data_9CMX
# 
_entry.id   9CMX 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9CMX         pdb_00009cmx 10.2210/pdb9cmx/pdb 
WWPDB D_1000285567 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9CMX 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-15 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 9CEI unspecified 
PDB . 9CFI unspecified 
PDB . 9CFM unspecified 
PDB . 9CFO unspecified 
PDB . 9CFQ unspecified 
PDB . 9CGA unspecified 
PDB . 9CGB unspecified 
PDB . 9CGD unspecified 
PDB . 9CGE unspecified 
PDB . 9CGF unspecified 
PDB . 9CGG unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              mwilson13@unl.edu 
_pdbx_contact_author.name_first         Mark 
_pdbx_contact_author.name_last          Wilson 
_pdbx_contact_author.name_mi            A 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6317-900X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zielinski, K.'  1  ? 
'Dolamore, C.'   2  ? 
'Dalton, K.'     3  ? 
'Meisburger, S.' 4  ? 
'Smith, N.'      5  ? 
'Termini, J.'    6  ? 
'Henning, R.'    7  ? 
'Srajer, V.'     8  ? 
'Hekstra, D.'    9  ? 
'Pollack, L.'    10 ? 
'Wilson, M.A.'   11 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2024.07.19.604369 
_citation.pdbx_database_id_PubMed   39071394 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zielinski, K.A.' 1  ?                   
primary 'Dolamore, C.'    2  ?                   
primary 'Dalton, K.M.'    3  ?                   
primary 'Smith, N.'       4  ?                   
primary 'Termini, J.'     5  ?                   
primary 'Henning, R.'     6  ?                   
primary 'Srajer, V.'      7  ?                   
primary 'Hekstra, D.R.'   8  ?                   
primary 'Pollack, L.'     9  0000-0002-9366-4396 
primary 'Wilson, M.A.'    10 0000-0001-6317-900X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Parkinson disease protein 7' 20215.328 1   3.1.2.-,3.5.1.-,3.5.1.124 ? ? ? 
2 water   nat water                         18.015    102 ?                         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'Maillard deglycase,Oncogene DJ1,Parkinsonism-associated deglycase,Protein DJ-1,DJ-1,Protein/nucleic acid deglycase DJ-1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       
;GSHMASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNL
GAQNLSESAAVKEILKEQENRKGLIAAI(CSO)AGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLIL
TSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSHMASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNL
GAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRG
PGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   HIS n 
1 4   MET n 
1 5   ALA n 
1 6   SER n 
1 7   LYS n 
1 8   ARG n 
1 9   ALA n 
1 10  LEU n 
1 11  VAL n 
1 12  ILE n 
1 13  LEU n 
1 14  ALA n 
1 15  LYS n 
1 16  GLY n 
1 17  ALA n 
1 18  GLU n 
1 19  GLU n 
1 20  MET n 
1 21  GLU n 
1 22  THR n 
1 23  VAL n 
1 24  ILE n 
1 25  PRO n 
1 26  VAL n 
1 27  ASP n 
1 28  VAL n 
1 29  MET n 
1 30  ARG n 
1 31  ARG n 
1 32  ALA n 
1 33  GLY n 
1 34  ILE n 
1 35  LYS n 
1 36  VAL n 
1 37  THR n 
1 38  VAL n 
1 39  ALA n 
1 40  GLY n 
1 41  LEU n 
1 42  ALA n 
1 43  GLY n 
1 44  LYS n 
1 45  ASP n 
1 46  PRO n 
1 47  VAL n 
1 48  GLN n 
1 49  CYS n 
1 50  SER n 
1 51  ARG n 
1 52  ASP n 
1 53  VAL n 
1 54  VAL n 
1 55  ILE n 
1 56  CYS n 
1 57  PRO n 
1 58  ASP n 
1 59  ALA n 
1 60  SER n 
1 61  LEU n 
1 62  GLU n 
1 63  ASP n 
1 64  ALA n 
1 65  LYS n 
1 66  LYS n 
1 67  GLU n 
1 68  GLY n 
1 69  PRO n 
1 70  TYR n 
1 71  ASP n 
1 72  VAL n 
1 73  VAL n 
1 74  VAL n 
1 75  LEU n 
1 76  PRO n 
1 77  GLY n 
1 78  GLY n 
1 79  ASN n 
1 80  LEU n 
1 81  GLY n 
1 82  ALA n 
1 83  GLN n 
1 84  ASN n 
1 85  LEU n 
1 86  SER n 
1 87  GLU n 
1 88  SER n 
1 89  ALA n 
1 90  ALA n 
1 91  VAL n 
1 92  LYS n 
1 93  GLU n 
1 94  ILE n 
1 95  LEU n 
1 96  LYS n 
1 97  GLU n 
1 98  GLN n 
1 99  GLU n 
1 100 ASN n 
1 101 ARG n 
1 102 LYS n 
1 103 GLY n 
1 104 LEU n 
1 105 ILE n 
1 106 ALA n 
1 107 ALA n 
1 108 ILE n 
1 109 CSO n 
1 110 ALA n 
1 111 GLY n 
1 112 PRO n 
1 113 THR n 
1 114 ALA n 
1 115 LEU n 
1 116 LEU n 
1 117 ALA n 
1 118 HIS n 
1 119 GLU n 
1 120 ILE n 
1 121 GLY n 
1 122 PHE n 
1 123 GLY n 
1 124 SER n 
1 125 LYS n 
1 126 VAL n 
1 127 THR n 
1 128 THR n 
1 129 HIS n 
1 130 PRO n 
1 131 LEU n 
1 132 ALA n 
1 133 LYS n 
1 134 ASP n 
1 135 LYS n 
1 136 MET n 
1 137 MET n 
1 138 ASN n 
1 139 GLY n 
1 140 GLY n 
1 141 HIS n 
1 142 TYR n 
1 143 THR n 
1 144 TYR n 
1 145 SER n 
1 146 GLU n 
1 147 ASN n 
1 148 ARG n 
1 149 VAL n 
1 150 GLU n 
1 151 LYS n 
1 152 ASP n 
1 153 GLY n 
1 154 LEU n 
1 155 ILE n 
1 156 LEU n 
1 157 THR n 
1 158 SER n 
1 159 ARG n 
1 160 GLY n 
1 161 PRO n 
1 162 GLY n 
1 163 THR n 
1 164 SER n 
1 165 PHE n 
1 166 GLU n 
1 167 PHE n 
1 168 ALA n 
1 169 LEU n 
1 170 ALA n 
1 171 ILE n 
1 172 VAL n 
1 173 GLU n 
1 174 ALA n 
1 175 LEU n 
1 176 ASN n 
1 177 GLY n 
1 178 LYS n 
1 179 GLU n 
1 180 VAL n 
1 181 ALA n 
1 182 ALA n 
1 183 GLN n 
1 184 VAL n 
1 185 LYS n 
1 186 ALA n 
1 187 PRO n 
1 188 LEU n 
1 189 VAL n 
1 190 LEU n 
1 191 LYS n 
1 192 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   192 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PARK7 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET15b 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE           ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE          ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE        ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'   ? 'C4 H7 N O4'     133.103 
CSO 'L-peptide linking' n S-HYDROXYCYSTEINE ? 'C3 H7 N O3 S'   137.158 
CYS 'L-peptide linking' y CYSTEINE          ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE         ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'   ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE           ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE         ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER             ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE        ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE           ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE            ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE        ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE     ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE           ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE            ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE         ? 'C4 H9 N O3'     119.119 
TYR 'L-peptide linking' y TYROSINE          ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE            ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -2  ?   ?   ?   A . n 
A 1 2   SER 2   -1  ?   ?   ?   A . n 
A 1 3   HIS 3   0   ?   ?   ?   A . n 
A 1 4   MET 4   1   ?   ?   ?   A . n 
A 1 5   ALA 5   2   2   ALA ALA A . n 
A 1 6   SER 6   3   3   SER SER A . n 
A 1 7   LYS 7   4   4   LYS LYS A . n 
A 1 8   ARG 8   5   5   ARG ARG A . n 
A 1 9   ALA 9   6   6   ALA ALA A . n 
A 1 10  LEU 10  7   7   LEU LEU A . n 
A 1 11  VAL 11  8   8   VAL VAL A . n 
A 1 12  ILE 12  9   9   ILE ILE A . n 
A 1 13  LEU 13  10  10  LEU LEU A . n 
A 1 14  ALA 14  11  11  ALA ALA A . n 
A 1 15  LYS 15  12  12  LYS LYS A . n 
A 1 16  GLY 16  13  13  GLY GLY A . n 
A 1 17  ALA 17  14  14  ALA ALA A . n 
A 1 18  GLU 18  15  15  GLU GLU A . n 
A 1 19  GLU 19  16  16  GLU GLU A . n 
A 1 20  MET 20  17  17  MET MET A . n 
A 1 21  GLU 21  18  18  GLU GLU A . n 
A 1 22  THR 22  19  19  THR THR A . n 
A 1 23  VAL 23  20  20  VAL VAL A . n 
A 1 24  ILE 24  21  21  ILE ILE A . n 
A 1 25  PRO 25  22  22  PRO PRO A . n 
A 1 26  VAL 26  23  23  VAL VAL A . n 
A 1 27  ASP 27  24  24  ASP ASP A . n 
A 1 28  VAL 28  25  25  VAL VAL A . n 
A 1 29  MET 29  26  26  MET MET A . n 
A 1 30  ARG 30  27  27  ARG ARG A . n 
A 1 31  ARG 31  28  28  ARG ARG A . n 
A 1 32  ALA 32  29  29  ALA ALA A . n 
A 1 33  GLY 33  30  30  GLY GLY A . n 
A 1 34  ILE 34  31  31  ILE ILE A . n 
A 1 35  LYS 35  32  32  LYS LYS A . n 
A 1 36  VAL 36  33  33  VAL VAL A . n 
A 1 37  THR 37  34  34  THR THR A . n 
A 1 38  VAL 38  35  35  VAL VAL A . n 
A 1 39  ALA 39  36  36  ALA ALA A . n 
A 1 40  GLY 40  37  37  GLY GLY A . n 
A 1 41  LEU 41  38  38  LEU LEU A . n 
A 1 42  ALA 42  39  39  ALA ALA A . n 
A 1 43  GLY 43  40  40  GLY GLY A . n 
A 1 44  LYS 44  41  41  LYS LYS A . n 
A 1 45  ASP 45  42  42  ASP ASP A . n 
A 1 46  PRO 46  43  43  PRO PRO A . n 
A 1 47  VAL 47  44  44  VAL VAL A . n 
A 1 48  GLN 48  45  45  GLN GLN A . n 
A 1 49  CYS 49  46  46  CYS CYS A . n 
A 1 50  SER 50  47  47  SER SER A . n 
A 1 51  ARG 51  48  48  ARG ARG A . n 
A 1 52  ASP 52  49  49  ASP ASP A . n 
A 1 53  VAL 53  50  50  VAL VAL A . n 
A 1 54  VAL 54  51  51  VAL VAL A . n 
A 1 55  ILE 55  52  52  ILE ILE A . n 
A 1 56  CYS 56  53  53  CYS CYS A . n 
A 1 57  PRO 57  54  54  PRO PRO A . n 
A 1 58  ASP 58  55  55  ASP ASP A . n 
A 1 59  ALA 59  56  56  ALA ALA A . n 
A 1 60  SER 60  57  57  SER SER A . n 
A 1 61  LEU 61  58  58  LEU LEU A . n 
A 1 62  GLU 62  59  59  GLU GLU A . n 
A 1 63  ASP 63  60  60  ASP ASP A . n 
A 1 64  ALA 64  61  61  ALA ALA A . n 
A 1 65  LYS 65  62  62  LYS LYS A . n 
A 1 66  LYS 66  63  63  LYS LYS A . n 
A 1 67  GLU 67  64  64  GLU GLU A . n 
A 1 68  GLY 68  65  65  GLY GLY A . n 
A 1 69  PRO 69  66  66  PRO PRO A . n 
A 1 70  TYR 70  67  67  TYR TYR A . n 
A 1 71  ASP 71  68  68  ASP ASP A . n 
A 1 72  VAL 72  69  69  VAL VAL A . n 
A 1 73  VAL 73  70  70  VAL VAL A . n 
A 1 74  VAL 74  71  71  VAL VAL A . n 
A 1 75  LEU 75  72  72  LEU LEU A . n 
A 1 76  PRO 76  73  73  PRO PRO A . n 
A 1 77  GLY 77  74  74  GLY GLY A . n 
A 1 78  GLY 78  75  75  GLY GLY A . n 
A 1 79  ASN 79  76  76  ASN ASN A . n 
A 1 80  LEU 80  77  77  LEU LEU A . n 
A 1 81  GLY 81  78  78  GLY GLY A . n 
A 1 82  ALA 82  79  79  ALA ALA A . n 
A 1 83  GLN 83  80  80  GLN GLN A . n 
A 1 84  ASN 84  81  81  ASN ASN A . n 
A 1 85  LEU 85  82  82  LEU LEU A . n 
A 1 86  SER 86  83  83  SER SER A . n 
A 1 87  GLU 87  84  84  GLU GLU A . n 
A 1 88  SER 88  85  85  SER SER A . n 
A 1 89  ALA 89  86  86  ALA ALA A . n 
A 1 90  ALA 90  87  87  ALA ALA A . n 
A 1 91  VAL 91  88  88  VAL VAL A . n 
A 1 92  LYS 92  89  89  LYS LYS A . n 
A 1 93  GLU 93  90  90  GLU GLU A . n 
A 1 94  ILE 94  91  91  ILE ILE A . n 
A 1 95  LEU 95  92  92  LEU LEU A . n 
A 1 96  LYS 96  93  93  LYS LYS A . n 
A 1 97  GLU 97  94  94  GLU GLU A . n 
A 1 98  GLN 98  95  95  GLN GLN A . n 
A 1 99  GLU 99  96  96  GLU GLU A . n 
A 1 100 ASN 100 97  97  ASN ASN A . n 
A 1 101 ARG 101 98  98  ARG ARG A . n 
A 1 102 LYS 102 99  99  LYS LYS A . n 
A 1 103 GLY 103 100 100 GLY GLY A . n 
A 1 104 LEU 104 101 101 LEU LEU A . n 
A 1 105 ILE 105 102 102 ILE ILE A . n 
A 1 106 ALA 106 103 103 ALA ALA A . n 
A 1 107 ALA 107 104 104 ALA ALA A . n 
A 1 108 ILE 108 105 105 ILE ILE A . n 
A 1 109 CSO 109 106 106 CSO CSO A . n 
A 1 110 ALA 110 107 107 ALA ALA A . n 
A 1 111 GLY 111 108 108 GLY GLY A . n 
A 1 112 PRO 112 109 109 PRO PRO A . n 
A 1 113 THR 113 110 110 THR THR A . n 
A 1 114 ALA 114 111 111 ALA ALA A . n 
A 1 115 LEU 115 112 112 LEU LEU A . n 
A 1 116 LEU 116 113 113 LEU LEU A . n 
A 1 117 ALA 117 114 114 ALA ALA A . n 
A 1 118 HIS 118 115 115 HIS HIS A . n 
A 1 119 GLU 119 116 116 GLU GLU A . n 
A 1 120 ILE 120 117 117 ILE ILE A . n 
A 1 121 GLY 121 118 118 GLY GLY A . n 
A 1 122 PHE 122 119 119 PHE PHE A . n 
A 1 123 GLY 123 120 120 GLY GLY A . n 
A 1 124 SER 124 121 121 SER SER A . n 
A 1 125 LYS 125 122 122 LYS LYS A . n 
A 1 126 VAL 126 123 123 VAL VAL A . n 
A 1 127 THR 127 124 124 THR THR A . n 
A 1 128 THR 128 125 125 THR THR A . n 
A 1 129 HIS 129 126 126 HIS HIS A . n 
A 1 130 PRO 130 127 127 PRO PRO A . n 
A 1 131 LEU 131 128 128 LEU LEU A . n 
A 1 132 ALA 132 129 129 ALA ALA A . n 
A 1 133 LYS 133 130 130 LYS LYS A . n 
A 1 134 ASP 134 131 131 ASP ASP A . n 
A 1 135 LYS 135 132 132 LYS LYS A . n 
A 1 136 MET 136 133 133 MET MET A . n 
A 1 137 MET 137 134 134 MET MET A . n 
A 1 138 ASN 138 135 135 ASN ASN A . n 
A 1 139 GLY 139 136 136 GLY GLY A . n 
A 1 140 GLY 140 137 137 GLY GLY A . n 
A 1 141 HIS 141 138 138 HIS HIS A . n 
A 1 142 TYR 142 139 139 TYR TYR A . n 
A 1 143 THR 143 140 140 THR THR A . n 
A 1 144 TYR 144 141 141 TYR TYR A . n 
A 1 145 SER 145 142 142 SER SER A . n 
A 1 146 GLU 146 143 143 GLU GLU A . n 
A 1 147 ASN 147 144 144 ASN ASN A . n 
A 1 148 ARG 148 145 145 ARG ARG A . n 
A 1 149 VAL 149 146 146 VAL VAL A . n 
A 1 150 GLU 150 147 147 GLU GLU A . n 
A 1 151 LYS 151 148 148 LYS LYS A . n 
A 1 152 ASP 152 149 149 ASP ASP A . n 
A 1 153 GLY 153 150 150 GLY GLY A . n 
A 1 154 LEU 154 151 151 LEU LEU A . n 
A 1 155 ILE 155 152 152 ILE ILE A . n 
A 1 156 LEU 156 153 153 LEU LEU A . n 
A 1 157 THR 157 154 154 THR THR A . n 
A 1 158 SER 158 155 155 SER SER A . n 
A 1 159 ARG 159 156 156 ARG ARG A . n 
A 1 160 GLY 160 157 157 GLY GLY A . n 
A 1 161 PRO 161 158 158 PRO PRO A . n 
A 1 162 GLY 162 159 159 GLY GLY A . n 
A 1 163 THR 163 160 160 THR THR A . n 
A 1 164 SER 164 161 161 SER SER A . n 
A 1 165 PHE 165 162 162 PHE PHE A . n 
A 1 166 GLU 166 163 163 GLU GLU A . n 
A 1 167 PHE 167 164 164 PHE PHE A . n 
A 1 168 ALA 168 165 165 ALA ALA A . n 
A 1 169 LEU 169 166 166 LEU LEU A . n 
A 1 170 ALA 170 167 167 ALA ALA A . n 
A 1 171 ILE 171 168 168 ILE ILE A . n 
A 1 172 VAL 172 169 169 VAL VAL A . n 
A 1 173 GLU 173 170 170 GLU GLU A . n 
A 1 174 ALA 174 171 171 ALA ALA A . n 
A 1 175 LEU 175 172 172 LEU LEU A . n 
A 1 176 ASN 176 173 173 ASN ASN A . n 
A 1 177 GLY 177 174 174 GLY GLY A . n 
A 1 178 LYS 178 175 175 LYS LYS A . n 
A 1 179 GLU 179 176 176 GLU GLU A . n 
A 1 180 VAL 180 177 177 VAL VAL A . n 
A 1 181 ALA 181 178 178 ALA ALA A . n 
A 1 182 ALA 182 179 179 ALA ALA A . n 
A 1 183 GLN 183 180 180 GLN GLN A . n 
A 1 184 VAL 184 181 181 VAL VAL A . n 
A 1 185 LYS 185 182 182 LYS LYS A . n 
A 1 186 ALA 186 183 183 ALA ALA A . n 
A 1 187 PRO 187 184 184 PRO PRO A . n 
A 1 188 LEU 188 185 185 LEU LEU A . n 
A 1 189 VAL 189 186 186 VAL VAL A . n 
A 1 190 LEU 190 187 187 LEU LEU A . n 
A 1 191 LYS 191 188 188 LYS LYS A . n 
A 1 192 ASP 192 189 189 ASP ASP A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   201 104 HOH HOH A . 
B 2 HOH 2   202 100 HOH HOH A . 
B 2 HOH 3   203 73  HOH HOH A . 
B 2 HOH 4   204 71  HOH HOH A . 
B 2 HOH 5   205 99  HOH HOH A . 
B 2 HOH 6   206 76  HOH HOH A . 
B 2 HOH 7   207 43  HOH HOH A . 
B 2 HOH 8   208 24  HOH HOH A . 
B 2 HOH 9   209 31  HOH HOH A . 
B 2 HOH 10  210 11  HOH HOH A . 
B 2 HOH 11  211 48  HOH HOH A . 
B 2 HOH 12  212 29  HOH HOH A . 
B 2 HOH 13  213 26  HOH HOH A . 
B 2 HOH 14  214 83  HOH HOH A . 
B 2 HOH 15  215 14  HOH HOH A . 
B 2 HOH 16  216 12  HOH HOH A . 
B 2 HOH 17  217 27  HOH HOH A . 
B 2 HOH 18  218 105 HOH HOH A . 
B 2 HOH 19  219 7   HOH HOH A . 
B 2 HOH 20  220 22  HOH HOH A . 
B 2 HOH 21  221 90  HOH HOH A . 
B 2 HOH 22  222 53  HOH HOH A . 
B 2 HOH 23  223 37  HOH HOH A . 
B 2 HOH 24  224 4   HOH HOH A . 
B 2 HOH 25  225 6   HOH HOH A . 
B 2 HOH 26  226 8   HOH HOH A . 
B 2 HOH 27  227 28  HOH HOH A . 
B 2 HOH 28  228 51  HOH HOH A . 
B 2 HOH 29  229 63  HOH HOH A . 
B 2 HOH 30  230 38  HOH HOH A . 
B 2 HOH 31  231 10  HOH HOH A . 
B 2 HOH 32  232 46  HOH HOH A . 
B 2 HOH 33  233 74  HOH HOH A . 
B 2 HOH 34  234 82  HOH HOH A . 
B 2 HOH 35  235 80  HOH HOH A . 
B 2 HOH 36  236 36  HOH HOH A . 
B 2 HOH 37  237 18  HOH HOH A . 
B 2 HOH 38  238 60  HOH HOH A . 
B 2 HOH 39  239 56  HOH HOH A . 
B 2 HOH 40  240 49  HOH HOH A . 
B 2 HOH 41  241 1   HOH HOH A . 
B 2 HOH 42  242 77  HOH HOH A . 
B 2 HOH 43  243 23  HOH HOH A . 
B 2 HOH 44  244 72  HOH HOH A . 
B 2 HOH 45  245 34  HOH HOH A . 
B 2 HOH 46  246 5   HOH HOH A . 
B 2 HOH 47  247 32  HOH HOH A . 
B 2 HOH 48  248 15  HOH HOH A . 
B 2 HOH 49  249 20  HOH HOH A . 
B 2 HOH 50  250 87  HOH HOH A . 
B 2 HOH 51  251 62  HOH HOH A . 
B 2 HOH 52  252 58  HOH HOH A . 
B 2 HOH 53  253 3   HOH HOH A . 
B 2 HOH 54  254 64  HOH HOH A . 
B 2 HOH 55  255 25  HOH HOH A . 
B 2 HOH 56  256 52  HOH HOH A . 
B 2 HOH 57  257 45  HOH HOH A . 
B 2 HOH 58  258 67  HOH HOH A . 
B 2 HOH 59  259 84  HOH HOH A . 
B 2 HOH 60  260 16  HOH HOH A . 
B 2 HOH 61  261 40  HOH HOH A . 
B 2 HOH 62  262 69  HOH HOH A . 
B 2 HOH 63  263 75  HOH HOH A . 
B 2 HOH 64  264 98  HOH HOH A . 
B 2 HOH 65  265 97  HOH HOH A . 
B 2 HOH 66  266 89  HOH HOH A . 
B 2 HOH 67  267 13  HOH HOH A . 
B 2 HOH 68  268 9   HOH HOH A . 
B 2 HOH 69  269 33  HOH HOH A . 
B 2 HOH 70  270 54  HOH HOH A . 
B 2 HOH 71  271 79  HOH HOH A . 
B 2 HOH 72  272 88  HOH HOH A . 
B 2 HOH 73  273 42  HOH HOH A . 
B 2 HOH 74  274 17  HOH HOH A . 
B 2 HOH 75  275 55  HOH HOH A . 
B 2 HOH 76  276 66  HOH HOH A . 
B 2 HOH 77  277 2   HOH HOH A . 
B 2 HOH 78  278 101 HOH HOH A . 
B 2 HOH 79  279 65  HOH HOH A . 
B 2 HOH 80  280 21  HOH HOH A . 
B 2 HOH 81  281 78  HOH HOH A . 
B 2 HOH 82  282 50  HOH HOH A . 
B 2 HOH 83  283 41  HOH HOH A . 
B 2 HOH 84  284 95  HOH HOH A . 
B 2 HOH 85  285 35  HOH HOH A . 
B 2 HOH 86  286 86  HOH HOH A . 
B 2 HOH 87  287 68  HOH HOH A . 
B 2 HOH 88  288 61  HOH HOH A . 
B 2 HOH 89  289 70  HOH HOH A . 
B 2 HOH 90  290 93  HOH HOH A . 
B 2 HOH 91  291 39  HOH HOH A . 
B 2 HOH 92  292 47  HOH HOH A . 
B 2 HOH 93  293 92  HOH HOH A . 
B 2 HOH 94  294 57  HOH HOH A . 
B 2 HOH 95  295 102 HOH HOH A . 
B 2 HOH 96  296 19  HOH HOH A . 
B 2 HOH 97  297 103 HOH HOH A . 
B 2 HOH 98  298 96  HOH HOH A . 
B 2 HOH 99  299 94  HOH HOH A . 
B 2 HOH 100 300 44  HOH HOH A . 
B 2 HOH 101 301 85  HOH HOH A . 
B 2 HOH 102 302 91  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? DIALS  ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? DIALS  ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.19.2_4158 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9CMX 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     76.327 
_cell.length_a_esd                 ? 
_cell.length_b                     76.327 
_cell.length_b_esd                 ? 
_cell.length_c                     76.452 
_cell.length_c_esd                 ? 
_cell.volume                       385724.303 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9CMX 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9CMX 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.18 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          61.32 
_exptl_crystal.description                  '20-25 micron microcrystals' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES, 200 mM NaCl, 15% (w/v) PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     293 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   Y 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER2 X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2024-02-11 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.969 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'CHESS BEAMLINE 7B2' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.969 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   7B2 
_diffrn_source.pdbx_synchrotron_site       CHESS 
# 
_reflns.B_iso_Wilson_estimate                          25.09 
_reflns.entry_id                                       9CMX 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.63 
_reflns.d_resolution_low                               66.10 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     32118 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.61 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                11.4 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          8.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.990 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.224 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.63 
_reflns_shell.d_res_low                                     1.66 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.7 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1632 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               11.5 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.26 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.69 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  4.819 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               31.30 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9CMX 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.63 
_refine.ls_d_res_low                             50.00 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     31969 
_refine.ls_number_reflns_R_free                  2005 
_refine.ls_number_reflns_R_work                  29964 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.16 
_refine.ls_percent_reflns_R_free                 6.27 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1459 
_refine.ls_R_factor_R_free                       0.1681 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1444 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.33 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'FOURIER SYNTHESIS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.1609 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2213 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.63 
_refine_hist.d_res_low                        50.00 
_refine_hist.number_atoms_solvent             102 
_refine_hist.number_atoms_total               1486 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1384 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0115  ? 1499 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1397  ? 2037 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0668  ? 239  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0088  ? 269  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.2310 ? 582  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.63 1.67  . . 135 2092 97.38 . . . . 0.3147 . . . . . . . . . . . 0.3157 
'X-RAY DIFFRACTION' 1.67 1.72  . . 137 2101 98.11 . . . . 0.2753 . . . . . . . . . . . 0.3330 
'X-RAY DIFFRACTION' 1.72 1.77  . . 132 2124 98.52 . . . . 0.2537 . . . . . . . . . . . 0.2946 
'X-RAY DIFFRACTION' 1.77 1.82  . . 129 2160 98.45 . . . . 0.2219 . . . . . . . . . . . 0.2442 
'X-RAY DIFFRACTION' 1.82 1.89  . . 136 2149 99.39 . . . . 0.1993 . . . . . . . . . . . 0.2274 
'X-RAY DIFFRACTION' 1.89 1.96  . . 162 2131 99.01 . . . . 0.2043 . . . . . . . . . . . 0.2464 
'X-RAY DIFFRACTION' 1.96 2.05  . . 138 2124 99.25 . . . . 0.1536 . . . . . . . . . . . 0.2010 
'X-RAY DIFFRACTION' 2.05 2.16  . . 142 2158 98.80 . . . . 0.1415 . . . . . . . . . . . 0.1694 
'X-RAY DIFFRACTION' 2.16 2.30  . . 152 2164 99.06 . . . . 0.1263 . . . . . . . . . . . 0.1492 
'X-RAY DIFFRACTION' 2.30 2.47  . . 159 2100 98.26 . . . . 0.1320 . . . . . . . . . . . 0.1511 
'X-RAY DIFFRACTION' 2.47 2.72  . . 133 2159 97.95 . . . . 0.1402 . . . . . . . . . . . 0.1670 
'X-RAY DIFFRACTION' 2.72 3.12  . . 159 2136 98.16 . . . . 0.1379 . . . . . . . . . . . 0.1377 
'X-RAY DIFFRACTION' 3.12 3.93  . . 158 2143 97.17 . . . . 0.1275 . . . . . . . . . . . 0.1500 
'X-RAY DIFFRACTION' 3.93 50.00 . . 133 2223 95.04 . . . . 0.1157 . . . . . . . . . . . 0.1448 
# 
_struct.entry_id                     9CMX 
_struct.title                        'Human DJ-1, fixed target serial crystallography' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9CMX 
_struct_keywords.text            'Glutathione-independent glyoxalase, fixed target, microcrystals, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PARK7_HUMAN 
_struct_ref.pdbx_db_accession          Q99497 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQ
NLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGT
SFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9CMX 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 4 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 192 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q99497 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  189 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       189 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9CMX GLY A 1 ? UNP Q99497 ? ? 'expression tag' -2 1 
1 9CMX SER A 2 ? UNP Q99497 ? ? 'expression tag' -1 2 
1 9CMX HIS A 3 ? UNP Q99497 ? ? 'expression tag' 0  3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2770  ? 
1 MORE         -19   ? 
1 'SSA (A^2)'  15250 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z         1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 5_555 x-y,-y,-z+2/3 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 50.9680000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 18  ? ALA A 32  ? GLU A 15  ALA A 29  1 ? 15 
HELX_P HELX_P2  AA2 LEU A 61  ? GLU A 67  ? LEU A 58  GLU A 64  1 ? 7  
HELX_P HELX_P3  AA3 GLY A 78  ? GLU A 87  ? GLY A 75  GLU A 84  1 ? 10 
HELX_P HELX_P4  AA4 SER A 88  ? LYS A 102 ? SER A 85  LYS A 99  1 ? 15 
HELX_P HELX_P5  AA5 PRO A 112 ? HIS A 118 ? PRO A 109 HIS A 115 1 ? 7  
HELX_P HELX_P6  AA6 HIS A 129 ? LEU A 131 ? HIS A 126 LEU A 128 5 ? 3  
HELX_P HELX_P7  AA7 ALA A 132 ? MET A 137 ? ALA A 129 MET A 134 1 ? 6  
HELX_P HELX_P8  AA8 GLY A 160 ? GLY A 162 ? GLY A 157 GLY A 159 5 ? 3  
HELX_P HELX_P9  AA9 THR A 163 ? GLY A 177 ? THR A 160 GLY A 174 1 ? 15 
HELX_P HELX_P10 AB1 GLY A 177 ? ALA A 186 ? GLY A 174 ALA A 183 1 ? 10 
HELX_P HELX_P11 AB2 PRO A 187 ? VAL A 189 ? PRO A 184 VAL A 186 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A ILE 108 C ? ? ? 1_555 A CSO 109 N ? ? A ILE 105 A CSO 106 1_555 ? ? ? ? ? ? ? 1.355 ? ? 
covale2 covale both ? A CSO 109 C ? ? ? 1_555 A ALA 110 N ? ? A CSO 106 A ALA 107 1_555 ? ? ? ? ? ? ? 1.342 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CSO 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       109 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     . 
_pdbx_modification_feature.modified_residue_label_asym_id     . 
_pdbx_modification_feature.modified_residue_label_seq_id      . 
_pdbx_modification_feature.modified_residue_label_alt_id      . 
_pdbx_modification_feature.auth_comp_id                       CSO 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        106 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      . 
_pdbx_modification_feature.modified_residue_auth_asym_id      . 
_pdbx_modification_feature.modified_residue_auth_seq_id       . 
_pdbx_modification_feature.modified_residue_PDB_ins_code      . 
_pdbx_modification_feature.modified_residue_symmetry          . 
_pdbx_modification_feature.comp_id_linking_atom               . 
_pdbx_modification_feature.modified_residue_id_linking_atom   . 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        CSO 
_pdbx_modification_feature.type                               Hydroxylation 
_pdbx_modification_feature.category                           'Named protein modification' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           68 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            65 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    69 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     66 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -8.41 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 59  ? SER A 60  ? ALA A 56  SER A 57  
AA1 2 LYS A 35  ? GLY A 40  ? LYS A 32  GLY A 37  
AA1 3 ARG A 8   ? LEU A 13  ? ARG A 5   LEU A 10  
AA1 4 VAL A 72  ? LEU A 75  ? VAL A 69  LEU A 72  
AA1 5 LEU A 104 ? ILE A 108 ? LEU A 101 ILE A 105 
AA1 6 ILE A 155 ? SER A 158 ? ILE A 152 SER A 155 
AA1 7 VAL A 149 ? ASP A 152 ? VAL A 146 ASP A 149 
AA2 1 VAL A 47  ? GLN A 48  ? VAL A 44  GLN A 45  
AA2 2 VAL A 54  ? ILE A 55  ? VAL A 51  ILE A 52  
AA3 1 LYS A 125 ? VAL A 126 ? LYS A 122 VAL A 123 
AA3 2 THR A 143 ? TYR A 144 ? THR A 140 TYR A 141 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ALA A 59  ? O ALA A 56  N GLY A 40  ? N GLY A 37  
AA1 2 3 O ALA A 39  ? O ALA A 36  N LEU A 13  ? N LEU A 10  
AA1 3 4 N LEU A 10  ? N LEU A 7   O VAL A 74  ? O VAL A 71  
AA1 4 5 N LEU A 75  ? N LEU A 72  O ALA A 106 ? O ALA A 103 
AA1 5 6 N ILE A 105 ? N ILE A 102 O LEU A 156 ? O LEU A 153 
AA1 6 7 O THR A 157 ? O THR A 154 N GLU A 150 ? N GLU A 147 
AA2 1 2 N VAL A 47  ? N VAL A 44  O ILE A 55  ? O ILE A 52  
AA3 1 2 N VAL A 126 ? N VAL A 123 O THR A 143 ? O THR A 140 
# 
_pdbx_entry_details.entry_id                   9CMX 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 HD21 A ASN 76  ? B O A HOH 201 ? ? 1.51 
2 1 O    A HOH 278 ? ? O A HOH 297 ? ? 1.58 
3 1 ND2  A ASN 76  ? B O A HOH 201 ? ? 1.83 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    CSO 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     106 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             73.63 
_pdbx_validate_torsion.psi             -111.02 
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    A 
_pdbx_struct_mod_residue.label_comp_id    CSO 
_pdbx_struct_mod_residue.label_seq_id     109 
_pdbx_struct_mod_residue.auth_asym_id     A 
_pdbx_struct_mod_residue.auth_comp_id     CSO 
_pdbx_struct_mod_residue.auth_seq_id      106 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   CYS 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY -2 ? A GLY 1 
2 1 Y 1 A SER -1 ? A SER 2 
3 1 Y 1 A HIS 0  ? A HIS 3 
4 1 Y 1 A MET 1  ? A MET 4 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CSO N    N N N 74  
CSO CA   C N R 75  
CSO CB   C N N 76  
CSO SG   S N N 77  
CSO C    C N N 78  
CSO O    O N N 79  
CSO OXT  O N N 80  
CSO OD   O N N 81  
CSO H    H N N 82  
CSO H2   H N N 83  
CSO HA   H N N 84  
CSO HB2  H N N 85  
CSO HB3  H N N 86  
CSO HXT  H N N 87  
CSO HD   H N N 88  
CYS N    N N N 89  
CYS CA   C N R 90  
CYS C    C N N 91  
CYS O    O N N 92  
CYS CB   C N N 93  
CYS SG   S N N 94  
CYS OXT  O N N 95  
CYS H    H N N 96  
CYS H2   H N N 97  
CYS HA   H N N 98  
CYS HB2  H N N 99  
CYS HB3  H N N 100 
CYS HG   H N N 101 
CYS HXT  H N N 102 
GLN N    N N N 103 
GLN CA   C N S 104 
GLN C    C N N 105 
GLN O    O N N 106 
GLN CB   C N N 107 
GLN CG   C N N 108 
GLN CD   C N N 109 
GLN OE1  O N N 110 
GLN NE2  N N N 111 
GLN OXT  O N N 112 
GLN H    H N N 113 
GLN H2   H N N 114 
GLN HA   H N N 115 
GLN HB2  H N N 116 
GLN HB3  H N N 117 
GLN HG2  H N N 118 
GLN HG3  H N N 119 
GLN HE21 H N N 120 
GLN HE22 H N N 121 
GLN HXT  H N N 122 
GLU N    N N N 123 
GLU CA   C N S 124 
GLU C    C N N 125 
GLU O    O N N 126 
GLU CB   C N N 127 
GLU CG   C N N 128 
GLU CD   C N N 129 
GLU OE1  O N N 130 
GLU OE2  O N N 131 
GLU OXT  O N N 132 
GLU H    H N N 133 
GLU H2   H N N 134 
GLU HA   H N N 135 
GLU HB2  H N N 136 
GLU HB3  H N N 137 
GLU HG2  H N N 138 
GLU HG3  H N N 139 
GLU HE2  H N N 140 
GLU HXT  H N N 141 
GLY N    N N N 142 
GLY CA   C N N 143 
GLY C    C N N 144 
GLY O    O N N 145 
GLY OXT  O N N 146 
GLY H    H N N 147 
GLY H2   H N N 148 
GLY HA2  H N N 149 
GLY HA3  H N N 150 
GLY HXT  H N N 151 
HIS N    N N N 152 
HIS CA   C N S 153 
HIS C    C N N 154 
HIS O    O N N 155 
HIS CB   C N N 156 
HIS CG   C Y N 157 
HIS ND1  N Y N 158 
HIS CD2  C Y N 159 
HIS CE1  C Y N 160 
HIS NE2  N Y N 161 
HIS OXT  O N N 162 
HIS H    H N N 163 
HIS H2   H N N 164 
HIS HA   H N N 165 
HIS HB2  H N N 166 
HIS HB3  H N N 167 
HIS HD1  H N N 168 
HIS HD2  H N N 169 
HIS HE1  H N N 170 
HIS HE2  H N N 171 
HIS HXT  H N N 172 
HOH O    O N N 173 
HOH H1   H N N 174 
HOH H2   H N N 175 
ILE N    N N N 176 
ILE CA   C N S 177 
ILE C    C N N 178 
ILE O    O N N 179 
ILE CB   C N S 180 
ILE CG1  C N N 181 
ILE CG2  C N N 182 
ILE CD1  C N N 183 
ILE OXT  O N N 184 
ILE H    H N N 185 
ILE H2   H N N 186 
ILE HA   H N N 187 
ILE HB   H N N 188 
ILE HG12 H N N 189 
ILE HG13 H N N 190 
ILE HG21 H N N 191 
ILE HG22 H N N 192 
ILE HG23 H N N 193 
ILE HD11 H N N 194 
ILE HD12 H N N 195 
ILE HD13 H N N 196 
ILE HXT  H N N 197 
LEU N    N N N 198 
LEU CA   C N S 199 
LEU C    C N N 200 
LEU O    O N N 201 
LEU CB   C N N 202 
LEU CG   C N N 203 
LEU CD1  C N N 204 
LEU CD2  C N N 205 
LEU OXT  O N N 206 
LEU H    H N N 207 
LEU H2   H N N 208 
LEU HA   H N N 209 
LEU HB2  H N N 210 
LEU HB3  H N N 211 
LEU HG   H N N 212 
LEU HD11 H N N 213 
LEU HD12 H N N 214 
LEU HD13 H N N 215 
LEU HD21 H N N 216 
LEU HD22 H N N 217 
LEU HD23 H N N 218 
LEU HXT  H N N 219 
LYS N    N N N 220 
LYS CA   C N S 221 
LYS C    C N N 222 
LYS O    O N N 223 
LYS CB   C N N 224 
LYS CG   C N N 225 
LYS CD   C N N 226 
LYS CE   C N N 227 
LYS NZ   N N N 228 
LYS OXT  O N N 229 
LYS H    H N N 230 
LYS H2   H N N 231 
LYS HA   H N N 232 
LYS HB2  H N N 233 
LYS HB3  H N N 234 
LYS HG2  H N N 235 
LYS HG3  H N N 236 
LYS HD2  H N N 237 
LYS HD3  H N N 238 
LYS HE2  H N N 239 
LYS HE3  H N N 240 
LYS HZ1  H N N 241 
LYS HZ2  H N N 242 
LYS HZ3  H N N 243 
LYS HXT  H N N 244 
MET N    N N N 245 
MET CA   C N S 246 
MET C    C N N 247 
MET O    O N N 248 
MET CB   C N N 249 
MET CG   C N N 250 
MET SD   S N N 251 
MET CE   C N N 252 
MET OXT  O N N 253 
MET H    H N N 254 
MET H2   H N N 255 
MET HA   H N N 256 
MET HB2  H N N 257 
MET HB3  H N N 258 
MET HG2  H N N 259 
MET HG3  H N N 260 
MET HE1  H N N 261 
MET HE2  H N N 262 
MET HE3  H N N 263 
MET HXT  H N N 264 
PHE N    N N N 265 
PHE CA   C N S 266 
PHE C    C N N 267 
PHE O    O N N 268 
PHE CB   C N N 269 
PHE CG   C Y N 270 
PHE CD1  C Y N 271 
PHE CD2  C Y N 272 
PHE CE1  C Y N 273 
PHE CE2  C Y N 274 
PHE CZ   C Y N 275 
PHE OXT  O N N 276 
PHE H    H N N 277 
PHE H2   H N N 278 
PHE HA   H N N 279 
PHE HB2  H N N 280 
PHE HB3  H N N 281 
PHE HD1  H N N 282 
PHE HD2  H N N 283 
PHE HE1  H N N 284 
PHE HE2  H N N 285 
PHE HZ   H N N 286 
PHE HXT  H N N 287 
PRO N    N N N 288 
PRO CA   C N S 289 
PRO C    C N N 290 
PRO O    O N N 291 
PRO CB   C N N 292 
PRO CG   C N N 293 
PRO CD   C N N 294 
PRO OXT  O N N 295 
PRO H    H N N 296 
PRO HA   H N N 297 
PRO HB2  H N N 298 
PRO HB3  H N N 299 
PRO HG2  H N N 300 
PRO HG3  H N N 301 
PRO HD2  H N N 302 
PRO HD3  H N N 303 
PRO HXT  H N N 304 
SER N    N N N 305 
SER CA   C N S 306 
SER C    C N N 307 
SER O    O N N 308 
SER CB   C N N 309 
SER OG   O N N 310 
SER OXT  O N N 311 
SER H    H N N 312 
SER H2   H N N 313 
SER HA   H N N 314 
SER HB2  H N N 315 
SER HB3  H N N 316 
SER HG   H N N 317 
SER HXT  H N N 318 
THR N    N N N 319 
THR CA   C N S 320 
THR C    C N N 321 
THR O    O N N 322 
THR CB   C N R 323 
THR OG1  O N N 324 
THR CG2  C N N 325 
THR OXT  O N N 326 
THR H    H N N 327 
THR H2   H N N 328 
THR HA   H N N 329 
THR HB   H N N 330 
THR HG1  H N N 331 
THR HG21 H N N 332 
THR HG22 H N N 333 
THR HG23 H N N 334 
THR HXT  H N N 335 
TYR N    N N N 336 
TYR CA   C N S 337 
TYR C    C N N 338 
TYR O    O N N 339 
TYR CB   C N N 340 
TYR CG   C Y N 341 
TYR CD1  C Y N 342 
TYR CD2  C Y N 343 
TYR CE1  C Y N 344 
TYR CE2  C Y N 345 
TYR CZ   C Y N 346 
TYR OH   O N N 347 
TYR OXT  O N N 348 
TYR H    H N N 349 
TYR H2   H N N 350 
TYR HA   H N N 351 
TYR HB2  H N N 352 
TYR HB3  H N N 353 
TYR HD1  H N N 354 
TYR HD2  H N N 355 
TYR HE1  H N N 356 
TYR HE2  H N N 357 
TYR HH   H N N 358 
TYR HXT  H N N 359 
VAL N    N N N 360 
VAL CA   C N S 361 
VAL C    C N N 362 
VAL O    O N N 363 
VAL CB   C N N 364 
VAL CG1  C N N 365 
VAL CG2  C N N 366 
VAL OXT  O N N 367 
VAL H    H N N 368 
VAL H2   H N N 369 
VAL HA   H N N 370 
VAL HB   H N N 371 
VAL HG11 H N N 372 
VAL HG12 H N N 373 
VAL HG13 H N N 374 
VAL HG21 H N N 375 
VAL HG22 H N N 376 
VAL HG23 H N N 377 
VAL HXT  H N N 378 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CSO N   CA   sing N N 70  
CSO N   H    sing N N 71  
CSO N   H2   sing N N 72  
CSO CA  CB   sing N N 73  
CSO CA  C    sing N N 74  
CSO CA  HA   sing N N 75  
CSO CB  SG   sing N N 76  
CSO CB  HB2  sing N N 77  
CSO CB  HB3  sing N N 78  
CSO SG  OD   sing N N 79  
CSO C   O    doub N N 80  
CSO C   OXT  sing N N 81  
CSO OXT HXT  sing N N 82  
CSO OD  HD   sing N N 83  
CYS N   CA   sing N N 84  
CYS N   H    sing N N 85  
CYS N   H2   sing N N 86  
CYS CA  C    sing N N 87  
CYS CA  CB   sing N N 88  
CYS CA  HA   sing N N 89  
CYS C   O    doub N N 90  
CYS C   OXT  sing N N 91  
CYS CB  SG   sing N N 92  
CYS CB  HB2  sing N N 93  
CYS CB  HB3  sing N N 94  
CYS SG  HG   sing N N 95  
CYS OXT HXT  sing N N 96  
GLN N   CA   sing N N 97  
GLN N   H    sing N N 98  
GLN N   H2   sing N N 99  
GLN CA  C    sing N N 100 
GLN CA  CB   sing N N 101 
GLN CA  HA   sing N N 102 
GLN C   O    doub N N 103 
GLN C   OXT  sing N N 104 
GLN CB  CG   sing N N 105 
GLN CB  HB2  sing N N 106 
GLN CB  HB3  sing N N 107 
GLN CG  CD   sing N N 108 
GLN CG  HG2  sing N N 109 
GLN CG  HG3  sing N N 110 
GLN CD  OE1  doub N N 111 
GLN CD  NE2  sing N N 112 
GLN NE2 HE21 sing N N 113 
GLN NE2 HE22 sing N N 114 
GLN OXT HXT  sing N N 115 
GLU N   CA   sing N N 116 
GLU N   H    sing N N 117 
GLU N   H2   sing N N 118 
GLU CA  C    sing N N 119 
GLU CA  CB   sing N N 120 
GLU CA  HA   sing N N 121 
GLU C   O    doub N N 122 
GLU C   OXT  sing N N 123 
GLU CB  CG   sing N N 124 
GLU CB  HB2  sing N N 125 
GLU CB  HB3  sing N N 126 
GLU CG  CD   sing N N 127 
GLU CG  HG2  sing N N 128 
GLU CG  HG3  sing N N 129 
GLU CD  OE1  doub N N 130 
GLU CD  OE2  sing N N 131 
GLU OE2 HE2  sing N N 132 
GLU OXT HXT  sing N N 133 
GLY N   CA   sing N N 134 
GLY N   H    sing N N 135 
GLY N   H2   sing N N 136 
GLY CA  C    sing N N 137 
GLY CA  HA2  sing N N 138 
GLY CA  HA3  sing N N 139 
GLY C   O    doub N N 140 
GLY C   OXT  sing N N 141 
GLY OXT HXT  sing N N 142 
HIS N   CA   sing N N 143 
HIS N   H    sing N N 144 
HIS N   H2   sing N N 145 
HIS CA  C    sing N N 146 
HIS CA  CB   sing N N 147 
HIS CA  HA   sing N N 148 
HIS C   O    doub N N 149 
HIS C   OXT  sing N N 150 
HIS CB  CG   sing N N 151 
HIS CB  HB2  sing N N 152 
HIS CB  HB3  sing N N 153 
HIS CG  ND1  sing Y N 154 
HIS CG  CD2  doub Y N 155 
HIS ND1 CE1  doub Y N 156 
HIS ND1 HD1  sing N N 157 
HIS CD2 NE2  sing Y N 158 
HIS CD2 HD2  sing N N 159 
HIS CE1 NE2  sing Y N 160 
HIS CE1 HE1  sing N N 161 
HIS NE2 HE2  sing N N 162 
HIS OXT HXT  sing N N 163 
HOH O   H1   sing N N 164 
HOH O   H2   sing N N 165 
ILE N   CA   sing N N 166 
ILE N   H    sing N N 167 
ILE N   H2   sing N N 168 
ILE CA  C    sing N N 169 
ILE CA  CB   sing N N 170 
ILE CA  HA   sing N N 171 
ILE C   O    doub N N 172 
ILE C   OXT  sing N N 173 
ILE CB  CG1  sing N N 174 
ILE CB  CG2  sing N N 175 
ILE CB  HB   sing N N 176 
ILE CG1 CD1  sing N N 177 
ILE CG1 HG12 sing N N 178 
ILE CG1 HG13 sing N N 179 
ILE CG2 HG21 sing N N 180 
ILE CG2 HG22 sing N N 181 
ILE CG2 HG23 sing N N 182 
ILE CD1 HD11 sing N N 183 
ILE CD1 HD12 sing N N 184 
ILE CD1 HD13 sing N N 185 
ILE OXT HXT  sing N N 186 
LEU N   CA   sing N N 187 
LEU N   H    sing N N 188 
LEU N   H2   sing N N 189 
LEU CA  C    sing N N 190 
LEU CA  CB   sing N N 191 
LEU CA  HA   sing N N 192 
LEU C   O    doub N N 193 
LEU C   OXT  sing N N 194 
LEU CB  CG   sing N N 195 
LEU CB  HB2  sing N N 196 
LEU CB  HB3  sing N N 197 
LEU CG  CD1  sing N N 198 
LEU CG  CD2  sing N N 199 
LEU CG  HG   sing N N 200 
LEU CD1 HD11 sing N N 201 
LEU CD1 HD12 sing N N 202 
LEU CD1 HD13 sing N N 203 
LEU CD2 HD21 sing N N 204 
LEU CD2 HD22 sing N N 205 
LEU CD2 HD23 sing N N 206 
LEU OXT HXT  sing N N 207 
LYS N   CA   sing N N 208 
LYS N   H    sing N N 209 
LYS N   H2   sing N N 210 
LYS CA  C    sing N N 211 
LYS CA  CB   sing N N 212 
LYS CA  HA   sing N N 213 
LYS C   O    doub N N 214 
LYS C   OXT  sing N N 215 
LYS CB  CG   sing N N 216 
LYS CB  HB2  sing N N 217 
LYS CB  HB3  sing N N 218 
LYS CG  CD   sing N N 219 
LYS CG  HG2  sing N N 220 
LYS CG  HG3  sing N N 221 
LYS CD  CE   sing N N 222 
LYS CD  HD2  sing N N 223 
LYS CD  HD3  sing N N 224 
LYS CE  NZ   sing N N 225 
LYS CE  HE2  sing N N 226 
LYS CE  HE3  sing N N 227 
LYS NZ  HZ1  sing N N 228 
LYS NZ  HZ2  sing N N 229 
LYS NZ  HZ3  sing N N 230 
LYS OXT HXT  sing N N 231 
MET N   CA   sing N N 232 
MET N   H    sing N N 233 
MET N   H2   sing N N 234 
MET CA  C    sing N N 235 
MET CA  CB   sing N N 236 
MET CA  HA   sing N N 237 
MET C   O    doub N N 238 
MET C   OXT  sing N N 239 
MET CB  CG   sing N N 240 
MET CB  HB2  sing N N 241 
MET CB  HB3  sing N N 242 
MET CG  SD   sing N N 243 
MET CG  HG2  sing N N 244 
MET CG  HG3  sing N N 245 
MET SD  CE   sing N N 246 
MET CE  HE1  sing N N 247 
MET CE  HE2  sing N N 248 
MET CE  HE3  sing N N 249 
MET OXT HXT  sing N N 250 
PHE N   CA   sing N N 251 
PHE N   H    sing N N 252 
PHE N   H2   sing N N 253 
PHE CA  C    sing N N 254 
PHE CA  CB   sing N N 255 
PHE CA  HA   sing N N 256 
PHE C   O    doub N N 257 
PHE C   OXT  sing N N 258 
PHE CB  CG   sing N N 259 
PHE CB  HB2  sing N N 260 
PHE CB  HB3  sing N N 261 
PHE CG  CD1  doub Y N 262 
PHE CG  CD2  sing Y N 263 
PHE CD1 CE1  sing Y N 264 
PHE CD1 HD1  sing N N 265 
PHE CD2 CE2  doub Y N 266 
PHE CD2 HD2  sing N N 267 
PHE CE1 CZ   doub Y N 268 
PHE CE1 HE1  sing N N 269 
PHE CE2 CZ   sing Y N 270 
PHE CE2 HE2  sing N N 271 
PHE CZ  HZ   sing N N 272 
PHE OXT HXT  sing N N 273 
PRO N   CA   sing N N 274 
PRO N   CD   sing N N 275 
PRO N   H    sing N N 276 
PRO CA  C    sing N N 277 
PRO CA  CB   sing N N 278 
PRO CA  HA   sing N N 279 
PRO C   O    doub N N 280 
PRO C   OXT  sing N N 281 
PRO CB  CG   sing N N 282 
PRO CB  HB2  sing N N 283 
PRO CB  HB3  sing N N 284 
PRO CG  CD   sing N N 285 
PRO CG  HG2  sing N N 286 
PRO CG  HG3  sing N N 287 
PRO CD  HD2  sing N N 288 
PRO CD  HD3  sing N N 289 
PRO OXT HXT  sing N N 290 
SER N   CA   sing N N 291 
SER N   H    sing N N 292 
SER N   H2   sing N N 293 
SER CA  C    sing N N 294 
SER CA  CB   sing N N 295 
SER CA  HA   sing N N 296 
SER C   O    doub N N 297 
SER C   OXT  sing N N 298 
SER CB  OG   sing N N 299 
SER CB  HB2  sing N N 300 
SER CB  HB3  sing N N 301 
SER OG  HG   sing N N 302 
SER OXT HXT  sing N N 303 
THR N   CA   sing N N 304 
THR N   H    sing N N 305 
THR N   H2   sing N N 306 
THR CA  C    sing N N 307 
THR CA  CB   sing N N 308 
THR CA  HA   sing N N 309 
THR C   O    doub N N 310 
THR C   OXT  sing N N 311 
THR CB  OG1  sing N N 312 
THR CB  CG2  sing N N 313 
THR CB  HB   sing N N 314 
THR OG1 HG1  sing N N 315 
THR CG2 HG21 sing N N 316 
THR CG2 HG22 sing N N 317 
THR CG2 HG23 sing N N 318 
THR OXT HXT  sing N N 319 
TYR N   CA   sing N N 320 
TYR N   H    sing N N 321 
TYR N   H2   sing N N 322 
TYR CA  C    sing N N 323 
TYR CA  CB   sing N N 324 
TYR CA  HA   sing N N 325 
TYR C   O    doub N N 326 
TYR C   OXT  sing N N 327 
TYR CB  CG   sing N N 328 
TYR CB  HB2  sing N N 329 
TYR CB  HB3  sing N N 330 
TYR CG  CD1  doub Y N 331 
TYR CG  CD2  sing Y N 332 
TYR CD1 CE1  sing Y N 333 
TYR CD1 HD1  sing N N 334 
TYR CD2 CE2  doub Y N 335 
TYR CD2 HD2  sing N N 336 
TYR CE1 CZ   doub Y N 337 
TYR CE1 HE1  sing N N 338 
TYR CE2 CZ   sing Y N 339 
TYR CE2 HE2  sing N N 340 
TYR CZ  OH   sing N N 341 
TYR OH  HH   sing N N 342 
TYR OXT HXT  sing N N 343 
VAL N   CA   sing N N 344 
VAL N   H    sing N N 345 
VAL N   H2   sing N N 346 
VAL CA  C    sing N N 347 
VAL CA  CB   sing N N 348 
VAL CA  HA   sing N N 349 
VAL C   O    doub N N 350 
VAL C   OXT  sing N N 351 
VAL CB  CG1  sing N N 352 
VAL CB  CG2  sing N N 353 
VAL CB  HB   sing N N 354 
VAL CG1 HG11 sing N N 355 
VAL CG1 HG12 sing N N 356 
VAL CG1 HG13 sing N N 357 
VAL CG2 HG21 sing N N 358 
VAL CG2 HG22 sing N N 359 
VAL CG2 HG23 sing N N 360 
VAL OXT HXT  sing N N 361 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           R35GM153337 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'Unpublished DJ-1 structure from X-ray source' 
# 
_pdbx_serial_crystallography_sample_delivery.diffrn_id     1 
_pdbx_serial_crystallography_sample_delivery.description   ? 
_pdbx_serial_crystallography_sample_delivery.method        'fixed target' 
# 
_pdbx_serial_crystallography_sample_delivery_fixed_target.diffrn_id                       1 
_pdbx_serial_crystallography_sample_delivery_fixed_target.description                     'Microcrystals raster scanned on a grid' 
_pdbx_serial_crystallography_sample_delivery_fixed_target.sample_holding                  ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.support_base                    ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.sample_unit_size                ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.crystals_per_unit               ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.sample_solvent                  ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.sample_dehydration_prevention   ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.motion_control                  ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.velocity_horizontal             ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.velocity_vertical               ? 
