data_9CHX
# 
_entry.id   9CHX 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9CHX         pdb_00009chx 10.2210/pdb9chx/pdb 
WWPDB D_1000285547 ?            ?                   
EMDB  EMD-45604    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2024-11-13 
2 'Structure model' 1 1 2024-11-27 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Data collection'     
2 2 'Structure model' 'Database references' 
3 2 'Structure model' 'Structure summary'   
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' audit_author        
2 2 'Structure model' citation            
3 2 'Structure model' citation_author     
4 2 'Structure model' em_admin            
5 2 'Structure model' em_author_list      
6 2 'Structure model' pdbx_contact_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_audit_author.name'                    
2  2 'Structure model' '_citation.country'                     
3  2 'Structure model' '_citation.journal_abbrev'              
4  2 'Structure model' '_citation.journal_id_ASTM'             
5  2 'Structure model' '_citation.journal_id_CSD'              
6  2 'Structure model' '_citation.journal_id_ISSN'             
7  2 'Structure model' '_citation.journal_volume'              
8  2 'Structure model' '_citation.page_first'                  
9  2 'Structure model' '_citation.page_last'                   
10 2 'Structure model' '_citation.pdbx_database_id_DOI'        
11 2 'Structure model' '_citation.pdbx_database_id_PubMed'     
12 2 'Structure model' '_citation.title'                       
13 2 'Structure model' '_citation.year'                        
14 2 'Structure model' '_em_admin.last_update'                 
15 2 'Structure model' '_em_author_list.author'                
16 2 'Structure model' '_pdbx_contact_author.email'            
17 2 'Structure model' '_pdbx_contact_author.identifier_ORCID' 
18 2 'Structure model' '_pdbx_contact_author.name_first'       
19 2 'Structure model' '_pdbx_contact_author.name_last'        
20 2 'Structure model' '_pdbx_contact_author.phone'            
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9CHX 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-02 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        
'cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state' 
_pdbx_database_related.db_id          EMD-45604 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              kobilka@stanford.edu 
_pdbx_contact_author.name_first         Brian 
_pdbx_contact_author.name_last          Kobilka 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-5958-3990 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Xu, J.'        1 ? 
'Chen, G.'      2 ? 
'Du, Y.'        3 ? 
'Kobilka, B.K.' 4 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Proc.Natl.Acad.Sci.USA 
_citation.journal_id_ASTM           PNASA6 
_citation.journal_id_CSD            0040 
_citation.journal_id_ISSN           1091-6490 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            121 
_citation.language                  ? 
_citation.page_first                e2414544121 
_citation.page_last                 e2414544121 
_citation.title                     'Calcineurin-fusion facilitates cryo-EM structure determination of a Family A GPCR.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1073/pnas.2414544121 
_citation.pdbx_database_id_PubMed   39565314 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Xu, J.'        1 ?                   
primary 'Chen, G.'      2 ?                   
primary 'Wang, H.'      3 ?                   
primary 'Cao, S.'       4 ?                   
primary 'Heng, J.'      5 ?                   
primary 'Deupi, X.'     6 ?                   
primary 'Du, Y.'        7 0000-0001-8107-6397 
primary 'Kobilka, B.K.' 8 0000-0001-5958-3990 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Beta-2 adrenergic receptor,Calcineurin subunit B type 1'    51309.711 1 ?        ? ?                
;residues 29-354 (Uniprot numbering) of the beta2-AR with the third cytoplasmic domain replaced with residues 16-170 (Uniprot numbering) of calcineurin subunit B
;
2 polymer     man 'Protein phosphatase 3 catalytic subunit alpha'              42627.785 1 3.1.3.16 ? 'residues 1-370' ? 
3 polymer     man 'Peptidyl-prolyl cis-trans isomerase FKBP1A'                 11967.705 1 5.2.1.8  ? ?                ? 
4 non-polymer syn '(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol' 298.379   1 ?        ? ?                ? 
5 non-polymer syn '8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN'                         804.018   1 ?        ? ?                ? 
# 
loop_
_entity_name_com.entity_id 
_entity_name_com.name 
2 
;CAM-PRP catalytic subunit,Calcineurin A alpha,Calmodulin-dependent calcineurin A subunit alpha isoform,CNA alpha,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
;
3 'PPIase FKBP1A,12 kDa FK506-binding protein,FKBP-12,Calstabin-1,FK506-binding protein 1A,FKBP-1A,Immunophilin FKBP12,Rotamase' 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEF
WTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEE
TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNP
LVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIV
DKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDVKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRK
EVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRDDLKAYGNGY
;
;DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEF
WTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEE
TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNP
LVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIV
DKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDVKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRK
EVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRDDLKAYGNGY
;
A ? 
2 'polypeptide(L)' no no 
;SEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDI
DAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFT
FKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGN
EKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAV
LKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNI
;
;SEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDI
DAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFT
FKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGN
EKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAV
LKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNI
;
B ? 
3 'polypeptide(L)' no no 
;MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPD
YAYGATGHPGIIPPHATLVFDVELLKLE
;
;MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPD
YAYGATGHPGIIPPHATLVFDVELLKLE
;
C ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
4 '(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol' CAU 
5 '8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN'                         FK5 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   ASP n 
1 2   GLU n 
1 3   VAL n 
1 4   TRP n 
1 5   VAL n 
1 6   VAL n 
1 7   GLY n 
1 8   MET n 
1 9   GLY n 
1 10  ILE n 
1 11  VAL n 
1 12  MET n 
1 13  SER n 
1 14  LEU n 
1 15  ILE n 
1 16  VAL n 
1 17  LEU n 
1 18  ALA n 
1 19  ILE n 
1 20  VAL n 
1 21  PHE n 
1 22  GLY n 
1 23  ASN n 
1 24  VAL n 
1 25  LEU n 
1 26  VAL n 
1 27  ILE n 
1 28  THR n 
1 29  ALA n 
1 30  ILE n 
1 31  ALA n 
1 32  LYS n 
1 33  PHE n 
1 34  GLU n 
1 35  ARG n 
1 36  LEU n 
1 37  GLN n 
1 38  THR n 
1 39  VAL n 
1 40  THR n 
1 41  ASN n 
1 42  TYR n 
1 43  PHE n 
1 44  ILE n 
1 45  THR n 
1 46  SER n 
1 47  LEU n 
1 48  ALA n 
1 49  CYS n 
1 50  ALA n 
1 51  ASP n 
1 52  LEU n 
1 53  VAL n 
1 54  MET n 
1 55  GLY n 
1 56  LEU n 
1 57  ALA n 
1 58  VAL n 
1 59  VAL n 
1 60  PRO n 
1 61  PHE n 
1 62  GLY n 
1 63  ALA n 
1 64  ALA n 
1 65  HIS n 
1 66  ILE n 
1 67  LEU n 
1 68  MET n 
1 69  LYS n 
1 70  MET n 
1 71  TRP n 
1 72  THR n 
1 73  PHE n 
1 74  GLY n 
1 75  ASN n 
1 76  PHE n 
1 77  TRP n 
1 78  CYS n 
1 79  GLU n 
1 80  PHE n 
1 81  TRP n 
1 82  THR n 
1 83  SER n 
1 84  ILE n 
1 85  ASP n 
1 86  VAL n 
1 87  LEU n 
1 88  CYS n 
1 89  VAL n 
1 90  THR n 
1 91  ALA n 
1 92  SER n 
1 93  ILE n 
1 94  GLU n 
1 95  THR n 
1 96  LEU n 
1 97  CYS n 
1 98  VAL n 
1 99  ILE n 
1 100 ALA n 
1 101 VAL n 
1 102 ASP n 
1 103 ARG n 
1 104 TYR n 
1 105 PHE n 
1 106 ALA n 
1 107 ILE n 
1 108 THR n 
1 109 SER n 
1 110 PRO n 
1 111 PHE n 
1 112 LYS n 
1 113 TYR n 
1 114 GLN n 
1 115 SER n 
1 116 LEU n 
1 117 LEU n 
1 118 THR n 
1 119 LYS n 
1 120 ASN n 
1 121 LYS n 
1 122 ALA n 
1 123 ARG n 
1 124 VAL n 
1 125 ILE n 
1 126 ILE n 
1 127 LEU n 
1 128 MET n 
1 129 VAL n 
1 130 TRP n 
1 131 ILE n 
1 132 VAL n 
1 133 SER n 
1 134 GLY n 
1 135 LEU n 
1 136 THR n 
1 137 SER n 
1 138 PHE n 
1 139 LEU n 
1 140 PRO n 
1 141 ILE n 
1 142 GLN n 
1 143 MET n 
1 144 HIS n 
1 145 TRP n 
1 146 TYR n 
1 147 ARG n 
1 148 ALA n 
1 149 THR n 
1 150 HIS n 
1 151 GLN n 
1 152 GLU n 
1 153 ALA n 
1 154 ILE n 
1 155 ASN n 
1 156 CYS n 
1 157 TYR n 
1 158 ALA n 
1 159 GLU n 
1 160 GLU n 
1 161 THR n 
1 162 CYS n 
1 163 CYS n 
1 164 ASP n 
1 165 PHE n 
1 166 PHE n 
1 167 THR n 
1 168 ASN n 
1 169 GLN n 
1 170 ALA n 
1 171 TYR n 
1 172 ALA n 
1 173 ILE n 
1 174 ALA n 
1 175 SER n 
1 176 SER n 
1 177 ILE n 
1 178 VAL n 
1 179 SER n 
1 180 PHE n 
1 181 TYR n 
1 182 VAL n 
1 183 PRO n 
1 184 LEU n 
1 185 VAL n 
1 186 ILE n 
1 187 MET n 
1 188 VAL n 
1 189 PHE n 
1 190 VAL n 
1 191 TYR n 
1 192 SER n 
1 193 ARG n 
1 194 VAL n 
1 195 PHE n 
1 196 GLN n 
1 197 GLU n 
1 198 ALA n 
1 199 LYS n 
1 200 ARG n 
1 201 GLN n 
1 202 LEU n 
1 203 ASP n 
1 204 ALA n 
1 205 ASP n 
1 206 GLU n 
1 207 ILE n 
1 208 LYS n 
1 209 ARG n 
1 210 LEU n 
1 211 GLY n 
1 212 LYS n 
1 213 ARG n 
1 214 PHE n 
1 215 LYS n 
1 216 LYS n 
1 217 LEU n 
1 218 ASP n 
1 219 LEU n 
1 220 ASP n 
1 221 ASN n 
1 222 SER n 
1 223 GLY n 
1 224 SER n 
1 225 LEU n 
1 226 SER n 
1 227 VAL n 
1 228 GLU n 
1 229 GLU n 
1 230 PHE n 
1 231 MET n 
1 232 SER n 
1 233 LEU n 
1 234 PRO n 
1 235 GLU n 
1 236 LEU n 
1 237 GLN n 
1 238 GLN n 
1 239 ASN n 
1 240 PRO n 
1 241 LEU n 
1 242 VAL n 
1 243 GLN n 
1 244 ARG n 
1 245 VAL n 
1 246 ILE n 
1 247 ASP n 
1 248 ILE n 
1 249 PHE n 
1 250 ASP n 
1 251 THR n 
1 252 ASP n 
1 253 GLY n 
1 254 ASN n 
1 255 GLY n 
1 256 GLU n 
1 257 VAL n 
1 258 ASP n 
1 259 PHE n 
1 260 LYS n 
1 261 GLU n 
1 262 PHE n 
1 263 ILE n 
1 264 GLU n 
1 265 GLY n 
1 266 VAL n 
1 267 SER n 
1 268 GLN n 
1 269 PHE n 
1 270 SER n 
1 271 VAL n 
1 272 LYS n 
1 273 GLY n 
1 274 ASP n 
1 275 LYS n 
1 276 GLU n 
1 277 GLN n 
1 278 LYS n 
1 279 LEU n 
1 280 ARG n 
1 281 PHE n 
1 282 ALA n 
1 283 PHE n 
1 284 ARG n 
1 285 ILE n 
1 286 TYR n 
1 287 ASP n 
1 288 MET n 
1 289 ASP n 
1 290 LYS n 
1 291 ASP n 
1 292 GLY n 
1 293 TYR n 
1 294 ILE n 
1 295 SER n 
1 296 ASN n 
1 297 GLY n 
1 298 GLU n 
1 299 LEU n 
1 300 PHE n 
1 301 GLN n 
1 302 VAL n 
1 303 LEU n 
1 304 LYS n 
1 305 MET n 
1 306 MET n 
1 307 VAL n 
1 308 GLY n 
1 309 ASN n 
1 310 ASN n 
1 311 LEU n 
1 312 LYS n 
1 313 ASP n 
1 314 THR n 
1 315 GLN n 
1 316 LEU n 
1 317 GLN n 
1 318 GLN n 
1 319 ILE n 
1 320 VAL n 
1 321 ASP n 
1 322 LYS n 
1 323 THR n 
1 324 ILE n 
1 325 ILE n 
1 326 ASN n 
1 327 ALA n 
1 328 ASP n 
1 329 LYS n 
1 330 ASP n 
1 331 GLY n 
1 332 ASP n 
1 333 GLY n 
1 334 ARG n 
1 335 ILE n 
1 336 SER n 
1 337 PHE n 
1 338 GLU n 
1 339 GLU n 
1 340 PHE n 
1 341 CYS n 
1 342 ALA n 
1 343 VAL n 
1 344 VAL n 
1 345 GLY n 
1 346 GLY n 
1 347 LEU n 
1 348 ASP n 
1 349 ILE n 
1 350 HIS n 
1 351 LYS n 
1 352 LYS n 
1 353 MET n 
1 354 VAL n 
1 355 VAL n 
1 356 ASP n 
1 357 VAL n 
1 358 LYS n 
1 359 PHE n 
1 360 CYS n 
1 361 LEU n 
1 362 LYS n 
1 363 GLU n 
1 364 HIS n 
1 365 LYS n 
1 366 ALA n 
1 367 LEU n 
1 368 LYS n 
1 369 THR n 
1 370 LEU n 
1 371 GLY n 
1 372 ILE n 
1 373 ILE n 
1 374 MET n 
1 375 GLY n 
1 376 THR n 
1 377 PHE n 
1 378 THR n 
1 379 LEU n 
1 380 CYS n 
1 381 TRP n 
1 382 LEU n 
1 383 PRO n 
1 384 PHE n 
1 385 PHE n 
1 386 ILE n 
1 387 VAL n 
1 388 ASN n 
1 389 ILE n 
1 390 VAL n 
1 391 HIS n 
1 392 VAL n 
1 393 ILE n 
1 394 GLN n 
1 395 ASP n 
1 396 ASN n 
1 397 LEU n 
1 398 ILE n 
1 399 ARG n 
1 400 LYS n 
1 401 GLU n 
1 402 VAL n 
1 403 TYR n 
1 404 ILE n 
1 405 LEU n 
1 406 LEU n 
1 407 ASN n 
1 408 TRP n 
1 409 ILE n 
1 410 GLY n 
1 411 TYR n 
1 412 VAL n 
1 413 ASN n 
1 414 SER n 
1 415 GLY n 
1 416 PHE n 
1 417 ASN n 
1 418 PRO n 
1 419 LEU n 
1 420 ILE n 
1 421 TYR n 
1 422 CYS n 
1 423 ARG n 
1 424 SER n 
1 425 PRO n 
1 426 ASP n 
1 427 PHE n 
1 428 ARG n 
1 429 ILE n 
1 430 ALA n 
1 431 PHE n 
1 432 GLN n 
1 433 GLU n 
1 434 LEU n 
1 435 LEU n 
1 436 CYS n 
1 437 LEU n 
1 438 ARG n 
1 439 ARG n 
1 440 ASP n 
1 441 ASP n 
1 442 LEU n 
1 443 LYS n 
1 444 ALA n 
1 445 TYR n 
1 446 GLY n 
1 447 ASN n 
1 448 GLY n 
1 449 TYR n 
2 1   SER n 
2 2   GLU n 
2 3   PRO n 
2 4   LYS n 
2 5   ALA n 
2 6   ILE n 
2 7   ASP n 
2 8   PRO n 
2 9   LYS n 
2 10  LEU n 
2 11  SER n 
2 12  THR n 
2 13  THR n 
2 14  ASP n 
2 15  ARG n 
2 16  VAL n 
2 17  VAL n 
2 18  LYS n 
2 19  ALA n 
2 20  VAL n 
2 21  PRO n 
2 22  PHE n 
2 23  PRO n 
2 24  PRO n 
2 25  SER n 
2 26  HIS n 
2 27  ARG n 
2 28  LEU n 
2 29  THR n 
2 30  ALA n 
2 31  LYS n 
2 32  GLU n 
2 33  VAL n 
2 34  PHE n 
2 35  ASP n 
2 36  ASN n 
2 37  ASP n 
2 38  GLY n 
2 39  LYS n 
2 40  PRO n 
2 41  ARG n 
2 42  VAL n 
2 43  ASP n 
2 44  ILE n 
2 45  LEU n 
2 46  LYS n 
2 47  ALA n 
2 48  HIS n 
2 49  LEU n 
2 50  MET n 
2 51  LYS n 
2 52  GLU n 
2 53  GLY n 
2 54  ARG n 
2 55  LEU n 
2 56  GLU n 
2 57  GLU n 
2 58  SER n 
2 59  VAL n 
2 60  ALA n 
2 61  LEU n 
2 62  ARG n 
2 63  ILE n 
2 64  ILE n 
2 65  THR n 
2 66  GLU n 
2 67  GLY n 
2 68  ALA n 
2 69  SER n 
2 70  ILE n 
2 71  LEU n 
2 72  ARG n 
2 73  GLN n 
2 74  GLU n 
2 75  LYS n 
2 76  ASN n 
2 77  LEU n 
2 78  LEU n 
2 79  ASP n 
2 80  ILE n 
2 81  ASP n 
2 82  ALA n 
2 83  PRO n 
2 84  VAL n 
2 85  THR n 
2 86  VAL n 
2 87  CYS n 
2 88  GLY n 
2 89  ASP n 
2 90  ILE n 
2 91  HIS n 
2 92  GLY n 
2 93  GLN n 
2 94  PHE n 
2 95  PHE n 
2 96  ASP n 
2 97  LEU n 
2 98  MET n 
2 99  LYS n 
2 100 LEU n 
2 101 PHE n 
2 102 GLU n 
2 103 VAL n 
2 104 GLY n 
2 105 GLY n 
2 106 SER n 
2 107 PRO n 
2 108 ALA n 
2 109 ASN n 
2 110 THR n 
2 111 ARG n 
2 112 TYR n 
2 113 LEU n 
2 114 PHE n 
2 115 LEU n 
2 116 GLY n 
2 117 ASP n 
2 118 TYR n 
2 119 VAL n 
2 120 ASP n 
2 121 ARG n 
2 122 GLY n 
2 123 TYR n 
2 124 PHE n 
2 125 SER n 
2 126 ILE n 
2 127 GLU n 
2 128 CYS n 
2 129 VAL n 
2 130 LEU n 
2 131 TYR n 
2 132 LEU n 
2 133 TRP n 
2 134 ALA n 
2 135 LEU n 
2 136 LYS n 
2 137 ILE n 
2 138 LEU n 
2 139 TYR n 
2 140 PRO n 
2 141 LYS n 
2 142 THR n 
2 143 LEU n 
2 144 PHE n 
2 145 LEU n 
2 146 LEU n 
2 147 ARG n 
2 148 GLY n 
2 149 ASN n 
2 150 HIS n 
2 151 GLU n 
2 152 CYS n 
2 153 ARG n 
2 154 HIS n 
2 155 LEU n 
2 156 THR n 
2 157 GLU n 
2 158 TYR n 
2 159 PHE n 
2 160 THR n 
2 161 PHE n 
2 162 LYS n 
2 163 GLN n 
2 164 GLU n 
2 165 CYS n 
2 166 LYS n 
2 167 ILE n 
2 168 LYS n 
2 169 TYR n 
2 170 SER n 
2 171 GLU n 
2 172 ARG n 
2 173 VAL n 
2 174 TYR n 
2 175 ASP n 
2 176 ALA n 
2 177 CYS n 
2 178 MET n 
2 179 ASP n 
2 180 ALA n 
2 181 PHE n 
2 182 ASP n 
2 183 CYS n 
2 184 LEU n 
2 185 PRO n 
2 186 LEU n 
2 187 ALA n 
2 188 ALA n 
2 189 LEU n 
2 190 MET n 
2 191 ASN n 
2 192 GLN n 
2 193 GLN n 
2 194 PHE n 
2 195 LEU n 
2 196 CYS n 
2 197 VAL n 
2 198 HIS n 
2 199 GLY n 
2 200 GLY n 
2 201 LEU n 
2 202 SER n 
2 203 PRO n 
2 204 GLU n 
2 205 ILE n 
2 206 ASN n 
2 207 THR n 
2 208 LEU n 
2 209 ASP n 
2 210 ASP n 
2 211 ILE n 
2 212 ARG n 
2 213 LYS n 
2 214 LEU n 
2 215 ASP n 
2 216 ARG n 
2 217 PHE n 
2 218 LYS n 
2 219 GLU n 
2 220 PRO n 
2 221 PRO n 
2 222 ALA n 
2 223 TYR n 
2 224 GLY n 
2 225 PRO n 
2 226 MET n 
2 227 CYS n 
2 228 ASP n 
2 229 ILE n 
2 230 LEU n 
2 231 TRP n 
2 232 SER n 
2 233 ASP n 
2 234 PRO n 
2 235 LEU n 
2 236 GLU n 
2 237 ASP n 
2 238 PHE n 
2 239 GLY n 
2 240 ASN n 
2 241 GLU n 
2 242 LYS n 
2 243 THR n 
2 244 GLN n 
2 245 GLU n 
2 246 HIS n 
2 247 PHE n 
2 248 THR n 
2 249 HIS n 
2 250 ASN n 
2 251 THR n 
2 252 VAL n 
2 253 ARG n 
2 254 GLY n 
2 255 CYS n 
2 256 SER n 
2 257 TYR n 
2 258 PHE n 
2 259 TYR n 
2 260 SER n 
2 261 TYR n 
2 262 PRO n 
2 263 ALA n 
2 264 VAL n 
2 265 CYS n 
2 266 ASP n 
2 267 PHE n 
2 268 LEU n 
2 269 GLN n 
2 270 HIS n 
2 271 ASN n 
2 272 ASN n 
2 273 LEU n 
2 274 LEU n 
2 275 SER n 
2 276 ILE n 
2 277 LEU n 
2 278 ARG n 
2 279 ALA n 
2 280 HIS n 
2 281 GLU n 
2 282 ALA n 
2 283 GLN n 
2 284 ASP n 
2 285 ALA n 
2 286 GLY n 
2 287 TYR n 
2 288 ARG n 
2 289 MET n 
2 290 TYR n 
2 291 ARG n 
2 292 LYS n 
2 293 SER n 
2 294 GLN n 
2 295 THR n 
2 296 THR n 
2 297 GLY n 
2 298 PHE n 
2 299 PRO n 
2 300 SER n 
2 301 LEU n 
2 302 ILE n 
2 303 THR n 
2 304 ILE n 
2 305 PHE n 
2 306 SER n 
2 307 ALA n 
2 308 PRO n 
2 309 ASN n 
2 310 TYR n 
2 311 LEU n 
2 312 ASP n 
2 313 VAL n 
2 314 TYR n 
2 315 ASN n 
2 316 ASN n 
2 317 LYS n 
2 318 ALA n 
2 319 ALA n 
2 320 VAL n 
2 321 LEU n 
2 322 LYS n 
2 323 TYR n 
2 324 GLU n 
2 325 ASN n 
2 326 ASN n 
2 327 VAL n 
2 328 MET n 
2 329 ASN n 
2 330 ILE n 
2 331 ARG n 
2 332 GLN n 
2 333 PHE n 
2 334 ASN n 
2 335 CYS n 
2 336 SER n 
2 337 PRO n 
2 338 HIS n 
2 339 PRO n 
2 340 TYR n 
2 341 TRP n 
2 342 LEU n 
2 343 PRO n 
2 344 ASN n 
2 345 PHE n 
2 346 MET n 
2 347 ASP n 
2 348 VAL n 
2 349 PHE n 
2 350 THR n 
2 351 TRP n 
2 352 SER n 
2 353 LEU n 
2 354 PRO n 
2 355 PHE n 
2 356 VAL n 
2 357 GLY n 
2 358 GLU n 
2 359 LYS n 
2 360 VAL n 
2 361 THR n 
2 362 GLU n 
2 363 MET n 
2 364 LEU n 
2 365 VAL n 
2 366 ASN n 
2 367 VAL n 
2 368 LEU n 
2 369 ASN n 
2 370 ILE n 
3 1   MET n 
3 2   GLY n 
3 3   VAL n 
3 4   GLN n 
3 5   VAL n 
3 6   GLU n 
3 7   THR n 
3 8   ILE n 
3 9   SER n 
3 10  PRO n 
3 11  GLY n 
3 12  ASP n 
3 13  GLY n 
3 14  ARG n 
3 15  THR n 
3 16  PHE n 
3 17  PRO n 
3 18  LYS n 
3 19  ARG n 
3 20  GLY n 
3 21  GLN n 
3 22  THR n 
3 23  CYS n 
3 24  VAL n 
3 25  VAL n 
3 26  HIS n 
3 27  TYR n 
3 28  THR n 
3 29  GLY n 
3 30  MET n 
3 31  LEU n 
3 32  GLU n 
3 33  ASP n 
3 34  GLY n 
3 35  LYS n 
3 36  LYS n 
3 37  PHE n 
3 38  ASP n 
3 39  SER n 
3 40  SER n 
3 41  ARG n 
3 42  ASP n 
3 43  ARG n 
3 44  ASN n 
3 45  LYS n 
3 46  PRO n 
3 47  PHE n 
3 48  LYS n 
3 49  PHE n 
3 50  MET n 
3 51  LEU n 
3 52  GLY n 
3 53  LYS n 
3 54  GLN n 
3 55  GLU n 
3 56  VAL n 
3 57  ILE n 
3 58  ARG n 
3 59  GLY n 
3 60  TRP n 
3 61  GLU n 
3 62  GLU n 
3 63  GLY n 
3 64  VAL n 
3 65  ALA n 
3 66  GLN n 
3 67  MET n 
3 68  SER n 
3 69  VAL n 
3 70  GLY n 
3 71  GLN n 
3 72  ARG n 
3 73  ALA n 
3 74  LYS n 
3 75  LEU n 
3 76  THR n 
3 77  ILE n 
3 78  SER n 
3 79  PRO n 
3 80  ASP n 
3 81  TYR n 
3 82  ALA n 
3 83  TYR n 
3 84  GLY n 
3 85  ALA n 
3 86  THR n 
3 87  GLY n 
3 88  HIS n 
3 89  PRO n 
3 90  GLY n 
3 91  ILE n 
3 92  ILE n 
3 93  PRO n 
3 94  PRO n 
3 95  HIS n 
3 96  ALA n 
3 97  THR n 
3 98  LEU n 
3 99  VAL n 
3 100 PHE n 
3 101 ASP n 
3 102 VAL n 
3 103 GLU n 
3 104 LEU n 
3 105 LEU n 
3 106 LYS n 
3 107 LEU n 
3 108 GLU n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   202 human         ? 'ADRB2, ADRB2R, B2AR'   ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? ? 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 203 357 human         ? 'PPP3R1, CNA2, CNB'     ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? ? 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 3 sample 'Biological sequence' 358 449 human         ? 'ADRB2, ADRB2R, B2AR'   ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? ? 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1   370 'house mouse' ? 'Ppp3ca, Calna'         ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? ? 
'Spodoptera frugiperda' 7108 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1   108 human         ? 'FKBP1A, FKBP1, FKBP12' ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? ? 
'Escherichia coli'      562  ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                      ?               'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                     ?               'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                   ?               'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                              ?               'C4 H7 N O4'     133.103 
CAU non-polymer         . '(2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol' '(S)-Carazolol' 'C18 H22 N2 O2'  298.379 
CYS 'L-peptide linking' y CYSTEINE                                                     ?               'C3 H7 N O2 S'   121.158 
FK5 non-polymer         . '8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN'                         K506            'C44 H69 N O12'  804.018 
GLN 'L-peptide linking' y GLUTAMINE                                                    ?               'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                              ?               'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                      ?               'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                    ?               'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE                                                   ?               'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                      ?               'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                       ?               'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE                                                   ?               'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE                                                ?               'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE                                                      ?               'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                       ?               'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                    ?               'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                   ?               'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                     ?               'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                       ?               'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   ASP 1   29  ?   ?   ?   A . n 
A 1 2   GLU 2   30  ?   ?   ?   A . n 
A 1 3   VAL 3   31  ?   ?   ?   A . n 
A 1 4   TRP 4   32  32  TRP TRP A . n 
A 1 5   VAL 5   33  33  VAL VAL A . n 
A 1 6   VAL 6   34  34  VAL VAL A . n 
A 1 7   GLY 7   35  35  GLY GLY A . n 
A 1 8   MET 8   36  36  MET MET A . n 
A 1 9   GLY 9   37  37  GLY GLY A . n 
A 1 10  ILE 10  38  38  ILE ILE A . n 
A 1 11  VAL 11  39  39  VAL VAL A . n 
A 1 12  MET 12  40  40  MET MET A . n 
A 1 13  SER 13  41  41  SER SER A . n 
A 1 14  LEU 14  42  42  LEU LEU A . n 
A 1 15  ILE 15  43  43  ILE ILE A . n 
A 1 16  VAL 16  44  44  VAL VAL A . n 
A 1 17  LEU 17  45  45  LEU LEU A . n 
A 1 18  ALA 18  46  46  ALA ALA A . n 
A 1 19  ILE 19  47  47  ILE ILE A . n 
A 1 20  VAL 20  48  48  VAL VAL A . n 
A 1 21  PHE 21  49  49  PHE PHE A . n 
A 1 22  GLY 22  50  50  GLY GLY A . n 
A 1 23  ASN 23  51  51  ASN ASN A . n 
A 1 24  VAL 24  52  52  VAL VAL A . n 
A 1 25  LEU 25  53  53  LEU LEU A . n 
A 1 26  VAL 26  54  54  VAL VAL A . n 
A 1 27  ILE 27  55  55  ILE ILE A . n 
A 1 28  THR 28  56  56  THR THR A . n 
A 1 29  ALA 29  57  57  ALA ALA A . n 
A 1 30  ILE 30  58  58  ILE ILE A . n 
A 1 31  ALA 31  59  59  ALA ALA A . n 
A 1 32  LYS 32  60  60  LYS LYS A . n 
A 1 33  PHE 33  61  61  PHE PHE A . n 
A 1 34  GLU 34  62  62  GLU GLU A . n 
A 1 35  ARG 35  63  63  ARG ARG A . n 
A 1 36  LEU 36  64  64  LEU LEU A . n 
A 1 37  GLN 37  65  65  GLN GLN A . n 
A 1 38  THR 38  66  66  THR THR A . n 
A 1 39  VAL 39  67  67  VAL VAL A . n 
A 1 40  THR 40  68  68  THR THR A . n 
A 1 41  ASN 41  69  69  ASN ASN A . n 
A 1 42  TYR 42  70  70  TYR TYR A . n 
A 1 43  PHE 43  71  71  PHE PHE A . n 
A 1 44  ILE 44  72  72  ILE ILE A . n 
A 1 45  THR 45  73  73  THR THR A . n 
A 1 46  SER 46  74  74  SER SER A . n 
A 1 47  LEU 47  75  75  LEU LEU A . n 
A 1 48  ALA 48  76  76  ALA ALA A . n 
A 1 49  CYS 49  77  77  CYS CYS A . n 
A 1 50  ALA 50  78  78  ALA ALA A . n 
A 1 51  ASP 51  79  79  ASP ASP A . n 
A 1 52  LEU 52  80  80  LEU LEU A . n 
A 1 53  VAL 53  81  81  VAL VAL A . n 
A 1 54  MET 54  82  82  MET MET A . n 
A 1 55  GLY 55  83  83  GLY GLY A . n 
A 1 56  LEU 56  84  84  LEU LEU A . n 
A 1 57  ALA 57  85  85  ALA ALA A . n 
A 1 58  VAL 58  86  86  VAL VAL A . n 
A 1 59  VAL 59  87  87  VAL VAL A . n 
A 1 60  PRO 60  88  88  PRO PRO A . n 
A 1 61  PHE 61  89  89  PHE PHE A . n 
A 1 62  GLY 62  90  90  GLY GLY A . n 
A 1 63  ALA 63  91  91  ALA ALA A . n 
A 1 64  ALA 64  92  92  ALA ALA A . n 
A 1 65  HIS 65  93  93  HIS HIS A . n 
A 1 66  ILE 66  94  94  ILE ILE A . n 
A 1 67  LEU 67  95  95  LEU LEU A . n 
A 1 68  MET 68  96  96  MET MET A . n 
A 1 69  LYS 69  97  97  LYS LYS A . n 
A 1 70  MET 70  98  98  MET MET A . n 
A 1 71  TRP 71  99  99  TRP TRP A . n 
A 1 72  THR 72  100 100 THR THR A . n 
A 1 73  PHE 73  101 101 PHE PHE A . n 
A 1 74  GLY 74  102 102 GLY GLY A . n 
A 1 75  ASN 75  103 103 ASN ASN A . n 
A 1 76  PHE 76  104 104 PHE PHE A . n 
A 1 77  TRP 77  105 105 TRP TRP A . n 
A 1 78  CYS 78  106 106 CYS CYS A . n 
A 1 79  GLU 79  107 107 GLU GLU A . n 
A 1 80  PHE 80  108 108 PHE PHE A . n 
A 1 81  TRP 81  109 109 TRP TRP A . n 
A 1 82  THR 82  110 110 THR THR A . n 
A 1 83  SER 83  111 111 SER SER A . n 
A 1 84  ILE 84  112 112 ILE ILE A . n 
A 1 85  ASP 85  113 113 ASP ASP A . n 
A 1 86  VAL 86  114 114 VAL VAL A . n 
A 1 87  LEU 87  115 115 LEU LEU A . n 
A 1 88  CYS 88  116 116 CYS CYS A . n 
A 1 89  VAL 89  117 117 VAL VAL A . n 
A 1 90  THR 90  118 118 THR THR A . n 
A 1 91  ALA 91  119 119 ALA ALA A . n 
A 1 92  SER 92  120 120 SER SER A . n 
A 1 93  ILE 93  121 121 ILE ILE A . n 
A 1 94  GLU 94  122 122 GLU GLU A . n 
A 1 95  THR 95  123 123 THR THR A . n 
A 1 96  LEU 96  124 124 LEU LEU A . n 
A 1 97  CYS 97  125 125 CYS CYS A . n 
A 1 98  VAL 98  126 126 VAL VAL A . n 
A 1 99  ILE 99  127 127 ILE ILE A . n 
A 1 100 ALA 100 128 128 ALA ALA A . n 
A 1 101 VAL 101 129 129 VAL VAL A . n 
A 1 102 ASP 102 130 130 ASP ASP A . n 
A 1 103 ARG 103 131 131 ARG ARG A . n 
A 1 104 TYR 104 132 132 TYR TYR A . n 
A 1 105 PHE 105 133 133 PHE PHE A . n 
A 1 106 ALA 106 134 134 ALA ALA A . n 
A 1 107 ILE 107 135 135 ILE ILE A . n 
A 1 108 THR 108 136 136 THR THR A . n 
A 1 109 SER 109 137 137 SER SER A . n 
A 1 110 PRO 110 138 138 PRO PRO A . n 
A 1 111 PHE 111 139 139 PHE PHE A . n 
A 1 112 LYS 112 140 140 LYS LYS A . n 
A 1 113 TYR 113 141 141 TYR TYR A . n 
A 1 114 GLN 114 142 142 GLN GLN A . n 
A 1 115 SER 115 143 143 SER SER A . n 
A 1 116 LEU 116 144 144 LEU LEU A . n 
A 1 117 LEU 117 145 145 LEU LEU A . n 
A 1 118 THR 118 146 146 THR THR A . n 
A 1 119 LYS 119 147 147 LYS LYS A . n 
A 1 120 ASN 120 148 148 ASN ASN A . n 
A 1 121 LYS 121 149 149 LYS LYS A . n 
A 1 122 ALA 122 150 150 ALA ALA A . n 
A 1 123 ARG 123 151 151 ARG ARG A . n 
A 1 124 VAL 124 152 152 VAL VAL A . n 
A 1 125 ILE 125 153 153 ILE ILE A . n 
A 1 126 ILE 126 154 154 ILE ILE A . n 
A 1 127 LEU 127 155 155 LEU LEU A . n 
A 1 128 MET 128 156 156 MET MET A . n 
A 1 129 VAL 129 157 157 VAL VAL A . n 
A 1 130 TRP 130 158 158 TRP TRP A . n 
A 1 131 ILE 131 159 159 ILE ILE A . n 
A 1 132 VAL 132 160 160 VAL VAL A . n 
A 1 133 SER 133 161 161 SER SER A . n 
A 1 134 GLY 134 162 162 GLY GLY A . n 
A 1 135 LEU 135 163 163 LEU LEU A . n 
A 1 136 THR 136 164 164 THR THR A . n 
A 1 137 SER 137 165 165 SER SER A . n 
A 1 138 PHE 138 166 166 PHE PHE A . n 
A 1 139 LEU 139 167 167 LEU LEU A . n 
A 1 140 PRO 140 168 168 PRO PRO A . n 
A 1 141 ILE 141 169 169 ILE ILE A . n 
A 1 142 GLN 142 170 170 GLN GLN A . n 
A 1 143 MET 143 171 171 MET MET A . n 
A 1 144 HIS 144 172 172 HIS HIS A . n 
A 1 145 TRP 145 173 173 TRP TRP A . n 
A 1 146 TYR 146 174 174 TYR TYR A . n 
A 1 147 ARG 147 175 175 ARG ARG A . n 
A 1 148 ALA 148 176 176 ALA ALA A . n 
A 1 149 THR 149 177 177 THR THR A . n 
A 1 150 HIS 150 178 178 HIS HIS A . n 
A 1 151 GLN 151 179 179 GLN GLN A . n 
A 1 152 GLU 152 180 180 GLU GLU A . n 
A 1 153 ALA 153 181 181 ALA ALA A . n 
A 1 154 ILE 154 182 182 ILE ILE A . n 
A 1 155 ASN 155 183 183 ASN ASN A . n 
A 1 156 CYS 156 184 184 CYS CYS A . n 
A 1 157 TYR 157 185 185 TYR TYR A . n 
A 1 158 ALA 158 186 186 ALA ALA A . n 
A 1 159 GLU 159 187 187 GLU GLU A . n 
A 1 160 GLU 160 188 188 GLU GLU A . n 
A 1 161 THR 161 189 189 THR THR A . n 
A 1 162 CYS 162 190 190 CYS CYS A . n 
A 1 163 CYS 163 191 191 CYS CYS A . n 
A 1 164 ASP 164 192 192 ASP ASP A . n 
A 1 165 PHE 165 193 193 PHE PHE A . n 
A 1 166 PHE 166 194 194 PHE PHE A . n 
A 1 167 THR 167 195 195 THR THR A . n 
A 1 168 ASN 168 196 196 ASN ASN A . n 
A 1 169 GLN 169 197 197 GLN GLN A . n 
A 1 170 ALA 170 198 198 ALA ALA A . n 
A 1 171 TYR 171 199 199 TYR TYR A . n 
A 1 172 ALA 172 200 200 ALA ALA A . n 
A 1 173 ILE 173 201 201 ILE ILE A . n 
A 1 174 ALA 174 202 202 ALA ALA A . n 
A 1 175 SER 175 203 203 SER SER A . n 
A 1 176 SER 176 204 204 SER SER A . n 
A 1 177 ILE 177 205 205 ILE ILE A . n 
A 1 178 VAL 178 206 206 VAL VAL A . n 
A 1 179 SER 179 207 207 SER SER A . n 
A 1 180 PHE 180 208 208 PHE PHE A . n 
A 1 181 TYR 181 209 209 TYR TYR A . n 
A 1 182 VAL 182 210 210 VAL VAL A . n 
A 1 183 PRO 183 211 211 PRO PRO A . n 
A 1 184 LEU 184 212 212 LEU LEU A . n 
A 1 185 VAL 185 213 213 VAL VAL A . n 
A 1 186 ILE 186 214 214 ILE ILE A . n 
A 1 187 MET 187 215 215 MET MET A . n 
A 1 188 VAL 188 216 216 VAL VAL A . n 
A 1 189 PHE 189 217 217 PHE PHE A . n 
A 1 190 VAL 190 218 218 VAL VAL A . n 
A 1 191 TYR 191 219 219 TYR TYR A . n 
A 1 192 SER 192 220 220 SER SER A . n 
A 1 193 ARG 193 221 221 ARG ARG A . n 
A 1 194 VAL 194 222 222 VAL VAL A . n 
A 1 195 PHE 195 223 223 PHE PHE A . n 
A 1 196 GLN 196 224 224 GLN GLN A . n 
A 1 197 GLU 197 225 225 GLU GLU A . n 
A 1 198 ALA 198 226 226 ALA ALA A . n 
A 1 199 LYS 199 227 227 LYS LYS A . n 
A 1 200 ARG 200 228 228 ARG ARG A . n 
A 1 201 GLN 201 229 229 GLN GLN A . n 
A 1 202 LEU 202 230 230 LEU LEU A . n 
A 1 203 ASP 203 231 231 ASP ASP A . n 
A 1 204 ALA 204 232 232 ALA ALA A . n 
A 1 205 ASP 205 233 233 ASP ASP A . n 
A 1 206 GLU 206 234 234 GLU GLU A . n 
A 1 207 ILE 207 235 235 ILE ILE A . n 
A 1 208 LYS 208 236 236 LYS LYS A . n 
A 1 209 ARG 209 237 237 ARG ARG A . n 
A 1 210 LEU 210 238 238 LEU LEU A . n 
A 1 211 GLY 211 239 239 GLY GLY A . n 
A 1 212 LYS 212 240 240 LYS LYS A . n 
A 1 213 ARG 213 241 241 ARG ARG A . n 
A 1 214 PHE 214 242 242 PHE PHE A . n 
A 1 215 LYS 215 243 243 LYS LYS A . n 
A 1 216 LYS 216 244 244 LYS LYS A . n 
A 1 217 LEU 217 245 245 LEU LEU A . n 
A 1 218 ASP 218 246 246 ASP ASP A . n 
A 1 219 LEU 219 247 247 LEU LEU A . n 
A 1 220 ASP 220 248 248 ASP ASP A . n 
A 1 221 ASN 221 249 249 ASN ASN A . n 
A 1 222 SER 222 250 250 SER SER A . n 
A 1 223 GLY 223 251 251 GLY GLY A . n 
A 1 224 SER 224 252 252 SER SER A . n 
A 1 225 LEU 225 253 253 LEU LEU A . n 
A 1 226 SER 226 254 254 SER SER A . n 
A 1 227 VAL 227 255 255 VAL VAL A . n 
A 1 228 GLU 228 256 256 GLU GLU A . n 
A 1 229 GLU 229 257 257 GLU GLU A . n 
A 1 230 PHE 230 258 258 PHE PHE A . n 
A 1 231 MET 231 259 259 MET MET A . n 
A 1 232 SER 232 260 260 SER SER A . n 
A 1 233 LEU 233 261 261 LEU LEU A . n 
A 1 234 PRO 234 262 262 PRO PRO A . n 
A 1 235 GLU 235 263 263 GLU GLU A . n 
A 1 236 LEU 236 264 264 LEU LEU A . n 
A 1 237 GLN 237 265 265 GLN GLN A . n 
A 1 238 GLN 238 266 266 GLN GLN A . n 
A 1 239 ASN 239 267 267 ASN ASN A . n 
A 1 240 PRO 240 268 268 PRO PRO A . n 
A 1 241 LEU 241 269 269 LEU LEU A . n 
A 1 242 VAL 242 270 270 VAL VAL A . n 
A 1 243 GLN 243 271 271 GLN GLN A . n 
A 1 244 ARG 244 272 272 ARG ARG A . n 
A 1 245 VAL 245 273 273 VAL VAL A . n 
A 1 246 ILE 246 274 274 ILE ILE A . n 
A 1 247 ASP 247 275 275 ASP ASP A . n 
A 1 248 ILE 248 276 276 ILE ILE A . n 
A 1 249 PHE 249 277 277 PHE PHE A . n 
A 1 250 ASP 250 278 278 ASP ASP A . n 
A 1 251 THR 251 279 279 THR THR A . n 
A 1 252 ASP 252 280 280 ASP ASP A . n 
A 1 253 GLY 253 281 281 GLY GLY A . n 
A 1 254 ASN 254 282 282 ASN ASN A . n 
A 1 255 GLY 255 283 283 GLY GLY A . n 
A 1 256 GLU 256 284 284 GLU GLU A . n 
A 1 257 VAL 257 285 285 VAL VAL A . n 
A 1 258 ASP 258 286 286 ASP ASP A . n 
A 1 259 PHE 259 287 287 PHE PHE A . n 
A 1 260 LYS 260 288 288 LYS LYS A . n 
A 1 261 GLU 261 289 289 GLU GLU A . n 
A 1 262 PHE 262 290 290 PHE PHE A . n 
A 1 263 ILE 263 291 291 ILE ILE A . n 
A 1 264 GLU 264 292 292 GLU GLU A . n 
A 1 265 GLY 265 293 293 GLY GLY A . n 
A 1 266 VAL 266 294 294 VAL VAL A . n 
A 1 267 SER 267 295 295 SER SER A . n 
A 1 268 GLN 268 296 296 GLN GLN A . n 
A 1 269 PHE 269 297 297 PHE PHE A . n 
A 1 270 SER 270 298 298 SER SER A . n 
A 1 271 VAL 271 299 299 VAL VAL A . n 
A 1 272 LYS 272 300 300 LYS LYS A . n 
A 1 273 GLY 273 301 301 GLY GLY A . n 
A 1 274 ASP 274 302 302 ASP ASP A . n 
A 1 275 LYS 275 303 303 LYS LYS A . n 
A 1 276 GLU 276 304 304 GLU GLU A . n 
A 1 277 GLN 277 305 305 GLN GLN A . n 
A 1 278 LYS 278 306 306 LYS LYS A . n 
A 1 279 LEU 279 307 307 LEU LEU A . n 
A 1 280 ARG 280 308 308 ARG ARG A . n 
A 1 281 PHE 281 309 309 PHE PHE A . n 
A 1 282 ALA 282 310 310 ALA ALA A . n 
A 1 283 PHE 283 311 311 PHE PHE A . n 
A 1 284 ARG 284 312 312 ARG ARG A . n 
A 1 285 ILE 285 313 313 ILE ILE A . n 
A 1 286 TYR 286 314 314 TYR TYR A . n 
A 1 287 ASP 287 315 315 ASP ASP A . n 
A 1 288 MET 288 316 316 MET MET A . n 
A 1 289 ASP 289 317 317 ASP ASP A . n 
A 1 290 LYS 290 318 318 LYS LYS A . n 
A 1 291 ASP 291 319 319 ASP ASP A . n 
A 1 292 GLY 292 320 320 GLY GLY A . n 
A 1 293 TYR 293 321 321 TYR TYR A . n 
A 1 294 ILE 294 322 322 ILE ILE A . n 
A 1 295 SER 295 323 323 SER SER A . n 
A 1 296 ASN 296 324 324 ASN ASN A . n 
A 1 297 GLY 297 325 325 GLY GLY A . n 
A 1 298 GLU 298 326 326 GLU GLU A . n 
A 1 299 LEU 299 327 327 LEU LEU A . n 
A 1 300 PHE 300 328 328 PHE PHE A . n 
A 1 301 GLN 301 329 329 GLN GLN A . n 
A 1 302 VAL 302 330 330 VAL VAL A . n 
A 1 303 LEU 303 331 331 LEU LEU A . n 
A 1 304 LYS 304 332 332 LYS LYS A . n 
A 1 305 MET 305 333 333 MET MET A . n 
A 1 306 MET 306 334 334 MET MET A . n 
A 1 307 VAL 307 335 335 VAL VAL A . n 
A 1 308 GLY 308 336 336 GLY GLY A . n 
A 1 309 ASN 309 337 337 ASN ASN A . n 
A 1 310 ASN 310 338 338 ASN ASN A . n 
A 1 311 LEU 311 339 339 LEU LEU A . n 
A 1 312 LYS 312 340 340 LYS LYS A . n 
A 1 313 ASP 313 341 341 ASP ASP A . n 
A 1 314 THR 314 342 342 THR THR A . n 
A 1 315 GLN 315 343 343 GLN GLN A . n 
A 1 316 LEU 316 344 344 LEU LEU A . n 
A 1 317 GLN 317 345 345 GLN GLN A . n 
A 1 318 GLN 318 346 346 GLN GLN A . n 
A 1 319 ILE 319 347 347 ILE ILE A . n 
A 1 320 VAL 320 348 348 VAL VAL A . n 
A 1 321 ASP 321 349 349 ASP ASP A . n 
A 1 322 LYS 322 350 350 LYS LYS A . n 
A 1 323 THR 323 351 351 THR THR A . n 
A 1 324 ILE 324 352 352 ILE ILE A . n 
A 1 325 ILE 325 353 353 ILE ILE A . n 
A 1 326 ASN 326 354 354 ASN ASN A . n 
A 1 327 ALA 327 355 355 ALA ALA A . n 
A 1 328 ASP 328 356 356 ASP ASP A . n 
A 1 329 LYS 329 357 357 LYS LYS A . n 
A 1 330 ASP 330 358 358 ASP ASP A . n 
A 1 331 GLY 331 359 359 GLY GLY A . n 
A 1 332 ASP 332 360 360 ASP ASP A . n 
A 1 333 GLY 333 361 361 GLY GLY A . n 
A 1 334 ARG 334 362 362 ARG ARG A . n 
A 1 335 ILE 335 363 363 ILE ILE A . n 
A 1 336 SER 336 364 364 SER SER A . n 
A 1 337 PHE 337 365 365 PHE PHE A . n 
A 1 338 GLU 338 366 366 GLU GLU A . n 
A 1 339 GLU 339 367 367 GLU GLU A . n 
A 1 340 PHE 340 368 368 PHE PHE A . n 
A 1 341 CYS 341 369 369 CYS CYS A . n 
A 1 342 ALA 342 370 370 ALA ALA A . n 
A 1 343 VAL 343 371 371 VAL VAL A . n 
A 1 344 VAL 344 372 372 VAL VAL A . n 
A 1 345 GLY 345 373 373 GLY GLY A . n 
A 1 346 GLY 346 374 374 GLY GLY A . n 
A 1 347 LEU 347 375 375 LEU LEU A . n 
A 1 348 ASP 348 376 376 ASP ASP A . n 
A 1 349 ILE 349 377 377 ILE ILE A . n 
A 1 350 HIS 350 378 378 HIS HIS A . n 
A 1 351 LYS 351 379 379 LYS LYS A . n 
A 1 352 LYS 352 380 380 LYS LYS A . n 
A 1 353 MET 353 381 381 MET MET A . n 
A 1 354 VAL 354 382 382 VAL VAL A . n 
A 1 355 VAL 355 383 383 VAL VAL A . n 
A 1 356 ASP 356 384 384 ASP ASP A . n 
A 1 357 VAL 357 385 385 VAL VAL A . n 
A 1 358 LYS 358 386 386 LYS LYS A . n 
A 1 359 PHE 359 387 387 PHE PHE A . n 
A 1 360 CYS 360 388 388 CYS CYS A . n 
A 1 361 LEU 361 389 389 LEU LEU A . n 
A 1 362 LYS 362 390 390 LYS LYS A . n 
A 1 363 GLU 363 391 391 GLU GLU A . n 
A 1 364 HIS 364 392 392 HIS HIS A . n 
A 1 365 LYS 365 393 393 LYS LYS A . n 
A 1 366 ALA 366 394 394 ALA ALA A . n 
A 1 367 LEU 367 395 395 LEU LEU A . n 
A 1 368 LYS 368 396 396 LYS LYS A . n 
A 1 369 THR 369 397 397 THR THR A . n 
A 1 370 LEU 370 398 398 LEU LEU A . n 
A 1 371 GLY 371 399 399 GLY GLY A . n 
A 1 372 ILE 372 400 400 ILE ILE A . n 
A 1 373 ILE 373 401 401 ILE ILE A . n 
A 1 374 MET 374 402 402 MET MET A . n 
A 1 375 GLY 375 403 403 GLY GLY A . n 
A 1 376 THR 376 404 404 THR THR A . n 
A 1 377 PHE 377 405 405 PHE PHE A . n 
A 1 378 THR 378 406 406 THR THR A . n 
A 1 379 LEU 379 407 407 LEU LEU A . n 
A 1 380 CYS 380 408 408 CYS CYS A . n 
A 1 381 TRP 381 409 409 TRP TRP A . n 
A 1 382 LEU 382 410 410 LEU LEU A . n 
A 1 383 PRO 383 411 411 PRO PRO A . n 
A 1 384 PHE 384 412 412 PHE PHE A . n 
A 1 385 PHE 385 413 413 PHE PHE A . n 
A 1 386 ILE 386 414 414 ILE ILE A . n 
A 1 387 VAL 387 415 415 VAL VAL A . n 
A 1 388 ASN 388 416 416 ASN ASN A . n 
A 1 389 ILE 389 417 417 ILE ILE A . n 
A 1 390 VAL 390 418 418 VAL VAL A . n 
A 1 391 HIS 391 419 419 HIS HIS A . n 
A 1 392 VAL 392 420 420 VAL VAL A . n 
A 1 393 ILE 393 421 421 ILE ILE A . n 
A 1 394 GLN 394 422 422 GLN GLN A . n 
A 1 395 ASP 395 423 423 ASP ASP A . n 
A 1 396 ASN 396 424 424 ASN ASN A . n 
A 1 397 LEU 397 425 425 LEU LEU A . n 
A 1 398 ILE 398 426 426 ILE ILE A . n 
A 1 399 ARG 399 427 427 ARG ARG A . n 
A 1 400 LYS 400 428 428 LYS LYS A . n 
A 1 401 GLU 401 429 429 GLU GLU A . n 
A 1 402 VAL 402 430 430 VAL VAL A . n 
A 1 403 TYR 403 431 431 TYR TYR A . n 
A 1 404 ILE 404 432 432 ILE ILE A . n 
A 1 405 LEU 405 433 433 LEU LEU A . n 
A 1 406 LEU 406 434 434 LEU LEU A . n 
A 1 407 ASN 407 435 435 ASN ASN A . n 
A 1 408 TRP 408 436 436 TRP TRP A . n 
A 1 409 ILE 409 437 437 ILE ILE A . n 
A 1 410 GLY 410 438 438 GLY GLY A . n 
A 1 411 TYR 411 439 439 TYR TYR A . n 
A 1 412 VAL 412 440 440 VAL VAL A . n 
A 1 413 ASN 413 441 441 ASN ASN A . n 
A 1 414 SER 414 442 442 SER SER A . n 
A 1 415 GLY 415 443 443 GLY GLY A . n 
A 1 416 PHE 416 444 444 PHE PHE A . n 
A 1 417 ASN 417 445 445 ASN ASN A . n 
A 1 418 PRO 418 446 446 PRO PRO A . n 
A 1 419 LEU 419 447 447 LEU LEU A . n 
A 1 420 ILE 420 448 448 ILE ILE A . n 
A 1 421 TYR 421 449 449 TYR TYR A . n 
A 1 422 CYS 422 450 450 CYS CYS A . n 
A 1 423 ARG 423 451 451 ARG ARG A . n 
A 1 424 SER 424 452 452 SER SER A . n 
A 1 425 PRO 425 453 453 PRO PRO A . n 
A 1 426 ASP 426 454 454 ASP ASP A . n 
A 1 427 PHE 427 455 455 PHE PHE A . n 
A 1 428 ARG 428 456 456 ARG ARG A . n 
A 1 429 ILE 429 457 457 ILE ILE A . n 
A 1 430 ALA 430 458 458 ALA ALA A . n 
A 1 431 PHE 431 459 459 PHE PHE A . n 
A 1 432 GLN 432 460 460 GLN GLN A . n 
A 1 433 GLU 433 461 461 GLU GLU A . n 
A 1 434 LEU 434 462 462 LEU LEU A . n 
A 1 435 LEU 435 463 463 LEU LEU A . n 
A 1 436 CYS 436 464 ?   ?   ?   A . n 
A 1 437 LEU 437 465 ?   ?   ?   A . n 
A 1 438 ARG 438 466 ?   ?   ?   A . n 
A 1 439 ARG 439 467 ?   ?   ?   A . n 
A 1 440 ASP 440 468 ?   ?   ?   A . n 
A 1 441 ASP 441 469 ?   ?   ?   A . n 
A 1 442 LEU 442 470 ?   ?   ?   A . n 
A 1 443 LYS 443 471 ?   ?   ?   A . n 
A 1 444 ALA 444 472 ?   ?   ?   A . n 
A 1 445 TYR 445 473 ?   ?   ?   A . n 
A 1 446 GLY 446 474 ?   ?   ?   A . n 
A 1 447 ASN 447 475 ?   ?   ?   A . n 
A 1 448 GLY 448 476 ?   ?   ?   A . n 
A 1 449 TYR 449 477 ?   ?   ?   A . n 
B 2 1   SER 1   1   ?   ?   ?   B . n 
B 2 2   GLU 2   2   ?   ?   ?   B . n 
B 2 3   PRO 3   3   ?   ?   ?   B . n 
B 2 4   LYS 4   4   ?   ?   ?   B . n 
B 2 5   ALA 5   5   ?   ?   ?   B . n 
B 2 6   ILE 6   6   ?   ?   ?   B . n 
B 2 7   ASP 7   7   ?   ?   ?   B . n 
B 2 8   PRO 8   8   ?   ?   ?   B . n 
B 2 9   LYS 9   9   ?   ?   ?   B . n 
B 2 10  LEU 10  10  ?   ?   ?   B . n 
B 2 11  SER 11  11  ?   ?   ?   B . n 
B 2 12  THR 12  12  ?   ?   ?   B . n 
B 2 13  THR 13  13  13  THR THR B . n 
B 2 14  ASP 14  14  14  ASP ASP B . n 
B 2 15  ARG 15  15  15  ARG ARG B . n 
B 2 16  VAL 16  16  16  VAL VAL B . n 
B 2 17  VAL 17  17  17  VAL VAL B . n 
B 2 18  LYS 18  18  18  LYS LYS B . n 
B 2 19  ALA 19  19  19  ALA ALA B . n 
B 2 20  VAL 20  20  20  VAL VAL B . n 
B 2 21  PRO 21  21  21  PRO PRO B . n 
B 2 22  PHE 22  22  22  PHE PHE B . n 
B 2 23  PRO 23  23  23  PRO PRO B . n 
B 2 24  PRO 24  24  24  PRO PRO B . n 
B 2 25  SER 25  25  25  SER SER B . n 
B 2 26  HIS 26  26  26  HIS HIS B . n 
B 2 27  ARG 27  27  27  ARG ARG B . n 
B 2 28  LEU 28  28  28  LEU LEU B . n 
B 2 29  THR 29  29  29  THR THR B . n 
B 2 30  ALA 30  30  30  ALA ALA B . n 
B 2 31  LYS 31  31  31  LYS LYS B . n 
B 2 32  GLU 32  32  32  GLU GLU B . n 
B 2 33  VAL 33  33  33  VAL VAL B . n 
B 2 34  PHE 34  34  34  PHE PHE B . n 
B 2 35  ASP 35  35  35  ASP ASP B . n 
B 2 36  ASN 36  36  ?   ?   ?   B . n 
B 2 37  ASP 37  37  ?   ?   ?   B . n 
B 2 38  GLY 38  38  38  GLY GLY B . n 
B 2 39  LYS 39  39  39  LYS LYS B . n 
B 2 40  PRO 40  40  40  PRO PRO B . n 
B 2 41  ARG 41  41  41  ARG ARG B . n 
B 2 42  VAL 42  42  42  VAL VAL B . n 
B 2 43  ASP 43  43  43  ASP ASP B . n 
B 2 44  ILE 44  44  44  ILE ILE B . n 
B 2 45  LEU 45  45  45  LEU LEU B . n 
B 2 46  LYS 46  46  46  LYS LYS B . n 
B 2 47  ALA 47  47  47  ALA ALA B . n 
B 2 48  HIS 48  48  48  HIS HIS B . n 
B 2 49  LEU 49  49  49  LEU LEU B . n 
B 2 50  MET 50  50  50  MET MET B . n 
B 2 51  LYS 51  51  51  LYS LYS B . n 
B 2 52  GLU 52  52  52  GLU GLU B . n 
B 2 53  GLY 53  53  53  GLY GLY B . n 
B 2 54  ARG 54  54  54  ARG ARG B . n 
B 2 55  LEU 55  55  55  LEU LEU B . n 
B 2 56  GLU 56  56  56  GLU GLU B . n 
B 2 57  GLU 57  57  57  GLU GLU B . n 
B 2 58  SER 58  58  58  SER SER B . n 
B 2 59  VAL 59  59  59  VAL VAL B . n 
B 2 60  ALA 60  60  60  ALA ALA B . n 
B 2 61  LEU 61  61  61  LEU LEU B . n 
B 2 62  ARG 62  62  62  ARG ARG B . n 
B 2 63  ILE 63  63  63  ILE ILE B . n 
B 2 64  ILE 64  64  64  ILE ILE B . n 
B 2 65  THR 65  65  65  THR THR B . n 
B 2 66  GLU 66  66  66  GLU GLU B . n 
B 2 67  GLY 67  67  67  GLY GLY B . n 
B 2 68  ALA 68  68  68  ALA ALA B . n 
B 2 69  SER 69  69  69  SER SER B . n 
B 2 70  ILE 70  70  70  ILE ILE B . n 
B 2 71  LEU 71  71  71  LEU LEU B . n 
B 2 72  ARG 72  72  72  ARG ARG B . n 
B 2 73  GLN 73  73  73  GLN GLN B . n 
B 2 74  GLU 74  74  74  GLU GLU B . n 
B 2 75  LYS 75  75  75  LYS LYS B . n 
B 2 76  ASN 76  76  76  ASN ASN B . n 
B 2 77  LEU 77  77  77  LEU LEU B . n 
B 2 78  LEU 78  78  78  LEU LEU B . n 
B 2 79  ASP 79  79  79  ASP ASP B . n 
B 2 80  ILE 80  80  80  ILE ILE B . n 
B 2 81  ASP 81  81  81  ASP ASP B . n 
B 2 82  ALA 82  82  82  ALA ALA B . n 
B 2 83  PRO 83  83  83  PRO PRO B . n 
B 2 84  VAL 84  84  84  VAL VAL B . n 
B 2 85  THR 85  85  85  THR THR B . n 
B 2 86  VAL 86  86  86  VAL VAL B . n 
B 2 87  CYS 87  87  87  CYS CYS B . n 
B 2 88  GLY 88  88  88  GLY GLY B . n 
B 2 89  ASP 89  89  89  ASP ASP B . n 
B 2 90  ILE 90  90  90  ILE ILE B . n 
B 2 91  HIS 91  91  91  HIS HIS B . n 
B 2 92  GLY 92  92  92  GLY GLY B . n 
B 2 93  GLN 93  93  93  GLN GLN B . n 
B 2 94  PHE 94  94  94  PHE PHE B . n 
B 2 95  PHE 95  95  95  PHE PHE B . n 
B 2 96  ASP 96  96  96  ASP ASP B . n 
B 2 97  LEU 97  97  97  LEU LEU B . n 
B 2 98  MET 98  98  98  MET MET B . n 
B 2 99  LYS 99  99  99  LYS LYS B . n 
B 2 100 LEU 100 100 100 LEU LEU B . n 
B 2 101 PHE 101 101 101 PHE PHE B . n 
B 2 102 GLU 102 102 102 GLU GLU B . n 
B 2 103 VAL 103 103 103 VAL VAL B . n 
B 2 104 GLY 104 104 104 GLY GLY B . n 
B 2 105 GLY 105 105 105 GLY GLY B . n 
B 2 106 SER 106 106 106 SER SER B . n 
B 2 107 PRO 107 107 107 PRO PRO B . n 
B 2 108 ALA 108 108 108 ALA ALA B . n 
B 2 109 ASN 109 109 109 ASN ASN B . n 
B 2 110 THR 110 110 110 THR THR B . n 
B 2 111 ARG 111 111 111 ARG ARG B . n 
B 2 112 TYR 112 112 112 TYR TYR B . n 
B 2 113 LEU 113 113 113 LEU LEU B . n 
B 2 114 PHE 114 114 114 PHE PHE B . n 
B 2 115 LEU 115 115 115 LEU LEU B . n 
B 2 116 GLY 116 116 116 GLY GLY B . n 
B 2 117 ASP 117 117 117 ASP ASP B . n 
B 2 118 TYR 118 118 118 TYR TYR B . n 
B 2 119 VAL 119 119 119 VAL VAL B . n 
B 2 120 ASP 120 120 120 ASP ASP B . n 
B 2 121 ARG 121 121 121 ARG ARG B . n 
B 2 122 GLY 122 122 122 GLY GLY B . n 
B 2 123 TYR 123 123 123 TYR TYR B . n 
B 2 124 PHE 124 124 124 PHE PHE B . n 
B 2 125 SER 125 125 125 SER SER B . n 
B 2 126 ILE 126 126 126 ILE ILE B . n 
B 2 127 GLU 127 127 127 GLU GLU B . n 
B 2 128 CYS 128 128 128 CYS CYS B . n 
B 2 129 VAL 129 129 129 VAL VAL B . n 
B 2 130 LEU 130 130 130 LEU LEU B . n 
B 2 131 TYR 131 131 131 TYR TYR B . n 
B 2 132 LEU 132 132 132 LEU LEU B . n 
B 2 133 TRP 133 133 133 TRP TRP B . n 
B 2 134 ALA 134 134 134 ALA ALA B . n 
B 2 135 LEU 135 135 135 LEU LEU B . n 
B 2 136 LYS 136 136 136 LYS LYS B . n 
B 2 137 ILE 137 137 137 ILE ILE B . n 
B 2 138 LEU 138 138 138 LEU LEU B . n 
B 2 139 TYR 139 139 139 TYR TYR B . n 
B 2 140 PRO 140 140 140 PRO PRO B . n 
B 2 141 LYS 141 141 141 LYS LYS B . n 
B 2 142 THR 142 142 142 THR THR B . n 
B 2 143 LEU 143 143 143 LEU LEU B . n 
B 2 144 PHE 144 144 144 PHE PHE B . n 
B 2 145 LEU 145 145 145 LEU LEU B . n 
B 2 146 LEU 146 146 146 LEU LEU B . n 
B 2 147 ARG 147 147 147 ARG ARG B . n 
B 2 148 GLY 148 148 148 GLY GLY B . n 
B 2 149 ASN 149 149 149 ASN ASN B . n 
B 2 150 HIS 150 150 150 HIS HIS B . n 
B 2 151 GLU 151 151 151 GLU GLU B . n 
B 2 152 CYS 152 152 152 CYS CYS B . n 
B 2 153 ARG 153 153 153 ARG ARG B . n 
B 2 154 HIS 154 154 154 HIS HIS B . n 
B 2 155 LEU 155 155 155 LEU LEU B . n 
B 2 156 THR 156 156 156 THR THR B . n 
B 2 157 GLU 157 157 157 GLU GLU B . n 
B 2 158 TYR 158 158 158 TYR TYR B . n 
B 2 159 PHE 159 159 159 PHE PHE B . n 
B 2 160 THR 160 160 160 THR THR B . n 
B 2 161 PHE 161 161 161 PHE PHE B . n 
B 2 162 LYS 162 162 162 LYS LYS B . n 
B 2 163 GLN 163 163 163 GLN GLN B . n 
B 2 164 GLU 164 164 164 GLU GLU B . n 
B 2 165 CYS 165 165 165 CYS CYS B . n 
B 2 166 LYS 166 166 166 LYS LYS B . n 
B 2 167 ILE 167 167 167 ILE ILE B . n 
B 2 168 LYS 168 168 168 LYS LYS B . n 
B 2 169 TYR 169 169 169 TYR TYR B . n 
B 2 170 SER 170 170 170 SER SER B . n 
B 2 171 GLU 171 171 171 GLU GLU B . n 
B 2 172 ARG 172 172 172 ARG ARG B . n 
B 2 173 VAL 173 173 173 VAL VAL B . n 
B 2 174 TYR 174 174 174 TYR TYR B . n 
B 2 175 ASP 175 175 175 ASP ASP B . n 
B 2 176 ALA 176 176 176 ALA ALA B . n 
B 2 177 CYS 177 177 177 CYS CYS B . n 
B 2 178 MET 178 178 178 MET MET B . n 
B 2 179 ASP 179 179 179 ASP ASP B . n 
B 2 180 ALA 180 180 180 ALA ALA B . n 
B 2 181 PHE 181 181 181 PHE PHE B . n 
B 2 182 ASP 182 182 182 ASP ASP B . n 
B 2 183 CYS 183 183 183 CYS CYS B . n 
B 2 184 LEU 184 184 184 LEU LEU B . n 
B 2 185 PRO 185 185 185 PRO PRO B . n 
B 2 186 LEU 186 186 186 LEU LEU B . n 
B 2 187 ALA 187 187 187 ALA ALA B . n 
B 2 188 ALA 188 188 188 ALA ALA B . n 
B 2 189 LEU 189 189 189 LEU LEU B . n 
B 2 190 MET 190 190 190 MET MET B . n 
B 2 191 ASN 191 191 191 ASN ASN B . n 
B 2 192 GLN 192 192 192 GLN GLN B . n 
B 2 193 GLN 193 193 193 GLN GLN B . n 
B 2 194 PHE 194 194 194 PHE PHE B . n 
B 2 195 LEU 195 195 195 LEU LEU B . n 
B 2 196 CYS 196 196 196 CYS CYS B . n 
B 2 197 VAL 197 197 197 VAL VAL B . n 
B 2 198 HIS 198 198 198 HIS HIS B . n 
B 2 199 GLY 199 199 199 GLY GLY B . n 
B 2 200 GLY 200 200 200 GLY GLY B . n 
B 2 201 LEU 201 201 201 LEU LEU B . n 
B 2 202 SER 202 202 202 SER SER B . n 
B 2 203 PRO 203 203 203 PRO PRO B . n 
B 2 204 GLU 204 204 204 GLU GLU B . n 
B 2 205 ILE 205 205 205 ILE ILE B . n 
B 2 206 ASN 206 206 206 ASN ASN B . n 
B 2 207 THR 207 207 207 THR THR B . n 
B 2 208 LEU 208 208 208 LEU LEU B . n 
B 2 209 ASP 209 209 209 ASP ASP B . n 
B 2 210 ASP 210 210 210 ASP ASP B . n 
B 2 211 ILE 211 211 211 ILE ILE B . n 
B 2 212 ARG 212 212 212 ARG ARG B . n 
B 2 213 LYS 213 213 213 LYS LYS B . n 
B 2 214 LEU 214 214 214 LEU LEU B . n 
B 2 215 ASP 215 215 215 ASP ASP B . n 
B 2 216 ARG 216 216 216 ARG ARG B . n 
B 2 217 PHE 217 217 217 PHE PHE B . n 
B 2 218 LYS 218 218 218 LYS LYS B . n 
B 2 219 GLU 219 219 219 GLU GLU B . n 
B 2 220 PRO 220 220 220 PRO PRO B . n 
B 2 221 PRO 221 221 221 PRO PRO B . n 
B 2 222 ALA 222 222 222 ALA ALA B . n 
B 2 223 TYR 223 223 223 TYR TYR B . n 
B 2 224 GLY 224 224 224 GLY GLY B . n 
B 2 225 PRO 225 225 225 PRO PRO B . n 
B 2 226 MET 226 226 226 MET MET B . n 
B 2 227 CYS 227 227 227 CYS CYS B . n 
B 2 228 ASP 228 228 228 ASP ASP B . n 
B 2 229 ILE 229 229 229 ILE ILE B . n 
B 2 230 LEU 230 230 230 LEU LEU B . n 
B 2 231 TRP 231 231 231 TRP TRP B . n 
B 2 232 SER 232 232 232 SER SER B . n 
B 2 233 ASP 233 233 233 ASP ASP B . n 
B 2 234 PRO 234 234 234 PRO PRO B . n 
B 2 235 LEU 235 235 235 LEU LEU B . n 
B 2 236 GLU 236 236 236 GLU GLU B . n 
B 2 237 ASP 237 237 237 ASP ASP B . n 
B 2 238 PHE 238 238 238 PHE PHE B . n 
B 2 239 GLY 239 239 239 GLY GLY B . n 
B 2 240 ASN 240 240 240 ASN ASN B . n 
B 2 241 GLU 241 241 ?   ?   ?   B . n 
B 2 242 LYS 242 242 ?   ?   ?   B . n 
B 2 243 THR 243 243 ?   ?   ?   B . n 
B 2 244 GLN 244 244 ?   ?   ?   B . n 
B 2 245 GLU 245 245 ?   ?   ?   B . n 
B 2 246 HIS 246 246 246 HIS HIS B . n 
B 2 247 PHE 247 247 247 PHE PHE B . n 
B 2 248 THR 248 248 248 THR THR B . n 
B 2 249 HIS 249 249 249 HIS HIS B . n 
B 2 250 ASN 250 250 250 ASN ASN B . n 
B 2 251 THR 251 251 251 THR THR B . n 
B 2 252 VAL 252 252 252 VAL VAL B . n 
B 2 253 ARG 253 253 253 ARG ARG B . n 
B 2 254 GLY 254 254 254 GLY GLY B . n 
B 2 255 CYS 255 255 255 CYS CYS B . n 
B 2 256 SER 256 256 256 SER SER B . n 
B 2 257 TYR 257 257 257 TYR TYR B . n 
B 2 258 PHE 258 258 258 PHE PHE B . n 
B 2 259 TYR 259 259 259 TYR TYR B . n 
B 2 260 SER 260 260 260 SER SER B . n 
B 2 261 TYR 261 261 261 TYR TYR B . n 
B 2 262 PRO 262 262 262 PRO PRO B . n 
B 2 263 ALA 263 263 263 ALA ALA B . n 
B 2 264 VAL 264 264 264 VAL VAL B . n 
B 2 265 CYS 265 265 265 CYS CYS B . n 
B 2 266 ASP 266 266 266 ASP ASP B . n 
B 2 267 PHE 267 267 267 PHE PHE B . n 
B 2 268 LEU 268 268 268 LEU LEU B . n 
B 2 269 GLN 269 269 269 GLN GLN B . n 
B 2 270 HIS 270 270 270 HIS HIS B . n 
B 2 271 ASN 271 271 271 ASN ASN B . n 
B 2 272 ASN 272 272 272 ASN ASN B . n 
B 2 273 LEU 273 273 273 LEU LEU B . n 
B 2 274 LEU 274 274 274 LEU LEU B . n 
B 2 275 SER 275 275 275 SER SER B . n 
B 2 276 ILE 276 276 276 ILE ILE B . n 
B 2 277 LEU 277 277 277 LEU LEU B . n 
B 2 278 ARG 278 278 278 ARG ARG B . n 
B 2 279 ALA 279 279 279 ALA ALA B . n 
B 2 280 HIS 280 280 280 HIS HIS B . n 
B 2 281 GLU 281 281 281 GLU GLU B . n 
B 2 282 ALA 282 282 282 ALA ALA B . n 
B 2 283 GLN 283 283 283 GLN GLN B . n 
B 2 284 ASP 284 284 284 ASP ASP B . n 
B 2 285 ALA 285 285 285 ALA ALA B . n 
B 2 286 GLY 286 286 286 GLY GLY B . n 
B 2 287 TYR 287 287 287 TYR TYR B . n 
B 2 288 ARG 288 288 288 ARG ARG B . n 
B 2 289 MET 289 289 289 MET MET B . n 
B 2 290 TYR 290 290 290 TYR TYR B . n 
B 2 291 ARG 291 291 291 ARG ARG B . n 
B 2 292 LYS 292 292 292 LYS LYS B . n 
B 2 293 SER 293 293 293 SER SER B . n 
B 2 294 GLN 294 294 294 GLN GLN B . n 
B 2 295 THR 295 295 295 THR THR B . n 
B 2 296 THR 296 296 296 THR THR B . n 
B 2 297 GLY 297 297 297 GLY GLY B . n 
B 2 298 PHE 298 298 298 PHE PHE B . n 
B 2 299 PRO 299 299 299 PRO PRO B . n 
B 2 300 SER 300 300 300 SER SER B . n 
B 2 301 LEU 301 301 301 LEU LEU B . n 
B 2 302 ILE 302 302 302 ILE ILE B . n 
B 2 303 THR 303 303 303 THR THR B . n 
B 2 304 ILE 304 304 304 ILE ILE B . n 
B 2 305 PHE 305 305 305 PHE PHE B . n 
B 2 306 SER 306 306 306 SER SER B . n 
B 2 307 ALA 307 307 307 ALA ALA B . n 
B 2 308 PRO 308 308 308 PRO PRO B . n 
B 2 309 ASN 309 309 309 ASN ASN B . n 
B 2 310 TYR 310 310 310 TYR TYR B . n 
B 2 311 LEU 311 311 311 LEU LEU B . n 
B 2 312 ASP 312 312 312 ASP ASP B . n 
B 2 313 VAL 313 313 313 VAL VAL B . n 
B 2 314 TYR 314 314 314 TYR TYR B . n 
B 2 315 ASN 315 315 315 ASN ASN B . n 
B 2 316 ASN 316 316 316 ASN ASN B . n 
B 2 317 LYS 317 317 317 LYS LYS B . n 
B 2 318 ALA 318 318 318 ALA ALA B . n 
B 2 319 ALA 319 319 319 ALA ALA B . n 
B 2 320 VAL 320 320 320 VAL VAL B . n 
B 2 321 LEU 321 321 321 LEU LEU B . n 
B 2 322 LYS 322 322 322 LYS LYS B . n 
B 2 323 TYR 323 323 323 TYR TYR B . n 
B 2 324 GLU 324 324 324 GLU GLU B . n 
B 2 325 ASN 325 325 325 ASN ASN B . n 
B 2 326 ASN 326 326 326 ASN ASN B . n 
B 2 327 VAL 327 327 327 VAL VAL B . n 
B 2 328 MET 328 328 328 MET MET B . n 
B 2 329 ASN 329 329 329 ASN ASN B . n 
B 2 330 ILE 330 330 330 ILE ILE B . n 
B 2 331 ARG 331 331 331 ARG ARG B . n 
B 2 332 GLN 332 332 332 GLN GLN B . n 
B 2 333 PHE 333 333 333 PHE PHE B . n 
B 2 334 ASN 334 334 334 ASN ASN B . n 
B 2 335 CYS 335 335 335 CYS CYS B . n 
B 2 336 SER 336 336 336 SER SER B . n 
B 2 337 PRO 337 337 337 PRO PRO B . n 
B 2 338 HIS 338 338 338 HIS HIS B . n 
B 2 339 PRO 339 339 339 PRO PRO B . n 
B 2 340 TYR 340 340 340 TYR TYR B . n 
B 2 341 TRP 341 341 341 TRP TRP B . n 
B 2 342 LEU 342 342 342 LEU LEU B . n 
B 2 343 PRO 343 343 343 PRO PRO B . n 
B 2 344 ASN 344 344 344 ASN ASN B . n 
B 2 345 PHE 345 345 345 PHE PHE B . n 
B 2 346 MET 346 346 346 MET MET B . n 
B 2 347 ASP 347 347 347 ASP ASP B . n 
B 2 348 VAL 348 348 348 VAL VAL B . n 
B 2 349 PHE 349 349 349 PHE PHE B . n 
B 2 350 THR 350 350 350 THR THR B . n 
B 2 351 TRP 351 351 351 TRP TRP B . n 
B 2 352 SER 352 352 352 SER SER B . n 
B 2 353 LEU 353 353 353 LEU LEU B . n 
B 2 354 PRO 354 354 354 PRO PRO B . n 
B 2 355 PHE 355 355 355 PHE PHE B . n 
B 2 356 VAL 356 356 356 VAL VAL B . n 
B 2 357 GLY 357 357 357 GLY GLY B . n 
B 2 358 GLU 358 358 358 GLU GLU B . n 
B 2 359 LYS 359 359 359 LYS LYS B . n 
B 2 360 VAL 360 360 360 VAL VAL B . n 
B 2 361 THR 361 361 361 THR THR B . n 
B 2 362 GLU 362 362 362 GLU GLU B . n 
B 2 363 MET 363 363 363 MET MET B . n 
B 2 364 LEU 364 364 364 LEU LEU B . n 
B 2 365 VAL 365 365 365 VAL VAL B . n 
B 2 366 ASN 366 366 366 ASN ASN B . n 
B 2 367 VAL 367 367 367 VAL VAL B . n 
B 2 368 LEU 368 368 368 LEU LEU B . n 
B 2 369 ASN 369 369 369 ASN ASN B . n 
B 2 370 ILE 370 370 ?   ?   ?   B . n 
C 3 1   MET 1   0   ?   ?   ?   C . n 
C 3 2   GLY 2   1   1   GLY GLY C . n 
C 3 3   VAL 3   2   2   VAL VAL C . n 
C 3 4   GLN 4   3   3   GLN GLN C . n 
C 3 5   VAL 5   4   4   VAL VAL C . n 
C 3 6   GLU 6   5   5   GLU GLU C . n 
C 3 7   THR 7   6   6   THR THR C . n 
C 3 8   ILE 8   7   7   ILE ILE C . n 
C 3 9   SER 9   8   8   SER SER C . n 
C 3 10  PRO 10  9   9   PRO PRO C . n 
C 3 11  GLY 11  10  10  GLY GLY C . n 
C 3 12  ASP 12  11  11  ASP ASP C . n 
C 3 13  GLY 13  12  12  GLY GLY C . n 
C 3 14  ARG 14  13  13  ARG ARG C . n 
C 3 15  THR 15  14  14  THR THR C . n 
C 3 16  PHE 16  15  15  PHE PHE C . n 
C 3 17  PRO 17  16  16  PRO PRO C . n 
C 3 18  LYS 18  17  17  LYS LYS C . n 
C 3 19  ARG 19  18  18  ARG ARG C . n 
C 3 20  GLY 20  19  19  GLY GLY C . n 
C 3 21  GLN 21  20  20  GLN GLN C . n 
C 3 22  THR 22  21  21  THR THR C . n 
C 3 23  CYS 23  22  22  CYS CYS C . n 
C 3 24  VAL 24  23  23  VAL VAL C . n 
C 3 25  VAL 25  24  24  VAL VAL C . n 
C 3 26  HIS 26  25  25  HIS HIS C . n 
C 3 27  TYR 27  26  26  TYR TYR C . n 
C 3 28  THR 28  27  27  THR THR C . n 
C 3 29  GLY 29  28  28  GLY GLY C . n 
C 3 30  MET 30  29  29  MET MET C . n 
C 3 31  LEU 31  30  30  LEU LEU C . n 
C 3 32  GLU 32  31  31  GLU GLU C . n 
C 3 33  ASP 33  32  32  ASP ASP C . n 
C 3 34  GLY 34  33  33  GLY GLY C . n 
C 3 35  LYS 35  34  34  LYS LYS C . n 
C 3 36  LYS 36  35  35  LYS LYS C . n 
C 3 37  PHE 37  36  36  PHE PHE C . n 
C 3 38  ASP 38  37  37  ASP ASP C . n 
C 3 39  SER 39  38  38  SER SER C . n 
C 3 40  SER 40  39  39  SER SER C . n 
C 3 41  ARG 41  40  40  ARG ARG C . n 
C 3 42  ASP 42  41  41  ASP ASP C . n 
C 3 43  ARG 43  42  42  ARG ARG C . n 
C 3 44  ASN 44  43  43  ASN ASN C . n 
C 3 45  LYS 45  44  44  LYS LYS C . n 
C 3 46  PRO 46  45  45  PRO PRO C . n 
C 3 47  PHE 47  46  46  PHE PHE C . n 
C 3 48  LYS 48  47  47  LYS LYS C . n 
C 3 49  PHE 49  48  48  PHE PHE C . n 
C 3 50  MET 50  49  49  MET MET C . n 
C 3 51  LEU 51  50  50  LEU LEU C . n 
C 3 52  GLY 52  51  51  GLY GLY C . n 
C 3 53  LYS 53  52  52  LYS LYS C . n 
C 3 54  GLN 54  53  53  GLN GLN C . n 
C 3 55  GLU 55  54  54  GLU GLU C . n 
C 3 56  VAL 56  55  55  VAL VAL C . n 
C 3 57  ILE 57  56  56  ILE ILE C . n 
C 3 58  ARG 58  57  57  ARG ARG C . n 
C 3 59  GLY 59  58  58  GLY GLY C . n 
C 3 60  TRP 60  59  59  TRP TRP C . n 
C 3 61  GLU 61  60  60  GLU GLU C . n 
C 3 62  GLU 62  61  61  GLU GLU C . n 
C 3 63  GLY 63  62  62  GLY GLY C . n 
C 3 64  VAL 64  63  63  VAL VAL C . n 
C 3 65  ALA 65  64  64  ALA ALA C . n 
C 3 66  GLN 66  65  65  GLN GLN C . n 
C 3 67  MET 67  66  66  MET MET C . n 
C 3 68  SER 68  67  67  SER SER C . n 
C 3 69  VAL 69  68  68  VAL VAL C . n 
C 3 70  GLY 70  69  69  GLY GLY C . n 
C 3 71  GLN 71  70  70  GLN GLN C . n 
C 3 72  ARG 72  71  71  ARG ARG C . n 
C 3 73  ALA 73  72  72  ALA ALA C . n 
C 3 74  LYS 74  73  73  LYS LYS C . n 
C 3 75  LEU 75  74  74  LEU LEU C . n 
C 3 76  THR 76  75  75  THR THR C . n 
C 3 77  ILE 77  76  76  ILE ILE C . n 
C 3 78  SER 78  77  77  SER SER C . n 
C 3 79  PRO 79  78  78  PRO PRO C . n 
C 3 80  ASP 80  79  79  ASP ASP C . n 
C 3 81  TYR 81  80  80  TYR TYR C . n 
C 3 82  ALA 82  81  81  ALA ALA C . n 
C 3 83  TYR 83  82  82  TYR TYR C . n 
C 3 84  GLY 84  83  83  GLY GLY C . n 
C 3 85  ALA 85  84  84  ALA ALA C . n 
C 3 86  THR 86  85  85  THR THR C . n 
C 3 87  GLY 87  86  86  GLY GLY C . n 
C 3 88  HIS 88  87  87  HIS HIS C . n 
C 3 89  PRO 89  88  88  PRO PRO C . n 
C 3 90  GLY 90  89  89  GLY GLY C . n 
C 3 91  ILE 91  90  90  ILE ILE C . n 
C 3 92  ILE 92  91  91  ILE ILE C . n 
C 3 93  PRO 93  92  92  PRO PRO C . n 
C 3 94  PRO 94  93  93  PRO PRO C . n 
C 3 95  HIS 95  94  94  HIS HIS C . n 
C 3 96  ALA 96  95  95  ALA ALA C . n 
C 3 97  THR 97  96  96  THR THR C . n 
C 3 98  LEU 98  97  97  LEU LEU C . n 
C 3 99  VAL 99  98  98  VAL VAL C . n 
C 3 100 PHE 100 99  99  PHE PHE C . n 
C 3 101 ASP 101 100 100 ASP ASP C . n 
C 3 102 VAL 102 101 101 VAL VAL C . n 
C 3 103 GLU 103 102 102 GLU GLU C . n 
C 3 104 LEU 104 103 103 LEU LEU C . n 
C 3 105 LEU 105 104 104 LEU LEU C . n 
C 3 106 LYS 106 105 105 LYS LYS C . n 
C 3 107 LEU 107 106 106 LEU LEU C . n 
C 3 108 GLU 108 107 107 GLU GLU C . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        FK5 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   FK5 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
D 4 CAU 1 501 501 CAU LIG A . 
E 5 FK5 1 201 108 FK5 FK5 C . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 288 ? CG  ? A LYS 260 CG  
2  1 Y 1 A LYS 288 ? CD  ? A LYS 260 CD  
3  1 Y 1 A LYS 288 ? CE  ? A LYS 260 CE  
4  1 Y 1 A LYS 288 ? NZ  ? A LYS 260 NZ  
5  1 Y 1 A LYS 300 ? CG  ? A LYS 272 CG  
6  1 Y 1 A LYS 300 ? CD  ? A LYS 272 CD  
7  1 Y 1 A LYS 300 ? CE  ? A LYS 272 CE  
8  1 Y 1 A LYS 300 ? NZ  ? A LYS 272 NZ  
9  1 Y 1 A ARG 427 ? CG  ? A ARG 399 CG  
10 1 Y 1 A ARG 427 ? CD  ? A ARG 399 CD  
11 1 Y 1 A ARG 427 ? NE  ? A ARG 399 NE  
12 1 Y 1 A ARG 427 ? CZ  ? A ARG 399 CZ  
13 1 Y 1 A ARG 427 ? NH1 ? A ARG 399 NH1 
14 1 Y 1 A ARG 427 ? NH2 ? A ARG 399 NH2 
15 1 Y 1 A GLU 461 ? CG  ? A GLU 433 CG  
16 1 Y 1 A GLU 461 ? CD  ? A GLU 433 CD  
17 1 Y 1 A GLU 461 ? OE1 ? A GLU 433 OE1 
18 1 Y 1 A GLU 461 ? OE2 ? A GLU 433 OE2 
19 1 Y 1 B LYS 31  ? CG  ? B LYS 31  CG  
20 1 Y 1 B LYS 31  ? CD  ? B LYS 31  CD  
21 1 Y 1 B LYS 31  ? CE  ? B LYS 31  CE  
22 1 Y 1 B LYS 31  ? NZ  ? B LYS 31  NZ  
23 1 Y 1 B ARG 41  ? CG  ? B ARG 41  CG  
24 1 Y 1 B ARG 41  ? CD  ? B ARG 41  CD  
25 1 Y 1 B ARG 41  ? NE  ? B ARG 41  NE  
26 1 Y 1 B ARG 41  ? CZ  ? B ARG 41  CZ  
27 1 Y 1 B ARG 41  ? NH1 ? B ARG 41  NH1 
28 1 Y 1 B ARG 41  ? NH2 ? B ARG 41  NH2 
29 1 Y 1 B GLU 56  ? CG  ? B GLU 56  CG  
30 1 Y 1 B GLU 56  ? CD  ? B GLU 56  CD  
31 1 Y 1 B GLU 56  ? OE1 ? B GLU 56  OE1 
32 1 Y 1 B GLU 56  ? OE2 ? B GLU 56  OE2 
33 1 Y 1 B GLU 157 ? CG  ? B GLU 157 CG  
34 1 Y 1 B GLU 157 ? CD  ? B GLU 157 CD  
35 1 Y 1 B GLU 157 ? OE1 ? B GLU 157 OE1 
36 1 Y 1 B GLU 157 ? OE2 ? B GLU 157 OE2 
37 1 Y 1 B GLN 192 ? CG  ? B GLN 192 CG  
38 1 Y 1 B GLN 192 ? CD  ? B GLN 192 CD  
39 1 Y 1 B GLN 192 ? OE1 ? B GLN 192 OE1 
40 1 Y 1 B GLN 192 ? NE2 ? B GLN 192 NE2 
41 1 Y 1 B ASP 209 ? CG  ? B ASP 209 CG  
42 1 Y 1 B ASP 209 ? OD1 ? B ASP 209 OD1 
43 1 Y 1 B ASP 209 ? OD2 ? B ASP 209 OD2 
44 1 Y 1 B ASP 210 ? CG  ? B ASP 210 CG  
45 1 Y 1 B ASP 210 ? OD1 ? B ASP 210 OD1 
46 1 Y 1 B ASP 210 ? OD2 ? B ASP 210 OD2 
47 1 Y 1 B ARG 216 ? CG  ? B ARG 216 CG  
48 1 Y 1 B ARG 216 ? CD  ? B ARG 216 CD  
49 1 Y 1 B ARG 216 ? NE  ? B ARG 216 NE  
50 1 Y 1 B ARG 216 ? CZ  ? B ARG 216 CZ  
51 1 Y 1 B ARG 216 ? NH1 ? B ARG 216 NH1 
52 1 Y 1 B ARG 216 ? NH2 ? B ARG 216 NH2 
53 1 Y 1 B ASP 228 ? CG  ? B ASP 228 CG  
54 1 Y 1 B ASP 228 ? OD1 ? B ASP 228 OD1 
55 1 Y 1 B ASP 228 ? OD2 ? B ASP 228 OD2 
56 1 Y 1 B PHE 247 ? CG  ? B PHE 247 CG  
57 1 Y 1 B PHE 247 ? CD1 ? B PHE 247 CD1 
58 1 Y 1 B PHE 247 ? CD2 ? B PHE 247 CD2 
59 1 Y 1 B PHE 247 ? CE1 ? B PHE 247 CE1 
60 1 Y 1 B PHE 247 ? CE2 ? B PHE 247 CE2 
61 1 Y 1 B PHE 247 ? CZ  ? B PHE 247 CZ  
62 1 Y 1 B GLU 324 ? CG  ? B GLU 324 CG  
63 1 Y 1 B GLU 324 ? CD  ? B GLU 324 CD  
64 1 Y 1 B GLU 324 ? OE1 ? B GLU 324 OE1 
65 1 Y 1 B GLU 324 ? OE2 ? B GLU 324 OE2 
66 1 Y 1 B ASN 334 ? CG  ? B ASN 334 CG  
67 1 Y 1 B ASN 334 ? OD1 ? B ASN 334 OD1 
68 1 Y 1 B ASN 334 ? ND2 ? B ASN 334 ND2 
69 1 Y 1 C ARG 13  ? CG  ? C ARG 14  CG  
70 1 Y 1 C ARG 13  ? CD  ? C ARG 14  CD  
71 1 Y 1 C ARG 13  ? NE  ? C ARG 14  NE  
72 1 Y 1 C ARG 13  ? CZ  ? C ARG 14  CZ  
73 1 Y 1 C ARG 13  ? NH1 ? C ARG 14  NH1 
74 1 Y 1 C ARG 13  ? NH2 ? C ARG 14  NH2 
75 1 Y 1 C MET 49  ? CG  ? C MET 50  CG  
76 1 Y 1 C MET 49  ? SD  ? C MET 50  SD  
77 1 Y 1 C MET 49  ? CE  ? C MET 50  CE  
78 1 Y 1 C ARG 57  ? CG  ? C ARG 58  CG  
79 1 Y 1 C ARG 57  ? CD  ? C ARG 58  CD  
80 1 Y 1 C ARG 57  ? NE  ? C ARG 58  NE  
81 1 Y 1 C ARG 57  ? CZ  ? C ARG 58  CZ  
82 1 Y 1 C ARG 57  ? NH1 ? C ARG 58  NH1 
83 1 Y 1 C ARG 57  ? NH2 ? C ARG 58  NH2 
84 1 Y 1 C GLU 60  ? CG  ? C GLU 61  CG  
85 1 Y 1 C GLU 60  ? CD  ? C GLU 61  CD  
86 1 Y 1 C GLU 60  ? OE1 ? C GLU 61  OE1 
87 1 Y 1 C GLU 60  ? OE2 ? C GLU 61  OE2 
88 1 Y 1 C GLU 102 ? CG  ? C GLU 103 CG  
89 1 Y 1 C GLU 102 ? CD  ? C GLU 103 CD  
90 1 Y 1 C GLU 102 ? OE1 ? C GLU 103 OE1 
91 1 Y 1 C GLU 102 ? OE2 ? C GLU 103 OE2 
92 1 Y 1 C GLU 107 ? O   ? C GLU 108 O   
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9CHX 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9CHX 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9CHX 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9CHX 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            . 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.003  ? 7305 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.622  ? 9912 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 12.833 ? 1003 ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.042  ? 1115 ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.003  ? 1248 ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9CHX 
_struct.title                        
'cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9CHX 
_struct_keywords.text            
'GPCR, cryo-EM, calcineurin fusion, inactive state, MEMBRANE PROTEIN, MEMBRANE PROTEIN-HYDROLASE-ISOMERASE complex' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN/HYDROLASE/ISOMERASE' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ADRB2_HUMAN P07550 ? 1 
;DEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEF
WTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANE
TCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQL
;
29  
2 UNP CANB1_HUMAN P63098 ? 1 
;DADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFA
FRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
;
16  
3 UNP ADRB2_HUMAN P07550 ? 1 
;KFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCL
RRSSLKAYGNGY
;
263 
4 UNP PP2BA_MOUSE P63328 ? 2 
;SEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQEKNLLDI
DAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFT
FKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGN
EKTQEHFTHNTVRGCSYFYSYPAVCDFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAV
LKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNI
;
2   
5 UNP FKB1A_HUMAN P62942 ? 3 
;MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPD
YAYGATGHPGIIPPHATLVFDVELLKLE
;
1   
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9CHX A 1   ? 202 ? P07550 29  ? 230 ? 29  230 
2 2 9CHX A 203 ? 357 ? P63098 16  ? 170 ? 231 385 
3 3 9CHX A 358 ? 449 ? P07550 263 ? 354 ? 386 477 
4 4 9CHX B 1   ? 370 ? P63328 2   ? 371 ? 1   370 
5 5 9CHX C 1   ? 108 ? P62942 1   ? 108 ? 0   107 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9CHX GLU A 159 ? UNP P07550 ASN 187 conflict 187 1 
3 9CHX ASP A 440 ? UNP P07550 SER 345 conflict 468 2 
3 9CHX ASP A 441 ? UNP P07550 SER 346 conflict 469 3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   trimeric 
_pdbx_struct_assembly.oligomeric_count     3 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 TRP A 4   ? LYS A 32  ? TRP A 32  LYS A 60  1 ? 29 
HELX_P HELX_P2  AA2 THR A 38  ? LYS A 69  ? THR A 66  LYS A 97  1 ? 32 
HELX_P HELX_P3  AA3 ASN A 75  ? SER A 109 ? ASN A 103 SER A 137 1 ? 35 
HELX_P HELX_P4  AA4 SER A 109 ? LEU A 117 ? SER A 137 LEU A 145 1 ? 9  
HELX_P HELX_P5  AA5 THR A 118 ? MET A 143 ? THR A 146 MET A 171 1 ? 26 
HELX_P HELX_P6  AA6 HIS A 150 ? ALA A 158 ? HIS A 178 ALA A 186 1 ? 9  
HELX_P HELX_P7  AA7 ASN A 168 ? PHE A 180 ? ASN A 196 PHE A 208 1 ? 13 
HELX_P HELX_P8  AA8 TYR A 181 ? ALA A 198 ? TYR A 209 ALA A 226 1 ? 18 
HELX_P HELX_P9  AA9 ARG A 200 ? ALA A 204 ? ARG A 228 ALA A 232 5 ? 5  
HELX_P HELX_P10 AB1 GLU A 206 ? ASP A 218 ? GLU A 234 ASP A 246 1 ? 13 
HELX_P HELX_P11 AB2 SER A 226 ? MET A 231 ? SER A 254 MET A 259 1 ? 6  
HELX_P HELX_P12 AB3 VAL A 242 ? ASP A 250 ? VAL A 270 ASP A 278 1 ? 9  
HELX_P HELX_P13 AB4 ASP A 258 ? SER A 267 ? ASP A 286 SER A 295 1 ? 10 
HELX_P HELX_P14 AB5 ASP A 274 ? ASP A 287 ? ASP A 302 ASP A 315 1 ? 14 
HELX_P HELX_P15 AB6 SER A 295 ? GLY A 308 ? SER A 323 GLY A 336 1 ? 14 
HELX_P HELX_P16 AB7 LYS A 312 ? ASP A 328 ? LYS A 340 ASP A 356 1 ? 17 
HELX_P HELX_P17 AB8 SER A 336 ? VAL A 344 ? SER A 364 VAL A 372 1 ? 9  
HELX_P HELX_P18 AB9 ALA A 366 ? ILE A 393 ? ALA A 394 ILE A 421 1 ? 28 
HELX_P HELX_P19 AC1 GLU A 401 ? PHE A 416 ? GLU A 429 PHE A 444 1 ? 16 
HELX_P HELX_P20 AC2 PHE A 416 ? CYS A 422 ? PHE A 444 CYS A 450 1 ? 7  
HELX_P HELX_P21 AC3 SER A 424 ? LEU A 435 ? SER A 452 LEU A 463 1 ? 12 
HELX_P HELX_P22 AC4 VAL B 42  ? MET B 50  ? VAL B 42  MET B 50  1 ? 9  
HELX_P HELX_P23 AC5 GLU B 56  ? GLN B 73  ? GLU B 56  GLN B 73  1 ? 18 
HELX_P HELX_P24 AC6 GLN B 93  ? GLY B 105 ? GLN B 93  GLY B 105 1 ? 13 
HELX_P HELX_P25 AC7 PHE B 124 ? TYR B 139 ? PHE B 124 TYR B 139 1 ? 16 
HELX_P HELX_P26 AC8 CYS B 152 ? PHE B 159 ? CYS B 152 PHE B 159 1 ? 8  
HELX_P HELX_P27 AC9 PHE B 161 ? TYR B 169 ? PHE B 161 TYR B 169 1 ? 9  
HELX_P HELX_P28 AD1 SER B 170 ? ASP B 182 ? SER B 170 ASP B 182 1 ? 13 
HELX_P HELX_P29 AD2 THR B 207 ? ARG B 212 ? THR B 207 ARG B 212 5 ? 6  
HELX_P HELX_P30 AD3 GLY B 224 ? LEU B 230 ? GLY B 224 LEU B 230 1 ? 7  
HELX_P HELX_P31 AD4 SER B 260 ? ASN B 271 ? SER B 260 ASN B 271 1 ? 12 
HELX_P HELX_P32 AD5 ASN B 309 ? VAL B 313 ? ASN B 309 VAL B 313 5 ? 5  
HELX_P HELX_P33 AD6 LEU B 342 ? MET B 346 ? LEU B 342 MET B 346 5 ? 5  
HELX_P HELX_P34 AD7 ASP B 347 ? LEU B 353 ? ASP B 347 LEU B 353 1 ? 7  
HELX_P HELX_P35 AD8 LEU B 353 ? ASN B 369 ? LEU B 353 ASN B 369 1 ? 17 
HELX_P HELX_P36 AD9 ILE C 57  ? ALA C 65  ? ILE C 56  ALA C 64  1 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ? ? A CYS 78  SG ? ? ? 1_555 A CYS 163 SG ? ? A CYS 106 A CYS 191 1_555 ? ? ? ? ? ? ? 2.031 ? ? 
disulf2 disulf ? ? A CYS 156 SG ? ? ? 1_555 A CYS 162 SG ? ? A CYS 184 A CYS 190 1_555 ? ? ? ? ? ? ? 2.033 ? ? 
# 
_struct_conn_type.id          disulf 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1 CYS A 78  ? CYS A 163 ? CYS A 106 ? 1_555 CYS A 191 ? 1_555 SG SG . . . None 'Disulfide bridge' 
2 CYS A 156 ? CYS A 162 ? CYS A 184 ? 1_555 CYS A 190 ? 1_555 SG SG . . . None 'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 6 ? 
AA2 ? 5 ? 
AA3 ? 4 ? 
AA4 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? anti-parallel 
AA2 1 2 ? parallel      
AA2 2 3 ? parallel      
AA2 3 4 ? anti-parallel 
AA2 4 5 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ASP B 79  ? ILE B 80  ? ASP B 79  ILE B 80  
AA1 2 LEU B 189 ? MET B 190 ? LEU B 189 MET B 190 
AA1 3 PHE B 194 ? CYS B 196 ? PHE B 194 CYS B 196 
AA1 4 SER B 275 ? ARG B 278 ? SER B 275 ARG B 278 
AA1 5 LEU B 301 ? ILE B 304 ? LEU B 301 ILE B 304 
AA1 6 TYR B 287 ? MET B 289 ? TYR B 287 MET B 289 
AA2 1 LEU B 143 ? LEU B 145 ? LEU B 143 LEU B 145 
AA2 2 TYR B 112 ? PHE B 114 ? TYR B 112 PHE B 114 
AA2 3 VAL B 84  ? CYS B 87  ? VAL B 84  CYS B 87  
AA2 4 ALA B 318 ? TYR B 323 ? ALA B 318 TYR B 323 
AA2 5 MET B 328 ? PHE B 333 ? MET B 328 PHE B 333 
AA3 1 VAL C 5   ? SER C 9   ? VAL C 4   SER C 8   
AA3 2 ARG C 72  ? ILE C 77  ? ARG C 71  ILE C 76  
AA3 3 LEU C 98  ? PHE C 100 ? LEU C 97  PHE C 99  
AA3 4 MET C 30  ? LEU C 31  ? MET C 29  LEU C 30  
AA4 1 PHE C 47  ? MET C 50  ? PHE C 46  MET C 49  
AA4 2 THR C 22  ? HIS C 26  ? THR C 21  HIS C 25  
AA4 3 GLU C 103 ? LEU C 107 ? GLU C 102 LEU C 106 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE B 80  ? N ILE B 80  O LEU B 189 ? O LEU B 189 
AA1 2 3 N MET B 190 ? N MET B 190 O PHE B 194 ? O PHE B 194 
AA1 3 4 N LEU B 195 ? N LEU B 195 O SER B 275 ? O SER B 275 
AA1 4 5 N ARG B 278 ? N ARG B 278 O ILE B 304 ? O ILE B 304 
AA1 5 6 O THR B 303 ? O THR B 303 N ARG B 288 ? N ARG B 288 
AA2 1 2 O PHE B 144 ? O PHE B 144 N PHE B 114 ? N PHE B 114 
AA2 2 3 O LEU B 113 ? O LEU B 113 N CYS B 87  ? N CYS B 87  
AA2 3 4 N VAL B 84  ? N VAL B 84  O TYR B 323 ? O TYR B 323 
AA2 4 5 N VAL B 320 ? N VAL B 320 O ARG B 331 ? O ARG B 331 
AA3 1 2 N SER C 9   ? N SER C 8   O ARG C 72  ? O ARG C 71  
AA3 2 3 N ILE C 77  ? N ILE C 76  O LEU C 98  ? O LEU C 97  
AA3 3 4 O VAL C 99  ? O VAL C 98  N MET C 30  ? N MET C 29  
AA4 1 2 O PHE C 47  ? O PHE C 46  N VAL C 25  ? N VAL C 24  
AA4 2 3 N VAL C 24  ? N VAL C 23  O LYS C 106 ? O LYS C 105 
# 
_pdbx_entry_details.entry_id                   9CHX 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OG B SER 293 ? ? O B PHE 298 ? ? 2.15 
2 1 OG A SER 323 ? ? O B THR 13  ? ? 2.17 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS A 97  ? ? 59.42   18.01   
2  1 ALA A 186 ? ? -92.15  52.18   
3  1 ASP A 233 ? ? 68.92   -3.81   
4  1 LYS A 318 ? ? 58.03   18.80   
5  1 ARG B 15  ? ? -161.68 116.34  
6  1 THR B 29  ? ? -94.52  52.59   
7  1 ALA B 30  ? ? 59.42   8.91    
8  1 THR B 160 ? ? -99.13  36.39   
9  1 TYR B 169 ? ? -125.05 -167.16 
10 1 ASN B 191 ? ? 58.77   13.79   
11 1 PHE B 217 ? ? -99.51  35.95   
12 1 ALA B 279 ? ? -140.57 44.01   
13 1 HIS B 280 ? ? -94.22  -60.21  
14 1 TYR B 290 ? ? -79.37  -166.03 
15 1 LEU B 311 ? ? 58.62   17.35   
16 1 ASN B 344 ? ? 58.20   19.93   
17 1 LEU C 30  ? ? -128.28 -169.41 
18 1 MET C 66  ? ? -79.40  -168.49 
19 1 TYR C 82  ? ? -67.23  6.65    
20 1 ILE C 90  ? ? -95.15  -66.42  
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9CHX 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9CHX 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.5 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               276093 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.5 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 'MULTIPLE SOURCES' COMPLEX 'calcineurin fused beta2AR in complex with FKBP12' ? ? ? 1,2,3 
2 1 RECOMBINANT        COMPLEX 'calcineurin fused beta2AR'                        ? ? ? 1     
3 1 RECOMBINANT        COMPLEX 'Protein phosphatase 3 catalytic subunit alpha'    ? ? ? 2     
4 1 RECOMBINANT        COMPLEX FKBP1A                                             ? ? ? 3     
# 
_em_imaging.entry_id                        9CHX 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'TFS KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               OTHER 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9CHX 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9CHX 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A ASP 29  ? A ASP 1   
2  1 Y 1 A GLU 30  ? A GLU 2   
3  1 Y 1 A VAL 31  ? A VAL 3   
4  1 Y 1 A CYS 464 ? A CYS 436 
5  1 Y 1 A LEU 465 ? A LEU 437 
6  1 Y 1 A ARG 466 ? A ARG 438 
7  1 Y 1 A ARG 467 ? A ARG 439 
8  1 Y 1 A ASP 468 ? A ASP 440 
9  1 Y 1 A ASP 469 ? A ASP 441 
10 1 Y 1 A LEU 470 ? A LEU 442 
11 1 Y 1 A LYS 471 ? A LYS 443 
12 1 Y 1 A ALA 472 ? A ALA 444 
13 1 Y 1 A TYR 473 ? A TYR 445 
14 1 Y 1 A GLY 474 ? A GLY 446 
15 1 Y 1 A ASN 475 ? A ASN 447 
16 1 Y 1 A GLY 476 ? A GLY 448 
17 1 Y 1 A TYR 477 ? A TYR 449 
18 1 Y 1 B SER 1   ? B SER 1   
19 1 Y 1 B GLU 2   ? B GLU 2   
20 1 Y 1 B PRO 3   ? B PRO 3   
21 1 Y 1 B LYS 4   ? B LYS 4   
22 1 Y 1 B ALA 5   ? B ALA 5   
23 1 Y 1 B ILE 6   ? B ILE 6   
24 1 Y 1 B ASP 7   ? B ASP 7   
25 1 Y 1 B PRO 8   ? B PRO 8   
26 1 Y 1 B LYS 9   ? B LYS 9   
27 1 Y 1 B LEU 10  ? B LEU 10  
28 1 Y 1 B SER 11  ? B SER 11  
29 1 Y 1 B THR 12  ? B THR 12  
30 1 Y 1 B ASN 36  ? B ASN 36  
31 1 Y 1 B ASP 37  ? B ASP 37  
32 1 Y 1 B GLU 241 ? B GLU 241 
33 1 Y 1 B LYS 242 ? B LYS 242 
34 1 Y 1 B THR 243 ? B THR 243 
35 1 Y 1 B GLN 244 ? B GLN 244 
36 1 Y 1 B GLU 245 ? B GLU 245 
37 1 Y 1 B ILE 370 ? B ILE 370 
38 1 Y 1 C MET 0   ? C MET 1   
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CAU O17  O N N 74  
CAU C16  C N S 75  
CAU C18  C N N 76  
CAU N19  N N N 77  
CAU C20  C N N 78  
CAU C21  C N N 79  
CAU C22  C N N 80  
CAU C15  C N N 81  
CAU O14  O N N 82  
CAU C13  C Y N 83  
CAU C12  C Y N 84  
CAU C11  C Y N 85  
CAU C10  C Y N 86  
CAU C8   C Y N 87  
CAU C9   C Y N 88  
CAU N7   N Y N 89  
CAU C3   C Y N 90  
CAU C4   C Y N 91  
CAU C2   C Y N 92  
CAU C1   C Y N 93  
CAU C6   C Y N 94  
CAU C5   C Y N 95  
CAU H17  H N N 96  
CAU H16  H N N 97  
CAU H181 H N N 98  
CAU H182 H N N 99  
CAU H191 H N N 100 
CAU H20  H N N 101 
CAU H211 H N N 102 
CAU H212 H N N 103 
CAU H213 H N N 104 
CAU H221 H N N 105 
CAU H222 H N N 106 
CAU H223 H N N 107 
CAU H151 H N N 108 
CAU H152 H N N 109 
CAU H12  H N N 110 
CAU H11  H N N 111 
CAU H10  H N N 112 
CAU H7   H N N 113 
CAU H2   H N N 114 
CAU H1   H N N 115 
CAU H6   H N N 116 
CAU H5   H N N 117 
CYS N    N N N 118 
CYS CA   C N R 119 
CYS C    C N N 120 
CYS O    O N N 121 
CYS CB   C N N 122 
CYS SG   S N N 123 
CYS OXT  O N N 124 
CYS H    H N N 125 
CYS H2   H N N 126 
CYS HA   H N N 127 
CYS HB2  H N N 128 
CYS HB3  H N N 129 
CYS HG   H N N 130 
CYS HXT  H N N 131 
FK5 C1   C N N 132 
FK5 C2   C N S 133 
FK5 C3   C N N 134 
FK5 C4   C N N 135 
FK5 C5   C N N 136 
FK5 C6   C N N 137 
FK5 C8   C N N 138 
FK5 C9   C N N 139 
FK5 C10  C N R 140 
FK5 C11  C N R 141 
FK5 C12  C N N 142 
FK5 C13  C N S 143 
FK5 C14  C N R 144 
FK5 C15  C N S 145 
FK5 C16  C N N 146 
FK5 C17  C N S 147 
FK5 C18  C N N 148 
FK5 C19  C N N 149 
FK5 C20  C N N 150 
FK5 C21  C N R 151 
FK5 C22  C N N 152 
FK5 C23  C N N 153 
FK5 C24  C N S 154 
FK5 C25  C N R 155 
FK5 C26  C N S 156 
FK5 C27  C N N 157 
FK5 C28  C N N 158 
FK5 C29  C N R 159 
FK5 C30  C N N 160 
FK5 C31  C N R 161 
FK5 C32  C N R 162 
FK5 C33  C N N 163 
FK5 C34  C N N 164 
FK5 C35  C N N 165 
FK5 C36  C N N 166 
FK5 C37  C N N 167 
FK5 C38  C N N 168 
FK5 C39  C N N 169 
FK5 C40  C N N 170 
FK5 C41  C N N 171 
FK5 C42  C N N 172 
FK5 C43  C N N 173 
FK5 C44  C N N 174 
FK5 C45  C N N 175 
FK5 N7   N N N 176 
FK5 O1   O N N 177 
FK5 O2   O N N 178 
FK5 O3   O N N 179 
FK5 O4   O N N 180 
FK5 O5   O N N 181 
FK5 O6   O N N 182 
FK5 O7   O N N 183 
FK5 O8   O N N 184 
FK5 O9   O N N 185 
FK5 O10  O N N 186 
FK5 O11  O N N 187 
FK5 O12  O N N 188 
FK5 H2   H N N 189 
FK5 H31A H N N 190 
FK5 H32A H N N 191 
FK5 H41  H N N 192 
FK5 H42  H N N 193 
FK5 H51  H N N 194 
FK5 H52  H N N 195 
FK5 H61  H N N 196 
FK5 H62  H N N 197 
FK5 H11  H N N 198 
FK5 H121 H N N 199 
FK5 H122 H N N 200 
FK5 H13  H N N 201 
FK5 H14  H N N 202 
FK5 H15  H N N 203 
FK5 H161 H N N 204 
FK5 H162 H N N 205 
FK5 H17  H N N 206 
FK5 H181 H N N 207 
FK5 H182 H N N 208 
FK5 H20  H N N 209 
FK5 H21  H N N 210 
FK5 H231 H N N 211 
FK5 H232 H N N 212 
FK5 H24  H N N 213 
FK5 H25  H N N 214 
FK5 H26  H N N 215 
FK5 H28  H N N 216 
FK5 H29  H N N 217 
FK5 H301 H N N 218 
FK5 H302 H N N 219 
FK5 H31  H N N 220 
FK5 H32  H N N 221 
FK5 H331 H N N 222 
FK5 H332 H N N 223 
FK5 H341 H N N 224 
FK5 H342 H N N 225 
FK5 H351 H N N 226 
FK5 H352 H N N 227 
FK5 H353 H N N 228 
FK5 H361 H N N 229 
FK5 H362 H N N 230 
FK5 H363 H N N 231 
FK5 H371 H N N 232 
FK5 H372 H N N 233 
FK5 H373 H N N 234 
FK5 H381 H N N 235 
FK5 H382 H N N 236 
FK5 H39  H N N 237 
FK5 H401 H N N 238 
FK5 H402 H N N 239 
FK5 H411 H N N 240 
FK5 H412 H N N 241 
FK5 H413 H N N 242 
FK5 H421 H N N 243 
FK5 H422 H N N 244 
FK5 H423 H N N 245 
FK5 H431 H N N 246 
FK5 H432 H N N 247 
FK5 H433 H N N 248 
FK5 H441 H N N 249 
FK5 H442 H N N 250 
FK5 H443 H N N 251 
FK5 H451 H N N 252 
FK5 H452 H N N 253 
FK5 H453 H N N 254 
FK5 HO6  H N N 255 
FK5 HO10 H N N 256 
FK5 HO12 H N N 257 
GLN N    N N N 258 
GLN CA   C N S 259 
GLN C    C N N 260 
GLN O    O N N 261 
GLN CB   C N N 262 
GLN CG   C N N 263 
GLN CD   C N N 264 
GLN OE1  O N N 265 
GLN NE2  N N N 266 
GLN OXT  O N N 267 
GLN H    H N N 268 
GLN H2   H N N 269 
GLN HA   H N N 270 
GLN HB2  H N N 271 
GLN HB3  H N N 272 
GLN HG2  H N N 273 
GLN HG3  H N N 274 
GLN HE21 H N N 275 
GLN HE22 H N N 276 
GLN HXT  H N N 277 
GLU N    N N N 278 
GLU CA   C N S 279 
GLU C    C N N 280 
GLU O    O N N 281 
GLU CB   C N N 282 
GLU CG   C N N 283 
GLU CD   C N N 284 
GLU OE1  O N N 285 
GLU OE2  O N N 286 
GLU OXT  O N N 287 
GLU H    H N N 288 
GLU H2   H N N 289 
GLU HA   H N N 290 
GLU HB2  H N N 291 
GLU HB3  H N N 292 
GLU HG2  H N N 293 
GLU HG3  H N N 294 
GLU HE2  H N N 295 
GLU HXT  H N N 296 
GLY N    N N N 297 
GLY CA   C N N 298 
GLY C    C N N 299 
GLY O    O N N 300 
GLY OXT  O N N 301 
GLY H    H N N 302 
GLY H2   H N N 303 
GLY HA2  H N N 304 
GLY HA3  H N N 305 
GLY HXT  H N N 306 
HIS N    N N N 307 
HIS CA   C N S 308 
HIS C    C N N 309 
HIS O    O N N 310 
HIS CB   C N N 311 
HIS CG   C Y N 312 
HIS ND1  N Y N 313 
HIS CD2  C Y N 314 
HIS CE1  C Y N 315 
HIS NE2  N Y N 316 
HIS OXT  O N N 317 
HIS H    H N N 318 
HIS H2   H N N 319 
HIS HA   H N N 320 
HIS HB2  H N N 321 
HIS HB3  H N N 322 
HIS HD1  H N N 323 
HIS HD2  H N N 324 
HIS HE1  H N N 325 
HIS HE2  H N N 326 
HIS HXT  H N N 327 
ILE N    N N N 328 
ILE CA   C N S 329 
ILE C    C N N 330 
ILE O    O N N 331 
ILE CB   C N S 332 
ILE CG1  C N N 333 
ILE CG2  C N N 334 
ILE CD1  C N N 335 
ILE OXT  O N N 336 
ILE H    H N N 337 
ILE H2   H N N 338 
ILE HA   H N N 339 
ILE HB   H N N 340 
ILE HG12 H N N 341 
ILE HG13 H N N 342 
ILE HG21 H N N 343 
ILE HG22 H N N 344 
ILE HG23 H N N 345 
ILE HD11 H N N 346 
ILE HD12 H N N 347 
ILE HD13 H N N 348 
ILE HXT  H N N 349 
LEU N    N N N 350 
LEU CA   C N S 351 
LEU C    C N N 352 
LEU O    O N N 353 
LEU CB   C N N 354 
LEU CG   C N N 355 
LEU CD1  C N N 356 
LEU CD2  C N N 357 
LEU OXT  O N N 358 
LEU H    H N N 359 
LEU H2   H N N 360 
LEU HA   H N N 361 
LEU HB2  H N N 362 
LEU HB3  H N N 363 
LEU HG   H N N 364 
LEU HD11 H N N 365 
LEU HD12 H N N 366 
LEU HD13 H N N 367 
LEU HD21 H N N 368 
LEU HD22 H N N 369 
LEU HD23 H N N 370 
LEU HXT  H N N 371 
LYS N    N N N 372 
LYS CA   C N S 373 
LYS C    C N N 374 
LYS O    O N N 375 
LYS CB   C N N 376 
LYS CG   C N N 377 
LYS CD   C N N 378 
LYS CE   C N N 379 
LYS NZ   N N N 380 
LYS OXT  O N N 381 
LYS H    H N N 382 
LYS H2   H N N 383 
LYS HA   H N N 384 
LYS HB2  H N N 385 
LYS HB3  H N N 386 
LYS HG2  H N N 387 
LYS HG3  H N N 388 
LYS HD2  H N N 389 
LYS HD3  H N N 390 
LYS HE2  H N N 391 
LYS HE3  H N N 392 
LYS HZ1  H N N 393 
LYS HZ2  H N N 394 
LYS HZ3  H N N 395 
LYS HXT  H N N 396 
MET N    N N N 397 
MET CA   C N S 398 
MET C    C N N 399 
MET O    O N N 400 
MET CB   C N N 401 
MET CG   C N N 402 
MET SD   S N N 403 
MET CE   C N N 404 
MET OXT  O N N 405 
MET H    H N N 406 
MET H2   H N N 407 
MET HA   H N N 408 
MET HB2  H N N 409 
MET HB3  H N N 410 
MET HG2  H N N 411 
MET HG3  H N N 412 
MET HE1  H N N 413 
MET HE2  H N N 414 
MET HE3  H N N 415 
MET HXT  H N N 416 
PHE N    N N N 417 
PHE CA   C N S 418 
PHE C    C N N 419 
PHE O    O N N 420 
PHE CB   C N N 421 
PHE CG   C Y N 422 
PHE CD1  C Y N 423 
PHE CD2  C Y N 424 
PHE CE1  C Y N 425 
PHE CE2  C Y N 426 
PHE CZ   C Y N 427 
PHE OXT  O N N 428 
PHE H    H N N 429 
PHE H2   H N N 430 
PHE HA   H N N 431 
PHE HB2  H N N 432 
PHE HB3  H N N 433 
PHE HD1  H N N 434 
PHE HD2  H N N 435 
PHE HE1  H N N 436 
PHE HE2  H N N 437 
PHE HZ   H N N 438 
PHE HXT  H N N 439 
PRO N    N N N 440 
PRO CA   C N S 441 
PRO C    C N N 442 
PRO O    O N N 443 
PRO CB   C N N 444 
PRO CG   C N N 445 
PRO CD   C N N 446 
PRO OXT  O N N 447 
PRO H    H N N 448 
PRO HA   H N N 449 
PRO HB2  H N N 450 
PRO HB3  H N N 451 
PRO HG2  H N N 452 
PRO HG3  H N N 453 
PRO HD2  H N N 454 
PRO HD3  H N N 455 
PRO HXT  H N N 456 
SER N    N N N 457 
SER CA   C N S 458 
SER C    C N N 459 
SER O    O N N 460 
SER CB   C N N 461 
SER OG   O N N 462 
SER OXT  O N N 463 
SER H    H N N 464 
SER H2   H N N 465 
SER HA   H N N 466 
SER HB2  H N N 467 
SER HB3  H N N 468 
SER HG   H N N 469 
SER HXT  H N N 470 
THR N    N N N 471 
THR CA   C N S 472 
THR C    C N N 473 
THR O    O N N 474 
THR CB   C N R 475 
THR OG1  O N N 476 
THR CG2  C N N 477 
THR OXT  O N N 478 
THR H    H N N 479 
THR H2   H N N 480 
THR HA   H N N 481 
THR HB   H N N 482 
THR HG1  H N N 483 
THR HG21 H N N 484 
THR HG22 H N N 485 
THR HG23 H N N 486 
THR HXT  H N N 487 
TRP N    N N N 488 
TRP CA   C N S 489 
TRP C    C N N 490 
TRP O    O N N 491 
TRP CB   C N N 492 
TRP CG   C Y N 493 
TRP CD1  C Y N 494 
TRP CD2  C Y N 495 
TRP NE1  N Y N 496 
TRP CE2  C Y N 497 
TRP CE3  C Y N 498 
TRP CZ2  C Y N 499 
TRP CZ3  C Y N 500 
TRP CH2  C Y N 501 
TRP OXT  O N N 502 
TRP H    H N N 503 
TRP H2   H N N 504 
TRP HA   H N N 505 
TRP HB2  H N N 506 
TRP HB3  H N N 507 
TRP HD1  H N N 508 
TRP HE1  H N N 509 
TRP HE3  H N N 510 
TRP HZ2  H N N 511 
TRP HZ3  H N N 512 
TRP HH2  H N N 513 
TRP HXT  H N N 514 
TYR N    N N N 515 
TYR CA   C N S 516 
TYR C    C N N 517 
TYR O    O N N 518 
TYR CB   C N N 519 
TYR CG   C Y N 520 
TYR CD1  C Y N 521 
TYR CD2  C Y N 522 
TYR CE1  C Y N 523 
TYR CE2  C Y N 524 
TYR CZ   C Y N 525 
TYR OH   O N N 526 
TYR OXT  O N N 527 
TYR H    H N N 528 
TYR H2   H N N 529 
TYR HA   H N N 530 
TYR HB2  H N N 531 
TYR HB3  H N N 532 
TYR HD1  H N N 533 
TYR HD2  H N N 534 
TYR HE1  H N N 535 
TYR HE2  H N N 536 
TYR HH   H N N 537 
TYR HXT  H N N 538 
VAL N    N N N 539 
VAL CA   C N S 540 
VAL C    C N N 541 
VAL O    O N N 542 
VAL CB   C N N 543 
VAL CG1  C N N 544 
VAL CG2  C N N 545 
VAL OXT  O N N 546 
VAL H    H N N 547 
VAL H2   H N N 548 
VAL HA   H N N 549 
VAL HB   H N N 550 
VAL HG11 H N N 551 
VAL HG12 H N N 552 
VAL HG13 H N N 553 
VAL HG21 H N N 554 
VAL HG22 H N N 555 
VAL HG23 H N N 556 
VAL HXT  H N N 557 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CAU C10 C11  doub Y N 70  
CAU C10 C8   sing Y N 71  
CAU C11 C12  sing Y N 72  
CAU C8  N7   sing Y N 73  
CAU C8  C9   doub Y N 74  
CAU N7  C3   sing Y N 75  
CAU C12 C13  doub Y N 76  
CAU C21 C20  sing N N 77  
CAU C9  C13  sing Y N 78  
CAU C9  C4   sing Y N 79  
CAU C13 O14  sing N N 80  
CAU C3  C4   doub Y N 81  
CAU C3  C2   sing Y N 82  
CAU C4  C5   sing Y N 83  
CAU C2  C1   doub Y N 84  
CAU O14 C15  sing N N 85  
CAU C18 N19  sing N N 86  
CAU C18 C16  sing N N 87  
CAU C15 C16  sing N N 88  
CAU C20 N19  sing N N 89  
CAU C20 C22  sing N N 90  
CAU C5  C6   doub Y N 91  
CAU C1  C6   sing Y N 92  
CAU C16 O17  sing N N 93  
CAU O17 H17  sing N N 94  
CAU C16 H16  sing N N 95  
CAU C18 H181 sing N N 96  
CAU C18 H182 sing N N 97  
CAU N19 H191 sing N N 98  
CAU C20 H20  sing N N 99  
CAU C21 H211 sing N N 100 
CAU C21 H212 sing N N 101 
CAU C21 H213 sing N N 102 
CAU C22 H221 sing N N 103 
CAU C22 H222 sing N N 104 
CAU C22 H223 sing N N 105 
CAU C15 H151 sing N N 106 
CAU C15 H152 sing N N 107 
CAU C12 H12  sing N N 108 
CAU C11 H11  sing N N 109 
CAU C10 H10  sing N N 110 
CAU N7  H7   sing N N 111 
CAU C2  H2   sing N N 112 
CAU C1  H1   sing N N 113 
CAU C6  H6   sing N N 114 
CAU C5  H5   sing N N 115 
CYS N   CA   sing N N 116 
CYS N   H    sing N N 117 
CYS N   H2   sing N N 118 
CYS CA  C    sing N N 119 
CYS CA  CB   sing N N 120 
CYS CA  HA   sing N N 121 
CYS C   O    doub N N 122 
CYS C   OXT  sing N N 123 
CYS CB  SG   sing N N 124 
CYS CB  HB2  sing N N 125 
CYS CB  HB3  sing N N 126 
CYS SG  HG   sing N N 127 
CYS OXT HXT  sing N N 128 
FK5 C1  C2   sing N N 129 
FK5 C1  O1   sing N N 130 
FK5 C1  O2   doub N N 131 
FK5 C2  C3   sing N N 132 
FK5 C2  N7   sing N N 133 
FK5 C2  H2   sing N N 134 
FK5 C3  C4   sing N N 135 
FK5 C3  H31A sing N N 136 
FK5 C3  H32A sing N N 137 
FK5 C4  C5   sing N N 138 
FK5 C4  H41  sing N N 139 
FK5 C4  H42  sing N N 140 
FK5 C5  C6   sing N N 141 
FK5 C5  H51  sing N N 142 
FK5 C5  H52  sing N N 143 
FK5 C6  N7   sing N N 144 
FK5 C6  H61  sing N N 145 
FK5 C6  H62  sing N N 146 
FK5 C8  C9   sing N N 147 
FK5 C8  N7   sing N N 148 
FK5 C8  O3   doub N N 149 
FK5 C9  C10  sing N N 150 
FK5 C9  O4   doub N N 151 
FK5 C10 C11  sing N N 152 
FK5 C10 O5   sing N N 153 
FK5 C10 O6   sing N N 154 
FK5 C11 C12  sing N N 155 
FK5 C11 C35  sing N N 156 
FK5 C11 H11  sing N N 157 
FK5 C12 C13  sing N N 158 
FK5 C12 H121 sing N N 159 
FK5 C12 H122 sing N N 160 
FK5 C13 C14  sing N N 161 
FK5 C13 O7   sing N N 162 
FK5 C13 H13  sing N N 163 
FK5 C14 C15  sing N N 164 
FK5 C14 O5   sing N N 165 
FK5 C14 H14  sing N N 166 
FK5 C15 C16  sing N N 167 
FK5 C15 O8   sing N N 168 
FK5 C15 H15  sing N N 169 
FK5 C16 C17  sing N N 170 
FK5 C16 H161 sing N N 171 
FK5 C16 H162 sing N N 172 
FK5 C17 C18  sing N N 173 
FK5 C17 C36  sing N N 174 
FK5 C17 H17  sing N N 175 
FK5 C18 C19  sing N N 176 
FK5 C18 H181 sing N N 177 
FK5 C18 H182 sing N N 178 
FK5 C19 C20  doub N E 179 
FK5 C19 C37  sing N N 180 
FK5 C20 C21  sing N N 181 
FK5 C20 H20  sing N N 182 
FK5 C21 C22  sing N N 183 
FK5 C21 C38  sing N N 184 
FK5 C21 H21  sing N N 185 
FK5 C22 C23  sing N N 186 
FK5 C22 O9   doub N N 187 
FK5 C23 C24  sing N N 188 
FK5 C23 H231 sing N N 189 
FK5 C23 H232 sing N N 190 
FK5 C24 C25  sing N N 191 
FK5 C24 O10  sing N N 192 
FK5 C24 H24  sing N N 193 
FK5 C25 C26  sing N N 194 
FK5 C25 C41  sing N N 195 
FK5 C25 H25  sing N N 196 
FK5 C26 C27  sing N N 197 
FK5 C26 O1   sing N N 198 
FK5 C26 H26  sing N N 199 
FK5 C27 C28  doub N E 200 
FK5 C27 C42  sing N N 201 
FK5 C28 C29  sing N N 202 
FK5 C28 H28  sing N N 203 
FK5 C29 C30  sing N N 204 
FK5 C29 C34  sing N N 205 
FK5 C29 H29  sing N N 206 
FK5 C30 C31  sing N N 207 
FK5 C30 H301 sing N N 208 
FK5 C30 H302 sing N N 209 
FK5 C31 C32  sing N N 210 
FK5 C31 O11  sing N N 211 
FK5 C31 H31  sing N N 212 
FK5 C32 C33  sing N N 213 
FK5 C32 O12  sing N N 214 
FK5 C32 H32  sing N N 215 
FK5 C33 C34  sing N N 216 
FK5 C33 H331 sing N N 217 
FK5 C33 H332 sing N N 218 
FK5 C34 H341 sing N N 219 
FK5 C34 H342 sing N N 220 
FK5 C35 H351 sing N N 221 
FK5 C35 H352 sing N N 222 
FK5 C35 H353 sing N N 223 
FK5 C36 H361 sing N N 224 
FK5 C36 H362 sing N N 225 
FK5 C36 H363 sing N N 226 
FK5 C37 H371 sing N N 227 
FK5 C37 H372 sing N N 228 
FK5 C37 H373 sing N N 229 
FK5 C38 C39  sing N N 230 
FK5 C38 H381 sing N N 231 
FK5 C38 H382 sing N N 232 
FK5 C39 C40  doub N N 233 
FK5 C39 H39  sing N N 234 
FK5 C40 H401 sing N N 235 
FK5 C40 H402 sing N N 236 
FK5 C41 H411 sing N N 237 
FK5 C41 H412 sing N N 238 
FK5 C41 H413 sing N N 239 
FK5 C42 H421 sing N N 240 
FK5 C42 H422 sing N N 241 
FK5 C42 H423 sing N N 242 
FK5 C43 O7   sing N N 243 
FK5 C43 H431 sing N N 244 
FK5 C43 H432 sing N N 245 
FK5 C43 H433 sing N N 246 
FK5 C44 O8   sing N N 247 
FK5 C44 H441 sing N N 248 
FK5 C44 H442 sing N N 249 
FK5 C44 H443 sing N N 250 
FK5 C45 O11  sing N N 251 
FK5 C45 H451 sing N N 252 
FK5 C45 H452 sing N N 253 
FK5 C45 H453 sing N N 254 
FK5 O6  HO6  sing N N 255 
FK5 O10 HO10 sing N N 256 
FK5 O12 HO12 sing N N 257 
GLN N   CA   sing N N 258 
GLN N   H    sing N N 259 
GLN N   H2   sing N N 260 
GLN CA  C    sing N N 261 
GLN CA  CB   sing N N 262 
GLN CA  HA   sing N N 263 
GLN C   O    doub N N 264 
GLN C   OXT  sing N N 265 
GLN CB  CG   sing N N 266 
GLN CB  HB2  sing N N 267 
GLN CB  HB3  sing N N 268 
GLN CG  CD   sing N N 269 
GLN CG  HG2  sing N N 270 
GLN CG  HG3  sing N N 271 
GLN CD  OE1  doub N N 272 
GLN CD  NE2  sing N N 273 
GLN NE2 HE21 sing N N 274 
GLN NE2 HE22 sing N N 275 
GLN OXT HXT  sing N N 276 
GLU N   CA   sing N N 277 
GLU N   H    sing N N 278 
GLU N   H2   sing N N 279 
GLU CA  C    sing N N 280 
GLU CA  CB   sing N N 281 
GLU CA  HA   sing N N 282 
GLU C   O    doub N N 283 
GLU C   OXT  sing N N 284 
GLU CB  CG   sing N N 285 
GLU CB  HB2  sing N N 286 
GLU CB  HB3  sing N N 287 
GLU CG  CD   sing N N 288 
GLU CG  HG2  sing N N 289 
GLU CG  HG3  sing N N 290 
GLU CD  OE1  doub N N 291 
GLU CD  OE2  sing N N 292 
GLU OE2 HE2  sing N N 293 
GLU OXT HXT  sing N N 294 
GLY N   CA   sing N N 295 
GLY N   H    sing N N 296 
GLY N   H2   sing N N 297 
GLY CA  C    sing N N 298 
GLY CA  HA2  sing N N 299 
GLY CA  HA3  sing N N 300 
GLY C   O    doub N N 301 
GLY C   OXT  sing N N 302 
GLY OXT HXT  sing N N 303 
HIS N   CA   sing N N 304 
HIS N   H    sing N N 305 
HIS N   H2   sing N N 306 
HIS CA  C    sing N N 307 
HIS CA  CB   sing N N 308 
HIS CA  HA   sing N N 309 
HIS C   O    doub N N 310 
HIS C   OXT  sing N N 311 
HIS CB  CG   sing N N 312 
HIS CB  HB2  sing N N 313 
HIS CB  HB3  sing N N 314 
HIS CG  ND1  sing Y N 315 
HIS CG  CD2  doub Y N 316 
HIS ND1 CE1  doub Y N 317 
HIS ND1 HD1  sing N N 318 
HIS CD2 NE2  sing Y N 319 
HIS CD2 HD2  sing N N 320 
HIS CE1 NE2  sing Y N 321 
HIS CE1 HE1  sing N N 322 
HIS NE2 HE2  sing N N 323 
HIS OXT HXT  sing N N 324 
ILE N   CA   sing N N 325 
ILE N   H    sing N N 326 
ILE N   H2   sing N N 327 
ILE CA  C    sing N N 328 
ILE CA  CB   sing N N 329 
ILE CA  HA   sing N N 330 
ILE C   O    doub N N 331 
ILE C   OXT  sing N N 332 
ILE CB  CG1  sing N N 333 
ILE CB  CG2  sing N N 334 
ILE CB  HB   sing N N 335 
ILE CG1 CD1  sing N N 336 
ILE CG1 HG12 sing N N 337 
ILE CG1 HG13 sing N N 338 
ILE CG2 HG21 sing N N 339 
ILE CG2 HG22 sing N N 340 
ILE CG2 HG23 sing N N 341 
ILE CD1 HD11 sing N N 342 
ILE CD1 HD12 sing N N 343 
ILE CD1 HD13 sing N N 344 
ILE OXT HXT  sing N N 345 
LEU N   CA   sing N N 346 
LEU N   H    sing N N 347 
LEU N   H2   sing N N 348 
LEU CA  C    sing N N 349 
LEU CA  CB   sing N N 350 
LEU CA  HA   sing N N 351 
LEU C   O    doub N N 352 
LEU C   OXT  sing N N 353 
LEU CB  CG   sing N N 354 
LEU CB  HB2  sing N N 355 
LEU CB  HB3  sing N N 356 
LEU CG  CD1  sing N N 357 
LEU CG  CD2  sing N N 358 
LEU CG  HG   sing N N 359 
LEU CD1 HD11 sing N N 360 
LEU CD1 HD12 sing N N 361 
LEU CD1 HD13 sing N N 362 
LEU CD2 HD21 sing N N 363 
LEU CD2 HD22 sing N N 364 
LEU CD2 HD23 sing N N 365 
LEU OXT HXT  sing N N 366 
LYS N   CA   sing N N 367 
LYS N   H    sing N N 368 
LYS N   H2   sing N N 369 
LYS CA  C    sing N N 370 
LYS CA  CB   sing N N 371 
LYS CA  HA   sing N N 372 
LYS C   O    doub N N 373 
LYS C   OXT  sing N N 374 
LYS CB  CG   sing N N 375 
LYS CB  HB2  sing N N 376 
LYS CB  HB3  sing N N 377 
LYS CG  CD   sing N N 378 
LYS CG  HG2  sing N N 379 
LYS CG  HG3  sing N N 380 
LYS CD  CE   sing N N 381 
LYS CD  HD2  sing N N 382 
LYS CD  HD3  sing N N 383 
LYS CE  NZ   sing N N 384 
LYS CE  HE2  sing N N 385 
LYS CE  HE3  sing N N 386 
LYS NZ  HZ1  sing N N 387 
LYS NZ  HZ2  sing N N 388 
LYS NZ  HZ3  sing N N 389 
LYS OXT HXT  sing N N 390 
MET N   CA   sing N N 391 
MET N   H    sing N N 392 
MET N   H2   sing N N 393 
MET CA  C    sing N N 394 
MET CA  CB   sing N N 395 
MET CA  HA   sing N N 396 
MET C   O    doub N N 397 
MET C   OXT  sing N N 398 
MET CB  CG   sing N N 399 
MET CB  HB2  sing N N 400 
MET CB  HB3  sing N N 401 
MET CG  SD   sing N N 402 
MET CG  HG2  sing N N 403 
MET CG  HG3  sing N N 404 
MET SD  CE   sing N N 405 
MET CE  HE1  sing N N 406 
MET CE  HE2  sing N N 407 
MET CE  HE3  sing N N 408 
MET OXT HXT  sing N N 409 
PHE N   CA   sing N N 410 
PHE N   H    sing N N 411 
PHE N   H2   sing N N 412 
PHE CA  C    sing N N 413 
PHE CA  CB   sing N N 414 
PHE CA  HA   sing N N 415 
PHE C   O    doub N N 416 
PHE C   OXT  sing N N 417 
PHE CB  CG   sing N N 418 
PHE CB  HB2  sing N N 419 
PHE CB  HB3  sing N N 420 
PHE CG  CD1  doub Y N 421 
PHE CG  CD2  sing Y N 422 
PHE CD1 CE1  sing Y N 423 
PHE CD1 HD1  sing N N 424 
PHE CD2 CE2  doub Y N 425 
PHE CD2 HD2  sing N N 426 
PHE CE1 CZ   doub Y N 427 
PHE CE1 HE1  sing N N 428 
PHE CE2 CZ   sing Y N 429 
PHE CE2 HE2  sing N N 430 
PHE CZ  HZ   sing N N 431 
PHE OXT HXT  sing N N 432 
PRO N   CA   sing N N 433 
PRO N   CD   sing N N 434 
PRO N   H    sing N N 435 
PRO CA  C    sing N N 436 
PRO CA  CB   sing N N 437 
PRO CA  HA   sing N N 438 
PRO C   O    doub N N 439 
PRO C   OXT  sing N N 440 
PRO CB  CG   sing N N 441 
PRO CB  HB2  sing N N 442 
PRO CB  HB3  sing N N 443 
PRO CG  CD   sing N N 444 
PRO CG  HG2  sing N N 445 
PRO CG  HG3  sing N N 446 
PRO CD  HD2  sing N N 447 
PRO CD  HD3  sing N N 448 
PRO OXT HXT  sing N N 449 
SER N   CA   sing N N 450 
SER N   H    sing N N 451 
SER N   H2   sing N N 452 
SER CA  C    sing N N 453 
SER CA  CB   sing N N 454 
SER CA  HA   sing N N 455 
SER C   O    doub N N 456 
SER C   OXT  sing N N 457 
SER CB  OG   sing N N 458 
SER CB  HB2  sing N N 459 
SER CB  HB3  sing N N 460 
SER OG  HG   sing N N 461 
SER OXT HXT  sing N N 462 
THR N   CA   sing N N 463 
THR N   H    sing N N 464 
THR N   H2   sing N N 465 
THR CA  C    sing N N 466 
THR CA  CB   sing N N 467 
THR CA  HA   sing N N 468 
THR C   O    doub N N 469 
THR C   OXT  sing N N 470 
THR CB  OG1  sing N N 471 
THR CB  CG2  sing N N 472 
THR CB  HB   sing N N 473 
THR OG1 HG1  sing N N 474 
THR CG2 HG21 sing N N 475 
THR CG2 HG22 sing N N 476 
THR CG2 HG23 sing N N 477 
THR OXT HXT  sing N N 478 
TRP N   CA   sing N N 479 
TRP N   H    sing N N 480 
TRP N   H2   sing N N 481 
TRP CA  C    sing N N 482 
TRP CA  CB   sing N N 483 
TRP CA  HA   sing N N 484 
TRP C   O    doub N N 485 
TRP C   OXT  sing N N 486 
TRP CB  CG   sing N N 487 
TRP CB  HB2  sing N N 488 
TRP CB  HB3  sing N N 489 
TRP CG  CD1  doub Y N 490 
TRP CG  CD2  sing Y N 491 
TRP CD1 NE1  sing Y N 492 
TRP CD1 HD1  sing N N 493 
TRP CD2 CE2  doub Y N 494 
TRP CD2 CE3  sing Y N 495 
TRP NE1 CE2  sing Y N 496 
TRP NE1 HE1  sing N N 497 
TRP CE2 CZ2  sing Y N 498 
TRP CE3 CZ3  doub Y N 499 
TRP CE3 HE3  sing N N 500 
TRP CZ2 CH2  doub Y N 501 
TRP CZ2 HZ2  sing N N 502 
TRP CZ3 CH2  sing Y N 503 
TRP CZ3 HZ3  sing N N 504 
TRP CH2 HH2  sing N N 505 
TRP OXT HXT  sing N N 506 
TYR N   CA   sing N N 507 
TYR N   H    sing N N 508 
TYR N   H2   sing N N 509 
TYR CA  C    sing N N 510 
TYR CA  CB   sing N N 511 
TYR CA  HA   sing N N 512 
TYR C   O    doub N N 513 
TYR C   OXT  sing N N 514 
TYR CB  CG   sing N N 515 
TYR CB  HB2  sing N N 516 
TYR CB  HB3  sing N N 517 
TYR CG  CD1  doub Y N 518 
TYR CG  CD2  sing Y N 519 
TYR CD1 CE1  sing Y N 520 
TYR CD1 HD1  sing N N 521 
TYR CD2 CE2  doub Y N 522 
TYR CD2 HD2  sing N N 523 
TYR CE1 CZ   doub Y N 524 
TYR CE1 HE1  sing N N 525 
TYR CE2 CZ   sing Y N 526 
TYR CE2 HE2  sing N N 527 
TYR CZ  OH   sing N N 528 
TYR OH  HH   sing N N 529 
TYR OXT HXT  sing N N 530 
VAL N   CA   sing N N 531 
VAL N   H    sing N N 532 
VAL N   H2   sing N N 533 
VAL CA  C    sing N N 534 
VAL CA  CB   sing N N 535 
VAL CA  HA   sing N N 536 
VAL C   O    doub N N 537 
VAL C   OXT  sing N N 538 
VAL CB  CG1  sing N N 539 
VAL CB  CG2  sing N N 540 
VAL CB  HB   sing N N 541 
VAL CG1 HG11 sing N N 542 
VAL CG1 HG12 sing N N 543 
VAL CG1 HG13 sing N N 544 
VAL CG2 HG21 sing N N 545 
VAL CG2 HG22 sing N N 546 
VAL CG2 HG23 sing N N 547 
VAL OXT HXT  sing N N 548 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-07-02 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9CHX 
_em_admin.last_update        2024-11-27 
_em_admin.map_release_date   2024-11-13 
_em_admin.title              'cryo-EM structure of calcineurin-fused beta2 adrenergic receptor in carazolol bound inactive state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
loop_
_em_entity_assembly_naturalsource.cell 
_em_entity_assembly_naturalsource.cellular_location 
_em_entity_assembly_naturalsource.entity_assembly_id 
_em_entity_assembly_naturalsource.id 
_em_entity_assembly_naturalsource.ncbi_tax_id 
_em_entity_assembly_naturalsource.organism 
_em_entity_assembly_naturalsource.organelle 
_em_entity_assembly_naturalsource.organ 
_em_entity_assembly_naturalsource.strain 
_em_entity_assembly_naturalsource.tissue 
_em_entity_assembly_naturalsource.details 
? ? 2 2 9606  'Homo sapiens' ? ? ? ? ? 
