD  1 
ATOM   2624 C CE  . LYS B 2 147 ? -55.101 -14.907 18.706  1.00 45.13  ? 143 LYS F CE  1 
ATOM   2625 N NZ  . LYS B 2 147 ? -54.899 -15.129 17.243  1.00 42.31  ? 143 LYS F NZ  1 
ATOM   2626 N N   . ASP B 2 148 ? -52.466 -10.574 17.459  1.00 49.45  ? 144 ASP F N   1 
ATOM   2627 C CA  . ASP B 2 148 ? -51.767 -10.834 16.199  1.00 52.81  ? 144 ASP F CA  1 
ATOM   2628 C C   . ASP B 2 148 ? -51.275 -9.546  15.534  1.00 57.39  ? 144 ASP F C   1 
ATOM   2629 O O   . ASP B 2 148 ? -51.703 -9.171  14.438  1.00 53.31  ? 144 ASP F O   1 
ATOM   2630 C CB  . ASP B 2 148 ? -52.654 -11.641 15.248  1.00 62.88  ? 144 ASP F CB  1 
ATOM   2631 C CG  . ASP B 2 148 ? -52.978 -13.015 15.788  1.00 56.06  ? 144 ASP F CG  1 
ATOM   2632 O OD1 . ASP B 2 148 ? -52.096 -13.624 16.432  1.00 58.16  ? 144 ASP F OD1 1 
ATOM   2633 O OD2 . ASP B 2 148 ? -54.116 -13.483 15.577  1.00 53.15  ? 144 ASP F OD2 1 
ATOM   2634 N N   . TYR B 2 149 ? -50.349 -8.875  16.218  1.00 52.73  ? 145 TYR F N   1 
ATOM   2635 C CA  . TYR B 2 149 ? -49.645 -7.731  15.660  1.00 53.28  ? 145 TYR F CA  1 
ATOM   2636 C C   . TYR B 2 149 ? -48.149 -7.896  15.878  1.00 43.74  ? 145 TYR F C   1 
ATOM   2637 O O   . TYR B 2 149 ? -47.710 -8.594  16.797  1.00 52.30  ? 145 TYR F O   1 
ATOM   2638 C CB  . TYR B 2 149 ? -50.122 -6.402  16.271  1.00 46.40  ? 145 TYR F CB  1 
ATOM   2639 C CG  . TYR B 2 149 ? -49.859 -6.248  17.754  1.00 44.66  ? 145 TYR F CG  1 
ATOM   2640 C CD1 . TYR B 2 149 ? -48.669 -5.699  18.215  1.00 37.99  ? 145 TYR F CD1 1 
ATOM   2641 C CD2 . TYR B 2 149 ? -50.809 -6.635  18.691  1.00 50.68  ? 145 TYR F CD2 1 
ATOM   2642 C CE1 . TYR B 2 149 ? -48.426 -5.551  19.569  1.00 44.67  ? 145 TYR F CE1 1 
ATOM   2643 C CE2 . TYR B 2 149 ? -50.575 -6.490  20.046  1.00 50.42  ? 145 TYR F CE2 1 
ATOM   2644 C CZ  . TYR B 2 149 ? -49.383 -5.947  20.478  1.00 44.68  ? 145 TYR F CZ  1 
ATOM   2645 O OH  . TYR B 2 149 ? -49.148 -5.800  21.825  1.00 45.55  ? 145 TYR F OH  1 
ATOM   2646 N N   . PHE B 2 150 ? -47.366 -7.246  15.014  1.00 48.44  ? 146 PHE F N   1 
ATOM   2647 C CA  . PHE B 2 150 ? -45.915 -7.270  15.117  1.00 50.16  ? 146 PHE F CA  1 
ATOM   2648 C C   . PHE B 2 150 ? -45.365 -6.077  14.358  1.00 51.41  ? 146 PHE F C   1 
ATOM   2649 O O   . PHE B 2 150 ? -45.858 -5.783  13.260  1.00 53.44  ? 146 PHE F O   1 
ATOM   2650 C CB  . PHE B 2 150 ? -45.335 -8.572  14.554  1.00 39.71  ? 146 PHE F CB  1 
ATOM   2651 C CG  . PHE B 2 150 ? -43.861 -8.741  14.799  1.00 48.20  ? 146 PHE F CG  1 
ATOM   2652 C CD1 . PHE B 2 150 ? -43.401 -9.305  15.979  1.00 44.09  ? 146 PHE F CD1 1 
ATOM   2653 C CD2 . PHE B 2 150 ? -42.935 -8.349  13.844  1.00 50.18  ? 146 PHE F CD2 1 
ATOM   2654 C CE1 . PHE B 2 150 ? -42.048 -9.467  16.205  1.00 37.83  ? 146 PHE F CE1 1 
ATOM   2655 C CE2 . PHE B 2 150 ? -41.578 -8.509  14.066  1.00 44.50  ? 146 PHE F CE2 1 
ATOM   2656 C CZ  . PHE B 2 150 ? -41.136 -9.068  15.246  1.00 36.93  ? 146 PHE F CZ  1 
ATOM   2657 N N   . PRO B 2 151 ? -44.373 -5.364  14.900  1.00 52.14  ? 147 PRO F N   1 
ATOM   2658 C CA  . PRO B 2 151 ? -43.778 -5.540  16.228  1.00 51.72  ? 147 PRO F CA  1 
ATOM   2659 C C   . PRO B 2 151 ? -44.452 -4.657  17.274  1.00 47.92  ? 147 PRO F C   1 
ATOM   2660 O O   . PRO B 2 151 ? -45.501 -4.071  17.024  1.00 42.75  ? 147 PRO F O   1 
ATOM   2661 C CB  . PRO B 2 151 ? -42.319 -5.141  15.988  1.00 43.97  ? 147 PRO F CB  1 
ATOM   2662 C CG  . PRO B 2 151 ? -42.429 -4.035  14.972  1.00 33.57  ? 147 PRO F CG  1 
ATOM   2663 C CD  . PRO B 2 151 ? -43.595 -4.414  14.082  1.00 44.27  ? 147 PRO F CD  1 
ATOM   2664 N N   . GLU B 2 152 ? -43.863 -4.562  18.463  1.00 49.61  ? 148 GLU F N   1 
ATOM   2665 C CA  . GLU B 2 152 ? -44.341 -3.649  19.485  1.00 53.34  ? 148 GLU F CA  1 
ATOM   2666 C C   . GLU B 2 152 ? -43.957 -2.211  19.132  1.00 56.56  ? 148 GLU F C   1 
ATOM   2667 O O   . GLU B 2 152 ? -43.042 -1.982  18.335  1.00 51.94  ? 148 GLU F O   1 
ATOM   2668 C CB  . GLU B 2 152 ? -43.766 -4.044  20.843  1.00 57.48  ? 148 GLU F CB  1 
ATOM   2669 C CG  . GLU B 2 152 ? -44.595 -5.082  21.576  1.00 57.60  ? 148 GLU F CG  1 
ATOM   2670 C CD  . GLU B 2 152 ? -43.949 -5.538  22.868  1.00 76.12  ? 148 GLU F CD  1 
ATOM   2671 O OE1 . GLU B 2 152 ? -42.784 -5.988  22.828  1.00 80.59  ? 148 GLU F OE1 1 
ATOM   2672 O OE2 . GLU B 2 152 ? -44.606 -5.443  23.926  1.00 64.72  ? 148 GLU F OE2 1 
ATOM   2673 N N   . PRO B 2 153 ? -44.638 -1.213  19.722  1.00 47.69  ? 149 PRO F N   1 
ATOM   2674 C CA  . PRO B 2 153 ? -45.708 -1.286  20.717  1.00 43.18  ? 149 PRO F CA  1 
ATOM   2675 C C   . PRO B 2 153 ? -47.090 -0.993  20.160  1.00 48.42  ? 149 PRO F C   1 
ATOM   2676 O O   . PRO B 2 153 ? -47.263 -0.654  18.994  1.00 53.03  ? 149 PRO F O   1 
ATOM   2677 C CB  . PRO B 2 153 ? -45.280 -0.214  21.727  1.00 46.12  ? 149 PRO F CB  1 
ATOM   2678 C CG  . PRO B 2 153 ? -44.520 0.827   20.885  1.00 50.39  ? 149 PRO F CG  1 
ATOM   2679 C CD  . PRO B 2 153 ? -44.214 0.184   19.540  1.00 43.77  ? 149 PRO F CD  1 
ATOM   2680 N N   . VAL B 2 154 ? -48.102 -1.130  21.010  1.00 42.28  ? 150 VAL F N   1 
ATOM   2681 C CA  . VAL B 2 154 ? -49.472 -0.754  20.693  1.00 45.13  ? 150 VAL F CA  1 
ATOM   2682 C C   . VAL B 2 154 ? -50.030 0.009   21.885  1.00 43.27  ? 150 VAL F C   1 
ATOM   2683 O O   . VAL B 2 154 ? -49.905 -0.445  23.028  1.00 52.29  ? 150 VAL F O   1 
ATOM   2684 C CB  . VAL B 2 154 ? -50.342 -1.984  20.367  1.00 49.28  ? 150 VAL F CB  1 
ATOM   2685 C CG1 . VAL B 2 154 ? -51.817 -1.652  20.514  1.00 44.74  ? 150 VAL F CG1 1 
ATOM   2686 C CG2 . VAL B 2 154 ? -50.045 -2.481  18.961  1.00 44.33  ? 150 VAL F CG2 1 
ATOM   2687 N N   . THR B 2 155 ? -50.623 1.169   21.624  1.00 47.61  ? 151 THR F N   1 
ATOM   2688 C CA  . THR B 2 155 ? -51.240 1.980   22.664  1.00 49.26  ? 151 THR F CA  1 
ATOM   2689 C C   . THR B 2 155 ? -52.755 1.818   22.613  1.00 44.04  ? 151 THR F C   1 
ATOM   2690 O O   . THR B 2 155 ? -53.344 1.722   21.532  1.00 47.46  ? 151 THR F O   1 
ATOM   2691 C CB  . THR B 2 155 ? -50.852 3.456   22.513  1.00 41.15  ? 151 THR F CB  1 
ATOM   2692 O OG1 . THR B 2 155 ? -51.516 4.235   23.515  1.00 62.72  ? 151 THR F OG1 1 
ATOM   2693 C CG2 . THR B 2 155 ? -51.225 3.984   21.130  1.00 47.23  ? 151 THR F CG2 1 
ATOM   2694 N N   . VAL B 2 156 ? -53.380 1.759   23.787  1.00 38.03  ? 152 VAL F N   1 
ATOM   2695 C CA  . VAL B 2 156 ? -54.824 1.595   23.903  1.00 50.37  ? 152 VAL F CA  1 
ATOM   2696 C C   . VAL B 2 156 ? -55.364 2.679   24.824  1.00 53.50  ? 152 VAL F C   1 
ATOM   2697 O O   . VAL B 2 156 ? -54.816 2.909   25.908  1.00 56.05  ? 152 VAL F O   1 
ATOM   2698 C CB  . VAL B 2 156 ? -55.209 0.198   24.430  1.00 50.00  ? 152 VAL F CB  1 
ATOM   2699 C CG1 . VAL B 2 156 ? -56.718 0.090   24.607  1.00 42.98  ? 152 VAL F CG1 1 
ATOM   2700 C CG2 . VAL B 2 156 ? -54.713 -0.883  23.484  1.00 49.50  ? 152 VAL F CG2 1 
ATOM   2701 N N   . SER B 2 157 ? -56.429 3.348   24.388  1.00 57.11  ? 153 SER F N   1 
ATOM   2702 C CA  . SER B 2 157 ? -57.119 4.343   25.195  1.00 56.22  ? 153 SER F CA  1 
ATOM   2703 C C   . SER B 2 157 ? -58.619 4.115   25.074  1.00 65.13  ? 153 SER F C   1 
ATOM   2704 O O   . SER B 2 157 ? -59.102 3.528   24.102  1.00 68.30  ? 153 SER F O   1 
ATOM   2705 C CB  . SER B 2 157 ? -56.755 5.773   24.769  1.00 77.44  ? 153 SER F CB  1 
ATOM   2706 O OG  . SER B 2 157 ? -57.101 6.014   23.417  1.00 74.14  ? 153 SER F OG  1 
ATOM   2707 N N   . TRP B 2 158 ? -59.357 4.579   26.079  1.00 67.38  ? 154 TRP F N   1 
ATOM   2708 C CA  . TRP B 2 158 ? -60.801 4.397   26.136  1.00 77.97  ? 154 TRP F CA  1 
ATOM   2709 C C   . TRP B 2 158 ? -61.498 5.748   26.059  1.00 76.77  ? 154 TRP F C   1 
ATOM   2710 O O   . TRP B 2 158 ? -61.189 6.655   26.840  1.00 71.27  ? 154 TRP F O   1 
ATOM   2711 C CB  . TRP B 2 158 ? -61.209 3.654   27.409  1.00 76.58  ? 154 TRP F CB  1 
ATOM   2712 C CG  . TRP B 2 158 ? -60.856 2.205   27.365  1.00 75.73  ? 154 TRP F CG  1 
ATOM   2713 C CD1 . TRP B 2 158 ? -59.667 1.639   27.723  1.00 72.31  ? 154 TRP F CD1 1 
ATOM   2714 C CD2 . TRP B 2 158 ? -61.695 1.133   26.923  1.00 73.26  ? 154 TRP F CD2 1 
ATOM   2715 N NE1 . TRP B 2 158 ? -59.717 0.278   27.538  1.00 64.96  ? 154 TRP F NE1 1 
ATOM   2716 C CE2 . TRP B 2 158 ? -60.952 -0.057  27.047  1.00 75.32  ? 154 TRP F CE2 1 
ATOM   2717 C CE3 . TRP B 2 158 ? -63.004 1.064   26.438  1.00 67.31  ? 154 TRP F CE3 1 
ATOM   2718 C CZ2 . TRP B 2 158 ? -61.474 -1.302  26.704  1.00 71.11  ? 154 TRP F CZ2 1 
ATOM   2719 C CZ3 . TRP B 2 158 ? -63.521 -0.171  26.097  1.00 72.54  ? 154 TRP F CZ3 1 
ATOM   2720 C CH2 . TRP B 2 158 ? -62.758 -1.337  26.232  1.00 75.73  ? 154 TRP F CH2 1 
ATOM   2721 N N   . ASN B 2 159 ? -62.447 5.866   25.123  1.00 72.27  ? 155 ASN F N   1 
ATOM   2722 C CA  . ASN B 2 159 ? -63.177 7.111   24.873  1.00 66.38  ? 155 ASN F CA  1 
ATOM   2723 C C   . ASN B 2 159 ? -62.222 8.267   24.577  1.00 77.77  ? 155 ASN F C   1 
ATOM   2724 O O   . ASN B 2 159 ? -62.395 9.382   25.075  1.00 67.09  ? 155 ASN F O   1 
ATOM   2725 C CB  . ASN B 2 159 ? -64.107 7.452   26.040  1.00 57.72  ? 155 ASN F CB  1 
ATOM   2726 C CG  . ASN B 2 159 ? -65.175 6.400   26.256  1.00 63.75  ? 155 ASN F CG  1 
ATOM   2727 O OD1 . ASN B 2 159 ? -65.530 5.665   25.335  1.00 67.09  ? 155 ASN F OD1 1 
ATOM   2728 N ND2 . ASN B 2 159 ? -65.692 6.320   27.476  1.00 57.77  ? 155 ASN F ND2 1 
ATOM   2729 N N   . SER B 2 160 ? -61.205 7.991   23.756  1.00 82.73  ? 156 SER F N   1 
ATOM   2730 C CA  . SER B 2 160 ? -60.199 8.982   23.357  1.00 72.66  ? 156 SER F CA  1 
ATOM   2731 C C   . SER B 2 160 ? -59.542 9.644   24.566  1.00 70.89  ? 156 SER F C   1 
ATOM   2732 O O   . SER B 2 160 ? -59.321 10.855  24.587  1.00 88.12  ? 156 SER F O   1 
ATOM   2733 C CB  . SER B 2 160 ? -60.795 10.035  22.420  1.00 67.38  ? 156 SER F CB  1 
ATOM   2734 O OG  . SER B 2 160 ? -61.279 9.441   21.227  1.00 55.72  ? 156 SER F OG  1 
ATOM   2735 N N   . GLY B 2 161 ? -59.223 8.844   25.583  1.00 76.52  ? 157 GLY F N   1 
ATOM   2736 C CA  . GLY B 2 161 ? -58.593 9.352   26.782  1.00 73.61  ? 157 GLY F CA  1 
ATOM   2737 C C   . GLY B 2 161 ? -59.535 9.891   27.835  1.00 71.33  ? 157 GLY F C   1 
ATOM   2738 O O   . GLY B 2 161 ? -59.064 10.306  28.901  1.00 66.35  ? 157 GLY F O   1 
ATOM   2739 N N   . ALA B 2 162 ? -60.847 9.891   27.583  1.00 69.53  ? 158 ALA F N   1 
ATOM   2740 C CA  . ALA B 2 162 ? -61.792 10.404  28.571  1.00 67.24  ? 158 ALA F CA  1 
ATOM   2741 C C   . ALA B 2 162 ? -61.917 9.477   29.774  1.00 74.52  ? 158 ALA F C   1 
ATOM   2742 O O   . ALA B 2 162 ? -62.187 9.945   30.886  1.00 81.92  ? 158 ALA F O   1 
ATOM   2743 C CB  . ALA B 2 162 ? -63.162 10.620  27.931  1.00 59.97  ? 158 ALA F CB  1 
ATOM   2744 N N   . LEU B 2 163 ? -61.740 8.172   29.575  1.00 75.49  ? 159 LEU F N   1 
ATOM   2745 C CA  . LEU B 2 163 ? -61.857 7.182   30.641  1.00 65.24  ? 159 LEU F CA  1 
ATOM   2746 C C   . LEU B 2 163 ? -60.458 6.695   30.994  1.00 64.53  ? 159 LEU F C   1 
ATOM   2747 O O   . LEU B 2 163 ? -59.799 6.039   30.180  1.00 65.73  ? 159 LEU F O   1 
ATOM   2748 C CB  . LEU B 2 163 ? -62.762 6.027   30.215  1.00 55.53  ? 159 LEU F CB  1 
ATOM   2749 C CG  . LEU B 2 163 ? -63.264 5.079   31.308  1.00 51.49  ? 159 LEU F CG  1 
ATOM   2750 C CD1 . LEU B 2 163 ? -64.623 4.511   30.931  1.00 49.86  ? 159 LEU F CD1 1 
ATOM   2751 C CD2 . LEU B 2 163 ? -62.273 3.953   31.557  1.00 78.85  ? 159 LEU F CD2 1 
ATOM   2752 N N   . THR B 2 164 ? -60.001 7.029   32.202  1.00 68.42  ? 160 THR F N   1 
ATOM   2753 C CA  . THR B 2 164 ? -58.694 6.608   32.683  1.00 72.82  ? 160 THR F CA  1 
ATOM   2754 C C   . THR B 2 164 ? -58.742 5.894   34.025  1.00 75.63  ? 160 THR F C   1 
ATOM   2755 O O   . THR B 2 164 ? -57.756 5.246   34.395  1.00 81.86  ? 160 THR F O   1 
ATOM   2756 C CB  . THR B 2 164 ? -57.743 7.810   32.805  1.00 69.89  ? 160 THR F CB  1 
ATOM   2757 O OG1 . THR B 2 164 ? -58.173 8.656   33.878  1.00 84.14  ? 160 THR F OG1 1 
ATOM   2758 C CG2 . THR B 2 164 ? -57.707 8.611   31.509  1.00 76.09  ? 160 THR F CG2 1 
ATOM   2759 N N   . SER B 2 165 ? -59.841 6.000   34.765  1.00 72.23  ? 161 SER F N   1 
ATOM   2760 C CA  . SER B 2 165 ? -59.952 5.377   36.074  1.00 67.21  ? 161 SER F CA  1 
ATOM   2761 C C   . SER B 2 165 ? -60.471 3.957   35.918  1.00 71.22  ? 161 SER F C   1 
ATOM   2762 O O   . SER B 2 165 ? -61.507 3.732   35.284  1.00 79.73  ? 161 SER F O   1 
ATOM   2763 C CB  . SER B 2 165 ? -60.880 6.186   36.981  1.00 67.44  ? 161 SER F CB  1 
ATOM   2764 O OG  . SER B 2 165 ? -60.378 7.495   37.187  1.00 84.01  ? 161 SER F OG  1 
ATOM   2765 N N   . GLY B 2 166 ? -59.748 3.003   36.499  1.00 80.46  ? 162 GLY F N   1 
ATOM   2766 C CA  . GLY B 2 166 ? -60.135 1.611   36.428  1.00 82.74  ? 162 GLY F CA  1 
ATOM   2767 C C   . GLY B 2 166 ? -59.684 0.879   35.188  1.00 71.85  ? 162 GLY F C   1 
ATOM   2768 O O   . GLY B 2 166 ? -60.106 -0.264  34.979  1.00 69.65  ? 162 GLY F O   1 
ATOM   2769 N N   . VAL B 2 167 ? -58.845 1.492   34.361  1.00 58.24  ? 163 VAL F N   1 
ATOM   2770 C CA  . VAL B 2 167 ? -58.346 0.856   33.149  1.00 59.04  ? 163 VAL F CA  1 
ATOM   2771 C C   . VAL B 2 167 ? -57.075 0.084   33.480  1.00 59.07  ? 163 VAL F C   1 
ATOM   2772 O O   . VAL B 2 167 ? -56.211 0.559   34.227  1.00 55.93  ? 163 VAL F O   1 
ATOM   2773 C CB  . VAL B 2 167 ? -58.109 1.898   32.036  1.00 62.66  ? 163 VAL F CB  1 
ATOM   2774 C CG1 . VAL B 2 167 ? -57.061 2.918   32.453  1.00 65.86  ? 163 VAL F CG1 1 
ATOM   2775 C CG2 . VAL B 2 167 ? -57.704 1.216   30.739  1.00 60.61  ? 163 VAL F CG2 1 
ATOM   2776 N N   . HIS B 2 168 ? -56.975 -1.130  32.943  1.00 67.97  ? 164 HIS F N   1 
ATOM   2777 C CA  . HIS B 2 168 ? -55.800 -1.979  33.107  1.00 49.90  ? 164 HIS F CA  1 
ATOM   2778 C C   . HIS B 2 168 ? -55.419 -2.526  31.740  1.00 42.35  ? 164 HIS F C   1 
ATOM   2779 O O   . HIS B 2 168 ? -56.150 -3.344  31.171  1.00 50.96  ? 164 HIS F O   1 
ATOM   2780 C CB  . HIS B 2 168 ? -56.069 -3.121  34.087  1.00 48.74  ? 164 HIS F CB  1 
ATOM   2781 C CG  . HIS B 2 168 ? -56.278 -2.674  35.500  1.00 49.92  ? 164 HIS F CG  1 
ATOM   2782 N ND1 . HIS B 2 168 ? -55.234 -2.337  36.336  1.00 51.22  ? 164 HIS F ND1 1 
ATOM   2783 C CD2 . HIS B 2 168 ? -57.409 -2.523  36.229  1.00 44.72  ? 164 HIS F CD2 1 
ATOM   2784 C CE1 . HIS B 2 168 ? -55.714 -1.991  37.517  1.00 62.53  ? 164 HIS F CE1 1 
ATOM   2785 N NE2 . HIS B 2 168 ? -57.031 -2.096  37.479  1.00 58.14  ? 164 HIS F NE2 1 
ATOM   2786 N N   . THR B 2 169 ? -54.280 -2.084  31.214  1.00 34.31  ? 165 THR F N   1 
ATOM   2787 C CA  . THR B 2 169 ? -53.759 -2.568  29.940  1.00 41.64  ? 165 THR F CA  1 
ATOM   2788 C C   . THR B 2 169 ? -52.565 -3.472  30.219  1.00 41.81  ? 165 THR F C   1 
ATOM   2789 O O   . THR B 2 169 ? -51.522 -3.008  30.692  1.00 41.91  ? 165 THR F O   1 
ATOM   2790 C CB  . THR B 2 169 ? -53.368 -1.411  29.026  1.00 42.67  ? 165 THR F CB  1 
ATOM   2791 O OG1 . THR B 2 169 ? -54.526 -0.616  28.745  1.00 44.50  ? 165 THR F OG1 1 
ATOM   2792 C CG2 . THR B 2 169 ? -52.799 -1.945  27.722  1.00 47.24  ? 165 THR F CG2 1 
ATOM   2793 N N   . PHE B 2 170 ? -52.718 -4.751  29.918  1.00 41.90  ? 166 PHE F N   1 
ATOM   2794 C CA  . PHE B 2 170 ? -51.706 -5.735  30.253  1.00 44.22  ? 166 PHE F CA  1 
ATOM   2795 C C   . PHE B 2 170 ? -50.526 -5.668  29.286  1.00 44.42  ? 166 PHE F C   1 
ATOM   2796 O O   . PHE B 2 170 ? -50.689 -5.307  28.118  1.00 39.28  ? 166 PHE F O   1 
ATOM   2797 C CB  . PHE B 2 170 ? -52.308 -7.134  30.235  1.00 35.80  ? 166 PHE F CB  1 
ATOM   2798 C CG  . PHE B 2 170 ? -53.430 -7.320  31.215  1.00 36.81  ? 166 PHE F CG  1 
ATOM   2799 C CD1 . PHE B 2 170 ? -53.174 -7.737  32.508  1.00 36.05  ? 166 PHE F CD1 1 
ATOM   2800 C CD2 . PHE B 2 170 ? -54.741 -7.075  30.844  1.00 43.14  ? 166 PHE F CD2 1 
ATOM   2801 C CE1 . PHE B 2 170 ? -54.201 -7.906  33.413  1.00 43.83  ? 166 PHE F CE1 1 
ATOM   2802 C CE2 . PHE B 2 170 ? -55.775 -7.243  31.744  1.00 45.81  ? 166 PHE F CE2 1 
ATOM   2803 C CZ  . PHE B 2 170 ? -55.503 -7.659  33.030  1.00 51.76  ? 166 PHE F CZ  1 
ATOM   2804 N N   . PRO B 2 171 ? -49.324 -5.998  29.761  1.00 46.21  ? 167 PRO F N   1 
ATOM   2805 C CA  . PRO B 2 171 ? -48.170 -6.075  28.858  1.00 42.32  ? 167 PRO F CA  1 
ATOM   2806 C C   . PRO B 2 171 ? -48.375 -7.130  27.781  1.00 46.79  ? 167 PRO F C   1 
ATOM   2807 O O   . PRO B 2 171 ? -48.993 -8.173  28.008  1.00 49.81  ? 167 PRO F O   1 
ATOM   2808 C CB  . PRO B 2 171 ? -47.013 -6.447  29.792  1.00 37.09  ? 167 PRO F CB  1 
ATOM   2809 C CG  . PRO B 2 171 ? -47.448 -5.981  31.138  1.00 32.92  ? 167 PRO F CG  1 
ATOM   2810 C CD  . PRO B 2 171 ? -48.937 -6.150  31.174  1.00 34.49  ? 167 PRO F CD  1 
ATOM   2811 N N   . ALA B 2 172 ? -47.837 -6.848  26.597  1.00 43.35  ? 168 ALA F N   1 
ATOM   2812 C CA  . ALA B 2 172 ? -47.980 -7.765  25.476  1.00 43.87  ? 168 ALA F CA  1 
ATOM   2813 C C   . ALA B 2 172 ? -47.276 -9.085  25.769  1.00 48.48  ? 168 ALA F C   1 
ATOM   2814 O O   . ALA B 2 172 ? -46.243 -9.125  26.444  1.00 50.36  ? 168 ALA F O   1 
ATOM   2815 C CB  . ALA B 2 172 ? -47.411 -7.137  24.202  1.00 40.43  ? 168 ALA F CB  1 
ATOM   2816 N N   . VAL B 2 173 ? -47.852 -10.174 25.270  1.00 47.81  ? 169 VAL F N   1 
ATOM   2817 C CA  . VAL B 2 173 ? -47.285 -11.508 25.418  1.00 42.26  ? 169 VAL F CA  1 
ATOM   2818 C C   . VAL B 2 173 ? -47.037 -12.072 24.025  1.00 45.70  ? 169 VAL F C   1 
ATOM   2819 O O   . VAL B 2 173 ? -47.936 -12.063 23.175  1.00 43.92  ? 169 VAL F O   1 
ATOM   2820 C CB  . VAL B 2 173 ? -48.208 -12.436 26.230  1.00 42.74  ? 169 VAL F CB  1 
ATOM   2821 C CG1 . VAL B 2 173 ? -47.566 -13.812 26.412  1.00 36.52  ? 169 VAL F CG1 1 
ATOM   2822 C CG2 . VAL B 2 173 ? -48.536 -11.810 27.578  1.00 53.48  ? 169 VAL F CG2 1 
ATOM   2823 N N   . LEU B 2 174 ? -45.821 -12.556 23.791  1.00 44.90  ? 170 LEU F N   1 
ATOM   2824 C CA  . LEU B 2 174 ? -45.480 -13.152 22.506  1.00 40.35  ? 170 LEU F CA  1 
ATOM   2825 C C   . LEU B 2 174 ? -46.085 -14.547 22.422  1.00 51.39  ? 170 LEU F C   1 
ATOM   2826 O O   . LEU B 2 174 ? -45.717 -15.437 23.196  1.00 67.33  ? 170 LEU F O   1 
ATOM   2827 C CB  . LEU B 2 174 ? -43.965 -13.209 22.329  1.00 41.59  ? 170 LEU F CB  1 
ATOM   2828 C CG  . LEU B 2 174 ? -43.452 -13.739 20.989  1.00 45.09  ? 170 LEU F CG  1 
ATOM   2829 C CD1 . LEU B 2 174 ? -43.906 -12.833 19.863  1.00 46.90  ? 170 LEU F CD1 1 
ATOM   2830 C CD2 . LEU B 2 174 ? -41.940 -13.851 21.010  1.00 52.51  ? 170 LEU F CD2 1 
ATOM   2831 N N   . GLN B 2 175 ? -47.015 -14.737 21.491  1.00 56.02  ? 171 GLN F N   1 
ATOM   2832 C CA  . GLN B 2 175 ? -47.651 -16.031 21.306  1.00 50.62  ? 171 GLN F CA  1 
ATOM   2833 C C   . GLN B 2 175 ? -46.723 -16.986 20.559  1.00 55.55  ? 171 GLN F C   1 
ATOM   2834 O O   . GLN B 2 175 ? -45.666 -16.604 20.050  1.00 56.51  ? 171 GLN F O   1 
ATOM   2835 C CB  . GLN B 2 175 ? -48.965 -15.876 20.549  1.00 54.66  ? 171 GLN F CB  1 
ATOM   2836 C CG  . GLN B 2 175 ? -49.917 -14.886 21.178  1.00 48.76  ? 171 GLN F CG  1 
ATOM   2837 C CD  . GLN B 2 175 ? -51.233 -14.824 20.444  1.00 63.33  ? 171 GLN F CD  1 
ATOM   2838 O OE1 . GLN B 2 175 ? -51.473 -13.913 19.651  1.00 57.15  ? 171 GLN F OE1 1 
ATOM   2839 N NE2 . GLN B 2 175 ? -52.097 -15.801 20.697  1.00 61.07  ? 171 GLN F NE2 1 
ATOM   2840 N N   . SER B 2 176 ? -47.139 -18.254 20.493  1.00 51.07  ? 172 SER F N   1 
ATOM   2841 C CA  . SER B 2 176 ? -46.344 -19.270 19.812  1.00 65.60  ? 172 SER F CA  1 
ATOM   2842 C C   . SER B 2 176 ? -46.267 -19.053 18.305  1.00 52.55  ? 172 SER F C   1 
ATOM   2843 O O   . SER B 2 176 ? -45.418 -19.668 17.651  1.00 44.74  ? 172 SER F O   1 
ATOM   2844 C CB  . SER B 2 176 ? -46.904 -20.665 20.114  1.00 49.79  ? 172 SER F CB  1 
ATOM   2845 O OG  . SER B 2 176 ? -48.287 -20.748 19.821  1.00 49.08  ? 172 SER F OG  1 
ATOM   2846 N N   . SER B 2 177 ? -47.112 -18.191 17.748  1.00 47.99  ? 173 SER F N   1 
ATOM   2847 C CA  . SER B 2 177 ? -47.119 -17.899 16.322  1.00 43.27  ? 173 SER F CA  1 
ATOM   2848 C C   . SER B 2 177 ? -46.114 -16.826 15.927  1.00 51.56  ? 173 SER F C   1 
ATOM   2849 O O   . SER B 2 177 ? -46.022 -16.492 14.742  1.00 59.04  ? 173 SER F O   1 
ATOM   2850 C CB  . SER B 2 177 ? -48.517 -17.463 15.888  1.00 44.79  ? 173 SER F CB  1 
ATOM   2851 O OG  . SER B 2 177 ? -48.937 -16.342 16.644  1.00 57.37  ? 173 SER F OG  1 
ATOM   2852 N N   . GLY B 2 178 ? -45.368 -16.275 16.881  1.00 57.98  ? 174 GLY F N   1 
ATOM   2853 C CA  . GLY B 2 178 ? -44.435 -15.206 16.597  1.00 50.88  ? 174 GLY F CA  1 
ATOM   2854 C C   . GLY B 2 178 ? -45.031 -13.817 16.603  1.00 52.99  ? 174 GLY F C   1 
ATOM   2855 O O   . GLY B 2 178 ? -44.317 -12.854 16.294  1.00 57.52  ? 174 GLY F O   1 
ATOM   2856 N N   . LEU B 2 179 ? -46.310 -13.680 16.941  1.00 49.51  ? 175 LEU F N   1 
ATOM   2857 C CA  . LEU B 2 179 ? -46.992 -12.397 16.998  1.00 41.47  ? 175 LEU F CA  1 
ATOM   2858 C C   . LEU B 2 179 ? -47.336 -12.050 18.440  1.00 45.23  ? 175 LEU F C   1 
ATOM   2859 O O   . LEU B 2 179 ? -47.364 -12.911 19.323  1.00 49.41  ? 175 LEU F O   1 
ATOM   2860 C CB  . LEU B 2 179 ? -48.267 -12.418 16.150  1.00 52.24  ? 175 LEU F CB  1 
ATOM   2861 C CG  . LEU B 2 179 ? -48.092 -12.843 14.694  1.00 48.99  ? 175 LEU F CG  1 
ATOM   2862 C CD1 . LEU B 2 179 ? -49.443 -12.892 14.002  1.00 45.26  ? 175 LEU F CD1 1 
ATOM   2863 C CD2 . LEU B 2 179 ? -47.135 -11.905 13.966  1.00 41.77  ? 175 LEU F CD2 1 
ATOM   2864 N N   . TYR B 2 180 ? -47.608 -10.770 18.668  1.00 42.08  ? 176 TYR F N   1 
ATOM   2865 C CA  . TYR B 2 180 ? -47.937 -10.273 19.993  1.00 37.98  ? 176 TYR F CA  1 
ATOM   2866 C C   . TYR B 2 180 ? -49.445 -10.184 20.176  1.00 41.98  ? 176 TYR F C   1 
ATOM   2867 O O   . TYR B 2 180 ? -50.195 -9.960  19.223  1.00 50.12  ? 176 TYR F O   1 
ATOM   2868 C CB  . TYR B 2 180 ? -47.315 -8.898  20.236  1.00 37.75  ? 176 TYR F CB  1 
ATOM   2869 C CG  . TYR B 2 180 ? -45.819 -8.920  20.408  1.00 42.73  ? 176 TYR F CG  1 
ATOM   2870 C CD1 . TYR B 2 180 ? -45.250 -9.297  21.615  1.00 53.15  ? 176 TYR F CD1 1 
ATOM   2871 C CD2 . TYR B 2 180 ? -44.973 -8.555  19.368  1.00 45.62  ? 176 TYR F CD2 1 
ATOM   2872 C CE1 . TYR B 2 180 ? -43.880 -9.317  21.783  1.00 59.21  ? 176 TYR F CE1 1 
ATOM   2873 C CE2 . TYR B 2 180 ? -43.601 -8.571  19.527  1.00 57.55  ? 176 TYR F CE2 1 
ATOM   2874 C CZ  . TYR B 2 180 ? -43.060 -8.954  20.739  1.00 54.59  ? 176 TYR F CZ  1 
ATOM   2875 O OH  . TYR B 2 180 ? -41.696 -8.977  20.918  1.00 51.32  ? 176 TYR F OH  1 
ATOM   2876 N N   . SER B 2 181 ? -49.881 -10.369 21.418  1.00 43.66  ? 177 SER F N   1 
ATOM   2877 C CA  . SER B 2 181 ? -51.278 -10.217 21.788  1.00 37.56  ? 177 SER F CA  1 
ATOM   2878 C C   . SER B 2 181 ? -51.368 -9.419  23.079  1.00 35.20  ? 177 SER F C   1 
ATOM   2879 O O   . SER B 2 181 ? -50.469 -9.466  23.923  1.00 36.08  ? 177 SER F O   1 
ATOM   2880 C CB  . SER B 2 181 ? -51.971 -11.572 21.953  1.00 48.93  ? 177 SER F CB  1 
ATOM   2881 O OG  . SER B 2 181 ? -53.349 -11.398 22.225  1.00 49.40  ? 177 SER F OG  1 
ATOM   2882 N N   . LEU B 2 182 ? -52.463 -8.680  23.223  1.00 35.49  ? 178 LEU F N   1 
ATOM   2883 C CA  . LEU B 2 182 ? -52.617 -7.768  24.344  1.00 33.74  ? 178 LEU F CA  1 
ATOM   2884 C C   . LEU B 2 182 ? -54.094 -7.658  24.683  1.00 35.91  ? 178 LEU F C   1 
ATOM   2885 O O   . LEU B 2 182 ? -54.960 -7.853  23.826  1.00 48.02  ? 178 LEU F O   1 
ATOM   2886 C CB  . LEU B 2 182 ? -52.016 -6.392  24.013  1.00 40.92  ? 178 LEU F CB  1 
ATOM   2887 C CG  . LEU B 2 182 ? -52.008 -5.257  25.041  1.00 46.98  ? 178 LEU F CG  1 
ATOM   2888 C CD1 . LEU B 2 182 ? -50.767 -4.395  24.858  1.00 50.03  ? 178 LEU F CD1 1 
ATOM   2889 C CD2 . LEU B 2 182 ? -53.261 -4.396  24.930  1.00 44.23  ? 178 LEU F CD2 1 
ATOM   2890 N N   . SER B 2 183 ? -54.373 -7.352  25.945  1.00 36.17  ? 179 SER F N   1 
ATOM   2891 C CA  . SER B 2 183 ? -55.731 -7.131  26.415  1.00 41.40  ? 179 SER F CA  1 
ATOM   2892 C C   . SER B 2 183 ? -55.760 -5.885  27.285  1.00 50.99  ? 179 SER F C   1 
ATOM   2893 O O   . SER B 2 183 ? -54.848 -5.654  28.084  1.00 56.84  ? 179 SER F O   1 
ATOM   2894 C CB  . SER B 2 183 ? -56.258 -8.339  27.203  1.00 45.56  ? 179 SER F CB  1 
ATOM   2895 O OG  . SER B 2 183 ? -56.324 -9.498  26.389  1.00 57.16  ? 179 SER F OG  1 
ATOM   2896 N N   . SER B 2 184 ? -56.803 -5.078  27.115  1.00 46.41  ? 180 SER F N   1 
ATOM   2897 C CA  . SER B 2 184 ? -57.018 -3.884  27.920  1.00 52.37  ? 180 SER F CA  1 
ATOM   2898 C C   . SER B 2 184 ? -58.453 -3.895  28.418  1.00 48.01  ? 180 SER F C   1 
ATOM   2899 O O   . SER B 2 184 ? -59.384 -4.036  27.620  1.00 45.22  ? 180 SER F O   1 
ATOM   2900 C CB  . SER B 2 184 ? -56.736 -2.612  27.111  1.00 45.03  ? 180 SER F CB  1 
ATOM   2901 O OG  . SER B 2 184 ? -57.020 -1.450  27.869  1.00 49.94  ? 180 SER F OG  1 
ATOM   2902 N N   . VAL B 2 185 ? -58.630 -3.745  29.729  1.00 47.36  ? 181 VAL F N   1 
ATOM   2903 C CA  . VAL B 2 185 ? -59.942 -3.828  30.357  1.00 51.67  ? 181 VAL F CA  1 
ATOM   2904 C C   . VAL B 2 185 ? -60.162 -2.605  31.236  1.00 57.92  ? 181 VAL F C   1 
ATOM   2905 O O   . VAL B 2 185 ? -59.211 -1.987  31.725  1.00 57.95  ? 181 VAL F O   1 
ATOM   2906 C CB  . VAL B 2 185 ? -60.097 -5.126  31.182  1.00 53.86  ? 181 VAL F CB  1 
ATOM   2907 C CG1 . VAL B 2 185 ? -60.098 -6.344  30.267  1.00 49.36  ? 181 VAL F CG1 1 
ATOM   2908 C CG2 . VAL B 2 185 ? -58.987 -5.234  32.215  1.00 42.77  ? 181 VAL F CG2 1 
ATOM   2909 N N   . VAL B 2 186 ? -61.437 -2.252  31.424  1.00 63.51  ? 182 VAL F N   1 
ATOM   2910 C CA  . VAL B 2 186 ? -61.838 -1.168  32.309  1.00 65.88  ? 182 VAL F CA  1 
ATOM   2911 C C   . VAL B 2 186 ? -62.942 -1.669  33.232  1.00 59.24  ? 182 VAL F C   1 
ATOM   2912 O O   . VAL B 2 186 ? -63.604 -2.677  32.969  1.00 55.30  ? 182 VAL F O   1 
ATOM   2913 C CB  . VAL B 2 186 ? -62.314 0.096   31.555  1.00 66.89  ? 182 VAL F CB  1 
ATOM   2914 C CG1 . VAL B 2 186 ? -61.292 0.523   30.520  1.00 74.80  ? 182 VAL F CG1 1 
ATOM   2915 C CG2 . VAL B 2 186 ? -63.669 -0.135  30.921  1.00 58.52  ? 182 VAL F CG2 1 
ATOM   2916 N N   . THR B 2 187 ? -63.124 -0.938  34.329  1.00 68.82  ? 183 THR F N   1 
ATOM   2917 C CA  . THR B 2 187 ? -64.051 -1.291  35.396  1.00 66.64  ? 183 THR F CA  1 
ATOM   2918 C C   . THR B 2 187 ? -65.071 -0.163  35.528  1.00 63.94  ? 183 THR F C   1 
ATOM   2919 O O   . THR B 2 187 ? -64.725 0.951   35.936  1.00 73.02  ? 183 THR F O   1 
ATOM   2920 C CB  . THR B 2 187 ? -63.296 -1.531  36.706  1.00 71.55  ? 183 THR F CB  1 
ATOM   2921 O OG1 . THR B 2 187 ? -62.036 -2.162  36.424  1.00 75.00  ? 183 THR F OG1 1 
ATOM   2922 C CG2 . THR B 2 187 ? -64.095 -2.426  37.617  1.00 52.27  ? 183 THR F CG2 1 
ATOM   2923 N N   . VAL B 2 188 ? -66.320 -0.446  35.169  1.00 67.51  ? 184 VAL F N   1 
ATOM   2924 C CA  . VAL B 2 188 ? -67.364 0.578   35.158  1.00 60.42  ? 184 VAL F CA  1 
ATOM   2925 C C   . VAL B 2 188 ? -68.569 0.055   35.929  1.00 67.52  ? 184 VAL F C   1 
ATOM   2926 O O   . VAL B 2 188 ? -68.747 -1.164  36.081  1.00 81.35  ? 184 VAL F O   1 
ATOM   2927 C CB  . VAL B 2 188 ? -67.764 0.972   33.717  1.00 57.78  ? 184 VAL F CB  1 
ATOM   2928 C CG1 . VAL B 2 188 ? -66.532 1.256   32.871  1.00 58.98  ? 184 VAL F CG1 1 
ATOM   2929 C CG2 . VAL B 2 188 ? -68.626 -0.108  33.091  1.00 61.17  ? 184 VAL F CG2 1 
ATOM   2930 N N   . PRO B 2 189 ? -69.411 0.955   36.443  1.00 76.07  ? 185 PRO F N   1 
ATOM   2931 C CA  . PRO B 2 189 ? -70.636 0.509   37.119  1.00 77.32  ? 185 PRO F CA  1 
ATOM   2932 C C   . PRO B 2 189 ? -71.567 -0.217  36.161  1.00 78.29  ? 185 PRO F C   1 
ATOM   2933 O O   . PRO B 2 189 ? -71.637 0.094   34.970  1.00 74.73  ? 185 PRO F O   1 
ATOM   2934 C CB  . PRO B 2 189 ? -71.261 1.816   37.625  1.00 63.22  ? 185 PRO F CB  1 
ATOM   2935 C CG  . PRO B 2 189 ? -70.668 2.882   36.757  1.00 57.17  ? 185 PRO F CG  1 
ATOM   2936 C CD  . PRO B 2 189 ? -69.270 2.421   36.484  1.00 61.45  ? 185 PRO F CD  1 
ATOM   2937 N N   . SER B 2 190 ? -72.293 -1.198  36.698  1.00 84.06  ? 186 SER F N   1 
ATOM   2938 C CA  . SER B 2 190 ? -73.180 -2.004  35.868  1.00 83.41  ? 186 SER F CA  1 
ATOM   2939 C C   . SER B 2 190 ? -74.430 -1.252  35.416  1.00 84.55  ? 186 SER F C   1 
ATOM   2940 O O   . SER B 2 190 ? -75.169 -1.762  34.564  1.00 76.82  ? 186 SER F O   1 
ATOM   2941 C CB  . SER B 2 190 ? -73.571 -3.278  36.618  1.00 81.73  ? 186 SER F CB  1 
ATOM   2942 O OG  . SER B 2 190 ? -73.983 -3.000  37.949  1.00 85.80  ? 186 SER F OG  1 
ATOM   2943 N N   . SER B 2 191 ? -74.696 -0.073  35.972  1.00 87.31  ? 187 SER F N   1 
ATOM   2944 C CA  . SER B 2 191 ? -75.855 0.704   35.558  1.00 85.76  ? 187 SER F CA  1 
ATOM   2945 C C   . SER B 2 191 ? -75.602 1.515   34.297  1.00 91.33  ? 187 SER F C   1 
ATOM   2946 O O   . SER B 2 191 ? -76.548 2.098   33.758  1.00 99.07  ? 187 SER F O   1 
ATOM   2947 C CB  . SER B 2 191 ? -76.287 1.638   36.690  1.00 82.74  ? 187 SER F CB  1 
ATOM   2948 O OG  . SER B 2 191 ? -76.529 0.904   37.876  1.00 93.75  ? 187 SER F OG  1 
ATOM   2949 N N   . SER B 2 192 ? -74.366 1.560   33.808  1.00 91.28  ? 188 SER F N   1 
ATOM   2950 C CA  . SER B 2 192 ? -74.009 2.412   32.684  1.00 83.61  ? 188 SER F CA  1 
ATOM   2951 C C   . SER B 2 192 ? -73.916 1.666   31.361  1.00 79.10  ? 188 SER F C   1 
ATOM   2952 O O   . SER B 2 192 ? -73.630 2.291   30.337  1.00 81.11  ? 188 SER F O   1 
ATOM   2953 C CB  . SER B 2 192 ? -72.679 3.116   32.965  1.00 72.55  ? 188 SER F CB  1 
ATOM   2954 O OG  . SER B 2 192 ? -72.765 3.895   34.144  1.00 79.46  ? 188 SER F OG  1 
ATOM   2955 N N   . LEU B 2 193 ? -74.140 0.350   31.352  1.00 79.67  ? 189 LEU F N   1 
ATOM   2956 C CA  . LEU B 2 193 ? -73.984 -0.400  30.109  1.00 95.38  ? 189 LEU F CA  1 
ATOM   2957 C C   . LEU B 2 193 ? -75.015 0.024   29.071  1.00 93.62  ? 189 LEU F C   1 
ATOM   2958 O O   . LEU B 2 193 ? -74.684 0.199   27.893  1.00 97.95  ? 189 LEU F O   1 
ATOM   2959 C CB  . LEU B 2 193 ? -74.080 -1.903  30.371  1.00 91.86  ? 189 LEU F CB  1 
ATOM   2960 C CG  . LEU B 2 193 ? -72.840 -2.598  30.938  1.00 79.49  ? 189 LEU F CG  1 
ATOM   2961 C CD1 . LEU B 2 193 ? -71.572 -2.102  30.261  1.00 79.19  ? 189 LEU F CD1 1 
ATOM   2962 C CD2 . LEU B 2 193 ? -72.760 -2.399  32.429  1.00 84.78  ? 189 LEU F CD2 1 
ATOM   2963 N N   . GLY B 2 194 ? -76.271 0.188   29.489  1.00 91.09  ? 190 GLY F N   1 
ATOM   2964 C CA  . GLY B 2 194 ? -77.309 0.564   28.544  1.00 89.62  ? 190 GLY F CA  1 
ATOM   2965 C C   . GLY B 2 194 ? -77.150 1.976   28.013  1.00 97.47  ? 190 GLY F C   1 
ATOM   2966 O O   . GLY B 2 194 ? -77.354 2.227   26.821  1.00 96.05  ? 190 GLY F O   1 
ATOM   2967 N N   . THR B 2 195 ? -76.775 2.915   28.882  1.00 95.62  ? 191 THR F N   1 
ATOM   2968 C CA  . THR B 2 195 ? -76.748 4.328   28.521  1.00 88.35  ? 191 THR F CA  1 
ATOM   2969 C C   . THR B 2 195 ? -75.393 4.770   27.970  1.00 88.56  ? 191 THR F C   1 
ATOM   2970 O O   . THR B 2 195 ? -75.332 5.420   26.922  1.00 82.28  ? 191 THR F O   1 
ATOM   2971 C CB  . THR B 2 195 ? -77.139 5.184   29.733  1.00 83.02  ? 191 THR F CB  1 
ATOM   2972 O OG1 . THR B 2 195 ? -76.789 6.553   29.491  1.00 91.00  ? 191 THR F OG1 1 
ATOM   2973 C CG2 . THR B 2 195 ? -76.447 4.691   31.001  1.00 76.54  ? 191 THR F CG2 1 
ATOM   2974 N N   . GLN B 2 196 ? -74.305 4.430   28.656  1.00 90.57  ? 192 GLN F N   1 
ATOM   2975 C CA  . GLN B 2 196 ? -72.981 4.877   28.247  1.00 83.96  ? 192 GLN F CA  1 
ATOM   2976 C C   . GLN B 2 196 ? -72.420 3.998   27.136  1.00 81.46  ? 192 GLN F C   1 
ATOM   2977 O O   . GLN B 2 196 ? -72.607 2.778   27.131  1.00 87.37  ? 192 GLN F O   1 
ATOM   2978 C CB  . GLN B 2 196 ? -72.026 4.876   29.442  1.00 77.54  ? 192 GLN F CB  1 
ATOM   2979 C CG  . GLN B 2 196 ? -71.598 6.260   29.902  1.00 78.74  ? 192 GLN F CG  1 
ATOM   2980 C CD  . GLN B 2 196 ? -70.665 6.941   28.917  1.00 78.85  ? 192 GLN F CD  1 
ATOM   2981 O OE1 . GLN B 2 196 ? -70.135 6.308   28.003  1.00 73.35  ? 192 GLN F OE1 1 
ATOM   2982 N NE2 . GLN B 2 196 ? -70.457 8.240   29.101  1.00 86.47  ? 192 GLN F NE2 1 
ATOM   2983 N N   . THR B 2 197 ? -71.723 4.629   26.195  1.00 68.05  ? 193 THR F N   1 
ATOM   2984 C CA  . THR B 2 197 ? -71.055 3.937   25.101  1.00 72.89  ? 193 THR F CA  1 
ATOM   2985 C C   . THR B 2 197 ? -69.556 3.917   25.368  1.00 75.75  ? 193 THR F C   1 
ATOM   2986 O O   . THR B 2 197 ? -68.955 4.964   25.632  1.00 67.48  ? 193 THR F O   1 
ATOM   2987 C CB  . THR B 2 197 ? -71.360 4.609   23.757  1.00 78.24  ? 193 THR F CB  1 
ATOM   2988 O OG1 . THR B 2 197 ? -72.651 4.189   23.293  1.00 94.08  ? 193 THR F OG1 1 
ATOM   2989 C CG2 . THR B 2 197 ? -70.309 4.252   22.713  1.00 70.15  ? 193 THR F CG2 1 
ATOM   2990 N N   . TYR B 2 198 ? -68.963 2.726   25.318  1.00 82.29  ? 194 TYR F N   1 
ATOM   2991 C CA  . TYR B 2 198 ? -67.545 2.533   25.591  1.00 68.01  ? 194 TYR F CA  1 
ATOM   2992 C C   . TYR B 2 198 ? -66.835 2.106   24.314  1.00 67.33  ? 194 TYR F C   1 
ATOM   2993 O O   . TYR B 2 198 ? -67.245 1.140   23.661  1.00 67.10  ? 194 TYR F O   1 
ATOM   2994 C CB  . TYR B 2 198 ? -67.336 1.493   26.694  1.00 67.40  ? 194 TYR F CB  1 
ATOM   2995 C CG  . TYR B 2 198 ? -67.955 1.887   28.017  1.00 63.45  ? 194 TYR F CG  1 
ATOM   2996 C CD1 . TYR B 2 198 ? -67.274 2.707   28.907  1.00 60.19  ? 194 TYR F CD1 1 
ATOM   2997 C CD2 . TYR B 2 198 ? -69.223 1.447   28.371  1.00 58.41  ? 194 TYR F CD2 1 
ATOM   2998 C CE1 . TYR B 2 198 ? -67.838 3.076   30.115  1.00 57.30  ? 194 TYR F CE1 1 
ATOM   2999 C CE2 . TYR B 2 198 ? -69.795 1.808   29.576  1.00 67.89  ? 194 TYR F CE2 1 
ATOM   3000 C CZ  . TYR B 2 198 ? -69.098 2.623   30.445  1.00 65.54  ? 194 TYR F CZ  1 
ATOM   3001 O OH  . TYR B 2 198 ? -69.664 2.986   31.646  1.00 62.39  ? 194 TYR F OH  1 
ATOM   3002 N N   . ILE B 2 199 ? -65.776 2.832   23.963  1.00 63.00  ? 195 ILE F N   1 
ATOM   3003 C CA  . ILE B 2 199 ? -65.002 2.588   22.753  1.00 68.32  ? 195 ILE F CA  1 
ATOM   3004 C C   . ILE B 2 199 ? -63.528 2.555   23.127  1.00 72.61  ? 195 ILE F C   1 
ATOM   3005 O O   . ILE B 2 199 ? -63.039 3.460   23.813  1.00 81.51  ? 195 ILE F O   1 
ATOM   3006 C CB  . ILE B 2 199 ? -65.264 3.668   21.684  1.00 78.13  ? 195 ILE F CB  1 
ATOM   3007 C CG1 . ILE B 2 199 ? -66.735 3.653   21.261  1.00 67.07  ? 195 ILE F CG1 1 
ATOM   3008 C CG2 . ILE B 2 199 ? -64.341 3.482   20.484  1.00 59.53  ? 195 ILE F CG2 1 
ATOM   3009 C CD1 . ILE B 2 199 ? -67.165 4.903   20.533  1.00 57.43  ? 195 ILE F CD1 1 
ATOM   3010 N N   . CYS B 2 200 ? -62.824 1.520   22.677  1.00 69.06  ? 196 CYS F N   1 
ATOM   3011 C CA  . CYS B 2 200 ? -61.391 1.391   22.904  1.00 71.39  ? 196 CYS F CA  1 
ATOM   3012 C C   . CYS B 2 200 ? -60.647 1.831   21.649  1.00 67.60  ? 196 CYS F C   1 
ATOM   3013 O O   . CYS B 2 200 ? -61.010 1.439   20.535  1.00 62.89  ? 196 CYS F O   1 
ATOM   3014 C CB  . CYS B 2 200 ? -61.019 -0.046  23.282  1.00 71.26  ? 196 CYS F CB  1 
ATOM   3015 S SG  . CYS B 2 200 ? -61.314 -1.284  21.998  1.00 93.23  ? 196 CYS F SG  1 
ATOM   3016 N N   . ASN B 2 201 ? -59.625 2.661   21.833  1.00 66.70  ? 197 ASN F N   1 
ATOM   3017 C CA  . ASN B 2 201 ? -58.867 3.246   20.732  1.00 57.46  ? 197 ASN F CA  1 
ATOM   3018 C C   . ASN B 2 201 ? -57.515 2.549   20.664  1.00 52.16  ? 197 ASN F C   1 
ATOM   3019 O O   . ASN B 2 201 ? -56.639 2.797   21.499  1.00 48.65  ? 197 ASN F O   1 
ATOM   3020 C CB  . ASN B 2 201 ? -58.705 4.752   20.926  1.00 67.79  ? 197 ASN F CB  1 
ATOM   3021 C CG  . ASN B 2 201 ? -59.961 5.408   21.470  1.00 73.41  ? 197 ASN F CG  1 
ATOM   3022 O OD1 . ASN B 2 201 ? -59.987 5.872   22.610  1.00 66.90  ? 197 ASN F OD1 1 
ATOM   3023 N ND2 . ASN B 2 201 ? -61.011 5.450   20.656  1.00 70.39  ? 197 ASN F ND2 1 
ATOM   3024 N N   . VAL B 2 202 ? -57.348 1.681   19.674  1.00 52.45  ? 198 VAL F N   1 
ATOM   3025 C CA  . VAL B 2 202 ? -56.122 0.914   19.495  1.00 48.47  ? 198 VAL F CA  1 
ATOM   3026 C C   . VAL B 2 202 ? -55.334 1.534   18.351  1.00 49.84  ? 198 VAL F C   1 
ATOM   3027 O O   . VAL B 2 202 ? -55.873 1.743   17.257  1.00 53.68  ? 198 VAL F O   1 
ATOM   3028 C CB  . VAL B 2 202 ? -56.430 -0.568  19.220  1.00 46.75  ? 198 VAL F CB  1 
ATOM   3029 C CG1 . VAL B 2 202 ? -55.142 -1.351  19.047  1.00 43.32  ? 198 VAL F CG1 1 
ATOM   3030 C CG2 . VAL B 2 202 ? -57.276 -1.155  20.345  1.00 48.16  ? 198 VAL F CG2 1 
ATOM   3031 N N   . ASN B 2 203 ? -54.065 1.844   18.603  1.00 50.71  ? 199 ASN F N   1 
ATOM   3032 C CA  . ASN B 2 203 ? -53.196 2.444   17.600  1.00 50.82  ? 199 ASN F CA  1 
ATOM   3033 C C   . ASN B 2 203 ? -51.901 1.650   17.523  1.00 51.89  ? 199 ASN F C   1 
ATOM   3034 O O   . ASN B 2 203 ? -51.252 1.413   18.547  1.00 51.24  ? 199 ASN F O   1 
ATOM   3035 C CB  . ASN B 2 203 ? -52.912 3.917   17.923  1.00 46.27  ? 199 ASN F CB  1 
ATOM   3036 C CG  . ASN B 2 203 ? -52.131 4.617   16.825  1.00 66.21  ? 199 ASN F CG  1 
ATOM   3037 O OD1 . ASN B 2 203 ? -51.448 5.611   17.073  1.00 70.29  ? 199 ASN F OD1 1 
ATOM   3038 N ND2 . ASN B 2 203 ? -52.225 4.098   15.605  1.00 65.06  ? 199 ASN F ND2 1 
ATOM   3039 N N   . HIS B 2 204 ? -51.532 1.240   16.312  1.00 47.77  ? 200 HIS F N   1 
ATOM   3040 C CA  . HIS B 2 204 ? -50.312 0.477   16.055  1.00 50.51  ? 200 HIS F CA  1 
ATOM   3041 C C   . HIS B 2 204 ? -49.498 1.278   15.043  1.00 62.43  ? 200 HIS F C   1 
ATOM   3042 O O   . HIS B 2 204 ? -49.662 1.118   13.831  1.00 64.49  ? 200 HIS F O   1 
ATOM   3043 C CB  . HIS B 2 204 ? -50.627 -0.939  15.543  1.00 50.33  ? 200 HIS F CB  1 
ATOM   3044 C CG  . HIS B 2 204 ? -49.421 -1.819  15.410  1.00 48.87  ? 200 HIS F CG  1 
ATOM   3045 N ND1 . HIS B 2 204 ? -49.342 -2.841  14.490  1.00 58.38  ? 200 HIS F ND1 1 
ATOM   3046 C CD2 . HIS B 2 204 ? -48.250 -1.835  16.089  1.00 55.38  ? 200 HIS F CD2 1 
ATOM   3047 C CE1 . HIS B 2 204 ? -48.170 -3.443  14.601  1.00 46.57  ? 200 HIS F CE1 1 
ATOM   3048 N NE2 . HIS B 2 204 ? -47.489 -2.852  15.565  1.00 47.83  ? 200 HIS F NE2 1 
ATOM   3049 N N   . LYS B 2 205 ? -48.625 2.145   15.552  1.00 63.09  ? 201 LYS F N   1 
ATOM   3050 C CA  . LYS B 2 205 ? -47.815 2.986   14.674  1.00 52.84  ? 201 LYS F CA  1 
ATOM   3051 C C   . LYS B 2 205 ? -46.951 2.207   13.685  1.00 60.23  ? 201 LYS F C   1 
ATOM   3052 O O   . LYS B 2 205 ? -46.846 2.653   12.529  1.00 69.93  ? 201 LYS F O   1 
ATOM   3053 C CB  . LYS B 2 205 ? -46.955 3.935   15.518  1.00 48.47  ? 201 LYS F CB  1 
ATOM   3054 C CG  . LYS B 2 205 ? -47.734 5.061   16.174  1.00 58.24  ? 201 LYS F CG  1 
ATOM   3055 C CD  . LYS B 2 205 ? -46.787 6.068   16.803  1.00 58.51  ? 201 LYS F CD  1 
ATOM   3056 C CE  . LYS B 2 205 ? -47.398 7.458   16.838  1.00 76.21  ? 201 LYS F CE  1 
ATOM   3057 N NZ  . LYS B 2 205 ? -46.361 8.517   17.001  1.00 80.06  ? 201 LYS F NZ  1 
ATOM   3058 N N   . PRO B 2 206 ? -46.292 1.096   14.047  1.00 49.83  ? 202 PRO F N   1 
ATOM   3059 C CA  . PRO B 2 206 ? -45.514 0.363   13.031  1.00 42.76  ? 202 PRO F CA  1 
ATOM   3060 C C   . PRO B 2 206 ? -46.338 -0.090  11.841  1.00 51.57  ? 202 PRO F C   1 
ATOM   3061 O O   . PRO B 2 206 ? -45.809 -0.170  10.725  1.00 53.67  ? 202 PRO F O   1 
ATOM   3062 C CB  . PRO B 2 206 ? -44.957 -0.832  13.814  1.00 43.93  ? 202 PRO F CB  1 
ATOM   3063 C CG  . PRO B 2 206 ? -44.850 -0.342  15.198  1.00 49.81  ? 202 PRO F CG  1 
ATOM   3064 C CD  . PRO B 2 206 ? -46.023 0.577   15.402  1.00 48.51  ? 202 PRO F CD  1 
ATOM   3065 N N   . SER B 2 207 ? -47.614 -0.404  12.043  1.00 65.89  ? 203 SER F N   1 
ATOM   3066 C CA  . SER B 2 207 ? -48.499 -0.808  10.962  1.00 65.83  ? 203 SER F CA  1 
ATOM   3067 C C   . SER B 2 207 ? -49.393 0.321   10.468  1.00 69.26  ? 203 SER F C   1 
ATOM   3068 O O   . SER B 2 207 ? -50.162 0.111   9.525   1.00 70.20  ? 203 SER F O   1 
ATOM   3069 C CB  . SER B 2 207 ? -49.364 -1.990  11.409  1.00 52.74  ? 203 SER F CB  1 
ATOM   3070 O OG  . SER B 2 207 ? -50.504 -2.131  10.582  1.00 70.09  ? 203 SER F OG  1 
ATOM   3071 N N   . ASN B 2 208 ? -49.300 1.508   11.070  1.00 56.78  ? 204 ASN F N   1 
ATOM   3072 C CA  . ASN B 2 208 ? -50.178 2.631   10.746  1.00 58.77  ? 204 ASN F CA  1 
ATOM   3073 C C   . ASN B 2 208 ? -51.646 2.214   10.850  1.00 65.97  ? 204 ASN F C   1 
ATOM   3074 O O   . ASN B 2 208 ? -52.460 2.464   9.959   1.00 68.99  ? 204 ASN F O   1 
ATOM   3075 C CB  . ASN B 2 208 ? -49.854 3.195   9.361   1.00 60.17  ? 204 ASN F CB  1 
ATOM   3076 C CG  . ASN B 2 208 ? -50.532 4.527   9.099   1.00 75.60  ? 204 ASN F CG  1 
ATOM   3077 O OD1 . ASN B 2 208 ? -50.819 5.284   10.027  1.00 73.79  ? 204 ASN F OD1 1 
ATOM   3078 N ND2 . ASN B 2 208 ? -50.796 4.817   7.830   1.00 64.29  ? 204 ASN F ND2 1 
ATOM   3079 N N   . THR B 2 209 ? -51.976 1.552   11.954  1.00 61.10  ? 205 THR F N   1 
ATOM   3080 C CA  . THR B 2 209 ? -53.306 1.003   12.183  1.00 56.50  ? 205 THR F CA  1 
ATOM   3081 C C   . THR B 2 209 ? -54.045 1.855   13.205  1.00 58.51  ? 205 THR F C   1 
ATOM   3082 O O   . THR B 2 209 ? -53.531 2.104   14.301  1.00 63.08  ? 205 THR F O   1 
ATOM   3083 C CB  . THR B 2 209 ? -53.218 -0.448  12.668  1.00 63.43  ? 205 THR F CB  1 
ATOM   3084 O OG1 . THR B 2 209 ? -52.523 -1.239  11.696  1.00 62.53  ? 205 THR F OG1 1 
ATOM   3085 C CG2 . THR B 2 209 ? -54.609 -1.030  12.893  1.00 56.56  ? 205 THR F CG2 1 
ATOM   3086 N N   . LYS B 2 210 ? -55.243 2.306   12.842  1.00 55.27  ? 206 LYS F N   1 
ATOM   3087 C CA  . LYS B 2 210 ? -56.133 3.017   13.752  1.00 58.31  ? 206 LYS F CA  1 
ATOM   3088 C C   . LYS B 2 210 ? -57.450 2.256   13.814  1.00 62.86  ? 206 LYS F C   1 
ATOM   3089 O O   . LYS B 2 210 ? -58.085 2.029   12.778  1.00 71.83  ? 206 LYS F O   1 
ATOM   3090 C CB  . LYS B 2 210 ? -56.358 4.460   13.291  1.00 56.50  ? 206 LYS F CB  1 
ATOM   3091 C CG  . LYS B 2 210 ? -57.324 5.252   14.165  1.00 72.60  ? 206 LYS F CG  1 
ATOM   3092 C CD  . LYS B 2 210 ? -58.405 5.954   13.340  1.00 77.11  ? 206 LYS F CD  1 
ATOM   3093 C CE  . LYS B 2 210 ? -59.339 4.963   12.647  1.00 70.19  ? 206 LYS F CE  1 
ATOM   3094 N NZ  . LYS B 2 210 ? -60.410 5.638   11.854  1.00 71.16  ? 206 LYS F NZ  1 
ATOM   3095 N N   . VAL B 2 211 ? -57.846 1.842   15.018  1.00 48.31  ? 207 VAL F N   1 
ATOM   3096 C CA  . VAL B 2 211 ? -59.091 1.105   15.226  1.00 46.01  ? 207 VAL F CA  1 
ATOM   3097 C C   . VAL B 2 211 ? -59.796 1.691   16.442  1.00 50.66  ? 207 VAL F C   1 
ATOM   3098 O O   . VAL B 2 211 ? -59.248 1.668   17.550  1.00 60.02  ? 207 VAL F O   1 
ATOM   3099 C CB  . VAL B 2 211 ? -58.866 -0.406  15.430  1.00 37.13  ? 207 VAL F CB  1 
ATOM   3100 C CG1 . VAL B 2 211 ? -60.204 -1.126  15.548  1.00 52.79  ? 207 VAL F CG1 1 
ATOM   3101 C CG2 . VAL B 2 211 ? -58.042 -0.999  14.296  1.00 33.58  ? 207 VAL F CG2 1 
ATOM   3102 N N   . ASP B 2 212 ? -61.002 2.213   16.241  1.00 53.94  ? 208 ASP F N   1 
ATOM   3103 C CA  . ASP B 2 212 ? -61.866 2.655   17.332  1.00 62.80  ? 208 ASP F CA  1 
ATOM   3104 C C   . ASP B 2 212 ? -62.983 1.623   17.468  1.00 74.05  ? 208 ASP F C   1 
ATOM   3105 O O   . ASP B 2 212 ? -64.071 1.772   16.913  1.00 79.11  ? 208 ASP F O   1 
ATOM   3106 C CB  . ASP B 2 212 ? -62.412 4.065   17.074  1.00 55.95  ? 208 ASP F CB  1 
ATOM   3107 C CG  . ASP B 2 212 ? -61.340 5.132   17.182  1.00 74.96  ? 208 ASP F CG  1 
ATOM   3108 O OD1 . ASP B 2 212 ? -60.171 4.774   17.437  1.00 73.09  ? 208 ASP F OD1 1 
ATOM   3109 O OD2 . ASP B 2 212 ? -61.665 6.327   17.018  1.00 95.24  ? 208 ASP F OD2 1 
ATOM   3110 N N   . LYS B 2 213 ? -62.697 0.558   18.212  1.00 76.15  ? 209 LYS F N   1 
ATOM   3111 C CA  . LYS B 2 213 ? -63.652 -0.528  18.377  1.00 70.07  ? 209 LYS F CA  1 
ATOM   3112 C C   . LYS B 2 213 ? -64.633 -0.202  19.495  1.00 61.26  ? 209 LYS F C   1 
ATOM   3113 O O   . LYS B 2 213 ? -64.234 0.229   20.581  1.00 66.11  ? 209 LYS F O   1 
ATOM   3114 C CB  . LYS B 2 213 ? -62.926 -1.839  18.672  1.00 76.24  ? 209 LYS F CB  1 
ATOM   3115 C CG  . LYS B 2 213 ? -63.820 -2.937  19.234  1.00 63.97  ? 209 LYS F CG  1 
ATOM   3116 C CD  . LYS B 2 213 ? -64.870 -3.387  18.231  1.00 56.31  ? 209 LYS F CD  1 
ATOM   3117 C CE  . LYS B 2 213 ? -64.232 -4.010  17.002  1.00 62.51  ? 209 LYS F CE  1 
ATOM   3118 N NZ  . LYS B 2 213 ? -65.248 -4.669  16.138  1.00 66.91  ? 209 LYS F NZ  1 
ATOM   3119 N N   . LYS B 2 214 ? -65.916 -0.410  19.225  1.00 71.42  ? 210 LYS F N   1 
ATOM   3120 C CA  . LYS B 2 214 ? -66.972 -0.203  20.203  1.00 65.60  ? 210 LYS F CA  1 
ATOM   3121 C C   . LYS B 2 214 ? -67.394 -1.549  20.775  1.00 78.42  ? 210 LYS F C   1 
ATOM   3122 O O   . LYS B 2 214 ? -67.608 -2.508  20.025  1.00 81.15  ? 210 LYS F O   1 
ATOM   3123 C CB  . LYS B 2 214 ? -68.169 0.501   19.562  1.00 62.88  ? 210 LYS F CB  1 
ATOM   3124 C CG  . LYS B 2 214 ? -69.424 0.517   20.417  1.00 72.29  ? 210 LYS F CG  1 
ATOM   3125 C CD  . LYS B 2 214 ? -70.661 0.742   19.558  1.00 89.03  ? 210 LYS F CD  1 
ATOM   3126 C CE  . LYS B 2 214 ? -71.938 0.746   20.388  1.00 84.24  ? 210 LYS F CE  1 
ATOM   3127 N NZ  . LYS B 2 214 ? -72.551 2.102   20.482  1.00 70.55  ? 210 LYS F NZ  1 
ATOM   3128 N N   . VAL B 2 215 ? -67.501 -1.622  22.099  1.00 69.57  ? 211 VAL F N   1 
ATOM   3129 C CA  . VAL B 2 215 ? -67.961 -2.826  22.779  1.00 70.60  ? 211 VAL F CA  1 
ATOM   3130 C C   . VAL B 2 215 ? -69.387 -2.597  23.256  1.00 64.68  ? 211 VAL F C   1 
ATOM   3131 O O   . VAL B 2 215 ? -69.773 -1.480  23.619  1.00 74.96  ? 211 VAL F O   1 
ATOM   3132 C CB  . VAL B 2 215 ? -67.041 -3.216  23.955  1.00 63.42  ? 211 VAL F CB  1 
ATOM   3133 C CG1 . VAL B 2 215 ? -65.616 -3.404  23.469  1.00 59.55  ? 211 VAL F CG1 1 
ATOM   3134 C CG2 . VAL B 2 215 ? -67.093 -2.163  25.040  1.00 72.01  ? 211 VAL F CG2 1 
ATOM   3135 N N   . GLU B 2 216 ? -70.178 -3.664  23.243  1.00 71.44  ? 212 GLU F N   1 
ATOM   3136 C CA  . GLU B 2 216 ? -71.580 -3.586  23.614  1.00 65.66  ? 212 GLU F CA  1 
ATOM   3137 C C   . GLU B 2 216 ? -71.918 -4.683  24.609  1.00 75.03  ? 212 GLU F C   1 
ATOM   3138 O O   . GLU B 2 216 ? -71.370 -5.787  24.533  1.00 74.91  ? 212 GLU F O   1 
ATOM   3139 C CB  . GLU B 2 216 ? -72.485 -3.725  22.381  1.00 71.79  ? 212 GLU F CB  1 
ATOM   3140 C CG  . GLU B 2 216 ? -72.171 -2.742  21.263  1.00 93.33  ? 212 GLU F CG  1 
ATOM   3141 C CD  . GLU B 2 216 ? -72.235 -3.376  19.884  1.00 119.81 ? 212 GLU F CD  1 
ATOM   3142 O OE1 . GLU B 2 216 ? -73.029 -4.323  19.690  1.00 127.40 ? 212 GLU F OE1 1 
ATOM   3143 O OE2 . GLU B 2 216 ? -71.482 -2.930  18.993  1.00 115.10 ? 212 GLU F OE2 1 
ATOM   3144 N N   . PRO B 2 217 ? -72.819 -4.410  25.550  1.00 71.77  ? 213 PRO F N   1 
ATOM   3145 C CA  . PRO B 2 217 ? -73.250 -5.460  26.479  1.00 79.38  ? 213 PRO F CA  1 
ATOM   3146 C C   . PRO B 2 217 ? -74.031 -6.555  25.766  1.00 73.50  ? 213 PRO F C   1 
ATOM   3147 O O   . PRO B 2 217 ? -74.675 -6.325  24.740  1.00 69.88  ? 213 PRO F O   1 
ATOM   3148 C CB  . PRO B 2 217 ? -74.133 -4.708  27.481  1.00 74.91  ? 213 PRO F CB  1 
ATOM   3149 C CG  . PRO B 2 217 ? -74.593 -3.493  26.744  1.00 77.93  ? 213 PRO F CG  1 
ATOM   3150 C CD  . PRO B 2 217 ? -73.459 -3.115  25.837  1.00 69.59  ? 213 PRO F CD  1 
ATOM   3151 N N   . LYS B 2 218 ? -73.956 -7.762  26.323  1.00 82.38  ? 214 LYS F N   1 
ATOM   3152 C CA  . LYS B 2 218 ? -74.693 -8.909  25.795  1.00 80.44  ? 214 LYS F CA  1 
ATOM   3153 C C   . LYS B 2 218 ? -75.931 -9.224  26.631  1.00 73.02  ? 214 LYS F C   1 
ATOM   3154 O O   . LYS B 2 218 ? -76.007 -8.873  27.809  1.00 68.38  ? 214 LYS F O   1 
ATOM   3155 C CB  . LYS B 2 218 ? -73.788 -10.143 25.721  1.00 73.56  ? 214 LYS F CB  1 
ATOM   3156 C CG  . LYS B 2 218 ? -73.070 -10.307 24.391  1.00 78.06  ? 214 LYS F CG  1 
ATOM   3157 C CD  . LYS B 2 218 ? -72.096 -11.476 24.419  1.00 81.34  ? 214 LYS F CD  1 
ATOM   3158 C CE  . LYS B 2 218 ? -72.784 -12.778 24.800  1.00 83.49  ? 214 LYS F CE  1 
ATOM   3159 N NZ  . LYS B 2 218 ? -71.822 -13.915 24.834  1.00 69.77  ? 214 LYS F NZ  1 
ATOM   3160 N N   . GLU C 3 1   ? -13.730 -6.223  32.255  1.00 60.54  ? 1   GLU G N   1 
ATOM   3161 C CA  . GLU C 3 1   ? -15.110 -6.383  32.702  1.00 65.62  ? 1   GLU G CA  1 
ATOM   3162 C C   . GLU C 3 1   ? -15.196 -6.574  34.218  1.00 69.06  ? 1   GLU G C   1 
ATOM   3163 O O   . GLU C 3 1   ? -14.433 -7.344  34.802  1.00 73.54  ? 1   GLU G O   1 
ATOM   3164 C CB  . GLU C 3 1   ? -15.768 -7.568  31.985  1.00 83.46  ? 1   GLU G CB  1 
ATOM   3165 C CG  . GLU C 3 1   ? -16.927 -7.193  31.060  1.00 84.95  ? 1   GLU G CG  1 
ATOM   3166 C CD  . GLU C 3 1   ? -18.204 -6.838  31.810  1.00 96.61  ? 1   GLU G CD  1 
ATOM   3167 O OE1 . GLU C 3 1   ? -18.225 -6.948  33.055  1.00 87.04  ? 1   GLU G OE1 1 
ATOM   3168 O OE2 . GLU C 3 1   ? -19.194 -6.452  31.151  1.00 99.08  ? 1   GLU G OE2 1 
ATOM   3169 N N   . ILE C 3 2   ? -16.127 -5.861  34.850  1.00 64.81  ? 2   ILE G N   1 
ATOM   3170 C CA  . ILE C 3 2   ? -16.381 -5.965  36.283  1.00 75.25  ? 2   ILE G CA  1 
ATOM   3171 C C   . ILE C 3 2   ? -17.879 -6.153  36.491  1.00 69.96  ? 2   ILE G C   1 
ATOM   3172 O O   . ILE C 3 2   ? -18.686 -5.420  35.910  1.00 75.44  ? 2   ILE G O   1 
ATOM   3173 C CB  . ILE C 3 2   ? -15.869 -4.727  37.045  1.00 68.18  ? 2   ILE G CB  1 
ATOM   3174 C CG1 . ILE C 3 2   ? -16.481 -4.664  38.445  1.00 70.05  ? 2   ILE G CG1 1 
ATOM   3175 C CG2 . ILE C 3 2   ? -16.164 -3.459  36.267  1.00 74.77  ? 2   ILE G CG2 1 
ATOM   3176 C CD1 . ILE C 3 2   ? -15.940 -3.541  39.290  1.00 59.55  ? 2   ILE G CD1 1 
ATOM   3177 N N   . VAL C 3 3   ? -18.249 -7.132  37.315  1.00 61.68  ? 3   VAL G N   1 
ATOM   3178 C CA  . VAL C 3 3   ? -19.643 -7.526  37.499  1.00 71.15  ? 3   VAL G CA  1 
ATOM   3179 C C   . VAL C 3 3   ? -20.157 -6.956  38.813  1.00 67.64  ? 3   VAL G C   1 
ATOM   3180 O O   . VAL C 3 3   ? -19.517 -7.110  39.861  1.00 74.07  ? 3   VAL G O   1 
ATOM   3181 C CB  . VAL C 3 3   ? -19.797 -9.057  37.464  1.00 58.73  ? 3   VAL G CB  1 
ATOM   3182 C CG1 . VAL C 3 3   ? -21.200 -9.465  37.907  1.00 43.85  ? 3   VAL G CG1 1 
ATOM   3183 C CG2 . VAL C 3 3   ? -19.489 -9.592  36.068  1.00 50.69  ? 3   VAL G CG2 1 
ATOM   3184 N N   . LEU C 3 4   ? -21.313 -6.303  38.759  1.00 61.19  ? 4   LEU G N   1 
ATOM   3185 C CA  . LEU C 3 4   ? -21.981 -5.774  39.939  1.00 57.06  ? 4   LEU G CA  1 
ATOM   3186 C C   . LEU C 3 4   ? -23.182 -6.646  40.274  1.00 65.48  ? 4   LEU G C   1 
ATOM   3187 O O   . LEU C 3 4   ? -24.025 -6.912  39.409  1.00 69.07  ? 4   LEU G O   1 
ATOM   3188 C CB  . LEU C 3 4   ? -22.418 -4.325  39.716  1.00 65.71  ? 4   LEU G CB  1 
ATOM   3189 C CG  . LEU C 3 4   ? -21.362 -3.261  40.011  1.00 60.83  ? 4   LEU G CG  1 
ATOM   3190 C CD1 . LEU C 3 4   ? -21.627 -2.018  39.195  1.00 58.16  ? 4   LEU G CD1 1 
ATOM   3191 C CD2 . LEU C 3 4   ? -21.367 -2.922  41.490  1.00 66.99  ? 4   LEU G CD2 1 
ATOM   3192 N N   . THR C 3 5   ? -23.255 -7.087  41.524  1.00 75.43  ? 5   THR G N   1 
ATOM   3193 C CA  . THR C 3 5   ? -24.347 -7.922  42.005  1.00 65.34  ? 5   THR G CA  1 
ATOM   3194 C C   . THR C 3 5   ? -25.164 -7.151  43.030  1.00 65.51  ? 5   THR G C   1 
ATOM   3195 O O   . THR C 3 5   ? -24.619 -6.673  44.031  1.00 73.81  ? 5   THR G O   1 
ATOM   3196 C CB  . THR C 3 5   ? -23.820 -9.213  42.629  1.00 49.99  ? 5   THR G CB  1 
ATOM   3197 O OG1 . THR C 3 5   ? -23.112 -9.966  41.637  1.00 56.54  ? 5   THR G OG1 1 
ATOM   3198 C CG2 . THR C 3 5   ? -24.980 -10.042 43.164  1.00 55.33  ? 5   THR G CG2 1 
ATOM   3199 N N   . GLN C 3 6   ? -26.462 -7.041  42.787  1.00 61.58  ? 6   GLN G N   1 
ATOM   3200 C CA  . GLN C 3 6   ? -27.361 -6.351  43.696  1.00 62.74  ? 6   GLN G CA  1 
ATOM   3201 C C   . GLN C 3 6   ? -28.130 -7.361  44.535  1.00 68.31  ? 6   GLN G C   1 
ATOM   3202 O O   . GLN C 3 6   ? -28.644 -8.357  44.015  1.00 81.13  ? 6   GLN G O   1 
ATOM   3203 C CB  . GLN C 3 6   ? -28.340 -5.463  42.929  1.00 75.95  ? 6   GLN G CB  1 
ATOM   3204 C CG  . GLN C 3 6   ? -27.668 -4.460  42.008  1.00 70.92  ? 6   GLN G CG  1 
ATOM   3205 C CD  . GLN C 3 6   ? -28.632 -3.426  41.460  1.00 64.07  ? 6   GLN G CD  1 
ATOM   3206 O OE1 . GLN C 3 6   ? -28.575 -3.075  40.282  1.00 67.09  ? 6   GLN G OE1 1 
ATOM   3207 N NE2 . GLN C 3 6   ? -29.515 -2.926  42.317  1.00 45.44  ? 6   GLN G NE2 1 
ATOM   3208 N N   . SER C 3 7   ? -28.207 -7.101  45.838  1.00 72.17  ? 7   SER G N   1 
ATOM   3209 C CA  . SER C 3 7   ? -28.967 -7.943  46.747  1.00 69.31  ? 7   SER G CA  1 
ATOM   3210 C C   . SER C 3 7   ? -29.843 -7.052  47.617  1.00 55.97  ? 7   SER G C   1 
ATOM   3211 O O   . SER C 3 7   ? -29.351 -6.051  48.161  1.00 72.89  ? 7   SER G O   1 
ATOM   3212 C CB  . SER C 3 7   ? -28.031 -8.795  47.613  1.00 78.21  ? 7   SER G CB  1 
ATOM   3213 O OG  . SER C 3 7   ? -27.280 -9.673  46.796  1.00 85.96  ? 7   SER G OG  1 
ATOM   3214 N N   . PRO C 3 8   ? -31.133 -7.373  47.785  1.00 59.83  ? 8   PRO G N   1 
ATOM   3215 C CA  . PRO C 3 8   ? -31.845 -8.544  47.246  1.00 70.57  ? 8   PRO G CA  1 
ATOM   3216 C C   . PRO C 3 8   ? -32.226 -8.354  45.782  1.00 76.83  ? 8   PRO G C   1 
ATOM   3217 O O   . PRO C 3 8   ? -32.157 -7.246  45.252  1.00 83.51  ? 8   PRO G O   1 
ATOM   3218 C CB  . PRO C 3 8   ? -33.084 -8.624  48.142  1.00 63.18  ? 8   PRO G CB  1 
ATOM   3219 C CG  . PRO C 3 8   ? -33.404 -7.121  48.355  1.00 53.61  ? 8   PRO G CG  1 
ATOM   3220 C CD  . PRO C 3 8   ? -32.045 -6.464  48.512  1.00 56.76  ? 8   PRO G CD  1 
ATOM   3221 N N   . GLY C 3 9   ? -32.618 -9.434  45.104  1.00 74.50  ? 9   GLY G N   1 
ATOM   3222 C CA  . GLY C 3 9   ? -33.163 -9.294  43.763  1.00 68.04  ? 9   GLY G CA  1 
ATOM   3223 C C   . GLY C 3 9   ? -34.501 -8.578  43.745  1.00 65.57  ? 9   GLY G C   1 
ATOM   3224 O O   . GLY C 3 9   ? -34.743 -7.718  42.894  1.00 73.18  ? 9   GLY G O   1 
ATOM   3225 N N   . THR C 3 10  ? -35.395 -8.936  44.667  1.00 62.07  ? 10  THR G N   1 
ATOM   3226 C CA  . THR C 3 10  ? -36.686 -8.281  44.825  1.00 74.68  ? 10  THR G CA  1 
ATOM   3227 C C   . THR C 3 10  ? -36.902 -7.998  46.304  1.00 59.66  ? 10  THR G C   1 
ATOM   3228 O O   . THR C 3 10  ? -36.293 -8.628  47.172  1.00 58.29  ? 10  THR G O   1 
ATOM   3229 C CB  . THR C 3 10  ? -37.858 -9.126  44.280  1.00 72.17  ? 10  THR G CB  1 
ATOM   3230 O OG1 . THR C 3 10  ? -38.028 -10.299 45.084  1.00 71.48  ? 10  THR G OG1 1 
ATOM   3231 C CG2 . THR C 3 10  ? -37.617 -9.535  42.828  1.00 62.69  ? 10  THR G CG2 1 
ATOM   3232 N N   . LEU C 3 11  ? -37.766 -7.028  46.586  1.00 53.47  ? 11  LEU G N   1 
ATOM   3233 C CA  . LEU C 3 11  ? -37.988 -6.623  47.965  1.00 58.31  ? 11  LEU G CA  1 
ATOM   3234 C C   . LEU C 3 11  ? -39.336 -5.916  48.055  1.00 65.74  ? 11  LEU G C   1 
ATOM   3235 O O   . LEU C 3 11  ? -39.701 -5.140  47.166  1.00 75.66  ? 11  LEU G O   1 
ATOM   3236 C CB  . LEU C 3 11  ? -36.827 -5.739  48.453  1.00 60.86  ? 11  LEU G CB  1 
ATOM   3237 C CG  . LEU C 3 11  ? -36.769 -5.293  49.917  1.00 73.61  ? 11  LEU G CG  1 
ATOM   3238 C CD1 . LEU C 3 11  ? -35.367 -5.394  50.476  1.00 59.71  ? 11  LEU G CD1 1 
ATOM   3239 C CD2 . LEU C 3 11  ? -37.203 -3.862  49.950  1.00 77.97  ? 11  LEU G CD2 1 
ATOM   3240 N N   . SER C 3 12  ? -40.080 -6.215  49.121  1.00 57.25  ? 12  SER G N   1 
ATOM   3241 C CA  . SER C 3 12  ? -41.452 -5.726  49.278  1.00 73.34  ? 12  SER G CA  1 
ATOM   3242 C C   . SER C 3 12  ? -41.667 -5.309  50.730  1.00 77.66  ? 12  SER G C   1 
ATOM   3243 O O   . SER C 3 12  ? -41.890 -6.160  51.596  1.00 91.37  ? 12  SER G O   1 
ATOM   3244 C CB  . SER C 3 12  ? -42.463 -6.790  48.858  1.00 75.56  ? 12  SER G CB  1 
ATOM   3245 O OG  . SER C 3 12  ? -43.791 -6.402  49.179  1.00 67.98  ? 12  SER G OG  1 
ATOM   3246 N N   . LEU C 3 13  ? -41.624 -4.004  50.990  1.00 77.10  ? 13  LEU G N   1 
ATOM   3247 C CA  . LEU C 3 13  ? -41.831 -3.473  52.327  1.00 71.19  ? 13  LEU G CA  1 
ATOM   3248 C C   . LEU C 3 13  ? -43.042 -2.543  52.360  1.00 71.43  ? 13  LEU G C   1 
ATOM   3249 O O   . LEU C 3 13  ? -43.458 -1.976  51.344  1.00 75.03  ? 13  LEU G O   1 
ATOM   3250 C CB  . LEU C 3 13  ? -40.583 -2.728  52.838  1.00 80.06  ? 13  LEU G CB  1 
ATOM   3251 C CG  . LEU C 3 13  ? -39.205 -3.414  52.899  1.00 76.58  ? 13  LEU G CG  1 
ATOM   3252 C CD1 . LEU C 3 13  ? -38.314 -2.719  53.934  1.00 87.59  ? 13  LEU G CD1 1 
ATOM   3253 C CD2 . LEU C 3 13  ? -39.312 -4.915  53.184  1.00 80.87  ? 13  LEU G CD2 1 
ATOM   3254 N N   . SER C 3 14  ? -43.619 -2.411  53.548  1.00 80.87  ? 14  SER G N   1 
ATOM   3255 C CA  . SER C 3 14  ? -44.747 -1.518  53.741  1.00 84.74  ? 14  SER G CA  1 
ATOM   3256 C C   . SER C 3 14  ? -44.291 -0.062  53.684  1.00 80.93  ? 14  SER G C   1 
ATOM   3257 O O   . SER C 3 14  ? -43.120 0.245   53.925  1.00 79.87  ? 14  SER G O   1 
ATOM   3258 C CB  . SER C 3 14  ? -45.426 -1.808  55.078  1.00 95.64  ? 14  SER G CB  1 
ATOM   3259 O OG  . SER C 3 14  ? -45.855 -3.158  55.152  1.00 102.22 ? 14  SER G OG  1 
ATOM   3260 N N   . PRO C 3 15  ? -45.199 0.852   53.344  1.00 79.99  ? 15  PRO G N   1 
ATOM   3261 C CA  . PRO C 3 15  ? -44.855 2.279   53.360  1.00 80.39  ? 15  PRO G CA  1 
ATOM   3262 C C   . PRO C 3 15  ? -44.453 2.748   54.754  1.00 81.17  ? 15  PRO G C   1 
ATOM   3263 O O   . PRO C 3 15  ? -44.976 2.279   55.767  1.00 97.01  ? 15  PRO G O   1 
ATOM   3264 C CB  . PRO C 3 15  ? -46.148 2.958   52.892  1.00 68.73  ? 15  PRO G CB  1 
ATOM   3265 C CG  . PRO C 3 15  ? -46.859 1.903   52.099  1.00 76.65  ? 15  PRO G CG  1 
ATOM   3266 C CD  . PRO C 3 15  ? -46.534 0.605   52.773  1.00 74.39  ? 15  PRO G CD  1 
ATOM   3267 N N   . GLY C 3 16  ? -43.507 3.687   54.794  1.00 78.67  ? 16  GLY G N   1 
ATOM   3268 C CA  . GLY C 3 16  ? -43.001 4.224   56.041  1.00 64.27  ? 16  GLY G CA  1 
ATOM   3269 C C   . GLY C 3 16  ? -41.819 3.491   56.639  1.00 69.35  ? 16  GLY G C   1 
ATOM   3270 O O   . GLY C 3 16  ? -41.295 3.933   57.669  1.00 85.36  ? 16  GLY G O   1 
ATOM   3271 N N   . GLU C 3 17  ? -41.378 2.391   56.034  1.00 69.78  ? 17  GLU G N   1 
ATOM   3272 C CA  . GLU C 3 17  ? -40.260 1.620   56.556  1.00 75.62  ? 17  GLU G CA  1 
ATOM   3273 C C   . GLU C 3 17  ? -38.958 2.089   55.908  1.00 68.92  ? 17  GLU G C   1 
ATOM   3274 O O   . GLU C 3 17  ? -38.924 3.069   55.159  1.00 74.25  ? 17  GLU G O   1 
ATOM   3275 C CB  . GLU C 3 17  ? -40.497 0.127   56.331  1.00 85.78  ? 17  GLU G CB  1 
ATOM   3276 C CG  . GLU C 3 17  ? -41.748 -0.419  57.004  1.00 88.83  ? 17  GLU G CG  1 
ATOM   3277 C CD  . GLU C 3 17  ? -41.877 -1.923  56.856  1.00 103.02 ? 17  GLU G CD  1 
ATOM   3278 O OE1 . GLU C 3 17  ? -40.924 -2.555  56.353  1.00 100.30 ? 17  GLU G OE1 1 
ATOM   3279 O OE2 . GLU C 3 17  ? -42.929 -2.475  57.242  1.00 109.21 ? 17  GLU G OE2 1 
ATOM   3280 N N   . ARG C 3 18  ? -37.867 1.390   56.203  1.00 58.72  ? 18  ARG G N   1 
ATOM   3281 C CA  . ARG C 3 18  ? -36.564 1.660   55.611  1.00 70.35  ? 18  ARG G CA  1 
ATOM   3282 C C   . ARG C 3 18  ? -36.190 0.509   54.691  1.00 77.87  ? 18  ARG G C   1 
ATOM   3283 O O   . ARG C 3 18  ? -36.178 -0.651  55.116  1.00 75.40  ? 18  ARG G O   1 
ATOM   3284 C CB  . ARG C 3 18  ? -35.491 1.844   56.687  1.00 74.37  ? 18  ARG G CB  1 
ATOM   3285 C CG  . ARG C 3 18  ? -35.185 3.291   57.033  1.00 69.27  ? 18  ARG G CG  1 
ATOM   3286 C CD  . ARG C 3 18  ? -34.228 3.376   58.212  1.00 66.78  ? 18  ARG G CD  1 
ATOM   3287 N NE  . ARG C 3 18  ? -32.965 2.698   57.948  1.00 84.63  ? 18  ARG G NE  1 
ATOM   3288 C CZ  . ARG C 3 18  ? -31.775 3.282   57.998  1.00 91.32  ? 18  ARG G CZ  1 
ATOM   3289 N NH1 . ARG C 3 18  ? -31.644 4.559   58.318  1.00 89.90  ? 18  ARG G NH1 1 
ATOM   3290 N NH2 . ARG C 3 18  ? -30.687 2.563   57.732  1.00 84.70  ? 18  ARG G NH2 1 
ATOM   3291 N N   . ALA C 3 19  ? -35.887 0.830   53.439  1.00 72.81  ? 19  ALA G N   1 
ATOM   3292 C CA  . ALA C 3 19  ? -35.484 -0.161  52.452  1.00 68.12  ? 19  ALA G CA  1 
ATOM   3293 C C   . ALA C 3 19  ? -33.972 -0.100  52.287  1.00 56.91  ? 19  ALA G C   1 
ATOM   3294 O O   . ALA C 3 19  ? -33.421 0.957   51.964  1.00 66.07  ? 19  ALA G O   1 
ATOM   3295 C CB  . ALA C 3 19  ? -36.186 0.080   51.116  1.00 75.72  ? 19  ALA G CB  1 
ATOM   3296 N N   . THR C 3 20  ? -33.307 -1.226  52.514  1.00 51.98  ? 20  THR G N   1 
ATOM   3297 C CA  . THR C 3 20  ? -31.857 -1.315  52.425  1.00 47.32  ? 20  THR G CA  1 
ATOM   3298 C C   . THR C 3 20  ? -31.494 -2.184  51.232  1.00 59.67  ? 20  THR G C   1 
ATOM   3299 O O   . THR C 3 20  ? -31.901 -3.349  51.160  1.00 69.06  ? 20  THR G O   1 
ATOM   3300 C CB  . THR C 3 20  ? -31.264 -1.883  53.712  1.00 62.58  ? 20  THR G CB  1 
ATOM   3301 O OG1 . THR C 3 20  ? -31.636 -1.047  54.814  1.00 66.40  ? 20  THR G OG1 1 
ATOM   3302 C CG2 . THR C 3 20  ? -29.748 -1.946  53.613  1.00 54.26  ? 20  THR G CG2 1 
ATOM   3303 N N   . LEU C 3 21  ? -30.736 -1.615  50.301  1.00 56.18  ? 21  LEU G N   1 
ATOM   3304 C CA  . LEU C 3 21  ? -30.344 -2.296  49.077  1.00 51.62  ? 21  LEU G CA  1 
ATOM   3305 C C   . LEU C 3 21  ? -28.829 -2.375  49.024  1.00 49.14  ? 21  LEU G C   1 
ATOM   3306 O O   . LEU C 3 21  ? -28.143 -1.359  49.184  1.00 62.68  ? 21  LEU G O   1 
ATOM   3307 C CB  . LEU C 3 21  ? -30.878 -1.574  47.835  1.00 68.52  ? 21  LEU G CB  1 
ATOM   3308 C CG  . LEU C 3 21  ? -32.362 -1.672  47.459  1.00 61.76  ? 21  LEU G CG  1 
ATOM   3309 C CD1 . LEU C 3 21  ? -33.259 -0.943  48.451  1.00 46.87  ? 21  LEU G CD1 1 
ATOM   3310 C CD2 . LEU C 3 21  ? -32.573 -1.131  46.052  1.00 57.82  ? 21  LEU G CD2 1 
ATOM   3311 N N   . SER C 3 22  ? -28.311 -3.574  48.806  1.00 52.28  ? 22  SER G N   1 
ATOM   3312 C CA  . SER C 3 22  ? -26.877 -3.780  48.710  1.00 64.63  ? 22  SER G CA  1 
ATOM   3313 C C   . SER C 3 22  ? -26.453 -3.803  47.247  1.00 69.06  ? 22  SER G C   1 
ATOM   3314 O O   . SER C 3 22  ? -27.262 -4.009  46.339  1.00 68.19  ? 22  SER G O   1 
ATOM   3315 C CB  . SER C 3 22  ? -26.455 -5.076  49.412  1.00 69.63  ? 22  SER G CB  1 
ATOM   3316 O OG  . SER C 3 22  ? -26.282 -6.143  48.494  1.00 80.26  ? 22  SER G OG  1 
ATOM   3317 N N   . CYS C 3 23  ? -25.161 -3.567  47.028  1.00 68.03  ? 23  CYS G N   1 
ATOM   3318 C CA  . CYS C 3 23  ? -24.622 -3.521  45.672  1.00 66.15  ? 23  CYS G CA  1 
ATOM   3319 C C   . CYS C 3 23  ? -23.131 -3.842  45.778  1.00 68.66  ? 23  CYS G C   1 
ATOM   3320 O O   . CYS C 3 23  ? -22.346 -2.993  46.210  1.00 77.26  ? 23  CYS G O   1 