_pdbx_serial_crystallography_sample_delivery_fixed_target.details                         ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9CMX 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013102 
_atom_sites.fract_transf_matrix[1][2]   0.007564 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015128 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.013080 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ALA A 1 5   ? 31.59637 8.84989   -0.76535 1.000 83.58931  ? 2   ALA A N    1 
ATOM   2    C CA   . ALA A 1 5   ? 33.06674 8.60713   -0.73216 1.000 96.46361  ? 2   ALA A CA   1 
ATOM   3    C C    . ALA A 1 5   ? 33.50466 8.15960   0.67229  1.000 68.46954  ? 2   ALA A C    1 
ATOM   4    O O    . ALA A 1 5   ? 34.67936 7.87423   0.90255  1.000 64.08729  ? 2   ALA A O    1 
ATOM   5    C CB   . ALA A 1 5   ? 33.82490 9.86251   -1.16843 1.000 80.98381  ? 2   ALA A CB   1 
ATOM   6    H H    . ALA A 1 5   ? 31.35757 9.11349   -1.58119 1.000 100.26262 ? 2   ALA A H    1 
ATOM   7    H HA   . ALA A 1 5   ? 33.29206 7.90015   -1.35690 1.000 115.71179 ? 2   ALA A HA   1 
ATOM   8    H HB1  . ALA A 1 5   ? 34.77751 9.68179   -1.14058 1.000 97.13602  ? 2   ALA A HB1  1 
ATOM   9    H HB2  . ALA A 1 5   ? 33.55848 10.09436  -2.07184 1.000 97.13602  ? 2   ALA A HB2  1 
ATOM   10   H HB3  . ALA A 1 5   ? 33.60816 10.58871  -0.56298 1.000 97.13602  ? 2   ALA A HB3  1 
ATOM   11   N N    A SER A 1 6   ? 32.54534 8.09016   1.59336  0.461 57.79693  ? 3   SER A N    1 
ATOM   12   N N    B SER A 1 6   ? 32.56294 8.10654   1.61140  0.539 57.82434  ? 3   SER A N    1 
ATOM   13   C CA   A SER A 1 6   ? 32.82677 7.62644   2.94618  0.461 55.14311  ? 3   SER A CA   1 
ATOM   14   C CA   B SER A 1 6   ? 32.88459 7.66436   2.96431  0.539 55.14149  ? 3   SER A CA   1 
ATOM   15   C C    A SER A 1 6   ? 32.93321 6.10457   2.97398  0.461 36.85214  ? 3   SER A C    1 
ATOM   16   C C    B SER A 1 6   ? 32.91114 6.13707   3.02753  0.539 36.84798  ? 3   SER A C    1 
ATOM   17   O O    A SER A 1 6   ? 32.15295 5.40054   2.33130  0.461 44.29238  ? 3   SER A O    1 
ATOM   18   O O    B SER A 1 6   ? 32.06699 5.45939   2.44122  0.539 44.64684  ? 3   SER A O    1 
ATOM   19   C CB   A SER A 1 6   ? 31.73375 8.08785   3.91006  0.461 58.58675  ? 3   SER A CB   1 
ATOM   20   C CB   B SER A 1 6   ? 31.87792 8.23488   3.96689  0.539 60.00447  ? 3   SER A CB   1 
ATOM   21   O OG   A SER A 1 6   ? 32.01628 7.66180   5.23428  0.461 48.03926  ? 3   SER A OG   1 
ATOM   22   O OG   B SER A 1 6   ? 32.18983 9.59353   4.28576  0.539 46.04058  ? 3   SER A OG   1 
ATOM   23   H HA   A SER A 1 6   ? 33.67068 8.00000   3.24479  0.461 66.12718  ? 3   SER A HA   1 
ATOM   24   H HA   B SER A 1 6   ? 33.76307 7.98836   3.21768  0.539 66.12524  ? 3   SER A HA   1 
ATOM   25   H HB2  A SER A 1 6   ? 31.68611 9.05653   3.89328  0.461 70.25955  ? 3   SER A HB2  1 
ATOM   26   H HB2  B SER A 1 6   ? 30.98994 8.19782   3.57826  0.539 71.96081  ? 3   SER A HB2  1 
ATOM   27   H HB3  A SER A 1 6   ? 30.88562 7.70909   3.63055  0.461 70.25955  ? 3   SER A HB3  1 
ATOM   28   H HB3  B SER A 1 6   ? 31.90692 7.70546   4.77915  0.539 71.96081  ? 3   SER A HB3  1 
ATOM   29   H HG   A SER A 1 6   ? 31.50083 8.04512   5.77555  0.461 57.60256  ? 3   SER A HG   1 
ATOM   30   H HG   B SER A 1 6   ? 31.52763 9.96317   4.64695  0.539 55.20415  ? 3   SER A HG   1 
ATOM   31   N N    . LYS A 1 7   ? 33.90994 5.59525   3.71686  1.000 30.92049  ? 4   LYS A N    1 
ATOM   32   C CA   . LYS A 1 7   ? 33.99019 4.13619   3.90282  1.000 27.82580  ? 4   LYS A CA   1 
ATOM   33   C C    . LYS A 1 7   ? 32.93750 3.68761   4.91038  1.000 29.52835  ? 4   LYS A C    1 
ATOM   34   O O    . LYS A 1 7   ? 32.45239 4.48276   5.73046  1.000 28.94422  ? 4   LYS A O    1 
ATOM   35   C CB   . LYS A 1 7   ? 35.38985 3.75180   4.35986  1.000 29.89112  ? 4   LYS A CB   1 
ATOM   36   C CG   . LYS A 1 7   ? 36.48418 4.29694   3.49441  1.000 37.10870  ? 4   LYS A CG   1 
ATOM   37   C CD   . LYS A 1 7   ? 36.65953 3.47887   2.24741  1.000 44.60170  ? 4   LYS A CD   1 
ATOM   38   C CE   . LYS A 1 7   ? 37.88564 3.96795   1.51409  1.000 60.62057  ? 4   LYS A CE   1 
ATOM   39   N NZ   . LYS A 1 7   ? 38.39520 2.95667   0.56546  1.000 69.49407  ? 4   LYS A NZ   1 
ATOM   40   H HA   . LYS A 1 7   ? 33.81765 3.67111   3.06926  1.000 33.34641  ? 4   LYS A HA   1 
ATOM   41   H HB2  . LYS A 1 7   ? 35.52756 4.09060   5.25827  1.000 35.82479  ? 4   LYS A HB2  1 
ATOM   42   H HB3  . LYS A 1 7   ? 35.46383 2.78463   4.35506  1.000 35.82479  ? 4   LYS A HB3  1 
ATOM   43   H HG2  . LYS A 1 7   ? 36.26574 5.20561   3.23459  1.000 44.48589  ? 4   LYS A HG2  1 
ATOM   44   H HG3  . LYS A 1 7   ? 37.31967 4.28451   3.98705  1.000 44.48589  ? 4   LYS A HG3  1 
ATOM   45   H HD2  . LYS A 1 7   ? 36.78062 2.54450   2.47802  1.000 53.47749  ? 4   LYS A HD2  1 
ATOM   46   H HD3  . LYS A 1 7   ? 35.88522 3.58096   1.67216  1.000 53.47749  ? 4   LYS A HD3  1 
ATOM   47   H HE2  . LYS A 1 7   ? 37.66170 4.76838   1.01403  1.000 72.70013  ? 4   LYS A HE2  1 
ATOM   48   H HE3  . LYS A 1 7   ? 38.58621 4.16296   2.15603  1.000 72.70013  ? 4   LYS A HE3  1 
ATOM   49   H HZ1  . LYS A 1 7   ? 39.11985 3.26564   0.15131  1.000 83.34833  ? 4   LYS A HZ1  1 
ATOM   50   H HZ2  . LYS A 1 7   ? 38.60772 2.21033   1.00123  1.000 83.34833  ? 4   LYS A HZ2  1 
ATOM   51   H HZ3  . LYS A 1 7   ? 37.77301 2.76890   -0.04259 1.000 83.34833  ? 4   LYS A HZ3  1 
ATOM   52   N N    A ARG A 1 8   ? 32.54605 2.41989   4.82064  0.481 27.18265  ? 5   ARG A N    1 
ATOM   53   N N    B ARG A 1 8   ? 32.61482 2.38577   4.87391  0.519 26.89850  ? 5   ARG A N    1 
ATOM   54   C CA   A ARG A 1 8   ? 31.51954 1.86630   5.69020  0.481 27.00155  ? 5   ARG A CA   1 
ATOM   55   C CA   B ARG A 1 8   ? 31.51856 1.83813   5.66996  0.519 27.05150  ? 5   ARG A CA   1 
ATOM   56   C C    A ARG A 1 8   ? 32.09867 0.65284   6.40416  0.481 25.92249  ? 5   ARG A C    1 
ATOM   57   C C    B ARG A 1 8   ? 31.90737 0.52486   6.34430  0.519 22.83235  ? 5   ARG A C    1 
ATOM   58   O O    A ARG A 1 8   ? 32.95159 -0.04760  5.85139  0.481 22.57445  ? 5   ARG A O    1 
ATOM   59   O O    B ARG A 1 8   ? 32.35589 -0.41649  5.68830  0.519 23.46434  ? 5   ARG A O    1 
ATOM   60   C CB   A ARG A 1 8   ? 30.25967 1.46543   4.90846  0.481 31.19823  ? 5   ARG A CB   1 
ATOM   61   C CB   B ARG A 1 8   ? 30.27066 1.59037   4.81876  0.519 32.48497  ? 5   ARG A CB   1 
ATOM   62   C CG   A ARG A 1 8   ? 29.67274 2.61121   4.09035  0.481 40.44613  ? 5   ARG A CG   1 
ATOM   63   C CG   B ARG A 1 8   ? 29.76767 2.81412   4.07219  0.519 37.88252  ? 5   ARG A CG   1 
ATOM   64   C CD   A ARG A 1 8   ? 28.43755 2.18326   3.30725  0.481 50.97424  ? 5   ARG A CD   1 
ATOM   65   C CD   B ARG A 1 8   ? 28.65986 2.46430   3.07934  0.519 50.92857  ? 5   ARG A CD   1 
ATOM   66   N NE   A ARG A 1 8   ? 27.20905 2.43897   4.05381  0.481 61.97154  ? 5   ARG A NE   1 
ATOM   67   N NE   B ARG A 1 8   ? 27.40461 2.16718   3.76078  0.519 59.02333  ? 5   ARG A NE   1 
ATOM   68   C CZ   A ARG A 1 8   ? 26.46450 3.52952   3.91651  0.481 65.90405  ? 5   ARG A CZ   1 
ATOM   69   C CZ   B ARG A 1 8   ? 26.71991 1.03949   3.62854  0.519 54.25911  ? 5   ARG A CZ   1 
ATOM   70   N NH1  A ARG A 1 8   ? 26.77458 4.47610   3.04276  0.481 68.30126  ? 5   ARG A NH1  1 
ATOM   71   N NH1  B ARG A 1 8   ? 27.11220 0.08284   2.80141  0.519 53.14400  ? 5   ARG A NH1  1 
ATOM   72   N NH2  A ARG A 1 8   ? 25.38330 3.67547   4.67450  0.481 65.58247  ? 5   ARG A NH2  1 
ATOM   73   N NH2  B ARG A 1 8   ? 25.60456 0.87355   4.33366  0.519 52.85066  ? 5   ARG A NH2  1 
ATOM   74   H HA   A ARG A 1 8   ? 31.25079 2.52808   6.34650  0.481 32.35730  ? 5   ARG A HA   1 
ATOM   75   H HA   B ARG A 1 8   ? 31.32831 2.48635   6.36603  0.519 32.41725  ? 5   ARG A HA   1 
ATOM   76   H HB2  A ARG A 1 8   ? 30.48446 0.74641   4.29741  0.481 37.39333  ? 5   ARG A HB2  1 
ATOM   77   H HB2  B ARG A 1 8   ? 30.47585 0.90853   4.16006  0.519 38.93742  ? 5   ARG A HB2  1 
ATOM   78   H HB3  A ARG A 1 8   ? 29.58198 1.16818   5.53558  0.481 37.39333  ? 5   ARG A HB3  1 
ATOM   79   H HB3  B ARG A 1 8   ? 29.55555 1.28628   5.39931  0.519 38.93742  ? 5   ARG A HB3  1 
ATOM   80   H HG2  A ARG A 1 8   ? 29.41730 3.33148   4.68774  0.481 48.49081  ? 5   ARG A HG2  1 
ATOM   81   H HG2  B ARG A 1 8   ? 29.41223 3.45322   4.70946  0.519 45.41448  ? 5   ARG A HG2  1 
ATOM   82   H HG3  A ARG A 1 8   ? 30.33790 2.92491   3.45786  0.481 48.49081  ? 5   ARG A HG3  1 
ATOM   83   H HG3  B ARG A 1 8   ? 30.50216 3.21129   3.57856  0.519 45.41448  ? 5   ARG A HG3  1 
ATOM   84   H HD2  A ARG A 1 8   ? 28.39726 2.68094   2.47563  0.481 61.12454  ? 5   ARG A HD2  1 
ATOM   85   H HD2  B ARG A 1 8   ? 28.51320 3.21598   2.48405  0.519 61.06973  ? 5   ARG A HD2  1 
ATOM   86   H HD3  A ARG A 1 8   ? 28.48894 1.23237   3.12266  0.481 61.12454  ? 5   ARG A HD3  1 
ATOM   87   H HD3  B ARG A 1 8   ? 28.92190 1.68259   2.56830  0.519 61.06973  ? 5   ARG A HD3  1 
ATOM   88   H HE   A ARG A 1 8   ? 26.95102 1.84453   4.61920  0.481 74.32130  ? 5   ARG A HE   1 
ATOM   89   H HE   B ARG A 1 8   ? 27.08523 2.76772   4.28703  0.519 70.78345  ? 5   ARG A HE   1 
ATOM   90   H HH11 A ARG A 1 8   ? 27.47273 4.39227   2.54762  0.481 81.91696  ? 5   ARG A HH11 1 
ATOM   91   H HH11 B ARG A 1 8   ? 27.82678 0.18490   2.33392  0.519 63.72825  ? 5   ARG A HH11 1 
ATOM   92   H HH12 A ARG A 1 8   ? 26.27769 5.17433   2.97078  0.481 81.91696  ? 5   ARG A HH12 1 
ATOM   93   H HH12 B ARG A 1 8   ? 26.65240 -0.64057  2.73168  0.519 63.72825  ? 5   ARG A HH12 1 
ATOM   94   H HH21 A ARG A 1 8   ? 25.17318 3.06764   5.24545  0.481 78.65442  ? 5   ARG A HH21 1 
ATOM   95   H HH21 B ARG A 1 8   ? 25.33647 1.49313   4.86643  0.519 63.37624  ? 5   ARG A HH21 1 
ATOM   96   H HH22 A ARG A 1 8   ? 24.89349 4.37779   4.59423  0.481 78.65442  ? 5   ARG A HH22 1 
ATOM   97   H HH22 B ARG A 1 8   ? 25.15141 0.14667   4.25685  0.519 63.37624  ? 5   ARG A HH22 1 
ATOM   98   N N    . ALA A 1 9   ? 31.66620 0.44082   7.64565  1.000 23.22343  ? 6   ALA A N    1 
ATOM   99   C CA   . ALA A 1 9   ? 32.03972 -0.72875  8.42788  1.000 24.61635  ? 6   ALA A CA   1 
ATOM   100  C C    . ALA A 1 9   ? 30.81807 -1.35891  9.05538  1.000 24.18605  ? 6   ALA A C    1 
ATOM   101  O O    . ALA A 1 9   ? 29.91998 -0.66713  9.53418  1.000 25.95594  ? 6   ALA A O    1 
ATOM   102  C CB   . ALA A 1 9   ? 33.04222 -0.33052  9.55417  1.000 24.81935  ? 6   ALA A CB   1 
ATOM   103  H HA   . ALA A 1 9   ? 32.44790 -1.38630  7.84314  1.000 29.49507  ? 6   ALA A HA   1 
ATOM   104  H HB1  . ALA A 1 9   ? 33.29313 -1.12596  10.04936 1.000 29.73867  ? 6   ALA A HB1  1 
ATOM   105  H HB2  . ALA A 1 9   ? 33.82828 0.06942   9.15038  1.000 29.73867  ? 6   ALA A HB2  1 
ATOM   106  H HB3  . ALA A 1 9   ? 32.61425 0.30690   10.14700 1.000 29.73867  ? 6   ALA A HB3  1 
ATOM   107  N N    . LEU A 1 10  ? 30.77871 -2.68603  9.04351  1.000 21.45700  ? 7   LEU A N    1 
ATOM   108  C CA   . LEU A 1 10  ? 29.75652 -3.45021  9.73442  1.000 20.53351  ? 7   LEU A CA   1 
ATOM   109  C C    . LEU A 1 10  ? 30.38907 -4.15166  10.92662 1.000 23.93184  ? 7   LEU A C    1 
ATOM   110  O O    . LEU A 1 10  ? 31.31420 -4.93210  10.72936 1.000 23.18440  ? 7   LEU A O    1 
ATOM   111  C CB   . LEU A 1 10  ? 29.15540 -4.51251  8.82145  1.000 22.13223  ? 7   LEU A CB   1 
ATOM   112  C CG   . LEU A 1 10  ? 28.04446 -5.39255  9.39633  1.000 24.10870  ? 7   LEU A CG   1 
ATOM   113  C CD1  . LEU A 1 10  ? 26.83858 -4.56343  9.70007  1.000 28.98311  ? 7   LEU A CD1  1 
ATOM   114  C CD2  . LEU A 1 10  ? 27.78701 -6.49628  8.36957  1.000 27.86484  ? 7   LEU A CD2  1 
ATOM   115  H H    . LEU A 1 10  ? 31.35100 -3.17658  8.62946  1.000 25.70386  ? 7   LEU A H    1 
ATOM   116  H HA   . LEU A 1 10  ? 29.06372 -2.84083  10.03369 1.000 24.59566  ? 7   LEU A HA   1 
ATOM   117  H HB2  . LEU A 1 10  ? 28.78387 -4.06187  8.04699  1.000 26.51413  ? 7   LEU A HB2  1 
ATOM   118  H HB3  . LEU A 1 10  ? 29.87104 -5.10728  8.54758  1.000 26.51413  ? 7   LEU A HB3  1 
ATOM   119  H HG   . LEU A 1 10  ? 28.28485 -5.80511  10.24067 1.000 28.88589  ? 7   LEU A HG   1 
ATOM   120  H HD11 . LEU A 1 10  ? 26.14805 -5.13453  10.07144 1.000 34.73518  ? 7   LEU A HD11 1 
ATOM   121  H HD12 . LEU A 1 10  ? 27.08058 -3.87715  10.34143 1.000 34.73518  ? 7   LEU A HD12 1 
ATOM   122  H HD13 . LEU A 1 10  ? 26.52273 -4.15307  8.87986  1.000 34.73518  ? 7   LEU A HD13 1 
ATOM   123  H HD21 . LEU A 1 10  ? 27.09799 -7.08876  8.70886  1.000 33.39326  ? 7   LEU A HD21 1 
ATOM   124  H HD22 . LEU A 1 10  ? 27.49521 -6.09183  7.53760  1.000 33.39326  ? 7   LEU A HD22 1 
ATOM   125  H HD23 . LEU A 1 10  ? 28.60834 -6.99202  8.22616  1.000 33.39326  ? 7   LEU A HD23 1 
ATOM   126  N N    . VAL A 1 11  ? 29.85221 -3.93361  12.12908 1.000 21.42615  ? 8   VAL A N    1 
ATOM   127  C CA   . VAL A 1 11  ? 30.29724 -4.61201  13.34224 1.000 19.46101  ? 8   VAL A CA   1 
ATOM   128  C C    . VAL A 1 11  ? 29.15707 -5.50332  13.80140 1.000 27.14797  ? 8   VAL A C    1 
ATOM   129  O O    . VAL A 1 11  ? 28.05711 -5.00667  14.04495 1.000 26.31257  ? 8   VAL A O    1 
ATOM   130  C CB   . VAL A 1 11  ? 30.67472 -3.59892  14.44904 1.000 19.02386  ? 8   VAL A CB   1 
ATOM   131  C CG1  . VAL A 1 11  ? 31.07923 -4.38005  15.72474 1.000 22.43376  ? 8   VAL A CG1  1 
ATOM   132  C CG2  . VAL A 1 11  ? 31.79872 -2.73639  13.99533 1.000 21.48841  ? 8   VAL A CG2  1 
ATOM   133  H H    . VAL A 1 11  ? 29.20933 -3.37960  12.26831 1.000 25.66682  ? 8   VAL A H    1 
ATOM   134  H HA   . VAL A 1 11  ? 31.07279 -5.16085  13.14678 1.000 23.30866  ? 8   VAL A HA   1 
ATOM   135  H HB   . VAL A 1 11  ? 29.91765 -3.02586  14.64737 1.000 22.78408  ? 8   VAL A HB   1 
ATOM   136  H HG11 . VAL A 1 11  ? 31.33330 -3.74768  16.41499 1.000 26.87596  ? 8   VAL A HG11 1 
ATOM   137  H HG12 . VAL A 1 11  ? 30.32366 -4.90993  16.02347 1.000 26.87596  ? 8   VAL A HG12 1 
ATOM   138  H HG13 . VAL A 1 11  ? 31.82804 -4.96013  15.51572 1.000 26.87596  ? 8   VAL A HG13 1 
ATOM   139  H HG21 . VAL A 1 11  ? 32.00611 -2.09504  14.69287 1.000 25.74154  ? 8   VAL A HG21 1 
ATOM   140  H HG22 . VAL A 1 11  ? 32.57256 -3.29360  13.81760 1.000 25.74154  ? 8   VAL A HG22 1 
ATOM   141  H HG23 . VAL A 1 11  ? 31.53329 -2.27123  13.18658 1.000 25.74154  ? 8   VAL A HG23 1 
ATOM   142  N N    . ILE A 1 12  ? 29.39028 -6.81679  13.91492 1.000 20.22121  ? 9   ILE A N    1 
ATOM   143  C CA   . ILE A 1 12  ? 28.32363 -7.76208  14.22412 1.000 21.47350  ? 9   ILE A CA   1 
ATOM   144  C C    . ILE A 1 12  ? 28.35099 -8.08626  15.71002 1.000 23.67413  ? 9   ILE A C    1 
ATOM   145  O O    . ILE A 1 12  ? 29.37199 -8.55850  16.23148 1.000 25.02048  ? 9   ILE A O    1 
ATOM   146  C CB   . ILE A 1 12  ? 28.42211 -9.04745  13.38244 1.000 21.44370  ? 9   ILE A CB   1 
ATOM   147  C CG1  . ILE A 1 12  ? 28.51449 -8.66427  11.88884 1.000 27.32864  ? 9   ILE A CG1  1 
ATOM   148  C CG2  . ILE A 1 12  ? 27.20626 -9.92879  13.66275 1.000 24.88640  ? 9   ILE A CG2  1 
ATOM   149  C CD1  . ILE A 1 12  ? 28.58617 -9.84390  10.94412 1.000 32.12757  ? 9   ILE A CD1  1 
ATOM   150  H H    . ILE A 1 12  ? 30.16341 -7.18016  13.81573 1.000 24.22090  ? 9   ILE A H    1 
ATOM   151  H HA   . ILE A 1 12  ? 27.47821 -7.32953  14.02649 1.000 25.72365  ? 9   ILE A HA   1 
ATOM   152  H HB   . ILE A 1 12  ? 29.21862 -9.54798  13.61896 1.000 25.68788  ? 9   ILE A HB   1 
ATOM   153  H HG12 . ILE A 1 12  ? 27.72857 -8.14697  11.65298 1.000 32.74982  ? 9   ILE A HG12 1 
ATOM   154  H HG13 . ILE A 1 12  ? 29.31438 -8.13219  11.75485 1.000 32.74982  ? 9   ILE A HG13 1 
ATOM   155  H HG21 . ILE A 1 12  ? 27.28095 -10.74447 13.14315 1.000 29.81913  ? 9   ILE A HG21 1 
ATOM   156  H HG22 . ILE A 1 12  ? 27.18112 -10.14052 14.60902 1.000 29.81913  ? 9   ILE A HG22 1 
ATOM   157  H HG23 . ILE A 1 12  ? 26.40265 -9.44796  13.40992 1.000 29.81913  ? 9   ILE A HG23 1 
ATOM   158  H HD11 . ILE A 1 12  ? 28.62745 -9.51607  10.03213 1.000 38.50853  ? 9   ILE A HD11 1 
ATOM   159  H HD12 . ILE A 1 12  ? 29.38103 -10.36205 11.14566 1.000 38.50853  ? 9   ILE A HD12 1 
ATOM   160  H HD13 . ILE A 1 12  ? 27.79492 -10.39225 11.06301 1.000 38.50853  ? 9   ILE A HD13 1 
ATOM   161  N N    . LEU A 1 13  ? 27.24532 -7.80853  16.41378 1.000 22.04888  ? 10  LEU A N    1 
ATOM   162  C CA   . LEU A 1 13  ? 27.21323 -7.81601  17.87686 1.000 20.08025  ? 10  LEU A CA   1 
ATOM   163  C C    . LEU A 1 13  ? 26.26170 -8.90784  18.36535 1.000 21.56004  ? 10  LEU A C    1 
ATOM   164  O O    . LEU A 1 13  ? 25.04511 -8.87185  18.12577 1.000 25.48728  ? 10  LEU A O    1 
ATOM   165  C CB   . LEU A 1 13  ? 26.79283 -6.44863  18.41448 1.000 24.62149  ? 10  LEU A CB   1 
ATOM   166  C CG   . LEU A 1 13  ? 26.60080 -6.31667  19.92466 1.000 26.77945  ? 10  LEU A CG   1 
ATOM   167  C CD1  . LEU A 1 13  ? 27.91228 -6.65914  20.63289 1.000 27.82506  ? 10  LEU A CD1  1 
ATOM   168  C CD2  . LEU A 1 13  ? 26.16056 -4.93746  20.29568 1.000 32.50310  ? 10  LEU A CD2  1 
ATOM   169  H H    . LEU A 1 13  ? 26.48912 -7.60954  16.05577 1.000 26.41411  ? 10  LEU A H    1 
ATOM   170  H HA   . LEU A 1 13  ? 28.09998 -8.03110  18.20597 1.000 24.05175  ? 10  LEU A HA   1 
ATOM   171  H HB2  . LEU A 1 13  ? 27.47465 -5.80715  18.16047 1.000 29.50124  ? 10  LEU A HB2  1 
ATOM   172  H HB3  . LEU A 1 13  ? 25.94681 -6.21449  18.00178 1.000 29.50124  ? 10  LEU A HB3  1 
ATOM   173  H HG   . LEU A 1 13  ? 25.90776 -6.93107  20.21297 1.000 32.09079  ? 10  LEU A HG   1 
ATOM   174  H HD11 . LEU A 1 13  ? 27.78392 -6.57946  21.59105 1.000 33.34553  ? 10  LEU A HD11 1 
ATOM   175  H HD12 . LEU A 1 13  ? 28.16492 -7.56812  20.40745 1.000 33.34553  ? 10  LEU A HD12 1 
ATOM   176  H HD13 . LEU A 1 13  ? 28.60046 -6.04198  20.33890 1.000 33.34553  ? 10  LEU A HD13 1 
ATOM   177  H HD21 . LEU A 1 13  ? 26.04833 -4.88994  21.25800 1.000 38.95917  ? 10  LEU A HD21 1 
ATOM   178  H HD22 . LEU A 1 13  ? 26.83600 -4.30272  20.00970 1.000 38.95917  ? 10  LEU A HD22 1 
ATOM   179  H HD23 . LEU A 1 13  ? 25.31829 -4.74542  19.85455 1.000 38.95917  ? 10  LEU A HD23 1 
ATOM   180  N N    . ALA A 1 14  ? 26.82388 -9.89921  19.02021 1.000 22.30653  ? 11  ALA A N    1 
ATOM   181  C CA   . ALA A 1 14  ? 26.08847 -11.06093 19.52322 1.000 22.54477  ? 11  ALA A CA   1 
ATOM   182  C C    . ALA A 1 14  ? 26.15208 -11.10262 21.03563 1.000 28.13360  ? 11  ALA A C    1 
ATOM   183  O O    . ALA A 1 14  ? 27.10230 -10.59282 21.63916 1.000 23.31115  ? 11  ALA A O    1 
ATOM   184  C CB   . ALA A 1 14  ? 26.67855 -12.35163 18.95465 1.000 25.91514  ? 11  ALA A CB   1 
ATOM   185  H H    . ALA A 1 14  ? 27.66462 -9.93258  19.19809 1.000 26.72329  ? 11  ALA A H    1 
ATOM   186  H HA   . ALA A 1 14  ? 25.15655 -10.99414 19.26254 1.000 27.00918  ? 11  ALA A HA   1 
ATOM   187  H HB1  . ALA A 1 14  ? 26.15730 -13.10472 19.27409 1.000 31.05362  ? 11  ALA A HB1  1 
ATOM   188  H HB2  . ALA A 1 14  ? 26.64591 -12.31389 17.98593 1.000 31.05362  ? 11  ALA A HB2  1 
ATOM   189  H HB3  . ALA A 1 14  ? 27.59811 -12.43610 19.25159 1.000 31.05362  ? 11  ALA A HB3  1 
ATOM   190  N N    . LYS A 1 15  ? 25.15288 -11.74858 21.63712 1.000 22.66275  ? 12  LYS A N    1 
ATOM   191  C CA   . LYS A 1 15  ? 25.17597 -11.95668 23.07597 1.000 22.62140  ? 12  LYS A CA   1 
ATOM   192  C C    . LYS A 1 15  ? 26.47179 -12.65469 23.49462 1.000 22.26500  ? 12  LYS A C    1 
ATOM   193  O O    . LYS A 1 15  ? 26.93996 -13.60104 22.84854 1.000 25.74265  ? 12  LYS A O    1 
ATOM   194  C CB   . LYS A 1 15  ? 23.96737 -12.80402 23.50739 1.000 26.13741  ? 12  LYS A CB   1 
ATOM   195  C CG   . LYS A 1 15  ? 23.91376 -13.00194 25.02946 1.000 30.52434  ? 12  LYS A CG   1 
ATOM   196  C CD   . LYS A 1 15  ? 22.69592 -13.78063 25.53959 1.000 50.26789  ? 12  LYS A CD   1 
ATOM   197  C CE   . LYS A 1 15  ? 22.53800 -13.57740 27.05490 1.000 58.98035  ? 12  LYS A CE   1 
ATOM   198  N NZ   . LYS A 1 15  ? 23.77459 -13.87849 27.83527 1.000 75.94043  ? 12  LYS A NZ   1 
ATOM   199  H H    . LYS A 1 15  ? 24.46256 -12.06969 21.23720 1.000 27.15076  ? 12  LYS A H    1 
ATOM   200  H HA   . LYS A 1 15  ? 25.12359 -11.09710 23.52239 1.000 27.10113  ? 12  LYS A HA   1 
ATOM   201  H HB2  . LYS A 1 15  ? 23.15141 -12.35839 23.23076 1.000 31.32034  ? 12  LYS A HB2  1 
ATOM   202  H HB3  . LYS A 1 15  ? 24.02611 -13.67767 23.09002 1.000 31.32034  ? 12  LYS A HB3  1 
ATOM   203  H HG2  . LYS A 1 15  ? 24.70572 -13.48989 25.30444 1.000 36.58466  ? 12  LYS A HG2  1 
ATOM   204  H HG3  . LYS A 1 15  ? 23.89799 -12.12939 25.45290 1.000 36.58466  ? 12  LYS A HG3  1 
ATOM   205  H HD2  . LYS A 1 15  ? 21.89426 -13.45992 25.09756 1.000 60.27691  ? 12  LYS A HD2  1 
ATOM   206  H HD3  . LYS A 1 15  ? 22.81582 -14.72696 25.36354 1.000 60.27691  ? 12  LYS A HD3  1 
ATOM   207  H HE2  . LYS A 1 15  ? 22.30089 -12.65194 27.22283 1.000 70.73187  ? 12  LYS A HE2  1 
ATOM   208  H HE3  . LYS A 1 15  ? 21.83550 -14.16357 27.37707 1.000 70.73187  ? 12  LYS A HE3  1 
ATOM   209  H HZ1  . LYS A 1 15  ? 23.62564 -13.74992 28.70325 1.000 91.08397  ? 12  LYS A HZ1  1 
ATOM   210  H HZ2  . LYS A 1 15  ? 24.01746 -14.72492 27.70617 1.000 91.08397  ? 12  LYS A HZ2  1 
ATOM   211  H HZ3  . LYS A 1 15  ? 24.43707 -13.34481 27.57374 1.000 91.08397  ? 12  LYS A HZ3  1 
ATOM   212  N N    . GLY A 1 16  ? 27.10027 -12.13773 24.54214 1.000 22.14632  ? 13  GLY A N    1 
ATOM   213  C CA   . GLY A 1 16  ? 28.34888 -12.72082 24.99093 1.000 23.15171  ? 13  GLY A CA   1 
ATOM   214  C C    . GLY A 1 16  ? 29.57619 -12.12626 24.38111 1.000 20.93842  ? 13  GLY A C    1 
ATOM   215  O O    . GLY A 1 16  ? 30.69019 -12.59357 24.68402 1.000 22.60284  ? 13  GLY A O    1 
ATOM   216  H H    . GLY A 1 16  ? 26.82625 -11.46235 24.99862 1.000 26.53103  ? 13  GLY A H    1 
ATOM   217  H HA2  . GLY A 1 16  ? 28.41420 -12.61208 25.95260 1.000 27.73751  ? 13  GLY A HA2  1 
ATOM   218  H HA3  . GLY A 1 16  ? 28.34282 -13.66756 24.77986 1.000 27.73751  ? 13  GLY A HA3  1 
ATOM   219  N N    . ALA A 1 17  ? 29.42921 -11.13222 23.51233 1.000 18.44391  ? 14  ALA A N    1 
ATOM   220  C CA   . ALA A 1 17  ? 30.59959 -10.48854 22.94597 1.000 20.81087  ? 14  ALA A CA   1 
ATOM   221  C C    . ALA A 1 17  ? 31.40489 -9.75937  24.02396 1.000 21.14860  ? 14  ALA A C    1 
ATOM   222  O O    . ALA A 1 17  ? 30.87605 -9.31364  25.04184 1.000 20.81081  ? 14  ALA A O    1 
ATOM   223  C CB   . ALA A 1 17  ? 30.19711 -9.53778  21.86351 1.000 21.59499  ? 14  ALA A CB   1 
ATOM   224  H H    . ALA A 1 17  ? 28.67538 -10.81949 23.24115 1.000 22.08814  ? 14  ALA A H    1 
ATOM   225  H HA   . ALA A 1 17  ? 31.17614 -11.16395 22.55570 1.000 24.92850  ? 14  ALA A HA   1 
ATOM   226  H HB1  . ALA A 1 17  ? 30.99395 -9.13417  21.48531 1.000 25.86944  ? 14  ALA A HB1  1 
ATOM   227  H HB2  . ALA A 1 17  ? 29.71598 -10.02599 21.17717 1.000 25.86944  ? 14  ALA A HB2  1 
ATOM   228  H HB3  . ALA A 1 17  ? 29.62647 -8.85101  22.24249 1.000 25.86944  ? 14  ALA A HB3  1 
ATOM   229  N N    . GLU A 1 18  ? 32.69864 -9.59523  23.76058 1.000 17.90711  ? 15  GLU A N    1 
ATOM   230  C CA   . GLU A 1 18  ? 33.55134 -8.83356  24.66360 1.000 17.42949  ? 15  GLU A CA   1 
ATOM   231  C C    . GLU A 1 18  ? 33.32371 -7.35545  24.41709 1.000 17.55641  ? 15  GLU A C    1 
ATOM   232  O O    . GLU A 1 18  ? 33.60478 -6.86036  23.32403 1.000 20.11863  ? 15  GLU A O    1 
ATOM   233  C CB   . GLU A 1 18  ? 35.01682 -9.18695  24.48676 1.000 17.81071  ? 15  GLU A CB   1 
ATOM   234  C CG   . GLU A 1 18  ? 35.76678 -9.36007  25.82799 1.000 20.98385  ? 15  GLU A CG   1 
ATOM   235  C CD   . GLU A 1 18  ? 35.84269 -8.05832  26.64006 1.000 23.11875  ? 15  GLU A CD   1 
ATOM   236  O OE1  . GLU A 1 18  ? 35.84981 -6.96253  26.02746 1.000 20.44194  ? 15  GLU A OE1  1 
ATOM   237  O OE2  . GLU A 1 18  ? 35.84936 -8.16720  27.86760 1.000 21.23403  ? 15  GLU A OE2  1 
ATOM   238  H H    . GLU A 1 18  ? 33.10177 -9.91308  23.07061 1.000 21.44398  ? 15  GLU A H    1 
ATOM   239  H HA   . GLU A 1 18  ? 33.31503 -9.05044  25.57903 1.000 20.87083  ? 15  GLU A HA   1 
ATOM   240  H HB2  . GLU A 1 18  ? 35.08172 -10.02244 23.99825 1.000 21.32831  ? 15  GLU A HB2  1 
ATOM   241  H HB3  . GLU A 1 18  ? 35.45330 -8.47736  23.98991 1.000 21.32831  ? 15  GLU A HB3  1 
ATOM   242  H HG2  . GLU A 1 18  ? 35.30429 -10.02204 26.36539 1.000 25.13607  ? 15  GLU A HG2  1 
ATOM   243  H HG3  . GLU A 1 18  ? 36.67337 -9.65396  25.64736 1.000 25.13607  ? 15  GLU A HG3  1 
ATOM   244  N N    . GLU A 1 19  ? 32.79012 -6.64897  25.41242 1.000 19.64423  ? 16  GLU A N    1 
ATOM   245  C CA   . GLU A 1 19  ? 32.34917 -5.26406  25.16023 1.000 20.41903  ? 16  GLU A CA   1 
ATOM   246  C C    . GLU A 1 19  ? 33.50411 -4.29226  24.90732 1.000 19.57004  ? 16  GLU A C    1 
ATOM   247  O O    . GLU A 1 19  ? 33.31359 -3.30754  24.18091 1.000 19.15207  ? 16  GLU A O    1 
ATOM   248  C CB   . GLU A 1 19  ? 31.48536 -4.74904  26.31227 1.000 17.51382  ? 16  GLU A CB   1 
ATOM   249  C CG   . GLU A 1 19  ? 32.00174 -5.08453  27.69284 1.000 21.84005  ? 16  GLU A CG   1 
ATOM   250  C CD   . GLU A 1 19  ? 31.43985 -6.40436  28.22409 1.000 21.91939  ? 16  GLU A CD   1 
ATOM   251  O OE1  . GLU A 1 19  ? 31.91307 -7.47055  27.77350 1.000 20.71923  ? 16  GLU A OE1  1 
ATOM   252  O OE2  . GLU A 1 19  ? 30.55670 -6.38979  29.09291 1.000 20.09977  ? 16  GLU A OE2  1 
ATOM   253  H H    . GLU A 1 19  ? 32.67323 -6.93100  26.21641 1.000 23.52853  ? 16  GLU A H    1 
ATOM   254  H HA   . GLU A 1 19  ? 31.80855 -5.28699  24.35518 1.000 24.45828  ? 16  GLU A HA   1 
ATOM   255  H HB2  . GLU A 1 19  ? 31.43153 -3.78267  26.24811 1.000 20.97203  ? 16  GLU A HB2  1 
ATOM   256  H HB3  . GLU A 1 19  ? 30.60006 -5.13682  26.23004 1.000 20.97203  ? 16  GLU A HB3  1 
ATOM   257  H HG2  . GLU A 1 19  ? 32.96820 -5.16048  27.65996 1.000 26.16350  ? 16  GLU A HG2  1 
ATOM   258  H HG3  . GLU A 1 19  ? 31.74510 -4.37921  28.30730 1.000 26.16350  ? 16  GLU A HG3  1 
ATOM   259  N N    . MET A 1 20  ? 34.69725 -4.52061  25.48066 1.000 18.86276  ? 17  MET A N    1 
ATOM   260  C CA   . MET A 1 20  ? 35.83227 -3.65421  25.15214 1.000 17.60155  ? 17  MET A CA   1 
ATOM   261  C C    . MET A 1 20  ? 36.26031 -3.82919  23.69146 1.000 19.61581  ? 17  MET A C    1 
ATOM   262  O O    . MET A 1 20  ? 36.60191 -2.84308  23.00358 1.000 18.81655  ? 17  MET A O    1 
ATOM   263  C CB   . MET A 1 20  ? 36.98597 -3.92411  26.09768 1.000 18.66457  ? 17  MET A CB   1 
ATOM   264  C CG   . MET A 1 20  ? 36.68487 -3.69068  27.52232 1.000 18.25366  ? 17  MET A CG   1 
ATOM   265  S SD   . MET A 1 20  ? 38.15610 -3.89988  28.58994 1.000 22.66008  ? 17  MET A SD   1 
ATOM   266  C CE   . MET A 1 20  ? 38.42618 -5.67506  28.70267 1.000 21.39543  ? 17  MET A CE   1 
ATOM   267  H H    . MET A 1 20  ? 34.86686 -5.14900  26.04276 1.000 22.59076  ? 17  MET A H    1 
ATOM   268  H HA   . MET A 1 20  ? 35.56481 -2.73084  25.28160 1.000 21.07731  ? 17  MET A HA   1 
ATOM   269  H HB2  . MET A 1 20  ? 37.25033 -4.85264  26.00363 1.000 22.35294  ? 17  MET A HB2  1 
ATOM   270  H HB3  . MET A 1 20  ? 37.72416 -3.34293  25.85641 1.000 22.35294  ? 17  MET A HB3  1 
ATOM   271  H HG2  . MET A 1 20  ? 36.35842 -2.78403  27.63329 1.000 21.85984  ? 17  MET A HG2  1 
ATOM   272  H HG3  . MET A 1 20  ? 36.00979 -4.32415  27.81195 1.000 21.85984  ? 17  MET A HG3  1 
ATOM   273  H HE1  . MET A 1 20  ? 39.20769 -5.84130  29.25268 1.000 25.62996  ? 17  MET A HE1  1 
ATOM   274  H HE2  . MET A 1 20  ? 37.64558 -6.08843  29.10353 1.000 25.62996  ? 17  MET A HE2  1 
ATOM   275  H HE3  . MET A 1 20  ? 38.56749 -6.03024  27.81116 1.000 25.62996  ? 17  MET A HE3  1 
ATOM   276  N N    . GLU A 1 21  ? 36.20751 -5.06941  23.18100 1.000 20.13658  ? 18  GLU A N    1 
ATOM   277  C CA   . GLU A 1 21  ? 36.60485 -5.37153  21.80353 1.000 17.89598  ? 18  GLU A CA   1 
ATOM   278  C C    . GLU A 1 21  ? 35.57144 -4.87944  20.78776 1.000 20.28635  ? 18  GLU A C    1 
ATOM   279  O O    . GLU A 1 21  ? 35.85483 -4.78868  19.58630 1.000 21.38279  ? 18  GLU A O    1 
ATOM   280  C CB   . GLU A 1 21  ? 36.80540 -6.89861  21.60096 1.000 17.60602  ? 18  GLU A CB   1 
ATOM   281  C CG   . GLU A 1 21  ? 37.91803 -7.42767  22.49302 1.000 21.35445  ? 18  GLU A CG   1 
ATOM   282  C CD   . GLU A 1 21  ? 37.94883 -8.91166  22.54244 1.000 24.25159  ? 18  GLU A CD   1 
ATOM   283  O OE1  . GLU A 1 21  ? 37.33067 -9.56451  21.65149 1.000 20.91174  ? 18  GLU A OE1  1 
ATOM   284  O OE2  . GLU A 1 21  ? 38.58980 -9.45868  23.47787 1.000 21.08069  ? 18  GLU A OE2  1 
ATOM   285  H H    . GLU A 1 21  ? 35.94154 -5.75964  23.61967 1.000 24.11934  ? 18  GLU A H    1 
ATOM   286  H HA   . GLU A 1 21  ? 37.45524 -4.93649  21.63478 1.000 21.43063  ? 18  GLU A HA   1 
ATOM   287  H HB2  . GLU A 1 21  ? 35.98427 -7.36380  21.82510 1.000 21.08267  ? 18  GLU A HB2  1 
ATOM   288  H HB3  . GLU A 1 21  ? 37.04349 -7.07237  20.67682 1.000 21.08267  ? 18  GLU A HB3  1 
ATOM   289  H HG2  . GLU A 1 21  ? 38.77205 -7.11995  22.15118 1.000 25.58079  ? 18  GLU A HG2  1 
ATOM   290  H HG3  . GLU A 1 21  ? 37.78414 -7.09901  23.39577 1.000 25.58079  ? 18  GLU A HG3  1 
ATOM   291  N N    . THR A 1 22  ? 34.38074 -4.56323  21.25672 1.000 19.98997  ? 19  THR A N    1 
ATOM   292  C CA   . THR A 1 22  ? 33.32661 -4.00622  20.42241 1.000 17.16267  ? 19  THR A CA   1 
ATOM   293  C C    . THR A 1 22  ? 33.41195 -2.47717  20.40988 1.000 17.91121  ? 19  THR A C    1 
ATOM   294  O O    . THR A 1 22  ? 33.51809 -1.85700  19.33780 1.000 22.09509  ? 19  THR A O    1 
ATOM   295  C CB   . THR A 1 22  ? 31.96303 -4.47166  20.96258 1.000 21.28040  ? 19  THR A CB   1 
ATOM   296  O OG1  . THR A 1 22  ? 31.89719 -5.91616  20.97609 1.000 22.85960  ? 19  THR A OG1  1 
ATOM   297  C CG2  . THR A 1 22  ? 30.83832 -3.93037  20.11913 1.000 26.38988  ? 19  THR A CG2  1 
ATOM   298  H H    . THR A 1 22  ? 34.14759 -4.66317  22.07846 1.000 23.94342  ? 19  THR A H    1 
ATOM   299  H HA   . THR A 1 22  ? 33.40854 -4.32421  19.50969 1.000 20.55066  ? 19  THR A HA   1 
ATOM   300  H HB   . THR A 1 22  ? 31.85510 -4.13898  21.86732 1.000 25.49193  ? 19  THR A HB   1 
ATOM   301  H HG1  . THR A 1 22  ? 31.15388 -6.16708  21.27629 1.000 27.38698  ? 19  THR A HG1  1 
ATOM   302  H HG21 . THR A 1 22  ? 29.98729 -4.25382  20.45383 1.000 31.62330  ? 19  THR A HG21 1 
ATOM   303  H HG22 . THR A 1 22  ? 30.83961 -2.96078  20.14710 1.000 31.62330  ? 19  THR A HG22 1 
ATOM   304  H HG23 . THR A 1 22  ? 30.94497 -4.21890  19.19919 1.000 31.62330  ? 19  THR A HG23 1 
ATOM   305  N N    . VAL A 1 23  ? 33.47660 -1.84982  21.60722 1.000 19.87122  ? 20  VAL A N    1 
ATOM   306  C CA   . VAL A 1 23  ? 33.39494 -0.39079  21.67517 1.000 20.88872  ? 20  VAL A CA   1 
ATOM   307  C C    . VAL A 1 23  ? 34.65926 0.29630   21.19894 1.000 20.53485  ? 20  VAL A C    1 
ATOM   308  O O    . VAL A 1 23  ? 34.59085 1.36906   20.57871 1.000 21.59824  ? 20  VAL A O    1 
ATOM   309  C CB   . VAL A 1 23  ? 33.05884 0.03977   23.11592 1.000 23.38521  ? 20  VAL A CB   1 
ATOM   310  C CG1  . VAL A 1 23  ? 33.16544 1.52466   23.29687 1.000 29.74571  ? 20  VAL A CG1  1 
ATOM   311  C CG2  . VAL A 1 23  ? 31.63421 -0.39538  23.46813 1.000 25.28265  ? 20  VAL A CG2  1 
ATOM   312  H H    . VAL A 1 23  ? 33.56504 -2.24279  22.36706 1.000 23.80091  ? 20  VAL A H    1 
ATOM   313  H HA   . VAL A 1 23  ? 32.68626 -0.12111  21.07024 1.000 25.02191  ? 20  VAL A HA   1 
ATOM   314  H HB   . VAL A 1 23  ? 33.69958 -0.38523  23.70729 1.000 28.01770  ? 20  VAL A HB   1 
ATOM   315  H HG11 . VAL A 1 23  ? 32.89014 1.75351   24.19839 1.000 35.65030  ? 20  VAL A HG11 1 
ATOM   316  H HG12 . VAL A 1 23  ? 34.08590 1.79500   23.15343 1.000 35.65030  ? 20  VAL A HG12 1 
ATOM   317  H HG13 . VAL A 1 23  ? 32.58764 1.96354   22.65311 1.000 35.65030  ? 20  VAL A HG13 1 
ATOM   318  H HG21 . VAL A 1 23  ? 31.44235 -0.13737  24.38329 1.000 30.29462  ? 20  VAL A HG21 1 
ATOM   319  H HG22 . VAL A 1 23  ? 31.01254 0.04037   22.86435 1.000 30.29462  ? 20  VAL A HG22 1 
ATOM   320  H HG23 . VAL A 1 23  ? 31.56599 -1.35846  23.37474 1.000 30.29462  ? 20  VAL A HG23 1 
ATOM   321  N N    . ILE A 1 24  ? 35.85954 -0.25081  21.49043 1.000 18.82633  ? 21  ILE A N    1 
ATOM   322  C CA   . ILE A 1 24  ? 37.07698 0.42759   21.02181 1.000 19.08892  ? 21  ILE A CA   1 
ATOM   323  C C    . ILE A 1 24  ? 37.13048 0.54015   19.49133 1.000 19.23537  ? 21  ILE A C    1 
ATOM   324  O O    . ILE A 1 24  ? 37.30695 1.65612   18.97476 1.000 18.64431  ? 21  ILE A O    1 
ATOM   325  C CB   . ILE A 1 24  ? 38.32512 -0.24740  21.62458 1.000 19.40721  ? 21  ILE A CB   1 
ATOM   326  C CG1  . ILE A 1 24  ? 38.34168 0.00380   23.12279 1.000 20.99617  ? 21  ILE A CG1  1 
ATOM   327  C CG2  . ILE A 1 24  ? 39.59266 0.30910   21.02327 1.000 21.69467  ? 21  ILE A CG2  1 
ATOM   328  C CD1  . ILE A 1 24  ? 39.32433 -0.89139  23.89706 1.000 26.25438  ? 21  ILE A CD1  1 
ATOM   329  H H    . ILE A 1 24  ? 35.98492 -0.97623  21.93500 1.000 22.54705  ? 21  ILE A H    1 
ATOM   330  H HA   . ILE A 1 24  ? 37.04778 1.33359   21.36707 1.000 22.86216  ? 21  ILE A HA   1 
ATOM   331  H HB   . ILE A 1 24  ? 38.28198 -1.19706  21.43171 1.000 23.24410  ? 21  ILE A HB   1 
ATOM   332  H HG12 . ILE A 1 24  ? 38.59624 0.92642   23.28049 1.000 25.15085  ? 21  ILE A HG12 1 
ATOM   333  H HG13 . ILE A 1 24  ? 37.45298 -0.16005  23.47530 1.000 25.15085  ? 21  ILE A HG13 1 
ATOM   334  H HG21 . ILE A 1 24  ? 40.35574 -0.09301  21.46701 1.000 25.98905  ? 21  ILE A HG21 1 
ATOM   335  H HG22 . ILE A 1 24  ? 39.61191 0.09879   20.07654 1.000 25.98905  ? 21  ILE A HG22 1 
ATOM   336  H HG23 . ILE A 1 24  ? 39.60599 1.27085   21.14880 1.000 25.98905  ? 21  ILE A HG23 1 
ATOM   337  H HD11 . ILE A 1 24  ? 39.26065 -0.68589  24.84291 1.000 31.46070  ? 21  ILE A HD11 1 
ATOM   338  H HD12 . ILE A 1 24  ? 39.09251 -1.82079  23.74416 1.000 31.46070  ? 21  ILE A HD12 1 
ATOM   339  H HD13 . ILE A 1 24  ? 40.22500 -0.71881  23.58097 1.000 31.46070  ? 21  ILE A HD13 1 
ATOM   340  N N    . PRO A 1 25  ? 36.93863 -0.52925  18.71946 1.000 17.49445  ? 22  PRO A N    1 
ATOM   341  C CA   . PRO A 1 25  ? 36.95199 -0.31162  17.25332 1.000 21.17452  ? 22  PRO A CA   1 
ATOM   342  C C    . PRO A 1 25  ? 35.83850 0.60778   16.74439 1.000 20.21050  ? 22  PRO A C    1 
ATOM   343  O O    . PRO A 1 25  ? 36.06031 1.35389   15.77653 1.000 19.39852  ? 22  PRO A O    1 
ATOM   344  C CB   . PRO A 1 25  ? 36.84108 -1.73132  16.66552 1.000 23.71490  ? 22  PRO A CB   1 
ATOM   345  C CG   . PRO A 1 25  ? 37.24451 -2.66986  17.80897 1.000 23.98462  ? 22  PRO A CG   1 
ATOM   346  C CD   . PRO A 1 25  ? 36.89435 -1.95217  19.10039 1.000 20.65638  ? 22  PRO A CD   1 
ATOM   347  H HA   . PRO A 1 25  ? 37.80996 0.06676   17.00510 1.000 25.36487  ? 22  PRO A HA   1 
ATOM   348  H HB2  . PRO A 1 25  ? 35.92870 -1.90094  16.38322 1.000 28.41333  ? 22  PRO A HB2  1 
ATOM   349  H HB3  . PRO A 1 25  ? 37.44430 -1.82407  15.91158 1.000 28.41333  ? 22  PRO A HB3  1 
ATOM   350  H HG2  . PRO A 1 25  ? 36.75026 -3.50130  17.73598 1.000 28.73700  ? 22  PRO A HG2  1 
ATOM   351  H HG3  . PRO A 1 25  ? 38.19744 -2.84532  17.76382 1.000 28.73700  ? 22  PRO A HG3  1 
ATOM   352  H HD2  . PRO A 1 25  ? 36.00734 -2.20089  19.40409 1.000 24.74311  ? 22  PRO A HD2  1 
ATOM   353  H HD3  . PRO A 1 25  ? 37.54771 -2.14528  19.79085 1.000 24.74311  ? 22  PRO A HD3  1 
ATOM   354  N N    . VAL A 1 26  ? 34.63518 0.52415   17.30318 1.000 18.76751  ? 23  VAL A N    1 
ATOM   355  C CA   . VAL A 1 26  ? 33.53830 1.39429   16.84116 1.000 15.31298  ? 23  VAL A CA   1 
ATOM   356  C C    . VAL A 1 26  ? 33.91637 2.85943   17.04142 1.000 18.95379  ? 23  VAL A C    1 
ATOM   357  O O    . VAL A 1 26  ? 33.74933 3.70553   16.15480 1.000 20.75754  ? 23  VAL A O    1 
ATOM   358  C CB   . VAL A 1 26  ? 32.23786 1.03926   17.58346 1.000 18.18740  ? 23  VAL A CB   1 
ATOM   359  C CG1  . VAL A 1 26  ? 31.14984 2.09953   17.31967 1.000 21.79444  ? 23  VAL A CG1  1 
ATOM   360  C CG2  . VAL A 1 26  ? 31.71918 -0.33508  17.15097 1.000 22.68708  ? 23  VAL A CG2  1 
ATOM   361  H H    . VAL A 1 26  ? 34.42344 -0.01449  17.93929 1.000 22.47646  ? 23  VAL A H    1 
ATOM   362  H HA   . VAL A 1 26  ? 33.39455 1.24819   15.89306 1.000 18.33102  ? 23  VAL A HA   1 
ATOM   363  H HB   . VAL A 1 26  ? 32.43358 1.01661   18.53324 1.000 21.78033  ? 23  VAL A HB   1 
ATOM   364  H HG11 . VAL A 1 26  ? 30.35137 1.86319   17.81716 1.000 26.10877  ? 23  VAL A HG11 1 
ATOM   365  H HG12 . VAL A 1 26  ? 31.47605 2.96573   17.60979 1.000 26.10877  ? 23  VAL A HG12 1 
ATOM   366  H HG13 . VAL A 1 26  ? 30.95358 2.12111   16.36998 1.000 26.10877  ? 23  VAL A HG13 1 
ATOM   367  H HG21 . VAL A 1 26  ? 30.88555 -0.51746  17.61216 1.000 27.17995  ? 23  VAL A HG21 1 
ATOM   368  H HG22 . VAL A 1 26  ? 31.57247 -0.32985  16.19214 1.000 27.17995  ? 23  VAL A HG22 1 
ATOM   369  H HG23 . VAL A 1 26  ? 32.37862 -1.00822  17.38103 1.000 27.17995  ? 23  VAL A HG23 1 
ATOM   370  N N    . ASP A 1 27  ? 34.37266 3.19617   18.26285 1.000 19.57571  ? 24  ASP A N    1 
ATOM   371  C CA   . ASP A 1 27  ? 34.73189 4.57501   18.59386 1.000 17.91430  ? 24  ASP A CA   1 
ATOM   372  C C    . ASP A 1 27  ? 35.89728 5.06308   17.70775 1.000 19.80262  ? 24  ASP A C    1 
ATOM   373  O O    . ASP A 1 27  ? 35.82112 6.11809   17.06814 1.000 19.55012  ? 24  ASP A O    1 
ATOM   374  C CB   . ASP A 1 27  ? 35.06573 4.57721   20.09530 1.000 18.38379  ? 24  ASP A CB   1 
ATOM   375  C CG   . ASP A 1 27  ? 35.33430 5.92622   20.68050 1.000 19.80474  ? 24  ASP A CG   1 
ATOM   376  O OD1  . ASP A 1 27  ? 36.03419 6.71819   20.04857 1.000 19.94041  ? 24  ASP A OD1  1 
ATOM   377  O OD2  . ASP A 1 27  ? 34.97191 6.12973   21.89218 1.000 20.13298  ? 24  ASP A OD2  1 
ATOM   378  H H    . ASP A 1 27  ? 34.48099 2.64224   18.91171 1.000 23.44631  ? 24  ASP A H    1 
ATOM   379  H HA   . ASP A 1 27  ? 34.00833 5.20012   18.43078 1.000 21.45261  ? 24  ASP A HA   1 
ATOM   380  H HB2  . ASP A 1 27  ? 34.31566 4.19554   20.57762 1.000 22.01600  ? 24  ASP A HB2  1 
ATOM   381  H HB3  . ASP A 1 27  ? 35.85924 4.03700   20.23464 1.000 22.01600  ? 24  ASP A HB3  1 
ATOM   382  N N    . VAL A 1 28  ? 36.96038 4.25971   17.59044 1.000 18.73260  ? 25  VAL A N    1 
ATOM   383  C CA   . VAL A 1 28  ? 38.11488 4.70937   16.82344 1.000 16.85335  ? 25  VAL A CA   1 
ATOM   384  C C    . VAL A 1 28  ? 37.77061 4.84607   15.34738 1.000 17.75465  ? 25  VAL A C    1 
ATOM   385  O O    . VAL A 1 28  ? 38.23088 5.79127   14.67992 1.000 19.05183  ? 25  VAL A O    1 
ATOM   386  C CB   . VAL A 1 28  ? 39.28933 3.74244   17.02749 1.000 19.39677  ? 25  VAL A CB   1 
ATOM   387  C CG1  . VAL A 1 28  ? 40.44860 4.04686   16.05090 1.000 23.48430  ? 25  VAL A CG1  1 
ATOM   388  C CG2  . VAL A 1 28  ? 39.82101 3.85125   18.44597 1.000 20.23845  ? 25  VAL A CG2  1 
ATOM   389  H H    . VAL A 1 28  ? 37.03195 3.47537   17.93582 1.000 22.43456  ? 25  VAL A H    1 
ATOM   390  H HA   . VAL A 1 28  ? 38.37118 5.58566   17.15107 1.000 20.17947  ? 25  VAL A HA   1 
ATOM   391  H HB   . VAL A 1 28  ? 38.96174 2.84492   16.86002 1.000 23.23158  ? 25  VAL A HB   1 
ATOM   392  H HG11 . VAL A 1 28  ? 41.15972 3.40295   16.19437 1.000 28.13661  ? 25  VAL A HG11 1 
ATOM   393  H HG12 . VAL A 1 28  ? 40.12045 3.97992   15.14055 1.000 28.13661  ? 25  VAL A HG12 1 
ATOM   394  H HG13 . VAL A 1 28  ? 40.77601 4.94426   16.21934 1.000 28.13661  ? 25  VAL A HG13 1 
ATOM   395  H HG21 . VAL A 1 28  ? 40.58129 3.25701   18.54471 1.000 24.24159  ? 25  VAL A HG21 1 
ATOM   396  H HG22 . VAL A 1 28  ? 40.09349 4.76733   18.61169 1.000 24.24159  ? 25  VAL A HG22 1 
ATOM   397  H HG23 . VAL A 1 28  ? 39.11993 3.59731   19.06636 1.000 24.24159  ? 25  VAL A HG23 1 
ATOM   398  N N    . MET A 1 29  ? 36.96660 3.92609   14.81186 1.000 19.28904  ? 26  MET A N    1 
ATOM   399  C CA   . MET A 1 29  ? 36.56589 4.06790   13.40795 1.000 21.31434  ? 26  MET A CA   1 
ATOM   400  C C    . MET A 1 29  ? 35.72537 5.31756   13.17060 1.000 20.27473  ? 26  MET A C    1 
ATOM   401  O O    . MET A 1 29  ? 35.89181 5.98178   12.13276 1.000 19.17589  ? 26  MET A O    1 
ATOM   402  C CB   . MET A 1 29  ? 35.83147 2.82813   12.90334 1.000 21.12494  ? 26  MET A CB   1 
ATOM   403  C CG   . MET A 1 29  ? 36.75480 1.65010   12.66562 1.000 23.00674  ? 26  MET A CG   1 
ATOM   404  S SD   . MET A 1 29  ? 35.93551 0.25938   11.83293 1.000 23.12191  ? 26  MET A SD   1 
ATOM   405  C CE   . MET A 1 29  ? 34.81708 -0.36631  13.03754 1.000 23.57517  ? 26  MET A CE   1 
ATOM   406  H H    . MET A 1 29  ? 36.65103 3.23829   15.22047 1.000 23.10229  ? 26  MET A H    1 
ATOM   407  H HA   . MET A 1 29  ? 37.38455 4.14278   12.89309 1.000 25.53266  ? 26  MET A HA   1 
ATOM   408  H HB2  . MET A 1 29  ? 35.17130 2.56301   13.56273 1.000 25.30538  ? 26  MET A HB2  1 
ATOM   409  H HB3  . MET A 1 29  ? 35.39485 3.04073   12.06366 1.000 25.30538  ? 26  MET A HB3  1 
ATOM   410  H HG2  . MET A 1 29  ? 37.49484 1.93766   12.10835 1.000 27.56354  ? 26  MET A HG2  1 
ATOM   411  H HG3  . MET A 1 29  ? 37.08666 1.33285   13.52009 1.000 27.56354  ? 26  MET A HG3  1 
ATOM   412  H HE1  . MET A 1 29  ? 34.31052 -1.09659  12.64899 1.000 28.24565  ? 26  MET A HE1  1 
ATOM   413  H HE2  . MET A 1 29  ? 35.32201 -0.68412  13.80236 1.000 28.24565  ? 26  MET A HE2  1 
ATOM   414  H HE3  . MET A 1 29  ? 34.21628 0.34476   13.31015 1.000 28.24565  ? 26  MET A HE3  1 
ATOM   415  N N    . ARG A 1 30  ? 34.81863 5.64204   14.08036 1.000 18.62738  ? 27  ARG A N    1 
ATOM   416  C CA   . ARG A 1 30  ? 34.02926 6.87463   13.93748 1.000 19.75888  ? 27  ARG A CA   1 
ATOM   417  C C    . ARG A 1 30  ? 34.90266 8.12378   14.08793 1.000 24.39519  ? 27  ARG A C    1 
ATOM   418  O O    . ARG A 1 30  ? 34.66534 9.12450   13.39289 1.000 22.83914  ? 27  ARG A O    1 
ATOM   419  C CB   . ARG A 1 30  ? 32.85589 6.85721   14.93164 1.000 18.19484  ? 27  ARG A CB   1 
ATOM   420  C CG   . ARG A 1 30  ? 31.71500 5.96079   14.46968 1.000 21.75227  ? 27  ARG A CG   1 
ATOM   421  C CD   . ARG A 1 30  ? 30.53398 5.89603   15.42028 1.000 21.98746  ? 27  ARG A CD   1 
ATOM   422  N NE   . ARG A 1 30  ? 29.44019 5.09156   14.86802 1.000 21.25315  ? 27  ARG A NE   1 
ATOM   423  C CZ   . ARG A 1 30  ? 28.57170 4.39701   15.59999 1.000 23.77896  ? 27  ARG A CZ   1 
ATOM   424  N NH1  . ARG A 1 30  ? 28.58761 4.43574   16.92321 1.000 22.41616  ? 27  ARG A NH1  1 
ATOM   425  N NH2  . ARG A 1 30  ? 27.66349 3.61545   14.98582 1.000 23.05232  ? 27  ARG A NH2  1 
ATOM   426  H H    . ARG A 1 30  ? 34.63694 5.17920   14.78205 1.000 22.30830  ? 27  ARG A H    1 
ATOM   427  H HA   . ARG A 1 30  ? 33.64311 6.91568   13.04860 1.000 23.66611  ? 27  ARG A HA   1 
ATOM   428  H HB2  . ARG A 1 30  ? 33.17092 6.52740   15.78773 1.000 21.78926  ? 27  ARG A HB2  1 
ATOM   429  H HB3  . ARG A 1 30  ? 32.51060 7.75832   15.02995 1.000 21.78926  ? 27  ARG A HB3  1 
ATOM   430  H HG2  . ARG A 1 30  ? 31.38645 6.29238   13.61938 1.000 26.05817  ? 27  ARG A HG2  1 
ATOM   431  H HG3  . ARG A 1 30  ? 32.05431 5.05812   14.36503 1.000 26.05817  ? 27  ARG A HG3  1 
ATOM   432  H HD2  . ARG A 1 30  ? 30.81672 5.49293   16.25603 1.000 26.34040  ? 27  ARG A HD2  1 
ATOM   433  H HD3  . ARG A 1 30  ? 30.20159 6.79313   15.58037 1.000 26.34040  ? 27  ARG A HD3  1 
ATOM   434  H HE   . ARG A 1 30  ? 29.35354 5.06652   14.01276 1.000 25.45924  ? 27  ARG A HE   1 
ATOM   435  H HH11 . ARG A 1 30  ? 29.16977 4.91881   17.33228 1.000 26.85484  ? 27  ARG A HH11 1 
ATOM   436  H HH12 . ARG A 1 30  ? 28.01580 3.97783   17.37370 1.000 26.85484  ? 27  ARG A HH12 1 
ATOM   437  H HH21 . ARG A 1 30  ? 27.64757 3.56781   14.12729 1.000 27.61823  ? 27  ARG A HH21 1 
ATOM   438  H HH22 . ARG A 1 30  ? 27.09930 3.16388   15.45207 1.000 27.61823  ? 27  ARG A HH22 1 