? ? 3 3 10090 'Mus musculus' ? ? ? ? ? 
? ? 4 4 9606  'Homo sapiens' ? ? ? ? ? 
# 
loop_
_em_entity_assembly_recombinant.cell 
_em_entity_assembly_recombinant.entity_assembly_id 
_em_entity_assembly_recombinant.id 
_em_entity_assembly_recombinant.ncbi_tax_id 
_em_entity_assembly_recombinant.organism 
_em_entity_assembly_recombinant.plasmid 
_em_entity_assembly_recombinant.strain 
? 2 2 7108 'Spodoptera frugiperda' ? ? 
? 3 3 7108 'Spodoptera frugiperda' ? ? 
? 4 4 562  'Escherichia coli'      ? ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         48 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K2 QUANTUM (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?      ?          
'MODEL REFINEMENT'              ? 2  ? ? ? PHENIX 1.18_3861: 
'IMAGE ACQUISITION'             ? 3  ? ? 1 ?      ?          
MASKING                         ? 4  ? ? ? ?      ?          
'CTF CORRECTION'                ? 5  1 ? ? ?      ?          
'LAYERLINE INDEXING'            ? 6  ? ? ? ?      ?          
'DIFFRACTION INDEXING'          ? 7  ? ? ? ?      ?          
'MODEL FITTING'                 ? 8  ? ? ? ?      ?          
OTHER                           ? 9  ? ? ? ?      ?          
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?      ?          
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?      ?          
CLASSIFICATION                  ? 12 1 ? ? ?      ?          
RECONSTRUCTION                  ? 13 1 ? ? ?      ?          
'VOLUME SELECTION'              ? 14 1 1 1 ?      ?          
'SERIES ALIGNMENT'              ? 15 1 1 1 ?      ?          
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?      ?          
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?      ?          
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?      ?          
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?      ?          
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9CHX 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . TRP A 1 4   ? 160.945 146.646 173.650 1.00 23.98 ? 32  TRP A N   1 
ATOM   2    C CA  . TRP A 1 4   ? 160.854 148.047 174.039 1.00 23.98 ? 32  TRP A CA  1 
ATOM   3    C C   . TRP A 1 4   ? 159.795 148.740 173.184 1.00 23.98 ? 32  TRP A C   1 
ATOM   4    O O   . TRP A 1 4   ? 159.111 148.089 172.394 1.00 23.98 ? 32  TRP A O   1 
ATOM   5    C CB  . TRP A 1 4   ? 162.219 148.728 173.903 1.00 23.98 ? 32  TRP A CB  1 
ATOM   6    C CG  . TRP A 1 4   ? 162.369 149.979 174.722 1.00 23.98 ? 32  TRP A CG  1 
ATOM   7    C CD1 . TRP A 1 4   ? 162.206 150.097 176.071 1.00 23.98 ? 32  TRP A CD1 1 
ATOM   8    C CD2 . TRP A 1 4   ? 162.757 151.276 174.250 1.00 23.98 ? 32  TRP A CD2 1 
ATOM   9    N NE1 . TRP A 1 4   ? 162.443 151.391 176.465 1.00 23.98 ? 32  TRP A NE1 1 
ATOM   10   C CE2 . TRP A 1 4   ? 162.786 152.134 175.367 1.00 23.98 ? 32  TRP A CE2 1 
ATOM   11   C CE3 . TRP A 1 4   ? 163.073 151.796 172.991 1.00 23.98 ? 32  TRP A CE3 1 
ATOM   12   C CZ2 . TRP A 1 4   ? 163.118 153.484 175.263 1.00 23.98 ? 32  TRP A CZ2 1 
ATOM   13   C CZ3 . TRP A 1 4   ? 163.402 153.137 172.891 1.00 23.98 ? 32  TRP A CZ3 1 
ATOM   14   C CH2 . TRP A 1 4   ? 163.421 153.964 174.019 1.00 23.98 ? 32  TRP A CH2 1 
ATOM   15   N N   . VAL A 1 5   ? 159.658 150.058 173.346 1.00 22.29 ? 33  VAL A N   1 
ATOM   16   C CA  . VAL A 1 5   ? 158.590 150.782 172.660 1.00 22.29 ? 33  VAL A CA  1 
ATOM   17   C C   . VAL A 1 5   ? 158.811 150.775 171.152 1.00 22.29 ? 33  VAL A C   1 
ATOM   18   O O   . VAL A 1 5   ? 157.853 150.707 170.371 1.00 22.29 ? 33  VAL A O   1 
ATOM   19   C CB  . VAL A 1 5   ? 158.468 152.213 173.218 1.00 22.29 ? 33  VAL A CB  1 
ATOM   20   C CG1 . VAL A 1 5   ? 158.104 152.171 174.693 1.00 22.29 ? 33  VAL A CG1 1 
ATOM   21   C CG2 . VAL A 1 5   ? 159.758 152.988 173.014 1.00 22.29 ? 33  VAL A CG2 1 
ATOM   22   N N   . VAL A 1 6   ? 160.072 150.842 170.718 1.00 21.48 ? 34  VAL A N   1 
ATOM   23   C CA  . VAL A 1 6   ? 160.368 150.847 169.286 1.00 21.48 ? 34  VAL A CA  1 
ATOM   24   C C   . VAL A 1 6   ? 159.916 149.541 168.647 1.00 21.48 ? 34  VAL A C   1 
ATOM   25   O O   . VAL A 1 6   ? 159.270 149.534 167.591 1.00 21.48 ? 34  VAL A O   1 
ATOM   26   C CB  . VAL A 1 6   ? 161.867 151.102 169.048 1.00 21.48 ? 34  VAL A CB  1 
ATOM   27   C CG1 . VAL A 1 6   ? 162.202 150.965 167.570 1.00 21.48 ? 34  VAL A CG1 1 
ATOM   28   C CG2 . VAL A 1 6   ? 162.257 152.479 169.558 1.00 21.48 ? 34  VAL A CG2 1 
ATOM   29   N N   . GLY A 1 7   ? 160.238 148.415 169.286 1.00 20.64 ? 35  GLY A N   1 
ATOM   30   C CA  . GLY A 1 7   ? 159.845 147.128 168.737 1.00 20.64 ? 35  GLY A CA  1 
ATOM   31   C C   . GLY A 1 7   ? 158.340 146.964 168.665 1.00 20.64 ? 35  GLY A C   1 
ATOM   32   O O   . GLY A 1 7   ? 157.801 146.496 167.660 1.00 20.64 ? 35  GLY A O   1 
ATOM   33   N N   . MET A 1 8   ? 157.640 147.351 169.733 1.00 21.09 ? 36  MET A N   1 
ATOM   34   C CA  . MET A 1 8   ? 156.186 147.228 169.749 1.00 21.09 ? 36  MET A CA  1 
ATOM   35   C C   . MET A 1 8   ? 155.549 148.109 168.682 1.00 21.09 ? 36  MET A C   1 
ATOM   36   O O   . MET A 1 8   ? 154.614 147.685 167.990 1.00 21.09 ? 36  MET A O   1 
ATOM   37   C CB  . MET A 1 8   ? 155.648 147.588 171.136 1.00 21.09 ? 36  MET A CB  1 
ATOM   38   C CG  . MET A 1 8   ? 155.795 146.488 172.187 1.00 21.09 ? 36  MET A CG  1 
ATOM   39   S SD  . MET A 1 8   ? 154.880 144.940 171.971 1.00 21.09 ? 36  MET A SD  1 
ATOM   40   C CE  . MET A 1 8   ? 153.529 145.410 170.893 1.00 21.09 ? 36  MET A CE  1 
ATOM   41   N N   . GLY A 1 9   ? 156.042 149.341 168.534 1.00 18.81 ? 37  GLY A N   1 
ATOM   42   C CA  . GLY A 1 9   ? 155.526 150.210 167.491 1.00 18.81 ? 37  GLY A CA  1 
ATOM   43   C C   . GLY A 1 9   ? 155.768 149.654 166.103 1.00 18.81 ? 37  GLY A C   1 
ATOM   44   O O   . GLY A 1 9   ? 154.900 149.734 165.230 1.00 18.81 ? 37  GLY A O   1 
ATOM   45   N N   . ILE A 1 10  ? 156.951 149.075 165.881 1.00 19.73 ? 38  ILE A N   1 
ATOM   46   C CA  . ILE A 1 10  ? 157.251 148.470 164.587 1.00 19.73 ? 38  ILE A CA  1 
ATOM   47   C C   . ILE A 1 10  ? 156.313 147.301 164.315 1.00 19.73 ? 38  ILE A C   1 
ATOM   48   O O   . ILE A 1 10  ? 155.807 147.140 163.197 1.00 19.73 ? 38  ILE A O   1 
ATOM   49   C CB  . ILE A 1 10  ? 158.731 148.044 164.531 1.00 19.73 ? 38  ILE A CB  1 
ATOM   50   C CG1 . ILE A 1 10  ? 159.635 149.276 164.438 1.00 19.73 ? 38  ILE A CG1 1 
ATOM   51   C CG2 . ILE A 1 10  ? 158.982 147.116 163.354 1.00 19.73 ? 38  ILE A CG2 1 
ATOM   52   C CD1 . ILE A 1 10  ? 159.440 150.087 163.177 1.00 19.73 ? 38  ILE A CD1 1 
ATOM   53   N N   . VAL A 1 11  ? 156.065 146.469 165.330 1.00 19.09 ? 39  VAL A N   1 
ATOM   54   C CA  . VAL A 1 11  ? 155.159 145.334 165.159 1.00 19.09 ? 39  VAL A CA  1 
ATOM   55   C C   . VAL A 1 11  ? 153.759 145.817 164.802 1.00 19.09 ? 39  VAL A C   1 
ATOM   56   O O   . VAL A 1 11  ? 153.117 145.289 163.885 1.00 19.09 ? 39  VAL A O   1 
ATOM   57   C CB  . VAL A 1 11  ? 155.147 144.453 166.421 1.00 19.09 ? 39  VAL A CB  1 
ATOM   58   C CG1 . VAL A 1 11  ? 154.123 143.343 166.278 1.00 19.09 ? 39  VAL A CG1 1 
ATOM   59   C CG2 . VAL A 1 11  ? 156.518 143.848 166.654 1.00 19.09 ? 39  VAL A CG2 1 
ATOM   60   N N   . MET A 1 12  ? 153.264 146.830 165.518 1.00 19.74 ? 40  MET A N   1 
ATOM   61   C CA  . MET A 1 12  ? 151.927 147.343 165.232 1.00 19.74 ? 40  MET A CA  1 
ATOM   62   C C   . MET A 1 12  ? 151.844 147.935 163.830 1.00 19.74 ? 40  MET A C   1 
ATOM   63   O O   . MET A 1 12  ? 150.865 147.704 163.105 1.00 19.74 ? 40  MET A O   1 
ATOM   64   C CB  . MET A 1 12  ? 151.525 148.384 166.276 1.00 19.74 ? 40  MET A CB  1 
ATOM   65   C CG  . MET A 1 12  ? 151.374 147.825 167.676 1.00 19.74 ? 40  MET A CG  1 
ATOM   66   S SD  . MET A 1 12  ? 150.036 146.622 167.752 1.00 19.74 ? 40  MET A SD  1 
ATOM   67   C CE  . MET A 1 12  ? 150.241 145.976 169.408 1.00 19.74 ? 40  MET A CE  1 
ATOM   68   N N   . SER A 1 13  ? 152.861 148.705 163.432 1.00 17.60 ? 41  SER A N   1 
ATOM   69   C CA  . SER A 1 13  ? 152.857 149.306 162.103 1.00 17.60 ? 41  SER A CA  1 
ATOM   70   C C   . SER A 1 13  ? 152.872 148.238 161.019 1.00 17.60 ? 41  SER A C   1 
ATOM   71   O O   . SER A 1 13  ? 152.123 148.326 160.039 1.00 17.60 ? 41  SER A O   1 
ATOM   72   C CB  . SER A 1 13  ? 154.054 150.244 161.950 1.00 17.60 ? 41  SER A CB  1 
ATOM   73   O OG  . SER A 1 13  ? 153.969 151.327 162.859 1.00 17.60 ? 41  SER A OG  1 
ATOM   74   N N   . LEU A 1 14  ? 153.712 147.214 161.184 1.00 20.02 ? 42  LEU A N   1 
ATOM   75   C CA  . LEU A 1 14  ? 153.758 146.133 160.206 1.00 20.02 ? 42  LEU A CA  1 
ATOM   76   C C   . LEU A 1 14  ? 152.426 145.399 160.140 1.00 20.02 ? 42  LEU A C   1 
ATOM   77   O O   . LEU A 1 14  ? 151.949 145.063 159.050 1.00 20.02 ? 42  LEU A O   1 
ATOM   78   C CB  . LEU A 1 14  ? 154.890 145.165 160.548 1.00 20.02 ? 42  LEU A CB  1 
ATOM   79   C CG  . LEU A 1 14  ? 155.422 144.311 159.396 1.00 20.02 ? 42  LEU A CG  1 
ATOM   80   C CD1 . LEU A 1 14  ? 155.840 145.192 158.228 1.00 20.02 ? 42  LEU A CD1 1 
ATOM   81   C CD2 . LEU A 1 14  ? 156.580 143.437 159.858 1.00 20.02 ? 42  LEU A CD2 1 
ATOM   82   N N   . ILE A 1 15  ? 151.803 145.156 161.296 1.00 17.89 ? 43  ILE A N   1 
ATOM   83   C CA  . ILE A 1 15  ? 150.530 144.441 161.325 1.00 17.89 ? 43  ILE A CA  1 
ATOM   84   C C   . ILE A 1 15  ? 149.463 145.219 160.567 1.00 17.89 ? 43  ILE A C   1 
ATOM   85   O O   . ILE A 1 15  ? 148.767 144.670 159.702 1.00 17.89 ? 43  ILE A O   1 
ATOM   86   C CB  . ILE A 1 15  ? 150.102 144.166 162.778 1.00 17.89 ? 43  ILE A CB  1 
ATOM   87   C CG1 . ILE A 1 15  ? 150.863 142.966 163.342 1.00 17.89 ? 43  ILE A CG1 1 
ATOM   88   C CG2 . ILE A 1 15  ? 148.602 143.934 162.864 1.00 17.89 ? 43  ILE A CG2 1 
ATOM   89   C CD1 . ILE A 1 15  ? 150.595 142.712 164.807 1.00 17.89 ? 43  ILE A CD1 1 
ATOM   90   N N   . VAL A 1 16  ? 149.326 146.514 160.867 1.00 16.96 ? 44  VAL A N   1 
ATOM   91   C CA  . VAL A 1 16  ? 148.265 147.287 160.226 1.00 16.96 ? 44  VAL A CA  1 
ATOM   92   C C   . VAL A 1 16  ? 148.547 147.455 158.736 1.00 16.96 ? 44  VAL A C   1 
ATOM   93   O O   . VAL A 1 16  ? 147.632 147.369 157.905 1.00 16.96 ? 44  VAL A O   1 
ATOM   94   C CB  . VAL A 1 16  ? 148.063 148.642 160.933 1.00 16.96 ? 44  VAL A CB  1 
ATOM   95   C CG1 . VAL A 1 16  ? 149.337 149.463 160.933 1.00 16.96 ? 44  VAL A CG1 1 
ATOM   96   C CG2 . VAL A 1 16  ? 146.928 149.415 160.276 1.00 16.96 ? 44  VAL A CG2 1 
ATOM   97   N N   . LEU A 1 17  ? 149.813 147.671 158.366 1.00 16.88 ? 45  LEU A N   1 
ATOM   98   C CA  . LEU A 1 17  ? 150.146 147.815 156.955 1.00 16.88 ? 45  LEU A CA  1 
ATOM   99   C C   . LEU A 1 17  ? 149.853 146.533 156.186 1.00 16.88 ? 45  LEU A C   1 
ATOM   100  O O   . LEU A 1 17  ? 149.296 146.577 155.083 1.00 16.88 ? 45  LEU A O   1 
ATOM   101  C CB  . LEU A 1 17  ? 151.614 148.215 156.803 1.00 16.88 ? 45  LEU A CB  1 
ATOM   102  C CG  . LEU A 1 17  ? 152.041 148.762 155.441 1.00 16.88 ? 45  LEU A CG  1 
ATOM   103  C CD1 . LEU A 1 17  ? 151.302 150.052 155.126 1.00 16.88 ? 45  LEU A CD1 1 
ATOM   104  C CD2 . LEU A 1 17  ? 153.543 148.982 155.406 1.00 16.88 ? 45  LEU A CD2 1 
ATOM   105  N N   . ALA A 1 18  ? 150.212 145.379 156.756 1.00 16.13 ? 46  ALA A N   1 
ATOM   106  C CA  . ALA A 1 18  ? 149.940 144.110 156.091 1.00 16.13 ? 46  ALA A CA  1 
ATOM   107  C C   . ALA A 1 18  ? 148.444 143.868 155.959 1.00 16.13 ? 46  ALA A C   1 
ATOM   108  O O   . ALA A 1 18  ? 147.973 143.413 154.909 1.00 16.13 ? 46  ALA A O   1 
ATOM   109  C CB  . ALA A 1 18  ? 150.607 142.965 156.851 1.00 16.13 ? 46  ALA A CB  1 
ATOM   110  N N   . ILE A 1 19  ? 147.680 144.166 157.014 1.00 16.59 ? 47  ILE A N   1 
ATOM   111  C CA  . ILE A 1 19  ? 146.230 144.001 156.947 1.00 16.59 ? 47  ILE A CA  1 
ATOM   112  C C   . ILE A 1 19  ? 145.657 144.834 155.809 1.00 16.59 ? 47  ILE A C   1 
ATOM   113  O O   . ILE A 1 19  ? 144.902 144.334 154.963 1.00 16.59 ? 47  ILE A O   1 
ATOM   114  C CB  . ILE A 1 19  ? 145.583 144.376 158.293 1.00 16.59 ? 47  ILE A CB  1 
ATOM   115  C CG1 . ILE A 1 19  ? 145.864 143.302 159.344 1.00 16.59 ? 47  ILE A CG1 1 
ATOM   116  C CG2 . ILE A 1 19  ? 144.089 144.599 158.126 1.00 16.59 ? 47  ILE A CG2 1 
ATOM   117  C CD1 . ILE A 1 19  ? 145.395 143.674 160.732 1.00 16.59 ? 47  ILE A CD1 1 
ATOM   118  N N   . VAL A 1 20  ? 146.031 146.116 155.759 1.00 16.22 ? 48  VAL A N   1 
ATOM   119  C CA  . VAL A 1 20  ? 145.487 147.007 154.739 1.00 16.22 ? 48  VAL A CA  1 
ATOM   120  C C   . VAL A 1 20  ? 145.882 146.533 153.347 1.00 16.22 ? 48  VAL A C   1 
ATOM   121  O O   . VAL A 1 20  ? 145.046 146.475 152.439 1.00 16.22 ? 48  VAL A O   1 
ATOM   122  C CB  . VAL A 1 20  ? 145.944 148.455 154.991 1.00 16.22 ? 48  VAL A CB  1 
ATOM   123  C CG1 . VAL A 1 20  ? 145.495 149.356 153.852 1.00 16.22 ? 48  VAL A CG1 1 
ATOM   124  C CG2 . VAL A 1 20  ? 145.401 148.954 156.314 1.00 16.22 ? 48  VAL A CG2 1 
ATOM   125  N N   . PHE A 1 21  ? 147.153 146.172 153.159 1.00 17.17 ? 49  PHE A N   1 
ATOM   126  C CA  . PHE A 1 21  ? 147.631 145.793 151.833 1.00 17.17 ? 49  PHE A CA  1 
ATOM   127  C C   . PHE A 1 21  ? 146.951 144.519 151.343 1.00 17.17 ? 49  PHE A C   1 
ATOM   128  O O   . PHE A 1 21  ? 146.464 144.458 150.205 1.00 17.17 ? 49  PHE A O   1 
ATOM   129  C CB  . PHE A 1 21  ? 149.152 145.633 151.863 1.00 17.17 ? 49  PHE A CB  1 
ATOM   130  C CG  . PHE A 1 21  ? 149.762 145.321 150.527 1.00 17.17 ? 49  PHE A CG  1 
ATOM   131  C CD1 . PHE A 1 21  ? 149.800 146.278 149.528 1.00 17.17 ? 49  PHE A CD1 1 
ATOM   132  C CD2 . PHE A 1 21  ? 150.329 144.082 150.282 1.00 17.17 ? 49  PHE A CD2 1 
ATOM   133  C CE1 . PHE A 1 21  ? 150.369 145.996 148.300 1.00 17.17 ? 49  PHE A CE1 1 
ATOM   134  C CE2 . PHE A 1 21  ? 150.903 143.796 149.058 1.00 17.17 ? 49  PHE A CE2 1 
ATOM   135  C CZ  . PHE A 1 21  ? 150.922 144.754 148.065 1.00 17.17 ? 49  PHE A CZ  1 
ATOM   136  N N   . GLY A 1 22  ? 146.893 143.493 152.196 1.00 14.30 ? 50  GLY A N   1 
ATOM   137  C CA  . GLY A 1 22  ? 146.247 142.253 151.798 1.00 14.30 ? 50  GLY A CA  1 
ATOM   138  C C   . GLY A 1 22  ? 144.771 142.430 151.502 1.00 14.30 ? 50  GLY A C   1 
ATOM   139  O O   . GLY A 1 22  ? 144.259 141.906 150.506 1.00 14.30 ? 50  GLY A O   1 
ATOM   140  N N   . ASN A 1 23  ? 144.063 143.179 152.352 1.00 14.84 ? 51  ASN A N   1 
ATOM   141  C CA  . ASN A 1 23  ? 142.637 143.359 152.117 1.00 14.84 ? 51  ASN A CA  1 
ATOM   142  C C   . ASN A 1 23  ? 142.371 144.203 150.878 1.00 14.84 ? 51  ASN A C   1 
ATOM   143  O O   . ASN A 1 23  ? 141.405 143.941 150.154 1.00 14.84 ? 51  ASN A O   1 
ATOM   144  C CB  . ASN A 1 23  ? 141.976 143.970 153.348 1.00 14.84 ? 51  ASN A CB  1 
ATOM   145  C CG  . ASN A 1 23  ? 141.753 142.952 154.442 1.00 14.84 ? 51  ASN A CG  1 
ATOM   146  O OD1 . ASN A 1 23  ? 141.057 141.956 154.245 1.00 14.84 ? 51  ASN A OD1 1 
ATOM   147  N ND2 . ASN A 1 23  ? 142.347 143.191 155.604 1.00 14.84 ? 51  ASN A ND2 1 
ATOM   148  N N   . VAL A 1 24  ? 143.210 145.206 150.607 1.00 15.16 ? 52  VAL A N   1 
ATOM   149  C CA  . VAL A 1 24  ? 143.057 145.980 149.379 1.00 15.16 ? 52  VAL A CA  1 
ATOM   150  C C   . VAL A 1 24  ? 143.280 145.095 148.161 1.00 15.16 ? 52  VAL A C   1 
ATOM   151  O O   . VAL A 1 24  ? 142.546 145.188 147.169 1.00 15.16 ? 52  VAL A O   1 
ATOM   152  C CB  . VAL A 1 24  ? 144.002 147.196 149.385 1.00 15.16 ? 52  VAL A CB  1 
ATOM   153  C CG1 . VAL A 1 24  ? 144.054 147.834 148.008 1.00 15.16 ? 52  VAL A CG1 1 
ATOM   154  C CG2 . VAL A 1 24  ? 143.528 148.219 150.399 1.00 15.16 ? 52  VAL A CG2 1 
ATOM   155  N N   . LEU A 1 25  ? 144.289 144.220 148.213 1.00 14.68 ? 53  LEU A N   1 
ATOM   156  C CA  . LEU A 1 25  ? 144.506 143.295 147.104 1.00 14.68 ? 53  LEU A CA  1 
ATOM   157  C C   . LEU A 1 25  ? 143.289 142.403 146.888 1.00 14.68 ? 53  LEU A C   1 
ATOM   158  O O   . LEU A 1 25  ? 142.843 142.202 145.751 1.00 14.68 ? 53  LEU A O   1 
ATOM   159  C CB  . LEU A 1 25  ? 145.750 142.444 147.357 1.00 14.68 ? 53  LEU A CB  1 
ATOM   160  C CG  . LEU A 1 25  ? 147.108 143.069 147.048 1.00 14.68 ? 53  LEU A CG  1 
ATOM   161  C CD1 . LEU A 1 25  ? 148.220 142.135 147.486 1.00 14.68 ? 53  LEU A CD1 1 
ATOM   162  C CD2 . LEU A 1 25  ? 147.223 143.384 145.568 1.00 14.68 ? 53  LEU A CD2 1 
ATOM   163  N N   . VAL A 1 26  ? 142.734 141.862 147.976 1.00 14.97 ? 54  VAL A N   1 
ATOM   164  C CA  . VAL A 1 26  ? 141.583 140.969 147.853 1.00 14.97 ? 54  VAL A CA  1 
ATOM   165  C C   . VAL A 1 26  ? 140.387 141.710 147.270 1.00 14.97 ? 54  VAL A C   1 
ATOM   166  O O   . VAL A 1 26  ? 139.682 141.190 146.396 1.00 14.97 ? 54  VAL A O   1 
ATOM   167  C CB  . VAL A 1 26  ? 141.246 140.331 149.214 1.00 14.97 ? 54  VAL A CB  1 
ATOM   168  C CG1 . VAL A 1 26  ? 139.854 139.725 149.187 1.00 14.97 ? 54  VAL A CG1 1 
ATOM   169  C CG2 . VAL A 1 26  ? 142.272 139.274 149.563 1.00 14.97 ? 54  VAL A CG2 1 
ATOM   170  N N   . ILE A 1 27  ? 140.138 142.934 147.738 1.00 14.57 ? 55  ILE A N   1 
ATOM   171  C CA  . ILE A 1 27  ? 139.001 143.701 147.237 1.00 14.57 ? 55  ILE A CA  1 
ATOM   172  C C   . ILE A 1 27  ? 139.191 144.043 145.764 1.00 14.57 ? 55  ILE A C   1 
ATOM   173  O O   . ILE A 1 27  ? 138.246 143.970 144.970 1.00 14.57 ? 55  ILE A O   1 
ATOM   174  C CB  . ILE A 1 27  ? 138.790 144.963 148.092 1.00 14.57 ? 55  ILE A CB  1 
ATOM   175  C CG1 . ILE A 1 27  ? 138.444 144.579 149.530 1.00 14.57 ? 55  ILE A CG1 1 
ATOM   176  C CG2 . ILE A 1 27  ? 137.680 145.821 147.510 1.00 14.57 ? 55  ILE A CG2 1 
ATOM   177  C CD1 . ILE A 1 27  ? 138.474 145.739 150.493 1.00 14.57 ? 55  ILE A CD1 1 
ATOM   178  N N   . THR A 1 28  ? 140.411 144.420 145.374 1.00 15.26 ? 56  THR A N   1 
ATOM   179  C CA  . THR A 1 28  ? 140.666 144.785 143.983 1.00 15.26 ? 56  THR A CA  1 
ATOM   180  C C   . THR A 1 28  ? 140.532 143.581 143.057 1.00 15.26 ? 56  THR A C   1 
ATOM   181  O O   . THR A 1 28  ? 140.044 143.714 141.927 1.00 15.26 ? 56  THR A O   1 
ATOM   182  C CB  . THR A 1 28  ? 142.055 145.415 143.855 1.00 15.26 ? 56  THR A CB  1 
ATOM   183  O OG1 . THR A 1 28  ? 142.140 146.564 144.707 1.00 15.26 ? 56  THR A OG1 1 
ATOM   184  C CG2 . THR A 1 28  ? 142.326 145.839 142.419 1.00 15.26 ? 56  THR A CG2 1 
ATOM   185  N N   . ALA A 1 29  ? 140.947 142.396 143.517 1.00 15.70 ? 57  ALA A N   1 
ATOM   186  C CA  . ALA A 1 29  ? 140.887 141.210 142.667 1.00 15.70 ? 57  ALA A CA  1 
ATOM   187  C C   . ALA A 1 29  ? 139.463 140.852 142.258 1.00 15.70 ? 57  ALA A C   1 
ATOM   188  O O   . ALA A 1 29  ? 139.274 140.192 141.231 1.00 15.70 ? 57  ALA A O   1 
ATOM   189  C CB  . ALA A 1 29  ? 141.538 140.022 143.375 1.00 15.70 ? 57  ALA A CB  1 
ATOM   190  N N   . ILE A 1 30  ? 138.461 141.268 143.031 1.00 14.67 ? 58  ILE A N   1 
ATOM   191  C CA  . ILE A 1 30  ? 137.061 141.016 142.711 1.00 14.67 ? 58  ILE A CA  1 
ATOM   192  C C   . ILE A 1 30  ? 136.349 142.271 142.229 1.00 14.67 ? 58  ILE A C   1 
ATOM   193  O O   . ILE A 1 30  ? 135.153 142.213 141.905 1.00 14.67 ? 58  ILE A O   1 
ATOM   194  C CB  . ILE A 1 30  ? 136.322 140.399 143.915 1.00 14.67 ? 58  ILE A CB  1 
ATOM   195  C CG1 . ILE A 1 30  ? 137.205 139.355 144.596 1.00 14.67 ? 58  ILE A CG1 1 
ATOM   196  C CG2 . ILE A 1 30  ? 135.037 139.709 143.487 1.00 14.67 ? 58  ILE A CG2 1 
ATOM   197  C CD1 . ILE A 1 30  ? 136.605 138.782 145.857 1.00 14.67 ? 58  ILE A CD1 1 
ATOM   198  N N   . ALA A 1 31  ? 137.049 143.402 142.147 1.00 16.82 ? 59  ALA A N   1 
ATOM   199  C CA  . ALA A 1 31  ? 136.405 144.650 141.753 1.00 16.82 ? 59  ALA A CA  1 
ATOM   200  C C   . ALA A 1 31  ? 136.158 144.702 140.248 1.00 16.82 ? 59  ALA A C   1 
ATOM   201  O O   . ALA A 1 31  ? 135.011 144.795 139.799 1.00 16.82 ? 59  ALA A O   1 
ATOM   202  C CB  . ALA A 1 31  ? 137.253 145.842 142.202 1.00 16.82 ? 59  ALA A CB  1 
ATOM   203  N N   . LYS A 1 32  ? 137.225 144.639 139.453 1.00 18.50 ? 60  LYS A N   1 
ATOM   204  C CA  . LYS A 1 32  ? 137.119 144.754 138.005 1.00 18.50 ? 60  LYS A CA  1 
ATOM   205  C C   . LYS A 1 32  ? 137.500 143.489 137.253 1.00 18.50 ? 60  LYS A C   1 
ATOM   206  O O   . LYS A 1 32  ? 136.893 143.205 136.218 1.00 18.50 ? 60  LYS A O   1 
ATOM   207  C CB  . LYS A 1 32  ? 137.990 145.913 137.495 1.00 18.50 ? 60  LYS A CB  1 
ATOM   208  C CG  . LYS A 1 32  ? 137.745 147.233 138.209 1.00 18.50 ? 60  LYS A CG  1 
ATOM   209  C CD  . LYS A 1 32  ? 136.356 147.772 137.904 1.00 18.50 ? 60  LYS A CD  1 
ATOM   210  C CE  . LYS A 1 32  ? 136.058 149.028 138.708 1.00 18.50 ? 60  LYS A CE  1 
ATOM   211  N NZ  . LYS A 1 32  ? 136.970 150.148 138.347 1.00 18.50 ? 60  LYS A NZ  1 
ATOM   212  N N   . PHE A 1 33  ? 138.478 142.722 137.737 1.00 20.22 ? 61  PHE A N   1 
ATOM   213  C CA  . PHE A 1 33  ? 138.872 141.466 137.097 1.00 20.22 ? 61  PHE A CA  1 
ATOM   214  C C   . PHE A 1 33  ? 137.817 140.405 137.411 1.00 20.22 ? 61  PHE A C   1 
ATOM   215  O O   . PHE A 1 33  ? 138.064 139.402 138.082 1.00 20.22 ? 61  PHE A O   1 
ATOM   216  C CB  . PHE A 1 33  ? 140.254 141.039 137.568 1.00 20.22 ? 61  PHE A CB  1 
ATOM   217  C CG  . PHE A 1 33  ? 141.356 141.956 137.125 1.00 20.22 ? 61  PHE A CG  1 
ATOM   218  C CD1 . PHE A 1 33  ? 141.883 141.864 135.848 1.00 20.22 ? 61  PHE A CD1 1 
ATOM   219  C CD2 . PHE A 1 33  ? 141.862 142.916 137.985 1.00 20.22 ? 61  PHE A CD2 1 
ATOM   220  C CE1 . PHE A 1 33  ? 142.897 142.709 135.439 1.00 20.22 ? 61  PHE A CE1 1 
ATOM   221  C CE2 . PHE A 1 33  ? 142.875 143.764 137.583 1.00 20.22 ? 61  PHE A CE2 1 
ATOM   222  C CZ  . PHE A 1 33  ? 143.393 143.661 136.308 1.00 20.22 ? 61  PHE A CZ  1 
ATOM   223  N N   . GLU A 1 34  ? 136.613 140.642 136.890 1.00 16.81 ? 62  GLU A N   1 
ATOM   224  C CA  . GLU A 1 34  ? 135.443 139.891 137.324 1.00 16.81 ? 62  GLU A CA  1 
ATOM   225  C C   . GLU A 1 34  ? 135.320 138.539 136.635 1.00 16.81 ? 62  GLU A C   1 
ATOM   226  O O   . GLU A 1 34  ? 134.262 138.205 136.091 1.00 16.81 ? 62  GLU A O   1 
ATOM   227  C CB  . GLU A 1 34  ? 134.172 140.710 137.100 1.00 16.81 ? 62  GLU A CB  1 
ATOM   228  C CG  . GLU A 1 34  ? 133.863 141.673 138.233 1.00 16.81 ? 62  GLU A CG  1 
ATOM   229  C CD  . GLU A 1 34  ? 132.382 141.958 138.369 1.00 16.81 ? 62  GLU A CD  1 
ATOM   230  O OE1 . GLU A 1 34  ? 131.585 141.320 137.650 1.00 16.81 ? 62  GLU A OE1 1 
ATOM   231  O OE2 . GLU A 1 34  ? 132.013 142.817 139.197 1.00 16.81 ? 62  GLU A OE2 1 
ATOM   232  N N   . ARG A 1 35  ? 136.395 137.755 136.655 1.00 19.26 ? 63  ARG A N   1 
ATOM   233  C CA  . ARG A 1 35  ? 136.276 136.321 136.442 1.00 19.26 ? 63  ARG A CA  1 
ATOM   234  C C   . ARG A 1 35  ? 135.714 135.618 137.668 1.00 19.26 ? 63  ARG A C   1 
ATOM   235  O O   . ARG A 1 35  ? 135.163 134.518 137.544 1.00 19.26 ? 63  ARG A O   1 
ATOM   236  C CB  . ARG A 1 35  ? 137.641 135.731 136.082 1.00 19.26 ? 63  ARG A CB  1 
ATOM   237  C CG  . ARG A 1 35  ? 137.616 134.260 135.728 1.00 19.26 ? 63  ARG A CG  1 
ATOM   238  C CD  . ARG A 1 35  ? 139.005 133.768 135.394 1.00 19.26 ? 63  ARG A CD  1 
ATOM   239  N NE  . ARG A 1 35  ? 139.873 133.791 136.564 1.00 19.26 ? 63  ARG A NE  1 
ATOM   240  C CZ  . ARG A 1 35  ? 141.181 133.573 136.523 1.00 19.26 ? 63  ARG A CZ  1 
ATOM   241  N NH1 . ARG A 1 35  ? 141.771 133.310 135.366 1.00 19.26 ? 63  ARG A NH1 1 
ATOM   242  N NH2 . ARG A 1 35  ? 141.897 133.615 137.637 1.00 19.26 ? 63  ARG A NH2 1 
ATOM   243  N N   . LEU A 1 36  ? 135.817 136.247 138.836 1.00 15.64 ? 64  LEU A N   1 
ATOM   244  C CA  . LEU A 1 36  ? 135.318 135.726 140.103 1.00 15.64 ? 64  LEU A CA  1 
ATOM   245  C C   . LEU A 1 36  ? 133.983 136.417 140.367 1.00 15.64 ? 64  LEU A C   1 
ATOM   246  O O   . LEU A 1 36  ? 133.929 137.507 140.937 1.00 15.64 ? 64  LEU A O   1 
ATOM   247  C CB  . LEU A 1 36  ? 136.325 135.974 141.217 1.00 15.64 ? 64  LEU A CB  1 
ATOM   248  C CG  . LEU A 1 36  ? 137.744 135.507 140.886 1.00 15.64 ? 64  LEU A CG  1 
ATOM   249  C CD1 . LEU A 1 36  ? 138.771 136.220 141.743 1.00 15.64 ? 64  LEU A CD1 1 
ATOM   250  C CD2 . LEU A 1 36  ? 137.861 134.003 141.052 1.00 15.64 ? 64  LEU A CD2 1 
ATOM   251  N N   . GLN A 1 37  ? 132.903 135.769 139.940 1.00 16.64 ? 65  GLN A N   1 
ATOM   252  C CA  . GLN A 1 37  ? 131.558 136.332 139.945 1.00 16.64 ? 65  GLN A CA  1 
ATOM   253  C C   . GLN A 1 37  ? 130.595 135.372 140.639 1.00 16.64 ? 65  GLN A C   1 
ATOM   254  O O   . GLN A 1 37  ? 129.522 135.031 140.135 1.00 16.64 ? 65  GLN A O   1 
ATOM   255  C CB  . GLN A 1 37  ? 131.130 136.661 138.513 1.00 16.64 ? 65  GLN A CB  1 
ATOM   256  C CG  . GLN A 1 37  ? 129.786 137.358 138.383 1.00 16.64 ? 65  GLN A CG  1 
ATOM   257  C CD  . GLN A 1 37  ? 129.696 138.592 139.245 1.00 16.64 ? 65  GLN A CD  1 
ATOM   258  O OE1 . GLN A 1 37  ? 129.077 138.572 140.308 1.00 16.64 ? 65  GLN A OE1 1 
ATOM   259  N NE2 . GLN A 1 37  ? 130.308 139.679 138.792 1.00 16.64 ? 65  GLN A NE2 1 
ATOM   260  N N   . THR A 1 38  ? 130.991 134.898 141.812 1.00 10.84 ? 66  THR A N   1 
ATOM   261  C CA  . THR A 1 38  ? 130.177 133.984 142.594 1.00 10.84 ? 66  THR A CA  1 
ATOM   262  C C   . THR A 1 38  ? 129.587 134.724 143.788 1.00 10.84 ? 66  THR A C   1 
ATOM   263  O O   . THR A 1 38  ? 130.206 135.636 144.340 1.00 10.84 ? 66  THR A O   1 
ATOM   264  C CB  . THR A 1 38  ? 131.014 132.790 143.060 1.00 10.84 ? 66  THR A CB  1 
ATOM   265  O OG1 . THR A 1 38  ? 131.531 132.101 141.916 1.00 10.84 ? 66  THR A OG1 1 
ATOM   266  C CG2 . THR A 1 38  ? 130.173 131.813 143.866 1.00 10.84 ? 66  THR A CG2 1 
ATOM   267  N N   . VAL A 1 39  ? 128.368 134.336 144.170 1.00 8.84  ? 67  VAL A N   1 
ATOM   268  C CA  . VAL A 1 39  ? 127.722 134.946 145.329 1.00 8.84  ? 67  VAL A CA  1 
ATOM   269  C C   . VAL A 1 39  ? 128.579 134.758 146.575 1.00 8.84  ? 67  VAL A C   1 
ATOM   270  O O   . VAL A 1 39  ? 128.688 135.660 147.420 1.00 8.84  ? 67  VAL A O   1 
ATOM   271  C CB  . VAL A 1 39  ? 126.310 134.364 145.511 1.00 8.84  ? 67  VAL A CB  1 
ATOM   272  C CG1 . VAL A 1 39  ? 125.631 134.991 146.701 1.00 8.84  ? 67  VAL A CG1 1 
ATOM   273  C CG2 . VAL A 1 39  ? 125.490 134.585 144.259 1.00 8.84  ? 67  VAL A CG2 1 
ATOM   274  N N   . THR A 1 40  ? 129.202 133.585 146.709 1.00 7.43  ? 68  THR A N   1 
ATOM   275  C CA  . THR A 1 40  ? 130.175 133.383 147.775 1.00 7.43  ? 68  THR A CA  1 
ATOM   276  C C   . THR A 1 40  ? 131.297 134.411 147.706 1.00 7.43  ? 68  THR A C   1 
ATOM   277  O O   . THR A 1 40  ? 131.792 134.854 148.746 1.00 7.43  ? 68  THR A O   1 
ATOM   278  C CB  . THR A 1 40  ? 130.736 131.963 147.704 1.00 7.43  ? 68  THR A CB  1 
ATOM   279  O OG1 . THR A 1 40  ? 129.673 131.025 147.900 1.00 7.43  ? 68  THR A OG1 1 
ATOM   280  C CG2 . THR A 1 40  ? 131.794 131.746 148.763 1.00 7.43  ? 68  THR A CG2 1 
ATOM   281  N N   . ASN A 1 41  ? 131.693 134.830 146.502 1.00 9.55  ? 69  ASN A N   1 
ATOM   282  C CA  . ASN A 1 41  ? 132.710 135.872 146.405 1.00 9.55  ? 69  ASN A CA  1 
ATOM   283  C C   . ASN A 1 41  ? 132.179 137.226 146.857 1.00 9.55  ? 69  ASN A C   1 
ATOM   284  O O   . ASN A 1 41  ? 132.941 138.033 147.397 1.00 9.55  ? 69  ASN A O   1 
ATOM   285  C CB  . ASN A 1 41  ? 133.260 135.957 144.984 1.00 9.55  ? 69  ASN A CB  1 
ATOM   286  C CG  . ASN A 1 41  ? 134.294 134.888 144.699 1.00 9.55  ? 69  ASN A CG  1 
ATOM   287  O OD1 . ASN A 1 41  ? 134.091 134.019 143.852 1.00 9.55  ? 69  ASN A OD1 1 
ATOM   288  N ND2 . ASN A 1 41  ? 135.414 134.947 145.409 1.00 9.55  ? 69  ASN A ND2 1 
ATOM   289  N N   . TYR A 1 42  ? 130.886 137.499 146.663 1.00 10.53 ? 70  TYR A N   1 
ATOM   290  C CA  . TYR A 1 42  ? 130.316 138.721 147.226 1.00 10.53 ? 70  TYR A CA  1 
ATOM   291  C C   . TYR A 1 42  ? 130.295 138.677 148.749 1.00 10.53 ? 70  TYR A C   1 
ATOM   292  O O   . TYR A 1 42  ? 130.581 139.683 149.409 1.00 10.53 ? 70  TYR A O   1 
ATOM   293  C CB  . TYR A 1 42  ? 128.917 138.970 146.670 1.00 10.53 ? 70  TYR A CB  1 
ATOM   294  C CG  . TYR A 1 42  ? 128.924 139.459 145.243 1.00 10.53 ? 70  TYR A CG  1 
ATOM   295  C CD1 . TYR A 1 42  ? 130.088 139.947 144.666 1.00 10.53 ? 70  TYR A CD1 1 
ATOM   296  C CD2 . TYR A 1 42  ? 127.767 139.451 144.478 1.00 10.53 ? 70  TYR A CD2 1 
ATOM   297  C CE1 . TYR A 1 42  ? 130.103 140.403 143.367 1.00 10.53 ? 70  TYR A CE1 1 
ATOM   298  C CE2 . TYR A 1 42  ? 127.773 139.905 143.176 1.00 10.53 ? 70  TYR A CE2 1 
ATOM   299  C CZ  . TYR A 1 42  ? 128.943 140.381 142.627 1.00 10.53 ? 70  TYR A CZ  1 
ATOM   300  O OH  . TYR A 1 42  ? 128.953 140.833 141.329 1.00 10.53 ? 70  TYR A OH  1 
ATOM   301  N N   . PHE A 1 43  ? 129.970 137.522 149.330 1.00 11.05 ? 71  PHE A N   1 
ATOM   302  C CA  . PHE A 1 43  ? 130.062 137.405 150.783 1.00 11.05 ? 71  PHE A CA  1 
ATOM   303  C C   . PHE A 1 43  ? 131.499 137.583 151.257 1.00 11.05 ? 71  PHE A C   1 
ATOM   304  O O   . PHE A 1 43  ? 131.752 138.227 152.283 1.00 11.05 ? 71  PHE A O   1 
ATOM   305  C CB  . PHE A 1 43  ? 129.515 136.060 151.241 1.00 11.05 ? 71  PHE A CB  1 
ATOM   306  C CG  . PHE A 1 43  ? 128.036 135.918 151.068 1.00 11.05 ? 71  PHE A CG  1 
ATOM   307  C CD1 . PHE A 1 43  ? 127.167 136.777 151.711 1.00 11.05 ? 71  PHE A CD1 1 
ATOM   308  C CD2 . PHE A 1 43  ? 127.515 134.914 150.274 1.00 11.05 ? 71  PHE A CD2 1 
ATOM   309  C CE1 . PHE A 1 43  ? 125.808 136.640 151.558 1.00 11.05 ? 71  PHE A CE1 1 
ATOM   310  C CE2 . PHE A 1 43  ? 126.156 134.773 150.120 1.00 11.05 ? 71  PHE A CE2 1 
ATOM   311  C CZ  . PHE A 1 43  ? 125.303 135.637 150.761 1.00 11.05 ? 71  PHE A CZ  1 
ATOM   312  N N   . ILE A 1 44  ? 132.453 137.025 150.513 1.00 6.82  ? 72  ILE A N   1 
ATOM   313  C CA  . ILE A 1 44  ? 133.861 137.157 150.869 1.00 6.82  ? 72  ILE A CA  1 
ATOM   314  C C   . ILE A 1 44  ? 134.302 138.614 150.815 1.00 6.82  ? 72  ILE A C   1 
ATOM   315  O O   . ILE A 1 44  ? 135.027 139.086 151.697 1.00 6.82  ? 72  ILE A O   1 
ATOM   316  C CB  . ILE A 1 44  ? 134.723 136.262 149.960 1.00 6.82  ? 72  ILE A CB  1 
ATOM   317  C CG1 . ILE A 1 44  ? 134.672 134.816 150.453 1.00 6.82  ? 72  ILE A CG1 1 
ATOM   318  C CG2 . ILE A 1 44  ? 136.146 136.774 149.889 1.00 6.82  ? 72  ILE A CG2 1 
ATOM   319  C CD1 . ILE A 1 44  ? 135.269 133.821 149.493 1.00 6.82  ? 72  ILE A CD1 1 
ATOM   320  N N   . THR A 1 45  ? 133.885 139.353 149.784 1.00 7.99  ? 73  THR A N   1 
ATOM   321  C CA  . THR A 1 45  ? 134.292 140.753 149.714 1.00 7.99  ? 73  THR A CA  1 
ATOM   322  C C   . THR A 1 45  ? 133.578 141.596 150.765 1.00 7.99  ? 73  THR A C   1 
ATOM   323  O O   . THR A 1 45  ? 134.142 142.588 151.241 1.00 7.99  ? 73  THR A O   1 
ATOM   324  C CB  . THR A 1 45  ? 134.069 141.325 148.311 1.00 7.99  ? 73  THR A CB  1 
ATOM   325  O OG1 . THR A 1 45  ? 134.748 142.582 148.201 1.00 7.99  ? 73  THR A OG1 1 
ATOM   326  C CG2 . THR A 1 45  ? 132.599 141.550 148.030 1.00 7.99  ? 73  THR A CG2 1 
ATOM   327  N N   . SER A 1 46  ? 132.358 141.217 151.160 1.00 7.28  ? 74  SER A N   1 
ATOM   328  C CA  . SER A 1 46  ? 131.729 141.876 152.302 1.00 7.28  ? 74  SER A CA  1 
ATOM   329  C C   . SER A 1 46  ? 132.549 141.665 153.567 1.00 7.28  ? 74  SER A C   1 
ATOM   330  O O   . SER A 1 46  ? 132.797 142.609 154.327 1.00 7.28  ? 74  SER A O   1 
ATOM   331  C CB  . SER A 1 46  ? 130.307 141.357 152.499 1.00 7.28  ? 74  SER A CB  1 
ATOM   332  O OG  . SER A 1 46  ? 129.719 141.916 153.661 1.00 7.28  ? 74  SER A OG  1 
ATOM   333  N N   . LEU A 1 47  ? 132.996 140.433 153.795 1.00 6.87  ? 75  LEU A N   1 
ATOM   334  C CA  . LEU A 1 47  ? 133.841 140.156 154.951 1.00 6.87  ? 75  LEU A CA  1 
ATOM   335  C C   . LEU A 1 47  ? 135.147 140.936 154.874 1.00 6.87  ? 75  LEU A C   1 
ATOM   336  O O   . LEU A 1 47  ? 135.644 141.438 155.890 1.00 6.87  ? 75  LEU A O   1 
ATOM   337  C CB  . LEU A 1 47  ? 134.102 138.653 155.042 1.00 6.87  ? 75  LEU A CB  1 
ATOM   338  C CG  . LEU A 1 47  ? 134.830 138.082 156.247 1.00 6.87  ? 75  LEU A CG  1 
ATOM   339  C CD1 . LEU A 1 47  ? 134.222 136.751 156.597 1.00 6.87  ? 75  LEU A CD1 1 
ATOM   340  C CD2 . LEU A 1 47  ? 136.286 137.906 155.910 1.00 6.87  ? 75  LEU A CD2 1 
ATOM   341  N N   . ALA A 1 48  ? 135.717 141.047 153.674 1.00 9.14  ? 76  ALA A N   1 
ATOM   342  C CA  . ALA A 1 48  ? 136.987 141.746 153.512 1.00 9.14  ? 76  ALA A CA  1 
ATOM   343  C C   . ALA A 1 48  ? 136.845 143.240 153.781 1.00 9.14  ? 76  ALA A C   1 
ATOM   344  O O   . ALA A 1 48  ? 137.691 143.836 154.456 1.00 9.14  ? 76  ALA A O   1 
ATOM   345  C CB  . ALA A 1 48  ? 137.546 141.500 152.112 1.00 9.14  ? 76  ALA A CB  1 
ATOM   346  N N   . CYS A 1 49  ? 135.788 143.871 153.267 1.00 10.14 ? 77  CYS A N   1 
ATOM   347  C CA  . CYS A 1 49  ? 135.607 145.284 153.580 1.00 10.14 ? 77  CYS A CA  1 
ATOM   348  C C   . CYS A 1 49  ? 135.284 145.477 155.056 1.00 10.14 ? 77  CYS A C   1 
ATOM   349  O O   . CYS A 1 49  ? 135.707 146.473 155.654 1.00 10.14 ? 77  CYS A O   1 
ATOM   350  C CB  . CYS A 1 49  ? 134.530 145.911 152.691 1.00 10.14 ? 77  CYS A CB  1 
ATOM   351  S SG  . CYS A 1 49  ? 132.834 145.388 152.994 1.00 10.14 ? 77  CYS A SG  1 
ATOM   352  N N   . ALA A 1 50  ? 134.579 144.522 155.672 1.00 8.42  ? 78  ALA A N   1 
ATOM   353  C CA  . ALA A 1 50  ? 134.321 144.604 157.106 1.00 8.42  ? 78  ALA A CA  1 
ATOM   354  C C   . ALA A 1 50  ? 135.617 144.587 157.905 1.00 8.42  ? 78  ALA A C   1 
ATOM   355  O O   . ALA A 1 50  ? 135.822 145.419 158.799 1.00 8.42  ? 78  ALA A O   1 
ATOM   356  C CB  . ALA A 1 50  ? 133.415 143.454 157.540 1.00 8.42  ? 78  ALA A CB  1 
ATOM   357  N N   . ASP A 1 51  ? 136.516 143.650 157.597 1.00 10.24 ? 79  ASP A N   1 
ATOM   358  C CA  . ASP A 1 51  ? 137.733 143.564 158.396 1.00 10.24 ? 79  ASP A CA  1 
ATOM   359  C C   . ASP A 1 51  ? 138.699 144.701 158.069 1.00 10.24 ? 79  ASP A C   1 
ATOM   360  O O   . ASP A 1 51  ? 139.485 145.107 158.930 1.00 10.24 ? 79  ASP A O   1 
ATOM   361  C CB  . ASP A 1 51  ? 138.382 142.177 158.252 1.00 10.24 ? 79  ASP A CB  1 
ATOM   362  C CG  . ASP A 1 51  ? 139.276 142.032 157.026 1.00 10.24 ? 79  ASP A CG  1 
ATOM   363  O OD1 . ASP A 1 51  ? 139.346 142.930 156.173 1.00 10.24 ? 79  ASP A OD1 1 
ATOM   364  O OD2 . ASP A 1 51  ? 139.931 140.976 156.916 1.00 10.24 ? 79  ASP A OD2 1 
ATOM   365  N N   . LEU A 1 52  ? 138.646 145.241 156.847 1.00 10.96 ? 80  LEU A N   1 
ATOM   366  C CA  . LEU A 1 52  ? 139.407 146.454 156.555 1.00 10.96 ? 80  LEU A CA  1 
ATOM   367  C C   . LEU A 1 52  ? 138.899 147.632 157.374 1.00 10.96 ? 80  LEU A C   1 
ATOM   368  O O   . LEU A 1 52  ? 139.693 148.436 157.881 1.00 10.96 ? 80  LEU A O   1 
ATOM   369  C CB  . LEU A 1 52  ? 139.342 146.782 155.064 1.00 10.96 ? 80  LEU A CB  1 
ATOM   370  C CG  . LEU A 1 52  ? 140.120 148.033 154.650 1.00 10.96 ? 80  LEU A CG  1 
ATOM   371  C CD1 . LEU A 1 52  ? 141.604 147.732 154.515 1.00 10.96 ? 80  LEU A CD1 1 
ATOM   372  C CD2 . LEU A 1 52  ? 139.562 148.616 153.363 1.00 10.96 ? 80  LEU A CD2 1 
ATOM   373  N N   . VAL A 1 53  ? 137.576 147.766 157.494 1.00 10.15 ? 81  VAL A N   1 
ATOM   374  C CA  . VAL A 1 53  ? 137.012 148.801 158.355 1.00 10.15 ? 81  VAL A CA  1 
ATOM   375  C C   . VAL A 1 53  ? 137.500 148.608 159.782 1.00 10.15 ? 81  VAL A C   1 
ATOM   376  O O   . VAL A 1 53  ? 137.901 149.564 160.456 1.00 10.15 ? 81  VAL A O   1 
ATOM   377  C CB  . VAL A 1 53  ? 135.475 148.790 158.276 1.00 10.15 ? 81  VAL A CB  1 
ATOM   378  C CG1 . VAL A 1 53  ? 134.870 149.506 159.475 1.00 10.15 ? 81  VAL A CG1 1 
ATOM   379  C CG2 . VAL A 1 53  ? 135.010 149.434 156.980 1.00 10.15 ? 81  VAL A CG2 1 
ATOM   380  N N   . MET A 1 54  ? 137.487 147.361 160.254 1.00 12.46 ? 82  MET A N   1 
ATOM   381  C CA  . MET A 1 54  ? 137.963 147.077 161.604 1.00 12.46 ? 82  MET A CA  1 
ATOM   382  C C   . MET A 1 54  ? 139.412 147.504 161.773 1.00 12.46 ? 82  MET A C   1 
ATOM   383  O O   . MET A 1 54  ? 139.762 148.180 162.745 1.00 12.46 ? 82  MET A O   1 
ATOM   384  C CB  . MET A 1 54  ? 137.807 145.590 161.917 1.00 12.46 ? 82  MET A CB  1 
ATOM   385  C CG  . MET A 1 54  ? 138.484 145.148 163.201 1.00 12.46 ? 82  MET A CG  1 
ATOM   386  S SD  . MET A 1 54  ? 138.531 143.356 163.354 1.00 12.46 ? 82  MET A SD  1 
ATOM   387  C CE  . MET A 1 54  ? 138.534 143.174 165.132 1.00 12.46 ? 82  MET A CE  1 
ATOM   388  N N   . GLY A 1 55  ? 140.268 147.121 160.831 1.00 13.85 ? 83  GLY A N   1 
ATOM   389  C CA  . GLY A 1 55  ? 141.657 147.525 160.861 1.00 13.85 ? 83  GLY A CA  1 
ATOM   390  C C   . GLY A 1 55  ? 141.796 149.027 160.977 1.00 13.85 ? 83  GLY A C   1 
ATOM   391  O O   . GLY A 1 55  ? 142.236 149.533 162.019 1.00 13.85 ? 83  GLY A O   1 
ATOM   392  N N   . LEU A 1 56  ? 141.337 149.734 159.937 1.00 14.60 ? 84  LEU A N   1 
ATOM   393  C CA  . LEU A 1 56  ? 141.485 151.186 159.870 1.00 14.60 ? 84  LEU A CA  1 
ATOM   394  C C   . LEU A 1 56  ? 140.933 151.878 161.106 1.00 14.60 ? 84  LEU A C   1 
ATOM   395  O O   . LEU A 1 56  ? 141.490 152.888 161.549 1.00 14.60 ? 84  LEU A O   1 
ATOM   396  C CB  . LEU A 1 56  ? 140.780 151.735 158.627 1.00 14.60 ? 84  LEU A CB  1 
ATOM   397  C CG  . LEU A 1 56  ? 141.596 152.048 157.372 1.00 14.60 ? 84  LEU A CG  1 
ATOM   398  C CD1 . LEU A 1 56  ? 142.423 150.853 156.957 1.00 14.60 ? 84  LEU A CD1 1 
ATOM   399  C CD2 . LEU A 1 56  ? 140.682 152.489 156.241 1.00 14.60 ? 84  LEU A CD2 1 
ATOM   400  N N   . ALA A 1 57  ? 139.848 151.358 161.681 1.00 15.31 ? 85  ALA A N   1 
ATOM   401  C CA  . ALA A 1 57  ? 139.227 152.047 162.803 1.00 15.31 ? 85  ALA A CA  1 
ATOM   402  C C   . ALA A 1 57  ? 139.965 151.772 164.106 1.00 15.31 ? 85  ALA A C   1 
ATOM   403  O O   . ALA A 1 57  ? 140.411 152.706 164.782 1.00 15.31 ? 85  ALA A O   1 
ATOM   404  C CB  . ALA A 1 57  ? 137.760 151.644 162.918 1.00 15.31 ? 85  ALA A CB  1 
ATOM   405  N N   . VAL A 1 58  ? 140.117 150.504 164.479 1.00 15.61 ? 86  VAL A N   1 
ATOM   406  C CA  . VAL A 1 58  ? 140.511 150.163 165.838 1.00 15.61 ? 86  VAL A CA  1 
ATOM   407  C C   . VAL A 1 58  ? 142.011 149.921 165.963 1.00 15.61 ? 86  VAL A C   1 
ATOM   408  O O   . VAL A 1 58  ? 142.601 150.292 166.978 1.00 15.61 ? 86  VAL A O   1 
ATOM   409  C CB  . VAL A 1 58  ? 139.704 148.952 166.362 1.00 15.61 ? 86  VAL A CB  1 
ATOM   410  C CG1 . VAL A 1 58  ? 140.079 147.676 165.645 1.00 15.61 ? 86  VAL A CG1 1 
ATOM   411  C CG2 . VAL A 1 58  ? 139.900 148.793 167.857 1.00 15.61 ? 86  VAL A CG2 1 
ATOM   412  N N   . VAL A 1 59  ? 142.665 149.302 164.968 1.00 15.02 ? 87  VAL A N   1 
ATOM   413  C CA  . VAL A 1 59  ? 144.032 148.821 165.185 1.00 15.02 ? 87  VAL A CA  1 
ATOM   414  C C   . VAL A 1 59  ? 145.000 149.955 165.515 1.00 15.02 ? 87  VAL A C   1 
ATOM   415  O O   . VAL A 1 59  ? 145.690 149.863 166.546 1.00 15.02 ? 87  VAL A O   1 
ATOM   416  C CB  . VAL A 1 59  ? 144.493 147.970 163.989 1.00 15.02 ? 87  VAL A CB  1 
ATOM   417  C CG1 . VAL A 1 59  ? 145.921 147.507 164.198 1.00 15.02 ? 87  VAL A CG1 1 
ATOM   418  C CG2 . VAL A 1 59  ? 143.577 146.780 163.815 1.00 15.02 ? 87  VAL A CG2 1 
ATOM   419  N N   . PRO A 1 60  ? 145.102 151.032 164.724 1.00 16.81 ? 88  PRO A N   1 
ATOM   420  C CA  . PRO A 1 60  ? 145.994 152.129 165.137 1.00 16.81 ? 88  PRO A CA  1 
ATOM   421  C C   . PRO A 1 60  ? 145.578 152.764 166.450 1.00 16.81 ? 88  PRO A C   1 
ATOM   422  O O   . PRO A 1 60  ? 146.437 153.134 167.259 1.00 16.81 ? 88  PRO A O   1 
ATOM   423  C CB  . PRO A 1 60  ? 145.897 153.121 163.968 1.00 16.81 ? 88  PRO A CB  1 
ATOM   424  C CG  . PRO A 1 60  ? 145.351 152.333 162.828 1.00 16.81 ? 88  PRO A CG  1 
ATOM   425  C CD  . PRO A 1 60  ? 144.425 151.348 163.454 1.00 16.81 ? 88  PRO A CD  1 
ATOM   426  N N   . PHE A 1 61  ? 144.272 152.885 166.688 1.00 19.54 ? 89  PHE A N   1 
ATOM   427  C CA  . PHE A 1 61  ? 143.795 153.503 167.921 1.00 19.54 ? 89  PHE A CA  1 
ATOM   428  C C   . PHE A 1 61  ? 144.134 152.644 169.131 1.00 19.54 ? 89  PHE A C   1 
ATOM   429  O O   . PHE A 1 61  ? 144.583 153.160 170.160 1.00 19.54 ? 89  PHE A O   1 
ATOM   430  C CB  . PHE A 1 61  ? 142.288 153.747 167.836 1.00 19.54 ? 89  PHE A CB  1 
ATOM   431  C CG  . PHE A 1 61  ? 141.892 154.806 166.840 1.00 19.54 ? 89  PHE A CG  1 
ATOM   432  C CD1 . PHE A 1 61  ? 140.582 155.245 166.772 1.00 19.54 ? 89  PHE A CD1 1 
ATOM   433  C CD2 . PHE A 1 61  ? 142.825 155.376 165.990 1.00 19.54 ? 89  PHE A CD2 1 
ATOM   434  C CE1 . PHE A 1 61  ? 140.209 156.213 165.864 1.00 19.54 ? 89  PHE A CE1 1 
ATOM   435  C CE2 . PHE A 1 61  ? 142.457 156.346 165.083 1.00 19.54 ? 89  PHE A CE2 1 
ATOM   436  C CZ  . PHE A 1 61  ? 141.146 156.767 165.022 1.00 19.54 ? 89  PHE A CZ  1 
ATOM   437  N N   . GLY A 1 62  ? 143.924 151.331 169.025 1.00 16.50 ? 90  GLY A N   1 
ATOM   438  C CA  . GLY A 1 62  ? 144.310 150.444 170.107 1.00 16.50 ? 90  GLY A CA  1 
ATOM   439  C C   . GLY A 1 62  ? 145.806 150.452 170.352 1.00 16.50 ? 90  GLY A C   1 
ATOM   440  O O   . GLY A 1 62  ? 146.258 150.436 171.500 1.00 16.50 ? 90  GLY A O   1 
ATOM   441  N N   . ALA A 1 63  ? 146.595 150.482 169.275 1.00 17.99 ? 91  ALA A N   1 
ATOM   442  C CA  . ALA A 1 63  ? 148.044 150.549 169.433 1.00 17.99 ? 91  ALA A CA  1 
ATOM   443  C C   . ALA A 1 63  ? 148.464 151.831 170.142 1.00 17.99 ? 91  ALA A C   1 
ATOM   444  O O   . ALA A 1 63  ? 149.331 151.806 171.024 1.00 17.99 ? 91  ALA A O   1 
ATOM   445  C CB  . ALA A 1 63  ? 148.727 150.438 168.071 1.00 17.99 ? 91  ALA A CB  1 
ATOM   446  N N   . ALA A 1 64  ? 147.860 152.962 169.770 1.00 17.26 ? 92  ALA A N   1 
ATOM   447  C CA  . ALA A 1 64  ? 148.179 154.223 170.432 1.00 17.26 ? 92  ALA A CA  1 
ATOM   448  C C   . ALA A 1 64  ? 147.776 154.194 171.899 1.00 17.26 ? 92  ALA A C   1 
ATOM   449  O O   . ALA A 1 64  ? 148.525 154.658 172.766 1.00 17.26 ? 92  ALA A O   1 
ATOM   450  C CB  . ALA A 1 64  ? 147.495 155.383 169.710 1.00 17.26 ? 92  ALA A CB  1 
ATOM   451  N N   . HIS A 1 65  ? 146.593 153.649 172.197 1.00 18.88 ? 93  HIS A N   1 
ATOM   452  C CA  . HIS A 1 65  ? 146.155 153.535 173.584 1.00 18.88 ? 93  HIS A CA  1 
ATOM   453  C C   . HIS A 1 65  ? 147.130 152.699 174.399 1.00 18.88 ? 93  HIS A C   1 
ATOM   454  O O   . HIS A 1 65  ? 147.459 153.049 175.538 1.00 18.88 ? 93  HIS A O   1 
ATOM   455  C CB  . HIS A 1 65  ? 144.751 152.928 173.640 1.00 18.88 ? 93  HIS A CB  1 
ATOM   456  C CG  . HIS A 1 65  ? 144.283 152.598 175.025 1.00 18.88 ? 93  HIS A CG  1 
ATOM   457  N ND1 . HIS A 1 65  ? 144.773 151.529 175.745 1.00 18.88 ? 93  HIS A ND1 1 
ATOM   458  C CD2 . HIS A 1 65  ? 143.357 153.188 175.817 1.00 18.88 ? 93  HIS A CD2 1 
ATOM   459  C CE1 . HIS A 1 65  ? 144.177 151.482 176.923 1.00 18.88 ? 93  HIS A CE1 1 
ATOM   460  N NE2 . HIS A 1 65  ? 143.313 152.478 176.992 1.00 18.88 ? 93  HIS A NE2 1 
ATOM   461  N N   . ILE A 1 66  ? 147.596 151.585 173.836 1.00 18.43 ? 94  ILE A N   1 
ATOM   462  C CA  . ILE A 1 66  ? 148.522 150.724 174.563 1.00 18.43 ? 94  ILE A CA  1 
ATOM   463  C C   . ILE A 1 66  ? 149.863 151.421 174.764 1.00 18.43 ? 94  ILE A C   1 
ATOM   464  O O   . ILE A 1 66  ? 150.435 151.388 175.860 1.00 18.43 ? 94  ILE A O   1 
ATOM   465  C CB  . ILE A 1 66  ? 148.682 149.379 173.832 1.00 18.43 ? 94  ILE A CB  1 
ATOM   466  C CG1 . ILE A 1 66  ? 147.359 148.610 173.846 1.00 18.43 ? 94  ILE A CG1 1 
ATOM   467  C CG2 . ILE A 1 66  ? 149.793 148.555 174.461 1.00 18.43 ? 94  ILE A CG2 1 
ATOM   468  C CD1 . ILE A 1 66  ? 146.808 148.364 175.233 1.00 18.43 ? 94  ILE A CD1 1 
ATOM   469  N N   . LEU A 1 67  ? 150.386 152.063 173.716 1.00 20.73 ? 95  LEU A N   1 
ATOM   470  C CA  . LEU A 1 67  ? 151.729 152.633 173.791 1.00 20.73 ? 95  LEU A CA  1 
ATOM   471  C C   . LEU A 1 67  ? 151.775 153.858 174.698 1.00 20.73 ? 95  LEU A C   1 
ATOM   472  O O   . LEU A 1 67  ? 152.651 153.968 175.564 1.00 20.73 ? 95  LEU A O   1 
ATOM   473  C CB  . LEU A 1 67  ? 152.226 152.983 172.389 1.00 20.73 ? 95  LEU A CB  1 
ATOM   474  C CG  . LEU A 1 67  ? 152.715 151.802 171.552 1.00 20.73 ? 95  LEU A CG  1 
ATOM   475  C CD1 . LEU A 1 67  ? 153.094 152.256 170.152 1.00 20.73 ? 95  LEU A CD1 1 
ATOM   476  C CD2 . LEU A 1 67  ? 153.886 151.117 172.236 1.00 20.73 ? 95  LEU A CD2 1 
ATOM   477  N N   . MET A 1 68  ? 150.842 154.792 174.517 1.00 20.07 ? 96  MET A N   1 
ATOM   478  C CA  . MET A 1 68  ? 150.885 156.040 175.266 1.00 20.07 ? 96  MET A CA  1 
ATOM   479  C C   . MET A 1 68  ? 150.443 155.886 176.715 1.00 20.07 ? 96  MET A C   1 
ATOM   480  O O   . MET A 1 68  ? 150.601 156.834 177.491 1.00 20.07 ? 96  MET A O   1 
ATOM   481  C CB  . MET A 1 68  ? 150.014 157.095 174.579 1.00 20.07 ? 96  MET A CB  1 
ATOM   482  C CG  . MET A 1 68  ? 150.405 157.386 173.140 1.00 20.07 ? 96  MET A CG  1 
ATOM   483  S SD  . MET A 1 68  ? 152.182 157.279 172.864 1.00 20.07 ? 96  MET A SD  1 
ATOM   484  C CE  . MET A 1 68  ? 152.299 157.881 171.182 1.00 20.07 ? 96  MET A CE  1 
ATOM   485  N N   . LYS A 1 69  ? 149.893 154.731 177.091 1.00 21.01 ? 97  LYS A N   1 
ATOM   486  C CA  . LYS A 1 69  ? 149.358 154.477 178.429 1.00 21.01 ? 97  LYS A CA  1 
ATOM   487  C C   . LYS A 1 69  ? 148.238 155.444 178.797 1.00 21.01 ? 97  LYS A C   1 
ATOM   488  O O   . LYS A 1 69  ? 147.903 155.591 179.976 1.00 21.01 ? 97  LYS A O   1 
ATOM   489  C CB  . LYS A 1 69  ? 150.461 154.515 179.494 1.00 21.01 ? 97  LYS A CB  1 
ATOM   490  C CG  . LYS A 1 69  ? 151.531 153.452 179.311 1.00 21.01 ? 97  LYS A CG  1 
ATOM   491  C CD  . LYS A 1 69  ? 150.924 152.057 179.276 1.00 21.01 ? 97  LYS A CD  1 
ATOM   492  C CE  . LYS A 1 69  ? 150.319 151.678 180.618 1.00 21.01 ? 97  LYS A CE  1 
ATOM   493  N NZ  . LYS A 1 69  ? 151.352 151.569 181.685 1.00 21.01 ? 97  LYS A NZ  1 
ATOM   494  N N   . MET A 1 70  ? 147.652 156.102 177.800 1.00 23.00 ? 98  MET A N   1 
ATOM   495  C CA  . MET A 1 70  ? 146.546 157.025 178.006 1.00 23.00 ? 98  MET A CA  1 
ATOM   496  C C   . MET A 1 70  ? 145.898 157.290 176.655 1.00 23.00 ? 98  MET A C   1 
ATOM   497  O O   . MET A 1 70  ? 146.591 157.390 175.640 1.00 23.00 ? 98  MET A O   1 
ATOM   498  C CB  . MET A 1 70  ? 147.018 158.333 178.656 1.00 23.00 ? 98  MET A CB  1 
ATOM   499  C CG  . MET A 1 70  ? 147.954 159.165 177.795 1.00 23.00 ? 98  MET A CG  1 
ATOM   500  S SD  . MET A 1 70  ? 148.519 160.662 178.624 1.00 23.00 ? 98  MET A SD  1 
ATOM   501  C CE  . MET A 1 70  ? 149.582 161.362 177.364 1.00 23.00 ? 98  MET A CE  1 
ATOM   502  N N   . TRP A 1 71  ? 144.573 157.387 176.647 1.00 23.97 ? 99  TRP A N   1 
ATOM   503  C CA  . TRP A 1 71  ? 143.808 157.536 175.413 1.00 23.97 ? 99  TRP A CA  1 
ATOM   504  C C   . TRP A 1 71  ? 143.151 158.910 175.472 1.00 23.97 ? 99  TRP A C   1 
ATOM   505  O O   . TRP A 1 71  ? 142.072 159.067 176.052 1.00 23.97 ? 99  TRP A O   1 
ATOM   506  C CB  . TRP A 1 71  ? 142.774 156.423 175.274 1.00 23.97 ? 99  TRP A CB  1 
ATOM   507  C CG  . TRP A 1 71  ? 142.166 156.323 173.912 1.00 23.97 ? 99  TRP A CG  1 
ATOM   508  C CD1 . TRP A 1 71  ? 142.790 155.912 172.773 1.00 23.97 ? 99  TRP A CD1 1 
ATOM   509  C CD2 . TRP A 1 71  ? 140.825 156.654 173.537 1.00 23.97 ? 99  TRP A CD2 1 
ATOM   510  N NE1 . TRP A 1 71  ? 141.920 155.952 171.714 1.00 23.97 ? 99  TRP A NE1 1 
ATOM   511  C CE2 . TRP A 1 71  ? 140.707 156.408 172.156 1.00 23.97 ? 99  TRP A CE2 1 
ATOM   512  C CE3 . TRP A 1 71  ? 139.715 157.134 174.233 1.00 23.97 ? 99  TRP A CE3 1 
ATOM   513  C CZ2 . TRP A 1 71  ? 139.525 156.624 171.460 1.00 23.97 ? 99  TRP A CZ2 1 
ATOM   514  C CZ3 . TRP A 1 71  ? 138.543 157.347 173.539 1.00 23.97 ? 99  TRP A CZ3 1 
ATOM   515  C CH2 . TRP A 1 71  ? 138.456 157.093 172.167 1.00 23.97 ? 99  TRP A CH2 1 
ATOM   516  N N   . THR A 1 72  ? 143.805 159.905 174.872 1.00 23.20 ? 100 THR A N   1 
ATOM   517  C CA  . THR A 1 72  ? 143.401 161.299 175.005 1.00 23.20 ? 100 THR A CA  1 
ATOM   518  C C   . THR A 1 72  ? 142.613 161.802 173.802 1.00 23.20 ? 100 THR A C   1 
ATOM   519  O O   . THR A 1 72  ? 142.469 163.015 173.626 1.00 23.20 ? 100 THR A O   1 
ATOM   520  C CB  . THR A 1 72  ? 144.627 162.182 175.234 1.00 23.20 ? 100 THR A CB  1 
ATOM   521  O OG1 . THR A 1 72  ? 144.209 163.535 175.449 1.00 23.20 ? 100 THR A OG1 1 
ATOM   522  C CG2 . THR A 1 72  ? 145.551 162.127 174.027 1.00 23.20 ? 100 THR A CG2 1 
ATOM   523  N N   . PHE A 1 73  ? 142.100 160.897 172.968 1.00 22.91 ? 101 PHE A N   1 
ATOM   524  C CA  . PHE A 1 73  ? 141.366 161.328 171.783 1.00 22.91 ? 101 PHE A CA  1 
ATOM   525  C C   . PHE A 1 73  ? 140.084 162.063 172.154 1.00 22.91 ? 101 PHE A C   1 
ATOM   526  O O   . PHE A 1 73  ? 139.726 163.056 171.512 1.00 22.91 ? 101 PHE A O   1 
ATOM   527  C CB  . PHE A 1 73  ? 141.061 160.129 170.889 1.00 22.91 ? 101 PHE A CB  1 
ATOM   528  C CG  . PHE A 1 73  ? 142.172 159.782 169.943 1.00 22.91 ? 101 PHE A CG  1 
ATOM   529  C CD1 . PHE A 1 73  ? 143.436 159.480 170.420 1.00 22.91 ? 101 PHE A CD1 1 
ATOM   530  C CD2 . PHE A 1 73  ? 141.954 159.760 168.577 1.00 22.91 ? 101 PHE A CD2 1 
ATOM   531  C CE1 . PHE A 1 73  ? 144.461 159.160 169.553 1.00 22.91 ? 101 PHE A CE1 1 
ATOM   532  C CE2 . PHE A 1 73  ? 142.975 159.442 167.705 1.00 22.91 ? 101 PHE A CE2 1 
ATOM   533  C CZ  . PHE A 1 73  ? 144.230 159.141 168.194 1.00 22.91 ? 101 PHE A CZ  1 
ATOM   534  N N   . GLY A 1 74  ? 139.380 161.595 173.179 1.00 23.03 ? 102 GLY A N   1 
ATOM   535  C CA  . GLY A 1 74  ? 138.153 162.254 173.585 1.00 23.03 ? 102 GLY A CA  1 
ATOM   536  C C   . GLY A 1 74  ? 137.358 161.383 174.536 1.00 23.03 ? 102 GLY A C   1 
ATOM   537  O O   . GLY A 1 74  ? 137.899 160.471 175.162 1.00 23.03 ? 102 GLY A O   1 
ATOM   538  N N   . ASN A 1 75  ? 136.066 161.686 174.636 1.00 24.22 ? 103 ASN A N   1 
ATOM   539  C CA  . ASN A 1 75  ? 135.154 160.944 175.498 1.00 24.22 ? 103 ASN A CA  1 
ATOM   540  C C   . ASN A 1 75  ? 134.005 160.295 174.746 1.00 24.22 ? 103 ASN A C   1 
ATOM   541  O O   . ASN A 1 75  ? 133.675 159.142 175.023 1.00 24.22 ? 103 ASN A O   1 
ATOM   542  C CB  . ASN A 1 75  ? 134.590 161.864 176.588 1.00 24.22 ? 103 ASN A CB  1 
ATOM   543  C CG  . ASN A 1 75  ? 134.145 161.102 177.817 1.00 24.22 ? 103 ASN A CG  1 
ATOM   544  O OD1 . ASN A 1 75  ? 134.567 159.969 178.043 1.00 24.22 ? 103 ASN A OD1 1 
ATOM   545  N ND2 . ASN A 1 75  ? 133.287 161.720 178.621 1.00 24.22 ? 103 ASN A ND2 1 
ATOM   546  N N   . PHE A 1 76  ? 133.377 161.006 173.807 1.00 23.17 ? 104 PHE A N   1 
ATOM   547  C CA  . PHE A 1 76  ? 132.321 160.411 172.992 1.00 23.17 ? 104 PHE A CA  1 
ATOM   548  C C   . PHE A 1 76  ? 132.918 159.509 171.916 1.00 23.17 ? 104 PHE A C   1 
ATOM   549  O O   . PHE A 1 76  ? 132.315 158.498 171.516 1.00 23.17 ? 104 PHE A O   1 
ATOM   550  C CB  . PHE A 1 76  ? 131.472 161.525 172.380 1.00 23.17 ? 104 PHE A CB  1 
ATOM   551  C CG  . PHE A 1 76  ? 130.158 161.064 171.834 1.00 23.17 ? 104 PHE A CG  1 
ATOM   552  C CD1 . PHE A 1 76  ? 129.103 160.791 172.687 1.00 23.17 ? 104 PHE A CD1 1 
ATOM   553  C CD2 . PHE A 1 76  ? 129.961 160.938 170.472 1.00 23.17 ? 104 PHE A CD2 1 
ATOM   554  C CE1 . PHE A 1 76  ? 127.882 160.379 172.195 1.00 23.17 ? 104 PHE A CE1 1 
ATOM   555  C CE2 . PHE A 1 76  ? 128.740 160.528 169.973 1.00 23.17 ? 104 PHE A CE2 1 
ATOM   556  C CZ  . PHE A 1 76  ? 127.700 160.247 170.835 1.00 23.17 ? 104 PHE A CZ  1 
ATOM   557  N N   . TRP A 1 77  ? 134.122 159.855 171.460 1.00 25.36 ? 105 TRP A N   1 
ATOM   558  C CA  . TRP A 1 77  ? 134.874 158.964 170.595 1.00 25.36 ? 105 TRP A CA  1 
ATOM   559  C C   . TRP A 1 77  ? 135.143 157.624 171.261 1.00 25.36 ? 105 TRP A C   1 
ATOM   560  O O   . TRP A 1 77  ? 135.346 156.633 170.560 1.00 25.36 ? 105 TRP A O   1 
ATOM   561  C CB  . TRP A 1 77  ? 136.189 159.622 170.179 1.00 25.36 ? 105 TRP A CB  1 
ATOM   562  C CG  . TRP A 1 77  ? 136.872 158.931 169.041 1.00 25.36 ? 105 TRP A CG  1 
ATOM   563  C CD1 . TRP A 1 77  ? 138.139 158.430 169.034 1.00 25.36 ? 105 TRP A CD1 1 
ATOM   564  C CD2 . TRP A 1 77  ? 136.325 158.657 167.745 1.00 25.36 ? 105 TRP A CD2 1 
ATOM   565  N NE1 . TRP A 1 77  ? 138.417 157.862 167.816 1.00 25.36 ? 105 TRP A NE1 1 
ATOM   566  C CE2 . TRP A 1 77  ? 137.320 157.988 167.007 1.00 25.36 ? 105 TRP A CE2 1 
ATOM   567  C CE3 . TRP A 1 77  ? 135.094 158.913 167.137 1.00 25.36 ? 105 TRP A CE3 1 
ATOM   568  C CZ2 . TRP A 1 77  ? 137.120 157.572 165.693 1.00 25.36 ? 105 TRP A CZ2 1 
ATOM   569  C CZ3 . TRP A 1 77  ? 134.897 158.497 165.834 1.00 25.36 ? 105 TRP A CZ3 1 
ATOM   570  C CH2 . TRP A 1 77  ? 135.904 157.835 165.126 1.00 25.36 ? 105 TRP A CH2 1 
ATOM   571  N N   . CYS A 1 78  ? 135.131 157.563 172.594 1.00 20.82 ? 106 CYS A N   1 
ATOM   572  C CA  . CYS A 1 78  ? 135.254 156.278 173.276 1.00 20.82 ? 106 CYS A CA  1 
ATOM   573  C C   . CYS A 1 78  ? 134.084 155.364 172.931 1.00 20.82 ? 106 CYS A C   1 
ATOM   574  O O   . CYS A 1 78  ? 134.275 154.190 172.585 1.00 20.82 ? 106 CYS A O   1 
ATOM   575  C CB  . CYS A 1 78  ? 135.347 156.501 174.787 1.00 20.82 ? 106 CYS A CB  1 
ATOM   576  S SG  . CYS A 1 78  ? 135.613 155.019 175.783 1.00 20.82 ? 106 CYS A SG  1 
ATOM   577  N N   . GLU A 1 79  ? 132.859 155.893 173.012 1.00 21.29 ? 107 GLU A N   1 
ATOM   578  C CA  . GLU A 1 79  ? 131.695 155.106 172.623 1.00 21.29 ? 107 GLU A CA  1 
ATOM   579  C C   . GLU A 1 79  ? 131.737 154.752 171.144 1.00 21.29 ? 107 GLU A C   1 
ATOM   580  O O   . GLU A 1 79  ? 131.426 153.615 170.767 1.00 21.29 ? 107 GLU A O   1 
ATOM   581  C CB  . GLU A 1 79  ? 130.401 155.847 172.962 1.00 21.29 ? 107 GLU A CB  1 
ATOM   582  C CG  . GLU A 1 79  ? 130.034 155.821 174.439 1.00 21.29 ? 107 GLU A CG  1 
ATOM   583  C CD  . GLU A 1 79  ? 130.719 156.907 175.233 1.00 21.29 ? 107 GLU A CD  1 
ATOM   584  O OE1 . GLU A 1 79  ? 131.407 157.741 174.615 1.00 21.29 ? 107 GLU A OE1 1 
ATOM   585  O OE2 . GLU A 1 79  ? 130.570 156.926 176.472 1.00 21.29 ? 107 GLU A OE2 1 
ATOM   586  N N   . PHE A 1 80  ? 132.126 155.702 170.288 1.00 22.51 ? 108 PHE A N   1 
ATOM   587  C CA  . PHE A 1 80  ? 132.251 155.367 168.868 1.00 22.51 ? 108 PHE A CA  1 
ATOM   588  C C   . PHE A 1 80  ? 133.242 154.229 168.646 1.00 22.51 ? 108 PHE A C   1 
ATOM   589  O O   . PHE A 1 80  ? 132.970 153.299 167.879 1.00 22.51 ? 108 PHE A O   1 
ATOM   590  C CB  . PHE A 1 80  ? 132.656 156.594 168.053 1.00 22.51 ? 108 PHE A CB  1 
ATOM   591  C CG  . PHE A 1 80  ? 131.510 157.498 167.707 1.00 22.51 ? 108 PHE A CG  1 
ATOM   592  C CD1 . PHE A 1 80  ? 130.204 157.047 167.805 1.00 22.51 ? 108 PHE A CD1 1 
ATOM   593  C CD2 . PHE A 1 80  ? 131.738 158.792 167.267 1.00 22.51 ? 108 PHE A CD2 1 
ATOM   594  C CE1 . PHE A 1 80  ? 129.145 157.872 167.476 1.00 22.51 ? 108 PHE A CE1 1 
ATOM   595  C CE2 . PHE A 1 80  ? 130.686 159.623 166.938 1.00 22.51 ? 108 PHE A CE2 1 
ATOM   596  C CZ  . PHE A 1 80  ? 129.387 159.161 167.040 1.00 22.51 ? 108 PHE A CZ  1 
ATOM   597  N N   . TRP A 1 81  ? 134.387 154.276 169.324 1.00 17.49 ? 109 TRP A N   1 
ATOM   598  C CA  . TRP A 1 81  ? 135.428 153.271 169.142 1.00 17.49 ? 109 TRP A CA  1 
ATOM   599  C C   . TRP A 1 81  ? 134.959 151.894 169.599 1.00 17.49 ? 109 TRP A C   1 
ATOM   600  O O   . TRP A 1 81  ? 135.096 150.899 168.871 1.00 17.49 ? 109 TRP A O   1 
ATOM   601  C CB  . TRP A 1 81  ? 136.671 153.721 169.907 1.00 17.49 ? 109 TRP A CB  1 
ATOM   602  C CG  . TRP A 1 81  ? 137.855 152.838 169.806 1.00 17.49 ? 109 TRP A CG  1 
ATOM   603  C CD1 . TRP A 1 81  ? 138.724 152.750 168.763 1.00 17.49 ? 109 TRP A CD1 1 
ATOM   604  C CD2 . TRP A 1 81  ? 138.346 151.954 170.816 1.00 17.49 ? 109 TRP A CD2 1 
ATOM   605  N NE1 . TRP A 1 81  ? 139.715 151.845 169.049 1.00 17.49 ? 109 TRP A NE1 1 
ATOM   606  C CE2 . TRP A 1 81  ? 139.505 151.342 170.306 1.00 17.49 ? 109 TRP A CE2 1 
ATOM   607  C CE3 . TRP A 1 81  ? 137.909 151.610 172.098 1.00 17.49 ? 109 TRP A CE3 1 
ATOM   608  C CZ2 . TRP A 1 81  ? 140.235 150.405 171.032 1.00 17.49 ? 109 TRP A CZ2 1 
ATOM   609  C CZ3 . TRP A 1 81  ? 138.633 150.681 172.818 1.00 17.49 ? 109 TRP A CZ3 1 
ATOM   610  C CH2 . TRP A 1 81  ? 139.783 150.088 172.284 1.00 17.49 ? 109 TRP A CH2 1 
ATOM   611  N N   . THR A 1 82  ? 134.384 151.822 170.803 1.00 15.12 ? 110 THR A N   1 
ATOM   612  C CA  . THR A 1 82  ? 133.902 150.539 171.305 1.00 15.12 ? 110 THR A CA  1 
ATOM   613  C C   . THR A 1 82  ? 132.799 149.978 170.417 1.00 15.12 ? 110 THR A C   1 
ATOM   614  O O   . THR A 1 82  ? 132.784 148.777 170.112 1.00 15.12 ? 110 THR A O   1 
ATOM   615  C CB  . THR A 1 82  ? 133.406 150.680 172.743 1.00 15.12 ? 110 THR A CB  1 
ATOM   616  O OG1 . THR A 1 82  ? 132.322 151.615 172.785 1.00 15.12 ? 110 THR A OG1 1 
ATOM   617  C CG2 . THR A 1 82  ? 134.524 151.157 173.650 1.00 15.12 ? 110 THR A CG2 1 
ATOM   618  N N   . SER A 1 83  ? 131.869 150.832 169.983 1.00 12.83 ? 111 SER A N   1 
ATOM   619  C CA  . SER A 1 83  ? 130.773 150.350 169.155 1.00 12.83 ? 111 SER A CA  1 
ATOM   620  C C   . SER A 1 83  ? 131.271 149.880 167.796 1.00 12.83 ? 111 SER A C   1 
ATOM   621  O O   . SER A 1 83  ? 130.760 148.897 167.251 1.00 12.83 ? 111 SER A O   1 
ATOM   622  C CB  . SER A 1 83  ? 129.716 151.438 168.996 1.00 12.83 ? 111 SER A CB  1 
ATOM   623  O OG  . SER A 1 83  ? 128.599 150.940 168.289 1.00 12.83 ? 111 SER A OG  1 
ATOM   624  N N   . ILE A 1 84  ? 132.264 150.566 167.229 1.00 11.26 ? 112 ILE A N   1 
ATOM   625  C CA  . ILE A 1 84  ? 132.826 150.130 165.954 1.00 11.26 ? 112 ILE A CA  1 
ATOM   626  C C   . ILE A 1 84  ? 133.483 148.765 166.104 1.00 11.26 ? 112 ILE A C   1 
ATOM   627  O O   . ILE A 1 84  ? 133.327 147.884 165.249 1.00 11.26 ? 112 ILE A O   1 
ATOM   628  C CB  . ILE A 1 84  ? 133.815 151.175 165.411 1.00 11.26 ? 112 ILE A CB  1 
ATOM   629  C CG1 . ILE A 1 84  ? 133.063 152.318 164.728 1.00 11.26 ? 112 ILE A CG1 1 
ATOM   630  C CG2 . ILE A 1 84  ? 134.788 150.531 164.447 1.00 11.26 ? 112 ILE A CG2 1 
ATOM   631  C CD1 . ILE A 1 84  ? 133.946 153.490 164.351 1.00 11.26 ? 112 ILE A CD1 1 
ATOM   632  N N   . ASP A 1 85  ? 134.229 148.567 167.193 1.00 10.28 ? 113 ASP A N   1 
ATOM   633  C CA  . ASP A 1 85  ? 134.857 147.266 167.420 1.00 10.28 ? 113 ASP A CA  1 
ATOM   634  C C   . ASP A 1 85  ? 133.808 146.160 167.541 1.00 10.28 ? 113 ASP A C   1 
ATOM   635  O O   . ASP A 1 85  ? 133.935 145.082 166.935 1.00 10.28 ? 113 ASP A O   1 
ATOM   636  C CB  . ASP A 1 85  ? 135.725 147.329 168.676 1.00 10.28 ? 113 ASP A CB  1 
ATOM   637  C CG  . ASP A 1 85  ? 136.689 146.173 168.775 1.00 10.28 ? 113 ASP A CG  1 
ATOM   638  O OD1 . ASP A 1 85  ? 136.699 145.325 167.861 1.00 10.28 ? 113 ASP A OD1 1 
ATOM   639  O OD2 . ASP A 1 85  ? 137.437 146.110 169.773 1.00 10.28 ? 113 ASP A OD2 1 
ATOM   640  N N   . VAL A 1 86  ? 132.752 146.425 168.313 1.00 7.98  ? 114 VAL A N   1 
ATOM   641  C CA  . VAL A 1 86  ? 131.689 145.441 168.497 1.00 7.98  ? 114 VAL A CA  1 
ATOM   642  C C   . VAL A 1 86  ? 131.023 145.117 167.164 1.00 7.98  ? 114 VAL A C   1 
ATOM   643  O O   . VAL A 1 86  ? 130.774 143.948 166.840 1.00 7.98  ? 114 VAL A O   1 
ATOM   644  C CB  . VAL A 1 86  ? 130.670 145.953 169.530 1.00 7.98  ? 114 VAL A CB  1 
ATOM   645  C CG1 . VAL A 1 86  ? 129.373 145.174 169.434 1.00 7.98  ? 114 VAL A CG1 1 
ATOM   646  C CG2 . VAL A 1 86  ? 131.250 145.866 170.929 1.00 7.98  ? 114 VAL A CG2 1 
ATOM   647  N N   . LEU A 1 87  ? 130.724 146.151 166.374 1.00 8.40  ? 115 LEU A N   1 
ATOM   648  C CA  . LEU A 1 87  ? 130.132 145.948 165.057 1.00 8.40  ? 115 LEU A CA  1 
ATOM   649  C C   . LEU A 1 87  ? 131.018 145.100 164.165 1.00 8.40  ? 115 LEU A C   1 
ATOM   650  O O   . LEU A 1 87  ? 130.527 144.213 163.461 1.00 8.40  ? 115 LEU A O   1 
ATOM   651  C CB  . LEU A 1 87  ? 129.861 147.289 164.386 1.00 8.40  ? 115 LEU A CB  1 
ATOM   652  C CG  . LEU A 1 87  ? 129.221 147.120 163.012 1.00 8.40  ? 115 LEU A CG  1 
ATOM   653  C CD1 . LEU A 1 87  ? 127.835 146.571 163.164 1.00 8.40  ? 115 LEU A CD1 1 
ATOM   654  C CD2 . LEU A 1 87  ? 129.204 148.438 162.255 1.00 8.40  ? 115 LEU A CD2 1 
ATOM   655  N N   . CYS A 1 88  ? 132.320 145.370 164.162 1.00 9.13  ? 116 CYS A N   1 
ATOM   656  C CA  . CYS A 1 88  ? 133.210 144.624 163.285 1.00 9.13  ? 116 CYS A CA  1 
ATOM   657  C C   . CYS A 1 88  ? 133.236 143.149 163.664 1.00 9.13  ? 116 CYS A C   1 
ATOM   658  O O   . CYS A 1 88  ? 133.152 142.275 162.793 1.00 9.13  ? 116 CYS A O   1 
ATOM   659  C CB  . CYS A 1 88  ? 134.603 145.235 163.324 1.00 9.13  ? 116 CYS A CB  1 
ATOM   660  S SG  . CYS A 1 88  ? 134.640 146.857 162.542 1.00 9.13  ? 116 CYS A SG  1 
ATOM   661  N N   . VAL A 1 89  ? 133.303 142.847 164.963 1.00 6.80  ? 117 VAL A N   1 
ATOM   662  C CA  . VAL A 1 89  ? 133.323 141.437 165.360 1.00 6.80  ? 117 VAL A CA  1 
ATOM   663  C C   . VAL A 1 89  ? 132.000 140.754 165.019 1.00 6.80  ? 117 VAL A C   1 
ATOM   664  O O   . VAL A 1 89  ? 131.982 139.637 164.481 1.00 6.80  ? 117 VAL A O   1 
ATOM   665  C CB  . VAL A 1 89  ? 133.664 141.293 166.851 1.00 6.80  ? 117 VAL A CB  1 
ATOM   666  C CG1 . VAL A 1 89  ? 133.573 139.839 167.260 1.00 6.80  ? 117 VAL A CG1 1 
ATOM   667  C CG2 . VAL A 1 89  ? 135.055 141.824 167.119 1.00 6.80  ? 117 VAL A CG2 1 
ATOM   668  N N   . THR A 1 90  ? 130.873 141.407 165.318 1.00 5.01  ? 118 THR A N   1 
ATOM   669  C CA  . THR A 1 90  ? 129.577 140.777 165.072 1.00 5.01  ? 118 THR A CA  1 
ATOM   670  C C   . THR A 1 90  ? 129.323 140.571 163.579 1.00 5.01  ? 118 THR A C   1 
ATOM   671  O O   . THR A 1 90  ? 128.771 139.538 163.169 1.00 5.01  ? 118 THR A O   1 
ATOM   672  C CB  . THR A 1 90  ? 128.462 141.609 165.703 1.00 5.01  ? 118 THR A CB  1 
ATOM   673  O OG1 . THR A 1 90  ? 128.597 141.580 167.128 1.00 5.01  ? 118 THR A OG1 1 
ATOM   674  C CG2 . THR A 1 90  ? 127.104 141.053 165.330 1.00 5.01  ? 118 THR A CG2 1 
ATOM   675  N N   . ALA A 1 91  ? 129.713 141.537 162.750 1.00 4.84  ? 119 ALA A N   1 
ATOM   676  C CA  . ALA A 1 91  ? 129.555 141.435 161.308 1.00 4.84  ? 119 ALA A CA  1 
ATOM   677  C C   . ALA A 1 91  ? 130.578 140.516 160.665 1.00 4.84  ? 119 ALA A C   1 
ATOM   678  O O   . ALA A 1 91  ? 130.386 140.109 159.517 1.00 4.84  ? 119 ALA A O   1 
ATOM   679  C CB  . ALA A 1 91  ? 129.640 142.821 160.669 1.00 4.84  ? 119 ALA A CB  1 
ATOM   680  N N   . SER A 1 92  ? 131.664 140.192 161.357 1.00 4.16  ? 120 SER A N   1 
ATOM   681  C CA  . SER A 1 92  ? 132.535 139.128 160.891 1.00 4.16  ? 120 SER A CA  1 
ATOM   682  C C   . SER A 1 92  ? 132.042 137.748 161.309 1.00 4.16  ? 120 SER A C   1 
ATOM   683  O O   . SER A 1 92  ? 132.384 136.761 160.651 1.00 4.16  ? 120 SER A O   1 
ATOM   684  C CB  . SER A 1 92  ? 133.959 139.349 161.403 1.00 4.16  ? 120 SER A CB  1 
ATOM   685  O OG  . SER A 1 92  ? 134.808 138.283 161.024 1.00 4.16  ? 120 SER A OG  1 
ATOM   686  N N   . ILE A 1 93  ? 131.255 137.654 162.382 1.00 4.40  ? 121 ILE A N   1 
ATOM   687  C CA  . ILE A 1 93  ? 130.605 136.394 162.745 1.00 4.40  ? 121 ILE A CA  1 
ATOM   688  C C   . ILE A 1 93  ? 129.460 136.055 161.804 1.00 4.40  ? 121 ILE A C   1 
ATOM   689  O O   . ILE A 1 93  ? 129.440 134.983 161.183 1.00 4.40  ? 121 ILE A O   1 
ATOM   690  C CB  . ILE A 1 93  ? 130.070 136.421 164.185 1.00 4.40  ? 121 ILE A CB  1 
ATOM   691  C CG1 . ILE A 1 93  ? 131.195 136.580 165.188 1.00 4.40  ? 121 ILE A CG1 1 
ATOM   692  C CG2 . ILE A 1 93  ? 129.338 135.145 164.473 1.00 4.40  ? 121 ILE A CG2 1 
ATOM   693  C CD1 . ILE A 1 93  ? 132.122 135.427 165.150 1.00 4.40  ? 121 ILE A CD1 1 
ATOM   694  N N   . GLU A 1 94  ? 128.476 136.948 161.723 1.00 5.36  ? 122 GLU A N   1 
ATOM   695  C CA  . GLU A 1 94  ? 127.239 136.578 161.046 1.00 5.36  ? 122 GLU A CA  1 
ATOM   696  C C   . GLU A 1 94  ? 127.443 136.409 159.546 1.00 5.36  ? 122 GLU A C   1 
ATOM   697  O O   . GLU A 1 94  ? 126.725 135.631 158.913 1.00 5.36  ? 122 GLU A O   1 
ATOM   698  C CB  . GLU A 1 94  ? 126.145 137.599 161.345 1.00 5.36  ? 122 GLU A CB  1 
ATOM   699  C CG  . GLU A 1 94  ? 125.727 137.598 162.806 1.00 5.36  ? 122 GLU A CG  1 
ATOM   700  C CD  . GLU A 1 94  ? 124.257 137.902 163.002 1.00 5.36  ? 122 GLU A CD  1 
ATOM   701  O OE1 . GLU A 1 94  ? 123.505 137.873 162.006 1.00 5.36  ? 122 GLU A OE1 1 
ATOM   702  O OE2 . GLU A 1 94  ? 123.853 138.168 164.154 1.00 5.36  ? 122 GLU A OE2 1 
ATOM   703  N N   . THR A 1 95  ? 128.426 137.096 158.961 1.00 5.40  ? 123 THR A N   1 
ATOM   704  C CA  . THR A 1 95  ? 128.755 136.847 157.560 1.00 5.40  ? 123 THR A CA  1 
ATOM   705  C C   . THR A 1 95  ? 129.290 135.434 157.362 1.00 5.40  ? 123 THR A C   1 
ATOM   706  O O   . THR A 1 95  ? 128.955 134.769 156.376 1.00 5.40  ? 123 THR A O   1 
ATOM   707  C CB  . THR A 1 95  ? 129.760 137.880 157.057 1.00 5.40  ? 123 THR A CB  1 
ATOM   708  O OG1 . THR A 1 95  ? 129.133 139.166 157.000 1.00 5.40  ? 123 THR A OG1 1 
ATOM   709  C CG2 . THR A 1 95  ? 130.261 137.510 155.679 1.00 5.40  ? 123 THR A CG2 1 
ATOM   710  N N   . LEU A 1 96  ? 130.118 134.953 158.292 1.00 4.75  ? 124 LEU A N   1 
ATOM   711  C CA  . LEU A 1 96  ? 130.597 133.575 158.212 1.00 4.75  ? 124 LEU A CA  1 
ATOM   712  C C   . LEU A 1 96  ? 129.453 132.582 158.376 1.00 4.75  ? 124 LEU A C   1 
ATOM   713  O O   . LEU A 1 96  ? 129.408 131.551 157.693 1.00 4.75  ? 124 LEU A O   1 
ATOM   714  C CB  . LEU A 1 96  ? 131.678 133.336 159.262 1.00 4.75  ? 124 LEU A CB  1 
ATOM   715  C CG  . LEU A 1 96  ? 133.058 133.858 158.876 1.00 4.75  ? 124 LEU A CG  1 
ATOM   716  C CD1 . LEU A 1 96  ? 134.074 133.520 159.941 1.00 4.75  ? 124 LEU A CD1 1 
ATOM   717  C CD2 . LEU A 1 96  ? 133.478 133.278 157.542 1.00 4.75  ? 124 LEU A CD2 1 
ATOM   718  N N   . CYS A 1 97  ? 128.516 132.877 159.276 1.00 3.46  ? 125 CYS A N   1 
ATOM   719  C CA  . CYS A 1 97  ? 127.345 132.013 159.416 1.00 3.46  ? 125 CYS A CA  1 
ATOM   720  C C   . CYS A 1 97  ? 126.520 131.983 158.130 1.00 3.46  ? 125 CYS A C   1 
ATOM   721  O O   . CYS A 1 97  ? 126.036 130.920 157.710 1.00 3.46  ? 125 CYS A O   1 
ATOM   722  C CB  . CYS A 1 97  ? 126.487 132.475 160.590 1.00 3.46  ? 125 CYS A CB  1 
ATOM   723  S SG  . CYS A 1 97  ? 124.828 131.772 160.613 1.00 3.46  ? 125 CYS A SG  1 
ATOM   724  N N   . VAL A 1 98  ? 126.352 133.143 157.491 1.00 4.20  ? 126 VAL A N   1 
ATOM   725  C CA  . VAL A 1 98  ? 125.614 133.216 156.232 1.00 4.20  ? 126 VAL A CA  1 
ATOM   726  C C   . VAL A 1 98  ? 126.323 132.421 155.145 1.00 4.20  ? 126 VAL A C   1 
ATOM   727  O O   . VAL A 1 98  ? 125.681 131.715 154.362 1.00 4.20  ? 126 VAL A O   1 
ATOM   728  C CB  . VAL A 1 98  ? 125.408 134.682 155.814 1.00 4.20  ? 126 VAL A CB  1 
ATOM   729  C CG1 . VAL A 1 98  ? 124.956 134.756 154.376 1.00 4.20  ? 126 VAL A CG1 1 
ATOM   730  C CG2 . VAL A 1 98  ? 124.386 135.345 156.715 1.00 4.20  ? 126 VAL A CG2 1 
ATOM   731  N N   . ILE A 1 99  ? 127.651 132.531 155.068 1.00 2.24  ? 127 ILE A N   1 
ATOM   732  C CA  . ILE A 1 99  ? 128.405 131.742 154.096 1.00 2.24  ? 127 ILE A CA  1 
ATOM   733  C C   . ILE A 1 99  ? 128.204 130.255 154.347 1.00 2.24  ? 127 ILE A C   1 
ATOM   734  O O   . ILE A 1 99  ? 128.042 129.470 153.405 1.00 2.24  ? 127 ILE A O   1 
ATOM   735  C CB  . ILE A 1 99  ? 129.897 132.113 154.130 1.00 2.24  ? 127 ILE A CB  1 
ATOM   736  C CG1 . ILE A 1 99  ? 130.130 133.453 153.453 1.00 2.24  ? 127 ILE A CG1 1 
ATOM   737  C CG2 . ILE A 1 99  ? 130.726 131.053 153.448 1.00 2.24  ? 127 ILE A CG2 1 
ATOM   738  C CD1 . ILE A 1 99  ? 131.578 133.878 153.453 1.00 2.24  ? 127 ILE A CD1 1 
ATOM   739  N N   . ALA A 1 100 ? 128.225 129.838 155.615 1.00 3.98  ? 128 ALA A N   1 
ATOM   740  C CA  . ALA A 1 100 ? 128.039 128.424 155.927 1.00 3.98  ? 128 ALA A CA  1 
ATOM   741  C C   . ALA A 1 100 ? 126.676 127.926 155.461 1.00 3.98  ? 128 ALA A C   1 
ATOM   742  O O   . ALA A 1 100 ? 126.574 126.877 154.815 1.00 3.98  ? 128 ALA A O   1 
ATOM   743  C CB  . ALA A 1 100 ? 128.211 128.191 157.425 1.00 3.98  ? 128 ALA A CB  1 
ATOM   744  N N   . VAL A 1 101 ? 125.614 128.675 155.760 1.00 4.44  ? 129 VAL A N   1 
ATOM   745  C CA  . VAL A 1 101 ? 124.279 128.231 155.353 1.00 4.44  ? 129 VAL A CA  1 
ATOM   746  C C   . VAL A 1 101 ? 124.130 128.268 153.831 1.00 4.44  ? 129 VAL A C   1 
ATOM   747  O O   . VAL A 1 101 ? 123.489 127.393 153.230 1.00 4.44  ? 129 VAL A O   1 
ATOM   748  C CB  . VAL A 1 101 ? 123.200 129.070 156.056 1.00 4.44  ? 129 VAL A CB  1 
ATOM   749  C CG1 . VAL A 1 101 ? 121.830 128.783 155.465 1.00 4.44  ? 129 VAL A CG1 1 
ATOM   750  C CG2 . VAL A 1 101 ? 123.206 128.775 157.544 1.00 4.44  ? 129 VAL A CG2 1 
ATOM   751  N N   . ASP A 1 102 ? 124.713 129.281 153.187 1.00 5.28  ? 130 ASP A N   1 
ATOM   752  C CA  . ASP A 1 102 ? 124.721 129.349 151.729 1.00 5.28  ? 130 ASP A CA  1 
ATOM   753  C C   . ASP A 1 102 ? 125.356 128.106 151.130 1.00 5.28  ? 130 ASP A C   1 
ATOM   754  O O   . ASP A 1 102 ? 124.782 127.465 150.244 1.00 5.28  ? 130 ASP A O   1 
ATOM   755  C CB  . ASP A 1 102 ? 125.480 130.598 151.284 1.00 5.28  ? 130 ASP A CB  1 
ATOM   756  C CG  . ASP A 1 102 ? 125.672 130.668 149.787 1.00 5.28  ? 130 ASP A CG  1 
ATOM   757  O OD1 . ASP A 1 102 ? 124.929 129.997 149.048 1.00 5.28  ? 130 ASP A OD1 1 
ATOM   758  O OD2 . ASP A 1 102 ? 126.591 131.388 149.348 1.00 5.28  ? 130 ASP A OD2 1 
ATOM   759  N N   . ARG A 1 103 ? 126.550 127.756 151.596 1.00 5.04  ? 131 ARG A N   1 
ATOM   760  C CA  . ARG A 1 103 ? 127.226 126.580 151.076 1.00 5.04  ? 131 ARG A CA  1 
ATOM   761  C C   . ARG A 1 103 ? 126.484 125.299 151.434 1.00 5.04  ? 131 ARG A C   1 
ATOM   762  O O   . ARG A 1 103 ? 126.620 124.299 150.722 1.00 5.04  ? 131 ARG A O   1 
ATOM   763  C CB  . ARG A 1 103 ? 128.667 126.555 151.585 1.00 5.04  ? 131 ARG A CB  1 
ATOM   764  C CG  . ARG A 1 103 ? 129.503 125.417 151.057 1.00 5.04  ? 131 ARG A CG  1 
ATOM   765  C CD  . ARG A 1 103 ? 129.558 125.452 149.546 1.00 5.04  ? 131 ARG A CD  1 
ATOM   766  N NE  . ARG A 1 103 ? 130.210 126.649 149.032 1.00 5.04  ? 131 ARG A NE  1 
ATOM   767  C CZ  . ARG A 1 103 ? 130.156 127.030 147.760 1.00 5.04  ? 131 ARG A CZ  1 
ATOM   768  N NH1 . ARG A 1 103 ? 129.481 126.307 146.880 1.00 5.04  ? 131 ARG A NH1 1 
ATOM   769  N NH2 . ARG A 1 103 ? 130.775 128.131 147.365 1.00 5.04  ? 131 ARG A NH2 1 
ATOM   770  N N   . TYR A 1 104 ? 125.692 125.308 152.508 1.00 5.63  ? 132 TYR A N   1 
ATOM   771  C CA  . TYR A 1 104 ? 124.882 124.133 152.818 1.00 5.63  ? 132 TYR A CA  1 
ATOM   772  C C   . TYR A 1 104 ? 123.749 123.955 151.816 1.00 5.63  ? 132 TYR A C   1 
ATOM   773  O O   . TYR A 1 104 ? 123.476 122.833 151.376 1.00 5.63  ? 132 TYR A O   1 
ATOM   774  C CB  . TYR A 1 104 ? 124.322 124.227 154.232 1.00 5.63  ? 132 TYR A CB  1 
ATOM   775  C CG  . TYR A 1 104 ? 123.407 123.081 154.584 1.00 5.63  ? 132 TYR A CG  1 
ATOM   776  C CD1 . TYR A 1 104 ? 123.918 121.819 154.843 1.00 5.63  ? 132 TYR A CD1 1 
ATOM   777  C CD2 . TYR A 1 104 ? 122.035 123.259 154.653 1.00 5.63  ? 132 TYR A CD2 1 
ATOM   778  C CE1 . TYR A 1 104 ? 123.088 120.765 155.166 1.00 5.63  ? 132 TYR A CE1 1 
ATOM   779  C CE2 . TYR A 1 104 ? 121.195 122.212 154.973 1.00 5.63  ? 132 TYR A CE2 1 
ATOM   780  C CZ  . TYR A 1 104 ? 121.727 120.966 155.228 1.00 5.63  ? 132 TYR A CZ  1 
ATOM   781  O OH  . TYR A 1 104 ? 120.895 119.918 155.548 1.00 5.63  ? 132 TYR A OH  1 
ATOM   782  N N   . PHE A 1 105 ? 123.063 125.040 151.455 1.00 6.00  ? 133 PHE A N   1 
ATOM   783  C CA  . PHE A 1 105 ? 122.026 124.925 150.430 1.00 6.00  ? 133 PHE A CA  1 
ATOM   784  C C   . PHE A 1 105 ? 122.581 124.810 149.016 1.00 6.00  ? 133 PHE A C   1 
ATOM   785  O O   . PHE A 1 105 ? 121.835 124.428 148.109 1.00 6.00  ? 133 PHE A O   1 
ATOM   786  C CB  . PHE A 1 105 ? 121.047 126.102 150.483 1.00 6.00  ? 133 PHE A CB  1 
ATOM   787  C CG  . PHE A 1 105 ? 120.169 126.116 151.701 1.00 6.00  ? 133 PHE A CG  1 
ATOM   788  C CD1 . PHE A 1 105 ? 120.052 124.994 152.502 1.00 6.00  ? 133 PHE A CD1 1 
ATOM   789  C CD2 . PHE A 1 105 ? 119.444 127.249 152.031 1.00 6.00  ? 133 PHE A CD2 1 
ATOM   790  C CE1 . PHE A 1 105 ? 119.236 125.006 153.617 1.00 6.00  ? 133 PHE A CE1 1 
ATOM   791  C CE2 . PHE A 1 105 ? 118.628 127.266 153.145 1.00 6.00  ? 133 PHE A CE2 1 
ATOM   792  C CZ  . PHE A 1 105 ? 118.524 126.143 153.939 1.00 6.00  ? 133 PHE A CZ  1 
ATOM   793  N N   . ALA A 1 106 ? 123.853 125.124 148.800 1.00 5.82  ? 134 ALA A N   1 
ATOM   794  C CA  . ALA A 1 106 ? 124.447 124.995 147.477 1.00 5.82  ? 134 ALA A CA  1 
ATOM   795  C C   . ALA A 1 106 ? 125.016 123.610 147.218 1.00 5.82  ? 134 ALA A C   1 
ATOM   796  O O   . ALA A 1 106 ? 125.654 123.403 146.182 1.00 5.82  ? 134 ALA A O   1 
ATOM   797  C CB  . ALA A 1 106 ? 125.545 126.041 147.280 1.00 5.82  ? 134 ALA A CB  1 
ATOM   798  N N   . ILE A 1 107 ? 124.823 122.671 148.140 1.00 5.89  ? 135 ILE A N   1 
ATOM   799  C CA  . ILE A 1 107 ? 125.225 121.287 147.951 1.00 5.89  ? 135 ILE A CA  1 
ATOM   800  C C   . ILE A 1 107 ? 124.020 120.355 147.902 1.00 5.89  ? 135 ILE A C   1 
ATOM   801  O O   . ILE A 1 107 ? 124.006 119.393 147.131 1.00 5.89  ? 135 ILE A O   1 
ATOM   802  C CB  . ILE A 1 107 ? 126.219 120.853 149.051 1.00 5.89  ? 135 ILE A CB  1 
ATOM   803  C CG1 . ILE A 1 107 ? 127.521 121.642 148.920 1.00 5.89  ? 135 ILE A CG1 1 
ATOM   804  C CG2 . ILE A 1 107 ? 126.495 119.366 148.982 1.00 5.89  ? 135 ILE A CG2 1 
ATOM   805  C CD1 . ILE A 1 107 ? 128.641 121.117 149.779 1.00 5.89  ? 135 ILE A CD1 1 
ATOM   806  N N   . THR A 1 108 ? 122.992 120.636 148.705 1.00 7.54  ? 136 THR A N   1 
ATOM   807  C CA  . THR A 1 108 ? 121.791 119.808 148.694 1.00 7.54  ? 136 THR A CA  1 
ATOM   808  C C   . THR A 1 108 ? 121.099 119.845 147.337 1.00 7.54  ? 136 THR A C   1 
ATOM   809  O O   . THR A 1 108 ? 120.681 118.804 146.817 1.00 7.54  ? 136 THR A O   1 
ATOM   810  C CB  . THR A 1 108 ? 120.834 120.265 149.795 1.00 7.54  ? 136 THR A CB  1 
ATOM   811  O OG1 . THR A 1 108 ? 121.403 119.970 151.076 1.00 7.54  ? 136 THR A OG1 1 
ATOM   812  C CG2 . THR A 1 108 ? 119.488 119.568 149.666 1.00 7.54  ? 136 THR A CG2 1 
ATOM   813  N N   . SER A 1 109 ? 120.978 121.030 146.741 1.00 11.53 ? 137 SER A N   1 
ATOM   814  C CA  . SER A 1 109 ? 120.270 121.195 145.472 1.00 11.53 ? 137 SER A CA  1 
ATOM   815  C C   . SER A 1 109 ? 120.997 122.228 144.626 1.00 11.53 ? 137 SER A C   1 
ATOM   816  O O   . SER A 1 109 ? 120.694 123.426 144.684 1.00 11.53 ? 137 SER A O   1 
ATOM   817  C CB  . SER A 1 109 ? 118.815 121.603 145.703 1.00 11.53 ? 137 SER A CB  1 
ATOM   818  O OG  . SER A 1 109 ? 118.153 120.671 146.538 1.00 11.53 ? 137 SER A OG  1 
ATOM   819  N N   . PRO A 1 110 ? 121.970 121.795 143.819 1.00 11.39 ? 138 PRO A N   1 
ATOM   820  C CA  . PRO A 1 110 ? 122.757 122.772 143.043 1.00 11.39 ? 138 PRO A CA  1 
ATOM   821  C C   . PRO A 1 110 ? 121.923 123.599 142.079 1.00 11.39 ? 138 PRO A C   1 
ATOM   822  O O   . PRO A 1 110 ? 122.050 124.832 142.051 1.00 11.39 ? 138 PRO A O   1 
ATOM   823  C CB  . PRO A 1 110 ? 123.779 121.889 142.311 1.00 11.39 ? 138 PRO A CB  1 
ATOM   824  C CG  . PRO A 1 110 ? 123.832 120.619 143.090 1.00 11.39 ? 138 PRO A CG  1 
ATOM   825  C CD  . PRO A 1 110 ? 122.466 120.419 143.658 1.00 11.39 ? 138 PRO A CD  1 
ATOM   826  N N   . PHE A 1 111 ? 121.071 122.954 141.279 1.00 16.79 ? 139 PHE A N   1 
ATOM   827  C CA  . PHE A 1 111 ? 120.257 123.696 140.321 1.00 16.79 ? 139 PHE A CA  1 
ATOM   828  C C   . PHE A 1 111 ? 119.277 124.621 141.031 1.00 16.79 ? 139 PHE A C   1 
ATOM   829  O O   . PHE A 1 111 ? 119.073 125.765 140.606 1.00 16.79 ? 139 PHE A O   1 
ATOM   830  C CB  . PHE A 1 111 ? 119.525 122.729 139.386 1.00 16.79 ? 139 PHE A CB  1 
ATOM   831  C CG  . PHE A 1 111 ? 118.600 121.774 140.090 1.00 16.79 ? 139 PHE A CG  1 
ATOM   832  C CD1 . PHE A 1 111 ? 119.072 120.571 140.589 1.00 16.79 ? 139 PHE A CD1 1 
ATOM   833  C CD2 . PHE A 1 111 ? 117.254 122.069 140.235 1.00 16.79 ? 139 PHE A CD2 1 
ATOM   834  C CE1 . PHE A 1 111 ? 118.224 119.689 141.231 1.00 16.79 ? 139 PHE A CE1 1 
ATOM   835  C CE2 . PHE A 1 111 ? 116.402 121.192 140.878 1.00 16.79 ? 139 PHE A CE2 1 
ATOM   836  C CZ  . PHE A 1 111 ? 116.888 120.000 141.375 1.00 16.79 ? 139 PHE A CZ  1 
ATOM   837  N N   . LYS A 1 112 ? 118.668 124.148 142.120 1.00 16.72 ? 140 LYS A N   1 
ATOM   838  C CA  . LYS A 1 112 ? 117.748 124.993 142.874 1.00 16.72 ? 140 LYS A CA  1 
ATOM   839  C C   . LYS A 1 112 ? 118.468 126.194 143.474 1.00 16.72 ? 140 LYS A C   1 
ATOM   840  O O   . LYS A 1 112 ? 117.939 127.311 143.465 1.00 16.72 ? 140 LYS A O   1 
ATOM   841  C CB  . LYS A 1 112 ? 117.061 124.176 143.967 1.00 16.72 ? 140 LYS A CB  1 
ATOM   842  C CG  . LYS A 1 112 ? 115.729 123.581 143.549 1.00 16.72 ? 140 LYS A CG  1 
ATOM   843  C CD  . LYS A 1 112 ? 114.907 123.176 144.760 1.00 16.72 ? 140 LYS A CD  1 
ATOM   844  C CE  . LYS A 1 112 ? 113.479 122.836 144.369 1.00 16.72 ? 140 LYS A CE  1 
ATOM   845  N NZ  . LYS A 1 112 ? 112.604 122.660 145.561 1.00 16.72 ? 140 LYS A NZ  1 
ATOM   846  N N   . TYR A 1 113 ? 119.675 125.983 144.004 1.00 11.74 ? 141 TYR A N   1 
ATOM   847  C CA  . TYR A 1 113 ? 120.433 127.096 144.566 1.00 11.74 ? 141 TYR A CA  1 
ATOM   848  C C   . TYR A 1 113 ? 120.807 128.107 143.490 1.00 11.74 ? 141 TYR A C   1 
ATOM   849  O O   . TYR A 1 113 ? 120.692 129.319 143.701 1.00 11.74 ? 141 TYR A O   1 
ATOM   850  C CB  . TYR A 1 113 ? 121.684 126.578 145.277 1.00 11.74 ? 141 TYR A CB  1 
ATOM   851  C CG  . TYR A 1 113 ? 122.823 127.574 145.329 1.00 11.74 ? 141 TYR A CG  1 
ATOM   852  C CD1 . TYR A 1 113 ? 122.798 128.642 146.214 1.00 11.74 ? 141 TYR A CD1 1 
ATOM   853  C CD2 . TYR A 1 113 ? 123.924 127.443 144.494 1.00 11.74 ? 141 TYR A CD2 1 
ATOM   854  C CE1 . TYR A 1 113 ? 123.834 129.553 146.262 1.00 11.74 ? 141 TYR A CE1 1 
ATOM   855  C CE2 . TYR A 1 113 ? 124.966 128.349 144.539 1.00 11.74 ? 141 TYR A CE2 1 
ATOM   856  C CZ  . TYR A 1 113 ? 124.915 129.401 145.424 1.00 11.74 ? 141 TYR A CZ  1 
ATOM   857  O OH  . TYR A 1 113 ? 125.949 130.304 145.469 1.00 11.74 ? 141 TYR A OH  1 
ATOM   858  N N   . GLN A 1 114 ? 121.252 127.630 142.325 1.00 14.74 ? 142 GLN A N   1 
ATOM   859  C CA  . GLN A 1 114 ? 121.639 128.552 141.264 1.00 14.74 ? 142 GLN A CA  1 
ATOM   860  C C   . GLN A 1 114 ? 120.441 129.245 140.628 1.00 14.74 ? 142 GLN A C   1 
ATOM   861  O O   . GLN A 1 114 ? 120.604 130.318 140.038 1.00 14.74 ? 142 GLN A O   1 
ATOM   862  C CB  . GLN A 1 114 ? 122.448 127.820 140.192 1.00 14.74 ? 142 GLN A CB  1 
ATOM   863  C CG  . GLN A 1 114 ? 123.308 128.742 139.340 1.00 14.74 ? 142 GLN A CG  1 
ATOM   864  C CD  . GLN A 1 114 ? 124.204 127.990 138.379 1.00 14.74 ? 142 GLN A CD  1 
ATOM   865  O OE1 . GLN A 1 114 ? 124.244 126.761 138.383 1.00 14.74 ? 142 GLN A OE1 1 
ATOM   866  N NE2 . GLN A 1 114 ? 124.931 128.728 137.549 1.00 14.74 ? 142 GLN A NE2 1 
ATOM   867  N N   . SER A 1 115 ? 119.246 128.663 140.731 1.00 17.45 ? 143 SER A N   1 
ATOM   868  C CA  . SER A 1 115 ? 118.059 129.279 140.151 1.00 17.45 ? 143 SER A CA  1 
ATOM   869  C C   . SER A 1 115 ? 117.394 130.271 141.101 1.00 17.45 ? 143 SER A C   1 
ATOM   870  O O   . SER A 1 115 ? 117.053 131.387 140.698 1.00 17.45 ? 143 SER A O   1 
ATOM   871  C CB  . SER A 1 115 ? 117.058 128.196 139.739 1.00 17.45 ? 143 SER A CB  1 
ATOM   872  O OG  . SER A 1 115 ? 115.827 128.768 139.329 1.00 17.45 ? 143 SER A OG  1 
ATOM   873  N N   . LEU A 1 116 ? 117.200 129.878 142.361 1.00 17.86 ? 144 LEU A N   1 
ATOM   874  C CA  . LEU A 1 116 ? 116.446 130.715 143.288 1.00 17.86 ? 144 LEU A CA  1 
ATOM   875  C C   . LEU A 1 116 ? 117.257 131.922 143.744 1.00 17.86 ? 144 LEU A C   1 
ATOM   876  O O   . LEU A 1 116 ? 116.712 133.023 143.888 1.00 17.86 ? 144 LEU A O   1 
ATOM   877  C CB  . LEU A 1 116 ? 115.999 129.886 144.491 1.00 17.86 ? 144 LEU A CB  1 
ATOM   878  C CG  . LEU A 1 116 ? 115.065 128.709 144.198 1.00 17.86 ? 144 LEU A CG  1 
ATOM   879  C CD1 . LEU A 1 116 ? 114.813 127.896 145.458 1.00 17.86 ? 144 LEU A CD1 1 
ATOM   880  C CD2 . LEU A 1 116 ? 113.755 129.194 143.600 1.00 17.86 ? 144 LEU A CD2 1 
ATOM   881  N N   . LEU A 1 117 ? 118.553 131.741 143.974 1.00 14.34 ? 145 LEU A N   1 
ATOM   882  C CA  . LEU A 1 117 ? 119.392 132.768 144.576 1.00 14.34 ? 145 LEU A CA  1 
ATOM   883  C C   . LEU A 1 117 ? 120.217 133.479 143.510 1.00 14.34 ? 145 LEU A C   1 
ATOM   884  O O   . LEU A 1 117 ? 120.819 132.838 142.643 1.00 14.34 ? 145 LEU A O   1 
ATOM   885  C CB  . LEU A 1 117 ? 120.310 132.155 145.635 1.00 14.34 ? 145 LEU A CB  1 
ATOM   886  C CG  . LEU A 1 117 ? 121.001 133.095 146.622 1.00 14.34 ? 145 LEU A CG  1 
ATOM   887  C CD1 . LEU A 1 117 ? 121.149 132.405 147.967 1.00 14.34 ? 145 LEU A CD1 1 
ATOM   888  C CD2 . LEU A 1 117 ? 122.356 133.537 146.101 1.00 14.34 ? 145 LEU A CD2 1 
ATOM   889  N N   . THR A 1 118 ? 120.244 134.807 143.587 1.00 14.65 ? 146 THR A N   1 
ATOM   890  C CA  . THR A 1 118 ? 120.987 135.635 142.646 1.00 14.65 ? 146 THR A CA  1 
ATOM   891  C C   . THR A 1 118 ? 121.677 136.746 143.431 1.00 14.65 ? 146 THR A C   1 
ATOM   892  O O   . THR A 1 118 ? 121.705 136.735 144.665 1.00 14.65 ? 146 THR A O   1 
ATOM   893  C CB  . THR A 1 118 ? 120.060 136.188 141.555 1.00 14.65 ? 146 THR A CB  1 
ATOM   894  O OG1 . THR A 1 118 ? 120.817 136.998 140.647 1.00 14.65 ? 146 THR A OG1 1 
ATOM   895  C CG2 . THR A 1 118 ? 118.953 137.026 142.174 1.00 14.65 ? 146 THR A CG2 1 
ATOM   896  N N   . LYS A 1 119 ? 122.238 137.717 142.706 1.00 13.84 ? 147 LYS A N   1 
ATOM   897  C CA  . LYS A 1 119 ? 122.955 138.809 143.357 1.00 13.84 ? 147 LYS A CA  1 
ATOM   898  C C   . LYS A 1 119 ? 122.023 139.697 144.171 1.00 13.84 ? 147 LYS A C   1 
ATOM   899  O O   . LYS A 1 119 ? 122.447 140.276 145.179 1.00 13.84 ? 147 LYS A O   1 
ATOM   900  C CB  . LYS A 1 119 ? 123.697 139.645 142.316 1.00 13.84 ? 147 LYS A CB  1 
ATOM   901  C CG  . LYS A 1 119 ? 124.576 138.835 141.388 1.00 13.84 ? 147 LYS A CG  1 
ATOM   902  C CD  . LYS A 1 119 ? 125.399 139.739 140.489 1.00 13.84 ? 147 LYS A CD  1 
ATOM   903  C CE  . LYS A 1 119 ? 126.008 138.954 139.344 1.00 13.84 ? 147 LYS A CE  1 
ATOM   904  N NZ  . LYS A 1 119 ? 126.777 137.781 139.842 1.00 13.84 ? 147 LYS A NZ  1 
ATOM   905  N N   . ASN A 1 120 ? 120.764 139.827 143.748 1.00 13.72 ? 148 ASN A N   1 
ATOM   906  C CA  . ASN A 1 120 ? 119.823 140.679 144.468 1.00 13.72 ? 148 ASN A CA  1 
ATOM   907  C C   . ASN A 1 120 ? 119.587 140.163 145.882 1.00 13.72 ? 148 ASN A C   1 
ATOM   908  O O   . ASN A 1 120 ? 119.662 140.924 146.855 1.00 13.72 ? 148 ASN A O   1 
ATOM   909  C CB  . ASN A 1 120 ? 118.507 140.767 143.697 1.00 13.72 ? 148 ASN A CB  1 
ATOM   910  C CG  . ASN A 1 120 ? 118.681 141.372 142.318 1.00 13.72 ? 148 ASN A CG  1 
ATOM   911  O OD1 . ASN A 1 120 ? 119.401 142.355 142.144 1.00 13.72 ? 148 ASN A OD1 1 
ATOM   912  N ND2 . ASN A 1 120 ? 118.024 140.782 141.326 1.00 13.72 ? 148 ASN A ND2 1 
ATOM   913  N N   . LYS A 1 121 ? 119.312 138.862 146.016 1.00 12.82 ? 149 LYS A N   1 
ATOM   914  C CA  . LYS A 1 121 ? 119.139 138.275 147.341 1.00 12.82 ? 149 LYS A CA  1 
ATOM   915  C C   . LYS A 1 121 ? 120.428 138.332 148.148 1.00 12.82 ? 149 LYS A C   1 
ATOM   916  O O   . LYS A 1 121 ? 120.386 138.509 149.372 1.00 12.82 ? 149 LYS A O   1 
ATOM   917  C CB  . LYS A 1 121 ? 118.652 136.833 147.220 1.00 12.82 ? 149 LYS A CB  1 
ATOM   918  C CG  . LYS A 1 121 ? 118.341 136.168 148.552 1.00 12.82 ? 149 LYS A CG  1 
ATOM   919  C CD  . LYS A 1 121 ? 117.173 136.842 149.253 1.00 12.82 ? 149 LYS A CD  1 
ATOM   920  C CE  . LYS A 1 121 ? 116.670 136.000 150.415 1.00 12.82 ? 149 LYS A CE  1 
ATOM   921  N NZ  . LYS A 1 121 ? 115.500 136.622 151.094 1.00 12.82 ? 149 LYS A NZ  1 
ATOM   922  N N   . ALA A 1 122 ? 121.578 138.185 147.486 1.00 11.50 ? 150 ALA A N   1 
ATOM   923  C CA  . ALA A 1 122 ? 122.857 138.311 148.175 1.00 11.50 ? 150 ALA A CA  1 
ATOM   924  C C   . ALA A 1 122 ? 122.996 139.680 148.824 1.00 11.50 ? 150 ALA A C   1 
ATOM   925  O O   . ALA A 1 122 ? 123.287 139.788 150.022 1.00 11.50 ? 150 ALA A O   1 
ATOM   926  C CB  . ALA A 1 122 ? 124.004 138.068 147.197 1.00 11.50 ? 150 ALA A CB  1 
ATOM   927  N N   . ARG A 1 123 ? 122.783 140.742 148.045 1.00 11.02 ? 151 ARG A N   1 
ATOM   928  C CA  . ARG A 1 123 ? 122.888 142.087 148.596 1.00 11.02 ? 151 ARG A CA  1 
ATOM   929  C C   . ARG A 1 123 ? 121.833 142.323 149.668 1.00 11.02 ? 151 ARG A C   1 
ATOM   930  O O   . ARG A 1 123 ? 122.107 142.973 150.684 1.00 11.02 ? 151 ARG A O   1 
ATOM   931  C CB  . ARG A 1 123 ? 122.772 143.126 147.483 1.00 11.02 ? 151 ARG A CB  1 
ATOM   932  C CG  . ARG A 1 123 ? 123.040 144.559 147.928 1.00 11.02 ? 151 ARG A CG  1 
ATOM   933  C CD  . ARG A 1 123 ? 124.533 144.851 148.045 1.00 11.02 ? 151 ARG A CD  1 
ATOM   934  N NE  . ARG A 1 123 ? 124.954 145.047 149.431 1.00 11.02 ? 151 ARG A NE  1 
ATOM   935  C CZ  . ARG A 1 123 ? 126.214 145.239 149.812 1.00 11.02 ? 151 ARG A CZ  1 
ATOM   936  N NH1 . ARG A 1 123 ? 127.187 145.258 148.912 1.00 11.02 ? 151 ARG A NH1 1 
ATOM   937  N NH2 . ARG A 1 123 ? 126.504 145.411 151.094 1.00 11.02 ? 151 ARG A NH2 1 
ATOM   938  N N   . VAL A 1 124 ? 120.626 141.787 149.473 1.00 10.78 ? 152 VAL A N   1 
ATOM   939  C CA  . VAL A 1 124 ? 119.562 141.992 150.453 1.00 10.78 ? 152 VAL A CA  1 
ATOM   940  C C   . VAL A 1 124 ? 119.945 141.381 151.796 1.00 10.78 ? 152 VAL A C   1 
ATOM   941  O O   . VAL A 1 124 ? 119.832 142.028 152.844 1.00 10.78 ? 152 VAL A O   1 
ATOM   942  C CB  . VAL A 1 124 ? 118.231 141.422 149.932 1.00 10.78 ? 152 VAL A CB  1 
ATOM   943  C CG1 . VAL A 1 124 ? 117.282 141.144 151.088 1.00 10.78 ? 152 VAL A CG1 1 
ATOM   944  C CG2 . VAL A 1 124 ? 117.600 142.389 148.949 1.00 10.78 ? 152 VAL A CG2 1 
ATOM   945  N N   . ILE A 1 125 ? 120.418 140.131 151.791 1.00 10.11 ? 153 ILE A N   1 
ATOM   946  C CA  . ILE A 1 125 ? 120.738 139.494 153.067 1.00 10.11 ? 153 ILE A CA  1 
ATOM   947  C C   . ILE A 1 125 ? 122.008 140.083 153.673 1.00 10.11 ? 153 ILE A C   1 
ATOM   948  O O   . ILE A 1 125 ? 122.122 140.178 154.902 1.00 10.11 ? 153 ILE A O   1 
ATOM   949  C CB  . ILE A 1 125 ? 120.828 137.961 152.932 1.00 10.11 ? 153 ILE A CB  1 
ATOM   950  C CG1 . ILE A 1 125 ? 121.938 137.543 151.971 1.00 10.11 ? 153 ILE A CG1 1 
ATOM   951  C CG2 . ILE A 1 125 ? 119.491 137.383 152.501 1.00 10.11 ? 153 ILE A CG2 1 
ATOM   952  C CD1 . ILE A 1 125 ? 122.066 136.044 151.840 1.00 10.11 ? 153 ILE A CD1 1 
ATOM   953  N N   . ILE A 1 126 ? 122.975 140.495 152.848 1.00 9.82  ? 154 ILE A N   1 
ATOM   954  C CA  . ILE A 1 126 ? 124.159 141.149 153.398 1.00 9.82  ? 154 ILE A CA  1 