ATOM   3321 C CB  . CYS C 3 23  ? -24.871 -2.163  45.027  1.00 79.42  ? 23  CYS G CB  1 
ATOM   3322 S SG  . CYS C 3 23  ? -24.026 -1.888  43.428  1.00 97.89  ? 23  CYS G SG  1 
ATOM   3323 N N   . ARG C 3 24  ? -22.763 -5.064  45.400  1.00 58.66  ? 24  ARG G N   1 
ATOM   3324 C CA  . ARG C 3 24  ? -21.397 -5.557  45.523  1.00 61.05  ? 24  ARG G CA  1 
ATOM   3325 C C   . ARG C 3 24  ? -20.754 -5.684  44.149  1.00 58.02  ? 24  ARG G C   1 
ATOM   3326 O O   . ARG C 3 24  ? -21.421 -6.032  43.170  1.00 67.85  ? 24  ARG G O   1 
ATOM   3327 C CB  . ARG C 3 24  ? -21.359 -6.909  46.241  1.00 75.29  ? 24  ARG G CB  1 
ATOM   3328 C CG  . ARG C 3 24  ? -21.725 -6.834  47.712  1.00 74.68  ? 24  ARG G CG  1 
ATOM   3329 C CD  . ARG C 3 24  ? -21.796 -8.215  48.338  1.00 80.25  ? 24  ARG G CD  1 
ATOM   3330 N NE  . ARG C 3 24  ? -21.950 -8.148  49.786  1.00 95.89  ? 24  ARG G NE  1 
ATOM   3331 C CZ  . ARG C 3 24  ? -23.110 -8.004  50.412  1.00 106.18 ? 24  ARG G CZ  1 
ATOM   3332 N NH1 . ARG C 3 24  ? -24.248 -7.900  49.745  1.00 85.87  ? 24  ARG G NH1 1 
ATOM   3333 N NH2 . ARG C 3 24  ? -23.129 -7.961  51.742  1.00 109.79 ? 24  ARG G NH2 1 
ATOM   3334 N N   . ALA C 3 25  ? -19.453 -5.410  44.085  1.00 52.23  ? 25  ALA G N   1 
ATOM   3335 C CA  . ALA C 3 25  ? -18.723 -5.355  42.829  1.00 62.29  ? 25  ALA G CA  1 
ATOM   3336 C C   . ALA C 3 25  ? -17.599 -6.383  42.808  1.00 55.88  ? 25  ALA G C   1 
ATOM   3337 O O   . ALA C 3 25  ? -17.112 -6.829  43.851  1.00 54.34  ? 25  ALA G O   1 
ATOM   3338 C CB  . ALA C 3 25  ? -18.142 -3.955  42.583  1.00 80.34  ? 25  ALA G CB  1 
ATOM   3339 N N   . SER C 3 26  ? -17.193 -6.750  41.590  1.00 59.57  ? 26  SER G N   1 
ATOM   3340 C CA  . SER C 3 26  ? -16.089 -7.689  41.408  1.00 52.65  ? 26  SER G CA  1 
ATOM   3341 C C   . SER C 3 26  ? -14.799 -7.138  42.003  1.00 73.21  ? 26  SER G C   1 
ATOM   3342 O O   . SER C 3 26  ? -14.235 -7.710  42.942  1.00 78.32  ? 26  SER G O   1 
ATOM   3343 C CB  . SER C 3 26  ? -15.910 -7.996  39.920  1.00 44.77  ? 26  SER G CB  1 
ATOM   3344 O OG  . SER C 3 26  ? -14.792 -8.838  39.706  1.00 69.69  ? 26  SER G OG  1 
ATOM   3345 N N   . GLN C 3 27  ? -14.314 -6.028  41.459  1.00 76.77  ? 27  GLN G N   1 
ATOM   3346 C CA  . GLN C 3 27  ? -13.169 -5.321  42.008  1.00 65.18  ? 27  GLN G CA  1 
ATOM   3347 C C   . GLN C 3 27  ? -13.635 -4.106  42.803  1.00 71.49  ? 27  GLN G C   1 
ATOM   3348 O O   . GLN C 3 27  ? -14.805 -3.718  42.772  1.00 78.09  ? 27  GLN G O   1 
ATOM   3349 C CB  . GLN C 3 27  ? -12.206 -4.894  40.896  1.00 51.26  ? 27  GLN G CB  1 
ATOM   3350 C CG  . GLN C 3 27  ? -11.136 -5.922  40.575  1.00 60.99  ? 27  GLN G CG  1 
ATOM   3351 C CD  . GLN C 3 27  ? -11.435 -6.709  39.317  1.00 77.26  ? 27  GLN G CD  1 
ATOM   3352 O OE1 . GLN C 3 27  ? -11.402 -6.170  38.211  1.00 75.50  ? 27  GLN G OE1 1 
ATOM   3353 N NE2 . GLN C 3 27  ? -11.726 -7.995  39.478  1.00 88.35  ? 27  GLN G NE2 1 
ATOM   3354 N N   . SER C 3 28  ? -12.696 -3.508  43.530  1.00 77.40  ? 28  SER G N   1 
ATOM   3355 C CA  . SER C 3 28  ? -12.980 -2.287  44.268  1.00 77.78  ? 28  SER G CA  1 
ATOM   3356 C C   . SER C 3 28  ? -12.927 -1.095  43.324  1.00 78.28  ? 28  SER G C   1 
ATOM   3357 O O   . SER C 3 28  ? -11.956 -0.920  42.580  1.00 73.30  ? 28  SER G O   1 
ATOM   3358 C CB  . SER C 3 28  ? -11.991 -2.113  45.419  1.00 74.54  ? 28  SER G CB  1 
ATOM   3359 O OG  . SER C 3 28  ? -10.692 -2.532  45.038  1.00 83.02  ? 28  SER G OG  1 
ATOM   3360 N N   . VAL C 3 29  ? -13.982 -0.276  43.354  1.00 69.56  ? 29  VAL G N   1 
ATOM   3361 C CA  . VAL C 3 29  ? -14.096 0.880   42.471  1.00 72.71  ? 29  VAL G CA  1 
ATOM   3362 C C   . VAL C 3 29  ? -13.829 2.191   43.191  1.00 70.15  ? 29  VAL G C   1 
ATOM   3363 O O   . VAL C 3 29  ? -13.806 3.247   42.544  1.00 88.21  ? 29  VAL G O   1 
ATOM   3364 C CB  . VAL C 3 29  ? -15.482 0.918   41.795  1.00 67.41  ? 29  VAL G CB  1 
ATOM   3365 C CG1 . VAL C 3 29  ? -15.712 -0.354  41.005  1.00 63.87  ? 29  VAL G CG1 1 
ATOM   3366 C CG2 . VAL C 3 29  ? -16.575 1.116   42.830  1.00 54.27  ? 29  VAL G CG2 1 
ATOM   3367 N N   . SER C 3 30  ? -13.634 2.158   44.510  1.00 63.01  ? 30  SER G N   1 
ATOM   3368 C CA  . SER C 3 30  ? -13.279 3.340   45.295  1.00 69.33  ? 30  SER G CA  1 
ATOM   3369 C C   . SER C 3 30  ? -14.355 4.423   45.186  1.00 72.02  ? 30  SER G C   1 
ATOM   3370 O O   . SER C 3 30  ? -14.104 5.548   44.751  1.00 84.70  ? 30  SER G O   1 
ATOM   3371 C CB  . SER C 3 30  ? -11.907 3.881   44.873  1.00 58.50  ? 30  SER G CB  1 
ATOM   3372 O OG  . SER C 3 30  ? -11.533 4.995   45.662  1.00 69.15  ? 30  SER G OG  1 
ATOM   3373 N N   . SER C 3 31  ? -15.573 4.051   45.579  1.00 59.98  ? 31  SER G N   1 
ATOM   3374 C CA  . SER C 3 31  ? -16.711 4.967   45.683  1.00 80.21  ? 31  SER G CA  1 
ATOM   3375 C C   . SER C 3 31  ? -17.130 5.560   44.334  1.00 73.24  ? 31  SER G C   1 
ATOM   3376 O O   . SER C 3 31  ? -17.876 6.547   44.294  1.00 60.82  ? 31  SER G O   1 
ATOM   3377 C CB  . SER C 3 31  ? -16.427 6.095   46.689  1.00 67.98  ? 31  SER G CB  1 
ATOM   3378 O OG  . SER C 3 31  ? -15.440 6.993   46.208  1.00 62.74  ? 31  SER G OG  1 
ATOM   3379 N N   . TYR C 3 32  ? -16.687 4.970   43.222  1.00 63.94  ? 32  TYR G N   1 
ATOM   3380 C CA  . TYR C 3 32  ? -17.087 5.425   41.886  1.00 51.85  ? 32  TYR G CA  1 
ATOM   3381 C C   . TYR C 3 32  ? -18.349 4.689   41.424  1.00 64.49  ? 32  TYR G C   1 
ATOM   3382 O O   . TYR C 3 32  ? -18.373 3.999   40.405  1.00 59.10  ? 32  TYR G O   1 
ATOM   3383 C CB  . TYR C 3 32  ? -15.945 5.235   40.892  1.00 50.00  ? 32  TYR G CB  1 
ATOM   3384 C CG  . TYR C 3 32  ? -14.744 6.118   41.148  1.00 61.91  ? 32  TYR G CG  1 
ATOM   3385 C CD1 . TYR C 3 32  ? -14.842 7.237   41.962  1.00 57.42  ? 32  TYR G CD1 1 
ATOM   3386 C CD2 . TYR C 3 32  ? -13.511 5.833   40.571  1.00 59.67  ? 32  TYR G CD2 1 
ATOM   3387 C CE1 . TYR C 3 32  ? -13.748 8.046   42.201  1.00 58.12  ? 32  TYR G CE1 1 
ATOM   3388 C CE2 . TYR C 3 32  ? -12.411 6.637   40.804  1.00 59.63  ? 32  TYR G CE2 1 
ATOM   3389 C CZ  . TYR C 3 32  ? -12.536 7.742   41.620  1.00 63.25  ? 32  TYR G CZ  1 
ATOM   3390 O OH  . TYR C 3 32  ? -11.448 8.550   41.860  1.00 66.90  ? 32  TYR G OH  1 
ATOM   3391 N N   . LEU C 3 33  ? -19.416 4.862   42.199  1.00 55.04  ? 33  LEU G N   1 
ATOM   3392 C CA  . LEU C 3 33  ? -20.682 4.192   41.953  1.00 52.79  ? 33  LEU G CA  1 
ATOM   3393 C C   . LEU C 3 33  ? -21.796 5.219   41.807  1.00 55.35  ? 33  LEU G C   1 
ATOM   3394 O O   . LEU C 3 33  ? -21.712 6.331   42.332  1.00 60.23  ? 33  LEU G O   1 
ATOM   3395 C CB  . LEU C 3 33  ? -21.020 3.214   43.086  1.00 54.71  ? 33  LEU G CB  1 
ATOM   3396 C CG  . LEU C 3 33  ? -22.113 2.192   42.771  1.00 52.70  ? 33  LEU G CG  1 
ATOM   3397 C CD1 . LEU C 3 33  ? -21.533 0.983   42.049  1.00 45.75  ? 33  LEU G CD1 1 
ATOM   3398 C CD2 . LEU C 3 33  ? -22.856 1.783   44.030  1.00 53.21  ? 33  LEU G CD2 1 
ATOM   3399 N N   . ALA C 3 34  ? -22.846 4.837   41.082  1.00 53.14  ? 34  ALA G N   1 
ATOM   3400 C CA  . ALA C 3 34  ? -24.026 5.675   40.924  1.00 52.33  ? 34  ALA G CA  1 
ATOM   3401 C C   . ALA C 3 34  ? -25.275 4.822   41.095  1.00 54.06  ? 34  ALA G C   1 
ATOM   3402 O O   . ALA C 3 34  ? -25.276 3.629   40.780  1.00 51.50  ? 34  ALA G O   1 
ATOM   3403 C CB  . ALA C 3 34  ? -24.046 6.377   39.558  1.00 50.87  ? 34  ALA G CB  1 
ATOM   3404 N N   . TRP C 3 35  ? -26.338 5.445   41.602  1.00 43.58  ? 35  TRP G N   1 
ATOM   3405 C CA  . TRP C 3 35  ? -27.617 4.785   41.835  1.00 43.56  ? 35  TRP G CA  1 
ATOM   3406 C C   . TRP C 3 35  ? -28.695 5.429   40.976  1.00 43.36  ? 35  TRP G C   1 
ATOM   3407 O O   . TRP C 3 35  ? -28.819 6.658   40.947  1.00 51.88  ? 35  TRP G O   1 
ATOM   3408 C CB  . TRP C 3 35  ? -28.017 4.850   43.313  1.00 55.72  ? 35  TRP G CB  1 
ATOM   3409 C CG  . TRP C 3 35  ? -27.310 3.846   44.172  1.00 69.06  ? 35  TRP G CG  1 
ATOM   3410 C CD1 . TRP C 3 35  ? -26.176 4.047   44.903  1.00 63.55  ? 35  TRP G CD1 1 
ATOM   3411 C CD2 . TRP C 3 35  ? -27.689 2.480   44.388  1.00 71.29  ? 35  TRP G CD2 1 
ATOM   3412 N NE1 . TRP C 3 35  ? -25.826 2.894   45.560  1.00 57.43  ? 35  TRP G NE1 1 
ATOM   3413 C CE2 . TRP C 3 35  ? -26.738 1.917   45.261  1.00 71.19  ? 35  TRP G CE2 1 
ATOM   3414 C CE3 . TRP C 3 35  ? -28.738 1.678   43.927  1.00 66.15  ? 35  TRP G CE3 1 
ATOM   3415 C CZ2 . TRP C 3 35  ? -26.805 0.592   45.685  1.00 63.16  ? 35  TRP G CZ2 1 
ATOM   3416 C CZ3 . TRP C 3 35  ? -28.803 0.361   44.350  1.00 72.72  ? 35  TRP G CZ3 1 
ATOM   3417 C CH2 . TRP C 3 35  ? -27.842 -0.168  45.218  1.00 66.82  ? 35  TRP G CH2 1 
ATOM   3418 N N   . TYR C 3 36  ? -29.481 4.592   40.296  1.00 50.76  ? 36  TYR G N   1 
ATOM   3419 C CA  . TYR C 3 36  ? -30.541 5.033   39.400  1.00 41.11  ? 36  TYR G CA  1 
ATOM   3420 C C   . TYR C 3 36  ? -31.858 4.376   39.792  1.00 40.41  ? 36  TYR G C   1 
ATOM   3421 O O   . TYR C 3 36  ? -31.881 3.270   40.338  1.00 48.87  ? 36  TYR G O   1 
ATOM   3422 C CB  . TYR C 3 36  ? -30.220 4.691   37.938  1.00 48.72  ? 36  TYR G CB  1 
ATOM   3423 C CG  . TYR C 3 36  ? -28.907 5.251   37.442  1.00 41.79  ? 36  TYR G CG  1 
ATOM   3424 C CD1 . TYR C 3 36  ? -28.837 6.525   36.894  1.00 36.23  ? 36  TYR G CD1 1 
ATOM   3425 C CD2 . TYR C 3 36  ? -27.741 4.504   37.517  1.00 42.04  ? 36  TYR G CD2 1 
ATOM   3426 C CE1 . TYR C 3 36  ? -27.644 7.038   36.441  1.00 42.41  ? 36  TYR G CE1 1 
ATOM   3427 C CE2 . TYR C 3 36  ? -26.542 5.009   37.065  1.00 46.46  ? 36  TYR G CE2 1 
ATOM   3428 C CZ  . TYR C 3 36  ? -26.499 6.275   36.529  1.00 42.68  ? 36  TYR G CZ  1 
ATOM   3429 O OH  . TYR C 3 36  ? -25.302 6.776   36.079  1.00 51.99  ? 36  TYR G OH  1 
ATOM   3430 N N   . GLN C 3 37  ? -32.957 5.072   39.507  1.00 45.00  ? 37  GLN G N   1 
ATOM   3431 C CA  . GLN C 3 37  ? -34.304 4.577   39.772  1.00 41.32  ? 37  GLN G CA  1 
ATOM   3432 C C   . GLN C 3 37  ? -35.121 4.638   38.493  1.00 43.61  ? 37  GLN G C   1 
ATOM   3433 O O   . GLN C 3 37  ? -35.219 5.699   37.868  1.00 52.16  ? 37  GLN G O   1 
ATOM   3434 C CB  . GLN C 3 37  ? -34.996 5.394   40.865  1.00 38.76  ? 37  GLN G CB  1 
ATOM   3435 C CG  . GLN C 3 37  ? -36.474 5.075   41.020  1.00 39.67  ? 37  GLN G CG  1 
ATOM   3436 C CD  . GLN C 3 37  ? -37.251 6.204   41.665  1.00 47.47  ? 37  GLN G CD  1 
ATOM   3437 O OE1 . GLN C 3 37  ? -38.396 6.467   41.304  1.00 67.43  ? 37  GLN G OE1 1 
ATOM   3438 N NE2 . GLN C 3 37  ? -36.632 6.878   42.626  1.00 70.96  ? 37  GLN G NE2 1 
ATOM   3439 N N   . GLN C 3 38  ? -35.717 3.512   38.112  1.00 47.69  ? 38  GLN G N   1 
ATOM   3440 C CA  . GLN C 3 38  ? -36.487 3.421   36.876  1.00 47.80  ? 38  GLN G CA  1 
ATOM   3441 C C   . GLN C 3 38  ? -37.900 2.968   37.213  1.00 48.46  ? 38  GLN G C   1 
ATOM   3442 O O   . GLN C 3 38  ? -38.116 1.802   37.564  1.00 63.78  ? 38  GLN G O   1 
ATOM   3443 C CB  . GLN C 3 38  ? -35.828 2.465   35.881  1.00 45.99  ? 38  GLN G CB  1 
ATOM   3444 C CG  . GLN C 3 38  ? -36.541 2.390   34.525  1.00 49.88  ? 38  GLN G CG  1 
ATOM   3445 C CD  . GLN C 3 38  ? -35.833 1.494   33.507  1.00 52.79  ? 38  GLN G CD  1 
ATOM   3446 O OE1 . GLN C 3 38  ? -35.201 0.498   33.865  1.00 52.99  ? 38  GLN G OE1 1 
ATOM   3447 N NE2 . GLN C 3 38  ? -35.936 1.855   32.229  1.00 44.06  ? 38  GLN G NE2 1 
ATOM   3448 N N   . LYS C 3 39  ? -38.850 3.888   37.112  1.00 49.01  ? 39  LYS G N   1 
ATOM   3449 C CA  . LYS C 3 39  ? -40.258 3.568   37.258  1.00 49.17  ? 39  LYS G CA  1 
ATOM   3450 C C   . LYS C 3 39  ? -40.766 2.927   35.973  1.00 56.26  ? 39  LYS G C   1 
ATOM   3451 O O   . LYS C 3 39  ? -40.172 3.118   34.908  1.00 58.18  ? 39  LYS G O   1 
ATOM   3452 C CB  . LYS C 3 39  ? -41.043 4.828   37.601  1.00 45.64  ? 39  LYS G CB  1 
ATOM   3453 C CG  . LYS C 3 39  ? -40.607 5.440   38.926  1.00 54.24  ? 39  LYS G CG  1 
ATOM   3454 C CD  . LYS C 3 39  ? -41.685 6.316   39.555  1.00 64.17  ? 39  LYS G CD  1 
ATOM   3455 C CE  . LYS C 3 39  ? -41.472 7.797   39.245  1.00 84.93  ? 39  LYS G CE  1 
ATOM   3456 N NZ  . LYS C 3 39  ? -42.699 8.620   39.483  1.00 91.45  ? 39  LYS G NZ  1 
ATOM   3457 N N   . PRO C 3 40  ? -41.845 2.140   36.048  1.00 65.70  ? 40  PRO G N   1 
ATOM   3458 C CA  . PRO C 3 40  ? -42.309 1.420   34.857  1.00 68.14  ? 40  PRO G CA  1 
ATOM   3459 C C   . PRO C 3 40  ? -42.685 2.368   33.729  1.00 71.96  ? 40  PRO G C   1 
ATOM   3460 O O   . PRO C 3 40  ? -43.311 3.411   33.944  1.00 57.22  ? 40  PRO G O   1 
ATOM   3461 C CB  . PRO C 3 40  ? -43.530 0.642   35.365  1.00 58.69  ? 40  PRO G CB  1 
ATOM   3462 C CG  . PRO C 3 40  ? -43.989 1.398   36.539  1.00 59.40  ? 40  PRO G CG  1 
ATOM   3463 C CD  . PRO C 3 40  ? -42.728 1.882   37.198  1.00 69.56  ? 40  PRO G CD  1 
ATOM   3464 N N   . GLY C 3 41  ? -42.293 1.975   32.516  1.00 65.08  ? 41  GLY G N   1 
ATOM   3465 C CA  . GLY C 3 41  ? -42.546 2.759   31.327  1.00 53.66  ? 41  GLY G CA  1 
ATOM   3466 C C   . GLY C 3 41  ? -41.862 4.101   31.312  1.00 67.55  ? 41  GLY G C   1 
ATOM   3467 O O   . GLY C 3 41  ? -42.304 5.006   30.601  1.00 75.02  ? 41  GLY G O   1 
ATOM   3468 N N   . GLN C 3 42  ? -40.801 4.263   32.098  1.00 59.51  ? 42  GLN G N   1 
ATOM   3469 C CA  . GLN C 3 42  ? -40.084 5.522   32.197  1.00 47.99  ? 42  GLN G CA  1 
ATOM   3470 C C   . GLN C 3 42  ? -38.590 5.254   32.153  1.00 61.03  ? 42  GLN G C   1 
ATOM   3471 O O   . GLN C 3 42  ? -38.127 4.131   32.371  1.00 59.04  ? 42  GLN G O   1 
ATOM   3472 C CB  . GLN C 3 42  ? -40.435 6.288   33.479  1.00 40.63  ? 42  GLN G CB  1 
ATOM   3473 C CG  . GLN C 3 42  ? -41.864 6.787   33.533  1.00 55.76  ? 42  GLN G CG  1 
ATOM   3474 C CD  . GLN C 3 42  ? -42.176 7.528   34.816  1.00 64.15  ? 42  GLN G CD  1 
ATOM   3475 O OE1 . GLN C 3 42  ? -41.284 8.061   35.475  1.00 64.55  ? 42  GLN G OE1 1 
ATOM   3476 N NE2 . GLN C 3 42  ? -43.452 7.561   35.181  1.00 90.23  ? 42  GLN G NE2 1 
ATOM   3477 N N   . ALA C 3 43  ? -37.842 6.308   31.861  1.00 56.23  ? 43  ALA G N   1 
ATOM   3478 C CA  . ALA C 3 43  ? -36.395 6.235   31.800  1.00 51.13  ? 43  ALA G CA  1 
ATOM   3479 C C   . ALA C 3 43  ? -35.793 6.208   33.200  1.00 51.25  ? 43  ALA G C   1 
ATOM   3480 O O   . ALA C 3 43  ? -36.415 6.661   34.165  1.00 60.42  ? 43  ALA G O   1 
ATOM   3481 C CB  . ALA C 3 43  ? -35.849 7.425   31.023  1.00 50.40  ? 43  ALA G CB  1 
ATOM   3482 N N   . PRO C 3 44  ? -34.583 5.668   33.340  1.00 45.06  ? 44  PRO G N   1 
ATOM   3483 C CA  . PRO C 3 44  ? -33.891 5.750   34.631  1.00 44.82  ? 44  PRO G CA  1 
ATOM   3484 C C   . PRO C 3 44  ? -33.644 7.196   35.035  1.00 49.27  ? 44  PRO G C   1 
ATOM   3485 O O   . PRO C 3 44  ? -33.388 8.063   34.195  1.00 46.93  ? 44  PRO G O   1 
ATOM   3486 C CB  . PRO C 3 44  ? -32.578 5.003   34.376  1.00 41.06  ? 44  PRO G CB  1 
ATOM   3487 C CG  . PRO C 3 44  ? -32.884 4.085   33.241  1.00 42.78  ? 44  PRO G CG  1 
ATOM   3488 C CD  . PRO C 3 44  ? -33.849 4.834   32.373  1.00 45.07  ? 44  PRO G CD  1 
ATOM   3489 N N   . ARG C 3 45  ? -33.731 7.450   36.338  1.00 53.02  ? 45  ARG G N   1 
ATOM   3490 C CA  . ARG C 3 45  ? -33.486 8.764   36.918  1.00 49.10  ? 45  ARG G CA  1 
ATOM   3491 C C   . ARG C 3 45  ? -32.302 8.663   37.869  1.00 54.42  ? 45  ARG G C   1 
ATOM   3492 O O   . ARG C 3 45  ? -32.256 7.759   38.710  1.00 57.78  ? 45  ARG G O   1 
ATOM   3493 C CB  . ARG C 3 45  ? -34.724 9.277   37.661  1.00 34.08  ? 45  ARG G CB  1 
ATOM   3494 C CG  . ARG C 3 45  ? -34.673 10.752  38.034  1.00 53.44  ? 45  ARG G CG  1 
ATOM   3495 C CD  . ARG C 3 45  ? -35.979 11.203  38.681  1.00 68.17  ? 45  ARG G CD  1 
ATOM   3496 N NE  . ARG C 3 45  ? -36.017 10.908  40.109  1.00 89.13  ? 45  ARG G NE  1 
ATOM   3497 C CZ  . ARG C 3 45  ? -37.123 10.868  40.840  1.00 89.69  ? 45  ARG G CZ  1 
ATOM   3498 N NH1 . ARG C 3 45  ? -38.316 11.063  40.300  1.00 95.47  ? 45  ARG G NH1 1 
ATOM   3499 N NH2 . ARG C 3 45  ? -37.032 10.618  42.144  1.00 69.83  ? 45  ARG G NH2 1 
ATOM   3500 N N   . LEU C 3 46  ? -31.348 9.579   37.735  1.00 47.63  ? 46  LEU G N   1 
ATOM   3501 C CA  . LEU C 3 46  ? -30.199 9.577   38.631  1.00 43.91  ? 46  LEU G CA  1 
ATOM   3502 C C   . LEU C 3 46  ? -30.635 9.956   40.042  1.00 43.59  ? 46  LEU G C   1 
ATOM   3503 O O   . LEU C 3 46  ? -31.290 10.984  40.245  1.00 40.90  ? 46  LEU G O   1 
ATOM   3504 C CB  . LEU C 3 46  ? -29.125 10.543  38.131  1.00 46.22  ? 46  LEU G CB  1 
ATOM   3505 C CG  . LEU C 3 46  ? -27.907 10.693  39.047  1.00 43.14  ? 46  LEU G CG  1 
ATOM   3506 C CD1 . LEU C 3 46  ? -27.156 9.372   39.151  1.00 43.77  ? 46  LEU G CD1 1 
ATOM   3507 C CD2 . LEU C 3 46  ? -26.984 11.814  38.581  1.00 25.31  ? 46  LEU G CD2 1 
ATOM   3508 N N   . LEU C 3 47  ? -30.283 9.116   41.017  1.00 48.89  ? 47  LEU G N   1 
ATOM   3509 C CA  . LEU C 3 47  ? -30.555 9.389   42.426  1.00 48.17  ? 47  LEU G CA  1 
ATOM   3510 C C   . LEU C 3 47  ? -29.316 9.889   43.158  1.00 54.07  ? 47  LEU G C   1 
ATOM   3511 O O   . LEU C 3 47  ? -29.338 10.960  43.773  1.00 56.77  ? 47  LEU G O   1 
ATOM   3512 C CB  . LEU C 3 47  ? -31.088 8.132   43.126  1.00 41.03  ? 47  LEU G CB  1 
ATOM   3513 C CG  . LEU C 3 47  ? -32.483 7.629   42.768  1.00 46.56  ? 47  LEU G CG  1 
ATOM   3514 C CD1 . LEU C 3 47  ? -32.822 6.430   43.628  1.00 52.11  ? 47  LEU G CD1 1 
ATOM   3515 C CD2 . LEU C 3 47  ? -33.515 8.726   42.949  1.00 53.65  ? 47  LEU G CD2 1 
ATOM   3516 N N   . ILE C 3 48  ? -28.237 9.112   43.123  1.00 44.98  ? 48  ILE G N   1 
ATOM   3517 C CA  . ILE C 3 48  ? -27.028 9.400   43.882  1.00 47.44  ? 48  ILE G CA  1 
ATOM   3518 C C   . ILE C 3 48  ? -25.824 9.216   42.969  1.00 45.36  ? 48  ILE G C   1 
ATOM   3519 O O   . ILE C 3 48  ? -25.672 8.163   42.340  1.00 54.46  ? 48  ILE G O   1 
ATOM   3520 C CB  . ILE C 3 48  ? -26.910 8.499   45.130  1.00 51.02  ? 48  ILE G CB  1 
ATOM   3521 C CG1 . ILE C 3 48  ? -27.644 9.116   46.326  1.00 46.22  ? 48  ILE G CG1 1 
ATOM   3522 C CG2 . ILE C 3 48  ? -25.456 8.237   45.485  1.00 56.47  ? 48  ILE G CG2 1 
ATOM   3523 C CD1 . ILE C 3 48  ? -29.154 8.983   46.276  1.00 51.81  ? 48  ILE G CD1 1 
ATOM   3524 N N   . TYR C 3 49  ? -24.975 10.236  42.897  1.00 48.37  ? 49  TYR G N   1 
ATOM   3525 C CA  . TYR C 3 49  ? -23.695 10.141  42.212  1.00 51.89  ? 49  TYR G CA  1 
ATOM   3526 C C   . TYR C 3 49  ? -22.581 10.043  43.244  1.00 47.28  ? 49  TYR G C   1 
ATOM   3527 O O   . TYR C 3 49  ? -22.690 10.573  44.352  1.00 45.08  ? 49  TYR G O   1 
ATOM   3528 C CB  . TYR C 3 49  ? -23.461 11.335  41.283  1.00 48.40  ? 49  TYR G CB  1 
ATOM   3529 C CG  . TYR C 3 49  ? -23.498 12.692  41.954  1.00 41.51  ? 49  TYR G CG  1 
ATOM   3530 C CD1 . TYR C 3 49  ? -24.703 13.352  42.163  1.00 44.51  ? 49  TYR G CD1 1 
ATOM   3531 C CD2 . TYR C 3 49  ? -22.328 13.323  42.356  1.00 35.07  ? 49  TYR G CD2 1 
ATOM   3532 C CE1 . TYR C 3 49  ? -24.743 14.595  42.767  1.00 51.55  ? 49  TYR G CE1 1 
ATOM   3533 C CE2 . TYR C 3 49  ? -22.357 14.568  42.959  1.00 38.28  ? 49  TYR G CE2 1 
ATOM   3534 C CZ  . TYR C 3 49  ? -23.569 15.199  43.163  1.00 57.83  ? 49  TYR G CZ  1 
ATOM   3535 O OH  . TYR C 3 49  ? -23.617 16.438  43.763  1.00 50.58  ? 49  TYR G OH  1 
ATOM   3536 N N   . GLY C 3 50  ? -21.518 9.336   42.885  1.00 45.79  ? 50  GLY G N   1 
ATOM   3537 C CA  . GLY C 3 50  ? -20.527 8.951   43.869  1.00 46.75  ? 50  GLY G CA  1 
ATOM   3538 C C   . GLY C 3 50  ? -21.145 7.961   44.840  1.00 69.12  ? 50  GLY G C   1 
ATOM   3539 O O   . GLY C 3 50  ? -22.293 7.540   44.702  1.00 81.94  ? 50  GLY G O   1 
ATOM   3540 N N   . ALA C 3 51  ? -20.364 7.588   45.851  1.00 58.60  ? 51  ALA G N   1 
ATOM   3541 C CA  . ALA C 3 51  ? -20.882 6.627   46.818  1.00 59.03  ? 51  ALA G CA  1 
ATOM   3542 C C   . ALA C 3 51  ? -22.035 7.209   47.625  1.00 61.38  ? 51  ALA G C   1 
ATOM   3543 O O   . ALA C 3 51  ? -22.965 6.479   47.988  1.00 61.35  ? 51  ALA G O   1 
ATOM   3544 C CB  . ALA C 3 51  ? -19.770 6.154   47.751  1.00 78.03  ? 51  ALA G CB  1 
ATOM   3545 N N   . SER C 3 52  ? -22.002 8.513   47.907  1.00 60.07  ? 52  SER G N   1 
ATOM   3546 C CA  . SER C 3 52  ? -22.962 9.099   48.833  1.00 50.59  ? 52  SER G CA  1 
ATOM   3547 C C   . SER C 3 52  ? -23.578 10.420  48.391  1.00 52.89  ? 52  SER G C   1 
ATOM   3548 O O   . SER C 3 52  ? -24.573 10.829  48.999  1.00 51.22  ? 52  SER G O   1 
ATOM   3549 C CB  . SER C 3 52  ? -22.298 9.301   50.201  1.00 63.67  ? 52  SER G CB  1 
ATOM   3550 O OG  . SER C 3 52  ? -20.937 9.670   50.048  1.00 63.78  ? 52  SER G OG  1 
ATOM   3551 N N   . SER C 3 53  ? -23.043 11.101  47.379  1.00 58.42  ? 53  SER G N   1 
ATOM   3552 C CA  . SER C 3 53  ? -23.551 12.420  47.022  1.00 52.36  ? 53  SER G CA  1 
ATOM   3553 C C   . SER C 3 53  ? -24.911 12.308  46.344  1.00 49.17  ? 53  SER G C   1 
ATOM   3554 O O   . SER C 3 53  ? -25.138 11.436  45.502  1.00 54.03  ? 53  SER G O   1 
ATOM   3555 C CB  . SER C 3 53  ? -22.561 13.152  46.114  1.00 41.66  ? 53  SER G CB  1 
ATOM   3556 O OG  . SER C 3 53  ? -21.309 13.324  46.756  1.00 45.96  ? 53  SER G OG  1 
ATOM   3557 N N   . ARG C 3 54  ? -25.819 13.205  46.714  1.00 49.49  ? 54  ARG G N   1 
ATOM   3558 C CA  . ARG C 3 54  ? -27.206 13.145  46.281  1.00 47.49  ? 54  ARG G CA  1 
ATOM   3559 C C   . ARG C 3 54  ? -27.421 14.045  45.071  1.00 57.52  ? 54  ARG G C   1 
ATOM   3560 O O   . ARG C 3 54  ? -26.955 15.189  45.049  1.00 68.10  ? 54  ARG G O   1 
ATOM   3561 C CB  . ARG C 3 54  ? -28.133 13.557  47.423  1.00 43.18  ? 54  ARG G CB  1 
ATOM   3562 C CG  . ARG C 3 54  ? -29.605 13.471  47.096  1.00 60.81  ? 54  ARG G CG  1 
ATOM   3563 C CD  . ARG C 3 54  ? -30.453 13.897  48.286  1.00 75.63  ? 54  ARG G CD  1 
ATOM   3564 N NE  . ARG C 3 54  ? -30.226 13.052  49.454  1.00 89.78  ? 54  ARG G NE  1 
ATOM   3565 C CZ  . ARG C 3 54  ? -29.476 13.392  50.494  1.00 88.33  ? 54  ARG G CZ  1 
ATOM   3566 N NH1 . ARG C 3 54  ? -28.870 14.567  50.554  1.00 87.29  ? 54  ARG G NH1 1 
ATOM   3567 N NH2 . ARG C 3 54  ? -29.331 12.533  51.500  1.00 71.99  ? 54  ARG G NH2 1 
ATOM   3568 N N   . ALA C 3 55  ? -28.130 13.530  44.070  1.00 58.98  ? 55  ALA G N   1 
ATOM   3569 C CA  . ALA C 3 55  ? -28.403 14.312  42.876  1.00 57.08  ? 55  ALA G CA  1 
ATOM   3570 C C   . ALA C 3 55  ? -29.441 15.390  43.161  1.00 59.49  ? 55  ALA G C   1 
ATOM   3571 O O   . ALA C 3 55  ? -30.188 15.335  44.143  1.00 65.16  ? 55  ALA G O   1 
ATOM   3572 C CB  . ALA C 3 55  ? -28.886 13.417  41.735  1.00 59.41  ? 55  ALA G CB  1 
ATOM   3573 N N   . THR C 3 56  ? -29.480 16.382  42.276  1.00 55.05  ? 56  THR G N   1 
ATOM   3574 C CA  . THR C 3 56  ? -30.362 17.523  42.464  1.00 66.62  ? 56  THR G CA  1 
ATOM   3575 C C   . THR C 3 56  ? -31.822 17.100  42.354  1.00 67.70  ? 56  THR G C   1 
ATOM   3576 O O   . THR C 3 56  ? -32.193 16.303  41.488  1.00 67.03  ? 56  THR G O   1 
ATOM   3577 C CB  . THR C 3 56  ? -30.051 18.609  41.434  1.00 74.25  ? 56  THR G CB  1 
ATOM   3578 O OG1 . THR C 3 56  ? -30.488 18.182  40.137  1.00 63.57  ? 56  THR G OG1 1 
ATOM   3579 C CG2 . THR C 3 56  ? -28.552 18.883  41.388  1.00 64.33  ? 56  THR G CG2 1 
ATOM   3580 N N   . GLY C 3 57  ? -32.653 17.639  43.244  1.00 66.15  ? 57  GLY G N   1 
ATOM   3581 C CA  . GLY C 3 57  ? -34.075 17.368  43.206  1.00 65.85  ? 57  GLY G CA  1 
ATOM   3582 C C   . GLY C 3 57  ? -34.512 16.083  43.869  1.00 62.62  ? 57  GLY G C   1 
ATOM   3583 O O   . GLY C 3 57  ? -35.675 15.692  43.720  1.00 74.35  ? 57  GLY G O   1 
ATOM   3584 N N   . ILE C 3 58  ? -33.626 15.409  44.592  1.00 59.41  ? 58  ILE G N   1 
ATOM   3585 C CA  . ILE C 3 58  ? -33.974 14.152  45.247  1.00 62.10  ? 58  ILE G CA  1 
ATOM   3586 C C   . ILE C 3 58  ? -34.076 14.406  46.748  1.00 68.37  ? 58  ILE G C   1 
ATOM   3587 O O   . ILE C 3 58  ? -33.232 15.120  47.310  1.00 70.11  ? 58  ILE G O   1 
ATOM   3588 C CB  . ILE C 3 58  ? -32.954 13.052  44.906  1.00 60.69  ? 58  ILE G CB  1 
ATOM   3589 C CG1 . ILE C 3 58  ? -33.416 12.246  43.686  1.00 63.71  ? 58  ILE G CG1 1 
ATOM   3590 C CG2 . ILE C 3 58  ? -32.737 12.128  46.086  1.00 64.00  ? 58  ILE G CG2 1 
ATOM   3591 C CD1 . ILE C 3 58  ? -33.627 13.060  42.423  1.00 55.16  ? 58  ILE G CD1 1 
ATOM   3592 N N   . PRO C 3 59  ? -35.090 13.871  47.429  1.00 72.37  ? 59  PRO G N   1 
ATOM   3593 C CA  . PRO C 3 59  ? -35.239 14.128  48.866  1.00 74.58  ? 59  PRO G CA  1 
ATOM   3594 C C   . PRO C 3 59  ? -34.092 13.541  49.675  1.00 85.75  ? 59  PRO G C   1 
ATOM   3595 O O   . PRO C 3 59  ? -33.417 12.592  49.267  1.00 78.45  ? 59  PRO G O   1 
ATOM   3596 C CB  . PRO C 3 59  ? -36.564 13.443  49.221  1.00 74.14  ? 59  PRO G CB  1 
ATOM   3597 C CG  . PRO C 3 59  ? -37.283 13.294  47.927  1.00 75.67  ? 59  PRO G CG  1 
ATOM   3598 C CD  . PRO C 3 59  ? -36.218 13.094  46.890  1.00 66.89  ? 59  PRO G CD  1 
ATOM   3599 N N   . ASP C 3 60  ? -33.885 14.130  50.858  1.00 84.76  ? 60  ASP G N   1 
ATOM   3600 C CA  . ASP C 3 60  ? -32.779 13.732  51.723  1.00 91.77  ? 60  ASP G CA  1 
ATOM   3601 C C   . ASP C 3 60  ? -32.915 12.303  52.233  1.00 87.60  ? 60  ASP G C   1 
ATOM   3602 O O   . ASP C 3 60  ? -31.925 11.725  52.695  1.00 82.92  ? 60  ASP G O   1 
ATOM   3603 C CB  . ASP C 3 60  ? -32.671 14.695  52.908  1.00 94.30  ? 60  ASP G CB  1 
ATOM   3604 C CG  . ASP C 3 60  ? -32.289 16.105  52.487  1.00 114.20 ? 60  ASP G CG  1 
ATOM   3605 O OD1 . ASP C 3 60  ? -31.989 16.317  51.292  1.00 112.62 ? 60  ASP G OD1 1 
ATOM   3606 O OD2 . ASP C 3 60  ? -32.289 17.004  53.355  1.00 109.56 ? 60  ASP G OD2 1 
ATOM   3607 N N   . ARG C 3 61  ? -34.114 11.722  52.161  1.00 80.03  ? 61  ARG G N   1 
ATOM   3608 C CA  . ARG C 3 61  ? -34.318 10.364  52.655  1.00 75.79  ? 61  ARG G CA  1 
ATOM   3609 C C   . ARG C 3 61  ? -33.495 9.342   51.878  1.00 74.13  ? 61  ARG G C   1 
ATOM   3610 O O   . ARG C 3 61  ? -33.113 8.304   52.433  1.00 79.94  ? 61  ARG G O   1 
ATOM   3611 C CB  . ARG C 3 61  ? -35.802 10.021  52.592  1.00 72.81  ? 61  ARG G CB  1 
ATOM   3612 C CG  . ARG C 3 61  ? -36.436 10.385  51.267  1.00 78.11  ? 61  ARG G CG  1 
ATOM   3613 C CD  . ARG C 3 61  ? -37.921 10.623  51.425  1.00 70.10  ? 61  ARG G CD  1 
ATOM   3614 N NE  . ARG C 3 61  ? -38.643 10.308  50.200  1.00 82.74  ? 61  ARG G NE  1 
ATOM   3615 C CZ  . ARG C 3 61  ? -38.917 9.075   49.797  1.00 84.41  ? 61  ARG G CZ  1 
ATOM   3616 N NH1 . ARG C 3 61  ? -38.507 8.019   50.479  1.00 90.77  ? 61  ARG G NH1 1 
ATOM   3617 N NH2 . ARG C 3 61  ? -39.619 8.899   48.682  1.00 71.39  ? 61  ARG G NH2 1 
ATOM   3618 N N   . PHE C 3 62  ? -33.224 9.603   50.600  1.00 67.89  ? 62  PHE G N   1 
ATOM   3619 C CA  . PHE C 3 62  ? -32.327 8.742   49.840  1.00 70.94  ? 62  PHE G CA  1 
ATOM   3620 C C   . PHE C 3 62  ? -30.893 8.969   50.299  1.00 68.37  ? 62  PHE G C   1 
ATOM   3621 O O   . PHE C 3 62  ? -30.428 10.110  50.378  1.00 77.28  ? 62  PHE G O   1 
ATOM   3622 C CB  . PHE C 3 62  ? -32.455 9.018   48.341  1.00 65.47  ? 62  PHE G CB  1 
ATOM   3623 C CG  . PHE C 3 62  ? -33.791 8.637   47.762  1.00 73.00  ? 62  PHE G CG  1 
ATOM   3624 C CD1 . PHE C 3 62  ? -34.848 9.534   47.771  1.00 67.68  ? 62  PHE G CD1 1 
ATOM   3625 C CD2 . PHE C 3 62  ? -33.988 7.384   47.201  1.00 65.82  ? 62  PHE G CD2 1 
ATOM   3626 C CE1 . PHE C 3 62  ? -36.078 9.188   47.239  1.00 62.11  ? 62  PHE G CE1 1 
ATOM   3627 C CE2 . PHE C 3 62  ? -35.216 7.032   46.666  1.00 62.41  ? 62  PHE G CE2 1 
ATOM   3628 C CZ  . PHE C 3 62  ? -36.261 7.936   46.686  1.00 66.15  ? 62  PHE G CZ  1 
ATOM   3629 N N   . SER C 3 63  ? -30.193 7.885   50.616  1.00 57.22  ? 63  SER G N   1 
ATOM   3630 C CA  . SER C 3 63  ? -28.833 7.991   51.118  1.00 56.05  ? 63  SER G CA  1 
ATOM   3631 C C   . SER C 3 63  ? -27.988 6.865   50.550  1.00 55.65  ? 63  SER G C   1 
ATOM   3632 O O   . SER C 3 63  ? -28.424 5.711   50.502  1.00 48.14  ? 63  SER G O   1 
ATOM   3633 C CB  . SER C 3 63  ? -28.791 7.946   52.649  1.00 60.86  ? 63  SER G CB  1 
ATOM   3634 O OG  . SER C 3 63  ? -28.537 6.629   53.103  1.00 73.70  ? 63  SER G OG  1 
ATOM   3635 N N   . GLY C 3 64  ? -26.780 7.212   50.121  1.00 54.76  ? 64  GLY G N   1 
ATOM   3636 C CA  . GLY C 3 64  ? -25.816 6.249   49.628  1.00 53.61  ? 64  GLY G CA  1 
ATOM   3637 C C   . GLY C 3 64  ? -24.698 6.076   50.635  1.00 60.11  ? 64  GLY G C   1 
ATOM   3638 O O   . GLY C 3 64  ? -24.383 6.996   51.395  1.00 63.30  ? 64  GLY G O   1 
ATOM   3639 N N   . SER C 3 65  ? -24.099 4.888   50.641  1.00 54.72  ? 65  SER G N   1 
ATOM   3640 C CA  . SER C 3 65  ? -23.050 4.562   51.594  1.00 47.07  ? 65  SER G CA  1 
ATOM   3641 C C   . SER C 3 65  ? -22.134 3.514   50.980  1.00 49.02  ? 65  SER G C   1 
ATOM   3642 O O   . SER C 3 65  ? -22.400 2.978   49.901  1.00 65.34  ? 65  SER G O   1 
ATOM   3643 C CB  . SER C 3 65  ? -23.631 4.053   52.917  1.00 59.25  ? 65  SER G CB  1 
ATOM   3644 O OG  . SER C 3 65  ? -24.691 4.878   53.371  1.00 67.52  ? 65  SER G OG  1 
ATOM   3645 N N   . GLY C 3 66  ? -21.048 3.226   51.687  1.00 49.91  ? 66  GLY G N   1 
ATOM   3646 C CA  . GLY C 3 66  ? -20.132 2.176   51.299  1.00 64.06  ? 66  GLY G CA  1 
ATOM   3647 C C   . GLY C 3 66  ? -18.968 2.673   50.460  1.00 52.57  ? 66  GLY G C   1 
ATOM   3648 O O   . GLY C 3 66  ? -18.953 3.789   49.938  1.00 55.49  ? 66  GLY G O   1 
ATOM   3649 N N   . SER C 3 67  ? -17.961 1.810   50.343  1.00 48.19  ? 67  SER G N   1 
ATOM   3650 C CA  . SER C 3 67  ? -16.781 2.105   49.547  1.00 48.49  ? 67  SER G CA  1 
ATOM   3651 C C   . SER C 3 67  ? -16.156 0.791   49.107  1.00 58.78  ? 67  SER G C   1 
ATOM   3652 O O   . SER C 3 67  ? -16.445 -0.272  49.663  1.00 58.56  ? 67  SER G O   1 
ATOM   3653 C CB  . SER C 3 67  ? -15.769 2.948   50.329  1.00 66.00  ? 67  SER G CB  1 
ATOM   3654 O OG  . SER C 3 67  ? -16.366 4.132   50.830  1.00 79.94  ? 67  SER G OG  1 
ATOM   3655 N N   . GLY C 3 68  ? -15.295 0.879   48.096  1.00 57.40  ? 68  GLY G N   1 
ATOM   3656 C CA  . GLY C 3 68  ? -14.577 -0.287  47.624  1.00 60.36  ? 68  GLY G CA  1 
ATOM   3657 C C   . GLY C 3 68  ? -15.443 -1.276  46.871  1.00 62.24  ? 68  GLY G C   1 
ATOM   3658 O O   . GLY C 3 68  ? -15.818 -1.032  45.721  1.00 71.97  ? 68  GLY G O   1 
ATOM   3659 N N   . THR C 3 69  ? -15.755 -2.406  47.506  1.00 70.71  ? 69  THR G N   1 
ATOM   3660 C CA  . THR C 3 69  ? -16.563 -3.444  46.885  1.00 71.36  ? 69  THR G CA  1 
ATOM   3661 C C   . THR C 3 69  ? -17.973 -3.552  47.446  1.00 65.18  ? 69  THR G C   1 
ATOM   3662 O O   . THR C 3 69  ? -18.783 -4.293  46.880  1.00 70.61  ? 69  THR G O   1 
ATOM   3663 C CB  . THR C 3 69  ? -15.883 -4.814  47.026  1.00 67.74  ? 69  THR G CB  1 
ATOM   3664 O OG1 . THR C 3 69  ? -15.739 -5.135  48.416  1.00 65.57  ? 69  THR G OG1 1 
ATOM   3665 C CG2 . THR C 3 69  ? -14.521 -4.811  46.356  1.00 59.41  ? 69  THR G CG2 1 
ATOM   3666 N N   . ASP C 3 70  ? -18.288 -2.860  48.538  1.00 55.27  ? 70  ASP G N   1 
ATOM   3667 C CA  . ASP C 3 70  ? -19.596 -2.955  49.174  1.00 59.62  ? 70  ASP G CA  1 
ATOM   3668 C C   . ASP C 3 70  ? -20.244 -1.579  49.217  1.00 56.69  ? 70  ASP G C   1 
ATOM   3669 O O   . ASP C 3 70  ? -19.645 -0.624  49.721  1.00 66.26  ? 70  ASP G O   1 
ATOM   3670 C CB  . ASP C 3 70  ? -19.481 -3.531  50.591  1.00 77.65  ? 70  ASP G CB  1 
ATOM   3671 C CG  . ASP C 3 70  ? -18.888 -4.935  50.611  1.00 90.15  ? 70  ASP G CG  1 
ATOM   3672 O OD1 . ASP C 3 70  ? -19.129 -5.707  49.657  1.00 75.83  ? 70  ASP G OD1 1 
ATOM   3673 O OD2 . ASP C 3 70  ? -18.184 -5.269  51.588  1.00 96.27  ? 70  ASP G OD2 1 
ATOM   3674 N N   . PHE C 3 71  ? -21.470 -1.484  48.701  1.00 62.92  ? 71  PHE G N   1 
ATOM   3675 C CA  . PHE C 3 71  ? -22.212 -0.231  48.668  1.00 55.99  ? 71  PHE G CA  1 
ATOM   3676 C C   . PHE C 3 71  ? -23.651 -0.482  49.092  1.00 54.62  ? 71  PHE G C   1 
ATOM   3677 O O   . PHE C 3 71  ? -24.185 -1.578  48.908  1.00 60.75  ? 71  PHE G O   1 
ATOM   3678 C CB  . PHE C 3 71  ? -22.190 0.407   47.276  1.00 58.55  ? 71  PHE G CB  1 
ATOM   3679 C CG  . PHE C 3 71  ? -20.811 0.723   46.772  1.00 54.27  ? 71  PHE G CG  1 
ATOM   3680 C CD1 . PHE C 3 71  ? -20.234 1.957   47.025  1.00 53.38  ? 71  PHE G CD1 1 
ATOM   3681 C CD2 . PHE C 3 71  ? -20.093 -0.210  46.041  1.00 45.04  ? 71  PHE G CD2 1 
ATOM   3682 C CE1 . PHE C 3 71  ? -18.967 2.252   46.562  1.00 58.18  ? 71  PHE G CE1 1 
ATOM   3683 C CE2 . PHE C 3 71  ? -18.826 0.080   45.577  1.00 45.54  ? 71  PHE G CE2 1 
ATOM   3684 C CZ  . PHE C 3 71  ? -18.263 1.312   45.838  1.00 55.27  ? 71  PHE G CZ  1 
ATOM   3685 N N   . THR C 3 72  ? -24.278 0.552   49.648  1.00 55.15  ? 72  THR G N   1 
ATOM   3686 C CA  . THR C 3 72  ? -25.618 0.431   50.207  1.00 57.83  ? 72  THR G CA  1 
ATOM   3687 C C   . THR C 3 72  ? -26.447 1.649   49.835  1.00 62.41  ? 72  THR G C   1 
ATOM   3688 O O   . THR C 3 72  ? -25.973 2.783   49.948  1.00 65.68  ? 72  THR G O   1 
ATOM   3689 C CB  . THR C 3 72  ? -25.570 0.292   51.733  1.00 63.18  ? 72  THR G CB  1 
ATOM   3690 O OG1 . THR C 3 72  ? -24.697 -0.786  52.091  1.00 72.39  ? 72  THR G OG1 1 
ATOM   3691 C CG2 . THR C 3 72  ? -26.963 0.028   52.291  1.00 62.21  ? 72  THR G CG2 1 
ATOM   3692 N N   . LEU C 3 73  ? -27.681 1.415   49.404  1.00 60.54  ? 73  LEU G N   1 
ATOM   3693 C CA  . LEU C 3 73  ? -28.654 2.475   49.183  1.00 69.38  ? 73  LEU G CA  1 
ATOM   3694 C C   . LEU C 3 73  ? -29.776 2.308   50.198  1.00 69.08  ? 73  LEU G C   1 
ATOM   3695 O O   . LEU C 3 73  ? -30.419 1.254   50.247  1.00 75.39  ? 73  LEU G O   1 
ATOM   3696 C CB  . LEU C 3 73  ? -29.202 2.440   47.755  1.00 65.04  ? 73  LEU G CB  1 
ATOM   3697 C CG  . LEU C 3 73  ? -30.377 3.389   47.493  1.00 72.75  ? 73  LEU G CG  1 
ATOM   3698 C CD1 . LEU C 3 73  ? -29.965 4.843   47.678  1.00 75.12  ? 73  LEU G CD1 1 
ATOM   3699 C CD2 . LEU C 3 73  ? -30.976 3.168   46.111  1.00 57.72  ? 73  LEU G CD2 1 
ATOM   3700 N N   . THR C 3 74  ? -30.006 3.339   51.005  1.00 60.00  ? 74  THR G N   1 
ATOM   3701 C CA  . THR C 3 74  ? -31.021 3.300   52.049  1.00 59.90  ? 74  THR G CA  1 
ATOM   3702 C C   . THR C 3 74  ? -32.079 4.349   51.751  1.00 63.03  ? 74  THR G C   1 
ATOM   3703 O O   . THR C 3 74  ? -31.769 5.542   51.659  1.00 66.79  ? 74  THR G O   1 
ATOM   3704 C CB  . THR C 3 74  ? -30.406 3.534   53.429  1.00 64.75  ? 74  THR G CB  1 
ATOM   3705 O OG1 . THR C 3 74  ? -29.540 2.439   53.757  1.00 62.97  ? 74  THR G OG1 1 
ATOM   3706 C CG2 . THR C 3 74  ? -31.501 3.645   54.479  1.00 72.91  ? 74  THR G CG2 1 
ATOM   3707 N N   . ILE C 3 75  ? -33.322 3.904   51.609  1.00 68.35  ? 75  ILE G N   1 
ATOM   3708 C CA  . ILE C 3 75  ? -34.455 4.783   51.357  1.00 69.57  ? 75  ILE G CA  1 
ATOM   3709 C C   . ILE C 3 75  ? -35.321 4.774   52.607  1.00 75.50  ? 75  ILE G C   1 
ATOM   3710 O O   . ILE C 3 75  ? -35.984 3.774   52.909  1.00 75.86  ? 75  ILE G O   1 
ATOM   3711 C CB  . ILE C 3 75  ? -35.260 4.347   50.126  1.00 69.03  ? 75  ILE G CB  1 
ATOM   3712 C CG1 . ILE C 3 75  ? -34.330 4.029   48.955  1.00 73.02  ? 75  ILE G CG1 1 
ATOM   3713 C CG2 . ILE C 3 75  ? -36.245 5.431   49.734  1.00 71.84  ? 75  ILE G CG2 1 
ATOM   3714 C CD1 . ILE C 3 75  ? -34.369 2.577   48.533  1.00 67.10  ? 75  ILE G CD1 1 
ATOM   3715 N N   . SER C 3 76  ? -35.320 5.884   53.333  1.00 79.76  ? 76  SER G N   1 
ATOM   3716 C CA  . SER C 3 76  ? -36.189 6.043   54.486  1.00 76.78  ? 76  SER G CA  1 
ATOM   3717 C C   . SER C 3 76  ? -37.475 6.748   54.071  1.00 85.03  ? 76  SER G C   1 
ATOM   3718 O O   . SER C 3 76  ? -37.552 7.372   53.010  1.00 97.83  ? 76  SER G O   1 
ATOM   3719 C CB  . SER C 3 76  ? -35.484 6.832   55.588  1.00 77.57  ? 76  SER G CB  1 
ATOM   3720 O OG  . SER C 3 76  ? -34.246 6.228   55.920  1.00 86.63  ? 76  SER G OG  1 
ATOM   3721 N N   . ARG C 3 77  ? -38.494 6.630   54.924  1.00 75.09  ? 77  ARG G N   1 
ATOM   3722 C CA  . ARG C 3 77  ? -39.796 7.254   54.694  1.00 74.30  ? 77  ARG G CA  1 
ATOM   3723 C C   . ARG C 3 77  ? -40.383 6.804   53.351  1.00 84.34  ? 77  ARG G C   1 
ATOM   3724 O O   . ARG C 3 77  ? -40.660 7.607   52.458  1.00 91.55  ? 77  ARG G O   1 
ATOM   3725 C CB  . ARG C 3 77  ? -39.679 8.783   54.773  1.00 76.06  ? 77  ARG G CB  1 
ATOM   3726 C CG  . ARG C 3 77  ? -40.997 9.542   54.829  1.00 87.35  ? 77  ARG G CG  1 
ATOM   3727 C CD  . ARG C 3 77  ? -40.774 11.018  54.531  1.00 94.05  ? 77  ARG G CD  1 
ATOM   3728 N NE  . ARG C 3 77  ? -41.995 11.802  54.674  1.00 106.01 ? 77  ARG G NE  1 
ATOM   3729 C CZ  . ARG C 3 77  ? -42.099 13.089  54.372  1.00 99.97  ? 77  ARG G CZ  1 
ATOM   3730 N NH1 . ARG C 3 77  ? -41.075 13.770  53.882  1.00 87.68  ? 77  ARG G NH1 1 
ATOM   3731 N NH2 . ARG C 3 77  ? -43.259 13.710  54.566  1.00 87.70  ? 77  ARG G NH2 1 
ATOM   3732 N N   . LEU C 3 78  ? -40.560 5.487   53.220  1.00 78.36  ? 78  LEU G N   1 
ATOM   3733 C CA  . LEU C 3 78  ? -41.047 4.902   51.974  1.00 79.58  ? 78  LEU G CA  1 
ATOM   3734 C C   . LEU C 3 78  ? -42.445 5.399   51.626  1.00 95.63  ? 78  LEU G C   1 
ATOM   3735 O O   . LEU C 3 78  ? -43.418 5.071   52.313  1.00 102.20 ? 78  LEU G O   1 
ATOM   3736 C CB  . LEU C 3 78  ? -41.047 3.373   52.055  1.00 64.97  ? 78  LEU G CB  1 
ATOM   3737 C CG  . LEU C 3 78  ? -39.682 2.690   51.993  1.00 80.36  ? 78  LEU G CG  1 
ATOM   3738 C CD1 . LEU C 3 78  ? -39.819 1.177   52.098  1.00 82.22  ? 78  LEU G CD1 1 
ATOM   3739 C CD2 . LEU C 3 78  ? -38.967 3.078   50.712  1.00 86.39  ? 78  LEU G CD2 1 
ATOM   3740 N N   . GLU C 3 79  ? -42.552 6.186   50.553  1.00 101.13 ? 79  GLU G N   1 
ATOM   3741 C CA  . GLU C 3 79  ? -43.791 6.756   50.051  1.00 94.24  ? 79  GLU G CA  1 
ATOM   3742 C C   . GLU C 3 79  ? -44.240 6.022   48.789  1.00 99.77  ? 79  GLU G C   1 
ATOM   3743 O O   . GLU C 3 79  ? -43.402 5.526   48.032  1.00 109.52 ? 79  GLU G O   1 
ATOM   3744 C CB  . GLU C 3 79  ? -43.615 8.248   49.740  1.00 88.27  ? 79  GLU G CB  1 
ATOM   3745 C CG  . GLU C 3 79  ? -43.303 9.101   50.960  1.00 89.79  ? 79  GLU G CG  1 
ATOM   3746 C CD  . GLU C 3 79  ? -44.506 9.278   51.866  1.00 103.85 ? 79  GLU G CD  1 
ATOM   3747 O OE1 . GLU C 3 79  ? -45.494 9.902   51.424  1.00 102.22 ? 79  GLU G OE1 1 
ATOM   3748 O OE2 . GLU C 3 79  ? -44.469 8.785   53.014  1.00 99.01  ? 79  GLU G OE2 1 
ATOM   3749 N N   . PRO C 3 80  ? -45.548 5.950   48.521  1.00 102.82 ? 80  PRO G N   1 
ATOM   3750 C CA  . PRO C 3 80  ? -46.013 5.186   47.349  1.00 100.43 ? 80  PRO G CA  1 
ATOM   3751 C C   . PRO C 3 80  ? -45.450 5.677   46.019  1.00 99.05  ? 80  PRO G C   1 
ATOM   3752 O O   . PRO C 3 80  ? -45.463 4.912   45.046  1.00 85.17  ? 80  PRO G O   1 
ATOM   3753 C CB  . PRO C 3 80  ? -47.538 5.347   47.410  1.00 96.46  ? 80  PRO G CB  1 
ATOM   3754 C CG  . PRO C 3 80  ? -47.827 5.592   48.859  1.00 98.79  ? 80  PRO G CG  1 
ATOM   3755 C CD  . PRO C 3 80  ? -46.669 6.413   49.358  1.00 99.16  ? 80  PRO G CD  1 
ATOM   3756 N N   . GLU C 3 81  ? -44.962 6.922   45.943  1.00 106.97 ? 81  GLU G N   1 
ATOM   3757 C CA  . GLU C 3 81  ? -44.288 7.407   44.739  1.00 110.36 ? 81  GLU G CA  1 
ATOM   3758 C C   . GLU C 3 81  ? -42.999 6.646   44.452  1.00 110.77 ? 81  GLU G C   1 
ATOM   3759 O O   . GLU C 3 81  ? -42.513 6.667   43.315  1.00 113.13 ? 81  GLU G O   1 
ATOM   3760 C CB  . GLU C 3 81  ? -43.986 8.903   44.868  1.00 94.65  ? 81  GLU G CB  1 
ATOM   3761 C CG  . GLU C 3 81  ? -43.019 9.247   45.997  1.00 100.81 ? 81  GLU G CG  1 
ATOM   3762 C CD  . GLU C 3 81  ? -42.430 10.639  45.861  1.00 119.38 ? 81  GLU G CD  1 
ATOM   3763 O OE1 . GLU C 3 81  ? -42.939 11.423  45.032  1.00 127.23 ? 81  GLU G OE1 1 
ATOM   3764 O OE2 . GLU C 3 81  ? -41.453 10.948  46.576  1.00 116.84 ? 81  GLU G OE2 1 
ATOM   3765 N N   . ASP C 3 82  ? -42.441 5.983   45.464  1.00 99.67  ? 82  ASP G N   1 
ATOM   3766 C CA  . ASP C 3 82  ? -41.290 5.092   45.370  1.00 83.36  ? 82  ASP G CA  1 
ATOM   3767 C C   . ASP C 3 82  ? -41.734 3.749   44.817  1.00 78.86  ? 82  ASP G C   1 
ATOM   3768 O O   . ASP C 3 82  ? -42.720 3.674   44.073  1.00 78.93  ? 82  ASP G O   1 
ATOM   3769 C CB  . ASP C 3 82  ? -40.624 4.896   46.730  1.00 68.94  ? 82  ASP G CB  1 
ATOM   3770 C CG  . ASP C 3 82  ? -40.281 6.201   47.405  1.00 78.36  ? 82  ASP G CG  1 
ATOM   3771 O OD1 . ASP C 3 82  ? -40.485 7.270   46.789  1.00 84.50  ? 82  ASP G OD1 1 
ATOM   3772 O OD2 . ASP C 3 82  ? -39.793 6.153   48.552  1.00 86.90  ? 82  ASP G OD2 1 
ATOM   3773 N N   . PHE C 3 83  ? -40.974 2.699   45.134  1.00 77.86  ? 83  PHE G N   1 
ATOM   3774 C CA  . PHE C 3 83  ? -41.295 1.342   44.719  1.00 90.57  ? 83  PHE G CA  1 
ATOM   3775 C C   . PHE C 3 83  ? -41.134 1.164   43.208  1.00 64.78  ? 83  PHE G C   1 
ATOM   3776 O O   . PHE C 3 83  ? -42.085 0.782   42.518  1.00 64.12  ? 83  PHE G O   1 
ATOM   3777 C CB  . PHE C 3 83  ? -42.711 0.988   45.204  1.00 99.50  ? 83  PHE G CB  1 
ATOM   3778 C CG  . PHE C 3 83  ? -42.915 1.207   46.697  1.00 98.89  ? 83  PHE G CG  1 
ATOM   3779 C CD1 . PHE C 3 83  ? -43.258 2.461   47.199  1.00 95.59  ? 83  PHE G CD1 1 
ATOM   3780 C CD2 . PHE C 3 83  ? -42.723 0.172   47.596  1.00 88.05  ? 83  PHE G CD2 1 
ATOM   3781 C CE1 . PHE C 3 83  ? -43.427 2.682   48.554  1.00 84.36  ? 83  PHE G CE1 1 
ATOM   3782 C CE2 . PHE C 3 83  ? -42.905 0.376   48.961  1.00 95.48  ? 83  PHE G CE2 1 
ATOM   3783 C CZ  . PHE C 3 83  ? -43.255 1.651   49.444  1.00 94.58  ? 83  PHE G CZ  1 
ATOM   3784 N N   . ALA C 3 84  ? -39.933 1.446   42.689  1.00 51.53  ? 84  ALA G N   1 
ATOM   3785 C CA  . ALA C 3 84  ? -39.578 1.098   41.308  1.00 50.24  ? 84  ALA G CA  1 
ATOM   3786 C C   . ALA C 3 84  ? -38.358 0.174   41.283  1.00 55.47  ? 84  ALA G C   1 
ATOM   3787 O O   . ALA C 3 84  ? -37.976 -0.375  42.319  1.00 71.84  ? 84  ALA G O   1 
ATOM   3788 C CB  . ALA C 3 84  ? -39.314 2.354   40.468  1.00 61.55  ? 84  ALA G CB  1 
ATOM   3789 N N   . VAL C 3 85  ? -37.756 -0.032  40.117  1.00 45.45  ? 85  VAL G N   1 
ATOM   3790 C CA  . VAL C 3 85  ? -36.551 -0.853  40.014  1.00 51.86  ? 85  VAL G CA  1 
ATOM   3791 C C   . VAL C 3 85  ? -35.315 0.038   40.123  1.00 59.28  ? 85  VAL G C   1 
ATOM   3792 O O   . VAL C 3 85  ? -35.219 1.070   39.445  1.00 61.98  ? 85  VAL G O   1 
ATOM   3793 C CB  . VAL C 3 85  ? -36.540 -1.662  38.705  1.00 46.83  ? 85  VAL G CB  1 
ATOM   3794 C CG1 . VAL C 3 85  ? -35.204 -2.390  38.539  1.00 35.84  ? 85  VAL G CG1 1 
ATOM   3795 C CG2 . VAL C 3 85  ? -37.680 -2.672  38.701  1.00 66.82  ? 85  VAL G CG2 1 
ATOM   3796 N N   . TYR C 3 86  ? -34.373 -0.353  40.981  1.00 57.16  ? 86  TYR G N   1 
ATOM   3797 C CA  . TYR C 3 86  ? -33.191 0.449   41.290  1.00 45.09  ? 86  TYR G CA  1 
ATOM   3798 C C   . TYR C 3 86  ? -31.933 -0.266  40.812  1.00 46.28  ? 86  TYR G C   1 
ATOM   3799 O O   . TYR C 3 86  ? -31.705 -1.432  41.155  1.00 50.01  ? 86  TYR G O   1 
ATOM   3800 C CB  . TYR C 3 86  ? -33.094 0.738   42.794  1.00 38.97  ? 86  TYR G CB  1 
ATOM   3801 C CG  . TYR C 3 86  ? -34.193 1.635   43.328  1.00 42.21  ? 86  TYR G CG  1 
ATOM   3802 C CD1 . TYR C 3 86  ? -35.498 1.177   43.422  1.00 51.61  ? 86  TYR G CD1 1 
ATOM   3803 C CD2 . TYR C 3 86  ? -33.929 2.938   43.739  1.00 40.76  ? 86  TYR G CD2 1 
ATOM   3804 C CE1 . TYR C 3 86  ? -36.515 1.984   43.898  1.00 54.50  ? 86  TYR G CE1 1 
ATOM   3805 C CE2 . TYR C 3 86  ? -34.948 3.758   44.226  1.00 54.03  ? 86  TYR G CE2 1 
ATOM   3806 C CZ  . TYR C 3 86  ? -36.241 3.269   44.302  1.00 58.02  ? 86  TYR G CZ  1 
ATOM   3807 O OH  . TYR C 3 86  ? -37.275 4.049   44.776  1.00 54.13  ? 86  TYR G OH  1 
ATOM   3808 N N   . TYR C 3 87  ? -31.117 0.438   40.035  1.00 47.06  ? 87  TYR G N   1 
ATOM   3809 C CA  . TYR C 3 87  ? -29.860 -0.086  39.526  1.00 51.91  ? 87  TYR G CA  1 
ATOM   3810 C C   . TYR C 3 87  ? -28.690 0.675   40.133  1.00 51.24  ? 87  TYR G C   1 
ATOM   3811 O O   . TYR C 3 87  ? -28.817 1.839   40.522  1.00 53.86  ? 87  TYR G O   1 
ATOM   3812 C CB  . TYR C 3 87  ? -29.777 0.015   38.000  1.00 43.69  ? 87  TYR G CB  1 
ATOM   3813 C CG  . TYR C 3 87  ? -30.861 -0.720  37.251  1.00 51.47  ? 87  TYR G CG  1 
ATOM   3814 C CD1 . TYR C 3 87  ? -30.678 -2.031  36.831  1.00 51.65  ? 87  TYR G CD1 1 
ATOM   3815 C CD2 . TYR C 3 87  ? -32.062 -0.095  36.944  1.00 53.32  ? 87  TYR G CD2 1 
ATOM   3816 C CE1 . TYR C 3 87  ? -31.668 -2.704  36.135  1.00 52.39  ? 87  TYR G CE1 1 
ATOM   3817 C CE2 . TYR C 3 87  ? -33.056 -0.756  36.249  1.00 54.51  ? 87  TYR G CE2 1 
ATOM   3818 C CZ  . TYR C 3 87  ? -32.855 -2.060  35.848  1.00 58.38  ? 87  TYR G CZ  1 
ATOM   3819 O OH  . TYR C 3 87  ? -33.847 -2.715  35.156  1.00 53.36  ? 87  TYR G OH  1 
ATOM   3820 N N   . CYS C 3 88  ? -27.546 0.007   40.211  1.00 53.54  ? 88  CYS G N   1 
ATOM   3821 C CA  . CYS C 3 88  ? -26.305 0.640   40.617  1.00 50.99  ? 88  CYS G CA  1 
ATOM   3822 C C   . CYS C 3 88  ? -25.270 0.443   39.519  1.00 57.53  ? 88  CYS G C   1 
ATOM   3823 O O   . CYS C 3 88  ? -25.152 -0.648  38.953  1.00 63.33  ? 88  CYS G O   1 
ATOM   3824 C CB  . CYS C 3 88  ? -25.800 0.084   41.956  1.00 65.40  ? 88  CYS G CB  1 
ATOM   3825 S SG  . CYS C 3 88  ? -25.488 -1.698  42.020  1.00 82.25  ? 88  CYS G SG  1 
ATOM   3826 N N   . GLN C 3 89  ? -24.539 1.510   39.207  1.00 55.06  ? 89  GLN G N   1 
ATOM   3827 C CA  . GLN C 3 89  ? -23.584 1.515   38.108  1.00 51.10  ? 89  GLN G CA  1 
ATOM   3828 C C   . GLN C 3 89  ? -22.230 2.004   38.601  1.00 46.45  ? 89  GLN G C   1 
ATOM   3829 O O   . GLN C 3 89  ? -22.150 2.986   39.345  1.00 44.68  ? 89  GLN G O   1 
ATOM   3830 C CB  . GLN C 3 89  ? -24.088 2.402   36.960  1.00 44.92  ? 89  GLN G CB  1 
ATOM   3831 C CG  . GLN C 3 89  ? -23.060 2.687   35.881  1.00 47.36  ? 89  GLN G CG  1 
ATOM   3832 C CD  . GLN C 3 89  ? -22.713 4.159   35.795  1.00 51.04  ? 89  GLN G CD  1 
ATOM   3833 O OE1 . GLN C 3 89  ? -23.461 5.014   36.270  1.00 48.02  ? 89  GLN G OE1 1 
ATOM   3834 N NE2 . GLN C 3 89  ? -21.571 4.462   35.192  1.00 52.65  ? 89  GLN G NE2 1 
ATOM   3835 N N   . GLN C 3 90  ? -21.167 1.319   38.183  1.00 29.88  ? 90  GLN G N   1 
ATOM   3836 C CA  . GLN C 3 90  ? -19.804 1.700   38.521  1.00 41.59  ? 90  GLN G CA  1 
ATOM   3837 C C   . GLN C 3 90  ? -19.165 2.449   37.359  1.00 52.58  ? 90  GLN G C   1 
ATOM   3838 O O   . GLN C 3 90  ? -19.503 2.224   36.194  1.00 52.14  ? 90  GLN G O   1 
ATOM   3839 C CB  . GLN C 3 90  ? -18.960 0.472   38.879  1.00 39.13  ? 90  GLN G CB  1 
ATOM   3840 C CG  . GLN C 3 90  ? -18.710 -0.501  37.725  1.00 41.43  ? 90  GLN G CG  1 
ATOM   3841 C CD  . GLN C 3 90  ? -17.479 -0.155  36.898  1.00 46.44  ? 90  GLN G CD  1 
ATOM   3842 O OE1 . GLN C 3 90  ? -16.537 0.462   37.393  1.00 50.69  ? 90  GLN G OE1 1 
ATOM   3843 N NE2 . GLN C 3 90  ? -17.488 -0.548  35.629  1.00 46.73  ? 90  GLN G NE2 1 
ATOM   3844 N N   . TYR C 3 91  ? -18.234 3.354   37.687  1.00 51.91  ? 91  TYR G N   1 
ATOM   3845 C CA  . TYR C 3 91  ? -17.475 4.058   36.658  1.00 57.63  ? 91  TYR G CA  1 
ATOM   3846 C C   . TYR C 3 91  ? -16.005 4.203   37.032  1.00 57.56  ? 91  TYR G C   1 
ATOM   3847 O O   . TYR C 3 91  ? -15.355 5.178   36.638  1.00 58.06  ? 91  TYR G O   1 
ATOM   3848 C CB  . TYR C 3 91  ? -18.074 5.436   36.361  1.00 52.93  ? 91  TYR G CB  1 
ATOM   3849 C CG  . TYR C 3 91  ? -18.394 6.279   37.577  1.00 44.23  ? 91  TYR G CG  1 
ATOM   3850 C CD1 . TYR C 3 91  ? -19.628 6.179   38.206  1.00 43.56  ? 91  TYR G CD1 1 
ATOM   3851 C CD2 . TYR C 3 91  ? -17.473 7.190   38.082  1.00 47.09  ? 91  TYR G CD2 1 
ATOM   3852 C CE1 . TYR C 3 91  ? -19.934 6.952   39.311  1.00 40.29  ? 91  TYR G CE1 1 
ATOM   3853 C CE2 . TYR C 3 91  ? -17.772 7.970   39.191  1.00 45.68  ? 91  TYR G CE2 1 
ATOM   3854 C CZ  . TYR C 3 91  ? -19.005 7.845   39.799  1.00 44.77  ? 91  TYR G CZ  1 
ATOM   3855 O OH  . TYR C 3 91  ? -19.311 8.614   40.899  1.00 35.25  ? 91  TYR G OH  1 
ATOM   3856 N N   . GLY C 3 92  ? -15.465 3.246   37.784  1.00 54.34  ? 92  GLY G N   1 
ATOM   3857 C CA  . GLY C 3 92  ? -14.055 3.259   38.120  1.00 61.18  ? 92  GLY G CA  1 
ATOM   3858 C C   . GLY C 3 92  ? -13.160 2.739   37.012  1.00 62.89  ? 92  GLY G C   1 
ATOM   3859 O O   . GLY C 3 92  ? -12.050 3.242   36.814  1.00 58.83  ? 92  GLY G O   1 
ATOM   3860 N N   . SER C 3 93  ? -13.624 1.725   36.284  1.00 56.60  ? 93  SER G N   1 
ATOM   3861 C CA  . SER C 3 93  ? -12.851 1.136   35.201  1.00 63.49  ? 93  SER G CA  1 
ATOM   3862 C C   . SER C 3 93  ? -13.756 0.888   34.006  1.00 61.77  ? 93  SER G C   1 
ATOM   3863 O O   . SER C 3 93  ? -14.908 0.476   34.167  1.00 56.37  ? 93  SER G O   1 
ATOM   3864 C CB  . SER C 3 93  ? -12.197 -0.177  35.635  1.00 64.86  ? 93  SER G CB  1 
ATOM   3865 O OG  . SER C 3 93  ? -13.189 -1.150  35.909  1.00 75.68  ? 93  SER G OG  1 
ATOM   3866 N N   . SER C 3 94  ? -13.228 1.142   32.810  1.00 64.53  ? 94  SER G N   1 
ATOM   3867 C CA  . SER C 3 94  ? -13.981 0.916   31.588  1.00 56.83  ? 94  SER G CA  1 
ATOM   3868 C C   . SER C 3 94  ? -14.016 -0.572  31.246  1.00 69.38  ? 94  SER G C   1 
ATOM   3869 O O   . SER C 3 94  ? -13.059 -1.302  31.513  1.00 76.83  ? 94  SER G O   1 
ATOM   3870 C CB  . SER C 3 94  ? -13.364 1.691   30.432  1.00 48.71  ? 94  SER G CB  1 
ATOM   3871 O OG  . SER C 3 94  ? -13.339 3.079   30.711  1.00 76.40  ? 94  SER G OG  1 
ATOM   3872 N N   . PRO C 3 95  ? -15.112 -1.045  30.646  1.00 68.86  ? 95  PRO G N   1 
ATOM   3873 C CA  . PRO C 3 95  ? -16.348 -0.319  30.333  1.00 54.77  ? 95  PRO G CA  1 
ATOM   3874 C C   . PRO C 3 95  ? -17.258 -0.219  31.548  1.00 51.07  ? 95  PRO G C   1 
ATOM   3875 O O   . PRO C 3 95  ? -17.223 -1.078  32.425  1.00 57.58  ? 95  PRO G O   1 
ATOM   3876 C CB  . PRO C 3 95  ? -16.964 -1.168  29.217  1.00 49.12  ? 95  PRO G CB  1 
ATOM   3877 C CG  . PRO C 3 95  ? -16.551 -2.566  29.577  1.00 66.52  ? 95  PRO G CG  1 
ATOM   3878 C CD  . PRO C 3 95  ? -15.159 -2.434  30.155  1.00 64.08  ? 95  PRO G CD  1 
ATOM   3879 N N   . ARG C 3 96  ? -18.079 0.823   31.625  1.00 48.33  ? 96  ARG G N   1 
ATOM   3880 C CA  . ARG C 3 96  ? -19.010 0.958   32.735  1.00 43.78  ? 96  ARG G CA  1 
ATOM   3881 C C   . ARG C 3 96  ? -20.070 -0.133  32.680  1.00 49.26  ? 96  ARG G C   1 
ATOM   3882 O O   . ARG C 3 96  ? -20.520 -0.532  31.603  1.00 57.51  ? 96  ARG G O   1 
ATOM   3883 C CB  . ARG C 3 96  ? -19.662 2.336   32.712  1.00 46.07  ? 96  ARG G CB  1 
ATOM   3884 C CG  . ARG C 3 96  ? -18.797 3.414   33.324  1.00 54.53  ? 96  ARG G CG  1 
ATOM   3885 C CD  . ARG C 3 96  ? -19.266 4.782   32.905  1.00 54.21  ? 96  ARG G CD  1 
ATOM   3886 N NE  . ARG C 3 96  ? -19.112 4.961   31.468  1.00 71.56  ? 96  ARG G NE  1 
ATOM   3887 C CZ  . ARG C 3 96  ? -19.480 6.050   30.808  1.00 64.13  ? 96  ARG G CZ  1 
ATOM   3888 N NH1 . ARG C 3 96  ? -20.039 7.077   31.428  1.00 56.38  ? 96  ARG G NH1 1 
ATOM   3889 N NH2 . ARG C 3 96  ? -19.283 6.110   29.494  1.00 46.72  ? 96  ARG G NH2 1 
ATOM   3890 N N   . THR C 3 97  ? -20.465 -0.619  33.853  1.00 50.91  ? 97  THR G N   1 
ATOM   3891 C CA  . THR C 3 97  ? -21.394 -1.731  33.969  1.00 40.84  ? 97  THR G CA  1 
ATOM   3892 C C   . THR C 3 97  ? -22.472 -1.409  34.994  1.00 50.96  ? 97  THR G C   1 
ATOM   3893 O O   . THR C 3 97  ? -22.259 -0.615  35.915  1.00 47.98  ? 97  THR G O   1 
ATOM   3894 C CB  . THR C 3 97  ? -20.667 -3.014  34.375  1.00 51.60  ? 97  THR G CB  1 
ATOM   3895 O OG1 . THR C 3 97  ? -19.927 -2.775  35.579  1.00 59.54  ? 97  THR G OG1 1 
ATOM   3896 C CG2 . THR C 3 97  ? -19.711 -3.457  33.277  1.00 45.19  ? 97  THR G CG2 1 
ATOM   3897 N N   . PHE C 3 98  ? -23.629 -2.043  34.830  1.00 50.12  ? 98  PHE G N   1 
ATOM   3898 C CA  . PHE C 3 98  ? -24.769 -1.868  35.718  1.00 55.90  ? 98  PHE G CA  1 
ATOM   3899 C C   . PHE C 3 98  ? -25.013 -3.138  36.525  1.00 65.52  ? 98  PHE G C   1 
ATOM   3900 O O   . PHE C 3 98  ? -24.464 -4.206  36.241  1.00 55.70  ? 98  PHE G O   1 
ATOM   3901 C CB  . PHE C 3 98  ? -26.031 -1.504  34.925  1.00 59.12  ? 98  PHE G CB  1 
ATOM   3902 C CG  . PHE C 3 98  ? -25.964 -0.166  34.251  1.00 48.84  ? 98  PHE G CG  1 
ATOM   3903 C CD1 . PHE C 3 98  ? -25.346 -0.026  33.020  1.00 40.34  ? 98  PHE G CD1 1 
ATOM   3904 C CD2 . PHE C 3 98  ? -26.530 0.951   34.843  1.00 44.51  ? 98  PHE G CD2 1 
ATOM   3905 C CE1 . PHE C 3 98  ? -25.285 1.203   32.395  1.00 39.37  ? 98  PHE G CE1 1 
ATOM   3906 C CE2 . PHE C 3 98  ? -26.472 2.185   34.223  1.00 39.68  ? 98  PHE G CE2 1 
ATOM   3907 C CZ  . PHE C 3 98  ? -25.850 2.309   32.997  1.00 39.53  ? 98  PHE G CZ  1 
ATOM   3908 N N   . GLY C 3 99  ? -25.853 -3.003  37.556  1.00 66.31  ? 99  GLY G N   1 
ATOM   3909 C CA  . GLY C 3 99  ? -26.326 -4.155  38.291  1.00 58.91  ? 99  GLY G CA  1 
ATOM   3910 C C   . GLY C 3 99  ? -27.558 -4.765  37.650  1.00 61.83  ? 99  GLY G C   1 
ATOM   3911 O O   . GLY C 3 99  ? -28.154 -4.204  36.733  1.00 70.11  ? 99  GLY G O   1 
ATOM   3912 N N   . GLN C 3 100 ? -27.940 -5.939  38.154  1.00 74.92  ? 100 GLN G N   1 
ATOM   3913 C CA  . GLN C 3 100 ? -29.104 -6.633  37.616  1.00 68.63  ? 100 GLN G CA  1 
ATOM   3914 C C   . GLN C 3 100 ? -30.419 -5.985  38.027  1.00 51.83  ? 100 GLN G C   1 
ATOM   3915 O O   . GLN C 3 100 ? -31.466 -6.349  37.483  1.00 59.56  ? 100 GLN G O   1 
ATOM   3916 C CB  . GLN C 3 100 ? -29.081 -8.101  38.049  1.00 72.84  ? 100 GLN G CB  1 
ATOM   3917 C CG  . GLN C 3 100 ? -27.871 -8.874  37.533  1.00 88.13  ? 100 GLN G CG  1 
ATOM   3918 C CD  . GLN C 3 100 ? -27.784 -8.893  36.014  1.00 82.80  ? 100 GLN G CD  1 
ATOM   3919 O OE1 . GLN C 3 100 ? -27.187 -8.007  35.401  1.00 69.41  ? 100 GLN G OE1 1 
ATOM   3920 N NE2 . GLN C 3 100 ? -28.376 -9.912  35.401  1.00 81.93  ? 100 GLN G NE2 1 
ATOM   3921 N N   . GLY C 3 101 ? -30.391 -5.037  38.955  1.00 44.49  ? 101 GLY G N   1 
ATOM   3922 C CA  . GLY C 3 101 ? -31.589 -4.356  39.388  1.00 41.51  ? 101 GLY G CA  1 
ATOM   3923 C C   . GLY C 3 101 ? -32.178 -4.974  40.645  1.00 54.44  ? 101 GLY G C   1 
ATOM   3924 O O   . GLY C 3 101 ? -31.910 -6.124  41.000  1.00 62.52  ? 101 GLY G O   1 
ATOM   3925 N N   . THR C 3 102 ? -32.996 -4.180  41.334  1.00 50.75  ? 102 THR G N   1 
ATOM   3926 C CA  . THR C 3 102 ? -33.673 -4.612  42.557  1.00 49.66  ? 102 THR G CA  1 
ATOM   3927 C C   . THR C 3 102 ? -35.092 -4.053  42.510  1.00 56.12  ? 102 THR G C   1 
ATOM   3928 O O   . THR C 3 102 ? -35.299 -2.854  42.721  1.00 59.73  ? 102 THR G O   1 
ATOM   3929 C CB  . THR C 3 102 ? -32.932 -4.145  43.807  1.00 63.80  ? 102 THR G CB  1 
ATOM   3930 O OG1 . THR C 3 102 ? -31.663 -4.807  43.892  1.00 60.33  ? 102 THR G OG1 1 
ATOM   3931 C CG2 . THR C 3 102 ? -33.746 -4.450  45.060  1.00 51.82  ? 102 THR G CG2 1 
ATOM   3932 N N   . LYS C 3 103 ? -36.062 -4.918  42.222  1.00 63.53  ? 103 LYS G N   1 
ATOM   3933 C CA  . LYS C 3 103 ? -37.454 -4.490  42.179  1.00 72.84  ? 103 LYS G CA  1 
ATOM   3934 C C   . LYS C 3 103 ? -37.947 -4.165  43.583  1.00 66.74  ? 103 LYS G C   1 
ATOM   3935 O O   . LYS C 3 103 ? -37.709 -4.925  44.527  1.00 70.15  ? 103 LYS G O   1 
ATOM   3936 C CB  . LYS C 3 103 ? -38.329 -5.571  41.543  1.00 80.73  ? 103 LYS G CB  1 
ATOM   3937 C CG  . LYS C 3 103 ? -39.823 -5.253  41.555  1.00 73.13  ? 103 LYS G CG  1 
ATOM   3938 C CD  . LYS C 3 103 ? -40.609 -6.233  40.695  1.00 76.46  ? 103 LYS G CD  1 
ATOM   3939 C CE  . LYS C 3 103 ? -40.336 -6.006  39.218  1.00 78.25  ? 103 LYS G CE  1 
ATOM   3940 N NZ  . LYS C 3 103 ? -40.782 -4.651  38.792  1.00 88.61  ? 103 LYS G NZ  1 
ATOM   3941 N N   . LEU C 3 104 ? -38.628 -3.030  43.718  1.00 68.56  ? 104 LEU G N   1 
ATOM   3942 C CA  . LEU C 3 104 ? -39.155 -2.563  44.995  1.00 67.36  ? 104 LEU G CA  1 
ATOM   3943 C C   . LEU C 3 104 ? -40.676 -2.613  44.921  1.00 76.43  ? 104 LEU G C   1 
ATOM   3944 O O   . LEU C 3 104 ? -41.287 -1.956  44.070  1.00 76.20  ? 104 LEU G O   1 
ATOM   3945 C CB  . LEU C 3 104 ? -38.659 -1.149  45.315  1.00 75.27  ? 104 LEU G CB  1 
ATOM   3946 C CG  . LEU C 3 104 ? -38.337 -0.776  46.766  1.00 70.76  ? 104 LEU G CG  1 
ATOM   3947 C CD1 . LEU C 3 104 ? -37.752 0.622   46.832  1.00 79.60  ? 104 LEU G CD1 1 
ATOM   3948 C CD2 . LEU C 3 104 ? -39.605 -0.862  47.617  1.00 76.50  ? 104 LEU G CD2 1 
ATOM   3949 N N   . GLU C 3 105 ? -41.281 -3.402  45.800  1.00 78.39  ? 105 GLU G N   1 
ATOM   3950 C CA  . GLU C 3 105 ? -42.721 -3.603  45.812  1.00 71.29  ? 105 GLU G CA  1 
ATOM   3951 C C   . GLU C 3 105 ? -43.311 -3.011  47.086  1.00 69.74  ? 105 GLU G C   1 
ATOM   3952 O O   . GLU C 3 105 ? -42.681 -3.042  48.148  1.00 73.81  ? 105 GLU G O   1 
ATOM   3953 C CB  . GLU C 3 105 ? -43.060 -5.098  45.692  1.00 66.74  ? 105 GLU G CB  1 
ATOM   3954 C CG  . GLU C 3 105 ? -44.548 -5.453  45.754  1.00 84.30  ? 105 GLU G CG  1 
ATOM   3955 C CD  . GLU C 3 105 ? -44.807 -6.960  45.731  1.00 88.18  ? 105 GLU G CD  1 
ATOM   3956 O OE1 . GLU C 3 105 ? -44.072 -7.695  45.034  1.00 83.98  ? 105 GLU G OE1 1 
ATOM   3957 O OE2 . GLU C 3 105 ? -45.751 -7.411  46.415  1.00 86.10  ? 105 GLU G OE2 1 
ATOM   3958 N N   . ILE C 3 106 ? -44.502 -2.438  46.964  1.00 68.70  ? 106 ILE G N   1 
ATOM   3959 C CA  . ILE C 3 106 ? -45.271 -1.931  48.094  1.00 71.60  ? 106 ILE G CA  1 
ATOM   3960 C C   . ILE C 3 106 ? -46.049 -3.087  48.701  1.00 75.53  ? 106 ILE G C   1 
ATOM   3961 O O   . ILE C 3 106 ? -46.451 -4.029  48.009  1.00 72.76  ? 106 ILE G O   1 
ATOM   3962 C CB  . ILE C 3 106 ? -46.203 -0.782  47.655  1.00 77.56  ? 106 ILE G CB  1 
ATOM   3963 C CG1 . ILE C 3 106 ? -46.258 0.308   48.723  1.00 79.82  ? 106 ILE G CG1 1 
ATOM   3964 C CG2 . ILE C 3 106 ? -47.597 -1.300  47.406  1.00 84.44  ? 106 ILE G CG2 1 
ATOM   3965 C CD1 . ILE C 3 106 ? -46.816 1.619   48.220  1.00 75.63  ? 106 ILE G CD1 1 
ATOM   3966 N N   . LYS C 3 107 ? -46.253 -3.031  50.012  1.00 79.45  ? 107 LYS G N   1 
ATOM   3967 C CA  . LYS C 3 107 ? -46.967 -4.074  50.731  1.00 80.42  ? 107 LYS G CA  1 
ATOM   3968 C C   . LYS C 3 107 ? -48.241 -3.493  51.325  1.00 75.99  ? 107 LYS G C   1 
ATOM   3969 O O   . LYS C 3 107 ? -48.234 -2.384  51.871  1.00 65.94  ? 107 LYS G O   1 
ATOM   3970 C CB  . LYS C 3 107 ? -46.082 -4.693  51.821  1.00 73.32  ? 107 LYS G CB  1 
ATOM   3971 C CG  . LYS C 3 107 ? -46.388 -6.153  52.128  1.00 69.55  ? 107 LYS G CG  1 
ATOM   3972 C CD  . LYS C 3 107 ? -45.130 -6.913  52.536  1.00 67.44  ? 107 LYS G CD  1 
ATOM   3973 C CE  . LYS C 3 107 ? -45.384 -8.412  52.597  1.00 73.78  ? 107 LYS G CE  1 
ATOM   3974 N NZ  . LYS C 3 107 ? -44.146 -9.178  52.917  1.00 66.44  ? 107 LYS G NZ  1 
ATOM   3975 N N   . ARG C 3 108 ? -49.336 -4.238  51.204  1.00 69.69  ? 108 ARG G N   1 
ATOM   3976 C CA  . ARG C 3 108 ? -50.651 -3.750  51.606  1.00 68.48  ? 108 ARG G CA  1 
ATOM   3977 C C   . ARG C 3 108 ? -51.468 -4.923  52.136  1.00 66.24  ? 108 ARG G C   1 
ATOM   3978 O O   . ARG C 3 108 ? -50.970 -6.047  52.259  1.00 59.41  ? 108 ARG G O   1 
ATOM   3979 C CB  . ARG C 3 108 ? -51.352 -3.058  50.430  1.00 62.78  ? 108 ARG G CB  1 
ATOM   3980 C CG  . ARG C 3 108 ? -51.544 -3.955  49.221  1.00 65.63  ? 108 ARG G CG  1 
ATOM   3981 C CD  . ARG C 3 108 ? -52.785 -3.551  48.459  1.00 55.74  ? 108 ARG G CD  1 
ATOM   3982 N NE  . ARG C 3 108 ? -53.990 -3.833  49.229  1.00 55.61  ? 108 ARG G NE  1 
ATOM   3983 C CZ  . ARG C 3 108 ? -55.182 -3.315  48.972  1.00 58.62  ? 108 ARG G CZ  1 
ATOM   3984 N NH1 . ARG C 3 108 ? -55.359 -2.438  47.996  1.00 52.56  ? 108 ARG G NH1 1 
ATOM   3985 N NH2 . ARG C 3 108 ? -56.223 -3.683  49.713  1.00 53.77  ? 108 ARG G NH2 1 
ATOM   3986 N N   . THR C 3 109 ? -52.733 -4.655  52.448  1.00 66.92  ? 109 THR G N   1 
ATOM   3987 C CA  . THR C 3 109 ? -53.638 -5.693  52.917  1.00 76.14  ? 109 THR G CA  1 
ATOM   3988 C C   . THR C 3 109 ? -53.922 -6.697  51.802  1.00 82.79  ? 109 THR G C   1 
ATOM   3989 O O   . THR C 3 109 ? -53.839 -6.379  50.612  1.00 72.08  ? 109 THR G O   1 
ATOM   3990 C CB  . THR C 3 109 ? -54.948 -5.073  53.412  1.00 60.30  ? 109 THR G CB  1 
ATOM   3991 O OG1 . THR C 3 109 ? -55.752 -4.688  52.291  1.00 79.25  ? 109 THR G OG1 1 
ATOM   3992 C CG2 . THR C 3 109 ? -54.660 -3.842  54.249  1.00 44.25  ? 109 THR G CG2 1 
ATOM   3993 N N   . VAL C 3 110 ? -54.245 -7.929  52.198  1.00 80.24  ? 110 VAL G N   1 
ATOM   3994 C CA  . VAL C 3 110 ? -54.611 -8.950  51.224  1.00 63.15  ? 110 VAL G CA  1 
ATOM   3995 C C   . VAL C 3 110 ? -55.963 -8.595  50.619  1.00 63.25  ? 110 VAL G C   1 
ATOM   3996 O O   . VAL C 3 110 ? -56.902 -8.216  51.332  1.00 63.64  ? 110 VAL G O   1 
ATOM   3997 C CB  . VAL C 3 110 ? -54.620 -10.343 51.875  1.00 50.94  ? 110 VAL G CB  1 
ATOM   3998 C CG1 . VAL C 3 110 ? -55.563 -10.385 53.073  1.00 62.40  ? 110 VAL G CG1 1 
ATOM   3999 C CG2 . VAL C 3 110 ? -54.988 -11.412 50.857  1.00 52.11  ? 110 VAL G CG2 1 
ATOM   4000 N N   . ALA C 3 111 ? -56.055 -8.669  49.292  1.00 63.45  ? 111 ALA G N   1 
ATOM   4001 C CA  . ALA C 3 111 ? -57.291 -8.379  48.573  1.00 60.81  ? 111 ALA G CA  1 
ATOM   4002 C C   . ALA C 3 111 ? -57.602 -9.547  47.652  1.00 58.63  ? 111 ALA G C   1 
ATOM   4003 O O   . ALA C 3 111 ? -56.775 -9.912  46.810  1.00 57.11  ? 111 ALA G O   1 
ATOM   4004 C CB  . ALA C 3 111 ? -57.179 -7.077  47.775  1.00 52.88  ? 111 ALA G CB  1 
ATOM   4005 N N   . ALA C 3 112 ? -58.782 -10.134 47.817  1.00 48.10  ? 112 ALA G N   1 
ATOM   4006 C CA  . ALA C 3 112 ? -59.182 -11.231 46.952  1.00 49.54  ? 112 ALA G CA  1 
ATOM   4007 C C   . ALA C 3 112 ? -59.430 -10.714 45.537  1.00 57.32  ? 112 ALA G C   1 
ATOM   4008 O O   . ALA C 3 112 ? -60.001 -9.633  45.360  1.00 54.66  ? 112 ALA G O   1 
ATOM   4009 C CB  . ALA C 3 112 ? -60.437 -11.915 47.491  1.00 48.41  ? 112 ALA G CB  1 
ATOM   4010 N N   . PRO C 3 113 ? -58.998 -11.448 44.516  1.00 61.40  ? 113 PRO G N   1 
ATOM   4011 C CA  . PRO C 3 113 ? -59.230 -11.004 43.138  1.00 50.93  ? 113 PRO G CA  1 
ATOM   4012 C C   . PRO C 3 113 ? -60.700 -11.079 42.756  1.00 59.66  ? 113 PRO G C   1 
ATOM   4013 O O   . PRO C 3 113 ? -61.468 -11.883 43.289  1.00 58.73  ? 113 PRO G O   1 
ATOM   4014 C CB  . PRO C 3 113 ? -58.393 -11.983 42.307  1.00 46.75  ? 113 PRO G CB  1 
ATOM   4015 C CG  . PRO C 3 113 ? -58.293 -13.205 43.162  1.00 50.58  ? 113 PRO G CG  1 
ATOM   4016 C CD  . PRO C 3 113 ? -58.239 -12.708 44.577  1.00 57.19  ? 113 PRO G CD  1 
