data_9CK2
# 
_entry.id   9CK2 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9CK2         pdb_00009ck2 10.2210/pdb9ck2/pdb 
WWPDB D_1000285631 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-05-21 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9CK2 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-08 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        'Full C-terminus bound to same DNA sequence' 
_pdbx_database_related.db_id          8E3K 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              gpoon@gsu.edu 
_pdbx_contact_author.name_first         Gregory 
_pdbx_contact_author.name_last          Poon 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5107-9458 
# 
_audit_author.name               'Poon, G.M.K.' 
_audit_author.pdbx_ordinal       1 
_audit_author.identifier_ORCID   0000-0001-5107-9458 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Human PU.1 minimal ETS Domain (165-258) bound to d(AATAAGCGGAAGTGGG)' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
_citation_author.citation_id        primary 
_citation_author.name               'Poon, G.M.K.' 
_citation_author.ordinal            1 
_citation_author.identifier_ORCID   0000-0001-5107-9458 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     syn 
;DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*GP*AP*AP*GP*TP*GP*GP*G)-3')
;
5036.292  1   ? ? ? ? 
2 polymer     syn 
;DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3')
;
4760.091  1   ? ? ? ? 
3 polymer     man 'Transcription factor PU.1'                                      11067.025 1   ? ? ? ? 
4 non-polymer syn 'SODIUM ION'                                                     22.990    1   ? ? ? ? 
5 water       nat water                                                            18.015    287 ? ? ? ? 
# 
_entity_name_com.entity_id   3 
_entity_name_com.name        '31 kDa-transforming protein' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 polydeoxyribonucleotide no no '(DA)(DA)(DT)(DA)(DA)(DG)(DC)(DG)(DG)(DA)(DA)(DG)(DT)(DG)(DG)(DG)'                                
AATAAGCGGAAGTGGG                                                                                  C ? 
2 polydeoxyribonucleotide no no '(DT)(DC)(DC)(DC)(DA)(DC)(DT)(DT)(DC)(DC)(DG)(DC)(DT)(DT)(DA)(DT)'                                
TCCCACTTCCGCTTAT                                                                                  D ? 
3 'polypeptide(L)'        no no 
;GSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKV
KKKLTYQFSGEVLG
;
;GSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKV
KKKLTYQFSGEVLG
;
F ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 'SODIUM ION' NA  
5 water        HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1  DA  n 
1 2  DA  n 
1 3  DT  n 
1 4  DA  n 
1 5  DA  n 
1 6  DG  n 
1 7  DC  n 
1 8  DG  n 
1 9  DG  n 
1 10 DA  n 
1 11 DA  n 
1 12 DG  n 
1 13 DT  n 
1 14 DG  n 
1 15 DG  n 
1 16 DG  n 
2 1  DT  n 
2 2  DC  n 
2 3  DC  n 
2 4  DC  n 
2 5  DA  n 
2 6  DC  n 
2 7  DT  n 
2 8  DT  n 
2 9  DC  n 
2 10 DC  n 
2 11 DG  n 
2 12 DC  n 
2 13 DT  n 
2 14 DT  n 
2 15 DA  n 
2 16 DT  n 
3 1  GLY n 
3 2  SER n 
3 3  LYS n 
3 4  LYS n 
3 5  LYS n 
3 6  ILE n 
3 7  ARG n 
3 8  LEU n 
3 9  TYR n 
3 10 GLN n 
3 11 PHE n 
3 12 LEU n 
3 13 LEU n 
3 14 ASP n 
3 15 LEU n 
3 16 LEU n 
3 17 ARG n 
3 18 SER n 
3 19 GLY n 
3 20 ASP n 
3 21 MET n 
3 22 LYS n 
3 23 ASP n 
3 24 SER n 
3 25 ILE n 
3 26 TRP n 
3 27 TRP n 
3 28 VAL n 
3 29 ASP n 
3 30 LYS n 
3 31 ASP n 
3 32 LYS n 
3 33 GLY n 
3 34 THR n 
3 35 PHE n 
3 36 GLN n 
3 37 PHE n 
3 38 SER n 
3 39 SER n 
3 40 LYS n 
3 41 HIS n 
3 42 LYS n 
3 43 GLU n 
3 44 ALA n 
3 45 LEU n 
3 46 ALA n 
3 47 HIS n 
3 48 ARG n 
3 49 TRP n 
3 50 GLY n 
3 51 ILE n 
3 52 GLN n 
3 53 LYS n 
3 54 GLY n 
3 55 ASN n 
3 56 ARG n 
3 57 LYS n 
3 58 LYS n 
3 59 MET n 
3 60 THR n 
3 61 TYR n 
3 62 GLN n 
3 63 LYS n 
3 64 MET n 
3 65 ALA n 
3 66 ARG n 
3 67 ALA n 
3 68 LEU n 
3 69 ARG n 
3 70 ASN n 
3 71 TYR n 
3 72 GLY n 
3 73 LYS n 
3 74 THR n 
3 75 GLY n 
3 76 GLU n 
3 77 VAL n 
3 78 LYS n 
3 79 LYS n 
3 80 VAL n 
3 81 LYS n 
3 82 LYS n 
3 83 LYS n 
3 84 LEU n 
3 85 THR n 
3 86 TYR n 
3 87 GLN n 
3 88 PHE n 
3 89 SER n 
3 90 GLY n 
3 91 GLU n 
3 92 VAL n 
3 93 LEU n 
3 94 GLY n 
# 
_entity_src_gen.entity_id                          3 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   94 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 SPI1 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              Star 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_pdbx_entity_src_syn.entity_id 
_pdbx_entity_src_syn.pdbx_src_id 
_pdbx_entity_src_syn.pdbx_alt_source_flag 
_pdbx_entity_src_syn.pdbx_beg_seq_num 
_pdbx_entity_src_syn.pdbx_end_seq_num 
_pdbx_entity_src_syn.organism_scientific 
_pdbx_entity_src_syn.organism_common_name 
_pdbx_entity_src_syn.ncbi_taxonomy_id 
_pdbx_entity_src_syn.details 
1 1 sample 1 16 'synthetic construct' ? 32630 ? 
2 1 sample 1 16 'synthetic construct' ? 32630 ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                              ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                             ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                           ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                      ? 'C4 H7 N O4'      133.103 
DA  'DNA linking'       y "2'-DEOXYADENOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O6 P' 331.222 
DC  'DNA linking'       y "2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE"  ? 'C9 H14 N3 O7 P'  307.197 
DG  'DNA linking'       y "2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE" ? 'C10 H14 N5 O7 P' 347.221 
DT  'DNA linking'       y "THYMIDINE-5'-MONOPHOSPHATE"         ? 'C10 H15 N2 O8 P' 322.208 
GLN 'L-peptide linking' y GLUTAMINE                            ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                      ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                              ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                            ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                                ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                           ? 'C6 H13 N O2'     131.173 
LEU 'L-peptide linking' y LEUCINE                              ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                               ? 'C6 H15 N2 O2 1'  147.195 
MET 'L-peptide linking' y METHIONINE                           ? 'C5 H11 N O2 S'   149.211 
NA  non-polymer         . 'SODIUM ION'                         ? 'Na 1'            22.990  
PHE 'L-peptide linking' y PHENYLALANINE                        ? 'C9 H11 N O2'     165.189 
SER 'L-peptide linking' y SERINE                               ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                            ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                           ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                             ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                               ? 'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1  DA  1  1   1   DA  DA  C . n 
A 1 2  DA  2  2   2   DA  DA  C . n 
A 1 3  DT  3  3   3   DT  DT  C . n 
A 1 4  DA  4  4   4   DA  DA  C . n 
A 1 5  DA  5  5   5   DA  DA  C . n 
A 1 6  DG  6  6   6   DG  DG  C . n 
A 1 7  DC  7  7   7   DC  DC  C . n 
A 1 8  DG  8  8   8   DG  DG  C . n 
A 1 9  DG  9  9   9   DG  DG  C . n 
A 1 10 DA  10 10  10  DA  DA  C . n 
A 1 11 DA  11 11  11  DA  DA  C . n 
A 1 12 DG  12 12  12  DG  DG  C . n 
A 1 13 DT  13 13  13  DT  DT  C . n 
A 1 14 DG  14 14  14  DG  DG  C . n 
A 1 15 DG  15 15  15  DG  DG  C . n 
A 1 16 DG  16 16  16  DG  DG  C . n 
B 2 1  DT  1  17  17  DT  DT  D . n 
B 2 2  DC  2  18  18  DC  DC  D . n 
B 2 3  DC  3  19  19  DC  DC  D . n 
B 2 4  DC  4  20  20  DC  DC  D . n 
B 2 5  DA  5  21  21  DA  DA  D . n 
B 2 6  DC  6  22  22  DC  DC  D . n 
B 2 7  DT  7  23  23  DT  DT  D . n 
B 2 8  DT  8  24  24  DT  DT  D . n 
B 2 9  DC  9  25  25  DC  DC  D . n 
B 2 10 DC  10 26  26  DC  DC  D . n 
B 2 11 DG  11 27  27  DG  DG  D . n 
B 2 12 DC  12 28  28  DC  DC  D . n 
B 2 13 DT  13 29  29  DT  DT  D . n 
B 2 14 DT  14 30  30  DT  DT  D . n 
B 2 15 DA  15 31  31  DA  DA  D . n 
B 2 16 DT  16 32  32  DT  DT  D . n 
C 3 1  GLY 1  165 ?   ?   ?   F . n 
C 3 2  SER 2  166 ?   ?   ?   F . n 
C 3 3  LYS 3  167 ?   ?   ?   F . n 
C 3 4  LYS 4  168 ?   ?   ?   F . n 
C 3 5  LYS 5  169 169 LYS LYS F . n 
C 3 6  ILE 6  170 170 ILE ILE F . n 
C 3 7  ARG 7  171 171 ARG ARG F . n 
C 3 8  LEU 8  172 172 LEU LEU F . n 
C 3 9  TYR 9  173 173 TYR TYR F . n 
C 3 10 GLN 10 174 174 GLN GLN F . n 
C 3 11 PHE 11 175 175 PHE PHE F . n 
C 3 12 LEU 12 176 176 LEU LEU F . n 
C 3 13 LEU 13 177 177 LEU LEU F . n 
C 3 14 ASP 14 178 178 ASP ASP F . n 
C 3 15 LEU 15 179 179 LEU LEU F . n 
C 3 16 LEU 16 180 180 LEU LEU F . n 
C 3 17 ARG 17 181 181 ARG ARG F . n 
C 3 18 SER 18 182 182 SER SER F . n 
C 3 19 GLY 19 183 183 GLY GLY F . n 
C 3 20 ASP 20 184 184 ASP ASP F . n 
C 3 21 MET 21 185 185 MET MET F . n 
C 3 22 LYS 22 186 186 LYS LYS F . n 
C 3 23 ASP 23 187 187 ASP ASP F . n 
C 3 24 SER 24 188 188 SER SER F . n 
C 3 25 ILE 25 189 189 ILE ILE F . n 
C 3 26 TRP 26 190 190 TRP TRP F . n 
C 3 27 TRP 27 191 191 TRP TRP F . n 
C 3 28 VAL 28 192 192 VAL VAL F . n 
C 3 29 ASP 29 193 193 ASP ASP F . n 
C 3 30 LYS 30 194 194 LYS LYS F . n 
C 3 31 ASP 31 195 195 ASP ASP F . n 
C 3 32 LYS 32 196 196 LYS LYS F . n 
C 3 33 GLY 33 197 197 GLY GLY F . n 
C 3 34 THR 34 198 198 THR THR F . n 
C 3 35 PHE 35 199 199 PHE PHE F . n 
C 3 36 GLN 36 200 200 GLN GLN F . n 
C 3 37 PHE 37 201 201 PHE PHE F . n 
C 3 38 SER 38 202 202 SER SER F . n 
C 3 39 SER 39 203 203 SER SER F . n 
C 3 40 LYS 40 204 204 LYS LYS F . n 
C 3 41 HIS 41 205 205 HIS HIS F . n 
C 3 42 LYS 42 206 206 LYS LYS F . n 
C 3 43 GLU 43 207 207 GLU GLU F . n 
C 3 44 ALA 44 208 208 ALA ALA F . n 
C 3 45 LEU 45 209 209 LEU LEU F . n 
C 3 46 ALA 46 210 210 ALA ALA F . n 
C 3 47 HIS 47 211 211 HIS HIS F . n 
C 3 48 ARG 48 212 212 ARG ARG F . n 
C 3 49 TRP 49 213 213 TRP TRP F . n 
C 3 50 GLY 50 214 214 GLY GLY F . n 
C 3 51 ILE 51 215 215 ILE ILE F . n 
C 3 52 GLN 52 216 216 GLN GLN F . n 
C 3 53 LYS 53 217 217 LYS LYS F . n 
C 3 54 GLY 54 218 218 GLY GLY F . n 
C 3 55 ASN 55 219 219 ASN ASN F . n 
C 3 56 ARG 56 220 220 ARG ARG F . n 
C 3 57 LYS 57 221 221 LYS LYS F . n 
C 3 58 LYS 58 222 222 LYS LYS F . n 
C 3 59 MET 59 223 223 MET MET F . n 
C 3 60 THR 60 224 224 THR THR F . n 
C 3 61 TYR 61 225 225 TYR TYR F . n 
C 3 62 GLN 62 226 226 GLN GLN F . n 
C 3 63 LYS 63 227 227 LYS LYS F . n 
C 3 64 MET 64 228 228 MET MET F . n 
C 3 65 ALA 65 229 229 ALA ALA F . n 
C 3 66 ARG 66 230 230 ARG ARG F . n 
C 3 67 ALA 67 231 231 ALA ALA F . n 
C 3 68 LEU 68 232 232 LEU LEU F . n 
C 3 69 ARG 69 233 233 ARG ARG F . n 
C 3 70 ASN 70 234 234 ASN ASN F . n 
C 3 71 TYR 71 235 235 TYR TYR F . n 
C 3 72 GLY 72 236 236 GLY GLY F . n 
C 3 73 LYS 73 237 237 LYS LYS F . n 
C 3 74 THR 74 238 238 THR THR F . n 
C 3 75 GLY 75 239 239 GLY GLY F . n 
C 3 76 GLU 76 240 240 GLU GLU F . n 
C 3 77 VAL 77 241 241 VAL VAL F . n 
C 3 78 LYS 78 242 242 LYS LYS F . n 
C 3 79 LYS 79 243 243 LYS LYS F . n 
C 3 80 VAL 80 244 244 VAL VAL F . n 
C 3 81 LYS 81 245 245 LYS LYS F . n 
C 3 82 LYS 82 246 246 LYS LYS F . n 
C 3 83 LYS 83 247 247 LYS LYS F . n 
C 3 84 LEU 84 248 248 LEU LEU F . n 
C 3 85 THR 85 249 249 THR THR F . n 
C 3 86 TYR 86 250 250 TYR TYR F . n 
C 3 87 GLN 87 251 251 GLN GLN F . n 
C 3 88 PHE 88 252 252 PHE PHE F . n 
C 3 89 SER 89 253 253 SER SER F . n 
C 3 90 GLY 90 254 254 GLY GLY F . n 
C 3 91 GLU 91 255 255 GLU GLU F . n 
C 3 92 VAL 92 256 256 VAL VAL F . n 
C 3 93 LEU 93 257 257 LEU LEU F . n 
C 3 94 GLY 94 258 258 GLY GLY F . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 NA  1   101 1   NA  NA  C . 
E 5 HOH 1   201 37  HOH HOH C . 
E 5 HOH 2   202 269 HOH HOH C . 
E 5 HOH 3   203 139 HOH HOH C . 
E 5 HOH 4   204 103 HOH HOH C . 
E 5 HOH 5   205 86  HOH HOH C . 
E 5 HOH 6   206 200 HOH HOH C . 
E 5 HOH 7   207 45  HOH HOH C . 
E 5 HOH 8   208 275 HOH HOH C . 
E 5 HOH 9   209 4   HOH HOH C . 
E 5 HOH 10  210 125 HOH HOH C . 
E 5 HOH 11  211 144 HOH HOH C . 
E 5 HOH 12  212 42  HOH HOH C . 
E 5 HOH 13  213 248 HOH HOH C . 
E 5 HOH 14  214 278 HOH HOH C . 
E 5 HOH 15  215 159 HOH HOH C . 
E 5 HOH 16  216 18  HOH HOH C . 
E 5 HOH 17  217 171 HOH HOH C . 
E 5 HOH 18  218 21  HOH HOH C . 
E 5 HOH 19  219 64  HOH HOH C . 
E 5 HOH 20  220 102 HOH HOH C . 
E 5 HOH 21  221 94  HOH HOH C . 
E 5 HOH 22  222 20  HOH HOH C . 
E 5 HOH 23  223 112 HOH HOH C . 
E 5 HOH 24  224 27  HOH HOH C . 
E 5 HOH 25  225 70  HOH HOH C . 
E 5 HOH 26  226 65  HOH HOH C . 
E 5 HOH 27  227 47  HOH HOH C . 
E 5 HOH 28  228 157 HOH HOH C . 
E 5 HOH 29  229 239 HOH HOH C . 
E 5 HOH 30  230 90  HOH HOH C . 
E 5 HOH 31  231 68  HOH HOH C . 
E 5 HOH 32  232 238 HOH HOH C . 
E 5 HOH 33  233 82  HOH HOH C . 
E 5 HOH 34  234 140 HOH HOH C . 
E 5 HOH 35  235 281 HOH HOH C . 
E 5 HOH 36  236 83  HOH HOH C . 
E 5 HOH 37  237 226 HOH HOH C . 
E 5 HOH 38  238 155 HOH HOH C . 
E 5 HOH 39  239 71  HOH HOH C . 
E 5 HOH 40  240 190 HOH HOH C . 
E 5 HOH 41  241 96  HOH HOH C . 
E 5 HOH 42  242 104 HOH HOH C . 
E 5 HOH 43  243 216 HOH HOH C . 
E 5 HOH 44  244 108 HOH HOH C . 
E 5 HOH 45  245 131 HOH HOH C . 
E 5 HOH 46  246 110 HOH HOH C . 
E 5 HOH 47  247 280 HOH HOH C . 
E 5 HOH 48  248 119 HOH HOH C . 
E 5 HOH 49  249 124 HOH HOH C . 
E 5 HOH 50  250 181 HOH HOH C . 
E 5 HOH 51  251 175 HOH HOH C . 
E 5 HOH 52  252 234 HOH HOH C . 
E 5 HOH 53  253 249 HOH HOH C . 
E 5 HOH 54  254 95  HOH HOH C . 
E 5 HOH 55  255 206 HOH HOH C . 
E 5 HOH 56  256 122 HOH HOH C . 
E 5 HOH 57  257 205 HOH HOH C . 
E 5 HOH 58  258 118 HOH HOH C . 
E 5 HOH 59  259 230 HOH HOH C . 
E 5 HOH 60  260 135 HOH HOH C . 
E 5 HOH 61  261 218 HOH HOH C . 
E 5 HOH 62  262 243 HOH HOH C . 
E 5 HOH 63  263 203 HOH HOH C . 
E 5 HOH 64  264 193 HOH HOH C . 
E 5 HOH 65  265 101 HOH HOH C . 
E 5 HOH 66  266 163 HOH HOH C . 
E 5 HOH 67  267 255 HOH HOH C . 
F 5 HOH 1   101 114 HOH HOH D . 
F 5 HOH 2   102 1   HOH HOH D . 
F 5 HOH 3   103 220 HOH HOH D . 
F 5 HOH 4   104 38  HOH HOH D . 
F 5 HOH 5   105 198 HOH HOH D . 
F 5 HOH 6   106 154 HOH HOH D . 
F 5 HOH 7   107 184 HOH HOH D . 
F 5 HOH 8   108 57  HOH HOH D . 
F 5 HOH 9   109 67  HOH HOH D . 
F 5 HOH 10  110 6   HOH HOH D . 
F 5 HOH 11  111 107 HOH HOH D . 
F 5 HOH 12  112 113 HOH HOH D . 
F 5 HOH 13  113 7   HOH HOH D . 
F 5 HOH 14  114 17  HOH HOH D . 
F 5 HOH 15  115 14  HOH HOH D . 
F 5 HOH 16  116 78  HOH HOH D . 
F 5 HOH 17  117 183 HOH HOH D . 
F 5 HOH 18  118 5   HOH HOH D . 
F 5 HOH 19  119 173 HOH HOH D . 
F 5 HOH 20  120 160 HOH HOH D . 
F 5 HOH 21  121 279 HOH HOH D . 
F 5 HOH 22  122 15  HOH HOH D . 
F 5 HOH 23  123 217 HOH HOH D . 
F 5 HOH 24  124 88  HOH HOH D . 
F 5 HOH 25  125 66  HOH HOH D . 
F 5 HOH 26  126 268 HOH HOH D . 
F 5 HOH 27  127 153 HOH HOH D . 
F 5 HOH 28  128 123 HOH HOH D . 
F 5 HOH 29  129 22  HOH HOH D . 
F 5 HOH 30  130 58  HOH HOH D . 
F 5 HOH 31  131 142 HOH HOH D . 
F 5 HOH 32  132 277 HOH HOH D . 
F 5 HOH 33  133 129 HOH HOH D . 
F 5 HOH 34  134 143 HOH HOH D . 
F 5 HOH 35  135 128 HOH HOH D . 
F 5 HOH 36  136 77  HOH HOH D . 
F 5 HOH 37  137 54  HOH HOH D . 
F 5 HOH 38  138 3   HOH HOH D . 
F 5 HOH 39  139 30  HOH HOH D . 
F 5 HOH 40  140 133 HOH HOH D . 
F 5 HOH 41  141 252 HOH HOH D . 
F 5 HOH 42  142 50  HOH HOH D . 
F 5 HOH 43  143 106 HOH HOH D . 
F 5 HOH 44  144 178 HOH HOH D . 
F 5 HOH 45  145 44  HOH HOH D . 
F 5 HOH 46  146 146 HOH HOH D . 
F 5 HOH 47  147 191 HOH HOH D . 
F 5 HOH 48  148 34  HOH HOH D . 
F 5 HOH 49  149 2   HOH HOH D . 
F 5 HOH 50  150 89  HOH HOH D . 
F 5 HOH 51  151 229 HOH HOH D . 
F 5 HOH 52  152 262 HOH HOH D . 
F 5 HOH 53  153 40  HOH HOH D . 
F 5 HOH 54  154 235 HOH HOH D . 
F 5 HOH 55  155 286 HOH HOH D . 
F 5 HOH 56  156 211 HOH HOH D . 
F 5 HOH 57  157 237 HOH HOH D . 
F 5 HOH 58  158 61  HOH HOH D . 
F 5 HOH 59  159 60  HOH HOH D . 
F 5 HOH 60  160 99  HOH HOH D . 
F 5 HOH 61  161 73  HOH HOH D . 
F 5 HOH 62  162 222 HOH HOH D . 
F 5 HOH 63  163 251 HOH HOH D . 
F 5 HOH 64  164 245 HOH HOH D . 
F 5 HOH 65  165 199 HOH HOH D . 
F 5 HOH 66  166 137 HOH HOH D . 
F 5 HOH 67  167 46  HOH HOH D . 
F 5 HOH 68  168 227 HOH HOH D . 
F 5 HOH 69  169 271 HOH HOH D . 
F 5 HOH 70  170 247 HOH HOH D . 
F 5 HOH 71  171 231 HOH HOH D . 
F 5 HOH 72  172 149 HOH HOH D . 
F 5 HOH 73  173 116 HOH HOH D . 
F 5 HOH 74  174 151 HOH HOH D . 
F 5 HOH 75  175 272 HOH HOH D . 
F 5 HOH 76  176 264 HOH HOH D . 
G 5 HOH 1   301 254 HOH HOH F . 
G 5 HOH 2   302 19  HOH HOH F . 
G 5 HOH 3   303 164 HOH HOH F . 
G 5 HOH 4   304 80  HOH HOH F . 
G 5 HOH 5   305 241 HOH HOH F . 
G 5 HOH 6   306 98  HOH HOH F . 
G 5 HOH 7   307 24  HOH HOH F . 
G 5 HOH 8   308 258 HOH HOH F . 
G 5 HOH 9   309 285 HOH HOH F . 
G 5 HOH 10  310 97  HOH HOH F . 
G 5 HOH 11  311 52  HOH HOH F . 
G 5 HOH 12  312 93  HOH HOH F . 
G 5 HOH 13  313 134 HOH HOH F . 
G 5 HOH 14  314 48  HOH HOH F . 
G 5 HOH 15  315 31  HOH HOH F . 
G 5 HOH 16  316 28  HOH HOH F . 
G 5 HOH 17  317 147 HOH HOH F . 
G 5 HOH 18  318 43  HOH HOH F . 
G 5 HOH 19  319 16  HOH HOH F . 
G 5 HOH 20  320 186 HOH HOH F . 
G 5 HOH 21  321 210 HOH HOH F . 
G 5 HOH 22  322 10  HOH HOH F . 
G 5 HOH 23  323 13  HOH HOH F . 
G 5 HOH 24  324 126 HOH HOH F . 
G 5 HOH 25  325 36  HOH HOH F . 
G 5 HOH 26  326 176 HOH HOH F . 
G 5 HOH 27  327 32  HOH HOH F . 
G 5 HOH 28  328 55  HOH HOH F . 
G 5 HOH 29  329 100 HOH HOH F . 
G 5 HOH 30  330 105 HOH HOH F . 
G 5 HOH 31  331 9   HOH HOH F . 
G 5 HOH 32  332 215 HOH HOH F . 
G 5 HOH 33  333 161 HOH HOH F . 
G 5 HOH 34  334 25  HOH HOH F . 
G 5 HOH 35  335 170 HOH HOH F . 
G 5 HOH 36  336 41  HOH HOH F . 
G 5 HOH 37  337 169 HOH HOH F . 
G 5 HOH 38  338 53  HOH HOH F . 
G 5 HOH 39  339 127 HOH HOH F . 
G 5 HOH 40  340 92  HOH HOH F . 
G 5 HOH 41  341 75  HOH HOH F . 
G 5 HOH 42  342 274 HOH HOH F . 
G 5 HOH 43  343 72  HOH HOH F . 
G 5 HOH 44  344 91  HOH HOH F . 
G 5 HOH 45  345 204 HOH HOH F . 
G 5 HOH 46  346 51  HOH HOH F . 
G 5 HOH 47  347 35  HOH HOH F . 
G 5 HOH 48  348 87  HOH HOH F . 
G 5 HOH 49  349 115 HOH HOH F . 
G 5 HOH 50  350 26  HOH HOH F . 
G 5 HOH 51  351 168 HOH HOH F . 
G 5 HOH 52  352 130 HOH HOH F . 
G 5 HOH 53  353 111 HOH HOH F . 
G 5 HOH 54  354 62  HOH HOH F . 
G 5 HOH 55  355 284 HOH HOH F . 
G 5 HOH 56  356 267 HOH HOH F . 
G 5 HOH 57  357 120 HOH HOH F . 
G 5 HOH 58  358 8   HOH HOH F . 
G 5 HOH 59  359 63  HOH HOH F . 
G 5 HOH 60  360 221 HOH HOH F . 
G 5 HOH 61  361 265 HOH HOH F . 
G 5 HOH 62  362 132 HOH HOH F . 
G 5 HOH 63  363 179 HOH HOH F . 
G 5 HOH 64  364 196 HOH HOH F . 
G 5 HOH 65  365 187 HOH HOH F . 
G 5 HOH 66  366 74  HOH HOH F . 
G 5 HOH 67  367 138 HOH HOH F . 
G 5 HOH 68  368 29  HOH HOH F . 
G 5 HOH 69  369 59  HOH HOH F . 
G 5 HOH 70  370 49  HOH HOH F . 
G 5 HOH 71  371 197 HOH HOH F . 
G 5 HOH 72  372 12  HOH HOH F . 
G 5 HOH 73  373 56  HOH HOH F . 
G 5 HOH 74  374 39  HOH HOH F . 
G 5 HOH 75  375 148 HOH HOH F . 
G 5 HOH 76  376 208 HOH HOH F . 
G 5 HOH 77  377 166 HOH HOH F . 
G 5 HOH 78  378 109 HOH HOH F . 
G 5 HOH 79  379 150 HOH HOH F . 
G 5 HOH 80  380 11  HOH HOH F . 
G 5 HOH 81  381 287 HOH HOH F . 
G 5 HOH 82  382 33  HOH HOH F . 
G 5 HOH 83  383 117 HOH HOH F . 
G 5 HOH 84  384 79  HOH HOH F . 
G 5 HOH 85  385 162 HOH HOH F . 
G 5 HOH 86  386 283 HOH HOH F . 
G 5 HOH 87  387 23  HOH HOH F . 
G 5 HOH 88  388 266 HOH HOH F . 
G 5 HOH 89  389 85  HOH HOH F . 
G 5 HOH 90  390 156 HOH HOH F . 
G 5 HOH 91  391 213 HOH HOH F . 
G 5 HOH 92  392 225 HOH HOH F . 
G 5 HOH 93  393 69  HOH HOH F . 
G 5 HOH 94  394 282 HOH HOH F . 
G 5 HOH 95  395 76  HOH HOH F . 
G 5 HOH 96  396 223 HOH HOH F . 
G 5 HOH 97  397 256 HOH HOH F . 
G 5 HOH 98  398 253 HOH HOH F . 
G 5 HOH 99  399 195 HOH HOH F . 
G 5 HOH 100 400 192 HOH HOH F . 
G 5 HOH 101 401 219 HOH HOH F . 
G 5 HOH 102 402 257 HOH HOH F . 
G 5 HOH 103 403 141 HOH HOH F . 
G 5 HOH 104 404 207 HOH HOH F . 
G 5 HOH 105 405 240 HOH HOH F . 
G 5 HOH 106 406 167 HOH HOH F . 
G 5 HOH 107 407 259 HOH HOH F . 
G 5 HOH 108 408 185 HOH HOH F . 
G 5 HOH 109 409 273 HOH HOH F . 
G 5 HOH 110 410 233 HOH HOH F . 
G 5 HOH 111 411 209 HOH HOH F . 
G 5 HOH 112 412 246 HOH HOH F . 
G 5 HOH 113 413 145 HOH HOH F . 
G 5 HOH 114 414 232 HOH HOH F . 
G 5 HOH 115 415 214 HOH HOH F . 
G 5 HOH 116 416 81  HOH HOH F . 
G 5 HOH 117 417 189 HOH HOH F . 
G 5 HOH 118 418 202 HOH HOH F . 
G 5 HOH 119 419 172 HOH HOH F . 
G 5 HOH 120 420 242 HOH HOH F . 
G 5 HOH 121 421 158 HOH HOH F . 
G 5 HOH 122 422 228 HOH HOH F . 
G 5 HOH 123 423 152 HOH HOH F . 
G 5 HOH 124 424 182 HOH HOH F . 
G 5 HOH 125 425 84  HOH HOH F . 
G 5 HOH 126 426 165 HOH HOH F . 
G 5 HOH 127 427 263 HOH HOH F . 
G 5 HOH 128 428 136 HOH HOH F . 
G 5 HOH 129 429 177 HOH HOH F . 
G 5 HOH 130 430 261 HOH HOH F . 
G 5 HOH 131 431 180 HOH HOH F . 
G 5 HOH 132 432 260 HOH HOH F . 
G 5 HOH 133 433 244 HOH HOH F . 
G 5 HOH 134 434 224 HOH HOH F . 
G 5 HOH 135 435 194 HOH HOH F . 
G 5 HOH 136 436 270 HOH HOH F . 
G 5 HOH 137 437 250 HOH HOH F . 
G 5 HOH 138 438 121 HOH HOH F . 
G 5 HOH 139 439 188 HOH HOH F . 
G 5 HOH 140 440 201 HOH HOH F . 
G 5 HOH 141 441 174 HOH HOH F . 
G 5 HOH 142 442 212 HOH HOH F . 
G 5 HOH 143 443 236 HOH HOH F . 
G 5 HOH 144 444 276 HOH HOH F . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 D DT  32  ? "C5'" ? B DT  16 "C5'" 
2  1 Y 1 D DT  32  ? "C4'" ? B DT  16 "C4'" 
3  1 Y 1 D DT  32  ? "O4'" ? B DT  16 "O4'" 
4  1 Y 1 D DT  32  ? "C3'" ? B DT  16 "C3'" 
5  1 Y 1 D DT  32  ? "O3'" ? B DT  16 "O3'" 
6  1 Y 1 D DT  32  ? "C2'" ? B DT  16 "C2'" 
7  1 Y 1 D DT  32  ? "C1'" ? B DT  16 "C1'" 
8  1 Y 1 D DT  32  ? N1    ? B DT  16 N1    
9  1 Y 1 D DT  32  ? C2    ? B DT  16 C2    
10 1 Y 1 D DT  32  ? O2    ? B DT  16 O2    
11 1 Y 1 D DT  32  ? N3    ? B DT  16 N3    
12 1 Y 1 D DT  32  ? C4    ? B DT  16 C4    
13 1 Y 1 D DT  32  ? O4    ? B DT  16 O4    
14 1 Y 1 D DT  32  ? C5    ? B DT  16 C5    
15 1 Y 1 D DT  32  ? C7    ? B DT  16 C7    
16 1 Y 1 D DT  32  ? C6    ? B DT  16 C6    
17 1 Y 1 F LYS 169 ? CG    ? C LYS 5  CG    
18 1 Y 1 F LYS 169 ? CD    ? C LYS 5  CD    
19 1 Y 1 F LYS 169 ? CE    ? C LYS 5  CE    
20 1 Y 1 F LYS 169 ? NZ    ? C LYS 5  NZ    
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   116.593 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9CK2 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     42.871 
_cell.length_a_esd                 ? 
_cell.length_b                     60.569 
_cell.length_b_esd                 ? 
_cell.length_c                     44.292 
_cell.length_c_esd                 ? 
_cell.volume                       102843.847 
_cell.volume_esd                   ? 
_cell.Z_PDB                        2 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9CK2 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                4 
_symmetry.space_group_name_Hall            'P 2yb' 
_symmetry.space_group_name_H-M             'P 1 21 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9CK2 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.31 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          46.82 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              4.6 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '2% PEG 3350, 100 mM Sodium Acetate, pH 4.6' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-10-13 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.977410 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'ALS BEAMLINE 5.0.1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.977410 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   5.0.1 
_diffrn_source.pdbx_synchrotron_site       ALS 
# 
_reflns.B_iso_Wilson_estimate                          16.84 
_reflns.entry_id                                       9CK2 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.71 
_reflns.d_resolution_low                               33.15 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     21885 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                1.9 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.2 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                .036 
_reflns.pdbx_Rpim_I_all                                .025 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   .999 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              .025 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.71 
_reflns_shell.d_res_low                                     1.77 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3.5 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2191 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               1.9 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               .223 
_reflns_shell.pdbx_Rpim_I_all                               .158 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  .964 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.9 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  .158 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               21.13 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9CK2 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.71 
_refine.ls_d_res_low                             33.15 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     21856 
_refine.ls_number_reflns_R_free                  1965 
_refine.ls_number_reflns_R_work                  19891 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.42 
_refine.ls_percent_reflns_R_free                 8.99 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1533 
_refine.ls_R_factor_R_free                       0.1839 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1503 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.39 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 17.5874 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1603 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.71 
_refine_hist.d_res_low                        33.15 
_refine_hist.number_atoms_solvent             287 
_refine_hist.number_atoms_total               1668 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        746 
_refine_hist.pdbx_number_atoms_nucleic_acid   634 
_refine_hist.pdbx_number_atoms_ligand         1 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0098  ? 1487 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.2439  ? 2128 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0602  ? 227  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0124  ? 158  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 24.4372 ? 609  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.71 1.75  . . 143 1390 99.48  . . . . 0.1906 . . . . . . . . . . . 0.2392 
'X-RAY DIFFRACTION' 1.75 1.80  . . 143 1415 99.74  . . . . 0.1835 . . . . . . . . . . . 0.1988 
'X-RAY DIFFRACTION' 1.80 1.85  . . 145 1436 99.81  . . . . 0.1678 . . . . . . . . . . . 0.2154 
'X-RAY DIFFRACTION' 1.85 1.91  . . 141 1401 99.94  . . . . 0.1659 . . . . . . . . . . . 0.1846 
'X-RAY DIFFRACTION' 1.91 1.98  . . 133 1419 99.55  . . . . 0.1651 . . . . . . . . . . . 0.1870 
'X-RAY DIFFRACTION' 1.98 2.06  . . 144 1423 100.00 . . . . 0.1599 . . . . . . . . . . . 0.2201 
'X-RAY DIFFRACTION' 2.06 2.15  . . 136 1431 99.75  . . . . 0.1601 . . . . . . . . . . . 0.2030 
'X-RAY DIFFRACTION' 2.15 2.27  . . 137 1428 99.68  . . . . 0.1619 . . . . . . . . . . . 0.1905 
'X-RAY DIFFRACTION' 2.27 2.41  . . 146 1415 99.68  . . . . 0.1518 . . . . . . . . . . . 0.1772 
'X-RAY DIFFRACTION' 2.41 2.60  . . 140 1416 99.74  . . . . 0.1519 . . . . . . . . . . . 0.1896 
'X-RAY DIFFRACTION' 2.60 2.86  . . 137 1447 99.69  . . . . 0.1587 . . . . . . . . . . . 0.1922 
'X-RAY DIFFRACTION' 2.86 3.27  . . 143 1403 98.60  . . . . 0.1481 . . . . . . . . . . . 0.1790 
'X-RAY DIFFRACTION' 3.27 4.12  . . 140 1410 98.10  . . . . 0.1328 . . . . . . . . . . . 0.1625 
'X-RAY DIFFRACTION' 4.12 33.15 . . 137 1457 98.33  . . . . 0.1322 . . . . . . . . . . . 0.1664 
# 
_struct.entry_id                     9CK2 
_struct.title                        'Human PU.1 minimal ETS Domain (165-258) bound to d(AATAAGCGGAAGTGGG)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9CK2 
_struct_keywords.text            'ETS family transcription factor, DNA BINDING PROTEIN' 
_struct_keywords.pdbx_keywords   'DNA BINDING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 5 ? 
G N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 PDB 9CK2       9CK2   ? 1 ?                                                                                                 1   
2 PDB 9CK2       9CK2   ? 2 ?                                                                                                 1   
3 UNP SPI1_HUMAN P17947 ? 3 
;GSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKV
KKKLTYQFSGEVLG
;
165 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9CK2 C 1 ? 16 ? 9CK2   1   ? 16  ? 1   16  
2 2 9CK2 D 1 ? 16 ? 9CK2   17  ? 32  ? 17  32  
3 3 9CK2 F 1 ? 94 ? P17947 165 ? 258 ? 165 258 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3440 ? 
1 MORE         -33  ? 
1 'SSA (A^2)'  9860 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ARG C 7  ? GLY C 19 ? ARG F 171 GLY F 183 1 ? 13 
HELX_P HELX_P2 AA2 HIS C 41 ? GLY C 54 ? HIS F 205 GLY F 218 1 ? 14 
HELX_P HELX_P3 AA3 THR C 60 ? ASN C 70 ? THR F 224 ASN F 234 1 ? 11 
HELX_P HELX_P4 AA4 ASN C 70 ? GLY C 75 ? ASN F 234 GLY F 239 1 ? 6  
HELX_P HELX_P5 AA5 SER C 89 ? GLY C 94 ? SER F 253 GLY F 258 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A DA 5  OP2   ? ? ? 1_555 D NA  .  NA ? ? C DA 5   C NA  101 1_555 ? ? ? ? ? ? ?            2.097 ? ? 
metalc2  metalc ? ? A DA 5  "O5'" ? ? ? 1_555 D NA  .  NA ? ? C DA 5   C NA  101 1_555 ? ? ? ? ? ? ?            2.996 ? ? 
metalc3  metalc ? ? D NA .  NA    ? ? ? 1_555 E HOH .  O  ? ? C NA 101 C HOH 238 1_555 ? ? ? ? ? ? ?            2.628 ? ? 
metalc4  metalc ? ? D NA .  NA    ? ? ? 1_555 G HOH .  O  ? ? C NA 101 F HOH 360 1_555 ? ? ? ? ? ? ?            2.930 ? ? 
metalc5  metalc ? ? D NA .  NA    ? ? ? 1_555 G HOH .  O  ? ? C NA 101 F HOH 419 1_555 ? ? ? ? ? ? ?            3.021 ? ? 
hydrog1  hydrog ? ? A DT 3  N3    ? ? ? 1_555 B DA  15 N1 ? ? C DT 3   D DA  31  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog2  hydrog ? ? A DT 3  O4    ? ? ? 1_555 B DA  15 N6 ? ? C DT 3   D DA  31  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog3  hydrog ? ? A DA 4  N1    ? ? ? 1_555 B DT  14 N3 ? ? C DA 4   D DT  30  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog4  hydrog ? ? A DA 4  N6    ? ? ? 1_555 B DT  14 O4 ? ? C DA 4   D DT  30  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog5  hydrog ? ? A DA 5  N1    ? ? ? 1_555 B DT  13 N3 ? ? C DA 5   D DT  29  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog6  hydrog ? ? A DA 5  N6    ? ? ? 1_555 B DT  13 O4 ? ? C DA 5   D DT  29  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog7  hydrog ? ? A DG 6  N1    ? ? ? 1_555 B DC  12 N3 ? ? C DG 6   D DC  28  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog8  hydrog ? ? A DG 6  N2    ? ? ? 1_555 B DC  12 O2 ? ? C DG 6   D DC  28  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog9  hydrog ? ? A DG 6  O6    ? ? ? 1_555 B DC  12 N4 ? ? C DG 6   D DC  28  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog10 hydrog ? ? A DC 7  N3    ? ? ? 1_555 B DG  11 N1 ? ? C DC 7   D DG  27  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog11 hydrog ? ? A DC 7  N4    ? ? ? 1_555 B DG  11 O6 ? ? C DC 7   D DG  27  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog12 hydrog ? ? A DC 7  O2    ? ? ? 1_555 B DG  11 N2 ? ? C DC 7   D DG  27  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog13 hydrog ? ? A DG 8  N1    ? ? ? 1_555 B DC  10 N3 ? ? C DG 8   D DC  26  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog14 hydrog ? ? A DG 8  N2    ? ? ? 1_555 B DC  10 O2 ? ? C DG 8   D DC  26  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog15 hydrog ? ? A DG 8  O6    ? ? ? 1_555 B DC  10 N4 ? ? C DG 8   D DC  26  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog16 hydrog ? ? A DG 9  N1    ? ? ? 1_555 B DC  9  N3 ? ? C DG 9   D DC  25  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog17 hydrog ? ? A DG 9  N2    ? ? ? 1_555 B DC  9  O2 ? ? C DG 9   D DC  25  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog18 hydrog ? ? A DG 9  O6    ? ? ? 1_555 B DC  9  N4 ? ? C DG 9   D DC  25  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog19 hydrog ? ? A DA 10 N1    ? ? ? 1_555 B DT  8  N3 ? ? C DA 10  D DT  24  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog20 hydrog ? ? A DA 10 N6    ? ? ? 1_555 B DT  8  O4 ? ? C DA 10  D DT  24  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog21 hydrog ? ? A DA 11 N1    ? ? ? 1_555 B DT  7  N3 ? ? C DA 11  D DT  23  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog22 hydrog ? ? A DA 11 N6    ? ? ? 1_555 B DT  7  O4 ? ? C DA 11  D DT  23  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog23 hydrog ? ? A DG 12 N1    ? ? ? 1_555 B DC  6  N3 ? ? C DG 12  D DC  22  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog24 hydrog ? ? A DG 12 N2    ? ? ? 1_555 B DC  6  O2 ? ? C DG 12  D DC  22  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog25 hydrog ? ? A DG 12 O6    ? ? ? 1_555 B DC  6  N4 ? ? C DG 12  D DC  22  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog26 hydrog ? ? A DT 13 N3    ? ? ? 1_555 B DA  5  N1 ? ? C DT 13  D DA  21  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog27 hydrog ? ? A DT 13 O4    ? ? ? 1_555 B DA  5  N6 ? ? C DT 13  D DA  21  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog28 hydrog ? ? A DG 14 O6    ? ? ? 1_555 B DC  4  N4 ? ? C DG 14  D DC  20  1_555 ? ? ? ? ? ? 'DG-DC PAIR' ?     ? ? 
hydrog29 hydrog ? ? A DG 15 N1    ? ? ? 1_555 B DC  3  N3 ? ? C DG 15  D DC  19  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog30 hydrog ? ? A DG 15 N2    ? ? ? 1_555 B DC  3  O2 ? ? C DG 15  D DC  19  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog31 hydrog ? ? A DG 15 O6    ? ? ? 1_555 B DC  3  N4 ? ? C DG 15  D DC  19  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog32 hydrog ? ? A DG 16 N1    ? ? ? 1_555 B DC  2  N3 ? ? C DG 16  D DC  18  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog33 hydrog ? ? A DG 16 N2    ? ? ? 1_555 B DC  2  O2 ? ? C DG 16  D DC  18  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
hydrog34 hydrog ? ? A DG 16 O6    ? ? ? 1_555 B DC  2  N4 ? ? C DG 16  D DC  18  1_555 ? ? ? ? ? ? WATSON-CRICK ?     ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
metalc ? ? 
hydrog ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OP2   ? A DA  5 ? C DA  5   ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 "O5'" ? A DA  5 ? C DA  5   ? 1_555 54.6  ? 
2  OP2   ? A DA  5 ? C DA  5   ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? E HOH . ? C HOH 238 ? 1_555 75.4  ? 
3  "O5'" ? A DA  5 ? C DA  5   ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? E HOH . ? C HOH 238 ? 1_555 126.9 ? 
4  OP2   ? A DA  5 ? C DA  5   ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? G HOH . ? F HOH 360 ? 1_555 157.0 ? 
5  "O5'" ? A DA  5 ? C DA  5   ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? G HOH . ? F HOH 360 ? 1_555 114.5 ? 
6  O     ? E HOH . ? C HOH 238 ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? G HOH . ? F HOH 360 ? 1_555 118.5 ? 
7  OP2   ? A DA  5 ? C DA  5   ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? G HOH . ? F HOH 419 ? 1_555 118.6 ? 
8  "O5'" ? A DA  5 ? C DA  5   ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? G HOH . ? F HOH 419 ? 1_555 164.3 ? 
9  O     ? E HOH . ? C HOH 238 ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? G HOH . ? F HOH 419 ? 1_555 55.2  ? 
10 O     ? G HOH . ? F HOH 360 ? 1_555 NA ? D NA . ? C NA 101 ? 1_555 O     ? G HOH . ? F HOH 419 ? 1_555 65.8  ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   4 
_struct_sheet.details          ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ILE C 25 ? ASP C 29 ? ILE F 189 ASP F 193 
AA1 2 THR C 34 ? PHE C 37 ? THR F 198 PHE F 201 
AA1 3 THR C 85 ? PHE C 88 ? THR F 249 PHE F 252 
AA1 4 VAL C 77 ? LYS C 79 ? VAL F 241 LYS F 243 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N VAL C 28 ? N VAL F 192 O THR C 34 ? O THR F 198 
AA1 2 3 N PHE C 35 ? N PHE F 199 O TYR C 86 ? O TYR F 250 
AA1 3 4 O GLN C 87 ? O GLN F 251 N LYS C 78 ? N LYS F 242 
# 
_pdbx_entry_details.entry_id                   9CK2 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O D HOH 135 ? ? O F HOH 407 ? ? 2.00 
2 1 O D HOH 156 ? ? O D HOH 157 ? ? 2.00 
3 1 O D HOH 165 ? ? O D HOH 171 ? ? 2.05 
4 1 O F HOH 410 ? ? O F HOH 420 ? ? 2.09 
5 1 O F HOH 313 ? ? O F HOH 343 ? ? 2.10 
6 1 O D HOH 159 ? ? O F HOH 387 ? ? 2.18 
7 1 O C HOH 244 ? ? O D HOH 163 ? ? 2.18 
8 1 O D HOH 132 ? ? O D HOH 164 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    D 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     141 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    F 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     356 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   1_455 
_pdbx_validate_symm_contact.dist              2.03 
# 
loop_
_pdbx_validate_rmsd_bond.id 
_pdbx_validate_rmsd_bond.PDB_model_num 
_pdbx_validate_rmsd_bond.auth_atom_id_1 
_pdbx_validate_rmsd_bond.auth_asym_id_1 
_pdbx_validate_rmsd_bond.auth_comp_id_1 
_pdbx_validate_rmsd_bond.auth_seq_id_1 
_pdbx_validate_rmsd_bond.PDB_ins_code_1 
_pdbx_validate_rmsd_bond.label_alt_id_1 
_pdbx_validate_rmsd_bond.auth_atom_id_2 
_pdbx_validate_rmsd_bond.auth_asym_id_2 
_pdbx_validate_rmsd_bond.auth_comp_id_2 
_pdbx_validate_rmsd_bond.auth_seq_id_2 
_pdbx_validate_rmsd_bond.PDB_ins_code_2 
_pdbx_validate_rmsd_bond.label_alt_id_2 
_pdbx_validate_rmsd_bond.bond_value 
_pdbx_validate_rmsd_bond.bond_target_value 
_pdbx_validate_rmsd_bond.bond_deviation 
_pdbx_validate_rmsd_bond.bond_standard_deviation 
_pdbx_validate_rmsd_bond.linker_flag 
1 1 "O3'" C DG 8  ? ? "C3'" C DG 8  ? ? 1.376 1.419 -0.043 0.006 N 
2 1 "O3'" D DC 28 ? ? "C3'" D DC 28 ? ? 1.379 1.419 -0.040 0.006 N 
3 1 "O3'" D DT 29 ? ? "C3'" D DT 29 ? ? 1.382 1.419 -0.037 0.006 N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 "O4'" C DG 8  ? ? "C1'" C DG 8  ? ? N9 C DG 8  ? ? 111.24 108.30 2.94 0.30 N 
2 1 "O4'" D DC 18 ? ? "C1'" D DC 18 ? ? N1 D DC 18 ? ? 110.78 108.30 2.48 0.30 N 
3 1 "O4'" D DA 21 ? ? "C1'" D DA 21 ? ? N9 D DA 21 ? ? 110.77 108.30 2.47 0.30 N 
4 1 "O4'" D DC 22 ? ? "C1'" D DC 22 ? ? N1 D DC 22 ? ? 110.40 108.30 2.10 0.30 N 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z       
2 -x,y+1/2,-z 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 F GLY 165 ? C GLY 1 
2 1 Y 1 F SER 166 ? C SER 2 
3 1 Y 1 F LYS 167 ? C LYS 3 
4 1 Y 1 F LYS 168 ? C LYS 4 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N      N  N N 1   
ALA CA     C  N S 2   
ALA C      C  N N 3   
ALA O      O  N N 4   
ALA CB     C  N N 5   
ALA OXT    O  N N 6   
ALA H      H  N N 7   
ALA H2     H  N N 8   
ALA HA     H  N N 9   
ALA HB1    H  N N 10  
ALA HB2    H  N N 11  
ALA HB3    H  N N 12  
ALA HXT    H  N N 13  
ARG N      N  N N 14  
ARG CA     C  N S 15  
ARG C      C  N N 16  
ARG O      O  N N 17  
ARG CB     C  N N 18  
ARG CG     C  N N 19  
ARG CD     C  N N 20  
ARG NE     N  N N 21  
ARG CZ     C  N N 22  
ARG NH1    N  N N 23  
ARG NH2    N  N N 24  
ARG OXT    O  N N 25  
ARG H      H  N N 26  
ARG H2     H  N N 27  
ARG HA     H  N N 28  
ARG HB2    H  N N 29  
ARG HB3    H  N N 30  
ARG HG2    H  N N 31  
ARG HG3    H  N N 32  
ARG HD2    H  N N 33  
ARG HD3    H  N N 34  
ARG HE     H  N N 35  
ARG HH11   H  N N 36  
ARG HH12   H  N N 37  
ARG HH21   H  N N 38  
ARG HH22   H  N N 39  
ARG HXT    H  N N 40  
ASN N      N  N N 41  
ASN CA     C  N S 42  
ASN C      C  N N 43  
ASN O      O  N N 44  
ASN CB     C  N N 45  
ASN CG     C  N N 46  
ASN OD1    O  N N 47  
ASN ND2    N  N N 48  
ASN OXT    O  N N 49  
ASN H      H  N N 50  
ASN H2     H  N N 51  
ASN HA     H  N N 52  
ASN HB2    H  N N 53  
ASN HB3    H  N N 54  
ASN HD21   H  N N 55  
ASN HD22   H  N N 56  
ASN HXT    H  N N 57  
ASP N      N  N N 58  
ASP CA     C  N S 59  
ASP C      C  N N 60  
ASP O      O  N N 61  
ASP CB     C  N N 62  
ASP CG     C  N N 63  
ASP OD1    O  N N 64  
ASP OD2    O  N N 65  
ASP OXT    O  N N 66  
ASP H      H  N N 67  
ASP H2     H  N N 68  
ASP HA     H  N N 69  
ASP HB2    H  N N 70  
ASP HB3    H  N N 71  
ASP HD2    H  N N 72  
ASP HXT    H  N N 73  
DA  OP3    O  N N 74  
DA  P      P  N N 75  
DA  OP1    O  N N 76  
DA  OP2    O  N N 77  
DA  "O5'"  O  N N 78  
DA  "C5'"  C  N N 79  
DA  "C4'"  C  N R 80  
DA  "O4'"  O  N N 81  
DA  "C3'"  C  N S 82  
DA  "O3'"  O  N N 83  
DA  "C2'"  C  N N 84  
DA  "C1'"  C  N R 85  
DA  N9     N  Y N 86  
DA  C8     C  Y N 87  
DA  N7     N  Y N 88  
DA  C5     C  Y N 89  
DA  C6     C  Y N 90  
DA  N6     N  N N 91  
DA  N1     N  Y N 92  
DA  C2     C  Y N 93  
DA  N3     N  Y N 94  
DA  C4     C  Y N 95  
DA  HOP3   H  N N 96  
DA  HOP2   H  N N 97  
DA  "H5'"  H  N N 98  
DA  "H5''" H  N N 99  
DA  "H4'"  H  N N 100 
DA  "H3'"  H  N N 101 
DA  "HO3'" H  N N 102 
DA  "H2'"  H  N N 103 
DA  "H2''" H  N N 104 
DA  "H1'"  H  N N 105 
DA  H8     H  N N 106 
DA  H61    H  N N 107 
DA  H62    H  N N 108 
DA  H2     H  N N 109 
DC  OP3    O  N N 110 
DC  P      P  N N 111 
DC  OP1    O  N N 112 
DC  OP2    O  N N 113 
DC  "O5'"  O  N N 114 
DC  "C5'"  C  N N 115 
DC  "C4'"  C  N R 116 
DC  "O4'"  O  N N 117 
DC  "C3'"  C  N S 118 
DC  "O3'"  O  N N 119 
DC  "C2'"  C  N N 120 
DC  "C1'"  C  N R 121 
DC  N1     N  N N 122 
DC  C2     C  N N 123 
DC  O2     O  N N 124 
DC  N3     N  N N 125 
DC  C4     C  N N 126 
DC  N4     N  N N 127 
DC  C5     C  N N 128 
DC  C6     C  N N 129 
DC  HOP3   H  N N 130 
DC  HOP2   H  N N 131 
DC  "H5'"  H  N N 132 
DC  "H5''" H  N N 133 
DC  "H4'"  H  N N 134 
DC  "H3'"  H  N N 135 
DC  "HO3'" H  N N 136 
DC  "H2'"  H  N N 137 
DC  "H2''" H  N N 138 
DC  "H1'"  H  N N 139 
DC  H41    H  N N 140 
DC  H42    H  N N 141 
DC  H5     H  N N 142 
DC  H6     H  N N 143 
DG  OP3    O  N N 144 
DG  P      P  N N 145 
DG  OP1    O  N N 146 
DG  OP2    O  N N 147 
DG  "O5'"  O  N N 148 
DG  "C5'"  C  N N 149 
DG  "C4'"  C  N R 150 
DG  "O4'"  O  N N 151 
DG  "C3'"  C  N S 152 
DG  "O3'"  O  N N 153 
DG  "C2'"  C  N N 154 
DG  "C1'"  C  N R 155 
DG  N9     N  Y N 156 
DG  C8     C  Y N 157 
DG  N7     N  Y N 158 
DG  C5     C  Y N 159 
DG  C6     C  N N 160 
DG  O6     O  N N 161 
DG  N1     N  N N 162 
DG  C2     C  N N 163 
DG  N2     N  N N 164 
DG  N3     N  N N 165 
DG  C4     C  Y N 166 
DG  HOP3   H  N N 167 
DG  HOP2   H  N N 168 
DG  "H5'"  H  N N 169 
DG  "H5''" H  N N 170 
DG  "H4'"  H  N N 171 
DG  "H3'"  H  N N 172 
DG  "HO3'" H  N N 173 
DG  "H2'"  H  N N 174 
DG  "H2''" H  N N 175 
DG  "H1'"  H  N N 176 
DG  H8     H  N N 177 
DG  H1     H  N N 178 
DG  H21    H  N N 179 
DG  H22    H  N N 180 
DT  OP3    O  N N 181 
DT  P      P  N N 182 
DT  OP1    O  N N 183 
DT  OP2    O  N N 184 
DT  "O5'"  O  N N 185 
DT  "C5'"  C  N N 186 
DT  "C4'"  C  N R 187 
DT  "O4'"  O  N N 188 
DT  "C3'"  C  N S 189 
DT  "O3'"  O  N N 190 
DT  "C2'"  C  N N 191 
DT  "C1'"  C  N R 192 
DT  N1     N  N N 193 
DT  C2     C  N N 194 
DT  O2     O  N N 195 
DT  N3     N  N N 196 
DT  C4     C  N N 197 
DT  O4     O  N N 198 
DT  C5     C  N N 199 
DT  C7     C  N N 200 
DT  C6     C  N N 201 
DT  HOP3   H  N N 202 
DT  HOP2   H  N N 203 
DT  "H5'"  H  N N 204 
DT  "H5''" H  N N 205 
DT  "H4'"  H  N N 206 
DT  "H3'"  H  N N 207 
DT  "HO3'" H  N N 208 
DT  "H2'"  H  N N 209 
DT  "H2''" H  N N 210 
DT  "H1'"  H  N N 211 
DT  H3     H  N N 212 
DT  H71    H  N N 213 
DT  H72    H  N N 214 
DT  H73    H  N N 215 
DT  H6     H  N N 216 
GLN N      N  N N 217 
GLN CA     C  N S 218 
GLN C      C  N N 219 
GLN O      O  N N 220 
GLN CB     C  N N 221 
GLN CG     C  N N 222 
GLN CD     C  N N 223 
GLN OE1    O  N N 224 
GLN NE2    N  N N 225 
GLN OXT    O  N N 226 
GLN H      H  N N 227 
GLN H2     H  N N 228 
GLN HA     H  N N 229 
GLN HB2    H  N N 230 
GLN HB3    H  N N 231 
GLN HG2    H  N N 232 
GLN HG3    H  N N 233 
GLN HE21   H  N N 234 
GLN HE22   H  N N 235 
GLN HXT    H  N N 236 
GLU N      N  N N 237 
GLU CA     C  N S 238 
GLU C      C  N N 239 
GLU O      O  N N 240 
GLU CB     C  N N 241 
GLU CG     C  N N 242 
GLU CD     C  N N 243 
GLU OE1    O  N N 244 
GLU OE2    O  N N 245 
GLU OXT    O  N N 246 
GLU H      H  N N 247 
GLU H2     H  N N 248 
GLU HA     H  N N 249 
GLU HB2    H  N N 250 
GLU HB3    H  N N 251 
GLU HG2    H  N N 252 
GLU HG3    H  N N 253 
GLU HE2    H  N N 254 
GLU HXT    H  N N 255 
GLY N      N  N N 256 
GLY CA     C  N N 257 
GLY C      C  N N 258 
GLY O      O  N N 259 
GLY OXT    O  N N 260 
GLY H      H  N N 261 
GLY H2     H  N N 262 
GLY HA2    H  N N 263 
GLY HA3    H  N N 264 
GLY HXT    H  N N 265 
HIS N      N  N N 266 
HIS CA     C  N S 267 
HIS C      C  N N 268 
HIS O      O  N N 269 
HIS CB     C  N N 270 
HIS CG     C  Y N 271 
HIS ND1    N  Y N 272 
HIS CD2    C  Y N 273 
HIS CE1    C  Y N 274 
HIS NE2    N  Y N 275 
HIS OXT    O  N N 276 
HIS H      H  N N 277 
HIS H2     H  N N 278 
HIS HA     H  N N 279 
HIS HB2    H  N N 280 
HIS HB3    H  N N 281 
HIS HD1    H  N N 282 
HIS HD2    H  N N 283 
HIS HE1    H  N N 284 
HIS HE2    H  N N 285 
HIS HXT    H  N N 286 
HOH O      O  N N 287 
HOH H1     H  N N 288 
HOH H2     H  N N 289 
ILE N      N  N N 290 
ILE CA     C  N S 291 
ILE C      C  N N 292 
ILE O      O  N N 293 
ILE CB     C  N S 294 
ILE CG1    C  N N 295 
ILE CG2    C  N N 296 
ILE CD1    C  N N 297 
ILE OXT    O  N N 298 
ILE H      H  N N 299 
ILE H2     H  N N 300 
ILE HA     H  N N 301 
ILE HB     H  N N 302 
ILE HG12   H  N N 303 
ILE HG13   H  N N 304 
ILE HG21   H  N N 305 