ATOM   955  C C   . ILE A 1 126 ? 123.768 142.439 154.106 1.00 9.82  ? 154 ILE A C   1 
ATOM   956  O O   . ILE A 1 126 ? 124.206 142.707 155.233 1.00 9.82  ? 154 ILE A O   1 
ATOM   957  C CB  . ILE A 1 126 ? 125.200 141.403 152.293 1.00 9.82  ? 154 ILE A CB  1 
ATOM   958  C CG1 . ILE A 1 126 ? 125.920 140.108 151.932 1.00 9.82  ? 154 ILE A CG1 1 
ATOM   959  C CG2 . ILE A 1 126 ? 126.209 142.446 152.736 1.00 9.82  ? 154 ILE A CG2 1 
ATOM   960  C CD1 . ILE A 1 126 ? 127.069 140.302 150.972 1.00 9.82  ? 154 ILE A CD1 1 
ATOM   961  N N   . LEU A 1 127 ? 122.917 143.246 153.471 1.00 10.59 ? 155 LEU A N   1 
ATOM   962  C CA  . LEU A 1 127 ? 122.465 144.475 154.109 1.00 10.59 ? 155 LEU A CA  1 
ATOM   963  C C   . LEU A 1 127 ? 121.647 144.177 155.357 1.00 10.59 ? 155 LEU A C   1 
ATOM   964  O O   . LEU A 1 127 ? 121.750 144.894 156.356 1.00 10.59 ? 155 LEU A O   1 
ATOM   965  C CB  . LEU A 1 127 ? 121.661 145.317 153.120 1.00 10.59 ? 155 LEU A CB  1 
ATOM   966  C CG  . LEU A 1 127 ? 122.488 146.026 152.046 1.00 10.59 ? 155 LEU A CG  1 
ATOM   967  C CD1 . LEU A 1 127 ? 121.707 147.176 151.439 1.00 10.59 ? 155 LEU A CD1 1 
ATOM   968  C CD2 . LEU A 1 127 ? 123.808 146.516 152.620 1.00 10.59 ? 155 LEU A CD2 1 
ATOM   969  N N   . MET A 1 128 ? 120.836 143.118 155.325 1.00 9.71  ? 156 MET A N   1 
ATOM   970  C CA  . MET A 1 128 ? 120.021 142.784 156.488 1.00 9.71  ? 156 MET A CA  1 
ATOM   971  C C   . MET A 1 128 ? 120.890 142.402 157.682 1.00 9.71  ? 156 MET A C   1 
ATOM   972  O O   . MET A 1 128 ? 120.659 142.865 158.807 1.00 9.71  ? 156 MET A O   1 
ATOM   973  C CB  . MET A 1 128 ? 119.051 141.656 156.139 1.00 9.71  ? 156 MET A CB  1 
ATOM   974  C CG  . MET A 1 128 ? 118.077 141.320 157.253 1.00 9.71  ? 156 MET A CG  1 
ATOM   975  S SD  . MET A 1 128 ? 116.970 142.687 157.650 1.00 9.71  ? 156 MET A SD  1 
ATOM   976  C CE  . MET A 1 128 ? 115.893 142.679 156.220 1.00 9.71  ? 156 MET A CE  1 
ATOM   977  N N   . VAL A 1 129 ? 121.905 141.563 157.459 1.00 9.24  ? 157 VAL A N   1 
ATOM   978  C CA  . VAL A 1 129 ? 122.769 141.167 158.568 1.00 9.24  ? 157 VAL A CA  1 
ATOM   979  C C   . VAL A 1 129 ? 123.602 142.350 159.046 1.00 9.24  ? 157 VAL A C   1 
ATOM   980  O O   . VAL A 1 129 ? 123.855 142.496 160.248 1.00 9.24  ? 157 VAL A O   1 
ATOM   981  C CB  . VAL A 1 129 ? 123.647 139.957 158.191 1.00 9.24  ? 157 VAL A CB  1 
ATOM   982  C CG1 . VAL A 1 129 ? 122.778 138.785 157.761 1.00 9.24  ? 157 VAL A CG1 1 
ATOM   983  C CG2 . VAL A 1 129 ? 124.661 140.308 157.118 1.00 9.24  ? 157 VAL A CG2 1 
ATOM   984  N N   . TRP A 1 130 ? 124.029 143.224 158.127 1.00 10.41 ? 158 TRP A N   1 
ATOM   985  C CA  . TRP A 1 130 ? 124.774 144.405 158.549 1.00 10.41 ? 158 TRP A CA  1 
ATOM   986  C C   . TRP A 1 130 ? 123.908 145.336 159.388 1.00 10.41 ? 158 TRP A C   1 
ATOM   987  O O   . TRP A 1 130 ? 124.386 145.910 160.368 1.00 10.41 ? 158 TRP A O   1 
ATOM   988  C CB  . TRP A 1 130 ? 125.340 145.141 157.339 1.00 10.41 ? 158 TRP A CB  1 
ATOM   989  C CG  . TRP A 1 130 ? 126.758 144.785 157.046 1.00 10.41 ? 158 TRP A CG  1 
ATOM   990  C CD1 . TRP A 1 130 ? 127.210 143.996 156.033 1.00 10.41 ? 158 TRP A CD1 1 
ATOM   991  C CD2 . TRP A 1 130 ? 127.916 145.203 157.775 1.00 10.41 ? 158 TRP A CD2 1 
ATOM   992  N NE1 . TRP A 1 130 ? 128.578 143.897 156.082 1.00 10.41 ? 158 TRP A NE1 1 
ATOM   993  C CE2 . TRP A 1 130 ? 129.036 144.630 157.144 1.00 10.41 ? 158 TRP A CE2 1 
ATOM   994  C CE3 . TRP A 1 130 ? 128.115 146.007 158.899 1.00 10.41 ? 158 TRP A CE3 1 
ATOM   995  C CZ2 . TRP A 1 130 ? 130.333 144.836 157.596 1.00 10.41 ? 158 TRP A CZ2 1 
ATOM   996  C CZ3 . TRP A 1 130 ? 129.407 146.208 159.348 1.00 10.41 ? 158 TRP A CZ3 1 
ATOM   997  C CH2 . TRP A 1 130 ? 130.499 145.625 158.697 1.00 10.41 ? 158 TRP A CH2 1 
ATOM   998  N N   . ILE A 1 131 ? 122.631 145.490 159.030 1.00 9.52  ? 159 ILE A N   1 
ATOM   999  C CA  . ILE A 1 131 ? 121.737 146.335 159.817 1.00 9.52  ? 159 ILE A CA  1 
ATOM   1000 C C   . ILE A 1 131 ? 121.460 145.712 161.179 1.00 9.52  ? 159 ILE A C   1 
ATOM   1001 O O   . ILE A 1 131 ? 121.392 146.417 162.193 1.00 9.52  ? 159 ILE A O   1 
ATOM   1002 C CB  . ILE A 1 131 ? 120.434 146.614 159.045 1.00 9.52  ? 159 ILE A CB  1 
ATOM   1003 C CG1 . ILE A 1 131 ? 120.723 147.408 157.768 1.00 9.52  ? 159 ILE A CG1 1 
ATOM   1004 C CG2 . ILE A 1 131 ? 119.431 147.349 159.921 1.00 9.52  ? 159 ILE A CG2 1 
ATOM   1005 C CD1 . ILE A 1 131 ? 121.665 148.578 157.968 1.00 9.52  ? 159 ILE A CD1 1 
ATOM   1006 N N   . VAL A 1 132 ? 121.289 144.390 161.232 1.00 10.97 ? 160 VAL A N   1 
ATOM   1007 C CA  . VAL A 1 132 ? 121.064 143.730 162.519 1.00 10.97 ? 160 VAL A CA  1 
ATOM   1008 C C   . VAL A 1 132 ? 122.277 143.908 163.426 1.00 10.97 ? 160 VAL A C   1 
ATOM   1009 O O   . VAL A 1 132 ? 122.150 144.238 164.613 1.00 10.97 ? 160 VAL A O   1 
ATOM   1010 C CB  . VAL A 1 132 ? 120.723 142.245 162.310 1.00 10.97 ? 160 VAL A CB  1 
ATOM   1011 C CG1 . VAL A 1 132 ? 120.787 141.496 163.631 1.00 10.97 ? 160 VAL A CG1 1 
ATOM   1012 C CG2 . VAL A 1 132 ? 119.345 142.104 161.685 1.00 10.97 ? 160 VAL A CG2 1 
ATOM   1013 N N   . SER A 1 133 ? 123.475 143.703 162.872 1.00 10.64 ? 161 SER A N   1 
ATOM   1014 C CA  . SER A 1 133 ? 124.694 143.910 163.645 1.00 10.64 ? 161 SER A CA  1 
ATOM   1015 C C   . SER A 1 133 ? 124.838 145.366 164.073 1.00 10.64 ? 161 SER A C   1 
ATOM   1016 O O   . SER A 1 133 ? 125.250 145.652 165.203 1.00 10.64 ? 161 SER A O   1 
ATOM   1017 C CB  . SER A 1 133 ? 125.908 143.463 162.832 1.00 10.64 ? 161 SER A CB  1 
ATOM   1018 O OG  . SER A 1 133 ? 125.791 142.107 162.435 1.00 10.64 ? 161 SER A OG  1 
ATOM   1019 N N   . GLY A 1 134 ? 124.508 146.303 163.181 1.00 11.48 ? 162 GLY A N   1 
ATOM   1020 C CA  . GLY A 1 134 ? 124.598 147.710 163.529 1.00 11.48 ? 162 GLY A CA  1 
ATOM   1021 C C   . GLY A 1 134 ? 123.665 148.089 164.658 1.00 11.48 ? 162 GLY A C   1 
ATOM   1022 O O   . GLY A 1 134 ? 124.034 148.854 165.548 1.00 11.48 ? 162 GLY A O   1 
ATOM   1023 N N   . LEU A 1 135 ? 122.443 147.559 164.636 1.00 13.35 ? 163 LEU A N   1 
ATOM   1024 C CA  . LEU A 1 135 ? 121.519 147.797 165.738 1.00 13.35 ? 163 LEU A CA  1 
ATOM   1025 C C   . LEU A 1 135 ? 122.069 147.220 167.036 1.00 13.35 ? 163 LEU A C   1 
ATOM   1026 O O   . LEU A 1 135 ? 122.164 147.920 168.054 1.00 13.35 ? 163 LEU A O   1 
ATOM   1027 C CB  . LEU A 1 135 ? 120.154 147.193 165.408 1.00 13.35 ? 163 LEU A CB  1 
ATOM   1028 C CG  . LEU A 1 135 ? 119.089 147.241 166.503 1.00 13.35 ? 163 LEU A CG  1 
ATOM   1029 C CD1 . LEU A 1 135 ? 118.490 148.633 166.591 1.00 13.35 ? 163 LEU A CD1 1 
ATOM   1030 C CD2 . LEU A 1 135 ? 118.010 146.202 166.248 1.00 13.35 ? 163 LEU A CD2 1 
ATOM   1031 N N   . THR A 1 136 ? 122.476 145.946 167.006 1.00 13.68 ? 164 THR A N   1 
ATOM   1032 C CA  . THR A 1 136 ? 122.954 145.281 168.213 1.00 13.68 ? 164 THR A CA  1 
ATOM   1033 C C   . THR A 1 136 ? 124.253 145.888 168.734 1.00 13.68 ? 164 THR A C   1 
ATOM   1034 O O   . THR A 1 136 ? 124.610 145.667 169.896 1.00 13.68 ? 164 THR A O   1 
ATOM   1035 C CB  . THR A 1 136 ? 123.134 143.785 167.935 1.00 13.68 ? 164 THR A CB  1 
ATOM   1036 O OG1 . THR A 1 136 ? 121.976 143.289 167.254 1.00 13.68 ? 164 THR A OG1 1 
ATOM   1037 C CG2 . THR A 1 136 ? 123.296 143.005 169.230 1.00 13.68 ? 164 THR A CG2 1 
ATOM   1038 N N   . SER A 1 137 ? 124.968 146.648 167.907 1.00 13.34 ? 165 SER A N   1 
ATOM   1039 C CA  . SER A 1 137 ? 126.196 147.300 168.352 1.00 13.34 ? 165 SER A CA  1 
ATOM   1040 C C   . SER A 1 137 ? 125.938 148.721 168.849 1.00 13.34 ? 165 SER A C   1 
ATOM   1041 O O   . SER A 1 137 ? 126.470 149.130 169.885 1.00 13.34 ? 165 SER A O   1 
ATOM   1042 C CB  . SER A 1 137 ? 127.223 147.303 167.216 1.00 13.34 ? 165 SER A CB  1 
ATOM   1043 O OG  . SER A 1 137 ? 127.487 145.983 166.774 1.00 13.34 ? 165 SER A OG  1 
ATOM   1044 N N   . PHE A 1 138 ? 125.127 149.487 168.116 1.00 18.47 ? 166 PHE A N   1 
ATOM   1045 C CA  . PHE A 1 138 ? 124.878 150.877 168.479 1.00 18.47 ? 166 PHE A CA  1 
ATOM   1046 C C   . PHE A 1 138 ? 123.956 150.980 169.688 1.00 18.47 ? 166 PHE A C   1 
ATOM   1047 O O   . PHE A 1 138 ? 124.293 151.636 170.680 1.00 18.47 ? 166 PHE A O   1 
ATOM   1048 C CB  . PHE A 1 138 ? 124.275 151.629 167.291 1.00 18.47 ? 166 PHE A CB  1 
ATOM   1049 C CG  . PHE A 1 138 ? 125.287 152.107 166.288 1.00 18.47 ? 166 PHE A CG  1 
ATOM   1050 C CD1 . PHE A 1 138 ? 124.937 153.038 165.324 1.00 18.47 ? 166 PHE A CD1 1 
ATOM   1051 C CD2 . PHE A 1 138 ? 126.580 151.623 166.302 1.00 18.47 ? 166 PHE A CD2 1 
ATOM   1052 C CE1 . PHE A 1 138 ? 125.862 153.479 164.398 1.00 18.47 ? 166 PHE A CE1 1 
ATOM   1053 C CE2 . PHE A 1 138 ? 127.510 152.059 165.382 1.00 18.47 ? 166 PHE A CE2 1 
ATOM   1054 C CZ  . PHE A 1 138 ? 127.150 152.988 164.428 1.00 18.47 ? 166 PHE A CZ  1 
ATOM   1055 N N   . LEU A 1 139 ? 122.780 150.349 169.618 1.00 21.02 ? 167 LEU A N   1 
ATOM   1056 C CA  . LEU A 1 139 ? 121.745 150.611 170.617 1.00 21.02 ? 167 LEU A CA  1 
ATOM   1057 C C   . LEU A 1 139 ? 122.168 150.239 172.034 1.00 21.02 ? 167 LEU A C   1 
ATOM   1058 O O   . LEU A 1 139 ? 122.026 151.085 172.932 1.00 21.02 ? 167 LEU A O   1 
ATOM   1059 C CB  . LEU A 1 139 ? 120.448 149.905 170.195 1.00 21.02 ? 167 LEU A CB  1 
ATOM   1060 C CG  . LEU A 1 139 ? 119.112 150.198 170.894 1.00 21.02 ? 167 LEU A CG  1 
ATOM   1061 C CD1 . LEU A 1 139 ? 117.964 149.708 170.030 1.00 21.02 ? 167 LEU A CD1 1 
ATOM   1062 C CD2 . LEU A 1 139 ? 119.014 149.552 172.267 1.00 21.02 ? 167 LEU A CD2 1 
ATOM   1063 N N   . PRO A 1 140 ? 122.680 149.034 172.315 1.00 20.10 ? 168 PRO A N   1 
ATOM   1064 C CA  . PRO A 1 140 ? 122.996 148.700 173.715 1.00 20.10 ? 168 PRO A CA  1 
ATOM   1065 C C   . PRO A 1 140 ? 124.029 149.614 174.348 1.00 20.10 ? 168 PRO A C   1 
ATOM   1066 O O   . PRO A 1 140 ? 123.937 149.896 175.549 1.00 20.10 ? 168 PRO A O   1 
ATOM   1067 C CB  . PRO A 1 140 ? 123.504 147.255 173.623 1.00 20.10 ? 168 PRO A CB  1 
ATOM   1068 C CG  . PRO A 1 140 ? 122.916 146.731 172.369 1.00 20.10 ? 168 PRO A CG  1 
ATOM   1069 C CD  . PRO A 1 140 ? 122.933 147.888 171.426 1.00 20.10 ? 168 PRO A CD  1 
ATOM   1070 N N   . ILE A 1 141 ? 125.013 150.083 173.580 1.00 20.95 ? 169 ILE A N   1 
ATOM   1071 C CA  . ILE A 1 141 ? 126.022 150.979 174.135 1.00 20.95 ? 169 ILE A CA  1 
ATOM   1072 C C   . ILE A 1 141 ? 125.397 152.316 174.515 1.00 20.95 ? 169 ILE A C   1 
ATOM   1073 O O   . ILE A 1 141 ? 125.655 152.859 175.595 1.00 20.95 ? 169 ILE A O   1 
ATOM   1074 C CB  . ILE A 1 141 ? 127.184 151.160 173.141 1.00 20.95 ? 169 ILE A CB  1 
ATOM   1075 C CG1 . ILE A 1 141 ? 127.980 149.862 173.007 1.00 20.95 ? 169 ILE A CG1 1 
ATOM   1076 C CG2 . ILE A 1 141 ? 128.100 152.286 173.585 1.00 20.95 ? 169 ILE A CG2 1 
ATOM   1077 C CD1 . ILE A 1 141 ? 128.594 149.397 174.302 1.00 20.95 ? 169 ILE A CD1 1 
ATOM   1078 N N   . GLN A 1 142 ? 124.549 152.857 173.641 1.00 21.47 ? 170 GLN A N   1 
ATOM   1079 C CA  . GLN A 1 142 ? 124.021 154.202 173.821 1.00 21.47 ? 170 GLN A CA  1 
ATOM   1080 C C   . GLN A 1 142 ? 122.975 154.302 174.924 1.00 21.47 ? 170 GLN A C   1 
ATOM   1081 O O   . GLN A 1 142 ? 122.740 155.404 175.428 1.00 21.47 ? 170 GLN A O   1 
ATOM   1082 C CB  . GLN A 1 142 ? 123.430 154.709 172.504 1.00 21.47 ? 170 GLN A CB  1 
ATOM   1083 C CG  . GLN A 1 142 ? 124.469 154.939 171.417 1.00 21.47 ? 170 GLN A CG  1 
ATOM   1084 C CD  . GLN A 1 142 ? 125.610 155.827 171.878 1.00 21.47 ? 170 GLN A CD  1 
ATOM   1085 O OE1 . GLN A 1 142 ? 126.780 155.518 171.654 1.00 21.47 ? 170 GLN A OE1 1 
ATOM   1086 N NE2 . GLN A 1 142 ? 125.273 156.941 172.518 1.00 21.47 ? 170 GLN A NE2 1 
ATOM   1087 N N   . MET A 1 143 ? 122.346 153.197 175.312 1.00 21.01 ? 171 MET A N   1 
ATOM   1088 C CA  . MET A 1 143 ? 121.383 153.218 176.404 1.00 21.01 ? 171 MET A CA  1 
ATOM   1089 C C   . MET A 1 143 ? 122.036 153.046 177.767 1.00 21.01 ? 171 MET A C   1 
ATOM   1090 O O   . MET A 1 143 ? 121.327 153.020 178.779 1.00 21.01 ? 171 MET A O   1 
ATOM   1091 C CB  . MET A 1 143 ? 120.315 152.139 176.195 1.00 21.01 ? 171 MET A CB  1 
ATOM   1092 C CG  . MET A 1 143 ? 119.690 152.114 174.801 1.00 21.01 ? 171 MET A CG  1 
ATOM   1093 S SD  . MET A 1 143 ? 119.718 153.661 173.862 1.00 21.01 ? 171 MET A SD  1 
ATOM   1094 C CE  . MET A 1 143 ? 118.720 154.750 174.884 1.00 21.01 ? 171 MET A CE  1 
ATOM   1095 N N   . HIS A 1 144 ? 123.364 152.920 177.810 1.00 21.40 ? 172 HIS A N   1 
ATOM   1096 C CA  . HIS A 1 144 ? 124.133 152.924 179.054 1.00 21.40 ? 172 HIS A CA  1 
ATOM   1097 C C   . HIS A 1 144 ? 123.764 151.759 179.968 1.00 21.40 ? 172 HIS A C   1 
ATOM   1098 O O   . HIS A 1 144 ? 123.709 151.911 181.191 1.00 21.40 ? 172 HIS A O   1 
ATOM   1099 C CB  . HIS A 1 144 ? 123.975 154.253 179.800 1.00 21.40 ? 172 HIS A CB  1 
ATOM   1100 C CG  . HIS A 1 144 ? 124.529 155.432 179.062 1.00 21.40 ? 172 HIS A CG  1 
ATOM   1101 N ND1 . HIS A 1 144 ? 124.230 155.693 177.742 1.00 21.40 ? 172 HIS A ND1 1 
ATOM   1102 C CD2 . HIS A 1 144 ? 125.363 156.421 179.460 1.00 21.40 ? 172 HIS A CD2 1 
ATOM   1103 C CE1 . HIS A 1 144 ? 124.855 156.792 177.359 1.00 21.40 ? 172 HIS A CE1 1 
ATOM   1104 N NE2 . HIS A 1 144 ? 125.550 157.253 178.383 1.00 21.40 ? 172 HIS A NE2 1 
ATOM   1105 N N   . TRP A 1 145 ? 123.507 150.586 179.393 1.00 24.10 ? 173 TRP A N   1 
ATOM   1106 C CA  . TRP A 1 145 ? 123.286 149.395 180.203 1.00 24.10 ? 173 TRP A CA  1 
ATOM   1107 C C   . TRP A 1 145 ? 124.583 148.755 180.679 1.00 24.10 ? 173 TRP A C   1 
ATOM   1108 O O   . TRP A 1 145 ? 124.530 147.792 181.451 1.00 24.10 ? 173 TRP A O   1 
ATOM   1109 C CB  . TRP A 1 145 ? 122.454 148.364 179.436 1.00 24.10 ? 173 TRP A CB  1 
ATOM   1110 C CG  . TRP A 1 145 ? 121.069 148.827 179.097 1.00 24.10 ? 173 TRP A CG  1 
ATOM   1111 C CD1 . TRP A 1 145 ? 120.162 149.383 179.950 1.00 24.10 ? 173 TRP A CD1 1 
ATOM   1112 C CD2 . TRP A 1 145 ? 120.418 148.736 177.824 1.00 24.10 ? 173 TRP A CD2 1 
ATOM   1113 N NE1 . TRP A 1 145 ? 118.994 149.663 179.284 1.00 24.10 ? 173 TRP A NE1 1 
ATOM   1114 C CE2 . TRP A 1 145 ? 119.125 149.274 177.977 1.00 24.10 ? 173 TRP A CE2 1 
ATOM   1115 C CE3 . TRP A 1 145 ? 120.806 148.260 176.568 1.00 24.10 ? 173 TRP A CE3 1 
ATOM   1116 C CZ2 . TRP A 1 145 ? 118.219 149.350 176.923 1.00 24.10 ? 173 TRP A CZ2 1 
ATOM   1117 C CZ3 . TRP A 1 145 ? 119.904 148.336 175.523 1.00 24.10 ? 173 TRP A CZ3 1 
ATOM   1118 C CH2 . TRP A 1 145 ? 118.626 148.876 175.707 1.00 24.10 ? 173 TRP A CH2 1 
ATOM   1119 N N   . TYR A 1 146 ? 125.738 149.259 180.241 1.00 23.69 ? 174 TYR A N   1 
ATOM   1120 C CA  . TYR A 1 146 ? 127.013 148.764 180.746 1.00 23.69 ? 174 TYR A CA  1 
ATOM   1121 C C   . TYR A 1 146 ? 127.424 149.429 182.054 1.00 23.69 ? 174 TYR A C   1 
ATOM   1122 O O   . TYR A 1 146 ? 128.527 149.163 182.542 1.00 23.69 ? 174 TYR A O   1 
ATOM   1123 C CB  . TYR A 1 146 ? 128.102 148.939 179.681 1.00 23.69 ? 174 TYR A CB  1 
ATOM   1124 C CG  . TYR A 1 146 ? 128.348 150.366 179.234 1.00 23.69 ? 174 TYR A CG  1 
ATOM   1125 C CD1 . TYR A 1 146 ? 127.962 150.788 177.970 1.00 23.69 ? 174 TYR A CD1 1 
ATOM   1126 C CD2 . TYR A 1 146 ? 128.989 151.281 180.061 1.00 23.69 ? 174 TYR A CD2 1 
ATOM   1127 C CE1 . TYR A 1 146 ? 128.189 152.085 177.550 1.00 23.69 ? 174 TYR A CE1 1 
ATOM   1128 C CE2 . TYR A 1 146 ? 129.219 152.579 179.650 1.00 23.69 ? 174 TYR A CE2 1 
ATOM   1129 C CZ  . TYR A 1 146 ? 128.819 152.975 178.394 1.00 23.69 ? 174 TYR A CZ  1 
ATOM   1130 O OH  . TYR A 1 146 ? 129.049 154.268 177.982 1.00 23.69 ? 174 TYR A OH  1 
ATOM   1131 N N   . ARG A 1 147 ? 126.576 150.289 182.615 1.00 26.40 ? 175 ARG A N   1 
ATOM   1132 C CA  . ARG A 1 147 ? 126.883 150.944 183.879 1.00 26.40 ? 175 ARG A CA  1 
ATOM   1133 C C   . ARG A 1 147 ? 127.090 149.918 184.985 1.00 26.40 ? 175 ARG A C   1 
ATOM   1134 O O   . ARG A 1 147 ? 126.390 148.904 185.056 1.00 26.40 ? 175 ARG A O   1 
ATOM   1135 C CB  . ARG A 1 147 ? 125.753 151.901 184.262 1.00 26.40 ? 175 ARG A CB  1 
ATOM   1136 C CG  . ARG A 1 147 ? 126.108 152.884 185.366 1.00 26.40 ? 175 ARG A CG  1 
ATOM   1137 C CD  . ARG A 1 147 ? 124.906 153.730 185.764 1.00 26.40 ? 175 ARG A CD  1 
ATOM   1138 N NE  . ARG A 1 147 ? 124.621 154.777 184.788 1.00 26.40 ? 175 ARG A NE  1 
ATOM   1139 C CZ  . ARG A 1 147 ? 123.620 154.731 183.915 1.00 26.40 ? 175 ARG A CZ  1 
ATOM   1140 N NH1 . ARG A 1 147 ? 122.803 153.687 183.895 1.00 26.40 ? 175 ARG A NH1 1 
ATOM   1141 N NH2 . ARG A 1 147 ? 123.435 155.729 183.062 1.00 26.40 ? 175 ARG A NH2 1 
ATOM   1142 N N   . ALA A 1 148 ? 128.061 150.188 185.852 1.00 25.02 ? 176 ALA A N   1 
ATOM   1143 C CA  . ALA A 1 148 ? 128.365 149.333 186.987 1.00 25.02 ? 176 ALA A CA  1 
ATOM   1144 C C   . ALA A 1 148 ? 128.298 150.140 188.277 1.00 25.02 ? 176 ALA A C   1 
ATOM   1145 O O   . ALA A 1 148 ? 128.395 151.370 188.273 1.00 25.02 ? 176 ALA A O   1 
ATOM   1146 C CB  . ALA A 1 148 ? 129.749 148.685 186.844 1.00 25.02 ? 176 ALA A CB  1 
ATOM   1147 N N   . THR A 1 149 ? 128.124 149.427 189.391 1.00 24.55 ? 177 THR A N   1 
ATOM   1148 C CA  . THR A 1 149 ? 128.078 150.064 190.700 1.00 24.55 ? 177 THR A CA  1 
ATOM   1149 C C   . THR A 1 149 ? 129.460 150.286 191.299 1.00 24.55 ? 177 THR A C   1 
ATOM   1150 O O   . THR A 1 149 ? 129.559 150.862 192.388 1.00 24.55 ? 177 THR A O   1 
ATOM   1151 C CB  . THR A 1 149 ? 127.234 149.230 191.667 1.00 24.55 ? 177 THR A CB  1 
ATOM   1152 O OG1 . THR A 1 149 ? 127.870 147.966 191.891 1.00 24.55 ? 177 THR A OG1 1 
ATOM   1153 C CG2 . THR A 1 149 ? 125.844 148.999 191.096 1.00 24.55 ? 177 THR A CG2 1 
ATOM   1154 N N   . HIS A 1 150 ? 130.517 149.841 190.625 1.00 25.64 ? 178 HIS A N   1 
ATOM   1155 C CA  . HIS A 1 150 ? 131.868 150.044 191.130 1.00 25.64 ? 178 HIS A CA  1 
ATOM   1156 C C   . HIS A 1 150 ? 132.227 151.524 191.118 1.00 25.64 ? 178 HIS A C   1 
ATOM   1157 O O   . HIS A 1 150 ? 131.879 152.258 190.190 1.00 25.64 ? 178 HIS A O   1 
ATOM   1158 C CB  . HIS A 1 150 ? 132.872 149.253 190.293 1.00 25.64 ? 178 HIS A CB  1 
ATOM   1159 C CG  . HIS A 1 150 ? 133.074 147.846 190.763 1.00 25.64 ? 178 HIS A CG  1 
ATOM   1160 N ND1 . HIS A 1 150 ? 134.242 147.149 190.543 1.00 25.64 ? 178 HIS A ND1 1 
ATOM   1161 C CD2 . HIS A 1 150 ? 132.257 147.007 191.442 1.00 25.64 ? 178 HIS A CD2 1 
ATOM   1162 C CE1 . HIS A 1 150 ? 134.136 145.940 191.066 1.00 25.64 ? 178 HIS A CE1 1 
ATOM   1163 N NE2 . HIS A 1 150 ? 132.941 145.829 191.618 1.00 25.64 ? 178 HIS A NE2 1 
ATOM   1164 N N   . GLN A 1 151 ? 132.926 151.961 192.168 1.00 22.65 ? 179 GLN A N   1 
ATOM   1165 C CA  . GLN A 1 151 ? 133.330 153.359 192.257 1.00 22.65 ? 179 GLN A CA  1 
ATOM   1166 C C   . GLN A 1 151 ? 134.306 153.727 191.145 1.00 22.65 ? 179 GLN A C   1 
ATOM   1167 O O   . GLN A 1 151 ? 134.231 154.832 190.595 1.00 22.65 ? 179 GLN A O   1 
ATOM   1168 C CB  . GLN A 1 151 ? 133.949 153.637 193.627 1.00 22.65 ? 179 GLN A CB  1 
ATOM   1169 C CG  . GLN A 1 151 ? 134.528 155.033 193.792 1.00 22.65 ? 179 GLN A CG  1 
ATOM   1170 C CD  . GLN A 1 151 ? 133.517 156.123 193.481 1.00 22.65 ? 179 GLN A CD  1 
ATOM   1171 O OE1 . GLN A 1 151 ? 133.630 156.825 192.477 1.00 22.65 ? 179 GLN A OE1 1 
ATOM   1172 N NE2 . GLN A 1 151 ? 132.521 156.268 194.348 1.00 22.65 ? 179 GLN A NE2 1 
ATOM   1173 N N   . GLU A 1 152 ? 135.221 152.816 190.801 1.00 26.75 ? 180 GLU A N   1 
ATOM   1174 C CA  . GLU A 1 152 ? 136.156 153.075 189.711 1.00 26.75 ? 180 GLU A CA  1 
ATOM   1175 C C   . GLU A 1 152 ? 135.423 153.248 188.387 1.00 26.75 ? 180 GLU A C   1 
ATOM   1176 O O   . GLU A 1 152 ? 135.781 154.112 187.578 1.00 26.75 ? 180 GLU A O   1 
ATOM   1177 C CB  . GLU A 1 152 ? 137.176 151.942 189.614 1.00 26.75 ? 180 GLU A CB  1 
ATOM   1178 C CG  . GLU A 1 152 ? 137.565 151.340 190.953 1.00 26.75 ? 180 GLU A CG  1 
ATOM   1179 C CD  . GLU A 1 152 ? 138.837 150.520 190.876 1.00 26.75 ? 180 GLU A CD  1 
ATOM   1180 O OE1 . GLU A 1 152 ? 139.051 149.849 189.846 1.00 26.75 ? 180 GLU A OE1 1 
ATOM   1181 O OE2 . GLU A 1 152 ? 139.623 150.546 191.847 1.00 26.75 ? 180 GLU A OE2 1 
ATOM   1182 N N   . ALA A 1 153 ? 134.399 152.426 188.145 1.00 23.29 ? 181 ALA A N   1 
ATOM   1183 C CA  . ALA A 1 153 ? 133.607 152.571 186.928 1.00 23.29 ? 181 ALA A CA  1 
ATOM   1184 C C   . ALA A 1 153 ? 132.903 153.920 186.888 1.00 23.29 ? 181 ALA A C   1 
ATOM   1185 O O   . ALA A 1 153 ? 132.866 154.579 185.842 1.00 23.29 ? 181 ALA A O   1 
ATOM   1186 C CB  . ALA A 1 153 ? 132.591 151.434 186.825 1.00 23.29 ? 181 ALA A CB  1 
ATOM   1187 N N   . ILE A 1 154 ? 132.340 154.349 188.020 1.00 22.25 ? 182 ILE A N   1 
ATOM   1188 C CA  . ILE A 1 154 ? 131.674 155.647 188.079 1.00 22.25 ? 182 ILE A CA  1 
ATOM   1189 C C   . ILE A 1 154 ? 132.667 156.766 187.795 1.00 22.25 ? 182 ILE A C   1 
ATOM   1190 O O   . ILE A 1 154 ? 132.369 157.707 187.049 1.00 22.25 ? 182 ILE A O   1 
ATOM   1191 C CB  . ILE A 1 154 ? 130.986 155.830 189.444 1.00 22.25 ? 182 ILE A CB  1 
ATOM   1192 C CG1 . ILE A 1 154 ? 129.853 154.816 189.609 1.00 22.25 ? 182 ILE A CG1 1 
ATOM   1193 C CG2 . ILE A 1 154 ? 130.456 157.247 189.592 1.00 22.25 ? 182 ILE A CG2 1 
ATOM   1194 C CD1 . ILE A 1 154 ? 128.745 154.973 188.593 1.00 22.25 ? 182 ILE A CD1 1 
ATOM   1195 N N   . ASN A 1 155 ? 133.862 156.680 188.383 1.00 21.56 ? 183 ASN A N   1 
ATOM   1196 C CA  . ASN A 1 155 ? 134.876 157.703 188.153 1.00 21.56 ? 183 ASN A CA  1 
ATOM   1197 C C   . ASN A 1 155 ? 135.302 157.746 186.691 1.00 21.56 ? 183 ASN A C   1 
ATOM   1198 O O   . ASN A 1 155 ? 135.449 158.828 186.112 1.00 21.56 ? 183 ASN A O   1 
ATOM   1199 C CB  . ASN A 1 155 ? 136.083 157.453 189.055 1.00 21.56 ? 183 ASN A CB  1 
ATOM   1200 C CG  . ASN A 1 155 ? 135.775 157.696 190.517 1.00 21.56 ? 183 ASN A CG  1 
ATOM   1201 O OD1 . ASN A 1 155 ? 135.098 158.662 190.867 1.00 21.56 ? 183 ASN A OD1 1 
ATOM   1202 N ND2 . ASN A 1 155 ? 136.265 156.815 191.380 1.00 21.56 ? 183 ASN A ND2 1 
ATOM   1203 N N   . CYS A 1 156 ? 135.501 156.578 186.076 1.00 23.27 ? 184 CYS A N   1 
ATOM   1204 C CA  . CYS A 1 156 ? 135.943 156.547 184.686 1.00 23.27 ? 184 CYS A CA  1 
ATOM   1205 C C   . CYS A 1 156 ? 134.847 157.037 183.747 1.00 23.27 ? 184 CYS A C   1 
ATOM   1206 O O   . CYS A 1 156 ? 135.137 157.642 182.708 1.00 23.27 ? 184 CYS A O   1 
ATOM   1207 C CB  . CYS A 1 156 ? 136.394 155.136 184.308 1.00 23.27 ? 184 CYS A CB  1 
ATOM   1208 S SG  . CYS A 1 156 ? 136.991 154.960 182.607 1.00 23.27 ? 184 CYS A SG  1 
ATOM   1209 N N   . TYR A 1 157 ? 133.581 156.783 184.090 1.00 23.44 ? 185 TYR A N   1 
ATOM   1210 C CA  . TYR A 1 157 ? 132.486 157.295 183.271 1.00 23.44 ? 185 TYR A CA  1 
ATOM   1211 C C   . TYR A 1 157 ? 132.491 158.818 183.237 1.00 23.44 ? 185 TYR A C   1 
ATOM   1212 O O   . TYR A 1 157 ? 132.299 159.423 182.176 1.00 23.44 ? 185 TYR A O   1 
ATOM   1213 C CB  . TYR A 1 157 ? 131.145 156.776 183.791 1.00 23.44 ? 185 TYR A CB  1 
ATOM   1214 C CG  . TYR A 1 157 ? 130.956 155.283 183.645 1.00 23.44 ? 185 TYR A CG  1 
ATOM   1215 C CD1 . TYR A 1 157 ? 130.003 154.609 184.397 1.00 23.44 ? 185 TYR A CD1 1 
ATOM   1216 C CD2 . TYR A 1 157 ? 131.726 154.547 182.753 1.00 23.44 ? 185 TYR A CD2 1 
ATOM   1217 C CE1 . TYR A 1 157 ? 129.823 153.246 184.269 1.00 23.44 ? 185 TYR A CE1 1 
ATOM   1218 C CE2 . TYR A 1 157 ? 131.554 153.183 182.618 1.00 23.44 ? 185 TYR A CE2 1 
ATOM   1219 C CZ  . TYR A 1 157 ? 130.600 152.537 183.379 1.00 23.44 ? 185 TYR A CZ  1 
ATOM   1220 O OH  . TYR A 1 157 ? 130.422 151.179 183.249 1.00 23.44 ? 185 TYR A OH  1 
ATOM   1221 N N   . ALA A 1 158 ? 132.710 159.453 184.384 1.00 21.01 ? 186 ALA A N   1 
ATOM   1222 C CA  . ALA A 1 158 ? 132.829 160.909 184.456 1.00 21.01 ? 186 ALA A CA  1 
ATOM   1223 C C   . ALA A 1 158 ? 134.283 161.351 184.326 1.00 21.01 ? 186 ALA A C   1 
ATOM   1224 O O   . ALA A 1 158 ? 134.807 162.102 185.147 1.00 21.01 ? 186 ALA A O   1 
ATOM   1225 C CB  . ALA A 1 158 ? 132.213 161.420 185.752 1.00 21.01 ? 186 ALA A CB  1 
ATOM   1226 N N   . GLU A 1 159 ? 134.945 160.874 183.276 1.00 21.67 ? 187 GLU A N   1 
ATOM   1227 C CA  . GLU A 1 159 ? 136.339 161.209 183.030 1.00 21.67 ? 187 GLU A CA  1 
ATOM   1228 C C   . GLU A 1 159 ? 136.606 161.064 181.539 1.00 21.67 ? 187 GLU A C   1 
ATOM   1229 O O   . GLU A 1 159 ? 136.023 160.203 180.875 1.00 21.67 ? 187 GLU A O   1 
ATOM   1230 C CB  . GLU A 1 159 ? 137.279 160.317 183.848 1.00 21.67 ? 187 GLU A CB  1 
ATOM   1231 C CG  . GLU A 1 159 ? 138.615 160.956 184.174 1.00 21.67 ? 187 GLU A CG  1 
ATOM   1232 C CD  . GLU A 1 159 ? 139.618 160.808 183.055 1.00 21.67 ? 187 GLU A CD  1 
ATOM   1233 O OE1 . GLU A 1 159 ? 139.519 159.818 182.302 1.00 21.67 ? 187 GLU A OE1 1 
ATOM   1234 O OE2 . GLU A 1 159 ? 140.501 161.679 182.928 1.00 21.67 ? 187 GLU A OE2 1 
ATOM   1235 N N   . GLU A 1 160 ? 137.493 161.915 181.022 1.00 21.49 ? 188 GLU A N   1 
ATOM   1236 C CA  . GLU A 1 160 ? 137.699 162.051 179.585 1.00 21.49 ? 188 GLU A CA  1 
ATOM   1237 C C   . GLU A 1 160 ? 139.023 161.457 179.112 1.00 21.49 ? 188 GLU A C   1 
ATOM   1238 O O   . GLU A 1 160 ? 139.480 161.780 178.011 1.00 21.49 ? 188 GLU A O   1 
ATOM   1239 C CB  . GLU A 1 160 ? 137.608 163.523 179.175 1.00 21.49 ? 188 GLU A CB  1 
ATOM   1240 C CG  . GLU A 1 160 ? 138.649 164.445 179.815 1.00 21.49 ? 188 GLU A CG  1 
ATOM   1241 C CD  . GLU A 1 160 ? 138.369 164.759 181.277 1.00 21.49 ? 188 GLU A CD  1 
ATOM   1242 O OE1 . GLU A 1 160 ? 139.168 165.499 181.889 1.00 21.49 ? 188 GLU A OE1 1 
ATOM   1243 O OE2 . GLU A 1 160 ? 137.350 164.275 181.813 1.00 21.49 ? 188 GLU A OE2 1 
ATOM   1244 N N   . THR A 1 161 ? 139.649 160.607 179.909 1.00 19.92 ? 189 THR A N   1 
ATOM   1245 C CA  . THR A 1 161 ? 140.924 160.034 179.489 1.00 19.92 ? 189 THR A CA  1 
ATOM   1246 C C   . THR A 1 161 ? 140.970 158.516 179.585 1.00 19.92 ? 189 THR A C   1 
ATOM   1247 O O   . THR A 1 161 ? 141.591 157.877 178.732 1.00 19.92 ? 189 THR A O   1 
ATOM   1248 C CB  . THR A 1 161 ? 142.066 160.642 180.321 1.00 19.92 ? 189 THR A CB  1 
ATOM   1249 O OG1 . THR A 1 161 ? 141.970 162.071 180.291 1.00 19.92 ? 189 THR A OG1 1 
ATOM   1250 C CG2 . THR A 1 161 ? 143.420 160.224 179.766 1.00 19.92 ? 189 THR A CG2 1 
ATOM   1251 N N   . CYS A 1 162 ? 140.327 157.924 180.594 1.00 21.01 ? 190 CYS A N   1 
ATOM   1252 C CA  . CYS A 1 162 ? 140.489 156.494 180.846 1.00 21.01 ? 190 CYS A CA  1 
ATOM   1253 C C   . CYS A 1 162 ? 139.984 155.660 179.674 1.00 21.01 ? 190 CYS A C   1 
ATOM   1254 O O   . CYS A 1 162 ? 140.764 154.978 179.000 1.00 21.01 ? 190 CYS A O   1 
ATOM   1255 C CB  . CYS A 1 162 ? 139.769 156.101 182.139 1.00 21.01 ? 190 CYS A CB  1 
ATOM   1256 S SG  . CYS A 1 162 ? 138.054 156.657 182.255 1.00 21.01 ? 190 CYS A SG  1 
ATOM   1257 N N   . CYS A 1 163 ? 138.679 155.715 179.409 1.00 20.46 ? 191 CYS A N   1 
ATOM   1258 C CA  . CYS A 1 163 ? 138.047 154.913 178.361 1.00 20.46 ? 191 CYS A CA  1 
ATOM   1259 C C   . CYS A 1 163 ? 138.419 153.436 178.504 1.00 20.46 ? 191 CYS A C   1 
ATOM   1260 O O   . CYS A 1 163 ? 138.847 152.775 177.556 1.00 20.46 ? 191 CYS A O   1 
ATOM   1261 C CB  . CYS A 1 163 ? 138.403 155.448 176.972 1.00 20.46 ? 191 CYS A CB  1 
ATOM   1262 S SG  . CYS A 1 163 ? 137.593 154.624 175.567 1.00 20.46 ? 191 CYS A SG  1 
ATOM   1263 N N   . ASP A 1 164 ? 138.275 152.924 179.723 1.00 21.62 ? 192 ASP A N   1 
ATOM   1264 C CA  . ASP A 1 164 ? 138.433 151.503 179.998 1.00 21.62 ? 192 ASP A CA  1 
ATOM   1265 C C   . ASP A 1 164 ? 137.065 150.844 179.896 1.00 21.62 ? 192 ASP A C   1 
ATOM   1266 O O   . ASP A 1 164 ? 136.129 151.236 180.600 1.00 21.62 ? 192 ASP A O   1 
ATOM   1267 C CB  . ASP A 1 164 ? 139.048 151.265 181.377 1.00 21.62 ? 192 ASP A CB  1 
ATOM   1268 C CG  . ASP A 1 164 ? 140.547 151.495 181.395 1.00 21.62 ? 192 ASP A CG  1 
ATOM   1269 O OD1 . ASP A 1 164 ? 141.190 151.309 180.341 1.00 21.62 ? 192 ASP A OD1 1 
ATOM   1270 O OD2 . ASP A 1 164 ? 141.083 151.854 182.465 1.00 21.62 ? 192 ASP A OD2 1 
ATOM   1271 N N   . PHE A 1 165 ? 137.011 149.839 179.017 1.00 17.64 ? 193 PHE A N   1 
ATOM   1272 C CA  . PHE A 1 165 ? 135.729 149.146 178.782 1.00 17.64 ? 193 PHE A CA  1 
ATOM   1273 C C   . PHE A 1 165 ? 135.364 148.416 180.050 1.00 17.64 ? 193 PHE A C   1 
ATOM   1274 O O   . PHE A 1 165 ? 136.050 147.451 180.393 1.00 17.64 ? 193 PHE A O   1 
ATOM   1275 C CB  . PHE A 1 165 ? 135.815 148.162 177.620 1.00 17.64 ? 193 PHE A CB  1 
ATOM   1276 C CG  . PHE A 1 165 ? 134.498 147.856 176.951 1.00 17.64 ? 193 PHE A CG  1 
ATOM   1277 C CD1 . PHE A 1 165 ? 133.297 148.194 177.550 1.00 17.64 ? 193 PHE A CD1 1 
ATOM   1278 C CD2 . PHE A 1 165 ? 134.461 147.229 175.718 1.00 17.64 ? 193 PHE A CD2 1 
ATOM   1279 C CE1 . PHE A 1 165 ? 132.091 147.909 176.934 1.00 17.64 ? 193 PHE A CE1 1 
ATOM   1280 C CE2 . PHE A 1 165 ? 133.254 146.949 175.101 1.00 17.64 ? 193 PHE A CE2 1 
ATOM   1281 C CZ  . PHE A 1 165 ? 132.072 147.286 175.711 1.00 17.64 ? 193 PHE A CZ  1 
ATOM   1282 N N   . PHE A 1 166 ? 134.377 148.926 180.760 1.00 23.06 ? 194 PHE A N   1 
ATOM   1283 C CA  . PHE A 1 166 ? 133.858 148.220 181.922 1.00 23.06 ? 194 PHE A CA  1 
ATOM   1284 C C   . PHE A 1 166 ? 132.506 147.611 181.585 1.00 23.06 ? 194 PHE A C   1 
ATOM   1285 O O   . PHE A 1 166 ? 131.643 148.270 180.999 1.00 23.06 ? 194 PHE A O   1 
ATOM   1286 C CB  . PHE A 1 166 ? 133.734 149.152 183.128 1.00 23.06 ? 194 PHE A CB  1 
ATOM   1287 C CG  . PHE A 1 166 ? 134.992 149.255 183.943 1.00 23.06 ? 194 PHE A CG  1 
ATOM   1288 C CD1 . PHE A 1 166 ? 134.934 149.329 185.324 1.00 23.06 ? 194 PHE A CD1 1 
ATOM   1289 C CD2 . PHE A 1 166 ? 136.233 149.276 183.328 1.00 23.06 ? 194 PHE A CD2 1 
ATOM   1290 C CE1 . PHE A 1 166 ? 136.089 149.423 186.076 1.00 23.06 ? 194 PHE A CE1 1 
ATOM   1291 C CE2 . PHE A 1 166 ? 137.392 149.370 184.075 1.00 23.06 ? 194 PHE A CE2 1 
ATOM   1292 C CZ  . PHE A 1 166 ? 137.319 149.444 185.451 1.00 23.06 ? 194 PHE A CZ  1 
ATOM   1293 N N   . THR A 1 167 ? 132.327 146.349 181.964 1.00 19.82 ? 195 THR A N   1 
ATOM   1294 C CA  . THR A 1 167 ? 131.187 145.555 181.537 1.00 19.82 ? 195 THR A CA  1 
ATOM   1295 C C   . THR A 1 167 ? 130.270 145.252 182.713 1.00 19.82 ? 195 THR A C   1 
ATOM   1296 O O   . THR A 1 167 ? 130.724 144.886 183.801 1.00 19.82 ? 195 THR A O   1 
ATOM   1297 C CB  . THR A 1 167 ? 131.643 144.237 180.901 1.00 19.82 ? 195 THR A CB  1 
ATOM   1298 O OG1 . THR A 1 167 ? 132.365 143.465 181.868 1.00 19.82 ? 195 THR A OG1 1 
ATOM   1299 C CG2 . THR A 1 167 ? 132.546 144.508 179.711 1.00 19.82 ? 195 THR A CG2 1 
ATOM   1300 N N   . ASN A 1 168 ? 128.971 145.407 182.479 1.00 21.77 ? 196 ASN A N   1 
ATOM   1301 C CA  . ASN A 1 168 ? 127.959 144.952 183.418 1.00 21.77 ? 196 ASN A CA  1 
ATOM   1302 C C   . ASN A 1 168 ? 127.715 143.466 183.197 1.00 21.77 ? 196 ASN A C   1 
ATOM   1303 O O   . ASN A 1 168 ? 127.753 142.983 182.062 1.00 21.77 ? 196 ASN A O   1 
ATOM   1304 C CB  . ASN A 1 168 ? 126.660 145.739 183.239 1.00 21.77 ? 196 ASN A CB  1 
ATOM   1305 C CG  . ASN A 1 168 ? 125.706 145.563 184.404 1.00 21.77 ? 196 ASN A CG  1 
ATOM   1306 O OD1 . ASN A 1 168 ? 125.968 144.790 185.324 1.00 21.77 ? 196 ASN A OD1 1 
ATOM   1307 N ND2 . ASN A 1 168 ? 124.593 146.285 184.370 1.00 21.77 ? 196 ASN A ND2 1 
ATOM   1308 N N   . GLN A 1 169 ? 127.474 142.741 184.294 1.00 18.67 ? 197 GLN A N   1 
ATOM   1309 C CA  . GLN A 1 169 ? 127.369 141.286 184.218 1.00 18.67 ? 197 GLN A CA  1 
ATOM   1310 C C   . GLN A 1 169 ? 126.275 140.858 183.247 1.00 18.67 ? 197 GLN A C   1 
ATOM   1311 O O   . GLN A 1 169 ? 126.502 140.019 182.366 1.00 18.67 ? 197 GLN A O   1 
ATOM   1312 C CB  . GLN A 1 169 ? 127.111 140.710 185.611 1.00 18.67 ? 197 GLN A CB  1 
ATOM   1313 C CG  . GLN A 1 169 ? 127.519 139.255 185.770 1.00 18.67 ? 197 GLN A CG  1 
ATOM   1314 C CD  . GLN A 1 169 ? 127.627 138.835 187.223 1.00 18.67 ? 197 GLN A CD  1 
ATOM   1315 O OE1 . GLN A 1 169 ? 127.224 139.569 188.124 1.00 18.67 ? 197 GLN A OE1 1 
ATOM   1316 N NE2 . GLN A 1 169 ? 128.177 137.649 187.457 1.00 18.67 ? 197 GLN A NE2 1 
ATOM   1317 N N   . ALA A 1 170 ? 125.082 141.440 183.385 1.00 19.61 ? 198 ALA A N   1 
ATOM   1318 C CA  . ALA A 1 170 ? 123.985 141.093 182.488 1.00 19.61 ? 198 ALA A CA  1 
ATOM   1319 C C   . ALA A 1 170 ? 124.320 141.453 181.047 1.00 19.61 ? 198 ALA A C   1 
ATOM   1320 O O   . ALA A 1 170 ? 124.068 140.665 180.128 1.00 19.61 ? 198 ALA A O   1 
ATOM   1321 C CB  . ALA A 1 170 ? 122.701 141.791 182.933 1.00 19.61 ? 198 ALA A CB  1 
ATOM   1322 N N   . TYR A 1 171 ? 124.898 142.637 180.831 1.00 20.38 ? 199 TYR A N   1 
ATOM   1323 C CA  . TYR A 1 171 ? 125.265 143.035 179.477 1.00 20.38 ? 199 TYR A CA  1 
ATOM   1324 C C   . TYR A 1 171 ? 126.347 142.132 178.903 1.00 20.38 ? 199 TYR A C   1 
ATOM   1325 O O   . TYR A 1 171 ? 126.289 141.764 177.726 1.00 20.38 ? 199 TYR A O   1 
ATOM   1326 C CB  . TYR A 1 171 ? 125.727 144.489 179.448 1.00 20.38 ? 199 TYR A CB  1 
ATOM   1327 C CG  . TYR A 1 171 ? 126.114 144.941 178.060 1.00 20.38 ? 199 TYR A CG  1 
ATOM   1328 C CD1 . TYR A 1 171 ? 125.167 145.023 177.050 1.00 20.38 ? 199 TYR A CD1 1 
ATOM   1329 C CD2 . TYR A 1 171 ? 127.429 145.262 177.754 1.00 20.38 ? 199 TYR A CD2 1 
ATOM   1330 C CE1 . TYR A 1 171 ? 125.515 145.424 175.780 1.00 20.38 ? 199 TYR A CE1 1 
ATOM   1331 C CE2 . TYR A 1 171 ? 127.786 145.665 176.485 1.00 20.38 ? 199 TYR A CE2 1 
ATOM   1332 C CZ  . TYR A 1 171 ? 126.825 145.744 175.502 1.00 20.38 ? 199 TYR A CZ  1 
ATOM   1333 O OH  . TYR A 1 171 ? 127.172 146.145 174.234 1.00 20.38 ? 199 TYR A OH  1 
ATOM   1334 N N   . ALA A 1 172 ? 127.351 141.779 179.708 1.00 17.96 ? 200 ALA A N   1 
ATOM   1335 C CA  . ALA A 1 172 ? 128.408 140.901 179.218 1.00 17.96 ? 200 ALA A CA  1 
ATOM   1336 C C   . ALA A 1 172 ? 127.845 139.547 178.812 1.00 17.96 ? 200 ALA A C   1 
ATOM   1337 O O   . ALA A 1 172 ? 128.159 139.025 177.734 1.00 17.96 ? 200 ALA A O   1 
ATOM   1338 C CB  . ALA A 1 172 ? 129.493 140.738 180.282 1.00 17.96 ? 200 ALA A CB  1 
ATOM   1339 N N   . ILE A 1 173 ? 126.986 138.973 179.658 1.00 15.84 ? 201 ILE A N   1 
ATOM   1340 C CA  . ILE A 1 173 ? 126.396 137.673 179.347 1.00 15.84 ? 201 ILE A CA  1 
ATOM   1341 C C   . ILE A 1 173 ? 125.549 137.763 178.084 1.00 15.84 ? 201 ILE A C   1 
ATOM   1342 O O   . ILE A 1 173 ? 125.648 136.915 177.188 1.00 15.84 ? 201 ILE A O   1 
ATOM   1343 C CB  . ILE A 1 173 ? 125.577 137.156 180.544 1.00 15.84 ? 201 ILE A CB  1 
ATOM   1344 C CG1 . ILE A 1 173 ? 126.500 136.824 181.718 1.00 15.84 ? 201 ILE A CG1 1 
ATOM   1345 C CG2 . ILE A 1 173 ? 124.755 135.942 180.148 1.00 15.84 ? 201 ILE A CG2 1 
ATOM   1346 C CD1 . ILE A 1 173 ? 127.724 136.020 181.328 1.00 15.84 ? 201 ILE A CD1 1 
ATOM   1347 N N   . ALA A 1 174 ? 124.715 138.801 177.985 1.00 14.46 ? 202 ALA A N   1 
ATOM   1348 C CA  . ALA A 1 174 ? 123.840 138.940 176.826 1.00 14.46 ? 202 ALA A CA  1 
ATOM   1349 C C   . ALA A 1 174 ? 124.647 139.100 175.544 1.00 14.46 ? 202 ALA A C   1 
ATOM   1350 O O   . ALA A 1 174 ? 124.363 138.447 174.534 1.00 14.46 ? 202 ALA A O   1 
ATOM   1351 C CB  . ALA A 1 174 ? 122.895 140.125 177.022 1.00 14.46 ? 202 ALA A CB  1 
ATOM   1352 N N   . SER A 1 175 ? 125.658 139.969 175.592 1.00 14.13 ? 203 SER A N   1 
ATOM   1353 C CA  . SER A 1 175 ? 126.495 140.213 174.389 1.00 14.13 ? 203 SER A CA  1 
ATOM   1354 C C   . SER A 1 175 ? 127.192 138.911 173.980 1.00 14.13 ? 203 SER A C   1 
ATOM   1355 O O   . SER A 1 175 ? 127.173 138.595 172.781 1.00 14.13 ? 203 SER A O   1 
ATOM   1356 C CB  . SER A 1 175 ? 127.478 141.326 174.627 1.00 14.13 ? 203 SER A CB  1 
ATOM   1357 O OG  . SER A 1 175 ? 127.870 141.916 173.398 1.00 14.13 ? 203 SER A OG  1 
ATOM   1358 N N   . SER A 1 176 ? 127.760 138.176 174.941 1.00 12.91 ? 204 SER A N   1 
ATOM   1359 C CA  . SER A 1 176 ? 128.487 136.956 174.612 1.00 12.91 ? 204 SER A CA  1 
ATOM   1360 C C   . SER A 1 176 ? 127.556 135.891 174.042 1.00 12.91 ? 204 SER A C   1 
ATOM   1361 O O   . SER A 1 176 ? 127.940 135.136 173.141 1.00 12.91 ? 204 SER A O   1 
ATOM   1362 C CB  . SER A 1 176 ? 129.223 136.436 175.845 1.00 12.91 ? 204 SER A CB  1 
ATOM   1363 O OG  . SER A 1 176 ? 128.306 136.062 176.856 1.00 12.91 ? 204 SER A OG  1 
ATOM   1364 N N   . ILE A 1 177 ? 126.324 135.810 174.552 1.00 12.47 ? 205 ILE A N   1 
ATOM   1365 C CA  . ILE A 1 177 ? 125.435 134.757 174.067 1.00 12.47 ? 205 ILE A CA  1 
ATOM   1366 C C   . ILE A 1 177 ? 124.769 135.148 172.753 1.00 12.47 ? 205 ILE A C   1 
ATOM   1367 O O   . ILE A 1 177 ? 124.300 134.277 172.013 1.00 12.47 ? 205 ILE A O   1 
ATOM   1368 C CB  . ILE A 1 177 ? 124.386 134.376 175.129 1.00 12.47 ? 205 ILE A CB  1 
ATOM   1369 C CG1 . ILE A 1 177 ? 123.415 135.532 175.378 1.00 12.47 ? 205 ILE A CG1 1 
ATOM   1370 C CG2 . ILE A 1 177 ? 125.063 133.915 176.412 1.00 12.47 ? 205 ILE A CG2 1 
ATOM   1371 C CD1 . ILE A 1 177 ? 122.235 135.160 176.247 1.00 12.47 ? 205 ILE A CD1 1 
ATOM   1372 N N   . VAL A 1 178 ? 124.701 136.445 172.430 1.00 9.85  ? 206 VAL A N   1 
ATOM   1373 C CA  . VAL A 1 178 ? 124.057 136.837 171.177 1.00 9.85  ? 206 VAL A CA  1 
ATOM   1374 C C   . VAL A 1 178 ? 125.035 137.256 170.089 1.00 9.85  ? 206 VAL A C   1 
ATOM   1375 O O   . VAL A 1 178 ? 124.596 137.597 168.980 1.00 9.85  ? 206 VAL A O   1 
ATOM   1376 C CB  . VAL A 1 178 ? 123.048 137.986 171.375 1.00 9.85  ? 206 VAL A CB  1 
ATOM   1377 C CG1 . VAL A 1 178 ? 122.090 137.668 172.514 1.00 9.85  ? 206 VAL A CG1 1 
ATOM   1378 C CG2 . VAL A 1 178 ? 123.771 139.304 171.603 1.00 9.85  ? 206 VAL A CG2 1 
ATOM   1379 N N   . SER A 1 179 ? 126.338 137.242 170.355 1.00 6.47  ? 207 SER A N   1 
ATOM   1380 C CA  . SER A 1 179 ? 127.304 137.663 169.350 1.00 6.47  ? 207 SER A CA  1 
ATOM   1381 C C   . SER A 1 179 ? 128.340 136.610 168.996 1.00 6.47  ? 207 SER A C   1 
ATOM   1382 O O   . SER A 1 179 ? 128.844 136.625 167.873 1.00 6.47  ? 207 SER A O   1 
ATOM   1383 C CB  . SER A 1 179 ? 128.037 138.932 169.811 1.00 6.47  ? 207 SER A CB  1 
ATOM   1384 O OG  . SER A 1 179 ? 127.141 140.024 169.912 1.00 6.47  ? 207 SER A OG  1 
ATOM   1385 N N   . PHE A 1 180 ? 128.677 135.707 169.911 1.00 11.15 ? 208 PHE A N   1 
ATOM   1386 C CA  . PHE A 1 180 ? 129.734 134.743 169.648 1.00 11.15 ? 208 PHE A CA  1 
ATOM   1387 C C   . PHE A 1 180 ? 129.421 133.338 170.141 1.00 11.15 ? 208 PHE A C   1 
ATOM   1388 O O   . PHE A 1 180 ? 130.268 132.454 169.997 1.00 11.15 ? 208 PHE A O   1 
ATOM   1389 C CB  . PHE A 1 180 ? 131.052 135.234 170.273 1.00 11.15 ? 208 PHE A CB  1 
ATOM   1390 C CG  . PHE A 1 180 ? 132.286 134.665 169.632 1.00 11.15 ? 208 PHE A CG  1 
ATOM   1391 C CD1 . PHE A 1 180 ? 132.868 133.506 170.111 1.00 11.15 ? 208 PHE A CD1 1 
ATOM   1392 C CD2 . PHE A 1 180 ? 132.859 135.289 168.544 1.00 11.15 ? 208 PHE A CD2 1 
ATOM   1393 C CE1 . PHE A 1 180 ? 133.994 132.985 169.523 1.00 11.15 ? 208 PHE A CE1 1 
ATOM   1394 C CE2 . PHE A 1 180 ? 133.990 134.773 167.953 1.00 11.15 ? 208 PHE A CE2 1 
ATOM   1395 C CZ  . PHE A 1 180 ? 134.556 133.618 168.443 1.00 11.15 ? 208 PHE A CZ  1 
ATOM   1396 N N   . TYR A 1 181 ? 128.240 133.086 170.689 1.00 7.53  ? 209 TYR A N   1 
ATOM   1397 C CA  . TYR A 1 181 ? 127.912 131.742 171.144 1.00 7.53  ? 209 TYR A CA  1 
ATOM   1398 C C   . TYR A 1 181 ? 126.809 131.078 170.338 1.00 7.53  ? 209 TYR A C   1 
ATOM   1399 O O   . TYR A 1 181 ? 126.922 129.895 170.015 1.00 7.53  ? 209 TYR A O   1 
ATOM   1400 C CB  . TYR A 1 181 ? 127.534 131.765 172.627 1.00 7.53  ? 209 TYR A CB  1 
ATOM   1401 C CG  . TYR A 1 181 ? 128.749 131.825 173.523 1.00 7.53  ? 209 TYR A CG  1 
ATOM   1402 C CD1 . TYR A 1 181 ? 129.932 131.196 173.157 1.00 7.53  ? 209 TYR A CD1 1 
ATOM   1403 C CD2 . TYR A 1 181 ? 128.718 132.511 174.728 1.00 7.53  ? 209 TYR A CD2 1 
ATOM   1404 C CE1 . TYR A 1 181 ? 131.049 131.246 173.964 1.00 7.53  ? 209 TYR A CE1 1 
ATOM   1405 C CE2 . TYR A 1 181 ? 129.832 132.566 175.544 1.00 7.53  ? 209 TYR A CE2 1 
ATOM   1406 C CZ  . TYR A 1 181 ? 130.994 131.931 175.156 1.00 7.53  ? 209 TYR A CZ  1 
ATOM   1407 O OH  . TYR A 1 181 ? 132.107 131.982 175.963 1.00 7.53  ? 209 TYR A OH  1 
ATOM   1408 N N   . VAL A 1 182 ? 125.751 131.801 169.991 1.00 6.57  ? 210 VAL A N   1 
ATOM   1409 C CA  . VAL A 1 182 ? 124.693 131.235 169.159 1.00 6.57  ? 210 VAL A CA  1 
ATOM   1410 C C   . VAL A 1 182 ? 125.175 131.118 167.714 1.00 6.57  ? 210 VAL A C   1 
ATOM   1411 O O   . VAL A 1 182 ? 125.121 130.014 167.147 1.00 6.57  ? 210 VAL A O   1 
ATOM   1412 C CB  . VAL A 1 182 ? 123.395 132.053 169.270 1.00 6.57  ? 210 VAL A CB  1 
ATOM   1413 C CG1 . VAL A 1 182 ? 122.430 131.664 168.168 1.00 6.57  ? 210 VAL A CG1 1 
ATOM   1414 C CG2 . VAL A 1 182 ? 122.759 131.841 170.630 1.00 6.57  ? 210 VAL A CG2 1 
ATOM   1415 N N   . PRO A 1 183 ? 125.645 132.192 167.065 1.00 4.54  ? 211 PRO A N   1 
ATOM   1416 C CA  . PRO A 1 183 ? 126.111 132.029 165.680 1.00 4.54  ? 211 PRO A CA  1 
ATOM   1417 C C   . PRO A 1 183 ? 127.295 131.094 165.546 1.00 4.54  ? 211 PRO A C   1 
ATOM   1418 O O   . PRO A 1 183 ? 127.432 130.439 164.507 1.00 4.54  ? 211 PRO A O   1 
ATOM   1419 C CB  . PRO A 1 183 ? 126.464 133.459 165.254 1.00 4.54  ? 211 PRO A CB  1 
ATOM   1420 C CG  . PRO A 1 183 ? 125.728 134.330 166.192 1.00 4.54  ? 211 PRO A CG  1 
ATOM   1421 C CD  . PRO A 1 183 ? 125.760 133.597 167.488 1.00 4.54  ? 211 PRO A CD  1 
ATOM   1422 N N   . LEU A 1 184 ? 128.147 130.988 166.567 1.00 3.97  ? 212 LEU A N   1 
ATOM   1423 C CA  . LEU A 1 184 ? 129.262 130.050 166.487 1.00 3.97  ? 212 LEU A CA  1 
ATOM   1424 C C   . LEU A 1 184 ? 128.769 128.608 166.441 1.00 3.97  ? 212 LEU A C   1 
ATOM   1425 O O   . LEU A 1 184 ? 129.196 127.820 165.587 1.00 3.97  ? 212 LEU A O   1 
ATOM   1426 C CB  . LEU A 1 184 ? 130.212 130.249 167.664 1.00 3.97  ? 212 LEU A CB  1 
ATOM   1427 C CG  . LEU A 1 184 ? 131.482 129.409 167.556 1.00 3.97  ? 212 LEU A CG  1 
ATOM   1428 C CD1 . LEU A 1 184 ? 132.124 129.616 166.202 1.00 3.97  ? 212 LEU A CD1 1 
ATOM   1429 C CD2 . LEU A 1 184 ? 132.451 129.758 168.664 1.00 3.97  ? 212 LEU A CD2 1 
ATOM   1430 N N   . VAL A 1 185 ? 127.865 128.240 167.352 1.00 3.42  ? 213 VAL A N   1 
ATOM   1431 C CA  . VAL A 1 185 ? 127.365 126.871 167.326 1.00 3.42  ? 213 VAL A CA  1 
ATOM   1432 C C   . VAL A 1 185 ? 126.574 126.624 166.049 1.00 3.42  ? 213 VAL A C   1 
ATOM   1433 O O   . VAL A 1 185 ? 126.628 125.525 165.488 1.00 3.42  ? 213 VAL A O   1 
ATOM   1434 C CB  . VAL A 1 185 ? 126.539 126.547 168.587 1.00 3.42  ? 213 VAL A CB  1 
ATOM   1435 C CG1 . VAL A 1 185 ? 125.220 127.299 168.603 1.00 3.42  ? 213 VAL A CG1 1 
ATOM   1436 C CG2 . VAL A 1 185 ? 126.304 125.050 168.689 1.00 3.42  ? 213 VAL A CG2 1 
ATOM   1437 N N   . ILE A 1 186 ? 125.856 127.633 165.549 1.00 4.27  ? 214 ILE A N   1 
ATOM   1438 C CA  . ILE A 1 186 ? 125.082 127.446 164.325 1.00 4.27  ? 214 ILE A CA  1 
ATOM   1439 C C   . ILE A 1 186 ? 126.003 127.186 163.136 1.00 4.27  ? 214 ILE A C   1 
ATOM   1440 O O   . ILE A 1 186 ? 125.768 126.266 162.343 1.00 4.27  ? 214 ILE A O   1 
ATOM   1441 C CB  . ILE A 1 186 ? 124.161 128.652 164.080 1.00 4.27  ? 214 ILE A CB  1 
ATOM   1442 C CG1 . ILE A 1 186 ? 122.878 128.502 164.897 1.00 4.27  ? 214 ILE A CG1 1 
ATOM   1443 C CG2 . ILE A 1 186 ? 123.835 128.783 162.606 1.00 4.27  ? 214 ILE A CG2 1 
ATOM   1444 C CD1 . ILE A 1 186 ? 121.987 129.721 164.869 1.00 4.27  ? 214 ILE A CD1 1 
ATOM   1445 N N   . MET A 1 187 ? 127.063 127.985 162.991 1.00 2.92  ? 215 MET A N   1 
ATOM   1446 C CA  . MET A 1 187 ? 127.973 127.778 161.868 1.00 2.92  ? 215 MET A CA  1 
ATOM   1447 C C   . MET A 1 187 ? 128.693 126.441 161.983 1.00 2.92  ? 215 MET A C   1 
ATOM   1448 O O   . MET A 1 187 ? 128.862 125.737 160.979 1.00 2.92  ? 215 MET A O   1 
ATOM   1449 C CB  . MET A 1 187 ? 128.969 128.936 161.755 1.00 2.92  ? 215 MET A CB  1 
ATOM   1450 C CG  . MET A 1 187 ? 129.931 129.079 162.916 1.00 2.92  ? 215 MET A CG  1 
ATOM   1451 S SD  . MET A 1 187 ? 131.110 130.435 162.764 1.00 2.92  ? 215 MET A SD  1 
ATOM   1452 C CE  . MET A 1 187 ? 132.199 129.805 161.498 1.00 2.92  ? 215 MET A CE  1 
ATOM   1453 N N   . VAL A 1 188 ? 129.097 126.053 163.197 1.00 3.20  ? 216 VAL A N   1 
ATOM   1454 C CA  . VAL A 1 188 ? 129.765 124.762 163.364 1.00 3.20  ? 216 VAL A CA  1 
ATOM   1455 C C   . VAL A 1 188 ? 128.822 123.620 163.003 1.00 3.20  ? 216 VAL A C   1 
ATOM   1456 O O   . VAL A 1 188 ? 129.204 122.679 162.298 1.00 3.20  ? 216 VAL A O   1 
ATOM   1457 C CB  . VAL A 1 188 ? 130.313 124.614 164.793 1.00 3.20  ? 216 VAL A CB  1 
ATOM   1458 C CG1 . VAL A 1 188 ? 130.883 123.228 164.986 1.00 3.20  ? 216 VAL A CG1 1 
ATOM   1459 C CG2 . VAL A 1 188 ? 131.394 125.641 165.040 1.00 3.20  ? 216 VAL A CG2 1 
ATOM   1460 N N   . PHE A 1 189 ? 127.573 123.691 163.466 1.00 4.34  ? 217 PHE A N   1 
ATOM   1461 C CA  . PHE A 1 189 ? 126.606 122.632 163.189 1.00 4.34  ? 217 PHE A CA  1 
ATOM   1462 C C   . PHE A 1 189 ? 126.342 122.518 161.690 1.00 4.34  ? 217 PHE A C   1 
ATOM   1463 O O   . PHE A 1 189 ? 126.368 121.419 161.120 1.00 4.34  ? 217 PHE A O   1 
ATOM   1464 C CB  . PHE A 1 189 ? 125.314 122.929 163.955 1.00 4.34  ? 217 PHE A CB  1 
ATOM   1465 C CG  . PHE A 1 189 ? 124.281 121.839 163.892 1.00 4.34  ? 217 PHE A CG  1 
ATOM   1466 C CD1 . PHE A 1 189 ? 124.584 120.582 163.399 1.00 4.34  ? 217 PHE A CD1 1 
ATOM   1467 C CD2 . PHE A 1 189 ? 122.993 122.083 164.333 1.00 4.34  ? 217 PHE A CD2 1 
ATOM   1468 C CE1 . PHE A 1 189 ? 123.624 119.590 163.351 1.00 4.34  ? 217 PHE A CE1 1 
ATOM   1469 C CE2 . PHE A 1 189 ? 122.028 121.097 164.285 1.00 4.34  ? 217 PHE A CE2 1 
ATOM   1470 C CZ  . PHE A 1 189 ? 122.344 119.849 163.792 1.00 4.34  ? 217 PHE A CZ  1 
ATOM   1471 N N   . VAL A 1 190 ? 126.104 123.654 161.029 1.00 4.21  ? 218 VAL A N   1 
ATOM   1472 C CA  . VAL A 1 190 ? 125.777 123.635 159.606 1.00 4.21  ? 218 VAL A CA  1 
ATOM   1473 C C   . VAL A 1 190 ? 126.952 123.122 158.785 1.00 4.21  ? 218 VAL A C   1 
ATOM   1474 O O   . VAL A 1 190 ? 126.777 122.317 157.861 1.00 4.21  ? 218 VAL A O   1 
ATOM   1475 C CB  . VAL A 1 190 ? 125.325 125.030 159.144 1.00 4.21  ? 218 VAL A CB  1 
ATOM   1476 C CG1 . VAL A 1 190 ? 125.252 125.085 157.640 1.00 4.21  ? 218 VAL A CG1 1 
ATOM   1477 C CG2 . VAL A 1 190 ? 123.970 125.356 159.741 1.00 4.21  ? 218 VAL A CG2 1 
ATOM   1478 N N   . TYR A 1 191 ? 128.168 123.561 159.103 1.00 6.51  ? 219 TYR A N   1 
ATOM   1479 C CA  . TYR A 1 191 ? 129.294 123.093 158.308 1.00 6.51  ? 219 TYR A CA  1 
ATOM   1480 C C   . TYR A 1 191 ? 129.642 121.642 158.619 1.00 6.51  ? 219 TYR A C   1 
ATOM   1481 O O   . TYR A 1 191 ? 130.151 120.929 157.744 1.00 6.51  ? 219 TYR A O   1 
ATOM   1482 C CB  . TYR A 1 191 ? 130.498 124.001 158.522 1.00 6.51  ? 219 TYR A CB  1 
ATOM   1483 C CG  . TYR A 1 191 ? 131.410 124.057 157.329 1.00 6.51  ? 219 TYR A CG  1 
ATOM   1484 C CD1 . TYR A 1 191 ? 131.022 124.715 156.171 1.00 6.51  ? 219 TYR A CD1 1 
ATOM   1485 C CD2 . TYR A 1 191 ? 132.662 123.472 157.361 1.00 6.51  ? 219 TYR A CD2 1 
ATOM   1486 C CE1 . TYR A 1 191 ? 131.851 124.778 155.077 1.00 6.51  ? 219 TYR A CE1 1 
ATOM   1487 C CE2 . TYR A 1 191 ? 133.498 123.535 156.274 1.00 6.51  ? 219 TYR A CE2 1 
ATOM   1488 C CZ  . TYR A 1 191 ? 133.089 124.185 155.134 1.00 6.51  ? 219 TYR A CZ  1 
ATOM   1489 O OH  . TYR A 1 191 ? 133.926 124.243 154.048 1.00 6.51  ? 219 TYR A OH  1 
ATOM   1490 N N   . SER A 1 192 ? 129.354 121.173 159.836 1.00 3.66  ? 220 SER A N   1 
ATOM   1491 C CA  . SER A 1 192 ? 129.476 119.748 160.117 1.00 3.66  ? 220 SER A CA  1 
ATOM   1492 C C   . SER A 1 192 ? 128.500 118.943 159.272 1.00 3.66  ? 220 SER A C   1 
ATOM   1493 O O   . SER A 1 192 ? 128.849 117.880 158.745 1.00 3.66  ? 220 SER A O   1 
ATOM   1494 C CB  . SER A 1 192 ? 129.244 119.484 161.602 1.00 3.66  ? 220 SER A CB  1 
ATOM   1495 O OG  . SER A 1 192 ? 129.152 118.095 161.860 1.00 3.66  ? 220 SER A OG  1 
ATOM   1496 N N   . ARG A 1 193 ? 127.268 119.435 159.127 1.00 4.33  ? 221 ARG A N   1 
ATOM   1497 C CA  . ARG A 1 193 ? 126.319 118.756 158.248 1.00 4.33  ? 221 ARG A CA  1 
ATOM   1498 C C   . ARG A 1 193 ? 126.793 118.769 156.799 1.00 4.33  ? 221 ARG A C   1 
ATOM   1499 O O   . ARG A 1 193 ? 126.597 117.785 156.070 1.00 4.33  ? 221 ARG A O   1 
ATOM   1500 C CB  . ARG A 1 193 ? 124.930 119.378 158.375 1.00 4.33  ? 221 ARG A CB  1 
ATOM   1501 C CG  . ARG A 1 193 ? 124.097 118.735 159.472 1.00 4.33  ? 221 ARG A CG  1 
ATOM   1502 C CD  . ARG A 1 193 ? 122.964 119.629 159.933 1.00 4.33  ? 221 ARG A CD  1 
ATOM   1503 N NE  . ARG A 1 193 ? 121.916 119.765 158.928 1.00 4.33  ? 221 ARG A NE  1 
ATOM   1504 C CZ  . ARG A 1 193 ? 120.678 120.165 159.197 1.00 4.33  ? 221 ARG A CZ  1 
ATOM   1505 N NH1 . ARG A 1 193 ? 119.784 120.261 158.223 1.00 4.33  ? 221 ARG A NH1 1 
ATOM   1506 N NH2 . ARG A 1 193 ? 120.333 120.467 160.440 1.00 4.33  ? 221 ARG A NH2 1 
ATOM   1507 N N   . VAL A 1 194 ? 127.424 119.860 156.364 1.00 3.01  ? 222 VAL A N   1 
ATOM   1508 C CA  . VAL A 1 194 ? 127.967 119.901 155.008 1.00 3.01  ? 222 VAL A CA  1 
ATOM   1509 C C   . VAL A 1 194 ? 129.030 118.826 154.827 1.00 3.01  ? 222 VAL A C   1 
ATOM   1510 O O   . VAL A 1 194 ? 128.976 118.034 153.882 1.00 3.01  ? 222 VAL A O   1 
ATOM   1511 C CB  . VAL A 1 194 ? 128.521 121.296 154.680 1.00 3.01  ? 222 VAL A CB  1 
ATOM   1512 C CG1 . VAL A 1 194 ? 129.337 121.242 153.406 1.00 3.01  ? 222 VAL A CG1 1 
ATOM   1513 C CG2 . VAL A 1 194 ? 127.389 122.275 154.525 1.00 3.01  ? 222 VAL A CG2 1 
ATOM   1514 N N   . PHE A 1 195 ? 130.002 118.762 155.739 1.00 3.58  ? 223 PHE A N   1 
ATOM   1515 C CA  . PHE A 1 195 ? 131.002 117.701 155.614 1.00 3.58  ? 223 PHE A CA  1 
ATOM   1516 C C   . PHE A 1 195 ? 130.466 116.300 155.875 1.00 3.58  ? 223 PHE A C   1 
ATOM   1517 O O   . PHE A 1 195 ? 131.164 115.335 155.551 1.00 3.58  ? 223 PHE A O   1 
ATOM   1518 C CB  . PHE A 1 195 ? 132.214 117.944 156.513 1.00 3.58  ? 223 PHE A CB  1 
ATOM   1519 C CG  . PHE A 1 195 ? 133.143 119.007 156.009 1.00 3.58  ? 223 PHE A CG  1 
ATOM   1520 C CD1 . PHE A 1 195 ? 133.055 119.453 154.705 1.00 3.58  ? 223 PHE A CD1 1 
ATOM   1521 C CD2 . PHE A 1 195 ? 134.147 119.510 156.817 1.00 3.58  ? 223 PHE A CD2 1 
ATOM   1522 C CE1 . PHE A 1 195 ? 133.927 120.410 154.230 1.00 3.58  ? 223 PHE A CE1 1 
ATOM   1523 C CE2 . PHE A 1 195 ? 135.021 120.469 156.345 1.00 3.58  ? 223 PHE A CE2 1 
ATOM   1524 C CZ  . PHE A 1 195 ? 134.913 120.915 155.050 1.00 3.58  ? 223 PHE A CZ  1 
ATOM   1525 N N   . GLN A 1 196 ? 129.275 116.137 156.449 1.00 5.62  ? 224 GLN A N   1 
ATOM   1526 C CA  . GLN A 1 196 ? 128.731 114.786 156.517 1.00 5.62  ? 224 GLN A CA  1 
ATOM   1527 C C   . GLN A 1 196 ? 127.800 114.458 155.355 1.00 5.62  ? 224 GLN A C   1 
ATOM   1528 O O   . GLN A 1 196 ? 127.372 113.305 155.244 1.00 5.62  ? 224 GLN A O   1 
ATOM   1529 C CB  . GLN A 1 196 ? 127.999 114.531 157.844 1.00 5.62  ? 224 GLN A CB  1 
ATOM   1530 C CG  . GLN A 1 196 ? 126.777 115.377 158.100 1.00 5.62  ? 224 GLN A CG  1 
ATOM   1531 C CD  . GLN A 1 196 ? 125.528 114.816 157.448 1.00 5.62  ? 224 GLN A CD  1 
ATOM   1532 O OE1 . GLN A 1 196 ? 125.395 113.604 157.277 1.00 5.62  ? 224 GLN A OE1 1 
ATOM   1533 N NE2 . GLN A 1 196 ? 124.609 115.696 157.070 1.00 5.62  ? 224 GLN A NE2 1 
ATOM   1534 N N   . GLU A 1 197 ? 127.463 115.427 154.493 1.00 5.02  ? 225 GLU A N   1 
ATOM   1535 C CA  . GLU A 1 197 ? 126.829 115.073 153.228 1.00 5.02  ? 225 GLU A CA  1 
ATOM   1536 C C   . GLU A 1 197 ? 127.680 115.379 152.004 1.00 5.02  ? 225 GLU A C   1 
ATOM   1537 O O   . GLU A 1 197 ? 127.342 114.914 150.913 1.00 5.02  ? 225 GLU A O   1 
ATOM   1538 C CB  . GLU A 1 197 ? 125.473 115.771 153.049 1.00 5.02  ? 225 GLU A CB  1 
ATOM   1539 C CG  . GLU A 1 197 ? 125.520 117.274 152.916 1.00 5.02  ? 225 GLU A CG  1 
ATOM   1540 C CD  . GLU A 1 197 ? 124.131 117.875 152.804 1.00 5.02  ? 225 GLU A CD  1 
ATOM   1541 O OE1 . GLU A 1 197 ? 123.146 117.109 152.857 1.00 5.02  ? 225 GLU A OE1 1 
ATOM   1542 O OE2 . GLU A 1 197 ? 124.021 119.107 152.637 1.00 5.02  ? 225 GLU A OE2 1 
ATOM   1543 N N   . ALA A 1 198 ? 128.754 116.152 152.143 1.00 4.39  ? 226 ALA A N   1 
ATOM   1544 C CA  . ALA A 1 198 ? 129.699 116.328 151.049 1.00 4.39  ? 226 ALA A CA  1 
ATOM   1545 C C   . ALA A 1 198 ? 130.776 115.256 151.030 1.00 4.39  ? 226 ALA A C   1 
ATOM   1546 O O   . ALA A 1 198 ? 131.585 115.229 150.097 1.00 4.39  ? 226 ALA A O   1 
ATOM   1547 C CB  . ALA A 1 198 ? 130.358 117.706 151.116 1.00 4.39  ? 226 ALA A CB  1 
ATOM   1548 N N   . LYS A 1 199 ? 130.823 114.397 152.043 1.00 6.32  ? 227 LYS A N   1 
ATOM   1549 C CA  . LYS A 1 199 ? 131.642 113.196 152.017 1.00 6.32  ? 227 LYS A CA  1 
ATOM   1550 C C   . LYS A 1 199 ? 130.835 111.957 151.659 1.00 6.32  ? 227 LYS A C   1 
ATOM   1551 O O   . LYS A 1 199 ? 131.394 110.858 151.615 1.00 6.32  ? 227 LYS A O   1 
ATOM   1552 C CB  . LYS A 1 199 ? 132.336 112.994 153.366 1.00 6.32  ? 227 LYS A CB  1 
ATOM   1553 C CG  . LYS A 1 199 ? 133.616 113.796 153.522 1.00 6.32  ? 227 LYS A CG  1 
ATOM   1554 C CD  . LYS A 1 199 ? 134.648 113.404 152.475 1.00 6.32  ? 227 LYS A CD  1 
ATOM   1555 C CE  . LYS A 1 199 ? 135.337 112.096 152.832 1.00 6.32  ? 227 LYS A CE  1 
ATOM   1556 N NZ  . LYS A 1 199 ? 136.465 111.794 151.909 1.00 6.32  ? 227 LYS A NZ  1 
ATOM   1557 N N   . ARG A 1 200 ? 129.535 112.111 151.411 1.00 10.83 ? 228 ARG A N   1 
ATOM   1558 C CA  . ARG A 1 200 ? 128.692 111.031 150.919 1.00 10.83 ? 228 ARG A CA  1 
ATOM   1559 C C   . ARG A 1 200 ? 128.522 111.060 149.408 1.00 10.83 ? 228 ARG A C   1 
ATOM   1560 O O   . ARG A 1 200 ? 128.455 109.997 148.782 1.00 10.83 ? 228 ARG A O   1 
ATOM   1561 C CB  . ARG A 1 200 ? 127.314 111.092 151.588 1.00 10.83 ? 228 ARG A CB  1 
ATOM   1562 C CG  . ARG A 1 200 ? 126.208 110.392 150.818 1.00 10.83 ? 228 ARG A CG  1 
ATOM   1563 C CD  . ARG A 1 200 ? 124.858 111.023 151.093 1.00 10.83 ? 228 ARG A CD  1 
ATOM   1564 N NE  . ARG A 1 200 ? 124.570 111.087 152.520 1.00 10.83 ? 228 ARG A NE  1 
ATOM   1565 C CZ  . ARG A 1 200 ? 123.497 111.675 153.036 1.00 10.83 ? 228 ARG A CZ  1 
ATOM   1566 N NH1 . ARG A 1 200 ? 122.610 112.251 152.238 1.00 10.83 ? 228 ARG A NH1 1 
ATOM   1567 N NH2 . ARG A 1 200 ? 123.312 111.687 154.348 1.00 10.83 ? 228 ARG A NH2 1 
ATOM   1568 N N   . GLN A 1 201 ? 128.477 112.253 148.809 1.00 11.13 ? 229 GLN A N   1 
ATOM   1569 C CA  . GLN A 1 201 ? 128.366 112.358 147.359 1.00 11.13 ? 229 GLN A CA  1 
ATOM   1570 C C   . GLN A 1 201 ? 129.547 111.707 146.656 1.00 11.13 ? 229 GLN A C   1 
ATOM   1571 O O   . GLN A 1 201 ? 129.430 111.303 145.494 1.00 11.13 ? 229 GLN A O   1 
ATOM   1572 C CB  . GLN A 1 201 ? 128.249 113.824 146.946 1.00 11.13 ? 229 GLN A CB  1 
ATOM   1573 C CG  . GLN A 1 201 ? 126.904 114.448 147.260 1.00 11.13 ? 229 GLN A CG  1 
ATOM   1574 C CD  . GLN A 1 201 ? 126.692 115.761 146.538 1.00 11.13 ? 229 GLN A CD  1 
ATOM   1575 O OE1 . GLN A 1 201 ? 127.627 116.335 145.981 1.00 11.13 ? 229 GLN A OE1 1 
ATOM   1576 N NE2 . GLN A 1 201 ? 125.456 116.244 146.543 1.00 11.13 ? 229 GLN A NE2 1 
ATOM   1577 N N   . LEU A 1 202 ? 130.688 111.596 147.333 1.00 11.06 ? 230 LEU A N   1 
ATOM   1578 C CA  . LEU A 1 202 ? 131.837 110.877 146.803 1.00 11.06 ? 230 LEU A CA  1 
ATOM   1579 C C   . LEU A 1 202 ? 131.747 109.374 147.037 1.00 11.06 ? 230 LEU A C   1 
ATOM   1580 O O   . LEU A 1 202 ? 132.759 108.673 146.911 1.00 11.06 ? 230 LEU A O   1 
ATOM   1581 C CB  . LEU A 1 202 ? 133.134 111.421 147.406 1.00 11.06 ? 230 LEU A CB  1 
ATOM   1582 C CG  . LEU A 1 202 ? 133.784 112.634 146.734 1.00 11.06 ? 230 LEU A CG  1 
ATOM   1583 C CD1 . LEU A 1 202 ? 132.824 113.808 146.620 1.00 11.06 ? 230 LEU A CD1 1 
ATOM   1584 C CD2 . LEU A 1 202 ? 135.045 113.041 147.479 1.00 11.06 ? 230 LEU A CD2 1 
ATOM   1585 N N   . ASP A 1 203 ? 130.566 108.874 147.388 1.00 14.24 ? 231 ASP A N   1 
ATOM   1586 C CA  . ASP A 1 203 ? 130.320 107.447 147.562 1.00 14.24 ? 231 ASP A CA  1 
ATOM   1587 C C   . ASP A 1 203 ? 128.992 107.082 146.905 1.00 14.24 ? 231 ASP A C   1 
ATOM   1588 O O   . ASP A 1 203 ? 128.151 106.390 147.478 1.00 14.24 ? 231 ASP A O   1 
ATOM   1589 C CB  . ASP A 1 203 ? 130.338 107.071 149.043 1.00 14.24 ? 231 ASP A CB  1 
ATOM   1590 C CG  . ASP A 1 203 ? 130.346 105.572 149.266 1.00 14.24 ? 231 ASP A CG  1 
ATOM   1591 O OD1 . ASP A 1 203 ? 129.869 105.126 150.331 1.00 14.24 ? 231 ASP A OD1 1 
ATOM   1592 O OD2 . ASP A 1 203 ? 130.823 104.840 148.374 1.00 14.24 ? 231 ASP A OD2 1 
ATOM   1593 N N   . ALA A 1 204 ? 128.792 107.561 145.680 1.00 15.47 ? 232 ALA A N   1 
ATOM   1594 C CA  . ALA A 1 204 ? 127.528 107.408 144.975 1.00 15.47 ? 232 ALA A CA  1 
ATOM   1595 C C   . ALA A 1 204 ? 127.522 106.226 144.016 1.00 15.47 ? 232 ALA A C   1 
ATOM   1596 O O   . ALA A 1 204 ? 126.617 106.125 143.181 1.00 15.47 ? 232 ALA A O   1 
ATOM   1597 C CB  . ALA A 1 204 ? 127.191 108.694 144.219 1.00 15.47 ? 232 ALA A CB  1 
ATOM   1598 N N   . ASP A 1 205 ? 128.517 105.343 144.105 1.00 16.88 ? 233 ASP A N   1 
ATOM   1599 C CA  . ASP A 1 205 ? 128.709 104.162 143.264 1.00 16.88 ? 233 ASP A CA  1 
ATOM   1600 C C   . ASP A 1 205 ? 129.075 104.513 141.828 1.00 16.88 ? 233 ASP A C   1 
ATOM   1601 O O   . ASP A 1 205 ? 129.333 103.602 141.032 1.00 16.88 ? 233 ASP A O   1 
ATOM   1602 C CB  . ASP A 1 205 ? 127.485 103.235 143.254 1.00 16.88 ? 233 ASP A CB  1 
ATOM   1603 C CG  . ASP A 1 205 ? 127.371 102.410 144.517 1.00 16.88 ? 233 ASP A CG  1 
ATOM   1604 O OD1 . ASP A 1 205 ? 128.421 102.057 145.093 1.00 16.88 ? 233 ASP A OD1 1 
ATOM   1605 O OD2 . ASP A 1 205 ? 126.233 102.116 144.937 1.00 16.88 ? 233 ASP A OD2 1 
ATOM   1606 N N   . GLU A 1 206 ? 129.107 105.793 141.465 1.00 13.95 ? 234 GLU A N   1 
ATOM   1607 C CA  . GLU A 1 206 ? 129.651 106.230 140.187 1.00 13.95 ? 234 GLU A CA  1 
ATOM   1608 C C   . GLU A 1 206 ? 131.127 106.578 140.295 1.00 13.95 ? 234 GLU A C   1 
ATOM   1609 O O   . GLU A 1 206 ? 131.945 106.074 139.521 1.00 13.95 ? 234 GLU A O   1 
ATOM   1610 C CB  . GLU A 1 206 ? 128.878 107.442 139.657 1.00 13.95 ? 234 GLU A CB  1 
ATOM   1611 C CG  . GLU A 1 206 ? 127.448 107.154 139.270 1.00 13.95 ? 234 GLU A CG  1 
ATOM   1612 C CD  . GLU A 1 206 ? 126.736 108.390 138.772 1.00 13.95 ? 234 GLU A CD  1 
ATOM   1613 O OE1 . GLU A 1 206 ? 127.330 109.486 138.852 1.00 13.95 ? 234 GLU A OE1 1 
ATOM   1614 O OE2 . GLU A 1 206 ? 125.587 108.269 138.301 1.00 13.95 ? 234 GLU A OE2 1 
ATOM   1615 N N   . ILE A 1 207 ? 131.481 107.435 141.255 1.00 11.38 ? 235 ILE A N   1 
ATOM   1616 C CA  . ILE A 1 207 ? 132.880 107.785 141.467 1.00 11.38 ? 235 ILE A CA  1 
ATOM   1617 C C   . ILE A 1 207 ? 133.678 106.555 141.877 1.00 11.38 ? 235 ILE A C   1 
ATOM   1618 O O   . ILE A 1 207 ? 134.888 106.488 141.643 1.00 11.38 ? 235 ILE A O   1 
ATOM   1619 C CB  . ILE A 1 207 ? 132.998 108.932 142.494 1.00 11.38 ? 235 ILE A CB  1 
ATOM   1620 C CG1 . ILE A 1 207 ? 132.319 110.201 141.970 1.00 11.38 ? 235 ILE A CG1 1 
ATOM   1621 C CG2 . ILE A 1 207 ? 134.446 109.250 142.798 1.00 11.38 ? 235 ILE A CG2 1 
ATOM   1622 C CD1 . ILE A 1 207 ? 130.851 110.322 142.305 1.00 11.38 ? 235 ILE A CD1 1 
ATOM   1623 N N   . LYS A 1 208 ? 133.021 105.555 142.469 1.00 13.69 ? 236 LYS A N   1 
ATOM   1624 C CA  . LYS A 1 208 ? 133.697 104.283 142.711 1.00 13.69 ? 236 LYS A CA  1 
ATOM   1625 C C   . LYS A 1 208 ? 134.085 103.605 141.401 1.00 13.69 ? 236 LYS A C   1 
ATOM   1626 O O   . LYS A 1 208 ? 135.184 103.049 141.280 1.00 13.69 ? 236 LYS A O   1 
ATOM   1627 C CB  . LYS A 1 208 ? 132.810 103.361 143.545 1.00 13.69 ? 236 LYS A CB  1 
ATOM   1628 C CG  . LYS A 1 208 ? 133.112 103.383 145.032 1.00 13.69 ? 236 LYS A CG  1 
ATOM   1629 C CD  . LYS A 1 208 ? 132.662 102.091 145.692 1.00 13.69 ? 236 LYS A CD  1 
ATOM   1630 C CE  . LYS A 1 208 ? 133.020 102.069 147.165 1.00 13.69 ? 236 LYS A CE  1 
ATOM   1631 N NZ  . LYS A 1 208 ? 132.189 103.023 147.945 1.00 13.69 ? 236 LYS A NZ  1 
ATOM   1632 N N   . ARG A 1 209 ? 133.191 103.629 140.410 1.00 12.82 ? 237 ARG A N   1 
ATOM   1633 C CA  . ARG A 1 209 ? 133.517 103.040 139.116 1.00 12.82 ? 237 ARG A CA  1 
ATOM   1634 C C   . ARG A 1 209 ? 134.650 103.795 138.438 1.00 12.82 ? 237 ARG A C   1 
ATOM   1635 O O   . ARG A 1 209 ? 135.539 103.182 137.835 1.00 12.82 ? 237 ARG A O   1 
ATOM   1636 C CB  . ARG A 1 209 ? 132.281 103.007 138.219 1.00 12.82 ? 237 ARG A CB  1 
ATOM   1637 C CG  . ARG A 1 209 ? 131.321 101.872 138.527 1.00 12.82 ? 237 ARG A CG  1 
ATOM   1638 C CD  . ARG A 1 209 ? 130.488 101.513 137.309 1.00 12.82 ? 237 ARG A CD  1 
ATOM   1639 N NE  . ARG A 1 209 ? 129.683 102.640 136.848 1.00 12.82 ? 237 ARG A NE  1 
ATOM   1640 C CZ  . ARG A 1 209 ? 128.463 102.917 137.291 1.00 12.82 ? 237 ARG A CZ  1 
ATOM   1641 N NH1 . ARG A 1 209 ? 127.805 103.964 136.813 1.00 12.82 ? 237 ARG A NH1 1 
ATOM   1642 N NH2 . ARG A 1 209 ? 127.900 102.149 138.213 1.00 12.82 ? 237 ARG A NH2 1 
ATOM   1643 N N   . LEU A 1 210 ? 134.639 105.127 138.522 1.00 9.10  ? 238 LEU A N   1 
ATOM   1644 C CA  . LEU A 1 210 ? 135.750 105.893 137.970 1.00 9.10  ? 238 LEU A CA  1 
ATOM   1645 C C   . LEU A 1 210 ? 137.039 105.643 138.741 1.00 9.10  ? 238 LEU A C   1 
ATOM   1646 O O   . LEU A 1 210 ? 138.123 105.713 138.160 1.00 9.10  ? 238 LEU A O   1 
ATOM   1647 C CB  . LEU A 1 210 ? 135.419 107.385 137.943 1.00 9.10  ? 238 LEU A CB  1 
ATOM   1648 C CG  . LEU A 1 210 ? 134.636 107.884 136.724 1.00 9.10  ? 238 LEU A CG  1 
ATOM   1649 C CD1 . LEU A 1 210 ? 133.176 107.469 136.788 1.00 9.10  ? 238 LEU A CD1 1 
ATOM   1650 C CD2 . LEU A 1 210 ? 134.766 109.390 136.577 1.00 9.10  ? 238 LEU A CD2 1 
ATOM   1651 N N   . GLY A 1 211 ? 136.947 105.339 140.036 1.00 10.70 ? 239 GLY A N   1 
ATOM   1652 C CA  . GLY A 1 211 ? 138.135 104.946 140.776 1.00 10.70 ? 239 GLY A CA  1 
ATOM   1653 C C   . GLY A 1 211 ? 138.689 103.614 140.310 1.00 10.70 ? 239 GLY A C   1 
ATOM   1654 O O   . GLY A 1 211 ? 139.905 103.438 140.199 1.00 10.70 ? 239 GLY A O   1 
ATOM   1655 N N   . LYS A 1 212 ? 137.803 102.657 140.035 1.00 11.44 ? 240 LYS A N   1 
ATOM   1656 C CA  . LYS A 1 212 ? 138.246 101.393 139.455 1.00 11.44 ? 240 LYS A CA  1 
ATOM   1657 C C   . LYS A 1 212 ? 138.898 101.618 138.096 1.00 11.44 ? 240 LYS A C   1 
ATOM   1658 O O   . LYS A 1 212 ? 139.934 101.019 137.785 1.00 11.44 ? 240 LYS A O   1 
ATOM   1659 C CB  . LYS A 1 212 ? 137.068 100.427 139.335 1.00 11.44 ? 240 LYS A CB  1 
ATOM   1660 C CG  . LYS A 1 212 ? 137.436 98.967  139.550 1.00 11.44 ? 240 LYS A CG  1 
ATOM   1661 C CD  . LYS A 1 212 ? 136.199 98.083  139.602 1.00 11.44 ? 240 LYS A CD  1 
ATOM   1662 C CE  . LYS A 1 212 ? 135.147 98.644  140.547 1.00 11.44 ? 240 LYS A CE  1 
ATOM   1663 N NZ  . LYS A 1 212 ? 135.593 98.607  141.966 1.00 11.44 ? 240 LYS A NZ  1 
ATOM   1664 N N   . ARG A 1 213 ? 138.304 102.488 137.278 1.00 9.47  ? 241 ARG A N   1 
ATOM   1665 C CA  . ARG A 1 213 ? 138.893 102.824 135.985 1.00 9.47  ? 241 ARG A CA  1 
ATOM   1666 C C   . ARG A 1 213 ? 140.259 103.477 136.155 1.00 9.47  ? 241 ARG A C   1 
ATOM   1667 O O   . ARG A 1 213 ? 141.196 103.183 135.405 1.00 9.47  ? 241 ARG A O   1 
ATOM   1668 C CB  . ARG A 1 213 ? 137.950 103.745 135.208 1.00 9.47  ? 241 ARG A CB  1 
ATOM   1669 C CG  . ARG A 1 213 ? 138.440 104.136 133.823 1.00 9.47  ? 241 ARG A CG  1 
ATOM   1670 C CD  . ARG A 1 213 ? 138.256 103.008 132.826 1.00 9.47  ? 241 ARG A CD  1 
ATOM   1671 N NE  . ARG A 1 213 ? 139.237 103.072 131.747 1.00 9.47  ? 241 ARG A NE  1 
ATOM   1672 C CZ  . ARG A 1 213 ? 139.497 102.070 130.916 1.00 9.47  ? 241 ARG A CZ  1 
ATOM   1673 N NH1 . ARG A 1 213 ? 138.847 100.921 131.036 1.00 9.47  ? 241 ARG A NH1 1 
ATOM   1674 N NH2 . ARG A 1 213 ? 140.407 102.214 129.964 1.00 9.47  ? 241 ARG A NH2 1 
ATOM   1675 N N   . PHE A 1 214 ? 140.385 104.370 137.136 1.00 10.44 ? 242 PHE A N   1 
ATOM   1676 C CA  . PHE A 1 214 ? 141.653 105.039 137.396 1.00 10.44 ? 242 PHE A CA  1 
ATOM   1677 C C   . PHE A 1 214 ? 142.723 104.043 137.816 1.00 10.44 ? 242 PHE A C   1 
ATOM   1678 O O   . PHE A 1 214 ? 143.875 104.133 137.377 1.00 10.44 ? 242 PHE A O   1 
ATOM   1679 C CB  . PHE A 1 214 ? 141.448 106.099 138.475 1.00 10.44 ? 242 PHE A CB  1 
ATOM   1680 C CG  . PHE A 1 214 ? 142.675 106.886 138.799 1.00 10.44 ? 242 PHE A CG  1 
ATOM   1681 C CD1 . PHE A 1 214 ? 143.120 107.874 137.949 1.00 10.44 ? 242 PHE A CD1 1 
ATOM   1682 C CD2 . PHE A 1 214 ? 143.379 106.641 139.958 1.00 10.44 ? 242 PHE A CD2 1 
ATOM   1683 C CE1 . PHE A 1 214 ? 144.243 108.605 138.251 1.00 10.44 ? 242 PHE A CE1 1 
ATOM   1684 C CE2 . PHE A 1 214 ? 144.504 107.367 140.262 1.00 10.44 ? 242 PHE A CE2 1 
ATOM   1685 C CZ  . PHE A 1 214 ? 144.937 108.350 139.407 1.00 10.44 ? 242 PHE A CZ  1 
ATOM   1686 N N   . LYS A 1 215 ? 142.360 103.089 138.676 1.00 10.72 ? 243 LYS A N   1 
ATOM   1687 C CA  . LYS A 1 215 ? 143.309 102.060 139.091 1.00 10.72 ? 243 LYS A CA  1 
ATOM   1688 C C   . LYS A 1 215 ? 143.706 101.169 137.921 1.00 10.72 ? 243 LYS A C   1 
ATOM   1689 O O   . LYS A 1 215 ? 144.872 100.777 137.800 1.00 10.72 ? 243 LYS A O   1 
ATOM   1690 C CB  . LYS A 1 215 ? 142.718 101.222 140.222 1.00 10.72 ? 243 LYS A CB  1 
ATOM   1691 C CG  . LYS A 1 215 ? 143.037 101.744 141.610 1.00 10.72 ? 243 LYS A CG  1 
ATOM   1692 C CD  . LYS A 1 215 ? 142.632 100.746 142.681 1.00 10.72 ? 243 LYS A CD  1 
ATOM   1693 C CE  . LYS A 1 215 ? 143.047 101.222 144.062 1.00 10.72 ? 243 LYS A CE  1 
ATOM   1694 N NZ  . LYS A 1 215 ? 142.693 102.651 144.285 1.00 10.72 ? 243 LYS A NZ  1 
ATOM   1695 N N   . LYS A 1 216 ? 142.748 100.830 137.055 1.00 11.93 ? 244 LYS A N   1 
ATOM   1696 C CA  . LYS A 1 216 ? 143.060 99.999  135.896 1.00 11.93 ? 244 LYS A CA  1 
ATOM   1697 C C   . LYS A 1 216 ? 143.969 100.728 134.916 1.00 11.93 ? 244 LYS A C   1 
ATOM   1698 O O   . LYS A 1 216 ? 144.871 100.121 134.327 1.00 11.93 ? 244 LYS A O   1 
ATOM   1699 C CB  . LYS A 1 216 ? 141.772 99.564  135.201 1.00 11.93 ? 244 LYS A CB  1 
ATOM   1700 C CG  . LYS A 1 216 ? 141.987 98.591  134.056 1.00 11.93 ? 244 LYS A CG  1 
ATOM   1701 C CD  . LYS A 1 216 ? 140.696 98.345  133.295 1.00 11.93 ? 244 LYS A CD  1 
ATOM   1702 C CE  . LYS A 1 216 ? 139.729 97.498  134.101 1.00 11.93 ? 244 LYS A CE  1 
ATOM   1703 N NZ  . LYS A 1 216 ? 138.502 97.182  133.322 1.00 11.93 ? 244 LYS A NZ  1 
ATOM   1704 N N   . LEU A 1 217 ? 143.743 102.029 134.723 1.00 10.48 ? 245 LEU A N   1 
ATOM   1705 C CA  . LEU A 1 217 ? 144.492 102.773 133.715 1.00 10.48 ? 245 LEU A CA  1 
ATOM   1706 C C   . LEU A 1 217 ? 145.948 102.964 134.123 1.00 10.48 ? 245 LEU A C   1 
ATOM   1707 O O   . LEU A 1 217 ? 146.852 102.834 133.290 1.00 10.48 ? 245 LEU A O   1 
ATOM   1708 C CB  . LEU A 1 217 ? 143.823 104.123 133.460 1.00 10.48 ? 245 LEU A CB  1 
ATOM   1709 C CG  . LEU A 1 217 ? 144.513 105.052 132.459 1.00 10.48 ? 245 LEU A CG  1 
ATOM   1710 C CD1 . LEU A 1 217 ? 144.592 104.402 131.089 1.00 10.48 ? 245 LEU A CD1 1 
ATOM   1711 C CD2 . LEU A 1 217 ? 143.796 106.387 132.382 1.00 10.48 ? 245 LEU A CD2 1 
ATOM   1712 N N   . ASP A 1 218 ? 146.197 103.273 135.393 1.00 12.93 ? 246 ASP A N   1 
ATOM   1713 C CA  . ASP A 1 218 ? 147.555 103.550 135.842 1.00 12.93 ? 246 ASP A CA  1 
ATOM   1714 C C   . ASP A 1 218 ? 148.413 102.294 135.761 1.00 12.93 ? 246 ASP A C   1 
ATOM   1715 O O   . ASP A 1 218 ? 147.980 101.205 136.150 1.00 12.93 ? 246 ASP A O   1 
ATOM   1716 C CB  . ASP A 1 218 ? 147.542 104.092 137.268 1.00 12.93 ? 246 ASP A CB  1 
ATOM   1717 C CG  . ASP A 1 218 ? 148.783 104.892 137.594 1.00 12.93 ? 246 ASP A CG  1 
ATOM   1718 O OD1 . ASP A 1 218 ? 149.071 105.091 138.792 1.00 12.93 ? 246 ASP A OD1 1 
ATOM   1719 O OD2 . ASP A 1 218 ? 149.475 105.318 136.648 1.00 12.93 ? 246 ASP A OD2 1 
ATOM   1720 N N   . LEU A 1 219 ? 149.636 102.449 135.254 1.00 13.89 ? 247 LEU A N   1 
ATOM   1721 C CA  . LEU A 1 219 ? 150.556 101.330 135.086 1.00 13.89 ? 247 LEU A CA  1 
ATOM   1722 C C   . LEU A 1 219 ? 151.506 101.184 136.271 1.00 13.89 ? 247 LEU A C   1 
ATOM   1723 O O   . LEU A 1 219 ? 151.579 100.115 136.885 1.00 13.89 ? 247 LEU A O   1 
ATOM   1724 C CB  . LEU A 1 219 ? 151.357 101.501 133.791 1.00 13.89 ? 247 LEU A CB  1 
ATOM   1725 C CG  . LEU A 1 219 ? 150.714 101.005 132.495 1.00 13.89 ? 247 LEU A CG  1 
ATOM   1726 C CD1 . LEU A 1 219 ? 149.693 102.003 131.975 1.00 13.89 ? 247 LEU A CD1 1 
ATOM   1727 C CD2 . LEU A 1 219 ? 151.780 100.735 131.448 1.00 13.89 ? 247 LEU A CD2 1 
ATOM   1728 N N   . ASP A 1 220 ? 152.236 102.250 136.603 1.00 15.55 ? 248 ASP A N   1 
ATOM   1729 C CA  . ASP A 1 220 ? 153.216 102.205 137.681 1.00 15.55 ? 248 ASP A CA  1 
ATOM   1730 C C   . ASP A 1 220 ? 152.580 102.101 139.060 1.00 15.55 ? 248 ASP A C   1 
ATOM   1731 O O   . ASP A 1 220 ? 153.300 101.850 140.033 1.00 15.55 ? 248 ASP A O   1 
ATOM   1732 C CB  . ASP A 1 220 ? 154.109 103.444 137.619 1.00 15.55 ? 248 ASP A CB  1 
ATOM   1733 C CG  . ASP A 1 220 ? 153.314 104.729 137.488 1.00 15.55 ? 248 ASP A CG  1 
ATOM   1734 O OD1 . ASP A 1 220 ? 152.068 104.664 137.520 1.00 15.55 ? 248 ASP A OD1 1 
ATOM   1735 O OD2 . ASP A 1 220 ? 153.933 105.804 137.350 1.00 15.55 ? 248 ASP A OD2 1 
ATOM   1736 N N   . ASN A 1 221 ? 151.265 102.292 139.165 1.00 16.81 ? 249 ASN A N   1 
ATOM   1737 C CA  . ASN A 1 221 ? 150.551 102.247 140.442 1.00 16.81 ? 249 ASN A CA  1 
ATOM   1738 C C   . ASN A 1 221 ? 151.132 103.251 141.434 1.00 16.81 ? 249 ASN A C   1 
ATOM   1739 O O   . ASN A 1 221 ? 151.248 102.977 142.630 1.00 16.81 ? 249 ASN A O   1 
ATOM   1740 C CB  . ASN A 1 221 ? 150.550 100.834 141.029 1.00 16.81 ? 249 ASN A CB  1 
ATOM   1741 C CG  . ASN A 1 221 ? 149.227 100.473 141.678 1.00 16.81 ? 249 ASN A CG  1 
ATOM   1742 O OD1 . ASN A 1 221 ? 148.330 101.308 141.790 1.00 16.81 ? 249 ASN A OD1 1 
ATOM   1743 N ND2 . ASN A 1 221 ? 149.098 99.222  142.105 1.00 16.81 ? 249 ASN A ND2 1 
ATOM   1744 N N   . SER A 1 222 ? 151.504 104.426 140.931 1.00 14.82 ? 250 SER A N   1 
ATOM   1745 C CA  . SER A 1 222 ? 152.019 105.507 141.758 1.00 14.82 ? 250 SER A CA  1 
ATOM   1746 C C   . SER A 1 222 ? 150.962 106.547 142.098 1.00 14.82 ? 250 SER A C   1 
ATOM   1747 O O   . SER A 1 222 ? 151.279 107.536 142.764 1.00 14.82 ? 250 SER A O   1 
ATOM   1748 C CB  . SER A 1 222 ? 153.201 106.187 141.064 1.00 14.82 ? 250 SER A CB  1 
ATOM   1749 O OG  . SER A 1 222 ? 153.696 107.258 141.847 1.00 14.82 ? 250 SER A OG  1 
ATOM   1750 N N   . GLY A 1 223 ? 149.721 106.352 141.658 1.00 12.72 ? 251 GLY A N   1 
ATOM   1751 C CA  . GLY A 1 223 ? 148.660 107.299 141.931 1.00 12.72 ? 251 GLY A CA  1 
ATOM   1752 C C   . GLY A 1 223 ? 148.629 108.511 141.031 1.00 12.72 ? 251 GLY A C   1 
ATOM   1753 O O   . GLY A 1 223 ? 147.894 109.460 141.326 1.00 12.72 ? 251 GLY A O   1 
ATOM   1754 N N   . SER A 1 224 ? 149.397 108.515 139.944 1.00 12.15 ? 252 SER A N   1 
ATOM   1755 C CA  . SER A 1 224 ? 149.472 109.661 139.051 1.00 12.15 ? 252 SER A CA  1 
ATOM   1756 C C   . SER A 1 224 ? 149.346 109.193 137.610 1.00 12.15 ? 252 SER A C   1 
ATOM   1757 O O   . SER A 1 224 ? 149.686 108.055 137.278 1.00 12.15 ? 252 SER A O   1 
ATOM   1758 C CB  . SER A 1 224 ? 150.785 110.431 139.231 1.00 12.15 ? 252 SER A CB  1 
ATOM   1759 O OG  . SER A 1 224 ? 151.896 109.621 138.887 1.00 12.15 ? 252 SER A OG  1 
ATOM   1760 N N   . LEU A 1 225 ? 148.852 110.086 136.755 1.00 9.97  ? 253 LEU A N   1 
ATOM   1761 C CA  . LEU A 1 225 ? 148.711 109.827 135.327 1.00 9.97  ? 253 LEU A CA  1 
ATOM   1762 C C   . LEU A 1 225 ? 149.579 110.807 134.548 1.00 9.97  ? 253 LEU A C   1 
ATOM   1763 O O   . LEU A 1 225 ? 149.372 112.022 134.627 1.00 9.97  ? 253 LEU A O   1 
ATOM   1764 C CB  . LEU A 1 225 ? 147.252 109.944 134.889 1.00 9.97  ? 253 LEU A CB  1 
ATOM   1765 C CG  . LEU A 1 225 ? 146.299 108.859 135.375 1.00 9.97  ? 253 LEU A CG  1 
ATOM   1766 C CD1 . LEU A 1 225 ? 144.918 109.094 134.804 1.00 9.97  ? 253 LEU A CD1 1 
ATOM   1767 C CD2 . LEU A 1 225 ? 146.822 107.500 134.976 1.00 9.97  ? 253 LEU A CD2 1 
ATOM   1768 N N   . SER A 1 226 ? 150.526 110.276 133.781 1.00 11.58 ? 254 SER A N   1 
ATOM   1769 C CA  . SER A 1 226 ? 151.430 111.081 132.977 1.00 11.58 ? 254 SER A CA  1 
ATOM   1770 C C   . SER A 1 226 ? 150.999 111.047 131.513 1.00 11.58 ? 254 SER A C   1 
ATOM   1771 O O   . SER A 1 226 ? 150.042 110.370 131.134 1.00 11.58 ? 254 SER A O   1 
ATOM   1772 C CB  . SER A 1 226 ? 152.867 110.587 133.141 1.00 11.58 ? 254 SER A CB  1 
ATOM   1773 O OG  . SER A 1 226 ? 152.979 109.229 132.756 1.00 11.58 ? 254 SER A OG  1 
ATOM   1774 N N   . VAL A 1 227 ? 151.727 111.789 130.676 1.00 9.76  ? 255 VAL A N   1 
ATOM   1775 C CA  . VAL A 1 227 ? 151.381 111.859 129.259 1.00 9.76  ? 255 VAL A CA  1 
ATOM   1776 C C   . VAL A 1 227 ? 151.590 110.507 128.588 1.00 9.76  ? 255 VAL A C   1 
ATOM   1777 O O   . VAL A 1 227 ? 150.809 110.103 127.718 1.00 9.76  ? 255 VAL A O   1 
ATOM   1778 C CB  . VAL A 1 227 ? 152.188 112.971 128.566 1.00 9.76  ? 255 VAL A CB  1 
ATOM   1779 C CG1 . VAL A 1 227 ? 151.795 113.079 127.103 1.00 9.76  ? 255 VAL A CG1 1 
ATOM   1780 C CG2 . VAL A 1 227 ? 151.971 114.297 129.272 1.00 9.76  ? 255 VAL A CG2 1 
ATOM   1781 N N   . GLU A 1 228 ? 152.639 109.782 128.983 1.00 11.04 ? 256 GLU A N   1 
ATOM   1782 C CA  . GLU A 1 228 ? 152.873 108.459 128.413 1.00 11.04 ? 256 GLU A CA  1 
ATOM   1783 C C   . GLU A 1 228 ? 151.719 107.515 128.723 1.00 11.04 ? 256 GLU A C   1 
ATOM   1784 O O   . GLU A 1 228 ? 151.349 106.679 127.890 1.00 11.04 ? 256 GLU A O   1 
ATOM   1785 C CB  . GLU A 1 228 ? 154.190 107.888 128.938 1.00 11.04 ? 256 GLU A CB  1 
ATOM   1786 C CG  . GLU A 1 228 ? 154.556 106.523 128.370 1.00 11.04 ? 256 GLU A CG  1 
ATOM   1787 C CD  . GLU A 1 228 ? 153.980 105.379 129.180 1.00 11.04 ? 256 GLU A CD  1 
ATOM   1788 O OE1 . GLU A 1 228 ? 153.654 105.596 130.365 1.00 11.04 ? 256 GLU A OE1 1 
ATOM   1789 O OE2 . GLU A 1 228 ? 153.850 104.265 128.633 1.00 11.04 ? 256 GLU A OE2 1 
ATOM   1790 N N   . GLU A 1 229 ? 151.140 107.631 129.918 1.00 10.52 ? 257 GLU A N   1 
ATOM   1791 C CA  . GLU A 1 229 ? 150.070 106.720 130.307 1.00 10.52 ? 257 GLU A CA  1 
ATOM   1792 C C   . GLU A 1 229 ? 148.762 107.038 129.592 1.00 10.52 ? 257 GLU A C   1 
ATOM   1793 O O   . GLU A 1 229 ? 147.973 106.125 129.325 1.00 10.52 ? 257 GLU A O   1 
ATOM   1794 C CB  . GLU A 1 229 ? 149.898 106.751 131.823 1.00 10.52 ? 257 GLU A CB  1 
ATOM   1795 C CG  . GLU A 1 229 ? 151.182 106.400 132.557 1.00 10.52 ? 257 GLU A CG  1 
ATOM   1796 C CD  . GLU A 1 229 ? 151.103 106.663 134.041 1.00 10.52 ? 257 GLU A CD  1 
ATOM   1797 O OE1 . GLU A 1 229 ? 150.062 107.173 134.494 1.00 10.52 ? 257 GLU A OE1 1 
ATOM   1798 O OE2 . GLU A 1 229 ? 152.083 106.360 134.754 1.00 10.52 ? 257 GLU A OE2 1 
ATOM   1799 N N   . PHE A 1 230 ? 148.505 108.311 129.277 1.00 8.75  ? 258 PHE A N   1 
ATOM   1800 C CA  . PHE A 1 230 ? 147.407 108.616 128.365 1.00 8.75  ? 258 PHE A CA  1 
ATOM   1801 C C   . PHE A 1 230 ? 147.704 108.152 126.947 1.00 8.75  ? 258 PHE A C   1 
ATOM   1802 O O   . PHE A 1 230 ? 146.780 107.787 126.213 1.00 8.75  ? 258 PHE A O   1 
ATOM   1803 C CB  . PHE A 1 230 ? 147.088 110.109 128.358 1.00 8.75  ? 258 PHE A CB  1 
ATOM   1804 C CG  . PHE A 1 230 ? 146.451 110.606 129.616 1.00 8.75  ? 258 PHE A CG  1 
ATOM   1805 C CD1 . PHE A 1 230 ? 145.098 110.415 129.830 1.00 8.75  ? 258 PHE A CD1 1 
ATOM   1806 C CD2 . PHE A 1 230 ? 147.180 111.293 130.559 1.00 8.75  ? 258 PHE A CD2 1 
ATOM   1807 C CE1 . PHE A 1 230 ? 144.492 110.879 130.970 1.00 8.75  ? 258 PHE A CE1 1 
ATOM   1808 C CE2 . PHE A 1 230 ? 146.577 111.761 131.704 1.00 8.75  ? 258 PHE A CE2 1 
ATOM   1809 C CZ  . PHE A 1 230 ? 145.230 111.552 131.909 1.00 8.75  ? 258 PHE A CZ  1 
ATOM   1810 N N   . MET A 1 231 ? 148.969 108.164 126.539 1.00 10.30 ? 259 MET A N   1 
ATOM   1811 C CA  . MET A 1 231 ? 149.315 107.719 125.196 1.00 10.30 ? 259 MET A CA  1 
ATOM   1812 C C   . MET A 1 231 ? 149.538 106.217 125.109 1.00 10.30 ? 259 MET A C   1 
ATOM   1813 O O   . MET A 1 231 ? 149.900 105.724 124.036 1.00 10.30 ? 259 MET A O   1 
ATOM   1814 C CB  . MET A 1 231 ? 150.555 108.461 124.696 1.00 10.30 ? 259 MET A CB  1 
ATOM   1815 C CG  . MET A 1 231 ? 150.276 109.906 124.319 1.00 10.30 ? 259 MET A CG  1 
ATOM   1816 S SD  . MET A 1 231 ? 151.358 110.533 123.024 1.00 10.30 ? 259 MET A SD  1 
ATOM   1817 C CE  . MET A 1 231 ? 150.837 112.244 122.963 1.00 10.30 ? 259 MET A CE  1 
ATOM   1818 N N   . SER A 1 232 ? 149.340 105.481 126.205 1.00 9.29  ? 260 SER A N   1 
ATOM   1819 C CA  . SER A 1 232 ? 149.394 104.026 126.143 1.00 9.29  ? 260 SER A CA  1 
ATOM   1820 C C   . SER A 1 232 ? 148.227 103.439 125.364 1.00 9.29  ? 260 SER A C   1 
ATOM   1821 O O   . SER A 1 232 ? 148.335 102.315 124.866 1.00 9.29  ? 260 SER A O   1 
ATOM   1822 C CB  . SER A 1 232 ? 149.419 103.433 127.552 1.00 9.29  ? 260 SER A CB  1 
ATOM   1823 O OG  . SER A 1 232 ? 149.692 102.044 127.509 1.00 9.29  ? 260 SER A OG  1 
ATOM   1824 N N   . LEU A 1 233 ? 147.124 104.166 125.253 1.00 8.35  ? 261 LEU A N   1 
ATOM   1825 C CA  . LEU A 1 233 ? 145.969 103.682 124.508 1.00 8.35  ? 261 LEU A CA  1 
ATOM   1826 C C   . LEU A 1 233 ? 146.290 103.703 123.020 1.00 8.35  ? 261 LEU A C   1 
ATOM   1827 O O   . LEU A 1 233 ? 146.573 104.777 122.474 1.00 8.35  ? 261 LEU A O   1 
ATOM   1828 C CB  . LEU A 1 233 ? 144.748 104.550 124.806 1.00 8.35  ? 261 LEU A CB  1 
ATOM   1829 C CG  . LEU A 1 233 ? 143.972 104.323 126.106 1.00 8.35  ? 261 LEU A CG  1 
ATOM   1830 C CD1 . LEU A 1 233 ? 144.751 104.816 127.306 1.00 8.35  ? 261 LEU A CD1 1 
ATOM   1831 C CD2 . LEU A 1 233 ? 142.628 105.019 126.045 1.00 8.35  ? 261 LEU A CD2 1 
ATOM   1832 N N   . PRO A 1 234 ? 146.267 102.562 122.328 1.00 9.58  ? 262 PRO A N   1 
ATOM   1833 C CA  . PRO A 1 234 ? 146.623 102.570 120.900 1.00 9.58  ? 262 PRO A CA  1 
ATOM   1834 C C   . PRO A 1 234 ? 145.654 103.351 120.029 1.00 9.58  ? 262 PRO A C   1 
ATOM   1835 O O   . PRO A 1 234 ? 146.030 103.768 118.927 1.00 9.58  ? 262 PRO A O   1 
ATOM   1836 C CB  . PRO A 1 234 ? 146.643 101.079 120.534 1.00 9.58  ? 262 PRO A CB  1 
ATOM   1837 C CG  . PRO A 1 234 ? 145.801 100.415 121.570 1.00 9.58  ? 262 PRO A CG  1 
ATOM   1838 C CD  . PRO A 1 234 ? 146.001 101.203 122.829 1.00 9.58  ? 262 PRO A CD  1 
ATOM   1839 N N   . GLU A 1 235 ? 144.418 103.563 120.482 1.00 9.78  ? 263 GLU A N   1 
ATOM   1840 C CA  . GLU A 1 235 ? 143.421 104.292 119.709 1.00 9.78  ? 263 GLU A CA  1 
ATOM   1841 C C   . GLU A 1 235 ? 143.310 105.751 120.138 1.00 9.78  ? 263 GLU A C   1 
ATOM   1842 O O   . GLU A 1 235 ? 142.248 106.365 119.994 1.00 9.78  ? 263 GLU A O   1 
ATOM   1843 C CB  . GLU A 1 235 ? 142.063 103.595 119.801 1.00 9.78  ? 263 GLU A CB  1 
ATOM   1844 C CG  . GLU A 1 235 ? 141.492 103.492 121.203 1.00 9.78  ? 263 GLU A CG  1 
ATOM   1845 C CD  . GLU A 1 235 ? 141.823 102.178 121.877 1.00 9.78  ? 263 GLU A CD  1 
ATOM   1846 O OE1 . GLU A 1 235 ? 143.023 101.891 122.054 1.00 9.78  ? 263 GLU A OE1 1 
ATOM   1847 O OE2 . GLU A 1 235 ? 140.886 101.430 122.225 1.00 9.78  ? 263 GLU A OE2 1 
ATOM   1848 N N   . LEU A 1 236 ? 144.393 106.314 120.668 1.00 7.92  ? 264 LEU A N   1 
ATOM   1849 C CA  . LEU A 1 236 ? 144.419 107.712 121.067 1.00 7.92  ? 264 LEU A CA  1 
ATOM   1850 C C   . LEU A 1 236 ? 145.728 108.397 120.703 1.00 7.92  ? 264 LEU A C   1 
ATOM   1851 O O   . LEU A 1 236 ? 145.848 109.608 120.900 1.00 7.92  ? 264 LEU A O   1 
ATOM   1852 C CB  . LEU A 1 236 ? 144.157 107.818 122.579 1.00 7.92  ? 264 LEU A CB  1 
ATOM   1853 C CG  . LEU A 1 236 ? 143.924 109.123 123.334 1.00 7.92  ? 264 LEU A CG  1 
ATOM   1854 C CD1 . LEU A 1 236 ? 143.006 108.826 124.490 1.00 7.92  ? 264 LEU A CD1 1 
ATOM   1855 C CD2 . LEU A 1 236 ? 145.226 109.657 123.869 1.00 7.92  ? 264 LEU A CD2 1 
ATOM   1856 N N   . GLN A 1 237 ? 146.695 107.671 120.142 1.00 11.34 ? 265 GLN A N   1 
ATOM   1857 C CA  . GLN A 1 237 ? 147.988 108.247 119.799 1.00 11.34 ? 265 GLN A CA  1 
ATOM   1858 C C   . GLN A 1 237 ? 147.930 109.175 118.593 1.00 11.34 ? 265 GLN A C   1 
ATOM   1859 O O   . GLN A 1 237 ? 148.923 109.855 118.314 1.00 11.34 ? 265 GLN A O   1 
ATOM   1860 C CB  . GLN A 1 237 ? 148.996 107.128 119.535 1.00 11.34 ? 265 GLN A CB  1 
ATOM   1861 C CG  . GLN A 1 237 ? 150.428 107.482 119.887 1.00 11.34 ? 265 GLN A CG  1 
ATOM   1862 C CD  . GLN A 1 237 ? 151.344 106.275 119.872 1.00 11.34 ? 265 GLN A CD  1 
ATOM   1863 O OE1 . GLN A 1 237 ? 150.885 105.133 119.856 1.00 11.34 ? 265 GLN A OE1 1 
ATOM   1864 N NE2 . GLN A 1 237 ? 152.649 106.521 119.875 1.00 11.34 ? 265 GLN A NE2 1 
ATOM   1865 N N   . GLN A 1 238 ? 146.812 109.222 117.870 1.00 9.60  ? 266 GLN A N   1 
ATOM   1866 C CA  . GLN A 1 238 ? 146.687 110.060 116.684 1.00 9.60  ? 266 GLN A CA  1 
ATOM   1867 C C   . GLN A 1 238 ? 145.774 111.262 116.897 1.00 9.60  ? 266 GLN A C   1 
ATOM   1868 O O   . GLN A 1 238 ? 145.447 111.955 115.930 1.00 9.60  ? 266 GLN A O   1 
ATOM   1869 C CB  . GLN A 1 238 ? 146.191 109.229 115.499 1.00 9.60  ? 266 GLN A CB  1 
ATOM   1870 C CG  . GLN A 1 238 ? 145.111 108.221 115.850 1.00 9.60  ? 266 GLN A CG  1 
ATOM   1871 C CD  . GLN A 1 238 ? 143.723 108.823 115.818 1.00 9.60  ? 266 GLN A CD  1 
ATOM   1872 O OE1 . GLN A 1 238 ? 143.509 109.880 115.229 1.00 9.60  ? 266 GLN A OE1 1 
ATOM   1873 N NE2 . GLN A 1 238 ? 142.770 108.149 116.450 1.00 9.60  ? 266 GLN A NE2 1 
ATOM   1874 N N   . ASN A 1 239 ? 145.350 111.522 118.123 1.00 6.94  ? 267 ASN A N   1 
ATOM   1875 C CA  . ASN A 1 239 ? 144.570 112.719 118.404 1.00 6.94  ? 267 ASN A CA  1 
ATOM   1876 C C   . ASN A 1 239 ? 145.497 113.928 118.400 1.00 6.94  ? 267 ASN A C   1 
ATOM   1877 O O   . ASN A 1 239 ? 146.498 113.926 119.127 1.00 6.94  ? 267 ASN A O   1 
ATOM   1878 C CB  . ASN A 1 239 ? 143.864 112.589 119.747 1.00 6.94  ? 267 ASN A CB  1 
ATOM   1879 C CG  . ASN A 1 239 ? 142.541 113.314 119.781 1.00 6.94  ? 267 ASN A CG  1 
ATOM   1880 O OD1 . ASN A 1 239 ? 142.231 114.096 118.891 1.00 6.94  ? 267 ASN A OD1 1 
ATOM   1881 N ND2 . ASN A 1 239 ? 141.751 113.056 120.807 1.00 6.94  ? 267 ASN A ND2 1 
ATOM   1882 N N   . PRO A 1 240 ? 145.225 114.965 117.594 1.00 2.72  ? 268 PRO A N   1 
ATOM   1883 C CA  . PRO A 1 240 ? 146.125 116.128 117.551 1.00 2.72  ? 268 PRO A CA  1 
ATOM   1884 C C   . PRO A 1 240 ? 146.228 116.871 118.873 1.00 2.72  ? 268 PRO A C   1 
ATOM   1885 O O   . PRO A 1 240 ? 147.329 117.072 119.395 1.00 2.72  ? 268 PRO A O   1 
ATOM   1886 C CB  . PRO A 1 240 ? 145.493 117.013 116.470 1.00 2.72  ? 268 PRO A CB  1 
ATOM   1887 C CG  . PRO A 1 240 ? 144.703 116.079 115.631 1.00 2.72  ? 268 PRO A CG  1 
ATOM   1888 C CD  . PRO A 1 240 ? 144.170 115.049 116.573 1.00 2.72  ? 268 PRO A CD  1 
ATOM   1889 N N   . LEU A 1 241 ? 145.091 117.294 119.417 1.00 2.20  ? 269 LEU A N   1 
ATOM   1890 C CA  . LEU A 1 241 ? 145.063 118.032 120.679 1.00 2.20  ? 269 LEU A CA  1 
ATOM   1891 C C   . LEU A 1 241 ? 144.722 117.100 121.845 1.00 2.20  ? 269 LEU A C   1 
ATOM   1892 O O   . LEU A 1 241 ? 143.698 117.216 122.516 1.00 2.20  ? 269 LEU A O   1 
ATOM   1893 C CB  . LEU A 1 241 ? 144.107 119.220 120.576 1.00 2.20  ? 269 LEU A CB  1 
ATOM   1894 C CG  . LEU A 1 241 ? 142.592 119.054 120.543 1.00 2.20  ? 269 LEU A CG  1 
ATOM   1895 C CD1 . LEU A 1 241 ? 141.937 120.377 120.818 1.00 2.20  ? 269 LEU A CD1 1 
ATOM   1896 C CD2 . LEU A 1 241 ? 142.173 118.550 119.186 1.00 2.20  ? 269 LEU A CD2 1 
ATOM   1897 N N   . VAL A 1 242 ? 145.633 116.164 122.094 1.00 3.50  ? 270 VAL A N   1 
ATOM   1898 C CA  . VAL A 1 242 ? 145.533 115.353 123.301 1.00 3.50  ? 270 VAL A CA  1 
ATOM   1899 C C   . VAL A 1 242 ? 146.342 115.957 124.444 1.00 3.50  ? 270 VAL A C   1 
ATOM   1900 O O   . VAL A 1 242 ? 145.905 115.914 125.597 1.00 3.50  ? 270 VAL A O   1 
ATOM   1901 C CB  . VAL A 1 242 ? 145.964 113.902 123.030 1.00 3.50  ? 270 VAL A CB  1 
ATOM   1902 C CG1 . VAL A 1 242 ? 147.367 113.854 122.439 1.00 3.50  ? 270 VAL A CG1 1 
ATOM   1903 C CG2 . VAL A 1 242 ? 145.901 113.090 124.310 1.00 3.50  ? 270 VAL A CG2 1 
ATOM   1904 N N   . GLN A 1 243 ? 147.508 116.533 124.147 1.00 4.61  ? 271 GLN A N   1 
ATOM   1905 C CA  . GLN A 1 243 ? 148.326 117.133 125.194 1.00 4.61  ? 271 GLN A CA  1 
ATOM   1906 C C   . GLN A 1 243 ? 147.584 118.269 125.886 1.00 4.61  ? 271 GLN A C   1 
ATOM   1907 O O   . GLN A 1 243 ? 147.710 118.459 127.102 1.00 4.61  ? 271 GLN A O   1 
ATOM   1908 C CB  . GLN A 1 243 ? 149.640 117.634 124.595 1.00 4.61  ? 271 GLN A CB  1 
ATOM   1909 C CG  . GLN A 1 243 ? 150.486 118.486 125.518 1.00 4.61  ? 271 GLN A CG  1 
ATOM   1910 C CD  . GLN A 1 243 ? 151.059 117.699 126.673 1.00 4.61  ? 271 GLN A CD  1 
ATOM   1911 O OE1 . GLN A 1 243 ? 151.382 116.520 126.535 1.00 4.61  ? 271 GLN A OE1 1 
ATOM   1912 N NE2 . GLN A 1 243 ? 151.185 118.347 127.825 1.00 4.61  ? 271 GLN A NE2 1 
ATOM   1913 N N   . ARG A 1 244 ? 146.783 119.021 125.131 1.00 3.54  ? 272 ARG A N   1 
ATOM   1914 C CA  . ARG A 1 244 ? 146.116 120.182 125.702 1.00 3.54  ? 272 ARG A CA  1 
ATOM   1915 C C   . ARG A 1 244 ? 145.082 119.781 126.747 1.00 3.54  ? 272 ARG A C   1 
ATOM   1916 O O   . ARG A 1 244 ? 144.989 120.420 127.797 1.00 3.54  ? 272 ARG A O   1 
ATOM   1917 C CB  . ARG A 1 244 ? 145.479 121.010 124.593 1.00 3.54  ? 272 ARG A CB  1 
ATOM   1918 C CG  . ARG A 1 244 ? 146.465 121.900 123.861 1.00 3.54  ? 272 ARG A CG  1 
ATOM   1919 C CD  . ARG A 1 244 ? 147.129 122.903 124.790 1.00 3.54  ? 272 ARG A CD  1 
ATOM   1920 N NE  . ARG A 1 244 ? 146.151 123.640 125.583 1.00 3.54  ? 272 ARG A NE  1 
ATOM   1921 C CZ  . ARG A 1 244 ? 146.431 124.276 126.714 1.00 3.54  ? 272 ARG A CZ  1 
ATOM   1922 N NH1 . ARG A 1 244 ? 147.665 124.260 127.193 1.00 3.54  ? 272 ARG A NH1 1 
ATOM   1923 N NH2 . ARG A 1 244 ? 145.474 124.921 127.370 1.00 3.54  ? 272 ARG A NH2 1 
ATOM   1924 N N   . VAL A 1 245 ? 144.308 118.723 126.501 1.00 3.14  ? 273 VAL A N   1 
ATOM   1925 C CA  . VAL A 1 245 ? 143.287 118.339 127.474 1.00 3.14  ? 273 VAL A CA  1 
ATOM   1926 C C   . VAL A 1 245 ? 143.936 117.868 128.767 1.00 3.14  ? 273 VAL A C   1 
ATOM   1927 O O   . VAL A 1 245 ? 143.439 118.142 129.866 1.00 3.14  ? 273 VAL A O   1 
ATOM   1928 C CB  . VAL A 1 245 ? 142.351 117.268 126.895 1.00 3.14  ? 273 VAL A CB  1 
ATOM   1929 C CG1 . VAL A 1 245 ? 141.263 116.961 127.892 1.00 3.14  ? 273 VAL A CG1 1 
ATOM   1930 C CG2 . VAL A 1 245 ? 141.753 117.744 125.595 1.00 3.14  ? 273 VAL A CG2 1 
ATOM   1931 N N   . ILE A 1 246 ? 145.063 117.162 128.660 1.00 3.18  ? 274 ILE A N   1 