ATOM   4017 N N   . SER C 3 114 ? -61.085 -10.220 41.815  1.00 59.11  ? 114 SER G N   1 
ATOM   4018 C CA  . SER C 3 114 ? -62.399 -10.275 41.187  1.00 57.74  ? 114 SER G CA  1 
ATOM   4019 C C   . SER C 3 114 ? -62.253 -11.001 39.856  1.00 61.25  ? 114 SER G C   1 
ATOM   4020 O O   . SER C 3 114 ? -61.543 -10.526 38.962  1.00 60.53  ? 114 SER G O   1 
ATOM   4021 C CB  . SER C 3 114 ? -62.974 -8.874  40.977  1.00 54.67  ? 114 SER G CB  1 
ATOM   4022 O OG  . SER C 3 114 ? -63.145 -8.193  42.208  1.00 63.93  ? 114 SER G OG  1 
ATOM   4023 N N   . VAL C 3 115 ? -62.921 -12.144 39.725  1.00 45.14  ? 115 VAL G N   1 
ATOM   4024 C CA  . VAL C 3 115 ? -62.726 -13.039 38.591  1.00 50.01  ? 115 VAL G CA  1 
ATOM   4025 C C   . VAL C 3 115 ? -63.848 -12.818 37.586  1.00 54.82  ? 115 VAL G C   1 
ATOM   4026 O O   . VAL C 3 115 ? -65.032 -12.947 37.921  1.00 48.43  ? 115 VAL G O   1 
ATOM   4027 C CB  . VAL C 3 115 ? -62.671 -14.508 39.037  1.00 46.11  ? 115 VAL G CB  1 
ATOM   4028 C CG1 . VAL C 3 115 ? -62.226 -15.390 37.882  1.00 46.80  ? 115 VAL G CG1 1 
ATOM   4029 C CG2 . VAL C 3 115 ? -61.739 -14.665 40.224  1.00 43.12  ? 115 VAL G CG2 1 
ATOM   4030 N N   . PHE C 3 116 ? -63.473 -12.492 36.352  1.00 56.16  ? 116 PHE G N   1 
ATOM   4031 C CA  . PHE C 3 116 ? -64.407 -12.343 35.248  1.00 45.36  ? 116 PHE G CA  1 
ATOM   4032 C C   . PHE C 3 116 ? -63.931 -13.200 34.085  1.00 53.99  ? 116 PHE G C   1 
ATOM   4033 O O   . PHE C 3 116 ? -62.730 -13.431 33.919  1.00 58.55  ? 116 PHE G O   1 
ATOM   4034 C CB  . PHE C 3 116 ? -64.527 -10.880 34.797  1.00 51.02  ? 116 PHE G CB  1 
ATOM   4035 C CG  . PHE C 3 116 ? -64.712 -9.902  35.925  1.00 62.92  ? 116 PHE G CG  1 
ATOM   4036 C CD1 . PHE C 3 116 ? -65.933 -9.784  36.566  1.00 73.25  ? 116 PHE G CD1 1 
ATOM   4037 C CD2 . PHE C 3 116 ? -63.668 -9.082  36.329  1.00 65.83  ? 116 PHE G CD2 1 
ATOM   4038 C CE1 . PHE C 3 116 ? -66.107 -8.878  37.598  1.00 75.18  ? 116 PHE G CE1 1 
ATOM   4039 C CE2 . PHE C 3 116 ? -63.837 -8.174  37.359  1.00 52.48  ? 116 PHE G CE2 1 
ATOM   4040 C CZ  . PHE C 3 116 ? -65.057 -8.072  37.993  1.00 55.18  ? 116 PHE G CZ  1 
ATOM   4041 N N   . ILE C 3 117 ? -64.875 -13.670 33.275  1.00 51.32  ? 117 ILE G N   1 
ATOM   4042 C CA  . ILE C 3 117 ? -64.565 -14.518 32.131  1.00 49.50  ? 117 ILE G CA  1 
ATOM   4043 C C   . ILE C 3 117 ? -65.273 -13.965 30.900  1.00 47.37  ? 117 ILE G C   1 
ATOM   4044 O O   . ILE C 3 117 ? -66.425 -13.524 30.980  1.00 50.91  ? 117 ILE G O   1 
ATOM   4045 C CB  . ILE C 3 117 ? -64.953 -15.991 32.398  1.00 51.13  ? 117 ILE G CB  1 
ATOM   4046 C CG1 . ILE C 3 117 ? -64.598 -16.873 31.198  1.00 48.44  ? 117 ILE G CG1 1 
ATOM   4047 C CG2 . ILE C 3 117 ? -66.429 -16.115 32.771  1.00 47.75  ? 117 ILE G CG2 1 
ATOM   4048 C CD1 . ILE C 3 117 ? -63.992 -18.206 31.583  1.00 42.03  ? 117 ILE G CD1 1 
ATOM   4049 N N   . PHE C 3 118 ? -64.574 -13.960 29.768  1.00 47.95  ? 118 PHE G N   1 
ATOM   4050 C CA  . PHE C 3 118 ? -65.118 -13.430 28.516  1.00 45.27  ? 118 PHE G CA  1 
ATOM   4051 C C   . PHE C 3 118 ? -65.122 -14.509 27.448  1.00 46.37  ? 118 PHE G C   1 
ATOM   4052 O O   . PHE C 3 118 ? -64.038 -14.960 27.031  1.00 51.68  ? 118 PHE G O   1 
ATOM   4053 C CB  . PHE C 3 118 ? -64.305 -12.225 28.041  1.00 45.00  ? 118 PHE G CB  1 
ATOM   4054 C CG  . PHE C 3 118 ? -64.303 -11.082 29.008  1.00 47.47  ? 118 PHE G CG  1 
ATOM   4055 C CD1 . PHE C 3 118 ? -65.330 -10.155 29.003  1.00 46.00  ? 118 PHE G CD1 1 
ATOM   4056 C CD2 . PHE C 3 118 ? -63.274 -10.931 29.922  1.00 48.45  ? 118 PHE G CD2 1 
ATOM   4057 C CE1 . PHE C 3 118 ? -65.335 -9.101  29.891  1.00 52.82  ? 118 PHE G CE1 1 
ATOM   4058 C CE2 . PHE C 3 118 ? -63.272 -9.880  30.813  1.00 52.79  ? 118 PHE G CE2 1 
ATOM   4059 C CZ  . PHE C 3 118 ? -64.304 -8.963  30.799  1.00 57.48  ? 118 PHE G CZ  1 
ATOM   4060 N N   . PRO C 3 119 ? -66.286 -14.963 26.970  1.00 44.65  ? 119 PRO G N   1 
ATOM   4061 C CA  . PRO C 3 119 ? -66.288 -15.892 25.835  1.00 50.69  ? 119 PRO G CA  1 
ATOM   4062 C C   . PRO C 3 119 ? -65.784 -15.208 24.579  1.00 48.82  ? 119 PRO G C   1 
ATOM   4063 O O   . PRO C 3 119 ? -65.813 -13.972 24.480  1.00 58.84  ? 119 PRO G O   1 
ATOM   4064 C CB  . PRO C 3 119 ? -67.770 -16.289 25.701  1.00 31.72  ? 119 PRO G CB  1 
ATOM   4065 C CG  . PRO C 3 119 ? -68.373 -15.968 27.020  1.00 46.65  ? 119 PRO G CG  1 
ATOM   4066 C CD  . PRO C 3 119 ? -67.637 -14.766 27.526  1.00 49.86  ? 119 PRO G CD  1 
ATOM   4067 N N   . PRO C 3 120 ? -65.279 -15.966 23.606  1.00 44.69  ? 120 PRO G N   1 
ATOM   4068 C CA  . PRO C 3 120 ? -64.789 -15.346 22.370  1.00 50.07  ? 120 PRO G CA  1 
ATOM   4069 C C   . PRO C 3 120 ? -65.904 -14.623 21.628  1.00 50.75  ? 120 PRO G C   1 
ATOM   4070 O O   . PRO C 3 120 ? -67.050 -15.073 21.596  1.00 53.00  ? 120 PRO G O   1 
ATOM   4071 C CB  . PRO C 3 120 ? -64.254 -16.535 21.563  1.00 40.62  ? 120 PRO G CB  1 
ATOM   4072 C CG  . PRO C 3 120 ? -64.968 -17.720 22.121  1.00 42.15  ? 120 PRO G CG  1 
ATOM   4073 C CD  . PRO C 3 120 ? -65.170 -17.436 23.575  1.00 43.05  ? 120 PRO G CD  1 
ATOM   4074 N N   . SER C 3 121 ? -65.554 -13.485 21.031  1.00 56.03  ? 121 SER G N   1 
ATOM   4075 C CA  . SER C 3 121 ? -66.523 -12.693 20.294  1.00 60.14  ? 121 SER G CA  1 
ATOM   4076 C C   . SER C 3 121 ? -66.909 -13.386 18.993  1.00 65.61  ? 121 SER G C   1 
ATOM   4077 O O   . SER C 3 121 ? -66.122 -14.127 18.399  1.00 63.21  ? 121 SER G O   1 
ATOM   4078 C CB  . SER C 3 121 ? -65.960 -11.303 19.994  1.00 57.24  ? 121 SER G CB  1 
ATOM   4079 O OG  . SER C 3 121 ? -64.775 -11.393 19.222  1.00 54.97  ? 121 SER G OG  1 
ATOM   4080 N N   . ASP C 3 122 ? -68.145 -13.135 18.549  1.00 65.03  ? 122 ASP G N   1 
ATOM   4081 C CA  . ASP C 3 122 ? -68.605 -13.722 17.293  1.00 66.45  ? 122 ASP G CA  1 
ATOM   4082 C C   . ASP C 3 122 ? -67.779 -13.229 16.114  1.00 65.57  ? 122 ASP G C   1 
ATOM   4083 O O   . ASP C 3 122 ? -67.572 -13.973 15.148  1.00 60.23  ? 122 ASP G O   1 
ATOM   4084 C CB  . ASP C 3 122 ? -70.085 -13.411 17.075  1.00 63.67  ? 122 ASP G CB  1 
ATOM   4085 C CG  . ASP C 3 122 ? -70.987 -14.180 18.019  1.00 78.25  ? 122 ASP G CG  1 
ATOM   4086 O OD1 . ASP C 3 122 ? -70.947 -13.904 19.237  1.00 85.04  ? 122 ASP G OD1 1 
ATOM   4087 O OD2 . ASP C 3 122 ? -71.736 -15.061 17.545  1.00 86.30  ? 122 ASP G OD2 1 
ATOM   4088 N N   . GLU C 3 123 ? -67.300 -11.985 16.174  1.00 58.92  ? 123 GLU G N   1 
ATOM   4089 C CA  . GLU C 3 123 ? -66.453 -11.467 15.105  1.00 62.03  ? 123 GLU G CA  1 
ATOM   4090 C C   . GLU C 3 123 ? -65.153 -12.256 15.002  1.00 60.32  ? 123 GLU G C   1 
ATOM   4091 O O   . GLU C 3 123 ? -64.682 -12.553 13.897  1.00 57.86  ? 123 GLU G O   1 
ATOM   4092 C CB  . GLU C 3 123 ? -66.168 -9.985  15.338  1.00 54.36  ? 123 GLU G CB  1 
ATOM   4093 C CG  . GLU C 3 123 ? -65.324 -9.351  14.253  1.00 62.61  ? 123 GLU G CG  1 
ATOM   4094 C CD  . GLU C 3 123 ? -65.049 -7.888  14.517  1.00 88.80  ? 123 GLU G CD  1 
ATOM   4095 O OE1 . GLU C 3 123 ? -65.317 -7.425  15.647  1.00 80.77  ? 123 GLU G OE1 1 
ATOM   4096 O OE2 . GLU C 3 123 ? -64.565 -7.201  13.594  1.00 103.36 ? 123 GLU G OE2 1 
ATOM   4097 N N   . GLN C 3 124 ? -64.558 -12.604 16.144  1.00 57.73  ? 124 GLN G N   1 
ATOM   4098 C CA  . GLN C 3 124 ? -63.325 -13.383 16.126  1.00 51.28  ? 124 GLN G CA  1 
ATOM   4099 C C   . GLN C 3 124 ? -63.559 -14.783 15.575  1.00 65.95  ? 124 GLN G C   1 
ATOM   4100 O O   . GLN C 3 124 ? -62.697 -15.333 14.878  1.00 59.56  ? 124 GLN G O   1 
ATOM   4101 C CB  . GLN C 3 124 ? -62.734 -13.461 17.530  1.00 53.40  ? 124 GLN G CB  1 
ATOM   4102 C CG  . GLN C 3 124 ? -61.401 -14.175 17.571  1.00 50.02  ? 124 GLN G CG  1 
ATOM   4103 C CD  . GLN C 3 124 ? -60.878 -14.344 18.974  1.00 47.26  ? 124 GLN G CD  1 
ATOM   4104 O OE1 . GLN C 3 124 ? -59.781 -14.861 19.177  1.00 39.49  ? 124 GLN G OE1 1 
ATOM   4105 N NE2 . GLN C 3 124 ? -61.661 -13.908 19.956  1.00 46.79  ? 124 GLN G NE2 1 
ATOM   4106 N N   . LEU C 3 125 ? -64.714 -15.380 15.884  1.00 64.97  ? 125 LEU G N   1 
ATOM   4107 C CA  . LEU C 3 125 ? -64.996 -16.735 15.421  1.00 65.86  ? 125 LEU G CA  1 
ATOM   4108 C C   . LEU C 3 125 ? -65.047 -16.811 13.899  1.00 72.19  ? 125 LEU G C   1 
ATOM   4109 O O   . LEU C 3 125 ? -64.629 -17.818 13.314  1.00 64.22  ? 125 LEU G O   1 
ATOM   4110 C CB  . LEU C 3 125 ? -66.309 -17.234 16.028  1.00 60.02  ? 125 LEU G CB  1 
ATOM   4111 C CG  . LEU C 3 125 ? -66.393 -17.231 17.557  1.00 60.98  ? 125 LEU G CG  1 
ATOM   4112 C CD1 . LEU C 3 125 ? -67.683 -17.879 18.039  1.00 48.22  ? 125 LEU G CD1 1 
ATOM   4113 C CD2 . LEU C 3 125 ? -65.187 -17.924 18.164  1.00 55.10  ? 125 LEU G CD2 1 
ATOM   4114 N N   . LYS C 3 126 ? -65.544 -15.758 13.243  1.00 68.04  ? 126 LYS G N   1 
ATOM   4115 C CA  . LYS C 3 126 ? -65.592 -15.745 11.784  1.00 65.58  ? 126 LYS G CA  1 
ATOM   4116 C C   . LYS C 3 126 ? -64.200 -15.866 11.169  1.00 69.22  ? 126 LYS G C   1 
ATOM   4117 O O   . LYS C 3 126 ? -64.057 -16.419 10.073  1.00 69.35  ? 126 LYS G O   1 
ATOM   4118 C CB  . LYS C 3 126 ? -66.289 -14.472 11.296  1.00 67.62  ? 126 LYS G CB  1 
ATOM   4119 C CG  . LYS C 3 126 ? -67.786 -14.431 11.577  1.00 72.65  ? 126 LYS G CG  1 
ATOM   4120 C CD  . LYS C 3 126 ? -68.284 -13.001 11.773  1.00 85.05  ? 126 LYS G CD  1 
ATOM   4121 C CE  . LYS C 3 126 ? -67.907 -12.093 10.609  1.00 90.60  ? 126 LYS G CE  1 
ATOM   4122 N NZ  . LYS C 3 126 ? -68.284 -10.670 10.866  1.00 67.04  ? 126 LYS G NZ  1 
ATOM   4123 N N   . SER C 3 127 ? -63.166 -15.369 11.856  1.00 61.67  ? 127 SER G N   1 
ATOM   4124 C CA  . SER C 3 127 ? -61.803 -15.502 11.351  1.00 54.41  ? 127 SER G CA  1 
ATOM   4125 C C   . SER C 3 127 ? -61.268 -16.922 11.482  1.00 60.41  ? 127 SER G C   1 
ATOM   4126 O O   . SER C 3 127 ? -60.357 -17.296 10.735  1.00 73.67  ? 127 SER G O   1 
ATOM   4127 C CB  . SER C 3 127 ? -60.871 -14.538 12.086  1.00 59.89  ? 127 SER G CB  1 
ATOM   4128 O OG  . SER C 3 127 ? -60.856 -14.805 13.478  1.00 76.38  ? 127 SER G OG  1 
ATOM   4129 N N   . GLY C 3 128 ? -61.797 -17.716 12.411  1.00 61.67  ? 128 GLY G N   1 
ATOM   4130 C CA  . GLY C 3 128 ? -61.369 -19.096 12.580  1.00 51.86  ? 128 GLY G CA  1 
ATOM   4131 C C   . GLY C 3 128 ? -60.698 -19.416 13.900  1.00 47.92  ? 128 GLY G C   1 
ATOM   4132 O O   . GLY C 3 128 ? -60.335 -20.581 14.118  1.00 56.13  ? 128 GLY G O   1 
ATOM   4133 N N   . THR C 3 129 ? -60.515 -18.456 14.800  1.00 46.29  ? 129 THR G N   1 
ATOM   4134 C CA  . THR C 3 129 ? -59.902 -18.703 16.094  1.00 46.74  ? 129 THR G CA  1 
ATOM   4135 C C   . THR C 3 129 ? -60.839 -18.243 17.201  1.00 50.98  ? 129 THR G C   1 
ATOM   4136 O O   . THR C 3 129 ? -61.691 -17.372 16.997  1.00 52.21  ? 129 THR G O   1 
ATOM   4137 C CB  . THR C 3 129 ? -58.548 -17.991 16.223  1.00 49.22  ? 129 THR G CB  1 
ATOM   4138 O OG1 . THR C 3 129 ? -58.742 -16.572 16.170  1.00 68.17  ? 129 THR G OG1 1 
ATOM   4139 C CG2 . THR C 3 129 ? -57.612 -18.415 15.097  1.00 48.59  ? 129 THR G CG2 1 
ATOM   4140 N N   . ALA C 3 130 ? -60.685 -18.855 18.372  1.00 53.60  ? 130 ALA G N   1 
ATOM   4141 C CA  . ALA C 3 130 ? -61.462 -18.516 19.555  1.00 39.58  ? 130 ALA G CA  1 
ATOM   4142 C C   . ALA C 3 130 ? -60.509 -18.231 20.704  1.00 42.89  ? 130 ALA G C   1 
ATOM   4143 O O   . ALA C 3 130 ? -59.586 -19.013 20.956  1.00 52.50  ? 130 ALA G O   1 
ATOM   4144 C CB  . ALA C 3 130 ? -62.426 -19.644 19.932  1.00 40.30  ? 130 ALA G CB  1 
ATOM   4145 N N   . SER C 3 131 ? -60.729 -17.113 21.392  1.00 39.95  ? 131 SER G N   1 
ATOM   4146 C CA  . SER C 3 131 ? -59.920 -16.717 22.539  1.00 40.10  ? 131 SER G CA  1 
ATOM   4147 C C   . SER C 3 131 ? -60.837 -16.501 23.732  1.00 41.16  ? 131 SER G C   1 
ATOM   4148 O O   . SER C 3 131 ? -61.774 -15.699 23.661  1.00 45.57  ? 131 SER G O   1 
ATOM   4149 C CB  . SER C 3 131 ? -59.120 -15.444 22.245  1.00 45.24  ? 131 SER G CB  1 
ATOM   4150 O OG  . SER C 3 131 ? -58.189 -15.640 21.194  1.00 50.93  ? 131 SER G OG  1 
ATOM   4151 N N   . VAL C 3 132 ? -60.563 -17.210 24.823  1.00 47.33  ? 132 VAL G N   1 
ATOM   4152 C CA  . VAL C 3 132 ? -61.295 -17.061 26.075  1.00 49.46  ? 132 VAL G CA  1 
ATOM   4153 C C   . VAL C 3 132 ? -60.377 -16.349 27.057  1.00 46.29  ? 132 VAL G C   1 
ATOM   4154 O O   . VAL C 3 132 ? -59.266 -16.818 27.333  1.00 43.24  ? 132 VAL G O   1 
ATOM   4155 C CB  . VAL C 3 132 ? -61.760 -18.416 26.627  1.00 44.75  ? 132 VAL G CB  1 
ATOM   4156 C CG1 . VAL C 3 132 ? -62.627 -18.214 27.858  1.00 44.13  ? 132 VAL G CG1 1 
ATOM   4157 C CG2 . VAL C 3 132 ? -62.518 -19.185 25.561  1.00 43.28  ? 132 VAL G CG2 1 
ATOM   4158 N N   . VAL C 3 133 ? -60.837 -15.218 27.583  1.00 45.35  ? 133 VAL G N   1 
ATOM   4159 C CA  . VAL C 3 133 ? -60.038 -14.366 28.453  1.00 40.15  ? 133 VAL G CA  1 
ATOM   4160 C C   . VAL C 3 133 ? -60.614 -14.427 29.859  1.00 47.64  ? 133 VAL G C   1 
ATOM   4161 O O   . VAL C 3 133 ? -61.814 -14.202 30.059  1.00 49.23  ? 133 VAL G O   1 
ATOM   4162 C CB  . VAL C 3 133 ? -59.997 -12.919 27.934  1.00 40.25  ? 133 VAL G CB  1 
ATOM   4163 C CG1 . VAL C 3 133 ? -59.287 -12.015 28.929  1.00 47.68  ? 133 VAL G CG1 1 
ATOM   4164 C CG2 . VAL C 3 133 ? -59.305 -12.876 26.584  1.00 41.69  ? 133 VAL G CG2 1 
ATOM   4165 N N   . CYS C 3 134 ? -59.758 -14.736 30.827  1.00 44.53  ? 134 CYS G N   1 
ATOM   4166 C CA  . CYS C 3 134 ? -60.118 -14.755 32.236  1.00 43.90  ? 134 CYS G CA  1 
ATOM   4167 C C   . CYS C 3 134 ? -59.378 -13.629 32.945  1.00 51.06  ? 134 CYS G C   1 
ATOM   4168 O O   . CYS C 3 134 ? -58.154 -13.515 32.823  1.00 50.14  ? 134 CYS G O   1 
ATOM   4169 C CB  . CYS C 3 134 ? -59.773 -16.104 32.865  1.00 44.29  ? 134 CYS G CB  1 
ATOM   4170 S SG  . CYS C 3 134 ? -60.409 -16.311 34.531  1.00 49.52  ? 134 CYS G SG  1 
ATOM   4171 N N   . LEU C 3 135 ? -60.117 -12.802 33.681  1.00 44.73  ? 135 LEU G N   1 
ATOM   4172 C CA  . LEU C 3 135 ? -59.580 -11.587 34.282  1.00 45.15  ? 135 LEU G CA  1 
ATOM   4173 C C   . LEU C 3 135 ? -59.555 -11.705 35.799  1.00 47.43  ? 135 LEU G C   1 
ATOM   4174 O O   . LEU C 3 135 ? -60.570 -12.040 36.419  1.00 43.18  ? 135 LEU G O   1 
ATOM   4175 C CB  . LEU C 3 135 ? -60.405 -10.364 33.872  1.00 51.42  ? 135 LEU G CB  1 
ATOM   4176 C CG  . LEU C 3 135 ? -60.056 -9.033  34.547  1.00 45.74  ? 135 LEU G CG  1 
ATOM   4177 C CD1 . LEU C 3 135 ? -58.610 -8.650  34.290  1.00 42.32  ? 135 LEU G CD1 1 
ATOM   4178 C CD2 . LEU C 3 135 ? -60.985 -7.932  34.069  1.00 49.74  ? 135 LEU G CD2 1 
ATOM   4179 N N   . LEU C 3 136 ? -58.396 -11.421 36.390  1.00 48.60  ? 136 LEU G N   1 
ATOM   4180 C CA  . LEU C 3 136 ? -58.241 -11.284 37.835  1.00 48.85  ? 136 LEU G CA  1 
ATOM   4181 C C   . LEU C 3 136 ? -57.912 -9.822  38.107  1.00 52.16  ? 136 LEU G C   1 
ATOM   4182 O O   . LEU C 3 136 ? -56.844 -9.339  37.715  1.00 57.08  ? 136 LEU G O   1 
ATOM   4183 C CB  . LEU C 3 136 ? -57.147 -12.207 38.371  1.00 45.09  ? 136 LEU G CB  1 
ATOM   4184 C CG  . LEU C 3 136 ? -57.380 -13.717 38.506  1.00 38.42  ? 136 LEU G CG  1 
ATOM   4185 C CD1 . LEU C 3 136 ? -57.588 -14.401 37.161  1.00 41.35  ? 136 LEU G CD1 1 
ATOM   4186 C CD2 . LEU C 3 136 ? -56.209 -14.352 39.240  1.00 38.23  ? 136 LEU G CD2 1 
ATOM   4187 N N   . ASN C 3 137 ? -58.824 -9.116  38.770  1.00 51.37  ? 137 ASN G N   1 
ATOM   4188 C CA  . ASN C 3 137 ? -58.745 -7.668  38.895  1.00 55.57  ? 137 ASN G CA  1 
ATOM   4189 C C   . ASN C 3 137 ? -58.542 -7.269  40.350  1.00 54.22  ? 137 ASN G C   1 
ATOM   4190 O O   . ASN C 3 137 ? -59.279 -7.727  41.231  1.00 55.57  ? 137 ASN G O   1 
ATOM   4191 C CB  . ASN C 3 137 ? -60.011 -7.011  38.338  1.00 54.92  ? 137 ASN G CB  1 
ATOM   4192 C CG  . ASN C 3 137 ? -59.785 -5.572  37.929  1.00 61.58  ? 137 ASN G CG  1 
ATOM   4193 O OD1 . ASN C 3 137 ? -58.678 -5.190  37.551  1.00 62.19  ? 137 ASN G OD1 1 
ATOM   4194 N ND2 . ASN C 3 137 ? -60.835 -4.762  38.005  1.00 56.98  ? 137 ASN G ND2 1 
ATOM   4195 N N   . ASN C 3 138 ? -57.540 -6.419  40.592  1.00 55.77  ? 138 ASN G N   1 
ATOM   4196 C CA  . ASN C 3 138 ? -57.332 -5.733  41.870  1.00 60.62  ? 138 ASN G CA  1 
ATOM   4197 C C   . ASN C 3 138 ? -57.140 -6.727  43.021  1.00 55.54  ? 138 ASN G C   1 
ATOM   4198 O O   . ASN C 3 138 ? -57.954 -6.828  43.940  1.00 61.77  ? 138 ASN G O   1 
ATOM   4199 C CB  . ASN C 3 138 ? -58.491 -4.773  42.167  1.00 61.92  ? 138 ASN G CB  1 
ATOM   4200 C CG  . ASN C 3 138 ? -58.656 -3.704  41.100  1.00 58.47  ? 138 ASN G CG  1 
ATOM   4201 O OD1 . ASN C 3 138 ? -57.705 -3.351  40.400  1.00 57.87  ? 138 ASN G OD1 1 
ATOM   4202 N ND2 . ASN C 3 138 ? -59.868 -3.177  40.978  1.00 50.42  ? 138 ASN G ND2 1 
ATOM   4203 N N   . PHE C 3 139 ? -56.029 -7.460  42.948  1.00 59.79  ? 139 PHE G N   1 
ATOM   4204 C CA  . PHE C 3 139 ? -55.692 -8.443  43.967  1.00 60.63  ? 139 PHE G CA  1 
ATOM   4205 C C   . PHE C 3 139 ? -54.282 -8.213  44.493  1.00 59.06  ? 139 PHE G C   1 
ATOM   4206 O O   . PHE C 3 139 ? -53.414 -7.684  43.793  1.00 53.34  ? 139 PHE G O   1 
ATOM   4207 C CB  . PHE C 3 139 ? -55.823 -9.887  43.439  1.00 52.37  ? 139 PHE G CB  1 
ATOM   4208 C CG  . PHE C 3 139 ? -54.876 -10.224 42.316  1.00 46.17  ? 139 PHE G CG  1 
ATOM   4209 C CD1 . PHE C 3 139 ? -55.204 -9.933  41.001  1.00 47.64  ? 139 PHE G CD1 1 
ATOM   4210 C CD2 . PHE C 3 139 ? -53.668 -10.856 42.575  1.00 49.94  ? 139 PHE G CD2 1 
ATOM   4211 C CE1 . PHE C 3 139 ? -54.337 -10.249 39.966  1.00 49.39  ? 139 PHE G CE1 1 
ATOM   4212 C CE2 . PHE C 3 139 ? -52.798 -11.175 41.545  1.00 49.23  ? 139 PHE G CE2 1 
ATOM   4213 C CZ  . PHE C 3 139 ? -53.133 -10.871 40.240  1.00 48.68  ? 139 PHE G CZ  1 
ATOM   4214 N N   . TYR C 3 140 ? -54.071 -8.616  45.747  1.00 62.79  ? 140 TYR G N   1 
ATOM   4215 C CA  . TYR C 3 140 ? -52.780 -8.589  46.407  1.00 58.69  ? 140 TYR G CA  1 
ATOM   4216 C C   . TYR C 3 140 ? -52.759 -9.788  47.343  1.00 58.74  ? 140 TYR G C   1 
ATOM   4217 O O   . TYR C 3 140 ? -53.772 -10.057 48.005  1.00 52.14  ? 140 TYR G O   1 
ATOM   4218 C CB  . TYR C 3 140 ? -52.545 -7.292  47.191  1.00 62.05  ? 140 TYR G CB  1 
ATOM   4219 C CG  . TYR C 3 140 ? -51.124 -7.137  47.671  1.00 64.07  ? 140 TYR G CG  1 
ATOM   4220 C CD1 . TYR C 3 140 ? -50.724 -7.664  48.891  1.00 67.16  ? 140 TYR G CD1 1 
ATOM   4221 C CD2 . TYR C 3 140 ? -50.175 -6.483  46.896  1.00 69.95  ? 140 TYR G CD2 1 
ATOM   4222 C CE1 . TYR C 3 140 ? -49.423 -7.541  49.329  1.00 67.73  ? 140 TYR G CE1 1 
ATOM   4223 C CE2 . TYR C 3 140 ? -48.869 -6.352  47.328  1.00 76.09  ? 140 TYR G CE2 1 
ATOM   4224 C CZ  . TYR C 3 140 ? -48.500 -6.884  48.546  1.00 70.40  ? 140 TYR G CZ  1 
ATOM   4225 O OH  . TYR C 3 140 ? -47.204 -6.762  48.989  1.00 79.77  ? 140 TYR G OH  1 
ATOM   4226 N N   . PRO C 3 141 ? -51.639 -10.531 47.425  1.00 56.49  ? 141 PRO G N   1 
ATOM   4227 C CA  . PRO C 3 141 ? -50.343 -10.321 46.760  1.00 49.65  ? 141 PRO G CA  1 
ATOM   4228 C C   . PRO C 3 141 ? -50.326 -10.721 45.287  1.00 57.50  ? 141 PRO G C   1 
ATOM   4229 O O   . PRO C 3 141 ? -51.344 -11.087 44.707  1.00 59.54  ? 141 PRO G O   1 
ATOM   4230 C CB  . PRO C 3 141 ? -49.400 -11.198 47.589  1.00 46.31  ? 141 PRO G CB  1 
ATOM   4231 C CG  . PRO C 3 141 ? -50.263 -12.348 48.002  1.00 42.85  ? 141 PRO G CG  1 
ATOM   4232 C CD  . PRO C 3 141 ? -51.612 -11.731 48.283  1.00 54.26  ? 141 PRO G CD  1 
ATOM   4233 N N   . ARG C 3 142 ? -49.147 -10.653 44.665  1.00 56.79  ? 142 ARG G N   1 
ATOM   4234 C CA  . ARG C 3 142 ? -49.035 -10.924 43.236  1.00 54.98  ? 142 ARG G CA  1 
ATOM   4235 C C   . ARG C 3 142 ? -49.194 -12.408 42.920  1.00 48.95  ? 142 ARG G C   1 
ATOM   4236 O O   . ARG C 3 142 ? -49.642 -12.760 41.822  1.00 47.23  ? 142 ARG G O   1 
ATOM   4237 C CB  . ARG C 3 142 ? -47.692 -10.405 42.722  1.00 45.66  ? 142 ARG G CB  1 
ATOM   4238 C CG  . ARG C 3 142 ? -47.492 -10.507 41.224  1.00 40.01  ? 142 ARG G CG  1 
ATOM   4239 C CD  . ARG C 3 142 ? -46.103 -10.030 40.844  1.00 45.79  ? 142 ARG G CD  1 
ATOM   4240 N NE  . ARG C 3 142 ? -45.424 -10.994 39.988  1.00 50.60  ? 142 ARG G NE  1 
ATOM   4241 C CZ  . ARG C 3 142 ? -45.437 -10.956 38.663  1.00 56.95  ? 142 ARG G CZ  1 
ATOM   4242 N NH1 . ARG C 3 142 ? -46.063 -9.993  38.006  1.00 61.97  ? 142 ARG G NH1 1 
ATOM   4243 N NH2 . ARG C 3 142 ? -44.808 -11.907 37.980  1.00 73.63  ? 142 ARG G NH2 1 
ATOM   4244 N N   . GLU C 3 143 ? -48.841 -13.287 43.856  1.00 56.93  ? 143 GLU G N   1 
ATOM   4245 C CA  . GLU C 3 143 ? -48.869 -14.721 43.590  1.00 69.12  ? 143 GLU G CA  1 
ATOM   4246 C C   . GLU C 3 143 ? -50.304 -15.200 43.409  1.00 59.31  ? 143 GLU G C   1 
ATOM   4247 O O   . GLU C 3 143 ? -51.151 -15.010 44.289  1.00 60.36  ? 143 GLU G O   1 
ATOM   4248 C CB  . GLU C 3 143 ? -48.182 -15.486 44.722  1.00 71.16  ? 143 GLU G CB  1 
ATOM   4249 C CG  . GLU C 3 143 ? -48.546 -16.971 44.810  1.00 80.62  ? 143 GLU G CG  1 
ATOM   4250 C CD  . GLU C 3 143 ? -48.036 -17.808 43.642  1.00 91.89  ? 143 GLU G CD  1 
ATOM   4251 O OE1 . GLU C 3 143 ? -47.264 -17.291 42.805  1.00 98.52  ? 143 GLU G OE1 1 
ATOM   4252 O OE2 . GLU C 3 143 ? -48.410 -18.998 43.568  1.00 82.11  ? 143 GLU G OE2 1 
ATOM   4253 N N   . ALA C 3 144 ? -50.574 -15.823 42.265  1.00 52.57  ? 144 ALA G N   1 
ATOM   4254 C CA  . ALA C 3 144 ? -51.897 -16.349 41.974  1.00 48.68  ? 144 ALA G CA  1 
ATOM   4255 C C   . ALA C 3 144 ? -51.756 -17.541 41.041  1.00 44.82  ? 144 ALA G C   1 
ATOM   4256 O O   . ALA C 3 144 ? -50.771 -17.671 40.308  1.00 37.50  ? 144 ALA G O   1 
ATOM   4257 C CB  . ALA C 3 144 ? -52.807 -15.279 41.359  1.00 42.46  ? 144 ALA G CB  1 
ATOM   4258 N N   . LYS C 3 145 ? -52.755 -18.417 41.083  1.00 54.01  ? 145 LYS G N   1 
ATOM   4259 C CA  . LYS C 3 145 ? -52.778 -19.629 40.275  1.00 49.40  ? 145 LYS G CA  1 
ATOM   4260 C C   . LYS C 3 145 ? -54.081 -19.657 39.494  1.00 51.25  ? 145 LYS G C   1 
ATOM   4261 O O   . LYS C 3 145 ? -55.162 -19.575 40.086  1.00 55.26  ? 145 LYS G O   1 
ATOM   4262 C CB  . LYS C 3 145 ? -52.639 -20.877 41.152  1.00 45.01  ? 145 LYS G CB  1 
ATOM   4263 C CG  . LYS C 3 145 ? -52.523 -22.182 40.384  1.00 47.50  ? 145 LYS G CG  1 
ATOM   4264 C CD  . LYS C 3 145 ? -52.470 -23.370 41.336  1.00 60.79  ? 145 LYS G CD  1 
ATOM   4265 C CE  . LYS C 3 145 ? -52.345 -24.687 40.587  1.00 54.82  ? 145 LYS G CE  1 
ATOM   4266 N NZ  . LYS C 3 145 ? -52.404 -25.850 41.516  1.00 60.08  ? 145 LYS G NZ  1 
ATOM   4267 N N   . VAL C 3 146 ? -53.981 -19.763 38.172  1.00 45.75  ? 146 VAL G N   1 
ATOM   4268 C CA  . VAL C 3 146 ? -55.141 -19.805 37.290  1.00 44.49  ? 146 VAL G CA  1 
ATOM   4269 C C   . VAL C 3 146 ? -55.071 -21.081 36.466  1.00 41.62  ? 146 VAL G C   1 
ATOM   4270 O O   . VAL C 3 146 ? -54.062 -21.342 35.801  1.00 50.13  ? 146 VAL G O   1 
ATOM   4271 C CB  . VAL C 3 146 ? -55.209 -18.571 36.374  1.00 53.20  ? 146 VAL G CB  1 
ATOM   4272 C CG1 . VAL C 3 146 ? -56.377 -18.695 35.410  1.00 50.45  ? 146 VAL G CG1 1 
ATOM   4273 C CG2 . VAL C 3 146 ? -55.333 -17.306 37.203  1.00 46.73  ? 146 VAL G CG2 1 
ATOM   4274 N N   . GLN C 3 147 ? -56.142 -21.865 36.502  1.00 40.62  ? 147 GLN G N   1 
ATOM   4275 C CA  . GLN C 3 147 ? -56.214 -23.121 35.773  1.00 42.05  ? 147 GLN G CA  1 
ATOM   4276 C C   . GLN C 3 147 ? -57.388 -23.084 34.808  1.00 40.02  ? 147 GLN G C   1 
ATOM   4277 O O   . GLN C 3 147 ? -58.426 -22.482 35.101  1.00 41.03  ? 147 GLN G O   1 
ATOM   4278 C CB  . GLN C 3 147 ? -56.356 -24.306 36.729  1.00 42.93  ? 147 GLN G CB  1 
ATOM   4279 C CG  . GLN C 3 147 ? -55.195 -24.461 37.695  1.00 54.40  ? 147 GLN G CG  1 
ATOM   4280 C CD  . GLN C 3 147 ? -55.420 -25.573 38.695  1.00 59.10  ? 147 GLN G CD  1 
ATOM   4281 O OE1 . GLN C 3 147 ? -56.197 -25.426 39.639  1.00 54.17  ? 147 GLN G OE1 1 
ATOM   4282 N NE2 . GLN C 3 147 ? -54.744 -26.698 38.491  1.00 64.72  ? 147 GLN G NE2 1 
ATOM   4283 N N   . TRP C 3 148 ? -57.211 -23.718 33.653  1.00 39.92  ? 148 TRP G N   1 
ATOM   4284 C CA  . TRP C 3 148 ? -58.254 -23.825 32.639  1.00 38.20  ? 148 TRP G CA  1 
ATOM   4285 C C   . TRP C 3 148 ? -58.767 -25.259 32.623  1.00 41.22  ? 148 TRP G C   1 
ATOM   4286 O O   . TRP C 3 148 ? -58.031 -26.184 32.262  1.00 39.92  ? 148 TRP G O   1 
ATOM   4287 C CB  . TRP C 3 148 ? -57.731 -23.418 31.264  1.00 31.24  ? 148 TRP G CB  1 
ATOM   4288 C CG  . TRP C 3 148 ? -57.591 -21.945 31.090  1.00 37.73  ? 148 TRP G CG  1 
ATOM   4289 C CD1 . TRP C 3 148 ? -56.435 -21.222 31.119  1.00 39.81  ? 148 TRP G CD1 1 
ATOM   4290 C CD2 . TRP C 3 148 ? -58.647 -21.005 30.860  1.00 47.99  ? 148 TRP G CD2 1 
ATOM   4291 N NE1 . TRP C 3 148 ? -56.705 -19.891 30.919  1.00 36.27  ? 148 TRP G NE1 1 
ATOM   4292 C CE2 . TRP C 3 148 ? -58.056 -19.730 30.758  1.00 43.30  ? 148 TRP G CE2 1 
ATOM   4293 C CE3 . TRP C 3 148 ? -60.036 -21.117 30.730  1.00 45.82  ? 148 TRP G CE3 1 
ATOM   4294 C CZ2 . TRP C 3 148 ? -58.804 -18.577 30.531  1.00 52.03  ? 148 TRP G CZ2 1 
ATOM   4295 C CZ3 . TRP C 3 148 ? -60.776 -19.970 30.505  1.00 46.18  ? 148 TRP G CZ3 1 
ATOM   4296 C CH2 . TRP C 3 148 ? -60.159 -18.717 30.409  1.00 48.42  ? 148 TRP G CH2 1 
ATOM   4297 N N   . LYS C 3 149 ? -60.027 -25.438 33.012  1.00 45.87  ? 149 LYS G N   1 
ATOM   4298 C CA  . LYS C 3 149 ? -60.701 -26.731 32.958  1.00 48.25  ? 149 LYS G CA  1 
ATOM   4299 C C   . LYS C 3 149 ? -61.811 -26.641 31.917  1.00 50.34  ? 149 LYS G C   1 
ATOM   4300 O O   . LYS C 3 149 ? -62.786 -25.904 32.100  1.00 52.62  ? 149 LYS G O   1 
ATOM   4301 C CB  . LYS C 3 149 ? -61.252 -27.127 34.327  1.00 40.75  ? 149 LYS G CB  1 
ATOM   4302 C CG  . LYS C 3 149 ? -60.184 -27.319 35.398  1.00 49.40  ? 149 LYS G CG  1 
ATOM   4303 C CD  . LYS C 3 149 ? -60.764 -27.897 36.684  1.00 48.90  ? 149 LYS G CD  1 
ATOM   4304 C CE  . LYS C 3 149 ? -61.299 -29.305 36.464  1.00 63.03  ? 149 LYS G CE  1 
ATOM   4305 N NZ  . LYS C 3 149 ? -61.879 -29.895 37.704  1.00 60.21  ? 149 LYS G NZ  1 
ATOM   4306 N N   . VAL C 3 150 ? -61.659 -27.391 30.829  1.00 46.44  ? 150 VAL G N   1 
ATOM   4307 C CA  . VAL C 3 150 ? -62.639 -27.451 29.751  1.00 40.13  ? 150 VAL G CA  1 
ATOM   4308 C C   . VAL C 3 150 ? -63.352 -28.793 29.840  1.00 47.38  ? 150 VAL G C   1 
ATOM   4309 O O   . VAL C 3 150 ? -62.733 -29.846 29.641  1.00 46.44  ? 150 VAL G O   1 
ATOM   4310 C CB  . VAL C 3 150 ? -61.978 -27.271 28.378  1.00 41.35  ? 150 VAL G CB  1 
ATOM   4311 C CG1 . VAL C 3 150 ? -62.983 -27.519 27.279  1.00 41.96  ? 150 VAL G CG1 1 
ATOM   4312 C CG2 . VAL C 3 150 ? -61.384 -25.876 28.257  1.00 49.11  ? 150 VAL G CG2 1 
ATOM   4313 N N   . ASP C 3 151 ? -64.657 -28.751 30.118  1.00 44.34  ? 151 ASP G N   1 
ATOM   4314 C CA  . ASP C 3 151 ? -65.446 -29.954 30.383  1.00 43.24  ? 151 ASP G CA  1 
ATOM   4315 C C   . ASP C 3 151 ? -64.809 -30.780 31.501  1.00 52.02  ? 151 ASP G C   1 
ATOM   4316 O O   . ASP C 3 151 ? -64.690 -32.004 31.411  1.00 54.14  ? 151 ASP G O   1 
ATOM   4317 C CB  . ASP C 3 151 ? -65.636 -30.789 29.111  1.00 39.73  ? 151 ASP G CB  1 
ATOM   4318 C CG  . ASP C 3 151 ? -66.517 -30.097 28.075  1.00 42.63  ? 151 ASP G CG  1 
ATOM   4319 O OD1 . ASP C 3 151 ? -67.407 -29.314 28.467  1.00 37.02  ? 151 ASP G OD1 1 
ATOM   4320 O OD2 . ASP C 3 151 ? -66.323 -30.342 26.864  1.00 46.89  ? 151 ASP G OD2 1 
ATOM   4321 N N   . ASN C 3 152 ? -64.387 -30.088 32.565  1.00 54.04  ? 152 ASN G N   1 
ATOM   4322 C CA  . ASN C 3 152 ? -63.728 -30.699 33.725  1.00 50.44  ? 152 ASN G CA  1 
ATOM   4323 C C   . ASN C 3 152 ? -62.433 -31.409 33.342  1.00 51.21  ? 152 ASN G C   1 
ATOM   4324 O O   . ASN C 3 152 ? -62.029 -32.377 33.993  1.00 54.46  ? 152 ASN G O   1 
ATOM   4325 C CB  . ASN C 3 152 ? -64.661 -31.665 34.463  1.00 40.45  ? 152 ASN G CB  1 
ATOM   4326 C CG  . ASN C 3 152 ? -65.266 -31.052 35.708  1.00 58.54  ? 152 ASN G CG  1 
ATOM   4327 O OD1 . ASN C 3 152 ? -64.609 -30.949 36.745  1.00 63.56  ? 152 ASN G OD1 1 
ATOM   4328 N ND2 . ASN C 3 152 ? -66.527 -30.647 35.615  1.00 56.79  ? 152 ASN G ND2 1 
ATOM   4329 N N   . ALA C 3 153 ? -61.773 -30.936 32.287  1.00 40.13  ? 153 ALA G N   1 
ATOM   4330 C CA  . ALA C 3 153 ? -60.491 -31.474 31.848  1.00 41.56  ? 153 ALA G CA  1 
ATOM   4331 C C   . ALA C 3 153 ? -59.465 -30.352 31.869  1.00 45.04  ? 153 ALA G C   1 
ATOM   4332 O O   . ALA C 3 153 ? -59.645 -29.330 31.197  1.00 53.10  ? 153 ALA G O   1 
ATOM   4333 C CB  . ALA C 3 153 ? -60.594 -32.086 30.449  1.00 42.68  ? 153 ALA G CB  1 
ATOM   4334 N N   . LEU C 3 154 ? -58.390 -30.547 32.627  1.00 38.18  ? 154 LEU G N   1 
ATOM   4335 C CA  . LEU C 3 154 ? -57.380 -29.509 32.778  1.00 34.33  ? 154 LEU G CA  1 
ATOM   4336 C C   . LEU C 3 154 ? -56.656 -29.277 31.457  1.00 41.48  ? 154 LEU G C   1 
ATOM   4337 O O   . LEU C 3 154 ? -56.249 -30.228 30.783  1.00 38.94  ? 154 LEU G O   1 
ATOM   4338 C CB  . LEU C 3 154 ? -56.384 -29.901 33.867  1.00 31.87  ? 154 LEU G CB  1 
ATOM   4339 C CG  . LEU C 3 154 ? -55.494 -28.775 34.392  1.00 48.62  ? 154 LEU G CG  1 
ATOM   4340 C CD1 . LEU C 3 154 ? -56.316 -27.795 35.218  1.00 41.24  ? 154 LEU G CD1 1 
ATOM   4341 C CD2 . LEU C 3 154 ? -54.323 -29.330 35.196  1.00 38.84  ? 154 LEU G CD2 1 
ATOM   4342 N N   . GLN C 3 155 ? -56.490 -28.009 31.092  1.00 46.10  ? 155 GLN G N   1 
ATOM   4343 C CA  . GLN C 3 155 ? -55.822 -27.633 29.855  1.00 38.77  ? 155 GLN G CA  1 
ATOM   4344 C C   . GLN C 3 155 ? -54.380 -27.239 30.126  1.00 40.90  ? 155 GLN G C   1 
ATOM   4345 O O   . GLN C 3 155 ? -54.056 -26.675 31.175  1.00 54.31  ? 155 GLN G O   1 
ATOM   4346 C CB  . GLN C 3 155 ? -56.542 -26.471 29.172  1.00 45.71  ? 155 GLN G CB  1 
ATOM   4347 C CG  . GLN C 3 155 ? -57.926 -26.813 28.686  1.00 41.33  ? 155 GLN G CG  1 
ATOM   4348 C CD  . GLN C 3 155 ? -57.904 -27.754 27.504  1.00 47.64  ? 155 GLN G CD  1 
ATOM   4349 O OE1 . GLN C 3 155 ? -56.882 -27.909 26.838  1.00 47.20  ? 155 GLN G OE1 1 
ATOM   4350 N NE2 . GLN C 3 155 ? -59.037 -28.387 27.234  1.00 59.70  ? 155 GLN G NE2 1 
ATOM   4351 N N   . SER C 3 156 ? -53.516 -27.532 29.157  1.00 38.47  ? 156 SER G N   1 
ATOM   4352 C CA  . SER C 3 156 ? -52.106 -27.190 29.251  1.00 38.01  ? 156 SER G CA  1 
ATOM   4353 C C   . SER C 3 156 ? -51.572 -26.891 27.860  1.00 42.85  ? 156 SER G C   1 
ATOM   4354 O O   . SER C 3 156 ? -51.943 -27.557 26.888  1.00 43.80  ? 156 SER G O   1 
ATOM   4355 C CB  . SER C 3 156 ? -51.297 -28.320 29.896  1.00 38.57  ? 156 SER G CB  1 
ATOM   4356 O OG  . SER C 3 156 ? -51.739 -28.567 31.220  1.00 52.87  ? 156 SER G OG  1 
ATOM   4357 N N   . GLY C 3 157 ? -50.699 -25.887 27.775  1.00 36.73  ? 157 GLY G N   1 
ATOM   4358 C CA  . GLY C 3 157 ? -50.023 -25.553 26.541  1.00 44.47  ? 157 GLY G CA  1 
ATOM   4359 C C   . GLY C 3 157 ? -50.795 -24.670 25.590  1.00 43.97  ? 157 GLY G C   1 
ATOM   4360 O O   . GLY C 3 157 ? -50.323 -24.434 24.471  1.00 55.86  ? 157 GLY G O   1 
ATOM   4361 N N   . ASN C 3 158 ? -51.964 -24.173 25.990  1.00 48.63  ? 158 ASN G N   1 
ATOM   4362 C CA  . ASN C 3 158 ? -52.778 -23.318 25.135  1.00 45.54  ? 158 ASN G CA  1 
ATOM   4363 C C   . ASN C 3 158 ? -53.271 -22.091 25.893  1.00 51.29  ? 158 ASN G C   1 
ATOM   4364 O O   . ASN C 3 158 ? -54.308 -21.517 25.548  1.00 51.87  ? 158 ASN G O   1 
ATOM   4365 C CB  . ASN C 3 158 ? -53.955 -24.095 24.547  1.00 48.89  ? 158 ASN G CB  1 
ATOM   4366 C CG  . ASN C 3 158 ? -54.734 -24.864 25.599  1.00 49.65  ? 158 ASN G CG  1 
ATOM   4367 O OD1 . ASN C 3 158 ? -54.395 -24.838 26.784  1.00 47.01  ? 158 ASN G OD1 1 
ATOM   4368 N ND2 . ASN C 3 158 ? -55.788 -25.546 25.172  1.00 55.15  ? 158 ASN G ND2 1 
ATOM   4369 N N   . SER C 3 159 ? -52.543 -21.672 26.925  1.00 52.78  ? 159 SER G N   1 
ATOM   4370 C CA  . SER C 3 159 ? -52.904 -20.483 27.681  1.00 48.16  ? 159 SER G CA  1 
ATOM   4371 C C   . SER C 3 159 ? -51.659 -19.651 27.944  1.00 44.15  ? 159 SER G C   1 
ATOM   4372 O O   . SER C 3 159 ? -50.553 -20.182 28.070  1.00 50.40  ? 159 SER G O   1 
ATOM   4373 C CB  . SER C 3 159 ? -53.583 -20.841 29.006  1.00 44.89  ? 159 SER G CB  1 
ATOM   4374 O OG  . SER C 3 159 ? -52.701 -21.570 29.840  1.00 71.28  ? 159 SER G OG  1 
ATOM   4375 N N   . GLN C 3 160 ? -51.854 -18.335 28.024  1.00 42.42  ? 160 GLN G N   1 
ATOM   4376 C CA  . GLN C 3 160 ? -50.791 -17.394 28.349  1.00 41.57  ? 160 GLN G CA  1 
ATOM   4377 C C   . GLN C 3 160 ? -51.317 -16.377 29.352  1.00 41.11  ? 160 GLN G C   1 
ATOM   4378 O O   . GLN C 3 160 ? -52.509 -16.060 29.368  1.00 47.61  ? 160 GLN G O   1 
ATOM   4379 C CB  . GLN C 3 160 ? -50.256 -16.687 27.095  1.00 32.94  ? 160 GLN G CB  1 
ATOM   4380 C CG  . GLN C 3 160 ? -49.442 -17.591 26.184  1.00 42.94  ? 160 GLN G CG  1 
ATOM   4381 C CD  . GLN C 3 160 ? -48.920 -16.874 24.955  1.00 51.08  ? 160 GLN G CD  1 
ATOM   4382 O OE1 . GLN C 3 160 ? -47.879 -17.236 24.407  1.00 62.85  ? 160 GLN G OE1 1 
ATOM   4383 N NE2 . GLN C 3 160 ? -49.645 -15.853 24.513  1.00 53.95  ? 160 GLN G NE2 1 
ATOM   4384 N N   . GLU C 3 161 ? -50.417 -15.864 30.190  1.00 36.78  ? 161 GLU G N   1 
ATOM   4385 C CA  . GLU C 3 161 ? -50.798 -14.972 31.274  1.00 40.42  ? 161 GLU G CA  1 
ATOM   4386 C C   . GLU C 3 161 ? -49.999 -13.680 31.197  1.00 45.34  ? 161 GLU G C   1 
ATOM   4387 O O   . GLU C 3 161 ? -48.848 -13.665 30.755  1.00 40.07  ? 161 GLU G O   1 
ATOM   4388 C CB  . GLU C 3 161 ? -50.592 -15.636 32.640  1.00 38.28  ? 161 GLU G CB  1 
ATOM   4389 C CG  . GLU C 3 161 ? -51.130 -17.054 32.692  1.00 60.09  ? 161 GLU G CG  1 
ATOM   4390 C CD  . GLU C 3 161 ? -51.869 -17.357 33.974  1.00 71.95  ? 161 GLU G CD  1 
ATOM   4391 O OE1 . GLU C 3 161 ? -51.412 -16.904 35.045  1.00 65.16  ? 161 GLU G OE1 1 
ATOM   4392 O OE2 . GLU C 3 161 ? -52.911 -18.044 33.909  1.00 73.88  ? 161 GLU G OE2 1 
ATOM   4393 N N   . SER C 3 162 ? -50.632 -12.592 31.627  1.00 47.96  ? 162 SER G N   1 
ATOM   4394 C CA  . SER C 3 162 ? -50.009 -11.278 31.645  1.00 38.73  ? 162 SER G CA  1 
ATOM   4395 C C   . SER C 3 162 ? -50.401 -10.579 32.936  1.00 41.16  ? 162 SER G C   1 
ATOM   4396 O O   . SER C 3 162 ? -51.556 -10.663 33.367  1.00 41.81  ? 162 SER G O   1 
ATOM   4397 C CB  . SER C 3 162 ? -50.427 -10.447 30.424  1.00 44.60  ? 162 SER G CB  1 
ATOM   4398 O OG  . SER C 3 162 ? -49.733 -9.213  30.371  1.00 46.42  ? 162 SER G OG  1 
ATOM   4399 N N   . VAL C 3 163 ? -49.435 -9.909  33.560  1.00 38.78  ? 163 VAL G N   1 
ATOM   4400 C CA  . VAL C 3 163 ? -49.625 -9.259  34.852  1.00 42.02  ? 163 VAL G CA  1 
ATOM   4401 C C   . VAL C 3 163 ? -49.259 -7.789  34.714  1.00 52.09  ? 163 VAL G C   1 
ATOM   4402 O O   . VAL C 3 163 ? -48.214 -7.454  34.143  1.00 54.96  ? 163 VAL G O   1 
ATOM   4403 C CB  . VAL C 3 163 ? -48.781 -9.917  35.960  1.00 37.98  ? 163 VAL G CB  1 
ATOM   4404 C CG1 . VAL C 3 163 ? -49.308 -9.513  37.324  1.00 45.37  ? 163 VAL G CG1 1 
ATOM   4405 C CG2 . VAL C 3 163 ? -48.765 -11.432 35.811  1.00 44.22  ? 163 VAL G CG2 1 
ATOM   4406 N N   . THR C 3 164 ? -50.114 -6.917  35.242  1.00 52.60  ? 164 THR G N   1 
ATOM   4407 C CA  . THR C 3 164 ? -49.838 -5.490  35.232  1.00 55.43  ? 164 THR G CA  1 
ATOM   4408 C C   . THR C 3 164 ? -48.879 -5.118  36.360  1.00 51.25  ? 164 THR G C   1 
ATOM   4409 O O   . THR C 3 164 ? -48.584 -5.911  37.257  1.00 54.90  ? 164 THR G O   1 
ATOM   4410 C CB  . THR C 3 164 ? -51.126 -4.681  35.372  1.00 45.54  ? 164 THR G CB  1 
ATOM   4411 O OG1 . THR C 3 164 ? -51.820 -5.084  36.560  1.00 44.20  ? 164 THR G OG1 1 
ATOM   4412 C CG2 . THR C 3 164 ? -52.023 -4.881  34.161  1.00 53.20  ? 164 THR G CG2 1 
ATOM   4413 N N   . GLU C 3 165 ? -48.391 -3.885  36.301  1.00 60.66  ? 165 GLU G N   1 
ATOM   4414 C CA  . GLU C 3 165 ? -47.592 -3.343  37.383  1.00 61.06  ? 165 GLU G CA  1 
ATOM   4415 C C   . GLU C 3 165 ? -48.500 -2.934  38.540  1.00 61.67  ? 165 GLU G C   1 
ATOM   4416 O O   . GLU C 3 165 ? -49.731 -2.955  38.442  1.00 52.55  ? 165 GLU G O   1 
ATOM   4417 C CB  . GLU C 3 165 ? -46.762 -2.155  36.897  1.00 71.88  ? 165 GLU G CB  1 
ATOM   4418 C CG  . GLU C 3 165 ? -45.907 -2.444  35.663  1.00 84.24  ? 165 GLU G CG  1 
ATOM   4419 C CD  . GLU C 3 165 ? -44.822 -3.481  35.913  1.00 89.41  ? 165 GLU G CD  1 
ATOM   4420 O OE1 . GLU C 3 165 ? -44.334 -3.579  37.059  1.00 89.31  ? 165 GLU G OE1 1 
ATOM   4421 O OE2 . GLU C 3 165 ? -44.457 -4.200  34.958  1.00 92.82  ? 165 GLU G OE2 1 
ATOM   4422 N N   . GLN C 3 166 ? -47.878 -2.568  39.654  1.00 63.58  ? 166 GLN G N   1 
ATOM   4423 C CA  . GLN C 3 166 ? -48.644 -2.151  40.816  1.00 56.03  ? 166 GLN G CA  1 
ATOM   4424 C C   . GLN C 3 166 ? -49.413 -0.871  40.525  1.00 69.06  ? 166 GLN G C   1 
ATOM   4425 O O   . GLN C 3 166 ? -48.888 0.069   39.922  1.00 68.50  ? 166 GLN G O   1 
ATOM   4426 C CB  . GLN C 3 166 ? -47.721 -1.945  42.007  1.00 69.21  ? 166 GLN G CB  1 
ATOM   4427 C CG  . GLN C 3 166 ? -47.269 -3.229  42.625  1.00 74.61  ? 166 GLN G CG  1 
ATOM   4428 C CD  . GLN C 3 166 ? -47.251 -3.147  44.126  1.00 80.65  ? 166 GLN G CD  1 
ATOM   4429 O OE1 . GLN C 3 166 ? -48.248 -3.441  44.783  1.00 78.12  ? 166 GLN G OE1 1 
ATOM   4430 N NE2 . GLN C 3 166 ? -46.119 -2.728  44.684  1.00 74.40  ? 166 GLN G NE2 1 
ATOM   4431 N N   . ASP C 3 167 ? -50.668 -0.843  40.959  1.00 74.25  ? 167 ASP G N   1 
ATOM   4432 C CA  . ASP C 3 167 ? -51.504 0.326   40.747  1.00 74.55  ? 167 ASP G CA  1 
ATOM   4433 C C   . ASP C 3 167 ? -51.012 1.496   41.593  1.00 79.00  ? 167 ASP G C   1 
ATOM   4434 O O   . ASP C 3 167 ? -50.396 1.318   42.647  1.00 85.27  ? 167 ASP G O   1 
ATOM   4435 C CB  . ASP C 3 167 ? -52.958 0.001   41.081  1.00 77.27  ? 167 ASP G CB  1 
ATOM   4436 C CG  . ASP C 3 167 ? -53.916 1.078   40.619  1.00 83.25  ? 167 ASP G CG  1 
ATOM   4437 O OD1 . ASP C 3 167 ? -53.761 2.241   41.045  1.00 82.97  ? 167 ASP G OD1 1 
ATOM   4438 O OD2 . ASP C 3 167 ? -54.819 0.762   39.817  1.00 87.81  ? 167 ASP G OD2 1 
ATOM   4439 N N   . SER C 3 168 ? -51.289 2.706   41.112  1.00 85.94  ? 168 SER G N   1 
ATOM   4440 C CA  . SER C 3 168 ? -50.875 3.928   41.789  1.00 92.17  ? 168 SER G CA  1 
ATOM   4441 C C   . SER C 3 168 ? -51.923 4.463   42.757  1.00 82.88  ? 168 SER G C   1 
ATOM   4442 O O   . SER C 3 168 ? -51.676 5.483   43.408  1.00 83.78  ? 168 SER G O   1 
ATOM   4443 C CB  . SER C 3 168 ? -50.535 5.009   40.760  1.00 85.70  ? 168 SER G CB  1 
ATOM   4444 O OG  . SER C 3 168 ? -49.481 4.588   39.913  1.00 85.90  ? 168 SER G OG  1 
ATOM   4445 N N   . LYS C 3 169 ? -53.080 3.808   42.867  1.00 89.51  ? 169 LYS G N   1 
ATOM   4446 C CA  . LYS C 3 169 ? -54.146 4.247   43.759  1.00 83.15  ? 169 LYS G CA  1 
ATOM   4447 C C   . LYS C 3 169 ? -54.376 3.263   44.900  1.00 88.37  ? 169 LYS G C   1 
ATOM   4448 O O   . LYS C 3 169 ? -54.296 3.649   46.070  1.00 97.30  ? 169 LYS G O   1 
ATOM   4449 C CB  . LYS C 3 169 ? -55.452 4.465   42.972  1.00 72.00  ? 169 LYS G CB  1 
ATOM   4450 C CG  . LYS C 3 169 ? -55.447 5.659   42.015  1.00 67.89  ? 169 LYS G CG  1 
ATOM   4451 C CD  . LYS C 3 169 ? -54.820 5.309   40.670  1.00 80.54  ? 169 LYS G CD  1 
ATOM   4452 C CE  . LYS C 3 169 ? -54.865 6.482   39.703  1.00 77.92  ? 169 LYS G CE  1 
ATOM   4453 N NZ  . LYS C 3 169 ? -54.081 7.643   40.203  1.00 64.35  ? 169 LYS G NZ  1 
ATOM   4454 N N   . ASP C 3 170 ? -54.659 1.994   44.597  1.00 89.67  ? 170 ASP G N   1 
ATOM   4455 C CA  . ASP C 3 170 ? -54.861 0.979   45.625  1.00 87.10  ? 170 ASP G CA  1 
ATOM   4456 C C   . ASP C 3 170 ? -53.726 -0.036  45.697  1.00 78.92  ? 170 ASP G C   1 
ATOM   4457 O O   . ASP C 3 170 ? -53.789 -0.952  46.526  1.00 79.79  ? 170 ASP G O   1 
ATOM   4458 C CB  . ASP C 3 170 ? -56.197 0.252   45.409  1.00 75.96  ? 170 ASP G CB  1 
ATOM   4459 C CG  . ASP C 3 170 ? -56.338 -0.314  44.011  1.00 89.54  ? 170 ASP G CG  1 
ATOM   4460 O OD1 . ASP C 3 170 ? -55.424 -0.101  43.188  1.00 96.68  ? 170 ASP G OD1 1 
ATOM   4461 O OD2 . ASP C 3 170 ? -57.364 -0.972  43.734  1.00 93.76  ? 170 ASP G OD2 1 
ATOM   4462 N N   . SER C 3 171 ? -52.696 0.106   44.857  1.00 81.89  ? 171 SER G N   1 
ATOM   4463 C CA  . SER C 3 171 ? -51.495 -0.733  44.908  1.00 76.32  ? 171 SER G CA  1 
ATOM   4464 C C   . SER C 3 171 ? -51.820 -2.218  44.762  1.00 80.79  ? 171 SER G C   1 
ATOM   4465 O O   . SER C 3 171 ? -51.276 -3.065  45.474  1.00 77.45  ? 171 SER G O   1 
ATOM   4466 C CB  . SER C 3 171 ? -50.705 -0.477  46.190  1.00 61.83  ? 171 SER G CB  1 
ATOM   4467 O OG  . SER C 3 171 ? -50.075 0.791   46.153  1.00 79.97  ? 171 SER G OG  1 
ATOM   4468 N N   . THR C 3 172 ? -52.705 -2.539  43.826  1.00 74.85  ? 172 THR G N   1 
ATOM   4469 C CA  . THR C 3 172 ? -53.103 -3.911  43.557  1.00 62.69  ? 172 THR G CA  1 
ATOM   4470 C C   . THR C 3 172 ? -52.537 -4.365  42.216  1.00 67.11  ? 172 THR G C   1 
ATOM   4471 O O   . THR C 3 172 ? -51.891 -3.605  41.488  1.00 70.79  ? 172 THR G O   1 
ATOM   4472 C CB  . THR C 3 172 ? -54.626 -4.052  43.570  1.00 65.34  ? 172 THR G CB  1 
ATOM   4473 O OG1 . THR C 3 172 ? -55.193 -3.214  42.555  1.00 69.75  ? 172 THR G OG1 1 
ATOM   4474 C CG2 . THR C 3 172 ? -55.187 -3.662  44.925  1.00 68.21  ? 172 THR G CG2 1 
ATOM   4475 N N   . TYR C 3 173 ? -52.796 -5.627  41.895  1.00 66.20  ? 173 TYR G N   1 
ATOM   4476 C CA  . TYR C 3 173 ? -52.370 -6.231  40.647  1.00 50.78  ? 173 TYR G CA  1 
ATOM   4477 C C   . TYR C 3 173 ? -53.585 -6.659  39.834  1.00 57.77  ? 173 TYR G C   1 
ATOM   4478 O O   . TYR C 3 173 ? -54.692 -6.820  40.359  1.00 51.46  ? 173 TYR G O   1 
ATOM   4479 C CB  . TYR C 3 173 ? -51.468 -7.446  40.893  1.00 54.89  ? 173 TYR G CB  1 
ATOM   4480 C CG  . TYR C 3 173 ? -50.043 -7.122  41.285  1.00 59.40  ? 173 TYR G CG  1 
ATOM   4481 C CD1 . TYR C 3 173 ? -49.703 -6.866  42.608  1.00 54.08  ? 173 TYR G CD1 1 
ATOM   4482 C CD2 . TYR C 3 173 ? -49.032 -7.101  40.333  1.00 57.64  ? 173 TYR G CD2 1 
ATOM   4483 C CE1 . TYR C 3 173 ? -48.395 -6.585  42.967  1.00 61.15  ? 173 TYR G CE1 1 
ATOM   4484 C CE2 . TYR C 3 173 ? -47.726 -6.821  40.682  1.00 61.24  ? 173 TYR G CE2 1 
ATOM   4485 C CZ  . TYR C 3 173 ? -47.412 -6.566  41.998  1.00 65.37  ? 173 TYR G CZ  1 
ATOM   4486 O OH  . TYR C 3 173 ? -46.109 -6.287  42.343  1.00 68.50  ? 173 TYR G OH  1 
ATOM   4487 N N   . SER C 3 174 ? -53.362 -6.834  38.536  1.00 51.59  ? 174 SER G N   1 
ATOM   4488 C CA  . SER C 3 174 ? -54.368 -7.382  37.643  1.00 43.60  ? 174 SER G CA  1 
ATOM   4489 C C   . SER C 3 174 ? -53.712 -8.406  36.732  1.00 51.34  ? 174 SER G C   1 
ATOM   4490 O O   . SER C 3 174 ? -52.608 -8.183  36.226  1.00 46.37  ? 174 SER G O   1 
ATOM   4491 C CB  . SER C 3 174 ? -55.045 -6.282  36.825  1.00 44.15  ? 174 SER G CB  1 
ATOM   4492 O OG  . SER C 3 174 ? -55.797 -5.438  37.678  1.00 55.79  ? 174 SER G OG  1 
ATOM   4493 N N   . LEU C 3 175 ? -54.393 -9.532  36.537  1.00 41.06  ? 175 LEU G N   1 
ATOM   4494 C CA  . LEU C 3 175 ? -53.867 -10.633 35.746  1.00 44.14  ? 175 LEU G CA  1 
ATOM   4495 C C   . LEU C 3 175 ? -54.909 -11.069 34.728  1.00 45.37  ? 175 LEU G C   1 
ATOM   4496 O O   . LEU C 3 175 ? -56.108 -11.096 35.025  1.00 41.02  ? 175 LEU G O   1 
ATOM   4497 C CB  . LEU C 3 175 ? -53.461 -11.814 36.642  1.00 44.75  ? 175 LEU G CB  1 
ATOM   4498 C CG  . LEU C 3 175 ? -52.874 -13.052 35.962  1.00 44.29  ? 175 LEU G CG  1 
ATOM   4499 C CD1 . LEU C 3 175 ? -51.654 -13.554 36.715  1.00 46.11  ? 175 LEU G CD1 1 
ATOM   4500 C CD2 . LEU C 3 175 ? -53.921 -14.147 35.864  1.00 42.15  ? 175 LEU G CD2 1 
ATOM   4501 N N   . SER C 3 176 ? -54.445 -11.399 33.524  1.00 43.00  ? 176 SER G N   1 
ATOM   4502 C CA  . SER C 3 176 ? -55.309 -11.878 32.453  1.00 46.55  ? 176 SER G CA  1 
ATOM   4503 C C   . SER C 3 176 ? -54.765 -13.202 31.942  1.00 48.64  ? 176 SER G C   1 
ATOM   4504 O O   . SER C 3 176 ? -53.596 -13.286 31.548  1.00 41.51  ? 176 SER G O   1 
ATOM   4505 C CB  . SER C 3 176 ? -55.405 -10.859 31.310  1.00 44.83  ? 176 SER G CB  1 
ATOM   4506 O OG  . SER C 3 176 ? -54.158 -10.688 30.655  1.00 49.86  ? 176 SER G OG  1 
ATOM   4507 N N   . SER C 3 177 ? -55.607 -14.228 31.948  1.00 46.11  ? 177 SER G N   1 
ATOM   4508 C CA  . SER C 3 177 ? -55.267 -15.532 31.399  1.00 40.01  ? 177 SER G CA  1 
ATOM   4509 C C   . SER C 3 177 ? -56.100 -15.747 30.143  1.00 39.74  ? 177 SER G C   1 
ATOM   4510 O O   . SER C 3 177 ? -57.334 -15.713 30.200  1.00 43.13  ? 177 SER G O   1 
ATOM   4511 C CB  . SER C 3 177 ? -55.519 -16.639 32.422  1.00 41.66  ? 177 SER G CB  1 
ATOM   4512 O OG  . SER C 3 177 ? -55.005 -17.877 31.967  1.00 46.44  ? 177 SER G OG  1 
ATOM   4513 N N   . THR C 3 178 ? -55.428 -15.954 29.014  1.00 44.44  ? 178 THR G N   1 
ATOM   4514 C CA  . THR C 3 178 ? -56.084 -16.075 27.717  1.00 43.92  ? 178 THR G CA  1 
ATOM   4515 C C   . THR C 3 178 ? -55.884 -17.487 27.183  1.00 50.08  ? 178 THR G C   1 
ATOM   4516 O O   . THR C 3 178 ? -54.745 -17.951 27.054  1.00 49.94  ? 178 THR G O   1 
ATOM   4517 C CB  . THR C 3 178 ? -55.539 -15.048 26.724  1.00 45.53  ? 178 THR G CB  1 
ATOM   4518 O OG1 . THR C 3 178 ? -55.752 -13.723 27.229  1.00 61.86  ? 178 THR G OG1 1 
ATOM   4519 C CG2 . THR C 3 178 ? -56.233 -15.192 25.378  1.00 47.19  ? 178 THR G CG2 1 
ATOM   4520 N N   . LEU C 3 179 ? -56.990 -18.159 26.867  1.00 50.34  ? 179 LEU G N   1 
ATOM   4521 C CA  . LEU C 3 179 ? -56.970 -19.495 26.284  1.00 44.39  ? 179 LEU G CA  1 
ATOM   4522 C C   . LEU C 3 179 ? -57.272 -19.381 24.794  1.00 43.06  ? 179 LEU G C   1 
ATOM   4523 O O   . LEU C 3 179 ? -58.374 -18.975 24.410  1.00 55.36  ? 179 LEU G O   1 
ATOM   4524 C CB  . LEU C 3 179 ? -57.990 -20.407 26.967  1.00 50.52  ? 179 LEU G CB  1 
ATOM   4525 C CG  . LEU C 3 179 ? -57.981 -21.894 26.589  1.00 51.66  ? 179 LEU G CG  1 
ATOM   4526 C CD1 . LEU C 3 179 ? -56.965 -22.657 27.421  1.00 45.55  ? 179 LEU G CD1 1 
ATOM   4527 C CD2 . LEU C 3 179 ? -59.363 -22.506 26.739  1.00 49.61  ? 179 LEU G CD2 1 
ATOM   4528 N N   . THR C 3 180 ? -56.297 -19.728 23.962  1.00 45.88  ? 180 THR G N   1 
ATOM   4529 C CA  . THR C 3 180 ? -56.430 -19.635 22.515  1.00 49.50  ? 180 THR G CA  1 
ATOM   4530 C C   . THR C 3 180 ? -56.637 -21.025 21.931  1.00 56.58  ? 180 THR G C   1 
ATOM   4531 O O   . THR C 3 180 ? -55.832 -21.931 22.172  1.00 54.65  ? 180 THR G O   1 
ATOM   4532 C CB  . THR C 3 180 ? -55.198 -18.968 21.896  1.00 70.95  ? 180 THR G CB  1 
ATOM   4533 O OG1 . THR C 3 180 ? -55.237 -17.558 22.154  1.00 73.64  ? 180 THR G OG1 1 
ATOM   4534 C CG2 . THR C 3 180 ? -55.148 -19.207 20.395  1.00 56.91  ? 180 THR G CG2 1 
ATOM   4535 N N   . LEU C 3 181 ? -57.717 -21.187 21.167  1.00 60.88  ? 181 LEU G N   1 
ATOM   4536 C CA  . LEU C 3 181 ? -58.039 -22.443 20.505  1.00 48.90  ? 181 LEU G CA  1 
ATOM   4537 C C   . LEU C 3 181 ? -58.540 -22.160 19.099  1.00 53.26  ? 181 LEU G C   1 
ATOM   4538 O O   . LEU C 3 181 ? -59.084 -21.087 18.824  1.00 57.16  ? 181 LEU G O   1 
ATOM   4539 C CB  . LEU C 3 181 ? -59.107 -23.231 21.266  1.00 38.22  ? 181 LEU G CB  1 
ATOM   4540 C CG  . LEU C 3 181 ? -58.612 -24.108 22.408  1.00 61.92  ? 181 LEU G CG  1 
ATOM   4541 C CD1 . LEU C 3 181 ? -59.808 -24.630 23.182  1.00 51.06  ? 181 LEU G CD1 1 
ATOM   4542 C CD2 . LEU C 3 181 ? -57.749 -25.251 21.870  1.00 55.97  ? 181 LEU G CD2 1 
ATOM   4543 N N   . SER C 3 182 ? -58.353 -23.130 18.209  1.00 60.54  ? 182 SER G N   1 
ATOM   4544 C CA  . SER C 3 182 ? -58.998 -23.059 16.908  1.00 58.35  ? 182 SER G CA  1 
ATOM   4545 C C   . SER C 3 182 ? -60.505 -23.194 17.078  1.00 53.81  ? 182 SER G C   1 
ATOM   4546 O O   . SER C 3 182 ? -60.990 -23.868 17.991  1.00 63.42  ? 182 SER G O   1 
ATOM   4547 C CB  . SER C 3 182 ? -58.476 -24.153 15.978  1.00 50.64  ? 182 SER G CB  1 
ATOM   4548 O OG  . SER C 3 182 ? -58.840 -25.439 16.447  1.00 65.45  ? 182 SER G OG  1 
ATOM   4549 N N   . LYS C 3 183 ? -61.253 -22.534 16.192  1.00 50.97  ? 183 LYS G N   1 
ATOM   4550 C CA  . LYS C 3 183 ? -62.707 -22.570 16.308  1.00 50.55  ? 183 LYS G CA  1 
ATOM   4551 C C   . LYS C 3 183 ? -63.247 -23.985 16.138  1.00 57.69  ? 183 LYS G C   1 
ATOM   4552 O O   . LYS C 3 183 ? -64.282 -24.326 16.721  1.00 54.15  ? 183 LYS G O   1 
ATOM   4553 C CB  . LYS C 3 183 ? -63.346 -21.629 15.290  1.00 46.01  ? 183 LYS G CB  1 
ATOM   4554 C CG  . LYS C 3 183 ? -64.862 -21.573 15.382  1.00 61.37  ? 183 LYS G CG  1 
ATOM   4555 C CD  . LYS C 3 183 ? -65.439 -20.686 14.302  1.00 71.13  ? 183 LYS G CD  1 
ATOM   4556 C CE  . LYS C 3 183 ? -66.705 -21.279 13.714  1.00 57.94  ? 183 LYS G CE  1 
ATOM   4557 N NZ  . LYS C 3 183 ? -66.621 -21.326 12.229  1.00 62.92  ? 183 LYS G NZ  1 
ATOM   4558 N N   . ALA C 3 184 ? -62.561 -24.821 15.354  1.00 64.34  ? 184 ALA G N   1 
ATOM   4559 C CA  . ALA C 3 184 ? -62.959 -26.222 15.247  1.00 50.05  ? 184 ALA G CA  1 
ATOM   4560 C C   . ALA C 3 184 ? -62.830 -26.934 16.589  1.00 60.97  ? 184 ALA G C   1 
ATOM   4561 O O   . ALA C 3 184 ? -63.733 -27.672 16.998  1.00 70.83  ? 184 ALA G O   1 
ATOM   4562 C CB  . ALA C 3 184 ? -62.123 -26.926 14.178  1.00 49.76  ? 184 ALA G CB  1 
ATOM   4563 N N   . ASP C 3 185 ? -61.715 -26.722 17.292  1.00 54.29  ? 185 ASP G N   1 
ATOM   4564 C CA  . ASP C 3 185 ? -61.581 -27.272 18.636  1.00 61.21  ? 185 ASP G CA  1 
ATOM   4565 C C   . ASP C 3 185 ? -62.522 -26.588 19.616  1.00 60.02  ? 185 ASP G C   1 
ATOM   4566 O O   . ASP C 3 185 ? -62.938 -27.202 20.605  1.00 64.61  ? 185 ASP G O   1 
ATOM   4567 C CB  . ASP C 3 185 ? -60.136 -27.148 19.117  1.00 67.66  ? 185 ASP G CB  1 
ATOM   4568 C CG  . ASP C 3 185 ? -59.205 -28.105 18.407  1.00 94.27  ? 185 ASP G CG  1 
ATOM   4569 O OD1 . ASP C 3 185 ? -59.074 -28.002 17.169  1.00 88.97  ? 185 ASP G OD1 1 
ATOM   4570 O OD2 . ASP C 3 185 ? -58.603 -28.961 19.088  1.00 102.61 ? 185 ASP G OD2 1 
ATOM   4571 N N   . TYR C 3 186 ? -62.860 -25.320 19.367  1.00 51.22  ? 186 TYR G N   1 
ATOM   4572 C CA  . TYR C 3 186 ? -63.746 -24.596 20.273  1.00 46.36  ? 186 TYR G CA  1 
ATOM   4573 C C   . TYR C 3 186 ? -65.151 -25.181 20.260  1.00 58.88  ? 186 TYR G C   1 
ATOM   4574 O O   . TYR C 3 186 ? -65.802 -25.274 21.308  1.00 63.68  ? 186 TYR G O   1 
ATOM   4575 C CB  . TYR C 3 186 ? -63.778 -23.113 19.904  1.00 43.06  ? 186 TYR G CB  1 
ATOM   4576 C CG  . TYR C 3 186 ? -64.706 -22.294 20.773  1.00 44.05  ? 186 TYR G CG  1 
ATOM   4577 C CD1 . TYR C 3 186 ? -64.358 -21.968 22.077  1.00 41.36  ? 186 TYR G CD1 1 
ATOM   4578 C CD2 . TYR C 3 186 ? -65.929 -21.847 20.290  1.00 58.70  ? 186 TYR G CD2 1 
ATOM   4579 C CE1 . TYR C 3 186 ? -65.202 -21.221 22.877  1.00 44.86  ? 186 TYR G CE1 1 
ATOM   4580 C CE2 . TYR C 3 186 ? -66.780 -21.098 21.084  1.00 50.48  ? 186 TYR G CE2 1 
ATOM   4581 C CZ  . TYR C 3 186 ? -66.411 -20.790 22.377  1.00 46.54  ? 186 TYR G CZ  1 
ATOM   4582 O OH  . TYR C 3 186 ? -67.250 -20.046 23.175  1.00 52.80  ? 186 TYR G OH  1 
ATOM   4583 N N   . GLU C 3 187 ? -65.638 -25.578 19.082  1.00 67.47  ? 187 GLU G N   1 
ATOM   4584 C CA  . GLU C 3 187 ? -66.967 -26.165 18.970  1.00 67.84  ? 187 GLU G CA  1 
ATOM   4585 C C   . GLU C 3 187 ? -67.025 -27.597 19.488  1.00 62.53  ? 187 GLU G C   1 
ATOM   4586 O O   . GLU C 3 187 ? -68.127 -28.130 19.661  1.00 59.79  ? 187 GLU G O   1 
ATOM   4587 C CB  . GLU C 3 187 ? -67.437 -26.117 17.512  1.00 76.02  ? 187 GLU G CB  1 
ATOM   4588 C CG  . GLU C 3 187 ? -67.398 -24.727 16.873  1.00 69.87  ? 187 GLU G CG  1 
ATOM   4589 C CD  . GLU C 3 187 ? -68.359 -23.742 17.518  1.00 76.21  ? 187 GLU G CD  1 
ATOM   4590 O OE1 . GLU C 3 187 ? -69.330 -24.184 18.168  1.00 82.84  ? 187 GLU G OE1 1 
ATOM   4591 O OE2 . GLU C 3 187 ? -68.142 -22.520 17.370  1.00 78.21  ? 187 GLU G OE2 1 
ATOM   4592 N N   . LYS C 3 188 ? -65.878 -28.220 19.756  1.00 60.37  ? 188 LYS G N   1 
ATOM   4593 C CA  . LYS C 3 188 ? -65.828 -29.588 20.259  1.00 53.73  ? 188 LYS G CA  1 
ATOM   4594 C C   . LYS C 3 188 ? -66.040 -29.678 21.764  1.00 50.16  ? 188 LYS G C   1 
ATOM   4595 O O   . LYS C 3 188 ? -66.032 -30.788 22.306  1.00 58.73  ? 188 LYS G O   1 
ATOM   4596 C CB  . LYS C 3 188 ? -64.488 -30.235 19.896  1.00 54.69  ? 188 LYS G CB  1 
ATOM   4597 C CG  . LYS C 3 188 ? -64.327 -30.563 18.420  1.00 51.44  ? 188 LYS G CG  1 
ATOM   4598 C CD  . LYS C 3 188 ? -62.955 -31.155 18.134  1.00 62.53  ? 188 LYS G CD  1 
ATOM   4599 C CE  . LYS C 3 188 ? -62.856 -31.691 16.710  1.00 74.70  ? 188 LYS G CE  1 
ATOM   4600 N NZ  . LYS C 3 188 ? -63.749 -32.862 16.462  1.00 73.47  ? 188 LYS G NZ  1 
ATOM   4601 N N   . HIS C 3 189 ? -66.222 -28.551 22.447  1.00 48.09  ? 189 HIS G N   1 
ATOM   4602 C CA  . HIS C 3 189 ? -66.385 -28.525 23.891  1.00 51.40  ? 189 HIS G CA  1 
ATOM   4603 C C   . HIS C 3 189 ? -67.535 -27.600 24.261  1.00 46.60  ? 189 HIS G C   1 
ATOM   4604 O O   . HIS C 3 189 ? -67.930 -26.724 23.489  1.00 53.01  ? 189 HIS G O   1 
ATOM   4605 C CB  . HIS C 3 189 ? -65.104 -28.068 24.592  1.00 59.09  ? 189 HIS G CB  1 
ATOM   4606 C CG  . HIS C 3 189 ? -63.897 -28.874 24.230  1.00 63.53  ? 189 HIS G CG  1 
ATOM   4607 N ND1 . HIS C 3 189 ? -62.979 -28.458 23.289  1.00 57.66  ? 189 HIS G ND1 1 
ATOM   4608 C CD2 . HIS C 3 189 ? -63.457 -30.073 24.681  1.00 65.58  ? 189 HIS G CD2 1 
ATOM   4609 C CE1 . HIS C 3 189 ? -62.025 -29.364 23.177  1.00 51.35  ? 189 HIS G CE1 1 
ATOM   4610 N NE2 . HIS C 3 189 ? -62.291 -30.354 24.010  1.00 77.36  ? 189 HIS G NE2 1 
ATOM   4611 N N   . LYS C 3 190 ? -68.069 -27.802 25.464  1.00 40.06  ? 190 LYS G N   1 
ATOM   4612 C CA  . LYS C 3 190 ? -69.242 -27.071 25.922  1.00 49.32  ? 190 LYS G CA  1 
ATOM   4613 C C   . LYS C 3 190 ? -68.936 -26.117 27.066  1.00 42.52  ? 190 LYS G C   1 
ATOM   4614 O O   . LYS C 3 190 ? -69.268 -24.930 26.987  1.00 44.50  ? 190 LYS G O   1 
ATOM   4615 C CB  . LYS C 3 190 ? -70.338 -28.061 26.350  1.00 41.81  ? 190 LYS G CB  1 
ATOM   4616 C CG  . LYS C 3 190 ? -71.734 -27.461 26.412  1.00 44.79  ? 190 LYS G CG  1 
ATOM   4617 C CD  . LYS C 3 190 ? -72.201 -27.029 25.029  1.00 63.30  ? 190 LYS G CD  1 
ATOM   4618 C CE  . LYS C 3 190 ? -73.705 -26.805 24.982  1.00 71.04  ? 190 LYS G CE  1 
ATOM   4619 N NZ  . LYS C 3 190 ? -74.192 -26.687 23.577  1.00 71.81  ? 190 LYS G NZ  1 
ATOM   4620 N N   . VAL C 3 191 ? -68.301 -26.606 28.128  1.00 48.11  ? 191 VAL G N   1 
ATOM   4621 C CA  . VAL C 3 191 ? -68.066 -25.828 29.338  1.00 41.69  ? 191 VAL G CA  1 
ATOM   4622 C C   . VAL C 3 191 ? -66.635 -25.307 29.333  1.00 39.53  ? 191 VAL G C   1 
ATOM   4623 O O   . VAL C 3 191 ? -65.681 -26.082 29.181  1.00 40.18  ? 191 VAL G O   1 
ATOM   4624 C CB  . VAL C 3 191 ? -68.335 -26.668 30.597  1.00 36.53  ? 191 VAL G CB  1 
ATOM   4625 C CG1 . VAL C 3 191 ? -68.071 -25.846 31.845  1.00 29.43  ? 191 VAL G CG1 1 
ATOM   4626 C CG2 . VAL C 3 191 ? -69.761 -27.191 30.583  1.00 38.68  ? 191 VAL G CG2 1 
ATOM   4627 N N   . TYR C 3 192 ? -66.487 -23.996 29.504  1.00 36.65  ? 192 TYR G N   1 
ATOM   4628 C CA  . TYR C 3 192 ? -65.187 -23.345 29.626  1.00 40.56  ? 192 TYR G CA  1 
ATOM   4629 C C   . TYR C 3 192 ? -65.125 -22.675 30.992  1.00 43.16  ? 192 TYR G C   1 
ATOM   4630 O O   . TYR C 3 192 ? -65.809 -21.673 31.228  1.00 47.42  ? 192 TYR G O   1 
ATOM   4631 C CB  . TYR C 3 192 ? -64.970 -22.338 28.497  1.00 30.92  ? 192 TYR G CB  1 
ATOM   4632 C CG  . TYR C 3 192 ? -64.692 -22.994 27.165  1.00 39.97  ? 192 TYR G CG  1 
ATOM   4633 C CD1 . TYR C 3 192 ? -65.729 -23.348 26.311  1.00 38.11  ? 192 TYR G CD1 1 
ATOM   4634 C CD2 . TYR C 3 192 ? -63.391 -23.278 26.768  1.00 44.32  ? 192 TYR G CD2 1 
ATOM   4635 C CE1 . TYR C 3 192 ? -65.477 -23.958 25.095  1.00 47.45  ? 192 TYR G CE1 1 
ATOM   4636 C CE2 . TYR C 3 192 ? -63.129 -23.887 25.556  1.00 45.59  ? 192 TYR G CE2 1 
ATOM   4637 C CZ  . TYR C 3 192 ? -64.176 -24.225 24.723  1.00 52.93  ? 192 TYR G CZ  1 
ATOM   4638 O OH  . TYR C 3 192 ? -63.924 -24.833 23.514  1.00 62.24  ? 192 TYR G OH  1 
ATOM   4639 N N   . ALA C 3 193 ? -64.314 -23.227 31.891  1.00 33.93  ? 193 ALA G N   1 
ATOM   4640 C CA  . ALA C 3 193 ? -64.221 -22.737 33.257  1.00 38.52  ? 193 ALA G CA  1 
ATOM   4641 C C   . ALA C 3 193 ? -62.818 -22.223 33.546  1.00 42.04  ? 193 ALA G C   1 
ATOM   4642 O O   . ALA C 3 193 ? -61.825 -22.723 33.007  1.00 33.81  ? 193 ALA G O   1 
ATOM   4643 C CB  . ALA C 3 193 ? -64.593 -23.825 34.269  1.00 31.47  ? 193 ALA G CB  1 
ATOM   4644 N N   . CYS C 3 194 ? -62.753 -21.211 34.405  1.00 45.64  ? 194 CYS G N   1 
ATOM   4645 C CA  . CYS C 3 194 ? -61.503 -20.596 34.835  1.00 42.45  ? 194 CYS G CA  1 
ATOM   4646 C C   . CYS C 3 194 ? -61.447 -20.672 36.355  1.00 45.40  ? 194 CYS G C   1 
ATOM   4647 O O   . CYS C 3 194 ? -62.246 -20.026 37.042  1.00 49.89  ? 194 CYS G O   1 
ATOM   4648 C CB  . CYS C 3 194 ? -61.414 -19.152 34.345  1.00 41.93  ? 194 CYS G CB  1 
ATOM   4649 S SG  . CYS C 3 194 ? -59.993 -18.248 34.971  1.00 85.78  ? 194 CYS G SG  1 
ATOM   4650 N N   . GLU C 3 195 ? -60.516 -21.466 36.880  1.00 35.70  ? 195 GLU G N   1 
ATOM   4651 C CA  . GLU C 3 195 ? -60.402 -21.700 38.314  1.00 37.81  ? 195 GLU G CA  1 
ATOM   4652 C C   . GLU C 3 195 ? -59.221 -20.917 38.871  1.00 49.34  ? 195 GLU G C   1 
ATOM   4653 O O   . GLU C 3 195 ? -58.094 -21.050 38.383  1.00 46.43  ? 195 GLU G O   1 
ATOM   4654 C CB  . GLU C 3 195 ? -60.238 -23.190 38.613  1.00 37.48  ? 195 GLU G CB  1 
ATOM   4655 C CG  . GLU C 3 195 ? -60.307 -23.536 40.091  1.00 52.43  ? 195 GLU G CG  1 
ATOM   4656 C CD  . GLU C 3 195 ? -60.178 -25.024 40.340  1.00 65.09  ? 195 GLU G CD  1 
ATOM   4657 O OE1 . GLU C 3 195 ? -60.472 -25.810 39.414  1.00 61.50  ? 195 GLU G OE1 1 
ATOM   4658 O OE2 . GLU C 3 195 ? -59.777 -25.409 41.459  1.00 62.82  ? 195 GLU G OE2 1 
ATOM   4659 N N   . VAL C 3 196 ? -59.483 -20.119 39.904  1.00 55.66  ? 196 VAL G N   1 
ATOM   4660 C CA  . VAL C 3 196 ? -58.521 -19.168 40.445  1.00 48.22  ? 196 VAL G CA  1 
ATOM   4661 C C   . VAL C 3 196 ? -58.225 -19.532 41.892  1.00 49.52  ? 196 VAL G C   1 
ATOM   4662 O O   . VAL C 3 196 ? -59.148 -19.683 42.701  1.00 47.25  ? 196 VAL G O   1 
ATOM   4663 C CB  . VAL C 3 196 ? -59.045 -17.724 40.348  1.00 43.65  ? 196 VAL G CB  1 
ATOM   4664 C CG1 . VAL C 3 196 ? -58.128 -16.776 41.102  1.00 44.52  ? 196 VAL G CG1 1 
ATOM   4665 C CG2 . VAL C 3 196 ? -59.178 -17.306 38.894  1.00 44.72  ? 196 VAL G CG2 1 
ATOM   4666 N N   . THR C 3 197 ? -56.942 -19.664 42.214  1.00 46.62  ? 197 THR G N   1 
ATOM   4667 C CA  . THR C 3 197 ? -56.481 -19.902 43.574  1.00 50.37  ? 197 THR G CA  1 
ATOM   4668 C C   . THR C 3 197 ? -55.663 -18.704 44.031  1.00 56.97  ? 197 THR G C   1 
ATOM   4669 O O   . THR C 3 197 ? -54.723 -18.291 43.344  1.00 55.42  ? 197 THR G O   1 
ATOM   4670 C CB  . THR C 3 197 ? -55.644 -21.180 43.663  1.00 49.27  ? 197 THR G CB  1 
ATOM   4671 O OG1 . THR C 3 197 ? -56.460 -22.308 43.323  1.00 51.93  ? 197 THR G OG1 1 
ATOM   4672 C CG2 . THR C 3 197 ? -55.091 -21.363 45.070  1.00 42.40  ? 197 THR G CG2 1 
ATOM   4673 N N   . HIS C 3 198 ? -56.020 -18.150 45.186  1.00 54.93  ? 198 HIS G N   1 
ATOM   4674 C CA  . HIS C 3 198 ? -55.333 -16.979 45.704  1.00 45.28  ? 198 HIS G CA  1 
ATOM   4675 C C   . HIS C 3 198 ? -55.406 -16.994 47.221  1.00 45.61  ? 198 HIS G C   1 
ATOM   4676 O O   . HIS C 3 198 ? -56.273 -17.640 47.814  1.00 59.55  ? 198 HIS G O   1 
ATOM   4677 C CB  . HIS C 3 198 ? -55.939 -15.687 45.148  1.00 46.14  ? 198 HIS G CB  1 
ATOM   4678 C CG  . HIS C 3 198 ? -55.145 -14.461 45.471  1.00 51.38  ? 198 HIS G CG  1 
ATOM   4679 N ND1 . HIS C 3 198 ? -55.528 -13.559 46.440  1.00 49.23  ? 198 HIS G ND1 1 
ATOM   4680 C CD2 . HIS C 3 198 ? -53.983 -13.991 44.958  1.00 53.52  ? 198 HIS G CD2 1 
ATOM   4681 C CE1 . HIS C 3 198 ? -54.639 -12.584 46.507  1.00 51.59  ? 198 HIS G CE1 1 
ATOM   4682 N NE2 . HIS C 3 198 ? -53.691 -12.823 45.618  1.00 51.23  ? 198 HIS G NE2 1 
ATOM   4683 N N   . GLN C 3 199 ? -54.480 -16.265 47.847  1.00 41.47  ? 199 GLN G N   1 
ATOM   4684 C CA  . GLN C 3 199 ? -54.451 -16.205 49.305  1.00 56.72  ? 199 GLN G CA  1 
ATOM   4685 C C   . GLN C 3 199 ? -55.719 -15.578 49.864  1.00 50.38  ? 199 GLN G C   1 
ATOM   4686 O O   . GLN C 3 199 ? -56.233 -16.018 50.900  1.00 61.30  ? 199 GLN G O   1 
ATOM   4687 C CB  . GLN C 3 199 ? -53.224 -15.431 49.778  1.00 56.80  ? 199 GLN G CB  1 
ATOM   4688 C CG  . GLN C 3 199 ? -53.284 -15.051 51.245  1.00 50.90  ? 199 GLN G CG  1 
ATOM   4689 C CD  . GLN C 3 199 ? -51.944 -14.618 51.782  1.00 65.08  ? 199 GLN G CD  1 
ATOM   4690 O OE1 . GLN C 3 199 ? -50.906 -14.921 51.195  1.00 77.48  ? 199 GLN G OE1 1 
ATOM   4691 N NE2 . GLN C 3 199 ? -51.954 -13.904 52.901  1.00 56.26  ? 199 GLN G NE2 1 
ATOM   4692 N N   . GLY C 3 200 ? -56.234 -14.546 49.202  1.00 45.25  ? 200 GLY G N   1 
ATOM   4693 C CA  . GLY C 3 200 ? -57.432 -13.869 49.674  1.00 46.15  ? 200 GLY G CA  1 
ATOM   4694 C C   . GLY C 3 200 ? -58.709 -14.665 49.517  1.00 51.14  ? 200 GLY G C   1 
ATOM   4695 O O   . GLY C 3 200 ? -59.765 -14.203 49.962  1.00 49.32  ? 200 GLY G O   1 
ATOM   4696 N N   . LEU C 3 201 ? -58.641 -15.835 48.892  1.00 48.27  ? 201 LEU G N   1 
ATOM   4697 C CA  . LEU C 3 201 ? -59.787 -16.713 48.714  1.00 47.13  ? 201 LEU G CA  1 
ATOM   4698 C C   . LEU C 3 201 ? -59.631 -17.926 49.618  1.00 42.65  ? 201 LEU G C   1 
ATOM   4699 O O   . LEU C 3 201 ? -58.608 -18.618 49.564  1.00 45.28  ? 201 LEU G O   1 
ATOM   4700 C CB  . LEU C 3 201 ? -59.911 -17.154 47.254  1.00 47.06  ? 201 LEU G CB  1 
ATOM   4701 C CG  . LEU C 3 201 ? -60.044 -16.030 46.227  1.00 45.69  ? 201 LEU G CG  1 
ATOM   4702 C CD1 . LEU C 3 201 ? -59.874 -16.569 44.813  1.00 44.53  ? 201 LEU G CD1 1 
ATOM   4703 C CD2 . LEU C 3 201 ? -61.386 -15.338 46.387  1.00 38.21  ? 201 LEU G CD2 1 
ATOM   4704 N N   . SER C 3 202 ? -60.642 -18.175 50.454  1.00 54.94  ? 202 SER G N   1 
ATOM   4705 C CA  . SER C 3 202 ? -60.615 -19.349 51.321  1.00 64.73  ? 202 SER G CA  1 
ATOM   4706 C C   . SER C 3 202 ? -60.620 -20.633 50.502  1.00 65.47  ? 202 SER G C   1 
ATOM   4707 O O   . SER C 3 202 ? -59.919 -21.596 50.835  1.00 60.36  ? 202 SER G O   1 
ATOM   4708 C CB  . SER C 3 202 ? -61.802 -19.317 52.285  1.00 55.21  ? 202 SER G CB  1 
ATOM   4709 O OG  . SER C 3 202 ? -63.035 -19.277 51.586  1.00 63.50  ? 202 SER G OG  1 
ATOM   4710 N N   . SER C 3 203 ? -61.410 -20.667 49.433  1.00 68.40  ? 203 SER G N   1 
ATOM   4711 C CA  . SER C 3 203 ? -61.488 -21.780 48.502  1.00 59.42  ? 203 SER G CA  1 
ATOM   4712 C C   . SER C 3 203 ? -61.406 -21.255 47.077  1.00 56.73  ? 203 SER G C   1 
ATOM   4713 O O   . SER C 3 203 ? -61.778 -20.107 46.812  1.00 59.75  ? 203 SER G O   1 