ILE HG22   H  N N 306 
ILE HG23   H  N N 307 
ILE HD11   H  N N 308 
ILE HD12   H  N N 309 
ILE HD13   H  N N 310 
ILE HXT    H  N N 311 
LEU N      N  N N 312 
LEU CA     C  N S 313 
LEU C      C  N N 314 
LEU O      O  N N 315 
LEU CB     C  N N 316 
LEU CG     C  N N 317 
LEU CD1    C  N N 318 
LEU CD2    C  N N 319 
LEU OXT    O  N N 320 
LEU H      H  N N 321 
LEU H2     H  N N 322 
LEU HA     H  N N 323 
LEU HB2    H  N N 324 
LEU HB3    H  N N 325 
LEU HG     H  N N 326 
LEU HD11   H  N N 327 
LEU HD12   H  N N 328 
LEU HD13   H  N N 329 
LEU HD21   H  N N 330 
LEU HD22   H  N N 331 
LEU HD23   H  N N 332 
LEU HXT    H  N N 333 
LYS N      N  N N 334 
LYS CA     C  N S 335 
LYS C      C  N N 336 
LYS O      O  N N 337 
LYS CB     C  N N 338 
LYS CG     C  N N 339 
LYS CD     C  N N 340 
LYS CE     C  N N 341 
LYS NZ     N  N N 342 
LYS OXT    O  N N 343 
LYS H      H  N N 344 
LYS H2     H  N N 345 
LYS HA     H  N N 346 
LYS HB2    H  N N 347 
LYS HB3    H  N N 348 
LYS HG2    H  N N 349 
LYS HG3    H  N N 350 
LYS HD2    H  N N 351 
LYS HD3    H  N N 352 
LYS HE2    H  N N 353 
LYS HE3    H  N N 354 
LYS HZ1    H  N N 355 
LYS HZ2    H  N N 356 
LYS HZ3    H  N N 357 
LYS HXT    H  N N 358 
MET N      N  N N 359 
MET CA     C  N S 360 
MET C      C  N N 361 
MET O      O  N N 362 
MET CB     C  N N 363 
MET CG     C  N N 364 
MET SD     S  N N 365 
MET CE     C  N N 366 
MET OXT    O  N N 367 
MET H      H  N N 368 
MET H2     H  N N 369 
MET HA     H  N N 370 
MET HB2    H  N N 371 
MET HB3    H  N N 372 
MET HG2    H  N N 373 
MET HG3    H  N N 374 
MET HE1    H  N N 375 
MET HE2    H  N N 376 
MET HE3    H  N N 377 
MET HXT    H  N N 378 
NA  NA     NA N N 379 
PHE N      N  N N 380 
PHE CA     C  N S 381 
PHE C      C  N N 382 
PHE O      O  N N 383 
PHE CB     C  N N 384 
PHE CG     C  Y N 385 
PHE CD1    C  Y N 386 
PHE CD2    C  Y N 387 
PHE CE1    C  Y N 388 
PHE CE2    C  Y N 389 
PHE CZ     C  Y N 390 
PHE OXT    O  N N 391 
PHE H      H  N N 392 
PHE H2     H  N N 393 
PHE HA     H  N N 394 
PHE HB2    H  N N 395 
PHE HB3    H  N N 396 
PHE HD1    H  N N 397 
PHE HD2    H  N N 398 
PHE HE1    H  N N 399 
PHE HE2    H  N N 400 
PHE HZ     H  N N 401 
PHE HXT    H  N N 402 
SER N      N  N N 403 
SER CA     C  N S 404 
SER C      C  N N 405 
SER O      O  N N 406 
SER CB     C  N N 407 
SER OG     O  N N 408 
SER OXT    O  N N 409 
SER H      H  N N 410 
SER H2     H  N N 411 
SER HA     H  N N 412 
SER HB2    H  N N 413 
SER HB3    H  N N 414 
SER HG     H  N N 415 
SER HXT    H  N N 416 
THR N      N  N N 417 
THR CA     C  N S 418 
THR C      C  N N 419 
THR O      O  N N 420 
THR CB     C  N R 421 
THR OG1    O  N N 422 
THR CG2    C  N N 423 
THR OXT    O  N N 424 
THR H      H  N N 425 
THR H2     H  N N 426 
THR HA     H  N N 427 
THR HB     H  N N 428 
THR HG1    H  N N 429 
THR HG21   H  N N 430 
THR HG22   H  N N 431 
THR HG23   H  N N 432 
THR HXT    H  N N 433 
TRP N      N  N N 434 
TRP CA     C  N S 435 
TRP C      C  N N 436 
TRP O      O  N N 437 
TRP CB     C  N N 438 
TRP CG     C  Y N 439 
TRP CD1    C  Y N 440 
TRP CD2    C  Y N 441 
TRP NE1    N  Y N 442 
TRP CE2    C  Y N 443 
TRP CE3    C  Y N 444 
TRP CZ2    C  Y N 445 
TRP CZ3    C  Y N 446 
TRP CH2    C  Y N 447 
TRP OXT    O  N N 448 
TRP H      H  N N 449 
TRP H2     H  N N 450 
TRP HA     H  N N 451 
TRP HB2    H  N N 452 
TRP HB3    H  N N 453 
TRP HD1    H  N N 454 
TRP HE1    H  N N 455 
TRP HE3    H  N N 456 
TRP HZ2    H  N N 457 
TRP HZ3    H  N N 458 
TRP HH2    H  N N 459 
TRP HXT    H  N N 460 
TYR N      N  N N 461 
TYR CA     C  N S 462 
TYR C      C  N N 463 
TYR O      O  N N 464 
TYR CB     C  N N 465 
TYR CG     C  Y N 466 
TYR CD1    C  Y N 467 
TYR CD2    C  Y N 468 
TYR CE1    C  Y N 469 
TYR CE2    C  Y N 470 
TYR CZ     C  Y N 471 
TYR OH     O  N N 472 
TYR OXT    O  N N 473 
TYR H      H  N N 474 
TYR H2     H  N N 475 
TYR HA     H  N N 476 
TYR HB2    H  N N 477 
TYR HB3    H  N N 478 
TYR HD1    H  N N 479 
TYR HD2    H  N N 480 
TYR HE1    H  N N 481 
TYR HE2    H  N N 482 
TYR HH     H  N N 483 
TYR HXT    H  N N 484 
VAL N      N  N N 485 
VAL CA     C  N S 486 
VAL C      C  N N 487 
VAL O      O  N N 488 
VAL CB     C  N N 489 
VAL CG1    C  N N 490 
VAL CG2    C  N N 491 
VAL OXT    O  N N 492 
VAL H      H  N N 493 
VAL H2     H  N N 494 
VAL HA     H  N N 495 
VAL HB     H  N N 496 
VAL HG11   H  N N 497 
VAL HG12   H  N N 498 
VAL HG13   H  N N 499 
VAL HG21   H  N N 500 
VAL HG22   H  N N 501 
VAL HG23   H  N N 502 
VAL HXT    H  N N 503 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA     sing N N 1   
ALA N     H      sing N N 2   
ALA N     H2     sing N N 3   
ALA CA    C      sing N N 4   
ALA CA    CB     sing N N 5   
ALA CA    HA     sing N N 6   
ALA C     O      doub N N 7   
ALA C     OXT    sing N N 8   
ALA CB    HB1    sing N N 9   
ALA CB    HB2    sing N N 10  
ALA CB    HB3    sing N N 11  
ALA OXT   HXT    sing N N 12  
ARG N     CA     sing N N 13  
ARG N     H      sing N N 14  
ARG N     H2     sing N N 15  
ARG CA    C      sing N N 16  
ARG CA    CB     sing N N 17  
ARG CA    HA     sing N N 18  
ARG C     O      doub N N 19  
ARG C     OXT    sing N N 20  
ARG CB    CG     sing N N 21  
ARG CB    HB2    sing N N 22  
ARG CB    HB3    sing N N 23  
ARG CG    CD     sing N N 24  
ARG CG    HG2    sing N N 25  
ARG CG    HG3    sing N N 26  
ARG CD    NE     sing N N 27  
ARG CD    HD2    sing N N 28  
ARG CD    HD3    sing N N 29  
ARG NE    CZ     sing N N 30  
ARG NE    HE     sing N N 31  
ARG CZ    NH1    sing N N 32  
ARG CZ    NH2    doub N N 33  
ARG NH1   HH11   sing N N 34  
ARG NH1   HH12   sing N N 35  
ARG NH2   HH21   sing N N 36  
ARG NH2   HH22   sing N N 37  
ARG OXT   HXT    sing N N 38  
ASN N     CA     sing N N 39  
ASN N     H      sing N N 40  
ASN N     H2     sing N N 41  
ASN CA    C      sing N N 42  
ASN CA    CB     sing N N 43  
ASN CA    HA     sing N N 44  
ASN C     O      doub N N 45  
ASN C     OXT    sing N N 46  
ASN CB    CG     sing N N 47  
ASN CB    HB2    sing N N 48  
ASN CB    HB3    sing N N 49  
ASN CG    OD1    doub N N 50  
ASN CG    ND2    sing N N 51  
ASN ND2   HD21   sing N N 52  
ASN ND2   HD22   sing N N 53  
ASN OXT   HXT    sing N N 54  
ASP N     CA     sing N N 55  
ASP N     H      sing N N 56  
ASP N     H2     sing N N 57  
ASP CA    C      sing N N 58  
ASP CA    CB     sing N N 59  
ASP CA    HA     sing N N 60  
ASP C     O      doub N N 61  
ASP C     OXT    sing N N 62  
ASP CB    CG     sing N N 63  
ASP CB    HB2    sing N N 64  
ASP CB    HB3    sing N N 65  
ASP CG    OD1    doub N N 66  
ASP CG    OD2    sing N N 67  
ASP OD2   HD2    sing N N 68  
ASP OXT   HXT    sing N N 69  
DA  OP3   P      sing N N 70  
DA  OP3   HOP3   sing N N 71  
DA  P     OP1    doub N N 72  
DA  P     OP2    sing N N 73  
DA  P     "O5'"  sing N N 74  
DA  OP2   HOP2   sing N N 75  
DA  "O5'" "C5'"  sing N N 76  
DA  "C5'" "C4'"  sing N N 77  
DA  "C5'" "H5'"  sing N N 78  
DA  "C5'" "H5''" sing N N 79  
DA  "C4'" "O4'"  sing N N 80  
DA  "C4'" "C3'"  sing N N 81  
DA  "C4'" "H4'"  sing N N 82  
DA  "O4'" "C1'"  sing N N 83  
DA  "C3'" "O3'"  sing N N 84  
DA  "C3'" "C2'"  sing N N 85  
DA  "C3'" "H3'"  sing N N 86  
DA  "O3'" "HO3'" sing N N 87  
DA  "C2'" "C1'"  sing N N 88  
DA  "C2'" "H2'"  sing N N 89  
DA  "C2'" "H2''" sing N N 90  
DA  "C1'" N9     sing N N 91  
DA  "C1'" "H1'"  sing N N 92  
DA  N9    C8     sing Y N 93  
DA  N9    C4     sing Y N 94  
DA  C8    N7     doub Y N 95  
DA  C8    H8     sing N N 96  
DA  N7    C5     sing Y N 97  
DA  C5    C6     sing Y N 98  
DA  C5    C4     doub Y N 99  
DA  C6    N6     sing N N 100 
DA  C6    N1     doub Y N 101 
DA  N6    H61    sing N N 102 
DA  N6    H62    sing N N 103 
DA  N1    C2     sing Y N 104 
DA  C2    N3     doub Y N 105 
DA  C2    H2     sing N N 106 
DA  N3    C4     sing Y N 107 
DC  OP3   P      sing N N 108 
DC  OP3   HOP3   sing N N 109 
DC  P     OP1    doub N N 110 
DC  P     OP2    sing N N 111 
DC  P     "O5'"  sing N N 112 
DC  OP2   HOP2   sing N N 113 
DC  "O5'" "C5'"  sing N N 114 
DC  "C5'" "C4'"  sing N N 115 
DC  "C5'" "H5'"  sing N N 116 
DC  "C5'" "H5''" sing N N 117 
DC  "C4'" "O4'"  sing N N 118 
DC  "C4'" "C3'"  sing N N 119 
DC  "C4'" "H4'"  sing N N 120 
DC  "O4'" "C1'"  sing N N 121 
DC  "C3'" "O3'"  sing N N 122 
DC  "C3'" "C2'"  sing N N 123 
DC  "C3'" "H3'"  sing N N 124 
DC  "O3'" "HO3'" sing N N 125 
DC  "C2'" "C1'"  sing N N 126 
DC  "C2'" "H2'"  sing N N 127 
DC  "C2'" "H2''" sing N N 128 
DC  "C1'" N1     sing N N 129 
DC  "C1'" "H1'"  sing N N 130 
DC  N1    C2     sing N N 131 
DC  N1    C6     sing N N 132 
DC  C2    O2     doub N N 133 
DC  C2    N3     sing N N 134 
DC  N3    C4     doub N N 135 
DC  C4    N4     sing N N 136 
DC  C4    C5     sing N N 137 
DC  N4    H41    sing N N 138 
DC  N4    H42    sing N N 139 
DC  C5    C6     doub N N 140 
DC  C5    H5     sing N N 141 
DC  C6    H6     sing N N 142 
DG  OP3   P      sing N N 143 
DG  OP3   HOP3   sing N N 144 
DG  P     OP1    doub N N 145 
DG  P     OP2    sing N N 146 
DG  P     "O5'"  sing N N 147 
DG  OP2   HOP2   sing N N 148 
DG  "O5'" "C5'"  sing N N 149 
DG  "C5'" "C4'"  sing N N 150 
DG  "C5'" "H5'"  sing N N 151 
DG  "C5'" "H5''" sing N N 152 
DG  "C4'" "O4'"  sing N N 153 
DG  "C4'" "C3'"  sing N N 154 
DG  "C4'" "H4'"  sing N N 155 
DG  "O4'" "C1'"  sing N N 156 
DG  "C3'" "O3'"  sing N N 157 
DG  "C3'" "C2'"  sing N N 158 
DG  "C3'" "H3'"  sing N N 159 
DG  "O3'" "HO3'" sing N N 160 
DG  "C2'" "C1'"  sing N N 161 
DG  "C2'" "H2'"  sing N N 162 
DG  "C2'" "H2''" sing N N 163 
DG  "C1'" N9     sing N N 164 
DG  "C1'" "H1'"  sing N N 165 
DG  N9    C8     sing Y N 166 
DG  N9    C4     sing Y N 167 
DG  C8    N7     doub Y N 168 
DG  C8    H8     sing N N 169 
DG  N7    C5     sing Y N 170 
DG  C5    C6     sing N N 171 
DG  C5    C4     doub Y N 172 
DG  C6    O6     doub N N 173 
DG  C6    N1     sing N N 174 
DG  N1    C2     sing N N 175 
DG  N1    H1     sing N N 176 
DG  C2    N2     sing N N 177 
DG  C2    N3     doub N N 178 
DG  N2    H21    sing N N 179 
DG  N2    H22    sing N N 180 
DG  N3    C4     sing N N 181 
DT  OP3   P      sing N N 182 
DT  OP3   HOP3   sing N N 183 
DT  P     OP1    doub N N 184 
DT  P     OP2    sing N N 185 
DT  P     "O5'"  sing N N 186 
DT  OP2   HOP2   sing N N 187 
DT  "O5'" "C5'"  sing N N 188 
DT  "C5'" "C4'"  sing N N 189 
DT  "C5'" "H5'"  sing N N 190 
DT  "C5'" "H5''" sing N N 191 
DT  "C4'" "O4'"  sing N N 192 
DT  "C4'" "C3'"  sing N N 193 
DT  "C4'" "H4'"  sing N N 194 
DT  "O4'" "C1'"  sing N N 195 
DT  "C3'" "O3'"  sing N N 196 
DT  "C3'" "C2'"  sing N N 197 
DT  "C3'" "H3'"  sing N N 198 
DT  "O3'" "HO3'" sing N N 199 
DT  "C2'" "C1'"  sing N N 200 
DT  "C2'" "H2'"  sing N N 201 
DT  "C2'" "H2''" sing N N 202 
DT  "C1'" N1     sing N N 203 
DT  "C1'" "H1'"  sing N N 204 
DT  N1    C2     sing N N 205 
DT  N1    C6     sing N N 206 
DT  C2    O2     doub N N 207 
DT  C2    N3     sing N N 208 
DT  N3    C4     sing N N 209 
DT  N3    H3     sing N N 210 
DT  C4    O4     doub N N 211 
DT  C4    C5     sing N N 212 
DT  C5    C7     sing N N 213 
DT  C5    C6     doub N N 214 
DT  C7    H71    sing N N 215 
DT  C7    H72    sing N N 216 
DT  C7    H73    sing N N 217 
DT  C6    H6     sing N N 218 
GLN N     CA     sing N N 219 
GLN N     H      sing N N 220 
GLN N     H2     sing N N 221 
GLN CA    C      sing N N 222 
GLN CA    CB     sing N N 223 
GLN CA    HA     sing N N 224 
GLN C     O      doub N N 225 
GLN C     OXT    sing N N 226 
GLN CB    CG     sing N N 227 
GLN CB    HB2    sing N N 228 
GLN CB    HB3    sing N N 229 
GLN CG    CD     sing N N 230 
GLN CG    HG2    sing N N 231 
GLN CG    HG3    sing N N 232 
GLN CD    OE1    doub N N 233 
GLN CD    NE2    sing N N 234 
GLN NE2   HE21   sing N N 235 
GLN NE2   HE22   sing N N 236 
GLN OXT   HXT    sing N N 237 
GLU N     CA     sing N N 238 
GLU N     H      sing N N 239 
GLU N     H2     sing N N 240 
GLU CA    C      sing N N 241 
GLU CA    CB     sing N N 242 
GLU CA    HA     sing N N 243 
GLU C     O      doub N N 244 
GLU C     OXT    sing N N 245 
GLU CB    CG     sing N N 246 
GLU CB    HB2    sing N N 247 
GLU CB    HB3    sing N N 248 
GLU CG    CD     sing N N 249 
GLU CG    HG2    sing N N 250 
GLU CG    HG3    sing N N 251 
GLU CD    OE1    doub N N 252 
GLU CD    OE2    sing N N 253 
GLU OE2   HE2    sing N N 254 
GLU OXT   HXT    sing N N 255 
GLY N     CA     sing N N 256 
GLY N     H      sing N N 257 
GLY N     H2     sing N N 258 
GLY CA    C      sing N N 259 
GLY CA    HA2    sing N N 260 
GLY CA    HA3    sing N N 261 
GLY C     O      doub N N 262 
GLY C     OXT    sing N N 263 
GLY OXT   HXT    sing N N 264 
HIS N     CA     sing N N 265 
HIS N     H      sing N N 266 
HIS N     H2     sing N N 267 
HIS CA    C      sing N N 268 
HIS CA    CB     sing N N 269 
HIS CA    HA     sing N N 270 
HIS C     O      doub N N 271 
HIS C     OXT    sing N N 272 
HIS CB    CG     sing N N 273 
HIS CB    HB2    sing N N 274 
HIS CB    HB3    sing N N 275 
HIS CG    ND1    sing Y N 276 
HIS CG    CD2    doub Y N 277 
HIS ND1   CE1    doub Y N 278 
HIS ND1   HD1    sing N N 279 
HIS CD2   NE2    sing Y N 280 
HIS CD2   HD2    sing N N 281 
HIS CE1   NE2    sing Y N 282 
HIS CE1   HE1    sing N N 283 
HIS NE2   HE2    sing N N 284 
HIS OXT   HXT    sing N N 285 
HOH O     H1     sing N N 286 
HOH O     H2     sing N N 287 
ILE N     CA     sing N N 288 
ILE N     H      sing N N 289 
ILE N     H2     sing N N 290 
ILE CA    C      sing N N 291 
ILE CA    CB     sing N N 292 
ILE CA    HA     sing N N 293 
ILE C     O      doub N N 294 
ILE C     OXT    sing N N 295 
ILE CB    CG1    sing N N 296 
ILE CB    CG2    sing N N 297 
ILE CB    HB     sing N N 298 
ILE CG1   CD1    sing N N 299 
ILE CG1   HG12   sing N N 300 
ILE CG1   HG13   sing N N 301 
ILE CG2   HG21   sing N N 302 
ILE CG2   HG22   sing N N 303 
ILE CG2   HG23   sing N N 304 
ILE CD1   HD11   sing N N 305 
ILE CD1   HD12   sing N N 306 
ILE CD1   HD13   sing N N 307 
ILE OXT   HXT    sing N N 308 
LEU N     CA     sing N N 309 
LEU N     H      sing N N 310 
LEU N     H2     sing N N 311 
LEU CA    C      sing N N 312 
LEU CA    CB     sing N N 313 
LEU CA    HA     sing N N 314 
LEU C     O      doub N N 315 
LEU C     OXT    sing N N 316 
LEU CB    CG     sing N N 317 
LEU CB    HB2    sing N N 318 
LEU CB    HB3    sing N N 319 
LEU CG    CD1    sing N N 320 
LEU CG    CD2    sing N N 321 
LEU CG    HG     sing N N 322 
LEU CD1   HD11   sing N N 323 
LEU CD1   HD12   sing N N 324 
LEU CD1   HD13   sing N N 325 
LEU CD2   HD21   sing N N 326 
LEU CD2   HD22   sing N N 327 
LEU CD2   HD23   sing N N 328 
LEU OXT   HXT    sing N N 329 
LYS N     CA     sing N N 330 
LYS N     H      sing N N 331 
LYS N     H2     sing N N 332 
LYS CA    C      sing N N 333 
LYS CA    CB     sing N N 334 
LYS CA    HA     sing N N 335 
LYS C     O      doub N N 336 
LYS C     OXT    sing N N 337 
LYS CB    CG     sing N N 338 
LYS CB    HB2    sing N N 339 
LYS CB    HB3    sing N N 340 
LYS CG    CD     sing N N 341 
LYS CG    HG2    sing N N 342 
LYS CG    HG3    sing N N 343 
LYS CD    CE     sing N N 344 
LYS CD    HD2    sing N N 345 
LYS CD    HD3    sing N N 346 
LYS CE    NZ     sing N N 347 
LYS CE    HE2    sing N N 348 
LYS CE    HE3    sing N N 349 
LYS NZ    HZ1    sing N N 350 
LYS NZ    HZ2    sing N N 351 
LYS NZ    HZ3    sing N N 352 
LYS OXT   HXT    sing N N 353 
MET N     CA     sing N N 354 
MET N     H      sing N N 355 
MET N     H2     sing N N 356 
MET CA    C      sing N N 357 
MET CA    CB     sing N N 358 
MET CA    HA     sing N N 359 
MET C     O      doub N N 360 
MET C     OXT    sing N N 361 
MET CB    CG     sing N N 362 
MET CB    HB2    sing N N 363 
MET CB    HB3    sing N N 364 
MET CG    SD     sing N N 365 
MET CG    HG2    sing N N 366 
MET CG    HG3    sing N N 367 
MET SD    CE     sing N N 368 
MET CE    HE1    sing N N 369 
MET CE    HE2    sing N N 370 
MET CE    HE3    sing N N 371 
MET OXT   HXT    sing N N 372 
PHE N     CA     sing N N 373 
PHE N     H      sing N N 374 
PHE N     H2     sing N N 375 
PHE CA    C      sing N N 376 
PHE CA    CB     sing N N 377 
PHE CA    HA     sing N N 378 
PHE C     O      doub N N 379 
PHE C     OXT    sing N N 380 
PHE CB    CG     sing N N 381 
PHE CB    HB2    sing N N 382 
PHE CB    HB3    sing N N 383 
PHE CG    CD1    doub Y N 384 
PHE CG    CD2    sing Y N 385 
PHE CD1   CE1    sing Y N 386 
PHE CD1   HD1    sing N N 387 
PHE CD2   CE2    doub Y N 388 
PHE CD2   HD2    sing N N 389 
PHE CE1   CZ     doub Y N 390 
PHE CE1   HE1    sing N N 391 
PHE CE2   CZ     sing Y N 392 
PHE CE2   HE2    sing N N 393 
PHE CZ    HZ     sing N N 394 
PHE OXT   HXT    sing N N 395 
SER N     CA     sing N N 396 
SER N     H      sing N N 397 
SER N     H2     sing N N 398 
SER CA    C      sing N N 399 
SER CA    CB     sing N N 400 
SER CA    HA     sing N N 401 
SER C     O      doub N N 402 
SER C     OXT    sing N N 403 
SER CB    OG     sing N N 404 
SER CB    HB2    sing N N 405 
SER CB    HB3    sing N N 406 
SER OG    HG     sing N N 407 
SER OXT   HXT    sing N N 408 
THR N     CA     sing N N 409 
THR N     H      sing N N 410 
THR N     H2     sing N N 411 
THR CA    C      sing N N 412 
THR CA    CB     sing N N 413 
THR CA    HA     sing N N 414 
THR C     O      doub N N 415 
THR C     OXT    sing N N 416 
THR CB    OG1    sing N N 417 
THR CB    CG2    sing N N 418 
THR CB    HB     sing N N 419 
THR OG1   HG1    sing N N 420 
THR CG2   HG21   sing N N 421 
THR CG2   HG22   sing N N 422 
THR CG2   HG23   sing N N 423 
THR OXT   HXT    sing N N 424 
TRP N     CA     sing N N 425 
TRP N     H      sing N N 426 
TRP N     H2     sing N N 427 
TRP CA    C      sing N N 428 
TRP CA    CB     sing N N 429 
TRP CA    HA     sing N N 430 
TRP C     O      doub N N 431 
TRP C     OXT    sing N N 432 
TRP CB    CG     sing N N 433 
TRP CB    HB2    sing N N 434 
TRP CB    HB3    sing N N 435 
TRP CG    CD1    doub Y N 436 
TRP CG    CD2    sing Y N 437 
TRP CD1   NE1    sing Y N 438 
TRP CD1   HD1    sing N N 439 
TRP CD2   CE2    doub Y N 440 
TRP CD2   CE3    sing Y N 441 
TRP NE1   CE2    sing Y N 442 
TRP NE1   HE1    sing N N 443 
TRP CE2   CZ2    sing Y N 444 
TRP CE3   CZ3    doub Y N 445 
TRP CE3   HE3    sing N N 446 
TRP CZ2   CH2    doub Y N 447 
TRP CZ2   HZ2    sing N N 448 
TRP CZ3   CH2    sing Y N 449 
TRP CZ3   HZ3    sing N N 450 
TRP CH2   HH2    sing N N 451 
TRP OXT   HXT    sing N N 452 
TYR N     CA     sing N N 453 
TYR N     H      sing N N 454 
TYR N     H2     sing N N 455 
TYR CA    C      sing N N 456 
TYR CA    CB     sing N N 457 
TYR CA    HA     sing N N 458 
TYR C     O      doub N N 459 
TYR C     OXT    sing N N 460 
TYR CB    CG     sing N N 461 
TYR CB    HB2    sing N N 462 
TYR CB    HB3    sing N N 463 
TYR CG    CD1    doub Y N 464 
TYR CG    CD2    sing Y N 465 
TYR CD1   CE1    sing Y N 466 
TYR CD1   HD1    sing N N 467 
TYR CD2   CE2    doub Y N 468 
TYR CD2   HD2    sing N N 469 
TYR CE1   CZ     doub Y N 470 
TYR CE1   HE1    sing N N 471 
TYR CE2   CZ     sing Y N 472 
TYR CE2   HE2    sing N N 473 
TYR CZ    OH     sing N N 474 
TYR OH    HH     sing N N 475 
TYR OXT   HXT    sing N N 476 
VAL N     CA     sing N N 477 
VAL N     H      sing N N 478 
VAL N     H2     sing N N 479 
VAL CA    C      sing N N 480 
VAL CA    CB     sing N N 481 
VAL CA    HA     sing N N 482 
VAL C     O      doub N N 483 
VAL C     OXT    sing N N 484 
VAL CB    CG1    sing N N 485 
VAL CB    CG2    sing N N 486 
VAL CB    HB     sing N N 487 
VAL CG1   HG11   sing N N 488 
VAL CG1   HG12   sing N N 489 
VAL CG1   HG13   sing N N 490 
VAL CG2   HG21   sing N N 491 
VAL CG2   HG22   sing N N 492 
VAL CG2   HG23   sing N N 493 
VAL OXT   HXT    sing N N 494 
# 
loop_
_ndb_struct_conf_na.entry_id 
_ndb_struct_conf_na.feature 
9CK2 'double helix'        
9CK2 'b-form double helix' 
# 
loop_
_ndb_struct_na_base_pair.model_number 
_ndb_struct_na_base_pair.i_label_asym_id 
_ndb_struct_na_base_pair.i_label_comp_id 
_ndb_struct_na_base_pair.i_label_seq_id 
_ndb_struct_na_base_pair.i_symmetry 
_ndb_struct_na_base_pair.j_label_asym_id 
_ndb_struct_na_base_pair.j_label_comp_id 
_ndb_struct_na_base_pair.j_label_seq_id 
_ndb_struct_na_base_pair.j_symmetry 
_ndb_struct_na_base_pair.shear 
_ndb_struct_na_base_pair.stretch 
_ndb_struct_na_base_pair.stagger 
_ndb_struct_na_base_pair.buckle 
_ndb_struct_na_base_pair.propeller 
_ndb_struct_na_base_pair.opening 
_ndb_struct_na_base_pair.pair_number 
_ndb_struct_na_base_pair.pair_name 
_ndb_struct_na_base_pair.i_auth_asym_id 
_ndb_struct_na_base_pair.i_auth_seq_id 
_ndb_struct_na_base_pair.i_PDB_ins_code 
_ndb_struct_na_base_pair.j_auth_asym_id 
_ndb_struct_na_base_pair.j_auth_seq_id 
_ndb_struct_na_base_pair.j_PDB_ins_code 
_ndb_struct_na_base_pair.hbond_type_28 
_ndb_struct_na_base_pair.hbond_type_12 
1 A DT 3  1_555 B DA 15 1_555 -0.075 -0.149 0.017  0.173   -12.024 1.545  1  C_DT3:DA31_D  C 3  ? D 31 ? 20 1 
1 A DA 4  1_555 B DT 14 1_555 0.065  -0.119 0.077  -1.085  -8.098  5.753  2  C_DA4:DT30_D  C 4  ? D 30 ? 20 1 
1 A DA 5  1_555 B DT 13 1_555 -0.001 -0.089 0.148  9.193   -10.369 4.353  3  C_DA5:DT29_D  C 5  ? D 29 ? 20 1 
1 A DG 6  1_555 B DC 12 1_555 -0.157 -0.196 -0.342 -1.697  -12.271 2.754  4  C_DG6:DC28_D  C 6  ? D 28 ? 19 1 
1 A DC 7  1_555 B DG 11 1_555 0.177  -0.097 0.214  -15.087 0.421   0.345  5  C_DC7:DG27_D  C 7  ? D 27 ? 19 1 
1 A DG 8  1_555 B DC 10 1_555 -0.250 -0.132 0.011  10.023  4.089   0.305  6  C_DG8:DC26_D  C 8  ? D 26 ? 19 1 
1 A DG 9  1_555 B DC 9  1_555 -0.292 -0.161 0.160  11.895  -13.023 0.445  7  C_DG9:DC25_D  C 9  ? D 25 ? 19 1 
1 A DA 10 1_555 B DT 8  1_555 0.131  -0.145 0.168  12.311  -17.742 4.109  8  C_DA10:DT24_D C 10 ? D 24 ? 20 1 
1 A DA 11 1_555 B DT 7  1_555 0.106  -0.204 0.150  5.375   -18.356 4.288  9  C_DA11:DT23_D C 11 ? D 23 ? 20 1 
1 A DG 12 1_555 B DC 6  1_555 -0.211 -0.145 0.059  -6.412  -16.304 -0.986 10 C_DG12:DC22_D C 12 ? D 22 ? 19 1 
1 A DT 13 1_555 B DA 5  1_555 -0.086 -0.122 0.151  -5.179  -12.149 5.355  11 C_DT13:DA21_D C 13 ? D 21 ? 20 1 
1 A DG 14 1_555 B DC 4  1_555 0.568  -3.414 -0.655 14.241  5.793   71.485 12 C_DG14:DC20_D C 14 ? D 20 ? ?  3 
1 A DG 15 1_555 B DC 3  1_555 -0.222 -0.121 -0.050 -1.206  -10.344 0.389  13 C_DG15:DC19_D C 15 ? D 19 ? 19 1 
1 A DG 16 1_555 B DC 2  1_555 -0.319 -0.141 -0.208 -12.580 -12.588 1.198  14 C_DG16:DC18_D C 16 ? D 18 ? 19 1 
# 
loop_
_ndb_struct_na_base_pair_step.model_number 
_ndb_struct_na_base_pair_step.i_label_asym_id_1 
_ndb_struct_na_base_pair_step.i_label_comp_id_1 
_ndb_struct_na_base_pair_step.i_label_seq_id_1 
_ndb_struct_na_base_pair_step.i_symmetry_1 
_ndb_struct_na_base_pair_step.j_label_asym_id_1 
_ndb_struct_na_base_pair_step.j_label_comp_id_1 
_ndb_struct_na_base_pair_step.j_label_seq_id_1 
_ndb_struct_na_base_pair_step.j_symmetry_1 
_ndb_struct_na_base_pair_step.i_label_asym_id_2 
_ndb_struct_na_base_pair_step.i_label_comp_id_2 
_ndb_struct_na_base_pair_step.i_label_seq_id_2 
_ndb_struct_na_base_pair_step.i_symmetry_2 
_ndb_struct_na_base_pair_step.j_label_asym_id_2 
_ndb_struct_na_base_pair_step.j_label_comp_id_2 
_ndb_struct_na_base_pair_step.j_label_seq_id_2 
_ndb_struct_na_base_pair_step.j_symmetry_2 
_ndb_struct_na_base_pair_step.shift 
_ndb_struct_na_base_pair_step.slide 
_ndb_struct_na_base_pair_step.rise 
_ndb_struct_na_base_pair_step.tilt 
_ndb_struct_na_base_pair_step.roll 
_ndb_struct_na_base_pair_step.twist 
_ndb_struct_na_base_pair_step.x_displacement 
_ndb_struct_na_base_pair_step.y_displacement 
_ndb_struct_na_base_pair_step.helical_rise 
_ndb_struct_na_base_pair_step.inclination 
_ndb_struct_na_base_pair_step.tip 
_ndb_struct_na_base_pair_step.helical_twist 
_ndb_struct_na_base_pair_step.step_number 
_ndb_struct_na_base_pair_step.step_name 
_ndb_struct_na_base_pair_step.i_auth_asym_id_1 
_ndb_struct_na_base_pair_step.i_auth_seq_id_1 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.j_auth_asym_id_1 
_ndb_struct_na_base_pair_step.j_auth_seq_id_1 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_1 
_ndb_struct_na_base_pair_step.i_auth_asym_id_2 
_ndb_struct_na_base_pair_step.i_auth_seq_id_2 
_ndb_struct_na_base_pair_step.i_PDB_ins_code_2 
_ndb_struct_na_base_pair_step.j_auth_asym_id_2 
_ndb_struct_na_base_pair_step.j_auth_seq_id_2 
_ndb_struct_na_base_pair_step.j_PDB_ins_code_2 
1 A DT 3  1_555 B DA 15 1_555 A DA 4  1_555 B DT 14 1_555 0.454  -0.712 3.226  0.074   9.279    28.842   -3.155 -0.855 2.864  
18.048  -0.143  30.267   1  CC_DT3DA4:DT30DA31_DD   C 3  ? D 31 ? C 4  ? D 30 ? 
1 A DA 4  1_555 B DT 14 1_555 A DA 5  1_555 B DT 13 1_555 -0.326 -0.209 3.082  -0.168  0.592    33.662   -0.451 0.538  3.080  
1.022   0.290   33.668   2  CC_DA4DA5:DT29DT30_DD   C 4  ? D 30 ? C 5  ? D 29 ? 
1 A DA 5  1_555 B DT 13 1_555 A DG 6  1_555 B DC 12 1_555 0.455  -0.990 3.667  1.125   6.465    32.123   -2.973 -0.595 3.422  
11.532  -2.007  32.769   3  CC_DA5DG6:DC28DT29_DD   C 5  ? D 29 ? C 6  ? D 28 ? 
1 A DG 6  1_555 B DC 12 1_555 A DC 7  1_555 B DG 11 1_555 -0.239 -1.226 3.615  -4.835  5.098    31.120   -3.236 -0.518 3.375  
9.354   8.871   31.885   4  CC_DG6DC7:DG27DC28_DD   C 6  ? D 28 ? C 7  ? D 27 ? 
1 A DC 7  1_555 B DG 11 1_555 A DG 8  1_555 B DC 10 1_555 -0.015 -0.290 2.810  2.082   5.813    23.229   -2.287 0.607  2.648  
14.119  -5.057  24.025   5  CC_DC7DG8:DC26DG27_DD   C 7  ? D 27 ? C 8  ? D 26 ? 
1 A DG 8  1_555 B DC 10 1_555 A DG 9  1_555 B DC 9  1_555 -1.064 0.021  3.293  -4.377  3.349    34.973   -0.471 1.088  3.385  
5.530   7.228   35.391   6  CC_DG8DG9:DC25DC26_DD   C 8  ? D 26 ? C 9  ? D 25 ? 
1 A DG 9  1_555 B DC 9  1_555 A DA 10 1_555 B DT 8  1_555 0.130  -0.397 3.206  -0.100  3.755    32.414   -1.342 -0.249 3.141  
6.698   0.179   32.625   7  CC_DG9DA10:DT24DC25_DD  C 9  ? D 25 ? C 10 ? D 24 ? 
1 A DA 10 1_555 B DT 8  1_555 A DA 11 1_555 B DT 7  1_555 0.007  -0.141 3.343  1.492   4.012    33.470   -0.906 0.234  3.301  
6.931   -2.577  33.734   8  CC_DA10DA11:DT23DT24_DD C 10 ? D 24 ? C 11 ? D 23 ? 
1 A DA 11 1_555 B DT 7  1_555 A DG 12 1_555 B DC 6  1_555 -0.130 -0.875 3.501  -2.998  5.582    39.633   -1.946 -0.171 3.353  
8.169   4.387   40.116   9  CC_DA11DG12:DC22DT23_DD C 11 ? D 23 ? C 12 ? D 22 ? 
1 A DG 12 1_555 B DC 6  1_555 A DT 13 1_555 B DA 5  1_555 -0.802 -0.971 3.259  -1.134  1.861    25.770   -2.683 1.480  3.214  
4.164   2.536   25.860   10 CC_DG12DT13:DA21DC22_DD C 12 ? D 22 ? C 13 ? D 21 ? 
1 A DT 13 1_555 B DA 5  1_555 A DG 14 1_555 B DC 4  1_555 -2.232 3.457  -0.722 173.938 -14.340  -129.600 -1.732 -1.151 0.413  
7.191   87.228  -177.671 11 CC_DT13DG14:DC20DA21_DD C 13 ? D 21 ? C 14 ? D 20 ? 
1 A DG 14 1_555 B DC 4  1_555 A DG 15 1_555 B DC 3  1_555 -0.308 -3.777 -0.960 136.225 -106.265 177.444  -1.895 0.146  -0.913 
-53.133 -68.113 179.839  12 CC_DG14DG15:DC19DC20_DD C 14 ? D 20 ? C 15 ? D 19 ? 
1 A DG 15 1_555 B DC 3  1_555 A DG 16 1_555 B DC 2  1_555 0.906  -0.367 3.603  3.306   1.330    31.499   -0.944 -0.981 3.658  
2.440   -6.065  31.695   13 CC_DG15DG16:DC18DC19_DD C 15 ? D 19 ? C 16 ? D 18 ? 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI)' 'United States' HL155178      1 
'National Science Foundation (NSF, United States)'                                    'United States' 'MCB 2028902' 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   8E3K 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 1 21 1' 
_space_group.name_Hall        'P 2yb' 
_space_group.IT_number        4 
_space_group.crystal_system   monoclinic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9CK2 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.023326 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.011677 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.016510 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.025249 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H  ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
NA ? ? 9.38062 1.54875 ? ? 3.38349  72.32734 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P  ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    O  "O5'"  . DA  A 1 1  ? 4.19046   1.36619   32.88537  1.000 18.06380 ? 1   DA  C "O5'"  1 
ATOM   2    C  "C5'"  . DA  A 1 1  ? 3.99121   2.23535   33.97213  1.000 18.54889 ? 1   DA  C "C5'"  1 
ATOM   3    C  "C4'"  . DA  A 1 1  ? 4.85462   3.47629   33.86064  1.000 18.89315 ? 1   DA  C "C4'"  1 
ATOM   4    O  "O4'"  . DA  A 1 1  ? 6.24031   3.12604   34.05706  1.000 19.17756 ? 1   DA  C "O4'"  1 
ATOM   5    C  "C3'"  . DA  A 1 1  ? 4.79531   4.19296   32.52640  1.000 19.76264 ? 1   DA  C "C3'"  1 
ATOM   6    O  "O3'"  . DA  A 1 1  ? 4.90282   5.59531   32.72788  1.000 17.14480 ? 1   DA  C "O3'"  1 
ATOM   7    C  "C2'"  . DA  A 1 1  ? 5.99941   3.63712   31.76716  1.000 16.42327 ? 1   DA  C "C2'"  1 
ATOM   8    C  "C1'"  . DA  A 1 1  ? 7.00309   3.38573   32.88099  1.000 18.85272 ? 1   DA  C "C1'"  1 
ATOM   9    N  N9     . DA  A 1 1  ? 7.86181   2.23069   32.64860  1.000 16.96778 ? 1   DA  C N9     1 
ATOM   10   C  C8     . DA  A 1 1  ? 7.53383   0.92700   32.86151  1.000 17.46276 ? 1   DA  C C8     1 
ATOM   11   N  N7     . DA  A 1 1  ? 8.48116   0.08293   32.56266  1.000 14.84705 ? 1   DA  C N7     1 
ATOM   12   C  C5     . DA  A 1 1  ? 9.52114   0.88876   32.15419  1.000 12.05063 ? 1   DA  C C5     1 
ATOM   13   C  C6     . DA  A 1 1  ? 10.80378  0.58971   31.70493  1.000 11.29525 ? 1   DA  C C6     1 
ATOM   14   N  N6     . DA  A 1 1  ? 11.27833  -0.65295  31.64146  1.000 13.50466 ? 1   DA  C N6     1 
ATOM   15   N  N1     . DA  A 1 1  ? 11.59190  1.61966   31.36479  1.000 12.58741 ? 1   DA  C N1     1 
ATOM   16   C  C2     . DA  A 1 1  ? 11.11579  2.86868   31.44720  1.000 13.81903 ? 1   DA  C C2     1 
ATOM   17   N  N3     . DA  A 1 1  ? 9.91330   3.27815   31.85559  1.000 15.62626 ? 1   DA  C N3     1 
ATOM   18   C  C4     . DA  A 1 1  ? 9.15753   2.22146   32.18670  1.000 12.92672 ? 1   DA  C C4     1 
ATOM   19   H  "H5'"  . DA  A 1 1  ? 4.21091   1.76972   34.79421  1.000 22.25867 ? 1   DA  C "H5'"  1 
ATOM   20   H  "H5''" . DA  A 1 1  ? 3.05843   2.50013   33.99876  1.000 22.25867 ? 1   DA  C "H5''" 1 
ATOM   21   H  "H4'"  . DA  A 1 1  ? 4.59109   4.09891   34.55620  1.000 22.67178 ? 1   DA  C "H4'"  1 
ATOM   22   H  "H3'"  . DA  A 1 1  ? 3.97610   3.96693   32.05872  1.000 23.71517 ? 1   DA  C "H3'"  1 
ATOM   23   H  "H2'"  . DA  A 1 1  ? 5.77488   2.81561   31.30281  1.000 19.70792 ? 1   DA  C "H2'"  1 
ATOM   24   H  "H2''" . DA  A 1 1  ? 6.33889   4.28012   31.12512  1.000 19.70792 ? 1   DA  C "H2''" 1 
ATOM   25   H  "H1'"  . DA  A 1 1  ? 7.54671   4.17974   33.00312  1.000 22.62326 ? 1   DA  C "H1'"  1 
ATOM   26   H  H8     . DA  A 1 1  ? 6.70587   0.66150   33.19151  1.000 20.95531 ? 1   DA  C H8     1 
ATOM   27   H  H61    . DA  A 1 1  ? 12.08680  -0.79183  31.38324  1.000 16.20559 ? 1   DA  C H61    1 
ATOM   28   H  H62    . DA  A 1 1  ? 10.77631  -1.31656  31.85870  1.000 16.20559 ? 1   DA  C H62    1 
ATOM   29   H  H2     . DA  A 1 1  ? 11.70212  3.54105   31.18447  1.000 16.58283 ? 1   DA  C H2     1 
ATOM   30   H  "HO5'" . DA  A 1 1  ? 4.19960   0.53573   33.00734  1.000 21.67656 ? 1   DA  C "HO5'" 1 
ATOM   31   P  P      . DA  A 1 2  ? 4.38934   6.61265   31.60414  1.000 18.71068 ? 2   DA  C P      1 
ATOM   32   O  OP1    . DA  A 1 2  ? 4.12196   7.89896   32.28696  1.000 20.93232 ? 2   DA  C OP1    1 
ATOM   33   O  OP2    . DA  A 1 2  ? 3.38623   5.99727   30.69917  1.000 20.00261 ? 2   DA  C OP2    1 
ATOM   34   O  "O5'"  . DA  A 1 2  ? 5.68912   6.85380   30.69274  1.000 17.95515 ? 2   DA  C "O5'"  1 
ATOM   35   C  "C5'"  . DA  A 1 2  ? 6.75354   7.61844   31.18673  1.000 15.69298 ? 2   DA  C "C5'"  1 
ATOM   36   C  "C4'"  . DA  A 1 2  ? 7.85592   7.73962   30.14433  1.000 19.70980 ? 2   DA  C "C4'"  1 
ATOM   37   O  "O4'"  . DA  A 1 2  ? 8.53667   6.45988   30.00891  1.000 17.91583 ? 2   DA  C "O4'"  1 
ATOM   38   C  "C3'"  . DA  A 1 2  ? 7.39483   8.12025   28.73979  1.000 21.07309 ? 2   DA  C "C3'"  1 
ATOM   39   O  "O3'"  . DA  A 1 2  ? 8.26347   9.11839   28.20718  1.000 21.66638 ? 2   DA  C "O3'"  1 
ATOM   40   C  "C2'"  . DA  A 1 2  ? 7.47026   6.79576   27.96084  1.000 22.40679 ? 2   DA  C "C2'"  1 
ATOM   41   C  "C1'"  . DA  A 1 2  ? 8.64474   6.11467   28.64092  1.000 16.83482 ? 2   DA  C "C1'"  1 
ATOM   42   N  N9     . DA  A 1 2  ? 8.67795   4.65598   28.56680  1.000 16.06080 ? 2   DA  C N9     1 
ATOM   43   C  C8     . DA  A 1 2  ? 7.66147   3.78144   28.85933  1.000 17.36823 ? 2   DA  C C8     1 
ATOM   44   N  N7     . DA  A 1 2  ? 8.00975   2.51685   28.77290  1.000 15.01608 ? 2   DA  C N7     1 
ATOM   45   C  C5     . DA  A 1 2  ? 9.35365   2.56971   28.44075  1.000 14.19680 ? 2   DA  C C5     1 
ATOM   46   C  C6     . DA  A 1 2  ? 10.30446  1.56811   28.20115  1.000 13.89687 ? 2   DA  C C6     1 
ATOM   47   N  N6     . DA  A 1 2  ? 10.02920  0.27686   28.28809  1.000 15.03151 ? 2   DA  C N6     1 
ATOM   48   N  N1     . DA  A 1 2  ? 11.55663  1.95213   27.88511  1.000 14.47833 ? 2   DA  C N1     1 
ATOM   49   C  C2     . DA  A 1 2  ? 11.83029  3.25736   27.81081  1.000 17.53576 ? 2   DA  C C2     1 
ATOM   50   N  N3     . DA  A 1 2  ? 11.01432  4.29435   28.00676  1.000 16.44519 ? 2   DA  C N3     1 
ATOM   51   C  C4     . DA  A 1 2  ? 9.78324   3.87758   28.32458  1.000 15.92808 ? 2   DA  C C4     1 
ATOM   52   H  "H5'"  . DA  A 1 2  ? 7.11039   7.19448   31.98286  1.000 18.83158 ? 2   DA  C "H5'"  1 
ATOM   53   H  "H5''" . DA  A 1 2  ? 6.43200   8.50398   31.41766  1.000 18.83158 ? 2   DA  C "H5''" 1 
ATOM   54   H  "H4'"  . DA  A 1 2  ? 8.49606   8.40424   30.44332  1.000 23.65176 ? 2   DA  C "H4'"  1 
ATOM   55   H  "H3'"  . DA  A 1 2  ? 6.47606   8.43104   28.75244  1.000 25.28771 ? 2   DA  C "H3'"  1 
ATOM   56   H  "H2'"  . DA  A 1 2  ? 6.65466   6.27926   28.05533  1.000 26.88815 ? 2   DA  C "H2'"  1 
ATOM   57   H  "H2''" . DA  A 1 2  ? 7.64174   6.94557   27.01795  1.000 26.88815 ? 2   DA  C "H2''" 1 
ATOM   58   H  "H1'"  . DA  A 1 2  ? 9.45981   6.45628   28.24110  1.000 20.20179 ? 2   DA  C "H1'"  1 
ATOM   59   H  H8     . DA  A 1 2  ? 6.80578   4.05783   29.09664  1.000 20.84187 ? 2   DA  C H8     1 
ATOM   60   H  H61    . DA  A 1 2  ? 10.64585  -0.30493  28.14362  1.000 18.03781 ? 2   DA  C H61    1 
ATOM   61   H  H62    . DA  A 1 2  ? 9.23365   0.01937   28.48908  1.000 18.03781 ? 2   DA  C H62    1 
ATOM   62   H  H2     . DA  A 1 2  ? 12.70850  3.47230   27.59299  1.000 21.04291 ? 2   DA  C H2     1 
ATOM   63   P  P      . DT  A 1 3  ? 7.97007   9.78990   26.78309  1.000 26.50705 ? 3   DT  C P      1 
ATOM   64   O  OP1    . DT  A 1 3  ? 8.57087   11.13674  26.82835  1.000 35.55750 ? 3   DT  C OP1    1 
ATOM   65   O  OP2    . DT  A 1 3  ? 6.58847   9.56939   26.37287  1.000 23.69680 ? 3   DT  C OP2    1 
ATOM   66   O  "O5'"  . DT  A 1 3  ? 8.84064   8.93008   25.75779  1.000 24.34451 ? 3   DT  C "O5'"  1 
ATOM   67   C  "C5'"  . DT  A 1 3  ? 10.20113  8.84476   25.92231  1.000 23.61591 ? 3   DT  C "C5'"  1 
ATOM   68   C  "C4'"  . DT  A 1 3  ? 10.76373  7.80891   24.98839  1.000 26.29874 ? 3   DT  C "C4'"  1 
ATOM   69   O  "O4'"  . DT  A 1 3  ? 10.35700  6.49868   25.41908  1.000 22.55587 ? 3   DT  C "O4'"  1 
ATOM   70   C  "C3'"  . DT  A 1 3  ? 10.28323  7.92174   23.54101  1.000 27.75653 ? 3   DT  C "C3'"  1 
ATOM   71   O  "O3'"  . DT  A 1 3  ? 11.34610  8.36286   22.73372  1.000 29.56005 ? 3   DT  C "O3'"  1 
ATOM   72   C  "C2'"  . DT  A 1 3  ? 9.80766   6.50126   23.18548  1.000 22.83316 ? 3   DT  C "C2'"  1 
ATOM   73   C  "C1'"  . DT  A 1 3  ? 10.42705  5.67506   24.30086  1.000 25.56034 ? 3   DT  C "C1'"  1 
ATOM   74   N  N1     . DT  A 1 3  ? 9.75058   4.39578   24.61593  1.000 15.33624 ? 3   DT  C N1     1 
ATOM   75   C  C2     . DT  A 1 3  ? 10.48420  3.23129   24.54021  1.000 15.73378 ? 3   DT  C C2     1 
ATOM   76   O  O2     . DT  A 1 3  ? 11.66111  3.19503   24.22293  1.000 17.20227 ? 3   DT  C O2     1 
ATOM   77   N  N3     . DT  A 1 3  ? 9.80066   2.11214   24.85813  1.000 14.56759 ? 3   DT  C N3     1 
ATOM   78   C  C4     . DT  A 1 3  ? 8.49768   2.01366   25.25888  1.000 15.01767 ? 3   DT  C C4     1 
ATOM   79   O  O4     . DT  A 1 3  ? 7.97703   0.93554   25.53927  1.000 16.95179 ? 3   DT  C O4     1 
ATOM   80   C  C5     . DT  A 1 3  ? 7.76938   3.25448   25.31112  1.000 18.15291 ? 3   DT  C C5     1 
ATOM   81   C  C7     . DT  A 1 3  ? 6.32195   3.25027   25.71584  1.000 21.59853 ? 3   DT  C C7     1 
ATOM   82   C  C6     . DT  A 1 3  ? 8.43381   4.38481   25.00540  1.000 17.20980 ? 3   DT  C C6     1 
ATOM   83   H  "H5'"  . DT  A 1 3  ? 10.40163  8.59764   26.83862  1.000 28.33909 ? 3   DT  C "H5'"  1 
ATOM   84   H  "H5''" . DT  A 1 3  ? 10.60496  9.70590   25.73188  1.000 28.33909 ? 3   DT  C "H5''" 1 
ATOM   85   H  "H4'"  . DT  A 1 3  ? 11.73211  7.86095   25.00936  1.000 31.55848 ? 3   DT  C "H4'"  1 
ATOM   86   H  "H3'"  . DT  A 1 3  ? 9.52454   8.52286   23.47823  1.000 33.30783 ? 3   DT  C "H3'"  1 
ATOM   87   H  "H2'"  . DT  A 1 3  ? 8.83971   6.43879   23.19312  1.000 27.39980 ? 3   DT  C "H2'"  1 
ATOM   88   H  "H2''" . DT  A 1 3  ? 10.13510  6.22482   22.31527  1.000 27.39980 ? 3   DT  C "H2''" 1 
ATOM   89   H  "H1'"  . DT  A 1 3  ? 11.34422  5.46241   24.06742  1.000 30.67240 ? 3   DT  C "H1'"  1 
ATOM   90   H  H3     . DT  A 1 3  ? 10.23669  1.37300   24.80192  1.000 17.48110 ? 3   DT  C H3     1 
ATOM   91   H  H71    . DT  A 1 3  ? 6.19239   3.89164   26.43191  1.000 25.91823 ? 3   DT  C H71    1 
ATOM   92   H  H72    . DT  A 1 3  ? 5.77922   3.49526   24.95012  1.000 25.91823 ? 3   DT  C H72    1 
ATOM   93   H  H73    . DT  A 1 3  ? 6.08183   2.36124   26.02060  1.000 25.91823 ? 3   DT  C H73    1 
ATOM   94   H  H6     . DT  A 1 3  ? 7.98043   5.19494   25.06049  1.000 20.65176 ? 3   DT  C H6     1 
ATOM   95   P  P      . DA  A 1 4  ? 11.11060  8.66824   21.17373  1.000 29.50706 ? 4   DA  C P      1 
ATOM   96   O  OP1    . DA  A 1 4  ? 12.22695  9.57643   20.82553  1.000 42.58637 ? 4   DA  C OP1    1 
ATOM   97   O  OP2    . DA  A 1 4  ? 9.69877   8.93559   20.84511  1.000 28.61668 ? 4   DA  C OP2    1 
ATOM   98   O  "O5'"  . DA  A 1 4  ? 11.38973  7.25357   20.48616  1.000 26.49361 ? 4   DA  C "O5'"  1 
ATOM   99   C  "C5'"  . DA  A 1 4  ? 12.62149  6.62989   20.69267  1.000 26.21772 ? 4   DA  C "C5'"  1 
ATOM   100  C  "C4'"  . DA  A 1 4  ? 12.61542  5.24246   20.12031  1.000 24.40407 ? 4   DA  C "C4'"  1 
ATOM   101  O  "O4'"  . DA  A 1 4  ? 11.79682  4.37701   20.93678  1.000 25.08778 ? 4   DA  C "O4'"  1 
ATOM   102  C  "C3'"  . DA  A 1 4  ? 12.04632  5.15324   18.69727  1.000 26.50410 ? 4   DA  C "C3'"  1 
ATOM   103  O  "O3'"  . DA  A 1 4  ? 13.11745  4.87091   17.78613  1.000 33.70814 ? 4   DA  C "O3'"  1 
ATOM   104  C  "C2'"  . DA  A 1 4  ? 10.98695  4.04773   18.78040  1.000 30.30038 ? 4   DA  C "C2'"  1 
ATOM   105  C  "C1'"  . DA  A 1 4  ? 11.30285  3.35974   20.11726  1.000 25.49776 ? 4   DA  C "C1'"  1 
ATOM   106  N  N9     . DA  A 1 4  ? 10.16898  2.70285   20.79498  1.000 19.42879 ? 4   DA  C N9     1 
ATOM   107  C  C8     . DA  A 1 4  ? 9.02627   3.26634   21.27327  1.000 22.21311 ? 4   DA  C C8     1 
ATOM   108  N  N7     . DA  A 1 4  ? 8.21321   2.40818   21.85702  1.000 24.84779 ? 4   DA  C N7     1 
ATOM   109  C  C5     . DA  A 1 4  ? 8.88363   1.20453   21.76095  1.000 17.77266 ? 4   DA  C C5     1 
ATOM   110  C  C6     . DA  A 1 4  ? 8.55748   -0.10889  22.17630  1.000 18.02126 ? 4   DA  C C6     1 
ATOM   111  N  N6     . DA  A 1 4  ? 7.43405   -0.42992  22.80006  1.000 20.58936 ? 4   DA  C N6     1 
ATOM   112  N  N1     . DA  A 1 4  ? 9.45762   -1.07183  21.92634  1.000 20.00505 ? 4   DA  C N1     1 
ATOM   113  C  C2     . DA  A 1 4  ? 10.57499  -0.75493  21.29611  1.000 17.38989 ? 4   DA  C C2     1 
ATOM   114  N  N3     . DA  A 1 4  ? 10.99173  0.43505   20.85352  1.000 17.16254 ? 4   DA  C N3     1 
ATOM   115  C  C4     . DA  A 1 4  ? 10.08964  1.37264   21.12348  1.000 14.92446 ? 4   DA  C C4     1 
ATOM   116  H  "H5'"  . DA  A 1 4  ? 12.80119  6.58292   21.64472  1.000 31.46126 ? 4   DA  C "H5'"  1 
ATOM   117  H  "H5''" . DA  A 1 4  ? 13.31963  7.14992   20.26479  1.000 31.46126 ? 4   DA  C "H5''" 1 
ATOM   118  H  "H4'"  . DA  A 1 4  ? 13.51796  4.88709   20.12547  1.000 29.28488 ? 4   DA  C "H4'"  1 
ATOM   119  H  "H3'"  . DA  A 1 4  ? 11.59239  5.97329   18.44754  1.000 31.80492 ? 4   DA  C "H3'"  1 
ATOM   120  H  "H2'"  . DA  A 1 4  ? 10.09145  4.42052   18.78168  1.000 36.36045 ? 4   DA  C "H2'"  1 
ATOM   121  H  "H2''" . DA  A 1 4  ? 11.06969  3.42730   18.03937  1.000 36.36045 ? 4   DA  C "H2''" 1 
ATOM   122  H  "H1'"  . DA  A 1 4  ? 11.97451  2.67611   19.96751  1.000 30.59731 ? 4   DA  C "H1'"  1 
ATOM   123  H  H8     . DA  A 1 4  ? 8.83635   4.17341   21.19550  1.000 26.65573 ? 4   DA  C H8     1 
ATOM   124  H  H61    . DA  A 1 4  ? 7.29161   -1.24412  23.03752  1.000 24.70723 ? 4   DA  C H61    1 
ATOM   125  H  H62    . DA  A 1 4  ? 6.84703   0.17583   22.96761  1.000 24.70723 ? 4   DA  C H62    1 
ATOM   126  H  H2     . DA  A 1 4  ? 11.15613  -1.46345  21.13744  1.000 20.86786 ? 4   DA  C H2     1 
ATOM   127  P  P      . DA  A 1 5  ? 12.89636  4.91305   16.19244  1.000 28.99769 ? 5   DA  C P      1 
ATOM   128  O  OP1    . DA  A 1 5  ? 14.10031  5.55208   15.63850  1.000 31.86924 ? 5   DA  C OP1    1 
ATOM   129  O  OP2    . DA  A 1 5  ? 11.57981  5.44703   15.86561  1.000 24.22814 ? 5   DA  C OP2    1 
ATOM   130  O  "O5'"  . DA  A 1 5  ? 12.91270  3.37003   15.82666  1.000 23.70431 ? 5   DA  C "O5'"  1 
ATOM   131  C  "C5'"  . DA  A 1 5  ? 14.02488  2.62285   16.21524  1.000 20.62486 ? 5   DA  C "C5'"  1 
ATOM   132  C  "C4'"  . DA  A 1 5  ? 13.76890  1.14824   16.07272  1.000 18.51098 ? 5   DA  C "C4'"  1 
ATOM   133  O  "O4'"  . DA  A 1 5  ? 12.73285  0.74637   17.00529  1.000 21.58649 ? 5   DA  C "O4'"  1 
ATOM   134  C  "C3'"  . DA  A 1 5  ? 13.31491  0.70460   14.69168  1.000 18.90476 ? 5   DA  C "C3'"  1 
ATOM   135  O  "O3'"  . DA  A 1 5  ? 14.13288  -0.38939  14.28601  1.000 22.83924 ? 5   DA  C "O3'"  1 
ATOM   136  C  "C2'"  . DA  A 1 5  ? 11.83206  0.34263   14.88829  1.000 21.16351 ? 5   DA  C "C2'"  1 
ATOM   137  C  "C1'"  . DA  A 1 5  ? 11.78989  -0.07801  16.34687  1.000 20.64733 ? 5   DA  C "C1'"  1 
ATOM   138  N  N9     . DA  A 1 5  ? 10.50104  0.07684   17.01505  1.000 16.21764 ? 5   DA  C N9     1 
ATOM   139  C  C8     . DA  A 1 5  ? 9.71198   1.18598   17.07997  1.000 18.22832 ? 5   DA  C C8     1 
ATOM   140  N  N7     . DA  A 1 5  ? 8.61561   1.01568   17.78576  1.000 18.27372 ? 5   DA  C N7     1 
ATOM   141  C  C5     . DA  A 1 5  ? 8.69069   -0.30806  18.19830  1.000 15.87089 ? 5   DA  C C5     1 
ATOM   142  C  C6     . DA  A 1 5  ? 7.83714   -1.11785  18.98698  1.000 18.62452 ? 5   DA  C C6     1 
ATOM   143  N  N6     . DA  A 1 5  ? 6.67883   -0.70023  19.50783  1.000 18.68537 ? 5   DA  C N6     1 
ATOM   144  N  N1     . DA  A 1 5  ? 8.21798   -2.39116  19.20296  1.000 16.61911 ? 5   DA  C N1     1 
ATOM   145  C  C2     . DA  A 1 5  ? 9.36272   -2.81800  18.68181  1.000 17.43029 ? 5   DA  C C2     1 
ATOM   146  N  N3     . DA  A 1 5  ? 10.25112  -2.15475  17.94621  1.000 18.99969 ? 5   DA  C N3     1 
ATOM   147  C  C4     . DA  A 1 5  ? 9.83691   -0.89567  17.72850  1.000 16.06719 ? 5   DA  C C4     1 
ATOM   148  H  "H5'"  . DA  A 1 5  ? 14.23319  2.82122   17.14161  1.000 24.74983 ? 5   DA  C "H5'"  1 
ATOM   149  H  "H5''" . DA  A 1 5  ? 14.78235  2.86894   15.66154  1.000 24.74983 ? 5   DA  C "H5''" 1 
ATOM   150  H  "H4'"  . DA  A 1 5  ? 14.57651  0.65840   16.29345  1.000 22.21318 ? 5   DA  C "H4'"  1 
ATOM   151  H  "H3'"  . DA  A 1 5  ? 13.35622  1.42626   14.04484  1.000 22.68571 ? 5   DA  C "H3'"  1 
ATOM   152  H  "H2'"  . DA  A 1 5  ? 11.25747  1.10678   14.72454  1.000 25.39621 ? 5   DA  C "H2'"  1 
ATOM   153  H  "H2''" . DA  A 1 5  ? 11.56554  -0.38396  14.30354  1.000 25.39621 ? 5   DA  C "H2''" 1 
ATOM   154  H  "H1'"  . DA  A 1 5  ? 12.04363  -1.01241  16.40533  1.000 24.77680 ? 5   DA  C "H1'"  1 
ATOM   155  H  H8     . DA  A 1 5  ? 9.92876   1.98888   16.66373  1.000 21.87399 ? 5   DA  C H8     1 
ATOM   156  H  H61    . DA  A 1 5  ? 6.19497   -1.24114  19.96924  1.000 22.42244 ? 5   DA  C H61    1 
ATOM   157  H  H62    . DA  A 1 5  ? 6.41758   0.10933   19.38146  1.000 22.42244 ? 5   DA  C H62    1 
ATOM   158  H  H2     . DA  A 1 5  ? 9.57323   -3.70698  18.85587  1.000 20.91635 ? 5   DA  C H2     1 
ATOM   159  P  P      . DG  A 1 6  ? 14.05910  -0.98340  12.79431  1.000 22.42591 ? 6   DG  C P      1 
ATOM   160  O  OP1    . DG  A 1 6  ? 15.33851  -1.73284  12.70158  1.000 20.98148 ? 6   DG  C OP1    1 
ATOM   161  O  OP2    . DG  A 1 6  ? 13.71779  0.02656   11.78942  1.000 22.89985 ? 6   DG  C OP2    1 
ATOM   162  O  "O5'"  . DG  A 1 6  ? 12.88920  -2.05892  12.91924  1.000 21.05971 ? 6   DG  C "O5'"  1 
ATOM   163  C  "C5'"  . DG  A 1 6  ? 13.11105  -3.13751  13.80140  1.000 18.03944 ? 6   DG  C "C5'"  1 
ATOM   164  C  "C4'"  . DG  A 1 6  ? 11.89206  -4.00990  13.92687  1.000 23.12567 ? 6   DG  C "C4'"  1 
ATOM   165  O  "O4'"  . DG  A 1 6  ? 10.91429  -3.34359  14.72395  1.000 23.35549 ? 6   DG  C "O4'"  1 
ATOM   166  C  "C3'"  . DG  A 1 6  ? 11.19658  -4.34928  12.60268  1.000 21.92802 ? 6   DG  C "C3'"  1 
ATOM   167  O  "O3'"  . DG  A 1 6  ? 11.41717  -5.69589  12.30401  1.000 26.97523 ? 6   DG  C "O3'"  1 
ATOM   168  C  "C2'"  . DG  A 1 6  ? 9.70657   -4.04371  12.86008  1.000 21.00268 ? 6   DG  C "C2'"  1 
ATOM   169  C  "C1'"  . DG  A 1 6  ? 9.65813   -3.86854  14.36462  1.000 22.69380 ? 6   DG  C "C1'"  1 
ATOM   170  N  N9     . DG  A 1 6  ? 8.61649   -2.97435  14.83754  1.000 19.29166 ? 6   DG  C N9     1 
ATOM   171  C  C8     . DG  A 1 6  ? 8.48867   -1.62729  14.61481  1.000 21.44912 ? 6   DG  C C8     1 