ATOM   1932 C CA  . ILE A 1 246 ? 145.841 116.823 129.846 1.00 3.18  ? 274 ILE A CA  1 
ATOM   1933 C C   . ILE A 1 246 ? 146.295 118.090 130.558 1.00 3.18  ? 274 ILE A C   1 
ATOM   1934 O O   . ILE A 1 246 ? 146.286 118.162 131.792 1.00 3.18  ? 274 ILE A O   1 
ATOM   1935 C CB  . ILE A 1 246 ? 147.033 115.931 129.464 1.00 3.18  ? 274 ILE A CB  1 
ATOM   1936 C CG1 . ILE A 1 246 ? 146.544 114.613 128.880 1.00 3.18  ? 274 ILE A CG1 1 
ATOM   1937 C CG2 . ILE A 1 246 ? 147.889 115.658 130.666 1.00 3.18  ? 274 ILE A CG2 1 
ATOM   1938 C CD1 . ILE A 1 246 ? 147.621 113.838 128.156 1.00 3.18  ? 274 ILE A CD1 1 
ATOM   1939 N N   . ASP A 1 247 ? 146.693 119.112 129.796 1.00 2.52  ? 275 ASP A N   1 
ATOM   1940 C CA  . ASP A 1 247 ? 147.167 120.341 130.421 1.00 2.52  ? 275 ASP A CA  1 
ATOM   1941 C C   . ASP A 1 247 ? 146.056 121.106 131.133 1.00 2.52  ? 275 ASP A C   1 
ATOM   1942 O O   . ASP A 1 247 ? 146.331 121.792 132.120 1.00 2.52  ? 275 ASP A O   1 
ATOM   1943 C CB  . ASP A 1 247 ? 147.852 121.223 129.388 1.00 2.52  ? 275 ASP A CB  1 
ATOM   1944 C CG  . ASP A 1 247 ? 149.307 120.868 129.215 1.00 2.52  ? 275 ASP A CG  1 
ATOM   1945 O OD1 . ASP A 1 247 ? 150.090 121.727 128.766 1.00 2.52  ? 275 ASP A OD1 1 
ATOM   1946 O OD2 . ASP A 1 247 ? 149.674 119.725 129.548 1.00 2.52  ? 275 ASP A OD2 1 
ATOM   1947 N N   . ILE A 1 248 ? 144.811 121.037 130.656 1.00 3.18  ? 276 ILE A N   1 
ATOM   1948 C CA  . ILE A 1 248 ? 143.722 121.583 131.475 1.00 3.18  ? 276 ILE A CA  1 
ATOM   1949 C C   . ILE A 1 248 ? 143.473 120.706 132.700 1.00 3.18  ? 276 ILE A C   1 
ATOM   1950 O O   . ILE A 1 248 ? 143.215 121.216 133.798 1.00 3.18  ? 276 ILE A O   1 
ATOM   1951 C CB  . ILE A 1 248 ? 142.414 121.825 130.690 1.00 3.18  ? 276 ILE A CB  1 
ATOM   1952 C CG1 . ILE A 1 248 ? 142.560 122.882 129.590 1.00 3.18  ? 276 ILE A CG1 1 
ATOM   1953 C CG2 . ILE A 1 248 ? 141.305 122.255 131.633 1.00 3.18  ? 276 ILE A CG2 1 
ATOM   1954 C CD1 . ILE A 1 248 ? 142.976 122.401 128.272 1.00 3.18  ? 276 ILE A CD1 1 
ATOM   1955 N N   . PHE A 1 249 ? 143.531 119.381 132.541 1.00 2.95  ? 277 PHE A N   1 
ATOM   1956 C CA  . PHE A 1 249 ? 143.408 118.508 133.707 1.00 2.95  ? 277 PHE A CA  1 
ATOM   1957 C C   . PHE A 1 249 ? 144.497 118.803 134.729 1.00 2.95  ? 277 PHE A C   1 
ATOM   1958 O O   . PHE A 1 249 ? 144.222 118.930 135.926 1.00 2.95  ? 277 PHE A O   1 
ATOM   1959 C CB  . PHE A 1 249 ? 143.455 117.033 133.297 1.00 2.95  ? 277 PHE A CB  1 
ATOM   1960 C CG  . PHE A 1 249 ? 142.143 116.485 132.806 1.00 2.95  ? 277 PHE A CG  1 
ATOM   1961 C CD1 . PHE A 1 249 ? 140.985 117.231 132.896 1.00 2.95  ? 277 PHE A CD1 1 
ATOM   1962 C CD2 . PHE A 1 249 ? 142.064 115.196 132.309 1.00 2.95  ? 277 PHE A CD2 1 
ATOM   1963 C CE1 . PHE A 1 249 ? 139.782 116.715 132.464 1.00 2.95  ? 277 PHE A CE1 1 
ATOM   1964 C CE2 . PHE A 1 249 ? 140.866 114.676 131.881 1.00 2.95  ? 277 PHE A CE2 1 
ATOM   1965 C CZ  . PHE A 1 249 ? 139.723 115.435 131.960 1.00 2.95  ? 277 PHE A CZ  1 
ATOM   1966 N N   . ASP A 1 250 ? 145.733 118.945 134.270 1.00 3.66  ? 278 ASP A N   1 
ATOM   1967 C CA  . ASP A 1 250 ? 146.881 119.147 135.149 1.00 3.66  ? 278 ASP A CA  1 
ATOM   1968 C C   . ASP A 1 250 ? 146.814 120.568 135.699 1.00 3.66  ? 278 ASP A C   1 
ATOM   1969 O O   . ASP A 1 250 ? 147.337 121.507 135.098 1.00 3.66  ? 278 ASP A O   1 
ATOM   1970 C CB  . ASP A 1 250 ? 148.158 118.890 134.355 1.00 3.66  ? 278 ASP A CB  1 
ATOM   1971 C CG  . ASP A 1 250 ? 149.424 119.174 135.132 1.00 3.66  ? 278 ASP A CG  1 
ATOM   1972 O OD1 . ASP A 1 250 ? 150.490 118.707 134.683 1.00 3.66  ? 278 ASP A OD1 1 
ATOM   1973 O OD2 . ASP A 1 250 ? 149.381 119.841 136.181 1.00 3.66  ? 278 ASP A OD2 1 
ATOM   1974 N N   . THR A 1 251 ? 146.193 120.724 136.867 1.00 5.05  ? 279 THR A N   1 
ATOM   1975 C CA  . THR A 1 251 ? 145.920 122.042 137.428 1.00 5.05  ? 279 THR A CA  1 
ATOM   1976 C C   . THR A 1 251 ? 147.104 122.630 138.190 1.00 5.05  ? 279 THR A C   1 
ATOM   1977 O O   . THR A 1 251 ? 147.428 123.808 138.010 1.00 5.05  ? 279 THR A O   1 
ATOM   1978 C CB  . THR A 1 251 ? 144.703 121.976 138.354 1.00 5.05  ? 279 THR A CB  1 
ATOM   1979 O OG1 . THR A 1 251 ? 143.553 121.567 137.605 1.00 5.05  ? 279 THR A OG1 1 
ATOM   1980 C CG2 . THR A 1 251 ? 144.439 123.331 138.983 1.00 5.05  ? 279 THR A CG2 1 
ATOM   1981 N N   . ASP A 1 252 ? 147.760 121.845 139.038 1.00 6.34  ? 280 ASP A N   1 
ATOM   1982 C CA  . ASP A 1 252 ? 148.820 122.363 139.891 1.00 6.34  ? 280 ASP A CA  1 
ATOM   1983 C C   . ASP A 1 252 ? 150.195 122.316 139.239 1.00 6.34  ? 280 ASP A C   1 
ATOM   1984 O O   . ASP A 1 252 ? 151.182 122.668 139.891 1.00 6.34  ? 280 ASP A O   1 
ATOM   1985 C CB  . ASP A 1 252 ? 148.846 121.604 141.222 1.00 6.34  ? 280 ASP A CB  1 
ATOM   1986 C CG  . ASP A 1 252 ? 148.839 120.101 141.039 1.00 6.34  ? 280 ASP A CG  1 
ATOM   1987 O OD1 . ASP A 1 252 ? 148.949 119.634 139.887 1.00 6.34  ? 280 ASP A OD1 1 
ATOM   1988 O OD2 . ASP A 1 252 ? 148.722 119.382 142.053 1.00 6.34  ? 280 ASP A OD2 1 
ATOM   1989 N N   . GLY A 1 253 ? 150.291 121.887 137.985 1.00 5.28  ? 281 GLY A N   1 
ATOM   1990 C CA  . GLY A 1 253 ? 151.556 121.918 137.280 1.00 5.28  ? 281 GLY A CA  1 
ATOM   1991 C C   . GLY A 1 253 ? 152.555 120.868 137.700 1.00 5.28  ? 281 GLY A C   1 
ATOM   1992 O O   . GLY A 1 253 ? 153.716 120.943 137.285 1.00 5.28  ? 281 GLY A O   1 
ATOM   1993 N N   . ASN A 1 254 ? 152.141 119.887 138.504 1.00 8.28  ? 282 ASN A N   1 
ATOM   1994 C CA  . ASN A 1 254 ? 153.066 118.870 138.990 1.00 8.28  ? 282 ASN A CA  1 
ATOM   1995 C C   . ASN A 1 254 ? 153.626 118.011 137.866 1.00 8.28  ? 282 ASN A C   1 
ATOM   1996 O O   . ASN A 1 254 ? 154.689 117.404 138.033 1.00 8.28  ? 282 ASN A O   1 
ATOM   1997 C CB  . ASN A 1 254 ? 152.369 117.989 140.029 1.00 8.28  ? 282 ASN A CB  1 
ATOM   1998 C CG  . ASN A 1 254 ? 151.237 117.168 139.437 1.00 8.28  ? 282 ASN A CG  1 
ATOM   1999 O OD1 . ASN A 1 254 ? 151.463 116.273 138.627 1.00 8.28  ? 282 ASN A OD1 1 
ATOM   2000 N ND2 . ASN A 1 254 ? 150.009 117.475 139.838 1.00 8.28  ? 282 ASN A ND2 1 
ATOM   2001 N N   . GLY A 1 255 ? 152.936 117.942 136.731 1.00 10.30 ? 283 GLY A N   1 
ATOM   2002 C CA  . GLY A 1 255 ? 153.351 117.128 135.607 1.00 10.30 ? 283 GLY A CA  1 
ATOM   2003 C C   . GLY A 1 255 ? 152.498 115.902 135.370 1.00 10.30 ? 283 GLY A C   1 
ATOM   2004 O O   . GLY A 1 255 ? 152.672 115.241 134.339 1.00 10.30 ? 283 GLY A O   1 
ATOM   2005 N N   . GLU A 1 256 ? 151.587 115.572 136.283 1.00 10.90 ? 284 GLU A N   1 
ATOM   2006 C CA  . GLU A 1 256 ? 150.748 114.391 136.148 1.00 10.90 ? 284 GLU A CA  1 
ATOM   2007 C C   . GLU A 1 256 ? 149.356 114.682 136.692 1.00 10.90 ? 284 GLU A C   1 
ATOM   2008 O O   . GLU A 1 256 ? 149.124 115.694 137.358 1.00 10.90 ? 284 GLU A O   1 
ATOM   2009 C CB  . GLU A 1 256 ? 151.354 113.181 136.870 1.00 10.90 ? 284 GLU A CB  1 
ATOM   2010 C CG  . GLU A 1 256 ? 152.557 112.573 136.169 1.00 10.90 ? 284 GLU A CG  1 
ATOM   2011 C CD  . GLU A 1 256 ? 153.865 113.207 136.595 1.00 10.90 ? 284 GLU A CD  1 
ATOM   2012 O OE1 . GLU A 1 256 ? 153.834 114.123 137.442 1.00 10.90 ? 284 GLU A OE1 1 
ATOM   2013 O OE2 . GLU A 1 256 ? 154.924 112.788 136.082 1.00 10.90 ? 284 GLU A OE2 1 
ATOM   2014 N N   . VAL A 1 257 ? 148.427 113.777 136.396 1.00 8.64  ? 285 VAL A N   1 
ATOM   2015 C CA  . VAL A 1 257 ? 147.039 113.891 136.829 1.00 8.64  ? 285 VAL A CA  1 
ATOM   2016 C C   . VAL A 1 257 ? 146.797 112.894 137.954 1.00 8.64  ? 285 VAL A C   1 
ATOM   2017 O O   . VAL A 1 257 ? 147.234 111.739 137.875 1.00 8.64  ? 285 VAL A O   1 
ATOM   2018 C CB  . VAL A 1 257 ? 146.070 113.650 135.659 1.00 8.64  ? 285 VAL A CB  1 
ATOM   2019 C CG1 . VAL A 1 257 ? 144.631 113.807 136.114 1.00 8.64  ? 285 VAL A CG1 1 
ATOM   2020 C CG2 . VAL A 1 257 ? 146.373 114.601 134.524 1.00 8.64  ? 285 VAL A CG2 1 
ATOM   2021 N N   . ASP A 1 258 ? 146.117 113.340 139.007 1.00 6.67  ? 286 ASP A N   1 
ATOM   2022 C CA  . ASP A 1 258 ? 145.743 112.497 140.132 1.00 6.67  ? 286 ASP A CA  1 
ATOM   2023 C C   . ASP A 1 258 ? 144.229 112.496 140.295 1.00 6.67  ? 286 ASP A C   1 
ATOM   2024 O O   . ASP A 1 258 ? 143.517 113.330 139.732 1.00 6.67  ? 286 ASP A O   1 
ATOM   2025 C CB  . ASP A 1 258 ? 146.418 112.967 141.423 1.00 6.67  ? 286 ASP A CB  1 
ATOM   2026 C CG  . ASP A 1 258 ? 147.900 113.215 141.246 1.00 6.67  ? 286 ASP A CG  1 
ATOM   2027 O OD1 . ASP A 1 258 ? 148.521 112.530 140.407 1.00 6.67  ? 286 ASP A OD1 1 
ATOM   2028 O OD2 . ASP A 1 258 ? 148.444 114.092 141.949 1.00 6.67  ? 286 ASP A OD2 1 
ATOM   2029 N N   . PHE A 1 259 ? 143.739 111.550 141.098 1.00 4.29  ? 287 PHE A N   1 
ATOM   2030 C CA  . PHE A 1 259 ? 142.301 111.351 141.233 1.00 4.29  ? 287 PHE A CA  1 
ATOM   2031 C C   . PHE A 1 259 ? 141.592 112.550 141.848 1.00 4.29  ? 287 PHE A C   1 
ATOM   2032 O O   . PHE A 1 259 ? 140.363 112.635 141.768 1.00 4.29  ? 287 PHE A O   1 
ATOM   2033 C CB  . PHE A 1 259 ? 142.021 110.104 142.072 1.00 4.29  ? 287 PHE A CB  1 
ATOM   2034 C CG  . PHE A 1 259 ? 140.668 109.502 141.828 1.00 4.29  ? 287 PHE A CG  1 
ATOM   2035 C CD1 . PHE A 1 259 ? 140.373 108.894 140.622 1.00 4.29  ? 287 PHE A CD1 1 
ATOM   2036 C CD2 . PHE A 1 259 ? 139.689 109.551 142.804 1.00 4.29  ? 287 PHE A CD2 1 
ATOM   2037 C CE1 . PHE A 1 259 ? 139.128 108.343 140.397 1.00 4.29  ? 287 PHE A CE1 1 
ATOM   2038 C CE2 . PHE A 1 259 ? 138.444 109.003 142.583 1.00 4.29  ? 287 PHE A CE2 1 
ATOM   2039 C CZ  . PHE A 1 259 ? 138.164 108.398 141.378 1.00 4.29  ? 287 PHE A CZ  1 
ATOM   2040 N N   . LYS A 1 260 ? 142.326 113.469 142.472 1.00 3.71  ? 288 LYS A N   1 
ATOM   2041 C CA  . LYS A 1 260 ? 141.681 114.652 143.029 1.00 3.71  ? 288 LYS A CA  1 
ATOM   2042 C C   . LYS A 1 260 ? 141.238 115.611 141.935 1.00 3.71  ? 288 LYS A C   1 
ATOM   2043 O O   . LYS A 1 260 ? 140.263 116.350 142.115 1.00 3.71  ? 288 LYS A O   1 
ATOM   2044 C CB  . LYS A 1 260 ? 142.625 115.357 144.003 1.00 3.71  ? 288 LYS A CB  1 
ATOM   2045 N N   . GLU A 1 261 ? 141.938 115.614 140.803 1.00 4.00  ? 289 GLU A N   1 
ATOM   2046 C CA  . GLU A 1 261 ? 141.660 116.518 139.695 1.00 4.00  ? 289 GLU A CA  1 
ATOM   2047 C C   . GLU A 1 261 ? 141.134 115.805 138.456 1.00 4.00  ? 289 GLU A C   1 
ATOM   2048 O O   . GLU A 1 261 ? 140.441 116.427 137.645 1.00 4.00  ? 289 GLU A O   1 
ATOM   2049 C CB  . GLU A 1 261 ? 142.928 117.316 139.369 1.00 4.00  ? 289 GLU A CB  1 
ATOM   2050 C CG  . GLU A 1 261 ? 144.119 116.465 138.963 1.00 4.00  ? 289 GLU A CG  1 
ATOM   2051 C CD  . GLU A 1 261 ? 145.408 117.263 138.904 1.00 4.00  ? 289 GLU A CD  1 
ATOM   2052 O OE1 . GLU A 1 261 ? 145.372 118.470 139.215 1.00 4.00  ? 289 GLU A OE1 1 
ATOM   2053 O OE2 . GLU A 1 261 ? 146.460 116.684 138.564 1.00 4.00  ? 289 GLU A OE2 1 
ATOM   2054 N N   . PHE A 1 262 ? 141.417 114.506 138.323 1.00 3.32  ? 290 PHE A N   1 
ATOM   2055 C CA  . PHE A 1 262 ? 140.805 113.674 137.289 1.00 3.32  ? 290 PHE A CA  1 
ATOM   2056 C C   . PHE A 1 262 ? 139.289 113.823 137.281 1.00 3.32  ? 290 PHE A C   1 
ATOM   2057 O O   . PHE A 1 262 ? 138.698 114.280 136.295 1.00 3.32  ? 290 PHE A O   1 
ATOM   2058 C CB  . PHE A 1 262 ? 141.191 112.215 137.537 1.00 3.32  ? 290 PHE A CB  1 
ATOM   2059 C CG  . PHE A 1 262 ? 140.844 111.275 136.418 1.00 3.32  ? 290 PHE A CG  1 
ATOM   2060 C CD1 . PHE A 1 262 ? 141.705 111.087 135.359 1.00 3.32  ? 290 PHE A CD1 1 
ATOM   2061 C CD2 . PHE A 1 262 ? 139.663 110.558 136.444 1.00 3.32  ? 290 PHE A CD2 1 
ATOM   2062 C CE1 . PHE A 1 262 ? 141.389 110.208 134.343 1.00 3.32  ? 290 PHE A CE1 1 
ATOM   2063 C CE2 . PHE A 1 262 ? 139.344 109.681 135.427 1.00 3.32  ? 290 PHE A CE2 1 
ATOM   2064 C CZ  . PHE A 1 262 ? 140.207 109.507 134.379 1.00 3.32  ? 290 PHE A CZ  1 
ATOM   2065 N N   . ILE A 1 263 ? 138.641 113.437 138.382 1.00 2.91  ? 291 ILE A N   1 
ATOM   2066 C CA  . ILE A 1 263 ? 137.186 113.423 138.432 1.00 2.91  ? 291 ILE A CA  1 
ATOM   2067 C C   . ILE A 1 263 ? 136.604 114.818 138.564 1.00 2.91  ? 291 ILE A C   1 
ATOM   2068 O O   . ILE A 1 263 ? 135.414 115.014 138.296 1.00 2.91  ? 291 ILE A O   1 
ATOM   2069 C CB  . ILE A 1 263 ? 136.696 112.535 139.585 1.00 2.91  ? 291 ILE A CB  1 
ATOM   2070 C CG1 . ILE A 1 263 ? 137.179 113.092 140.923 1.00 2.91  ? 291 ILE A CG1 1 
ATOM   2071 C CG2 . ILE A 1 263 ? 137.185 111.118 139.395 1.00 2.91  ? 291 ILE A CG2 1 
ATOM   2072 C CD1 . ILE A 1 263 ? 136.558 112.422 142.124 1.00 2.91  ? 291 ILE A CD1 1 
ATOM   2073 N N   . GLU A 1 264 ? 137.397 115.797 138.990 1.00 4.19  ? 292 GLU A N   1 
ATOM   2074 C CA  . GLU A 1 264 ? 136.904 117.166 138.998 1.00 4.19  ? 292 GLU A CA  1 
ATOM   2075 C C   . GLU A 1 264 ? 136.887 117.761 137.599 1.00 4.19  ? 292 GLU A C   1 
ATOM   2076 O O   . GLU A 1 264 ? 136.000 118.559 137.282 1.00 4.19  ? 292 GLU A O   1 
ATOM   2077 C CB  . GLU A 1 264 ? 137.747 118.033 139.932 1.00 4.19  ? 292 GLU A CB  1 
ATOM   2078 C CG  . GLU A 1 264 ? 137.149 119.403 140.205 1.00 4.19  ? 292 GLU A CG  1 
ATOM   2079 C CD  . GLU A 1 264 ? 137.482 119.924 141.587 1.00 4.19  ? 292 GLU A CD  1 
ATOM   2080 O OE1 . GLU A 1 264 ? 138.476 119.450 142.177 1.00 4.19  ? 292 GLU A OE1 1 
ATOM   2081 O OE2 . GLU A 1 264 ? 136.754 120.810 142.080 1.00 4.19  ? 292 GLU A OE2 1 
ATOM   2082 N N   . GLY A 1 265 ? 137.849 117.385 136.752 1.00 3.27  ? 293 GLY A N   1 
ATOM   2083 C CA  . GLY A 1 265 ? 137.851 117.872 135.385 1.00 3.27  ? 293 GLY A CA  1 
ATOM   2084 C C   . GLY A 1 265 ? 136.920 117.118 134.464 1.00 3.27  ? 293 GLY A C   1 
ATOM   2085 O O   . GLY A 1 265 ? 136.347 117.711 133.546 1.00 3.27  ? 293 GLY A O   1 
ATOM   2086 N N   . VAL A 1 266 ? 136.756 115.811 134.681 1.00 4.81  ? 294 VAL A N   1 
ATOM   2087 C CA  . VAL A 1 266 ? 135.818 115.055 133.858 1.00 4.81  ? 294 VAL A CA  1 
ATOM   2088 C C   . VAL A 1 266 ? 134.389 115.507 134.124 1.00 4.81  ? 294 VAL A C   1 
ATOM   2089 O O   . VAL A 1 266 ? 133.564 115.553 133.204 1.00 4.81  ? 294 VAL A O   1 
ATOM   2090 C CB  . VAL A 1 266 ? 135.996 113.545 134.088 1.00 4.81  ? 294 VAL A CB  1 
ATOM   2091 C CG1 . VAL A 1 266 ? 134.784 112.781 133.603 1.00 4.81  ? 294 VAL A CG1 1 
ATOM   2092 C CG2 . VAL A 1 266 ? 137.238 113.059 133.370 1.00 4.81  ? 294 VAL A CG2 1 
ATOM   2093 N N   . SER A 1 267 ? 134.074 115.871 135.368 1.00 4.15  ? 295 SER A N   1 
ATOM   2094 C CA  . SER A 1 267 ? 132.740 116.363 135.695 1.00 4.15  ? 295 SER A CA  1 
ATOM   2095 C C   . SER A 1 267 ? 132.403 117.666 134.987 1.00 4.15  ? 295 SER A C   1 
ATOM   2096 O O   . SER A 1 267 ? 131.230 118.050 134.964 1.00 4.15  ? 295 SER A O   1 
ATOM   2097 C CB  . SER A 1 267 ? 132.600 116.558 137.202 1.00 4.15  ? 295 SER A CB  1 
ATOM   2098 O OG  . SER A 1 267 ? 131.299 117.010 137.525 1.00 4.15  ? 295 SER A OG  1 
ATOM   2099 N N   . GLN A 1 268 ? 133.398 118.360 134.431 1.00 6.41  ? 296 GLN A N   1 
ATOM   2100 C CA  . GLN A 1 268 ? 133.119 119.548 133.632 1.00 6.41  ? 296 GLN A CA  1 
ATOM   2101 C C   . GLN A 1 268 ? 132.298 119.192 132.400 1.00 6.41  ? 296 GLN A C   1 
ATOM   2102 O O   . GLN A 1 268 ? 131.471 119.990 131.945 1.00 6.41  ? 296 GLN A O   1 
ATOM   2103 C CB  . GLN A 1 268 ? 134.430 120.222 133.234 1.00 6.41  ? 296 GLN A CB  1 
ATOM   2104 C CG  . GLN A 1 268 ? 134.377 121.734 133.179 1.00 6.41  ? 296 GLN A CG  1 
ATOM   2105 C CD  . GLN A 1 268 ? 135.751 122.360 133.309 1.00 6.41  ? 296 GLN A CD  1 
ATOM   2106 O OE1 . GLN A 1 268 ? 136.766 121.665 133.285 1.00 6.41  ? 296 GLN A OE1 1 
ATOM   2107 N NE2 . GLN A 1 268 ? 135.791 123.680 133.449 1.00 6.41  ? 296 GLN A NE2 1 
ATOM   2108 N N   . PHE A 1 269 ? 132.515 117.999 131.847 1.00 6.63  ? 297 PHE A N   1 
ATOM   2109 C CA  . PHE A 1 269 ? 131.751 117.511 130.699 1.00 6.63  ? 297 PHE A CA  1 
ATOM   2110 C C   . PHE A 1 269 ? 130.637 116.580 131.173 1.00 6.63  ? 297 PHE A C   1 
ATOM   2111 O O   . PHE A 1 269 ? 130.681 115.360 131.015 1.00 6.63  ? 297 PHE A O   1 
ATOM   2112 C CB  . PHE A 1 269 ? 132.674 116.820 129.707 1.00 6.63  ? 297 PHE A CB  1 
ATOM   2113 C CG  . PHE A 1 269 ? 133.759 117.700 129.200 1.00 6.63  ? 297 PHE A CG  1 
ATOM   2114 C CD1 . PHE A 1 269 ? 133.470 118.960 128.720 1.00 6.63  ? 297 PHE A CD1 1 
ATOM   2115 C CD2 . PHE A 1 269 ? 135.068 117.288 129.226 1.00 6.63  ? 297 PHE A CD2 1 
ATOM   2116 C CE1 . PHE A 1 269 ? 134.468 119.779 128.257 1.00 6.63  ? 297 PHE A CE1 1 
ATOM   2117 C CE2 . PHE A 1 269 ? 136.071 118.105 128.767 1.00 6.63  ? 297 PHE A CE2 1 
ATOM   2118 C CZ  . PHE A 1 269 ? 135.771 119.347 128.280 1.00 6.63  ? 297 PHE A CZ  1 
ATOM   2119 N N   . SER A 1 270 ? 129.616 117.191 131.761 1.00 7.57  ? 298 SER A N   1 
ATOM   2120 C CA  . SER A 1 270 ? 128.452 116.467 132.240 1.00 7.57  ? 298 SER A CA  1 
ATOM   2121 C C   . SER A 1 270 ? 127.191 117.173 131.771 1.00 7.57  ? 298 SER A C   1 
ATOM   2122 O O   . SER A 1 270 ? 127.191 118.377 131.504 1.00 7.57  ? 298 SER A O   1 
ATOM   2123 C CB  . SER A 1 270 ? 128.447 116.349 133.766 1.00 7.57  ? 298 SER A CB  1 
ATOM   2124 O OG  . SER A 1 270 ? 127.275 115.695 134.213 1.00 7.57  ? 298 SER A OG  1 
ATOM   2125 N N   . VAL A 1 271 ? 126.110 116.400 131.666 1.00 9.42  ? 299 VAL A N   1 
ATOM   2126 C CA  . VAL A 1 271 ? 124.824 116.972 131.280 1.00 9.42  ? 299 VAL A CA  1 
ATOM   2127 C C   . VAL A 1 271 ? 124.358 117.972 132.328 1.00 9.42  ? 299 VAL A C   1 
ATOM   2128 O O   . VAL A 1 271 ? 123.770 119.010 132.001 1.00 9.42  ? 299 VAL A O   1 
ATOM   2129 C CB  . VAL A 1 271 ? 123.788 115.855 131.059 1.00 9.42  ? 299 VAL A CB  1 
ATOM   2130 C CG1 . VAL A 1 271 ? 122.447 116.445 130.658 1.00 9.42  ? 299 VAL A CG1 1 
ATOM   2131 C CG2 . VAL A 1 271 ? 124.285 114.875 130.011 1.00 9.42  ? 299 VAL A CG2 1 
ATOM   2132 N N   . LYS A 1 272 ? 124.621 117.680 133.603 1.00 10.36 ? 300 LYS A N   1 
ATOM   2133 C CA  . LYS A 1 272 ? 124.234 118.588 134.676 1.00 10.36 ? 300 LYS A CA  1 
ATOM   2134 C C   . LYS A 1 272 ? 124.969 119.921 134.601 1.00 10.36 ? 300 LYS A C   1 
ATOM   2135 O O   . LYS A 1 272 ? 124.495 120.909 135.172 1.00 10.36 ? 300 LYS A O   1 
ATOM   2136 C CB  . LYS A 1 272 ? 124.483 117.928 136.033 1.00 10.36 ? 300 LYS A CB  1 
ATOM   2137 N N   . GLY A 1 273 ? 126.106 119.973 133.912 1.00 10.72 ? 301 GLY A N   1 
ATOM   2138 C CA  . GLY A 1 273 ? 126.833 121.217 133.789 1.00 10.72 ? 301 GLY A CA  1 
ATOM   2139 C C   . GLY A 1 273 ? 126.116 122.220 132.907 1.00 10.72 ? 301 GLY A C   1 
ATOM   2140 O O   . GLY A 1 273 ? 125.176 121.901 132.179 1.00 10.72 ? 301 GLY A O   1 
ATOM   2141 N N   . ASP A 1 274 ? 126.572 123.466 132.985 1.00 13.97 ? 302 ASP A N   1 
ATOM   2142 C CA  . ASP A 1 274 ? 125.973 124.562 132.244 1.00 13.97 ? 302 ASP A CA  1 
ATOM   2143 C C   . ASP A 1 274 ? 126.784 124.861 130.985 1.00 13.97 ? 302 ASP A C   1 
ATOM   2144 O O   . ASP A 1 274 ? 127.770 124.192 130.668 1.00 13.97 ? 302 ASP A O   1 
ATOM   2145 C CB  . ASP A 1 274 ? 125.860 125.804 133.130 1.00 13.97 ? 302 ASP A CB  1 
ATOM   2146 C CG  . ASP A 1 274 ? 124.807 125.657 134.207 1.00 13.97 ? 302 ASP A CG  1 
ATOM   2147 O OD1 . ASP A 1 274 ? 124.213 124.565 134.315 1.00 13.97 ? 302 ASP A OD1 1 
ATOM   2148 O OD2 . ASP A 1 274 ? 124.570 126.636 134.946 1.00 13.97 ? 302 ASP A OD2 1 
ATOM   2149 N N   . LYS A 1 275 ? 126.346 125.886 130.253 1.00 13.51 ? 303 LYS A N   1 
ATOM   2150 C CA  . LYS A 1 275 ? 127.077 126.326 129.070 1.00 13.51 ? 303 LYS A CA  1 
ATOM   2151 C C   . LYS A 1 275 ? 128.427 126.924 129.445 1.00 13.51 ? 303 LYS A C   1 
ATOM   2152 O O   . LYS A 1 275 ? 129.422 126.732 128.731 1.00 13.51 ? 303 LYS A O   1 
ATOM   2153 C CB  . LYS A 1 275 ? 126.233 127.338 128.295 1.00 13.51 ? 303 LYS A CB  1 
ATOM   2154 C CG  . LYS A 1 275 ? 127.011 128.201 127.317 1.00 13.51 ? 303 LYS A CG  1 
ATOM   2155 C CD  . LYS A 1 275 ? 126.074 128.943 126.381 1.00 13.51 ? 303 LYS A CD  1 
ATOM   2156 C CE  . LYS A 1 275 ? 126.813 129.482 125.171 1.00 13.51 ? 303 LYS A CE  1 
ATOM   2157 N NZ  . LYS A 1 275 ? 125.872 130.024 124.153 1.00 13.51 ? 303 LYS A NZ  1 
ATOM   2158 N N   . GLU A 1 276 ? 128.478 127.641 130.569 1.00 11.50 ? 304 GLU A N   1 
ATOM   2159 C CA  . GLU A 1 276 ? 129.669 128.406 130.921 1.00 11.50 ? 304 GLU A CA  1 
ATOM   2160 C C   . GLU A 1 276 ? 130.886 127.508 131.099 1.00 11.50 ? 304 GLU A C   1 
ATOM   2161 O O   . GLU A 1 276 ? 131.977 127.840 130.631 1.00 11.50 ? 304 GLU A O   1 
ATOM   2162 C CB  . GLU A 1 276 ? 129.407 129.213 132.192 1.00 11.50 ? 304 GLU A CB  1 
ATOM   2163 C CG  . GLU A 1 276 ? 130.554 130.111 132.621 1.00 11.50 ? 304 GLU A CG  1 
ATOM   2164 C CD  . GLU A 1 276 ? 131.247 130.778 131.452 1.00 11.50 ? 304 GLU A CD  1 
ATOM   2165 O OE1 . GLU A 1 276 ? 132.447 130.509 131.246 1.00 11.50 ? 304 GLU A OE1 1 
ATOM   2166 O OE2 . GLU A 1 276 ? 130.594 131.571 130.742 1.00 11.50 ? 304 GLU A OE2 1 
ATOM   2167 N N   . GLN A 1 277 ? 130.720 126.364 131.765 1.00 11.11 ? 305 GLN A N   1 
ATOM   2168 C CA  . GLN A 1 277 ? 131.869 125.511 132.061 1.00 11.11 ? 305 GLN A CA  1 
ATOM   2169 C C   . GLN A 1 277 ? 132.467 124.915 130.790 1.00 11.11 ? 305 GLN A C   1 
ATOM   2170 O O   . GLN A 1 277 ? 133.689 124.940 130.592 1.00 11.11 ? 305 GLN A O   1 
ATOM   2171 C CB  . GLN A 1 277 ? 131.460 124.408 133.035 1.00 11.11 ? 305 GLN A CB  1 
ATOM   2172 C CG  . GLN A 1 277 ? 131.460 124.849 134.485 1.00 11.11 ? 305 GLN A CG  1 
ATOM   2173 C CD  . GLN A 1 277 ? 132.670 125.694 134.833 1.00 11.11 ? 305 GLN A CD  1 
ATOM   2174 O OE1 . GLN A 1 277 ? 133.812 125.279 134.630 1.00 11.11 ? 305 GLN A OE1 1 
ATOM   2175 N NE2 . GLN A 1 277 ? 132.426 126.888 135.362 1.00 11.11 ? 305 GLN A NE2 1 
ATOM   2176 N N   . LYS A 1 278 ? 131.621 124.372 129.915 1.00 10.60 ? 306 LYS A N   1 
ATOM   2177 C CA  . LYS A 1 278 ? 132.122 123.785 128.678 1.00 10.60 ? 306 LYS A CA  1 
ATOM   2178 C C   . LYS A 1 278 ? 132.718 124.848 127.765 1.00 10.60 ? 306 LYS A C   1 
ATOM   2179 O O   . LYS A 1 278 ? 133.747 124.615 127.117 1.00 10.60 ? 306 LYS A O   1 
ATOM   2180 C CB  . LYS A 1 278 ? 131.003 123.021 127.977 1.00 10.60 ? 306 LYS A CB  1 
ATOM   2181 C CG  . LYS A 1 278 ? 130.430 121.896 128.822 1.00 10.60 ? 306 LYS A CG  1 
ATOM   2182 C CD  . LYS A 1 278 ? 129.237 121.244 128.157 1.00 10.60 ? 306 LYS A CD  1 
ATOM   2183 C CE  . LYS A 1 278 ? 128.649 120.157 129.034 1.00 10.60 ? 306 LYS A CE  1 
ATOM   2184 N NZ  . LYS A 1 278 ? 127.482 119.508 128.382 1.00 10.60 ? 306 LYS A NZ  1 
ATOM   2185 N N   . LEU A 1 279 ? 132.096 126.027 127.707 1.00 8.68  ? 307 LEU A N   1 
ATOM   2186 C CA  . LEU A 1 279 ? 132.657 127.102 126.896 1.00 8.68  ? 307 LEU A CA  1 
ATOM   2187 C C   . LEU A 1 279 ? 134.001 127.564 127.454 1.00 8.68  ? 307 LEU A C   1 
ATOM   2188 O O   . LEU A 1 279 ? 134.924 127.885 126.694 1.00 8.68  ? 307 LEU A O   1 
ATOM   2189 C CB  . LEU A 1 279 ? 131.662 128.258 126.813 1.00 8.68  ? 307 LEU A CB  1 
ATOM   2190 C CG  . LEU A 1 279 ? 131.972 129.379 125.827 1.00 8.68  ? 307 LEU A CG  1 
ATOM   2191 C CD1 . LEU A 1 279 ? 132.053 128.814 124.426 1.00 8.68  ? 307 LEU A CD1 1 
ATOM   2192 C CD2 . LEU A 1 279 ? 130.900 130.445 125.900 1.00 8.68  ? 307 LEU A CD2 1 
ATOM   2193 N N   . ARG A 1 280 ? 134.139 127.583 128.783 1.00 8.18  ? 308 ARG A N   1 
ATOM   2194 C CA  . ARG A 1 280 ? 135.419 127.924 129.395 1.00 8.18  ? 308 ARG A CA  1 
ATOM   2195 C C   . ARG A 1 280 ? 136.478 126.877 129.088 1.00 8.18  ? 308 ARG A C   1 
ATOM   2196 O O   . ARG A 1 280 ? 137.651 127.212 128.911 1.00 8.18  ? 308 ARG A O   1 
ATOM   2197 C CB  . ARG A 1 280 ? 135.255 128.088 130.905 1.00 8.18  ? 308 ARG A CB  1 
ATOM   2198 C CG  . ARG A 1 280 ? 136.531 128.498 131.623 1.00 8.18  ? 308 ARG A CG  1 
ATOM   2199 C CD  . ARG A 1 280 ? 136.234 129.370 132.829 1.00 8.18  ? 308 ARG A CD  1 
ATOM   2200 N NE  . ARG A 1 280 ? 135.810 130.713 132.446 1.00 8.18  ? 308 ARG A NE  1 
ATOM   2201 C CZ  . ARG A 1 280 ? 135.064 131.504 133.207 1.00 8.18  ? 308 ARG A CZ  1 
ATOM   2202 N NH1 . ARG A 1 280 ? 134.651 131.084 134.394 1.00 8.18  ? 308 ARG A NH1 1 
ATOM   2203 N NH2 . ARG A 1 280 ? 134.724 132.713 132.780 1.00 8.18  ? 308 ARG A NH2 1 
ATOM   2204 N N   . PHE A 1 281 ? 136.095 125.600 129.048 1.00 6.46  ? 309 PHE A N   1 
ATOM   2205 C CA  . PHE A 1 281 ? 137.050 124.568 128.651 1.00 6.46  ? 309 PHE A CA  1 
ATOM   2206 C C   . PHE A 1 281 ? 137.495 124.764 127.207 1.00 6.46  ? 309 PHE A C   1 
ATOM   2207 O O   . PHE A 1 281 ? 138.685 124.633 126.881 1.00 6.46  ? 309 PHE A O   1 
ATOM   2208 C CB  . PHE A 1 281 ? 136.443 123.182 128.840 1.00 6.46  ? 309 PHE A CB  1 
ATOM   2209 C CG  . PHE A 1 281 ? 137.457 122.081 128.865 1.00 6.46  ? 309 PHE A CG  1 
ATOM   2210 C CD1 . PHE A 1 281 ? 137.751 121.424 130.044 1.00 6.46  ? 309 PHE A CD1 1 
ATOM   2211 C CD2 . PHE A 1 281 ? 138.115 121.699 127.711 1.00 6.46  ? 309 PHE A CD2 1 
ATOM   2212 C CE1 . PHE A 1 281 ? 138.680 120.406 130.071 1.00 6.46  ? 309 PHE A CE1 1 
ATOM   2213 C CE2 . PHE A 1 281 ? 139.046 120.688 127.733 1.00 6.46  ? 309 PHE A CE2 1 
ATOM   2214 C CZ  . PHE A 1 281 ? 139.328 120.039 128.914 1.00 6.46  ? 309 PHE A CZ  1 
ATOM   2215 N N   . ALA A 1 282 ? 136.545 125.064 126.320 1.00 6.07  ? 310 ALA A N   1 
ATOM   2216 C CA  . ALA A 1 282 ? 136.907 125.345 124.936 1.00 6.07  ? 310 ALA A CA  1 
ATOM   2217 C C   . ALA A 1 282 ? 137.879 126.512 124.862 1.00 6.07  ? 310 ALA A C   1 
ATOM   2218 O O   . ALA A 1 282 ? 138.844 126.478 124.092 1.00 6.07  ? 310 ALA A O   1 
ATOM   2219 C CB  . ALA A 1 282 ? 135.656 125.631 124.108 1.00 6.07  ? 310 ALA A CB  1 
ATOM   2220 N N   . PHE A 1 283 ? 137.648 127.548 125.670 1.00 4.14  ? 311 PHE A N   1 
ATOM   2221 C CA  . PHE A 1 283 ? 138.592 128.660 125.743 1.00 4.14  ? 311 PHE A CA  1 
ATOM   2222 C C   . PHE A 1 283 ? 139.960 128.196 126.228 1.00 4.14  ? 311 PHE A C   1 
ATOM   2223 O O   . PHE A 1 283 ? 140.987 128.534 125.629 1.00 4.14  ? 311 PHE A O   1 
ATOM   2224 C CB  . PHE A 1 283 ? 138.044 129.747 126.665 1.00 4.14  ? 311 PHE A CB  1 
ATOM   2225 C CG  . PHE A 1 283 ? 138.840 131.019 126.649 1.00 4.14  ? 311 PHE A CG  1 
ATOM   2226 C CD1 . PHE A 1 283 ? 138.609 131.983 125.688 1.00 4.14  ? 311 PHE A CD1 1 
ATOM   2227 C CD2 . PHE A 1 283 ? 139.814 131.254 127.598 1.00 4.14  ? 311 PHE A CD2 1 
ATOM   2228 C CE1 . PHE A 1 283 ? 139.335 133.154 125.673 1.00 4.14  ? 311 PHE A CE1 1 
ATOM   2229 C CE2 . PHE A 1 283 ? 140.539 132.422 127.585 1.00 4.14  ? 311 PHE A CE2 1 
ATOM   2230 C CZ  . PHE A 1 283 ? 140.300 133.372 126.622 1.00 4.14  ? 311 PHE A CZ  1 
ATOM   2231 N N   . ARG A 1 284 ? 139.993 127.409 127.304 1.00 2.76  ? 312 ARG A N   1 
ATOM   2232 C CA  . ARG A 1 284 ? 141.246 126.981 127.914 1.00 2.76  ? 312 ARG A CA  1 
ATOM   2233 C C   . ARG A 1 284 ? 142.022 126.014 127.039 1.00 2.76  ? 312 ARG A C   1 
ATOM   2234 O O   . ARG A 1 284 ? 143.178 125.712 127.355 1.00 2.76  ? 312 ARG A O   1 
ATOM   2235 C CB  . ARG A 1 284 ? 140.985 126.341 129.275 1.00 2.76  ? 312 ARG A CB  1 
ATOM   2236 C CG  . ARG A 1 284 ? 141.192 127.283 130.446 1.00 2.76  ? 312 ARG A CG  1 
ATOM   2237 C CD  . ARG A 1 284 ? 141.161 126.537 131.764 1.00 2.76  ? 312 ARG A CD  1 
ATOM   2238 N NE  . ARG A 1 284 ? 139.877 126.670 132.443 1.00 2.76  ? 312 ARG A NE  1 
ATOM   2239 C CZ  . ARG A 1 284 ? 139.504 125.929 133.481 1.00 2.76  ? 312 ARG A CZ  1 
ATOM   2240 N NH1 . ARG A 1 284 ? 140.318 124.999 133.960 1.00 2.76  ? 312 ARG A NH1 1 
ATOM   2241 N NH2 . ARG A 1 284 ? 138.316 126.116 134.040 1.00 2.76  ? 312 ARG A NH2 1 
ATOM   2242 N N   . ILE A 1 285 ? 141.404 125.493 125.980 1.00 3.07  ? 313 ILE A N   1 
ATOM   2243 C CA  . ILE A 1 285 ? 142.173 124.750 124.983 1.00 3.07  ? 313 ILE A CA  1 
ATOM   2244 C C   . ILE A 1 285 ? 143.230 125.649 124.352 1.00 3.07  ? 313 ILE A C   1 
ATOM   2245 O O   . ILE A 1 285 ? 144.347 125.207 124.059 1.00 3.07  ? 313 ILE A O   1 
ATOM   2246 C CB  . ILE A 1 285 ? 141.244 124.139 123.917 1.00 3.07  ? 313 ILE A CB  1 
ATOM   2247 C CG1 . ILE A 1 285 ? 140.321 123.096 124.541 1.00 3.07  ? 313 ILE A CG1 1 
ATOM   2248 C CG2 . ILE A 1 285 ? 142.057 123.497 122.815 1.00 3.07  ? 313 ILE A CG2 1 
ATOM   2249 C CD1 . ILE A 1 285 ? 141.038 121.850 125.001 1.00 3.07  ? 313 ILE A CD1 1 
ATOM   2250 N N   . TYR A 1 286 ? 142.901 126.929 124.145 1.00 1.93  ? 314 TYR A N   1 
ATOM   2251 C CA  . TYR A 1 286 ? 143.785 127.826 123.404 1.00 1.93  ? 314 TYR A CA  1 
ATOM   2252 C C   . TYR A 1 286 ? 144.905 128.396 124.271 1.00 1.93  ? 314 TYR A C   1 
ATOM   2253 O O   . TYR A 1 286 ? 146.061 128.434 123.836 1.00 1.93  ? 314 TYR A O   1 
ATOM   2254 C CB  . TYR A 1 286 ? 142.970 128.957 122.777 1.00 1.93  ? 314 TYR A CB  1 
ATOM   2255 C CG  . TYR A 1 286 ? 141.986 128.490 121.727 1.00 1.93  ? 314 TYR A CG  1 
ATOM   2256 C CD1 . TYR A 1 286 ? 142.419 127.826 120.593 1.00 1.93  ? 314 TYR A CD1 1 
ATOM   2257 C CD2 . TYR A 1 286 ? 140.626 128.715 121.871 1.00 1.93  ? 314 TYR A CD2 1 
ATOM   2258 C CE1 . TYR A 1 286 ? 141.530 127.398 119.638 1.00 1.93  ? 314 TYR A CE1 1 
ATOM   2259 C CE2 . TYR A 1 286 ? 139.731 128.290 120.919 1.00 1.93  ? 314 TYR A CE2 1 
ATOM   2260 C CZ  . TYR A 1 286 ? 140.190 127.632 119.808 1.00 1.93  ? 314 TYR A CZ  1 
ATOM   2261 O OH  . TYR A 1 286 ? 139.300 127.207 118.859 1.00 1.93  ? 314 TYR A OH  1 
ATOM   2262 N N   . ASP A 1 287 ? 144.590 128.854 125.485 1.00 2.07  ? 315 ASP A N   1 
ATOM   2263 C CA  . ASP A 1 287 ? 145.592 129.417 126.387 1.00 2.07  ? 315 ASP A CA  1 
ATOM   2264 C C   . ASP A 1 287 ? 146.740 128.449 126.629 1.00 2.07  ? 315 ASP A C   1 
ATOM   2265 O O   . ASP A 1 287 ? 146.546 127.397 127.243 1.00 2.07  ? 315 ASP A O   1 
ATOM   2266 C CB  . ASP A 1 287 ? 144.969 129.777 127.734 1.00 2.07  ? 315 ASP A CB  1 
ATOM   2267 C CG  . ASP A 1 287 ? 143.977 130.898 127.636 1.00 2.07  ? 315 ASP A CG  1 
ATOM   2268 O OD1 . ASP A 1 287 ? 144.215 131.833 126.851 1.00 2.07  ? 315 ASP A OD1 1 
ATOM   2269 O OD2 . ASP A 1 287 ? 142.961 130.850 128.355 1.00 2.07  ? 315 ASP A OD2 1 
ATOM   2270 N N   . MET A 1 288 ? 147.938 128.794 126.176 1.00 2.41  ? 316 MET A N   1 
ATOM   2271 C CA  . MET A 1 288 ? 149.104 127.957 126.413 1.00 2.41  ? 316 MET A CA  1 
ATOM   2272 C C   . MET A 1 288 ? 149.878 128.371 127.659 1.00 2.41  ? 316 MET A C   1 
ATOM   2273 O O   . MET A 1 288 ? 150.956 127.826 127.915 1.00 2.41  ? 316 MET A O   1 
ATOM   2274 C CB  . MET A 1 288 ? 150.017 127.964 125.187 1.00 2.41  ? 316 MET A CB  1 
ATOM   2275 C CG  . MET A 1 288 ? 149.398 127.298 123.970 1.00 2.41  ? 316 MET A CG  1 
ATOM   2276 S SD  . MET A 1 288 ? 150.444 127.384 122.509 1.00 2.41  ? 316 MET A SD  1 
ATOM   2277 C CE  . MET A 1 288 ? 151.756 126.259 122.964 1.00 2.41  ? 316 MET A CE  1 
ATOM   2278 N N   . ASP A 1 289 ? 149.351 129.321 128.434 1.00 4.85  ? 317 ASP A N   1 
ATOM   2279 C CA  . ASP A 1 289 ? 149.957 129.743 129.687 1.00 4.85  ? 317 ASP A CA  1 
ATOM   2280 C C   . ASP A 1 289 ? 148.954 129.848 130.826 1.00 4.85  ? 317 ASP A C   1 
ATOM   2281 O O   . ASP A 1 289 ? 149.357 130.144 131.955 1.00 4.85  ? 317 ASP A O   1 
ATOM   2282 C CB  . ASP A 1 289 ? 150.661 131.097 129.517 1.00 4.85  ? 317 ASP A CB  1 
ATOM   2283 C CG  . ASP A 1 289 ? 152.088 130.956 129.030 1.00 4.85  ? 317 ASP A CG  1 
ATOM   2284 O OD1 . ASP A 1 289 ? 152.716 131.990 128.718 1.00 4.85  ? 317 ASP A OD1 1 
ATOM   2285 O OD2 . ASP A 1 289 ? 152.582 129.812 128.961 1.00 4.85  ? 317 ASP A OD2 1 
ATOM   2286 N N   . LYS A 1 290 ? 147.667 129.624 130.562 1.00 3.21  ? 318 LYS A N   1 
ATOM   2287 C CA  . LYS A 1 290 ? 146.593 129.737 131.547 1.00 3.21  ? 318 LYS A CA  1 
ATOM   2288 C C   . LYS A 1 290 ? 146.521 131.123 132.174 1.00 3.21  ? 318 LYS A C   1 
ATOM   2289 O O   . LYS A 1 290 ? 145.915 131.295 133.234 1.00 3.21  ? 318 LYS A O   1 
ATOM   2290 C CB  . LYS A 1 290 ? 146.719 128.671 132.643 1.00 3.21  ? 318 LYS A CB  1 
ATOM   2291 C CG  . LYS A 1 290 ? 146.669 127.235 132.137 1.00 3.21  ? 318 LYS A CG  1 
ATOM   2292 C CD  . LYS A 1 290 ? 146.100 126.302 133.195 1.00 3.21  ? 318 LYS A CD  1 
ATOM   2293 C CE  . LYS A 1 290 ? 146.670 124.902 133.072 1.00 3.21  ? 318 LYS A CE  1 
ATOM   2294 N NZ  . LYS A 1 290 ? 148.120 124.856 133.406 1.00 3.21  ? 318 LYS A NZ  1 
ATOM   2295 N N   . ASP A 1 291 ? 147.119 132.126 131.531 1.00 3.24  ? 319 ASP A N   1 
ATOM   2296 C CA  . ASP A 1 291 ? 147.126 133.478 132.070 1.00 3.24  ? 319 ASP A CA  1 
ATOM   2297 C C   . ASP A 1 291 ? 145.859 134.257 131.750 1.00 3.24  ? 319 ASP A C   1 
ATOM   2298 O O   . ASP A 1 291 ? 145.690 135.366 132.266 1.00 3.24  ? 319 ASP A O   1 
ATOM   2299 C CB  . ASP A 1 291 ? 148.353 134.236 131.558 1.00 3.24  ? 319 ASP A CB  1 
ATOM   2300 C CG  . ASP A 1 291 ? 148.545 134.093 130.066 1.00 3.24  ? 319 ASP A CG  1 
ATOM   2301 O OD1 . ASP A 1 291 ? 147.705 133.437 129.418 1.00 3.24  ? 319 ASP A OD1 1 
ATOM   2302 O OD2 . ASP A 1 291 ? 149.546 134.624 129.542 1.00 3.24  ? 319 ASP A OD2 1 
ATOM   2303 N N   . GLY A 1 292 ? 144.968 133.709 130.929 1.00 2.94  ? 320 GLY A N   1 
ATOM   2304 C CA  . GLY A 1 292 ? 143.680 134.316 130.657 1.00 2.94  ? 320 GLY A CA  1 
ATOM   2305 C C   . GLY A 1 292 ? 143.565 135.024 129.325 1.00 2.94  ? 320 GLY A C   1 
ATOM   2306 O O   . GLY A 1 292 ? 142.469 135.494 128.994 1.00 2.94  ? 320 GLY A O   1 
ATOM   2307 N N   . TYR A 1 293 ? 144.640 135.115 128.546 1.00 2.49  ? 321 TYR A N   1 
ATOM   2308 C CA  . TYR A 1 293 ? 144.621 135.838 127.285 1.00 2.49  ? 321 TYR A CA  1 
ATOM   2309 C C   . TYR A 1 293 ? 145.207 134.980 126.174 1.00 2.49  ? 321 TYR A C   1 
ATOM   2310 O O   . TYR A 1 293 ? 146.159 134.224 126.387 1.00 2.49  ? 321 TYR A O   1 
ATOM   2311 C CB  . TYR A 1 293 ? 145.399 137.158 127.383 1.00 2.49  ? 321 TYR A CB  1 
ATOM   2312 C CG  . TYR A 1 293 ? 144.689 138.241 128.164 1.00 2.49  ? 321 TYR A CG  1 
ATOM   2313 C CD1 . TYR A 1 293 ? 143.305 138.302 128.200 1.00 2.49  ? 321 TYR A CD1 1 
ATOM   2314 C CD2 . TYR A 1 293 ? 145.403 139.204 128.860 1.00 2.49  ? 321 TYR A CD2 1 
ATOM   2315 C CE1 . TYR A 1 293 ? 142.653 139.287 128.910 1.00 2.49  ? 321 TYR A CE1 1 
ATOM   2316 C CE2 . TYR A 1 293 ? 144.758 140.193 129.573 1.00 2.49  ? 321 TYR A CE2 1 
ATOM   2317 C CZ  . TYR A 1 293 ? 143.383 140.230 129.593 1.00 2.49  ? 321 TYR A CZ  1 
ATOM   2318 O OH  . TYR A 1 293 ? 142.730 141.211 130.301 1.00 2.49  ? 321 TYR A OH  1 
ATOM   2319 N N   . ILE A 1 294 ? 144.630 135.116 124.981 1.00 2.71  ? 322 ILE A N   1 
ATOM   2320 C CA  . ILE A 1 294 ? 145.092 134.419 123.785 1.00 2.71  ? 322 ILE A CA  1 
ATOM   2321 C C   . ILE A 1 294 ? 145.860 135.416 122.929 1.00 2.71  ? 322 ILE A C   1 
ATOM   2322 O O   . ILE A 1 294 ? 145.294 136.409 122.459 1.00 2.71  ? 322 ILE A O   1 
ATOM   2323 C CB  . ILE A 1 294 ? 143.926 133.810 122.990 1.00 2.71  ? 322 ILE A CB  1 
ATOM   2324 C CG1 . ILE A 1 294 ? 143.099 132.869 123.854 1.00 2.71  ? 322 ILE A CG1 1 
ATOM   2325 C CG2 . ILE A 1 294 ? 144.452 133.026 121.812 1.00 2.71  ? 322 ILE A CG2 1 
ATOM   2326 C CD1 . ILE A 1 294 ? 141.822 132.441 123.195 1.00 2.71  ? 322 ILE A CD1 1 
ATOM   2327 N N   . SER A 1 295 ? 147.143 135.152 122.721 1.00 4.37  ? 323 SER A N   1 
ATOM   2328 C CA  . SER A 1 295 ? 147.994 136.028 121.934 1.00 4.37  ? 323 SER A CA  1 
ATOM   2329 C C   . SER A 1 295 ? 147.938 135.617 120.465 1.00 4.37  ? 323 SER A C   1 
ATOM   2330 O O   . SER A 1 295 ? 147.090 134.826 120.049 1.00 4.37  ? 323 SER A O   1 
ATOM   2331 C CB  . SER A 1 295 ? 149.420 136.000 122.476 1.00 4.37  ? 323 SER A CB  1 
ATOM   2332 O OG  . SER A 1 295 ? 150.332 136.529 121.533 1.00 4.37  ? 323 SER A OG  1 
ATOM   2333 N N   . ASN A 1 296 ? 148.833 136.179 119.654 1.00 6.81  ? 324 ASN A N   1 
ATOM   2334 C CA  . ASN A 1 296 ? 148.974 135.730 118.275 1.00 6.81  ? 324 ASN A CA  1 
ATOM   2335 C C   . ASN A 1 296 ? 149.708 134.397 118.201 1.00 6.81  ? 324 ASN A C   1 
ATOM   2336 O O   . ASN A 1 296 ? 149.318 133.512 117.432 1.00 6.81  ? 324 ASN A O   1 
ATOM   2337 C CB  . ASN A 1 296 ? 149.701 136.799 117.458 1.00 6.81  ? 324 ASN A CB  1 
ATOM   2338 C CG  . ASN A 1 296 ? 149.797 136.457 115.986 1.00 6.81  ? 324 ASN A CG  1 
ATOM   2339 O OD1 . ASN A 1 296 ? 149.230 135.474 115.522 1.00 6.81  ? 324 ASN A OD1 1 
ATOM   2340 N ND2 . ASN A 1 296 ? 150.524 137.277 115.240 1.00 6.81  ? 324 ASN A ND2 1 
ATOM   2341 N N   . GLY A 1 297 ? 150.762 134.229 119.000 1.00 7.06  ? 325 GLY A N   1 
ATOM   2342 C CA  . GLY A 1 297 ? 151.521 132.990 118.955 1.00 7.06  ? 325 GLY A CA  1 
ATOM   2343 C C   . GLY A 1 297 ? 150.727 131.794 119.440 1.00 7.06  ? 325 GLY A C   1 
ATOM   2344 O O   . GLY A 1 297 ? 150.825 130.701 118.876 1.00 7.06  ? 325 GLY A O   1 
ATOM   2345 N N   . GLU A 1 298 ? 149.924 131.984 120.484 1.00 3.98  ? 326 GLU A N   1 
ATOM   2346 C CA  . GLU A 1 298 ? 149.124 130.885 121.010 1.00 3.98  ? 326 GLU A CA  1 
ATOM   2347 C C   . GLU A 1 298 ? 148.063 130.446 120.005 1.00 3.98  ? 326 GLU A C   1 
ATOM   2348 O O   . GLU A 1 298 ? 147.947 129.253 119.688 1.00 3.98  ? 326 GLU A O   1 
ATOM   2349 C CB  . GLU A 1 298 ? 148.504 131.302 122.344 1.00 3.98  ? 326 GLU A CB  1 
ATOM   2350 C CG  . GLU A 1 298 ? 149.559 131.592 123.417 1.00 3.98  ? 326 GLU A CG  1 
ATOM   2351 C CD  . GLU A 1 298 ? 149.053 132.455 124.561 1.00 3.98  ? 326 GLU A CD  1 
ATOM   2352 O OE1 . GLU A 1 298 ? 147.933 132.991 124.463 1.00 3.98  ? 326 GLU A OE1 1 
ATOM   2353 O OE2 . GLU A 1 298 ? 149.785 132.602 125.561 1.00 3.98  ? 326 GLU A OE2 1 
ATOM   2354 N N   . LEU A 1 299 ? 147.291 131.399 119.475 1.00 3.24  ? 327 LEU A N   1 
ATOM   2355 C CA  . LEU A 1 299 ? 146.266 131.075 118.489 1.00 3.24  ? 327 LEU A CA  1 
ATOM   2356 C C   . LEU A 1 299 ? 146.856 130.635 117.159 1.00 3.24  ? 327 LEU A C   1 
ATOM   2357 O O   . LEU A 1 299 ? 146.138 130.053 116.344 1.00 3.24  ? 327 LEU A O   1 
ATOM   2358 C CB  . LEU A 1 299 ? 145.343 132.273 118.270 1.00 3.24  ? 327 LEU A CB  1 
ATOM   2359 C CG  . LEU A 1 299 ? 144.085 132.050 117.433 1.00 3.24  ? 327 LEU A CG  1 
ATOM   2360 C CD1 . LEU A 1 299 ? 143.337 130.852 117.940 1.00 3.24  ? 327 LEU A CD1 1 
ATOM   2361 C CD2 . LEU A 1 299 ? 143.202 133.271 117.462 1.00 3.24  ? 327 LEU A CD2 1 
ATOM   2362 N N   . PHE A 1 300 ? 148.136 130.901 116.909 1.00 10.41 ? 328 PHE A N   1 
ATOM   2363 C CA  . PHE A 1 300 ? 148.735 130.371 115.693 1.00 10.41 ? 328 PHE A CA  1 
ATOM   2364 C C   . PHE A 1 300 ? 149.231 128.947 115.892 1.00 10.41 ? 328 PHE A C   1 
ATOM   2365 O O   . PHE A 1 300 ? 149.033 128.098 115.021 1.00 10.41 ? 328 PHE A O   1 
ATOM   2366 C CB  . PHE A 1 300 ? 149.880 131.258 115.220 1.00 10.41 ? 328 PHE A CB  1 
ATOM   2367 C CG  . PHE A 1 300 ? 150.741 130.617 114.174 1.00 10.41 ? 328 PHE A CG  1 
ATOM   2368 C CD1 . PHE A 1 300 ? 150.369 130.637 112.849 1.00 10.41 ? 328 PHE A CD1 1 
ATOM   2369 C CD2 . PHE A 1 300 ? 151.924 129.996 114.516 1.00 10.41 ? 328 PHE A CD2 1 
ATOM   2370 C CE1 . PHE A 1 300 ? 151.160 130.050 111.889 1.00 10.41 ? 328 PHE A CE1 1 
ATOM   2371 C CE2 . PHE A 1 300 ? 152.714 129.409 113.559 1.00 10.41 ? 328 PHE A CE2 1 
ATOM   2372 C CZ  . PHE A 1 300 ? 152.332 129.437 112.247 1.00 10.41 ? 328 PHE A CZ  1 
ATOM   2373 N N   . GLN A 1 301 ? 149.878 128.656 117.023 1.00 8.48  ? 329 GLN A N   1 
ATOM   2374 C CA  . GLN A 1 301 ? 150.404 127.309 117.222 1.00 8.48  ? 329 GLN A CA  1 
ATOM   2375 C C   . GLN A 1 301 ? 149.294 126.301 117.493 1.00 8.48  ? 329 GLN A C   1 
ATOM   2376 O O   . GLN A 1 301 ? 149.405 125.135 117.083 1.00 8.48  ? 329 GLN A O   1 
ATOM   2377 C CB  . GLN A 1 301 ? 151.430 127.308 118.349 1.00 8.48  ? 329 GLN A CB  1 
ATOM   2378 C CG  . GLN A 1 301 ? 152.848 127.531 117.857 1.00 8.48  ? 329 GLN A CG  1 
ATOM   2379 C CD  . GLN A 1 301 ? 153.774 128.015 118.949 1.00 8.48  ? 329 GLN A CD  1 
ATOM   2380 O OE1 . GLN A 1 301 ? 153.336 128.620 119.927 1.00 8.48  ? 329 GLN A OE1 1 
ATOM   2381 N NE2 . GLN A 1 301 ? 155.066 127.752 118.789 1.00 8.48  ? 329 GLN A NE2 1 
ATOM   2382 N N   . VAL A 1 302 ? 148.212 126.728 118.150 1.00 5.38  ? 330 VAL A N   1 
ATOM   2383 C CA  . VAL A 1 302 ? 147.082 125.828 118.362 1.00 5.38  ? 330 VAL A CA  1 
ATOM   2384 C C   . VAL A 1 302 ? 146.511 125.363 117.028 1.00 5.38  ? 330 VAL A C   1 
ATOM   2385 O O   . VAL A 1 302 ? 146.195 124.181 116.850 1.00 5.38  ? 330 VAL A O   1 
ATOM   2386 C CB  . VAL A 1 302 ? 146.011 126.511 119.227 1.00 5.38  ? 330 VAL A CB  1 
ATOM   2387 C CG1 . VAL A 1 302 ? 144.690 125.799 119.074 1.00 5.38  ? 330 VAL A CG1 1 
ATOM   2388 C CG2 . VAL A 1 302 ? 146.441 126.526 120.676 1.00 5.38  ? 330 VAL A CG2 1 
ATOM   2389 N N   . LEU A 1 303 ? 146.364 126.279 116.072 1.00 3.82  ? 331 LEU A N   1 
ATOM   2390 C CA  . LEU A 1 303 ? 145.874 125.904 114.753 1.00 3.82  ? 331 LEU A CA  1 
ATOM   2391 C C   . LEU A 1 303 ? 146.935 125.232 113.900 1.00 3.82  ? 331 LEU A C   1 
ATOM   2392 O O   . LEU A 1 303 ? 146.586 124.480 112.986 1.00 3.82  ? 331 LEU A O   1 
ATOM   2393 C CB  . LEU A 1 303 ? 145.338 127.127 114.020 1.00 3.82  ? 331 LEU A CB  1 
ATOM   2394 C CG  . LEU A 1 303 ? 144.181 127.819 114.727 1.00 3.82  ? 331 LEU A CG  1 
ATOM   2395 C CD1 . LEU A 1 303 ? 143.714 128.987 113.900 1.00 3.82  ? 331 LEU A CD1 1 
ATOM   2396 C CD2 . LEU A 1 303 ? 143.052 126.850 114.973 1.00 3.82  ? 331 LEU A CD2 1 
ATOM   2397 N N   . LYS A 1 304 ? 148.215 125.483 114.165 1.00 4.96  ? 332 LYS A N   1 
ATOM   2398 C CA  . LYS A 1 304 ? 149.250 124.833 113.375 1.00 4.96  ? 332 LYS A CA  1 
ATOM   2399 C C   . LYS A 1 304 ? 149.413 123.368 113.753 1.00 4.96  ? 332 LYS A C   1 
ATOM   2400 O O   . LYS A 1 304 ? 149.813 122.559 112.910 1.00 4.96  ? 332 LYS A O   1 
ATOM   2401 C CB  . LYS A 1 304 ? 150.577 125.566 113.526 1.00 4.96  ? 332 LYS A CB  1 
ATOM   2402 C CG  . LYS A 1 304 ? 151.597 125.168 112.483 1.00 4.96  ? 332 LYS A CG  1 
ATOM   2403 C CD  . LYS A 1 304 ? 151.012 125.309 111.092 1.00 4.96  ? 332 LYS A CD  1 
ATOM   2404 C CE  . LYS A 1 304 ? 152.078 125.172 110.023 1.00 4.96  ? 332 LYS A CE  1 
ATOM   2405 N NZ  . LYS A 1 304 ? 151.609 125.712 108.718 1.00 4.96  ? 332 LYS A NZ  1 
ATOM   2406 N N   . MET A 1 305 ? 149.123 123.000 115.004 1.00 10.41 ? 333 MET A N   1 
ATOM   2407 C CA  . MET A 1 305 ? 149.169 121.575 115.325 1.00 10.41 ? 333 MET A CA  1 
ATOM   2408 C C   . MET A 1 305 ? 147.981 120.820 114.749 1.00 10.41 ? 333 MET A C   1 
ATOM   2409 O O   . MET A 1 305 ? 148.041 119.593 114.634 1.00 10.41 ? 333 MET A O   1 
ATOM   2410 C CB  . MET A 1 305 ? 149.232 121.331 116.835 1.00 10.41 ? 333 MET A CB  1 
ATOM   2411 C CG  . MET A 1 305 ? 148.014 121.775 117.616 1.00 10.41 ? 333 MET A CG  1 
ATOM   2412 S SD  . MET A 1 305 ? 148.238 121.528 119.388 1.00 10.41 ? 333 MET A SD  1 
ATOM   2413 C CE  . MET A 1 305 ? 149.396 122.836 119.771 1.00 10.41 ? 333 MET A CE  1 
ATOM   2414 N N   . MET A 1 306 ? 146.912 121.521 114.377 1.00 5.41  ? 334 MET A N   1 
ATOM   2415 C CA  . MET A 1 306 ? 145.708 120.888 113.855 1.00 5.41  ? 334 MET A CA  1 
ATOM   2416 C C   . MET A 1 306 ? 145.702 120.819 112.331 1.00 5.41  ? 334 MET A C   1 
ATOM   2417 O O   . MET A 1 306 ? 145.510 119.742 111.759 1.00 5.41  ? 334 MET A O   1 
ATOM   2418 C CB  . MET A 1 306 ? 144.475 121.645 114.344 1.00 5.41  ? 334 MET A CB  1 
ATOM   2419 C CG  . MET A 1 306 ? 144.093 121.325 115.760 1.00 5.41  ? 334 MET A CG  1 
ATOM   2420 S SD  . MET A 1 306 ? 142.351 121.611 116.077 1.00 5.41  ? 334 MET A SD  1 
ATOM   2421 C CE  . MET A 1 306 ? 142.480 122.535 117.598 1.00 5.41  ? 334 MET A CE  1 
ATOM   2422 N N   . VAL A 1 307 ? 145.904 121.956 111.657 1.00 5.15  ? 335 VAL A N   1 
ATOM   2423 C CA  . VAL A 1 307 ? 145.831 121.983 110.200 1.00 5.15  ? 335 VAL A CA  1 
ATOM   2424 C C   . VAL A 1 307 ? 147.026 121.329 109.534 1.00 5.15  ? 335 VAL A C   1 
ATOM   2425 O O   . VAL A 1 307 ? 146.997 121.109 108.320 1.00 5.15  ? 335 VAL A O   1 
ATOM   2426 C CB  . VAL A 1 307 ? 145.714 123.422 109.662 1.00 5.15  ? 335 VAL A CB  1 
ATOM   2427 C CG1 . VAL A 1 307 ? 144.597 124.150 110.358 1.00 5.15  ? 335 VAL A CG1 1 
ATOM   2428 C CG2 . VAL A 1 307 ? 147.028 124.155 109.806 1.00 5.15  ? 335 VAL A CG2 1 
ATOM   2429 N N   . GLY A 1 308 ? 148.074 121.018 110.288 1.00 6.38  ? 336 GLY A N   1 
ATOM   2430 C CA  . GLY A 1 308 ? 149.239 120.385 109.694 1.00 6.38  ? 336 GLY A CA  1 
ATOM   2431 C C   . GLY A 1 308 ? 149.874 121.273 108.645 1.00 6.38  ? 336 GLY A C   1 
ATOM   2432 O O   . GLY A 1 308 ? 150.160 122.451 108.881 1.00 6.38  ? 336 GLY A O   1 
ATOM   2433 N N   . ASN A 1 309 ? 150.095 120.707 107.464 1.00 9.05  ? 337 ASN A N   1 
ATOM   2434 C CA  . ASN A 1 309 ? 150.726 121.406 106.353 1.00 9.05  ? 337 ASN A CA  1 
ATOM   2435 C C   . ASN A 1 309 ? 149.752 121.561 105.189 1.00 9.05  ? 337 ASN A C   1 
ATOM   2436 O O   . ASN A 1 309 ? 150.132 121.482 104.020 1.00 9.05  ? 337 ASN A O   1 
ATOM   2437 C CB  . ASN A 1 309 ? 151.992 120.678 105.911 1.00 9.05  ? 337 ASN A CB  1 
ATOM   2438 C CG  . ASN A 1 309 ? 152.904 121.549 105.077 1.00 9.05  ? 337 ASN A CG  1 
ATOM   2439 O OD1 . ASN A 1 309 ? 152.616 122.721 104.846 1.00 9.05  ? 337 ASN A OD1 1 
ATOM   2440 N ND2 . ASN A 1 309 ? 154.012 120.980 104.619 1.00 9.05  ? 337 ASN A ND2 1 
ATOM   2441 N N   . ASN A 1 310 ? 148.474 121.778 105.501 1.00 6.40  ? 338 ASN A N   1 
ATOM   2442 C CA  . ASN A 1 310 ? 147.457 121.966 104.475 1.00 6.40  ? 338 ASN A CA  1 
ATOM   2443 C C   . ASN A 1 310 ? 147.313 123.414 104.033 1.00 6.40  ? 338 ASN A C   1 
ATOM   2444 O O   . ASN A 1 310 ? 146.731 123.667 102.972 1.00 6.40  ? 338 ASN A O   1 
ATOM   2445 C CB  . ASN A 1 310 ? 146.106 121.455 104.973 1.00 6.40  ? 338 ASN A CB  1 
ATOM   2446 C CG  . ASN A 1 310 ? 146.010 119.952 104.928 1.00 6.40  ? 338 ASN A CG  1 
ATOM   2447 O OD1 . ASN A 1 310 ? 146.997 119.264 104.676 1.00 6.40  ? 338 ASN A OD1 1 
ATOM   2448 N ND2 . ASN A 1 310 ? 144.820 119.429 105.180 1.00 6.40  ? 338 ASN A ND2 1 
ATOM   2449 N N   . LEU A 1 311 ? 147.820 124.363 104.814 1.00 6.80  ? 339 LEU A N   1 
ATOM   2450 C CA  . LEU A 1 311 ? 147.858 125.766 104.436 1.00 6.80  ? 339 LEU A CA  1 
ATOM   2451 C C   . LEU A 1 311 ? 149.290 126.268 104.533 1.00 6.80  ? 339 LEU A C   1 
ATOM   2452 O O   . LEU A 1 311 ? 150.084 125.774 105.339 1.00 6.80  ? 339 LEU A O   1 
ATOM   2453 C CB  . LEU A 1 311 ? 146.956 126.626 105.330 1.00 6.80  ? 339 LEU A CB  1 
ATOM   2454 C CG  . LEU A 1 311 ? 145.559 126.123 105.688 1.00 6.80  ? 339 LEU A CG  1 
ATOM   2455 C CD1 . LEU A 1 311 ? 144.810 127.177 106.470 1.00 6.80  ? 339 LEU A CD1 1 
ATOM   2456 C CD2 . LEU A 1 311 ? 144.789 125.757 104.448 1.00 6.80  ? 339 LEU A CD2 1 
ATOM   2457 N N   . LYS A 1 312 ? 149.617 127.252 103.702 1.00 10.44 ? 340 LYS A N   1 
ATOM   2458 C CA  . LYS A 1 312 ? 150.913 127.902 103.810 1.00 10.44 ? 340 LYS A CA  1 
ATOM   2459 C C   . LYS A 1 312 ? 151.038 128.584 105.166 1.00 10.44 ? 340 LYS A C   1 
ATOM   2460 O O   . LYS A 1 312 ? 150.043 128.979 105.780 1.00 10.44 ? 340 LYS A O   1 
ATOM   2461 C CB  . LYS A 1 312 ? 151.091 128.934 102.695 1.00 10.44 ? 340 LYS A CB  1 
ATOM   2462 C CG  . LYS A 1 312 ? 151.078 128.373 101.285 1.00 10.44 ? 340 LYS A CG  1 
ATOM   2463 C CD  . LYS A 1 312 ? 152.348 127.604 100.984 1.00 10.44 ? 340 LYS A CD  1 
ATOM   2464 C CE  . LYS A 1 312 ? 152.344 127.097 99.554  1.00 10.44 ? 340 LYS A CE  1 
ATOM   2465 N NZ  . LYS A 1 312 ? 152.419 128.220 98.579  1.00 10.44 ? 340 LYS A NZ  1 
ATOM   2466 N N   . ASP A 1 313 ? 152.276 128.712 105.642 1.00 9.49  ? 341 ASP A N   1 
ATOM   2467 C CA  . ASP A 1 313 ? 152.502 129.406 106.905 1.00 9.49  ? 341 ASP A CA  1 
ATOM   2468 C C   . ASP A 1 313 ? 152.025 130.851 106.824 1.00 9.49  ? 341 ASP A C   1 
ATOM   2469 O O   . ASP A 1 313 ? 151.370 131.353 107.747 1.00 9.49  ? 341 ASP A O   1 
ATOM   2470 C CB  . ASP A 1 313 ? 153.983 129.344 107.273 1.00 9.49  ? 341 ASP A CB  1 
ATOM   2471 C CG  . ASP A 1 313 ? 154.236 129.663 108.730 1.00 9.49  ? 341 ASP A CG  1 
ATOM   2472 O OD1 . ASP A 1 313 ? 155.401 129.553 109.168 1.00 9.49  ? 341 ASP A OD1 1 
ATOM   2473 O OD2 . ASP A 1 313 ? 153.274 130.024 109.436 1.00 9.49  ? 341 ASP A OD2 1 
ATOM   2474 N N   . THR A 1 314 ? 152.328 131.525 105.714 1.00 8.44  ? 342 THR A N   1 
ATOM   2475 C CA  . THR A 1 314 ? 151.923 132.916 105.551 1.00 8.44  ? 342 THR A CA  1 
ATOM   2476 C C   . THR A 1 314 ? 150.406 133.056 105.543 1.00 8.44  ? 342 THR A C   1 
ATOM   2477 O O   . THR A 1 314 ? 149.859 133.993 106.135 1.00 8.44  ? 342 THR A O   1 
ATOM   2478 C CB  . THR A 1 314 ? 152.522 133.482 104.266 1.00 8.44  ? 342 THR A CB  1 
ATOM   2479 O OG1 . THR A 1 314 ? 152.129 132.667 103.157 1.00 8.44  ? 342 THR A OG1 1 
ATOM   2480 C CG2 . THR A 1 314 ? 154.037 133.502 104.354 1.00 8.44  ? 342 THR A CG2 1 
ATOM   2481 N N   . GLN A 1 315 ? 149.708 132.136 104.874 1.00 8.66  ? 343 GLN A N   1 
ATOM   2482 C CA  . GLN A 1 315 ? 148.251 132.208 104.826 1.00 8.66  ? 343 GLN A CA  1 
ATOM   2483 C C   . GLN A 1 315 ? 147.642 132.050 106.213 1.00 8.66  ? 343 GLN A C   1 
ATOM   2484 O O   . GLN A 1 315 ? 146.727 132.796 106.589 1.00 8.66  ? 343 GLN A O   1 
ATOM   2485 C CB  . GLN A 1 315 ? 147.708 131.144 103.874 1.00 8.66  ? 343 GLN A CB  1 
ATOM   2486 C CG  . GLN A 1 315 ? 148.038 131.401 102.414 1.00 8.66  ? 343 GLN A CG  1 
ATOM   2487 C CD  . GLN A 1 315 ? 147.965 130.150 101.567 1.00 8.66  ? 343 GLN A CD  1 
ATOM   2488 O OE1 . GLN A 1 315 ? 147.691 129.063 102.068 1.00 8.66  ? 343 GLN A OE1 1 
ATOM   2489 N NE2 . GLN A 1 315 ? 148.212 130.299 100.273 1.00 8.66  ? 343 GLN A NE2 1 
ATOM   2490 N N   . LEU A 1 316 ? 148.134 131.082 106.988 1.00 5.37  ? 344 LEU A N   1 
ATOM   2491 C CA  . LEU A 1 316 ? 147.611 130.888 108.335 1.00 5.37  ? 344 LEU A CA  1 
ATOM   2492 C C   . LEU A 1 316 ? 147.889 132.102 109.209 1.00 5.37  ? 344 LEU A C   1 
ATOM   2493 O O   . LEU A 1 316 ? 147.009 132.556 109.953 1.00 5.37  ? 344 LEU A O   1 
ATOM   2494 C CB  . LEU A 1 316 ? 148.205 129.624 108.950 1.00 5.37  ? 344 LEU A CB  1 
ATOM   2495 C CG  . LEU A 1 316 ? 147.746 129.254 110.357 1.00 5.37  ? 344 LEU A CG  1 
ATOM   2496 C CD1 . LEU A 1 316 ? 146.243 129.363 110.491 1.00 5.37  ? 344 LEU A CD1 1 
ATOM   2497 C CD2 . LEU A 1 316 ? 148.189 127.843 110.659 1.00 5.37  ? 344 LEU A CD2 1 
ATOM   2498 N N   . GLN A 1 317 ? 149.096 132.660 109.114 1.00 6.57  ? 345 GLN A N   1 
ATOM   2499 C CA  . GLN A 1 317 ? 149.398 133.855 109.894 1.00 6.57  ? 345 GLN A CA  1 
ATOM   2500 C C   . GLN A 1 317 ? 148.482 135.009 109.507 1.00 6.57  ? 345 GLN A C   1 
ATOM   2501 O O   . GLN A 1 317 ? 148.021 135.759 110.373 1.00 6.57  ? 345 GLN A O   1 
ATOM   2502 C CB  . GLN A 1 317 ? 150.862 134.248 109.717 1.00 6.57  ? 345 GLN A CB  1 
ATOM   2503 C CG  . GLN A 1 317 ? 151.279 135.439 110.549 1.00 6.57  ? 345 GLN A CG  1 
ATOM   2504 C CD  . GLN A 1 317 ? 151.270 135.151 112.031 1.00 6.57  ? 345 GLN A CD  1 
ATOM   2505 O OE1 . GLN A 1 317 ? 152.281 134.744 112.596 1.00 6.57  ? 345 GLN A OE1 1 
ATOM   2506 N NE2 . GLN A 1 317 ? 150.132 135.374 112.673 1.00 6.57  ? 345 GLN A NE2 1 
ATOM   2507 N N   . GLN A 1 318 ? 148.205 135.164 108.210 1.00 4.92  ? 346 GLN A N   1 
ATOM   2508 C CA  . GLN A 1 318 ? 147.363 136.267 107.757 1.00 4.92  ? 346 GLN A CA  1 
ATOM   2509 C C   . GLN A 1 318 ? 145.932 136.124 108.258 1.00 4.92  ? 346 GLN A C   1 
ATOM   2510 O O   . GLN A 1 318 ? 145.331 137.103 108.727 1.00 4.92  ? 346 GLN A O   1 
ATOM   2511 C CB  . GLN A 1 318 ? 147.392 136.352 106.233 1.00 4.92  ? 346 GLN A CB  1 
ATOM   2512 C CG  . GLN A 1 318 ? 148.482 137.248 105.691 1.00 4.92  ? 346 GLN A CG  1 
ATOM   2513 C CD  . GLN A 1 318 ? 148.994 136.785 104.348 1.00 4.92  ? 346 GLN A CD  1 
ATOM   2514 O OE1 . GLN A 1 318 ? 148.760 135.649 103.942 1.00 4.92  ? 346 GLN A OE1 1 
ATOM   2515 N NE2 . GLN A 1 318 ? 149.699 137.664 103.649 1.00 4.92  ? 346 GLN A NE2 1 
ATOM   2516 N N   . ILE A 1 319 ? 145.362 134.920 108.165 1.00 4.06  ? 347 ILE A N   1 
ATOM   2517 C CA  . ILE A 1 319 ? 143.995 134.757 108.652 1.00 4.06  ? 347 ILE A CA  1 
ATOM   2518 C C   . ILE A 1 319 ? 143.945 134.936 110.166 1.00 4.06  ? 347 ILE A C   1 
ATOM   2519 O O   . ILE A 1 319 ? 142.964 135.471 110.700 1.00 4.06  ? 347 ILE A O   1 
ATOM   2520 C CB  . ILE A 1 319 ? 143.391 133.413 108.203 1.00 4.06  ? 347 ILE A CB  1 
ATOM   2521 C CG1 . ILE A 1 319 ? 143.938 132.246 109.015 1.00 4.06  ? 347 ILE A CG1 1 
ATOM   2522 C CG2 . ILE A 1 319 ? 143.648 133.182 106.736 1.00 4.06  ? 347 ILE A CG2 1 
ATOM   2523 C CD1 . ILE A 1 319 ? 143.351 130.921 108.618 1.00 4.06  ? 347 ILE A CD1 1 
ATOM   2524 N N   . VAL A 1 320 ? 145.004 134.538 110.883 1.00 3.39  ? 348 VAL A N   1 
ATOM   2525 C CA  . VAL A 1 320 ? 145.032 134.754 112.327 1.00 3.39  ? 348 VAL A CA  1 
ATOM   2526 C C   . VAL A 1 320 ? 145.086 136.242 112.653 1.00 3.39  ? 348 VAL A C   1 
ATOM   2527 O O   . VAL A 1 320 ? 144.394 136.716 113.564 1.00 3.39  ? 348 VAL A O   1 
ATOM   2528 C CB  . VAL A 1 320 ? 146.212 133.996 112.956 1.00 3.39  ? 348 VAL A CB  1 
ATOM   2529 C CG1 . VAL A 1 320 ? 146.455 134.495 114.352 1.00 3.39  ? 348 VAL A CG1 1 
ATOM   2530 C CG2 . VAL A 1 320 ? 145.930 132.511 112.979 1.00 3.39  ? 348 VAL A CG2 1 
ATOM   2531 N N   . ASP A 1 321 ? 145.915 136.999 111.928 1.00 4.98  ? 349 ASP A N   1 
ATOM   2532 C CA  . ASP A 1 321 ? 145.995 138.443 112.140 1.00 4.98  ? 349 ASP A CA  1 
ATOM   2533 C C   . ASP A 1 321 ? 144.644 139.102 111.919 1.00 4.98  ? 349 ASP A C   1 
ATOM   2534 O O   . ASP A 1 321 ? 144.203 139.935 112.722 1.00 4.98  ? 349 ASP A O   1 
ATOM   2535 C CB  . ASP A 1 321 ? 147.032 139.059 111.202 1.00 4.98  ? 349 ASP A CB  1 
ATOM   2536 C CG  . ASP A 1 321 ? 148.393 139.192 111.841 1.00 4.98  ? 349 ASP A CG  1 
ATOM   2537 O OD1 . ASP A 1 321 ? 148.457 139.434 113.064 1.00 4.98  ? 349 ASP A OD1 1 
ATOM   2538 O OD2 . ASP A 1 321 ? 149.401 139.063 111.117 1.00 4.98  ? 349 ASP A OD2 1 
ATOM   2539 N N   . LYS A 1 322 ? 143.974 138.746 110.822 1.00 3.95  ? 350 LYS A N   1 
ATOM   2540 C CA  . LYS A 1 322 ? 142.667 139.332 110.546 1.00 3.95  ? 350 LYS A CA  1 
ATOM   2541 C C   . LYS A 1 322 ? 141.659 138.965 111.628 1.00 3.95  ? 350 LYS A C   1 
ATOM   2542 O O   . LYS A 1 322 ? 140.863 139.811 112.053 1.00 3.95  ? 350 LYS A O   1 
ATOM   2543 C CB  . LYS A 1 322 ? 142.176 138.894 109.169 1.00 3.95  ? 350 LYS A CB  1 
ATOM   2544 C CG  . LYS A 1 322 ? 142.771 139.696 108.027 1.00 3.95  ? 350 LYS A CG  1 
ATOM   2545 C CD  . LYS A 1 322 ? 142.526 139.022 106.696 1.00 3.95  ? 350 LYS A CD  1 
ATOM   2546 C CE  . LYS A 1 322 ? 143.782 138.363 106.180 1.00 3.95  ? 350 LYS A CE  1 
ATOM   2547 N NZ  . LYS A 1 322 ? 144.707 139.368 105.602 1.00 3.95  ? 350 LYS A NZ  1 
ATOM   2548 N N   . THR A 1 323 ? 141.687 137.714 112.099 1.00 3.69  ? 351 THR A N   1 
ATOM   2549 C CA  . THR A 1 323 ? 140.778 137.305 113.167 1.00 3.69  ? 351 THR A CA  1 
ATOM   2550 C C   . THR A 1 323 ? 141.005 138.124 114.430 1.00 3.69  ? 351 THR A C   1 
ATOM   2551 O O   . THR A 1 323 ? 140.054 138.626 115.041 1.00 3.69  ? 351 THR A O   1 
ATOM   2552 C CB  . THR A 1 323 ? 140.956 135.819 113.468 1.00 3.69  ? 351 THR A CB  1 
ATOM   2553 O OG1 . THR A 1 323 ? 140.407 135.044 112.397 1.00 3.69  ? 351 THR A OG1 1 
ATOM   2554 C CG2 . THR A 1 323 ? 140.250 135.457 114.761 1.00 3.69  ? 351 THR A CG2 1 
ATOM   2555 N N   . ILE A 1 324 ? 142.268 138.274 114.834 1.00 4.17  ? 352 ILE A N   1 
ATOM   2556 C CA  . ILE A 1 324 ? 142.570 138.990 116.072 1.00 4.17  ? 352 ILE A CA  1 
ATOM   2557 C C   . ILE A 1 324 ? 142.176 140.456 115.952 1.00 4.17  ? 352 ILE A C   1 
ATOM   2558 O O   . ILE A 1 324 ? 141.610 141.037 116.887 1.00 4.17  ? 352 ILE A O   1 
ATOM   2559 C CB  . ILE A 1 324 ? 144.054 138.818 116.444 1.00 4.17  ? 352 ILE A CB  1 
ATOM   2560 C CG1 . ILE A 1 324 ? 144.247 137.514 117.218 1.00 4.17  ? 352 ILE A CG1 1 
ATOM   2561 C CG2 . ILE A 1 324 ? 144.547 139.995 117.256 1.00 4.17  ? 352 ILE A CG2 1 
ATOM   2562 C CD1 . ILE A 1 324 ? 145.688 137.139 117.446 1.00 4.17  ? 352 ILE A CD1 1 
ATOM   2563 N N   . ILE A 1 325 ? 142.449 141.077 114.799 1.00 4.54  ? 353 ILE A N   1 
ATOM   2564 C CA  . ILE A 1 325 ? 142.050 142.471 114.605 1.00 4.54  ? 353 ILE A CA  1 
ATOM   2565 C C   . ILE A 1 325 ? 140.533 142.606 114.636 1.00 4.54  ? 353 ILE A C   1 
ATOM   2566 O O   . ILE A 1 325 ? 139.993 143.584 115.167 1.00 4.54  ? 353 ILE A O   1 
ATOM   2567 C CB  . ILE A 1 325 ? 142.646 143.032 113.301 1.00 4.54  ? 353 ILE A CB  1 
ATOM   2568 C CG1 . ILE A 1 325 ? 144.161 143.174 113.422 1.00 4.54  ? 353 ILE A CG1 1 
ATOM   2569 C CG2 . ILE A 1 325 ? 142.027 144.369 112.955 1.00 4.54  ? 353 ILE A CG2 1 
ATOM   2570 C CD1 . ILE A 1 325 ? 144.827 143.574 112.132 1.00 4.54  ? 353 ILE A CD1 1 
ATOM   2571 N N   . ASN A 1 326 ? 139.818 141.629 114.077 1.00 5.08  ? 354 ASN A N   1 
ATOM   2572 C CA  . ASN A 1 326 ? 138.363 141.653 114.152 1.00 5.08  ? 354 ASN A CA  1 
ATOM   2573 C C   . ASN A 1 326 ? 137.836 141.299 115.537 1.00 5.08  ? 354 ASN A C   1 
ATOM   2574 O O   . ASN A 1 326 ? 136.641 141.487 115.789 1.00 5.08  ? 354 ASN A O   1 
ATOM   2575 C CB  . ASN A 1 326 ? 137.769 140.702 113.113 1.00 5.08  ? 354 ASN A CB  1 
ATOM   2576 C CG  . ASN A 1 326 ? 137.434 141.399 111.808 1.00 5.08  ? 354 ASN A CG  1 
ATOM   2577 O OD1 . ASN A 1 326 ? 136.626 142.326 111.777 1.00 5.08  ? 354 ASN A OD1 1 
ATOM   2578 N ND2 . ASN A 1 326 ? 138.064 140.962 110.725 1.00 5.08  ? 354 ASN A ND2 1 
ATOM   2579 N N   . ALA A 1 327 ? 138.684 140.794 116.433 1.00 4.53  ? 355 ALA A N   1 
ATOM   2580 C CA  . ALA A 1 327 ? 138.257 140.443 117.782 1.00 4.53  ? 355 ALA A CA  1 
ATOM   2581 C C   . ALA A 1 327 ? 138.623 141.481 118.833 1.00 4.53  ? 355 ALA A C   1 
ATOM   2582 O O   . ALA A 1 327 ? 137.964 141.542 119.875 1.00 4.53  ? 355 ALA A O   1 
ATOM   2583 C CB  . ALA A 1 327 ? 138.852 139.094 118.192 1.00 4.53  ? 355 ALA A CB  1 
ATOM   2584 N N   . ASP A 1 328 ? 139.650 142.298 118.594 1.00 5.69  ? 356 ASP A N   1 
ATOM   2585 C CA  . ASP A 1 328 ? 140.082 143.301 119.565 1.00 5.69  ? 356 ASP A CA  1 
ATOM   2586 C C   . ASP A 1 328 ? 139.008 144.369 119.724 1.00 5.69  ? 356 ASP A C   1 
ATOM   2587 O O   . ASP A 1 328 ? 138.833 145.219 118.846 1.00 5.69  ? 356 ASP A O   1 
ATOM   2588 C CB  . ASP A 1 328 ? 141.398 143.937 119.128 1.00 5.69  ? 356 ASP A CB  1 
ATOM   2589 C CG  . ASP A 1 328 ? 142.608 143.176 119.618 1.00 5.69  ? 356 ASP A CG  1 
ATOM   2590 O OD1 . ASP A 1 328 ? 142.502 142.492 120.657 1.00 5.69  ? 356 ASP A OD1 1 
ATOM   2591 O OD2 . ASP A 1 328 ? 143.672 143.275 118.973 1.00 5.69  ? 356 ASP A OD2 1 
ATOM   2592 N N   . LYS A 1 329 ? 138.294 144.337 120.845 1.00 8.19  ? 357 LYS A N   1 
ATOM   2593 C CA  . LYS A 1 329 ? 137.318 145.366 121.170 1.00 8.19  ? 357 LYS A CA  1 
ATOM   2594 C C   . LYS A 1 329 ? 137.886 146.461 122.064 1.00 8.19  ? 357 LYS A C   1 
ATOM   2595 O O   . LYS A 1 329 ? 137.163 147.403 122.400 1.00 8.19  ? 357 LYS A O   1 
ATOM   2596 C CB  . LYS A 1 329 ? 136.091 144.739 121.841 1.00 8.19  ? 357 LYS A CB  1 
ATOM   2597 C CG  . LYS A 1 329 ? 135.364 143.693 121.005 1.00 8.19  ? 357 LYS A CG  1 
ATOM   2598 C CD  . LYS A 1 329 ? 134.578 144.306 119.848 1.00 8.19  ? 357 LYS A CD  1 
ATOM   2599 C CE  . LYS A 1 329 ? 135.322 144.186 118.522 1.00 8.19  ? 357 LYS A CE  1 
ATOM   2600 N NZ  . LYS A 1 329 ? 134.503 144.651 117.368 1.00 8.19  ? 357 LYS A NZ  1 
ATOM   2601 N N   . ASP A 1 330 ? 139.156 146.361 122.459 1.00 11.05 ? 358 ASP A N   1 
ATOM   2602 C CA  . ASP A 1 330 ? 139.778 147.362 123.317 1.00 11.05 ? 358 ASP A CA  1 
ATOM   2603 C C   . ASP A 1 330 ? 141.149 147.828 122.851 1.00 11.05 ? 358 ASP A C   1 
ATOM   2604 O O   . ASP A 1 330 ? 141.576 148.912 123.263 1.00 11.05 ? 358 ASP A O   1 
ATOM   2605 C CB  . ASP A 1 330 ? 139.901 146.837 124.756 1.00 11.05 ? 358 ASP A CB  1 
ATOM   2606 C CG  . ASP A 1 330 ? 140.746 145.583 124.852 1.00 11.05 ? 358 ASP A CG  1 
ATOM   2607 O OD1 . ASP A 1 330 ? 141.154 145.048 123.801 1.00 11.05 ? 358 ASP A OD1 1 
ATOM   2608 O OD2 . ASP A 1 330 ? 141.001 145.128 125.986 1.00 11.05 ? 358 ASP A OD2 1 
ATOM   2609 N N   . GLY A 1 331 ? 141.849 147.064 122.021 1.00 9.46  ? 359 GLY A N   1 
ATOM   2610 C CA  . GLY A 1 331 ? 143.138 147.474 121.507 1.00 9.46  ? 359 GLY A CA  1 
ATOM   2611 C C   . GLY A 1 331 ? 144.344 146.856 122.176 1.00 9.46  ? 359 GLY A C   1 
ATOM   2612 O O   . GLY A 1 331 ? 145.471 147.246 121.854 1.00 9.46  ? 359 GLY A O   1 
ATOM   2613 N N   . ASP A 1 332 ? 144.148 145.911 123.097 1.00 8.46  ? 360 ASP A N   1 
ATOM   2614 C CA  . ASP A 1 332 ? 145.284 145.274 123.755 1.00 8.46  ? 360 ASP A CA  1 
ATOM   2615 C C   . ASP A 1 332 ? 146.123 144.477 122.766 1.00 8.46  ? 360 ASP A C   1 
ATOM   2616 O O   . ASP A 1 332 ? 147.358 144.500 122.827 1.00 8.46  ? 360 ASP A O   1 
ATOM   2617 C CB  . ASP A 1 332 ? 144.792 144.373 124.887 1.00 8.46  ? 360 ASP A CB  1 
ATOM   2618 C CG  . ASP A 1 332 ? 145.920 143.869 125.768 1.00 8.46  ? 360 ASP A CG  1 
ATOM   2619 O OD1 . ASP A 1 332 ? 145.665 142.984 126.611 1.00 8.46  ? 360 ASP A OD1 1 
ATOM   2620 O OD2 . ASP A 1 332 ? 147.059 144.360 125.624 1.00 8.46  ? 360 ASP A OD2 1 
ATOM   2621 N N   . GLY A 1 333 ? 145.474 143.776 121.843 1.00 7.36  ? 361 GLY A N   1 
ATOM   2622 C CA  . GLY A 1 333 ? 146.149 142.847 120.961 1.00 7.36  ? 361 GLY A CA  1 
ATOM   2623 C C   . GLY A 1 333 ? 145.976 141.389 121.319 1.00 7.36  ? 361 GLY A C   1 
ATOM   2624 O O   . GLY A 1 333 ? 146.641 140.539 120.718 1.00 7.36  ? 361 GLY A O   1 
ATOM   2625 N N   . ARG A 1 334 ? 145.127 141.079 122.296 1.00 4.24  ? 362 ARG A N   1 
ATOM   2626 C CA  . ARG A 1 334 ? 144.842 139.714 122.706 1.00 4.24  ? 362 ARG A CA  1 
ATOM   2627 C C   . ARG A 1 334 ? 143.355 139.611 123.009 1.00 4.24  ? 362 ARG A C   1 
ATOM   2628 O O   . ARG A 1 334 ? 142.675 140.619 123.217 1.00 4.24  ? 362 ARG A O   1 
ATOM   2629 C CB  . ARG A 1 334 ? 145.676 139.297 123.929 1.00 4.24  ? 362 ARG A CB  1 
ATOM   2630 C CG  . ARG A 1 334 ? 147.022 140.008 124.050 1.00 4.24  ? 362 ARG A CG  1 
ATOM   2631 C CD  . ARG A 1 334 ? 148.066 139.172 124.776 1.00 4.24  ? 362 ARG A CD  1 
ATOM   2632 N NE  . ARG A 1 334 ? 147.840 139.103 126.217 1.00 4.24  ? 362 ARG A NE  1 
ATOM   2633 C CZ  . ARG A 1 334 ? 148.691 138.550 127.074 1.00 4.24  ? 362 ARG A CZ  1 
ATOM   2634 N NH1 . ARG A 1 334 ? 149.824 138.021 126.636 1.00 4.24  ? 362 ARG A NH1 1 
ATOM   2635 N NH2 . ARG A 1 334 ? 148.413 138.526 128.369 1.00 4.24  ? 362 ARG A NH2 1 
ATOM   2636 N N   . ILE A 1 335 ? 142.849 138.380 123.026 1.00 3.84  ? 363 ILE A N   1 
ATOM   2637 C CA  . ILE A 1 335 ? 141.426 138.116 123.220 1.00 3.84  ? 363 ILE A CA  1 
ATOM   2638 C C   . ILE A 1 335 ? 141.203 137.598 124.634 1.00 3.84  ? 363 ILE A C   1 
ATOM   2639 O O   . ILE A 1 335 ? 141.873 136.656 125.073 1.00 3.84  ? 363 ILE A O   1 
ATOM   2640 C CB  . ILE A 1 335 ? 140.894 137.115 122.180 1.00 3.84  ? 363 ILE A CB  1 
ATOM   2641 C CG1 . ILE A 1 335 ? 141.143 137.625 120.765 1.00 3.84  ? 363 ILE A CG1 1 
ATOM   2642 C CG2 . ILE A 1 335 ? 139.412 136.882 122.376 1.00 3.84  ? 363 ILE A CG2 1 
ATOM   2643 C CD1 . ILE A 1 335 ? 142.257 136.912 120.062 1.00 3.84  ? 363 ILE A CD1 1 
ATOM   2644 N N   . SER A 1 336 ? 140.267 138.216 125.346 1.00 4.80  ? 364 SER A N   1 
ATOM   2645 C CA  . SER A 1 336 ? 139.859 137.761 126.665 1.00 4.80  ? 364 SER A CA  1 
ATOM   2646 C C   . SER A 1 336 ? 138.698 136.784 126.514 1.00 4.80  ? 364 SER A C   1 
ATOM   2647 O O   . SER A 1 336 ? 138.312 136.418 125.403 1.00 4.80  ? 364 SER A O   1 
ATOM   2648 C CB  . SER A 1 336 ? 139.476 138.946 127.544 1.00 4.80  ? 364 SER A CB  1 
ATOM   2649 O OG  . SER A 1 336 ? 138.149 139.359 127.272 1.00 4.80  ? 364 SER A OG  1 
ATOM   2650 N N   . PHE A 1 337 ? 138.119 136.352 127.633 1.00 6.95  ? 365 PHE A N   1 
ATOM   2651 C CA  . PHE A 1 337 ? 136.986 135.440 127.551 1.00 6.95  ? 365 PHE A CA  1 
ATOM   2652 C C   . PHE A 1 337 ? 135.699 136.153 127.161 1.00 6.95  ? 365 PHE A C   1 
ATOM   2653 O O   . PHE A 1 337 ? 134.823 135.539 126.543 1.00 6.95  ? 365 PHE A O   1 
ATOM   2654 C CB  . PHE A 1 337 ? 136.793 134.701 128.872 1.00 6.95  ? 365 PHE A CB  1 
ATOM   2655 C CG  . PHE A 1 337 ? 135.806 133.576 128.790 1.00 6.95  ? 365 PHE A CG  1 
ATOM   2656 C CD1 . PHE A 1 337 ? 136.137 132.397 128.152 1.00 6.95  ? 365 PHE A CD1 1 
ATOM   2657 C CD2 . PHE A 1 337 ? 134.550 133.697 129.352 1.00 6.95  ? 365 PHE A CD2 1 
ATOM   2658 C CE1 . PHE A 1 337 ? 135.232 131.359 128.074 1.00 6.95  ? 365 PHE A CE1 1 
ATOM   2659 C CE2 . PHE A 1 337 ? 133.644 132.660 129.282 1.00 6.95  ? 365 PHE A CE2 1 
ATOM   2660 C CZ  . PHE A 1 337 ? 133.984 131.492 128.638 1.00 6.95  ? 365 PHE A CZ  1 
ATOM   2661 N N   . GLU A 1 338 ? 135.559 137.434 127.504 1.00 6.95  ? 366 GLU A N   1 
ATOM   2662 C CA  . GLU A 1 338 ? 134.370 138.165 127.080 1.00 6.95  ? 366 GLU A CA  1 
ATOM   2663 C C   . GLU A 1 338 ? 134.393 138.430 125.580 1.00 6.95  ? 366 GLU A C   1 
ATOM   2664 O O   . GLU A 1 338 ? 133.363 138.311 124.906 1.00 6.95  ? 366 GLU A O   1 
ATOM   2665 C CB  . GLU A 1 338 ? 134.243 139.472 127.859 1.00 6.95  ? 366 GLU A CB  1 
ATOM   2666 C CG  . GLU A 1 338 ? 132.978 140.248 127.532 1.00 6.95  ? 366 GLU A CG  1 
ATOM   2667 C CD  . GLU A 1 338 ? 131.756 139.353 127.427 1.00 6.95  ? 366 GLU A CD  1 
ATOM   2668 O OE1 . GLU A 1 338 ? 131.500 138.573 128.370 1.00 6.95  ? 366 GLU A OE1 1 
ATOM   2669 O OE2 . GLU A 1 338 ? 131.053 139.425 126.397 1.00 6.95  ? 366 GLU A OE2 1 
ATOM   2670 N N   . GLU A 1 339 ? 135.560 138.780 125.035 1.00 6.45  ? 367 GLU A N   1 
ATOM   2671 C CA  . GLU A 1 339 ? 135.678 138.932 123.589 1.00 6.45  ? 367 GLU A CA  1 
ATOM   2672 C C   . GLU A 1 339 ? 135.450 137.601 122.882 1.00 6.45  ? 367 GLU A C   1 
ATOM   2673 O O   . GLU A 1 339 ? 134.832 137.553 121.812 1.00 6.45  ? 367 GLU A O   1 
ATOM   2674 C CB  . GLU A 1 339 ? 137.046 139.516 123.237 1.00 6.45  ? 367 GLU A CB  1 
ATOM   2675 C CG  . GLU A 1 339 ? 137.261 140.940 123.745 1.00 6.45  ? 367 GLU A CG  1 
ATOM   2676 C CD  . GLU A 1 339 ? 138.730 141.299 123.905 1.00 6.45  ? 367 GLU A CD  1 
ATOM   2677 O OE1 . GLU A 1 339 ? 139.461 140.539 124.571 1.00 6.45  ? 367 GLU A OE1 1 
ATOM   2678 O OE2 . GLU A 1 339 ? 139.154 142.342 123.367 1.00 6.45  ? 367 GLU A OE2 1 
ATOM   2679 N N   . PHE A 1 340 ? 135.933 136.508 123.474 1.00 7.93  ? 368 PHE A N   1 
ATOM   2680 C CA  . PHE A 1 340 ? 135.682 135.180 122.924 1.00 7.93  ? 368 PHE A CA  1 
ATOM   2681 C C   . PHE A 1 340 ? 134.190 134.867 122.897 1.00 7.93  ? 368 PHE A C   1 
ATOM   2682 O O   . PHE A 1 340 ? 133.671 134.364 121.896 1.00 7.93  ? 368 PHE A O   1 
ATOM   2683 C CB  . PHE A 1 340 ? 136.445 134.139 123.743 1.00 7.93  ? 368 PHE A CB  1 
ATOM   2684 C CG  . PHE A 1 340 ? 136.294 132.732 123.250 1.00 7.93  ? 368 PHE A CG  1 
ATOM   2685 C CD1 . PHE A 1 340 ? 137.231 132.181 122.403 1.00 7.93  ? 368 PHE A CD1 1 
ATOM   2686 C CD2 . PHE A 1 340 ? 135.233 131.948 123.664 1.00 7.93  ? 368 PHE A CD2 1 
ATOM   2687 C CE1 . PHE A 1 340 ? 137.102 130.881 121.963 1.00 7.93  ? 368 PHE A CE1 1 
ATOM   2688 C CE2 . PHE A 1 340 ? 135.100 130.651 123.225 1.00 7.93  ? 368 PHE A CE2 1 
ATOM   2689 C CZ  . PHE A 1 340 ? 136.033 130.117 122.375 1.00 7.93  ? 368 PHE A CZ  1 
ATOM   2690 N N   . CYS A 1 341 ? 133.481 135.156 123.992 1.00 6.78  ? 369 CYS A N   1 
ATOM   2691 C CA  . CYS A 1 341 ? 132.042 134.913 124.022 1.00 6.78  ? 369 CYS A CA  1 
ATOM   2692 C C   . CYS A 1 341 ? 131.270 135.858 123.113 1.00 6.78  ? 369 CYS A C   1 
ATOM   2693 O O   . CYS A 1 341 ? 130.142 135.541 122.724 1.00 6.78  ? 369 CYS A O   1 
ATOM   2694 C CB  . CYS A 1 341 ? 131.510 135.026 125.447 1.00 6.78  ? 369 CYS A CB  1 
ATOM   2695 S SG  . CYS A 1 341 ? 132.136 133.761 126.553 1.00 6.78  ? 369 CYS A SG  1 
ATOM   2696 N N   . ALA A 1 342 ? 131.831 137.024 122.797 1.00 7.84  ? 370 ALA A N   1 
ATOM   2697 C CA  . ALA A 1 342 ? 131.238 137.849 121.751 1.00 7.84  ? 370 ALA A CA  1 
ATOM   2698 C C   . ALA A 1 342 ? 131.441 137.214 120.382 1.00 7.84  ? 370 ALA A C   1 
ATOM   2699 O O   . ALA A 1 342 ? 130.542 137.246 119.534 1.00 7.84  ? 370 ALA A O   1 
ATOM   2700 C CB  . ALA A 1 342 ? 131.830 139.257 121.788 1.00 7.84  ? 370 ALA A CB  1 
ATOM   2701 N N   . VAL A 1 343 ? 132.615 136.623 120.155 1.00 6.84  ? 371 VAL A N   1 
ATOM   2702 C CA  . VAL A 1 343 ? 132.904 135.991 118.870 1.00 6.84  ? 371 VAL A CA  1 
ATOM   2703 C C   . VAL A 1 343 ? 132.163 134.665 118.741 1.00 6.84  ? 371 VAL A C   1 
ATOM   2704 O O   . VAL A 1 343 ? 131.450 134.427 117.759 1.00 6.84  ? 371 VAL A O   1 
ATOM   2705 C CB  . VAL A 1 343 ? 134.421 135.806 118.700 1.00 6.84  ? 371 VAL A CB  1 
ATOM   2706 C CG1 . VAL A 1 343 ? 134.713 135.035 117.445 1.00 6.84  ? 371 VAL A CG1 1 
ATOM   2707 C CG2 . VAL A 1 343 ? 135.105 137.156 118.646 1.00 6.84  ? 371 VAL A CG2 1 
ATOM   2708 N N   . VAL A 1 344 ? 132.321 133.785 119.723 1.00 6.75  ? 372 VAL A N   1 
ATOM   2709 C CA  . VAL A 1 344 ? 131.700 132.468 119.709 1.00 6.75  ? 372 VAL A CA  1 
ATOM   2710 C C   . VAL A 1 344 ? 130.606 132.437 120.766 1.00 6.75  ? 372 VAL A C   1 
ATOM   2711 O O   . VAL A 1 344 ? 130.688 133.118 121.792 1.00 6.75  ? 372 VAL A O   1 
ATOM   2712 C CB  . VAL A 1 344 ? 132.743 131.359 119.949 1.00 6.75  ? 372 VAL A CB  1 
ATOM   2713 C CG1 . VAL A 1 344 ? 132.111 129.995 119.825 1.00 6.75  ? 372 VAL A CG1 1 
ATOM   2714 C CG2 . VAL A 1 344 ? 133.882 131.502 118.970 1.00 6.75  ? 372 VAL A CG2 1 
ATOM   2715 N N   . GLY A 1 345 ? 129.590 131.616 120.528 1.00 8.36  ? 373 GLY A N   1 
ATOM   2716 C CA  . GLY A 1 345 ? 128.374 131.673 121.312 1.00 8.36  ? 373 GLY A CA  1 
ATOM   2717 C C   . GLY A 1 345 ? 127.200 131.956 120.405 1.00 8.36  ? 373 GLY A C   1 
ATOM   2718 O O   . GLY A 1 345 ? 127.055 133.061 119.873 1.00 8.36  ? 373 GLY A O   1 
ATOM   2719 N N   . GLY A 1 346 ? 126.352 130.949 120.225 1.00 10.77 ? 374 GLY A N   1 
ATOM   2720 C CA  . GLY A 1 346 ? 125.401 130.895 119.138 1.00 10.77 ? 374 GLY A CA  1 
ATOM   2721 C C   . GLY A 1 346 ? 125.729 129.824 118.124 1.00 10.77 ? 374 GLY A C   1 
ATOM   2722 O O   . GLY A 1 346 ? 124.840 129.398 117.375 1.00 10.77 ? 374 GLY A O   1 
ATOM   2723 N N   . LEU A 1 347 ? 126.986 129.381 118.080 1.00 11.43 ? 375 LEU A N   1 
ATOM   2724 C CA  . LEU A 1 347 ? 127.360 128.180 117.348 1.00 11.43 ? 375 LEU A CA  1 
ATOM   2725 C C   . LEU A 1 347 ? 126.808 126.919 117.993 1.00 11.43 ? 375 LEU A C   1 
ATOM   2726 O O   . LEU A 1 347 ? 126.860 125.853 117.369 1.00 11.43 ? 375 LEU A O   1 
ATOM   2727 C CB  . LEU A 1 347 ? 128.882 128.072 117.256 1.00 11.43 ? 375 LEU A CB  1 
ATOM   2728 C CG  . LEU A 1 347 ? 129.591 128.693 116.055 1.00 11.43 ? 375 LEU A CG  1 
ATOM   2729 C CD1 . LEU A 1 347 ? 129.487 130.207 116.084 1.00 11.43 ? 375 LEU A CD1 1 
ATOM   2730 C CD2 . LEU A 1 347 ? 131.041 128.255 116.042 1.00 11.43 ? 375 LEU A CD2 1 
ATOM   2731 N N   . ASP A 1 348 ? 126.299 127.017 119.222 1.00 13.33 ? 376 ASP A N   1 
ATOM   2732 C CA  . ASP A 1 348 ? 125.758 125.884 119.969 1.00 13.33 ? 376 ASP A CA  1 
ATOM   2733 C C   . ASP A 1 348 ? 126.826 124.807 120.175 1.00 13.33 ? 376 ASP A C   1 
ATOM   2734 O O   . ASP A 1 348 ? 126.670 123.649 119.786 1.00 13.33 ? 376 ASP A O   1 
ATOM   2735 C CB  . ASP A 1 348 ? 124.516 125.313 119.278 1.00 13.33 ? 376 ASP A CB  1 
ATOM   2736 C CG  . ASP A 1 348 ? 123.526 124.730 120.259 1.00 13.33 ? 376 ASP A CG  1 
ATOM   2737 O OD1 . ASP A 1 348 ? 122.342 124.571 119.893 1.00 13.33 ? 376 ASP A OD1 1 
ATOM   2738 O OD2 . ASP A 1 348 ? 123.935 124.435 121.400 1.00 13.33 ? 376 ASP A OD2 1 
ATOM   2739 N N   . ILE A 1 349 ? 127.929 125.221 120.801 1.00 14.63 ? 377 ILE A N   1 
ATOM   2740 C CA  . ILE A 1 349 ? 129.014 124.296 121.107 1.00 14.63 ? 377 ILE A CA  1 
ATOM   2741 C C   . ILE A 1 349 ? 128.825 123.592 122.448 1.00 14.63 ? 377 ILE A C   1 
ATOM   2742 O O   . ILE A 1 349 ? 129.433 122.535 122.674 1.00 14.63 ? 377 ILE A O   1 
ATOM   2743 C CB  . ILE A 1 349 ? 130.371 125.023 121.070 1.00 14.63 ? 377 ILE A CB  1 
ATOM   2744 C CG1 . ILE A 1 349 ? 131.519 124.014 120.995 1.00 14.63 ? 377 ILE A CG1 1 
ATOM   2745 C CG2 . ILE A 1 349 ? 130.525 125.942 122.270 1.00 14.63 ? 377 ILE A CG2 1 
ATOM   2746 C CD1 . ILE A 1 349 ? 131.420 123.068 119.822 1.00 14.63 ? 377 ILE A CD1 1 
ATOM   2747 N N   . HIS A 1 350 ? 127.989 124.133 123.336 1.00 14.65 ? 378 HIS A N   1 
ATOM   2748 C CA  . HIS A 1 350 ? 127.731 123.467 124.606 1.00 14.65 ? 378 HIS A CA  1 
ATOM   2749 C C   . HIS A 1 350 ? 126.978 122.155 124.430 1.00 14.65 ? 378 HIS A C   1 
ATOM   2750 O O   . HIS A 1 350 ? 127.025 121.304 125.323 1.00 14.65 ? 378 HIS A O   1 
ATOM   2751 C CB  . HIS A 1 350 ? 126.953 124.393 125.538 1.00 14.65 ? 378 HIS A CB  1 
ATOM   2752 C CG  . HIS A 1 350 ? 125.520 124.580 125.149 1.00 14.65 ? 378 HIS A CG  1 
ATOM   2753 N ND1 . HIS A 1 350 ? 125.092 125.629 124.365 1.00 14.65 ? 378 HIS A ND1 1 
ATOM   2754 C CD2 . HIS A 1 350 ? 124.414 123.856 125.444 1.00 14.65 ? 378 HIS A CD2 1 
ATOM   2755 C CE1 . HIS A 1 350 ? 123.785 125.542 124.191 1.00 14.65 ? 378 HIS A CE1 1 
ATOM   2756 N NE2 . HIS A 1 350 ? 123.350 124.474 124.835 1.00 14.65 ? 378 HIS A NE2 1 
ATOM   2757 N N   . LYS A 1 351 ? 126.288 121.971 123.307 1.00 12.76 ? 379 LYS A N   1 
ATOM   2758 C CA  . LYS A 1 351 ? 125.563 120.738 123.035 1.00 12.76 ? 379 LYS A CA  1 
ATOM   2759 C C   . LYS A 1 351 ? 126.427 119.672 122.377 1.00 12.76 ? 379 LYS A C   1 
ATOM   2760 O O   . LYS A 1 351 ? 125.950 118.552 122.173 1.00 12.76 ? 379 LYS A O   1 
ATOM   2761 C CB  . LYS A 1 351 ? 124.347 121.022 122.147 1.00 12.76 ? 379 LYS A CB  1 
ATOM   2762 C CG  . LYS A 1 351 ? 123.168 121.636 122.881 1.00 12.76 ? 379 LYS A CG  1 
ATOM   2763 C CD  . LYS A 1 351 ? 122.031 121.961 121.925 1.00 12.76 ? 379 LYS A CD  1 
ATOM   2764 C CE  . LYS A 1 351 ? 121.016 120.834 121.861 1.00 12.76 ? 379 LYS A CE  1 
ATOM   2765 N NZ  . LYS A 1 351 ? 119.622 121.353 121.930 1.00 12.76 ? 379 LYS A NZ  1 
ATOM   2766 N N   . LYS A 1 352 ? 127.677 119.986 122.039 1.00 12.21 ? 380 LYS A N   1 
ATOM   2767 C CA  . LYS A 1 352 ? 128.547 119.029 121.370 1.00 12.21 ? 380 LYS A CA  1 
ATOM   2768 C C   . LYS A 1 352 ? 129.539 118.353 122.305 1.00 12.21 ? 380 LYS A C   1 
ATOM   2769 O O   . LYS A 1 352 ? 129.954 117.223 122.026 1.00 12.21 ? 380 LYS A O   1 
ATOM   2770 C CB  . LYS A 1 352 ? 129.312 119.712 120.230 1.00 12.21 ? 380 LYS A CB  1 
ATOM   2771 C CG  . LYS A 1 352 ? 129.925 118.742 119.234 1.00 12.21 ? 380 LYS A CG  1 
ATOM   2772 C CD  . LYS A 1 352 ? 130.274 119.431 117.927 1.00 12.21 ? 380 LYS A CD  1 
ATOM   2773 C CE  . LYS A 1 352 ? 129.109 119.396 116.958 1.00 12.21 ? 380 LYS A CE  1 
ATOM   2774 N NZ  . LYS A 1 352 ? 128.813 118.008 116.512 1.00 12.21 ? 380 LYS A NZ  1 
ATOM   2775 N N   . MET A 1 353 ? 129.926 119.006 123.401 1.00 11.97 ? 381 MET A N   1 
ATOM   2776 C CA  . MET A 1 353 ? 130.819 118.406 124.393 1.00 11.97 ? 381 MET A CA  1 
ATOM   2777 C C   . MET A 1 353 ? 129.949 117.743 125.451 1.00 11.97 ? 381 MET A C   1 
ATOM   2778 O O   . MET A 1 353 ? 129.613 118.337 126.475 1.00 11.97 ? 381 MET A O   1 
ATOM   2779 C CB  . MET A 1 353 ? 131.745 119.458 124.990 1.00 11.97 ? 381 MET A CB  1 
ATOM   2780 C CG  . MET A 1 353 ? 132.915 119.817 124.094 1.00 11.97 ? 381 MET A CG  1 
ATOM   2781 S SD  . MET A 1 353 ? 134.229 120.708 124.940 1.00 11.97 ? 381 MET A SD  1 
ATOM   2782 C CE  . MET A 1 353 ? 134.303 122.197 123.954 1.00 11.97 ? 381 MET A CE  1 
ATOM   2783 N N   . VAL A 1 354 ? 129.576 116.492 125.198 1.00 10.09 ? 382 VAL A N   1 
ATOM   2784 C CA  . VAL A 1 354 ? 128.624 115.770 126.030 1.00 10.09 ? 382 VAL A CA  1 
ATOM   2785 C C   . VAL A 1 354 ? 129.198 114.406 126.381 1.00 10.09 ? 382 VAL A C   1 
ATOM   2786 O O   . VAL A 1 354 ? 129.752 113.712 125.522 1.00 10.09 ? 382 VAL A O   1 
ATOM   2787 C CB  . VAL A 1 354 ? 127.256 115.629 125.328 1.00 10.09 ? 382 VAL A CB  1 
ATOM   2788 C CG1 . VAL A 1 354 ? 127.415 114.986 123.955 1.00 10.09 ? 382 VAL A CG1 1 
ATOM   2789 C CG2 . VAL A 1 354 ? 126.287 114.832 126.189 1.00 10.09 ? 382 VAL A CG2 1 
ATOM   2790 N N   . VAL A 1 355 ? 129.083 114.031 127.655 1.00 8.39  ? 383 VAL A N   1 
ATOM   2791 C CA  . VAL A 1 355 ? 129.480 112.717 128.135 1.00 8.39  ? 383 VAL A CA  1 
ATOM   2792 C C   . VAL A 1 355 ? 128.341 112.197 129.006 1.00 8.39  ? 383 VAL A C   1 
ATOM   2793 O O   . VAL A 1 355 ? 127.511 112.962 129.501 1.00 8.39  ? 383 VAL A O   1 
ATOM   2794 C CB  . VAL A 1 355 ? 130.819 112.766 128.912 1.00 8.39  ? 383 VAL A CB  1 
ATOM   2795 C CG1 . VAL A 1 355 ? 131.243 111.389 129.400 1.00 8.39  ? 383 VAL A CG1 1 
ATOM   2796 C CG2 . VAL A 1 355 ? 131.912 113.379 128.056 1.00 8.39  ? 383 VAL A CG2 1 
ATOM   2797 N N   . ASP A 1 356 ? 128.293 110.874 129.175 1.00 7.99  ? 384 ASP A N   1 
ATOM   2798 C CA  . ASP A 1 356 ? 127.204 110.228 129.899 1.00 7.99  ? 384 ASP A CA  1 
ATOM   2799 C C   . ASP A 1 356 ? 127.266 110.428 131.410 1.00 7.99  ? 384 ASP A C   1 
ATOM   2800 O O   . ASP A 1 356 ? 126.302 110.071 132.095 1.00 7.99  ? 384 ASP A O   1 
ATOM   2801 C CB  . ASP A 1 356 ? 127.196 108.731 129.586 1.00 7.99  ? 384 ASP A CB  1 
ATOM   2802 C CG  . ASP A 1 356 ? 125.934 108.043 130.062 1.00 7.99  ? 384 ASP A CG  1 
ATOM   2803 O OD1 . ASP A 1 356 ? 126.027 106.893 130.537 1.00 7.99  ? 384 ASP A OD1 1 
ATOM   2804 O OD2 . ASP A 1 356 ? 124.851 108.658 129.971 1.00 7.99  ? 384 ASP A OD2 1 
ATOM   2805 N N   . VAL A 1 357 ? 128.356 110.988 131.945 1.00 6.60  ? 385 VAL A N   1 
ATOM   2806 C CA  . VAL A 1 357 ? 128.526 111.053 133.393 1.00 6.60  ? 385 VAL A CA  1 
ATOM   2807 C C   . VAL A 1 357 ? 127.396 111.848 134.029 1.00 6.60  ? 385 VAL A C   1 
ATOM   2808 O O   . VAL A 1 357 ? 126.867 112.801 133.443 1.00 6.60  ? 385 VAL A O   1 
ATOM   2809 C CB  . VAL A 1 357 ? 129.893 111.657 133.746 1.00 6.60  ? 385 VAL A CB  1 
ATOM   2810 C CG1 . VAL A 1 357 ? 130.996 110.772 133.223 1.00 6.60  ? 385 VAL A CG1 1 
ATOM   2811 C CG2 . VAL A 1 357 ? 130.016 113.056 133.181 1.00 6.60  ? 385 VAL A CG2 1 
ATOM   2812 N N   . LYS A 1 358 ? 127.012 111.447 135.244 1.00 8.34  ? 386 LYS A N   1 
ATOM   2813 C CA  . LYS A 1 358 ? 125.874 112.036 135.940 1.00 8.34  ? 386 LYS A CA  1 
ATOM   2814 C C   . LYS A 1 358 ? 126.249 112.604 137.305 1.00 8.34  ? 386 LYS A C   1 
ATOM   2815 O O   . LYS A 1 358 ? 125.372 112.776 138.158 1.00 8.34  ? 386 LYS A O   1 
ATOM   2816 C CB  . LYS A 1 358 ? 124.754 111.007 136.094 1.00 8.34  ? 386 LYS A CB  1 
ATOM   2817 C CG  . LYS A 1 358 ? 123.966 110.750 134.825 1.00 8.34  ? 386 LYS A CG  1 
ATOM   2818 C CD  . LYS A 1 358 ? 122.900 109.692 135.054 1.00 8.34  ? 386 LYS A CD  1 
ATOM   2819 C CE  . LYS A 1 358 ? 121.831 110.189 136.012 1.00 8.34  ? 386 LYS A CE  1 
ATOM   2820 N NZ  . LYS A 1 358 ? 120.734 109.197 136.188 1.00 8.34  ? 386 LYS A NZ  1 
ATOM   2821 N N   . PHE A 1 359 ? 127.523 112.903 137.537 1.00 6.79  ? 387 PHE A N   1 
ATOM   2822 C CA  . PHE A 1 359 ? 127.964 113.495 138.791 1.00 6.79  ? 387 PHE A CA  1 
ATOM   2823 C C   . PHE A 1 359 ? 128.494 114.899 138.536 1.00 6.79  ? 387 PHE A C   1 
ATOM   2824 O O   . PHE A 1 359 ? 129.317 115.104 137.638 1.00 6.79  ? 387 PHE A O   1 
ATOM   2825 C CB  . PHE A 1 359 ? 129.024 112.626 139.476 1.00 6.79  ? 387 PHE A CB  1 
ATOM   2826 C CG  . PHE A 1 359 ? 130.306 112.476 138.700 1.00 6.79  ? 387 PHE A CG  1 
ATOM   2827 C CD1 . PHE A 1 359 ? 130.447 111.481 137.753 1.00 6.79  ? 387 PHE A CD1 1 
ATOM   2828 C CD2 . PHE A 1 359 ? 131.384 113.307 138.948 1.00 6.79  ? 387 PHE A CD2 1 
ATOM   2829 C CE1 . PHE A 1 359 ? 131.630 111.333 137.054 1.00 6.79  ? 387 PHE A CE1 1 
ATOM   2830 C CE2 . PHE A 1 359 ? 132.565 113.164 138.250 1.00 6.79  ? 387 PHE A CE2 1 
ATOM   2831 C CZ  . PHE A 1 359 ? 132.688 112.177 137.305 1.00 6.79  ? 387 PHE A CZ  1 
ATOM   2832 N N   . CYS A 1 360 ? 128.008 115.863 139.314 1.00 6.36  ? 388 CYS A N   1 
ATOM   2833 C CA  . CYS A 1 360 ? 128.447 117.250 139.230 1.00 6.36  ? 388 CYS A CA  1 
ATOM   2834 C C   . CYS A 1 360 ? 129.154 117.620 140.528 1.00 6.36  ? 388 CYS A C   1 
ATOM   2835 O O   . CYS A 1 360 ? 128.576 117.493 141.612 1.00 6.36  ? 388 CYS A O   1 
ATOM   2836 C CB  . CYS A 1 360 ? 127.269 118.187 138.970 1.00 6.36  ? 388 CYS A CB  1 
ATOM   2837 S SG  . CYS A 1 360 ? 127.745 119.865 138.503 1.00 6.36  ? 388 CYS A SG  1 
ATOM   2838 N N   . LEU A 1 361 ? 130.398 118.074 140.413 1.00 4.65  ? 389 LEU A N   1 
ATOM   2839 C CA  . LEU A 1 361 ? 131.247 118.405 141.549 1.00 4.65  ? 389 LEU A CA  1 
ATOM   2840 C C   . LEU A 1 361 ? 131.828 119.800 141.389 1.00 4.65  ? 389 LEU A C   1 
ATOM   2841 O O   . LEU A 1 361 ? 133.001 120.043 141.685 1.00 4.65  ? 389 LEU A O   1 
ATOM   2842 C CB  . LEU A 1 361 ? 132.365 117.379 141.711 1.00 4.65  ? 389 LEU A CB  1 
ATOM   2843 C CG  . LEU A 1 361 ? 132.140 116.179 142.632 1.00 4.65  ? 389 LEU A CG  1 
ATOM   2844 C CD1 . LEU A 1 361 ? 131.015 115.297 142.127 1.00 4.65  ? 389 LEU A CD1 1 
ATOM   2845 C CD2 . LEU A 1 361 ? 133.421 115.376 142.771 1.00 4.65  ? 389 LEU A CD2 1 
ATOM   2846 N N   . LYS A 1 362 ? 131.018 120.742 140.911 1.00 5.74  ? 390 LYS A N   1 
ATOM   2847 C CA  . LYS A 1 362 ? 131.498 122.090 140.644 1.00 5.74  ? 390 LYS A CA  1 
ATOM   2848 C C   . LYS A 1 362 ? 131.361 123.024 141.836 1.00 5.74  ? 390 LYS A C   1 
ATOM   2849 O O   . LYS A 1 362 ? 131.786 124.181 141.744 1.00 5.74  ? 390 LYS A O   1 
ATOM   2850 C CB  . LYS A 1 362 ? 130.760 122.694 139.445 1.00 5.74  ? 390 LYS A CB  1 
ATOM   2851 C CG  . LYS A 1 362 ? 129.285 122.949 139.682 1.00 5.74  ? 390 LYS A CG  1 
ATOM   2852 C CD  . LYS A 1 362 ? 128.687 123.756 138.545 1.00 5.74  ? 390 LYS A CD  1 
ATOM   2853 C CE  . LYS A 1 362 ? 129.384 125.097 138.404 1.00 5.74  ? 390 LYS A CE  1 
ATOM   2854 N NZ  . LYS A 1 362 ? 128.718 125.963 137.395 1.00 5.74  ? 390 LYS A NZ  1 
ATOM   2855 N N   . GLU A 1 363 ? 130.770 122.566 142.940 1.00 5.24  ? 391 GLU A N   1 
ATOM   2856 C CA  . GLU A 1 363 ? 130.721 123.353 144.163 1.00 5.24  ? 391 GLU A CA  1 
ATOM   2857 C C   . GLU A 1 363 ? 131.637 122.823 145.255 1.00 5.24  ? 391 GLU A C   1 
ATOM   2858 O O   . GLU A 1 363 ? 131.836 123.517 146.254 1.00 5.24  ? 391 GLU A O   1 
ATOM   2859 C CB  . GLU A 1 363 ? 129.284 123.431 144.701 1.00 5.24  ? 391 GLU A CB  1 
ATOM   2860 C CG  . GLU A 1 363 ? 128.588 122.094 144.838 1.00 5.24  ? 391 GLU A CG  1 
ATOM   2861 C CD  . GLU A 1 363 ? 127.752 121.755 143.624 1.00 5.24  ? 391 GLU A CD  1 
ATOM   2862 O OE1 . GLU A 1 363 ? 127.864 122.476 142.612 1.00 5.24  ? 391 GLU A OE1 1 
ATOM   2863 O OE2 . GLU A 1 363 ? 126.984 120.772 143.677 1.00 5.24  ? 391 GLU A OE2 1 
ATOM   2864 N N   . HIS A 1 364 ? 132.220 121.638 145.081 1.00 5.12  ? 392 HIS A N   1 
ATOM   2865 C CA  . HIS A 1 364 ? 133.145 121.053 146.043 1.00 5.12  ? 392 HIS A CA  1 
ATOM   2866 C C   . HIS A 1 364 ? 134.547 121.643 145.956 1.00 5.12  ? 392 HIS A C   1 
ATOM   2867 O O   . HIS A 1 364 ? 135.489 121.061 146.506 1.00 5.12  ? 392 HIS A O   1 
ATOM   2868 C CB  . HIS A 1 364 ? 133.213 119.536 145.848 1.00 5.12  ? 392 HIS A CB  1 
ATOM   2869 C CG  . HIS A 1 364 ? 131.956 118.820 146.226 1.00 5.12  ? 392 HIS A CG  1 
ATOM   2870 N ND1 . HIS A 1 364 ? 131.924 117.834 147.187 1.00 5.12  ? 392 HIS A ND1 1 
ATOM   2871 C CD2 . HIS A 1 364 ? 130.685 118.953 145.781 1.00 5.12  ? 392 HIS A CD2 1 
ATOM   2872 C CE1 . HIS A 1 364 ? 130.689 117.384 147.312 1.00 5.12  ? 392 HIS A CE1 1 
ATOM   2873 N NE2 . HIS A 1 364 ? 129.917 118.047 146.470 1.00 5.12  ? 392 HIS A NE2 1 
ATOM   2874 N N   . LYS A 1 365 ? 134.711 122.778 145.283 1.00 4.26  ? 393 LYS A N   1 
ATOM   2875 C CA  . LYS A 1 365 ? 136.028 123.362 145.070 1.00 4.26  ? 393 LYS A CA  1 
ATOM   2876 C C   . LYS A 1 365 ? 136.406 124.409 146.106 1.00 4.26  ? 393 LYS A C   1 
ATOM   2877 O O   . LYS A 1 365 ? 137.598 124.670 146.297 1.00 4.26  ? 393 LYS A O   1 
ATOM   2878 C CB  . LYS A 1 365 ? 136.107 123.987 143.673 1.00 4.26  ? 393 LYS A CB  1 
ATOM   2879 C CG  . LYS A 1 365 ? 135.263 125.242 143.503 1.00 4.26  ? 393 LYS A CG  1 
ATOM   2880 C CD  . LYS A 1 365 ? 135.428 125.845 142.117 1.00 4.26  ? 393 LYS A CD  1 
ATOM   2881 C CE  . LYS A 1 365 ? 136.820 126.417 141.926 1.00 4.26  ? 393 LYS A CE  1 
ATOM   2882 N NZ  . LYS A 1 365 ? 137.028 127.637 142.753 1.00 4.26  ? 393 LYS A NZ  1 
ATOM   2883 N N   . ALA A 1 366 ? 135.429 125.016 146.778 1.00 3.38  ? 394 ALA A N   1 
ATOM   2884 C CA  . ALA A 1 366 ? 135.692 126.090 147.724 1.00 3.38  ? 394 ALA A CA  1 
ATOM   2885 C C   . ALA A 1 366 ? 135.410 125.702 149.171 1.00 3.38  ? 394 ALA A C   1 
ATOM   2886 O O   . ALA A 1 366 ? 135.461 126.568 150.047 1.00 3.38  ? 394 ALA A O   1 
ATOM   2887 C CB  . ALA A 1 366 ? 134.876 127.327 147.349 1.00 3.38  ? 394 ALA A CB  1 
ATOM   2888 N N   . LEU A 1 367 ? 135.110 124.431 149.450 1.00 3.89  ? 395 LEU A N   1 
ATOM   2889 C CA  . LEU A 1 367 ? 134.835 124.044 150.831 1.00 3.89  ? 395 LEU A CA  1 
ATOM   2890 C C   . LEU A 1 367 ? 136.082 124.104 151.701 1.00 3.89  ? 395 LEU A C   1 
ATOM   2891 O O   . LEU A 1 367 ? 135.987 124.406 152.894 1.00 3.89  ? 395 LEU A O   1 
ATOM   2892 C CB  . LEU A 1 367 ? 134.212 122.650 150.908 1.00 3.89  ? 395 LEU A CB  1 
ATOM   2893 C CG  . LEU A 1 367 ? 132.728 122.481 150.583 1.00 3.89  ? 395 LEU A CG  1 
ATOM   2894 C CD1 . LEU A 1 367 ? 132.455 122.646 149.127 1.00 3.89  ? 395 LEU A CD1 1 
ATOM   2895 C CD2 . LEU A 1 367 ? 132.235 121.127 151.064 1.00 3.89  ? 395 LEU A CD2 1 
ATOM   2896 N N   . LYS A 1 368 ? 137.256 123.810 151.144 1.00 4.05  ? 396 LYS A N   1 
ATOM   2897 C CA  . LYS A 1 368 ? 138.435 123.716 151.999 1.00 4.05  ? 396 LYS A CA  1 
ATOM   2898 C C   . LYS A 1 368 ? 138.903 125.086 152.479 1.00 4.05  ? 396 LYS A C   1 
ATOM   2899 O O   . LYS A 1 368 ? 139.232 125.251 153.659 1.00 4.05  ? 396 LYS A O   1 
ATOM   2900 C CB  . LYS A 1 368 ? 139.564 122.988 151.281 1.00 4.05  ? 396 LYS A CB  1 
ATOM   2901 C CG  . LYS A 1 368 ? 140.528 122.336 152.247 1.00 4.05  ? 396 LYS A CG  1 
ATOM   2902 C CD  . LYS A 1 368 ? 139.766 121.586 153.329 1.00 4.05  ? 396 LYS A CD  1 
ATOM   2903 C CE  . LYS A 1 368 ? 140.706 120.960 154.343 1.00 4.05  ? 396 LYS A CE  1 
ATOM   2904 N NZ  . LYS A 1 368 ? 140.083 120.873 155.692 1.00 4.05  ? 396 LYS A NZ  1 
ATOM   2905 N N   . THR A 1 369 ? 138.952 126.080 151.589 1.00 2.91  ? 397 THR A N   1 
ATOM   2906 C CA  . THR A 1 369 ? 139.373 127.408 152.022 1.00 2.91  ? 397 THR A CA  1 
ATOM   2907 C C   . THR A 1 369 ? 138.370 128.012 152.994 1.00 2.91  ? 397 THR A C   1 