ATOM   4714 C CB  . SER C 3 203 ? -62.790 -22.577 48.694  1.00 59.86  ? 203 SER G CB  1 
ATOM   4715 O OG  . SER C 3 203 ? -63.881 -21.731 49.017  1.00 84.37  ? 203 SER G OG  1 
ATOM   4716 N N   . PRO C 3 204 ? -60.915 -22.070 46.142  1.00 52.41  ? 204 PRO G N   1 
ATOM   4717 C CA  . PRO C 3 204 ? -60.761 -21.596 44.761  1.00 60.41  ? 204 PRO G CA  1 
ATOM   4718 C C   . PRO C 3 204 ? -62.087 -21.146 44.162  1.00 57.64  ? 204 PRO G C   1 
ATOM   4719 O O   . PRO C 3 204 ? -63.143 -21.723 44.432  1.00 54.49  ? 204 PRO G O   1 
ATOM   4720 C CB  . PRO C 3 204 ? -60.198 -22.819 44.029  1.00 49.63  ? 204 PRO G CB  1 
ATOM   4721 C CG  . PRO C 3 204 ? -59.511 -23.603 45.092  1.00 47.66  ? 204 PRO G CG  1 
ATOM   4722 C CD  . PRO C 3 204 ? -60.334 -23.410 46.332  1.00 49.61  ? 204 PRO G CD  1 
ATOM   4723 N N   . VAL C 3 205 ? -62.015 -20.096 43.348  1.00 50.24  ? 205 VAL G N   1 
ATOM   4724 C CA  . VAL C 3 205 ? -63.173 -19.517 42.677  1.00 47.94  ? 205 VAL G CA  1 
ATOM   4725 C C   . VAL C 3 205 ? -63.172 -19.987 41.231  1.00 41.95  ? 205 VAL G C   1 
ATOM   4726 O O   . VAL C 3 205 ? -62.142 -19.920 40.549  1.00 49.88  ? 205 VAL G O   1 
ATOM   4727 C CB  . VAL C 3 205 ? -63.149 -17.980 42.756  1.00 49.77  ? 205 VAL G CB  1 
ATOM   4728 C CG1 . VAL C 3 205 ? -64.196 -17.375 41.827  1.00 43.31  ? 205 VAL G CG1 1 
ATOM   4729 C CG2 . VAL C 3 205 ? -63.361 -17.519 44.190  1.00 41.42  ? 205 VAL G CG2 1 
ATOM   4730 N N   . THR C 3 206 ? -64.320 -20.470 40.763  1.00 42.48  ? 206 THR G N   1 
ATOM   4731 C CA  . THR C 3 206 ? -64.476 -20.941 39.395  1.00 41.81  ? 206 THR G CA  1 
ATOM   4732 C C   . THR C 3 206 ? -65.531 -20.104 38.688  1.00 47.89  ? 206 THR G C   1 
ATOM   4733 O O   . THR C 3 206 ? -66.657 -19.973 39.179  1.00 43.71  ? 206 THR G O   1 
ATOM   4734 C CB  . THR C 3 206 ? -64.864 -22.423 39.364  1.00 43.52  ? 206 THR G CB  1 
ATOM   4735 O OG1 . THR C 3 206 ? -63.832 -23.201 39.985  1.00 61.49  ? 206 THR G OG1 1 
ATOM   4736 C CG2 . THR C 3 206 ? -65.057 -22.898 37.931  1.00 36.85  ? 206 THR G CG2 1 
ATOM   4737 N N   . LYS C 3 207 ? -65.161 -19.535 37.543  1.00 43.15  ? 207 LYS G N   1 
ATOM   4738 C CA  . LYS C 3 207 ? -66.082 -18.817 36.673  1.00 36.60  ? 207 LYS G CA  1 
ATOM   4739 C C   . LYS C 3 207 ? -66.154 -19.557 35.346  1.00 41.25  ? 207 LYS G C   1 
ATOM   4740 O O   . LYS C 3 207 ? -65.118 -19.838 34.734  1.00 49.31  ? 207 LYS G O   1 
ATOM   4741 C CB  . LYS C 3 207 ? -65.628 -17.368 36.462  1.00 39.20  ? 207 LYS G CB  1 
ATOM   4742 C CG  . LYS C 3 207 ? -65.634 -16.519 37.725  1.00 37.68  ? 207 LYS G CG  1 
ATOM   4743 C CD  . LYS C 3 207 ? -67.017 -15.958 38.016  1.00 50.48  ? 207 LYS G CD  1 
ATOM   4744 C CE  . LYS C 3 207 ? -67.012 -15.073 39.256  1.00 50.77  ? 207 LYS G CE  1 
ATOM   4745 N NZ  . LYS C 3 207 ? -68.269 -14.281 39.391  1.00 59.77  ? 207 LYS G NZ  1 
ATOM   4746 N N   . SER C 3 208 ? -67.369 -19.878 34.905  1.00 45.49  ? 208 SER G N   1 
ATOM   4747 C CA  . SER C 3 208 ? -67.555 -20.693 33.714  1.00 52.16  ? 208 SER G CA  1 
ATOM   4748 C C   . SER C 3 208 ? -68.728 -20.170 32.898  1.00 52.01  ? 208 SER G C   1 
ATOM   4749 O O   . SER C 3 208 ? -69.603 -19.463 33.405  1.00 54.46  ? 208 SER G O   1 
ATOM   4750 C CB  . SER C 3 208 ? -67.790 -22.168 34.067  1.00 55.16  ? 208 SER G CB  1 
ATOM   4751 O OG  . SER C 3 208 ? -69.000 -22.335 34.788  1.00 50.81  ? 208 SER G OG  1 
ATOM   4752 N N   . PHE C 3 209 ? -68.732 -20.534 31.618  1.00 44.48  ? 209 PHE G N   1 
ATOM   4753 C CA  . PHE C 3 209 ? -69.829 -20.212 30.719  1.00 49.18  ? 209 PHE G CA  1 
ATOM   4754 C C   . PHE C 3 209 ? -70.072 -21.397 29.796  1.00 53.35  ? 209 PHE G C   1 
ATOM   4755 O O   . PHE C 3 209 ? -69.199 -22.246 29.600  1.00 49.53  ? 209 PHE G O   1 
ATOM   4756 C CB  . PHE C 3 209 ? -69.546 -18.940 29.903  1.00 44.70  ? 209 PHE G CB  1 
ATOM   4757 C CG  . PHE C 3 209 ? -68.410 -19.078 28.924  1.00 40.52  ? 209 PHE G CG  1 
ATOM   4758 C CD1 . PHE C 3 209 ? -67.108 -18.800 29.308  1.00 47.43  ? 209 PHE G CD1 1 
ATOM   4759 C CD2 . PHE C 3 209 ? -68.646 -19.472 27.616  1.00 41.27  ? 209 PHE G CD2 1 
ATOM   4760 C CE1 . PHE C 3 209 ? -66.064 -18.922 28.409  1.00 44.42  ? 209 PHE G CE1 1 
ATOM   4761 C CE2 . PHE C 3 209 ? -67.606 -19.599 26.714  1.00 50.47  ? 209 PHE G CE2 1 
ATOM   4762 C CZ  . PHE C 3 209 ? -66.314 -19.321 27.109  1.00 45.89  ? 209 PHE G CZ  1 
ATOM   4763 N N   . ASN C 3 210 ? -71.276 -21.450 29.231  1.00 54.17  ? 210 ASN G N   1 
ATOM   4764 C CA  . ASN C 3 210 ? -71.657 -22.488 28.283  1.00 48.83  ? 210 ASN G CA  1 
ATOM   4765 C C   . ASN C 3 210 ? -71.690 -21.906 26.878  1.00 52.49  ? 210 ASN G C   1 
ATOM   4766 O O   . ASN C 3 210 ? -72.240 -20.821 26.663  1.00 61.97  ? 210 ASN G O   1 
ATOM   4767 C CB  . ASN C 3 210 ? -73.017 -23.092 28.637  1.00 56.62  ? 210 ASN G CB  1 
ATOM   4768 C CG  . ASN C 3 210 ? -72.907 -24.232 29.625  1.00 59.32  ? 210 ASN G CG  1 
ATOM   4769 O OD1 . ASN C 3 210 ? -71.893 -24.929 29.672  1.00 64.71  ? 210 ASN G OD1 1 
ATOM   4770 N ND2 . ASN C 3 210 ? -73.952 -24.432 30.420  1.00 54.83  ? 210 ASN G ND2 1 
ATOM   4771 N N   . ARG C 3 211 ? -71.100 -22.630 25.928  1.00 47.79  ? 211 ARG G N   1 
ATOM   4772 C CA  . ARG C 3 211 ? -71.059 -22.182 24.543  1.00 53.45  ? 211 ARG G CA  1 
ATOM   4773 C C   . ARG C 3 211 ? -72.465 -22.096 23.962  1.00 66.01  ? 211 ARG G C   1 
ATOM   4774 O O   . ARG C 3 211 ? -73.124 -23.121 23.760  1.00 76.46  ? 211 ARG G O   1 
ATOM   4775 C CB  . ARG C 3 211 ? -70.184 -23.122 23.714  1.00 46.21  ? 211 ARG G CB  1 
ATOM   4776 C CG  . ARG C 3 211 ? -70.146 -22.792 22.237  1.00 65.96  ? 211 ARG G CG  1 
ATOM   4777 C CD  . ARG C 3 211 ? -69.153 -23.682 21.512  1.00 56.89  ? 211 ARG G CD  1 
ATOM   4778 N NE  . ARG C 3 211 ? -69.376 -25.094 21.799  1.00 68.35  ? 211 ARG G NE  1 
ATOM   4779 C CZ  . ARG C 3 211 ? -70.136 -25.899 21.068  1.00 70.72  ? 211 ARG G CZ  1 
ATOM   4780 N NH1 . ARG C 3 211 ? -70.769 -25.462 19.992  1.00 71.70  ? 211 ARG G NH1 1 
ATOM   4781 N NH2 . ARG C 3 211 ? -70.263 -27.174 21.425  1.00 64.80  ? 211 ARG G NH2 1 
ATOM   4782 N N   . GLY C 3 212 ? -72.931 -20.880 23.694  1.00 71.17  ? 212 GLY G N   1 
ATOM   4783 C CA  . GLY C 3 212 ? -74.273 -20.667 23.181  1.00 60.24  ? 212 GLY G CA  1 
ATOM   4784 C C   . GLY C 3 212 ? -75.140 -19.823 24.096  1.00 47.53  ? 212 GLY G C   1 
ATOM   4785 O O   . GLY C 3 212 ? -75.314 -20.143 25.273  1.00 49.47  ? 212 GLY G O   1 
ATOM   4786 N N   . GLN D 4 1   ? 23.929  -6.339  27.678  1.00 68.08  ? 1   GLN H N   1 
ATOM   4787 C CA  . GLN D 4 1   ? 23.772  -7.239  26.542  1.00 72.84  ? 1   GLN H CA  1 
ATOM   4788 C C   . GLN D 4 1   ? 22.591  -8.175  26.768  1.00 69.13  ? 1   GLN H C   1 
ATOM   4789 O O   . GLN D 4 1   ? 22.323  -8.587  27.897  1.00 72.95  ? 1   GLN H O   1 
ATOM   4790 C CB  . GLN D 4 1   ? 25.052  -8.043  26.308  1.00 84.58  ? 1   GLN H CB  1 
ATOM   4791 C CG  . GLN D 4 1   ? 26.323  -7.202  26.261  1.00 89.98  ? 1   GLN H CG  1 
ATOM   4792 C CD  . GLN D 4 1   ? 26.380  -6.274  25.060  1.00 102.09 ? 1   GLN H CD  1 
ATOM   4793 O OE1 . GLN D 4 1   ? 25.654  -6.455  24.081  1.00 107.21 ? 1   GLN H OE1 1 
ATOM   4794 N NE2 . GLN D 4 1   ? 27.252  -5.274  25.129  1.00 84.40  ? 1   GLN H NE2 1 
ATOM   4795 N N   . MET D 4 2   ? 21.886  -8.510  25.690  1.00 67.90  ? 2   MET H N   1 
ATOM   4796 C CA  . MET D 4 2   ? 20.673  -9.312  25.761  1.00 60.44  ? 2   MET H CA  1 
ATOM   4797 C C   . MET D 4 2   ? 20.792  -10.507 24.826  1.00 52.86  ? 2   MET H C   1 
ATOM   4798 O O   . MET D 4 2   ? 21.339  -10.394 23.726  1.00 54.52  ? 2   MET H O   1 
ATOM   4799 C CB  . MET D 4 2   ? 19.442  -8.470  25.403  1.00 63.52  ? 2   MET H CB  1 
ATOM   4800 C CG  . MET D 4 2   ? 18.107  -9.155  25.636  1.00 57.24  ? 2   MET H CG  1 
ATOM   4801 S SD  . MET D 4 2   ? 17.314  -9.591  24.080  1.00 87.23  ? 2   MET H SD  1 
ATOM   4802 C CE  . MET D 4 2   ? 15.639  -9.925  24.617  1.00 63.61  ? 2   MET H CE  1 
ATOM   4803 N N   . GLN D 4 3   ? 20.278  -11.651 25.272  1.00 58.74  ? 3   GLN H N   1 
ATOM   4804 C CA  . GLN D 4 3   ? 20.381  -12.902 24.535  1.00 54.48  ? 3   GLN H CA  1 
ATOM   4805 C C   . GLN D 4 3   ? 18.997  -13.507 24.352  1.00 56.19  ? 3   GLN H C   1 
ATOM   4806 O O   . GLN D 4 3   ? 18.178  -13.494 25.276  1.00 59.30  ? 3   GLN H O   1 
ATOM   4807 C CB  . GLN D 4 3   ? 21.304  -13.894 25.264  1.00 54.01  ? 3   GLN H CB  1 
ATOM   4808 C CG  . GLN D 4 3   ? 21.417  -15.272 24.618  1.00 74.59  ? 3   GLN H CG  1 
ATOM   4809 C CD  . GLN D 4 3   ? 22.334  -15.301 23.401  1.00 95.48  ? 3   GLN H CD  1 
ATOM   4810 O OE1 . GLN D 4 3   ? 22.401  -14.344 22.628  1.00 97.77  ? 3   GLN H OE1 1 
ATOM   4811 N NE2 . GLN D 4 3   ? 23.047  -16.409 23.230  1.00 76.01  ? 3   GLN H NE2 1 
ATOM   4812 N N   . LEU D 4 4   ? 18.740  -14.035 23.156  1.00 59.35  ? 4   LEU H N   1 
ATOM   4813 C CA  . LEU D 4 4   ? 17.480  -14.691 22.827  1.00 48.50  ? 4   LEU H CA  1 
ATOM   4814 C C   . LEU D 4 4   ? 17.725  -16.169 22.559  1.00 48.67  ? 4   LEU H C   1 
ATOM   4815 O O   . LEU D 4 4   ? 18.577  -16.522 21.736  1.00 55.57  ? 4   LEU H O   1 
ATOM   4816 C CB  . LEU D 4 4   ? 16.822  -14.043 21.606  1.00 49.39  ? 4   LEU H CB  1 
ATOM   4817 C CG  . LEU D 4 4   ? 16.077  -12.728 21.835  1.00 46.50  ? 4   LEU H CG  1 
ATOM   4818 C CD1 . LEU D 4 4   ? 15.707  -12.089 20.508  1.00 42.00  ? 4   LEU H CD1 1 
ATOM   4819 C CD2 . LEU D 4 4   ? 14.836  -12.960 22.681  1.00 38.49  ? 4   LEU H CD2 1 
ATOM   4820 N N   . VAL D 4 5   ? 16.971  -17.026 23.245  1.00 41.89  ? 5   VAL H N   1 
ATOM   4821 C CA  . VAL D 4 5   ? 17.055  -18.474 23.081  1.00 50.58  ? 5   VAL H CA  1 
ATOM   4822 C C   . VAL D 4 5   ? 15.675  -18.994 22.702  1.00 49.01  ? 5   VAL H C   1 
ATOM   4823 O O   . VAL D 4 5   ? 14.682  -18.664 23.360  1.00 55.94  ? 5   VAL H O   1 
ATOM   4824 C CB  . VAL D 4 5   ? 17.563  -19.164 24.360  1.00 38.15  ? 5   VAL H CB  1 
ATOM   4825 C CG1 . VAL D 4 5   ? 17.772  -20.646 24.108  1.00 36.53  ? 5   VAL H CG1 1 
ATOM   4826 C CG2 . VAL D 4 5   ? 18.848  -18.514 24.843  1.00 39.89  ? 5   VAL H CG2 1 
ATOM   4827 N N   . GLN D 4 6   ? 15.614  -19.809 21.653  1.00 41.09  ? 6   GLN H N   1 
ATOM   4828 C CA  . GLN D 4 6   ? 14.354  -20.326 21.140  1.00 49.78  ? 6   GLN H CA  1 
ATOM   4829 C C   . GLN D 4 6   ? 14.174  -21.791 21.523  1.00 49.84  ? 6   GLN H C   1 
ATOM   4830 O O   . GLN D 4 6   ? 15.075  -22.441 22.061  1.00 51.37  ? 6   GLN H O   1 
ATOM   4831 C CB  . GLN D 4 6   ? 14.279  -20.164 19.618  1.00 47.72  ? 6   GLN H CB  1 
ATOM   4832 C CG  . GLN D 4 6   ? 14.664  -18.787 19.119  1.00 39.92  ? 6   GLN H CG  1 
ATOM   4833 C CD  . GLN D 4 6   ? 14.264  -18.560 17.677  1.00 46.19  ? 6   GLN H CD  1 
ATOM   4834 O OE1 . GLN D 4 6   ? 14.950  -17.858 16.931  1.00 44.88  ? 6   GLN H OE1 1 
ATOM   4835 N NE2 . GLN D 4 6   ? 13.144  -19.151 17.275  1.00 43.76  ? 6   GLN H NE2 1 
ATOM   4836 N N   . SER D 4 7   ? 12.984  -22.309 21.225  1.00 50.47  ? 7   SER H N   1 
ATOM   4837 C CA  . SER D 4 7   ? 12.649  -23.693 21.515  1.00 44.99  ? 7   SER H CA  1 
ATOM   4838 C C   . SER D 4 7   ? 13.286  -24.620 20.478  1.00 54.07  ? 7   SER H C   1 
ATOM   4839 O O   . SER D 4 7   ? 13.954  -24.183 19.536  1.00 44.96  ? 7   SER H O   1 
ATOM   4840 C CB  . SER D 4 7   ? 11.132  -23.872 21.570  1.00 44.03  ? 7   SER H CB  1 
ATOM   4841 O OG  . SER D 4 7   ? 10.527  -23.557 20.329  1.00 53.14  ? 7   SER H OG  1 
ATOM   4842 N N   . GLY D 4 8   ? 13.075  -25.924 20.655  1.00 52.68  ? 8   GLY H N   1 
ATOM   4843 C CA  . GLY D 4 8   ? 13.726  -26.918 19.830  1.00 45.76  ? 8   GLY H CA  1 
ATOM   4844 C C   . GLY D 4 8   ? 13.030  -27.152 18.503  1.00 44.72  ? 8   GLY H C   1 
ATOM   4845 O O   . GLY D 4 8   ? 11.981  -26.584 18.198  1.00 52.33  ? 8   GLY H O   1 
ATOM   4846 N N   . THR D 4 9   ? 13.646  -28.018 17.700  1.00 44.88  ? 9   THR H N   1 
ATOM   4847 C CA  . THR D 4 9   ? 13.112  -28.359 16.387  1.00 49.61  ? 9   THR H CA  1 
ATOM   4848 C C   . THR D 4 9   ? 11.774  -29.078 16.524  1.00 42.66  ? 9   THR H C   1 
ATOM   4849 O O   . THR D 4 9   ? 11.592  -29.923 17.404  1.00 47.79  ? 9   THR H O   1 
ATOM   4850 C CB  . THR D 4 9   ? 14.111  -29.237 15.626  1.00 49.25  ? 9   THR H CB  1 
ATOM   4851 O OG1 . THR D 4 9   ? 15.355  -28.537 15.487  1.00 39.54  ? 9   THR H OG1 1 
ATOM   4852 C CG2 . THR D 4 9   ? 13.585  -29.602 14.244  1.00 42.17  ? 9   THR H CG2 1 
ATOM   4853 N N   . GLU D 4 10  ? 10.832  -28.734 15.647  1.00 45.88  ? 10  GLU H N   1 
ATOM   4854 C CA  . GLU D 4 10  ? 9.484   -29.287 15.671  1.00 52.50  ? 10  GLU H CA  1 
ATOM   4855 C C   . GLU D 4 10  ? 9.198   -30.018 14.366  1.00 53.79  ? 10  GLU H C   1 
ATOM   4856 O O   . GLU D 4 10  ? 9.474   -29.493 13.281  1.00 54.13  ? 10  GLU H O   1 
ATOM   4857 C CB  . GLU D 4 10  ? 8.444   -28.184 15.895  1.00 40.59  ? 10  GLU H CB  1 
ATOM   4858 C CG  . GLU D 4 10  ? 8.585   -27.440 17.214  1.00 50.71  ? 10  GLU H CG  1 
ATOM   4859 C CD  . GLU D 4 10  ? 7.972   -28.190 18.381  1.00 59.86  ? 10  GLU H CD  1 
ATOM   4860 O OE1 . GLU D 4 10  ? 7.449   -29.303 18.166  1.00 63.68  ? 10  GLU H OE1 1 
ATOM   4861 O OE2 . GLU D 4 10  ? 8.009   -27.663 19.514  1.00 56.21  ? 10  GLU H OE2 1 
ATOM   4862 N N   . VAL D 4 11  ? 8.650   -31.225 14.474  1.00 42.65  ? 11  VAL H N   1 
ATOM   4863 C CA  . VAL D 4 11  ? 8.184   -31.994 13.325  1.00 44.62  ? 11  VAL H CA  1 
ATOM   4864 C C   . VAL D 4 11  ? 6.728   -32.364 13.584  1.00 46.60  ? 11  VAL H C   1 
ATOM   4865 O O   . VAL D 4 11  ? 6.428   -33.060 14.562  1.00 48.80  ? 11  VAL H O   1 
ATOM   4866 C CB  . VAL D 4 11  ? 9.036   -33.250 13.086  1.00 45.45  ? 11  VAL H CB  1 
ATOM   4867 C CG1 . VAL D 4 11  ? 8.541   -34.006 11.858  1.00 37.18  ? 11  VAL H CG1 1 
ATOM   4868 C CG2 . VAL D 4 11  ? 10.504  -32.872 12.935  1.00 40.73  ? 11  VAL H CG2 1 
ATOM   4869 N N   . LYS D 4 12  ? 5.828   -31.894 12.721  1.00 41.96  ? 12  LYS H N   1 
ATOM   4870 C CA  . LYS D 4 12  ? 4.398   -32.051 12.937  1.00 40.14  ? 12  LYS H CA  1 
ATOM   4871 C C   . LYS D 4 12  ? 3.722   -32.481 11.642  1.00 48.36  ? 12  LYS H C   1 
ATOM   4872 O O   . LYS D 4 12  ? 4.214   -32.217 10.542  1.00 42.89  ? 12  LYS H O   1 
ATOM   4873 C CB  . LYS D 4 12  ? 3.753   -30.748 13.445  1.00 50.06  ? 12  LYS H CB  1 
ATOM   4874 C CG  . LYS D 4 12  ? 4.589   -29.954 14.446  1.00 50.93  ? 12  LYS H CG  1 
ATOM   4875 C CD  . LYS D 4 12  ? 4.604   -30.594 15.827  1.00 50.45  ? 12  LYS H CD  1 
ATOM   4876 C CE  . LYS D 4 12  ? 3.240   -30.511 16.491  1.00 52.08  ? 12  LYS H CE  1 
ATOM   4877 N NZ  . LYS D 4 12  ? 3.284   -31.014 17.891  1.00 47.84  ? 12  LYS H NZ  1 
ATOM   4878 N N   . LYS D 4 13  ? 2.580   -33.152 11.789  1.00 59.01  ? 13  LYS H N   1 
ATOM   4879 C CA  . LYS D 4 13  ? 1.740   -33.499 10.654  1.00 48.50  ? 13  LYS H CA  1 
ATOM   4880 C C   . LYS D 4 13  ? 0.843   -32.318 10.288  1.00 44.05  ? 13  LYS H C   1 
ATOM   4881 O O   . LYS D 4 13  ? 0.547   -31.472 11.136  1.00 56.40  ? 13  LYS H O   1 
ATOM   4882 C CB  . LYS D 4 13  ? 0.879   -34.717 10.974  1.00 44.22  ? 13  LYS H CB  1 
ATOM   4883 C CG  . LYS D 4 13  ? 1.645   -35.912 11.521  1.00 50.90  ? 13  LYS H CG  1 
ATOM   4884 C CD  . LYS D 4 13  ? 2.316   -36.711 10.418  1.00 48.85  ? 13  LYS H CD  1 
ATOM   4885 C CE  . LYS D 4 13  ? 3.140   -37.855 10.995  1.00 54.25  ? 13  LYS H CE  1 
ATOM   4886 N NZ  . LYS D 4 13  ? 2.347   -38.734 11.900  1.00 49.35  ? 13  LYS H NZ  1 
ATOM   4887 N N   . PRO D 4 14  ? 0.406   -32.231 9.032   1.00 47.32  ? 14  PRO H N   1 
ATOM   4888 C CA  . PRO D 4 14  ? -0.505  -31.146 8.647   1.00 44.57  ? 14  PRO H CA  1 
ATOM   4889 C C   . PRO D 4 14  ? -1.808  -31.207 9.430   1.00 56.34  ? 14  PRO H C   1 
ATOM   4890 O O   . PRO D 4 14  ? -2.334  -32.284 9.717   1.00 58.67  ? 14  PRO H O   1 
ATOM   4891 C CB  . PRO D 4 14  ? -0.736  -31.389 7.151   1.00 36.01  ? 14  PRO H CB  1 
ATOM   4892 C CG  . PRO D 4 14  ? 0.439   -32.191 6.711   1.00 52.22  ? 14  PRO H CG  1 
ATOM   4893 C CD  . PRO D 4 14  ? 0.800   -33.056 7.879   1.00 52.51  ? 14  PRO H CD  1 
ATOM   4894 N N   . GLY D 4 15  ? -2.327  -30.029 9.773   1.00 61.06  ? 15  GLY H N   1 
ATOM   4895 C CA  . GLY D 4 15  ? -3.542  -29.912 10.541  1.00 57.49  ? 15  GLY H CA  1 
ATOM   4896 C C   . GLY D 4 15  ? -3.345  -29.795 12.038  1.00 52.32  ? 15  GLY H C   1 
ATOM   4897 O O   . GLY D 4 15  ? -4.271  -29.366 12.737  1.00 64.25  ? 15  GLY H O   1 
ATOM   4898 N N   . GLU D 4 16  ? -2.170  -30.153 12.550  1.00 50.37  ? 16  GLU H N   1 
ATOM   4899 C CA  . GLU D 4 16  ? -1.896  -30.045 13.974  1.00 57.37  ? 16  GLU H CA  1 
ATOM   4900 C C   . GLU D 4 16  ? -1.638  -28.592 14.365  1.00 55.73  ? 16  GLU H C   1 
ATOM   4901 O O   . GLU D 4 16  ? -1.417  -27.717 13.523  1.00 57.97  ? 16  GLU H O   1 
ATOM   4902 C CB  . GLU D 4 16  ? -0.694  -30.907 14.367  1.00 67.98  ? 16  GLU H CB  1 
ATOM   4903 C CG  . GLU D 4 16  ? -0.852  -32.397 14.098  1.00 70.26  ? 16  GLU H CG  1 
ATOM   4904 C CD  . GLU D 4 16  ? 0.233   -33.230 14.764  1.00 75.60  ? 16  GLU H CD  1 
ATOM   4905 O OE1 . GLU D 4 16  ? 0.770   -32.793 15.805  1.00 82.99  ? 16  GLU H OE1 1 
ATOM   4906 O OE2 . GLU D 4 16  ? 0.550   -34.322 14.248  1.00 79.88  ? 16  GLU H OE2 1 
ATOM   4907 N N   . SER D 4 17  ? -1.671  -28.341 15.669  1.00 60.91  ? 17  SER H N   1 
ATOM   4908 C CA  . SER D 4 17  ? -1.327  -27.045 16.233  1.00 54.97  ? 17  SER H CA  1 
ATOM   4909 C C   . SER D 4 17  ? 0.132   -27.039 16.678  1.00 62.85  ? 17  SER H C   1 
ATOM   4910 O O   . SER D 4 17  ? 0.738   -28.084 16.928  1.00 58.03  ? 17  SER H O   1 
ATOM   4911 C CB  . SER D 4 17  ? -2.247  -26.697 17.408  1.00 47.11  ? 17  SER H CB  1 
ATOM   4912 O OG  . SER D 4 17  ? -2.206  -27.692 18.417  1.00 64.02  ? 17  SER H OG  1 
ATOM   4913 N N   . LEU D 4 18  ? 0.698   -25.837 16.761  1.00 60.08  ? 18  LEU H N   1 
ATOM   4914 C CA  . LEU D 4 18  ? 2.095   -25.680 17.135  1.00 52.73  ? 18  LEU H CA  1 
ATOM   4915 C C   . LEU D 4 18  ? 2.264   -24.381 17.909  1.00 54.13  ? 18  LEU H C   1 
ATOM   4916 O O   . LEU D 4 18  ? 1.581   -23.388 17.643  1.00 52.14  ? 18  LEU H O   1 
ATOM   4917 C CB  . LEU D 4 18  ? 3.010   -25.690 15.903  1.00 43.54  ? 18  LEU H CB  1 
ATOM   4918 C CG  . LEU D 4 18  ? 4.514   -25.592 16.165  1.00 44.22  ? 18  LEU H CG  1 
ATOM   4919 C CD1 . LEU D 4 18  ? 5.007   -26.795 16.959  1.00 41.66  ? 18  LEU H CD1 1 
ATOM   4920 C CD2 . LEU D 4 18  ? 5.274   -25.453 14.860  1.00 43.33  ? 18  LEU H CD2 1 
ATOM   4921 N N   . LYS D 4 19  ? 3.181   -24.403 18.876  1.00 55.28  ? 19  LYS H N   1 
ATOM   4922 C CA  . LYS D 4 19  ? 3.488   -23.215 19.671  1.00 47.13  ? 19  LYS H CA  1 
ATOM   4923 C C   . LYS D 4 19  ? 4.982   -23.254 19.982  1.00 51.10  ? 19  LYS H C   1 
ATOM   4924 O O   . LYS D 4 19  ? 5.418   -24.023 20.845  1.00 56.85  ? 19  LYS H O   1 
ATOM   4925 C CB  . LYS D 4 19  ? 2.647   -23.170 20.940  1.00 44.07  ? 19  LYS H CB  1 
ATOM   4926 C CG  . LYS D 4 19  ? 2.766   -21.879 21.738  1.00 51.10  ? 19  LYS H CG  1 
ATOM   4927 C CD  . LYS D 4 19  ? 1.826   -21.893 22.940  1.00 64.76  ? 19  LYS H CD  1 
ATOM   4928 C CE  . LYS D 4 19  ? 1.874   -20.580 23.713  1.00 66.86  ? 19  LYS H CE  1 
ATOM   4929 N NZ  . LYS D 4 19  ? 1.016   -20.599 24.935  1.00 60.85  ? 19  LYS H NZ  1 
ATOM   4930 N N   . ILE D 4 20  ? 5.754   -22.437 19.270  1.00 52.10  ? 20  ILE H N   1 
ATOM   4931 C CA  . ILE D 4 20  ? 7.188   -22.345 19.499  1.00 45.89  ? 20  ILE H CA  1 
ATOM   4932 C C   . ILE D 4 20  ? 7.463   -21.227 20.497  1.00 50.91  ? 20  ILE H C   1 
ATOM   4933 O O   . ILE D 4 20  ? 6.671   -20.297 20.666  1.00 48.14  ? 20  ILE H O   1 
ATOM   4934 C CB  . ILE D 4 20  ? 7.964   -22.124 18.187  1.00 36.38  ? 20  ILE H CB  1 
ATOM   4935 C CG1 . ILE D 4 20  ? 7.434   -20.898 17.450  1.00 43.93  ? 20  ILE H CG1 1 
ATOM   4936 C CG2 . ILE D 4 20  ? 7.864   -23.346 17.298  1.00 38.25  ? 20  ILE H CG2 1 
ATOM   4937 C CD1 . ILE D 4 20  ? 8.158   -20.629 16.156  1.00 41.24  ? 20  ILE H CD1 1 
ATOM   4938 N N   . SER D 4 21  ? 8.611   -21.315 21.162  1.00 56.90  ? 21  SER H N   1 
ATOM   4939 C CA  . SER D 4 21  ? 8.948   -20.429 22.263  1.00 46.98  ? 21  SER H CA  1 
ATOM   4940 C C   . SER D 4 21  ? 10.186  -19.602 21.930  1.00 54.15  ? 21  SER H C   1 
ATOM   4941 O O   . SER D 4 21  ? 10.980  -19.954 21.053  1.00 50.76  ? 21  SER H O   1 
ATOM   4942 C CB  . SER D 4 21  ? 9.174   -21.230 23.550  1.00 46.06  ? 21  SER H CB  1 
ATOM   4943 O OG  . SER D 4 21  ? 9.531   -20.380 24.619  1.00 58.89  ? 21  SER H OG  1 
ATOM   4944 N N   . CYS D 4 22  ? 10.332  -18.484 22.646  1.00 50.40  ? 22  CYS H N   1 
ATOM   4945 C CA  . CYS D 4 22  ? 11.473  -17.579 22.484  1.00 51.78  ? 22  CYS H CA  1 
ATOM   4946 C C   . CYS D 4 22  ? 11.655  -16.835 23.802  1.00 45.53  ? 22  CYS H C   1 
ATOM   4947 O O   . CYS D 4 22  ? 10.837  -15.975 24.140  1.00 57.44  ? 22  CYS H O   1 
ATOM   4948 C CB  . CYS D 4 22  ? 11.241  -16.606 21.326  1.00 63.37  ? 22  CYS H CB  1 
ATOM   4949 S SG  . CYS D 4 22  ? 12.431  -15.226 21.166  1.00 52.50  ? 22  CYS H SG  1 
ATOM   4950 N N   . LYS D 4 23  ? 12.715  -17.159 24.538  1.00 42.81  ? 23  LYS H N   1 
ATOM   4951 C CA  . LYS D 4 23  ? 12.959  -16.587 25.856  1.00 50.47  ? 23  LYS H CA  1 
ATOM   4952 C C   . LYS D 4 23  ? 14.200  -15.704 25.832  1.00 41.71  ? 23  LYS H C   1 
ATOM   4953 O O   . LYS D 4 23  ? 15.218  -16.061 25.230  1.00 42.65  ? 23  LYS H O   1 
ATOM   4954 C CB  . LYS D 4 23  ? 13.119  -17.685 26.910  1.00 50.11  ? 23  LYS H CB  1 
ATOM   4955 C CG  . LYS D 4 23  ? 13.246  -17.165 28.333  1.00 47.50  ? 23  LYS H CG  1 
ATOM   4956 C CD  . LYS D 4 23  ? 13.205  -18.302 29.339  1.00 61.18  ? 23  LYS H CD  1 
ATOM   4957 C CE  . LYS D 4 23  ? 13.233  -17.775 30.765  1.00 63.32  ? 23  LYS H CE  1 
ATOM   4958 N NZ  . LYS D 4 23  ? 13.098  -18.873 31.762  1.00 77.53  ? 23  LYS H NZ  1 
ATOM   4959 N N   . GLY D 4 24  ? 14.111  -14.552 26.491  1.00 45.60  ? 24  GLY H N   1 
ATOM   4960 C CA  . GLY D 4 24  ? 15.219  -13.619 26.522  1.00 52.24  ? 24  GLY H CA  1 
ATOM   4961 C C   . GLY D 4 24  ? 15.838  -13.459 27.895  1.00 51.57  ? 24  GLY H C   1 
ATOM   4962 O O   . GLY D 4 24  ? 15.190  -13.713 28.914  1.00 44.45  ? 24  GLY H O   1 
ATOM   4963 N N   . SER D 4 25  ? 17.099  -13.034 27.933  1.00 54.84  ? 25  SER H N   1 
ATOM   4964 C CA  . SER D 4 25  ? 17.799  -12.812 29.188  1.00 55.90  ? 25  SER H CA  1 
ATOM   4965 C C   . SER D 4 25  ? 18.861  -11.746 28.973  1.00 58.05  ? 25  SER H C   1 
ATOM   4966 O O   . SER D 4 25  ? 19.261  -11.460 27.842  1.00 61.80  ? 25  SER H O   1 
ATOM   4967 C CB  . SER D 4 25  ? 18.441  -14.099 29.710  1.00 53.55  ? 25  SER H CB  1 
ATOM   4968 O OG  . SER D 4 25  ? 19.418  -14.568 28.799  1.00 64.79  ? 25  SER H OG  1 
ATOM   4969 N N   . GLY D 4 26  ? 19.316  -11.156 30.081  1.00 52.15  ? 26  GLY H N   1 
ATOM   4970 C CA  . GLY D 4 26  ? 20.358  -10.148 30.054  1.00 62.64  ? 26  GLY H CA  1 
ATOM   4971 C C   . GLY D 4 26  ? 19.885  -8.850  30.694  1.00 65.91  ? 26  GLY H C   1 
ATOM   4972 O O   . GLY D 4 26  ? 19.204  -8.862  31.722  1.00 67.70  ? 26  GLY H O   1 
ATOM   4973 N N   . TYR D 4 27  ? 20.255  -7.734  30.070  1.00 64.28  ? 27  TYR H N   1 
ATOM   4974 C CA  . TYR D 4 27  ? 19.908  -6.409  30.559  1.00 65.67  ? 27  TYR H CA  1 
ATOM   4975 C C   . TYR D 4 27  ? 19.097  -5.659  29.512  1.00 67.95  ? 27  TYR H C   1 
ATOM   4976 O O   . TYR D 4 27  ? 19.309  -5.818  28.306  1.00 69.94  ? 27  TYR H O   1 
ATOM   4977 C CB  . TYR D 4 27  ? 21.160  -5.600  30.916  1.00 82.80  ? 27  TYR H CB  1 
ATOM   4978 C CG  . TYR D 4 27  ? 22.010  -6.227  32.000  1.00 101.23 ? 27  TYR H CG  1 
ATOM   4979 C CD1 . TYR D 4 27  ? 23.031  -7.114  31.683  1.00 91.30  ? 27  TYR H CD1 1 
ATOM   4980 C CD2 . TYR D 4 27  ? 21.792  -5.931  33.340  1.00 93.05  ? 27  TYR H CD2 1 
ATOM   4981 C CE1 . TYR D 4 27  ? 23.811  -7.690  32.670  1.00 88.40  ? 27  TYR H CE1 1 
ATOM   4982 C CE2 . TYR D 4 27  ? 22.568  -6.501  34.334  1.00 100.83 ? 27  TYR H CE2 1 
ATOM   4983 C CZ  . TYR D 4 27  ? 23.575  -7.380  33.994  1.00 100.67 ? 27  TYR H CZ  1 
ATOM   4984 O OH  . TYR D 4 27  ? 24.349  -7.950  34.981  1.00 89.20  ? 27  TYR H OH  1 
ATOM   4985 N N   . GLY D 4 28  ? 18.167  -4.834  29.987  1.00 67.27  ? 28  GLY H N   1 
ATOM   4986 C CA  . GLY D 4 28  ? 17.333  -4.055  29.096  1.00 52.03  ? 28  GLY H CA  1 
ATOM   4987 C C   . GLY D 4 28  ? 16.138  -4.785  28.537  1.00 51.29  ? 28  GLY H C   1 
ATOM   4988 O O   . GLY D 4 28  ? 15.624  -4.386  27.488  1.00 48.26  ? 28  GLY H O   1 
ATOM   4989 N N   . LEU D 4 29  ? 15.673  -5.842  29.210  1.00 50.46  ? 29  LEU H N   1 
ATOM   4990 C CA  . LEU D 4 29  ? 14.547  -6.615  28.695  1.00 53.44  ? 29  LEU H CA  1 
ATOM   4991 C C   . LEU D 4 29  ? 13.305  -5.755  28.514  1.00 48.83  ? 29  LEU H C   1 
ATOM   4992 O O   . LEU D 4 29  ? 12.520  -5.987  27.586  1.00 46.25  ? 29  LEU H O   1 
ATOM   4993 C CB  . LEU D 4 29  ? 14.235  -7.785  29.630  1.00 60.03  ? 29  LEU H CB  1 
ATOM   4994 C CG  . LEU D 4 29  ? 15.090  -9.053  29.549  1.00 63.59  ? 29  LEU H CG  1 
ATOM   4995 C CD1 . LEU D 4 29  ? 15.114  -9.590  28.130  1.00 51.96  ? 29  LEU H CD1 1 
ATOM   4996 C CD2 . LEU D 4 29  ? 16.502  -8.818  30.065  1.00 69.53  ? 29  LEU H CD2 1 
ATOM   4997 N N   . ILE D 4 30  ? 13.113  -4.758  29.383  1.00 37.16  ? 30  ILE H N   1 
ATOM   4998 C CA  . ILE D 4 30  ? 11.898  -3.952  29.363  1.00 35.69  ? 30  ILE H CA  1 
ATOM   4999 C C   . ILE D 4 30  ? 11.783  -3.141  28.081  1.00 43.06  ? 30  ILE H C   1 
ATOM   5000 O O   . ILE D 4 30  ? 10.673  -2.776  27.675  1.00 42.97  ? 30  ILE H O   1 
ATOM   5001 C CB  . ILE D 4 30  ? 11.854  -3.042  30.612  1.00 31.06  ? 30  ILE H CB  1 
ATOM   5002 C CG1 . ILE D 4 30  ? 10.480  -2.387  30.763  1.00 34.40  ? 30  ILE H CG1 1 
ATOM   5003 C CG2 . ILE D 4 30  ? 12.949  -1.986  30.554  1.00 22.98  ? 30  ILE H CG2 1 
ATOM   5004 C CD1 . ILE D 4 30  ? 9.348   -3.368  30.936  1.00 35.19  ? 30  ILE H CD1 1 
ATOM   5005 N N   . THR D 4 31  ? 12.904  -2.852  27.423  1.00 30.19  ? 31  THR H N   1 
ATOM   5006 C CA  . THR D 4 31  ? 12.876  -2.027  26.226  1.00 38.78  ? 31  THR H CA  1 
ATOM   5007 C C   . THR D 4 31  ? 12.712  -2.830  24.945  1.00 43.33  ? 31  THR H C   1 
ATOM   5008 O O   . THR D 4 31  ? 12.360  -2.249  23.913  1.00 55.44  ? 31  THR H O   1 
ATOM   5009 C CB  . THR D 4 31  ? 14.156  -1.185  26.127  1.00 41.28  ? 31  THR H CB  1 
ATOM   5010 O OG1 . THR D 4 31  ? 15.270  -2.027  25.805  1.00 41.19  ? 31  THR H OG1 1 
ATOM   5011 C CG2 . THR D 4 31  ? 14.431  -0.474  27.444  1.00 40.78  ? 31  THR H CG2 1 
ATOM   5012 N N   . TYR D 4 32  ? 12.935  -4.140  24.978  1.00 40.15  ? 32  TYR H N   1 
ATOM   5013 C CA  . TYR D 4 32  ? 13.078  -4.908  23.746  1.00 41.37  ? 32  TYR H CA  1 
ATOM   5014 C C   . TYR D 4 32  ? 11.721  -5.345  23.206  1.00 42.15  ? 32  TYR H C   1 
ATOM   5015 O O   . TYR D 4 32  ? 10.941  -5.999  23.909  1.00 40.86  ? 32  TYR H O   1 
ATOM   5016 C CB  . TYR D 4 32  ? 13.987  -6.115  23.970  1.00 40.01  ? 32  TYR H CB  1 
ATOM   5017 C CG  . TYR D 4 32  ? 15.440  -5.805  23.699  1.00 39.78  ? 32  TYR H CG  1 
ATOM   5018 C CD1 . TYR D 4 32  ? 15.945  -5.832  22.406  1.00 37.21  ? 32  TYR H CD1 1 
ATOM   5019 C CD2 . TYR D 4 32  ? 16.302  -5.465  24.731  1.00 45.05  ? 32  TYR H CD2 1 
ATOM   5020 C CE1 . TYR D 4 32  ? 17.271  -5.537  22.151  1.00 39.88  ? 32  TYR H CE1 1 
ATOM   5021 C CE2 . TYR D 4 32  ? 17.629  -5.170  24.487  1.00 45.96  ? 32  TYR H CE2 1 
ATOM   5022 C CZ  . TYR D 4 32  ? 18.109  -5.208  23.196  1.00 45.82  ? 32  TYR H CZ  1 
ATOM   5023 O OH  . TYR D 4 32  ? 19.431  -4.915  22.953  1.00 50.71  ? 32  TYR H OH  1 
ATOM   5024 N N   . TRP D 4 33  ? 11.443  -4.971  21.957  1.00 42.53  ? 33  TRP H N   1 
ATOM   5025 C CA  . TRP D 4 33  ? 10.316  -5.502  21.203  1.00 38.38  ? 33  TRP H CA  1 
ATOM   5026 C C   . TRP D 4 33  ? 10.747  -6.782  20.499  1.00 42.63  ? 33  TRP H C   1 
ATOM   5027 O O   . TRP D 4 33  ? 11.832  -6.848  19.913  1.00 38.92  ? 33  TRP H O   1 
ATOM   5028 C CB  . TRP D 4 33  ? 9.815   -4.488  20.168  1.00 37.61  ? 33  TRP H CB  1 
ATOM   5029 C CG  . TRP D 4 33  ? 9.208   -3.231  20.735  1.00 32.99  ? 33  TRP H CG  1 
ATOM   5030 C CD1 . TRP D 4 33  ? 9.816   -2.329  21.554  1.00 40.26  ? 33  TRP H CD1 1 
ATOM   5031 C CD2 . TRP D 4 33  ? 7.885   -2.724  20.495  1.00 40.15  ? 33  TRP H CD2 1 
ATOM   5032 N NE1 . TRP D 4 33  ? 8.955   -1.301  21.853  1.00 42.21  ? 33  TRP H NE1 1 
ATOM   5033 C CE2 . TRP D 4 33  ? 7.763   -1.520  21.215  1.00 39.36  ? 33  TRP H CE2 1 
ATOM   5034 C CE3 . TRP D 4 33  ? 6.791   -3.177  19.748  1.00 50.91  ? 33  TRP H CE3 1 
ATOM   5035 C CZ2 . TRP D 4 33  ? 6.593   -0.760  21.211  1.00 48.21  ? 33  TRP H CZ2 1 
ATOM   5036 C CZ3 . TRP D 4 33  ? 5.626   -2.419  19.746  1.00 35.83  ? 33  TRP H CZ3 1 
ATOM   5037 C CH2 . TRP D 4 33  ? 5.539   -1.226  20.472  1.00 33.43  ? 33  TRP H CH2 1 
ATOM   5038 N N   . ILE D 4 34  ? 9.888   -7.797  20.546  1.00 39.40  ? 34  ILE H N   1 
ATOM   5039 C CA  . ILE D 4 34  ? 10.216  -9.120  20.026  1.00 40.33  ? 34  ILE H CA  1 
ATOM   5040 C C   . ILE D 4 34  ? 9.480   -9.332  18.711  1.00 36.26  ? 34  ILE H C   1 
ATOM   5041 O O   . ILE D 4 34  ? 8.243   -9.322  18.671  1.00 36.89  ? 34  ILE H O   1 
ATOM   5042 C CB  . ILE D 4 34  ? 9.869   -10.227 21.031  1.00 35.17  ? 34  ILE H CB  1 
ATOM   5043 C CG1 . ILE D 4 34  ? 10.528  -9.929  22.375  1.00 31.92  ? 34  ILE H CG1 1 
ATOM   5044 C CG2 . ILE D 4 34  ? 10.322  -11.576 20.494  1.00 29.27  ? 34  ILE H CG2 1 
ATOM   5045 C CD1 . ILE D 4 34  ? 12.016  -9.679  22.272  1.00 28.03  ? 34  ILE H CD1 1 
ATOM   5046 N N   . GLY D 4 35  ? 10.245  -9.541  17.638  1.00 38.65  ? 35  GLY H N   1 
ATOM   5047 C CA  . GLY D 4 35  ? 9.690   -9.830  16.336  1.00 35.13  ? 35  GLY H CA  1 
ATOM   5048 C C   . GLY D 4 35  ? 9.788   -11.307 15.984  1.00 44.40  ? 35  GLY H C   1 
ATOM   5049 O O   . GLY D 4 35  ? 10.309  -12.130 16.733  1.00 45.43  ? 35  GLY H O   1 
ATOM   5050 N N   . TRP D 4 36  ? 9.263   -11.634 14.806  1.00 39.47  ? 36  TRP H N   1 
ATOM   5051 C CA  . TRP D 4 36  ? 9.268   -13.003 14.311  1.00 30.02  ? 36  TRP H CA  1 
ATOM   5052 C C   . TRP D 4 36  ? 9.472   -12.989 12.805  1.00 36.60  ? 36  TRP H C   1 
ATOM   5053 O O   . TRP D 4 36  ? 8.704   -12.350 12.080  1.00 43.95  ? 36  TRP H O   1 
ATOM   5054 C CB  . TRP D 4 36  ? 7.964   -13.728 14.660  1.00 35.40  ? 36  TRP H CB  1 
ATOM   5055 C CG  . TRP D 4 36  ? 7.850   -14.159 16.095  1.00 37.30  ? 36  TRP H CG  1 
ATOM   5056 C CD1 . TRP D 4 36  ? 7.155   -13.531 17.086  1.00 41.07  ? 36  TRP H CD1 1 
ATOM   5057 C CD2 . TRP D 4 36  ? 8.439   -15.322 16.694  1.00 38.89  ? 36  TRP H CD2 1 
ATOM   5058 N NE1 . TRP D 4 36  ? 7.276   -14.227 18.265  1.00 36.42  ? 36  TRP H NE1 1 
ATOM   5059 C CE2 . TRP D 4 36  ? 8.060   -15.330 18.051  1.00 36.98  ? 36  TRP H CE2 1 
ATOM   5060 C CE3 . TRP D 4 36  ? 9.253   -16.355 16.215  1.00 41.31  ? 36  TRP H CE3 1 
ATOM   5061 C CZ2 . TRP D 4 36  ? 8.465   -16.329 18.935  1.00 42.46  ? 36  TRP H CZ2 1 
ATOM   5062 C CZ3 . TRP D 4 36  ? 9.655   -17.347 17.095  1.00 36.87  ? 36  TRP H CZ3 1 
ATOM   5063 C CH2 . TRP D 4 36  ? 9.260   -17.326 18.438  1.00 39.04  ? 36  TRP H CH2 1 
ATOM   5064 N N   . VAL D 4 37  ? 10.496  -13.707 12.343  1.00 34.51  ? 37  VAL H N   1 
ATOM   5065 C CA  . VAL D 4 37  ? 10.898  -13.722 10.942  1.00 29.23  ? 37  VAL H CA  1 
ATOM   5066 C C   . VAL D 4 37  ? 10.873  -15.157 10.440  1.00 29.62  ? 37  VAL H C   1 
ATOM   5067 O O   . VAL D 4 37  ? 11.475  -16.047 11.052  1.00 39.23  ? 37  VAL H O   1 
ATOM   5068 C CB  . VAL D 4 37  ? 12.295  -13.103 10.748  1.00 32.64  ? 37  VAL H CB  1 
ATOM   5069 C CG1 . VAL D 4 37  ? 12.774  -13.288 9.311   1.00 31.60  ? 37  VAL H CG1 1 
ATOM   5070 C CG2 . VAL D 4 37  ? 12.275  -11.632 11.130  1.00 27.94  ? 37  VAL H CG2 1 
ATOM   5071 N N   . ARG D 4 38  ? 10.189  -15.374 9.320   1.00 40.51  ? 38  ARG H N   1 
ATOM   5072 C CA  . ARG D 4 38  ? 10.116  -16.674 8.672   1.00 34.15  ? 38  ARG H CA  1 
ATOM   5073 C C   . ARG D 4 38  ? 11.077  -16.718 7.496   1.00 35.87  ? 38  ARG H C   1 
ATOM   5074 O O   . ARG D 4 38  ? 11.147  -15.775 6.702   1.00 47.86  ? 38  ARG H O   1 
ATOM   5075 C CB  . ARG D 4 38  ? 8.699   -16.970 8.179   1.00 38.26  ? 38  ARG H CB  1 
ATOM   5076 C CG  . ARG D 4 38  ? 8.563   -18.324 7.510   1.00 35.12  ? 38  ARG H CG  1 
ATOM   5077 C CD  . ARG D 4 38  ? 7.141   -18.594 7.079   1.00 35.76  ? 38  ARG H CD  1 
ATOM   5078 N NE  . ARG D 4 38  ? 6.808   -17.895 5.846   1.00 45.47  ? 38  ARG H NE  1 
ATOM   5079 C CZ  . ARG D 4 38  ? 5.685   -18.076 5.167   1.00 54.25  ? 38  ARG H CZ  1 
ATOM   5080 N NH1 . ARG D 4 38  ? 4.759   -18.929 5.578   1.00 36.26  ? 38  ARG H NH1 1 
ATOM   5081 N NH2 . ARG D 4 38  ? 5.486   -17.388 4.045   1.00 48.73  ? 38  ARG H NH2 1 
ATOM   5082 N N   . GLN D 4 39  ? 11.807  -17.820 7.378   1.00 38.23  ? 39  GLN H N   1 
ATOM   5083 C CA  . GLN D 4 39  ? 12.742  -18.014 6.274   1.00 36.21  ? 39  GLN H CA  1 
ATOM   5084 C C   . GLN D 4 39  ? 12.544  -19.421 5.724   1.00 41.56  ? 39  GLN H C   1 
ATOM   5085 O O   . GLN D 4 39  ? 12.999  -20.398 6.325   1.00 40.30  ? 39  GLN H O   1 
ATOM   5086 C CB  . GLN D 4 39  ? 14.174  -17.792 6.732   1.00 34.10  ? 39  GLN H CB  1 
ATOM   5087 C CG  . GLN D 4 39  ? 15.193  -17.893 5.626   1.00 36.13  ? 39  GLN H CG  1 
ATOM   5088 C CD  . GLN D 4 39  ? 16.600  -17.786 6.155   1.00 39.87  ? 39  GLN H CD  1 
ATOM   5089 O OE1 . GLN D 4 39  ? 17.442  -17.105 5.574   1.00 47.49  ? 39  GLN H OE1 1 
ATOM   5090 N NE2 . GLN D 4 39  ? 16.866  -18.461 7.269   1.00 34.15  ? 39  GLN H NE2 1 
ATOM   5091 N N   . MET D 4 40  ? 11.852  -19.527 4.595   1.00 47.18  ? 40  MET H N   1 
ATOM   5092 C CA  . MET D 4 40  ? 11.722  -20.817 3.940   1.00 41.40  ? 40  MET H CA  1 
ATOM   5093 C C   . MET D 4 40  ? 13.053  -21.223 3.314   1.00 51.04  ? 40  MET H C   1 
ATOM   5094 O O   . MET D 4 40  ? 13.904  -20.385 2.999   1.00 53.79  ? 40  MET H O   1 
ATOM   5095 C CB  . MET D 4 40  ? 10.613  -20.779 2.890   1.00 43.99  ? 40  MET H CB  1 
ATOM   5096 C CG  . MET D 4 40  ? 9.225   -20.596 3.488   1.00 42.91  ? 40  MET H CG  1 
ATOM   5097 S SD  . MET D 4 40  ? 7.898   -20.581 2.267   1.00 62.25  ? 40  MET H SD  1 
ATOM   5098 C CE  . MET D 4 40  ? 8.221   -19.045 1.403   1.00 57.77  ? 40  MET H CE  1 
ATOM   5099 N N   . SER D 4 41  ? 13.230  -22.533 3.149   1.00 47.42  ? 41  SER H N   1 
ATOM   5100 C CA  . SER D 4 41  ? 14.509  -23.076 2.705   1.00 41.40  ? 41  SER H CA  1 
ATOM   5101 C C   . SER D 4 41  ? 14.878  -22.535 1.331   1.00 47.84  ? 41  SER H C   1 
ATOM   5102 O O   . SER D 4 41  ? 14.121  -22.688 0.367   1.00 42.26  ? 41  SER H O   1 
ATOM   5103 C CB  . SER D 4 41  ? 14.447  -24.603 2.677   1.00 45.35  ? 41  SER H CB  1 
ATOM   5104 O OG  . SER D 4 41  ? 15.691  -25.157 2.282   1.00 49.25  ? 41  SER H OG  1 
ATOM   5105 N N   . GLY D 4 42  ? 16.049  -21.904 1.248   1.00 48.20  ? 42  GLY H N   1 
ATOM   5106 C CA  . GLY D 4 42  ? 16.539  -21.354 0.002   1.00 53.22  ? 42  GLY H CA  1 
ATOM   5107 C C   . GLY D 4 42  ? 15.977  -20.004 -0.379  1.00 60.42  ? 42  GLY H C   1 
ATOM   5108 O O   . GLY D 4 42  ? 16.224  -19.545 -1.500  1.00 70.62  ? 42  GLY H O   1 
ATOM   5109 N N   . LYS D 4 43  ? 15.230  -19.354 0.506   1.00 58.41  ? 43  LYS H N   1 
ATOM   5110 C CA  . LYS D 4 43  ? 14.607  -18.070 0.216   1.00 58.88  ? 43  LYS H CA  1 
ATOM   5111 C C   . LYS D 4 43  ? 15.066  -17.032 1.242   1.00 58.97  ? 43  LYS H C   1 
ATOM   5112 O O   . LYS D 4 43  ? 15.942  -17.289 2.074   1.00 43.15  ? 43  LYS H O   1 
ATOM   5113 C CB  . LYS D 4 43  ? 13.084  -18.214 0.181   1.00 47.96  ? 43  LYS H CB  1 
ATOM   5114 C CG  . LYS D 4 43  ? 12.588  -19.214 -0.853  1.00 47.91  ? 43  LYS H CG  1 
ATOM   5115 C CD  . LYS D 4 43  ? 11.074  -19.342 -0.823  1.00 77.32  ? 43  LYS H CD  1 
ATOM   5116 C CE  . LYS D 4 43  ? 10.586  -20.405 -1.797  1.00 71.83  ? 43  LYS H CE  1 
ATOM   5117 N NZ  . LYS D 4 43  ? 9.103   -20.552 -1.766  1.00 67.08  ? 43  LYS H NZ  1 
ATOM   5118 N N   . GLY D 4 44  ? 14.464  -15.848 1.172   1.00 44.58  ? 44  GLY H N   1 
ATOM   5119 C CA  . GLY D 4 44  ? 14.858  -14.724 1.994   1.00 42.84  ? 44  GLY H CA  1 
ATOM   5120 C C   . GLY D 4 44  ? 14.135  -14.681 3.324   1.00 48.65  ? 44  GLY H C   1 
ATOM   5121 O O   . GLY D 4 44  ? 13.584  -15.676 3.800   1.00 52.98  ? 44  GLY H O   1 
ATOM   5122 N N   . LEU D 4 45  ? 14.134  -13.494 3.924   1.00 37.14  ? 45  LEU H N   1 
ATOM   5123 C CA  . LEU D 4 45  ? 13.566  -13.278 5.247   1.00 35.69  ? 45  LEU H CA  1 
ATOM   5124 C C   . LEU D 4 45  ? 12.222  -12.570 5.126   1.00 45.83  ? 45  LEU H C   1 
ATOM   5125 O O   . LEU D 4 45  ? 12.119  -11.539 4.455   1.00 52.54  ? 45  LEU H O   1 
ATOM   5126 C CB  . LEU D 4 45  ? 14.515  -12.451 6.113   1.00 33.57  ? 45  LEU H CB  1 
ATOM   5127 C CG  . LEU D 4 45  ? 15.933  -13.002 6.254   1.00 46.44  ? 45  LEU H CG  1 
ATOM   5128 C CD1 . LEU D 4 45  ? 16.788  -12.036 7.053   1.00 34.72  ? 45  LEU H CD1 1 
ATOM   5129 C CD2 . LEU D 4 45  ? 15.919  -14.381 6.902   1.00 43.19  ? 45  LEU H CD2 1 
ATOM   5130 N N   . GLU D 4 46  ? 11.200  -13.123 5.774   1.00 37.87  ? 46  GLU H N   1 
ATOM   5131 C CA  . GLU D 4 46  ? 9.858   -12.558 5.757   1.00 36.61  ? 46  GLU H CA  1 
ATOM   5132 C C   . GLU D 4 46  ? 9.493   -12.115 7.167   1.00 44.76  ? 46  GLU H C   1 
ATOM   5133 O O   . GLU D 4 46  ? 9.527   -12.920 8.103   1.00 43.83  ? 46  GLU H O   1 
ATOM   5134 C CB  . GLU D 4 46  ? 8.833   -13.571 5.242   1.00 36.79  ? 46  GLU H CB  1 
ATOM   5135 C CG  . GLU D 4 46  ? 9.281   -14.394 4.048   1.00 56.08  ? 46  GLU H CG  1 
ATOM   5136 C CD  . GLU D 4 46  ? 8.286   -15.489 3.695   1.00 61.84  ? 46  GLU H CD  1 
ATOM   5137 O OE1 . GLU D 4 46  ? 7.066   -15.215 3.707   1.00 41.76  ? 46  GLU H OE1 1 
ATOM   5138 O OE2 . GLU D 4 46  ? 8.723   -16.627 3.418   1.00 66.39  ? 46  GLU H OE2 1 
ATOM   5139 N N   . TRP D 4 47  ? 9.118   -10.849 7.315   1.00 43.05  ? 47  TRP H N   1 
ATOM   5140 C CA  . TRP D 4 47  ? 8.688   -10.343 8.610   1.00 37.52  ? 47  TRP H CA  1 
ATOM   5141 C C   . TRP D 4 47  ? 7.212   -10.656 8.815   1.00 37.48  ? 47  TRP H C   1 
ATOM   5142 O O   . TRP D 4 47  ? 6.383   -10.374 7.945   1.00 52.33  ? 47  TRP H O   1 
ATOM   5143 C CB  . TRP D 4 47  ? 8.935   -8.840  8.698   1.00 46.43  ? 47  TRP H CB  1 
ATOM   5144 C CG  . TRP D 4 47  ? 8.699   -8.262  10.056  1.00 42.78  ? 47  TRP H CG  1 
ATOM   5145 C CD1 . TRP D 4 47  ? 9.572   -8.249  11.099  1.00 37.16  ? 47  TRP H CD1 1 
ATOM   5146 C CD2 . TRP D 4 47  ? 7.518   -7.594  10.511  1.00 42.18  ? 47  TRP H CD2 1 
ATOM   5147 N NE1 . TRP D 4 47  ? 9.009   -7.619  12.181  1.00 40.60  ? 47  TRP H NE1 1 
ATOM   5148 C CE2 . TRP D 4 47  ? 7.746   -7.208  11.845  1.00 38.55  ? 47  TRP H CE2 1 
ATOM   5149 C CE3 . TRP D 4 47  ? 6.287   -7.289  9.921   1.00 51.58  ? 47  TRP H CE3 1 
ATOM   5150 C CZ2 . TRP D 4 47  ? 6.792   -6.530  12.599  1.00 36.66  ? 47  TRP H CZ2 1 
ATOM   5151 C CZ3 . TRP D 4 47  ? 5.340   -6.619  10.672  1.00 51.40  ? 47  TRP H CZ3 1 
ATOM   5152 C CH2 . TRP D 4 47  ? 5.597   -6.246  11.997  1.00 47.54  ? 47  TRP H CH2 1 
ATOM   5153 N N   . MET D 4 48  ? 6.883   -11.242 9.963   1.00 32.74  ? 48  MET H N   1 
ATOM   5154 C CA  . MET D 4 48  ? 5.513   -11.653 10.250  1.00 39.86  ? 48  MET H CA  1 
ATOM   5155 C C   . MET D 4 48  ? 4.807   -10.772 11.266  1.00 48.17  ? 48  MET H C   1 
ATOM   5156 O O   . MET D 4 48  ? 3.627   -10.466 11.088  1.00 54.88  ? 48  MET H O   1 
ATOM   5157 C CB  . MET D 4 48  ? 5.488   -13.100 10.747  1.00 41.38  ? 48  MET H CB  1 
ATOM   5158 C CG  . MET D 4 48  ? 6.233   -14.072 9.852   1.00 46.72  ? 48  MET H CG  1 
ATOM   5159 S SD  . MET D 4 48  ? 6.124   -15.765 10.470  1.00 49.23  ? 48  MET H SD  1 
ATOM   5160 C CE  . MET D 4 48  ? 6.132   -15.470 12.222  1.00 29.18  ? 48  MET H CE  1 
ATOM   5161 N N   . GLY D 4 49  ? 5.491   -10.363 12.327  1.00 55.47  ? 49  GLY H N   1 
ATOM   5162 C CA  . GLY D 4 49  ? 4.850   -9.552  13.346  1.00 44.43  ? 49  GLY H CA  1 
ATOM   5163 C C   . GLY D 4 49  ? 5.841   -9.143  14.413  1.00 36.20  ? 49  GLY H C   1 
ATOM   5164 O O   . GLY D 4 49  ? 7.010   -9.542  14.402  1.00 41.24  ? 49  GLY H O   1 
ATOM   5165 N N   . ILE D 4 50  ? 5.345   -8.324  15.343  1.00 33.74  ? 50  ILE H N   1 
ATOM   5166 C CA  . ILE D 4 50  ? 6.139   -7.801  16.448  1.00 31.03  ? 50  ILE H CA  1 
ATOM   5167 C C   . ILE D 4 50  ? 5.219   -7.648  17.649  1.00 34.56  ? 50  ILE H C   1 
ATOM   5168 O O   . ILE D 4 50  ? 3.999   -7.542  17.509  1.00 43.71  ? 50  ILE H O   1 
ATOM   5169 C CB  . ILE D 4 50  ? 6.799   -6.450  16.093  1.00 34.63  ? 50  ILE H CB  1 
ATOM   5170 C CG1 . ILE D 4 50  ? 7.939   -6.129  17.058  1.00 30.05  ? 50  ILE H CG1 1 
ATOM   5171 C CG2 . ILE D 4 50  ? 5.760   -5.343  16.106  1.00 31.48  ? 50  ILE H CG2 1 
ATOM   5172 C CD1 . ILE D 4 50  ? 8.640   -4.834  16.748  1.00 29.10  ? 50  ILE H CD1 1 
ATOM   5173 N N   . ILE D 4 51  ? 5.810   -7.638  18.842  1.00 31.74  ? 51  ILE H N   1 
ATOM   5174 C CA  . ILE D 4 51  ? 5.039   -7.501  20.074  1.00 38.86  ? 51  ILE H CA  1 
ATOM   5175 C C   . ILE D 4 51  ? 5.911   -6.863  21.147  1.00 37.44  ? 51  ILE H C   1 
ATOM   5176 O O   . ILE D 4 51  ? 7.089   -7.203  21.294  1.00 42.32  ? 51  ILE H O   1 
ATOM   5177 C CB  . ILE D 4 51  ? 4.484   -8.864  20.543  1.00 41.85  ? 51  ILE H CB  1 
ATOM   5178 C CG1 . ILE D 4 51  ? 3.892   -8.748  21.951  1.00 39.48  ? 51  ILE H CG1 1 
ATOM   5179 C CG2 . ILE D 4 51  ? 5.570   -9.928  20.504  1.00 30.46  ? 51  ILE H CG2 1 
ATOM   5180 C CD1 . ILE D 4 51  ? 2.917   -9.852  22.295  1.00 43.24  ? 51  ILE H CD1 1 
ATOM   5181 N N   . TYR D 4 52  ? 5.320   -5.935  21.906  1.00 41.70  ? 52  TYR H N   1 
ATOM   5182 C CA  . TYR D 4 52  ? 5.972   -5.379  23.081  1.00 41.50  ? 52  TYR H CA  1 
ATOM   5183 C C   . TYR D 4 52  ? 5.479   -6.144  24.301  1.00 42.64  ? 52  TYR H C   1 
ATOM   5184 O O   . TYR D 4 52  ? 4.312   -5.983  24.689  1.00 35.37  ? 52  TYR H O   1 
ATOM   5185 C CB  . TYR D 4 52  ? 5.669   -3.886  23.220  1.00 32.32  ? 52  TYR H CB  1 
ATOM   5186 C CG  . TYR D 4 52  ? 6.429   -3.224  24.347  1.00 42.37  ? 52  TYR H CG  1 
ATOM   5187 C CD1 . TYR D 4 52  ? 7.811   -3.094  24.295  1.00 43.33  ? 52  TYR H CD1 1 
ATOM   5188 C CD2 . TYR D 4 52  ? 5.768   -2.737  25.466  1.00 42.73  ? 52  TYR H CD2 1 
ATOM   5189 C CE1 . TYR D 4 52  ? 8.514   -2.498  25.326  1.00 42.26  ? 52  TYR H CE1 1 
ATOM   5190 C CE2 . TYR D 4 52  ? 6.464   -2.136  26.502  1.00 39.30  ? 52  TYR H CE2 1 
ATOM   5191 C CZ  . TYR D 4 52  ? 7.836   -2.020  26.428  1.00 42.02  ? 52  TYR H CZ  1 
ATOM   5192 O OH  . TYR D 4 52  ? 8.530   -1.423  27.458  1.00 41.54  ? 52  TYR H OH  1 
ATOM   5193 N N   . PRO D 4 53  A 6.317   -6.972  24.935  1.00 39.09  ? 52  PRO H N   1 
ATOM   5194 C CA  . PRO D 4 53  A 5.800   -7.930  25.930  1.00 31.84  ? 52  PRO H CA  1 
ATOM   5195 C C   . PRO D 4 53  A 5.137   -7.301  27.147  1.00 36.62  ? 52  PRO H C   1 
ATOM   5196 O O   . PRO D 4 53  A 4.253   -7.930  27.742  1.00 51.43  ? 52  PRO H O   1 
ATOM   5197 C CB  . PRO D 4 53  A 7.052   -8.726  26.325  1.00 35.16  ? 52  PRO H CB  1 
ATOM   5198 C CG  . PRO D 4 53  A 7.992   -8.566  25.170  1.00 27.92  ? 52  PRO H CG  1 
ATOM   5199 C CD  . PRO D 4 53  A 7.749   -7.177  24.661  1.00 47.35  ? 52  PRO H CD  1 
ATOM   5200 N N   . ALA D 4 54  ? 5.533   -6.086  27.540  1.00 36.78  ? 53  ALA H N   1 
ATOM   5201 C CA  . ALA D 4 54  ? 5.041   -5.521  28.796  1.00 37.11  ? 53  ALA H CA  1 
ATOM   5202 C C   . ALA D 4 54  ? 3.529   -5.318  28.774  1.00 40.40  ? 53  ALA H C   1 
ATOM   5203 O O   . ALA D 4 54  ? 2.848   -5.580  29.772  1.00 56.19  ? 53  ALA H O   1 
ATOM   5204 C CB  . ALA D 4 54  ? 5.754   -4.203  29.098  1.00 33.48  ? 53  ALA H CB  1 
ATOM   5205 N N   . ASP D 4 55  ? 2.983   -4.844  27.654  1.00 43.55  ? 54  ASP H N   1 
ATOM   5206 C CA  . ASP D 4 55  ? 1.541   -4.666  27.521  1.00 42.36  ? 54  ASP H CA  1 
ATOM   5207 C C   . ASP D 4 55  ? 0.958   -5.457  26.358  1.00 41.68  ? 54  ASP H C   1 
ATOM   5208 O O   . ASP D 4 55  ? -0.230  -5.300  26.050  1.00 43.56  ? 54  ASP H O   1 
ATOM   5209 C CB  . ASP D 4 55  ? 1.185   -3.182  27.382  1.00 46.27  ? 54  ASP H CB  1 
ATOM   5210 C CG  . ASP D 4 55  ? 1.847   -2.518  26.185  1.00 55.46  ? 54  ASP H CG  1 
ATOM   5211 O OD1 . ASP D 4 55  ? 2.570   -3.192  25.418  1.00 53.68  ? 54  ASP H OD1 1 
ATOM   5212 O OD2 . ASP D 4 55  ? 1.637   -1.300  26.018  1.00 58.92  ? 54  ASP H OD2 1 
ATOM   5213 N N   . SER D 4 56  ? 1.767   -6.288  25.701  1.00 45.62  ? 55  SER H N   1 
ATOM   5214 C CA  . SER D 4 56  ? 1.307   -7.196  24.650  1.00 38.07  ? 55  SER H CA  1 
ATOM   5215 C C   . SER D 4 56  ? 0.697   -6.449  23.466  1.00 41.08  ? 55  SER H C   1 
ATOM   5216 O O   . SER D 4 56  ? -0.273  -6.904  22.859  1.00 43.09  ? 55  SER H O   1 
ATOM   5217 C CB  . SER D 4 56  ? 0.322   -8.222  25.210  1.00 30.04  ? 55  SER H CB  1 
ATOM   5218 O OG  . SER D 4 56  ? 0.953   -9.024  26.193  1.00 55.50  ? 55  SER H OG  1 
ATOM   5219 N N   . GLU D 4 57  ? 1.272   -5.298  23.122  1.00 42.99  ? 56  GLU H N   1 
ATOM   5220 C CA  . GLU D 4 57  ? 0.874   -4.615  21.895  1.00 40.88  ? 56  GLU H CA  1 
ATOM   5221 C C   . GLU D 4 57  ? 1.461   -5.362  20.706  1.00 45.44  ? 56  GLU H C   1 
ATOM   5222 O O   . GLU D 4 57  ? 2.683   -5.501  20.597  1.00 43.16  ? 56  GLU H O   1 
ATOM   5223 C CB  . GLU D 4 57  ? 1.341   -3.161  21.890  1.00 35.37  ? 56  GLU H CB  1 
ATOM   5224 C CG  . GLU D 4 57  ? 1.143   -2.470  20.537  1.00 35.28  ? 56  GLU H CG  1 
ATOM   5225 C CD  . GLU D 4 57  ? 1.691   -1.050  20.487  1.00 48.29  ? 56  GLU H CD  1 
ATOM   5226 O OE1 . GLU D 4 57  ? 2.018   -0.488  21.550  1.00 53.59  ? 56  GLU H OE1 1 
ATOM   5227 O OE2 . GLU D 4 57  ? 1.794   -0.494  19.372  1.00 47.29  ? 56  GLU H OE2 1 
ATOM   5228 N N   . THR D 4 58  ? 0.598   -5.847  19.821  1.00 42.30  ? 57  THR H N   1 
ATOM   5229 C CA  . THR D 4 58  ? 1.018   -6.683  18.708  1.00 46.24  ? 57  THR H CA  1 
ATOM   5230 C C   . THR D 4 58  ? 0.731   -5.975  17.392  1.00 36.29  ? 57  THR H C   1 
ATOM   5231 O O   . THR D 4 58  ? -0.355  -5.417  17.205  1.00 44.09  ? 57  THR H O   1 
ATOM   5232 C CB  . THR D 4 58  ? 0.313   -8.043  18.745  1.00 42.24  ? 57  THR H CB  1 
ATOM   5233 O OG1 . THR D 4 58  ? 0.448   -8.611  20.053  1.00 40.05  ? 57  THR H OG1 1 
ATOM   5234 C CG2 . THR D 4 58  ? 0.935   -8.986  17.734  1.00 50.45  ? 57  THR H CG2 1 
ATOM   5235 N N   . ARG D 4 59  ? 1.712   -5.983  16.496  1.00 34.80  ? 58  ARG H N   1 
ATOM   5236 C CA  . ARG D 4 59  ? 1.537   -5.537  15.123  1.00 42.58  ? 58  ARG H CA  1 
ATOM   5237 C C   . ARG D 4 59  ? 1.741   -6.736  14.211  1.00 45.93  ? 58  ARG H C   1 
ATOM   5238 O O   . ARG D 4 59  ? 2.714   -7.479  14.369  1.00 47.35  ? 58  ARG H O   1 
ATOM   5239 C CB  . ARG D 4 59  ? 2.526   -4.427  14.764  1.00 32.91  ? 58  ARG H CB  1 
ATOM   5240 C CG  . ARG D 4 59  ? 2.691   -3.360  15.829  1.00 38.79  ? 58  ARG H CG  1 
ATOM   5241 C CD  . ARG D 4 59  ? 1.640   -2.277  15.705  1.00 54.09  ? 58  ARG H CD  1 
ATOM   5242 N NE  . ARG D 4 59  ? 1.912   -1.152  16.593  1.00 47.38  ? 58  ARG H NE  1 
ATOM   5243 C CZ  . ARG D 4 59  ? 2.665   -0.108  16.273  1.00 42.93  ? 58  ARG H CZ  1 
ATOM   5244 N NH1 . ARG D 4 59  ? 3.259   -0.020  15.094  1.00 36.61  ? 58  ARG H NH1 1 
ATOM   5245 N NH2 . ARG D 4 59  ? 2.824   0.875   17.156  1.00 34.75  ? 58  ARG H NH2 1 
ATOM   5246 N N   . TYR D 4 60  ? 0.826   -6.929  13.270  1.00 47.07  ? 59  TYR H N   1 
ATOM   5247 C CA  . TYR D 4 60  ? 0.882   -8.059  12.356  1.00 50.60  ? 59  TYR H CA  1 
ATOM   5248 C C   . TYR D 4 60  ? 1.134   -7.577  10.934  1.00 58.40  ? 59  TYR H C   1 
ATOM   5249 O O   . TYR D 4 60  ? 0.581   -6.560  10.504  1.00 68.24  ? 59  TYR H O   1 
ATOM   5250 C CB  . TYR D 4 60  ? -0.413  -8.871  12.400  1.00 42.61  ? 59  TYR H CB  1 
ATOM   5251 C CG  . TYR D 4 60  ? -0.548  -9.788  13.594  1.00 45.02  ? 59  TYR H CG  1 
ATOM   5252 C CD1 . TYR D 4 60  ? 0.153   -10.985 13.654  1.00 45.96  ? 59  TYR H CD1 1 
ATOM   5253 C CD2 . TYR D 4 60  ? -1.396  -9.472  14.648  1.00 38.50  ? 59  TYR H CD2 1 
ATOM   5254 C CE1 . TYR D 4 60  ? 0.026   -11.835 14.736  1.00 35.47  ? 59  TYR H CE1 1 
ATOM   5255 C CE2 . TYR D 4 60  ? -1.532  -10.318 15.734  1.00 38.73  ? 59  TYR H CE2 1 
ATOM   5256 C CZ  . TYR D 4 60  ? -0.816  -11.498 15.772  1.00 44.62  ? 59  TYR H CZ  1 
ATOM   5257 O OH  . TYR D 4 60  ? -0.940  -12.347 16.848  1.00 40.20  ? 59  TYR H OH  1 
ATOM   5258 N N   . SER D 4 61  ? 1.979   -8.308  10.214  1.00 51.17  ? 60  SER H N   1 
ATOM   5259 C CA  . SER D 4 61  ? 2.111   -8.095  8.783   1.00 48.50  ? 60  SER H CA  1 
ATOM   5260 C C   . SER D 4 61  ? 0.814   -8.500  8.085   1.00 63.46  ? 60  SER H C   1 
ATOM   5261 O O   . SER D 4 61  ? 0.168   -9.470  8.494   1.00 67.85  ? 60  SER H O   1 
ATOM   5262 C CB  . SER D 4 61  ? 3.281   -8.906  8.225   1.00 48.06  ? 60  SER H CB  1 
ATOM   5263 O OG  . SER D 4 61  ? 3.319   -8.858  6.809   1.00 53.07  ? 60  SER H OG  1 
ATOM   5264 N N   . PRO D 4 62  ? 0.406   -7.783  7.033   1.00 65.12  ? 61  PRO H N   1 
ATOM   5265 C CA  . PRO D 4 62  ? -0.829  -8.168  6.330   1.00 58.84  ? 61  PRO H CA  1 
ATOM   5266 C C   . PRO D 4 62  ? -0.786  -9.580  5.771   1.00 63.91  ? 61  PRO H C   1 
ATOM   5267 O O   . PRO D 4 62  ? -1.837  -10.224 5.658   1.00 66.69  ? 61  PRO H O   1 
ATOM   5268 C CB  . PRO D 4 62  ? -0.943  -7.115  5.217   1.00 60.19  ? 61  PRO H CB  1 
ATOM   5269 C CG  . PRO D 4 62  ? 0.442   -6.575  5.053   1.00 66.20  ? 61  PRO H CG  1 
ATOM   5270 C CD  . PRO D 4 62  ? 1.044   -6.605  6.424   1.00 61.15  ? 61  PRO H CD  1 
ATOM   5271 N N   . SER D 4 63  ? 0.401   -10.084 5.424   1.00 58.70  ? 62  SER H N   1 
ATOM   5272 C CA  . SER D 4 63  ? 0.512   -11.455 4.938   1.00 55.95  ? 62  SER H CA  1 
ATOM   5273 C C   . SER D 4 63  ? 0.217   -12.472 6.033   1.00 58.42  ? 62  SER H C   1 
ATOM   5274 O O   . SER D 4 63  ? -0.348  -13.534 5.756   1.00 58.56  ? 62  SER H O   1 
ATOM   5275 C CB  . SER D 4 63  ? 1.908   -11.697 4.366   1.00 59.39  ? 62  SER H CB  1 
ATOM   5276 O OG  . SER D 4 63  ? 2.232   -10.728 3.384   1.00 62.68  ? 62  SER H OG  1 
ATOM   5277 N N   . PHE D 4 64  ? 0.596   -12.175 7.274   1.00 52.57  ? 63  PHE H N   1 
ATOM   5278 C CA  . PHE D 4 64  ? 0.437   -13.104 8.385   1.00 46.49  ? 63  PHE H CA  1 
ATOM   5279 C C   . PHE D 4 64  ? -0.598  -12.615 9.392   1.00 55.03  ? 63  PHE H C   1 
ATOM   5280 O O   . PHE D 4 64  ? -0.532  -12.963 10.573  1.00 63.12  ? 63  PHE H O   1 
ATOM   5281 C CB  . PHE D 4 64  ? 1.778   -13.339 9.080   1.00 36.56  ? 63  PHE H CB  1 
ATOM   5282 C CG  . PHE D 4 64  ? 2.855   -13.843 8.168   1.00 38.10  ? 63  PHE H CG  1 
ATOM   5283 C CD1 . PHE D 4 64  ? 3.623   -12.962 7.423   1.00 42.42  ? 63  PHE H CD1 1 
ATOM   5284 C CD2 . PHE D 4 64  ? 3.107   -15.200 8.059   1.00 44.54  ? 63  PHE H CD2 1 
ATOM   5285 C CE1 . PHE D 4 64  ? 4.617   -13.425 6.583   1.00 40.41  ? 63  PHE H CE1 1 
ATOM   5286 C CE2 . PHE D 4 64  ? 4.101   -15.671 7.221   1.00 35.87  ? 63  PHE H CE2 1 
ATOM   5287 C CZ  . PHE D 4 64  ? 4.856   -14.782 6.482   1.00 37.03  ? 63  PHE H CZ  1 
ATOM   5288 N N   . GLN D 4 65  ? -1.558  -11.806 8.937   1.00 62.81  ? 64  GLN H N   1 
ATOM   5289 C CA  . GLN D 4 65  ? -2.487  -11.165 9.864   1.00 62.19  ? 64  GLN H CA  1 
ATOM   5290 C C   . GLN D 4 65  ? -3.356  -12.187 10.583  1.00 63.85  ? 64  GLN H C   1 
ATOM   5291 O O   . GLN D 4 65  ? -3.527  -12.123 11.806  1.00 70.45  ? 64  GLN H O   1 
ATOM   5292 C CB  . GLN D 4 65  ? -3.360  -10.152 9.120   1.00 54.78  ? 64  GLN H CB  1 
ATOM   5293 C CG  . GLN D 4 65  ? -3.048  -8.694  9.444   1.00 71.48  ? 64  GLN H CG  1 
ATOM   5294 C CD  . GLN D 4 65  ? -3.470  -8.283  10.849  1.00 63.78  ? 64  GLN H CD  1 
ATOM   5295 O OE1 . GLN D 4 65  ? -4.149  -9.030  11.556  1.00 48.80  ? 64  GLN H OE1 1 
ATOM   5296 N NE2 . GLN D 4 65  ? -3.066  -7.084  11.257  1.00 51.15  ? 64  GLN H NE2 1 
ATOM   5297 N N   . GLY D 4 66  ? -3.913  -13.140 9.845   1.00 43.19  ? 65  GLY H N   1 
ATOM   5298 C CA  . GLY D 4 66  ? -4.847  -14.069 10.446  1.00 43.72  ? 65  GLY H CA  1 
ATOM   5299 C C   . GLY D 4 66  ? -4.360  -15.500 10.502  1.00 54.30  ? 65  GLY H C   1 
ATOM   5300 O O   . GLY D 4 66  ? -5.096  -16.386 10.946  1.00 45.26  ? 65  GLY H O   1 
ATOM   5301 N N   . GLN D 4 67  ? -3.130  -15.746 10.052  1.00 56.81  ? 66  GLN H N   1 
ATOM   5302 C CA  . GLN D 4 67  ? -2.612  -17.108 9.996   1.00 46.78  ? 66  GLN H CA  1 
ATOM   5303 C C   . GLN D 4 67  ? -1.873  -17.520 11.260  1.00 43.37  ? 66  GLN H C   1 
ATOM   5304 O O   . GLN D 4 67  ? -1.790  -18.718 11.556  1.00 38.69  ? 66  GLN H O   1 
ATOM   5305 C CB  . GLN D 4 67  ? -1.683  -17.277 8.789   1.00 48.85  ? 66  GLN H CB  1 
ATOM   5306 C CG  . GLN D 4 67  ? -2.399  -17.590 7.483   1.00 55.99  ? 66  GLN H CG  1 
ATOM   5307 C CD  . GLN D 4 67  ? -3.304  -16.464 7.030   1.00 59.24  ? 66  GLN H CD  1 
ATOM   5308 O OE1 . GLN D 4 67  ? -2.837  -15.444 6.524   1.00 71.87  ? 66  GLN H OE1 1 
ATOM   5309 N NE2 . GLN D 4 67  ? -4.607  -16.640 7.218   1.00 53.69  ? 66  GLN H NE2 1 
ATOM   5310 N N   . VAL D 4 68  ? -1.327  -16.564 12.009  1.00 51.12  ? 67  VAL H N   1 
ATOM   5311 C CA  . VAL D 4 68  ? -0.561  -16.863 13.208  1.00 39.91  ? 67  VAL H CA  1 
ATOM   5312 C C   . VAL D 4 68  ? -1.012  -15.947 14.335  1.00 38.59  ? 67  VAL H C   1 
ATOM   5313 O O   . VAL D 4 68  ? -1.589  -14.880 14.115  1.00 50.10  ? 67  VAL H O   1 
ATOM   5314 C CB  . VAL D 4 68  ? 0.959   -16.716 12.988  1.00 45.86  ? 67  VAL H CB  1 
ATOM   5315 C CG1 . VAL D 4 68  ? 1.449   -17.735 11.982  1.00 35.55  ? 67  VAL H CG1 1 
ATOM   5316 C CG2 . VAL D 4 68  ? 1.291   -15.303 12.534  1.00 49.51  ? 67  VAL H CG2 1 
ATOM   5317 N N   . THR D 4 69  ? -0.732  -16.385 15.557  1.00 36.45  ? 68  THR H N   1 
ATOM   5318 C CA  . THR D 4 69  ? -0.991  -15.608 16.758  1.00 43.41  ? 68  THR H CA  1 
ATOM   5319 C C   . THR D 4 69  ? 0.316   -15.408 17.507  1.00 46.87  ? 68  THR H C   1 
ATOM   5320 O O   . THR D 4 69  ? 1.017   -16.380 17.813  1.00 36.68  ? 68  THR H O   1 
ATOM   5321 C CB  . THR D 4 69  ? -2.012  -16.298 17.662  1.00 43.91  ? 68  THR H CB  1 
ATOM   5322 O OG1 . THR D 4 69  ? -3.308  -16.228 17.056  1.00 58.55  ? 68  THR H OG1 1 
ATOM   5323 C CG2 . THR D 4 69  ? -2.049  -15.628 19.028  1.00 38.78  ? 68  THR H CG2 1 
ATOM   5324 N N   . ILE D 4 70  ? 0.636   -14.155 17.807  1.00 52.33  ? 69  ILE H N   1 
ATOM   5325 C CA  . ILE D 4 70  ? 1.855   -13.801 18.520  1.00 42.04  ? 69  ILE H CA  1 
ATOM   5326 C C   . ILE D 4 70  ? 1.465   -13.302 19.902  1.00 48.28  ? 69  ILE H C   1 
ATOM   5327 O O   . ILE D 4 70  ? 0.701   -12.336 20.029  1.00 60.49  ? 69  ILE H O   1 
ATOM   5328 C CB  . ILE D 4 70  ? 2.668   -12.741 17.767  1.00 33.24  ? 69  ILE H CB  1 
ATOM   5329 C CG1 . ILE D 4 70  ? 2.971   -13.208 16.346  1.00 47.33  ? 69  ILE H CG1 1 
ATOM   5330 C CG2 . ILE D 4 70  ? 3.958   -12.471 18.498  1.00 34.63  ? 69  ILE H CG2 1 
ATOM   5331 C CD1 . ILE D 4 70  ? 3.858   -12.253 15.587  1.00 37.30  ? 69  ILE H CD1 1 
ATOM   5332 N N   . SER D 4 71  ? 1.996   -13.950 20.934  1.00 47.69  ? 70  SER H N   1 
ATOM   5333 C CA  . SER D 4 71  ? 1.707   -13.603 22.316  1.00 44.65  ? 70  SER H CA  1 
ATOM   5334 C C   . SER D 4 71  ? 3.013   -13.456 23.085  1.00 45.38  ? 70  SER H C   1 
ATOM   5335 O O   . SER D 4 71  ? 4.101   -13.722 22.567  1.00 42.96  ? 70  SER H O   1 
ATOM   5336 C CB  . SER D 4 71  ? 0.813   -14.658 22.981  1.00 46.84  ? 70  SER H CB  1 
ATOM   5337 O OG  . SER D 4 71  ? 1.428   -15.935 22.954  1.00 51.24  ? 70  SER H OG  1 
ATOM   5338 N N   . ALA D 4 72  ? 2.899   -13.024 24.338  1.00 50.61  ? 71  ALA H N   1 
ATOM   5339 C CA  . ALA D 4 72  ? 4.066   -12.867 25.192  1.00 50.62  ? 71  ALA H CA  1 
ATOM   5340 C C   . ALA D 4 72  ? 3.653   -13.012 26.648  1.00 45.65  ? 71  ALA H C   1 
ATOM   5341 O O   . ALA D 4 72  ? 2.540   -12.647 27.035  1.00 50.24  ? 71  ALA H O   1 
ATOM   5342 C CB  . ALA D 4 72  ? 4.753   -11.515 24.970  1.00 51.53  ? 71  ALA H CB  1 
ATOM   5343 N N   . ASP D 4 73  ? 4.565   -13.552 27.450  1.00 55.35  ? 72  ASP H N   1 
ATOM   5344 C CA  . ASP D 4 73  ? 4.383   -13.685 28.894  1.00 60.73  ? 72  ASP H CA  1 
ATOM   5345 C C   . ASP D 4 73  ? 5.492   -12.876 29.556  1.00 63.45  ? 72  ASP H C   1 
ATOM   5346 O O   . ASP D 4 73  ? 6.634   -13.337 29.651  1.00 55.30  ? 72  ASP H O   1 
ATOM   5347 C CB  . ASP D 4 73  ? 4.413   -15.148 29.328  1.00 62.24  ? 72  ASP H CB  1 
ATOM   5348 C CG  . ASP D 4 73  ? 3.937   -15.343 30.756  1.00 71.63  ? 72  ASP H CG  1 
ATOM   5349 O OD1 . ASP D 4 73  ? 3.742   -14.333 31.465  1.00 76.57  ? 72  ASP H OD1 1 
ATOM   5350 O OD2 . ASP D 4 73  ? 3.748   -16.507 31.168  1.00 75.91  ? 72  ASP H OD2 1 
ATOM   5351 N N   . LYS D 4 74  ? 5.151   -11.669 30.015  1.00 68.55  ? 73  LYS H N   1 
ATOM   5352 C CA  . LYS D 4 74  ? 6.163   -10.782 30.579  1.00 63.88  ? 73  LYS H CA  1 
ATOM   5353 C C   . LYS D 4 74  ? 6.775   -11.357 31.852  1.00 70.06  ? 73  LYS H C   1 
ATOM   5354 O O   . LYS D 4 74  ? 7.924   -11.040 32.181  1.00 63.47  ? 73  LYS H O   1 
ATOM   5355 C CB  . LYS D 4 74  ? 5.558   -9.399  30.849  1.00 63.24  ? 73  LYS H CB  1 
ATOM   5356 C CG  . LYS D 4 74  ? 5.173   -9.152  32.307  1.00 77.86  ? 73  LYS H CG  1 
ATOM   5357 C CD  . LYS D 4 74  ? 4.672   -7.731  32.551  1.00 64.28  ? 73  LYS H CD  1 
ATOM   5358 C CE  . LYS D 4 74  ? 3.191   -7.585  32.236  1.00 51.24  ? 73  LYS H CE  1 
ATOM   5359 N NZ  . LYS D 4 74  ? 2.750   -6.167  32.369  1.00 64.22  ? 73  LYS H NZ  1 
ATOM   5360 N N   . SER D 4 75  ? 6.035   -12.209 32.569  1.00 69.06  ? 74  SER H N   1 
ATOM   5361 C CA  . SER D 4 75  ? 6.523   -12.734 33.840  1.00 59.78  ? 74  SER H CA  1 
ATOM   5362 C C   . SER D 4 75  ? 7.761   -13.602 33.658  1.00 63.29  ? 74  SER H C   1 
ATOM   5363 O O   . SER D 4 75  ? 8.626   -13.642 34.540  1.00 63.93  ? 74  SER H O   1 
ATOM   5364 C CB  . SER D 4 75  ? 5.416   -13.526 34.537  1.00 57.41  ? 74  SER H CB  1 
ATOM   5365 O OG  . SER D 4 75  ? 4.975   -14.606 33.731  1.00 71.63  ? 74  SER H OG  1 
ATOM   5366 N N   . ILE D 4 76  ? 7.863   -14.300 32.529  1.00 62.74  ? 75  ILE H N   1 
ATOM   5367 C CA  . ILE D 4 76  ? 8.974   -15.197 32.250  1.00 60.88  ? 75  ILE H CA  1 
ATOM   5368 C C   . ILE D 4 76  ? 9.815   -14.719 31.072  1.00 54.62  ? 75  ILE H C   1 
ATOM   5369 O O   . ILE D 4 76  ? 10.719  -15.432 30.631  1.00 44.31  ? 75  ILE H O   1 
ATOM   5370 C CB  . ILE D 4 76  ? 8.473   -16.636 32.024  1.00 57.33  ? 75  ILE H CB  1 
ATOM   5371 C CG1 . ILE D 4 76  ? 7.445   -16.665 30.888  1.00 69.56  ? 75  ILE H CG1 1 
ATOM   5372 C CG2 . ILE D 4 76  ? 7.868   -17.179 33.304  1.00 56.61  ? 75  ILE H CG2 1 
ATOM   5373 C CD1 . ILE D 4 76  ? 6.625   -17.945 30.818  1.00 61.28  ? 75  ILE H CD1 1 
ATOM   5374 N N   . ASN D 4 77  ? 9.539   -13.519 30.559  1.00 47.18  ? 76  ASN H N   1 
ATOM   5375 C CA  . ASN D 4 77  ? 10.306  -12.931 29.460  1.00 54.98  ? 76  ASN H CA  1 
ATOM   5376 C C   . ASN D 4 77  ? 10.336  -13.858 28.247  1.00 49.82  ? 76  ASN H C   1 
ATOM   5377 O O   . ASN D 4 77  ? 11.389  -14.126 27.665  1.00 47.84  ? 76  ASN H O   1 
ATOM   5378 C CB  . ASN D 4 77  ? 11.725  -12.578 29.912  1.00 48.39  ? 76  ASN H CB  1 
ATOM   5379 C CG  . ASN D 4 77  ? 11.741  -11.614 31.078  1.00 53.15  ? 76  ASN H CG  1 
ATOM   5380 O OD1 . ASN D 4 77  ? 10.764  -10.906 31.326  1.00 61.81  ? 76  ASN H OD1 1 
ATOM   5381 N ND2 . ASN D 4 77  ? 12.854  -11.576 31.799  1.00 54.80  ? 76  ASN H ND2 1 
ATOM   5382 N N   . THR D 4 78  ? 9.160   -14.358 27.871  1.00 47.44  ? 77  THR H N   1 
ATOM   5383 C CA  . THR D 4 78  ? 9.029   -15.310 26.777  1.00 46.99  ? 77  THR H CA  1 
ATOM   5384 C C   . THR D 4 78  ? 7.956   -14.842 25.806  1.00 45.14  ? 77  THR H C   1 
ATOM   5385 O O   . THR D 4 78  ? 6.869   -14.429 26.226  1.00 48.56  ? 77  THR H O   1 
ATOM   5386 C CB  . THR D 4 78  ? 8.684   -16.710 27.300  1.00 54.42  ? 77  THR H CB  1 
ATOM   5387 O OG1 . THR D 4 78  ? 9.724   -17.166 28.175  1.00 66.15  ? 77  THR H OG1 1 
ATOM   5388 C CG2 . THR D 4 78  ? 8.542   -17.686 26.149  1.00 54.06  ? 77  THR H CG2 1 
ATOM   5389 N N   . ALA D 4 79  ? 8.263   -14.911 24.512  1.00 46.81  ? 78  ALA H N   1 
ATOM   5390 C CA  . ALA D 4 79  ? 7.320   -14.610 23.445  1.00 51.63  ? 78  ALA H CA  1 
ATOM   5391 C C   . ALA D 4 79  ? 6.991   -15.888 22.685  1.00 47.70  ? 78  ALA H C   1 
ATOM   5392 O O   . ALA D 4 79  ? 7.859   -16.744 22.485  1.00 57.96  ? 78  ALA H O   1 
ATOM   5393 C CB  . ALA D 4 79  ? 7.885   -13.562 22.483  1.00 38.75  ? 78  ALA H CB  1 
ATOM   5394 N N   . TYR D 4 80  ? 5.741   -16.011 22.251  1.00 44.41  ? 79  TYR H N   1 
ATOM   5395 C CA  . TYR D 4 80  ? 5.257   -17.233 21.633  1.00 38.39  ? 79  TYR H CA  1 
ATOM   5396 C C   . TYR D 4 80  ? 4.729   -16.958 20.230  1.00 43.71  ? 79  TYR H C   1 
ATOM   5397 O O   . TYR D 4 80  ? 4.240   -15.865 19.930  1.00 51.33  ? 79  TYR H O   1 
ATOM   5398 C CB  . TYR D 4 80  ? 4.156   -17.878 22.485  1.00 45.02  ? 79  TYR H CB  1 
ATOM   5399 C CG  . TYR D 4 80  ? 4.589   -18.224 23.894  1.00 50.67  ? 79  TYR H CG  1 
ATOM   5400 C CD1 . TYR D 4 80  ? 5.195   -19.442 24.176  1.00 55.97  ? 79  TYR H CD1 1 
ATOM   5401 C CD2 . TYR D 4 80  ? 4.389   -17.335 24.944  1.00 52.01  ? 79  TYR H CD2 1 
ATOM   5402 C CE1 . TYR D 4 80  ? 5.591   -19.765 25.466  1.00 60.36  ? 79  TYR H CE1 1 
ATOM   5403 C CE2 . TYR D 4 80  ? 4.782   -17.649 26.236  1.00 51.31  ? 79  TYR H CE2 1 
ATOM   5404 C CZ  . TYR D 4 80  ? 5.380   -18.866 26.491  1.00 58.12  ? 79  TYR H CZ  1 
ATOM   5405 O OH  . TYR D 4 80  ? 5.772   -19.180 27.774  1.00 50.95  ? 79  TYR H OH  1 
ATOM   5406 N N   . LEU D 4 81  ? 4.842   -17.969 19.373  1.00 47.80  ? 80  LEU H N   1 
ATOM   5407 C CA  . LEU D 4 81  ? 4.272   -17.950 18.033  1.00 44.09  ? 80  LEU H CA  1 
ATOM   5408 C C   . LEU D 4 81  ? 3.403   -19.188 17.869  1.00 41.77  ? 80  LEU H C   1 
ATOM   5409 O O   . LEU D 4 81  ? 3.877   -20.309 18.075  1.00 49.11  ? 80  LEU H O   1 