ATOM   172  N  N7     . DG  A 1 6  ? 7.44224   -1.10657  15.20019  1.000 19.68412 ? 6   DG  C N7     1 
ATOM   173  C  C5     . DG  A 1 6  ? 6.84200   -2.17867  15.83867  1.000 17.98007 ? 6   DG  C C5     1 
ATOM   174  C  C6     . DG  A 1 6  ? 5.65139   -2.24298  16.62047  1.000 17.84633 ? 6   DG  C C6     1 
ATOM   175  O  O6     . DG  A 1 6  ? 4.88150   -1.33323  16.91903  1.000 22.74687 ? 6   DG  C O6     1 
ATOM   176  N  N1     . DG  A 1 6  ? 5.40903   -3.52943  17.07121  1.000 19.27799 ? 6   DG  C N1     1 
ATOM   177  C  C2     . DG  A 1 6  ? 6.20780   -4.61507  16.79936  1.000 16.14725 ? 6   DG  C C2     1 
ATOM   178  N  N2     . DG  A 1 6  ? 5.83292   -5.78419  17.31763  1.000 22.32701 ? 6   DG  C N2     1 
ATOM   179  N  N3     . DG  A 1 6  ? 7.31582   -4.56012  16.07096  1.000 19.30596 ? 6   DG  C N3     1 
ATOM   180  C  C4     . DG  A 1 6  ? 7.55965   -3.32697  15.63071  1.000 16.19523 ? 6   DG  C C4     1 
ATOM   181  H  "H5'"  . DG  A 1 6  ? 13.34206  -2.78849  14.67646  1.000 21.64733 ? 6   DG  C "H5'"  1 
ATOM   182  H  "H5''" . DG  A 1 6  ? 13.84967  -3.67140  13.46929  1.000 21.64733 ? 6   DG  C "H5''" 1 
ATOM   183  H  "H4'"  . DG  A 1 6  ? 12.13874  -4.83888  14.36602  1.000 27.75080 ? 6   DG  C "H4'"  1 
ATOM   184  H  "H3'"  . DG  A 1 6  ? 11.51547  -3.76872  11.89405  1.000 26.31362 ? 6   DG  C "H3'"  1 
ATOM   185  H  "H2'"  . DG  A 1 6  ? 9.42911   -3.23468  12.40250  1.000 25.20322 ? 6   DG  C "H2'"  1 
ATOM   186  H  "H2''" . DG  A 1 6  ? 9.14198   -4.77836  12.57298  1.000 25.20322 ? 6   DG  C "H2''" 1 
ATOM   187  H  "H1'"  . DG  A 1 6  ? 9.52630   -4.73185  14.78677  1.000 27.23256 ? 6   DG  C "H1'"  1 
ATOM   188  H  H8     . DG  A 1 6  ? 9.08574   -1.13431  14.09966  1.000 25.73894 ? 6   DG  C H8     1 
ATOM   189  H  H1     . DG  A 1 6  ? 4.70991   -3.65853  17.55512  1.000 23.13359 ? 6   DG  C H1     1 
ATOM   190  H  H21    . DG  A 1 6  ? 6.30675   -6.48817  17.17801  1.000 26.79241 ? 6   DG  C H21    1 
ATOM   191  H  H22    . DG  A 1 6  ? 5.11716   -5.83468  17.79170  1.000 26.79241 ? 6   DG  C H22    1 
ATOM   192  P  P      . DC  A 1 7  ? 10.98130  -6.31476  10.89417  1.000 22.74849 ? 7   DC  C P      1 
ATOM   193  O  OP1    . DC  A 1 7  ? 11.88411  -7.48068  10.71838  1.000 28.66025 ? 7   DC  C OP1    1 
ATOM   194  O  OP2    . DC  A 1 7  ? 10.84554  -5.32329  9.83701   1.000 21.82220 ? 7   DC  C OP2    1 
ATOM   195  O  "O5'"  . DC  A 1 7  ? 9.50452   -6.87346  11.19516  1.000 20.16851 ? 7   DC  C "O5'"  1 
ATOM   196  C  "C5'"  . DC  A 1 7  ? 9.31797   -7.74133  12.29136  1.000 22.61026 ? 7   DC  C "C5'"  1 
ATOM   197  C  "C4'"  . DC  A 1 7  ? 7.85247   -7.97873  12.54233  1.000 20.75803 ? 7   DC  C "C4'"  1 
ATOM   198  O  "O4'"  . DC  A 1 7  ? 7.29277   -6.86428  13.21850  1.000 21.55283 ? 7   DC  C "O4'"  1 
ATOM   199  C  "C3'"  . DC  A 1 7  ? 6.99046   -8.13801  11.28306  1.000 20.02687 ? 7   DC  C "C3'"  1 
ATOM   200  O  "O3'"  . DC  A 1 7  ? 6.86743   -9.48780  10.96341  1.000 23.75279 ? 7   DC  C "O3'"  1 
ATOM   201  C  "C2'"  . DC  A 1 7  ? 5.64855   -7.51502  11.66325  1.000 21.94390 ? 7   DC  C "C2'"  1 
ATOM   202  C  "C1'"  . DC  A 1 7  ? 5.89588   -6.92750  13.04643  1.000 21.54664 ? 7   DC  C "C1'"  1 
ATOM   203  N  N1     . DC  A 1 7  ? 5.34379   -5.59626  13.23284  1.000 17.02858 ? 7   DC  C N1     1 
ATOM   204  C  C2     . DC  A 1 7  ? 4.07105   -5.46802  13.79738  1.000 16.91223 ? 7   DC  C C2     1 
ATOM   205  O  O2     . DC  A 1 7  ? 3.43975   -6.49563  14.09629  1.000 17.86528 ? 7   DC  C O2     1 
ATOM   206  N  N3     . DC  A 1 7  ? 3.56679   -4.23901  13.99469  1.000 18.00597 ? 7   DC  C N3     1 
ATOM   207  C  C4     . DC  A 1 7  ? 4.26541   -3.16321  13.64821  1.000 15.13112 ? 7   DC  C C4     1 
ATOM   208  N  N4     . DC  A 1 7  ? 3.71886   -1.96732  13.89433  1.000 19.58166 ? 7   DC  C N4     1 
ATOM   209  C  C5     . DC  A 1 7  ? 5.56716   -3.26577  13.06933  1.000 18.53054 ? 7   DC  C C5     1 
ATOM   210  C  C6     . DC  A 1 7  ? 6.06900   -4.49497  12.89058  1.000 17.45183 ? 7   DC  C C6     1 
ATOM   211  H  "H5'"  . DC  A 1 7  ? 9.71830   -7.34792  13.08248  1.000 27.13232 ? 7   DC  C "H5'"  1 
ATOM   212  H  "H5''" . DC  A 1 7  ? 9.75206   -8.58871  12.10588  1.000 27.13232 ? 7   DC  C "H5''" 1 
ATOM   213  H  "H4'"  . DC  A 1 7  ? 7.76407   -8.76970  13.09682  1.000 24.90963 ? 7   DC  C "H4'"  1 
ATOM   214  H  "H3'"  . DC  A 1 7  ? 7.37981   -7.63628  10.54986  1.000 24.03224 ? 7   DC  C "H3'"  1 
ATOM   215  H  "H2'"  . DC  A 1 7  ? 5.39601   -6.82292  11.03228  1.000 26.33268 ? 7   DC  C "H2'"  1 
ATOM   216  H  "H2''" . DC  A 1 7  ? 4.94953   -8.18694  11.69150  1.000 26.33268 ? 7   DC  C "H2''" 1 
ATOM   217  H  "H1'"  . DC  A 1 7  ? 5.51893   -7.52309  13.71282  1.000 25.85597 ? 7   DC  C "H1'"  1 
ATOM   218  H  H41    . DC  A 1 7  ? 4.14256   -1.24928  13.68339  1.000 23.49799 ? 7   DC  C H41    1 
ATOM   219  H  H42    . DC  A 1 7  ? 2.94379   -1.91653  14.26349  1.000 23.49799 ? 7   DC  C H42    1 
ATOM   220  H  H5     . DC  A 1 7  ? 6.04812   -2.50798  12.82574  1.000 22.23665 ? 7   DC  C H5     1 
ATOM   221  H  H6     . DC  A 1 7  ? 6.91997   -4.59738  12.52966  1.000 20.94220 ? 7   DC  C H6     1 
ATOM   222  P  P      . DG  A 1 8  ? 6.32477   -9.94129  9.52281   1.000 24.17812 ? 8   DG  C P      1 
ATOM   223  O  OP1    . DG  A 1 8  ? 6.76574   -11.34969 9.43721   1.000 24.63957 ? 8   DG  C OP1    1 
ATOM   224  O  OP2    . DG  A 1 8  ? 6.66747   -8.98031  8.46247   1.000 22.14231 ? 8   DG  C OP2    1 
ATOM   225  O  "O5'"  . DG  A 1 8  ? 4.73722   -9.86233  9.67636   1.000 20.67842 ? 8   DG  C "O5'"  1 
ATOM   226  C  "C5'"  . DG  A 1 8  ? 4.06963   -10.68440 10.59439  1.000 17.86040 ? 8   DG  C "C5'"  1 
ATOM   227  C  "C4'"  . DG  A 1 8  ? 2.58953   -10.36055 10.57127  1.000 16.67424 ? 8   DG  C "C4'"  1 
ATOM   228  O  "O4'"  . DG  A 1 8  ? 2.36930   -9.06647  11.19532  1.000 17.45323 ? 8   DG  C "O4'"  1 
ATOM   229  C  "C3'"  . DG  A 1 8  ? 2.00114   -10.22674 9.16135   1.000 19.80692 ? 8   DG  C "C3'"  1 
ATOM   230  O  "O3'"  . DG  A 1 8  ? 0.69073   -10.64522 9.13579   1.000 19.60895 ? 8   DG  C "O3'"  1 
ATOM   231  C  "C2'"  . DG  A 1 8  ? 2.06057   -8.74143  8.92895   1.000 20.35172 ? 8   DG  C "C2'"  1 
ATOM   232  C  "C1'"  . DG  A 1 8  ? 1.63168   -8.27380  10.29754  1.000 19.79015 ? 8   DG  C "C1'"  1 
ATOM   233  N  N9     . DG  A 1 8  ? 1.85505   -6.86121  10.53823  1.000 16.29013 ? 8   DG  C N9     1 
ATOM   234  C  C8     . DG  A 1 8  ? 2.87575   -6.07260  10.05434  1.000 15.89384 ? 8   DG  C C8     1 
ATOM   235  N  N7     . DG  A 1 8  ? 2.77214   -4.82437  10.41532  1.000 12.75630 ? 8   DG  C N7     1 
ATOM   236  C  C5     . DG  A 1 8  ? 1.60924   -4.79786  11.19037  1.000 12.59074 ? 8   DG  C C5     1 
ATOM   237  C  C6     . DG  A 1 8  ? 0.97261   -3.73263  11.86072  1.000 14.64793 ? 8   DG  C C6     1 
ATOM   238  O  O6     . DG  A 1 8  ? 1.30648   -2.54193  11.90342  1.000 13.65546 ? 8   DG  C O6     1 
ATOM   239  N  N1     . DG  A 1 8  ? -0.18809  -4.16114  12.52536  1.000 15.12829 ? 8   DG  C N1     1 
ATOM   240  C  C2     . DG  A 1 8  ? -0.64497  -5.45320  12.54948  1.000 12.97924 ? 8   DG  C C2     1 
ATOM   241  N  N2     . DG  A 1 8  ? -1.78815  -5.68456  13.22674  1.000 17.46234 ? 8   DG  C N2     1 
ATOM   242  N  N3     . DG  A 1 8  ? -0.05282  -6.44736  11.93366  1.000 12.86622 ? 8   DG  C N3     1 
ATOM   243  C  C4     . DG  A 1 8  ? 1.05322   -6.05032  11.26920  1.000 14.77172 ? 8   DG  C C4     1 
ATOM   244  H  "H5'"  . DG  A 1 8  ? 4.42275   -10.53250 11.48496  1.000 21.43249 ? 8   DG  C "H5'"  1 
ATOM   245  H  "H5''" . DG  A 1 8  ? 4.20350   -11.61510 10.35609  1.000 21.43249 ? 8   DG  C "H5''" 1 
ATOM   246  H  "H4'"  . DG  A 1 8  ? 2.10337   -11.03741 11.06765  1.000 20.00909 ? 8   DG  C "H4'"  1 
ATOM   247  H  "H3'"  . DG  A 1 8  ? 2.54520   -10.72334 8.53024   1.000 23.76830 ? 8   DG  C "H3'"  1 
ATOM   248  H  "H2'"  . DG  A 1 8  ? 2.95500   -8.44159  8.70315   1.000 24.42206 ? 8   DG  C "H2'"  1 
ATOM   249  H  "H2''" . DG  A 1 8  ? 1.44668   -8.45451  8.23489   1.000 24.42206 ? 8   DG  C "H2''" 1 
ATOM   250  H  "H1'"  . DG  A 1 8  ? 0.68615   -8.43570  10.44126  1.000 23.74818 ? 8   DG  C "H1'"  1 
ATOM   251  H  H8     . DG  A 1 8  ? 3.56764   -6.39743  9.52455   1.000 19.07261 ? 8   DG  C H8     1 
ATOM   252  H  H1     . DG  A 1 8  ? -0.64612  -3.56894  12.94858  1.000 18.15394 ? 8   DG  C H1     1 
ATOM   253  H  H21    . DG  A 1 8  ? -2.12059  -6.47733  13.25110  1.000 20.95481 ? 8   DG  C H21    1 
ATOM   254  H  H22    . DG  A 1 8  ? -2.18464  -5.03931  13.63423  1.000 20.95481 ? 8   DG  C H22    1 
ATOM   255  P  P      . DG  A 1 9  ? 0.27573   -11.99185 8.39254   1.000 23.81145 ? 9   DG  C P      1 
ATOM   256  O  OP1    . DG  A 1 9  ? 1.00864   -13.09871 9.03324   1.000 30.07661 ? 9   DG  C OP1    1 
ATOM   257  O  OP2    . DG  A 1 9  ? 0.35122   -11.76301 6.94857   1.000 27.05763 ? 9   DG  C OP2    1 
ATOM   258  O  "O5'"  . DG  A 1 9  ? -1.24820  -12.09373 8.80499   1.000 24.91590 ? 9   DG  C "O5'"  1 
ATOM   259  C  "C5'"  . DG  A 1 9  ? -1.57405  -12.18884 10.17666  1.000 22.70150 ? 9   DG  C "C5'"  1 
ATOM   260  C  "C4'"  . DG  A 1 9  ? -2.87666  -11.48934 10.48744  1.000 23.24618 ? 9   DG  C "C4'"  1 
ATOM   261  O  "O4'"  . DG  A 1 9  ? -2.64115  -10.06726 10.65957  1.000 23.79202 ? 9   DG  C "O4'"  1 
ATOM   262  C  "C3'"  . DG  A 1 9  ? -3.95153  -11.59969 9.42545   1.000 25.91003 ? 9   DG  C "C3'"  1 
ATOM   263  O  "O3'"  . DG  A 1 9  ? -5.18202  -11.82462 10.07454  1.000 25.40169 ? 9   DG  C "O3'"  1 
ATOM   264  C  "C2'"  . DG  A 1 9  ? -3.88167  -10.24586 8.69511   1.000 18.31284 ? 9   DG  C "C2'"  1 
ATOM   265  C  "C1'"  . DG  A 1 9  ? -3.49023  -9.30956  9.81318   1.000 20.22088 ? 9   DG  C "C1'"  1 
ATOM   266  N  N9     . DG  A 1 9  ? -2.72784  -8.12340  9.42700   1.000 15.59797 ? 9   DG  C N9     1 
ATOM   267  C  C8     . DG  A 1 9  ? -1.57849  -8.08816  8.70178   1.000 15.55485 ? 9   DG  C C8     1 
ATOM   268  N  N7     . DG  A 1 9  ? -1.08331  -6.88494  8.56700   1.000 15.03417 ? 9   DG  C N7     1 
ATOM   269  C  C5     . DG  A 1 9  ? -1.94696  -6.07877  9.28091   1.000 13.84154 ? 9   DG  C C5     1 
ATOM   270  C  C6     . DG  A 1 9  ? -1.92503  -4.68124  9.50238   1.000 11.59441 ? 9   DG  C C6     1 
ATOM   271  O  O6     . DG  A 1 9  ? -1.06770  -3.84716  9.13285   1.000 12.55613 ? 9   DG  C O6     1 
ATOM   272  N  N1     . DG  A 1 9  ? -2.99882  -4.27925  10.29544  1.000 14.54746 ? 9   DG  C N1     1 
ATOM   273  C  C2     . DG  A 1 9  ? -3.97318  -5.13422  10.78807  1.000 15.76936 ? 9   DG  C C2     1 
ATOM   274  N  N2     . DG  A 1 9  ? -4.95849  -4.58219  11.51665  1.000 17.21434 ? 9   DG  C N2     1 
ATOM   275  N  N3     . DG  A 1 9  ? -3.98031  -6.43241  10.58805  1.000 13.76940 ? 9   DG  C N3     1 
ATOM   276  C  C4     . DG  A 1 9  ? -2.95940  -6.83285  9.82903   1.000 12.57499 ? 9   DG  C C4     1 
ATOM   277  H  "H5'"  . DG  A 1 9  ? -0.86445  -11.78408 10.69967  1.000 27.24180 ? 9   DG  C "H5'"  1 
ATOM   278  H  "H5''" . DG  A 1 9  ? -1.65113  -13.12470 10.41983  1.000 27.24180 ? 9   DG  C "H5''" 1 
ATOM   279  H  "H4'"  . DG  A 1 9  ? -3.22697  -11.85136 11.31637  1.000 27.89541 ? 9   DG  C "H4'"  1 
ATOM   280  H  "H3'"  . DG  A 1 9  ? -3.75909  -12.29952 8.78194   1.000 31.09204 ? 9   DG  C "H3'"  1 
ATOM   281  H  "H2'"  . DG  A 1 9  ? -3.21458  -10.25638 7.99099   1.000 21.97541 ? 9   DG  C "H2'"  1 
ATOM   282  H  "H2''" . DG  A 1 9  ? -4.73992  -10.00373 8.31343   1.000 21.97541 ? 9   DG  C "H2''" 1 
ATOM   283  H  "H1'"  . DG  A 1 9  ? -4.30510  -9.02625  10.25661  1.000 24.26506 ? 9   DG  C "H1'"  1 
ATOM   284  H  H8     . DG  A 1 9  ? -1.18250  -8.84633  8.33673   1.000 18.66582 ? 9   DG  C H8     1 
ATOM   285  H  H1     . DG  A 1 9  ? -3.06118  -3.44446  10.49252  1.000 17.45695 ? 9   DG  C H1     1 
ATOM   286  H  H21    . DG  A 1 9  ? -5.58075  -5.07760  11.84371  1.000 20.65720 ? 9   DG  C H21    1 
ATOM   287  H  H22    . DG  A 1 9  ? -4.96670  -3.73356  11.65579  1.000 20.65720 ? 9   DG  C H22    1 
ATOM   288  P  P      . DA  A 1 10 ? -6.47961  -12.31870 9.27527   1.000 24.37033 ? 10  DA  C P      1 
ATOM   289  O  OP1    . DA  A 1 10 ? -7.29886  -12.96994 10.30892  1.000 28.32018 ? 10  DA  C OP1    1 
ATOM   290  O  OP2    . DA  A 1 10 ? -6.15017  -12.92340 7.97883   1.000 25.22315 ? 10  DA  C OP2    1 
ATOM   291  O  "O5'"  . DA  A 1 10 ? -7.19993  -10.93466 8.92201   1.000 20.95552 ? 10  DA  C "O5'"  1 
ATOM   292  C  "C5'"  . DA  A 1 10 ? -7.63503  -10.13611 9.98389   1.000 21.19687 ? 10  DA  C "C5'"  1 
ATOM   293  C  "C4'"  . DA  A 1 10 ? -8.06171  -8.79625  9.47794   1.000 29.11222 ? 10  DA  C "C4'"  1 
ATOM   294  O  "O4'"  . DA  A 1 10 ? -6.90672  -8.03611  9.10599   1.000 24.18595 ? 10  DA  C "O4'"  1 
ATOM   295  C  "C3'"  . DA  A 1 10 ? -8.94386  -8.85732  8.23405   1.000 23.49695 ? 10  DA  C "C3'"  1 
ATOM   296  O  "O3'"  . DA  A 1 10 ? -10.25656 -8.45835  8.59216   1.000 28.21234 ? 10  DA  C "O3'"  1 
ATOM   297  C  "C2'"  . DA  A 1 10 ? -8.26504  -7.91104  7.22578   1.000 29.50260 ? 10  DA  C "C2'"  1 
ATOM   298  C  "C1'"  . DA  A 1 10 ? -7.28610  -7.13438  8.11308   1.000 21.58846 ? 10  DA  C "C1'"  1 
ATOM   299  N  N9     . DA  A 1 10 ? -6.05889  -6.65263  7.48733   1.000 19.98128 ? 10  DA  C N9     1 
ATOM   300  C  C8     . DA  A 1 10 ? -5.11830  -7.37302  6.80678   1.000 15.51437 ? 10  DA  C C8     1 
ATOM   301  N  N7     . DA  A 1 10 ? -4.09127  -6.66625  6.42130   1.000 16.63116 ? 10  DA  C N7     1 
ATOM   302  C  C5     . DA  A 1 10 ? -4.37097  -5.39910  6.89701   1.000 16.06890 ? 10  DA  C C5     1 
ATOM   303  C  C6     . DA  A 1 10 ? -3.66854  -4.17425  6.82288   1.000 14.57521 ? 10  DA  C C6     1 
ATOM   304  N  N6     . DA  A 1 10 ? -2.50684  -4.03489  6.21326   1.000 15.36605 ? 10  DA  C N6     1 
ATOM   305  N  N1     . DA  A 1 10 ? -4.22544  -3.10668  7.40828   1.000 13.53887 ? 10  DA  C N1     1 
ATOM   306  C  C2     . DA  A 1 10 ? -5.39462  -3.24337  8.01900   1.000 14.08541 ? 10  DA  C C2     1 
ATOM   307  N  N3     . DA  A 1 10 ? -6.14067  -4.33659  8.17034   1.000 16.53873 ? 10  DA  C N3     1 
ATOM   308  C  C4     . DA  A 1 10 ? -5.56581  -5.38419  7.57063   1.000 15.63934 ? 10  DA  C C4     1 
ATOM   309  H  "H5'"  . DA  A 1 10 ? -6.91236  -10.02512 10.62133  1.000 25.43624 ? 10  DA  C "H5'"  1 
ATOM   310  H  "H5''" . DA  A 1 10 ? -8.38298  -10.56708 10.42632  1.000 25.43624 ? 10  DA  C "H5''" 1 
ATOM   311  H  "H4'"  . DA  A 1 10 ? -8.52792  -8.31396  10.17861  1.000 34.93467 ? 10  DA  C "H4'"  1 
ATOM   312  H  "H3'"  . DA  A 1 10 ? -8.94005  -9.74669  7.84686   1.000 28.19634 ? 10  DA  C "H3'"  1 
ATOM   313  H  "H2'"  . DA  A 1 10 ? -7.79837  -8.40696  6.53500   1.000 35.40312 ? 10  DA  C "H2'"  1 
ATOM   314  H  "H2''" . DA  A 1 10 ? -8.90967  -7.31850  6.80835   1.000 35.40312 ? 10  DA  C "H2''" 1 
ATOM   315  H  "H1'"  . DA  A 1 10 ? -7.75940  -6.36380  8.46393   1.000 25.90615 ? 10  DA  C "H1'"  1 
ATOM   316  H  H8     . DA  A 1 10 ? -5.20226  -8.28300  6.63420   1.000 18.61724 ? 10  DA  C H8     1 
ATOM   317  H  H61    . DA  A 1 10 ? -2.11946  -3.26726  6.19636   1.000 18.43926 ? 10  DA  C H61    1 
ATOM   318  H  H62    . DA  A 1 10 ? -2.13696  -4.71167  5.83280   1.000 18.43926 ? 10  DA  C H62    1 
ATOM   319  H  H2     . DA  A 1 10 ? -5.74262  -2.46692  8.39438   1.000 16.90249 ? 10  DA  C H2     1 
ATOM   320  P  P      . DA  A 1 11 ? -11.44831 -8.47850  7.52225   1.000 27.96696 ? 11  DA  C P      1 
ATOM   321  O  OP1    . DA  A 1 11 ? -12.66356 -8.70405  8.34058   1.000 31.61718 ? 11  DA  C OP1    1 
ATOM   322  O  OP2    . DA  A 1 11 ? -11.10909 -9.29424  6.33637   1.000 27.73492 ? 11  DA  C OP2    1 
ATOM   323  O  "O5'"  . DA  A 1 11 ? -11.49470 -6.96962  7.03096   1.000 20.24322 ? 11  DA  C "O5'"  1 
ATOM   324  C  "C5'"  . DA  A 1 11 ? -11.55814 -5.97556  7.99583   1.000 17.55963 ? 11  DA  C "C5'"  1 
ATOM   325  C  "C4'"  . DA  A 1 11 ? -11.33174 -4.61351  7.38683   1.000 20.96750 ? 11  DA  C "C4'"  1 
ATOM   326  O  "O4'"  . DA  A 1 11 ? -9.93895  -4.47291  7.01543   1.000 21.76775 ? 11  DA  C "O4'"  1 
ATOM   327  C  "C3'"  . DA  A 1 11 ? -12.14021 -4.33440  6.11132   1.000 17.86555 ? 11  DA  C "C3'"  1 
ATOM   328  O  "O3'"  . DA  A 1 11 ? -12.71603 -3.04746  6.20405   1.000 21.13968 ? 11  DA  C "O3'"  1 
ATOM   329  C  "C2'"  . DA  A 1 11 ? -11.10219 -4.43056  5.00335   1.000 18.41510 ? 11  DA  C "C2'"  1 
ATOM   330  C  "C1'"  . DA  A 1 11 ? -9.86667  -3.92158  5.72851   1.000 16.89894 ? 11  DA  C "C1'"  1 
ATOM   331  N  N9     . DA  A 1 11 ? -8.60332  -4.29821  5.12798   1.000 15.02664 ? 11  DA  C N9     1 
ATOM   332  C  C8     . DA  A 1 11 ? -8.21564  -5.52642  4.68299   1.000 18.45727 ? 11  DA  C C8     1 
ATOM   333  N  N7     . DA  A 1 11 ? -6.99419  -5.54487  4.18398   1.000 15.30666 ? 11  DA  C N7     1 
ATOM   334  C  C5     . DA  A 1 11 ? -6.56409  -4.24193  4.34203   1.000 13.66670 ? 11  DA  C C5     1 
ATOM   335  C  C6     . DA  A 1 11 ? -5.37681  -3.59803  4.01471   1.000 13.61757 ? 11  DA  C C6     1 
ATOM   336  N  N6     . DA  A 1 11 ? -4.33504  -4.22454  3.45300   1.000 15.04058 ? 11  DA  C N6     1 
ATOM   337  N  N1     . DA  A 1 11 ? -5.28859  -2.27650  4.28372   1.000 10.89951 ? 11  DA  C N1     1 
ATOM   338  C  C2     . DA  A 1 11 ? -6.31648  -1.65630  4.83876   1.000 13.35480 ? 11  DA  C C2     1 
ATOM   339  N  N3     . DA  A 1 11 ? -7.49160  -2.16272  5.20239   1.000 12.12647 ? 11  DA  C N3     1 
ATOM   340  C  C4     . DA  A 1 11 ? -7.55020  -3.46309  4.91290   1.000 13.37569 ? 11  DA  C C4     1 
ATOM   341  H  "H5'"  . DA  A 1 11 ? -10.87936 -6.14070  8.66881   1.000 21.07156 ? 11  DA  C "H5'"  1 
ATOM   342  H  "H5''" . DA  A 1 11 ? -12.43174 -5.99529  8.41694   1.000 21.07156 ? 11  DA  C "H5''" 1 
ATOM   343  H  "H4'"  . DA  A 1 11 ? -11.54335 -3.93257  8.04444   1.000 25.16101 ? 11  DA  C "H4'"  1 
ATOM   344  H  "H3'"  . DA  A 1 11 ? -12.81874 -5.01323  5.97103   1.000 21.43866 ? 11  DA  C "H3'"  1 
ATOM   345  H  "H2'"  . DA  A 1 11 ? -10.98800 -5.34351  4.69615   1.000 22.09812 ? 11  DA  C "H2'"  1 
ATOM   346  H  "H2''" . DA  A 1 11 ? -11.33147 -3.86899  4.24640   1.000 22.09812 ? 11  DA  C "H2''" 1 
ATOM   347  H  "H1'"  . DA  A 1 11 ? -9.89736  -2.95304  5.77211   1.000 20.27873 ? 11  DA  C "H1'"  1 
ATOM   348  H  H8     . DA  A 1 11 ? -8.75968  -6.27941  4.72678   1.000 22.14873 ? 11  DA  C H8     1 
ATOM   349  H  H61    . DA  A 1 11 ? -3.61893  -3.78614  3.26702   1.000 18.04870 ? 11  DA  C H61    1 
ATOM   350  H  H62    . DA  A 1 11 ? -4.38213  -5.06528  3.27824   1.000 18.04870 ? 11  DA  C H62    1 
ATOM   351  H  H2     . DA  A 1 11 ? -6.20278  -0.74666  4.99539   1.000 16.02576 ? 11  DA  C H2     1 
ATOM   352  P  P      . DG  A 1 12 ? -13.58959 -2.42253  5.00024   1.000 19.71910 ? 12  DG  C P      1 
ATOM   353  O  OP1    . DG  A 1 12 ? -14.73170 -1.78852  5.69281   1.000 19.69212 ? 12  DG  C OP1    1 
ATOM   354  O  OP2    . DG  A 1 12 ? -13.79257 -3.39502  3.90689   1.000 20.49211 ? 12  DG  C OP2    1 
ATOM   355  O  "O5'"  . DG  A 1 12 ? -12.67723 -1.27939  4.40409   1.000 15.91247 ? 12  DG  C "O5'"  1 
ATOM   356  C  "C5'"  . DG  A 1 12 ? -12.32169 -0.16020  5.19559   1.000 17.53642 ? 12  DG  C "C5'"  1 
ATOM   357  C  "C4'"  . DG  A 1 12 ? -11.47236 0.79633   4.38461   1.000 18.06662 ? 12  DG  C "C4'"  1 
ATOM   358  O  "O4'"  . DG  A 1 12 ? -10.20427 0.16365   4.06293   1.000 16.94282 ? 12  DG  C "O4'"  1 
ATOM   359  C  "C3'"  . DG  A 1 12 ? -12.09522 1.21547   3.04398   1.000 14.22102 ? 12  DG  C "C3'"  1 
ATOM   360  O  "O3'"  . DG  A 1 12 ? -12.00988 2.60622   2.90753   1.000 15.32328 ? 12  DG  C "O3'"  1 
ATOM   361  C  "C2'"  . DG  A 1 12 ? -11.27335 0.46409   1.99533   1.000 13.41770 ? 12  DG  C "C2'"  1 
ATOM   362  C  "C1'"  . DG  A 1 12 ? -9.92085  0.33031   2.68396   1.000 13.51655 ? 12  DG  C "C1'"  1 
ATOM   363  N  N9     . DG  A 1 12 ? -9.12956  -0.80581  2.23327   1.000 13.01365 ? 12  DG  C N9     1 
ATOM   364  C  C8     . DG  A 1 12 ? -9.48521  -2.13011  2.23880   1.000 13.13099 ? 12  DG  C C8     1 
ATOM   365  N  N7     . DG  A 1 12 ? -8.56749  -2.92214  1.78031   1.000 13.96481 ? 12  DG  C N7     1 
ATOM   366  C  C5     . DG  A 1 12 ? -7.51278  -2.07439  1.46052   1.000 12.40031 ? 12  DG  C C5     1 
ATOM   367  C  C6     . DG  A 1 12 ? -6.23221  -2.36546  0.92417   1.000 12.75361 ? 12  DG  C C6     1 
ATOM   368  O  O6     . DG  A 1 12 ? -5.75789  -3.46520  0.61183   1.000 15.05113 ? 12  DG  C O6     1 
ATOM   369  N  N1     . DG  A 1 12 ? -5.48430  -1.20279  0.72392   1.000 12.36617 ? 12  DG  C N1     1 
ATOM   370  C  C2     . DG  A 1 12 ? -5.90455  0.06289   1.04321   1.000 11.50474 ? 12  DG  C C2     1 
ATOM   371  N  N2     . DG  A 1 12 ? -5.04743  1.05942   0.78467   1.000 11.52874 ? 12  DG  C N2     1 
ATOM   372  N  N3     . DG  A 1 12 ? -7.10696  0.34378   1.54275   1.000 11.45979 ? 12  DG  C N3     1 
ATOM   373  C  C4     . DG  A 1 12 ? -7.84188  -0.76823  1.73336   1.000 14.42582 ? 12  DG  C C4     1 
ATOM   374  H  "H5'"  . DG  A 1 12 ? -11.82170 -0.45848  5.97144   1.000 21.04371 ? 12  DG  C "H5'"  1 
ATOM   375  H  "H5''" . DG  A 1 12 ? -13.12550 0.29383   5.49333   1.000 21.04371 ? 12  DG  C "H5''" 1 
ATOM   376  H  "H4'"  . DG  A 1 12 ? -11.28907 1.59236   4.90772   1.000 21.67995 ? 12  DG  C "H4'"  1 
ATOM   377  H  "H3'"  . DG  A 1 12 ? -13.01595 0.91553   2.98746   1.000 17.06523 ? 12  DG  C "H3'"  1 
ATOM   378  H  "H2'"  . DG  A 1 12 ? -11.65835 -0.40446  1.79962   1.000 16.10124 ? 12  DG  C "H2'"  1 
ATOM   379  H  "H2''" . DG  A 1 12 ? -11.20244 0.97101   1.17138   1.000 16.10124 ? 12  DG  C "H2''" 1 
ATOM   380  H  "H1'"  . DG  A 1 12 ? -9.40734  1.14151   2.54549   1.000 16.21987 ? 12  DG  C "H1'"  1 
ATOM   381  H  H8     . DG  A 1 12 ? -10.31008 -2.43249  2.54385   1.000 15.75719 ? 12  DG  C H8     1 
ATOM   382  H  H1     . DG  A 1 12 ? -4.70289  -1.28691  0.37474   1.000 14.83940 ? 12  DG  C H1     1 
ATOM   383  H  H21    . DG  A 1 12 ? -5.27502  1.87384   0.94126   1.000 13.83449 ? 12  DG  C H21    1 
ATOM   384  H  H22    . DG  A 1 12 ? -4.26959  0.88475   0.46209   1.000 13.83449 ? 12  DG  C H22    1 
ATOM   385  P  P      . DT  A 1 13 ? -12.50025 3.34026   1.57471   1.000 16.87717 ? 13  DT  C P      1 
ATOM   386  O  OP1    . DT  A 1 13 ? -12.89788 4.69965   2.01763   1.000 18.22292 ? 13  DT  C OP1    1 
ATOM   387  O  OP2    . DT  A 1 13 ? -13.41124 2.45847   0.84272   1.000 17.30010 ? 13  DT  C OP2    1 
ATOM   388  O  "O5'"  . DT  A 1 13 ? -11.14624 3.45540   0.71663   1.000 18.59660 ? 13  DT  C "O5'"  1 
ATOM   389  C  "C5'"  . DT  A 1 13 ? -10.08184 4.23219   1.19710   1.000 17.75665 ? 13  DT  C "C5'"  1 
ATOM   390  C  "C4'"  . DT  A 1 13 ? -9.04671  4.45008   0.11536   1.000 16.44446 ? 13  DT  C "C4'"  1 
ATOM   391  O  "O4'"  . DT  A 1 13 ? -8.39396  3.19241   -0.16407  1.000 16.67147 ? 13  DT  C "O4'"  1 
ATOM   392  C  "C3'"  . DT  A 1 13 ? -9.61022  4.94373   -1.22785  1.000 16.25731 ? 13  DT  C "C3'"  1 
ATOM   393  O  "O3'"  . DT  A 1 13 ? -8.81152  6.03133   -1.71785  1.000 18.57701 ? 13  DT  C "O3'"  1 
ATOM   394  C  "C2'"  . DT  A 1 13 ? -9.54130  3.68735   -2.12209  1.000 20.09135 ? 13  DT  C "C2'"  1 
ATOM   395  C  "C1'"  . DT  A 1 13 ? -8.30256  3.02071   -1.57365  1.000 16.00153 ? 13  DT  C "C1'"  1 
ATOM   396  N  N1     . DT  A 1 13 ? -8.13937  1.60015   -1.80775  1.000 12.08461 ? 13  DT  C N1     1 
ATOM   397  C  C2     . DT  A 1 13 ? -6.90602  1.13867   -2.23010  1.000 12.19994 ? 13  DT  C C2     1 
ATOM   398  O  O2     . DT  A 1 13 ? -5.99023  1.87932   -2.55195  1.000 13.99786 ? 13  DT  C O2     1 
ATOM   399  N  N3     . DT  A 1 13 ? -6.81186  -0.21237  -2.35870  1.000 13.45029 ? 13  DT  C N3     1 
ATOM   400  C  C4     . DT  A 1 13 ? -7.76397  -1.14319  -2.04599  1.000 10.68806 ? 13  DT  C C4     1 
ATOM   401  O  O4     . DT  A 1 13 ? -7.56484  -2.34675  -2.16730  1.000 14.55844 ? 13  DT  C O4     1 
ATOM   402  C  C5     . DT  A 1 13 ? -9.02870  -0.60813  -1.57864  1.000 14.47019 ? 13  DT  C C5     1 
ATOM   403  C  C7     . DT  A 1 13 ? -10.14123 -1.53461  -1.21762  1.000 16.90794 ? 13  DT  C C7     1 
ATOM   404  C  C6     . DT  A 1 13 ? -9.14939  0.71586   -1.45441  1.000 15.45123 ? 13  DT  C C6     1 
ATOM   405  H  "H5'"  . DT  A 1 13 ? -9.66879  3.77924   1.94885   1.000 21.30798 ? 13  DT  C "H5'"  1 
ATOM   406  H  "H5''" . DT  A 1 13 ? -10.42082 5.09134   1.49352   1.000 21.30798 ? 13  DT  C "H5''" 1 
ATOM   407  H  "H4'"  . DT  A 1 13 ? -8.38369  5.08791   0.42272   1.000 19.73335 ? 13  DT  C "H4'"  1 
ATOM   408  H  "H3'"  . DT  A 1 13 ? -10.53581 5.21973   -1.13843  1.000 19.50877 ? 13  DT  C "H3'"  1 
ATOM   409  H  "H2'"  . DT  A 1 13 ? -10.32683 3.12802   -2.01729  1.000 24.10962 ? 13  DT  C "H2'"  1 
ATOM   410  H  "H2''" . DT  A 1 13 ? -9.44054  3.91800   -3.05887  1.000 24.10962 ? 13  DT  C "H2''" 1 
ATOM   411  H  "H1'"  . DT  A 1 13 ? -7.53840  3.46808   -1.96966  1.000 19.20183 ? 13  DT  C "H1'"  1 
ATOM   412  H  H3     . DT  A 1 13 ? -6.07033  -0.51520  -2.67180  1.000 16.14035 ? 13  DT  C H3     1 
ATOM   413  H  H71    . DT  A 1 13 ? -10.49508 -1.28059  -0.35092  1.000 20.28953 ? 13  DT  C H71    1 
ATOM   414  H  H72    . DT  A 1 13 ? -10.83678 -1.47027  -1.89066  1.000 20.28953 ? 13  DT  C H72    1 
ATOM   415  H  H73    . DT  A 1 13 ? -9.79823  -2.44125  -1.18205  1.000 20.28953 ? 13  DT  C H73    1 
ATOM   416  H  H6     . DT  A 1 13 ? -9.94440  1.06043   -1.11659  1.000 18.54148 ? 13  DT  C H6     1 
ATOM   417  P  P      . DG  A 1 14 ? -9.29859  6.92668   -2.95355  1.000 23.16498 ? 14  DG  C P      1 
ATOM   418  O  OP1    . DG  A 1 14 ? -9.02467  8.34011   -2.57952  1.000 27.08128 ? 14  DG  C OP1    1 
ATOM   419  O  OP2    . DG  A 1 14 ? -10.65776 6.52533   -3.31211  1.000 20.34255 ? 14  DG  C OP2    1 
ATOM   420  O  "O5'"  . DG  A 1 14 ? -8.29449  6.55424   -4.13354  1.000 25.94207 ? 14  DG  C "O5'"  1 
ATOM   421  C  "C5'"  . DG  A 1 14 ? -7.20713  5.77619   -3.86634  1.000 30.93376 ? 14  DG  C "C5'"  1 
ATOM   422  C  "C4'"  . DG  A 1 14 ? -6.29273  5.62033   -5.07371  1.000 25.84554 ? 14  DG  C "C4'"  1 
ATOM   423  O  "O4'"  . DG  A 1 14 ? -5.90896  4.22838   -5.17925  1.000 26.65909 ? 14  DG  C "O4'"  1 
ATOM   424  C  "C3'"  . DG  A 1 14 ? -6.84354  6.00818   -6.44112  1.000 21.56927 ? 14  DG  C "C3'"  1 
ATOM   425  O  "O3'"  . DG  A 1 14 ? -5.81620  6.72092   -7.13668  1.000 23.59924 ? 14  DG  C "O3'"  1 
ATOM   426  C  "C2'"  . DG  A 1 14 ? -7.19388  4.65045   -7.08841  1.000 17.08307 ? 14  DG  C "C2'"  1 
ATOM   427  C  "C1'"  . DG  A 1 14 ? -6.16348  3.72333   -6.48133  1.000 19.74553 ? 14  DG  C "C1'"  1 
ATOM   428  N  N9     . DG  A 1 14 ? -6.54637  2.31868   -6.28701  1.000 17.27975 ? 14  DG  C N9     1 
ATOM   429  C  C8     . DG  A 1 14 ? -5.70225  1.25992   -6.37434  1.000 16.59186 ? 14  DG  C C8     1 
ATOM   430  N  N7     . DG  A 1 14 ? -6.23336  0.12291   -6.07139  1.000 14.32665 ? 14  DG  C N7     1 
ATOM   431  C  C5     . DG  A 1 14 ? -7.55280  0.43994   -5.74639  1.000 15.79470 ? 14  DG  C C5     1 
ATOM   432  C  C6     . DG  A 1 14 ? -8.59920  -0.40055  -5.34376  1.000 13.61299 ? 14  DG  C C6     1 
ATOM   433  O  O6     . DG  A 1 14 ? -8.57510  -1.62213  -5.18760  1.000 14.92931 ? 14  DG  C O6     1 
ATOM   434  N  N1     . DG  A 1 14 ? -9.77096  0.31199   -5.10286  1.000 16.19900 ? 14  DG  C N1     1 
ATOM   435  C  C2     . DG  A 1 14 ? -9.90334  1.67555   -5.23555  1.000 13.74546 ? 14  DG  C C2     1 
ATOM   436  N  N2     . DG  A 1 14 ? -11.13244 2.17968   -4.97757  1.000 18.04303 ? 14  DG  C N2     1 
ATOM   437  N  N3     . DG  A 1 14 ? -8.90799  2.49470   -5.60349  1.000 17.48649 ? 14  DG  C N3     1 
ATOM   438  C  C4     . DG  A 1 14 ? -7.76291  1.80277   -5.84745  1.000 15.04786 ? 14  DG  C C4     1 
ATOM   439  H  "H5'"  . DG  A 1 14 ? -7.51116  4.89802   -3.58837  1.000 37.12051 ? 14  DG  C "H5'"  1 
ATOM   440  H  "H5''" . DG  A 1 14 ? -6.70356  6.17988   -3.14222  1.000 37.12051 ? 14  DG  C "H5''" 1 
ATOM   441  H  "H4'"  . DG  A 1 14 ? -5.51194  6.17752   -4.92943  1.000 31.01465 ? 14  DG  C "H4'"  1 
ATOM   442  H  "H3'"  . DG  A 1 14 ? -7.65788  6.53122   -6.37650  1.000 25.88313 ? 14  DG  C "H3'"  1 
ATOM   443  H  "H2'"  . DG  A 1 14 ? -8.09518  4.37336   -6.86084  1.000 20.49968 ? 14  DG  C "H2'"  1 
ATOM   444  H  "H2''" . DG  A 1 14 ? -7.10929  4.68780   -8.05399  1.000 20.49968 ? 14  DG  C "H2''" 1 
ATOM   445  H  "H1'"  . DG  A 1 14 ? -5.39054  3.75574   -7.06649  1.000 23.69464 ? 14  DG  C "H1'"  1 
ATOM   446  H  H8     . DG  A 1 14 ? -4.81276  1.34637   -6.63169  1.000 19.91023 ? 14  DG  C H8     1 
ATOM   447  H  H1     . DG  A 1 14 ? -10.46317 -0.13280  -4.85265  1.000 19.43880 ? 14  DG  C H1     1 
ATOM   448  H  H21    . DG  A 1 14 ? -11.27439 3.02481   -5.04973  1.000 21.65164 ? 14  DG  C H21    1 
ATOM   449  H  H22    . DG  A 1 14 ? -11.77157 1.65492   -4.74147  1.000 21.65164 ? 14  DG  C H22    1 
ATOM   450  P  P      . DG  A 1 15 ? -6.04864  7.41562   -8.56258  1.000 25.89574 ? 15  DG  C P      1 
ATOM   451  O  OP1    . DG  A 1 15 ? -4.92961  8.39282   -8.67840  1.000 24.57701 ? 15  DG  C OP1    1 
ATOM   452  O  OP2    . DG  A 1 15 ? -7.46353  7.72893   -8.78568  1.000 19.91368 ? 15  DG  C OP2    1 
ATOM   453  O  "O5'"  . DG  A 1 15 ? -5.71665  6.26395   -9.60359  1.000 20.46071 ? 15  DG  C "O5'"  1 
ATOM   454  C  "C5'"  . DG  A 1 15 ? -4.42531  5.73232   -9.63262  1.000 18.97460 ? 15  DG  C "C5'"  1 
ATOM   455  C  "C4'"  . DG  A 1 15 ? -4.39813  4.53579   -10.53110 1.000 20.69757 ? 15  DG  C "C4'"  1 
ATOM   456  O  "O4'"  . DG  A 1 15 ? -5.11374  3.45650   -9.88273  1.000 20.00886 ? 15  DG  C "O4'"  1 
ATOM   457  C  "C3'"  . DG  A 1 15 ? -5.08032  4.73515   -11.88111 1.000 19.68756 ? 15  DG  C "C3'"  1 
ATOM   458  O  "O3'"  . DG  A 1 15 ? -4.23946  4.26316   -12.91143 1.000 21.01694 ? 15  DG  C "O3'"  1 
ATOM   459  C  "C2'"  . DG  A 1 15 ? -6.35693  3.89861   -11.75907 1.000 17.27687 ? 15  DG  C "C2'"  1 
ATOM   460  C  "C1'"  . DG  A 1 15 ? -5.86795  2.80222   -10.84917 1.000 15.97639 ? 15  DG  C "C1'"  1 
ATOM   461  N  N9     . DG  A 1 15 ? -6.90426  2.02933   -10.19343 1.000 11.83972 ? 15  DG  C N9     1 
ATOM   462  C  C8     . DG  A 1 15 ? -8.11907  2.46309   -9.73484  1.000 13.73705 ? 15  DG  C C8     1 
ATOM   463  N  N7     . DG  A 1 15 ? -8.83251  1.51056   -9.19860  1.000 11.29581 ? 15  DG  C N7     1 
ATOM   464  C  C5     . DG  A 1 15 ? -8.02347  0.38056   -9.31072  1.000 12.33417 ? 15  DG  C C5     1 
ATOM   465  C  C6     . DG  A 1 15 ? -8.24143  -0.95993  -8.90959  1.000 14.06416 ? 15  DG  C C6     1 
ATOM   466  O  O6     . DG  A 1 15 ? -9.23994  -1.44647  -8.37838  1.000 14.64328 ? 15  DG  C O6     1 
ATOM   467  N  N1     . DG  A 1 15 ? -7.14570  -1.77731  -9.20846  1.000 12.58111 ? 15  DG  C N1     1 
ATOM   468  C  C2     . DG  A 1 15 ? -6.00878  -1.35419  -9.82765  1.000 14.75809 ? 15  DG  C C2     1 
ATOM   469  N  N2     . DG  A 1 15 ? -5.06990  -2.27862  -10.04285 1.000 15.33865 ? 15  DG  C N2     1 
ATOM   470  N  N3     . DG  A 1 15 ? -5.79603  -0.10183  -10.20109 1.000 14.99247 ? 15  DG  C N3     1 
ATOM   471  C  C4     . DG  A 1 15 ? -6.83110  0.69908   -9.90564  1.000 14.00142 ? 15  DG  C C4     1 
ATOM   472  H  "H5'"  . DG  A 1 15 ? -4.16060  5.47209   -8.73645  1.000 22.76952 ? 15  DG  C "H5'"  1 
ATOM   473  H  "H5''" . DG  A 1 15 ? -3.80562  6.40134   -9.96322  1.000 22.76952 ? 15  DG  C "H5''" 1 
ATOM   474  H  "H4'"  . DG  A 1 15 ? -3.48025  4.26333   -10.68653 1.000 24.83709 ? 15  DG  C "H4'"  1 
ATOM   475  H  "H3'"  . DG  A 1 15 ? -5.30820  5.66853   -12.01448 1.000 23.62507 ? 15  DG  C "H3'"  1 
ATOM   476  H  "H2'"  . DG  A 1 15 ? -7.08311  4.40292   -11.36002 1.000 20.73224 ? 15  DG  C "H2'"  1 
ATOM   477  H  "H2''" . DG  A 1 15 ? -6.64677  3.55351   -12.61802 1.000 20.73224 ? 15  DG  C "H2''" 1 
ATOM   478  H  "H1'"  . DG  A 1 15 ? -5.32092  2.18153   -11.35552 1.000 19.17167 ? 15  DG  C "H1'"  1 
ATOM   479  H  H8     . DG  A 1 15 ? -8.40635  3.34529   -9.79878  1.000 16.48446 ? 15  DG  C H8     1 
ATOM   480  H  H1     . DG  A 1 15 ? -7.19360  -2.60642  -8.98512  1.000 15.09733 ? 15  DG  C H1     1 
ATOM   481  H  H21    . DG  A 1 15 ? -4.33008  -2.05978  -10.42282 1.000 18.40638 ? 15  DG  C H21    1 
ATOM   482  H  H22    . DG  A 1 15 ? -5.20492  -3.09294  -9.80151  1.000 18.40638 ? 15  DG  C H22    1 
ATOM   483  P  P      . DG  A 1 16 ? -4.50315  4.70165   -14.42708 1.000 22.29285 ? 16  DG  C P      1 
ATOM   484  O  OP1    . DG  A 1 16 ? -3.23746  4.41375   -15.12096 1.000 24.04613 ? 16  DG  C OP1    1 
ATOM   485  O  OP2    . DG  A 1 16 ? -5.10429  6.04572   -14.47670 1.000 26.41992 ? 16  DG  C OP2    1 
ATOM   486  O  "O5'"  . DG  A 1 16 ? -5.68151  3.74203   -14.93722 1.000 25.88588 ? 16  DG  C "O5'"  1 
ATOM   487  C  "C5'"  . DG  A 1 16 ? -5.40314  2.58771   -15.70757 1.000 27.74221 ? 16  DG  C "C5'"  1 
ATOM   488  C  "C4'"  . DG  A 1 16 ? -4.78138  1.48292   -14.87334 1.000 21.73422 ? 16  DG  C "C4'"  1 
ATOM   489  O  "O4'"  . DG  A 1 16 ? -5.63908  1.17767   -13.72690 1.000 19.81196 ? 16  DG  C "O4'"  1 
ATOM   490  C  "C3'"  . DG  A 1 16 ? -4.62262  0.15779   -15.61859 1.000 20.60510 ? 16  DG  C "C3'"  1 
ATOM   491  O  "O3'"  . DG  A 1 16 ? -3.48582  -0.53933  -15.18147 1.000 25.68679 ? 16  DG  C "O3'"  1 
ATOM   492  C  "C2'"  . DG  A 1 16 ? -5.90107  -0.57373  -15.24434 1.000 20.22268 ? 16  DG  C "C2'"  1 
ATOM   493  C  "C1'"  . DG  A 1 16 ? -6.03313  -0.17922  -13.78599 1.000 20.80078 ? 16  DG  C "C1'"  1 
ATOM   494  N  N9     . DG  A 1 16 ? -7.37846  -0.28569  -13.23334 1.000 15.09405 ? 16  DG  C N9     1 
ATOM   495  C  C8     . DG  A 1 16 ? -8.28669  0.72956   -13.09731 1.000 14.28563 ? 16  DG  C C8     1 
ATOM   496  N  N7     . DG  A 1 16 ? -9.40576  0.35489   -12.54413 1.000 15.85043 ? 16  DG  C N7     1 
ATOM   497  C  C5     . DG  A 1 16 ? -9.21313  -1.00232  -12.28469 1.000 15.20136 ? 16  DG  C C5     1 
ATOM   498  C  C6     . DG  A 1 16 ? -10.06847 -1.94366  -11.67498 1.000 11.40011 ? 16  DG  C C6     1 
ATOM   499  O  O6     . DG  A 1 16 ? -11.22390 -1.77599  -11.26825 1.000 12.38531 ? 16  DG  C O6     1 
ATOM   500  N  N1     . DG  A 1 16 ? -9.48101  -3.20411  -11.60635 1.000 12.52113 ? 16  DG  C N1     1 
ATOM   501  C  C2     . DG  A 1 16 ? -8.23030  -3.50881  -12.06974 1.000 13.88591 ? 16  DG  C C2     1 
ATOM   502  N  N2     . DG  A 1 16 ? -7.83145  -4.79222  -11.93626 1.000 16.64584 ? 16  DG  C N2     1 
ATOM   503  N  N3     . DG  A 1 16 ? -7.41943  -2.62538  -12.62963 1.000 13.76075 ? 16  DG  C N3     1 
ATOM   504  C  C4     . DG  A 1 16 ? -7.96916  -1.40319  -12.70043 1.000 13.93155 ? 16  DG  C C4     1 
ATOM   505  H  "H5'"  . DG  A 1 16 ? -4.79104  2.82566   -16.42144 1.000 33.29065 ? 16  DG  C "H5'"  1 
ATOM   506  H  "H5''" . DG  A 1 16 ? -6.22992  2.26154   -16.09609 1.000 33.29065 ? 16  DG  C "H5''" 1 
ATOM   507  H  "H4'"  . DG  A 1 16 ? -3.92066  1.78141   -14.54023 1.000 26.08107 ? 16  DG  C "H4'"  1 
ATOM   508  H  "H3'"  . DG  A 1 16 ? -4.56964  0.31558   -16.57420 1.000 24.72612 ? 16  DG  C "H3'"  1 
ATOM   509  H  "HO3'" . DG  A 1 16 ? -3.56958  -1.28647  -14.80682 1.000 30.82414 ? 16  DG  C "HO3'" 1 
ATOM   510  H  "H2'"  . DG  A 1 16 ? -6.65718  -0.26805  -15.76946 1.000 24.26721 ? 16  DG  C "H2'"  1 
ATOM   511  H  "H2''" . DG  A 1 16 ? -5.81035  -1.53364  -15.35041 1.000 24.26721 ? 16  DG  C "H2''" 1 
ATOM   512  H  "H1'"  . DG  A 1 16 ? -5.44217  -0.73583  -13.25510 1.000 24.96094 ? 16  DG  C "H1'"  1 
ATOM   513  H  H8     . DG  A 1 16 ? -8.12117  1.60221   -13.37296 1.000 17.14275 ? 16  DG  C H8     1 
ATOM   514  H  H1     . DG  A 1 16 ? -9.93782  -3.83757  -11.24628 1.000 15.02535 ? 16  DG  C H1     1 
ATOM   515  H  H21    . DG  A 1 16 ? -7.05383  -5.03200  -12.21448 1.000 19.97501 ? 16  DG  C H21    1 
ATOM   516  H  H22    . DG  A 1 16 ? -8.35510  -5.36968  -11.57303 1.000 19.97501 ? 16  DG  C H22    1 
ATOM   517  O  "O5'"  . DT  B 2 1  ? -17.43427 -8.83580  -10.32695 1.000 33.10630 ? 17  DT  D "O5'"  1 
ATOM   518  C  "C5'"  . DT  B 2 1  ? -17.34957 -9.56088  -11.56731 1.000 29.78098 ? 17  DT  D "C5'"  1 
ATOM   519  C  "C4'"  . DT  B 2 1  ? -15.95848 -10.16742 -11.78571 1.000 22.03082 ? 17  DT  D "C4'"  1 
ATOM   520  O  "O4'"  . DT  B 2 1  ? -15.07400 -9.21954  -12.43596 1.000 22.27487 ? 17  DT  D "O4'"  1 
ATOM   521  C  "C3'"  . DT  B 2 1  ? -15.20106 -10.60805 -10.54899 1.000 18.30288 ? 17  DT  D "C3'"  1 
ATOM   522  O  "O3'"  . DT  B 2 1  ? -14.37266 -11.71224 -10.91343 1.000 18.65371 ? 17  DT  D "O3'"  1 
ATOM   523  C  "C2'"  . DT  B 2 1  ? -14.38913 -9.35545  -10.17232 1.000 16.71447 ? 17  DT  D "C2'"  1 
ATOM   524  C  "C1'"  . DT  B 2 1  ? -14.06318 -8.75675  -11.54370 1.000 17.51279 ? 17  DT  D "C1'"  1 
ATOM   525  N  N1     . DT  B 2 1  ? -14.10391 -7.27598  -11.64840 1.000 15.85455 ? 17  DT  D N1     1 
ATOM   526  C  C2     . DT  B 2 1  ? -13.15244 -6.61945  -12.39049 1.000 15.17317 ? 17  DT  D C2     1 
ATOM   527  O  O2     . DT  B 2 1  ? -12.17545 -7.17458  -12.89002 1.000 16.29389 ? 17  DT  D O2     1 
ATOM   528  N  N3     . DT  B 2 1  ? -13.34631 -5.26917  -12.49672 1.000 13.88510 ? 17  DT  D N3     1 
ATOM   529  C  C4     . DT  B 2 1  ? -14.38268 -4.53636  -11.97245 1.000 15.39991 ? 17  DT  D C4     1 
ATOM   530  O  O4     . DT  B 2 1  ? -14.46221 -3.32221  -12.12239 1.000 15.60077 ? 17  DT  D O4     1 
ATOM   531  C  C5     . DT  B 2 1  ? -15.35985 -5.28814  -11.24019 1.000 13.59817 ? 17  DT  D C5     1 
ATOM   532  C  C7     . DT  B 2 1  ? -16.53945 -4.59811  -10.62217 1.000 19.74940 ? 17  DT  D C7     1 
ATOM   533  C  C6     . DT  B 2 1  ? -15.18997 -6.60863  -11.12976 1.000 19.12151 ? 17  DT  D C6     1 
ATOM   534  H  "H5'"  . DT  B 2 1  ? -17.54785 -8.95632  -12.29949 1.000 35.73717 ? 17  DT  D "H5'"  1 
ATOM   535  H  "H5''" . DT  B 2 1  ? -18.00654 -10.27449 -11.56025 1.000 35.73717 ? 17  DT  D "H5''" 1 
ATOM   536  H  "H4'"  . DT  B 2 1  ? -16.08315 -10.93531 -12.36511 1.000 26.43699 ? 17  DT  D "H4'"  1 
ATOM   537  H  "H3'"  . DT  B 2 1  ? -15.79397 -10.83232 -9.81478  1.000 21.96345 ? 17  DT  D "H3'"  1 
ATOM   538  H  "H2'"  . DT  B 2 1  ? -14.91398 -8.74226  -9.63433  1.000 20.05737 ? 17  DT  D "H2'"  1 
ATOM   539  H  "H2''" . DT  B 2 1  ? -13.58214 -9.58951  -9.68767  1.000 20.05737 ? 17  DT  D "H2''" 1 
ATOM   540  H  "H1'"  . DT  B 2 1  ? -13.17760 -9.07572  -11.77802 1.000 21.01535 ? 17  DT  D "H1'"  1 
ATOM   541  H  H3     . DT  B 2 1  ? -12.75404 -4.83123  -12.94060 1.000 16.66212 ? 17  DT  D H3     1 
ATOM   542  H  H71    . DT  B 2 1  ? -16.49329 -3.65076  -10.82539 1.000 23.69928 ? 17  DT  D H71    1 
ATOM   543  H  H72    . DT  B 2 1  ? -17.35412 -4.97578  -10.98902 1.000 23.69928 ? 17  DT  D H72    1 
ATOM   544  H  H73    . DT  B 2 1  ? -16.51607 -4.73191  -9.66173  1.000 23.69928 ? 17  DT  D H73    1 
ATOM   545  H  H6     . DT  B 2 1  ? -15.83789 -7.10141  -10.68001 1.000 22.94581 ? 17  DT  D H6     1 
ATOM   546  H  "HO5'" . DT  B 2 1  ? -17.98213 -8.20386  -10.24605 1.000 39.72756 ? 17  DT  D "HO5'" 1 
ATOM   547  P  P      . DC  B 2 2  ? -13.69298 -12.66363 -9.81377  1.000 17.23119 ? 18  DC  D P      1 
ATOM   548  O  OP1    . DC  B 2 2  ? -13.38432 -13.90103 -10.54953 1.000 16.50576 ? 18  DC  D OP1    1 
ATOM   549  O  OP2    . DC  B 2 2  ? -14.44764 -12.61963 -8.55118  1.000 17.98246 ? 18  DC  D OP2    1 
ATOM   550  O  "O5'"  . DC  B 2 2  ? -12.30440 -11.94549 -9.51191  1.000 15.77620 ? 18  DC  D "O5'"  1 
ATOM   551  C  "C5'"  . DC  B 2 2  ? -11.36305 -11.83084 -10.51412 1.000 18.63553 ? 18  DC  D "C5'"  1 
ATOM   552  C  "C4'"  . DC  B 2 2  ? -10.31405 -10.82291 -10.10120 1.000 15.78235 ? 18  DC  D "C4'"  1 
ATOM   553  O  "O4'"  . DC  B 2 2  ? -10.80992 -9.48252  -10.38158 1.000 15.52461 ? 18  DC  D "O4'"  1 
ATOM   554  C  "C3'"  . DC  B 2 2  ? -9.95679  -10.81458 -8.58328  1.000 16.79940 ? 18  DC  D "C3'"  1 
ATOM   555  O  "O3'"  . DC  B 2 2  ? -8.56413  -10.70184 -8.39999  1.000 19.03066 ? 18  DC  D "O3'"  1 
ATOM   556  C  "C2'"  . DC  B 2 2  ? -10.63495 -9.54457  -8.10212  1.000 19.19014 ? 18  DC  D "C2'"  1 
ATOM   557  C  "C1'"  . DC  B 2 2  ? -10.37501 -8.68936  -9.32256  1.000 16.12506 ? 18  DC  D "C1'"  1 
ATOM   558  N  N1     . DC  B 2 2  ? -11.02015 -7.38700  -9.35476  1.000 14.96891 ? 18  DC  D N1     1 
ATOM   559  C  C2     . DC  B 2 2  ? -10.48495 -6.43121  -10.18905 1.000 13.99509 ? 18  DC  D C2     1 
ATOM   560  O  O2     . DC  B 2 2  ? -9.51034  -6.74225  -10.89546 1.000 13.40367 ? 18  DC  D O2     1 
ATOM   561  N  N3     . DC  B 2 2  ? -11.02182 -5.19208  -10.19696 1.000 14.74761 ? 18  DC  D N3     1 
ATOM   562  C  C4     . DC  B 2 2  ? -12.06670 -4.91600  -9.41258  1.000 14.76750 ? 18  DC  D C4     1 
ATOM   563  N  N4     . DC  B 2 2  ? -12.56366 -3.67846  -9.43948  1.000 14.20987 ? 18  DC  D N4     1 
ATOM   564  C  C5     . DC  B 2 2  ? -12.62592 -5.89374  -8.54302  1.000 16.03181 ? 18  DC  D C5     1 
ATOM   565  C  C6     . DC  B 2 2  ? -12.06564 -7.10338  -8.53788  1.000 16.60378 ? 18  DC  D C6     1 
ATOM   566  H  "H5'"  . DC  B 2 2  ? -11.79265 -11.53738 -11.33279 1.000 22.36264 ? 18  DC  D "H5'"  1 
ATOM   567  H  "H5''" . DC  B 2 2  ? -10.94457 -12.69223 -10.66832 1.000 22.36264 ? 18  DC  D "H5''" 1 
ATOM   568  H  "H4'"  . DC  B 2 2  ? -9.50478  -10.98547 -10.61066 1.000 18.93881 ? 18  DC  D "H4'"  1 
ATOM   569  H  "H3'"  . DC  B 2 2  ? -10.30989 -11.61062 -8.15602  1.000 20.15928 ? 18  DC  D "H3'"  1 
ATOM   570  H  "H2'"  . DC  B 2 2  ? -11.58198 -9.67204  -7.93544  1.000 23.02817 ? 18  DC  D "H2'"  1 
ATOM   571  H  "H2''" . DC  B 2 2  ? -10.21942 -9.18399  -7.30323  1.000 23.02817 ? 18  DC  D "H2''" 1 
ATOM   572  H  "H1'"  . DC  B 2 2  ? -9.42641  -8.50180  -9.39923  1.000 19.35007 ? 18  DC  D "H1'"  1 
ATOM   573  H  H41    . DC  B 2 2  ? -13.23633 -3.47434  -8.94405  1.000 17.05184 ? 18  DC  D H41    1 
ATOM   574  H  H42    . DC  B 2 2  ? -12.21140 -3.08468  -9.95226  1.000 17.05184 ? 18  DC  D H42    1 
ATOM   575  H  H5     . DC  B 2 2  ? -13.35416 -5.69650  -7.99927  1.000 19.23817 ? 18  DC  D H5     1 
ATOM   576  H  H6     . DC  B 2 2  ? -12.39514 -7.76026  -7.96792  1.000 19.92454 ? 18  DC  D H6     1 
ATOM   577  P  P      . DC  B 2 3  ? -7.71572  -11.75254 -7.53746  1.000 19.87157 ? 19  DC  D P      1 
ATOM   578  O  OP1    . DC  B 2 3  ? -7.88599  -13.04505 -8.24567  1.000 18.56388 ? 19  DC  D OP1    1 
ATOM   579  O  OP2    . DC  B 2 3  ? -7.98386  -11.59104 -6.11543  1.000 23.58950 ? 19  DC  D OP2    1 
ATOM   580  O  "O5'"  . DC  B 2 3  ? -6.24174  -11.19484 -7.80005  1.000 19.92371 ? 19  DC  D "O5'"  1 
ATOM   581  C  "C5'"  . DC  B 2 3  ? -5.72721  -11.19529 -9.11261  1.000 24.38650 ? 19  DC  D "C5'"  1 
ATOM   582  C  "C4'"  . DC  B 2 3  ? -5.05406  -9.87303  -9.43902  1.000 20.42663 ? 19  DC  D "C4'"  1 
ATOM   583  O  "O4'"  . DC  B 2 3  ? -6.05781  -8.83028  -9.50111  1.000 17.71060 ? 19  DC  D "O4'"  1 
ATOM   584  C  "C3'"  . DC  B 2 3  ? -4.00111  -9.39164  -8.42373  1.000 20.19139 ? 19  DC  D "C3'"  1 
ATOM   585  O  "O3'"  . DC  B 2 3  ? -2.75997  -9.20076  -9.06113  1.000 22.37263 ? 19  DC  D "O3'"  1 
ATOM   586  C  "C2'"  . DC  B 2 3  ? -4.56382  -8.08961  -7.88800  1.000 20.18862 ? 19  DC  D "C2'"  1 
ATOM   587  C  "C1'"  . DC  B 2 3  ? -5.48976  -7.65348  -9.00338  1.000 17.54866 ? 19  DC  D "C1'"  1 
ATOM   588  N  N1     . DC  B 2 3  ? -6.53647  -6.76073  -8.55981  1.000 16.20912 ? 19  DC  D N1     1 
ATOM   589  C  C2     . DC  B 2 3  ? -6.48314  -5.42777  -8.93330  1.000 13.16986 ? 19  DC  D C2     1 
ATOM   590  O  O2     . DC  B 2 3  ? -5.56506  -5.05662  -9.67214  1.000 14.52411 ? 19  DC  D O2     1 
ATOM   591  N  N3     . DC  B 2 3  ? -7.45209  -4.58900  -8.50189  1.000 13.44226 ? 19  DC  D N3     1 
ATOM   592  C  C4     . DC  B 2 3  ? -8.41893  -5.04533  -7.70180  1.000 14.36938 ? 19  DC  D C4     1 
ATOM   593  N  N4     . DC  B 2 3  ? -9.35184  -4.18211  -7.27446  1.000 14.55226 ? 19  DC  D N4     1 
ATOM   594  C  C5     . DC  B 2 3  ? -8.46971  -6.40708  -7.29711  1.000 14.60876 ? 19  DC  D C5     1 
ATOM   595  C  C6     . DC  B 2 3  ? -7.51422  -7.21227  -7.73014  1.000 13.66479 ? 19  DC  D C6     1 
ATOM   596  H  "H5'"  . DC  B 2 3  ? -6.45251  -11.34629 -9.73874  1.000 29.26380 ? 19  DC  D "H5'"  1 
ATOM   597  H  "H5''" . DC  B 2 3  ? -5.07979  -11.91224 -9.20044  1.000 29.26380 ? 19  DC  D "H5''" 1 
ATOM   598  H  "H4'"  . DC  B 2 3  ? -4.62254  -9.94638  -10.30465 1.000 24.51196 ? 19  DC  D "H4'"  1 
ATOM   599  H  "H3'"  . DC  B 2 3  ? -3.92920  -10.03573 -7.70201  1.000 24.22966 ? 19  DC  D "H3'"  1 
ATOM   600  H  "H2'"  . DC  B 2 3  ? -5.04955  -8.22901  -7.06003  1.000 24.22635 ? 19  DC  D "H2'"  1 
ATOM   601  H  "H2''" . DC  B 2 3  ? -3.86195  -7.43745  -7.73643  1.000 24.22635 ? 19  DC  D "H2''" 1 
ATOM   602  H  "H1'"  . DC  B 2 3  ? -4.98941  -7.21749  -9.71081  1.000 21.05839 ? 19  DC  D "H1'"  1 
ATOM   603  H  H41    . DC  B 2 3  ? -9.98421  -4.45305  -6.75842  1.000 17.46271 ? 19  DC  D H41    1 
ATOM   604  H  H42    . DC  B 2 3  ? -9.31778  -3.35755  -7.51642  1.000 17.46271 ? 19  DC  D H42    1 
ATOM   605  H  H5     . DC  B 2 3  ? -9.15095  -6.72070  -6.74715  1.000 17.53051 ? 19  DC  D H5     1 
ATOM   606  H  H6     . DC  B 2 3  ? -7.51106  -8.10290  -7.46244  1.000 16.39775 ? 19  DC  D H6     1 
ATOM   607  P  P      . DC  B 2 4  ? -1.47322  -8.61507  -8.27063  1.000 25.03015 ? 20  DC  D P      1 
ATOM   608  O  OP1    . DC  B 2 4  ? -0.34854  -9.12986  -9.07710  1.000 28.53978 ? 20  DC  D OP1    1 
ATOM   609  O  OP2    . DC  B 2 4  ? -1.59079  -8.77485  -6.81501  1.000 24.51031 ? 20  DC  D OP2    1 
ATOM   610  O  "O5'"  . DC  B 2 4  ? -1.53093  -7.03678  -8.49986  1.000 21.90923 ? 20  DC  D "O5'"  1 
ATOM   611  C  "C5'"  . DC  B 2 4  ? -1.49918  -6.50831  -9.79390  1.000 25.94432 ? 20  DC  D "C5'"  1 
ATOM   612  C  "C4'"  . DC  B 2 4  ? -1.15967  -5.02906  -9.75506  1.000 17.53766 ? 20  DC  D "C4'"  1 
ATOM   613  O  "O4'"  . DC  B 2 4  ? -2.29172  -4.26789  -9.26540  1.000 18.84956 ? 20  DC  D "O4'"  1 