ATOM   2908 O O   . THR A 1 369 ? 138.760 128.612 154.001 1.00 2.91  ? 397 THR A O   1 
ATOM   2909 C CB  . THR A 1 369 ? 139.576 128.332 150.824 1.00 2.91  ? 397 THR A CB  1 
ATOM   2910 O OG1 . THR A 1 369 ? 138.316 128.583 150.193 1.00 2.91  ? 397 THR A OG1 1 
ATOM   2911 C CG2 . THR A 1 369 ? 140.530 127.703 149.826 1.00 2.91  ? 397 THR A CG2 1 
ATOM   2912 N N   . LEU A 1 370 ? 137.073 127.859 152.719 1.00 4.28  ? 398 LEU A N   1 
ATOM   2913 C CA  . LEU A 1 370 ? 136.069 128.361 153.651 1.00 4.28  ? 398 LEU A CA  1 
ATOM   2914 C C   . LEU A 1 370 ? 136.162 127.650 154.994 1.00 4.28  ? 398 LEU A C   1 
ATOM   2915 O O   . LEU A 1 370 ? 136.026 128.279 156.049 1.00 4.28  ? 398 LEU A O   1 
ATOM   2916 C CB  . LEU A 1 370 ? 134.670 128.215 153.056 1.00 4.28  ? 398 LEU A CB  1 
ATOM   2917 C CG  . LEU A 1 370 ? 134.368 129.072 151.826 1.00 4.28  ? 398 LEU A CG  1 
ATOM   2918 C CD1 . LEU A 1 370 ? 132.936 128.867 151.369 1.00 4.28  ? 398 LEU A CD1 1 
ATOM   2919 C CD2 . LEU A 1 370 ? 134.630 130.533 152.117 1.00 4.28  ? 398 LEU A CD2 1 
ATOM   2920 N N   . GLY A 1 371 ? 136.402 126.339 154.979 1.00 3.90  ? 399 GLY A N   1 
ATOM   2921 C CA  . GLY A 1 371 ? 136.566 125.616 156.227 1.00 3.90  ? 399 GLY A CA  1 
ATOM   2922 C C   . GLY A 1 371 ? 137.769 126.087 157.019 1.00 3.90  ? 399 GLY A C   1 
ATOM   2923 O O   . GLY A 1 371 ? 137.700 126.231 158.242 1.00 3.90  ? 399 GLY A O   1 
ATOM   2924 N N   . ILE A 1 372 ? 138.887 126.331 156.335 1.00 4.15  ? 400 ILE A N   1 
ATOM   2925 C CA  . ILE A 1 372 ? 140.066 126.861 157.013 1.00 4.15  ? 400 ILE A CA  1 
ATOM   2926 C C   . ILE A 1 372 ? 139.766 128.231 157.601 1.00 4.15  ? 400 ILE A C   1 
ATOM   2927 O O   . ILE A 1 372 ? 140.170 128.540 158.728 1.00 4.15  ? 400 ILE A O   1 
ATOM   2928 C CB  . ILE A 1 372 ? 141.269 126.906 156.054 1.00 4.15  ? 400 ILE A CB  1 
ATOM   2929 C CG1 . ILE A 1 372 ? 141.771 125.493 155.765 1.00 4.15  ? 400 ILE A CG1 1 
ATOM   2930 C CG2 . ILE A 1 372 ? 142.386 127.748 156.635 1.00 4.15  ? 400 ILE A CG2 1 
ATOM   2931 C CD1 . ILE A 1 372 ? 142.867 125.437 154.726 1.00 4.15  ? 400 ILE A CD1 1 
ATOM   2932 N N   . ILE A 1 373 ? 139.053 129.075 156.851 1.00 3.85  ? 401 ILE A N   1 
ATOM   2933 C CA  . ILE A 1 373 ? 138.700 130.402 157.351 1.00 3.85  ? 401 ILE A CA  1 
ATOM   2934 C C   . ILE A 1 373 ? 137.896 130.286 158.638 1.00 3.85  ? 401 ILE A C   1 
ATOM   2935 O O   . ILE A 1 373 ? 138.223 130.910 159.655 1.00 3.85  ? 401 ILE A O   1 
ATOM   2936 C CB  . ILE A 1 373 ? 137.930 131.194 156.280 1.00 3.85  ? 401 ILE A CB  1 
ATOM   2937 C CG1 . ILE A 1 373 ? 138.858 131.598 155.138 1.00 3.85  ? 401 ILE A CG1 1 
ATOM   2938 C CG2 . ILE A 1 373 ? 137.269 132.409 156.889 1.00 3.85  ? 401 ILE A CG2 1 
ATOM   2939 C CD1 . ILE A 1 373 ? 140.025 132.427 155.578 1.00 3.85  ? 401 ILE A CD1 1 
ATOM   2940 N N   . MET A 1 374 ? 136.844 129.463 158.620 1.00 3.72  ? 402 MET A N   1 
ATOM   2941 C CA  . MET A 1 374 ? 136.001 129.320 159.803 1.00 3.72  ? 402 MET A CA  1 
ATOM   2942 C C   . MET A 1 374 ? 136.791 128.762 160.979 1.00 3.72  ? 402 MET A C   1 
ATOM   2943 O O   . MET A 1 374 ? 136.689 129.263 162.106 1.00 3.72  ? 402 MET A O   1 
ATOM   2944 C CB  . MET A 1 374 ? 134.798 128.428 159.494 1.00 3.72  ? 402 MET A CB  1 
ATOM   2945 C CG  . MET A 1 374 ? 134.054 128.796 158.228 1.00 3.72  ? 402 MET A CG  1 
ATOM   2946 S SD  . MET A 1 374 ? 132.334 128.277 158.238 1.00 3.72  ? 402 MET A SD  1 
ATOM   2947 C CE  . MET A 1 374 ? 131.787 128.927 156.665 1.00 3.72  ? 402 MET A CE  1 
ATOM   2948 N N   . GLY A 1 375 ? 137.594 127.724 160.734 1.00 5.31  ? 403 GLY A N   1 
ATOM   2949 C CA  . GLY A 1 375 ? 138.327 127.101 161.822 1.00 5.31  ? 403 GLY A CA  1 
ATOM   2950 C C   . GLY A 1 375 ? 139.342 128.035 162.449 1.00 5.31  ? 403 GLY A C   1 
ATOM   2951 O O   . GLY A 1 375 ? 139.413 128.160 163.674 1.00 5.31  ? 403 GLY A O   1 
ATOM   2952 N N   . THR A 1 376 ? 140.131 128.717 161.615 1.00 5.25  ? 404 THR A N   1 
ATOM   2953 C CA  . THR A 1 376 ? 141.121 129.656 162.129 1.00 5.25  ? 404 THR A CA  1 
ATOM   2954 C C   . THR A 1 376 ? 140.455 130.802 162.876 1.00 5.25  ? 404 THR A C   1 
ATOM   2955 O O   . THR A 1 376 ? 140.910 131.194 163.958 1.00 5.25  ? 404 THR A O   1 
ATOM   2956 C CB  . THR A 1 376 ? 141.982 130.189 160.985 1.00 5.25  ? 404 THR A CB  1 
ATOM   2957 O OG1 . THR A 1 376 ? 142.780 129.126 160.452 1.00 5.25  ? 404 THR A OG1 1 
ATOM   2958 C CG2 . THR A 1 376 ? 142.892 131.300 161.468 1.00 5.25  ? 404 THR A CG2 1 
ATOM   2959 N N   . PHE A 1 377 ? 139.364 131.341 162.327 1.00 5.75  ? 405 PHE A N   1 
ATOM   2960 C CA  . PHE A 1 377 ? 138.697 132.461 162.977 1.00 5.75  ? 405 PHE A CA  1 
ATOM   2961 C C   . PHE A 1 377 ? 138.154 132.061 164.343 1.00 5.75  ? 405 PHE A C   1 
ATOM   2962 O O   . PHE A 1 377 ? 138.357 132.769 165.338 1.00 5.75  ? 405 PHE A O   1 
ATOM   2963 C CB  . PHE A 1 377 ? 137.571 132.980 162.091 1.00 5.75  ? 405 PHE A CB  1 
ATOM   2964 C CG  . PHE A 1 377 ? 136.865 134.158 162.663 1.00 5.75  ? 405 PHE A CG  1 
ATOM   2965 C CD1 . PHE A 1 377 ? 137.448 135.409 162.627 1.00 5.75  ? 405 PHE A CD1 1 
ATOM   2966 C CD2 . PHE A 1 377 ? 135.649 134.012 163.285 1.00 5.75  ? 405 PHE A CD2 1 
ATOM   2967 C CE1 . PHE A 1 377 ? 136.808 136.500 163.166 1.00 5.75  ? 405 PHE A CE1 1 
ATOM   2968 C CE2 . PHE A 1 377 ? 135.017 135.092 163.825 1.00 5.75  ? 405 PHE A CE2 1 
ATOM   2969 C CZ  . PHE A 1 377 ? 135.590 136.338 163.769 1.00 5.75  ? 405 PHE A CZ  1 
ATOM   2970 N N   . THR A 1 378 ? 137.453 130.925 164.410 1.00 5.74  ? 406 THR A N   1 
ATOM   2971 C CA  . THR A 1 378 ? 136.913 130.472 165.687 1.00 5.74  ? 406 THR A CA  1 
ATOM   2972 C C   . THR A 1 378 ? 138.027 130.182 166.680 1.00 5.74  ? 406 THR A C   1 
ATOM   2973 O O   . THR A 1 378 ? 137.947 130.584 167.846 1.00 5.74  ? 406 THR A O   1 
ATOM   2974 C CB  . THR A 1 378 ? 136.047 129.231 165.486 1.00 5.74  ? 406 THR A CB  1 
ATOM   2975 O OG1 . THR A 1 378 ? 134.923 129.557 164.660 1.00 5.74  ? 406 THR A OG1 1 
ATOM   2976 C CG2 . THR A 1 378 ? 135.554 128.706 166.822 1.00 5.74  ? 406 THR A CG2 1 
ATOM   2977 N N   . LEU A 1 379 ? 139.087 129.503 166.231 1.00 7.30  ? 407 LEU A N   1 
ATOM   2978 C CA  . LEU A 1 379 ? 140.185 129.161 167.126 1.00 7.30  ? 407 LEU A CA  1 
ATOM   2979 C C   . LEU A 1 379 ? 140.845 130.408 167.697 1.00 7.30  ? 407 LEU A C   1 
ATOM   2980 O O   . LEU A 1 379 ? 141.209 130.439 168.877 1.00 7.30  ? 407 LEU A O   1 
ATOM   2981 C CB  . LEU A 1 379 ? 141.214 128.307 166.389 1.00 7.30  ? 407 LEU A CB  1 
ATOM   2982 C CG  . LEU A 1 379 ? 142.547 128.098 167.107 1.00 7.30  ? 407 LEU A CG  1 
ATOM   2983 C CD1 . LEU A 1 379 ? 142.344 127.329 168.402 1.00 7.30  ? 407 LEU A CD1 1 
ATOM   2984 C CD2 . LEU A 1 379 ? 143.542 127.391 166.201 1.00 7.30  ? 407 LEU A CD2 1 
ATOM   2985 N N   . CYS A 1 380 ? 141.019 131.443 166.876 1.00 7.84  ? 408 CYS A N   1 
ATOM   2986 C CA  . CYS A 1 380 ? 141.698 132.635 167.366 1.00 7.84  ? 408 CYS A CA  1 
ATOM   2987 C C   . CYS A 1 380 ? 140.801 133.494 168.252 1.00 7.84  ? 408 CYS A C   1 
ATOM   2988 O O   . CYS A 1 380 ? 141.272 134.047 169.251 1.00 7.84  ? 408 CYS A O   1 
ATOM   2989 C CB  . CYS A 1 380 ? 142.234 133.452 166.196 1.00 7.84  ? 408 CYS A CB  1 
ATOM   2990 S SG  . CYS A 1 380 ? 143.768 132.817 165.486 1.00 7.84  ? 408 CYS A SG  1 
ATOM   2991 N N   . TRP A 1 381 ? 139.516 133.629 167.920 1.00 8.69  ? 409 TRP A N   1 
ATOM   2992 C CA  . TRP A 1 381 ? 138.665 134.530 168.691 1.00 8.69  ? 409 TRP A CA  1 
ATOM   2993 C C   . TRP A 1 381 ? 137.955 133.860 169.862 1.00 8.69  ? 409 TRP A C   1 
ATOM   2994 O O   . TRP A 1 381 ? 137.301 134.561 170.642 1.00 8.69  ? 409 TRP A O   1 
ATOM   2995 C CB  . TRP A 1 381 ? 137.622 135.190 167.786 1.00 8.69  ? 409 TRP A CB  1 
ATOM   2996 C CG  . TRP A 1 381 ? 138.022 136.542 167.279 1.00 8.69  ? 409 TRP A CG  1 
ATOM   2997 C CD1 . TRP A 1 381 ? 138.402 136.857 166.010 1.00 8.69  ? 409 TRP A CD1 1 
ATOM   2998 C CD2 . TRP A 1 381 ? 138.071 137.764 168.025 1.00 8.69  ? 409 TRP A CD2 1 
ATOM   2999 N NE1 . TRP A 1 381 ? 138.689 138.196 165.917 1.00 8.69  ? 409 TRP A NE1 1 
ATOM   3000 C CE2 . TRP A 1 381 ? 138.494 138.776 167.141 1.00 8.69  ? 409 TRP A CE2 1 
ATOM   3001 C CE3 . TRP A 1 381 ? 137.800 138.101 169.353 1.00 8.69  ? 409 TRP A CE3 1 
ATOM   3002 C CZ2 . TRP A 1 381 ? 138.653 140.099 167.541 1.00 8.69  ? 409 TRP A CZ2 1 
ATOM   3003 C CZ3 . TRP A 1 381 ? 137.959 139.418 169.748 1.00 8.69  ? 409 TRP A CZ3 1 
ATOM   3004 C CH2 . TRP A 1 381 ? 138.381 140.400 168.845 1.00 8.69  ? 409 TRP A CH2 1 
ATOM   3005 N N   . LEU A 1 382 ? 138.043 132.532 170.004 1.00 8.20  ? 410 LEU A N   1 
ATOM   3006 C CA  . LEU A 1 382 ? 137.445 131.887 171.173 1.00 8.20  ? 410 LEU A CA  1 
ATOM   3007 C C   . LEU A 1 382 ? 138.138 132.254 172.481 1.00 8.20  ? 410 LEU A C   1 
ATOM   3008 O O   . LEU A 1 382 ? 137.432 132.552 173.463 1.00 8.20  ? 410 LEU A O   1 
ATOM   3009 C CB  . LEU A 1 382 ? 137.404 130.371 170.964 1.00 8.20  ? 410 LEU A CB  1 
ATOM   3010 C CG  . LEU A 1 382 ? 136.552 129.599 171.972 1.00 8.20  ? 410 LEU A CG  1 
ATOM   3011 C CD1 . LEU A 1 382 ? 135.093 130.014 171.875 1.00 8.20  ? 410 LEU A CD1 1 
ATOM   3012 C CD2 . LEU A 1 382 ? 136.698 128.106 171.758 1.00 8.20  ? 410 LEU A CD2 1 
ATOM   3013 N N   . PRO A 1 383 ? 139.477 132.238 172.587 1.00 10.07 ? 411 PRO A N   1 
ATOM   3014 C CA  . PRO A 1 383 ? 140.096 132.490 173.900 1.00 10.07 ? 411 PRO A CA  1 
ATOM   3015 C C   . PRO A 1 383 ? 139.705 133.817 174.520 1.00 10.07 ? 411 PRO A C   1 
ATOM   3016 O O   . PRO A 1 383 ? 139.559 133.899 175.745 1.00 10.07 ? 411 PRO A O   1 
ATOM   3017 C CB  . PRO A 1 383 ? 141.598 132.428 173.593 1.00 10.07 ? 411 PRO A CB  1 
ATOM   3018 C CG  . PRO A 1 383 ? 141.695 131.561 172.409 1.00 10.07 ? 411 PRO A CG  1 
ATOM   3019 C CD  . PRO A 1 383 ? 140.496 131.894 171.580 1.00 10.07 ? 411 PRO A CD  1 
ATOM   3020 N N   . PHE A 1 384 ? 139.528 134.862 173.711 1.00 11.66 ? 412 PHE A N   1 
ATOM   3021 C CA  . PHE A 1 384 ? 139.131 136.154 174.259 1.00 11.66 ? 412 PHE A CA  1 
ATOM   3022 C C   . PHE A 1 384 ? 137.783 136.051 174.962 1.00 11.66 ? 412 PHE A C   1 
ATOM   3023 O O   . PHE A 1 384 ? 137.612 136.542 176.083 1.00 11.66 ? 412 PHE A O   1 
ATOM   3024 C CB  . PHE A 1 384 ? 139.088 137.202 173.147 1.00 11.66 ? 412 PHE A CB  1 
ATOM   3025 C CG  . PHE A 1 384 ? 138.886 138.603 173.641 1.00 11.66 ? 412 PHE A CG  1 
ATOM   3026 C CD1 . PHE A 1 384 ? 139.969 139.383 174.003 1.00 11.66 ? 412 PHE A CD1 1 
ATOM   3027 C CD2 . PHE A 1 384 ? 137.615 139.139 173.748 1.00 11.66 ? 412 PHE A CD2 1 
ATOM   3028 C CE1 . PHE A 1 384 ? 139.787 140.670 174.458 1.00 11.66 ? 412 PHE A CE1 1 
ATOM   3029 C CE2 . PHE A 1 384 ? 137.427 140.425 174.204 1.00 11.66 ? 412 PHE A CE2 1 
ATOM   3030 C CZ  . PHE A 1 384 ? 138.514 141.192 174.559 1.00 11.66 ? 412 PHE A CZ  1 
ATOM   3031 N N   . PHE A 1 385 ? 136.818 135.382 174.331 1.00 10.68 ? 413 PHE A N   1 
ATOM   3032 C CA  . PHE A 1 385 ? 135.503 135.248 174.947 1.00 10.68 ? 413 PHE A CA  1 
ATOM   3033 C C   . PHE A 1 385 ? 135.530 134.315 176.150 1.00 10.68 ? 413 PHE A C   1 
ATOM   3034 O O   . PHE A 1 385 ? 134.822 134.557 177.135 1.00 10.68 ? 413 PHE A O   1 
ATOM   3035 C CB  . PHE A 1 385 ? 134.481 134.785 173.915 1.00 10.68 ? 413 PHE A CB  1 
ATOM   3036 C CG  . PHE A 1 385 ? 133.973 135.890 173.040 1.00 10.68 ? 413 PHE A CG  1 
ATOM   3037 C CD1 . PHE A 1 385 ? 132.888 136.651 173.437 1.00 10.68 ? 413 PHE A CD1 1 
ATOM   3038 C CD2 . PHE A 1 385 ? 134.598 136.193 171.844 1.00 10.68 ? 413 PHE A CD2 1 
ATOM   3039 C CE1 . PHE A 1 385 ? 132.418 137.672 172.646 1.00 10.68 ? 413 PHE A CE1 1 
ATOM   3040 C CE2 . PHE A 1 385 ? 134.134 137.219 171.050 1.00 10.68 ? 413 PHE A CE2 1 
ATOM   3041 C CZ  . PHE A 1 385 ? 133.043 137.960 171.451 1.00 10.68 ? 413 PHE A CZ  1 
ATOM   3042 N N   . ILE A 1 386 ? 136.338 133.252 176.110 1.00 13.08 ? 414 ILE A N   1 
ATOM   3043 C CA  . ILE A 1 386 ? 136.361 132.361 177.268 1.00 13.08 ? 414 ILE A CA  1 
ATOM   3044 C C   . ILE A 1 386 ? 137.005 133.055 178.467 1.00 13.08 ? 414 ILE A C   1 
ATOM   3045 O O   . ILE A 1 386 ? 136.535 132.914 179.603 1.00 13.08 ? 414 ILE A O   1 
ATOM   3046 C CB  . ILE A 1 386 ? 137.042 131.018 176.937 1.00 13.08 ? 414 ILE A CB  1 
ATOM   3047 C CG1 . ILE A 1 386 ? 138.553 131.166 176.774 1.00 13.08 ? 414 ILE A CG1 1 
ATOM   3048 C CG2 . ILE A 1 386 ? 136.427 130.403 175.690 1.00 13.08 ? 414 ILE A CG2 1 
ATOM   3049 C CD1 . ILE A 1 386 ? 139.296 129.849 176.775 1.00 13.08 ? 414 ILE A CD1 1 
ATOM   3050 N N   . VAL A 1 387 ? 138.062 133.844 178.241 1.00 13.49 ? 415 VAL A N   1 
ATOM   3051 C CA  . VAL A 1 387 ? 138.668 134.560 179.361 1.00 13.49 ? 415 VAL A CA  1 
ATOM   3052 C C   . VAL A 1 387 ? 137.766 135.695 179.829 1.00 13.49 ? 415 VAL A C   1 
ATOM   3053 O O   . VAL A 1 387 ? 137.738 136.015 181.022 1.00 13.49 ? 415 VAL A O   1 
ATOM   3054 C CB  . VAL A 1 387 ? 140.084 135.062 179.014 1.00 13.49 ? 415 VAL A CB  1 
ATOM   3055 C CG1 . VAL A 1 387 ? 140.977 133.902 178.595 1.00 13.49 ? 415 VAL A CG1 1 
ATOM   3056 C CG2 . VAL A 1 387 ? 140.044 136.136 177.948 1.00 13.49 ? 415 VAL A CG2 1 
ATOM   3057 N N   . ASN A 1 388 ? 137.010 136.318 178.920 1.00 14.45 ? 416 ASN A N   1 
ATOM   3058 C CA  . ASN A 1 388 ? 136.032 137.316 179.342 1.00 14.45 ? 416 ASN A CA  1 
ATOM   3059 C C   . ASN A 1 388 ? 134.962 136.690 180.228 1.00 14.45 ? 416 ASN A C   1 
ATOM   3060 O O   . ASN A 1 388 ? 134.569 137.269 181.250 1.00 14.45 ? 416 ASN A O   1 
ATOM   3061 C CB  . ASN A 1 388 ? 135.402 137.975 178.115 1.00 14.45 ? 416 ASN A CB  1 
ATOM   3062 C CG  . ASN A 1 388 ? 134.609 139.218 178.460 1.00 14.45 ? 416 ASN A CG  1 
ATOM   3063 O OD1 . ASN A 1 388 ? 134.519 139.610 179.622 1.00 14.45 ? 416 ASN A OD1 1 
ATOM   3064 N ND2 . ASN A 1 388 ? 134.024 139.845 177.446 1.00 14.45 ? 416 ASN A ND2 1 
ATOM   3065 N N   . ILE A 1 389 ? 134.484 135.503 179.854 1.00 14.18 ? 417 ILE A N   1 
ATOM   3066 C CA  . ILE A 1 389 ? 133.502 134.801 180.671 1.00 14.18 ? 417 ILE A CA  1 
ATOM   3067 C C   . ILE A 1 389 ? 134.096 134.437 182.025 1.00 14.18 ? 417 ILE A C   1 
ATOM   3068 O O   . ILE A 1 389 ? 133.437 134.569 183.061 1.00 14.18 ? 417 ILE A O   1 
ATOM   3069 C CB  . ILE A 1 389 ? 132.978 133.563 179.922 1.00 14.18 ? 417 ILE A CB  1 
ATOM   3070 C CG1 . ILE A 1 389 ? 131.948 133.981 178.871 1.00 14.18 ? 417 ILE A CG1 1 
ATOM   3071 C CG2 . ILE A 1 389 ? 132.378 132.557 180.892 1.00 14.18 ? 417 ILE A CG2 1 
ATOM   3072 C CD1 . ILE A 1 389 ? 130.610 134.381 179.455 1.00 14.18 ? 417 ILE A CD1 1 
ATOM   3073 N N   . VAL A 1 390 ? 135.350 133.982 182.044 1.00 16.81 ? 418 VAL A N   1 
ATOM   3074 C CA  . VAL A 1 390 ? 136.002 133.673 183.314 1.00 16.81 ? 418 VAL A CA  1 
ATOM   3075 C C   . VAL A 1 390 ? 136.090 134.918 184.190 1.00 16.81 ? 418 VAL A C   1 
ATOM   3076 O O   . VAL A 1 390 ? 135.832 134.864 185.399 1.00 16.81 ? 418 VAL A O   1 
ATOM   3077 C CB  . VAL A 1 390 ? 137.390 133.054 183.064 1.00 16.81 ? 418 VAL A CB  1 
ATOM   3078 C CG1 . VAL A 1 390 ? 138.202 133.026 184.347 1.00 16.81 ? 418 VAL A CG1 1 
ATOM   3079 C CG2 . VAL A 1 390 ? 137.247 131.651 182.498 1.00 16.81 ? 418 VAL A CG2 1 
ATOM   3080 N N   . HIS A 1 391 ? 136.448 136.059 183.596 1.00 19.70 ? 419 HIS A N   1 
ATOM   3081 C CA  . HIS A 1 391 ? 136.589 137.293 184.362 1.00 19.70 ? 419 HIS A CA  1 
ATOM   3082 C C   . HIS A 1 391 ? 135.252 137.773 184.915 1.00 19.70 ? 419 HIS A C   1 
ATOM   3083 O O   . HIS A 1 391 ? 135.186 138.257 186.051 1.00 19.70 ? 419 HIS A O   1 
ATOM   3084 C CB  . HIS A 1 391 ? 137.223 138.379 183.495 1.00 19.70 ? 419 HIS A CB  1 
ATOM   3085 C CG  . HIS A 1 391 ? 138.720 138.380 183.526 1.00 19.70 ? 419 HIS A CG  1 
ATOM   3086 N ND1 . HIS A 1 391 ? 139.479 139.235 182.757 1.00 19.70 ? 419 HIS A ND1 1 
ATOM   3087 C CD2 . HIS A 1 391 ? 139.597 137.630 184.233 1.00 19.70 ? 419 HIS A CD2 1 
ATOM   3088 C CE1 . HIS A 1 391 ? 140.760 139.013 182.989 1.00 19.70 ? 419 HIS A CE1 1 
ATOM   3089 N NE2 . HIS A 1 391 ? 140.859 138.044 183.882 1.00 19.70 ? 419 HIS A NE2 1 
ATOM   3090 N N   . VAL A 1 392 ? 134.176 137.662 184.130 1.00 18.11 ? 420 VAL A N   1 
ATOM   3091 C CA  . VAL A 1 392 ? 132.901 138.219 184.576 1.00 18.11 ? 420 VAL A CA  1 
ATOM   3092 C C   . VAL A 1 392 ? 132.357 137.453 185.778 1.00 18.11 ? 420 VAL A C   1 
ATOM   3093 O O   . VAL A 1 392 ? 131.649 138.026 186.616 1.00 18.11 ? 420 VAL A O   1 
ATOM   3094 C CB  . VAL A 1 392 ? 131.884 138.263 183.417 1.00 18.11 ? 420 VAL A CB  1 
ATOM   3095 C CG1 . VAL A 1 392 ? 131.364 136.875 183.084 1.00 18.11 ? 420 VAL A CG1 1 
ATOM   3096 C CG2 . VAL A 1 392 ? 130.736 139.205 183.753 1.00 18.11 ? 420 VAL A CG2 1 
ATOM   3097 N N   . ILE A 1 393 ? 132.671 136.160 185.894 1.00 18.35 ? 421 ILE A N   1 
ATOM   3098 C CA  . ILE A 1 393 ? 132.254 135.408 187.073 1.00 18.35 ? 421 ILE A CA  1 
ATOM   3099 C C   . ILE A 1 393 ? 133.069 135.857 188.284 1.00 18.35 ? 421 ILE A C   1 
ATOM   3100 O O   . ILE A 1 393 ? 134.143 136.458 188.166 1.00 18.35 ? 421 ILE A O   1 
ATOM   3101 C CB  . ILE A 1 393 ? 132.388 133.894 186.833 1.00 18.35 ? 421 ILE A CB  1 
ATOM   3102 C CG1 . ILE A 1 393 ? 131.860 133.528 185.448 1.00 18.35 ? 421 ILE A CG1 1 
ATOM   3103 C CG2 . ILE A 1 393 ? 131.604 133.099 187.868 1.00 18.35 ? 421 ILE A CG2 1 
ATOM   3104 C CD1 . ILE A 1 393 ? 132.027 132.067 185.096 1.00 18.35 ? 421 ILE A CD1 1 
ATOM   3105 N N   . GLN A 1 394 ? 132.540 135.557 189.474 1.00 19.09 ? 422 GLN A N   1 
ATOM   3106 C CA  . GLN A 1 394 ? 133.171 135.968 190.723 1.00 19.09 ? 422 GLN A CA  1 
ATOM   3107 C C   . GLN A 1 394 ? 134.528 135.315 190.955 1.00 19.09 ? 422 GLN A C   1 
ATOM   3108 O O   . GLN A 1 394 ? 135.169 135.614 191.969 1.00 19.09 ? 422 GLN A O   1 
ATOM   3109 C CB  . GLN A 1 394 ? 132.243 135.655 191.899 1.00 19.09 ? 422 GLN A CB  1 
ATOM   3110 C CG  . GLN A 1 394 ? 130.935 136.432 191.881 1.00 19.09 ? 422 GLN A CG  1 
ATOM   3111 C CD  . GLN A 1 394 ? 131.141 137.923 192.061 1.00 19.09 ? 422 GLN A CD  1 
ATOM   3112 O OE1 . GLN A 1 394 ? 130.979 138.702 191.122 1.00 19.09 ? 422 GLN A OE1 1 
ATOM   3113 N NE2 . GLN A 1 394 ? 131.499 138.328 193.274 1.00 19.09 ? 422 GLN A NE2 1 
ATOM   3114 N N   . ASP A 1 395 ? 134.976 134.432 190.059 1.00 20.31 ? 423 ASP A N   1 
ATOM   3115 C CA  . ASP A 1 395 ? 136.292 133.820 190.213 1.00 20.31 ? 423 ASP A CA  1 
ATOM   3116 C C   . ASP A 1 395 ? 137.392 134.875 190.173 1.00 20.31 ? 423 ASP A C   1 
ATOM   3117 O O   . ASP A 1 395 ? 138.245 134.932 191.067 1.00 20.31 ? 423 ASP A O   1 
ATOM   3118 C CB  . ASP A 1 395 ? 136.508 132.768 189.126 1.00 20.31 ? 423 ASP A CB  1 
ATOM   3119 C CG  . ASP A 1 395 ? 135.591 131.570 189.285 1.00 20.31 ? 423 ASP A CG  1 
ATOM   3120 O OD1 . ASP A 1 395 ? 135.216 131.255 190.434 1.00 20.31 ? 423 ASP A OD1 1 
ATOM   3121 O OD2 . ASP A 1 395 ? 135.245 130.943 188.262 1.00 20.31 ? 423 ASP A OD2 1 
ATOM   3122 N N   . ASN A 1 396 ? 137.380 135.722 189.145 1.00 21.70 ? 424 ASN A N   1 
ATOM   3123 C CA  . ASN A 1 396 ? 138.286 136.865 189.024 1.00 21.70 ? 424 ASN A CA  1 
ATOM   3124 C C   . ASN A 1 396 ? 139.750 136.437 189.133 1.00 21.70 ? 424 ASN A C   1 
ATOM   3125 O O   . ASN A 1 396 ? 140.486 136.848 190.031 1.00 21.70 ? 424 ASN A O   1 
ATOM   3126 C CB  . ASN A 1 396 ? 137.949 137.936 190.064 1.00 21.70 ? 424 ASN A CB  1 
ATOM   3127 C CG  . ASN A 1 396 ? 136.811 138.834 189.627 1.00 21.70 ? 424 ASN A CG  1 
ATOM   3128 O OD1 . ASN A 1 396 ? 135.640 138.530 189.857 1.00 21.70 ? 424 ASN A OD1 1 
ATOM   3129 N ND2 . ASN A 1 396 ? 137.149 139.951 188.993 1.00 21.70 ? 424 ASN A ND2 1 
ATOM   3130 N N   . LEU A 1 397 ? 140.165 135.594 188.192 1.00 22.60 ? 425 LEU A N   1 
ATOM   3131 C CA  . LEU A 1 397 ? 141.557 135.180 188.138 1.00 22.60 ? 425 LEU A CA  1 
ATOM   3132 C C   . LEU A 1 397 ? 142.436 136.343 187.680 1.00 22.60 ? 425 LEU A C   1 
ATOM   3133 O O   . LEU A 1 397 ? 141.976 137.299 187.050 1.00 22.60 ? 425 LEU A O   1 
ATOM   3134 C CB  . LEU A 1 397 ? 141.728 133.978 187.209 1.00 22.60 ? 425 LEU A CB  1 
ATOM   3135 C CG  . LEU A 1 397 ? 141.524 132.594 187.834 1.00 22.60 ? 425 LEU A CG  1 
ATOM   3136 C CD1 . LEU A 1 397 ? 140.045 132.279 188.008 1.00 22.60 ? 425 LEU A CD1 1 
ATOM   3137 C CD2 . LEU A 1 397 ? 142.212 131.519 187.005 1.00 22.60 ? 425 LEU A CD2 1 
ATOM   3138 N N   . ILE A 1 398 ? 143.724 136.252 188.008 1.00 23.98 ? 426 ILE A N   1 
ATOM   3139 C CA  . ILE A 1 398 ? 144.671 137.313 187.682 1.00 23.98 ? 426 ILE A CA  1 
ATOM   3140 C C   . ILE A 1 398 ? 145.118 137.182 186.229 1.00 23.98 ? 426 ILE A C   1 
ATOM   3141 O O   . ILE A 1 398 ? 146.085 136.480 185.912 1.00 23.98 ? 426 ILE A O   1 
ATOM   3142 C CB  . ILE A 1 398 ? 145.862 137.310 188.666 1.00 23.98 ? 426 ILE A CB  1 
ATOM   3143 C CG1 . ILE A 1 398 ? 146.869 138.408 188.305 1.00 23.98 ? 426 ILE A CG1 1 
ATOM   3144 C CG2 . ILE A 1 398 ? 146.491 135.916 188.805 1.00 23.98 ? 426 ILE A CG2 1 
ATOM   3145 C CD1 . ILE A 1 398 ? 146.325 139.810 188.461 1.00 23.98 ? 426 ILE A CD1 1 
ATOM   3146 N N   . ARG A 1 399 ? 144.398 137.855 185.331 1.00 20.13 ? 427 ARG A N   1 
ATOM   3147 C CA  . ARG A 1 399 ? 144.691 137.827 183.904 1.00 20.13 ? 427 ARG A CA  1 
ATOM   3148 C C   . ARG A 1 399 ? 144.523 139.207 183.281 1.00 20.13 ? 427 ARG A C   1 
ATOM   3149 O O   . ARG A 1 399 ? 143.993 139.334 182.175 1.00 20.13 ? 427 ARG A O   1 
ATOM   3150 C CB  . ARG A 1 399 ? 143.809 136.804 183.188 1.00 20.13 ? 427 ARG A CB  1 
ATOM   3151 N N   . LYS A 1 400 ? 144.967 140.253 183.983 1.00 17.66 ? 428 LYS A N   1 
ATOM   3152 C CA  . LYS A 1 400 ? 144.758 141.614 183.498 1.00 17.66 ? 428 LYS A CA  1 
ATOM   3153 C C   . LYS A 1 400 ? 145.585 141.908 182.253 1.00 17.66 ? 428 LYS A C   1 
ATOM   3154 O O   . LYS A 1 400 ? 145.248 142.819 181.487 1.00 17.66 ? 428 LYS A O   1 
ATOM   3155 C CB  . LYS A 1 400 ? 145.087 142.617 184.605 1.00 17.66 ? 428 LYS A CB  1 
ATOM   3156 C CG  . LYS A 1 400 ? 144.513 144.010 184.390 1.00 17.66 ? 428 LYS A CG  1 
ATOM   3157 C CD  . LYS A 1 400 ? 143.149 143.961 183.717 1.00 17.66 ? 428 LYS A CD  1 
ATOM   3158 C CE  . LYS A 1 400 ? 142.497 145.334 183.695 1.00 17.66 ? 428 LYS A CE  1 
ATOM   3159 N NZ  . LYS A 1 400 ? 141.391 145.408 182.703 1.00 17.66 ? 428 LYS A NZ  1 
ATOM   3160 N N   . GLU A 1 401 ? 146.660 141.156 182.028 1.00 17.39 ? 429 GLU A N   1 
ATOM   3161 C CA  . GLU A 1 401 ? 147.529 141.411 180.886 1.00 17.39 ? 429 GLU A CA  1 
ATOM   3162 C C   . GLU A 1 401 ? 147.167 140.565 179.670 1.00 17.39 ? 429 GLU A C   1 
ATOM   3163 O O   . GLU A 1 401 ? 147.035 141.101 178.565 1.00 17.39 ? 429 GLU A O   1 
ATOM   3164 C CB  . GLU A 1 401 ? 148.991 141.164 181.269 1.00 17.39 ? 429 GLU A CB  1 
ATOM   3165 C CG  . GLU A 1 401 ? 149.994 141.727 180.275 1.00 17.39 ? 429 GLU A CG  1 
ATOM   3166 C CD  . GLU A 1 401 ? 151.420 141.660 180.782 1.00 17.39 ? 429 GLU A CD  1 
ATOM   3167 O OE1 . GLU A 1 401 ? 151.611 141.453 181.999 1.00 17.39 ? 429 GLU A OE1 1 
ATOM   3168 O OE2 . GLU A 1 401 ? 152.352 141.813 179.965 1.00 17.39 ? 429 GLU A OE2 1 
ATOM   3169 N N   . VAL A 1 402 ? 147.004 139.251 179.849 1.00 16.98 ? 430 VAL A N   1 
ATOM   3170 C CA  . VAL A 1 402 ? 146.699 138.383 178.714 1.00 16.98 ? 430 VAL A CA  1 
ATOM   3171 C C   . VAL A 1 402 ? 145.330 138.711 178.129 1.00 16.98 ? 430 VAL A C   1 
ATOM   3172 O O   . VAL A 1 402 ? 145.083 138.477 176.938 1.00 16.98 ? 430 VAL A O   1 
ATOM   3173 C CB  . VAL A 1 402 ? 146.800 136.904 179.131 1.00 16.98 ? 430 VAL A CB  1 
ATOM   3174 C CG1 . VAL A 1 402 ? 148.208 136.584 179.604 1.00 16.98 ? 430 VAL A CG1 1 
ATOM   3175 C CG2 . VAL A 1 402 ? 145.790 136.585 180.215 1.00 16.98 ? 430 VAL A CG2 1 
ATOM   3176 N N   . TYR A 1 403 ? 144.423 139.256 178.945 1.00 17.06 ? 431 TYR A N   1 
ATOM   3177 C CA  . TYR A 1 403 ? 143.118 139.678 178.452 1.00 17.06 ? 431 TYR A CA  1 
ATOM   3178 C C   . TYR A 1 403 ? 143.239 140.746 177.374 1.00 17.06 ? 431 TYR A C   1 
ATOM   3179 O O   . TYR A 1 403 ? 142.319 140.904 176.565 1.00 17.06 ? 431 TYR A O   1 
ATOM   3180 C CB  . TYR A 1 403 ? 142.271 140.180 179.626 1.00 17.06 ? 431 TYR A CB  1 
ATOM   3181 C CG  . TYR A 1 403 ? 140.973 140.864 179.259 1.00 17.06 ? 431 TYR A CG  1 
ATOM   3182 C CD1 . TYR A 1 403 ? 140.921 142.235 179.052 1.00 17.06 ? 431 TYR A CD1 1 
ATOM   3183 C CD2 . TYR A 1 403 ? 139.795 140.143 179.151 1.00 17.06 ? 431 TYR A CD2 1 
ATOM   3184 C CE1 . TYR A 1 403 ? 139.737 142.864 178.727 1.00 17.06 ? 431 TYR A CE1 1 
ATOM   3185 C CE2 . TYR A 1 403 ? 138.605 140.764 178.828 1.00 17.06 ? 431 TYR A CE2 1 
ATOM   3186 C CZ  . TYR A 1 403 ? 138.583 142.125 178.617 1.00 17.06 ? 431 TYR A CZ  1 
ATOM   3187 O OH  . TYR A 1 403 ? 137.401 142.750 178.295 1.00 17.06 ? 431 TYR A OH  1 
ATOM   3188 N N   . ILE A 1 404 ? 144.351 141.476 177.346 1.00 18.08 ? 432 ILE A N   1 
ATOM   3189 C CA  . ILE A 1 404 ? 144.606 142.428 176.272 1.00 18.08 ? 432 ILE A CA  1 
ATOM   3190 C C   . ILE A 1 404 ? 145.358 141.777 175.113 1.00 18.08 ? 432 ILE A C   1 
ATOM   3191 O O   . ILE A 1 404 ? 145.114 142.115 173.950 1.00 18.08 ? 432 ILE A O   1 
ATOM   3192 C CB  . ILE A 1 404 ? 145.371 143.646 176.817 1.00 18.08 ? 432 ILE A CB  1 
ATOM   3193 C CG1 . ILE A 1 404 ? 144.549 144.348 177.899 1.00 18.08 ? 432 ILE A CG1 1 
ATOM   3194 C CG2 . ILE A 1 404 ? 145.708 144.619 175.701 1.00 18.08 ? 432 ILE A CG2 1 
ATOM   3195 C CD1 . ILE A 1 404 ? 143.107 144.590 177.509 1.00 18.08 ? 432 ILE A CD1 1 
ATOM   3196 N N   . LEU A 1 405 ? 146.263 140.840 175.403 1.00 16.49 ? 433 LEU A N   1 
ATOM   3197 C CA  . LEU A 1 405 ? 147.003 140.162 174.346 1.00 16.49 ? 433 LEU A CA  1 
ATOM   3198 C C   . LEU A 1 405 ? 146.093 139.328 173.453 1.00 16.49 ? 433 LEU A C   1 
ATOM   3199 O O   . LEU A 1 405 ? 146.333 139.232 172.242 1.00 16.49 ? 433 LEU A O   1 
ATOM   3200 C CB  . LEU A 1 405 ? 148.097 139.283 174.954 1.00 16.49 ? 433 LEU A CB  1 
ATOM   3201 C CG  . LEU A 1 405 ? 149.355 139.085 174.107 1.00 16.49 ? 433 LEU A CG  1 
ATOM   3202 C CD1 . LEU A 1 405 ? 149.941 140.425 173.695 1.00 16.49 ? 433 LEU A CD1 1 
ATOM   3203 C CD2 . LEU A 1 405 ? 150.382 138.257 174.861 1.00 16.49 ? 433 LEU A CD2 1 
ATOM   3204 N N   . LEU A 1 406 ? 145.052 138.717 174.022 1.00 15.43 ? 434 LEU A N   1 
ATOM   3205 C CA  . LEU A 1 406 ? 144.108 137.971 173.198 1.00 15.43 ? 434 LEU A CA  1 
ATOM   3206 C C   . LEU A 1 406 ? 143.344 138.873 172.237 1.00 15.43 ? 434 LEU A C   1 
ATOM   3207 O O   . LEU A 1 406 ? 142.956 138.420 171.155 1.00 15.43 ? 434 LEU A O   1 
ATOM   3208 C CB  . LEU A 1 406 ? 143.136 137.188 174.081 1.00 15.43 ? 434 LEU A CB  1 
ATOM   3209 C CG  . LEU A 1 406 ? 143.797 136.212 175.058 1.00 15.43 ? 434 LEU A CG  1 
ATOM   3210 C CD1 . LEU A 1 406 ? 142.761 135.314 175.703 1.00 15.43 ? 434 LEU A CD1 1 
ATOM   3211 C CD2 . LEU A 1 406 ? 144.868 135.385 174.366 1.00 15.43 ? 434 LEU A CD2 1 
ATOM   3212 N N   . ASN A 1 407 ? 143.136 140.143 172.592 1.00 14.27 ? 435 ASN A N   1 
ATOM   3213 C CA  . ASN A 1 407 ? 142.527 141.075 171.649 1.00 14.27 ? 435 ASN A CA  1 
ATOM   3214 C C   . ASN A 1 407 ? 143.417 141.283 170.429 1.00 14.27 ? 435 ASN A C   1 
ATOM   3215 O O   . ASN A 1 407 ? 142.931 141.320 169.291 1.00 14.27 ? 435 ASN A O   1 
ATOM   3216 C CB  . ASN A 1 407 ? 142.242 142.404 172.342 1.00 14.27 ? 435 ASN A CB  1 
ATOM   3217 C CG  . ASN A 1 407 ? 141.094 143.153 171.709 1.00 14.27 ? 435 ASN A CG  1 
ATOM   3218 O OD1 . ASN A 1 407 ? 140.842 143.030 170.512 1.00 14.27 ? 435 ASN A OD1 1 
ATOM   3219 N ND2 . ASN A 1 407 ? 140.389 143.939 172.511 1.00 14.27 ? 435 ASN A ND2 1 
ATOM   3220 N N   . TRP A 1 408 ? 144.727 141.413 170.642 1.00 15.58 ? 436 TRP A N   1 
ATOM   3221 C CA  . TRP A 1 408 ? 145.638 141.551 169.512 1.00 15.58 ? 436 TRP A CA  1 
ATOM   3222 C C   . TRP A 1 408 ? 145.744 140.254 168.723 1.00 15.58 ? 436 TRP A C   1 
ATOM   3223 O O   . TRP A 1 408 ? 145.936 140.283 167.500 1.00 15.58 ? 436 TRP A O   1 
ATOM   3224 C CB  . TRP A 1 408 ? 147.005 142.015 170.005 1.00 15.58 ? 436 TRP A CB  1 
ATOM   3225 C CG  . TRP A 1 408 ? 146.962 143.418 170.511 1.00 15.58 ? 436 TRP A CG  1 
ATOM   3226 C CD1 . TRP A 1 408 ? 147.004 143.823 171.811 1.00 15.58 ? 436 TRP A CD1 1 
ATOM   3227 C CD2 . TRP A 1 408 ? 146.840 144.606 169.724 1.00 15.58 ? 436 TRP A CD2 1 
ATOM   3228 N NE1 . TRP A 1 408 ? 146.926 145.191 171.883 1.00 15.58 ? 436 TRP A NE1 1 
ATOM   3229 C CE2 . TRP A 1 408 ? 146.825 145.696 170.614 1.00 15.58 ? 436 TRP A CE2 1 
ATOM   3230 C CE3 . TRP A 1 408 ? 146.751 144.855 168.352 1.00 15.58 ? 436 TRP A CE3 1 
ATOM   3231 C CZ2 . TRP A 1 408 ? 146.723 147.014 170.177 1.00 15.58 ? 436 TRP A CZ2 1 
ATOM   3232 C CZ3 . TRP A 1 408 ? 146.645 146.162 167.921 1.00 15.58 ? 436 TRP A CZ3 1 
ATOM   3233 C CH2 . TRP A 1 408 ? 146.635 147.226 168.829 1.00 15.58 ? 436 TRP A CH2 1 
ATOM   3234 N N   . ILE A 1 409 ? 145.607 139.113 169.400 1.00 12.90 ? 437 ILE A N   1 
ATOM   3235 C CA  . ILE A 1 409 ? 145.484 137.843 168.688 1.00 12.90 ? 437 ILE A CA  1 
ATOM   3236 C C   . ILE A 1 409 ? 144.275 137.875 167.761 1.00 12.90 ? 437 ILE A C   1 
ATOM   3237 O O   . ILE A 1 409 ? 144.349 137.460 166.597 1.00 12.90 ? 437 ILE A O   1 
ATOM   3238 C CB  . ILE A 1 409 ? 145.401 136.675 169.688 1.00 12.90 ? 437 ILE A CB  1 
ATOM   3239 C CG1 . ILE A 1 409 ? 146.744 136.481 170.394 1.00 12.90 ? 437 ILE A CG1 1 
ATOM   3240 C CG2 . ILE A 1 409 ? 144.965 135.400 168.988 1.00 12.90 ? 437 ILE A CG2 1 
ATOM   3241 C CD1 . ILE A 1 409 ? 146.850 135.179 171.155 1.00 12.90 ? 437 ILE A CD1 1 
ATOM   3242 N N   . GLY A 1 410 ? 143.147 138.379 168.259 1.00 11.04 ? 438 GLY A N   1 
ATOM   3243 C CA  . GLY A 1 410 ? 141.965 138.500 167.420 1.00 11.04 ? 438 GLY A CA  1 
ATOM   3244 C C   . GLY A 1 410 ? 142.173 139.438 166.246 1.00 11.04 ? 438 GLY A C   1 
ATOM   3245 O O   . GLY A 1 410 ? 141.670 139.195 165.147 1.00 11.04 ? 438 GLY A O   1 
ATOM   3246 N N   . TYR A 1 411 ? 142.904 140.530 166.465 1.00 13.78 ? 439 TYR A N   1 
ATOM   3247 C CA  . TYR A 1 411 ? 143.195 141.454 165.369 1.00 13.78 ? 439 TYR A CA  1 
ATOM   3248 C C   . TYR A 1 411 ? 144.037 140.779 164.288 1.00 13.78 ? 439 TYR A C   1 
ATOM   3249 O O   . TYR A 1 411 ? 143.761 140.912 163.087 1.00 13.78 ? 439 TYR A O   1 
ATOM   3250 C CB  . TYR A 1 411 ? 143.903 142.696 165.905 1.00 13.78 ? 439 TYR A CB  1 
ATOM   3251 C CG  . TYR A 1 411 ? 143.041 143.565 166.792 1.00 13.78 ? 439 TYR A CG  1 
ATOM   3252 C CD1 . TYR A 1 411 ? 143.551 144.123 167.954 1.00 13.78 ? 439 TYR A CD1 1 
ATOM   3253 C CD2 . TYR A 1 411 ? 141.721 143.829 166.467 1.00 13.78 ? 439 TYR A CD2 1 
ATOM   3254 C CE1 . TYR A 1 411 ? 142.774 144.917 168.767 1.00 13.78 ? 439 TYR A CE1 1 
ATOM   3255 C CE2 . TYR A 1 411 ? 140.934 144.623 167.277 1.00 13.78 ? 439 TYR A CE2 1 
ATOM   3256 C CZ  . TYR A 1 411 ? 141.468 145.165 168.424 1.00 13.78 ? 439 TYR A CZ  1 
ATOM   3257 O OH  . TYR A 1 411 ? 140.692 145.957 169.236 1.00 13.78 ? 439 TYR A OH  1 
ATOM   3258 N N   . VAL A 1 412 ? 145.073 140.044 164.699 1.00 11.89 ? 440 VAL A N   1 
ATOM   3259 C CA  . VAL A 1 412 ? 145.890 139.317 163.729 1.00 11.89 ? 440 VAL A CA  1 
ATOM   3260 C C   . VAL A 1 412 ? 145.039 138.293 162.985 1.00 11.89 ? 440 VAL A C   1 
ATOM   3261 O O   . VAL A 1 412 ? 145.210 138.073 161.778 1.00 11.89 ? 440 VAL A O   1 
ATOM   3262 C CB  . VAL A 1 412 ? 147.095 138.662 164.428 1.00 11.89 ? 440 VAL A CB  1 
ATOM   3263 C CG1 . VAL A 1 412 ? 147.909 137.849 163.441 1.00 11.89 ? 440 VAL A CG1 1 
ATOM   3264 C CG2 . VAL A 1 412 ? 147.967 139.722 165.071 1.00 11.89 ? 440 VAL A CG2 1 
ATOM   3265 N N   . ASN A 1 413 ? 144.102 137.660 163.692 1.00 9.65  ? 441 ASN A N   1 
ATOM   3266 C CA  . ASN A 1 413 ? 143.174 136.738 163.045 1.00 9.65  ? 441 ASN A CA  1 
ATOM   3267 C C   . ASN A 1 413 ? 142.355 137.444 161.974 1.00 9.65  ? 441 ASN A C   1 
ATOM   3268 O O   . ASN A 1 413 ? 142.202 136.939 160.857 1.00 9.65  ? 441 ASN A O   1 
ATOM   3269 C CB  . ASN A 1 413 ? 142.256 136.120 164.092 1.00 9.65  ? 441 ASN A CB  1 
ATOM   3270 C CG  . ASN A 1 413 ? 141.169 135.264 163.487 1.00 9.65  ? 441 ASN A CG  1 
ATOM   3271 O OD1 . ASN A 1 413 ? 141.272 134.803 162.351 1.00 9.65  ? 441 ASN A OD1 1 
ATOM   3272 N ND2 . ASN A 1 413 ? 140.113 135.045 164.252 1.00 9.65  ? 441 ASN A ND2 1 
ATOM   3273 N N   . SER A 1 414 ? 141.811 138.614 162.307 1.00 10.26 ? 442 SER A N   1 
ATOM   3274 C CA  . SER A 1 414 ? 141.043 139.375 161.330 1.00 10.26 ? 442 SER A CA  1 
ATOM   3275 C C   . SER A 1 414 ? 141.900 139.771 160.137 1.00 10.26 ? 442 SER A C   1 
ATOM   3276 O O   . SER A 1 414 ? 141.380 139.967 159.034 1.00 10.26 ? 442 SER A O   1 
ATOM   3277 C CB  . SER A 1 414 ? 140.439 140.615 161.985 1.00 10.26 ? 442 SER A CB  1 
ATOM   3278 O OG  . SER A 1 414 ? 139.759 141.409 161.033 1.00 10.26 ? 442 SER A OG  1 
ATOM   3279 N N   . GLY A 1 415 ? 143.211 139.907 160.341 1.00 11.35 ? 443 GLY A N   1 
ATOM   3280 C CA  . GLY A 1 415 ? 144.094 140.187 159.221 1.00 11.35 ? 443 GLY A CA  1 
ATOM   3281 C C   . GLY A 1 415 ? 144.491 138.970 158.408 1.00 11.35 ? 443 GLY A C   1 
ATOM   3282 O O   . GLY A 1 415 ? 144.921 139.107 157.259 1.00 11.35 ? 443 GLY A O   1 
ATOM   3283 N N   . PHE A 1 416 ? 144.362 137.772 158.986 1.00 12.24 ? 444 PHE A N   1 
ATOM   3284 C CA  . PHE A 1 416 ? 144.887 136.555 158.360 1.00 12.24 ? 444 PHE A CA  1 
ATOM   3285 C C   . PHE A 1 416 ? 144.238 136.197 157.021 1.00 12.24 ? 444 PHE A C   1 
ATOM   3286 O O   . PHE A 1 416 ? 144.847 135.454 156.245 1.00 12.24 ? 444 PHE A O   1 
ATOM   3287 C CB  . PHE A 1 416 ? 144.719 135.361 159.303 1.00 12.24 ? 444 PHE A CB  1 
ATOM   3288 C CG  . PHE A 1 416 ? 145.932 135.059 160.132 1.00 12.24 ? 444 PHE A CG  1 
ATOM   3289 C CD1 . PHE A 1 416 ? 147.155 134.820 159.532 1.00 12.24 ? 444 PHE A CD1 1 
ATOM   3290 C CD2 . PHE A 1 416 ? 145.840 134.972 161.509 1.00 12.24 ? 444 PHE A CD2 1 
ATOM   3291 C CE1 . PHE A 1 416 ? 148.269 134.531 160.293 1.00 12.24 ? 444 PHE A CE1 1 
ATOM   3292 C CE2 . PHE A 1 416 ? 146.948 134.678 162.275 1.00 12.24 ? 444 PHE A CE2 1 
ATOM   3293 C CZ  . PHE A 1 416 ? 148.165 134.459 161.666 1.00 12.24 ? 444 PHE A CZ  1 
ATOM   3294 N N   . ASN A 1 417 ? 143.029 136.684 156.735 1.00 11.15 ? 445 ASN A N   1 
ATOM   3295 C CA  . ASN A 1 417 ? 142.222 136.099 155.661 1.00 11.15 ? 445 ASN A CA  1 
ATOM   3296 C C   . ASN A 1 417 ? 142.881 136.130 154.282 1.00 11.15 ? 445 ASN A C   1 
ATOM   3297 O O   . ASN A 1 417 ? 142.871 135.090 153.596 1.00 11.15 ? 445 ASN A O   1 
ATOM   3298 C CB  . ASN A 1 417 ? 140.848 136.778 155.636 1.00 11.15 ? 445 ASN A CB  1 
ATOM   3299 C CG  . ASN A 1 417 ? 139.986 136.388 156.820 1.00 11.15 ? 445 ASN A CG  1 
ATOM   3300 O OD1 . ASN A 1 417 ? 140.076 135.273 157.326 1.00 11.15 ? 445 ASN A OD1 1 
ATOM   3301 N ND2 . ASN A 1 417 ? 139.153 137.311 157.275 1.00 11.15 ? 445 ASN A ND2 1 
ATOM   3302 N N   . PRO A 1 418 ? 143.442 137.248 153.802 1.00 13.70 ? 446 PRO A N   1 
ATOM   3303 C CA  . PRO A 1 418 ? 144.057 137.219 152.463 1.00 13.70 ? 446 PRO A CA  1 
ATOM   3304 C C   . PRO A 1 418 ? 145.193 136.222 152.339 1.00 13.70 ? 446 PRO A C   1 
ATOM   3305 O O   . PRO A 1 418 ? 145.437 135.713 151.239 1.00 13.70 ? 446 PRO A O   1 
ATOM   3306 C CB  . PRO A 1 418 ? 144.547 138.660 152.273 1.00 13.70 ? 446 PRO A CB  1 
ATOM   3307 C CG  . PRO A 1 418 ? 143.673 139.468 153.155 1.00 13.70 ? 446 PRO A CG  1 
ATOM   3308 C CD  . PRO A 1 418 ? 143.451 138.610 154.363 1.00 13.70 ? 446 PRO A CD  1 
ATOM   3309 N N   . LEU A 1 419 ? 145.889 135.918 153.435 1.00 15.17 ? 447 LEU A N   1 
ATOM   3310 C CA  . LEU A 1 419 ? 146.938 134.905 153.386 1.00 15.17 ? 447 LEU A CA  1 
ATOM   3311 C C   . LEU A 1 419 ? 146.363 133.543 153.013 1.00 15.17 ? 447 LEU A C   1 
ATOM   3312 O O   . LEU A 1 419 ? 146.970 132.794 152.241 1.00 15.17 ? 447 LEU A O   1 
ATOM   3313 C CB  . LEU A 1 419 ? 147.672 134.852 154.730 1.00 15.17 ? 447 LEU A CB  1 
ATOM   3314 C CG  . LEU A 1 419 ? 148.699 133.760 155.051 1.00 15.17 ? 447 LEU A CG  1 
ATOM   3315 C CD1 . LEU A 1 419 ? 149.710 134.300 156.046 1.00 15.17 ? 447 LEU A CD1 1 
ATOM   3316 C CD2 . LEU A 1 419 ? 148.047 132.507 155.619 1.00 15.17 ? 447 LEU A CD2 1 
ATOM   3317 N N   . ILE A 1 420 ? 145.194 133.203 153.561 1.00 14.26 ? 448 ILE A N   1 
ATOM   3318 C CA  . ILE A 1 420 ? 144.541 131.950 153.195 1.00 14.26 ? 448 ILE A CA  1 
ATOM   3319 C C   . ILE A 1 420 ? 144.006 132.017 151.769 1.00 14.26 ? 448 ILE A C   1 
ATOM   3320 O O   . ILE A 1 420 ? 144.159 131.066 150.994 1.00 14.26 ? 448 ILE A O   1 
ATOM   3321 C CB  . ILE A 1 420 ? 143.428 131.609 154.202 1.00 14.26 ? 448 ILE A CB  1 
ATOM   3322 C CG1 . ILE A 1 420 ? 144.029 131.325 155.577 1.00 14.26 ? 448 ILE A CG1 1 
ATOM   3323 C CG2 . ILE A 1 420 ? 142.631 130.413 153.728 1.00 14.26 ? 448 ILE A CG2 1 
ATOM   3324 C CD1 . ILE A 1 420 ? 144.980 130.152 155.588 1.00 14.26 ? 448 ILE A CD1 1 
ATOM   3325 N N   . TYR A 1 421 ? 143.379 133.137 151.394 1.00 14.82 ? 449 TYR A N   1 
ATOM   3326 C CA  . TYR A 1 421 ? 142.826 133.238 150.043 1.00 14.82 ? 449 TYR A CA  1 
ATOM   3327 C C   . TYR A 1 421 ? 143.893 133.223 148.955 1.00 14.82 ? 449 TYR A C   1 
ATOM   3328 O O   . TYR A 1 421 ? 143.586 132.861 147.815 1.00 14.82 ? 449 TYR A O   1 
ATOM   3329 C CB  . TYR A 1 421 ? 141.969 134.496 149.901 1.00 14.82 ? 449 TYR A CB  1 
ATOM   3330 C CG  . TYR A 1 421 ? 140.688 134.458 150.694 1.00 14.82 ? 449 TYR A CG  1 
ATOM   3331 C CD1 . TYR A 1 421 ? 140.210 133.266 151.216 1.00 14.82 ? 449 TYR A CD1 1 
ATOM   3332 C CD2 . TYR A 1 421 ? 139.954 135.612 150.920 1.00 14.82 ? 449 TYR A CD2 1 
ATOM   3333 C CE1 . TYR A 1 421 ? 139.038 133.224 151.939 1.00 14.82 ? 449 TYR A CE1 1 
ATOM   3334 C CE2 . TYR A 1 421 ? 138.785 135.582 151.646 1.00 14.82 ? 449 TYR A CE2 1 
ATOM   3335 C CZ  . TYR A 1 421 ? 138.329 134.385 152.151 1.00 14.82 ? 449 TYR A CZ  1 
ATOM   3336 O OH  . TYR A 1 421 ? 137.161 134.345 152.874 1.00 14.82 ? 449 TYR A OH  1 
ATOM   3337 N N   . CYS A 1 422 ? 145.131 133.607 149.271 1.00 16.82 ? 450 CYS A N   1 
ATOM   3338 C CA  . CYS A 1 422 ? 146.195 133.553 148.276 1.00 16.82 ? 450 CYS A CA  1 
ATOM   3339 C C   . CYS A 1 422 ? 146.539 132.125 147.873 1.00 16.82 ? 450 CYS A C   1 
ATOM   3340 O O   . CYS A 1 422 ? 147.122 131.920 146.803 1.00 16.82 ? 450 CYS A O   1 
ATOM   3341 C CB  . CYS A 1 422 ? 147.445 134.258 148.805 1.00 16.82 ? 450 CYS A CB  1 
ATOM   3342 S SG  . CYS A 1 422 ? 148.805 134.394 147.621 1.00 16.82 ? 450 CYS A SG  1 
ATOM   3343 N N   . ARG A 1 423 ? 146.188 131.137 148.699 1.00 17.54 ? 451 ARG A N   1 
ATOM   3344 C CA  . ARG A 1 423 ? 146.502 129.750 148.375 1.00 17.54 ? 451 ARG A CA  1 
ATOM   3345 C C   . ARG A 1 423 ? 145.745 129.270 147.143 1.00 17.54 ? 451 ARG A C   1 
ATOM   3346 O O   . ARG A 1 423 ? 146.244 128.407 146.411 1.00 17.54 ? 451 ARG A O   1 
ATOM   3347 C CB  . ARG A 1 423 ? 146.193 128.851 149.574 1.00 17.54 ? 451 ARG A CB  1 
ATOM   3348 C CG  . ARG A 1 423 ? 146.693 127.424 149.432 1.00 17.54 ? 451 ARG A CG  1 
ATOM   3349 C CD  . ARG A 1 423 ? 146.307 126.574 150.633 1.00 17.54 ? 451 ARG A CD  1 
ATOM   3350 N NE  . ARG A 1 423 ? 147.001 126.987 151.850 1.00 17.54 ? 451 ARG A NE  1 
ATOM   3351 C CZ  . ARG A 1 423 ? 146.795 126.448 153.047 1.00 17.54 ? 451 ARG A CZ  1 
ATOM   3352 N NH1 . ARG A 1 423 ? 145.914 125.468 153.193 1.00 17.54 ? 451 ARG A NH1 1 
ATOM   3353 N NH2 . ARG A 1 423 ? 147.471 126.887 154.100 1.00 17.54 ? 451 ARG A NH2 1 
ATOM   3354 N N   . SER A 1 424 ? 144.556 129.808 146.898 1.00 18.33 ? 452 SER A N   1 
ATOM   3355 C CA  . SER A 1 424 ? 143.751 129.365 145.764 1.00 18.33 ? 452 SER A CA  1 
ATOM   3356 C C   . SER A 1 424 ? 144.452 129.716 144.455 1.00 18.33 ? 452 SER A C   1 
ATOM   3357 O O   . SER A 1 424 ? 144.869 130.865 144.270 1.00 18.33 ? 452 SER A O   1 
ATOM   3358 C CB  . SER A 1 424 ? 142.365 130.003 145.812 1.00 18.33 ? 452 SER A CB  1 
ATOM   3359 O OG  . SER A 1 424 ? 141.487 129.385 144.887 1.00 18.33 ? 452 SER A OG  1 
ATOM   3360 N N   . PRO A 1 425 ? 144.609 128.761 143.536 1.00 17.75 ? 453 PRO A N   1 
ATOM   3361 C CA  . PRO A 1 425 ? 145.356 129.048 142.300 1.00 17.75 ? 453 PRO A CA  1 
ATOM   3362 C C   . PRO A 1 425 ? 144.733 130.129 141.433 1.00 17.75 ? 453 PRO A C   1 
ATOM   3363 O O   . PRO A 1 425 ? 145.470 130.892 140.796 1.00 17.75 ? 453 PRO A O   1 
ATOM   3364 C CB  . PRO A 1 425 ? 145.375 127.692 141.582 1.00 17.75 ? 453 PRO A CB  1 
ATOM   3365 C CG  . PRO A 1 425 ? 144.201 126.953 142.134 1.00 17.75 ? 453 PRO A CG  1 
ATOM   3366 C CD  . PRO A 1 425 ? 144.080 127.388 143.562 1.00 17.75 ? 453 PRO A CD  1 
ATOM   3367 N N   . ASP A 1 426 ? 143.401 130.222 141.382 1.00 17.75 ? 454 ASP A N   1 
ATOM   3368 C CA  . ASP A 1 426 ? 142.772 131.212 140.513 1.00 17.75 ? 454 ASP A CA  1 
ATOM   3369 C C   . ASP A 1 426 ? 142.997 132.632 141.017 1.00 17.75 ? 454 ASP A C   1 
ATOM   3370 O O   . ASP A 1 426 ? 143.076 133.567 140.213 1.00 17.75 ? 454 ASP A O   1 
ATOM   3371 C CB  . ASP A 1 426 ? 141.277 130.925 140.371 1.00 17.75 ? 454 ASP A CB  1 
ATOM   3372 C CG  . ASP A 1 426 ? 140.583 130.776 141.704 1.00 17.75 ? 454 ASP A CG  1 
ATOM   3373 O OD1 . ASP A 1 426 ? 141.282 130.682 142.733 1.00 17.75 ? 454 ASP A OD1 1 
ATOM   3374 O OD2 . ASP A 1 426 ? 139.335 130.756 141.723 1.00 17.75 ? 454 ASP A OD2 1 
ATOM   3375 N N   . PHE A 1 427 ? 143.098 132.816 142.335 1.00 16.35 ? 455 PHE A N   1 
ATOM   3376 C CA  . PHE A 1 427 ? 143.395 134.135 142.879 1.00 16.35 ? 455 PHE A CA  1 
ATOM   3377 C C   . PHE A 1 427 ? 144.831 134.562 142.605 1.00 16.35 ? 455 PHE A C   1 
ATOM   3378 O O   . PHE A 1 427 ? 145.115 135.764 142.601 1.00 16.35 ? 455 PHE A O   1 
ATOM   3379 C CB  . PHE A 1 427 ? 143.128 134.160 144.386 1.00 16.35 ? 455 PHE A CB  1 
ATOM   3380 C CG  . PHE A 1 427 ? 141.704 134.487 144.751 1.00 16.35 ? 455 PHE A CG  1 
ATOM   3381 C CD1 . PHE A 1 427 ? 141.280 135.802 144.831 1.00 16.35 ? 455 PHE A CD1 1 
ATOM   3382 C CD2 . PHE A 1 427 ? 140.795 133.480 145.027 1.00 16.35 ? 455 PHE A CD2 1 
ATOM   3383 C CE1 . PHE A 1 427 ? 139.974 136.106 145.171 1.00 16.35 ? 455 PHE A CE1 1 
ATOM   3384 C CE2 . PHE A 1 427 ? 139.489 133.780 145.367 1.00 16.35 ? 455 PHE A CE2 1 
ATOM   3385 C CZ  . PHE A 1 427 ? 139.079 135.094 145.439 1.00 16.35 ? 455 PHE A CZ  1 
ATOM   3386 N N   . ARG A 1 428 ? 145.739 133.609 142.377 1.00 18.52 ? 456 ARG A N   1 
ATOM   3387 C CA  . ARG A 1 428 ? 147.148 133.947 142.199 1.00 18.52 ? 456 ARG A CA  1 
ATOM   3388 C C   . ARG A 1 428 ? 147.370 134.765 140.933 1.00 18.52 ? 456 ARG A C   1 
ATOM   3389 O O   . ARG A 1 428 ? 148.013 135.821 140.967 1.00 18.52 ? 456 ARG A O   1 
ATOM   3390 C CB  . ARG A 1 428 ? 147.992 132.672 142.161 1.00 18.52 ? 456 ARG A CB  1 
ATOM   3391 C CG  . ARG A 1 428 ? 148.238 132.029 143.514 1.00 18.52 ? 456 ARG A CG  1 
ATOM   3392 C CD  . ARG A 1 428 ? 148.963 130.702 143.351 1.00 18.52 ? 456 ARG A CD  1 
ATOM   3393 N NE  . ARG A 1 428 ? 149.174 130.018 144.624 1.00 18.52 ? 456 ARG A NE  1 
ATOM   3394 C CZ  . ARG A 1 428 ? 150.342 129.958 145.255 1.00 18.52 ? 456 ARG A CZ  1 
ATOM   3395 N NH1 . ARG A 1 428 ? 151.411 130.539 144.730 1.00 18.52 ? 456 ARG A NH1 1 
ATOM   3396 N NH2 . ARG A 1 428 ? 150.443 129.312 146.408 1.00 18.52 ? 456 ARG A NH2 1 
ATOM   3397 N N   . ILE A 1 429 ? 146.845 134.292 139.801 1.00 18.35 ? 457 ILE A N   1 
ATOM   3398 C CA  . ILE A 1 429 ? 147.102 134.958 138.527 1.00 18.35 ? 457 ILE A CA  1 
ATOM   3399 C C   . ILE A 1 429 ? 146.419 136.320 138.483 1.00 18.35 ? 457 ILE A C   1 
ATOM   3400 O O   . ILE A 1 429 ? 146.905 137.250 137.828 1.00 18.35 ? 457 ILE A O   1 
ATOM   3401 C CB  . ILE A 1 429 ? 146.674 134.057 137.354 1.00 18.35 ? 457 ILE A CB  1 
ATOM   3402 C CG1 . ILE A 1 429 ? 145.269 133.499 137.581 1.00 18.35 ? 457 ILE A CG1 1 
ATOM   3403 C CG2 . ILE A 1 429 ? 147.672 132.924 137.156 1.00 18.35 ? 457 ILE A CG2 1 
ATOM   3404 C CD1 . ILE A 1 429 ? 144.774 132.641 136.442 1.00 18.35 ? 457 ILE A CD1 1 
ATOM   3405 N N   . ALA A 1 430 ? 145.281 136.460 139.167 1.00 19.22 ? 458 ALA A N   1 
ATOM   3406 C CA  . ALA A 1 430 ? 144.648 137.771 139.282 1.00 19.22 ? 458 ALA A CA  1 
ATOM   3407 C C   . ALA A 1 430 ? 145.523 138.736 140.072 1.00 19.22 ? 458 ALA A C   1 
ATOM   3408 O O   . ALA A 1 430 ? 145.616 139.921 139.730 1.00 19.22 ? 458 ALA A O   1 
ATOM   3409 C CB  . ALA A 1 430 ? 143.270 137.636 139.930 1.00 19.22 ? 458 ALA A CB  1 
ATOM   3410 N N   . PHE A 1 431 ? 146.165 138.250 141.138 1.00 19.05 ? 459 PHE A N   1 
ATOM   3411 C CA  . PHE A 1 431 ? 147.102 139.084 141.886 1.00 19.05 ? 459 PHE A CA  1 
ATOM   3412 C C   . PHE A 1 431 ? 148.305 139.460 141.029 1.00 19.05 ? 459 PHE A C   1 
ATOM   3413 O O   . PHE A 1 431 ? 148.802 140.590 141.104 1.00 19.05 ? 459 PHE A O   1 
ATOM   3414 C CB  . PHE A 1 431 ? 147.560 138.360 143.154 1.00 19.05 ? 459 PHE A CB  1 
ATOM   3415 C CG  . PHE A 1 431 ? 146.549 138.372 144.268 1.00 19.05 ? 459 PHE A CG  1 
ATOM   3416 C CD1 . PHE A 1 431 ? 145.353 139.056 144.138 1.00 19.05 ? 459 PHE A CD1 1 
ATOM   3417 C CD2 . PHE A 1 431 ? 146.801 137.696 145.451 1.00 19.05 ? 459 PHE A CD2 1 
ATOM   3418 C CE1 . PHE A 1 431 ? 144.428 139.062 145.167 1.00 19.05 ? 459 PHE A CE1 1 
ATOM   3419 C CE2 . PHE A 1 431 ? 145.880 137.700 146.481 1.00 19.05 ? 459 PHE A CE2 1 
ATOM   3420 C CZ  . PHE A 1 431 ? 144.694 138.384 146.339 1.00 19.05 ? 459 PHE A CZ  1 
ATOM   3421 N N   . GLN A 1 432 ? 148.791 138.521 140.212 1.00 21.62 ? 460 GLN A N   1 
ATOM   3422 C CA  . GLN A 1 432 ? 149.960 138.786 139.380 1.00 21.62 ? 460 GLN A CA  1 
ATOM   3423 C C   . GLN A 1 432 ? 149.677 139.848 138.326 1.00 21.62 ? 460 GLN A C   1 
ATOM   3424 O O   . GLN A 1 432 ? 150.614 140.439 137.777 1.00 21.62 ? 460 GLN A O   1 
ATOM   3425 C CB  . GLN A 1 432 ? 150.434 137.495 138.713 1.00 21.62 ? 460 GLN A CB  1 
ATOM   3426 C CG  . GLN A 1 432 ? 151.085 136.506 139.664 1.00 21.62 ? 460 GLN A CG  1 
ATOM   3427 C CD  . GLN A 1 432 ? 152.416 137.001 140.195 1.00 21.62 ? 460 GLN A CD  1 
ATOM   3428 O OE1 . GLN A 1 432 ? 153.176 137.656 139.484 1.00 21.62 ? 460 GLN A OE1 1 
ATOM   3429 N NE2 . GLN A 1 432 ? 152.705 136.685 141.452 1.00 21.62 ? 460 GLN A NE2 1 
ATOM   3430 N N   . GLU A 1 433 ? 148.401 140.094 138.018 1.00 21.48 ? 461 GLU A N   1 
ATOM   3431 C CA  . GLU A 1 433 ? 148.062 141.143 137.062 1.00 21.48 ? 461 GLU A CA  1 
ATOM   3432 C C   . GLU A 1 433 ? 148.498 142.512 137.570 1.00 21.48 ? 461 GLU A C   1 
ATOM   3433 O O   . GLU A 1 433 ? 149.041 143.322 136.810 1.00 21.48 ? 461 GLU A O   1 
ATOM   3434 C CB  . GLU A 1 433 ? 146.561 141.130 136.778 1.00 21.48 ? 461 GLU A CB  1 
ATOM   3435 N N   . LEU A 1 434 ? 148.270 142.787 138.857 1.00 22.78 ? 462 LEU A N   1 
ATOM   3436 C CA  . LEU A 1 434 ? 148.686 144.064 139.427 1.00 22.78 ? 462 LEU A CA  1 
ATOM   3437 C C   . LEU A 1 434 ? 150.196 144.118 139.623 1.00 22.78 ? 462 LEU A C   1 
ATOM   3438 O O   . LEU A 1 434 ? 150.818 145.166 139.416 1.00 22.78 ? 462 LEU A O   1 
ATOM   3439 C CB  . LEU A 1 434 ? 147.960 144.309 140.749 1.00 22.78 ? 462 LEU A CB  1 
ATOM   3440 C CG  . LEU A 1 434 ? 146.637 145.076 140.669 1.00 22.78 ? 462 LEU A CG  1 
ATOM   3441 C CD1 . LEU A 1 434 ? 145.563 144.250 139.979 1.00 22.78 ? 462 LEU A CD1 1 
ATOM   3442 C CD2 . LEU A 1 434 ? 146.177 145.500 142.054 1.00 22.78 ? 462 LEU A CD2 1 
ATOM   3443 N N   . LEU A 1 435 ? 150.801 143.004 140.022 1.00 23.59 ? 463 LEU A N   1 
ATOM   3444 C CA  . LEU A 1 435 ? 152.246 142.942 140.215 1.00 23.59 ? 463 LEU A CA  1 
ATOM   3445 C C   . LEU A 1 435 ? 152.976 143.005 138.877 1.00 23.59 ? 463 LEU A C   1 
ATOM   3446 O O   . LEU A 1 435 ? 152.377 142.800 137.821 1.00 23.59 ? 463 LEU A O   1 
ATOM   3447 C CB  . LEU A 1 435 ? 152.631 141.668 140.972 1.00 23.59 ? 463 LEU A CB  1 
ATOM   3448 C CG  . LEU A 1 435 ? 154.066 141.563 141.496 1.00 23.59 ? 463 LEU A CG  1 
ATOM   3449 C CD1 . LEU A 1 435 ? 154.082 140.929 142.877 1.00 23.59 ? 463 LEU A CD1 1 
ATOM   3450 C CD2 . LEU A 1 435 ? 154.940 140.767 140.536 1.00 23.59 ? 463 LEU A CD2 1 
ATOM   3451 N N   . THR B 2 13  ? 153.563 134.239 121.364 1.00 11.62 ? 13  THR B N   1 
ATOM   3452 C CA  . THR B 2 13  ? 154.318 135.459 121.615 1.00 11.62 ? 13  THR B CA  1 
ATOM   3453 C C   . THR B 2 13  ? 153.633 136.660 120.978 1.00 11.62 ? 13  THR B C   1 
ATOM   3454 O O   . THR B 2 13  ? 152.443 136.891 121.182 1.00 11.62 ? 13  THR B O   1 
ATOM   3455 C CB  . THR B 2 13  ? 155.754 135.358 121.072 1.00 11.62 ? 13  THR B CB  1 
ATOM   3456 O OG1 . THR B 2 13  ? 155.717 135.169 119.653 1.00 11.62 ? 13  THR B OG1 1 
ATOM   3457 C CG2 . THR B 2 13  ? 156.479 134.187 121.712 1.00 11.62 ? 13  THR B CG2 1 
ATOM   3458 N N   . ASP B 2 14  ? 154.401 137.425 120.206 1.00 12.14 ? 14  ASP B N   1 
ATOM   3459 C CA  . ASP B 2 14  ? 153.883 138.560 119.455 1.00 12.14 ? 14  ASP B CA  1 
ATOM   3460 C C   . ASP B 2 14  ? 153.622 138.225 117.995 1.00 12.14 ? 14  ASP B C   1 
ATOM   3461 O O   . ASP B 2 14  ? 152.593 138.628 117.445 1.00 12.14 ? 14  ASP B O   1 
ATOM   3462 C CB  . ASP B 2 14  ? 154.860 139.738 119.536 1.00 12.14 ? 14  ASP B CB  1 
ATOM   3463 C CG  . ASP B 2 14  ? 154.700 140.543 120.808 1.00 12.14 ? 14  ASP B CG  1 
ATOM   3464 O OD1 . ASP B 2 14  ? 153.547 140.763 121.234 1.00 12.14 ? 14  ASP B OD1 1 
ATOM   3465 O OD2 . ASP B 2 14  ? 155.729 140.957 121.381 1.00 12.14 ? 14  ASP B OD2 1 
ATOM   3466 N N   . ARG B 2 15  ? 154.534 137.496 117.358 1.00 11.47 ? 15  ARG B N   1 
ATOM   3467 C CA  . ARG B 2 15  ? 154.391 137.136 115.950 1.00 11.47 ? 15  ARG B CA  1 
ATOM   3468 C C   . ARG B 2 15  ? 155.319 135.966 115.671 1.00 11.47 ? 15  ARG B C   1 
ATOM   3469 O O   . ARG B 2 15  ? 156.540 136.107 115.789 1.00 11.47 ? 15  ARG B O   1 
ATOM   3470 C CB  . ARG B 2 15  ? 154.724 138.322 115.047 1.00 11.47 ? 15  ARG B CB  1 
ATOM   3471 C CG  . ARG B 2 15  ? 154.232 138.170 113.626 1.00 11.47 ? 15  ARG B CG  1 
ATOM   3472 C CD  . ARG B 2 15  ? 154.416 139.447 112.830 1.00 11.47 ? 15  ARG B CD  1 
ATOM   3473 N NE  . ARG B 2 15  ? 153.594 139.455 111.625 1.00 11.47 ? 15  ARG B NE  1 
ATOM   3474 C CZ  . ARG B 2 15  ? 152.304 139.774 111.601 1.00 11.47 ? 15  ARG B CZ  1 
ATOM   3475 N NH1 . ARG B 2 15  ? 151.680 140.114 112.720 1.00 11.47 ? 15  ARG B NH1 1 
ATOM   3476 N NH2 . ARG B 2 15  ? 151.636 139.752 110.456 1.00 11.47 ? 15  ARG B NH2 1 
ATOM   3477 N N   . VAL B 2 16  ? 154.748 134.816 115.310 1.00 11.61 ? 16  VAL B N   1 
ATOM   3478 C CA  . VAL B 2 16  ? 155.569 133.632 115.078 1.00 11.61 ? 16  VAL B CA  1 
ATOM   3479 C C   . VAL B 2 16  ? 156.391 133.783 113.802 1.00 11.61 ? 16  VAL B C   1 
ATOM   3480 O O   . VAL B 2 16  ? 157.579 133.443 113.772 1.00 11.61 ? 16  VAL B O   1 
ATOM   3481 C CB  . VAL B 2 16  ? 154.689 132.372 115.049 1.00 11.61 ? 16  VAL B CB  1 
ATOM   3482 C CG1 . VAL B 2 16  ? 155.551 131.134 114.901 1.00 11.61 ? 16  VAL B CG1 1 
ATOM   3483 C CG2 . VAL B 2 16  ? 153.868 132.296 116.318 1.00 11.61 ? 16  VAL B CG2 1 
ATOM   3484 N N   . VAL B 2 17  ? 155.781 134.289 112.734 1.00 12.02 ? 17  VAL B N   1 
ATOM   3485 C CA  . VAL B 2 17  ? 156.484 134.584 111.490 1.00 12.02 ? 17  VAL B CA  1 
ATOM   3486 C C   . VAL B 2 17  ? 156.327 136.071 111.192 1.00 12.02 ? 17  VAL B C   1 
ATOM   3487 O O   . VAL B 2 17  ? 155.207 136.593 111.160 1.00 12.02 ? 17  VAL B O   1 
ATOM   3488 C CB  . VAL B 2 17  ? 155.988 133.701 110.326 1.00 12.02 ? 17  VAL B CB  1 
ATOM   3489 C CG1 . VAL B 2 17  ? 154.532 133.980 109.978 1.00 12.02 ? 17  VAL B CG1 1 
ATOM   3490 C CG2 . VAL B 2 17  ? 156.875 133.891 109.107 1.00 12.02 ? 17  VAL B CG2 1 
ATOM   3491 N N   . LYS B 2 18  ? 157.453 136.758 111.012 1.00 12.15 ? 18  LYS B N   1 
ATOM   3492 C CA  . LYS B 2 18  ? 157.467 138.207 110.872 1.00 12.15 ? 18  LYS B CA  1 
ATOM   3493 C C   . LYS B 2 18  ? 157.567 138.675 109.427 1.00 12.15 ? 18  LYS B C   1 
ATOM   3494 O O   . LYS B 2 18  ? 157.596 139.885 109.186 1.00 12.15 ? 18  LYS B O   1 
ATOM   3495 C CB  . LYS B 2 18  ? 158.626 138.801 111.681 1.00 12.15 ? 18  LYS B CB  1 
ATOM   3496 C CG  . LYS B 2 18  ? 158.624 138.424 113.155 1.00 12.15 ? 18  LYS B CG  1 
ATOM   3497 C CD  . LYS B 2 18  ? 158.473 139.654 114.039 1.00 12.15 ? 18  LYS B CD  1 
ATOM   3498 C CE  . LYS B 2 18  ? 158.252 139.271 115.494 1.00 12.15 ? 18  LYS B CE  1 
ATOM   3499 N NZ  . LYS B 2 18  ? 158.273 140.460 116.390 1.00 12.15 ? 18  LYS B NZ  1 
ATOM   3500 N N   . ALA B 2 19  ? 157.622 137.757 108.462 1.00 13.16 ? 19  ALA B N   1 
ATOM   3501 C CA  . ALA B 2 19  ? 157.763 138.167 107.069 1.00 13.16 ? 19  ALA B CA  1 
ATOM   3502 C C   . ALA B 2 19  ? 156.491 138.813 106.535 1.00 13.16 ? 19  ALA B C   1 
ATOM   3503 O O   . ALA B 2 19  ? 156.565 139.721 105.700 1.00 13.16 ? 19  ALA B O   1 
ATOM   3504 C CB  . ALA B 2 19  ? 158.152 136.970 106.204 1.00 13.16 ? 19  ALA B CB  1 
ATOM   3505 N N   . VAL B 2 20  ? 155.331 138.366 106.994 1.00 12.08 ? 20  VAL B N   1 
ATOM   3506 C CA  . VAL B 2 20  ? 154.062 138.885 106.481 1.00 12.08 ? 20  VAL B CA  1 
ATOM   3507 C C   . VAL B 2 20  ? 153.802 140.259 107.096 1.00 12.08 ? 20  VAL B C   1 
ATOM   3508 O O   . VAL B 2 20  ? 153.831 140.393 108.329 1.00 12.08 ? 20  VAL B O   1 
ATOM   3509 C CB  . VAL B 2 20  ? 152.924 137.918 106.787 1.00 12.08 ? 20  VAL B CB  1 
ATOM   3510 C CG1 . VAL B 2 20  ? 153.003 136.718 105.868 1.00 12.08 ? 20  VAL B CG1 1 
ATOM   3511 C CG2 . VAL B 2 20  ? 152.991 137.462 108.225 1.00 12.08 ? 20  VAL B CG2 1 
ATOM   3512 N N   . PRO B 2 21  ? 153.574 141.291 106.287 1.00 11.63 ? 21  PRO B N   1 
ATOM   3513 C CA  . PRO B 2 21  ? 153.277 142.614 106.848 1.00 11.63 ? 21  PRO B CA  1 
ATOM   3514 C C   . PRO B 2 21  ? 152.002 142.594 107.676 1.00 11.63 ? 21  PRO B C   1 
ATOM   3515 O O   . PRO B 2 21  ? 151.035 141.905 107.348 1.00 11.63 ? 21  PRO B O   1 
ATOM   3516 C CB  . PRO B 2 21  ? 153.129 143.500 105.607 1.00 11.63 ? 21  PRO B CB  1 
ATOM   3517 C CG  . PRO B 2 21  ? 153.865 142.775 104.529 1.00 11.63 ? 21  PRO B CG  1 
ATOM   3518 C CD  . PRO B 2 21  ? 153.673 141.320 104.819 1.00 11.63 ? 21  PRO B CD  1 
ATOM   3519 N N   . PHE B 2 22  ? 152.011 143.360 108.757 1.00 7.33  ? 22  PHE B N   1 
ATOM   3520 C CA  . PHE B 2 22  ? 150.850 143.454 109.632 1.00 7.33  ? 22  PHE B CA  1 
ATOM   3521 C C   . PHE B 2 22  ? 149.814 144.386 109.014 1.00 7.33  ? 22  PHE B C   1 
ATOM   3522 O O   . PHE B 2 22  ? 150.149 145.527 108.677 1.00 7.33  ? 22  PHE B O   1 
ATOM   3523 C CB  . PHE B 2 22  ? 151.266 143.966 111.007 1.00 7.33  ? 22  PHE B CB  1 
ATOM   3524 C CG  . PHE B 2 22  ? 150.145 144.015 112.008 1.00 7.33  ? 22  PHE B CG  1 
ATOM   3525 C CD1 . PHE B 2 22  ? 150.042 145.071 112.897 1.00 7.33  ? 22  PHE B CD1 1 
ATOM   3526 C CD2 . PHE B 2 22  ? 149.208 143.001 112.074 1.00 7.33  ? 22  PHE B CD2 1 
ATOM   3527 C CE1 . PHE B 2 22  ? 149.016 145.121 113.821 1.00 7.33  ? 22  PHE B CE1 1 
ATOM   3528 C CE2 . PHE B 2 22  ? 148.182 143.046 112.998 1.00 7.33  ? 22  PHE B CE2 1 
ATOM   3529 C CZ  . PHE B 2 22  ? 148.086 144.106 113.871 1.00 7.33  ? 22  PHE B CZ  1 
ATOM   3530 N N   . PRO B 2 23  ? 148.575 143.945 108.822 1.00 6.46  ? 23  PRO B N   1 
ATOM   3531 C CA  . PRO B 2 23  ? 147.522 144.860 108.381 1.00 6.46  ? 23  PRO B CA  1 
ATOM   3532 C C   . PRO B 2 23  ? 147.334 145.990 109.377 1.00 6.46  ? 23  PRO B C   1 
ATOM   3533 O O   . PRO B 2 23  ? 147.187 145.742 110.583 1.00 6.46  ? 23  PRO B O   1 
ATOM   3534 C CB  . PRO B 2 23  ? 146.279 143.961 108.322 1.00 6.46  ? 23  PRO B CB  1 
ATOM   3535 C CG  . PRO B 2 23  ? 146.821 142.607 108.075 1.00 6.46  ? 23  PRO B CG  1 
ATOM   3536 C CD  . PRO B 2 23  ? 148.125 142.544 108.813 1.00 6.46  ? 23  PRO B CD  1 
ATOM   3537 N N   . PRO B 2 24  ? 147.347 147.241 108.916 1.00 6.95  ? 24  PRO B N   1 
ATOM   3538 C CA  . PRO B 2 24  ? 147.094 148.365 109.825 1.00 6.95  ? 24  PRO B CA  1 
ATOM   3539 C C   . PRO B 2 24  ? 145.725 148.261 110.479 1.00 6.95  ? 24  PRO B C   1 
ATOM   3540 O O   . PRO B 2 24  ? 144.741 147.871 109.848 1.00 6.95  ? 24  PRO B O   1 
ATOM   3541 C CB  . PRO B 2 24  ? 147.189 149.586 108.907 1.00 6.95  ? 24  PRO B CB  1 
ATOM   3542 C CG  . PRO B 2 24  ? 148.097 149.150 107.817 1.00 6.95  ? 24  PRO B CG  1 
ATOM   3543 C CD  . PRO B 2 24  ? 147.798 147.697 107.592 1.00 6.95  ? 24  PRO B CD  1 
ATOM   3544 N N   . SER B 2 25  ? 145.670 148.624 111.759 1.00 10.87 ? 25  SER B N   1 
ATOM   3545 C CA  . SER B 2 25  ? 144.481 148.435 112.576 1.00 10.87 ? 25  SER B CA  1 
ATOM   3546 C C   . SER B 2 25  ? 143.663 149.703 112.770 1.00 10.87 ? 25  SER B C   1 
ATOM   3547 O O   . SER B 2 25  ? 142.619 149.650 113.427 1.00 10.87 ? 25  SER B O   1 
ATOM   3548 C CB  . SER B 2 25  ? 144.871 147.873 113.946 1.00 10.87 ? 25  SER B CB  1 
ATOM   3549 O OG  . SER B 2 25  ? 143.764 147.879 114.829 1.00 10.87 ? 25  SER B OG  1 
ATOM   3550 N N   . HIS B 2 26  ? 144.097 150.834 112.221 1.00 14.01 ? 26  HIS B N   1 
ATOM   3551 C CA  . HIS B 2 26  ? 143.424 152.109 112.427 1.00 14.01 ? 26  HIS B CA  1 
ATOM   3552 C C   . HIS B 2 26  ? 142.726 152.543 111.146 1.00 14.01 ? 26  HIS B C   1 
ATOM   3553 O O   . HIS B 2 26  ? 143.326 152.520 110.066 1.00 14.01 ? 26  HIS B O   1 
ATOM   3554 C CB  . HIS B 2 26  ? 144.409 153.187 112.888 1.00 14.01 ? 26  HIS B CB  1 
ATOM   3555 C CG  . HIS B 2 26  ? 145.399 153.595 111.843 1.00 14.01 ? 26  HIS B CG  1 
ATOM   3556 N ND1 . HIS B 2 26  ? 146.379 152.748 111.374 1.00 14.01 ? 26  HIS B ND1 1 
ATOM   3557 C CD2 . HIS B 2 26  ? 145.561 154.762 111.177 1.00 14.01 ? 26  HIS B CD2 1 
ATOM   3558 C CE1 . HIS B 2 26  ? 147.102 153.376 110.464 1.00 14.01 ? 26  HIS B CE1 1 
ATOM   3559 N NE2 . HIS B 2 26  ? 146.626 154.600 110.326 1.00 14.01 ? 26  HIS B NE2 1 
ATOM   3560 N N   . ARG B 2 27  ? 141.460 152.924 111.270 1.00 14.42 ? 27  ARG B N   1 
ATOM   3561 C CA  . ARG B 2 27  ? 140.711 153.452 110.144 1.00 14.42 ? 27  ARG B CA  1 
ATOM   3562 C C   . ARG B 2 27  ? 141.017 154.935 109.959 1.00 14.42 ? 27  ARG B C   1 
ATOM   3563 O O   . ARG B 2 27  ? 141.550 155.602 110.849 1.00 14.42 ? 27  ARG B O   1 
ATOM   3564 C CB  . ARG B 2 27  ? 139.212 153.238 110.350 1.00 14.42 ? 27  ARG B CB  1 
ATOM   3565 C CG  . ARG B 2 27  ? 138.808 151.774 110.410 1.00 14.42 ? 27  ARG B CG  1 
ATOM   3566 C CD  . ARG B 2 27  ? 137.301 151.608 110.504 1.00 14.42 ? 27  ARG B CD  1 
ATOM   3567 N NE  . ARG B 2 27  ? 136.913 150.201 110.502 1.00 14.42 ? 27  ARG B NE  1 
ATOM   3568 C CZ  . ARG B 2 27  ? 135.658 149.771 110.575 1.00 14.42 ? 27  ARG B CZ  1 
ATOM   3569 N NH1 . ARG B 2 27  ? 134.659 150.638 110.655 1.00 14.42 ? 27  ARG B NH1 1 
ATOM   3570 N NH2 . ARG B 2 27  ? 135.400 148.471 110.567 1.00 14.42 ? 27  ARG B NH2 1 
ATOM   3571 N N   . LEU B 2 28  ? 140.676 155.450 108.782 1.00 12.25 ? 28  LEU B N   1 
ATOM   3572 C CA  . LEU B 2 28  ? 140.952 156.836 108.429 1.00 12.25 ? 28  LEU B CA  1 
ATOM   3573 C C   . LEU B 2 28  ? 139.674 157.654 108.567 1.00 12.25 ? 28  LEU B C   1 
ATOM   3574 O O   . LEU B 2 28  ? 138.666 157.353 107.921 1.00 12.25 ? 28  LEU B O   1 
ATOM   3575 C CB  . LEU B 2 28  ? 141.513 156.931 107.012 1.00 12.25 ? 28  LEU B CB  1 
ATOM   3576 C CG  . LEU B 2 28  ? 142.898 156.297 106.866 1.00 12.25 ? 28  LEU B CG  1 
ATOM   3577 C CD1 . LEU B 2 28  ? 143.508 156.595 105.510 1.00 12.25 ? 28  LEU B CD1 1 
ATOM   3578 C CD2 . LEU B 2 28  ? 143.816 156.765 107.980 1.00 12.25 ? 28  LEU B CD2 1 
ATOM   3579 N N   . THR B 2 29  ? 139.720 158.680 109.413 1.00 16.79 ? 29  THR B N   1 
ATOM   3580 C CA  . THR B 2 29  ? 138.560 159.524 109.702 1.00 16.79 ? 29  THR B CA  1 
ATOM   3581 C C   . THR B 2 29  ? 138.528 160.773 108.825 1.00 16.79 ? 29  THR B C   1 
ATOM   3582 O O   . THR B 2 29  ? 138.423 161.894 109.318 1.00 16.79 ? 29  THR B O   1 
ATOM   3583 C CB  . THR B 2 29  ? 138.551 159.901 111.178 1.00 16.79 ? 29  THR B CB  1 
ATOM   3584 O OG1 . THR B 2 29  ? 139.564 160.883 111.426 1.00 16.79 ? 29  THR B OG1 1 
ATOM   3585 C CG2 . THR B 2 29  ? 138.822 158.680 112.042 1.00 16.79 ? 29  THR B CG2 1 
ATOM   3586 N N   . ALA B 2 30  ? 138.625 160.583 107.510 1.00 15.25 ? 30  ALA B N   1 
ATOM   3587 C CA  . ALA B 2 30  ? 138.525 161.640 106.506 1.00 15.25 ? 30  ALA B CA  1 
ATOM   3588 C C   . ALA B 2 30  ? 139.577 162.727 106.672 1.00 15.25 ? 30  ALA B C   1 
ATOM   3589 O O   . ALA B 2 30  ? 139.503 163.759 105.997 1.00 15.25 ? 30  ALA B O   1 
ATOM   3590 C CB  . ALA B 2 30  ? 137.129 162.278 106.498 1.00 15.25 ? 30  ALA B CB  1 
ATOM   3591 N N   . LYS B 2 31  ? 140.556 162.530 107.552 1.00 16.56 ? 31  LYS B N   1 
ATOM   3592 C CA  . LYS B 2 31  ? 141.549 163.571 107.785 1.00 16.56 ? 31  LYS B CA  1 
ATOM   3593 C C   . LYS B 2 31  ? 142.549 163.659 106.640 1.00 16.56 ? 31  LYS B C   1 
ATOM   3594 O O   . LYS B 2 31  ? 142.929 164.760 106.228 1.00 16.56 ? 31  LYS B O   1 
ATOM   3595 C CB  . LYS B 2 31  ? 142.273 163.320 109.108 1.00 16.56 ? 31  LYS B CB  1 
ATOM   3596 N N   . GLU B 2 32  ? 142.979 162.517 106.115 1.00 14.25 ? 32  GLU B N   1 
ATOM   3597 C CA  . GLU B 2 32  ? 144.016 162.468 105.091 1.00 14.25 ? 32  GLU B CA  1 
ATOM   3598 C C   . GLU B 2 32  ? 143.483 162.181 103.698 1.00 14.25 ? 32  GLU B C   1 
ATOM   3599 O O   . GLU B 2 32  ? 143.967 162.768 102.728 1.00 14.25 ? 32  GLU B O   1 
ATOM   3600 C CB  . GLU B 2 32  ? 145.063 161.410 105.458 1.00 14.25 ? 32  GLU B CB  1 
ATOM   3601 C CG  . GLU B 2 32  ? 145.482 161.436 106.918 1.00 14.25 ? 32  GLU B CG  1 
ATOM   3602 C CD  . GLU B 2 32  ? 144.667 160.490 107.777 1.00 14.25 ? 32  GLU B CD  1 
ATOM   3603 O OE1 . GLU B 2 32  ? 145.267 159.618 108.438 1.00 14.25 ? 32  GLU B OE1 1 
ATOM   3604 O OE2 . GLU B 2 32  ? 143.425 160.621 107.790 1.00 14.25 ? 32  GLU B OE2 1 
ATOM   3605 N N   . VAL B 2 33  ? 142.488 161.298 103.572 1.00 14.48 ? 33  VAL B N   1 
ATOM   3606 C CA  . VAL B 2 33  ? 141.997 160.888 102.261 1.00 14.48 ? 33  VAL B CA  1 
ATOM   3607 C C   . VAL B 2 33  ? 141.257 161.991 101.522 1.00 14.48 ? 33  VAL B C   1 
ATOM   3608 O O   . VAL B 2 33  ? 140.880 161.795 100.362 1.00 14.48 ? 33  VAL B O   1 
ATOM   3609 C CB  . VAL B 2 33  ? 141.079 159.656 102.388 1.00 14.48 ? 33  VAL B CB  1 
ATOM   3610 C CG1 . VAL B 2 33  ? 141.848 158.487 102.963 1.00 14.48 ? 33  VAL B CG1 1 
ATOM   3611 C CG2 . VAL B 2 33  ? 139.874 159.981 103.251 1.00 14.48 ? 33  VAL B CG2 1 
ATOM   3612 N N   . PHE B 2 34  ? 141.033 163.138 102.155 1.00 16.77 ? 34  PHE B N   1 
ATOM   3613 C CA  . PHE B 2 34  ? 140.354 164.262 101.530 1.00 16.77 ? 34  PHE B CA  1 
ATOM   3614 C C   . PHE B 2 34  ? 141.213 165.513 101.643 1.00 16.77 ? 34  PHE B C   1 
ATOM   3615 O O   . PHE B 2 34  ? 141.800 165.783 102.696 1.00 16.77 ? 34  PHE B O   1 
ATOM   3616 C CB  . PHE B 2 34  ? 138.984 164.505 102.171 1.00 16.77 ? 34  PHE B CB  1 
ATOM   3617 C CG  . PHE B 2 34  ? 137.868 163.748 101.514 1.00 16.77 ? 34  PHE B CG  1 
ATOM   3618 C CD1 . PHE B 2 34  ? 137.402 164.120 100.265 1.00 16.77 ? 34  PHE B CD1 1 
ATOM   3619 C CD2 . PHE B 2 34  ? 137.291 162.658 102.141 1.00 16.77 ? 34  PHE B CD2 1 
ATOM   3620 C CE1 . PHE B 2 34  ? 136.376 163.423 99.657  1.00 16.77 ? 34  PHE B CE1 1 
ATOM   3621 C CE2 . PHE B 2 34  ? 136.267 161.957 101.538 1.00 16.77 ? 34  PHE B CE2 1 
ATOM   3622 C CZ  . PHE B 2 34  ? 135.809 162.341 100.294 1.00 16.77 ? 34  PHE B CZ  1 
ATOM   3623 N N   . ASP B 2 35  ? 141.283 166.272 100.554 1.00 17.60 ? 35  ASP B N   1 
ATOM   3624 C CA  . ASP B 2 35  ? 142.036 167.520 100.534 1.00 17.60 ? 35  ASP B CA  1 
ATOM   3625 C C   . ASP B 2 35  ? 141.129 168.692 100.180 1.00 17.60 ? 35  ASP B C   1 
ATOM   3626 O O   . ASP B 2 35  ? 140.165 168.539 99.431  1.00 17.60 ? 35  ASP B O   1 
ATOM   3627 C CB  . ASP B 2 35  ? 143.195 167.435 99.540  1.00 17.60 ? 35  ASP B CB  1 
ATOM   3628 C CG  . ASP B 2 35  ? 144.376 166.664 100.089 1.00 17.60 ? 35  ASP B CG  1 
ATOM   3629 O OD1 . ASP B 2 35  ? 144.210 165.969 101.113 1.00 17.60 ? 35  ASP B OD1 1 
ATOM   3630 O OD2 . ASP B 2 35  ? 145.472 166.753 99.498  1.00 17.60 ? 35  ASP B OD2 1 
ATOM   3631 N N   . GLY B 2 38  ? 134.834 167.993 98.435  1.00 16.61 ? 38  GLY B N   1 
ATOM   3632 C CA  . GLY B 2 38  ? 136.260 168.218 98.296  1.00 16.61 ? 38  GLY B CA  1 
ATOM   3633 C C   . GLY B 2 38  ? 136.970 167.097 97.565  1.00 16.61 ? 38  GLY B C   1 
ATOM   3634 O O   . GLY B 2 38  ? 136.629 165.926 97.729  1.00 16.61 ? 38  GLY B O   1 
ATOM   3635 N N   . LYS B 2 39  ? 137.956 167.458 96.754  1.00 16.19 ? 39  LYS B N   1 
ATOM   3636 C CA  . LYS B 2 39  ? 138.695 166.462 95.994  1.00 16.19 ? 39  LYS B CA  1 
ATOM   3637 C C   . LYS B 2 39  ? 139.466 165.551 96.943  1.00 16.19 ? 39  LYS B C   1 
ATOM   3638 O O   . LYS B 2 39  ? 140.142 166.045 97.855  1.00 16.19 ? 39  LYS B O   1 
ATOM   3639 C CB  . LYS B 2 39  ? 139.652 167.138 95.015  1.00 16.19 ? 39  LYS B CB  1 
ATOM   3640 C CG  . LYS B 2 39  ? 138.965 168.047 94.014  1.00 16.19 ? 39  LYS B CG  1 
ATOM   3641 C CD  . LYS B 2 39  ? 139.950 168.587 92.997  1.00 16.19 ? 39  LYS B CD  1 
ATOM   3642 C CE  . LYS B 2 39  ? 139.237 169.350 91.895  1.00 16.19 ? 39  LYS B CE  1 
ATOM   3643 N NZ  . LYS B 2 39  ? 140.190 169.861 90.872  1.00 16.19 ? 39  LYS B NZ  1 
ATOM   3644 N N   . PRO B 2 40  ? 139.388 164.234 96.774  1.00 16.13 ? 40  PRO B N   1 
ATOM   3645 C CA  . PRO B 2 40  ? 140.103 163.319 97.664  1.00 16.13 ? 40  PRO B CA  1 
ATOM   3646 C C   . PRO B 2 40  ? 141.526 163.050 97.194  1.00 16.13 ? 40  PRO B C   1 
ATOM   3647 O O   . PRO B 2 40  ? 141.937 163.432 96.097  1.00 16.13 ? 40  PRO B O   1 
ATOM   3648 C CB  . PRO B 2 40  ? 139.255 162.043 97.591  1.00 16.13 ? 40  PRO B CB  1 
ATOM   3649 C CG  . PRO B 2 40  ? 138.665 162.074 96.215  1.00 16.13 ? 40  PRO B CG  1 
ATOM   3650 C CD  . PRO B 2 40  ? 138.618 163.512 95.748  1.00 16.13 ? 40  PRO B CD  1 
ATOM   3651 N N   . ARG B 2 41  ? 142.280 162.384 98.063  1.00 15.71 ? 41  ARG B N   1 
ATOM   3652 C CA  . ARG B 2 41  ? 143.638 161.975 97.733  1.00 15.71 ? 41  ARG B CA  1 
ATOM   3653 C C   . ARG B 2 41  ? 143.641 160.522 97.273  1.00 15.71 ? 41  ARG B C   1 
ATOM   3654 O O   . ARG B 2 41  ? 143.101 159.644 97.953  1.00 15.71 ? 41  ARG B O   1 
ATOM   3655 C CB  . ARG B 2 41  ? 144.560 162.159 98.937  1.00 15.71 ? 41  ARG B CB  1 
ATOM   3656 N N   . VAL B 2 42  ? 144.250 160.272 96.121  1.00 11.43 ? 42  VAL B N   1 
ATOM   3657 C CA  . VAL B 2 42  ? 144.241 158.955 95.497  1.00 11.43 ? 42  VAL B CA  1 
ATOM   3658 C C   . VAL B 2 42  ? 145.451 158.129 95.907  1.00 11.43 ? 42  VAL B C   1 
ATOM   3659 O O   . VAL B 2 42  ? 145.316 156.961 96.271  1.00 11.43 ? 42  VAL B O   1 
ATOM   3660 C CB  . VAL B 2 42  ? 144.154 159.095 93.962  1.00 11.43 ? 42  VAL B CB  1 
ATOM   3661 C CG1 . VAL B 2 42  ? 144.606 157.817 93.283  1.00 11.43 ? 42  VAL B CG1 1 
ATOM   3662 C CG2 . VAL B 2 42  ? 142.740 159.439 93.550  1.00 11.43 ? 42  VAL B CG2 1 
ATOM   3663 N N   . ASP B 2 43  ? 146.645 158.724 95.858  1.00 9.85  ? 43  ASP B N   1 
ATOM   3664 C CA  . ASP B 2 43  ? 147.865 157.957 96.090  1.00 9.85  ? 43  ASP B CA  1 
ATOM   3665 C C   . ASP B 2 43  ? 147.890 157.355 97.489  1.00 9.85  ? 43  ASP B C   1 
ATOM   3666 O O   . ASP B 2 43  ? 148.258 156.186 97.663  1.00 9.85  ? 43  ASP B O   1 
ATOM   3667 C CB  . ASP B 2 43  ? 149.087 158.843 95.864  1.00 9.85  ? 43  ASP B CB  1 
ATOM   3668 C CG  . ASP B 2 43  ? 149.252 159.244 94.414  1.00 9.85  ? 43  ASP B CG  1 
ATOM   3669 O OD1 . ASP B 2 43  ? 148.805 158.480 93.533  1.00 9.85  ? 43  ASP B OD1 1 
ATOM   3670 O OD2 . ASP B 2 43  ? 149.821 160.325 94.156  1.00 9.85  ? 43  ASP B OD2 1 
ATOM   3671 N N   . ILE B 2 44  ? 147.500 158.133 98.499  1.00 10.23 ? 44  ILE B N   1 
ATOM   3672 C CA  . ILE B 2 44  ? 147.477 157.590 99.852  1.00 10.23 ? 44  ILE B CA  1 
ATOM   3673 C C   . ILE B 2 44  ? 146.370 156.554 100.002 1.00 10.23 ? 44  ILE B C   1 
ATOM   3674 O O   . ILE B 2 44  ? 146.537 155.569 100.726 1.00 10.23 ? 44  ILE B O   1 
ATOM   3675 C CB  . ILE B 2 44  ? 147.357 158.717 100.893 1.00 10.23 ? 44  ILE B CB  1 
ATOM   3676 C CG1 . ILE B 2 44  ? 145.955 159.319 100.897 1.00 10.23 ? 44  ILE B CG1 1 
ATOM   3677 C CG2 . ILE B 2 44  ? 148.400 159.791 100.631 1.00 10.23 ? 44  ILE B CG2 1 
ATOM   3678 C CD1 . ILE B 2 44  ? 145.690 160.185 102.090 1.00 10.23 ? 44  ILE B CD1 1 
ATOM   3679 N N   . LEU B 2 45  ? 145.232 156.741 99.326  1.00 7.82  ? 45  LEU B N   1 
ATOM   3680 C CA  . LEU B 2 45  ? 144.181 155.726 99.366  1.00 7.82  ? 45  LEU B CA  1 
ATOM   3681 C C   . LEU B 2 45  ? 144.659 154.419 98.749  1.00 7.82  ? 45  LEU B C   1 
ATOM   3682 O O   . LEU B 2 45  ? 144.394 153.336 99.284  1.00 7.82  ? 45  LEU B O   1 
ATOM   3683 C CB  . LEU B 2 45  ? 142.930 156.229 98.649  1.00 7.82  ? 45  LEU B CB  1 
ATOM   3684 C CG  . LEU B 2 45  ? 141.640 155.475 98.963  1.00 7.82  ? 45  LEU B CG  1 
ATOM   3685 C CD1 . LEU B 2 45  ? 141.412 155.412 100.460 1.00 7.82  ? 45  LEU B CD1 1 
ATOM   3686 C CD2 . LEU B 2 45  ? 140.465 156.134 98.273  1.00 7.82  ? 45  LEU B CD2 1 
ATOM   3687 N N   . LYS B 2 46  ? 145.367 154.502 97.622  1.00 5.45  ? 46  LYS B N   1 
ATOM   3688 C CA  . LYS B 2 46  ? 145.948 153.308 97.025  1.00 5.45  ? 46  LYS B CA  1 
ATOM   3689 C C   . LYS B 2 46  ? 146.927 152.643 97.981  1.00 5.45  ? 46  LYS B C   1 
ATOM   3690 O O   . LYS B 2 46  ? 146.851 151.434 98.222  1.00 5.45  ? 46  LYS B O   1 
ATOM   3691 C CB  . LYS B 2 46  ? 146.644 153.661 95.711  1.00 5.45  ? 46  LYS B CB  1 
ATOM   3692 C CG  . LYS B 2 46  ? 147.717 152.664 95.308  1.00 5.45  ? 46  LYS B CG  1 
ATOM   3693 C CD  . LYS B 2 46  ? 148.549 153.165 94.142  1.00 5.45  ? 46  LYS B CD  1 
ATOM   3694 C CE  . LYS B 2 46  ? 147.812 153.011 92.825  1.00 5.45  ? 46  LYS B CE  1 
ATOM   3695 N NZ  . LYS B 2 46  ? 148.718 153.205 91.661  1.00 5.45  ? 46  LYS B NZ  1 
ATOM   3696 N N   . ALA B 2 47  ? 147.853 153.423 98.546  1.00 4.70  ? 47  ALA B N   1 
ATOM   3697 C CA  . ALA B 2 47  ? 148.882 152.847 99.404  1.00 4.70  ? 47  ALA B CA  1 
ATOM   3698 C C   . ALA B 2 47  ? 148.331 152.375 100.742 1.00 4.70  ? 47  ALA B C   1 
ATOM   3699 O O   . ALA B 2 47  ? 149.013 151.628 101.450 1.00 4.70  ? 47  ALA B O   1 
ATOM   3700 C CB  . ALA B 2 47  ? 150.005 153.859 99.631  1.00 4.70  ? 47  ALA B CB  1 
ATOM   3701 N N   . HIS B 2 48  ? 147.125 152.800 101.107 1.00 5.41  ? 48  HIS B N   1 
ATOM   3702 C CA  . HIS B 2 48  ? 146.485 152.342 102.331 1.00 5.41  ? 48  HIS B CA  1 
ATOM   3703 C C   . HIS B 2 48  ? 145.665 151.079 102.100 1.00 5.41  ? 48  HIS B C   1 
ATOM   3704 O O   . HIS B 2 48  ? 145.699 150.157 102.921 1.00 5.41  ? 48  HIS B O   1 
ATOM   3705 C CB  . HIS B 2 48  ? 145.596 153.450 102.898 1.00 5.41  ? 48  HIS B CB  1 
ATOM   3706 C CG  . HIS B 2 48  ? 144.812 153.041 104.104 1.00 5.41  ? 48  HIS B CG  1 
ATOM   3707 N ND1 . HIS B 2 48  ? 145.357 152.301 105.131 1.00 5.41  ? 48  HIS B ND1 1 
ATOM   3708 C CD2 . HIS B 2 48  ? 143.523 153.269 104.448 1.00 5.41  ? 48  HIS B CD2 1 
ATOM   3709 C CE1 . HIS B 2 48  ? 144.438 152.095 106.056 1.00 5.41  ? 48  HIS B CE1 1 
ATOM   3710 N NE2 . HIS B 2 48  ? 143.315 152.669 105.665 1.00 5.41  ? 48  HIS B NE2 1 
ATOM   3711 N N   . LEU B 2 49  ? 144.920 151.022 100.992 1.00 3.48  ? 49  LEU B N   1 
ATOM   3712 C CA  . LEU B 2 49  ? 144.107 149.842 100.719 1.00 3.48  ? 49  LEU B CA  1 
ATOM   3713 C C   . LEU B 2 49  ? 144.938 148.704 100.144 1.00 3.48  ? 49  LEU B C   1 
ATOM   3714 O O   . LEU B 2 49  ? 144.501 147.550 100.174 1.00 3.48  ? 49  LEU B O   1 
ATOM   3715 C CB  . LEU B 2 49  ? 142.959 150.196 99.778  1.00 3.48  ? 49  LEU B CB  1 
ATOM   3716 C CG  . LEU B 2 49  ? 141.764 150.856 100.463 1.00 3.48  ? 49  LEU B CG  1 
ATOM   3717 C CD1 . LEU B 2 49  ? 140.736 151.298 99.446  1.00 3.48  ? 49  LEU B CD1 1 
ATOM   3718 C CD2 . LEU B 2 49  ? 141.147 149.912 101.472 1.00 3.48  ? 49  LEU B CD2 1 
ATOM   3719 N N   . MET B 2 50  ? 146.134 148.996 99.629  1.00 3.72  ? 50  MET B N   1 
ATOM   3720 C CA  . MET B 2 50  ? 146.990 147.933 99.123  1.00 3.72  ? 50  MET B CA  1 
ATOM   3721 C C   . MET B 2 50  ? 147.654 147.154 100.252 1.00 3.72  ? 50  MET B C   1 
ATOM   3722 O O   . MET B 2 50  ? 148.237 146.093 100.005 1.00 3.72  ? 50  MET B O   1 
ATOM   3723 C CB  . MET B 2 50  ? 148.032 148.529 98.173  1.00 3.72  ? 50  MET B CB  1 
ATOM   3724 C CG  . MET B 2 50  ? 148.919 147.520 97.471  1.00 3.72  ? 50  MET B CG  1 
ATOM   3725 S SD  . MET B 2 50  ? 150.106 148.296 96.364  1.00 3.72  ? 50  MET B SD  1 
ATOM   3726 C CE  . MET B 2 50  ? 149.019 148.829 95.047  1.00 3.72  ? 50  MET B CE  1 
ATOM   3727 N N   . LYS B 2 51  ? 147.563 147.642 101.488 1.00 4.73  ? 51  LYS B N   1 
ATOM   3728 C CA  . LYS B 2 51  ? 148.091 146.945 102.653 1.00 4.73  ? 51  LYS B CA  1 
ATOM   3729 C C   . LYS B 2 51  ? 146.985 146.368 103.527 1.00 4.73  ? 51  LYS B C   1 
ATOM   3730 O O   . LYS B 2 51  ? 147.176 146.200 104.735 1.00 4.73  ? 51  LYS B O   1 
ATOM   3731 C CB  . LYS B 2 51  ? 148.977 147.881 103.474 1.00 4.73  ? 51  LYS B CB  1 
ATOM   3732 C CG  . LYS B 2 51  ? 150.338 148.152 102.859 1.00 4.73  ? 51  LYS B CG  1 
ATOM   3733 C CD  . LYS B 2 51  ? 151.187 149.022 103.767 1.00 4.73  ? 51  LYS B CD  1 
ATOM   3734 C CE  . LYS B 2 51  ? 152.566 149.254 103.175 1.00 4.73  ? 51  LYS B CE  1 
ATOM   3735 N NZ  . LYS B 2 51  ? 153.349 147.993 103.079 1.00 4.73  ? 51  LYS B NZ  1 
ATOM   3736 N N   . GLU B 2 52  ? 145.831 146.059 102.936 1.00 4.44  ? 52  GLU B N   1 
ATOM   3737 C CA  . GLU B 2 52  ? 144.661 145.590 103.679 1.00 4.44  ? 52  GLU B CA  1 
ATOM   3738 C C   . GLU B 2 52  ? 144.307 146.532 104.820 1.00 4.44  ? 52  GLU B C   1 
ATOM   3739 O O   . GLU B 2 52  ? 143.974 146.106 105.926 1.00 4.44  ? 52  GLU B O   1 
ATOM   3740 C CB  . GLU B 2 52  ? 144.850 144.168 104.204 1.00 4.44  ? 52  GLU B CB  1 
ATOM   3741 C CG  . GLU B 2 52  ? 144.963 143.108 103.140 1.00 4.44  ? 52  GLU B CG  1 
ATOM   3742 C CD  . GLU B 2 52  ? 144.256 141.838 103.557 1.00 4.44  ? 52  GLU B CD  1 
ATOM   3743 O OE1 . GLU B 2 52  ? 143.559 141.864 104.591 1.00 4.44  ? 52  GLU B OE1 1 
ATOM   3744 O OE2 . GLU B 2 52  ? 144.373 140.822 102.850 1.00 4.44  ? 52  GLU B OE2 1 
ATOM   3745 N N   . GLY B 2 53  ? 144.365 147.828 104.548 1.00 4.98  ? 53  GLY B N   1 
ATOM   3746 C CA  . GLY B 2 53  ? 143.928 148.792 105.532 1.00 4.98  ? 53  GLY B CA  1 
ATOM   3747 C C   . GLY B 2 53  ? 142.423 148.799 105.680 1.00 4.98  ? 53  GLY B C   1 
ATOM   3748 O O   . GLY B 2 53  ? 141.757 147.799 105.400 1.00 4.98  ? 53  GLY B O   1 
ATOM   3749 N N   . ARG B 2 54  ? 141.871 149.923 106.122 1.00 9.02  ? 54  ARG B N   1 
ATOM   3750 C CA  . ARG B 2 54  ? 140.429 150.046 106.250 1.00 9.02  ? 54  ARG B CA  1 
ATOM   3751 C C   . ARG B 2 54  ? 140.080 151.524 106.313 1.00 9.02  ? 54  ARG B C   1 
ATOM   3752 O O   . ARG B 2 54  ? 140.948 152.378 106.507 1.00 9.02  ? 54  ARG B O   1 
ATOM   3753 C CB  . ARG B 2 54  ? 139.915 149.299 107.484 1.00 9.02  ? 54  ARG B CB  1 
ATOM   3754 C CG  . ARG B 2 54  ? 138.503 148.769 107.351 1.00 9.02  ? 54  ARG B CG  1 
ATOM   3755 C CD  . ARG B 2 54  ? 138.380 147.408 108.009 1.00 9.02  ? 54  ARG B CD  1 
ATOM   3756 N NE  . ARG B 2 54  ? 138.439 147.497 109.464 1.00 9.02  ? 54  ARG B NE  1 
ATOM   3757 C CZ  . ARG B 2 54  ? 138.459 146.445 110.276 1.00 9.02  ? 54  ARG B CZ  1 
ATOM   3758 N NH1 . ARG B 2 54  ? 138.425 145.219 109.774 1.00 9.02  ? 54  ARG B NH1 1 
ATOM   3759 N NH2 . ARG B 2 54  ? 138.515 146.618 111.589 1.00 9.02  ? 54  ARG B NH2 1 
ATOM   3760 N N   . LEU B 2 55  ? 138.797 151.815 106.126 1.00 10.11 ? 55  LEU B N   1 
ATOM   3761 C CA  . LEU B 2 55  ? 138.285 153.173 106.198 1.00 10.11 ? 55  LEU B CA  1 
ATOM   3762 C C   . LEU B 2 55  ? 137.106 153.213 107.158 1.00 10.11 ? 55  LEU B C   1 
ATOM   3763 O O   . LEU B 2 55  ? 136.416 152.212 107.361 1.00 10.11 ? 55  LEU B O   1 
ATOM   3764 C CB  . LEU B 2 55  ? 137.857 153.691 104.821 1.00 10.11 ? 55  LEU B CB  1 
ATOM   3765 C CG  . LEU B 2 55  ? 138.846 154.604 104.097 1.00 10.11 ? 55  LEU B CG  1 
ATOM   3766 C CD1 . LEU B 2 55  ? 140.115 153.850 103.752 1.00 10.11 ? 55  LEU B CD1 1 
ATOM   3767 C CD2 . LEU B 2 55  ? 138.222 155.205 102.850 1.00 10.11 ? 55  LEU B CD2 1 
ATOM   3768 N N   . GLU B 2 56  ? 136.888 154.381 107.753 1.00 12.27 ? 56  GLU B N   1 
ATOM   3769 C CA  . GLU B 2 56  ? 135.754 154.558 108.644 1.00 12.27 ? 56  GLU B CA  1 
ATOM   3770 C C   . GLU B 2 56  ? 134.451 154.454 107.863 1.00 12.27 ? 56  GLU B C   1 
ATOM   3771 O O   . GLU B 2 56  ? 134.404 154.700 106.655 1.00 12.27 ? 56  GLU B O   1 
ATOM   3772 C CB  . GLU B 2 56  ? 135.836 155.908 109.354 1.00 12.27 ? 56  GLU B CB  1 
ATOM   3773 N N   . GLU B 2 57  ? 133.384 154.072 108.568 1.00 13.41 ? 57  GLU B N   1 
ATOM   3774 C CA  . GLU B 2 57  ? 132.094 153.889 107.912 1.00 13.41 ? 57  GLU B CA  1 
ATOM   3775 C C   . GLU B 2 57  ? 131.601 155.188 107.288 1.00 13.41 ? 57  GLU B C   1 
ATOM   3776 O O   . GLU B 2 57  ? 131.104 155.193 106.154 1.00 13.41 ? 57  GLU B O   1 
ATOM   3777 C CB  . GLU B 2 57  ? 131.072 153.348 108.910 1.00 13.41 ? 57  GLU B CB  1 
ATOM   3778 C CG  . GLU B 2 57  ? 129.913 152.607 108.268 1.00 13.41 ? 57  GLU B CG  1 
ATOM   3779 C CD  . GLU B 2 57  ? 128.692 152.548 109.163 1.00 13.41 ? 57  GLU B CD  1 
ATOM   3780 O OE1 . GLU B 2 57  ? 128.829 152.131 110.331 1.00 13.41 ? 57  GLU B OE1 1 
ATOM   3781 O OE2 . GLU B 2 57  ? 127.594 152.918 108.698 1.00 13.41 ? 57  GLU B OE2 1 
ATOM   3782 N N   . SER B 2 58  ? 131.739 156.303 108.009 1.00 12.14 ? 58  SER B N   1 
ATOM   3783 C CA  . SER B 2 58  ? 131.281 157.585 107.484 1.00 12.14 ? 58  SER B CA  1 
ATOM   3784 C C   . SER B 2 58  ? 132.054 157.981 106.234 1.00 12.14 ? 58  SER B C   1 
ATOM   3785 O O   . SER B 2 58  ? 131.470 158.499 105.276 1.00 12.14 ? 58  SER B O   1 
ATOM   3786 C CB  . SER B 2 58  ? 131.407 158.667 108.555 1.00 12.14 ? 58  SER B CB  1 
ATOM   3787 O OG  . SER B 2 58  ? 131.028 159.932 108.041 1.00 12.14 ? 58  SER B OG  1 
ATOM   3788 N N   . VAL B 2 59  ? 133.367 157.750 106.223 1.00 11.92 ? 59  VAL B N   1 
ATOM   3789 C CA  . VAL B 2 59  ? 134.174 158.118 105.063 1.00 11.92 ? 59  VAL B CA  1 
ATOM   3790 C C   . VAL B 2 59  ? 133.781 157.286 103.847 1.00 11.92 ? 59  VAL B C   1 
ATOM   3791 O O   . VAL B 2 59  ? 133.659 157.809 102.731 1.00 11.92 ? 59  VAL B O   1 
ATOM   3792 C CB  . VAL B 2 59  ? 135.669 157.971 105.393 1.00 11.92 ? 59  VAL B CB  1 
ATOM   3793 C CG1 . VAL B 2 59  ? 136.523 158.387 104.204 1.00 11.92 ? 59  VAL B CG1 1 
ATOM   3794 C CG2 . VAL B 2 59  ? 136.013 158.781 106.624 1.00 11.92 ? 59  VAL B CG2 1 
ATOM   3795 N N   . ALA B 2 60  ? 133.584 155.979 104.037 1.00 11.56 ? 60  ALA B N   1 
ATOM   3796 C CA  . ALA B 2 60  ? 133.165 155.128 102.929 1.00 11.56 ? 60  ALA B CA  1 
ATOM   3797 C C   . ALA B 2 60  ? 131.797 155.543 102.404 1.00 11.56 ? 60  ALA B C   1 
ATOM   3798 O O   . ALA B 2 60  ? 131.582 155.602 101.186 1.00 11.56 ? 60  ALA B O   1 
ATOM   3799 C CB  . ALA B 2 60  ? 133.152 153.664 103.365 1.00 11.56 ? 60  ALA B CB  1 
ATOM   3800 N N   . LEU B 2 61  ? 130.859 155.838 103.309 1.00 11.96 ? 61  LEU B N   1 
ATOM   3801 C CA  . LEU B 2 61  ? 129.545 156.297 102.874 1.00 11.96 ? 61  LEU B CA  1 
ATOM   3802 C C   . LEU B 2 61  ? 129.648 157.611 102.113 1.00 11.96 ? 61  LEU B C   1 
ATOM   3803 O O   . LEU B 2 61  ? 128.951 157.809 101.114 1.00 11.96 ? 61  LEU B O   1 
ATOM   3804 C CB  . LEU B 2 61  ? 128.604 156.440 104.069 1.00 11.96 ? 61  LEU B CB  1 
ATOM   3805 C CG  . LEU B 2 61  ? 128.229 155.147 104.792 1.00 11.96 ? 61  LEU B CG  1 
ATOM   3806 C CD1 . LEU B 2 61  ? 127.407 155.444 106.036 1.00 11.96 ? 61  LEU B CD1 1 
ATOM   3807 C CD2 . LEU B 2 61  ? 127.475 154.217 103.859 1.00 11.96 ? 61  LEU B CD2 1 
ATOM   3808 N N   . ARG B 2 62  ? 130.520 158.515 102.561 1.00 12.53 ? 62  ARG B N   1 
ATOM   3809 C CA  . ARG B 2 62  ? 130.696 159.778 101.853 1.00 12.53 ? 62  ARG B CA  1 
ATOM   3810 C C   . ARG B 2 62  ? 131.251 159.558 100.453 1.00 12.53 ? 62  ARG B C   1 
ATOM   3811 O O   . ARG B 2 62  ? 130.773 160.167 99.488  1.00 12.53 ? 62  ARG B O   1 
ATOM   3812 C CB  . ARG B 2 62  ? 131.613 160.705 102.648 1.00 12.53 ? 62  ARG B CB  1 
ATOM   3813 C CG  . ARG B 2 62  ? 131.748 162.092 102.047 1.00 12.53 ? 62  ARG B CG  1 
ATOM   3814 C CD  . ARG B 2 62  ? 133.027 162.763 102.503 1.00 12.53 ? 62  ARG B CD  1 
ATOM   3815 N NE  . ARG B 2 62  ? 132.797 163.697 103.600 1.00 12.53 ? 62  ARG B NE  1 
ATOM   3816 C CZ  . ARG B 2 62  ? 133.661 164.634 103.973 1.00 12.53 ? 62  ARG B CZ  1 
ATOM   3817 N NH1 . ARG B 2 62  ? 133.371 165.442 104.984 1.00 12.53 ? 62  ARG B NH1 1 
ATOM   3818 N NH2 . ARG B 2 62  ? 134.816 164.764 103.336 1.00 12.53 ? 62  ARG B NH2 1 
ATOM   3819 N N   . ILE B 2 63  ? 132.259 158.692 100.319 1.00 10.64 ? 63  ILE B N   1 
ATOM   3820 C CA  . ILE B 2 63  ? 132.852 158.446 99.004  1.00 10.64 ? 63  ILE B CA  1 
ATOM   3821 C C   . ILE B 2 63  ? 131.818 157.843 98.061  1.00 10.64 ? 63  ILE B C   1 
ATOM   3822 O O   . ILE B 2 63  ? 131.664 158.280 96.913  1.00 10.64 ? 63  ILE B O   1 
ATOM   3823 C CB  . ILE B 2 63  ? 134.093 157.543 99.121  1.00 10.64 ? 63  ILE B CB  1 
ATOM   3824 C CG1 . ILE B 2 63  ? 135.174 158.206 99.968  1.00 10.64 ? 63  ILE B CG1 1 
ATOM   3825 C CG2 . ILE B 2 63  ? 134.650 157.244 97.745  1.00 10.64 ? 63  ILE B CG2 1 
ATOM   3826 C CD1 . ILE B 2 63  ? 136.504 157.488 99.917  1.00 10.64 ? 63  ILE B CD1 1 
ATOM   3827 N N   . ILE B 2 64  ? 131.086 156.834 98.538  1.00 10.65 ? 64  ILE B N   1 
ATOM   3828 C CA  . ILE B 2 64  ? 130.100 156.176 97.687  1.00 10.65 ? 64  ILE B CA  1 
ATOM   3829 C C   . ILE B 2 64  ? 128.972 157.136 97.327  1.00 10.65 ? 64  ILE B C   1 
ATOM   3830 O O   . ILE B 2 64  ? 128.489 157.144 96.188  1.00 10.65 ? 64  ILE B O   1 
ATOM   3831 C CB  . ILE B 2 64  ? 129.576 154.902 98.371  1.00 10.65 ? 64  ILE B CB  1 
ATOM   3832 C CG1 . ILE B 2 64  ? 130.722 153.920 98.600  1.00 10.65 ? 64  ILE B CG1 1 
ATOM   3833 C CG2 . ILE B 2 64  ? 128.502 154.250 97.528  1.00 10.65 ? 64  ILE B CG2 1 
ATOM   3834 C CD1 . ILE B 2 64  ? 130.312 152.675 99.334  1.00 10.65 ? 64  ILE B CD1 1 
ATOM   3835 N N   . THR B 2 65  ? 128.537 157.965 98.281  1.00 12.52 ? 65  THR B N   1 
ATOM   3836 C CA  . THR B 2 65  ? 127.469 158.920 98.010  1.00 12.52 ? 65  THR B CA  1 
ATOM   3837 C C   . THR B 2 65  ? 127.903 159.964 96.989  1.00 12.52 ? 65  THR B C   1 
ATOM   3838 O O   . THR B 2 65  ? 127.126 160.328 96.099  1.00 12.52 ? 65  THR B O   1 
ATOM   3839 C CB  . THR B 2 65  ? 127.030 159.592 99.310  1.00 12.52 ? 65  THR B CB  1 
ATOM   3840 O OG1 . THR B 2 65  ? 126.551 158.599 100.226 1.00 12.52 ? 65  THR B OG1 1 
ATOM   3841 C CG2 . THR B 2 65  ? 125.923 160.601 99.045  1.00 12.52 ? 65  THR B CG2 1 
ATOM   3842 N N   . GLU B 2 66  ? 129.137 160.461 97.100  1.00 12.38 ? 66  GLU B N   1 
ATOM   3843 C CA  . GLU B 2 66  ? 129.623 161.431 96.126  1.00 12.38 ? 66  GLU B CA  1 
ATOM   3844 C C   . GLU B 2 66  ? 129.759 160.802 94.745  1.00 12.38 ? 66  GLU B C   1 
ATOM   3845 O O   . GLU B 2 66  ? 129.440 161.438 93.732  1.00 12.38 ? 66  GLU B O   1 
ATOM   3846 C CB  . GLU B 2 66  ? 130.954 162.020 96.585  1.00 12.38 ? 66  GLU B CB  1 
ATOM   3847 C CG  . GLU B 2 66  ? 131.467 163.129 95.688  1.00 12.38 ? 66  GLU B CG  1 
ATOM   3848 C CD  . GLU B 2 66  ? 130.630 164.389 95.782  1.00 12.38 ? 66  GLU B CD  1 
ATOM   3849 O OE1 . GLU B 2 66  ? 130.673 165.205 94.837  1.00 12.38 ? 66  GLU B OE1 1 
ATOM   3850 O OE2 . GLU B 2 66  ? 129.934 164.568 96.802  1.00 12.38 ? 66  GLU B OE2 1 
ATOM   3851 N N   . GLY B 2 67  ? 130.227 159.552 94.683  1.00 12.65 ? 67  GLY B N   1 
ATOM   3852 C CA  . GLY B 2 67  ? 130.268 158.858 93.406  1.00 12.65 ? 67  GLY B CA  1 
ATOM   3853 C C   . GLY B 2 67  ? 128.891 158.696 92.792  1.00 12.65 ? 67  GLY B C   1 
ATOM   3854 O O   . GLY B 2 67  ? 128.709 158.897 91.589  1.00 12.65 ? 67  GLY B O   1 
ATOM   3855 N N   . ALA B 2 68  ? 127.899 158.339 93.612  1.00 13.41 ? 68  ALA B N   1 
ATOM   3856 C CA  . ALA B 2 68  ? 126.533 158.208 93.115  1.00 13.41 ? 68  ALA B CA  1 
ATOM   3857 C C   . ALA B 2 68  ? 125.993 159.543 92.620  1.00 13.41 ? 68  ALA B C   1 
ATOM   3858 O O   . ALA B 2 68  ? 125.327 159.607 91.580  1.00 13.41 ? 68  ALA B O   1 
ATOM   3859 C CB  . ALA B 2 68  ? 125.629 157.639 94.206  1.00 13.41 ? 68  ALA B CB  1 
ATOM   3860 N N   . SER B 2 69  ? 126.263 160.621 93.360  1.00 13.29 ? 69  SER B N   1 
ATOM   3861 C CA  . SER B 2 69  ? 125.781 161.938 92.957  1.00 13.29 ? 69  SER B CA  1 
ATOM   3862 C C   . SER B 2 69  ? 126.410 162.379 91.643  1.00 13.29 ? 69  SER B C   1 
ATOM   3863 O O   . SER B 2 69  ? 125.730 162.946 90.780  1.00 13.29 ? 69  SER B O   1 
ATOM   3864 C CB  . SER B 2 69  ? 126.064 162.959 94.058  1.00 13.29 ? 69  SER B CB  1 
ATOM   3865 O OG  . SER B 2 69  ? 125.369 162.633 95.248  1.00 13.29 ? 69  SER B OG  1 
ATOM   3866 N N   . ILE B 2 70  ? 127.710 162.128 91.470  1.00 13.00 ? 70  ILE B N   1 
ATOM   3867 C CA  . ILE B 2 70  ? 128.372 162.529 90.233  1.00 13.00 ? 70  ILE B CA  1 
ATOM   3868 C C   . ILE B 2 70  ? 128.038 161.596 89.074  1.00 13.00 ? 70  ILE B C   1 
ATOM   3869 O O   . ILE B 2 70  ? 128.175 161.994 87.911  1.00 13.00 ? 70  ILE B O   1 
ATOM   3870 C CB  . ILE B 2 70  ? 129.893 162.621 90.449  1.00 13.00 ? 70  ILE B CB  1 
ATOM   3871 C CG1 . ILE B 2 70  ? 130.556 163.397 89.309  1.00 13.00 ? 70  ILE B CG1 1 
ATOM   3872 C CG2 . ILE B 2 70  ? 130.505 161.242 90.583  1.00 13.00 ? 70  ILE B CG2 1 
ATOM   3873 C CD1 . ILE B 2 70  ? 131.967 163.843 89.617  1.00 13.00 ? 70  ILE B CD1 1 
ATOM   3874 N N   . LEU B 2 71  ? 127.586 160.372 89.354  1.00 14.34 ? 71  LEU B N   1 
ATOM   3875 C CA  . LEU B 2 71  ? 127.202 159.440 88.299  1.00 14.34 ? 71  LEU B CA  1 
ATOM   3876 C C   . LEU B 2 71  ? 125.748 159.580 87.875  1.00 14.34 ? 71  LEU B C   1 
ATOM   3877 O O   . LEU B 2 71  ? 125.404 159.211 86.746  1.00 14.34 ? 71  LEU B O   1 
ATOM   3878 C CB  . LEU B 2 71  ? 127.452 158.001 88.755  1.00 14.34 ? 71  LEU B CB  1 
ATOM   3879 C CG  . LEU B 2 71  ? 128.813 157.409 88.401  1.00 14.34 ? 71  LEU B CG  1 
ATOM   3880 C CD1 . LEU B 2 71  ? 128.839 155.921 88.701  1.00 14.34 ? 71  LEU B CD1 1 
ATOM   3881 C CD2 . LEU B 2 71  ? 129.122 157.671 86.939  1.00 14.34 ? 71  LEU B CD2 1 
ATOM   3882 N N   . ARG B 2 72  ? 124.884 160.093 88.753  1.00 13.06 ? 72  ARG B N   1 
ATOM   3883 C CA  . ARG B 2 72  ? 123.468 160.208 88.418  1.00 13.06 ? 72  ARG B CA  1 
ATOM   3884 C C   . ARG B 2 72  ? 123.250 161.161 87.249  1.00 13.06 ? 72  ARG B C   1 