ATOM   5410 C CB  . LEU D 4 81  ? 5.374   -17.916 16.976  1.00 45.35  ? 80  LEU H CB  1 
ATOM   5411 C CG  . LEU D 4 81  ? 4.948   -17.950 15.514  1.00 46.13  ? 80  LEU H CG  1 
ATOM   5412 C CD1 . LEU D 4 81  ? 4.018   -16.788 15.190  1.00 38.30  ? 80  LEU H CD1 1 
ATOM   5413 C CD2 . LEU D 4 81  ? 6.198   -17.906 14.668  1.00 33.90  ? 80  LEU H CD2 1 
ATOM   5414 N N   . GLN D 4 82  ? 2.140   -18.991 17.499  1.00 42.07  ? 81  GLN H N   1 
ATOM   5415 C CA  . GLN D 4 82  ? 1.154   -20.061 17.529  1.00 42.91  ? 81  GLN H CA  1 
ATOM   5416 C C   . GLN D 4 82  ? 0.575   -20.333 16.147  1.00 42.09  ? 81  GLN H C   1 
ATOM   5417 O O   . GLN D 4 82  ? 0.445   -19.429 15.316  1.00 48.08  ? 81  GLN H O   1 
ATOM   5418 C CB  . GLN D 4 82  ? 0.008   -19.733 18.493  1.00 42.11  ? 81  GLN H CB  1 
ATOM   5419 C CG  . GLN D 4 82  ? -0.006  -20.584 19.750  1.00 57.75  ? 81  GLN H CG  1 
ATOM   5420 C CD  . GLN D 4 82  ? -1.261  -20.382 20.573  1.00 72.16  ? 81  GLN H CD  1 
ATOM   5421 O OE1 . GLN D 4 82  ? -2.268  -19.874 20.077  1.00 79.68  ? 81  GLN H OE1 1 
ATOM   5422 N NE2 . GLN D 4 82  ? -1.209  -20.781 21.839  1.00 72.06  ? 81  GLN H NE2 1 
ATOM   5423 N N   . TRP D 4 83  ? 0.231   -21.600 15.916  1.00 43.13  ? 82  TRP H N   1 
ATOM   5424 C CA  . TRP D 4 83  ? -0.536  -22.023 14.752  1.00 43.20  ? 82  TRP H CA  1 
ATOM   5425 C C   . TRP D 4 83  ? -1.723  -22.852 15.216  1.00 50.07  ? 82  TRP H C   1 
ATOM   5426 O O   . TRP D 4 83  ? -1.570  -23.745 16.054  1.00 45.78  ? 82  TRP H O   1 
ATOM   5427 C CB  . TRP D 4 83  ? 0.306   -22.849 13.780  1.00 44.64  ? 82  TRP H CB  1 
ATOM   5428 C CG  . TRP D 4 83  ? 1.266   -22.055 12.975  1.00 44.90  ? 82  TRP H CG  1 
ATOM   5429 C CD1 . TRP D 4 83  ? 1.024   -21.441 11.780  1.00 42.28  ? 82  TRP H CD1 1 
ATOM   5430 C CD2 . TRP D 4 83  ? 2.636   -21.796 13.291  1.00 48.61  ? 82  TRP H CD2 1 
ATOM   5431 N NE1 . TRP D 4 83  ? 2.161   -20.811 11.335  1.00 44.28  ? 82  TRP H NE1 1 
ATOM   5432 C CE2 . TRP D 4 83  ? 3.164   -21.012 12.247  1.00 49.17  ? 82  TRP H CE2 1 
ATOM   5433 C CE3 . TRP D 4 83  ? 3.467   -22.147 14.359  1.00 45.14  ? 82  TRP H CE3 1 
ATOM   5434 C CZ2 . TRP D 4 83  ? 4.485   -20.574 12.240  1.00 38.12  ? 82  TRP H CZ2 1 
ATOM   5435 C CZ3 . TRP D 4 83  ? 4.777   -21.712 14.349  1.00 48.38  ? 82  TRP H CZ3 1 
ATOM   5436 C CH2 . TRP D 4 83  ? 5.274   -20.936 13.295  1.00 45.15  ? 82  TRP H CH2 1 
ATOM   5437 N N   . SER D 4 84  A -2.899  -22.565 14.661  1.00 59.30  ? 82  SER H N   1 
ATOM   5438 C CA  . SER D 4 84  A -4.071  -23.368 14.982  1.00 46.81  ? 82  SER H CA  1 
ATOM   5439 C C   . SER D 4 84  A -4.079  -24.665 14.180  1.00 61.54  ? 82  SER H C   1 
ATOM   5440 O O   . SER D 4 84  A -4.236  -25.752 14.747  1.00 65.78  ? 82  SER H O   1 
ATOM   5441 C CB  . SER D 4 84  A -5.343  -22.557 14.732  1.00 52.88  ? 82  SER H CB  1 
ATOM   5442 O OG  . SER D 4 84  A -5.352  -22.014 13.423  1.00 74.36  ? 82  SER H OG  1 
ATOM   5443 N N   . SER D 4 85  B -3.891  -24.573 12.863  1.00 58.27  ? 82  SER H N   1 
ATOM   5444 C CA  . SER D 4 85  B -3.811  -25.739 11.987  1.00 54.91  ? 82  SER H CA  1 
ATOM   5445 C C   . SER D 4 85  B -2.625  -25.558 11.049  1.00 60.57  ? 82  SER H C   1 
ATOM   5446 O O   . SER D 4 85  B -2.627  -24.652 10.208  1.00 58.95  ? 82  SER H O   1 
ATOM   5447 C CB  . SER D 4 85  B -5.101  -25.925 11.191  1.00 49.00  ? 82  SER H CB  1 
ATOM   5448 O OG  . SER D 4 85  B -5.303  -24.833 10.312  1.00 75.51  ? 82  SER H OG  1 
ATOM   5449 N N   . LEU D 4 86  C -1.626  -26.425 11.181  1.00 49.50  ? 82  LEU H N   1 
ATOM   5450 C CA  . LEU D 4 86  C -0.422  -26.309 10.374  1.00 51.24  ? 82  LEU H CA  1 
ATOM   5451 C C   . LEU D 4 86  C -0.682  -26.740 8.933   1.00 49.55  ? 82  LEU H C   1 
ATOM   5452 O O   . LEU D 4 86  C -1.615  -27.488 8.630   1.00 50.43  ? 82  LEU H O   1 
ATOM   5453 C CB  . LEU D 4 86  C 0.709   -27.145 10.973  1.00 40.77  ? 82  LEU H CB  1 
ATOM   5454 C CG  . LEU D 4 86  C 1.453   -26.520 12.152  1.00 43.57  ? 82  LEU H CG  1 
ATOM   5455 C CD1 . LEU D 4 86  C 2.421   -27.517 12.753  1.00 48.41  ? 82  LEU H CD1 1 
ATOM   5456 C CD2 . LEU D 4 86  C 2.187   -25.261 11.716  1.00 38.27  ? 82  LEU H CD2 1 
ATOM   5457 N N   . LYS D 4 87  ? 0.169   -26.248 8.039   1.00 49.54  ? 83  LYS H N   1 
ATOM   5458 C CA  . LYS D 4 87  ? 0.142   -26.613 6.635   1.00 43.21  ? 83  LYS H CA  1 
ATOM   5459 C C   . LYS D 4 87  ? 1.563   -26.896 6.176   1.00 53.53  ? 83  LYS H C   1 
ATOM   5460 O O   . LYS D 4 87  ? 2.538   -26.446 6.784   1.00 53.05  ? 83  LYS H O   1 
ATOM   5461 C CB  . LYS D 4 87  ? -0.493  -25.512 5.777   1.00 42.58  ? 83  LYS H CB  1 
ATOM   5462 C CG  . LYS D 4 87  ? -2.007  -25.493 5.853   1.00 58.45  ? 83  LYS H CG  1 
ATOM   5463 C CD  . LYS D 4 87  ? -2.586  -24.294 5.125   1.00 64.82  ? 83  LYS H CD  1 
ATOM   5464 C CE  . LYS D 4 87  ? -2.437  -23.027 5.949   1.00 71.85  ? 83  LYS H CE  1 
ATOM   5465 N NZ  . LYS D 4 87  ? -3.196  -23.111 7.229   1.00 69.68  ? 83  LYS H NZ  1 
ATOM   5466 N N   . ALA D 4 88  ? 1.675   -27.672 5.097   1.00 55.82  ? 84  ALA H N   1 
ATOM   5467 C CA  . ALA D 4 88  ? 2.996   -27.972 4.560   1.00 58.20  ? 84  ALA H CA  1 
ATOM   5468 C C   . ALA D 4 88  ? 3.709   -26.706 4.113   1.00 56.69  ? 84  ALA H C   1 
ATOM   5469 O O   . ALA D 4 88  ? 4.944   -26.665 4.084   1.00 64.26  ? 84  ALA H O   1 
ATOM   5470 C CB  . ALA D 4 88  ? 2.892   -28.968 3.406   1.00 51.47  ? 84  ALA H CB  1 
ATOM   5471 N N   . SER D 4 89  ? 2.952   -25.662 3.770   1.00 47.68  ? 85  SER H N   1 
ATOM   5472 C CA  . SER D 4 89  ? 3.554   -24.398 3.360   1.00 45.85  ? 85  SER H CA  1 
ATOM   5473 C C   . SER D 4 89  ? 4.260   -23.689 4.509   1.00 48.87  ? 85  SER H C   1 
ATOM   5474 O O   . SER D 4 89  ? 5.053   -22.773 4.265   1.00 50.53  ? 85  SER H O   1 
ATOM   5475 C CB  . SER D 4 89  ? 2.484   -23.482 2.764   1.00 61.34  ? 85  SER H CB  1 
ATOM   5476 O OG  . SER D 4 89  ? 1.432   -23.263 3.692   1.00 66.64  ? 85  SER H OG  1 
ATOM   5477 N N   . ASP D 4 90  ? 3.992   -24.092 5.749   1.00 51.41  ? 86  ASP H N   1 
ATOM   5478 C CA  . ASP D 4 90  ? 4.598   -23.491 6.928   1.00 45.01  ? 86  ASP H CA  1 
ATOM   5479 C C   . ASP D 4 90  ? 5.942   -24.112 7.281   1.00 45.42  ? 86  ASP H C   1 
ATOM   5480 O O   . ASP D 4 90  ? 6.550   -23.714 8.280   1.00 44.84  ? 86  ASP H O   1 
ATOM   5481 C CB  . ASP D 4 90  ? 3.646   -23.605 8.126   1.00 54.28  ? 86  ASP H CB  1 
ATOM   5482 C CG  . ASP D 4 90  ? 2.324   -22.892 7.894   1.00 60.02  ? 86  ASP H CG  1 
ATOM   5483 O OD1 . ASP D 4 90  ? 2.319   -21.853 7.201   1.00 67.07  ? 86  ASP H OD1 1 
ATOM   5484 O OD2 . ASP D 4 90  ? 1.289   -23.371 8.405   1.00 55.62  ? 86  ASP H OD2 1 
ATOM   5485 N N   . THR D 4 91  ? 6.415   -25.074 6.496   1.00 46.53  ? 87  THR H N   1 
ATOM   5486 C CA  . THR D 4 91  ? 7.694   -25.722 6.761   1.00 39.32  ? 87  THR H CA  1 
ATOM   5487 C C   . THR D 4 91  ? 8.811   -24.725 6.493   1.00 39.41  ? 87  THR H C   1 
ATOM   5488 O O   . THR D 4 91  ? 9.161   -24.455 5.343   1.00 48.89  ? 87  THR H O   1 
ATOM   5489 C CB  . THR D 4 91  ? 7.848   -26.969 5.900   1.00 43.37  ? 87  THR H CB  1 
ATOM   5490 O OG1 . THR D 4 91  ? 6.786   -27.885 6.194   1.00 59.81  ? 87  THR H OG1 1 
ATOM   5491 C CG2 . THR D 4 91  ? 9.183   -27.642 6.179   1.00 36.03  ? 87  THR H CG2 1 
ATOM   5492 N N   . ALA D 4 92  ? 9.374   -24.174 7.563   1.00 42.73  ? 88  ALA H N   1 
ATOM   5493 C CA  . ALA D 4 92  ? 10.449  -23.198 7.460   1.00 44.97  ? 88  ALA H CA  1 
ATOM   5494 C C   . ALA D 4 92  ? 11.123  -23.081 8.817   1.00 40.78  ? 88  ALA H C   1 
ATOM   5495 O O   . ALA D 4 92  ? 10.684  -23.676 9.803   1.00 57.13  ? 88  ALA H O   1 
ATOM   5496 C CB  . ALA D 4 92  ? 9.927   -21.834 6.993   1.00 49.88  ? 88  ALA H CB  1 
ATOM   5497 N N   . ILE D 4 93  ? 12.198  -22.299 8.856   1.00 42.08  ? 89  ILE H N   1 
ATOM   5498 C CA  . ILE D 4 93  ? 12.873  -21.962 10.104  1.00 44.67  ? 89  ILE H CA  1 
ATOM   5499 C C   . ILE D 4 93  ? 12.438  -20.565 10.524  1.00 38.93  ? 89  ILE H C   1 
ATOM   5500 O O   . ILE D 4 93  ? 12.449  -19.628 9.715   1.00 38.22  ? 89  ILE H O   1 
ATOM   5501 C CB  . ILE D 4 93  ? 14.404  -22.065 9.971   1.00 34.88  ? 89  ILE H CB  1 
ATOM   5502 C CG1 . ILE D 4 93  ? 15.084  -21.439 11.190  1.00 33.67  ? 89  ILE H CG1 1 
ATOM   5503 C CG2 . ILE D 4 93  ? 14.901  -21.430 8.678   1.00 36.58  ? 89  ILE H CG2 1 
ATOM   5504 C CD1 . ILE D 4 93  ? 16.508  -21.909 11.403  1.00 47.37  ? 89  ILE H CD1 1 
ATOM   5505 N N   . TYR D 4 94  ? 12.026  -20.434 11.781  1.00 38.70  ? 90  TYR H N   1 
ATOM   5506 C CA  . TYR D 4 94  ? 11.492  -19.192 12.322  1.00 36.93  ? 90  TYR H CA  1 
ATOM   5507 C C   . TYR D 4 94  ? 12.478  -18.630 13.336  1.00 37.46  ? 90  TYR H C   1 
ATOM   5508 O O   . TYR D 4 94  ? 12.834  -19.311 14.303  1.00 42.04  ? 90  TYR H O   1 
ATOM   5509 C CB  . TYR D 4 94  ? 10.126  -19.427 12.971  1.00 42.97  ? 90  TYR H CB  1 
ATOM   5510 C CG  . TYR D 4 94  ? 9.072   -19.912 12.003  1.00 34.46  ? 90  TYR H CG  1 
ATOM   5511 C CD1 . TYR D 4 94  ? 8.965   -21.257 11.676  1.00 36.39  ? 90  TYR H CD1 1 
ATOM   5512 C CD2 . TYR D 4 94  ? 8.189   -19.021 11.409  1.00 42.21  ? 90  TYR H CD2 1 
ATOM   5513 C CE1 . TYR D 4 94  ? 8.007   -21.703 10.783  1.00 45.47  ? 90  TYR H CE1 1 
ATOM   5514 C CE2 . TYR D 4 94  ? 7.227   -19.457 10.518  1.00 46.79  ? 90  TYR H CE2 1 
ATOM   5515 C CZ  . TYR D 4 94  ? 7.140   -20.797 10.207  1.00 43.45  ? 90  TYR H CZ  1 
ATOM   5516 O OH  . TYR D 4 94  ? 6.179   -21.225 9.319   1.00 45.93  ? 90  TYR H OH  1 
ATOM   5517 N N   . TYR D 4 95  ? 12.911  -17.396 13.115  1.00 33.86  ? 91  TYR H N   1 
ATOM   5518 C CA  . TYR D 4 95  ? 13.735  -16.678 14.074  1.00 39.48  ? 91  TYR H CA  1 
ATOM   5519 C C   . TYR D 4 95  ? 12.877  -15.686 14.850  1.00 37.26  ? 91  TYR H C   1 
ATOM   5520 O O   . TYR D 4 95  ? 11.875  -15.175 14.343  1.00 37.49  ? 91  TYR H O   1 
ATOM   5521 C CB  . TYR D 4 95  ? 14.874  -15.927 13.375  1.00 40.83  ? 91  TYR H CB  1 
ATOM   5522 C CG  . TYR D 4 95  ? 15.804  -16.786 12.544  1.00 36.87  ? 91  TYR H CG  1 
ATOM   5523 C CD1 . TYR D 4 95  ? 16.921  -17.389 13.110  1.00 34.44  ? 91  TYR H CD1 1 
ATOM   5524 C CD2 . TYR D 4 95  ? 15.578  -16.974 11.187  1.00 40.66  ? 91  TYR H CD2 1 
ATOM   5525 C CE1 . TYR D 4 95  ? 17.777  -18.168 12.349  1.00 32.81  ? 91  TYR H CE1 1 
ATOM   5526 C CE2 . TYR D 4 95  ? 16.430  -17.749 10.418  1.00 39.57  ? 91  TYR H CE2 1 
ATOM   5527 C CZ  . TYR D 4 95  ? 17.527  -18.342 11.003  1.00 39.78  ? 91  TYR H CZ  1 
ATOM   5528 O OH  . TYR D 4 95  ? 18.369  -19.112 10.233  1.00 51.30  ? 91  TYR H OH  1 
ATOM   5529 N N   . CYS D 4 96  ? 13.269  -15.420 16.091  1.00 35.23  ? 92  CYS H N   1 
ATOM   5530 C CA  . CYS D 4 96  ? 12.728  -14.296 16.843  1.00 41.86  ? 92  CYS H CA  1 
ATOM   5531 C C   . CYS D 4 96  ? 13.833  -13.272 17.054  1.00 44.87  ? 92  CYS H C   1 
ATOM   5532 O O   . CYS D 4 96  ? 14.919  -13.611 17.536  1.00 52.53  ? 92  CYS H O   1 
ATOM   5533 C CB  . CYS D 4 96  ? 12.135  -14.734 18.185  1.00 38.94  ? 92  CYS H CB  1 
ATOM   5534 S SG  . CYS D 4 96  ? 13.299  -15.475 19.344  1.00 64.25  ? 92  CYS H SG  1 
ATOM   5535 N N   . ALA D 4 97  ? 13.556  -12.028 16.678  1.00 43.65  ? 93  ALA H N   1 
ATOM   5536 C CA  . ALA D 4 97  ? 14.523  -10.945 16.736  1.00 38.93  ? 93  ALA H CA  1 
ATOM   5537 C C   . ALA D 4 97  ? 14.067  -9.889  17.731  1.00 34.19  ? 93  ALA H C   1 
ATOM   5538 O O   . ALA D 4 97  ? 12.870  -9.633  17.889  1.00 39.27  ? 93  ALA H O   1 
ATOM   5539 C CB  . ALA D 4 97  ? 14.719  -10.310 15.355  1.00 43.65  ? 93  ALA H CB  1 
ATOM   5540 N N   . GLY D 4 98  ? 15.039  -9.281  18.398  1.00 40.45  ? 94  GLY H N   1 
ATOM   5541 C CA  . GLY D 4 98  ? 14.785  -8.293  19.435  1.00 41.71  ? 94  GLY H CA  1 
ATOM   5542 C C   . GLY D 4 98  ? 15.267  -6.919  19.006  1.00 47.56  ? 94  GLY H C   1 
ATOM   5543 O O   . GLY D 4 98  ? 16.318  -6.787  18.373  1.00 38.87  ? 94  GLY H O   1 
ATOM   5544 N N   . GLY D 4 99  ? 14.477  -5.904  19.341  1.00 46.87  ? 95  GLY H N   1 
ATOM   5545 C CA  . GLY D 4 99  ? 14.848  -4.526  19.096  1.00 31.43  ? 95  GLY H CA  1 
ATOM   5546 C C   . GLY D 4 99  ? 14.410  -3.642  20.244  1.00 38.28  ? 95  GLY H C   1 
ATOM   5547 O O   . GLY D 4 99  ? 13.297  -3.790  20.759  1.00 35.88  ? 95  GLY H O   1 
ATOM   5548 N N   . SER D 4 100 ? 15.264  -2.713  20.647  1.00 43.82  ? 96  SER H N   1 
ATOM   5549 C CA  . SER D 4 100 ? 14.978  -1.909  21.833  1.00 42.14  ? 96  SER H CA  1 
ATOM   5550 C C   . SER D 4 100 ? 13.872  -0.886  21.618  1.00 46.85  ? 96  SER H C   1 
ATOM   5551 O O   . SER D 4 100 ? 13.626  -0.075  22.521  1.00 61.70  ? 96  SER H O   1 
ATOM   5552 C CB  . SER D 4 100 ? 16.255  -1.214  22.297  1.00 44.66  ? 96  SER H CB  1 
ATOM   5553 O OG  . SER D 4 100 ? 16.779  -0.409  21.260  1.00 59.85  ? 96  SER H OG  1 
ATOM   5554 N N   . GLY D 4 101 ? 13.200  -0.884  20.474  1.00 41.53  ? 97  GLY H N   1 
ATOM   5555 C CA  . GLY D 4 101 ? 12.039  -0.034  20.288  1.00 44.07  ? 97  GLY H CA  1 
ATOM   5556 C C   . GLY D 4 101 ? 11.349  -0.378  18.990  1.00 45.44  ? 97  GLY H C   1 
ATOM   5557 O O   . GLY D 4 101 ? 11.871  -1.128  18.160  1.00 43.59  ? 97  GLY H O   1 
ATOM   5558 N N   . ILE D 4 102 ? 10.145  0.169   18.831  1.00 37.44  ? 98  ILE H N   1 
ATOM   5559 C CA  . ILE D 4 102 ? 9.467   0.061   17.550  1.00 34.74  ? 98  ILE H CA  1 
ATOM   5560 C C   . ILE D 4 102 ? 10.173  0.970   16.549  1.00 35.85  ? 98  ILE H C   1 
ATOM   5561 O O   . ILE D 4 102 ? 10.756  2.002   16.915  1.00 38.40  ? 98  ILE H O   1 
ATOM   5562 C CB  . ILE D 4 102 ? 7.974   0.410   17.696  1.00 39.32  ? 98  ILE H CB  1 
ATOM   5563 C CG1 . ILE D 4 102 ? 7.191   0.056   16.428  1.00 40.58  ? 98  ILE H CG1 1 
ATOM   5564 C CG2 . ILE D 4 102 ? 7.803   1.871   18.024  1.00 51.74  ? 98  ILE H CG2 1 
ATOM   5565 C CD1 . ILE D 4 102 ? 7.044   -1.426  16.186  1.00 35.65  ? 98  ILE H CD1 1 
ATOM   5566 N N   . PHE D 4 103 ? 10.153  0.568   15.277  1.00 38.93  ? 99  PHE H N   1 
ATOM   5567 C CA  . PHE D 4 103 ? 10.858  1.288   14.213  1.00 42.44  ? 99  PHE H CA  1 
ATOM   5568 C C   . PHE D 4 103 ? 12.350  1.400   14.523  1.00 45.39  ? 99  PHE H C   1 
ATOM   5569 O O   . PHE D 4 103 ? 12.965  2.454   14.358  1.00 49.65  ? 99  PHE H O   1 
ATOM   5570 C CB  . PHE D 4 103 ? 10.238  2.667   13.977  1.00 34.55  ? 99  PHE H CB  1 
ATOM   5571 C CG  . PHE D 4 103 ? 8.740   2.642   13.855  1.00 41.21  ? 99  PHE H CG  1 
ATOM   5572 C CD1 . PHE D 4 103 ? 8.116   1.771   12.975  1.00 41.41  ? 99  PHE H CD1 1 
ATOM   5573 C CD2 . PHE D 4 103 ? 7.954   3.474   14.637  1.00 37.33  ? 99  PHE H CD2 1 
ATOM   5574 C CE1 . PHE D 4 103 ? 6.736   1.742   12.865  1.00 37.68  ? 99  PHE H CE1 1 
ATOM   5575 C CE2 . PHE D 4 103 ? 6.572   3.447   14.532  1.00 28.20  ? 99  PHE H CE2 1 
ATOM   5576 C CZ  . PHE D 4 103 ? 5.964   2.581   13.646  1.00 33.31  ? 99  PHE H CZ  1 
ATOM   5577 N N   . THR D 4 104 ? 12.932  0.308   15.001  1.00 47.43  ? 100 THR H N   1 
ATOM   5578 C CA  . THR D 4 104 ? 14.354  0.236   15.284  1.00 39.14  ? 100 THR H CA  1 
ATOM   5579 C C   . THR D 4 104 ? 14.913  -1.047  14.688  1.00 36.43  ? 100 THR H C   1 
ATOM   5580 O O   . THR D 4 104 ? 14.174  -2.018  14.491  1.00 34.68  ? 100 THR H O   1 
ATOM   5581 C CB  . THR D 4 104 ? 14.630  0.281   16.797  1.00 35.62  ? 100 THR H CB  1 
ATOM   5582 O OG1 . THR D 4 104 ? 14.024  -0.848  17.437  1.00 46.86  ? 100 THR H OG1 1 
ATOM   5583 C CG2 . THR D 4 104 ? 14.074  1.559   17.405  1.00 36.97  ? 100 THR H CG2 1 
ATOM   5584 N N   . PRO D 4 105 A 16.203  -1.074  14.365  1.00 43.68  ? 100 PRO H N   1 
ATOM   5585 C CA  . PRO D 4 105 A 16.792  -2.298  13.817  1.00 38.06  ? 100 PRO H CA  1 
ATOM   5586 C C   . PRO D 4 105 A 16.808  -3.416  14.846  1.00 47.20  ? 100 PRO H C   1 
ATOM   5587 O O   . PRO D 4 105 A 16.855  -3.184  16.057  1.00 47.18  ? 100 PRO H O   1 
ATOM   5588 C CB  . PRO D 4 105 A 18.214  -1.869  13.440  1.00 39.73  ? 100 PRO H CB  1 
ATOM   5589 C CG  . PRO D 4 105 A 18.500  -0.715  14.342  1.00 48.62  ? 100 PRO H CG  1 
ATOM   5590 C CD  . PRO D 4 105 A 17.197  0.007   14.488  1.00 49.44  ? 100 PRO H CD  1 
ATOM   5591 N N   . MET D 4 106 B 16.761  -4.646  14.341  1.00 56.85  ? 100 MET H N   1 
ATOM   5592 C CA  . MET D 4 106 B 16.808  -5.844  15.173  1.00 48.83  ? 100 MET H CA  1 
ATOM   5593 C C   . MET D 4 106 B 18.268  -6.206  15.425  1.00 48.93  ? 100 MET H C   1 
ATOM   5594 O O   . MET D 4 106 B 18.959  -6.687  14.520  1.00 48.17  ? 100 MET H O   1 
ATOM   5595 C CB  . MET D 4 106 B 16.068  -6.990  14.488  1.00 49.24  ? 100 MET H CB  1 
ATOM   5596 C CG  . MET D 4 106 B 14.609  -6.693  14.166  1.00 47.38  ? 100 MET H CG  1 
ATOM   5597 S SD  . MET D 4 106 B 14.033  -7.606  12.714  1.00 55.99  ? 100 MET H SD  1 
ATOM   5598 C CE  . MET D 4 106 B 12.265  -7.532  12.945  1.00 57.49  ? 100 MET H CE  1 
ATOM   5599 N N   . ASP D 4 107 ? 18.742  -5.977  16.652  1.00 36.34  ? 101 ASP H N   1 
ATOM   5600 C CA  . ASP D 4 107 ? 20.138  -6.234  16.983  1.00 48.61  ? 101 ASP H CA  1 
ATOM   5601 C C   . ASP D 4 107 ? 20.377  -7.590  17.637  1.00 47.69  ? 101 ASP H C   1 
ATOM   5602 O O   . ASP D 4 107 ? 21.492  -8.115  17.541  1.00 60.78  ? 101 ASP H O   1 
ATOM   5603 C CB  . ASP D 4 107 ? 20.683  -5.131  17.902  1.00 50.90  ? 101 ASP H CB  1 
ATOM   5604 C CG  . ASP D 4 107 ? 19.671  -4.677  18.933  1.00 56.35  ? 101 ASP H CG  1 
ATOM   5605 O OD1 . ASP D 4 107 ? 19.259  -3.496  18.891  1.00 64.02  ? 101 ASP H OD1 1 
ATOM   5606 O OD2 . ASP D 4 107 ? 19.275  -5.509  19.775  1.00 65.16  ? 101 ASP H OD2 1 
ATOM   5607 N N   . VAL D 4 108 ? 19.371  -8.172  18.285  1.00 45.59  ? 102 VAL H N   1 
ATOM   5608 C CA  . VAL D 4 108 ? 19.499  -9.456  18.968  1.00 44.33  ? 102 VAL H CA  1 
ATOM   5609 C C   . VAL D 4 108 ? 18.653  -10.481 18.230  1.00 40.45  ? 102 VAL H C   1 
ATOM   5610 O O   . VAL D 4 108 ? 17.464  -10.251 17.980  1.00 45.39  ? 102 VAL H O   1 
ATOM   5611 C CB  . VAL D 4 108 ? 19.076  -9.359  20.444  1.00 39.50  ? 102 VAL H CB  1 
ATOM   5612 C CG1 . VAL D 4 108 ? 19.177  -10.721 21.111  1.00 49.84  ? 102 VAL H CG1 1 
ATOM   5613 C CG2 . VAL D 4 108 ? 19.930  -8.341  21.176  1.00 37.08  ? 102 VAL H CG2 1 
ATOM   5614 N N   . TRP D 4 109 ? 19.259  -11.614 17.893  1.00 38.10  ? 103 TRP H N   1 
ATOM   5615 C CA  . TRP D 4 109 ? 18.577  -12.673 17.168  1.00 39.12  ? 103 TRP H CA  1 
ATOM   5616 C C   . TRP D 4 109 ? 18.724  -13.990 17.913  1.00 46.60  ? 103 TRP H C   1 
ATOM   5617 O O   . TRP D 4 109 ? 19.755  -14.247 18.542  1.00 46.16  ? 103 TRP H O   1 
ATOM   5618 C CB  . TRP D 4 109 ? 19.134  -12.821 15.753  1.00 37.47  ? 103 TRP H CB  1 
ATOM   5619 C CG  . TRP D 4 109 ? 18.757  -11.711 14.833  1.00 45.57  ? 103 TRP H CG  1 
ATOM   5620 C CD1 . TRP D 4 109 ? 19.289  -10.454 14.799  1.00 46.13  ? 103 TRP H CD1 1 
ATOM   5621 C CD2 . TRP D 4 109 ? 17.772  -11.759 13.796  1.00 47.33  ? 103 TRP H CD2 1 
ATOM   5622 N NE1 . TRP D 4 109 ? 18.690  -9.715  13.807  1.00 42.52  ? 103 TRP H NE1 1 
ATOM   5623 C CE2 . TRP D 4 109 ? 17.755  -10.494 13.177  1.00 48.26  ? 103 TRP H CE2 1 
ATOM   5624 C CE3 . TRP D 4 109 ? 16.900  -12.749 13.333  1.00 38.96  ? 103 TRP H CE3 1 
ATOM   5625 C CZ2 . TRP D 4 109 ? 16.901  -10.194 12.119  1.00 51.53  ? 103 TRP H CZ2 1 
ATOM   5626 C CZ3 . TRP D 4 109 ? 16.055  -12.450 12.285  1.00 35.68  ? 103 TRP H CZ3 1 
ATOM   5627 C CH2 . TRP D 4 109 ? 16.060  -11.183 11.688  1.00 47.69  ? 103 TRP H CH2 1 
ATOM   5628 N N   . GLY D 4 110 ? 17.678  -14.815 17.847  1.00 39.73  ? 104 GLY H N   1 
ATOM   5629 C CA  . GLY D 4 110 ? 17.753  -16.165 18.357  1.00 34.11  ? 104 GLY H CA  1 
ATOM   5630 C C   . GLY D 4 110 ? 18.406  -17.108 17.367  1.00 39.80  ? 104 GLY H C   1 
ATOM   5631 O O   . GLY D 4 110 ? 18.718  -16.752 16.230  1.00 39.19  ? 104 GLY H O   1 
ATOM   5632 N N   . GLN D 4 111 ? 18.618  -18.347 17.814  1.00 38.19  ? 105 GLN H N   1 
ATOM   5633 C CA  . GLN D 4 111 ? 19.300  -19.314 16.962  1.00 43.62  ? 105 GLN H CA  1 
ATOM   5634 C C   . GLN D 4 111 ? 18.394  -19.856 15.864  1.00 42.69  ? 105 GLN H C   1 
ATOM   5635 O O   . GLN D 4 111 ? 18.895  -20.406 14.878  1.00 36.42  ? 105 GLN H O   1 
ATOM   5636 C CB  . GLN D 4 111 ? 19.869  -20.461 17.806  1.00 30.21  ? 105 GLN H CB  1 
ATOM   5637 C CG  . GLN D 4 111 ? 18.857  -21.490 18.290  1.00 34.38  ? 105 GLN H CG  1 
ATOM   5638 C CD  . GLN D 4 111 ? 18.019  -21.010 19.460  1.00 42.73  ? 105 GLN H CD  1 
ATOM   5639 O OE1 . GLN D 4 111 ? 18.122  -19.861 19.889  1.00 52.37  ? 105 GLN H OE1 1 
ATOM   5640 N NE2 . GLN D 4 111 ? 17.180  -21.897 19.983  1.00 44.91  ? 105 GLN H NE2 1 
ATOM   5641 N N   . GLY D 4 112 ? 17.088  -19.698 16.001  1.00 34.40  ? 106 GLY H N   1 
ATOM   5642 C CA  . GLY D 4 112 ? 16.162  -20.202 15.011  1.00 39.52  ? 106 GLY H CA  1 
ATOM   5643 C C   . GLY D 4 112 ? 15.559  -21.533 15.417  1.00 38.75  ? 106 GLY H C   1 
ATOM   5644 O O   . GLY D 4 112 ? 16.196  -22.365 16.075  1.00 34.90  ? 106 GLY H O   1 
ATOM   5645 N N   . THR D 4 113 ? 14.306  -21.739 15.018  1.00 37.62  ? 107 THR H N   1 
ATOM   5646 C CA  . THR D 4 113 ? 13.567  -22.967 15.282  1.00 38.20  ? 107 THR H CA  1 
ATOM   5647 C C   . THR D 4 113 ? 13.146  -23.571 13.949  1.00 46.17  ? 107 THR H C   1 
ATOM   5648 O O   . THR D 4 113 ? 12.432  -22.927 13.173  1.00 44.58  ? 107 THR H O   1 
ATOM   5649 C CB  . THR D 4 113 ? 12.339  -22.694 16.157  1.00 41.85  ? 107 THR H CB  1 
ATOM   5650 O OG1 . THR D 4 113 ? 12.755  -22.224 17.446  1.00 48.59  ? 107 THR H OG1 1 
ATOM   5651 C CG2 . THR D 4 113 ? 11.503  -23.955 16.322  1.00 33.90  ? 107 THR H CG2 1 
ATOM   5652 N N   . THR D 4 114 ? 13.579  -24.805 13.692  1.00 40.34  ? 108 THR H N   1 
ATOM   5653 C CA  . THR D 4 114 ? 13.250  -25.506 12.455  1.00 40.96  ? 108 THR H CA  1 
ATOM   5654 C C   . THR D 4 114 ? 11.917  -26.227 12.626  1.00 44.54  ? 108 THR H C   1 
ATOM   5655 O O   . THR D 4 114 ? 11.754  -27.026 13.555  1.00 46.92  ? 108 THR H O   1 
ATOM   5656 C CB  . THR D 4 114 ? 14.352  -26.499 12.082  1.00 43.28  ? 108 THR H CB  1 
ATOM   5657 O OG1 . THR D 4 114 ? 15.609  -25.817 11.999  1.00 54.61  ? 108 THR H OG1 1 
ATOM   5658 C CG2 . THR D 4 114 ? 14.053  -27.150 10.741  1.00 39.25  ? 108 THR H CG2 1 
ATOM   5659 N N   . VAL D 4 115 ? 10.971  -25.948 11.732  1.00 47.06  ? 109 VAL H N   1 
ATOM   5660 C CA  . VAL D 4 115 ? 9.632   -26.527 11.777  1.00 51.78  ? 109 VAL H CA  1 
ATOM   5661 C C   . VAL D 4 115 ? 9.395   -27.284 10.478  1.00 49.63  ? 109 VAL H C   1 
ATOM   5662 O O   . VAL D 4 115 ? 9.497   -26.705 9.390   1.00 46.70  ? 109 VAL H O   1 
ATOM   5663 C CB  . VAL D 4 115 ? 8.549   -25.453 11.983  1.00 43.15  ? 109 VAL H CB  1 
ATOM   5664 C CG1 . VAL D 4 115 ? 7.170   -26.062 11.823  1.00 44.23  ? 109 VAL H CG1 1 
ATOM   5665 C CG2 . VAL D 4 115 ? 8.690   -24.806 13.349  1.00 44.51  ? 109 VAL H CG2 1 
ATOM   5666 N N   . THR D 4 116 ? 9.061   -28.567 10.592  1.00 46.11  ? 110 THR H N   1 
ATOM   5667 C CA  . THR D 4 116 ? 8.787   -29.416 9.440   1.00 43.92  ? 110 THR H CA  1 
ATOM   5668 C C   . THR D 4 116 ? 7.354   -29.916 9.537   1.00 47.76  ? 110 THR H C   1 
ATOM   5669 O O   . THR D 4 116 ? 6.992   -30.582 10.512  1.00 55.09  ? 110 THR H O   1 
ATOM   5670 C CB  . THR D 4 116 ? 9.766   -30.591 9.375   1.00 43.81  ? 110 THR H CB  1 
ATOM   5671 O OG1 . THR D 4 116 ? 11.109  -30.093 9.376   1.00 46.73  ? 110 THR H OG1 1 
ATOM   5672 C CG2 . THR D 4 116 ? 9.534   -31.413 8.115   1.00 44.49  ? 110 THR H CG2 1 
ATOM   5673 N N   . VAL D 4 117 ? 6.545   -29.596 8.532   1.00 49.29  ? 111 VAL H N   1 
ATOM   5674 C CA  . VAL D 4 117 ? 5.159   -30.045 8.461   1.00 47.12  ? 111 VAL H CA  1 
ATOM   5675 C C   . VAL D 4 117 ? 5.046   -30.947 7.241   1.00 47.06  ? 111 VAL H C   1 
ATOM   5676 O O   . VAL D 4 117 ? 5.170   -30.478 6.103   1.00 58.69  ? 111 VAL H O   1 
ATOM   5677 C CB  . VAL D 4 117 ? 4.175   -28.870 8.382   1.00 47.11  ? 111 VAL H CB  1 
ATOM   5678 C CG1 . VAL D 4 117 ? 2.746   -29.374 8.339   1.00 47.44  ? 111 VAL H CG1 1 
ATOM   5679 C CG2 . VAL D 4 117 ? 4.375   -27.926 9.565   1.00 44.00  ? 111 VAL H CG2 1 
ATOM   5680 N N   . SER D 4 118 ? 4.811   -32.238 7.469   1.00 44.55  ? 112 SER H N   1 
ATOM   5681 C CA  . SER D 4 118 ? 4.791   -33.199 6.375   1.00 55.53  ? 112 SER H CA  1 
ATOM   5682 C C   . SER D 4 118 ? 3.865   -34.357 6.719   1.00 55.22  ? 112 SER H C   1 
ATOM   5683 O O   . SER D 4 118 ? 3.623   -34.653 7.891   1.00 46.38  ? 112 SER H O   1 
ATOM   5684 C CB  . SER D 4 118 ? 6.201   -33.723 6.068   1.00 47.39  ? 112 SER H CB  1 
ATOM   5685 O OG  . SER D 4 118 ? 6.160   -34.836 5.190   1.00 50.24  ? 112 SER H OG  1 
ATOM   5686 N N   . SER D 4 119 ? 3.344   -35.011 5.677   1.00 60.15  ? 113 SER H N   1 
ATOM   5687 C CA  . SER D 4 119 ? 2.518   -36.194 5.883   1.00 61.70  ? 113 SER H CA  1 
ATOM   5688 C C   . SER D 4 119 ? 3.346   -37.420 6.231   1.00 58.76  ? 113 SER H C   1 
ATOM   5689 O O   . SER D 4 119 ? 2.779   -38.429 6.664   1.00 55.05  ? 113 SER H O   1 
ATOM   5690 C CB  . SER D 4 119 ? 1.673   -36.481 4.637   1.00 54.12  ? 113 SER H CB  1 
ATOM   5691 O OG  . SER D 4 119 ? 2.484   -36.893 3.550   1.00 60.23  ? 113 SER H OG  1 
ATOM   5692 N N   . ALA D 4 120 ? 4.662   -37.347 6.067   1.00 51.72  ? 114 ALA H N   1 
ATOM   5693 C CA  . ALA D 4 120 ? 5.519   -38.507 6.216   1.00 44.45  ? 114 ALA H CA  1 
ATOM   5694 C C   . ALA D 4 120 ? 5.647   -38.900 7.685   1.00 51.84  ? 114 ALA H C   1 
ATOM   5695 O O   . ALA D 4 120 ? 5.329   -38.131 8.596   1.00 60.89  ? 114 ALA H O   1 
ATOM   5696 C CB  . ALA D 4 120 ? 6.893   -38.226 5.613   1.00 46.75  ? 114 ALA H CB  1 
ATOM   5697 N N   . SER D 4 121 ? 6.104   -40.129 7.907   1.00 56.88  ? 115 SER H N   1 
ATOM   5698 C CA  . SER D 4 121 ? 6.317   -40.666 9.241   1.00 54.00  ? 115 SER H CA  1 
ATOM   5699 C C   . SER D 4 121 ? 7.792   -40.990 9.419   1.00 49.52  ? 115 SER H C   1 
ATOM   5700 O O   . SER D 4 121 ? 8.540   -41.127 8.447   1.00 50.95  ? 115 SER H O   1 
ATOM   5701 C CB  . SER D 4 121 ? 5.472   -41.921 9.487   1.00 50.53  ? 115 SER H CB  1 
ATOM   5702 O OG  . SER D 4 121 ? 4.098   -41.664 9.265   1.00 64.15  ? 115 SER H OG  1 
ATOM   5703 N N   . THR D 4 122 ? 8.205   -41.111 10.679  1.00 36.97  ? 116 THR H N   1 
ATOM   5704 C CA  . THR D 4 122 ? 9.608   -41.343 10.994  1.00 34.51  ? 116 THR H CA  1 
ATOM   5705 C C   . THR D 4 122 ? 10.116  -42.626 10.345  1.00 35.80  ? 116 THR H C   1 
ATOM   5706 O O   . THR D 4 122 ? 9.661   -43.723 10.680  1.00 53.98  ? 116 THR H O   1 
ATOM   5707 C CB  . THR D 4 122 ? 9.810   -41.396 12.507  1.00 31.01  ? 116 THR H CB  1 
ATOM   5708 O OG1 . THR D 4 122 ? 9.311   -40.188 13.097  1.00 42.48  ? 116 THR H OG1 1 
ATOM   5709 C CG2 . THR D 4 122 ? 11.284  -41.542 12.835  1.00 32.94  ? 116 THR H CG2 1 
ATOM   5710 N N   . LYS D 4 123 ? 11.053  -42.492 9.406   1.00 34.21  ? 117 LYS H N   1 
ATOM   5711 C CA  . LYS D 4 123 ? 11.620  -43.618 8.674   1.00 37.87  ? 117 LYS H CA  1 
ATOM   5712 C C   . LYS D 4 123 ? 13.137  -43.559 8.780   1.00 40.10  ? 117 LYS H C   1 
ATOM   5713 O O   . LYS D 4 123 ? 13.737  -42.502 8.564   1.00 44.43  ? 117 LYS H O   1 
ATOM   5714 C CB  . LYS D 4 123 ? 11.173  -43.598 7.203   1.00 45.81  ? 117 LYS H CB  1 
ATOM   5715 C CG  . LYS D 4 123 ? 11.955  -44.517 6.265   1.00 36.43  ? 117 LYS H CG  1 
ATOM   5716 C CD  . LYS D 4 123 ? 11.815  -45.984 6.643   1.00 50.62  ? 117 LYS H CD  1 
ATOM   5717 C CE  . LYS D 4 123 ? 12.705  -46.863 5.771   1.00 73.50  ? 117 LYS H CE  1 
ATOM   5718 N NZ  . LYS D 4 123 ? 12.655  -48.301 6.165   1.00 65.79  ? 117 LYS H NZ  1 
ATOM   5719 N N   . GLY D 4 124 ? 13.751  -44.689 9.120   1.00 39.23  ? 118 GLY H N   1 
ATOM   5720 C CA  . GLY D 4 124 ? 15.185  -44.763 9.263   1.00 39.91  ? 118 GLY H CA  1 
ATOM   5721 C C   . GLY D 4 124 ? 15.913  -44.738 7.933   1.00 47.98  ? 118 GLY H C   1 
ATOM   5722 O O   . GLY D 4 124 ? 15.398  -45.187 6.902   1.00 43.04  ? 118 GLY H O   1 
ATOM   5723 N N   . PRO D 4 125 ? 17.135  -44.212 7.937   1.00 49.62  ? 119 PRO H N   1 
ATOM   5724 C CA  . PRO D 4 125 ? 17.908  -44.138 6.694   1.00 39.49  ? 119 PRO H CA  1 
ATOM   5725 C C   . PRO D 4 125 ? 18.442  -45.498 6.272   1.00 37.18  ? 119 PRO H C   1 
ATOM   5726 O O   . PRO D 4 125 ? 18.671  -46.388 7.094   1.00 43.23  ? 119 PRO H O   1 
ATOM   5727 C CB  . PRO D 4 125 ? 19.052  -43.182 7.048   1.00 31.02  ? 119 PRO H CB  1 
ATOM   5728 C CG  . PRO D 4 125 ? 19.235  -43.363 8.516   1.00 38.96  ? 119 PRO H CG  1 
ATOM   5729 C CD  . PRO D 4 125 ? 17.870  -43.651 9.085   1.00 55.86  ? 119 PRO H CD  1 
ATOM   5730 N N   . SER D 4 126 ? 18.640  -45.648 4.965   1.00 33.19  ? 120 SER H N   1 
ATOM   5731 C CA  . SER D 4 126 ? 19.319  -46.803 4.392   1.00 36.72  ? 120 SER H CA  1 
ATOM   5732 C C   . SER D 4 126 ? 20.681  -46.342 3.896   1.00 41.90  ? 120 SER H C   1 
ATOM   5733 O O   . SER D 4 126 ? 20.767  -45.407 3.092   1.00 45.87  ? 120 SER H O   1 
ATOM   5734 C CB  . SER D 4 126 ? 18.512  -47.423 3.251   1.00 35.85  ? 120 SER H CB  1 
ATOM   5735 O OG  . SER D 4 126 ? 17.224  -47.820 3.686   1.00 45.49  ? 120 SER H OG  1 
ATOM   5736 N N   . VAL D 4 127 ? 21.736  -46.993 4.373   1.00 42.06  ? 121 VAL H N   1 
ATOM   5737 C CA  . VAL D 4 127 ? 23.108  -46.596 4.088   1.00 36.37  ? 121 VAL H CA  1 
ATOM   5738 C C   . VAL D 4 127 ? 23.712  -47.597 3.118   1.00 42.14  ? 121 VAL H C   1 
ATOM   5739 O O   . VAL D 4 127 ? 23.702  -48.806 3.377   1.00 43.10  ? 121 VAL H O   1 
ATOM   5740 C CB  . VAL D 4 127 ? 23.946  -46.507 5.373   1.00 38.12  ? 121 VAL H CB  1 
ATOM   5741 C CG1 . VAL D 4 127 ? 25.314  -45.928 5.064   1.00 43.67  ? 121 VAL H CG1 1 
ATOM   5742 C CG2 . VAL D 4 127 ? 23.221  -45.675 6.419   1.00 35.03  ? 121 VAL H CG2 1 
ATOM   5743 N N   . PHE D 4 128 ? 24.238  -47.093 2.004   1.00 45.01  ? 122 PHE H N   1 
ATOM   5744 C CA  . PHE D 4 128 ? 24.877  -47.924 1.002   1.00 42.44  ? 122 PHE H CA  1 
ATOM   5745 C C   . PHE D 4 128 ? 26.262  -47.375 0.695   1.00 42.91  ? 122 PHE H C   1 
ATOM   5746 O O   . PHE D 4 128 ? 26.454  -46.154 0.666   1.00 49.34  ? 122 PHE H O   1 
ATOM   5747 C CB  . PHE D 4 128 ? 24.053  -47.976 -0.290  1.00 44.35  ? 122 PHE H CB  1 
ATOM   5748 C CG  . PHE D 4 128 ? 22.627  -48.386 -0.085  1.00 48.04  ? 122 PHE H CG  1 
ATOM   5749 C CD1 . PHE D 4 128 ? 22.309  -49.693 0.241   1.00 43.07  ? 122 PHE H CD1 1 
ATOM   5750 C CD2 . PHE D 4 128 ? 21.600  -47.468 -0.237  1.00 50.38  ? 122 PHE H CD2 1 
ATOM   5751 C CE1 . PHE D 4 128 ? 20.996  -50.076 0.424   1.00 42.43  ? 122 PHE H CE1 1 
ATOM   5752 C CE2 . PHE D 4 128 ? 20.284  -47.844 -0.057  1.00 48.99  ? 122 PHE H CE2 1 
ATOM   5753 C CZ  . PHE D 4 128 ? 19.981  -49.150 0.273   1.00 51.47  ? 122 PHE H CZ  1 
ATOM   5754 N N   . PRO D 4 129 ? 27.238  -48.241 0.450   1.00 49.01  ? 123 PRO H N   1 
ATOM   5755 C CA  . PRO D 4 129 ? 28.603  -47.766 0.212   1.00 49.48  ? 123 PRO H CA  1 
ATOM   5756 C C   . PRO D 4 129 ? 28.825  -47.323 -1.226  1.00 52.28  ? 123 PRO H C   1 
ATOM   5757 O O   . PRO D 4 129 ? 28.253  -47.869 -2.171  1.00 53.94  ? 123 PRO H O   1 
ATOM   5758 C CB  . PRO D 4 129 ? 29.457  -48.995 0.543   1.00 51.21  ? 123 PRO H CB  1 
ATOM   5759 C CG  . PRO D 4 129 ? 28.572  -50.148 0.175   1.00 49.05  ? 123 PRO H CG  1 
ATOM   5760 C CD  . PRO D 4 129 ? 27.158  -49.713 0.480   1.00 40.12  ? 123 PRO H CD  1 
ATOM   5761 N N   . LEU D 4 130 ? 29.681  -46.317 -1.379  1.00 41.13  ? 124 LEU H N   1 
ATOM   5762 C CA  . LEU D 4 130 ? 30.155  -45.872 -2.688  1.00 40.80  ? 124 LEU H CA  1 
ATOM   5763 C C   . LEU D 4 130 ? 31.601  -46.348 -2.817  1.00 52.03  ? 124 LEU H C   1 
ATOM   5764 O O   . LEU D 4 130 ? 32.543  -45.622 -2.493  1.00 56.07  ? 124 LEU H O   1 
ATOM   5765 C CB  . LEU D 4 130 ? 30.031  -44.356 -2.839  1.00 41.81  ? 124 LEU H CB  1 
ATOM   5766 C CG  . LEU D 4 130 ? 28.612  -43.783 -2.799  1.00 35.19  ? 124 LEU H CG  1 
ATOM   5767 C CD1 . LEU D 4 130 ? 28.647  -42.271 -2.867  1.00 37.94  ? 124 LEU H CD1 1 
ATOM   5768 C CD2 . LEU D 4 130 ? 27.779  -44.337 -3.937  1.00 37.20  ? 124 LEU H CD2 1 
ATOM   5769 N N   . ALA D 4 131 ? 31.769  -47.579 -3.296  1.00 49.68  ? 125 ALA H N   1 
ATOM   5770 C CA  . ALA D 4 131 ? 33.086  -48.198 -3.323  1.00 49.32  ? 125 ALA H CA  1 
ATOM   5771 C C   . ALA D 4 131 ? 33.997  -47.491 -4.324  1.00 54.69  ? 125 ALA H C   1 
ATOM   5772 O O   . ALA D 4 131 ? 33.543  -47.075 -5.396  1.00 62.08  ? 125 ALA H O   1 
ATOM   5773 C CB  . ALA D 4 131 ? 32.975  -49.680 -3.679  1.00 54.07  ? 125 ALA H CB  1 
ATOM   5774 N N   . PRO D 4 132 ? 35.280  -47.338 -4.005  1.00 51.18  ? 126 PRO H N   1 
ATOM   5775 C CA  . PRO D 4 132 ? 36.223  -46.774 -4.975  1.00 43.50  ? 126 PRO H CA  1 
ATOM   5776 C C   . PRO D 4 132 ? 36.566  -47.782 -6.062  1.00 62.01  ? 126 PRO H C   1 
ATOM   5777 O O   . PRO D 4 132 ? 36.376  -48.992 -5.917  1.00 59.31  ? 126 PRO H O   1 
ATOM   5778 C CB  . PRO D 4 132 ? 37.458  -46.439 -4.129  1.00 49.92  ? 126 PRO H CB  1 
ATOM   5779 C CG  . PRO D 4 132 ? 37.032  -46.606 -2.696  1.00 47.41  ? 126 PRO H CG  1 
ATOM   5780 C CD  . PRO D 4 132 ? 35.912  -47.588 -2.702  1.00 55.83  ? 126 PRO H CD  1 
ATOM   5781 N N   . SER D 4 133 ? 37.094  -47.257 -7.162  1.00 56.41  ? 127 SER H N   1 
ATOM   5782 C CA  . SER D 4 133 ? 37.507  -48.069 -8.300  1.00 57.71  ? 127 SER H CA  1 
ATOM   5783 C C   . SER D 4 133 ? 38.442  -47.230 -9.164  1.00 64.24  ? 127 SER H C   1 
ATOM   5784 O O   . SER D 4 133 ? 38.826  -46.116 -8.790  1.00 56.19  ? 127 SER H O   1 
ATOM   5785 C CB  . SER D 4 133 ? 36.292  -48.562 -9.091  1.00 59.94  ? 127 SER H CB  1 
ATOM   5786 O OG  . SER D 4 133 ? 35.511  -47.470 -9.547  1.00 57.26  ? 127 SER H OG  1 
ATOM   5787 N N   . SER D 4 134 ? 38.814  -47.770 -10.327 1.00 60.64  ? 128 SER H N   1 
ATOM   5788 C CA  . SER D 4 134 ? 39.538  -46.971 -11.307 1.00 67.21  ? 128 SER H CA  1 
ATOM   5789 C C   . SER D 4 134 ? 38.700  -45.798 -11.800 1.00 70.48  ? 128 SER H C   1 
ATOM   5790 O O   . SER D 4 134 ? 39.261  -44.785 -12.234 1.00 63.77  ? 128 SER H O   1 
ATOM   5791 C CB  . SER D 4 134 ? 39.977  -47.850 -12.482 1.00 61.41  ? 128 SER H CB  1 
ATOM   5792 O OG  . SER D 4 134 ? 38.872  -48.520 -13.065 1.00 66.32  ? 128 SER H OG  1 
ATOM   5793 N N   . LYS D 4 135 ? 37.372  -45.907 -11.718 1.00 67.79  ? 129 LYS H N   1 
ATOM   5794 C CA  . LYS D 4 135 ? 36.458  -44.831 -12.083 1.00 67.68  ? 129 LYS H CA  1 
ATOM   5795 C C   . LYS D 4 135 ? 36.327  -43.774 -10.995 1.00 70.30  ? 129 LYS H C   1 
ATOM   5796 O O   . LYS D 4 135 ? 35.632  -42.773 -11.205 1.00 60.65  ? 129 LYS H O   1 
ATOM   5797 C CB  . LYS D 4 135 ? 35.077  -45.408 -12.399 1.00 60.81  ? 129 LYS H CB  1 
ATOM   5798 C CG  . LYS D 4 135 ? 35.107  -46.712 -13.186 1.00 59.65  ? 129 LYS H CG  1 
ATOM   5799 C CD  . LYS D 4 135 ? 34.218  -47.766 -12.531 1.00 71.84  ? 129 LYS H CD  1 
ATOM   5800 C CE  . LYS D 4 135 ? 34.476  -49.160 -13.097 1.00 77.28  ? 129 LYS H CE  1 
ATOM   5801 N NZ  . LYS D 4 135 ? 33.663  -50.224 -12.430 1.00 50.76  ? 129 LYS H NZ  1 
ATOM   5802 N N   . SER D 4 136 ? 36.960  -43.986 -9.837  1.00 76.79  ? 130 SER H N   1 
ATOM   5803 C CA  . SER D 4 136 ? 36.938  -43.044 -8.723  1.00 62.57  ? 130 SER H CA  1 
ATOM   5804 C C   . SER D 4 136 ? 38.341  -42.578 -8.342  1.00 65.87  ? 130 SER H C   1 
ATOM   5805 O O   . SER D 4 136 ? 38.527  -42.000 -7.265  1.00 68.42  ? 130 SER H O   1 
ATOM   5806 C CB  . SER D 4 136 ? 36.244  -43.666 -7.509  1.00 45.65  ? 130 SER H CB  1 
ATOM   5807 O OG  . SER D 4 136 ? 35.096  -44.406 -7.888  1.00 66.43  ? 130 SER H OG  1 
ATOM   5808 N N   . THR D 4 137 ? 39.336  -42.824 -9.195  1.00 72.58  ? 131 THR H N   1 
ATOM   5809 C CA  . THR D 4 137 ? 40.730  -42.515 -8.896  1.00 63.97  ? 131 THR H CA  1 
ATOM   5810 C C   . THR D 4 137 ? 41.289  -41.556 -9.936  1.00 62.08  ? 131 THR H C   1 
ATOM   5811 O O   . THR D 4 137 ? 41.177  -41.804 -11.142 1.00 64.73  ? 131 THR H O   1 
ATOM   5812 C CB  . THR D 4 137 ? 41.584  -43.783 -8.854  1.00 51.91  ? 131 THR H CB  1 
ATOM   5813 O OG1 . THR D 4 137 ? 41.010  -44.717 -7.933  1.00 58.30  ? 131 THR H OG1 1 
ATOM   5814 C CG2 . THR D 4 137 ? 43.002  -43.451 -8.416  1.00 55.15  ? 131 THR H CG2 1 
ATOM   5815 N N   . SER D 4 138 ? 41.899  -40.470 -9.465  1.00 62.53  ? 132 SER H N   1 
ATOM   5816 C CA  . SER D 4 138 ? 42.575  -39.489 -10.311 1.00 68.63  ? 132 SER H CA  1 
ATOM   5817 C C   . SER D 4 138 ? 44.030  -39.432 -9.855  1.00 71.25  ? 132 SER H C   1 
ATOM   5818 O O   . SER D 4 138 ? 44.404  -38.596 -9.027  1.00 68.46  ? 132 SER H O   1 
ATOM   5819 C CB  . SER D 4 138 ? 41.895  -38.111 -10.232 1.00 66.18  ? 132 SER H CB  1 
ATOM   5820 O OG  . SER D 4 138 ? 42.039  -37.524 -8.948  1.00 62.88  ? 132 SER H OG  1 
ATOM   5821 N N   . GLY D 4 139 ? 44.853  -40.322 -10.404 1.00 77.12  ? 133 GLY H N   1 
ATOM   5822 C CA  . GLY D 4 139 ? 46.242  -40.405 -10.003 1.00 80.46  ? 133 GLY H CA  1 
ATOM   5823 C C   . GLY D 4 139 ? 46.407  -40.933 -8.593  1.00 74.41  ? 133 GLY H C   1 
ATOM   5824 O O   . GLY D 4 139 ? 46.058  -42.084 -8.310  1.00 62.55  ? 133 GLY H O   1 
ATOM   5825 N N   . GLY D 4 140 ? 46.934  -40.099 -7.700  1.00 65.47  ? 134 GLY H N   1 
ATOM   5826 C CA  . GLY D 4 140 ? 47.148  -40.454 -6.315  1.00 64.42  ? 134 GLY H CA  1 
ATOM   5827 C C   . GLY D 4 140 ? 45.973  -40.204 -5.397  1.00 64.53  ? 134 GLY H C   1 
ATOM   5828 O O   . GLY D 4 140 ? 46.103  -40.376 -4.181  1.00 68.73  ? 134 GLY H O   1 
ATOM   5829 N N   . THR D 4 141 ? 44.828  -39.803 -5.940  1.00 62.79  ? 135 THR H N   1 
ATOM   5830 C CA  . THR D 4 141 ? 43.640  -39.494 -5.157  1.00 63.95  ? 135 THR H CA  1 
ATOM   5831 C C   . THR D 4 141 ? 42.527  -40.463 -5.530  1.00 66.76  ? 135 THR H C   1 
ATOM   5832 O O   . THR D 4 141 ? 42.255  -40.675 -6.717  1.00 64.77  ? 135 THR H O   1 
ATOM   5833 C CB  . THR D 4 141 ? 43.195  -38.045 -5.394  1.00 65.41  ? 135 THR H CB  1 
ATOM   5834 O OG1 . THR D 4 141 ? 44.117  -37.147 -4.762  1.00 64.46  ? 135 THR H OG1 1 
ATOM   5835 C CG2 . THR D 4 141 ? 41.806  -37.808 -4.835  1.00 64.41  ? 135 THR H CG2 1 
ATOM   5836 N N   . ALA D 4 142 ? 41.895  -41.056 -4.520  1.00 54.66  ? 136 ALA H N   1 
ATOM   5837 C CA  . ALA D 4 142 ? 40.761  -41.949 -4.708  1.00 54.09  ? 136 ALA H CA  1 
ATOM   5838 C C   . ALA D 4 142 ? 39.554  -41.404 -3.956  1.00 56.33  ? 136 ALA H C   1 
ATOM   5839 O O   . ALA D 4 142 ? 39.687  -40.880 -2.845  1.00 60.48  ? 136 ALA H O   1 
ATOM   5840 C CB  . ALA D 4 142 ? 41.079  -43.369 -4.232  1.00 43.96  ? 136 ALA H CB  1 
ATOM   5841 N N   . ALA D 4 143 ? 38.380  -41.527 -4.567  1.00 49.57  ? 137 ALA H N   1 
ATOM   5842 C CA  . ALA D 4 143 ? 37.141  -40.990 -4.020  1.00 39.49  ? 137 ALA H CA  1 
ATOM   5843 C C   . ALA D 4 143 ? 36.245  -42.128 -3.554  1.00 49.42  ? 137 ALA H C   1 
ATOM   5844 O O   . ALA D 4 143 ? 36.024  -43.095 -4.292  1.00 55.66  ? 137 ALA H O   1 
ATOM   5845 C CB  . ALA D 4 143 ? 36.412  -40.133 -5.057  1.00 43.44  ? 137 ALA H CB  1 
ATOM   5846 N N   . LEU D 4 144 ? 35.734  -42.008 -2.331  1.00 36.16  ? 138 LEU H N   1 
ATOM   5847 C CA  . LEU D 4 144 ? 34.816  -42.981 -1.760  1.00 26.82  ? 138 LEU H CA  1 
ATOM   5848 C C   . LEU D 4 144 ? 33.784  -42.238 -0.930  1.00 32.37  ? 138 LEU H C   1 
ATOM   5849 O O   . LEU D 4 144 ? 33.966  -41.068 -0.586  1.00 42.51  ? 138 LEU H O   1 
ATOM   5850 C CB  . LEU D 4 144 ? 35.548  -44.020 -0.899  1.00 38.12  ? 138 LEU H CB  1 
ATOM   5851 C CG  . LEU D 4 144 ? 36.493  -43.509 0.192   1.00 43.44  ? 138 LEU H CG  1 
ATOM   5852 C CD1 . LEU D 4 144 ? 35.788  -43.388 1.542   1.00 37.45  ? 138 LEU H CD1 1 
ATOM   5853 C CD2 . LEU D 4 144 ? 37.716  -44.408 0.292   1.00 45.80  ? 138 LEU H CD2 1 
ATOM   5854 N N   . GLY D 4 145 ? 32.698  -42.924 -0.603  1.00 28.21  ? 139 GLY H N   1 
ATOM   5855 C CA  . GLY D 4 145 ? 31.669  -42.285 0.191   1.00 34.53  ? 139 GLY H CA  1 
ATOM   5856 C C   . GLY D 4 145 ? 30.556  -43.243 0.544   1.00 37.23  ? 139 GLY H C   1 
ATOM   5857 O O   . GLY D 4 145 ? 30.634  -44.447 0.291   1.00 37.75  ? 139 GLY H O   1 
ATOM   5858 N N   . CYS D 4 146 ? 29.510  -42.675 1.144   1.00 40.54  ? 140 CYS H N   1 
ATOM   5859 C CA  . CYS D 4 146 ? 28.329  -43.417 1.557   1.00 48.13  ? 140 CYS H CA  1 
ATOM   5860 C C   . CYS D 4 146 ? 27.077  -42.721 1.046   1.00 42.96  ? 140 CYS H C   1 
ATOM   5861 O O   . CYS D 4 146 ? 27.042  -41.497 0.893   1.00 51.97  ? 140 CYS H O   1 
ATOM   5862 C CB  . CYS D 4 146 ? 28.254  -43.558 3.084   1.00 38.21  ? 140 CYS H CB  1 
ATOM   5863 S SG  . CYS D 4 146 ? 29.373  -44.807 3.744   1.00 92.88  ? 140 CYS H SG  1 
ATOM   5864 N N   . LEU D 4 147 ? 26.047  -43.520 0.786   1.00 40.95  ? 141 LEU H N   1 
ATOM   5865 C CA  . LEU D 4 147 ? 24.759  -43.036 0.305   1.00 36.41  ? 141 LEU H CA  1 
ATOM   5866 C C   . LEU D 4 147 ? 23.716  -43.263 1.395   1.00 38.05  ? 141 LEU H C   1 
ATOM   5867 O O   . LEU D 4 147 ? 23.400  -44.410 1.730   1.00 36.20  ? 141 LEU H O   1 
ATOM   5868 C CB  . LEU D 4 147 ? 24.368  -43.746 -0.987  1.00 39.75  ? 141 LEU H CB  1 
ATOM   5869 C CG  . LEU D 4 147 ? 22.976  -43.442 -1.533  1.00 44.95  ? 141 LEU H CG  1 
ATOM   5870 C CD1 . LEU D 4 147 ? 22.856  -41.968 -1.889  1.00 45.55  ? 141 LEU H CD1 1 
ATOM   5871 C CD2 . LEU D 4 147 ? 22.691  -44.322 -2.737  1.00 34.78  ? 141 LEU H CD2 1 
ATOM   5872 N N   . VAL D 4 148 ? 23.184  -42.171 1.938   1.00 41.38  ? 142 VAL H N   1 
ATOM   5873 C CA  . VAL D 4 148 ? 22.151  -42.201 2.969   1.00 42.34  ? 142 VAL H CA  1 
ATOM   5874 C C   . VAL D 4 148 ? 20.838  -41.824 2.300   1.00 49.59  ? 142 VAL H C   1 
ATOM   5875 O O   . VAL D 4 148 ? 20.655  -40.674 1.879   1.00 51.79  ? 142 VAL H O   1 
ATOM   5876 C CB  . VAL D 4 148 ? 22.478  -41.247 4.126   1.00 36.25  ? 142 VAL H CB  1 
ATOM   5877 C CG1 . VAL D 4 148 ? 21.346  -41.223 5.141   1.00 45.12  ? 142 VAL H CG1 1 
ATOM   5878 C CG2 . VAL D 4 148 ? 23.787  -41.644 4.783   1.00 30.09  ? 142 VAL H CG2 1 
ATOM   5879 N N   . LYS D 4 149 ? 19.911  -42.776 2.213   1.00 40.90  ? 143 LYS H N   1 
ATOM   5880 C CA  . LYS D 4 149 ? 18.717  -42.594 1.403   1.00 49.45  ? 143 LYS H CA  1 
ATOM   5881 C C   . LYS D 4 149 ? 17.464  -42.989 2.174   1.00 45.38  ? 143 LYS H C   1 
ATOM   5882 O O   . LYS D 4 149 ? 17.492  -43.878 3.029   1.00 43.65  ? 143 LYS H O   1 
ATOM   5883 C CB  . LYS D 4 149 ? 18.806  -43.405 0.101   1.00 36.35  ? 143 LYS H CB  1 
ATOM   5884 C CG  . LYS D 4 149 ? 18.191  -42.685 -1.085  1.00 66.44  ? 143 LYS H CG  1 
ATOM   5885 C CD  . LYS D 4 149 ? 17.683  -43.648 -2.138  1.00 66.05  ? 143 LYS H CD  1 
ATOM   5886 C CE  . LYS D 4 149 ? 16.630  -42.977 -3.009  1.00 61.60  ? 143 LYS H CE  1 
ATOM   5887 N NZ  . LYS D 4 149 ? 15.753  -43.974 -3.681  1.00 61.30  ? 143 LYS H NZ  1 
ATOM   5888 N N   . ASP D 4 150 ? 16.362  -42.302 1.854   1.00 51.86  ? 144 ASP H N   1 
ATOM   5889 C CA  . ASP D 4 150 ? 15.014  -42.622 2.329   1.00 45.75  ? 144 ASP H CA  1 
ATOM   5890 C C   . ASP D 4 150 ? 14.930  -42.590 3.859   1.00 41.58  ? 144 ASP H C   1 
ATOM   5891 O O   . ASP D 4 150 ? 14.719  -43.605 4.525   1.00 53.38  ? 144 ASP H O   1 
ATOM   5892 C CB  . ASP D 4 150 ? 14.547  -43.976 1.785   1.00 53.45  ? 144 ASP H CB  1 
ATOM   5893 C CG  . ASP D 4 150 ? 14.477  -43.999 0.275   1.00 62.28  ? 144 ASP H CG  1 
ATOM   5894 O OD1 . ASP D 4 150 ? 14.540  -45.104 -0.307  1.00 64.82  ? 144 ASP H OD1 1 
ATOM   5895 O OD2 . ASP D 4 150 ? 14.376  -42.908 -0.329  1.00 56.69  ? 144 ASP H OD2 1 
ATOM   5896 N N   . TYR D 4 151 ? 15.098  -41.383 4.397   1.00 38.85  ? 145 TYR H N   1 
ATOM   5897 C CA  . TYR D 4 151 ? 14.933  -41.141 5.823   1.00 46.36  ? 145 TYR H CA  1 
ATOM   5898 C C   . TYR D 4 151 ? 14.049  -39.924 6.047   1.00 48.95  ? 145 TYR H C   1 
ATOM   5899 O O   . TYR D 4 151 ? 13.957  -39.034 5.197   1.00 50.77  ? 145 TYR H O   1 
ATOM   5900 C CB  . TYR D 4 151 ? 16.278  -40.931 6.540   1.00 48.62  ? 145 TYR H CB  1 
ATOM   5901 C CG  . TYR D 4 151 ? 17.051  -39.691 6.128   1.00 40.01  ? 145 TYR H CG  1 
ATOM   5902 C CD1 . TYR D 4 151 ? 16.856  -38.474 6.773   1.00 40.68  ? 145 TYR H CD1 1 
ATOM   5903 C CD2 . TYR D 4 151 ? 17.998  -39.745 5.112   1.00 39.58  ? 145 TYR H CD2 1 
ATOM   5904 C CE1 . TYR D 4 151 ? 17.571  -37.343 6.405   1.00 43.59  ? 145 TYR H CE1 1 
ATOM   5905 C CE2 . TYR D 4 151 ? 18.716  -38.623 4.740   1.00 41.99  ? 145 TYR H CE2 1 
ATOM   5906 C CZ  . TYR D 4 151 ? 18.501  -37.426 5.389   1.00 41.64  ? 145 TYR H CZ  1 
ATOM   5907 O OH  . TYR D 4 151 ? 19.218  -36.311 5.017   1.00 39.33  ? 145 TYR H OH  1 
ATOM   5908 N N   . PHE D 4 152 ? 13.402  -39.895 7.214   1.00 42.45  ? 146 PHE H N   1 
ATOM   5909 C CA  . PHE D 4 152 ? 12.580  -38.763 7.607   1.00 39.10  ? 146 PHE H CA  1 
ATOM   5910 C C   . PHE D 4 152 ? 12.466  -38.757 9.119   1.00 41.86  ? 146 PHE H C   1 
ATOM   5911 O O   . PHE D 4 152 ? 12.274  -39.826 9.714   1.00 52.42  ? 146 PHE H O   1 
ATOM   5912 C CB  . PHE D 4 152 ? 11.187  -38.835 6.974   1.00 44.79  ? 146 PHE H CB  1 
ATOM   5913 C CG  . PHE D 4 152 ? 10.327  -37.636 7.257   1.00 47.01  ? 146 PHE H CG  1 
ATOM   5914 C CD1 . PHE D 4 152 ? 9.522   -37.591 8.384   1.00 33.78  ? 146 PHE H CD1 1 
ATOM   5915 C CD2 . PHE D 4 152 ? 10.322  -36.555 6.392   1.00 48.13  ? 146 PHE H CD2 1 
ATOM   5916 C CE1 . PHE D 4 152 ? 8.732   -36.491 8.644   1.00 36.74  ? 146 PHE H CE1 1 
ATOM   5917 C CE2 . PHE D 4 152 ? 9.532   -35.451 6.647   1.00 48.97  ? 146 PHE H CE2 1 
ATOM   5918 C CZ  . PHE D 4 152 ? 8.737   -35.420 7.775   1.00 49.51  ? 146 PHE H CZ  1 
ATOM   5919 N N   . PRO D 4 153 ? 12.571  -37.601 9.770   1.00 40.51  ? 147 PRO H N   1 
ATOM   5920 C CA  . PRO D 4 153 ? 12.859  -36.283 9.202   1.00 47.54  ? 147 PRO H CA  1 
ATOM   5921 C C   . PRO D 4 153 ? 14.341  -35.952 9.287   1.00 44.53  ? 147 PRO H C   1 
ATOM   5922 O O   . PRO D 4 153 ? 15.159  -36.809 9.607   1.00 43.70  ? 147 PRO H O   1 
ATOM   5923 C CB  . PRO D 4 153 ? 12.017  -35.356 10.081  1.00 40.24  ? 147 PRO H CB  1 
ATOM   5924 C CG  . PRO D 4 153 ? 12.123  -35.999 11.439  1.00 40.58  ? 147 PRO H CG  1 
ATOM   5925 C CD  . PRO D 4 153 ? 12.162  -37.497 11.181  1.00 42.12  ? 147 PRO H CD  1 
ATOM   5926 N N   . GLU D 4 154 ? 14.698  -34.705 8.995   1.00 39.77  ? 148 GLU H N   1 
ATOM   5927 C CA  . GLU D 4 154 ? 16.045  -34.222 9.230   1.00 38.00  ? 148 GLU H CA  1 
ATOM   5928 C C   . GLU D 4 154 ? 16.278  -34.035 10.731  1.00 51.60  ? 148 GLU H C   1 
ATOM   5929 O O   . GLU D 4 154 ? 15.324  -33.910 11.505  1.00 51.75  ? 148 GLU H O   1 
ATOM   5930 C CB  . GLU D 4 154 ? 16.264  -32.910 8.479   1.00 36.37  ? 148 GLU H CB  1 
ATOM   5931 C CG  . GLU D 4 154 ? 16.489  -33.077 6.987   1.00 34.52  ? 148 GLU H CG  1 
ATOM   5932 C CD  . GLU D 4 154 ? 16.785  -31.761 6.293   1.00 60.09  ? 148 GLU H CD  1 
ATOM   5933 O OE1 . GLU D 4 154 ? 16.077  -30.768 6.567   1.00 65.80  ? 148 GLU H OE1 1 
ATOM   5934 O OE2 . GLU D 4 154 ? 17.732  -31.717 5.482   1.00 58.76  ? 148 GLU H OE2 1 
ATOM   5935 N N   . PRO D 4 155 ? 17.548  -34.013 11.175  1.00 49.79  ? 149 PRO H N   1 
ATOM   5936 C CA  . PRO D 4 155 ? 18.791  -34.132 10.410  1.00 49.52  ? 149 PRO H CA  1 
ATOM   5937 C C   . PRO D 4 155 ? 19.440  -35.506 10.499  1.00 42.69  ? 149 PRO H C   1 
ATOM   5938 O O   . PRO D 4 155 ? 19.046  -36.357 11.291  1.00 40.63  ? 149 PRO H O   1 
ATOM   5939 C CB  . PRO D 4 155 ? 19.674  -33.057 11.060  1.00 38.79  ? 149 PRO H CB  1 
ATOM   5940 C CG  . PRO D 4 155 ? 19.176  -32.965 12.513  1.00 38.30  ? 149 PRO H CG  1 
ATOM   5941 C CD  . PRO D 4 155 ? 17.846  -33.702 12.583  1.00 47.28  ? 149 PRO H CD  1 
ATOM   5942 N N   . VAL D 4 156 ? 20.457  -35.736 9.674   1.00 41.98  ? 150 VAL H N   1 
ATOM   5943 C CA  . VAL D 4 156 ? 21.281  -36.935 9.744   1.00 35.99  ? 150 VAL H CA  1 
ATOM   5944 C C   . VAL D 4 156 ? 22.732  -36.489 9.835   1.00 47.04  ? 150 VAL H C   1 
ATOM   5945 O O   . VAL D 4 156 ? 23.210  -35.740 8.974   1.00 58.38  ? 150 VAL H O   1 
ATOM   5946 C CB  . VAL D 4 156 ? 21.065  -37.858 8.534   1.00 40.09  ? 150 VAL H CB  1 
ATOM   5947 C CG1 . VAL D 4 156 ? 22.251  -38.788 8.355   1.00 51.08  ? 150 VAL H CG1 1 
ATOM   5948 C CG2 . VAL D 4 156 ? 19.794  -38.663 8.718   1.00 46.90  ? 150 VAL H CG2 1 
ATOM   5949 N N   . THR D 4 157 ? 23.428  -36.941 10.874  1.00 44.31  ? 151 THR H N   1 
ATOM   5950 C CA  . THR D 4 157 ? 24.833  -36.621 11.075  1.00 44.45  ? 151 THR H CA  1 
ATOM   5951 C C   . THR D 4 157 ? 25.688  -37.753 10.518  1.00 49.81  ? 151 THR H C   1 
ATOM   5952 O O   . THR D 4 157 ? 25.443  -38.927 10.816  1.00 50.76  ? 151 THR H O   1 
ATOM   5953 C CB  . THR D 4 157 ? 25.139  -36.393 12.557  1.00 47.14  ? 151 THR H CB  1 
ATOM   5954 O OG1 . THR D 4 157 ? 24.796  -37.562 13.311  1.00 40.01  ? 151 THR H OG1 1 
ATOM   5955 C CG2 . THR D 4 157 ? 24.342  -35.209 13.084  1.00 41.78  ? 151 THR H CG2 1 
ATOM   5956 N N   . VAL D 4 158 ? 26.674  -37.400 9.697   1.00 51.93  ? 152 VAL H N   1 
ATOM   5957 C CA  . VAL D 4 158 ? 27.554  -38.369 9.054   1.00 46.66  ? 152 VAL H CA  1 
ATOM   5958 C C   . VAL D 4 158 ? 28.989  -38.068 9.456   1.00 38.05  ? 152 VAL H C   1 
ATOM   5959 O O   . VAL D 4 158 ? 29.454  -36.931 9.316   1.00 41.58  ? 152 VAL H O   1 
ATOM   5960 C CB  . VAL D 4 158 ? 27.405  -38.351 7.523   1.00 35.26  ? 152 VAL H CB  1 
ATOM   5961 C CG1 . VAL D 4 158 ? 28.357  -39.355 6.893   1.00 28.81  ? 152 VAL H CG1 1 
ATOM   5962 C CG2 . VAL D 4 158 ? 25.968  -38.649 7.131   1.00 42.10  ? 152 VAL H CG2 1 
ATOM   5963 N N   . SER D 4 159 ? 29.687  -39.088 9.946   1.00 46.15  ? 153 SER H N   1 
ATOM   5964 C CA  . SER D 4 159 ? 31.082  -38.974 10.336  1.00 45.82  ? 153 SER H CA  1 
ATOM   5965 C C   . SER D 4 159 ? 31.888  -40.057 9.636   1.00 47.39  ? 153 SER H C   1 
ATOM   5966 O O   . SER D 4 159 ? 31.346  -41.063 9.173   1.00 54.68  ? 153 SER H O   1 
ATOM   5967 C CB  . SER D 4 159 ? 31.257  -39.092 11.853  1.00 45.10  ? 153 SER H CB  1 
ATOM   5968 O OG  . SER D 4 159 ? 30.509  -38.097 12.524  1.00 69.90  ? 153 SER H OG  1 
ATOM   5969 N N   . TRP D 4 160 ? 33.197  -39.841 9.562   1.00 39.18  ? 154 TRP H N   1 
ATOM   5970 C CA  . TRP D 4 160 ? 34.103  -40.793 8.938   1.00 47.52  ? 154 TRP H CA  1 
ATOM   5971 C C   . TRP D 4 160 ? 35.194  -41.179 9.923   1.00 51.23  ? 154 TRP H C   1 
ATOM   5972 O O   . TRP D 4 160 ? 35.871  -40.307 10.481  1.00 53.55  ? 154 TRP H O   1 
ATOM   5973 C CB  . TRP D 4 160 ? 34.706  -40.217 7.656   1.00 41.19  ? 154 TRP H CB  1 
ATOM   5974 C CG  . TRP D 4 160 ? 33.732  -40.200 6.521   1.00 46.44  ? 154 TRP H CG  1 
ATOM   5975 C CD1 . TRP D 4 160 ? 32.911  -39.171 6.159   1.00 50.20  ? 154 TRP H CD1 1 
ATOM   5976 C CD2 . TRP D 4 160 ? 33.461  -41.270 5.606   1.00 45.48  ? 154 TRP H CD2 1 
ATOM   5977 N NE1 . TRP D 4 160 ? 32.153  -39.531 5.068   1.00 48.70  ? 154 TRP H NE1 1 
ATOM   5978 C CE2 . TRP D 4 160 ? 32.469  -40.816 4.713   1.00 50.51  ? 154 TRP H CE2 1 
ATOM   5979 C CE3 . TRP D 4 160 ? 33.964  -42.566 5.452   1.00 38.99  ? 154 TRP H CE3 1 
ATOM   5980 C CZ2 . TRP D 4 160 ? 31.977  -41.609 3.679   1.00 42.31  ? 154 TRP H CZ2 1 
ATOM   5981 C CZ3 . TRP D 4 160 ? 33.470  -43.351 4.428   1.00 38.18  ? 154 TRP H CZ3 1 
ATOM   5982 C CH2 . TRP D 4 160 ? 32.488  -42.871 3.555   1.00 40.12  ? 154 TRP H CH2 1 
ATOM   5983 N N   . ASN D 4 161 ? 35.366  -42.487 10.119  1.00 44.89  ? 155 ASN H N   1 
ATOM   5984 C CA  . ASN D 4 161 ? 36.308  -43.021 11.098  1.00 40.91  ? 155 ASN H CA  1 
ATOM   5985 C C   . ASN D 4 161 ? 36.045  -42.426 12.478  1.00 43.43  ? 155 ASN H C   1 
ATOM   5986 O O   . ASN D 4 161 ? 36.962  -42.001 13.183  1.00 45.38  ? 155 ASN H O   1 
ATOM   5987 C CB  . ASN D 4 161 ? 37.754  -42.791 10.656  1.00 43.63  ? 155 ASN H CB  1 
ATOM   5988 C CG  . ASN D 4 161 ? 38.127  -43.610 9.428   1.00 53.45  ? 155 ASN H CG  1 
ATOM   5989 O OD1 . ASN D 4 161 ? 37.457  -44.588 9.092   1.00 39.81  ? 155 ASN H OD1 1 
ATOM   5990 N ND2 . ASN D 4 161 ? 39.206  -43.218 8.760   1.00 58.36  ? 155 ASN H ND2 1 
ATOM   5991 N N   . SER D 4 162 ? 34.764  -42.384 12.851  1.00 46.29  ? 156 SER H N   1 
ATOM   5992 C CA  . SER D 4 162 ? 34.317  -41.889 14.154  1.00 48.54  ? 156 SER H CA  1 
ATOM   5993 C C   . SER D 4 162 ? 34.781  -40.455 14.405  1.00 49.06  ? 156 SER H C   1 
ATOM   5994 O O   . SER D 4 162 ? 35.157  -40.089 15.521  1.00 49.98  ? 156 SER H O   1 
ATOM   5995 C CB  . SER D 4 162 ? 34.775  -42.819 15.278  1.00 51.44  ? 156 SER H CB  1 
ATOM   5996 O OG  . SER D 4 162 ? 34.323  -44.142 15.048  1.00 71.69  ? 156 SER H OG  1 
ATOM   5997 N N   . GLY D 4 163 ? 34.744  -39.632 13.358  1.00 48.53  ? 157 GLY H N   1 
ATOM   5998 C CA  . GLY D 4 163 ? 35.138  -38.244 13.455  1.00 47.95  ? 157 GLY H CA  1 
ATOM   5999 C C   . GLY D 4 163 ? 36.622  -37.982 13.337  1.00 48.36  ? 157 GLY H C   1 
ATOM   6000 O O   . GLY D 4 163 ? 37.035  -36.818 13.418  1.00 59.26  ? 157 GLY H O   1 
ATOM   6001 N N   . ALA D 4 164 ? 37.440  -39.019 13.150  1.00 43.89  ? 158 ALA H N   1 
ATOM   6002 C CA  . ALA D 4 164 ? 38.879  -38.821 13.024  1.00 44.46  ? 158 ALA H CA  1 
ATOM   6003 C C   . ALA D 4 164 ? 39.253  -38.253 11.661  1.00 47.07  ? 158 ALA H C   1 
ATOM   6004 O O   . ALA D 4 164 ? 40.158  -37.416 11.562  1.00 49.62  ? 158 ALA H O   1 
ATOM   6005 C CB  . ALA D 4 164 ? 39.607  -40.140 13.266  1.00 43.11  ? 158 ALA H CB  1 
ATOM   6006 N N   . LEU D 4 165 ? 38.572  -38.695 10.607  1.00 46.09  ? 159 LEU H N   1 
ATOM   6007 C CA  . LEU D 4 165 ? 38.844  -38.246 9.246   1.00 49.45  ? 159 LEU H CA  1 
ATOM   6008 C C   . LEU D 4 165 ? 37.939  -37.060 8.931   1.00 52.87  ? 159 LEU H C   1 
ATOM   6009 O O   . LEU D 4 165 ? 36.733  -37.229 8.726   1.00 50.64  ? 159 LEU H O   1 
ATOM   6010 C CB  . LEU D 4 165 ? 38.624  -39.388 8.259   1.00 44.68  ? 159 LEU H CB  1 
ATOM   6011 C CG  . LEU D 4 165 ? 38.876  -39.099 6.782   1.00 44.43  ? 159 LEU H CG  1 
ATOM   6012 C CD1 . LEU D 4 165 ? 40.254  -38.486 6.568   1.00 39.72  ? 159 LEU H CD1 1 
ATOM   6013 C CD2 . LEU D 4 165 ? 38.733  -40.391 6.005   1.00 31.73  ? 159 LEU H CD2 1 
ATOM   6014 N N   . THR D 4 166 ? 38.521  -35.860 8.891   1.00 53.86  ? 160 THR H N   1 
ATOM   6015 C CA  . THR D 4 166 ? 37.756  -34.640 8.678   1.00 44.86  ? 160 THR H CA  1 
ATOM   6016 C C   . THR D 4 166 ? 38.217  -33.810 7.489   1.00 50.23  ? 160 THR H C   1 
ATOM   6017 O O   . THR D 4 166 ? 37.539  -32.835 7.145   1.00 66.67  ? 160 THR H O   1 
ATOM   6018 C CB  . THR D 4 166 ? 37.795  -33.751 9.933   1.00 40.65  ? 160 THR H CB  1 
ATOM   6019 O OG1 . THR D 4 166 ? 39.151  -33.389 10.224  1.00 69.93  ? 160 THR H OG1 1 
ATOM   6020 C CG2 . THR D 4 166 ? 37.202  -34.479 11.127  1.00 48.11  ? 160 THR H CG2 1 
ATOM   6021 N N   . SER D 4 167 ? 39.339  -34.145 6.860   1.00 45.19  ? 161 SER H N   1 
ATOM   6022 C CA  . SER D 4 167 ? 39.839  -33.388 5.721   1.00 48.07  ? 161 SER H CA  1 
ATOM   6023 C C   . SER D 4 167 ? 39.432  -34.092 4.435   1.00 51.27  ? 161 SER H C   1 
ATOM   6024 O O   . SER D 4 167 ? 39.604  -35.308 4.304   1.00 54.98  ? 161 SER H O   1 
ATOM   6025 C CB  . SER D 4 167 ? 41.360  -33.227 5.781   1.00 47.90  ? 161 SER H CB  1 
ATOM   6026 O OG  . SER D 4 167 ? 42.019  -34.420 5.390   1.00 73.45  ? 161 SER H OG  1 
ATOM   6027 N N   . GLY D 4 168 ? 38.888  -33.325 3.494   1.00 42.80  ? 162 GLY H N   1 
ATOM   6028 C CA  . GLY D 4 168 ? 38.453  -33.867 2.227   1.00 47.46  ? 162 GLY H CA  1 
ATOM   6029 C C   . GLY D 4 168 ? 37.044  -34.416 2.211   1.00 45.46  ? 162 GLY H C   1 
ATOM   6030 O O   . GLY D 4 168 ? 36.580  -34.848 1.147   1.00 42.40  ? 162 GLY H O   1 
ATOM   6031 N N   . VAL D 4 169 ? 36.350  -34.410 3.347   1.00 41.89  ? 163 VAL H N   1 
ATOM   6032 C CA  . VAL D 4 169 ? 34.978  -34.901 3.415   1.00 45.70  ? 163 VAL H CA  1 
ATOM   6033 C C   . VAL D 4 169 ? 34.031  -33.848 2.856   1.00 43.79  ? 163 VAL H C   1 
ATOM   6034 O O   . VAL D 4 169 ? 34.244  -32.640 3.016   1.00 40.46  ? 163 VAL H O   1 
ATOM   6035 C CB  . VAL D 4 169 ? 34.603  -35.276 4.862   1.00 43.49  ? 163 VAL H CB  1 
ATOM   6036 C CG1 . VAL D 4 169 ? 35.280  -36.574 5.271   1.00 46.73  ? 163 VAL H CG1 1 
ATOM   6037 C CG2 . VAL D 4 169 ? 34.985  -34.157 5.812   1.00 55.88  ? 163 VAL H CG2 1 
ATOM   6038 N N   . HIS D 4 170 ? 32.976  -34.312 2.187   1.00 51.73  ? 164 HIS H N   1 
ATOM   6039 C CA  . HIS D 4 170 ? 31.928  -33.441 1.651   1.00 39.41  ? 164 HIS H CA  1 
ATOM   6040 C C   . HIS D 4 170 ? 30.591  -34.127 1.911   1.00 39.46  ? 164 HIS H C   1 
ATOM   6041 O O   . HIS D 4 170 ? 30.238  -35.086 1.221   1.00 47.04  ? 164 HIS H O   1 
ATOM   6042 C CB  . HIS D 4 170 ? 32.124  -33.170 0.164   1.00 38.33  ? 164 HIS H CB  1 
ATOM   6043 C CG  . HIS D 4 170 ? 33.293  -32.288 -0.145  1.00 37.60  ? 164 HIS H CG  1 
ATOM   6044 N ND1 . HIS D 4 170 ? 33.370  -30.980 0.283   1.00 41.40  ? 164 HIS H ND1 1 
ATOM   6045 C CD2 . HIS D 4 170 ? 34.425  -32.521 -0.850  1.00 37.42  ? 164 HIS H CD2 1 
ATOM   6046 C CE1 . HIS D 4 170 ? 34.504  -30.448 -0.137  1.00 52.42  ? 164 HIS H CE1 1 
ATOM   6047 N NE2 . HIS D 4 170 ? 35.162  -31.362 -0.828  1.00 54.69  ? 164 HIS H NE2 1 
ATOM   6048 N N   . THR D 4 171 ? 29.857  -33.641 2.904   1.00 28.10  ? 165 THR H N   1 
ATOM   6049 C CA  . THR D 4 171 ? 28.512  -34.131 3.196   1.00 31.72  ? 165 THR H CA  1 
ATOM   6050 C C   . THR D 4 171 ? 27.530  -33.197 2.494   1.00 35.98  ? 165 THR H C   1 
ATOM   6051 O O   . THR D 4 171 ? 27.310  -32.065 2.931   1.00 46.32  ? 165 THR H O   1 
ATOM   6052 C CB  . THR D 4 171 ? 28.271  -34.194 4.700   1.00 33.55  ? 165 THR H CB  1 
ATOM   6053 O OG1 . THR D 4 171 ? 29.243  -35.059 5.300   1.00 41.63  ? 165 THR H OG1 1 
ATOM   6054 C CG2 . THR D 4 171 ? 26.877  -34.732 5.001   1.00 33.59  ? 165 THR H CG2 1 
ATOM   6055 N N   . PHE D 4 172 ? 26.952  -33.671 1.393   1.00 27.94  ? 166 PHE H N   1 
ATOM   6056 C CA  . PHE D 4 172 ? 26.060  -32.840 0.603   1.00 35.57  ? 166 PHE H CA  1 
ATOM   6057 C C   . PHE D 4 172 ? 24.746  -32.596 1.341   1.00 32.34  ? 166 PHE H C   1 
ATOM   6058 O O   . PHE D 4 172 ? 24.280  -33.452 2.096   1.00 38.51  ? 166 PHE H O   1 
ATOM   6059 C CB  . PHE D 4 172 ? 25.788  -33.491 -0.750  1.00 31.84  ? 166 PHE H CB  1 
ATOM   6060 C CG  . PHE D 4 172 ? 27.007  -33.606 -1.613  1.00 28.77  ? 166 PHE H CG  1 
ATOM   6061 C CD1 . PHE D 4 172 ? 27.370  -32.572 -2.458  1.00 27.54  ? 166 PHE H CD1 1 
ATOM   6062 C CD2 . PHE D 4 172 ? 27.800  -34.737 -1.566  1.00 37.50  ? 166 PHE H CD2 1 
ATOM   6063 C CE1 . PHE D 4 172 ? 28.495  -32.667 -3.246  1.00 36.21  ? 166 PHE H CE1 1 
ATOM   6064 C CE2 . PHE D 4 172 ? 28.931  -34.840 -2.353  1.00 39.95  ? 166 PHE H CE2 1 
ATOM   6065 C CZ  . PHE D 4 172 ? 29.278  -33.803 -3.194  1.00 44.45  ? 166 PHE H CZ  1 
ATOM   6066 N N   . PRO D 4 173 ? 24.137  -31.423 1.149   1.00 35.03  ? 167 PRO H N   1 
ATOM   6067 C CA  . PRO D 4 173 ? 22.850  -31.144 1.796   1.00 44.38  ? 167 PRO H CA  1 
ATOM   6068 C C   . PRO D 4 173 ? 21.774  -32.128 1.359   1.00 35.40  ? 167 PRO H C   1 
ATOM   6069 O O   . PRO D 4 173 ? 21.768  -32.618 0.228   1.00 32.12  ? 167 PRO H O   1 
ATOM   6070 C CB  . PRO D 4 173 ? 22.524  -29.720 1.336   1.00 31.23  ? 167 PRO H CB  1 
ATOM   6071 C CG  . PRO D 4 173 ? 23.856  -29.112 1.043   1.00 33.14  ? 167 PRO H CG  1 
ATOM   6072 C CD  . PRO D 4 173 ? 24.699  -30.229 0.494   1.00 28.27  ? 167 PRO H CD  1 
ATOM   6073 N N   . ALA D 4 174 ? 20.862  -32.424 2.280   1.00 35.64  ? 168 ALA H N   1 
ATOM   6074 C CA  . ALA D 4 174 ? 19.800  -33.372 1.982   1.00 37.89  ? 168 ALA H CA  1 
ATOM   6075 C C   . ALA D 4 174 ? 18.879  -32.819 0.901   1.00 40.70  ? 168 ALA H C   1 
ATOM   6076 O O   . ALA D 4 174 ? 18.673  -31.609 0.783   1.00 44.85  ? 168 ALA H O   1 
ATOM   6077 C CB  . ALA D 4 174 ? 19.000  -33.697 3.242   1.00 45.55  ? 168 ALA H CB  1 
ATOM   6078 N N   . VAL D 4 175 ? 18.336  -33.724 0.094   1.00 38.51  ? 169 VAL H N   1 
ATOM   6079 C CA  . VAL D 4 175 ? 17.386  -33.380 -0.955  1.00 37.83  ? 169 VAL H CA  1 
ATOM   6080 C C   . VAL D 4 175 ? 16.078  -34.094 -0.651  1.00 39.19  ? 169 VAL H C   1 
ATOM   6081 O O   . VAL D 4 175 ? 16.057  -35.322 -0.496  1.00 44.78  ? 169 VAL H O   1 
ATOM   6082 C CB  . VAL D 4 175 ? 17.909  -33.757 -2.350  1.00 35.06  ? 169 VAL H CB  1 
ATOM   6083 C CG1 . VAL D 4 175 ? 16.810  -33.594 -3.389  1.00 39.85  ? 169 VAL H CG1 1 
ATOM   6084 C CG2 . VAL D 4 175 ? 19.127  -32.910 -2.710  1.00 40.46  ? 169 VAL H CG2 1 
ATOM   6085 N N   . LEU D 4 176 ? 14.990  -33.330 -0.566  1.00 39.23  ? 170 LEU H N   1 
ATOM   6086 C CA  . LEU D 4 176 ? 13.670  -33.902 -0.323  1.00 40.14  ? 170 LEU H CA  1 
ATOM   6087 C C   . LEU D 4 176 ? 13.182  -34.565 -1.603  1.00 37.99  ? 170 LEU H C   1 
ATOM   6088 O O   . LEU D 4 176 ? 12.920  -33.891 -2.604  1.00 34.00  ? 170 LEU H O   1 
ATOM   6089 C CB  . LEU D 4 176 ? 12.691  -32.830 0.145   1.00 37.13  ? 170 LEU H CB  1 
ATOM   6090 C CG  . LEU D 4 176 ? 11.265  -33.314 0.418   1.00 32.57  ? 170 LEU H CG  1 
ATOM   6091 C CD1 . LEU D 4 176 ? 11.263  -34.461 1.416   1.00 35.46  ? 170 LEU H CD1 1 
ATOM   6092 C CD2 . LEU D 4 176 ? 10.413  -32.165 0.922   1.00 24.74  ? 170 LEU H CD2 1 
ATOM   6093 N N   . GLN D 4 177 ? 13.060  -35.886 -1.571  1.00 45.46  ? 171 GLN H N   1 
ATOM   6094 C CA  . GLN D 4 177 ? 12.662  -36.627 -2.752  1.00 50.29  ? 171 GLN H CA  1 
ATOM   6095 C C   . GLN D 4 177 ? 11.156  -36.542 -2.961  1.00 54.92  ? 171 GLN H C   1 
ATOM   6096 O O   . GLN D 4 177 ? 10.390  -36.208 -2.052  1.00 47.91  ? 171 GLN H O   1 
ATOM   6097 C CB  . GLN D 4 177 ? 13.095  -38.085 -2.633  1.00 47.72  ? 171 GLN H CB  1 
ATOM   6098 C CG  . GLN D 4 177 ? 14.532  -38.226 -2.192  1.00 47.25  ? 171 GLN H CG  1 
ATOM   6099 C CD  . GLN D 4 177 ? 15.049  -39.633 -2.336  1.00 61.40  ? 171 GLN H CD  1 
ATOM   6100 O OE1 . GLN D 4 177 ? 15.792  -39.938 -3.269  1.00 76.61  ? 171 GLN H OE1 1 
ATOM   6101 N NE2 . GLN D 4 177 ? 14.665  -40.504 -1.410  1.00 62.14  ? 171 GLN H NE2 1 
ATOM   6102 N N   . SER D 4 178 ? 10.735  -36.873 -4.182  1.00 65.42  ? 172 SER H N   1 
ATOM   6103 C CA  . SER D 4 178 ? 9.319   -36.858 -4.524  1.00 51.93  ? 172 SER H CA  1 
ATOM   6104 C C   . SER D 4 178 ? 8.519   -37.887 -3.736  1.00 47.22  ? 172 SER H C   1 
ATOM   6105 O O   . SER D 4 178 ? 7.287   -37.806 -3.723  1.00 51.82  ? 172 SER H O   1 
ATOM   6106 C CB  . SER D 4 178 ? 9.147   -37.085 -6.028  1.00 52.20  ? 172 SER H CB  1 