ATOM   614  C  "C3'"  . DC  B 2 4  ? -0.00000  -4.67281  -8.84350  1.000 14.48094 ? 20  DC  D "C3'"  1 
ATOM   615  O  "O3'"  . DC  B 2 4  ? 0.78668   -3.70932  -9.49246  1.000 15.94561 ? 20  DC  D "O3'"  1 
ATOM   616  C  "C2'"  . DC  B 2 4  ? -0.68938  -4.15274  -7.57901  1.000 14.03132 ? 20  DC  D "C2'"  1 
ATOM   617  C  "C1'"  . DC  B 2 4  ? -1.93142  -3.50335  -8.13303  1.000 19.69201 ? 20  DC  D "C1'"  1 
ATOM   618  N  N1     . DC  B 2 4  ? -3.12981  -3.50611  -7.25675  1.000 13.50993 ? 20  DC  D N1     1 
ATOM   619  C  C2     . DC  B 2 4  ? -3.84113  -2.31920  -7.06652  1.000 13.83557 ? 20  DC  D C2     1 
ATOM   620  O  O2     . DC  B 2 4  ? -3.39691  -1.26071  -7.52183  1.000 14.58963 ? 20  DC  D O2     1 
ATOM   621  N  N3     . DC  B 2 4  ? -4.99050  -2.35386  -6.35710  1.000 15.50116 ? 20  DC  D N3     1 
ATOM   622  C  C4     . DC  B 2 4  ? -5.43282  -3.51273  -5.86314  1.000 17.01313 ? 20  DC  D C4     1 
ATOM   623  N  N4     . DC  B 2 4  ? -6.59446  -3.50450  -5.17070  1.000 13.89731 ? 20  DC  D N4     1 
ATOM   624  C  C5     . DC  B 2 4  ? -4.73543  -4.73030  -6.07382  1.000 19.11596 ? 20  DC  D C5     1 
ATOM   625  C  C6     . DC  B 2 4  ? -3.60276  -4.68419  -6.78035  1.000 14.33094 ? 20  DC  D C6     1 
ATOM   626  H  "H5'"  . DC  B 2 4  ? -2.36669  -6.62791  -10.21107 1.000 31.13319 ? 20  DC  D "H5'"  1 
ATOM   627  H  "H5''" . DC  B 2 4  ? -0.83014  -6.97781  -10.31627 1.000 31.13319 ? 20  DC  D "H5''" 1 
ATOM   628  H  "H4'"  . DC  B 2 4  ? -0.96362  -4.72911  -10.65644 1.000 21.04519 ? 20  DC  D "H4'"  1 
ATOM   629  H  "H3'"  . DC  B 2 4  ? 0.52928   -5.44923  -8.60282  1.000 17.37712 ? 20  DC  D "H3'"  1 
ATOM   630  H  "H2'"  . DC  B 2 4  ? -0.90999  -4.87768  -6.97346  1.000 16.83758 ? 20  DC  D "H2'"  1 
ATOM   631  H  "H2''" . DC  B 2 4  ? -0.13283  -3.50977  -7.11238  1.000 16.83758 ? 20  DC  D "H2''" 1 
ATOM   632  H  "H1'"  . DC  B 2 4  ? -1.69790  -2.58734  -8.35049  1.000 23.63041 ? 20  DC  D "H1'"  1 
ATOM   633  H  H41    . DC  B 2 4  ? -6.90369  -4.23610  -4.84094  1.000 16.67677 ? 20  DC  D H41    1 
ATOM   634  H  H42    . DC  B 2 4  ? -7.02394  -2.76766  -5.06013  1.000 16.67677 ? 20  DC  D H42    1 
ATOM   635  H  H5     . DC  B 2 4  ? -5.05612  -5.53337  -5.73156  1.000 22.93915 ? 20  DC  D H5     1 
ATOM   636  H  H6     . DC  B 2 4  ? -3.13306  -5.46928  -6.94745  1.000 17.19713 ? 20  DC  D H6     1 
ATOM   637  P  P      . DA  B 2 5  ? 2.33730   -3.51565  -9.12009  1.000 16.84555 ? 21  DA  D P      1 
ATOM   638  O  OP1    . DA  B 2 5  ? 2.90164   -2.82931  -10.31102 1.000 18.37159 ? 21  DA  D OP1    1 
ATOM   639  O  OP2    . DA  B 2 5  ? 2.90111   -4.75334  -8.60893  1.000 17.87200 ? 21  DA  D OP2    1 
ATOM   640  O  "O5'"  . DA  B 2 5  ? 2.26245   -2.47743  -7.91278  1.000 13.15227 ? 21  DA  D "O5'"  1 
ATOM   641  C  "C5'"  . DA  B 2 5  ? 1.94667   -1.16045  -8.13881  1.000 13.66506 ? 21  DA  D "C5'"  1 
ATOM   642  C  "C4'"  . DA  B 2 5  ? 1.63167   -0.47326  -6.82003  1.000 13.07799 ? 21  DA  D "C4'"  1 
ATOM   643  O  "O4'"  . DA  B 2 5  ? 0.35309   -0.93868  -6.30495  1.000 15.27443 ? 21  DA  D "O4'"  1 
ATOM   644  C  "C3'"  . DA  B 2 5  ? 2.64489   -0.74142  -5.70474  1.000 12.09280 ? 21  DA  D "C3'"  1 
ATOM   645  O  "O3'"  . DA  B 2 5  ? 3.01794   0.49135   -5.10873  1.000 13.53502 ? 21  DA  D "O3'"  1 
ATOM   646  C  "C2'"  . DA  B 2 5  ? 1.88122   -1.66293  -4.74160  1.000 12.87134 ? 21  DA  D "C2'"  1 
ATOM   647  C  "C1'"  . DA  B 2 5  ? 0.47722   -1.11831  -4.91468  1.000 12.37119 ? 21  DA  D "C1'"  1 
ATOM   648  N  N9     . DA  B 2 5  ? -0.60427  -1.95863  -4.40162  1.000 11.79897 ? 21  DA  D N9     1 
ATOM   649  C  C8     . DA  B 2 5  ? -0.58771  -3.29669  -4.12661  1.000 11.05074 ? 21  DA  D C8     1 
ATOM   650  N  N7     . DA  B 2 5  ? -1.73814  -3.74894  -3.63073  1.000 14.28514 ? 21  DA  D N7     1 
ATOM   651  C  C5     . DA  B 2 5  ? -2.53152  -2.61756  -3.57858  1.000 13.72408 ? 21  DA  D C5     1 
ATOM   652  C  C6     . DA  B 2 5  ? -3.85284  -2.39086  -3.14187  1.000 15.66372 ? 21  DA  D C6     1 
ATOM   653  N  N6     . DA  B 2 5  ? -4.62710  -3.34556  -2.65180  1.000 14.66889 ? 21  DA  D N6     1 
ATOM   654  N  N1     . DA  B 2 5  ? -4.33599  -1.12953  -3.21949  1.000 14.50432 ? 21  DA  D N1     1 
ATOM   655  C  C2     . DA  B 2 5  ? -3.54901  -0.16852  -3.69018  1.000 16.14271 ? 21  DA  D C2     1 
ATOM   656  N  N3     . DA  B 2 5  ? -2.29236  -0.26179  -4.13115  1.000 13.15284 ? 21  DA  D N3     1 
ATOM   657  C  C4     . DA  B 2 5  ? -1.84437  -1.51611  -4.04084  1.000 12.34666 ? 21  DA  D C4     1 
ATOM   658  H  "H5'"  . DA  B 2 5  ? 1.17471   -1.10820  -8.72384  1.000 16.39808 ? 21  DA  D "H5'"  1 
ATOM   659  H  "H5''" . DA  B 2 5  ? 2.69634   -0.71605  -8.56472  1.000 16.39808 ? 21  DA  D "H5''" 1 
ATOM   660  H  "H4'"  . DA  B 2 5  ? 1.56701   0.48233   -6.97355  1.000 15.69359 ? 21  DA  D "H4'"  1 
ATOM   661  H  "H3'"  . DA  B 2 5  ? 3.42274   -1.21232  -6.04252  1.000 14.51136 ? 21  DA  D "H3'"  1 
ATOM   662  H  "H2'"  . DA  B 2 5  ? 1.94350   -2.59423  -5.00563  1.000 15.44561 ? 21  DA  D "H2'"  1 
ATOM   663  H  "H2''" . DA  B 2 5  ? 2.19489   -1.57197  -3.82824  1.000 15.44561 ? 21  DA  D "H2''" 1 
ATOM   664  H  "H1'"  . DA  B 2 5  ? 0.38702   -0.26972  -4.45353  1.000 14.84543 ? 21  DA  D "H1'"  1 
ATOM   665  H  H8     . DA  B 2 5  ? 0.15407   -3.83862  -4.27143  1.000 13.26088 ? 21  DA  D H8     1 
ATOM   666  H  H61    . DA  B 2 5  ? -5.42444  -3.15977  -2.38847  1.000 17.60267 ? 21  DA  D H61    1 
ATOM   667  H  H62    . DA  B 2 5  ? -4.33296  -4.15181  -2.59663  1.000 17.60267 ? 21  DA  D H62    1 
ATOM   668  H  H2     . DA  B 2 5  ? -3.92319  0.68250   -3.71596  1.000 19.37126 ? 21  DA  D H2     1 
ATOM   669  P  P      . DC  B 2 6  ? 4.32924   0.58817   -4.18643  1.000 13.25175 ? 22  DC  D P      1 
ATOM   670  O  OP1    . DC  B 2 6  ? 4.56421   2.03317   -4.02373  1.000 12.42134 ? 22  DC  D OP1    1 
ATOM   671  O  OP2    . DC  B 2 6  ? 5.37965   -0.31616  -4.72343  1.000 12.59109 ? 22  DC  D OP2    1 
ATOM   672  O  "O5'"  . DC  B 2 6  ? 3.87764   -0.08580  -2.80433  1.000 15.36220 ? 22  DC  D "O5'"  1 
ATOM   673  C  "C5'"  . DC  B 2 6  ? 3.51893   0.71566   -1.68672  1.000 13.07325 ? 22  DC  D "C5'"  1 
ATOM   674  C  "C4'"  . DC  B 2 6  ? 2.14837   1.28344   -1.81322  1.000 12.84459 ? 22  DC  D "C4'"  1 
ATOM   675  O  "O4'"  . DC  B 2 6  ? 1.18998   0.21061   -1.95657  1.000 12.13276 ? 22  DC  D "O4'"  1 
ATOM   676  C  "C3'"  . DC  B 2 6  ? 1.71416   2.08180   -0.56968  1.000 11.03151 ? 22  DC  D "C3'"  1 
ATOM   677  O  "O3'"  . DC  B 2 6  ? 1.41266   3.39922   -0.88875  1.000 12.76062 ? 22  DC  D "O3'"  1 
ATOM   678  C  "C2'"  . DC  B 2 6  ? 0.50130   1.33975   -0.03529  1.000 13.94326 ? 22  DC  D "C2'"  1 
ATOM   679  C  "C1'"  . DC  B 2 6  ? 0.02846   0.55134   -1.24220  1.000 14.39969 ? 22  DC  D "C1'"  1 
ATOM   680  N  N1     . DC  B 2 6  ? -0.71954  -0.66352  -0.86748  1.000 10.86930 ? 22  DC  D N1     1 
ATOM   681  C  C2     . DC  B 2 6  ? -2.06582  -0.52565  -0.52457  1.000 12.14012 ? 22  DC  D C2     1 
ATOM   682  O  O2     . DC  B 2 6  ? -2.58759  0.59069   -0.59031  1.000 12.36894 ? 22  DC  D O2     1 
ATOM   683  N  N3     . DC  B 2 6  ? -2.75429  -1.61426  -0.13832  1.000 12.28410 ? 22  DC  D N3     1 
ATOM   684  C  C4     . DC  B 2 6  ? -2.16460  -2.79761  -0.08129  1.000 14.48598 ? 22  DC  D C4     1 
ATOM   685  N  N4     . DC  B 2 6  ? -2.90962  -3.85343  0.31828   1.000 13.12956 ? 22  DC  D N4     1 
ATOM   686  C  C5     . DC  B 2 6  ? -0.77049  -2.96604  -0.39838  1.000 11.84725 ? 22  DC  D C5     1 
ATOM   687  C  C6     . DC  B 2 6  ? -0.09718  -1.88449  -0.78412  1.000 9.91705  ? 22  DC  D C6     1 
ATOM   688  H  "H5'"  . DC  B 2 6  ? 4.15403   1.44447   -1.60686  1.000 15.68790 ? 22  DC  D "H5'"  1 
ATOM   689  H  "H5''" . DC  B 2 6  ? 3.56007   0.17161   -0.88471  1.000 15.68790 ? 22  DC  D "H5''" 1 
ATOM   690  H  "H4'"  . DC  B 2 6  ? 2.08519   1.84141   -2.60415  1.000 15.41350 ? 22  DC  D "H4'"  1 
ATOM   691  H  "H3'"  . DC  B 2 6  ? 2.43234   2.04430   0.08125   1.000 13.23781 ? 22  DC  D "H3'"  1 
ATOM   692  H  "H2'"  . DC  B 2 6  ? 0.74426   0.75045   0.69587   1.000 16.73191 ? 22  DC  D "H2'"  1 
ATOM   693  H  "H2''" . DC  B 2 6  ? -0.18156  1.95718   0.27029   1.000 16.73191 ? 22  DC  D "H2''" 1 
ATOM   694  H  "H1'"  . DC  B 2 6  ? -0.53162  1.09526   -1.81784  1.000 17.27963 ? 22  DC  D "H1'"  1 
ATOM   695  H  H41    . DC  B 2 6  ? -2.55590  -4.63587  0.36591   1.000 15.75547 ? 22  DC  D H41    1 
ATOM   696  H  H42    . DC  B 2 6  ? -3.73705  -3.74230  0.52471   1.000 15.75547 ? 22  DC  D H42    1 
ATOM   697  H  H5     . DC  B 2 6  ? -0.35707  -3.79677  -0.33624  1.000 14.21670 ? 22  DC  D H5     1 
ATOM   698  H  H6     . DC  B 2 6  ? 0.80465   -1.95669  -0.99950  1.000 11.90046 ? 22  DC  D H6     1 
ATOM   699  P  P      . DT  B 2 7  ? 1.47360   4.50370   0.27261   1.000 11.66575 ? 23  DT  D P      1 
ATOM   700  O  OP1    . DT  B 2 7  ? 1.45401   5.77519   -0.45179  1.000 10.18794 ? 23  DT  D OP1    1 
ATOM   701  O  OP2    . DT  B 2 7  ? 2.55480   4.16828   1.22200   1.000 11.18282 ? 23  DT  D OP2    1 
ATOM   702  O  "O5'"  . DT  B 2 7  ? 0.11469   4.31791   1.07394   1.000 10.44821 ? 23  DT  D "O5'"  1 
ATOM   703  C  "C5'"  . DT  B 2 7  ? -1.09749  4.59865   0.40690   1.000 12.41706 ? 23  DT  D "C5'"  1 
ATOM   704  C  "C4'"  . DT  B 2 7  ? -2.24980  4.48144   1.36081   1.000 11.54967 ? 23  DT  D "C4'"  1 
ATOM   705  O  "O4'"  . DT  B 2 7  ? -2.51688  3.09436   1.64987   1.000 11.68387 ? 23  DT  D "O4'"  1 
ATOM   706  C  "C3'"  . DT  B 2 7  ? -2.03428  5.15354   2.70019   1.000 13.54098 ? 23  DT  D "C3'"  1 
ATOM   707  O  "O3'"  . DT  B 2 7  ? -3.17363  5.97008   2.95512   1.000 12.30651 ? 23  DT  D "O3'"  1 
ATOM   708  C  "C2'"  . DT  B 2 7  ? -1.86930  3.97949   3.69113   1.000 12.99282 ? 23  DT  D "C2'"  1 
ATOM   709  C  "C1'"  . DT  B 2 7  ? -2.73912  2.93690   3.04766   1.000 13.05391 ? 23  DT  D "C1'"  1 
ATOM   710  N  N1     . DT  B 2 7  ? -2.46479  1.53102   3.28984   1.000 10.63593 ? 23  DT  D N1     1 
ATOM   711  C  C2     . DT  B 2 7  ? -3.51677  0.70329   3.58184   1.000 10.62560 ? 23  DT  D C2     1 
ATOM   712  O  O2     . DT  B 2 7  ? -4.62869  1.11399   3.84323   1.000 13.17784 ? 23  DT  D O2     1 
ATOM   713  N  N3     . DT  B 2 7  ? -3.21986  -0.61547  3.63331   1.000 11.79672 ? 23  DT  D N3     1 
ATOM   714  C  C4     . DT  B 2 7  ? -2.00777  -1.20717  3.39891   1.000 13.00348 ? 23  DT  D C4     1 
ATOM   715  O  O4     . DT  B 2 7  ? -1.86338  -2.43704  3.45393   1.000 12.23122 ? 23  DT  D O4     1 
ATOM   716  C  C5     . DT  B 2 7  ? -0.93285  -0.28891  3.06578   1.000 10.96288 ? 23  DT  D C5     1 
ATOM   717  C  C7     . DT  B 2 7  ? 0.46113   -0.79369  2.82614   1.000 11.93917 ? 23  DT  D C7     1 
ATOM   718  C  C6     . DT  B 2 7  ? -1.21653  1.01849   2.99579   1.000 10.84419 ? 23  DT  D C6     1 
ATOM   719  H  "H5'"  . DT  B 2 7  ? -1.21732  3.97073   -0.32266  1.000 14.90048 ? 23  DT  D "H5'"  1 
ATOM   720  H  "H5''" . DT  B 2 7  ? -1.06679  5.49886   0.04694   1.000 14.90048 ? 23  DT  D "H5''" 1 
ATOM   721  H  "H4'"  . DT  B 2 7  ? -3.04100  4.85665   0.94355   1.000 13.85961 ? 23  DT  D "H4'"  1 
ATOM   722  H  "H3'"  . DT  B 2 7  ? -1.21325  5.66942   2.72621   1.000 16.24917 ? 23  DT  D "H3'"  1 
ATOM   723  H  "H2'"  . DT  B 2 7  ? -0.94596  3.68842   3.75126   1.000 15.59139 ? 23  DT  D "H2'"  1 
ATOM   724  H  "H2''" . DT  B 2 7  ? -2.18547  4.21218   4.57815   1.000 15.59139 ? 23  DT  D "H2''" 1 
ATOM   725  H  "H1'"  . DT  B 2 7  ? -3.63827  3.12517   3.35909   1.000 15.66469 ? 23  DT  D "H1'"  1 
ATOM   726  H  H3     . DT  B 2 7  ? -3.86757  -1.14333  3.83686   1.000 14.15607 ? 23  DT  D H3     1 
ATOM   727  H  H71    . DT  B 2 7  ? 0.63953   -1.52883  3.43330   1.000 14.32700 ? 23  DT  D H71    1 
ATOM   728  H  H72    . DT  B 2 7  ? 0.53331   -1.09805  1.90796   1.000 14.32700 ? 23  DT  D H72    1 
ATOM   729  H  H73    . DT  B 2 7  ? 1.08995   -0.07262  2.98599   1.000 14.32700 ? 23  DT  D H73    1 
ATOM   730  H  H6     . DT  B 2 7  ? -0.54368  1.60648   2.73800   1.000 13.01302 ? 23  DT  D H6     1 
ATOM   731  P  P      . DT  B 2 8  ? -3.18838  7.00877   4.16686   1.000 13.93405 ? 24  DT  D P      1 
ATOM   732  O  OP1    . DT  B 2 8  ? -4.07912  8.07009   3.70645   1.000 14.48260 ? 24  DT  D OP1    1 
ATOM   733  O  OP2    . DT  B 2 8  ? -1.83224  7.30832   4.67314   1.000 12.89366 ? 24  DT  D OP2    1 
ATOM   734  O  "O5'"  . DT  B 2 8  ? -3.89927  6.18890   5.33303   1.000 12.85215 ? 24  DT  D "O5'"  1 
ATOM   735  C  "C5'"  . DT  B 2 8  ? -5.25754  5.82337   5.17691   1.000 16.30537 ? 24  DT  D "C5'"  1 
ATOM   736  C  "C4'"  . DT  B 2 8  ? -5.64197  4.78990   6.20255   1.000 13.30547 ? 24  DT  D "C4'"  1 
ATOM   737  O  "O4'"  . DT  B 2 8  ? -4.90401  3.57377   5.99998   1.000 14.64469 ? 24  DT  D "O4'"  1 
ATOM   738  C  "C3'"  . DT  B 2 8  ? -5.34698  5.19084   7.63835   1.000 14.30029 ? 24  DT  D "C3'"  1 
ATOM   739  O  "O3'"  . DT  B 2 8  ? -6.56883  5.52039   8.23009   1.000 15.69489 ? 24  DT  D "O3'"  1 
ATOM   740  C  "C2'"  . DT  B 2 8  ? -4.65445  3.94970   8.26155   1.000 12.26535 ? 24  DT  D "C2'"  1 
ATOM   741  C  "C1'"  . DT  B 2 8  ? -4.91871  2.87562   7.21889   1.000 14.53001 ? 24  DT  D "C1'"  1 
ATOM   742  N  N1     . DT  B 2 8  ? -3.93400  1.75953   7.10459   1.000 13.89842 ? 24  DT  D N1     1 
ATOM   743  C  C2     . DT  B 2 8  ? -4.36532  0.47450   7.28902   1.000 12.89362 ? 24  DT  D C2     1 
ATOM   744  O  O2     . DT  B 2 8  ? -5.51405  0.19106   7.62875   1.000 12.72620 ? 24  DT  D O2     1 
ATOM   745  N  N3     . DT  B 2 8  ? -3.40858  -0.48033  7.09713   1.000 11.75684 ? 24  DT  D N3     1 
ATOM   746  C  C4     . DT  B 2 8  ? -2.09506  -0.27898  6.74984   1.000 11.85444 ? 24  DT  D C4     1 
ATOM   747  O  O4     . DT  B 2 8  ? -1.32999  -1.21350  6.58704   1.000 12.88058 ? 24  DT  D O4     1 
ATOM   748  C  C5     . DT  B 2 8  ? -1.70082  1.09982   6.54895   1.000 11.19697 ? 24  DT  D C5     1 
ATOM   749  C  C7     . DT  B 2 8  ? -0.28226  1.44989   6.18461   1.000 11.95601 ? 24  DT  D C7     1 
ATOM   750  C  C6     . DT  B 2 8  ? -2.63031  2.04586   6.73110   1.000 12.58225 ? 24  DT  D C6     1 
ATOM   751  H  "H5'"  . DT  B 2 8  ? -5.39293  5.46021   4.28770   1.000 19.56644 ? 24  DT  D "H5'"  1 
ATOM   752  H  "H5''" . DT  B 2 8  ? -5.81667  6.60847   5.28590   1.000 19.56644 ? 24  DT  D "H5''" 1 
ATOM   753  H  "H4'"  . DT  B 2 8  ? -6.58597  4.59275   6.09819   1.000 15.96656 ? 24  DT  D "H4'"  1 
ATOM   754  H  "H3'"  . DT  B 2 8  ? -4.71054  5.92078   7.69336   1.000 17.16035 ? 24  DT  D "H3'"  1 
ATOM   755  H  "H2'"  . DT  B 2 8  ? -3.70363  4.09883   8.38238   1.000 14.71842 ? 24  DT  D "H2'"  1 
ATOM   756  H  "H2''" . DT  B 2 8  ? -5.04878  3.71697   9.11668   1.000 14.71842 ? 24  DT  D "H2''" 1 
ATOM   757  H  "H1'"  . DT  B 2 8  ? -5.77604  2.46953   7.42130   1.000 17.43601 ? 24  DT  D "H1'"  1 
ATOM   758  H  H3     . DT  B 2 8  ? -3.65528  -1.29703  7.20553   1.000 14.10821 ? 24  DT  D H3     1 
ATOM   759  H  H71    . DT  B 2 8  ? -0.29123  2.17945   5.54543   1.000 14.34721 ? 24  DT  D H71    1 
ATOM   760  H  H72    . DT  B 2 8  ? 0.19266   1.71856   6.98659   1.000 14.34721 ? 24  DT  D H72    1 
ATOM   761  H  H73    . DT  B 2 8  ? 0.14429   0.67189   5.79259   1.000 14.34721 ? 24  DT  D H73    1 
ATOM   762  H  H6     . DT  B 2 8  ? -2.39054  2.93498   6.60122   1.000 15.09870 ? 24  DT  D H6     1 
ATOM   763  P  P      . DC  B 2 9  ? -6.66109  6.02260   9.73334   1.000 19.19095 ? 25  DC  D P      1 
ATOM   764  O  OP1    . DC  B 2 9  ? -7.99711  6.67319   9.77733   1.000 19.23300 ? 25  DC  D OP1    1 
ATOM   765  O  OP2    . DC  B 2 9  ? -5.46124  6.75869   10.17970  1.000 18.27428 ? 25  DC  D OP2    1 
ATOM   766  O  "O5'"  . DC  B 2 9  ? -6.77366  4.69536   10.59125  1.000 18.19207 ? 25  DC  D "O5'"  1 
ATOM   767  C  "C5'"  . DC  B 2 9  ? -7.85091  3.80985   10.38143  1.000 19.83464 ? 25  DC  D "C5'"  1 
ATOM   768  C  "C4'"  . DC  B 2 9  ? -7.60851  2.50418   11.10386  1.000 22.07673 ? 25  DC  D "C4'"  1 
ATOM   769  O  "O4'"  . DC  B 2 9  ? -6.49608  1.80869   10.49101  1.000 20.21863 ? 25  DC  D "O4'"  1 
ATOM   770  C  "C3'"  . DC  B 2 9  ? -7.21880  2.63509   12.58251  1.000 27.24290 ? 25  DC  D "C3'"  1 
ATOM   771  O  "O3'"  . DC  B 2 9  ? -8.33489  2.31863   13.42367  1.000 25.92187 ? 25  DC  D "O3'"  1 
ATOM   772  C  "C2'"  . DC  B 2 9  ? -6.04145  1.64681   12.75305  1.000 20.70054 ? 25  DC  D "C2'"  1 
ATOM   773  C  "C1'"  . DC  B 2 9  ? -6.02947  0.89199   11.43612  1.000 19.29086 ? 25  DC  D "C1'"  1 
ATOM   774  N  N1     . DC  B 2 9  ? -4.68328  0.38839   10.99798  1.000 14.04425 ? 25  DC  D N1     1 
ATOM   775  C  C2     . DC  B 2 9  ? -4.45842  -0.98736  10.90647  1.000 15.41521 ? 25  DC  D C2     1 
ATOM   776  O  O2     . DC  B 2 9  ? -5.37586  -1.78258  11.19169  1.000 16.95389 ? 25  DC  D O2     1 
ATOM   777  N  N3     . DC  B 2 9  ? -3.24046  -1.42445  10.49929  1.000 13.11766 ? 25  DC  D N3     1 
ATOM   778  C  C4     . DC  B 2 9  ? -2.26775  -0.53945  10.22328  1.000 11.74446 ? 25  DC  D C4     1 
ATOM   779  N  N4     . DC  B 2 9  ? -1.07973  -1.02076  9.81599   1.000 13.02561 ? 25  DC  D N4     1 
ATOM   780  C  C5     . DC  B 2 9  ? -2.48536  0.86000   10.31382  1.000 17.05126 ? 25  DC  D C5     1 
ATOM   781  C  C6     . DC  B 2 9  ? -3.70066  1.27742   10.69793  1.000 14.41675 ? 25  DC  D C6     1 
ATOM   782  H  "H5'"  . DC  B 2 9  ? -7.94596  3.63871   9.43139   1.000 23.80157 ? 25  DC  D "H5'"  1 
ATOM   783  H  "H5''" . DC  B 2 9  ? -8.66820  4.21367   10.71288  1.000 23.80157 ? 25  DC  D "H5''" 1 
ATOM   784  H  "H4'"  . DC  B 2 9  ? -8.40912  1.96140   11.03105  1.000 26.49207 ? 25  DC  D "H4'"  1 
ATOM   785  H  "H3'"  . DC  B 2 9  ? -6.90409  3.53501   12.76141  1.000 32.69148 ? 25  DC  D "H3'"  1 
ATOM   786  H  "H2'"  . DC  B 2 9  ? -5.20580  2.11893   12.89341  1.000 24.84065 ? 25  DC  D "H2'"  1 
ATOM   787  H  "H2''" . DC  B 2 9  ? -6.19402  1.04618   13.49928  1.000 24.84065 ? 25  DC  D "H2''" 1 
ATOM   788  H  "H1'"  . DC  B 2 9  ? -6.62324  0.12748   11.49814  1.000 23.14903 ? 25  DC  D "H1'"  1 
ATOM   789  H  H41    . DC  B 2 9  ? -0.43700  -0.47991  9.63164   1.000 15.63073 ? 25  DC  D H41    1 
ATOM   790  H  H42    . DC  B 2 9  ? -0.96281  -1.86937  9.73990   1.000 15.63073 ? 25  DC  D H42    1 
ATOM   791  H  H5     . DC  B 2 9  ? -1.80908  1.46626   10.11384  1.000 20.46151 ? 25  DC  D H5     1 
ATOM   792  H  H6     . DC  B 2 9  ? -3.87337  2.18914   10.75984  1.000 17.30010 ? 25  DC  D H6     1 
ATOM   793  P  P      . DC  B 2 10 ? -8.23225  2.49508   15.01442  1.000 28.59541 ? 26  DC  D P      1 
ATOM   794  O  OP1    . DC  B 2 10 ? -9.64639  2.51169   15.44493  1.000 40.70367 ? 26  DC  D OP1    1 
ATOM   795  O  OP2    . DC  B 2 10 ? -7.29711  3.53839   15.44320  1.000 25.14280 ? 26  DC  D OP2    1 
ATOM   796  O  "O5'"  . DC  B 2 10 ? -7.59221  1.12036   15.49738  1.000 24.89203 ? 26  DC  D "O5'"  1 
ATOM   797  C  "C5'"  . DC  B 2 10 ? -8.17591  -0.07443  15.06935  1.000 25.71156 ? 26  DC  D "C5'"  1 
ATOM   798  C  "C4'"  . DC  B 2 10 ? -7.32889  -1.23978  15.48426  1.000 27.04703 ? 26  DC  D "C4'"  1 
ATOM   799  O  "O4'"  . DC  B 2 10 ? -6.14451  -1.27691  14.66393  1.000 26.91587 ? 26  DC  D "O4'"  1 
ATOM   800  C  "C3'"  . DC  B 2 10 ? -6.84047  -1.18154  16.93157  1.000 31.04965 ? 26  DC  D "C3'"  1 
ATOM   801  O  "O3'"  . DC  B 2 10 ? -7.52023  -2.16745  17.67880  1.000 33.03436 ? 26  DC  D "O3'"  1 
ATOM   802  C  "C2'"  . DC  B 2 10 ? -5.31346  -1.41598  16.83728  1.000 32.63554 ? 26  DC  D "C2'"  1 
ATOM   803  C  "C1'"  . DC  B 2 10 ? -5.11066  -1.86833  15.39318  1.000 27.60048 ? 26  DC  D "C1'"  1 
ATOM   804  N  N1     . DC  B 2 10 ? -3.81695  -1.45014  14.75243  1.000 23.88053 ? 26  DC  D N1     1 
ATOM   805  C  C2     . DC  B 2 10 ? -2.95203  -2.42296  14.24555  1.000 23.23871 ? 26  DC  D C2     1 
ATOM   806  O  O2     . DC  B 2 10 ? -3.24514  -3.61547  14.37617  1.000 21.81213 ? 26  DC  D O2     1 
ATOM   807  N  N3     . DC  B 2 10 ? -1.79138  -2.02939  13.65614  1.000 19.16246 ? 26  DC  D N3     1 
ATOM   808  C  C4     . DC  B 2 10 ? -1.51171  -0.73271  13.53868  1.000 16.91687 ? 26  DC  D C4     1 
ATOM   809  N  N4     . DC  B 2 10 ? -0.37944  -0.39343  12.93391  1.000 18.22671 ? 26  DC  D N4     1 
ATOM   810  C  C5     . DC  B 2 10 ? -2.38493  0.27495   14.03756  1.000 21.86818 ? 26  DC  D C5     1 
ATOM   811  C  C6     . DC  B 2 10 ? -3.52133  -0.12604  14.62744  1.000 17.61509 ? 26  DC  D C6     1 
ATOM   812  H  "H5'"  . DC  B 2 10 ? -8.25983  -0.06444  14.10304  1.000 30.85387 ? 26  DC  D "H5'"  1 
ATOM   813  H  "H5''" . DC  B 2 10 ? -9.05858  -0.16112  15.46212  1.000 30.85387 ? 26  DC  D "H5''" 1 
ATOM   814  H  "H4'"  . DC  B 2 10 ? -7.82076  -2.06556  15.35363  1.000 32.45644 ? 26  DC  D "H4'"  1 
ATOM   815  H  "H3'"  . DC  B 2 10 ? -6.97834  -0.29964  17.31122  1.000 37.25958 ? 26  DC  D "H3'"  1 
ATOM   816  H  "H2'"  . DC  B 2 10 ? -4.82335  -0.59883  17.01881  1.000 39.16265 ? 26  DC  D "H2'"  1 
ATOM   817  H  "H2''" . DC  B 2 10 ? -5.02673  -2.10137  17.46091  1.000 39.16265 ? 26  DC  D "H2''" 1 
ATOM   818  H  "H1'"  . DC  B 2 10 ? -5.16601  -2.83650  15.37091  1.000 33.12058 ? 26  DC  D "H1'"  1 
ATOM   819  H  H41    . DC  B 2 10 ? -0.17218  0.43630   12.84341  1.000 21.87206 ? 26  DC  D H41    1 
ATOM   820  H  H42    . DC  B 2 10 ? 0.14668   -1.00340  12.63270  1.000 21.87206 ? 26  DC  D H42    1 
ATOM   821  H  H5     . DC  B 2 10 ? -2.17547  1.17751   13.95755  1.000 26.24181 ? 26  DC  D H5     1 
ATOM   822  H  H6     . DC  B 2 10 ? -4.11596  0.50916   14.95582  1.000 21.13811 ? 26  DC  D H6     1 
ATOM   823  P  P      . DG  B 2 11 ? -7.37371  -2.26675  19.27441  1.000 33.79560 ? 27  DG  D P      1 
ATOM   824  O  OP1    . DG  B 2 11 ? -8.64081  -2.88293  19.71644  1.000 40.95739 ? 27  DG  D OP1    1 
ATOM   825  O  OP2    . DG  B 2 11 ? -6.85368  -1.00392  19.84058  1.000 38.26919 ? 27  DG  D OP2    1 
ATOM   826  O  "O5'"  . DG  B 2 11 ? -6.18509  -3.32383  19.46384  1.000 33.33941 ? 27  DG  D "O5'"  1 
ATOM   827  C  "C5'"  . DG  B 2 11 ? -6.32705  -4.60268  18.90948  1.000 31.31597 ? 27  DG  D "C5'"  1 
ATOM   828  C  "C4'"  . DG  B 2 11 ? -5.03360  -5.36250  18.99970  1.000 33.29767 ? 27  DG  D "C4'"  1 
ATOM   829  O  "O4'"  . DG  B 2 11 ? -4.08293  -4.80669  18.05278  1.000 29.10562 ? 27  DG  D "O4'"  1 
ATOM   830  C  "C3'"  . DG  B 2 11 ? -4.35969  -5.30457  20.37816  1.000 32.47718 ? 27  DG  D "C3'"  1 
ATOM   831  O  "O3'"  . DG  B 2 11 ? -4.09893  -6.62682  20.83266  1.000 44.91829 ? 27  DG  D "O3'"  1 
ATOM   832  C  "C2'"  . DG  B 2 11 ? -3.09560  -4.48322  20.12542  1.000 35.26201 ? 27  DG  D "C2'"  1 
ATOM   833  C  "C1'"  . DG  B 2 11 ? -2.82110  -4.77208  18.65381  1.000 27.83866 ? 27  DG  D "C1'"  1 
ATOM   834  N  N9     . DG  B 2 11 ? -1.98011  -3.78256  17.97957  1.000 24.97187 ? 27  DG  D N9     1 
ATOM   835  C  C8     . DG  B 2 11 ? -2.04298  -2.41059  18.07657  1.000 22.69564 ? 27  DG  D C8     1 
ATOM   836  N  N7     . DG  B 2 11 ? -1.13668  -1.79385  17.35177  1.000 25.14585 ? 27  DG  D N7     1 
ATOM   837  C  C5     . DG  B 2 11 ? -0.43050  -2.82852  16.74668  1.000 23.41556 ? 27  DG  D C5     1 
ATOM   838  C  C6     . DG  B 2 11 ? 0.67595   -2.78635  15.86801  1.000 19.52554 ? 27  DG  D C6     1 
ATOM   839  O  O6     . DG  B 2 11 ? 1.26402   -1.79546  15.42607  1.000 19.91609 ? 27  DG  D O6     1 
ATOM   840  N  N1     . DG  B 2 11 ? 1.09425   -4.06277  15.50649  1.000 19.05585 ? 27  DG  D N1     1 
ATOM   841  C  C2     . DG  B 2 11 ? 0.50713   -5.22931  15.91999  1.000 20.88533 ? 27  DG  D C2     1 
ATOM   842  N  N2     . DG  B 2 11 ? 1.03400   -6.35857  15.44559  1.000 20.54124 ? 27  DG  D N2     1 
ATOM   843  N  N3     . DG  B 2 11 ? -0.53223  -5.28860  16.74245  1.000 19.99838 ? 27  DG  D N3     1 
ATOM   844  C  C4     . DG  B 2 11 ? -0.93696  -4.05515  17.12324  1.000 22.44591 ? 27  DG  D C4     1 
ATOM   845  H  "H5'"  . DG  B 2 11 ? -6.58762  -4.52191  17.97864  1.000 37.57916 ? 27  DG  D "H5'"  1 
ATOM   846  H  "H5''" . DG  B 2 11 ? -7.01739  -5.08595  19.38988  1.000 37.57916 ? 27  DG  D "H5''" 1 
ATOM   847  H  "H4'"  . DG  B 2 11 ? -5.18259  -6.29216  18.76636  1.000 39.95720 ? 27  DG  D "H4'"  1 
ATOM   848  H  "H3'"  . DG  B 2 11 ? -4.91155  -4.83014  21.01947  1.000 38.97261 ? 27  DG  D "H3'"  1 
ATOM   849  H  "H2'"  . DG  B 2 11 ? -3.25020  -3.53795  20.27857  1.000 42.31441 ? 27  DG  D "H2'"  1 
ATOM   850  H  "H2''" . DG  B 2 11 ? -2.36238  -4.77847  20.68767  1.000 42.31441 ? 27  DG  D "H2''" 1 
ATOM   851  H  "H1'"  . DG  B 2 11 ? -2.38414  -5.63306  18.56065  1.000 33.40639 ? 27  DG  D "H1'"  1 
ATOM   852  H  H8     . DG  B 2 11 ? -2.66581  -1.96404  18.60343  1.000 27.23476 ? 27  DG  D H8     1 
ATOM   853  H  H1     . DG  B 2 11 ? 1.77382   -4.12431  14.98305  1.000 22.86702 ? 27  DG  D H1     1 
ATOM   854  H  H21    . DG  B 2 11 ? 0.70005   -7.11771  15.67316  1.000 24.64949 ? 27  DG  D H21    1 
ATOM   855  H  H22    . DG  B 2 11 ? 1.70778   -6.32779  14.91204  1.000 24.64949 ? 27  DG  D H22    1 
ATOM   856  P  P      . DC  B 2 12 ? -3.40459  -6.91214  22.25560  1.000 35.26035 ? 28  DC  D P      1 
ATOM   857  O  OP1    . DC  B 2 12 ? -4.11657  -8.05567  22.84428  1.000 41.97530 ? 28  DC  D OP1    1 
ATOM   858  O  OP2    . DC  B 2 12 ? -3.18850  -5.64531  22.98475  1.000 40.27596 ? 28  DC  D OP2    1 
ATOM   859  O  "O5'"  . DC  B 2 12 ? -1.98343  -7.46269  21.84547  1.000 36.92388 ? 28  DC  D "O5'"  1 
ATOM   860  C  "C5'"  . DC  B 2 12 ? -1.88911  -8.36043  20.76882  1.000 39.43699 ? 28  DC  D "C5'"  1 
ATOM   861  C  "C4'"  . DC  B 2 12 ? -0.47589  -8.41938  20.28270  1.000 36.05203 ? 28  DC  D "C4'"  1 
ATOM   862  O  "O4'"  . DC  B 2 12 ? -0.14412  -7.18551  19.61672  1.000 36.79659 ? 28  DC  D "O4'"  1 
ATOM   863  C  "C3'"  . DC  B 2 12 ? 0.55498   -8.58146  21.40152  1.000 29.38559 ? 28  DC  D "C3'"  1 
ATOM   864  O  "O3'"  . DC  B 2 12 ? 1.14383   -9.82376  21.29793  1.000 37.46046 ? 28  DC  D "O3'"  1 
ATOM   865  C  "C2'"  . DC  B 2 12 ? 1.54174   -7.43991  21.18111  1.000 27.89565 ? 28  DC  D "C2'"  1 
ATOM   866  C  "C1'"  . DC  B 2 12 ? 1.22622   -6.98966  19.76015  1.000 27.56804 ? 28  DC  D "C1'"  1 
ATOM   867  N  N1     . DC  B 2 12 ? 1.55728   -5.57778  19.47862  1.000 25.54422 ? 28  DC  D N1     1 
ATOM   868  C  C2     . DC  B 2 12 ? 2.62203   -5.30109  18.62667  1.000 18.31811 ? 28  DC  D C2     1 
ATOM   869  O  O2     . DC  B 2 12 ? 3.23988   -6.24306  18.13536  1.000 24.76277 ? 28  DC  D O2     1 
ATOM   870  N  N3     . DC  B 2 12 ? 2.94233   -4.02367  18.37757  1.000 19.71609 ? 28  DC  D N3     1 
ATOM   871  C  C4     . DC  B 2 12 ? 2.25425   -3.03685  18.94091  1.000 19.86855 ? 28  DC  D C4     1 
ATOM   872  N  N4     . DC  B 2 12 ? 2.61848   -1.79276  18.66900  1.000 22.87649 ? 28  DC  D N4     1 
ATOM   873  C  C5     . DC  B 2 12 ? 1.15712   -3.29100  19.81273  1.000 26.36011 ? 28  DC  D C5     1 
ATOM   874  C  C6     . DC  B 2 12 ? 0.84675   -4.56609  20.05397  1.000 22.27509 ? 28  DC  D C6     1 
ATOM   875  H  "H5'"  . DC  B 2 12 ? -2.46760  -8.06470  20.04855  1.000 47.32439 ? 28  DC  D "H5'"  1 
ATOM   876  H  "H5''" . DC  B 2 12 ? -2.16980  -9.24303  21.05717  1.000 47.32439 ? 28  DC  D "H5''" 1 
ATOM   877  H  "H4'"  . DC  B 2 12 ? -0.37780  -9.14347  19.64476  1.000 43.26244 ? 28  DC  D "H4'"  1 
ATOM   878  H  "H3'"  . DC  B 2 12 ? 0.13693   -8.46089  22.26847  1.000 35.26271 ? 28  DC  D "H3'"  1 
ATOM   879  H  "H2'"  . DC  B 2 12 ? 1.39661   -6.72230  21.81741  1.000 33.47478 ? 28  DC  D "H2'"  1 
ATOM   880  H  "H2''" . DC  B 2 12 ? 2.45830   -7.74832  21.25656  1.000 33.47478 ? 28  DC  D "H2''" 1 
ATOM   881  H  "H1'"  . DC  B 2 12 ? 1.70773   -7.53775  19.12090  1.000 33.08164 ? 28  DC  D "H1'"  1 
ATOM   882  H  H41    . DC  B 2 12 ? 2.19158   -1.13343  19.01920  1.000 27.45179 ? 28  DC  D H41    1 
ATOM   883  H  H42    . DC  B 2 12 ? 3.28187   -1.64431  18.14223  1.000 27.45179 ? 28  DC  D H42    1 
ATOM   884  H  H5     . DC  B 2 12 ? 0.67572   -2.59526  20.19887  1.000 31.63213 ? 28  DC  D H5     1 
ATOM   885  H  H6     . DC  B 2 12 ? 0.13761   -4.76715  20.62107  1.000 26.73010 ? 28  DC  D H6     1 
ATOM   886  P  P      . DT  B 2 13 ? 2.21532   -10.30537 22.38198  1.000 33.35006 ? 29  DT  D P      1 
ATOM   887  O  OP1    . DT  B 2 13 ? 2.14755   -11.77537 22.27836  1.000 31.72206 ? 29  DT  D OP1    1 
ATOM   888  O  OP2    . DT  B 2 13 ? 2.05790   -9.56018  23.64669  1.000 30.49463 ? 29  DT  D OP2    1 
ATOM   889  O  "O5'"  . DT  B 2 13 ? 3.61245   -9.83857  21.75181  1.000 26.68787 ? 29  DT  D "O5'"  1 
ATOM   890  C  "C5'"  . DT  B 2 13 ? 4.03555   -10.39851 20.53530  1.000 21.63102 ? 29  DT  D "C5'"  1 
ATOM   891  C  "C4'"  . DT  B 2 13 ? 5.44154   -9.97979  20.21167  1.000 21.90167 ? 29  DT  D "C4'"  1 
ATOM   892  O  "O4'"  . DT  B 2 13 ? 5.47689   -8.56545  19.94526  1.000 22.04932 ? 29  DT  D "O4'"  1 
ATOM   893  C  "C3'"  . DT  B 2 13 ? 6.44353   -10.23260 21.33245  1.000 18.39615 ? 29  DT  D "C3'"  1 
ATOM   894  O  "O3'"  . DT  B 2 13 ? 7.53585   -10.90445 20.81629  1.000 23.87690 ? 29  DT  D "O3'"  1 
ATOM   895  C  "C2'"  . DT  B 2 13 ? 6.81144   -8.83848  21.84535  1.000 22.42324 ? 29  DT  D "C2'"  1 
ATOM   896  C  "C1'"  . DT  B 2 13 ? 6.59942   -7.99434  20.61074  1.000 24.61754 ? 29  DT  D "C1'"  1 
ATOM   897  N  N1     . DT  B 2 13 ? 6.27842   -6.59747  20.83881  1.000 19.19728 ? 29  DT  D N1     1 
ATOM   898  C  C2     . DT  B 2 13 ? 7.06304   -5.61823  20.25773  1.000 15.49113 ? 29  DT  D C2     1 
ATOM   899  O  O2     . DT  B 2 13 ? 8.07515   -5.84932  19.63623  1.000 19.97277 ? 29  DT  D O2     1 
ATOM   900  N  N3     . DT  B 2 13 ? 6.62193   -4.35470  20.45847  1.000 19.09478 ? 29  DT  D N3     1 
ATOM   901  C  C4     . DT  B 2 13 ? 5.49418   -3.96846  21.15761  1.000 17.18796 ? 29  DT  D C4     1 
ATOM   902  O  O4     . DT  B 2 13 ? 5.17232   -2.79575  21.28483  1.000 20.61695 ? 29  DT  D O4     1 
ATOM   903  C  C5     . DT  B 2 13 ? 4.71495   -5.03849  21.72563  1.000 17.71163 ? 29  DT  D C5     1 
ATOM   904  C  C7     . DT  B 2 13 ? 3.48750   -4.72364  22.52042  1.000 17.91540 ? 29  DT  D C7     1 
ATOM   905  C  C6     . DT  B 2 13 ? 5.12606   -6.28462  21.52467  1.000 16.34778 ? 29  DT  D C6     1 
ATOM   906  H  "H5'"  . DT  B 2 13 ? 3.44346   -10.10451 19.82544  1.000 25.95723 ? 29  DT  D "H5'"  1 
ATOM   907  H  "H5''" . DT  B 2 13 ? 3.99698   -11.36568 20.59845  1.000 25.95723 ? 29  DT  D "H5''" 1 
ATOM   908  H  "H4'"  . DT  B 2 13 ? 5.74215   -10.43981 19.41235  1.000 26.28201 ? 29  DT  D "H4'"  1 
ATOM   909  H  "H3'"  . DT  B 2 13 ? 6.02442   -10.72750 22.05379  1.000 22.07539 ? 29  DT  D "H3'"  1 
ATOM   910  H  "H2'"  . DT  B 2 13 ? 6.22988   -8.56103  22.57041  1.000 26.90789 ? 29  DT  D "H2'"  1 
ATOM   911  H  "H2''" . DT  B 2 13 ? 7.73242   -8.80200  22.14762  1.000 26.90789 ? 29  DT  D "H2''" 1 
ATOM   912  H  "H1'"  . DT  B 2 13 ? 7.40815   -8.04425  20.07748  1.000 29.54105 ? 29  DT  D "H1'"  1 
ATOM   913  H  H3     . DT  B 2 13 ? 7.09434   -3.72412  20.11381  1.000 22.91374 ? 29  DT  D H3     1 
ATOM   914  H  H71    . DT  B 2 13 ? 2.70422   -4.94363  21.99224  1.000 21.49848 ? 29  DT  D H71    1 
ATOM   915  H  H72    . DT  B 2 13 ? 3.49537   -5.24973  23.33532  1.000 21.49848 ? 29  DT  D H72    1 
ATOM   916  H  H73    . DT  B 2 13 ? 3.48547   -3.77816  22.73710  1.000 21.49848 ? 29  DT  D H73    1 
ATOM   917  H  H6     . DT  B 2 13 ? 4.61053   -6.98045  21.86371  1.000 19.61733 ? 29  DT  D H6     1 
ATOM   918  P  P      . DT  B 2 14 ? 8.67176   -11.46555 21.78539  1.000 25.67139 ? 30  DT  D P      1 
ATOM   919  O  OP1    . DT  B 2 14 ? 9.19224   -12.66322 21.09301  1.000 27.53036 ? 30  DT  D OP1    1 
ATOM   920  O  OP2    . DT  B 2 14 ? 8.17636   -11.55972 23.18621  1.000 22.52089 ? 30  DT  D OP2    1 
ATOM   921  O  "O5'"  . DT  B 2 14 ? 9.81061   -10.34004 21.74104  1.000 27.24329 ? 30  DT  D "O5'"  1 
ATOM   922  C  "C5'"  . DT  B 2 14 ? 10.40362  -9.99007  20.50481  1.000 25.20676 ? 30  DT  D "C5'"  1 
ATOM   923  C  "C4'"  . DT  B 2 14 ? 11.33256  -8.80958  20.67901  1.000 19.88573 ? 30  DT  D "C4'"  1 
ATOM   924  O  "O4'"  . DT  B 2 14 ? 10.53379  -7.63523  20.94594  1.000 21.97738 ? 30  DT  D "O4'"  1 
ATOM   925  C  "C3'"  . DT  B 2 14 ? 12.34129  -8.92156  21.83384  1.000 20.82360 ? 30  DT  D "C3'"  1 
ATOM   926  O  "O3'"  . DT  B 2 14 ? 13.70069  -8.81597  21.29673  1.000 22.61034 ? 30  DT  D "O3'"  1 
ATOM   927  C  "C2'"  . DT  B 2 14 ? 11.96784  -7.75583  22.77655  1.000 19.12423 ? 30  DT  D "C2'"  1 
ATOM   928  C  "C1'"  . DT  B 2 14 ? 11.23560  -6.80393  21.84131  1.000 18.16965 ? 30  DT  D "C1'"  1 
ATOM   929  N  N1     . DT  B 2 14 ? 10.24359  -5.86987  22.44494  1.000 16.96054 ? 30  DT  D N1     1 
ATOM   930  C  C2     . DT  B 2 14 ? 10.29041  -4.54769  22.08152  1.000 14.93817 ? 30  DT  D C2     1 
ATOM   931  O  O2     . DT  B 2 14 ? 11.17620  -4.08512  21.38417  1.000 18.43201 ? 30  DT  D O2     1 
ATOM   932  N  N3     . DT  B 2 14 ? 9.30316   -3.77178  22.60748  1.000 17.90419 ? 30  DT  D N3     1 
ATOM   933  C  C4     . DT  B 2 14 ? 8.27151   -4.16633  23.42970  1.000 16.68116 ? 30  DT  D C4     1 
ATOM   934  O  O4     . DT  B 2 14 ? 7.43424   -3.37215  23.85528  1.000 17.59819 ? 30  DT  D O4     1 
ATOM   935  C  C5     . DT  B 2 14 ? 8.25030   -5.57383  23.75769  1.000 14.27668 ? 30  DT  D C5     1 
ATOM   936  C  C7     . DT  B 2 14 ? 7.15975   -6.12598  24.63454  1.000 16.13730 ? 30  DT  D C7     1 
ATOM   937  C  C6     . DT  B 2 14 ? 9.21330   -6.35645  23.23937  1.000 13.08448 ? 30  DT  D C6     1 
ATOM   938  H  "H5'"  . DT  B 2 14 ? 9.70829   -9.76044  19.86866  1.000 30.24811 ? 30  DT  D "H5'"  1 
ATOM   939  H  "H5''" . DT  B 2 14 ? 10.90608  -10.74659 20.16406  1.000 30.24811 ? 30  DT  D "H5''" 1 
ATOM   940  H  "H4'"  . DT  B 2 14 ? 11.83843  -8.67291  19.86272  1.000 23.86288 ? 30  DT  D "H4'"  1 
ATOM   941  H  "H3'"  . DT  B 2 14 ? 12.22273  -9.75441  22.31674  1.000 24.98832 ? 30  DT  D "H3'"  1 
ATOM   942  H  "H2'"  . DT  B 2 14 ? 11.39220  -8.05512  23.49763  1.000 22.94908 ? 30  DT  D "H2'"  1 
ATOM   943  H  "H2''" . DT  B 2 14 ? 12.75844  -7.34055  23.15523  1.000 22.94908 ? 30  DT  D "H2''" 1 
ATOM   944  H  "H1'"  . DT  B 2 14 ? 11.90844  -6.26164  21.40074  1.000 21.80358 ? 30  DT  D "H1'"  1 
ATOM   945  H  H3     . DT  B 2 14 ? 9.32659   -2.93700  22.40205  1.000 21.48502 ? 30  DT  D H3     1 
ATOM   946  H  H71    . DT  B 2 14 ? 6.64327   -6.77168  24.12738  1.000 19.36476 ? 30  DT  D H71    1 
ATOM   947  H  H72    . DT  B 2 14 ? 7.56174   -6.55610  25.40544  1.000 19.36476 ? 30  DT  D H72    1 
ATOM   948  H  H73    . DT  B 2 14 ? 6.58744   -5.39787  24.92301  1.000 19.36476 ? 30  DT  D H73    1 
ATOM   949  H  H6     . DT  B 2 14 ? 9.18821   -7.26804  23.42176  1.000 15.70137 ? 30  DT  D H6     1 
ATOM   950  P  P      . DA  B 2 15 ? 14.99642  -8.91046  22.23302  1.000 24.60751 ? 31  DA  D P      1 
ATOM   951  O  OP1    . DA  B 2 15 ? 16.08692  -9.42281  21.35985  1.000 24.05052 ? 31  DA  D OP1    1 
ATOM   952  O  OP2    . DA  B 2 15 ? 14.73265  -9.57124  23.53287  1.000 21.50868 ? 31  DA  D OP2    1 
ATOM   953  O  "O5'"  . DA  B 2 15 ? 15.37160  -7.38052  22.49856  1.000 25.05610 ? 31  DA  D "O5'"  1 
ATOM   954  C  "C5'"  . DA  B 2 15 ? 15.49995  -6.49346  21.40302  1.000 25.90040 ? 31  DA  D "C5'"  1 
ATOM   955  C  "C4'"  . DA  B 2 15 ? 15.78627  -5.08171  21.88236  1.000 23.14946 ? 31  DA  D "C4'"  1 
ATOM   956  O  "O4'"  . DA  B 2 15 ? 14.53003  -4.45240  22.28671  1.000 21.70772 ? 31  DA  D "O4'"  1 
ATOM   957  C  "C3'"  . DA  B 2 15 ? 16.70689  -4.97752  23.10737  1.000 24.59025 ? 31  DA  D "C3'"  1 
ATOM   958  O  "O3'"  . DA  B 2 15 ? 17.57445  -3.87443  22.97105  1.000 22.88816 ? 31  DA  D "O3'"  1 
ATOM   959  C  "C2'"  . DA  B 2 15 ? 15.71767  -4.74268  24.23776  1.000 17.12436 ? 31  DA  D "C2'"  1 
ATOM   960  C  "C1'"  . DA  B 2 15 ? 14.75632  -3.81814  23.52282  1.000 16.45885 ? 31  DA  D "C1'"  1 
ATOM   961  N  N9     . DA  B 2 15 ? 13.47792  -3.57076  24.16636  1.000 14.06543 ? 31  DA  D N9     1 
ATOM   962  C  C8     . DA  B 2 15 ? 12.65636  -4.46843  24.78456  1.000 14.88499 ? 31  DA  D C8     1 
ATOM   963  N  N7     . DA  B 2 15 ? 11.54300  -3.93592  25.24000  1.000 12.04801 ? 31  DA  D N7     1 
ATOM   964  C  C5     . DA  B 2 15 ? 11.65746  -2.59177  24.89778  1.000 12.60167 ? 31  DA  D C5     1 
ATOM   965  C  C6     . DA  B 2 15 ? 10.80746  -1.48566  25.07644  1.000 12.61900 ? 31  DA  D C6     1 
ATOM   966  N  N6     . DA  B 2 15 ? 9.63163   -1.55243  25.69050  1.000 14.76441 ? 31  DA  D N6     1 
ATOM   967  N  N1     . DA  B 2 15 ? 11.21653  -0.29207  24.59492  1.000 13.26158 ? 31  DA  D N1     1 
ATOM   968  C  C2     . DA  B 2 15 ? 12.40607  -0.21538  23.99058  1.000 13.59698 ? 31  DA  D C2     1 
ATOM   969  N  N3     . DA  B 2 15 ? 13.27812  -1.18937  23.73114  1.000 15.47808 ? 31  DA  D N3     1 
ATOM   970  C  C4     . DA  B 2 15 ? 12.83927  -2.36016  24.22815  1.000 14.38955 ? 31  DA  D C4     1 
ATOM   971  H  "H5'"  . DA  B 2 15 ? 14.67611  -6.49638  20.89100  1.000 31.08048 ? 31  DA  D "H5'"  1 
ATOM   972  H  "H5''" . DA  B 2 15 ? 16.22663  -6.79142  20.83376  1.000 31.08048 ? 31  DA  D "H5''" 1 
ATOM   973  H  "H4'"  . DA  B 2 15 ? 16.18151  -4.57608  21.15502  1.000 27.77936 ? 31  DA  D "H4'"  1 
ATOM   974  H  "H3'"  . DA  B 2 15 ? 17.20213  -5.80224  23.23174  1.000 29.50830 ? 31  DA  D "H3'"  1 
ATOM   975  H  "H2'"  . DA  B 2 15 ? 15.28947  -5.56404  24.52571  1.000 20.54923 ? 31  DA  D "H2'"  1 
ATOM   976  H  "H2''" . DA  B 2 15 ? 16.13252  -4.31723  25.00444  1.000 20.54923 ? 31  DA  D "H2''" 1 
ATOM   977  H  "H1'"  . DA  B 2 15 ? 15.17595  -2.95013  23.41615  1.000 19.75062 ? 31  DA  D "H1'"  1 
ATOM   978  H  H8     . DA  B 2 15 ? 12.86386  -5.37044  24.87517  1.000 17.86199 ? 31  DA  D H8     1 
ATOM   979  H  H61    . DA  B 2 15 ? 9.14945   -0.84525  25.77418  1.000 17.71729 ? 31  DA  D H61    1 
ATOM   980  H  H62    . DA  B 2 15 ? 9.35246   -2.30285  26.00442  1.000 17.71729 ? 31  DA  D H62    1 
ATOM   981  H  H2     . DA  B 2 15 ? 12.66044  0.63490   23.71272  1.000 16.31638 ? 31  DA  D H2     1 
ATOM   982  P  P      . DT  B 2 16 ? 19.06219  -4.04305  22.41176  1.000 31.71004 ? 32  DT  D P      1 
ATOM   983  O  OP1    . DT  B 2 16 ? 19.02657  -4.97474  21.26331  1.000 46.87667 ? 32  DT  D OP1    1 
ATOM   984  O  OP2    . DT  B 2 16 ? 19.90135  -4.36200  23.57841  1.000 38.09627 ? 32  DT  D OP2    1 
ATOM   985  O  "O5'"  . DT  B 2 16 ? 19.39699  -2.58287  21.86867  1.000 40.30046 ? 32  DT  D "O5'"  1 
ATOM   986  N  N      . LYS C 3 5  ? 1.93155   6.84354   -10.98363 1.000 54.77536 ? 169 LYS F N      1 
ATOM   987  C  CA     . LYS C 3 5  ? 2.66126   7.28600   -9.79786  1.000 50.97214 ? 169 LYS F CA     1 
ATOM   988  C  C      . LYS C 3 5  ? 3.91762   6.43983   -9.57040  1.000 54.25577 ? 169 LYS F C      1 
ATOM   989  O  O      . LYS C 3 5  ? 4.02634   5.30440   -10.03654 1.000 58.25023 ? 169 LYS F O      1 
ATOM   990  C  CB     . LYS C 3 5  ? 1.76408   7.23330   -8.54792  1.000 34.17568 ? 169 LYS F CB     1 
ATOM   991  H  HA     . LYS C 3 5  ? 2.93547   8.20661   -9.93273  1.000 61.16657 ? 169 LYS F HA     1 
ATOM   992  N  N      . ILE C 3 6  ? 4.85584   7.02151   -8.84375  1.000 30.30947 ? 170 ILE F N      1 
ATOM   993  C  CA     . ILE C 3 6  ? 6.13453   6.39903   -8.53555  1.000 23.41944 ? 170 ILE F CA     1 
ATOM   994  C  C      . ILE C 3 6  ? 5.95199   5.37409   -7.42145  1.000 20.35109 ? 170 ILE F C      1 
ATOM   995  O  O      . ILE C 3 6  ? 5.12594   5.54576   -6.52072  1.000 26.61966 ? 170 ILE F O      1 
ATOM   996  C  CB     . ILE C 3 6  ? 7.13326   7.49920   -8.13570  1.000 29.06212 ? 170 ILE F CB     1 
ATOM   997  C  CG1    . ILE C 3 6  ? 8.50775   6.92310   -7.85572  1.000 27.56772 ? 170 ILE F CG1    1 
ATOM   998  C  CG2    . ILE C 3 6  ? 6.60302   8.26063   -6.92882  1.000 38.62121 ? 170 ILE F CG2    1 
ATOM   999  C  CD1    . ILE C 3 6  ? 9.54435   7.98639   -7.65472  1.000 31.90600 ? 170 ILE F CD1    1 
ATOM   1000 H  H      . ILE C 3 6  ? 4.77549   7.80715   -8.50328  1.000 36.37136 ? 170 ILE F H      1 
ATOM   1001 H  HA     . ILE C 3 6  ? 6.47151   5.92523   -9.31200  1.000 28.10333 ? 170 ILE F HA     1 
ATOM   1002 H  HB     . ILE C 3 6  ? 7.22631   8.11308   -8.88095  1.000 34.87454 ? 170 ILE F HB     1 
ATOM   1003 H  HG12   . ILE C 3 6  ? 8.46757   6.38498   -7.04967  1.000 33.08127 ? 170 ILE F HG12   1 
ATOM   1004 H  HG13   . ILE C 3 6  ? 8.78050   6.37441   -8.60767  1.000 33.08127 ? 170 ILE F HG13   1 
ATOM   1005 H  HG21   . ILE C 3 6  ? 7.24314   8.18831   -6.20362  1.000 46.34546 ? 170 ILE F HG21   1 
ATOM   1006 H  HG22   . ILE C 3 6  ? 6.48175   9.19196   -7.17134  1.000 46.34546 ? 170 ILE F HG22   1 
ATOM   1007 H  HG23   . ILE C 3 6  ? 5.75419   7.87548   -6.66042  1.000 46.34546 ? 170 ILE F HG23   1 
ATOM   1008 H  HD11   . ILE C 3 6  ? 10.42046  7.57129   -7.62276  1.000 38.28720 ? 170 ILE F HD11   1 
ATOM   1009 H  HD12   . ILE C 3 6  ? 9.50184   8.61268   -8.39422  1.000 38.28720 ? 170 ILE F HD12   1 
ATOM   1010 H  HD13   . ILE C 3 6  ? 9.36612   8.44744   -6.82012  1.000 38.28720 ? 170 ILE F HD13   1 
ATOM   1011 N  N      . ARG C 3 7  ? 6.72467   4.29432   -7.47625  1.000 16.04491 ? 171 ARG F N      1 
ATOM   1012 C  CA     . ARG C 3 7  ? 6.68281   3.28944   -6.42424  1.000 13.94151 ? 171 ARG F CA     1 
ATOM   1013 C  C      . ARG C 3 7  ? 7.55339   3.71825   -5.25683  1.000 13.00198 ? 171 ARG F C      1 
ATOM   1014 O  O      . ARG C 3 7  ? 8.52505   4.46017   -5.42235  1.000 13.69825 ? 171 ARG F O      1 
ATOM   1015 C  CB     . ARG C 3 7  ? 7.13088   1.92949   -6.95900  1.000 14.29545 ? 171 ARG F CB     1 
ATOM   1016 C  CG     . ARG C 3 7  ? 6.13778   1.42116   -8.00076  1.000 21.50096 ? 171 ARG F CG     1 
ATOM   1017 C  CD     . ARG C 3 7  ? 6.39174   -0.00770  -8.39659  1.000 26.98252 ? 171 ARG F CD     1 
ATOM   1018 N  NE     . ARG C 3 7  ? 6.11114   -0.93763  -7.31550  1.000 18.42899 ? 171 ARG F NE     1 
ATOM   1019 C  CZ     . ARG C 3 7  ? 6.14442   -2.25222  -7.44210  1.000 18.55089 ? 171 ARG F CZ     1 
ATOM   1020 N  NH1    . ARG C 3 7  ? 6.47918   -2.82870  -8.58802  1.000 23.44483 ? 171 ARG F NH1    1 
ATOM   1021 N  NH2    . ARG C 3 7  ? 5.82333   -3.00669  -6.40244  1.000 20.47338 ? 171 ARG F NH2    1 
ATOM   1022 H  H      . ARG C 3 7  ? 7.27941   4.12209   -8.11044  1.000 19.25389 ? 171 ARG F H      1 
ATOM   1023 H  HA     . ARG C 3 7  ? 5.77397   3.18768   -6.10090  1.000 16.72981 ? 171 ARG F HA     1 
ATOM   1024 H  HB2    . ARG C 3 7  ? 8.00279   2.01450   -7.37546  1.000 17.15454 ? 171 ARG F HB2    1 
ATOM   1025 H  HB3    . ARG C 3 7  ? 7.17213   1.29054   -6.23034  1.000 17.15454 ? 171 ARG F HB3    1 
ATOM   1026 H  HG2    . ARG C 3 7  ? 5.24053   1.47626   -7.63632  1.000 25.80116 ? 171 ARG F HG2    1 
ATOM   1027 H  HG3    . ARG C 3 7  ? 6.20637   1.96970   -8.79782  1.000 25.80116 ? 171 ARG F HG3    1 
ATOM   1028 H  HD2    . ARG C 3 7  ? 5.82091   -0.23614  -9.14684  1.000 32.37902 ? 171 ARG F HD2    1 
ATOM   1029 H  HD3    . ARG C 3 7  ? 7.32370   -0.10770  -8.64630  1.000 32.37902 ? 171 ARG F HD3    1 
ATOM   1030 H  HE     . ARG C 3 7  ? 5.91092   -0.61176  -6.54523  1.000 22.11479 ? 171 ARG F HE     1 
ATOM   1031 H  HH11   . ARG C 3 7  ? 6.68083   -2.34500  -9.26991  1.000 28.13380 ? 171 ARG F HH11   1 
ATOM   1032 H  HH12   . ARG C 3 7  ? 6.49469   -3.68636  -8.64950  1.000 28.13380 ? 171 ARG F HH12   1 
ATOM   1033 H  HH21   . ARG C 3 7  ? 5.59725   -2.63967  -5.65828  1.000 24.56805 ? 171 ARG F HH21   1 
ATOM   1034 H  HH22   . ARG C 3 7  ? 5.84086   -3.86375  -6.47134  1.000 24.56805 ? 171 ARG F HH22   1 
ATOM   1035 N  N      . LEU C 3 8  ? 7.19145   3.23933   -4.06141  1.000 10.88418 ? 172 LEU F N      1 
ATOM   1036 C  CA     . LEU C 3 8  ? 7.90628   3.64257   -2.85578  1.000 9.76899  ? 172 LEU F CA     1 
ATOM   1037 C  C      . LEU C 3 8  ? 9.39151   3.32413   -2.95147  1.000 12.24390 ? 172 LEU F C      1 
ATOM   1038 O  O      . LEU C 3 8  ? 10.23005  4.16492   -2.61900  1.000 12.63915 ? 172 LEU F O      1 
ATOM   1039 C  CB     . LEU C 3 8  ? 7.28323   2.98721   -1.61579  1.000 10.93505 ? 172 LEU F CB     1 
ATOM   1040 C  CG     . LEU C 3 8  ? 8.04363   3.16065   -0.29431  1.000 10.80976 ? 172 LEU F CG     1 
ATOM   1041 C  CD1    . LEU C 3 8  ? 8.24013   4.61075   0.04972   1.000 12.01086 ? 172 LEU F CD1    1 
ATOM   1042 C  CD2    . LEU C 3 8  ? 7.31040   2.41010   0.79896   1.000 10.19298 ? 172 LEU F CD2    1 
ATOM   1043 H  H      . LEU C 3 8  ? 6.54497   2.68831   -3.92706  1.000 13.06102 ? 172 LEU F H      1 
ATOM   1044 H  HA     . LEU C 3 8  ? 7.81654   4.60347   -2.75816  1.000 11.72279 ? 172 LEU F HA     1 
ATOM   1045 H  HB2    . LEU C 3 8  ? 6.39946   3.36600   -1.48789  1.000 13.12206 ? 172 LEU F HB2    1 
ATOM   1046 H  HB3    . LEU C 3 8  ? 7.21475   2.03405   -1.78220  1.000 13.12206 ? 172 LEU F HB3    1 
ATOM   1047 H  HG     . LEU C 3 8  ? 8.93587   2.78949   -0.37830  1.000 12.97171 ? 172 LEU F HG     1 
ATOM   1048 H  HD11   . LEU C 3 8  ? 8.74114   4.67375   0.87792   1.000 14.41303 ? 172 LEU F HD11   1 
ATOM   1049 H  HD12   . LEU C 3 8  ? 8.73095   5.04174   -0.66739  1.000 14.41303 ? 172 LEU F HD12   1 
ATOM   1050 H  HD13   . LEU C 3 8  ? 7.37215   5.03067   0.15543   1.000 14.41303 ? 172 LEU F HD13   1 
ATOM   1051 H  HD21   . LEU C 3 8  ? 7.75247   2.57512   1.64645   1.000 12.23158 ? 172 LEU F HD21   1 
ATOM   1052 H  HD22   . LEU C 3 8  ? 6.39351   2.72431   0.83745   1.000 12.23158 ? 172 LEU F HD22   1 
ATOM   1053 H  HD23   . LEU C 3 8  ? 7.32679   1.46160   0.59650   1.000 12.23158 ? 172 LEU F HD23   1 
ATOM   1054 N  N      . TYR C 3 9  ? 9.75814   2.12328   -3.40588  1.000 11.96623 ? 173 TYR F N      1 
ATOM   1055 C  CA     . TYR C 3 9  ? 11.19852  1.83617   -3.44212  1.000 12.48497 ? 173 TYR F CA     1 