ATOM   3885 O O   . ARG B 2 72  ? 122.400 160.913 86.387  1.00 13.06 ? 72  ARG B O   1 
ATOM   3886 C CB  . ARG B 2 72  ? 122.678 160.669 89.641  1.00 13.06 ? 72  ARG B CB  1 
ATOM   3887 C CG  . ARG B 2 72  ? 121.173 160.539 89.493  1.00 13.06 ? 72  ARG B CG  1 
ATOM   3888 C CD  . ARG B 2 72  ? 120.481 160.697 90.834  1.00 13.06 ? 72  ARG B CD  1 
ATOM   3889 N NE  . ARG B 2 72  ? 119.281 159.873 90.936  1.00 13.06 ? 72  ARG B NE  1 
ATOM   3890 C CZ  . ARG B 2 72  ? 119.072 158.977 91.894  1.00 13.06 ? 72  ARG B CZ  1 
ATOM   3891 N NH1 . ARG B 2 72  ? 119.984 158.788 92.838  1.00 13.06 ? 72  ARG B NH1 1 
ATOM   3892 N NH2 . ARG B 2 72  ? 117.951 158.270 91.911  1.00 13.06 ? 72  ARG B NH2 1 
ATOM   3893 N N   . GLN B 2 73  ? 124.007 162.259 87.205  1.00 13.77 ? 73  GLN B N   1 
ATOM   3894 C CA  . GLN B 2 73  ? 123.865 163.236 86.133  1.00 13.77 ? 73  GLN B CA  1 
ATOM   3895 C C   . GLN B 2 73  ? 124.321 162.706 84.780  1.00 13.77 ? 73  GLN B C   1 
ATOM   3896 O O   . GLN B 2 73  ? 124.029 163.337 83.760  1.00 13.77 ? 73  GLN B O   1 
ATOM   3897 C CB  . GLN B 2 73  ? 124.649 164.505 86.473  1.00 13.77 ? 73  GLN B CB  1 
ATOM   3898 C CG  . GLN B 2 73  ? 123.808 165.608 87.093  1.00 13.77 ? 73  GLN B CG  1 
ATOM   3899 C CD  . GLN B 2 73  ? 123.297 165.244 88.473  1.00 13.77 ? 73  GLN B CD  1 
ATOM   3900 O OE1 . GLN B 2 73  ? 124.059 164.810 89.335  1.00 13.77 ? 73  GLN B OE1 1 
ATOM   3901 N NE2 . GLN B 2 73  ? 121.999 165.423 88.689  1.00 13.77 ? 73  GLN B NE2 1 
ATOM   3902 N N   . GLU B 2 74  ? 125.026 161.579 84.746  1.00 13.66 ? 74  GLU B N   1 
ATOM   3903 C CA  . GLU B 2 74  ? 125.509 161.035 83.486  1.00 13.66 ? 74  GLU B CA  1 
ATOM   3904 C C   . GLU B 2 74  ? 124.347 160.562 82.620  1.00 13.66 ? 74  GLU B C   1 
ATOM   3905 O O   . GLU B 2 74  ? 123.338 160.054 83.115  1.00 13.66 ? 74  GLU B O   1 
ATOM   3906 C CB  . GLU B 2 74  ? 126.470 159.875 83.741  1.00 13.66 ? 74  GLU B CB  1 
ATOM   3907 C CG  . GLU B 2 74  ? 127.739 160.259 84.481  1.00 13.66 ? 74  GLU B CG  1 
ATOM   3908 C CD  . GLU B 2 74  ? 128.938 160.366 83.562  1.00 13.66 ? 74  GLU B CD  1 
ATOM   3909 O OE1 . GLU B 2 74  ? 128.756 160.765 82.394  1.00 13.66 ? 74  GLU B OE1 1 
ATOM   3910 O OE2 . GLU B 2 74  ? 130.060 160.044 84.005  1.00 13.66 ? 74  GLU B OE2 1 
ATOM   3911 N N   . LYS B 2 75  ? 124.499 160.738 81.311  1.00 15.28 ? 75  LYS B N   1 
ATOM   3912 C CA  . LYS B 2 75  ? 123.499 160.261 80.370  1.00 15.28 ? 75  LYS B CA  1 
ATOM   3913 C C   . LYS B 2 75  ? 123.522 158.739 80.287  1.00 15.28 ? 75  LYS B C   1 
ATOM   3914 O O   . LYS B 2 75  ? 124.507 158.084 80.639  1.00 15.28 ? 75  LYS B O   1 
ATOM   3915 C CB  . LYS B 2 75  ? 123.738 160.853 78.982  1.00 15.28 ? 75  LYS B CB  1 
ATOM   3916 C CG  . LYS B 2 75  ? 122.900 162.075 78.664  1.00 15.28 ? 75  LYS B CG  1 
ATOM   3917 C CD  . LYS B 2 75  ? 122.832 162.305 77.164  1.00 15.28 ? 75  LYS B CD  1 
ATOM   3918 C CE  . LYS B 2 75  ? 124.219 162.292 76.544  1.00 15.28 ? 75  LYS B CE  1 
ATOM   3919 N NZ  . LYS B 2 75  ? 124.179 162.556 75.080  1.00 15.28 ? 75  LYS B NZ  1 
ATOM   3920 N N   . ASN B 2 76  ? 122.409 158.174 79.813  1.00 18.64 ? 76  ASN B N   1 
ATOM   3921 C CA  . ASN B 2 76  ? 122.368 156.737 79.567  1.00 18.64 ? 76  ASN B CA  1 
ATOM   3922 C C   . ASN B 2 76  ? 123.369 156.332 78.496  1.00 18.64 ? 76  ASN B C   1 
ATOM   3923 O O   . ASN B 2 76  ? 124.038 155.302 78.628  1.00 18.64 ? 76  ASN B O   1 
ATOM   3924 C CB  . ASN B 2 76  ? 120.958 156.309 79.164  1.00 18.64 ? 76  ASN B CB  1 
ATOM   3925 C CG  . ASN B 2 76  ? 120.032 156.175 80.351  1.00 18.64 ? 76  ASN B CG  1 
ATOM   3926 O OD1 . ASN B 2 76  ? 120.474 156.174 81.500  1.00 18.64 ? 76  ASN B OD1 1 
ATOM   3927 N ND2 . ASN B 2 76  ? 118.737 156.061 80.082  1.00 18.64 ? 76  ASN B ND2 1 
ATOM   3928 N N   . LEU B 2 77  ? 123.493 157.130 77.440  1.00 17.18 ? 77  LEU B N   1 
ATOM   3929 C CA  . LEU B 2 77  ? 124.440 156.883 76.357  1.00 17.18 ? 77  LEU B CA  1 
ATOM   3930 C C   . LEU B 2 77  ? 125.544 157.931 76.456  1.00 17.18 ? 77  LEU B C   1 
ATOM   3931 O O   . LEU B 2 77  ? 125.325 159.107 76.146  1.00 17.18 ? 77  LEU B O   1 
ATOM   3932 C CB  . LEU B 2 77  ? 123.738 156.919 75.003  1.00 17.18 ? 77  LEU B CB  1 
ATOM   3933 C CG  . LEU B 2 77  ? 124.587 156.628 73.768  1.00 17.18 ? 77  LEU B CG  1 
ATOM   3934 C CD1 . LEU B 2 77  ? 123.828 155.742 72.804  1.00 17.18 ? 77  LEU B CD1 1 
ATOM   3935 C CD2 . LEU B 2 77  ? 124.973 157.930 73.091  1.00 17.18 ? 77  LEU B CD2 1 
ATOM   3936 N N   . LEU B 2 78  ? 126.725 157.502 76.892  1.00 16.87 ? 78  LEU B N   1 
ATOM   3937 C CA  . LEU B 2 78  ? 127.841 158.418 77.074  1.00 16.87 ? 78  LEU B CA  1 
ATOM   3938 C C   . LEU B 2 78  ? 128.446 158.807 75.730  1.00 16.87 ? 78  LEU B C   1 
ATOM   3939 O O   . LEU B 2 78  ? 128.340 158.079 74.740  1.00 16.87 ? 78  LEU B O   1 
ATOM   3940 C CB  . LEU B 2 78  ? 128.911 157.782 77.958  1.00 16.87 ? 78  LEU B CB  1 
ATOM   3941 C CG  . LEU B 2 78  ? 128.459 157.398 79.367  1.00 16.87 ? 78  LEU B CG  1 
ATOM   3942 C CD1 . LEU B 2 78  ? 129.574 156.692 80.115  1.00 16.87 ? 78  LEU B CD1 1 
ATOM   3943 C CD2 . LEU B 2 78  ? 127.987 158.619 80.129  1.00 16.87 ? 78  LEU B CD2 1 
ATOM   3944 N N   . ASP B 2 79  ? 129.081 159.973 75.704  1.00 13.85 ? 79  ASP B N   1 
ATOM   3945 C CA  . ASP B 2 79  ? 129.817 160.446 74.539  1.00 13.85 ? 79  ASP B CA  1 
ATOM   3946 C C   . ASP B 2 79  ? 131.296 160.490 74.893  1.00 13.85 ? 79  ASP B C   1 
ATOM   3947 O O   . ASP B 2 79  ? 131.700 161.233 75.794  1.00 13.85 ? 79  ASP B O   1 
ATOM   3948 C CB  . ASP B 2 79  ? 129.324 161.822 74.094  1.00 13.85 ? 79  ASP B CB  1 
ATOM   3949 C CG  . ASP B 2 79  ? 129.841 162.210 72.724  1.00 13.85 ? 79  ASP B CG  1 
ATOM   3950 O OD1 . ASP B 2 79  ? 130.481 163.276 72.609  1.00 13.85 ? 79  ASP B OD1 1 
ATOM   3951 O OD2 . ASP B 2 79  ? 129.611 161.445 71.764  1.00 13.85 ? 79  ASP B OD2 1 
ATOM   3952 N N   . ILE B 2 80  ? 132.097 159.700 74.185  1.00 13.61 ? 80  ILE B N   1 
ATOM   3953 C CA  . ILE B 2 80  ? 133.514 159.540 74.483  1.00 13.61 ? 80  ILE B CA  1 
ATOM   3954 C C   . ILE B 2 80  ? 134.310 159.781 73.208  1.00 13.61 ? 80  ILE B C   1 
ATOM   3955 O O   . ILE B 2 80  ? 133.935 159.302 72.132  1.00 13.61 ? 80  ILE B O   1 
ATOM   3956 C CB  . ILE B 2 80  ? 133.812 158.143 75.065  1.00 13.61 ? 80  ILE B CB  1 
ATOM   3957 C CG1 . ILE B 2 80  ? 133.087 157.954 76.396  1.00 13.61 ? 80  ILE B CG1 1 
ATOM   3958 C CG2 . ILE B 2 80  ? 135.287 157.960 75.286  1.00 13.61 ? 80  ILE B CG2 1 
ATOM   3959 C CD1 . ILE B 2 80  ? 133.119 156.533 76.899  1.00 13.61 ? 80  ILE B CD1 1 
ATOM   3960 N N   . ASP B 2 81  ? 135.407 160.523 73.328  1.00 15.35 ? 81  ASP B N   1 
ATOM   3961 C CA  . ASP B 2 81  ? 136.208 160.908 72.175  1.00 15.35 ? 81  ASP B CA  1 
ATOM   3962 C C   . ASP B 2 81  ? 137.090 159.740 71.730  1.00 15.35 ? 81  ASP B C   1 
ATOM   3963 O O   . ASP B 2 81  ? 136.985 158.619 72.235  1.00 15.35 ? 81  ASP B O   1 
ATOM   3964 C CB  . ASP B 2 81  ? 137.018 162.159 72.498  1.00 15.35 ? 81  ASP B CB  1 
ATOM   3965 C CG  . ASP B 2 81  ? 136.145 163.386 72.660  1.00 15.35 ? 81  ASP B CG  1 
ATOM   3966 O OD1 . ASP B 2 81  ? 135.063 163.431 72.036  1.00 15.35 ? 81  ASP B OD1 1 
ATOM   3967 O OD2 . ASP B 2 81  ? 136.536 164.305 73.409  1.00 15.35 ? 81  ASP B OD2 1 
ATOM   3968 N N   . ALA B 2 82  ? 137.986 160.000 70.764  1.00 17.04 ? 82  ALA B N   1 
ATOM   3969 C CA  . ALA B 2 82  ? 138.662 158.898 70.076  1.00 17.04 ? 82  ALA B CA  1 
ATOM   3970 C C   . ALA B 2 82  ? 139.733 158.226 70.929  1.00 17.04 ? 82  ALA B C   1 
ATOM   3971 O O   . ALA B 2 82  ? 139.607 157.021 71.210  1.00 17.04 ? 82  ALA B O   1 
ATOM   3972 C CB  . ALA B 2 82  ? 139.214 159.383 68.733  1.00 17.04 ? 82  ALA B CB  1 
ATOM   3973 N N   . PRO B 2 83  ? 140.806 158.918 71.374  1.00 16.63 ? 83  PRO B N   1 
ATOM   3974 C CA  . PRO B 2 83  ? 141.912 158.188 72.012  1.00 16.63 ? 83  PRO B CA  1 
ATOM   3975 C C   . PRO B 2 83  ? 141.533 157.674 73.388  1.00 16.63 ? 83  PRO B C   1 
ATOM   3976 O O   . PRO B 2 83  ? 141.454 158.451 74.344  1.00 16.63 ? 83  PRO B O   1 
ATOM   3977 C CB  . PRO B 2 83  ? 143.034 159.236 72.095  1.00 16.63 ? 83  PRO B CB  1 
ATOM   3978 C CG  . PRO B 2 83  ? 142.527 160.446 71.346  1.00 16.63 ? 83  PRO B CG  1 
ATOM   3979 C CD  . PRO B 2 83  ? 141.043 160.369 71.416  1.00 16.63 ? 83  PRO B CD  1 
ATOM   3980 N N   . VAL B 2 84  ? 141.301 156.365 73.506  1.00 14.89 ? 84  VAL B N   1 
ATOM   3981 C CA  . VAL B 2 84  ? 140.753 155.774 74.721  1.00 14.89 ? 84  VAL B CA  1 
ATOM   3982 C C   . VAL B 2 84  ? 141.433 154.441 75.001  1.00 14.89 ? 84  VAL B C   1 
ATOM   3983 O O   . VAL B 2 84  ? 142.147 153.883 74.166  1.00 14.89 ? 84  VAL B O   1 
ATOM   3984 C CB  . VAL B 2 84  ? 139.227 155.565 74.635  1.00 14.89 ? 84  VAL B CB  1 
ATOM   3985 C CG1 . VAL B 2 84  ? 138.516 156.892 74.537  1.00 14.89 ? 84  VAL B CG1 1 
ATOM   3986 C CG2 . VAL B 2 84  ? 138.882 154.680 73.451  1.00 14.89 ? 84  VAL B CG2 1 
ATOM   3987 N N   . THR B 2 85  ? 141.192 153.938 76.208  1.00 12.93 ? 85  THR B N   1 
ATOM   3988 C CA  . THR B 2 85  ? 141.621 152.611 76.625  1.00 12.93 ? 85  THR B CA  1 
ATOM   3989 C C   . THR B 2 85  ? 140.417 151.889 77.206  1.00 12.93 ? 85  THR B C   1 
ATOM   3990 O O   . THR B 2 85  ? 139.740 152.422 78.090  1.00 12.93 ? 85  THR B O   1 
ATOM   3991 C CB  . THR B 2 85  ? 142.752 152.692 77.650  1.00 12.93 ? 85  THR B CB  1 
ATOM   3992 O OG1 . THR B 2 85  ? 143.925 153.232 77.030  1.00 12.93 ? 85  THR B OG1 1 
ATOM   3993 C CG2 . THR B 2 85  ? 143.061 151.323 78.208  1.00 12.93 ? 85  THR B CG2 1 
ATOM   3994 N N   . VAL B 2 86  ? 140.155 150.683 76.713  1.00 11.24 ? 86  VAL B N   1 
ATOM   3995 C CA  . VAL B 2 86  ? 138.993 149.893 77.099  1.00 11.24 ? 86  VAL B CA  1 
ATOM   3996 C C   . VAL B 2 86  ? 139.468 148.691 77.899  1.00 11.24 ? 86  VAL B C   1 
ATOM   3997 O O   . VAL B 2 86  ? 140.422 148.005 77.502  1.00 11.24 ? 86  VAL B O   1 
ATOM   3998 C CB  . VAL B 2 86  ? 138.182 149.452 75.869  1.00 11.24 ? 86  VAL B CB  1 
ATOM   3999 C CG1 . VAL B 2 86  ? 137.011 148.589 76.292  1.00 11.24 ? 86  VAL B CG1 1 
ATOM   4000 C CG2 . VAL B 2 86  ? 137.704 150.665 75.093  1.00 11.24 ? 86  VAL B CG2 1 
ATOM   4001 N N   . CYS B 2 87  ? 138.807 148.441 79.028  1.00 8.34  ? 87  CYS B N   1 
ATOM   4002 C CA  . CYS B 2 87  ? 139.148 147.350 79.925  1.00 8.34  ? 87  CYS B CA  1 
ATOM   4003 C C   . CYS B 2 87  ? 137.894 146.564 80.275  1.00 8.34  ? 87  CYS B C   1 
ATOM   4004 O O   . CYS B 2 87  ? 136.787 147.106 80.289  1.00 8.34  ? 87  CYS B O   1 
ATOM   4005 C CB  . CYS B 2 87  ? 139.814 147.869 81.200  1.00 8.34  ? 87  CYS B CB  1 
ATOM   4006 S SG  . CYS B 2 87  ? 141.200 148.985 80.902  1.00 8.34  ? 87  CYS B SG  1 
ATOM   4007 N N   . GLY B 2 88  ? 138.079 145.280 80.564  1.00 7.61  ? 88  GLY B N   1 
ATOM   4008 C CA  . GLY B 2 88  ? 136.982 144.376 80.837  1.00 7.61  ? 88  GLY B CA  1 
ATOM   4009 C C   . GLY B 2 88  ? 136.580 144.352 82.296  1.00 7.61  ? 88  GLY B C   1 
ATOM   4010 O O   . GLY B 2 88  ? 136.943 145.225 83.087  1.00 7.61  ? 88  GLY B O   1 
ATOM   4011 N N   . ASP B 2 89  ? 135.809 143.329 82.653  1.00 6.91  ? 89  ASP B N   1 
ATOM   4012 C CA  . ASP B 2 89  ? 135.334 143.194 84.019  1.00 6.91  ? 89  ASP B CA  1 
ATOM   4013 C C   . ASP B 2 89  ? 136.480 142.816 84.950  1.00 6.91  ? 89  ASP B C   1 
ATOM   4014 O O   . ASP B 2 89  ? 137.555 142.397 84.518  1.00 6.91  ? 89  ASP B O   1 
ATOM   4015 C CB  . ASP B 2 89  ? 134.213 142.158 84.100  1.00 6.91  ? 89  ASP B CB  1 
ATOM   4016 C CG  . ASP B 2 89  ? 134.534 140.888 83.344  1.00 6.91  ? 89  ASP B CG  1 
ATOM   4017 O OD1 . ASP B 2 89  ? 135.128 140.984 82.252  1.00 6.91  ? 89  ASP B OD1 1 
ATOM   4018 O OD2 . ASP B 2 89  ? 134.174 139.796 83.832  1.00 6.91  ? 89  ASP B OD2 1 
ATOM   4019 N N   . ILE B 2 90  ? 136.237 142.979 86.250  1.00 4.75  ? 90  ILE B N   1 
ATOM   4020 C CA  . ILE B 2 90  ? 137.256 142.804 87.278  1.00 4.75  ? 90  ILE B CA  1 
ATOM   4021 C C   . ILE B 2 90  ? 136.894 141.680 88.241  1.00 4.75  ? 90  ILE B C   1 
ATOM   4022 O O   . ILE B 2 90  ? 137.693 140.771 88.481  1.00 4.75  ? 90  ILE B O   1 
ATOM   4023 C CB  . ILE B 2 90  ? 137.511 144.119 88.047  1.00 4.75  ? 90  ILE B CB  1 
ATOM   4024 C CG1 . ILE B 2 90  ? 138.113 145.175 87.122  1.00 4.75  ? 90  ILE B CG1 1 
ATOM   4025 C CG2 . ILE B 2 90  ? 138.425 143.875 89.223  1.00 4.75  ? 90  ILE B CG2 1 
ATOM   4026 C CD1 . ILE B 2 90  ? 137.092 146.061 86.460  1.00 4.75  ? 90  ILE B CD1 1 
ATOM   4027 N N   . HIS B 2 91  ? 135.692 141.734 88.812  1.00 5.70  ? 91  HIS B N   1 
ATOM   4028 C CA  . HIS B 2 91  ? 135.210 140.735 89.766  1.00 5.70  ? 91  HIS B CA  1 
ATOM   4029 C C   . HIS B 2 91  ? 136.066 140.705 91.032  1.00 5.70  ? 91  HIS B C   1 
ATOM   4030 O O   . HIS B 2 91  ? 136.500 139.650 91.494  1.00 5.70  ? 91  HIS B O   1 
ATOM   4031 C CB  . HIS B 2 91  ? 135.128 139.348 89.126  1.00 5.70  ? 91  HIS B CB  1 
ATOM   4032 C CG  . HIS B 2 91  ? 133.845 139.092 88.401  1.00 5.70  ? 91  HIS B CG  1 
ATOM   4033 N ND1 . HIS B 2 91  ? 133.791 138.862 87.044  1.00 5.70  ? 91  HIS B ND1 1 
ATOM   4034 C CD2 . HIS B 2 91  ? 132.567 139.033 88.844  1.00 5.70  ? 91  HIS B CD2 1 
ATOM   4035 C CE1 . HIS B 2 91  ? 132.536 138.668 86.682  1.00 5.70  ? 91  HIS B CE1 1 
ATOM   4036 N NE2 . HIS B 2 91  ? 131.773 138.767 87.756  1.00 5.70  ? 91  HIS B NE2 1 
ATOM   4037 N N   . GLY B 2 92  ? 136.307 141.884 91.595  1.00 5.44  ? 92  GLY B N   1 
ATOM   4038 C CA  . GLY B 2 92  ? 136.805 141.999 92.948  1.00 5.44  ? 92  GLY B CA  1 
ATOM   4039 C C   . GLY B 2 92  ? 138.298 141.862 93.136  1.00 5.44  ? 92  GLY B C   1 
ATOM   4040 O O   . GLY B 2 92  ? 138.765 141.950 94.277  1.00 5.44  ? 92  GLY B O   1 
ATOM   4041 N N   . GLN B 2 93  ? 139.068 141.660 92.073  1.00 5.73  ? 93  GLN B N   1 
ATOM   4042 C CA  . GLN B 2 93  ? 140.514 141.499 92.207  1.00 5.73  ? 93  GLN B CA  1 
ATOM   4043 C C   . GLN B 2 93  ? 141.157 142.877 92.303  1.00 5.73  ? 93  GLN B C   1 
ATOM   4044 O O   . GLN B 2 93  ? 141.408 143.536 91.292  1.00 5.73  ? 93  GLN B O   1 
ATOM   4045 C CB  . GLN B 2 93  ? 141.070 140.693 91.042  1.00 5.73  ? 93  GLN B CB  1 
ATOM   4046 C CG  . GLN B 2 93  ? 140.779 139.214 91.160  1.00 5.73  ? 93  GLN B CG  1 
ATOM   4047 C CD  . GLN B 2 93  ? 140.534 138.561 89.823  1.00 5.73  ? 93  GLN B CD  1 
ATOM   4048 O OE1 . GLN B 2 93  ? 140.647 139.200 88.779  1.00 5.73  ? 93  GLN B OE1 1 
ATOM   4049 N NE2 . GLN B 2 93  ? 140.187 137.280 89.846  1.00 5.73  ? 93  GLN B NE2 1 
ATOM   4050 N N   . PHE B 2 94  ? 141.425 143.312 93.535  1.00 3.85  ? 94  PHE B N   1 
ATOM   4051 C CA  . PHE B 2 94  ? 141.963 144.649 93.764  1.00 3.85  ? 94  PHE B CA  1 
ATOM   4052 C C   . PHE B 2 94  ? 143.374 144.787 93.208  1.00 3.85  ? 94  PHE B C   1 
ATOM   4053 O O   . PHE B 2 94  ? 143.671 145.727 92.462  1.00 3.85  ? 94  PHE B O   1 
ATOM   4054 C CB  . PHE B 2 94  ? 141.947 144.951 95.260  1.00 3.85  ? 94  PHE B CB  1 
ATOM   4055 C CG  . PHE B 2 94  ? 142.228 146.381 95.596  1.00 3.85  ? 94  PHE B CG  1 
ATOM   4056 C CD1 . PHE B 2 94  ? 143.524 146.830 95.743  1.00 3.85  ? 94  PHE B CD1 1 
ATOM   4057 C CD2 . PHE B 2 94  ? 141.193 147.274 95.780  1.00 3.85  ? 94  PHE B CD2 1 
ATOM   4058 C CE1 . PHE B 2 94  ? 143.779 148.143 96.058  1.00 3.85  ? 94  PHE B CE1 1 
ATOM   4059 C CE2 . PHE B 2 94  ? 141.445 148.588 96.094  1.00 3.85  ? 94  PHE B CE2 1 
ATOM   4060 C CZ  . PHE B 2 94  ? 142.737 149.021 96.237  1.00 3.85  ? 94  PHE B CZ  1 
ATOM   4061 N N   . PHE B 2 95  ? 144.261 143.859 93.565  1.00 5.86  ? 95  PHE B N   1 
ATOM   4062 C CA  . PHE B 2 95  ? 145.659 143.995 93.176  1.00 5.86  ? 95  PHE B CA  1 
ATOM   4063 C C   . PHE B 2 95  ? 145.831 143.859 91.670  1.00 5.86  ? 95  PHE B C   1 
ATOM   4064 O O   . PHE B 2 95  ? 146.687 144.530 91.078  1.00 5.86  ? 95  PHE B O   1 
ATOM   4065 C CB  . PHE B 2 95  ? 146.509 142.968 93.923  1.00 5.86  ? 95  PHE B CB  1 
ATOM   4066 C CG  . PHE B 2 95  ? 146.620 143.232 95.405  1.00 5.86  ? 95  PHE B CG  1 
ATOM   4067 C CD1 . PHE B 2 95  ? 145.530 143.059 96.241  1.00 5.86  ? 95  PHE B CD1 1 
ATOM   4068 C CD2 . PHE B 2 95  ? 147.816 143.646 95.959  1.00 5.86  ? 95  PHE B CD2 1 
ATOM   4069 C CE1 . PHE B 2 95  ? 145.629 143.300 97.594  1.00 5.86  ? 95  PHE B CE1 1 
ATOM   4070 C CE2 . PHE B 2 95  ? 147.918 143.884 97.314  1.00 5.86  ? 95  PHE B CE2 1 
ATOM   4071 C CZ  . PHE B 2 95  ? 146.823 143.710 98.130  1.00 5.86  ? 95  PHE B CZ  1 
ATOM   4072 N N   . ASP B 2 96  ? 145.019 143.016 91.032  1.00 6.65  ? 96  ASP B N   1 
ATOM   4073 C CA  . ASP B 2 96  ? 145.018 142.960 89.576  1.00 6.65  ? 96  ASP B CA  1 
ATOM   4074 C C   . ASP B 2 96  ? 144.546 144.280 88.979  1.00 6.65  ? 96  ASP B C   1 
ATOM   4075 O O   . ASP B 2 96  ? 145.048 144.710 87.937  1.00 6.65  ? 96  ASP B O   1 
ATOM   4076 C CB  . ASP B 2 96  ? 144.144 141.802 89.096  1.00 6.65  ? 96  ASP B CB  1 
ATOM   4077 C CG  . ASP B 2 96  ? 144.720 140.450 89.466  1.00 6.65  ? 96  ASP B CG  1 
ATOM   4078 O OD1 . ASP B 2 96  ? 145.854 140.152 89.041  1.00 6.65  ? 96  ASP B OD1 1 
ATOM   4079 O OD2 . ASP B 2 96  ? 144.042 139.685 90.183  1.00 6.65  ? 96  ASP B OD2 1 
ATOM   4080 N N   . LEU B 2 97  ? 143.590 144.945 89.633  1.00 7.24  ? 97  LEU B N   1 
ATOM   4081 C CA  . LEU B 2 97  ? 143.163 146.266 89.174  1.00 7.24  ? 97  LEU B CA  1 
ATOM   4082 C C   . LEU B 2 97  ? 144.299 147.277 89.264  1.00 7.24  ? 97  LEU B C   1 
ATOM   4083 O O   . LEU B 2 97  ? 144.476 148.106 88.364  1.00 7.24  ? 97  LEU B O   1 
ATOM   4084 C CB  . LEU B 2 97  ? 141.960 146.741 89.988  1.00 7.24  ? 97  LEU B CB  1 
ATOM   4085 C CG  . LEU B 2 97  ? 141.669 148.240 89.967  1.00 7.24  ? 97  LEU B CG  1 
ATOM   4086 C CD1 . LEU B 2 97  ? 141.266 148.688 88.579  1.00 7.24  ? 97  LEU B CD1 1 
ATOM   4087 C CD2 . LEU B 2 97  ? 140.585 148.572 90.965  1.00 7.24  ? 97  LEU B CD2 1 
ATOM   4088 N N   . MET B 2 98  ? 145.071 147.237 90.352  1.00 6.22  ? 98  MET B N   1 
ATOM   4089 C CA  . MET B 2 98  ? 146.203 148.150 90.477  1.00 6.22  ? 98  MET B CA  1 
ATOM   4090 C C   . MET B 2 98  ? 147.262 147.867 89.422  1.00 6.22  ? 98  MET B C   1 
ATOM   4091 O O   . MET B 2 98  ? 147.840 148.796 88.842  1.00 6.22  ? 98  MET B O   1 
ATOM   4092 C CB  . MET B 2 98  ? 146.796 148.067 91.880  1.00 6.22  ? 98  MET B CB  1 
ATOM   4093 C CG  . MET B 2 98  ? 145.829 148.550 92.915  1.00 6.22  ? 98  MET B CG  1 
ATOM   4094 S SD  . MET B 2 98  ? 145.531 150.285 92.580  1.00 6.22  ? 98  MET B SD  1 
ATOM   4095 C CE  . MET B 2 98  ? 144.209 150.616 93.722  1.00 6.22  ? 98  MET B CE  1 
ATOM   4096 N N   . LYS B 2 99  ? 147.531 146.588 89.156  1.00 10.24 ? 99  LYS B N   1 
ATOM   4097 C CA  . LYS B 2 99  ? 148.448 146.256 88.072  1.00 10.24 ? 99  LYS B CA  1 
ATOM   4098 C C   . LYS B 2 99  ? 147.906 146.728 86.730  1.00 10.24 ? 99  LYS B C   1 
ATOM   4099 O O   . LYS B 2 99  ? 148.677 147.144 85.861  1.00 10.24 ? 99  LYS B O   1 
ATOM   4100 C CB  . LYS B 2 99  ? 148.720 144.754 88.047  1.00 10.24 ? 99  LYS B CB  1 
ATOM   4101 C CG  . LYS B 2 99  ? 149.756 144.340 87.019  1.00 10.24 ? 99  LYS B CG  1 
ATOM   4102 C CD  . LYS B 2 99  ? 151.161 144.639 87.501  1.00 10.24 ? 99  LYS B CD  1 
ATOM   4103 C CE  . LYS B 2 99  ? 152.188 144.308 86.433  1.00 10.24 ? 99  LYS B CE  1 
ATOM   4104 N NZ  . LYS B 2 99  ? 152.156 142.868 86.061  1.00 10.24 ? 99  LYS B NZ  1 
ATOM   4105 N N   . LEU B 2 100 ? 146.584 146.682 86.546  1.00 8.90  ? 100 LEU B N   1 
ATOM   4106 C CA  . LEU B 2 100 ? 145.980 147.187 85.317  1.00 8.90  ? 100 LEU B CA  1 
ATOM   4107 C C   . LEU B 2 100 ? 146.191 148.686 85.173  1.00 8.90  ? 100 LEU B C   1 
ATOM   4108 O O   . LEU B 2 100 ? 146.512 149.176 84.084  1.00 8.90  ? 100 LEU B O   1 
ATOM   4109 C CB  . LEU B 2 100 ? 144.491 146.850 85.298  1.00 8.90  ? 100 LEU B CB  1 
ATOM   4110 C CG  . LEU B 2 100 ? 143.735 147.002 83.980  1.00 8.90  ? 100 LEU B CG  1 
ATOM   4111 C CD1 . LEU B 2 100 ? 142.744 145.862 83.818  1.00 8.90  ? 100 LEU B CD1 1 
ATOM   4112 C CD2 . LEU B 2 100 ? 143.023 148.342 83.929  1.00 8.90  ? 100 LEU B CD2 1 
ATOM   4113 N N   . PHE B 2 101 ? 146.001 149.431 86.263  1.00 9.79  ? 101 PHE B N   1 
ATOM   4114 C CA  . PHE B 2 101 ? 146.248 150.870 86.229  1.00 9.79  ? 101 PHE B CA  1 
ATOM   4115 C C   . PHE B 2 101 ? 147.708 151.161 85.912  1.00 9.79  ? 101 PHE B C   1 
ATOM   4116 O O   . PHE B 2 101 ? 148.015 152.090 85.157  1.00 9.79  ? 101 PHE B O   1 
ATOM   4117 C CB  . PHE B 2 101 ? 145.855 151.511 87.559  1.00 9.79  ? 101 PHE B CB  1 
ATOM   4118 C CG  . PHE B 2 101 ? 144.455 152.049 87.585  1.00 9.79  ? 101 PHE B CG  1 
ATOM   4119 C CD1 . PHE B 2 101 ? 144.046 152.996 86.673  1.00 9.79  ? 101 PHE B CD1 1 
ATOM   4120 C CD2 . PHE B 2 101 ? 143.551 151.614 88.533  1.00 9.79  ? 101 PHE B CD2 1 
ATOM   4121 C CE1 . PHE B 2 101 ? 142.761 153.492 86.704  1.00 9.79  ? 101 PHE B CE1 1 
ATOM   4122 C CE2 . PHE B 2 101 ? 142.267 152.109 88.566  1.00 9.79  ? 101 PHE B CE2 1 
ATOM   4123 C CZ  . PHE B 2 101 ? 141.872 153.046 87.651  1.00 9.79  ? 101 PHE B CZ  1 
ATOM   4124 N N   . GLU B 2 102 ? 148.623 150.379 86.487  1.00 13.07 ? 102 GLU B N   1 
ATOM   4125 C CA  . GLU B 2 102 ? 150.041 150.564 86.194  1.00 13.07 ? 102 GLU B CA  1 
ATOM   4126 C C   . GLU B 2 102 ? 150.355 150.263 84.732  1.00 13.07 ? 102 GLU B C   1 
ATOM   4127 O O   . GLU B 2 102 ? 151.148 150.973 84.104  1.00 13.07 ? 102 GLU B O   1 
ATOM   4128 C CB  . GLU B 2 102 ? 150.887 149.687 87.115  1.00 13.07 ? 102 GLU B CB  1 
ATOM   4129 C CG  . GLU B 2 102 ? 151.472 150.427 88.306  1.00 13.07 ? 102 GLU B CG  1 
ATOM   4130 C CD  . GLU B 2 102 ? 152.307 149.529 89.194  1.00 13.07 ? 102 GLU B CD  1 
ATOM   4131 O OE1 . GLU B 2 102 ? 152.108 149.559 90.427  1.00 13.07 ? 102 GLU B OE1 1 
ATOM   4132 O OE2 . GLU B 2 102 ? 153.161 148.792 88.659  1.00 13.07 ? 102 GLU B OE2 1 
ATOM   4133 N N   . VAL B 2 103 ? 149.749 149.211 84.178  1.00 12.70 ? 103 VAL B N   1 
ATOM   4134 C CA  . VAL B 2 103 ? 150.037 148.821 82.800  1.00 12.70 ? 103 VAL B CA  1 
ATOM   4135 C C   . VAL B 2 103 ? 149.473 149.839 81.818  1.00 12.70 ? 103 VAL B C   1 
ATOM   4136 O O   . VAL B 2 103 ? 150.146 150.235 80.858  1.00 12.70 ? 103 VAL B O   1 
ATOM   4137 C CB  . VAL B 2 103 ? 149.496 147.407 82.523  1.00 12.70 ? 103 VAL B CB  1 
ATOM   4138 C CG1 . VAL B 2 103 ? 149.497 147.121 81.034  1.00 12.70 ? 103 VAL B CG1 1 
ATOM   4139 C CG2 . VAL B 2 103 ? 150.333 146.371 83.254  1.00 12.70 ? 103 VAL B CG2 1 
ATOM   4140 N N   . GLY B 2 104 ? 148.242 150.286 82.040  1.00 13.30 ? 104 GLY B N   1 
ATOM   4141 C CA  . GLY B 2 104 ? 147.608 151.215 81.130  1.00 13.30 ? 104 GLY B CA  1 
ATOM   4142 C C   . GLY B 2 104 ? 148.027 152.658 81.272  1.00 13.30 ? 104 GLY B C   1 
ATOM   4143 O O   . GLY B 2 104 ? 147.546 153.509 80.520  1.00 13.30 ? 104 GLY B O   1 
ATOM   4144 N N   . GLY B 2 105 ? 148.912 152.964 82.215  1.00 13.39 ? 105 GLY B N   1 
ATOM   4145 C CA  . GLY B 2 105 ? 149.341 154.324 82.451  1.00 13.39 ? 105 GLY B CA  1 
ATOM   4146 C C   . GLY B 2 105 ? 148.484 155.033 83.483  1.00 13.39 ? 105 GLY B C   1 
ATOM   4147 O O   . GLY B 2 105 ? 147.423 154.563 83.900  1.00 13.39 ? 105 GLY B O   1 
ATOM   4148 N N   . SER B 2 106 ? 148.968 156.195 83.903  1.00 13.71 ? 106 SER B N   1 
ATOM   4149 C CA  . SER B 2 106 ? 148.261 156.970 84.909  1.00 13.71 ? 106 SER B CA  1 
ATOM   4150 C C   . SER B 2 106 ? 146.937 157.482 84.349  1.00 13.71 ? 106 SER B C   1 
ATOM   4151 O O   . SER B 2 106 ? 146.845 157.797 83.159  1.00 13.71 ? 106 SER B O   1 
ATOM   4152 C CB  . SER B 2 106 ? 149.115 158.146 85.377  1.00 13.71 ? 106 SER B CB  1 
ATOM   4153 O OG  . SER B 2 106 ? 148.349 159.061 86.141  1.00 13.71 ? 106 SER B OG  1 
ATOM   4154 N N   . PRO B 2 107 ? 145.894 157.574 85.176  1.00 12.73 ? 107 PRO B N   1 
ATOM   4155 C CA  . PRO B 2 107 ? 144.636 158.168 84.702  1.00 12.73 ? 107 PRO B CA  1 
ATOM   4156 C C   . PRO B 2 107 ? 144.774 159.625 84.301  1.00 12.73 ? 107 PRO B C   1 
ATOM   4157 O O   . PRO B 2 107 ? 143.905 160.141 83.588  1.00 12.73 ? 107 PRO B O   1 
ATOM   4158 C CB  . PRO B 2 107 ? 143.691 158.005 85.901  1.00 12.73 ? 107 PRO B CB  1 
ATOM   4159 C CG  . PRO B 2 107 ? 144.314 156.951 86.748  1.00 12.73 ? 107 PRO B CG  1 
ATOM   4160 C CD  . PRO B 2 107 ? 145.788 157.079 86.556  1.00 12.73 ? 107 PRO B CD  1 
ATOM   4161 N N   . ALA B 2 108 ? 145.827 160.311 84.752  1.00 14.08 ? 108 ALA B N   1 
ATOM   4162 C CA  . ALA B 2 108 ? 146.017 161.708 84.380  1.00 14.08 ? 108 ALA B CA  1 
ATOM   4163 C C   . ALA B 2 108 ? 146.271 161.861 82.885  1.00 14.08 ? 108 ALA B C   1 
ATOM   4164 O O   . ALA B 2 108 ? 145.756 162.793 82.255  1.00 14.08 ? 108 ALA B O   1 
ATOM   4165 C CB  . ALA B 2 108 ? 147.168 162.311 85.183  1.00 14.08 ? 108 ALA B CB  1 
ATOM   4166 N N   . ASN B 2 109 ? 147.061 160.963 82.299  1.00 16.92 ? 109 ASN B N   1 
ATOM   4167 C CA  . ASN B 2 109 ? 147.479 161.083 80.909  1.00 16.92 ? 109 ASN B CA  1 
ATOM   4168 C C   . ASN B 2 109 ? 146.658 160.235 79.946  1.00 16.92 ? 109 ASN B C   1 
ATOM   4169 O O   . ASN B 2 109 ? 146.947 160.238 78.746  1.00 16.92 ? 109 ASN B O   1 
ATOM   4170 C CB  . ASN B 2 109 ? 148.963 160.720 80.775  1.00 16.92 ? 109 ASN B CB  1 
ATOM   4171 C CG  . ASN B 2 109 ? 149.290 159.360 81.366  1.00 16.92 ? 109 ASN B CG  1 
ATOM   4172 O OD1 . ASN B 2 109 ? 148.669 158.353 81.024  1.00 16.92 ? 109 ASN B OD1 1 
ATOM   4173 N ND2 . ASN B 2 109 ? 150.271 159.326 82.260  1.00 16.92 ? 109 ASN B ND2 1 
ATOM   4174 N N   . THR B 2 110 ? 145.651 159.510 80.429  1.00 13.46 ? 110 THR B N   1 
ATOM   4175 C CA  . THR B 2 110 ? 144.842 158.677 79.551  1.00 13.46 ? 110 THR B CA  1 
ATOM   4176 C C   . THR B 2 110 ? 143.454 158.510 80.151  1.00 13.46 ? 110 THR B C   1 
ATOM   4177 O O   . THR B 2 110 ? 143.241 158.731 81.345  1.00 13.46 ? 110 THR B O   1 
ATOM   4178 C CB  . THR B 2 110 ? 145.488 157.307 79.313  1.00 13.46 ? 110 THR B CB  1 
ATOM   4179 O OG1 . THR B 2 110 ? 144.793 156.625 78.262  1.00 13.46 ? 110 THR B OG1 1 
ATOM   4180 C CG2 . THR B 2 110 ? 145.430 156.466 80.574  1.00 13.46 ? 110 THR B CG2 1 
ATOM   4181 N N   . ARG B 2 111 ? 142.509 158.114 79.304  1.00 13.82 ? 111 ARG B N   1 
ATOM   4182 C CA  . ARG B 2 111 ? 141.124 157.931 79.705  1.00 13.82 ? 111 ARG B CA  1 
ATOM   4183 C C   . ARG B 2 111 ? 140.702 156.482 79.491  1.00 13.82 ? 111 ARG B C   1 
ATOM   4184 O O   . ARG B 2 111 ? 141.154 155.815 78.556  1.00 13.82 ? 111 ARG B O   1 
ATOM   4185 C CB  . ARG B 2 111 ? 140.194 158.881 78.939  1.00 13.82 ? 111 ARG B CB  1 
ATOM   4186 C CG  . ARG B 2 111 ? 140.001 158.533 77.476  1.00 13.82 ? 111 ARG B CG  1 
ATOM   4187 C CD  . ARG B 2 111 ? 139.403 159.701 76.713  1.00 13.82 ? 111 ARG B CD  1 
ATOM   4188 N NE  . ARG B 2 111 ? 140.420 160.657 76.288  1.00 13.82 ? 111 ARG B NE  1 
ATOM   4189 C CZ  . ARG B 2 111 ? 140.156 161.781 75.632  1.00 13.82 ? 111 ARG B CZ  1 
ATOM   4190 N NH1 . ARG B 2 111 ? 138.905 162.092 75.327  1.00 13.82 ? 111 ARG B NH1 1 
ATOM   4191 N NH2 . ARG B 2 111 ? 141.141 162.595 75.282  1.00 13.82 ? 111 ARG B NH2 1 
ATOM   4192 N N   . TYR B 2 112 ? 139.833 156.001 80.376  1.00 11.09 ? 112 TYR B N   1 
ATOM   4193 C CA  . TYR B 2 112 ? 139.438 154.603 80.416  1.00 11.09 ? 112 TYR B CA  1 
ATOM   4194 C C   . TYR B 2 112 ? 137.943 154.460 80.171  1.00 11.09 ? 112 TYR B C   1 
ATOM   4195 O O   . TYR B 2 112 ? 137.179 155.425 80.256  1.00 11.09 ? 112 TYR B O   1 
ATOM   4196 C CB  . TYR B 2 112 ? 139.795 153.967 81.764  1.00 11.09 ? 112 TYR B CB  1 
ATOM   4197 C CG  . TYR B 2 112 ? 141.274 153.769 81.971  1.00 11.09 ? 112 TYR B CG  1 
ATOM   4198 C CD1 . TYR B 2 112 ? 142.145 153.754 80.897  1.00 11.09 ? 112 TYR B CD1 1 
ATOM   4199 C CD2 . TYR B 2 112 ? 141.799 153.599 83.240  1.00 11.09 ? 112 TYR B CD2 1 
ATOM   4200 C CE1 . TYR B 2 112 ? 143.498 153.572 81.079  1.00 11.09 ? 112 TYR B CE1 1 
ATOM   4201 C CE2 . TYR B 2 112 ? 143.150 153.418 83.430  1.00 11.09 ? 112 TYR B CE2 1 
ATOM   4202 C CZ  . TYR B 2 112 ? 143.994 153.406 82.348  1.00 11.09 ? 112 TYR B CZ  1 
ATOM   4203 O OH  . TYR B 2 112 ? 145.343 153.224 82.536  1.00 11.09 ? 112 TYR B OH  1 
ATOM   4204 N N   . LEU B 2 113 ? 137.534 153.229 79.863  1.00 10.05 ? 113 LEU B N   1 
ATOM   4205 C CA  . LEU B 2 113 ? 136.123 152.868 79.703  1.00 10.05 ? 113 LEU B CA  1 
ATOM   4206 C C   . LEU B 2 113 ? 135.930 151.505 80.366  1.00 10.05 ? 113 LEU B C   1 
ATOM   4207 O O   . LEU B 2 113 ? 136.095 150.464 79.728  1.00 10.05 ? 113 LEU B O   1 
ATOM   4208 C CB  . LEU B 2 113 ? 135.717 152.843 78.237  1.00 10.05 ? 113 LEU B CB  1 
ATOM   4209 C CG  . LEU B 2 113 ? 134.286 152.395 77.949  1.00 10.05 ? 113 LEU B CG  1 
ATOM   4210 C CD1 . LEU B 2 113 ? 133.314 153.208 78.772  1.00 10.05 ? 113 LEU B CD1 1 
ATOM   4211 C CD2 . LEU B 2 113 ? 133.974 152.520 76.472  1.00 10.05 ? 113 LEU B CD2 1 
ATOM   4212 N N   . PHE B 2 114 ? 135.589 151.519 81.648  1.00 9.03  ? 114 PHE B N   1 
ATOM   4213 C CA  . PHE B 2 114 ? 135.341 150.280 82.367  1.00 9.03  ? 114 PHE B CA  1 
ATOM   4214 C C   . PHE B 2 114 ? 133.941 149.773 82.053  1.00 9.03  ? 114 PHE B C   1 
ATOM   4215 O O   . PHE B 2 114 ? 132.970 150.532 82.092  1.00 9.03  ? 114 PHE B O   1 
ATOM   4216 C CB  . PHE B 2 114 ? 135.513 150.491 83.869  1.00 9.03  ? 114 PHE B CB  1 
ATOM   4217 C CG  . PHE B 2 114 ? 136.918 150.285 84.344  1.00 9.03  ? 114 PHE B CG  1 
ATOM   4218 C CD1 . PHE B 2 114 ? 137.971 150.926 83.723  1.00 9.03  ? 114 PHE B CD1 1 
ATOM   4219 C CD2 . PHE B 2 114 ? 137.188 149.441 85.404  1.00 9.03  ? 114 PHE B CD2 1 
ATOM   4220 C CE1 . PHE B 2 114 ? 139.266 150.733 84.151  1.00 9.03  ? 114 PHE B CE1 1 
ATOM   4221 C CE2 . PHE B 2 114 ? 138.482 149.246 85.837  1.00 9.03  ? 114 PHE B CE2 1 
ATOM   4222 C CZ  . PHE B 2 114 ? 139.521 149.892 85.210  1.00 9.03  ? 114 PHE B CZ  1 
ATOM   4223 N N   . LEU B 2 115 ? 133.839 148.481 81.744  1.00 7.67  ? 115 LEU B N   1 
ATOM   4224 C CA  . LEU B 2 115 ? 132.606 147.902 81.227  1.00 7.67  ? 115 LEU B CA  1 
ATOM   4225 C C   . LEU B 2 115 ? 131.913 146.967 82.204  1.00 7.67  ? 115 LEU B C   1 
ATOM   4226 O O   . LEU B 2 115 ? 130.735 147.160 82.513  1.00 7.67  ? 115 LEU B O   1 
ATOM   4227 C CB  . LEU B 2 115 ? 132.896 147.150 79.922  1.00 7.67  ? 115 LEU B CB  1 
ATOM   4228 C CG  . LEU B 2 115 ? 132.937 148.006 78.659  1.00 7.67  ? 115 LEU B CG  1 
ATOM   4229 C CD1 . LEU B 2 115 ? 133.307 147.163 77.455  1.00 7.67  ? 115 LEU B CD1 1 
ATOM   4230 C CD2 . LEU B 2 115 ? 131.602 148.686 78.447  1.00 7.67  ? 115 LEU B CD2 1 
ATOM   4231 N N   . GLY B 2 116 ? 132.613 145.960 82.707  1.00 6.27  ? 116 GLY B N   1 
ATOM   4232 C CA  . GLY B 2 116 ? 131.973 144.858 83.390  1.00 6.27  ? 116 GLY B CA  1 
ATOM   4233 C C   . GLY B 2 116 ? 131.656 145.135 84.846  1.00 6.27  ? 116 GLY B C   1 
ATOM   4234 O O   . GLY B 2 116 ? 131.762 146.253 85.350  1.00 6.27  ? 116 GLY B O   1 
ATOM   4235 N N   . ASP B 2 117 ? 131.241 144.071 85.525  1.00 7.44  ? 117 ASP B N   1 
ATOM   4236 C CA  . ASP B 2 117 ? 130.900 144.128 86.935  1.00 7.44  ? 117 ASP B CA  1 
ATOM   4237 C C   . ASP B 2 117 ? 132.153 144.223 87.797  1.00 7.44  ? 117 ASP B C   1 
ATOM   4238 O O   . ASP B 2 117 ? 133.254 143.866 87.379  1.00 7.44  ? 117 ASP B O   1 
ATOM   4239 C CB  . ASP B 2 117 ? 130.074 142.904 87.317  1.00 7.44  ? 117 ASP B CB  1 
ATOM   4240 C CG  . ASP B 2 117 ? 130.767 141.604 86.969  1.00 7.44  ? 117 ASP B CG  1 
ATOM   4241 O OD1 . ASP B 2 117 ? 131.851 141.658 86.357  1.00 7.44  ? 117 ASP B OD1 1 
ATOM   4242 O OD2 . ASP B 2 117 ? 130.227 140.527 87.299  1.00 7.44  ? 117 ASP B OD2 1 
ATOM   4243 N N   . TYR B 2 118 ? 131.970 144.711 89.025  1.00 10.41 ? 118 TYR B N   1 
ATOM   4244 C CA  . TYR B 2 118 ? 133.091 145.015 89.900  1.00 10.41 ? 118 TYR B CA  1 
ATOM   4245 C C   . TYR B 2 118 ? 133.078 144.301 91.243  1.00 10.41 ? 118 TYR B C   1 
ATOM   4246 O O   . TYR B 2 118 ? 134.055 144.432 91.984  1.00 10.41 ? 118 TYR B O   1 
ATOM   4247 C CB  . TYR B 2 118 ? 133.167 146.524 90.192  1.00 10.41 ? 118 TYR B CB  1 
ATOM   4248 C CG  . TYR B 2 118 ? 132.883 147.449 89.032  1.00 10.41 ? 118 TYR B CG  1 
ATOM   4249 C CD1 . TYR B 2 118 ? 133.841 147.698 88.065  1.00 10.41 ? 118 TYR B CD1 1 
ATOM   4250 C CD2 . TYR B 2 118 ? 131.666 148.099 88.926  1.00 10.41 ? 118 TYR B CD2 1 
ATOM   4251 C CE1 . TYR B 2 118 ? 133.585 148.551 87.014  1.00 10.41 ? 118 TYR B CE1 1 
ATOM   4252 C CE2 . TYR B 2 118 ? 131.402 148.951 87.879  1.00 10.41 ? 118 TYR B CE2 1 
ATOM   4253 C CZ  . TYR B 2 118 ? 132.364 149.174 86.927  1.00 10.41 ? 118 TYR B CZ  1 
ATOM   4254 O OH  . TYR B 2 118 ? 132.102 150.026 85.882  1.00 10.41 ? 118 TYR B OH  1 
ATOM   4255 N N   . VAL B 2 119 ? 132.024 143.574 91.600  1.00 5.95  ? 119 VAL B N   1 
ATOM   4256 C CA  . VAL B 2 119 ? 131.792 143.185 92.990  1.00 5.95  ? 119 VAL B CA  1 
ATOM   4257 C C   . VAL B 2 119 ? 131.916 141.673 93.210  1.00 5.95  ? 119 VAL B C   1 
ATOM   4258 O O   . VAL B 2 119 ? 132.757 141.223 93.987  1.00 5.95  ? 119 VAL B O   1 
ATOM   4259 C CB  . VAL B 2 119 ? 130.440 143.730 93.502  1.00 5.95  ? 119 VAL B CB  1 
ATOM   4260 C CG1 . VAL B 2 119 ? 130.485 145.235 93.527  1.00 5.95  ? 119 VAL B CG1 1 
ATOM   4261 C CG2 . VAL B 2 119 ? 129.303 143.309 92.603  1.00 5.95  ? 119 VAL B CG2 1 
ATOM   4262 N N   . ASP B 2 120 ? 131.088 140.878 92.543  1.00 5.35  ? 120 ASP B N   1 
ATOM   4263 C CA  . ASP B 2 120 ? 130.908 139.499 92.974  1.00 5.35  ? 120 ASP B CA  1 
ATOM   4264 C C   . ASP B 2 120 ? 132.127 138.638 92.648  1.00 5.35  ? 120 ASP B C   1 
ATOM   4265 O O   . ASP B 2 120 ? 132.961 138.979 91.807  1.00 5.35  ? 120 ASP B O   1 
ATOM   4266 C CB  . ASP B 2 120 ? 129.661 138.897 92.330  1.00 5.35  ? 120 ASP B CB  1 
ATOM   4267 C CG  . ASP B 2 120 ? 128.380 139.400 92.962  1.00 5.35  ? 120 ASP B CG  1 
ATOM   4268 O OD1 . ASP B 2 120 ? 128.277 139.370 94.205  1.00 5.35  ? 120 ASP B OD1 1 
ATOM   4269 O OD2 . ASP B 2 120 ? 127.474 139.820 92.214  1.00 5.35  ? 120 ASP B OD2 1 
ATOM   4270 N N   . ARG B 2 121 ? 132.220 137.506 93.353  1.00 4.47  ? 121 ARG B N   1 
ATOM   4271 C CA  . ARG B 2 121 ? 133.234 136.475 93.113  1.00 4.47  ? 121 ARG B CA  1 
ATOM   4272 C C   . ARG B 2 121 ? 134.647 136.999 93.369  1.00 4.47  ? 121 ARG B C   1 
ATOM   4273 O O   . ARG B 2 121 ? 135.542 136.882 92.531  1.00 4.47  ? 121 ARG B O   1 
ATOM   4274 C CB  . ARG B 2 121 ? 133.110 135.900 91.701  1.00 4.47  ? 121 ARG B CB  1 
ATOM   4275 C CG  . ARG B 2 121 ? 131.756 135.283 91.407  1.00 4.47  ? 121 ARG B CG  1 
ATOM   4276 C CD  . ARG B 2 121 ? 131.824 134.321 90.237  1.00 4.47  ? 121 ARG B CD  1 
ATOM   4277 N NE  . ARG B 2 121 ? 131.521 134.981 88.972  1.00 4.47  ? 121 ARG B NE  1 
ATOM   4278 C CZ  . ARG B 2 121 ? 130.355 134.886 88.342  1.00 4.47  ? 121 ARG B CZ  1 
ATOM   4279 N NH1 . ARG B 2 121 ? 129.379 134.159 88.862  1.00 4.47  ? 121 ARG B NH1 1 
ATOM   4280 N NH2 . ARG B 2 121 ? 130.164 135.518 87.193  1.00 4.47  ? 121 ARG B NH2 1 
ATOM   4281 N N   . GLY B 2 122 ? 134.843 137.571 94.553  1.00 2.03  ? 122 GLY B N   1 
ATOM   4282 C CA  . GLY B 2 122 ? 136.139 138.080 94.958  1.00 2.03  ? 122 GLY B CA  1 
ATOM   4283 C C   . GLY B 2 122 ? 136.100 138.602 96.376  1.00 2.03  ? 122 GLY B C   1 
ATOM   4284 O O   . GLY B 2 122 ? 135.048 139.043 96.844  1.00 2.03  ? 122 GLY B O   1 
ATOM   4285 N N   . TYR B 2 123 ? 137.228 138.562 97.077  1.00 2.23  ? 123 TYR B N   1 
ATOM   4286 C CA  . TYR B 2 123 ? 137.267 138.956 98.477  1.00 2.23  ? 123 TYR B CA  1 
ATOM   4287 C C   . TYR B 2 123 ? 137.709 140.400 98.685  1.00 2.23  ? 123 TYR B C   1 
ATOM   4288 O O   . TYR B 2 123 ? 137.794 140.847 99.832  1.00 2.23  ? 123 TYR B O   1 
ATOM   4289 C CB  . TYR B 2 123 ? 138.177 138.006 99.260  1.00 2.23  ? 123 TYR B CB  1 
ATOM   4290 C CG  . TYR B 2 123 ? 137.690 136.579 99.236  1.00 2.23  ? 123 TYR B CG  1 
ATOM   4291 C CD1 . TYR B 2 123 ? 136.464 136.240 99.779  1.00 2.23  ? 123 TYR B CD1 1 
ATOM   4292 C CD2 . TYR B 2 123 ? 138.450 135.573 98.662  1.00 2.23  ? 123 TYR B CD2 1 
ATOM   4293 C CE1 . TYR B 2 123 ? 136.004 134.944 99.754  1.00 2.23  ? 123 TYR B CE1 1 
ATOM   4294 C CE2 . TYR B 2 123 ? 137.998 134.270 98.633  1.00 2.23  ? 123 TYR B CE2 1 
ATOM   4295 C CZ  . TYR B 2 123 ? 136.774 133.965 99.181  1.00 2.23  ? 123 TYR B CZ  1 
ATOM   4296 O OH  . TYR B 2 123 ? 136.315 132.671 99.159  1.00 2.23  ? 123 TYR B OH  1 
ATOM   4297 N N   . PHE B 2 124 ? 137.974 141.141 97.614  1.00 3.52  ? 124 PHE B N   1 
ATOM   4298 C CA  . PHE B 2 124 ? 138.387 142.539 97.685  1.00 3.52  ? 124 PHE B CA  1 
ATOM   4299 C C   . PHE B 2 124 ? 137.475 143.400 96.821  1.00 3.52  ? 124 PHE B C   1 
ATOM   4300 O O   . PHE B 2 124 ? 137.921 144.206 96.004  1.00 3.52  ? 124 PHE B O   1 
ATOM   4301 C CB  . PHE B 2 124 ? 139.842 142.699 97.263  1.00 3.52  ? 124 PHE B CB  1 
ATOM   4302 C CG  . PHE B 2 124 ? 140.776 141.735 97.932  1.00 3.52  ? 124 PHE B CG  1 
ATOM   4303 C CD1 . PHE B 2 124 ? 140.773 141.586 99.305  1.00 3.52  ? 124 PHE B CD1 1 
ATOM   4304 C CD2 . PHE B 2 124 ? 141.665 140.983 97.186  1.00 3.52  ? 124 PHE B CD2 1 
ATOM   4305 C CE1 . PHE B 2 124 ? 141.633 140.701 99.921  1.00 3.52  ? 124 PHE B CE1 1 
ATOM   4306 C CE2 . PHE B 2 124 ? 142.526 140.099 97.796  1.00 3.52  ? 124 PHE B CE2 1 
ATOM   4307 C CZ  . PHE B 2 124 ? 142.509 139.958 99.166  1.00 3.52  ? 124 PHE B CZ  1 
ATOM   4308 N N   . SER B 2 125 ? 136.164 143.222 96.987  1.00 6.58  ? 125 SER B N   1 
ATOM   4309 C CA  . SER B 2 125 ? 135.198 143.940 96.165  1.00 6.58  ? 125 SER B CA  1 
ATOM   4310 C C   . SER B 2 125 ? 134.955 145.353 96.679  1.00 6.58  ? 125 SER B C   1 
ATOM   4311 O O   . SER B 2 125 ? 134.949 146.311 95.898  1.00 6.58  ? 125 SER B O   1 
ATOM   4312 C CB  . SER B 2 125 ? 133.884 143.170 96.119  1.00 6.58  ? 125 SER B CB  1 
ATOM   4313 O OG  . SER B 2 125 ? 133.395 142.967 97.428  1.00 6.58  ? 125 SER B OG  1 
ATOM   4314 N N   . ILE B 2 126 ? 134.733 145.499 97.988  1.00 4.82  ? 126 ILE B N   1 
ATOM   4315 C CA  . ILE B 2 126 ? 134.458 146.822 98.546  1.00 4.82  ? 126 ILE B CA  1 
ATOM   4316 C C   . ILE B 2 126 ? 135.659 147.739 98.355  1.00 4.82  ? 126 ILE B C   1 
ATOM   4317 O O   . ILE B 2 126 ? 135.508 148.928 98.056  1.00 4.82  ? 126 ILE B O   1 
ATOM   4318 C CB  . ILE B 2 126 ? 134.039 146.712 100.025 1.00 4.82  ? 126 ILE B CB  1 
ATOM   4319 C CG1 . ILE B 2 126 ? 133.555 148.063 100.541 1.00 4.82  ? 126 ILE B CG1 1 
ATOM   4320 C CG2 . ILE B 2 126 ? 135.168 146.184 100.888 1.00 4.82  ? 126 ILE B CG2 1 
ATOM   4321 C CD1 . ILE B 2 126 ? 132.335 148.577 99.829  1.00 4.82  ? 126 ILE B CD1 1 
ATOM   4322 N N   . GLU B 2 127 ? 136.869 147.195 98.489  1.00 2.74  ? 127 GLU B N   1 
ATOM   4323 C CA  . GLU B 2 127 ? 138.067 147.993 98.265  1.00 2.74  ? 127 GLU B CA  1 
ATOM   4324 C C   . GLU B 2 127 ? 138.163 148.445 96.813  1.00 2.74  ? 127 GLU B C   1 
ATOM   4325 O O   . GLU B 2 127 ? 138.486 149.609 96.534  1.00 2.74  ? 127 GLU B O   1 
ATOM   4326 C CB  . GLU B 2 127 ? 139.295 147.187 98.677  1.00 2.74  ? 127 GLU B CB  1 
ATOM   4327 C CG  . GLU B 2 127 ? 139.172 146.597 100.076 1.00 2.74  ? 127 GLU B CG  1 
ATOM   4328 C CD  . GLU B 2 127 ? 140.402 145.828 100.515 1.00 2.74  ? 127 GLU B CD  1 
ATOM   4329 O OE1 . GLU B 2 127 ? 141.346 145.689 99.711  1.00 2.74  ? 127 GLU B OE1 1 
ATOM   4330 O OE2 . GLU B 2 127 ? 140.423 145.362 101.672 1.00 2.74  ? 127 GLU B OE2 1 
ATOM   4331 N N   . CYS B 2 128 ? 137.865 147.544 95.875  1.00 2.78  ? 128 CYS B N   1 
ATOM   4332 C CA  . CYS B 2 128 ? 137.924 147.889 94.458  1.00 2.78  ? 128 CYS B CA  1 
ATOM   4333 C C   . CYS B 2 128 ? 136.914 148.972 94.111  1.00 2.78  ? 128 CYS B C   1 
ATOM   4334 O O   . CYS B 2 128 ? 137.237 149.939 93.409  1.00 2.78  ? 128 CYS B O   1 
ATOM   4335 C CB  . CYS B 2 128 ? 137.685 146.644 93.607  1.00 2.78  ? 128 CYS B CB  1 
ATOM   4336 S SG  . CYS B 2 128 ? 137.481 146.985 91.855  1.00 2.78  ? 128 CYS B SG  1 
ATOM   4337 N N   . VAL B 2 129 ? 135.681 148.831 94.601  1.00 2.83  ? 129 VAL B N   1 
ATOM   4338 C CA  . VAL B 2 129 ? 134.654 149.811 94.270  1.00 2.83  ? 129 VAL B CA  1 
ATOM   4339 C C   . VAL B 2 129 ? 134.964 151.156 94.924  1.00 2.83  ? 129 VAL B C   1 
ATOM   4340 O O   . VAL B 2 129 ? 134.767 152.214 94.312  1.00 2.83  ? 129 VAL B O   1 
ATOM   4341 C CB  . VAL B 2 129 ? 133.255 149.278 94.641  1.00 2.83  ? 129 VAL B CB  1 
ATOM   4342 C CG1 . VAL B 2 129 ? 133.056 149.224 96.132  1.00 2.83  ? 129 VAL B CG1 1 
ATOM   4343 C CG2 . VAL B 2 129 ? 132.183 150.126 93.994  1.00 2.83  ? 129 VAL B CG2 1 
ATOM   4344 N N   . LEU B 2 130 ? 135.502 151.143 96.151  1.00 3.65  ? 130 LEU B N   1 
ATOM   4345 C CA  . LEU B 2 130 ? 135.892 152.391 96.799  1.00 3.65  ? 130 LEU B CA  1 
ATOM   4346 C C   . LEU B 2 130 ? 136.966 153.113 95.999  1.00 3.65  ? 130 LEU B C   1 
ATOM   4347 O O   . LEU B 2 130 ? 136.859 154.317 95.749  1.00 3.65  ? 130 LEU B O   1 
ATOM   4348 C CB  . LEU B 2 130 ? 136.384 152.122 98.220  1.00 3.65  ? 130 LEU B CB  1 
ATOM   4349 C CG  . LEU B 2 130 ? 135.332 151.953 99.313  1.00 3.65  ? 130 LEU B CG  1 
ATOM   4350 C CD1 . LEU B 2 130 ? 135.970 152.076 100.683 1.00 3.65  ? 130 LEU B CD1 1 
ATOM   4351 C CD2 . LEU B 2 130 ? 134.225 152.969 99.142  1.00 3.65  ? 130 LEU B CD2 1 
ATOM   4352 N N   . TYR B 2 131 ? 138.016 152.395 95.591  1.00 4.66  ? 131 TYR B N   1 
ATOM   4353 C CA  . TYR B 2 131 ? 139.097 153.051 94.860  1.00 4.66  ? 131 TYR B CA  1 
ATOM   4354 C C   . TYR B 2 131 ? 138.612 153.581 93.516  1.00 4.66  ? 131 TYR B C   1 
ATOM   4355 O O   . TYR B 2 131 ? 138.920 154.720 93.138  1.00 4.66  ? 131 TYR B O   1 
ATOM   4356 C CB  . TYR B 2 131 ? 140.272 152.097 94.666  1.00 4.66  ? 131 TYR B CB  1 
ATOM   4357 C CG  . TYR B 2 131 ? 141.434 152.728 93.931  1.00 4.66  ? 131 TYR B CG  1 
ATOM   4358 C CD1 . TYR B 2 131 ? 142.384 153.472 94.611  1.00 4.66  ? 131 TYR B CD1 1 
ATOM   4359 C CD2 . TYR B 2 131 ? 141.582 152.578 92.563  1.00 4.66  ? 131 TYR B CD2 1 
ATOM   4360 C CE1 . TYR B 2 131 ? 143.447 154.050 93.950  1.00 4.66  ? 131 TYR B CE1 1 
ATOM   4361 C CE2 . TYR B 2 131 ? 142.642 153.152 91.893  1.00 4.66  ? 131 TYR B CE2 1 
ATOM   4362 C CZ  . TYR B 2 131 ? 143.572 153.886 92.592  1.00 4.66  ? 131 TYR B CZ  1 
ATOM   4363 O OH  . TYR B 2 131 ? 144.632 154.460 91.931  1.00 4.66  ? 131 TYR B OH  1 
ATOM   4364 N N   . LEU B 2 132 ? 137.849 152.767 92.777  1.00 4.38  ? 132 LEU B N   1 
ATOM   4365 C CA  . LEU B 2 132 ? 137.351 153.219 91.482  1.00 4.38  ? 132 LEU B CA  1 
ATOM   4366 C C   . LEU B 2 132 ? 136.492 154.462 91.630  1.00 4.38  ? 132 LEU B C   1 
ATOM   4367 O O   . LEU B 2 132 ? 136.631 155.416 90.858  1.00 4.38  ? 132 LEU B O   1 
ATOM   4368 C CB  . LEU B 2 132 ? 136.556 152.114 90.788  1.00 4.38  ? 132 LEU B CB  1 
ATOM   4369 C CG  . LEU B 2 132 ? 137.301 150.862 90.348  1.00 4.38  ? 132 LEU B CG  1 
ATOM   4370 C CD1 . LEU B 2 132 ? 136.323 149.845 89.819  1.00 4.38  ? 132 LEU B CD1 1 
ATOM   4371 C CD2 . LEU B 2 132 ? 138.302 151.229 89.277  1.00 4.38  ? 132 LEU B CD2 1 
ATOM   4372 N N   . TRP B 2 133 ? 135.616 154.490 92.631  1.00 8.31  ? 133 TRP B N   1 
ATOM   4373 C CA  . TRP B 2 133 ? 134.712 155.624 92.732  1.00 8.31  ? 133 TRP B CA  1 
ATOM   4374 C C   . TRP B 2 133 ? 135.398 156.859 93.300  1.00 8.31  ? 133 TRP B C   1 
ATOM   4375 O O   . TRP B 2 133 ? 135.028 157.981 92.943  1.00 8.31  ? 133 TRP B O   1 
ATOM   4376 C CB  . TRP B 2 133 ? 133.489 155.229 93.548  1.00 8.31  ? 133 TRP B CB  1 
ATOM   4377 C CG  . TRP B 2 133 ? 132.625 154.285 92.787  1.00 8.31  ? 133 TRP B CG  1 
ATOM   4378 C CD1 . TRP B 2 133 ? 133.005 153.474 91.757  1.00 8.31  ? 133 TRP B CD1 1 
ATOM   4379 C CD2 . TRP B 2 133 ? 131.229 154.072 92.967  1.00 8.31  ? 133 TRP B CD2 1 
ATOM   4380 N NE1 . TRP B 2 133 ? 131.933 152.758 91.296  1.00 8.31  ? 133 TRP B NE1 1 
ATOM   4381 C CE2 . TRP B 2 133 ? 130.828 153.108 92.023  1.00 8.31  ? 133 TRP B CE2 1 
ATOM   4382 C CE3 . TRP B 2 133 ? 130.278 154.597 93.839  1.00 8.31  ? 133 TRP B CE3 1 
ATOM   4383 C CZ2 . TRP B 2 133 ? 129.521 152.662 91.928  1.00 8.31  ? 133 TRP B CZ2 1 
ATOM   4384 C CZ3 . TRP B 2 133 ? 128.987 154.153 93.743  1.00 8.31  ? 133 TRP B CZ3 1 
ATOM   4385 C CH2 . TRP B 2 133 ? 128.615 153.195 92.797  1.00 8.31  ? 133 TRP B CH2 1 
ATOM   4386 N N   . ALA B 2 134 ? 136.409 156.688 94.153  1.00 7.68  ? 134 ALA B N   1 
ATOM   4387 C CA  . ALA B 2 134 ? 137.200 157.838 94.574  1.00 7.68  ? 134 ALA B CA  1 
ATOM   4388 C C   . ALA B 2 134 ? 137.934 158.455 93.392  1.00 7.68  ? 134 ALA B C   1 
ATOM   4389 O O   . ALA B 2 134 ? 137.958 159.683 93.237  1.00 7.68  ? 134 ALA B O   1 
ATOM   4390 C CB  . ALA B 2 134 ? 138.186 157.433 95.668  1.00 7.68  ? 134 ALA B CB  1 
ATOM   4391 N N   . LEU B 2 135 ? 138.529 157.620 92.536  1.00 7.56  ? 135 LEU B N   1 
ATOM   4392 C CA  . LEU B 2 135 ? 139.199 158.171 91.364  1.00 7.56  ? 135 LEU B CA  1 
ATOM   4393 C C   . LEU B 2 135 ? 138.192 158.759 90.382  1.00 7.56  ? 135 LEU B C   1 
ATOM   4394 O O   . LEU B 2 135 ? 138.528 159.675 89.624  1.00 7.56  ? 135 LEU B O   1 
ATOM   4395 C CB  . LEU B 2 135 ? 140.063 157.102 90.699  1.00 7.56  ? 135 LEU B CB  1 
ATOM   4396 C CG  . LEU B 2 135 ? 141.145 157.598 89.736  1.00 7.56  ? 135 LEU B CG  1 
ATOM   4397 C CD1 . LEU B 2 135 ? 142.345 156.680 89.797  1.00 7.56  ? 135 LEU B CD1 1 
ATOM   4398 C CD2 . LEU B 2 135 ? 140.632 157.682 88.314  1.00 7.56  ? 135 LEU B CD2 1 
ATOM   4399 N N   . LYS B 2 136 ? 136.959 158.249 90.381  1.00 9.31  ? 136 LYS B N   1 
ATOM   4400 C CA  . LYS B 2 136 ? 135.896 158.882 89.608  1.00 9.31  ? 136 LYS B CA  1 
ATOM   4401 C C   . LYS B 2 136 ? 135.572 160.268 90.152  1.00 9.31  ? 136 LYS B C   1 
ATOM   4402 O O   . LYS B 2 136 ? 135.346 161.209 89.383  1.00 9.31  ? 136 LYS B O   1 
ATOM   4403 C CB  . LYS B 2 136 ? 134.648 157.999 89.614  1.00 9.31  ? 136 LYS B CB  1 
ATOM   4404 C CG  . LYS B 2 136 ? 133.459 158.584 88.876  1.00 9.31  ? 136 LYS B CG  1 
ATOM   4405 C CD  . LYS B 2 136 ? 133.778 158.826 87.415  1.00 9.31  ? 136 LYS B CD  1 
ATOM   4406 C CE  . LYS B 2 136 ? 132.511 158.938 86.591  1.00 9.31  ? 136 LYS B CE  1 
ATOM   4407 N NZ  . LYS B 2 136 ? 132.763 159.544 85.259  1.00 9.31  ? 136 LYS B NZ  1 
ATOM   4408 N N   . ILE B 2 137 ? 135.531 160.407 91.478  1.00 10.53 ? 137 ILE B N   1 
ATOM   4409 C CA  . ILE B 2 137 ? 135.266 161.708 92.089  1.00 10.53 ? 137 ILE B CA  1 
ATOM   4410 C C   . ILE B 2 137 ? 136.367 162.696 91.726  1.00 10.53 ? 137 ILE B C   1 
ATOM   4411 O O   . ILE B 2 137 ? 136.101 163.847 91.362  1.00 10.53 ? 137 ILE B O   1 
ATOM   4412 C CB  . ILE B 2 137 ? 135.121 161.567 93.615  1.00 10.53 ? 137 ILE B CB  1 
ATOM   4413 C CG1 . ILE B 2 137 ? 133.847 160.799 93.966  1.00 10.53 ? 137 ILE B CG1 1 
ATOM   4414 C CG2 . ILE B 2 137 ? 135.124 162.935 94.278  1.00 10.53 ? 137 ILE B CG2 1 
ATOM   4415 C CD1 . ILE B 2 137 ? 133.865 160.197 95.352  1.00 10.53 ? 137 ILE B CD1 1 
ATOM   4416 N N   . LEU B 2 138 ? 137.624 162.258 91.820  1.00 11.58 ? 138 LEU B N   1 
ATOM   4417 C CA  . LEU B 2 138 ? 138.733 163.144 91.482  1.00 11.58 ? 138 LEU B CA  1 
ATOM   4418 C C   . LEU B 2 138 ? 138.772 163.428 89.984  1.00 11.58 ? 138 LEU B C   1 
ATOM   4419 O O   . LEU B 2 138 ? 138.921 164.582 89.567  1.00 11.58 ? 138 LEU B O   1 
ATOM   4420 C CB  . LEU B 2 138 ? 140.053 162.538 91.962  1.00 11.58 ? 138 LEU B CB  1 
ATOM   4421 C CG  . LEU B 2 138 ? 141.319 163.395 91.866  1.00 11.58 ? 138 LEU B CG  1 
ATOM   4422 C CD1 . LEU B 2 138 ? 142.314 162.955 92.921  1.00 11.58 ? 138 LEU B CD1 1 
ATOM   4423 C CD2 . LEU B 2 138 ? 141.966 163.330 90.494  1.00 11.58 ? 138 LEU B CD2 1 
ATOM   4424 N N   . TYR B 2 139 ? 138.645 162.388 89.158  1.00 12.28 ? 139 TYR B N   1 
ATOM   4425 C CA  . TYR B 2 139 ? 138.627 162.543 87.705  1.00 12.28 ? 139 TYR B CA  1 
ATOM   4426 C C   . TYR B 2 139 ? 137.211 162.314 87.200  1.00 12.28 ? 139 TYR B C   1 
ATOM   4427 O O   . TYR B 2 139 ? 136.776 161.159 87.082  1.00 12.28 ? 139 TYR B O   1 
ATOM   4428 C CB  . TYR B 2 139 ? 139.589 161.558 87.034  1.00 12.28 ? 139 TYR B CB  1 
ATOM   4429 C CG  . TYR B 2 139 ? 141.057 161.846 87.230  1.00 12.28 ? 139 TYR B CG  1 
ATOM   4430 C CD1 . TYR B 2 139 ? 141.869 160.952 87.912  1.00 12.28 ? 139 TYR B CD1 1 
ATOM   4431 C CD2 . TYR B 2 139 ? 141.635 162.999 86.721  1.00 12.28 ? 139 TYR B CD2 1 
ATOM   4432 C CE1 . TYR B 2 139 ? 143.215 161.199 88.088  1.00 12.28 ? 139 TYR B CE1 1 
ATOM   4433 C CE2 . TYR B 2 139 ? 142.981 163.256 86.895  1.00 12.28 ? 139 TYR B CE2 1 
ATOM   4434 C CZ  . TYR B 2 139 ? 143.765 162.352 87.580  1.00 12.28 ? 139 TYR B CZ  1 
ATOM   4435 O OH  . TYR B 2 139 ? 145.106 162.598 87.759  1.00 12.28 ? 139 TYR B OH  1 
ATOM   4436 N N   . PRO B 2 140 ? 136.455 163.363 86.870  1.00 13.59 ? 140 PRO B N   1 
ATOM   4437 C CA  . PRO B 2 140 ? 135.075 163.170 86.416  1.00 13.59 ? 140 PRO B CA  1 
ATOM   4438 C C   . PRO B 2 140 ? 134.896 163.031 84.912  1.00 13.59 ? 140 PRO B C   1 
ATOM   4439 O O   . PRO B 2 140 ? 133.828 162.572 84.486  1.00 13.59 ? 140 PRO B O   1 
ATOM   4440 C CB  . PRO B 2 140 ? 134.379 164.439 86.925  1.00 13.59 ? 140 PRO B CB  1 
ATOM   4441 C CG  . PRO B 2 140 ? 135.467 165.483 86.973  1.00 13.59 ? 140 PRO B CG  1 
ATOM   4442 C CD  . PRO B 2 140 ? 136.809 164.788 86.962  1.00 13.59 ? 140 PRO B CD  1 
ATOM   4443 N N   . LYS B 2 141 ? 135.892 163.393 84.102  1.00 16.03 ? 141 LYS B N   1 
ATOM   4444 C CA  . LYS B 2 141 ? 135.761 163.353 82.652  1.00 16.03 ? 141 LYS B CA  1 
ATOM   4445 C C   . LYS B 2 141 ? 136.709 162.387 81.958  1.00 16.03 ? 141 LYS B C   1 
ATOM   4446 O O   . LYS B 2 141 ? 136.510 162.112 80.770  1.00 16.03 ? 141 LYS B O   1 
ATOM   4447 C CB  . LYS B 2 141 ? 135.978 164.752 82.051  1.00 16.03 ? 141 LYS B CB  1 
ATOM   4448 C CG  . LYS B 2 141 ? 134.989 165.831 82.492  1.00 16.03 ? 141 LYS B CG  1 
ATOM   4449 C CD  . LYS B 2 141 ? 133.597 165.648 81.888  1.00 16.03 ? 141 LYS B CD  1 
ATOM   4450 C CE  . LYS B 2 141 ? 132.648 164.890 82.805  1.00 16.03 ? 141 LYS B CE  1 
ATOM   4451 N NZ  . LYS B 2 141 ? 131.270 164.815 82.246  1.00 16.03 ? 141 LYS B NZ  1 
ATOM   4452 N N   . THR B 2 142 ? 137.725 161.869 82.646  1.00 13.12 ? 142 THR B N   1 
ATOM   4453 C CA  . THR B 2 142 ? 138.716 160.999 82.025  1.00 13.12 ? 142 THR B CA  1 
ATOM   4454 C C   . THR B 2 142 ? 138.531 159.536 82.410  1.00 13.12 ? 142 THR B C   1 
ATOM   4455 O O   . THR B 2 142 ? 139.462 158.740 82.264  1.00 13.12 ? 142 THR B O   1 
ATOM   4456 C CB  . THR B 2 142 ? 140.129 161.459 82.382  1.00 13.12 ? 142 THR B CB  1 
ATOM   4457 O OG1 . THR B 2 142 ? 140.213 161.709 83.790  1.00 13.12 ? 142 THR B OG1 1 
ATOM   4458 C CG2 . THR B 2 142 ? 140.483 162.731 81.624  1.00 13.12 ? 142 THR B CG2 1 
ATOM   4459 N N   . LEU B 2 143 ? 137.352 159.166 82.904  1.00 10.11 ? 143 LEU B N   1 
ATOM   4460 C CA  . LEU B 2 143 ? 137.088 157.784 83.283  1.00 10.11 ? 143 LEU B CA  1 
ATOM   4461 C C   . LEU B 2 143 ? 135.584 157.582 83.355  1.00 10.11 ? 143 LEU B C   1 
ATOM   4462 O O   . LEU B 2 143 ? 134.887 158.354 84.020  1.00 10.11 ? 143 LEU B O   1 
ATOM   4463 C CB  . LEU B 2 143 ? 137.754 157.444 84.620  1.00 10.11 ? 143 LEU B CB  1 
ATOM   4464 C CG  . LEU B 2 143 ? 137.691 155.996 85.094  1.00 10.11 ? 143 LEU B CG  1 
ATOM   4465 C CD1 . LEU B 2 143 ? 138.980 155.621 85.781  1.00 10.11 ? 143 LEU B CD1 1 
ATOM   4466 C CD2 . LEU B 2 143 ? 136.539 155.820 86.053  1.00 10.11 ? 143 LEU B CD2 1 
ATOM   4467 N N   . PHE B 2 144 ? 135.091 156.550 82.675  1.00 10.65 ? 144 PHE B N   1 
ATOM   4468 C CA  . PHE B 2 144 ? 133.663 156.281 82.584  1.00 10.65 ? 144 PHE B CA  1 
ATOM   4469 C C   . PHE B 2 144 ? 133.381 154.856 83.029  1.00 10.65 ? 144 PHE B C   1 
ATOM   4470 O O   . PHE B 2 144 ? 133.970 153.910 82.498  1.00 10.65 ? 144 PHE B O   1 
ATOM   4471 C CB  . PHE B 2 144 ? 133.161 156.497 81.157  1.00 10.65 ? 144 PHE B CB  1 
ATOM   4472 C CG  . PHE B 2 144 ? 133.527 157.834 80.587  1.00 10.65 ? 144 PHE B CG  1 
ATOM   4473 C CD1 . PHE B 2 144 ? 134.626 157.970 79.759  1.00 10.65 ? 144 PHE B CD1 1 
ATOM   4474 C CD2 . PHE B 2 144 ? 132.772 158.956 80.882  1.00 10.65 ? 144 PHE B CD2 1 
ATOM   4475 C CE1 . PHE B 2 144 ? 134.966 159.199 79.234  1.00 10.65 ? 144 PHE B CE1 1 
ATOM   4476 C CE2 . PHE B 2 144 ? 133.106 160.188 80.359  1.00 10.65 ? 144 PHE B CE2 1 
ATOM   4477 C CZ  . PHE B 2 144 ? 134.205 160.309 79.534  1.00 10.65 ? 144 PHE B CZ  1 
ATOM   4478 N N   . LEU B 2 145 ? 132.479 154.707 83.992  1.00 8.90  ? 145 LEU B N   1 
ATOM   4479 C CA  . LEU B 2 145 ? 132.074 153.404 84.495  1.00 8.90  ? 145 LEU B CA  1 
ATOM   4480 C C   . LEU B 2 145 ? 130.774 152.969 83.834  1.00 8.90  ? 145 LEU B C   1 
ATOM   4481 O O   . LEU B 2 145 ? 129.921 153.794 83.501  1.00 8.90  ? 145 LEU B O   1 
ATOM   4482 C CB  . LEU B 2 145 ? 131.892 153.435 86.012  1.00 8.90  ? 145 LEU B CB  1 
ATOM   4483 C CG  . LEU B 2 145 ? 133.047 153.977 86.845  1.00 8.90  ? 145 LEU B CG  1 
ATOM   4484 C CD1 . LEU B 2 145 ? 132.619 154.109 88.291  1.00 8.90  ? 145 LEU B CD1 1 
ATOM   4485 C CD2 . LEU B 2 145 ? 134.245 153.064 86.724  1.00 8.90  ? 145 LEU B CD2 1 
ATOM   4486 N N   . LEU B 2 146 ? 130.628 151.659 83.648  1.00 8.79  ? 146 LEU B N   1 
ATOM   4487 C CA  . LEU B 2 146 ? 129.444 151.085 83.027  1.00 8.79  ? 146 LEU B CA  1 
ATOM   4488 C C   . LEU B 2 146 ? 128.856 150.015 83.933  1.00 8.79  ? 146 LEU B C   1 
ATOM   4489 O O   . LEU B 2 146 ? 129.577 149.348 84.678  1.00 8.79  ? 146 LEU B O   1 
ATOM   4490 C CB  . LEU B 2 146 ? 129.757 150.480 81.656  1.00 8.79  ? 146 LEU B CB  1 
ATOM   4491 C CG  . LEU B 2 146 ? 129.498 151.352 80.429  1.00 8.79  ? 146 LEU B CG  1 
ATOM   4492 C CD1 . LEU B 2 146 ? 128.016 151.591 80.260  1.00 8.79  ? 146 LEU B CD1 1 
ATOM   4493 C CD2 . LEU B 2 146 ? 130.232 152.666 80.549  1.00 8.79  ? 146 LEU B CD2 1 
ATOM   4494 N N   . ARG B 2 147 ? 127.537 149.863 83.864  1.00 9.88  ? 147 ARG B N   1 
ATOM   4495 C CA  . ARG B 2 147 ? 126.855 148.853 84.659  1.00 9.88  ? 147 ARG B CA  1 
ATOM   4496 C C   . ARG B 2 147 ? 127.128 147.458 84.113  1.00 9.88  ? 147 ARG B C   1 
ATOM   4497 O O   . ARG B 2 147 ? 127.246 147.251 82.903  1.00 9.88  ? 147 ARG B O   1 
ATOM   4498 C CB  . ARG B 2 147 ? 125.349 149.113 84.683  1.00 9.88  ? 147 ARG B CB  1 
ATOM   4499 C CG  . ARG B 2 147 ? 124.585 148.147 85.566  1.00 9.88  ? 147 ARG B CG  1 
ATOM   4500 C CD  . ARG B 2 147 ? 123.334 148.766 86.145  1.00 9.88  ? 147 ARG B CD  1 
ATOM   4501 N NE  . ARG B 2 147 ? 122.968 148.119 87.399  1.00 9.88  ? 147 ARG B NE  1 
ATOM   4502 C CZ  . ARG B 2 147 ? 121.827 148.328 88.042  1.00 9.88  ? 147 ARG B CZ  1 
ATOM   4503 N NH1 . ARG B 2 147 ? 120.930 149.169 87.549  1.00 9.88  ? 147 ARG B NH1 1 
ATOM   4504 N NH2 . ARG B 2 147 ? 121.584 147.694 89.179  1.00 9.88  ? 147 ARG B NH2 1 
ATOM   4505 N N   . GLY B 2 148 ? 127.229 146.494 85.022  1.00 7.41  ? 148 GLY B N   1 
ATOM   4506 C CA  . GLY B 2 148 ? 127.442 145.117 84.628  1.00 7.41  ? 148 GLY B CA  1 
ATOM   4507 C C   . GLY B 2 148 ? 126.249 144.228 84.905  1.00 7.41  ? 148 GLY B C   1 
ATOM   4508 O O   . GLY B 2 148 ? 125.136 144.719 85.113  1.00 7.41  ? 148 GLY B O   1 
ATOM   4509 N N   . ASN B 2 149 ? 126.466 142.915 84.901  1.00 6.86  ? 149 ASN B N   1 
ATOM   4510 C CA  . ASN B 2 149 ? 125.409 141.956 85.184  1.00 6.86  ? 149 ASN B CA  1 
ATOM   4511 C C   . ASN B 2 149 ? 125.341 141.550 86.649  1.00 6.86  ? 149 ASN B C   1 
ATOM   4512 O O   . ASN B 2 149 ? 124.431 140.804 87.022  1.00 6.86  ? 149 ASN B O   1 
ATOM   4513 C CB  . ASN B 2 149 ? 125.588 140.707 84.314  1.00 6.86  ? 149 ASN B CB  1 
ATOM   4514 C CG  . ASN B 2 149 ? 127.017 140.195 84.311  1.00 6.86  ? 149 ASN B CG  1 
ATOM   4515 O OD1 . ASN B 2 149 ? 127.892 140.760 84.963  1.00 6.86  ? 149 ASN B OD1 1 
ATOM   4516 N ND2 . ASN B 2 149 ? 127.262 139.125 83.562  1.00 6.86  ? 149 ASN B ND2 1 
ATOM   4517 N N   . HIS B 2 150 ? 126.264 142.022 87.487  1.00 6.74  ? 150 HIS B N   1 
ATOM   4518 C CA  . HIS B 2 150 ? 126.349 141.596 88.879  1.00 6.74  ? 150 HIS B CA  1 
ATOM   4519 C C   . HIS B 2 150 ? 126.169 142.757 89.851  1.00 6.74  ? 150 HIS B C   1 
ATOM   4520 O O   . HIS B 2 150 ? 126.717 142.739 90.952  1.00 6.74  ? 150 HIS B O   1 
ATOM   4521 C CB  . HIS B 2 150 ? 127.678 140.893 89.148  1.00 6.74  ? 150 HIS B CB  1 
ATOM   4522 C CG  . HIS B 2 150 ? 127.588 139.401 89.134  1.00 6.74  ? 150 HIS B CG  1 
ATOM   4523 N ND1 . HIS B 2 150 ? 127.058 138.678 90.180  1.00 6.74  ? 150 HIS B ND1 1 
ATOM   4524 C CD2 . HIS B 2 150 ? 127.963 138.494 88.202  1.00 6.74  ? 150 HIS B CD2 1 
ATOM   4525 C CE1 . HIS B 2 150 ? 127.108 137.389 89.892  1.00 6.74  ? 150 HIS B CE1 1 
ATOM   4526 N NE2 . HIS B 2 150 ? 127.652 137.251 88.697  1.00 6.74  ? 150 HIS B NE2 1 
ATOM   4527 N N   . GLU B 2 151 ? 125.399 143.770 89.468  1.00 8.91  ? 151 GLU B N   1 
ATOM   4528 C CA  . GLU B 2 151 ? 125.144 144.925 90.320  1.00 8.91  ? 151 GLU B CA  1 
ATOM   4529 C C   . GLU B 2 151 ? 123.676 144.992 90.720  1.00 8.91  ? 151 GLU B C   1 
ATOM   4530 O O   . GLU B 2 151 ? 123.053 146.056 90.711  1.00 8.91  ? 151 GLU B O   1 
ATOM   4531 C CB  . GLU B 2 151 ? 125.572 146.217 89.632  1.00 8.91  ? 151 GLU B CB  1 
ATOM   4532 C CG  . GLU B 2 151 ? 127.064 146.342 89.450  1.00 8.91  ? 151 GLU B CG  1 
ATOM   4533 C CD  . GLU B 2 151 ? 127.509 145.829 88.108  1.00 8.91  ? 151 GLU B CD  1 
ATOM   4534 O OE1 . GLU B 2 151 ? 127.337 144.623 87.848  1.00 8.91  ? 151 GLU B OE1 1 
ATOM   4535 O OE2 . GLU B 2 151 ? 128.017 146.634 87.304  1.00 8.91  ? 151 GLU B OE2 1 
ATOM   4536 N N   . CYS B 2 152 ? 123.110 143.846 91.075  1.00 10.28 ? 152 CYS B N   1 
ATOM   4537 C CA  . CYS B 2 152 ? 121.724 143.738 91.490  1.00 10.28 ? 152 CYS B CA  1 
ATOM   4538 C C   . CYS B 2 152 ? 121.666 143.318 92.952  1.00 10.28 ? 152 CYS B C   1 
ATOM   4539 O O   . CYS B 2 152 ? 122.680 142.985 93.568  1.00 10.28 ? 152 CYS B O   1 
ATOM   4540 C CB  . CYS B 2 152 ? 120.969 142.732 90.614  1.00 10.28 ? 152 CYS B CB  1 
ATOM   4541 S SG  . CYS B 2 152 ? 120.992 143.115 88.849  1.00 10.28 ? 152 CYS B SG  1 
ATOM   4542 N N   . ARG B 2 153 ? 120.457 143.352 93.514  1.00 14.13 ? 153 ARG B N   1 
ATOM   4543 C CA  . ARG B 2 153 ? 120.268 142.835 94.865  1.00 14.13 ? 153 ARG B CA  1 
ATOM   4544 C C   . ARG B 2 153 ? 120.277 141.312 94.876  1.00 14.13 ? 153 ARG B C   1 
ATOM   4545 O O   . ARG B 2 153 ? 120.880 140.694 95.763  1.00 14.13 ? 153 ARG B O   1 
ATOM   4546 C CB  . ARG B 2 153 ? 118.963 143.368 95.455  1.00 14.13 ? 153 ARG B CB  1 
ATOM   4547 C CG  . ARG B 2 153 ? 119.084 144.742 96.094  1.00 14.13 ? 153 ARG B CG  1 
ATOM   4548 C CD  . ARG B 2 153 ? 118.922 145.839 95.057  1.00 14.13 ? 153 ARG B CD  1 
ATOM   4549 N NE  . ARG B 2 153 ? 118.971 147.175 95.644  1.00 14.13 ? 153 ARG B NE  1 
ATOM   4550 C CZ  . ARG B 2 153 ? 118.872 148.298 94.941  1.00 14.13 ? 153 ARG B CZ  1 
ATOM   4551 N NH1 . ARG B 2 153 ? 118.717 148.244 93.625  1.00 14.13 ? 153 ARG B NH1 1 
ATOM   4552 N NH2 . ARG B 2 153 ? 118.927 149.474 95.550  1.00 14.13 ? 153 ARG B NH2 1 
ATOM   4553 N N   . HIS B 2 154 ? 119.629 140.692 93.886  1.00 12.97 ? 154 HIS B N   1 
ATOM   4554 C CA  . HIS B 2 154 ? 119.490 139.239 93.872  1.00 12.97 ? 154 HIS B CA  1 
ATOM   4555 C C   . HIS B 2 154 ? 120.843 138.549 93.764  1.00 12.97 ? 154 HIS B C   1 
ATOM   4556 O O   . HIS B 2 154 ? 121.175 137.680 94.578  1.00 12.97 ? 154 HIS B O   1 
ATOM   4557 C CB  . HIS B 2 154 ? 118.585 138.815 92.715  1.00 12.97 ? 154 HIS B CB  1 
ATOM   4558 C CG  . HIS B 2 154 ? 117.164 138.571 93.117  1.00 12.97 ? 154 HIS B CG  1 
ATOM   4559 N ND1 . HIS B 2 154 ? 116.800 137.572 93.994  1.00 12.97 ? 154 HIS B ND1 1 
ATOM   4560 C CD2 . HIS B 2 154 ? 116.017 139.196 92.761  1.00 12.97 ? 154 HIS B CD2 1 
ATOM   4561 C CE1 . HIS B 2 154 ? 115.490 137.593 94.161  1.00 12.97 ? 154 HIS B CE1 1 
ATOM   4562 N NE2 . HIS B 2 154 ? 114.991 138.568 93.424  1.00 12.97 ? 154 HIS B NE2 1 
ATOM   4563 N N   . LEU B 2 155 ? 121.643 138.928 92.767  1.00 9.23  ? 155 LEU B N   1 
ATOM   4564 C CA  . LEU B 2 155 ? 122.916 138.251 92.545  1.00 9.23  ? 155 LEU B CA  1 
ATOM   4565 C C   . LEU B 2 155 ? 123.871 138.470 93.711  1.00 9.23  ? 155 LEU B C   1 
ATOM   4566 O O   . LEU B 2 155 ? 124.514 137.527 94.184  1.00 9.23  ? 155 LEU B O   1 
ATOM   4567 C CB  . LEU B 2 155 ? 123.548 138.726 91.238  1.00 9.23  ? 155 LEU B CB  1 
ATOM   4568 C CG  . LEU B 2 155 ? 123.124 138.032 89.943  1.00 9.23  ? 155 LEU B CG  1 
ATOM   4569 C CD1 . LEU B 2 155 ? 123.523 136.569 89.986  1.00 9.23  ? 155 LEU B CD1 1 
ATOM   4570 C CD2 . LEU B 2 155 ? 121.636 138.180 89.674  1.00 9.23  ? 155 LEU B CD2 1 
ATOM   4571 N N   . THR B 2 156 ? 123.974 139.709 94.192  1.00 8.47  ? 156 THR B N   1 
ATOM   4572 C CA  . THR B 2 156 ? 124.916 140.001 95.267  1.00 8.47  ? 156 THR B CA  1 
ATOM   4573 C C   . THR B 2 156 ? 124.501 139.330 96.568  1.00 8.47  ? 156 THR B C   1 
ATOM   4574 O O   . THR B 2 156 ? 125.358 138.871 97.332  1.00 8.47  ? 156 THR B O   1 
ATOM   4575 C CB  . THR B 2 156 ? 125.047 141.506 95.456  1.00 8.47  ? 156 THR B CB  1 
ATOM   4576 O OG1 . THR B 2 156 ? 123.742 142.082 95.574  1.00 8.47  ? 156 THR B OG1 1 
ATOM   4577 C CG2 . THR B 2 156 ? 125.764 142.116 94.267  1.00 8.47  ? 156 THR B CG2 1 
ATOM   4578 N N   . GLU B 2 157 ? 123.198 139.267 96.848  1.00 8.62  ? 157 GLU B N   1 
ATOM   4579 C CA  . GLU B 2 157 ? 122.746 138.479 97.990  1.00 8.62  ? 157 GLU B CA  1 
ATOM   4580 C C   . GLU B 2 157 ? 123.084 137.008 97.794  1.00 8.62  ? 157 GLU B C   1 
ATOM   4581 O O   . GLU B 2 157 ? 123.475 136.318 98.742  1.00 8.62  ? 157 GLU B O   1 
ATOM   4582 C CB  . GLU B 2 157 ? 121.244 138.667 98.199  1.00 8.62  ? 157 GLU B CB  1 
ATOM   4583 N N   . TYR B 2 158 ? 122.940 136.514 96.563  1.00 7.66  ? 158 TYR B N   1 
ATOM   4584 C CA  . TYR B 2 158 ? 123.281 135.129 96.262  1.00 7.66  ? 158 TYR B CA  1 
ATOM   4585 C C   . TYR B 2 158 ? 124.771 134.872 96.447  1.00 7.66  ? 158 TYR B C   1 
ATOM   4586 O O   . TYR B 2 158 ? 125.166 133.843 97.007  1.00 7.66  ? 158 TYR B O   1 
ATOM   4587 C CB  . TYR B 2 158 ? 122.847 134.801 94.834  1.00 7.66  ? 158 TYR B CB  1 
ATOM   4588 C CG  . TYR B 2 158 ? 122.972 133.351 94.432  1.00 7.66  ? 158 TYR B CG  1 
ATOM   4589 C CD1 . TYR B 2 158 ? 122.976 132.339 95.380  1.00 7.66  ? 158 TYR B CD1 1 
ATOM   4590 C CD2 . TYR B 2 158 ? 123.077 132.995 93.096  1.00 7.66  ? 158 TYR B CD2 1 
ATOM   4591 C CE1 . TYR B 2 158 ? 123.088 131.015 95.008  1.00 7.66  ? 158 TYR B CE1 1 
ATOM   4592 C CE2 . TYR B 2 158 ? 123.188 131.677 92.714  1.00 7.66  ? 158 TYR B CE2 1 
ATOM   4593 C CZ  . TYR B 2 158 ? 123.194 130.691 93.673  1.00 7.66  ? 158 TYR B CZ  1 
ATOM   4594 O OH  . TYR B 2 158 ? 123.305 129.374 93.293  1.00 7.66  ? 158 TYR B OH  1 
ATOM   4595 N N   . PHE B 2 159 ? 125.611 135.794 95.990  1.00 6.43  ? 159 PHE B N   1 
ATOM   4596 C CA  . PHE B 2 159 ? 127.053 135.600 95.981  1.00 6.43  ? 159 PHE B CA  1 
ATOM   4597 C C   . PHE B 2 159 ? 127.681 136.165 97.256  1.00 6.43  ? 159 PHE B C   1 
ATOM   4598 O O   . PHE B 2 159 ? 127.002 136.430 98.250  1.00 6.43  ? 159 PHE B O   1 
ATOM   4599 C CB  . PHE B 2 159 ? 127.656 136.218 94.725  1.00 6.43  ? 159 PHE B CB  1 
ATOM   4600 C CG  . PHE B 2 159 ? 127.563 135.335 93.521  1.00 6.43  ? 159 PHE B CG  1 
ATOM   4601 C CD1 . PHE B 2 159 ? 126.358 135.163 92.867  1.00 6.43  ? 159 PHE B CD1 1 
ATOM   4602 C CD2 . PHE B 2 159 ? 128.676 134.669 93.049  1.00 6.43  ? 159 PHE B CD2 1 
ATOM   4603 C CE1 . PHE B 2 159 ? 126.268 134.351 91.760  1.00 6.43  ? 159 PHE B CE1 1 
ATOM   4604 C CE2 . PHE B 2 159 ? 128.591 133.856 91.943  1.00 6.43  ? 159 PHE B CE2 1 
ATOM   4605 C CZ  . PHE B 2 159 ? 127.385 133.696 91.298  1.00 6.43  ? 159 PHE B CZ  1 
ATOM   4606 N N   . THR B 2 160 ? 129.001 136.339 97.235  1.00 4.94  ? 160 THR B N   1 
ATOM   4607 C CA  . THR B 2 160 ? 129.788 136.688 98.416  1.00 4.94  ? 160 THR B CA  1 
ATOM   4608 C C   . THR B 2 160 ? 130.111 138.176 98.495  1.00 4.94  ? 160 THR B C   1 
ATOM   4609 O O   . THR B 2 160 ? 131.202 138.553 98.929  1.00 4.94  ? 160 THR B O   1 
ATOM   4610 C CB  . THR B 2 160 ? 131.073 135.866 98.448  1.00 4.94  ? 160 THR B CB  1 
ATOM   4611 O OG1 . THR B 2 160 ? 131.899 136.306 99.533  1.00 4.94  ? 160 THR B OG1 1 
ATOM   4612 C CG2 . THR B 2 160 ? 131.837 136.013 97.141  1.00 4.94  ? 160 THR B CG2 1 
ATOM   4613 N N   . PHE B 2 161 ? 129.199 139.054 98.082  1.00 9.38  ? 161 PHE B N   1 
ATOM   4614 C CA  . PHE B 2 161 ? 129.390 140.481 98.312  1.00 9.38  ? 161 PHE B CA  1 
ATOM   4615 C C   . PHE B 2 161 ? 128.695 140.978 99.569  1.00 9.38  ? 161 PHE B C   1 
ATOM   4616 O O   . PHE B 2 161 ? 129.227 141.853 100.254 1.00 9.38  ? 161 PHE B O   1 
ATOM   4617 C CB  . PHE B 2 161 ? 128.900 141.307 97.123  1.00 9.38  ? 161 PHE B CB  1 
ATOM   4618 C CG  . PHE B 2 161 ? 129.062 142.788 97.319  1.00 9.38  ? 161 PHE B CG  1 
ATOM   4619 C CD1 . PHE B 2 161 ? 127.964 143.605 97.478  1.00 9.38  ? 161 PHE B CD1 1 
ATOM   4620 C CD2 . PHE B 2 161 ? 130.317 143.358 97.369  1.00 9.38  ? 161 PHE B CD2 1 
ATOM   4621 C CE1 . PHE B 2 161 ? 128.117 144.960 97.667  1.00 9.38  ? 161 PHE B CE1 1 
ATOM   4622 C CE2 . PHE B 2 161 ? 130.471 144.712 97.559  1.00 9.38  ? 161 PHE B CE2 1 
ATOM   4623 C CZ  . PHE B 2 161 ? 129.371 145.511 97.708  1.00 9.38  ? 161 PHE B CZ  1 
ATOM   4624 N N   . LYS B 2 162 ? 127.509 140.453 99.882  1.00 6.24  ? 162 LYS B N   1 
ATOM   4625 C CA  . LYS B 2 162 ? 126.824 140.871 101.100 1.00 6.24  ? 162 LYS B CA  1 
ATOM   4626 C C   . LYS B 2 162 ? 127.646 140.522 102.332 1.00 6.24  ? 162 LYS B C   1 
ATOM   4627 O O   . LYS B 2 162 ? 127.738 141.317 103.275 1.00 6.24  ? 162 LYS B O   1 
ATOM   4628 C CB  . LYS B 2 162 ? 125.442 140.226 101.173 1.00 6.24  ? 162 LYS B CB  1 
ATOM   4629 C CG  . LYS B 2 162 ? 124.474 140.932 102.100 1.00 6.24  ? 162 LYS B CG  1 
ATOM   4630 C CD  . LYS B 2 162 ? 123.055 140.435 101.882 1.00 6.24  ? 162 LYS B CD  1 
ATOM   4631 C CE  . LYS B 2 162 ? 122.064 141.176 102.762 1.00 6.24  ? 162 LYS B CE  1 
ATOM   4632 N NZ  . LYS B 2 162 ? 120.664 140.733 102.521 1.00 6.24  ? 162 LYS B NZ  1 
ATOM   4633 N N   . GLN B 2 163 ? 128.258 139.337 102.338 1.00 6.43  ? 163 GLN B N   1 
ATOM   4634 C CA  . GLN B 2 163 ? 129.106 138.952 103.457 1.00 6.43  ? 163 GLN B CA  1 
ATOM   4635 C C   . GLN B 2 163 ? 130.356 139.819 103.530 1.00 6.43  ? 163 GLN B C   1 
ATOM   4636 O O   . GLN B 2 163 ? 130.835 140.116 104.628 1.00 6.43  ? 163 GLN B O   1 
ATOM   4637 C CB  . GLN B 2 163 ? 129.480 137.476 103.344 1.00 6.43  ? 163 GLN B CB  1 
ATOM   4638 C CG  . GLN B 2 163 ? 130.100 136.899 104.597 1.00 6.43  ? 163 GLN B CG  1 
ATOM   4639 C CD  . GLN B 2 163 ? 129.155 136.940 105.780 1.00 6.43  ? 163 GLN B CD  1 
ATOM   4640 O OE1 . GLN B 2 163 ? 129.571 137.165 106.915 1.00 6.43  ? 163 GLN B OE1 1 
ATOM   4641 N NE2 . GLN B 2 163 ? 127.873 136.720 105.518 1.00 6.43  ? 163 GLN B NE2 1 
ATOM   4642 N N   . GLU B 2 164 ? 130.894 140.229 102.377 1.00 5.17  ? 164 GLU B N   1 
ATOM   4643 C CA  . GLU B 2 164 ? 131.987 141.198 102.355 1.00 5.17  ? 164 GLU B CA  1 
ATOM   4644 C C   . GLU B 2 164 ? 131.622 142.454 103.133 1.00 5.17  ? 164 GLU B C   1 
ATOM   4645 O O   . GLU B 2 164 ? 132.352 142.878 104.039 1.00 5.17  ? 164 GLU B O   1 
ATOM   4646 C CB  . GLU B 2 164 ? 132.325 141.557 100.907 1.00 5.17  ? 164 GLU B CB  1 
ATOM   4647 C CG  . GLU B 2 164 ? 133.450 142.570 100.717 1.00 5.17  ? 164 GLU B CG  1 
ATOM   4648 C CD  . GLU B 2 164 ? 134.801 142.071 101.154 1.00 5.17  ? 164 GLU B CD  1 
ATOM   4649 O OE1 . GLU B 2 164 ? 135.012 140.848 101.141 1.00 5.17  ? 164 GLU B OE1 1 
ATOM   4650 O OE2 . GLU B 2 164 ? 135.660 142.905 101.500 1.00 5.17  ? 164 GLU B OE2 1 
ATOM   4651 N N   . CYS B 2 165 ? 130.477 143.051 102.803 1.00 6.97  ? 165 CYS B N   1 
ATOM   4652 C CA  . CYS B 2 165 ? 130.063 144.273 103.476 1.00 6.97  ? 165 CYS B CA  1 
ATOM   4653 C C   . CYS B 2 165 ? 129.795 144.027 104.953 1.00 6.97  ? 165 CYS B C   1 
ATOM   4654 O O   . CYS B 2 165 ? 130.173 144.842 105.798 1.00 6.97  ? 165 CYS B O   1 
ATOM   4655 C CB  . CYS B 2 165 ? 128.828 144.855 102.793 1.00 6.97  ? 165 CYS B CB  1 
ATOM   4656 S SG  . CYS B 2 165 ? 129.202 145.858 101.345 1.00 6.97  ? 165 CYS B SG  1 
ATOM   4657 N N   . LYS B 2 166 ? 129.147 142.907 105.286 1.00 7.60  ? 166 LYS B N   1 
ATOM   4658 C CA  . LYS B 2 166 ? 128.805 142.646 106.682 1.00 7.60  ? 166 LYS B CA  1 
ATOM   4659 C C   . LYS B 2 166 ? 130.046 142.438 107.542 1.00 7.60  ? 166 LYS B C   1 
ATOM   4660 O O   . LYS B 2 166 ? 130.122 142.952 108.664 1.00 7.60  ? 166 LYS B O   1 
ATOM   4661 C CB  . LYS B 2 166 ? 127.880 141.435 106.783 1.00 7.60  ? 166 LYS B CB  1 
ATOM   4662 C CG  . LYS B 2 166 ? 126.412 141.761 106.593 1.00 7.60  ? 166 LYS B CG  1 
ATOM   4663 C CD  . LYS B 2 166 ? 125.546 140.541 106.844 1.00 7.60  ? 166 LYS B CD  1 
ATOM   4664 C CE  . LYS B 2 166 ? 124.080 140.917 106.917 1.00 7.60  ? 166 LYS B CE  1 
ATOM   4665 N NZ  . LYS B 2 166 ? 123.603 141.491 105.632 1.00 7.60  ? 166 LYS B NZ  1 
ATOM   4666 N N   . ILE B 2 167 ? 131.024 141.677 107.046 1.00 5.96  ? 167 ILE B N   1 
ATOM   4667 C CA  . ILE B 2 167 ? 132.231 141.423 107.825 1.00 5.96  ? 167 ILE B CA  1 
ATOM   4668 C C   . ILE B 2 167 ? 133.086 142.679 107.920 1.00 5.96  ? 167 ILE B C   1 
ATOM   4669 O O   . ILE B 2 167 ? 133.577 143.034 108.998 1.00 5.96  ? 167 ILE B O   1 
ATOM   4670 C CB  . ILE B 2 167 ? 133.023 140.248 107.226 1.00 5.96  ? 167 ILE B CB  1 
ATOM   4671 C CG1 . ILE B 2 167 ? 132.217 138.958 107.347 1.00 5.96  ? 167 ILE B CG1 1 
ATOM   4672 C CG2 . ILE B 2 167 ? 134.366 140.107 107.914 1.00 5.96  ? 167 ILE B CG2 1 
ATOM   4673 C CD1 . ILE B 2 167 ? 131.901 138.578 108.774 1.00 5.96  ? 167 ILE B CD1 1 
ATOM   4674 N N   . LYS B 2 168 ? 133.277 143.375 106.799 1.00 5.90  ? 168 LYS B N   1 
ATOM   4675 C CA  . LYS B 2 168 ? 134.181 144.519 106.820 1.00 5.90  ? 168 LYS B CA  1 
ATOM   4676 C C   . LYS B 2 168 ? 133.515 145.750 107.424 1.00 5.90  ? 168 LYS B C   1 
ATOM   4677 O O   . LYS B 2 168 ? 134.083 146.395 108.311 1.00 5.90  ? 168 LYS B O   1 
ATOM   4678 C CB  . LYS B 2 168 ? 134.689 144.808 105.409 1.00 5.90  ? 168 LYS B CB  1 
ATOM   4679 C CG  . LYS B 2 168 ? 135.677 143.771 104.905 1.00 5.90  ? 168 LYS B CG  1 
ATOM   4680 C CD  . LYS B 2 168 ? 136.810 144.414 104.133 1.00 5.90  ? 168 LYS B CD  1 
ATOM   4681 C CE  . LYS B 2 168 ? 137.830 143.380 103.695 1.00 5.90  ? 168 LYS B CE  1 
ATOM   4682 N NZ  . LYS B 2 168 ? 138.941 144.000 102.926 1.00 5.90  ? 168 LYS B NZ  1 
ATOM   4683 N N   . TYR B 2 169 ? 132.310 146.079 106.975 1.00 8.85  ? 169 TYR B N   1 
ATOM   4684 C CA  . TYR B 2 169 ? 131.599 147.289 107.374 1.00 8.85  ? 169 TYR B CA  1 
ATOM   4685 C C   . TYR B 2 169 ? 130.222 146.910 107.922 1.00 8.85  ? 169 TYR B C   1 
ATOM   4686 O O   . TYR B 2 169 ? 129.952 145.750 108.239 1.00 8.85  ? 169 TYR B O   1 
ATOM   4687 C CB  . TYR B 2 169 ? 131.479 148.266 106.200 1.00 8.85  ? 169 TYR B CB  1 
ATOM   4688 C CG  . TYR B 2 169 ? 132.793 148.772 105.642 1.00 8.85  ? 169 TYR B CG  1 
ATOM   4689 C CD1 . TYR B 2 169 ? 132.860 149.306 104.367 1.00 8.85  ? 169 TYR B CD1 1 
ATOM   4690 C CD2 . TYR B 2 169 ? 133.957 148.733 106.392 1.00 8.85  ? 169 TYR B CD2 1 
ATOM   4691 C CE1 . TYR B 2 169 ? 134.051 149.769 103.850 1.00 8.85  ? 169 TYR B CE1 1 
ATOM   4692 C CE2 . TYR B 2 169 ? 135.152 149.192 105.880 1.00 8.85  ? 169 TYR B CE2 1 
ATOM   4693 C CZ  . TYR B 2 169 ? 135.192 149.710 104.610 1.00 8.85  ? 169 TYR B CZ  1 
ATOM   4694 O OH  . TYR B 2 169 ? 136.380 150.172 104.097 1.00 8.85  ? 169 TYR B OH  1 
ATOM   4695 N N   . SER B 2 170 ? 129.364 147.910 108.077 1.00 14.24 ? 170 SER B N   1 
ATOM   4696 C CA  . SER B 2 170 ? 127.978 147.671 108.448 1.00 14.24 ? 170 SER B CA  1 
ATOM   4697 C C   . SER B 2 170 ? 127.115 147.509 107.200 1.00 14.24 ? 170 SER B C   1 
ATOM   4698 O O   . SER B 2 170 ? 127.487 147.921 106.100 1.00 14.24 ? 170 SER B O   1 
ATOM   4699 C CB  . SER B 2 170 ? 127.442 148.815 109.308 1.00 14.24 ? 170 SER B CB  1 
ATOM   4700 O OG  . SER B 2 170 ? 127.012 149.897 108.501 1.00 14.24 ? 170 SER B OG  1 
ATOM   4701 N N   . GLU B 2 171 ? 125.938 146.907 107.391 1.00 16.66 ? 171 GLU B N   1 
ATOM   4702 C CA  . GLU B 2 171 ? 125.019 146.674 106.281 1.00 16.66 ? 171 GLU B CA  1 
ATOM   4703 C C   . GLU B 2 171 ? 124.533 147.978 105.653 1.00 16.66 ? 171 GLU B C   1 
ATOM   4704 O O   . GLU B 2 171 ? 124.078 147.974 104.501 1.00 16.66 ? 171 GLU B O   1 
ATOM   4705 C CB  . GLU B 2 171 ? 123.840 145.826 106.771 1.00 16.66 ? 171 GLU B CB  1 
ATOM   4706 C CG  . GLU B 2 171 ? 122.951 145.237 105.684 1.00 16.66 ? 171 GLU B CG  1 
ATOM   4707 C CD  . GLU B 2 171 ? 121.797 146.145 105.310 1.00 16.66 ? 171 GLU B CD  1 
ATOM   4708 O OE1 . GLU B 2 171 ? 121.367 146.944 106.168 1.00 16.66 ? 171 GLU B OE1 1 
ATOM   4709 O OE2 . GLU B 2 171 ? 121.311 146.053 104.163 1.00 16.66 ? 171 GLU B OE2 1 
ATOM   4710 N N   . ARG B 2 172 ? 124.629 149.094 106.380 1.00 16.88 ? 172 ARG B N   1 
ATOM   4711 C CA  . ARG B 2 172 ? 124.293 150.386 105.794 1.00 16.88 ? 172 ARG B CA  1 
ATOM   4712 C C   . ARG B 2 172 ? 125.201 150.702 104.612 1.00 16.88 ? 172 ARG B C   1 
ATOM   4713 O O   . ARG B 2 172 ? 124.764 151.311 103.628 1.00 16.88 ? 172 ARG B O   1 
ATOM   4714 C CB  . ARG B 2 172 ? 124.387 151.484 106.853 1.00 16.88 ? 172 ARG B CB  1 
ATOM   4715 C CG  . ARG B 2 172 ? 123.569 151.227 108.115 1.00 16.88 ? 172 ARG B CG  1 
ATOM   4716 C CD  . ARG B 2 172 ? 122.146 150.790 107.801 1.00 16.88 ? 172 ARG B CD  1 
ATOM   4717 N NE  . ARG B 2 172 ? 121.495 151.672 106.836 1.00 16.88 ? 172 ARG B NE  1 
ATOM   4718 C CZ  . ARG B 2 172 ? 120.882 151.247 105.737 1.00 16.88 ? 172 ARG B CZ  1 
ATOM   4719 N NH1 . ARG B 2 172 ? 120.831 149.950 105.467 1.00 16.88 ? 172 ARG B NH1 1 
ATOM   4720 N NH2 . ARG B 2 172 ? 120.317 152.115 104.909 1.00 16.88 ? 172 ARG B NH2 1 
ATOM   4721 N N   . VAL B 2 173 ? 126.470 150.294 104.693 1.00 15.99 ? 173 VAL B N   1 
ATOM   4722 C CA  . VAL B 2 173 ? 127.377 150.442 103.558 1.00 15.99 ? 173 VAL B CA  1 
ATOM   4723 C C   . VAL B 2 173 ? 126.861 149.650 102.365 1.00 15.99 ? 173 VAL B C   1 
ATOM   4724 O O   . VAL B 2 173 ? 126.888 150.127 101.225 1.00 15.99 ? 173 VAL B O   1 
ATOM   4725 C CB  . VAL B 2 173 ? 128.802 150.010 103.951 1.00 15.99 ? 173 VAL B CB  1 
ATOM   4726 C CG1 . VAL B 2 173 ? 129.697 149.945 102.725 1.00 15.99 ? 173 VAL B CG1 1 
ATOM   4727 C CG2 . VAL B 2 173 ? 129.373 150.964 104.980 1.00 15.99 ? 173 VAL B CG2 1 
ATOM   4728 N N   . TYR B 2 174 ? 126.382 148.430 102.611 1.00 13.03 ? 174 TYR B N   1 
ATOM   4729 C CA  . TYR B 2 174 ? 125.791 147.630 101.545 1.00 13.03 ? 174 TYR B CA  1 
ATOM   4730 C C   . TYR B 2 174 ? 124.616 148.351 100.897 1.00 13.03 ? 174 TYR B C   1 
ATOM   4731 O O   . TYR B 2 174 ? 124.522 148.432 99.665  1.00 13.03 ? 174 TYR B O   1 
ATOM   4732 C CB  . TYR B 2 174 ? 125.344 146.281 102.104 1.00 13.03 ? 174 TYR B CB  1 
ATOM   4733 C CG  . TYR B 2 174 ? 124.749 145.363 101.071 1.00 13.03 ? 174 TYR B CG  1 
ATOM   4734 C CD1 . TYR B 2 174 ? 125.551 144.694 100.167 1.00 13.03 ? 174 TYR B CD1 1 
ATOM   4735 C CD2 . TYR B 2 174 ? 123.377 145.183 100.988 1.00 13.03 ? 174 TYR B CD2 1 
ATOM   4736 C CE1 . TYR B 2 174 ? 125.007 143.858 99.222  1.00 13.03 ? 174 TYR B CE1 1 
ATOM   4737 C CE2 . TYR B 2 174 ? 122.824 144.352 100.043 1.00 13.03 ? 174 TYR B CE2 1 
ATOM   4738 C CZ  . TYR B 2 174 ? 123.644 143.692 99.160  1.00 13.03 ? 174 TYR B CZ  1 
ATOM   4739 O OH  . TYR B 2 174 ? 123.103 142.858 98.211  1.00 13.03 ? 174 TYR B OH  1 
ATOM   4740 N N   . ASP B 2 175 ? 123.705 148.881 101.716 1.00 16.40 ? 175 ASP B N   1 
ATOM   4741 C CA  . ASP B 2 175 ? 122.522 149.534 101.162 1.00 16.40 ? 175 ASP B CA  1 
ATOM   4742 C C   . ASP B 2 175 ? 122.898 150.775 100.362 1.00 16.40 ? 175 ASP B C   1 
ATOM   4743 O O   . ASP B 2 175 ? 122.337 151.023 99.286  1.00 16.40 ? 175 ASP B O   1 
ATOM   4744 C CB  . ASP B 2 175 ? 121.545 149.897 102.276 1.00 16.40 ? 175 ASP B CB  1 
ATOM   4745 C CG  . ASP B 2 175 ? 120.372 150.712 101.775 1.00 16.40 ? 175 ASP B CG  1 
ATOM   4746 O OD1 . ASP B 2 175 ? 119.861 150.404 100.678 1.00 16.40 ? 175 ASP B OD1 1 
ATOM   4747 O OD2 . ASP B 2 175 ? 119.963 151.663 102.473 1.00 16.40 ? 175 ASP B OD2 1 
ATOM   4748 N N   . ALA B 2 176 ? 123.840 151.570 100.875 1.00 16.45 ? 176 ALA B N   1 
ATOM   4749 C CA  . ALA B 2 176 ? 124.287 152.750 100.144 1.00 16.45 ? 176 ALA B CA  1 
ATOM   4750 C C   . ALA B 2 176 ? 124.943 152.362 98.826  1.00 16.45 ? 176 ALA B C   1 
ATOM   4751 O O   . ALA B 2 176 ? 124.697 152.992 97.790  1.00 16.45 ? 176 ALA B O   1 
ATOM   4752 C CB  . ALA B 2 176 ? 125.246 153.570 101.006 1.00 16.45 ? 176 ALA B CB  1 
ATOM   4753 N N   . CYS B 2 177 ? 125.763 151.309 98.838  1.00 14.38 ? 177 CYS B N   1 
ATOM   4754 C CA  . CYS B 2 177 ? 126.430 150.880 97.615  1.00 14.38 ? 177 CYS B CA  1 
ATOM   4755 C C   . CYS B 2 177 ? 125.421 150.389 96.586  1.00 14.38 ? 177 CYS B C   1 
ATOM   4756 O O   . CYS B 2 177 ? 125.607 150.586 95.381  1.00 14.38 ? 177 CYS B O   1 
ATOM   4757 C CB  . CYS B 2 177 ? 127.458 149.796 97.933  1.00 14.38 ? 177 CYS B CB  1 
ATOM   4758 S SG  . CYS B 2 177 ? 128.472 149.294 96.533  1.00 14.38 ? 177 CYS B SG  1 
ATOM   4759 N N   . MET B 2 178 ? 124.340 149.754 97.039  1.00 15.68 ? 178 MET B N   1 
ATOM   4760 C CA  . MET B 2 178 ? 123.322 149.306 96.092  1.00 15.68 ? 178 MET B CA  1 
ATOM   4761 C C   . MET B 2 178 ? 122.528 150.477 95.529  1.00 15.68 ? 178 MET B C   1 
ATOM   4762 O O   . MET B 2 178 ? 122.287 150.548 94.315  1.00 15.68 ? 178 MET B O   1 
ATOM   4763 C CB  . MET B 2 178 ? 122.402 148.286 96.753  1.00 15.68 ? 178 MET B CB  1 
ATOM   4764 C CG  . MET B 2 178 ? 123.120 146.995 97.022  1.00 15.68 ? 178 MET B CG  1 
ATOM   4765 S SD  . MET B 2 178 ? 124.130 146.619 95.584  1.00 15.68 ? 178 MET B SD  1 
ATOM   4766 C CE  . MET B 2 178 ? 124.742 145.012 96.033  1.00 15.68 ? 178 MET B CE  1 
ATOM   4767 N N   . ASP B 2 179 ? 122.120 151.414 96.389  1.00 18.22 ? 179 ASP B N   1 
ATOM   4768 C CA  . ASP B 2 179 ? 121.453 152.613 95.895  1.00 18.22 ? 179 ASP B CA  1 
ATOM   4769 C C   . ASP B 2 179 ? 122.357 153.419 94.976  1.00 18.22 ? 179 ASP B C   1 
ATOM   4770 O O   . ASP B 2 179 ? 121.861 154.227 94.184  1.00 18.22 ? 179 ASP B O   1 
ATOM   4771 C CB  . ASP B 2 179 ? 120.985 153.483 97.062  1.00 18.22 ? 179 ASP B CB  1 
ATOM   4772 C CG  . ASP B 2 179 ? 119.687 152.992 97.670  1.00 18.22 ? 179 ASP B CG  1 
ATOM   4773 O OD1 . ASP B 2 179 ? 118.871 152.399 96.933  1.00 18.22 ? 179 ASP B OD1 1 
ATOM   4774 O OD2 . ASP B 2 179 ? 119.481 153.202 98.884  1.00 18.22 ? 179 ASP B OD2 1 
ATOM   4775 N N   . ALA B 2 180 ? 123.671 153.215 95.070  1.00 15.00 ? 180 ALA B N   1 
ATOM   4776 C CA  . ALA B 2 180 ? 124.601 153.900 94.182  1.00 15.00 ? 180 ALA B CA  1 
ATOM   4777 C C   . ALA B 2 180 ? 124.779 153.160 92.857  1.00 15.00 ? 180 ALA B C   1 
ATOM   4778 O O   . ALA B 2 180 ? 124.862 153.796 91.801  1.00 15.00 ? 180 ALA B O   1 
ATOM   4779 C CB  . ALA B 2 180 ? 125.937 154.077 94.892  1.00 15.00 ? 180 ALA B CB  1 
ATOM   4780 N N   . PHE B 2 181 ? 124.850 151.824 92.892  1.00 15.18 ? 181 PHE B N   1 
ATOM   4781 C CA  . PHE B 2 181 ? 124.789 151.045 91.655  1.00 15.18 ? 181 PHE B CA  1 
ATOM   4782 C C   . PHE B 2 181 ? 123.499 151.295 90.891  1.00 15.18 ? 181 PHE B C   1 
ATOM   4783 O O   . PHE B 2 181 ? 123.462 151.121 89.669  1.00 15.18 ? 181 PHE B O   1 
ATOM   4784 C CB  . PHE B 2 181 ? 124.922 149.544 91.931  1.00 15.18 ? 181 PHE B CB  1 
ATOM   4785 C CG  . PHE B 2 181 ? 126.280 149.114 92.403  1.00 15.18 ? 181 PHE B CG  1 
ATOM   4786 C CD1 . PHE B 2 181 ? 127.374 149.945 92.277  1.00 15.18 ? 181 PHE B CD1 1 
ATOM   4787 C CD2 . PHE B 2 181 ? 126.463 147.854 92.946  1.00 15.18 ? 181 PHE B CD2 1 
ATOM   4788 C CE1 . PHE B 2 181 ? 128.622 149.533 92.698  1.00 15.18 ? 181 PHE B CE1 1 
ATOM   4789 C CE2 . PHE B 2 181 ? 127.707 147.442 93.369  1.00 15.18 ? 181 PHE B CE2 1 
ATOM   4790 C CZ  . PHE B 2 181 ? 128.786 148.282 93.243  1.00 15.18 ? 181 PHE B CZ  1 
ATOM   4791 N N   . ASP B 2 182 ? 122.436 151.697 91.589  1.00 18.01 ? 182 ASP B N   1 
ATOM   4792 C CA  . ASP B 2 182 ? 121.149 151.888 90.929  1.00 18.01 ? 182 ASP B CA  1 
ATOM   4793 C C   . ASP B 2 182 ? 121.201 152.913 89.798  1.00 18.01 ? 182 ASP B C   1 
ATOM   4794 O O   . ASP B 2 182 ? 120.318 152.902 88.935  1.00 18.01 ? 182 ASP B O   1 
ATOM   4795 C CB  . ASP B 2 182 ? 120.093 152.310 91.952  1.00 18.01 ? 182 ASP B CB  1 
ATOM   4796 C CG  . ASP B 2 182 ? 119.474 151.129 92.674  1.00 18.01 ? 182 ASP B CG  1 
ATOM   4797 O OD1 . ASP B 2 182 ? 119.905 149.985 92.422  1.00 18.01 ? 182 ASP B OD1 1 
ATOM   4798 O OD2 . ASP B 2 182 ? 118.558 151.343 93.495  1.00 18.01 ? 182 ASP B OD2 1 
ATOM   4799 N N   . CYS B 2 183 ? 122.200 153.795 89.776  1.00 16.05 ? 183 CYS B N   1 
ATOM   4800 C CA  . CYS B 2 183 ? 122.218 154.917 88.845  1.00 16.05 ? 183 CYS B CA  1 
ATOM   4801 C C   . CYS B 2 183 ? 123.276 154.798 87.752  1.00 16.05 ? 183 CYS B C   1 
ATOM   4802 O O   . CYS B 2 183 ? 123.545 155.787 87.064  1.00 16.05 ? 183 CYS B O   1 
ATOM   4803 C CB  . CYS B 2 183 ? 122.418 156.224 89.614  1.00 16.05 ? 183 CYS B CB  1 
ATOM   4804 S SG  . CYS B 2 183 ? 124.107 156.498 90.198  1.00 16.05 ? 183 CYS B SG  1 
ATOM   4805 N N   . LEU B 2 184 ? 123.876 153.626 87.566  1.00 13.87 ? 184 LEU B N   1 
ATOM   4806 C CA  . LEU B 2 184 ? 124.950 153.497 86.591  1.00 13.87 ? 184 LEU B CA  1 
ATOM   4807 C C   . LEU B 2 184 ? 124.416 153.626 85.163  1.00 13.87 ? 184 LEU B C   1 
ATOM   4808 O O   . LEU B 2 184 ? 123.276 153.251 84.880  1.00 13.87 ? 184 LEU B O   1 
ATOM   4809 C CB  . LEU B 2 184 ? 125.663 152.158 86.759  1.00 13.87 ? 184 LEU B CB  1 
ATOM   4810 C CG  . LEU B 2 184 ? 126.763 152.119 87.819  1.00 13.87 ? 184 LEU B CG  1 
ATOM   4811 C CD1 . LEU B 2 184 ? 126.989 150.709 88.330  1.00 13.87 ? 184 LEU B CD1 1 
ATOM   4812 C CD2 . LEU B 2 184 ? 128.043 152.687 87.249  1.00 13.87 ? 184 LEU B CD2 1 
ATOM   4813 N N   . PRO B 2 185 ? 125.216 154.170 84.249  1.00 12.82 ? 185 PRO B N   1 
ATOM   4814 C CA  . PRO B 2 185 ? 124.825 154.206 82.836  1.00 12.82 ? 185 PRO B CA  1 
ATOM   4815 C C   . PRO B 2 185 ? 125.011 152.842 82.182  1.00 12.82 ? 185 PRO B C   1 
ATOM   4816 O O   . PRO B 2 185 ? 125.654 151.944 82.726  1.00 12.82 ? 185 PRO B O   1 
ATOM   4817 C CB  . PRO B 2 185 ? 125.771 155.248 82.233  1.00 12.82 ? 185 PRO B CB  1 
ATOM   4818 C CG  . PRO B 2 185 ? 126.965 155.215 83.109  1.00 12.82 ? 185 PRO B CG  1 
ATOM   4819 C CD  . PRO B 2 185 ? 126.491 154.864 84.491  1.00 12.82 ? 185 PRO B CD  1 
ATOM   4820 N N   . LEU B 2 186 ? 124.424 152.691 80.989  1.00 16.29 ? 186 LEU B N   1 
ATOM   4821 C CA  . LEU B 2 186 ? 124.397 151.382 80.353  1.00 16.29 ? 186 LEU B CA  1 
ATOM   4822 C C   . LEU B 2 186 ? 124.587 151.354 78.840  1.00 16.29 ? 186 LEU B C   1 
ATOM   4823 O O   . LEU B 2 186 ? 124.488 150.269 78.260  1.00 16.29 ? 186 LEU B O   1 
ATOM   4824 C CB  . LEU B 2 186 ? 123.082 150.665 80.713  1.00 16.29 ? 186 LEU B CB  1 
ATOM   4825 C CG  . LEU B 2 186 ? 121.734 151.272 80.310  1.00 16.29 ? 186 LEU B CG  1 
ATOM   4826 C CD1 . LEU B 2 186 ? 121.337 150.943 78.877  1.00 16.29 ? 186 LEU B CD1 1 
ATOM   4827 C CD2 . LEU B 2 186 ? 120.659 150.803 81.274  1.00 16.29 ? 186 LEU B CD2 1 
ATOM   4828 N N   . ALA B 2 187 ? 124.849 152.478 78.171  1.00 14.90 ? 187 ALA B N   1 
ATOM   4829 C CA  . ALA B 2 187 ? 125.007 152.460 76.719  1.00 14.90 ? 187 ALA B CA  1 
ATOM   4830 C C   . ALA B 2 187 ? 126.414 152.834 76.268  1.00 14.90 ? 187 ALA B C   1 
ATOM   4831 O O   . ALA B 2 187 ? 127.069 152.038 75.592  1.00 14.90 ? 187 ALA B O   1 
ATOM   4832 C CB  . ALA B 2 187 ? 123.973 153.385 76.067  1.00 14.90 ? 187 ALA B CB  1 
ATOM   4833 N N   . ALA B 2 188 ? 126.891 154.032 76.610  1.00 16.30 ? 188 ALA B N   1 
ATOM   4834 C CA  . ALA B 2 188 ? 128.294 154.429 76.451  1.00 16.30 ? 188 ALA B CA  1 
ATOM   4835 C C   . ALA B 2 188 ? 128.774 154.295 75.001  1.00 16.30 ? 188 ALA B C   1 
ATOM   4836 O O   . ALA B 2 188 ? 129.634 153.476 74.671  1.00 16.30 ? 188 ALA B O   1 
ATOM   4837 C CB  . ALA B 2 188 ? 129.191 153.619 77.391  1.00 16.30 ? 188 ALA B CB  1 
ATOM   4838 N N   . LEU B 2 189 ? 128.195 155.124 74.137  1.00 15.70 ? 189 LEU B N   1 
ATOM   4839 C CA  . LEU B 2 189 ? 128.699 155.229 72.774  1.00 15.70 ? 189 LEU B CA  1 
ATOM   4840 C C   . LEU B 2 189 ? 130.103 155.824 72.775  1.00 15.70 ? 189 LEU B C   1 
ATOM   4841 O O   . LEU B 2 189 ? 130.441 156.669 73.607  1.00 15.70 ? 189 LEU B O   1 
ATOM   4842 C CB  . LEU B 2 189 ? 127.767 156.087 71.920  1.00 15.70 ? 189 LEU B CB  1 
ATOM   4843 C CG  . LEU B 2 189 ? 128.143 156.299 70.451  1.00 15.70 ? 189 LEU B CG  1 
ATOM   4844 C CD1 . LEU B 2 189 ? 128.005 155.007 69.664  1.00 15.70 ? 189 LEU B CD1 1 
ATOM   4845 C CD2 . LEU B 2 189 ? 127.299 157.401 69.830  1.00 15.70 ? 189 LEU B CD2 1 
ATOM   4846 N N   . MET B 2 190 ? 130.930 155.373 71.834  1.00 17.83 ? 190 MET B N   1 
ATOM   4847 C CA  . MET B 2 190 ? 132.322 155.803 71.752  1.00 17.83 ? 190 MET B CA  1 
ATOM   4848 C C   . MET B 2 190 ? 132.629 156.272 70.338  1.00 17.83 ? 190 MET B C   1 
ATOM   4849 O O   . MET B 2 190 ? 132.489 155.502 69.383  1.00 17.83 ? 190 MET B O   1 
ATOM   4850 C CB  . MET B 2 190 ? 133.270 154.671 72.159  1.00 17.83 ? 190 MET B CB  1 
ATOM   4851 C CG  . MET B 2 190 ? 134.739 155.059 72.181  1.00 17.83 ? 190 MET B CG  1 
ATOM   4852 S SD  . MET B 2 190 ? 135.588 154.691 70.635  1.00 17.83 ? 190 MET B SD  1 
ATOM   4853 C CE  . MET B 2 190 ? 136.449 153.188 71.080  1.00 17.83 ? 190 MET B CE  1 
ATOM   4854 N N   . ASN B 2 191 ? 133.044 157.535 70.211  1.00 18.70 ? 191 ASN B N   1 
ATOM   4855 C CA  . ASN B 2 191 ? 133.512 158.127 68.956  1.00 18.70 ? 191 ASN B CA  1 
ATOM   4856 C C   . ASN B 2 191 ? 132.465 158.078 67.847  1.00 18.70 ? 191 ASN B C   1 
ATOM   4857 O O   . ASN B 2 191 ? 132.792 158.300 66.676  1.00 18.70 ? 191 ASN B O   1 
ATOM   4858 C CB  . ASN B 2 191 ? 134.807 157.460 68.480  1.00 18.70 ? 191 ASN B CB  1 
ATOM   4859 C CG  . ASN B 2 191 ? 135.634 158.362 67.584  1.00 18.70 ? 191 ASN B CG  1 
ATOM   4860 O OD1 . ASN B 2 191 ? 135.314 159.536 67.402  1.00 18.70 ? 191 ASN B OD1 1 