ATOM   6107 O OG  . SER D 4 178 ? 10.123  -37.985 -6.529  1.00 85.45  ? 172 SER H OG  1 
ATOM   6108 N N   . SER D 4 179 ? 9.182   -38.835 -3.074  1.00 53.93  ? 173 SER H N   1 
ATOM   6109 C CA  . SER D 4 179 ? 8.516   -39.792 -2.201  1.00 50.40  ? 173 SER H CA  1 
ATOM   6110 C C   . SER D 4 179 ? 8.255   -39.240 -0.805  1.00 59.39  ? 173 SER H C   1 
ATOM   6111 O O   . SER D 4 179 ? 7.670   -39.948 0.022   1.00 68.26  ? 173 SER H O   1 
ATOM   6112 C CB  . SER D 4 179 ? 9.342   -41.079 -2.095  1.00 60.20  ? 173 SER H CB  1 
ATOM   6113 O OG  . SER D 4 179 ? 10.583  -40.847 -1.445  1.00 64.72  ? 173 SER H OG  1 
ATOM   6114 N N   . GLY D 4 180 ? 8.672   -38.008 -0.518  1.00 48.85  ? 174 GLY H N   1 
ATOM   6115 C CA  . GLY D 4 180 ? 8.490   -37.425 0.793   1.00 44.89  ? 174 GLY H CA  1 
ATOM   6116 C C   . GLY D 4 180 ? 9.603   -37.700 1.781   1.00 48.32  ? 174 GLY H C   1 
ATOM   6117 O O   . GLY D 4 180 ? 9.549   -37.187 2.907   1.00 44.51  ? 174 GLY H O   1 
ATOM   6118 N N   . LEU D 4 181 ? 10.604  -38.488 1.402   1.00 41.57  ? 175 LEU H N   1 
ATOM   6119 C CA  . LEU D 4 181 ? 11.741  -38.798 2.251   1.00 40.83  ? 175 LEU H CA  1 
ATOM   6120 C C   . LEU D 4 181 ? 12.977  -38.051 1.765   1.00 45.17  ? 175 LEU H C   1 
ATOM   6121 O O   . LEU D 4 181 ? 13.052  -37.612 0.614   1.00 38.78  ? 175 LEU H O   1 
ATOM   6122 C CB  . LEU D 4 181 ? 12.016  -40.305 2.271   1.00 53.46  ? 175 LEU H CB  1 
ATOM   6123 C CG  . LEU D 4 181 ? 10.835  -41.186 2.675   1.00 45.96  ? 175 LEU H CG  1 
ATOM   6124 C CD1 . LEU D 4 181 ? 11.256  -42.643 2.778   1.00 45.93  ? 175 LEU H CD1 1 
ATOM   6125 C CD2 . LEU D 4 181 ? 10.253  -40.698 3.987   1.00 34.46  ? 175 LEU H CD2 1 
ATOM   6126 N N   . TYR D 4 182 ? 13.952  -37.916 2.660   1.00 42.79  ? 176 TYR H N   1 
ATOM   6127 C CA  . TYR D 4 182 ? 15.197  -37.220 2.372   1.00 33.66  ? 176 TYR H CA  1 
ATOM   6128 C C   . TYR D 4 182 ? 16.285  -38.202 1.959   1.00 42.84  ? 176 TYR H C   1 
ATOM   6129 O O   . TYR D 4 182 ? 16.286  -39.368 2.362   1.00 48.83  ? 176 TYR H O   1 
ATOM   6130 C CB  . TYR D 4 182 ? 15.674  -36.418 3.584   1.00 30.58  ? 176 TYR H CB  1 
ATOM   6131 C CG  . TYR D 4 182 ? 14.762  -35.277 3.961   1.00 39.66  ? 176 TYR H CG  1 
ATOM   6132 C CD1 . TYR D 4 182 ? 14.787  -34.085 3.252   1.00 36.72  ? 176 TYR H CD1 1 
ATOM   6133 C CD2 . TYR D 4 182 ? 13.877  -35.391 5.024   1.00 39.96  ? 176 TYR H CD2 1 
ATOM   6134 C CE1 . TYR D 4 182 ? 13.953  -33.038 3.588   1.00 36.50  ? 176 TYR H CE1 1 
ATOM   6135 C CE2 . TYR D 4 182 ? 13.038  -34.348 5.369   1.00 41.81  ? 176 TYR H CE2 1 
ATOM   6136 C CZ  . TYR D 4 182 ? 13.081  -33.173 4.646   1.00 44.18  ? 176 TYR H CZ  1 
ATOM   6137 O OH  . TYR D 4 182 ? 12.251  -32.128 4.979   1.00 50.41  ? 176 TYR H OH  1 
ATOM   6138 N N   . SER D 4 183 ? 17.215  -37.713 1.143   1.00 42.80  ? 177 SER H N   1 
ATOM   6139 C CA  . SER D 4 183 ? 18.382  -38.475 0.730   1.00 43.27  ? 177 SER H CA  1 
ATOM   6140 C C   . SER D 4 183 ? 19.618  -37.598 0.859   1.00 39.69  ? 177 SER H C   1 
ATOM   6141 O O   . SER D 4 183 ? 19.542  -36.371 0.751   1.00 44.02  ? 177 SER H O   1 
ATOM   6142 C CB  . SER D 4 183 ? 18.235  -38.991 -0.706  1.00 42.28  ? 177 SER H CB  1 
ATOM   6143 O OG  . SER D 4 183 ? 19.389  -39.701 -1.115  1.00 56.20  ? 177 SER H OG  1 
ATOM   6144 N N   . LEU D 4 184 ? 20.760  -38.237 1.097   1.00 38.55  ? 178 LEU H N   1 
ATOM   6145 C CA  . LEU D 4 184 ? 21.994  -37.519 1.370   1.00 32.25  ? 178 LEU H CA  1 
ATOM   6146 C C   . LEU D 4 184 ? 23.173  -38.385 0.952   1.00 39.32  ? 178 LEU H C   1 
ATOM   6147 O O   . LEU D 4 184 ? 23.091  -39.615 0.959   1.00 43.08  ? 178 LEU H O   1 
ATOM   6148 C CB  . LEU D 4 184 ? 22.085  -37.144 2.854   1.00 33.51  ? 178 LEU H CB  1 
ATOM   6149 C CG  . LEU D 4 184 ? 23.265  -36.331 3.375   1.00 23.96  ? 178 LEU H CG  1 
ATOM   6150 C CD1 . LEU D 4 184 ? 22.788  -35.469 4.523   1.00 36.09  ? 178 LEU H CD1 1 
ATOM   6151 C CD2 . LEU D 4 184 ? 24.379  -37.251 3.839   1.00 32.00  ? 178 LEU H CD2 1 
ATOM   6152 N N   . SER D 4 185 ? 24.267  -37.729 0.576   1.00 44.41  ? 179 SER H N   1 
ATOM   6153 C CA  . SER D 4 185 ? 25.500  -38.420 0.231   1.00 28.37  ? 179 SER H CA  1 
ATOM   6154 C C   . SER D 4 185 ? 26.666  -37.704 0.885   1.00 34.69  ? 179 SER H C   1 
ATOM   6155 O O   . SER D 4 185 ? 26.689  -36.473 0.952   1.00 42.19  ? 179 SER H O   1 
ATOM   6156 C CB  . SER D 4 185 ? 25.720  -38.478 -1.283  1.00 30.39  ? 179 SER H CB  1 
ATOM   6157 O OG  . SER D 4 185 ? 24.698  -39.222 -1.921  1.00 63.63  ? 179 SER H OG  1 
ATOM   6158 N N   . SER D 4 186 ? 27.629  -38.480 1.365   1.00 33.83  ? 180 SER H N   1 
ATOM   6159 C CA  . SER D 4 186 ? 28.868  -37.942 1.903   1.00 31.88  ? 180 SER H CA  1 
ATOM   6160 C C   . SER D 4 186 ? 30.028  -38.661 1.236   1.00 37.60  ? 180 SER H C   1 
ATOM   6161 O O   . SER D 4 186 ? 30.004  -39.888 1.111   1.00 40.15  ? 180 SER H O   1 
ATOM   6162 C CB  . SER D 4 186 ? 28.930  -38.105 3.422   1.00 33.87  ? 180 SER H CB  1 
ATOM   6163 O OG  . SER D 4 186 ? 30.162  -37.623 3.925   1.00 49.82  ? 180 SER H OG  1 
ATOM   6164 N N   . VAL D 4 187 ? 31.034  -37.899 0.798   1.00 33.36  ? 181 VAL H N   1 
ATOM   6165 C CA  . VAL D 4 187 ? 32.188  -38.450 0.100   1.00 34.79  ? 181 VAL H CA  1 
ATOM   6166 C C   . VAL D 4 187 ? 33.465  -37.954 0.767   1.00 38.13  ? 181 VAL H C   1 
ATOM   6167 O O   . VAL D 4 187 ? 33.467  -36.961 1.498   1.00 39.55  ? 181 VAL H O   1 
ATOM   6168 C CB  . VAL D 4 187 ? 32.195  -38.085 -1.400  1.00 32.05  ? 181 VAL H CB  1 
ATOM   6169 C CG1 . VAL D 4 187 ? 30.878  -38.471 -2.045  1.00 33.42  ? 181 VAL H CG1 1 
ATOM   6170 C CG2 . VAL D 4 187 ? 32.469  -36.603 -1.587  1.00 45.90  ? 181 VAL H CG2 1 
ATOM   6171 N N   . VAL D 4 188 ? 34.561  -38.680 0.520   1.00 34.68  ? 182 VAL H N   1 
ATOM   6172 C CA  . VAL D 4 188 ? 35.872  -38.349 1.069   1.00 36.13  ? 182 VAL H CA  1 
ATOM   6173 C C   . VAL D 4 188 ? 36.932  -38.448 -0.019  1.00 46.18  ? 182 VAL H C   1 
ATOM   6174 O O   . VAL D 4 188 ? 36.820  -39.242 -0.960  1.00 38.34  ? 182 VAL H O   1 
ATOM   6175 C CB  . VAL D 4 188 ? 36.276  -39.267 2.245   1.00 45.29  ? 182 VAL H CB  1 
ATOM   6176 C CG1 . VAL D 4 188 ? 37.345  -38.595 3.103   1.00 42.28  ? 182 VAL H CG1 1 
ATOM   6177 C CG2 . VAL D 4 188 ? 35.078  -39.656 3.073   1.00 48.18  ? 182 VAL H CG2 1 
ATOM   6178 N N   . THR D 4 189 ? 37.991  -37.661 0.144   1.00 46.01  ? 183 THR H N   1 
ATOM   6179 C CA  . THR D 4 189 ? 39.175  -37.728 -0.700  1.00 46.31  ? 183 THR H CA  1 
ATOM   6180 C C   . THR D 4 189 ? 40.319  -38.313 0.118   1.00 51.47  ? 183 THR H C   1 
ATOM   6181 O O   . THR D 4 189 ? 40.684  -37.769 1.166   1.00 54.57  ? 183 THR H O   1 
ATOM   6182 C CB  . THR D 4 189 ? 39.534  -36.345 -1.242  1.00 55.26  ? 183 THR H CB  1 
ATOM   6183 O OG1 . THR D 4 189 ? 38.693  -36.049 -2.364  1.00 43.43  ? 183 THR H OG1 1 
ATOM   6184 C CG2 . THR D 4 189 ? 41.000  -36.280 -1.665  1.00 49.83  ? 183 THR H CG2 1 
ATOM   6185 N N   . VAL D 4 190 ? 40.862  -39.431 -0.352  1.00 42.63  ? 184 VAL H N   1 
ATOM   6186 C CA  . VAL D 4 190 ? 41.957  -40.115 0.332   1.00 43.65  ? 184 VAL H CA  1 
ATOM   6187 C C   . VAL D 4 190 ? 42.998  -40.523 -0.695  1.00 52.07  ? 184 VAL H C   1 
ATOM   6188 O O   . VAL D 4 190 ? 42.698  -40.666 -1.888  1.00 52.72  ? 184 VAL H O   1 
ATOM   6189 C CB  . VAL D 4 190 ? 41.466  -41.352 1.111   1.00 46.95  ? 184 VAL H CB  1 
ATOM   6190 C CG1 . VAL D 4 190 ? 40.502  -40.938 2.211   1.00 36.56  ? 184 VAL H CG1 1 
ATOM   6191 C CG2 . VAL D 4 190 ? 40.807  -42.341 0.169   1.00 49.94  ? 184 VAL H CG2 1 
ATOM   6192 N N   . PRO D 4 191 ? 44.249  -40.682 -0.263  1.00 57.95  ? 185 PRO H N   1 
ATOM   6193 C CA  . PRO D 4 191 ? 45.281  -41.177 -1.181  1.00 55.23  ? 185 PRO H CA  1 
ATOM   6194 C C   . PRO D 4 191 ? 44.925  -42.556 -1.712  1.00 61.11  ? 185 PRO H C   1 
ATOM   6195 O O   . PRO D 4 191 ? 44.414  -43.410 -0.985  1.00 57.17  ? 185 PRO H O   1 
ATOM   6196 C CB  . PRO D 4 191 ? 46.540  -41.216 -0.310  1.00 63.38  ? 185 PRO H CB  1 
ATOM   6197 C CG  . PRO D 4 191 ? 46.282  -40.224 0.768   1.00 52.40  ? 185 PRO H CG  1 
ATOM   6198 C CD  . PRO D 4 191 ? 44.811  -40.292 1.041   1.00 50.63  ? 185 PRO H CD  1 
ATOM   6199 N N   . SER D 4 192 ? 45.209  -42.769 -2.997  1.00 66.98  ? 186 SER H N   1 
ATOM   6200 C CA  . SER D 4 192 ? 44.878  -44.037 -3.633  1.00 56.40  ? 186 SER H CA  1 
ATOM   6201 C C   . SER D 4 192 ? 45.758  -45.184 -3.154  1.00 66.83  ? 186 SER H C   1 
ATOM   6202 O O   . SER D 4 192 ? 45.451  -46.342 -3.455  1.00 82.07  ? 186 SER H O   1 
ATOM   6203 C CB  . SER D 4 192 ? 44.976  -43.900 -5.154  1.00 60.68  ? 186 SER H CB  1 
ATOM   6204 O OG  . SER D 4 192 ? 46.279  -43.514 -5.551  1.00 82.73  ? 186 SER H OG  1 
ATOM   6205 N N   . SER D 4 193 ? 46.835  -44.896 -2.424  1.00 65.41  ? 187 SER H N   1 
ATOM   6206 C CA  . SER D 4 193 ? 47.726  -45.929 -1.918  1.00 65.55  ? 187 SER H CA  1 
ATOM   6207 C C   . SER D 4 193 ? 47.289  -46.489 -0.571  1.00 66.06  ? 187 SER H C   1 
ATOM   6208 O O   . SER D 4 193 ? 47.882  -47.466 -0.102  1.00 62.68  ? 187 SER H O   1 
ATOM   6209 C CB  . SER D 4 193 ? 49.149  -45.380 -1.800  1.00 53.99  ? 187 SER H CB  1 
ATOM   6210 O OG  . SER D 4 193 ? 49.181  -44.250 -0.946  1.00 54.84  ? 187 SER H OG  1 
ATOM   6211 N N   . SER D 4 194 ? 46.274  -45.900 0.056   1.00 66.45  ? 188 SER H N   1 
ATOM   6212 C CA  . SER D 4 194 ? 45.770  -46.357 1.343   1.00 63.02  ? 188 SER H CA  1 
ATOM   6213 C C   . SER D 4 194 ? 44.551  -47.257 1.206   1.00 67.86  ? 188 SER H C   1 
ATOM   6214 O O   . SER D 4 194 ? 43.932  -47.601 2.217   1.00 73.39  ? 188 SER H O   1 
ATOM   6215 C CB  . SER D 4 194 ? 45.433  -45.156 2.225   1.00 60.47  ? 188 SER H CB  1 
ATOM   6216 O OG  . SER D 4 194 ? 46.538  -44.275 2.307   1.00 78.77  ? 188 SER H OG  1 
ATOM   6217 N N   . LEU D 4 195 ? 44.188  -47.635 -0.020  1.00 66.93  ? 189 LEU H N   1 
ATOM   6218 C CA  . LEU D 4 195 ? 42.964  -48.402 -0.231  1.00 69.25  ? 189 LEU H CA  1 
ATOM   6219 C C   . LEU D 4 195 ? 43.055  -49.782 0.410   1.00 76.21  ? 189 LEU H C   1 
ATOM   6220 O O   . LEU D 4 195 ? 42.109  -50.238 1.063   1.00 71.42  ? 189 LEU H O   1 
ATOM   6221 C CB  . LEU D 4 195 ? 42.672  -48.515 -1.729  1.00 73.41  ? 189 LEU H CB  1 
ATOM   6222 C CG  . LEU D 4 195 ? 41.838  -47.408 -2.383  1.00 61.58  ? 189 LEU H CG  1 
ATOM   6223 C CD1 . LEU D 4 195 ? 40.370  -47.596 -2.061  1.00 70.70  ? 189 LEU H CD1 1 
ATOM   6224 C CD2 . LEU D 4 195 ? 42.293  -46.027 -1.949  1.00 54.99  ? 189 LEU H CD2 1 
ATOM   6225 N N   . GLY D 4 196 ? 44.185  -50.465 0.232   1.00 74.56  ? 190 GLY H N   1 
ATOM   6226 C CA  . GLY D 4 196 ? 44.356  -51.782 0.816   1.00 83.52  ? 190 GLY H CA  1 
ATOM   6227 C C   . GLY D 4 196 ? 44.848  -51.793 2.245   1.00 76.59  ? 190 GLY H C   1 
ATOM   6228 O O   . GLY D 4 196 ? 44.806  -52.843 2.894   1.00 62.81  ? 190 GLY H O   1 
ATOM   6229 N N   . THR D 4 197 ? 45.315  -50.650 2.750   1.00 81.35  ? 191 THR H N   1 
ATOM   6230 C CA  . THR D 4 197 ? 45.829  -50.539 4.112   1.00 78.99  ? 191 THR H CA  1 
ATOM   6231 C C   . THR D 4 197 ? 44.800  -49.936 5.062   1.00 80.67  ? 191 THR H C   1 
ATOM   6232 O O   . THR D 4 197 ? 44.468  -50.534 6.090   1.00 70.55  ? 191 THR H O   1 
ATOM   6233 C CB  . THR D 4 197 ? 47.116  -49.701 4.119   1.00 74.20  ? 191 THR H CB  1 
ATOM   6234 O OG1 . THR D 4 197 ? 48.214  -50.502 3.663   1.00 78.73  ? 191 THR H OG1 1 
ATOM   6235 C CG2 . THR D 4 197 ? 47.413  -49.176 5.518   1.00 63.44  ? 191 THR H CG2 1 
ATOM   6236 N N   . GLN D 4 198 ? 44.289  -48.754 4.731   1.00 81.62  ? 192 GLN H N   1 
ATOM   6237 C CA  . GLN D 4 198 ? 43.320  -48.073 5.575   1.00 63.48  ? 192 GLN H CA  1 
ATOM   6238 C C   . GLN D 4 198 ? 41.931  -48.673 5.400   1.00 68.96  ? 192 GLN H C   1 
ATOM   6239 O O   . GLN D 4 198 ? 41.548  -49.088 4.302   1.00 70.76  ? 192 GLN H O   1 
ATOM   6240 C CB  . GLN D 4 198 ? 43.292  -46.579 5.244   1.00 67.94  ? 192 GLN H CB  1 
ATOM   6241 C CG  . GLN D 4 198 ? 44.054  -45.699 6.220   1.00 56.39  ? 192 GLN H CG  1 
ATOM   6242 C CD  . GLN D 4 198 ? 43.281  -45.463 7.501   1.00 74.67  ? 192 GLN H CD  1 
ATOM   6243 O OE1 . GLN D 4 198 ? 42.172  -45.971 7.671   1.00 72.10  ? 192 GLN H OE1 1 
ATOM   6244 N NE2 . GLN D 4 198 ? 43.859  -44.686 8.410   1.00 62.07  ? 192 GLN H NE2 1 
ATOM   6245 N N   . THR D 4 199 ? 41.178  -48.722 6.496   1.00 64.42  ? 193 THR H N   1 
ATOM   6246 C CA  . THR D 4 199 ? 39.775  -49.113 6.479   1.00 57.30  ? 193 THR H CA  1 
ATOM   6247 C C   . THR D 4 199 ? 38.946  -47.864 6.745   1.00 57.42  ? 193 THR H C   1 
ATOM   6248 O O   . THR D 4 199 ? 39.137  -47.198 7.768   1.00 60.29  ? 193 THR H O   1 
ATOM   6249 C CB  . THR D 4 199 ? 39.479  -50.193 7.522   1.00 57.38  ? 193 THR H CB  1 
ATOM   6250 O OG1 . THR D 4 199 ? 39.260  -49.582 8.799   1.00 81.97  ? 193 THR H OG1 1 
ATOM   6251 C CG2 . THR D 4 199 ? 40.649  -51.167 7.634   1.00 54.36  ? 193 THR H CG2 1 
ATOM   6252 N N   . TYR D 4 200 ? 38.044  -47.538 5.824   1.00 64.20  ? 194 TYR H N   1 
ATOM   6253 C CA  . TYR D 4 200 ? 37.237  -46.327 5.910   1.00 49.53  ? 194 TYR H CA  1 
ATOM   6254 C C   . TYR D 4 200 ? 35.798  -46.710 6.225   1.00 43.51  ? 194 TYR H C   1 
ATOM   6255 O O   . TYR D 4 200 ? 35.187  -47.500 5.497   1.00 45.58  ? 194 TYR H O   1 
ATOM   6256 C CB  . TYR D 4 200 ? 37.314  -45.526 4.610   1.00 46.27  ? 194 TYR H CB  1 
ATOM   6257 C CG  . TYR D 4 200 ? 38.707  -45.043 4.270   1.00 49.26  ? 194 TYR H CG  1 
ATOM   6258 C CD1 . TYR D 4 200 ? 39.248  -43.927 4.897   1.00 55.54  ? 194 TYR H CD1 1 
ATOM   6259 C CD2 . TYR D 4 200 ? 39.482  -45.700 3.322   1.00 49.57  ? 194 TYR H CD2 1 
ATOM   6260 C CE1 . TYR D 4 200 ? 40.522  -43.481 4.593   1.00 51.17  ? 194 TYR H CE1 1 
ATOM   6261 C CE2 . TYR D 4 200 ? 40.760  -45.258 3.009   1.00 60.18  ? 194 TYR H CE2 1 
ATOM   6262 C CZ  . TYR D 4 200 ? 41.273  -44.147 3.648   1.00 53.51  ? 194 TYR H CZ  1 
ATOM   6263 O OH  . TYR D 4 200 ? 42.541  -43.699 3.345   1.00 47.68  ? 194 TYR H OH  1 
ATOM   6264 N N   . ILE D 4 201 ? 35.264  -46.156 7.310   1.00 41.35  ? 195 ILE H N   1 
ATOM   6265 C CA  . ILE D 4 201 ? 33.917  -46.463 7.776   1.00 43.80  ? 195 ILE H CA  1 
ATOM   6266 C C   . ILE D 4 201 ? 33.167  -45.151 7.960   1.00 50.01  ? 195 ILE H C   1 
ATOM   6267 O O   . ILE D 4 201 ? 33.704  -44.200 8.539   1.00 45.14  ? 195 ILE H O   1 
ATOM   6268 C CB  . ILE D 4 201 ? 33.937  -47.265 9.092   1.00 44.74  ? 195 ILE H CB  1 
ATOM   6269 C CG1 . ILE D 4 201 ? 34.986  -48.375 9.036   1.00 43.76  ? 195 ILE H CG1 1 
ATOM   6270 C CG2 . ILE D 4 201 ? 32.573  -47.869 9.370   1.00 54.52  ? 195 ILE H CG2 1 
ATOM   6271 C CD1 . ILE D 4 201 ? 35.013  -49.239 10.276  1.00 38.05  ? 195 ILE H CD1 1 
ATOM   6272 N N   . CYS D 4 202 ? 31.933  -45.094 7.467   1.00 46.12  ? 196 CYS H N   1 
ATOM   6273 C CA  . CYS D 4 202 ? 31.089  -43.918 7.626   1.00 53.88  ? 196 CYS H CA  1 
ATOM   6274 C C   . CYS D 4 202 ? 30.070  -44.176 8.728   1.00 53.30  ? 196 CYS H C   1 
ATOM   6275 O O   . CYS D 4 202 ? 29.454  -45.246 8.777   1.00 47.92  ? 196 CYS H O   1 
ATOM   6276 C CB  . CYS D 4 202 ? 30.387  -43.551 6.316   1.00 44.34  ? 196 CYS H CB  1 
ATOM   6277 S SG  . CYS D 4 202 ? 29.133  -44.723 5.761   1.00 66.51  ? 196 CYS H SG  1 
ATOM   6278 N N   . ASN D 4 203 ? 29.915  -43.205 9.620   1.00 47.74  ? 197 ASN H N   1 
ATOM   6279 C CA  . ASN D 4 203 ? 29.044  -43.325 10.781  1.00 40.22  ? 197 ASN H CA  1 
ATOM   6280 C C   . ASN D 4 203 ? 27.817  -42.463 10.540  1.00 44.87  ? 197 ASN H C   1 
ATOM   6281 O O   . ASN D 4 203 ? 27.916  -41.232 10.490  1.00 47.68  ? 197 ASN H O   1 
ATOM   6282 C CB  . ASN D 4 203 ? 29.779  -42.899 12.047  1.00 44.68  ? 197 ASN H CB  1 
ATOM   6283 C CG  . ASN D 4 203 ? 31.179  -43.453 12.109  1.00 50.51  ? 197 ASN H CG  1 
ATOM   6284 O OD1 . ASN D 4 203 ? 32.152  -42.730 11.910  1.00 53.30  ? 197 ASN H OD1 1 
ATOM   6285 N ND2 . ASN D 4 203 ? 31.290  -44.750 12.370  1.00 54.87  ? 197 ASN H ND2 1 
ATOM   6286 N N   . VAL D 4 204 ? 26.663  -43.106 10.397  1.00 40.85  ? 198 VAL H N   1 
ATOM   6287 C CA  . VAL D 4 204 ? 25.404  -42.424 10.126  1.00 41.16  ? 198 VAL H CA  1 
ATOM   6288 C C   . VAL D 4 204 ? 24.539  -42.524 11.373  1.00 46.26  ? 198 VAL H C   1 
ATOM   6289 O O   . VAL D 4 204 ? 24.293  -43.626 11.880  1.00 52.17  ? 198 VAL H O   1 
ATOM   6290 C CB  . VAL D 4 204 ? 24.686  -43.023 8.909   1.00 44.62  ? 198 VAL H CB  1 
ATOM   6291 C CG1 . VAL D 4 204 ? 23.426  -42.232 8.603   1.00 43.47  ? 198 VAL H CG1 1 
ATOM   6292 C CG2 . VAL D 4 204 ? 25.619  -43.063 7.705   1.00 44.96  ? 198 VAL H CG2 1 
ATOM   6293 N N   . ASN D 4 205 ? 24.081  -41.378 11.868  1.00 38.91  ? 199 ASN H N   1 
ATOM   6294 C CA  . ASN D 4 205 ? 23.252  -41.316 13.063  1.00 37.39  ? 199 ASN H CA  1 
ATOM   6295 C C   . ASN D 4 205 ? 21.995  -40.519 12.751  1.00 41.18  ? 199 ASN H C   1 
ATOM   6296 O O   . ASN D 4 205 ? 22.079  -39.383 12.273  1.00 47.91  ? 199 ASN H O   1 
ATOM   6297 C CB  . ASN D 4 205 ? 24.017  -40.685 14.232  1.00 42.31  ? 199 ASN H CB  1 
ATOM   6298 C CG  . ASN D 4 205 ? 23.255  -40.758 15.541  1.00 50.62  ? 199 ASN H CG  1 
ATOM   6299 O OD1 . ASN D 4 205 ? 22.488  -41.693 15.778  1.00 62.68  ? 199 ASN H OD1 1 
ATOM   6300 N ND2 . ASN D 4 205 ? 23.465  -39.769 16.400  1.00 53.86  ? 199 ASN H ND2 1 
ATOM   6301 N N   . HIS D 4 206 ? 20.836  -41.116 13.018  1.00 35.19  ? 200 HIS H N   1 
ATOM   6302 C CA  . HIS D 4 206 ? 19.539  -40.483 12.780  1.00 50.67  ? 200 HIS H CA  1 
ATOM   6303 C C   . HIS D 4 206 ? 18.760  -40.553 14.091  1.00 49.19  ? 200 HIS H C   1 
ATOM   6304 O O   . HIS D 4 206 ? 18.039  -41.524 14.333  1.00 43.70  ? 200 HIS H O   1 
ATOM   6305 C CB  . HIS D 4 206 ? 18.794  -41.166 11.638  1.00 43.95  ? 200 HIS H CB  1 
ATOM   6306 C CG  . HIS D 4 206 ? 17.523  -40.479 11.256  1.00 37.11  ? 200 HIS H CG  1 
ATOM   6307 N ND1 . HIS D 4 206 ? 16.458  -41.143 10.688  1.00 51.34  ? 200 HIS H ND1 1 
ATOM   6308 C CD2 . HIS D 4 206 ? 17.147  -39.183 11.356  1.00 45.49  ? 200 HIS H CD2 1 
ATOM   6309 C CE1 . HIS D 4 206 ? 15.478  -40.287 10.460  1.00 46.18  ? 200 HIS H CE1 1 
ATOM   6310 N NE2 . HIS D 4 206 ? 15.871  -39.090 10.856  1.00 48.62  ? 200 HIS H NE2 1 
ATOM   6311 N N   . LYS D 4 207 ? 18.914  -39.528 14.932  1.00 52.54  ? 201 LYS H N   1 
ATOM   6312 C CA  . LYS D 4 207 ? 18.261  -39.544 16.239  1.00 49.11  ? 201 LYS H CA  1 
ATOM   6313 C C   . LYS D 4 207 ? 16.741  -39.671 16.168  1.00 48.96  ? 201 LYS H C   1 
ATOM   6314 O O   . LYS D 4 207 ? 16.182  -40.430 16.980  1.00 40.31  ? 201 LYS H O   1 
ATOM   6315 C CB  . LYS D 4 207 ? 18.661  -38.301 17.050  1.00 47.65  ? 201 LYS H CB  1 
ATOM   6316 C CG  . LYS D 4 207 ? 17.834  -38.131 18.331  1.00 71.27  ? 201 LYS H CG  1 
ATOM   6317 C CD  . LYS D 4 207 ? 18.554  -37.324 19.408  1.00 65.30  ? 201 LYS H CD  1 
ATOM   6318 C CE  . LYS D 4 207 ? 17.920  -37.541 20.787  1.00 78.93  ? 201 LYS H CE  1 
ATOM   6319 N NZ  . LYS D 4 207 ? 18.564  -38.650 21.562  1.00 59.01  ? 201 LYS H NZ  1 
ATOM   6320 N N   . PRO D 4 208 ? 16.020  -38.976 15.274  1.00 43.65  ? 202 PRO H N   1 
ATOM   6321 C CA  . PRO D 4 208 ? 14.558  -39.161 15.235  1.00 35.47  ? 202 PRO H CA  1 
ATOM   6322 C C   . PRO D 4 208 ? 14.139  -40.608 15.046  1.00 40.36  ? 202 PRO H C   1 
ATOM   6323 O O   . PRO D 4 208 ? 13.140  -41.045 15.630  1.00 52.38  ? 202 PRO H O   1 
ATOM   6324 C CB  . PRO D 4 208 ? 14.133  -38.285 14.051  1.00 45.24  ? 202 PRO H CB  1 
ATOM   6325 C CG  . PRO D 4 208 ? 15.159  -37.218 14.004  1.00 43.29  ? 202 PRO H CG  1 
ATOM   6326 C CD  . PRO D 4 208 ? 16.446  -37.893 14.367  1.00 32.15  ? 202 PRO H CD  1 
ATOM   6327 N N   . SER D 4 209 ? 14.878  -41.365 14.245  1.00 58.64  ? 203 SER H N   1 
ATOM   6328 C CA  . SER D 4 209 ? 14.635  -42.790 14.081  1.00 49.83  ? 203 SER H CA  1 
ATOM   6329 C C   . SER D 4 209 ? 15.457  -43.645 15.037  1.00 54.30  ? 203 SER H C   1 
ATOM   6330 O O   . SER D 4 209 ? 15.271  -44.866 15.065  1.00 58.27  ? 203 SER H O   1 
ATOM   6331 C CB  . SER D 4 209 ? 14.928  -43.204 12.635  1.00 56.21  ? 203 SER H CB  1 
ATOM   6332 O OG  . SER D 4 209 ? 14.805  -44.604 12.468  1.00 71.76  ? 203 SER H OG  1 
ATOM   6333 N N   . ASN D 4 210 ? 16.349  -43.035 15.819  1.00 62.59  ? 204 ASN H N   1 
ATOM   6334 C CA  . ASN D 4 210 ? 17.236  -43.763 16.729  1.00 54.72  ? 204 ASN H CA  1 
ATOM   6335 C C   . ASN D 4 210 ? 18.028  -44.836 15.983  1.00 52.23  ? 204 ASN H C   1 
ATOM   6336 O O   . ASN D 4 210 ? 18.189  -45.964 16.453  1.00 48.89  ? 204 ASN H O   1 
ATOM   6337 C CB  . ASN D 4 210 ? 16.452  -44.367 17.894  1.00 51.14  ? 204 ASN H CB  1 
ATOM   6338 C CG  . ASN D 4 210 ? 17.182  -44.231 19.209  1.00 64.39  ? 204 ASN H CG  1 
ATOM   6339 O OD1 . ASN D 4 210 ? 17.177  -43.165 19.825  1.00 81.95  ? 204 ASN H OD1 1 
ATOM   6340 N ND2 . ASN D 4 210 ? 17.818  -45.309 19.649  1.00 63.87  ? 204 ASN H ND2 1 
ATOM   6341 N N   . THR D 4 211 ? 18.530  -44.473 14.807  1.00 54.82  ? 205 THR H N   1 
ATOM   6342 C CA  . THR D 4 211 ? 19.259  -45.379 13.930  1.00 44.80  ? 205 THR H CA  1 
ATOM   6343 C C   . THR D 4 211 ? 20.743  -45.043 13.966  1.00 53.32  ? 205 THR H C   1 
ATOM   6344 O O   . THR D 4 211 ? 21.123  -43.880 13.797  1.00 57.85  ? 205 THR H O   1 
ATOM   6345 C CB  . THR D 4 211 ? 18.744  -45.281 12.493  1.00 51.74  ? 205 THR H CB  1 
ATOM   6346 O OG1 . THR D 4 211 ? 17.341  -45.563 12.462  1.00 57.02  ? 205 THR H OG1 1 
ATOM   6347 C CG2 . THR D 4 211 ? 19.479  -46.265 11.593  1.00 50.08  ? 205 THR H CG2 1 
ATOM   6348 N N   . LYS D 4 212 ? 21.575  -46.059 14.184  1.00 47.93  ? 206 LYS H N   1 
ATOM   6349 C CA  . LYS D 4 212 ? 23.024  -45.909 14.135  1.00 40.12  ? 206 LYS H CA  1 
ATOM   6350 C C   . LYS D 4 212 ? 23.591  -46.998 13.239  1.00 49.14  ? 206 LYS H C   1 
ATOM   6351 O O   . LYS D 4 212 ? 23.478  -48.186 13.558  1.00 65.72  ? 206 LYS H O   1 
ATOM   6352 C CB  . LYS D 4 212 ? 23.642  -45.976 15.535  1.00 36.37  ? 206 LYS H CB  1 
ATOM   6353 C CG  . LYS D 4 212 ? 23.381  -44.740 16.389  1.00 59.64  ? 206 LYS H CG  1 
ATOM   6354 C CD  . LYS D 4 212 ? 24.175  -44.766 17.691  1.00 78.96  ? 206 LYS H CD  1 
ATOM   6355 C CE  . LYS D 4 212 ? 23.629  -45.795 18.672  1.00 66.12  ? 206 LYS H CE  1 
ATOM   6356 N NZ  . LYS D 4 212 ? 24.324  -45.733 19.990  1.00 65.19  ? 206 LYS H NZ  1 
ATOM   6357 N N   . VAL D 4 213 ? 24.193  -46.594 12.123  1.00 43.55  ? 207 VAL H N   1 
ATOM   6358 C CA  . VAL D 4 213 ? 24.761  -47.511 11.143  1.00 46.44  ? 207 VAL H CA  1 
ATOM   6359 C C   . VAL D 4 213 ? 26.219  -47.143 10.913  1.00 52.61  ? 207 VAL H C   1 
ATOM   6360 O O   . VAL D 4 213 ? 26.532  -45.985 10.614  1.00 57.66  ? 207 VAL H O   1 
ATOM   6361 C CB  . VAL D 4 213 ? 23.978  -47.481 9.816   1.00 34.61  ? 207 VAL H CB  1 
ATOM   6362 C CG1 . VAL D 4 213 ? 24.736  -48.234 8.734   1.00 52.40  ? 207 VAL H CG1 1 
ATOM   6363 C CG2 . VAL D 4 213 ? 22.599  -48.075 10.011  1.00 48.23  ? 207 VAL H CG2 1 
ATOM   6364 N N   . ASP D 4 214 ? 27.103  -48.130 11.050  1.00 60.08  ? 208 ASP H N   1 
ATOM   6365 C CA  . ASP D 4 214 ? 28.528  -47.991 10.757  1.00 61.62  ? 208 ASP H CA  1 
ATOM   6366 C C   . ASP D 4 214 ? 28.810  -48.816 9.505   1.00 63.90  ? 208 ASP H C   1 
ATOM   6367 O O   . ASP D 4 214 ? 28.968  -50.038 9.579   1.00 80.31  ? 208 ASP H O   1 
ATOM   6368 C CB  . ASP D 4 214 ? 29.384  -48.449 11.938  1.00 68.68  ? 208 ASP H CB  1 
ATOM   6369 C CG  . ASP D 4 214 ? 29.206  -47.574 13.170  1.00 78.57  ? 208 ASP H CG  1 
ATOM   6370 O OD1 . ASP D 4 214 ? 28.871  -46.382 13.012  1.00 69.17  ? 208 ASP H OD1 1 
ATOM   6371 O OD2 . ASP D 4 214 ? 29.410  -48.077 14.297  1.00 82.59  ? 208 ASP H OD2 1 
ATOM   6372 N N   . LYS D 4 215 ? 28.866  -48.148 8.356   1.00 66.39  ? 209 LYS H N   1 
ATOM   6373 C CA  . LYS D 4 215 ? 29.061  -48.804 7.069   1.00 66.87  ? 209 LYS H CA  1 
ATOM   6374 C C   . LYS D 4 215 ? 30.516  -48.659 6.642   1.00 63.61  ? 209 LYS H C   1 
ATOM   6375 O O   . LYS D 4 215 ? 31.010  -47.538 6.483   1.00 66.34  ? 209 LYS H O   1 
ATOM   6376 C CB  . LYS D 4 215 ? 28.136  -48.205 6.011   1.00 54.84  ? 209 LYS H CB  1 
ATOM   6377 C CG  . LYS D 4 215 ? 28.325  -48.785 4.620   1.00 45.57  ? 209 LYS H CG  1 
ATOM   6378 C CD  . LYS D 4 215 ? 27.648  -50.134 4.499   1.00 45.91  ? 209 LYS H CD  1 
ATOM   6379 C CE  . LYS D 4 215 ? 26.196  -50.034 4.928   1.00 61.48  ? 209 LYS H CE  1 
ATOM   6380 N NZ  . LYS D 4 215 ? 25.376  -51.162 4.416   1.00 64.79  ? 209 LYS H NZ  1 
ATOM   6381 N N   . LYS D 4 216 ? 31.196  -49.787 6.455   1.00 49.18  ? 210 LYS H N   1 
ATOM   6382 C CA  . LYS D 4 216 ? 32.574  -49.782 5.986   1.00 51.10  ? 210 LYS H CA  1 
ATOM   6383 C C   . LYS D 4 216 ? 32.591  -49.881 4.467   1.00 45.44  ? 210 LYS H C   1 
ATOM   6384 O O   . LYS D 4 216 ? 31.866  -50.695 3.885   1.00 48.21  ? 210 LYS H O   1 
ATOM   6385 C CB  . LYS D 4 216 ? 33.366  -50.937 6.600   1.00 55.04  ? 210 LYS H CB  1 
ATOM   6386 C CG  . LYS D 4 216 ? 34.859  -50.857 6.320   1.00 72.28  ? 210 LYS H CG  1 
ATOM   6387 C CD  . LYS D 4 216 ? 35.510  -52.230 6.290   1.00 69.25  ? 210 LYS H CD  1 
ATOM   6388 C CE  . LYS D 4 216 ? 36.922  -52.140 5.719   1.00 70.80  ? 210 LYS H CE  1 
ATOM   6389 N NZ  . LYS D 4 216 ? 37.098  -50.912 4.883   1.00 66.90  ? 210 LYS H NZ  1 
ATOM   6390 N N   . VAL D 4 217 ? 33.411  -49.052 3.828   1.00 38.20  ? 211 VAL H N   1 
ATOM   6391 C CA  . VAL D 4 217 ? 33.538  -49.057 2.377   1.00 41.96  ? 211 VAL H CA  1 
ATOM   6392 C C   . VAL D 4 217 ? 34.920  -49.577 2.010   1.00 48.79  ? 211 VAL H C   1 
ATOM   6393 O O   . VAL D 4 217 ? 35.904  -49.365 2.729   1.00 57.47  ? 211 VAL H O   1 
ATOM   6394 C CB  . VAL D 4 217 ? 33.290  -47.662 1.760   1.00 47.82  ? 211 VAL H CB  1 
ATOM   6395 C CG1 . VAL D 4 217 ? 32.081  -47.006 2.400   1.00 44.80  ? 211 VAL H CG1 1 
ATOM   6396 C CG2 . VAL D 4 217 ? 34.516  -46.778 1.891   1.00 54.86  ? 211 VAL H CG2 1 
ATOM   6397 N N   . GLU D 4 218 ? 34.982  -50.283 0.887   1.00 52.46  ? 212 GLU H N   1 
ATOM   6398 C CA  . GLU D 4 218 ? 36.222  -50.869 0.403   1.00 52.24  ? 212 GLU H CA  1 
ATOM   6399 C C   . GLU D 4 218 ? 36.069  -51.141 -1.084  1.00 58.94  ? 212 GLU H C   1 
ATOM   6400 O O   . GLU D 4 218 ? 34.943  -51.261 -1.582  1.00 66.92  ? 212 GLU H O   1 
ATOM   6401 C CB  . GLU D 4 218 ? 36.560  -52.160 1.166   1.00 53.16  ? 212 GLU H CB  1 
ATOM   6402 C CG  . GLU D 4 218 ? 35.362  -53.045 1.450   1.00 62.75  ? 212 GLU H CG  1 
ATOM   6403 C CD  . GLU D 4 218 ? 35.753  -54.347 2.116   1.00 84.07  ? 212 GLU H CD  1 
ATOM   6404 O OE1 . GLU D 4 218 ? 35.759  -55.389 1.428   1.00 88.08  ? 212 GLU H OE1 1 
ATOM   6405 O OE2 . GLU D 4 218 ? 36.059  -54.325 3.328   1.00 79.44  ? 212 GLU H OE2 1 
ATOM   6406 N N   . PRO D 4 219 ? 37.175  -51.224 -1.823  1.00 57.56  ? 213 PRO H N   1 
ATOM   6407 C CA  . PRO D 4 219 ? 37.075  -51.473 -3.266  1.00 61.83  ? 213 PRO H CA  1 
ATOM   6408 C C   . PRO D 4 219 ? 36.430  -52.820 -3.561  1.00 64.71  ? 213 PRO H C   1 
ATOM   6409 O O   . PRO D 4 219 ? 36.584  -53.787 -2.813  1.00 79.52  ? 213 PRO H O   1 
ATOM   6410 C CB  . PRO D 4 219 ? 38.534  -51.432 -3.739  1.00 66.86  ? 213 PRO H CB  1 
ATOM   6411 C CG  . PRO D 4 219 ? 39.352  -51.654 -2.499  1.00 61.34  ? 213 PRO H CG  1 
ATOM   6412 C CD  . PRO D 4 219 ? 38.570  -51.032 -1.388  1.00 42.43  ? 213 PRO H CD  1 
ATOM   6413 N N   . LYS D 4 220 ? 35.695  -52.872 -4.669  1.00 67.05  ? 214 LYS H N   1 
ATOM   6414 C CA  . LYS D 4 220 ? 34.975  -54.084 -5.053  1.00 81.27  ? 214 LYS H CA  1 
ATOM   6415 C C   . LYS D 4 220 ? 35.731  -54.907 -6.095  1.00 71.28  ? 214 LYS H C   1 
ATOM   6416 O O   . LYS D 4 220 ? 36.943  -54.765 -6.259  1.00 71.10  ? 214 LYS H O   1 
ATOM   6417 C CB  . LYS D 4 220 ? 33.591  -53.723 -5.587  1.00 78.92  ? 214 LYS H CB  1 
ATOM   6418 C CG  . LYS D 4 220 ? 33.631  -52.782 -6.778  1.00 66.58  ? 214 LYS H CG  1 
ATOM   6419 C CD  . LYS D 4 220 ? 32.277  -52.134 -7.020  1.00 73.88  ? 214 LYS H CD  1 
ATOM   6420 C CE  . LYS D 4 220 ? 31.170  -53.170 -7.148  1.00 72.33  ? 214 LYS H CE  1 
ATOM   6421 N NZ  . LYS D 4 220 ? 29.827  -52.531 -7.268  1.00 68.61  ? 214 LYS H NZ  1 
ATOM   6422 N N   . ASP E 5 1   ? 3.442   -0.917  2.780   1.00 78.35  ? 1   ASP L N   1 
ATOM   6423 C CA  . ASP E 5 1   ? 4.271   -1.979  2.223   1.00 57.76  ? 1   ASP L CA  1 
ATOM   6424 C C   . ASP E 5 1   ? 5.383   -1.418  1.347   1.00 66.46  ? 1   ASP L C   1 
ATOM   6425 O O   . ASP E 5 1   ? 5.235   -1.324  0.130   1.00 74.67  ? 1   ASP L O   1 
ATOM   6426 C CB  . ASP E 5 1   ? 3.419   -2.955  1.414   1.00 65.73  ? 1   ASP L CB  1 
ATOM   6427 C CG  . ASP E 5 1   ? 2.423   -3.705  2.271   1.00 90.75  ? 1   ASP L CG  1 
ATOM   6428 O OD1 . ASP E 5 1   ? 2.754   -4.005  3.436   1.00 76.47  ? 1   ASP L OD1 1 
ATOM   6429 O OD2 . ASP E 5 1   ? 1.311   -3.991  1.781   1.00 108.93 ? 1   ASP L OD2 1 
ATOM   6430 N N   . ILE E 5 2   ? 6.495   -1.047  1.972   1.00 61.47  ? 2   ILE L N   1 
ATOM   6431 C CA  . ILE E 5 2   ? 7.651   -0.541  1.241   1.00 51.04  ? 2   ILE L CA  1 
ATOM   6432 C C   . ILE E 5 2   ? 8.391   -1.712  0.610   1.00 62.19  ? 2   ILE L C   1 
ATOM   6433 O O   . ILE E 5 2   ? 8.750   -2.678  1.294   1.00 58.12  ? 2   ILE L O   1 
ATOM   6434 C CB  . ILE E 5 2   ? 8.577   0.257   2.171   1.00 41.23  ? 2   ILE L CB  1 
ATOM   6435 C CG1 . ILE E 5 2   ? 7.809   1.406   2.828   1.00 31.67  ? 2   ILE L CG1 1 
ATOM   6436 C CG2 . ILE E 5 2   ? 9.809   0.750   1.409   1.00 39.48  ? 2   ILE L CG2 1 
ATOM   6437 C CD1 . ILE E 5 2   ? 8.688   2.378   3.578   1.00 51.71  ? 2   ILE L CD1 1 
ATOM   6438 N N   . GLN E 5 3   ? 8.632   -1.624  -0.694  1.00 68.32  ? 3   GLN L N   1 
ATOM   6439 C CA  . GLN E 5 3   ? 9.325   -2.664  -1.442  1.00 50.40  ? 3   GLN L CA  1 
ATOM   6440 C C   . GLN E 5 3   ? 10.807  -2.327  -1.541  1.00 51.84  ? 3   GLN L C   1 
ATOM   6441 O O   . GLN E 5 3   ? 11.170  -1.198  -1.887  1.00 69.33  ? 3   GLN L O   1 
ATOM   6442 C CB  . GLN E 5 3   ? 8.722   -2.817  -2.839  1.00 66.12  ? 3   GLN L CB  1 
ATOM   6443 C CG  . GLN E 5 3   ? 7.381   -3.530  -2.862  1.00 73.89  ? 3   GLN L CG  1 
ATOM   6444 C CD  . GLN E 5 3   ? 7.525   -5.022  -2.656  1.00 96.19  ? 3   GLN L CD  1 
ATOM   6445 O OE1 . GLN E 5 3   ? 8.593   -5.589  -2.890  1.00 100.56 ? 3   GLN L OE1 1 
ATOM   6446 N NE2 . GLN E 5 3   ? 6.452   -5.668  -2.213  1.00 98.09  ? 3   GLN L NE2 1 
ATOM   6447 N N   . LEU E 5 4   ? 11.656  -3.303  -1.227  1.00 56.71  ? 4   LEU L N   1 
ATOM   6448 C CA  . LEU E 5 4   ? 13.104  -3.162  -1.325  1.00 44.74  ? 4   LEU L CA  1 
ATOM   6449 C C   . LEU E 5 4   ? 13.625  -4.187  -2.320  1.00 46.19  ? 4   LEU L C   1 
ATOM   6450 O O   . LEU E 5 4   ? 13.400  -5.390  -2.148  1.00 60.26  ? 4   LEU L O   1 
ATOM   6451 C CB  . LEU E 5 4   ? 13.774  -3.360  0.036   1.00 47.43  ? 4   LEU L CB  1 
ATOM   6452 C CG  . LEU E 5 4   ? 13.479  -2.349  1.141   1.00 45.79  ? 4   LEU L CG  1 
ATOM   6453 C CD1 . LEU E 5 4   ? 13.637  -3.000  2.499   1.00 47.82  ? 4   LEU L CD1 1 
ATOM   6454 C CD2 . LEU E 5 4   ? 14.419  -1.171  1.019   1.00 54.62  ? 4   LEU L CD2 1 
ATOM   6455 N N   . THR E 5 5   ? 14.309  -3.713  -3.358  1.00 53.96  ? 5   THR L N   1 
ATOM   6456 C CA  . THR E 5 5   ? 14.964  -4.575  -4.332  1.00 49.64  ? 5   THR L CA  1 
ATOM   6457 C C   . THR E 5 5   ? 16.449  -4.252  -4.329  1.00 52.65  ? 5   THR L C   1 
ATOM   6458 O O   . THR E 5 5   ? 16.835  -3.092  -4.505  1.00 54.25  ? 5   THR L O   1 
ATOM   6459 C CB  . THR E 5 5   ? 14.385  -4.389  -5.738  1.00 51.97  ? 5   THR L CB  1 
ATOM   6460 O OG1 . THR E 5 5   ? 14.936  -3.205  -6.327  1.00 77.67  ? 5   THR L OG1 1 
ATOM   6461 C CG2 . THR E 5 5   ? 12.865  -4.261  -5.682  1.00 61.21  ? 5   THR L CG2 1 
ATOM   6462 N N   . GLN E 5 6   ? 17.276  -5.269  -4.123  1.00 55.58  ? 6   GLN L N   1 
ATOM   6463 C CA  . GLN E 5 6   ? 18.716  -5.087  -4.063  1.00 53.83  ? 6   GLN L CA  1 
ATOM   6464 C C   . GLN E 5 6   ? 19.373  -5.813  -5.226  1.00 48.92  ? 6   GLN L C   1 
ATOM   6465 O O   . GLN E 5 6   ? 18.919  -6.882  -5.643  1.00 50.68  ? 6   GLN L O   1 
ATOM   6466 C CB  . GLN E 5 6   ? 19.297  -5.572  -2.726  1.00 42.71  ? 6   GLN L CB  1 
ATOM   6467 C CG  . GLN E 5 6   ? 18.797  -6.922  -2.259  1.00 61.26  ? 6   GLN L CG  1 
ATOM   6468 C CD  . GLN E 5 6   ? 19.350  -7.308  -0.896  1.00 59.29  ? 6   GLN L CD  1 
ATOM   6469 O OE1 . GLN E 5 6   ? 18.638  -7.868  -0.062  1.00 61.73  ? 6   GLN L OE1 1 
ATOM   6470 N NE2 . GLN E 5 6   ? 20.625  -7.013  -0.667  1.00 40.40  ? 6   GLN L NE2 1 
ATOM   6471 N N   . SER E 5 7   ? 20.425  -5.210  -5.763  1.00 46.11  ? 7   SER L N   1 
ATOM   6472 C CA  . SER E 5 7   ? 21.143  -5.790  -6.882  1.00 53.91  ? 7   SER L CA  1 
ATOM   6473 C C   . SER E 5 7   ? 22.637  -5.782  -6.597  1.00 53.62  ? 7   SER L C   1 
ATOM   6474 O O   . SER E 5 7   ? 23.128  -4.918  -5.865  1.00 48.82  ? 7   SER L O   1 
ATOM   6475 C CB  . SER E 5 7   ? 20.848  -5.020  -8.180  1.00 56.41  ? 7   SER L CB  1 
ATOM   6476 O OG  . SER E 5 7   ? 21.228  -3.658  -8.076  1.00 61.63  ? 7   SER L OG  1 
ATOM   6477 N N   . PRO E 5 8   ? 23.382  -6.748  -7.145  1.00 49.29  ? 8   PRO L N   1 
ATOM   6478 C CA  . PRO E 5 8   ? 22.897  -7.897  -7.922  1.00 58.09  ? 8   PRO L CA  1 
ATOM   6479 C C   . PRO E 5 8   ? 22.487  -9.056  -7.022  1.00 63.03  ? 8   PRO L C   1 
ATOM   6480 O O   . PRO E 5 8   ? 22.694  -9.020  -5.811  1.00 61.12  ? 8   PRO L O   1 
ATOM   6481 C CB  . PRO E 5 8   ? 24.102  -8.245  -8.800  1.00 54.77  ? 8   PRO L CB  1 
ATOM   6482 C CG  . PRO E 5 8   ? 25.291  -7.922  -7.885  1.00 56.17  ? 8   PRO L CG  1 
ATOM   6483 C CD  . PRO E 5 8   ? 24.859  -6.692  -7.102  1.00 53.59  ? 8   PRO L CD  1 
ATOM   6484 N N   . ASP E 5 9   ? 21.898  -10.103 -7.601  1.00 63.75  ? 9   ASP L N   1 
ATOM   6485 C CA  . ASP E 5 9   ? 21.496  -11.258 -6.805  1.00 56.85  ? 9   ASP L CA  1 
ATOM   6486 C C   . ASP E 5 9   ? 22.703  -11.994 -6.242  1.00 56.22  ? 9   ASP L C   1 
ATOM   6487 O O   . ASP E 5 9   ? 22.680  -12.442 -5.091  1.00 63.14  ? 9   ASP L O   1 
ATOM   6488 C CB  . ASP E 5 9   ? 20.641  -12.194 -7.651  1.00 66.17  ? 9   ASP L CB  1 
ATOM   6489 C CG  . ASP E 5 9   ? 19.449  -11.494 -8.250  1.00 65.45  ? 9   ASP L CG  1 
ATOM   6490 O OD1 . ASP E 5 9   ? 18.859  -10.641 -7.555  1.00 65.42  ? 9   ASP L OD1 1 
ATOM   6491 O OD2 . ASP E 5 9   ? 19.110  -11.784 -9.416  1.00 88.34  ? 9   ASP L OD2 1 
ATOM   6492 N N   . SER E 5 10  ? 23.760  -12.134 -7.037  1.00 58.17  ? 10  SER L N   1 
ATOM   6493 C CA  . SER E 5 10  ? 24.976  -12.808 -6.610  1.00 49.92  ? 10  SER L CA  1 
ATOM   6494 C C   . SER E 5 10  ? 26.177  -11.937 -6.946  1.00 50.41  ? 10  SER L C   1 
ATOM   6495 O O   . SER E 5 10  ? 26.160  -11.177 -7.919  1.00 53.13  ? 10  SER L O   1 
ATOM   6496 C CB  . SER E 5 10  ? 25.116  -14.187 -7.271  1.00 52.96  ? 10  SER L CB  1 
ATOM   6497 O OG  . SER E 5 10  ? 25.119  -14.078 -8.683  1.00 67.22  ? 10  SER L OG  1 
ATOM   6498 N N   . LEU E 5 11  ? 27.220  -12.048 -6.122  1.00 51.37  ? 11  LEU L N   1 
ATOM   6499 C CA  . LEU E 5 11  ? 28.424  -11.238 -6.261  1.00 41.96  ? 11  LEU L CA  1 
ATOM   6500 C C   . LEU E 5 11  ? 29.650  -12.128 -6.117  1.00 51.84  ? 11  LEU L C   1 
ATOM   6501 O O   . LEU E 5 11  ? 29.668  -13.038 -5.283  1.00 64.69  ? 11  LEU L O   1 
ATOM   6502 C CB  . LEU E 5 11  ? 28.468  -10.114 -5.209  1.00 45.23  ? 11  LEU L CB  1 
ATOM   6503 C CG  . LEU E 5 11  ? 29.276  -8.849  -5.518  1.00 43.77  ? 11  LEU L CG  1 
ATOM   6504 C CD1 . LEU E 5 11  ? 28.435  -7.917  -6.373  1.00 60.71  ? 11  LEU L CD1 1 
ATOM   6505 C CD2 . LEU E 5 11  ? 29.708  -8.145  -4.250  1.00 53.93  ? 11  LEU L CD2 1 
ATOM   6506 N N   . ALA E 5 12  ? 30.673  -11.863 -6.929  1.00 56.75  ? 12  ALA L N   1 
ATOM   6507 C CA  . ALA E 5 12  ? 31.943  -12.585 -6.865  1.00 45.72  ? 12  ALA L CA  1 
ATOM   6508 C C   . ALA E 5 12  ? 33.076  -11.574 -6.747  1.00 50.65  ? 12  ALA L C   1 
ATOM   6509 O O   . ALA E 5 12  ? 33.352  -10.833 -7.696  1.00 55.25  ? 12  ALA L O   1 
ATOM   6510 C CB  . ALA E 5 12  ? 32.137  -13.476 -8.090  1.00 42.23  ? 12  ALA L CB  1 
ATOM   6511 N N   . VAL E 5 13  ? 33.734  -11.548 -5.589  1.00 48.88  ? 13  VAL L N   1 
ATOM   6512 C CA  . VAL E 5 13  ? 34.805  -10.601 -5.299  1.00 56.42  ? 13  VAL L CA  1 
ATOM   6513 C C   . VAL E 5 13  ? 36.007  -11.374 -4.774  1.00 59.12  ? 13  VAL L C   1 
ATOM   6514 O O   . VAL E 5 13  ? 35.866  -12.214 -3.878  1.00 56.74  ? 13  VAL L O   1 
ATOM   6515 C CB  . VAL E 5 13  ? 34.358  -9.532  -4.281  1.00 48.49  ? 13  VAL L CB  1 
ATOM   6516 C CG1 . VAL E 5 13  ? 35.537  -8.701  -3.813  1.00 48.28  ? 13  VAL L CG1 1 
ATOM   6517 C CG2 . VAL E 5 13  ? 33.298  -8.636  -4.892  1.00 50.63  ? 13  VAL L CG2 1 
ATOM   6518 N N   . SER E 5 14  ? 37.184  -11.089 -5.327  1.00 58.60  ? 14  SER L N   1 
ATOM   6519 C CA  . SER E 5 14  ? 38.402  -11.749 -4.881  1.00 53.04  ? 14  SER L CA  1 
ATOM   6520 C C   . SER E 5 14  ? 38.781  -11.297 -3.475  1.00 53.53  ? 14  SER L C   1 
ATOM   6521 O O   . SER E 5 14  ? 38.292  -10.287 -2.960  1.00 59.51  ? 14  SER L O   1 
ATOM   6522 C CB  . SER E 5 14  ? 39.557  -11.466 -5.841  1.00 50.85  ? 14  SER L CB  1 
ATOM   6523 O OG  . SER E 5 14  ? 39.508  -12.322 -6.968  1.00 71.64  ? 14  SER L OG  1 
ATOM   6524 N N   . LEU E 5 15  ? 39.660  -12.075 -2.849  1.00 48.35  ? 15  LEU L N   1 
ATOM   6525 C CA  . LEU E 5 15  ? 40.155  -11.725 -1.526  1.00 58.20  ? 15  LEU L CA  1 
ATOM   6526 C C   . LEU E 5 15  ? 40.879  -10.387 -1.571  1.00 63.72  ? 15  LEU L C   1 
ATOM   6527 O O   . LEU E 5 15  ? 41.727  -10.153 -2.437  1.00 61.43  ? 15  LEU L O   1 
ATOM   6528 C CB  . LEU E 5 15  ? 41.088  -12.818 -1.008  1.00 54.57  ? 15  LEU L CB  1 
ATOM   6529 C CG  . LEU E 5 15  ? 40.493  -13.802 -0.002  1.00 60.65  ? 15  LEU L CG  1 
ATOM   6530 C CD1 . LEU E 5 15  ? 41.324  -15.070 0.036   1.00 54.59  ? 15  LEU L CD1 1 
ATOM   6531 C CD2 . LEU E 5 15  ? 40.424  -13.167 1.377   1.00 55.13  ? 15  LEU L CD2 1 
ATOM   6532 N N   . GLY E 5 16  ? 40.533  -9.506  -0.637  1.00 63.22  ? 16  GLY L N   1 
ATOM   6533 C CA  . GLY E 5 16  ? 41.148  -8.200  -0.554  1.00 63.73  ? 16  GLY L CA  1 
ATOM   6534 C C   . GLY E 5 16  ? 40.581  -7.153  -1.486  1.00 61.14  ? 16  GLY L C   1 
ATOM   6535 O O   . GLY E 5 16  ? 41.048  -6.008  -1.456  1.00 71.92  ? 16  GLY L O   1 
ATOM   6536 N N   . GLU E 5 17  ? 39.592  -7.496  -2.307  1.00 48.00  ? 17  GLU L N   1 
ATOM   6537 C CA  . GLU E 5 17  ? 39.020  -6.556  -3.255  1.00 50.36  ? 17  GLU L CA  1 
ATOM   6538 C C   . GLU E 5 17  ? 37.732  -5.958  -2.691  1.00 56.36  ? 17  GLU L C   1 
ATOM   6539 O O   . GLU E 5 17  ? 37.324  -6.235  -1.561  1.00 59.89  ? 17  GLU L O   1 
ATOM   6540 C CB  . GLU E 5 17  ? 38.785  -7.231  -4.608  1.00 51.74  ? 17  GLU L CB  1 
ATOM   6541 C CG  . GLU E 5 17  ? 40.069  -7.519  -5.381  1.00 62.77  ? 17  GLU L CG  1 
ATOM   6542 C CD  . GLU E 5 17  ? 39.815  -7.970  -6.811  1.00 82.08  ? 17  GLU L CD  1 
ATOM   6543 O OE1 . GLU E 5 17  ? 38.637  -8.174  -7.178  1.00 73.49  ? 17  GLU L OE1 1 
ATOM   6544 O OE2 . GLU E 5 17  ? 40.797  -8.118  -7.569  1.00 74.25  ? 17  GLU L OE2 1 
ATOM   6545 N N   . ARG E 5 18  ? 37.090  -5.117  -3.495  1.00 55.05  ? 18  ARG L N   1 
ATOM   6546 C CA  . ARG E 5 18  ? 35.937  -4.341  -3.061  1.00 57.79  ? 18  ARG L CA  1 
ATOM   6547 C C   . ARG E 5 18  ? 34.641  -5.014  -3.496  1.00 57.60  ? 18  ARG L C   1 
ATOM   6548 O O   . ARG E 5 18  ? 34.515  -5.466  -4.637  1.00 60.91  ? 18  ARG L O   1 
ATOM   6549 C CB  . ARG E 5 18  ? 36.006  -2.921  -3.626  1.00 64.53  ? 18  ARG L CB  1 
ATOM   6550 C CG  . ARG E 5 18  ? 34.833  -2.034  -3.241  1.00 66.85  ? 18  ARG L CG  1 
ATOM   6551 C CD  . ARG E 5 18  ? 34.908  -0.702  -3.964  1.00 58.48  ? 18  ARG L CD  1 
ATOM   6552 N NE  . ARG E 5 18  ? 34.930  -0.879  -5.411  1.00 57.88  ? 18  ARG L NE  1 
ATOM   6553 C CZ  . ARG E 5 18  ? 35.083  0.108   -6.283  1.00 65.75  ? 18  ARG L CZ  1 
ATOM   6554 N NH1 . ARG E 5 18  ? 35.245  1.360   -5.889  1.00 65.97  ? 18  ARG L NH1 1 
ATOM   6555 N NH2 . ARG E 5 18  ? 35.073  -0.170  -7.584  1.00 64.07  ? 18  ARG L NH2 1 
ATOM   6556 N N   . ALA E 5 19  ? 33.682  -5.078  -2.576  1.00 52.29  ? 19  ALA L N   1 
ATOM   6557 C CA  . ALA E 5 19  ? 32.361  -5.630  -2.838  1.00 46.19  ? 19  ALA L CA  1 
ATOM   6558 C C   . ALA E 5 19  ? 31.322  -4.534  -2.653  1.00 58.31  ? 19  ALA L C   1 
ATOM   6559 O O   . ALA E 5 19  ? 31.341  -3.820  -1.644  1.00 55.67  ? 19  ALA L O   1 
ATOM   6560 C CB  . ALA E 5 19  ? 32.062  -6.812  -1.911  1.00 42.56  ? 19  ALA L CB  1 
ATOM   6561 N N   . THR E 5 20  ? 30.421  -4.402  -3.625  1.00 58.78  ? 20  THR L N   1 
ATOM   6562 C CA  . THR E 5 20  ? 29.411  -3.352  -3.619  1.00 51.91  ? 20  THR L CA  1 
ATOM   6563 C C   . THR E 5 20  ? 28.034  -3.971  -3.802  1.00 48.57  ? 20  THR L C   1 
ATOM   6564 O O   . THR E 5 20  ? 27.829  -4.778  -4.713  1.00 58.86  ? 20  THR L O   1 
ATOM   6565 C CB  . THR E 5 20  ? 29.674  -2.323  -4.723  1.00 54.50  ? 20  THR L CB  1 
ATOM   6566 O OG1 . THR E 5 20  ? 31.002  -1.801  -4.584  1.00 63.62  ? 20  THR L OG1 1 
ATOM   6567 C CG2 . THR E 5 20  ? 28.672  -1.181  -4.639  1.00 56.46  ? 20  THR L CG2 1 
ATOM   6568 N N   . ILE E 5 21  ? 27.095  -3.590  -2.938  1.00 46.02  ? 21  ILE L N   1 
ATOM   6569 C CA  . ILE E 5 21  ? 25.715  -4.052  -3.004  1.00 47.47  ? 21  ILE L CA  1 
ATOM   6570 C C   . ILE E 5 21  ? 24.802  -2.840  -2.906  1.00 47.85  ? 21  ILE L C   1 
ATOM   6571 O O   . ILE E 5 21  ? 24.940  -2.028  -1.985  1.00 50.28  ? 21  ILE L O   1 
ATOM   6572 C CB  . ILE E 5 21  ? 25.396  -5.062  -1.885  1.00 52.69  ? 21  ILE L CB  1 
ATOM   6573 C CG1 . ILE E 5 21  ? 26.160  -6.365  -2.103  1.00 40.28  ? 21  ILE L CG1 1 
ATOM   6574 C CG2 . ILE E 5 21  ? 23.904  -5.344  -1.820  1.00 51.05  ? 21  ILE L CG2 1 
ATOM   6575 C CD1 . ILE E 5 21  ? 26.087  -7.298  -0.925  1.00 35.24  ? 21  ILE L CD1 1 
ATOM   6576 N N   . ASN E 5 22  ? 23.873  -2.718  -3.849  1.00 53.51  ? 22  ASN L N   1 
ATOM   6577 C CA  . ASN E 5 22  ? 22.921  -1.617  -3.871  1.00 56.54  ? 22  ASN L CA  1 
ATOM   6578 C C   . ASN E 5 22  ? 21.556  -2.089  -3.390  1.00 45.27  ? 22  ASN L C   1 
ATOM   6579 O O   . ASN E 5 22  ? 21.199  -3.259  -3.539  1.00 57.77  ? 22  ASN L O   1 
ATOM   6580 C CB  . ASN E 5 22  ? 22.800  -1.028  -5.278  1.00 42.95  ? 22  ASN L CB  1 
ATOM   6581 C CG  . ASN E 5 22  ? 24.145  -0.684  -5.880  1.00 57.75  ? 22  ASN L CG  1 
ATOM   6582 O OD1 . ASN E 5 22  ? 24.707  0.377   -5.607  1.00 67.35  ? 22  ASN L OD1 1 
ATOM   6583 N ND2 . ASN E 5 22  ? 24.672  -1.582  -6.704  1.00 64.83  ? 22  ASN L ND2 1 
ATOM   6584 N N   . CYS E 5 23  ? 20.796  -1.162  -2.807  1.00 50.42  ? 23  CYS L N   1 
ATOM   6585 C CA  . CYS E 5 23  ? 19.454  -1.434  -2.305  1.00 49.70  ? 23  CYS L CA  1 
ATOM   6586 C C   . CYS E 5 23  ? 18.537  -0.296  -2.728  1.00 59.01  ? 23  CYS L C   1 
ATOM   6587 O O   . CYS E 5 23  ? 18.831  0.871   -2.454  1.00 59.99  ? 23  CYS L O   1 
ATOM   6588 C CB  . CYS E 5 23  ? 19.456  -1.578  -0.778  1.00 58.50  ? 23  CYS L CB  1 
ATOM   6589 S SG  . CYS E 5 23  ? 17.873  -2.041  -0.022  1.00 74.21  ? 23  CYS L SG  1 
ATOM   6590 N N   . LYS E 5 24  ? 17.435  -0.635  -3.392  1.00 49.96  ? 24  LYS L N   1 
ATOM   6591 C CA  . LYS E 5 24  ? 16.508  0.346   -3.944  1.00 46.33  ? 24  LYS L CA  1 
ATOM   6592 C C   . LYS E 5 24  ? 15.170  0.256   -3.223  1.00 60.67  ? 24  LYS L C   1 
ATOM   6593 O O   . LYS E 5 24  ? 14.613  -0.837  -3.070  1.00 56.48  ? 24  LYS L O   1 
ATOM   6594 C CB  . LYS E 5 24  ? 16.316  0.127   -5.446  1.00 64.00  ? 24  LYS L CB  1 
ATOM   6595 C CG  . LYS E 5 24  ? 16.541  1.366   -6.296  1.00 63.63  ? 24  LYS L CG  1 
ATOM   6596 C CD  . LYS E 5 24  ? 15.527  2.452   -5.985  1.00 55.53  ? 24  LYS L CD  1 
ATOM   6597 C CE  . LYS E 5 24  ? 15.728  3.654   -6.890  1.00 62.95  ? 24  LYS L CE  1 
ATOM   6598 N NZ  . LYS E 5 24  ? 14.759  4.740   -6.583  1.00 63.67  ? 24  LYS L NZ  1 
ATOM   6599 N N   . SER E 5 25  ? 14.654  1.405   -2.794  1.00 60.15  ? 25  SER L N   1 
ATOM   6600 C CA  . SER E 5 25  ? 13.426  1.488   -2.017  1.00 49.19  ? 25  SER L CA  1 
ATOM   6601 C C   . SER E 5 25  ? 12.284  1.993   -2.885  1.00 52.84  ? 25  SER L C   1 
ATOM   6602 O O   . SER E 5 25  ? 12.465  2.905   -3.698  1.00 68.90  ? 25  SER L O   1 
ATOM   6603 C CB  . SER E 5 25  ? 13.598  2.421   -0.817  1.00 54.65  ? 25  SER L CB  1 
ATOM   6604 O OG  . SER E 5 25  ? 14.700  2.025   -0.025  1.00 76.47  ? 25  SER L OG  1 
ATOM   6605 N N   . SER E 5 26  ? 11.103  1.399   -2.702  1.00 46.54  ? 26  SER L N   1 
ATOM   6606 C CA  . SER E 5 26  ? 9.935   1.854   -3.447  1.00 49.14  ? 26  SER L CA  1 
ATOM   6607 C C   . SER E 5 26  ? 9.534   3.266   -3.046  1.00 51.06  ? 26  SER L C   1 
ATOM   6608 O O   . SER E 5 26  ? 9.021   4.025   -3.876  1.00 62.55  ? 26  SER L O   1 
ATOM   6609 C CB  . SER E 5 26  ? 8.770   0.889   -3.241  1.00 37.16  ? 26  SER L CB  1 
ATOM   6610 O OG  . SER E 5 26  ? 8.378   0.849   -1.884  1.00 46.59  ? 26  SER L OG  1 
ATOM   6611 N N   . GLN E 5 27  ? 9.750   3.635   -1.788  1.00 51.71  ? 27  GLN L N   1 
ATOM   6612 C CA  . GLN E 5 27  ? 9.487   4.986   -1.328  1.00 48.64  ? 27  GLN L CA  1 
ATOM   6613 C C   . GLN E 5 27  ? 10.587  5.399   -0.364  1.00 49.85  ? 27  GLN L C   1 
ATOM   6614 O O   . GLN E 5 27  ? 11.332  4.564   0.156   1.00 58.68  ? 27  GLN L O   1 
ATOM   6615 C CB  . GLN E 5 27  ? 8.115   5.099   -0.658  1.00 39.89  ? 27  GLN L CB  1 
ATOM   6616 C CG  . GLN E 5 27  ? 7.937   4.166   0.513   1.00 39.47  ? 27  GLN L CG  1 
ATOM   6617 C CD  . GLN E 5 27  ? 6.765   4.550   1.386   1.00 57.42  ? 27  GLN L CD  1 
ATOM   6618 O OE1 . GLN E 5 27  ? 6.790   5.582   2.057   1.00 52.75  ? 27  GLN L OE1 1 
ATOM   6619 N NE2 . GLN E 5 27  ? 5.724   3.725   1.378   1.00 56.22  ? 27  GLN L NE2 1 
ATOM   6620 N N   . SER E 5 28  A 10.692  6.705   -0.142  1.00 52.46  ? 27  SER L N   1 
ATOM   6621 C CA  . SER E 5 28  A 11.732  7.228   0.730   1.00 46.31  ? 27  SER L CA  1 
ATOM   6622 C C   . SER E 5 28  A 11.524  6.744   2.158   1.00 53.00  ? 27  SER L C   1 
ATOM   6623 O O   . SER E 5 28  A 10.406  6.767   2.679   1.00 64.52  ? 27  SER L O   1 
ATOM   6624 C CB  . SER E 5 28  A 11.742  8.754   0.688   1.00 52.83  ? 27  SER L CB  1 
ATOM   6625 O OG  . SER E 5 28  A 12.694  9.275   1.599   1.00 47.35  ? 27  SER L OG  1 
ATOM   6626 N N   . VAL E 5 29  B 12.607  6.297   2.786   1.00 59.07  ? 27  VAL L N   1 
ATOM   6627 C CA  . VAL E 5 29  B 12.595  5.904   4.187   1.00 52.58  ? 27  VAL L CA  1 
ATOM   6628 C C   . VAL E 5 29  B 13.320  6.935   5.048   1.00 54.00  ? 27  VAL L C   1 
ATOM   6629 O O   . VAL E 5 29  B 13.747  6.629   6.158   1.00 55.12  ? 27  VAL L O   1 
ATOM   6630 C CB  . VAL E 5 29  B 13.192  4.502   4.379   1.00 52.31  ? 27  VAL L CB  1 
ATOM   6631 C CG1 . VAL E 5 29  B 12.335  3.457   3.679   1.00 52.71  ? 27  VAL L CG1 1 
ATOM   6632 C CG2 . VAL E 5 29  B 14.614  4.468   3.856   1.00 46.53  ? 27  VAL L CG2 1 
ATOM   6633 N N   . LEU E 5 30  C 13.467  8.154   4.537   1.00 65.89  ? 27  LEU L N   1 
ATOM   6634 C CA  . LEU E 5 30  C 14.145  9.219   5.260   1.00 55.05  ? 27  LEU L CA  1 
ATOM   6635 C C   . LEU E 5 30  C 13.194  9.879   6.248   1.00 66.27  ? 27  LEU L C   1 
ATOM   6636 O O   . LEU E 5 30  C 12.109  10.332  5.869   1.00 60.91  ? 27  LEU L O   1 
ATOM   6637 C CB  . LEU E 5 30  C 14.678  10.262  4.281   1.00 51.43  ? 27  LEU L CB  1 
ATOM   6638 C CG  . LEU E 5 30  C 15.077  11.604  4.891   1.00 54.47  ? 27  LEU L CG  1 
ATOM   6639 C CD1 . LEU E 5 30  C 16.401  11.481  5.620   1.00 55.35  ? 27  LEU L CD1 1 
ATOM   6640 C CD2 . LEU E 5 30  C 15.143  12.675  3.817   1.00 61.07  ? 27  LEU L CD2 1 
ATOM   6641 N N   . TYR E 5 31  D 13.603  9.937   7.512   1.00 68.37  ? 27  TYR L N   1 
ATOM   6642 C CA  . TYR E 5 31  D 12.864  10.673  8.531   1.00 68.13  ? 27  TYR L CA  1 
ATOM   6643 C C   . TYR E 5 31  D 13.353  12.116  8.495   1.00 74.50  ? 27  TYR L C   1 
ATOM   6644 O O   . TYR E 5 31  D 14.513  12.394  8.815   1.00 79.99  ? 27  TYR L O   1 
ATOM   6645 C CB  . TYR E 5 31  D 13.058  10.041  9.906   1.00 70.29  ? 27  TYR L CB  1 
ATOM   6646 C CG  . TYR E 5 31  D 11.940  10.344  10.875  1.00 78.43  ? 27  TYR L CG  1 
ATOM   6647 C CD1 . TYR E 5 31  D 10.775  9.587   10.882  1.00 81.11  ? 27  TYR L CD1 1 
ATOM   6648 C CD2 . TYR E 5 31  D 12.050  11.387  11.782  1.00 82.15  ? 27  TYR L CD2 1 
ATOM   6649 C CE1 . TYR E 5 31  D 9.751   9.863   11.767  1.00 88.97  ? 27  TYR L CE1 1 
ATOM   6650 C CE2 . TYR E 5 31  D 11.034  11.668  12.669  1.00 81.57  ? 27  TYR L CE2 1 
ATOM   6651 C CZ  . TYR E 5 31  D 9.887   10.907  12.657  1.00 80.67  ? 27  TYR L CZ  1 
ATOM   6652 O OH  . TYR E 5 31  D 8.880   11.195  13.546  1.00 71.87  ? 27  TYR L OH  1 
ATOM   6653 N N   . SER E 5 32  E 12.471  13.033  8.091   1.00 79.90  ? 27  SER L N   1 
ATOM   6654 C CA  . SER E 5 32  E 12.902  14.388  7.761   1.00 83.96  ? 27  SER L CA  1 
ATOM   6655 C C   . SER E 5 32  E 13.437  15.127  8.984   1.00 94.43  ? 27  SER L C   1 
ATOM   6656 O O   . SER E 5 32  E 14.534  15.696  8.944   1.00 93.68  ? 27  SER L O   1 
ATOM   6657 C CB  . SER E 5 32  E 11.746  15.161  7.124   1.00 84.70  ? 27  SER L CB  1 
ATOM   6658 O OG  . SER E 5 32  E 11.255  14.488  5.978   1.00 72.75  ? 27  SER L OG  1 
ATOM   6659 N N   . SER E 5 33  F 12.683  15.122  10.086  1.00 82.74  ? 27  SER L N   1 
ATOM   6660 C CA  . SER E 5 33  F 13.064  15.927  11.244  1.00 72.94  ? 27  SER L CA  1 
ATOM   6661 C C   . SER E 5 33  F 14.352  15.420  11.888  1.00 89.69  ? 27  SER L C   1 
ATOM   6662 O O   . SER E 5 33  F 15.237  16.217  12.220  1.00 94.93  ? 27  SER L O   1 
ATOM   6663 C CB  . SER E 5 33  F 11.922  15.953  12.257  1.00 86.45  ? 27  SER L CB  1 
ATOM   6664 O OG  . SER E 5 33  F 11.407  14.654  12.476  1.00 85.15  ? 27  SER L OG  1 
ATOM   6665 N N   . ILE E 5 34  ? 14.483  14.102  12.069  1.00 94.37  ? 28  ILE L N   1 
ATOM   6666 C CA  . ILE E 5 34  ? 15.701  13.547  12.662  1.00 85.29  ? 28  ILE L CA  1 
ATOM   6667 C C   . ILE E 5 34  ? 16.824  13.415  11.646  1.00 82.54  ? 28  ILE L C   1 
ATOM   6668 O O   . ILE E 5 34  ? 17.981  13.213  12.040  1.00 69.94  ? 28  ILE L O   1 
ATOM   6669 C CB  . ILE E 5 34  ? 15.395  12.194  13.339  1.00 74.55  ? 28  ILE L CB  1 
ATOM   6670 C CG1 . ILE E 5 34  ? 16.178  12.051  14.649  1.00 77.91  ? 28  ILE L CG1 1 
ATOM   6671 C CG2 . ILE E 5 34  ? 15.694  11.026  12.403  1.00 68.18  ? 28  ILE L CG2 1 
ATOM   6672 C CD1 . ILE E 5 34  ? 15.839  10.795  15.441  1.00 55.65  ? 28  ILE L CD1 1 
ATOM   6673 N N   . ASN E 5 35  ? 16.516  13.546  10.352  1.00 77.53  ? 29  ASN L N   1 
ATOM   6674 C CA  . ASN E 5 35  ? 17.513  13.558  9.279   1.00 77.82  ? 29  ASN L CA  1 
ATOM   6675 C C   . ASN E 5 35  ? 18.340  12.273  9.263   1.00 73.90  ? 29  ASN L C   1 
ATOM   6676 O O   . ASN E 5 35  ? 19.567  12.294  9.144   1.00 75.72  ? 29  ASN L O   1 
ATOM   6677 C CB  . ASN E 5 35  ? 18.415  14.791  9.384   1.00 85.36  ? 29  ASN L CB  1 
ATOM   6678 C CG  . ASN E 5 35  ? 19.219  15.033  8.121   1.00 93.34  ? 29  ASN L CG  1 
ATOM   6679 O OD1 . ASN E 5 35  ? 18.679  15.016  7.014   1.00 84.32  ? 29  ASN L OD1 1 
ATOM   6680 N ND2 . ASN E 5 35  ? 20.520  15.244  8.279   1.00 99.81  ? 29  ASN L ND2 1 
ATOM   6681 N N   . LYS E 5 36  ? 17.655  11.139  9.386   1.00 71.93  ? 30  LYS L N   1 
ATOM   6682 C CA  . LYS E 5 36  ? 18.303  9.839   9.295   1.00 67.69  ? 30  LYS L CA  1 
ATOM   6683 C C   . LYS E 5 36  ? 17.390  8.863   8.567   1.00 60.93  ? 30  LYS L C   1 
ATOM   6684 O O   . LYS E 5 36  ? 16.183  8.820   8.821   1.00 59.35  ? 30  LYS L O   1 
ATOM   6685 C CB  . LYS E 5 36  ? 18.676  9.298   10.684  1.00 54.68  ? 30  LYS L CB  1 
ATOM   6686 C CG  . LYS E 5 36  ? 19.831  10.049  11.335  1.00 58.92  ? 30  LYS L CG  1 
ATOM   6687 C CD  . LYS E 5 36  ? 20.825  9.102   11.979  1.00 59.73  ? 30  LYS L CD  1 
ATOM   6688 C CE  . LYS E 5 36  ? 22.165  9.780   12.222  1.00 59.02  ? 30  LYS L CE  1 
ATOM   6689 N NZ  . LYS E 5 36  ? 22.820  10.192  10.948  1.00 59.39  ? 30  LYS L NZ  1 
ATOM   6690 N N   . ASN E 5 37  ? 17.974  8.092   7.651   1.00 57.96  ? 31  ASN L N   1 
ATOM   6691 C CA  . ASN E 5 37  ? 17.227  7.084   6.912   1.00 56.14  ? 31  ASN L CA  1 
ATOM   6692 C C   . ASN E 5 37  ? 17.096  5.819   7.750   1.00 57.18  ? 31  ASN L C   1 
ATOM   6693 O O   . ASN E 5 37  ? 18.081  5.329   8.309   1.00 64.44  ? 31  ASN L O   1 
ATOM   6694 C CB  . ASN E 5 37  ? 17.914  6.769   5.584   1.00 51.38  ? 31  ASN L CB  1 
ATOM   6695 C CG  . ASN E 5 37  ? 17.994  7.972   4.666   1.00 53.01  ? 31  ASN L CG  1 
ATOM   6696 O OD1 . ASN E 5 37  ? 17.088  8.222   3.872   1.00 55.56  ? 31  ASN L OD1 1 
ATOM   6697 N ND2 . ASN E 5 37  ? 19.087  8.719   4.764   1.00 54.78  ? 31  ASN L ND2 1 
ATOM   6698 N N   . TYR E 5 38  ? 15.876  5.290   7.832   1.00 47.87  ? 32  TYR L N   1 
ATOM   6699 C CA  . TYR E 5 38  ? 15.599  4.085   8.616   1.00 47.54  ? 32  TYR L CA  1 
ATOM   6700 C C   . TYR E 5 38  ? 15.849  2.847   7.753   1.00 44.39  ? 32  TYR L C   1 
ATOM   6701 O O   . TYR E 5 38  ? 14.937  2.157   7.295   1.00 45.31  ? 32  TYR L O   1 
ATOM   6702 C CB  . TYR E 5 38  ? 14.179  4.129   9.168   1.00 55.48  ? 32  TYR L CB  1 
ATOM   6703 C CG  . TYR E 5 38  ? 14.060  4.907   10.465  1.00 58.19  ? 32  TYR L CG  1 
ATOM   6704 C CD1 . TYR E 5 38  ? 14.538  6.208   10.567  1.00 56.89  ? 32  TYR L CD1 1 
ATOM   6705 C CD2 . TYR E 5 38  ? 13.469  4.339   11.587  1.00 63.26  ? 32  TYR L CD2 1 
ATOM   6706 C CE1 . TYR E 5 38  ? 14.436  6.919   11.751  1.00 63.36  ? 32  TYR L CE1 1 
ATOM   6707 C CE2 . TYR E 5 38  ? 13.362  5.043   12.775  1.00 67.83  ? 32  TYR L CE2 1 
ATOM   6708 C CZ  . TYR E 5 38  ? 13.847  6.333   12.851  1.00 68.42  ? 32  TYR L CZ  1 
ATOM   6709 O OH  . TYR E 5 38  ? 13.743  7.040   14.030  1.00 55.05  ? 32  TYR L OH  1 
ATOM   6710 N N   . LEU E 5 39  ? 17.137  2.582   7.538   1.00 46.80  ? 33  LEU L N   1 
ATOM   6711 C CA  . LEU E 5 39  ? 17.613  1.484   6.709   1.00 48.04  ? 33  LEU L CA  1 
ATOM   6712 C C   . LEU E 5 39  ? 18.659  0.701   7.486   1.00 55.06  ? 33  LEU L C   1 
ATOM   6713 O O   . LEU E 5 39  ? 19.475  1.286   8.204   1.00 61.66  ? 33  LEU L O   1 
ATOM   6714 C CB  . LEU E 5 39  ? 18.212  2.008   5.390   1.00 53.00  ? 33  LEU L CB  1 
ATOM   6715 C CG  . LEU E 5 39  ? 18.394  1.098   4.167   1.00 46.72  ? 33  LEU L CG  1 
ATOM   6716 C CD1 . LEU E 5 39  ? 19.599  0.159   4.291   1.00 43.24  ? 33  LEU L CD1 1 
ATOM   6717 C CD2 . LEU E 5 39  ? 17.115  0.319   3.889   1.00 43.70  ? 33  LEU L CD2 1 
ATOM   6718 N N   . ALA E 5 40  ? 18.637  -0.621  7.341   1.00 52.84  ? 34  ALA L N   1 
ATOM   6719 C CA  . ALA E 5 40  ? 19.573  -1.488  8.037   1.00 41.40  ? 34  ALA L CA  1 
ATOM   6720 C C   . ALA E 5 40  ? 20.146  -2.514  7.069   1.00 36.45  ? 34  ALA L C   1 
ATOM   6721 O O   . ALA E 5 40  ? 19.554  -2.819  6.032   1.00 43.09  ? 34  ALA L O   1 
ATOM   6722 C CB  . ALA E 5 40  ? 18.908  -2.195  9.226   1.00 40.98  ? 34  ALA L CB  1 
ATOM   6723 N N   . TRP E 5 41  ? 21.319  -3.035  7.421   1.00 44.11  ? 35  TRP L N   1 
ATOM   6724 C CA  . TRP E 5 41  ? 21.983  -4.094  6.676   1.00 44.34  ? 35  TRP L CA  1 
ATOM   6725 C C   . TRP E 5 41  ? 22.243  -5.282  7.592   1.00 50.07  ? 35  TRP L C   1 
ATOM   6726 O O   . TRP E 5 41  ? 22.656  -5.110  8.744   1.00 49.99  ? 35  TRP L O   1 
ATOM   6727 C CB  . TRP E 5 41  ? 23.305  -3.605  6.074   1.00 42.63  ? 35  TRP L CB  1 
ATOM   6728 C CG  . TRP E 5 41  ? 23.125  -2.712  4.896   1.00 46.93  ? 35  TRP L CG  1 
ATOM   6729 C CD1 . TRP E 5 41  ? 23.140  -1.349  4.888   1.00 50.94  ? 35  TRP L CD1 1 
ATOM   6730 C CD2 . TRP E 5 41  ? 22.890  -3.120  3.544   1.00 54.61  ? 35  TRP L CD2 1 
ATOM   6731 N NE1 . TRP E 5 41  ? 22.933  -0.881  3.612   1.00 54.97  ? 35  TRP L NE1 1 
ATOM   6732 C CE2 . TRP E 5 41  ? 22.776  -1.949  2.769   1.00 54.02  ? 35  TRP L CE2 1 
ATOM   6733 C CE3 . TRP E 5 41  ? 22.765  -4.362  2.913   1.00 49.15  ? 35  TRP L CE3 1 
ATOM   6734 C CZ2 . TRP E 5 41  ? 22.544  -1.984  1.396   1.00 58.28  ? 35  TRP L CZ2 1 
ATOM   6735 C CZ3 . TRP E 5 41  ? 22.536  -4.394  1.551   1.00 47.62  ? 35  TRP L CZ3 1 
ATOM   6736 C CH2 . TRP E 5 41  ? 22.428  -3.213  0.807   1.00 56.96  ? 35  TRP L CH2 1 
ATOM   6737 N N   . TYR E 5 42  ? 22.010  -6.490  7.074   1.00 38.74  ? 36  TYR L N   1 
ATOM   6738 C CA  . TYR E 5 42  ? 22.172  -7.718  7.841   1.00 33.97  ? 36  TYR L CA  1 
ATOM   6739 C C   . TYR E 5 42  ? 23.084  -8.693  7.107   1.00 35.38  ? 36  TYR L C   1 
ATOM   6740 O O   . TYR E 5 42  ? 23.062  -8.774  5.875   1.00 34.15  ? 36  TYR L O   1 
ATOM   6741 C CB  . TYR E 5 42  ? 20.819  -8.387  8.110   1.00 34.74  ? 36  TYR L CB  1 
ATOM   6742 C CG  . TYR E 5 42  ? 19.926  -7.618  9.055   1.00 43.98  ? 36  TYR L CG  1 
ATOM   6743 C CD1 . TYR E 5 42  ? 19.078  -6.622  8.588   1.00 42.30  ? 36  TYR L CD1 1 
ATOM   6744 C CD2 . TYR E 5 42  ? 19.927  -7.891  10.417  1.00 43.79  ? 36  TYR L CD2 1 
ATOM   6745 C CE1 . TYR E 5 42  ? 18.259  -5.917  9.453   1.00 40.20  ? 36  TYR L CE1 1 
ATOM   6746 C CE2 . TYR E 5 42  ? 19.113  -7.193  11.287  1.00 44.12  ? 36  TYR L CE2 1 
ATOM   6747 C CZ  . TYR E 5 42  ? 18.281  -6.207  10.800  1.00 45.68  ? 36  TYR L CZ  1 
ATOM   6748 O OH  . TYR E 5 42  ? 17.468  -5.509  11.663  1.00 46.16  ? 36  TYR L OH  1 
ATOM   6749 N N   . GLN E 5 43  ? 23.879  -9.439  7.873   1.00 36.82  ? 37  GLN L N   1 
ATOM   6750 C CA  . GLN E 5 43  ? 24.741  -10.488 7.343   1.00 38.50  ? 37  GLN L CA  1 
ATOM   6751 C C   . GLN E 5 43  ? 24.280  -11.834 7.882   1.00 38.60  ? 37  GLN L C   1 
ATOM   6752 O O   . GLN E 5 43  ? 24.120  -11.998 9.096   1.00 43.79  ? 37  GLN L O   1 
ATOM   6753 C CB  . GLN E 5 43  ? 26.205  -10.254 7.718   1.00 34.55  ? 37  GLN L CB  1 
ATOM   6754 C CG  . GLN E 5 43  ? 27.144  -11.329 7.193   1.00 42.08  ? 37  GLN L CG  1 
ATOM   6755 C CD  . GLN E 5 43  ? 28.533  -11.249 7.795   1.00 47.22  ? 37  GLN L CD  1 
ATOM   6756 O OE1 . GLN E 5 43  ? 28.690  -11.107 9.008   1.00 49.92  ? 37  GLN L OE1 1 
ATOM   6757 N NE2 . GLN E 5 43  ? 29.551  -11.342 6.947   1.00 50.94  ? 37  GLN L NE2 1 
ATOM   6758 N N   . GLN E 5 44  ? 24.070  -12.794 6.985   1.00 34.79  ? 38  GLN L N   1 
ATOM   6759 C CA  . GLN E 5 44  ? 23.639  -14.136 7.372   1.00 45.25  ? 38  GLN L CA  1 
ATOM   6760 C C   . GLN E 5 44  ? 24.607  -15.140 6.758   1.00 47.76  ? 38  GLN L C   1 
ATOM   6761 O O   . GLN E 5 44  ? 24.504  -15.470 5.573   1.00 34.41  ? 38  GLN L O   1 
ATOM   6762 C CB  . GLN E 5 44  ? 22.202  -14.412 6.937   1.00 40.94  ? 38  GLN L CB  1 
ATOM   6763 C CG  . GLN E 5 44  ? 21.662  -15.749 7.446   1.00 41.26  ? 38  GLN L CG  1 
ATOM   6764 C CD  . GLN E 5 44  ? 20.290  -16.091 6.895   1.00 38.17  ? 38  GLN L CD  1 
ATOM   6765 O OE1 . GLN E 5 44  ? 19.937  -15.699 5.781   1.00 38.59  ? 38  GLN L OE1 1 
ATOM   6766 N NE2 . GLN E 5 44  ? 19.507  -16.826 7.677   1.00 33.18  ? 38  GLN L NE2 1 
ATOM   6767 N N   . LYS E 5 45  ? 25.559  -15.604 7.563   1.00 49.06  ? 39  LYS L N   1 
ATOM   6768 C CA  . LYS E 5 45  ? 26.421  -16.689 7.138   1.00 56.48  ? 39  LYS L CA  1 
ATOM   6769 C C   . LYS E 5 45  ? 25.623  -17.991 7.102   1.00 61.98  ? 39  LYS L C   1 
ATOM   6770 O O   . LYS E 5 45  ? 24.652  -18.151 7.849   1.00 52.48  ? 39  LYS L O   1 
ATOM   6771 C CB  . LYS E 5 45  ? 27.620  -16.818 8.076   1.00 55.55  ? 39  LYS L CB  1 
ATOM   6772 C CG  . LYS E 5 45  ? 28.479  -15.560 8.132   1.00 60.38  ? 39  LYS L CG  1 
ATOM   6773 C CD  . LYS E 5 45  ? 29.916  -15.862 8.537   1.00 58.92  ? 39  LYS L CD  1 
ATOM   6774 C CE  . LYS E 5 45  ? 29.995  -16.470 9.927   1.00 80.97  ? 39  LYS L CE  1 
ATOM   6775 N NZ  . LYS E 5 45  ? 31.402  -16.763 10.321  1.00 79.58  ? 39  LYS L NZ  1 
ATOM   6776 N N   . PRO E 5 46  ? 25.996  -18.927 6.227   1.00 64.64  ? 40  PRO L N   1 
ATOM   6777 C CA  . PRO E 5 46  ? 25.209  -20.160 6.089   1.00 60.92  ? 40  PRO L CA  1 
ATOM   6778 C C   . PRO E 5 46  ? 25.085  -20.903 7.410   1.00 54.54  ? 40  PRO L C   1 
ATOM   6779 O O   . PRO E 5 46  ? 26.056  -21.063 8.151   1.00 57.79  ? 40  PRO L O   1 
ATOM   6780 C CB  . PRO E 5 46  ? 26.001  -20.971 5.059   1.00 59.36  ? 40  PRO L CB  1 
ATOM   6781 C CG  . PRO E 5 46  ? 26.745  -19.948 4.274   1.00 71.17  ? 40  PRO L CG  1 
ATOM   6782 C CD  . PRO E 5 46  ? 27.102  -18.870 5.255   1.00 56.09  ? 40  PRO L CD  1 
ATOM   6783 N N   . GLY E 5 47  ? 23.866  -21.353 7.697   1.00 50.13  ? 41  GLY L N   1 
ATOM   6784 C CA  . GLY E 5 47  ? 23.587  -22.098 8.907   1.00 54.47  ? 41  GLY L CA  1 
ATOM   6785 C C   . GLY E 5 47  ? 23.512  -21.278 10.173  1.00 60.34  ? 41  GLY L C   1 
ATOM   6786 O O   . GLY E 5 47  ? 23.425  -21.860 11.262  1.00 56.00  ? 41  GLY L O   1 
ATOM   6787 N N   . GLN E 5 48  ? 23.537  -19.953 10.074  1.00 59.33  ? 42  GLN L N   1 
ATOM   6788 C CA  . GLN E 5 48  ? 23.520  -19.089 11.241  1.00 51.55  ? 42  GLN L CA  1 
ATOM   6789 C C   . GLN E 5 48  ? 22.451  -18.019 11.090  1.00 38.06  ? 42  GLN L C   1 
ATOM   6790 O O   . GLN E 5 48  ? 22.062  -17.677 9.969   1.00 49.44  ? 42  GLN L O   1 
ATOM   6791 C CB  . GLN E 5 48  ? 24.890  -18.428 11.459  1.00 56.14  ? 42  GLN L CB  1 
ATOM   6792 C CG  . GLN E 5 48  ? 25.900  -19.338 12.128  1.00 58.89  ? 42  GLN L CG  1 
ATOM   6793 C CD  . GLN E 5 48  ? 27.063  -18.574 12.715  1.00 70.08  ? 42  GLN L CD  1 
ATOM   6794 O OE1 . GLN E 5 48  ? 27.185  -17.365 12.523  1.00 78.72  ? 42  GLN L OE1 1 
ATOM   6795 N NE2 . GLN E 5 48  ? 27.925  -19.275 13.443  1.00 82.83  ? 42  GLN L NE2 1 
ATOM   6796 N N   . PRO E 5 49  ? 21.943  -17.489 12.200  1.00 42.48  ? 43  PRO L N   1 
ATOM   6797 C CA  . PRO E 5 49  ? 20.912  -16.443 12.125  1.00 43.72  ? 43  PRO L CA  1 
ATOM   6798 C C   . PRO E 5 49  ? 21.481  -15.150 11.569  1.00 39.99  ? 43  PRO L C   1 
ATOM   6799 O O   . PRO E 5 49  ? 22.704  -14.947 11.576  1.00 43.02  ? 43  PRO L O   1 
ATOM   6800 C CB  . PRO E 5 49  ? 20.469  -16.277 13.587  1.00 45.09  ? 43  PRO L CB  1 
ATOM   6801 C CG  . PRO E 5 49  ? 21.612  -16.798 14.394  1.00 37.49  ? 43  PRO L CG  1 
ATOM   6802 C CD  . PRO E 5 49  ? 22.191  -17.918 13.589  1.00 35.91  ? 43  PRO L CD  1 
ATOM   6803 N N   . PRO E 5 50  ? 20.629  -14.261 11.055  1.00 45.76  ? 44  PRO L N   1 