ATOM   1056 C  C      . TYR C 3 9  ? 11.92073  2.78294   -4.38816  1.000 14.42901 ? 173 TYR F C      1 
ATOM   1057 O  O      . TYR C 3 9  ? 13.07386  3.16322   -4.13443  1.000 13.27889 ? 173 TYR F O      1 
ATOM   1058 C  CB     . TYR C 3 9  ? 11.46985  0.37900   -3.83358  1.000 13.72968 ? 173 TYR F CB     1 
ATOM   1059 C  CG     . TYR C 3 9  ? 11.17022  0.00827   -5.26912  1.000 13.43919 ? 173 TYR F CG     1 
ATOM   1060 C  CD1    . TYR C 3 9  ? 12.05882  0.31916   -6.28917  1.000 14.04603 ? 173 TYR F CD1    1 
ATOM   1061 C  CD2    . TYR C 3 9  ? 10.01672  -0.67477  -5.59124  1.000 12.95496 ? 173 TYR F CD2    1 
ATOM   1062 C  CE1    . TYR C 3 9  ? 11.80159  -0.03498  -7.59871  1.000 14.79901 ? 173 TYR F CE1    1 
ATOM   1063 C  CE2    . TYR C 3 9  ? 9.75310   -1.05208  -6.89571  1.000 19.88040 ? 173 TYR F CE2    1 
ATOM   1064 C  CZ     . TYR C 3 9  ? 10.65676  -0.72517  -7.89604  1.000 19.16176 ? 173 TYR F CZ     1 
ATOM   1065 O  OH     . TYR C 3 9  ? 10.40311  -1.08008  -9.19734  1.000 25.84131 ? 173 TYR F OH     1 
ATOM   1066 H  H      . TYR C 3 9  ? 9.23288   1.49996   -3.68005  1.000 14.35948 ? 173 TYR F H      1 
ATOM   1067 H  HA     . TYR C 3 9  ? 11.55419  1.95671   -2.54777  1.000 14.98196 ? 173 TYR F HA     1 
ATOM   1068 H  HB2    . TYR C 3 9  ? 12.40983  0.19459   -3.68087  1.000 16.47562 ? 173 TYR F HB2    1 
ATOM   1069 H  HB3    . TYR C 3 9  ? 10.92400  -0.19222  -3.27085  1.000 16.47562 ? 173 TYR F HB3    1 
ATOM   1070 H  HD1    . TYR C 3 9  ? 12.84349  0.77533   -6.08641  1.000 16.85524 ? 173 TYR F HD1    1 
ATOM   1071 H  HD2    . TYR C 3 9  ? 9.40671   -0.88499  -4.92147  1.000 15.54595 ? 173 TYR F HD2    1 
ATOM   1072 H  HE1    . TYR C 3 9  ? 12.40038  0.19314   -8.27273  1.000 17.75881 ? 173 TYR F HE1    1 
ATOM   1073 H  HE2    . TYR C 3 9  ? 8.97649   -1.52102  -7.10034  1.000 23.85649 ? 173 TYR F HE2    1 
ATOM   1074 H  HH     . TYR C 3 9  ? 9.71283   -1.55719  -9.23568  1.000 31.00958 ? 173 TYR F HH     1 
ATOM   1075 N  N      . GLN C 3 10 ? 11.25857  3.20189   -5.46535  1.000 12.17374 ? 174 GLN F N      1 
ATOM   1076 C  CA     . GLN C 3 10 ? 11.91173  4.09426   -6.42128  1.000 14.18770 ? 174 GLN F CA     1 
ATOM   1077 C  C      . GLN C 3 10 ? 12.02999  5.50910   -5.86673  1.000 14.31750 ? 174 GLN F C      1 
ATOM   1078 O  O      . GLN C 3 10 ? 13.03608  6.18812   -6.09807  1.000 14.91089 ? 174 GLN F O      1 
ATOM   1079 C  CB     . GLN C 3 10 ? 11.15688  4.11536   -7.75244  1.000 15.32549 ? 174 GLN F CB     1 
ATOM   1080 C  CG     . GLN C 3 10 ? 11.94492  4.79501   -8.85733  1.000 20.21640 ? 174 GLN F CG     1 
ATOM   1081 C  CD     . GLN C 3 10 ? 13.19136  4.03823   -9.26478  1.000 22.74685 ? 174 GLN F CD     1 
ATOM   1082 O  OE1    . GLN C 3 10 ? 13.15511  2.82964   -9.47799  1.000 23.46130 ? 174 GLN F OE1    1 
ATOM   1083 N  NE2    . GLN C 3 10 ? 14.30475  4.75822   -9.40386  1.000 21.24061 ? 174 GLN F NE2    1 
ATOM   1084 H  H      . GLN C 3 10 ? 10.44882  2.98964   -5.66245  1.000 14.60849 ? 174 GLN F H      1 
ATOM   1085 H  HA     . GLN C 3 10 ? 12.80310  3.75090   -6.59003  1.000 17.02523 ? 174 GLN F HA     1 
ATOM   1086 H  HB2    . GLN C 3 10 ? 10.97633  3.20314   -8.02841  1.000 18.39059 ? 174 GLN F HB2    1 
ATOM   1087 H  HB3    . GLN C 3 10 ? 10.32348  4.59787   -7.63609  1.000 18.39059 ? 174 GLN F HB3    1 
ATOM   1088 H  HG2    . GLN C 3 10 ? 11.37866  4.87739   -9.64057  1.000 24.25968 ? 174 GLN F HG2    1 
ATOM   1089 H  HG3    . GLN C 3 10 ? 12.21831  5.67405   -8.55165  1.000 24.25968 ? 174 GLN F HG3    1 
ATOM   1090 H  HE21   . GLN C 3 10 ? 14.28859  5.60653   -9.26350  1.000 25.48873 ? 174 GLN F HE21   1 
ATOM   1091 H  HE22   . GLN C 3 10 ? 15.03912  4.37435   -9.63393  1.000 25.48873 ? 174 GLN F HE22   1 
ATOM   1092 N  N      . PHE C 3 11 ? 11.01098  5.96471   -5.13210  1.000 11.29479 ? 175 PHE F N      1 
ATOM   1093 C  CA     . PHE C 3 11 ? 11.08482  7.23268   -4.40692  1.000 12.72951 ? 175 PHE F CA     1 
ATOM   1094 C  C      . PHE C 3 11 ? 12.30822  7.28865   -3.49443  1.000 14.22795 ? 175 PHE F C      1 
ATOM   1095 O  O      . PHE C 3 11 ? 13.04241  8.29122   -3.46200  1.000 14.56385 ? 175 PHE F O      1 
ATOM   1096 C  CB     . PHE C 3 11 ? 9.79392   7.39399   -3.59848  1.000 13.13811 ? 175 PHE F CB     1 
ATOM   1097 C  CG     . PHE C 3 11 ? 9.81177   8.51953   -2.60511  1.000 17.80761 ? 175 PHE F CG     1 
ATOM   1098 C  CD1    . PHE C 3 11 ? 9.47239   9.80766   -2.97855  1.000 16.13944 ? 175 PHE F CD1    1 
ATOM   1099 C  CD2    . PHE C 3 11 ? 10.10143  8.26724   -1.27677  1.000 14.33473 ? 175 PHE F CD2    1 
ATOM   1100 C  CE1    . PHE C 3 11 ? 9.46491   10.82123  -2.04540  1.000 17.02806 ? 175 PHE F CE1    1 
ATOM   1101 C  CE2    . PHE C 3 11 ? 10.10136  9.27234   -0.34478  1.000 18.47379 ? 175 PHE F CE2    1 
ATOM   1102 C  CZ     . PHE C 3 11 ? 9.78165   10.54884  -0.72339  1.000 15.11493 ? 175 PHE F CZ     1 
ATOM   1103 H  H      . PHE C 3 11 ? 10.26075  5.55519   -5.03698  1.000 13.55375 ? 175 PHE F H      1 
ATOM   1104 H  HA     . PHE C 3 11 ? 11.16604  7.96718   -5.03526  1.000 15.27541 ? 175 PHE F HA     1 
ATOM   1105 H  HB2    . PHE C 3 11 ? 9.06324   7.55986   -4.21451  1.000 15.76573 ? 175 PHE F HB2    1 
ATOM   1106 H  HB3    . PHE C 3 11 ? 9.63360   6.57328   -3.10691  1.000 15.76573 ? 175 PHE F HB3    1 
ATOM   1107 H  HD1    . PHE C 3 11 ? 9.24851   9.99004   -3.86259  1.000 19.36733 ? 175 PHE F HD1    1 
ATOM   1108 H  HD2    . PHE C 3 11 ? 10.30019  7.39862   -1.01051  1.000 17.20167 ? 175 PHE F HD2    1 
ATOM   1109 H  HE1    . PHE C 3 11 ? 9.24739   11.68817  -2.30229  1.000 20.43367 ? 175 PHE F HE1    1 
ATOM   1110 H  HE2    . PHE C 3 11 ? 10.31750  9.08814   0.54080   1.000 22.16855 ? 175 PHE F HE2    1 
ATOM   1111 H  HZ     . PHE C 3 11 ? 9.77698   11.23319  -0.09367  1.000 18.13792 ? 175 PHE F HZ     1 
ATOM   1112 N  N      . LEU C 3 12 ? 12.54207  6.21267   -2.74105  1.000 13.11572 ? 176 LEU F N      1 
ATOM   1113 C  CA     . LEU C 3 12 ? 13.67638  6.18349   -1.82583  1.000 12.15214 ? 176 LEU F CA     1 
ATOM   1114 C  C      . LEU C 3 12 ? 14.99032  6.16458   -2.58369  1.000 12.57684 ? 176 LEU F C      1 
ATOM   1115 O  O      . LEU C 3 12 ? 15.94704  6.84279   -2.18847  1.000 11.68424 ? 176 LEU F O      1 
ATOM   1116 C  CB     . LEU C 3 12 ? 13.61010  4.96225   -0.91556  1.000 11.48244 ? 176 LEU F CB     1 
ATOM   1117 C  CG     . LEU C 3 12 ? 12.36834  4.92684   -0.01750  1.000 11.15819 ? 176 LEU F CG     1 
ATOM   1118 C  CD1    . LEU C 3 12 ? 12.22743  3.63839   0.73393   1.000 11.71642 ? 176 LEU F CD1    1 
ATOM   1119 C  CD2    . LEU C 3 12 ? 12.39547  6.06827   0.94474   1.000 12.09009 ? 176 LEU F CD2    1 
ATOM   1120 H  H      . LEU C 3 12 ? 12.06462  5.49738   -2.74230  1.000 15.73886 ? 176 LEU F H      1 
ATOM   1121 H  HA     . LEU C 3 12 ? 13.63216  6.98055   -1.27480  1.000 14.58257 ? 176 LEU F HA     1 
ATOM   1122 H  HB2    . LEU C 3 12 ? 13.60061  4.16390   -1.46643  1.000 13.77893 ? 176 LEU F HB2    1 
ATOM   1123 H  HB3    . LEU C 3 12 ? 14.39174  4.95971   -0.34116  1.000 13.77893 ? 176 LEU F HB3    1 
ATOM   1124 H  HG     . LEU C 3 12 ? 11.59335  5.00223   -0.59595  1.000 13.38983 ? 176 LEU F HG     1 
ATOM   1125 H  HD11   . LEU C 3 12 ? 11.43060  3.68001   1.28551   1.000 14.05971 ? 176 LEU F HD11   1 
ATOM   1126 H  HD12   . LEU C 3 12 ? 12.15240  2.90902   0.09887   1.000 14.05971 ? 176 LEU F HD12   1 
ATOM   1127 H  HD13   . LEU C 3 12 ? 13.01017  3.51138   1.29257   1.000 14.05971 ? 176 LEU F HD13   1 
ATOM   1128 H  HD21   . LEU C 3 12 ? 11.65511  5.97636   1.56468   1.000 14.50811 ? 176 LEU F HD21   1 
ATOM   1129 H  HD22   . LEU C 3 12 ? 13.23596  6.05339   1.42873   1.000 14.50811 ? 176 LEU F HD22   1 
ATOM   1130 H  HD23   . LEU C 3 12 ? 12.31255  6.89928   0.45135   1.000 14.50811 ? 176 LEU F HD23   1 
ATOM   1131 N  N      . LEU C 3 13 ? 15.06952  5.34274   -3.63494  1.000 12.33337 ? 177 LEU F N      1 
ATOM   1132 C  CA     . LEU C 3 13 ? 16.28951  5.28250   -4.42556  1.000 13.33246 ? 177 LEU F CA     1 
ATOM   1133 C  C      . LEU C 3 13 ? 16.58827  6.62749   -5.06497  1.000 13.66715 ? 177 LEU F C      1 
ATOM   1134 O  O      . LEU C 3 13 ? 17.72847  7.11137   -5.02031  1.000 14.47924 ? 177 LEU F O      1 
ATOM   1135 C  CB     . LEU C 3 13 ? 16.15674  4.18349   -5.47256  1.000 12.71019 ? 177 LEU F CB     1 
ATOM   1136 C  CG     . LEU C 3 13 ? 17.35048  3.96274   -6.39685  1.000 13.80638 ? 177 LEU F CG     1 
ATOM   1137 C  CD1    . LEU C 3 13 ? 18.61651  3.71862   -5.59354  1.000 13.84736 ? 177 LEU F CD1    1 
ATOM   1138 C  CD2    . LEU C 3 13 ? 17.06887  2.80123   -7.35567  1.000 15.17390 ? 177 LEU F CD2    1 
ATOM   1139 H  H      . LEU C 3 13 ? 14.44031  4.82121   -3.90273  1.000 14.80004 ? 177 LEU F H      1 
ATOM   1140 H  HA     . LEU C 3 13 ? 17.04176  5.06007   -3.85499  1.000 15.99895 ? 177 LEU F HA     1 
ATOM   1141 H  HB2    . LEU C 3 13 ? 15.99896  3.34632   -5.00871  1.000 15.25222 ? 177 LEU F HB2    1 
ATOM   1142 H  HB3    . LEU C 3 13 ? 15.39752  4.39837   -6.03675  1.000 15.25222 ? 177 LEU F HB3    1 
ATOM   1143 H  HG     . LEU C 3 13 ? 17.49585  4.76075   -6.92877  1.000 16.56765 ? 177 LEU F HG     1 
ATOM   1144 H  HD11   . LEU C 3 13 ? 19.33699  3.48980   -6.20136  1.000 16.61683 ? 177 LEU F HD11   1 
ATOM   1145 H  HD12   . LEU C 3 13 ? 18.84042  4.52555   -5.10402  1.000 16.61683 ? 177 LEU F HD12   1 
ATOM   1146 H  HD13   . LEU C 3 13 ? 18.46167  2.98828   -4.97425  1.000 16.61683 ? 177 LEU F HD13   1 
ATOM   1147 H  HD21   . LEU C 3 13 ? 17.85160  2.65131   -7.90862  1.000 18.20868 ? 177 LEU F HD21   1 
ATOM   1148 H  HD22   . LEU C 3 13 ? 16.87219  2.00491   -6.83791  1.000 18.20868 ? 177 LEU F HD22   1 
ATOM   1149 H  HD23   . LEU C 3 13 ? 16.30868  3.02931   -7.91335  1.000 18.20868 ? 177 LEU F HD23   1 
ATOM   1150 N  N      . ASP C 3 14 ? 15.55924  7.27852   -5.60485  1.000 14.15503 ? 178 ASP F N      1 
ATOM   1151 C  CA     . ASP C 3 14 ? 15.73689  8.60144   -6.18279  1.000 15.64288 ? 178 ASP F CA     1 
ATOM   1152 C  C      . ASP C 3 14 ? 16.23864  9.59749   -5.14666  1.000 16.22063 ? 178 ASP F C      1 
ATOM   1153 O  O      . ASP C 3 14 ? 17.09167  10.44176  -5.44985  1.000 17.98734 ? 178 ASP F O      1 
ATOM   1154 C  CB     . ASP C 3 14 ? 14.41536  9.09685   -6.78148  1.000 17.22373 ? 178 ASP F CB     1 
ATOM   1155 C  CG     . ASP C 3 14 ? 13.98140  8.32572   -8.03114  1.000 23.41539 ? 178 ASP F CG     1 
ATOM   1156 O  OD1    . ASP C 3 14 ? 14.75889  7.52934   -8.58418  1.000 20.95009 ? 178 ASP F OD1    1 
ATOM   1157 O  OD2    . ASP C 3 14 ? 12.83416  8.55286   -8.47925  1.000 26.67922 ? 178 ASP F OD2    1 
ATOM   1158 H  H      . ASP C 3 14 ? 14.75508  6.97673   -5.64774  1.000 16.98604 ? 178 ASP F H      1 
ATOM   1159 H  HA     . ASP C 3 14 ? 16.39467  8.53906   -6.89296  1.000 18.77145 ? 178 ASP F HA     1 
ATOM   1160 H  HB2    . ASP C 3 14 ? 13.71553  9.00169   -6.11659  1.000 20.66847 ? 178 ASP F HB2    1 
ATOM   1161 H  HB3    . ASP C 3 14 ? 14.51392  10.02975  -7.02823  1.000 20.66847 ? 178 ASP F HB3    1 
ATOM   1162 N  N      . LEU C 3 15 ? 15.68167  9.55936   -3.93128  1.000 12.47851 ? 179 LEU F N      1 
ATOM   1163 C  CA     . LEU C 3 15 ? 16.18271  10.43054  -2.86957  1.000 13.52622 ? 179 LEU F CA     1 
ATOM   1164 C  C      . LEU C 3 15 ? 17.65381  10.16871  -2.60412  1.000 16.02416 ? 179 LEU F C      1 
ATOM   1165 O  O      . LEU C 3 15 ? 18.45923  11.09787  -2.48989  1.000 16.61318 ? 179 LEU F O      1 
ATOM   1166 C  CB     . LEU C 3 15 ? 15.38902  10.22830  -1.57796  1.000 18.59063 ? 179 LEU F CB     1 
ATOM   1167 C  CG     . LEU C 3 15 ? 14.09361  11.00033  -1.43454  1.000 25.56767 ? 179 LEU F CG     1 
ATOM   1168 C  CD1    . LEU C 3 15 ? 13.51181  10.71806  -0.06541  1.000 23.60447 ? 179 LEU F CD1    1 
ATOM   1169 C  CD2    . LEU C 3 15 ? 14.34897  12.49166  -1.62496  1.000 25.23266 ? 179 LEU F CD2    1 
ATOM   1170 H  H      . LEU C 3 15 ? 15.02796  9.04944   -3.70270  1.000 14.97421 ? 179 LEU F H      1 
ATOM   1171 H  HA     . LEU C 3 15 ? 16.06605  11.34934  -3.15782  1.000 16.23146 ? 179 LEU F HA     1 
ATOM   1172 H  HB2    . LEU C 3 15 ? 15.16548  9.28686   -1.51005  1.000 22.30875 ? 179 LEU F HB2    1 
ATOM   1173 H  HB3    . LEU C 3 15 ? 15.95653  10.48892  -0.83573  1.000 22.30875 ? 179 LEU F HB3    1 
ATOM   1174 H  HG     . LEU C 3 15 ? 13.45390  10.72680  -2.11045  1.000 30.68121 ? 179 LEU F HG     1 
ATOM   1175 H  HD11   . LEU C 3 15 ? 12.67925  11.20641  0.03074   1.000 28.32537 ? 179 LEU F HD11   1 
ATOM   1176 H  HD12   . LEU C 3 15 ? 13.34814  9.76560   0.01793   1.000 28.32537 ? 179 LEU F HD12   1 
ATOM   1177 H  HD13   . LEU C 3 15 ? 14.14402  11.00554  0.61177   1.000 28.32537 ? 179 LEU F HD13   1 
ATOM   1178 H  HD21   . LEU C 3 15 ? 13.61376  12.99022  -1.23536  1.000 30.27920 ? 179 LEU F HD21   1 
ATOM   1179 H  HD22   . LEU C 3 15 ? 15.17978  12.72864  -1.18395  1.000 30.27920 ? 179 LEU F HD22   1 
ATOM   1180 H  HD23   . LEU C 3 15 ? 14.41202  12.68262  -2.57389  1.000 30.27920 ? 179 LEU F HD23   1 
ATOM   1181 N  N      . LEU C 3 16 ? 18.02066  8.90302   -2.48301  1.000 14.47134 ? 180 LEU F N      1 
ATOM   1182 C  CA     . LEU C 3 16 ? 19.41054  8.58590   -2.19711  1.000 15.41393 ? 180 LEU F CA     1 
ATOM   1183 C  C      . LEU C 3 16 ? 20.32481  9.07562   -3.30540  1.000 15.56677 ? 180 LEU F C      1 
ATOM   1184 O  O      . LEU C 3 16 ? 21.42884  9.55303   -3.04097  1.000 20.01203 ? 180 LEU F O      1 
ATOM   1185 C  CB     . LEU C 3 16 ? 19.55581  7.09083   -2.00100  1.000 13.32878 ? 180 LEU F CB     1 
ATOM   1186 C  CG     . LEU C 3 16 ? 19.11765  6.64606   -0.60313  1.000 13.34473 ? 180 LEU F CG     1 
ATOM   1187 C  CD1    . LEU C 3 16 ? 18.76697  5.16291   -0.63310  1.000 14.57466 ? 180 LEU F CD1    1 
ATOM   1188 C  CD2    . LEU C 3 16 ? 20.18587  6.94779   0.45181   1.000 14.55981 ? 180 LEU F CD2    1 
ATOM   1189 H  H      . LEU C 3 16 ? 17.49829  8.22416   -2.55964  1.000 17.36561 ? 180 LEU F H      1 
ATOM   1190 H  HA     . LEU C 3 16 ? 19.67886  9.02878   -1.37689  1.000 18.49671 ? 180 LEU F HA     1 
ATOM   1191 H  HB2    . LEU C 3 16 ? 19.00440  6.63029   -2.65272  1.000 15.99454 ? 180 LEU F HB2    1 
ATOM   1192 H  HB3    . LEU C 3 16 ? 20.48631  6.84414   -2.12018  1.000 15.99454 ? 180 LEU F HB3    1 
ATOM   1193 H  HG     . LEU C 3 16 ? 18.33050  7.14800   -0.33979  1.000 16.01368 ? 180 LEU F HG     1 
ATOM   1194 H  HD11   . LEU C 3 16 ? 18.54493  4.87268   0.26544   1.000 17.48959 ? 180 LEU F HD11   1 
ATOM   1195 H  HD12   . LEU C 3 16 ? 18.00693  5.02992   -1.22094  1.000 17.48959 ? 180 LEU F HD12   1 
ATOM   1196 H  HD13   . LEU C 3 16 ? 19.53107  4.66432   -0.96241  1.000 17.48959 ? 180 LEU F HD13   1 
ATOM   1197 H  HD21   . LEU C 3 16 ? 19.88937  6.60367   1.30888   1.000 17.47177 ? 180 LEU F HD21   1 
ATOM   1198 H  HD22   . LEU C 3 16 ? 21.01611  6.51852   0.19232   1.000 17.47177 ? 180 LEU F HD22   1 
ATOM   1199 H  HD23   . LEU C 3 16 ? 20.31302  7.90784   0.50690   1.000 17.47177 ? 180 LEU F HD23   1 
ATOM   1200 N  N      . ARG C 3 17 ? 19.88714  8.96490   -4.55219  1.000 16.97480 ? 181 ARG F N      1 
ATOM   1201 C  CA     . ARG C 3 17 ? 20.71221  9.43050   -5.66110  1.000 17.60349 ? 181 ARG F CA     1 
ATOM   1202 C  C      . ARG C 3 17 ? 20.81719  10.94789  -5.67937  1.000 27.72354 ? 181 ARG F C      1 
ATOM   1203 O  O      . ARG C 3 17 ? 21.88215  11.49826  -5.98944  1.000 25.04070 ? 181 ARG F O      1 
ATOM   1204 C  CB     . ARG C 3 17 ? 20.14145  8.91709   -6.97428  1.000 18.37978 ? 181 ARG F CB     1 
ATOM   1205 C  CG     . ARG C 3 17 ? 20.35445  7.43571   -7.17402  1.000 20.16271 ? 181 ARG F CG     1 
ATOM   1206 C  CD     . ARG C 3 17 ? 20.03611  7.03569   -8.58900  1.000 33.12624 ? 181 ARG F CD     1 
ATOM   1207 N  NE     . ARG C 3 17 ? 20.41795  5.65607   -8.84666  1.000 26.39641 ? 181 ARG F NE     1 
ATOM   1208 C  CZ     . ARG C 3 17 ? 19.65097  4.75043   -9.43316  1.000 18.98949 ? 181 ARG F CZ     1 
ATOM   1209 N  NH1    . ARG C 3 17 ? 18.43191  5.04451   -9.85916  1.000 22.66910 ? 181 ARG F NH1    1 
ATOM   1210 N  NH2    . ARG C 3 17 ? 20.13001  3.52475   -9.61889  1.000 22.32301 ? 181 ARG F NH2    1 
ATOM   1211 H  H      . ARG C 3 17 ? 19.12916  8.62988   -4.78202  1.000 20.36976 ? 181 ARG F H      1 
ATOM   1212 H  HA     . ARG C 3 17 ? 21.60843  9.07429   -5.55711  1.000 21.12419 ? 181 ARG F HA     1 
ATOM   1213 H  HB2    . ARG C 3 17 ? 19.18648  9.08650   -6.98952  1.000 22.05573 ? 181 ARG F HB2    1 
ATOM   1214 H  HB3    . ARG C 3 17 ? 20.57273  9.38268   -7.70785  1.000 22.05573 ? 181 ARG F HB3    1 
ATOM   1215 H  HG2    . ARG C 3 17 ? 21.28133  7.21443   -6.99281  1.000 24.19525 ? 181 ARG F HG2    1 
ATOM   1216 H  HG3    . ARG C 3 17 ? 19.77231  6.94126   -6.57609  1.000 24.19525 ? 181 ARG F HG3    1 
ATOM   1217 H  HD2    . ARG C 3 17 ? 19.08206  7.12255   -8.74113  1.000 39.75149 ? 181 ARG F HD2    1 
ATOM   1218 H  HD3    . ARG C 3 17 ? 20.52332  7.60763   -9.20252  1.000 39.75149 ? 181 ARG F HD3    1 
ATOM   1219 H  HE     . ARG C 3 17 ? 21.20356  5.40935   -8.59855  1.000 31.67570 ? 181 ARG F HE     1 
ATOM   1220 H  HH11   . ARG C 3 17 ? 18.12107  5.83989   -9.75742  1.000 27.20292 ? 181 ARG F HH11   1 
ATOM   1221 H  HH12   . ARG C 3 17 ? 17.95115  4.44009   -10.23751 1.000 27.20292 ? 181 ARG F HH12   1 
ATOM   1222 H  HH21   . ARG C 3 17 ? 20.92662  3.33054   -9.35947  1.000 26.78761 ? 181 ARG F HH21   1 
ATOM   1223 H  HH22   . ARG C 3 17 ? 19.64339  2.92584   -9.99850  1.000 26.78761 ? 181 ARG F HH22   1 
ATOM   1224 N  N      . SER C 3 18 ? 19.72086  11.64221  -5.36493  1.000 21.63067 ? 182 SER F N      1 
ATOM   1225 C  CA     . SER C 3 18 ? 19.71153  13.09666  -5.45531  1.000 23.22433 ? 182 SER F CA     1 
ATOM   1226 C  C      . SER C 3 18 ? 20.38323  13.75878  -4.25917  1.000 26.88647 ? 182 SER F C      1 
ATOM   1227 O  O      . SER C 3 18 ? 20.86514  14.89269  -4.37222  1.000 23.70732 ? 182 SER F O      1 
ATOM   1228 C  CB     . SER C 3 18 ? 18.27264  13.59279  -5.55877  1.000 26.36926 ? 182 SER F CB     1 
ATOM   1229 O  OG     . SER C 3 18 ? 17.64822  13.54776  -4.28649  1.000 25.45221 ? 182 SER F OG     1 
ATOM   1230 H  H      . SER C 3 18 ? 18.97952  11.29612  -5.09991  1.000 25.95681 ? 182 SER F H      1 
ATOM   1231 H  HA     . SER C 3 18 ? 20.19571  13.35741  -6.25436  1.000 27.86920 ? 182 SER F HA     1 
ATOM   1232 H  HB2    . SER C 3 18 ? 18.27349  14.50769  -5.88104  1.000 31.64311 ? 182 SER F HB2    1 
ATOM   1233 H  HB3    . SER C 3 18 ? 17.78324  13.02474  -6.17415  1.000 31.64311 ? 182 SER F HB3    1 
ATOM   1234 H  HG     . SER C 3 18 ? 17.62020  12.75573  -4.00808  1.000 30.54266 ? 182 SER F HG     1 
ATOM   1235 N  N      . GLY C 3 19 ? 20.39113  13.09625  -3.10675  1.000 21.79049 ? 183 GLY F N      1 
ATOM   1236 C  CA     . GLY C 3 19 ? 20.89396  13.69449  -1.88552  1.000 22.83874 ? 183 GLY F CA     1 
ATOM   1237 C  C      . GLY C 3 19 ? 20.00387  14.75071  -1.25788  1.000 28.03373 ? 183 GLY F C      1 
ATOM   1238 O  O      . GLY C 3 19 ? 20.43856  15.41790  -0.31322  1.000 25.16837 ? 183 GLY F O      1 
ATOM   1239 H  H      . GLY C 3 19 ? 20.10687  12.29054  -3.00864  1.000 26.14859 ? 183 GLY F H      1 
ATOM   1240 H  HA2    . GLY C 3 19 ? 21.02206  12.99202  -1.22900  1.000 27.40649 ? 183 GLY F HA2    1 
ATOM   1241 H  HA3    . GLY C 3 19 ? 21.75013  14.10880  -2.07585  1.000 27.40649 ? 183 GLY F HA3    1 
ATOM   1242 N  N      . ASP C 3 20 ? 18.75683  14.90497  -1.71172  1.000 25.91672 ? 184 ASP F N      1 
ATOM   1243 C  CA     . ASP C 3 20 ? 17.95712  16.05002  -1.27820  1.000 26.58278 ? 184 ASP F CA     1 
ATOM   1244 C  C      . ASP C 3 20 ? 17.54131  15.97902  0.18669   0.833 28.90574 ? 184 ASP F C      1 
ATOM   1245 O  O      . ASP C 3 20 ? 17.17796  17.01385  0.75806   0.918 25.84667 ? 184 ASP F O      1 
ATOM   1246 C  CB     . ASP C 3 20 ? 16.70642  16.19600  -2.13961  1.000 27.06397 ? 184 ASP F CB     1 
ATOM   1247 C  CG     . ASP C 3 20 ? 16.04633  17.55059  -1.96033  0.346 33.81741 ? 184 ASP F CG     1 
ATOM   1248 O  OD1    . ASP C 3 20 ? 16.72665  18.56686  -2.22060  0.683 34.27848 ? 184 ASP F OD1    1 
ATOM   1249 O  OD2    . ASP C 3 20 ? 14.86623  17.60654  -1.54448  0.563 36.21115 ? 184 ASP F OD2    1 
ATOM   1250 H  H      . ASP C 3 20 ? 18.36059  14.37253  -2.25863  1.000 31.10007 ? 184 ASP F H      1 
ATOM   1251 H  HA     . ASP C 3 20 ? 18.50691  16.84037  -1.39643  1.000 31.89933 ? 184 ASP F HA     1 
ATOM   1252 H  HB2    . ASP C 3 20 ? 16.94942  16.09863  -3.07362  1.000 32.47676 ? 184 ASP F HB2    1 
ATOM   1253 H  HB3    . ASP C 3 20 ? 16.06592  15.51150  -1.89035  1.000 32.47676 ? 184 ASP F HB3    1 
ATOM   1254 N  N      . MET C 3 21 ? 17.56101  14.79917  0.80483   1.000 20.04209 ? 185 MET F N      1 
ATOM   1255 C  CA     . MET C 3 21 ? 17.21489  14.64591  2.21660   1.000 18.16633 ? 185 MET F CA     1 
ATOM   1256 C  C      . MET C 3 21 ? 18.29553  13.85208  2.93552   1.000 19.91983 ? 185 MET F C      1 
ATOM   1257 O  O      . MET C 3 21 ? 18.02321  12.86585  3.62439   1.000 17.91029 ? 185 MET F O      1 
ATOM   1258 C  CB     . MET C 3 21 ? 15.86170  13.96459  2.40640   1.000 16.93484 ? 185 MET F CB     1 
ATOM   1259 C  CG     . MET C 3 21 ? 14.70448  14.72310  1.81291   1.000 23.36504 ? 185 MET F CG     1 
ATOM   1260 S  SD     . MET C 3 21 ? 13.11279  14.12249  2.39820   1.000 22.41746 ? 185 MET F SD     1 
ATOM   1261 C  CE     . MET C 3 21 ? 13.01299  14.90103  4.00014   1.000 17.69835 ? 185 MET F CE     1 
ATOM   1262 H  H      . MET C 3 21 ? 17.77550  14.06076  0.41969   1.000 24.05050 ? 185 MET F H      1 
ATOM   1263 H  HA     . MET C 3 21 ? 17.15711  15.53717  2.59504   1.000 21.79960 ? 185 MET F HA     1 
ATOM   1264 H  HB2    . MET C 3 21 ? 15.89089  13.09238  1.98296   1.000 20.32180 ? 185 MET F HB2    1 
ATOM   1265 H  HB3    . MET C 3 21 ? 15.69378  13.86656  3.35672   1.000 20.32180 ? 185 MET F HB3    1 
ATOM   1266 H  HG2    . MET C 3 21 ? 14.78086  15.65895  2.05629   1.000 28.03805 ? 185 MET F HG2    1 
ATOM   1267 H  HG3    . MET C 3 21 ? 14.72528  14.62854  0.84776   1.000 28.03805 ? 185 MET F HG3    1 
ATOM   1268 H  HE1    . MET C 3 21 ? 12.19233  14.62268  4.43596   1.000 21.23802 ? 185 MET F HE1    1 
ATOM   1269 H  HE2    . MET C 3 21 ? 13.77801  14.62984  4.53127   1.000 21.23802 ? 185 MET F HE2    1 
ATOM   1270 H  HE3    . MET C 3 21 ? 13.01562  15.86404  3.88395   1.000 21.23802 ? 185 MET F HE3    1 
ATOM   1271 N  N      . LYS C 3 22 ? 19.54848  14.30744  2.79054   1.000 23.06651 ? 186 LYS F N      1 
ATOM   1272 C  CA     . LYS C 3 22 ? 20.69192  13.56771  3.31414   1.000 23.69155 ? 186 LYS F CA     1 
ATOM   1273 C  C      . LYS C 3 22 ? 20.63398  13.41142  4.82458   1.000 18.79204 ? 186 LYS F C      1 
ATOM   1274 O  O      . LYS C 3 22 ? 21.28345  12.51756  5.37918   1.000 21.57817 ? 186 LYS F O      1 
ATOM   1275 C  CB     . LYS C 3 22 ? 22.00429  14.27226  2.93940   1.000 30.26241 ? 186 LYS F CB     1 
ATOM   1276 C  CG     . LYS C 3 22 ? 22.40083  14.18010  1.47769   1.000 46.37328 ? 186 LYS F CG     1 
ATOM   1277 C  CD     . LYS C 3 22 ? 23.91593  14.24180  1.29452   1.000 50.10100 ? 186 LYS F CD     1 
ATOM   1278 C  CE     . LYS C 3 22 ? 24.49659  12.87746  0.93851   1.000 67.21263 ? 186 LYS F CE     1 
ATOM   1279 N  NZ     . LYS C 3 22 ? 24.15488  12.45282  -0.46130  1.000 50.79414 ? 186 LYS F NZ     1 
ATOM   1280 H  H      . LYS C 3 22 ? 19.75764  15.04086  2.39311   1.000 27.67981 ? 186 LYS F H      1 
ATOM   1281 H  HA     . LYS C 3 22 ? 20.68860  12.68634  2.90909   1.000 28.42986 ? 186 LYS F HA     1 
ATOM   1282 H  HB2    . LYS C 3 22 ? 21.91775  15.21374  3.15623   1.000 36.31489 ? 186 LYS F HB2    1 
ATOM   1283 H  HB3    . LYS C 3 22 ? 22.72185  13.87681  3.45866   1.000 36.31489 ? 186 LYS F HB3    1 
ATOM   1284 H  HG2    . LYS C 3 22 ? 22.08522  13.33850  1.11301   1.000 55.64794 ? 186 LYS F HG2    1 
ATOM   1285 H  HG3    . LYS C 3 22 ? 22.00612  14.92105  0.99178   1.000 55.64794 ? 186 LYS F HG3    1 
ATOM   1286 H  HD2    . LYS C 3 22 ? 24.12718  14.85889  0.57656   1.000 60.12120 ? 186 LYS F HD2    1 
ATOM   1287 H  HD3    . LYS C 3 22 ? 24.32681  14.54091  2.12073   1.000 60.12120 ? 186 LYS F HD3    1 
ATOM   1288 H  HE2    . LYS C 3 22 ? 25.46294  12.91478  1.01377   1.000 80.65515 ? 186 LYS F HE2    1 
ATOM   1289 H  HE3    . LYS C 3 22 ? 24.14168  12.21271  1.54928   1.000 80.65515 ? 186 LYS F HE3    1 
ATOM   1290 H  HZ1    . LYS C 3 22 ? 23.27132  12.40988  -0.55925  1.000 60.95297 ? 186 LYS F HZ1    1 
ATOM   1291 H  HZ2    . LYS C 3 22 ? 24.50346  11.65148  -0.62996  1.000 60.95297 ? 186 LYS F HZ2    1 
ATOM   1292 H  HZ3    . LYS C 3 22 ? 24.48211  13.03895  -1.04566  1.000 60.95297 ? 186 LYS F HZ3    1 
ATOM   1293 N  N      . ASP C 3 23 ? 19.88467  14.26870  5.51428   1.000 16.02137 ? 187 ASP F N      1 
ATOM   1294 C  CA     . ASP C 3 23 ? 19.76911  14.16148  6.96170   1.000 16.40692 ? 187 ASP F CA     1 
ATOM   1295 C  C      . ASP C 3 23 ? 18.69790  13.17179  7.40178   1.000 15.57005 ? 187 ASP F C      1 
ATOM   1296 O  O      . ASP C 3 23 ? 18.59357  12.88606  8.59959   1.000 17.99732 ? 187 ASP F O      1 
ATOM   1297 C  CB     . ASP C 3 23 ? 19.45855  15.53433  7.55331   1.000 25.26489 ? 187 ASP F CB     1 
ATOM   1298 C  CG     . ASP C 3 23 ? 20.60108  16.51465  7.37532   1.000 35.92422 ? 187 ASP F CG     1 
ATOM   1299 O  OD1    . ASP C 3 23 ? 21.72204  16.07227  7.03516   1.000 31.88738 ? 187 ASP F OD1    1 
ATOM   1300 O  OD2    . ASP C 3 23 ? 20.37093  17.72634  7.57460   1.000 48.04183 ? 187 ASP F OD2    1 
ATOM   1301 H  H      . ASP C 3 23 ? 19.43720  14.91609  5.16749   1.000 19.22564 ? 187 ASP F H      1 
ATOM   1302 H  HA     . ASP C 3 23 ? 20.61762  13.85725  7.31999   1.000 19.68831 ? 187 ASP F HA     1 
ATOM   1303 H  HB2    . ASP C 3 23 ? 18.67630  15.90033  7.11169   1.000 30.31786 ? 187 ASP F HB2    1 
ATOM   1304 H  HB3    . ASP C 3 23 ? 19.28889  15.43909  8.50360   1.000 30.31786 ? 187 ASP F HB3    1 
ATOM   1305 N  N      . SER C 3 24 ? 17.90916  12.65477  6.46581   1.000 15.37361 ? 188 SER F N      1 
ATOM   1306 C  CA     . SER C 3 24 ? 16.84765  11.70354  6.75310   1.000 16.23799 ? 188 SER F CA     1 
ATOM   1307 C  C      . SER C 3 24 ? 17.16708  10.29403  6.29344   1.000 14.89740 ? 188 SER F C      1 
ATOM   1308 O  O      . SER C 3 24 ? 16.60220  9.33751   6.82973   1.000 13.43731 ? 188 SER F O      1 
ATOM   1309 C  CB     . SER C 3 24 ? 15.53743  12.13485  6.07268   1.000 14.52391 ? 188 SER F CB     1 
ATOM   1310 O  OG     . SER C 3 24 ? 15.06378  13.35254  6.60419   1.000 16.50492 ? 188 SER F OG     1 
ATOM   1311 H  H      . SER C 3 24 ? 17.97299  12.84710  5.63002   1.000 18.44833 ? 188 SER F H      1 
ATOM   1312 H  HA     . SER C 3 24 ? 16.69948  11.69168  7.71165   1.000 19.48559 ? 188 SER F HA     1 
ATOM   1313 H  HB2    . SER C 3 24 ? 15.69886  12.24804  5.12293   1.000 17.42870 ? 188 SER F HB2    1 
ATOM   1314 H  HB3    . SER C 3 24 ? 14.86786  11.44776  6.21582   1.000 17.42870 ? 188 SER F HB3    1 
ATOM   1315 H  HG     . SER C 3 24 ? 14.31814  13.54240  6.26718   1.000 19.80590 ? 188 SER F HG     1 
ATOM   1316 N  N      . ILE C 3 25 ? 18.02299  10.14287  5.28953   1.000 13.47468 ? 189 ILE F N      1 
ATOM   1317 C  CA     . ILE C 3 25 ? 18.29542  8.82966   4.72591   1.000 15.39202 ? 189 ILE F CA     1 
ATOM   1318 C  C      . ILE C 3 25 ? 19.68079  8.86477   4.11507   1.000 14.41946 ? 189 ILE F C      1 
ATOM   1319 O  O      . ILE C 3 25 ? 20.10526  9.89992   3.59179   1.000 15.16304 ? 189 ILE F O      1 
ATOM   1320 C  CB     . ILE C 3 25 ? 17.22856  8.46672   3.67439   1.000 10.06668 ? 189 ILE F CB     1 
ATOM   1321 C  CG1    . ILE C 3 25 ? 17.31529  6.99170   3.28633   1.000 11.71888 ? 189 ILE F CG1    1 
ATOM   1322 C  CG2    . ILE C 3 25 ? 17.35062  9.35264   2.44943   1.000 12.98535 ? 189 ILE F CG2    1 
ATOM   1323 C  CD1    . ILE C 3 25 ? 16.22493  6.56531   2.31686   1.000 14.19895 ? 189 ILE F CD1    1 
ATOM   1324 H  H      . ILE C 3 25 ? 18.45736  10.78598  4.91893   1.000 16.16962 ? 189 ILE F H      1 
ATOM   1325 H  HA     . ILE C 3 25 ? 18.29064  8.15425   5.42211   1.000 18.47042 ? 189 ILE F HA     1 
ATOM   1326 H  HB     . ILE C 3 25 ? 16.35889  8.61988   4.07578   1.000 12.08002 ? 189 ILE F HB     1 
ATOM   1327 H  HG12   . ILE C 3 25 ? 18.17250  6.82779   2.86297   1.000 14.06266 ? 189 ILE F HG12   1 
ATOM   1328 H  HG13   . ILE C 3 25 ? 17.23179  6.45046   4.08694   1.000 14.06266 ? 189 ILE F HG13   1 
ATOM   1329 H  HG21   . ILE C 3 25 ? 16.52321  9.30979   1.94500   1.000 15.58242 ? 189 ILE F HG21   1 
ATOM   1330 H  HG22   . ILE C 3 25 ? 17.51730  10.26466  2.73463   1.000 15.58242 ? 189 ILE F HG22   1 
ATOM   1331 H  HG23   . ILE C 3 25 ? 18.08759  9.03686   1.90349   1.000 15.58242 ? 189 ILE F HG23   1 
ATOM   1332 H  HD11   . ILE C 3 25 ? 16.26016  5.60236   2.20561   1.000 17.03874 ? 189 ILE F HD11   1 
ATOM   1333 H  HD12   . ILE C 3 25 ? 15.36267  6.82535   2.67712   1.000 17.03874 ? 189 ILE F HD12   1 
ATOM   1334 H  HD13   . ILE C 3 25 ? 16.37238  7.00248   1.46360   1.000 17.03874 ? 189 ILE F HD13   1 
ATOM   1335 N  N      . TRP C 3 26 ? 20.37867  7.73549   4.16765   1.000 11.96435 ? 190 TRP F N      1 
ATOM   1336 C  CA     . TRP C 3 26 ? 21.71972  7.67525   3.59395   1.000 14.31149 ? 190 TRP F CA     1 
ATOM   1337 C  C      . TRP C 3 26 ? 22.10058  6.24228   3.24824   1.000 13.06910 ? 190 TRP F C      1 
ATOM   1338 O  O      . TRP C 3 26 ? 21.59381  5.27890   3.82169   1.000 13.27010 ? 190 TRP F O      1 
ATOM   1339 C  CB     . TRP C 3 26 ? 22.76629  8.25698   4.56397   1.000 14.70578 ? 190 TRP F CB     1 
ATOM   1340 C  CG     . TRP C 3 26 ? 22.61762  7.75803   5.96146   1.000 11.93273 ? 190 TRP F CG     1 
ATOM   1341 C  CD1    . TRP C 3 26 ? 23.07178  6.56402   6.48701   1.000 12.37417 ? 190 TRP F CD1    1 
ATOM   1342 C  CD2    . TRP C 3 26 ? 21.99144  8.44858   7.04099   1.000 14.83847 ? 190 TRP F CD2    1 
ATOM   1343 N  NE1    . TRP C 3 26 ? 22.73624  6.47303   7.80228   1.000 15.48509 ? 190 TRP F NE1    1 
ATOM   1344 C  CE2    . TRP C 3 26 ? 22.06896  7.61755   8.17069   1.000 14.05019 ? 190 TRP F CE2    1 
ATOM   1345 C  CE3    . TRP C 3 26 ? 21.34463  9.69100   7.15531   1.000 15.97901 ? 190 TRP F CE3    1 
ATOM   1346 C  CZ2    . TRP C 3 26 ? 21.53668  7.98123   9.39251   1.000 16.61993 ? 190 TRP F CZ2    1 
ATOM   1347 C  CZ3    . TRP C 3 26 ? 20.81642  10.04848  8.38989   1.000 16.38581 ? 190 TRP F CZ3    1 
ATOM   1348 C  CH2    . TRP C 3 26 ? 20.92858  9.20430   9.48137   1.000 14.72512 ? 190 TRP F CH2    1 
ATOM   1349 H  H      . TRP C 3 26 ? 20.10341  7.00266   4.52372   1.000 14.35722 ? 190 TRP F H      1 
ATOM   1350 H  HA     . TRP C 3 26 ? 21.70745  8.18358   2.76791   1.000 17.17379 ? 190 TRP F HA     1 
ATOM   1351 H  HB2    . TRP C 3 26 ? 23.65204  8.01261   4.25311   1.000 17.64693 ? 190 TRP F HB2    1 
ATOM   1352 H  HB3    . TRP C 3 26 ? 22.67542  9.22256   4.58120   1.000 17.64693 ? 190 TRP F HB3    1 
ATOM   1353 H  HD1    . TRP C 3 26 ? 23.53918  5.91624   6.01075   1.000 14.84901 ? 190 TRP F HD1    1 
ATOM   1354 H  HE1    . TRP C 3 26 ? 22.91259  5.80844   8.31882   1.000 18.58211 ? 190 TRP F HE1    1 
ATOM   1355 H  HE3    . TRP C 3 26 ? 21.27194  10.25969  6.42304   1.000 19.17482 ? 190 TRP F HE3    1 
ATOM   1356 H  HZ2    . TRP C 3 26 ? 21.58962  7.41519   10.12851  1.000 19.94392 ? 190 TRP F HZ2    1 
ATOM   1357 H  HZ3    . TRP C 3 26 ? 20.38196  10.86534  8.48413   1.000 19.66297 ? 190 TRP F HZ3    1 
ATOM   1358 H  HH2    . TRP C 3 26 ? 20.58028  9.47640   10.29963  1.000 17.67014 ? 190 TRP F HH2    1 
ATOM   1359 N  N      . TRP C 3 27 ? 23.05599  6.11309   2.33130   1.000 13.00406 ? 191 TRP F N      1 
ATOM   1360 C  CA     . TRP C 3 27 ? 23.63714  4.80972   2.07692   1.000 11.15361 ? 191 TRP F CA     1 
ATOM   1361 C  C      . TRP C 3 27 ? 24.47438  4.36239   3.26621   1.000 12.73707 ? 191 TRP F C      1 
ATOM   1362 O  O      . TRP C 3 27 ? 25.16676  5.16602   3.90809   1.000 13.31997 ? 191 TRP F O      1 
ATOM   1363 C  CB     . TRP C 3 27 ? 24.53409  4.83310   0.84228   1.000 15.18277 ? 191 TRP F CB     1 
ATOM   1364 C  CG     . TRP C 3 27 ? 23.85725  5.09859   -0.46331  1.000 14.67084 ? 191 TRP F CG     1 
ATOM   1365 C  CD1    . TRP C 3 27 ? 24.02396  6.18311   -1.26248  1.000 16.42856 ? 191 TRP F CD1    1 
ATOM   1366 C  CD2    . TRP C 3 27 ? 22.94200  4.23581   -1.14068  1.000 13.51684 ? 191 TRP F CD2    1 
ATOM   1367 N  NE1    . TRP C 3 27 ? 23.28025  6.04811   -2.40041  1.000 14.66933 ? 191 TRP F NE1    1 
ATOM   1368 C  CE2    . TRP C 3 27 ? 22.59387  4.86362   -2.34651  1.000 12.56569 ? 191 TRP F CE2    1 
ATOM   1369 C  CE3    . TRP C 3 27 ? 22.39210  2.98254   -0.84546  1.000 12.50251 ? 191 TRP F CE3    1 
ATOM   1370 C  CZ2    . TRP C 3 27 ? 21.69855  4.28892   -3.25577  1.000 12.33783 ? 191 TRP F CZ2    1 
ATOM   1371 C  CZ3    . TRP C 3 27 ? 21.51120  2.41745   -1.73664  1.000 13.76881 ? 191 TRP F CZ3    1 
ATOM   1372 C  CH2    . TRP C 3 27 ? 21.16465  3.07412   -2.92821  1.000 16.80108 ? 191 TRP F CH2    1 
ATOM   1373 H  H      . TRP C 3 27 ? 23.37547  6.75408   1.85521   1.000 15.60487 ? 191 TRP F H      1 
ATOM   1374 H  HA     . TRP C 3 27 ? 22.91482  4.18055   1.92423   1.000 13.38433 ? 191 TRP F HA     1 
ATOM   1375 H  HB2    . TRP C 3 27 ? 25.19900  5.52858   0.96520   1.000 18.21933 ? 191 TRP F HB2    1 
ATOM   1376 H  HB3    . TRP C 3 27 ? 24.96796  3.96875   0.76780   1.000 18.21933 ? 191 TRP F HB3    1 
ATOM   1377 H  HD1    . TRP C 3 27 ? 24.56594  6.91235   -1.06408  1.000 19.71428 ? 191 TRP F HD1    1 
ATOM   1378 H  HE1    . TRP C 3 27 ? 23.24811  6.61506   -3.04627  1.000 17.60319 ? 191 TRP F HE1    1 
ATOM   1379 H  HE3    . TRP C 3 27 ? 22.61899  2.53984   -0.05969  1.000 15.00302 ? 191 TRP F HE3    1 
ATOM   1380 H  HZ2    . TRP C 3 27 ? 21.47579  4.71649   -4.05104  1.000 14.80540 ? 191 TRP F HZ2    1 
ATOM   1381 H  HZ3    . TRP C 3 27 ? 21.13871  1.58663   -1.54720  1.000 16.52257 ? 191 TRP F HZ3    1 
ATOM   1382 H  HH2    . TRP C 3 27 ? 20.55787  2.67332   -3.50793  1.000 20.16130 ? 191 TRP F HH2    1 
ATOM   1383 N  N      . VAL C 3 28 ? 24.43847  3.05644   3.52329   1.000 12.01460 ? 192 VAL F N      1 
ATOM   1384 C  CA     . VAL C 3 28 ? 25.36120  2.41673   4.45768   1.000 11.71506 ? 192 VAL F CA     1 
ATOM   1385 C  C      . VAL C 3 28 ? 26.49558  1.81013   3.64544   1.000 14.74259 ? 192 VAL F C      1 
ATOM   1386 O  O      . VAL C 3 28 ? 27.66678  2.16290   3.83609   1.000 17.84062 ? 192 VAL F O      1 
ATOM   1387 C  CB     . VAL C 3 28 ? 24.65602  1.36282   5.32616   1.000 16.49627 ? 192 VAL F CB     1 
ATOM   1388 C  CG1    . VAL C 3 28 ? 25.66187  0.68660   6.25534   1.000 22.39119 ? 192 VAL F CG1    1 
ATOM   1389 C  CG2    . VAL C 3 28 ? 23.58525  2.03623   6.14912   1.000 14.39226 ? 192 VAL F CG2    1 
ATOM   1390 H  H      . VAL C 3 28 ? 23.87975  2.51073   3.16325   1.000 14.41752 ? 192 VAL F H      1 
ATOM   1391 H  HA     . VAL C 3 28 ? 25.72603  3.07960   5.06464   1.000 14.05808 ? 192 VAL F HA     1 
ATOM   1392 H  HB     . VAL C 3 28 ? 24.25582  0.68721   4.75669   1.000 19.79552 ? 192 VAL F HB     1 
ATOM   1393 H  HG11   . VAL C 3 28 ? 25.18108  0.14550   6.90106   1.000 26.86942 ? 192 VAL F HG11   1 
ATOM   1394 H  HG12   . VAL C 3 28 ? 26.25176  0.12577   5.72770   1.000 26.86942 ? 192 VAL F HG12   1 
ATOM   1395 H  HG13   . VAL C 3 28 ? 26.17675  1.36904   6.71369   1.000 26.86942 ? 192 VAL F HG13   1 
ATOM   1396 H  HG21   . VAL C 3 28 ? 23.21402  1.39215   6.77223   1.000 17.27072 ? 192 VAL F HG21   1 
ATOM   1397 H  HG22   . VAL C 3 28 ? 23.97974  2.77722   6.63514   1.000 17.27072 ? 192 VAL F HG22   1 
ATOM   1398 H  HG23   . VAL C 3 28 ? 22.88976  2.36208   5.55666   1.000 17.27072 ? 192 VAL F HG23   1 
ATOM   1399 N  N      . ASP C 3 29 ? 26.15316  0.90313   2.73496   1.000 14.76705 ? 193 ASP F N      1 
ATOM   1400 C  CA     . ASP C 3 29 ? 27.08235  0.37747   1.73714   1.000 12.94304 ? 193 ASP F CA     1 
ATOM   1401 C  C      . ASP C 3 29 ? 26.37280  0.45348   0.38833   1.000 15.10797 ? 193 ASP F C      1 
ATOM   1402 O  O      . ASP C 3 29 ? 25.55335  -0.40434  0.05229   1.000 15.82489 ? 193 ASP F O      1 
ATOM   1403 C  CB     . ASP C 3 29 ? 27.51701  -1.04673  2.06932   1.000 12.90153 ? 193 ASP F CB     1 
ATOM   1404 C  CG     . ASP C 3 29 ? 28.56756  -1.57446  1.09576   1.000 18.73745 ? 193 ASP F CG     1 
ATOM   1405 O  OD1    . ASP C 3 29 ? 28.57749  -1.10919  -0.05025  1.000 16.78087 ? 193 ASP F OD1    1 
ATOM   1406 O  OD2    . ASP C 3 29 ? 29.38444  -2.43829  1.49407   1.000 20.05024 ? 193 ASP F OD2    1 
ATOM   1407 H  H      . ASP C 3 29 ? 25.36422  0.56649   2.67299   1.000 17.72046 ? 193 ASP F H      1 
ATOM   1408 H  HA     . ASP C 3 29 ? 27.88129  0.92671   1.70674   1.000 15.53165 ? 193 ASP F HA     1 
ATOM   1409 H  HB2    . ASP C 3 29 ? 27.89726  -1.06295  2.96153   1.000 15.48183 ? 193 ASP F HB2    1 
ATOM   1410 H  HB3    . ASP C 3 29 ? 26.74506  -1.63257  2.02698   1.000 15.48183 ? 193 ASP F HB3    1 
ATOM   1411 N  N      . LYS C 3 30 ? 26.67472  1.48578   -0.39706  1.000 15.85516 ? 194 LYS F N      1 
ATOM   1412 C  CA     . LYS C 3 30 ? 25.90080  1.67697   -1.61589  1.000 21.08089 ? 194 LYS F CA     1 
ATOM   1413 C  C      . LYS C 3 30 ? 26.14113  0.55623   -2.60213  1.000 18.27163 ? 194 LYS F C      1 
ATOM   1414 O  O      . LYS C 3 30 ? 25.22266  0.17538   -3.32486  1.000 15.45601 ? 194 LYS F O      1 
ATOM   1415 C  CB     . LYS C 3 30 ? 26.20654  3.02555   -2.24011  1.000 26.37547 ? 194 LYS F CB     1 
ATOM   1416 C  CG     . LYS C 3 30 ? 27.65160  3.25076   -2.50767  1.000 24.71482 ? 194 LYS F CG     1 
ATOM   1417 C  CD     . LYS C 3 30 ? 27.91446  4.73463   -2.75769  1.000 28.75681 ? 194 LYS F CD     1 
ATOM   1418 C  CE     . LYS C 3 30 ? 29.41091  5.00642   -2.66439  1.000 25.16619 ? 194 LYS F CE     1 
ATOM   1419 N  NZ     . LYS C 3 30 ? 29.75378  6.42405   -2.97756  1.000 35.54728 ? 194 LYS F NZ     1 
ATOM   1420 H  H      . LYS C 3 30 ? 27.29532  2.06322   -0.25211  1.000 19.02619 ? 194 LYS F H      1 
ATOM   1421 H  HA     . LYS C 3 30 ? 24.95768  1.67793   -1.38909  1.000 25.29707 ? 194 LYS F HA     1 
ATOM   1422 H  HB2    . LYS C 3 30 ? 25.73553  3.09132   -3.08552  1.000 31.65056 ? 194 LYS F HB2    1 
ATOM   1423 H  HB3    . LYS C 3 30 ? 25.90520  3.72320   -1.63730  1.000 31.65056 ? 194 LYS F HB3    1 
ATOM   1424 H  HG2    . LYS C 3 30 ? 28.17373  2.96766   -1.74076  1.000 29.65779 ? 194 LYS F HG2    1 
ATOM   1425 H  HG3    . LYS C 3 30 ? 27.91984  2.75085   -3.29445  1.000 29.65779 ? 194 LYS F HG3    1 
ATOM   1426 H  HD2    . LYS C 3 30 ? 27.60603  4.97882   -3.64434  1.000 34.50817 ? 194 LYS F HD2    1 
ATOM   1427 H  HD3    . LYS C 3 30 ? 27.45663  5.26739   -2.08877  1.000 34.50817 ? 194 LYS F HD3    1 
ATOM   1428 H  HE2    . LYS C 3 30 ? 29.71239  4.81617   -1.76228  1.000 30.19942 ? 194 LYS F HE2    1 
ATOM   1429 H  HE3    . LYS C 3 30 ? 29.87686  4.43738   -3.29684  1.000 30.19942 ? 194 LYS F HE3    1 
ATOM   1430 H  HZ1    . LYS C 3 30 ? 30.62694  6.55731   -2.86837  1.000 42.65674 ? 194 LYS F HZ1    1 
ATOM   1431 H  HZ2    . LYS C 3 30 ? 29.53623  6.61085   -3.82011  1.000 42.65674 ? 194 LYS F HZ2    1 
ATOM   1432 H  HZ3    . LYS C 3 30 ? 29.30805  6.97183   -2.43593  1.000 42.65674 ? 194 LYS F HZ3    1 
ATOM   1433 N  N      . ASP C 3 31 ? 27.34167  -0.02320  -2.61460  1.000 17.00620 ? 195 ASP F N      1 
ATOM   1434 C  CA     . ASP C 3 31 ? 27.58674  -1.13577  -3.52745  1.000 20.48846 ? 195 ASP F CA     1 
ATOM   1435 C  C      . ASP C 3 31 ? 26.63689  -2.29733  -3.26264  1.000 19.87044 ? 195 ASP F C      1 
ATOM   1436 O  O      . ASP C 3 31 ? 26.19095  -2.97441  -4.19828  1.000 20.60520 ? 195 ASP F O      1 
ATOM   1437 C  CB     . ASP C 3 31 ? 29.02839  -1.60461  -3.38838  1.000 23.22397 ? 195 ASP F CB     1 
ATOM   1438 C  CG     . ASP C 3 31 ? 30.01331  -0.66120  -4.04600  1.000 20.12213 ? 195 ASP F CG     1 
ATOM   1439 O  OD1    . ASP C 3 31 ? 29.81575  0.57152   -3.99942  1.000 18.89726 ? 195 ASP F OD1    1 
ATOM   1440 O  OD2    . ASP C 3 31 ? 30.98769  -1.17816  -4.61837  1.000 20.73542 ? 195 ASP F OD2    1 
ATOM   1441 H  H      . ASP C 3 31 ? 28.00891  0.20166   -2.12082  1.000 20.40744 ? 195 ASP F H      1 
ATOM   1442 H  HA     . ASP C 3 31 ? 27.44194  -0.82797  -4.43585  1.000 24.58615 ? 195 ASP F HA     1 
ATOM   1443 H  HB2    . ASP C 3 31 ? 29.25248  -1.66440  -2.44651  1.000 27.86877 ? 195 ASP F HB2    1 
ATOM   1444 H  HB3    . ASP C 3 31 ? 29.12021  -2.47474  -3.80713  1.000 27.86877 ? 195 ASP F HB3    1 
ATOM   1445 N  N      . LYS C 3 32 ? 26.34445  -2.56223  -1.99006  1.000 14.40587 ? 196 LYS F N      1 
ATOM   1446 C  CA     . LYS C 3 32 ? 25.39815  -3.59175  -1.57794  1.000 17.80546 ? 196 LYS F CA     1 
ATOM   1447 C  C      . LYS C 3 32 ? 23.95096  -3.11568  -1.58404  1.000 13.65166 ? 196 LYS F C      1 
ATOM   1448 O  O      . LYS C 3 32 ? 23.05439  -3.94176  -1.40201  1.000 17.97832 ? 196 LYS F O      1 
ATOM   1449 C  CB     . LYS C 3 32 ? 25.73680  -4.08207  -0.16742  1.000 17.89717 ? 196 LYS F CB     1 
ATOM   1450 C  CG     . LYS C 3 32 ? 27.11476  -4.75724  -0.01706  1.000 20.80355 ? 196 LYS F CG     1 
ATOM   1451 C  CD     . LYS C 3 32 ? 27.25858  -5.29180  1.39558   1.000 28.94078 ? 196 LYS F CD     1 
ATOM   1452 C  CE     . LYS C 3 32 ? 28.63098  -5.91113  1.62835   1.000 37.10951 ? 196 LYS F CE     1 
ATOM   1453 N  NZ     . LYS C 3 32 ? 28.94535  -5.99425  3.08330   1.000 32.13836 ? 196 LYS F NZ     1 
ATOM   1454 H  H      . LYS C 3 32 ? 26.69383  -2.14410  -1.32471  1.000 17.28704 ? 196 LYS F H      1 
ATOM   1455 H  HA     . LYS C 3 32 ? 25.47803  -4.33493  -2.19617  1.000 21.36656 ? 196 LYS F HA     1 
ATOM   1456 H  HB2    . LYS C 3 32 ? 25.72058  -3.32048  0.43309   1.000 21.47660 ? 196 LYS F HB2    1 
ATOM   1457 H  HB3    . LYS C 3 32 ? 25.06631  -4.72993  0.10022   1.000 21.47660 ? 196 LYS F HB3    1 
ATOM   1458 H  HG2    . LYS C 3 32 ? 27.19018  -5.49556  -0.64163  1.000 24.96426 ? 196 LYS F HG2    1 
ATOM   1459 H  HG3    . LYS C 3 32 ? 27.81866  -4.11040  -0.18146  1.000 24.96426 ? 196 LYS F HG3    1 
ATOM   1460 H  HD2    . LYS C 3 32 ? 27.14266  -4.56433  2.02666   1.000 34.72894 ? 196 LYS F HD2    1 
ATOM   1461 H  HD3    . LYS C 3 32 ? 26.58713  -5.97470  1.54952   1.000 34.72894 ? 196 LYS F HD3    1 
ATOM   1462 H  HE2    . LYS C 3 32 ? 28.64632  -6.80831  1.25995   1.000 44.53141 ? 196 LYS F HE2    1 
ATOM   1463 H  HE3    . LYS C 3 32 ? 29.30803  -5.36474  1.19944   1.000 44.53141 ? 196 LYS F HE3    1 
ATOM   1464 H  HZ1    . LYS C 3 32 ? 28.32542  -6.47676  3.50159   1.000 38.56603 ? 196 LYS F HZ1    1 
ATOM   1465 H  HZ2    . LYS C 3 32 ? 29.73921  -6.37879  3.20171   1.000 38.56603 ? 196 LYS F HZ2    1 
ATOM   1466 H  HZ3    . LYS C 3 32 ? 28.96399  -5.17811  3.43780   1.000 38.56603 ? 196 LYS F HZ3    1 
ATOM   1467 N  N      . GLY C 3 33 ? 23.71214  -1.82479  -1.77452  1.000 15.08982 ? 197 GLY F N      1 
ATOM   1468 C  CA     . GLY C 3 33 ? 22.36988  -1.28323  -1.73675  1.000 15.20098 ? 197 GLY F CA     1 
ATOM   1469 C  C      . GLY C 3 33 ? 21.76117  -1.15358  -0.36641  1.000 13.54744 ? 197 GLY F C      1 
ATOM   1470 O  O      . GLY C 3 33 ? 20.53125  -1.08134  -0.25008  1.000 14.49985 ? 197 GLY F O      1 
ATOM   1471 H  H      . GLY C 3 33 ? 24.32006  -1.23649  -1.92923  1.000 18.10778 ? 197 GLY F H      1 
ATOM   1472 H  HA2    . GLY C 3 33 ? 22.38299  -0.39939  -2.13618  1.000 18.24118 ? 197 GLY F HA2    1 
ATOM   1473 H  HA3    . GLY C 3 33 ? 21.79087  -1.85823  -2.26118  1.000 18.24118 ? 197 GLY F HA3    1 
ATOM   1474 N  N      . THR C 3 34 ? 22.57418  -1.12628  0.69318   1.000 13.37970 ? 198 THR F N      1 
ATOM   1475 C  CA     . THR C 3 34 ? 22.05279  -0.98003  2.04465   1.000 13.31465 ? 198 THR F CA     1 
ATOM   1476 C  C      . THR C 3 34 ? 21.96399  0.50305   2.38592   1.000 13.24124 ? 198 THR F C      1 
ATOM   1477 O  O      . THR C 3 34 ? 22.84306  1.29841   2.04082   1.000 14.44024 ? 198 THR F O      1 
ATOM   1478 C  CB     . THR C 3 34 ? 22.92477  -1.70623  3.06932   1.000 14.30221 ? 198 THR F CB     1 
ATOM   1479 O  OG1    . THR C 3 34 ? 24.25554  -1.20000  2.97255   1.000 13.78932 ? 198 THR F OG1    1 
ATOM   1480 C  CG2    . THR C 3 34 ? 22.90554  -3.21014  2.82870   1.000 15.68875 ? 198 THR F CG2    1 
ATOM   1481 H  H      . THR C 3 34 ? 23.43067  -1.19100  0.65014   1.000 16.05565 ? 198 THR F H      1 
ATOM   1482 H  HA     . THR C 3 34 ? 21.16872  -1.37588  2.09590   1.000 15.97758 ? 198 THR F HA     1 
ATOM   1483 H  HB     . THR C 3 34 ? 22.58681  -1.55828  3.96642   1.000 17.16265 ? 198 THR F HB     1 
ATOM   1484 H  HG1    . THR C 3 34 ? 24.73212  -1.52633  3.58245   1.000 16.54718 ? 198 THR F HG1    1 
ATOM   1485 H  HG21   . THR C 3 34 ? 23.43103  -3.66151  3.50769   1.000 18.82650 ? 198 THR F HG21   1 
ATOM   1486 H  HG22   . THR C 3 34 ? 21.99417  -3.54028  2.86485   1.000 18.82650 ? 198 THR F HG22   1 
ATOM   1487 H  HG23   . THR C 3 34 ? 23.27887  -3.41135  1.95632   1.000 18.82650 ? 198 THR F HG23   1 
ATOM   1488 N  N      . PHE C 3 35 ? 20.87379  0.87557   3.03953   1.000 12.08566 ? 199 PHE F N      1 
ATOM   1489 C  CA     . PHE C 3 35 ? 20.61688  2.27054   3.35607   1.000 12.31082 ? 199 PHE F CA     1 
ATOM   1490 C  C      . PHE C 3 35 ? 19.89793  2.32540   4.69160   1.000 12.88063 ? 199 PHE F C      1 
ATOM   1491 O  O      . PHE C 3 35 ? 19.32963  1.33688   5.15139   1.000 12.16504 ? 199 PHE F O      1 
ATOM   1492 C  CB     . PHE C 3 35 ? 19.79334  2.95853   2.27781   1.000 13.67774 ? 199 PHE F CB     1 
ATOM   1493 C  CG     . PHE C 3 35 ? 18.40949  2.36175   2.06673   1.000 11.33873 ? 199 PHE F CG     1 
ATOM   1494 C  CD1    . PHE C 3 35 ? 18.21942  1.30379   1.20371   1.000 11.12566 ? 199 PHE F CD1    1 
ATOM   1495 C  CD2    . PHE C 3 35 ? 17.31375  2.89502   2.71301   1.000 12.53469 ? 199 PHE F CD2    1 
ATOM   1496 C  CE1    . PHE C 3 35 ? 16.96221  0.77492   0.99269   1.000 12.49405 ? 199 PHE F CE1    1 
ATOM   1497 C  CE2    . PHE C 3 35 ? 16.03333  2.37500   2.50680   1.000 12.32142 ? 199 PHE F CE2    1 