ATOM   439  N N    . ARG A 1 31  ? 35.97159 8.06861   14.90091 1.000 20.29048  ? 28  ARG A N    1 
ATOM   440  C CA   . ARG A 1 31  ? 36.91425 9.18736   14.95592 1.000 20.31839  ? 28  ARG A CA   1 
ATOM   441  C C    . ARG A 1 31  ? 37.56692 9.41065   13.61929 1.000 19.92923  ? 28  ARG A C    1 
ATOM   442  O O    . ARG A 1 31  ? 37.97232 10.53953  13.30194 1.000 21.59200  ? 28  ARG A O    1 
ATOM   443  C CB   . ARG A 1 31  ? 37.97856 8.95533   16.01126 1.000 17.89474  ? 28  ARG A CB   1 
ATOM   444  C CG   . ARG A 1 31  ? 37.46924 9.14735   17.43079 1.000 19.06256  ? 28  ARG A CG   1 
ATOM   445  C CD   . ARG A 1 31  ? 38.47803 8.68240   18.47758 1.000 21.83651  ? 28  ARG A CD   1 
ATOM   446  N NE   . ARG A 1 31  ? 37.98011 8.89085   19.84073 1.000 21.07229  ? 28  ARG A NE   1 
ATOM   447  C CZ   . ARG A 1 31  ? 38.40417 9.84700   20.66262 1.000 20.87294  ? 28  ARG A CZ   1 
ATOM   448  N NH1  . ARG A 1 31  ? 39.33882 10.71288  20.30770 1.000 21.30038  ? 28  ARG A NH1  1 
ATOM   449  N NH2  . ARG A 1 31  ? 37.87211 9.94204   21.87446 1.000 21.60253  ? 28  ARG A NH2  1 
ATOM   450  H H    . ARG A 1 31  ? 36.16570 7.40867   15.41706 1.000 24.30403  ? 28  ARG A H    1 
ATOM   451  H HA   . ARG A 1 31  ? 36.42217 9.98449   15.20758 1.000 24.33751  ? 28  ARG A HA   1 
ATOM   452  H HB2  . ARG A 1 31  ? 38.30543 8.04549   15.93229 1.000 21.42914  ? 28  ARG A HB2  1 
ATOM   453  H HB3  . ARG A 1 31  ? 38.70460 9.58233   15.86762 1.000 21.42914  ? 28  ARG A HB3  1 
ATOM   454  H HG2  . ARG A 1 31  ? 37.29231 10.08926  17.58049 1.000 22.83053  ? 28  ARG A HG2  1 
ATOM   455  H HG3  . ARG A 1 31  ? 36.65469 8.63398   17.54857 1.000 22.83053  ? 28  ARG A HG3  1 
ATOM   456  H HD2  . ARG A 1 31  ? 38.65010 7.73529   18.35809 1.000 26.15927  ? 28  ARG A HD2  1 
ATOM   457  H HD3  . ARG A 1 31  ? 39.30134 9.18478   18.37431 1.000 26.15927  ? 28  ARG A HD3  1 
ATOM   458  H HE   . ARG A 1 31  ? 37.37069 8.35714   20.12944 1.000 25.24220  ? 28  ARG A HE   1 
ATOM   459  H HH11 . ARG A 1 31  ? 39.69169 10.66786  19.52472 1.000 25.51590  ? 28  ARG A HH11 1 
ATOM   460  H HH12 . ARG A 1 31  ? 39.59370 11.32092  20.85990 1.000 25.51590  ? 28  ARG A HH12 1 
ATOM   461  H HH21 . ARG A 1 31  ? 37.26076 9.38937   22.12022 1.000 25.87848  ? 28  ARG A HH21 1 
ATOM   462  H HH22 . ARG A 1 31  ? 38.13863 10.55631  22.41412 1.000 25.87848  ? 28  ARG A HH22 1 
ATOM   463  N N    . ALA A 1 32  ? 37.74072 8.34669   12.85087 1.000 21.41842  ? 29  ALA A N    1 
ATOM   464  C CA   . ALA A 1 32  ? 38.37841 8.42899   11.53733 1.000 20.40624  ? 29  ALA A CA   1 
ATOM   465  C C    . ALA A 1 32  ? 37.38054 8.75821   10.44060 1.000 22.90450  ? 29  ALA A C    1 
ATOM   466  O O    . ALA A 1 32  ? 37.74483 8.78298   9.26223  1.000 26.82752  ? 29  ALA A O    1 
ATOM   467  C CB   . ALA A 1 32  ? 39.06589 7.09553   11.23165 1.000 20.77340  ? 29  ALA A CB   1 
ATOM   468  H H    . ALA A 1 32  ? 37.49534 7.55151   13.06784 1.000 25.65755  ? 29  ALA A H    1 
ATOM   469  H HA   . ALA A 1 32  ? 39.05329 9.12568   11.54509 1.000 24.44294  ? 29  ALA A HA   1 
ATOM   470  H HB1  . ALA A 1 32  ? 39.48857 7.15059   10.36033 1.000 24.88353  ? 29  ALA A HB1  1 
ATOM   471  H HB2  . ALA A 1 32  ? 39.73396 6.92118   11.91296 1.000 24.88353  ? 29  ALA A HB2  1 
ATOM   472  H HB3  . ALA A 1 32  ? 38.40053 6.38970   11.23251 1.000 24.88353  ? 29  ALA A HB3  1 
ATOM   473  N N    . GLY A 1 33  ? 36.15267 9.05700   10.79113 1.000 24.09833  ? 30  GLY A N    1 
ATOM   474  C CA   . GLY A 1 33  ? 35.15277 9.44406   9.77759  1.000 24.36363  ? 30  GLY A CA   1 
ATOM   475  C C    . GLY A 1 33  ? 34.54165 8.30599   9.00968  1.000 26.48170  ? 30  GLY A C    1 
ATOM   476  O O    . GLY A 1 33  ? 33.86408 8.55242   8.01717  1.000 27.31298  ? 30  GLY A O    1 
ATOM   477  H H    . GLY A 1 33  ? 35.85824 9.04853   11.59912 1.000 28.87344  ? 30  GLY A H    1 
ATOM   478  H HA2  . GLY A 1 33  ? 34.43273 9.91989   10.22034 1.000 29.19180  ? 30  GLY A HA2  1 
ATOM   479  H HA3  . GLY A 1 33  ? 35.57609 10.03687  9.13705  1.000 29.19180  ? 30  GLY A HA3  1 
ATOM   480  N N    . ILE A 1 34  ? 34.75345 7.07154   9.44245  1.000 20.59482  ? 31  ILE A N    1 
ATOM   481  C CA   . ILE A 1 34  ? 34.12799 5.89910   8.84218  1.000 23.77680  ? 31  ILE A CA   1 
ATOM   482  C C    . ILE A 1 34  ? 32.69701 5.78737   9.33715  1.000 23.34925  ? 31  ILE A C    1 
ATOM   483  O O    . ILE A 1 34  ? 32.38707 6.00795   10.52768 1.000 25.23131  ? 31  ILE A O    1 
ATOM   484  C CB   . ILE A 1 34  ? 34.95723 4.64165   9.19948  1.000 21.68698  ? 31  ILE A CB   1 
ATOM   485  C CG1  . ILE A 1 34  ? 36.34280 4.73042   8.56483  1.000 27.18900  ? 31  ILE A CG1  1 
ATOM   486  C CG2  . ILE A 1 34  ? 34.20931 3.36969   8.75949  1.000 27.02247  ? 31  ILE A CG2  1 
ATOM   487  C CD1  . ILE A 1 34  ? 37.36528 3.74985   9.23343  1.000 28.43065  ? 31  ILE A CD1  1 
ATOM   488  H H    . ILE A 1 34  ? 35.27043 6.87858   10.10207 1.000 24.66923  ? 31  ILE A H    1 
ATOM   489  H HA   . ILE A 1 34  ? 34.10008 5.99215   7.87706  1.000 28.48761  ? 31  ILE A HA   1 
ATOM   490  H HB   . ILE A 1 34  ? 35.07392 4.59894   10.16149 1.000 25.97982  ? 31  ILE A HB   1 
ATOM   491  H HG12 . ILE A 1 34  ? 36.27655 4.50314   7.62416  1.000 32.58225  ? 31  ILE A HG12 1 
ATOM   492  H HG13 . ILE A 1 34  ? 36.68073 5.63414   8.66478  1.000 32.58225  ? 31  ILE A HG13 1 
ATOM   493  H HG21 . ILE A 1 34  ? 34.71803 2.59205   9.03764  1.000 32.38242  ? 31  ILE A HG21 1 
ATOM   494  H HG22 . ILE A 1 34  ? 33.33341 3.35831   9.17611  1.000 32.38242  ? 31  ILE A HG22 1 
ATOM   495  H HG23 . ILE A 1 34  ? 34.11629 3.37608   7.79398  1.000 32.38242  ? 31  ILE A HG23 1 
ATOM   496  H HD11 . ILE A 1 34  ? 38.23053 3.85780   8.80846  1.000 34.07223  ? 31  ILE A HD11 1 
ATOM   497  H HD12 . ILE A 1 34  ? 37.43231 3.95938   10.17815 1.000 34.07223  ? 31  ILE A HD12 1 
ATOM   498  H HD13 . ILE A 1 34  ? 37.05138 2.83933   9.11802  1.000 34.07223  ? 31  ILE A HD13 1 
ATOM   499  N N    . LYS A 1 35  ? 31.77505 5.43407   8.44025  1.000 22.95762  ? 32  LYS A N    1 
ATOM   500  C CA   A LYS A 1 35  ? 30.39159 5.22421   8.84332  0.388 22.11059  ? 32  LYS A CA   1 
ATOM   501  C CA   B LYS A 1 35  ? 30.39527 5.22626   8.84264  0.612 21.66279  ? 32  LYS A CA   1 
ATOM   502  C C    . LYS A 1 35  ? 30.22696 3.79350   9.32860  1.000 25.84112  ? 32  LYS A C    1 
ATOM   503  O O    . LYS A 1 35  ? 30.32888 2.84300   8.53752  1.000 27.09835  ? 32  LYS A O    1 
ATOM   504  C CB   A LYS A 1 35  ? 29.44308 5.53484   7.68718  0.388 29.44350  ? 32  LYS A CB   1 
ATOM   505  C CB   B LYS A 1 35  ? 29.46580 5.54243   7.65966  0.612 29.57103  ? 32  LYS A CB   1 
ATOM   506  C CG   A LYS A 1 35  ? 29.27305 7.01530   7.47151  0.388 31.08060  ? 32  LYS A CG   1 
ATOM   507  C CG   B LYS A 1 35  ? 27.98931 5.48099   7.99386  0.612 31.93751  ? 32  LYS A CG   1 
ATOM   508  C CD   A LYS A 1 35  ? 27.86385 7.32963   6.99030  0.388 54.61277  ? 32  LYS A CD   1 
ATOM   509  C CD   B LYS A 1 35  ? 27.10389 5.76906   6.76922  0.612 45.56356  ? 32  LYS A CD   1 
ATOM   510  C CE   A LYS A 1 35  ? 27.64258 6.90661   5.54518  0.388 60.66743  ? 32  LYS A CE   1 
ATOM   511  C CE   B LYS A 1 35  ? 27.51384 7.03033   6.00726  0.612 60.85733  ? 32  LYS A CE   1 
ATOM   512  N NZ   A LYS A 1 35  ? 26.24247 7.16409   5.09157  0.388 65.59606  ? 32  LYS A NZ   1 
ATOM   513  N NZ   B LYS A 1 35  ? 26.64917 7.29223   4.81258  0.612 69.38749  ? 32  LYS A NZ   1 
ATOM   514  H HB2  A LYS A 1 35  ? 29.79945 5.14923   6.87158  0.388 35.28765  ? 32  LYS A HB2  1 
ATOM   515  H HB2  B LYS A 1 35  ? 29.65889 6.43948   7.34514  0.612 35.44069  ? 32  LYS A HB2  1 
ATOM   516  H HB3  A LYS A 1 35  ? 28.57165 5.15518   7.88048  0.388 35.28765  ? 32  LYS A HB3  1 
ATOM   517  H HB3  B LYS A 1 35  ? 29.63420 4.89967   6.95298  0.612 35.44069  ? 32  LYS A HB3  1 
ATOM   518  H HG2  A LYS A 1 35  ? 29.42553 7.48449   8.30667  0.388 37.25217  ? 32  LYS A HG2  1 
ATOM   519  H HG2  B LYS A 1 35  ? 27.77321 4.59363   8.32066  0.612 38.28047  ? 32  LYS A HG2  1 
ATOM   520  H HG3  A LYS A 1 35  ? 29.90330 7.31987   6.80001  0.388 37.25217  ? 32  LYS A HG3  1 
ATOM   521  H HG3  B LYS A 1 35  ? 27.78869 6.14295   8.67390  0.612 38.28047  ? 32  LYS A HG3  1 
ATOM   522  H HD2  A LYS A 1 35  ? 27.22453 6.85577   7.54494  0.388 65.49077  ? 32  LYS A HD2  1 
ATOM   523  H HD2  B LYS A 1 35  ? 27.16226 5.01966   6.15612  0.612 54.63172  ? 32  LYS A HD2  1 
ATOM   524  H HD3  A LYS A 1 35  ? 27.71190 8.28568   7.05176  0.388 65.49077  ? 32  LYS A HD3  1 
ATOM   525  H HD3  B LYS A 1 35  ? 26.18732 5.88540   7.06465  0.612 54.63172  ? 32  LYS A HD3  1 
ATOM   526  H HE2  A LYS A 1 35  ? 28.24331 7.40700   4.97104  0.388 72.75637  ? 32  LYS A HE2  1 
ATOM   527  H HE2  B LYS A 1 35  ? 27.44493 7.79469   6.60048  0.612 72.98425  ? 32  LYS A HE2  1 
ATOM   528  H HE3  A LYS A 1 35  ? 27.81785 5.95631   5.46084  0.388 72.75637  ? 32  LYS A HE3  1 
ATOM   529  H HE3  B LYS A 1 35  ? 28.42827 6.93071   5.69938  0.612 72.98425  ? 32  LYS A HE3  1 
ATOM   530  H HZ1  A LYS A 1 35  ? 26.14328 6.90257   4.24667  0.388 78.67072  ? 32  LYS A HZ1  1 
ATOM   531  H HZ1  B LYS A 1 35  ? 26.91239 8.03772   4.40386  0.612 83.22043  ? 32  LYS A HZ1  1 
ATOM   532  H HZ2  A LYS A 1 35  ? 25.66934 6.71393   5.60244  0.388 78.67072  ? 32  LYS A HZ2  1 
ATOM   533  H HZ2  B LYS A 1 35  ? 26.70704 6.61316   4.24020  0.612 83.22043  ? 32  LYS A HZ2  1 
ATOM   534  H HZ3  A LYS A 1 35  ? 26.05905 8.03313   5.14837  0.388 78.67072  ? 32  LYS A HZ3  1 
ATOM   535  H HZ3  B LYS A 1 35  ? 25.80092 7.38547   5.06531  0.612 83.22043  ? 32  LYS A HZ3  1 
ATOM   536  N N    . VAL A 1 36  ? 29.95672 3.63900   10.62652 1.000 22.78772  ? 33  VAL A N    1 
ATOM   537  C CA   . VAL A 1 36  ? 29.91747 2.33567   11.29722 1.000 21.40612  ? 33  VAL A CA   1 
ATOM   538  C C    . VAL A 1 36  ? 28.48170 1.96872   11.59786 1.000 21.99399  ? 33  VAL A C    1 
ATOM   539  O O    . VAL A 1 36  ? 27.73779 2.76169   12.17891 1.000 24.16511  ? 33  VAL A O    1 
ATOM   540  C CB   . VAL A 1 36  ? 30.75778 2.34509   12.59018 1.000 20.33418  ? 33  VAL A CB   1 
ATOM   541  C CG1  . VAL A 1 36  ? 30.73714 0.98388   13.30733 1.000 22.90021  ? 33  VAL A CG1  1 
ATOM   542  C CG2  . VAL A 1 36  ? 32.15520 2.78395   12.26964 1.000 23.83919  ? 33  VAL A CG2  1 
ATOM   543  H H    . VAL A 1 36  ? 29.78742 4.29501   11.15622 1.000 27.30071  ? 33  VAL A H    1 
ATOM   544  H HA   . VAL A 1 36  ? 30.27468 1.66656   10.69258 1.000 25.64279  ? 33  VAL A HA   1 
ATOM   545  H HB   . VAL A 1 36  ? 30.36739 2.97624   13.21479 1.000 24.35647  ? 33  VAL A HB   1 
ATOM   546  H HG11 . VAL A 1 36  ? 31.32294 1.02477   14.07938 1.000 27.43570  ? 33  VAL A HG11 1 
ATOM   547  H HG12 . VAL A 1 36  ? 29.82989 0.78978   13.59039 1.000 27.43570  ? 33  VAL A HG12 1 
ATOM   548  H HG13 . VAL A 1 36  ? 31.04589 0.29896   12.69376 1.000 27.43570  ? 33  VAL A HG13 1 
ATOM   549  H HG21 . VAL A 1 36  ? 32.67029 2.82242   13.09068 1.000 28.56248  ? 33  VAL A HG21 1 
ATOM   550  H HG22 . VAL A 1 36  ? 32.55439 2.14532   11.65834 1.000 28.56248  ? 33  VAL A HG22 1 
ATOM   551  H HG23 . VAL A 1 36  ? 32.12390 3.66142   11.85737 1.000 28.56248  ? 33  VAL A HG23 1 
ATOM   552  N N    . THR A 1 37  ? 28.09605 0.74544   11.24238 1.000 20.06350  ? 34  THR A N    1 
ATOM   553  C CA   . THR A 1 37  ? 26.84961 0.19022   11.70984 1.000 20.93628  ? 34  THR A CA   1 
ATOM   554  C C    . THR A 1 37  ? 27.09979 -0.92947  12.69519 1.000 25.11706  ? 34  THR A C    1 
ATOM   555  O O    . THR A 1 37  ? 27.73006 -1.92521  12.32581 1.000 24.57515  ? 34  THR A O    1 
ATOM   556  C CB   . THR A 1 37  ? 26.03512 -0.35100  10.52192 1.000 27.46183  ? 34  THR A CB   1 
ATOM   557  O OG1  . THR A 1 37  ? 25.81406 0.71858   9.60563  1.000 28.95278  ? 34  THR A OG1  1 
ATOM   558  C CG2  . THR A 1 37  ? 24.71118 -0.90114  11.01328 1.000 31.03714  ? 34  THR A CG2  1 
ATOM   559  H H    . THR A 1 37  ? 28.54791 0.22390   10.72914 1.000 24.03165  ? 34  THR A H    1 
ATOM   560  H HA   . THR A 1 37  ? 26.35703 0.88705   12.17104 1.000 25.07899  ? 34  THR A HA   1 
ATOM   561  H HB   . THR A 1 37  ? 26.50821 -1.06949  10.07376 1.000 32.90965  ? 34  THR A HB   1 
ATOM   562  H HG1  . THR A 1 37  ? 25.45186 0.42726   8.90596  1.000 34.69879  ? 34  THR A HG1  1 
ATOM   563  H HG21 . THR A 1 37  ? 24.19061 -1.23123  10.26433 1.000 37.20002  ? 34  THR A HG21 1 
ATOM   564  H HG22 . THR A 1 37  ? 24.86488 -1.62952  11.63518 1.000 37.20002  ? 34  THR A HG22 1 
ATOM   565  H HG23 . THR A 1 37  ? 24.20862 -0.20397  11.46303 1.000 37.20002  ? 34  THR A HG23 1 
ATOM   566  N N    . VAL A 1 38  ? 26.59253 -0.77374  13.91950 1.000 22.51433  ? 35  VAL A N    1 
ATOM   567  C CA   . VAL A 1 38  ? 26.60987 -1.85064  14.89453 1.000 19.33776  ? 35  VAL A CA   1 
ATOM   568  C C    . VAL A 1 38  ? 25.32650 -2.65754  14.73801 1.000 23.26021  ? 35  VAL A C    1 
ATOM   569  O O    . VAL A 1 38  ? 24.24521 -2.18996  15.07130 1.000 24.48900  ? 35  VAL A O    1 
ATOM   570  C CB   . VAL A 1 38  ? 26.77734 -1.30944  16.32459 1.000 24.13522  ? 35  VAL A CB   1 
ATOM   571  C CG1  . VAL A 1 38  ? 26.80992 -2.42221  17.33445 1.000 29.43788  ? 35  VAL A CG1  1 
ATOM   572  C CG2  . VAL A 1 38  ? 28.05374 -0.48738  16.43159 1.000 27.47797  ? 35  VAL A CG2  1 
ATOM   573  H H    . VAL A 1 38  ? 26.23200 -0.04708  14.20512 1.000 26.97264  ? 35  VAL A H    1 
ATOM   574  H HA   . VAL A 1 38  ? 27.35468 -2.44262  14.70555 1.000 23.16077  ? 35  VAL A HA   1 
ATOM   575  H HB   . VAL A 1 38  ? 26.01340 -0.74519  16.52188 1.000 28.91771  ? 35  VAL A HB   1 
ATOM   576  H HG11 . VAL A 1 38  ? 26.89139 -2.04049  18.22246 1.000 35.28090  ? 35  VAL A HG11 1 
ATOM   577  H HG12 . VAL A 1 38  ? 25.98801 -2.93304  17.26811 1.000 35.28090  ? 35  VAL A HG12 1 
ATOM   578  H HG13 . VAL A 1 38  ? 27.57092 -2.99449  17.14932 1.000 35.28090  ? 35  VAL A HG13 1 
ATOM   579  H HG21 . VAL A 1 38  ? 28.14575 -0.16399  17.34145 1.000 32.92901  ? 35  VAL A HG21 1 
ATOM   580  H HG22 . VAL A 1 38  ? 28.81091 -1.04844  16.20179 1.000 32.92901  ? 35  VAL A HG22 1 
ATOM   581  H HG23 . VAL A 1 38  ? 27.99909 0.26200   15.81812 1.000 32.92901  ? 35  VAL A HG23 1 
ATOM   582  N N    . ALA A 1 39  ? 25.43564 -3.88367  14.23147 1.000 21.87097  ? 36  ALA A N    1 
ATOM   583  C CA   . ALA A 1 39  ? 24.25237 -4.66561  13.89282 1.000 27.71517  ? 36  ALA A CA   1 
ATOM   584  C C    . ALA A 1 39  ? 24.09027 -5.80575  14.87646 1.000 27.67453  ? 36  ALA A C    1 
ATOM   585  O O    . ALA A 1 39  ? 25.03243 -6.55298  15.12205 1.000 26.50785  ? 36  ALA A O    1 
ATOM   586  C CB   . ALA A 1 39  ? 24.35768 -5.20449  12.47284 1.000 30.04054  ? 36  ALA A CB   1 
ATOM   587  H H    . ALA A 1 39  ? 26.18247 -4.28086  14.07626 1.000 26.20062  ? 36  ALA A H    1 
ATOM   588  H HA   . ALA A 1 39  ? 23.46379 -4.10428  13.95564 1.000 33.21366  ? 36  ALA A HA   1 
ATOM   589  H HB1  . ALA A 1 39  ? 23.54894 -5.69635  12.26093 1.000 36.00410  ? 36  ALA A HB1  1 
ATOM   590  H HB2  . ALA A 1 39  ? 24.46248 -4.46028  11.85960 1.000 36.00410  ? 36  ALA A HB2  1 
ATOM   591  H HB3  . ALA A 1 39  ? 25.12716 -5.79218  12.41435 1.000 36.00410  ? 36  ALA A HB3  1 
ATOM   592  N N    . GLY A 1 40  ? 22.89792 -5.93651  15.45054 1.000 22.50917  ? 37  GLY A N    1 
ATOM   593  C CA   . GLY A 1 40  ? 22.64518 -7.02378  16.37534 1.000 22.92393  ? 37  GLY A CA   1 
ATOM   594  C C    . GLY A 1 40  ? 22.33837 -8.31810  15.65267 1.000 31.41263  ? 37  GLY A C    1 
ATOM   595  O O    . GLY A 1 40  ? 21.44524 -8.36833  14.79859 1.000 29.13333  ? 37  GLY A O    1 
ATOM   596  H H    . GLY A 1 40  ? 22.22865 -5.41246  15.31993 1.000 26.96645  ? 37  GLY A H    1 
ATOM   597  H HA2  . GLY A 1 40  ? 23.42593 -7.16119  16.93432 1.000 27.46417  ? 37  GLY A HA2  1 
ATOM   598  H HA3  . GLY A 1 40  ? 21.88851 -6.79955  16.93933 1.000 27.46417  ? 37  GLY A HA3  1 
ATOM   599  N N    . LEU A 1 41  ? 23.04658 -9.38729  16.03858 1.000 24.32896  ? 38  LEU A N    1 
ATOM   600  C CA   . LEU A 1 41  ? 22.85962 -10.68364 15.38555 1.000 27.14818  ? 38  LEU A CA   1 
ATOM   601  C C    . LEU A 1 41  ? 21.40306 -11.12093 15.48316 1.000 33.68669  ? 38  LEU A C    1 
ATOM   602  O O    . LEU A 1 41  ? 20.81362 -11.59483 14.50360 1.000 36.50295  ? 38  LEU A O    1 
ATOM   603  C CB   . LEU A 1 41  ? 23.77824 -11.72593 16.02627 1.000 28.66888  ? 38  LEU A CB   1 
ATOM   604  C CG   . LEU A 1 41  ? 23.68335 -13.14102 15.44507 1.000 35.54960  ? 38  LEU A CG   1 
ATOM   605  C CD1  . LEU A 1 41  ? 24.07967 -13.14155 13.98065 1.000 43.69516  ? 38  LEU A CD1  1 
ATOM   606  C CD2  . LEU A 1 41  ? 24.57177 -14.08075 16.26041 1.000 34.20881  ? 38  LEU A CD2  1 
ATOM   607  H H    . LEU A 1 41  ? 23.63316 -9.38704  16.66749 1.000 29.15020  ? 38  LEU A H    1 
ATOM   608  H HA   . LEU A 1 41  ? 23.09864 -10.61212 14.44818 1.000 32.53327  ? 38  LEU A HA   1 
ATOM   609  H HB2  . LEU A 1 41  ? 24.69561 -11.43012 15.91750 1.000 34.35811  ? 38  LEU A HB2  1 
ATOM   610  H HB3  . LEU A 1 41  ? 23.55854 -11.78579 16.96916 1.000 34.35811  ? 38  LEU A HB3  1 
ATOM   611  H HG   . LEU A 1 41  ? 22.76927 -13.46185 15.49446 1.000 42.61497  ? 38  LEU A HG   1 
ATOM   612  H HD11 . LEU A 1 41  ? 24.03704 -14.04962 13.64227 1.000 52.38965  ? 38  LEU A HD11 1 
ATOM   613  H HD12 . LEU A 1 41  ? 23.46574 -12.57549 13.48713 1.000 52.38965  ? 38  LEU A HD12 1 
ATOM   614  H HD13 . LEU A 1 41  ? 24.98374 -12.79988 13.89803 1.000 52.38965  ? 38  LEU A HD13 1 
ATOM   615  H HD21 . LEU A 1 41  ? 24.50454 -14.97624 15.89370 1.000 41.00602  ? 38  LEU A HD21 1 
ATOM   616  H HD22 . LEU A 1 41  ? 25.48949 -13.77068 16.20994 1.000 41.00602  ? 38  LEU A HD22 1 
ATOM   617  H HD23 . LEU A 1 41  ? 24.27185 -14.07769 17.18288 1.000 41.00602  ? 38  LEU A HD23 1 
ATOM   618  N N    . ALA A 1 42  ? 20.79034 -10.91805 16.63956 1.000 32.68452  ? 39  ALA A N    1 
ATOM   619  C CA   . ALA A 1 42  ? 19.48592 -11.49272 16.91602 1.000 38.30684  ? 39  ALA A CA   1 
ATOM   620  C C    . ALA A 1 42  ? 18.33960 -10.52590 16.66082 1.000 37.51211  ? 39  ALA A C    1 
ATOM   621  O O    . ALA A 1 42  ? 17.17806 -10.92086 16.79181 1.000 45.43321  ? 39  ALA A O    1 
ATOM   622  C CB   . ALA A 1 42  ? 19.43824 -11.99530 18.35191 1.000 38.14134  ? 39  ALA A CB   1 
ATOM   623  H H    . ALA A 1 42  ? 21.11296 -10.44790 17.28336 1.000 39.17687  ? 39  ALA A H    1 
ATOM   624  H HA   . ALA A 1 42  ? 19.35079 -12.25430 16.33068 1.000 45.92366  ? 39  ALA A HA   1 
ATOM   625  H HB1  . ALA A 1 42  ? 18.56837 -12.39044 18.51947 1.000 45.72506  ? 39  ALA A HB1  1 
ATOM   626  H HB2  . ALA A 1 42  ? 20.13326 -12.66028 18.47698 1.000 45.72506  ? 39  ALA A HB2  1 
ATOM   627  H HB3  . ALA A 1 42  ? 19.58342 -11.24800 18.95304 1.000 45.72506  ? 39  ALA A HB3  1 
ATOM   628  N N    . GLY A 1 43  ? 18.61545 -9.30346  16.29618 1.000 36.76070  ? 40  GLY A N    1 
ATOM   629  C CA   . GLY A 1 43  ? 17.58837 -8.30627  16.11398 1.000 33.95071  ? 40  GLY A CA   1 
ATOM   630  C C    . GLY A 1 43  ? 18.08478 -6.96989  16.60361 1.000 37.01496  ? 40  GLY A C    1 
ATOM   631  O O    . GLY A 1 43  ? 19.27573 -6.76708  16.77971 1.000 32.52972  ? 40  GLY A O    1 
ATOM   632  H H    . GLY A 1 43  ? 19.41097 -9.01495  16.14289 1.000 44.06829  ? 40  GLY A H    1 
ATOM   633  H HA2  . GLY A 1 43  ? 17.35907 -8.23371  15.17427 1.000 40.69631  ? 40  GLY A HA2  1 
ATOM   634  H HA3  . GLY A 1 43  ? 16.79469 -8.55181  16.61466 1.000 40.69631  ? 40  GLY A HA3  1 
ATOM   635  N N    . LYS A 1 44  ? 17.16503 -6.05458  16.84250 1.000 34.13155  ? 41  LYS A N    1 
ATOM   636  C CA   . LYS A 1 44  ? 17.50129 -4.68629  17.22008 1.000 33.31124  ? 41  LYS A CA   1 
ATOM   637  C C    . LYS A 1 44  ? 17.50483 -4.45746  18.73090 1.000 30.17258  ? 41  LYS A C    1 
ATOM   638  O O    . LYS A 1 44  ? 17.88230 -3.36585  19.17685 1.000 36.72401  ? 41  LYS A O    1 
ATOM   639  C CB   . LYS A 1 44  ? 16.50769 -3.73478  16.51568 1.000 37.33156  ? 41  LYS A CB   1 
ATOM   640  C CG   . LYS A 1 44  ? 16.63135 -2.27231  16.82830 1.000 65.97294  ? 41  LYS A CG   1 
ATOM   641  C CD   . LYS A 1 44  ? 17.42579 -1.52411  15.75886 1.000 67.12049  ? 41  LYS A CD   1 
ATOM   642  C CE   . LYS A 1 44  ? 17.05542 -0.03927  15.72244 1.000 69.98144  ? 41  LYS A CE   1 
ATOM   643  N NZ   . LYS A 1 44  ? 15.59671 0.19014   15.49860 1.000 100.33628 ? 41  LYS A NZ   1 
ATOM   644  H H    . LYS A 1 44  ? 16.31884 -6.19981  16.79273 1.000 40.91331  ? 41  LYS A H    1 
ATOM   645  H HA   . LYS A 1 44  ? 18.39655 -4.46292  16.92091 1.000 39.92894  ? 41  LYS A HA   1 
ATOM   646  H HB2  . LYS A 1 44  ? 16.62894 -3.83041  15.55806 1.000 44.75332  ? 41  LYS A HB2  1 
ATOM   647  H HB3  . LYS A 1 44  ? 15.60911 -4.00211  16.76466 1.000 44.75332  ? 41  LYS A HB3  1 
ATOM   648  H HG2  . LYS A 1 44  ? 15.74554 -1.88009  16.87735 1.000 79.12298  ? 41  LYS A HG2  1 
ATOM   649  H HG3  . LYS A 1 44  ? 17.08932 -2.16455  17.67657 1.000 79.12298  ? 41  LYS A HG3  1 
ATOM   650  H HD2  . LYS A 1 44  ? 18.37348 -1.59743  15.95227 1.000 80.50003  ? 41  LYS A HD2  1 
ATOM   651  H HD3  . LYS A 1 44  ? 17.23410 -1.90772  14.88880 1.000 80.50003  ? 41  LYS A HD3  1 
ATOM   652  H HE2  . LYS A 1 44  ? 17.29558 0.36702   16.56988 1.000 83.93318  ? 41  LYS A HE2  1 
ATOM   653  H HE3  . LYS A 1 44  ? 17.54005 0.38948   14.99980 1.000 83.93318  ? 41  LYS A HE3  1 
ATOM   654  H HZ1  . LYS A 1 44  ? 15.42972 1.06300   15.45037 1.000 120.35899 ? 41  LYS A HZ1  1 
ATOM   655  H HZ2  . LYS A 1 44  ? 15.34112 -0.19528  14.73819 1.000 120.35899 ? 41  LYS A HZ2  1 
ATOM   656  H HZ3  . LYS A 1 44  ? 15.12737 -0.15703  16.17038 1.000 120.35899 ? 41  LYS A HZ3  1 
ATOM   657  N N    . ASP A 1 45  ? 17.15312 -5.46134  19.51782 1.000 30.28533  ? 42  ASP A N    1 
ATOM   658  C CA   . ASP A 1 45  ? 17.07945 -5.34830  20.95101 1.000 28.92963  ? 42  ASP A CA   1 
ATOM   659  C C    . ASP A 1 45  ? 18.47368 -5.17879  21.58729 1.000 27.88742  ? 42  ASP A C    1 
ATOM   660  O O    . ASP A 1 45  ? 19.49456 -5.57698  21.01391 1.000 28.44838  ? 42  ASP A O    1 
ATOM   661  C CB   . ASP A 1 45  ? 16.42376 -6.58202  21.53739 1.000 36.75026  ? 42  ASP A CB   1 
ATOM   662  C CG   . ASP A 1 45  ? 14.95710 -6.74096  21.10625 1.000 68.25951  ? 42  ASP A CG   1 
ATOM   663  O OD1  . ASP A 1 45  ? 14.27744 -5.71208  20.85816 1.000 51.73974  ? 42  ASP A OD1  1 
ATOM   664  O OD2  . ASP A 1 45  ? 14.50118 -7.89178  21.03144 1.000 64.97618  ? 42  ASP A OD2  1 
ATOM   665  H H    . ASP A 1 45  ? 16.94571 -6.24491  19.23040 1.000 36.29784  ? 42  ASP A H    1 
ATOM   666  H HA   . ASP A 1 45  ? 16.55308 -4.56263  21.16680 1.000 34.67101  ? 42  ASP A HA   1 
ATOM   667  H HB2  . ASP A 1 45  ? 16.90950 -7.36810  21.24236 1.000 44.05576  ? 42  ASP A HB2  1 
ATOM   668  H HB3  . ASP A 1 45  ? 16.44655 -6.52181  22.50525 1.000 44.05576  ? 42  ASP A HB3  1 
ATOM   669  N N    . PRO A 1 46  ? 18.52707 -4.62821  22.79810 1.000 26.97715  ? 43  PRO A N    1 
ATOM   670  C CA   . PRO A 1 46  ? 19.82535 -4.45540  23.47380 1.000 24.80459  ? 43  PRO A CA   1 
ATOM   671  C C    . PRO A 1 46  ? 20.51399 -5.79713  23.69690 1.000 28.54683  ? 43  PRO A C    1 
ATOM   672  O O    . PRO A 1 46  ? 19.88116 -6.82680  23.99999 1.000 27.76449  ? 43  PRO A O    1 
ATOM   673  C CB   . PRO A 1 46  ? 19.43745 -3.80417  24.80917 1.000 26.13902  ? 43  PRO A CB   1 
ATOM   674  C CG   . PRO A 1 46  ? 18.14031 -3.09183  24.53525 1.000 33.63808  ? 43  PRO A CG   1 
ATOM   675  C CD   . PRO A 1 46  ? 17.41601 -4.07559  23.61244 1.000 29.25073  ? 43  PRO A CD   1 
ATOM   676  H HA   . PRO A 1 46  ? 20.40666 -3.86520  22.96918 1.000 29.72096  ? 43  PRO A HA   1 
ATOM   677  H HB2  . PRO A 1 46  ? 19.32135 -4.48739  25.48787 1.000 31.32227  ? 43  PRO A HB2  1 
ATOM   678  H HB3  . PRO A 1 46  ? 20.12586 -3.17808  25.08304 1.000 31.32227  ? 43  PRO A HB3  1 
ATOM   679  H HG2  . PRO A 1 46  ? 17.64900 -2.94837  25.35922 1.000 40.32115  ? 43  PRO A HG2  1 
ATOM   680  H HG3  . PRO A 1 46  ? 18.30328 -2.24342  24.09416 1.000 40.32115  ? 43  PRO A HG3  1 
ATOM   681  H HD2  . PRO A 1 46  ? 16.97754 -4.77403  24.12316 1.000 35.05633  ? 43  PRO A HD2  1 
ATOM   682  H HD3  . PRO A 1 46  ? 16.76901 -3.61727  23.05366 1.000 35.05633  ? 43  PRO A HD3  1 
ATOM   683  N N    . VAL A 1 47  ? 21.84601 -5.76311  23.60287 1.000 24.41420  ? 44  VAL A N    1 
ATOM   684  C CA   . VAL A 1 47  ? 22.68311 -6.94893  23.70686 1.000 20.54077  ? 44  VAL A CA   1 
ATOM   685  C C    . VAL A 1 47  ? 23.45885 -6.92241  25.00185 1.000 24.07862  ? 44  VAL A C    1 
ATOM   686  O O    . VAL A 1 47  ? 24.18552 -5.96984  25.27279 1.000 23.79535  ? 44  VAL A O    1 
ATOM   687  C CB   . VAL A 1 47  ? 23.66232 -7.03971  22.52450 1.000 26.78833  ? 44  VAL A CB   1 
ATOM   688  C CG1  . VAL A 1 47  ? 24.50629 -8.30519  22.62080 1.000 30.76548  ? 44  VAL A CG1  1 
ATOM   689  C CG2  . VAL A 1 47  ? 22.91510 -7.00044  21.22640 1.000 29.27217  ? 44  VAL A CG2  1 
ATOM   690  H H    . VAL A 1 47  ? 22.29510 -5.04089  23.47514 1.000 29.25248  ? 44  VAL A H    1 
ATOM   691  H HA   . VAL A 1 47  ? 22.10094 -7.72470  23.71971 1.000 24.60437  ? 44  VAL A HA   1 
ATOM   692  H HB   . VAL A 1 47  ? 24.26193 -6.27782  22.55428 1.000 32.10144  ? 44  VAL A HB   1 
ATOM   693  H HG11 . VAL A 1 47  ? 25.12058 -8.33295  21.87062 1.000 36.87402  ? 44  VAL A HG11 1 
ATOM   694  H HG12 . VAL A 1 47  ? 25.00239 -8.29126  23.45422 1.000 36.87402  ? 44  VAL A HG12 1 
ATOM   695  H HG13 . VAL A 1 47  ? 23.92051 -9.07799  22.59743 1.000 36.87402  ? 44  VAL A HG13 1 
ATOM   696  H HG21 . VAL A 1 47  ? 23.54859 -7.06999  20.49513 1.000 35.08206  ? 44  VAL A HG21 1 
ATOM   697  H HG22 . VAL A 1 47  ? 22.29333 -7.74438  21.19728 1.000 35.08206  ? 44  VAL A HG22 1 
ATOM   698  H HG23 . VAL A 1 47  ? 22.43090 -6.16211  21.16597 1.000 35.08206  ? 44  VAL A HG23 1 
ATOM   699  N N    . GLN A 1 48  ? 23.34066 -7.99420  25.76966 1.000 21.35675  ? 45  GLN A N    1 
ATOM   700  C CA   . GLN A 1 48  ? 24.09026 -8.16911  26.99168 1.000 22.51550  ? 45  GLN A CA   1 
ATOM   701  C C    . GLN A 1 48  ? 25.44443 -8.77410  26.66355 1.000 26.93317  ? 45  GLN A C    1 
ATOM   702  O O    . GLN A 1 48  ? 25.52328 -9.93269  26.22793 1.000 25.24061  ? 45  GLN A O    1 
ATOM   703  C CB   . GLN A 1 48  ? 23.32351 -9.08812  27.94355 1.000 28.57168  ? 45  GLN A CB   1 
ATOM   704  C CG   . GLN A 1 48  ? 23.98584 -9.31070  29.27535 1.000 32.56609  ? 45  GLN A CG   1 
ATOM   705  C CD   . GLN A 1 48  ? 23.17540 -10.28098 30.14876 1.000 54.72433  ? 45  GLN A CD   1 
ATOM   706  O OE1  . GLN A 1 48  ? 22.25804 -10.94348 29.65922 1.000 50.56393  ? 45  GLN A OE1  1 
ATOM   707  N NE2  . GLN A 1 48  ? 23.50511 -10.35329 31.41774 1.000 50.98484  ? 45  GLN A NE2  1 
ATOM   708  H H    . GLN A 1 48  ? 22.81504 -8.65200  25.59465 1.000 25.58355  ? 45  GLN A H    1 
ATOM   709  H HA   . GLN A 1 48  ? 24.22848 -7.30446  27.40902 1.000 26.97405  ? 45  GLN A HA   1 
ATOM   710  H HB2  . GLN A 1 48  ? 22.45187 -8.69765  28.11287 1.000 34.24147  ? 45  GLN A HB2  1 
ATOM   711  H HB3  . GLN A 1 48  ? 23.22217 -9.95471  27.51969 1.000 34.24147  ? 45  GLN A HB3  1 
ATOM   712  H HG2  . GLN A 1 48  ? 24.86825 -9.68873  29.13626 1.000 39.03476  ? 45  GLN A HG2  1 
ATOM   713  H HG3  . GLN A 1 48  ? 24.05755 -8.46448  29.74404 1.000 39.03476  ? 45  GLN A HG3  1 
ATOM   714  H HE21 . GLN A 1 48  ? 24.14804 -9.87061  31.72315 1.000 61.13726  ? 45  GLN A HE21 1 
ATOM   715  H HE22 . GLN A 1 48  ? 23.07813 -10.88333 31.94343 1.000 61.13726  ? 45  GLN A HE22 1 
ATOM   716  N N    . CYS A 1 49  ? 26.51491 -8.01428  26.90658 1.000 22.39252  ? 46  CYS A N    1 
ATOM   717  C CA   . CYS A 1 49  ? 27.84859 -8.48377  26.60220 1.000 23.36076  ? 46  CYS A CA   1 
ATOM   718  C C    . CYS A 1 49  ? 28.40442 -9.30898  27.76376 1.000 21.12051  ? 46  CYS A C    1 
ATOM   719  O O    . CYS A 1 49  ? 27.75833 -9.52201  28.79683 1.000 21.89455  ? 46  CYS A O    1 
ATOM   720  C CB   . CYS A 1 49  ? 28.75328 -7.30251  26.25481 1.000 24.05617  ? 46  CYS A CB   1 
ATOM   721  S SG   . CYS A 1 49  ? 28.23508 -6.41903  24.79626 1.000 24.74169  ? 46  CYS A SG   1 
ATOM   722  H H    . CYS A 1 49  ? 26.48567 -7.22515  27.24718 1.000 26.82648  ? 46  CYS A H    1 
ATOM   723  H HA   . CYS A 1 49  ? 27.80822 -9.06573  25.82722 1.000 27.98837  ? 46  CYS A HA   1 
ATOM   724  H HB2  . CYS A 1 49  ? 28.75200 -6.67824  26.99723 1.000 28.82285  ? 46  CYS A HB2  1 
ATOM   725  H HB3  . CYS A 1 49  ? 29.65242 -7.63176  26.09976 1.000 28.82285  ? 46  CYS A HB3  1 
ATOM   726  H HG   . CYS A 1 49  ? 29.02745 -5.54804  24.56494 1.000 29.64548  ? 46  CYS A HG   1 
ATOM   727  N N    . SER A 1 50  ? 29.66043 -9.74496  27.59905 1.000 18.55486  ? 47  SER A N    1 
ATOM   728  C CA   . SER A 1 50  ? 30.24173 -10.79016 28.43729 1.000 17.04064  ? 47  SER A CA   1 
ATOM   729  C C    . SER A 1 50  ? 30.38905 -10.35981 29.88449 1.000 23.21495  ? 47  SER A C    1 
ATOM   730  O O    . SER A 1 50  ? 30.31417 -11.20806 30.77445 1.000 21.59917  ? 47  SER A O    1 
ATOM   731  C CB   . SER A 1 50  ? 31.61661 -11.26390 27.92596 1.000 22.86588  ? 47  SER A CB   1 
ATOM   732  O OG   . SER A 1 50  ? 32.61619 -10.21704 27.90031 1.000 20.95332  ? 47  SER A OG   1 
ATOM   733  H H    . SER A 1 50  ? 30.20105 -9.44614  27.00069 1.000 22.22129  ? 47  SER A H    1 
ATOM   734  H HA   . SER A 1 50  ? 29.62986 -11.54083 28.38252 1.000 20.40421  ? 47  SER A HA   1 
ATOM   735  H HB2  . SER A 1 50  ? 31.93150 -11.97186 28.50951 1.000 27.39451  ? 47  SER A HB2  1 
ATOM   736  H HB3  . SER A 1 50  ? 31.50624 -11.60223 27.02360 1.000 27.39451  ? 47  SER A HB3  1 
ATOM   737  H HG   . SER A 1 50  ? 33.28478 -10.46897 27.45859 1.000 25.09944  ? 47  SER A HG   1 
ATOM   738  N N    . ARG A 1 51  ? 30.66050 -9.08126  30.12485 1.000 20.63999  ? 48  ARG A N    1 
ATOM   739  C CA   . ARG A 1 51  ? 30.80253 -8.53959  31.46750 1.000 19.55805  ? 48  ARG A CA   1 
ATOM   740  C C    . ARG A 1 51  ? 29.62451 -7.64956  31.82765 1.000 24.22180  ? 48  ARG A C    1 
ATOM   741  O O    . ARG A 1 51  ? 29.75774 -6.69099  32.60121 1.000 22.23325  ? 48  ARG A O    1 
ATOM   742  C CB   . ARG A 1 51  ? 32.13912 -7.79265  31.63185 1.000 18.79752  ? 48  ARG A CB   1 
ATOM   743  C CG   . ARG A 1 51  ? 33.28724 -8.69512  32.11012 1.000 19.78754  ? 48  ARG A CG   1 
ATOM   744  C CD   . ARG A 1 51  ? 33.73072 -9.63493  30.98063 1.000 21.64083  ? 48  ARG A CD   1 
ATOM   745  N NE   . ARG A 1 51  ? 34.71643 -10.62888 31.38275 1.000 20.33815  ? 48  ARG A NE   1 
ATOM   746  C CZ   . ARG A 1 51  ? 35.19960 -11.56862 30.56368 1.000 21.17099  ? 48  ARG A CZ   1 
ATOM   747  N NH1  . ARG A 1 51  ? 34.83522 -11.63724 29.29004 1.000 23.62020  ? 48  ARG A NH1  1 
ATOM   748  N NH2  . ARG A 1 51  ? 36.04976 -12.47465 31.03164 1.000 23.08696  ? 48  ARG A NH2  1 
ATOM   749  H H    . ARG A 1 51  ? 30.76955 -8.49292  29.50714 1.000 24.72344  ? 48  ARG A H    1 
ATOM   750  H HA   . ARG A 1 51  ? 30.82094 -9.27593  32.09866 1.000 23.42511  ? 48  ARG A HA   1 
ATOM   751  H HB2  . ARG A 1 51  ? 32.39422 -7.41491  30.77562 1.000 22.51248  ? 48  ARG A HB2  1 
ATOM   752  H HB3  . ARG A 1 51  ? 32.02434 -7.08527  32.28556 1.000 22.51248  ? 48  ARG A HB3  1 
ATOM   753  H HG2  . ARG A 1 51  ? 34.04383 -8.14814  32.37333 1.000 23.70049  ? 48  ARG A HG2  1 
ATOM   754  H HG3  . ARG A 1 51  ? 32.98881 -9.23194  32.86089 1.000 23.70049  ? 48  ARG A HG3  1 
ATOM   755  H HD2  . ARG A 1 51  ? 32.95307 -10.11033 30.64874 1.000 25.92444  ? 48  ARG A HD2  1 
ATOM   756  H HD3  . ARG A 1 51  ? 34.12281 -9.10344  30.27022 1.000 25.92444  ? 48  ARG A HD3  1 
ATOM   757  H HE   . ARG A 1 51  ? 35.00397 -10.61024 32.19304 1.000 24.36123  ? 48  ARG A HE   1 
ATOM   758  H HH11 . ARG A 1 51  ? 34.27448 -11.06804 28.97196 1.000 28.29969  ? 48  ARG A HH11 1 
ATOM   759  H HH12 . ARG A 1 51  ? 35.15972 -12.25092 28.78241 1.000 28.29969  ? 48  ARG A HH12 1 
ATOM   760  H HH21 . ARG A 1 51  ? 36.28712 -12.45521 31.85801 1.000 27.65980  ? 48  ARG A HH21 1 
ATOM   761  H HH22 . ARG A 1 51  ? 36.36311 -13.08097 30.50839 1.000 27.65980  ? 48  ARG A HH22 1 
ATOM   762  N N    . ASP A 1 52  ? 28.47853 -7.96412  31.24606 1.000 19.51475  ? 49  ASP A N    1 
ATOM   763  C CA   . ASP A 1 52  ? 27.15988 -7.43137  31.54718 1.000 21.82257  ? 49  ASP A CA   1 
ATOM   764  C C    . ASP A 1 52  ? 26.95259 -5.98155  31.14793 1.000 27.16366  ? 49  ASP A C    1 
ATOM   765  O O    . ASP A 1 52  ? 25.91707 -5.38267  31.52627 1.000 23.58455  ? 49  ASP A O    1 
ATOM   766  C CB   . ASP A 1 52  ? 26.82351 -7.60371  33.04155 1.000 23.42038  ? 49  ASP A CB   1 
ATOM   767  C CG   . ASP A 1 52  ? 26.35962 -9.01433  33.38403 1.000 31.89216  ? 49  ASP A CG   1 
ATOM   768  O OD1  . ASP A 1 52  ? 25.98188 -9.78010  32.47593 1.000 32.26614  ? 49  ASP A OD1  1 
ATOM   769  O OD2  . ASP A 1 52  ? 26.35378 -9.34687  34.57281 1.000 35.46332  ? 49  ASP A OD2  1 
ATOM   770  H H    . ASP A 1 52  ? 28.43650 -8.54197  30.61052 1.000 23.37315  ? 49  ASP A H    1 
ATOM   771  H HA   . ASP A 1 52  ? 26.52563 -7.93806  31.01625 1.000 26.14253  ? 49  ASP A HA   1 
ATOM   772  H HB2  . ASP A 1 52  ? 27.61572 -7.41273  33.56771 1.000 28.05991  ? 49  ASP A HB2  1 
ATOM   773  H HB3  . ASP A 1 52  ? 26.11186 -6.98849  33.27813 1.000 28.05991  ? 49  ASP A HB3  1 
ATOM   774  N N    . VAL A 1 53  ? 27.86455 -5.37566  30.38385 1.000 23.42357  ? 50  VAL A N    1 
ATOM   775  C CA   . VAL A 1 53  ? 27.53619 -4.11086  29.73927 1.000 20.49290  ? 50  VAL A CA   1 
ATOM   776  C C    . VAL A 1 53  ? 26.48176 -4.39241  28.66328 1.000 23.09620  ? 50  VAL A C    1 
ATOM   777  O O    . VAL A 1 53  ? 26.58741 -5.36285  27.87896 1.000 21.93574  ? 50  VAL A O    1 
ATOM   778  C CB   . VAL A 1 53  ? 28.81084 -3.48259  29.14367 1.000 19.88430  ? 50  VAL A CB   1 
ATOM   779  C CG1  . VAL A 1 53  ? 28.48126 -2.22766  28.33188 1.000 22.70171  ? 50  VAL A CG1  1 
ATOM   780  C CG2  . VAL A 1 53  ? 29.80717 -3.20049  30.28732 1.000 23.57944  ? 50  VAL A CG2  1 
ATOM   781  H H    . VAL A 1 53  ? 28.65742 -5.67069  30.22920 1.000 28.06374  ? 50  VAL A H    1 
ATOM   782  H HA   . VAL A 1 53  ? 27.17179 -3.48054  30.38022 1.000 24.54693  ? 50  VAL A HA   1 
ATOM   783  H HB   . VAL A 1 53  ? 29.22867 -4.09752  28.52064 1.000 23.81662  ? 50  VAL A HB   1 
ATOM   784  H HG11 . VAL A 1 53  ? 29.30046 -1.87263  27.95272 1.000 27.19751  ? 50  VAL A HG11 1 
ATOM   785  H HG12 . VAL A 1 53  ? 27.86350 -2.46377  27.62228 1.000 27.19751  ? 50  VAL A HG12 1 
ATOM   786  H HG13 . VAL A 1 53  ? 28.07580 -1.56976  28.91812 1.000 27.19751  ? 50  VAL A HG13 1 
ATOM   787  H HG21 . VAL A 1 53  ? 30.61252 -2.80844  29.91503 1.000 28.25078  ? 50  VAL A HG21 1 
ATOM   788  H HG22 . VAL A 1 53  ? 29.39977 -2.58467  30.91636 1.000 28.25078  ? 50  VAL A HG22 1 
ATOM   789  H HG23 . VAL A 1 53  ? 30.02105 -4.03514  30.73289 1.000 28.25078  ? 50  VAL A HG23 1 
ATOM   790  N N    . VAL A 1 54  ? 25.44767 -3.56765  28.63078 1.000 21.06753  ? 51  VAL A N    1 
ATOM   791  C CA   . VAL A 1 54  ? 24.33276 -3.72799  27.68861 1.000 22.42333  ? 51  VAL A CA   1 
ATOM   792  C C    . VAL A 1 54  ? 24.41360 -2.59872  26.66083 1.000 24.02671  ? 51  VAL A C    1 
ATOM   793  O O    . VAL A 1 54  ? 24.33930 -1.40752  26.99682 1.000 23.58838  ? 51  VAL A O    1 
ATOM   794  C CB   . VAL A 1 54  ? 22.96891 -3.73250  28.41193 1.000 23.90153  ? 51  VAL A CB   1 
ATOM   795  C CG1  . VAL A 1 54  ? 21.82380 -3.78183  27.40068 1.000 25.20204  ? 51  VAL A CG1  1 
ATOM   796  C CG2  . VAL A 1 54  ? 22.89182 -4.89304  29.39551 1.000 25.30034  ? 51  VAL A CG2  1 
ATOM   797  H H    . VAL A 1 54  ? 25.36045 -2.89025  29.15339 1.000 25.23648  ? 51  VAL A H    1 
ATOM   798  H HA   . VAL A 1 54  ? 24.42941 -4.57140  27.21932 1.000 26.86344  ? 51  VAL A HA   1 
ATOM   799  H HB   . VAL A 1 54  ? 22.87572 -2.91053  28.91847 1.000 28.63729  ? 51  VAL A HB   1 
ATOM   800  H HG11 . VAL A 1 54  ? 20.98056 -3.80702  27.87944 1.000 30.19790  ? 51  VAL A HG11 1 
ATOM   801  H HG12 . VAL A 1 54  ? 21.86273 -2.99076  26.84068 1.000 30.19790  ? 51  VAL A HG12 1 
ATOM   802  H HG13 . VAL A 1 54  ? 21.91836 -4.57828  26.85513 1.000 30.19790  ? 51  VAL A HG13 1 
ATOM   803  H HG21 . VAL A 1 54  ? 22.03356 -4.86805  29.84681 1.000 30.31586  ? 51  VAL A HG21 1 
ATOM   804  H HG22 . VAL A 1 54  ? 22.98523 -5.72662  28.90835 1.000 30.31586  ? 51  VAL A HG22 1 
ATOM   805  H HG23 . VAL A 1 54  ? 23.60873 -4.80628  30.04314 1.000 30.31586  ? 51  VAL A HG23 1 
ATOM   806  N N    . ILE A 1 55  ? 24.56462 -2.96710  25.39401 1.000 20.29861  ? 52  ILE A N    1 
ATOM   807  C CA   . ILE A 1 55  ? 24.76119 -2.04111  24.29101 1.000 20.09955  ? 52  ILE A CA   1 
ATOM   808  C C    . ILE A 1 55  ? 23.55919 -2.14634  23.36795 1.000 27.00195  ? 52  ILE A C    1 
ATOM   809  O O    . ILE A 1 55  ? 23.13777 -3.25556  23.01501 1.000 25.33495  ? 52  ILE A O    1 
ATOM   810  C CB   . ILE A 1 55  ? 26.05675 -2.40430  23.53947 1.000 23.95386  ? 52  ILE A CB   1 
ATOM   811  C CG1  . ILE A 1 55  ? 27.28249 -2.15019  24.44303 1.000 27.25020  ? 52  ILE A CG1  1 
ATOM   812  C CG2  . ILE A 1 55  ? 26.17365 -1.61584  22.25557 1.000 26.73133  ? 52  ILE A CG2  1 
ATOM   813  C CD1  . ILE A 1 55  ? 28.58993 -2.60641  23.80890 1.000 28.36618  ? 52  ILE A CD1  1 
ATOM   814  H H    . ILE A 1 55  ? 24.55607 -3.78830  25.13876 1.000 24.31378  ? 52  ILE A H    1 
ATOM   815  H HA   . ILE A 1 55  ? 24.81856 -1.12818  24.61376 1.000 24.07491  ? 52  ILE A HA   1 
ATOM   816  H HB   . ILE A 1 55  ? 26.02321 -3.34700  23.31340 1.000 28.70009  ? 52  ILE A HB   1 
ATOM   817  H HG12 . ILE A 1 55  ? 27.35134 -1.19913  24.62091 1.000 32.65569  ? 52  ILE A HG12 1 
ATOM   818  H HG13 . ILE A 1 55  ? 27.16718 -2.63577  25.27478 1.000 32.65569  ? 52  ILE A HG13 1 
ATOM   819  H HG21 . ILE A 1 55  ? 27.00226 -1.85571  21.81199 1.000 32.03304  ? 52  ILE A HG21 1 
ATOM   820  H HG22 . ILE A 1 55  ? 25.41907 -1.82870  21.68443 1.000 32.03304  ? 52  ILE A HG22 1 
ATOM   821  H HG23 . ILE A 1 55  ? 26.17290 -0.66880  22.46538 1.000 32.03304  ? 52  ILE A HG23 1 
ATOM   822  H HD11 . ILE A 1 55  ? 29.31238 -2.46967  24.44156 1.000 33.99487  ? 52  ILE A HD11 1 
ATOM   823  H HD12 . ILE A 1 55  ? 28.52053 -3.54752  23.58440 1.000 33.99487  ? 52  ILE A HD12 1 
ATOM   824  H HD13 . ILE A 1 55  ? 28.75017 -2.08583  23.00626 1.000 33.99487  ? 52  ILE A HD13 1 
ATOM   825  N N    . CYS A 1 56  ? 23.04007 -0.99171  22.93759 1.000 23.13783  ? 53  CYS A N    1 
ATOM   826  C CA   . CYS A 1 56  ? 21.91937 -0.96896  21.97784 1.000 23.90503  ? 53  CYS A CA   1 
ATOM   827  C C    . CYS A 1 56  ? 22.44974 -0.91636  20.55716 1.000 25.50145  ? 53  CYS A C    1 
ATOM   828  O O    . CYS A 1 56  ? 23.10720 0.07098   20.19433 1.000 25.13272  ? 53  CYS A O    1 
ATOM   829  C CB   . CYS A 1 56  ? 21.04481 0.25110   22.21530 1.000 23.41568  ? 53  CYS A CB   1 
ATOM   830  S SG   . CYS A 1 56  ? 20.23677 0.21686   23.77667 1.000 35.64351  ? 53  CYS A SG   1 
ATOM   831  H H    . CYS A 1 56  ? 23.31335 -0.21358  23.18136 1.000 27.72085  ? 53  CYS A H    1 
ATOM   832  H HA   . CYS A 1 56  ? 21.39188 -1.77563  22.08716 1.000 28.64149  ? 53  CYS A HA   1 
ATOM   833  H HB2  . CYS A 1 56  ? 21.59795 1.04719   22.18084 1.000 28.05426  ? 53  CYS A HB2  1 
ATOM   834  H HB3  . CYS A 1 56  ? 20.36389 0.29013   21.52558 1.000 28.05426  ? 53  CYS A HB3  1 
ATOM   835  H HG   . CYS A 1 56  ? 19.52540 1.17879   23.86960 1.000 42.72766  ? 53  CYS A HG   1 
ATOM   836  N N    . PRO A 1 57  ? 22.14609 -1.89091  19.70003 1.000 24.06842  ? 54  PRO A N    1 
ATOM   837  C CA   . PRO A 1 57  ? 22.61873 -1.81337  18.31777 1.000 24.10591  ? 54  PRO A CA   1 
ATOM   838  C C    . PRO A 1 57  ? 21.91859 -0.74284  17.48821 1.000 23.04538  ? 54  PRO A C    1 
ATOM   839  O O    . PRO A 1 57  ? 20.81490 -0.28604  17.78526 1.000 25.45595  ? 54  PRO A O    1 
ATOM   840  C CB   . PRO A 1 57  ? 22.33581 -3.20461  17.76125 1.000 26.28957  ? 54  PRO A CB   1 
ATOM   841  C CG   . PRO A 1 57  ? 21.39273 -3.84609  18.64294 1.000 30.65866  ? 54  PRO A CG   1 
ATOM   842  C CD   . PRO A 1 57  ? 21.37674 -3.11439  19.98752 1.000 24.20415  ? 54  PRO A CD   1 
ATOM   843  H HA   . PRO A 1 57  ? 23.57173 -1.63258  18.31614 1.000 28.88254  ? 54  PRO A HA   1 
ATOM   844  H HB2  . PRO A 1 57  ? 21.96177 -3.12175  16.87012 1.000 31.50293  ? 54  PRO A HB2  1 
ATOM   845  H HB3  . PRO A 1 57  ? 23.16350 -3.70931  17.72804 1.000 31.50293  ? 54  PRO A HB3  1 
ATOM   846  H HG2  . PRO A 1 57  ? 20.51223 -3.81176  18.23742 1.000 36.74584  ? 54  PRO A HG2  1 
ATOM   847  H HG3  . PRO A 1 57  ? 21.66285 -4.76875  18.77189 1.000 36.74584  ? 54  PRO A HG3  1 
ATOM   848  H HD2  . PRO A 1 57  ? 20.46956 -2.89947  20.25536 1.000 29.00043  ? 54  PRO A HD2  1 
ATOM   849  H HD3  . PRO A 1 57  ? 21.80946 -3.64319  20.67601 1.000 29.00043  ? 54  PRO A HD3  1 
ATOM   850  N N    . ASP A 1 58  ? 22.57383 -0.38977  16.39821 1.000 21.47072  ? 55  ASP A N    1 
ATOM   851  C CA   . ASP A 1 58  ? 22.05521 0.60599   15.49187 1.000 22.49323  ? 55  ASP A CA   1 
ATOM   852  C C    . ASP A 1 58  ? 20.96913 0.03157   14.58600 1.000 35.00510  ? 55  ASP A C    1 
ATOM   853  O O    . ASP A 1 58  ? 20.13721 0.79143   14.07672 1.000 30.80307  ? 55  ASP A O    1 
ATOM   854  C CB   . ASP A 1 58  ? 23.13686 1.16481   14.57636 1.000 22.91917  ? 55  ASP A CB   1 
ATOM   855  C CG   . ASP A 1 58  ? 24.25726 1.87637   15.32091 1.000 26.81332  ? 55  ASP A CG   1 
ATOM   856  O OD1  . ASP A 1 58  ? 23.97754 2.68913   16.20494 1.000 27.09388  ? 55  ASP A OD1  1 
ATOM   857  O OD2  . ASP A 1 58  ? 25.41880 1.62266   14.99359 1.000 26.56502  ? 55  ASP A OD2  1 
ATOM   858  H H    . ASP A 1 58  ? 23.33193 -0.71830  16.15956 1.000 25.72031  ? 55  ASP A H    1 
ATOM   859  H HA   . ASP A 1 58  ? 21.71099 1.33241   16.03476 1.000 26.94733  ? 55  ASP A HA   1 
ATOM   860  H HB2  . ASP A 1 58  ? 23.53138 0.43370   14.07563 1.000 27.45845  ? 55  ASP A HB2  1 
ATOM   861  H HB3  . ASP A 1 58  ? 22.73283 1.80345   13.96825 1.000 27.45845  ? 55  ASP A HB3  1 
ATOM   862  N N    . ALA A 1 59  ? 20.97614 -1.28231  14.37616 1.000 24.23169  ? 56  ALA A N    1 
ATOM   863  C CA   . ALA A 1 59  ? 20.15344 -1.98284  13.37321 1.000 29.07942  ? 56  ALA A CA   1 
ATOM   864  C C    . ALA A 1 59  ? 20.20435 -3.47430  13.70295 1.000 34.56340  ? 56  ALA A C    1 
ATOM   865  O O    . ALA A 1 59  ? 21.12407 -3.94337  14.38675 1.000 28.31027  ? 56  ALA A O    1 
ATOM   866  C CB   . ALA A 1 59  ? 20.67423 -1.74190  11.96095 1.000 31.71958  ? 56  ALA A CB   1 
ATOM   867  H H    . ALA A 1 59  ? 21.47265 -1.82506  14.82170 1.000 29.03348  ? 56  ALA A H    1 
ATOM   868  H HA   . ALA A 1 59  ? 19.23526 -1.67349  13.41966 1.000 34.85075  ? 56  ALA A HA   1 
ATOM   869  H HB1  . ALA A 1 59  ? 20.11176 -2.21934  11.33120 1.000 38.01894  ? 56  ALA A HB1  1 
ATOM   870  H HB2  . ALA A 1 59  ? 20.64803 -0.79070  11.77270 1.000 38.01894  ? 56  ALA A HB2  1 
ATOM   871  H HB3  . ALA A 1 59  ? 21.58656 -2.06590  11.90124 1.000 38.01894  ? 56  ALA A HB3  1 
ATOM   872  N N    . SER A 1 60  ? 19.22297 -4.22275  13.19652 1.000 29.18436  ? 57  SER A N    1 
ATOM   873  C CA   . SER A 1 60  ? 19.36779 -5.66965  13.17270 1.000 26.56594  ? 57  SER A CA   1 
ATOM   874  C C    . SER A 1 60  ? 20.29347 -6.05879  12.01781 1.000 24.41765  ? 57  SER A C    1 
ATOM   875  O O    . SER A 1 60  ? 20.47074 -5.31255  11.05650 1.000 30.63082  ? 57  SER A O    1 
ATOM   876  C CB   . SER A 1 60  ? 18.01402 -6.36039  12.99035 1.000 31.61161  ? 57  SER A CB   1 
ATOM   877  O OG   . SER A 1 60  ? 17.55121 -6.05487  11.69398 1.000 32.41220  ? 57  SER A OG   1 
ATOM   878  H H    . SER A 1 60  ? 18.48628 -3.92122  12.87099 1.000 34.97669  ? 57  SER A H    1 
ATOM   879  H HA   . SER A 1 60  ? 19.74116 -5.97384  14.01470 1.000 31.83458  ? 57  SER A HA   1 
ATOM   880  H HB2  . SER A 1 60  ? 18.11944 -7.32009  13.08402 1.000 37.88939  ? 57  SER A HB2  1 