ATOM   4861 N ND2 . ASN B 2 191 ? 136.702 157.815 67.016  1.00 18.70 ? 191 ASN B ND2 1 
ATOM   4862 N N   . GLN B 2 192 ? 131.209 157.790 68.189  1.00 18.42 ? 192 GLN B N   1 
ATOM   4863 C CA  . GLN B 2 192 ? 130.119 157.650 67.224  1.00 18.42 ? 192 GLN B CA  1 
ATOM   4864 C C   . GLN B 2 192 ? 130.433 156.624 66.137  1.00 18.42 ? 192 GLN B C   1 
ATOM   4865 O O   . GLN B 2 192 ? 129.854 156.673 65.048  1.00 18.42 ? 192 GLN B O   1 
ATOM   4866 C CB  . GLN B 2 192 ? 129.761 158.999 66.589  1.00 18.42 ? 192 GLN B CB  1 
ATOM   4867 N N   . GLN B 2 193 ? 131.348 155.695 66.413  1.00 20.32 ? 193 GLN B N   1 
ATOM   4868 C CA  . GLN B 2 193 ? 131.707 154.655 65.458  1.00 20.32 ? 193 GLN B CA  1 
ATOM   4869 C C   . GLN B 2 193 ? 131.675 153.287 66.126  1.00 20.32 ? 193 GLN B C   1 
ATOM   4870 O O   . GLN B 2 193 ? 131.499 152.263 65.457  1.00 20.32 ? 193 GLN B O   1 
ATOM   4871 C CB  . GLN B 2 193 ? 133.090 154.925 64.863  1.00 20.32 ? 193 GLN B CB  1 
ATOM   4872 C CG  . GLN B 2 193 ? 133.206 156.255 64.140  1.00 20.32 ? 193 GLN B CG  1 
ATOM   4873 C CD  . GLN B 2 193 ? 134.284 156.247 63.076  1.00 20.32 ? 193 GLN B CD  1 
ATOM   4874 O OE1 . GLN B 2 193 ? 134.697 155.189 62.602  1.00 20.32 ? 193 GLN B OE1 1 
ATOM   4875 N NE2 . GLN B 2 193 ? 134.746 157.432 62.693  1.00 20.32 ? 193 GLN B NE2 1 
ATOM   4876 N N   . PHE B 2 194 ? 131.852 153.262 67.444  1.00 18.76 ? 194 PHE B N   1 
ATOM   4877 C CA  . PHE B 2 194 ? 131.830 152.035 68.225  1.00 18.76 ? 194 PHE B CA  1 
ATOM   4878 C C   . PHE B 2 194 ? 130.823 152.163 69.358  1.00 18.76 ? 194 PHE B C   1 
ATOM   4879 O O   . PHE B 2 194 ? 130.674 153.236 69.951  1.00 18.76 ? 194 PHE B O   1 
ATOM   4880 C CB  . PHE B 2 194 ? 133.214 151.722 68.793  1.00 18.76 ? 194 PHE B CB  1 
ATOM   4881 C CG  . PHE B 2 194 ? 134.232 151.379 67.748  1.00 18.76 ? 194 PHE B CG  1 
ATOM   4882 C CD1 . PHE B 2 194 ? 134.285 150.107 67.207  1.00 18.76 ? 194 PHE B CD1 1 
ATOM   4883 C CD2 . PHE B 2 194 ? 135.128 152.332 67.299  1.00 18.76 ? 194 PHE B CD2 1 
ATOM   4884 C CE1 . PHE B 2 194 ? 135.221 149.789 66.244  1.00 18.76 ? 194 PHE B CE1 1 
ATOM   4885 C CE2 . PHE B 2 194 ? 136.065 152.020 66.335  1.00 18.76 ? 194 PHE B CE2 1 
ATOM   4886 C CZ  . PHE B 2 194 ? 136.112 150.747 65.807  1.00 18.76 ? 194 PHE B CZ  1 
ATOM   4887 N N   . LEU B 2 195 ? 130.137 151.065 69.654  1.00 16.88 ? 195 LEU B N   1 
ATOM   4888 C CA  . LEU B 2 195 ? 129.195 150.988 70.761  1.00 16.88 ? 195 LEU B CA  1 
ATOM   4889 C C   . LEU B 2 195 ? 129.693 149.950 71.755  1.00 16.88 ? 195 LEU B C   1 
ATOM   4890 O O   . LEU B 2 195 ? 130.105 148.856 71.358  1.00 16.88 ? 195 LEU B O   1 
ATOM   4891 C CB  . LEU B 2 195 ? 127.795 150.625 70.265  1.00 16.88 ? 195 LEU B CB  1 
ATOM   4892 C CG  . LEU B 2 195 ? 126.690 150.513 71.314  1.00 16.88 ? 195 LEU B CG  1 
ATOM   4893 C CD1 . LEU B 2 195 ? 126.290 151.886 71.819  1.00 16.88 ? 195 LEU B CD1 1 
ATOM   4894 C CD2 . LEU B 2 195 ? 125.491 149.780 70.743  1.00 16.88 ? 195 LEU B CD2 1 
ATOM   4895 N N   . CYS B 2 196 ? 129.665 150.294 73.041  1.00 14.66 ? 196 CYS B N   1 
ATOM   4896 C CA  . CYS B 2 196 ? 130.201 149.434 74.092  1.00 14.66 ? 196 CYS B CA  1 
ATOM   4897 C C   . CYS B 2 196 ? 129.116 149.164 75.126  1.00 14.66 ? 196 CYS B C   1 
ATOM   4898 O O   . CYS B 2 196 ? 128.802 150.033 75.945  1.00 14.66 ? 196 CYS B O   1 
ATOM   4899 C CB  . CYS B 2 196 ? 131.427 150.073 74.739  1.00 14.66 ? 196 CYS B CB  1 
ATOM   4900 S SG  . CYS B 2 196 ? 132.733 150.505 73.570  1.00 14.66 ? 196 CYS B SG  1 
ATOM   4901 N N   . VAL B 2 197 ? 128.560 147.955 75.101  1.00 11.22 ? 197 VAL B N   1 
ATOM   4902 C CA  . VAL B 2 197 ? 127.572 147.512 76.075  1.00 11.22 ? 197 VAL B CA  1 
ATOM   4903 C C   . VAL B 2 197 ? 128.125 146.293 76.799  1.00 11.22 ? 197 VAL B C   1 
ATOM   4904 O O   . VAL B 2 197 ? 128.852 145.482 76.218  1.00 11.22 ? 197 VAL B O   1 
ATOM   4905 C CB  . VAL B 2 197 ? 126.217 147.191 75.414  1.00 11.22 ? 197 VAL B CB  1 
ATOM   4906 C CG1 . VAL B 2 197 ? 125.568 148.463 74.911  1.00 11.22 ? 197 VAL B CG1 1 
ATOM   4907 C CG2 . VAL B 2 197 ? 126.410 146.214 74.272  1.00 11.22 ? 197 VAL B CG2 1 
ATOM   4908 N N   . HIS B 2 198 ? 127.776 146.168 78.082  1.00 11.15 ? 198 HIS B N   1 
ATOM   4909 C CA  . HIS B 2 198 ? 128.391 145.133 78.908  1.00 11.15 ? 198 HIS B CA  1 
ATOM   4910 C C   . HIS B 2 198 ? 128.066 143.737 78.399  1.00 11.15 ? 198 HIS B C   1 
ATOM   4911 O O   . HIS B 2 198 ? 128.937 142.862 78.368  1.00 11.15 ? 198 HIS B O   1 
ATOM   4912 C CB  . HIS B 2 198 ? 127.946 145.269 80.358  1.00 11.15 ? 198 HIS B CB  1 
ATOM   4913 C CG  . HIS B 2 198 ? 128.268 144.070 81.190  1.00 11.15 ? 198 HIS B CG  1 
ATOM   4914 N ND1 . HIS B 2 198 ? 129.560 143.649 81.414  1.00 11.15 ? 198 HIS B ND1 1 
ATOM   4915 C CD2 . HIS B 2 198 ? 127.469 143.200 81.849  1.00 11.15 ? 198 HIS B CD2 1 
ATOM   4916 C CE1 . HIS B 2 198 ? 129.544 142.573 82.178  1.00 11.15 ? 198 HIS B CE1 1 
ATOM   4917 N NE2 . HIS B 2 198 ? 128.288 142.281 82.459  1.00 11.15 ? 198 HIS B NE2 1 
ATOM   4918 N N   . GLY B 2 199 ? 126.819 143.508 78.006  1.00 11.42 ? 199 GLY B N   1 
ATOM   4919 C CA  . GLY B 2 199 ? 126.396 142.202 77.547  1.00 11.42 ? 199 GLY B CA  1 
ATOM   4920 C C   . GLY B 2 199 ? 126.324 142.121 76.039  1.00 11.42 ? 199 GLY B C   1 
ATOM   4921 O O   . GLY B 2 199 ? 127.341 141.913 75.373  1.00 11.42 ? 199 GLY B O   1 
ATOM   4922 N N   . GLY B 2 200 ? 125.127 142.269 75.488  1.00 15.43 ? 200 GLY B N   1 
ATOM   4923 C CA  . GLY B 2 200 ? 124.984 142.205 74.047  1.00 15.43 ? 200 GLY B CA  1 
ATOM   4924 C C   . GLY B 2 200 ? 123.666 142.800 73.611  1.00 15.43 ? 200 GLY B C   1 
ATOM   4925 O O   . GLY B 2 200 ? 122.883 143.303 74.421  1.00 15.43 ? 200 GLY B O   1 
ATOM   4926 N N   . LEU B 2 201 ? 123.436 142.732 72.305  1.00 19.44 ? 201 LEU B N   1 
ATOM   4927 C CA  . LEU B 2 201 ? 122.222 143.267 71.714  1.00 19.44 ? 201 LEU B CA  1 
ATOM   4928 C C   . LEU B 2 201 ? 121.014 142.421 72.104  1.00 19.44 ? 201 LEU B C   1 
ATOM   4929 O O   . LEU B 2 201 ? 121.135 141.274 72.543  1.00 19.44 ? 201 LEU B O   1 
ATOM   4930 C CB  . LEU B 2 201 ? 122.347 143.308 70.193  1.00 19.44 ? 201 LEU B CB  1 
ATOM   4931 C CG  . LEU B 2 201 ? 123.343 144.301 69.601  1.00 19.44 ? 201 LEU B CG  1 
ATOM   4932 C CD1 . LEU B 2 201 ? 123.111 144.424 68.111  1.00 19.44 ? 201 LEU B CD1 1 
ATOM   4933 C CD2 . LEU B 2 201 ? 123.223 145.656 70.279  1.00 19.44 ? 201 LEU B CD2 1 
ATOM   4934 N N   . SER B 2 202 ? 119.834 143.008 71.939  1.00 20.50 ? 202 SER B N   1 
ATOM   4935 C CA  . SER B 2 202 ? 118.580 142.303 72.138  1.00 20.50 ? 202 SER B CA  1 
ATOM   4936 C C   . SER B 2 202 ? 117.652 142.577 70.966  1.00 20.50 ? 202 SER B C   1 
ATOM   4937 O O   . SER B 2 202 ? 117.670 143.673 70.395  1.00 20.50 ? 202 SER B O   1 
ATOM   4938 C CB  . SER B 2 202 ? 117.899 142.730 73.445  1.00 20.50 ? 202 SER B CB  1 
ATOM   4939 O OG  . SER B 2 202 ? 117.189 143.944 73.278  1.00 20.50 ? 202 SER B OG  1 
ATOM   4940 N N   . PRO B 2 203 ? 116.838 141.593 70.576  1.00 20.28 ? 203 PRO B N   1 
ATOM   4941 C CA  . PRO B 2 203 ? 115.887 141.826 69.476  1.00 20.28 ? 203 PRO B CA  1 
ATOM   4942 C C   . PRO B 2 203 ? 114.883 142.923 69.774  1.00 20.28 ? 203 PRO B C   1 
ATOM   4943 O O   . PRO B 2 203 ? 114.387 143.567 68.841  1.00 20.28 ? 203 PRO B O   1 
ATOM   4944 C CB  . PRO B 2 203 ? 115.202 140.462 69.310  1.00 20.28 ? 203 PRO B CB  1 
ATOM   4945 C CG  . PRO B 2 203 ? 116.157 139.481 69.906  1.00 20.28 ? 203 PRO B CG  1 
ATOM   4946 C CD  . PRO B 2 203 ? 116.821 140.196 71.038  1.00 20.28 ? 203 PRO B CD  1 
ATOM   4947 N N   . GLU B 2 204 ? 114.563 143.150 71.050  1.00 20.67 ? 204 GLU B N   1 
ATOM   4948 C CA  . GLU B 2 204 ? 113.633 144.217 71.402  1.00 20.67 ? 204 GLU B CA  1 
ATOM   4949 C C   . GLU B 2 204 ? 114.193 145.583 71.025  1.00 20.67 ? 204 GLU B C   1 
ATOM   4950 O O   . GLU B 2 204 ? 113.460 146.452 70.539  1.00 20.67 ? 204 GLU B O   1 
ATOM   4951 C CB  . GLU B 2 204 ? 113.312 144.156 72.896  1.00 20.67 ? 204 GLU B CB  1 
ATOM   4952 C CG  . GLU B 2 204 ? 111.891 144.562 73.248  1.00 20.67 ? 204 GLU B CG  1 
ATOM   4953 C CD  . GLU B 2 204 ? 111.737 146.058 73.426  1.00 20.67 ? 204 GLU B CD  1 
ATOM   4954 O OE1 . GLU B 2 204 ? 112.731 146.720 73.791  1.00 20.67 ? 204 GLU B OE1 1 
ATOM   4955 O OE2 . GLU B 2 204 ? 110.622 146.573 73.202  1.00 20.67 ? 204 GLU B OE2 1 
ATOM   4956 N N   . ILE B 2 205 ? 115.489 145.790 71.237  1.00 20.77 ? 205 ILE B N   1 
ATOM   4957 C CA  . ILE B 2 205 ? 116.132 147.055 70.895  1.00 20.77 ? 205 ILE B CA  1 
ATOM   4958 C C   . ILE B 2 205 ? 116.375 147.091 69.392  1.00 20.77 ? 205 ILE B C   1 
ATOM   4959 O O   . ILE B 2 205 ? 117.049 146.215 68.840  1.00 20.77 ? 205 ILE B O   1 
ATOM   4960 C CB  . ILE B 2 205 ? 117.445 147.235 71.669  1.00 20.77 ? 205 ILE B CB  1 
ATOM   4961 C CG1 . ILE B 2 205 ? 117.173 147.283 73.174  1.00 20.77 ? 205 ILE B CG1 1 
ATOM   4962 C CG2 . ILE B 2 205 ? 118.165 148.490 71.208  1.00 20.77 ? 205 ILE B CG2 1 
ATOM   4963 C CD1 . ILE B 2 205 ? 116.064 148.234 73.565  1.00 20.77 ? 205 ILE B CD1 1 
ATOM   4964 N N   . ASN B 2 206 ? 115.835 148.111 68.730  1.00 19.95 ? 206 ASN B N   1 
ATOM   4965 C CA  . ASN B 2 206 ? 115.941 148.256 67.283  1.00 19.95 ? 206 ASN B CA  1 
ATOM   4966 C C   . ASN B 2 206 ? 117.006 149.249 66.852  1.00 19.95 ? 206 ASN B C   1 
ATOM   4967 O O   . ASN B 2 206 ? 117.840 148.920 66.006  1.00 19.95 ? 206 ASN B O   1 
ATOM   4968 C CB  . ASN B 2 206 ? 114.591 148.686 66.697  1.00 19.95 ? 206 ASN B CB  1 
ATOM   4969 C CG  . ASN B 2 206 ? 113.469 147.738 67.064  1.00 19.95 ? 206 ASN B CG  1 
ATOM   4970 O OD1 . ASN B 2 206 ? 112.553 148.098 67.803  1.00 19.95 ? 206 ASN B OD1 1 
ATOM   4971 N ND2 . ASN B 2 206 ? 113.533 146.516 66.547  1.00 19.95 ? 206 ASN B ND2 1 
ATOM   4972 N N   . THR B 2 207 ? 117.003 150.454 67.414  1.00 18.91 ? 207 THR B N   1 
ATOM   4973 C CA  . THR B 2 207 ? 117.960 151.491 67.063  1.00 18.91 ? 207 THR B CA  1 
ATOM   4974 C C   . THR B 2 207 ? 118.609 152.034 68.329  1.00 18.91 ? 207 THR B C   1 
ATOM   4975 O O   . THR B 2 207 ? 118.246 151.666 69.449  1.00 18.91 ? 207 THR B O   1 
ATOM   4976 C CB  . THR B 2 207 ? 117.296 152.632 66.281  1.00 18.91 ? 207 THR B CB  1 
ATOM   4977 O OG1 . THR B 2 207 ? 118.298 153.557 65.842  1.00 18.91 ? 207 THR B OG1 1 
ATOM   4978 C CG2 . THR B 2 207 ? 116.291 153.361 67.159  1.00 18.91 ? 207 THR B CG2 1 
ATOM   4979 N N   . LEU B 2 208 ? 119.585 152.924 68.134  1.00 18.62 ? 208 LEU B N   1 
ATOM   4980 C CA  . LEU B 2 208 ? 120.299 153.498 69.269  1.00 18.62 ? 208 LEU B CA  1 
ATOM   4981 C C   . LEU B 2 208 ? 119.375 154.319 70.158  1.00 18.62 ? 208 LEU B C   1 
ATOM   4982 O O   . LEU B 2 208 ? 119.559 154.352 71.379  1.00 18.62 ? 208 LEU B O   1 
ATOM   4983 C CB  . LEU B 2 208 ? 121.462 154.355 68.773  1.00 18.62 ? 208 LEU B CB  1 
ATOM   4984 C CG  . LEU B 2 208 ? 122.521 153.617 67.953  1.00 18.62 ? 208 LEU B CG  1 
ATOM   4985 C CD1 . LEU B 2 208 ? 123.468 154.599 67.291  1.00 18.62 ? 208 LEU B CD1 1 
ATOM   4986 C CD2 . LEU B 2 208 ? 123.287 152.645 68.830  1.00 18.62 ? 208 LEU B CD2 1 
ATOM   4987 N N   . ASP B 2 209 ? 118.374 154.980 69.569  1.00 18.65 ? 209 ASP B N   1 
ATOM   4988 C CA  . ASP B 2 209 ? 117.449 155.779 70.365  1.00 18.65 ? 209 ASP B CA  1 
ATOM   4989 C C   . ASP B 2 209 ? 116.759 154.942 71.433  1.00 18.65 ? 209 ASP B C   1 
ATOM   4990 O O   . ASP B 2 209 ? 116.415 155.460 72.502  1.00 18.65 ? 209 ASP B O   1 
ATOM   4991 C CB  . ASP B 2 209 ? 116.412 156.441 69.457  1.00 18.65 ? 209 ASP B CB  1 
ATOM   4992 N N   . ASP B 2 210 ? 116.567 153.646 71.170  1.00 18.94 ? 210 ASP B N   1 
ATOM   4993 C CA  . ASP B 2 210 ? 115.938 152.774 72.155  1.00 18.94 ? 210 ASP B CA  1 
ATOM   4994 C C   . ASP B 2 210 ? 116.744 152.706 73.444  1.00 18.94 ? 210 ASP B C   1 
ATOM   4995 O O   . ASP B 2 210 ? 116.166 152.581 74.530  1.00 18.94 ? 210 ASP B O   1 
ATOM   4996 C CB  . ASP B 2 210 ? 115.749 151.374 71.571  1.00 18.94 ? 210 ASP B CB  1 
ATOM   4997 N N   . ILE B 2 211 ? 118.068 152.791 73.356  1.00 18.95 ? 211 ILE B N   1 
ATOM   4998 C CA  . ILE B 2 211 ? 118.913 152.794 74.540  1.00 18.95 ? 211 ILE B CA  1 
ATOM   4999 C C   . ILE B 2 211 ? 119.301 154.217 74.944  1.00 18.95 ? 211 ILE B C   1 
ATOM   5000 O O   . ILE B 2 211 ? 120.258 154.409 75.692  1.00 18.95 ? 211 ILE B O   1 
ATOM   5001 C CB  . ILE B 2 211 ? 120.152 151.901 74.362  1.00 18.95 ? 211 ILE B CB  1 
ATOM   5002 C CG1 . ILE B 2 211 ? 121.040 152.405 73.226  1.00 18.95 ? 211 ILE B CG1 1 
ATOM   5003 C CG2 . ILE B 2 211 ? 119.735 150.466 74.098  1.00 18.95 ? 211 ILE B CG2 1 
ATOM   5004 C CD1 . ILE B 2 211 ? 122.375 151.699 73.140  1.00 18.95 ? 211 ILE B CD1 1 
ATOM   5005 N N   . ARG B 2 212 ? 118.567 155.220 74.462  1.00 21.60 ? 212 ARG B N   1 
ATOM   5006 C CA  . ARG B 2 212 ? 118.786 156.607 74.843  1.00 21.60 ? 212 ARG B CA  1 
ATOM   5007 C C   . ARG B 2 212 ? 117.693 157.160 75.746  1.00 21.60 ? 212 ARG B C   1 
ATOM   5008 O O   . ARG B 2 212 ? 117.821 158.291 76.226  1.00 21.60 ? 212 ARG B O   1 
ATOM   5009 C CB  . ARG B 2 212 ? 118.904 157.491 73.595  1.00 21.60 ? 212 ARG B CB  1 
ATOM   5010 C CG  . ARG B 2 212 ? 120.169 157.281 72.781  1.00 21.60 ? 212 ARG B CG  1 
ATOM   5011 C CD  . ARG B 2 212 ? 120.889 158.602 72.553  1.00 21.60 ? 212 ARG B CD  1 
ATOM   5012 N NE  . ARG B 2 212 ? 122.045 158.459 71.672  1.00 21.60 ? 212 ARG B NE  1 
ATOM   5013 C CZ  . ARG B 2 212 ? 121.999 158.593 70.351  1.00 21.60 ? 212 ARG B CZ  1 
ATOM   5014 N NH1 . ARG B 2 212 ? 120.852 158.876 69.751  1.00 21.60 ? 212 ARG B NH1 1 
ATOM   5015 N NH2 . ARG B 2 212 ? 123.102 158.446 69.630  1.00 21.60 ? 212 ARG B NH2 1 
ATOM   5016 N N   . LYS B 2 213 ? 116.624 156.401 75.991  1.00 23.28 ? 213 LYS B N   1 
ATOM   5017 C CA  . LYS B 2 213 ? 115.467 156.920 76.711  1.00 23.28 ? 213 LYS B CA  1 
ATOM   5018 C C   . LYS B 2 213 ? 114.959 156.031 77.837  1.00 23.28 ? 213 LYS B C   1 
ATOM   5019 O O   . LYS B 2 213 ? 114.232 156.536 78.701  1.00 23.28 ? 213 LYS B O   1 
ATOM   5020 C CB  . LYS B 2 213 ? 114.304 157.175 75.740  1.00 23.28 ? 213 LYS B CB  1 
ATOM   5021 C CG  . LYS B 2 213 ? 113.723 155.908 75.132  1.00 23.28 ? 213 LYS B CG  1 
ATOM   5022 C CD  . LYS B 2 213 ? 112.549 156.219 74.221  1.00 23.28 ? 213 LYS B CD  1 
ATOM   5023 C CE  . LYS B 2 213 ? 113.014 156.855 72.922  1.00 23.28 ? 213 LYS B CE  1 
ATOM   5024 N NZ  . LYS B 2 213 ? 113.833 155.915 72.109  1.00 23.28 ? 213 LYS B NZ  1 
ATOM   5025 N N   . LEU B 2 214 ? 115.301 154.746 77.864  1.00 21.94 ? 214 LEU B N   1 
ATOM   5026 C CA  . LEU B 2 214 ? 114.735 153.849 78.862  1.00 21.94 ? 214 LEU B CA  1 
ATOM   5027 C C   . LEU B 2 214 ? 115.212 154.223 80.262  1.00 21.94 ? 214 LEU B C   1 
ATOM   5028 O O   . LEU B 2 214 ? 116.305 154.764 80.451  1.00 21.94 ? 214 LEU B O   1 
ATOM   5029 C CB  . LEU B 2 214 ? 115.099 152.394 78.558  1.00 21.94 ? 214 LEU B CB  1 
ATOM   5030 C CG  . LEU B 2 214 ? 116.519 151.896 78.845  1.00 21.94 ? 214 LEU B CG  1 
ATOM   5031 C CD1 . LEU B 2 214 ? 116.545 150.378 78.860  1.00 21.94 ? 214 LEU B CD1 1 
ATOM   5032 C CD2 . LEU B 2 214 ? 117.514 152.425 77.830  1.00 21.94 ? 214 LEU B CD2 1 
ATOM   5033 N N   . ASP B 2 215 ? 114.368 153.933 81.250  1.00 22.45 ? 215 ASP B N   1 
ATOM   5034 C CA  . ASP B 2 215 ? 114.678 154.240 82.643  1.00 22.45 ? 215 ASP B CA  1 
ATOM   5035 C C   . ASP B 2 215 ? 115.739 153.273 83.152  1.00 22.45 ? 215 ASP B C   1 
ATOM   5036 O O   . ASP B 2 215 ? 115.510 152.061 83.209  1.00 22.45 ? 215 ASP B O   1 
ATOM   5037 C CB  . ASP B 2 215 ? 113.414 154.158 83.492  1.00 22.45 ? 215 ASP B CB  1 
ATOM   5038 C CG  . ASP B 2 215 ? 113.669 154.492 84.947  1.00 22.45 ? 215 ASP B CG  1 
ATOM   5039 O OD1 . ASP B 2 215 ? 113.809 155.691 85.265  1.00 22.45 ? 215 ASP B OD1 1 
ATOM   5040 O OD2 . ASP B 2 215 ? 113.733 153.556 85.771  1.00 22.45 ? 215 ASP B OD2 1 
ATOM   5041 N N   . ARG B 2 216 ? 116.902 153.805 83.522  1.00 20.96 ? 216 ARG B N   1 
ATOM   5042 C CA  . ARG B 2 216 ? 118.015 152.998 84.000  1.00 20.96 ? 216 ARG B CA  1 
ATOM   5043 C C   . ARG B 2 216 ? 118.200 153.079 85.509  1.00 20.96 ? 216 ARG B C   1 
ATOM   5044 O O   . ARG B 2 216 ? 119.166 152.517 86.033  1.00 20.96 ? 216 ARG B O   1 
ATOM   5045 C CB  . ARG B 2 216 ? 119.307 153.419 83.299  1.00 20.96 ? 216 ARG B CB  1 
ATOM   5046 N N   . PHE B 2 217 ? 117.301 153.756 86.220  1.00 17.73 ? 217 PHE B N   1 
ATOM   5047 C CA  . PHE B 2 217 ? 117.448 153.998 87.654  1.00 17.73 ? 217 PHE B CA  1 
ATOM   5048 C C   . PHE B 2 217 ? 116.626 153.026 88.486  1.00 17.73 ? 217 PHE B C   1 
ATOM   5049 O O   . PHE B 2 217 ? 116.087 153.396 89.532  1.00 17.73 ? 217 PHE B O   1 
ATOM   5050 C CB  . PHE B 2 217 ? 117.072 155.437 87.988  1.00 17.73 ? 217 PHE B CB  1 
ATOM   5051 C CG  . PHE B 2 217 ? 117.715 156.451 87.094  1.00 17.73 ? 217 PHE B CG  1 
ATOM   5052 C CD1 . PHE B 2 217 ? 116.983 157.509 86.588  1.00 17.73 ? 217 PHE B CD1 1 
ATOM   5053 C CD2 . PHE B 2 217 ? 119.054 156.349 86.761  1.00 17.73 ? 217 PHE B CD2 1 
ATOM   5054 C CE1 . PHE B 2 217 ? 117.571 158.445 85.764  1.00 17.73 ? 217 PHE B CE1 1 
ATOM   5055 C CE2 . PHE B 2 217 ? 119.648 157.281 85.937  1.00 17.73 ? 217 PHE B CE2 1 
ATOM   5056 C CZ  . PHE B 2 217 ? 118.906 158.331 85.438  1.00 17.73 ? 217 PHE B CZ  1 
ATOM   5057 N N   . LYS B 2 218 ? 116.512 151.775 88.049  1.00 18.96 ? 218 LYS B N   1 
ATOM   5058 C CA  . LYS B 2 218 ? 115.711 150.791 88.758  1.00 18.96 ? 218 LYS B CA  1 
ATOM   5059 C C   . LYS B 2 218 ? 116.416 149.443 88.739  1.00 18.96 ? 218 LYS B C   1 
ATOM   5060 O O   . LYS B 2 218 ? 117.300 149.189 87.918  1.00 18.96 ? 218 LYS B O   1 
ATOM   5061 C CB  . LYS B 2 218 ? 114.310 150.656 88.145  1.00 18.96 ? 218 LYS B CB  1 
ATOM   5062 C CG  . LYS B 2 218 ? 114.264 149.782 86.900  1.00 18.96 ? 218 LYS B CG  1 
ATOM   5063 C CD  . LYS B 2 218 ? 112.845 149.628 86.379  1.00 18.96 ? 218 LYS B CD  1 
ATOM   5064 C CE  . LYS B 2 218 ? 112.836 148.986 85.003  1.00 18.96 ? 218 LYS B CE  1 
ATOM   5065 N NZ  . LYS B 2 218 ? 113.918 149.527 84.137  1.00 18.96 ? 218 LYS B NZ  1 
ATOM   5066 N N   . GLU B 2 219 ? 116.013 148.586 89.669  1.00 17.48 ? 219 GLU B N   1 
ATOM   5067 C CA  . GLU B 2 219 ? 116.464 147.205 89.652  1.00 17.48 ? 219 GLU B CA  1 
ATOM   5068 C C   . GLU B 2 219 ? 115.971 146.527 88.376  1.00 17.48 ? 219 GLU B C   1 
ATOM   5069 O O   . GLU B 2 219 ? 114.820 146.732 87.972  1.00 17.48 ? 219 GLU B O   1 
ATOM   5070 C CB  . GLU B 2 219 ? 115.940 146.467 90.884  1.00 17.48 ? 219 GLU B CB  1 
ATOM   5071 C CG  . GLU B 2 219 ? 116.116 144.960 90.854  1.00 17.48 ? 219 GLU B CG  1 
ATOM   5072 C CD  . GLU B 2 219 ? 117.496 144.530 91.293  1.00 17.48 ? 219 GLU B CD  1 
ATOM   5073 O OE1 . GLU B 2 219 ? 118.213 145.358 91.890  1.00 17.48 ? 219 GLU B OE1 1 
ATOM   5074 O OE2 . GLU B 2 219 ? 117.862 143.364 91.042  1.00 17.48 ? 219 GLU B OE2 1 
ATOM   5075 N N   . PRO B 2 220 ? 116.808 145.737 87.708  1.00 19.43 ? 220 PRO B N   1 
ATOM   5076 C CA  . PRO B 2 220 ? 116.387 145.092 86.459  1.00 19.43 ? 220 PRO B CA  1 
ATOM   5077 C C   . PRO B 2 220 ? 115.197 144.179 86.687  1.00 19.43 ? 220 PRO B C   1 
ATOM   5078 O O   . PRO B 2 220 ? 115.107 143.504 87.723  1.00 19.43 ? 220 PRO B O   1 
ATOM   5079 C CB  . PRO B 2 220 ? 117.629 144.293 86.036  1.00 19.43 ? 220 PRO B CB  1 
ATOM   5080 C CG  . PRO B 2 220 ? 118.763 144.961 86.722  1.00 19.43 ? 220 PRO B CG  1 
ATOM   5081 C CD  . PRO B 2 220 ? 118.218 145.462 88.024  1.00 19.43 ? 220 PRO B CD  1 
ATOM   5082 N N   . PRO B 2 221 ? 114.258 144.134 85.743  1.00 20.71 ? 221 PRO B N   1 
ATOM   5083 C CA  . PRO B 2 221 ? 113.102 143.243 85.893  1.00 20.71 ? 221 PRO B CA  1 
ATOM   5084 C C   . PRO B 2 221 ? 113.424 141.814 85.491  1.00 20.71 ? 221 PRO B C   1 
ATOM   5085 O O   . PRO B 2 221 ? 114.579 141.489 85.199  1.00 20.71 ? 221 PRO B O   1 
ATOM   5086 C CB  . PRO B 2 221 ? 112.061 143.869 84.960  1.00 20.71 ? 221 PRO B CB  1 
ATOM   5087 C CG  . PRO B 2 221 ? 112.879 144.501 83.885  1.00 20.71 ? 221 PRO B CG  1 
ATOM   5088 C CD  . PRO B 2 221 ? 114.165 144.963 84.529  1.00 20.71 ? 221 PRO B CD  1 
ATOM   5089 N N   . ALA B 2 222 ? 112.409 140.948 85.483  1.00 21.11 ? 222 ALA B N   1 
ATOM   5090 C CA  . ALA B 2 222 ? 112.617 139.573 85.043  1.00 21.11 ? 222 ALA B CA  1 
ATOM   5091 C C   . ALA B 2 222 ? 112.978 139.505 83.566  1.00 21.11 ? 222 ALA B C   1 
ATOM   5092 O O   . ALA B 2 222 ? 113.774 138.649 83.163  1.00 21.11 ? 222 ALA B O   1 
ATOM   5093 C CB  . ALA B 2 222 ? 111.371 138.736 85.327  1.00 21.11 ? 222 ALA B CB  1 
ATOM   5094 N N   . TYR B 2 223 ? 112.406 140.385 82.748  1.00 23.05 ? 223 TYR B N   1 
ATOM   5095 C CA  . TYR B 2 223 ? 112.711 140.421 81.326  1.00 23.05 ? 223 TYR B CA  1 
ATOM   5096 C C   . TYR B 2 223 ? 112.449 141.828 80.814  1.00 23.05 ? 223 TYR B C   1 
ATOM   5097 O O   . TYR B 2 223 ? 111.744 142.618 81.448  1.00 23.05 ? 223 TYR B O   1 
ATOM   5098 C CB  . TYR B 2 223 ? 111.884 139.400 80.532  1.00 23.05 ? 223 TYR B CB  1 
ATOM   5099 C CG  . TYR B 2 223 ? 110.420 139.336 80.915  1.00 23.05 ? 223 TYR B CG  1 
ATOM   5100 C CD1 . TYR B 2 223 ? 109.999 138.636 82.039  1.00 23.05 ? 223 TYR B CD1 1 
ATOM   5101 C CD2 . TYR B 2 223 ? 109.457 139.981 80.149  1.00 23.05 ? 223 TYR B CD2 1 
ATOM   5102 C CE1 . TYR B 2 223 ? 108.663 138.581 82.387  1.00 23.05 ? 223 TYR B CE1 1 
ATOM   5103 C CE2 . TYR B 2 223 ? 108.120 139.930 80.489  1.00 23.05 ? 223 TYR B CE2 1 
ATOM   5104 C CZ  . TYR B 2 223 ? 107.729 139.229 81.609  1.00 23.05 ? 223 TYR B CZ  1 
ATOM   5105 O OH  . TYR B 2 223 ? 106.398 139.177 81.951  1.00 23.05 ? 223 TYR B OH  1 
ATOM   5106 N N   . GLY B 2 224 ? 113.027 142.131 79.655  1.00 21.93 ? 224 GLY B N   1 
ATOM   5107 C CA  . GLY B 2 224 ? 112.854 143.422 79.036  1.00 21.93 ? 224 GLY B CA  1 
ATOM   5108 C C   . GLY B 2 224 ? 114.100 143.884 78.310  1.00 21.93 ? 224 GLY B C   1 
ATOM   5109 O O   . GLY B 2 224 ? 115.017 143.102 78.044  1.00 21.93 ? 224 GLY B O   1 
ATOM   5110 N N   . PRO B 2 225 ? 114.151 145.171 77.966  1.00 23.22 ? 225 PRO B N   1 
ATOM   5111 C CA  . PRO B 2 225 ? 115.331 145.705 77.271  1.00 23.22 ? 225 PRO B CA  1 
ATOM   5112 C C   . PRO B 2 225 ? 116.570 145.722 78.152  1.00 23.22 ? 225 PRO B C   1 
ATOM   5113 O O   . PRO B 2 225 ? 117.632 145.229 77.759  1.00 23.22 ? 225 PRO B O   1 
ATOM   5114 C CB  . PRO B 2 225 ? 114.902 147.128 76.885  1.00 23.22 ? 225 PRO B CB  1 
ATOM   5115 C CG  . PRO B 2 225 ? 113.408 147.163 77.062  1.00 23.22 ? 225 PRO B CG  1 
ATOM   5116 C CD  . PRO B 2 225 ? 113.109 146.192 78.154  1.00 23.22 ? 225 PRO B CD  1 
ATOM   5117 N N   . MET B 2 226 ? 116.441 146.290 79.353  1.00 22.70 ? 226 MET B N   1 
ATOM   5118 C CA  . MET B 2 226 ? 117.590 146.391 80.245  1.00 22.70 ? 226 MET B CA  1 
ATOM   5119 C C   . MET B 2 226 ? 117.972 145.038 80.829  1.00 22.70 ? 226 MET B C   1 
ATOM   5120 O O   . MET B 2 226 ? 119.143 144.814 81.152  1.00 22.70 ? 226 MET B O   1 
ATOM   5121 C CB  . MET B 2 226 ? 117.305 147.401 81.357  1.00 22.70 ? 226 MET B CB  1 
ATOM   5122 C CG  . MET B 2 226 ? 116.294 146.939 82.389  1.00 22.70 ? 226 MET B CG  1 
ATOM   5123 S SD  . MET B 2 226 ? 116.307 147.955 83.878  1.00 22.70 ? 226 MET B SD  1 
ATOM   5124 C CE  . MET B 2 226 ? 118.046 147.917 84.299  1.00 22.70 ? 226 MET B CE  1 
ATOM   5125 N N   . CYS B 2 227 ? 117.010 144.127 80.974  1.00 21.82 ? 227 CYS B N   1 
ATOM   5126 C CA  . CYS B 2 227 ? 117.321 142.787 81.452  1.00 21.82 ? 227 CYS B CA  1 
ATOM   5127 C C   . CYS B 2 227 ? 117.945 141.917 80.372  1.00 21.82 ? 227 CYS B C   1 
ATOM   5128 O O   . CYS B 2 227 ? 118.561 140.895 80.693  1.00 21.82 ? 227 CYS B O   1 
ATOM   5129 C CB  . CYS B 2 227 ? 116.060 142.113 81.995  1.00 21.82 ? 227 CYS B CB  1 
ATOM   5130 S SG  . CYS B 2 227 ? 116.355 140.530 82.813  1.00 21.82 ? 227 CYS B SG  1 
ATOM   5131 N N   . ASP B 2 228 ? 117.802 142.296 79.104  1.00 20.79 ? 228 ASP B N   1 
ATOM   5132 C CA  . ASP B 2 228 ? 118.412 141.556 78.009  1.00 20.79 ? 228 ASP B CA  1 
ATOM   5133 C C   . ASP B 2 228 ? 119.734 142.151 77.548  1.00 20.79 ? 228 ASP B C   1 
ATOM   5134 O O   . ASP B 2 228 ? 120.572 141.419 77.013  1.00 20.79 ? 228 ASP B O   1 
ATOM   5135 C CB  . ASP B 2 228 ? 117.453 141.481 76.817  1.00 20.79 ? 228 ASP B CB  1 
ATOM   5136 N N   . ILE B 2 229 ? 119.942 143.456 77.736  1.00 15.93 ? 229 ILE B N   1 
ATOM   5137 C CA  . ILE B 2 229 ? 121.196 144.071 77.309  1.00 15.93 ? 229 ILE B CA  1 
ATOM   5138 C C   . ILE B 2 229 ? 122.356 143.585 78.172  1.00 15.93 ? 229 ILE B C   1 
ATOM   5139 O O   . ILE B 2 229 ? 123.472 143.391 77.678  1.00 15.93 ? 229 ILE B O   1 
ATOM   5140 C CB  . ILE B 2 229 ? 121.070 145.608 77.313  1.00 15.93 ? 229 ILE B CB  1 
ATOM   5141 C CG1 . ILE B 2 229 ? 122.308 146.256 76.695  1.00 15.93 ? 229 ILE B CG1 1 
ATOM   5142 C CG2 . ILE B 2 229 ? 120.842 146.142 78.714  1.00 15.93 ? 229 ILE B CG2 1 
ATOM   5143 C CD1 . ILE B 2 229 ? 122.138 147.731 76.417  1.00 15.93 ? 229 ILE B CD1 1 
ATOM   5144 N N   . LEU B 2 230 ? 122.114 143.370 79.465  1.00 15.18 ? 230 LEU B N   1 
ATOM   5145 C CA  . LEU B 2 230 ? 123.151 142.928 80.388  1.00 15.18 ? 230 LEU B CA  1 
ATOM   5146 C C   . LEU B 2 230 ? 123.270 141.414 80.490  1.00 15.18 ? 230 LEU B C   1 
ATOM   5147 O O   . LEU B 2 230 ? 124.197 140.927 81.144  1.00 15.18 ? 230 LEU B O   1 
ATOM   5148 C CB  . LEU B 2 230 ? 122.891 143.486 81.789  1.00 15.18 ? 230 LEU B CB  1 
ATOM   5149 C CG  . LEU B 2 230 ? 122.341 144.901 81.908  1.00 15.18 ? 230 LEU B CG  1 
ATOM   5150 C CD1 . LEU B 2 230 ? 121.959 145.175 83.348  1.00 15.18 ? 230 LEU B CD1 1 
ATOM   5151 C CD2 . LEU B 2 230 ? 123.363 145.907 81.420  1.00 15.18 ? 230 LEU B CD2 1 
ATOM   5152 N N   . TRP B 2 231 ? 122.360 140.658 79.880  1.00 16.69 ? 231 TRP B N   1 
ATOM   5153 C CA  . TRP B 2 231 ? 122.372 139.210 80.002  1.00 16.69 ? 231 TRP B CA  1 
ATOM   5154 C C   . TRP B 2 231 ? 122.503 138.478 78.675  1.00 16.69 ? 231 TRP B C   1 
ATOM   5155 O O   . TRP B 2 231 ? 122.695 137.258 78.685  1.00 16.69 ? 231 TRP B O   1 
ATOM   5156 C CB  . TRP B 2 231 ? 121.100 138.722 80.710  1.00 16.69 ? 231 TRP B CB  1 
ATOM   5157 C CG  . TRP B 2 231 ? 121.100 138.927 82.192  1.00 16.69 ? 231 TRP B CG  1 
ATOM   5158 C CD1 . TRP B 2 231 ? 120.562 139.978 82.870  1.00 16.69 ? 231 TRP B CD1 1 
ATOM   5159 C CD2 . TRP B 2 231 ? 121.646 138.049 83.182  1.00 16.69 ? 231 TRP B CD2 1 
ATOM   5160 N NE1 . TRP B 2 231 ? 120.746 139.816 84.220  1.00 16.69 ? 231 TRP B NE1 1 
ATOM   5161 C CE2 . TRP B 2 231 ? 121.410 138.638 84.438  1.00 16.69 ? 231 TRP B CE2 1 
ATOM   5162 C CE3 . TRP B 2 231 ? 122.315 136.823 83.129  1.00 16.69 ? 231 TRP B CE3 1 
ATOM   5163 C CZ2 . TRP B 2 231 ? 121.819 138.046 85.629  1.00 16.69 ? 231 TRP B CZ2 1 
ATOM   5164 C CZ3 . TRP B 2 231 ? 122.721 136.237 84.313  1.00 16.69 ? 231 TRP B CZ3 1 
ATOM   5165 C CH2 . TRP B 2 231 ? 122.471 136.849 85.546  1.00 16.69 ? 231 TRP B CH2 1 
ATOM   5166 N N   . SER B 2 232 ? 122.409 139.173 77.545  1.00 19.09 ? 232 SER B N   1 
ATOM   5167 C CA  . SER B 2 232 ? 122.507 138.514 76.253  1.00 19.09 ? 232 SER B CA  1 
ATOM   5168 C C   . SER B 2 232 ? 123.901 137.920 76.058  1.00 19.09 ? 232 SER B C   1 
ATOM   5169 O O   . SER B 2 232 ? 124.825 138.149 76.840  1.00 19.09 ? 232 SER B O   1 
ATOM   5170 C CB  . SER B 2 232 ? 122.188 139.491 75.125  1.00 19.09 ? 232 SER B CB  1 
ATOM   5171 O OG  . SER B 2 232 ? 122.620 138.979 73.879  1.00 19.09 ? 232 SER B OG  1 
ATOM   5172 N N   . ASP B 2 233 ? 124.042 137.146 74.987  1.00 19.52 ? 233 ASP B N   1 
ATOM   5173 C CA  . ASP B 2 233 ? 125.281 136.426 74.734  1.00 19.52 ? 233 ASP B CA  1 
ATOM   5174 C C   . ASP B 2 233 ? 125.321 135.979 73.277  1.00 19.52 ? 233 ASP B C   1 
ATOM   5175 O O   . ASP B 2 233 ? 124.339 135.418 72.775  1.00 19.52 ? 233 ASP B O   1 
ATOM   5176 C CB  . ASP B 2 233 ? 125.390 135.222 75.673  1.00 19.52 ? 233 ASP B CB  1 
ATOM   5177 C CG  . ASP B 2 233 ? 126.820 134.910 76.070  1.00 19.52 ? 233 ASP B CG  1 
ATOM   5178 O OD1 . ASP B 2 233 ? 127.738 135.637 75.646  1.00 19.52 ? 233 ASP B OD1 1 
ATOM   5179 O OD2 . ASP B 2 233 ? 127.026 133.931 76.817  1.00 19.52 ? 233 ASP B OD2 1 
ATOM   5180 N N   . PRO B 2 234 ? 126.420 136.214 72.566  1.00 19.60 ? 234 PRO B N   1 
ATOM   5181 C CA  . PRO B 2 234 ? 126.523 135.728 71.186  1.00 19.60 ? 234 PRO B CA  1 
ATOM   5182 C C   . PRO B 2 234 ? 126.576 134.209 71.131  1.00 19.60 ? 234 PRO B C   1 
ATOM   5183 O O   . PRO B 2 234 ? 126.851 133.527 72.121  1.00 19.60 ? 234 PRO B O   1 
ATOM   5184 C CB  . PRO B 2 234 ? 127.831 136.343 70.675  1.00 19.60 ? 234 PRO B CB  1 
ATOM   5185 C CG  . PRO B 2 234 ? 128.556 136.819 71.875  1.00 19.60 ? 234 PRO B CG  1 
ATOM   5186 C CD  . PRO B 2 234 ? 127.557 137.061 72.953  1.00 19.60 ? 234 PRO B CD  1 
ATOM   5187 N N   . LEU B 2 235 ? 126.290 133.683 69.941  1.00 21.90 ? 235 LEU B N   1 
ATOM   5188 C CA  . LEU B 2 235 ? 126.296 132.241 69.735  1.00 21.90 ? 235 LEU B CA  1 
ATOM   5189 C C   . LEU B 2 235 ? 127.685 131.674 70.007  1.00 21.90 ? 235 LEU B C   1 
ATOM   5190 O O   . LEU B 2 235 ? 128.693 132.194 69.522  1.00 21.90 ? 235 LEU B O   1 
ATOM   5191 C CB  . LEU B 2 235 ? 125.862 131.916 68.305  1.00 21.90 ? 235 LEU B CB  1 
ATOM   5192 C CG  . LEU B 2 235 ? 125.734 130.440 67.940  1.00 21.90 ? 235 LEU B CG  1 
ATOM   5193 C CD1 . LEU B 2 235 ? 124.643 129.804 68.786  1.00 21.90 ? 235 LEU B CD1 1 
ATOM   5194 C CD2 . LEU B 2 235 ? 125.443 130.272 66.460  1.00 21.90 ? 235 LEU B CD2 1 
ATOM   5195 N N   . GLU B 2 236 ? 127.734 130.598 70.788  1.00 25.28 ? 236 GLU B N   1 
ATOM   5196 C CA  . GLU B 2 236 ? 128.995 130.061 71.284  1.00 25.28 ? 236 GLU B CA  1 
ATOM   5197 C C   . GLU B 2 236 ? 129.587 128.974 70.396  1.00 25.28 ? 236 GLU B C   1 
ATOM   5198 O O   . GLU B 2 236 ? 130.713 128.534 70.653  1.00 25.28 ? 236 GLU B O   1 
ATOM   5199 C CB  . GLU B 2 236 ? 128.809 129.512 72.702  1.00 25.28 ? 236 GLU B CB  1 
ATOM   5200 C CG  . GLU B 2 236 ? 127.972 128.242 72.778  1.00 25.28 ? 236 GLU B CG  1 
ATOM   5201 C CD  . GLU B 2 236 ? 126.483 128.509 72.679  1.00 25.28 ? 236 GLU B CD  1 
ATOM   5202 O OE1 . GLU B 2 236 ? 126.083 129.692 72.703  1.00 25.28 ? 236 GLU B OE1 1 
ATOM   5203 O OE2 . GLU B 2 236 ? 125.711 127.532 72.579  1.00 25.28 ? 236 GLU B OE2 1 
ATOM   5204 N N   . ASP B 2 237 ? 128.872 128.533 69.367  1.00 25.02 ? 237 ASP B N   1 
ATOM   5205 C CA  . ASP B 2 237 ? 129.329 127.465 68.480  1.00 25.02 ? 237 ASP B CA  1 
ATOM   5206 C C   . ASP B 2 237 ? 129.125 127.865 67.025  1.00 25.02 ? 237 ASP B C   1 
ATOM   5207 O O   . ASP B 2 237 ? 128.569 127.118 66.218  1.00 25.02 ? 237 ASP B O   1 
ATOM   5208 C CB  . ASP B 2 237 ? 128.628 126.146 68.796  1.00 25.02 ? 237 ASP B CB  1 
ATOM   5209 C CG  . ASP B 2 237 ? 127.125 126.288 68.869  1.00 25.02 ? 237 ASP B CG  1 
ATOM   5210 O OD1 . ASP B 2 237 ? 126.647 127.431 69.001  1.00 25.02 ? 237 ASP B OD1 1 
ATOM   5211 O OD2 . ASP B 2 237 ? 126.421 125.259 68.796  1.00 25.02 ? 237 ASP B OD2 1 
ATOM   5212 N N   . PHE B 2 238 ? 129.567 129.075 66.686  1.00 26.85 ? 238 PHE B N   1 
ATOM   5213 C CA  . PHE B 2 238 ? 129.455 129.568 65.319  1.00 26.85 ? 238 PHE B CA  1 
ATOM   5214 C C   . PHE B 2 238 ? 130.145 128.620 64.346  1.00 26.85 ? 238 PHE B C   1 
ATOM   5215 O O   . PHE B 2 238 ? 131.214 128.074 64.635  1.00 26.85 ? 238 PHE B O   1 
ATOM   5216 C CB  . PHE B 2 238 ? 130.072 130.963 65.209  1.00 26.85 ? 238 PHE B CB  1 
ATOM   5217 C CG  . PHE B 2 238 ? 129.077 132.081 65.326  1.00 26.85 ? 238 PHE B CG  1 
ATOM   5218 C CD1 . PHE B 2 238 ? 128.143 132.301 64.329  1.00 26.85 ? 238 PHE B CD1 1 
ATOM   5219 C CD2 . PHE B 2 238 ? 129.085 132.920 66.428  1.00 26.85 ? 238 PHE B CD2 1 
ATOM   5220 C CE1 . PHE B 2 238 ? 127.229 133.332 64.432  1.00 26.85 ? 238 PHE B CE1 1 
ATOM   5221 C CE2 . PHE B 2 238 ? 128.175 133.954 66.536  1.00 26.85 ? 238 PHE B CE2 1 
ATOM   5222 C CZ  . PHE B 2 238 ? 127.245 134.160 65.537  1.00 26.85 ? 238 PHE B CZ  1 
ATOM   5223 N N   . GLY B 2 239 ? 129.524 128.425 63.188  1.00 24.61 ? 239 GLY B N   1 
ATOM   5224 C CA  . GLY B 2 239 ? 130.040 127.523 62.182  1.00 24.61 ? 239 GLY B CA  1 
ATOM   5225 C C   . GLY B 2 239 ? 129.391 126.158 62.135  1.00 24.61 ? 239 GLY B C   1 
ATOM   5226 O O   . GLY B 2 239 ? 129.878 125.288 61.403  1.00 24.61 ? 239 GLY B O   1 
ATOM   5227 N N   . ASN B 2 240 ? 128.318 125.939 62.888  1.00 26.51 ? 240 ASN B N   1 
ATOM   5228 C CA  . ASN B 2 240 ? 127.625 124.656 62.885  1.00 26.51 ? 240 ASN B CA  1 
ATOM   5229 C C   . ASN B 2 240 ? 126.938 124.403 61.546  1.00 26.51 ? 240 ASN B C   1 
ATOM   5230 O O   . ASN B 2 240 ? 126.650 125.338 60.798  1.00 26.51 ? 240 ASN B O   1 
ATOM   5231 C CB  . ASN B 2 240 ? 126.601 124.596 64.021  1.00 26.51 ? 240 ASN B CB  1 
ATOM   5232 C CG  . ASN B 2 240 ? 125.675 125.799 64.037  1.00 26.51 ? 240 ASN B CG  1 
ATOM   5233 O OD1 . ASN B 2 240 ? 125.828 126.727 63.242  1.00 26.51 ? 240 ASN B OD1 1 
ATOM   5234 N ND2 . ASN B 2 240 ? 124.709 125.788 64.948  1.00 26.51 ? 240 ASN B ND2 1 
ATOM   5235 N N   . HIS B 2 246 ? 118.570 134.597 66.262  1.00 25.37 ? 246 HIS B N   1 
ATOM   5236 C CA  . HIS B 2 246 ? 118.062 135.959 66.346  1.00 25.37 ? 246 HIS B CA  1 
ATOM   5237 C C   . HIS B 2 246 ? 117.512 136.251 67.736  1.00 25.37 ? 246 HIS B C   1 
ATOM   5238 O O   . HIS B 2 246 ? 117.913 137.219 68.380  1.00 25.37 ? 246 HIS B O   1 
ATOM   5239 C CB  . HIS B 2 246 ? 116.982 136.193 65.291  1.00 25.37 ? 246 HIS B CB  1 
ATOM   5240 C CG  . HIS B 2 246 ? 117.485 136.863 64.051  1.00 25.37 ? 246 HIS B CG  1 
ATOM   5241 N ND1 . HIS B 2 246 ? 117.624 138.230 63.950  1.00 25.37 ? 246 HIS B ND1 1 
ATOM   5242 C CD2 . HIS B 2 246 ? 117.886 136.354 62.862  1.00 25.37 ? 246 HIS B CD2 1 
ATOM   5243 C CE1 . HIS B 2 246 ? 118.087 138.536 62.751  1.00 25.37 ? 246 HIS B CE1 1 
ATOM   5244 N NE2 . HIS B 2 246 ? 118.254 137.416 62.071  1.00 25.37 ? 246 HIS B NE2 1 
ATOM   5245 N N   . PHE B 2 247 ? 116.585 135.406 68.191  1.00 21.86 ? 247 PHE B N   1 
ATOM   5246 C CA  . PHE B 2 247 ? 115.987 135.565 69.511  1.00 21.86 ? 247 PHE B CA  1 
ATOM   5247 C C   . PHE B 2 247 ? 115.829 134.224 70.219  1.00 21.86 ? 247 PHE B C   1 
ATOM   5248 O O   . PHE B 2 247 ? 114.922 134.057 71.042  1.00 21.86 ? 247 PHE B O   1 
ATOM   5249 C CB  . PHE B 2 247 ? 114.629 136.264 69.419  1.00 21.86 ? 247 PHE B CB  1 
ATOM   5250 N N   . THR B 2 248 ? 116.694 133.262 69.912  1.00 19.60 ? 248 THR B N   1 
ATOM   5251 C CA  . THR B 2 248 ? 116.615 131.956 70.551  1.00 19.60 ? 248 THR B CA  1 
ATOM   5252 C C   . THR B 2 248 ? 117.015 132.053 72.018  1.00 19.60 ? 248 THR B C   1 
ATOM   5253 O O   . THR B 2 248 ? 117.929 132.797 72.383  1.00 19.60 ? 248 THR B O   1 
ATOM   5254 C CB  . THR B 2 248 ? 117.505 130.951 69.826  1.00 19.60 ? 248 THR B CB  1 
ATOM   5255 O OG1 . THR B 2 248 ? 118.874 131.339 69.964  1.00 19.60 ? 248 THR B OG1 1 
ATOM   5256 C CG2 . THR B 2 248 ? 117.144 130.892 68.346  1.00 19.60 ? 248 THR B CG2 1 
ATOM   5257 N N   . HIS B 2 249 ? 116.324 131.288 72.858  1.00 17.74 ? 249 HIS B N   1 
ATOM   5258 C CA  . HIS B 2 249 ? 116.461 131.417 74.302  1.00 17.74 ? 249 HIS B CA  1 
ATOM   5259 C C   . HIS B 2 249 ? 117.819 130.910 74.783  1.00 17.74 ? 249 HIS B C   1 
ATOM   5260 O O   . HIS B 2 249 ? 118.494 130.125 74.112  1.00 17.74 ? 249 HIS B O   1 
ATOM   5261 C CB  . HIS B 2 249 ? 115.333 130.662 75.005  1.00 17.74 ? 249 HIS B CB  1 
ATOM   5262 C CG  . HIS B 2 249 ? 115.184 131.001 76.455  1.00 17.74 ? 249 HIS B CG  1 
ATOM   5263 N ND1 . HIS B 2 249 ? 115.916 130.379 77.443  1.00 17.74 ? 249 HIS B ND1 1 
ATOM   5264 C CD2 . HIS B 2 249 ? 114.401 131.909 77.084  1.00 17.74 ? 249 HIS B CD2 1 
ATOM   5265 C CE1 . HIS B 2 249 ? 115.583 130.881 78.618  1.00 17.74 ? 249 HIS B CE1 1 
ATOM   5266 N NE2 . HIS B 2 249 ? 114.664 131.810 78.428  1.00 17.74 ? 249 HIS B NE2 1 
ATOM   5267 N N   . ASN B 2 250 ? 118.212 131.377 75.966  1.00 18.81 ? 250 ASN B N   1 
ATOM   5268 C CA  . ASN B 2 250 ? 119.500 131.063 76.573  1.00 18.81 ? 250 ASN B CA  1 
ATOM   5269 C C   . ASN B 2 250 ? 119.357 129.893 77.537  1.00 18.81 ? 250 ASN B C   1 
ATOM   5270 O O   . ASN B 2 250 ? 118.537 129.938 78.460  1.00 18.81 ? 250 ASN B O   1 
ATOM   5271 C CB  . ASN B 2 250 ? 120.054 132.286 77.305  1.00 18.81 ? 250 ASN B CB  1 
ATOM   5272 C CG  . ASN B 2 250 ? 121.546 132.445 77.136  1.00 18.81 ? 250 ASN B CG  1 
ATOM   5273 O OD1 . ASN B 2 250 ? 122.154 131.831 76.270  1.00 18.81 ? 250 ASN B OD1 1 
ATOM   5274 N ND2 . ASN B 2 250 ? 122.140 133.303 77.951  1.00 18.81 ? 250 ASN B ND2 1 
ATOM   5275 N N   . THR B 2 251 ? 120.158 128.850 77.322  1.00 18.22 ? 251 THR B N   1 
ATOM   5276 C CA  . THR B 2 251 ? 120.235 127.758 78.283  1.00 18.22 ? 251 THR B CA  1 
ATOM   5277 C C   . THR B 2 251 ? 121.326 127.989 79.322  1.00 18.22 ? 251 THR B C   1 
ATOM   5278 O O   . THR B 2 251 ? 121.216 127.493 80.449  1.00 18.22 ? 251 THR B O   1 
ATOM   5279 C CB  . THR B 2 251 ? 120.474 126.433 77.557  1.00 18.22 ? 251 THR B CB  1 
ATOM   5280 O OG1 . THR B 2 251 ? 121.862 126.313 77.223  1.00 18.22 ? 251 THR B OG1 1 
ATOM   5281 C CG2 . THR B 2 251 ? 119.642 126.365 76.286  1.00 18.22 ? 251 THR B CG2 1 
ATOM   5282 N N   . VAL B 2 252 ? 122.377 128.732 78.964  1.00 18.39 ? 252 VAL B N   1 
ATOM   5283 C CA  . VAL B 2 252 ? 123.482 128.966 79.891  1.00 18.39 ? 252 VAL B CA  1 
ATOM   5284 C C   . VAL B 2 252 ? 123.024 129.819 81.067  1.00 18.39 ? 252 VAL B C   1 
ATOM   5285 O O   . VAL B 2 252 ? 123.285 129.493 82.231  1.00 18.39 ? 252 VAL B O   1 
ATOM   5286 C CB  . VAL B 2 252 ? 124.669 129.613 79.157  1.00 18.39 ? 252 VAL B CB  1 
ATOM   5287 C CG1 . VAL B 2 252 ? 125.921 129.560 80.020  1.00 18.39 ? 252 VAL B CG1 1 
ATOM   5288 C CG2 . VAL B 2 252 ? 124.907 128.926 77.824  1.00 18.39 ? 252 VAL B CG2 1 
ATOM   5289 N N   . ARG B 2 253 ? 122.336 130.923 80.783  1.00 18.45 ? 253 ARG B N   1 
ATOM   5290 C CA  . ARG B 2 253 ? 121.837 131.820 81.819  1.00 18.45 ? 253 ARG B CA  1 
ATOM   5291 C C   . ARG B 2 253 ? 120.366 131.579 82.131  1.00 18.45 ? 253 ARG B C   1 
ATOM   5292 O O   . ARG B 2 253 ? 119.986 131.490 83.302  1.00 18.45 ? 253 ARG B O   1 
ATOM   5293 C CB  . ARG B 2 253 ? 122.049 133.281 81.402  1.00 18.45 ? 253 ARG B CB  1 
ATOM   5294 C CG  . ARG B 2 253 ? 123.419 133.574 80.811  1.00 18.45 ? 253 ARG B CG  1 
ATOM   5295 C CD  . ARG B 2 253 ? 124.363 134.190 81.824  1.00 18.45 ? 253 ARG B CD  1 
ATOM   5296 N NE  . ARG B 2 253 ? 125.568 134.700 81.180  1.00 18.45 ? 253 ARG B NE  1 
ATOM   5297 C CZ  . ARG B 2 253 ? 126.681 133.994 81.016  1.00 18.45 ? 253 ARG B CZ  1 
ATOM   5298 N NH1 . ARG B 2 253 ? 126.745 132.747 81.457  1.00 18.45 ? 253 ARG B NH1 1 
ATOM   5299 N NH2 . ARG B 2 253 ? 127.730 134.533 80.414  1.00 18.45 ? 253 ARG B NH2 1 
ATOM   5300 N N   . GLY B 2 254 ? 119.531 131.467 81.103  1.00 17.05 ? 254 GLY B N   1 
ATOM   5301 C CA  . GLY B 2 254 ? 118.112 131.263 81.300  1.00 17.05 ? 254 GLY B CA  1 
ATOM   5302 C C   . GLY B 2 254 ? 117.297 132.521 81.476  1.00 17.05 ? 254 GLY B C   1 
ATOM   5303 O O   . GLY B 2 254 ? 116.198 132.452 82.039  1.00 17.05 ? 254 GLY B O   1 
ATOM   5304 N N   . CYS B 2 255 ? 117.794 133.673 81.022  1.00 19.85 ? 255 CYS B N   1 
ATOM   5305 C CA  . CYS B 2 255 ? 117.081 134.924 81.233  1.00 19.85 ? 255 CYS B CA  1 
ATOM   5306 C C   . CYS B 2 255 ? 117.031 135.835 80.011  1.00 19.85 ? 255 CYS B C   1 
ATOM   5307 O O   . CYS B 2 255 ? 116.262 136.801 80.025  1.00 19.85 ? 255 CYS B O   1 
ATOM   5308 C CB  . CYS B 2 255 ? 117.705 135.686 82.414  1.00 19.85 ? 255 CYS B CB  1 
ATOM   5309 S SG  . CYS B 2 255 ? 116.693 137.027 83.077  1.00 19.85 ? 255 CYS B SG  1 
ATOM   5310 N N   . SER B 2 256 ? 117.797 135.565 78.961  1.00 19.06 ? 256 SER B N   1 
ATOM   5311 C CA  . SER B 2 256 ? 117.804 136.431 77.784  1.00 19.06 ? 256 SER B CA  1 
ATOM   5312 C C   . SER B 2 256 ? 118.027 135.565 76.548  1.00 19.06 ? 256 SER B C   1 
ATOM   5313 O O   . SER B 2 256 ? 117.913 134.338 76.609  1.00 19.06 ? 256 SER B O   1 
ATOM   5314 C CB  . SER B 2 256 ? 118.848 137.548 77.944  1.00 19.06 ? 256 SER B CB  1 
ATOM   5315 O OG  . SER B 2 256 ? 118.502 138.410 79.014  1.00 19.06 ? 256 SER B OG  1 
ATOM   5316 N N   . TYR B 2 257 ? 118.327 136.201 75.422  1.00 19.13 ? 257 TYR B N   1 
ATOM   5317 C CA  . TYR B 2 257 ? 118.322 135.554 74.116  1.00 19.13 ? 257 TYR B CA  1 
ATOM   5318 C C   . TYR B 2 257 ? 119.734 135.514 73.535  1.00 19.13 ? 257 TYR B C   1 
ATOM   5319 O O   . TYR B 2 257 ? 120.710 135.897 74.182  1.00 19.13 ? 257 TYR B O   1 
ATOM   5320 C CB  . TYR B 2 257 ? 117.372 136.284 73.160  1.00 19.13 ? 257 TYR B CB  1 
ATOM   5321 C CG  . TYR B 2 257 ? 116.030 136.656 73.760  1.00 19.13 ? 257 TYR B CG  1 
ATOM   5322 C CD1 . TYR B 2 257 ? 115.379 135.811 74.648  1.00 19.13 ? 257 TYR B CD1 1 
ATOM   5323 C CD2 . TYR B 2 257 ? 115.423 137.865 73.447  1.00 19.13 ? 257 TYR B CD2 1 
ATOM   5324 C CE1 . TYR B 2 257 ? 114.159 136.155 75.199  1.00 19.13 ? 257 TYR B CE1 1 
ATOM   5325 C CE2 . TYR B 2 257 ? 114.203 138.217 73.994  1.00 19.13 ? 257 TYR B CE2 1 
ATOM   5326 C CZ  . TYR B 2 257 ? 113.577 137.358 74.868  1.00 19.13 ? 257 TYR B CZ  1 
ATOM   5327 O OH  . TYR B 2 257 ? 112.363 137.703 75.415  1.00 19.13 ? 257 TYR B OH  1 
ATOM   5328 N N   . PHE B 2 258 ? 119.827 135.028 72.299  1.00 21.04 ? 258 PHE B N   1 
ATOM   5329 C CA  . PHE B 2 258 ? 121.014 135.162 71.470  1.00 21.04 ? 258 PHE B CA  1 
ATOM   5330 C C   . PHE B 2 258 ? 120.873 136.331 70.503  1.00 21.04 ? 258 PHE B C   1 
ATOM   5331 O O   . PHE B 2 258 ? 119.896 137.084 70.510  1.00 21.04 ? 258 PHE B O   1 
ATOM   5332 C CB  . PHE B 2 258 ? 121.293 133.896 70.654  1.00 21.04 ? 258 PHE B CB  1 
ATOM   5333 C CG  . PHE B 2 258 ? 121.729 132.711 71.456  1.00 21.04 ? 258 PHE B CG  1 
ATOM   5334 C CD1 . PHE B 2 258 ? 122.156 132.847 72.761  1.00 21.04 ? 258 PHE B CD1 1 
ATOM   5335 C CD2 . PHE B 2 258 ? 121.741 131.452 70.881  1.00 21.04 ? 258 PHE B CD2 1 
ATOM   5336 C CE1 . PHE B 2 258 ? 122.576 131.747 73.473  1.00 21.04 ? 258 PHE B CE1 1 
ATOM   5337 C CE2 . PHE B 2 258 ? 122.145 130.348 71.596  1.00 21.04 ? 258 PHE B CE2 1 
ATOM   5338 C CZ  . PHE B 2 258 ? 122.565 130.497 72.897  1.00 21.04 ? 258 PHE B CZ  1 
ATOM   5339 N N   . TYR B 2 259 ? 121.888 136.470 69.656  1.00 22.78 ? 259 TYR B N   1 
ATOM   5340 C CA  . TYR B 2 259 ? 121.835 137.289 68.458  1.00 22.78 ? 259 TYR B CA  1 
ATOM   5341 C C   . TYR B 2 259 ? 122.833 136.696 67.475  1.00 22.78 ? 259 TYR B C   1 
ATOM   5342 O O   . TYR B 2 259 ? 123.914 136.252 67.871  1.00 22.78 ? 259 TYR B O   1 
ATOM   5343 C CB  . TYR B 2 259 ? 122.121 138.768 68.759  1.00 22.78 ? 259 TYR B CB  1 
ATOM   5344 C CG  . TYR B 2 259 ? 123.406 139.048 69.513  1.00 22.78 ? 259 TYR B CG  1 
ATOM   5345 C CD1 . TYR B 2 259 ? 123.371 139.477 70.833  1.00 22.78 ? 259 TYR B CD1 1 
ATOM   5346 C CD2 . TYR B 2 259 ? 124.644 138.930 68.899  1.00 22.78 ? 259 TYR B CD2 1 
ATOM   5347 C CE1 . TYR B 2 259 ? 124.532 139.744 71.527  1.00 22.78 ? 259 TYR B CE1 1 
ATOM   5348 C CE2 . TYR B 2 259 ? 125.809 139.195 69.584  1.00 22.78 ? 259 TYR B CE2 1 
ATOM   5349 C CZ  . TYR B 2 259 ? 125.747 139.603 70.897  1.00 22.78 ? 259 TYR B CZ  1 
ATOM   5350 O OH  . TYR B 2 259 ? 126.905 139.874 71.584  1.00 22.78 ? 259 TYR B OH  1 
ATOM   5351 N N   . SER B 2 260 ? 122.453 136.654 66.205  1.00 22.81 ? 260 SER B N   1 
ATOM   5352 C CA  . SER B 2 260 ? 123.251 136.003 65.180  1.00 22.81 ? 260 SER B CA  1 
ATOM   5353 C C   . SER B 2 260 ? 123.994 137.042 64.352  1.00 22.81 ? 260 SER B C   1 
ATOM   5354 O O   . SER B 2 260 ? 123.757 138.249 64.461  1.00 22.81 ? 260 SER B O   1 
ATOM   5355 C CB  . SER B 2 260 ? 122.369 135.130 64.282  1.00 22.81 ? 260 SER B CB  1 
ATOM   5356 O OG  . SER B 2 260 ? 121.441 135.921 63.562  1.00 22.81 ? 260 SER B OG  1 
ATOM   5357 N N   . TYR B 2 261 ? 124.913 136.550 63.524  1.00 24.02 ? 261 TYR B N   1 
ATOM   5358 C CA  . TYR B 2 261 ? 125.650 137.440 62.631  1.00 24.02 ? 261 TYR B CA  1 
ATOM   5359 C C   . TYR B 2 261 ? 124.736 138.266 61.734  1.00 24.02 ? 261 TYR B C   1 
ATOM   5360 O O   . TYR B 2 261 ? 125.017 139.464 61.554  1.00 24.02 ? 261 TYR B O   1 
ATOM   5361 C CB  . TYR B 2 261 ? 126.654 136.630 61.802  1.00 24.02 ? 261 TYR B CB  1 
ATOM   5362 C CG  . TYR B 2 261 ? 127.497 137.472 60.876  1.00 24.02 ? 261 TYR B CG  1 
ATOM   5363 C CD1 . TYR B 2 261 ? 128.547 138.235 61.366  1.00 24.02 ? 261 TYR B CD1 1 
ATOM   5364 C CD2 . TYR B 2 261 ? 127.243 137.507 59.512  1.00 24.02 ? 261 TYR B CD2 1 
ATOM   5365 C CE1 . TYR B 2 261 ? 129.322 139.007 60.524  1.00 24.02 ? 261 TYR B CE1 1 
ATOM   5366 C CE2 . TYR B 2 261 ? 128.012 138.277 58.662  1.00 24.02 ? 261 TYR B CE2 1 
ATOM   5367 C CZ  . TYR B 2 261 ? 129.051 139.025 59.174  1.00 24.02 ? 261 TYR B CZ  1 
ATOM   5368 O OH  . TYR B 2 261 ? 129.821 139.794 58.332  1.00 24.02 ? 261 TYR B OH  1 
ATOM   5369 N N   . PRO B 2 262 ? 123.666 137.720 61.138  1.00 22.26 ? 262 PRO B N   1 
ATOM   5370 C CA  . PRO B 2 262 ? 122.716 138.602 60.442  1.00 22.26 ? 262 PRO B CA  1 
ATOM   5371 C C   . PRO B 2 262 ? 122.114 139.666 61.342  1.00 22.26 ? 262 PRO B C   1 
ATOM   5372 O O   . PRO B 2 262 ? 121.882 140.790 60.885  1.00 22.26 ? 262 PRO B O   1 
ATOM   5373 C CB  . PRO B 2 262 ? 121.653 137.625 59.922  1.00 22.26 ? 262 PRO B CB  1 
ATOM   5374 C CG  . PRO B 2 262 ? 122.374 136.341 59.775  1.00 22.26 ? 262 PRO B CG  1 
ATOM   5375 C CD  . PRO B 2 262 ? 123.350 136.298 60.909  1.00 22.26 ? 262 PRO B CD  1 
ATOM   5376 N N   . ALA B 2 263 ? 121.868 139.352 62.617  1.00 21.14 ? 263 ALA B N   1 
ATOM   5377 C CA  . ALA B 2 263 ? 121.275 140.336 63.519  1.00 21.14 ? 263 ALA B CA  1 
ATOM   5378 C C   . ALA B 2 263 ? 122.217 141.513 63.752  1.00 21.14 ? 263 ALA B C   1 
ATOM   5379 O O   . ALA B 2 263 ? 121.812 142.679 63.637  1.00 21.14 ? 263 ALA B O   1 
ATOM   5380 C CB  . ALA B 2 263 ? 120.899 139.673 64.844  1.00 21.14 ? 263 ALA B CB  1 
ATOM   5381 N N   . VAL B 2 264 ? 123.480 141.231 64.079  1.00 20.52 ? 264 VAL B N   1 
ATOM   5382 C CA  . VAL B 2 264 ? 124.433 142.313 64.305  1.00 20.52 ? 264 VAL B CA  1 
ATOM   5383 C C   . VAL B 2 264 ? 124.707 143.061 63.008  1.00 20.52 ? 264 VAL B C   1 
ATOM   5384 O O   . VAL B 2 264 ? 124.905 144.281 63.014  1.00 20.52 ? 264 VAL B O   1 
ATOM   5385 C CB  . VAL B 2 264 ? 125.727 141.780 64.950  1.00 20.52 ? 264 VAL B CB  1 
ATOM   5386 C CG1 . VAL B 2 264 ? 125.427 141.172 66.307  1.00 20.52 ? 264 VAL B CG1 1 
ATOM   5387 C CG2 . VAL B 2 264 ? 126.411 140.765 64.054  1.00 20.52 ? 264 VAL B CG2 1 
ATOM   5388 N N   . CYS B 2 265 ? 124.717 142.353 61.875  1.00 21.24 ? 265 CYS B N   1 
ATOM   5389 C CA  . CYS B 2 265 ? 124.897 143.029 60.595  1.00 21.24 ? 265 CYS B CA  1 
ATOM   5390 C C   . CYS B 2 265 ? 123.755 143.999 60.322  1.00 21.24 ? 265 CYS B C   1 
ATOM   5391 O O   . CYS B 2 265 ? 123.983 145.131 59.882  1.00 21.24 ? 265 CYS B O   1 
ATOM   5392 C CB  . CYS B 2 265 ? 125.012 142.001 59.470  1.00 21.24 ? 265 CYS B CB  1 
ATOM   5393 S SG  . CYS B 2 265 ? 124.881 142.702 57.809  1.00 21.24 ? 265 CYS B SG  1 
ATOM   5394 N N   . ASP B 2 266 ? 122.518 143.576 60.591  1.00 21.99 ? 266 ASP B N   1 
ATOM   5395 C CA  . ASP B 2 266 ? 121.372 144.458 60.398  1.00 21.99 ? 266 ASP B CA  1 
ATOM   5396 C C   . ASP B 2 266 ? 121.432 145.653 61.339  1.00 21.99 ? 266 ASP B C   1 
ATOM   5397 O O   . ASP B 2 266 ? 121.113 146.781 60.944  1.00 21.99 ? 266 ASP B O   1 
ATOM   5398 C CB  . ASP B 2 266 ? 120.073 143.679 60.601  1.00 21.99 ? 266 ASP B CB  1 
ATOM   5399 C CG  . ASP B 2 266 ? 119.849 142.632 59.530  1.00 21.99 ? 266 ASP B CG  1 
ATOM   5400 O OD1 . ASP B 2 266 ? 120.295 142.849 58.383  1.00 21.99 ? 266 ASP B OD1 1 
ATOM   5401 O OD2 . ASP B 2 266 ? 119.230 141.591 59.834  1.00 21.99 ? 266 ASP B OD2 1 
ATOM   5402 N N   . PHE B 2 267 ? 121.834 145.425 62.592  1.00 20.75 ? 267 PHE B N   1 
ATOM   5403 C CA  . PHE B 2 267 ? 121.937 146.530 63.541  1.00 20.75 ? 267 PHE B CA  1 
ATOM   5404 C C   . PHE B 2 267 ? 122.998 147.534 63.107  1.00 20.75 ? 267 PHE B C   1 
ATOM   5405 O O   . PHE B 2 267 ? 122.799 148.749 63.222  1.00 20.75 ? 267 PHE B O   1 
ATOM   5406 C CB  . PHE B 2 267 ? 122.243 145.998 64.938  1.00 20.75 ? 267 PHE B CB  1 
ATOM   5407 C CG  . PHE B 2 267 ? 122.201 147.050 66.009  1.00 20.75 ? 267 PHE B CG  1 
ATOM   5408 C CD1 . PHE B 2 267 ? 120.991 147.552 66.456  1.00 20.75 ? 267 PHE B CD1 1 
ATOM   5409 C CD2 . PHE B 2 267 ? 123.368 147.534 66.571  1.00 20.75 ? 267 PHE B CD2 1 
ATOM   5410 C CE1 . PHE B 2 267 ? 120.946 148.515 67.443  1.00 20.75 ? 267 PHE B CE1 1 
ATOM   5411 C CE2 . PHE B 2 267 ? 123.329 148.496 67.559  1.00 20.75 ? 267 PHE B CE2 1 
ATOM   5412 C CZ  . PHE B 2 267 ? 122.116 148.987 67.995  1.00 20.75 ? 267 PHE B CZ  1 
ATOM   5413 N N   . LEU B 2 268 ? 124.137 147.044 62.609  1.00 19.85 ? 268 LEU B N   1 
ATOM   5414 C CA  . LEU B 2 268 ? 125.192 147.940 62.149  1.00 19.85 ? 268 LEU B CA  1 
ATOM   5415 C C   . LEU B 2 268 ? 124.809 148.648 60.857  1.00 19.85 ? 268 LEU B C   1 
ATOM   5416 O O   . LEU B 2 268 ? 125.302 149.749 60.587  1.00 19.85 ? 268 LEU B O   1 
ATOM   5417 C CB  . LEU B 2 268 ? 126.497 147.167 61.959  1.00 19.85 ? 268 LEU B CB  1 
ATOM   5418 C CG  . LEU B 2 268 ? 127.152 146.569 63.206  1.00 19.85 ? 268 LEU B CG  1 
ATOM   5419 C CD1 . LEU B 2 268 ? 128.639 146.357 62.973  1.00 19.85 ? 268 LEU B CD1 1 
ATOM   5420 C CD2 . LEU B 2 268 ? 126.916 147.443 64.428  1.00 19.85 ? 268 LEU B CD2 1 
ATOM   5421 N N   . GLN B 2 269 ? 123.960 148.031 60.035  1.00 22.06 ? 269 GLN B N   1 
ATOM   5422 C CA  . GLN B 2 269 ? 123.514 148.697 58.817  1.00 22.06 ? 269 GLN B CA  1 
ATOM   5423 C C   . GLN B 2 269 ? 122.462 149.760 59.110  1.00 22.06 ? 269 GLN B C   1 
ATOM   5424 O O   . GLN B 2 269 ? 122.428 150.801 58.444  1.00 22.06 ? 269 GLN B O   1 
ATOM   5425 C CB  . GLN B 2 269 ? 122.975 147.670 57.821  1.00 22.06 ? 269 GLN B CB  1 
ATOM   5426 C CG  . GLN B 2 269 ? 124.053 146.820 57.168  1.00 22.06 ? 269 GLN B CG  1 
ATOM   5427 C CD  . GLN B 2 269 ? 125.030 147.643 56.354  1.00 22.06 ? 269 GLN B CD  1 
ATOM   5428 O OE1 . GLN B 2 269 ? 124.646 148.604 55.687  1.00 22.06 ? 269 GLN B OE1 1 
ATOM   5429 N NE2 . GLN B 2 269 ? 126.304 147.271 56.405  1.00 22.06 ? 269 GLN B NE2 1 
ATOM   5430 N N   . HIS B 2 270 ? 121.595 149.517 60.095  1.00 22.31 ? 270 HIS B N   1 
ATOM   5431 C CA  . HIS B 2 270 ? 120.555 150.489 60.419  1.00 22.31 ? 270 HIS B CA  1 
ATOM   5432 C C   . HIS B 2 270 ? 121.151 151.754 61.026  1.00 22.31 ? 270 HIS B C   1 
ATOM   5433 O O   . HIS B 2 270 ? 120.824 152.870 60.607  1.00 22.31 ? 270 HIS B O   1 
ATOM   5434 C CB  . HIS B 2 270 ? 119.531 149.865 61.366  1.00 22.31 ? 270 HIS B CB  1 
ATOM   5435 C CG  . HIS B 2 270 ? 118.284 150.676 61.526  1.00 22.31 ? 270 HIS B CG  1 
ATOM   5436 N ND1 . HIS B 2 270 ? 118.197 151.745 62.392  1.00 22.31 ? 270 HIS B ND1 1 
ATOM   5437 C CD2 . HIS B 2 270 ? 117.071 150.574 60.932  1.00 22.31 ? 270 HIS B CD2 1 
ATOM   5438 C CE1 . HIS B 2 270 ? 116.985 152.267 62.323  1.00 22.31 ? 270 HIS B CE1 1 
ATOM   5439 N NE2 . HIS B 2 270 ? 116.283 151.575 61.445  1.00 22.31 ? 270 HIS B NE2 1 
ATOM   5440 N N   . ASN B 2 271 ? 122.027 151.599 62.015  1.00 20.36 ? 271 ASN B N   1 
ATOM   5441 C CA  . ASN B 2 271 ? 122.729 152.715 62.636  1.00 20.36 ? 271 ASN B CA  1 
ATOM   5442 C C   . ASN B 2 271 ? 124.206 152.625 62.284  1.00 20.36 ? 271 ASN B C   1 
ATOM   5443 O O   . ASN B 2 271 ? 124.837 151.588 62.507  1.00 20.36 ? 271 ASN B O   1 
ATOM   5444 C CB  . ASN B 2 271 ? 122.546 152.708 64.155  1.00 20.36 ? 271 ASN B CB  1 
ATOM   5445 C CG  . ASN B 2 271 ? 121.146 153.104 64.574  1.00 20.36 ? 271 ASN B CG  1 
ATOM   5446 O OD1 . ASN B 2 271 ? 120.388 152.288 65.096  1.00 20.36 ? 271 ASN B OD1 1 
ATOM   5447 N ND2 . ASN B 2 271 ? 120.797 154.365 64.350  1.00 20.36 ? 271 ASN B ND2 1 
ATOM   5448 N N   . ASN B 2 272 ? 124.755 153.717 61.753  1.00 20.09 ? 272 ASN B N   1 
ATOM   5449 C CA  . ASN B 2 272 ? 126.122 153.703 61.247  1.00 20.09 ? 272 ASN B CA  1 
ATOM   5450 C C   . ASN B 2 272 ? 127.118 153.458 62.372  1.00 20.09 ? 272 ASN B C   1 
ATOM   5451 O O   . ASN B 2 272 ? 127.378 154.348 63.189  1.00 20.09 ? 272 ASN B O   1 
ATOM   5452 C CB  . ASN B 2 272 ? 126.437 155.019 60.534  1.00 20.09 ? 272 ASN B CB  1 
ATOM   5453 C CG  . ASN B 2 272 ? 125.630 155.202 59.265  1.00 20.09 ? 272 ASN B CG  1 
ATOM   5454 O OD1 . ASN B 2 272 ? 125.463 154.267 58.482  1.00 20.09 ? 272 ASN B OD1 1 
ATOM   5455 N ND2 . ASN B 2 272 ? 125.121 156.410 59.057  1.00 20.09 ? 272 ASN B ND2 1 
ATOM   5456 N N   . LEU B 2 273 ? 127.682 152.252 62.414  1.00 19.44 ? 273 LEU B N   1 
ATOM   5457 C CA  . LEU B 2 273 ? 128.649 151.859 63.428  1.00 19.44 ? 273 LEU B CA  1 
ATOM   5458 C C   . LEU B 2 273 ? 129.665 150.927 62.782  1.00 19.44 ? 273 LEU B C   1 
ATOM   5459 O O   . LEU B 2 273 ? 129.600 150.642 61.582  1.00 19.44 ? 273 LEU B O   1 
ATOM   5460 C CB  . LEU B 2 273 ? 127.962 151.191 64.625  1.00 19.44 ? 273 LEU B CB  1 
ATOM   5461 C CG  . LEU B 2 273 ? 127.077 152.078 65.502  1.00 19.44 ? 273 LEU B CG  1 
ATOM   5462 C CD1 . LEU B 2 273 ? 126.254 151.238 66.463  1.00 19.44 ? 273 LEU B CD1 1 
ATOM   5463 C CD2 . LEU B 2 273 ? 127.919 153.093 66.258  1.00 19.44 ? 273 LEU B CD2 1 
ATOM   5464 N N   . LEU B 2 274 ? 130.610 150.451 63.577  1.00 19.90 ? 274 LEU B N   1 
ATOM   5465 C CA  . LEU B 2 274 ? 131.607 149.532 63.038  1.00 19.90 ? 274 LEU B CA  1 
ATOM   5466 C C   . LEU B 2 274 ? 131.710 148.238 63.834  1.00 19.90 ? 274 LEU B C   1 
ATOM   5467 O O   . LEU B 2 274 ? 131.855 147.170 63.236  1.00 19.90 ? 274 LEU B O   1 
ATOM   5468 C CB  . LEU B 2 274 ? 132.981 150.235 62.982  1.00 19.90 ? 274 LEU B CB  1 
ATOM   5469 C CG  . LEU B 2 274 ? 134.260 149.461 62.637  1.00 19.90 ? 274 LEU B CG  1 
ATOM   5470 C CD1 . LEU B 2 274 ? 134.061 148.498 61.472  1.00 19.90 ? 274 LEU B CD1 1 
ATOM   5471 C CD2 . LEU B 2 274 ? 135.397 150.426 62.339  1.00 19.90 ? 274 LEU B CD2 1 
ATOM   5472 N N   . SER B 2 275 ? 131.616 148.300 65.161  1.00 19.62 ? 275 SER B N   1 
ATOM   5473 C CA  . SER B 2 275 ? 131.761 147.102 65.976  1.00 19.62 ? 275 SER B CA  1 
ATOM   5474 C C   . SER B 2 275 ? 131.116 147.330 67.334  1.00 19.62 ? 275 SER B C   1 
ATOM   5475 O O   . SER B 2 275 ? 130.859 148.466 67.740  1.00 19.62 ? 275 SER B O   1 
ATOM   5476 C CB  . SER B 2 275 ? 133.234 146.714 66.140  1.00 19.62 ? 275 SER B CB  1 
ATOM   5477 O OG  . SER B 2 275 ? 133.366 145.560 66.950  1.00 19.62 ? 275 SER B OG  1 
ATOM   5478 N N   . ILE B 2 276 ? 130.861 146.225 68.033  1.00 18.82 ? 276 ILE B N   1 
ATOM   5479 C CA  . ILE B 2 276 ? 130.270 146.238 69.366  1.00 18.82 ? 276 ILE B CA  1 
ATOM   5480 C C   . ILE B 2 276 ? 131.169 145.433 70.295  1.00 18.82 ? 276 ILE B C   1 
ATOM   5481 O O   . ILE B 2 276 ? 131.686 144.377 69.912  1.00 18.82 ? 276 ILE B O   1 
ATOM   5482 C CB  . ILE B 2 276 ? 128.836 145.665 69.368  1.00 18.82 ? 276 ILE B CB  1 
ATOM   5483 C CG1 . ILE B 2 276 ? 128.041 146.179 68.166  1.00 18.82 ? 276 ILE B CG1 1 
ATOM   5484 C CG2 . ILE B 2 276 ? 128.122 146.022 70.661  1.00 18.82 ? 276 ILE B CG2 1 
ATOM   5485 C CD1 . ILE B 2 276 ? 127.727 147.651 68.219  1.00 18.82 ? 276 ILE B CD1 1 
ATOM   5486 N N   . LEU B 2 277 ? 131.348 145.926 71.517  1.00 17.03 ? 277 LEU B N   1 
ATOM   5487 C CA  . LEU B 2 277 ? 132.267 145.341 72.483  1.00 17.03 ? 277 LEU B CA  1 
ATOM   5488 C C   . LEU B 2 277 ? 131.497 144.797 73.681  1.00 17.03 ? 277 LEU B C   1 
ATOM   5489 O O   . LEU B 2 277 ? 130.424 145.297 74.024  1.00 17.03 ? 277 LEU B O   1 
ATOM   5490 C CB  . LEU B 2 277 ? 133.296 146.379 72.946  1.00 17.03 ? 277 LEU B CB  1 
ATOM   5491 C CG  . LEU B 2 277 ? 134.458 146.705 72.001  1.00 17.03 ? 277 LEU B CG  1 
ATOM   5492 C CD1 . LEU B 2 277 ? 134.002 147.556 70.829  1.00 17.03 ? 277 LEU B CD1 1 
ATOM   5493 C CD2 . LEU B 2 277 ? 135.572 147.412 72.751  1.00 17.03 ? 277 LEU B CD2 1 
ATOM   5494 N N   . ARG B 2 278 ? 132.051 143.762 74.312  1.00 13.95 ? 278 ARG B N   1 
ATOM   5495 C CA  . ARG B 2 278 ? 131.381 143.109 75.430  1.00 13.95 ? 278 ARG B CA  1 
ATOM   5496 C C   . ARG B 2 278 ? 132.412 142.504 76.374  1.00 13.95 ? 278 ARG B C   1 
ATOM   5497 O O   . ARG B 2 278 ? 133.574 142.309 76.008  1.00 13.95 ? 278 ARG B O   1 
ATOM   5498 C CB  . ARG B 2 278 ? 130.419 142.027 74.944  1.00 13.95 ? 278 ARG B CB  1 
ATOM   5499 C CG  . ARG B 2 278 ? 131.048 141.030 74.001  1.00 13.95 ? 278 ARG B CG  1 
ATOM   5500 C CD  . ARG B 2 278 ? 130.007 140.065 73.485  1.00 13.95 ? 278 ARG B CD  1 
ATOM   5501 N NE  . ARG B 2 278 ? 129.467 139.246 74.564  1.00 13.95 ? 278 ARG B NE  1 
ATOM   5502 C CZ  . ARG B 2 278 ? 130.064 138.161 75.045  1.00 13.95 ? 278 ARG B CZ  1 
ATOM   5503 N NH1 . ARG B 2 278 ? 131.224 137.764 74.543  1.00 13.95 ? 278 ARG B NH1 1 
ATOM   5504 N NH2 . ARG B 2 278 ? 129.500 137.474 76.026  1.00 13.95 ? 278 ARG B NH2 1 
ATOM   5505 N N   . ALA B 2 279 ? 131.974 142.215 77.603  1.00 8.69  ? 279 ALA B N   1 
ATOM   5506 C CA  . ALA B 2 279 ? 132.885 141.755 78.648  1.00 8.69  ? 279 ALA B CA  1 
ATOM   5507 C C   . ALA B 2 279 ? 132.275 140.654 79.517  1.00 8.69  ? 279 ALA B C   1 
ATOM   5508 O O   . ALA B 2 279 ? 132.406 140.681 80.745  1.00 8.69  ? 279 ALA B O   1 
ATOM   5509 C CB  . ALA B 2 279 ? 133.337 142.920 79.525  1.00 8.69  ? 279 ALA B CB  1 
ATOM   5510 N N   . HIS B 2 280 ? 131.607 139.665 78.916  1.00 10.61 ? 280 HIS B N   1 
ATOM   5511 C CA  . HIS B 2 280 ? 131.209 138.475 79.676  1.00 10.61 ? 280 HIS B CA  1 
ATOM   5512 C C   . HIS B 2 280 ? 132.209 137.329 79.575  1.00 10.61 ? 280 HIS B C   1 
ATOM   5513 O O   . HIS B 2 280 ? 132.742 136.874 80.591  1.00 10.61 ? 280 HIS B O   1 
ATOM   5514 C CB  . HIS B 2 280 ? 129.833 137.953 79.246  1.00 10.61 ? 280 HIS B CB  1 
ATOM   5515 C CG  . HIS B 2 280 ? 128.681 138.776 79.723  1.00 10.61 ? 280 HIS B CG  1 
ATOM   5516 N ND1 . HIS B 2 280 ? 127.394 138.573 79.276  1.00 10.61 ? 280 HIS B ND1 1 
ATOM   5517 C CD2 . HIS B 2 280 ? 128.604 139.744 80.665  1.00 10.61 ? 280 HIS B CD2 1 
ATOM   5518 C CE1 . HIS B 2 280 ? 126.580 139.412 79.889  1.00 10.61 ? 280 HIS B CE1 1 
ATOM   5519 N NE2 . HIS B 2 280 ? 127.289 140.134 80.737  1.00 10.61 ? 280 HIS B NE2 1 
ATOM   5520 N N   . GLU B 2 281 ? 132.453 136.840 78.364  1.00 16.40 ? 281 GLU B N   1 
ATOM   5521 C CA  . GLU B 2 281 ? 133.112 135.550 78.185  1.00 16.40 ? 281 GLU B CA  1 
ATOM   5522 C C   . GLU B 2 281 ? 134.534 135.604 78.726  1.00 16.40 ? 281 GLU B C   1 
ATOM   5523 O O   . GLU B 2 281 ? 135.416 136.221 78.120  1.00 16.40 ? 281 GLU B O   1 
ATOM   5524 C CB  . GLU B 2 281 ? 133.103 135.156 76.711  1.00 16.40 ? 281 GLU B CB  1 
ATOM   5525 C CG  . GLU B 2 281 ? 131.712 134.936 76.142  1.00 16.40 ? 281 GLU B CG  1 
ATOM   5526 C CD  . GLU B 2 281 ? 131.700 133.945 74.996  1.00 16.40 ? 281 GLU B CD  1 
ATOM   5527 O OE1 . GLU B 2 281 ? 132.789 133.475 74.603  1.00 16.40 ? 281 GLU B OE1 1 
ATOM   5528 O OE2 . GLU B 2 281 ? 130.603 133.635 74.489  1.00 16.40 ? 281 GLU B OE2 1 
ATOM   5529 N N   . ALA B 2 282 ? 134.754 134.964 79.872  1.00 14.78 ? 282 ALA B N   1 
ATOM   5530 C CA  . ALA B 2 282 ? 136.108 134.779 80.369  1.00 14.78 ? 282 ALA B CA  1 
ATOM   5531 C C   . ALA B 2 282 ? 136.889 133.921 79.388  1.00 14.78 ? 282 ALA B C   1 
ATOM   5532 O O   . ALA B 2 282 ? 136.421 132.861 78.963  1.00 14.78 ? 282 ALA B O   1 
ATOM   5533 C CB  . ALA B 2 282 ? 136.083 134.127 81.750  1.00 14.78 ? 282 ALA B CB  1 
ATOM   5534 N N   . GLN B 2 283 ? 138.082 134.380 79.023  1.00 16.85 ? 283 GLN B N   1 
ATOM   5535 C CA  . GLN B 2 283 ? 138.826 133.769 77.934  1.00 16.85 ? 283 GLN B CA  1 
ATOM   5536 C C   . GLN B 2 283 ? 140.283 133.590 78.319  1.00 16.85 ? 283 GLN B C   1 
ATOM   5537 O O   . GLN B 2 283 ? 140.880 134.465 78.951  1.00 16.85 ? 283 GLN B O   1 
ATOM   5538 C CB  . GLN B 2 283 ? 138.717 134.619 76.669  1.00 16.85 ? 283 GLN B CB  1 
ATOM   5539 C CG  . GLN B 2 283 ? 137.321 134.647 76.094  1.00 16.85 ? 283 GLN B CG  1 
ATOM   5540 C CD  . GLN B 2 283 ? 137.220 135.543 74.892  1.00 16.85 ? 283 GLN B CD  1 
ATOM   5541 O OE1 . GLN B 2 283 ? 138.179 136.227 74.538  1.00 16.85 ? 283 GLN B OE1 1 
ATOM   5542 N NE2 . GLN B 2 283 ? 136.059 135.545 74.250  1.00 16.85 ? 283 GLN B NE2 1 
ATOM   5543 N N   . ASP B 2 284 ? 140.849 132.448 77.923  1.00 15.46 ? 284 ASP B N   1 
ATOM   5544 C CA  . ASP B 2 284 ? 142.253 132.177 78.210  1.00 15.46 ? 284 ASP B CA  1 
ATOM   5545 C C   . ASP B 2 284 ? 143.160 133.173 77.499  1.00 15.46 ? 284 ASP B C   1 
ATOM   5546 O O   . ASP B 2 284 ? 144.151 133.641 78.071  1.00 15.46 ? 284 ASP B O   1 
ATOM   5547 C CB  . ASP B 2 284 ? 142.599 130.746 77.805  1.00 15.46 ? 284 ASP B CB  1 
ATOM   5548 C CG  . ASP B 2 284 ? 141.927 129.714 78.688  1.00 15.46 ? 284 ASP B CG  1 
ATOM   5549 O OD1 . ASP B 2 284 ? 141.673 130.017 79.873  1.00 15.46 ? 284 ASP B OD1 1 
ATOM   5550 O OD2 . ASP B 2 284 ? 141.649 128.600 78.197  1.00 15.46 ? 284 ASP B OD2 1 
ATOM   5551 N N   . ALA B 2 285 ? 142.838 133.506 76.248  1.00 16.76 ? 285 ALA B N   1 
ATOM   5552 C CA  . ALA B 2 285 ? 143.620 134.491 75.513  1.00 16.76 ? 285 ALA B CA  1 
ATOM   5553 C C   . ALA B 2 285 ? 143.410 135.906 76.035  1.00 16.76 ? 285 ALA B C   1 
ATOM   5554 O O   . ALA B 2 285 ? 144.286 136.757 75.851  1.00 16.76 ? 285 ALA B O   1 
ATOM   5555 C CB  . ALA B 2 285 ? 143.278 134.429 74.024  1.00 16.76 ? 285 ALA B CB  1 
ATOM   5556 N N   . GLY B 2 286 ? 142.280 136.174 76.679  1.00 16.34 ? 286 GLY B N   1 
ATOM   5557 C CA  . GLY B 2 286 ? 141.965 137.486 77.219  1.00 16.34 ? 286 GLY B CA  1 
ATOM   5558 C C   . GLY B 2 286 ? 141.114 138.351 76.317  1.00 16.34 ? 286 GLY B C   1 
ATOM   5559 O O   . GLY B 2 286 ? 140.254 139.093 76.795  1.00 16.34 ? 286 GLY B O   1 
ATOM   5560 N N   . TYR B 2 287 ? 141.344 138.273 75.010  1.00 20.53 ? 287 TYR B N   1 
ATOM   5561 C CA  . TYR B 2 287 ? 140.572 139.018 74.030  1.00 20.53 ? 287 TYR B CA  1 
ATOM   5562 C C   . TYR B 2 287 ? 140.182 138.088 72.894  1.00 20.53 ? 287 TYR B C   1 
ATOM   5563 O O   . TYR B 2 287 ? 140.910 137.148 72.564  1.00 20.53 ? 287 TYR B O   1 
ATOM   5564 C CB  . TYR B 2 287 ? 141.362 140.209 73.474  1.00 20.53 ? 287 TYR B CB  1 
ATOM   5565 C CG  . TYR B 2 287 ? 142.515 139.808 72.582  1.00 20.53 ? 287 TYR B CG  1 
ATOM   5566 C CD1 . TYR B 2 287 ? 143.706 139.340 73.121  1.00 20.53 ? 287 TYR B CD1 1 
ATOM   5567 C CD2 . TYR B 2 287 ? 142.415 139.905 71.202  1.00 20.53 ? 287 TYR B CD2 1 
ATOM   5568 C CE1 . TYR B 2 287 ? 144.762 138.974 72.310  1.00 20.53 ? 287 TYR B CE1 1 
ATOM   5569 C CE2 . TYR B 2 287 ? 143.465 139.542 70.382  1.00 20.53 ? 287 TYR B CE2 1 
ATOM   5570 C CZ  . TYR B 2 287 ? 144.636 139.077 70.942  1.00 20.53 ? 287 TYR B CZ  1 
ATOM   5571 O OH  . TYR B 2 287 ? 145.685 138.715 70.129  1.00 20.53 ? 287 TYR B OH  1 
ATOM   5572 N N   . ARG B 2 288 ? 139.024 138.353 72.295  1.00 21.06 ? 288 ARG B N   1 
ATOM   5573 C CA  . ARG B 2 288 ? 138.581 137.570 71.151  1.00 21.06 ? 288 ARG B CA  1 
ATOM   5574 C C   . ARG B 2 288 ? 137.929 138.474 70.119  1.00 21.06 ? 288 ARG B C   1 
ATOM   5575 O O   . ARG B 2 288 ? 137.097 139.323 70.459  1.00 21.06 ? 288 ARG B O   1 
ATOM   5576 C CB  . ARG B 2 288 ? 137.605 136.465 71.561  1.00 21.06 ? 288 ARG B CB  1 
ATOM   5577 C CG  . ARG B 2 288 ? 137.456 135.368 70.523  1.00 21.06 ? 288 ARG B CG  1 
ATOM   5578 C CD  . ARG B 2 288 ? 136.717 134.166 71.085  1.00 21.06 ? 288 ARG B CD  1 
ATOM   5579 N NE  . ARG B 2 288 ? 136.277 133.261 70.027  1.00 21.06 ? 288 ARG B NE  1 
ATOM   5580 C CZ  . ARG B 2 288 ? 135.408 132.272 70.203  1.00 21.06 ? 288 ARG B CZ  1 
ATOM   5581 N NH1 . ARG B 2 288 ? 134.878 132.056 71.399  1.00 21.06 ? 288 ARG B NH1 1 
ATOM   5582 N NH2 . ARG B 2 288 ? 135.067 131.498 69.182  1.00 21.06 ? 288 ARG B NH2 1 
ATOM   5583 N N   . MET B 2 289 ? 138.318 138.278 68.865  1.00 23.10 ? 289 MET B N   1 
ATOM   5584 C CA  . MET B 2 289 ? 137.697 138.928 67.722  1.00 23.10 ? 289 MET B CA  1 
ATOM   5585 C C   . MET B 2 289 ? 136.802 137.907 67.032  1.00 23.10 ? 289 MET B C   1 
ATOM   5586 O O   . MET B 2 289 ? 137.285 136.872 66.561  1.00 23.10 ? 289 MET B O   1 
ATOM   5587 C CB  . MET B 2 289 ? 138.757 139.453 66.756  1.00 23.10 ? 289 MET B CB  1 
ATOM   5588 C CG  . MET B 2 289 ? 139.596 140.591 67.307  1.00 23.10 ? 289 MET B CG  1 
ATOM   5589 S SD  . MET B 2 289 ? 140.833 141.158 66.125  1.00 23.10 ? 289 MET B SD  1 
ATOM   5590 C CE  . MET B 2 289 ? 141.687 142.396 67.094  1.00 23.10 ? 289 MET B CE  1 
ATOM   5591 N N   . TYR B 2 290 ? 135.507 138.195 66.973  1.00 25.39 ? 290 TYR B N   1 
ATOM   5592 C CA  . TYR B 2 290 ? 134.558 137.291 66.340  1.00 25.39 ? 290 TYR B CA  1 
ATOM   5593 C C   . TYR B 2 290 ? 134.616 137.452 64.823  1.00 25.39 ? 290 TYR B C   1 
ATOM   5594 O O   . TYR B 2 290 ? 135.551 138.038 64.270  1.00 25.39 ? 290 TYR B O   1 
ATOM   5595 C CB  . TYR B 2 290 ? 133.154 137.507 66.895  1.00 25.39 ? 290 TYR B CB  1 
ATOM   5596 C CG  . TYR B 2 290 ? 132.996 137.075 68.334  1.00 25.39 ? 290 TYR B CG  1 
ATOM   5597 C CD1 . TYR B 2 290 ? 133.946 136.271 68.947  1.00 25.39 ? 290 TYR B CD1 1 
ATOM   5598 C CD2 . TYR B 2 290 ? 131.882 137.443 69.069  1.00 25.39 ? 290 TYR B CD2 1 
ATOM   5599 C CE1 . TYR B 2 290 ? 133.799 135.863 70.256  1.00 25.39 ? 290 TYR B CE1 1 
ATOM   5600 C CE2 . TYR B 2 290 ? 131.726 137.042 70.379  1.00 25.39 ? 290 TYR B CE2 1 
ATOM   5601 C CZ  . TYR B 2 290 ? 132.687 136.251 70.967  1.00 25.39 ? 290 TYR B CZ  1 
ATOM   5602 O OH  . TYR B 2 290 ? 132.535 135.848 72.273  1.00 25.39 ? 290 TYR B OH  1 
ATOM   5603 N N   . ARG B 2 291 ? 133.610 136.904 64.141  1.00 22.27 ? 291 ARG B N   1 
ATOM   5604 C CA  . ARG B 2 291 ? 133.648 136.758 62.691  1.00 22.27 ? 291 ARG B CA  1 
ATOM   5605 C C   . ARG B 2 291 ? 133.946 138.085 62.006  1.00 22.27 ? 291 ARG B C   1 
ATOM   5606 O O   . ARG B 2 291 ? 133.303 139.103 62.277  1.00 22.27 ? 291 ARG B O   1 
ATOM   5607 C CB  . ARG B 2 291 ? 132.318 136.197 62.190  1.00 22.27 ? 291 ARG B CB  1 
ATOM   5608 C CG  . ARG B 2 291 ? 132.342 135.731 60.745  1.00 22.27 ? 291 ARG B CG  1 
ATOM   5609 C CD  . ARG B 2 291 ? 130.956 135.311 60.287  1.00 22.27 ? 291 ARG B CD  1 
ATOM   5610 N NE  . ARG B 2 291 ? 130.993 134.594 59.016  1.00 22.27 ? 291 ARG B NE  1 
ATOM   5611 C CZ  . ARG B 2 291 ? 131.180 133.282 58.906  1.00 22.27 ? 291 ARG B CZ  1 
ATOM   5612 N NH1 . ARG B 2 291 ? 131.346 132.540 59.992  1.00 22.27 ? 291 ARG B NH1 1 
ATOM   5613 N NH2 . ARG B 2 291 ? 131.198 132.711 57.709  1.00 22.27 ? 291 ARG B NH2 1 
ATOM   5614 N N   . LYS B 2 292 ? 134.933 138.060 61.117  1.00 22.71 ? 292 LYS B N   1 
ATOM   5615 C CA  . LYS B 2 292 ? 135.338 139.247 60.383  1.00 22.71 ? 292 LYS B CA  1 
ATOM   5616 C C   . LYS B 2 292 ? 134.214 139.717 59.465  1.00 22.71 ? 292 LYS B C   1 
ATOM   5617 O O   . LYS B 2 292 ? 133.590 138.928 58.752  1.00 22.71 ? 292 LYS B O   1 
ATOM   5618 C CB  . LYS B 2 292 ? 136.611 138.945 59.587  1.00 22.71 ? 292 LYS B CB  1 
ATOM   5619 C CG  . LYS B 2 292 ? 137.352 140.149 59.036  1.00 22.71 ? 292 LYS B CG  1 
ATOM   5620 C CD  . LYS B 2 292 ? 136.829 140.546 57.669  1.00 22.71 ? 292 LYS B CD  1 
ATOM   5621 C CE  . LYS B 2 292 ? 137.182 139.504 56.619  1.00 22.71 ? 292 LYS B CE  1 
ATOM   5622 N NZ  . LYS B 2 292 ? 136.534 139.789 55.309  1.00 22.71 ? 292 LYS B NZ  1 
ATOM   5623 N N   . SER B 2 293 ? 133.954 141.023 59.497  1.00 20.69 ? 293 SER B N   1 
ATOM   5624 C CA  . SER B 2 293 ? 132.926 141.591 58.636  1.00 20.69 ? 293 SER B CA  1 
ATOM   5625 C C   . SER B 2 293 ? 133.436 141.669 57.204  1.00 20.69 ? 293 SER B C   1 
ATOM   5626 O O   . SER B 2 293 ? 134.383 142.401 56.907  1.00 20.69 ? 293 SER B O   1 
ATOM   5627 C CB  . SER B 2 293 ? 132.521 142.980 59.128  1.00 20.69 ? 293 SER B CB  1 
ATOM   5628 O OG  . SER B 2 293 ? 133.660 143.783 59.376  1.00 20.69 ? 293 SER B OG  1 
ATOM   5629 N N   . GLN B 2 294 ? 132.788 140.918 56.313  1.00 20.03 ? 294 GLN B N   1 
ATOM   5630 C CA  . GLN B 2 294 ? 133.245 140.847 54.930  1.00 20.03 ? 294 GLN B CA  1 
ATOM   5631 C C   . GLN B 2 294 ? 133.093 142.188 54.220  1.00 20.03 ? 294 GLN B C   1 
ATOM   5632 O O   . GLN B 2 294 ? 133.857 142.489 53.296  1.00 20.03 ? 294 GLN B O   1 
ATOM   5633 C CB  . GLN B 2 294 ? 132.479 139.747 54.193  1.00 20.03 ? 294 GLN B CB  1 
ATOM   5634 C CG  . GLN B 2 294 ? 132.839 139.580 52.728  1.00 20.03 ? 294 GLN B CG  1 
ATOM   5635 C CD  . GLN B 2 294 ? 132.079 138.444 52.074  1.00 20.03 ? 294 GLN B CD  1 
ATOM   5636 O OE1 . GLN B 2 294 ? 131.281 137.764 52.718  1.00 20.03 ? 294 GLN B OE1 1 
ATOM   5637 N NE2 . GLN B 2 294 ? 132.325 138.231 50.786  1.00 20.03 ? 294 GLN B NE2 1 
ATOM   5638 N N   . THR B 2 295 ? 132.127 143.006 54.645  1.00 21.40 ? 295 THR B N   1 
ATOM   5639 C CA  . THR B 2 295 ? 131.897 144.288 53.988  1.00 21.40 ? 295 THR B CA  1 
ATOM   5640 C C   . THR B 2 295 ? 133.066 145.247 54.189  1.00 21.40 ? 295 THR B C   1 
ATOM   5641 O O   . THR B 2 295 ? 133.492 145.918 53.242  1.00 21.40 ? 295 THR B O   1 
ATOM   5642 C CB  . THR B 2 295 ? 130.601 144.915 54.502  1.00 21.40 ? 295 THR B CB  1 
ATOM   5643 O OG1 . THR B 2 295 ? 130.719 145.181 55.905  1.00 21.40 ? 295 THR B OG1 1 
ATOM   5644 C CG2 . THR B 2 295 ? 129.427 143.977 54.269  1.00 21.40 ? 295 THR B CG2 1 
ATOM   5645 N N   . THR B 2 296 ? 133.602 145.326 55.407  1.00 22.45 ? 296 THR B N   1 
ATOM   5646 C CA  . THR B 2 296 ? 134.614 146.323 55.736  1.00 22.45 ? 296 THR B CA  1 
ATOM   5647 C C   . THR B 2 296 ? 135.982 145.748 56.071  1.00 22.45 ? 296 THR B C   1 
ATOM   5648 O O   . THR B 2 296 ? 136.987 146.422 55.836  1.00 22.45 ? 296 THR B O   1 
ATOM   5649 C CB  . THR B 2 296 ? 134.149 147.189 56.920  1.00 22.45 ? 296 THR B CB  1 
ATOM   5650 O OG1 . THR B 2 296 ? 134.050 146.380 58.098  1.00 22.45 ? 296 THR B OG1 1 
ATOM   5651 C CG2 . THR B 2 296 ? 132.795 147.816 56.624  1.00 22.45 ? 296 THR B CG2 1 
ATOM   5652 N N   . GLY B 2 297 ? 136.055 144.532 56.608  1.00 21.11 ? 297 GLY B N   1 
ATOM   5653 C CA  . GLY B 2 297 ? 137.317 143.919 56.962  1.00 21.11 ? 297 GLY B CA  1 
ATOM   5654 C C   . GLY B 2 297 ? 137.647 143.926 58.441  1.00 21.11 ? 297 GLY B C   1 
ATOM   5655 O O   . GLY B 2 297 ? 138.532 143.171 58.862  1.00 21.11 ? 297 GLY B O   1 
ATOM   5656 N N   . PHE B 2 298 ? 136.971 144.750 59.238  1.00 25.41 ? 298 PHE B N   1 
ATOM   5657 C CA  . PHE B 2 298 ? 137.219 144.780 60.669  1.00 25.41 ? 298 PHE B CA  1 
ATOM   5658 C C   . PHE B 2 298 ? 136.229 143.874 61.401  1.00 25.41 ? 298 PHE B C   1 
ATOM   5659 O O   . PHE B 2 298 ? 135.072 143.753 60.992  1.00 25.41 ? 298 PHE B O   1 
ATOM   5660 C CB  . PHE B 2 298 ? 137.104 146.207 61.195  1.00 25.41 ? 298 PHE B CB  1 
ATOM   5661 C CG  . PHE B 2 298 ? 137.849 146.445 62.476  1.00 25.41 ? 298 PHE B CG  1 
ATOM   5662 C CD1 . PHE B 2 298 ? 139.221 146.623 62.469  1.00 25.41 ? 298 PHE B CD1 1 
ATOM   5663 C CD2 . PHE B 2 298 ? 137.177 146.497 63.686  1.00 25.41 ? 298 PHE B CD2 1 
ATOM   5664 C CE1 . PHE B 2 298 ? 139.912 146.843 63.645  1.00 25.41 ? 298 PHE B CE1 1 
ATOM   5665 C CE2 . PHE B 2 298 ? 137.863 146.718 64.866  1.00 25.41 ? 298 PHE B CE2 1 
ATOM   5666 C CZ  . PHE B 2 298 ? 139.232 146.891 64.845  1.00 25.41 ? 298 PHE B CZ  1 
ATOM   5667 N N   . PRO B 2 299 ? 136.661 143.221 62.481  1.00 24.48 ? 299 PRO B N   1 
ATOM   5668 C CA  . PRO B 2 299 ? 135.734 142.373 63.243  1.00 24.48 ? 299 PRO B CA  1 
ATOM   5669 C C   . PRO B 2 299 ? 134.568 143.182 63.793  1.00 24.48 ? 299 PRO B C   1 
ATOM   5670 O O   . PRO B 2 299 ? 134.721 144.338 64.193  1.00 24.48 ? 299 PRO B O   1 
ATOM   5671 C CB  . PRO B 2 299 ? 136.607 141.803 64.368  1.00 24.48 ? 299 PRO B CB  1 
ATOM   5672 C CG  . PRO B 2 299 ? 137.845 142.644 64.385  1.00 24.48 ? 299 PRO B CG  1 
ATOM   5673 C CD  . PRO B 2 299 ? 138.039 143.130 62.989  1.00 24.48 ? 299 PRO B CD  1 
ATOM   5674 N N   . SER B 2 300 ? 133.391 142.556 63.811  1.00 21.04 ? 300 SER B N   1 
ATOM   5675 C CA  . SER B 2 300 ? 132.161 143.233 64.197  1.00 21.04 ? 300 SER B CA  1 
ATOM   5676 C C   . SER B 2 300 ? 131.826 143.103 65.676  1.00 21.04 ? 300 SER B C   1 
ATOM   5677 O O   . SER B 2 300 ? 131.115 143.962 66.208  1.00 21.04 ? 300 SER B O   1 
ATOM   5678 C CB  . SER B 2 300 ? 130.983 142.698 63.374  1.00 21.04 ? 300 SER B CB  1 
ATOM   5679 O OG  . SER B 2 300 ? 130.881 141.290 63.493  1.00 21.04 ? 300 SER B OG  1 
ATOM   5680 N N   . LEU B 2 301 ? 132.304 142.059 66.348  1.00 21.40 ? 301 LEU B N   1 
ATOM   5681 C CA  . LEU B 2 301 ? 132.052 141.867 67.770  1.00 21.40 ? 301 LEU B CA  1 
ATOM   5682 C C   . LEU B 2 301 ? 133.364 141.550 68.467  1.00 21.40 ? 301 LEU B C   1 
ATOM   5683 O O   . LEU B 2 301 ? 134.121 140.688 68.011  1.00 21.40 ? 301 LEU B O   1 
ATOM   5684 C CB  . LEU B 2 301 ? 131.032 140.750 68.010  1.00 21.40 ? 301 LEU B CB  1 
ATOM   5685 C CG  . LEU B 2 301 ? 130.158 140.923 69.254  1.00 21.40 ? 301 LEU B CG  1 
ATOM   5686 C CD1 . LEU B 2 301 ? 129.244 142.121 69.090  1.00 21.40 ? 301 LEU B CD1 1 
ATOM   5687 C CD2 . LEU B 2 301 ? 129.343 139.672 69.525  1.00 21.40 ? 301 LEU B CD2 1 
ATOM   5688 N N   . ILE B 2 302 ? 133.626 142.244 69.572  1.00 19.77 ? 302 ILE B N   1 
ATOM   5689 C CA  . ILE B 2 302 ? 134.870 142.113 70.320  1.00 19.77 ? 302 ILE B CA  1 
ATOM   5690 C C   . ILE B 2 302 ? 134.529 141.709 71.746  1.00 19.77 ? 302 ILE B C   1 
ATOM   5691 O O   . ILE B 2 302 ? 133.625 142.289 72.360  1.00 19.77 ? 302 ILE B O   1 
ATOM   5692 C CB  . ILE B 2 302 ? 135.679 143.423 70.304  1.00 19.77 ? 302 ILE B CB  1 
ATOM   5693 C CG1 . ILE B 2 302 ? 136.007 143.828 68.867  1.00 19.77 ? 302 ILE B CG1 1 
ATOM   5694 C CG2 . ILE B 2 302 ? 136.954 143.269 71.112  1.00 19.77 ? 302 ILE B CG2 1 
ATOM   5695 C CD1 . ILE B 2 302 ? 136.842 142.816 68.129  1.00 19.77 ? 302 ILE B CD1 1 
ATOM   5696 N N   . THR B 2 303 ? 135.235 140.706 72.265  1.00 16.19 ? 303 THR B N   1 
ATOM   5697 C CA  . THR B 2 303 ? 135.065 140.259 73.641  1.00 16.19 ? 303 THR B CA  1 
ATOM   5698 C C   . THR B 2 303 ? 136.351 140.524 74.407  1.00 16.19 ? 303 THR B C   1 
ATOM   5699 O O   . THR B 2 303 ? 137.431 140.116 73.968  1.00 16.19 ? 303 THR B O   1 
ATOM   5700 C CB  . THR B 2 303 ? 134.707 138.773 73.703  1.00 16.19 ? 303 THR B CB  1 
ATOM   5701 O OG1 . THR B 2 303 ? 133.477 138.549 73.003  1.00 16.19 ? 303 THR B OG1 1 
ATOM   5702 C CG2 . THR B 2 303 ? 134.550 138.328 75.147  1.00 16.19 ? 303 THR B CG2 1 
ATOM   5703 N N   . ILE B 2 304 ? 136.235 141.205 75.546  1.00 13.38 ? 304 ILE B N   1 
ATOM   5704 C CA  . ILE B 2 304 ? 137.386 141.607 76.345  1.00 13.38 ? 304 ILE B CA  1 
ATOM   5705 C C   . ILE B 2 304 ? 137.204 141.100 77.767  1.00 13.38 ? 304 ILE B C   1 
ATOM   5706 O O   . ILE B 2 304 ? 136.127 141.249 78.351  1.00 13.38 ? 304 ILE B O   1 
ATOM   5707 C CB  . ILE B 2 304 ? 137.578 143.134 76.350  1.00 13.38 ? 304 ILE B CB  1 
ATOM   5708 C CG1 . ILE B 2 304 ? 137.405 143.702 74.945  1.00 13.38 ? 304 ILE B CG1 1 
ATOM   5709 C CG2 . ILE B 2 304 ? 138.941 143.494 76.902  1.00 13.38 ? 304 ILE B CG2 1 
ATOM   5710 C CD1 . ILE B 2 304 ? 137.350 145.202 74.916  1.00 13.38 ? 304 ILE B CD1 1 
ATOM   5711 N N   . PHE B 2 305 ? 138.257 140.506 78.320  1.00 12.31 ? 305 PHE B N   1 
ATOM   5712 C CA  . PHE B 2 305 ? 138.288 140.089 79.714  1.00 12.31 ? 305 PHE B CA  1 
ATOM   5713 C C   . PHE B 2 305 ? 139.575 140.603 80.338  1.00 12.31 ? 305 PHE B C   1 
ATOM   5714 O O   . PHE B 2 305 ? 140.659 140.398 79.784  1.00 12.31 ? 305 PHE B O   1 
ATOM   5715 C CB  . PHE B 2 305 ? 138.201 138.569 79.837  1.00 12.31 ? 305 PHE B CB  1 
ATOM   5716 C CG  . PHE B 2 305 ? 137.824 138.096 81.204  1.00 12.31 ? 305 PHE B CG  1 
ATOM   5717 C CD1 . PHE B 2 305 ? 138.789 137.642 82.081  1.00 12.31 ? 305 PHE B CD1 1 
ATOM   5718 C CD2 . PHE B 2 305 ? 136.505 138.106 81.614  1.00 12.31 ? 305 PHE B CD2 1 
ATOM   5719 C CE1 . PHE B 2 305 ? 138.446 137.203 83.339  1.00 12.31 ? 305 PHE B CE1 1 
ATOM   5720 C CE2 . PHE B 2 305 ? 136.156 137.669 82.871  1.00 12.31 ? 305 PHE B CE2 1 
ATOM   5721 C CZ  . PHE B 2 305 ? 137.128 137.218 83.736  1.00 12.31 ? 305 PHE B CZ  1 
ATOM   5722 N N   . SER B 2 306 ? 139.460 141.269 81.484  1.00 10.30 ? 306 SER B N   1 
ATOM   5723 C CA  . SER B 2 306 ? 140.593 141.931 82.121  1.00 10.30 ? 306 SER B CA  1 
ATOM   5724 C C   . SER B 2 306 ? 140.674 141.568 83.597  1.00 10.30 ? 306 SER B C   1 
ATOM   5725 O O   . SER B 2 306 ? 140.860 142.423 84.465  1.00 10.30 ? 306 SER B O   1 
ATOM   5726 C CB  . SER B 2 306 ? 140.503 143.440 81.944  1.00 10.30 ? 306 SER B CB  1 
ATOM   5727 O OG  . SER B 2 306 ? 139.630 144.003 82.905  1.00 10.30 ? 306 SER B OG  1 
ATOM   5728 N N   . ALA B 2 307 ? 140.532 140.280 83.901  1.00 9.59  ? 307 ALA B N   1 
ATOM   5729 C CA  . ALA B 2 307 ? 140.680 139.762 85.260  1.00 9.59  ? 307 ALA B CA  1 
ATOM   5730 C C   . ALA B 2 307 ? 141.575 138.532 85.205  1.00 9.59  ? 307 ALA B C   1 
ATOM   5731 O O   . ALA B 2 307 ? 141.085 137.402 85.078  1.00 9.59  ? 307 ALA B O   1 
ATOM   5732 C CB  . ALA B 2 307 ? 139.325 139.436 85.882  1.00 9.59  ? 307 ALA B CB  1 
ATOM   5733 N N   . PRO B 2 308 ? 142.892 138.713 85.284  1.00 11.64 ? 308 PRO B N   1 
ATOM   5734 C CA  . PRO B 2 308 ? 143.801 137.565 85.182  1.00 11.64 ? 308 PRO B CA  1 
ATOM   5735 C C   . PRO B 2 308 ? 143.614 136.597 86.340  1.00 11.64 ? 308 PRO B C   1 
ATOM   5736 O O   . PRO B 2 308 ? 143.348 137.002 87.473  1.00 11.64 ? 308 PRO B O   1 
ATOM   5737 C CB  . PRO B 2 308 ? 145.188 138.212 85.209  1.00 11.64 ? 308 PRO B CB  1 
ATOM   5738 C CG  . PRO B 2 308 ? 144.982 139.488 85.937  1.00 11.64 ? 308 PRO B CG  1 
ATOM   5739 C CD  . PRO B 2 308 ? 143.614 139.965 85.557  1.00 11.64 ? 308 PRO B CD  1 
ATOM   5740 N N   . ASN B 2 309 ? 143.774 135.309 86.044  1.00 13.62 ? 309 ASN B N   1 
ATOM   5741 C CA  . ASN B 2 309 ? 143.574 134.232 87.012  1.00 13.62 ? 309 ASN B CA  1 
ATOM   5742 C C   . ASN B 2 309 ? 142.197 134.337 87.664  1.00 13.62 ? 309 ASN B C   1 
ATOM   5743 O O   . ASN B 2 309 ? 142.057 134.456 88.882  1.00 13.62 ? 309 ASN B O   1 
ATOM   5744 C CB  . ASN B 2 309 ? 144.684 134.222 88.067  1.00 13.62 ? 309 ASN B CB  1 
ATOM   5745 C CG  . ASN B 2 309 ? 145.877 133.387 87.649  1.00 13.62 ? 309 ASN B CG  1 
ATOM   5746 O OD1 . ASN B 2 309 ? 146.960 133.913 87.394  1.00 13.62 ? 309 ASN B OD1 1 
ATOM   5747 N ND2 . ASN B 2 309 ? 145.685 132.075 87.583  1.00 13.62 ? 309 ASN B ND2 1 
ATOM   5748 N N   . TYR B 2 310 ? 141.172 134.300 86.817  1.00 13.88 ? 310 TYR B N   1 
ATOM   5749 C CA  . TYR B 2 310 ? 139.801 134.362 87.302  1.00 13.88 ? 310 TYR B CA  1 
ATOM   5750 C C   . TYR B 2 310 ? 139.497 133.144 88.165  1.00 13.88 ? 310 TYR B C   1 
ATOM   5751 O O   . TYR B 2 310 ? 139.749 132.005 87.763  1.00 13.88 ? 310 TYR B O   1 
ATOM   5752 C CB  . TYR B 2 310 ? 138.836 134.444 86.119  1.00 13.88 ? 310 TYR B CB  1 
ATOM   5753 C CG  . TYR B 2 310 ? 137.387 134.648 86.497  1.00 13.88 ? 310 TYR B CG  1 
ATOM   5754 C CD1 . TYR B 2 310 ? 137.037 135.260 87.691  1.00 13.88 ? 310 TYR B CD1 1 
ATOM   5755 C CD2 . TYR B 2 310 ? 136.370 134.232 85.654  1.00 13.88 ? 310 TYR B CD2 1 
ATOM   5756 C CE1 . TYR B 2 310 ? 135.716 135.442 88.035  1.00 13.88 ? 310 TYR B CE1 1 
ATOM   5757 C CE2 . TYR B 2 310 ? 135.047 134.413 85.989  1.00 13.88 ? 310 TYR B CE2 1 
ATOM   5758 C CZ  . TYR B 2 310 ? 134.726 135.019 87.180  1.00 13.88 ? 310 TYR B CZ  1 
ATOM   5759 O OH  . TYR B 2 310 ? 133.406 135.200 87.517  1.00 13.88 ? 310 TYR B OH  1 
ATOM   5760 N N   . LEU B 2 311 ? 138.968 133.394 89.364  1.00 14.90 ? 311 LEU B N   1 
ATOM   5761 C CA  . LEU B 2 311 ? 138.648 132.363 90.350  1.00 14.90 ? 311 LEU B CA  1 
ATOM   5762 C C   . LEU B 2 311 ? 139.866 131.537 90.749  1.00 14.90 ? 311 LEU B C   1 
ATOM   5763 O O   . LEU B 2 311 ? 139.719 130.441 91.298  1.00 14.90 ? 311 LEU B O   1 
ATOM   5764 C CB  . LEU B 2 311 ? 137.530 131.440 89.855  1.00 14.90 ? 311 LEU B CB  1 
ATOM   5765 C CG  . LEU B 2 311 ? 136.116 131.794 90.318  1.00 14.90 ? 311 LEU B CG  1 
ATOM   5766 C CD1 . LEU B 2 311 ? 135.083 130.922 89.621  1.00 14.90 ? 311 LEU B CD1 1 
ATOM   5767 C CD2 . LEU B 2 311 ? 136.005 131.664 91.826  1.00 14.90 ? 311 LEU B CD2 1 
ATOM   5768 N N   . ASP B 2 312 ? 141.068 132.039 90.469  1.00 15.73 ? 312 ASP B N   1 
ATOM   5769 C CA  . ASP B 2 312 ? 142.340 131.406 90.809  1.00 15.73 ? 312 ASP B CA  1 
ATOM   5770 C C   . ASP B 2 312 ? 142.536 130.052 90.133  1.00 15.73 ? 312 ASP B C   1 
ATOM   5771 O O   . ASP B 2 312 ? 143.502 129.346 90.444  1.00 15.73 ? 312 ASP B O   1 
ATOM   5772 C CB  . ASP B 2 312 ? 142.499 131.258 92.327  1.00 15.73 ? 312 ASP B CB  1 
ATOM   5773 C CG  . ASP B 2 312 ? 142.460 132.591 93.048  1.00 15.73 ? 312 ASP B CG  1 
ATOM   5774 O OD1 . ASP B 2 312 ? 143.052 133.563 92.536  1.00 15.73 ? 312 ASP B OD1 1 
ATOM   5775 O OD2 . ASP B 2 312 ? 141.829 132.670 94.121  1.00 15.73 ? 312 ASP B OD2 1 
ATOM   5776 N N   . VAL B 2 313 ? 141.652 129.672 89.213  1.00 17.08 ? 313 VAL B N   1 
ATOM   5777 C CA  . VAL B 2 313 ? 141.753 128.384 88.541  1.00 17.08 ? 313 VAL B CA  1 
ATOM   5778 C C   . VAL B 2 313 ? 141.802 128.503 87.024  1.00 17.08 ? 313 VAL B C   1 
ATOM   5779 O O   . VAL B 2 313 ? 142.258 127.557 86.361  1.00 17.08 ? 313 VAL B O   1 
ATOM   5780 C CB  . VAL B 2 313 ? 140.596 127.449 88.956  1.00 17.08 ? 313 VAL B CB  1 
ATOM   5781 C CG1 . VAL B 2 313 ? 140.561 127.276 90.462  1.00 17.08 ? 313 VAL B CG1 1 
ATOM   5782 C CG2 . VAL B 2 313 ? 139.270 127.985 88.450  1.00 17.08 ? 313 VAL B CG2 1 
ATOM   5783 N N   . TYR B 2 314 ? 141.350 129.616 86.440  1.00 17.70 ? 314 TYR B N   1 
ATOM   5784 C CA  . TYR B 2 314 ? 141.282 129.713 84.986  1.00 17.70 ? 314 TYR B CA  1 
ATOM   5785 C C   . TYR B 2 314 ? 142.661 129.869 84.358  1.00 17.70 ? 314 TYR B C   1 
ATOM   5786 O O   . TYR B 2 314 ? 142.901 129.345 83.264  1.00 17.70 ? 314 TYR B O   1 
ATOM   5787 C CB  . TYR B 2 314 ? 140.384 130.880 84.578  1.00 17.70 ? 314 TYR B CB  1 
ATOM   5788 C CG  . TYR B 2 314 ? 138.906 130.561 84.606  1.00 17.70 ? 314 TYR B CG  1 
ATOM   5789 C CD1 . TYR B 2 314 ? 138.286 130.146 85.776  1.00 17.70 ? 314 TYR B CD1 1 
ATOM   5790 C CD2 . TYR B 2 314 ? 138.129 130.682 83.461  1.00 17.70 ? 314 TYR B CD2 1 
ATOM   5791 C CE1 . TYR B 2 314 ? 136.938 129.858 85.807  1.00 17.70 ? 314 TYR B CE1 1 
ATOM   5792 C CE2 . TYR B 2 314 ? 136.779 130.395 83.483  1.00 17.70 ? 314 TYR B CE2 1 
ATOM   5793 C CZ  . TYR B 2 314 ? 136.189 129.984 84.658  1.00 17.70 ? 314 TYR B CZ  1 
ATOM   5794 O OH  . TYR B 2 314 ? 134.845 129.697 84.686  1.00 17.70 ? 314 TYR B OH  1 
ATOM   5795 N N   . ASN B 2 315 ? 143.571 130.579 85.027  1.00 16.72 ? 315 ASN B N   1 
ATOM   5796 C CA  . ASN B 2 315 ? 144.912 130.846 84.505  1.00 16.72 ? 315 ASN B CA  1 
ATOM   5797 C C   . ASN B 2 315 ? 144.842 131.504 83.128  1.00 16.72 ? 315 ASN B C   1 
ATOM   5798 O O   . ASN B 2 315 ? 145.414 131.022 82.149  1.00 16.72 ? 315 ASN B O   1 
ATOM   5799 C CB  . ASN B 2 315 ? 145.754 129.568 84.464  1.00 16.72 ? 315 ASN B CB  1 
ATOM   5800 C CG  . ASN B 2 315 ? 147.238 129.852 84.333  1.00 16.72 ? 315 ASN B CG  1 
ATOM   5801 O OD1 . ASN B 2 315 ? 147.659 131.007 84.284  1.00 16.72 ? 315 ASN B OD1 1 
ATOM   5802 N ND2 . ASN B 2 315 ? 148.038 128.795 84.273  1.00 16.72 ? 315 ASN B ND2 1 
ATOM   5803 N N   . ASN B 2 316 ? 144.125 132.621 83.060  1.00 16.00 ? 316 ASN B N   1 
ATOM   5804 C CA  . ASN B 2 316 ? 143.913 133.355 81.820  1.00 16.00 ? 316 ASN B CA  1 
ATOM   5805 C C   . ASN B 2 316 ? 144.702 134.654 81.854  1.00 16.00 ? 316 ASN B C   1 
ATOM   5806 O O   . ASN B 2 316 ? 144.665 135.380 82.852  1.00 16.00 ? 316 ASN B O   1 
ATOM   5807 C CB  . ASN B 2 316 ? 142.428 133.653 81.608  1.00 16.00 ? 316 ASN B CB  1 
ATOM   5808 C CG  . ASN B 2 316 ? 141.778 134.278 82.826  1.00 16.00 ? 316 ASN B CG  1 
ATOM   5809 O OD1 . ASN B 2 316 ? 142.355 134.300 83.912  1.00 16.00 ? 316 ASN B OD1 1 
ATOM   5810 N ND2 . ASN B 2 316 ? 140.569 134.794 82.649  1.00 16.00 ? 316 ASN B ND2 1 
ATOM   5811 N N   . LYS B 2 317 ? 145.414 134.942 80.770  1.00 18.11 ? 317 LYS B N   1 
ATOM   5812 C CA  . LYS B 2 317 ? 146.110 136.215 80.641  1.00 18.11 ? 317 LYS B CA  1 
ATOM   5813 C C   . LYS B 2 317 ? 145.120 137.265 80.152  1.00 18.11 ? 317 LYS B C   1 
ATOM   5814 O O   . LYS B 2 317 ? 144.525 137.112 79.080  1.00 18.11 ? 317 LYS B O   1 
ATOM   5815 C CB  . LYS B 2 317 ? 147.293 136.092 79.684  1.00 18.11 ? 317 LYS B CB  1 
ATOM   5816 C CG  . LYS B 2 317 ? 148.242 134.943 79.998  1.00 18.11 ? 317 LYS B CG  1 
ATOM   5817 C CD  . LYS B 2 317 ? 148.568 134.863 81.483  1.00 18.11 ? 317 LYS B CD  1 
ATOM   5818 C CE  . LYS B 2 317 ? 149.513 135.971 81.913  1.00 18.11 ? 317 LYS B CE  1 
ATOM   5819 N NZ  . LYS B 2 317 ? 149.889 135.846 83.348  1.00 18.11 ? 317 LYS B NZ  1 
ATOM   5820 N N   . ALA B 2 318 ? 144.941 138.324 80.934  1.00 15.85 ? 318 ALA B N   1 
ATOM   5821 C CA  . ALA B 2 318 ? 143.923 139.313 80.622  1.00 15.85 ? 318 ALA B CA  1 
ATOM   5822 C C   . ALA B 2 318 ? 144.351 140.165 79.428  1.00 15.85 ? 318 ALA B C   1 
ATOM   5823 O O   . ALA B 2 318 ? 145.486 140.096 78.954  1.00 15.85 ? 318 ALA B O   1 
ATOM   5824 C CB  . ALA B 2 318 ? 143.649 140.192 81.838  1.00 15.85 ? 318 ALA B CB  1 
ATOM   5825 N N   . ALA B 2 319 ? 143.422 140.986 78.942  1.00 14.12 ? 319 ALA B N   1 
ATOM   5826 C CA  . ALA B 2 319 ? 143.684 141.843 77.796  1.00 14.12 ? 319 ALA B CA  1 
ATOM   5827 C C   . ALA B 2 319 ? 143.078 143.218 78.025  1.00 14.12 ? 319 ALA B C   1 
ATOM   5828 O O   . ALA B 2 319 ? 142.058 143.360 78.703  1.00 14.12 ? 319 ALA B O   1 
ATOM   5829 C CB  . ALA B 2 319 ? 143.126 141.238 76.503  1.00 14.12 ? 319 ALA B CB  1 
ATOM   5830 N N   . VAL B 2 320 ? 143.725 144.233 77.456  1.00 13.22 ? 320 VAL B N   1 
ATOM   5831 C CA  . VAL B 2 320 ? 143.245 145.610 77.517  1.00 13.22 ? 320 VAL B CA  1 
ATOM   5832 C C   . VAL B 2 320 ? 143.469 146.254 76.156  1.00 13.22 ? 320 VAL B C   1 
ATOM   5833 O O   . VAL B 2 320 ? 144.562 146.147 75.590  1.00 13.22 ? 320 VAL B O   1 
ATOM   5834 C CB  . VAL B 2 320 ? 143.958 146.409 78.625  1.00 13.22 ? 320 VAL B CB  1 
ATOM   5835 C CG1 . VAL B 2 320 ? 143.766 147.890 78.418  1.00 13.22 ? 320 VAL B CG1 1 
ATOM   5836 C CG2 . VAL B 2 320 ? 143.441 145.997 79.991  1.00 13.22 ? 320 VAL B CG2 1 
ATOM   5837 N N   . LEU B 2 321 ? 142.450 146.925 75.628  1.00 14.00 ? 321 LEU B N   1 