ATOM   1498 C  CZ     . PHE C 3 35 ? 15.85413  1.32276   1.64424   1.000 11.47947 ? 199 PHE F CZ     1 
ATOM   1499 H  H      . PHE C 3 35 ? 20.26305  0.33515   3.31256   1.000 14.50279 ? 199 PHE F H      1 
ATOM   1500 H  HA     . PHE C 3 35 ? 21.45811  2.74770   3.43058   1.000 14.77298 ? 199 PHE F HA     1 
ATOM   1501 H  HB2    . PHE C 3 35 ? 19.67679  3.88941   2.52434   1.000 16.41329 ? 199 PHE F HB2    1 
ATOM   1502 H  HB3    . PHE C 3 35 ? 20.27135  2.89559   1.43612   1.000 16.41329 ? 199 PHE F HB3    1 
ATOM   1503 H  HD1    . PHE C 3 35 ? 18.94970  0.94077   0.75671   1.000 13.35079 ? 199 PHE F HD1    1 
ATOM   1504 H  HD2    . PHE C 3 35 ? 17.42894  3.61143   3.29472   1.000 15.04162 ? 199 PHE F HD2    1 
ATOM   1505 H  HE1    . PHE C 3 35 ? 16.85245  0.05332   0.41636   1.000 14.99286 ? 199 PHE F HE1    1 
ATOM   1506 H  HE2    . PHE C 3 35 ? 15.30418  2.74116   2.95309   1.000 14.78571 ? 199 PHE F HE2    1 
ATOM   1507 H  HZ     . PHE C 3 35 ? 15.00354  0.97769   1.49483   1.000 13.77536 ? 199 PHE F HZ     1 
ATOM   1508 N  N      . GLN C 3 36 ? 19.95811  3.48376   5.32532   1.000 11.14341 ? 200 GLN F N      1 
ATOM   1509 C  CA     . GLN C 3 36 ? 19.46513  3.61865   6.68192   1.000 9.17922  ? 200 GLN F CA     1 
ATOM   1510 C  C      . GLN C 3 36 ? 18.73256  4.94309   6.81383   1.000 12.65891 ? 200 GLN F C      1 
ATOM   1511 O  O      . GLN C 3 36 ? 19.14463  5.95231   6.22851   1.000 11.68010 ? 200 GLN F O      1 
ATOM   1512 C  CB     . GLN C 3 36 ? 20.62320  3.53394   7.69493   1.000 14.06918 ? 200 GLN F CB     1 
ATOM   1513 C  CG     . GLN C 3 36 ? 20.27084  3.81814   9.13308   1.000 14.56417 ? 200 GLN F CG     1 
ATOM   1514 C  CD     . GLN C 3 36 ? 21.48313  3.68647   10.04008  1.000 18.39059 ? 200 GLN F CD     1 
ATOM   1515 O  OE1    . GLN C 3 36 ? 22.51894  4.32471   9.80821   1.000 17.95999 ? 200 GLN F OE1    1 
ATOM   1516 N  NE2    . GLN C 3 36 ? 21.37289  2.85460   11.06261  1.000 22.06322 ? 200 GLN F NE2    1 
ATOM   1517 H  H      . GLN C 3 36 ? 20.28073  4.20677   4.98950   1.000 13.37210 ? 200 GLN F H      1 
ATOM   1518 H  HA     . GLN C 3 36 ? 18.83405  2.91062   6.88520   1.000 11.01506 ? 200 GLN F HA     1 
ATOM   1519 H  HB2    . GLN C 3 36 ? 20.98842  2.63592   7.66229   1.000 16.88302 ? 200 GLN F HB2    1 
ATOM   1520 H  HB3    . GLN C 3 36 ? 21.30069  4.17730   7.43420   1.000 16.88302 ? 200 GLN F HB3    1 
ATOM   1521 H  HG2    . GLN C 3 36 ? 19.93100  4.72362   9.20731   1.000 17.47700 ? 200 GLN F HG2    1 
ATOM   1522 H  HG3    . GLN C 3 36 ? 19.59769  3.18579   9.42955   1.000 17.47700 ? 200 GLN F HG3    1 
ATOM   1523 H  HE21   . GLN C 3 36 ? 20.64080  2.42081   11.18704  1.000 26.47586 ? 200 GLN F HE21   1 
ATOM   1524 H  HE22   . GLN C 3 36 ? 22.03330  2.74754   11.60297  1.000 26.47586 ? 200 GLN F HE22   1 
ATOM   1525 N  N      . PHE C 3 37 ? 17.62475  4.92035   7.55877   1.000 13.25784 ? 201 PHE F N      1 
ATOM   1526 C  CA     . PHE C 3 37 ? 16.89496  6.12462   7.91297   1.000 11.80663 ? 201 PHE F CA     1 
ATOM   1527 C  C      . PHE C 3 37 ? 17.41231  6.73783   9.21085   1.000 10.25373 ? 201 PHE F C      1 
ATOM   1528 O  O      . PHE C 3 37 ? 17.86817  6.04504   10.12982  1.000 13.54134 ? 201 PHE F O      1 
ATOM   1529 C  CB     . PHE C 3 37 ? 15.40200  5.84710   8.09486   1.000 10.33979 ? 201 PHE F CB     1 
ATOM   1530 C  CG     . PHE C 3 37 ? 14.70393  5.37705   6.85070   1.000 9.63274  ? 201 PHE F CG     1 
ATOM   1531 C  CD1    . PHE C 3 37 ? 14.23230  6.29547   5.93696   1.000 13.45682 ? 201 PHE F CD1    1 
ATOM   1532 C  CD2    . PHE C 3 37 ? 14.51025  4.03144   6.61227   1.000 10.79808 ? 201 PHE F CD2    1 
ATOM   1533 C  CE1    . PHE C 3 37 ? 13.59261  5.88140   4.80834   1.000 13.33562 ? 201 PHE F CE1    1 
ATOM   1534 C  CE2    . PHE C 3 37 ? 13.87659  3.61018   5.48302   1.000 11.42007 ? 201 PHE F CE2    1 
ATOM   1535 C  CZ     . PHE C 3 37 ? 13.40952  4.52553   4.58272   1.000 10.99754 ? 201 PHE F CZ     1 
ATOM   1536 H  H      . PHE C 3 37 ? 17.27371  4.20155   7.87452   1.000 15.90941 ? 201 PHE F H      1 
ATOM   1537 H  HA     . PHE C 3 37 ? 17.02003  6.75675   7.18794   1.000 14.16795 ? 201 PHE F HA     1 
ATOM   1538 H  HB2    . PHE C 3 37 ? 15.29499  5.15845   8.76955   1.000 12.40775 ? 201 PHE F HB2    1 
ATOM   1539 H  HB3    . PHE C 3 37 ? 14.96795  6.66501   8.38386   1.000 12.40775 ? 201 PHE F HB3    1 
ATOM   1540 H  HD1    . PHE C 3 37 ? 14.35192  7.20453   6.09253   1.000 16.14819 ? 201 PHE F HD1    1 
ATOM   1541 H  HD2    . PHE C 3 37 ? 14.81565  3.40608   7.22917   1.000 12.95770 ? 201 PHE F HD2    1 
ATOM   1542 H  HE1    . PHE C 3 37 ? 13.28036  6.50436   4.19246   1.000 16.00274 ? 201 PHE F HE1    1 
ATOM   1543 H  HE2    . PHE C 3 37 ? 13.76195  2.70093   5.32488   1.000 13.70409 ? 201 PHE F HE2    1 
ATOM   1544 H  HZ     . PHE C 3 37 ? 12.96756  4.23847   3.81644   1.000 13.19704 ? 201 PHE F HZ     1 
ATOM   1545 N  N      . SER C 3 38 ? 17.31136  8.06094   9.27695   1.000 13.44792 ? 202 SER F N      1 
ATOM   1546 C  CA     . SER C 3 38 ? 17.57888  8.79051   10.50423  1.000 15.77059 ? 202 SER F CA     1 
ATOM   1547 C  C      . SER C 3 38 ? 16.50792  8.52315   11.55228  1.000 16.68244 ? 202 SER F C      1 
ATOM   1548 O  O      . SER C 3 38 ? 15.31415  8.65122   11.28026  1.000 14.69000 ? 202 SER F O      1 
ATOM   1549 C  CB     . SER C 3 38 ? 17.61271  10.28667  10.21867  1.000 14.84000 ? 202 SER F CB     1 
ATOM   1550 O  OG     . SER C 3 38 ? 17.62276  10.99419  11.44929  1.000 15.08547 ? 202 SER F OG     1 
ATOM   1551 H  H      . SER C 3 38 ? 17.08688  8.56355   8.61619   1.000 16.13750 ? 202 SER F H      1 
ATOM   1552 H  HA     . SER C 3 38 ? 18.43529  8.49729   10.85277  1.000 18.92471 ? 202 SER F HA     1 
ATOM   1553 H  HB2    . SER C 3 38 ? 18.41435  10.50131  9.71647   1.000 17.80800 ? 202 SER F HB2    1 
ATOM   1554 H  HB3    . SER C 3 38 ? 16.82559  10.53591  9.70954   1.000 17.80800 ? 202 SER F HB3    1 
ATOM   1555 H  HG     . SER C 3 38 ? 17.55970  11.81959  11.30666  1.000 18.10256 ? 202 SER F HG     1 
ATOM   1556 N  N      . SER C 3 39 ? 16.92556  8.21827   12.77630  1.000 14.02970 ? 203 SER F N      1 
ATOM   1557 C  CA     . SER C 3 39 ? 15.94909  8.05891   13.84917  1.000 16.80989 ? 203 SER F CA     1 
ATOM   1558 C  C      . SER C 3 39 ? 15.14189  9.33795   14.05357  1.000 15.11082 ? 203 SER F C      1 
ATOM   1559 O  O      . SER C 3 39 ? 13.90917  9.30990   14.15652  1.000 17.70841 ? 203 SER F O      1 
ATOM   1560 C  CB     . SER C 3 39 ? 16.67302  7.66487   15.14071  1.000 21.17662 ? 203 SER F CB     1 
ATOM   1561 O  OG     . SER C 3 39 ? 15.75462  7.49953   16.19524  1.000 30.28146 ? 203 SER F OG     1 
ATOM   1562 H  H      . SER C 3 39 ? 17.74573  8.10124   13.00700  1.000 16.83564 ? 203 SER F H      1 
ATOM   1563 H  HA     . SER C 3 39 ? 15.32935  7.35086   13.61358  1.000 20.17186 ? 203 SER F HA     1 
ATOM   1564 H  HB2    . SER C 3 39 ? 17.14373  6.82898   14.99715  1.000 25.41194 ? 203 SER F HB2    1 
ATOM   1565 H  HB3    . SER C 3 39 ? 17.30276  8.36401   15.37633  1.000 25.41194 ? 203 SER F HB3    1 
ATOM   1566 H  HG     . SER C 3 39 ? 15.22413  6.87265   16.01858  1.000 36.33775 ? 203 SER F HG     1 
ATOM   1567 N  N      . LYS C 3 40 ? 15.82935  10.47936  14.10909  1.000 15.87342 ? 204 LYS F N      1 
ATOM   1568 C  CA     . LYS C 3 40 ? 15.20329  11.74699  14.43365  1.000 16.86291 ? 204 LYS F CA     1 
ATOM   1569 C  C      . LYS C 3 40 ? 14.55991  12.44539  13.24600  1.000 16.65014 ? 204 LYS F C      1 
ATOM   1570 O  O      . LYS C 3 40 ? 13.66947  13.28024  13.44837  1.000 18.87218 ? 204 LYS F O      1 
ATOM   1571 C  CB     . LYS C 3 40 ? 16.25391  12.68099  15.04438  0.989 29.82897 ? 204 LYS F CB     1 
ATOM   1572 C  CG     . LYS C 3 40 ? 16.48184  12.44934  16.53316  1.000 40.27641 ? 204 LYS F CG     1 
ATOM   1573 C  CD     . LYS C 3 40 ? 15.41354  13.11722  17.37899  0.955 42.20714 ? 204 LYS F CD     1 
ATOM   1574 C  CE     . LYS C 3 40 ? 15.44846  14.64305  17.23508  0.800 35.33882 ? 204 LYS F CE     1 
ATOM   1575 N  NZ     . LYS C 3 40 ? 14.46186  15.29492  18.10700  0.681 30.81361 ? 204 LYS F NZ     1 
ATOM   1576 H  H      . LYS C 3 40 ? 16.67394  10.54147  13.95939  1.000 19.04810 ? 204 LYS F H      1 
ATOM   1577 H  HA     . LYS C 3 40 ? 14.49874  11.57756  15.07848  1.000 20.23549 ? 204 LYS F HA     1 
ATOM   1578 H  HB2    . LYS C 3 40 ? 17.09896  12.54120  14.58914  1.000 35.79477 ? 204 LYS F HB2    1 
ATOM   1579 H  HB3    . LYS C 3 40 ? 15.96206  13.59866  14.92774  1.000 35.79477 ? 204 LYS F HB3    1 
ATOM   1580 H  HG2    . LYS C 3 40 ? 16.46160  11.49685  16.71551  1.000 48.33169 ? 204 LYS F HG2    1 
ATOM   1581 H  HG3    . LYS C 3 40 ? 17.34297  12.81731  16.78604  1.000 48.33169 ? 204 LYS F HG3    1 
ATOM   1582 H  HD2    . LYS C 3 40 ? 14.53958  12.80515  17.09667  1.000 50.64856 ? 204 LYS F HD2    1 
ATOM   1583 H  HD3    . LYS C 3 40 ? 15.55911  12.89646  18.31225  1.000 50.64856 ? 204 LYS F HD3    1 
ATOM   1584 H  HE2    . LYS C 3 40 ? 16.32984  14.96742  17.47768  1.000 42.40658 ? 204 LYS F HE2    1 
ATOM   1585 H  HE3    . LYS C 3 40 ? 15.24791  14.88269  16.31679  1.000 42.40658 ? 204 LYS F HE3    1 
ATOM   1586 H  HZ1    . LYS C 3 40 ? 14.50786  16.17856  18.01133  1.000 36.97633 ? 204 LYS F HZ1    1 
ATOM   1587 H  HZ2    . LYS C 3 40 ? 13.64133  15.02369  17.89424  0.953 36.97633 ? 204 LYS F HZ2    1 
ATOM   1588 H  HZ3    . LYS C 3 40 ? 14.62316  15.08767  18.95737  0.787 36.97633 ? 204 LYS F HZ3    1 
ATOM   1589 N  N      . HIS C 3 41 ? 14.98704  12.15445  12.01432  1.000 15.29927 ? 205 HIS F N      1 
ATOM   1590 C  CA     . HIS C 3 41 ? 14.52799  12.92249  10.86436  1.000 15.95626 ? 205 HIS F CA     1 
ATOM   1591 C  C      . HIS C 3 41 ? 13.81782  12.08656  9.80788   1.000 12.93800 ? 205 HIS F C      1 
ATOM   1592 O  O      . HIS C 3 41 ? 13.51352  12.60580  8.73304   1.000 12.32219 ? 205 HIS F O      1 
ATOM   1593 C  CB     . HIS C 3 41 ? 15.71087  13.68316  10.26054  1.000 17.16804 ? 205 HIS F CB     1 
ATOM   1594 C  CG     . HIS C 3 41 ? 16.35889  14.58577  11.25224  1.000 16.90034 ? 205 HIS F CG     1 
ATOM   1595 N  ND1    . HIS C 3 41 ? 15.67800  15.62685  11.85241  1.000 15.38379 ? 205 HIS F ND1    1 
ATOM   1596 C  CD2    . HIS C 3 41 ? 17.58630  14.55589  11.82087  1.000 22.72617 ? 205 HIS F CD2    1 
ATOM   1597 C  CE1    . HIS C 3 41 ? 16.47268  16.21562  12.72857  1.000 20.53188 ? 205 HIS F CE1    1 
ATOM   1598 N  NE2    . HIS C 3 41 ? 17.63634  15.59057  12.72355  1.000 20.40975 ? 205 HIS F NE2    1 
ATOM   1599 H  H      . HIS C 3 41 ? 15.53789  11.52160  11.82547  1.000 18.35912 ? 205 HIS F H      1 
ATOM   1600 H  HA     . HIS C 3 41 ? 13.87100  13.56914  11.16619  1.000 19.14751 ? 205 HIS F HA     1 
ATOM   1601 H  HB2    . HIS C 3 41 ? 16.37412  13.04681  9.95061   1.000 20.60165 ? 205 HIS F HB2    1 
ATOM   1602 H  HB3    . HIS C 3 41 ? 15.39700  14.22319  9.51841   1.000 20.60165 ? 205 HIS F HB3    1 
ATOM   1603 H  HD2    . HIS C 3 41 ? 18.26705  13.94989  11.63581  1.000 27.27141 ? 205 HIS F HD2    1 
ATOM   1604 H  HE1    . HIS C 3 41 ? 16.25036  16.94644  13.25902  1.000 24.63825 ? 205 HIS F HE1    1 
ATOM   1605 H  HE2    . HIS C 3 41 ? 18.31622  15.79796  13.20763  1.000 24.49170 ? 205 HIS F HE2    1 
ATOM   1606 N  N      . LYS C 3 42 ? 13.46285  10.84286  10.11876  1.000 13.82220 ? 206 LYS F N      1 
ATOM   1607 C  CA     . LYS C 3 42 ? 12.74044  10.02036  9.15499   1.000 14.37753 ? 206 LYS F CA     1 
ATOM   1608 C  C      . LYS C 3 42 ? 11.30507  10.51109  8.93275   1.000 10.69561 ? 206 LYS F C      1 
ATOM   1609 O  O      . LYS C 3 42 ? 10.75214  10.32782  7.84343   1.000 10.43576 ? 206 LYS F O      1 
ATOM   1610 C  CB     . LYS C 3 42 ? 12.76929  8.55868   9.61177   1.000 11.99484 ? 206 LYS F CB     1 
ATOM   1611 C  CG     . LYS C 3 42 ? 12.09947  8.26534   10.93468  1.000 14.40578 ? 206 LYS F CG     1 
ATOM   1612 C  CD     . LYS C 3 42 ? 12.45298  6.88258   11.43429  1.000 11.21040 ? 206 LYS F CD     1 
ATOM   1613 C  CE     . LYS C 3 42 ? 11.67923  6.47921   12.66002  1.000 15.19385 ? 206 LYS F CE     1 
ATOM   1614 N  NZ     . LYS C 3 42 ? 11.87696  7.41325   13.81159  1.000 20.71890 ? 206 LYS F NZ     1 
ATOM   1615 H  H      . LYS C 3 42 ? 13.62557  10.45674  10.86978  1.000 16.58664 ? 206 LYS F H      1 
ATOM   1616 H  HA     . LYS C 3 42 ? 13.18498  10.07253  8.29443   1.000 17.25303 ? 206 LYS F HA     1 
ATOM   1617 H  HB2    . LYS C 3 42 ? 12.32220  8.02186   8.93884   1.000 14.39381 ? 206 LYS F HB2    1 
ATOM   1618 H  HB3    . LYS C 3 42 ? 13.69623  8.28459   9.69279   1.000 14.39381 ? 206 LYS F HB3    1 
ATOM   1619 H  HG2    . LYS C 3 42 ? 12.39239  8.91305   11.59466  1.000 17.28693 ? 206 LYS F HG2    1 
ATOM   1620 H  HG3    . LYS C 3 42 ? 11.13681  8.31440   10.82620  1.000 17.28693 ? 206 LYS F HG3    1 
ATOM   1621 H  HD2    . LYS C 3 42 ? 12.26179  6.23715   10.73589  1.000 13.45248 ? 206 LYS F HD2    1 
ATOM   1622 H  HD3    . LYS C 3 42 ? 13.39671  6.86023   11.65736  1.000 13.45248 ? 206 LYS F HD3    1 
ATOM   1623 H  HE2    . LYS C 3 42 ? 10.73335  6.46609   12.44544  1.000 18.23262 ? 206 LYS F HE2    1 
ATOM   1624 H  HE3    . LYS C 3 42 ? 11.96843  5.59631   12.93886  1.000 18.23262 ? 206 LYS F HE3    1 
ATOM   1625 H  HZ1    . LYS C 3 42 ? 11.41189  7.13087   14.51591  1.000 24.86268 ? 206 LYS F HZ1    1 
ATOM   1626 H  HZ2    . LYS C 3 42 ? 12.73899  7.44886   14.03010  1.000 24.86268 ? 206 LYS F HZ2    1 
ATOM   1627 H  HZ3    . LYS C 3 42 ? 11.60073  8.23024   13.59177  1.000 24.86268 ? 206 LYS F HZ3    1 
ATOM   1628 N  N      . GLU C 3 43 ? 10.66540  11.10610  9.93894   1.000 11.18770 ? 207 GLU F N      1 
ATOM   1629 C  CA     . GLU C 3 43 ? 9.27150   11.50432  9.72952   1.000 14.23082 ? 207 GLU F CA     1 
ATOM   1630 C  C      . GLU C 3 43 ? 9.13564   12.54299  8.62446   1.000 12.30045 ? 207 GLU F C      1 
ATOM   1631 O  O      . GLU C 3 43 ? 8.14888   12.52324  7.88393   1.000 13.03765 ? 207 GLU F O      1 
ATOM   1632 C  CB     . GLU C 3 43 ? 8.65366   12.02627  11.02368  1.000 16.20169 ? 207 GLU F CB     1 
ATOM   1633 C  CG     . GLU C 3 43 ? 8.50171   10.99430  12.14521  1.000 19.32318 ? 207 GLU F CG     1 
ATOM   1634 C  CD     . GLU C 3 43 ? 7.58128   9.80469   11.80313  1.000 18.98519 ? 207 GLU F CD     1 
ATOM   1635 O  OE1    . GLU C 3 43 ? 6.79360   9.87252   10.84009  1.000 17.99900 ? 207 GLU F OE1    1 
ATOM   1636 O  OE2    . GLU C 3 43 ? 7.63642   8.80098   12.53476  1.000 28.00332 ? 207 GLU F OE2    1 
ATOM   1637 H  H      . GLU C 3 43 ? 10.99632  11.28243  10.71289  1.000 13.42525 ? 207 GLU F H      1 
ATOM   1638 H  HA     . GLU C 3 43 ? 8.77822   10.71351  9.46081   1.000 17.07699 ? 207 GLU F HA     1 
ATOM   1639 H  HB2    . GLU C 3 43 ? 9.21497   12.74086  11.36308  1.000 19.44203 ? 207 GLU F HB2    1 
ATOM   1640 H  HB3    . GLU C 3 43 ? 7.76791   12.36700  10.82302  1.000 19.44203 ? 207 GLU F HB3    1 
ATOM   1641 H  HG2    . GLU C 3 43 ? 9.37784   10.63474  12.35499  1.000 23.18782 ? 207 GLU F HG2    1 
ATOM   1642 H  HG3    . GLU C 3 43 ? 8.12959   11.43693  12.92400  1.000 23.18782 ? 207 GLU F HG3    1 
ATOM   1643 N  N      . ALA C 3 44 ? 10.10714  13.45465  8.48667   1.000 15.96049 ? 208 ALA F N      1 
ATOM   1644 C  CA     . ALA C 3 44 ? 10.03207  14.45592  7.42374   1.000 13.90064 ? 208 ALA F CA     1 
ATOM   1645 C  C      . ALA C 3 44 ? 10.05529  13.80122  6.05061   1.000 13.95307 ? 208 ALA F C      1 
ATOM   1646 O  O      . ALA C 3 44 ? 9.38163   14.25911  5.11773   1.000 13.97450 ? 208 ALA F O      1 
ATOM   1647 C  CB     . ALA C 3 44 ? 11.19111  15.45132  7.55168   1.000 17.06371 ? 208 ALA F CB     1 
ATOM   1648 H  H      . ALA C 3 44 ? 10.80481  13.51185  8.98626   1.000 19.15259 ? 208 ALA F H      1 
ATOM   1649 H  HA     . ALA C 3 44 ? 9.19949   14.94473  7.51741   1.000 16.68077 ? 208 ALA F HA     1 
ATOM   1650 H  HB1    . ALA C 3 44 ? 11.10149  16.13037  6.86483   1.000 20.47646 ? 208 ALA F HB1    1 
ATOM   1651 H  HB2    . ALA C 3 44 ? 11.15877  15.86255  8.42960   1.000 20.47646 ? 208 ALA F HB2    1 
ATOM   1652 H  HB3    . ALA C 3 44 ? 12.02930  14.97614  7.43966   1.000 20.47646 ? 208 ALA F HB3    1 
ATOM   1653 N  N      . LEU C 3 45 ? 10.82337  12.72477  5.91667   1.000 13.06687 ? 209 LEU F N      1 
ATOM   1654 C  CA     . LEU C 3 45 ? 10.84969  11.98475  4.66577   1.000 10.82329 ? 209 LEU F CA     1 
ATOM   1655 C  C      . LEU C 3 45 ? 9.53122   11.24259  4.44789   1.000 10.88625 ? 209 LEU F C      1 
ATOM   1656 O  O      . LEU C 3 45 ? 8.97345   11.27513  3.34765   1.000 13.50647 ? 209 LEU F O      1 
ATOM   1657 C  CB     . LEU C 3 45 ? 12.05349  11.03730  4.67749   1.000 12.65869 ? 209 LEU F CB     1 
ATOM   1658 C  CG     . LEU C 3 45 ? 12.33410  10.14725  3.46624   1.000 13.40747 ? 209 LEU F CG     1 
ATOM   1659 C  CD1    . LEU C 3 45 ? 13.78551  9.68319   3.50519   1.000 13.33761 ? 209 LEU F CD1    1 
ATOM   1660 C  CD2    . LEU C 3 45 ? 11.42562  8.94148   3.41824   1.000 13.05642 ? 209 LEU F CD2    1 
ATOM   1661 H  H      . LEU C 3 45 ? 11.33406  12.40565  6.53065   1.000 15.68025 ? 209 LEU F H      1 
ATOM   1662 H  HA     . LEU C 3 45 ? 10.95942  12.58850  3.91454   1.000 12.98795 ? 209 LEU F HA     1 
ATOM   1663 H  HB2    . LEU C 3 45 ? 12.84633  11.58207  4.80206   1.000 15.19043 ? 209 LEU F HB2    1 
ATOM   1664 H  HB3    . LEU C 3 45 ? 11.94030  10.43871  5.43232   1.000 15.19043 ? 209 LEU F HB3    1 
ATOM   1665 H  HG     . LEU C 3 45 ? 12.16713  10.66701  2.66445   1.000 16.08897 ? 209 LEU F HG     1 
ATOM   1666 H  HD11   . LEU C 3 45 ? 13.95563  9.11364   2.73866   1.000 16.00513 ? 209 LEU F HD11   1 
ATOM   1667 H  HD12   . LEU C 3 45 ? 14.36620  10.45960  3.47576   1.000 16.00513 ? 209 LEU F HD12   1 
ATOM   1668 H  HD13   . LEU C 3 45 ? 13.93679  9.18788   4.32537   1.000 16.00513 ? 209 LEU F HD13   1 
ATOM   1669 H  HD21   . LEU C 3 45 ? 11.82119  8.27087   2.83971   1.000 15.66771 ? 209 LEU F HD21   1 
ATOM   1670 H  HD22   . LEU C 3 45 ? 11.32442  8.58642   4.31523   1.000 15.66771 ? 209 LEU F HD22   1 
ATOM   1671 H  HD23   . LEU C 3 45 ? 10.56143  9.21088   3.06968   1.000 15.66771 ? 209 LEU F HD23   1 
ATOM   1672 N  N      . ALA C 3 46 ? 8.99641   10.60983  5.49450   1.000 11.95207 ? 210 ALA F N      1 
ATOM   1673 C  CA     . ALA C 3 46 ? 7.68423   9.98541   5.37716   1.000 12.98580 ? 210 ALA F CA     1 
ATOM   1674 C  C      . ALA C 3 46 ? 6.64190   11.00178  4.93528   1.000 14.75644 ? 210 ALA F C      1 
ATOM   1675 O  O      . ALA C 3 46 ? 5.82216   10.71909  4.04993   1.000 11.72102 ? 210 ALA F O      1 
ATOM   1676 C  CB     . ALA C 3 46 ? 7.28629   9.33942   6.70107   1.000 12.02547 ? 210 ALA F CB     1 
ATOM   1677 H  H      . ALA C 3 46 ? 9.36672   10.53063  6.26664   1.000 14.34249 ? 210 ALA F H      1 
ATOM   1678 H  HA     . ALA C 3 46 ? 7.72533   9.28262   4.70987   1.000 15.58296 ? 210 ALA F HA     1 
ATOM   1679 H  HB1    . ALA C 3 46 ? 6.40945   8.93600   6.60465   1.000 14.43057 ? 210 ALA F HB1    1 
ATOM   1680 H  HB2    . ALA C 3 46 ? 7.93965   8.65997   6.92991   1.000 14.43057 ? 210 ALA F HB2    1 
ATOM   1681 H  HB3    . ALA C 3 46 ? 7.26270   10.02121  7.39064   1.000 14.43057 ? 210 ALA F HB3    1 
ATOM   1682 N  N      . HIS C 3 47 ? 6.68195   12.21063  5.50869   1.000 14.95689 ? 211 HIS F N      1 
ATOM   1683 C  CA     . HIS C 3 47 ? 5.71605   13.23374  5.12030   1.000 14.62052 ? 211 HIS F CA     1 
ATOM   1684 C  C      . HIS C 3 47 ? 5.80525   13.53635  3.63238   1.000 13.29875 ? 211 HIS F C      1 
ATOM   1685 O  O      . HIS C 3 47 ? 4.78001   13.66837  2.95193   1.000 17.73087 ? 211 HIS F O      1 
ATOM   1686 C  CB     . HIS C 3 47 ? 5.93754   14.51056  5.93767   1.000 15.64776 ? 211 HIS F CB     1 
ATOM   1687 C  CG     . HIS C 3 47 ? 5.65837   14.35217  7.39719   1.000 17.73302 ? 211 HIS F CG     1 
ATOM   1688 N  ND1    . HIS C 3 47 ? 6.17469   15.20656  8.34691   1.000 19.25039 ? 211 HIS F ND1    1 
ATOM   1689 C  CD2    . HIS C 3 47 ? 4.90246   13.45497  8.07241   1.000 19.26956 ? 211 HIS F CD2    1 
ATOM   1690 C  CE1    . HIS C 3 47 ? 5.76669   14.82877  9.54602   1.000 24.21198 ? 211 HIS F CE1    1 
ATOM   1691 N  NE2    . HIS C 3 47 ? 4.98686   13.77259  9.40758   1.000 21.32238 ? 211 HIS F NE2    1 
ATOM   1692 H  H      . HIS C 3 47 ? 7.24597   12.45470  6.11028   1.000 17.94826 ? 211 HIS F H      1 
ATOM   1693 H  HA     . HIS C 3 47 ? 4.82351   12.90569  5.31172   1.000 17.54463 ? 211 HIS F HA     1 
ATOM   1694 H  HB2    . HIS C 3 47 ? 6.86311   14.78459  5.84211   1.000 18.77731 ? 211 HIS F HB2    1 
ATOM   1695 H  HB3    . HIS C 3 47 ? 5.34967   15.20336  5.59807   1.000 18.77731 ? 211 HIS F HB3    1 
ATOM   1696 H  HD1    . HIS C 3 47 ? 6.68332   15.88079  8.18471   1.000 23.10047 ? 211 HIS F HD1    1 
ATOM   1697 H  HD2    . HIS C 3 47 ? 4.41634   12.75395  7.70207   1.000 23.12347 ? 211 HIS F HD2    1 
ATOM   1698 H  HE1    . HIS C 3 47 ? 5.99092   15.23760  10.35068  1.000 29.05437 ? 211 HIS F HE1    1 
ATOM   1699 N  N      . ARG C 3 48 ? 7.02908   13.63774  3.11335   1.000 13.65403 ? 212 ARG F N      1 
ATOM   1700 C  CA     A ARG C 3 48 ? 7.21076   13.93541  1.69682   0.482 16.49855 ? 212 ARG F CA     1 
ATOM   1701 C  CA     B ARG C 3 48 ? 7.20816   13.93591  1.69601   0.518 16.49426 ? 212 ARG F CA     1 
ATOM   1702 C  C      . ARG C 3 48 ? 6.63889   12.82096  0.81977   1.000 14.70876 ? 212 ARG F C      1 
ATOM   1703 O  O      . ARG C 3 48 ? 6.06546   13.09685  -0.23723  1.000 16.72142 ? 212 ARG F O      1 
ATOM   1704 C  CB     A ARG C 3 48 ? 8.70077   14.14752  1.41725   0.482 20.44345 ? 212 ARG F CB     1 
ATOM   1705 C  CB     B ARG C 3 48 ? 8.69335   14.15222  1.39765   0.518 20.45311 ? 212 ARG F CB     1 
ATOM   1706 C  CG     A ARG C 3 48 ? 9.04302   14.38661  -0.03277  0.482 19.92726 ? 212 ARG F CG     1 
ATOM   1707 C  CG     B ARG C 3 48 ? 8.97731   14.44495  -0.06421  0.518 19.90811 ? 212 ARG F CG     1 
ATOM   1708 C  CD     A ARG C 3 48 ? 10.51099  14.73063  -0.16335  0.482 24.71779 ? 212 ARG F CD     1 
ATOM   1709 C  CD     B ARG C 3 48 ? 10.43619  14.78910  -0.28718  0.518 24.86210 ? 212 ARG F CD     1 
ATOM   1710 N  NE     A ARG C 3 48 ? 10.92239  14.84397  -1.55572  0.482 25.83423 ? 212 ARG F NE     1 
ATOM   1711 N  NE     B ARG C 3 48 ? 10.85719  15.94167  0.50208   0.518 24.55351 ? 212 ARG F NE     1 
ATOM   1712 C  CZ     A ARG C 3 48 ? 12.07651  15.35709  -1.95867  0.482 23.45844 ? 212 ARG F CZ     1 
ATOM   1713 C  CZ     B ARG C 3 48 ? 11.94546  16.66012  0.26087   0.518 25.89082 ? 212 ARG F CZ     1 
ATOM   1714 N  NH1    A ARG C 3 48 ? 12.95018  15.85544  -1.10156  0.482 26.34322 ? 212 ARG F NH1    1 
ATOM   1715 N  NH1    B ARG C 3 48 ? 12.69729  16.43808  -0.80533  0.518 26.06452 ? 212 ARG F NH1    1 
ATOM   1716 N  NH2    A ARG C 3 48 ? 12.35712  15.37568  -3.25611  0.482 19.44366 ? 212 ARG F NH2    1 
ATOM   1717 N  NH2    B ARG C 3 48 ? 12.29061  17.62144  1.11462   0.518 14.74923 ? 212 ARG F NH2    1 
ATOM   1718 H  H      . ARG C 3 48 ? 7.76282   13.54031  3.55121   1.000 16.38484 ? 212 ARG F H      1 
ATOM   1719 H  HA     . ARG C 3 48 ? 6.73839   14.75207  1.47135   1.000 19.79312 ? 212 ARG F HA     1 
ATOM   1720 H  HB2    A ARG C 3 48 ? 9.00140   14.92093  1.91960   0.482 24.53214 ? 212 ARG F HB2    1 
ATOM   1721 H  HB2    B ARG C 3 48 ? 9.01123   14.90562  1.91942   0.518 24.54373 ? 212 ARG F HB2    1 
ATOM   1722 H  HB3    A ARG C 3 48 ? 9.18372   13.35696  1.70476   0.482 24.53214 ? 212 ARG F HB3    1 
ATOM   1723 H  HB3    B ARG C 3 48 ? 9.18185   13.35036  1.64113   0.518 24.54373 ? 212 ARG F HB3    1 
ATOM   1724 H  HG2    A ARG C 3 48 ? 8.86347   13.58485  -0.54837  0.482 23.91272 ? 212 ARG F HG2    1 
ATOM   1725 H  HG2    B ARG C 3 48 ? 8.76371   13.66246  -0.59617  0.518 23.88974 ? 212 ARG F HG2    1 
ATOM   1726 H  HG3    A ARG C 3 48 ? 8.51758   15.12628  -0.37585  0.482 23.91272 ? 212 ARG F HG3    1 
ATOM   1727 H  HG3    B ARG C 3 48 ? 8.43867   15.19869  -0.35169  0.518 23.88974 ? 212 ARG F HG3    1 
ATOM   1728 H  HD2    A ARG C 3 48 ? 10.67976  15.58051  0.27267   0.482 29.66135 ? 212 ARG F HD2    1 
ATOM   1729 H  HD2    B ARG C 3 48 ? 10.98488  14.03114  -0.03157  0.518 29.83452 ? 212 ARG F HD2    1 
ATOM   1730 H  HD3    A ARG C 3 48 ? 11.04070  14.03301  0.25335   0.482 29.66135 ? 212 ARG F HD3    1 
ATOM   1731 H  HD3    B ARG C 3 48 ? 10.57454  14.99780  -1.22431  0.518 29.83452 ? 212 ARG F HD3    1 
ATOM   1732 H  HE     A ARG C 3 48 ? 10.37919  14.55833  -2.15816  0.482 31.00108 ? 212 ARG F HE     1 
ATOM   1733 H  HE     B ARG C 3 48 ? 10.36584  16.17091  1.16963   0.518 29.46422 ? 212 ARG F HE     1 
ATOM   1734 H  HH11   A ARG C 3 48 ? 12.77626  15.85203  -0.25934  0.482 31.61186 ? 212 ARG F HH11   1 
ATOM   1735 H  HH11   B ARG C 3 48 ? 12.48395  15.81649  -1.36004  0.518 31.27742 ? 212 ARG F HH11   1 
ATOM   1736 H  HH12   A ARG C 3 48 ? 13.69267  16.18317  -1.38599  0.482 31.61186 ? 212 ARG F HH12   1 
ATOM   1737 H  HH12   B ARG C 3 48 ? 13.39921  16.91538  -0.94349  0.518 31.27742 ? 212 ARG F HH12   1 
ATOM   1738 H  HH21   A ARG C 3 48 ? 11.79359  15.05758  -3.82253  0.482 23.33239 ? 212 ARG F HH21   1 
ATOM   1739 H  HH21   B ARG C 3 48 ? 11.80994  17.77005  1.81210   0.518 17.69907 ? 212 ARG F HH21   1 
ATOM   1740 H  HH22   A ARG C 3 48 ? 13.10244  15.70582  -3.53017  0.482 23.33239 ? 212 ARG F HH22   1 
ATOM   1741 H  HH22   B ARG C 3 48 ? 12.99425  18.09387  0.96869   0.518 17.69907 ? 212 ARG F HH22   1 
ATOM   1742 N  N      . TRP C 3 49 ? 6.80636   11.56370  1.23301   1.000 13.57579 ? 213 TRP F N      1 
ATOM   1743 C  CA     . TRP C 3 49 ? 6.23553   10.44445  0.47882   1.000 11.62378 ? 213 TRP F CA     1 
ATOM   1744 C  C      . TRP C 3 49 ? 4.72132   10.57901  0.37093   1.000 11.39612 ? 213 TRP F C      1 
ATOM   1745 O  O      . TRP C 3 49 ? 4.13826   10.42707  -0.71302  1.000 12.91509 ? 213 TRP F O      1 
ATOM   1746 C  CB     . TRP C 3 49 ? 6.60965   9.12370   1.16058   1.000 12.19410 ? 213 TRP F CB     1 
ATOM   1747 C  CG     . TRP C 3 49 ? 5.88138   7.91423   0.64159   1.000 10.91256 ? 213 TRP F CG     1 
ATOM   1748 C  CD1    . TRP C 3 49 ? 5.14350   7.02333   1.37572   1.000 14.56429 ? 213 TRP F CD1    1 
ATOM   1749 C  CD2    . TRP C 3 49 ? 5.83607   7.45039   -0.71378  1.000 9.49953  ? 213 TRP F CD2    1 
ATOM   1750 N  NE1    . TRP C 3 49 ? 4.64561   6.03493   0.55552   1.000 10.08795 ? 213 TRP F NE1    1 
ATOM   1751 C  CE2    . TRP C 3 49 ? 5.04230   6.28424   -0.73069  1.000 8.73291  ? 213 TRP F CE2    1 
ATOM   1752 C  CE3    . TRP C 3 49 ? 6.37915   7.91278   -1.91548  1.000 11.33658 ? 213 TRP F CE3    1 
ATOM   1753 C  CZ2    . TRP C 3 49 ? 4.78686   5.56751   -1.91125  1.000 12.25541 ? 213 TRP F CZ2    1 
ATOM   1754 C  CZ3    . TRP C 3 49 ? 6.11092   7.19065   -3.10153  1.000 15.08145 ? 213 TRP F CZ3    1 
ATOM   1755 C  CH2    . TRP C 3 49 ? 5.33793   6.03311   -3.07264  1.000 12.68932 ? 213 TRP F CH2    1 
ATOM   1756 H  H      . TRP C 3 49 ? 7.24090   11.33260  1.93825   1.000 16.29095 ? 213 TRP F H      1 
ATOM   1757 H  HA     . TRP C 3 49 ? 6.60420   10.44274  -0.41839  1.000 13.94853 ? 213 TRP F HA     1 
ATOM   1758 H  HB2    . TRP C 3 49 ? 7.55863   8.96939   1.03207   1.000 14.63292 ? 213 TRP F HB2    1 
ATOM   1759 H  HB3    . TRP C 3 49 ? 6.41097   9.19918   2.10701   1.000 14.63292 ? 213 TRP F HB3    1 
ATOM   1760 H  HD1    . TRP C 3 49 ? 4.99989   7.07787   2.29295   1.000 17.47714 ? 213 TRP F HD1    1 
ATOM   1761 H  HE1    . TRP C 3 49 ? 4.16394   5.36951   0.81009   1.000 12.10554 ? 213 TRP F HE1    1 
ATOM   1762 H  HE3    . TRP C 3 49 ? 6.90576   8.67908   -1.93488  1.000 13.60390 ? 213 TRP F HE3    1 
ATOM   1763 H  HZ2    . TRP C 3 49 ? 4.26002   4.80117   -1.90323  1.000 14.70649 ? 213 TRP F HZ2    1 
ATOM   1764 H  HZ3    . TRP C 3 49 ? 6.45520   7.49281   -3.91089  1.000 18.09774 ? 213 TRP F HZ3    1 
ATOM   1765 H  HH2    . TRP C 3 49 ? 5.19282   5.56492   -3.86298  1.000 15.22718 ? 213 TRP F HH2    1 
ATOM   1766 N  N      . GLY C 3 50 ? 4.06584   10.88846  1.49002   1.000 13.87225 ? 214 GLY F N      1 
ATOM   1767 C  CA     . GLY C 3 50 ? 2.61729   10.98523  1.48188   1.000 13.93550 ? 214 GLY F CA     1 
ATOM   1768 C  C      . GLY C 3 50 ? 2.14684   12.13254  0.61367   1.000 19.55015 ? 214 GLY F C      1 
ATOM   1769 O  O      . GLY C 3 50 ? 1.15415   12.01473  -0.11261  1.000 17.18241 ? 214 GLY F O      1 
ATOM   1770 H  H      . GLY C 3 50 ? 4.43346   11.04366  2.25184   1.000 16.64670 ? 214 GLY F H      1 
ATOM   1771 H  HA2    . GLY C 3 50 ? 2.23836   10.16087  1.13874   1.000 16.72260 ? 214 GLY F HA2    1 
ATOM   1772 H  HA3    . GLY C 3 50 ? 2.29597   11.12823  2.38587   1.000 16.72260 ? 214 GLY F HA3    1 
ATOM   1773 N  N      . ILE C 3 51 ? 2.86986   13.24568  0.65820   1.000 15.44030 ? 215 ILE F N      1 
ATOM   1774 C  CA     . ILE C 3 51 ? 2.51987   14.38424  -0.18371  1.000 15.21629 ? 215 ILE F CA     1 
ATOM   1775 C  C      . ILE C 3 51 ? 2.75510   14.05341  -1.65031  1.000 17.22069 ? 215 ILE F C      1 
ATOM   1776 O  O      . ILE C 3 51 ? 1.92348   14.37412  -2.50902  1.000 20.54494 ? 215 ILE F O      1 
ATOM   1777 C  CB     . ILE C 3 51 ? 3.29275   15.63497  0.27790   1.000 20.02940 ? 215 ILE F CB     1 
ATOM   1778 C  CG1    . ILE C 3 51 ? 2.68614   16.13958  1.59819   1.000 29.18672 ? 215 ILE F CG1    1 
ATOM   1779 C  CG2    . ILE C 3 51 ? 3.30472   16.72414  -0.81654  1.000 23.55016 ? 215 ILE F CG2    1 
ATOM   1780 C  CD1    . ILE C 3 51 ? 3.55320   17.11350  2.33902   1.000 37.63763 ? 215 ILE F CD1    1 
ATOM   1781 H  H      . ILE C 3 51 ? 3.55808   13.36706  1.15942   1.000 18.52836 ? 215 ILE F H      1 
ATOM   1782 H  HA     . ILE C 3 51 ? 1.57397   14.57519  -0.08519  1.000 18.25954 ? 215 ILE F HA     1 
ATOM   1783 H  HB     . ILE C 3 51 ? 4.22065   15.39995  0.43491   1.000 24.03528 ? 215 ILE F HB     1 
ATOM   1784 H  HG12   . ILE C 3 51 ? 1.84526   16.58248  1.40414   1.000 35.02406 ? 215 ILE F HG12   1 
ATOM   1785 H  HG13   . ILE C 3 51 ? 2.53382   15.37892  2.18050   1.000 35.02406 ? 215 ILE F HG13   1 
ATOM   1786 H  HG21   . ILE C 3 51 ? 3.59830   17.56177  -0.42529  1.000 28.26019 ? 215 ILE F HG21   1 
ATOM   1787 H  HG22   . ILE C 3 51 ? 3.91477   16.45662  -1.52165  1.000 28.26019 ? 215 ILE F HG22   1 
ATOM   1788 H  HG23   . ILE C 3 51 ? 2.40842   16.82230  -1.17421  1.000 28.26019 ? 215 ILE F HG23   1 
ATOM   1789 H  HD11   . ILE C 3 51 ? 3.14412   17.31226  3.19579   1.000 45.16515 ? 215 ILE F HD11   1 
ATOM   1790 H  HD12   . ILE C 3 51 ? 4.42842   16.71777  2.47422   1.000 45.16515 ? 215 ILE F HD12   1 
ATOM   1791 H  HD13   . ILE C 3 51 ? 3.63478   17.92573  1.81506   1.000 45.16515 ? 215 ILE F HD13   1 
ATOM   1792 N  N      . GLN C 3 52 ? 3.85939   13.37775  -1.96707  1.000 17.18667 ? 216 GLN F N      1 
ATOM   1793 C  CA     . GLN C 3 52 ? 4.09162   12.99796  -3.35676  1.000 16.88829 ? 216 GLN F CA     1 
ATOM   1794 C  C      . GLN C 3 52 ? 2.96249   12.11826  -3.87380  1.000 21.08508 ? 216 GLN F C      1 
ATOM   1795 O  O      . GLN C 3 52 ? 2.54857   12.24417  -5.02926  1.000 19.04231 ? 216 GLN F O      1 
ATOM   1796 C  CB     . GLN C 3 52 ? 5.42932   12.28462  -3.50057  1.000 16.17178 ? 216 GLN F CB     1 
ATOM   1797 C  CG     . GLN C 3 52 ? 5.81703   12.07077  -4.94601  0.984 32.13246 ? 216 GLN F CG     1 
ATOM   1798 C  CD     . GLN C 3 52 ? 7.27935   11.79621  -5.14057  0.798 32.37280 ? 216 GLN F CD     1 
ATOM   1799 O  OE1    . GLN C 3 52 ? 7.65754   10.87899  -5.87305  0.560 26.35814 ? 216 GLN F OE1    1 
ATOM   1800 N  NE2    . GLN C 3 52 ? 8.11875   12.59485  -4.49836  0.888 27.78004 ? 216 GLN F NE2    1 
ATOM   1801 H  H      . GLN C 3 52 ? 4.47063   13.13480  -1.41303  1.000 20.62400 ? 216 GLN F H      1 
ATOM   1802 H  HA     . GLN C 3 52 ? 4.12819   13.80316  -3.89640  0.716 20.26595 ? 216 GLN F HA     1 
ATOM   1803 H  HB2    . GLN C 3 52 ? 6.12030   12.81896  -3.07876  1.000 19.40614 ? 216 GLN F HB2    1 
ATOM   1804 H  HB3    . GLN C 3 52 ? 5.37315   11.41642  -3.07166  1.000 19.40614 ? 216 GLN F HB3    1 
ATOM   1805 H  HG2    . GLN C 3 52 ? 5.32394   11.31102  -5.29321  1.000 38.55895 ? 216 GLN F HG2    1 
ATOM   1806 H  HG3    . GLN C 3 52 ? 5.59546   12.86885  -5.45086  1.000 38.55895 ? 216 GLN F HG3    1 
ATOM   1807 H  HE21   . GLN C 3 52 ? 7.81511   13.22891  -4.00302  1.000 33.33604 ? 216 GLN F HE21   1 
ATOM   1808 H  HE22   . GLN C 3 52 ? 8.96733   12.47925  -4.57678  0.934 33.33604 ? 216 GLN F HE22   1 
ATOM   1809 N  N      . LYS C 3 53 ? 2.42853   11.24891  -3.01948  1.000 17.67286 ? 217 LYS F N      1 
ATOM   1810 C  CA     . LYS C 3 53 ? 1.35137   10.34380  -3.38993  1.000 16.74098 ? 217 LYS F CA     1 
ATOM   1811 C  C      . LYS C 3 53 ? -0.01844  10.99840  -3.38649  1.000 16.55308 ? 217 LYS F C      1 
ATOM   1812 O  O      . LYS C 3 53 ? -0.95290  10.42561  -3.94512  1.000 18.96289 ? 217 LYS F O      1 
ATOM   1813 C  CB     . LYS C 3 53 ? 1.33575   9.15678   -2.42587  1.000 14.35494 ? 217 LYS F CB     1 
ATOM   1814 C  CG     . LYS C 3 53 ? 2.42848   8.12058   -2.70983  1.000 12.40936 ? 217 LYS F CG     1 
ATOM   1815 C  CD     . LYS C 3 53 ? 2.25335   7.37486   -4.03665  1.000 15.31010 ? 217 LYS F CD     1 
ATOM   1816 C  CE     . LYS C 3 53 ? 0.99609   6.51634   -4.09046  1.000 16.82236 ? 217 LYS F CE     1 
ATOM   1817 N  NZ     . LYS C 3 53 ? 1.05769   5.37809   -3.12413  1.000 13.00485 ? 217 LYS F NZ     1 
ATOM   1818 H  H      . LYS C 3 53 ? 2.67945   11.16317  -2.20138  1.000 21.20744 ? 217 LYS F H      1 
ATOM   1819 H  HA     . LYS C 3 53 ? 1.51762   10.02370  -4.29037  1.000 20.08917 ? 217 LYS F HA     1 
ATOM   1820 H  HB2    . LYS C 3 53 ? 1.46657   9.48607   -1.52290  1.000 17.22593 ? 217 LYS F HB2    1 
ATOM   1821 H  HB3    . LYS C 3 53 ? 0.47772   8.70966   -2.49490  1.000 17.22593 ? 217 LYS F HB3    1 
ATOM   1822 H  HG2    . LYS C 3 53 ? 3.28638   8.57239   -2.73769  1.000 14.89124 ? 217 LYS F HG2    1 
ATOM   1823 H  HG3    . LYS C 3 53 ? 2.42404   7.46058   -1.99899  1.000 14.89124 ? 217 LYS F HG3    1 
ATOM   1824 H  HD2    . LYS C 3 53 ? 2.20028   8.02329   -4.75611  1.000 18.37212 ? 217 LYS F HD2    1 
ATOM   1825 H  HD3    . LYS C 3 53 ? 3.01644   6.79142   -4.17148  1.000 18.37212 ? 217 LYS F HD3    1 
ATOM   1826 H  HE2    . LYS C 3 53 ? 0.22616   7.06254   -3.86737  1.000 20.18683 ? 217 LYS F HE2    1 
ATOM   1827 H  HE3    . LYS C 3 53 ? 0.89625   6.15120   -4.98355  1.000 20.18683 ? 217 LYS F HE3    1 
ATOM   1828 H  HZ1    . LYS C 3 53 ? 1.71481   4.82205   -3.35024  1.000 15.60582 ? 217 LYS F HZ1    1 
ATOM   1829 H  HZ2    . LYS C 3 53 ? 1.20849   5.68438   -2.30222  1.000 15.60582 ? 217 LYS F HZ2    1 
ATOM   1830 H  HZ3    . LYS C 3 53 ? 0.28742   4.93226   -3.12943  1.000 15.60582 ? 217 LYS F HZ3    1 
ATOM   1831 N  N      . GLY C 3 54 ? -0.16369  12.15837  -2.75245  1.000 18.29070 ? 218 GLY F N      1 
ATOM   1832 C  CA     . GLY C 3 54 ? -1.47697  12.76528  -2.62242  1.000 21.01498 ? 218 GLY F CA     1 
ATOM   1833 C  C      . GLY C 3 54 ? -2.41216  11.98215  -1.73048  1.000 19.52076 ? 218 GLY F C      1 
ATOM   1834 O  O      . GLY C 3 54 ? -3.62409  12.01476  -1.93363  1.000 19.97194 ? 218 GLY F O      1 
ATOM   1835 H  H      . GLY C 3 54 ? 0.47659   12.60674  -2.39384  1.000 21.94884 ? 218 GLY F H      1 
ATOM   1836 H  HA2    . GLY C 3 54 ? -1.37910  13.65563  -2.25014  1.000 25.21798 ? 218 GLY F HA2    1 
ATOM   1837 H  HA3    . GLY C 3 54 ? -1.88305  12.83309  -3.50071  1.000 25.21798 ? 218 GLY F HA3    1 
ATOM   1838 N  N      . ASN C 3 55 ? -1.87883  11.26361  -0.74252  1.000 16.94726 ? 219 ASN F N      1 
ATOM   1839 C  CA     . ASN C 3 55 ? -2.72459  10.45731  0.11380   1.000 16.46761 ? 219 ASN F CA     1 
ATOM   1840 C  C      . ASN C 3 55 ? -3.63161  11.34436  0.95955   1.000 16.76163 ? 219 ASN F C      1 
ATOM   1841 O  O      . ASN C 3 55 ? -3.33171  12.50645  1.23849   1.000 17.61819 ? 219 ASN F O      1 
ATOM   1842 C  CB     . ASN C 3 55 ? -1.87536  9.56842   1.02723   1.000 14.84704 ? 219 ASN F CB     1 
ATOM   1843 C  CG     . ASN C 3 55 ? -1.05307  8.54501   0.24997   1.000 15.08886 ? 219 ASN F CG     1 
ATOM   1844 O  OD1    . ASN C 3 55 ? -1.44898  8.11309   -0.84375  1.000 15.26165 ? 219 ASN F OD1    1 
ATOM   1845 N  ND2    . ASN C 3 55 ? 0.07769   8.12131   0.82443   1.000 14.24967 ? 219 ASN F ND2    1 
ATOM   1846 H  H      . ASN C 3 55 ? -1.04020  11.23058  -0.55488  1.000 20.33671 ? 219 ASN F H      1 
ATOM   1847 H  HA     . ASN C 3 55 ? -3.28127  9.88414   -0.43619  1.000 19.76113 ? 219 ASN F HA     1 
ATOM   1848 H  HB2    . ASN C 3 55 ? -1.26241  10.12625  1.53123   1.000 17.81644 ? 219 ASN F HB2    1 
ATOM   1849 H  HB3    . ASN C 3 55 ? -2.46004  9.08667   1.63301   1.000 17.81644 ? 219 ASN F HB3    1 
ATOM   1850 H  HD21   . ASN C 3 55 ? 0.57380   7.54453   0.42342   1.000 17.09960 ? 219 ASN F HD21   1 
ATOM   1851 H  HD22   . ASN C 3 55 ? 0.30880   8.42559   1.59488   1.000 17.09960 ? 219 ASN F HD22   1 
ATOM   1852 N  N      . ARG C 3 56 ? -4.73806  10.75160  1.40799   0.879 17.68310 ? 220 ARG F N      1 
ATOM   1853 C  CA     . ARG C 3 56 ? -5.71061  11.48292  2.21618   1.000 20.70927 ? 220 ARG F CA     1 
ATOM   1854 C  C      . ARG C 3 56 ? -5.13443  11.88957  3.56547   1.000 21.33749 ? 220 ARG F C      1 
ATOM   1855 O  O      . ARG C 3 56 ? -5.33507  13.02374  4.01830   0.999 21.26997 ? 220 ARG F O      1 
ATOM   1856 C  CB     . ARG C 3 56 ? -6.96285  10.62890  2.41605   1.000 22.54970 ? 220 ARG F CB     1 
ATOM   1857 C  CG     . ARG C 3 56 ? -8.03715  11.33190  3.24674   1.000 26.55213 ? 220 ARG F CG     1 
ATOM   1858 C  CD     . ARG C 3 56 ? -9.26050  10.45454  3.46082   1.000 26.60110 ? 220 ARG F CD     1 
ATOM   1859 N  NE     . ARG C 3 56 ? -8.86473  9.07174   3.67963   0.234 30.14050 ? 220 ARG F NE     1 
ATOM   1860 C  CZ     . ARG C 3 56 ? -8.96505  8.10264   2.78086   0.011 29.87278 ? 220 ARG F CZ     1 
ATOM   1861 N  NH1    . ARG C 3 56 ? -9.62205  8.27211   1.64119   0.432 34.90810 ? 220 ARG F NH1    1 
ATOM   1862 N  NH2    . ARG C 3 56 ? -8.38950  6.93301   3.03234   1.000 29.74949 ? 220 ARG F NH2    1 
ATOM   1863 H  H      . ARG C 3 56 ? -4.94828  9.93107   1.25917   0.983 21.21972 ? 220 ARG F H      1 
ATOM   1864 H  HA     . ARG C 3 56 ? -5.95412  12.29240  1.74042   0.911 24.85112 ? 220 ARG F HA     1 
ATOM   1865 H  HB2    . ARG C 3 56 ? -7.34358  10.42027  1.54863   1.000 27.05964 ? 220 ARG F HB2    1 
ATOM   1866 H  HB3    . ARG C 3 56 ? -6.71627  9.81099   2.87553   1.000 27.05964 ? 220 ARG F HB3    1 
ATOM   1867 H  HG2    . ARG C 3 56 ? -7.67116  11.55759  4.11623   1.000 31.86256 ? 220 ARG F HG2    1 
ATOM   1868 H  HG3    . ARG C 3 56 ? -8.31982  12.13760  2.78649   1.000 31.86256 ? 220 ARG F HG3    1 
ATOM   1869 H  HD2    . ARG C 3 56 ? -9.74922  10.76317  4.23979   1.000 31.92132 ? 220 ARG F HD2    1 
ATOM   1870 H  HD3    . ARG C 3 56 ? -9.82903  10.49284  2.67583   0.841 31.92132 ? 220 ARG F HD3    1 
ATOM   1871 H  HE     . ARG C 3 56 ? -8.54139  8.86778   4.44998   1.000 36.16860 ? 220 ARG F HE     1 
ATOM   1872 H  HH11   . ARG C 3 56 ? -9.99731  9.02658   1.46927   1.000 41.88972 ? 220 ARG F HH11   1 
ATOM   1873 H  HH12   . ARG C 3 56 ? -9.67278  7.62752   1.07415   1.000 41.88972 ? 220 ARG F HH12   1 
ATOM   1874 H  HH21   . ARG C 3 56 ? -7.96067  6.81417   3.76826   1.000 35.69939 ? 220 ARG F HH21   1 
ATOM   1875 H  HH22   . ARG C 3 56 ? -8.44550  6.29417   2.45931   0.850 35.69939 ? 220 ARG F HH22   1 
ATOM   1876 N  N      . LYS C 3 57 ? -4.44716  10.97038  4.24394   1.000 16.93775 ? 221 LYS F N      1 
ATOM   1877 C  CA     . LYS C 3 57 ? -3.91665  11.21983  5.57766   1.000 15.63704 ? 221 LYS F CA     1 
ATOM   1878 C  C      . LYS C 3 57 ? -2.43520  11.56584  5.50290   1.000 15.19694 ? 221 LYS F C      1 
ATOM   1879 O  O      . LYS C 3 57 ? -1.76213  11.31169  4.49984   1.000 16.39900 ? 221 LYS F O      1 
ATOM   1880 C  CB     . LYS C 3 57 ? -4.10590  10.00029  6.49273   1.000 21.15110 ? 221 LYS F CB     1 
ATOM   1881 C  CG     . LYS C 3 57 ? -5.54053  9.46864   6.55956   1.000 28.04090 ? 221 LYS F CG     1 
ATOM   1882 C  CD     . LYS C 3 57 ? -6.28932  10.01482  7.73914   1.000 30.71677 ? 221 LYS F CD     1 
ATOM   1883 C  CE     . LYS C 3 57 ? -7.74732  9.56756   7.70626   1.000 34.99990 ? 221 LYS F CE     1 
ATOM   1884 N  NZ     . LYS C 3 57 ? -8.50447  10.15246  8.83876   1.000 49.66138 ? 221 LYS F NZ     1 
ATOM   1885 H  H      . LYS C 3 57 ? -4.27420  10.18282  3.94488   1.000 20.32529 ? 221 LYS F H      1 
ATOM   1886 H  HA     . LYS C 3 57 ? -4.39716  11.96718  5.96686   1.000 18.76445 ? 221 LYS F HA     1 
ATOM   1887 H  HB2    . LYS C 3 57 ? -3.54228  9.28071   6.16801   1.000 25.38132 ? 221 LYS F HB2    1 
ATOM   1888 H  HB3    . LYS C 3 57 ? -3.84323  10.24684  7.39335   1.000 25.38132 ? 221 LYS F HB3    1 
ATOM   1889 H  HG2    . LYS C 3 57 ? -6.01473  9.72755   5.75396   1.000 33.64907 ? 221 LYS F HG2    1 
ATOM   1890 H  HG3    . LYS C 3 57 ? -5.51943  8.50188   6.63589   1.000 33.64907 ? 221 LYS F HG3    1 
ATOM   1891 H  HD2    . LYS C 3 57 ? -5.88545  9.68926   8.55878   1.000 36.86013 ? 221 LYS F HD2    1 
ATOM   1892 H  HD3    . LYS C 3 57 ? -6.26377  10.98427  7.71900   1.000 36.86013 ? 221 LYS F HD3    1 
ATOM   1893 H  HE2    . LYS C 3 57 ? -8.15726  9.86123   6.87764   1.000 41.99989 ? 221 LYS F HE2    1 
ATOM   1894 H  HE3    . LYS C 3 57 ? -7.79084  8.60088   7.77355   1.000 41.99989 ? 221 LYS F HE3    1 
ATOM   1895 H  HZ1    . LYS C 3 57 ? -9.34926  9.87329   8.81663   1.000 59.59366 ? 221 LYS F HZ1    1 
ATOM   1896 H  HZ2    . LYS C 3 57 ? -8.13814  9.90352   9.61073   1.000 59.59366 ? 221 LYS F HZ2    1 
ATOM   1897 H  HZ3    . LYS C 3 57 ? -8.49238  11.04084  8.78651   1.000 59.59366 ? 221 LYS F HZ3    1 
ATOM   1898 N  N      . LYS C 3 58 ? -1.94475  12.16709  6.58755   1.000 16.43804 ? 222 LYS F N      1 
ATOM   1899 C  CA     . LYS C 3 58 ? -0.51802  12.41569  6.74005   1.000 18.31212 ? 222 LYS F CA     1 
ATOM   1900 C  C      . LYS C 3 58 ? 0.21492   11.08970  6.80251   1.000 15.87347 ? 222 LYS F C      1 
ATOM   1901 O  O      . LYS C 3 58 ? -0.16188  10.19559  7.56278   1.000 16.08503 ? 222 LYS F O      1 
ATOM   1902 C  CB     . LYS C 3 58 ? -0.26207  13.21709  8.01677   1.000 22.07317 ? 222 LYS F CB     1 
ATOM   1903 C  CG     . LYS C 3 58 ? 1.21132   13.43709  8.35836   1.000 24.79676 ? 222 LYS F CG     1 
ATOM   1904 C  CD     . LYS C 3 58 ? 1.37510   14.09756  9.73647   1.000 32.05663 ? 222 LYS F CD     1 
ATOM   1905 C  CE     . LYS C 3 58 ? 1.53841   13.05177  10.84899  1.000 47.32230 ? 222 LYS F CE     1 
ATOM   1906 N  NZ     . LYS C 3 58 ? 1.32932   13.60729  12.22508  1.000 59.27099 ? 222 LYS F NZ     1 
ATOM   1907 H  H      . LYS C 3 58 ? -2.42062  12.44045  7.24968   1.000 19.72565 ? 222 LYS F H      1 
ATOM   1908 H  HA     . LYS C 3 58 ? -0.18559  12.93091  5.98843   1.000 21.97454 ? 222 LYS F HA     1 
ATOM   1909 H  HB2    . LYS C 3 58 ? -0.67101  14.09106  7.91753   1.000 26.48781 ? 222 LYS F HB2    1 
ATOM   1910 H  HB3    . LYS C 3 58 ? -0.66565  12.74461  8.76162   1.000 26.48781 ? 222 LYS F HB3    1 
ATOM   1911 H  HG2    . LYS C 3 58 ? 1.66919   12.58209  8.37329   1.000 29.75612 ? 222 LYS F HG2    1 
ATOM   1912 H  HG3    . LYS C 3 58 ? 1.61282   14.01686  7.69236   1.000 29.75612 ? 222 LYS F HG3    1 
ATOM   1913 H  HD2    . LYS C 3 58 ? 2.16446   14.66128  9.73036   1.000 38.46796 ? 222 LYS F HD2    1 
ATOM   1914 H  HD3    . LYS C 3 58 ? 0.58852   14.63025  9.93253   1.000 38.46796 ? 222 LYS F HD3    1 
ATOM   1915 H  HE2    . LYS C 3 58 ? 0.88864   12.34461  10.71254  1.000 56.78676 ? 222 LYS F HE2    1 
ATOM   1916 H  HE3    . LYS C 3 58 ? 2.43707   12.68886  10.80885  1.000 56.78676 ? 222 LYS F HE3    1 
ATOM   1917 H  HZ1    . LYS C 3 58 ? 1.48146   12.97658  12.83431  1.000 71.12519 ? 222 LYS F HZ1    1 
ATOM   1918 H  HZ2    . LYS C 3 58 ? 1.88666   14.28648  12.36709  1.000 71.12519 ? 222 LYS F HZ2    1 
ATOM   1919 H  HZ3    . LYS C 3 58 ? 0.49244   13.89730  12.31235  1.000 71.12519 ? 222 LYS F HZ3    1 
ATOM   1920 N  N      . MET C 3 59 ? 1.25846   10.95966  5.99475   1.000 15.93572 ? 223 MET F N      1 
ATOM   1921 C  CA     . MET C 3 59 ? 2.07967   9.76024   6.01037   1.000 13.76260 ? 223 MET F CA     1 
ATOM   1922 C  C      . MET C 3 59 ? 3.01380   9.76972   7.21692   1.000 17.71379 ? 223 MET F C      1 
ATOM   1923 O  O      . MET C 3 59 ? 3.54226   10.81346  7.60934   1.000 18.44078 ? 223 MET F O      1 
ATOM   1924 C  CB     . MET C 3 59 ? 2.88203   9.67083   4.71250   1.000 12.94232 ? 223 MET F CB     1 
ATOM   1925 C  CG     . MET C 3 59 ? 3.85495   8.48121   4.62358   1.000 12.75210 ? 223 MET F CG     1 
ATOM   1926 S  SD     . MET C 3 59 ? 3.15336   6.83266   4.87540   1.000 12.79140 ? 223 MET F SD     1 
ATOM   1927 C  CE     . MET C 3 59 ? 1.98818   6.70788   3.50125   1.000 14.05657 ? 223 MET F CE     1 
ATOM   1928 H  H      . MET C 3 59 ? 1.51206   11.55377  5.42701   1.000 19.12286 ? 223 MET F H      1 
ATOM   1929 H  HA     . MET C 3 59 ? 1.51338   8.97487   6.06875   1.000 16.51512 ? 223 MET F HA     1 
ATOM   1930 H  HB2    . MET C 3 59 ? 2.25966   9.59227   3.97265   1.000 15.53079 ? 223 MET F HB2    1 
ATOM   1931 H  HB3    . MET C 3 59 ? 3.40637   10.48167  4.62029   1.000 15.53079 ? 223 MET F HB3    1 
ATOM   1932 H  HG2    . MET C 3 59 ? 4.25521   8.48597   3.74002   1.000 15.30252 ? 223 MET F HG2    1 
ATOM   1933 H  HG3    . MET C 3 59 ? 4.54046   8.60272   5.29900   1.000 15.30252 ? 223 MET F HG3    1 
ATOM   1934 H  HE1    . MET C 3 59 ? 1.56302   5.83637   3.52586   1.000 16.86789 ? 223 MET F HE1    1 
ATOM   1935 H  HE2    . MET C 3 59 ? 1.31938   7.40482   3.59002   1.000 16.86789 ? 223 MET F HE2    1 
ATOM   1936 H  HE3    . MET C 3 59 ? 2.47089   6.81699   2.66700   1.000 16.86789 ? 223 MET F HE3    1 
ATOM   1937 N  N      . THR C 3 60 ? 3.20293   8.60065   7.81599   1.000 12.73068 ? 224 THR F N      1 
ATOM   1938 C  CA     . THR C 3 60 ? 4.09293   8.44151   8.93872   1.000 14.17127 ? 224 THR F CA     1 
ATOM   1939 C  C      . THR C 3 60 ? 5.15178   7.42025   8.57717   1.000 13.71661 ? 224 THR F C      1 