ATOM   881  H HB3  . SER A 1 60  ? 17.38479 -6.02977  13.65039 1.000 37.88939  ? 57  SER A HB3  1 
ATOM   882  H HG   . SER A 1 60  ? 16.83499 -6.46598  11.54030 1.000 38.85009  ? 57  SER A HG   1 
ATOM   883  N N    . LEU A 1 61  ? 20.90372 -7.24905  12.12445 1.000 26.50385  ? 58  LEU A N    1 
ATOM   884  C CA   . LEU A 1 61  ? 21.75923 -7.72580  11.04036 1.000 27.52546  ? 58  LEU A CA   1 
ATOM   885  C C    . LEU A 1 61  ? 20.95677 -7.94470  9.75413  1.000 32.37513  ? 58  LEU A C    1 
ATOM   886  O O    . LEU A 1 61  ? 21.44888 -7.68709  8.65120  1.000 34.07005  ? 58  LEU A O    1 
ATOM   887  C CB   . LEU A 1 61  ? 22.44217 -9.02423  11.47273 1.000 28.26129  ? 58  LEU A CB   1 
ATOM   888  C CG   . LEU A 1 61  ? 23.47128 -9.58100  10.46859 1.000 29.60761  ? 58  LEU A CG   1 
ATOM   889  C CD1  . LEU A 1 61  ? 24.61763 -8.63462  10.22435 1.000 31.34513  ? 58  LEU A CD1  1 
ATOM   890  C CD2  . LEU A 1 61  ? 23.99979 -10.91709 10.98713 1.000 34.15053  ? 58  LEU A CD2  1 
ATOM   891  H H    . LEU A 1 61  ? 20.83801 -7.78144  12.79664 1.000 31.76006  ? 58  LEU A H    1 
ATOM   892  H HA   . LEU A 1 61  ? 22.44147 -7.06188  10.85419 1.000 32.98600  ? 58  LEU A HA   1 
ATOM   893  H HB2  . LEU A 1 61  ? 22.90738 -8.86270  12.30842 1.000 33.86899  ? 58  LEU A HB2  1 
ATOM   894  H HB3  . LEU A 1 61  ? 21.76022 -9.70251  11.59838 1.000 33.86899  ? 58  LEU A HB3  1 
ATOM   895  H HG   . LEU A 1 61  ? 23.02857 -9.70206  9.61404  1.000 35.48459  ? 58  LEU A HG   1 
ATOM   896  H HD11 . LEU A 1 61  ? 25.25656 -9.05909  9.63063  1.000 37.56960  ? 58  LEU A HD11 1 
ATOM   897  H HD12 . LEU A 1 61  ? 24.27602 -7.82325  9.81707  1.000 37.56960  ? 58  LEU A HD12 1 
ATOM   898  H HD13 . LEU A 1 61  ? 25.04125 -8.42635  11.07174 1.000 37.56960  ? 58  LEU A HD13 1 
ATOM   899  H HD21 . LEU A 1 61  ? 24.64405 -11.26930 10.35327 1.000 40.93608  ? 58  LEU A HD21 1 
ATOM   900  H HD22 . LEU A 1 61  ? 24.42525 -10.77599 11.84735 1.000 40.93608  ? 58  LEU A HD22 1 
ATOM   901  H HD23 . LEU A 1 61  ? 23.25787 -11.53465 11.08239 1.000 40.93608  ? 58  LEU A HD23 1 
ATOM   902  N N    . GLU A 1 62  ? 19.70450 -8.39584  9.88276  1.000 33.49318  ? 59  GLU A N    1 
ATOM   903  C CA   . GLU A 1 62  ? 18.88434 -8.58573  8.68717  1.000 38.01943  ? 59  GLU A CA   1 
ATOM   904  C C    . GLU A 1 62  ? 18.72171 -7.27446  7.91982  1.000 31.73194  ? 59  GLU A C    1 
ATOM   905  O O    . GLU A 1 62  ? 18.86117 -7.24295  6.70184  1.000 39.50467  ? 59  GLU A O    1 
ATOM   906  C CB   . GLU A 1 62  ? 17.54007 -9.15762  9.08793  1.000 42.95954  ? 59  GLU A CB   1 
ATOM   907  C CG   . GLU A 1 62  ? 16.76636 -9.69345  7.93228  1.000 72.90424  ? 59  GLU A CG   1 
ATOM   908  C CD   . GLU A 1 62  ? 15.31585 -9.84035  8.27440  1.000 102.62292 ? 59  GLU A CD   1 
ATOM   909  O OE1  . GLU A 1 62  ? 14.99296 -9.88277  9.48395  1.000 87.20321  ? 59  GLU A OE1  1 
ATOM   910  O OE2  . GLU A 1 62  ? 14.50286 -9.90725  7.33226  1.000 125.03457 ? 59  GLU A OE2  1 
ATOM   911  H H    . GLU A 1 62  ? 19.32008 -8.59242  10.62651 1.000 40.14726  ? 59  GLU A H    1 
ATOM   912  H HA   . GLU A 1 62  ? 19.31519 -9.21931  8.09233  1.000 45.57876  ? 59  GLU A HA   1 
ATOM   913  H HB2  . GLU A 1 62  ? 17.68150 -9.88345  9.71567  1.000 51.50690  ? 59  GLU A HB2  1 
ATOM   914  H HB3  . GLU A 1 62  ? 17.01176 -8.45808  9.50317  1.000 51.50690  ? 59  GLU A HB3  1 
ATOM   915  H HG2  . GLU A 1 62  ? 16.84425 -9.08375  7.18188  1.000 87.44053  ? 59  GLU A HG2  1 
ATOM   916  H HG3  . GLU A 1 62  ? 17.11382 -10.56566 7.68852  1.000 87.44053  ? 59  GLU A HG3  1 
ATOM   917  N N    . ASP A 1 63  ? 18.48674 -6.16284  8.61980  1.000 33.10396  ? 60  ASP A N    1 
ATOM   918  C CA   . ASP A 1 63  ? 18.35127 -4.89284  7.92003  1.000 31.77709  ? 60  ASP A CA   1 
ATOM   919  C C    . ASP A 1 63  ? 19.69594 -4.38221  7.42193  1.000 43.91086  ? 60  ASP A C    1 
ATOM   920  O O    . ASP A 1 63  ? 19.78616 -3.83187  6.32045  1.000 44.64519  ? 60  ASP A O    1 
ATOM   921  C CB   . ASP A 1 63  ? 17.70902 -3.83893  8.81078  1.000 34.46793  ? 60  ASP A CB   1 
ATOM   922  C CG   . ASP A 1 63  ? 16.25627 -4.13029  9.08858  1.000 41.41934  ? 60  ASP A CG   1 
ATOM   923  O OD1  . ASP A 1 63  ? 15.67425 -4.95216  8.35583  1.000 51.45786  ? 60  ASP A OD1  1 
ATOM   924  O OD2  . ASP A 1 63  ? 15.70415 -3.54098  10.02231 1.000 45.68711  ? 60  ASP A OD2  1 
ATOM   925  H H    . ASP A 1 63  ? 18.40443 -6.12113  9.47483  1.000 39.68020  ? 60  ASP A H    1 
ATOM   926  H HA   . ASP A 1 63  ? 17.76799 -5.04235  7.15955  1.000 38.08796  ? 60  ASP A HA   1 
ATOM   927  H HB2  . ASP A 1 63  ? 18.17858 -3.81114  9.65909  1.000 41.31697  ? 60  ASP A HB2  1 
ATOM   928  H HB3  . ASP A 1 63  ? 17.76492 -2.97556  8.37220  1.000 41.31697  ? 60  ASP A HB3  1 
ATOM   929  N N    . ALA A 1 64  ? 20.75735 -4.52190  8.22580  1.000 35.33138  ? 61  ALA A N    1 
ATOM   930  C CA   . ALA A 1 64  ? 22.03147 -3.97779  7.78771  1.000 27.89063  ? 61  ALA A CA   1 
ATOM   931  C C    . ALA A 1 64  ? 22.56707 -4.70851  6.57570  1.000 26.30420  ? 61  ALA A C    1 
ATOM   932  O O    . ALA A 1 64  ? 23.25925 -4.11835  5.75109  1.000 36.04171  ? 61  ALA A O    1 
ATOM   933  C CB   . ALA A 1 64  ? 23.07187 -4.05842  8.93124  1.000 31.92227  ? 61  ALA A CB   1 
ATOM   934  H H    . ALA A 1 64  ? 20.75932 -4.91059  8.99295  1.000 42.35311  ? 61  ALA A H    1 
ATOM   935  H HA   . ALA A 1 64  ? 21.89628 -3.04591  7.55483  1.000 33.42421  ? 61  ALA A HA   1 
ATOM   936  H HB1  . ALA A 1 64  ? 23.90855 -3.67526  8.62455  1.000 38.26217  ? 61  ALA A HB1  1 
ATOM   937  H HB2  . ALA A 1 64  ? 22.74060 -3.56094  9.69523  1.000 38.26217  ? 61  ALA A HB2  1 
ATOM   938  H HB3  . ALA A 1 64  ? 23.20315 -4.98839  9.17375  1.000 38.26217  ? 61  ALA A HB3  1 
ATOM   939  N N    . LYS A 1 65  ? 22.29852 -5.99413  6.48034  1.000 32.27922  ? 62  LYS A N    1 
ATOM   940  C CA   . LYS A 1 65  ? 22.75313 -6.77513  5.33493  1.000 36.01177  ? 62  LYS A CA   1 
ATOM   941  C C    . LYS A 1 65  ? 22.24711 -6.18579  4.03697  1.000 47.64345  ? 62  LYS A C    1 
ATOM   942  O O    . LYS A 1 65  ? 22.95637 -6.20651  3.02265  1.000 52.82927  ? 62  LYS A O    1 
ATOM   943  C CB   . LYS A 1 65  ? 22.26890 -8.21701  5.49539  1.000 46.79078  ? 62  LYS A CB   1 
ATOM   944  C CG   . LYS A 1 65  ? 22.65924 -9.19419  4.40516  1.000 67.19125  ? 62  LYS A CG   1 
ATOM   945  C CD   . LYS A 1 65  ? 21.75005 -10.43693 4.44830  1.000 79.47987  ? 62  LYS A CD   1 
ATOM   946  C CE   . LYS A 1 65  ? 21.55215 -10.98723 5.86448  1.000 74.56039  ? 62  LYS A CE   1 
ATOM   947  N NZ   . LYS A 1 65  ? 20.29195 -11.80212 5.98821  1.000 78.24031  ? 62  LYS A NZ   1 
ATOM   948  H H    . LYS A 1 65  ? 21.85465 -6.44604  7.06202  1.000 38.69051  ? 62  LYS A H    1 
ATOM   949  H HA   . LYS A 1 65  ? 23.72250 -6.77735  5.30013  1.000 43.16958  ? 62  LYS A HA   1 
ATOM   950  H HB2  . LYS A 1 65  ? 22.62784 -8.56308  6.32744  1.000 56.10438  ? 62  LYS A HB2  1 
ATOM   951  H HB3  . LYS A 1 65  ? 21.29964 -8.20561  5.53150  1.000 56.10438  ? 62  LYS A HB3  1 
ATOM   952  H HG2  . LYS A 1 65  ? 22.56300 -8.77013  3.53809  1.000 80.58495  ? 62  LYS A HG2  1 
ATOM   953  H HG3  . LYS A 1 65  ? 23.57763 -9.47780  4.53566  1.000 80.58495  ? 62  LYS A HG3  1 
ATOM   954  H HD2  . LYS A 1 65  ? 20.87775 -10.20182 4.09515  1.000 95.33129  ? 62  LYS A HD2  1 
ATOM   955  H HD3  . LYS A 1 65  ? 22.14839 -11.13789 3.90897  1.000 95.33129  ? 62  LYS A HD3  1 
ATOM   956  H HE2  . LYS A 1 65  ? 22.30355 -11.55668 6.09259  1.000 89.42792  ? 62  LYS A HE2  1 
ATOM   957  H HE3  . LYS A 1 65  ? 21.49547 -10.24688 6.48863  1.000 89.42792  ? 62  LYS A HE3  1 
ATOM   958  H HZ1  . LYS A 1 65  ? 20.19442 -12.08660 6.82586  1.000 93.84382  ? 62  LYS A HZ1  1 
ATOM   959  H HZ2  . LYS A 1 65  ? 19.58626 -11.30681 5.76738  1.000 93.84382  ? 62  LYS A HZ2  1 
ATOM   960  H HZ3  . LYS A 1 65  ? 20.33092 -12.50714 5.44643  1.000 93.84382  ? 62  LYS A HZ3  1 
ATOM   961  N N    . LYS A 1 66  ? 21.03621 -5.63256  4.05926  1.000 46.89687  ? 63  LYS A N    1 
ATOM   962  C CA   . LYS A 1 66  ? 20.45721 -5.04335  2.85969  1.000 64.95203  ? 63  LYS A CA   1 
ATOM   963  C C    . LYS A 1 66  ? 21.12781 -3.73265  2.46920  1.000 56.92140  ? 63  LYS A C    1 
ATOM   964  O O    . LYS A 1 66  ? 20.98840 -3.30722  1.32176  1.000 60.16232  ? 63  LYS A O    1 
ATOM   965  C CB   . LYS A 1 66  ? 18.94927 -4.80630  3.06068  1.000 60.92747  ? 63  LYS A CB   1 
ATOM   966  C CG   . LYS A 1 66  ? 18.10848 -6.04937  3.35011  1.000 56.48014  ? 63  LYS A CG   1 
ATOM   967  C CD   . LYS A 1 66  ? 16.70961 -5.66656  3.86905  1.000 72.61161  ? 63  LYS A CD   1 
ATOM   968  C CE   . LYS A 1 66  ? 15.93720 -6.88076  4.39018  1.000 76.62044  ? 63  LYS A CE   1 
ATOM   969  N NZ   . LYS A 1 66  ? 15.74566 -7.90453  3.32603  1.000 84.13094  ? 63  LYS A NZ   1 
ATOM   970  H H    . LYS A 1 66  ? 20.53233 -5.58642  4.75465  1.000 56.23170  ? 63  LYS A H    1 
ATOM   971  H HA   . LYS A 1 66  ? 20.57335 -5.66921  2.12778  1.000 77.89789  ? 63  LYS A HA   1 
ATOM   972  H HB2  . LYS A 1 66  ? 18.83480 -4.20194  3.81072  1.000 73.06841  ? 63  LYS A HB2  1 
ATOM   973  H HB3  . LYS A 1 66  ? 18.59553 -4.40288  2.25258  1.000 73.06841  ? 63  LYS A HB3  1 
ATOM   974  H HG2  . LYS A 1 66  ? 18.00235 -6.56399  2.53475  1.000 67.73162  ? 63  LYS A HG2  1 
ATOM   975  H HG3  . LYS A 1 66  ? 18.54954 -6.58676  4.02655  1.000 67.73162  ? 63  LYS A HG3  1 
ATOM   976  H HD2  . LYS A 1 66  ? 16.80189 -5.03177  4.59667  1.000 87.08938  ? 63  LYS A HD2  1 
ATOM   977  H HD3  . LYS A 1 66  ? 16.19842 -5.27048  3.14606  1.000 87.08938  ? 63  LYS A HD3  1 
ATOM   978  H HE2  . LYS A 1 66  ? 16.43180 -7.28727  5.11888  1.000 91.89998  ? 63  LYS A HE2  1 
ATOM   979  H HE3  . LYS A 1 66  ? 15.06328 -6.59628  4.70043  1.000 91.89998  ? 63  LYS A HE3  1 
ATOM   980  H HZ1  . LYS A 1 66  ? 15.28881 -8.59694  3.64846  1.000 100.91257 ? 63  LYS A HZ1  1 
ATOM   981  H HZ2  . LYS A 1 66  ? 15.29483 -7.55359  2.64361  1.000 100.91257 ? 63  LYS A HZ2  1 
ATOM   982  H HZ3  . LYS A 1 66  ? 16.53588 -8.19092  3.03339  1.000 100.91257 ? 63  LYS A HZ3  1 
ATOM   983  N N    . GLU A 1 67  ? 21.84193 -3.07393  3.37958  1.000 55.31499  ? 64  GLU A N    1 
ATOM   984  C CA   . GLU A 1 67  ? 22.49512 -1.80969  3.05640  1.000 41.85384  ? 64  GLU A CA   1 
ATOM   985  C C    . GLU A 1 67  ? 23.98049 -1.96995  2.75472  1.000 48.15517  ? 64  GLU A C    1 
ATOM   986  O O    . GLU A 1 67  ? 24.72336 -0.98045  2.76259  1.000 53.34664  ? 64  GLU A O    1 
ATOM   987  C CB   . GLU A 1 67  ? 22.29588 -0.79813  4.18638  1.000 43.40160  ? 64  GLU A CB   1 
ATOM   988  C CG   . GLU A 1 67  ? 20.83213 -0.47312  4.38701  1.000 70.64035  ? 64  GLU A CG   1 
ATOM   989  C CD   . GLU A 1 67  ? 20.62252 0.75432   5.22580  1.000 92.60865  ? 64  GLU A CD   1 
ATOM   990  O OE1  . GLU A 1 67  ? 20.84761 0.67214   6.44858  1.000 101.54616 ? 64  GLU A OE1  1 
ATOM   991  O OE2  . GLU A 1 67  ? 20.24080 1.80256   4.66049  1.000 103.62355 ? 64  GLU A OE2  1 
ATOM   992  H H    . GLU A 1 67  ? 21.96152 -3.33955  4.18874  1.000 66.33344  ? 64  GLU A H    1 
ATOM   993  H HA   . GLU A 1 67  ? 22.07111 -1.45475  2.25944  1.000 50.18006  ? 64  GLU A HA   1 
ATOM   994  H HB2  . GLU A 1 67  ? 22.64300 -1.16839  5.01301  1.000 52.03737  ? 64  GLU A HB2  1 
ATOM   995  H HB3  . GLU A 1 67  ? 22.76426 0.02276   3.96808  1.000 52.03737  ? 64  GLU A HB3  1 
ATOM   996  H HG2  . GLU A 1 67  ? 20.42043 -0.31994  3.52218  1.000 84.72387  ? 64  GLU A HG2  1 
ATOM   997  H HG3  . GLU A 1 67  ? 20.40045 -1.21881  4.83254  1.000 84.72387  ? 64  GLU A HG3  1 
ATOM   998  N N    . GLY A 1 68  ? 24.42481 -3.18112  2.47168  1.000 46.14553  ? 65  GLY A N    1 
ATOM   999  C CA   . GLY A 1 68  ? 25.78923 -3.39191  2.05082  1.000 53.28332  ? 65  GLY A CA   1 
ATOM   1000 C C    . GLY A 1 68  ? 26.07705 -2.72477  0.72051  1.000 64.50701  ? 65  GLY A C    1 
ATOM   1001 O O    . GLY A 1 68  ? 25.27676 -1.93634  0.21345  1.000 70.51466  ? 65  GLY A O    1 
ATOM   1002 H H    . GLY A 1 68  ? 23.95129 -3.89759  2.51684  1.000 55.33009  ? 65  GLY A H    1 
ATOM   1003 H HA2  . GLY A 1 68  ? 26.39306 -3.02618  2.71604  1.000 63.89543  ? 65  GLY A HA2  1 
ATOM   1004 H HA3  . GLY A 1 68  ? 25.95677 -4.34312  1.96121  1.000 63.89543  ? 65  GLY A HA3  1 
ATOM   1005 N N    . PRO A 1 69  ? 27.25711 -2.99632  0.14318  1.000 59.28504  ? 66  PRO A N    1 
ATOM   1006 C CA   . PRO A 1 69  ? 28.33561 -3.74440  0.79896  1.000 43.77167  ? 66  PRO A CA   1 
ATOM   1007 C C    . PRO A 1 69  ? 29.14754 -2.81547  1.67777  1.000 43.77257  ? 66  PRO A C    1 
ATOM   1008 O O    . PRO A 1 69  ? 29.05134 -1.59406  1.58432  1.000 39.83671  ? 66  PRO A O    1 
ATOM   1009 C CB   . PRO A 1 69  ? 29.17391 -4.26157  -0.36662 1.000 53.10672  ? 66  PRO A CB   1 
ATOM   1010 C CG   . PRO A 1 69  ? 29.06331 -3.15344  -1.38092 1.000 53.62511  ? 66  PRO A CG   1 
ATOM   1011 C CD   . PRO A 1 69  ? 27.67609 -2.50840  -1.18162 1.000 54.85483  ? 66  PRO A CD   1 
ATOM   1012 H HA   . PRO A 1 69  ? 28.00690 -4.50524  1.30291  1.000 52.48146  ? 66  PRO A HA   1 
ATOM   1013 H HB2  . PRO A 1 69  ? 30.09322 -4.39685  -0.08829 1.000 63.68351  ? 66  PRO A HB2  1 
ATOM   1014 H HB3  . PRO A 1 69  ? 28.80470 -5.09156  -0.70676 1.000 63.68351  ? 66  PRO A HB3  1 
ATOM   1015 H HG2  . PRO A 1 69  ? 29.76649 -2.50302  -1.22799 1.000 64.30559  ? 66  PRO A HG2  1 
ATOM   1016 H HG3  . PRO A 1 69  ? 29.14185 -3.52307  -2.27429 1.000 64.30559  ? 66  PRO A HG3  1 
ATOM   1017 H HD2  . PRO A 1 69  ? 27.74222 -1.54067  -1.18716 1.000 65.78125  ? 66  PRO A HD2  1 
ATOM   1018 H HD3  . PRO A 1 69  ? 27.05755 -2.80260  -1.86846 1.000 65.78125  ? 66  PRO A HD3  1 
ATOM   1019 N N    . TYR A 1 70  ? 29.95846 -3.43290  2.52684  1.000 29.21326  ? 67  TYR A N    1 
ATOM   1020 C CA   . TYR A 1 70  ? 30.78648 -2.75633  3.50592  1.000 26.65090  ? 67  TYR A CA   1 
ATOM   1021 C C    . TYR A 1 70  ? 32.24633 -2.93178  3.16339  1.000 24.60237  ? 67  TYR A C    1 
ATOM   1022 O O    . TYR A 1 70  ? 32.65809 -3.97807  2.66985  1.000 28.72793  ? 67  TYR A O    1 
ATOM   1023 C CB   . TYR A 1 70  ? 30.48418 -3.34616  4.90214  1.000 27.27573  ? 67  TYR A CB   1 
ATOM   1024 C CG   . TYR A 1 70  ? 29.08343 -3.09067  5.32580  1.000 31.84281  ? 67  TYR A CG   1 
ATOM   1025 C CD1  . TYR A 1 70  ? 28.75380 -1.93626  6.00483  1.000 27.85800  ? 67  TYR A CD1  1 
ATOM   1026 C CD2  . TYR A 1 70  ? 28.05605 -3.99935  5.03279  1.000 31.41212  ? 67  TYR A CD2  1 
ATOM   1027 C CE1  . TYR A 1 70  ? 27.47348 -1.67743  6.38854  1.000 30.32571  ? 67  TYR A CE1  1 
ATOM   1028 C CE2  . TYR A 1 70  ? 26.75996 -3.74762  5.43144  1.000 29.81943  ? 67  TYR A CE2  1 
ATOM   1029 C CZ   . TYR A 1 70  ? 26.47701 -2.57958  6.11147  1.000 32.57904  ? 67  TYR A CZ   1 
ATOM   1030 O OH   . TYR A 1 70  ? 25.22142 -2.25871  6.52906  1.000 33.30171  ? 67  TYR A OH   1 
ATOM   1031 H H    . TYR A 1 70  ? 30.04853 -4.28774  2.55370  1.000 35.01136  ? 67  TYR A H    1 
ATOM   1032 H HA   . TYR A 1 70  ? 30.61096 -1.80238  3.51450  1.000 31.93652  ? 67  TYR A HA   1 
ATOM   1033 H HB2  . TYR A 1 70  ? 30.62359 -4.30582  4.87914  1.000 32.68633  ? 67  TYR A HB2  1 
ATOM   1034 H HB3  . TYR A 1 70  ? 31.07678 -2.94037  5.55410  1.000 32.68633  ? 67  TYR A HB3  1 
ATOM   1035 H HD1  . TYR A 1 70  ? 29.42143 -1.32060  6.20515  1.000 33.38505  ? 67  TYR A HD1  1 
ATOM   1036 H HD2  . TYR A 1 70  ? 28.25068 -4.77928  4.56511  1.000 37.64999  ? 67  TYR A HD2  1 
ATOM   1037 H HE1  . TYR A 1 70  ? 27.27392 -0.88856  6.83883  1.000 36.34630  ? 67  TYR A HE1  1 
ATOM   1038 H HE2  . TYR A 1 70  ? 26.08375 -4.35802  5.24424  1.000 35.73877  ? 67  TYR A HE2  1 
ATOM   1039 H HH   . TYR A 1 70  ? 24.68872 -2.88068  6.34202  1.000 39.91751  ? 67  TYR A HH   1 
ATOM   1040 N N    . ASP A 1 71  ? 33.03025 -1.89598  3.43137  1.000 24.20605  ? 68  ASP A N    1 
ATOM   1041 C CA   . ASP A 1 71  ? 34.45180 -1.94593  3.18399  1.000 22.74520  ? 68  ASP A CA   1 
ATOM   1042 C C    . ASP A 1 71  ? 35.19189 -2.84491  4.18235  1.000 25.02379  ? 68  ASP A C    1 
ATOM   1043 O O    . ASP A 1 71  ? 36.27310 -3.34648  3.85988  1.000 25.93690  ? 68  ASP A O    1 
ATOM   1044 C CB   . ASP A 1 71  ? 35.01458 -0.53934  3.22573  1.000 25.72968  ? 68  ASP A CB   1 
ATOM   1045 C CG   . ASP A 1 71  ? 34.39005 0.35406   2.17028  1.000 33.62278  ? 68  ASP A CG   1 
ATOM   1046 O OD1  . ASP A 1 71  ? 34.76688 0.18600   1.00416  1.000 36.88688  ? 68  ASP A OD1  1 
ATOM   1047 O OD2  . ASP A 1 71  ? 33.50365 1.16717   2.48240  1.000 28.52217  ? 68  ASP A OD2  1 
ATOM   1048 H H    . ASP A 1 71  ? 32.75678 -1.14944  3.75923  1.000 29.00271  ? 68  ASP A H    1 
ATOM   1049 H HA   . ASP A 1 71  ? 34.60898 -2.31239  2.29974  1.000 27.24970  ? 68  ASP A HA   1 
ATOM   1050 H HB2  . ASP A 1 71  ? 34.83662 -0.15022  4.09625  1.000 30.83106  ? 68  ASP A HB2  1 
ATOM   1051 H HB3  . ASP A 1 71  ? 35.97086 -0.57349  3.06681  1.000 30.83106  ? 68  ASP A HB3  1 
ATOM   1052 N N    . VAL A 1 72  ? 34.61600 -3.06573  5.35024  1.000 24.39008  ? 69  VAL A N    1 
ATOM   1053 C CA   . VAL A 1 72  ? 35.16722 -3.97609  6.35560  1.000 22.47546  ? 69  VAL A CA   1 
ATOM   1054 C C    . VAL A 1 72  ? 34.02039 -4.58268  7.14841  1.000 24.13205  ? 69  VAL A C    1 
ATOM   1055 O O    . VAL A 1 72  ? 33.04264 -3.90739  7.47921  1.000 22.49670  ? 69  VAL A O    1 
ATOM   1056 C CB   . VAL A 1 72  ? 36.19444 -3.25419  7.27330  1.000 22.81992  ? 69  VAL A CB   1 
ATOM   1057 C CG1  . VAL A 1 72  ? 35.56477 -2.19006  8.14772  1.000 28.06554  ? 69  VAL A CG1  1 
ATOM   1058 C CG2  . VAL A 1 72  ? 36.93692 -4.24701  8.12160  1.000 23.33023  ? 69  VAL A CG2  1 
ATOM   1059 H H    . VAL A 1 72  ? 33.88225 -2.69196  5.59824  1.000 29.22354  ? 69  VAL A H    1 
ATOM   1060 H HA   . VAL A 1 72  ? 35.62765 -4.70328  5.90827  1.000 26.92600  ? 69  VAL A HA   1 
ATOM   1061 H HB   . VAL A 1 72  ? 36.82066 -2.79979  6.68826  1.000 27.33935  ? 69  VAL A HB   1 
ATOM   1062 H HG11 . VAL A 1 72  ? 36.25306 -1.78686  8.69962  1.000 33.63409  ? 69  VAL A HG11 1 
ATOM   1063 H HG12 . VAL A 1 72  ? 35.15790 -1.51591  7.58125  1.000 33.63409  ? 69  VAL A HG12 1 
ATOM   1064 H HG13 . VAL A 1 72  ? 34.88944 -2.60170  8.70930  1.000 33.63409  ? 69  VAL A HG13 1 
ATOM   1065 H HG21 . VAL A 1 72  ? 37.58142 -3.77369  8.67068  1.000 27.95173  ? 69  VAL A HG21 1 
ATOM   1066 H HG22 . VAL A 1 72  ? 36.30305 -4.71658  8.68606  1.000 27.95173  ? 69  VAL A HG22 1 
ATOM   1067 H HG23 . VAL A 1 72  ? 37.39456 -4.87691  7.54308  1.000 27.95173  ? 69  VAL A HG23 1 
ATOM   1068 N N    . VAL A 1 73  ? 34.15295 -5.87764  7.46138  1.000 20.13249  ? 70  VAL A N    1 
ATOM   1069 C CA   . VAL A 1 73  ? 33.26359 -6.56783  8.35620  1.000 20.55861  ? 70  VAL A CA   1 
ATOM   1070 C C    . VAL A 1 73  ? 34.09079 -6.92866  9.57448  1.000 22.71598  ? 70  VAL A C    1 
ATOM   1071 O O    . VAL A 1 73  ? 35.17538 -7.51680  9.42473  1.000 22.47523  ? 70  VAL A O    1 
ATOM   1072 C CB   . VAL A 1 73  ? 32.66206 -7.83003  7.74581  1.000 24.22564  ? 70  VAL A CB   1 
ATOM   1073 C CG1  . VAL A 1 73  ? 31.84158 -8.52817  8.78653  1.000 26.33959  ? 70  VAL A CG1  1 
ATOM   1074 C CG2  . VAL A 1 73  ? 31.78949 -7.47153  6.52308  1.000 25.79648  ? 70  VAL A CG2  1 
ATOM   1075 H H    . VAL A 1 73  ? 34.77676 -6.38042  7.14885  1.000 24.11443  ? 70  VAL A H    1 
ATOM   1076 H HA   . VAL A 1 73  ? 32.52692 -5.98242  8.59182  1.000 24.62578  ? 70  VAL A HA   1 
ATOM   1077 H HB   . VAL A 1 73  ? 33.36896 -8.42161  7.44375  1.000 29.02621  ? 70  VAL A HB   1 
ATOM   1078 H HG11 . VAL A 1 73  ? 31.43914 -9.31847  8.39363  1.000 31.56296  ? 70  VAL A HG11 1 
ATOM   1079 H HG12 . VAL A 1 73  ? 32.41745 -8.78234  9.52456  1.000 31.56296  ? 70  VAL A HG12 1 
ATOM   1080 H HG13 . VAL A 1 73  ? 31.14922 -7.92528  9.09966  1.000 31.56296  ? 70  VAL A HG13 1 
ATOM   1081 H HG21 . VAL A 1 73  ? 31.44540 -8.28889  6.13013  1.000 30.91122  ? 70  VAL A HG21 1 
ATOM   1082 H HG22 . VAL A 1 73  ? 31.05445 -6.90923  6.81363  1.000 30.91122  ? 70  VAL A HG22 1 
ATOM   1083 H HG23 . VAL A 1 73  ? 32.33334 -6.99654  5.87538  1.000 30.91122  ? 70  VAL A HG23 1 
ATOM   1084 N N    . VAL A 1 74  ? 33.59199 -6.56344  10.76228 1.000 19.51962  ? 71  VAL A N    1 
ATOM   1085 C CA   . VAL A 1 74  ? 34.37132 -6.66072  11.99043 1.000 19.77058  ? 71  VAL A CA   1 
ATOM   1086 C C    . VAL A 1 74  ? 33.68830 -7.66630  12.91285 1.000 21.72007  ? 71  VAL A C    1 
ATOM   1087 O O    . VAL A 1 74  ? 32.50341 -7.52613  13.24394 1.000 22.88131  ? 71  VAL A O    1 
ATOM   1088 C CB   . VAL A 1 74  ? 34.50978 -5.29806  12.69550 1.000 20.79200  ? 71  VAL A CB   1 
ATOM   1089 C CG1  . VAL A 1 74  ? 35.31984 -5.51133  14.00249 1.000 27.62752  ? 71  VAL A CG1  1 
ATOM   1090 C CG2  . VAL A 1 74  ? 35.19502 -4.28501  11.83814 1.000 23.85969  ? 71  VAL A CG2  1 
ATOM   1091 H H    . VAL A 1 74  ? 32.79748 -6.25460  10.87622 1.000 23.37900  ? 71  VAL A H    1 
ATOM   1092 H HA   . VAL A 1 74  ? 35.25909 -6.98607  11.77384 1.000 23.68014  ? 71  VAL A HA   1 
ATOM   1093 H HB   . VAL A 1 74  ? 33.62479 -4.95034  12.88730 1.000 24.90585  ? 71  VAL A HB   1 
ATOM   1094 H HG11 . VAL A 1 74  ? 35.42060 -4.65889  14.45424 1.000 33.10848  ? 71  VAL A HG11 1 
ATOM   1095 H HG12 . VAL A 1 74  ? 34.84136 -6.13332  14.57265 1.000 33.10848  ? 71  VAL A HG12 1 
ATOM   1096 H HG13 . VAL A 1 74  ? 36.19194 -5.87196  13.77821 1.000 33.10848  ? 71  VAL A HG13 1 
ATOM   1097 H HG21 . VAL A 1 74  ? 35.22810 -3.43986  12.31304 1.000 28.58708  ? 71  VAL A HG21 1 
ATOM   1098 H HG22 . VAL A 1 74  ? 36.09489 -4.59143  11.64515 1.000 28.58708  ? 71  VAL A HG22 1 
ATOM   1099 H HG23 . VAL A 1 74  ? 34.69673 -4.18118  11.01242 1.000 28.58708  ? 71  VAL A HG23 1 
ATOM   1100 N N    . LEU A 1 75  ? 34.45095 -8.64020  13.37960 1.000 21.02322  ? 72  LEU A N    1 
ATOM   1101 C CA   . LEU A 1 75  ? 33.96798 -9.65466  14.30752 1.000 19.38258  ? 72  LEU A CA   1 
ATOM   1102 C C    . LEU A 1 75  ? 34.65753 -9.49057  15.66039 1.000 21.96299  ? 72  LEU A C    1 
ATOM   1103 O O    . LEU A 1 75  ? 35.86108 -9.78240  15.78218 1.000 20.90189  ? 72  LEU A O    1 
ATOM   1104 C CB   . LEU A 1 75  ? 34.22814 -11.06980 13.77516 1.000 22.86997  ? 72  LEU A CB   1 
ATOM   1105 C CG   . LEU A 1 75  ? 33.69054 -11.43249 12.39384 1.000 26.62980  ? 72  LEU A CG   1 
ATOM   1106 C CD1  . LEU A 1 75  ? 34.08422 -12.87010 12.11999 1.000 33.39598  ? 72  LEU A CD1  1 
ATOM   1107 C CD2  . LEU A 1 75  ? 32.20777 -11.28254 12.36631 1.000 26.66944  ? 72  LEU A CD2  1 
ATOM   1108 H H    . LEU A 1 75  ? 35.27863 -8.74086  13.16888 1.000 25.18331  ? 72  LEU A H    1 
ATOM   1109 H HA   . LEU A 1 75  ? 33.01183 -9.53272  14.41619 1.000 23.21454  ? 72  LEU A HA   1 
ATOM   1110 H HB2  . LEU A 1 75  ? 35.18896 -11.19859 13.74143 1.000 27.39942  ? 72  LEU A HB2  1 
ATOM   1111 H HB3  . LEU A 1 75  ? 33.83121 -11.69613 14.40050 1.000 27.39942  ? 72  LEU A HB3  1 
ATOM   1112 H HG   . LEU A 1 75  ? 34.05377 -10.85000 11.70852 1.000 31.91120  ? 72  LEU A HG   1 
ATOM   1113 H HD11 . LEU A 1 75  ? 33.79548 -13.11180 11.22606 1.000 40.03062  ? 72  LEU A HD11 1 
ATOM   1114 H HD12 . LEU A 1 75  ? 35.04821 -12.95232 12.18978 1.000 40.03062  ? 72  LEU A HD12 1 
ATOM   1115 H HD13 . LEU A 1 75  ? 33.65509 -13.44491 12.77294 1.000 40.03062  ? 72  LEU A HD13 1 
ATOM   1116 H HD21 . LEU A 1 75  ? 31.88190 -11.52731 11.48609 1.000 31.95877  ? 72  LEU A HD21 1 
ATOM   1117 H HD22 . LEU A 1 75  ? 31.81890 -11.86559 13.03693 1.000 31.95877  ? 72  LEU A HD22 1 
ATOM   1118 H HD23 . LEU A 1 75  ? 31.98009 -10.35942 12.55842 1.000 31.95877  ? 72  LEU A HD23 1 
ATOM   1119 N N    . PRO A 1 76  ? 33.97116 -8.99488  16.68118 1.000 20.31393  ? 73  PRO A N    1 
ATOM   1120 C CA   . PRO A 1 76  ? 34.57604 -8.97284  18.02704 1.000 17.51861  ? 73  PRO A CA   1 
ATOM   1121 C C    . PRO A 1 76  ? 34.74013 -10.37355 18.57047 1.000 19.44587  ? 73  PRO A C    1 
ATOM   1122 O O    . PRO A 1 76  ? 34.17336 -11.35365 18.07755 1.000 20.00675  ? 73  PRO A O    1 
ATOM   1123 C CB   . PRO A 1 76  ? 33.57314 -8.17761  18.88157 1.000 21.40623  ? 73  PRO A CB   1 
ATOM   1124 C CG   . PRO A 1 76  ? 32.53590 -7.62680  17.89147 1.000 24.39618  ? 73  PRO A CG   1 
ATOM   1125 C CD   . PRO A 1 76  ? 32.59374 -8.47211  16.66270 1.000 21.69847  ? 73  PRO A CD   1 
ATOM   1126 H HA   . PRO A 1 76  ? 35.42834 -8.51023  18.00560 1.000 20.97778  ? 73  PRO A HA   1 
ATOM   1127 H HB2  . PRO A 1 76  ? 33.15415 -8.76643  19.52860 1.000 25.64292  ? 73  PRO A HB2  1 
ATOM   1128 H HB3  . PRO A 1 76  ? 34.03182 -7.45533  19.33854 1.000 25.64292  ? 73  PRO A HB3  1 
ATOM   1129 H HG2  . PRO A 1 76  ? 31.65387 -7.67423  18.29230 1.000 29.23087  ? 73  PRO A HG2  1 
ATOM   1130 H HG3  . PRO A 1 76  ? 32.75428 -6.70611  17.67809 1.000 29.23087  ? 73  PRO A HG3  1 
ATOM   1131 H HD2  . PRO A 1 76  ? 31.94871 -9.19505  16.70948 1.000 25.99362  ? 73  PRO A HD2  1 
ATOM   1132 H HD3  . PRO A 1 76  ? 32.43690 -7.93846  15.86802 1.000 25.99362  ? 73  PRO A HD3  1 
ATOM   1133 N N    . GLY A 1 77  ? 35.46105 -10.44783 19.68226 1.000 20.48815  ? 74  GLY A N    1 
ATOM   1134 C CA   . GLY A 1 77  ? 35.63128 -11.68520 20.40034 1.000 19.32751  ? 74  GLY A CA   1 
ATOM   1135 C C    . GLY A 1 77  ? 34.71271 -11.82097 21.57790 1.000 18.60634  ? 74  GLY A C    1 
ATOM   1136 O O    . GLY A 1 77  ? 33.57723 -11.36011 21.53241 1.000 21.19566  ? 74  GLY A O    1 
ATOM   1137 H H    . GLY A 1 77  ? 35.86497 -9.77785  20.03944 1.000 24.54123  ? 74  GLY A H    1 
ATOM   1138 H HA2  . GLY A 1 77  ? 35.46179 -12.42696 19.79870 1.000 23.14846  ? 74  GLY A HA2  1 
ATOM   1139 H HA3  . GLY A 1 77  ? 36.54453 -11.74203 20.72228 1.000 23.14846  ? 74  GLY A HA3  1 
ATOM   1140 N N    . GLY A 1 78  ? 35.20428 -12.48448 22.62442 1.000 19.80872  ? 75  GLY A N    1 
ATOM   1141 C CA   . GLY A 1 78  ? 34.36340 -13.01561 23.69179 1.000 19.96211  ? 75  GLY A CA   1 
ATOM   1142 C C    . GLY A 1 78  ? 34.04755 -14.45925 23.32026 1.000 25.69380  ? 75  GLY A C    1 
ATOM   1143 O O    . GLY A 1 78  ? 33.61675 -14.73267 22.19235 1.000 23.87054  ? 75  GLY A O    1 
ATOM   1144 H H    . GLY A 1 78  ? 36.04143 -12.64325 22.74096 1.000 23.72592  ? 75  GLY A H    1 
ATOM   1145 H HA2  . GLY A 1 78  ? 34.82987 -12.98809 24.54183 1.000 23.90999  ? 75  GLY A HA2  1 
ATOM   1146 H HA3  . GLY A 1 78  ? 33.54111 -12.50650 23.76618 1.000 23.90999  ? 75  GLY A HA3  1 
ATOM   1147 N N    A ASN A 1 79  ? 34.25252 -15.39913 24.23696 0.640 21.80136  ? 76  ASN A N    1 
ATOM   1148 N N    B ASN A 1 79  ? 34.26512 -15.39289 24.24652 0.360 21.95862  ? 76  ASN A N    1 
ATOM   1149 C CA   A ASN A 1 79  ? 34.09735 -16.80514 23.85318 0.640 21.28203  ? 76  ASN A CA   1 
ATOM   1150 C CA   B ASN A 1 79  ? 34.14883 -16.80408 23.88298 0.360 22.05321  ? 76  ASN A CA   1 
ATOM   1151 C C    A ASN A 1 79  ? 32.67581 -17.12430 23.40629 0.640 23.40238  ? 76  ASN A C    1 
ATOM   1152 C C    B ASN A 1 79  ? 32.72878 -17.16687 23.45941 0.360 23.42251  ? 76  ASN A C    1 
ATOM   1153 O O    A ASN A 1 79  ? 32.46788 -17.74978 22.35389 0.640 25.49537  ? 76  ASN A O    1 
ATOM   1154 O O    B ASN A 1 79  ? 32.53420 -17.84451 22.43988 0.360 25.79525  ? 76  ASN A O    1 
ATOM   1155 C CB   A ASN A 1 79  ? 34.48989 -17.70795 25.01212 0.640 22.40522  ? 76  ASN A CB   1 
ATOM   1156 C CB   B ASN A 1 79  ? 34.60351 -17.67477 25.04751 0.360 22.93821  ? 76  ASN A CB   1 
ATOM   1157 C CG   A ASN A 1 79  ? 35.96605 -17.91179 25.10386 0.640 33.01054  ? 76  ASN A CG   1 
ATOM   1158 C CG   B ASN A 1 79  ? 34.75947 -19.12519 24.65872 0.360 24.71071  ? 76  ASN A CG   1 
ATOM   1159 O OD1  A ASN A 1 79  ? 36.69159 -17.72520 24.12422 0.640 37.59469  ? 76  ASN A OD1  1 
ATOM   1160 O OD1  B ASN A 1 79  ? 35.14081 -19.45195 23.53751 0.360 32.61477  ? 76  ASN A OD1  1 
ATOM   1161 N ND2  A ASN A 1 79  ? 36.43713 -18.29774 26.26230 0.640 36.68283  ? 76  ASN A ND2  1 
ATOM   1162 N ND2  B ASN A 1 79  ? 34.45084 -20.01259 25.59033 0.360 36.94986  ? 76  ASN A ND2  1 
ATOM   1163 H HA   A ASN A 1 79  ? 34.69084 -16.97540 23.10506 0.640 25.49389  ? 76  ASN A HA   1 
ATOM   1164 H HA   B ASN A 1 79  ? 34.72987 -16.97794 23.12597 0.360 26.41930  ? 76  ASN A HA   1 
ATOM   1165 H HB2  A ASN A 1 79  ? 34.18937 -17.30658 25.84248 0.640 26.84171  ? 76  ASN A HB2  1 
ATOM   1166 H HB2  B ASN A 1 79  ? 35.46188 -17.35472 25.36638 0.360 27.48130  ? 76  ASN A HB2  1 
ATOM   1167 H HB3  A ASN A 1 79  ? 34.07311 -18.57574 24.89319 0.640 26.84171  ? 76  ASN A HB3  1 
ATOM   1168 H HB3  B ASN A 1 79  ? 33.94527 -17.62279 25.75809 0.360 27.48130  ? 76  ASN A HB3  1 
ATOM   1169 H HD21 A ASN A 1 79  ? 35.90235 -18.42148 26.92434 0.640 43.97485  ? 76  ASN A HD21 1 
ATOM   1170 H HD21 B ASN A 1 79  ? 34.18005 -19.74864 26.36274 0.360 44.29528  ? 76  ASN A HD21 1 
ATOM   1171 H HD22 A ASN A 1 79  ? 37.28146 -18.42760 26.36148 0.640 43.97485  ? 76  ASN A HD22 1 
ATOM   1172 H HD22 B ASN A 1 79  ? 34.52103 -20.85332 25.42346 0.360 44.29528  ? 76  ASN A HD22 1 
ATOM   1173 N N    A LEU A 1 80  ? 31.67409 -16.69437 24.18184 0.640 22.43203  ? 77  LEU A N    1 
ATOM   1174 N N    B LEU A 1 80  ? 31.71630 -16.70808 24.20612 0.360 22.67487  ? 77  LEU A N    1 
ATOM   1175 C CA   A LEU A 1 80  ? 30.29567 -17.04271 23.84547 0.640 24.39791  ? 77  LEU A CA   1 
ATOM   1176 C CA   B LEU A 1 80  ? 30.34131 -17.05229 23.84379 0.360 24.93368  ? 77  LEU A CA   1 
ATOM   1177 C C    A LEU A 1 80  ? 29.78770 -16.21800 22.67581 0.640 27.40215  ? 77  LEU A C    1 
ATOM   1178 C C    B LEU A 1 80  ? 29.85987 -16.25102 22.64060 0.360 27.37829  ? 77  LEU A C    1 
ATOM   1179 O O    A LEU A 1 80  ? 28.98950 -16.70724 21.86446 0.640 26.02261  ? 77  LEU A O    1 
ATOM   1180 O O    B LEU A 1 80  ? 29.10573 -16.76831 21.80390 0.360 25.68972  ? 77  LEU A O    1 
ATOM   1181 C CB   A LEU A 1 80  ? 29.41893 -16.86101 25.07893 0.640 21.51019  ? 77  LEU A CB   1 
ATOM   1182 C CB   B LEU A 1 80  ? 29.40419 -16.83520 25.03263 0.360 22.18477  ? 77  LEU A CB   1 
ATOM   1183 C CG   A LEU A 1 80  ? 29.80512 -17.79588 26.24054 0.640 28.82347  ? 77  LEU A CG   1 
ATOM   1184 C CG   B LEU A 1 80  ? 29.27617 -18.00548 26.01451 0.360 32.31907  ? 77  LEU A CG   1 
ATOM   1185 C CD1  A LEU A 1 80  ? 28.93202 -17.53559 27.46173 0.640 40.68258  ? 77  LEU A CD1  1 
ATOM   1186 C CD1  B LEU A 1 80  ? 30.57973 -18.19779 26.77985 0.360 23.01046  ? 77  LEU A CD1  1 
ATOM   1187 C CD2  A LEU A 1 80  ? 29.71255 -19.25377 25.78856 0.640 43.27535  ? 77  LEU A CD2  1 
ATOM   1188 C CD2  B LEU A 1 80  ? 28.09107 -17.79503 26.96409 0.360 33.53468  ? 77  LEU A CD2  1 
ATOM   1189 H H    A LEU A 1 80  ? 31.76615 -16.21292 24.88847 0.640 26.87389  ? 77  LEU A H    1 
ATOM   1190 H H    B LEU A 1 80  ? 31.79833 -16.21228 24.90401 0.360 27.16529  ? 77  LEU A H    1 
ATOM   1191 H HA   A LEU A 1 80  ? 30.23764 -17.97501 23.58403 0.640 29.23294  ? 77  LEU A HA   1 
ATOM   1192 H HA   B LEU A 1 80  ? 30.31378 -17.99366 23.61151 0.360 29.87587  ? 77  LEU A HA   1 
ATOM   1193 H HB2  A LEU A 1 80  ? 29.50230 -15.94626 25.39068 0.640 25.76767  ? 77  LEU A HB2  1 
ATOM   1194 H HB2  B LEU A 1 80  ? 29.72792 -16.07231 25.53672 0.360 26.57717  ? 77  LEU A HB2  1 
ATOM   1195 H HB3  A LEU A 1 80  ? 28.49772 -17.04700 24.83878 0.640 25.76767  ? 77  LEU A HB3  1 
ATOM   1196 H HB3  B LEU A 1 80  ? 28.51631 -16.65223 24.68755 0.360 26.57717  ? 77  LEU A HB3  1 
ATOM   1197 H HG   A LEU A 1 80  ? 30.72179 -17.62077 26.50503 0.640 34.54361  ? 77  LEU A HG   1 
ATOM   1198 H HG   B LEU A 1 80  ? 29.10217 -18.82133 25.51952 0.360 38.73833  ? 77  LEU A HG   1 
ATOM   1199 H HD11 A LEU A 1 80  ? 29.19682 -18.13887 28.17365 0.640 48.77455  ? 77  LEU A HD11 1 
ATOM   1200 H HD11 B LEU A 1 80  ? 30.47561 -18.93593 27.40050 0.360 27.56800  ? 77  LEU A HD11 1 
ATOM   1201 H HD12 A LEU A 1 80  ? 29.05225 -16.61590 27.74567 0.640 48.77455  ? 77  LEU A HD12 1 
ATOM   1202 H HD12 B LEU A 1 80  ? 31.29026 -18.39359 26.14921 0.360 27.56800  ? 77  LEU A HD12 1 
ATOM   1203 H HD13 A LEU A 1 80  ? 28.00407 -17.69014 27.22523 0.640 48.77455  ? 77  LEU A HD13 1 
ATOM   1204 H HD13 B LEU A 1 80  ? 30.78379 -17.38340 27.26568 0.360 27.56800  ? 77  LEU A HD13 1 
ATOM   1205 H HD21 A LEU A 1 80  ? 29.89046 -19.83149 26.54717 0.640 51.88587  ? 77  LEU A HD21 1 
ATOM   1206 H HD21 B LEU A 1 80  ? 28.04510 -18.54135 27.58199 0.360 40.19707  ? 77  LEU A HD21 1 
ATOM   1207 H HD22 A LEU A 1 80  ? 28.82067 -19.42230 25.44643 0.640 51.88587  ? 77  LEU A HD22 1 
ATOM   1208 H HD22 B LEU A 1 80  ? 28.22168 -16.96787 27.45363 0.360 40.19707  ? 77  LEU A HD22 1 
ATOM   1209 H HD23 A LEU A 1 80  ? 30.36915 -19.41077 25.09206 0.640 51.88587  ? 77  LEU A HD23 1 
ATOM   1210 H HD23 B LEU A 1 80  ? 27.27411 -17.74582 26.44347 0.360 40.19707  ? 77  LEU A HD23 1 
ATOM   1211 N N    . GLY A 1 81  ? 30.28832 -14.99432 22.53153 1.000 23.33101  ? 78  GLY A N    1 
ATOM   1212 C CA   . GLY A 1 81  ? 29.95727 -14.23096 21.35432 1.000 22.93515  ? 78  GLY A CA   1 
ATOM   1213 C C    . GLY A 1 81  ? 30.45380 -14.89064 20.08089 1.000 25.19666  ? 78  GLY A C    1 
ATOM   1214 O O    . GLY A 1 81  ? 29.73051 -14.97790 19.07633 1.000 23.66899  ? 78  GLY A O    1 
ATOM   1215 H HA2  . GLY A 1 81  ? 28.99389 -14.13539 21.29378 1.000 27.47763  ? 78  GLY A HA2  1 
ATOM   1216 H HA3  . GLY A 1 81  ? 30.35855 -13.35024 21.41915 1.000 27.47763  ? 78  GLY A HA3  1 
ATOM   1217 N N    . ALA A 1 82  ? 31.69956 -15.36689 20.10306 1.000 20.87066  ? 79  ALA A N    1 
ATOM   1218 C CA   . ALA A 1 82  ? 32.25143 -15.99248 18.90994 1.000 21.75950  ? 79  ALA A CA   1 
ATOM   1219 C C    . ALA A 1 82  ? 31.53835 -17.28840 18.57367 1.000 21.51348  ? 79  ALA A C    1 
ATOM   1220 O O    . ALA A 1 82  ? 31.37570 -17.62114 17.39145 1.000 26.09179  ? 79  ALA A O    1 
ATOM   1221 C CB   . ALA A 1 82  ? 33.74407 -16.27535 19.10390 1.000 23.15339  ? 79  ALA A CB   1 
ATOM   1222 H H    . ALA A 1 82  ? 32.22981 -15.33967 20.77959 1.000 25.00025  ? 79  ALA A H    1 
ATOM   1223 H HA   . ALA A 1 82  ? 32.14356 -15.37662 18.16834 1.000 26.06685  ? 79  ALA A HA   1 
ATOM   1224 H HB1  . ALA A 1 82  ? 34.10048 -16.66302 18.28930 1.000 27.73952  ? 79  ALA A HB1  1 
ATOM   1225 H HB2  . ALA A 1 82  ? 34.20034 -15.44236 19.30099 1.000 27.73952  ? 79  ALA A HB2  1 
ATOM   1226 H HB3  . ALA A 1 82  ? 33.85472 -16.89563 19.84140 1.000 27.73952  ? 79  ALA A HB3  1 
ATOM   1227 N N    A GLN A 1 83  ? 31.10433 -18.03137 19.59157 0.532 21.99185  ? 80  GLN A N    1 
ATOM   1228 N N    B GLN A 1 83  ? 31.11813 -18.04129 19.58381 0.468 22.04346  ? 80  GLN A N    1 
ATOM   1229 C CA   A GLN A 1 83  ? 30.34845 -19.26191 19.34862 0.532 25.83726  ? 80  GLN A CA   1 
ATOM   1230 C CA   B GLN A 1 83  ? 30.35093 -19.25061 19.30093 0.468 25.76298  ? 80  GLN A CA   1 
ATOM   1231 C C    A GLN A 1 83  ? 29.01375 -18.94824 18.67855 0.532 29.30007  ? 80  GLN A C    1 
ATOM   1232 C C    B GLN A 1 83  ? 29.04349 -18.89658 18.60810 0.468 29.51873  ? 80  GLN A C    1 
ATOM   1233 O O    A GLN A 1 83  ? 28.58682 -19.65871 17.76035 0.532 27.98822  ? 80  GLN A O    1 
ATOM   1234 O O    B GLN A 1 83  ? 28.66032 -19.52764 17.61411 0.468 27.19789  ? 80  GLN A O    1 
ATOM   1235 C CB   A GLN A 1 83  ? 30.14733 -20.02583 20.67388 0.532 27.48591  ? 80  GLN A CB   1 
ATOM   1236 C CB   B GLN A 1 83  ? 30.08910 -20.02924 20.59358 0.468 27.75523  ? 80  GLN A CB   1 
ATOM   1237 C CG   A GLN A 1 83  ? 31.45382 -20.52706 21.33203 0.532 39.08669  ? 80  GLN A CG   1 
ATOM   1238 C CG   B GLN A 1 83  ? 29.20110 -21.24236 20.38586 0.468 30.65877  ? 80  GLN A CG   1 
ATOM   1239 C CD   A GLN A 1 83  ? 31.24870 -21.33586 22.61830 0.532 44.19319  ? 80  GLN A CD   1 
ATOM   1240 C CD   B GLN A 1 83  ? 28.85315 -21.94577 21.67867 0.468 41.11579  ? 80  GLN A CD   1 
ATOM   1241 O OE1  A GLN A 1 83  ? 30.23651 -22.02036 22.78443 0.532 49.84121  ? 80  GLN A OE1  1 
ATOM   1242 O OE1  B GLN A 1 83  ? 29.28259 -21.53767 22.75474 0.468 54.55323  ? 80  GLN A OE1  1 
ATOM   1243 N NE2  A GLN A 1 83  ? 32.22004 -21.26019 23.53261 0.532 43.93842  ? 80  GLN A NE2  1 
ATOM   1244 N NE2  B GLN A 1 83  ? 28.06281 -23.01006 21.58015 0.468 58.39033  ? 80  GLN A NE2  1 
ATOM   1245 H HA   A GLN A 1 83  ? 30.85110 -19.84129 18.75485 0.532 30.96016  ? 80  GLN A HA   1 
ATOM   1246 H HA   B GLN A 1 83  ? 30.86514 -19.82755 18.71473 0.468 30.87103  ? 80  GLN A HA   1 
ATOM   1247 H HB2  A GLN A 1 83  ? 29.70855 -19.43590 21.30662 0.532 32.93855  ? 80  GLN A HB2  1 
ATOM   1248 H HB2  B GLN A 1 83  ? 30.93609 -20.33631 20.95302 0.468 33.26172  ? 80  GLN A HB2  1 
ATOM   1249 H HB3  A GLN A 1 83  ? 29.59027 -20.80104 20.50175 0.532 32.93855  ? 80  GLN A HB3  1 
ATOM   1250 H HB3  B GLN A 1 83  ? 29.65121 -19.44333 21.23066 0.468 33.26172  ? 80  GLN A HB3  1 
ATOM   1251 H HG2  A GLN A 1 83  ? 31.91996 -21.09629 20.69989 0.532 46.85948  ? 80  GLN A HG2  1 
ATOM   1252 H HG2  B GLN A 1 83  ? 28.37326 -20.95935 19.96696 0.468 36.74597  ? 80  GLN A HG2  1 
ATOM   1253 H HG3  A GLN A 1 83  ? 32.00278 -19.75880 21.55410 0.532 46.85948  ? 80  GLN A HG3  1 
ATOM   1254 H HG3  B GLN A 1 83  ? 29.66199 -21.87663 19.81473 0.468 36.74597  ? 80  GLN A HG3  1 
ATOM   1255 H HE21 A GLN A 1 83  ? 32.91456 -20.77556 23.38303 0.532 52.68156  ? 80  GLN A HE21 1 
ATOM   1256 H HE21 B GLN A 1 83  ? 27.77803 -23.26432 20.80953 0.468 70.02385  ? 80  GLN A HE21 1 
ATOM   1257 H HE22 A GLN A 1 83  ? 32.15073 -21.69611 24.27069 0.532 52.68156  ? 80  GLN A HE22 1 
ATOM   1258 H HE22 B GLN A 1 83  ? 27.83626 -23.44433 22.28703 0.468 70.02385  ? 80  GLN A HE22 1 
ATOM   1259 N N    . ASN A 1 84  ? 28.36092 -17.85722 19.09301 1.000 24.85654  ? 81  ASN A N    1 
ATOM   1260 C CA   . ASN A 1 84  ? 27.12293 -17.43385 18.43234 1.000 24.66922  ? 81  ASN A CA   1 
ATOM   1261 C C    . ASN A 1 84  ? 27.36325 -17.00019 16.99569 1.000 27.81381  ? 81  ASN A C    1 
ATOM   1262 O O    . ASN A 1 84  ? 26.55947 -17.30892 16.10932 1.000 25.27153  ? 81  ASN A O    1 
ATOM   1263 C CB   . ASN A 1 84  ? 26.44262 -16.31034 19.23253 1.000 28.64236  ? 81  ASN A CB   1 
ATOM   1264 C CG   . ASN A 1 84  ? 25.77704 -16.81775 20.48451 1.000 35.58127  ? 81  ASN A CG   1 
ATOM   1265 O OD1  . ASN A 1 84  ? 25.26365 -17.91604 20.51698 1.000 36.91988  ? 81  ASN A OD1  1 
ATOM   1266 N ND2  . ASN A 1 84  ? 25.78097 -16.00461 21.53909 1.000 30.66122  ? 81  ASN A ND2  1 
ATOM   1267 H HA   . ASN A 1 84  ? 26.51965 -18.19313 18.41149 1.000 29.55852  ? 81  ASN A HA   1 
ATOM   1268 H HB2  . ASN A 1 84  ? 27.11014 -15.65552 19.49045 1.000 34.32628  ? 81  ASN A HB2  1 
ATOM   1269 H HB3  . ASN A 1 84  ? 25.76445 -15.89246 18.67903 1.000 34.32628  ? 81  ASN A HB3  1 
ATOM   1270 H HD21 . ASN A 1 84  ? 26.15222 -15.23082 21.48406 1.000 36.74891  ? 81  ASN A HD21 1 
ATOM   1271 H HD22 . ASN A 1 84  ? 25.41225 -16.25326 22.27518 1.000 36.74891  ? 81  ASN A HD22 1 
ATOM   1272 N N    . LEU A 1 85  ? 28.45939 -16.28153 16.73272 1.000 21.78350  ? 82  LEU A N    1 
ATOM   1273 C CA   . LEU A 1 85  ? 28.79821 -15.90765 15.36338 1.000 21.21438  ? 82  LEU A CA   1 
ATOM   1274 C C    . LEU A 1 85  ? 29.05554 -17.14513 14.50730 1.000 27.35008  ? 82  LEU A C    1 
ATOM   1275 O O    . LEU A 1 85  ? 28.73799 -17.15496 13.31394 1.000 24.05340  ? 82  LEU A O    1 
ATOM   1276 C CB   . LEU A 1 85  ? 30.06325 -15.02342 15.31313 1.000 21.40307  ? 82  LEU A CB   1 
ATOM   1277 C CG   . LEU A 1 85  ? 29.99303 -13.65647 16.00504 1.000 26.84406  ? 82  LEU A CG   1 
ATOM   1278 C CD1  . LEU A 1 85  ? 31.33644 -12.95869 15.98270 1.000 26.84185  ? 82  LEU A CD1  1 
ATOM   1279 C CD2  . LEU A 1 85  ? 28.96513 -12.79872 15.31583 1.000 28.49700  ? 82  LEU A CD2  1 
ATOM   1280 H H    . LEU A 1 85  ? 29.01652 -16.00179 17.32514 1.000 26.09565  ? 82  LEU A H    1 
ATOM   1281 H HA   . LEU A 1 85  ? 28.04910 -15.40090 15.01277 1.000 25.41270  ? 82  LEU A HA   1 
ATOM   1282 H HB2  . LEU A 1 85  ? 30.78648 -15.51487 15.73302 1.000 25.63913  ? 82  LEU A HB2  1 
ATOM   1283 H HB3  . LEU A 1 85  ? 30.27279 -14.85681 14.38080 1.000 25.63913  ? 82  LEU A HB3  1 
ATOM   1284 H HG   . LEU A 1 85  ? 29.74216 -13.78660 16.93296 1.000 32.16832  ? 82  LEU A HG   1 
ATOM   1285 H HD11 . LEU A 1 85  ? 31.27538 -12.13943 16.49844 1.000 32.16567  ? 82  LEU A HD11 1 
ATOM   1286 H HD12 . LEU A 1 85  ? 32.00362 -13.54554 16.37178 1.000 32.16567  ? 82  LEU A HD12 1 
ATOM   1287 H HD13 . LEU A 1 85  ? 31.57098 -12.75446 15.06391 1.000 32.16567  ? 82  LEU A HD13 1 
ATOM   1288 H HD21 . LEU A 1 85  ? 28.96674 -11.91719 15.72056 1.000 34.15185  ? 82  LEU A HD21 1 
ATOM   1289 H HD22 . LEU A 1 85  ? 29.19006 -12.73100 14.37470 1.000 34.15185  ? 82  LEU A HD22 1 
ATOM   1290 H HD23 . LEU A 1 85  ? 28.09186 -13.20828 15.41858 1.000 34.15185  ? 82  LEU A HD23 1 
ATOM   1291 N N    . SER A 1 86  ? 29.68316 -18.15943 15.09497 1.000 22.08752  ? 83  SER A N    1 
ATOM   1292 C CA   . SER A 1 86  ? 30.08895 -19.36915 14.37366 1.000 24.40905  ? 83  SER A CA   1 
ATOM   1293 C C    . SER A 1 86  ? 28.90779 -20.21844 13.94672 1.000 32.83375  ? 83  SER A C    1 
ATOM   1294 O O    . SER A 1 86  ? 29.02422 -21.00458 13.00187 1.000 29.03547  ? 83  SER A O    1 
ATOM   1295 C CB   . SER A 1 86  ? 30.99934 -20.23960 15.24325 1.000 24.58978  ? 83  SER A CB   1 
ATOM   1296 O OG   . SER A 1 86  ? 32.21520 -19.55801 15.50356 1.000 27.63275  ? 83  SER A OG   1 
ATOM   1297 H H    . SER A 1 86  ? 29.89255 -18.17698 15.92891 1.000 26.46048  ? 83  SER A H    1 
ATOM   1298 H HA   . SER A 1 86  ? 30.57289 -19.07478 13.58623 1.000 29.24631  ? 83  SER A HA   1 
ATOM   1299 H HB2  . SER A 1 86  ? 30.55299 -20.42868 16.08343 1.000 29.46318  ? 83  SER A HB2  1 
ATOM   1300 H HB3  . SER A 1 86  ? 31.19113 -21.06761 14.77578 1.000 29.46318  ? 83  SER A HB3  1 
ATOM   1301 H HG   . SER A 1 86  ? 32.72151 -20.04100 15.96829 1.000 33.11475  ? 83  SER A HG   1 
ATOM   1302 N N    . GLU A 1 87  ? 27.80302 -20.12273 14.65977 1.000 29.00480  ? 84  GLU A N    1 
ATOM   1303 C CA   . GLU A 1 87  ? 26.63915 -20.95733 14.42216 1.000 30.06577  ? 84  GLU A CA   1 
ATOM   1304 C C    . GLU A 1 87  ? 25.63493 -20.29244 13.48702 1.000 32.67619  ? 84  GLU A C    1 
ATOM   1305 O O    . GLU A 1 87  ? 24.64722 -20.92179 13.10381 1.000 36.51132  ? 84  GLU A O    1 
ATOM   1306 C CB   . GLU A 1 87  ? 25.96938 -21.29872 15.75212 1.000 32.44604  ? 84  GLU A CB   1 
ATOM   1307 C CG   . GLU A 1 87  ? 26.75783 -22.27909 16.62565 1.000 39.51590  ? 84  GLU A CG   1 
ATOM   1308 C CD   . GLU A 1 87  ? 26.15762 -22.48828 18.02210 1.000 52.57678  ? 84  GLU A CD   1 
ATOM   1309 O OE1  . GLU A 1 87  ? 25.04649 -21.99500 18.29957 1.000 63.96739  ? 84  GLU A OE1  1 
ATOM   1310 O OE2  . GLU A 1 87  ? 26.82234 -23.14283 18.85192 1.000 72.96845  ? 84  GLU A OE2  1 
ATOM   1311 H H    . GLU A 1 87  ? 27.69812 -19.56578 15.30661 1.000 34.76121  ? 84  GLU A H    1 
ATOM   1312 H HA   . GLU A 1 87  ? 26.91887 -21.79085 14.01241 1.000 36.03437  ? 84  GLU A HA   1 
ATOM   1313 H HB2  . GLU A 1 87  ? 25.85520 -20.48013 16.25983 1.000 38.89070  ? 84  GLU A HB2  1 
ATOM   1314 H HB3  . GLU A 1 87  ? 25.10494 -21.69893 15.56914 1.000 38.89070  ? 84  GLU A HB3  1 
ATOM   1315 H HG2  . GLU A 1 87  ? 26.78184 -23.14163 16.18252 1.000 47.37453  ? 84  GLU A HG2  1 
ATOM   1316 H HG3  . GLU A 1 87  ? 27.65925 -21.93951 16.73972 1.000 47.37453  ? 84  GLU A HG3  1 
ATOM   1317 N N    . SER A 1 88  ? 25.86672 -19.04624 13.08810 1.000 27.87432  ? 85  SER A N    1 
ATOM   1318 C CA   . SER A 1 88  ? 24.85607 -18.26683 12.39400 1.000 31.93754  ? 85  SER A CA   1 
ATOM   1319 C C    . SER A 1 88  ? 25.01421 -18.37068 10.88228 1.000 28.86690  ? 85  SER A C    1 
ATOM   1320 O O    . SER A 1 88  ? 26.05644 -18.01220 10.31080 1.000 26.88377  ? 85  SER A O    1 
ATOM   1321 C CB   . SER A 1 88  ? 24.92405 -16.80308 12.79784 1.000 26.07107  ? 85  SER A CB   1 
ATOM   1322 O OG   . SER A 1 88  ? 24.20661 -16.00274 11.89312 1.000 31.13922  ? 85  SER A OG   1 