ATOM   6804 C CA  . PRO E 5 50  ? 21.127  -12.980 10.538  1.00 43.03  ? 44  PRO L CA  1 
ATOM   6805 C C   . PRO E 5 50  ? 21.770  -12.142 11.633  1.00 44.59  ? 44  PRO L C   1 
ATOM   6806 O O   . PRO E 5 50  ? 21.360  -12.170 12.796  1.00 43.96  ? 44  PRO L O   1 
ATOM   6807 C CB  . PRO E 5 50  ? 19.867  -12.299 9.988   1.00 38.49  ? 44  PRO L CB  1 
ATOM   6808 C CG  . PRO E 5 50  ? 18.878  -13.398 9.795   1.00 38.21  ? 44  PRO L CG  1 
ATOM   6809 C CD  . PRO E 5 50  ? 19.179  -14.416 10.851  1.00 42.95  ? 44  PRO L CD  1 
ATOM   6810 N N   . LYS E 5 51  ? 22.791  -11.384 11.242  1.00 40.62  ? 45  LYS L N   1 
ATOM   6811 C CA  . LYS E 5 51  ? 23.532  -10.514 12.144  1.00 39.54  ? 45  LYS L CA  1 
ATOM   6812 C C   . LYS E 5 51  ? 23.439  -9.082  11.637  1.00 46.52  ? 45  LYS L C   1 
ATOM   6813 O O   . LYS E 5 51  ? 23.705  -8.821  10.460  1.00 51.62  ? 45  LYS L O   1 
ATOM   6814 C CB  . LYS E 5 51  ? 24.996  -10.954 12.243  1.00 35.29  ? 45  LYS L CB  1 
ATOM   6815 C CG  . LYS E 5 51  ? 25.870  -10.060 13.105  1.00 52.07  ? 45  LYS L CG  1 
ATOM   6816 C CD  . LYS E 5 51  ? 27.334  -10.475 13.024  1.00 46.97  ? 45  LYS L CD  1 
ATOM   6817 C CE  . LYS E 5 51  ? 28.228  -9.490  13.767  1.00 59.65  ? 45  LYS L CE  1 
ATOM   6818 N NZ  . LYS E 5 51  ? 29.679  -9.778  13.579  1.00 63.24  ? 45  LYS L NZ  1 
ATOM   6819 N N   . LEU E 5 52  ? 23.062  -8.160  12.520  1.00 42.58  ? 46  LEU L N   1 
ATOM   6820 C CA  . LEU E 5 52  ? 22.940  -6.758  12.135  1.00 38.17  ? 46  LEU L CA  1 
ATOM   6821 C C   . LEU E 5 52  ? 24.322  -6.126  12.001  1.00 46.84  ? 46  LEU L C   1 
ATOM   6822 O O   . LEU E 5 52  ? 25.113  -6.146  12.950  1.00 55.28  ? 46  LEU L O   1 
ATOM   6823 C CB  . LEU E 5 52  ? 22.109  -6.000  13.163  1.00 37.01  ? 46  LEU L CB  1 
ATOM   6824 C CG  . LEU E 5 52  ? 22.054  -4.486  12.976  1.00 40.21  ? 46  LEU L CG  1 
ATOM   6825 C CD1 . LEU E 5 52  ? 21.380  -4.142  11.660  1.00 50.39  ? 46  LEU L CD1 1 
ATOM   6826 C CD2 . LEU E 5 52  ? 21.328  -3.847  14.142  1.00 42.55  ? 46  LEU L CD2 1 
ATOM   6827 N N   . LEU E 5 53  ? 24.613  -5.564  10.827  1.00 45.15  ? 47  LEU L N   1 
ATOM   6828 C CA  . LEU E 5 53  ? 25.908  -4.942  10.560  1.00 53.33  ? 47  LEU L CA  1 
ATOM   6829 C C   . LEU E 5 53  ? 25.863  -3.424  10.690  1.00 52.86  ? 47  LEU L C   1 
ATOM   6830 O O   . LEU E 5 53  ? 26.629  -2.838  11.461  1.00 54.55  ? 47  LEU L O   1 
ATOM   6831 C CB  . LEU E 5 53  ? 26.404  -5.316  9.158   1.00 47.28  ? 47  LEU L CB  1 
ATOM   6832 C CG  . LEU E 5 53  ? 26.892  -6.743  8.928   1.00 44.71  ? 47  LEU L CG  1 
ATOM   6833 C CD1 . LEU E 5 53  ? 27.432  -6.871  7.514   1.00 36.36  ? 47  LEU L CD1 1 
ATOM   6834 C CD2 . LEU E 5 53  ? 27.946  -7.126  9.958   1.00 40.56  ? 47  LEU L CD2 1 
ATOM   6835 N N   . ILE E 5 54  ? 24.991  -2.772  9.924   1.00 53.27  ? 48  ILE L N   1 
ATOM   6836 C CA  . ILE E 5 54  ? 24.915  -1.318  9.872   1.00 58.39  ? 48  ILE L CA  1 
ATOM   6837 C C   . ILE E 5 54  ? 23.456  -0.903  9.985   1.00 49.02  ? 48  ILE L C   1 
ATOM   6838 O O   . ILE E 5 54  ? 22.590  -1.476  9.315   1.00 43.59  ? 48  ILE L O   1 
ATOM   6839 C CB  . ILE E 5 54  ? 25.551  -0.764  8.583   1.00 50.49  ? 48  ILE L CB  1 
ATOM   6840 C CG1 . ILE E 5 54  ? 27.025  -1.175  8.511   1.00 45.79  ? 48  ILE L CG1 1 
ATOM   6841 C CG2 . ILE E 5 54  ? 25.393  0.747   8.508   1.00 50.49  ? 48  ILE L CG2 1 
ATOM   6842 C CD1 . ILE E 5 54  ? 27.881  -0.285  7.648   1.00 53.02  ? 48  ILE L CD1 1 
ATOM   6843 N N   . TYR E 5 55  ? 23.187  0.083   10.839  1.00 52.87  ? 49  TYR L N   1 
ATOM   6844 C CA  . TYR E 5 55  ? 21.853  0.636   11.024  1.00 60.89  ? 49  TYR L CA  1 
ATOM   6845 C C   . TYR E 5 55  ? 21.867  2.133   10.726  1.00 59.08  ? 49  TYR L C   1 
ATOM   6846 O O   . TYR E 5 55  ? 22.915  2.787   10.757  1.00 54.73  ? 49  TYR L O   1 
ATOM   6847 C CB  . TYR E 5 55  ? 21.324  0.391   12.443  1.00 56.87  ? 49  TYR L CB  1 
ATOM   6848 C CG  . TYR E 5 55  ? 22.131  1.054   13.538  1.00 60.16  ? 49  TYR L CG  1 
ATOM   6849 C CD1 . TYR E 5 55  ? 23.287  0.462   14.026  1.00 57.61  ? 49  TYR L CD1 1 
ATOM   6850 C CD2 . TYR E 5 55  ? 21.731  2.266   14.091  1.00 63.79  ? 49  TYR L CD2 1 
ATOM   6851 C CE1 . TYR E 5 55  ? 24.028  1.057   15.027  1.00 62.72  ? 49  TYR L CE1 1 
ATOM   6852 C CE2 . TYR E 5 55  ? 22.468  2.871   15.095  1.00 60.08  ? 49  TYR L CE2 1 
ATOM   6853 C CZ  . TYR E 5 55  ? 23.615  2.261   15.559  1.00 62.80  ? 49  TYR L CZ  1 
ATOM   6854 O OH  . TYR E 5 55  ? 24.356  2.853   16.556  1.00 66.31  ? 49  TYR L OH  1 
ATOM   6855 N N   . TRP E 5 56  ? 20.682  2.666   10.425  1.00 50.10  ? 50  TRP L N   1 
ATOM   6856 C CA  . TRP E 5 56  ? 20.497  4.030   9.943   1.00 45.78  ? 50  TRP L CA  1 
ATOM   6857 C C   . TRP E 5 56  ? 21.259  4.299   8.644   1.00 54.20  ? 50  TRP L C   1 
ATOM   6858 O O   . TRP E 5 56  ? 21.641  5.440   8.366   1.00 55.63  ? 50  TRP L O   1 
ATOM   6859 C CB  . TRP E 5 56  ? 20.885  5.065   11.004  1.00 41.57  ? 50  TRP L CB  1 
ATOM   6860 C CG  . TRP E 5 56  ? 19.709  5.525   11.786  1.00 48.84  ? 50  TRP L CG  1 
ATOM   6861 C CD1 . TRP E 5 56  ? 18.407  5.515   11.383  1.00 54.58  ? 50  TRP L CD1 1 
ATOM   6862 C CD2 . TRP E 5 56  ? 19.714  6.050   13.116  1.00 47.53  ? 50  TRP L CD2 1 
ATOM   6863 N NE1 . TRP E 5 56  ? 17.599  6.010   12.377  1.00 50.33  ? 50  TRP L NE1 1 
ATOM   6864 C CE2 . TRP E 5 56  ? 18.377  6.345   13.453  1.00 55.82  ? 50  TRP L CE2 1 
ATOM   6865 C CE3 . TRP E 5 56  ? 20.718  6.305   14.056  1.00 52.00  ? 50  TRP L CE3 1 
ATOM   6866 C CZ2 . TRP E 5 56  ? 18.019  6.881   14.688  1.00 59.96  ? 50  TRP L CZ2 1 
ATOM   6867 C CZ3 . TRP E 5 56  ? 20.361  6.837   15.281  1.00 60.01  ? 50  TRP L CZ3 1 
ATOM   6868 C CH2 . TRP E 5 56  ? 19.024  7.119   15.587  1.00 44.76  ? 50  TRP L CH2 1 
ATOM   6869 N N   . ALA E 5 57  ? 21.536  3.267   7.856   1.00 57.52  ? 51  ALA L N   1 
ATOM   6870 C CA  . ALA E 5 57  ? 22.199  3.269   6.549   1.00 59.95  ? 51  ALA L CA  1 
ATOM   6871 C C   . ALA E 5 57  ? 23.666  3.733   6.572   1.00 55.85  ? 51  ALA L C   1 
ATOM   6872 O O   . ALA E 5 57  ? 24.369  3.571   5.559   1.00 60.94  ? 51  ALA L O   1 
ATOM   6873 C CB  . ALA E 5 57  ? 21.448  4.090   5.485   1.00 55.43  ? 51  ALA L CB  1 
ATOM   6874 N N   . SER E 5 58  ? 24.141  4.357   7.654   1.00 62.16  ? 52  SER L N   1 
ATOM   6875 C CA  . SER E 5 58  ? 25.560  4.702   7.724   1.00 51.26  ? 52  SER L CA  1 
ATOM   6876 C C   . SER E 5 58  ? 26.257  4.276   9.008   1.00 57.09  ? 52  SER L C   1 
ATOM   6877 O O   . SER E 5 58  ? 27.487  4.196   9.002   1.00 67.93  ? 52  SER L O   1 
ATOM   6878 C CB  . SER E 5 58  ? 25.765  6.213   7.527   1.00 60.33  ? 52  SER L CB  1 
ATOM   6879 O OG  . SER E 5 58  ? 25.287  6.638   6.260   1.00 74.45  ? 52  SER L OG  1 
ATOM   6880 N N   . THR E 5 59  ? 25.549  3.998   10.103  1.00 59.23  ? 53  THR L N   1 
ATOM   6881 C CA  . THR E 5 59  ? 26.181  3.774   11.401  1.00 55.62  ? 53  THR L CA  1 
ATOM   6882 C C   . THR E 5 59  ? 26.477  2.288   11.616  1.00 58.22  ? 53  THR L C   1 
ATOM   6883 O O   . THR E 5 59  ? 25.560  1.461   11.610  1.00 60.87  ? 53  THR L O   1 
ATOM   6884 C CB  . THR E 5 59  ? 25.279  4.323   12.511  1.00 54.61  ? 53  THR L CB  1 
ATOM   6885 O OG1 . THR E 5 59  ? 24.944  5.686   12.215  1.00 54.31  ? 53  THR L OG1 1 
ATOM   6886 C CG2 . THR E 5 59  ? 25.959  4.255   13.873  1.00 51.86  ? 53  THR L CG2 1 
ATOM   6887 N N   . ARG E 5 60  ? 27.753  1.951   11.815  1.00 56.97  ? 54  ARG L N   1 
ATOM   6888 C CA  . ARG E 5 60  ? 28.129  0.567   12.080  1.00 57.86  ? 54  ARG L CA  1 
ATOM   6889 C C   . ARG E 5 60  ? 27.669  0.130   13.467  1.00 58.70  ? 54  ARG L C   1 
ATOM   6890 O O   . ARG E 5 60  ? 27.634  0.920   14.414  1.00 56.55  ? 54  ARG L O   1 
ATOM   6891 C CB  . ARG E 5 60  ? 29.642  0.385   11.963  1.00 55.99  ? 54  ARG L CB  1 
ATOM   6892 C CG  . ARG E 5 60  ? 30.174  0.502   10.554  1.00 53.53  ? 54  ARG L CG  1 
ATOM   6893 C CD  . ARG E 5 60  ? 31.653  0.174   10.505  1.00 57.37  ? 54  ARG L CD  1 
ATOM   6894 N NE  . ARG E 5 60  ? 32.486  1.367   10.593  1.00 64.38  ? 54  ARG L NE  1 
ATOM   6895 C CZ  . ARG E 5 60  ? 32.853  2.099   9.549   1.00 75.25  ? 54  ARG L CZ  1 
ATOM   6896 N NH1 . ARG E 5 60  ? 32.456  1.801   8.323   1.00 71.18  ? 54  ARG L NH1 1 
ATOM   6897 N NH2 . ARG E 5 60  ? 33.639  3.155   9.740   1.00 79.88  ? 54  ARG L NH2 1 
ATOM   6898 N N   . GLU E 5 61  ? 27.307  -1.146  13.579  1.00 53.08  ? 55  GLU L N   1 
ATOM   6899 C CA  . GLU E 5 61  ? 26.993  -1.730  14.875  1.00 59.41  ? 55  GLU L CA  1 
ATOM   6900 C C   . GLU E 5 61  ? 28.281  -2.014  15.644  1.00 61.73  ? 55  GLU L C   1 
ATOM   6901 O O   . GLU E 5 61  ? 29.356  -2.171  15.057  1.00 65.21  ? 55  GLU L O   1 
ATOM   6902 C CB  . GLU E 5 61  ? 26.178  -3.018  14.705  1.00 53.88  ? 55  GLU L CB  1 
ATOM   6903 C CG  . GLU E 5 61  ? 25.723  -3.670  16.014  1.00 51.33  ? 55  GLU L CG  1 
ATOM   6904 C CD  . GLU E 5 61  ? 24.619  -2.895  16.723  1.00 59.40  ? 55  GLU L CD  1 
ATOM   6905 O OE1 . GLU E 5 61  ? 23.493  -3.427  16.824  1.00 66.94  ? 55  GLU L OE1 1 
ATOM   6906 O OE2 . GLU E 5 61  ? 24.874  -1.761  17.187  1.00 68.44  ? 55  GLU L OE2 1 
ATOM   6907 N N   . SER E 5 62  ? 28.170  -2.052  16.972  1.00 48.28  ? 56  SER L N   1 
ATOM   6908 C CA  . SER E 5 62  ? 29.336  -2.315  17.805  1.00 51.02  ? 56  SER L CA  1 
ATOM   6909 C C   . SER E 5 62  ? 29.922  -3.684  17.481  1.00 57.39  ? 56  SER L C   1 
ATOM   6910 O O   . SER E 5 62  ? 29.192  -4.670  17.346  1.00 63.90  ? 56  SER L O   1 
ATOM   6911 C CB  . SER E 5 62  ? 28.959  -2.235  19.286  1.00 69.87  ? 56  SER L CB  1 
ATOM   6912 O OG  . SER E 5 62  ? 30.078  -2.515  20.110  1.00 77.64  ? 56  SER L OG  1 
ATOM   6913 N N   . GLY E 5 63  ? 31.246  -3.738  17.349  1.00 54.41  ? 57  GLY L N   1 
ATOM   6914 C CA  . GLY E 5 63  ? 31.937  -4.962  17.012  1.00 52.27  ? 57  GLY L CA  1 
ATOM   6915 C C   . GLY E 5 63  ? 32.101  -5.216  15.530  1.00 65.06  ? 57  GLY L C   1 
ATOM   6916 O O   . GLY E 5 63  ? 32.894  -6.088  15.151  1.00 69.00  ? 57  GLY L O   1 
ATOM   6917 N N   . VAL E 5 64  ? 31.380  -4.491  14.686  1.00 70.12  ? 58  VAL L N   1 
ATOM   6918 C CA  . VAL E 5 64  ? 31.526  -4.648  13.236  1.00 59.43  ? 58  VAL L CA  1 
ATOM   6919 C C   . VAL E 5 64  ? 32.848  -4.026  12.796  1.00 65.96  ? 58  VAL L C   1 
ATOM   6920 O O   . VAL E 5 64  ? 33.137  -2.872  13.160  1.00 74.05  ? 58  VAL L O   1 
ATOM   6921 C CB  . VAL E 5 64  ? 30.344  -4.003  12.512  1.00 54.04  ? 58  VAL L CB  1 
ATOM   6922 C CG1 . VAL E 5 64  ? 30.518  -4.108  11.007  1.00 63.03  ? 58  VAL L CG1 1 
ATOM   6923 C CG2 . VAL E 5 64  ? 29.047  -4.663  12.944  1.00 48.79  ? 58  VAL L CG2 1 
ATOM   6924 N N   . PRO E 5 65  ? 33.674  -4.736  12.032  1.00 64.45  ? 59  PRO L N   1 
ATOM   6925 C CA  . PRO E 5 65  ? 34.961  -4.174  11.607  1.00 73.17  ? 59  PRO L CA  1 
ATOM   6926 C C   . PRO E 5 65  ? 34.784  -3.008  10.646  1.00 61.01  ? 59  PRO L C   1 
ATOM   6927 O O   . PRO E 5 65  ? 33.735  -2.821  10.026  1.00 57.72  ? 59  PRO L O   1 
ATOM   6928 C CB  . PRO E 5 65  ? 35.660  -5.356  10.926  1.00 68.76  ? 59  PRO L CB  1 
ATOM   6929 C CG  . PRO E 5 65  ? 34.555  -6.267  10.519  1.00 56.99  ? 59  PRO L CG  1 
ATOM   6930 C CD  . PRO E 5 65  ? 33.490  -6.120  11.565  1.00 58.63  ? 59  PRO L CD  1 
ATOM   6931 N N   . ASP E 5 66  ? 35.854  -2.218  10.524  1.00 61.92  ? 60  ASP L N   1 
ATOM   6932 C CA  . ASP E 5 66  ? 35.776  -0.938  9.827   1.00 69.13  ? 60  ASP L CA  1 
ATOM   6933 C C   . ASP E 5 66  ? 35.561  -1.081  8.324   1.00 65.58  ? 60  ASP L C   1 
ATOM   6934 O O   . ASP E 5 66  ? 35.124  -0.119  7.686   1.00 67.00  ? 60  ASP L O   1 
ATOM   6935 C CB  . ASP E 5 66  ? 37.044  -0.120  10.086  1.00 71.14  ? 60  ASP L CB  1 
ATOM   6936 C CG  . ASP E 5 66  ? 37.600  -0.329  11.482  1.00 89.48  ? 60  ASP L CG  1 
ATOM   6937 O OD1 . ASP E 5 66  ? 38.781  -0.723  11.598  1.00 94.49  ? 60  ASP L OD1 1 
ATOM   6938 O OD2 . ASP E 5 66  ? 36.853  -0.111  12.460  1.00 89.58  ? 60  ASP L OD2 1 
ATOM   6939 N N   . ARG E 5 67  ? 35.854  -2.246  7.739   1.00 62.14  ? 61  ARG L N   1 
ATOM   6940 C CA  . ARG E 5 67  ? 35.754  -2.386  6.289   1.00 59.74  ? 61  ARG L CA  1 
ATOM   6941 C C   . ARG E 5 67  ? 34.316  -2.463  5.786   1.00 60.28  ? 61  ARG L C   1 
ATOM   6942 O O   . ARG E 5 67  ? 34.102  -2.403  4.569   1.00 52.57  ? 61  ARG L O   1 
ATOM   6943 C CB  . ARG E 5 67  ? 36.528  -3.618  5.824   1.00 61.51  ? 61  ARG L CB  1 
ATOM   6944 C CG  . ARG E 5 67  ? 35.894  -4.936  6.206   1.00 66.19  ? 61  ARG L CG  1 
ATOM   6945 C CD  . ARG E 5 67  ? 36.788  -6.099  5.818   1.00 67.09  ? 61  ARG L CD  1 
ATOM   6946 N NE  . ARG E 5 67  ? 36.362  -7.335  6.462   1.00 63.79  ? 61  ARG L NE  1 
ATOM   6947 C CZ  . ARG E 5 67  ? 36.634  -7.650  7.721   1.00 62.30  ? 61  ARG L CZ  1 
ATOM   6948 N NH1 . ARG E 5 67  ? 37.333  -6.841  8.501   1.00 62.78  ? 61  ARG L NH1 1 
ATOM   6949 N NH2 . ARG E 5 67  ? 36.190  -8.804  8.210   1.00 51.44  ? 61  ARG L NH2 1 
ATOM   6950 N N   . PHE E 5 68  ? 33.338  -2.610  6.675   1.00 63.05  ? 62  PHE L N   1 
ATOM   6951 C CA  . PHE E 5 68  ? 31.930  -2.510  6.311   1.00 51.50  ? 62  PHE L CA  1 
ATOM   6952 C C   . PHE E 5 68  ? 31.493  -1.054  6.393   1.00 52.25  ? 62  PHE L C   1 
ATOM   6953 O O   . PHE E 5 68  ? 31.695  -0.399  7.420   1.00 64.52  ? 62  PHE L O   1 
ATOM   6954 C CB  . PHE E 5 68  ? 31.065  -3.369  7.234   1.00 48.75  ? 62  PHE L CB  1 
ATOM   6955 C CG  . PHE E 5 68  ? 31.310  -4.841  7.097   1.00 48.89  ? 62  PHE L CG  1 
ATOM   6956 C CD1 . PHE E 5 68  ? 32.323  -5.458  7.812   1.00 59.93  ? 62  PHE L CD1 1 
ATOM   6957 C CD2 . PHE E 5 68  ? 30.532  -5.608  6.250   1.00 44.10  ? 62  PHE L CD2 1 
ATOM   6958 C CE1 . PHE E 5 68  ? 32.553  -6.812  7.682   1.00 58.00  ? 62  PHE L CE1 1 
ATOM   6959 C CE2 . PHE E 5 68  ? 30.757  -6.963  6.119   1.00 42.08  ? 62  PHE L CE2 1 
ATOM   6960 C CZ  . PHE E 5 68  ? 31.768  -7.565  6.834   1.00 42.82  ? 62  PHE L CZ  1 
ATOM   6961 N N   . SER E 5 69  ? 30.901  -0.546  5.315   1.00 52.68  ? 63  SER L N   1 
ATOM   6962 C CA  . SER E 5 69  ? 30.443  0.835   5.285   1.00 54.83  ? 63  SER L CA  1 
ATOM   6963 C C   . SER E 5 69  ? 29.117  0.917   4.547   1.00 46.70  ? 63  SER L C   1 
ATOM   6964 O O   . SER E 5 69  ? 28.898  0.204   3.564   1.00 53.75  ? 63  SER L O   1 
ATOM   6965 C CB  . SER E 5 69  ? 31.470  1.759   4.617   1.00 47.41  ? 63  SER L CB  1 
ATOM   6966 O OG  . SER E 5 69  ? 31.500  1.560   3.214   1.00 73.13  ? 63  SER L OG  1 
ATOM   6967 N N   . GLY E 5 70  ? 28.237  1.788   5.030   1.00 44.09  ? 64  GLY L N   1 
ATOM   6968 C CA  . GLY E 5 70  ? 26.966  2.041   4.385   1.00 45.51  ? 64  GLY L CA  1 
ATOM   6969 C C   . GLY E 5 70  ? 26.901  3.472   3.890   1.00 54.67  ? 64  GLY L C   1 
ATOM   6970 O O   . GLY E 5 70  ? 27.527  4.370   4.455   1.00 69.10  ? 64  GLY L O   1 
ATOM   6971 N N   . SER E 5 71  ? 26.136  3.678   2.821   1.00 46.32  ? 65  SER L N   1 
ATOM   6972 C CA  . SER E 5 71  ? 25.990  5.005   2.241   1.00 47.10  ? 65  SER L CA  1 
ATOM   6973 C C   . SER E 5 71  ? 24.672  5.072   1.487   1.00 47.98  ? 65  SER L C   1 
ATOM   6974 O O   . SER E 5 71  ? 24.052  4.047   1.188   1.00 56.68  ? 65  SER L O   1 
ATOM   6975 C CB  . SER E 5 71  ? 27.166  5.349   1.317   1.00 55.08  ? 65  SER L CB  1 
ATOM   6976 O OG  . SER E 5 71  ? 27.310  4.390   0.283   1.00 64.22  ? 65  SER L OG  1 
ATOM   6977 N N   . GLY E 5 72  ? 24.252  6.292   1.188   1.00 46.65  ? 66  GLY L N   1 
ATOM   6978 C CA  . GLY E 5 72  ? 23.036  6.542   0.444   1.00 47.59  ? 66  GLY L CA  1 
ATOM   6979 C C   . GLY E 5 72  ? 21.968  7.204   1.300   1.00 50.86  ? 66  GLY L C   1 
ATOM   6980 O O   . GLY E 5 72  ? 22.046  7.262   2.527   1.00 64.60  ? 66  GLY L O   1 
ATOM   6981 N N   . SER E 5 73  ? 20.952  7.713   0.611   1.00 44.48  ? 67  SER L N   1 
ATOM   6982 C CA  . SER E 5 73  ? 19.841  8.372   1.279   1.00 43.01  ? 67  SER L CA  1 
ATOM   6983 C C   . SER E 5 73  ? 18.612  8.264   0.392   1.00 43.00  ? 67  SER L C   1 
ATOM   6984 O O   . SER E 5 73  ? 18.710  7.968   -0.802  1.00 47.17  ? 67  SER L O   1 
ATOM   6985 C CB  . SER E 5 73  ? 20.157  9.838   1.592   1.00 47.17  ? 67  SER L CB  1 
ATOM   6986 O OG  . SER E 5 73  ? 19.050  10.486  2.194   1.00 45.09  ? 67  SER L OG  1 
ATOM   6987 N N   . GLY E 5 74  ? 17.453  8.501   0.996   1.00 42.26  ? 68  GLY L N   1 
ATOM   6988 C CA  . GLY E 5 74  ? 16.207  8.464   0.259   1.00 47.60  ? 68  GLY L CA  1 
ATOM   6989 C C   . GLY E 5 74  ? 15.789  7.062   -0.127  1.00 56.63  ? 68  GLY L C   1 
ATOM   6990 O O   . GLY E 5 74  ? 15.346  6.284   0.724   1.00 56.47  ? 68  GLY L O   1 
ATOM   6991 N N   . THR E 5 75  ? 15.915  6.734   -1.415  1.00 63.74  ? 69  THR L N   1 
ATOM   6992 C CA  . THR E 5 75  ? 15.570  5.412   -1.918  1.00 59.65  ? 69  THR L CA  1 
ATOM   6993 C C   . THR E 5 75  ? 16.773  4.602   -2.378  1.00 54.62  ? 69  THR L C   1 
ATOM   6994 O O   . THR E 5 75  ? 16.618  3.410   -2.665  1.00 63.49  ? 69  THR L O   1 
ATOM   6995 C CB  . THR E 5 75  ? 14.572  5.524   -3.082  1.00 60.92  ? 69  THR L CB  1 
ATOM   6996 O OG1 . THR E 5 75  ? 15.212  6.137   -4.208  1.00 65.62  ? 69  THR L OG1 1 
ATOM   6997 C CG2 . THR E 5 75  ? 13.358  6.354   -2.674  1.00 46.74  ? 69  THR L CG2 1 
ATOM   6998 N N   . ASP E 5 76  ? 17.956  5.205   -2.460  1.00 52.79  ? 70  ASP L N   1 
ATOM   6999 C CA  . ASP E 5 76  ? 19.164  4.528   -2.917  1.00 55.71  ? 70  ASP L CA  1 
ATOM   7000 C C   . ASP E 5 76  ? 20.122  4.344   -1.748  1.00 59.25  ? 70  ASP L C   1 
ATOM   7001 O O   . ASP E 5 76  ? 20.464  5.313   -1.062  1.00 57.78  ? 70  ASP L O   1 
ATOM   7002 C CB  . ASP E 5 76  ? 19.842  5.319   -4.037  1.00 71.16  ? 70  ASP L CB  1 
ATOM   7003 C CG  . ASP E 5 76  ? 19.138  5.158   -5.372  1.00 82.20  ? 70  ASP L CG  1 
ATOM   7004 O OD1 . ASP E 5 76  ? 19.160  4.038   -5.925  1.00 94.48  ? 70  ASP L OD1 1 
ATOM   7005 O OD2 . ASP E 5 76  ? 18.553  6.148   -5.863  1.00 77.79  ? 70  ASP L OD2 1 
ATOM   7006 N N   . PHE E 5 77  ? 20.549  3.103   -1.526  1.00 56.29  ? 71  PHE L N   1 
ATOM   7007 C CA  . PHE E 5 77  ? 21.474  2.775   -0.452  1.00 51.68  ? 71  PHE L CA  1 
ATOM   7008 C C   . PHE E 5 77  ? 22.459  1.730   -0.951  1.00 46.71  ? 71  PHE L C   1 
ATOM   7009 O O   . PHE E 5 77  ? 22.090  0.835   -1.716  1.00 49.16  ? 71  PHE L O   1 
ATOM   7010 C CB  . PHE E 5 77  ? 20.734  2.261   0.791   1.00 51.99  ? 71  PHE L CB  1 
ATOM   7011 C CG  . PHE E 5 77  ? 19.731  3.235   1.346   1.00 47.75  ? 71  PHE L CG  1 
ATOM   7012 C CD1 . PHE E 5 77  ? 20.126  4.235   2.219   1.00 49.09  ? 71  PHE L CD1 1 
ATOM   7013 C CD2 . PHE E 5 77  ? 18.392  3.151   0.995   1.00 49.44  ? 71  PHE L CD2 1 
ATOM   7014 C CE1 . PHE E 5 77  ? 19.206  5.133   2.732   1.00 48.11  ? 71  PHE L CE1 1 
ATOM   7015 C CE2 . PHE E 5 77  ? 17.468  4.046   1.504   1.00 50.18  ? 71  PHE L CE2 1 
ATOM   7016 C CZ  . PHE E 5 77  ? 17.876  5.039   2.374   1.00 46.13  ? 71  PHE L CZ  1 
ATOM   7017 N N   . THR E 5 78  ? 23.716  1.857   -0.532  1.00 48.19  ? 72  THR L N   1 
ATOM   7018 C CA  . THR E 5 78  ? 24.765  0.939   -0.950  1.00 55.79  ? 72  THR L CA  1 
ATOM   7019 C C   . THR E 5 78  ? 25.499  0.397   0.268   1.00 53.11  ? 72  THR L C   1 
ATOM   7020 O O   . THR E 5 78  ? 25.802  1.140   1.206   1.00 49.48  ? 72  THR L O   1 
ATOM   7021 C CB  . THR E 5 78  ? 25.775  1.612   -1.893  1.00 55.56  ? 72  THR L CB  1 
ATOM   7022 O OG1 . THR E 5 78  ? 26.807  2.236   -1.119  1.00 76.17  ? 72  THR L OG1 1 
ATOM   7023 C CG2 . THR E 5 78  ? 25.092  2.663   -2.757  1.00 51.48  ? 72  THR L CG2 1 
ATOM   7024 N N   . LEU E 5 79  ? 25.778  -0.901  0.245   1.00 53.44  ? 73  LEU L N   1 
ATOM   7025 C CA  . LEU E 5 79  ? 26.646  -1.546  1.219   1.00 50.76  ? 73  LEU L CA  1 
ATOM   7026 C C   . LEU E 5 79  ? 27.976  -1.850  0.549   1.00 52.82  ? 73  LEU L C   1 
ATOM   7027 O O   . LEU E 5 79  ? 28.009  -2.476  -0.516  1.00 53.57  ? 73  LEU L O   1 
ATOM   7028 C CB  . LEU E 5 79  ? 26.018  -2.831  1.757   1.00 59.96  ? 73  LEU L CB  1 
ATOM   7029 C CG  . LEU E 5 79  ? 26.955  -3.713  2.579   1.00 52.01  ? 73  LEU L CG  1 
ATOM   7030 C CD1 . LEU E 5 79  ? 27.398  -2.980  3.834   1.00 47.61  ? 73  LEU L CD1 1 
ATOM   7031 C CD2 . LEU E 5 79  ? 26.282  -5.033  2.922   1.00 53.40  ? 73  LEU L CD2 1 
ATOM   7032 N N   . THR E 5 80  ? 29.066  -1.403  1.164   1.00 55.93  ? 74  THR L N   1 
ATOM   7033 C CA  . THR E 5 80  ? 30.394  -1.536  0.586   1.00 61.11  ? 74  THR L CA  1 
ATOM   7034 C C   . THR E 5 80  ? 31.293  -2.321  1.527   1.00 51.19  ? 74  THR L C   1 
ATOM   7035 O O   . THR E 5 80  ? 31.406  -1.985  2.711   1.00 43.52  ? 74  THR L O   1 
ATOM   7036 C CB  . THR E 5 80  ? 31.010  -0.167  0.295   1.00 58.03  ? 74  THR L CB  1 
ATOM   7037 O OG1 . THR E 5 80  ? 30.232  0.504   -0.705  1.00 50.17  ? 74  THR L OG1 1 
ATOM   7038 C CG2 . THR E 5 80  ? 32.441  -0.324  -0.198  1.00 52.30  ? 74  THR L CG2 1 
ATOM   7039 N N   . ILE E 5 81  ? 31.929  -3.360  0.996   1.00 50.57  ? 75  ILE L N   1 
ATOM   7040 C CA  . ILE E 5 81  ? 32.930  -4.137  1.715   1.00 52.97  ? 75  ILE L CA  1 
ATOM   7041 C C   . ILE E 5 81  ? 34.252  -3.942  0.991   1.00 57.50  ? 75  ILE L C   1 
ATOM   7042 O O   . ILE E 5 81  ? 34.452  -4.478  -0.107  1.00 64.07  ? 75  ILE L O   1 
ATOM   7043 C CB  . ILE E 5 81  ? 32.567  -5.624  1.791   1.00 53.76  ? 75  ILE L CB  1 
ATOM   7044 C CG1 . ILE E 5 81  ? 31.292  -5.827  2.604   1.00 44.06  ? 75  ILE L CG1 1 
ATOM   7045 C CG2 . ILE E 5 81  ? 33.711  -6.421  2.395   1.00 47.51  ? 75  ILE L CG2 1 
ATOM   7046 C CD1 . ILE E 5 81  ? 30.836  -7.261  2.626   1.00 40.47  ? 75  ILE L CD1 1 
ATOM   7047 N N   . SER E 5 82  ? 35.152  -3.178  1.594   1.00 59.94  ? 76  SER L N   1 
ATOM   7048 C CA  . SER E 5 82  ? 36.492  -3.009  1.056   1.00 65.34  ? 76  SER L CA  1 
ATOM   7049 C C   . SER E 5 82  ? 37.422  -4.030  1.696   1.00 72.65  ? 76  SER L C   1 
ATOM   7050 O O   . SER E 5 82  ? 37.300  -4.332  2.887   1.00 76.21  ? 76  SER L O   1 
ATOM   7051 C CB  . SER E 5 82  ? 36.998  -1.591  1.310   1.00 53.92  ? 76  SER L CB  1 
ATOM   7052 O OG  . SER E 5 82  ? 37.021  -1.316  2.698   1.00 43.03  ? 76  SER L OG  1 
ATOM   7053 N N   . SER E 5 83  ? 38.344  -4.568  0.897   1.00 66.77  ? 77  SER L N   1 
ATOM   7054 C CA  . SER E 5 83  ? 39.240  -5.641  1.334   1.00 78.83  ? 77  SER L CA  1 
ATOM   7055 C C   . SER E 5 83  ? 38.432  -6.833  1.853   1.00 77.58  ? 77  SER L C   1 
ATOM   7056 O O   . SER E 5 83  ? 38.502  -7.212  3.026   1.00 74.35  ? 77  SER L O   1 
ATOM   7057 C CB  . SER E 5 83  ? 40.239  -5.144  2.387   1.00 82.68  ? 77  SER L CB  1 
ATOM   7058 O OG  . SER E 5 83  ? 41.112  -4.163  1.852   1.00 91.68  ? 77  SER L OG  1 
ATOM   7059 N N   . LEU E 5 84  ? 37.643  -7.409  0.946   1.00 74.89  ? 78  LEU L N   1 
ATOM   7060 C CA  . LEU E 5 84  ? 36.788  -8.540  1.282   1.00 64.74  ? 78  LEU L CA  1 
ATOM   7061 C C   . LEU E 5 84  ? 37.622  -9.737  1.718   1.00 64.77  ? 78  LEU L C   1 
ATOM   7062 O O   . LEU E 5 84  ? 38.602  -10.102 1.062   1.00 71.47  ? 78  LEU L O   1 
ATOM   7063 C CB  . LEU E 5 84  ? 35.920  -8.906  0.080   1.00 63.17  ? 78  LEU L CB  1 
ATOM   7064 C CG  . LEU E 5 84  ? 35.054  -10.158 0.176   1.00 55.40  ? 78  LEU L CG  1 
ATOM   7065 C CD1 . LEU E 5 84  ? 33.630  -9.822  -0.212  1.00 60.21  ? 78  LEU L CD1 1 
ATOM   7066 C CD2 . LEU E 5 84  ? 35.609  -11.223 -0.739  1.00 55.44  ? 78  LEU L CD2 1 
ATOM   7067 N N   . GLN E 5 85  ? 37.221  -10.354 2.821   1.00 67.19  ? 79  GLN L N   1 
ATOM   7068 C CA  . GLN E 5 85  ? 37.957  -11.451 3.427   1.00 65.17  ? 79  GLN L CA  1 
ATOM   7069 C C   . GLN E 5 85  ? 37.154  -12.741 3.319   1.00 59.42  ? 79  GLN L C   1 
ATOM   7070 O O   . GLN E 5 85  ? 35.989  -12.748 2.915   1.00 68.81  ? 79  GLN L O   1 
ATOM   7071 C CB  . GLN E 5 85  ? 38.288  -11.127 4.887   1.00 63.14  ? 79  GLN L CB  1 
ATOM   7072 C CG  . GLN E 5 85  ? 38.788  -9.701  5.084   1.00 63.98  ? 79  GLN L CG  1 
ATOM   7073 C CD  . GLN E 5 85  ? 39.585  -9.526  6.359   1.00 82.53  ? 79  GLN L CD  1 
ATOM   7074 O OE1 . GLN E 5 85  ? 39.432  -10.293 7.309   1.00 77.22  ? 79  GLN L OE1 1 
ATOM   7075 N NE2 . GLN E 5 85  ? 40.452  -8.518  6.383   1.00 89.14  ? 79  GLN L NE2 1 
ATOM   7076 N N   . ALA E 5 86  ? 37.806  -13.849 3.682   1.00 66.92  ? 80  ALA L N   1 
ATOM   7077 C CA  . ALA E 5 86  ? 37.180  -15.159 3.528   1.00 68.26  ? 80  ALA L CA  1 
ATOM   7078 C C   . ALA E 5 86  ? 35.965  -15.315 4.437   1.00 61.43  ? 80  ALA L C   1 
ATOM   7079 O O   . ALA E 5 86  ? 34.964  -15.924 4.040   1.00 63.40  ? 80  ALA L O   1 
ATOM   7080 C CB  . ALA E 5 86  ? 38.203  -16.262 3.797   1.00 56.79  ? 80  ALA L CB  1 
ATOM   7081 N N   . GLU E 5 87  ? 36.033  -14.769 5.657   1.00 60.00  ? 81  GLU L N   1 
ATOM   7082 C CA  . GLU E 5 87  ? 34.965  -14.883 6.648   1.00 63.41  ? 81  GLU L CA  1 
ATOM   7083 C C   . GLU E 5 87  ? 33.726  -14.075 6.287   1.00 64.24  ? 81  GLU L C   1 
ATOM   7084 O O   . GLU E 5 87  ? 32.700  -14.212 6.963   1.00 58.30  ? 81  GLU L O   1 
ATOM   7085 C CB  . GLU E 5 87  ? 35.471  -14.457 8.037   1.00 58.09  ? 81  GLU L CB  1 
ATOM   7086 C CG  . GLU E 5 87  ? 36.401  -13.234 8.086   1.00 66.67  ? 81  GLU L CG  1 
ATOM   7087 C CD  . GLU E 5 87  ? 37.830  -13.548 7.661   1.00 90.95  ? 81  GLU L CD  1 
ATOM   7088 O OE1 . GLU E 5 87  ? 38.040  -13.813 6.458   1.00 90.83  ? 81  GLU L OE1 1 
ATOM   7089 O OE2 . GLU E 5 87  ? 38.738  -13.534 8.523   1.00 94.89  ? 81  GLU L OE2 1 
ATOM   7090 N N   . ASP E 5 88  ? 33.797  -13.241 5.254   1.00 64.61  ? 82  ASP L N   1 
ATOM   7091 C CA  . ASP E 5 88  ? 32.682  -12.405 4.837   1.00 56.06  ? 82  ASP L CA  1 
ATOM   7092 C C   . ASP E 5 88  ? 31.737  -13.108 3.873   1.00 50.93  ? 82  ASP L C   1 
ATOM   7093 O O   . ASP E 5 88  ? 30.772  -12.487 3.414   1.00 55.14  ? 82  ASP L O   1 
ATOM   7094 C CB  . ASP E 5 88  ? 33.206  -11.116 4.193   1.00 53.64  ? 82  ASP L CB  1 
ATOM   7095 C CG  . ASP E 5 88  ? 34.024  -10.268 5.156   1.00 67.03  ? 82  ASP L CG  1 
ATOM   7096 O OD1 . ASP E 5 88  ? 33.783  -10.346 6.380   1.00 68.60  ? 82  ASP L OD1 1 
ATOM   7097 O OD2 . ASP E 5 88  ? 34.905  -9.516  4.685   1.00 66.88  ? 82  ASP L OD2 1 
ATOM   7098 N N   . VAL E 5 89  ? 31.987  -14.374 3.547   1.00 40.28  ? 83  VAL L N   1 
ATOM   7099 C CA  . VAL E 5 89  ? 31.097  -15.120 2.660   1.00 54.06  ? 83  VAL L CA  1 
ATOM   7100 C C   . VAL E 5 89  ? 29.769  -15.321 3.382   1.00 52.11  ? 83  VAL L C   1 
ATOM   7101 O O   . VAL E 5 89  ? 29.706  -16.013 4.403   1.00 50.80  ? 83  VAL L O   1 
ATOM   7102 C CB  . VAL E 5 89  ? 31.708  -16.462 2.243   1.00 50.73  ? 83  VAL L CB  1 
ATOM   7103 C CG1 . VAL E 5 89  ? 30.724  -17.251 1.394   1.00 40.48  ? 83  VAL L CG1 1 
ATOM   7104 C CG2 . VAL E 5 89  ? 32.995  -16.235 1.487   1.00 55.75  ? 83  VAL L CG2 1 
ATOM   7105 N N   . ALA E 5 90  ? 28.707  -14.722 2.854   1.00 38.95  ? 84  ALA L N   1 
ATOM   7106 C CA  . ALA E 5 90  ? 27.383  -14.805 3.461   1.00 42.14  ? 84  ALA L CA  1 
ATOM   7107 C C   . ALA E 5 90  ? 26.369  -14.260 2.464   1.00 44.06  ? 84  ALA L C   1 
ATOM   7108 O O   . ALA E 5 90  ? 26.707  -13.906 1.330   1.00 41.43  ? 84  ALA L O   1 
ATOM   7109 C CB  . ALA E 5 90  ? 27.324  -14.041 4.784   1.00 37.30  ? 84  ALA L CB  1 
ATOM   7110 N N   . VAL E 5 91  ? 25.114  -14.206 2.899   1.00 45.89  ? 85  VAL L N   1 
ATOM   7111 C CA  . VAL E 5 91  ? 24.038  -13.548 2.169   1.00 51.55  ? 85  VAL L CA  1 
ATOM   7112 C C   . VAL E 5 91  ? 23.697  -12.271 2.924   1.00 46.20  ? 85  VAL L C   1 
ATOM   7113 O O   . VAL E 5 91  ? 23.505  -12.300 4.146   1.00 39.24  ? 85  VAL L O   1 
ATOM   7114 C CB  . VAL E 5 91  ? 22.809  -14.463 2.023   1.00 46.02  ? 85  VAL L CB  1 
ATOM   7115 C CG1 . VAL E 5 91  ? 21.671  -13.732 1.332   1.00 36.92  ? 85  VAL L CG1 1 
ATOM   7116 C CG2 . VAL E 5 91  ? 23.176  -15.722 1.252   1.00 37.85  ? 85  VAL L CG2 1 
ATOM   7117 N N   . TYR E 5 92  ? 23.652  -11.151 2.206   1.00 47.31  ? 86  TYR L N   1 
ATOM   7118 C CA  . TYR E 5 92  ? 23.428  -9.839  2.801   1.00 48.84  ? 86  TYR L CA  1 
ATOM   7119 C C   . TYR E 5 92  ? 22.040  -9.333  2.435   1.00 42.55  ? 86  TYR L C   1 
ATOM   7120 O O   . TYR E 5 92  ? 21.635  -9.405  1.270   1.00 51.13  ? 86  TYR L O   1 
ATOM   7121 C CB  . TYR E 5 92  ? 24.501  -8.843  2.346   1.00 47.28  ? 86  TYR L CB  1 
ATOM   7122 C CG  . TYR E 5 92  ? 25.880  -9.192  2.859   1.00 45.70  ? 86  TYR L CG  1 
ATOM   7123 C CD1 . TYR E 5 92  ? 26.691  -10.085 2.172   1.00 41.69  ? 86  TYR L CD1 1 
ATOM   7124 C CD2 . TYR E 5 92  ? 26.361  -8.647  4.044   1.00 37.61  ? 86  TYR L CD2 1 
ATOM   7125 C CE1 . TYR E 5 92  ? 27.946  -10.419 2.643   1.00 38.97  ? 86  TYR L CE1 1 
ATOM   7126 C CE2 . TYR E 5 92  ? 27.617  -8.975  4.522   1.00 39.96  ? 86  TYR L CE2 1 
ATOM   7127 C CZ  . TYR E 5 92  ? 28.404  -9.862  3.817   1.00 44.18  ? 86  TYR L CZ  1 
ATOM   7128 O OH  . TYR E 5 92  ? 29.654  -10.195 4.285   1.00 51.94  ? 86  TYR L OH  1 
ATOM   7129 N N   . TYR E 5 93  ? 21.313  -8.834  3.435   1.00 39.53  ? 87  TYR L N   1 
ATOM   7130 C CA  . TYR E 5 93  ? 19.979  -8.279  3.254   1.00 53.38  ? 87  TYR L CA  1 
ATOM   7131 C C   . TYR E 5 93  ? 19.961  -6.814  3.669   1.00 48.12  ? 87  TYR L C   1 
ATOM   7132 O O   . TYR E 5 93  ? 20.668  -6.407  4.597   1.00 42.24  ? 87  TYR L O   1 
ATOM   7133 C CB  . TYR E 5 93  ? 18.929  -9.040  4.083   1.00 47.40  ? 87  TYR L CB  1 
ATOM   7134 C CG  . TYR E 5 93  ? 18.768  -10.506 3.746   1.00 48.82  ? 87  TYR L CG  1 
ATOM   7135 C CD1 . TYR E 5 93  ? 19.538  -11.472 4.378   1.00 41.77  ? 87  TYR L CD1 1 
ATOM   7136 C CD2 . TYR E 5 93  ? 17.825  -10.926 2.815   1.00 47.82  ? 87  TYR L CD2 1 
ATOM   7137 C CE1 . TYR E 5 93  ? 19.386  -12.815 4.081   1.00 45.09  ? 87  TYR L CE1 1 
ATOM   7138 C CE2 . TYR E 5 93  ? 17.666  -12.264 2.512   1.00 45.03  ? 87  TYR L CE2 1 
ATOM   7139 C CZ  . TYR E 5 93  ? 18.448  -13.205 3.148   1.00 46.83  ? 87  TYR L CZ  1 
ATOM   7140 O OH  . TYR E 5 93  ? 18.293  -14.539 2.849   1.00 45.70  ? 87  TYR L OH  1 
ATOM   7141 N N   . CYS E 5 94  ? 19.143  -6.021  2.981   1.00 47.82  ? 88  CYS L N   1 
ATOM   7142 C CA  . CYS E 5 94  ? 18.818  -4.669  3.417   1.00 48.75  ? 88  CYS L CA  1 
ATOM   7143 C C   . CYS E 5 94  ? 17.374  -4.653  3.894   1.00 50.48  ? 88  CYS L C   1 
ATOM   7144 O O   . CYS E 5 94  ? 16.477  -5.135  3.194   1.00 58.66  ? 88  CYS L O   1 
ATOM   7145 C CB  . CYS E 5 94  ? 19.036  -3.631  2.307   1.00 44.95  ? 88  CYS L CB  1 
ATOM   7146 S SG  . CYS E 5 94  ? 18.183  -3.911  0.728   1.00 70.22  ? 88  CYS L SG  1 
ATOM   7147 N N   . GLN E 5 95  ? 17.156  -4.115  5.089   1.00 44.22  ? 89  GLN L N   1 
ATOM   7148 C CA  . GLN E 5 95  ? 15.851  -4.126  5.727   1.00 39.14  ? 89  GLN L CA  1 
ATOM   7149 C C   . GLN E 5 95  ? 15.420  -2.704  6.052   1.00 43.54  ? 89  GLN L C   1 
ATOM   7150 O O   . GLN E 5 95  ? 16.231  -1.883  6.491   1.00 42.41  ? 89  GLN L O   1 
ATOM   7151 C CB  . GLN E 5 95  ? 15.875  -4.971  7.002   1.00 41.18  ? 89  GLN L CB  1 
ATOM   7152 C CG  . GLN E 5 95  ? 14.555  -5.013  7.748   1.00 48.05  ? 89  GLN L CG  1 
ATOM   7153 C CD  . GLN E 5 95  ? 14.672  -4.473  9.157   1.00 49.60  ? 89  GLN L CD  1 
ATOM   7154 O OE1 . GLN E 5 95  ? 15.709  -3.933  9.541   1.00 49.95  ? 89  GLN L OE1 1 
ATOM   7155 N NE2 . GLN E 5 95  ? 13.607  -4.619  9.937   1.00 51.23  ? 89  GLN L NE2 1 
ATOM   7156 N N   . GLN E 5 96  ? 14.140  -2.422  5.828   1.00 46.85  ? 90  GLN L N   1 
ATOM   7157 C CA  . GLN E 5 96  ? 13.543  -1.137  6.164   1.00 42.20  ? 90  GLN L CA  1 
ATOM   7158 C C   . GLN E 5 96  ? 12.714  -1.278  7.434   1.00 47.63  ? 90  GLN L C   1 
ATOM   7159 O O   . GLN E 5 96  ? 11.903  -2.203  7.554   1.00 46.05  ? 90  GLN L O   1 
ATOM   7160 C CB  . GLN E 5 96  ? 12.675  -0.620  5.014   1.00 41.36  ? 90  GLN L CB  1 
ATOM   7161 C CG  . GLN E 5 96  ? 11.531  0.297   5.435   1.00 37.81  ? 90  GLN L CG  1 
ATOM   7162 C CD  . GLN E 5 96  ? 10.243  -0.458  5.723   1.00 38.87  ? 90  GLN L CD  1 
ATOM   7163 O OE1 . GLN E 5 96  ? 10.082  -1.613  5.327   1.00 41.45  ? 90  GLN L OE1 1 
ATOM   7164 N NE2 . GLN E 5 96  ? 9.324   0.191   6.424   1.00 47.39  ? 90  GLN L NE2 1 
ATOM   7165 N N   . TYR E 5 97  ? 12.926  -0.363  8.376   1.00 44.43  ? 91  TYR L N   1 
ATOM   7166 C CA  . TYR E 5 97  ? 12.131  -0.277  9.594   1.00 34.10  ? 91  TYR L CA  1 
ATOM   7167 C C   . TYR E 5 97  ? 11.541  1.117   9.755   1.00 38.47  ? 91  TYR L C   1 
ATOM   7168 O O   . TYR E 5 97  ? 11.325  1.589   10.873  1.00 37.65  ? 91  TYR L O   1 
ATOM   7169 C CB  . TYR E 5 97  ? 12.959  -0.664  10.817  1.00 39.75  ? 91  TYR L CB  1 
ATOM   7170 C CG  . TYR E 5 97  ? 14.293  0.046   10.950  1.00 46.84  ? 91  TYR L CG  1 
ATOM   7171 C CD1 . TYR E 5 97  ? 15.410  -0.385  10.243  1.00 45.53  ? 91  TYR L CD1 1 
ATOM   7172 C CD2 . TYR E 5 97  ? 14.445  1.125   11.812  1.00 46.85  ? 91  TYR L CD2 1 
ATOM   7173 C CE1 . TYR E 5 97  ? 16.635  0.254   10.375  1.00 52.82  ? 91  TYR L CE1 1 
ATOM   7174 C CE2 . TYR E 5 97  ? 15.666  1.768   11.950  1.00 40.39  ? 91  TYR L CE2 1 
ATOM   7175 C CZ  . TYR E 5 97  ? 16.756  1.329   11.232  1.00 45.57  ? 91  TYR L CZ  1 
ATOM   7176 O OH  . TYR E 5 97  ? 17.968  1.970   11.375  1.00 42.43  ? 91  TYR L OH  1 
ATOM   7177 N N   . TYR E 5 98  ? 11.296  1.790   8.630   1.00 45.60  ? 92  TYR L N   1 
ATOM   7178 C CA  . TYR E 5 98  ? 10.699  3.119   8.661   1.00 51.62  ? 92  TYR L CA  1 
ATOM   7179 C C   . TYR E 5 98  ? 9.226   3.052   9.042   1.00 48.54  ? 92  TYR L C   1 
ATOM   7180 O O   . TYR E 5 98  ? 8.725   3.919   9.769   1.00 54.37  ? 92  TYR L O   1 
ATOM   7181 C CB  . TYR E 5 98  ? 10.882  3.791   7.299   1.00 62.02  ? 92  TYR L CB  1 
ATOM   7182 C CG  . TYR E 5 98  ? 10.159  5.108   7.126   1.00 62.85  ? 92  TYR L CG  1 
ATOM   7183 C CD1 . TYR E 5 98  ? 10.742  6.301   7.531   1.00 57.61  ? 92  TYR L CD1 1 
ATOM   7184 C CD2 . TYR E 5 98  ? 8.903   5.161   6.532   1.00 52.80  ? 92  TYR L CD2 1 
ATOM   7185 C CE1 . TYR E 5 98  ? 10.090  7.508   7.365   1.00 60.71  ? 92  TYR L CE1 1 
ATOM   7186 C CE2 . TYR E 5 98  ? 8.243   6.363   6.362   1.00 50.97  ? 92  TYR L CE2 1 
ATOM   7187 C CZ  . TYR E 5 98  ? 8.842   7.534   6.780   1.00 59.18  ? 92  TYR L CZ  1 
ATOM   7188 O OH  . TYR E 5 98  ? 8.191   8.735   6.614   1.00 57.16  ? 92  TYR L OH  1 
ATOM   7189 N N   . SER E 5 99  ? 8.518   2.033   8.563   1.00 42.15  ? 93  SER L N   1 
ATOM   7190 C CA  . SER E 5 99  ? 7.093   1.893   8.822   1.00 55.70  ? 93  SER L CA  1 
ATOM   7191 C C   . SER E 5 99  ? 6.708   0.423   8.754   1.00 55.15  ? 93  SER L C   1 
ATOM   7192 O O   . SER E 5 99  ? 7.204   -0.319  7.901   1.00 51.79  ? 93  SER L O   1 
ATOM   7193 C CB  . SER E 5 99  ? 6.265   2.702   7.819   1.00 63.94  ? 93  SER L CB  1 
ATOM   7194 O OG  . SER E 5 99  ? 6.521   2.278   6.490   1.00 52.12  ? 93  SER L OG  1 
ATOM   7195 N N   . THR E 5 100 ? 5.818   0.013   9.654   1.00 52.15  ? 94  THR L N   1 
ATOM   7196 C CA  . THR E 5 100 ? 5.330   -1.355  9.653   1.00 53.34  ? 94  THR L CA  1 
ATOM   7197 C C   . THR E 5 100 ? 4.465   -1.609  8.416   1.00 52.50  ? 94  THR L C   1 
ATOM   7198 O O   . THR E 5 100 ? 3.763   -0.712  7.944   1.00 62.00  ? 94  THR L O   1 
ATOM   7199 C CB  . THR E 5 100 ? 4.529   -1.633  10.924  1.00 51.82  ? 94  THR L CB  1 
ATOM   7200 O OG1 . THR E 5 100 ? 3.521   -0.627  11.091  1.00 66.60  ? 94  THR L OG1 1 
ATOM   7201 C CG2 . THR E 5 100 ? 5.444   -1.618  12.135  1.00 44.80  ? 94  THR L CG2 1 
ATOM   7202 N N   . PRO E 5 101 ? 4.511   -2.826  7.856   1.00 54.47  ? 95  PRO L N   1 
ATOM   7203 C CA  . PRO E 5 101 ? 5.323   -3.982  8.261   1.00 55.77  ? 95  PRO L CA  1 
ATOM   7204 C C   . PRO E 5 101 ? 6.774   -3.859  7.811   1.00 49.46  ? 95  PRO L C   1 
ATOM   7205 O O   . PRO E 5 101 ? 7.058   -3.261  6.773   1.00 47.94  ? 95  PRO L O   1 
ATOM   7206 C CB  . PRO E 5 101 ? 4.608   -5.150  7.570   1.00 47.61  ? 95  PRO L CB  1 
ATOM   7207 C CG  . PRO E 5 101 ? 4.095   -4.543  6.300   1.00 39.42  ? 95  PRO L CG  1 
ATOM   7208 C CD  . PRO E 5 101 ? 3.694   -3.129  6.667   1.00 49.14  ? 95  PRO L CD  1 
ATOM   7209 N N   . TYR E 5 102 ? 7.711   -4.409  8.580   1.00 51.66  ? 96  TYR L N   1 
ATOM   7210 C CA  . TYR E 5 102 ? 9.104   -4.434  8.157   1.00 53.12  ? 96  TYR L CA  1 
ATOM   7211 C C   . TYR E 5 102 ? 9.247   -5.296  6.911   1.00 47.67  ? 96  TYR L C   1 
ATOM   7212 O O   . TYR E 5 102 ? 8.557   -6.306  6.751   1.00 48.76  ? 96  TYR L O   1 
ATOM   7213 C CB  . TYR E 5 102 ? 10.003  -4.976  9.270   1.00 44.79  ? 96  TYR L CB  1 
ATOM   7214 C CG  . TYR E 5 102 ? 10.041  -4.139  10.530  1.00 43.51  ? 96  TYR L CG  1 
ATOM   7215 C CD1 . TYR E 5 102 ? 9.622   -2.815  10.527  1.00 51.00  ? 96  TYR L CD1 1 
ATOM   7216 C CD2 . TYR E 5 102 ? 10.508  -4.675  11.724  1.00 45.81  ? 96  TYR L CD2 1 
ATOM   7217 C CE1 . TYR E 5 102 ? 9.661   -2.049  11.685  1.00 52.47  ? 96  TYR L CE1 1 
ATOM   7218 C CE2 . TYR E 5 102 ? 10.551  -3.921  12.881  1.00 33.83  ? 96  TYR L CE2 1 
ATOM   7219 C CZ  . TYR E 5 102 ? 10.128  -2.611  12.858  1.00 44.35  ? 96  TYR L CZ  1 
ATOM   7220 O OH  . TYR E 5 102 ? 10.173  -1.867  14.015  1.00 46.58  ? 96  TYR L OH  1 
ATOM   7221 N N   . THR E 5 103 ? 10.140  -4.888  6.018   1.00 35.44  ? 97  THR L N   1 
ATOM   7222 C CA  . THR E 5 103 ? 10.373  -5.610  4.779   1.00 38.70  ? 97  THR L CA  1 
ATOM   7223 C C   . THR E 5 103 ? 11.869  -5.771  4.558   1.00 43.36  ? 97  THR L C   1 
ATOM   7224 O O   . THR E 5 103 ? 12.670  -4.934  4.982   1.00 40.52  ? 97  THR L O   1 
ATOM   7225 C CB  . THR E 5 103 ? 9.735   -4.895  3.581   1.00 37.81  ? 97  THR L CB  1 
ATOM   7226 O OG1 . THR E 5 103 ? 10.166  -3.529  3.552   1.00 50.27  ? 97  THR L OG1 1 
ATOM   7227 C CG2 . THR E 5 103 ? 8.218   -4.936  3.681   1.00 28.98  ? 97  THR L CG2 1 
ATOM   7228 N N   . PHE E 5 104 ? 12.234  -6.866  3.897   1.00 46.62  ? 98  PHE L N   1 
ATOM   7229 C CA  . PHE E 5 104 ? 13.614  -7.182  3.568   1.00 41.28  ? 98  PHE L CA  1 
ATOM   7230 C C   . PHE E 5 104 ? 13.790  -7.207  2.055   1.00 45.16  ? 98  PHE L C   1 
ATOM   7231 O O   . PHE E 5 104 ? 12.821  -7.300  1.296   1.00 47.26  ? 98  PHE L O   1 
ATOM   7232 C CB  . PHE E 5 104 ? 14.034  -8.543  4.149   1.00 35.34  ? 98  PHE L CB  1 
ATOM   7233 C CG  . PHE E 5 104 ? 14.133  -8.568  5.645   1.00 30.97  ? 98  PHE L CG  1 
ATOM   7234 C CD1 . PHE E 5 104 ? 13.006  -8.755  6.425   1.00 36.05  ? 98  PHE L CD1 1 
ATOM   7235 C CD2 . PHE E 5 104 ? 15.359  -8.420  6.273   1.00 43.04  ? 98  PHE L CD2 1 
ATOM   7236 C CE1 . PHE E 5 104 ? 13.098  -8.784  7.806   1.00 40.23  ? 98  PHE L CE1 1 
ATOM   7237 C CE2 . PHE E 5 104 ? 15.458  -8.449  7.650   1.00 38.18  ? 98  PHE L CE2 1 
ATOM   7238 C CZ  . PHE E 5 104 ? 14.324  -8.630  8.419   1.00 30.91  ? 98  PHE L CZ  1 
ATOM   7239 N N   . GLY E 5 105 ? 15.048  -7.119  1.621   1.00 52.28  ? 99  GLY L N   1 
ATOM   7240 C CA  . GLY E 5 105 ? 15.375  -7.384  0.238   1.00 32.83  ? 99  GLY L CA  1 
ATOM   7241 C C   . GLY E 5 105 ? 15.451  -8.874  -0.036  1.00 41.00  ? 99  GLY L C   1 
ATOM   7242 O O   . GLY E 5 105 ? 15.372  -9.708  0.866   1.00 47.74  ? 99  GLY L O   1 
ATOM   7243 N N   . GLN E 5 106 ? 15.607  -9.215  -1.317  1.00 45.72  ? 100 GLN L N   1 
ATOM   7244 C CA  . GLN E 5 106 ? 15.665  -10.625 -1.688  1.00 49.46  ? 100 GLN L CA  1 
ATOM   7245 C C   . GLN E 5 106 ? 16.982  -11.283 -1.297  1.00 48.91  ? 100 GLN L C   1 
ATOM   7246 O O   . GLN E 5 106 ? 17.076  -12.515 -1.339  1.00 58.95  ? 100 GLN L O   1 
ATOM   7247 C CB  . GLN E 5 106 ? 15.429  -10.793 -3.192  1.00 43.50  ? 100 GLN L CB  1 
ATOM   7248 C CG  . GLN E 5 106 ? 16.603  -10.390 -4.068  1.00 39.42  ? 100 GLN L CG  1 
ATOM   7249 C CD  . GLN E 5 106 ? 16.660  -8.899  -4.328  1.00 49.45  ? 100 GLN L CD  1 
ATOM   7250 O OE1 . GLN E 5 106 ? 16.025  -8.105  -3.633  1.00 52.02  ? 100 GLN L OE1 1 
ATOM   7251 N NE2 . GLN E 5 106 ? 17.421  -8.510  -5.343  1.00 45.20  ? 100 GLN L NE2 1 
ATOM   7252 N N   . GLY E 5 107 ? 17.982  -10.506 -0.923  1.00 49.20  ? 101 GLY L N   1 
ATOM   7253 C CA  . GLY E 5 107 ? 19.263  -11.036 -0.507  1.00 46.14  ? 101 GLY L CA  1 
ATOM   7254 C C   . GLY E 5 107 ? 20.272  -11.044 -1.640  1.00 44.27  ? 101 GLY L C   1 
ATOM   7255 O O   . GLY E 5 107 ? 19.935  -11.241 -2.813  1.00 45.46  ? 101 GLY L O   1 
ATOM   7256 N N   . THR E 5 108 ? 21.535  -10.829 -1.284  1.00 48.69  ? 102 THR L N   1 
ATOM   7257 C CA  . THR E 5 108 ? 22.642  -10.853 -2.230  1.00 46.92  ? 102 THR L CA  1 
ATOM   7258 C C   . THR E 5 108 ? 23.667  -11.868 -1.750  1.00 38.96  ? 102 THR L C   1 
ATOM   7259 O O   . THR E 5 108 ? 24.136  -11.788 -0.609  1.00 43.00  ? 102 THR L O   1 
ATOM   7260 C CB  . THR E 5 108 ? 23.281  -9.470  -2.370  1.00 44.12  ? 102 THR L CB  1 
ATOM   7261 O OG1 . THR E 5 108 ? 22.322  -8.548  -2.902  1.00 44.55  ? 102 THR L OG1 1 
ATOM   7262 C CG2 . THR E 5 108 ? 24.485  -9.533  -3.293  1.00 38.26  ? 102 THR L CG2 1 
ATOM   7263 N N   . LYS E 5 109 ? 24.009  -12.820 -2.615  1.00 43.75  ? 103 LYS L N   1 
ATOM   7264 C CA  . LYS E 5 109 ? 24.987  -13.849 -2.293  1.00 52.02  ? 103 LYS L CA  1 
ATOM   7265 C C   . LYS E 5 109 ? 26.385  -13.345 -2.627  1.00 52.75  ? 103 LYS L C   1 
ATOM   7266 O O   . LYS E 5 109 ? 26.625  -12.845 -3.731  1.00 50.97  ? 103 LYS L O   1 
ATOM   7267 C CB  . LYS E 5 109 ? 24.684  -15.138 -3.061  1.00 57.01  ? 103 LYS L CB  1 
ATOM   7268 C CG  . LYS E 5 109 ? 25.630  -16.288 -2.754  1.00 57.74  ? 103 LYS L CG  1 
ATOM   7269 C CD  . LYS E 5 109 ? 25.629  -16.607 -1.269  1.00 65.62  ? 103 LYS L CD  1 
ATOM   7270 C CE  . LYS E 5 109 ? 26.582  -17.742 -0.934  1.00 62.28  ? 103 LYS L CE  1 
ATOM   7271 N NZ  . LYS E 5 109 ? 26.564  -18.048 0.524   1.00 58.47  ? 103 LYS L NZ  1 
ATOM   7272 N N   . VAL E 5 110 ? 27.301  -13.467 -1.669  1.00 48.93  ? 104 VAL L N   1 
ATOM   7273 C CA  . VAL E 5 110 ? 28.675  -13.005 -1.822  1.00 55.26  ? 104 VAL L CA  1 
ATOM   7274 C C   . VAL E 5 110 ? 29.601  -14.202 -1.667  1.00 57.22  ? 104 VAL L C   1 
ATOM   7275 O O   . VAL E 5 110 ? 29.538  -14.918 -0.661  1.00 56.93  ? 104 VAL L O   1 
ATOM   7276 C CB  . VAL E 5 110 ? 29.025  -11.904 -0.806  1.00 51.18  ? 104 VAL L CB  1 
ATOM   7277 C CG1 . VAL E 5 110 ? 30.495  -11.531 -0.909  1.00 42.99  ? 104 VAL L CG1 1 
ATOM   7278 C CG2 . VAL E 5 110 ? 28.155  -10.681 -1.039  1.00 47.58  ? 104 VAL L CG2 1 
ATOM   7279 N N   . GLU E 5 111 ? 30.457  -14.416 -2.663  1.00 56.76  ? 105 GLU L N   1 
ATOM   7280 C CA  . GLU E 5 111 ? 31.383  -15.535 -2.678  1.00 47.96  ? 105 GLU L CA  1 
ATOM   7281 C C   . GLU E 5 111 ? 32.786  -15.026 -2.977  1.00 54.82  ? 105 GLU L C   1 
ATOM   7282 O O   . GLU E 5 111 ? 32.970  -13.963 -3.575  1.00 56.22  ? 105 GLU L O   1 
ATOM   7283 C CB  . GLU E 5 111 ? 30.977  -16.585 -3.722  1.00 38.49  ? 105 GLU L CB  1 
ATOM   7284 C CG  . GLU E 5 111 ? 31.149  -16.108 -5.159  1.00 51.27  ? 105 GLU L CG  1 
ATOM   7285 C CD  . GLU E 5 111 ? 30.945  -17.210 -6.185  1.00 66.60  ? 105 GLU L CD  1 
ATOM   7286 O OE1 . GLU E 5 111 ? 30.116  -18.114 -5.945  1.00 59.15  ? 105 GLU L OE1 1 
ATOM   7287 O OE2 . GLU E 5 111 ? 31.621  -17.171 -7.235  1.00 68.60  ? 105 GLU L OE2 1 
ATOM   7288 N N   . ILE E 5 112 ? 33.777  -15.804 -2.551  1.00 55.98  ? 106 ILE L N   1 
ATOM   7289 C CA  . ILE E 5 112 ? 35.172  -15.509 -2.860  1.00 50.73  ? 106 ILE L CA  1 
ATOM   7290 C C   . ILE E 5 112 ? 35.452  -15.919 -4.298  1.00 46.82  ? 106 ILE L C   1 
ATOM   7291 O O   . ILE E 5 112 ? 35.163  -17.053 -4.698  1.00 50.69  ? 106 ILE L O   1 
ATOM   7292 C CB  . ILE E 5 112 ? 36.113  -16.240 -1.890  1.00 59.95  ? 106 ILE L CB  1 
ATOM   7293 C CG1 . ILE E 5 112 ? 35.862  -15.802 -0.447  1.00 53.86  ? 106 ILE L CG1 1 
ATOM   7294 C CG2 . ILE E 5 112 ? 37.567  -16.010 -2.285  1.00 64.22  ? 106 ILE L CG2 1 
ATOM   7295 C CD1 . ILE E 5 112 ? 36.598  -14.553 -0.043  1.00 57.60  ? 106 ILE L CD1 1 
ATOM   7296 N N   . LYS E 5 113 ? 36.019  -15.002 -5.077  1.00 51.84  ? 107 LYS L N   1 
ATOM   7297 C CA  . LYS E 5 113 ? 36.434  -15.319 -6.436  1.00 54.80  ? 107 LYS L CA  1 
ATOM   7298 C C   . LYS E 5 113 ? 37.824  -15.943 -6.421  1.00 57.05  ? 107 LYS L C   1 
ATOM   7299 O O   . LYS E 5 113 ? 38.737  -15.437 -5.761  1.00 58.20  ? 107 LYS L O   1 
ATOM   7300 C CB  . LYS E 5 113 ? 36.428  -14.065 -7.311  1.00 56.18  ? 107 LYS L CB  1 
ATOM   7301 C CG  . LYS E 5 113 ? 36.501  -14.350 -8.806  1.00 51.08  ? 107 LYS L CG  1 
ATOM   7302 C CD  . LYS E 5 113 ? 36.942  -13.120 -9.586  1.00 61.87  ? 107 LYS L CD  1 
ATOM   7303 C CE  . LYS E 5 113 ? 36.100  -11.904 -9.231  1.00 73.67  ? 107 LYS L CE  1 
ATOM   7304 N NZ  . LYS E 5 113 ? 36.480  -10.711 -10.039 1.00 76.12  ? 107 LYS L NZ  1 
ATOM   7305 N N   . ARG E 5 114 ? 37.978  -17.044 -7.148  1.00 52.84  ? 108 ARG L N   1 
ATOM   7306 C CA  . ARG E 5 114 ? 39.251  -17.731 -7.304  1.00 45.55  ? 108 ARG L CA  1 
ATOM   7307 C C   . ARG E 5 114 ? 39.488  -17.970 -8.789  1.00 48.42  ? 108 ARG L C   1 
ATOM   7308 O O   . ARG E 5 114 ? 38.640  -17.664 -9.632  1.00 45.33  ? 108 ARG L O   1 
ATOM   7309 C CB  . ARG E 5 114 ? 39.265  -19.058 -6.536  1.00 49.16  ? 108 ARG L CB  1 
ATOM   7310 C CG  . ARG E 5 114 ? 38.454  -20.141 -7.224  1.00 49.10  ? 108 ARG L CG  1 
ATOM   7311 C CD  . ARG E 5 114 ? 38.437  -21.459 -6.463  1.00 49.59  ? 108 ARG L CD  1 
ATOM   7312 N NE  . ARG E 5 114 ? 39.741  -21.883 -5.964  1.00 50.48  ? 108 ARG L NE  1 
ATOM   7313 C CZ  . ARG E 5 114 ? 40.748  -22.301 -6.720  1.00 44.20  ? 108 ARG L CZ  1 
ATOM   7314 N NH1 . ARG E 5 114 ? 40.696  -22.242 -8.041  1.00 48.75  ? 108 ARG L NH1 1 
ATOM   7315 N NH2 . ARG E 5 114 ? 41.836  -22.793 -6.135  1.00 66.08  ? 108 ARG L NH2 1 
ATOM   7316 N N   . THR E 5 115 ? 40.650  -18.528 -9.112  1.00 50.22  ? 109 THR L N   1 
ATOM   7317 C CA  . THR E 5 115 ? 40.917  -18.910 -10.489 1.00 54.60  ? 109 THR L CA  1 
ATOM   7318 C C   . THR E 5 115 ? 40.056  -20.112 -10.873 1.00 49.48  ? 109 THR L C   1 
ATOM   7319 O O   . THR E 5 115 ? 39.702  -20.944 -10.033 1.00 36.31  ? 109 THR L O   1 
ATOM   7320 C CB  . THR E 5 115 ? 42.404  -19.216 -10.684 1.00 52.53  ? 109 THR L CB  1 
ATOM   7321 O OG1 . THR E 5 115 ? 42.633  -19.678 -12.022 1.00 64.37  ? 109 THR L OG1 1 
ATOM   7322 C CG2 . THR E 5 115 ? 42.885  -20.263 -9.679  1.00 55.80  ? 109 THR L CG2 1 
ATOM   7323 N N   . VAL E 5 116 ? 39.704  -20.183 -12.159 1.00 49.76  ? 110 VAL L N   1 
ATOM   7324 C CA  . VAL E 5 116 ? 38.815  -21.235 -12.644 1.00 36.13  ? 110 VAL L CA  1 
ATOM   7325 C C   . VAL E 5 116 ? 39.467  -22.591 -12.419 1.00 49.32  ? 110 VAL L C   1 
ATOM   7326 O O   . VAL E 5 116 ? 40.578  -22.854 -12.898 1.00 58.58  ? 110 VAL L O   1 
ATOM   7327 C CB  . VAL E 5 116 ? 38.479  -21.017 -14.122 1.00 37.30  ? 110 VAL L CB  1 
ATOM   7328 C CG1 . VAL E 5 116 ? 37.604  -22.148 -14.633 1.00 47.76  ? 110 VAL L CG1 1 
ATOM   7329 C CG2 . VAL E 5 116 ? 37.791  -19.678 -14.312 1.00 44.79  ? 110 VAL L CG2 1 
ATOM   7330 N N   . ALA E 5 117 ? 38.775  -23.461 -11.685 1.00 45.12  ? 111 ALA L N   1 
ATOM   7331 C CA  . ALA E 5 117 ? 39.249  -24.804 -11.372 1.00 43.78  ? 111 ALA L CA  1 
ATOM   7332 C C   . ALA E 5 117 ? 38.284  -25.819 -11.963 1.00 38.91  ? 111 ALA L C   1 
ATOM   7333 O O   . ALA E 5 117 ? 37.090  -25.801 -11.645 1.00 49.26  ? 111 ALA L O   1 
ATOM   7334 C CB  . ALA E 5 117 ? 39.374  -25.003 -9.861  1.00 39.49  ? 111 ALA L CB  1 
ATOM   7335 N N   . ALA E 5 118 ? 38.799  -26.703 -12.813 1.00 36.45  ? 112 ALA L N   1 
ATOM   7336 C CA  . ALA E 5 118 ? 37.958  -27.721 -13.419 1.00 39.19  ? 112 ALA L CA  1 
ATOM   7337 C C   . ALA E 5 118 ? 37.549  -28.765 -12.378 1.00 44.10  ? 112 ALA L C   1 
ATOM   7338 O O   . ALA E 5 118 ? 38.300  -29.051 -11.443 1.00 52.63  ? 112 ALA L O   1 
ATOM   7339 C CB  . ALA E 5 118 ? 38.682  -28.396 -14.579 1.00 36.75  ? 112 ALA L CB  1 
ATOM   7340 N N   . PRO E 5 119 ? 36.354  -29.336 -12.511 1.00 50.77  ? 113 PRO L N   1 
ATOM   7341 C CA  . PRO E 5 119 ? 35.923  -30.368 -11.565 1.00 41.74  ? 113 PRO L CA  1 
ATOM   7342 C C   . PRO E 5 119 ? 36.681  -31.669 -11.762 1.00 49.05  ? 113 PRO L C   1 
ATOM   7343 O O   . PRO E 5 119 ? 37.132  -31.998 -12.860 1.00 47.24  ? 113 PRO L O   1 
ATOM   7344 C CB  . PRO E 5 119 ? 34.436  -30.543 -11.891 1.00 34.44  ? 113 PRO L CB  1 
ATOM   7345 C CG  . PRO E 5 119 ? 34.343  -30.188 -13.336 1.00 40.07  ? 113 PRO L CG  1 
ATOM   7346 C CD  . PRO E 5 119 ? 35.329  -29.066 -13.535 1.00 60.20  ? 113 PRO L CD  1 
ATOM   7347 N N   . SER E 5 120 ? 36.817  -32.413 -10.667 1.00 54.42  ? 114 SER L N   1 
ATOM   7348 C CA  . SER E 5 120 ? 37.264  -33.799 -10.706 1.00 45.72  ? 114 SER L CA  1 
ATOM   7349 C C   . SER E 5 120 ? 36.008  -34.661 -10.696 1.00 43.72  ? 114 SER L C   1 
ATOM   7350 O O   . SER E 5 120 ? 35.232  -34.625 -9.734  1.00 41.37  ? 114 SER L O   1 
ATOM   7351 C CB  . SER E 5 120 ? 38.177  -34.126 -9.524  1.00 43.56  ? 114 SER L CB  1 
ATOM   7352 O OG  . SER E 5 120 ? 39.297  -33.257 -9.476  1.00 50.49  ? 114 SER L OG  1 
ATOM   7353 N N   . VAL E 5 121 ? 35.800  -35.420 -11.768 1.00 39.94  ? 115 VAL L N   1 
ATOM   7354 C CA  . VAL E 5 121 ? 34.570  -36.176 -11.967 1.00 40.31  ? 115 VAL L CA  1 
ATOM   7355 C C   . VAL E 5 121 ? 34.818  -37.625 -11.579 1.00 38.81  ? 115 VAL L C   1 
ATOM   7356 O O   . VAL E 5 121 ? 35.743  -38.267 -12.091 1.00 43.61  ? 115 VAL L O   1 
ATOM   7357 C CB  . VAL E 5 121 ? 34.073  -36.072 -13.416 1.00 37.62  ? 115 VAL L CB  1 
ATOM   7358 C CG1 . VAL E 5 121 ? 32.764  -36.826 -13.576 1.00 39.37  ? 115 VAL L CG1 1 
ATOM   7359 C CG2 . VAL E 5 121 ? 33.898  -34.619 -13.809 1.00 41.73  ? 115 VAL L CG2 1 
ATOM   7360 N N   . PHE E 5 122 ? 33.989  -38.139 -10.676 1.00 44.19  ? 116 PHE L N   1 
ATOM   7361 C CA  . PHE E 5 122 ? 34.035  -39.530 -10.258 1.00 44.27  ? 116 PHE L CA  1 
ATOM   7362 C C   . PHE E 5 122 ? 32.640  -40.124 -10.379 1.00 47.97  ? 116 PHE L C   1 
ATOM   7363 O O   . PHE E 5 122 ? 31.637  -39.437 -10.166 1.00 51.30  ? 116 PHE L O   1 
ATOM   7364 C CB  . PHE E 5 122 ? 34.545  -39.672 -8.818  1.00 41.39  ? 116 PHE L CB  1 
ATOM   7365 C CG  . PHE E 5 122 ? 35.839  -38.955 -8.559  1.00 50.72  ? 116 PHE L CG  1 
ATOM   7366 C CD1 . PHE E 5 122 ? 37.033  -39.449 -9.058  1.00 52.70  ? 116 PHE L CD1 1 
ATOM   7367 C CD2 . PHE E 5 122 ? 35.862  -37.790 -7.810  1.00 44.93  ? 116 PHE L CD2 1 
ATOM   7368 C CE1 . PHE E 5 122 ? 38.225  -38.793 -8.821  1.00 47.16  ? 116 PHE L CE1 1 
ATOM   7369 C CE2 . PHE E 5 122 ? 37.053  -37.128 -7.569  1.00 44.34  ? 116 PHE L CE2 1 
ATOM   7370 C CZ  . PHE E 5 122 ? 38.235  -37.631 -8.075  1.00 49.85  ? 116 PHE L CZ  1 
ATOM   7371 N N   . ILE E 5 123 ? 32.580  -41.405 -10.728 1.00 48.53  ? 117 ILE L N   1 
ATOM   7372 C CA  . ILE E 5 123 ? 31.316  -42.093 -10.954 1.00 51.20  ? 117 ILE L CA  1 
ATOM   7373 C C   . ILE E 5 123 ? 31.285  -43.348 -10.092 1.00 50.12  ? 117 ILE L C   1 
ATOM   7374 O O   . ILE E 5 123 ? 32.270  -44.094 -10.034 1.00 46.00  ? 117 ILE L O   1 
ATOM   7375 C CB  . ILE E 5 123 ? 31.113  -42.429 -12.446 1.00 43.14  ? 117 ILE L CB  1 
ATOM   7376 C CG1 . ILE E 5 123 ? 29.855  -43.271 -12.652 1.00 52.80  ? 117 ILE L CG1 1 
ATOM   7377 C CG2 . ILE E 5 123 ? 32.347  -43.110 -13.029 1.00 54.18  ? 117 ILE L CG2 1 
ATOM   7378 C CD1 . ILE E 5 123 ? 29.653  -43.691 -14.087 1.00 69.40  ? 117 ILE L CD1 1 
ATOM   7379 N N   . PHE E 5 124 ? 30.167  -43.568 -9.405  1.00 51.97  ? 118 PHE L N   1 
ATOM   7380 C CA  . PHE E 5 124 ? 30.013  -44.705 -8.508  1.00 36.94  ? 118 PHE L CA  1 
ATOM   7381 C C   . PHE E 5 124 ? 28.868  -45.584 -8.985  1.00 47.83  ? 118 PHE L C   1 
ATOM   7382 O O   . PHE E 5 124 ? 27.712  -45.127 -9.002  1.00 51.12  ? 118 PHE L O   1 
ATOM   7383 C CB  . PHE E 5 124 ? 29.759  -44.235 -7.076  1.00 26.41  ? 118 PHE L CB  1 
ATOM   7384 C CG  . PHE E 5 124 ? 30.854  -43.382 -6.529  1.00 40.50  ? 118 PHE L CG  1 
ATOM   7385 C CD1 . PHE E 5 124 ? 31.984  -43.958 -5.978  1.00 44.39  ? 118 PHE L CD1 1 
ATOM   7386 C CD2 . PHE E 5 124 ? 30.761  -42.002 -6.575  1.00 43.69  ? 118 PHE L CD2 1 
ATOM   7387 C CE1 . PHE E 5 124 ? 33.002  -43.174 -5.477  1.00 39.29  ? 118 PHE L CE1 1 
ATOM   7388 C CE2 . PHE E 5 124 ? 31.775  -41.211 -6.075  1.00 42.62  ? 118 PHE L CE2 1 
ATOM   7389 C CZ  . PHE E 5 124 ? 32.897  -41.799 -5.526  1.00 40.01  ? 118 PHE L CZ  1 
ATOM   7390 N N   . PRO E 5 125 ? 29.124  -46.829 -9.397  1.00 48.15  ? 119 PRO L N   1 
ATOM   7391 C CA  . PRO E 5 125 ? 28.015  -47.733 -9.695  1.00 38.69  ? 119 PRO L CA  1 
ATOM   7392 C C   . PRO E 5 125 ? 27.281  -48.114 -8.424  1.00 42.72  ? 119 PRO L C   1 
ATOM   7393 O O   . PRO E 5 125 ? 27.842  -48.024 -7.320  1.00 46.39  ? 119 PRO L O   1 
ATOM   7394 C CB  . PRO E 5 125 ? 28.710  -48.950 -10.331 1.00 34.48  ? 119 PRO L CB  1 
ATOM   7395 C CG  . PRO E 5 125 ? 30.089  -48.913 -9.782  1.00 49.61  ? 119 PRO L CG  1 
ATOM   7396 C CD  . PRO E 5 125 ? 30.437  -47.462 -9.628  1.00 44.31  ? 119 PRO L CD  1 
ATOM   7397 N N   . PRO E 5 126 ? 26.011  -48.514 -8.521  1.00 53.31  ? 120 PRO L N   1 
ATOM   7398 C CA  . PRO E 5 126 ? 25.266  -48.888 -7.314  1.00 48.43  ? 120 PRO L CA  1 
ATOM   7399 C C   . PRO E 5 126 ? 25.887  -50.094 -6.627  1.00 42.49  ? 120 PRO L C   1 
ATOM   7400 O O   . PRO E 5 126 ? 26.434  -50.993 -7.270  1.00 44.71  ? 120 PRO L O   1 
ATOM   7401 C CB  . PRO E 5 126 ? 23.864  -49.206 -7.845  1.00 41.20  ? 120 PRO L CB  1 
ATOM   7402 C CG  . PRO E 5 126 ? 24.075  -49.551 -9.273  1.00 41.50  ? 120 PRO L CG  1 
ATOM   7403 C CD  . PRO E 5 126 ? 25.201  -48.679 -9.741  1.00 43.39  ? 120 PRO L CD  1 
ATOM   7404 N N   . SER E 5 127 ? 25.805  -50.100 -5.297  1.00 43.08  ? 121 SER L N   1 
ATOM   7405 C CA  . SER E 5 127 ? 26.363  -51.189 -4.514  1.00 46.50  ? 121 SER L CA  1 
ATOM   7406 C C   . SER E 5 127 ? 25.534  -52.457 -4.677  1.00 53.98  ? 121 SER L C   1 
ATOM   7407 O O   . SER E 5 127 ? 24.332  -52.413 -4.949  1.00 54.44  ? 121 SER L O   1 
ATOM   7408 C CB  . SER E 5 127 ? 26.436  -50.807 -3.033  1.00 46.76  ? 121 SER L CB  1 
ATOM   7409 O OG  . SER E 5 127 ? 25.144  -50.580 -2.496  1.00 39.25  ? 121 SER L OG  1 
ATOM   7410 N N   . ASP E 5 128 ? 26.197  -53.604 -4.502  1.00 69.29  ? 122 ASP L N   1 
ATOM   7411 C CA  . ASP E 5 128 ? 25.487  -54.878 -4.550  1.00 63.85  ? 122 ASP L CA  1 
ATOM   7412 C C   . ASP E 5 128 ? 24.441  -54.977 -3.447  1.00 54.99  ? 122 ASP L C   1 
ATOM   7413 O O   . ASP E 5 128 ? 23.416  -55.643 -3.625  1.00 53.05  ? 122 ASP L O   1 
ATOM   7414 C CB  . ASP E 5 128 ? 26.479  -56.036 -4.455  1.00 56.50  ? 122 ASP L CB  1 
ATOM   7415 C CG  . ASP E 5 128 ? 26.953  -56.507 -5.817  1.00 78.85  ? 122 ASP L CG  1 
ATOM   7416 O OD1 . ASP E 5 128 ? 26.118  -57.021 -6.592  1.00 76.07  ? 122 ASP L OD1 1 
ATOM   7417 O OD2 . ASP E 5 128 ? 28.155  -56.349 -6.118  1.00 86.19  ? 122 ASP L OD2 1 
ATOM   7418 N N   . GLU E 5 129 ? 24.678  -54.323 -2.308  1.00 52.23  ? 123 GLU L N   1 
ATOM   7419 C CA  . GLU E 5 129 ? 23.683  -54.320 -1.241  1.00 55.82  ? 123 GLU L CA  1 
ATOM   7420 C C   . GLU E 5 129 ? 22.406  -53.607 -1.671  1.00 52.59  ? 123 GLU L C   1 
ATOM   7421 O O   . GLU E 5 129 ? 21.298  -54.099 -1.423  1.00 48.83  ? 123 GLU L O   1 
ATOM   7422 C CB  . GLU E 5 129 ? 24.260  -53.668 0.014   1.00 56.94  ? 123 GLU L CB  1 
ATOM   7423 C CG  . GLU E 5 129 ? 23.201  -53.027 0.892   1.00 68.92  ? 123 GLU L CG  1 
ATOM   7424 C CD  . GLU E 5 129 ? 23.711  -52.655 2.268   1.00 78.93  ? 123 GLU L CD  1 
ATOM   7425 O OE1 . GLU E 5 129 ? 22.892  -52.227 3.108   1.00 84.34  ? 123 GLU L OE1 1 
ATOM   7426 O OE2 . GLU E 5 129 ? 24.930  -52.784 2.512   1.00 77.88  ? 123 GLU L OE2 1 
ATOM   7427 N N   . GLN E 5 130 ? 22.540  -52.449 -2.319  1.00 52.56  ? 124 GLN L N   1 
ATOM   7428 C CA  . GLN E 5 130 ? 21.360  -51.684 -2.707  1.00 53.70  ? 124 GLN L CA  1 
ATOM   7429 C C   . GLN E 5 130 ? 20.545  -52.404 -3.773  1.00 54.13  ? 124 GLN L C   1 
ATOM   7430 O O   . GLN E 5 130 ? 19.313  -52.300 -3.783  1.00 55.50  ? 124 GLN L O   1 
ATOM   7431 C CB  . GLN E 5 130 ? 21.773  -50.298 -3.200  1.00 53.19  ? 124 GLN L CB  1 
ATOM   7432 C CG  . GLN E 5 130 ? 20.600  -49.365 -3.456  1.00 44.47  ? 124 GLN L CG  1 
ATOM   7433 C CD  . GLN E 5 130 ? 20.999  -48.125 -4.232  1.00 51.04  ? 124 GLN L CD  1 
ATOM   7434 O OE1 . GLN E 5 130 ? 20.152  -47.311 -4.598  1.00 45.76  ? 124 GLN L OE1 1 
ATOM   7435 N NE2 . GLN E 5 130 ? 22.294  -47.974 -4.484  1.00 45.28  ? 124 GLN L NE2 1 
ATOM   7436 N N   . LEU E 5 131 ? 21.207  -53.138 -4.670  1.00 47.76  ? 125 LEU L N   1 
ATOM   7437 C CA  . LEU E 5 131 ? 20.484  -53.853 -5.716  1.00 54.75  ? 125 LEU L CA  1 
ATOM   7438 C C   . LEU E 5 131 ? 19.549  -54.900 -5.125  1.00 65.16  ? 125 LEU L C   1 
ATOM   7439 O O   . LEU E 5 131 ? 18.437  -55.102 -5.627  1.00 63.28  ? 125 LEU L O   1 
ATOM   7440 C CB  . LEU E 5 131 ? 21.471  -54.496 -6.688  1.00 53.74  ? 125 LEU L CB  1 
ATOM   7441 C CG  . LEU E 5 131 ? 22.249  -53.506 -7.554  1.00 57.53  ? 125 LEU L CG  1 
ATOM   7442 C CD1 . LEU E 5 131 ? 23.416  -54.195 -8.241  1.00 56.28  ? 125 LEU L CD1 1 
ATOM   7443 C CD2 . LEU E 5 131 ? 21.321  -52.859 -8.573  1.00 48.33  ? 125 LEU L CD2 1 
ATOM   7444 N N   . LYS E 5 132 ? 19.978  -55.568 -4.051  1.00 64.35  ? 126 LYS L N   1 
ATOM   7445 C CA  . LYS E 5 132 ? 19.142  -56.586 -3.424  1.00 55.47  ? 126 LYS L CA  1 
ATOM   7446 C C   . LYS E 5 132 ? 17.846  -56.008 -2.866  1.00 58.31  ? 126 LYS L C   1 
ATOM   7447 O O   . LYS E 5 132 ? 16.865  -56.745 -2.720  1.00 58.18  ? 126 LYS L O   1 
ATOM   7448 C CB  . LYS E 5 132 ? 19.921  -57.297 -2.312  1.00 55.36  ? 126 LYS L CB  1 
ATOM   7449 C CG  . LYS E 5 132 ? 21.264  -57.879 -2.752  1.00 76.26  ? 126 LYS L CG  1 
ATOM   7450 C CD  . LYS E 5 132 ? 21.602  -59.148 -1.971  1.00 75.45  ? 126 LYS L CD  1 
ATOM   7451 C CE  . LYS E 5 132 ? 22.953  -59.054 -1.268  1.00 79.46  ? 126 LYS L CE  1 
ATOM   7452 N NZ  . LYS E 5 132 ? 24.106  -59.124 -2.210  1.00 68.12  ? 126 LYS L NZ  1 
ATOM   7453 N N   . SER E 5 133 ? 17.816  -54.711 -2.555  1.00 56.09  ? 127 SER L N   1 
ATOM   7454 C CA  . SER E 5 133 ? 16.600  -54.073 -2.067  1.00 46.36  ? 127 SER L CA  1 
ATOM   7455 C C   . SER E 5 133 ? 15.659  -53.650 -3.188  1.00 54.62  ? 127 SER L C   1 
ATOM   7456 O O   . SER E 5 133 ? 14.541  -53.209 -2.901  1.00 60.08  ? 127 SER L O   1 
ATOM   7457 C CB  . SER E 5 133 ? 16.953  -52.857 -1.205  1.00 50.62  ? 127 SER L CB  1 
ATOM   7458 O OG  . SER E 5 133 ? 17.708  -51.911 -1.941  1.00 63.24  ? 127 SER L OG  1 
ATOM   7459 N N   . GLY E 5 134 ? 16.078  -53.765 -4.447  1.00 52.04  ? 128 GLY L N   1 
ATOM   7460 C CA  . GLY E 5 134 ? 15.214  -53.482 -5.573  1.00 56.58  ? 128 GLY L CA  1 
ATOM   7461 C C   . GLY E 5 134 ? 15.400  -52.131 -6.229  1.00 59.45  ? 128 GLY L C   1 
ATOM   7462 O O   . GLY E 5 134 ? 14.655  -51.811 -7.164  1.00 63.32  ? 128 GLY L O   1 
ATOM   7463 N N   . THR E 5 135 ? 16.360  -51.328 -5.779  1.00 56.60  ? 129 THR L N   1 
ATOM   7464 C CA  . THR E 5 135 ? 16.626  -50.027 -6.376  1.00 55.33  ? 129 THR L CA  1 
ATOM   7465 C C   . THR E 5 135 ? 18.114  -49.891 -6.665  1.00 43.43  ? 129 THR L C   1 
ATOM   7466 O O   . THR E 5 135 ? 18.951  -50.499 -5.994  1.00 58.22  ? 129 THR L O   1 
ATOM   7467 C CB  . THR E 5 135 ? 16.168  -48.877 -5.468  1.00 41.08  ? 129 THR L CB  1 
ATOM   7468 O OG1 . THR E 5 135 ? 16.715  -49.057 -4.156  1.00 68.60  ? 129 THR L OG1 1 
ATOM   7469 C CG2 . THR E 5 135 ? 14.651  -48.836 -5.381  1.00 39.46  ? 129 THR L CG2 1 
ATOM   7470 N N   . ALA E 5 136 ? 18.434  -49.091 -7.682  1.00 42.68  ? 130 ALA L N   1 
ATOM   7471 C CA  . ALA E 5 136 ? 19.813  -48.808 -8.060  1.00 49.68  ? 130 ALA L CA  1 
ATOM   7472 C C   . ALA E 5 136 ? 20.022  -47.303 -8.128  1.00 47.97  ? 130 ALA L C   1 
ATOM   7473 O O   . ALA E 5 136 ? 19.216  -46.589 -8.732  1.00 46.31  ? 130 ALA L O   1 
ATOM   7474 C CB  . ALA E 5 136 ? 20.165  -49.449 -9.405  1.00 40.74  ? 130 ALA L CB  1 
ATOM   7475 N N   . SER E 5 137 ? 21.097  -46.826 -7.504  1.00 45.36  ? 131 SER L N   1 
ATOM   7476 C CA  . SER E 5 137 ? 21.467  -45.416 -7.523  1.00 41.58  ? 131 SER L CA  1 
ATOM   7477 C C   . SER E 5 137 ? 22.874  -45.272 -8.083  1.00 40.90  ? 131 SER L C   1 
ATOM   7478 O O   . SER E 5 137 ? 23.805  -45.934 -7.613  1.00 46.71  ? 131 SER L O   1 
ATOM   7479 C CB  . SER E 5 137 ? 21.394  -44.798 -6.121  1.00 43.59  ? 131 SER L CB  1 
ATOM   7480 O OG  . SER E 5 137 ? 20.060  -44.735 -5.645  1.00 43.42  ? 131 SER L OG  1 
ATOM   7481 N N   . VAL E 5 138 ? 23.026  -44.410 -9.084  1.00 40.17  ? 132 VAL L N   1 
ATOM   7482 C CA  . VAL E 5 138 ? 24.321  -44.091 -9.673  1.00 39.84  ? 132 VAL L CA  1 
ATOM   7483 C C   . VAL E 5 138 ? 24.667  -42.668 -9.264  1.00 39.35  ? 132 VAL L C   1 
ATOM   7484 O O   . VAL E 5 138 ? 23.900  -41.735 -9.533  1.00 48.62  ? 132 VAL L O   1 
ATOM   7485 C CB  . VAL E 5 138 ? 24.303  -44.238 -11.202 1.00 38.29  ? 132 VAL L CB  1 
ATOM   7486 C CG1 . VAL E 5 138 ? 25.717  -44.140 -11.762 1.00 42.90  ? 132 VAL L CG1 1 
ATOM   7487 C CG2 . VAL E 5 138 ? 23.642  -45.548 -11.602 1.00 34.10  ? 132 VAL L CG2 1 
ATOM   7488 N N   . VAL E 5 139 ? 25.813  -42.495 -8.613  1.00 37.05  ? 133 VAL L N   1 
ATOM   7489 C CA  . VAL E 5 139 ? 26.224  -41.203 -8.078  1.00 39.76  ? 133 VAL L CA  1 
ATOM   7490 C C   . VAL E 5 139 ? 27.380  -40.674 -8.912  1.00 33.19  ? 133 VAL L C   1 
ATOM   7491 O O   . VAL E 5 139 ? 28.379  -41.374 -9.120  1.00 38.07  ? 133 VAL L O   1 
ATOM   7492 C CB  . VAL E 5 139 ? 26.620  -41.299 -6.594  1.00 39.98  ? 133 VAL L CB  1 
ATOM   7493 C CG1 . VAL E 5 139 ? 26.982  -39.922 -6.064  1.00 32.61  ? 133 VAL L CG1 1 
ATOM   7494 C CG2 . VAL E 5 139 ? 25.490  -41.907 -5.777  1.00 37.71  ? 133 VAL L CG2 1 
ATOM   7495 N N   . CYS E 5 140 ? 27.240  -39.442 -9.390  1.00 40.74  ? 134 CYS L N   1 
ATOM   7496 C CA  . CYS E 5 140 ? 28.291  -38.742 -10.112 1.00 44.65  ? 134 CYS L CA  1 
ATOM   7497 C C   . CYS E 5 140 ? 28.771  -37.577 -9.260  1.00 45.93  ? 134 CYS L C   1 
ATOM   7498 O O   . CYS E 5 140 ? 27.966  -36.740 -8.839  1.00 53.07  ? 134 CYS L O   1 
ATOM   7499 C CB  . CYS E 5 140 ? 27.784  -38.242 -11.465 1.00 38.23  ? 134 CYS L CB  1 