ATOM   1940 O  O      . THR C 3 60 ? 4.96723   6.60006   7.67541   1.000 12.44314 ? 224 THR F O      1 
ATOM   1941 C  CB     . THR C 3 60 ? 3.35326   7.95445   10.17961  1.000 12.38585 ? 224 THR F CB     1 
ATOM   1942 O  OG1    . THR C 3 60 ? 2.83541   6.65403   9.91259   1.000 14.67545 ? 224 THR F OG1    1 
ATOM   1943 C  CG2    . THR C 3 60 ? 2.21461   8.89063   10.54932  1.000 14.81676 ? 224 THR F CG2    1 
ATOM   1944 H  H      . THR C 3 60 ? 2.81351   7.87163   7.57834   1.000 15.27682 ? 224 THR F H      1 
ATOM   1945 H  HA     . THR C 3 60 ? 4.50776   9.29386   9.14443   1.000 17.00552 ? 224 THR F HA     1 
ATOM   1946 H  HB     . THR C 3 60 ? 3.96078   7.92817   10.93534  1.000 14.86302 ? 224 THR F HB     1 
ATOM   1947 H  HG1    . THR C 3 60 ? 2.44014   6.35717   10.59173  1.000 17.61054 ? 224 THR F HG1    1 
ATOM   1948 H  HG21   . THR C 3 60 ? 1.80409   8.60207   11.37944  1.000 17.78012 ? 224 THR F HG21   1 
ATOM   1949 H  HG22   . THR C 3 60 ? 2.55067   9.79361   10.66155  1.000 17.78012 ? 224 THR F HG22   1 
ATOM   1950 H  HG23   . THR C 3 60 ? 1.54337   8.88932   9.84908   1.000 17.78012 ? 224 THR F HG23   1 
ATOM   1951 N  N      . TYR C 3 61 ? 6.25955   7.46466   9.30225   1.000 13.00340 ? 225 TYR F N      1 
ATOM   1952 C  CA     . TYR C 3 61 ? 7.27721   6.44711   9.09559   1.000 13.01173 ? 225 TYR F CA     1 
ATOM   1953 C  C      . TYR C 3 61 ? 6.70382   5.05312   9.33556   1.000 11.65934 ? 225 TYR F C      1 
ATOM   1954 O  O      . TYR C 3 61 ? 7.01911   4.11679   8.60490   1.000 12.28921 ? 225 TYR F O      1 
ATOM   1955 C  CB     . TYR C 3 61 ? 8.48582   6.68668   9.99731   1.000 12.12553 ? 225 TYR F CB     1 
ATOM   1956 C  CG     . TYR C 3 61 ? 9.54170   5.63752   9.74008   1.000 9.76335  ? 225 TYR F CG     1 
ATOM   1957 C  CD1    . TYR C 3 61 ? 10.38285  5.75225   8.64999   1.000 11.17903 ? 225 TYR F CD1    1 
ATOM   1958 C  CD2    . TYR C 3 61 ? 9.65203   4.50673   10.54642  1.000 13.27249 ? 225 TYR F CD2    1 
ATOM   1959 C  CE1    . TYR C 3 61 ? 11.30575  4.78641   8.36910   1.000 10.50522 ? 225 TYR F CE1    1 
ATOM   1960 C  CE2    . TYR C 3 61 ? 10.57952  3.53812   10.28517  1.000 15.84797 ? 225 TYR F CE2    1 
ATOM   1961 C  CZ     . TYR C 3 61 ? 11.41202  3.68935   9.18934   1.000 11.69940 ? 225 TYR F CZ     1 
ATOM   1962 O  OH     . TYR C 3 61 ? 12.33297  2.72020   8.88090   1.000 18.06746 ? 225 TYR F OH     1 
ATOM   1963 H  H      . TYR C 3 61 ? 6.44152   8.05413   9.90143   1.000 15.60408 ? 225 TYR F H      1 
ATOM   1964 H  HA     . TYR C 3 61 ? 7.58619   6.50624   8.17802   1.000 15.61407 ? 225 TYR F HA     1 
ATOM   1965 H  HB2    . TYR C 3 61 ? 8.86324   7.56061   9.81103   1.000 14.55064 ? 225 TYR F HB2    1 
ATOM   1966 H  HB3    . TYR C 3 61 ? 8.21430   6.63389   10.92704  1.000 14.55064 ? 225 TYR F HB3    1 
ATOM   1967 H  HD1    . TYR C 3 61 ? 10.31931  6.49889   8.09918   1.000 13.41484 ? 225 TYR F HD1    1 
ATOM   1968 H  HD2    . TYR C 3 61 ? 9.08374   4.40941   11.27613  1.000 15.92698 ? 225 TYR F HD2    1 
ATOM   1969 H  HE1    . TYR C 3 61 ? 11.85948  4.87055   7.62666   1.000 12.60626 ? 225 TYR F HE1    1 
ATOM   1970 H  HE2    . TYR C 3 61 ? 10.65037  2.79047   10.83371  1.000 19.01756 ? 225 TYR F HE2    1 
ATOM   1971 H  HH     . TYR C 3 61 ? 12.69552  2.89280   8.14309   1.000 21.68095 ? 225 TYR F HH     1 
ATOM   1972 N  N      . GLN C 3 62 ? 5.87957   4.89277   10.37151  1.000 11.86861 ? 226 GLN F N      1 
ATOM   1973 C  CA     A GLN C 3 62 ? 5.31535   3.57747   10.64747  0.462 13.77091 ? 226 GLN F CA     1 
ATOM   1974 C  CA     B GLN C 3 62 ? 5.31711   3.56868   10.64809  0.538 13.76731 ? 226 GLN F CA     1 
ATOM   1975 C  C      . GLN C 3 62 ? 4.55217   3.05128   9.44293   1.000 11.84129 ? 226 GLN F C      1 
ATOM   1976 O  O      . GLN C 3 62 ? 4.71531   1.89267   9.05343   1.000 11.46041 ? 226 GLN F O      1 
ATOM   1977 C  CB     A GLN C 3 62 ? 4.41029   3.65973   11.86844  0.462 15.54417 ? 226 GLN F CB     1 
ATOM   1978 C  CB     B GLN C 3 62 ? 4.39988   3.59548   11.87680  0.538 15.56887 ? 226 GLN F CB     1 
ATOM   1979 C  CG     A GLN C 3 62 ? 3.70064   2.36670   12.16900  0.462 14.23535 ? 226 GLN F CG     1 
ATOM   1980 C  CG     B GLN C 3 62 ? 5.05497   3.26308   13.23833  0.538 18.26361 ? 226 GLN F CG     1 
ATOM   1981 C  CD     A GLN C 3 62 ? 3.01685   2.39940   13.50403  0.462 26.13036 ? 226 GLN F CD     1 
ATOM   1982 C  CD     B GLN C 3 62 ? 5.21668   1.74771   13.56693  0.538 24.60679 ? 226 GLN F CD     1 
ATOM   1983 O  OE1    A GLN C 3 62 ? 3.21615   3.32518   14.28817  0.462 24.14194 ? 226 GLN F OE1    1 
ATOM   1984 O  OE1    B GLN C 3 62 ? 4.67194   0.85410   12.89402  0.538 17.60011 ? 226 GLN F OE1    1 
ATOM   1985 N  NE2    A GLN C 3 62 ? 2.20728   1.38588   13.77965  0.462 23.99100 ? 226 GLN F NE2    1 
ATOM   1986 N  NE2    B GLN C 3 62 ? 5.95882   1.47281   14.63996  0.538 18.94443 ? 226 GLN F NE2    1 
ATOM   1987 H  H      A GLN C 3 62 ? 5.63851   5.51442   10.91470  0.462 14.24234 ? 226 GLN F H      1 
ATOM   1988 H  H      B GLN C 3 62 ? 5.63648   5.51426   10.91397  0.538 14.24234 ? 226 GLN F H      1 
ATOM   1989 H  HA     . GLN C 3 62 ? 6.03273   2.95411   10.84162  1.000 16.52077 ? 226 GLN F HA     1 
ATOM   1990 H  HB2    A GLN C 3 62 ? 4.94720   3.89235   12.64208  0.462 18.65301 ? 226 GLN F HB2    1 
ATOM   1991 H  HB2    B GLN C 3 62 ? 4.02465   4.48676   11.95244  0.538 18.68265 ? 226 GLN F HB2    1 
ATOM   1992 H  HB3    A GLN C 3 62 ? 3.73708   4.34097   11.71484  0.462 18.65301 ? 226 GLN F HB3    1 
ATOM   1993 H  HB3    B GLN C 3 62 ? 3.69129   2.94795   11.73716  0.538 18.68265 ? 226 GLN F HB3    1 
ATOM   1994 H  HG2    A GLN C 3 62 ? 3.02895   2.20546   11.48801  0.462 17.08242 ? 226 GLN F HG2    1 
ATOM   1995 H  HG2    B GLN C 3 62 ? 5.94215   3.65502   13.25209  0.538 21.91633 ? 226 GLN F HG2    1 
ATOM   1996 H  HG3    A GLN C 3 62 ? 4.34604   1.64261   12.17640  0.462 17.08242 ? 226 GLN F HG3    1 
ATOM   1997 H  HG3    B GLN C 3 62 ? 4.50979   3.65143   13.94038  0.538 21.91633 ? 226 GLN F HG3    1 
ATOM   1998 H  HE21   A GLN C 3 62 ? 2.09724   0.75504   13.20560  0.462 28.78920 ? 226 GLN F HE21   1 
ATOM   1999 H  HE21   B GLN C 3 62 ? 6.30889   2.11239   15.09601  0.538 22.73331 ? 226 GLN F HE21   1 
ATOM   2000 H  HE22   A GLN C 3 62 ? 1.79231   1.35944   14.53245  0.462 28.78920 ? 226 GLN F HE22   1 
ATOM   2001 H  HE22   B GLN C 3 62 ? 6.08743   0.65590   14.87602  0.538 22.73331 ? 226 GLN F HE22   1 
ATOM   2002 N  N      . LYS C 3 63 ? 3.71858   3.89375   8.81926   1.000 12.82796 ? 227 LYS F N      1 
ATOM   2003 C  CA     . LYS C 3 63 ? 2.95953   3.42439   7.67057   1.000 10.96768 ? 227 LYS F CA     1 
ATOM   2004 C  C      . LYS C 3 63 ? 3.86618   3.19248   6.47441   1.000 11.91313 ? 227 LYS F C      1 
ATOM   2005 O  O      . LYS C 3 63 ? 3.63550   2.27130   5.68994   1.000 12.36331 ? 227 LYS F O      1 
ATOM   2006 C  CB     . LYS C 3 63 ? 1.86457   4.41504   7.30067   1.000 11.91217 ? 227 LYS F CB     1 
ATOM   2007 C  CG     . LYS C 3 63 ? 0.69700   4.42629   8.26777   1.000 15.77012 ? 227 LYS F CG     1 
ATOM   2008 C  CD     . LYS C 3 63 ? -0.44832  5.28828   7.76754   1.000 13.46307 ? 227 LYS F CD     1 
ATOM   2009 C  CE     . LYS C 3 63 ? -0.12243  6.76566   7.76772   1.000 14.19275 ? 227 LYS F CE     1 
ATOM   2010 N  NZ     . LYS C 3 63 ? -1.26818  7.64146   7.34802   1.000 14.39717 ? 227 LYS F NZ     1 
ATOM   2011 H  H      . LYS C 3 63 ? 3.58309   4.71411   9.03891   1.000 15.39355 ? 227 LYS F H      1 
ATOM   2012 H  HA     . LYS C 3 63 ? 2.53537   2.58657   7.91355   1.000 13.16122 ? 227 LYS F HA     1 
ATOM   2013 H  HB2    . LYS C 3 63 ? 2.24425   5.30750   7.28478   1.000 14.29460 ? 227 LYS F HB2    1 
ATOM   2014 H  HB3    . LYS C 3 63 ? 1.52002   4.18542   6.42348   1.000 14.29460 ? 227 LYS F HB3    1 
ATOM   2015 H  HG2    . LYS C 3 63 ? 0.36742   3.52105   8.38098   1.000 18.92414 ? 227 LYS F HG2    1 
ATOM   2016 H  HG3    . LYS C 3 63 ? 0.99245   4.78091   9.12091   1.000 18.92414 ? 227 LYS F HG3    1 
ATOM   2017 H  HD2    . LYS C 3 63 ? -0.66287  5.03036   6.85741   1.000 16.15568 ? 227 LYS F HD2    1 
ATOM   2018 H  HD3    . LYS C 3 63 ? -1.21874  5.15280   8.34113   1.000 16.15568 ? 227 LYS F HD3    1 
ATOM   2019 H  HE2    . LYS C 3 63 ? 0.13590   7.02800   8.66513   1.000 17.03130 ? 227 LYS F HE2    1 
ATOM   2020 H  HE3    . LYS C 3 63 ? 0.61031   6.92353   7.15204   1.000 17.03130 ? 227 LYS F HE3    1 
ATOM   2021 H  HZ1    . LYS C 3 63 ? -1.95923  7.52206   7.89601   1.000 17.27661 ? 227 LYS F HZ1    1 
ATOM   2022 H  HZ2    . LYS C 3 63 ? -1.02313  8.49666   7.37429   1.000 17.27661 ? 227 LYS F HZ2    1 
ATOM   2023 H  HZ3    . LYS C 3 63 ? -1.51879  7.43816   6.51858   1.000 17.27661 ? 227 LYS F HZ3    1 
ATOM   2024 N  N      . MET C 3 64 ? 4.89620   4.02579   6.31962   1.000 9.56712  ? 228 MET F N      1 
ATOM   2025 C  CA     . MET C 3 64 ? 5.81886   3.84063   5.20811   1.000 10.45560 ? 228 MET F CA     1 
ATOM   2026 C  C      . MET C 3 64 ? 6.56967   2.52381   5.35929   1.000 9.46920  ? 228 MET F C      1 
ATOM   2027 O  O      . MET C 3 64 ? 6.71246   1.77444   4.39200   1.000 9.85596  ? 228 MET F O      1 
ATOM   2028 C  CB     . MET C 3 64 ? 6.79061   5.01896   5.11228   1.000 12.94880 ? 228 MET F CB     1 
ATOM   2029 C  CG     . MET C 3 64 ? 7.59866   4.98717   3.83586   1.000 16.38263 ? 228 MET F CG     1 
ATOM   2030 S  SD     . MET C 3 64 ? 8.78640   6.35026   3.69300   1.000 13.50798 ? 228 MET F SD     1 
ATOM   2031 C  CE     . MET C 3 64 ? 9.98057   5.73280   4.84434   1.000 17.32796 ? 228 MET F CE     1 
ATOM   2032 H  H      . MET C 3 64 ? 5.07696   4.69076   6.83415   1.000 11.48054 ? 228 MET F H      1 
ATOM   2033 H  HA     . MET C 3 64 ? 5.31477   3.82744   4.37949   1.000 12.54672 ? 228 MET F HA     1 
ATOM   2034 H  HB2    . MET C 3 64 ? 6.28796   5.84833   5.13229   1.000 15.53856 ? 228 MET F HB2    1 
ATOM   2035 H  HB3    . MET C 3 64 ? 7.40584   4.98574   5.86146   1.000 15.53856 ? 228 MET F HB3    1 
ATOM   2036 H  HG2    . MET C 3 64 ? 8.09671   4.15549   3.80172   1.000 19.65915 ? 228 MET F HG2    1 
ATOM   2037 H  HG3    . MET C 3 64 ? 6.99248   5.04209   3.08059   1.000 19.65915 ? 228 MET F HG3    1 
ATOM   2038 H  HE1    . MET C 3 64 ? 10.76341  6.30523   4.82486   1.000 20.79356 ? 228 MET F HE1    1 
ATOM   2039 H  HE2    . MET C 3 64 ? 9.59216   5.73372   5.73318   1.000 20.79356 ? 228 MET F HE2    1 
ATOM   2040 H  HE3    . MET C 3 64 ? 10.22532  4.82896   4.59124   1.000 20.79356 ? 228 MET F HE3    1 
ATOM   2041 N  N      . ALA C 3 65 ? 6.99094   2.19782   6.58038   1.000 10.24181 ? 229 ALA F N      1 
ATOM   2042 C  CA     . ALA C 3 65 ? 7.66677   0.93222   6.83217   1.000 11.62025 ? 229 ALA F CA     1 
ATOM   2043 C  C      . ALA C 3 65 ? 6.71613   -0.24357  6.68432   1.000 10.81246 ? 229 ALA F C      1 
ATOM   2044 O  O      . ALA C 3 65 ? 7.14023   -1.33185  6.28756   1.000 10.86647 ? 229 ALA F O      1 
ATOM   2045 C  CB     . ALA C 3 65 ? 8.30706   0.94375   8.23496   1.000 14.27157 ? 229 ALA F CB     1 
ATOM   2046 H  H      . ALA C 3 65 ? 6.89729   2.69187   7.27805   1.000 12.29017 ? 229 ALA F H      1 
ATOM   2047 H  HA     . ALA C 3 65 ? 8.38030   0.82053   6.18463   1.000 13.94431 ? 229 ALA F HA     1 
ATOM   2048 H  HB1    . ALA C 3 65 ? 8.78502   0.11068   8.37080   1.000 17.12589 ? 229 ALA F HB1    1 
ATOM   2049 H  HB2    . ALA C 3 65 ? 8.92194   1.69153   8.29531   1.000 17.12589 ? 229 ALA F HB2    1 
ATOM   2050 H  HB3    . ALA C 3 65 ? 7.60758   1.03612   8.90062   1.000 17.12589 ? 229 ALA F HB3    1 
ATOM   2051 N  N      . ARG C 3 66 ? 5.42112   -0.04836  6.97093   1.000 11.47098 ? 230 ARG F N      1 
ATOM   2052 C  CA     . ARG C 3 66 ? 4.45692   -1.11360  6.73661   1.000 13.27558 ? 230 ARG F CA     1 
ATOM   2053 C  C      . ARG C 3 66 ? 4.41232   -1.46592  5.25230   1.000 11.02865 ? 230 ARG F C      1 
ATOM   2054 O  O      . ARG C 3 66 ? 4.35286   -2.64273  4.88118   1.000 10.59877 ? 230 ARG F O      1 
ATOM   2055 C  CB     . ARG C 3 66 ? 3.07778   -0.69031  7.24968   1.000 11.32446 ? 230 ARG F CB     1 
ATOM   2056 C  CG     . ARG C 3 66 ? 1.96296   -1.72126  6.98823   1.000 10.48696 ? 230 ARG F CG     1 
ATOM   2057 C  CD     . ARG C 3 66 ? 2.18583   -2.95574  7.83626   1.000 11.62918 ? 230 ARG F CD     1 
ATOM   2058 N  NE     . ARG C 3 66 ? 1.24906   -4.01964  7.48599   1.000 10.90503 ? 230 ARG F NE     1 
ATOM   2059 C  CZ     . ARG C 3 66 ? 1.46672   -4.89936  6.52191   1.000 11.32152 ? 230 ARG F CZ     1 
ATOM   2060 N  NH1    . ARG C 3 66 ? 2.52581   -4.81792  5.73642   1.000 13.79639 ? 230 ARG F NH1    1 
ATOM   2061 N  NH2    . ARG C 3 66 ? 0.62483   -5.91000  6.35761   1.000 16.47092 ? 230 ARG F NH2    1 
ATOM   2062 H  H      . ARG C 3 66 ? 5.08925   0.67631   7.29389   1.000 13.76517 ? 230 ARG F H      1 
ATOM   2063 H  HA     . ARG C 3 66 ? 4.71633   -1.90797  7.22914   1.000 15.93069 ? 230 ARG F HA     1 
ATOM   2064 H  HB2    . ARG C 3 66 ? 3.13239   -0.55269  8.20832   1.000 13.58935 ? 230 ARG F HB2    1 
ATOM   2065 H  HB3    . ARG C 3 66 ? 2.82349   0.13599   6.80985   1.000 13.58935 ? 230 ARG F HB3    1 
ATOM   2066 H  HG2    . ARG C 3 66 ? 1.10251   -1.33728  7.21866   1.000 12.58435 ? 230 ARG F HG2    1 
ATOM   2067 H  HG3    . ARG C 3 66 ? 1.97085   -1.98082  6.05364   1.000 12.58435 ? 230 ARG F HG3    1 
ATOM   2068 H  HD2    . ARG C 3 66 ? 3.08757   -3.28412  7.69509   1.000 13.95502 ? 230 ARG F HD2    1 
ATOM   2069 H  HD3    . ARG C 3 66 ? 2.05712   -2.73103  8.77105   1.000 13.95502 ? 230 ARG F HD3    1 
ATOM   2070 H  HE     . ARG C 3 66 ? 0.51535   -4.07767  7.93087   1.000 13.08603 ? 230 ARG F HE     1 
ATOM   2071 H  HH11   . ARG C 3 66 ? 3.09411   -4.18172  5.84542   1.000 16.55567 ? 230 ARG F HH11   1 
ATOM   2072 H  HH12   . ARG C 3 66 ? 2.64694   -5.40111  5.11608   1.000 16.55567 ? 230 ARG F HH12   1 
ATOM   2073 H  HH21   . ARG C 3 66 ? -0.05691  -5.99032  6.87566   1.000 19.76510 ? 230 ARG F HH21   1 
ATOM   2074 H  HH22   . ARG C 3 66 ? 0.76037   -6.48537  5.73296   1.000 19.76510 ? 230 ARG F HH22   1 
ATOM   2075 N  N      . ALA C 3 67 ? 4.45429   -0.45592  4.38770   1.000 9.68895  ? 231 ALA F N      1 
ATOM   2076 C  CA     . ALA C 3 67 ? 4.56097   -0.72696  2.95590   1.000 8.92558  ? 231 ALA F CA     1 
ATOM   2077 C  C      . ALA C 3 67 ? 5.89808   -1.37798  2.62145   1.000 10.65516 ? 231 ALA F C      1 
ATOM   2078 O  O      . ALA C 3 67 ? 5.95508   -2.31751  1.83213   1.000 11.31334 ? 231 ALA F O      1 
ATOM   2079 C  CB     . ALA C 3 67 ? 4.38252   0.55664   2.16398   1.000 11.04376 ? 231 ALA F CB     1 
ATOM   2080 H  H      . ALA C 3 67 ? 4.42346   0.37746   4.59776   1.000 11.62674 ? 231 ALA F H      1 
ATOM   2081 H  HA     . ALA C 3 67 ? 3.85169   -1.33687  2.69931   1.000 10.71069 ? 231 ALA F HA     1 
ATOM   2082 H  HB1    . ALA C 3 67 ? 4.47955   0.36074   1.21893   1.000 13.25251 ? 231 ALA F HB1    1 
ATOM   2083 H  HB2    . ALA C 3 67 ? 3.49817   0.91497   2.33841   1.000 13.25251 ? 231 ALA F HB2    1 
ATOM   2084 H  HB3    . ALA C 3 67 ? 5.05852   1.19493   2.44058   1.000 13.25251 ? 231 ALA F HB3    1 
ATOM   2085 N  N      . LEU C 3 68 ? 6.98737   -0.89253  3.21190   1.000 10.09398 ? 232 LEU F N      1 
ATOM   2086 C  CA     . LEU C 3 68 ? 8.29782   -1.46965  2.90489   1.000 8.98684  ? 232 LEU F CA     1 
ATOM   2087 C  C      . LEU C 3 68 ? 8.34051   -2.96220  3.18543   1.000 11.24761 ? 232 LEU F C      1 
ATOM   2088 O  O      . LEU C 3 68 ? 8.96183   -3.72000  2.43558   1.000 12.25922 ? 232 LEU F O      1 
ATOM   2089 C  CB     . LEU C 3 68 ? 9.39149   -0.77901  3.71315   1.000 13.09927 ? 232 LEU F CB     1 
ATOM   2090 C  CG     . LEU C 3 68 ? 9.82114   0.58327   3.20580   1.000 12.51816 ? 232 LEU F CG     1 
ATOM   2091 C  CD1    . LEU C 3 68 ? 10.92469  1.08821   4.12027   1.000 16.99376 ? 232 LEU F CD1    1 
ATOM   2092 C  CD2    . LEU C 3 68 ? 10.28819  0.55114   1.75388   1.000 12.43525 ? 232 LEU F CD2    1 
ATOM   2093 H  H      . LEU C 3 68 ? 6.99792   -0.24652  3.77950   1.000 12.11278 ? 232 LEU F H      1 
ATOM   2094 H  HA     . LEU C 3 68 ? 8.46476   -1.32468  1.96042   1.000 10.78420 ? 232 LEU F HA     1 
ATOM   2095 H  HB2    . LEU C 3 68 ? 9.06989   -0.66088  4.62063   1.000 15.71913 ? 232 LEU F HB2    1 
ATOM   2096 H  HB3    . LEU C 3 68 ? 10.17656  -1.34871  3.71091   1.000 15.71913 ? 232 LEU F HB3    1 
ATOM   2097 H  HG     . LEU C 3 68 ? 9.06364   1.18903   3.21783   1.000 15.02179 ? 232 LEU F HG     1 
ATOM   2098 H  HD11   . LEU C 3 68 ? 11.22743  1.95310   3.80214   1.000 20.39251 ? 232 LEU F HD11   1 
ATOM   2099 H  HD12   . LEU C 3 68 ? 10.57503  1.17103   5.02126   1.000 20.39251 ? 232 LEU F HD12   1 
ATOM   2100 H  HD13   . LEU C 3 68 ? 11.65966  0.45530   4.10757   1.000 20.39251 ? 232 LEU F HD13   1 
ATOM   2101 H  HD21   . LEU C 3 68 ? 10.72013  1.39352   1.54237   1.000 14.92230 ? 232 LEU F HD21   1 
ATOM   2102 H  HD22   . LEU C 3 68 ? 10.91542  -0.17996  1.64001   1.000 14.92230 ? 232 LEU F HD22   1 
ATOM   2103 H  HD23   . LEU C 3 68 ? 9.51907   0.41992   1.17756   1.000 14.92230 ? 232 LEU F HD23   1 
ATOM   2104 N  N      . ARG C 3 69 ? 7.71824   -3.39956  4.27787   1.000 12.79810 ? 233 ARG F N      1 
ATOM   2105 C  CA     . ARG C 3 69 ? 7.77011   -4.81177  4.62947   1.000 16.44887 ? 233 ARG F CA     1 
ATOM   2106 C  C      . ARG C 3 69 ? 7.10430   -5.66429  3.56467   1.000 11.07875 ? 233 ARG F C      1 
ATOM   2107 O  O      . ARG C 3 69 ? 7.49049   -6.81644  3.36693   1.000 15.71855 ? 233 ARG F O      1 
ATOM   2108 C  CB     . ARG C 3 69 ? 7.13037   -5.04715  6.00250   1.000 17.74949 ? 233 ARG F CB     1 
ATOM   2109 C  CG     . ARG C 3 69 ? 8.03695   -4.56282  7.16821   1.000 19.29496 ? 233 ARG F CG     1 
ATOM   2110 C  CD     . ARG C 3 69 ? 7.60717   -5.13444  8.51665   1.000 20.25188 ? 233 ARG F CD     1 
ATOM   2111 N  NE     . ARG C 3 69 ? 6.32082   -4.60504  8.93131   1.000 19.01266 ? 233 ARG F NE     1 
ATOM   2112 C  CZ     . ARG C 3 69 ? 6.13635   -3.39523  9.44584   1.000 15.47106 ? 233 ARG F CZ     1 
ATOM   2113 N  NH1    . ARG C 3 69 ? 7.14793   -2.56188  9.65369   1.000 22.19300 ? 233 ARG F NH1    1 
ATOM   2114 N  NH2    . ARG C 3 69 ? 4.91513   -3.02840  9.79624   1.000 11.95745 ? 233 ARG F NH2    1 
ATOM   2115 H  H      . ARG C 3 69 ? 7.26811   -2.90781  4.82116   1.000 15.35772 ? 233 ARG F H      1 
ATOM   2116 H  HA     . ARG C 3 69 ? 8.69765   -5.08737  4.69744   1.000 19.73865 ? 233 ARG F HA     1 
ATOM   2117 H  HB2    . ARG C 3 69 ? 6.29237   -4.56089  6.04951   1.000 21.29939 ? 233 ARG F HB2    1 
ATOM   2118 H  HB3    . ARG C 3 69 ? 6.96996   -5.99667  6.11908   1.000 21.29939 ? 233 ARG F HB3    1 
ATOM   2119 H  HG2    . ARG C 3 69 ? 8.94960   -4.84455  6.99908   1.000 23.15396 ? 233 ARG F HG2    1 
ATOM   2120 H  HG3    . ARG C 3 69 ? 7.99329   -3.59540  7.22381   1.000 23.15396 ? 233 ARG F HG3    1 
ATOM   2121 H  HD2    . ARG C 3 69 ? 7.53251   -6.09910  8.44769   1.000 24.30225 ? 233 ARG F HD2    1 
ATOM   2122 H  HD3    . ARG C 3 69 ? 8.26521   -4.89988  9.18959   1.000 24.30225 ? 233 ARG F HD3    1 
ATOM   2123 H  HE     . ARG C 3 69 ? 5.63085   -5.10971  8.83722   1.000 22.81519 ? 233 ARG F HE     1 
ATOM   2124 H  HH11   . ARG C 3 69 ? 7.94962   -2.80043  9.45372   1.000 26.63160 ? 233 ARG F HH11   1 
ATOM   2125 H  HH12   . ARG C 3 69 ? 7.00181   -1.78327  9.98835   1.000 26.63160 ? 233 ARG F HH12   1 
ATOM   2126 H  HH21   . ARG C 3 69 ? 4.25605   -3.57044  9.68945   1.000 14.34894 ? 233 ARG F HH21   1 
ATOM   2127 H  HH22   . ARG C 3 69 ? 4.78001   -2.24780  10.13091  1.000 14.34894 ? 233 ARG F HH22   1 
ATOM   2128 N  N      . ASN C 3 70 ? 6.13111   -5.12054  2.85371   1.000 12.46822 ? 234 ASN F N      1 
ATOM   2129 C  CA     . ASN C 3 70 ? 5.49210   -5.90961  1.79967   1.000 14.91961 ? 234 ASN F CA     1 
ATOM   2130 C  C      . ASN C 3 70 ? 6.42525   -6.21821  0.63434   1.000 18.20443 ? 234 ASN F C      1 
ATOM   2131 O  O      . ASN C 3 70 ? 6.09530   -7.07109  -0.20363  1.000 16.45431 ? 234 ASN F O      1 
ATOM   2132 C  CB     . ASN C 3 70 ? 4.25151   -5.19261  1.28706   1.000 12.38681 ? 234 ASN F CB     1 
ATOM   2133 C  CG     . ASN C 3 70 ? 3.13350   -5.20656  2.29724   1.000 10.93434 ? 234 ASN F CG     1 
ATOM   2134 O  OD1    . ASN C 3 70 ? 3.10188   -6.06039  3.18767   1.000 15.83617 ? 234 ASN F OD1    1 
ATOM   2135 N  ND2    . ASN C 3 70 ? 2.24462   -4.22723  2.21418   1.000 14.78098 ? 234 ASN F ND2    1 
ATOM   2136 H  H      . ASN C 3 70 ? 5.82747   -4.32220  2.95400   1.000 14.96186 ? 234 ASN F H      1 
ATOM   2137 H  HA     . ASN C 3 70 ? 5.21165   -6.75574  2.18217   1.000 17.90353 ? 234 ASN F HA     1 
ATOM   2138 H  HB2    . ASN C 3 70 ? 4.47410   -4.26844  1.09400   1.000 14.86417 ? 234 ASN F HB2    1 
ATOM   2139 H  HB3    . ASN C 3 70 ? 3.93807   -5.63352  0.48191   1.000 14.86417 ? 234 ASN F HB3    1 
ATOM   2140 H  HD21   . ASN C 3 70 ? 2.32366   -3.62530  1.60505   1.000 17.73718 ? 234 ASN F HD21   1 
ATOM   2141 H  HD22   . ASN C 3 70 ? 1.58872   -4.19360  2.76940   1.000 17.73718 ? 234 ASN F HD22   1 
ATOM   2142 N  N      . TYR C 3 71 ? 7.55792   -5.52927  0.52503   1.000 13.22982 ? 235 TYR F N      1 
ATOM   2143 C  CA     . TYR C 3 71 ? 8.50557   -5.87780  -0.51534  1.000 15.87749 ? 235 TYR F CA     1 
ATOM   2144 C  C      . TYR C 3 71 ? 9.34377   -7.08703  -0.14563  1.000 16.38001 ? 235 TYR F C      1 
ATOM   2145 O  O      . TYR C 3 71 ? 10.09574  -7.57373  -0.99729  1.000 20.92451 ? 235 TYR F O      1 
ATOM   2146 C  CB     . TYR C 3 71 ? 9.47058   -4.71703  -0.80584  1.000 17.32319 ? 235 TYR F CB     1 
ATOM   2147 C  CG     . TYR C 3 71 ? 8.89756   -3.47905  -1.46597  1.000 13.00058 ? 235 TYR F CG     1 
ATOM   2148 C  CD1    . TYR C 3 71 ? 8.12729   -3.55366  -2.61732  1.000 16.57323 ? 235 TYR F CD1    1 
ATOM   2149 C  CD2    . TYR C 3 71 ? 9.18026   -2.22669  -0.95490  1.000 10.92680 ? 235 TYR F CD2    1 
ATOM   2150 C  CE1    . TYR C 3 71 ? 7.64595   -2.38420  -3.23883  1.000 15.06042 ? 235 TYR F CE1    1 
ATOM   2151 C  CE2    . TYR C 3 71 ? 8.70246   -1.06916  -1.53919  1.000 11.79044 ? 235 TYR F CE2    1 
ATOM   2152 C  CZ     . TYR C 3 71 ? 7.93298   -1.14606  -2.67893  1.000 13.31405 ? 235 TYR F CZ     1 
ATOM   2153 O  OH     . TYR C 3 71 ? 7.51995   0.03455   -3.23935  1.000 13.71685 ? 235 TYR F OH     1 
ATOM   2154 H  H      . TYR C 3 71 ? 7.79034   -4.87341  1.03043   1.000 15.87579 ? 235 TYR F H      1 
ATOM   2155 H  HA     . TYR C 3 71 ? 7.99896   -6.05817  -1.32263  1.000 19.05299 ? 235 TYR F HA     1 
ATOM   2156 H  HB2    . TYR C 3 71 ? 9.85501   -4.43187  0.03784   1.000 20.78782 ? 235 TYR F HB2    1 
ATOM   2157 H  HB3    . TYR C 3 71 ? 10.16774  -5.04980  -1.39246  1.000 20.78782 ? 235 TYR F HB3    1 
ATOM   2158 H  HD1    . TYR C 3 71 ? 7.92635   -4.38478  -2.98306  1.000 19.88787 ? 235 TYR F HD1    1 
ATOM   2159 H  HD2    . TYR C 3 71 ? 9.70932   -2.16071  -0.19290  1.000 13.11216 ? 235 TYR F HD2    1 
ATOM   2160 H  HE1    . TYR C 3 71 ? 7.14035   -2.44097  -4.01732  1.000 18.07250 ? 235 TYR F HE1    1 
ATOM   2161 H  HE2    . TYR C 3 71 ? 8.89973   -0.24128  -1.16422  1.000 14.14852 ? 235 TYR F HE2    1 
ATOM   2162 H  HH     . TYR C 3 71 ? 7.26207   -0.09650  -4.02797  1.000 16.46022 ? 235 TYR F HH     1 
ATOM   2163 N  N      . GLY C 3 72 ? 9.26833   -7.55203  1.09691   1.000 14.71514 ? 236 GLY F N      1 
ATOM   2164 C  CA     . GLY C 3 72 ? 10.17722  -8.60390  1.52240   1.000 23.98521 ? 236 GLY F CA     1 
ATOM   2165 C  C      . GLY C 3 72 ? 10.01065  -9.85759  0.68946   1.000 20.56828 ? 236 GLY F C      1 
ATOM   2166 O  O      . GLY C 3 72 ? 10.99328  -10.50391 0.31388   1.000 24.25204 ? 236 GLY F O      1 
ATOM   2167 H  H      . GLY C 3 72 ? 8.71429   -7.28219  1.69676   1.000 17.65817 ? 236 GLY F H      1 
ATOM   2168 H  HA2    . GLY C 3 72 ? 11.09274  -8.29522  1.43614   1.000 28.78226 ? 236 GLY F HA2    1 
ATOM   2169 H  HA3    . GLY C 3 72 ? 10.00463  -8.82490  2.45099   1.000 28.78226 ? 236 GLY F HA3    1 
ATOM   2170 N  N      . LYS C 3 73 ? 8.76490   -10.19173 0.35806   1.000 21.67506 ? 237 LYS F N      1 
ATOM   2171 C  CA     . LYS C 3 73 ? 8.49241   -11.41928 -0.37551  1.000 30.76501 ? 237 LYS F CA     1 
ATOM   2172 C  C      . LYS C 3 73 ? 8.96037   -11.30627 -1.82028  1.000 30.55486 ? 237 LYS F C      1 
ATOM   2173 O  O      . LYS C 3 73 ? 9.60423   -12.22341 -2.34610  1.000 37.92532 ? 237 LYS F O      1 
ATOM   2174 C  CB     . LYS C 3 73 ? 6.99631   -11.73070 -0.29766  1.000 37.04684 ? 237 LYS F CB     1 
ATOM   2175 C  CG     . LYS C 3 73 ? 6.64779   -13.17163 -0.60549  0.664 38.12448 ? 237 LYS F CG     1 
ATOM   2176 C  CD     . LYS C 3 73 ? 5.57432   -13.71697 0.33867   0.229 33.87708 ? 237 LYS F CD     1 
ATOM   2177 C  CE     . LYS C 3 73 ? 5.21532   -15.16249 -0.00776  0.780 37.69720 ? 237 LYS F CE     1 
ATOM   2178 N  NZ     . LYS C 3 73 ? 5.14149   -15.36428 -1.48780  0.656 34.62450 ? 237 LYS F NZ     1 
ATOM   2179 H  H      . LYS C 3 73 ? 8.06578   -9.72727  0.54543   1.000 26.01007 ? 237 LYS F H      1 
ATOM   2180 H  HA     . LYS C 3 73 ? 8.97396   -12.15790 0.02878   0.984 36.91802 ? 237 LYS F HA     1 
ATOM   2181 H  HB2    . LYS C 3 73 ? 6.68540   -11.53779 0.60069   1.000 44.45621 ? 237 LYS F HB2    1 
ATOM   2182 H  HB3    . LYS C 3 73 ? 6.52906   -11.17132 -0.93771  1.000 44.45621 ? 237 LYS F HB3    1 
ATOM   2183 H  HG2    . LYS C 3 73 ? 6.31122   -13.23177 -1.51324  1.000 45.74938 ? 237 LYS F HG2    1 
ATOM   2184 H  HG3    . LYS C 3 73 ? 7.44223   -13.71982 -0.50922  1.000 45.74938 ? 237 LYS F HG3    1 
ATOM   2185 H  HD2    . LYS C 3 73 ? 5.90484   -13.69376 1.25033   1.000 40.65250 ? 237 LYS F HD2    1 
ATOM   2186 H  HD3    . LYS C 3 73 ? 4.77288   -13.17588 0.26246   0.918 40.65250 ? 237 LYS F HD3    1 
ATOM   2187 H  HE2    . LYS C 3 73 ? 5.89401   -15.75693 0.34850   1.000 45.23664 ? 237 LYS F HE2    1 
ATOM   2188 H  HE3    . LYS C 3 73 ? 4.35049   -15.37971 0.37406   1.000 45.23664 ? 237 LYS F HE3    1 
ATOM   2189 H  HZ1    . LYS C 3 73 ? 5.95826   -15.33501 -1.84012  1.000 41.54940 ? 237 LYS F HZ1    1 
ATOM   2190 H  HZ2    . LYS C 3 73 ? 4.77682   -16.15558 -1.66931  0.933 41.54940 ? 237 LYS F HZ2    1 
ATOM   2191 H  HZ3    . LYS C 3 73 ? 4.64432   -14.72545 -1.85768  1.000 41.54940 ? 237 LYS F HZ3    1 
ATOM   2192 N  N      . THR C 3 74 ? 8.67773   -10.17800 -2.46758  1.000 20.79807 ? 238 THR F N      1 
ATOM   2193 C  CA     . THR C 3 74 ? 9.02671   -10.01129 -3.87094  1.000 18.33559 ? 238 THR F CA     1 
ATOM   2194 C  C      . THR C 3 74 ? 10.47537  -9.59161  -4.06812  1.000 24.67175 ? 238 THR F C      1 
ATOM   2195 O  O      . THR C 3 74 ? 11.02570  -9.79600  -5.15474  1.000 25.71997 ? 238 THR F O      1 
ATOM   2196 C  CB     . THR C 3 74 ? 8.08779   -8.99583  -4.51323  1.000 17.47724 ? 238 THR F CB     1 
ATOM   2197 O  OG1    . THR C 3 74 ? 7.94951   -7.87042  -3.64444  1.000 22.16844 ? 238 THR F OG1    1 
ATOM   2198 C  CG2    . THR C 3 74 ? 6.70872   -9.62819  -4.75631  1.000 30.83267 ? 238 THR F CG2    1 
ATOM   2199 H  H      . THR C 3 74 ? 8.28579   -9.49791  -2.11621  1.000 24.95769 ? 238 THR F H      1 
ATOM   2200 H  HA     . THR C 3 74 ? 8.90897   -10.85613 -4.33276  1.000 22.00271 ? 238 THR F HA     1 
ATOM   2201 H  HB     . THR C 3 74 ? 8.44594   -8.70522  -5.36656  1.000 20.97269 ? 238 THR F HB     1 
ATOM   2202 H  HG1    . THR C 3 74 ? 7.43335   -7.30383  -3.98817  1.000 26.60213 ? 238 THR F HG1    1 
ATOM   2203 H  HG21   . THR C 3 74 ? 6.11855   -8.98477  -5.17892  1.000 36.99921 ? 238 THR F HG21   1 
ATOM   2204 H  HG22   . THR C 3 74 ? 6.79593   -10.40235 -5.33420  1.000 36.99921 ? 238 THR F HG22   1 
ATOM   2205 H  HG23   . THR C 3 74 ? 6.31836   -9.90707  -3.91324  1.000 36.99921 ? 238 THR F HG23   1 
ATOM   2206 N  N      . GLY C 3 75 ? 11.10431  -9.00125  -3.05831  1.000 19.44437 ? 239 GLY F N      1 
ATOM   2207 C  CA     . GLY C 3 75 ? 12.54589  -8.84314  -3.04786  1.000 21.90446 ? 239 GLY F CA     1 
ATOM   2208 C  C      . GLY C 3 75 ? 13.08244  -7.44591  -3.30478  1.000 19.02758 ? 239 GLY F C      1 
ATOM   2209 O  O      . GLY C 3 75 ? 14.29475  -7.25188  -3.16130  1.000 18.14390 ? 239 GLY F O      1 
ATOM   2210 H  H      . GLY C 3 75 ? 10.71053  -8.68250  -2.36337  1.000 23.33324 ? 239 GLY F H      1 
ATOM   2211 H  HA2    . GLY C 3 75 ? 12.87519  -9.12220  -2.17919  1.000 26.28536 ? 239 GLY F HA2    1 
ATOM   2212 H  HA3    . GLY C 3 75 ? 12.91955  -9.42417  -3.72881  1.000 26.28536 ? 239 GLY F HA3    1 
ATOM   2213 N  N      . GLU C 3 76 ? 12.24082  -6.46530  -3.67238  1.000 13.89984 ? 240 GLU F N      1 
ATOM   2214 C  CA     . GLU C 3 76 ? 12.76443  -5.15338  -4.06963  1.000 16.42129 ? 240 GLU F CA     1 
ATOM   2215 C  C      . GLU C 3 76 ? 13.53804  -4.49756  -2.94227  1.000 13.85085 ? 240 GLU F C      1 
ATOM   2216 O  O      . GLU C 3 76 ? 14.52296  -3.78772  -3.18246  1.000 13.73793 ? 240 GLU F O      1 
ATOM   2217 C  CB     . GLU C 3 76 ? 11.63924  -4.20583  -4.48512  1.000 18.35750 ? 240 GLU F CB     1 
ATOM   2218 C  CG     . GLU C 3 76 ? 10.95787  -4.56229  -5.78489  1.000 16.12208 ? 240 GLU F CG     1 
ATOM   2219 C  CD     . GLU C 3 76 ? 9.81600   -5.55523  -5.59886  1.000 22.35545 ? 240 GLU F CD     1 
ATOM   2220 O  OE1    . GLU C 3 76 ? 9.63574   -6.09198  -4.47636  1.000 17.56981 ? 240 GLU F OE1    1 
ATOM   2221 O  OE2    . GLU C 3 76 ? 9.10909   -5.80205  -6.60083  1.000 22.44537 ? 240 GLU F OE2    1 
ATOM   2222 H  H      . GLU C 3 76 ? 11.38400  -6.53418  -3.69906  1.000 16.67981 ? 240 GLU F H      1 
ATOM   2223 H  HA     . GLU C 3 76 ? 13.34806  -5.30321  -4.82979  1.000 19.70555 ? 240 GLU F HA     1 
ATOM   2224 H  HB2    . GLU C 3 76 ? 10.96217  -4.20892  -3.79052  1.000 22.02901 ? 240 GLU F HB2    1 
ATOM   2225 H  HB3    . GLU C 3 76 ? 12.00861  -3.31442  -4.58440  1.000 22.02901 ? 240 GLU F HB3    1 
ATOM   2226 H  HG2    . GLU C 3 76 ? 10.59269  -3.75610  -6.18188  1.000 19.34650 ? 240 GLU F HG2    1 
ATOM   2227 H  HG3    . GLU C 3 76 ? 11.60819  -4.96170  -6.38360  1.000 19.34650 ? 240 GLU F HG3    1 
ATOM   2228 N  N      . VAL C 3 77 ? 13.05039  -4.65968  -1.71840  1.000 13.85353 ? 241 VAL F N      1 
ATOM   2229 C  CA     . VAL C 3 77 ? 13.62888  -4.07488  -0.51664  1.000 13.82583 ? 241 VAL F CA     1 
ATOM   2230 C  C      . VAL C 3 77 ? 13.48555  -5.11441  0.58260   1.000 14.69525 ? 241 VAL F C      1 
ATOM   2231 O  O      . VAL C 3 77 ? 12.39802  -5.67124  0.77532   1.000 15.41224 ? 241 VAL F O      1 
ATOM   2232 C  CB     . VAL C 3 77 ? 12.94079  -2.76140  -0.08976  1.000 11.23338 ? 241 VAL F CB     1 
ATOM   2233 C  CG1    . VAL C 3 77 ? 13.65796  -2.17260  1.11039   1.000 15.06486 ? 241 VAL F CG1    1 
ATOM   2234 C  CG2    . VAL C 3 77 ? 12.89191  -1.76343  -1.24319  1.000 14.10401 ? 241 VAL F CG2    1 
ATOM   2235 H  H      . VAL C 3 77 ? 12.34911  -5.12829  -1.55045  1.000 16.62424 ? 241 VAL F H      1 
ATOM   2236 H  HA     . VAL C 3 77 ? 14.56439  -3.87231  -0.67378  1.000 16.59100 ? 241 VAL F HA     1 
ATOM   2237 H  HB     . VAL C 3 77 ? 12.02341  -2.95221  0.16108   1.000 13.48005 ? 241 VAL F HB     1 
ATOM   2238 H  HG11   . VAL C 3 77 ? 13.29496  -1.29213  1.29452   1.000 18.07783 ? 241 VAL F HG11   1 
ATOM   2239 H  HG12   . VAL C 3 77 ? 13.52206  -2.75307  1.87556   1.000 18.07783 ? 241 VAL F HG12   1 
ATOM   2240 H  HG13   . VAL C 3 77 ? 14.60474  -2.10490  0.91059   1.000 18.07783 ? 241 VAL F HG13   1 
ATOM   2241 H  HG21   . VAL C 3 77 ? 12.51215  -0.92997  -0.92379  1.000 16.92481 ? 241 VAL F HG21   1 
ATOM   2242 H  HG22   . VAL C 3 77 ? 13.79309  -1.61293  -1.56897  1.000 16.92481 ? 241 VAL F HG22   1 
ATOM   2243 H  HG23   . VAL C 3 77 ? 12.34016  -2.12782  -1.95291  1.000 16.92481 ? 241 VAL F HG23   1 
ATOM   2244 N  N      . LYS C 3 78 ? 14.57341  -5.38557  1.29113   1.000 13.52763 ? 242 LYS F N      1 
ATOM   2245 C  CA     . LYS C 3 78 ? 14.57443  -6.30333  2.42018   1.000 13.91780 ? 242 LYS F CA     1 
ATOM   2246 C  C      . LYS C 3 78 ? 15.08103  -5.61237  3.67610   1.000 16.46131 ? 242 LYS F C      1 
ATOM   2247 O  O      . LYS C 3 78 ? 15.97811  -4.76403  3.61387   1.000 16.80487 ? 242 LYS F O      1 
ATOM   2248 C  CB     . LYS C 3 78 ? 15.43813  -7.51606  2.13109   1.000 18.98046 ? 242 LYS F CB     1 
ATOM   2249 C  CG     . LYS C 3 78 ? 14.84403  -8.41074  1.04837   1.000 24.69996 ? 242 LYS F CG     1 
ATOM   2250 C  CD     . LYS C 3 78 ? 15.73941  -9.61725  0.75296   1.000 36.25905 ? 242 LYS F CD     1 
ATOM   2251 C  CE     . LYS C 3 78 ? 15.00302  -10.65816 -0.08650  1.000 32.46688 ? 242 LYS F CE     1 
ATOM   2252 N  NZ     . LYS C 3 78 ? 13.94202  -11.36185 0.69677   1.000 56.93770 ? 242 LYS F NZ     1 
ATOM   2253 H  H      . LYS C 3 78 ? 15.34461  -5.03988  1.13188   1.000 16.23316 ? 242 LYS F H      1 
ATOM   2254 H  HA     . LYS C 3 78 ? 13.66395  -6.59309  2.58742   1.000 16.70136 ? 242 LYS F HA     1 
ATOM   2255 H  HB2    . LYS C 3 78 ? 16.31127  -7.21869  1.83094   1.000 22.77655 ? 242 LYS F HB2    1 
ATOM   2256 H  HB3    . LYS C 3 78 ? 15.52717  -8.04183  2.94136   1.000 22.77655 ? 242 LYS F HB3    1 
ATOM   2257 H  HG2    . LYS C 3 78 ? 13.97993  -8.73879  1.34266   1.000 29.63996 ? 242 LYS F HG2    1 
ATOM   2258 H  HG3    . LYS C 3 78 ? 14.74370  -7.89958  0.23011   1.000 29.63996 ? 242 LYS F HG3    1 
ATOM   2259 H  HD2    . LYS C 3 78 ? 16.52237  -9.32497  0.26056   1.000 43.51086 ? 242 LYS F HD2    1 
ATOM   2260 H  HD3    . LYS C 3 78 ? 16.00812  -10.03158 1.58784   1.000 43.51086 ? 242 LYS F HD3    1 
ATOM   2261 H  HE2    . LYS C 3 78 ? 14.58095  -10.21879 -0.84129  1.000 38.96026 ? 242 LYS F HE2    1 
ATOM   2262 H  HE3    . LYS C 3 78 ? 15.63731  -11.32130 -0.40086  1.000 38.96026 ? 242 LYS F HE3    1 
ATOM   2263 H  HZ1    . LYS C 3 78 ? 14.30759  -11.79796 1.38107   1.000 68.32524 ? 242 LYS F HZ1    1 
ATOM   2264 H  HZ2    . LYS C 3 78 ? 13.35407  -10.77221 1.01100   1.000 68.32524 ? 242 LYS F HZ2    1 
ATOM   2265 H  HZ3    . LYS C 3 78 ? 13.51622  -11.94527 0.17676   1.000 68.32524 ? 242 LYS F HZ3    1 
ATOM   2266 N  N      . LYS C 3 79 ? 14.50740  -5.97729  4.82189   1.000 12.42367 ? 243 LYS F N      1 
ATOM   2267 C  CA     . LYS C 3 79 ? 14.96758  -5.41565  6.08107   1.000 13.13270 ? 243 LYS F CA     1 
ATOM   2268 C  C      . LYS C 3 79 ? 16.31024  -6.03886  6.43844   1.000 16.85034 ? 243 LYS F C      1 
ATOM   2269 O  O      . LYS C 3 79 ? 16.48278  -7.25199  6.32035   1.000 18.46610 ? 243 LYS F O      1 
ATOM   2270 C  CB     . LYS C 3 79 ? 13.95786  -5.68690  7.18832   1.000 16.87788 ? 243 LYS F CB     1 
ATOM   2271 C  CG     . LYS C 3 79 ? 14.33789  -5.05204  8.52818   1.000 13.26781 ? 243 LYS F CG     1 
ATOM   2272 C  CD     . LYS C 3 79 ? 14.10201  -3.55780  8.51013   1.000 14.97895 ? 243 LYS F CD     1 
ATOM   2273 C  CE     . LYS C 3 79 ? 14.45078  -2.91951  9.84412   1.000 17.80315 ? 243 LYS F CE     1 
ATOM   2274 N  NZ     . LYS C 3 79 ? 15.90598  -3.02289  10.19495  1.000 21.28076 ? 243 LYS F NZ     1 
ATOM   2275 H  H      . LYS C 3 79 ? 13.86054  -6.53963  4.89218   1.000 14.90841 ? 243 LYS F H      1 
ATOM   2276 H  HA     . LYS C 3 79 ? 15.06648  -4.45430  5.99788   1.000 15.75924 ? 243 LYS F HA     1 
ATOM   2277 H  HB2    . LYS C 3 79 ? 13.09729  -5.32709  6.92214   1.000 20.25346 ? 243 LYS F HB2    1 
ATOM   2278 H  HB3    . LYS C 3 79 ? 13.88980  -6.64524  7.32193   1.000 20.25346 ? 243 LYS F HB3    1 
ATOM   2279 H  HG2    . LYS C 3 79 ? 13.79651  -5.43919  9.23381   1.000 15.92138 ? 243 LYS F HG2    1 
ATOM   2280 H  HG3    . LYS C 3 79 ? 15.27803  -5.21170  8.70582   1.000 15.92138 ? 243 LYS F HG3    1 
ATOM   2281 H  HD2    . LYS C 3 79 ? 14.65717  -3.15364  7.82503   1.000 17.97473 ? 243 LYS F HD2    1 
ATOM   2282 H  HD3    . LYS C 3 79 ? 13.16611  -3.38298  8.32459   1.000 17.97473 ? 243 LYS F HD3    1 
ATOM   2283 H  HE2    . LYS C 3 79 ? 14.21995  -1.97796  9.81092   1.000 21.36378 ? 243 LYS F HE2    1 
ATOM   2284 H  HE3    . LYS C 3 79 ? 13.94489  -3.36063  10.54440  1.000 21.36378 ? 243 LYS F HE3    1 
ATOM   2285 H  HZ1    . LYS C 3 79 ? 16.14565  -3.87819  10.25068  1.000 25.53692 ? 243 LYS F HZ1    1 
ATOM   2286 H  HZ2    . LYS C 3 79 ? 16.39884  -2.62496  9.56977   1.000 25.53692 ? 243 LYS F HZ2    1 
ATOM   2287 H  HZ3    . LYS C 3 79 ? 16.05910  -2.62841  10.97793  1.000 25.53692 ? 243 LYS F HZ3    1 
ATOM   2288 N  N      . VAL C 3 80 ? 17.26471  -5.19553  6.83741   1.000 16.42660 ? 244 VAL F N      1 
ATOM   2289 C  CA     . VAL C 3 80 ? 18.55233  -5.62047  7.38448   1.000 18.45976 ? 244 VAL F CA     1 
ATOM   2290 C  C      . VAL C 3 80 ? 18.46205  -5.60739  8.90344   1.000 18.35678 ? 244 VAL F C      1 
ATOM   2291 O  O      . VAL C 3 80 ? 17.77105  -4.76969  9.48728   1.000 17.67515 ? 244 VAL F O      1 
ATOM   2292 C  CB     . VAL C 3 80 ? 19.68433  -4.69195  6.89876   1.000 14.70942 ? 244 VAL F CB     1 
ATOM   2293 C  CG1    . VAL C 3 80 ? 21.00185  -5.00850  7.62673   1.000 21.20649 ? 244 VAL F CG1    1 
ATOM   2294 C  CG2    . VAL C 3 80 ? 19.82700  -4.79950  5.39587   1.000 18.00697 ? 244 VAL F CG2    1 
ATOM   2295 H  H      . VAL C 3 80 ? 17.18562  -4.34003  6.79911   1.000 19.71192 ? 244 VAL F H      1 
ATOM   2296 H  HA     . VAL C 3 80 ? 18.74414  -6.52599  7.09439   1.000 22.15171 ? 244 VAL F HA     1 
ATOM   2297 H  HB     . VAL C 3 80 ? 19.46335  -3.77141  7.11011   1.000 17.65130 ? 244 VAL F HB     1 
ATOM   2298 H  HG11   . VAL C 3 80 ? 21.72990  -4.55543  7.17335   1.000 25.44779 ? 244 VAL F HG11   1 
ATOM   2299 H  HG12   . VAL C 3 80 ? 20.93867  -4.69781  8.54345   1.000 25.44779 ? 244 VAL F HG12   1 
ATOM   2300 H  HG13   . VAL C 3 80 ? 21.14846  -5.96724  7.61177   1.000 25.44779 ? 244 VAL F HG13   1 
ATOM   2301 H  HG21   . VAL C 3 80 ? 20.56140  -4.23539  5.10719   1.000 21.60836 ? 244 VAL F HG21   1 
ATOM   2302 H  HG22   . VAL C 3 80 ? 20.00734  -5.72322  5.16107   1.000 21.60836 ? 244 VAL F HG22   1 
ATOM   2303 H  HG23   . VAL C 3 80 ? 19.00157  -4.50723  4.97857   1.000 21.60836 ? 244 VAL F HG23   1 
ATOM   2304 N  N      . LYS C 3 81 ? 19.17624  -6.53513  9.55528   1.000 19.38665 ? 245 LYS F N      1 
ATOM   2305 C  CA     . LYS C 3 81 ? 19.14252  -6.66625  11.01381  1.000 24.22358 ? 245 LYS F CA     1 
ATOM   2306 C  C      . LYS C 3 81 ? 20.06960  -5.63624  11.65778  1.000 25.40995 ? 245 LYS F C      1 
ATOM   2307 O  O      . LYS C 3 81 ? 20.99562  -5.94706  12.40927  1.000 29.28408 ? 245 LYS F O      1 
ATOM   2308 C  CB     . LYS C 3 81 ? 19.52527  -8.07813  11.44026  1.000 34.55280 ? 245 LYS F CB     1 
ATOM   2309 C  CG     . LYS C 3 81 ? 18.55857  -9.14546  10.98202  1.000 36.99835 ? 245 LYS F CG     1 
ATOM   2310 C  CD     . LYS C 3 81 ? 17.27749  -9.10603  11.78739  1.000 36.00106 ? 245 LYS F CD     1 
ATOM   2311 C  CE     . LYS C 3 81 ? 16.50525  -10.41483 11.64812  1.000 39.92696 ? 245 LYS F CE     1 
ATOM   2312 N  NZ     . LYS C 3 81 ? 15.24214  -10.39414 12.44959  1.000 48.27501 ? 245 LYS F NZ     1 
ATOM   2313 H  H      . LYS C 3 81 ? 19.69206  -7.10450  9.16882   1.000 23.26398 ? 245 LYS F H      1 
ATOM   2314 H  HA     . LYS C 3 81 ? 18.23443  -6.49979  11.31144  1.000 29.06829 ? 245 LYS F HA     1 
ATOM   2315 H  HB2    . LYS C 3 81 ? 20.39563  -8.28955  11.06789  1.000 41.46336 ? 245 LYS F HB2    1 
ATOM   2316 H  HB3    . LYS C 3 81 ? 19.56215  -8.11043  12.40902  1.000 41.46336 ? 245 LYS F HB3    1 
ATOM   2317 H  HG2    . LYS C 3 81 ? 18.33785  -9.00130  10.04853  1.000 44.39802 ? 245 LYS F HG2    1 
ATOM   2318 H  HG3    . LYS C 3 81 ? 18.96491  -10.01886 11.09581  1.000 44.39802 ? 245 LYS F HG3    1 
ATOM   2319 H  HD2    . LYS C 3 81 ? 17.48864  -8.97216  12.72461  1.000 43.20127 ? 245 LYS F HD2    1 
ATOM   2320 H  HD3    . LYS C 3 81 ? 16.71625  -8.38261  11.46713  1.000 43.20127 ? 245 LYS F HD3    1 
ATOM   2321 H  HE2    . LYS C 3 81 ? 16.27314  -10.55316 10.71651  1.000 47.91235 ? 245 LYS F HE2    1 
ATOM   2322 H  HE3    . LYS C 3 81 ? 17.05576  -11.14782 11.96523  1.000 47.91235 ? 245 LYS F HE3    1 
ATOM   2323 H  HZ1    . LYS C 3 81 ? 15.43000  -10.27003 13.31064  1.000 57.93002 ? 245 LYS F HZ1    1 
ATOM   2324 H  HZ2    . LYS C 3 81 ? 14.71545  -9.73315  12.17069  1.000 57.93002 ? 245 LYS F HZ2    1 
ATOM   2325 H  HZ3    . LYS C 3 81 ? 14.80999  -11.16661 12.35667  1.000 57.93002 ? 245 LYS F HZ3    1 
ATOM   2326 N  N      . LYS C 3 82 ? 19.79953  -4.38515  11.32118  1.000 19.83397 ? 246 LYS F N      1 
ATOM   2327 C  CA     . LYS C 3 82 ? 20.46238  -3.22375  11.88105  1.000 21.59497 ? 246 LYS F CA     1 
ATOM   2328 C  C      . LYS C 3 82 ? 19.41279  -2.13385  11.97612  1.000 22.17097 ? 246 LYS F C      1 
ATOM   2329 O  O      . LYS C 3 82 ? 18.46637  -2.09275  11.17856  1.000 18.01674 ? 246 LYS F O      1 
ATOM   2330 C  CB     . LYS C 3 82 ? 21.63732  -2.74785  11.02380  1.000 21.22354 ? 246 LYS F CB     1 
ATOM   2331 C  CG     . LYS C 3 82 ? 22.74756  -3.77079  10.86675  1.000 37.32227 ? 246 LYS F CG     1 
ATOM   2332 C  CD     . LYS C 3 82 ? 23.62970  -3.84969  12.10715  1.000 36.98687 ? 246 LYS F CD     1 
ATOM   2333 C  CE     . LYS C 3 82 ? 24.68444  -4.92602  11.96025  1.000 46.00383 ? 246 LYS F CE     1 
ATOM   2334 N  NZ     . LYS C 3 82 ? 25.91644  -4.61047  12.73000  1.000 49.76316 ? 246 LYS F NZ     1 
ATOM   2335 H  H      . LYS C 3 82 ? 19.20348  -4.17296  10.73869  1.000 23.80077 ? 246 LYS F H      1 
ATOM   2336 H  HA     . LYS C 3 82 ? 20.82351  -3.42375  12.75882  1.000 25.91397 ? 246 LYS F HA     1 
ATOM   2337 H  HB2    . LYS C 3 82 ? 21.30739  -2.53324  10.13724  1.000 25.46825 ? 246 LYS F HB2    1 
ATOM   2338 H  HB3    . LYS C 3 82 ? 22.02126  -1.95773  11.43516  1.000 25.46825 ? 246 LYS F HB3    1 
ATOM   2339 H  HG2    . LYS C 3 82 ? 22.35689  -4.64588  10.71675  1.000 44.78672 ? 246 LYS F HG2    1 
ATOM   2340 H  HG3    . LYS C 3 82 ? 23.30594  -3.52317  10.11323  1.000 44.78672 ? 246 LYS F HG3    1 
ATOM   2341 H  HD2    . LYS C 3 82 ? 24.07657  -2.99904  12.23983  1.000 44.38425 ? 246 LYS F HD2    1 
ATOM   2342 H  HD3    . LYS C 3 82 ? 23.08215  -4.06082  12.87949  1.000 44.38425 ? 246 LYS F HD3    1 
ATOM   2343 H  HE2    . LYS C 3 82 ? 24.32968  -5.76700  12.28857  1.000 55.20459 ? 246 LYS F HE2    1 
ATOM   2344 H  HE3    . LYS C 3 82 ? 24.92568  -5.01043  11.02452  1.000 55.20459 ? 246 LYS F HE3    1 
ATOM   2345 H  HZ1    . LYS C 3 82 ? 26.50172  -5.27666  12.65422  1.000 59.71580 ? 246 LYS F HZ1    1 
ATOM   2346 H  HZ2    . LYS C 3 82 ? 26.28702  -3.86361  12.41859  1.000 59.71580 ? 246 LYS F HZ2    1 
ATOM   2347 H  HZ3    . LYS C 3 82 ? 25.71740  -4.49729  13.59004  1.000 59.71580 ? 246 LYS F HZ3    1 
ATOM   2348 N  N      . LYS C 3 83 ? 19.57174  -1.25449  12.95688  1.000 19.89538 ? 247 LYS F N      1 
ATOM   2349 C  CA     . LYS C 3 83 ? 18.51626  -0.28905  13.23258  1.000 18.53099 ? 247 LYS F CA     1 
ATOM   2350 C  C      . LYS C 3 83 ? 18.19581  0.54808   11.99494  1.000 14.55866 ? 247 LYS F C      1 
ATOM   2351 O  O      . LYS C 3 83 ? 19.08644  1.15401   11.39683  1.000 16.00085 ? 247 LYS F O      1 
ATOM   2352 C  CB     . LYS C 3 83 ? 18.93650  0.61846   14.38382  0.871 20.43574 ? 247 LYS F CB     1 
ATOM   2353 C  CG     . LYS C 3 83 ? 17.79430  1.37425   15.04212  0.372 24.41371 ? 247 LYS F CG     1 
ATOM   2354 C  CD     . LYS C 3 83 ? 18.18695  1.93948   16.40705  0.574 25.67049 ? 247 LYS F CD     1 
ATOM   2355 C  CE     . LYS C 3 83 ? 18.37913  0.84732   17.47210  0.376 23.45275 ? 247 LYS F CE     1 
ATOM   2356 N  NZ     . LYS C 3 83 ? 17.12169  0.16315   17.87996  0.433 25.21512 ? 247 LYS F NZ     1 
ATOM   2357 H  H      . LYS C 3 83 ? 20.26329  -1.19679  13.46484  1.000 23.87446 ? 247 LYS F H      1 
ATOM   2358 H  HA     . LYS C 3 83 ? 17.71042  -0.76605  13.48556  1.000 22.23719 ? 247 LYS F HA     1 
ATOM   2359 H  HB2    . LYS C 3 83 ? 19.35969  0.07485   15.06667  1.000 24.52288 ? 247 LYS F HB2    1 
ATOM   2360 H  HB3    . LYS C 3 83 ? 19.56530  1.27502   14.04553  0.977 24.52288 ? 247 LYS F HB3    1 
ATOM   2361 H  HG2    . LYS C 3 83 ? 17.53208  2.11455   14.47284  1.000 29.29646 ? 247 LYS F HG2    1 
ATOM   2362 H  HG3    . LYS C 3 83 ? 17.04481  0.77171   15.16909  1.000 29.29646 ? 247 LYS F HG3    1 
ATOM   2363 H  HD2    . LYS C 3 83 ? 19.02320  2.42327   16.32030  0.963 30.80458 ? 247 LYS F HD2    1 
ATOM   2364 H  HD3    . LYS C 3 83 ? 17.48799  2.53762   16.71458  1.000 30.80458 ? 247 LYS F HD3    1 
ATOM   2365 H  HE2    . LYS C 3 83 ? 18.97949  0.17193   17.11953  1.000 28.14330 ? 247 LYS F HE2    1 
ATOM   2366 H  HE3    . LYS C 3 83 ? 18.76380  1.25153   18.26554  0.914 28.14330 ? 247 LYS F HE3    1 
ATOM   2367 H  HZ1    . LYS C 3 83 ? 17.30401  -0.49169  18.45446  1.000 30.25815 ? 247 LYS F HZ1    1 
ATOM   2368 H  HZ2    . LYS C 3 83 ? 16.57152  0.74426   18.26948  0.944 30.25815 ? 247 LYS F HZ2    1 
ATOM   2369 H  HZ3    . LYS C 3 83 ? 16.71811  -0.18287  17.16618  1.000 30.25815 ? 247 LYS F HZ3    1 
ATOM   2370 N  N      . LEU C 3 84 ? 16.91217  0.58025   11.62596  1.000 14.33459 ? 248 LEU F N      1 
ATOM   2371 C  CA     . LEU C 3 84 ? 16.39609  1.47156   10.58563  1.000 14.43919 ? 248 LEU F CA     1 
ATOM   2372 C  C      . LEU C 3 84 ? 17.07528  1.23487   9.23234   1.000 12.49122 ? 248 LEU F C      1 
ATOM   2373 O  O      . LEU C 3 84 ? 17.05747  2.11321   8.35419   1.000 13.06818 ? 248 LEU F O      1 
ATOM   2374 C  CB     . LEU C 3 84 ? 16.52000  2.94070   11.00967  1.000 12.93065 ? 248 LEU F CB     1 
ATOM   2375 C  CG     . LEU C 3 84 ? 15.63579  3.33085   12.20594  1.000 13.85248 ? 248 LEU F CG     1 
ATOM   2376 C  CD1    . LEU C 3 84 ? 16.01921  4.70106   12.74545  1.000 16.52549 ? 248 LEU F CD1    1 
ATOM   2377 C  CD2    . LEU C 3 84 ? 14.18476  3.34145   11.82060  1.000 17.67026 ? 248 LEU F CD2    1 
ATOM   2378 H  H      . LEU C 3 84 ? 16.30457  0.08086   11.97387  1.000 17.20151 ? 248 LEU F H      1 
ATOM   2379 H  HA     . LEU C 3 84 ? 15.45438  1.27549   10.46057  1.000 17.32703 ? 248 LEU F HA     1 
ATOM   2380 H  HB2    . LEU C 3 84 ? 17.44198  3.11460   11.25586  1.000 15.51677 ? 248 LEU F HB2    1 
ATOM   2381 H  HB3    . LEU C 3 84 ? 16.26539  3.50125   10.26010  1.000 15.51677 ? 248 LEU F HB3    1 