ATOM   1323 H H    . SER A 1 88  ? 26.60881 -18.62912 13.21025 1.000 33.40464  ? 85  SER A H    1 
ATOM   1324 H HA   . SER A 1 88  ? 23.99310 -18.63772 12.63611 1.000 38.28050  ? 85  SER A HA   1 
ATOM   1325 H HB2  . SER A 1 88  ? 24.54038 -16.70127 13.68291 1.000 31.24074  ? 85  SER A HB2  1 
ATOM   1326 H HB3  . SER A 1 88  ? 25.85168 -16.51961 12.80376 1.000 31.24074  ? 85  SER A HB3  1 
ATOM   1327 H HG   . SER A 1 88  ? 24.29941 -15.19165 12.09091 1.000 37.32251  ? 85  SER A HG   1 
ATOM   1328 N N    . ALA A 1 89  ? 23.93858 -18.79664 10.21782 1.000 32.12345  ? 86  ALA A N    1 
ATOM   1329 C CA   . ALA A 1 89  ? 23.96704 -18.86472 8.76326  1.000 33.81201  ? 86  ALA A CA   1 
ATOM   1330 C C    . ALA A 1 89  ? 23.99311 -17.49560 8.11978  1.000 30.66620  ? 86  ALA A C    1 
ATOM   1331 O O    . ALA A 1 89  ? 24.57343 -17.33568 7.03178  1.000 27.58098  ? 86  ALA A O    1 
ATOM   1332 C CB   . ALA A 1 89  ? 22.74136 -19.65079 8.25507  1.000 43.53521  ? 86  ALA A CB   1 
ATOM   1333 H H    . ALA A 1 89  ? 23.19890 -19.04547 10.57916 1.000 38.50359  ? 86  ALA A H    1 
ATOM   1334 H HA   . ALA A 1 89  ? 24.77530 -19.33139 8.49900  1.000 40.52987  ? 86  ALA A HA   1 
ATOM   1335 H HB1  . ALA A 1 89  ? 22.78049 -19.70582 7.28742  1.000 52.19770  ? 86  ALA A HB1  1 
ATOM   1336 H HB2  . ALA A 1 89  ? 22.75675 -20.54190 8.63794  1.000 52.19770  ? 86  ALA A HB2  1 
ATOM   1337 H HB3  . ALA A 1 89  ? 21.93389 -19.18756 8.52765  1.000 52.19770  ? 86  ALA A HB3  1 
ATOM   1338 N N    . ALA A 1 90  ? 23.38672 -16.47827 8.75455  1.000 28.02730  ? 87  ALA A N    1 
ATOM   1339 C CA   . ALA A 1 90  ? 23.48313 -15.13860 8.18731  1.000 25.49471  ? 87  ALA A CA   1 
ATOM   1340 C C    . ALA A 1 90  ? 24.92198 -14.63119 8.19090  1.000 27.01563  ? 87  ALA A C    1 
ATOM   1341 O O    . ALA A 1 90  ? 25.35550 -13.93941 7.26743  1.000 28.87366  ? 87  ALA A O    1 
ATOM   1342 C CB   . ALA A 1 90  ? 22.58987 -14.16906 8.98925  1.000 36.38157  ? 87  ALA A CB   1 
ATOM   1343 H H    . ALA A 1 90  ? 22.93444 -16.54143 9.48329  1.000 33.58821  ? 87  ALA A H    1 
ATOM   1344 H HA   . ALA A 1 90  ? 23.17256 -15.16985 7.26891  1.000 30.54910  ? 87  ALA A HA   1 
ATOM   1345 H HB1  . ALA A 1 90  ? 22.67222 -13.27900 8.61255  1.000 43.61334  ? 87  ALA A HB1  1 
ATOM   1346 H HB2  . ALA A 1 90  ? 21.66889 -14.46824 8.93275  1.000 43.61334  ? 87  ALA A HB2  1 
ATOM   1347 H HB3  . ALA A 1 90  ? 22.88004 -14.16467 9.91482  1.000 43.61334  ? 87  ALA A HB3  1 
ATOM   1348 N N    . VAL A 1 91  ? 25.67153 -14.93193 9.25711  1.000 27.68663  ? 88  VAL A N    1 
ATOM   1349 C CA   . VAL A 1 91  ? 27.08149 -14.53398 9.27583  1.000 25.87358  ? 88  VAL A CA   1 
ATOM   1350 C C    . VAL A 1 91  ? 27.85129 -15.23209 8.17111  1.000 23.70268  ? 88  VAL A C    1 
ATOM   1351 O O    . VAL A 1 91  ? 28.69814 -14.62276 7.51334  1.000 25.44688  ? 88  VAL A O    1 
ATOM   1352 C CB   . VAL A 1 91  ? 27.70314 -14.81633 10.66268 1.000 25.28046  ? 88  VAL A CB   1 
ATOM   1353 C CG1  . VAL A 1 91  ? 29.17820 -14.52753 10.62225 1.000 27.25783  ? 88  VAL A CG1  1 
ATOM   1354 C CG2  . VAL A 1 91  ? 27.02948 -13.93570 11.70377 1.000 30.46282  ? 88  VAL A CG2  1 
ATOM   1355 H H    . VAL A 1 91  ? 25.39761 -15.35033 9.95676  1.000 33.17941  ? 88  VAL A H    1 
ATOM   1356 H HA   . VAL A 1 91  ? 27.12798 -13.57884 9.11318  1.000 31.00375  ? 88  VAL A HA   1 
ATOM   1357 H HB   . VAL A 1 91  ? 27.57330 -15.74729 10.90218 1.000 30.29201  ? 88  VAL A HB   1 
ATOM   1358 H HG11 . VAL A 1 91  ? 29.54980 -14.65715 11.50882 1.000 32.66484  ? 88  VAL A HG11 1 
ATOM   1359 H HG12 . VAL A 1 91  ? 29.60156 -15.13362 9.99429  1.000 32.66484  ? 88  VAL A HG12 1 
ATOM   1360 H HG13 . VAL A 1 91  ? 29.31267 -13.60987 10.33815 1.000 32.66484  ? 88  VAL A HG13 1 
ATOM   1361 H HG21 . VAL A 1 91  ? 27.44866 -14.08798 12.56517 1.000 36.51083  ? 88  VAL A HG21 1 
ATOM   1362 H HG22 . VAL A 1 91  ? 27.13227 -13.00637 11.44555 1.000 36.51083  ? 88  VAL A HG22 1 
ATOM   1363 H HG23 . VAL A 1 91  ? 26.08787 -14.16421 11.74911 1.000 36.51083  ? 88  VAL A HG23 1 
ATOM   1364 N N    . LYS A 1 92  ? 27.59995 -16.53819 7.97292  1.000 24.73609  ? 89  LYS A N    1 
ATOM   1365 C CA   . LYS A 1 92  ? 28.29313 -17.26969 6.91164  1.000 28.38990  ? 89  LYS A CA   1 
ATOM   1366 C C    . LYS A 1 92  ? 28.12769 -16.56210 5.57547  1.000 22.90811  ? 89  LYS A C    1 
ATOM   1367 O O    . LYS A 1 92  ? 29.08499 -16.37241 4.81396  1.000 27.92539  ? 89  LYS A O    1 
ATOM   1368 C CB   . LYS A 1 92  ? 27.73706 -18.69304 6.82697  1.000 27.78848  ? 89  LYS A CB   1 
ATOM   1369 C CG   . LYS A 1 92  ? 28.51851 -19.61176 5.87148  1.000 33.93056  ? 89  LYS A CG   1 
ATOM   1370 C CD   . LYS A 1 92  ? 27.92909 -21.03351 5.78945  1.000 47.32030  ? 89  LYS A CD   1 
ATOM   1371 C CE   . LYS A 1 92  ? 27.65793 -21.69520 7.15498  1.000 63.80929  ? 89  LYS A CE   1 
ATOM   1372 N NZ   . LYS A 1 92  ? 28.83030 -22.18010 7.95724  1.000 48.20207  ? 89  LYS A NZ   1 
ATOM   1373 H H    . LYS A 1 92  ? 27.04471 -17.00878 8.43101  1.000 29.63875  ? 89  LYS A H    1 
ATOM   1374 H HA   . LYS A 1 92  ? 29.23922 -17.31703 7.12036  1.000 34.02333  ? 89  LYS A HA   1 
ATOM   1375 H HB2  . LYS A 1 92  ? 27.76676 -19.09187 7.71069  1.000 33.30162  ? 89  LYS A HB2  1 
ATOM   1376 H HB3  . LYS A 1 92  ? 26.82037 -18.65088 6.51265  1.000 33.30162  ? 89  LYS A HB3  1 
ATOM   1377 H HG2  . LYS A 1 92  ? 28.50073 -19.22906 4.98035  1.000 40.67212  ? 89  LYS A HG2  1 
ATOM   1378 H HG3  . LYS A 1 92  ? 29.43428 -19.68546 6.18268  1.000 40.67212  ? 89  LYS A HG3  1 
ATOM   1379 H HD2  . LYS A 1 92  ? 27.08526 -20.99164 5.31292  1.000 56.73981  ? 89  LYS A HD2  1 
ATOM   1380 H HD3  . LYS A 1 92  ? 28.55332 -21.60007 5.30961  1.000 56.73981  ? 89  LYS A HD3  1 
ATOM   1381 H HE2  . LYS A 1 92  ? 27.19372 -21.04819 7.70887  1.000 76.52660  ? 89  LYS A HE2  1 
ATOM   1382 H HE3  . LYS A 1 92  ? 27.09126 -22.46723 7.00090  1.000 76.52660  ? 89  LYS A HE3  1 
ATOM   1383 H HZ1  . LYS A 1 92  ? 28.55888 -22.44838 8.76127  1.000 57.79793  ? 89  LYS A HZ1  1 
ATOM   1384 H HZ2  . LYS A 1 92  ? 29.22186 -22.86292 7.54187  1.000 57.79793  ? 89  LYS A HZ2  1 
ATOM   1385 H HZ3  . LYS A 1 92  ? 29.42338 -21.52399 8.05666  1.000 57.79793  ? 89  LYS A HZ3  1 
ATOM   1386 N N    . GLU A 1 93  ? 26.88967 -16.15889 5.27752  1.000 28.03617  ? 90  GLU A N    1 
ATOM   1387 C CA   . GLU A 1 93  ? 26.59910 -15.54100 3.98407  1.000 28.10309  ? 90  GLU A CA   1 
ATOM   1388 C C    . GLU A 1 93  ? 27.28888 -14.19429 3.84438  1.000 31.06444  ? 90  GLU A C    1 
ATOM   1389 O O    . GLU A 1 93  ? 27.83869 -13.87554 2.78912  1.000 27.09160  ? 90  GLU A O    1 
ATOM   1390 C CB   . GLU A 1 93  ? 25.07147 -15.43812 3.84692  1.000 34.25156  ? 90  GLU A CB   1 
ATOM   1391 C CG   . GLU A 1 93  ? 24.47470 -14.66939 2.68365  1.000 66.00602  ? 90  GLU A CG   1 
ATOM   1392 C CD   . GLU A 1 93  ? 22.94186 -14.58125 2.81627  1.000 86.60953  ? 90  GLU A CD   1 
ATOM   1393 O OE1  . GLU A 1 93  ? 22.35355 -15.41236 3.55219  1.000 72.35119  ? 90  GLU A OE1  1 
ATOM   1394 O OE2  . GLU A 1 93  ? 22.33057 -13.68123 2.20754  1.000 91.10688  ? 90  GLU A OE2  1 
ATOM   1395 H H    . GLU A 1 93  ? 26.20998 -16.23072 5.79951  1.000 33.59885  ? 90  GLU A H    1 
ATOM   1396 H HA   . GLU A 1 93  ? 26.93548 -16.08610 3.25564  1.000 33.67916  ? 90  GLU A HA   1 
ATOM   1397 H HB2  . GLU A 1 93  ? 24.72576 -16.34197 3.78022  1.000 41.05732  ? 90  GLU A HB2  1 
ATOM   1398 H HB3  . GLU A 1 93  ? 24.73692 -15.01356 4.65235  1.000 41.05732  ? 90  GLU A HB3  1 
ATOM   1399 H HG2  . GLU A 1 93  ? 24.83545 -13.76906 2.67144  1.000 79.16267  ? 90  GLU A HG2  1 
ATOM   1400 H HG3  . GLU A 1 93  ? 24.68678 -15.12307 1.85293  1.000 79.16267  ? 90  GLU A HG3  1 
ATOM   1401 N N    . ILE A 1 94  ? 27.29895 -13.38960 4.90850  1.000 27.29378  ? 91  ILE A N    1 
ATOM   1402 C CA   . ILE A 1 94  ? 27.98253 -12.10342 4.83574  1.000 23.57499  ? 91  ILE A CA   1 
ATOM   1403 C C    . ILE A 1 94  ? 29.46796 -12.28903 4.61515  1.000 27.95337  ? 91  ILE A C    1 
ATOM   1404 O O    . ILE A 1 94  ? 30.09446 -11.54787 3.85231  1.000 26.61857  ? 91  ILE A O    1 
ATOM   1405 C CB   . ILE A 1 94  ? 27.71538 -11.27335 6.11021  1.000 32.22929  ? 91  ILE A CB   1 
ATOM   1406 C CG1  . ILE A 1 94  ? 26.25240 -10.84041 6.12573  1.000 43.31498  ? 91  ILE A CG1  1 
ATOM   1407 C CG2  . ILE A 1 94  ? 28.64190 -10.06187 6.14862  1.000 38.62741  ? 91  ILE A CG2  1 
ATOM   1408 C CD1  . ILE A 1 94  ? 25.74203 -10.45746 7.51288  1.000 39.55303  ? 91  ILE A CD1  1 
ATOM   1409 H H    . ILE A 1 94  ? 26.92652 -13.56209 5.66424  1.000 32.70798  ? 91  ILE A H    1 
ATOM   1410 H HA   . ILE A 1 94  ? 27.62241 -11.62265 4.07412  1.000 28.24544  ? 91  ILE A HA   1 
ATOM   1411 H HB   . ILE A 1 94  ? 27.89304 -11.81416 6.89562  1.000 38.63060  ? 91  ILE A HB   1 
ATOM   1412 H HG12 . ILE A 1 94  ? 26.14908 -10.06806 5.54805  1.000 51.93343  ? 91  ILE A HG12 1 
ATOM   1413 H HG13 . ILE A 1 94  ? 25.70632 -11.57324 5.80068  1.000 51.93343  ? 91  ILE A HG13 1 
ATOM   1414 H HG21 . ILE A 1 94  ? 28.43218 -9.52860  6.93126  1.000 46.30834  ? 91  ILE A HG21 1 
ATOM   1415 H HG22 . ILE A 1 94  ? 29.56103 -10.36855 6.19391  1.000 46.30834  ? 91  ILE A HG22 1 
ATOM   1416 H HG23 . ILE A 1 94  ? 28.50785 -9.53616  5.34453  1.000 46.30834  ? 91  ILE A HG23 1 
ATOM   1417 H HD11 . ILE A 1 94  ? 24.81663 -10.17542 7.44215  1.000 47.41909  ? 91  ILE A HD11 1 
ATOM   1418 H HD12 . ILE A 1 94  ? 25.80912 -11.22823 8.09796  1.000 47.41909  ? 91  ILE A HD12 1 
ATOM   1419 H HD13 . ILE A 1 94  ? 26.28365 -9.73111  7.85925  1.000 47.41909  ? 91  ILE A HD13 1 
ATOM   1420 N N    . LEU A 1 95  ? 30.07932 -13.23038 5.33781  1.000 24.94071  ? 92  LEU A N    1 
ATOM   1421 C CA   . LEU A 1 95  ? 31.50896 -13.40180 5.18028  1.000 25.41319  ? 92  LEU A CA   1 
ATOM   1422 C C    . LEU A 1 95  ? 31.85742 -13.97283 3.80089  1.000 22.75277  ? 92  LEU A C    1 
ATOM   1423 O O    . LEU A 1 95  ? 32.85518 -13.57221 3.20068  1.000 25.83444  ? 92  LEU A O    1 
ATOM   1424 C CB   . LEU A 1 95  ? 32.03792 -14.28674 6.31461  1.000 23.97308  ? 92  LEU A CB   1 
ATOM   1425 C CG   . LEU A 1 95  ? 31.96620 -13.73531 7.76627  1.000 29.05893  ? 92  LEU A CG   1 
ATOM   1426 C CD1  . LEU A 1 95  ? 32.46055 -14.80819 8.73104  1.000 30.21506  ? 92  LEU A CD1  1 
ATOM   1427 C CD2  . LEU A 1 95  ? 32.75386 -12.44725 7.89872  1.000 31.43607  ? 92  LEU A CD2  1 
ATOM   1428 H H    . LEU A 1 95  ? 29.69890 -13.75744 5.90092  1.000 29.88430  ? 92  LEU A H    1 
ATOM   1429 H HA   . LEU A 1 95  ? 31.95061 -12.54057 5.24460  1.000 30.45128  ? 92  LEU A HA   1 
ATOM   1430 H HB2  . LEU A 1 95  ? 31.52923 -15.11260 6.30519  1.000 28.72315  ? 92  LEU A HB2  1 
ATOM   1431 H HB3  . LEU A 1 95  ? 32.97277 -14.47082 6.13273  1.000 28.72315  ? 92  LEU A HB3  1 
ATOM   1432 H HG   . LEU A 1 95  ? 31.04946 -13.51715 7.99627  1.000 34.82616  ? 92  LEU A HG   1 
ATOM   1433 H HD11 . LEU A 1 95  ? 32.41923 -14.46215 9.63627  1.000 36.21352  ? 92  LEU A HD11 1 
ATOM   1434 H HD12 . LEU A 1 95  ? 31.89371 -15.59116 8.65003  1.000 36.21352  ? 92  LEU A HD12 1 
ATOM   1435 H HD13 . LEU A 1 95  ? 33.37577 -15.03770 8.50610  1.000 36.21352  ? 92  LEU A HD13 1 
ATOM   1436 H HD21 . LEU A 1 95  ? 32.67908 -12.12365 8.81009  1.000 37.67873  ? 92  LEU A HD21 1 
ATOM   1437 H HD22 . LEU A 1 95  ? 33.68371 -12.62231 7.68511  1.000 37.67873  ? 92  LEU A HD22 1 
ATOM   1438 H HD23 . LEU A 1 95  ? 32.39114 -11.79063 7.28375  1.000 37.67873  ? 92  LEU A HD23 1 
ATOM   1439 N N    A LYS A 1 96  ? 31.06437 -14.92221 3.29222  0.502 27.61065  ? 93  LYS A N    1 
ATOM   1440 N N    B LYS A 1 96  ? 31.07241 -14.93326 3.29539  0.498 27.65019  ? 93  LYS A N    1 
ATOM   1441 C CA   A LYS A 1 96  ? 31.39522 -15.46823 1.97368  0.502 29.04359  ? 93  LYS A CA   1 
ATOM   1442 C CA   B LYS A 1 96  ? 31.40561 -15.46458 1.97049  0.498 29.01845  ? 93  LYS A CA   1 
ATOM   1443 C C    A LYS A 1 96  ? 31.27411 -14.38940 0.90710  0.502 26.46172  ? 93  LYS A C    1 
ATOM   1444 C C    B LYS A 1 96  ? 31.29319 -14.37005 0.91917  0.498 26.50758  ? 93  LYS A C    1 
ATOM   1445 O O    A LYS A 1 96  ? 32.12443 -14.28953 0.01544  0.502 30.71818  ? 93  LYS A O    1 
ATOM   1446 O O    B LYS A 1 96  ? 32.15928 -14.24698 0.04457  0.498 30.62870  ? 93  LYS A O    1 
ATOM   1447 C CB   A LYS A 1 96  ? 30.51423 -16.68140 1.66058  0.502 30.63923  ? 93  LYS A CB   1 
ATOM   1448 C CB   B LYS A 1 96  ? 30.51953 -16.66288 1.61668  0.498 30.60144  ? 93  LYS A CB   1 
ATOM   1449 C CG   A LYS A 1 96  ? 30.85789 -17.88663 2.55621  0.502 42.08530  ? 93  LYS A CG   1 
ATOM   1450 C CG   B LYS A 1 96  ? 31.08317 -18.02922 2.09007  0.498 43.11262  ? 93  LYS A CG   1 
ATOM   1451 C CD   A LYS A 1 96  ? 30.25033 -19.21425 2.09791  0.502 46.52086  ? 93  LYS A CD   1 
ATOM   1452 C CD   B LYS A 1 96  ? 32.41769 -18.39553 1.40372  0.498 38.71495  ? 93  LYS A CD   1 
ATOM   1453 C CE   A LYS A 1 96  ? 30.72090 -20.38188 2.97922  0.502 45.43317  ? 93  LYS A CE   1 
ATOM   1454 C CE   B LYS A 1 96  ? 33.14939 -19.59731 2.05668  0.498 46.71338  ? 93  LYS A CE   1 
ATOM   1455 N NZ   A LYS A 1 96  ? 32.16070 -20.75859 2.80415  0.502 42.91180  ? 93  LYS A NZ   1 
ATOM   1456 N NZ   B LYS A 1 96  ? 34.59822 -19.71389 1.62475  0.498 39.55331  ? 93  LYS A NZ   1 
ATOM   1457 H HA   A LYS A 1 96  ? 32.31206 -15.78494 1.97360  0.502 34.80776  ? 93  LYS A HA   1 
ATOM   1458 H HA   B LYS A 1 96  ? 32.31907 -15.79064 1.98337  0.498 34.77759  ? 93  LYS A HA   1 
ATOM   1459 H HB2  A LYS A 1 96  ? 29.58464 -16.44746 1.80902  0.502 36.72252  ? 93  LYS A HB2  1 
ATOM   1460 H HB2  B LYS A 1 96  ? 29.65215 -16.54148 2.03359  0.498 36.67717  ? 93  LYS A HB2  1 
ATOM   1461 H HB3  A LYS A 1 96  ? 30.64715 -16.94205 0.73576  0.502 36.72252  ? 93  LYS A HB3  1 
ATOM   1462 H HB3  B LYS A 1 96  ? 30.42153 -16.70261 0.65247  0.498 36.67717  ? 93  LYS A HB3  1 
ATOM   1463 H HG2  A LYS A 1 96  ? 31.82153 -17.99647 2.57086  0.502 50.45781  ? 93  LYS A HG2  1 
ATOM   1464 H HG2  B LYS A 1 96  ? 31.23851 -17.99310 3.04687  0.498 51.69059  ? 93  LYS A HG2  1 
ATOM   1465 H HG3  A LYS A 1 96  ? 30.53047 -17.70981 3.45199  0.502 50.45781  ? 93  LYS A HG3  1 
ATOM   1466 H HG3  B LYS A 1 96  ? 30.43970 -18.72534 1.88448  0.498 51.69059  ? 93  LYS A HG3  1 
ATOM   1467 H HD2  A LYS A 1 96  ? 29.28334 -19.16116 2.15272  0.502 55.78048  ? 93  LYS A HD2  1 
ATOM   1468 H HD2  B LYS A 1 96  ? 32.24009 -18.62582 0.47835  0.498 46.41339  ? 93  LYS A HD2  1 
ATOM   1469 H HD3  A LYS A 1 96  ? 30.52149 -19.39336 1.18397  0.502 55.78048  ? 93  LYS A HD3  1 
ATOM   1470 H HD3  B LYS A 1 96  ? 33.01161 -17.62983 1.44693  0.498 46.41339  ? 93  LYS A HD3  1 
ATOM   1471 H HE2  A LYS A 1 96  ? 30.59487 -20.13699 3.90929  0.502 54.47525  ? 93  LYS A HE2  1 
ATOM   1472 H HE2  B LYS A 1 96  ? 33.13265 -19.49091 3.02068  0.498 56.01151  ? 93  LYS A HE2  1 
ATOM   1473 H HE3  A LYS A 1 96  ? 30.18735 -21.16359 2.76675  0.502 54.47525  ? 93  LYS A HE3  1 
ATOM   1474 H HE3  B LYS A 1 96  ? 32.69584 -20.41712 1.80546  0.498 56.01151  ? 93  LYS A HE3  1 
ATOM   1475 H HZ1  A LYS A 1 96  ? 32.36472 -21.43892 3.34046  0.502 51.44961  ? 93  LYS A HZ1  1 
ATOM   1476 H HZ1  B LYS A 1 96  ? 34.97854 -20.41427 2.02088  0.498 47.41942  ? 93  LYS A HZ1  1 
ATOM   1477 H HZ2  A LYS A 1 96  ? 32.31180 -21.00010 1.96098  0.502 51.44961  ? 93  LYS A HZ2  1 
ATOM   1478 H HZ2  B LYS A 1 96  ? 34.64518 -19.82041 0.74240  0.498 47.41942  ? 93  LYS A HZ2  1 
ATOM   1479 H HZ3  A LYS A 1 96  ? 32.68298 -20.06631 3.00433  0.502 51.44961  ? 93  LYS A HZ3  1 
ATOM   1480 H HZ3  B LYS A 1 96  ? 35.04348 -18.97719 1.85085  0.498 47.41942  ? 93  LYS A HZ3  1 
ATOM   1481 N N    . GLU A 1 97  ? 30.26655 -13.52049 1.02788  1.000 26.22169  ? 94  GLU A N    1 
ATOM   1482 C CA   . GLU A 1 97  ? 30.13269 -12.43396 0.07245  1.000 30.36287  ? 94  GLU A CA   1 
ATOM   1483 C C    . GLU A 1 97  ? 31.30344 -11.46828 0.17642  1.000 37.31596  ? 94  GLU A C    1 
ATOM   1484 O O    . GLU A 1 97  ? 31.81983 -10.99713 -0.84832 1.000 29.90793  ? 94  GLU A O    1 
ATOM   1485 C CB   . GLU A 1 97  ? 28.80834 -11.68641 0.27423  1.000 31.70409  ? 94  GLU A CB   1 
ATOM   1486 C CG   . GLU A 1 97  ? 28.72581 -10.43804 -0.60164 1.000 56.64808  ? 94  GLU A CG   1 
ATOM   1487 C CD   . GLU A 1 97  ? 27.46962 -9.59656  -0.37683 1.000 82.11780  ? 94  GLU A CD   1 
ATOM   1488 O OE1  . GLU A 1 97  ? 26.86772 -9.65794  0.72013  1.000 63.86276  ? 94  GLU A OE1  1 
ATOM   1489 O OE2  . GLU A 1 97  ? 27.09519 -8.85638  -1.30939 1.000 76.31308  ? 94  GLU A OE2  1 
ATOM   1490 H HA   . GLU A 1 97  ? 30.12120 -12.81406 -0.81990 1.000 36.39090  ? 94  GLU A HA   1 
ATOM   1491 H HB2  . GLU A 1 97  ? 28.07155 -12.27231 0.04022  1.000 38.00035  ? 94  GLU A HB2  1 
ATOM   1492 H HB3  . GLU A 1 97  ? 28.73337 -11.41343 1.20200  1.000 38.00035  ? 94  GLU A HB3  1 
ATOM   1493 H HG2  . GLU A 1 97  ? 29.49356 -9.87571  -0.41391 1.000 67.93315  ? 94  GLU A HG2  1 
ATOM   1494 H HG3  . GLU A 1 97  ? 28.73401 -10.71073 -1.53249 1.000 67.93315  ? 94  GLU A HG3  1 
ATOM   1495 N N    . GLN A 1 98  ? 31.72032 -11.13192 1.41093  1.000 28.91285  ? 95  GLN A N    1 
ATOM   1496 C CA   . GLN A 1 98  ? 32.84851 -10.23128 1.56916  1.000 26.58249  ? 95  GLN A CA   1 
ATOM   1497 C C    . GLN A 1 98  ? 34.12946 -10.83239 0.98504  1.000 27.38491  ? 95  GLN A C    1 
ATOM   1498 O O    . GLN A 1 98  ? 34.90071 -10.13928 0.30351  1.000 29.60063  ? 95  GLN A O    1 
ATOM   1499 C CB   . GLN A 1 98  ? 33.03391 -9.89062  3.06785  1.000 28.97972  ? 95  GLN A CB   1 
ATOM   1500 C CG   . GLN A 1 98  ? 34.04338 -8.79443  3.33107  1.000 29.07298  ? 95  GLN A CG   1 
ATOM   1501 C CD   . GLN A 1 98  ? 33.51474 -7.39829  3.01696  1.000 31.88312  ? 95  GLN A CD   1 
ATOM   1502 O OE1  . GLN A 1 98  ? 32.49925 -7.23721  2.32002  1.000 32.03657  ? 95  GLN A OE1  1 
ATOM   1503 N NE2  . GLN A 1 98  ? 34.19602 -6.39030  3.52724  1.000 26.62679  ? 95  GLN A NE2  1 
ATOM   1504 H H    . GLN A 1 98  ? 31.36991 -11.40928 2.14570  1.000 34.65087  ? 95  GLN A H    1 
ATOM   1505 H HA   . GLN A 1 98  ? 32.66681 -9.40756  1.09024  1.000 31.85444  ? 95  GLN A HA   1 
ATOM   1506 H HB2  . GLN A 1 98  ? 32.18164 -9.59927  3.42791  1.000 34.73112  ? 95  GLN A HB2  1 
ATOM   1507 H HB3  . GLN A 1 98  ? 33.33553 -10.68695 3.53239  1.000 34.73112  ? 95  GLN A HB3  1 
ATOM   1508 H HG2  . GLN A 1 98  ? 34.29145 -8.81466  4.26860  1.000 34.84302  ? 95  GLN A HG2  1 
ATOM   1509 H HG3  . GLN A 1 98  ? 34.82507 -8.94805  2.77767  1.000 34.84302  ? 95  GLN A HG3  1 
ATOM   1510 H HE21 . GLN A 1 98  ? 34.89435 -6.54174  4.00579  1.000 31.90760  ? 95  GLN A HE21 1 
ATOM   1511 H HE22 . GLN A 1 98  ? 33.94179 -5.58180  3.38133  1.000 31.90760  ? 95  GLN A HE22 1 
ATOM   1512 N N    . GLU A 1 99  ? 34.37818 -12.12181 1.23843  1.000 28.94509  ? 96  GLU A N    1 
ATOM   1513 C CA   . GLU A 1 99  ? 35.58447 -12.73542 0.69313  1.000 31.36631  ? 96  GLU A CA   1 
ATOM   1514 C C    . GLU A 1 99  ? 35.54338 -12.75166 -0.84095 1.000 32.53198  ? 96  GLU A C    1 
ATOM   1515 O O    . GLU A 1 99  ? 36.55431 -12.48082 -1.50542 1.000 32.52727  ? 96  GLU A O    1 
ATOM   1516 C CB   . GLU A 1 99  ? 35.72516 -14.15626 1.24231  1.000 35.03916  ? 96  GLU A CB   1 
ATOM   1517 C CG   . GLU A 1 99  ? 37.02402 -14.84446 0.82785  1.000 41.98843  ? 96  GLU A CG   1 
ATOM   1518 C CD   . GLU A 1 99  ? 37.17094 -16.24793 1.46027  1.000 34.58460  ? 96  GLU A CD   1 
ATOM   1519 O OE1  . GLU A 1 99  ? 36.17368 -16.97451 1.51865  1.000 40.01672  ? 96  GLU A OE1  1 
ATOM   1520 O OE2  . GLU A 1 99  ? 38.28477 -16.57718 1.87703  1.000 41.35405  ? 96  GLU A OE2  1 
ATOM   1521 H H    . GLU A 1 99  ? 33.87991 -12.64283 1.70731  1.000 34.68956  ? 96  GLU A H    1 
ATOM   1522 H HA   . GLU A 1 99  ? 36.36095 -12.22319 0.96809  1.000 37.59502  ? 96  GLU A HA   1 
ATOM   1523 H HB2  . GLU A 1 99  ? 35.70409 -14.12038 2.21141  1.000 42.00245  ? 96  GLU A HB2  1 
ATOM   1524 H HB3  . GLU A 1 99  ? 34.98678 -14.69286 0.91405  1.000 42.00245  ? 96  GLU A HB3  1 
ATOM   1525 H HG2  . GLU A 1 99  ? 37.03683 -14.94502 -0.13683 1.000 50.34156  ? 96  GLU A HG2  1 
ATOM   1526 H HG3  . GLU A 1 99  ? 37.77621 -14.30351 1.11504  1.000 50.34156  ? 96  GLU A HG3  1 
ATOM   1527 N N    . ASN A 1 100 ? 34.36695 -13.02625 -1.41518 1.000 30.71630  ? 97  ASN A N    1 
ATOM   1528 C CA   . ASN A 1 100 ? 34.24204 -13.08845 -2.87631 1.000 33.85795  ? 97  ASN A CA   1 
ATOM   1529 C C    . ASN A 1 100 ? 34.53370 -11.74654 -3.52725 1.000 38.28129  ? 97  ASN A C    1 
ATOM   1530 O O    . ASN A 1 100 ? 35.15487 -11.69599 -4.58911 1.000 40.58173  ? 97  ASN A O    1 
ATOM   1531 C CB   . ASN A 1 100 ? 32.84989 -13.55103 -3.26269 1.000 37.79571  ? 97  ASN A CB   1 
ATOM   1532 C CG   . ASN A 1 100 ? 32.69679 -15.04936 -3.16528 1.000 57.11319  ? 97  ASN A CG   1 
ATOM   1533 O OD1  . ASN A 1 100 ? 33.66169 -15.79548 -3.32617 1.000 75.00861  ? 97  ASN A OD1  1 
ATOM   1534 N ND2  . ASN A 1 100 ? 31.48147 -15.50352 -2.89906 1.000 58.32304  ? 97  ASN A ND2  1 
ATOM   1535 H H    . ASN A 1 100 ? 33.63579 -13.17844 -0.98875 1.000 36.81502  ? 97  ASN A H    1 
ATOM   1536 H HA   . ASN A 1 100 ? 34.88882 -13.73241 -3.20475 1.000 40.58499  ? 97  ASN A HA   1 
ATOM   1537 H HB2  . ASN A 1 100 ? 32.20239 -13.14207 -2.66738 1.000 45.31030  ? 97  ASN A HB2  1 
ATOM   1538 H HB3  . ASN A 1 100 ? 32.67047 -13.28817 -4.17899 1.000 45.31030  ? 97  ASN A HB3  1 
ATOM   1539 H HD21 . ASN A 1 100 ? 30.83032 -14.95209 -2.79165 1.000 69.94310  ? 97  ASN A HD21 1 
ATOM   1540 H HD22 . ASN A 1 100 ? 31.34346 -16.34985 -2.83360 1.000 69.94310  ? 97  ASN A HD22 1 
ATOM   1541 N N    . ARG A 1 101 ? 34.09326 -10.64645 -2.91691 1.000 39.26213  ? 98  ARG A N    1 
ATOM   1542 C CA   . ARG A 1 101 ? 34.33302 -9.31823  -3.46381 1.000 35.14767  ? 98  ARG A CA   1 
ATOM   1543 C C    . ARG A 1 101 ? 35.64994 -8.71216  -3.02986 1.000 36.33619  ? 98  ARG A C    1 
ATOM   1544 O O    . ARG A 1 101 ? 35.94557 -7.57680  -3.42072 1.000 40.55390  ? 98  ARG A O    1 
ATOM   1545 C CB   . ARG A 1 101 ? 33.19280 -8.36735  -3.10047 1.000 37.72424  ? 98  ARG A CB   1 
ATOM   1546 C CG   . ARG A 1 101 ? 33.04793 -8.05837  -1.62678 1.000 45.23623  ? 98  ARG A CG   1 
ATOM   1547 C CD   . ARG A 1 101 ? 31.78632 -7.22673  -1.42180 1.000 57.99174  ? 98  ARG A CD   1 
ATOM   1548 N NE   . ARG A 1 101 ? 31.97203 -5.88809  -1.96266 1.000 56.33563  ? 98  ARG A NE   1 
ATOM   1549 C CZ   . ARG A 1 101 ? 32.67570 -4.94108  -1.35290 1.000 78.50320  ? 98  ARG A CZ   1 
ATOM   1550 N NH1  . ARG A 1 101 ? 33.19436 -5.13219  -0.14296 1.000 43.07180  ? 98  ARG A NH1  1 
ATOM   1551 N NH2  . ARG A 1 101 ? 32.87339 -3.77838  -1.97181 1.000 60.09814  ? 98  ARG A NH2  1 
ATOM   1552 H H    . ARG A 1 101 ? 33.65029 -10.64700 -2.17977 1.000 47.07000  ? 98  ARG A H    1 
ATOM   1553 H HA   . ARG A 1 101 ? 34.35231 -9.40051  -4.43012 1.000 42.13265  ? 98  ARG A HA   1 
ATOM   1554 H HB2  . ARG A 1 101 ? 33.33990 -7.52532  -3.55898 1.000 45.22453  ? 98  ARG A HB2  1 
ATOM   1555 H HB3  . ARG A 1 101 ? 32.35852 -8.76452  -3.39564 1.000 45.22453  ? 98  ARG A HB3  1 
ATOM   1556 H HG2  . ARG A 1 101 ? 32.96912 -8.88248  -1.12128 1.000 54.23892  ? 98  ARG A HG2  1 
ATOM   1557 H HG3  . ARG A 1 101 ? 33.81475 -7.55135  -1.31724 1.000 54.23892  ? 98  ARG A HG3  1 
ATOM   1558 H HD2  . ARG A 1 101 ? 31.04149 -7.64612  -1.88032 1.000 69.54554  ? 98  ARG A HD2  1 
ATOM   1559 H HD3  . ARG A 1 101 ? 31.59410 -7.15448  -0.47378 1.000 69.54554  ? 98  ARG A HD3  1 
ATOM   1560 H HE   . ARG A 1 101 ? 31.60625 -5.70029  -2.71800 1.000 67.55820  ? 98  ARG A HE   1 
ATOM   1561 H HH11 . ARG A 1 101 ? 33.07705 -5.88195  0.26165  1.000 51.64161  ? 98  ARG A HH11 1 
ATOM   1562 H HH12 . ARG A 1 101 ? 33.64698 -4.50600  0.23468  1.000 51.64161  ? 98  ARG A HH12 1 
ATOM   1563 H HH21 . ARG A 1 101 ? 32.54694 -3.64810  -2.75671 1.000 72.07322  ? 98  ARG A HH21 1 
ATOM   1564 H HH22 . ARG A 1 101 ? 33.32749 -3.15793  -1.58654 1.000 72.07322  ? 98  ARG A HH22 1 
ATOM   1565 N N    . LYS A 1 102 ? 36.45668 -9.43015  -2.24346 1.000 31.68067  ? 99  LYS A N    1 
ATOM   1566 C CA   . LYS A 1 102 ? 37.78790 -8.97317  -1.88135 1.000 33.10572  ? 99  LYS A CA   1 
ATOM   1567 C C    . LYS A 1 102 ? 37.71113 -7.75327  -0.95646 1.000 35.15199  ? 99  LYS A C    1 
ATOM   1568 O O    . LYS A 1 102 ? 38.53132 -6.84046  -1.01911 1.000 38.92130  ? 99  LYS A O    1 
ATOM   1569 C CB   . LYS A 1 102 ? 38.63155 -8.72174  -3.13408 1.000 45.39445  ? 99  LYS A CB   1 
ATOM   1570 C CG   . LYS A 1 102 ? 38.77360 -10.02547 -3.95155 1.000 47.72131  ? 99  LYS A CG   1 
ATOM   1571 C CD   . LYS A 1 102 ? 39.51774 -9.85675  -5.26848 1.000 70.65986  ? 99  LYS A CD   1 
ATOM   1572 C CE   . LYS A 1 102 ? 40.98981 -9.58105  -5.04282 1.000 81.08668  ? 99  LYS A CE   1 
ATOM   1573 N NZ   . LYS A 1 102 ? 41.66662 -9.14679  -6.29501 1.000 107.00152 ? 99  LYS A NZ   1 
ATOM   1574 H H    . LYS A 1 102 ? 36.24734 -10.19321 -1.90653 1.000 37.97226  ? 99  LYS A H    1 
ATOM   1575 H HA   . LYS A 1 102 ? 38.24755 -9.65987  -1.37334 1.000 39.68231  ? 99  LYS A HA   1 
ATOM   1576 H HB2  . LYS A 1 102 ? 38.20025 -8.05246  -3.68810 1.000 54.42879  ? 99  LYS A HB2  1 
ATOM   1577 H HB3  . LYS A 1 102 ? 39.51595 -8.41861  -2.87553 1.000 54.42879  ? 99  LYS A HB3  1 
ATOM   1578 H HG2  . LYS A 1 102 ? 39.26078 -10.67442 -3.42012 1.000 57.22102  ? 99  LYS A HG2  1 
ATOM   1579 H HG3  . LYS A 1 102 ? 37.88736 -10.36251 -4.15622 1.000 57.22102  ? 99  LYS A HG3  1 
ATOM   1580 H HD2  . LYS A 1 102 ? 39.43644 -10.67056 -5.79002 1.000 84.74729  ? 99  LYS A HD2  1 
ATOM   1581 H HD3  . LYS A 1 102 ? 39.13921 -9.10978  -5.75801 1.000 84.74729  ? 99  LYS A HD3  1 
ATOM   1582 H HE2  . LYS A 1 102 ? 41.08630 -8.87530  -4.38441 1.000 97.25947  ? 99  LYS A HE2  1 
ATOM   1583 H HE3  . LYS A 1 102 ? 41.42264 -10.38999 -4.72791 1.000 97.25947  ? 99  LYS A HE3  1 
ATOM   1584 H HZ1  . LYS A 1 102 ? 42.52926 -8.99444  -6.13768 1.000 128.35728 ? 99  LYS A HZ1  1 
ATOM   1585 H HZ2  . LYS A 1 102 ? 41.59374 -9.78029  -6.91586 1.000 128.35728 ? 99  LYS A HZ2  1 
ATOM   1586 H HZ3  . LYS A 1 102 ? 41.29219 -8.39915  -6.59988 1.000 128.35728 ? 99  LYS A HZ3  1 
ATOM   1587 N N    . GLY A 1 103 ? 36.73670 -7.76887  -0.07483 1.000 31.17366  ? 100 GLY A N    1 
ATOM   1588 C CA   . GLY A 1 103 ? 36.67750 -6.80779  0.99979  1.000 27.20207  ? 100 GLY A CA   1 
ATOM   1589 C C    . GLY A 1 103 ? 37.40142 -7.30967  2.28464  1.000 24.74514  ? 100 GLY A C    1 
ATOM   1590 O O    . GLY A 1 103 ? 37.59717 -8.50156  2.48339  1.000 29.95232  ? 100 GLY A O    1 
ATOM   1591 H H    . GLY A 1 103 ? 36.08816 -8.33367  -0.07650 1.000 37.36384  ? 100 GLY A H    1 
ATOM   1592 H HA2  . GLY A 1 103 ? 37.09794 -5.98140  0.71483  1.000 32.59793  ? 100 GLY A HA2  1 
ATOM   1593 H HA3  . GLY A 1 103 ? 35.74987 -6.63029  1.22091  1.000 32.59793  ? 100 GLY A HA3  1 
ATOM   1594 N N    . LEU A 1 104 ? 37.73076 -6.35553  3.14981  1.000 27.68305  ? 101 LEU A N    1 
ATOM   1595 C CA   . LEU A 1 104 ? 38.46802 -6.67147  4.37620  1.000 25.53127  ? 101 LEU A CA   1 
ATOM   1596 C C    . LEU A 1 104 ? 37.58671 -7.38134  5.39173  1.000 23.81758  ? 101 LEU A C    1 
ATOM   1597 O O    . LEU A 1 104 ? 36.41705 -7.02923  5.59492  1.000 22.75624  ? 101 LEU A O    1 
ATOM   1598 C CB   . LEU A 1 104 ? 39.02110 -5.38785  4.98367  1.000 22.87642  ? 101 LEU A CB   1 
ATOM   1599 C CG   . LEU A 1 104 ? 39.99071 -5.44696  6.16509  1.000 33.03078  ? 101 LEU A CG   1 
ATOM   1600 C CD1  . LEU A 1 104 ? 41.28062 -6.11273  5.74578  1.000 34.29355  ? 101 LEU A CD1  1 
ATOM   1601 C CD2  . LEU A 1 104 ? 40.24548 -4.02357  6.66606  1.000 38.40867  ? 101 LEU A CD2  1 
ATOM   1602 H H    . LEU A 1 104 ? 37.54215 -5.52194  3.05414  1.000 33.17511  ? 101 LEU A H    1 
ATOM   1603 H HA   . LEU A 1 104 ? 39.20247 -7.26695  4.15965  1.000 30.59297  ? 101 LEU A HA   1 
ATOM   1604 H HB2  . LEU A 1 104 ? 39.48839 -4.91607  4.27659  1.000 27.40715  ? 101 LEU A HB2  1 
ATOM   1605 H HB3  . LEU A 1 104 ? 38.26185 -4.86518  5.28577  1.000 27.40715  ? 101 LEU A HB3  1 
ATOM   1606 H HG   . LEU A 1 104 ? 39.61414 -5.97098  6.88932  1.000 39.59239  ? 101 LEU A HG   1 
ATOM   1607 H HD11 . LEU A 1 104 ? 41.88892 -6.12664  6.50121  1.000 41.10771  ? 101 LEU A HD11 1 
ATOM   1608 H HD12 . LEU A 1 104 ? 41.08925 -7.01922  5.45845  1.000 41.10771  ? 101 LEU A HD12 1 
ATOM   1609 H HD13 . LEU A 1 104 ? 41.67248 -5.60979  5.01476  1.000 41.10771  ? 101 LEU A HD13 1 
ATOM   1610 H HD21 . LEU A 1 104 ? 40.83177 -4.06065  7.43793  1.000 46.04585  ? 101 LEU A HD21 1 
ATOM   1611 H HD22 . LEU A 1 104 ? 40.66346 -3.50951  5.95759  1.000 46.04585  ? 101 LEU A HD22 1 
ATOM   1612 H HD23 . LEU A 1 104 ? 39.39894 -3.61936  6.91280  1.000 46.04585  ? 101 LEU A HD23 1 
ATOM   1613 N N    . ILE A 1 105 ? 38.17386 -8.36757  6.07602  1.000 21.84869  ? 102 ILE A N    1 
ATOM   1614 C CA   . ILE A 1 105 ? 37.50583 -9.06499  7.16976  1.000 20.95883  ? 102 ILE A CA   1 
ATOM   1615 C C    . ILE A 1 105 ? 38.43258 -8.92745  8.36889  1.000 21.52187  ? 102 ILE A C    1 
ATOM   1616 O O    . ILE A 1 105 ? 39.63810 -9.18169  8.24088  1.000 22.67349  ? 102 ILE A O    1 
ATOM   1617 C CB   . ILE A 1 105 ? 37.24139 -10.54318 6.84174  1.000 22.72023  ? 102 ILE A CB   1 
ATOM   1618 C CG1  . ILE A 1 105 ? 36.29531 -10.64068 5.64475  1.000 25.90975  ? 102 ILE A CG1  1 
ATOM   1619 C CG2  . ILE A 1 105 ? 36.62279 -11.23084 7.98941  1.000 25.14455  ? 102 ILE A CG2  1 
ATOM   1620 C CD1  . ILE A 1 105 ? 36.02698 -12.09438 5.10400  1.000 33.21857  ? 102 ILE A CD1  1 
ATOM   1621 H H    . ILE A 1 105 ? 38.97044 -8.65157  5.91982  1.000 26.17388  ? 102 ILE A H    1 
ATOM   1622 H HA   . ILE A 1 105 ? 36.64528 -8.66249  7.36560  1.000 25.10605  ? 102 ILE A HA   1 
ATOM   1623 H HB   . ILE A 1 105 ? 38.09136 -10.96308 6.63645  1.000 27.21973  ? 102 ILE A HB   1 
ATOM   1624 H HG12 . ILE A 1 105 ? 35.43826 -10.26689 5.90291  1.000 31.04715  ? 102 ILE A HG12 1 
ATOM   1625 H HG13 . ILE A 1 105 ? 36.67464 -10.12737 4.91433  1.000 31.04715  ? 102 ILE A HG13 1 
ATOM   1626 H HG21 . ILE A 1 105 ? 36.43005 -12.14854 7.74125  1.000 30.12891  ? 102 ILE A HG21 1 
ATOM   1627 H HG22 . ILE A 1 105 ? 37.23941 -11.21315 8.73798  1.000 30.12891  ? 102 ILE A HG22 1 
ATOM   1628 H HG23 . ILE A 1 105 ? 35.80130 -10.77284 8.22665  1.000 30.12891  ? 102 ILE A HG23 1 
ATOM   1629 H HD11 . ILE A 1 105 ? 35.45621 -12.03993 4.32160  1.000 39.81773  ? 102 ILE A HD11 1 
ATOM   1630 H HD12 . ILE A 1 105 ? 36.87359 -12.50478 4.86792  1.000 39.81773  ? 102 ILE A HD12 1 
ATOM   1631 H HD13 . ILE A 1 105 ? 35.58964 -12.61339 5.79701  1.000 39.81773  ? 102 ILE A HD13 1 
ATOM   1632 N N    . ALA A 1 106 ? 37.89786 -8.47136  9.50891  1.000 21.95730  ? 103 ALA A N    1 
ATOM   1633 C CA   . ALA A 1 106 ? 38.72491 -8.14771  10.66979 1.000 21.70614  ? 103 ALA A CA   1 
ATOM   1634 C C    . ALA A 1 106 ? 38.13826 -8.82673  11.90132 1.000 21.91999  ? 103 ALA A C    1 
ATOM   1635 O O    . ALA A 1 106 ? 36.92657 -8.74021  12.14172 1.000 23.71902  ? 103 ALA A O    1 
ATOM   1636 C CB   . ALA A 1 106 ? 38.78155 -6.62167  10.90505 1.000 22.07908  ? 103 ALA A CB   1 
ATOM   1637 H H    . ALA A 1 106 ? 37.05630 -8.34227  9.63025  1.000 26.30421  ? 103 ALA A H    1 
ATOM   1638 H HA   . ALA A 1 106 ? 39.62547 -8.47777  10.52502 1.000 26.00281  ? 103 ALA A HA   1 
ATOM   1639 H HB1  . ALA A 1 106 ? 39.34955 -6.44098  11.67031 1.000 26.45034  ? 103 ALA A HB1  1 
ATOM   1640 H HB2  . ALA A 1 106 ? 39.14565 -6.19355  10.11445 1.000 26.45034  ? 103 ALA A HB2  1 
ATOM   1641 H HB3  . ALA A 1 106 ? 37.88418 -6.29476  11.07464 1.000 26.45034  ? 103 ALA A HB3  1 
ATOM   1642 N N    . ALA A 1 107 ? 38.96436 -9.55914  12.64726 1.000 21.90615  ? 104 ALA A N    1 
ATOM   1643 C CA   . ALA A 1 107 ? 38.44549 -10.32288 13.76650 1.000 15.97384  ? 104 ALA A CA   1 
ATOM   1644 C C    . ALA A 1 107 ? 39.47541 -10.36727 14.89017 1.000 20.77451  ? 104 ALA A C    1 
ATOM   1645 O O    . ALA A 1 107 ? 40.67829 -10.45472 14.64565 1.000 20.74430  ? 104 ALA A O    1 
ATOM   1646 C CB   . ALA A 1 107 ? 38.10311 -11.77523 13.38117 1.000 20.57211  ? 104 ALA A CB   1 
ATOM   1647 H H    . ALA A 1 107 ? 39.81279 -9.62520  12.52312 1.000 26.24283  ? 104 ALA A H    1 
ATOM   1648 H HA   . ALA A 1 107 ? 37.64404 -9.87327  14.07702 1.000 19.12406  ? 104 ALA A HA   1 
ATOM   1649 H HB1  . ALA A 1 107 ? 37.77011 -12.23976 14.16489 1.000 24.64199  ? 104 ALA A HB1  1 
ATOM   1650 H HB2  . ALA A 1 107 ? 37.42414 -11.76648 12.68847 1.000 24.64199  ? 104 ALA A HB2  1 
ATOM   1651 H HB3  . ALA A 1 107 ? 38.90458 -12.21228 13.05326 1.000 24.64199  ? 104 ALA A HB3  1 
ATOM   1652 N N    . ILE A 1 108 ? 38.99819 -10.31153 16.12179 1.000 19.18984  ? 105 ILE A N    1 
ATOM   1653 C CA   . ILE A 1 108 ? 39.91966 -10.18202 17.26423 1.000 17.12176  ? 105 ILE A CA   1 
ATOM   1654 C C    . ILE A 1 108 ? 39.61173 -11.19811 18.36294 1.000 19.81077  ? 105 ILE A C    1 
ATOM   1655 O O    . ILE A 1 108 ? 38.44474 -11.54238 18.61183 1.000 20.95884  ? 105 ILE A O    1 
ATOM   1656 C CB   . ILE A 1 108 ? 39.89490 -8.73339  17.78709 1.000 18.27229  ? 105 ILE A CB   1 
ATOM   1657 C CG1  . ILE A 1 108 ? 40.79759 -8.53325  19.00022 1.000 20.80008  ? 105 ILE A CG1  1 
ATOM   1658 C CG2  . ILE A 1 108 ? 38.46236 -8.31470  18.16799 1.000 18.97058  ? 105 ILE A CG2  1 
ATOM   1659 C CD1  . ILE A 1 108 ? 41.12769 -7.11727  19.27022 1.000 22.38042  ? 105 ILE A CD1  1 
ATOM   1660 H H    . ILE A 1 108 ? 38.16427 -10.34512 16.32925 1.000 22.98326  ? 105 ILE A H    1 
ATOM   1661 H HA   . ILE A 1 108 ? 40.82064 -10.38632 16.96859 1.000 20.50157  ? 105 ILE A HA   1 
ATOM   1662 H HB   . ILE A 1 108 ? 40.22796 -8.18241  17.06156 1.000 21.88220  ? 105 ILE A HB   1 
ATOM   1663 H HG12 . ILE A 1 108 ? 40.34947 -8.88744  19.78421 1.000 24.91554  ? 105 ILE A HG12 1 
ATOM   1664 H HG13 . ILE A 1 108 ? 41.63019 -9.00808  18.85113 1.000 24.91554  ? 105 ILE A HG13 1 
ATOM   1665 H HG21 . ILE A 1 108 ? 38.47787 -7.40445  18.50281 1.000 22.72014  ? 105 ILE A HG21 1 
ATOM   1666 H HG22 . ILE A 1 108 ? 37.89793 -8.36806  17.38092 1.000 22.72014  ? 105 ILE A HG22 1 
ATOM   1667 H HG23 . ILE A 1 108 ? 38.13016 -8.91406  18.85451 1.000 22.72014  ? 105 ILE A HG23 1 
ATOM   1668 H HD11 . ILE A 1 108 ? 41.74081 -7.07347  20.02060 1.000 26.81195  ? 105 ILE A HD11 1 
ATOM   1669 H HD12 . ILE A 1 108 ? 41.54218 -6.73370  18.48157 1.000 26.81195  ? 105 ILE A HD12 1 
ATOM   1670 H HD13 . ILE A 1 108 ? 40.31155 -6.63748  19.48148 1.000 26.81195  ? 105 ILE A HD13 1 
HETATM 1671 N N    . CSO A 1 109 ? 40.68539 -11.71415 19.00959 1.000 17.65034  ? 106 CSO A N    1 
HETATM 1672 C CA   . CSO A 1 109 ? 40.58618 -12.49730 20.27529 1.000 19.46087  ? 106 CSO A CA   1 
HETATM 1673 C CB   . CSO A 1 109 ? 39.76177 -11.69700 21.27194 1.000 19.70381  ? 106 CSO A CB   1 
HETATM 1674 S SG   . CSO A 1 109 ? 39.97954 -12.41259 22.93630 1.000 25.50274  ? 106 CSO A SG   1 
HETATM 1675 C C    . CSO A 1 109 ? 40.02489 -13.88887 19.95183 1.000 19.90652  ? 106 CSO A C    1 
HETATM 1676 O O    . CSO A 1 109 ? 40.71897 -14.69047 19.27045 1.000 20.44228  ? 106 CSO A O    1 
HETATM 1677 O OD   . CSO A 1 109 ? 38.34429 -12.68497 23.55798 1.000 22.13380  ? 106 CSO A OD   1 
HETATM 1678 H H    . CSO A 1 109 ? 41.16470 -12.17098 18.41488 1.000 21.13586  ? 106 CSO A H    1 
HETATM 1679 H HA   . CSO A 1 109 ? 41.44981 -12.65054 20.71240 1.000 23.30850  ? 106 CSO A HA   1 
HETATM 1680 H HB2  . CSO A 1 109 ? 40.06165 -10.77460 21.28433 1.000 23.60002  ? 106 CSO A HB2  1 
HETATM 1681 H HB3  . CSO A 1 109 ? 38.82264 -11.73735 21.03252 1.000 23.60002  ? 106 CSO A HB3  1 
HETATM 1682 H HD   . CSO A 1 109 ? 38.38246 -12.93070 24.49556 1.000 26.51601  ? 106 CSO A HD   1 
ATOM   1683 N N    . ALA A 1 110 ? 38.79151 -14.20681 20.37481 1.000 18.58321  ? 107 ALA A N    1 
ATOM   1684 C CA   . ALA A 1 110 ? 38.11599 -15.46129 19.94955 1.000 19.16564  ? 107 ALA A CA   1 
ATOM   1685 C C    . ALA A 1 110 ? 37.43685 -15.34141 18.58539 1.000 21.60696  ? 107 ALA A C    1 
ATOM   1686 O O    . ALA A 1 110 ? 37.06284 -16.34309 17.96327 1.000 22.39500  ? 107 ALA A O    1 
ATOM   1687 C CB   . ALA A 1 110 ? 37.08417 -15.88259 20.99459 1.000 23.69181  ? 107 ALA A CB   1 
ATOM   1688 H H    . ALA A 1 110 ? 38.32139 -13.72018 20.90563 1.000 22.25530  ? 107 ALA A H    1 
ATOM   1689 H HA   . ALA A 1 110 ? 38.79939 -16.14518 19.87109 1.000 22.95421  ? 107 ALA A HA   1 
ATOM   1690 H HB1  . ALA A 1 110 ? 36.70372 -16.73667 20.73634 1.000 28.38563  ? 107 ALA A HB1  1 
ATOM   1691 H HB2  . ALA A 1 110 ? 37.52209 -15.96258 21.85641 1.000 28.38563  ? 107 ALA A HB2  1 
ATOM   1692 H HB3  . ALA A 1 110 ? 36.38688 -15.20975 21.03907 1.000 28.38563  ? 107 ALA A HB3  1 
ATOM   1693 N N    . GLY A 1 111 ? 37.24293 -14.10434 18.11571 1.000 18.52665  ? 108 GLY A N    1 
ATOM   1694 C CA   . GLY A 1 111 ? 36.50108 -13.84577 16.90070 1.000 21.11696  ? 108 GLY A CA   1 
ATOM   1695 C C    . GLY A 1 111 ? 36.97609 -14.60718 15.68432 1.000 23.54673  ? 108 GLY A C    1 
ATOM   1696 O O    . GLY A 1 111 ? 36.15195 -15.02254 14.85450 1.000 20.97715  ? 108 GLY A O    1 
ATOM   1697 H H    . GLY A 1 111 ? 37.54011 -13.39277 18.49643 1.000 22.18743  ? 108 GLY A H    1 
ATOM   1698 H HA2  . GLY A 1 111 ? 35.57150 -14.07922 17.05001 1.000 25.29580  ? 108 GLY A HA2  1 
ATOM   1699 H HA3  . GLY A 1 111 ? 36.56024 -12.89915 16.69745 1.000 25.29580  ? 108 GLY A HA3  1 
ATOM   1700 N N    . PRO A 1 112 ? 38.28235 -14.80381 15.50790 1.000 20.18217  ? 109 PRO A N    1 
ATOM   1701 C CA   . PRO A 1 112 ? 38.73804 -15.50748 14.29474 1.000 19.51809  ? 109 PRO A CA   1 
ATOM   1702 C C    . PRO A 1 112 ? 38.24645 -16.94704 14.23357 1.000 18.18419  ? 109 PRO A C    1 
ATOM   1703 O O    . PRO A 1 112 ? 38.23015 -17.51576 13.12165 1.000 22.09452  ? 109 PRO A O    1 
ATOM   1704 C CB   . PRO A 1 112 ? 40.28301 -15.43874 14.39098 1.000 22.34965  ? 109 PRO A CB   1 
ATOM   1705 C CG   . PRO A 1 112 ? 40.53463 -14.21613 15.27439 1.000 21.60332  ? 109 PRO A CG   1 
ATOM   1706 C CD   . PRO A 1 112 ? 39.40090 -14.18005 16.25101 1.000 19.53798  ? 109 PRO A CD   1 
ATOM   1707 H HA   . PRO A 1 112 ? 38.45762 -15.03028 13.49816 1.000 23.37716  ? 109 PRO A HA   1 
ATOM   1708 H HB2  . PRO A 1 112 ? 40.63015 -16.24660 14.80055 1.000 26.77503  ? 109 PRO A HB2  1 
ATOM   1709 H HB3  . PRO A 1 112 ? 40.66944 -15.32147 13.50903 1.000 26.77503  ? 109 PRO A HB3  1 
ATOM   1710 H HG2  . PRO A 1 112 ? 41.38253 -14.31396 15.73526 1.000 25.87943  ? 109 PRO A HG2  1 
ATOM   1711 H HG3  . PRO A 1 112 ? 40.54417 -13.41418 14.72879 1.000 25.87943  ? 109 PRO A HG3  1 
ATOM   1712 H HD2  . PRO A 1 112 ? 39.61477 -14.69338 17.04577 1.000 23.40103  ? 109 PRO A HD2  1 
ATOM   1713 H HD3  . PRO A 1 112 ? 39.18522 -13.26619 16.49439 1.000 23.40103  ? 109 PRO A HD3  1 
ATOM   1714 N N    . THR A 1 113 ? 37.84651 -17.56490 15.36332 1.000 18.49776  ? 110 THR A N    1 
ATOM   1715 C CA   . THR A 1 113 ? 37.37756 -18.95406 15.26050 1.000 22.22164  ? 110 THR A CA   1 
ATOM   1716 C C    . THR A 1 113 ? 36.10126 -19.05140 14.42329 1.000 26.37486  ? 110 THR A C    1 
ATOM   1717 O O    . THR A 1 113 ? 35.81032 -20.12316 13.90641 1.000 25.23359  ? 110 THR A O    1 
ATOM   1718 C CB   . THR A 1 113 ? 37.13666 -19.58876 16.61857 1.000 24.05713  ? 110 THR A CB   1 
ATOM   1719 O OG1  . THR A 1 113 ? 36.09343 -18.89232 17.35328 1.000 24.65680  ? 110 THR A OG1  1 
ATOM   1720 C CG2  . THR A 1 113 ? 38.42067 -19.59703 17.43722 1.000 26.77124  ? 110 THR A CG2  1 
ATOM   1721 H H    . THR A 1 113 ? 37.83886 -17.21999 16.15109 1.000 22.15276  ? 110 THR A H    1 
ATOM   1722 H HA   . THR A 1 113 ? 38.08554 -19.46742 14.84082 1.000 26.62141  ? 110 THR A HA   1 
ATOM   1723 H HB   . THR A 1 113 ? 36.84577 -20.50388 16.48133 1.000 28.82400  ? 110 THR A HB   1 
ATOM   1724 H HG1  . THR A 1 113 ? 36.00996 -19.22610 18.11958 1.000 29.54361  ? 110 THR A HG1  1 
ATOM   1725 H HG21 . THR A 1 113 ? 38.27150 -20.04648 18.28376 1.000 32.08094  ? 110 THR A HG21 1 
ATOM   1726 H HG22 . THR A 1 113 ? 39.12013 -20.06261 16.95257 1.000 32.08094  ? 110 THR A HG22 1 
ATOM   1727 H HG23 . THR A 1 113 ? 38.70958 -18.68739 17.61037 1.000 32.08094  ? 110 THR A HG23 1 
ATOM   1728 N N    . ALA A 1 114 ? 35.33796 -17.95729 14.27107 1.000 22.00235  ? 111 ALA A N    1 
ATOM   1729 C CA   . ALA A 1 114 ? 34.20360 -17.95577 13.34459 1.000 23.37564  ? 111 ALA A CA   1 
ATOM   1730 C C    . ALA A 1 114 ? 34.64507 -18.03651 11.87731 1.000 26.66258  ? 111 ALA A C    1 
ATOM   1731 O O    . ALA A 1 114 ? 33.85670 -18.48554 11.01817 1.000 27.51065  ? 111 ALA A O    1 
ATOM   1732 C CB   . ALA A 1 114 ? 33.34503 -16.71177 13.56693 1.000 28.27403  ? 111 ALA A CB   1 
ATOM   1733 H H    . ALA A 1 114 ? 35.45646 -17.21456 14.68811 1.000 26.35827  ? 111 ALA A H    1 
ATOM   1734 H HA   . ALA A 1 114 ? 33.66236 -18.73889 13.53079 1.000 28.00622  ? 111 ALA A HA   1 
ATOM   1735 H HB1  . ALA A 1 114 ? 32.63285 -16.69777 12.90852 1.000 33.88429  ? 111 ALA A HB1  1 
ATOM   1736 H HB2  . ALA A 1 114 ? 32.96887 -16.74325 14.46046 1.000 33.88429  ? 111 ALA A HB2  1 
ATOM   1737 H HB3  . ALA A 1 114 ? 33.90097 -15.92286 13.46968 1.000 33.88429  ? 111 ALA A HB3  1 
ATOM   1738 N N    . LEU A 1 115 ? 35.86894 -17.58253 11.54589 1.000 23.19240  ? 112 LEU A N    1 
ATOM   1739 C CA   . LEU A 1 115 ? 36.36574 -17.76762 10.18139 1.000 22.41623  ? 112 LEU A CA   1 
ATOM   1740 C C    . LEU A 1 115 ? 36.52807 -19.24814 9.86340  1.000 27.94583  ? 112 LEU A C    1 
ATOM   1741 O O    . LEU A 1 115 ? 36.20391 -19.69987 8.75759  1.000 25.21210  ? 112 LEU A O    1 
ATOM   1742 C CB   . LEU A 1 115 ? 37.68536 -17.03106 9.96030  1.000 21.65654  ? 112 LEU A CB   1 
ATOM   1743 C CG   . LEU A 1 115 ? 37.71886 -15.51291 10.24634 1.000 26.29787  ? 112 LEU A CG   1 
ATOM   1744 C CD1  . LEU A 1 115 ? 39.08967 -14.91665 9.89322  1.000 33.35658  ? 112 LEU A CD1  1 
ATOM   1745 C CD2  . LEU A 1 115 ? 36.60016 -14.78340 9.52214  1.000 32.02874  ? 112 LEU A CD2  1 
ATOM   1746 H H    . LEU A 1 115 ? 36.40937 -17.17808 12.07876 1.000 27.78633  ? 112 LEU A H    1 
ATOM   1747 H HA   . LEU A 1 115 ? 35.71874 -17.38052 9.57111  1.000 26.85493  ? 112 LEU A HA   1 
ATOM   1748 H HB2  . LEU A 1 115 ? 38.35130 -17.43875 10.53581 1.000 25.94330  ? 112 LEU A HB2  1 
ATOM   1749 H HB3  . LEU A 1 115 ? 37.93561 -17.14590 9.03020  1.000 25.94330  ? 112 LEU A HB3  1 
ATOM   1750 H HG   . LEU A 1 115 ? 37.57615 -15.38091 11.19666 1.000 31.51289  ? 112 LEU A HG   1 
ATOM   1751 H HD11 . LEU A 1 115 ? 39.07353 -13.96262 10.06781 1.000 39.98334  ? 112 LEU A HD11 1 
ATOM   1752 H HD12 . LEU A 1 115 ? 39.76912 -15.34149 10.43981 1.000 39.98334  ? 112 LEU A HD12 1 
ATOM   1753 H HD13 . LEU A 1 115 ? 39.27187 -15.07806 8.95426  1.000 39.98334  ? 112 LEU A HD13 1 
ATOM   1754 H HD21 . LEU A 1 115 ? 36.64676 -13.83907 9.73891  1.000 38.38994  ? 112 LEU A HD21 1 
ATOM   1755 H HD22 . LEU A 1 115 ? 36.70802 -14.90910 8.56639  1.000 38.38994  ? 112 LEU A HD22 1 
ATOM   1756 H HD23 . LEU A 1 115 ? 35.74808 -15.14709 9.80953  1.000 38.38994  ? 112 LEU A HD23 1 
ATOM   1757 N N    . LEU A 1 116 ? 37.01029 -20.01416 10.82530 1.000 23.47345  ? 113 LEU A N    1 
ATOM   1758 C CA   . LEU A 1 116 ? 37.17248 -21.44921 10.62485 1.000 22.23618  ? 113 LEU A CA   1 
ATOM   1759 C C    . LEU A 1 116 ? 35.81897 -22.11562 10.44705 1.000 26.71084  ? 113 LEU A C    1 
ATOM   1760 O O    . LEU A 1 116 ? 35.62477 -22.94164 9.53558  1.000 24.76217  ? 113 LEU A O    1 
ATOM   1761 C CB   . LEU A 1 116 ? 37.91872 -22.07551 11.81881 1.000 25.63231  ? 113 LEU A CB   1 
ATOM   1762 C CG   . LEU A 1 116 ? 37.99291 -23.61404 11.81754 1.000 27.36515  ? 113 LEU A CG   1 
ATOM   1763 C CD1  . LEU A 1 116 ? 38.80121 -24.11526 10.62677 1.000 26.43103  ? 113 LEU A CD1  1 
ATOM   1764 C CD2  . LEU A 1 116 ? 38.59913 -24.06226 13.14757 1.000 33.30360  ? 113 LEU A CD2  1 