ATOM   7500 S SG  . CYS E 5 140 ? 29.083  -37.772 -12.624 1.00 68.21  ? 134 CYS L SG  1 
ATOM   7501 N N   . LEU E 5 141 ? 30.075  -37.525 -9.004  1.00 35.82  ? 135 LEU L N   1 
ATOM   7502 C CA  . LEU E 5 141 ? 30.659  -36.539 -8.104  1.00 40.23  ? 135 LEU L CA  1 
ATOM   7503 C C   . LEU E 5 141 ? 31.504  -35.543 -8.888  1.00 44.79  ? 135 LEU L C   1 
ATOM   7504 O O   . LEU E 5 141 ? 32.410  -35.938 -9.629  1.00 39.27  ? 135 LEU L O   1 
ATOM   7505 C CB  . LEU E 5 141 ? 31.512  -37.220 -7.032  1.00 41.57  ? 135 LEU L CB  1 
ATOM   7506 C CG  . LEU E 5 141 ? 32.390  -36.311 -6.168  1.00 44.13  ? 135 LEU L CG  1 
ATOM   7507 C CD1 . LEU E 5 141 ? 31.550  -35.337 -5.356  1.00 40.29  ? 135 LEU L CD1 1 
ATOM   7508 C CD2 . LEU E 5 141 ? 33.276  -37.143 -5.258  1.00 42.47  ? 135 LEU L CD2 1 
ATOM   7509 N N   . LEU E 5 142 ? 31.204  -34.256 -8.716  1.00 39.45  ? 136 LEU L N   1 
ATOM   7510 C CA  . LEU E 5 142 ? 32.015  -33.162 -9.242  1.00 42.15  ? 136 LEU L CA  1 
ATOM   7511 C C   . LEU E 5 142 ? 32.708  -32.516 -8.050  1.00 39.78  ? 136 LEU L C   1 
ATOM   7512 O O   . LEU E 5 142 ? 32.044  -31.941 -7.181  1.00 41.09  ? 136 LEU L O   1 
ATOM   7513 C CB  . LEU E 5 142 ? 31.163  -32.147 -10.002 1.00 38.28  ? 136 LEU L CB  1 
ATOM   7514 C CG  . LEU E 5 142 ? 30.648  -32.477 -11.409 1.00 37.58  ? 136 LEU L CG  1 
ATOM   7515 C CD1 . LEU E 5 142 ? 29.674  -33.652 -11.427 1.00 37.86  ? 136 LEU L CD1 1 
ATOM   7516 C CD2 . LEU E 5 142 ? 30.000  -31.244 -12.019 1.00 47.66  ? 136 LEU L CD2 1 
ATOM   7517 N N   . ASN E 5 143 ? 34.034  -32.608 -8.004  1.00 33.98  ? 137 ASN L N   1 
ATOM   7518 C CA  . ASN E 5 143 ? 34.784  -32.280 -6.801  1.00 44.64  ? 137 ASN L CA  1 
ATOM   7519 C C   . ASN E 5 143 ? 35.751  -31.132 -7.056  1.00 43.61  ? 137 ASN L C   1 
ATOM   7520 O O   . ASN E 5 143 ? 36.533  -31.172 -8.012  1.00 31.46  ? 137 ASN L O   1 
ATOM   7521 C CB  . ASN E 5 143 ? 35.541  -33.507 -6.291  1.00 29.01  ? 137 ASN L CB  1 
ATOM   7522 C CG  . ASN E 5 143 ? 35.846  -33.419 -4.818  1.00 42.88  ? 137 ASN L CG  1 
ATOM   7523 O OD1 . ASN E 5 143 ? 34.976  -33.653 -3.980  1.00 59.33  ? 137 ASN L OD1 1 
ATOM   7524 N ND2 . ASN E 5 143 ? 37.082  -33.069 -4.489  1.00 55.01  ? 137 ASN L ND2 1 
ATOM   7525 N N   . ASN E 5 144 ? 35.692  -30.117 -6.190  1.00 41.60  ? 138 ASN L N   1 
ATOM   7526 C CA  . ASN E 5 144 ? 36.654  -29.013 -6.143  1.00 40.49  ? 138 ASN L CA  1 
ATOM   7527 C C   . ASN E 5 144 ? 36.726  -28.274 -7.483  1.00 48.39  ? 138 ASN L C   1 
ATOM   7528 O O   . ASN E 5 144 ? 37.746  -28.270 -8.177  1.00 54.50  ? 138 ASN L O   1 
ATOM   7529 C CB  . ASN E 5 144 ? 38.041  -29.512 -5.723  1.00 44.20  ? 138 ASN L CB  1 
ATOM   7530 C CG  . ASN E 5 144 ? 38.128  -29.814 -4.241  1.00 47.38  ? 138 ASN L CG  1 
ATOM   7531 O OD1 . ASN E 5 144 ? 37.160  -30.264 -3.627  1.00 47.66  ? 138 ASN L OD1 1 
ATOM   7532 N ND2 . ASN E 5 144 ? 39.291  -29.560 -3.656  1.00 70.48  ? 138 ASN L ND2 1 
ATOM   7533 N N   . PHE E 5 145 ? 35.607  -27.640 -7.824  1.00 45.83  ? 139 PHE L N   1 
ATOM   7534 C CA  . PHE E 5 145 ? 35.510  -26.851 -9.041  1.00 36.03  ? 139 PHE L CA  1 
ATOM   7535 C C   . PHE E 5 145 ? 35.036  -25.444 -8.712  1.00 41.48  ? 139 PHE L C   1 
ATOM   7536 O O   . PHE E 5 145 ? 34.422  -25.195 -7.671  1.00 38.64  ? 139 PHE L O   1 
ATOM   7537 C CB  . PHE E 5 145 ? 34.571  -27.496 -10.077 1.00 43.64  ? 139 PHE L CB  1 
ATOM   7538 C CG  . PHE E 5 145 ? 33.135  -27.614 -9.630  1.00 42.53  ? 139 PHE L CG  1 
ATOM   7539 C CD1 . PHE E 5 145 ? 32.703  -28.719 -8.915  1.00 36.86  ? 139 PHE L CD1 1 
ATOM   7540 C CD2 . PHE E 5 145 ? 32.209  -26.635 -9.961  1.00 33.64  ? 139 PHE L CD2 1 
ATOM   7541 C CE1 . PHE E 5 145 ? 31.382  -28.835 -8.515  1.00 37.83  ? 139 PHE L CE1 1 
ATOM   7542 C CE2 . PHE E 5 145 ? 30.888  -26.745 -9.564  1.00 38.95  ? 139 PHE L CE2 1 
ATOM   7543 C CZ  . PHE E 5 145 ? 30.474  -27.846 -8.841  1.00 39.86  ? 139 PHE L CZ  1 
ATOM   7544 N N   . TYR E 5 146 ? 35.351  -24.520 -9.621  1.00 44.14  ? 140 TYR L N   1 
ATOM   7545 C CA  . TYR E 5 146 ? 34.920  -23.139 -9.549  1.00 37.77  ? 140 TYR L CA  1 
ATOM   7546 C C   . TYR E 5 146 ? 34.877  -22.621 -10.977 1.00 40.93  ? 140 TYR L C   1 
ATOM   7547 O O   . TYR E 5 146 ? 35.771  -22.950 -11.769 1.00 38.79  ? 140 TYR L O   1 
ATOM   7548 C CB  . TYR E 5 146 ? 35.857  -22.279 -8.699  1.00 28.63  ? 140 TYR L CB  1 
ATOM   7549 C CG  . TYR E 5 146 ? 35.368  -20.864 -8.501  1.00 47.00  ? 140 TYR L CG  1 
ATOM   7550 C CD1 . TYR E 5 146 ? 34.517  -20.542 -7.451  1.00 52.58  ? 140 TYR L CD1 1 
ATOM   7551 C CD2 . TYR E 5 146 ? 35.748  -19.850 -9.370  1.00 48.11  ? 140 TYR L CD2 1 
ATOM   7552 C CE1 . TYR E 5 146 ? 34.063  -19.248 -7.272  1.00 56.98  ? 140 TYR L CE1 1 
ATOM   7553 C CE2 . TYR E 5 146 ? 35.300  -18.558 -9.200  1.00 47.09  ? 140 TYR L CE2 1 
ATOM   7554 C CZ  . TYR E 5 146 ? 34.460  -18.260 -8.151  1.00 50.98  ? 140 TYR L CZ  1 
ATOM   7555 O OH  . TYR E 5 146 ? 34.017  -16.968 -7.986  1.00 54.24  ? 140 TYR L OH  1 
ATOM   7556 N N   . PRO E 5 147 ? 33.867  -21.824 -11.343 1.00 40.41  ? 141 PRO L N   1 
ATOM   7557 C CA  . PRO E 5 147 ? 32.747  -21.327 -10.528 1.00 40.09  ? 141 PRO L CA  1 
ATOM   7558 C C   . PRO E 5 147 ? 31.661  -22.374 -10.286 1.00 43.92  ? 141 PRO L C   1 
ATOM   7559 O O   . PRO E 5 147 ? 31.712  -23.478 -10.826 1.00 42.33  ? 141 PRO L O   1 
ATOM   7560 C CB  . PRO E 5 147 ? 32.232  -20.143 -11.356 1.00 52.57  ? 141 PRO L CB  1 
ATOM   7561 C CG  . PRO E 5 147 ? 32.509  -20.545 -12.772 1.00 42.88  ? 141 PRO L CG  1 
ATOM   7562 C CD  . PRO E 5 147 ? 33.813  -21.301 -12.721 1.00 49.51  ? 141 PRO L CD  1 
ATOM   7563 N N   . ARG E 5 148 ? 30.665  -22.025 -9.464  1.00 42.32  ? 142 ARG L N   1 
ATOM   7564 C CA  . ARG E 5 148 ? 29.639  -22.982 -9.056  1.00 36.94  ? 142 ARG L CA  1 
ATOM   7565 C C   . ARG E 5 148 ? 28.835  -23.509 -10.242 1.00 39.14  ? 142 ARG L C   1 
ATOM   7566 O O   . ARG E 5 148 ? 28.309  -24.627 -10.185 1.00 43.47  ? 142 ARG L O   1 
ATOM   7567 C CB  . ARG E 5 148 ? 28.711  -22.325 -8.031  1.00 35.27  ? 142 ARG L CB  1 
ATOM   7568 C CG  . ARG E 5 148 ? 27.593  -23.213 -7.500  1.00 43.93  ? 142 ARG L CG  1 
ATOM   7569 C CD  . ARG E 5 148 ? 26.469  -22.378 -6.895  1.00 45.40  ? 142 ARG L CD  1 
ATOM   7570 N NE  . ARG E 5 148 ? 26.387  -22.529 -5.448  1.00 53.48  ? 142 ARG L NE  1 
ATOM   7571 C CZ  . ARG E 5 148 ? 25.480  -23.266 -4.822  1.00 64.57  ? 142 ARG L CZ  1 
ATOM   7572 N NH1 . ARG E 5 148 ? 24.535  -23.911 -5.489  1.00 55.64  ? 142 ARG L NH1 1 
ATOM   7573 N NH2 . ARG E 5 148 ? 25.521  -23.358 -3.495  1.00 55.21  ? 142 ARG L NH2 1 
ATOM   7574 N N   . GLU E 5 149 ? 28.735  -22.737 -11.321 1.00 38.71  ? 143 GLU L N   1 
ATOM   7575 C CA  . GLU E 5 149 ? 27.874  -23.110 -12.438 1.00 37.01  ? 143 GLU L CA  1 
ATOM   7576 C C   . GLU E 5 149 ? 28.473  -24.288 -13.201 1.00 37.83  ? 143 GLU L C   1 
ATOM   7577 O O   . GLU E 5 149 ? 29.608  -24.216 -13.683 1.00 41.44  ? 143 GLU L O   1 
ATOM   7578 C CB  . GLU E 5 149 ? 27.663  -21.915 -13.367 1.00 45.07  ? 143 GLU L CB  1 
ATOM   7579 C CG  . GLU E 5 149 ? 27.122  -20.660 -12.676 1.00 66.24  ? 143 GLU L CG  1 
ATOM   7580 C CD  . GLU E 5 149 ? 28.211  -19.842 -12.002 1.00 74.64  ? 143 GLU L CD  1 
ATOM   7581 O OE1 . GLU E 5 149 ? 29.349  -19.835 -12.512 1.00 77.12  ? 143 GLU L OE1 1 
ATOM   7582 O OE2 . GLU E 5 149 ? 27.932  -19.210 -10.960 1.00 73.67  ? 143 GLU L OE2 1 
ATOM   7583 N N   . ALA E 5 150 ? 27.707  -25.372 -13.308 1.00 38.55  ? 144 ALA L N   1 
ATOM   7584 C CA  . ALA E 5 150 ? 28.117  -26.550 -14.060 1.00 31.61  ? 144 ALA L CA  1 
ATOM   7585 C C   . ALA E 5 150 ? 26.865  -27.293 -14.499 1.00 45.30  ? 144 ALA L C   1 
ATOM   7586 O O   . ALA E 5 150 ? 25.805  -27.176 -13.879 1.00 51.28  ? 144 ALA L O   1 
ATOM   7587 C CB  . ALA E 5 150 ? 29.032  -27.461 -13.235 1.00 23.61  ? 144 ALA L CB  1 
ATOM   7588 N N   . LYS E 5 151 ? 27.002  -28.064 -15.575 1.00 42.02  ? 145 LYS L N   1 
ATOM   7589 C CA  . LYS E 5 151 ? 25.903  -28.828 -16.148 1.00 40.75  ? 145 LYS L CA  1 
ATOM   7590 C C   . LYS E 5 151 ? 26.224  -30.312 -16.047 1.00 37.91  ? 145 LYS L C   1 
ATOM   7591 O O   . LYS E 5 151 ? 27.325  -30.735 -16.410 1.00 50.22  ? 145 LYS L O   1 
ATOM   7592 C CB  . LYS E 5 151 ? 25.658  -28.435 -17.610 1.00 40.62  ? 145 LYS L CB  1 
ATOM   7593 C CG  . LYS E 5 151 ? 24.553  -29.229 -18.283 1.00 47.15  ? 145 LYS L CG  1 
ATOM   7594 C CD  . LYS E 5 151 ? 24.594  -29.086 -19.794 1.00 42.91  ? 145 LYS L CD  1 
ATOM   7595 C CE  . LYS E 5 151 ? 24.301  -27.662 -20.217 1.00 53.18  ? 145 LYS L CE  1 
ATOM   7596 N NZ  . LYS E 5 151 ? 24.246  -27.541 -21.697 1.00 64.10  ? 145 LYS L NZ  1 
ATOM   7597 N N   . VAL E 5 152 ? 25.269  -31.096 -15.549 1.00 45.49  ? 146 VAL L N   1 
ATOM   7598 C CA  . VAL E 5 152 ? 25.404  -32.546 -15.450 1.00 42.57  ? 146 VAL L CA  1 
ATOM   7599 C C   . VAL E 5 152 ? 24.246  -33.189 -16.203 1.00 36.45  ? 146 VAL L C   1 
ATOM   7600 O O   . VAL E 5 152 ? 23.078  -32.886 -15.933 1.00 39.55  ? 146 VAL L O   1 
ATOM   7601 C CB  . VAL E 5 152 ? 25.439  -33.018 -13.983 1.00 36.31  ? 146 VAL L CB  1 
ATOM   7602 C CG1 . VAL E 5 152 ? 25.448  -34.533 -13.912 1.00 40.38  ? 146 VAL L CG1 1 
ATOM   7603 C CG2 . VAL E 5 152 ? 26.660  -32.456 -13.276 1.00 45.28  ? 146 VAL L CG2 1 
ATOM   7604 N N   . GLN E 5 153 ? 24.571  -34.070 -17.148 1.00 38.74  ? 147 GLN L N   1 
ATOM   7605 C CA  . GLN E 5 153 ? 23.582  -34.775 -17.953 1.00 36.83  ? 147 GLN L CA  1 
ATOM   7606 C C   . GLN E 5 153 ? 23.800  -36.274 -17.815 1.00 39.94  ? 147 GLN L C   1 
ATOM   7607 O O   . GLN E 5 153 ? 24.936  -36.750 -17.910 1.00 44.37  ? 147 GLN L O   1 
ATOM   7608 C CB  . GLN E 5 153 ? 23.668  -34.360 -19.424 1.00 35.09  ? 147 GLN L CB  1 
ATOM   7609 C CG  . GLN E 5 153 ? 23.408  -32.884 -19.661 1.00 51.90  ? 147 GLN L CG  1 
ATOM   7610 C CD  . GLN E 5 153 ? 23.853  -32.421 -21.034 1.00 62.59  ? 147 GLN L CD  1 
ATOM   7611 O OE1 . GLN E 5 153 ? 23.043  -31.958 -21.837 1.00 56.71  ? 147 GLN L OE1 1 
ATOM   7612 N NE2 . GLN E 5 153 ? 25.150  -32.529 -21.305 1.00 57.26  ? 147 GLN L NE2 1 
ATOM   7613 N N   . TRP E 5 154 ? 22.713  -37.009 -17.589 1.00 38.25  ? 148 TRP L N   1 
ATOM   7614 C CA  . TRP E 5 154 ? 22.749  -38.462 -17.481 1.00 37.19  ? 148 TRP L CA  1 
ATOM   7615 C C   . TRP E 5 154 ? 22.243  -39.072 -18.780 1.00 39.11  ? 148 TRP L C   1 
ATOM   7616 O O   . TRP E 5 154 ? 21.127  -38.774 -19.219 1.00 39.30  ? 148 TRP L O   1 
ATOM   7617 C CB  . TRP E 5 154 ? 21.896  -38.953 -16.312 1.00 38.81  ? 148 TRP L CB  1 
ATOM   7618 C CG  . TRP E 5 154 ? 22.500  -38.736 -14.966 1.00 40.40  ? 148 TRP L CG  1 
ATOM   7619 C CD1 . TRP E 5 154 ? 22.214  -37.730 -14.092 1.00 38.94  ? 148 TRP L CD1 1 
ATOM   7620 C CD2 . TRP E 5 154 ? 23.484  -39.556 -14.328 1.00 36.66  ? 148 TRP L CD2 1 
ATOM   7621 N NE1 . TRP E 5 154 ? 22.962  -37.869 -12.950 1.00 39.37  ? 148 TRP L NE1 1 
ATOM   7622 C CE2 . TRP E 5 154 ? 23.751  -38.983 -13.070 1.00 37.49  ? 148 TRP L CE2 1 
ATOM   7623 C CE3 . TRP E 5 154 ? 24.168  -40.718 -14.699 1.00 42.30  ? 148 TRP L CE3 1 
ATOM   7624 C CZ2 . TRP E 5 154 ? 24.671  -39.532 -12.180 1.00 41.50  ? 148 TRP L CZ2 1 
ATOM   7625 C CZ3 . TRP E 5 154 ? 25.083  -41.261 -13.815 1.00 43.46  ? 148 TRP L CZ3 1 
ATOM   7626 C CH2 . TRP E 5 154 ? 25.327  -40.667 -12.570 1.00 35.93  ? 148 TRP L CH2 1 
ATOM   7627 N N   . LYS E 5 155 ? 23.057  -39.932 -19.385 1.00 45.84  ? 149 LYS L N   1 
ATOM   7628 C CA  . LYS E 5 155 ? 22.677  -40.645 -20.596 1.00 40.45  ? 149 LYS L CA  1 
ATOM   7629 C C   . LYS E 5 155 ? 22.898  -42.131 -20.370 1.00 41.11  ? 149 LYS L C   1 
ATOM   7630 O O   . LYS E 5 155 ? 24.001  -42.549 -20.004 1.00 45.21  ? 149 LYS L O   1 
ATOM   7631 C CB  . LYS E 5 155 ? 23.467  -40.144 -21.810 1.00 36.19  ? 149 LYS L CB  1 
ATOM   7632 C CG  . LYS E 5 155 ? 22.974  -38.799 -22.322 1.00 53.09  ? 149 LYS L CG  1 
ATOM   7633 C CD  . LYS E 5 155 ? 23.541  -38.449 -23.689 1.00 45.56  ? 149 LYS L CD  1 
ATOM   7634 C CE  . LYS E 5 155 ? 24.923  -37.837 -23.581 1.00 47.25  ? 149 LYS L CE  1 
ATOM   7635 N NZ  . LYS E 5 155 ? 25.356  -37.240 -24.875 1.00 61.00  ? 149 LYS L NZ  1 
ATOM   7636 N N   . VAL E 5 156 ? 21.847  -42.919 -20.568 1.00 43.22  ? 150 VAL L N   1 
ATOM   7637 C CA  . VAL E 5 156 ? 21.900  -44.369 -20.430 1.00 46.11  ? 150 VAL L CA  1 
ATOM   7638 C C   . VAL E 5 156 ? 21.845  -44.965 -21.826 1.00 51.09  ? 150 VAL L C   1 
ATOM   7639 O O   . VAL E 5 156 ? 20.837  -44.819 -22.529 1.00 56.62  ? 150 VAL L O   1 
ATOM   7640 C CB  . VAL E 5 156 ? 20.751  -44.898 -19.560 1.00 45.75  ? 150 VAL L CB  1 
ATOM   7641 C CG1 . VAL E 5 156 ? 20.597  -46.388 -19.753 1.00 47.70  ? 150 VAL L CG1 1 
ATOM   7642 C CG2 . VAL E 5 156 ? 21.005  -44.573 -18.100 1.00 52.29  ? 150 VAL L CG2 1 
ATOM   7643 N N   . ASP E 5 157 ? 22.922  -45.644 -22.223 1.00 45.21  ? 151 ASP L N   1 
ATOM   7644 C CA  . ASP E 5 157 ? 23.067  -46.137 -23.591 1.00 49.45  ? 151 ASP L CA  1 
ATOM   7645 C C   . ASP E 5 157 ? 22.865  -45.001 -24.596 1.00 50.24  ? 151 ASP L C   1 
ATOM   7646 O O   . ASP E 5 157 ? 22.145  -45.135 -25.588 1.00 43.33  ? 151 ASP L O   1 
ATOM   7647 C CB  . ASP E 5 157 ? 22.107  -47.301 -23.864 1.00 46.63  ? 151 ASP L CB  1 
ATOM   7648 C CG  . ASP E 5 157 ? 22.452  -48.553 -23.061 1.00 53.53  ? 151 ASP L CG  1 
ATOM   7649 O OD1 . ASP E 5 157 ? 23.624  -48.700 -22.658 1.00 58.25  ? 151 ASP L OD1 1 
ATOM   7650 O OD2 . ASP E 5 157 ? 21.552  -49.395 -22.837 1.00 45.82  ? 151 ASP L OD2 1 
ATOM   7651 N N   . ASN E 5 158 ? 23.491  -43.856 -24.311 1.00 43.63  ? 152 ASN L N   1 
ATOM   7652 C CA  . ASN E 5 158 ? 23.416  -42.642 -25.127 1.00 51.51  ? 152 ASN L CA  1 
ATOM   7653 C C   . ASN E 5 158 ? 21.996  -42.082 -25.219 1.00 45.90  ? 152 ASN L C   1 
ATOM   7654 O O   . ASN E 5 158 ? 21.699  -41.278 -26.108 1.00 50.16  ? 152 ASN L O   1 
ATOM   7655 C CB  . ASN E 5 158 ? 23.991  -42.872 -26.533 1.00 43.77  ? 152 ASN L CB  1 
ATOM   7656 C CG  . ASN E 5 158 ? 24.485  -41.586 -27.184 1.00 55.83  ? 152 ASN L CG  1 
ATOM   7657 O OD1 . ASN E 5 158 ? 23.804  -40.998 -28.026 1.00 60.28  ? 152 ASN L OD1 1 
ATOM   7658 N ND2 . ASN E 5 158 ? 25.676  -41.145 -26.793 1.00 54.86  ? 152 ASN L ND2 1 
ATOM   7659 N N   . ALA E 5 159 ? 21.108  -42.478 -24.308 1.00 39.85  ? 153 ALA L N   1 
ATOM   7660 C CA  . ALA E 5 159 ? 19.748  -41.954 -24.246 1.00 31.66  ? 153 ALA L CA  1 
ATOM   7661 C C   . ALA E 5 159 ? 19.620  -41.049 -23.029 1.00 45.59  ? 153 ALA L C   1 
ATOM   7662 O O   . ALA E 5 159 ? 19.857  -41.487 -21.898 1.00 48.99  ? 153 ALA L O   1 
ATOM   7663 C CB  . ALA E 5 159 ? 18.720  -43.081 -24.182 1.00 35.35  ? 153 ALA L CB  1 
ATOM   7664 N N   . LEU E 5 160 ? 19.230  -39.797 -23.265 1.00 44.65  ? 154 LEU L N   1 
ATOM   7665 C CA  . LEU E 5 160 ? 19.168  -38.806 -22.199 1.00 31.73  ? 154 LEU L CA  1 
ATOM   7666 C C   . LEU E 5 160 ? 18.123  -39.189 -21.158 1.00 37.15  ? 154 LEU L C   1 
ATOM   7667 O O   . LEU E 5 160 ? 17.024  -39.642 -21.489 1.00 45.95  ? 154 LEU L O   1 
ATOM   7668 C CB  . LEU E 5 160 ? 18.853  -37.431 -22.785 1.00 30.78  ? 154 LEU L CB  1 
ATOM   7669 C CG  . LEU E 5 160 ? 18.861  -36.241 -21.828 1.00 36.07  ? 154 LEU L CG  1 
ATOM   7670 C CD1 . LEU E 5 160 ? 20.233  -36.088 -21.212 1.00 36.76  ? 154 LEU L CD1 1 
ATOM   7671 C CD2 . LEU E 5 160 ? 18.463  -34.976 -22.563 1.00 41.21  ? 154 LEU L CD2 1 
ATOM   7672 N N   . GLN E 5 161 ? 18.471  -38.996 -19.891 1.00 34.44  ? 155 GLN L N   1 
ATOM   7673 C CA  . GLN E 5 161 ? 17.603  -39.338 -18.774 1.00 36.77  ? 155 GLN L CA  1 
ATOM   7674 C C   . GLN E 5 161 ? 16.912  -38.089 -18.246 1.00 41.23  ? 155 GLN L C   1 
ATOM   7675 O O   . GLN E 5 161 ? 17.535  -37.033 -18.106 1.00 49.58  ? 155 GLN L O   1 
ATOM   7676 C CB  . GLN E 5 161 ? 18.401  -40.006 -17.656 1.00 44.98  ? 155 GLN L CB  1 
ATOM   7677 C CG  . GLN E 5 161 ? 19.009  -41.329 -18.065 1.00 45.78  ? 155 GLN L CG  1 
ATOM   7678 C CD  . GLN E 5 161 ? 17.954  -42.366 -18.366 1.00 41.90  ? 155 GLN L CD  1 
ATOM   7679 O OE1 . GLN E 5 161 ? 17.056  -42.603 -17.559 1.00 53.97  ? 155 GLN L OE1 1 
ATOM   7680 N NE2 . GLN E 5 161 ? 18.046  -42.983 -19.538 1.00 49.33  ? 155 GLN L NE2 1 
ATOM   7681 N N   . SER E 5 162 ? 15.620  -38.217 -17.955 1.00 34.39  ? 156 SER L N   1 
ATOM   7682 C CA  . SER E 5 162 ? 14.815  -37.097 -17.493 1.00 35.61  ? 156 SER L CA  1 
ATOM   7683 C C   . SER E 5 162 ? 13.939  -37.532 -16.329 1.00 42.85  ? 156 SER L C   1 
ATOM   7684 O O   . SER E 5 162 ? 13.333  -38.606 -16.365 1.00 47.39  ? 156 SER L O   1 
ATOM   7685 C CB  . SER E 5 162 ? 13.937  -36.542 -18.622 1.00 39.80  ? 156 SER L CB  1 
ATOM   7686 O OG  . SER E 5 162 ? 12.961  -35.650 -18.113 1.00 39.08  ? 156 SER L OG  1 
ATOM   7687 N N   . GLY E 5 163 ? 13.874  -36.689 -15.301 1.00 44.57  ? 157 GLY L N   1 
ATOM   7688 C CA  . GLY E 5 163 ? 12.951  -36.896 -14.202 1.00 40.80  ? 157 GLY L CA  1 
ATOM   7689 C C   . GLY E 5 163 ? 13.351  -37.939 -13.183 1.00 44.23  ? 157 GLY L C   1 
ATOM   7690 O O   . GLY E 5 163 ? 12.539  -38.266 -12.311 1.00 46.49  ? 157 GLY L O   1 
ATOM   7691 N N   . ASN E 5 164 ? 14.575  -38.471 -13.252 1.00 47.61  ? 158 ASN L N   1 
ATOM   7692 C CA  . ASN E 5 164 ? 15.024  -39.488 -12.307 1.00 32.62  ? 158 ASN L CA  1 
ATOM   7693 C C   . ASN E 5 164 ? 16.384  -39.150 -11.706 1.00 42.17  ? 158 ASN L C   1 
ATOM   7694 O O   . ASN E 5 164 ? 17.083  -40.049 -11.224 1.00 41.84  ? 158 ASN L O   1 
ATOM   7695 C CB  . ASN E 5 164 ? 15.073  -40.866 -12.971 1.00 30.74  ? 158 ASN L CB  1 
ATOM   7696 C CG  . ASN E 5 164 ? 15.899  -40.872 -14.243 1.00 45.21  ? 158 ASN L CG  1 
ATOM   7697 O OD1 . ASN E 5 164 ? 16.424  -39.838 -14.663 1.00 54.04  ? 158 ASN L OD1 1 
ATOM   7698 N ND2 . ASN E 5 164 ? 16.027  -42.041 -14.861 1.00 38.14  ? 158 ASN L ND2 1 
ATOM   7699 N N   . SER E 5 165 ? 16.780  -37.880 -11.728 1.00 35.50  ? 159 SER L N   1 
ATOM   7700 C CA  . SER E 5 165 ? 18.039  -37.455 -11.139 1.00 42.16  ? 159 SER L CA  1 
ATOM   7701 C C   . SER E 5 165 ? 17.803  -36.222 -10.281 1.00 46.10  ? 159 SER L C   1 
ATOM   7702 O O   . SER E 5 165 ? 16.950  -35.387 -10.599 1.00 47.54  ? 159 SER L O   1 
ATOM   7703 C CB  . SER E 5 165 ? 19.100  -37.162 -12.218 1.00 37.99  ? 159 SER L CB  1 
ATOM   7704 O OG  . SER E 5 165 ? 18.695  -36.118 -13.088 1.00 47.24  ? 159 SER L OG  1 
ATOM   7705 N N   . GLN E 5 166 ? 18.552  -36.125 -9.183  1.00 42.58  ? 160 GLN L N   1 
ATOM   7706 C CA  . GLN E 5 166 ? 18.524  -34.954 -8.320  1.00 58.49  ? 160 GLN L CA  1 
ATOM   7707 C C   . GLN E 5 166 ? 19.946  -34.607 -7.901  1.00 44.24  ? 160 GLN L C   1 
ATOM   7708 O O   . GLN E 5 166 ? 20.802  -35.485 -7.765  1.00 36.28  ? 160 GLN L O   1 
ATOM   7709 C CB  . GLN E 5 166 ? 17.620  -35.176 -7.097  1.00 54.97  ? 160 GLN L CB  1 
ATOM   7710 C CG  . GLN E 5 166 ? 16.132  -34.974 -7.404  1.00 76.13  ? 160 GLN L CG  1 
ATOM   7711 C CD  . GLN E 5 166 ? 15.217  -35.591 -6.362  1.00 81.85  ? 160 GLN L CD  1 
ATOM   7712 O OE1 . GLN E 5 166 ? 15.657  -35.965 -5.274  1.00 78.79  ? 160 GLN L OE1 1 
ATOM   7713 N NE2 . GLN E 5 166 ? 13.933  -35.704 -6.693  1.00 71.80  ? 160 GLN L NE2 1 
ATOM   7714 N N   . GLU E 5 167 ? 20.187  -33.311 -7.704  1.00 48.52  ? 161 GLU L N   1 
ATOM   7715 C CA  . GLU E 5 167 ? 21.523  -32.781 -7.478  1.00 38.64  ? 161 GLU L CA  1 
ATOM   7716 C C   . GLU E 5 167 ? 21.587  -32.016 -6.164  1.00 38.23  ? 161 GLU L C   1 
ATOM   7717 O O   . GLU E 5 167 ? 20.590  -31.461 -5.691  1.00 43.60  ? 161 GLU L O   1 
ATOM   7718 C CB  . GLU E 5 167 ? 21.956  -31.861 -8.627  1.00 35.20  ? 161 GLU L CB  1 
ATOM   7719 C CG  . GLU E 5 167 ? 21.806  -32.502 -9.995  1.00 60.83  ? 161 GLU L CG  1 
ATOM   7720 C CD  . GLU E 5 167 ? 22.651  -31.829 -11.056 1.00 66.83  ? 161 GLU L CD  1 
ATOM   7721 O OE1 . GLU E 5 167 ? 22.632  -32.297 -12.215 1.00 63.52  ? 161 GLU L OE1 1 
ATOM   7722 O OE2 . GLU E 5 167 ? 23.339  -30.838 -10.731 1.00 65.87  ? 161 GLU L OE2 1 
ATOM   7723 N N   . SER E 5 168 ? 22.780  -31.997 -5.581  1.00 34.98  ? 162 SER L N   1 
ATOM   7724 C CA  . SER E 5 168 ? 23.033  -31.294 -4.337  1.00 24.71  ? 162 SER L CA  1 
ATOM   7725 C C   . SER E 5 168 ? 24.411  -30.659 -4.421  1.00 30.11  ? 162 SER L C   1 
ATOM   7726 O O   . SER E 5 168 ? 25.356  -31.277 -4.917  1.00 36.95  ? 162 SER L O   1 
ATOM   7727 C CB  . SER E 5 168 ? 22.947  -32.240 -3.136  1.00 26.33  ? 162 SER L CB  1 
ATOM   7728 O OG  . SER E 5 168 ? 23.146  -31.535 -1.927  1.00 42.69  ? 162 SER L OG  1 
ATOM   7729 N N   . VAL E 5 169 ? 24.518  -29.420 -3.950  1.00 35.36  ? 163 VAL L N   1 
ATOM   7730 C CA  . VAL E 5 169 ? 25.751  -28.650 -4.037  1.00 34.88  ? 163 VAL L CA  1 
ATOM   7731 C C   . VAL E 5 169 ? 26.162  -28.232 -2.635  1.00 36.08  ? 163 VAL L C   1 
ATOM   7732 O O   . VAL E 5 169 ? 25.342  -27.705 -1.874  1.00 33.22  ? 163 VAL L O   1 
ATOM   7733 C CB  . VAL E 5 169 ? 25.589  -27.414 -4.941  1.00 28.32  ? 163 VAL L CB  1 
ATOM   7734 C CG1 . VAL E 5 169 ? 26.933  -26.753 -5.156  1.00 32.51  ? 163 VAL L CG1 1 
ATOM   7735 C CG2 . VAL E 5 169 ? 24.963  -27.800 -6.268  1.00 38.90  ? 163 VAL L CG2 1 
ATOM   7736 N N   . THR E 5 170 ? 27.426  -28.466 -2.296  1.00 35.69  ? 164 THR L N   1 
ATOM   7737 C CA  . THR E 5 170 ? 27.947  -27.987 -1.027  1.00 44.11  ? 164 THR L CA  1 
ATOM   7738 C C   . THR E 5 170 ? 28.190  -26.482 -1.085  1.00 46.87  ? 164 THR L C   1 
ATOM   7739 O O   . THR E 5 170 ? 28.197  -25.864 -2.154  1.00 43.68  ? 164 THR L O   1 
ATOM   7740 C CB  . THR E 5 170 ? 29.254  -28.695 -0.664  1.00 34.22  ? 164 THR L CB  1 
ATOM   7741 O OG1 . THR E 5 170 ? 30.214  -28.488 -1.706  1.00 34.16  ? 164 THR L OG1 1 
ATOM   7742 C CG2 . THR E 5 170 ? 29.030  -30.189 -0.466  1.00 31.67  ? 164 THR L CG2 1 
ATOM   7743 N N   . GLU E 5 171 ? 28.387  -25.892 0.091   1.00 51.51  ? 165 GLU L N   1 
ATOM   7744 C CA  . GLU E 5 171 ? 28.739  -24.483 0.156   1.00 54.54  ? 165 GLU L CA  1 
ATOM   7745 C C   . GLU E 5 171 ? 30.200  -24.292 -0.253  1.00 46.26  ? 165 GLU L C   1 
ATOM   7746 O O   . GLU E 5 171 ? 30.959  -25.251 -0.427  1.00 56.75  ? 165 GLU L O   1 
ATOM   7747 C CB  . GLU E 5 171 ? 28.486  -23.925 1.561   1.00 42.62  ? 165 GLU L CB  1 
ATOM   7748 C CG  . GLU E 5 171 ? 27.032  -24.023 2.058   1.00 56.63  ? 165 GLU L CG  1 
ATOM   7749 C CD  . GLU E 5 171 ? 26.087  -22.982 1.451   1.00 74.84  ? 165 GLU L CD  1 
ATOM   7750 O OE1 . GLU E 5 171 ? 26.341  -22.499 0.327   1.00 75.08  ? 165 GLU L OE1 1 
ATOM   7751 O OE2 . GLU E 5 171 ? 25.075  -22.648 2.107   1.00 64.80  ? 165 GLU L OE2 1 
ATOM   7752 N N   . GLN E 5 172 ? 30.593  -23.033 -0.423  1.00 41.04  ? 166 GLN L N   1 
ATOM   7753 C CA  . GLN E 5 172 ? 31.960  -22.737 -0.828  1.00 48.29  ? 166 GLN L CA  1 
ATOM   7754 C C   . GLN E 5 172 ? 32.927  -23.138 0.277   1.00 41.70  ? 166 GLN L C   1 
ATOM   7755 O O   . GLN E 5 172 ? 32.758  -22.745 1.436   1.00 55.29  ? 166 GLN L O   1 
ATOM   7756 C CB  . GLN E 5 172 ? 32.106  -21.252 -1.151  1.00 45.78  ? 166 GLN L CB  1 
ATOM   7757 C CG  . GLN E 5 172 ? 33.391  -20.904 -1.873  1.00 40.04  ? 166 GLN L CG  1 
ATOM   7758 C CD  . GLN E 5 172 ? 33.481  -19.431 -2.203  1.00 53.54  ? 166 GLN L CD  1 
ATOM   7759 O OE1 . GLN E 5 172 ? 32.949  -18.590 -1.478  1.00 56.30  ? 166 GLN L OE1 1 
ATOM   7760 N NE2 . GLN E 5 172 ? 34.148  -19.109 -3.306  1.00 45.00  ? 166 GLN L NE2 1 
ATOM   7761 N N   . ASP E 5 173 ? 33.940  -23.925 -0.082  1.00 44.51  ? 167 ASP L N   1 
ATOM   7762 C CA  . ASP E 5 173 ? 34.902  -24.401 0.904   1.00 57.26  ? 167 ASP L CA  1 
ATOM   7763 C C   . ASP E 5 173 ? 35.689  -23.232 1.482   1.00 64.58  ? 167 ASP L C   1 
ATOM   7764 O O   . ASP E 5 173 ? 36.035  -22.283 0.773   1.00 63.66  ? 167 ASP L O   1 
ATOM   7765 C CB  . ASP E 5 173 ? 35.846  -25.423 0.269   1.00 63.04  ? 167 ASP L CB  1 
ATOM   7766 C CG  . ASP E 5 173 ? 36.602  -26.242 1.302   1.00 76.34  ? 167 ASP L CG  1 
ATOM   7767 O OD1 . ASP E 5 173 ? 37.352  -25.651 2.107   1.00 81.53  ? 167 ASP L OD1 1 
ATOM   7768 O OD2 . ASP E 5 173 ? 36.436  -27.480 1.313   1.00 69.24  ? 167 ASP L OD2 1 
ATOM   7769 N N   . SER E 5 174 ? 35.972  -23.301 2.782   1.00 66.25  ? 168 SER L N   1 
ATOM   7770 C CA  . SER E 5 174 ? 36.554  -22.158 3.474   1.00 71.77  ? 168 SER L CA  1 
ATOM   7771 C C   . SER E 5 174 ? 38.063  -22.033 3.287   1.00 80.09  ? 168 SER L C   1 
ATOM   7772 O O   . SER E 5 174 ? 38.640  -21.040 3.743   1.00 76.36  ? 168 SER L O   1 
ATOM   7773 C CB  . SER E 5 174 ? 36.230  -22.228 4.968   1.00 64.03  ? 168 SER L CB  1 
ATOM   7774 O OG  . SER E 5 174 ? 36.518  -20.992 5.596   1.00 81.10  ? 168 SER L OG  1 
ATOM   7775 N N   . LYS E 5 175 ? 38.713  -22.994 2.630   1.00 78.03  ? 169 LYS L N   1 
ATOM   7776 C CA  . LYS E 5 175 ? 40.156  -22.959 2.417   1.00 69.22  ? 169 LYS L CA  1 
ATOM   7777 C C   . LYS E 5 175 ? 40.538  -22.651 0.978   1.00 65.45  ? 169 LYS L C   1 
ATOM   7778 O O   . LYS E 5 175 ? 41.325  -21.732 0.729   1.00 67.68  ? 169 LYS L O   1 
ATOM   7779 C CB  . LYS E 5 175 ? 40.789  -24.292 2.843   1.00 67.34  ? 169 LYS L CB  1 
ATOM   7780 C CG  . LYS E 5 175 ? 40.598  -24.625 4.312   1.00 83.50  ? 169 LYS L CG  1 
ATOM   7781 C CD  . LYS E 5 175 ? 41.494  -25.776 4.747   1.00 85.06  ? 169 LYS L CD  1 
ATOM   7782 C CE  . LYS E 5 175 ? 42.955  -25.348 4.872   1.00 80.62  ? 169 LYS L CE  1 
ATOM   7783 N NZ  . LYS E 5 175 ? 43.220  -24.527 6.091   1.00 78.15  ? 169 LYS L NZ  1 
ATOM   7784 N N   . ASP E 5 176 ? 40.004  -23.401 0.018   1.00 66.13  ? 170 ASP L N   1 
ATOM   7785 C CA  . ASP E 5 176 ? 40.320  -23.196 -1.388  1.00 62.99  ? 170 ASP L CA  1 
ATOM   7786 C C   . ASP E 5 176 ? 39.168  -22.593 -2.180  1.00 57.53  ? 170 ASP L C   1 
ATOM   7787 O O   . ASP E 5 176 ? 39.302  -22.413 -3.395  1.00 55.95  ? 170 ASP L O   1 
ATOM   7788 C CB  . ASP E 5 176 ? 40.765  -24.519 -2.022  1.00 59.71  ? 170 ASP L CB  1 
ATOM   7789 C CG  . ASP E 5 176 ? 39.831  -25.663 -1.694  1.00 74.78  ? 170 ASP L CG  1 
ATOM   7790 O OD1 . ASP E 5 176 ? 40.070  -26.786 -2.188  1.00 83.98  ? 170 ASP L OD1 1 
ATOM   7791 O OD2 . ASP E 5 176 ? 38.854  -25.439 -0.950  1.00 80.55  ? 170 ASP L OD2 1 
ATOM   7792 N N   . SER E 5 177 ? 38.048  -22.274 -1.524  1.00 54.31  ? 171 SER L N   1 
ATOM   7793 C CA  . SER E 5 177 ? 36.919  -21.565 -2.137  1.00 52.74  ? 171 SER L CA  1 
ATOM   7794 C C   . SER E 5 177 ? 36.386  -22.291 -3.373  1.00 52.04  ? 171 SER L C   1 
ATOM   7795 O O   . SER E 5 177 ? 35.949  -21.669 -4.343  1.00 52.18  ? 171 SER L O   1 
ATOM   7796 C CB  . SER E 5 177 ? 37.286  -20.112 -2.467  1.00 52.36  ? 171 SER L CB  1 
ATOM   7797 O OG  . SER E 5 177 ? 38.292  -20.022 -3.460  1.00 55.89  ? 171 SER L OG  1 
ATOM   7798 N N   . THR E 5 178 ? 36.399  -23.618 -3.330  1.00 49.84  ? 172 THR L N   1 
ATOM   7799 C CA  . THR E 5 178 ? 35.862  -24.440 -4.403  1.00 42.00  ? 172 THR L CA  1 
ATOM   7800 C C   . THR E 5 178 ? 34.495  -24.994 -4.014  1.00 44.38  ? 172 THR L C   1 
ATOM   7801 O O   . THR E 5 178 ? 34.058  -24.905 -2.864  1.00 38.52  ? 172 THR L O   1 
ATOM   7802 C CB  . THR E 5 178 ? 36.818  -25.588 -4.744  1.00 43.99  ? 172 THR L CB  1 
ATOM   7803 O OG1 . THR E 5 178 ? 37.178  -26.283 -3.544  1.00 58.05  ? 172 THR L OG1 1 
ATOM   7804 C CG2 . THR E 5 178 ? 38.072  -25.064 -5.424  1.00 38.16  ? 172 THR L CG2 1 
ATOM   7805 N N   . TYR E 5 179 ? 33.820  -25.577 -5.000  1.00 39.92  ? 173 TYR L N   1 
ATOM   7806 C CA  . TYR E 5 179 ? 32.505  -26.168 -4.811  1.00 44.32  ? 173 TYR L CA  1 
ATOM   7807 C C   . TYR E 5 179 ? 32.545  -27.645 -5.176  1.00 47.94  ? 173 TYR L C   1 
ATOM   7808 O O   . TYR E 5 179 ? 33.387  -28.085 -5.967  1.00 45.74  ? 173 TYR L O   1 
ATOM   7809 C CB  . TYR E 5 179 ? 31.435  -25.454 -5.655  1.00 39.17  ? 173 TYR L CB  1 
ATOM   7810 C CG  . TYR E 5 179 ? 31.146  -24.033 -5.221  1.00 38.11  ? 173 TYR L CG  1 
ATOM   7811 C CD1 . TYR E 5 179 ? 30.221  -23.766 -4.218  1.00 36.98  ? 173 TYR L CD1 1 
ATOM   7812 C CD2 . TYR E 5 179 ? 31.795  -22.958 -5.815  1.00 38.18  ? 173 TYR L CD2 1 
ATOM   7813 C CE1 . TYR E 5 179 ? 29.956  -22.467 -3.817  1.00 43.43  ? 173 TYR L CE1 1 
ATOM   7814 C CE2 . TYR E 5 179 ? 31.536  -21.659 -5.422  1.00 41.08  ? 173 TYR L CE2 1 
ATOM   7815 C CZ  . TYR E 5 179 ? 30.617  -21.419 -4.423  1.00 49.51  ? 173 TYR L CZ  1 
ATOM   7816 O OH  . TYR E 5 179 ? 30.360  -20.124 -4.033  1.00 50.55  ? 173 TYR L OH  1 
ATOM   7817 N N   . SER E 5 180 ? 31.633  -28.409 -4.579  1.00 39.65  ? 174 SER L N   1 
ATOM   7818 C CA  . SER E 5 180 ? 31.468  -29.822 -4.881  1.00 39.51  ? 174 SER L CA  1 
ATOM   7819 C C   . SER E 5 180 ? 30.002  -30.109 -5.167  1.00 46.76  ? 174 SER L C   1 
ATOM   7820 O O   . SER E 5 180 ? 29.112  -29.583 -4.492  1.00 48.49  ? 174 SER L O   1 
ATOM   7821 C CB  . SER E 5 180 ? 31.969  -30.706 -3.733  1.00 42.41  ? 174 SER L CB  1 
ATOM   7822 O OG  . SER E 5 180 ? 33.385  -30.676 -3.653  1.00 47.29  ? 174 SER L OG  1 
ATOM   7823 N N   . LEU E 5 181 ? 29.760  -30.943 -6.173  1.00 39.38  ? 175 LEU L N   1 
ATOM   7824 C CA  . LEU E 5 181 ? 28.414  -31.269 -6.615  1.00 38.52  ? 175 LEU L CA  1 
ATOM   7825 C C   . LEU E 5 181 ? 28.270  -32.779 -6.729  1.00 38.56  ? 175 LEU L C   1 
ATOM   7826 O O   . LEU E 5 181 ? 29.225  -33.478 -7.085  1.00 38.05  ? 175 LEU L O   1 
ATOM   7827 C CB  . LEU E 5 181 ? 28.100  -30.586 -7.960  1.00 36.75  ? 175 LEU L CB  1 
ATOM   7828 C CG  . LEU E 5 181 ? 26.726  -30.800 -8.596  1.00 40.92  ? 175 LEU L CG  1 
ATOM   7829 C CD1 . LEU E 5 181 ? 26.250  -29.531 -9.283  1.00 36.59  ? 175 LEU L CD1 1 
ATOM   7830 C CD2 . LEU E 5 181 ? 26.772  -31.949 -9.591  1.00 48.25  ? 175 LEU L CD2 1 
ATOM   7831 N N   . SER E 5 182 ? 27.077  -33.277 -6.408  1.00 31.76  ? 176 SER L N   1 
ATOM   7832 C CA  . SER E 5 182 ? 26.738  -34.687 -6.553  1.00 35.53  ? 176 SER L CA  1 
ATOM   7833 C C   . SER E 5 182 ? 25.401  -34.803 -7.264  1.00 42.21  ? 176 SER L C   1 
ATOM   7834 O O   . SER E 5 182 ? 24.411  -34.205 -6.831  1.00 43.02  ? 176 SER L O   1 
ATOM   7835 C CB  . SER E 5 182 ? 26.659  -35.392 -5.196  1.00 43.46  ? 176 SER L CB  1 
ATOM   7836 O OG  . SER E 5 182 ? 25.503  -34.985 -4.481  1.00 40.22  ? 176 SER L OG  1 
ATOM   7837 N N   . SER E 5 183 ? 25.371  -35.578 -8.342  1.00 38.20  ? 177 SER L N   1 
ATOM   7838 C CA  . SER E 5 183 ? 24.144  -35.877 -9.066  1.00 38.98  ? 177 SER L CA  1 
ATOM   7839 C C   . SER E 5 183 ? 23.863  -37.367 -8.928  1.00 40.79  ? 177 SER L C   1 
ATOM   7840 O O   . SER E 5 183 ? 24.710  -38.195 -9.279  1.00 44.04  ? 177 SER L O   1 
ATOM   7841 C CB  . SER E 5 183 ? 24.262  -35.479 -10.536 1.00 40.44  ? 177 SER L CB  1 
ATOM   7842 O OG  . SER E 5 183 ? 23.023  -35.638 -11.205 1.00 48.61  ? 177 SER L OG  1 
ATOM   7843 N N   . THR E 5 184 ? 22.681  -37.707 -8.423  1.00 37.46  ? 178 THR L N   1 
ATOM   7844 C CA  . THR E 5 184 ? 22.317  -39.092 -8.153  1.00 42.77  ? 178 THR L CA  1 
ATOM   7845 C C   . THR E 5 184 ? 21.202  -39.520 -9.099  1.00 45.15  ? 178 THR L C   1 
ATOM   7846 O O   . THR E 5 184 ? 20.139  -38.890 -9.141  1.00 38.15  ? 178 THR L O   1 
ATOM   7847 C CB  . THR E 5 184 ? 21.888  -39.269 -6.697  1.00 39.87  ? 178 THR L CB  1 
ATOM   7848 O OG1 . THR E 5 184 ? 22.972  -38.904 -5.834  1.00 55.23  ? 178 THR L OG1 1 
ATOM   7849 C CG2 . THR E 5 184 ? 21.504  -40.716 -6.428  1.00 31.84  ? 178 THR L CG2 1 
ATOM   7850 N N   . LEU E 5 185 ? 21.449  -40.591 -9.850  1.00 35.09  ? 179 LEU L N   1 
ATOM   7851 C CA  . LEU E 5 185 ? 20.465  -41.179 -10.750 1.00 38.39  ? 179 LEU L CA  1 
ATOM   7852 C C   . LEU E 5 185 ? 19.868  -42.408 -10.077 1.00 38.26  ? 179 LEU L C   1 
ATOM   7853 O O   . LEU E 5 185 ? 20.583  -43.377 -9.806  1.00 46.29  ? 179 LEU L O   1 
ATOM   7854 C CB  . LEU E 5 185 ? 21.105  -41.561 -12.084 1.00 43.74  ? 179 LEU L CB  1 
ATOM   7855 C CG  . LEU E 5 185 ? 20.167  -42.102 -13.164 1.00 48.15  ? 179 LEU L CG  1 
ATOM   7856 C CD1 . LEU E 5 185 ? 19.323  -40.979 -13.740 1.00 45.04  ? 179 LEU L CD1 1 
ATOM   7857 C CD2 . LEU E 5 185 ? 20.951  -42.807 -14.258 1.00 32.30  ? 179 LEU L CD2 1 
ATOM   7858 N N   . THR E 5 186 ? 18.566  -42.372 -9.816  1.00 40.69  ? 180 THR L N   1 
ATOM   7859 C CA  . THR E 5 186 ? 17.883  -43.446 -9.108  1.00 47.55  ? 180 THR L CA  1 
ATOM   7860 C C   . THR E 5 186 ? 16.993  -44.219 -10.072 1.00 50.87  ? 180 THR L C   1 
ATOM   7861 O O   . THR E 5 186 ? 16.187  -43.624 -10.796 1.00 39.07  ? 180 THR L O   1 
ATOM   7862 C CB  . THR E 5 186 ? 17.059  -42.897 -7.943  1.00 53.29  ? 180 THR L CB  1 
ATOM   7863 O OG1 . THR E 5 186 ? 17.907  -42.119 -7.089  1.00 57.35  ? 180 THR L OG1 1 
ATOM   7864 C CG2 . THR E 5 186 ? 16.458  -44.036 -7.138  1.00 39.11  ? 180 THR L CG2 1 
ATOM   7865 N N   . LEU E 5 187 ? 17.144  -45.541 -10.075 1.00 54.18  ? 181 LEU L N   1 
ATOM   7866 C CA  . LEU E 5 187 ? 16.385  -46.419 -10.950 1.00 49.51  ? 181 LEU L CA  1 
ATOM   7867 C C   . LEU E 5 187 ? 16.001  -47.678 -10.191 1.00 53.10  ? 181 LEU L C   1 
ATOM   7868 O O   . LEU E 5 187 ? 16.660  -48.064 -9.222  1.00 59.11  ? 181 LEU L O   1 
ATOM   7869 C CB  . LEU E 5 187 ? 17.184  -46.803 -12.201 1.00 45.88  ? 181 LEU L CB  1 
ATOM   7870 C CG  . LEU E 5 187 ? 17.175  -45.820 -13.367 1.00 52.26  ? 181 LEU L CG  1 
ATOM   7871 C CD1 . LEU E 5 187 ? 18.364  -46.083 -14.270 1.00 37.11  ? 181 LEU L CD1 1 
ATOM   7872 C CD2 . LEU E 5 187 ? 15.876  -45.949 -14.144 1.00 72.17  ? 181 LEU L CD2 1 
ATOM   7873 N N   . SER E 5 188 ? 14.925  -48.313 -10.640 1.00 50.43  ? 182 SER L N   1 
ATOM   7874 C CA  . SER E 5 188 ? 14.569  -49.616 -10.106 1.00 57.80  ? 182 SER L CA  1 
ATOM   7875 C C   . SER E 5 188 ? 15.506  -50.679 -10.669 1.00 58.35  ? 182 SER L C   1 
ATOM   7876 O O   . SER E 5 188 ? 16.174  -50.477 -11.687 1.00 57.40  ? 182 SER L O   1 
ATOM   7877 C CB  . SER E 5 188 ? 13.122  -49.961 -10.445 1.00 58.42  ? 182 SER L CB  1 
ATOM   7878 O OG  . SER E 5 188 ? 12.967  -50.136 -11.842 1.00 51.75  ? 182 SER L OG  1 
ATOM   7879 N N   . LYS E 5 189 ? 15.551  -51.827 -9.989  1.00 61.99  ? 183 LYS L N   1 
ATOM   7880 C CA  . LYS E 5 189 ? 16.398  -52.917 -10.459 1.00 60.26  ? 183 LYS L CA  1 
ATOM   7881 C C   . LYS E 5 189 ? 15.979  -53.383 -11.849 1.00 60.38  ? 183 LYS L C   1 
ATOM   7882 O O   . LYS E 5 189 ? 16.830  -53.614 -12.714 1.00 56.99  ? 183 LYS L O   1 
ATOM   7883 C CB  . LYS E 5 189 ? 16.375  -54.081 -9.466  1.00 56.70  ? 183 LYS L CB  1 
ATOM   7884 C CG  . LYS E 5 189 ? 16.763  -55.421 -10.086 1.00 75.50  ? 183 LYS L CG  1 
ATOM   7885 C CD  . LYS E 5 189 ? 17.153  -56.455 -9.041  1.00 69.44  ? 183 LYS L CD  1 
ATOM   7886 C CE  . LYS E 5 189 ? 18.582  -56.242 -8.571  1.00 63.52  ? 183 LYS L CE  1 
ATOM   7887 N NZ  . LYS E 5 189 ? 18.990  -57.245 -7.549  1.00 77.88  ? 183 LYS L NZ  1 
ATOM   7888 N N   . ALA E 5 190 ? 14.671  -53.506 -12.091 1.00 53.30  ? 184 ALA L N   1 
ATOM   7889 C CA  . ALA E 5 190 ? 14.208  -53.946 -13.404 1.00 52.86  ? 184 ALA L CA  1 
ATOM   7890 C C   . ALA E 5 190 ? 14.659  -52.988 -14.500 1.00 66.25  ? 184 ALA L C   1 
ATOM   7891 O O   . ALA E 5 190 ? 15.152  -53.421 -15.548 1.00 72.35  ? 184 ALA L O   1 
ATOM   7892 C CB  . ALA E 5 190 ? 12.686  -54.085 -13.406 1.00 52.25  ? 184 ALA L CB  1 
ATOM   7893 N N   . ASP E 5 191 ? 14.515  -51.681 -14.271 1.00 62.25  ? 185 ASP L N   1 
ATOM   7894 C CA  . ASP E 5 191 ? 14.974  -50.710 -15.257 1.00 62.62  ? 185 ASP L CA  1 
ATOM   7895 C C   . ASP E 5 191 ? 16.495  -50.662 -15.327 1.00 60.57  ? 185 ASP L C   1 
ATOM   7896 O O   . ASP E 5 191 ? 17.055  -50.431 -16.405 1.00 57.13  ? 185 ASP L O   1 
ATOM   7897 C CB  . ASP E 5 191 ? 14.404  -49.328 -14.931 1.00 68.25  ? 185 ASP L CB  1 
ATOM   7898 C CG  . ASP E 5 191 ? 12.998  -49.132 -15.472 1.00 75.44  ? 185 ASP L CG  1 
ATOM   7899 O OD1 . ASP E 5 191 ? 12.702  -48.027 -15.980 1.00 99.17  ? 185 ASP L OD1 1 
ATOM   7900 O OD2 . ASP E 5 191 ? 12.193  -50.085 -15.405 1.00 84.76  ? 185 ASP L OD2 1 
ATOM   7901 N N   . TYR E 5 192 ? 17.174  -50.880 -14.197 1.00 63.45  ? 186 TYR L N   1 
ATOM   7902 C CA  . TYR E 5 192 ? 18.631  -50.788 -14.169 1.00 60.60  ? 186 TYR L CA  1 
ATOM   7903 C C   . TYR E 5 192 ? 19.283  -51.924 -14.953 1.00 63.00  ? 186 TYR L C   1 
ATOM   7904 O O   . TYR E 5 192 ? 20.320  -51.723 -15.597 1.00 64.27  ? 186 TYR L O   1 
ATOM   7905 C CB  . TYR E 5 192 ? 19.129  -50.776 -12.721 1.00 49.95  ? 186 TYR L CB  1 
ATOM   7906 C CG  . TYR E 5 192 ? 20.639  -50.792 -12.585 1.00 59.16  ? 186 TYR L CG  1 
ATOM   7907 C CD1 . TYR E 5 192 ? 21.310  -51.955 -12.223 1.00 65.10  ? 186 TYR L CD1 1 
ATOM   7908 C CD2 . TYR E 5 192 ? 21.394  -49.648 -12.822 1.00 64.65  ? 186 TYR L CD2 1 
ATOM   7909 C CE1 . TYR E 5 192 ? 22.687  -51.980 -12.098 1.00 54.68  ? 186 TYR L CE1 1 
ATOM   7910 C CE2 . TYR E 5 192 ? 22.779  -49.664 -12.702 1.00 56.18  ? 186 TYR L CE2 1 
ATOM   7911 C CZ  . TYR E 5 192 ? 23.417  -50.836 -12.334 1.00 53.54  ? 186 TYR L CZ  1 
ATOM   7912 O OH  . TYR E 5 192 ? 24.788  -50.884 -12.206 1.00 51.41  ? 186 TYR L OH  1 
ATOM   7913 N N   . GLU E 5 193 ? 18.695  -53.117 -14.918 1.00 68.38  ? 187 GLU L N   1 
ATOM   7914 C CA  . GLU E 5 193 ? 19.300  -54.287 -15.543 1.00 72.47  ? 187 GLU L CA  1 
ATOM   7915 C C   . GLU E 5 193 ? 18.912  -54.452 -17.007 1.00 70.41  ? 187 GLU L C   1 
ATOM   7916 O O   . GLU E 5 193 ? 19.318  -55.438 -17.632 1.00 66.18  ? 187 GLU L O   1 
ATOM   7917 C CB  . GLU E 5 193 ? 18.931  -55.555 -14.765 1.00 55.73  ? 187 GLU L CB  1 
ATOM   7918 C CG  . GLU E 5 193 ? 19.245  -55.477 -13.280 1.00 62.95  ? 187 GLU L CG  1 
ATOM   7919 C CD  . GLU E 5 193 ? 20.153  -56.593 -12.809 1.00 82.87  ? 187 GLU L CD  1 
ATOM   7920 O OE1 . GLU E 5 193 ? 21.382  -56.377 -12.745 1.00 82.53  ? 187 GLU L OE1 1 
ATOM   7921 O OE2 . GLU E 5 193 ? 19.635  -57.689 -12.505 1.00 79.66  ? 187 GLU L OE2 1 
ATOM   7922 N N   . LYS E 5 194 ? 18.145  -53.521 -17.567 1.00 64.98  ? 188 LYS L N   1 
ATOM   7923 C CA  . LYS E 5 194 ? 17.792  -53.551 -18.979 1.00 63.75  ? 188 LYS L CA  1 
ATOM   7924 C C   . LYS E 5 194 ? 18.760  -52.756 -19.850 1.00 61.82  ? 188 LYS L C   1 
ATOM   7925 O O   . LYS E 5 194 ? 18.518  -52.622 -21.053 1.00 56.76  ? 188 LYS L O   1 
ATOM   7926 C CB  . LYS E 5 194 ? 16.364  -53.031 -19.181 1.00 59.35  ? 188 LYS L CB  1 
ATOM   7927 C CG  . LYS E 5 194 ? 15.287  -54.007 -18.741 1.00 59.95  ? 188 LYS L CG  1 
ATOM   7928 C CD  . LYS E 5 194 ? 13.892  -53.512 -19.098 1.00 64.32  ? 188 LYS L CD  1 
ATOM   7929 C CE  . LYS E 5 194 ? 13.515  -52.279 -18.298 1.00 64.84  ? 188 LYS L CE  1 
ATOM   7930 N NZ  . LYS E 5 194 ? 12.102  -51.878 -18.541 1.00 80.37  ? 188 LYS L NZ  1 
ATOM   7931 N N   . HIS E 5 195 ? 19.842  -52.229 -19.276 1.00 62.83  ? 189 HIS L N   1 
ATOM   7932 C CA  . HIS E 5 195 ? 20.800  -51.413 -20.010 1.00 57.65  ? 189 HIS L CA  1 
ATOM   7933 C C   . HIS E 5 195 ? 22.212  -51.735 -19.538 1.00 63.45  ? 189 HIS L C   1 
ATOM   7934 O O   . HIS E 5 195 ? 22.413  -52.291 -18.457 1.00 73.51  ? 189 HIS L O   1 
ATOM   7935 C CB  . HIS E 5 195 ? 20.519  -49.916 -19.832 1.00 55.65  ? 189 HIS L CB  1 
ATOM   7936 C CG  . HIS E 5 195 ? 19.146  -49.503 -20.262 1.00 58.09  ? 189 HIS L CG  1 
ATOM   7937 N ND1 . HIS E 5 195 ? 18.061  -49.526 -19.412 1.00 56.01  ? 189 HIS L ND1 1 
ATOM   7938 C CD2 . HIS E 5 195 ? 18.681  -49.056 -21.453 1.00 48.71  ? 189 HIS L CD2 1 
ATOM   7939 C CE1 . HIS E 5 195 ? 16.988  -49.110 -20.060 1.00 67.51  ? 189 HIS L CE1 1 
ATOM   7940 N NE2 . HIS E 5 195 ? 17.337  -48.820 -21.300 1.00 68.88  ? 189 HIS L NE2 1 
ATOM   7941 N N   . LYS E 5 196 ? 23.196  -51.369 -20.361 1.00 57.52  ? 190 LYS L N   1 
ATOM   7942 C CA  . LYS E 5 196 ? 24.598  -51.659 -20.077 1.00 58.41  ? 190 LYS L CA  1 
ATOM   7943 C C   . LYS E 5 196 ? 25.413  -50.421 -19.736 1.00 58.38  ? 190 LYS L C   1 
ATOM   7944 O O   . LYS E 5 196 ? 26.102  -50.399 -18.711 1.00 72.70  ? 190 LYS L O   1 
ATOM   7945 C CB  . LYS E 5 196 ? 25.250  -52.384 -21.267 1.00 53.32  ? 190 LYS L CB  1 
ATOM   7946 C CG  . LYS E 5 196 ? 25.069  -53.898 -21.272 1.00 70.51  ? 190 LYS L CG  1 
ATOM   7947 C CD  . LYS E 5 196 ? 23.665  -54.292 -21.708 1.00 78.05  ? 190 LYS L CD  1 
ATOM   7948 C CE  . LYS E 5 196 ? 23.357  -55.742 -21.361 1.00 68.70  ? 190 LYS L CE  1 
ATOM   7949 N NZ  . LYS E 5 196 ? 21.950  -56.100 -21.700 1.00 65.87  ? 190 LYS L NZ  1 
ATOM   7950 N N   . VAL E 5 197 ? 25.366  -49.389 -20.571 1.00 44.59  ? 191 VAL L N   1 
ATOM   7951 C CA  . VAL E 5 197 ? 26.250  -48.236 -20.444 1.00 51.87  ? 191 VAL L CA  1 
ATOM   7952 C C   . VAL E 5 197 ? 25.533  -47.143 -19.661 1.00 46.46  ? 191 VAL L C   1 
ATOM   7953 O O   . VAL E 5 197 ? 24.437  -46.711 -20.038 1.00 51.72  ? 191 VAL L O   1 
ATOM   7954 C CB  . VAL E 5 197 ? 26.702  -47.723 -21.820 1.00 48.93  ? 191 VAL L CB  1 
ATOM   7955 C CG1 . VAL E 5 197 ? 27.771  -46.655 -21.657 1.00 49.57  ? 191 VAL L CG1 1 
ATOM   7956 C CG2 . VAL E 5 197 ? 27.213  -48.875 -22.672 1.00 40.59  ? 191 VAL L CG2 1 
ATOM   7957 N N   . TYR E 5 198 ? 26.159  -46.692 -18.575 1.00 43.65  ? 192 TYR L N   1 
ATOM   7958 C CA  . TYR E 5 198 ? 25.653  -45.602 -17.746 1.00 46.27  ? 192 TYR L CA  1 
ATOM   7959 C C   . TYR E 5 198 ? 26.705  -44.504 -17.721 1.00 49.08  ? 192 TYR L C   1 
ATOM   7960 O O   . TYR E 5 198 ? 27.771  -44.674 -17.122 1.00 45.31  ? 192 TYR L O   1 
ATOM   7961 C CB  . TYR E 5 198 ? 25.331  -46.088 -16.335 1.00 40.61  ? 192 TYR L CB  1 
ATOM   7962 C CG  . TYR E 5 198 ? 24.140  -47.009 -16.282 1.00 43.36  ? 192 TYR L CG  1 
ATOM   7963 C CD1 . TYR E 5 198 ? 24.250  -48.340 -16.661 1.00 48.24  ? 192 TYR L CD1 1 
ATOM   7964 C CD2 . TYR E 5 198 ? 22.904  -46.547 -15.859 1.00 48.31  ? 192 TYR L CD2 1 
ATOM   7965 C CE1 . TYR E 5 198 ? 23.162  -49.184 -16.620 1.00 54.53  ? 192 TYR L CE1 1 
ATOM   7966 C CE2 . TYR E 5 198 ? 21.808  -47.384 -15.813 1.00 53.58  ? 192 TYR L CE2 1 
ATOM   7967 C CZ  . TYR E 5 198 ? 21.943  -48.701 -16.194 1.00 47.85  ? 192 TYR L CZ  1 
ATOM   7968 O OH  . TYR E 5 198 ? 20.854  -49.536 -16.149 1.00 56.84  ? 192 TYR L OH  1 
ATOM   7969 N N   . ALA E 5 199 ? 26.402  -43.379 -18.363 1.00 47.17  ? 193 ALA L N   1 
ATOM   7970 C CA  . ALA E 5 199 ? 27.361  -42.304 -18.553 1.00 35.30  ? 193 ALA L CA  1 
ATOM   7971 C C   . ALA E 5 199 ? 26.888  -41.037 -17.859 1.00 43.77  ? 193 ALA L C   1 
ATOM   7972 O O   . ALA E 5 199 ? 25.707  -40.679 -17.919 1.00 39.95  ? 193 ALA L O   1 
ATOM   7973 C CB  . ALA E 5 199 ? 27.587  -42.022 -20.040 1.00 40.74  ? 193 ALA L CB  1 
ATOM   7974 N N   . CYS E 5 200 ? 27.825  -40.366 -17.203 1.00 56.14  ? 194 CYS L N   1 
ATOM   7975 C CA  . CYS E 5 200 ? 27.606  -39.061 -16.599 1.00 49.00  ? 194 CYS L CA  1 
ATOM   7976 C C   . CYS E 5 200 ? 28.420  -38.040 -17.382 1.00 50.48  ? 194 CYS L C   1 
ATOM   7977 O O   . CYS E 5 200 ? 29.644  -38.171 -17.484 1.00 54.15  ? 194 CYS L O   1 
ATOM   7978 C CB  . CYS E 5 200 ? 28.017  -39.078 -15.128 1.00 43.65  ? 194 CYS L CB  1 
ATOM   7979 S SG  . CYS E 5 200 ? 28.096  -37.455 -14.370 1.00 69.80  ? 194 CYS L SG  1 
ATOM   7980 N N   . GLU E 5 201 ? 27.752  -37.034 -17.939 1.00 47.47  ? 195 GLU L N   1 
ATOM   7981 C CA  . GLU E 5 201 ? 28.410  -36.019 -18.753 1.00 51.27  ? 195 GLU L CA  1 
ATOM   7982 C C   . GLU E 5 201 ? 28.430  -34.691 -18.007 1.00 50.41  ? 195 GLU L C   1 
ATOM   7983 O O   . GLU E 5 201 ? 27.402  -34.257 -17.477 1.00 54.85  ? 195 GLU L O   1 
ATOM   7984 C CB  . GLU E 5 201 ? 27.708  -35.866 -20.102 1.00 55.01  ? 195 GLU L CB  1 
ATOM   7985 C CG  . GLU E 5 201 ? 28.468  -35.012 -21.097 1.00 68.87  ? 195 GLU L CG  1 
ATOM   7986 C CD  . GLU E 5 201 ? 27.765  -34.926 -22.432 1.00 77.99  ? 195 GLU L CD  1 
ATOM   7987 O OE1 . GLU E 5 201 ? 26.621  -35.418 -22.531 1.00 57.78  ? 195 GLU L OE1 1 
ATOM   7988 O OE2 . GLU E 5 201 ? 28.355  -34.369 -23.381 1.00 84.10  ? 195 GLU L OE2 1 
ATOM   7989 N N   . VAL E 5 202 ? 29.597  -34.046 -17.972 1.00 42.21  ? 196 VAL L N   1 
ATOM   7990 C CA  . VAL E 5 202 ? 29.810  -32.823 -17.205 1.00 43.48  ? 196 VAL L CA  1 
ATOM   7991 C C   . VAL E 5 202 ? 30.270  -31.717 -18.147 1.00 50.68  ? 196 VAL L C   1 
ATOM   7992 O O   . VAL E 5 202 ? 31.199  -31.911 -18.940 1.00 44.09  ? 196 VAL L O   1 
ATOM   7993 C CB  . VAL E 5 202 ? 30.834  -33.032 -16.073 1.00 38.06  ? 196 VAL L CB  1 
ATOM   7994 C CG1 . VAL E 5 202 ? 31.146  -31.709 -15.375 1.00 35.24  ? 196 VAL L CG1 1 
ATOM   7995 C CG2 . VAL E 5 202 ? 30.317  -34.053 -15.076 1.00 42.29  ? 196 VAL L CG2 1 
ATOM   7996 N N   . THR E 5 203 ? 29.621  -30.559 -18.052 1.00 48.87  ? 197 THR L N   1 
ATOM   7997 C CA  . THR E 5 203 ? 29.990  -29.368 -18.802 1.00 42.98  ? 197 THR L CA  1 
ATOM   7998 C C   . THR E 5 203 ? 30.355  -28.274 -17.809 1.00 40.57  ? 197 THR L C   1 
ATOM   7999 O O   . THR E 5 203 ? 29.576  -27.974 -16.899 1.00 47.13  ? 197 THR L O   1 
ATOM   8000 C CB  . THR E 5 203 ? 28.841  -28.911 -19.709 1.00 39.70  ? 197 THR L CB  1 
ATOM   8001 O OG1 . THR E 5 203 ? 28.340  -30.031 -20.450 1.00 51.45  ? 197 THR L OG1 1 
ATOM   8002 C CG2 . THR E 5 203 ? 29.321  -27.850 -20.680 1.00 38.28  ? 197 THR L CG2 1 
ATOM   8003 N N   . HIS E 5 204 ? 31.540  -27.689 -17.973 1.00 35.68  ? 198 HIS L N   1 
ATOM   8004 C CA  . HIS E 5 204 ? 32.008  -26.678 -17.035 1.00 41.68  ? 198 HIS L CA  1 
ATOM   8005 C C   . HIS E 5 204 ? 32.918  -25.698 -17.762 1.00 50.16  ? 198 HIS L C   1 
ATOM   8006 O O   . HIS E 5 204 ? 33.483  -26.006 -18.815 1.00 44.67  ? 198 HIS L O   1 
ATOM   8007 C CB  . HIS E 5 204 ? 32.734  -27.316 -15.843 1.00 36.28  ? 198 HIS L CB  1 
ATOM   8008 C CG  . HIS E 5 204 ? 33.032  -26.359 -14.731 1.00 29.82  ? 198 HIS L CG  1 
ATOM   8009 N ND1 . HIS E 5 204 ? 34.241  -25.708 -14.612 1.00 38.40  ? 198 HIS L ND1 1 
ATOM   8010 C CD2 . HIS E 5 204 ? 32.277  -25.942 -13.687 1.00 43.09  ? 198 HIS L CD2 1 
ATOM   8011 C CE1 . HIS E 5 204 ? 34.218  -24.931 -13.544 1.00 40.42  ? 198 HIS L CE1 1 
ATOM   8012 N NE2 . HIS E 5 204 ? 33.038  -25.055 -12.964 1.00 39.82  ? 198 HIS L NE2 1 
ATOM   8013 N N   . GLN E 5 205 ? 33.051  -24.504 -17.176 1.00 41.66  ? 199 GLN L N   1 
ATOM   8014 C CA  . GLN E 5 205 ? 33.863  -23.456 -17.788 1.00 48.07  ? 199 GLN L CA  1 
ATOM   8015 C C   . GLN E 5 205 ? 35.329  -23.865 -17.872 1.00 60.52  ? 199 GLN L C   1 
ATOM   8016 O O   . GLN E 5 205 ? 36.018  -23.542 -18.848 1.00 55.79  ? 199 GLN L O   1 
ATOM   8017 C CB  . GLN E 5 205 ? 33.710  -22.153 -17.002 1.00 41.33  ? 199 GLN L CB  1 
ATOM   8018 C CG  . GLN E 5 205 ? 34.558  -21.004 -17.522 1.00 45.09  ? 199 GLN L CG  1 
ATOM   8019 C CD  . GLN E 5 205 ? 34.398  -19.741 -16.697 1.00 59.35  ? 199 GLN L CD  1 
ATOM   8020 O OE1 . GLN E 5 205 ? 33.466  -19.619 -15.902 1.00 60.86  ? 199 GLN L OE1 1 
ATOM   8021 N NE2 . GLN E 5 205 ? 35.311  -18.795 -16.881 1.00 49.26  ? 199 GLN L NE2 1 
ATOM   8022 N N   . GLY E 5 206 ? 35.824  -24.576 -16.861 1.00 56.11  ? 200 GLY L N   1 
ATOM   8023 C CA  . GLY E 5 206 ? 37.199  -25.029 -16.818 1.00 49.90  ? 200 GLY L CA  1 
ATOM   8024 C C   . GLY E 5 206 ? 37.521  -26.235 -17.669 1.00 51.05  ? 200 GLY L C   1 
ATOM   8025 O O   . GLY E 5 206 ? 38.658  -26.715 -17.640 1.00 50.05  ? 200 GLY L O   1 
ATOM   8026 N N   . LEU E 5 207 ? 36.553  -26.749 -18.422 1.00 40.86  ? 201 LEU L N   1 
ATOM   8027 C CA  . LEU E 5 207 ? 36.760  -27.871 -19.327 1.00 47.92  ? 201 LEU L CA  1 
ATOM   8028 C C   . LEU E 5 207 ? 36.654  -27.378 -20.762 1.00 51.96  ? 201 LEU L C   1 
ATOM   8029 O O   . LEU E 5 207 ? 35.668  -26.729 -21.127 1.00 57.08  ? 201 LEU L O   1 
ATOM   8030 C CB  . LEU E 5 207 ? 35.736  -28.977 -19.071 1.00 50.58  ? 201 LEU L CB  1 
ATOM   8031 C CG  . LEU E 5 207 ? 35.688  -29.530 -17.647 1.00 41.88  ? 201 LEU L CG  1 
ATOM   8032 C CD1 . LEU E 5 207 ? 34.506  -30.465 -17.477 1.00 36.26  ? 201 LEU L CD1 1 
ATOM   8033 C CD2 . LEU E 5 207 ? 36.981  -30.249 -17.327 1.00 38.31  ? 201 LEU L CD2 1 
ATOM   8034 N N   . SER E 5 208 ? 37.675  -27.679 -21.570 1.00 62.40  ? 202 SER L N   1 
ATOM   8035 C CA  . SER E 5 208 ? 37.646  -27.282 -22.975 1.00 67.51  ? 202 SER L CA  1 
ATOM   8036 C C   . SER E 5 208 ? 36.507  -27.969 -23.716 1.00 68.24  ? 202 SER L C   1 
ATOM   8037 O O   . SER E 5 208 ? 35.819  -27.345 -24.533 1.00 67.90  ? 202 SER L O   1 
ATOM   8038 C CB  . SER E 5 208 ? 38.987  -27.596 -23.637 1.00 54.09  ? 202 SER L CB  1 
ATOM   8039 O OG  . SER E 5 208 ? 39.261  -28.985 -23.595 1.00 61.21  ? 202 SER L OG  1 
ATOM   8040 N N   . SER E 5 209 ? 36.296  -29.252 -23.446 1.00 73.04  ? 203 SER L N   1 
ATOM   8041 C CA  . SER E 5 209 ? 35.191  -30.025 -23.984 1.00 64.00  ? 203 SER L CA  1 
ATOM   8042 C C   . SER E 5 209 ? 34.507  -30.772 -22.849 1.00 63.04  ? 203 SER L C   1 
ATOM   8043 O O   . SER E 5 209 ? 35.125  -31.028 -21.810 1.00 60.14  ? 203 SER L O   1 
ATOM   8044 C CB  . SER E 5 209 ? 35.672  -31.021 -25.052 1.00 63.31  ? 203 SER L CB  1 
ATOM   8045 O OG  . SER E 5 209 ? 36.680  -31.878 -24.543 1.00 63.17  ? 203 SER L OG  1 
ATOM   8046 N N   . PRO E 5 210 ? 33.225  -31.108 -23.006 1.00 59.35  ? 204 PRO L N   1 
ATOM   8047 C CA  . PRO E 5 210 ? 32.533  -31.865 -21.956 1.00 59.91  ? 204 PRO L CA  1 
ATOM   8048 C C   . PRO E 5 210 ? 33.216  -33.199 -21.689 1.00 52.34  ? 204 PRO L C   1 
ATOM   8049 O O   . PRO E 5 210 ? 33.669  -33.883 -22.610 1.00 52.38  ? 204 PRO L O   1 
ATOM   8050 C CB  . PRO E 5 210 ? 31.124  -32.058 -22.529 1.00 43.61  ? 204 PRO L CB  1 
ATOM   8051 C CG  . PRO E 5 210 ? 30.951  -30.922 -23.479 1.00 45.90  ? 204 PRO L CG  1 
ATOM   8052 C CD  . PRO E 5 210 ? 32.307  -30.682 -24.077 1.00 55.23  ? 204 PRO L CD  1 
ATOM   8053 N N   . VAL E 5 211 ? 33.284  -33.567 -20.412 1.00 47.97  ? 205 VAL L N   1 
ATOM   8054 C CA  . VAL E 5 211 ? 33.889  -34.826 -19.994 1.00 47.52  ? 205 VAL L CA  1 
ATOM   8055 C C   . VAL E 5 211 ? 32.779  -35.823 -19.700 1.00 43.94  ? 205 VAL L C   1 
ATOM   8056 O O   . VAL E 5 211 ? 31.655  -35.449 -19.347 1.00 56.23  ? 205 VAL L O   1 
ATOM   8057 C CB  . VAL E 5 211 ? 34.807  -34.637 -18.768 1.00 43.71  ? 205 VAL L CB  1 
ATOM   8058 C CG1 . VAL E 5 211 ? 35.822  -33.531 -19.028 1.00 50.33  ? 205 VAL L CG1 1 
ATOM   8059 C CG2 . VAL E 5 211 ? 33.985  -34.332 -17.530 1.00 41.09  ? 205 VAL L CG2 1 
ATOM   8060 N N   . THR E 5 212 ? 33.092  -37.109 -19.858 1.00 49.28  ? 206 THR L N   1 
ATOM   8061 C CA  . THR E 5 212 ? 32.117  -38.173 -19.646 1.00 50.68  ? 206 THR L CA  1 
ATOM   8062 C C   . THR E 5 212 ? 32.774  -39.312 -18.884 1.00 44.59  ? 206 THR L C   1 
ATOM   8063 O O   . THR E 5 212 ? 33.738  -39.912 -19.368 1.00 52.89  ? 206 THR L O   1 
ATOM   8064 C CB  . THR E 5 212 ? 31.543  -38.679 -20.975 1.00 40.39  ? 206 THR L CB  1 
ATOM   8065 O OG1 . THR E 5 212 ? 30.847  -37.615 -21.634 1.00 50.75  ? 206 THR L OG1 1 
ATOM   8066 C CG2 . THR E 5 212 ? 30.576  -39.829 -20.735 1.00 43.97  ? 206 THR L CG2 1 
ATOM   8067 N N   . LYS E 5 213 ? 32.251  -39.603 -17.697 1.00 49.61  ? 207 LYS L N   1 
ATOM   8068 C CA  . LYS E 5 213 ? 32.634  -40.774 -16.923 1.00 49.91  ? 207 LYS L CA  1 
ATOM   8069 C C   . LYS E 5 213 ? 31.515  -41.802 -17.029 1.00 53.72  ? 207 LYS L C   1 
ATOM   8070 O O   . LYS E 5 213 ? 30.349  -41.485 -16.772 1.00 44.89  ? 207 LYS L O   1 
ATOM   8071 C CB  . LYS E 5 213 ? 32.897  -40.406 -15.460 1.00 37.30  ? 207 LYS L CB  1 
ATOM   8072 C CG  . LYS E 5 213 ? 34.271  -39.791 -15.193 1.00 47.89  ? 207 LYS L CG  1 
ATOM   8073 C CD  . LYS E 5 213 ? 35.384  -40.830 -15.316 1.00 71.35  ? 207 LYS L CD  1 
ATOM   8074 C CE  . LYS E 5 213 ? 36.750  -40.255 -14.951 1.00 64.34  ? 207 LYS L CE  1 
ATOM   8075 N NZ  . LYS E 5 213 ? 37.809  -41.307 -14.922 1.00 56.96  ? 207 LYS L NZ  1 
ATOM   8076 N N   . SER E 5 214 ? 31.865  -43.024 -17.423 1.00 49.12  ? 208 SER L N   1 
ATOM   8077 C CA  . SER E 5 214 ? 30.872  -44.059 -17.664 1.00 42.95  ? 208 SER L CA  1 
ATOM   8078 C C   . SER E 5 214 ? 31.400  -45.401 -17.182 1.00 48.48  ? 208 SER L C   1 
ATOM   8079 O O   . SER E 5 214 ? 32.598  -45.573 -16.944 1.00 60.06  ? 208 SER L O   1 
ATOM   8080 C CB  . SER E 5 214 ? 30.496  -44.143 -19.148 1.00 34.90  ? 208 SER L CB  1 
ATOM   8081 O OG  . SER E 5 214 ? 31.647  -44.349 -19.949 1.00 42.79  ? 208 SER L OG  1 
ATOM   8082 N N   . PHE E 5 215 ? 30.480  -46.352 -17.031 1.00 48.21  ? 209 PHE L N   1 
ATOM   8083 C CA  . PHE E 5 215 ? 30.827  -47.721 -16.683 1.00 46.85  ? 209 PHE L CA  1 
ATOM   8084 C C   . PHE E 5 215 ? 29.831  -48.658 -17.349 1.00 55.00  ? 209 PHE L C   1 
ATOM   8085 O O   . PHE E 5 215 ? 28.728  -48.254 -17.728 1.00 52.03  ? 209 PHE L O   1 
ATOM   8086 C CB  . PHE E 5 215 ? 30.842  -47.938 -15.162 1.00 47.51  ? 209 PHE L CB  1 
ATOM   8087 C CG  . PHE E 5 215 ? 29.474  -48.084 -14.552 1.00 53.82  ? 209 PHE L CG  1 
ATOM   8088 C CD1 . PHE E 5 215 ? 28.713  -46.968 -14.248 1.00 45.64  ? 209 PHE L CD1 1 
ATOM   8089 C CD2 . PHE E 5 215 ? 28.954  -49.339 -14.274 1.00 52.30  ? 209 PHE L CD2 1 
ATOM   8090 C CE1 . PHE E 5 215 ? 27.456  -47.100 -13.686 1.00 43.84  ? 209 PHE L CE1 1 
ATOM   8091 C CE2 . PHE E 5 215 ? 27.699  -49.479 -13.715 1.00 55.26  ? 209 PHE L CE2 1 
ATOM   8092 C CZ  . PHE E 5 215 ? 26.948  -48.358 -13.420 1.00 48.94  ? 209 PHE L CZ  1 
ATOM   8093 N N   . ASN E 5 216 ? 30.231  -49.919 -17.492 1.00 59.46  ? 210 ASN L N   1 
ATOM   8094 C CA  . ASN E 5 216 ? 29.372  -50.956 -18.047 1.00 55.92  ? 210 ASN L CA  1 
ATOM   8095 C C   . ASN E 5 216 ? 28.918  -51.889 -16.935 1.00 57.83  ? 210 ASN L C   1 
ATOM   8096 O O   . ASN E 5 216 ? 29.745  -52.422 -16.187 1.00 74.05  ? 210 ASN L O   1 
ATOM   8097 C CB  . ASN E 5 216 ? 30.093  -51.748 -19.139 1.00 67.37  ? 210 ASN L CB  1 
ATOM   8098 C CG  . ASN E 5 216 ? 30.432  -50.896 -20.343 1.00 61.41  ? 210 ASN L CG  1 
ATOM   8099 O OD1 . ASN E 5 216 ? 30.596  -49.682 -20.230 1.00 62.54  ? 210 ASN L OD1 1 
ATOM   8100 N ND2 . ASN E 5 216 ? 30.532  -51.528 -21.507 1.00 62.22  ? 210 ASN L ND2 1 
ATOM   8101 N N   . ARG E 5 217 ? 27.609  -52.087 -16.834 1.00 52.05  ? 211 ARG L N   1 
ATOM   8102 C CA  . ARG E 5 217 ? 27.037  -52.927 -15.791 1.00 69.10  ? 211 ARG L CA  1 
ATOM   8103 C C   . ARG E 5 217 ? 27.456  -54.388 -15.934 1.00 65.90  ? 211 ARG L C   1 
ATOM   8104 O O   . ARG E 5 217 ? 27.192  -55.023 -16.955 1.00 66.60  ? 211 ARG L O   1 
ATOM   8105 C CB  . ARG E 5 217 ? 25.515  -52.820 -15.806 1.00 53.86  ? 211 ARG L CB  1 
ATOM   8106 C CG  . ARG E 5 217 ? 24.832  -53.707 -14.789 1.00 62.37  ? 211 ARG L CG  1 
ATOM   8107 C CD  . ARG E 5 217 ? 23.333  -53.617 -14.941 1.00 64.30  ? 211 ARG L CD  1 
ATOM   8108 N NE  . ARG E 5 217 ? 22.929  -53.785 -16.328 1.00 69.88  ? 211 ARG L NE  1 
ATOM   8109 C CZ  . ARG E 5 217 ? 22.795  -54.958 -16.931 1.00 75.84  ? 211 ARG L CZ  1 
ATOM   8110 N NH1 . ARG E 5 217 ? 23.037  -56.094 -16.297 1.00 72.50  ? 211 ARG L NH1 1 
ATOM   8111 N NH2 . ARG E 5 217 ? 22.404  -54.992 -18.202 1.00 76.15  ? 211 ARG L NH2 1 
HETATM 8112 C C1  . NAG F 6 .   ? 17.858  7.527   40.785  1.00 53.64  ? 1   NAG B C1  1 
HETATM 8113 C C2  . NAG F 6 .   ? 19.250  7.526   40.123  1.00 54.55  ? 1   NAG B C2  1 
HETATM 8114 C C3  . NAG F 6 .   ? 19.786  6.099   40.004  1.00 61.96  ? 1   NAG B C3  1 
HETATM 8115 C C4  . NAG F 6 .   ? 19.607  5.256   41.274  1.00 62.76  ? 1   NAG B C4  1 
HETATM 8116 C C5  . NAG F 6 .   ? 18.178  5.423   41.822  1.00 57.56  ? 1   NAG B C5  1 
HETATM 8117 C C6  . NAG F 6 .   ? 17.888  4.704   43.131  1.00 69.71  ? 1   NAG B C6  1 
HETATM 8118 C C7  . NAG F 6 .   ? 18.484  8.702   37.967  1.00 61.40  ? 1   NAG B C7  1 
HETATM 8119 C C8  . NAG F 6 .   ? 19.088  9.115   36.646  1.00 52.19  ? 1   NAG B C8  1 
HETATM 8120 N N2  . NAG F 6 .   ? 19.364  8.094   38.793  1.00 64.54  ? 1   NAG B N2  1 
HETATM 8121 O O3  . NAG F 6 .   ? 21.125  6.245   39.593  1.00 80.17  ? 1   NAG B O3  1 
HETATM 8122 O O4  . NAG F 6 .   ? 19.845  3.906   40.931  1.00 69.04  ? 1   NAG B O4  1 
HETATM 8123 O O5  . NAG F 6 .   ? 17.917  6.801   41.991  1.00 64.25  ? 1   NAG B O5  1 
HETATM 8124 O O6  . NAG F 6 .   ? 16.521  4.767   43.489  1.00 53.31  ? 1   NAG B O6  1 
HETATM 8125 O O7  . NAG F 6 .   ? 17.308  8.930   38.204  1.00 73.25  ? 1   NAG B O7  1 
HETATM 8126 C C1  . NAG F 6 .   ? 21.237  3.557   41.098  1.00 84.55  ? 2   NAG B C1  1 
HETATM 8127 C C2  . NAG F 6 .   ? 21.330  2.089   41.551  1.00 88.34  ? 2   NAG B C2  1 
HETATM 8128 C C3  . NAG F 6 .   ? 22.782  1.608   41.541  1.00 92.52  ? 2   NAG B C3  1 
HETATM 8129 C C4  . NAG F 6 .   ? 23.446  1.924   40.204  1.00 95.44  ? 2   NAG B C4  1 
HETATM 8130 C C5  . NAG F 6 .   ? 23.303  3.427   39.935  1.00 77.88  ? 2   NAG B C5  1 
HETATM 8131 C C6  . NAG F 6 .   ? 23.940  3.908   38.649  1.00 73.88  ? 2   NAG B C6  1 
HETATM 8132 C C7  . NAG F 6 .   ? 19.462  1.614   43.092  1.00 91.25  ? 2   NAG B C7  1 
HETATM 8133 C C8  . NAG F 6 .   ? 19.085  1.504   44.550  1.00 83.37  ? 2   NAG B C8  1 
HETATM 8134 N N2  . NAG F 6 .   ? 20.750  1.929   42.860  1.00 86.90  ? 2   NAG B N2  1 
HETATM 8135 O O3  . NAG F 6 .   ? 22.794  0.233   41.821  1.00 100.29 ? 2   NAG B O3  1 
HETATM 8136 O O4  . NAG F 6 .   ? 24.792  1.512   40.289  1.00 97.96  ? 2   NAG B O4  1 
HETATM 8137 O O5  . NAG F 6 .   ? 21.927  3.730   39.880  1.00 71.96  ? 2   NAG B O5  1 
HETATM 8138 O O6  . NAG F 6 .   ? 25.331  3.703   38.707  1.00 87.18  ? 2   NAG B O6  1 
HETATM 8139 O O7  . NAG F 6 .   ? 18.643  1.429   42.204  1.00 85.46  ? 2   NAG B O7  1 
HETATM 8140 C C1  . BMA F 6 .   ? 25.006  0.460   39.320  1.00 97.39  ? 3   BMA B C1  1 
HETATM 8141 C C2  . BMA F 6 .   ? 26.500  0.405   39.004  1.00 104.38 ? 3   BMA B C2  1 
HETATM 8142 C C3  . BMA F 6 .   ? 26.746  -0.750  38.007  1.00 106.93 ? 3   BMA B C3  1 
HETATM 8143 C C4  . BMA F 6 .   ? 26.120  -2.089  38.459  1.00 115.99 ? 3   BMA B C4  1 
HETATM 8144 C C5  . BMA F 6 .   ? 24.710  -1.944  39.041  1.00 109.64 ? 3   BMA B C5  1 
HETATM 8145 C C6  . BMA F 6 .   ? 24.223  -3.165  39.825  1.00 102.88 ? 3   BMA B C6  1 
HETATM 8146 O O2  . BMA F 6 .   ? 27.218  0.271   40.201  1.00 91.24  ? 3   BMA B O2  1 
HETATM 8147 O O3  . BMA F 6 .   ? 28.136  -0.808  37.784  1.00 110.06 ? 3   BMA B O3  1 
HETATM 8148 O O4  . BMA F 6 .   ? 26.107  -2.914  37.310  1.00 130.26 ? 3   BMA B O4  1 
HETATM 8149 O O5  . BMA F 6 .   ? 24.571  -0.785  39.844  1.00 105.10 ? 3   BMA B O5  1 
HETATM 8150 O O6  . BMA F 6 .   ? 22.810  -3.183  39.814  1.00 72.16  ? 3   BMA B O6  1 
HETATM 8151 C C1  . CIT G 7 .   ? -1.995  -1.639  33.968  1.00 79.55  ? 601 CIT A C1  1 
HETATM 8152 O O1  . CIT G 7 .   ? -3.079  -1.928  33.409  1.00 66.76  ? 601 CIT A O1  1 
HETATM 8153 O O2  . CIT G 7 .   ? -1.882  -1.157  35.115  1.00 56.98  ? 601 CIT A O2  1 
HETATM 8154 C C2  . CIT G 7 .   ? -0.690  -1.897  33.181  1.00 98.39  ? 601 CIT A C2  1 
HETATM 8155 C C3  . CIT G 7 .   ? 0.607   -1.425  33.870  1.00 99.98  ? 601 CIT A C3  1 
HETATM 8156 O O7  . CIT G 7 .   ? 0.405   -1.625  35.253  1.00 100.09 ? 601 CIT A O7  1 
HETATM 8157 C C4  . CIT G 7 .   ? 1.846   -2.225  33.417  1.00 97.83  ? 601 CIT A C4  1 
HETATM 8158 C C5  . CIT G 7 .   ? 1.917   -2.530  31.912  1.00 92.61  ? 601 CIT A C5  1 
HETATM 8159 O O3  . CIT G 7 .   ? 2.390   -1.671  31.148  1.00 77.56  ? 601 CIT A O3  1 
HETATM 8160 O O4  . CIT G 7 .   ? 1.487   -3.662  31.549  1.00 88.55  ? 601 CIT A O4  1 
HETATM 8161 C C6  . CIT G 7 .   ? 0.830   0.085   33.521  1.00 80.97  ? 601 CIT A C6  1 
HETATM 8162 O O5  . CIT G 7 .   ? -0.123  0.847   33.799  1.00 71.82  ? 601 CIT A O5  1 
HETATM 8163 O O6  . CIT G 7 .   ? 1.911   0.435   33.006  1.00 75.58  ? 601 CIT A O6  1 
HETATM 8164 C C1  . CIT H 7 .   ? 12.921  5.057   39.857  1.00 65.40  ? 602 CIT A C1  1 
HETATM 8165 O O1  . CIT H 7 .   ? 13.139  5.902   40.756  1.00 69.87  ? 602 CIT A O1  1 
HETATM 8166 O O2  . CIT H 7 .   ? 12.093  4.124   39.934  1.00 65.14  ? 602 CIT A O2  1 
HETATM 8167 C C2  . CIT H 7 .   ? 13.733  5.168   38.547  1.00 70.78  ? 602 CIT A C2  1 
HETATM 8168 C C3  . CIT H 7 .   ? 15.218  4.765   38.662  1.00 74.70  ? 602 CIT A C3  1 
HETATM 8169 O O7  . CIT H 7 .   ? 15.596  5.085   39.982  1.00 91.57  ? 602 CIT A O7  1 
HETATM 8170 C C4  . CIT H 7 .   ? 15.412  3.254   38.424  1.00 80.98  ? 602 CIT A C4  1 
HETATM 8171 C C5  . CIT H 7 .   ? 16.801  2.675   38.747  1.00 77.60  ? 602 CIT A C5  1 
HETATM 8172 O O3  . CIT H 7 .   ? 17.810  3.230   38.280  1.00 64.95  ? 602 CIT A O3  1 
HETATM 8173 O O4  . CIT H 7 .   ? 16.823  1.642   39.479  1.00 79.77  ? 602 CIT A O4  1 
HETATM 8174 C C6  . CIT H 7 .   ? 16.023  5.570   37.583  1.00 71.58  ? 602 CIT A C6  1 
HETATM 8175 O O5  . CIT H 7 .   ? 17.156  5.979   37.925  1.00 78.85  ? 602 CIT A O5  1 
HETATM 8176 O O6  . CIT H 7 .   ? 15.506  5.751   36.464  1.00 81.38  ? 602 CIT A O6  1 
HETATM 8177 C C1  . CIT I 7 .   ? -28.747 25.940  26.598  1.00 73.89  ? 603 CIT A C1  1 
HETATM 8178 O O1  . CIT I 7 .   ? -27.506 25.907  26.432  1.00 75.80  ? 603 CIT A O1  1 
HETATM 8179 O O2  . CIT I 7 .   ? -29.336 26.631  27.459  1.00 65.64  ? 603 CIT A O2  1 
HETATM 8180 C C2  . CIT I 7 .   ? -29.597 25.043  25.670  1.00 67.37  ? 603 CIT A C2  1 
HETATM 8181 C C3  . CIT I 7 .   ? -30.945 25.597  25.159  1.00 83.35  ? 603 CIT A C3  1 
HETATM 8182 O O7  . CIT I 7 .   ? -31.384 24.701  24.162  1.00 83.21  ? 603 CIT A O7  1 
HETATM 8183 C C4  . CIT I 7 .   ? -32.019 25.692  26.264  1.00 80.92  ? 603 CIT A C4  1 
HETATM 8184 C C5  . CIT I 7 .   ? -33.470 25.519  25.788  1.00 89.47  ? 603 CIT A C5  1 
HETATM 8185 O O3  . CIT I 7 .   ? -33.764 25.920  24.652  1.00 87.86  ? 603 CIT A O3  1 
HETATM 8186 O O4  . CIT I 7 .   ? -34.281 24.974  26.594  1.00 74.05  ? 603 CIT A O4  1 
HETATM 8187 C C6  . CIT I 7 .   ? -30.681 27.018  24.568  1.00 87.20  ? 603 CIT A C6  1 
HETATM 8188 O O5  . CIT I 7 .   ? -30.334 27.058  23.364  1.00 75.40  ? 603 CIT A O5  1 
HETATM 8189 O O6  . CIT I 7 .   ? -30.828 27.999  25.320  1.00 90.46  ? 603 CIT A O6  1 
HETATM 8190 O O   . HOH J 8 .   ? 20.632  -2.362  38.294  1.00 37.64  ? 701 HOH A O   1 
HETATM 8191 O O   . HOH K 8 .   ? -54.519 -24.581 32.562  1.00 35.16  ? 301 HOH G O   1 
HETATM 8192 O O   . HOH K 8 .   ? -50.841 -19.707 44.864  1.00 47.79  ? 302 HOH G O   1 
HETATM 8193 O O   . HOH L 8 .   ? 18.101  -23.656 13.752  1.00 28.07  ? 301 HOH H O   1 
HETATM 8194 O O   . HOH L 8 .   ? 11.304  -14.520 0.463   1.00 28.51  ? 302 HOH H O   1 
HETATM 8195 O O   . HOH M 8 .   ? 13.094  -36.763 -8.706  1.00 43.23  ? 301 HOH L O   1 
HETATM 8196 O O   . HOH M 8 .   ? 19.573  -14.607 -3.279  1.00 29.76  ? 302 HOH L O   1 
# 