ATOM   2382 H  HG     . LEU C 3 84 ? 15.77137  2.67052   12.90343  1.000 16.62298 ? 248 LEU F HG     1 
ATOM   2383 H  HD11   . LEU C 3 84 ? 15.48479  4.89152   13.53223  1.000 19.83059 ? 248 LEU F HD11   1 
ATOM   2384 H  HD12   . LEU C 3 84 ? 16.96083  4.69660   12.97831  1.000 19.83059 ? 248 LEU F HD12   1 
ATOM   2385 H  HD13   . LEU C 3 84 ? 15.85071  5.36814   12.06171  1.000 19.83059 ? 248 LEU F HD13   1 
ATOM   2386 H  HD21   . LEU C 3 84 ? 13.66003  3.65273   12.57470  1.000 21.20431 ? 248 LEU F HD21   1 
ATOM   2387 H  HD22   . LEU C 3 84 ? 14.06311  3.93696   11.06465  1.000 21.20431 ? 248 LEU F HD22   1 
ATOM   2388 H  HD23   . LEU C 3 84 ? 13.91551  2.44135   11.57931  1.000 21.20431 ? 248 LEU F HD23   1 
ATOM   2389 N  N      . THR C 3 85 ? 17.58427  0.02556   9.02149   1.000 13.40251 ? 249 THR F N      1 
ATOM   2390 C  CA     . THR C 3 85 ? 18.38644  -0.30279  7.84103   1.000 11.57226 ? 249 THR F CA     1 
ATOM   2391 C  C      . THR C 3 85 ? 17.67524  -1.29760  6.93186   1.000 11.13527 ? 249 THR F C      1 
ATOM   2392 O  O      . THR C 3 85 ? 17.07235  -2.26294  7.39833   1.000 14.18955 ? 249 THR F O      1 
ATOM   2393 C  CB     . THR C 3 85 ? 19.75282  -0.84545  8.27926   1.000 14.86510 ? 249 THR F CB     1 
ATOM   2394 O  OG1    . THR C 3 85 ? 20.36957  0.12084   9.14383   1.000 17.98867 ? 249 THR F OG1    1 
ATOM   2395 C  CG2    . THR C 3 85 ? 20.66903  -1.06505  7.09225   1.000 14.09182 ? 249 THR F CG2    1 
ATOM   2396 H  H      . THR C 3 85 ? 17.47771  -0.63775  9.55839   1.000 16.08301 ? 249 THR F H      1 
ATOM   2397 H  HA     . THR C 3 85 ? 18.51635  0.49641   7.30690   1.000 13.88672 ? 249 THR F HA     1 
ATOM   2398 H  HB     . THR C 3 85 ? 19.62871  -1.69558  8.72956   1.000 17.83812 ? 249 THR F HB     1 
ATOM   2399 H  HG1    . THR C 3 85 ? 21.14375  -0.13127  9.35046   1.000 21.58641 ? 249 THR F HG1    1 
ATOM   2400 H  HG21   . THR C 3 85 ? 21.53748  -1.37248  7.39589   1.000 16.91019 ? 249 THR F HG21   1 
ATOM   2401 H  HG22   . THR C 3 85 ? 20.28903  -1.73152  6.49868   1.000 16.91019 ? 249 THR F HG22   1 
ATOM   2402 H  HG23   . THR C 3 85 ? 20.78230  -0.23539  6.60263   1.000 16.91019 ? 249 THR F HG23   1 
ATOM   2403 N  N      . TYR C 3 86 ? 17.76667  -1.04474  5.63093   1.000 11.52199 ? 250 TYR F N      1 
ATOM   2404 C  CA     . TYR C 3 86 ? 17.12702  -1.83437  4.59317   1.000 10.71693 ? 250 TYR F CA     1 
ATOM   2405 C  C      . TYR C 3 86 ? 18.11080  -2.04717  3.44243   1.000 12.19512 ? 250 TYR F C      1 
ATOM   2406 O  O      . TYR C 3 86 ? 19.18526  -1.44721  3.40029   1.000 11.69183 ? 250 TYR F O      1 
ATOM   2407 C  CB     . TYR C 3 86 ? 15.86622  -1.14573  4.06343   1.000 11.69799 ? 250 TYR F CB     1 
ATOM   2408 C  CG     . TYR C 3 86 ? 14.75375  -1.03157  5.05529   1.000 11.61045 ? 250 TYR F CG     1 
ATOM   2409 C  CD1    . TYR C 3 86 ? 14.77650  -0.04981  6.05153   1.000 13.64622 ? 250 TYR F CD1    1 
ATOM   2410 C  CD2    . TYR C 3 86 ? 13.67602  -1.89684  5.01184   1.000 13.23653 ? 250 TYR F CD2    1 
ATOM   2411 C  CE1    . TYR C 3 86 ? 13.75642  0.05762   6.96080   1.000 17.09776 ? 250 TYR F CE1    1 
ATOM   2412 C  CE2    . TYR C 3 86 ? 12.66007  -1.79629  5.91177   1.000 13.32783 ? 250 TYR F CE2    1 
ATOM   2413 C  CZ     . TYR C 3 86 ? 12.69708  -0.82593  6.88459   1.000 17.81107 ? 250 TYR F CZ     1 
ATOM   2414 O  OH     . TYR C 3 86 ? 11.66804  -0.74155  7.79841   1.000 15.23257 ? 250 TYR F OH     1 
ATOM   2415 H  H      . TYR C 3 86 ? 18.21767  -0.38636  5.31041   1.000 13.82639 ? 250 TYR F H      1 
ATOM   2416 H  HA     . TYR C 3 86 ? 16.88632  -2.69785  4.96379   1.000 12.86031 ? 250 TYR F HA     1 
ATOM   2417 H  HB2    . TYR C 3 86 ? 16.10055  -0.24733  3.78261   1.000 14.03759 ? 250 TYR F HB2    1 
ATOM   2418 H  HB3    . TYR C 3 86 ? 15.53240  -1.65325  3.30720   1.000 14.03759 ? 250 TYR F HB3    1 
ATOM   2419 H  HD1    . TYR C 3 86 ? 15.49481  0.53908   6.09764   1.000 16.37546 ? 250 TYR F HD1    1 
ATOM   2420 H  HD2    . TYR C 3 86 ? 13.64498  -2.55735  4.35788   1.000 15.88384 ? 250 TYR F HD2    1 
ATOM   2421 H  HE1    . TYR C 3 86 ? 13.77709  0.71479   7.61853   1.000 20.51731 ? 250 TYR F HE1    1 
ATOM   2422 H  HE2    . TYR C 3 86 ? 11.94074  -2.38416  5.86854   1.000 15.99340 ? 250 TYR F HE2    1 
ATOM   2423 H  HH     . TYR C 3 86 ? 11.11493  -1.35974  7.66613   1.000 18.27908 ? 250 TYR F HH     1 
ATOM   2424 N  N      . GLN C 3 87 ? 17.72298  -2.89019  2.48423   1.000 12.17825 ? 251 GLN F N      1 
ATOM   2425 C  CA     . GLN C 3 87 ? 18.59126  -3.23222  1.35963   1.000 12.42151 ? 251 GLN F CA     1 
ATOM   2426 C  C      . GLN C 3 87 ? 17.79354  -3.38454  0.07394   1.000 12.12336 ? 251 GLN F C      1 
ATOM   2427 O  O      . GLN C 3 87 ? 16.83513  -4.16507  0.01260   1.000 12.46059 ? 251 GLN F O      1 
ATOM   2428 C  CB     . GLN C 3 87 ? 19.37425  -4.51824  1.65413   1.000 14.41583 ? 251 GLN F CB     1 
ATOM   2429 C  CG     . GLN C 3 87 ? 20.42493  -4.82069  0.62558   1.000 17.33967 ? 251 GLN F CG     1 
ATOM   2430 C  CD     . GLN C 3 87 ? 21.30733  -6.00346  1.02934   1.000 20.62029 ? 251 GLN F CD     1 
ATOM   2431 O  OE1    . GLN C 3 87 ? 20.97361  -6.75935  1.93935   1.000 23.08738 ? 251 GLN F OE1    1 
ATOM   2432 N  NE2    . GLN C 3 87 ? 22.44402  -6.15654  0.35427   1.000 18.61877 ? 251 GLN F NE2    1 
ATOM   2433 H  H      . GLN C 3 87 ? 16.95609  -3.27888  2.46436   1.000 14.61390 ? 251 GLN F H      1 
ATOM   2434 H  HA     . GLN C 3 87 ? 19.20556  -2.49474  1.21949   1.000 14.90581 ? 251 GLN F HA     1 
ATOM   2435 H  HB2    . GLN C 3 87 ? 19.81525  -4.42733  2.51329   1.000 17.29899 ? 251 GLN F HB2    1 
ATOM   2436 H  HB3    . GLN C 3 87 ? 18.75499  -5.26451  1.67640   1.000 17.29899 ? 251 GLN F HB3    1 
ATOM   2437 H  HG2    . GLN C 3 87 ? 19.99336  -5.03895  -0.21526  1.000 20.80760 ? 251 GLN F HG2    1 
ATOM   2438 H  HG3    . GLN C 3 87 ? 20.99420  -4.04323  0.51431   1.000 20.80760 ? 251 GLN F HG3    1 
ATOM   2439 H  HE21   . GLN C 3 87 ? 22.64935  -5.60496  -0.27279  1.000 22.34252 ? 251 GLN F HE21   1 
ATOM   2440 H  HE22   . GLN C 3 87 ? 22.97321  -6.80703  0.54510   1.000 22.34252 ? 251 GLN F HE22   1 
ATOM   2441 N  N      . PHE C 3 88 ? 18.18790  -2.63061  -0.95538  1.000 11.96438 ? 252 PHE F N      1 
ATOM   2442 C  CA     . PHE C 3 88 ? 17.61532  -2.79307  -2.27863  1.000 12.10753 ? 252 PHE F CA     1 
ATOM   2443 C  C      . PHE C 3 88 ? 18.13409  -4.06006  -2.94343  1.000 15.63229 ? 252 PHE F C      1 
ATOM   2444 O  O      . PHE C 3 88 ? 19.27091  -4.48291  -2.71405  1.000 14.71756 ? 252 PHE F O      1 
ATOM   2445 C  CB     . PHE C 3 88 ? 17.96842  -1.62086  -3.18069  1.000 10.28991 ? 252 PHE F CB     1 
ATOM   2446 C  CG     . PHE C 3 88 ? 17.36706  -0.31520  -2.78175  1.000 12.00555 ? 252 PHE F CG     1 
ATOM   2447 C  CD1    . PHE C 3 88 ? 15.99589  -0.10123  -2.85981  1.000 14.29392 ? 252 PHE F CD1    1 
ATOM   2448 C  CD2    . PHE C 3 88 ? 18.18445  0.72802   -2.39416  1.000 13.63837 ? 252 PHE F CD2    1 
ATOM   2449 C  CE1    . PHE C 3 88 ? 15.45157  1.11937   -2.51066  1.000 13.34231 ? 252 PHE F CE1    1 
ATOM   2450 C  CE2    . PHE C 3 88 ? 17.63824  1.97018   -2.04915  1.000 13.20068 ? 252 PHE F CE2    1 
ATOM   2451 C  CZ     . PHE C 3 88 ? 16.26647  2.15848   -2.11333  1.000 15.56104 ? 252 PHE F CZ     1 
ATOM   2452 H  H      . PHE C 3 88 ? 18.78854  -2.01703  -0.90687  1.000 14.35726 ? 252 PHE F H      1 
ATOM   2453 H  HA     . PHE C 3 88 ? 16.65141  -2.84185  -2.18165  1.000 14.52904 ? 252 PHE F HA     1 
ATOM   2454 H  HB2    . PHE C 3 88 ? 18.93209  -1.51025  -3.17745  1.000 12.34789 ? 252 PHE F HB2    1 
ATOM   2455 H  HB3    . PHE C 3 88 ? 17.66043  -1.82063  -4.07854  1.000 12.34789 ? 252 PHE F HB3    1 
ATOM   2456 H  HD1    . PHE C 3 88 ? 15.43902  -0.78714  -3.15019  1.000 17.15270 ? 252 PHE F HD1    1 
ATOM   2457 H  HD2    . PHE C 3 88 ? 19.10565  0.60451   -2.36201  1.000 16.36604 ? 252 PHE F HD2    1 
ATOM   2458 H  HE1    . PHE C 3 88 ? 14.53017  1.24109   -2.54374  1.000 16.01077 ? 252 PHE F HE1    1 
ATOM   2459 H  HE2    . PHE C 3 88 ? 18.19314  2.66558   -1.77822  1.000 15.84082 ? 252 PHE F HE2    1 
ATOM   2460 H  HZ     . PHE C 3 88 ? 15.89721  2.98213   -1.88937  1.000 18.67325 ? 252 PHE F HZ     1 
ATOM   2461 N  N      . SER C 3 89 ? 17.30809  -4.63877  -3.81501  1.000 13.26817 ? 253 SER F N      1 
ATOM   2462 C  CA     . SER C 3 89 ? 17.76361  -5.76450  -4.62279  1.000 14.39445 ? 253 SER F CA     1 
ATOM   2463 C  C      . SER C 3 89 ? 18.70369  -5.29788  -5.72593  1.000 18.33728 ? 253 SER F C      1 
ATOM   2464 O  O      . SER C 3 89 ? 18.69817  -4.13921  -6.13719  1.000 15.27230 ? 253 SER F O      1 
ATOM   2465 C  CB     . SER C 3 89 ? 16.59510  -6.46952  -5.29192  1.000 12.32526 ? 253 SER F CB     1 
ATOM   2466 O  OG     . SER C 3 89 ? 16.06890  -5.64274  -6.28862  1.000 15.89858 ? 253 SER F OG     1 
ATOM   2467 H  H      . SER C 3 89 ? 16.49329  -4.40133  -3.95400  1.000 15.92180 ? 253 SER F H      1 
ATOM   2468 H  HA     . SER C 3 89 ? 18.22338  -6.38376  -4.03455  1.000 17.27334 ? 253 SER F HA     1 
ATOM   2469 H  HB2    . SER C 3 89 ? 16.90406  -7.29816  -5.69043  1.000 14.79031 ? 253 SER F HB2    1 
ATOM   2470 H  HB3    . SER C 3 89 ? 15.90929  -6.65455  -4.63136  1.000 14.79031 ? 253 SER F HB3    1 
ATOM   2471 H  HG     . SER C 3 89 ? 15.43881  -6.03373  -6.68322  1.000 19.07830 ? 253 SER F HG     1 
ATOM   2472 N  N      . GLY C 3 90 ? 19.48604  -6.24755  -6.24871  1.000 17.43065 ? 254 GLY F N      1 
ATOM   2473 C  CA     . GLY C 3 90 ? 20.32204  -5.93866  -7.39580  1.000 17.34936 ? 254 GLY F CA     1 
ATOM   2474 C  C      . GLY C 3 90 ? 19.51160  -5.48845  -8.58951  1.000 19.57677 ? 254 GLY F C      1 
ATOM   2475 O  O      . GLY C 3 90 ? 19.93032  -4.59345  -9.33514  1.000 21.40175 ? 254 GLY F O      1 
ATOM   2476 H  H      . GLY C 3 90 ? 19.54578  -7.05596  -5.96147  1.000 20.91678 ? 254 GLY F H      1 
ATOM   2477 H  HA2    . GLY C 3 90 ? 20.94122  -5.22989  -7.16092  1.000 20.81923 ? 254 GLY F HA2    1 
ATOM   2478 H  HA3    . GLY C 3 90 ? 20.82642  -6.72791  -7.64797  1.000 20.81923 ? 254 GLY F HA3    1 
ATOM   2479 N  N      . GLU C 3 91 ? 18.32967  -6.08270  -8.77941  1.000 19.58866 ? 255 GLU F N      1 
ATOM   2480 C  CA     . GLU C 3 91 ? 17.49470  -5.68754  -9.90217  1.000 22.90339 ? 255 GLU F CA     1 
ATOM   2481 C  C      . GLU C 3 91 ? 17.08881  -4.22224  -9.78135  1.000 20.22487 ? 255 GLU F C      1 
ATOM   2482 O  O      . GLU C 3 91 ? 17.14130  -3.46175  -10.76164 1.000 20.98500 ? 255 GLU F O      1 
ATOM   2483 C  CB     . GLU C 3 91 ? 16.26584  -6.59664  -9.97654  1.000 21.42209 ? 255 GLU F CB     1 
ATOM   2484 C  CG     . GLU C 3 91 ? 16.55559  -8.05164  -10.37927 1.000 28.38668 ? 255 GLU F CG     1 
ATOM   2485 C  CD     . GLU C 3 91 ? 16.99195  -8.97763  -9.24086  1.000 38.69346 ? 255 GLU F CD     1 
ATOM   2486 O  OE1    . GLU C 3 91 ? 17.29067  -8.51956  -8.10545  1.000 27.47963 ? 255 GLU F OE1    1 
ATOM   2487 O  OE2    . GLU C 3 91 ? 17.03756  -10.20188 -9.50654  0.625 25.97880 ? 255 GLU F OE2    1 
ATOM   2488 H  H      . GLU C 3 91 ? 18.00047  -6.70205  -8.28178  1.000 23.50639 ? 255 GLU F H      1 
ATOM   2489 H  HA     . GLU C 3 91 ? 17.98980  -5.79278  -10.72963 1.000 27.48406 ? 255 GLU F HA     1 
ATOM   2490 H  HB2    . GLU C 3 91 ? 15.84482  -6.61533  -9.10288  1.000 25.70650 ? 255 GLU F HB2    1 
ATOM   2491 H  HB3    . GLU C 3 91 ? 15.65250  -6.23021  -10.63262 1.000 25.70650 ? 255 GLU F HB3    1 
ATOM   2492 H  HG2    . GLU C 3 91 ? 15.74867  -8.42845  -10.76371 1.000 34.06401 ? 255 GLU F HG2    1 
ATOM   2493 H  HG3    . GLU C 3 91 ? 17.26753  -8.05004  -11.03809 1.000 34.06401 ? 255 GLU F HG3    1 
ATOM   2494 N  N      . VAL C 3 92 ? 16.69775  -3.80472  -8.57591  1.000 19.05501 ? 256 VAL F N      1 
ATOM   2495 C  CA     . VAL C 3 92 ? 16.30212  -2.42437  -8.34814  1.000 16.55083 ? 256 VAL F CA     1 
ATOM   2496 C  C      . VAL C 3 92 ? 17.46615  -1.48627  -8.61067  1.000 19.67971 ? 256 VAL F C      1 
ATOM   2497 O  O      . VAL C 3 92 ? 17.27213  -0.36459  -9.08641  1.000 18.02465 ? 256 VAL F O      1 
ATOM   2498 C  CB     . VAL C 3 92 ? 15.74402  -2.27602  -6.91446  1.000 15.10619 ? 256 VAL F CB     1 
ATOM   2499 C  CG1    . VAL C 3 92 ? 15.69758  -0.83707  -6.49037  1.000 16.99160 ? 256 VAL F CG1    1 
ATOM   2500 C  CG2    . VAL C 3 92 ? 14.34710  -2.87105  -6.86667  1.000 25.18045 ? 256 VAL F CG2    1 
ATOM   2501 H  H      . VAL C 3 92 ? 16.65405  -4.30336  -7.87659  1.000 22.86601 ? 256 VAL F H      1 
ATOM   2502 H  HA     . VAL C 3 92 ? 15.59553  -2.18627  -8.96858  1.000 19.86100 ? 256 VAL F HA     1 
ATOM   2503 H  HB     . VAL C 3 92 ? 16.32814  -2.74417  -6.29756  1.000 18.12743 ? 256 VAL F HB     1 
ATOM   2504 H  HG11   . VAL C 3 92 ? 15.12659  -0.75597  -5.71044  1.000 20.38992 ? 256 VAL F HG11   1 
ATOM   2505 H  HG12   . VAL C 3 92 ? 16.59615  -0.54227  -6.27457  1.000 20.38992 ? 256 VAL F HG12   1 
ATOM   2506 H  HG13   . VAL C 3 92 ? 15.34067  -0.30464  -7.21841  1.000 20.38992 ? 256 VAL F HG13   1 
ATOM   2507 H  HG21   . VAL C 3 92 ? 14.01351  -2.82110  -5.95721  1.000 30.21654 ? 256 VAL F HG21   1 
ATOM   2508 H  HG22   . VAL C 3 92 ? 13.76843  -2.36640  -7.45944  1.000 30.21654 ? 256 VAL F HG22   1 
ATOM   2509 H  HG23   . VAL C 3 92 ? 14.38816  -3.79675  -7.15356  1.000 30.21654 ? 256 VAL F HG23   1 
ATOM   2510 N  N      . LEU C 3 93 ? 18.68390  -1.92927  -8.31708  1.000 18.06244 ? 257 LEU F N      1 
ATOM   2511 C  CA     . LEU C 3 93 ? 19.86319  -1.06706  -8.40129  1.000 18.64914 ? 257 LEU F CA     1 
ATOM   2512 C  C      . LEU C 3 93 ? 20.41655  -0.94548  -9.81849  1.000 23.57608 ? 257 LEU F C      1 
ATOM   2513 O  O      . LEU C 3 93 ? 21.14756  0.01199   -10.10263 1.000 24.68628 ? 257 LEU F O      1 
ATOM   2514 C  CB     . LEU C 3 93 ? 20.94236  -1.59929  -7.46873  1.000 20.61605 ? 257 LEU F CB     1 
ATOM   2515 C  CG     . LEU C 3 93 ? 20.56047  -1.52913  -5.99203  1.000 20.64606 ? 257 LEU F CG     1 
ATOM   2516 C  CD1    . LEU C 3 93 ? 21.52189  -2.37162  -5.17788  1.000 24.31915 ? 257 LEU F CD1    1 
ATOM   2517 C  CD2    . LEU C 3 93 ? 20.53716  -0.08201  -5.52157  1.000 23.29551 ? 257 LEU F CD2    1 
ATOM   2518 H  H      . LEU C 3 93 ? 18.85886  -2.73231  -8.06387  1.000 21.67493 ? 257 LEU F H      1 
ATOM   2519 H  HA     . LEU C 3 93 ? 19.62113  -0.17304  -8.11311  1.000 22.37897 ? 257 LEU F HA     1 
ATOM   2520 H  HB2    . LEU C 3 93 ? 21.11394  -2.52844  -7.68812  1.000 24.73926 ? 257 LEU F HB2    1 
ATOM   2521 H  HB3    . LEU C 3 93 ? 21.74874  -1.07469  -7.59303  1.000 24.73926 ? 257 LEU F HB3    1 
ATOM   2522 H  HG     . LEU C 3 93 ? 19.66842  -1.88586  -5.85833  1.000 24.77528 ? 257 LEU F HG     1 
ATOM   2523 H  HD11   . LEU C 3 93 ? 21.18636  -2.44606  -4.27081  1.000 29.18298 ? 257 LEU F HD11   1 
ATOM   2524 H  HD12   . LEU C 3 93 ? 21.58811  -3.25214  -5.57937  1.000 29.18298 ? 257 LEU F HD12   1 
ATOM   2525 H  HD13   . LEU C 3 93 ? 22.39220  -1.94331  -5.17452  1.000 29.18298 ? 257 LEU F HD13   1 
ATOM   2526 H  HD21   . LEU C 3 93 ? 20.38325  -0.06367  -4.56403  1.000 27.95461 ? 257 LEU F HD21   1 
ATOM   2527 H  HD22   . LEU C 3 93 ? 21.39049  0.33076   -5.72739  1.000 27.95461 ? 257 LEU F HD22   1 
ATOM   2528 H  HD23   . LEU C 3 93 ? 19.82324  0.38777   -5.98040  1.000 27.95461 ? 257 LEU F HD23   1 
ATOM   2529 N  N      . GLY C 3 94 ? 20.06734  -1.86691  -10.70962 1.000 27.54849 ? 258 GLY F N      1 
ATOM   2530 C  CA     . GLY C 3 94 ? 20.53042  -1.83266  -12.09203 1.000 31.12271 ? 258 GLY F CA     1 
ATOM   2531 C  C      . GLY C 3 94 ? 20.35164  -0.49995  -12.80074 1.000 37.21077 ? 258 GLY F C      1 
ATOM   2532 O  O      . GLY C 3 94 ? 19.23518  0.00816   -12.95415 1.000 42.86784 ? 258 GLY F O      1 
ATOM   2533 H  H      . GLY C 3 94 ? 19.55375  -2.53437  -10.53550 1.000 33.05819 ? 258 GLY F H      1 
ATOM   2534 H  HA2    . GLY C 3 94 ? 21.47577  -2.04939  -12.10765 1.000 37.34725 ? 258 GLY F HA2    1 
ATOM   2535 H  HA3    . GLY C 3 94 ? 20.04449  -2.50232  -12.59832 1.000 37.34725 ? 258 GLY F HA3    1 
HETATM 2536 NA NA     . NA  D 4 .  ? 10.04848  4.10964   15.35360  1.000 49.59264 ? 101 NA  C NA     1 
HETATM 2537 O  O      . HOH E 5 .  ? 11.93418  0.44429   10.32594  1.000 24.16020 ? 201 HOH C O      1 
HETATM 2538 O  O      . HOH E 5 .  ? 4.30026   9.22813   27.03892  1.000 40.14278 ? 202 HOH C O      1 
HETATM 2539 O  O      . HOH E 5 .  ? -14.74892 -1.09999  8.04941   1.000 41.53999 ? 203 HOH C O      1 
HETATM 2540 O  O      . HOH E 5 .  ? -10.03201 -8.30331  4.29751   1.000 31.30244 ? 204 HOH C O      1 
HETATM 2541 O  O      . HOH E 5 .  ? 3.76443   10.27701  31.54350  1.000 29.23897 ? 205 HOH C O      1 
HETATM 2542 O  O      . HOH E 5 .  ? 8.86624   -8.85508  7.16814   1.000 34.94352 ? 206 HOH C O      1 
HETATM 2543 O  O      . HOH E 5 .  ? 14.39646  -7.98985  10.75478  1.000 28.58658 ? 207 HOH C O      1 
HETATM 2544 O  O      . HOH E 5 .  ? 4.15799   1.12892   17.03754  1.000 41.27603 ? 208 HOH C O      1 
HETATM 2545 O  O      . HOH E 5 .  ? 2.97810   -0.80078  10.96210  1.000 13.99445 ? 209 HOH C O      1 
HETATM 2546 O  O      . HOH E 5 .  ? -8.86582  -4.60169  -2.22921  1.000 31.89020 ? 210 HOH C O      1 
HETATM 2547 O  O      . HOH E 5 .  ? -6.22561  -5.99355  -0.01758  1.000 35.33303 ? 211 HOH C O      1 
HETATM 2548 O  O      . HOH E 5 .  ? 4.85824   -1.16718  33.46284  1.000 21.18441 ? 212 HOH C O      1 
HETATM 2549 O  O      . HOH E 5 .  ? 6.57063   -12.77060 11.70828  1.000 49.02051 ? 213 HOH C O      1 
HETATM 2550 O  O      . HOH E 5 .  ? -4.66467  8.43789   -13.31933 1.000 42.66842 ? 214 HOH C O      1 
HETATM 2551 O  O      . HOH E 5 .  ? 5.54466   2.81264   22.03820  1.000 36.97105 ? 215 HOH C O      1 
HETATM 2552 O  O      . HOH E 5 .  ? 9.98647   -2.78914  9.40915   1.000 17.81991 ? 216 HOH C O      1 
HETATM 2553 O  O      . HOH E 5 .  ? -8.72110  -0.34245  6.80095   1.000 27.86265 ? 217 HOH C O      1 
HETATM 2554 O  O      . HOH E 5 .  ? -17.16717 -2.65417  4.85456   1.000 19.13596 ? 218 HOH C O      1 
HETATM 2555 O  O      . HOH E 5 .  ? -12.55599 6.66130   0.16582   1.000 30.82139 ? 219 HOH C O      1 
HETATM 2556 O  O      . HOH E 5 .  ? -0.81712  -9.15605  12.52224  1.000 25.33193 ? 220 HOH C O      1 
HETATM 2557 O  O      . HOH E 5 .  ? 16.60144  -2.99531  14.81273  1.000 27.41316 ? 221 HOH C O      1 
HETATM 2558 O  O      . HOH E 5 .  ? -12.30019 5.29346   4.65570   1.000 24.58918 ? 222 HOH C O      1 
HETATM 2559 O  O      . HOH E 5 .  ? -9.39589  -5.51471  1.22421   1.000 27.47374 ? 223 HOH C O      1 
HETATM 2560 O  O      . HOH E 5 .  ? 3.99282   7.98009   35.08179  1.000 20.55641 ? 224 HOH C O      1 
HETATM 2561 O  O      . HOH E 5 .  ? 3.10015   -9.27277  14.30526  1.000 30.35674 ? 225 HOH C O      1 
HETATM 2562 O  O      . HOH E 5 .  ? -15.36040 6.00342   2.35378   1.000 24.02122 ? 226 HOH C O      1 
HETATM 2563 O  O      . HOH E 5 .  ? -3.09381  0.64857   -10.33225 1.000 28.82074 ? 227 HOH C O      1 
HETATM 2564 O  O      . HOH E 5 .  ? -5.19597  -8.11521  12.48208  1.000 42.99144 ? 228 HOH C O      1 
HETATM 2565 O  O      . HOH E 5 .  ? 10.96718  -9.78324  9.33428   1.000 40.61779 ? 229 HOH C O      1 
HETATM 2566 O  O      . HOH E 5 .  ? 9.52373   6.21481   32.66177  1.000 27.04028 ? 230 HOH C O      1 
HETATM 2567 O  O      . HOH E 5 .  ? -11.31687 4.99372   -5.61468  1.000 25.76047 ? 231 HOH C O      1 
HETATM 2568 O  O      . HOH E 5 .  ? -10.42509 -12.03547 6.76196   1.000 41.53328 ? 232 HOH C O      1 
HETATM 2569 O  O      . HOH E 5 .  ? 4.50035   4.75308   28.37089  1.000 24.33151 ? 233 HOH C O      1 
HETATM 2570 O  O      . HOH E 5 .  ? -3.49735  9.03585   -11.07553 1.000 39.61018 ? 234 HOH C O      1 
HETATM 2571 O  O      . HOH E 5 .  ? 6.60191   3.05738   17.94332  1.000 35.67032 ? 235 HOH C O      1 
HETATM 2572 O  O      . HOH E 5 .  ? 13.69887  0.42371   19.85036  1.000 29.28077 ? 236 HOH C O      1 
HETATM 2573 O  O      . HOH E 5 .  ? -8.30830  10.22201  -4.67013  1.000 40.65228 ? 237 HOH C O      1 
HETATM 2574 O  O      . HOH E 5 .  ? 8.79769   6.23630   16.25754  1.000 39.89869 ? 238 HOH C O      1 
HETATM 2575 O  O      . HOH E 5 .  ? -8.37744  -3.74394  9.96409   1.000 28.45283 ? 239 HOH C O      1 
HETATM 2576 O  O      . HOH E 5 .  ? 5.58304   -0.33599  26.69043  1.000 35.52086 ? 240 HOH C O      1 
HETATM 2577 O  O      . HOH E 5 .  ? 14.34300  3.62964   25.36239  1.000 30.12831 ? 241 HOH C O      1 
HETATM 2578 O  O      . HOH E 5 .  ? 13.07816  6.23332   27.18665  1.000 32.98545 ? 242 HOH C O      1 
HETATM 2579 O  O      . HOH E 5 .  ? 5.618     0.938     29.488    1.000 32.69116 ? 243 HOH C O      1 
HETATM 2580 O  O      . HOH E 5 .  ? -2.82280  -1.68038  -11.88090 1.000 30.64114 ? 244 HOH C O      1 
HETATM 2581 O  O      . HOH E 5 .  ? 10.68432  -6.93597  7.35334   1.000 28.03046 ? 245 HOH C O      1 
HETATM 2582 O  O      . HOH E 5 .  ? 4.90790   0.63778   23.93976  1.000 31.21901 ? 246 HOH C O      1 
HETATM 2583 O  O      . HOH E 5 .  ? 7.91102   6.65632   20.15650  1.000 39.85606 ? 247 HOH C O      1 
HETATM 2584 O  O      . HOH E 5 .  ? -3.74979  -6.98267  2.39941   1.000 34.97884 ? 248 HOH C O      1 
HETATM 2585 O  O      . HOH E 5 .  ? -9.29636  5.59796   -9.88854  1.000 24.85831 ? 249 HOH C O      1 
HETATM 2586 O  O      . HOH E 5 .  ? 14.18018  3.44037   22.57055  1.000 31.25784 ? 250 HOH C O      1 
HETATM 2587 O  O      . HOH E 5 .  ? -2.97638  2.93987   -7.78426  1.000 31.44179 ? 251 HOH C O      1 
HETATM 2588 O  O      . HOH E 5 .  ? -7.24287  -6.61987  11.82910  1.000 35.05921 ? 252 HOH C O      1 
HETATM 2589 O  O      . HOH E 5 .  ? -2.48283  8.01854   -6.80804  1.000 37.03311 ? 253 HOH C O      1 
HETATM 2590 O  O      . HOH E 5 .  ? -5.78102  4.07389   1.26859   1.000 21.77575 ? 254 HOH C O      1 
HETATM 2591 O  O      . HOH E 5 .  ? -1.87034  -6.80500  4.21417   1.000 28.91056 ? 255 HOH C O      1 
HETATM 2592 O  O      . HOH E 5 .  ? 6.29628   6.96899   24.58983  1.000 27.48160 ? 256 HOH C O      1 
HETATM 2593 O  O      . HOH E 5 .  ? -5.13902  4.73744   -1.01910  1.000 34.15565 ? 257 HOH C O      1 
HETATM 2594 O  O      . HOH E 5 .  ? 1.01660   -10.68551 13.82531  1.000 38.58043 ? 258 HOH C O      1 
HETATM 2595 O  O      . HOH E 5 .  ? 10.78543  8.59255   16.98284  1.000 45.36234 ? 259 HOH C O      1 
HETATM 2596 O  O      . HOH E 5 .  ? -8.41542  2.44417   5.90100   1.000 25.58058 ? 260 HOH C O      1 
HETATM 2597 O  O      . HOH E 5 .  ? -10.30723 -1.49617  8.93495   1.000 33.34106 ? 261 HOH C O      1 
HETATM 2598 O  O      . HOH E 5 .  ? -5.06421  -10.83019 13.72340  1.000 44.55261 ? 262 HOH C O      1 
HETATM 2599 O  O      . HOH E 5 .  ? 5.626     -1.126    30.388    1.000 29.37900 ? 263 HOH C O      1 
HETATM 2600 O  O      . HOH E 5 .  ? 16.20456  -5.15698  14.31955  1.000 38.82149 ? 264 HOH C O      1 
HETATM 2601 O  O      . HOH E 5 .  ? 3.95916   6.23850   25.98823  1.000 31.68100 ? 265 HOH C O      1 
HETATM 2602 O  O      . HOH E 5 .  ? 12.78680  -9.85985  7.29108   1.000 34.80411 ? 266 HOH C O      1 
HETATM 2603 O  O      . HOH E 5 .  ? -18.60720 -2.71294  7.42653   1.000 29.33901 ? 267 HOH C O      1 
HETATM 2604 O  O      . HOH F 5 .  ? -8.16993  -9.38809  -5.20387  1.000 36.33083 ? 101 HOH D O      1 
HETATM 2605 O  O      . HOH F 5 .  ? -10.07426 -8.49434  -12.48258 1.000 10.41915 ? 102 HOH D O      1 
HETATM 2606 O  O      . HOH F 5 .  ? 13.60942  -11.74042 23.87818  1.000 37.50071 ? 103 HOH D O      1 
HETATM 2607 O  O      . HOH F 5 .  ? -3.16814  7.30415   9.34032   1.000 19.76727 ? 104 HOH D O      1 
HETATM 2608 O  O      . HOH F 5 .  ? 4.00412   -13.36401 22.83719  1.000 41.65011 ? 105 HOH D O      1 
HETATM 2609 O  O      . HOH F 5 .  ? -4.31510  -0.90114  19.88683  1.000 44.25128 ? 106 HOH D O      1 
HETATM 2610 O  O      . HOH F 5 .  ? -0.88934  0.76264   17.57129  1.000 36.43650 ? 107 HOH D O      1 
HETATM 2611 O  O      . HOH F 5 .  ? 3.38344   -1.24170  22.37232  1.000 27.52904 ? 108 HOH D O      1 
HETATM 2612 O  O      . HOH F 5 .  ? 20.16973  -3.92994  26.13860  1.000 36.80127 ? 109 HOH D O      1 
HETATM 2613 O  O      . HOH F 5 .  ? -0.29917  -4.52799  3.39422   1.000 15.25562 ? 110 HOH D O      1 
HETATM 2614 O  O      . HOH F 5 .  ? -8.57257  -14.01320 -10.57646 1.000 33.58854 ? 111 HOH D O      1 
HETATM 2615 O  O      . HOH F 5 .  ? -2.39437  -6.17253  -2.84691  1.000 30.03840 ? 112 HOH D O      1 
HETATM 2616 O  O      . HOH F 5 .  ? 2.88043   3.88805   -4.83003  1.000 14.46457 ? 113 HOH D O      1 
HETATM 2617 O  O      . HOH F 5 .  ? -15.40267 -1.18377  -10.85133 1.000 19.13759 ? 114 HOH D O      1 
HETATM 2618 O  O      . HOH F 5 .  ? -11.51436 -15.77768 -10.83127 1.000 15.74484 ? 115 HOH D O      1 
HETATM 2619 O  O      . HOH F 5 .  ? 5.48513   -3.33474  25.67432  1.000 28.10875 ? 116 HOH D O      1 
HETATM 2620 O  O      . HOH F 5 .  ? -16.03714 -14.35972 -7.29783  1.000 37.19249 ? 117 HOH D O      1 
HETATM 2621 O  O      . HOH F 5 .  ? -0.21567  9.21235   3.70512   1.000 13.46660 ? 118 HOH D O      1 
HETATM 2622 O  O      . HOH F 5 .  ? 9.08354   -13.36458 24.94943  1.000 34.41235 ? 119 HOH D O      1 
HETATM 2623 O  O      . HOH F 5 .  ? -2.81647  -10.02649 24.13537  1.000 39.54509 ? 120 HOH D O      1 
HETATM 2624 O  O      . HOH F 5 .  ? -3.16048  -3.10286  23.87165  1.000 50.65879 ? 121 HOH D O      1 
HETATM 2625 O  O      . HOH F 5 .  ? -6.94180  2.47453   3.49211   1.000 15.96885 ? 122 HOH D O      1 
HETATM 2626 O  O      . HOH F 5 .  ? -7.67712  -2.66925  12.32689  1.000 34.41628 ? 123 HOH D O      1 
HETATM 2627 O  O      . HOH F 5 .  ? -10.11107 6.08355   8.17242   1.000 30.07589 ? 124 HOH D O      1 
HETATM 2628 O  O      . HOH F 5 .  ? 2.44457   -5.17129  -5.95524  1.000 27.61854 ? 125 HOH D O      1 
HETATM 2629 O  O      . HOH F 5 .  ? 9.38568   -6.41135  17.31016  1.000 39.69721 ? 126 HOH D O      1 
HETATM 2630 O  O      . HOH F 5 .  ? 5.83490   -12.08860 24.49482  1.000 30.56379 ? 127 HOH D O      1 
HETATM 2631 O  O      . HOH F 5 .  ? -4.75467  -5.75295  15.21295  1.000 30.40120 ? 128 HOH D O      1 
HETATM 2632 O  O      . HOH F 5 .  ? -3.27746  2.92311   -1.87878  1.000 16.93049 ? 129 HOH D O      1 
HETATM 2633 O  O      . HOH F 5 .  ? 14.26966  -7.50784  25.32858  1.000 21.04806 ? 130 HOH D O      1 
HETATM 2634 O  O      . HOH F 5 .  ? 3.25501   -8.74187  16.91605  1.000 31.08145 ? 131 HOH D O      1 
HETATM 2635 O  O      . HOH F 5 .  ? 18.587    -8.909    22.490    1.000 48.62513 ? 132 HOH D O      1 
HETATM 2636 O  O      . HOH F 5 .  ? -13.61629 -11.64554 -6.06608  1.000 33.62213 ? 133 HOH D O      1 
HETATM 2637 O  O      . HOH F 5 .  ? -4.75007  -6.11425  -2.25136  1.000 29.46542 ? 134 HOH D O      1 
HETATM 2638 O  O      . HOH F 5 .  ? -1.55361  -6.32576  0.46700   1.000 35.88327 ? 135 HOH D O      1 
HETATM 2639 O  O      . HOH F 5 .  ? -14.483   -2.719    -7.591    1.000 23.03981 ? 136 HOH D O      1 
HETATM 2640 O  O      . HOH F 5 .  ? -4.69313  -5.49147  -12.33500 1.000 27.10236 ? 137 HOH D O      1 
HETATM 2641 O  O      . HOH F 5 .  ? 1.62187   2.81725   3.54051   1.000 11.51109 ? 138 HOH D O      1 
HETATM 2642 O  O      . HOH F 5 .  ? -13.62842 -9.34362  -14.88272 1.000 22.31577 ? 139 HOH D O      1 
HETATM 2643 O  O      . HOH F 5 .  ? -1.41207  0.53852   -8.49071  1.000 36.85826 ? 140 HOH D O      1 
HETATM 2644 O  O      . HOH F 5 .  ? -11.20630 -5.09583  -5.31389  1.000 30.28256 ? 141 HOH D O      1 
HETATM 2645 O  O      . HOH F 5 .  ? 4.56263   -8.38858  24.38530  1.000 29.08794 ? 142 HOH D O      1 
HETATM 2646 O  O      . HOH F 5 .  ? -7.20064  -6.00348  -3.88581  1.000 28.23812 ? 143 HOH D O      1 
HETATM 2647 O  O      . HOH F 5 .  ? -4.69650  2.51942   16.17511  1.000 44.17132 ? 144 HOH D O      1 
HETATM 2648 O  O      . HOH F 5 .  ? -7.74672  -9.23011  -11.81053 1.000 23.04231 ? 145 HOH D O      1 
HETATM 2649 O  O      . HOH F 5 .  ? 15.05896  -0.95341  21.46396  1.000 27.79759 ? 146 HOH D O      1 
HETATM 2650 O  O      . HOH F 5 .  ? -2.27357  -7.62342  16.58709  1.000 29.63682 ? 147 HOH D O      1 
HETATM 2651 O  O      . HOH F 5 .  ? -19.38778 -6.71422  -10.76670 1.000 23.51821 ? 148 HOH D O      1 
HETATM 2652 O  O      . HOH F 5 .  ? 1.09557   0.91989   9.69542   1.000 11.31547 ? 149 HOH D O      1 
HETATM 2653 O  O      . HOH F 5 .  ? -0.92629  2.16740   -5.26697  1.000 35.97359 ? 150 HOH D O      1 
HETATM 2654 O  O      . HOH F 5 .  ? 2.39560   -7.84609  -9.28986  1.000 41.54503 ? 151 HOH D O      1 
HETATM 2655 O  O      . HOH F 5 .  ? 8.13040   -12.93760 18.24661  1.000 45.13353 ? 152 HOH D O      1 
HETATM 2656 O  O      . HOH F 5 .  ? -11.22065 -10.07204 -13.64816 1.000 22.17328 ? 153 HOH D O      1 
HETATM 2657 O  O      . HOH F 5 .  ? -3.695    -6.370    26.005    1.000 49.88825 ? 154 HOH D O      1 
HETATM 2658 O  O      . HOH F 5 .  ? -9.32683  6.65398   12.67052  1.000 41.42896 ? 155 HOH D O      1 
HETATM 2659 O  O      . HOH F 5 .  ? -0.73752  -9.18543  15.70843  1.000 44.29454 ? 156 HOH D O      1 
HETATM 2660 O  O      . HOH F 5 .  ? 0.85555   -9.61781  16.84450  1.000 42.97072 ? 157 HOH D O      1 
HETATM 2661 O  O      . HOH F 5 .  ? 1.10991   3.09268   -6.62761  1.000 25.99415 ? 158 HOH D O      1 
HETATM 2662 O  O      . HOH F 5 .  ? 2.80168   -3.47860  -1.71090  1.000 22.27580 ? 159 HOH D O      1 
HETATM 2663 O  O      . HOH F 5 .  ? -3.411    -12.980   -6.098    1.000 29.42058 ? 160 HOH D O      1 
HETATM 2664 O  O      . HOH F 5 .  ? -5.76791  -7.90532  -13.17905 1.000 37.10056 ? 161 HOH D O      1 
HETATM 2665 O  O      . HOH F 5 .  ? -10.53546 -9.30845  -4.07986  1.000 41.61078 ? 162 HOH D O      1 
HETATM 2666 O  O      . HOH F 5 .  ? -1.06332  -0.57164  -11.22583 1.000 47.15296 ? 163 HOH D O      1 
HETATM 2667 O  O      . HOH F 5 .  ? 18.996    -8.205    24.523    1.000 51.63633 ? 164 HOH D O      1 
HETATM 2668 O  O      . HOH F 5 .  ? -3.29916  1.10649   20.43437  1.000 41.54390 ? 165 HOH D O      1 
HETATM 2669 O  O      . HOH F 5 .  ? 15.807    -11.738   26.989    1.000 44.35384 ? 166 HOH D O      1 
HETATM 2670 O  O      . HOH F 5 .  ? -1.96424  4.34504   10.80980  1.000 27.44167 ? 167 HOH D O      1 
HETATM 2671 O  O      . HOH F 5 .  ? -9.87880  -14.98782 -12.80527 1.000 37.37022 ? 168 HOH D O      1 
HETATM 2672 O  O      . HOH F 5 .  ? -0.242    -7.404    26.606    1.000 50.76164 ? 169 HOH D O      1 
HETATM 2673 O  O      . HOH F 5 .  ? -1.33736  -0.70621  21.55202  1.000 55.48413 ? 170 HOH D O      1 
HETATM 2674 O  O      . HOH F 5 .  ? -3.41833  1.72976   18.48840  1.000 47.84175 ? 171 HOH D O      1 
HETATM 2675 O  O      . HOH F 5 .  ? -13.88565 -8.78384  -6.37415  1.000 31.85143 ? 172 HOH D O      1 
HETATM 2676 O  O      . HOH F 5 .  ? -18.964   -5.848    -13.410   1.000 29.69148 ? 173 HOH D O      1 
HETATM 2677 O  O      . HOH F 5 .  ? -12.59781 6.78190   8.18859   1.000 47.13809 ? 174 HOH D O      1 
HETATM 2678 O  O      . HOH F 5 .  ? -8.47472  -9.26094  -1.82486  1.000 45.21685 ? 175 HOH D O      1 
HETATM 2679 O  O      . HOH F 5 .  ? -5.555    -10.127   -1.532    1.000 42.15957 ? 176 HOH D O      1 
HETATM 2680 O  O      . HOH G 5 .  ? -6.24035  6.88003   1.95226   1.000 36.64121 ? 301 HOH F O      1 
HETATM 2681 O  O      . HOH G 5 .  ? 28.57989  3.56283   5.72749   1.000 22.65735 ? 302 HOH F O      1 
HETATM 2682 O  O      . HOH G 5 .  ? 8.46790   14.88307  -3.46070  1.000 40.28744 ? 303 HOH F O      1 
HETATM 2683 O  O      . HOH G 5 .  ? 1.38304   0.77999   16.11913  1.000 33.77756 ? 304 HOH F O      1 
HETATM 2684 O  O      . HOH G 5 .  ? 16.32009  20.92629  -1.21988  1.000 39.39535 ? 305 HOH F O      1 
HETATM 2685 O  O      . HOH G 5 .  ? 9.41612   8.60540   14.41342  1.000 30.70921 ? 306 HOH F O      1 
HETATM 2686 O  O      . HOH G 5 .  ? 21.54210  -5.66795  -3.20163  1.000 21.91938 ? 307 HOH F O      1 
HETATM 2687 O  O      . HOH G 5 .  ? 30.371    -3.274    -6.043    1.000 38.63364 ? 308 HOH F O      1 
HETATM 2688 O  O      . HOH G 5 .  ? 24.20114  5.48704   11.44575  1.000 34.69536 ? 309 HOH F O      1 
HETATM 2689 O  O      . HOH G 5 .  ? 30.434    1.469     -1.616    1.000 25.53430 ? 310 HOH F O      1 
HETATM 2690 O  O      . HOH G 5 .  ? 20.46031  10.82955  1.15322   1.000 22.26475 ? 311 HOH F O      1 
HETATM 2691 O  O      . HOH G 5 .  ? 17.41837  11.18298  -7.95746  1.000 28.49784 ? 312 HOH F O      1 
HETATM 2692 O  O      . HOH G 5 .  ? 20.10402  11.83641  11.83969  1.000 27.30188 ? 313 HOH F O      1 
HETATM 2693 O  O      . HOH G 5 .  ? 22.39747  2.00550   -8.87572  1.000 21.28201 ? 314 HOH F O      1 
HETATM 2694 O  O      . HOH G 5 .  ? 9.12242   16.84369  4.56706   1.000 20.09128 ? 315 HOH F O      1 
HETATM 2695 O  O      . HOH G 5 .  ? 11.07775  -5.36840  3.06521   1.000 19.03863 ? 316 HOH F O      1 
HETATM 2696 O  O      . HOH G 5 .  ? 6.44321   -5.74899  -6.46043  1.000 27.08044 ? 317 HOH F O      1 
HETATM 2697 O  O      . HOH G 5 .  ? 18.45142  12.34742  0.21159   1.000 23.60568 ? 318 HOH F O      1 
HETATM 2698 O  O      . HOH G 5 .  ? 18.28633  1.48857   -10.74267 1.000 23.69029 ? 319 HOH F O      1 
HETATM 2699 O  O      . HOH G 5 .  ? 23.90712  11.93008  5.25848   1.000 28.38846 ? 320 HOH F O      1 
HETATM 2700 O  O      . HOH G 5 .  ? 18.79131  -8.29767  2.31193   1.000 32.59198 ? 321 HOH F O      1 
HETATM 2701 O  O      . HOH G 5 .  ? 1.05008   5.92376   11.81116  1.000 17.38607 ? 322 HOH F O      1 
HETATM 2702 O  O      . HOH G 5 .  ? 13.66656  -6.60598  -7.11413  1.000 19.96911 ? 323 HOH F O      1 
HETATM 2703 O  O      . HOH G 5 .  ? 5.53098   -6.73429  -3.15133  1.000 26.16473 ? 324 HOH F O      1 
HETATM 2704 O  O      . HOH G 5 .  ? 22.62928  -4.24756  -9.45134  1.000 25.31905 ? 325 HOH F O      1 
HETATM 2705 O  O      . HOH G 5 .  ? 17.08791  7.77397   -9.97478  1.000 43.93733 ? 326 HOH F O      1 
HETATM 2706 O  O      . HOH G 5 .  ? 4.98336   -6.69537  7.79875   1.000 19.73602 ? 327 HOH F O      1 
HETATM 2707 O  O      . HOH G 5 .  ? -1.33678  4.09473   -3.43723  1.000 21.05476 ? 328 HOH F O      1 
HETATM 2708 O  O      . HOH G 5 .  ? 4.51336   -7.47695  5.05885   1.000 27.40828 ? 329 HOH F O      1 
HETATM 2709 O  O      . HOH G 5 .  ? -1.19241  14.19354  0.90281   1.000 21.99062 ? 330 HOH F O      1 
HETATM 2710 O  O      . HOH G 5 .  ? 5.83647   6.72202   12.67196  1.000 18.45480 ? 331 HOH F O      1 
HETATM 2711 O  O      . HOH G 5 .  ? 12.19701  7.38759   -10.89195 1.000 44.52450 ? 332 HOH F O      1 
HETATM 2712 O  O      . HOH G 5 .  ? 23.96551  17.32471  6.03973   1.000 47.73676 ? 333 HOH F O      1 
HETATM 2713 O  O      . HOH G 5 .  ? 6.00604   -0.03677  10.64577  1.000 19.75178 ? 334 HOH F O      1 
HETATM 2714 O  O      . HOH G 5 .  ? 6.97820   -9.38728  2.32450   1.000 31.68561 ? 335 HOH F O      1 
HETATM 2715 O  O      . HOH G 5 .  ? 22.50593  10.14011  -0.55060  1.000 21.57958 ? 336 HOH F O      1 
HETATM 2716 O  O      . HOH G 5 .  ? -0.31664  15.89359  -1.86896  1.000 28.88374 ? 337 HOH F O      1 
HETATM 2717 O  O      . HOH G 5 .  ? 14.82147  0.60663   -9.99220  1.000 25.20323 ? 338 HOH F O      1 
HETATM 2718 O  O      . HOH G 5 .  ? 10.94639  13.07297  -3.95405  1.000 28.13398 ? 339 HOH F O      1 
HETATM 2719 O  O      . HOH G 5 .  ? -3.71018  12.87040  8.63061   1.000 30.47694 ? 340 HOH F O      1 
HETATM 2720 O  O      . HOH G 5 .  ? 12.47078  14.98129  15.31691  1.000 32.19454 ? 341 HOH F O      1 
HETATM 2721 O  O      . HOH G 5 .  ? -3.48294  14.98802  4.74865   1.000 44.72757 ? 342 HOH F O      1 
HETATM 2722 O  O      . HOH G 5 .  ? 20.66936  13.28398  10.43335  1.000 27.44423 ? 343 HOH F O      1 
HETATM 2723 O  O      . HOH G 5 .  ? 19.48101  6.34297   12.40048  1.000 21.66288 ? 344 HOH F O      1 
HETATM 2724 O  O      . HOH G 5 .  ? 4.60146   11.58897  11.18554  1.000 25.65741 ? 345 HOH F O      1 
HETATM 2725 O  O      . HOH G 5 .  ? 0.00564   12.77501  2.86702   1.000 22.81319 ? 346 HOH F O      1 
HETATM 2726 O  O      . HOH G 5 .  ? 11.59872  11.50727  12.72424  1.000 18.55656 ? 347 HOH F O      1 
HETATM 2727 O  O      . HOH G 5 .  ? -1.20441  10.15971  10.18673  1.000 28.08667 ? 348 HOH F O      1 
HETATM 2728 O  O      . HOH G 5 .  ? 13.35197  -9.12458  -6.61514  1.000 35.19400 ? 349 HOH F O      1 
HETATM 2729 O  O      . HOH G 5 .  ? 15.47839  -5.38789  11.68614  1.000 20.17306 ? 350 HOH F O      1 
HETATM 2730 O  O      . HOH G 5 .  ? 19.92872  15.42684  14.39751  1.000 35.45867 ? 351 HOH F O      1 
HETATM 2731 O  O      . HOH G 5 .  ? 6.36618   15.54114  -1.66101  1.000 30.41400 ? 352 HOH F O      1 
HETATM 2732 O  O      . HOH G 5 .  ? 18.28108  16.48000  4.71071   1.000 32.23056 ? 353 HOH F O      1 
HETATM 2733 O  O      . HOH G 5 .  ? 16.60975  -6.67092  -1.32779  1.000 27.49105 ? 354 HOH F O      1 
HETATM 2734 O  O      . HOH G 5 .  ? 14.97741  18.76621  1.27405   1.000 38.77672 ? 355 HOH F O      1 
HETATM 2735 O  O      . HOH G 5 .  ? 32.26897  -3.66114  -4.00616  1.000 47.41352 ? 356 HOH F O      1 
HETATM 2736 O  O      . HOH G 5 .  ? 26.50633  5.19292   6.43834   1.000 28.37143 ? 357 HOH F O      1 
HETATM 2737 O  O      . HOH G 5 .  ? 24.03935  8.60302   1.30619   1.000 17.35387 ? 358 HOH F O      1 
HETATM 2738 O  O      . HOH G 5 .  ? 5.66972   -5.57346  -8.88515  1.000 32.38243 ? 359 HOH F O      1 
HETATM 2739 O  O      . HOH G 5 .  ? 8.56530   2.22114   13.67419  1.000 39.69620 ? 360 HOH F O      1 
HETATM 2740 O  O      . HOH G 5 .  ? 16.07779  -9.50706  -3.31911  1.000 39.12737 ? 361 HOH F O      1 
HETATM 2741 O  O      . HOH G 5 .  ? 10.62027  2.17603   -10.68882 1.000 32.02751 ? 362 HOH F O      1 
HETATM 2742 O  O      . HOH G 5 .  ? 17.89768  -4.38185  -13.39198 1.000 40.34144 ? 363 HOH F O      1 
HETATM 2743 O  O      . HOH G 5 .  ? 23.44183  2.63837   13.07162  1.000 37.02141 ? 364 HOH F O      1 
HETATM 2744 O  O      . HOH G 5 .  ? 17.91494  -8.99699  4.50883   1.000 30.02537 ? 365 HOH F O      1 
HETATM 2745 O  O      . HOH G 5 .  ? 9.79505   -4.49550  -9.09145  1.000 28.44148 ? 366 HOH F O      1 
HETATM 2746 O  O      . HOH G 5 .  ? 22.82158  -7.44604  4.06116   1.000 37.18235 ? 367 HOH F O      1 
HETATM 2747 O  O      . HOH G 5 .  ? 12.38579  10.84478  -4.66235  1.000 20.92564 ? 368 HOH F O      1 
HETATM 2748 O  O      . HOH G 5 .  ? 23.25514  0.04531   9.40762   1.000 26.22183 ? 369 HOH F O      1 
HETATM 2749 O  O      . HOH G 5 .  ? 8.38046   3.76092   -9.80235  1.000 22.41769 ? 370 HOH F O      1 
HETATM 2750 O  O      . HOH G 5 .  ? 15.12009  14.99623  -4.30518  1.000 45.47594 ? 371 HOH F O      1 
HETATM 2751 O  O      . HOH G 5 .  ? 2.27395   13.19219  4.41729   1.000 16.51345 ? 372 HOH F O      1 
HETATM 2752 O  O      . HOH G 5 .  ? 16.26918  3.48386   -11.14463 1.000 24.37142 ? 373 HOH F O      1 
HETATM 2753 O  O      . HOH G 5 .  ? 20.69933  -8.75353  8.29052   1.000 26.29690 ? 374 HOH F O      1 
HETATM 2754 O  O      . HOH G 5 .  ? 31.62172  -7.17761  2.53455   1.000 30.21400 ? 375 HOH F O      1 
HETATM 2755 O  O      . HOH G 5 .  ? 19.61498  -8.87650  -4.84272  1.000 29.65856 ? 376 HOH F O      1 
HETATM 2756 O  O      . HOH G 5 .  ? 5.06870   -2.27586  -1.01994  1.000 30.46581 ? 377 HOH F O      1 
HETATM 2757 O  O      . HOH G 5 .  ? 15.45328  -8.94888  8.56194   1.000 30.21882 ? 378 HOH F O      1 
HETATM 2758 O  O      . HOH G 5 .  ? 12.87643  -1.29480  -10.87444 1.000 35.72193 ? 379 HOH F O      1 
HETATM 2759 O  O      . HOH G 5 .  ? 0.31398   2.76948   11.89088  1.000 17.48858 ? 380 HOH F O      1 
HETATM 2760 O  O      . HOH G 5 .  ? 11.71997  -7.16699  4.83963   1.000 27.74348 ? 381 HOH F O      1 
HETATM 2761 O  O      . HOH G 5 .  ? 18.84991  10.51172  14.44451  1.000 25.71552 ? 382 HOH F O      1 
HETATM 2762 O  O      . HOH G 5 .  ? 26.74744  -4.49621  -6.80561  1.000 32.79067 ? 383 HOH F O      1 
HETATM 2763 O  O      . HOH G 5 .  ? 4.19610   -4.18153  -4.07432  1.000 20.93901 ? 384 HOH F O      1 
HETATM 2764 O  O      . HOH G 5 .  ? 24.96593  2.47885   9.52363   1.000 31.80155 ? 385 HOH F O      1 
HETATM 2765 O  O      . HOH G 5 .  ? 24.32473  12.99250  -4.83136  1.000 47.32309 ? 386 HOH F O      1 
HETATM 2766 O  O      . HOH G 5 .  ? 3.10698   -2.19269  0.02228   1.000 19.08780 ? 387 HOH F O      1 
HETATM 2767 O  O      . HOH G 5 .  ? -6.62042  12.41551  -1.17814  1.000 42.97754 ? 388 HOH F O      1 
HETATM 2768 O  O      . HOH G 5 .  ? 22.25306  -1.44759  14.53420  1.000 30.11397 ? 389 HOH F O      1 
HETATM 2769 O  O      . HOH G 5 .  ? 23.34727  -2.26714  -10.56499 1.000 39.72504 ? 390 HOH F O      1 
HETATM 2770 O  O      . HOH G 5 .  ? 10.92859  10.41742  -6.68526  1.000 36.81073 ? 391 HOH F O      1 
HETATM 2771 O  O      . HOH G 5 .  ? 6.08171   3.24542   -11.43183 1.000 39.95759 ? 392 HOH F O      1 
HETATM 2772 O  O      . HOH G 5 .  ? 14.69003  12.67536  -5.32660  1.000 30.44335 ? 393 HOH F O      1 
HETATM 2773 O  O      . HOH G 5 .  ? 2.64164   2.54582   -8.97752  1.000 34.41577 ? 394 HOH F O      1 
HETATM 2774 O  O      . HOH G 5 .  ? 11.535    18.601    4.184     1.000 31.28735 ? 395 HOH F O      1 
HETATM 2775 O  O      . HOH G 5 .  ? 13.07010  9.35876   17.39334  1.000 38.46483 ? 396 HOH F O      1 
HETATM 2776 O  O      . HOH G 5 .  ? 20.20125  8.78977   13.28364  1.000 39.20510 ? 397 HOH F O      1 
HETATM 2777 O  O      . HOH G 5 .  ? -9.75995  4.95504   5.39581   1.000 36.30684 ? 398 HOH F O      1 
HETATM 2778 O  O      . HOH G 5 .  ? 23.29920  2.17093   -11.55135 1.000 35.92062 ? 399 HOH F O      1 
HETATM 2779 O  O      . HOH G 5 .  ? 13.72899  -3.42967  -10.81308 1.000 40.10261 ? 400 HOH F O      1 
HETATM 2780 O  O      . HOH G 5 .  ? 6.82654   17.01619  2.63143   1.000 35.15684 ? 401 HOH F O      1 
HETATM 2781 O  O      . HOH G 5 .  ? 8.79723   -9.53279  5.00345   1.000 44.20974 ? 402 HOH F O      1 
HETATM 2782 O  O      . HOH G 5 .  ? -5.73738  8.12061   -0.58432  1.000 29.56425 ? 403 HOH F O      1 
HETATM 2783 O  O      . HOH G 5 .  ? 25.706    -5.451    4.249     1.000 33.69045 ? 404 HOH F O      1 
HETATM 2784 O  O      . HOH G 5 .  ? -1.41455  8.07986   -10.89514 1.000 44.57360 ? 405 HOH F O      1 
HETATM 2785 O  O      . HOH G 5 .  ? 19.26859  12.71151  -8.74401  1.000 37.09994 ? 406 HOH F O      1 
HETATM 2786 O  O      . HOH G 5 .  ? 0.09795   -7.01424  1.35422   1.000 44.04547 ? 407 HOH F O      1 
HETATM 2787 O  O      . HOH G 5 .  ? 5.22814   16.06981  -3.97937  1.000 31.98609 ? 408 HOH F O      1 
HETATM 2788 O  O      . HOH G 5 .  ? 23.12198  13.27504  8.91128   1.000 45.80553 ? 409 HOH F O      1 
HETATM 2789 O  O      . HOH G 5 .  ? 19.93732  3.97650   -13.28456 1.000 43.61821 ? 410 HOH F O      1 
HETATM 2790 O  O      . HOH G 5 .  ? 20.66292  -7.92117  -2.55012  1.000 33.78344 ? 411 HOH F O      1 
HETATM 2791 O  O      . HOH G 5 .  ? 23.59763  0.14382   12.34247  1.000 37.62741 ? 412 HOH F O      1 
HETATM 2792 O  O      . HOH G 5 .  ? 24.15355  -4.17012  -7.12450  1.000 35.67274 ? 413 HOH F O      1 
HETATM 2793 O  O      . HOH G 5 .  ? 20.972    -8.275    -10.570   1.000 43.28243 ? 414 HOH F O      1 
HETATM 2794 O  O      . HOH G 5 .  ? 2.83021   17.08290  8.95604   1.000 34.37800 ? 415 HOH F O      1 
HETATM 2795 O  O      . HOH G 5 .  ? 23.23344  -6.19686  -5.22877  1.000 23.94134 ? 416 HOH F O      1 
HETATM 2796 O  O      . HOH G 5 .  ? 18.46280  -7.91860  -0.81003  1.000 37.91727 ? 417 HOH F O      1 
HETATM 2797 O  O      . HOH G 5 .  ? 25.64675  -6.81837  -3.52590  1.000 37.23887 ? 418 HOH F O      1 
HETATM 2798 O  O      . HOH G 5 .  ? 7.48172   5.21909   14.20918  1.000 36.89638 ? 419 HOH F O      1 
HETATM 2799 O  O      . HOH G 5 .  ? 17.87251  3.82213   -13.58122 1.000 53.23773 ? 420 HOH F O      1 
HETATM 2800 O  O      . HOH G 5 .  ? 21.08821  -2.14079  -15.73926 1.000 38.69907 ? 421 HOH F O      1 
HETATM 2801 O  O      . HOH G 5 .  ? 20.121    21.606    6.590     1.000 38.94518 ? 422 HOH F O      1 
HETATM 2802 O  O      . HOH G 5 .  ? 22.77334  1.56860   -14.12372 1.000 34.26751 ? 423 HOH F O      1 
HETATM 2803 O  O      . HOH G 5 .  ? 20.77519  -8.90923  5.41918   1.000 33.65166 ? 424 HOH F O      1 
HETATM 2804 O  O      . HOH G 5 .  ? 1.50204   -6.15906  -1.34616  1.000 32.76311 ? 425 HOH F O      1 
HETATM 2805 O  O      . HOH G 5 .  ? 15.46079  17.96374  4.40014   1.000 42.50076 ? 426 HOH F O      1 
HETATM 2806 O  O      . HOH G 5 .  ? 25.17250  -7.70834  3.23218   1.000 45.27604 ? 427 HOH F O      1 
HETATM 2807 O  O      . HOH G 5 .  ? -1.20125  7.81212   11.49987  1.000 28.08829 ? 428 HOH F O      1 
HETATM 2808 O  O      . HOH G 5 .  ? -6.41577  13.69170  8.17042   1.000 40.95034 ? 429 HOH F O      1 
HETATM 2809 O  O      . HOH G 5 .  ? 15.13513  12.94444  -8.14339  1.000 42.42854 ? 430 HOH F O      1 
HETATM 2810 O  O      . HOH G 5 .  ? 9.50169   0.23349   11.66829  1.000 28.09301 ? 431 HOH F O      1 
HETATM 2811 O  O      . HOH G 5 .  ? -1.11848  15.81278  4.64424   1.000 47.32108 ? 432 HOH F O      1 
HETATM 2812 O  O      . HOH G 5 .  ? 15.35542  3.68924   -13.44155 1.000 47.70291 ? 433 HOH F O      1 
HETATM 2813 O  O      . HOH G 5 .  ? 29.01720  2.11244   8.01061   1.000 31.90834 ? 434 HOH F O      1 
HETATM 2814 O  O      . HOH G 5 .  ? 25.40852  14.20576  5.44277   1.000 43.22077 ? 435 HOH F O      1 
HETATM 2815 O  O      . HOH G 5 .  ? 20.46077  12.82947  14.73612  1.000 45.01568 ? 436 HOH F O      1 
HETATM 2816 O  O      . HOH G 5 .  ? 14.83649  0.62275   -13.17895 1.000 44.72916 ? 437 HOH F O      1 
HETATM 2817 O  O      . HOH G 5 .  ? 12.48587  -5.67228  -9.51207  1.000 34.66527 ? 438 HOH F O      1 
HETATM 2818 O  O      . HOH G 5 .  ? 20.91627  -4.48490  -14.25680 1.000 47.00307 ? 439 HOH F O      1 
HETATM 2819 O  O      . HOH G 5 .  ? 26.75445  7.68421   0.29686   1.000 30.69414 ? 440 HOH F O      1 
HETATM 2820 O  O      . HOH G 5 .  ? 1.69908   15.52488  5.70985   1.000 37.85889 ? 441 HOH F O      1 
HETATM 2821 O  O      . HOH G 5 .  ? 6.70409   17.76034  0.54400   1.000 32.34572 ? 442 HOH F O      1 
HETATM 2822 O  O      . HOH G 5 .  ? 17.12089  19.79586  4.95333   1.000 48.76211 ? 443 HOH F O      1 
HETATM 2823 O  O      . HOH G 5 .  ? 9.59912   6.14926   -11.36383 1.000 52.14471 ? 444 HOH F O      1 
# 