ATOM   1765 H H    . LEU A 1 116 ? 37.25148 -19.73381 11.60172 1.000 28.12359  ? 113 LEU A H    1 
ATOM   1766 H HA   . LEU A 1 116 ? 37.70476 -21.59613 9.82735  1.000 26.63886  ? 113 LEU A HA   1 
ATOM   1767 H HB2  . LEU A 1 116 ? 38.82937 -21.74142 11.81831 1.000 30.71422  ? 113 LEU A HB2  1 
ATOM   1768 H HB3  . LEU A 1 116 ? 37.46755 -21.80775 12.63468 1.000 30.71422  ? 113 LEU A HB3  1 
ATOM   1769 H HG   . LEU A 1 116 ? 37.10907 -24.00345 11.72755 1.000 32.79363  ? 113 LEU A HG   1 
ATOM   1770 H HD11 . LEU A 1 116 ? 38.82989 -25.08456 10.65006 1.000 31.67269  ? 113 LEU A HD11 1 
ATOM   1771 H HD12 . LEU A 1 116 ? 38.37558 -23.81652 9.80793  1.000 31.67269  ? 113 LEU A HD12 1 
ATOM   1772 H HD13 . LEU A 1 116 ? 39.70065 -23.75630 10.68205 1.000 31.67269  ? 113 LEU A HD13 1 
ATOM   1773 H HD21 . LEU A 1 116 ? 38.64205 -25.03116 13.16449 1.000 39.91977  ? 113 LEU A HD21 1 
ATOM   1774 H HD22 . LEU A 1 116 ? 39.49117 -23.69016 13.22938 1.000 39.91977  ? 113 LEU A HD22 1 
ATOM   1775 H HD23 . LEU A 1 116 ? 38.03982 -23.74321 13.87303 1.000 39.91977  ? 113 LEU A HD23 1 
ATOM   1776 N N    . ALA A 1 117 ? 34.86062 -21.76593 11.31367 1.000 24.77262  ? 114 ALA A N    1 
ATOM   1777 C CA   . ALA A 1 117 ? 33.55000 -22.38165 11.23103 1.000 22.69805  ? 114 ALA A CA   1 
ATOM   1778 C C    . ALA A 1 117 ? 32.91053 -22.18393 9.86877  1.000 29.19580  ? 114 ALA A C    1 
ATOM   1779 O O    . ALA A 1 117 ? 32.18940 -23.06299 9.37947  1.000 31.43074  ? 114 ALA A O    1 
ATOM   1780 C CB   . ALA A 1 117 ? 32.63563 -21.80621 12.33084 1.000 27.60001  ? 114 ALA A CB   1 
ATOM   1781 H H    . ALA A 1 117 ? 34.94953 -21.18625 11.94269 1.000 29.68259  ? 114 ALA A H    1 
ATOM   1782 H HA   . ALA A 1 117 ? 33.65331 -23.33570 11.37250 1.000 27.19311  ? 114 ALA A HA   1 
ATOM   1783 H HB1  . ALA A 1 117 ? 31.76458 -22.22871 12.27040 1.000 33.07546  ? 114 ALA A HB1  1 
ATOM   1784 H HB2  . ALA A 1 117 ? 33.03170 -21.98733 13.19757 1.000 33.07546  ? 114 ALA A HB2  1 
ATOM   1785 H HB3  . ALA A 1 117 ? 32.54872 -20.84895 12.20041 1.000 33.07546  ? 114 ALA A HB3  1 
ATOM   1786 N N    . HIS A 1 118 ? 33.14061 -21.03639 9.25660  1.000 25.67918  ? 115 HIS A N    1 
ATOM   1787 C CA   . HIS A 1 118 ? 32.51846 -20.70347 7.99134  1.000 26.14971  ? 115 HIS A CA   1 
ATOM   1788 C C    . HIS A 1 118 ? 33.44040 -20.88220 6.80008  1.000 29.19561  ? 115 HIS A C    1 
ATOM   1789 O O    . HIS A 1 118 ? 33.10989 -20.42102 5.69878  1.000 29.26210  ? 115 HIS A O    1 
ATOM   1790 C CB   . HIS A 1 118 ? 32.01694 -19.27242 8.03774  1.000 27.78730  ? 115 HIS A CB   1 
ATOM   1791 C CG   . HIS A 1 118 ? 30.97336 -19.06017 9.08532  1.000 31.79838  ? 115 HIS A CG   1 
ATOM   1792 N ND1  . HIS A 1 118 ? 29.88702 -19.89992 9.22629  1.000 27.95495  ? 115 HIS A ND1  1 
ATOM   1793 C CD2  . HIS A 1 118 ? 30.85117 -18.12048 10.04994 1.000 27.31286  ? 115 HIS A CD2  1 
ATOM   1794 C CE1  . HIS A 1 118 ? 29.13052 -19.47530 10.21931 1.000 30.76533  ? 115 HIS A CE1  1 
ATOM   1795 N NE2  . HIS A 1 118 ? 29.68571 -18.38489 10.72353 1.000 24.77082  ? 115 HIS A NE2  1 
ATOM   1796 H H    . HIS A 1 118 ? 33.66264 -20.42419 9.56040  1.000 30.77047  ? 115 HIS A H    1 
ATOM   1797 H HA   . HIS A 1 118 ? 31.76315 -21.29752 7.85900  1.000 31.33510  ? 115 HIS A HA   1 
ATOM   1798 H HB2  . HIS A 1 118 ? 32.76215 -18.68273 8.23226  1.000 33.30021  ? 115 HIS A HB2  1 
ATOM   1799 H HB3  . HIS A 1 118 ? 31.62989 -19.04534 7.17779  1.000 33.30021  ? 115 HIS A HB3  1 
ATOM   1800 H HD2  . HIS A 1 118 ? 31.44498 -17.42619 10.22386 1.000 32.73088  ? 115 HIS A HD2  1 
ATOM   1801 H HE1  . HIS A 1 118 ? 28.34332 -19.87310 10.51422 1.000 36.87384  ? 115 HIS A HE1  1 
ATOM   1802 H HE2  . HIS A 1 118 ? 29.36665 -17.91662 11.37046 1.000 29.68043  ? 115 HIS A HE2  1 
ATOM   1803 N N    . GLU A 1 119 ? 34.60165 -21.49010 7.01370  1.000 27.10140  ? 116 GLU A N    1 
ATOM   1804 C CA   . GLU A 1 119 ? 35.55074 -21.82636 5.95187  1.000 27.43839  ? 116 GLU A CA   1 
ATOM   1805 C C    . GLU A 1 119 ? 36.01967 -20.60787 5.17317  1.000 29.52008  ? 116 GLU A C    1 
ATOM   1806 O O    . GLU A 1 119 ? 36.04891 -20.60543 3.93574  1.000 30.01971  ? 116 GLU A O    1 
ATOM   1807 C CB   . GLU A 1 119 ? 34.92920 -22.87685 4.99872  1.000 30.01065  ? 116 GLU A CB   1 
ATOM   1808 C CG   . GLU A 1 119 ? 34.59424 -24.15104 5.71673  1.000 37.52522  ? 116 GLU A CG   1 
ATOM   1809 C CD   . GLU A 1 119 ? 34.22692 -25.29876 4.77395  1.000 59.89297  ? 116 GLU A CD   1 
ATOM   1810 O OE1  . GLU A 1 119 ? 34.07452 -25.07177 3.55911  1.000 51.37552  ? 116 GLU A OE1  1 
ATOM   1811 O OE2  . GLU A 1 119 ? 34.09942 -26.41903 5.27936  1.000 55.87344  ? 116 GLU A OE2  1 
ATOM   1812 H H    . GLU A 1 119 ? 34.87540 -21.72812 7.79345  1.000 32.47712  ? 116 GLU A H    1 
ATOM   1813 H HA   . GLU A 1 119 ? 36.34227 -22.19810 6.37164  1.000 32.88152  ? 116 GLU A HA   1 
ATOM   1814 H HB2  . GLU A 1 119 ? 34.11247 -22.51848 4.61738  1.000 35.96823  ? 116 GLU A HB2  1 
ATOM   1815 H HB3  . GLU A 1 119 ? 35.56246 -23.08230 4.29326  1.000 35.96823  ? 116 GLU A HB3  1 
ATOM   1816 H HG2  . GLU A 1 119 ? 35.36335 -24.42899 6.23837  1.000 44.98572  ? 116 GLU A HG2  1 
ATOM   1817 H HG3  . GLU A 1 119 ? 33.83671 -23.99216 6.30137  1.000 44.98572  ? 116 GLU A HG3  1 
ATOM   1818 N N    . ILE A 1 120 ? 36.42289 -19.55290 5.90861  1.000 23.10484  ? 117 ILE A N    1 
ATOM   1819 C CA   . ILE A 1 120 ? 36.87621 -18.30260 5.30554  1.000 23.07897  ? 117 ILE A CA   1 
ATOM   1820 C C    . ILE A 1 120 ? 38.38549 -18.20064 5.37444  1.000 27.74109  ? 117 ILE A C    1 
ATOM   1821 O O    . ILE A 1 120 ? 38.98193 -18.38976 6.42907  1.000 30.34012  ? 117 ILE A O    1 
ATOM   1822 C CB   . ILE A 1 120 ? 36.25067 -17.09055 6.04180  1.000 25.67443  ? 117 ILE A CB   1 
ATOM   1823 C CG1  . ILE A 1 120 ? 34.74331 -17.19853 6.09031  1.000 30.40687  ? 117 ILE A CG1  1 
ATOM   1824 C CG2  . ILE A 1 120 ? 36.70834 -15.77736 5.38901  1.000 26.63093  ? 117 ILE A CG2  1 
ATOM   1825 C CD1  . ILE A 1 120 ? 34.07119 -17.03509 4.74879  1.000 30.40409  ? 117 ILE A CD1  1 
ATOM   1826 H H    . ILE A 1 120 ? 36.43949 -19.54674 6.76843  1.000 27.68126  ? 117 ILE A H    1 
ATOM   1827 H HA   . ILE A 1 120 ? 36.61209 -18.30735 4.37220  1.000 27.65022  ? 117 ILE A HA   1 
ATOM   1828 H HB   . ILE A 1 120 ? 36.56405 -17.09514 6.95977  1.000 30.76476  ? 117 ILE A HB   1 
ATOM   1829 H HG12 . ILE A 1 120 ? 34.50541 -18.07364 6.43451  1.000 36.44370  ? 117 ILE A HG12 1 
ATOM   1830 H HG13 . ILE A 1 120 ? 34.40099 -16.50668 6.67773  1.000 36.44370  ? 117 ILE A HG13 1 
ATOM   1831 H HG21 . ILE A 1 120 ? 36.28384 -15.03355 5.84449  1.000 31.91256  ? 117 ILE A HG21 1 
ATOM   1832 H HG22 . ILE A 1 120 ? 37.67260 -15.70564 5.46614  1.000 31.91256  ? 117 ILE A HG22 1 
ATOM   1833 H HG23 . ILE A 1 120 ? 36.45082 -15.78304 4.45384  1.000 31.91256  ? 117 ILE A HG23 1 
ATOM   1834 H HD11 . ILE A 1 120 ? 33.11174 -17.11939 4.86391  1.000 36.44035  ? 117 ILE A HD11 1 
ATOM   1835 H HD12 . ILE A 1 120 ? 34.28587 -16.15874 4.39268  1.000 36.44035  ? 117 ILE A HD12 1 
ATOM   1836 H HD13 . ILE A 1 120 ? 34.39406 -17.72456 4.14772  1.000 36.44035  ? 117 ILE A HD13 1 
ATOM   1837 N N    . GLY A 1 121 ? 38.99002 -17.79974 4.27665  1.000 25.04838  ? 118 GLY A N    1 
ATOM   1838 C CA   . GLY A 1 121 ? 40.40253 -17.45360 4.24427  1.000 28.31421  ? 118 GLY A CA   1 
ATOM   1839 C C    . GLY A 1 121 ? 41.37721 -18.57647 4.54931  1.000 26.03226  ? 118 GLY A C    1 
ATOM   1840 O O    . GLY A 1 121 ? 42.49020 -18.29541 5.00922  1.000 24.94986  ? 118 GLY A O    1 
ATOM   1841 H H    . GLY A 1 121 ? 38.59993 -17.71561 3.51484  1.000 30.01350  ? 118 GLY A H    1 
ATOM   1842 H HA2  . GLY A 1 121 ? 40.61456 -17.11911 3.35880  1.000 33.93250  ? 118 GLY A HA2  1 
ATOM   1843 H HA3  . GLY A 1 121 ? 40.55932 -16.75015 4.89349  1.000 33.93250  ? 118 GLY A HA3  1 
ATOM   1844 N N    . PHE A 1 122 ? 41.00913 -19.82940 4.28947  1.000 26.38378  ? 119 PHE A N    1 
ATOM   1845 C CA   . PHE A 1 122 ? 41.96126 -20.92737 4.46570  1.000 21.63658  ? 119 PHE A CA   1 
ATOM   1846 C C    . PHE A 1 122 ? 43.27319 -20.62050 3.72959  1.000 25.22518  ? 119 PHE A C    1 
ATOM   1847 O O    . PHE A 1 122 ? 43.27674 -20.09365 2.61619  1.000 25.64726  ? 119 PHE A O    1 
ATOM   1848 C CB   . PHE A 1 122 ? 41.38679 -22.26891 3.98394  1.000 23.17941  ? 119 PHE A CB   1 
ATOM   1849 C CG   . PHE A 1 122 ? 40.39249 -22.90109 4.92418  1.000 26.13349  ? 119 PHE A CG   1 
ATOM   1850 C CD1  . PHE A 1 122 ? 39.92538 -22.21894 6.03911  1.000 26.42017  ? 119 PHE A CD1  1 
ATOM   1851 C CD2  . PHE A 1 122 ? 39.89076 -24.18631 4.68740  1.000 26.65148  ? 119 PHE A CD2  1 
ATOM   1852 C CE1  . PHE A 1 122 ? 38.99309 -22.78766 6.87889  1.000 29.84928  ? 119 PHE A CE1  1 
ATOM   1853 C CE2  . PHE A 1 122 ? 38.96130 -24.74575 5.53187  1.000 29.06661  ? 119 PHE A CE2  1 
ATOM   1854 C CZ   . PHE A 1 122 ? 38.52033 -24.05826 6.63378  1.000 27.37301  ? 119 PHE A CZ   1 
ATOM   1855 H H    . PHE A 1 122 ? 40.22961 -20.06762 4.01523  1.000 31.61599  ? 119 PHE A H    1 
ATOM   1856 H HA   . PHE A 1 122 ? 42.14282 -21.02264 5.41378  1.000 25.91935  ? 119 PHE A HA   1 
ATOM   1857 H HB2  . PHE A 1 122 ? 40.93718 -22.12535 3.13650  1.000 27.77074  ? 119 PHE A HB2  1 
ATOM   1858 H HB3  . PHE A 1 122 ? 42.11909 -22.89458 3.86916  1.000 27.77074  ? 119 PHE A HB3  1 
ATOM   1859 H HD1  . PHE A 1 122 ? 40.24647 -21.36548 6.22189  1.000 31.65965  ? 119 PHE A HD1  1 
ATOM   1860 H HD2  . PHE A 1 122 ? 40.18980 -24.66753 3.94990  1.000 31.93723  ? 119 PHE A HD2  1 
ATOM   1861 H HE1  . PHE A 1 122 ? 38.68144 -22.31173 7.61460  1.000 35.77459  ? 119 PHE A HE1  1 
ATOM   1862 H HE2  . PHE A 1 122 ? 38.62925 -25.59621 5.35478  1.000 34.83539  ? 119 PHE A HE2  1 
ATOM   1863 H HZ   . PHE A 1 122 ? 37.90535 -24.44784 7.21250  1.000 32.80307  ? 119 PHE A HZ   1 
ATOM   1864 N N    . GLY A 1 123 ? 44.39818 -20.92273 4.38322  1.000 22.11004  ? 120 GLY A N    1 
ATOM   1865 C CA   . GLY A 1 123 ? 45.71988 -20.65536 3.85147  1.000 22.94431  ? 120 GLY A CA   1 
ATOM   1866 C C    . GLY A 1 123 ? 46.37662 -19.39078 4.32577  1.000 26.15141  ? 120 GLY A C    1 
ATOM   1867 O O    . GLY A 1 123 ? 47.54961 -19.17143 4.03035  1.000 29.56679  ? 120 GLY A O    1 
ATOM   1868 H H    . GLY A 1 123 ? 44.41400 -21.29401 5.15878  1.000 26.48750  ? 120 GLY A H    1 
ATOM   1869 H HA2  . GLY A 1 123 ? 46.30165 -21.39328 4.09213  1.000 27.48863  ? 120 GLY A HA2  1 
ATOM   1870 H HA3  . GLY A 1 123 ? 45.65654 -20.60543 2.88483  1.000 27.48863  ? 120 GLY A HA3  1 
ATOM   1871 N N    . SER A 1 124 ? 45.67053 -18.57715 5.09788  1.000 22.18354  ? 121 SER A N    1 
ATOM   1872 C CA   . SER A 1 124 ? 46.14022 -17.30610 5.62030  1.000 18.09729  ? 121 SER A CA   1 
ATOM   1873 C C    . SER A 1 124 ? 46.88676 -17.48504 6.91573  1.000 26.70261  ? 121 SER A C    1 
ATOM   1874 O O    . SER A 1 124 ? 46.63466 -18.43226 7.67391  1.000 25.36920  ? 121 SER A O    1 
ATOM   1875 C CB   . SER A 1 124 ? 44.94835 -16.38291 5.91836  1.000 22.21966  ? 121 SER A CB   1 
ATOM   1876 O OG   . SER A 1 124 ? 44.22095 -16.07632 4.73222  1.000 31.83205  ? 121 SER A OG   1 
ATOM   1877 H H    . SER A 1 124 ? 44.86632 -18.75075 5.34830  1.000 26.57570  ? 121 SER A H    1 
ATOM   1878 H HA   . SER A 1 124 ? 46.72730 -16.91033 4.95727  1.000 21.67220  ? 121 SER A HA   1 
ATOM   1879 H HB2  . SER A 1 124 ? 44.35543 -16.82797 6.54387  1.000 26.61904  ? 121 SER A HB2  1 
ATOM   1880 H HB3  . SER A 1 124 ? 45.27983 -15.55753 6.30536  1.000 26.61904  ? 121 SER A HB3  1 
ATOM   1881 H HG   . SER A 1 124 ? 43.59978 -15.53856 4.90705  1.000 38.15391  ? 121 SER A HG   1 
ATOM   1882 N N    . LYS A 1 125 ? 47.75507 -16.52540 7.18117  1.000 22.27180  ? 122 LYS A N    1 
ATOM   1883 C CA   . LYS A 1 125 ? 48.38403 -16.37378 8.48145  1.000 21.03118  ? 122 LYS A CA   1 
ATOM   1884 C C    . LYS A 1 125 ? 47.43331 -15.58321 9.38879  1.000 24.53229  ? 122 LYS A C    1 
ATOM   1885 O O    . LYS A 1 125 ? 46.92248 -14.51234 8.99947  1.000 23.28870  ? 122 LYS A O    1 
ATOM   1886 C CB   . LYS A 1 125 ? 49.70338 -15.64883 8.34595  1.000 23.54282  ? 122 LYS A CB   1 
ATOM   1887 C CG   . LYS A 1 125 ? 50.49069 -15.56137 9.62849  1.000 33.63118  ? 122 LYS A CG   1 
ATOM   1888 C CD   . LYS A 1 125 ? 51.84820 -14.96365 9.40044  1.000 46.04134  ? 122 LYS A CD   1 
ATOM   1889 C CE   . LYS A 1 125 ? 52.81390 -15.95272 8.79029  1.000 59.02847  ? 122 LYS A CE   1 
ATOM   1890 N NZ   . LYS A 1 125 ? 54.18475 -15.38575 8.80481  1.000 55.30495  ? 122 LYS A NZ   1 
ATOM   1891 H H    . LYS A 1 125 ? 48.00380 -15.93286 6.60965  1.000 26.68161  ? 122 LYS A H    1 
ATOM   1892 H HA   . LYS A 1 125 ? 48.55854 -17.24134 8.87868  1.000 25.19286  ? 122 LYS A HA   1 
ATOM   1893 H HB2  . LYS A 1 125 ? 50.24992 -16.11727 7.69576  1.000 28.20683  ? 122 LYS A HB2  1 
ATOM   1894 H HB3  . LYS A 1 125 ? 49.53077 -14.74349 8.04354  1.000 28.20683  ? 122 LYS A HB3  1 
ATOM   1895 H HG2  . LYS A 1 125 ? 50.01348 -15.00179 10.26099 1.000 40.31287  ? 122 LYS A HG2  1 
ATOM   1896 H HG3  . LYS A 1 125 ? 50.60727 -16.45172 9.99536  1.000 40.31287  ? 122 LYS A HG3  1 
ATOM   1897 H HD2  . LYS A 1 125 ? 51.76658 -14.20953 8.79583  1.000 55.20506  ? 122 LYS A HD2  1 
ATOM   1898 H HD3  . LYS A 1 125 ? 52.21355 -14.66998 10.24966 1.000 55.20506  ? 122 LYS A HD3  1 
ATOM   1899 H HE2  . LYS A 1 125 ? 52.81010 -16.77504 9.30476  1.000 70.78962  ? 122 LYS A HE2  1 
ATOM   1900 H HE3  . LYS A 1 125 ? 52.56049 -16.13481 7.87186  1.000 70.78962  ? 122 LYS A HE3  1 
ATOM   1901 H HZ1  . LYS A 1 125 ? 54.75741 -15.96467 8.44562  1.000 66.32139  ? 122 LYS A HZ1  1 
ATOM   1902 H HZ2  . LYS A 1 125 ? 54.20637 -14.62950 8.33607  1.000 66.32139  ? 122 LYS A HZ2  1 
ATOM   1903 H HZ3  . LYS A 1 125 ? 54.43432 -15.21409 9.64168  1.000 66.32139  ? 122 LYS A HZ3  1 
ATOM   1904 N N    . VAL A 1 126 ? 47.20336 -16.11097 10.59247 1.000 22.34392  ? 123 VAL A N    1 
ATOM   1905 C CA   . VAL A 1 126 ? 46.25579 -15.50657 11.53195 1.000 21.47097  ? 123 VAL A CA   1 
ATOM   1906 C C    . VAL A 1 126 ? 46.83180 -15.54069 12.93021 1.000 24.07444  ? 123 VAL A C    1 
ATOM   1907 O O    . VAL A 1 126 ? 47.68164 -16.37175 13.26412 1.000 23.10337  ? 123 VAL A O    1 
ATOM   1908 C CB   . VAL A 1 126 ? 44.88502 -16.20084 11.54634 1.000 22.65248  ? 123 VAL A CB   1 
ATOM   1909 C CG1  . VAL A 1 126 ? 44.23694 -16.20305 10.18912 1.000 26.03508  ? 123 VAL A CG1  1 
ATOM   1910 C CG2  . VAL A 1 126 ? 45.01730 -17.62809 12.12730 1.000 23.34623  ? 123 VAL A CG2  1 
ATOM   1911 H H    . VAL A 1 126 ? 47.58571 -16.82191 10.88907 1.000 26.76815  ? 123 VAL A H    1 
ATOM   1912 H HA   . VAL A 1 126 ? 46.13427 -14.58257 11.26296 1.000 25.72062  ? 123 VAL A HA   1 
ATOM   1913 H HB   . VAL A 1 126 ? 44.29049 -15.69601 12.12304 1.000 27.13843  ? 123 VAL A HB   1 
ATOM   1914 H HG11 . VAL A 1 126 ? 43.39980 -16.69043 10.23970 1.000 31.19754  ? 123 VAL A HG11 1 
ATOM   1915 H HG12 . VAL A 1 126 ? 44.07044 -15.28696 9.91718  1.000 31.19754  ? 123 VAL A HG12 1 
ATOM   1916 H HG13 . VAL A 1 126 ? 44.83234 -16.63316 9.55555  1.000 31.19754  ? 123 VAL A HG13 1 
ATOM   1917 H HG21 . VAL A 1 126 ? 44.14903 -18.05995 12.10478 1.000 27.97093  ? 123 VAL A HG21 1 
ATOM   1918 H HG22 . VAL A 1 126 ? 45.65044 -18.13008 11.59061 1.000 27.97093  ? 123 VAL A HG22 1 
ATOM   1919 H HG23 . VAL A 1 126 ? 45.33346 -17.56852 13.04239 1.000 27.97093  ? 123 VAL A HG23 1 
ATOM   1920 N N    . THR A 1 127 ? 46.32604 -14.65205 13.77298 1.000 20.08692  ? 124 THR A N    1 
ATOM   1921 C CA   . THR A 1 127 ? 46.52544 -14.79880 15.20356 1.000 16.66958  ? 124 THR A CA   1 
ATOM   1922 C C    . THR A 1 127 ? 45.17860 -14.80786 15.92964 1.000 20.17037  ? 124 THR A C    1 
ATOM   1923 O O    . THR A 1 127 ? 44.13940 -14.50438 15.35390 1.000 21.00400  ? 124 THR A O    1 
ATOM   1924 C CB   . THR A 1 127 ? 47.44252 -13.68384 15.76511 1.000 20.32646  ? 124 THR A CB   1 
ATOM   1925 O OG1  . THR A 1 127 ? 47.82901 -14.03259 17.10576 1.000 22.05597  ? 124 THR A OG1  1 
ATOM   1926 C CG2  . THR A 1 127 ? 46.75061 -12.34347 15.73247 1.000 22.18348  ? 124 THR A CG2  1 
ATOM   1927 H H    . THR A 1 127 ? 45.86803 -13.96232 13.54040 1.000 24.05975  ? 124 THR A H    1 
ATOM   1928 H HA   . THR A 1 127 ? 46.95569 -15.65000 15.38033 1.000 19.95895  ? 124 THR A HA   1 
ATOM   1929 H HB   . THR A 1 127 ? 48.23885 -13.59747 15.21802 1.000 24.34720  ? 124 THR A HB   1 
ATOM   1930 H HG1  . THR A 1 127 ? 48.28610 -13.41385 17.44314 1.000 26.42261  ? 124 THR A HG1  1 
ATOM   1931 H HG21 . THR A 1 127 ? 47.34559 -11.65472 16.06789 1.000 26.57562  ? 124 THR A HG21 1 
ATOM   1932 H HG22 . THR A 1 127 ? 46.49587 -12.12368 14.82268 1.000 26.57562  ? 124 THR A HG22 1 
ATOM   1933 H HG23 . THR A 1 127 ? 45.95393 -12.36782 16.28529 1.000 26.57562  ? 124 THR A HG23 1 
ATOM   1934 N N    . THR A 1 128 ? 45.21273 -15.25617 17.18592 1.000 19.99077  ? 125 THR A N    1 
ATOM   1935 C CA   . THR A 1 128 ? 44.04108 -15.26847 18.07267 1.000 19.58318  ? 125 THR A CA   1 
ATOM   1936 C C    . THR A 1 128 ? 44.47666 -14.97307 19.50665 1.000 18.25891  ? 125 THR A C    1 
ATOM   1937 O O    . THR A 1 128 ? 45.67219 -14.88904 19.82727 1.000 20.43891  ? 125 THR A O    1 
ATOM   1938 C CB   . THR A 1 128 ? 43.34058 -16.63767 18.10123 1.000 19.59523  ? 125 THR A CB   1 
ATOM   1939 O OG1  . THR A 1 128 ? 44.20404 -17.56273 18.75655 1.000 20.48846  ? 125 THR A OG1  1 
ATOM   1940 C CG2  . THR A 1 128 ? 43.03663 -17.15856 16.66876 1.000 20.74747  ? 125 THR A CG2  1 
ATOM   1941 H H    . THR A 1 128 ? 45.92164 -15.56749 17.56026 1.000 23.94437  ? 125 THR A H    1 
ATOM   1942 H HA   . THR A 1 128 ? 43.44539 -14.58105 17.73576 1.000 23.45527  ? 125 THR A HA   1 
ATOM   1943 H HB   . THR A 1 128 ? 42.49318 -16.55939 18.56672 1.000 23.46973  ? 125 THR A HB   1 
ATOM   1944 H HG1  . THR A 1 128 ? 43.79197 -18.27721 18.91568 1.000 24.54160  ? 125 THR A HG1  1 
ATOM   1945 H HG21 . THR A 1 128 ? 42.58546 -18.01593 16.71629 1.000 24.85242  ? 125 THR A HG21 1 
ATOM   1946 H HG22 . THR A 1 128 ? 42.46677 -16.52849 16.20060 1.000 24.85242  ? 125 THR A HG22 1 
ATOM   1947 H HG23 . THR A 1 128 ? 43.86302 -17.26481 16.17208 1.000 24.85242  ? 125 THR A HG23 1 
ATOM   1948 N N    . HIS A 1 129 ? 43.51097 -14.95878 20.40745 1.000 17.84091  ? 126 HIS A N    1 
ATOM   1949 C CA   . HIS A 1 129 ? 43.86809 -15.05558 21.83092 1.000 18.82344  ? 126 HIS A CA   1 
ATOM   1950 C C    . HIS A 1 129 ? 44.61874 -16.35291 22.06366 1.000 18.48613  ? 126 HIS A C    1 
ATOM   1951 O O    . HIS A 1 129 ? 44.24255 -17.36664 21.48879 1.000 19.50786  ? 126 HIS A O    1 
ATOM   1952 C CB   . HIS A 1 129 ? 42.63173 -15.02282 22.73534 1.000 19.54298  ? 126 HIS A CB   1 
ATOM   1953 C CG   . HIS A 1 129 ? 42.96896 -14.76947 24.18175 1.000 20.65863  ? 126 HIS A CG   1 
ATOM   1954 N ND1  . HIS A 1 129 ? 43.38754 -15.77906 25.02912 1.000 20.87823  ? 126 HIS A ND1  1 
ATOM   1955 C CD2  . HIS A 1 129 ? 43.02921 -13.61438 24.90074 1.000 22.79338  ? 126 HIS A CD2  1 
ATOM   1956 C CE1  . HIS A 1 129 ? 43.69154 -15.25422 26.20735 1.000 22.86583  ? 126 HIS A CE1  1 
ATOM   1957 N NE2  . HIS A 1 129 ? 43.47029 -13.94647 26.16368 1.000 23.76360  ? 126 HIS A NE2  1 
ATOM   1958 H H    . HIS A 1 129 ? 42.67000 -14.89666 20.23863 1.000 21.36454  ? 126 HIS A H    1 
ATOM   1959 H HA   . HIS A 1 129 ? 44.42459 -14.29706 22.06724 1.000 22.54358  ? 126 HIS A HA   1 
ATOM   1960 H HB2  . HIS A 1 129 ? 42.04156 -14.31333 22.43664 1.000 23.40702  ? 126 HIS A HB2  1 
ATOM   1961 H HB3  . HIS A 1 129 ? 42.17742 -15.87800 22.67903 1.000 23.40702  ? 126 HIS A HB3  1 
ATOM   1962 H HD2  . HIS A 1 129 ? 42.81346 -12.76231 24.59690 1.000 27.30751  ? 126 HIS A HD2  1 
ATOM   1963 H HE1  . HIS A 1 129 ? 44.00808 -15.72521 26.94414 1.000 27.39445  ? 126 HIS A HE1  1 
ATOM   1964 H HE2  . HIS A 1 129 ? 43.58340 -13.39705 26.81555 1.000 28.47178  ? 126 HIS A HE2  1 
ATOM   1965 N N    . PRO A 1 130 ? 45.65433 -16.35695 22.90944 1.000 20.41611  ? 127 PRO A N    1 
ATOM   1966 C CA   . PRO A 1 130 ? 46.35840 -17.62463 23.22251 1.000 24.27113  ? 127 PRO A CA   1 
ATOM   1967 C C    . PRO A 1 130 ? 45.45155 -18.76429 23.62058 1.000 24.00448  ? 127 PRO A C    1 
ATOM   1968 O O    . PRO A 1 130 ? 45.69234 -19.92483 23.23097 1.000 24.80747  ? 127 PRO A O    1 
ATOM   1969 C CB   . PRO A 1 130 ? 47.30127 -17.23989 24.38738 1.000 27.75487  ? 127 PRO A CB   1 
ATOM   1970 C CG   . PRO A 1 130 ? 47.45832 -15.77261 24.32007 1.000 27.59139  ? 127 PRO A CG   1 
ATOM   1971 C CD   . PRO A 1 130 ? 46.26288 -15.19337 23.58325 1.000 21.94908  ? 127 PRO A CD   1 
ATOM   1972 H HA   . PRO A 1 130 ? 46.88092 -17.88616 22.44825 1.000 29.08081  ? 127 PRO A HA   1 
ATOM   1973 H HB2  . PRO A 1 130 ? 46.90132 -17.50378 25.23076 1.000 33.26130  ? 127 PRO A HB2  1 
ATOM   1974 H HB3  . PRO A 1 130 ? 48.15703 -17.68211 24.27326 1.000 33.26130  ? 127 PRO A HB3  1 
ATOM   1975 H HG2  . PRO A 1 130 ? 47.49894 -15.41718 25.22169 1.000 33.06512  ? 127 PRO A HG2  1 
ATOM   1976 H HG3  . PRO A 1 130 ? 48.27717 -15.56368 23.84390 1.000 33.06512  ? 127 PRO A HG3  1 
ATOM   1977 H HD2  . PRO A 1 130 ? 45.63710 -14.79421 24.20773 1.000 26.29435  ? 127 PRO A HD2  1 
ATOM   1978 H HD3  . PRO A 1 130 ? 46.54934 -14.53310 22.93295 1.000 26.29435  ? 127 PRO A HD3  1 
ATOM   1979 N N    . LEU A 1 131 ? 44.35191 -18.48044 24.30785 1.000 20.46393  ? 128 LEU A N    1 
ATOM   1980 C CA   . LEU A 1 131 ? 43.47090 -19.56416 24.73425 1.000 22.08926  ? 128 LEU A CA   1 
ATOM   1981 C C    . LEU A 1 131 ? 42.60667 -20.10055 23.60601 1.000 27.32765  ? 128 LEU A C    1 
ATOM   1982 O O    . LEU A 1 131 ? 41.96633 -21.13469 23.78079 1.000 27.44263  ? 128 LEU A O    1 
ATOM   1983 C CB   . LEU A 1 131 ? 42.53442 -19.06640 25.86727 1.000 24.44859  ? 128 LEU A CB   1 
ATOM   1984 C CG   . LEU A 1 131 ? 43.30610 -18.72607 27.12878 1.000 29.80291  ? 128 LEU A CG   1 
ATOM   1985 C CD1  . LEU A 1 131 ? 42.39101 -18.05792 28.16438 1.000 33.83656  ? 128 LEU A CD1  1 
ATOM   1986 C CD2  . LEU A 1 131 ? 43.94956 -19.96233 27.73499 1.000 45.19405  ? 128 LEU A CD2  1 
ATOM   1987 H H    . LEU A 1 131 ? 44.09920 -17.69026 24.53448 1.000 24.51217  ? 128 LEU A H    1 
ATOM   1988 H HA   . LEU A 1 131 ? 44.02047 -20.28749 25.07436 1.000 26.46257  ? 128 LEU A HA   1 
ATOM   1989 H HB2  . LEU A 1 131 ? 42.07007 -18.26858 25.56934 1.000 29.29375  ? 128 LEU A HB2  1 
ATOM   1990 H HB3  . LEU A 1 131 ? 41.89390 -19.76301 26.08027 1.000 29.29375  ? 128 LEU A HB3  1 
ATOM   1991 H HG   . LEU A 1 131 ? 44.01131 -18.10485 26.88867 1.000 35.71894  ? 128 LEU A HG   1 
ATOM   1992 H HD11 . LEU A 1 131 ? 42.91500 -17.82933 28.94802 1.000 40.55933  ? 128 LEU A HD11 1 
ATOM   1993 H HD12 . LEU A 1 131 ? 42.00846 -17.25530 27.77661 1.000 40.55933  ? 128 LEU A HD12 1 
ATOM   1994 H HD13 . LEU A 1 131 ? 41.68478 -18.67674 28.40769 1.000 40.55933  ? 128 LEU A HD13 1 
ATOM   1995 H HD21 . LEU A 1 131 ? 44.38120 -19.71725 28.56837 1.000 54.18831  ? 128 LEU A HD21 1 
ATOM   1996 H HD22 . LEU A 1 131 ? 43.26257 -20.62666 27.90118 1.000 54.18831  ? 128 LEU A HD22 1 
ATOM   1997 H HD23 . LEU A 1 131 ? 44.60602 -20.31373 27.11332 1.000 54.18831  ? 128 LEU A HD23 1 
ATOM   1998 N N    . ALA A 1 132 ? 42.56467 -19.42125 22.46241 1.000 21.22140  ? 129 ALA A N    1 
ATOM   1999 C CA   . ALA A 1 132 ? 41.77794 -19.86682 21.33930 1.000 19.49281  ? 129 ALA A CA   1 
ATOM   2000 C C    . ALA A 1 132 ? 42.62358 -20.53697 20.25191 1.000 23.34421  ? 129 ALA A C    1 
ATOM   2001 O O    . ALA A 1 132 ? 42.07073 -20.93339 19.23057 1.000 24.50735  ? 129 ALA A O    1 
ATOM   2002 C CB   . ALA A 1 132 ? 41.01317 -18.69403 20.70565 1.000 22.69022  ? 129 ALA A CB   1 
ATOM   2003 H H    . ALA A 1 132 ? 42.99317 -18.68932 22.32005 1.000 25.42112  ? 129 ALA A H    1 
ATOM   2004 H HA   . ALA A 1 132 ? 41.12816 -20.50612 21.67093 1.000 23.34682  ? 129 ALA A HA   1 
ATOM   2005 H HB1  . ALA A 1 132 ? 40.45436 -19.03209 19.98847 1.000 27.18372  ? 129 ALA A HB1  1 
ATOM   2006 H HB2  . ALA A 1 132 ? 40.46215 -18.27305 21.38393 1.000 27.18372  ? 129 ALA A HB2  1 
ATOM   2007 H HB3  . ALA A 1 132 ? 41.65153 -18.05396 20.35393 1.000 27.18372  ? 129 ALA A HB3  1 
ATOM   2008 N N    A LYS A 1 133 ? 43.93255 -20.65918 20.44716 0.537 20.40520  ? 130 LYS A N    1 
ATOM   2009 N N    B LYS A 1 133 ? 43.93203 -20.68582 20.46475 0.463 20.46511  ? 130 LYS A N    1 
ATOM   2010 C CA   A LYS A 1 133 ? 44.79518 -21.17515 19.38977 0.537 21.70602  ? 130 LYS A CA   1 
ATOM   2011 C CA   B LYS A 1 133 ? 44.81496 -21.16939 19.40571 0.463 21.72075  ? 130 LYS A CA   1 
ATOM   2012 C C    A LYS A 1 133 ? 44.38773 -22.58671 18.97942 0.537 23.66124  ? 130 LYS A C    1 
ATOM   2013 C C    B LYS A 1 133 ? 44.45462 -22.59180 18.98427 0.463 23.71416  ? 130 LYS A C    1 
ATOM   2014 O O    A LYS A 1 133 ? 44.23244 -22.87581 17.78329 0.537 23.84887  ? 130 LYS A O    1 
ATOM   2015 O O    B LYS A 1 133 ? 44.40725 -22.89632 17.78472 0.463 23.88069  ? 130 LYS A O    1 
ATOM   2016 C CB   A LYS A 1 133 ? 46.25323 -21.13702 19.83669 0.537 23.29603  ? 130 LYS A CB   1 
ATOM   2017 C CB   B LYS A 1 133 ? 46.27885 -21.08941 19.84733 0.463 23.38515  ? 130 LYS A CB   1 
ATOM   2018 C CG   A LYS A 1 133 ? 47.23497 -21.94795 18.94643 0.537 23.75433  ? 130 LYS A CG   1 
ATOM   2019 C CG   B LYS A 1 133 ? 47.29885 -21.71071 18.83756 0.463 23.92904  ? 130 LYS A CG   1 
ATOM   2020 C CD   A LYS A 1 133 ? 48.68267 -21.84748 19.39936 0.537 25.49598  ? 130 LYS A CD   1 
ATOM   2021 C CD   B LYS A 1 133 ? 48.75697 -21.73892 19.33838 0.463 25.51322  ? 130 LYS A CD   1 
ATOM   2022 C CE   A LYS A 1 133 ? 49.59999 -22.66623 18.47931 0.537 28.02484  ? 130 LYS A CE   1 
ATOM   2023 C CE   B LYS A 1 133 ? 49.67270 -22.46192 18.32791 0.463 28.78612  ? 130 LYS A CE   1 
ATOM   2024 N NZ   A LYS A 1 133 ? 49.95455 -24.00709 19.02169 0.537 28.90371  ? 130 LYS A NZ   1 
ATOM   2025 N NZ   B LYS A 1 133 ? 51.05673 -22.75586 18.79338 0.463 25.55047  ? 130 LYS A NZ   1 
ATOM   2026 H HA   A LYS A 1 133 ? 44.70641 -20.60370 18.61101 0.537 26.00268  ? 130 LYS A HA   1 
ATOM   2027 H HA   B LYS A 1 133 ? 44.70629 -20.59190 18.63396 0.463 26.02035  ? 130 LYS A HA   1 
ATOM   2028 H HB2  A LYS A 1 133 ? 46.55151 -20.21403 19.83223 0.537 27.91069  ? 130 LYS A HB2  1 
ATOM   2029 H HB2  B LYS A 1 133 ? 46.51509 -20.15596 19.96460 0.463 28.01762  ? 130 LYS A HB2  1 
ATOM   2030 H HB3  A LYS A 1 133 ? 46.30845 -21.49919 20.73484 0.537 27.91069  ? 130 LYS A HB3  1 
ATOM   2031 H HB3  B LYS A 1 133 ? 46.37376 -21.56380 20.68807 0.463 28.01762  ? 130 LYS A HB3  1 
ATOM   2032 H HG2  A LYS A 1 133 ? 46.98068 -22.88373 18.97010 0.537 28.46064  ? 130 LYS A HG2  1 
ATOM   2033 H HG2  B LYS A 1 133 ? 47.03509 -22.62600 18.65432 0.463 28.67029  ? 130 LYS A HG2  1 
ATOM   2034 H HG3  A LYS A 1 133 ? 47.18431 -21.61328 18.03741 0.537 28.46064  ? 130 LYS A HG3  1 
ATOM   2035 H HG3  B LYS A 1 133 ? 47.28100 -21.19015 18.01926 0.463 28.67029  ? 130 LYS A HG3  1 
ATOM   2036 H HD2  A LYS A 1 133 ? 48.96715 -20.92054 19.37185 0.537 30.55062  ? 130 LYS A HD2  1 
ATOM   2037 H HD2  B LYS A 1 133 ? 49.07858 -20.83054 19.44932 0.463 30.57132  ? 130 LYS A HD2  1 
ATOM   2038 H HD3  A LYS A 1 133 ? 48.76443 -22.19295 20.30206 0.537 30.55062  ? 130 LYS A HD3  1 
ATOM   2039 H HD3  B LYS A 1 133 ? 48.79938 -22.21152 20.18440 0.463 30.57132  ? 130 LYS A HD3  1 
ATOM   2040 H HE2  A LYS A 1 133 ? 49.15087 -22.80070 17.63013 0.537 33.58526  ? 130 LYS A HE2  1 
ATOM   2041 H HE2  B LYS A 1 133 ? 49.26208 -23.31044 18.09919 0.463 34.49880  ? 130 LYS A HE2  1 
ATOM   2042 H HE3  A LYS A 1 133 ? 50.42534 -22.17494 18.34396 0.537 33.58526  ? 130 LYS A HE3  1 
ATOM   2043 H HE3  B LYS A 1 133 ? 49.74952 -21.90649 17.53640 0.463 34.49880  ? 130 LYS A HE3  1 
ATOM   2044 H HZ1  A LYS A 1 133 ? 50.49139 -24.43295 18.45375 0.537 34.63990  ? 130 LYS A HZ1  1 
ATOM   2045 H HZ1  B LYS A 1 133 ? 51.52203 -23.14181 18.14020 0.463 30.61602  ? 130 LYS A HZ1  1 
ATOM   2046 H HZ2  A LYS A 1 133 ? 50.37201 -23.91885 19.80274 0.537 34.63990  ? 130 LYS A HZ2  1 
ATOM   2047 H HZ2  B LYS A 1 133 ? 51.46443 -22.00145 19.03159 0.463 30.61602  ? 130 LYS A HZ2  1 
ATOM   2048 H HZ3  A LYS A 1 133 ? 49.21768 -24.49170 19.14116 0.537 34.63990  ? 130 LYS A HZ3  1 
ATOM   2049 H HZ3  B LYS A 1 133 ? 51.03227 -23.30453 19.49371 0.463 30.61602  ? 130 LYS A HZ3  1 
ATOM   2050 N N    . ASP A 1 134 ? 44.22300 -23.48881 19.95202 1.000 22.64494  ? 131 ASP A N    1 
ATOM   2051 C CA   . ASP A 1 134 ? 43.98899 -24.87337 19.58098 1.000 23.90091  ? 131 ASP A CA   1 
ATOM   2052 C C    . ASP A 1 134 ? 42.71489 -25.01600 18.76152 1.000 28.76152  ? 131 ASP A C    1 
ATOM   2053 O O    . ASP A 1 134 ? 42.65900 -25.81569 17.80889 1.000 26.50049  ? 131 ASP A O    1 
ATOM   2054 C CB   . ASP A 1 134 ? 43.93933 -25.77705 20.81256 1.000 31.28880  ? 131 ASP A CB   1 
ATOM   2055 C CG   . ASP A 1 134 ? 45.27674 -25.95328 21.45956 1.000 40.38611  ? 131 ASP A CG   1 
ATOM   2056 O OD1  . ASP A 1 134 ? 46.31217 -25.68958 20.80732 1.000 34.99489  ? 131 ASP A OD1  1 
ATOM   2057 O OD2  . ASP A 1 134 ? 45.29030 -26.36670 22.62991 1.000 48.22021  ? 131 ASP A OD2  1 
ATOM   2058 H HA   . ASP A 1 134 ? 44.73760 -25.16857 19.03938 1.000 28.63654  ? 131 ASP A HA   1 
ATOM   2059 H HB2  . ASP A 1 134 ? 43.33945 -25.38604 21.46689 1.000 37.50201  ? 131 ASP A HB2  1 
ATOM   2060 H HB3  . ASP A 1 134 ? 43.61682 -26.65292 20.54847 1.000 37.50201  ? 131 ASP A HB3  1 
ATOM   2061 N N    . LYS A 1 135 ? 41.68326 -24.23657 19.10169 1.000 24.51820  ? 132 LYS A N    1 
ATOM   2062 C CA   . LYS A 1 135 ? 40.44411 -24.29095 18.35512 1.000 24.08739  ? 132 LYS A CA   1 
ATOM   2063 C C    . LYS A 1 135 ? 40.63050 -23.79417 16.92271 1.000 24.94677  ? 132 LYS A C    1 
ATOM   2064 O O    . LYS A 1 135 ? 40.12290 -24.41209 15.95996 1.000 24.16522  ? 132 LYS A O    1 
ATOM   2065 C CB   . LYS A 1 135 ? 39.38936 -23.44705 19.09386 1.000 25.51935  ? 132 LYS A CB   1 
ATOM   2066 C CG   . LYS A 1 135 ? 38.06171 -23.38093 18.40439 1.000 39.97351  ? 132 LYS A CG   1 
ATOM   2067 C CD   . LYS A 1 135 ? 36.96564 -22.91205 19.35908 1.000 63.21310  ? 132 LYS A CD   1 
ATOM   2068 C CE   . LYS A 1 135 ? 35.58925 -23.10662 18.74672 1.000 75.86890  ? 132 LYS A CE   1 
ATOM   2069 N NZ   . LYS A 1 135 ? 34.56752 -23.46627 19.77290 1.000 83.57613  ? 132 LYS A NZ   1 
ATOM   2070 H H    . LYS A 1 135 ? 41.68338 -23.67677 19.75455 1.000 29.37729  ? 132 LYS A H    1 
ATOM   2071 H HA   . LYS A 1 135 ? 40.13434 -25.20863 18.30221 1.000 28.86031  ? 132 LYS A HA   1 
ATOM   2072 H HB2  . LYS A 1 135 ? 39.24540 -23.83111 19.97288 1.000 30.57867  ? 132 LYS A HB2  1 
ATOM   2073 H HB3  . LYS A 1 135 ? 39.72218 -22.53989 19.17862 1.000 30.57867  ? 132 LYS A HB3  1 
ATOM   2074 H HG2  . LYS A 1 135 ? 38.11290 -22.75421 17.66580 1.000 47.92366  ? 132 LYS A HG2  1 
ATOM   2075 H HG3  . LYS A 1 135 ? 37.82487 -24.26231 18.07579 1.000 47.92366  ? 132 LYS A HG3  1 
ATOM   2076 H HD2  . LYS A 1 135 ? 37.01132 -23.42571 20.18064 1.000 75.81117  ? 132 LYS A HD2  1 
ATOM   2077 H HD3  . LYS A 1 135 ? 37.08571 -21.96873 19.55048 1.000 75.81117  ? 132 LYS A HD3  1 
ATOM   2078 H HE2  . LYS A 1 135 ? 35.31103 -22.28218 18.31800 1.000 90.99814  ? 132 LYS A HE2  1 
ATOM   2079 H HE3  . LYS A 1 135 ? 35.62851 -23.82311 18.09404 1.000 90.99814  ? 132 LYS A HE3  1 
ATOM   2080 H HZ1  . LYS A 1 135 ? 33.77340 -23.57604 19.38634 1.000 100.24681 ? 132 LYS A HZ1  1 
ATOM   2081 H HZ2  . LYS A 1 135 ? 34.79798 -24.22366 20.17953 1.000 100.24681 ? 132 LYS A HZ2  1 
ATOM   2082 H HZ3  . LYS A 1 135 ? 34.50584 -22.81922 20.38086 1.000 100.24681 ? 132 LYS A HZ3  1 
ATOM   2083 N N    . MET A 1 136 ? 41.35473 -22.67346 16.76264 1.000 22.21049  ? 133 MET A N    1 
ATOM   2084 C CA   . MET A 1 136 ? 41.59602 -22.10527 15.44062 1.000 21.30425  ? 133 MET A CA   1 
ATOM   2085 C C    . MET A 1 136 ? 42.41707 -23.03787 14.55234 1.000 25.50680  ? 133 MET A C    1 
ATOM   2086 O O    . MET A 1 136 ? 42.26021 -23.03436 13.32694 1.000 23.83491  ? 133 MET A O    1 
ATOM   2087 C CB   . MET A 1 136 ? 42.33223 -20.77773 15.58487 1.000 19.34867  ? 133 MET A CB   1 
ATOM   2088 C CG   . MET A 1 136 ? 42.48810 -20.00595 14.29591 1.000 19.94733  ? 133 MET A CG   1 
ATOM   2089 S SD   . MET A 1 136 ? 40.91269 -19.33399 13.81054 1.000 24.82395  ? 133 MET A SD   1 
ATOM   2090 C CE   . MET A 1 136 ? 41.29125 -18.52692 12.27137 1.000 29.51442  ? 133 MET A CE   1 
ATOM   2091 H H    . MET A 1 136 ? 41.71371 -22.22882 17.40531 1.000 26.60804  ? 133 MET A H    1 
ATOM   2092 H HA   . MET A 1 136 ? 40.73599 -21.94996 15.01975 1.000 25.52055  ? 133 MET A HA   1 
ATOM   2093 H HB2  . MET A 1 136 ? 41.83988 -20.21700 16.20461 1.000 23.17385  ? 133 MET A HB2  1 
ATOM   2094 H HB3  . MET A 1 136 ? 43.22128 -20.95332 15.93078 1.000 23.17385  ? 133 MET A HB3  1 
ATOM   2095 H HG2  . MET A 1 136 ? 43.11424 -19.27622 14.42375 1.000 23.89224  ? 133 MET A HG2  1 
ATOM   2096 H HG3  . MET A 1 136 ? 42.80601 -20.59705 13.59561 1.000 23.89224  ? 133 MET A HG3  1 
ATOM   2097 H HE1  . MET A 1 136 ? 40.48145 -18.12801 11.91642 1.000 35.37276  ? 133 MET A HE1  1 
ATOM   2098 H HE2  . MET A 1 136 ? 41.95645 -17.83914 12.43067 1.000 35.37276  ? 133 MET A HE2  1 
ATOM   2099 H HE3  . MET A 1 136 ? 41.63750 -19.18374 11.64718 1.000 35.37276  ? 133 MET A HE3  1 
ATOM   2100 N N    . MET A 1 137 ? 43.29378 -23.82279 15.15347 1.000 22.60621  ? 134 MET A N    1 
ATOM   2101 C CA   . MET A 1 137 ? 44.24516 -24.61835 14.37569 1.000 22.68981  ? 134 MET A CA   1 
ATOM   2102 C C    . MET A 1 137 ? 43.76787 -26.02705 14.09889 1.000 24.36969  ? 134 MET A C    1 
ATOM   2103 O O    . MET A 1 137 ? 44.51515 -26.79005 13.48158 1.000 22.74003  ? 134 MET A O    1 
ATOM   2104 C CB   . MET A 1 137 ? 45.59332 -24.69148 15.09719 1.000 20.87431  ? 134 MET A CB   1 
ATOM   2105 C CG   . MET A 1 137 ? 46.40399 -23.36772 15.02304 1.000 25.07424  ? 134 MET A CG   1 
ATOM   2106 S SD   . MET A 1 137 ? 46.71865 -22.77098 13.35586 1.000 25.33861  ? 134 MET A SD   1 
ATOM   2107 C CE   . MET A 1 137 ? 47.96557 -24.00997 12.81954 1.000 23.83999  ? 134 MET A CE   1 
ATOM   2108 H H    . MET A 1 137 ? 43.36204 -23.91554 16.00572 1.000 27.08290  ? 134 MET A H    1 
ATOM   2109 H HA   . MET A 1 137 ? 44.37780 -24.16368 13.52918 1.000 27.18322  ? 134 MET A HA   1 
ATOM   2110 H HB2  . MET A 1 137 ? 45.43738 -24.89329 16.03306 1.000 25.00463  ? 134 MET A HB2  1 
ATOM   2111 H HB3  . MET A 1 137 ? 46.12831 -25.39156 14.69151 1.000 25.00463  ? 134 MET A HB3  1 
ATOM   2112 H HG2  . MET A 1 137 ? 45.91007 -22.67684 15.49168 1.000 30.04453  ? 134 MET A HG2  1 
ATOM   2113 H HG3  . MET A 1 137 ? 47.26376 -23.50820 15.44960 1.000 30.04453  ? 134 MET A HG3  1 
ATOM   2114 H HE1  . MET A 1 137 ? 48.21822 -23.82660 11.90115 1.000 28.56343  ? 134 MET A HE1  1 
ATOM   2115 H HE2  . MET A 1 137 ? 48.74318 -23.94524 13.39576 1.000 28.56343  ? 134 MET A HE2  1 
ATOM   2116 H HE3  . MET A 1 137 ? 47.57809 -24.89679 12.88525 1.000 28.56343  ? 134 MET A HE3  1 
ATOM   2117 N N    . ASN A 1 138 ? 42.54792 -26.38567 14.53110 1.000 24.88693  ? 135 ASN A N    1 
ATOM   2118 C CA   . ASN A 1 138 ? 41.98503 -27.70199 14.27026 1.000 21.51225  ? 135 ASN A CA   1 
ATOM   2119 C C    . ASN A 1 138 ? 41.93540 -27.95781 12.77807 1.000 22.77887  ? 135 ASN A C    1 
ATOM   2120 O O    . ASN A 1 138 ? 41.20568 -27.27688 12.02889 1.000 23.10507  ? 135 ASN A O    1 
ATOM   2121 C CB   . ASN A 1 138 ? 40.57958 -27.78890 14.89089 1.000 24.65152  ? 135 ASN A CB   1 
ATOM   2122 C CG   . ASN A 1 138 ? 39.91668 -29.16587 14.71911 1.000 36.94980  ? 135 ASN A CG   1 
ATOM   2123 O OD1  . ASN A 1 138 ? 40.56201 -30.15809 14.44039 1.000 45.46162  ? 135 ASN A OD1  1 
ATOM   2124 N ND2  . ASN A 1 138 ? 38.61133 -29.19902 14.89388 1.000 61.60110  ? 135 ASN A ND2  1 
ATOM   2125 H H    . ASN A 1 138 ? 42.02604 -25.87245 14.98260 1.000 29.81976  ? 135 ASN A H    1 
ATOM   2126 H HA   . ASN A 1 138 ? 42.53938 -28.38710 14.67551 1.000 25.77015  ? 135 ASN A HA   1 
ATOM   2127 H HB2  . ASN A 1 138 ? 40.64535 -27.60785 15.84157 1.000 29.53727  ? 135 ASN A HB2  1 
ATOM   2128 H HB3  . ASN A 1 138 ? 40.00850 -27.12970 14.46636 1.000 29.53727  ? 135 ASN A HB3  1 
ATOM   2129 H HD21 . ASN A 1 138 ? 38.18545 -28.47835 15.09102 1.000 73.87678  ? 135 ASN A HD21 1 
ATOM   2130 H HD22 . ASN A 1 138 ? 38.18508 -29.94132 14.81084 1.000 73.87678  ? 135 ASN A HD22 1 
ATOM   2131 N N    . GLY A 1 139 ? 42.72441 -28.95138 12.33938 1.000 23.69858  ? 136 GLY A N    1 
ATOM   2132 C CA   . GLY A 1 139 ? 42.80325 -29.27273 10.92415 1.000 25.19406  ? 136 GLY A CA   1 
ATOM   2133 C C    . GLY A 1 139 ? 43.97013 -28.65765 10.16908 1.000 24.91576  ? 136 GLY A C    1 
ATOM   2134 O O    . GLY A 1 139 ? 44.23916 -29.05054 9.04449  1.000 23.85637  ? 136 GLY A O    1 
ATOM   2135 H H    . GLY A 1 139 ? 43.21545 -29.44356 12.84557 1.000 28.39375  ? 136 GLY A H    1 
ATOM   2136 H HA2  . GLY A 1 139 ? 42.87145 -30.23589 10.83163 1.000 30.18833  ? 136 GLY A HA2  1 
ATOM   2137 H HA3  . GLY A 1 139 ? 41.98715 -28.97126 10.49521 1.000 30.18833  ? 136 GLY A HA3  1 
ATOM   2138 N N    . GLY A 1 140 ? 44.66132 -27.68992 10.73105 1.000 21.27221  ? 137 GLY A N    1 
ATOM   2139 C CA   . GLY A 1 140 ? 45.81599 -27.13425 10.04122 1.000 21.65353  ? 137 GLY A CA   1 
ATOM   2140 C C    . GLY A 1 140 ? 45.52358 -26.22645 8.85780  1.000 20.62334  ? 137 GLY A C    1 
ATOM   2141 O O    . GLY A 1 140 ? 46.34877 -26.12097 7.95235  1.000 21.95712  ? 137 GLY A O    1 
ATOM   2142 H H    . GLY A 1 140 ? 44.49035 -27.33941 11.49755 1.000 25.48211  ? 137 GLY A H    1 
ATOM   2143 H HA2  . GLY A 1 140 ? 46.33351 -26.61903 10.67968 1.000 25.93969  ? 137 GLY A HA2  1 
ATOM   2144 H HA3  . GLY A 1 140 ? 46.35851 -27.86903 9.71462  1.000 25.93969  ? 137 GLY A HA3  1 
ATOM   2145 N N    . HIS A 1 141 ? 44.37280 -25.56153 8.83217  1.000 19.41318  ? 138 HIS A N    1 
ATOM   2146 C CA   . HIS A 1 141 ? 43.95983 -24.78508 7.67259  1.000 22.25763  ? 138 HIS A CA   1 
ATOM   2147 C C    . HIS A 1 141 ? 44.51305 -23.37038 7.62947  1.000 23.73768  ? 138 HIS A C    1 
ATOM   2148 O O    . HIS A 1 141 ? 44.39842 -22.71570 6.59938  1.000 23.47782  ? 138 HIS A O    1 
ATOM   2149 C CB   . HIS A 1 141 ? 42.42758 -24.70114 7.63322  1.000 22.21964  ? 138 HIS A CB   1 
ATOM   2150 C CG   . HIS A 1 141 ? 41.74331 -26.02601 7.49182  1.000 24.14310  ? 138 HIS A CG   1 
ATOM   2151 N ND1  . HIS A 1 141 ? 41.77948 -26.76819 6.32829  1.000 23.24701  ? 138 HIS A ND1  1 
ATOM   2152 C CD2  . HIS A 1 141 ? 40.96086 -26.71333 8.34974  1.000 27.60148  ? 138 HIS A CD2  1 
ATOM   2153 C CE1  . HIS A 1 141 ? 41.06717 -27.87063 6.49250  1.000 23.65412  ? 138 HIS A CE1  1 
ATOM   2154 N NE2  . HIS A 1 141 ? 40.57329 -27.86709 7.71838  1.000 26.48645  ? 138 HIS A NE2  1 
ATOM   2155 H H    . HIS A 1 141 ? 43.80883 -25.54499 9.48121  1.000 23.25127  ? 138 HIS A H    1 
ATOM   2156 H HA   . HIS A 1 141 ? 44.28563 -25.24659 6.88406  1.000 26.66461  ? 138 HIS A HA   1 
ATOM   2157 H HB2  . HIS A 1 141 ? 42.11783 -24.29674 8.45870  1.000 26.61902  ? 138 HIS A HB2  1 
ATOM   2158 H HB3  . HIS A 1 141 ? 42.16635 -24.15297 6.87680  1.000 26.61902  ? 138 HIS A HB3  1 
ATOM   2159 H HD1  . HIS A 1 141 ? 42.19879 -26.54852 5.61029  1.000 27.85186  ? 138 HIS A HD1  1 
ATOM   2160 H HD2  . HIS A 1 141 ? 40.72729 -26.45236 9.21128  1.000 33.07723  ? 138 HIS A HD2  1 
ATOM   2161 H HE1  . HIS A 1 141 ? 40.93631 -28.53455 5.85455  1.000 28.34040  ? 138 HIS A HE1  1 
ATOM   2162 N N    . TYR A 1 142 ? 45.15956 -22.91320 8.68642  1.000 21.56188  ? 139 TYR A N    1 
ATOM   2163 C CA   . TYR A 1 142 ? 45.77994 -21.60285 8.77618  1.000 21.28464  ? 139 TYR A CA   1 
ATOM   2164 C C    . TYR A 1 142 ? 47.17510 -21.81143 9.30369  1.000 22.76762  ? 139 TYR A C    1 
ATOM   2165 O O    . TYR A 1 142 ? 47.46561 -22.86435 9.87448  1.000 23.42444  ? 139 TYR A O    1 
ATOM   2166 C CB   . TYR A 1 142 ? 44.99907 -20.63898 9.76893  1.000 22.61986  ? 139 TYR A CB   1 
ATOM   2167 C CG   . TYR A 1 142 ? 43.55207 -20.46402 9.44918  1.000 21.46202  ? 139 TYR A CG   1 
ATOM   2168 C CD1  . TYR A 1 142 ? 43.13527 -19.50804 8.53210  1.000 21.84194  ? 139 TYR A CD1  1 
ATOM   2169 C CD2  . TYR A 1 142 ? 42.58116 -21.26154 10.05449 1.000 22.01089  ? 139 TYR A CD2  1 
ATOM   2170 C CE1  . TYR A 1 142 ? 41.81018 -19.36957 8.22533  1.000 23.23450  ? 139 TYR A CE1  1 
ATOM   2171 C CE2  . TYR A 1 142 ? 41.27103 -21.12980 9.74415  1.000 23.70525  ? 139 TYR A CE2  1 
ATOM   2172 C CZ   . TYR A 1 142 ? 40.87688 -20.15809 8.83810  1.000 23.62683  ? 139 TYR A CZ   1 
ATOM   2173 O OH   . TYR A 1 142 ? 39.54722 -19.97411 8.52456  1.000 26.39887  ? 139 TYR A OH   1 
ATOM   2174 H H    . TYR A 1 142 ? 45.25908 -23.37002 9.40823  1.000 25.82971  ? 139 TYR A H    1 
ATOM   2175 H HA   . TYR A 1 142 ? 45.79803 -21.18030 7.90324  1.000 25.49702  ? 139 TYR A HA   1 
ATOM   2176 H HB2  . TYR A 1 142 ? 45.05907 -21.00420 10.66554 1.000 27.09929  ? 139 TYR A HB2  1 
ATOM   2177 H HB3  . TYR A 1 142 ? 45.41389 -19.76266 9.73920  1.000 27.09929  ? 139 TYR A HB3  1 
ATOM   2178 H HD1  . TYR A 1 142 ? 43.76307 -18.95719 8.12303  1.000 26.16578  ? 139 TYR A HD1  1 
ATOM   2179 H HD2  . TYR A 1 142 ? 42.83932 -21.89604 10.68351 1.000 26.36852  ? 139 TYR A HD2  1 
ATOM   2180 H HE1  . TYR A 1 142 ? 41.54307 -18.73712 7.59799  1.000 27.83685  ? 139 TYR A HE1  1 
ATOM   2181 H HE2  . TYR A 1 142 ? 40.63885 -21.68784 10.13637 1.000 28.40175  ? 139 TYR A HE2  1 
ATOM   2182 H HH   . TYR A 1 142 ? 39.07774 -20.55207 8.91335  1.000 31.63410  ? 139 TYR A HH   1 
ATOM   2183 N N    . THR A 1 143 ? 48.01856 -20.79203 9.15790  1.000 20.51328  ? 140 THR A N    1 
ATOM   2184 C CA   . THR A 1 143 ? 49.31453 -20.73898 9.80753  1.000 23.06666  ? 140 THR A CA   1 
ATOM   2185 C C    . THR A 1 143 ? 49.26728 -19.75143 10.95604 1.000 24.47866  ? 140 THR A C    1 
ATOM   2186 O O    . THR A 1 143 ? 48.73019 -18.65329 10.80676 1.000 25.73035  ? 140 THR A O    1 
ATOM   2187 C CB   . THR A 1 143 ? 50.36689 -20.35054 8.77062  1.000 32.27784  ? 140 THR A CB   1 
ATOM   2188 O OG1  . THR A 1 143 ? 50.37475 -21.43222 7.82062  1.000 25.47856  ? 140 THR A OG1  1 
ATOM   2189 C CG2  . THR A 1 143 ? 51.73039 -20.19353 9.35334  1.000 29.06848  ? 140 THR A CG2  1 
ATOM   2190 H H    . THR A 1 143 ? 47.85245 -20.10195 8.67231  1.000 24.57138  ? 140 THR A H    1 
ATOM   2191 H HA   . THR A 1 143 ? 49.55338 -21.59674 10.19235 1.000 27.63544  ? 140 THR A HA   1 
ATOM   2192 H HB   . THR A 1 143 ? 50.15815 -19.49112 8.37221  1.000 38.68886  ? 140 THR A HB   1 
ATOM   2193 H HG1  . THR A 1 143 ? 50.93546 -21.27813 7.21443  1.000 30.52972  ? 140 THR A HG1  1 
ATOM   2194 H HG21 . THR A 1 143 ? 52.36516 -19.96668 8.65584  1.000 34.83763  ? 140 THR A HG21 1 
ATOM   2195 H HG22 . THR A 1 143 ? 51.72768 -19.48736 10.01833 1.000 34.83763  ? 140 THR A HG22 1 
ATOM   2196 H HG23 . THR A 1 143 ? 52.00845 -21.02176 9.77480  1.000 34.83763  ? 140 THR A HG23 1 
ATOM   2197 N N    . TYR A 1 144 ? 49.75430 -20.17392 12.11100 1.000 21.21639  ? 141 TYR A N    1 
ATOM   2198 C CA   . TYR A 1 144 ? 49.56854 -19.35499 13.32961 1.000 22.31713  ? 141 TYR A CA   1 
ATOM   2199 C C    . TYR A 1 144 ? 50.67532 -18.33144 13.51470 1.000 28.59798  ? 141 TYR A C    1 
ATOM   2200 O O    . TYR A 1 144 ? 51.84208 -18.60186 13.26728 1.000 26.93688  ? 141 TYR A O    1 
ATOM   2201 C CB   . TYR A 1 144 ? 49.47984 -20.25368 14.56591 1.000 22.93019  ? 141 TYR A CB   1 
ATOM   2202 C CG   . TYR A 1 144 ? 48.84225 -19.54661 15.76074 1.000 20.85877  ? 141 TYR A CG   1 
ATOM   2203 C CD1  . TYR A 1 144 ? 47.48895 -19.31158 15.76212 1.000 22.11644  ? 141 TYR A CD1  1 
ATOM   2204 C CD2  . TYR A 1 144 ? 49.60047 -19.09328 16.81141 1.000 23.52646  ? 141 TYR A CD2  1 
ATOM   2205 C CE1  . TYR A 1 144 ? 46.87270 -18.65084 16.82024 1.000 24.33047  ? 141 TYR A CE1  1 
ATOM   2206 C CE2  . TYR A 1 144 ? 48.99583 -18.42329 17.88679 1.000 23.74131  ? 141 TYR A CE2  1 
ATOM   2207 C CZ   . TYR A 1 144 ? 47.64034 -18.23015 17.86664 1.000 23.71442  ? 141 TYR A CZ   1 
ATOM   2208 O OH   . TYR A 1 144 ? 47.00131 -17.57994 18.88933 1.000 24.70779  ? 141 TYR A OH   1 
ATOM   2209 H H    . TYR A 1 144 ? 50.18609 -20.90862 12.22668 1.000 25.41512  ? 141 TYR A H    1 
ATOM   2210 H HA   . TYR A 1 144 ? 48.73921 -18.85990 13.24018 1.000 26.73600  ? 141 TYR A HA   1 
ATOM   2211 H HB2  . TYR A 1 144 ? 48.94066 -21.03156 14.35357 1.000 27.47168  ? 141 TYR A HB2  1 
ATOM   2212 H HB3  . TYR A 1 144 ? 50.37403 -20.52951 14.82136 1.000 27.47168  ? 141 TYR A HB3  1 
ATOM   2213 H HD1  . TYR A 1 144 ? 46.97502 -19.59944 15.04246 1.000 26.49518  ? 141 TYR A HD1  1 
ATOM   2214 H HD2  . TYR A 1 144 ? 50.52024 -19.23081 16.81085 1.000 28.18721  ? 141 TYR A HD2  1 
ATOM   2215 H HE1  . TYR A 1 144 ? 45.95521 -18.49890 16.81427 1.000 29.15201  ? 141 TYR A HE1  1 
ATOM   2216 H HE2  . TYR A 1 144 ? 49.50696 -18.11600 18.60038 1.000 28.44502  ? 141 TYR A HE2  1 
ATOM   2217 H HH   . TYR A 1 144 ? 47.54623 -17.40700 19.50475 1.000 29.60479  ? 141 TYR A HH   1 
ATOM   2218 N N    . SER A 1 145 ? 50.30309 -17.16429 14.03905 1.000 21.55038  ? 142 SER A N    1 
ATOM   2219 C CA   . SER A 1 145 ? 51.22111 -16.08102 14.31883 1.000 23.10932  ? 142 SER A CA   1 
ATOM   2220 C C    . SER A 1 145 ? 51.00567 -15.58890 15.74347 1.000 22.80211  ? 142 SER A C    1 
ATOM   2221 O O    . SER A 1 145 ? 49.86941 -15.56702 16.24061 1.000 25.01938  ? 142 SER A O    1 
ATOM   2222 C CB   . SER A 1 145 ? 50.96484 -14.92174 13.33552 1.000 32.53278  ? 142 SER A CB   1 
ATOM   2223 O OG   . SER A 1 145 ? 51.57614 -13.71116 13.78359 1.000 29.35113  ? 142 SER A OG   1 
ATOM   2224 H H    . SER A 1 145 ? 49.49009 -16.97607 14.24691 1.000 25.81591  ? 142 SER A H    1 
ATOM   2225 H HA   . SER A 1 145 ? 52.14009 -16.38153 14.24091 1.000 27.68663  ? 142 SER A HA   1 
ATOM   2226 H HB2  . SER A 1 145 ? 51.33427 -15.15755 12.47018 1.000 38.99479  ? 142 SER A HB2  1 
ATOM   2227 H HB3  . SER A 1 145 ? 50.00813 -14.78039 13.26045 1.000 38.99479  ? 142 SER A HB3  1 
ATOM   2228 H HG   . SER A 1 145 ? 51.45576 -13.10201 13.21786 1.000 35.17681  ? 142 SER A HG   1 
ATOM   2229 N N    . GLU A 1 146 ? 52.08282 -15.12996 16.39188 1.000 25.15873  ? 143 GLU A N    1 
ATOM   2230 C CA   . GLU A 1 146 ? 51.96736 -14.52116 17.71982 1.000 22.65010  ? 143 GLU A CA   1 
ATOM   2231 C C    . GLU A 1 146 ? 52.12729 -13.00419 17.67101 1.000 28.45125  ? 143 GLU A C    1 
ATOM   2232 O O    . GLU A 1 146 ? 52.27716 -12.36636 18.70509 1.000 26.44680  ? 143 GLU A O    1 
ATOM   2233 C CB   . GLU A 1 146 ? 53.00086 -15.09669 18.69049 1.000 30.73799  ? 143 GLU A CB   1 
ATOM   2234 C CG   . GLU A 1 146 ? 53.16817 -16.54613 18.44446 1.000 54.12267  ? 143 GLU A CG   1 
ATOM   2235 C CD   . GLU A 1 146 ? 53.48424 -17.31421 19.66750 1.000 57.70784  ? 143 GLU A CD   1 
ATOM   2236 O OE1  . GLU A 1 146 ? 52.60370 -17.39949 20.55305 1.000 68.14618  ? 143 GLU A OE1  1 
ATOM   2237 O OE2  . GLU A 1 146 ? 54.60691 -17.84036 19.73908 1.000 60.91213  ? 143 GLU A OE2  1 
ATOM   2238 H H    . GLU A 1 146 ? 52.88510 -15.16065 16.08365 1.000 30.14593  ? 143 GLU A H    1 
ATOM   2239 H HA   . GLU A 1 146 ? 51.08422 -14.73671 18.05820 1.000 27.13557  ? 143 GLU A HA   1 
ATOM   2240 H HB2  . GLU A 1 146 ? 53.85487 -14.65639 18.55750 1.000 36.84104  ? 143 GLU A HB2  1 
ATOM   2241 H HB3  . GLU A 1 146 ? 52.69947 -14.96728 19.60335 1.000 36.84104  ? 143 GLU A HB3  1 
ATOM   2242 H HG2  . GLU A 1 146 ? 52.34332 -16.89936 18.07602 1.000 64.90266  ? 143 GLU A HG2  1 
ATOM   2243 H HG3  . GLU A 1 146 ? 53.89495 -16.67599 17.81531 1.000 64.90266  ? 143 GLU A HG3  1 
ATOM   2244 N N    . ASN A 1 147 ? 52.07325 -12.40863 16.49730 1.000 27.17403  ? 144 ASN A N    1 
ATOM   2245 C CA   . ASN A 1 147 ? 52.09758 -10.95742 16.42555 1.000 23.09897  ? 144 ASN A CA   1 
ATOM   2246 C C    . ASN A 1 147 ? 50.82276 -10.38094 17.03072 1.000 23.27341  ? 144 ASN A C    1 
ATOM   2247 O O    . ASN A 1 147 ? 49.75094 -10.99808 16.97289 1.000 24.05509  ? 144 ASN A O    1 
ATOM   2248 C CB   . ASN A 1 147 ? 52.24406 -10.52073 14.99989 1.000 27.03141  ? 144 ASN A CB   1 
ATOM   2249 C CG   . ASN A 1 147 ? 53.66026 -10.71265 14.48997 1.000 31.95974  ? 144 ASN A CG   1 
ATOM   2250 O OD1  . ASN A 1 147 ? 54.61560 -10.60081 15.24122 1.000 38.62909  ? 144 ASN A OD1  1 
ATOM   2251 N ND2  . ASN A 1 147 ? 53.77925 -11.03776 13.22080 1.000 40.93293  ? 144 ASN A ND2  1 
ATOM   2252 H H    . ASN A 1 147 ? 52.02296 -12.81129 15.73906 1.000 32.56429  ? 144 ASN A H    1 
ATOM   2253 H HA   . ASN A 1 147 ? 52.85235 -10.60858 16.92508 1.000 27.67422  ? 144 ASN A HA   1 
ATOM   2254 H HB2  . ASN A 1 147 ? 51.64751 -11.04475 14.44273 1.000 32.39314  ? 144 ASN A HB2  1 
ATOM   2255 H HB3  . ASN A 1 147 ? 52.02160 -9.57916  14.93009 1.000 32.39314  ? 144 ASN A HB3  1 
ATOM   2256 H HD21 . ASN A 1 147 ? 53.07712 -11.12929 12.73271 1.000 49.07497  ? 144 ASN A HD21 1 
ATOM   2257 H HD22 . ASN A 1 147 ? 54.55917 -11.15877 12.87921 1.000 49.07497  ? 144 ASN A HD22 1 
ATOM   2258 N N    . ARG A 1 148 ? 50.92544 -9.15170  17.56203 1.000 23.09396  ? 145 ARG A N    1 
ATOM   2259 C CA   . ARG A 1 148 ? 49.76359 -8.56608  18.24053 1.000 21.69071  ? 145 ARG A CA   1 
ATOM   2260 C C    . ARG A 1 148 ? 48.66148 -8.23690  17.25995 1.000 21.37282  ? 145 ARG A C    1 
ATOM   2261 O O    . ARG A 1 148 ? 47.47541 -8.33253  17.60384 1.000 23.05784  ? 145 ARG A O    1 
ATOM   2262 C CB   . ARG A 1 148 ? 50.18751 -7.31544  19.01042 1.000 21.47539  ? 145 ARG A CB   1 
ATOM   2263 C CG   . ARG A 1 148 ? 51.11111 -7.66503  20.21644 1.000 26.50053  ? 145 ARG A CG   1 
ATOM   2264 C CD   . ARG A 1 148 ? 51.66366 -6.44269  20.92046 1.000 29.87018  ? 145 ARG A CD   1 
ATOM   2265 N NE   . ARG A 1 148 ? 50.59398 -5.61837  21.49050 1.000 32.19105  ? 145 ARG A NE   1 
ATOM   2266 C CZ   . ARG A 1 148 ? 49.99060 -5.86101  22.64898 1.000 29.58534  ? 145 ARG A CZ   1 
ATOM   2267 N NH1  . ARG A 1 148 ? 50.29169 -6.91848  23.38732 1.000 29.82304  ? 145 ARG A NH1  1 
ATOM   2268 N NH2  . ARG A 1 148 ? 49.04495 -5.02796  23.07187 1.000 30.55166  ? 145 ARG A NH2  1 
ATOM   2269 H H    . ARG A 1 148 ? 51.62891 -8.65737  17.54305 1.000 27.66820  ? 145 ARG A H    1 
ATOM   2270 H HA   . ARG A 1 148 ? 49.41322 -9.20556  18.88022 1.000 25.98430  ? 145 ARG A HA   1 
ATOM   2271 H HB2  . ARG A 1 148 ? 50.67413 -6.72364  18.41555 1.000 25.72591  ? 145 ARG A HB2  1 
ATOM   2272 H HB3  . ARG A 1 148 ? 49.39780 -6.86712  19.35140 1.000 25.72591  ? 145 ARG A HB3  1 
ATOM   2273 H HG2  . ARG A 1 148 ? 50.60218 -8.17684  20.86447 1.000 31.75609  ? 145 ARG A HG2  1 
ATOM   2274 H HG3  . ARG A 1 148 ? 51.86216 -8.18868  19.89611 1.000 31.75609  ? 145 ARG A HG3  1 
ATOM   2275 H HD2  . ARG A 1 148 ? 52.24800 -6.72471  21.64152 1.000 35.79967  ? 145 ARG A HD2  1 
ATOM   2276 H HD3  . ARG A 1 148 ? 52.15837 -5.90260  20.28449 1.000 35.79967  ? 145 ARG A HD3  1 
ATOM   2277 H HE   . ARG A 1 148 ? 50.33907 -4.92923  21.04362 1.000 38.58471  ? 145 ARG A HE   1 
ATOM   2278 H HH11 . ARG A 1 148 ? 50.89342 -7.47197  23.12053 1.000 35.74310  ? 145 ARG A HH11 1 
ATOM   2279 H HH12 . ARG A 1 148 ? 49.88547 -7.05166  24.13354 1.000 35.74310  ? 145 ARG A HH12 1 
ATOM   2280 H HH21 . ARG A 1 148 ? 48.83145 -4.34326  22.59731 1.000 36.61744  ? 145 ARG A HH21 1 
ATOM   2281 H HH22 . ARG A 1 148 ? 48.64667 -5.17370  23.82002 1.000 36.61744  ? 145 ARG A HH22 1 
ATOM   2282 N N    . VAL A 1 149 ? 49.03108 -7.80286  16.04965 1.000 22.50131  ? 146 VAL A N    1 
ATOM   2283 C CA   . VAL A 1 149 ? 48.10329 -7.63757  14.92589 1.000 19.96130  ? 146 VAL A CA   1 
ATOM   2284 C C    . VAL A 1 149 ? 48.74951 -8.35996  13.74226 1.000 22.24692  ? 146 VAL A C    1 
ATOM   2285 O O    . VAL A 1 149 ? 49.95825 -8.24335  13.55736 1.000 24.80504  ? 146 VAL A O    1 
ATOM   2286 C CB   . VAL A 1 149 ? 47.89932 -6.14744  14.58417 1.000 23.73771  ? 146 VAL A CB   1 
ATOM   2287 C CG1  . VAL A 1 149 ? 47.07127 -6.00527  13.34491 1.000 26.73336  ? 146 VAL A CG1  1 
ATOM   2288 C CG2  . VAL A 1 149 ? 47.24132 -5.42265  15.72960 1.000 26.18251  ? 146 VAL A CG2  1 
ATOM   2289 H H    . VAL A 1 149 ? 49.84030 -7.59122  15.84974 1.000 26.95702  ? 146 VAL A H    1 
ATOM   2290 H HA   . VAL A 1 149 ? 47.23750 -8.02594  15.12712 1.000 23.90900  ? 146 VAL A HA   1 
ATOM   2291 H HB   . VAL A 1 149 ? 48.76778 -5.74519  14.42646 1.000 28.44070  ? 146 VAL A HB   1 
ATOM   2292 H HG11 . VAL A 1 149 ? 46.98526 -5.06355  13.12888 1.000 32.03548  ? 146 VAL A HG11 1 
ATOM   2293 H HG12 . VAL A 1 149 ? 47.50957 -6.47297  12.61686 1.000 32.03548  ? 146 VAL A HG12 1 
ATOM   2294 H HG13 . VAL A 1 149 ? 46.19501 -6.38933  13.50481 1.000 32.03548  ? 146 VAL A HG13 1 
ATOM   2295 H HG21 . VAL A 1 149 ? 47.07817 -4.50263  15.46914 1.000 31.37446  ? 146 VAL A HG21 1 
ATOM   2296 H HG22 . VAL A 1 149 ? 46.40182 -5.86071  15.93996 1.000 31.37446  ? 146 VAL A HG22 1 
ATOM   2297 H HG23 . VAL A 1 149 ? 47.83023 -5.44888  16.49992 1.000 31.37446  ? 146 VAL A HG23 1 
ATOM   2298 N N    . GLU A 1 150 ? 47.97072 -9.14171  13.00718 1.000 22.12120  ? 147 GLU A N    1 
ATOM   2299 C CA   . GLU A 1 150 ? 48.43569 -9.87695  11.82143 1.000 20.53018  ? 147 GLU A CA   1 
ATOM   2300 C C    . GLU A 1 150 ? 47.55080 -9.51526  10.63593 1.000 26.96994  ? 147 GLU A C    1 
ATOM   2301 O O    . GLU A 1 150 ? 46.34100 -9.39519  10.75029 1.000 23.95063  ? 147 GLU A O    1 
ATOM   2302 C CB   . GLU A 1 150 ? 48.40930 -11.37833 12.04913 1.000 23.28201  ? 147 GLU A CB   1 
ATOM   2303 C CG   . GLU A 1 150 ? 49.17721 -12.23390 11.05822 1.000 27.94088  ? 147 GLU A CG   1 
ATOM   2304 C CD   . GLU A 1 150 ? 50.60506 -11.83153 10.89668 1.000 28.58779  ? 147 GLU A CD   1 
ATOM   2305 O OE1  . GLU A 1 150 ? 51.44601 -12.12911 11.75419 1.000 28.90817  ? 147 GLU A OE1  1 
ATOM   2306 O OE2  . GLU A 1 150 ? 50.87900 -11.17450 9.88898  1.000 36.13299  ? 147 GLU A OE2  1 
ATOM   2307 H H    . GLU A 1 150 ? 47.13744 -9.27173  13.17551 1.000 26.50089  ? 147 GLU A H    1 
ATOM   2308 H HA   . GLU A 1 150 ? 49.35040 -9.62583  11.61859 1.000 24.59166  ? 147 GLU A HA   1 
ATOM   2309 H HB2  . GLU A 1 150 ? 48.78408 -11.55538 12.92610 1.000 27.89386  ? 147 GLU A HB2  1 
ATOM   2310 H HB3  . GLU A 1 150 ? 47.48477 -11.67022 12.01834 1.000 27.89386  ? 147 GLU A HB3  1 
ATOM   2311 H HG2  . GLU A 1 150 ? 49.16214 -13.15458 11.36321 1.000 33.48450  ? 147 GLU A HG2  1 
ATOM   2312 H HG3  . GLU A 1 150 ? 48.75053 -12.16505 10.18983 1.000 33.48450  ? 147 GLU A HG3  1 
ATOM   2313 N N    . LYS A 1 151 ? 48.15658 -9.32309  9.47218  1.000 27.20727  ? 148 LYS A N    1 
ATOM   2314 C CA   . LYS A 1 151 ? 47.36154 -9.02070  8.28515  1.000 26.69203  ? 148 LYS A CA   1 
ATOM   2315 C C    . LYS A 1 151 ? 47.92625 -9.83861  7.13900  1.000 26.97965  ? 148 LYS A C    1 
ATOM   2316 O O    . LYS A 1 151 ? 49.13174 -9.78471  6.88859  1.000 31.76809  ? 148 LYS A O    1 
ATOM   2317 C CB   . LYS A 1 151 ? 47.38877 -7.54068  7.94947  1.000 34.26658  ? 148 LYS A CB   1 
ATOM   2318 C CG   . LYS A 1 151 ? 46.40296 -7.17057  6.83255  1.000 30.10548  ? 148 LYS A CG   1 
ATOM   2319 C CD   . LYS A 1 151 ? 46.50276 -5.68641  6.50779  1.000 41.30015  ? 148 LYS A CD   1 
ATOM   2320 C CE   . LYS A 1 151 ? 45.46743 -5.26922  5.47595  1.000 44.21753  ? 148 LYS A CE   1 
ATOM   2321 N NZ   . LYS A 1 151 ? 45.75758 -5.86583  4.14240  1.000 60.50647  ? 148 LYS A NZ   1 
ATOM   2322 H H    . LYS A 1 151 ? 49.00633 -9.36117  9.34545  1.000 32.60418  ? 148 LYS A H    1 
ATOM   2323 H HA   . LYS A 1 151 ? 46.43374 -9.26423  8.42931  1.000 31.98589  ? 148 LYS A HA   1 
ATOM   2324 H HB2  . LYS A 1 151 ? 47.15154 -7.03251  8.74092  1.000 41.07535  ? 148 LYS A HB2  1 
ATOM   2325 H HB3  . LYS A 1 151 ? 48.28112 -7.29948  7.65547  1.000 41.07535  ? 148 LYS A HB3  1 
ATOM   2326 H HG2  . LYS A 1 151 ? 46.61232 -7.67733  6.03238  1.000 36.08203  ? 148 LYS A HG2  1 
ATOM   2327 H HG3  . LYS A 1 151 ? 45.49713 -7.36427  7.12039  1.000 36.08203  ? 148 LYS A HG3  1 
ATOM   2328 H HD2  . LYS A 1 151 ? 46.35303 -5.17030  7.31533  1.000 49.51563  ? 148 LYS A HD2  1 
ATOM   2329 H HD3  . LYS A 1 151 ? 47.38373 -5.49459  6.15004  1.000 49.51563  ? 148 LYS A HD3  1 
ATOM   2330 H HE2  . LYS A 1 151 ? 44.59036 -5.57007  5.76080  1.000 53.01648  ? 148 LYS A HE2  1 
ATOM   2331 H HE3  . LYS A 1 151 ? 45.47395 -4.30339  5.38636  1.000 53.01648  ? 148 LYS A HE3  1 
ATOM   2332 H HZ1  . LYS A 1 151 ? 45.15136 -5.59544  3.54955  1.000 72.56322  ? 148 LYS A HZ1  1 
ATOM   2333 H HZ2  . LYS A 1 151 ? 46.56495 -5.61384  3.86535  1.000 72.56322  ? 148 LYS A HZ2  1 
ATOM   2334 H HZ3  . LYS A 1 151 ? 45.73434 -6.75399  4.19470  1.000 72.56322  ? 148 LYS A HZ3  1 
ATOM   2335 N N    . ASP A 1 152 ? 47.07987 -10.63010 6.50105  1.000 26.93846  ? 149 ASP A N    1 
ATOM   2336 C CA   . ASP A 1 152 ? 47.51285 -11.48777 5.39355  1.000 24.16156  ? 149 ASP A CA   1 
ATOM   2337 C C    . ASP A 1 152 ? 46.41227 -11.31294 4.35996  1.000 32.86947  ? 149 ASP A C    1 
ATOM   2338 O O    . ASP A 1 152 ? 45.29410 -11.82175 4.53373  1.000 30.21944  ? 149 ASP A O    1 
ATOM   2339 C CB   . ASP A 1 152 ? 47.70346 -12.92690 5.83678  1.000 28.69549  ? 149 ASP A CB   1 
ATOM   2340 C CG   . ASP A 1 152 ? 48.44403 -13.76954 4.80565  1.000 36.14714  ? 149 ASP A CG   1 
ATOM   2341 O OD1  . ASP A 1 152 ? 48.98131 -13.24495 3.80317  1.000 33.13615  ? 149 ASP A OD1  1 
ATOM   2342 O OD2  . ASP A 1 152 ? 48.46533 -14.97333 4.98764  1.000 27.27046  ? 149 ASP A OD2  1 
ATOM   2343 H H    . ASP A 1 152 ? 46.24268 -10.69333 6.68733  1.000 32.28160  ? 149 ASP A H    1 
ATOM   2344 H HA   . ASP A 1 152 ? 48.36707 -11.21589 5.02302  1.000 28.94932  ? 149 ASP A HA   1 
ATOM   2345 H HB2  . ASP A 1 152 ? 48.21812 -12.93869 6.65891  1.000 34.39004  ? 149 ASP A HB2  1 
ATOM   2346 H HB3  . ASP A 1 152 ? 46.83353 -13.32989 5.98416  1.000 34.39004  ? 149 ASP A HB3  1 
ATOM   2347 N N    . GLY A 1 153 ? 46.73440 -10.51800 3.33117  1.000 41.91041  ? 150 GLY A N    1 
ATOM   2348 C CA   . GLY A 1 153 ? 45.75902 -10.15988 2.31161  1.000 55.64590  ? 150 GLY A CA   1 
ATOM   2349 C C    . GLY A 1 153 ? 44.60602 -9.42271  2.93602  1.000 25.75744  ? 150 GLY A C    1 
ATOM   2350 O O    . GLY A 1 153 ? 44.78207 -8.37253  3.59012  1.000 42.26565  ? 150 GLY A O    1 
ATOM   2351 H H    . GLY A 1 153 ? 47.51305 -10.17531 3.20518  1.000 50.24794  ? 150 GLY A H    1 
ATOM   2352 H HA2  . GLY A 1 153 ? 46.17261 -9.59033  1.64418  1.000 66.73053  ? 150 GLY A HA2  1 
ATOM   2353 H HA3  . GLY A 1 153 ? 45.42368 -10.96084 1.87927  1.000 66.73053  ? 150 GLY A HA3  1 
ATOM   2354 N N    . LEU A 1 154 ? 43.42014 -9.99047  2.78177  1.000 37.53750  ? 151 LEU A N    1 
ATOM   2355 C CA   . LEU A 1 154 ? 42.20104 -9.35872  3.25517  1.000 45.44749  ? 151 LEU A CA   1 
ATOM   2356 C C    . LEU A 1 154 ? 41.75379 -9.85186  4.63075  1.000 28.92697  ? 151 LEU A C    1 
ATOM   2357 O O    . LEU A 1 154 ? 40.66743 -9.46134  5.07656  1.000 29.82769  ? 151 LEU A O    1 
ATOM   2358 C CB   . LEU A 1 154 ? 41.08208 -9.57330  2.23265  1.000 46.40315  ? 151 LEU A CB   1 
ATOM   2359 C CG   . LEU A 1 154 ? 40.46405 -10.97164 2.07542  1.000 65.34566  ? 151 LEU A CG   1 
ATOM   2360 C CD1  . LEU A 1 154 ? 39.23692 -11.17906 2.96392  1.000 57.68082  ? 151 LEU A CD1  1 
ATOM   2361 C CD2  . LEU A 1 154 ? 40.11213 -11.24508 0.59156  1.000 53.08909  ? 151 LEU A CD2  1 
ATOM   2362 H H    . LEU A 1 154 ? 43.29505 -10.75136 2.40100  1.000 45.00045  ? 151 LEU A H    1 
ATOM   2363 H HA   . LEU A 1 154 ? 42.36561 -8.40635  3.33768  1.000 54.49244  ? 151 LEU A HA   1 
ATOM   2364 H HB2  . LEU A 1 154 ? 40.35397 -8.97862  2.47161  1.000 55.63923  ? 151 LEU A HB2  1 
ATOM   2365 H HB3  . LEU A 1 154 ? 41.43553 -9.33190  1.36218  1.000 55.63923  ? 151 LEU A HB3  1 
ATOM   2366 H HG   . LEU A 1 154 ? 41.12708 -11.61722 2.36614  1.000 78.37024  ? 151 LEU A HG   1 
ATOM   2367 H HD11 . LEU A 1 154 ? 38.88778 -12.07201 2.81678  1.000 69.17243  ? 151 LEU A HD11 1 
ATOM   2368 H HD12 . LEU A 1 154 ? 39.49796 -11.07479 3.89230  1.000 69.17243  ? 151 LEU A HD12 1 
ATOM   2369 H HD13 . LEU A 1 154 ? 38.56473 -10.51890 2.73318  1.000 69.17243  ? 151 LEU A HD13 1 
ATOM   2370 H HD21 . LEU A 1 154 ? 39.71500 -12.12705 0.51853  1.000 63.66235  ? 151 LEU A HD21 1 
ATOM   2371 H HD22 . LEU A 1 154 ? 39.48274 -10.57268 0.28718  1.000 63.66235  ? 151 LEU A HD22 1 
ATOM   2372 H HD23 . LEU A 1 154 ? 40.92346 -11.20273 0.06160  1.000 63.66235  ? 151 LEU A HD23 1 
ATOM   2373 N N    . ILE A 1 155 ? 42.56249 -10.65282 5.33014  1.000 25.85746  ? 152 ILE A N    1 
ATOM   2374 C CA   . ILE A 1 155 ? 42.20974 -11.13793 6.67282  1.000 22.91215  ? 152 ILE A CA   1 
ATOM   2375 C C    . ILE A 1 155 ? 43.08836 -10.42084 7.68768  1.000 24.56707  ? 152 ILE A C    1 
ATOM   2376 O O    . ILE A 1 155 ? 44.31662 -10.57689 7.68239  1.000 23.19792  ? 152 ILE A O    1 
ATOM   2377 C CB   . ILE A 1 155 ? 42.37102 -12.65033 6.82607  1.000 30.00452  ? 152 ILE A CB   1 
ATOM   2378 C CG1  . ILE A 1 155 ? 41.56777 -13.40510 5.75835  1.000 35.80953  ? 152 ILE A CG1  1 
ATOM   2379 C CG2  . ILE A 1 155 ? 41.98810 -13.06689 8.26704  1.000 30.72626  ? 152 ILE A CG2  1 
ATOM   2380 C CD1  . ILE A 1 155 ? 40.11723 -13.37007 6.00278  1.000 38.71799  ? 152 ILE A CD1  1 
ATOM   2381 H H    . ILE A 1 155 ? 43.32556 -10.93137 5.04776  1.000 30.98440  ? 152 ILE A H    1 
ATOM   2382 H HA   . ILE A 1 155 ? 41.27985 -10.91167 6.83097  1.000 27.45002  ? 152 ILE A HA   1 
ATOM   2383 H HB   . ILE A 1 155 ? 43.29991 -12.88957 6.68174  1.000 35.96087  ? 152 ILE A HB   1 
ATOM   2384 H HG12 . ILE A 1 155 ? 41.73581 -13.00063 4.89286  1.000 42.92689  ? 152 ILE A HG12 1 
ATOM   2385 H HG13 . ILE A 1 155 ? 41.84816 -14.33366 5.75066  1.000 42.92689  ? 152 ILE A HG13 1 
ATOM   2386 H HG21 . ILE A 1 155 ? 42.06486 -14.03044 8.34817  1.000 36.82696  ? 152 ILE A HG21 1 
ATOM   2387 H HG22 . ILE A 1 155 ? 42.59038 -12.63333 8.89170  1.000 36.82696  ? 152 ILE A HG22 1 
ATOM   2388 H HG23 . ILE A 1 155 ? 41.07474 -12.79183 8.44312  1.000 36.82696  ? 152 ILE A HG23 1 
ATOM   2389 H HD11 . ILE A 1 155 ? 39.66623 -13.86026 5.29765  1.000 46.41704  ? 152 ILE A HD11 1 
ATOM   2390 H HD12 . ILE A 1 155 ? 39.93174 -13.78059 6.86183  1.000 46.41704  ? 152 ILE A HD12 1 
ATOM   2391 H HD13 . ILE A 1 155 ? 39.81977 -12.44682 6.00624  1.000 46.41704  ? 152 ILE A HD13 1 
ATOM   2392 N N    A LEU A 1 156 ? 42.45413 -9.68107  8.59925  0.612 21.36815  ? 153 LEU A N    1 
ATOM   2393 N N    B LEU A 1 156 ? 42.45940 -9.68277  8.60539  0.388 21.46926  ? 153 LEU A N    1 
ATOM   2394 C CA   A LEU A 1 156 ? 43.17313 -8.92153  9.62750  0.612 21.10235  ? 153 LEU A CA   1 
ATOM   2395 C CA   B LEU A 1 156 ? 43.17697 -8.91251  9.62759  0.388 21.30902  ? 153 LEU A CA   1 
ATOM   2396 C C    A LEU A 1 156 ? 42.75257 -9.46552  10.98041 0.612 20.33783  ? 153 LEU A C    1 
ATOM   2397 C C    B LEU A 1 156 ? 42.76358 -9.41606  11.00132 0.388 20.43688  ? 153 LEU A C    1 
ATOM   2398 O O    A LEU A 1 156 ? 41.55205 -9.51285  11.26371 0.612 22.32902  ? 153 LEU A O    1 
ATOM   2399 O O    B LEU A 1 156 ? 41.57753 -9.34841  11.33691 0.388 22.92961  ? 153 LEU A O    1 
ATOM   2400 C CB   A LEU A 1 156 ? 42.84372 -7.42970  9.46841  0.612 22.60559  ? 153 LEU A CB   1 
ATOM   2401 C CB   B LEU A 1 156 ? 42.85799 -7.41948  9.46237  0.388 22.66275  ? 153 LEU A CB   1 
ATOM   2402 C CG   A LEU A 1 156 ? 43.77324 -6.40919  10.08964 0.612 22.60360  ? 153 LEU A CG   1 
ATOM   2403 C CG   B LEU A 1 156 ? 43.30761 -6.45564  10.54876 0.388 23.00751  ? 153 LEU A CG   1 
ATOM   2404 C CD1  A LEU A 1 156 ? 43.54952 -5.10437  9.40390  0.612 25.55566  ? 153 LEU A CD1  1 
ATOM   2405 C CD1  B LEU A 1 156 ? 44.80913 -6.32526  10.57042 0.388 22.75195  ? 153 LEU A CD1  1 
ATOM   2406 C CD2  A LEU A 1 156 ? 43.44303 -6.35020  11.56811 0.612 24.01058  ? 153 LEU A CD2  1 
ATOM   2407 C CD2  B LEU A 1 156 ? 42.62230 -5.09988  10.33903 0.388 29.32385  ? 153 LEU A CD2  1 
ATOM   2408 H HA   A LEU A 1 156 ? 44.13463 -9.02987  9.55920  0.612 25.27827  ? 153 LEU A HA   1 
ATOM   2409 H HA   B LEU A 1 156 ? 44.13480 -9.04246  9.54648  0.388 25.52628  ? 153 LEU A HA   1 
ATOM   2410 H HB2  A LEU A 1 156 ? 42.81812 -7.23641  8.51821  0.612 27.08216  ? 153 LEU A HB2  1 
ATOM   2411 H HB2  B LEU A 1 156 ? 43.27456 -7.12100  8.63880  0.388 27.15075  ? 153 LEU A HB2  1 
ATOM   2412 H HB3  A LEU A 1 156 ? 41.96931 -7.28065  9.86096  0.612 27.08216  ? 153 LEU A HB3  1 
ATOM   2413 H HB3  B LEU A 1 156 ? 41.89413 -7.33199  9.39730  0.388 27.15075  ? 153 LEU A HB3  1 
ATOM   2414 H HG   A LEU A 1 156 ? 44.71273 -6.63077  9.99390  0.612 27.07977  ? 153 LEU A HG   1 
ATOM   2415 H HG   B LEU A 1 156 ? 43.04923 -6.79615  11.41950 0.388 27.56447  ? 153 LEU A HG   1 
ATOM   2416 H HD11 A LEU A 1 156 ? 44.14573 -4.44096  9.78511  0.612 30.62225  ? 153 LEU A HD11 1 
ATOM   2417 H HD11 B LEU A 1 156 ? 45.06091 -5.68792  11.25694 0.388 27.25779  ? 153 LEU A HD11 1 
ATOM   2418 H HD12 A LEU A 1 156 ? 43.73352 -5.20944  8.45732  0.612 30.62225  ? 153 LEU A HD12 1 
ATOM   2419 H HD12 B LEU A 1 156 ? 45.19862 -7.19207  10.76493 0.388 27.25779  ? 153 LEU A HD12 1 
ATOM   2420 H HD13 A LEU A 1 156 ? 42.62715 -4.83356  9.53350  0.612 30.62225  ? 153 LEU A HD13 1 
ATOM   2421 H HD13 B LEU A 1 156 ? 45.11163 -6.01383  9.70300  0.388 27.25779  ? 153 LEU A HD13 1 
ATOM   2422 H HD21 A LEU A 1 156 ? 44.00142 -5.67845  11.98984 0.612 28.76815  ? 153 LEU A HD21 1 
ATOM   2423 H HD21 B LEU A 1 156 ? 42.92662 -4.48304  11.02298 0.388 35.14407  ? 153 LEU A HD21 1 
ATOM   2424 H HD22 A LEU A 1 156 ? 42.50754 -6.11650  11.67367 0.612 28.76815  ? 153 LEU A HD22 1 
ATOM   2425 H HD22 B LEU A 1 156 ? 42.85517 -4.76086  9.46054  0.388 35.14407  ? 153 LEU A HD22 1 
ATOM   2426 H HD23 A LEU A 1 156 ? 43.61378 -7.21878  11.96473 0.612 28.76815  ? 153 LEU A HD23 1 
ATOM   2427 H HD23 B LEU A 1 156 ? 41.66174 -5.21817  10.40399 0.388 35.14407  ? 153 LEU A HD23 1 
ATOM   2428 N N    . THR A 1 157 ? 43.73517 -9.92288  11.79380 1.000 19.05417  ? 154 THR A N    1 
ATOM   2429 C CA   . THR A 1 157 ? 43.40944 -10.53994 13.08687 1.000 17.15782  ? 154 THR A CA   1 
ATOM   2430 C C    . THR A 1 157 ? 44.23088 -9.91088  14.19593 1.000 17.98255  ? 154 THR A C    1 
ATOM   2431 O O    . THR A 1 157 ? 45.26610 -9.30178  13.97375 1.000 20.45781  ? 154 THR A O    1 
ATOM   2432 C CB   . THR A 1 157 ? 43.59519 -12.08816 13.06104 1.000 18.78248  ? 154 THR A CB   1 
ATOM   2433 O OG1  . THR A 1 157 ? 44.91397 -12.41083 12.57263 1.000 20.03777  ? 154 THR A OG1  1 
ATOM   2434 C CG2  . THR A 1 157 ? 42.52782 -12.72133 12.20244 1.000 25.50709  ? 154 THR A CG2  1 
ATOM   2435 H HA   . THR A 1 157 ? 42.47773 -10.36328 13.29087 1.000 20.54483  ? 154 THR A HA   1 
ATOM   2436 H HB   . THR A 1 157 ? 43.50799 -12.45453 13.95495 1.000 22.49443  ? 154 THR A HB   1 
ATOM   2437 H HG1  . THR A 1 157 ? 44.95095 -13.22266 12.36010 1.000 24.00078  ? 154 THR A HG1  1 
ATOM   2438 H HG21 . THR A 1 157 ? 42.63210 -13.68571 12.20087 1.000 30.56396  ? 154 THR A HG21 1 
ATOM   2439 H HG22 . THR A 1 157 ? 41.64910 -12.50028 12.54869 1.000 30.56396  ? 154 THR A HG22 1 
ATOM   2440 H HG23 . THR A 1 157 ? 42.59831 -12.39559 11.29149 1.000 30.56396  ? 154 THR A HG23 1 
ATOM   2441 N N    . SER A 1 158 ? 43.75967 -10.09827 15.42764 1.000 18.20735  ? 155 SER A N    1 
ATOM   2442 C CA   . SER A 1 158 ? 44.46156 -9.55182  16.57866 1.000 20.33730  ? 155 SER A CA   1 
ATOM   2443 C C    . SER A 1 158 ? 44.09083 -10.37248 17.82417 1.000 18.57601  ? 155 SER A C    1 
ATOM   2444 O O    . SER A 1 158 ? 43.19295 -11.22050 17.79324 1.000 19.36373  ? 155 SER A O    1 
ATOM   2445 C CB   . SER A 1 158 ? 44.08735 -8.05792  16.74579 1.000 20.64322  ? 155 SER A CB   1 
ATOM   2446 O OG   . SER A 1 158 ? 44.88386 -7.47482  17.72908 1.000 20.45876  ? 155 SER A OG   1 
ATOM   2447 H H    . SER A 1 158 ? 43.04293 -10.53408 15.61726 1.000 21.80427  ? 155 SER A H    1 
ATOM   2448 H HA   . SER A 1 158 ? 45.42118 -9.63277  16.46257 1.000 24.36021  ? 155 SER A HA   1 
ATOM   2449 H HB2  . SER A 1 158 ? 44.23026 -7.59698  15.90436 1.000 24.72732  ? 155 SER A HB2  1 
ATOM   2450 H HB3  . SER A 1 158 ? 43.15583 -7.98953  17.00749 1.000 24.72732  ? 155 SER A HB3  1 
ATOM   2451 H HG   . SER A 1 158 ? 44.80641 -6.63880  17.70315 1.000 24.50596  ? 155 SER A HG   1 
ATOM   2452 N N    . ARG A 1 159 ? 44.80694 -10.11402 18.92770 1.000 19.18525  ? 156 ARG A N    1 
ATOM   2453 C CA   . ARG A 1 159 ? 44.89392 -11.13831 19.98844 1.000 19.07644  ? 156 ARG A CA   1 
ATOM   2454 C C    . ARG A 1 159 ? 43.96263 -10.96360 21.18482 1.000 22.27872  ? 156 ARG A C    1 
ATOM   2455 O O    . ARG A 1 159 ? 43.51298 -11.96967 21.73634 1.000 22.07296  ? 156 ARG A O    1 
ATOM   2456 C CB   . ARG A 1 159 ? 46.32239 -11.23431 20.50626 1.000 22.77596  ? 156 ARG A CB   1 
ATOM   2457 C CG   . ARG A 1 159 ? 47.34743 -11.60168 19.42837 1.000 19.49691  ? 156 ARG A CG   1 
ATOM   2458 C CD   . ARG A 1 159 ? 48.58907 -12.23331 19.98131 1.000 19.85088  ? 156 ARG A CD   1 
ATOM   2459 N NE   . ARG A 1 159 ? 48.36036 -13.67060 20.10322 1.000 23.97171  ? 156 ARG A NE   1 
ATOM   2460 C CZ   . ARG A 1 159 ? 49.14851 -14.54694 20.71231 1.000 26.50085  ? 156 ARG A CZ   1 
ATOM   2461 N NH1  . ARG A 1 159 ? 50.23339 -14.16106 21.33929 1.000 31.02462  ? 156 ARG A NH1  1 
ATOM   2462 N NH2  . ARG A 1 159 ? 48.84789 -15.84394 20.63593 1.000 26.11659  ? 156 ARG A NH2  1 
ATOM   2463 H H    . ARG A 1 159 ? 45.23479 -9.38410  19.08184 1.000 22.97774  ? 156 ARG A H    1 
ATOM   2464 H HA   . ARG A 1 159 ? 44.63750 -11.97747 19.57498 1.000 22.84717  ? 156 ARG A HA   1 
ATOM   2465 H HB2  . ARG A 1 159 ? 46.57785 -10.37515 20.87705 1.000 27.28660  ? 156 ARG A HB2  1 
ATOM   2466 H HB3  . ARG A 1 159 ? 46.35916 -11.91684 21.19452 1.000 27.28660  ? 156 ARG A HB3  1 
ATOM   2467 H HG2  . ARG A 1 159 ? 46.94295 -12.23163 18.81157 1.000 23.35174  ? 156 ARG A HG2  1 
ATOM   2468 H HG3  . ARG A 1 159 ? 47.60905 -10.79603 18.95573 1.000 23.35174  ? 156 ARG A HG3  1 
ATOM   2469 H HD2  . ARG A 1 159 ? 49.33588 -12.07994 19.38160 1.000 23.77650  ? 156 ARG A HD2  1 
ATOM   2470 H HD3  . ARG A 1 159 ? 48.78671 -11.86736 20.85762 1.000 23.77650  ? 156 ARG A HD3  1 
ATOM   2471 H HE   . ARG A 1 159 ? 47.64275 -13.97994 19.74414 1.000 28.72150  ? 156 ARG A HE   1 
ATOM   2472 H HH11 . ARG A 1 159 ? 50.44434 -13.32760 21.36050 1.000 37.18499  ? 156 ARG A HH11 1 
ATOM   2473 H HH12 . ARG A 1 159 ? 50.73405 -14.74140 21.72935 1.000 37.18499  ? 156 ARG A HH12 1 
ATOM   2474 H HH21 . ARG A 1 159 ? 48.15350 -16.09930 20.19752 1.000 31.29536  ? 156 ARG A HH21 1 
ATOM   2475 H HH22 . ARG A 1 159 ? 49.34843 -16.42499 21.02509 1.000 31.29536  ? 156 ARG A HH22 1 
ATOM   2476 N N    . GLY A 1 160 ? 43.64308 -9.77076  21.65176 1.000 21.09640  ? 157 GLY A N    1 
ATOM   2477 C CA   . GLY A 1 160 ? 42.84276 -9.71844  22.85653 1.000 20.38995  ? 157 GLY A CA   1 
ATOM   2478 C C    . GLY A 1 160 ? 42.40076 -8.33471  23.23694 1.000 18.50914  ? 157 GLY A C    1 
ATOM   2479 O O    . GLY A 1 160 ? 42.58540 -7.37961  22.48246 1.000 19.38084  ? 157 GLY A O    1 
ATOM   2480 H H    . GLY A 1 160 ? 43.86685 -9.01596  21.30563 1.000 25.27112  ? 157 GLY A H    1 
ATOM   2481 H HA2  . GLY A 1 160 ? 42.04893 -10.26153 22.73088 1.000 24.42339  ? 157 GLY A HA2  1 
ATOM   2482 H HA3  . GLY A 1 160 ? 43.35941 -10.08009 23.59353 1.000 24.42339  ? 157 GLY A HA3  1 
ATOM   2483 N N    . PRO A 1 161 ? 41.74704 -8.19846  24.38023 1.000 20.66533  ? 158 PRO A N    1 
ATOM   2484 C CA   . PRO A 1 161 ? 41.20901 -6.87583  24.72761 1.000 22.19390  ? 158 PRO A CA   1 
ATOM   2485 C C    . PRO A 1 161 ? 42.25659 -5.78835  24.69728 1.000 21.84605  ? 158 PRO A C    1 
ATOM   2486 O O    . PRO A 1 161 ? 42.01328 -4.66285  24.22079 1.000 21.83937  ? 158 PRO A O    1 
ATOM   2487 C CB   . PRO A 1 161 ? 40.62907 -7.10455  26.13753 1.000 29.25467  ? 158 PRO A CB   1 
ATOM   2488 C CG   . PRO A 1 161 ? 40.32150 -8.56693  26.21083 1.000 25.48790  ? 158 PRO A CG   1 
ATOM   2489 C CD   . PRO A 1 161 ? 41.38413 -9.26073  25.36455 1.000 20.86924  ? 158 PRO A CD   1 
ATOM   2490 H HA   . PRO A 1 161 ? 40.48528 -6.63357  24.12893 1.000 26.58813  ? 158 PRO A HA   1 
ATOM   2491 H HB2  . PRO A 1 161 ? 41.28572 -6.85581  26.80674 1.000 35.06106  ? 158 PRO A HB2  1 
ATOM   2492 H HB3  . PRO A 1 161 ? 39.82353 -6.57615  26.25067 1.000 35.06106  ? 158 PRO A HB3  1 
ATOM   2493 H HG2  . PRO A 1 161 ? 40.36825 -8.86502  27.13271 1.000 30.54093  ? 158 PRO A HG2  1 
ATOM   2494 H HG3  . PRO A 1 161 ? 39.43533 -8.73295  25.85301 1.000 30.54093  ? 158 PRO A HG3  1 
ATOM   2495 H HD2  . PRO A 1 161 ? 42.14979 -9.51373  25.90368 1.000 24.99854  ? 158 PRO A HD2  1 
ATOM   2496 H HD3  . PRO A 1 161 ? 41.02037 -10.04123 24.91800 1.000 24.99854  ? 158 PRO A HD3  1 
ATOM   2497 N N    . GLY A 1 162 ? 43.46167 -6.11775  25.18231 1.000 21.75693  ? 159 GLY A N    1 
ATOM   2498 C CA   . GLY A 1 162 ? 44.60861 -5.21098  25.25453 1.000 22.30600  ? 159 GLY A CA   1 
ATOM   2499 C C    . GLY A 1 162 ? 45.27989 -4.90409  23.95552 1.000 23.92131  ? 159 GLY A C    1 
ATOM   2500 O O    . GLY A 1 162 ? 46.16113 -4.03370  23.94099 1.000 24.57823  ? 159 GLY A O    1 
ATOM   2501 H H    . GLY A 1 162 ? 43.64676 -6.89919  25.49003 1.000 26.06376  ? 159 GLY A H    1 
ATOM   2502 H HA2  . GLY A 1 162 ? 44.31078 -4.36970  25.63459 1.000 26.72265  ? 159 GLY A HA2  1 
ATOM   2503 H HA3  . GLY A 1 162 ? 45.27392 -5.60435  25.84063 1.000 26.72265  ? 159 GLY A HA3  1 
ATOM   2504 N N    . THR A 1 163 ? 44.89153 -5.57609  22.84720 1.000 19.51829  ? 160 THR A N    1 
ATOM   2505 C CA   . THR A 1 163 ? 45.38711 -5.21129  21.53368 1.000 17.72048  ? 160 THR A CA   1 
ATOM   2506 C C    . THR A 1 163 ? 44.32223 -4.46181  20.73415 1.000 22.17875  ? 160 THR A C    1 
ATOM   2507 O O    . THR A 1 163 ? 44.51800 -4.20718  19.53398 1.000 20.38409  ? 160 THR A O    1 
ATOM   2508 C CB   . THR A 1 163 ? 45.84440 -6.44305  20.71133 1.000 20.87385  ? 160 THR A CB   1 
ATOM   2509 O OG1  . THR A 1 163 ? 44.71137 -7.28382  20.34377 1.000 20.85549  ? 160 THR A OG1  1 
ATOM   2510 C CG2  . THR A 1 163 ? 46.94730 -7.26612  21.39552 1.000 26.33611  ? 160 THR A CG2  1 
ATOM   2511 H H    . THR A 1 163 ? 44.34487 -6.23999  22.84837 1.000 23.37740  ? 160 THR A H    1 
ATOM   2512 H HA   . THR A 1 163 ? 46.16999 -4.65362  21.66409 1.000 21.22003  ? 160 THR A HA   1 
ATOM   2513 H HB   . THR A 1 163 ? 46.24561 -6.10280  19.89637 1.000 25.00407  ? 160 THR A HB   1 
ATOM   2514 H HG1  . THR A 1 163 ? 44.97757 -7.94920  19.90558 1.000 24.98204  ? 160 THR A HG1  1 
ATOM   2515 H HG21 . THR A 1 163 ? 47.18537 -8.02648  20.84228 1.000 31.55878  ? 160 THR A HG21 1 
ATOM   2516 H HG22 . THR A 1 163 ? 47.73513 -6.71684  21.53155 1.000 31.55878  ? 160 THR A HG22 1 
ATOM   2517 H HG23 . THR A 1 163 ? 46.63564 -7.58807  22.25582 1.000 31.55878  ? 160 THR A HG23 1 
ATOM   2518 N N    . SER A 1 164 ? 43.19064 -4.09607  21.36986 1.000 18.75285  ? 161 SER A N    1 
ATOM   2519 C CA   . SER A 1 164 ? 42.07633 -3.54794  20.61918 1.000 20.79358  ? 161 SER A CA   1 
ATOM   2520 C C    . SER A 1 164 ? 42.38222 -2.20167  19.97764 1.000 21.95293  ? 161 SER A C    1 
ATOM   2521 O O    . SER A 1 164 ? 41.84820 -1.91784  18.90158 1.000 18.86291  ? 161 SER A O    1 
ATOM   2522 C CB   . SER A 1 164 ? 40.86477 -3.39189  21.52397 1.000 19.79839  ? 161 SER A CB   1 
ATOM   2523 O OG   . SER A 1 164 ? 40.35284 -4.68653  21.89585 1.000 23.85397  ? 161 SER A OG   1 
ATOM   2524 H H    . SER A 1 164 ? 43.05803 -4.15875  22.21726 1.000 22.45887  ? 161 SER A H    1 
ATOM   2525 H HA   . SER A 1 164 ? 41.87748 -4.17755  19.90858 1.000 24.90774  ? 161 SER A HA   1 
ATOM   2526 H HB2  . SER A 1 164 ? 41.12515 -2.91032  22.32472 1.000 23.71352  ? 161 SER A HB2  1 
ATOM   2527 H HB3  . SER A 1 164 ? 40.17509 -2.90055  21.05087 1.000 23.71352  ? 161 SER A HB3  1 
ATOM   2528 H HG   . SER A 1 164 ? 39.69663 -4.59835  22.41277 1.000 28.58022  ? 161 SER A HG   1 
ATOM   2529 N N    . PHE A 1 165 ? 43.18307 -1.35324  20.60942 1.000 20.15026  ? 162 PHE A N    1 
ATOM   2530 C CA   . PHE A 1 165 ? 43.51688 -0.07688  19.95290 1.000 19.68344  ? 162 PHE A CA   1 
ATOM   2531 C C    . PHE A 1 165 ? 44.37071 -0.28993  18.70269 1.000 18.75865  ? 162 PHE A C    1 
ATOM   2532 O O    . PHE A 1 165 ? 44.14290 0.34041   17.66427 1.000 20.53082  ? 162 PHE A O    1 
ATOM   2533 C CB   . PHE A 1 165 ? 44.26362 0.84251   20.91949 1.000 20.14421  ? 162 PHE A CB   1 
ATOM   2534 C CG   . PHE A 1 165 ? 43.37907 1.50109   21.94560 1.000 22.31347  ? 162 PHE A CG   1 
ATOM   2535 C CD1  . PHE A 1 165 ? 42.60961 2.58355   21.57271 1.000 23.86155  ? 162 PHE A CD1  1 
ATOM   2536 C CD2  . PHE A 1 165 ? 43.32697 1.06066   23.24269 1.000 26.07114  ? 162 PHE A CD2  1 
ATOM   2537 C CE1  . PHE A 1 165 ? 41.77437 3.21125   22.52484 1.000 25.23044  ? 162 PHE A CE1  1 
ATOM   2538 C CE2  . PHE A 1 165 ? 42.50707 1.69386   24.19242 1.000 29.45518  ? 162 PHE A CE2  1 
ATOM   2539 C CZ   . PHE A 1 165 ? 41.73674 2.76411   23.79823 1.000 26.12281  ? 162 PHE A CZ   1 
ATOM   2540 H H    . PHE A 1 165 ? 43.53531 -1.47826  21.38395 1.000 24.13577  ? 162 PHE A H    1 
ATOM   2541 H HA   . PHE A 1 165 ? 42.68295 0.34582   19.69446 1.000 23.57558  ? 162 PHE A HA   1 
ATOM   2542 H HB2  . PHE A 1 165 ? 44.92832 0.31991   21.39485 1.000 24.12850  ? 162 PHE A HB2  1 
ATOM   2543 H HB3  . PHE A 1 165 ? 44.69654 1.54458   20.40902 1.000 24.12850  ? 162 PHE A HB3  1 
ATOM   2544 H HD1  . PHE A 1 165 ? 42.64022 2.89909   20.69841 1.000 28.58932  ? 162 PHE A HD1  1 
ATOM   2545 H HD2  . PHE A 1 165 ? 43.84293 0.33044   23.49855 1.000 31.24082  ? 162 PHE A HD2  1 
ATOM   2546 H HE1  . PHE A 1 165 ? 41.24832 3.93562   22.27295 1.000 30.23197  ? 162 PHE A HE1  1 
ATOM   2547 H HE2  . PHE A 1 165 ? 42.48541 1.39463   25.07270 1.000 35.30166  ? 162 PHE A HE2  1 
ATOM   2548 H HZ   . PHE A 1 165 ? 41.18358 3.18440   24.41651 1.000 31.30282  ? 162 PHE A HZ   1 
ATOM   2549 N N    . GLU A 1 166 ? 45.38483 -1.14338  18.81123 1.000 20.05764  ? 163 GLU A N    1 
ATOM   2550 C CA   . GLU A 1 166 ? 46.24114 -1.47143  17.67358 1.000 23.57189  ? 163 GLU A CA   1 
ATOM   2551 C C    . GLU A 1 166 ? 45.44108 -2.09364  16.52217 1.000 20.95447  ? 163 GLU A C    1 
ATOM   2552 O O    . GLU A 1 166 ? 45.65805 -1.75287  15.34957 1.000 22.10494  ? 163 GLU A O    1 
ATOM   2553 C CB   . GLU A 1 166 ? 47.35026 -2.43020  18.13450 1.000 22.63103  ? 163 GLU A CB   1 
ATOM   2554 C CG   . GLU A 1 166 ? 48.33942 -1.80917  19.08198 1.000 26.77791  ? 163 GLU A CG   1 
ATOM   2555 C CD   . GLU A 1 166 ? 48.98090 -2.85157  19.99167 1.000 43.74650  ? 163 GLU A CD   1 
ATOM   2556 O OE1  . GLU A 1 166 ? 49.98075 -3.47660  19.57745 1.000 35.19853  ? 163 GLU A OE1  1 
ATOM   2557 O OE2  . GLU A 1 166 ? 48.45699 -3.05342  21.10859 1.000 41.93154  ? 163 GLU A OE2  1 
ATOM   2558 H H    . GLU A 1 166 ? 45.60178 -1.55035  19.53711 1.000 24.02462  ? 163 GLU A H    1 
ATOM   2559 H HA   . GLU A 1 166 ? 46.64829 -0.65666  17.34000 1.000 28.24171  ? 163 GLU A HA   1 
ATOM   2560 H HB2  . GLU A 1 166 ? 46.94122 -3.18434  18.58711 1.000 27.11269  ? 163 GLU A HB2  1 
ATOM   2561 H HB3  . GLU A 1 166 ? 47.84003 -2.73673  17.35536 1.000 27.11269  ? 163 GLU A HB3  1 
ATOM   2562 H HG2  . GLU A 1 166 ? 49.04216 -1.37616  18.57250 1.000 32.08894  ? 163 GLU A HG2  1 
ATOM   2563 H HG3  . GLU A 1 166 ? 47.88410 -1.15832  19.63874 1.000 32.08894  ? 163 GLU A HG3  1 
ATOM   2564 N N    . PHE A 1 167 ? 44.49561 -2.97723  16.84236 1.000 18.28006  ? 164 PHE A N    1 
ATOM   2565 C CA   . PHE A 1 167 ? 43.61103 -3.58896  15.85409 1.000 16.88723  ? 164 PHE A CA   1 
ATOM   2566 C C    . PHE A 1 167 ? 42.75145 -2.53019  15.17375 1.000 21.17577  ? 164 PHE A C    1 
ATOM   2567 O O    . PHE A 1 167 ? 42.65944 -2.49152  13.94320 1.000 19.93594  ? 164 PHE A O    1 
ATOM   2568 C CB   . PHE A 1 167 ? 42.75421 -4.60735  16.61734 1.000 19.68780  ? 164 PHE A CB   1 
ATOM   2569 C CG   . PHE A 1 167 ? 41.58080 -5.21213  15.86807 1.000 20.79809  ? 164 PHE A CG   1 
ATOM   2570 C CD1  . PHE A 1 167 ? 41.77252 -6.16964  14.91166 1.000 19.97204  ? 164 PHE A CD1  1 
ATOM   2571 C CD2  . PHE A 1 167 ? 40.28925 -4.92318  16.27255 1.000 21.45166  ? 164 PHE A CD2  1 
ATOM   2572 C CE1  . PHE A 1 167 ? 40.68297 -6.78219  14.30971 1.000 20.67700  ? 164 PHE A CE1  1 
ATOM   2573 C CE2  . PHE A 1 167 ? 39.21204 -5.52962  15.70241 1.000 22.23923  ? 164 PHE A CE2  1 
ATOM   2574 C CZ   . PHE A 1 167 ? 39.41825 -6.48369  14.71433 1.000 20.32534  ? 164 PHE A CZ   1 
ATOM   2575 H H    . PHE A 1 167 ? 44.34183 -3.24615  17.64463 1.000 21.89152  ? 164 PHE A H    1 
ATOM   2576 H HA   . PHE A 1 167 ? 44.10725 -4.03594  15.15061 1.000 20.22013  ? 164 PHE A HA   1 
ATOM   2577 H HB2  . PHE A 1 167 ? 43.32831 -5.34209  16.88466 1.000 23.58081  ? 164 PHE A HB2  1 
ATOM   2578 H HB3  . PHE A 1 167 ? 42.39219 -4.16675  17.40201 1.000 23.58081  ? 164 PHE A HB3  1 
ATOM   2579 H HD1  . PHE A 1 167 ? 42.63572 -6.41116  14.66377 1.000 23.92190  ? 164 PHE A HD1  1 
ATOM   2580 H HD2  . PHE A 1 167 ? 40.15406 -4.30017  16.94966 1.000 25.69744  ? 164 PHE A HD2  1 
ATOM   2581 H HE1  . PHE A 1 167 ? 40.81733 -7.39924  13.62699 1.000 24.76785  ? 164 PHE A HE1  1 
ATOM   2582 H HE2  . PHE A 1 167 ? 38.34965 -5.30805  15.97090 1.000 26.64253  ? 164 PHE A HE2  1 
ATOM   2583 H HZ   . PHE A 1 167 ? 38.69203 -6.91862  14.32917 1.000 24.34586  ? 164 PHE A HZ   1 
ATOM   2584 N N    . ALA A 1 168 ? 42.15296 -1.61326  15.95294 1.000 21.08269  ? 165 ALA A N    1 
ATOM   2585 C CA   . ALA A 1 168 ? 41.30417 -0.59947  15.31404 1.000 19.14297  ? 165 ALA A CA   1 
ATOM   2586 C C    . ALA A 1 168 ? 42.09567 0.34114   14.43301 1.000 19.45054  ? 165 ALA A C    1 
ATOM   2587 O O    . ALA A 1 168 ? 41.62812 0.72750   13.35432 1.000 23.25708  ? 165 ALA A O    1 
ATOM   2588 C CB   . ALA A 1 168 ? 40.54978 0.19288   16.37565 1.000 21.15215  ? 165 ALA A CB   1 
ATOM   2589 H H    . ALA A 1 168 ? 42.21970 -1.56059  16.80873 1.000 25.25468  ? 165 ALA A H    1 
ATOM   2590 H HA   . ALA A 1 168 ? 40.66283 -1.06054  14.75102 1.000 22.92702  ? 165 ALA A HA   1 
ATOM   2591 H HB1  . ALA A 1 168 ? 39.97967 0.84421   15.93788 1.000 25.33803  ? 165 ALA A HB1  1 
ATOM   2592 H HB2  . ALA A 1 168 ? 40.01055 -0.41802  16.90190 1.000 25.33803  ? 165 ALA A HB2  1 
ATOM   2593 H HB3  . ALA A 1 168 ? 41.19028 0.64486   16.94694 1.000 25.33803  ? 165 ALA A HB3  1 
ATOM   2594 N N    . LEU A 1 169 ? 43.29095 0.73026   14.87163 1.000 19.22496  ? 166 LEU A N    1 
ATOM   2595 C CA   . LEU A 1 169 ? 44.11135 1.61967   14.05421 1.000 19.43858  ? 166 LEU A CA   1 
ATOM   2596 C C    . LEU A 1 169 ? 44.60759 0.94343   12.79068 1.000 21.94220  ? 166 LEU A C    1 
ATOM   2597 O O    . LEU A 1 169 ? 44.79376 1.60858   11.75900 1.000 22.69435  ? 166 LEU A O    1 
ATOM   2598 C CB   . LEU A 1 169 ? 45.26960 2.15504   14.87550 1.000 21.74188  ? 166 LEU A CB   1 
ATOM   2599 C CG   . LEU A 1 169 ? 44.80163 3.21190   15.89902 1.000 26.22497  ? 166 LEU A CG   1 
ATOM   2600 C CD1  . LEU A 1 169 ? 45.87655 3.47155   16.92741 1.000 28.36097  ? 166 LEU A CD1  1 
ATOM   2601 C CD2  . LEU A 1 169 ? 44.43421 4.52427   15.26041 1.000 28.37952  ? 166 LEU A CD2  1 
ATOM   2602 H H    . LEU A 1 169 ? 43.64268 0.49927   15.62165 1.000 23.02541  ? 166 LEU A H    1 
ATOM   2603 H HA   . LEU A 1 169 ? 43.56927 2.37495   13.77744 1.000 23.28174  ? 166 LEU A HA   1 
ATOM   2604 H HB2  . LEU A 1 169 ? 45.68319 1.42309   15.35933 1.000 26.04571  ? 166 LEU A HB2  1 
ATOM   2605 H HB3  . LEU A 1 169 ? 45.91675 2.56878   14.28311 1.000 26.04571  ? 166 LEU A HB3  1 
ATOM   2606 H HG   . LEU A 1 169 ? 44.00756 2.85031   16.32282 1.000 31.42542  ? 166 LEU A HG   1 
ATOM   2607 H HD11 . LEU A 1 169 ? 45.57370 4.16688   17.53214 1.000 33.98861  ? 166 LEU A HD11 1 
ATOM   2608 H HD12 . LEU A 1 169 ? 46.04514 2.65394   17.42136 1.000 33.98861  ? 166 LEU A HD12 1 
ATOM   2609 H HD13 . LEU A 1 169 ? 46.68520 3.75674   16.47390 1.000 33.98861  ? 166 LEU A HD13 1 
ATOM   2610 H HD21 . LEU A 1 169 ? 44.14785 5.14231   15.95100 1.000 34.01088  ? 166 LEU A HD21 1 
ATOM   2611 H HD22 . LEU A 1 169 ? 45.21037 4.87954   14.79969 1.000 34.01088  ? 166 LEU A HD22 1 
ATOM   2612 H HD23 . LEU A 1 169 ? 43.71312 4.37707   14.62853 1.000 34.01088  ? 166 LEU A HD23 1 
ATOM   2613 N N    . ALA A 1 170 ? 44.82982 -0.36635  12.83817 1.000 21.49531  ? 167 ALA A N    1 
ATOM   2614 C CA   . ALA A 1 170 ? 45.15705 -1.09516  11.61427 1.000 23.06965  ? 167 ALA A CA   1 
ATOM   2615 C C    . ALA A 1 170 ? 44.01721 -1.07975  10.60855 1.000 24.72062  ? 167 ALA A C    1 
ATOM   2616 O O    . ALA A 1 170 ? 44.26567 -1.02064  9.39507  1.000 25.12211  ? 167 ALA A O    1 
ATOM   2617 C CB   . ALA A 1 170 ? 45.52559 -2.55164  11.93146 1.000 21.40067  ? 167 ALA A CB   1 
ATOM   2618 H H    . ALA A 1 170 ? 44.79861 -0.84839  13.54969 1.000 25.74983  ? 167 ALA A H    1 
ATOM   2619 H HA   . ALA A 1 170 ? 45.92392 -0.65321  11.21743 1.000 27.63903  ? 167 ALA A HA   1 
ATOM   2620 H HB1  . ALA A 1 170 ? 45.75208 -3.00713  11.10554 1.000 25.63625  ? 167 ALA A HB1  1 
ATOM   2621 H HB2  . ALA A 1 170 ? 46.28598 -2.56103  12.53364 1.000 25.63625  ? 167 ALA A HB2  1 
ATOM   2622 H HB3  . ALA A 1 170 ? 44.76611 -2.98541  12.35090 1.000 25.63625  ? 167 ALA A HB3  1 
ATOM   2623 N N    . ILE A 1 171 ? 42.76913 -1.19326  11.08859 1.000 22.07677  ? 168 ILE A N    1 
ATOM   2624 C CA   . ILE A 1 171 ? 41.61978 -1.07254  10.19866 1.000 22.06400  ? 168 ILE A CA   1 
ATOM   2625 C C    . ILE A 1 171 ? 41.59436 0.31482   9.56339  1.000 24.56604  ? 168 ILE A C    1 
ATOM   2626 O O    . ILE A 1 171 ? 41.41029 0.45663   8.35122  1.000 23.66078  ? 168 ILE A O    1 
ATOM   2627 C CB   . ILE A 1 171 ? 40.30147 -1.36584  10.93212 1.000 23.21982  ? 168 ILE A CB   1 
ATOM   2628 C CG1  . ILE A 1 171 ? 40.23662 -2.83354  11.36770 1.000 21.48575  ? 168 ILE A CG1  1 
ATOM   2629 C CG2  . ILE A 1 171 ? 39.10046 -1.01601  10.01208 1.000 26.18876  ? 168 ILE A CG2  1 
ATOM   2630 C CD1  . ILE A 1 171 ? 39.20060 -3.10579  12.40672 1.000 27.58032  ? 168 ILE A CD1  1 
ATOM   2631 H H    . ILE A 1 171 ? 42.57026 -1.33778  11.91270 1.000 26.44757  ? 168 ILE A H    1 
ATOM   2632 H HA   . ILE A 1 171 ? 41.71721 -1.73802  9.49970  1.000 26.43225  ? 168 ILE A HA   1 
ATOM   2633 H HB   . ILE A 1 171 ? 40.26182 -0.81528  11.72974 1.000 27.81924  ? 168 ILE A HB   1 
ATOM   2634 H HG12 . ILE A 1 171 ? 40.03037 -3.38007  10.59332 1.000 25.73835  ? 168 ILE A HG12 1 
ATOM   2635 H HG13 . ILE A 1 171 ? 41.09779 -3.08871  11.73400 1.000 25.73835  ? 168 ILE A HG13 1 
ATOM   2636 H HG21 . ILE A 1 171 ? 38.27564 -1.24143  10.47008 1.000 31.38196  ? 168 ILE A HG21 1 
ATOM   2637 H HG22 . ILE A 1 171 ? 39.12018 -0.06658  9.81434  1.000 31.38196  ? 168 ILE A HG22 1 
ATOM   2638 H HG23 . ILE A 1 171 ? 39.17280 -1.52657  9.19050  1.000 31.38196  ? 168 ILE A HG23 1 
ATOM   2639 H HD11 . ILE A 1 171 ? 39.14738 -4.06268  12.55650 1.000 33.05184  ? 168 ILE A HD11 1 
ATOM   2640 H HD12 . ILE A 1 171 ? 39.45165 -2.65581  13.22854 1.000 33.05184  ? 168 ILE A HD12 1 
ATOM   2641 H HD13 . ILE A 1 171 ? 38.34504 -2.77173  12.09474 1.000 33.05184  ? 168 ILE A HD13 1 
ATOM   2642 N N    . VAL A 1 172 ? 41.81173 1.35814   10.36787 1.000 23.20592  ? 169 VAL A N    1 
ATOM   2643 C CA   . VAL A 1 172 ? 41.81803 2.72384   9.83306  1.000 20.33398  ? 169 VAL A CA   1 
ATOM   2644 C C    . VAL A 1 172 ? 42.91287 2.87853   8.78636  1.000 25.30824  ? 169 VAL A C    1 
ATOM   2645 O O    . VAL A 1 172 ? 42.70750 3.46093   7.72040  1.000 28.29972  ? 169 VAL A O    1 
ATOM   2646 C CB   . VAL A 1 172 ? 41.99422 3.74747   10.96741 1.000 21.08143  ? 169 VAL A CB   1 
ATOM   2647 C CG1  . VAL A 1 172 ? 42.16791 5.12180   10.42559 1.000 26.74756  ? 169 VAL A CG1  1 
ATOM   2648 C CG2  . VAL A 1 172 ? 40.75032 3.71792   11.90952 1.000 24.67201  ? 169 VAL A CG2  1 
ATOM   2649 H H    . VAL A 1 172 ? 41.95610 1.30485   11.21399 1.000 27.80256  ? 169 VAL A H    1 
ATOM   2650 H HA   . VAL A 1 172 ? 40.96202 2.88559   9.40648  1.000 24.35623  ? 169 VAL A HA   1 
ATOM   2651 H HB   . VAL A 1 172 ? 42.78962 3.51258   11.47046 1.000 25.25317  ? 169 VAL A HB   1 
ATOM   2652 H HG11 . VAL A 1 172 ? 42.27820 5.74084   11.16419 1.000 32.05252  ? 169 VAL A HG11 1 
ATOM   2653 H HG12 . VAL A 1 172 ? 42.95437 5.14047   9.85811  1.000 32.05252  ? 169 VAL A HG12 1 
ATOM   2654 H HG13 . VAL A 1 172 ? 41.38181 5.35944   9.90938  1.000 32.05252  ? 169 VAL A HG13 1 
ATOM   2655 H HG21 . VAL A 1 172 ? 40.87075 4.37556   12.61230 1.000 29.56186  ? 169 VAL A HG21 1 
ATOM   2656 H HG22 . VAL A 1 172 ? 39.95723 3.92817   11.39213 1.000 29.56186  ? 169 VAL A HG22 1 
ATOM   2657 H HG23 . VAL A 1 172 ? 40.66789 2.83208   12.29605 1.000 29.56186  ? 169 VAL A HG23 1 
ATOM   2658 N N    . GLU A 1 173 ? 44.10022 2.37790   9.07648  1.000 22.28729  ? 170 GLU A N    1 
ATOM   2659 C CA   . GLU A 1 173 ? 45.18369 2.48498   8.10825  1.000 23.99173  ? 170 GLU A CA   1 
ATOM   2660 C C    . GLU A 1 173 ? 44.84579 1.75123   6.81607  1.000 26.20953  ? 170 GLU A C    1 
ATOM   2661 O O    . GLU A 1 173 ? 45.08577 2.26905   5.72431  1.000 29.49932  ? 170 GLU A O    1 
ATOM   2662 C CB   . GLU A 1 173 ? 46.49270 1.95624   8.71697  1.000 26.99825  ? 170 GLU A CB   1 
ATOM   2663 C CG   . GLU A 1 173 ? 47.68512 2.09204   7.80497  1.000 41.20787  ? 170 GLU A CG   1 
ATOM   2664 C CD   . GLU A 1 173 ? 48.98936 1.68297   8.47078  1.000 59.41256  ? 170 GLU A CD   1 
ATOM   2665 O OE1  . GLU A 1 173 ? 49.09212 1.75996   9.72046  1.000 56.67737  ? 170 GLU A OE1  1 
ATOM   2666 O OE2  . GLU A 1 173 ? 49.90937 1.28271   7.72950  1.000 61.14119  ? 170 GLU A OE2  1 
ATOM   2667 H H    . GLU A 1 173 ? 44.30497 1.97885   9.81027  1.000 26.70020  ? 170 GLU A H    1 
ATOM   2668 H HA   . GLU A 1 173 ? 45.31743 3.42056   7.88984  1.000 28.74553  ? 170 GLU A HA   1 
ATOM   2669 H HB2  . GLU A 1 173 ? 46.68229 2.45307   9.52822  1.000 32.35334  ? 170 GLU A HB2  1 
ATOM   2670 H HB3  . GLU A 1 173 ? 46.38291 1.01466   8.92260  1.000 32.35334  ? 170 GLU A HB3  1 
ATOM   2671 H HG2  . GLU A 1 173 ? 47.55476 1.52520   7.02870  1.000 49.40489  ? 170 GLU A HG2  1 
ATOM   2672 H HG3  . GLU A 1 173 ? 47.76756 3.01837   7.52926  1.000 49.40489  ? 170 GLU A HG3  1 
ATOM   2673 N N    . ALA A 1 174 ? 44.26243 0.56259   6.91649  1.000 25.36205  ? 171 ALA A N    1 
ATOM   2674 C CA   . ALA A 1 174 ? 43.88574 -0.19087  5.73093  1.000 29.28315  ? 171 ALA A CA   1 
ATOM   2675 C C    . ALA A 1 174 ? 42.85124 0.54931   4.89037  1.000 33.79922  ? 171 ALA A C    1 
ATOM   2676 O O    . ALA A 1 174 ? 42.87135 0.45728   3.66326  1.000 33.63528  ? 171 ALA A O    1 
ATOM   2677 C CB   . ALA A 1 174 ? 43.32279 -1.55583  6.10348  1.000 28.88291  ? 171 ALA A CB   1 
ATOM   2678 H H    . ALA A 1 174 ? 44.07404 0.17077   7.65850  1.000 30.38992  ? 171 ALA A H    1 
ATOM   2679 H HA   . ALA A 1 174 ? 44.69315 -0.31572  5.20806  1.000 35.09523  ? 171 ALA A HA   1 
ATOM   2680 H HB1  . ALA A 1 174 ? 43.08571 -2.03178  5.29221  1.000 34.61494  ? 171 ALA A HB1  1 
ATOM   2681 H HB2  . ALA A 1 174 ? 43.99682 -2.05243  6.59335  1.000 34.61494  ? 171 ALA A HB2  1 
ATOM   2682 H HB3  . ALA A 1 174 ? 42.53560 -1.43249  6.65667  1.000 34.61494  ? 171 ALA A HB3  1 
ATOM   2683 N N    A LEU A 1 175 ? 41.92532 1.26909   5.52941  0.429 27.67926  ? 172 LEU A N    1 
ATOM   2684 N N    B LEU A 1 175 ? 41.92221 1.26809   5.52095  0.571 27.60443  ? 172 LEU A N    1 
ATOM   2685 C CA   A LEU A 1 175 ? 40.84083 1.86524   4.76073  0.429 28.36257  ? 172 LEU A CA   1 
ATOM   2686 C CA   B LEU A 1 175 ? 40.86113 1.86896   4.72532  0.571 28.37820  ? 172 LEU A CA   1 
ATOM   2687 C C    A LEU A 1 175 ? 41.13776 3.30235   4.35266  0.429 38.90650  ? 172 LEU A C    1 
ATOM   2688 C C    B LEU A 1 175 ? 41.16053 3.30656   4.33665  0.571 38.82136  ? 172 LEU A C    1 
ATOM   2689 O O    A LEU A 1 175 ? 40.80962 3.70315   3.22927  0.429 35.37915  ? 172 LEU A O    1 
ATOM   2690 O O    B LEU A 1 175 ? 40.85749 3.71154   3.20949  0.571 35.31805  ? 172 LEU A O    1 
ATOM   2691 C CB   A LEU A 1 175 ? 39.54317 1.83849   5.55992  0.429 27.20733  ? 172 LEU A CB   1 
ATOM   2692 C CB   B LEU A 1 175 ? 39.53900 1.83732   5.47730  0.571 26.91499  ? 172 LEU A CB   1 
ATOM   2693 C CG   A LEU A 1 175 ? 38.58896 0.65640   5.39329  0.429 31.57713  ? 172 LEU A CG   1 
ATOM   2694 C CG   B LEU A 1 175 ? 38.92981 0.47043   5.77631  0.571 27.41185  ? 172 LEU A CG   1 
ATOM   2695 C CD1  A LEU A 1 175 ? 39.29090 -0.65706  5.58415  0.429 31.99099  ? 172 LEU A CD1  1 
ATOM   2696 C CD1  B LEU A 1 175 ? 37.65872 0.66637   6.58614  0.571 31.21805  ? 172 LEU A CD1  1 
ATOM   2697 C CD2  A LEU A 1 175 ? 37.45020 0.79218   6.40499  0.429 31.00299  ? 172 LEU A CD2  1 
ATOM   2698 C CD2  B LEU A 1 175 ? 38.62961 -0.28352  4.52303  0.571 27.79767  ? 172 LEU A CD2  1 
ATOM   2699 H HA   A LEU A 1 175 ? 40.71700 1.33529   3.95778  0.429 33.99054  ? 172 LEU A HA   1 
ATOM   2700 H HA   B LEU A 1 175 ? 40.75700 1.34412   3.91625  0.571 34.00929  ? 172 LEU A HA   1 
ATOM   2701 H HB2  A LEU A 1 175 ? 39.78115 1.86715   6.49984  0.429 32.60425  ? 172 LEU A HB2  1 
ATOM   2702 H HB2  B LEU A 1 175 ? 39.67317 2.27750   6.33120  0.571 32.25344  ? 172 LEU A HB2  1 
ATOM   2703 H HB3  A LEU A 1 175 ? 39.03932 2.63216   5.32091  0.429 32.60425  ? 172 LEU A HB3  1 
ATOM   2704 H HB3  B LEU A 1 175 ? 38.88699 2.32596   4.95099  0.571 32.25344  ? 172 LEU A HB3  1 
ATOM   2705 H HG   A LEU A 1 175 ? 38.23384 0.66107   4.49064  0.429 37.84801  ? 172 LEU A HG   1 
ATOM   2706 H HG   B LEU A 1 175 ? 39.56553 -0.05966  6.28204  0.571 32.84967  ? 172 LEU A HG   1 
ATOM   2707 H HD11 A LEU A 1 175 ? 38.64797 -1.37633  5.48320  0.429 38.34464  ? 172 LEU A HD11 1 
ATOM   2708 H HD11 B LEU A 1 175 ? 37.27791 -0.20187  6.79119  0.571 37.41711  ? 172 LEU A HD11 1 
ATOM   2709 H HD12 A LEU A 1 175 ? 39.98949 -0.74173  4.91654  0.429 38.34464  ? 172 LEU A HD12 1 
ATOM   2710 H HD12 B LEU A 1 175 ? 37.87649 1.13436   7.40739  0.571 37.41711  ? 172 LEU A HD12 1 
ATOM   2711 H HD13 A LEU A 1 175 ? 39.67817 -0.68192  6.47314  0.429 38.34464  ? 172 LEU A HD13 1 
ATOM   2712 H HD13 B LEU A 1 175 ? 37.02940 1.18877   6.06464  0.571 37.41711  ? 172 LEU A HD13 1 
ATOM   2713 H HD21 A LEU A 1 175 ? 36.83695 0.04920   6.29181  0.429 37.15904  ? 172 LEU A HD21 1 
ATOM   2714 H HD21 B LEU A 1 175 ? 38.23935 -1.14050  4.75583  0.571 33.31266  ? 172 LEU A HD21 1 
ATOM   2715 H HD22 A LEU A 1 175 ? 37.82105 0.78141   7.30123  0.429 37.15904  ? 172 LEU A HD22 1 
ATOM   2716 H HD22 B LEU A 1 175 ? 38.00472 0.22999   3.98757  0.571 33.31266  ? 172 LEU A HD22 1 
ATOM   2717 H HD23 A LEU A 1 175 ? 36.98712 1.63005   6.24867  0.429 37.15904  ? 172 LEU A HD23 1 
ATOM   2718 H HD23 B LEU A 1 175 ? 39.45427 -0.41847  4.03045  0.571 33.31266  ? 172 LEU A HD23 1 
ATOM   2719 N N    . ASN A 1 176 ? 41.74747 4.09034   5.24629  1.000 29.93111  ? 173 ASN A N    1 
ATOM   2720 C CA   . ASN A 1 176 ? 41.91243 5.51355   5.02473  1.000 30.70677  ? 173 ASN A CA   1 
ATOM   2721 C C    . ASN A 1 176 ? 43.35160 5.97255   4.91439  1.000 31.60693  ? 173 ASN A C    1 
ATOM   2722 O O    . ASN A 1 176 ? 43.57138 7.15710   4.65034  1.000 36.51571  ? 173 ASN A O    1 
ATOM   2723 C CB   . ASN A 1 176 ? 41.24647 6.31550   6.14789  1.000 29.23836  ? 173 ASN A CB   1 
ATOM   2724 C CG   . ASN A 1 176 ? 39.73346 6.27371   6.09908  1.000 39.47925  ? 173 ASN A CG   1 
ATOM   2725 O OD1  . ASN A 1 176 ? 39.12559 5.93610   5.08899  1.000 40.81911  ? 173 ASN A OD1  1 
ATOM   2726 N ND2  . ASN A 1 176 ? 39.11775 6.66170   7.19749  1.000 50.53106  ? 173 ASN A ND2  1 
ATOM   2727 H HA   . ASN A 1 176 ? 41.47022 5.72436   4.18752  1.000 36.80357  ? 173 ASN A HA   1 
ATOM   2728 H HB2  . ASN A 1 176 ? 41.52670 5.95146   7.00220  1.000 35.04148  ? 173 ASN A HB2  1 
ATOM   2729 H HB3  . ASN A 1 176 ? 41.52088 7.24313   6.07648  1.000 35.04148  ? 173 ASN A HB3  1 
ATOM   2730 H HD21 . ASN A 1 176 ? 39.57519 6.91611   7.87985  1.000 60.59272  ? 173 ASN A HD21 1 
ATOM   2731 H HD22 . ASN A 1 176 ? 38.25844 6.66052   7.23204  1.000 60.59272  ? 173 ASN A HD22 1 
ATOM   2732 N N    . GLY A 1 177 ? 44.32948 5.11953   5.16369  1.000 28.51894  ? 174 GLY A N    1 
ATOM   2733 C CA   . GLY A 1 177 ? 45.72491 5.47019   4.99625  1.000 31.62263  ? 174 GLY A CA   1 
ATOM   2734 C C    . GLY A 1 177 ? 46.43152 5.77471   6.30913  1.000 34.48516  ? 174 GLY A C    1 
ATOM   2735 O O    . GLY A 1 177 ? 45.82193 6.04105   7.34484  1.000 29.85080  ? 174 GLY A O    1 
ATOM   2736 H H    . GLY A 1 177 ? 44.20608 4.31353   5.43709  1.000 34.17818  ? 174 GLY A H    1 
ATOM   2737 H HA2  . GLY A 1 177 ? 46.18824 4.73326   4.56827  1.000 37.90261  ? 174 GLY A HA2  1 
ATOM   2738 H HA3  . GLY A 1 177 ? 45.78922 6.25514   4.43003  1.000 37.90261  ? 174 GLY A HA3  1 
ATOM   2739 N N    . LYS A 1 178 ? 47.76380 5.77250   6.22709  1.000 30.98177  ? 175 LYS A N    1 
ATOM   2740 C CA   . LYS A 1 178 ? 48.60900 5.96398   7.39720  1.000 33.18901  ? 175 LYS A CA   1 
ATOM   2741 C C    . LYS A 1 178 ? 48.46069 7.35017   8.00989  1.000 32.72926  ? 175 LYS A C    1 
ATOM   2742 O O    . LYS A 1 178 ? 48.59911 7.50632   9.22879  1.000 31.30294  ? 175 LYS A O    1 
ATOM   2743 C CB   . LYS A 1 178 ? 50.08596 5.76741   7.03209  1.000 36.65758  ? 175 LYS A CB   1 
ATOM   2744 C CG   . LYS A 1 178 ? 50.65495 4.39115   7.34084  1.000 67.10348  ? 175 LYS A CG   1 
ATOM   2745 C CD   . LYS A 1 178 ? 52.13233 4.29190   6.95377  1.000 97.28262  ? 175 LYS A CD   1 
ATOM   2746 C CE   . LYS A 1 178 ? 52.75367 2.94792   7.35162  1.000 95.13613  ? 175 LYS A CE   1 
ATOM   2747 N NZ   . LYS A 1 178 ? 52.22636 1.79030   6.57521  1.000 91.25537  ? 175 LYS A NZ   1 
ATOM   2748 H H    . LYS A 1 178 ? 48.20464 5.66086   5.49716  1.000 37.13357  ? 175 LYS A H    1 
ATOM   2749 H HA   . LYS A 1 178 ? 48.34001 5.29847   8.04961  1.000 39.78226  ? 175 LYS A HA   1 
ATOM   2750 H HB2  . LYS A 1 178 ? 50.18750 5.91537   6.07883  1.000 43.94454  ? 175 LYS A HB2  1 
ATOM   2751 H HB3  . LYS A 1 178 ? 50.61189 6.41554   7.52629  1.000 43.94454  ? 175 LYS A HB3  1 
ATOM   2752 H HG2  . LYS A 1 178 ? 50.57725 4.21786   8.29207  1.000 80.47962  ? 175 LYS A HG2  1 
ATOM   2753 H HG3  . LYS A 1 178 ? 50.16354 3.72114   6.84034  1.000 80.47962  ? 175 LYS A HG3  1 
ATOM   2754 H HD2  . LYS A 1 178 ? 52.21589 4.38892   5.99226  1.000 116.69460 ? 175 LYS A HD2  1 
ATOM   2755 H HD3  . LYS A 1 178 ? 52.62613 4.99601   7.40242  1.000 116.69460 ? 175 LYS A HD3  1 
ATOM   2756 H HE2  . LYS A 1 178 ? 53.71152 2.99067   7.20471  1.000 114.11881 ? 175 LYS A HE2  1 
ATOM   2757 H HE3  . LYS A 1 178 ? 52.56888 2.78355   8.28956  1.000 114.11881 ? 175 LYS A HE3  1 
ATOM   2758 H HZ1  . LYS A 1 178 ? 52.60825 1.03671   6.85516  1.000 109.46190 ? 175 LYS A HZ1  1 
ATOM   2759 H HZ2  . LYS A 1 178 ? 51.34553 1.72589   6.68517  1.000 109.46190 ? 175 LYS A HZ2  1 
ATOM   2760 H HZ3  . LYS A 1 178 ? 52.40219 1.89893   5.70954  1.000 109.46190 ? 175 LYS A HZ3  1 
ATOM   2761 N N    . GLU A 1 179 ? 48.22881 8.37757   7.19609  1.000 30.24879  ? 176 GLU A N    1 
ATOM   2762 C CA   . GLU A 1 179 ? 48.21137 9.72158   7.75436  1.000 30.70085  ? 176 GLU A CA   1 
ATOM   2763 C C    . GLU A 1 179 ? 46.97053 9.93736   8.62327  1.000 26.21880  ? 176 GLU A C    1 
ATOM   2764 O O    . GLU A 1 179 ? 47.06176 10.55653  9.67267  1.000 29.64783  ? 176 GLU A O    1 
ATOM   2765 C CB   . GLU A 1 179 ? 48.27380 10.75348  6.62347  1.000 39.26540  ? 176 GLU A CB   1 
ATOM   2766 C CG   . GLU A 1 179 ? 48.52536 12.15697  7.11790  1.000 77.03360  ? 176 GLU A CG   1 
ATOM   2767 C CD   . GLU A 1 179 ? 48.45932 13.18495  6.00540  1.000 105.23060 ? 176 GLU A CD   1 
ATOM   2768 O OE1  . GLU A 1 179 ? 47.72684 12.95669  5.01785  1.000 109.70320 ? 176 GLU A OE1  1 
ATOM   2769 O OE2  . GLU A 1 179 ? 49.14285 14.22408  6.11806  1.000 114.33818 ? 176 GLU A OE2  1 
ATOM   2770 H H    . GLU A 1 179 ? 48.08437 8.32393   6.35001  1.000 36.25400  ? 176 GLU A H    1 
ATOM   2771 H HA   . GLU A 1 179 ? 48.99316 9.84613   8.31488  1.000 36.79647  ? 176 GLU A HA   1 
ATOM   2772 H HB2  . GLU A 1 179 ? 48.99463 10.51525  6.01969  1.000 47.07393  ? 176 GLU A HB2  1 
ATOM   2773 H HB3  . GLU A 1 179 ? 47.42828 10.75076  6.14810  1.000 47.07393  ? 176 GLU A HB3  1 
ATOM   2774 H HG2  . GLU A 1 179 ? 47.85335 12.38540  7.77905  1.000 92.39577  ? 176 GLU A HG2  1 
ATOM   2775 H HG3  . GLU A 1 179 ? 49.40934 12.19955  7.51496  1.000 92.39577  ? 176 GLU A HG3  1 
ATOM   2776 N N    . VAL A 1 180 ? 45.80190 9.47705   8.16710  1.000 26.89044  ? 177 VAL A N    1 
ATOM   2777 C CA   . VAL A 1 180 ? 44.59256 9.57630   8.97956  1.000 24.46087  ? 177 VAL A CA   1 
ATOM   2778 C C    . VAL A 1 180 ? 44.75282 8.77665   10.27557 1.000 27.14511  ? 177 VAL A C    1 
ATOM   2779 O O    . VAL A 1 180 ? 44.34687 9.22437   11.34735 1.000 24.99220  ? 177 VAL A O    1 
ATOM   2780 C CB   . VAL A 1 180 ? 43.36847 9.09135   8.18659  1.000 25.71152  ? 177 VAL A CB   1 
ATOM   2781 C CG1  . VAL A 1 180 ? 42.15919 8.94797   9.07583  1.000 24.61603  ? 177 VAL A CG1  1 
ATOM   2782 C CG2  . VAL A 1 180 ? 43.05978 10.05739  7.03515  1.000 33.44262  ? 177 VAL A CG2  1 
ATOM   2783 H H    . VAL A 1 180 ? 45.68572 9.10755   7.39926  1.000 32.22398  ? 177 VAL A H    1 
ATOM   2784 H HA   . VAL A 1 180 ? 44.45873 10.50971  9.20699  1.000 29.30849  ? 177 VAL A HA   1 
ATOM   2785 H HB   . VAL A 1 180 ? 43.57482 8.21781   7.81884  1.000 30.80927  ? 177 VAL A HB   1 
ATOM   2786 H HG11 . VAL A 1 180 ? 41.40936 8.64150   8.54223  1.000 29.49468  ? 177 VAL A HG11 1 
ATOM   2787 H HG12 . VAL A 1 180 ? 42.35467 8.30259   9.77310  1.000 29.49468  ? 177 VAL A HG12 1 
ATOM   2788 H HG13 . VAL A 1 180 ? 41.95374 9.80972   9.47089  1.000 29.49468  ? 177 VAL A HG13 1 
ATOM   2789 H HG21 . VAL A 1 180 ? 42.29201 9.72699   6.54295  1.000 40.08659  ? 177 VAL A HG21 1 
ATOM   2790 H HG22 . VAL A 1 180 ? 42.86527 10.93404  7.40197  1.000 40.08659  ? 177 VAL A HG22 1 
ATOM   2791 H HG23 . VAL A 1 180 ? 43.83146 10.10763  6.44959  1.000 40.08659  ? 177 VAL A HG23 1 
ATOM   2792 N N    . ALA A 1 181 ? 45.33995 7.58297   10.20216 1.000 26.05675  ? 178 ALA A N    1 
ATOM   2793 C CA   . ALA A 1 181 ? 45.48741 6.77701   11.41746 1.000 24.27958  ? 178 ALA A CA   1 
ATOM   2794 C C    . ALA A 1 181 ? 46.39673 7.48190   12.41814 1.000 26.40138  ? 178 ALA A C    1 
ATOM   2795 O O    . ALA A 1 181 ? 46.15261 7.45133   13.63071 1.000 25.61764  ? 178 ALA A O    1 
ATOM   2796 C CB   . ALA A 1 181 ? 46.04838 5.38930   11.07840 1.000 30.90507  ? 178 ALA A CB   1 
ATOM   2797 H H    . ALA A 1 181 ? 45.65257 7.22550   9.48517  1.000 31.22356  ? 178 ALA A H    1 
ATOM   2798 H HA   . ALA A 1 181 ? 44.61320 6.65229   11.81883 1.000 29.09095  ? 178 ALA A HA   1 
ATOM   2799 H HB1  . ALA A 1 181 ? 46.12447 4.87129   11.89496 1.000 37.04154  ? 178 ALA A HB1  1 
ATOM   2800 H HB2  . ALA A 1 181 ? 45.44496 4.94694   10.46107 1.000 37.04154  ? 178 ALA A HB2  1 
ATOM   2801 H HB3  . ALA A 1 181 ? 46.92202 5.49302   10.66986 1.000 37.04154  ? 178 ALA A HB3  1 
ATOM   2802 N N    . ALA A 1 182 ? 47.44232 8.16578   11.92032 1.000 25.22732  ? 179 ALA A N    1 
ATOM   2803 C CA   . ALA A 1 182 ? 48.33192 8.85870   12.83212 1.000 24.61267  ? 179 ALA A CA   1 
ATOM   2804 C C    . ALA A 1 182 ? 47.63419 10.05938  13.45803 1.000 24.78017  ? 179 ALA A C    1 
ATOM   2805 O O    . ALA A 1 182 ? 47.86249 10.36845  14.63657 1.000 25.50225  ? 179 ALA A O    1 
ATOM   2806 C CB   . ALA A 1 182 ? 49.59891 9.29284   12.10254 1.000 29.31058  ? 179 ALA A CB   1 
ATOM   2807 H H    . ALA A 1 182 ? 47.64190 8.23489   11.08666 1.000 30.22824  ? 179 ALA A H    1 
ATOM   2808 H HA   . ALA A 1 182 ? 48.59339 8.25216   13.54251 1.000 29.49065  ? 179 ALA A HA   1 
ATOM   2809 H HB1  . ALA A 1 182 ? 50.16339 9.78751   12.71700 1.000 35.12815  ? 179 ALA A HB1  1 
ATOM   2810 H HB2  . ALA A 1 182 ? 50.06661 8.50443   11.78543 1.000 35.12815  ? 179 ALA A HB2  1 
ATOM   2811 H HB3  . ALA A 1 182 ? 49.35378 9.85628   11.35197 1.000 35.12815  ? 179 ALA A HB3  1 
ATOM   2812 N N    . GLN A 1 183 ? 46.80578 10.76615  12.67455 1.000 22.53337  ? 180 GLN A N    1 
ATOM   2813 C CA   A GLN A 1 183 ? 46.05134 11.91916  13.17650 0.582 23.88094  ? 180 GLN A CA   1 
ATOM   2814 C CA   B GLN A 1 183 ? 46.10890 11.92239  13.23271 0.418 23.85126  ? 180 GLN A CA   1 
ATOM   2815 C C    . GLN A 1 183 ? 45.04733 11.51419  14.26024 1.000 20.35182  ? 180 GLN A C    1 
ATOM   2816 O O    . GLN A 1 183 ? 44.84339 12.23300  15.24365 1.000 24.35292  ? 180 GLN A O    1 
ATOM   2817 C CB   A GLN A 1 183 ? 45.29860 12.58276  12.01214 0.582 25.25922  ? 180 GLN A CB   1 
ATOM   2818 C CB   B GLN A 1 183 ? 45.48921 12.75632  12.11033 0.418 29.47646  ? 180 GLN A CB   1 
ATOM   2819 C CG   A GLN A 1 183 ? 46.17807 13.17579  10.88714 0.582 32.70290  ? 180 GLN A CG   1 
ATOM   2820 C CG   B GLN A 1 183 ? 46.46573 13.75203  11.44968 0.418 30.96604  ? 180 GLN A CG   1 
ATOM   2821 C CD   A GLN A 1 183 ? 45.36743 13.61371  9.65497  0.582 30.20741  ? 180 GLN A CD   1 
ATOM   2822 C CD   B GLN A 1 183 ? 47.05309 14.77221  12.42704 0.418 41.82167  ? 180 GLN A CD   1 
ATOM   2823 O OE1  A GLN A 1 183 ? 44.16915 13.31114  9.52496  0.582 31.76129  ? 180 GLN A OE1  1 
ATOM   2824 O OE1  B GLN A 1 183 ? 46.35413 15.66358  12.92304 0.418 37.98469  ? 180 GLN A OE1  1 
ATOM   2825 N NE2  A GLN A 1 183 ? 46.03026 14.32442  8.73965  0.582 43.95016  ? 180 GLN A NE2  1 
ATOM   2826 N NE2  B GLN A 1 183 ? 48.35018 14.65460  12.68903 0.418 44.65403  ? 180 GLN A NE2  1 
ATOM   2827 H HB2  A GLN A 1 183 ? 44.72272 11.91692  11.60482 0.582 30.26652  ? 180 GLN A HB2  1 
ATOM   2828 H HB2  B GLN A 1 183 ? 45.16823 12.15629  11.41908 0.418 35.32721  ? 180 GLN A HB2  1 
ATOM   2829 H HB3  A GLN A 1 183 ? 44.76442 13.30856  12.37099 0.582 30.26652  ? 180 GLN A HB3  1 
ATOM   2830 H HB3  B GLN A 1 183 ? 44.75003 13.26736  12.47550 0.418 35.32721  ? 180 GLN A HB3  1 
ATOM   2831 H HG2  A GLN A 1 183 ? 46.64469 13.95420  11.22955 0.582 39.19892  ? 180 GLN A HG2  1 
ATOM   2832 H HG2  B GLN A 1 183 ? 47.20278 13.25598  11.06033 0.418 37.11470  ? 180 GLN A HG2  1 
ATOM   2833 H HG3  A GLN A 1 183 ? 46.81756 12.50501  10.60077 0.582 39.19892  ? 180 GLN A HG3  1 
ATOM   2834 H HG3  B GLN A 1 183 ? 45.99339 14.24165  10.75826 0.418 37.11470  ? 180 GLN A HG3  1 
ATOM   2835 H HE21 A GLN A 1 183 ? 46.86119 14.51113  8.85918  0.582 52.69564  ? 180 GLN A HE21 1 
ATOM   2836 H HE21 B GLN A 1 183 ? 48.80938 14.03052  12.31584 0.418 53.54028  ? 180 GLN A HE21 1 
ATOM   2837 H HE22 A GLN A 1 183 ? 45.62631 14.59554  8.03048  0.582 52.69564  ? 180 GLN A HE22 1 
ATOM   2838 H HE22 B GLN A 1 183 ? 48.73064 15.20254  13.23180 0.418 53.54028  ? 180 GLN A HE22 1 
ATOM   2839 N N    . VAL A 1 184 ? 44.37682 10.37524  14.06247 1.000 21.11612  ? 181 VAL A N    1 
ATOM   2840 C CA   . VAL A 1 184 ? 43.39770 9.87178   15.03085 1.000 22.04721  ? 181 VAL A CA   1 
ATOM   2841 C C    . VAL A 1 184 ? 44.07898 9.37564   16.29997 1.000 22.88427  ? 181 VAL A C    1 
ATOM   2842 O O    . VAL A 1 184 ? 43.54013 9.49620   17.39591 1.000 23.83854  ? 181 VAL A O    1 
ATOM   2843 C CB   . VAL A 1 184 ? 42.58064 8.74607   14.37329 1.000 25.00512  ? 181 VAL A CB   1 
ATOM   2844 C CG1  . VAL A 1 184 ? 41.79093 7.95712   15.40535 1.000 30.06792  ? 181 VAL A CG1  1 
ATOM   2845 C CG2  . VAL A 1 184 ? 41.67672 9.35564   13.32737 1.000 33.39735  ? 181 VAL A CG2  1 
ATOM   2846 H H    . VAL A 1 184 ? 44.47017 9.87132   13.37186 1.000 25.29480  ? 181 VAL A H    1 
ATOM   2847 H HA   . VAL A 1 184 ? 42.80909 10.60038  15.28300 1.000 26.41211  ? 181 VAL A HA   1 
ATOM   2848 H HB   . VAL A 1 184 ? 43.17694 8.11080   13.94695 1.000 29.96159  ? 181 VAL A HB   1 
ATOM   2849 H HG11 . VAL A 1 184 ? 41.28115 7.26698   14.95289 1.000 36.03696  ? 181 VAL A HG11 1 
ATOM   2850 H HG12 . VAL A 1 184 ? 42.40885 7.55311   16.03452 1.000 36.03696  ? 181 VAL A HG12 1 
ATOM   2851 H HG13 . VAL A 1 184 ? 41.19067 8.55962   15.87180 1.000 36.03696  ? 181 VAL A HG13 1 
ATOM   2852 H HG21 . VAL A 1 184 ? 41.16062 8.65051   12.90626 1.000 40.03227  ? 181 VAL A HG21 1 
ATOM   2853 H HG22 . VAL A 1 184 ? 41.08146 9.99056   13.75567 1.000 40.03227  ? 181 VAL A HG22 1 
ATOM   2854 H HG23 . VAL A 1 184 ? 42.22124 9.80811   12.66430 1.000 40.03227  ? 181 VAL A HG23 1 
ATOM   2855 N N    . LYS A 1 185 ? 45.25221 8.77641   16.15163 1.000 19.79153  ? 182 LYS A N    1 
ATOM   2856 C CA   . LYS A 1 185 ? 45.98705 8.23131   17.28475 1.000 18.44467  ? 182 LYS A CA   1 
ATOM   2857 C C    . LYS A 1 185 ? 46.42114 9.29528   18.28165 1.000 23.93793  ? 182 LYS A C    1 
ATOM   2858 O O    . LYS A 1 185 ? 46.40004 9.05190   19.48342 1.000 22.26015  ? 182 LYS A O    1 
ATOM   2859 C CB   . LYS A 1 185 ? 47.22290 7.47904   16.73406 1.000 22.77611  ? 182 LYS A CB   1 
ATOM   2860 C CG   . LYS A 1 185 ? 48.05310 6.80280   17.81949 1.000 30.99447  ? 182 LYS A CG   1 
ATOM   2861 C CD   . LYS A 1 185 ? 49.24562 6.04657   17.19060 1.000 34.44138  ? 182 LYS A CD   1 
ATOM   2862 C CE   . LYS A 1 185 ? 50.06056 5.41866   18.30734 1.000 53.01364  ? 182 LYS A CE   1 
ATOM   2863 N NZ   . LYS A 1 185 ? 51.30162 4.71106   17.87962 1.000 55.66913  ? 182 LYS A NZ   1 
ATOM   2864 H H    . LYS A 1 185 ? 45.65111 8.67016   15.39719 1.000 23.70529  ? 182 LYS A H    1 
ATOM   2865 H HA   . LYS A 1 185 ? 45.40834 7.62299   17.77049 1.000 22.08906  ? 182 LYS A HA   1 
ATOM   2866 H HB2  . LYS A 1 185 ? 46.92286 6.79270   16.11776 1.000 27.28678  ? 182 LYS A HB2  1 
ATOM   2867 H HB3  . LYS A 1 185 ? 47.79500 8.11209   16.27269 1.000 27.28678  ? 182 LYS A HB3  1 
ATOM   2868 H HG2  . LYS A 1 185 ? 48.39840 7.47260   18.43026 1.000 37.14881  ? 182 LYS A HG2  1 
ATOM   2869 H HG3  . LYS A 1 185 ? 47.50238 6.16644   18.30183 1.000 37.14881  ? 182 LYS A HG3  1 
ATOM   2870 H HD2  . LYS A 1 185 ? 48.92253 5.34699   16.60145 1.000 41.28510  ? 182 LYS A HD2  1 
ATOM   2871 H HD3  . LYS A 1 185 ? 49.80736 6.66363   16.69604 1.000 41.28510  ? 182 LYS A HD3  1 
ATOM   2872 H HE2  . LYS A 1 185 ? 50.32680 6.11982   18.92248 1.000 63.57182  ? 182 LYS A HE2  1 
ATOM   2873 H HE3  . LYS A 1 185 ? 49.50290 4.77010   18.76481 1.000 63.57182  ? 182 LYS A HE3  1 
ATOM   2874 H HZ1  . LYS A 1 185 ? 51.72554 4.38348   18.59031 1.000 66.75840  ? 182 LYS A HZ1  1 
ATOM   2875 H HZ2  . LYS A 1 185 ? 51.09624 4.04069   17.33143 1.000 66.75840  ? 182 LYS A HZ2  1 
ATOM   2876 H HZ3  . LYS A 1 185 ? 51.84305 5.27571   17.45521 1.000 66.75840  ? 182 LYS A HZ3  1 
ATOM   2877 N N    . ALA A 1 186 ? 46.85162 10.46456  17.81692 1.000 22.79007  ? 183 ALA A N    1 
ATOM   2878 C CA   . ALA A 1 186 ? 47.54466 11.38141  18.71448 1.000 22.90095  ? 183 ALA A CA   1 
ATOM   2879 C C    . ALA A 1 186 ? 46.71310 11.82164  19.90659 1.000 25.47378  ? 183 ALA A C    1 
ATOM   2880 O O    . ALA A 1 186 ? 47.25829 11.81798  21.02490 1.000 28.64491  ? 183 ALA A O    1 
ATOM   2881 C CB   . ALA A 1 186 ? 48.07357 12.58835  17.93395 1.000 30.12012  ? 183 ALA A CB   1 
ATOM   2882 H H    . ALA A 1 186 ? 46.75814 10.74392  17.00894 1.000 27.30354  ? 183 ALA A H    1 
ATOM   2883 H HA   . ALA A 1 186 ? 48.30877 10.90109  19.06991 1.000 27.43658  ? 183 ALA A HA   1 
ATOM   2884 H HB1  . ALA A 1 186 ? 48.52861 13.18635  18.54733 1.000 36.09960  ? 183 ALA A HB1  1 
ATOM   2885 H HB2  . ALA A 1 186 ? 48.69218 12.27837  17.25415 1.000 36.09960  ? 183 ALA A HB2  1 
ATOM   2886 H HB3  . ALA A 1 186 ? 47.32710 13.04693  17.51755 1.000 36.09960  ? 183 ALA A HB3  1 
ATOM   2887 N N    . PRO A 1 187 ? 45.43418 12.19208  19.77296 1.000 23.04558  ? 184 PRO A N    1 
ATOM   2888 C CA   . PRO A 1 187 ? 44.66379 12.62261  20.95469 1.000 22.47217  ? 184 PRO A CA   1 
ATOM   2889 C C    . PRO A 1 187 ? 44.26982 11.47739  21.88477 1.000 23.65771  ? 184 PRO A C    1 
ATOM   2890 O O    . PRO A 1 187 ? 43.67269 11.71835  22.92894 1.000 24.44822  ? 184 PRO A O    1 
ATOM   2891 C CB   . PRO A 1 187 ? 43.38615 13.27472  20.34194 1.000 28.19959  ? 184 PRO A CB   1 
ATOM   2892 C CG   . PRO A 1 187 ? 43.67793 13.43062  18.88757 1.000 30.31441  ? 184 PRO A CG   1 
ATOM   2893 C CD   . PRO A 1 187 ? 44.67823 12.36890  18.52455 1.000 25.99655  ? 184 PRO A CD   1 
ATOM   2894 H HA   . PRO A 1 187 ? 45.16630 13.29239  21.44436 1.000 26.92206  ? 184 PRO A HA   1 
ATOM   2895 H HB2  . PRO A 1 187 ? 42.62213 12.69340  20.48064 1.000 33.79496  ? 184 PRO A HB2  1 
ATOM   2896 H HB3  . PRO A 1 187 ? 43.22657 14.13696  20.75664 1.000 33.79496  ? 184 PRO A HB3  1 
ATOM   2897 H HG2  . PRO A 1 187 ? 42.85961 13.31374  18.38004 1.000 36.33274  ? 184 PRO A HG2  1 
ATOM   2898 H HG3  . PRO A 1 187 ? 44.04582 14.31333  18.72517 1.000 36.33274  ? 184 PRO A HG3  1 
ATOM   2899 H HD2  . PRO A 1 187 ? 44.23325 11.54581  18.26881 1.000 31.15131  ? 184 PRO A HD2  1 
ATOM   2900 H HD3  . PRO A 1 187 ? 45.25814 12.66921  17.80732 1.000 31.15131  ? 184 PRO A HD3  1 
ATOM   2901 N N    . LEU A 1 188 ? 44.55710 10.22983  21.54818 1.000 21.83467  ? 185 LEU A N    1 
ATOM   2902 C CA   . LEU A 1 188 ? 44.14580 9.13221   22.41410 1.000 23.77739  ? 185 LEU A CA   1 
ATOM   2903 C C    . LEU A 1 188 ? 45.07005 8.94929   23.60388 1.000 26.19256  ? 185 LEU A C    1 
ATOM   2904 O O    . LEU A 1 188 ? 44.67915 8.30218   24.57808 1.000 23.88306  ? 185 LEU A O    1 
ATOM   2905 C CB   . LEU A 1 188 ? 44.10101 7.82395   21.63204 1.000 24.12535  ? 185 LEU A CB   1 
ATOM   2906 C CG   . LEU A 1 188 ? 43.13649 7.82016   20.44118 1.000 20.34808  ? 185 LEU A CG   1 
ATOM   2907 C CD1  . LEU A 1 188 ? 43.25871 6.49419   19.70344 1.000 27.02410  ? 185 LEU A CD1  1 
ATOM   2908 C CD2  . LEU A 1 188 ? 41.71447 8.00651   20.87286 1.000 24.65523  ? 185 LEU A CD2  1 
ATOM   2909 H H    . LEU A 1 188 ? 44.98092 9.99439   20.83786 1.000 26.15705  ? 185 LEU A H    1 
ATOM   2910 H HA   . LEU A 1 188 ? 43.25286 9.32592   22.73975 1.000 28.48831  ? 185 LEU A HA   1 
ATOM   2911 H HB2  . LEU A 1 188 ? 44.98965 7.64046   21.28919 1.000 28.90587  ? 185 LEU A HB2  1 
ATOM   2912 H HB3  . LEU A 1 188 ? 43.82491 7.11540   22.23423 1.000 28.90587  ? 185 LEU A HB3  1 
ATOM   2913 H HG   . LEU A 1 188 ? 43.36816 8.55891   19.85682 1.000 24.37314  ? 185 LEU A HG   1 
ATOM   2914 H HD11 . LEU A 1 188 ? 42.65904 6.50054   18.94104 1.000 32.38437  ? 185 LEU A HD11 1 
ATOM   2915 H HD12 . LEU A 1 188 ? 44.17435 6.38310   19.40316 1.000 32.38437  ? 185 LEU A HD12 1 
ATOM   2916 H HD13 . LEU A 1 188 ? 43.01881 5.77371   20.30698 1.000 32.38437  ? 185 LEU A HD13 1 
ATOM   2917 H HD21 . LEU A 1 188 ? 41.14979 8.05869   20.08589 1.000 29.54172  ? 185 LEU A HD21 1 
ATOM   2918 H HD22 . LEU A 1 188 ? 41.44923 7.25132   21.42081 1.000 29.54172  ? 185 LEU A HD22 1 
ATOM   2919 H HD23 . LEU A 1 188 ? 41.64488 8.82738   21.38494 1.000 29.54172  ? 185 LEU A HD23 1 
ATOM   2920 N N    . VAL A 1 189 ? 46.27921 9.49029   23.54346 1.000 23.83538  ? 186 VAL A N    1 
ATOM   2921 C CA   . VAL A 1 189 ? 47.28579 9.30643   24.59178 1.000 20.84577  ? 186 VAL A CA   1 
ATOM   2922 C C    . VAL A 1 189 ? 47.65617 7.82800   24.73435 1.000 23.35213  ? 186 VAL A C    1 
ATOM   2923 O O    . VAL A 1 189 ? 47.67567 7.25810   25.83132 1.000 23.48948  ? 186 VAL A O    1 
ATOM   2924 C CB   . VAL A 1 189 ? 46.86600 9.90083   25.95988 1.000 23.51139  ? 186 VAL A CB   1 
ATOM   2925 C CG1  . VAL A 1 189 ? 48.09540 10.16786  26.81670 1.000 28.02882  ? 186 VAL A CG1  1 
ATOM   2926 C CG2  . VAL A 1 189 ? 46.10730 11.19167  25.80117 1.000 26.25601  ? 186 VAL A CG2  1 
ATOM   2927 H H    . VAL A 1 189 ? 46.55204 9.98070   22.89180 1.000 28.55790  ? 186 VAL A H    1 
ATOM   2928 H HA   . VAL A 1 189 ? 48.07383 9.78891   24.29663 1.000 24.97038  ? 186 VAL A HA   1 
ATOM   2929 H HB   . VAL A 1 189 ? 46.28811 9.25278   26.39228 1.000 28.16912  ? 186 VAL A HB   1 
ATOM   2930 H HG11 . VAL A 1 189 ? 47.81196 10.52260  27.67385 1.000 33.59003  ? 186 VAL A HG11 1 
ATOM   2931 H HG12 . VAL A 1 189 ? 48.57702 9.33585   26.94596 1.000 33.59003  ? 186 VAL A HG12 1 
ATOM   2932 H HG13 . VAL A 1 189 ? 48.66243 10.81133  26.36357 1.000 33.59003  ? 186 VAL A HG13 1 
ATOM   2933 H HG21 . VAL A 1 189 ? 45.87604 11.53209  26.67954 1.000 31.46267  ? 186 VAL A HG21 1 
ATOM   2934 H HG22 . VAL A 1 189 ? 46.66746 11.83198  25.33521 1.000 31.46267  ? 186 VAL A HG22 1 
ATOM   2935 H HG23 . VAL A 1 189 ? 45.30102 11.02315  25.28892 1.000 31.46267  ? 186 VAL A HG23 1 
ATOM   2936 N N    . LEU A 1 190 ? 47.96066 7.18476   23.61350 1.000 23.64051  ? 187 LEU A N    1 
ATOM   2937 C CA   . LEU A 1 190 ? 48.48709 5.83198   23.66711 1.000 22.55552  ? 187 LEU A CA   1 
ATOM   2938 C C    . LEU A 1 190 ? 49.96436 5.84869   24.02583 1.000 34.35665  ? 187 LEU A C    1 
ATOM   2939 O O    . LEU A 1 190 ? 50.67508 6.81647   23.75978 1.000 38.69129  ? 187 LEU A O    1 
ATOM   2940 C CB   . LEU A 1 190 ? 48.30243 5.12267   22.32576 1.000 25.03504  ? 187 LEU A CB   1 
ATOM   2941 C CG   . LEU A 1 190 ? 46.85144 4.75825   22.07350 1.000 31.81329  ? 187 LEU A CG   1 
ATOM   2942 C CD1  . LEU A 1 190 ? 46.65480 4.39213   20.63150 1.000 34.33237  ? 187 LEU A CD1  1 
ATOM   2943 C CD2  . LEU A 1 190 ? 46.45816 3.62618   22.97258 1.000 31.39471  ? 187 LEU A CD2  1 
ATOM   2944 H H    . LEU A 1 190 ? 47.87204 7.50720   22.82118 1.000 28.32406  ? 187 LEU A H    1 
ATOM   2945 H HA   . LEU A 1 190 ? 48.00578 5.33206   24.34484 1.000 27.02207  ? 187 LEU A HA   1 
ATOM   2946 H HB2  . LEU A 1 190 ? 48.59768 5.70945   21.61202 1.000 29.99750  ? 187 LEU A HB2  1 
ATOM   2947 H HB3  . LEU A 1 190 ? 48.82654 4.30646   22.32242 1.000 29.99750  ? 187 LEU A HB3  1 
ATOM   2948 H HG   . LEU A 1 190 ? 46.27797 5.51636   22.26662 1.000 38.13140  ? 187 LEU A HG   1 
ATOM   2949 H HD11 . LEU A 1 190 ? 45.72166 4.17058   20.48634 1.000 41.15429  ? 187 LEU A HD11 1 
ATOM   2950 H HD12 . LEU A 1 190 ? 46.90561 5.14738   20.07689 1.000 41.15429  ? 187 LEU A HD12 1 
ATOM   2951 H HD13 . LEU A 1 190 ? 47.21299 3.62729   20.42091 1.000 41.15429  ? 187 LEU A HD13 1 
ATOM   2952 H HD21 . LEU A 1 190 ? 45.55170 3.35419   22.75984 1.000 37.62910  ? 187 LEU A HD21 1 
ATOM   2953 H HD22 . LEU A 1 190 ? 47.06761 2.88478   22.83188 1.000 37.62910  ? 187 LEU A HD22 1 
ATOM   2954 H HD23 . LEU A 1 190 ? 46.50648 3.92369   23.89456 1.000 37.62910  ? 187 LEU A HD23 1 
ATOM   2955 N N    . LYS A 1 191 ? 50.41317 4.76969   24.65857 1.000 40.32496  ? 188 LYS A N    1 
ATOM   2956 C CA   . LYS A 1 191 ? 51.82315 4.65901   25.03144 1.000 52.42399  ? 188 LYS A CA   1 
ATOM   2957 C C    . LYS A 1 191 ? 52.69377 4.48454   23.79126 1.000 57.70926  ? 188 LYS A C    1 
ATOM   2958 O O    . LYS A 1 191 ? 53.58712 5.29781   23.51997 1.000 66.24857  ? 188 LYS A O    1 
ATOM   2959 C CB   . LYS A 1 191 ? 52.00256 3.48950   26.01142 1.000 46.40622  ? 188 LYS A CB   1 
ATOM   2960 C CG   . LYS A 1 191 ? 53.41382 3.29236   26.55649 1.000 73.88078  ? 188 LYS A CG   1 
ATOM   2961 C CD   . LYS A 1 191 ? 53.77562 4.36849   27.57952 1.000 83.35313  ? 188 LYS A CD   1 
ATOM   2962 C CE   . LYS A 1 191 ? 55.20587 4.23377   28.09692 1.000 93.83888  ? 188 LYS A CE   1 
ATOM   2963 N NZ   . LYS A 1 191 ? 55.51291 5.26276   29.13574 1.000 89.26534  ? 188 LYS A NZ   1 
ATOM   2964 H H    . LYS A 1 191 ? 49.92996 4.09430   24.88208 1.000 48.34540  ? 188 LYS A H    1 
ATOM   2965 H HA   . LYS A 1 191 ? 52.10754 5.47016   25.48095 1.000 62.86424  ? 188 LYS A HA   1 
ATOM   2966 H HB2  . LYS A 1 191 ? 51.41864 3.63754   26.77170 1.000 55.64291  ? 188 LYS A HB2  1 
ATOM   2967 H HB3  . LYS A 1 191 ? 51.75303 2.67019   25.55604 1.000 55.64291  ? 188 LYS A HB3  1 
ATOM   2968 H HG2  . LYS A 1 191 ? 53.47235 2.42704   26.99088 1.000 88.61238  ? 188 LYS A HG2  1 
ATOM   2969 H HG3  . LYS A 1 191 ? 54.04995 3.34046   25.82578 1.000 88.61238  ? 188 LYS A HG3  1 
ATOM   2970 H HD2  . LYS A 1 191 ? 53.68774 5.24126   27.16545 1.000 99.97921  ? 188 LYS A HD2  1 
ATOM   2971 H HD3  . LYS A 1 191 ? 53.17485 4.29909   28.33792 1.000 99.97921  ? 188 LYS A HD3  1 
ATOM   2972 H HE2  . LYS A 1 191 ? 55.32242 3.35619   28.49336 1.000 112.56210 ? 188 LYS A HE2  1 
ATOM   2973 H HE3  . LYS A 1 191 ? 55.82598 4.34999   27.36013 1.000 112.56210 ? 188 LYS A HE3  1 
ATOM   2974 H HZ1  . LYS A 1 191 ? 56.35387 5.17373   29.41316 1.000 107.07386 ? 188 LYS A HZ1  1 
ATOM   2975 H HZ2  . LYS A 1 191 ? 55.40533 6.07874   28.79707 1.000 107.07386 ? 188 LYS A HZ2  1 
ATOM   2976 H HZ3  . LYS A 1 191 ? 54.96719 5.16473   29.83193 1.000 107.07386 ? 188 LYS A HZ3  1 
ATOM   2977 N N    . ASP A 1 192 ? 52.43498 3.44609   23.00341 1.000 46.86638  ? 189 ASP A N    1 
ATOM   2978 C CA   . ASP A 1 192 ? 53.27813 3.24787   21.82511 1.000 89.84203  ? 189 ASP A CA   1 
ATOM   2979 C C    . ASP A 1 192 ? 52.43200 3.03266   20.58313 1.000 93.00420  ? 189 ASP A C    1 
ATOM   2980 O O    . ASP A 1 192 ? 51.83755 1.97165   20.41445 1.000 108.74866 ? 189 ASP A O    1 
ATOM   2981 C CB   . ASP A 1 192 ? 54.22518 2.06012   22.03457 1.000 84.31601  ? 189 ASP A CB   1 
ATOM   2982 C CG   . ASP A 1 192 ? 55.22880 2.30219   23.15331 1.000 91.10907  ? 189 ASP A CG   1 
ATOM   2983 O OD1  . ASP A 1 192 ? 55.89345 3.36099   23.15557 1.000 98.23404  ? 189 ASP A OD1  1 
ATOM   2984 O OD2  . ASP A 1 192 ? 55.34710 1.42569   24.03783 1.000 95.34871  ? 189 ASP A OD2  1 
ATOM   2985 H H    . ASP A 1 192 ? 50.11167 1.76207   23.55150 1.000 0.22439   ? 189 ASP A H    1 
ATOM   2986 H HA   . ASP A 1 192 ? 54.64546 5.65586   21.32226 1.000 0.22449   ? 189 ASP A HA   1 
ATOM   2987 H HB2  . ASP A 1 192 ? 52.40746 -0.36634  22.39711 1.000 0.22448   ? 189 ASP A HB2  1 
ATOM   2988 H HB3  . ASP A 1 192 ? 55.55819 0.73297   19.51860 1.000 0.22448   ? 189 ASP A HB3  1 
HETATM 2989 O O    . HOH B 2 .   ? 33.083   -20.778   26.537   1.000 49.03707  ? 201 HOH A O    1 
HETATM 2990 O O    . HOH B 2 .   ? 51.54879 -16.46914 22.52120 1.000 56.24903  ? 202 HOH A O    1 
HETATM 2991 O O    . HOH B 2 .   ? 34.66197 -19.52355 21.14146 1.000 52.65031  ? 203 HOH A O    1 
HETATM 2992 O O    . HOH B 2 .   ? 44.52421 -13.84334 3.27882  1.000 45.68955  ? 204 HOH A O    1 
HETATM 2993 O O    . HOH B 2 .   ? 29.081   -13.363   31.185   1.000 51.35820  ? 205 HOH A O    1 
HETATM 2994 O O    . HOH B 2 .   ? 51.06084 9.17134   24.61370 1.000 55.14506  ? 206 HOH A O    1 
HETATM 2995 O O    . HOH B 2 .   ? 50.83105 -3.94852  17.19365 1.000 47.51975  ? 207 HOH A O    1 
HETATM 2996 O O    . HOH B 2 .   ? 30.12845 -6.36441  2.87585  1.000 48.08904  ? 208 HOH A O    1 
HETATM 2997 O O    . HOH B 2 .   ? 16.97784 -2.65654  12.15370 1.000 41.62740  ? 209 HOH A O    1 
HETATM 2998 O O    . HOH B 2 .   ? 47.58090 -25.48149 18.50121 1.000 37.50114  ? 210 HOH A O    1 
HETATM 2999 O O    . HOH B 2 .   ? 32.21709 2.68351   0.74269  1.000 52.50112  ? 211 HOH A O    1 
HETATM 3000 O O    . HOH B 2 .   ? 21.68811 -15.65627 12.63258 1.000 48.98899  ? 212 HOH A O    1 
HETATM 3001 O O    . HOH B 2 .   ? 37.86450 -3.25088  1.72517  1.000 38.59167  ? 213 HOH A O    1 
HETATM 3002 O O    . HOH B 2 .   ? 30.62022 -24.88524 10.54976 1.000 61.05316  ? 214 HOH A O    1 
HETATM 3003 O O    . HOH B 2 .   ? 43.13121 -26.30030 4.04652  1.000 32.46584  ? 215 HOH A O    1 
HETATM 3004 O O    . HOH B 2 .   ? 33.94149 -20.08165 18.45556 1.000 35.53011  ? 216 HOH A O    1 
HETATM 3005 O O    . HOH B 2 .   ? 23.93994 -17.93175 16.32935 1.000 40.53533  ? 217 HOH A O    1 
HETATM 3006 O O    . HOH B 2 .   ? 25.96196 -12.29274 27.99249 1.000 43.89386  ? 218 HOH A O    1 
HETATM 3007 O O    . HOH B 2 .   ? 49.34899 -24.42381 8.69080  1.000 31.63649  ? 219 HOH A O    1 
HETATM 3008 O O    . HOH B 2 .   ? 45.71662 8.78492   5.03832  1.000 37.77138  ? 220 HOH A O    1 
HETATM 3009 O O    . HOH B 2 .   ? 27.25059 -7.98845  36.77552 1.000 50.45013  ? 221 HOH A O    1 
HETATM 3010 O O    . HOH B 2 .   ? 45.39384 -12.39021 9.83646  1.000 22.22128  ? 222 HOH A O    1 
HETATM 3011 O O    . HOH B 2 .   ? 38.66858 -28.06354 11.32784 1.000 44.82244  ? 223 HOH A O    1 
HETATM 3012 O O    . HOH B 2 .   ? 46.621   -28.325   14.373   1.000 30.06113  ? 224 HOH A O    1 
HETATM 3013 O O    . HOH B 2 .   ? 26.13485 3.00229   17.89266 1.000 28.64936  ? 225 HOH A O    1 
HETATM 3014 O O    . HOH B 2 .   ? 44.20831 -28.01499 17.19208 1.000 36.55838  ? 226 HOH A O    1 
HETATM 3015 O O    . HOH B 2 .   ? 50.21265 -18.33685 21.56641 1.000 41.22617  ? 227 HOH A O    1 
HETATM 3016 O O    . HOH B 2 .   ? 31.78016 -11.83738 19.37247 1.000 24.43978  ? 228 HOH A O    1 
HETATM 3017 O O    . HOH B 2 .   ? 25.54290 1.38328   20.21879 1.000 30.03467  ? 229 HOH A O    1 
HETATM 3018 O O    . HOH B 2 .   ? 35.16044 -25.66346 9.35791  1.000 44.80433  ? 230 HOH A O    1 
HETATM 3019 O O    . HOH B 2 .   ? 45.82209 14.79799  15.60173 1.000 33.76310  ? 231 HOH A O    1 
HETATM 3020 O O    . HOH B 2 .   ? 38.98372 -17.46478 26.96284 1.000 48.45644  ? 232 HOH A O    1 
HETATM 3021 O O    . HOH B 2 .   ? 28.54974 -23.18037 11.35351 1.000 48.14917  ? 233 HOH A O    1 
HETATM 3022 O O    . HOH B 2 .   ? 20.50137 -13.25637 12.30843 1.000 54.12114  ? 234 HOH A O    1 
HETATM 3023 O O    . HOH B 2 .   ? 33.86101 -17.01898 -0.84146 1.000 60.21240  ? 235 HOH A O    1 
HETATM 3024 O O    . HOH B 2 .   ? 50.32953 10.01720  15.86895 1.000 40.27347  ? 236 HOH A O    1 
HETATM 3025 O O    . HOH B 2 .   ? 48.05648 -0.69354  14.42237 1.000 34.78551  ? 237 HOH A O    1 
HETATM 3026 O O    . HOH B 2 .   ? 48.55089 8.64790   21.31261 1.000 30.35794  ? 238 HOH A O    1 
HETATM 3027 O O    . HOH B 2 .   ? 22.56267 2.72446   18.61023 1.000 41.76672  ? 239 HOH A O    1 
HETATM 3028 O O    . HOH B 2 .   ? 51.17179 -11.71794 7.16667  1.000 43.42427  ? 240 HOH A O    1 
HETATM 3029 O O    . HOH B 2 .   ? 46.366   -30.108   7.573    1.000 23.07042  ? 241 HOH A O    1 
HETATM 3030 O O    . HOH B 2 .   ? 49.80244 11.22621  22.02340 1.000 54.94534  ? 242 HOH A O    1 
HETATM 3031 O O    . HOH B 2 .   ? 37.91315 -26.11766 16.17452 1.000 38.85866  ? 243 HOH A O    1 
HETATM 3032 O O    . HOH B 2 .   ? 38.95483 -18.92845 0.50167  1.000 46.34362  ? 244 HOH A O    1 
HETATM 3033 O O    . HOH B 2 .   ? 31.81992 -14.54982 26.34870 1.000 24.47996  ? 245 HOH A O    1 
HETATM 3034 O O    . HOH B 2 .   ? 46.00774 -1.86777  21.82743 1.000 28.79895  ? 246 HOH A O    1 
HETATM 3035 O O    . HOH B 2 .   ? 24.08568 0.15055   7.45783  1.000 44.47870  ? 247 HOH A O    1 
HETATM 3036 O O    . HOH B 2 .   ? 27.77066 1.60993   7.78315  1.000 35.69123  ? 248 HOH A O    1 
HETATM 3037 O O    . HOH B 2 .   ? 20.08205 -7.80788  19.38559 1.000 39.76074  ? 249 HOH A O    1 
HETATM 3038 O O    . HOH B 2 .   ? 38.21364 0.16889   1.01028  1.000 51.39780  ? 250 HOH A O    1 
HETATM 3039 O O    . HOH B 2 .   ? 34.91387 -22.47779 15.19612 1.000 45.84026  ? 251 HOH A O    1 
HETATM 3040 O O    . HOH B 2 .   ? 42.226   12.355    11.354   1.000 27.96702  ? 252 HOH A O    1 
HETATM 3041 O O    . HOH B 2 .   ? 29.66404 -10.13590 18.57277 1.000 25.06597  ? 253 HOH A O    1 
HETATM 3042 O O    . HOH B 2 .   ? 32.10449 10.30716  13.04385 1.000 31.06940  ? 254 HOH A O    1 
HETATM 3043 O O    . HOH B 2 .   ? 46.61142 -2.15695  8.26080  1.000 34.37314  ? 255 HOH A O    1 
HETATM 3044 O O    . HOH B 2 .   ? 42.45810 -24.87651 11.15851 1.000 23.78624  ? 256 HOH A O    1 
HETATM 3045 O O    . HOH B 2 .   ? 31.01877 8.37928   11.30299 1.000 46.56803  ? 257 HOH A O    1 
HETATM 3046 O O    . HOH B 2 .   ? 26.77964 -11.98429 30.86059 1.000 42.15160  ? 258 HOH A O    1 
HETATM 3047 O O    . HOH B 2 .   ? 49.91252 5.60730   10.92918 1.000 50.97021  ? 259 HOH A O    1 
HETATM 3048 O O    . HOH B 2 .   ? 41.49460 -23.34613 22.01328 1.000 36.77951  ? 260 HOH A O    1 
HETATM 3049 O O    . HOH B 2 .   ? 52.08309 -9.16542  23.15704 1.000 43.66368  ? 261 HOH A O    1 
HETATM 3050 O O    . HOH B 2 .   ? 54.69047 -15.31335 15.17101 1.000 41.99891  ? 262 HOH A O    1 
HETATM 3051 O O    . HOH B 2 .   ? 40.87297 -15.66227 0.96628  1.000 55.36657  ? 263 HOH A O    1 
HETATM 3052 O O    . HOH B 2 .   ? 49.73046 -17.31440 3.59967  1.000 54.33550  ? 264 HOH A O    1 
HETATM 3053 O O    . HOH B 2 .   ? 48.84740 5.00950   3.64403  1.000 46.85362  ? 265 HOH A O    1 
HETATM 3054 O O    . HOH B 2 .   ? 23.39150 -6.35497  32.59030 1.000 42.20135  ? 266 HOH A O    1 
HETATM 3055 O O    . HOH B 2 .   ? 22.20940 -9.77133  18.92060 1.000 35.64661  ? 267 HOH A O    1 
HETATM 3056 O O    . HOH B 2 .   ? 38.66699 -20.86494 2.63959  1.000 30.83624  ? 268 HOH A O    1 
HETATM 3057 O O    . HOH B 2 .   ? 51.47834 -11.51278 21.57786 1.000 46.22563  ? 269 HOH A O    1 
HETATM 3058 O O    . HOH B 2 .   ? 48.47310 -2.71846  25.18760 1.000 49.57978  ? 270 HOH A O    1 
HETATM 3059 O O    . HOH B 2 .   ? 19.37649 -9.22338  22.36495 1.000 49.39263  ? 271 HOH A O    1 
HETATM 3060 O O    . HOH B 2 .   ? 39.245   -30.159   9.008    1.000 50.76005  ? 272 HOH A O    1 
HETATM 3061 O O    . HOH B 2 .   ? 48.57114 -20.50509 22.94638 1.000 45.15793  ? 273 HOH A O    1 
HETATM 3062 O O    . HOH B 2 .   ? 21.29896 -9.99725  25.02805 1.000 38.98216  ? 274 HOH A O    1 
HETATM 3063 O O    . HOH B 2 .   ? 40.39852 12.49330  22.41531 1.000 38.72584  ? 275 HOH A O    1 
HETATM 3064 O O    . HOH B 2 .   ? 19.12058 -9.87880  12.78652 1.000 40.11677  ? 276 HOH A O    1 
HETATM 3065 O O    . HOH B 2 .   ? 28.92416 6.00671   12.08161 1.000 24.62434  ? 277 HOH A O    1 
HETATM 3066 O O    . HOH B 2 .   ? 35.97080 -15.41294 26.81094 1.000 58.30363  ? 278 HOH A O    1 
HETATM 3067 O O    . HOH B 2 .   ? 22.75710 -12.63259 20.08715 1.000 38.62484  ? 279 HOH A O    1 
HETATM 3068 O O    . HOH B 2 .   ? 44.75991 -22.83452 22.84445 1.000 31.82105  ? 280 HOH A O    1 
HETATM 3069 O O    . HOH B 2 .   ? 21.74752 -20.23585 11.72019 1.000 53.41063  ? 281 HOH A O    1 
HETATM 3070 O O    . HOH B 2 .   ? 38.20223 12.05809  24.01020 1.000 38.32580  ? 282 HOH A O    1 
HETATM 3071 O O    . HOH B 2 .   ? 28.94191 -8.95049  2.80946  1.000 45.55651  ? 283 HOH A O    1 
HETATM 3072 O O    . HOH B 2 .   ? 41.59360 9.19287   3.59841  1.000 56.17433  ? 284 HOH A O    1 
HETATM 3073 O O    . HOH B 2 .   ? 44.90679 -24.31750 4.05819  1.000 29.10252  ? 285 HOH A O    1 
HETATM 3074 O O    . HOH B 2 .   ? 45.92446 -1.20990  25.06052 1.000 49.79496  ? 286 HOH A O    1 
HETATM 3075 O O    . HOH B 2 .   ? 53.572   -20.969   12.421   1.000 47.69475  ? 287 HOH A O    1 
HETATM 3076 O O    . HOH B 2 .   ? 53.70526 -7.84972  17.53514 1.000 38.44171  ? 288 HOH A O    1 
HETATM 3077 O O    . HOH B 2 .   ? 35.79810 7.34883   5.39592  1.000 46.44491  ? 289 HOH A O    1 
HETATM 3078 O O    . HOH B 2 .   ? 30.94989 -23.67788 6.25018  1.000 56.94129  ? 290 HOH A O    1 
HETATM 3079 O O    . HOH B 2 .   ? 51.83218 -6.52423  15.59869 1.000 40.68510  ? 291 HOH A O    1 
HETATM 3080 O O    . HOH B 2 .   ? 25.39129 -16.61839 24.59203 1.000 52.77243  ? 292 HOH A O    1 
HETATM 3081 O O    . HOH B 2 .   ? 24.64049 3.16555   11.77929 1.000 55.66791  ? 293 HOH A O    1 
HETATM 3082 O O    . HOH B 2 .   ? 48.33062 8.54006   3.96789  1.000 55.97142  ? 294 HOH A O    1 
HETATM 3083 O O    . HOH B 2 .   ? 27.02814 -19.00280 23.02382 1.000 49.44572  ? 295 HOH A O    1 
HETATM 3084 O O    . HOH B 2 .   ? 38.938   11.611    8.207    1.000 42.24778  ? 296 HOH A O    1 
HETATM 3085 O O    . HOH B 2 .   ? 35.259   -14.028   27.100   1.000 22.21301  ? 297 HOH A O    1 
HETATM 3086 O O    . HOH B 2 .   ? 37.02828 -27.20096 8.71957  1.000 66.61795  ? 298 HOH A O    1 
HETATM 3087 O O    . HOH B 2 .   ? 48.83347 4.62126   13.68371 1.000 60.33085  ? 299 HOH A O    1 
HETATM 3088 O O    . HOH B 2 .   ? 50.78212 9.54809   18.72562 1.000 54.09076  ? 300 HOH A O    1 
HETATM 3089 O O    . HOH B 2 .   ? 21.07904 -10.95621 21.96680 1.000 55.81967  ? 301 HOH A O    1 
HETATM 3090 O O    . HOH B 2 .   ? 51.68252 7.65538   14.77999 1.000 62.00863  ? 302 HOH A O    1 
# 