ATOM   5838 C CA  . LEU B 2 321 ? 142.537 147.482 74.286  1.00 14.00 ? 321 LEU B CA  1 
ATOM   5839 C C   . LEU B 2 321 ? 142.815 148.978 74.336  1.00 14.00 ? 321 LEU B C   1 
ATOM   5840 O O   . LEU B 2 321 ? 142.403 149.673 75.264  1.00 14.00 ? 321 LEU B O   1 
ATOM   5841 C CB  . LEU B 2 321 ? 141.254 147.222 73.490  1.00 14.00 ? 321 LEU B CB  1 
ATOM   5842 C CG  . LEU B 2 321 ? 140.981 145.814 72.947  1.00 14.00 ? 321 LEU B CG  1 
ATOM   5843 C CD1 . LEU B 2 321 ? 140.845 144.765 74.041  1.00 14.00 ? 321 LEU B CD1 1 
ATOM   5844 C CD2 . LEU B 2 321 ? 139.744 145.823 72.062  1.00 14.00 ? 321 LEU B CD2 1 
ATOM   5845 N N   . LYS B 2 322 ? 143.528 149.468 73.323  1.00 16.68 ? 322 LYS B N   1 
ATOM   5846 C CA  . LYS B 2 322 ? 143.800 150.891 73.174  1.00 16.68 ? 322 LYS B CA  1 
ATOM   5847 C C   . LYS B 2 322 ? 143.428 151.339 71.769  1.00 16.68 ? 322 LYS B C   1 
ATOM   5848 O O   . LYS B 2 322 ? 143.715 150.639 70.786  1.00 16.68 ? 322 LYS B O   1 
ATOM   5849 C CB  . LYS B 2 322 ? 145.269 151.225 73.460  1.00 16.68 ? 322 LYS B CB  1 
ATOM   5850 C CG  . LYS B 2 322 ? 145.631 151.325 74.932  1.00 16.68 ? 322 LYS B CG  1 
ATOM   5851 C CD  . LYS B 2 322 ? 146.997 151.974 75.102  1.00 16.68 ? 322 LYS B CD  1 
ATOM   5852 C CE  . LYS B 2 322 ? 147.327 152.222 76.564  1.00 16.68 ? 322 LYS B CE  1 
ATOM   5853 N NZ  . LYS B 2 322 ? 146.119 152.186 77.427  1.00 16.68 ? 322 LYS B NZ  1 
ATOM   5854 N N   . TYR B 2 323 ? 142.786 152.505 71.686  1.00 19.07 ? 323 TYR B N   1 
ATOM   5855 C CA  . TYR B 2 323 ? 142.401 153.137 70.429  1.00 19.07 ? 323 TYR B CA  1 
ATOM   5856 C C   . TYR B 2 323 ? 143.068 154.505 70.380  1.00 19.07 ? 323 TYR B C   1 
ATOM   5857 O O   . TYR B 2 323 ? 142.673 155.418 71.115  1.00 19.07 ? 323 TYR B O   1 
ATOM   5858 C CB  . TYR B 2 323 ? 140.883 153.271 70.327  1.00 19.07 ? 323 TYR B CB  1 
ATOM   5859 C CG  . TYR B 2 323 ? 140.381 153.607 68.941  1.00 19.07 ? 323 TYR B CG  1 
ATOM   5860 C CD1 . TYR B 2 323 ? 139.058 153.973 68.732  1.00 19.07 ? 323 TYR B CD1 1 
ATOM   5861 C CD2 . TYR B 2 323 ? 141.219 153.529 67.838  1.00 19.07 ? 323 TYR B CD2 1 
ATOM   5862 C CE1 . TYR B 2 323 ? 138.591 154.274 67.467  1.00 19.07 ? 323 TYR B CE1 1 
ATOM   5863 C CE2 . TYR B 2 323 ? 140.762 153.824 66.572  1.00 19.07 ? 323 TYR B CE2 1 
ATOM   5864 C CZ  . TYR B 2 323 ? 139.448 154.197 66.391  1.00 19.07 ? 323 TYR B CZ  1 
ATOM   5865 O OH  . TYR B 2 323 ? 138.993 154.492 65.127  1.00 19.07 ? 323 TYR B OH  1 
ATOM   5866 N N   . GLU B 2 324 ? 144.073 154.650 69.519  1.00 20.38 ? 324 GLU B N   1 
ATOM   5867 C CA  . GLU B 2 324 ? 144.795 155.907 69.392  1.00 20.38 ? 324 GLU B CA  1 
ATOM   5868 C C   . GLU B 2 324 ? 145.314 156.042 67.969  1.00 20.38 ? 324 GLU B C   1 
ATOM   5869 O O   . GLU B 2 324 ? 145.773 155.062 67.377  1.00 20.38 ? 324 GLU B O   1 
ATOM   5870 C CB  . GLU B 2 324 ? 145.957 155.990 70.389  1.00 20.38 ? 324 GLU B CB  1 
ATOM   5871 N N   . ASN B 2 325 ? 145.243 157.262 67.436  1.00 21.58 ? 325 ASN B N   1 
ATOM   5872 C CA  . ASN B 2 325 ? 145.688 157.559 66.073  1.00 21.58 ? 325 ASN B CA  1 
ATOM   5873 C C   . ASN B 2 325 ? 144.994 156.658 65.055  1.00 21.58 ? 325 ASN B C   1 
ATOM   5874 O O   . ASN B 2 325 ? 145.603 156.188 64.091  1.00 21.58 ? 325 ASN B O   1 
ATOM   5875 C CB  . ASN B 2 325 ? 147.209 157.445 65.954  1.00 21.58 ? 325 ASN B CB  1 
ATOM   5876 C CG  . ASN B 2 325 ? 147.776 158.343 64.873  1.00 21.58 ? 325 ASN B CG  1 
ATOM   5877 O OD1 . ASN B 2 325 ? 147.058 158.777 63.972  1.00 21.58 ? 325 ASN B OD1 1 
ATOM   5878 N ND2 . ASN B 2 325 ? 149.070 158.628 64.959  1.00 21.58 ? 325 ASN B ND2 1 
ATOM   5879 N N   . ASN B 2 326 ? 143.698 156.422 65.274  1.00 21.73 ? 326 ASN B N   1 
ATOM   5880 C CA  . ASN B 2 326 ? 142.887 155.561 64.411  1.00 21.73 ? 326 ASN B CA  1 
ATOM   5881 C C   . ASN B 2 326 ? 143.517 154.172 64.289  1.00 21.73 ? 326 ASN B C   1 
ATOM   5882 O O   . ASN B 2 326 ? 143.622 153.605 63.200  1.00 21.73 ? 326 ASN B O   1 
ATOM   5883 C CB  . ASN B 2 326 ? 142.678 156.206 63.035  1.00 21.73 ? 326 ASN B CB  1 
ATOM   5884 C CG  . ASN B 2 326 ? 141.667 155.459 62.174  1.00 21.73 ? 326 ASN B CG  1 
ATOM   5885 O OD1 . ASN B 2 326 ? 141.120 154.432 62.577  1.00 21.73 ? 326 ASN B OD1 1 
ATOM   5886 N ND2 . ASN B 2 326 ? 141.419 155.978 60.977  1.00 21.73 ? 326 ASN B ND2 1 
ATOM   5887 N N   . VAL B 2 327 ? 143.969 153.630 65.419  1.00 18.41 ? 327 VAL B N   1 
ATOM   5888 C CA  . VAL B 2 327 ? 144.599 152.316 65.470  1.00 18.41 ? 327 VAL B CA  1 
ATOM   5889 C C   . VAL B 2 327 ? 144.036 151.552 66.660  1.00 18.41 ? 327 VAL B C   1 
ATOM   5890 O O   . VAL B 2 327 ? 144.010 152.071 67.781  1.00 18.41 ? 327 VAL B O   1 
ATOM   5891 C CB  . VAL B 2 327 ? 146.134 152.418 65.573  1.00 18.41 ? 327 VAL B CB  1 
ATOM   5892 C CG1 . VAL B 2 327 ? 146.748 151.046 65.820  1.00 18.41 ? 327 VAL B CG1 1 
ATOM   5893 C CG2 . VAL B 2 327 ? 146.715 153.046 64.316  1.00 18.41 ? 327 VAL B CG2 1 
ATOM   5894 N N   . MET B 2 328 ? 143.594 150.321 66.415  1.00 19.62 ? 328 MET B N   1 
ATOM   5895 C CA  . MET B 2 328 ? 143.150 149.407 67.459  1.00 19.62 ? 328 MET B CA  1 
ATOM   5896 C C   . MET B 2 328 ? 144.283 148.448 67.793  1.00 19.62 ? 328 MET B C   1 
ATOM   5897 O O   . MET B 2 328 ? 144.801 147.768 66.902  1.00 19.62 ? 328 MET B O   1 
ATOM   5898 C CB  . MET B 2 328 ? 141.923 148.614 67.002  1.00 19.62 ? 328 MET B CB  1 
ATOM   5899 C CG  . MET B 2 328 ? 141.217 147.826 68.100  1.00 19.62 ? 328 MET B CG  1 
ATOM   5900 S SD  . MET B 2 328 ? 140.946 148.727 69.635  1.00 19.62 ? 328 MET B SD  1 
ATOM   5901 C CE  . MET B 2 328 ? 139.987 150.113 69.033  1.00 19.62 ? 328 MET B CE  1 
ATOM   5902 N N   . ASN B 2 329 ? 144.667 148.387 69.068  1.00 17.20 ? 329 ASN B N   1 
ATOM   5903 C CA  . ASN B 2 329 ? 145.678 147.417 69.471  1.00 17.20 ? 329 ASN B CA  1 
ATOM   5904 C C   . ASN B 2 329 ? 145.329 146.822 70.827  1.00 17.20 ? 329 ASN B C   1 
ATOM   5905 O O   . ASN B 2 329 ? 144.555 147.404 71.590  1.00 17.20 ? 329 ASN B O   1 
ATOM   5906 C CB  . ASN B 2 329 ? 147.087 148.036 69.483  1.00 17.20 ? 329 ASN B CB  1 
ATOM   5907 C CG  . ASN B 2 329 ? 147.208 149.213 70.424  1.00 17.20 ? 329 ASN B CG  1 
ATOM   5908 O OD1 . ASN B 2 329 ? 146.278 149.538 71.154  1.00 17.20 ? 329 ASN B OD1 1 
ATOM   5909 N ND2 . ASN B 2 329 ? 148.366 149.861 70.410  1.00 17.20 ? 329 ASN B ND2 1 
ATOM   5910 N N   . ILE B 2 330 ? 145.884 145.645 71.106  1.00 17.54 ? 330 ILE B N   1 
ATOM   5911 C CA  . ILE B 2 330 ? 145.563 144.872 72.300  1.00 17.54 ? 330 ILE B CA  1 
ATOM   5912 C C   . ILE B 2 330 ? 146.853 144.597 73.058  1.00 17.54 ? 330 ILE B C   1 
ATOM   5913 O O   . ILE B 2 330 ? 147.848 144.166 72.464  1.00 17.54 ? 330 ILE B O   1 
ATOM   5914 C CB  . ILE B 2 330 ? 144.849 143.555 71.948  1.00 17.54 ? 330 ILE B CB  1 
ATOM   5915 C CG1 . ILE B 2 330 ? 143.506 143.821 71.263  1.00 17.54 ? 330 ILE B CG1 1 
ATOM   5916 C CG2 . ILE B 2 330 ? 144.649 142.708 73.192  1.00 17.54 ? 330 ILE B CG2 1 
ATOM   5917 C CD1 . ILE B 2 330 ? 143.590 143.946 69.755  1.00 17.54 ? 330 ILE B CD1 1 
ATOM   5918 N N   . ARG B 2 331 ? 146.837 144.842 74.365  1.00 18.57 ? 331 ARG B N   1 
ATOM   5919 C CA  . ARG B 2 331 ? 147.971 144.566 75.234  1.00 18.57 ? 331 ARG B CA  1 
ATOM   5920 C C   . ARG B 2 331 ? 147.588 143.484 76.234  1.00 18.57 ? 331 ARG B C   1 
ATOM   5921 O O   . ARG B 2 331 ? 146.526 143.561 76.865  1.00 18.57 ? 331 ARG B O   1 
ATOM   5922 C CB  . ARG B 2 331 ? 148.421 145.830 75.965  1.00 18.57 ? 331 ARG B CB  1 
ATOM   5923 C CG  . ARG B 2 331 ? 149.668 145.643 76.803  1.00 18.57 ? 331 ARG B CG  1 
ATOM   5924 C CD  . ARG B 2 331 ? 150.072 146.945 77.460  1.00 18.57 ? 331 ARG B CD  1 
ATOM   5925 N NE  . ARG B 2 331 ? 150.448 147.954 76.476  1.00 18.57 ? 331 ARG B NE  1 
ATOM   5926 C CZ  . ARG B 2 331 ? 149.752 149.061 76.246  1.00 18.57 ? 331 ARG B CZ  1 
ATOM   5927 N NH1 . ARG B 2 331 ? 150.162 149.931 75.333  1.00 18.57 ? 331 ARG B NH1 1 
ATOM   5928 N NH2 . ARG B 2 331 ? 148.642 149.296 76.930  1.00 18.57 ? 331 ARG B NH2 1 
ATOM   5929 N N   . GLN B 2 332 ? 148.450 142.481 76.371  1.00 19.88 ? 332 GLN B N   1 
ATOM   5930 C CA  . GLN B 2 332 ? 148.213 141.395 77.306  1.00 19.88 ? 332 GLN B CA  1 
ATOM   5931 C C   . GLN B 2 332 ? 148.503 141.850 78.735  1.00 19.88 ? 332 GLN B C   1 
ATOM   5932 O O   . GLN B 2 332 ? 149.070 142.918 78.979  1.00 19.88 ? 332 GLN B O   1 
ATOM   5933 C CB  . GLN B 2 332 ? 149.061 140.178 76.942  1.00 19.88 ? 332 GLN B CB  1 
ATOM   5934 C CG  . GLN B 2 332 ? 148.639 139.505 75.645  1.00 19.88 ? 332 GLN B CG  1 
ATOM   5935 C CD  . GLN B 2 332 ? 147.576 138.444 75.857  1.00 19.88 ? 332 GLN B CD  1 
ATOM   5936 O OE1 . GLN B 2 332 ? 147.135 138.206 76.981  1.00 19.88 ? 332 GLN B OE1 1 
ATOM   5937 N NE2 . GLN B 2 332 ? 147.155 137.803 74.772  1.00 19.88 ? 332 GLN B NE2 1 
ATOM   5938 N N   . PHE B 2 333 ? 148.100 141.015 79.689  1.00 17.19 ? 333 PHE B N   1 
ATOM   5939 C CA  . PHE B 2 333 ? 148.086 141.404 81.091  1.00 17.19 ? 333 PHE B CA  1 
ATOM   5940 C C   . PHE B 2 333 ? 148.297 140.172 81.958  1.00 17.19 ? 333 PHE B C   1 
ATOM   5941 O O   . PHE B 2 333 ? 147.623 139.155 81.766  1.00 17.19 ? 333 PHE B O   1 
ATOM   5942 C CB  . PHE B 2 333 ? 146.757 142.087 81.427  1.00 17.19 ? 333 PHE B CB  1 
ATOM   5943 C CG  . PHE B 2 333 ? 146.703 142.675 82.797  1.00 17.19 ? 333 PHE B CG  1 
ATOM   5944 C CD1 . PHE B 2 333 ? 147.601 143.649 83.178  1.00 17.19 ? 333 PHE B CD1 1 
ATOM   5945 C CD2 . PHE B 2 333 ? 145.745 142.260 83.702  1.00 17.19 ? 333 PHE B CD2 1 
ATOM   5946 C CE1 . PHE B 2 333 ? 147.548 144.190 84.437  1.00 17.19 ? 333 PHE B CE1 1 
ATOM   5947 C CE2 . PHE B 2 333 ? 145.686 142.798 84.962  1.00 17.19 ? 333 PHE B CE2 1 
ATOM   5948 C CZ  . PHE B 2 333 ? 146.589 143.762 85.333  1.00 17.19 ? 333 PHE B CZ  1 
ATOM   5949 N N   . ASN B 2 334 ? 149.217 140.275 82.915  1.00 16.10 ? 334 ASN B N   1 
ATOM   5950 C CA  . ASN B 2 334 ? 149.619 139.163 83.760  1.00 16.10 ? 334 ASN B CA  1 
ATOM   5951 C C   . ASN B 2 334 ? 148.952 139.263 85.132  1.00 16.10 ? 334 ASN B C   1 
ATOM   5952 O O   . ASN B 2 334 ? 148.096 140.118 85.374  1.00 16.10 ? 334 ASN B O   1 
ATOM   5953 C CB  . ASN B 2 334 ? 151.144 139.125 83.874  1.00 16.10 ? 334 ASN B CB  1 
ATOM   5954 N N   . CYS B 2 335 ? 149.354 138.382 86.046  1.00 13.62 ? 335 CYS B N   1 
ATOM   5955 C CA  . CYS B 2 335 ? 148.760 138.274 87.369  1.00 13.62 ? 335 CYS B CA  1 
ATOM   5956 C C   . CYS B 2 335 ? 149.608 139.015 88.404  1.00 13.62 ? 335 CYS B C   1 
ATOM   5957 O O   . CYS B 2 335 ? 150.617 139.648 88.086  1.00 13.62 ? 335 CYS B O   1 
ATOM   5958 C CB  . CYS B 2 335 ? 148.592 136.802 87.750  1.00 13.62 ? 335 CYS B CB  1 
ATOM   5959 S SG  . CYS B 2 335 ? 148.080 136.517 89.458  1.00 13.62 ? 335 CYS B SG  1 
ATOM   5960 N N   . SER B 2 336 ? 149.182 138.932 89.664  1.00 10.57 ? 336 SER B N   1 
ATOM   5961 C CA  . SER B 2 336 ? 149.881 139.565 90.775  1.00 10.57 ? 336 SER B CA  1 
ATOM   5962 C C   . SER B 2 336 ? 149.429 138.906 92.068  1.00 10.57 ? 336 SER B C   1 
ATOM   5963 O O   . SER B 2 336 ? 148.263 138.511 92.180  1.00 10.57 ? 336 SER B O   1 
ATOM   5964 C CB  . SER B 2 336 ? 149.605 141.074 90.819  1.00 10.57 ? 336 SER B CB  1 
ATOM   5965 O OG  . SER B 2 336 ? 150.304 141.746 89.787  1.00 10.57 ? 336 SER B OG  1 
ATOM   5966 N N   . PRO B 2 337 ? 150.313 138.773 93.055  1.00 9.80  ? 337 PRO B N   1 
ATOM   5967 C CA  . PRO B 2 337 ? 149.939 138.076 94.290  1.00 9.80  ? 337 PRO B CA  1 
ATOM   5968 C C   . PRO B 2 337 ? 148.925 138.859 95.107  1.00 9.80  ? 337 PRO B C   1 
ATOM   5969 O O   . PRO B 2 337 ? 148.849 140.087 95.041  1.00 9.80  ? 337 PRO B O   1 
ATOM   5970 C CB  . PRO B 2 337 ? 151.269 137.947 95.039  1.00 9.80  ? 337 PRO B CB  1 
ATOM   5971 C CG  . PRO B 2 337 ? 152.096 139.070 94.527  1.00 9.80  ? 337 PRO B CG  1 
ATOM   5972 C CD  . PRO B 2 337 ? 151.698 139.269 93.093  1.00 9.80  ? 337 PRO B CD  1 
ATOM   5973 N N   . HIS B 2 338 ? 148.144 138.124 95.888  1.00 6.76  ? 338 HIS B N   1 
ATOM   5974 C CA  . HIS B 2 338 ? 147.127 138.680 96.765  1.00 6.76  ? 338 HIS B CA  1 
ATOM   5975 C C   . HIS B 2 338 ? 147.134 137.905 98.072  1.00 6.76  ? 338 HIS B C   1 
ATOM   5976 O O   . HIS B 2 338 ? 147.576 136.752 98.113  1.00 6.76  ? 338 HIS B O   1 
ATOM   5977 C CB  . HIS B 2 338 ? 145.735 138.619 96.122  1.00 6.76  ? 338 HIS B CB  1 
ATOM   5978 C CG  . HIS B 2 338 ? 145.325 137.244 95.699  1.00 6.76  ? 338 HIS B CG  1 
ATOM   5979 N ND1 . HIS B 2 338 ? 144.744 136.341 96.563  1.00 6.76  ? 338 HIS B ND1 1 
ATOM   5980 C CD2 . HIS B 2 338 ? 145.410 136.616 94.502  1.00 6.76  ? 338 HIS B CD2 1 
ATOM   5981 C CE1 . HIS B 2 338 ? 144.491 135.217 95.918  1.00 6.76  ? 338 HIS B CE1 1 
ATOM   5982 N NE2 . HIS B 2 338 ? 144.885 135.357 94.666  1.00 6.76  ? 338 HIS B NE2 1 
ATOM   5983 N N   . PRO B 2 339 ? 146.655 138.512 99.160  1.00 5.57  ? 339 PRO B N   1 
ATOM   5984 C CA  . PRO B 2 339 ? 146.617 137.803 100.448 1.00 5.57  ? 339 PRO B CA  1 
ATOM   5985 C C   . PRO B 2 339 ? 145.583 136.690 100.490 1.00 5.57  ? 339 PRO B C   1 
ATOM   5986 O O   . PRO B 2 339 ? 144.952 136.383 99.475  1.00 5.57  ? 339 PRO B O   1 
ATOM   5987 C CB  . PRO B 2 339 ? 146.276 138.913 101.448 1.00 5.57  ? 339 PRO B CB  1 
ATOM   5988 C CG  . PRO B 2 339 ? 146.617 140.183 100.749 1.00 5.57  ? 339 PRO B CG  1 
ATOM   5989 C CD  . PRO B 2 339 ? 146.320 139.934 99.313  1.00 5.57  ? 339 PRO B CD  1 
ATOM   5990 N N   . TYR B 2 340 ? 145.406 136.072 101.655 1.00 3.68  ? 340 TYR B N   1 
ATOM   5991 C CA  . TYR B 2 340 ? 144.510 134.936 101.812 1.00 3.68  ? 340 TYR B CA  1 
ATOM   5992 C C   . TYR B 2 340 ? 143.350 135.295 102.726 1.00 3.68  ? 340 TYR B C   1 
ATOM   5993 O O   . TYR B 2 340 ? 143.515 136.040 103.694 1.00 3.68  ? 340 TYR B O   1 
ATOM   5994 C CB  . TYR B 2 340 ? 145.250 133.727 102.379 1.00 3.68  ? 340 TYR B CB  1 
ATOM   5995 C CG  . TYR B 2 340 ? 144.459 132.439 102.331 1.00 3.68  ? 340 TYR B CG  1 
ATOM   5996 C CD1 . TYR B 2 340 ? 143.987 131.940 101.129 1.00 3.68  ? 340 TYR B CD1 1 
ATOM   5997 C CD2 . TYR B 2 340 ? 144.193 131.719 103.486 1.00 3.68  ? 340 TYR B CD2 1 
ATOM   5998 C CE1 . TYR B 2 340 ? 143.269 130.764 101.078 1.00 3.68  ? 340 TYR B CE1 1 
ATOM   5999 C CE2 . TYR B 2 340 ? 143.475 130.541 103.442 1.00 3.68  ? 340 TYR B CE2 1 
ATOM   6000 C CZ  . TYR B 2 340 ? 143.016 130.069 102.235 1.00 3.68  ? 340 TYR B CZ  1 
ATOM   6001 O OH  . TYR B 2 340 ? 142.299 128.898 102.179 1.00 3.68  ? 340 TYR B OH  1 
ATOM   6002 N N   . TRP B 2 341 ? 142.177 134.760 102.403 1.00 2.52  ? 341 TRP B N   1 
ATOM   6003 C CA  . TRP B 2 341 ? 140.976 134.894 103.212 1.00 2.52  ? 341 TRP B CA  1 
ATOM   6004 C C   . TRP B 2 341 ? 140.303 133.535 103.311 1.00 2.52  ? 341 TRP B C   1 
ATOM   6005 O O   . TRP B 2 341 ? 140.455 132.686 102.429 1.00 2.52  ? 341 TRP B O   1 
ATOM   6006 C CB  . TRP B 2 341 ? 139.988 135.894 102.610 1.00 2.52  ? 341 TRP B CB  1 
ATOM   6007 C CG  . TRP B 2 341 ? 140.079 137.286 103.135 1.00 2.52  ? 341 TRP B CG  1 
ATOM   6008 C CD1 . TRP B 2 341 ? 140.759 138.326 102.579 1.00 2.52  ? 341 TRP B CD1 1 
ATOM   6009 C CD2 . TRP B 2 341 ? 139.443 137.804 104.306 1.00 2.52  ? 341 TRP B CD2 1 
ATOM   6010 N NE1 . TRP B 2 341 ? 140.594 139.458 103.336 1.00 2.52  ? 341 TRP B NE1 1 
ATOM   6011 C CE2 . TRP B 2 341 ? 139.790 139.162 104.404 1.00 2.52  ? 341 TRP B CE2 1 
ATOM   6012 C CE3 . TRP B 2 341 ? 138.620 137.248 105.286 1.00 2.52  ? 341 TRP B CE3 1 
ATOM   6013 C CZ2 . TRP B 2 341 ? 139.342 139.972 105.439 1.00 2.52  ? 341 TRP B CZ2 1 
ATOM   6014 C CZ3 . TRP B 2 341 ? 138.176 138.055 106.313 1.00 2.52  ? 341 TRP B CZ3 1 
ATOM   6015 C CH2 . TRP B 2 341 ? 138.538 139.401 106.382 1.00 2.52  ? 341 TRP B CH2 1 
ATOM   6016 N N   . LEU B 2 342 ? 139.564 133.328 104.382 1.00 1.51  ? 342 LEU B N   1 
ATOM   6017 C CA  . LEU B 2 342 ? 138.823 132.082 104.454 1.00 1.51  ? 342 LEU B CA  1 
ATOM   6018 C C   . LEU B 2 342 ? 137.534 132.188 103.643 1.00 1.51  ? 342 LEU B C   1 
ATOM   6019 O O   . LEU B 2 342 ? 136.957 133.272 103.525 1.00 1.51  ? 342 LEU B O   1 
ATOM   6020 C CB  . LEU B 2 342 ? 138.492 131.739 105.899 1.00 1.51  ? 342 LEU B CB  1 
ATOM   6021 C CG  . LEU B 2 342 ? 139.584 131.065 106.718 1.00 1.51  ? 342 LEU B CG  1 
ATOM   6022 C CD1 . LEU B 2 342 ? 139.072 130.790 108.104 1.00 1.51  ? 342 LEU B CD1 1 
ATOM   6023 C CD2 . LEU B 2 342 ? 140.017 129.789 106.048 1.00 1.51  ? 342 LEU B CD2 1 
ATOM   6024 N N   . PRO B 2 343 ? 137.066 131.082 103.069 1.00 2.68  ? 343 PRO B N   1 
ATOM   6025 C CA  . PRO B 2 343 ? 135.776 131.112 102.374 1.00 2.68  ? 343 PRO B CA  1 
ATOM   6026 C C   . PRO B 2 343 ? 134.655 131.503 103.322 1.00 2.68  ? 343 PRO B C   1 
ATOM   6027 O O   . PRO B 2 343 ? 134.581 131.030 104.456 1.00 2.68  ? 343 PRO B O   1 
ATOM   6028 C CB  . PRO B 2 343 ? 135.612 129.676 101.866 1.00 2.68  ? 343 PRO B CB  1 
ATOM   6029 C CG  . PRO B 2 343 ? 136.554 128.866 102.688 1.00 2.68  ? 343 PRO B CG  1 
ATOM   6030 C CD  . PRO B 2 343 ? 137.707 129.763 102.973 1.00 2.68  ? 343 PRO B CD  1 
ATOM   6031 N N   . ASN B 2 344 ? 133.779 132.381 102.840 1.00 2.99  ? 344 ASN B N   1 
ATOM   6032 C CA  . ASN B 2 344 ? 132.690 132.969 103.617 1.00 2.99  ? 344 ASN B CA  1 
ATOM   6033 C C   . ASN B 2 344 ? 133.188 133.714 104.852 1.00 2.99  ? 344 ASN B C   1 
ATOM   6034 O O   . ASN B 2 344 ? 132.417 133.949 105.787 1.00 2.99  ? 344 ASN B O   1 
ATOM   6035 C CB  . ASN B 2 344 ? 131.651 131.919 104.020 1.00 2.99  ? 344 ASN B CB  1 
ATOM   6036 C CG  . ASN B 2 344 ? 130.276 132.515 104.220 1.00 2.99  ? 344 ASN B CG  1 
ATOM   6037 O OD1 . ASN B 2 344 ? 130.021 133.652 103.830 1.00 2.99  ? 344 ASN B OD1 1 
ATOM   6038 N ND2 . ASN B 2 344 ? 129.386 131.758 104.844 1.00 2.99  ? 344 ASN B ND2 1 
ATOM   6039 N N   . PHE B 2 345 ? 134.465 134.094 104.867 1.00 3.10  ? 345 PHE B N   1 
ATOM   6040 C CA  . PHE B 2 345 ? 135.017 135.006 105.868 1.00 3.10  ? 345 PHE B CA  1 
ATOM   6041 C C   . PHE B 2 345 ? 134.825 134.487 107.293 1.00 3.10  ? 345 PHE B C   1 
ATOM   6042 O O   . PHE B 2 345 ? 134.429 135.227 108.194 1.00 3.10  ? 345 PHE B O   1 
ATOM   6043 C CB  . PHE B 2 345 ? 134.404 136.400 105.729 1.00 3.10  ? 345 PHE B CB  1 
ATOM   6044 C CG  . PHE B 2 345 ? 134.499 136.973 104.352 1.00 3.10  ? 345 PHE B CG  1 
ATOM   6045 C CD1 . PHE B 2 345 ? 135.508 137.853 104.026 1.00 3.10  ? 345 PHE B CD1 1 
ATOM   6046 C CD2 . PHE B 2 345 ? 133.563 136.651 103.390 1.00 3.10  ? 345 PHE B CD2 1 
ATOM   6047 C CE1 . PHE B 2 345 ? 135.591 138.381 102.765 1.00 3.10  ? 345 PHE B CE1 1 
ATOM   6048 C CE2 . PHE B 2 345 ? 133.643 137.179 102.128 1.00 3.10  ? 345 PHE B CE2 1 
ATOM   6049 C CZ  . PHE B 2 345 ? 134.655 138.045 101.818 1.00 3.10  ? 345 PHE B CZ  1 
ATOM   6050 N N   . MET B 2 346 ? 135.104 133.205 107.502 1.00 3.19  ? 346 MET B N   1 
ATOM   6051 C CA  . MET B 2 346 ? 135.079 132.683 108.861 1.00 3.19  ? 346 MET B CA  1 
ATOM   6052 C C   . MET B 2 346 ? 136.281 133.162 109.660 1.00 3.19  ? 346 MET B C   1 
ATOM   6053 O O   . MET B 2 346 ? 137.398 133.257 109.147 1.00 3.19  ? 346 MET B O   1 
ATOM   6054 C CB  . MET B 2 346 ? 135.053 131.159 108.883 1.00 3.19  ? 346 MET B CB  1 
ATOM   6055 C CG  . MET B 2 346 ? 134.010 130.492 108.043 1.00 3.19  ? 346 MET B CG  1 
ATOM   6056 S SD  . MET B 2 346 ? 134.311 128.724 108.129 1.00 3.19  ? 346 MET B SD  1 
ATOM   6057 C CE  . MET B 2 346 ? 132.859 128.105 107.318 1.00 3.19  ? 346 MET B CE  1 
ATOM   6058 N N   . ASP B 2 347 ? 136.038 133.461 110.929 1.00 3.86  ? 347 ASP B N   1 
ATOM   6059 C CA  . ASP B 2 347 ? 137.095 133.681 111.900 1.00 3.86  ? 347 ASP B CA  1 
ATOM   6060 C C   . ASP B 2 347 ? 137.522 132.341 112.474 1.00 3.86  ? 347 ASP B C   1 
ATOM   6061 O O   . ASP B 2 347 ? 136.684 131.472 112.728 1.00 3.86  ? 347 ASP B O   1 
ATOM   6062 C CB  . ASP B 2 347 ? 136.607 134.613 113.006 1.00 3.86  ? 347 ASP B CB  1 
ATOM   6063 C CG  . ASP B 2 347 ? 135.216 134.258 113.484 1.00 3.86  ? 347 ASP B CG  1 
ATOM   6064 O OD1 . ASP B 2 347 ? 134.620 133.313 112.934 1.00 3.86  ? 347 ASP B OD1 1 
ATOM   6065 O OD2 . ASP B 2 347 ? 134.702 134.943 114.386 1.00 3.86  ? 347 ASP B OD2 1 
ATOM   6066 N N   . VAL B 2 348 ? 138.830 132.182 112.691 1.00 4.55  ? 348 VAL B N   1 
ATOM   6067 C CA  . VAL B 2 348 ? 139.398 130.863 112.952 1.00 4.55  ? 348 VAL B CA  1 
ATOM   6068 C C   . VAL B 2 348 ? 138.760 130.158 114.143 1.00 4.55  ? 348 VAL B C   1 
ATOM   6069 O O   . VAL B 2 348 ? 138.814 128.926 114.226 1.00 4.55  ? 348 VAL B O   1 
ATOM   6070 C CB  . VAL B 2 348 ? 140.918 130.978 113.136 1.00 4.55  ? 348 VAL B CB  1 
ATOM   6071 C CG1 . VAL B 2 348 ? 141.562 131.433 111.848 1.00 4.55  ? 348 VAL B CG1 1 
ATOM   6072 C CG2 . VAL B 2 348 ? 141.233 131.935 114.254 1.00 4.55  ? 348 VAL B CG2 1 
ATOM   6073 N N   . PHE B 2 349 ? 138.145 130.899 115.067 1.00 4.48  ? 349 PHE B N   1 
ATOM   6074 C CA  . PHE B 2 349 ? 137.393 130.250 116.137 1.00 4.48  ? 349 PHE B CA  1 
ATOM   6075 C C   . PHE B 2 349 ? 136.219 129.459 115.573 1.00 4.48  ? 349 PHE B C   1 
ATOM   6076 O O   . PHE B 2 349 ? 136.043 128.277 115.890 1.00 4.48  ? 349 PHE B O   1 
ATOM   6077 C CB  . PHE B 2 349 ? 136.905 131.287 117.146 1.00 4.48  ? 349 PHE B CB  1 
ATOM   6078 C CG  . PHE B 2 349 ? 138.009 132.068 117.796 1.00 4.48  ? 349 PHE B CG  1 
ATOM   6079 C CD1 . PHE B 2 349 ? 139.139 131.432 118.270 1.00 4.48  ? 349 PHE B CD1 1 
ATOM   6080 C CD2 . PHE B 2 349 ? 137.913 133.441 117.934 1.00 4.48  ? 349 PHE B CD2 1 
ATOM   6081 C CE1 . PHE B 2 349 ? 140.150 132.148 118.866 1.00 4.48  ? 349 PHE B CE1 1 
ATOM   6082 C CE2 . PHE B 2 349 ? 138.923 134.159 118.528 1.00 4.48  ? 349 PHE B CE2 1 
ATOM   6083 C CZ  . PHE B 2 349 ? 140.042 133.511 118.995 1.00 4.48  ? 349 PHE B CZ  1 
ATOM   6084 N N   . THR B 2 350 ? 135.405 130.097 114.725 1.00 6.02  ? 350 THR B N   1 
ATOM   6085 C CA  . THR B 2 350 ? 134.307 129.389 114.070 1.00 6.02  ? 350 THR B CA  1 
ATOM   6086 C C   . THR B 2 350 ? 134.827 128.355 113.082 1.00 6.02  ? 350 THR B C   1 
ATOM   6087 O O   . THR B 2 350 ? 134.150 127.361 112.805 1.00 6.02  ? 350 THR B O   1 
ATOM   6088 C CB  . THR B 2 350 ? 133.392 130.382 113.355 1.00 6.02  ? 350 THR B CB  1 
ATOM   6089 O OG1 . THR B 2 350 ? 133.021 131.426 114.261 1.00 6.02  ? 350 THR B OG1 1 
ATOM   6090 C CG2 . THR B 2 350 ? 132.134 129.694 112.862 1.00 6.02  ? 350 THR B CG2 1 
ATOM   6091 N N   . TRP B 2 351 ? 136.021 128.580 112.540 1.00 10.41 ? 351 TRP B N   1 
ATOM   6092 C CA  . TRP B 2 351 ? 136.629 127.617 111.632 1.00 10.41 ? 351 TRP B CA  1 
ATOM   6093 C C   . TRP B 2 351 ? 136.966 126.313 112.339 1.00 10.41 ? 351 TRP B C   1 
ATOM   6094 O O   . TRP B 2 351 ? 136.705 125.230 111.806 1.00 10.41 ? 351 TRP B O   1 
ATOM   6095 C CB  . TRP B 2 351 ? 137.885 128.224 111.024 1.00 10.41 ? 351 TRP B CB  1 
ATOM   6096 C CG  . TRP B 2 351 ? 138.484 127.442 109.927 1.00 10.41 ? 351 TRP B CG  1 
ATOM   6097 C CD1 . TRP B 2 351 ? 137.836 126.874 108.880 1.00 10.41 ? 351 TRP B CD1 1 
ATOM   6098 C CD2 . TRP B 2 351 ? 139.871 127.160 109.745 1.00 10.41 ? 351 TRP B CD2 1 
ATOM   6099 N NE1 . TRP B 2 351 ? 138.732 126.246 108.055 1.00 10.41 ? 351 TRP B NE1 1 
ATOM   6100 C CE2 . TRP B 2 351 ? 139.991 126.409 108.568 1.00 10.41 ? 351 TRP B CE2 1 
ATOM   6101 C CE3 . TRP B 2 351 ? 141.023 127.468 110.466 1.00 10.41 ? 351 TRP B CE3 1 
ATOM   6102 C CZ2 . TRP B 2 351 ? 141.215 125.959 108.098 1.00 10.41 ? 351 TRP B CZ2 1 
ATOM   6103 C CZ3 . TRP B 2 351 ? 142.234 127.022 109.997 1.00 10.41 ? 351 TRP B CZ3 1 
ATOM   6104 C CH2 . TRP B 2 351 ? 142.323 126.277 108.826 1.00 10.41 ? 351 TRP B CH2 1 
ATOM   6105 N N   . SER B 2 352 ? 137.542 126.391 113.541 1.00 6.49  ? 352 SER B N   1 
ATOM   6106 C CA  . SER B 2 352 ? 138.154 125.229 114.168 1.00 6.49  ? 352 SER B CA  1 
ATOM   6107 C C   . SER B 2 352 ? 137.398 124.676 115.364 1.00 6.49  ? 352 SER B C   1 
ATOM   6108 O O   . SER B 2 352 ? 137.747 123.590 115.831 1.00 6.49  ? 352 SER B O   1 
ATOM   6109 C CB  . SER B 2 352 ? 139.583 125.559 114.614 1.00 6.49  ? 352 SER B CB  1 
ATOM   6110 O OG  . SER B 2 352 ? 139.585 126.637 115.530 1.00 6.49  ? 352 SER B OG  1 
ATOM   6111 N N   . LEU B 2 353 ? 136.395 125.378 115.885 1.00 6.29  ? 353 LEU B N   1 
ATOM   6112 C CA  . LEU B 2 353 ? 135.732 124.895 117.093 1.00 6.29  ? 353 LEU B CA  1 
ATOM   6113 C C   . LEU B 2 353 ? 135.001 123.565 116.913 1.00 6.29  ? 353 LEU B C   1 
ATOM   6114 O O   . LEU B 2 353 ? 135.088 122.720 117.825 1.00 6.29  ? 353 LEU B O   1 
ATOM   6115 C CB  . LEU B 2 353 ? 134.789 125.979 117.622 1.00 6.29  ? 353 LEU B CB  1 
ATOM   6116 C CG  . LEU B 2 353 ? 134.185 125.655 118.981 1.00 6.29  ? 353 LEU B CG  1 
ATOM   6117 C CD1 . LEU B 2 353 ? 135.290 125.561 120.011 1.00 6.29  ? 353 LEU B CD1 1 
ATOM   6118 C CD2 . LEU B 2 353 ? 133.190 126.711 119.373 1.00 6.29  ? 353 LEU B CD2 1 
ATOM   6119 N N   . PRO B 2 354 ? 134.254 123.318 115.829 1.00 6.73  ? 354 PRO B N   1 
ATOM   6120 C CA  . PRO B 2 354 ? 133.637 121.991 115.664 1.00 6.73  ? 354 PRO B CA  1 
ATOM   6121 C C   . PRO B 2 354 ? 134.640 120.857 115.567 1.00 6.73  ? 354 PRO B C   1 
ATOM   6122 O O   . PRO B 2 354 ? 134.276 119.707 115.831 1.00 6.73  ? 354 PRO B O   1 
ATOM   6123 C CB  . PRO B 2 354 ? 132.832 122.137 114.367 1.00 6.73  ? 354 PRO B CB  1 
ATOM   6124 C CG  . PRO B 2 354 ? 132.561 123.585 114.259 1.00 6.73  ? 354 PRO B CG  1 
ATOM   6125 C CD  . PRO B 2 354 ? 133.783 124.257 114.796 1.00 6.73  ? 354 PRO B CD  1 
ATOM   6126 N N   . PHE B 2 355 ? 135.878 121.133 115.178 1.00 10.41 ? 355 PHE B N   1 
ATOM   6127 C CA  . PHE B 2 355 ? 136.935 120.135 115.198 1.00 10.41 ? 355 PHE B CA  1 
ATOM   6128 C C   . PHE B 2 355 ? 137.698 120.124 116.513 1.00 10.41 ? 355 PHE B C   1 
ATOM   6129 O O   . PHE B 2 355 ? 138.591 119.291 116.690 1.00 10.41 ? 355 PHE B O   1 
ATOM   6130 C CB  . PHE B 2 355 ? 137.903 120.377 114.047 1.00 10.41 ? 355 PHE B CB  1 
ATOM   6131 C CG  . PHE B 2 355 ? 138.824 119.235 113.779 1.00 10.41 ? 355 PHE B CG  1 
ATOM   6132 C CD1 . PHE B 2 355 ? 138.347 118.061 113.243 1.00 10.41 ? 355 PHE B CD1 1 
ATOM   6133 C CD2 . PHE B 2 355 ? 140.172 119.343 114.048 1.00 10.41 ? 355 PHE B CD2 1 
ATOM   6134 C CE1 . PHE B 2 355 ? 139.195 117.018 112.984 1.00 10.41 ? 355 PHE B CE1 1 
ATOM   6135 C CE2 . PHE B 2 355 ? 141.023 118.305 113.791 1.00 10.41 ? 355 PHE B CE2 1 
ATOM   6136 C CZ  . PHE B 2 355 ? 140.537 117.141 113.258 1.00 10.41 ? 355 PHE B CZ  1 
ATOM   6137 N N   . VAL B 2 356 ? 137.383 121.034 117.428 1.00 6.66  ? 356 VAL B N   1 
ATOM   6138 C CA  . VAL B 2 356 ? 137.887 120.956 118.794 1.00 6.66  ? 356 VAL B CA  1 
ATOM   6139 C C   . VAL B 2 356 ? 136.968 120.116 119.660 1.00 6.66  ? 356 VAL B C   1 
ATOM   6140 O O   . VAL B 2 356 ? 137.417 119.210 120.370 1.00 6.66  ? 356 VAL B O   1 
ATOM   6141 C CB  . VAL B 2 356 ? 138.052 122.373 119.380 1.00 6.66  ? 356 VAL B CB  1 
ATOM   6142 C CG1 . VAL B 2 356 ? 138.105 122.313 120.890 1.00 6.66  ? 356 VAL B CG1 1 
ATOM   6143 C CG2 . VAL B 2 356 ? 139.293 123.031 118.836 1.00 6.66  ? 356 VAL B CG2 1 
ATOM   6144 N N   . GLY B 2 357 ? 135.670 120.419 119.604 1.00 6.94  ? 357 GLY B N   1 
ATOM   6145 C CA  . GLY B 2 357 ? 134.714 119.688 120.418 1.00 6.94  ? 357 GLY B CA  1 
ATOM   6146 C C   . GLY B 2 357 ? 134.678 118.210 120.091 1.00 6.94  ? 357 GLY B C   1 
ATOM   6147 O O   . GLY B 2 357 ? 134.662 117.365 120.991 1.00 6.94  ? 357 GLY B O   1 
ATOM   6148 N N   . GLU B 2 358 ? 134.683 117.876 118.802 1.00 7.63  ? 358 GLU B N   1 
ATOM   6149 C CA  . GLU B 2 358 ? 134.640 116.475 118.407 1.00 7.63  ? 358 GLU B CA  1 
ATOM   6150 C C   . GLU B 2 358 ? 135.857 115.719 118.918 1.00 7.63  ? 358 GLU B C   1 
ATOM   6151 O O   . GLU B 2 358 ? 135.724 114.614 119.453 1.00 7.63  ? 358 GLU B O   1 
ATOM   6152 C CB  . GLU B 2 358 ? 134.533 116.359 116.889 1.00 7.63  ? 358 GLU B CB  1 
ATOM   6153 C CG  . GLU B 2 358 ? 134.948 115.006 116.340 1.00 7.63  ? 358 GLU B CG  1 
ATOM   6154 C CD  . GLU B 2 358 ? 134.982 114.980 114.825 1.00 7.63  ? 358 GLU B CD  1 
ATOM   6155 O OE1 . GLU B 2 358 ? 134.484 115.940 114.203 1.00 7.63  ? 358 GLU B OE1 1 
ATOM   6156 O OE2 . GLU B 2 358 ? 135.511 114.004 114.255 1.00 7.63  ? 358 GLU B OE2 1 
ATOM   6157 N N   . LYS B 2 359 ? 137.050 116.304 118.793 1.00 10.41 ? 359 LYS B N   1 
ATOM   6158 C CA  . LYS B 2 359 ? 138.253 115.584 119.202 1.00 10.41 ? 359 LYS B CA  1 
ATOM   6159 C C   . LYS B 2 359 ? 138.349 115.453 120.720 1.00 10.41 ? 359 LYS B C   1 
ATOM   6160 O O   . LYS B 2 359 ? 138.723 114.388 121.234 1.00 10.41 ? 359 LYS B O   1 
ATOM   6161 C CB  . LYS B 2 359 ? 139.491 116.266 118.634 1.00 10.41 ? 359 LYS B CB  1 
ATOM   6162 C CG  . LYS B 2 359 ? 139.660 116.048 117.151 1.00 10.41 ? 359 LYS B CG  1 
ATOM   6163 C CD  . LYS B 2 359 ? 139.798 114.576 116.830 1.00 10.41 ? 359 LYS B CD  1 
ATOM   6164 C CE  . LYS B 2 359 ? 140.009 114.346 115.349 1.00 10.41 ? 359 LYS B CE  1 
ATOM   6165 N NZ  . LYS B 2 359 ? 140.096 112.903 115.010 1.00 10.41 ? 359 LYS B NZ  1 
ATOM   6166 N N   . VAL B 2 360 ? 138.012 116.514 121.459 1.00 5.36  ? 360 VAL B N   1 
ATOM   6167 C CA  . VAL B 2 360 ? 138.040 116.427 122.919 1.00 5.36  ? 360 VAL B CA  1 
ATOM   6168 C C   . VAL B 2 360 ? 137.049 115.380 123.409 1.00 5.36  ? 360 VAL B C   1 
ATOM   6169 O O   . VAL B 2 360 ? 137.385 114.524 124.238 1.00 5.36  ? 360 VAL B O   1 
ATOM   6170 C CB  . VAL B 2 360 ? 137.769 117.803 123.551 1.00 5.36  ? 360 VAL B CB  1 
ATOM   6171 C CG1 . VAL B 2 360 ? 137.689 117.675 125.045 1.00 5.36  ? 360 VAL B CG1 1 
ATOM   6172 C CG2 . VAL B 2 360 ? 138.878 118.767 123.192 1.00 5.36  ? 360 VAL B CG2 1 
ATOM   6173 N N   . THR B 2 361 ? 135.815 115.423 122.899 1.00 3.16  ? 361 THR B N   1 
ATOM   6174 C CA  . THR B 2 361 ? 134.818 114.450 123.328 1.00 3.16  ? 361 THR B CA  1 
ATOM   6175 C C   . THR B 2 361 ? 135.212 113.034 122.929 1.00 3.16  ? 361 THR B C   1 
ATOM   6176 O O   . THR B 2 361 ? 134.978 112.088 123.687 1.00 3.16  ? 361 THR B O   1 
ATOM   6177 C CB  . THR B 2 361 ? 133.450 114.813 122.763 1.00 3.16  ? 361 THR B CB  1 
ATOM   6178 O OG1 . THR B 2 361 ? 133.073 116.109 123.241 1.00 3.16  ? 361 THR B OG1 1 
ATOM   6179 C CG2 . THR B 2 361 ? 132.411 113.799 123.191 1.00 3.16  ? 361 THR B CG2 1 
ATOM   6180 N N   . GLU B 2 362 ? 135.819 112.862 121.751 1.00 3.93  ? 362 GLU B N   1 
ATOM   6181 C CA  . GLU B 2 362 ? 136.275 111.534 121.357 1.00 3.93  ? 362 GLU B CA  1 
ATOM   6182 C C   . GLU B 2 362 ? 137.323 111.007 122.325 1.00 3.93  ? 362 GLU B C   1 
ATOM   6183 O O   . GLU B 2 362 ? 137.236 109.861 122.786 1.00 3.93  ? 362 GLU B O   1 
ATOM   6184 C CB  . GLU B 2 362 ? 136.828 111.559 119.934 1.00 3.93  ? 362 GLU B CB  1 
ATOM   6185 C CG  . GLU B 2 362 ? 137.893 110.503 119.684 1.00 3.93  ? 362 GLU B CG  1 
ATOM   6186 C CD  . GLU B 2 362 ? 138.323 110.429 118.235 1.00 3.93  ? 362 GLU B CD  1 
ATOM   6187 O OE1 . GLU B 2 362 ? 137.573 110.916 117.364 1.00 3.93  ? 362 GLU B OE1 1 
ATOM   6188 O OE2 . GLU B 2 362 ? 139.418 109.891 117.966 1.00 3.93  ? 362 GLU B OE2 1 
ATOM   6189 N N   . MET B 2 363 ? 138.313 111.836 122.669 1.00 2.52  ? 363 MET B N   1 
ATOM   6190 C CA  . MET B 2 363 ? 139.357 111.369 123.577 1.00 2.52  ? 363 MET B CA  1 
ATOM   6191 C C   . MET B 2 363 ? 138.782 111.024 124.943 1.00 2.52  ? 363 MET B C   1 
ATOM   6192 O O   . MET B 2 363 ? 139.155 110.010 125.544 1.00 2.52  ? 363 MET B O   1 
ATOM   6193 C CB  . MET B 2 363 ? 140.459 112.417 123.722 1.00 2.52  ? 363 MET B CB  1 
ATOM   6194 C CG  . MET B 2 363 ? 141.616 111.967 124.610 1.00 2.52  ? 363 MET B CG  1 
ATOM   6195 S SD  . MET B 2 363 ? 142.377 113.257 125.606 1.00 2.52  ? 363 MET B SD  1 
ATOM   6196 C CE  . MET B 2 363 ? 140.957 113.809 126.525 1.00 2.52  ? 363 MET B CE  1 
ATOM   6197 N N   . LEU B 2 364 ? 137.865 111.849 125.447 1.00 1.93  ? 364 LEU B N   1 
ATOM   6198 C CA  . LEU B 2 364 ? 137.350 111.607 126.789 1.00 1.93  ? 364 LEU B CA  1 
ATOM   6199 C C   . LEU B 2 364 ? 136.428 110.396 126.831 1.00 1.93  ? 364 LEU B C   1 
ATOM   6200 O O   . LEU B 2 364 ? 136.460 109.627 127.798 1.00 1.93  ? 364 LEU B O   1 
ATOM   6201 C CB  . LEU B 2 364 ? 136.652 112.851 127.318 1.00 1.93  ? 364 LEU B CB  1 
ATOM   6202 C CG  . LEU B 2 364 ? 137.705 113.639 128.084 1.00 1.93  ? 364 LEU B CG  1 
ATOM   6203 C CD1 . LEU B 2 364 ? 137.223 114.994 128.424 1.00 1.93  ? 364 LEU B CD1 1 
ATOM   6204 C CD2 . LEU B 2 364 ? 138.082 112.889 129.340 1.00 1.93  ? 364 LEU B CD2 1 
ATOM   6205 N N   . VAL B 2 365 ? 135.603 110.198 125.801 1.00 2.71  ? 365 VAL B N   1 
ATOM   6206 C CA  . VAL B 2 365 ? 134.791 108.987 125.749 1.00 2.71  ? 365 VAL B CA  1 
ATOM   6207 C C   . VAL B 2 365 ? 135.679 107.760 125.627 1.00 2.71  ? 365 VAL B C   1 
ATOM   6208 O O   . VAL B 2 365 ? 135.369 106.699 126.180 1.00 2.71  ? 365 VAL B O   1 
ATOM   6209 C CB  . VAL B 2 365 ? 133.775 109.074 124.596 1.00 2.71  ? 365 VAL B CB  1 
ATOM   6210 C CG1 . VAL B 2 365 ? 133.139 107.725 124.342 1.00 2.71  ? 365 VAL B CG1 1 
ATOM   6211 C CG2 . VAL B 2 365 ? 132.712 110.104 124.914 1.00 2.71  ? 365 VAL B CG2 1 
ATOM   6212 N N   . ASN B 2 366 ? 136.799 107.883 124.912 1.00 5.62  ? 366 ASN B N   1 
ATOM   6213 C CA  . ASN B 2 366 ? 137.735 106.772 124.803 1.00 5.62  ? 366 ASN B CA  1 
ATOM   6214 C C   . ASN B 2 366 ? 138.369 106.439 126.152 1.00 5.62  ? 366 ASN B C   1 
ATOM   6215 O O   . ASN B 2 366 ? 138.509 105.263 126.506 1.00 5.62  ? 366 ASN B O   1 
ATOM   6216 C CB  . ASN B 2 366 ? 138.801 107.119 123.767 1.00 5.62  ? 366 ASN B CB  1 
ATOM   6217 C CG  . ASN B 2 366 ? 139.695 105.955 123.429 1.00 5.62  ? 366 ASN B CG  1 
ATOM   6218 O OD1 . ASN B 2 366 ? 140.589 106.056 122.593 1.00 5.62  ? 366 ASN B OD1 1 
ATOM   6219 N ND2 . ASN B 2 366 ? 139.459 104.831 124.090 1.00 5.62  ? 366 ASN B ND2 1 
ATOM   6220 N N   . VAL B 2 367 ? 138.768 107.460 126.915 1.00 4.42  ? 367 VAL B N   1 
ATOM   6221 C CA  . VAL B 2 367 ? 139.427 107.221 128.201 1.00 4.42  ? 367 VAL B CA  1 
ATOM   6222 C C   . VAL B 2 367 ? 138.443 106.675 129.227 1.00 4.42  ? 367 VAL B C   1 
ATOM   6223 O O   . VAL B 2 367 ? 138.738 105.706 129.935 1.00 4.42  ? 367 VAL B O   1 
ATOM   6224 C CB  . VAL B 2 367 ? 140.107 108.503 128.713 1.00 4.42  ? 367 VAL B CB  1 
ATOM   6225 C CG1 . VAL B 2 367 ? 140.651 108.278 130.097 1.00 4.42  ? 367 VAL B CG1 1 
ATOM   6226 C CG2 . VAL B 2 367 ? 141.242 108.892 127.795 1.00 4.42  ? 367 VAL B CG2 1 
ATOM   6227 N N   . LEU B 2 368 ? 137.263 107.290 129.331 1.00 4.32  ? 368 LEU B N   1 
ATOM   6228 C CA  . LEU B 2 368 ? 136.328 106.918 130.389 1.00 4.32  ? 368 LEU B CA  1 
ATOM   6229 C C   . LEU B 2 368 ? 135.853 105.477 130.264 1.00 4.32  ? 368 LEU B C   1 
ATOM   6230 O O   . LEU B 2 368 ? 135.785 104.762 131.270 1.00 4.32  ? 368 LEU B O   1 
ATOM   6231 C CB  . LEU B 2 368 ? 135.131 107.862 130.389 1.00 4.32  ? 368 LEU B CB  1 
ATOM   6232 C CG  . LEU B 2 368 ? 135.172 108.983 131.420 1.00 4.32  ? 368 LEU B CG  1 
ATOM   6233 C CD1 . LEU B 2 368 ? 136.360 109.878 131.172 1.00 4.32  ? 368 LEU B CD1 1 
ATOM   6234 C CD2 . LEU B 2 368 ? 133.895 109.778 131.352 1.00 4.32  ? 368 LEU B CD2 1 
ATOM   6235 N N   . ASN B 2 369 ? 135.524 105.031 129.058 1.00 4.04  ? 369 ASN B N   1 
ATOM   6236 C CA  . ASN B 2 369 ? 135.004 103.682 128.869 1.00 4.04  ? 369 ASN B CA  1 
ATOM   6237 C C   . ASN B 2 369 ? 136.104 102.720 128.439 1.00 4.04  ? 369 ASN B C   1 
ATOM   6238 O O   . ASN B 2 369 ? 135.827 101.651 127.897 1.00 4.04  ? 369 ASN B O   1 
ATOM   6239 C CB  . ASN B 2 369 ? 133.876 103.686 127.839 1.00 4.04  ? 369 ASN B CB  1 
ATOM   6240 C CG  . ASN B 2 369 ? 132.534 104.030 128.448 1.00 4.04  ? 369 ASN B CG  1 
ATOM   6241 O OD1 . ASN B 2 369 ? 132.221 103.610 129.561 1.00 4.04  ? 369 ASN B OD1 1 
ATOM   6242 N ND2 . ASN B 2 369 ? 131.733 104.799 127.722 1.00 4.04  ? 369 ASN B ND2 1 
ATOM   6243 N N   . GLY C 3 2   ? 123.911 108.665 100.159 1.00 6.32  ? 1   GLY C N   1 
ATOM   6244 C CA  . GLY C 3 2   ? 124.523 107.960 99.048  1.00 6.32  ? 1   GLY C CA  1 
ATOM   6245 C C   . GLY C 3 2   ? 125.694 108.699 98.433  1.00 6.32  ? 1   GLY C C   1 
ATOM   6246 O O   . GLY C 3 2   ? 125.857 109.901 98.630  1.00 6.32  ? 1   GLY C O   1 
ATOM   6247 N N   . VAL C 3 3   ? 126.520 107.971 97.690  1.00 6.36  ? 2   VAL C N   1 
ATOM   6248 C CA  . VAL C 3 3   ? 127.645 108.543 96.965  1.00 6.36  ? 2   VAL C CA  1 
ATOM   6249 C C   . VAL C 3 3   ? 127.610 108.023 95.535  1.00 6.36  ? 2   VAL C C   1 
ATOM   6250 O O   . VAL C 3 3   ? 127.359 106.835 95.301  1.00 6.36  ? 2   VAL C O   1 
ATOM   6251 C CB  . VAL C 3 3   ? 128.993 108.213 97.643  1.00 6.36  ? 2   VAL C CB  1 
ATOM   6252 C CG1 . VAL C 3 3   ? 129.161 106.713 97.803  1.00 6.36  ? 2   VAL C CG1 1 
ATOM   6253 C CG2 . VAL C 3 3   ? 130.148 108.798 96.849  1.00 6.36  ? 2   VAL C CG2 1 
ATOM   6254 N N   . GLN C 3 4   ? 127.831 108.920 94.578  1.00 5.35  ? 3   GLN C N   1 
ATOM   6255 C CA  . GLN C 3 4   ? 127.851 108.578 93.164  1.00 5.35  ? 3   GLN C CA  1 
ATOM   6256 C C   . GLN C 3 4   ? 129.148 109.089 92.561  1.00 5.35  ? 3   GLN C C   1 
ATOM   6257 O O   . GLN C 3 4   ? 129.517 110.247 92.776  1.00 5.35  ? 3   GLN C O   1 
ATOM   6258 C CB  . GLN C 3 4   ? 126.648 109.184 92.436  1.00 5.35  ? 3   GLN C CB  1 
ATOM   6259 C CG  . GLN C 3 4   ? 125.350 109.078 93.216  1.00 5.35  ? 3   GLN C CG  1 
ATOM   6260 C CD  . GLN C 3 4   ? 124.233 109.901 92.611  1.00 5.35  ? 3   GLN C CD  1 
ATOM   6261 O OE1 . GLN C 3 4   ? 124.410 110.546 91.579  1.00 5.35  ? 3   GLN C OE1 1 
ATOM   6262 N NE2 . GLN C 3 4   ? 123.073 109.885 93.256  1.00 5.35  ? 3   GLN C NE2 1 
ATOM   6263 N N   . VAL C 3 5   ? 129.839 108.235 91.814  1.00 7.53  ? 4   VAL C N   1 
ATOM   6264 C CA  . VAL C 3 5   ? 131.092 108.598 91.161  1.00 7.53  ? 4   VAL C CA  1 
ATOM   6265 C C   . VAL C 3 5   ? 130.871 108.546 89.657  1.00 7.53  ? 4   VAL C C   1 
ATOM   6266 O O   . VAL C 3 5   ? 130.520 107.493 89.111  1.00 7.53  ? 4   VAL C O   1 
ATOM   6267 C CB  . VAL C 3 5   ? 132.245 107.676 91.577  1.00 7.53  ? 4   VAL C CB  1 
ATOM   6268 C CG1 . VAL C 3 5   ? 133.471 107.951 90.724  1.00 7.53  ? 4   VAL C CG1 1 
ATOM   6269 C CG2 . VAL C 3 5   ? 132.560 107.865 93.048  1.00 7.53  ? 4   VAL C CG2 1 
ATOM   6270 N N   . GLU C 3 6   ? 131.085 109.679 88.990  1.00 10.92 ? 5   GLU C N   1 
ATOM   6271 C CA  . GLU C 3 6   ? 130.866 109.814 87.551  1.00 10.92 ? 5   GLU C CA  1 
ATOM   6272 C C   . GLU C 3 6   ? 132.178 110.281 86.930  1.00 10.92 ? 5   GLU C C   1 
ATOM   6273 O O   . GLU C 3 6   ? 132.484 111.477 86.939  1.00 10.92 ? 5   GLU C O   1 
ATOM   6274 C CB  . GLU C 3 6   ? 129.732 110.791 87.264  1.00 10.92 ? 5   GLU C CB  1 
ATOM   6275 C CG  . GLU C 3 6   ? 128.410 110.394 87.890  1.00 10.92 ? 5   GLU C CG  1 
ATOM   6276 C CD  . GLU C 3 6   ? 127.333 111.432 87.674  1.00 10.92 ? 5   GLU C CD  1 
ATOM   6277 O OE1 . GLU C 3 6   ? 127.642 112.501 87.109  1.00 10.92 ? 5   GLU C OE1 1 
ATOM   6278 O OE2 . GLU C 3 6   ? 126.177 111.184 88.074  1.00 10.92 ? 5   GLU C OE2 1 
ATOM   6279 N N   . THR C 3 7   ? 132.947 109.341 86.388  1.00 14.90 ? 6   THR C N   1 
ATOM   6280 C CA  . THR C 3 7   ? 134.288 109.650 85.912  1.00 14.90 ? 6   THR C CA  1 
ATOM   6281 C C   . THR C 3 7   ? 134.243 110.560 84.691  1.00 14.90 ? 6   THR C C   1 
ATOM   6282 O O   . THR C 3 7   ? 133.495 110.310 83.741  1.00 14.90 ? 6   THR C O   1 
ATOM   6283 C CB  . THR C 3 7   ? 135.036 108.361 85.573  1.00 14.90 ? 6   THR C CB  1 
ATOM   6284 O OG1 . THR C 3 7   ? 135.159 107.556 86.753  1.00 14.90 ? 6   THR C OG1 1 
ATOM   6285 C CG2 . THR C 3 7   ? 136.423 108.672 85.027  1.00 14.90 ? 6   THR C CG2 1 
ATOM   6286 N N   . ILE C 3 8   ? 135.046 111.619 84.722  1.00 15.98 ? 7   ILE C N   1 
ATOM   6287 C CA  . ILE C 3 8   ? 135.298 112.449 83.549  1.00 15.98 ? 7   ILE C CA  1 
ATOM   6288 C C   . ILE C 3 8   ? 136.579 112.033 82.843  1.00 15.98 ? 7   ILE C C   1 
ATOM   6289 O O   . ILE C 3 8   ? 136.585 111.817 81.632  1.00 15.98 ? 7   ILE C O   1 
ATOM   6290 C CB  . ILE C 3 8   ? 135.332 113.949 83.927  1.00 15.98 ? 7   ILE C CB  1 
ATOM   6291 C CG1 . ILE C 3 8   ? 133.978 114.417 84.468  1.00 15.98 ? 7   ILE C CG1 1 
ATOM   6292 C CG2 . ILE C 3 8   ? 135.752 114.789 82.733  1.00 15.98 ? 7   ILE C CG2 1 
ATOM   6293 C CD1 . ILE C 3 8   ? 133.808 114.257 85.951  1.00 15.98 ? 7   ILE C CD1 1 
ATOM   6294 N N   . SER C 3 9   ? 137.677 111.910 83.582  1.00 18.18 ? 8   SER C N   1 
ATOM   6295 C CA  . SER C 3 9   ? 138.948 111.468 83.010  1.00 18.18 ? 8   SER C CA  1 
ATOM   6296 C C   . SER C 3 9   ? 139.465 110.275 83.800  1.00 18.18 ? 8   SER C C   1 
ATOM   6297 O O   . SER C 3 9   ? 139.795 110.425 84.995  1.00 18.18 ? 8   SER C O   1 
ATOM   6298 C CB  . SER C 3 9   ? 139.976 112.595 83.000  1.00 18.18 ? 8   SER C CB  1 
ATOM   6299 O OG  . SER C 3 9   ? 140.202 113.094 84.304  1.00 18.18 ? 8   SER C OG  1 
ATOM   6300 N N   . PRO C 3 10  ? 139.553 109.095 83.197  1.00 19.42 ? 9   PRO C N   1 
ATOM   6301 C CA  . PRO C 3 10  ? 140.071 107.927 83.912  1.00 19.42 ? 9   PRO C CA  1 
ATOM   6302 C C   . PRO C 3 10  ? 141.592 107.950 83.987  1.00 19.42 ? 9   PRO C C   1 
ATOM   6303 O O   . PRO C 3 10  ? 142.273 108.685 83.270  1.00 19.42 ? 9   PRO C O   1 
ATOM   6304 C CB  . PRO C 3 10  ? 139.576 106.752 83.065  1.00 19.42 ? 9   PRO C CB  1 
ATOM   6305 C CG  . PRO C 3 10  ? 139.497 107.308 81.682  1.00 19.42 ? 9   PRO C CG  1 
ATOM   6306 C CD  . PRO C 3 10  ? 139.172 108.777 81.810  1.00 19.42 ? 9   PRO C CD  1 
ATOM   6307 N N   . GLY C 3 11  ? 142.119 107.118 84.881  1.00 20.19 ? 10  GLY C N   1 
ATOM   6308 C CA  . GLY C 3 11  ? 143.553 106.997 85.044  1.00 20.19 ? 10  GLY C CA  1 
ATOM   6309 C C   . GLY C 3 11  ? 144.035 105.564 84.948  1.00 20.19 ? 10  GLY C C   1 
ATOM   6310 O O   . GLY C 3 11  ? 143.321 104.697 84.435  1.00 20.19 ? 10  GLY C O   1 
ATOM   6311 N N   . ASP C 3 12  ? 145.245 105.301 85.436  1.00 24.31 ? 11  ASP C N   1 
ATOM   6312 C CA  . ASP C 3 12  ? 145.793 103.952 85.409  1.00 24.31 ? 11  ASP C CA  1 
ATOM   6313 C C   . ASP C 3 12  ? 145.130 103.098 86.483  1.00 24.31 ? 11  ASP C C   1 
ATOM   6314 O O   . ASP C 3 12  ? 145.076 103.486 87.654  1.00 24.31 ? 11  ASP C O   1 
ATOM   6315 C CB  . ASP C 3 12  ? 147.308 103.984 85.612  1.00 24.31 ? 11  ASP C CB  1 
ATOM   6316 C CG  . ASP C 3 12  ? 147.729 104.910 86.736  1.00 24.31 ? 11  ASP C CG  1 
ATOM   6317 O OD1 . ASP C 3 12  ? 146.876 105.674 87.231  1.00 24.31 ? 11  ASP C OD1 1 
ATOM   6318 O OD2 . ASP C 3 12  ? 148.916 104.874 87.125  1.00 24.31 ? 11  ASP C OD2 1 
ATOM   6319 N N   . GLY C 3 13  ? 144.624 101.937 86.079  1.00 22.15 ? 12  GLY C N   1 
ATOM   6320 C CA  . GLY C 3 13  ? 143.957 101.016 86.973  1.00 22.15 ? 12  GLY C CA  1 
ATOM   6321 C C   . GLY C 3 13  ? 144.853 99.999  87.642  1.00 22.15 ? 12  GLY C C   1 
ATOM   6322 O O   . GLY C 3 13  ? 144.348 99.104  88.328  1.00 22.15 ? 12  GLY C O   1 
ATOM   6323 N N   . ARG C 3 14  ? 146.172 100.102 87.466  1.00 23.67 ? 13  ARG C N   1 
ATOM   6324 C CA  . ARG C 3 14  ? 147.082 99.146  88.085  1.00 23.67 ? 13  ARG C CA  1 
ATOM   6325 C C   . ARG C 3 14  ? 147.295 99.421  89.568  1.00 23.67 ? 13  ARG C C   1 
ATOM   6326 O O   . ARG C 3 14  ? 147.820 98.554  90.275  1.00 23.67 ? 13  ARG C O   1 
ATOM   6327 C CB  . ARG C 3 14  ? 148.428 99.154  87.358  1.00 23.67 ? 13  ARG C CB  1 
ATOM   6328 N N   . THR C 3 15  ? 146.904 100.597 90.052  1.00 24.40 ? 14  THR C N   1 
ATOM   6329 C CA  . THR C 3 15  ? 147.089 100.974 91.446  1.00 24.40 ? 14  THR C CA  1 
ATOM   6330 C C   . THR C 3 15  ? 145.779 101.511 92.004  1.00 24.40 ? 14  THR C C   1 
ATOM   6331 O O   . THR C 3 15  ? 145.069 102.263 91.328  1.00 24.40 ? 14  THR C O   1 
ATOM   6332 C CB  . THR C 3 15  ? 148.199 102.028 91.593  1.00 24.40 ? 14  THR C CB  1 
ATOM   6333 O OG1 . THR C 3 15  ? 149.426 101.508 91.068  1.00 24.40 ? 14  THR C OG1 1 
ATOM   6334 C CG2 . THR C 3 15  ? 148.404 102.396 93.055  1.00 24.40 ? 14  THR C CG2 1 
ATOM   6335 N N   . PHE C 3 16  ? 145.458 101.115 93.232  1.00 27.65 ? 15  PHE C N   1 
ATOM   6336 C CA  . PHE C 3 16  ? 144.277 101.591 93.932  1.00 27.65 ? 15  PHE C CA  1 
ATOM   6337 C C   . PHE C 3 16  ? 144.645 102.002 95.349  1.00 27.65 ? 15  PHE C C   1 
ATOM   6338 O O   . PHE C 3 16  ? 145.540 101.408 95.960  1.00 27.65 ? 15  PHE C O   1 
ATOM   6339 C CB  . PHE C 3 16  ? 143.186 100.511 93.978  1.00 27.65 ? 15  PHE C CB  1 
ATOM   6340 C CG  . PHE C 3 16  ? 142.384 100.403 92.713  1.00 27.65 ? 15  PHE C CG  1 
ATOM   6341 C CD1 . PHE C 3 16  ? 141.198 101.103 92.568  1.00 27.65 ? 15  PHE C CD1 1 
ATOM   6342 C CD2 . PHE C 3 16  ? 142.817 99.604  91.669  1.00 27.65 ? 15  PHE C CD2 1 
ATOM   6343 C CE1 . PHE C 3 16  ? 140.457 101.005 91.406  1.00 27.65 ? 15  PHE C CE1 1 
ATOM   6344 C CE2 . PHE C 3 16  ? 142.080 99.503  90.504  1.00 27.65 ? 15  PHE C CE2 1 
ATOM   6345 C CZ  . PHE C 3 16  ? 140.899 100.205 90.373  1.00 27.65 ? 15  PHE C CZ  1 
ATOM   6346 N N   . PRO C 3 17  ? 143.978 103.016 95.894  1.00 25.52 ? 16  PRO C N   1 
ATOM   6347 C CA  . PRO C 3 17  ? 144.263 103.423 97.274  1.00 25.52 ? 16  PRO C CA  1 
ATOM   6348 C C   . PRO C 3 17  ? 143.826 102.363 98.273  1.00 25.52 ? 16  PRO C C   1 
ATOM   6349 O O   . PRO C 3 17  ? 142.865 101.622 98.053  1.00 25.52 ? 16  PRO C O   1 
ATOM   6350 C CB  . PRO C 3 17  ? 143.455 104.714 97.444  1.00 25.52 ? 16  PRO C CB  1 
ATOM   6351 C CG  . PRO C 3 17  ? 142.400 104.659 96.399  1.00 25.52 ? 16  PRO C CG  1 
ATOM   6352 C CD  . PRO C 3 17  ? 142.938 103.847 95.262  1.00 25.52 ? 16  PRO C CD  1 
ATOM   6353 N N   . LYS C 3 18  ? 144.550 102.300 99.385  1.00 22.95 ? 17  LYS C N   1 
ATOM   6354 C CA  . LYS C 3 18  ? 144.271 101.366 100.466 1.00 22.95 ? 17  LYS C CA  1 
ATOM   6355 C C   . LYS C 3 18  ? 143.772 102.120 101.692 1.00 22.95 ? 17  LYS C C   1 
ATOM   6356 O O   . LYS C 3 18  ? 143.819 103.351 101.758 1.00 22.95 ? 17  LYS C O   1 
ATOM   6357 C CB  . LYS C 3 18  ? 145.519 100.546 100.814 1.00 22.95 ? 17  LYS C CB  1 
ATOM   6358 C CG  . LYS C 3 18  ? 146.067 99.719  99.662  1.00 22.95 ? 17  LYS C CG  1 
ATOM   6359 C CD  . LYS C 3 18  ? 144.988 98.855  99.032  1.00 22.95 ? 17  LYS C CD  1 
ATOM   6360 C CE  . LYS C 3 18  ? 145.574 97.912  97.993  1.00 22.95 ? 17  LYS C CE  1 
ATOM   6361 N NZ  . LYS C 3 18  ? 144.531 97.049  97.375  1.00 22.95 ? 17  LYS C NZ  1 
ATOM   6362 N N   . ARG C 3 19  ? 143.283 101.356 102.672 1.00 20.35 ? 18  ARG C N   1 
ATOM   6363 C CA  . ARG C 3 19  ? 142.789 101.966 103.903 1.00 20.35 ? 18  ARG C CA  1 
ATOM   6364 C C   . ARG C 3 19  ? 143.909 102.665 104.663 1.00 20.35 ? 18  ARG C C   1 
ATOM   6365 O O   . ARG C 3 19  ? 143.721 103.769 105.186 1.00 20.35 ? 18  ARG C O   1 
ATOM   6366 C CB  . ARG C 3 19  ? 142.119 100.913 104.784 1.00 20.35 ? 18  ARG C CB  1 
ATOM   6367 C CG  . ARG C 3 19  ? 141.546 101.471 106.077 1.00 20.35 ? 18  ARG C CG  1 
ATOM   6368 C CD  . ARG C 3 19  ? 140.811 100.405 106.871 1.00 20.35 ? 18  ARG C CD  1 
ATOM   6369 N NE  . ARG C 3 19  ? 139.561 100.009 106.229 1.00 20.35 ? 18  ARG C NE  1 
ATOM   6370 C CZ  . ARG C 3 19  ? 138.788 99.013  106.649 1.00 20.35 ? 18  ARG C CZ  1 
ATOM   6371 N NH1 . ARG C 3 19  ? 139.134 98.308  107.717 1.00 20.35 ? 18  ARG C NH1 1 
ATOM   6372 N NH2 . ARG C 3 19  ? 137.667 98.722  106.003 1.00 20.35 ? 18  ARG C NH2 1 
ATOM   6373 N N   . GLY C 3 20  ? 145.082 102.041 104.732 1.00 19.78 ? 19  GLY C N   1 
ATOM   6374 C CA  . GLY C 3 20  ? 146.213 102.627 105.418 1.00 19.78 ? 19  GLY C CA  1 
ATOM   6375 C C   . GLY C 3 20  ? 147.007 103.632 104.619 1.00 19.78 ? 19  GLY C C   1 
ATOM   6376 O O   . GLY C 3 20  ? 147.992 104.174 105.126 1.00 19.78 ? 19  GLY C O   1 
ATOM   6377 N N   . GLN C 3 21  ? 146.608 103.897 103.381 1.00 21.58 ? 20  GLN C N   1 
ATOM   6378 C CA  . GLN C 3 21  ? 147.294 104.839 102.511 1.00 21.58 ? 20  GLN C CA  1 
ATOM   6379 C C   . GLN C 3 21  ? 146.716 106.239 102.673 1.00 21.58 ? 20  GLN C C   1 
ATOM   6380 O O   . GLN C 3 21  ? 145.551 106.421 103.035 1.00 21.58 ? 20  GLN C O   1 
ATOM   6381 C CB  . GLN C 3 21  ? 147.191 104.396 101.048 1.00 21.58 ? 20  GLN C CB  1 
ATOM   6382 C CG  . GLN C 3 21  ? 148.011 103.163 100.710 1.00 21.58 ? 20  GLN C CG  1 
ATOM   6383 C CD  . GLN C 3 21  ? 148.263 103.020 99.222  1.00 21.58 ? 20  GLN C CD  1 
ATOM   6384 O OE1 . GLN C 3 21  ? 147.392 102.577 98.473  1.00 21.58 ? 20  GLN C OE1 1 
ATOM   6385 N NE2 . GLN C 3 21  ? 149.459 103.397 98.784  1.00 21.58 ? 20  GLN C NE2 1 
ATOM   6386 N N   . THR C 3 22  ? 147.554 107.234 102.397 1.00 21.15 ? 21  THR C N   1 
ATOM   6387 C CA  . THR C 3 22  ? 147.171 108.637 102.467 1.00 21.15 ? 21  THR C CA  1 
ATOM   6388 C C   . THR C 3 22  ? 147.112 109.208 101.057 1.00 21.15 ? 21  THR C C   1 
ATOM   6389 O O   . THR C 3 22  ? 148.095 109.138 100.312 1.00 21.15 ? 21  THR C O   1 
ATOM   6390 C CB  . THR C 3 22  ? 148.158 109.437 103.319 1.00 21.15 ? 21  THR C CB  1 
ATOM   6391 O OG1 . THR C 3 22  ? 148.291 108.819 104.605 1.00 21.15 ? 21  THR C OG1 1 
ATOM   6392 C CG2 . THR C 3 22  ? 147.667 110.863 103.500 1.00 21.15 ? 21  THR C CG2 1 
ATOM   6393 N N   . CYS C 3 23  ? 145.963 109.772 100.697 1.00 19.75 ? 22  CYS C N   1 
ATOM   6394 C CA  . CYS C 3 23  ? 145.740 110.317 99.368  1.00 19.75 ? 22  CYS C CA  1 
ATOM   6395 C C   . CYS C 3 23  ? 145.927 111.827 99.382  1.00 19.75 ? 22  CYS C C   1 
ATOM   6396 O O   . CYS C 3 23  ? 145.440 112.519 100.284 1.00 19.75 ? 22  CYS C O   1 
ATOM   6397 C CB  . CYS C 3 23  ? 144.337 109.971 98.867  1.00 19.75 ? 22  CYS C CB  1 
ATOM   6398 S SG  . CYS C 3 23  ? 143.865 108.245 99.111  1.00 19.75 ? 22  CYS C SG  1 
ATOM   6399 N N   . VAL C 3 24  ? 146.641 112.327 98.376  1.00 18.04 ? 23  VAL C N   1 
ATOM   6400 C CA  . VAL C 3 24  ? 146.885 113.749 98.176  1.00 18.04 ? 23  VAL C CA  1 
ATOM   6401 C C   . VAL C 3 24  ? 146.157 114.144 96.899  1.00 18.04 ? 23  VAL C C   1 
ATOM   6402 O O   . VAL C 3 24  ? 146.508 113.680 95.806  1.00 18.04 ? 23  VAL C O   1 
ATOM   6403 C CB  . VAL C 3 24  ? 148.384 114.058 98.080  1.00 18.04 ? 23  VAL C CB  1 
ATOM   6404 C CG1 . VAL C 3 24  ? 148.627 115.548 98.183  1.00 18.04 ? 23  VAL C CG1 1 
ATOM   6405 C CG2 . VAL C 3 24  ? 149.152 113.309 99.159  1.00 18.04 ? 23  VAL C CG2 1 
ATOM   6406 N N   . VAL C 3 25  ? 145.145 115.005 97.034  1.00 13.37 ? 24  VAL C N   1 
ATOM   6407 C CA  . VAL C 3 25  ? 144.241 115.351 95.947  1.00 13.37 ? 24  VAL C CA  1 
ATOM   6408 C C   . VAL C 3 25  ? 144.100 116.866 95.865  1.00 13.37 ? 24  VAL C C   1 
ATOM   6409 O O   . VAL C 3 25  ? 144.409 117.597 96.808  1.00 13.37 ? 24  VAL C O   1 
ATOM   6410 C CB  . VAL C 3 25  ? 142.849 114.699 96.122  1.00 13.37 ? 24  VAL C CB  1 
ATOM   6411 C CG1 . VAL C 3 25  ? 142.980 113.215 96.409  1.00 13.37 ? 24  VAL C CG1 1 
ATOM   6412 C CG2 . VAL C 3 25  ? 142.080 115.383 97.241  1.00 13.37 ? 24  VAL C CG2 1 
ATOM   6413 N N   . HIS C 3 26  ? 143.635 117.332 94.708  1.00 9.36  ? 25  HIS C N   1 
ATOM   6414 C CA  . HIS C 3 26  ? 143.224 118.717 94.506  1.00 9.36  ? 25  HIS C CA  1 
ATOM   6415 C C   . HIS C 3 26  ? 141.731 118.723 94.211  1.00 9.36  ? 25  HIS C C   1 
ATOM   6416 O O   . HIS C 3 26  ? 141.296 118.148 93.209  1.00 9.36  ? 25  HIS C O   1 
ATOM   6417 C CB  . HIS C 3 26  ? 143.999 119.366 93.358  1.00 9.36  ? 25  HIS C CB  1 
ATOM   6418 C CG  . HIS C 3 26  ? 145.156 120.206 93.802  1.00 9.36  ? 25  HIS C CG  1 
ATOM   6419 N ND1 . HIS C 3 26  ? 145.015 121.280 94.654  1.00 9.36  ? 25  HIS C ND1 1 
ATOM   6420 C CD2 . HIS C 3 26  ? 146.473 120.141 93.495  1.00 9.36  ? 25  HIS C CD2 1 
ATOM   6421 C CE1 . HIS C 3 26  ? 146.197 121.833 94.863  1.00 9.36  ? 25  HIS C CE1 1 
ATOM   6422 N NE2 . HIS C 3 26  ? 147.099 121.161 94.171  1.00 9.36  ? 25  HIS C NE2 1 
ATOM   6423 N N   . TYR C 3 27  ? 140.951 119.374 95.069  1.00 4.91  ? 26  TYR C N   1 
ATOM   6424 C CA  . TYR C 3 27  ? 139.500 119.303 94.988  1.00 4.91  ? 26  TYR C CA  1 
ATOM   6425 C C   . TYR C 3 27  ? 138.896 120.695 94.906  1.00 4.91  ? 26  TYR C C   1 
ATOM   6426 O O   . TYR C 3 27  ? 139.449 121.662 95.432  1.00 4.91  ? 26  TYR C O   1 
ATOM   6427 C CB  . TYR C 3 27  ? 138.911 118.565 96.189  1.00 4.91  ? 26  TYR C CB  1 
ATOM   6428 C CG  . TYR C 3 27  ? 138.752 119.420 97.422  1.00 4.91  ? 26  TYR C CG  1 
ATOM   6429 C CD1 . TYR C 3 27  ? 139.858 119.850 98.139  1.00 4.91  ? 26  TYR C CD1 1 
ATOM   6430 C CD2 . TYR C 3 27  ? 137.495 119.787 97.875  1.00 4.91  ? 26  TYR C CD2 1 
ATOM   6431 C CE1 . TYR C 3 27  ? 139.717 120.625 99.271  1.00 4.91  ? 26  TYR C CE1 1 
ATOM   6432 C CE2 . TYR C 3 27  ? 137.345 120.561 99.005  1.00 4.91  ? 26  TYR C CE2 1 
ATOM   6433 C CZ  . TYR C 3 27  ? 138.459 120.976 99.699  1.00 4.91  ? 26  TYR C CZ  1 
ATOM   6434 O OH  . TYR C 3 27  ? 138.313 121.749 100.826 1.00 4.91  ? 26  TYR C OH  1 
ATOM   6435 N N   . THR C 3 28  ? 137.749 120.783 94.230  1.00 3.19  ? 27  THR C N   1 
ATOM   6436 C CA  . THR C 3 28  ? 137.001 122.031 94.069  1.00 3.19  ? 27  THR C CA  1 
ATOM   6437 C C   . THR C 3 28  ? 135.538 121.749 94.402  1.00 3.19  ? 27  THR C C   1 
ATOM   6438 O O   . THR C 3 28  ? 134.738 121.466 93.508  1.00 3.19  ? 27  THR C O   1 
ATOM   6439 C CB  . THR C 3 28  ? 137.152 122.585 92.656  1.00 3.19  ? 27  THR C CB  1 
ATOM   6440 O OG1 . THR C 3 28  ? 136.650 121.630 91.715  1.00 3.19  ? 27  THR C OG1 1 
ATOM   6441 C CG2 . THR C 3 28  ? 138.612 122.871 92.342  1.00 3.19  ? 27  THR C CG2 1 
ATOM   6442 N N   . GLY C 3 29  ? 135.185 121.847 95.680  1.00 3.48  ? 28  GLY C N   1 
ATOM   6443 C CA  . GLY C 3 29  ? 133.831 121.547 96.093  1.00 3.48  ? 28  GLY C CA  1 
ATOM   6444 C C   . GLY C 3 29  ? 132.824 122.549 95.566  1.00 3.48  ? 28  GLY C C   1 
ATOM   6445 O O   . GLY C 3 29  ? 133.156 123.665 95.176  1.00 3.48  ? 28  GLY C O   1 
ATOM   6446 N N   . MET C 3 30  ? 131.562 122.125 95.536  1.00 3.14  ? 29  MET C N   1 
ATOM   6447 C CA  . MET C 3 30  ? 130.456 122.955 95.069  1.00 3.14  ? 29  MET C CA  1 
ATOM   6448 C C   . MET C 3 30  ? 129.234 122.641 95.924  1.00 3.14  ? 29  MET C C   1 
ATOM   6449 O O   . MET C 3 30  ? 129.335 122.020 96.983  1.00 3.14  ? 29  MET C O   1 
ATOM   6450 C CB  . MET C 3 30  ? 130.160 122.721 93.580  1.00 3.14  ? 29  MET C CB  1 
ATOM   6451 C CG  . MET C 3 30  ? 131.375 122.545 92.684  1.00 3.14  ? 29  MET C CG  1 
ATOM   6452 S SD  . MET C 3 30  ? 130.965 122.629 90.932  1.00 3.14  ? 29  MET C SD  1 
ATOM   6453 C CE  . MET C 3 30  ? 132.602 122.644 90.204  1.00 3.14  ? 29  MET C CE  1 
ATOM   6454 N N   . LEU C 3 31  ? 128.065 123.080 95.462  1.00 5.67  ? 30  LEU C N   1 
ATOM   6455 C CA  . LEU C 3 31  ? 126.797 122.670 96.057  1.00 5.67  ? 30  LEU C CA  1 
ATOM   6456 C C   . LEU C 3 31  ? 125.844 122.147 94.992  1.00 5.67  ? 30  LEU C C   1 
ATOM   6457 O O   . LEU C 3 31  ? 126.244 121.918 93.847  1.00 5.67  ? 30  LEU C O   1 
ATOM   6458 C CB  . LEU C 3 31  ? 126.140 123.816 96.826  1.00 5.67  ? 30  LEU C CB  1 
ATOM   6459 C CG  . LEU C 3 31  ? 126.467 123.962 98.312  1.00 5.67  ? 30  LEU C CG  1 
ATOM   6460 C CD1 . LEU C 3 31  ? 127.861 124.491 98.533  1.00 5.67  ? 30  LEU C CD1 1 
ATOM   6461 C CD2 . LEU C 3 31  ? 125.444 124.865 98.974  1.00 5.67  ? 30  LEU C CD2 1 
ATOM   6462 N N   . GLU C 3 32  ? 124.580 121.945 95.369  1.00 8.61  ? 31  GLU C N   1 
ATOM   6463 C CA  . GLU C 3 32  ? 123.604 121.383 94.442  1.00 8.61  ? 31  GLU C CA  1 
ATOM   6464 C C   . GLU C 3 32  ? 123.314 122.322 93.276  1.00 8.61  ? 31  GLU C C   1 
ATOM   6465 O O   . GLU C 3 32  ? 123.034 121.856 92.166  1.00 8.61  ? 31  GLU C O   1 
ATOM   6466 C CB  . GLU C 3 32  ? 122.315 121.041 95.191  1.00 8.61  ? 31  GLU C CB  1 
ATOM   6467 C CG  . GLU C 3 32  ? 121.579 122.244 95.769  1.00 8.61  ? 31  GLU C CG  1 
ATOM   6468 C CD  . GLU C 3 32  ? 122.093 122.654 97.140  1.00 8.61  ? 31  GLU C CD  1 
ATOM   6469 O OE1 . GLU C 3 32  ? 123.284 122.418 97.431  1.00 8.61  ? 31  GLU C OE1 1 
ATOM   6470 O OE2 . GLU C 3 32  ? 121.303 123.214 97.928  1.00 8.61  ? 31  GLU C OE2 1 
ATOM   6471 N N   . ASP C 3 33  ? 123.375 123.634 93.498  1.00 7.22  ? 32  ASP C N   1 
ATOM   6472 C CA  . ASP C 3 33  ? 123.085 124.613 92.461  1.00 7.22  ? 32  ASP C CA  1 
ATOM   6473 C C   . ASP C 3 33  ? 124.342 125.206 91.838  1.00 7.22  ? 32  ASP C C   1 
ATOM   6474 O O   . ASP C 3 33  ? 124.254 126.210 91.126  1.00 7.22  ? 32  ASP C O   1 
ATOM   6475 C CB  . ASP C 3 33  ? 122.193 125.727 93.018  1.00 7.22  ? 32  ASP C CB  1 
ATOM   6476 C CG  . ASP C 3 33  ? 122.798 126.420 94.223  1.00 7.22  ? 32  ASP C CG  1 
ATOM   6477 O OD1 . ASP C 3 33  ? 123.950 126.105 94.586  1.00 7.22  ? 32  ASP C OD1 1 
ATOM   6478 O OD2 . ASP C 3 33  ? 122.116 127.282 94.814  1.00 7.22  ? 32  ASP C OD2 1 
ATOM   6479 N N   . GLY C 3 34  ? 125.507 124.615 92.091  1.00 6.69  ? 33  GLY C N   1 
ATOM   6480 C CA  . GLY C 3 34  ? 126.743 125.074 91.496  1.00 6.69  ? 33  GLY C CA  1 
ATOM   6481 C C   . GLY C 3 34  ? 127.432 126.211 92.217  1.00 6.69  ? 33  GLY C C   1 
ATOM   6482 O O   . GLY C 3 34  ? 128.459 126.697 91.726  1.00 6.69  ? 33  GLY C O   1 
ATOM   6483 N N   . LYS C 3 35  ? 126.912 126.652 93.359  1.00 6.82  ? 34  LYS C N   1 
ATOM   6484 C CA  . LYS C 3 35  ? 127.518 127.745 94.116  1.00 6.82  ? 34  LYS C CA  1 
ATOM   6485 C C   . LYS C 3 35  ? 128.778 127.231 94.799  1.00 6.82  ? 34  LYS C C   1 
ATOM   6486 O O   . LYS C 3 35  ? 128.711 126.601 95.855  1.00 6.82  ? 34  LYS C O   1 
ATOM   6487 C CB  . LYS C 3 35  ? 126.526 128.296 95.134  1.00 6.82  ? 34  LYS C CB  1 
ATOM   6488 C CG  . LYS C 3 35  ? 127.098 129.364 96.046  1.00 6.82  ? 34  LYS C CG  1 
ATOM   6489 C CD  . LYS C 3 35  ? 126.179 129.631 97.223  1.00 6.82  ? 34  LYS C CD  1 
ATOM   6490 C CE  . LYS C 3 35  ? 126.477 130.978 97.854  1.00 6.82  ? 34  LYS C CE  1 
ATOM   6491 N NZ  . LYS C 3 35  ? 127.884 131.070 98.329  1.00 6.82  ? 34  LYS C NZ  1 
ATOM   6492 N N   . LYS C 3 36  ? 129.935 127.495 94.195  1.00 3.70  ? 35  LYS C N   1 
ATOM   6493 C CA  . LYS C 3 36  ? 131.192 126.989 94.731  1.00 3.70  ? 35  LYS C CA  1 
ATOM   6494 C C   . LYS C 3 36  ? 131.435 127.544 96.127  1.00 3.70  ? 35  LYS C C   1 
ATOM   6495 O O   . LYS C 3 36  ? 131.258 128.740 96.371  1.00 3.70  ? 35  LYS C O   1 
ATOM   6496 C CB  . LYS C 3 36  ? 132.346 127.356 93.800  1.00 3.70  ? 35  LYS C CB  1 
ATOM   6497 C CG  . LYS C 3 36  ? 133.699 126.855 94.263  1.00 3.70  ? 35  LYS C CG  1 
ATOM   6498 C CD  . LYS C 3 36  ? 134.635 126.647 93.085  1.00 3.70  ? 35  LYS C CD  1 
ATOM   6499 C CE  . LYS C 3 36  ? 135.482 127.876 92.816  1.00 3.70  ? 35  LYS C CE  1 
ATOM   6500 N NZ  . LYS C 3 36  ? 136.600 128.013 93.786  1.00 3.70  ? 35  LYS C NZ  1 
ATOM   6501 N N   . PHE C 3 37  ? 131.833 126.666 97.052  1.00 4.01  ? 36  PHE C N   1 
ATOM   6502 C CA  . PHE C 3 37  ? 131.997 127.046 98.446  1.00 4.01  ? 36  PHE C CA  1 
ATOM   6503 C C   . PHE C 3 37  ? 133.435 126.979 98.930  1.00 4.01  ? 36  PHE C C   1 
ATOM   6504 O O   . PHE C 3 37  ? 133.779 127.687 99.879  1.00 4.01  ? 36  PHE C O   1 
ATOM   6505 C CB  . PHE C 3 37  ? 131.131 126.154 99.348  1.00 4.01  ? 36  PHE C CB  1 
ATOM   6506 C CG  . PHE C 3 37  ? 131.638 124.742 99.488  1.00 4.01  ? 36  PHE C CG  1 
ATOM   6507 C CD1 . PHE C 3 37  ? 131.202 123.740 98.642  1.00 4.01  ? 36  PHE C CD1 1 
ATOM   6508 C CD2 . PHE C 3 37  ? 132.505 124.404 100.515 1.00 4.01  ? 36  PHE C CD2 1 
ATOM   6509 C CE1 . PHE C 3 37  ? 131.659 122.445 98.784  1.00 4.01  ? 36  PHE C CE1 1 
ATOM   6510 C CE2 . PHE C 3 37  ? 132.961 123.109 100.663 1.00 4.01  ? 36  PHE C CE2 1 
ATOM   6511 C CZ  . PHE C 3 37  ? 132.536 122.129 99.796  1.00 4.01  ? 36  PHE C CZ  1 
ATOM   6512 N N   . ASP C 3 38  ? 134.271 126.146 98.318  1.00 2.39  ? 37  ASP C N   1 
ATOM   6513 C CA  . ASP C 3 38  ? 135.669 126.025 98.702  1.00 2.39  ? 37  ASP C CA  1 
ATOM   6514 C C   . ASP C 3 38  ? 136.420 125.368 97.557  1.00 2.39  ? 37  ASP C C   1 
ATOM   6515 O O   . ASP C 3 38  ? 135.821 124.819 96.631  1.00 2.39  ? 37  ASP C O   1 
ATOM   6516 C CB  . ASP C 3 38  ? 135.833 125.222 99.994  1.00 2.39  ? 37  ASP C CB  1 
ATOM   6517 C CG  . ASP C 3 38  ? 137.145 125.504 100.692 1.00 2.39  ? 37  ASP C CG  1 
ATOM   6518 O OD1 . ASP C 3 38  ? 138.200 125.391 100.034 1.00 2.39  ? 37  ASP C OD1 1 
ATOM   6519 O OD2 . ASP C 3 38  ? 137.124 125.831 101.898 1.00 2.39  ? 37  ASP C OD2 1 
ATOM   6520 N N   . SER C 3 39  ? 137.745 125.433 97.629  1.00 3.55  ? 38  SER C N   1 
ATOM   6521 C CA  . SER C 3 39  ? 138.575 124.820 96.605  1.00 3.55  ? 38  SER C CA  1 
ATOM   6522 C C   . SER C 3 39  ? 139.967 124.593 97.165  1.00 3.55  ? 38  SER C C   1 
ATOM   6523 O O   . SER C 3 39  ? 140.335 125.142 98.204  1.00 3.55  ? 38  SER C O   1 
ATOM   6524 C CB  . SER C 3 39  ? 138.646 125.682 95.343  1.00 3.55  ? 38  SER C CB  1 
ATOM   6525 O OG  . SER C 3 39  ? 139.642 125.195 94.463  1.00 3.55  ? 38  SER C OG  1 
ATOM   6526 N N   . SER C 3 40  ? 140.733 123.765 96.460  1.00 5.39  ? 39  SER C N   1 
ATOM   6527 C CA  . SER C 3 40  ? 142.130 123.525 96.787  1.00 5.39  ? 39  SER C CA  1 
ATOM   6528 C C   . SER C 3 40  ? 143.071 124.173 95.786  1.00 5.39  ? 39  SER C C   1 
ATOM   6529 O O   . SER C 3 40  ? 144.278 123.922 95.833  1.00 5.39  ? 39  SER C O   1 
ATOM   6530 C CB  . SER C 3 40  ? 142.416 122.027 96.870  1.00 5.39  ? 39  SER C CB  1 
ATOM   6531 O OG  . SER C 3 40  ? 143.804 121.797 97.032  1.00 5.39  ? 39  SER C OG  1 
ATOM   6532 N N   . ARG C 3 41  ? 142.545 124.981 94.870  1.00 8.45  ? 40  ARG C N   1 
ATOM   6533 C CA  . ARG C 3 41  ? 143.370 125.765 93.965  1.00 8.45  ? 40  ARG C CA  1 
ATOM   6534 C C   . ARG C 3 41  ? 143.351 127.252 94.291  1.00 8.45  ? 40  ARG C C   1 
ATOM   6535 O O   . ARG C 3 41  ? 144.148 128.004 93.720  1.00 8.45  ? 40  ARG C O   1 
ATOM   6536 C CB  . ARG C 3 41  ? 142.927 125.542 92.516  1.00 8.45  ? 40  ARG C CB  1 
ATOM   6537 C CG  . ARG C 3 41  ? 143.291 124.167 91.981  1.00 8.45  ? 40  ARG C CG  1 
ATOM   6538 C CD  . ARG C 3 41  ? 142.787 123.961 90.565  1.00 8.45  ? 40  ARG C CD  1 
ATOM   6539 N NE  . ARG C 3 41  ? 143.191 122.663 90.032  1.00 8.45  ? 40  ARG C NE  1 
ATOM   6540 C CZ  . ARG C 3 41  ? 142.487 121.546 90.178  1.00 8.45  ? 40  ARG C CZ  1 
ATOM   6541 N NH1 . ARG C 3 41  ? 141.340 121.566 90.842  1.00 8.45  ? 40  ARG C NH1 1 
ATOM   6542 N NH2 . ARG C 3 41  ? 142.929 120.408 89.661  1.00 8.45  ? 40  ARG C NH2 1 
ATOM   6543 N N   . ASP C 3 42  ? 142.460 127.694 95.184  1.00 8.50  ? 41  ASP C N   1 
ATOM   6544 C CA  . ASP C 3 42  ? 142.580 129.038 95.736  1.00 8.50  ? 41  ASP C CA  1 
ATOM   6545 C C   . ASP C 3 42  ? 143.901 129.192 96.473  1.00 8.50  ? 41  ASP C C   1 
ATOM   6546 O O   . ASP C 3 42  ? 144.590 130.208 96.330  1.00 8.50  ? 41  ASP C O   1 
ATOM   6547 C CB  . ASP C 3 42  ? 141.407 129.337 96.670  1.00 8.50  ? 41  ASP C CB  1 
ATOM   6548 C CG  . ASP C 3 42  ? 140.065 129.259 95.968  1.00 8.50  ? 41  ASP C CG  1 
ATOM   6549 O OD1 . ASP C 3 42  ? 140.046 129.092 94.731  1.00 8.50  ? 41  ASP C OD1 1 
ATOM   6550 O OD2 . ASP C 3 42  ? 139.027 129.372 96.654  1.00 8.50  ? 41  ASP C OD2 1 
ATOM   6551 N N   . ARG C 3 43  ? 144.267 128.192 97.265  1.00 8.21  ? 42  ARG C N   1 
ATOM   6552 C CA  . ARG C 3 43  ? 145.611 128.075 97.804  1.00 8.21  ? 42  ARG C CA  1 
ATOM   6553 C C   . ARG C 3 43  ? 146.420 127.128 96.930  1.00 8.21  ? 42  ARG C C   1 
ATOM   6554 O O   . ARG C 3 43  ? 145.879 126.178 96.360  1.00 8.21  ? 42  ARG C O   1 
ATOM   6555 C CB  . ARG C 3 43  ? 145.573 127.567 99.246  1.00 8.21  ? 42  ARG C CB  1 
ATOM   6556 C CG  . ARG C 3 43  ? 144.966 126.185 99.392  1.00 8.21  ? 42  ARG C CG  1 
ATOM   6557 C CD  . ARG C 3 43  ? 144.884 125.763 100.844 1.00 8.21  ? 42  ARG C CD  1 
ATOM   6558 N NE  . ARG C 3 43  ? 144.304 124.434 100.994 1.00 8.21  ? 42  ARG C NE  1 
ATOM   6559 C CZ  . ARG C 3 43  ? 143.004 124.205 101.140 1.00 8.21  ? 42  ARG C CZ  1 
ATOM   6560 N NH1 . ARG C 3 43  ? 142.150 125.219 101.162 1.00 8.21  ? 42  ARG C NH1 1 
ATOM   6561 N NH2 . ARG C 3 43  ? 142.556 122.965 101.268 1.00 8.21  ? 42  ARG C NH2 1 
ATOM   6562 N N   . ASN C 3 44  ? 147.714 127.400 96.810  1.00 12.64 ? 43  ASN C N   1 
ATOM   6563 C CA  . ASN C 3 44  ? 148.585 126.558 95.993  1.00 12.64 ? 43  ASN C CA  1 
ATOM   6564 C C   . ASN C 3 44  ? 149.160 125.408 96.815  1.00 12.64 ? 43  ASN C C   1 
ATOM   6565 O O   . ASN C 3 44  ? 150.371 125.279 96.987  1.00 12.64 ? 43  ASN C O   1 
ATOM   6566 C CB  . ASN C 3 44  ? 149.692 127.403 95.373  1.00 12.64 ? 43  ASN C CB  1 
ATOM   6567 C CG  . ASN C 3 44  ? 150.510 126.639 94.344  1.00 12.64 ? 43  ASN C CG  1 
ATOM   6568 O OD1 . ASN C 3 44  ? 150.276 125.456 94.098  1.00 12.64 ? 43  ASN C OD1 1 
ATOM   6569 N ND2 . ASN C 3 44  ? 151.480 127.317 93.741  1.00 12.64 ? 43  ASN C ND2 1 
ATOM   6570 N N   . LYS C 3 45  ? 148.278 124.558 97.339  1.00 12.39 ? 44  LYS C N   1 
ATOM   6571 C CA  . LYS C 3 45  ? 148.715 123.420 98.135  1.00 12.39 ? 44  LYS C CA  1 
ATOM   6572 C C   . LYS C 3 45  ? 147.686 122.296 98.085  1.00 12.39 ? 44  LYS C C   1 
ATOM   6573 O O   . LYS C 3 45  ? 146.496 122.528 98.334  1.00 12.39 ? 44  LYS C O   1 
ATOM   6574 C CB  . LYS C 3 45  ? 148.973 123.845 99.580  1.00 12.39 ? 44  LYS C CB  1 
ATOM   6575 C CG  . LYS C 3 45  ? 150.022 123.005 100.272 1.00 12.39 ? 44  LYS C CG  1 
ATOM   6576 C CD  . LYS C 3 45  ? 150.791 123.814 101.294 1.00 12.39 ? 44  LYS C CD  1 
ATOM   6577 C CE  . LYS C 3 45  ? 152.026 123.062 101.752 1.00 12.39 ? 44  LYS C CE  1 
ATOM   6578 N NZ  . LYS C 3 45  ? 152.995 122.856 100.640 1.00 12.39 ? 44  LYS C NZ  1 
ATOM   6579 N N   . PRO C 3 46  ? 148.103 121.075 97.768  1.00 13.52 ? 45  PRO C N   1 
ATOM   6580 C CA  . PRO C 3 46  ? 147.156 119.957 97.721  1.00 13.52 ? 45  PRO C CA  1 
ATOM   6581 C C   . PRO C 3 46  ? 146.690 119.555 99.112  1.00 13.52 ? 45  PRO C C   1 
ATOM   6582 O O   . PRO C 3 46  ? 147.322 119.854 100.126 1.00 13.52 ? 45  PRO C O   1 
ATOM   6583 C CB  . PRO C 3 46  ? 147.961 118.831 97.059  1.00 13.52 ? 45  PRO C CB  1 
ATOM   6584 C CG  . PRO C 3 46  ? 149.178 119.494 96.473  1.00 13.52 ? 45  PRO C CG  1 
ATOM   6585 C CD  . PRO C 3 46  ? 149.452 120.673 97.341  1.00 13.52 ? 45  PRO C CD  1 
ATOM   6586 N N   . PHE C 3 47  ? 145.560 118.854 99.141  1.00 11.50 ? 46  PHE C N   1 
ATOM   6587 C CA  . PHE C 3 47  ? 144.922 118.423 100.378 1.00 11.50 ? 46  PHE C CA  1 
ATOM   6588 C C   . PHE C 3 47  ? 145.168 116.935 100.590 1.00 11.50 ? 46  PHE C C   1 
ATOM   6589 O O   . PHE C 3 47  ? 144.927 116.127 99.689  1.00 11.50 ? 46  PHE C O   1 
ATOM   6590 C CB  . PHE C 3 47  ? 143.422 118.715 100.334 1.00 11.50 ? 46  PHE C CB  1 
ATOM   6591 C CG  . PHE C 3 47  ? 142.657 118.163 101.501 1.00 11.50 ? 46  PHE C CG  1 
ATOM   6592 C CD1 . PHE C 3 47  ? 142.865 118.651 102.777 1.00 11.50 ? 46  PHE C CD1 1 
ATOM   6593 C CD2 . PHE C 3 47  ? 141.718 117.167 101.319 1.00 11.50 ? 46  PHE C CD2 1 
ATOM   6594 C CE1 . PHE C 3 47  ? 142.157 118.150 103.849 1.00 11.50 ? 46  PHE C CE1 1 
ATOM   6595 C CE2 . PHE C 3 47  ? 141.009 116.663 102.388 1.00 11.50 ? 46  PHE C CE2 1 
ATOM   6596 C CZ  . PHE C 3 47  ? 141.228 117.156 103.654 1.00 11.50 ? 46  PHE C CZ  1 
ATOM   6597 N N   . LYS C 3 48  ? 145.643 116.578 101.781 1.00 13.11 ? 47  LYS C N   1 
ATOM   6598 C CA  . LYS C 3 48  ? 146.004 115.207 102.112 1.00 13.11 ? 47  LYS C CA  1 
ATOM   6599 C C   . LYS C 3 48  ? 145.055 114.652 103.165 1.00 13.11 ? 47  LYS C C   1 
ATOM   6600 O O   . LYS C 3 48  ? 144.703 115.349 104.121 1.00 13.11 ? 47  LYS C O   1 
ATOM   6601 C CB  . LYS C 3 48  ? 147.439 115.129 102.637 1.00 13.11 ? 47  LYS C CB  1 
ATOM   6602 C CG  . LYS C 3 48  ? 148.467 115.840 101.782 1.00 13.11 ? 47  LYS C CG  1 
ATOM   6603 C CD  . LYS C 3 48  ? 149.866 115.640 102.342 1.00 13.11 ? 47  LYS C CD  1 
ATOM   6604 C CE  . LYS C 3 48  ? 150.016 116.327 103.692 1.00 13.11 ? 47  LYS C CE  1 
ATOM   6605 N NZ  . LYS C 3 48  ? 151.390 116.192 104.249 1.00 13.11 ? 47  LYS C NZ  1 
ATOM   6606 N N   . PHE C 3 49  ? 144.647 113.397 102.990 1.00 15.88 ? 48  PHE C N   1 
ATOM   6607 C CA  . PHE C 3 49  ? 143.845 112.744 104.018 1.00 15.88 ? 48  PHE C CA  1 
ATOM   6608 C C   . PHE C 3 49  ? 144.056 111.240 103.935 1.00 15.88 ? 48  PHE C C   1 
ATOM   6609 O O   . PHE C 3 49  ? 144.308 110.695 102.859 1.00 15.88 ? 48  PHE C O   1 
ATOM   6610 C CB  . PHE C 3 49  ? 142.354 113.087 103.886 1.00 15.88 ? 48  PHE C CB  1 
ATOM   6611 C CG  . PHE C 3 49  ? 141.660 112.376 102.761 1.00 15.88 ? 48  PHE C CG  1 
ATOM   6612 C CD1 . PHE C 3 49  ? 141.740 112.853 101.467 1.00 15.88 ? 48  PHE C CD1 1 
ATOM   6613 C CD2 . PHE C 3 49  ? 140.900 111.249 103.006 1.00 15.88 ? 48  PHE C CD2 1 
ATOM   6614 C CE1 . PHE C 3 49  ? 141.097 112.202 100.435 1.00 15.88 ? 48  PHE C CE1 1 
ATOM   6615 C CE2 . PHE C 3 49  ? 140.253 110.596 101.978 1.00 15.88 ? 48  PHE C CE2 1 
ATOM   6616 C CZ  . PHE C 3 49  ? 140.351 111.074 100.692 1.00 15.88 ? 48  PHE C CZ  1 
ATOM   6617 N N   . MET C 3 50  ? 143.941 110.578 105.082 1.00 17.20 ? 49  MET C N   1 
ATOM   6618 C CA  . MET C 3 50  ? 144.127 109.138 105.185 1.00 17.20 ? 49  MET C CA  1 
ATOM   6619 C C   . MET C 3 50  ? 142.796 108.463 105.485 1.00 17.20 ? 49  MET C C   1 
ATOM   6620 O O   . MET C 3 50  ? 142.005 108.961 106.292 1.00 17.20 ? 49  MET C O   1 
ATOM   6621 C CB  . MET C 3 50  ? 145.145 108.792 106.274 1.00 17.20 ? 49  MET C CB  1 
ATOM   6622 N N   . LEU C 3 51  ? 142.555 107.328 104.835 1.00 18.81 ? 50  LEU C N   1 
ATOM   6623 C CA  . LEU C 3 51  ? 141.309 106.599 105.009 1.00 18.81 ? 50  LEU C CA  1 
ATOM   6624 C C   . LEU C 3 51  ? 141.285 105.902 106.368 1.00 18.81 ? 50  LEU C C   1 
ATOM   6625 O O   . LEU C 3 51  ? 142.236 105.968 107.152 1.00 18.81 ? 50  LEU C O   1 
ATOM   6626 C CB  . LEU C 3 51  ? 141.118 105.592 103.877 1.00 18.81 ? 50  LEU C CB  1 
ATOM   6627 C CG  . LEU C 3 51  ? 140.637 106.128 102.526 1.00 18.81 ? 50  LEU C CG  1 
ATOM   6628 C CD1 . LEU C 3 51  ? 141.813 106.582 101.677 1.00 18.81 ? 50  LEU C CD1 1 
ATOM   6629 C CD2 . LEU C 3 51  ? 139.813 105.082 101.792 1.00 18.81 ? 50  LEU C CD2 1 
ATOM   6630 N N   . GLY C 3 52  ? 140.180 105.217 106.649 1.00 18.18 ? 51  GLY C N   1 
ATOM   6631 C CA  . GLY C 3 52  ? 140.028 104.504 107.902 1.00 18.18 ? 51  GLY C CA  1 
ATOM   6632 C C   . GLY C 3 52  ? 139.464 105.363 109.013 1.00 18.18 ? 51  GLY C C   1 
ATOM   6633 O O   . GLY C 3 52  ? 138.328 105.158 109.453 1.00 18.18 ? 51  GLY C O   1 
ATOM   6634 N N   . LYS C 3 53  ? 140.250 106.331 109.474 1.00 17.45 ? 52  LYS C N   1 
ATOM   6635 C CA  . LYS C 3 53  ? 139.801 107.228 110.527 1.00 17.45 ? 52  LYS C CA  1 
ATOM   6636 C C   . LYS C 3 53  ? 138.689 108.137 110.017 1.00 17.45 ? 52  LYS C C   1 
ATOM   6637 O O   . LYS C 3 53  ? 138.577 108.409 108.819 1.00 17.45 ? 52  LYS C O   1 
ATOM   6638 C CB  . LYS C 3 53  ? 140.970 108.066 111.042 1.00 17.45 ? 52  LYS C CB  1 
ATOM   6639 C CG  . LYS C 3 53  ? 142.066 107.251 111.705 1.00 17.45 ? 52  LYS C CG  1 
ATOM   6640 C CD  . LYS C 3 53  ? 143.164 108.144 112.254 1.00 17.45 ? 52  LYS C CD  1 
ATOM   6641 C CE  . LYS C 3 53  ? 143.970 108.770 111.130 1.00 17.45 ? 52  LYS C CE  1 
ATOM   6642 N NZ  . LYS C 3 53  ? 144.733 107.747 110.363 1.00 17.45 ? 52  LYS C NZ  1 
ATOM   6643 N N   . GLN C 3 54  ? 137.858 108.607 110.943 1.00 14.90 ? 53  GLN C N   1 
ATOM   6644 C CA  . GLN C 3 54  ? 136.706 109.444 110.608 1.00 14.90 ? 53  GLN C CA  1 
ATOM   6645 C C   . GLN C 3 54  ? 137.086 110.903 110.841 1.00 14.90 ? 53  GLN C C   1 
ATOM   6646 O O   . GLN C 3 54  ? 136.781 111.487 111.880 1.00 14.90 ? 53  GLN C O   1 
ATOM   6647 C CB  . GLN C 3 54  ? 135.486 109.041 111.429 1.00 14.90 ? 53  GLN C CB  1 
ATOM   6648 C CG  . GLN C 3 54  ? 134.181 109.693 110.983 1.00 14.90 ? 53  GLN C CG  1 
ATOM   6649 C CD  . GLN C 3 54  ? 133.854 110.957 111.759 1.00 14.90 ? 53  GLN C CD  1 
ATOM   6650 O OE1 . GLN C 3 54  ? 134.225 111.100 112.923 1.00 14.90 ? 53  GLN C OE1 1 
ATOM   6651 N NE2 . GLN C 3 54  ? 133.148 111.877 111.116 1.00 14.90 ? 53  GLN C NE2 1 
ATOM   6652 N N   . GLU C 3 55  ? 137.767 111.492 109.863 1.00 13.35 ? 54  GLU C N   1 
ATOM   6653 C CA  . GLU C 3 55  ? 138.004 112.928 109.846 1.00 13.35 ? 54  GLU C CA  1 
ATOM   6654 C C   . GLU C 3 55  ? 137.352 113.626 108.664 1.00 13.35 ? 54  GLU C C   1 
ATOM   6655 O O   . GLU C 3 55  ? 136.990 114.797 108.783 1.00 13.35 ? 54  GLU C O   1 
ATOM   6656 C CB  . GLU C 3 55  ? 139.511 113.232 109.852 1.00 13.35 ? 54  GLU C CB  1 
ATOM   6657 C CG  . GLU C 3 55  ? 140.234 112.908 108.559 1.00 13.35 ? 54  GLU C CG  1 
ATOM   6658 C CD  . GLU C 3 55  ? 140.892 111.546 108.587 1.00 13.35 ? 54  GLU C CD  1 
ATOM   6659 O OE1 . GLU C 3 55  ? 140.341 110.636 109.240 1.00 13.35 ? 54  GLU C OE1 1 
ATOM   6660 O OE2 . GLU C 3 55  ? 141.961 111.386 107.961 1.00 13.35 ? 54  GLU C OE2 1 
ATOM   6661 N N   . VAL C 3 56  ? 137.184 112.939 107.539 1.00 9.67  ? 55  VAL C N   1 
ATOM   6662 C CA  . VAL C 3 56  ? 136.404 113.438 106.424 1.00 9.67  ? 55  VAL C CA  1 
ATOM   6663 C C   . VAL C 3 56  ? 135.002 112.859 106.549 1.00 9.67  ? 55  VAL C C   1 
ATOM   6664 O O   . VAL C 3 56  ? 134.762 111.905 107.294 1.00 9.67  ? 55  VAL C O   1 
ATOM   6665 C CB  . VAL C 3 56  ? 137.041 113.072 105.065 1.00 9.67  ? 55  VAL C CB  1 
ATOM   6666 C CG1 . VAL C 3 56  ? 138.516 113.423 105.062 1.00 9.67  ? 55  VAL C CG1 1 
ATOM   6667 C CG2 . VAL C 3 56  ? 136.848 111.604 104.767 1.00 9.67  ? 55  VAL C CG2 1 
ATOM   6668 N N   . ILE C 3 57  ? 134.048 113.449 105.827 1.00 8.25  ? 56  ILE C N   1 
ATOM   6669 C CA  . ILE C 3 57  ? 132.697 112.907 105.853 1.00 8.25  ? 56  ILE C CA  1 
ATOM   6670 C C   . ILE C 3 57  ? 132.708 111.511 105.238 1.00 8.25  ? 56  ILE C C   1 
ATOM   6671 O O   . ILE C 3 57  ? 133.558 111.180 104.403 1.00 8.25  ? 56  ILE C O   1 
ATOM   6672 C CB  . ILE C 3 57  ? 131.698 113.823 105.126 1.00 8.25  ? 56  ILE C CB  1 
ATOM   6673 C CG1 . ILE C 3 57  ? 132.101 114.013 103.664 1.00 8.25  ? 56  ILE C CG1 1 
ATOM   6674 C CG2 . ILE C 3 57  ? 131.588 115.160 105.834 1.00 8.25  ? 56  ILE C CG2 1 
ATOM   6675 C CD1 . ILE C 3 57  ? 131.139 114.878 102.883 1.00 8.25  ? 56  ILE C CD1 1 
ATOM   6676 N N   . ARG C 3 58  ? 131.757 110.677 105.668 1.00 8.94  ? 57  ARG C N   1 
ATOM   6677 C CA  . ARG C 3 58  ? 131.730 109.289 105.216 1.00 8.94  ? 57  ARG C CA  1 
ATOM   6678 C C   . ARG C 3 58  ? 131.549 109.185 103.708 1.00 8.94  ? 57  ARG C C   1 
ATOM   6679 O O   . ARG C 3 58  ? 131.996 108.206 103.095 1.00 8.94  ? 57  ARG C O   1 
ATOM   6680 C CB  . ARG C 3 58  ? 130.619 108.525 105.937 1.00 8.94  ? 57  ARG C CB  1 
ATOM   6681 N N   . GLY C 3 59  ? 130.894 110.174 103.096 1.00 8.41  ? 58  GLY C N   1 
ATOM   6682 C CA  . GLY C 3 59  ? 130.739 110.160 101.651 1.00 8.41  ? 58  GLY C CA  1 
ATOM   6683 C C   . GLY C 3 59  ? 132.071 110.112 100.929 1.00 8.41  ? 58  GLY C C   1 
ATOM   6684 O O   . GLY C 3 59  ? 132.262 109.322 100.004 1.00 8.41  ? 58  GLY C O   1 
ATOM   6685 N N   . TRP C 3 60  ? 133.017 110.950 101.357 1.00 9.23  ? 59  TRP C N   1 
ATOM   6686 C CA  . TRP C 3 60  ? 134.360 110.907 100.790 1.00 9.23  ? 59  TRP C CA  1 
ATOM   6687 C C   . TRP C 3 60  ? 134.989 109.535 100.991 1.00 9.23  ? 59  TRP C C   1 
ATOM   6688 O O   . TRP C 3 60  ? 135.558 108.956 100.058 1.00 9.23  ? 59  TRP C O   1 
ATOM   6689 C CB  . TRP C 3 60  ? 135.237 111.983 101.432 1.00 9.23  ? 59  TRP C CB  1 
ATOM   6690 C CG  . TRP C 3 60  ? 135.210 113.314 100.755 1.00 9.23  ? 59  TRP C CG  1 
ATOM   6691 C CD1 . TRP C 3 60  ? 134.134 114.135 100.600 1.00 9.23  ? 59  TRP C CD1 1 
ATOM   6692 C CD2 . TRP C 3 60  ? 136.320 113.989 100.155 1.00 9.23  ? 59  TRP C CD2 1 
ATOM   6693 N NE1 . TRP C 3 60  ? 134.504 115.277 99.933  1.00 9.23  ? 59  TRP C NE1 1 
ATOM   6694 C CE2 . TRP C 3 60  ? 135.843 115.210 99.649  1.00 9.23  ? 59  TRP C CE2 1 
ATOM   6695 C CE3 . TRP C 3 60  ? 137.673 113.676 99.992  1.00 9.23  ? 59  TRP C CE3 1 
ATOM   6696 C CZ2 . TRP C 3 60  ? 136.668 116.118 98.993  1.00 9.23  ? 59  TRP C CZ2 1 
ATOM   6697 C CZ3 . TRP C 3 60  ? 138.491 114.579 99.341  1.00 9.23  ? 59  TRP C CZ3 1 
ATOM   6698 C CH2 . TRP C 3 60  ? 137.987 115.784 98.850  1.00 9.23  ? 59  TRP C CH2 1 
ATOM   6699 N N   . GLU C 3 61  ? 134.873 108.991 102.204 1.00 9.02  ? 60  GLU C N   1 
ATOM   6700 C CA  . GLU C 3 61  ? 135.556 107.745 102.535 1.00 9.02  ? 60  GLU C CA  1 
ATOM   6701 C C   . GLU C 3 61  ? 135.059 106.590 101.677 1.00 9.02  ? 60  GLU C C   1 
ATOM   6702 O O   . GLU C 3 61  ? 135.856 105.766 101.215 1.00 9.02  ? 60  GLU C O   1 
ATOM   6703 C CB  . GLU C 3 61  ? 135.376 107.429 104.020 1.00 9.02  ? 60  GLU C CB  1 
ATOM   6704 N N   . GLU C 3 62  ? 133.750 106.509 101.451 1.00 9.78  ? 61  GLU C N   1 
ATOM   6705 C CA  . GLU C 3 62  ? 133.200 105.420 100.653 1.00 9.78  ? 61  GLU C CA  1 
ATOM   6706 C C   . GLU C 3 62  ? 133.099 105.750 99.167  1.00 9.78  ? 61  GLU C C   1 
ATOM   6707 O O   . GLU C 3 62  ? 132.738 104.869 98.380  1.00 9.78  ? 61  GLU C O   1 
ATOM   6708 C CB  . GLU C 3 62  ? 131.825 105.005 101.188 1.00 9.78  ? 61  GLU C CB  1 
ATOM   6709 C CG  . GLU C 3 62  ? 130.731 106.029 100.984 1.00 9.78  ? 61  GLU C CG  1 
ATOM   6710 C CD  . GLU C 3 62  ? 129.376 105.523 101.431 1.00 9.78  ? 61  GLU C CD  1 
ATOM   6711 O OE1 . GLU C 3 62  ? 128.753 104.747 100.679 1.00 9.78  ? 61  GLU C OE1 1 
ATOM   6712 O OE2 . GLU C 3 62  ? 128.933 105.901 102.535 1.00 9.78  ? 61  GLU C OE2 1 
ATOM   6713 N N   . GLY C 3 63  ? 133.409 106.981 98.759  1.00 12.86 ? 62  GLY C N   1 
ATOM   6714 C CA  . GLY C 3 63  ? 133.393 107.317 97.349  1.00 12.86 ? 62  GLY C CA  1 
ATOM   6715 C C   . GLY C 3 63  ? 134.756 107.313 96.690  1.00 12.86 ? 62  GLY C C   1 
ATOM   6716 O O   . GLY C 3 63  ? 134.909 106.781 95.587  1.00 12.86 ? 62  GLY C O   1 
ATOM   6717 N N   . VAL C 3 64  ? 135.754 107.911 97.347  1.00 13.31 ? 63  VAL C N   1 
ATOM   6718 C CA  . VAL C 3 64  ? 137.100 107.940 96.782  1.00 13.31 ? 63  VAL C CA  1 
ATOM   6719 C C   . VAL C 3 64  ? 137.658 106.529 96.648  1.00 13.31 ? 63  VAL C C   1 
ATOM   6720 O O   . VAL C 3 64  ? 138.504 106.265 95.784  1.00 13.31 ? 63  VAL C O   1 
ATOM   6721 C CB  . VAL C 3 64  ? 138.016 108.844 97.634  1.00 13.31 ? 63  VAL C CB  1 
ATOM   6722 C CG1 . VAL C 3 64  ? 139.391 108.981 96.996  1.00 13.31 ? 63  VAL C CG1 1 
ATOM   6723 C CG2 . VAL C 3 64  ? 137.385 110.212 97.812  1.00 13.31 ? 63  VAL C CG2 1 
ATOM   6724 N N   . ALA C 3 65  ? 137.191 105.598 97.485  1.00 14.72 ? 64  ALA C N   1 
ATOM   6725 C CA  . ALA C 3 65  ? 137.632 104.213 97.369  1.00 14.72 ? 64  ALA C CA  1 
ATOM   6726 C C   . ALA C 3 65  ? 137.228 103.601 96.032  1.00 14.72 ? 64  ALA C C   1 
ATOM   6727 O O   . ALA C 3 65  ? 137.915 102.704 95.529  1.00 14.72 ? 64  ALA C O   1 
ATOM   6728 C CB  . ALA C 3 65  ? 137.071 103.385 98.523  1.00 14.72 ? 64  ALA C CB  1 
ATOM   6729 N N   . GLN C 3 66  ? 136.125 104.067 95.444  1.00 17.89 ? 65  GLN C N   1 
ATOM   6730 C CA  . GLN C 3 66  ? 135.681 103.573 94.147  1.00 17.89 ? 65  GLN C CA  1 
ATOM   6731 C C   . GLN C 3 66  ? 136.441 104.192 92.982  1.00 17.89 ? 65  GLN C C   1 
ATOM   6732 O O   . GLN C 3 66  ? 136.256 103.751 91.842  1.00 17.89 ? 65  GLN C O   1 
ATOM   6733 C CB  . GLN C 3 66  ? 134.183 103.833 93.966  1.00 17.89 ? 65  GLN C CB  1 
ATOM   6734 C CG  . GLN C 3 66  ? 133.308 103.264 95.069  1.00 17.89 ? 65  GLN C CG  1 
ATOM   6735 C CD  . GLN C 3 66  ? 131.843 103.611 94.885  1.00 17.89 ? 65  GLN C CD  1 
ATOM   6736 O OE1 . GLN C 3 66  ? 131.464 104.249 93.904  1.00 17.89 ? 65  GLN C OE1 1 
ATOM   6737 N NE2 . GLN C 3 66  ? 131.012 103.194 95.832  1.00 17.89 ? 65  GLN C NE2 1 
ATOM   6738 N N   . MET C 3 67  ? 137.284 105.190 93.233  1.00 20.71 ? 66  MET C N   1 
ATOM   6739 C CA  . MET C 3 67  ? 138.026 105.861 92.175  1.00 20.71 ? 66  MET C CA  1 
ATOM   6740 C C   . MET C 3 67  ? 139.234 105.023 91.761  1.00 20.71 ? 66  MET C C   1 
ATOM   6741 O O   . MET C 3 67  ? 139.376 103.853 92.129  1.00 20.71 ? 66  MET C O   1 
ATOM   6742 C CB  . MET C 3 67  ? 138.469 107.249 92.625  1.00 20.71 ? 66  MET C CB  1 
ATOM   6743 C CG  . MET C 3 67  ? 137.387 108.304 92.648  1.00 20.71 ? 66  MET C CG  1 
ATOM   6744 S SD  . MET C 3 67  ? 138.139 109.943 92.635  1.00 20.71 ? 66  MET C SD  1 
ATOM   6745 C CE  . MET C 3 67  ? 136.842 110.925 93.368  1.00 20.71 ? 66  MET C CE  1 
ATOM   6746 N N   . SER C 3 68  ? 140.121 105.631 90.976  1.00 22.49 ? 67  SER C N   1 
ATOM   6747 C CA  . SER C 3 68  ? 141.393 105.037 90.598  1.00 22.49 ? 67  SER C CA  1 
ATOM   6748 C C   . SER C 3 68  ? 142.466 106.113 90.695  1.00 22.49 ? 67  SER C C   1 
ATOM   6749 O O   . SER C 3 68  ? 142.187 107.269 91.027  1.00 22.49 ? 67  SER C O   1 
ATOM   6750 C CB  . SER C 3 68  ? 141.330 104.432 89.190  1.00 22.49 ? 67  SER C CB  1 
ATOM   6751 O OG  . SER C 3 68  ? 141.107 105.435 88.215  1.00 22.49 ? 67  SER C OG  1 
ATOM   6752 N N   . VAL C 3 69  ? 143.704 105.730 90.403  1.00 21.95 ? 68  VAL C N   1 
ATOM   6753 C CA  . VAL C 3 69  ? 144.826 106.659 90.473  1.00 21.95 ? 68  VAL C CA  1 
ATOM   6754 C C   . VAL C 3 69  ? 144.805 107.564 89.248  1.00 21.95 ? 68  VAL C C   1 
ATOM   6755 O O   . VAL C 3 69  ? 144.643 107.095 88.115  1.00 21.95 ? 68  VAL C O   1 
ATOM   6756 C CB  . VAL C 3 69  ? 146.157 105.899 90.586  1.00 21.95 ? 68  VAL C CB  1 
ATOM   6757 C CG1 . VAL C 3 69  ? 147.332 106.847 90.407  1.00 21.95 ? 68  VAL C CG1 1 
ATOM   6758 C CG2 . VAL C 3 69  ? 146.244 105.197 91.929  1.00 21.95 ? 68  VAL C CG2 1 
ATOM   6759 N N   . GLY C 3 70  ? 144.960 108.864 89.475  1.00 19.72 ? 69  GLY C N   1 
ATOM   6760 C CA  . GLY C 3 70  ? 144.984 109.831 88.390  1.00 19.72 ? 69  GLY C CA  1 
ATOM   6761 C C   . GLY C 3 70  ? 143.680 109.949 87.633  1.00 19.72 ? 69  GLY C C   1 
ATOM   6762 O O   . GLY C 3 70  ? 143.693 110.111 86.407  1.00 19.72 ? 69  GLY C O   1 
ATOM   6763 N N   . GLN C 3 71  ? 142.553 109.873 88.334  1.00 19.88 ? 70  GLN C N   1 
ATOM   6764 C CA  . GLN C 3 71  ? 141.234 109.953 87.723  1.00 19.88 ? 70  GLN C CA  1 
ATOM   6765 C C   . GLN C 3 71  ? 140.479 111.141 88.300  1.00 19.88 ? 70  GLN C C   1 
ATOM   6766 O O   . GLN C 3 71  ? 140.344 111.261 89.522  1.00 19.88 ? 70  GLN C O   1 
ATOM   6767 C CB  . GLN C 3 71  ? 140.444 108.661 87.951  1.00 19.88 ? 70  GLN C CB  1 
ATOM   6768 C CG  . GLN C 3 71  ? 138.953 108.789 87.682  1.00 19.88 ? 70  GLN C CG  1 
ATOM   6769 C CD  . GLN C 3 71  ? 138.194 107.516 87.995  1.00 19.88 ? 70  GLN C CD  1 
ATOM   6770 O OE1 . GLN C 3 71  ? 136.967 107.518 88.084  1.00 19.88 ? 70  GLN C OE1 1 
ATOM   6771 N NE2 . GLN C 3 71  ? 138.921 106.420 88.162  1.00 19.88 ? 70  GLN C NE2 1 
ATOM   6772 N N   . ARG C 3 72  ? 139.989 112.010 87.422  1.00 14.51 ? 71  ARG C N   1 
ATOM   6773 C CA  . ARG C 3 72  ? 139.181 113.149 87.830  1.00 14.51 ? 71  ARG C CA  1 
ATOM   6774 C C   . ARG C 3 72  ? 137.713 112.833 87.580  1.00 14.51 ? 71  ARG C C   1 
ATOM   6775 O O   . ARG C 3 72  ? 137.325 112.509 86.451  1.00 14.51 ? 71  ARG C O   1 
ATOM   6776 C CB  . ARG C 3 72  ? 139.600 114.406 87.069  1.00 14.51 ? 71  ARG C CB  1 
ATOM   6777 C CG  . ARG C 3 72  ? 138.914 115.681 87.522  1.00 14.51 ? 71  ARG C CG  1 
ATOM   6778 C CD  . ARG C 3 72  ? 139.502 116.895 86.822  1.00 14.51 ? 71  ARG C CD  1 
ATOM   6779 N NE  . ARG C 3 72  ? 138.807 118.126 87.185  1.00 14.51 ? 71  ARG C NE  1 
ATOM   6780 C CZ  . ARG C 3 72  ? 137.737 118.592 86.549  1.00 14.51 ? 71  ARG C CZ  1 
ATOM   6781 N NH1 . ARG C 3 72  ? 137.234 117.928 85.518  1.00 14.51 ? 71  ARG C NH1 1 
ATOM   6782 N NH2 . ARG C 3 72  ? 137.167 119.721 86.948  1.00 14.51 ? 71  ARG C NH2 1 
ATOM   6783 N N   . ALA C 3 73  ? 136.902 112.934 88.633  1.00 10.82 ? 72  ALA C N   1 
ATOM   6784 C CA  . ALA C 3 73  ? 135.514 112.504 88.588  1.00 10.82 ? 72  ALA C CA  1 
ATOM   6785 C C   . ALA C 3 73  ? 134.641 113.486 89.356  1.00 10.82 ? 72  ALA C C   1 
ATOM   6786 O O   . ALA C 3 73  ? 135.114 114.492 89.888  1.00 10.82 ? 72  ALA C O   1 
ATOM   6787 C CB  . ALA C 3 73  ? 135.350 111.091 89.156  1.00 10.82 ? 72  ALA C CB  1 
ATOM   6788 N N   . LYS C 3 74  ? 133.348 113.175 89.406  1.00 8.53  ? 73  LYS C N   1 
ATOM   6789 C CA  . LYS C 3 74  ? 132.349 113.990 90.083  1.00 8.53  ? 73  LYS C CA  1 
ATOM   6790 C C   . LYS C 3 74  ? 131.654 113.167 91.156  1.00 8.53  ? 73  LYS C C   1 
ATOM   6791 O O   . LYS C 3 74  ? 131.450 111.962 90.993  1.00 8.53  ? 73  LYS C O   1 
ATOM   6792 C CB  . LYS C 3 74  ? 131.308 114.527 89.098  1.00 8.53  ? 73  LYS C CB  1 
ATOM   6793 C CG  . LYS C 3 74  ? 131.710 115.803 88.385  1.00 8.53  ? 73  LYS C CG  1 
ATOM   6794 C CD  . LYS C 3 74  ? 130.764 116.104 87.235  1.00 8.53  ? 73  LYS C CD  1 
ATOM   6795 C CE  . LYS C 3 74  ? 129.367 116.422 87.740  1.00 8.53  ? 73  LYS C CE  1 
ATOM   6796 N NZ  . LYS C 3 74  ? 128.436 116.749 86.625  1.00 8.53  ? 73  LYS C NZ  1 
ATOM   6797 N N   . LEU C 3 75  ? 131.289 113.826 92.251  1.00 6.42  ? 74  LEU C N   1 
ATOM   6798 C CA  . LEU C 3 75  ? 130.597 113.198 93.366  1.00 6.42  ? 74  LEU C CA  1 
ATOM   6799 C C   . LEU C 3 75  ? 129.346 113.996 93.689  1.00 6.42  ? 74  LEU C C   1 
ATOM   6800 O O   . LEU C 3 75  ? 129.348 115.226 93.594  1.00 6.42  ? 74  LEU C O   1 
ATOM   6801 C CB  . LEU C 3 75  ? 131.479 113.132 94.617  1.00 6.42  ? 74  LEU C CB  1 
ATOM   6802 C CG  . LEU C 3 75  ? 132.585 112.090 94.741  1.00 6.42  ? 74  LEU C CG  1 
ATOM   6803 C CD1 . LEU C 3 75  ? 133.711 112.394 93.788  1.00 6.42  ? 74  LEU C CD1 1 
ATOM   6804 C CD2 . LEU C 3 75  ? 133.098 112.078 96.163  1.00 6.42  ? 74  LEU C CD2 1 
ATOM   6805 N N   . THR C 3 76  ? 128.290 113.300 94.095  1.00 3.91  ? 75  THR C N   1 
ATOM   6806 C CA  . THR C 3 76  ? 127.066 113.934 94.576  1.00 3.91  ? 75  THR C CA  1 
ATOM   6807 C C   . THR C 3 76  ? 126.741 113.313 95.929  1.00 3.91  ? 75  THR C C   1 
ATOM   6808 O O   . THR C 3 76  ? 126.029 112.311 96.014  1.00 3.91  ? 75  THR C O   1 
ATOM   6809 C CB  . THR C 3 76  ? 125.924 113.768 93.589  1.00 3.91  ? 75  THR C CB  1 
ATOM   6810 O OG1 . THR C 3 76  ? 126.347 114.211 92.294  1.00 3.91  ? 75  THR C OG1 1 
ATOM   6811 C CG2 . THR C 3 76  ? 124.723 114.591 94.030  1.00 3.91  ? 75  THR C CG2 1 
ATOM   6812 N N   . ILE C 3 77  ? 127.261 113.922 96.988  1.00 5.89  ? 76  ILE C N   1 
ATOM   6813 C CA  . ILE C 3 77  ? 127.095 113.401 98.340  1.00 5.89  ? 76  ILE C CA  1 
ATOM   6814 C C   . ILE C 3 77  ? 125.724 113.812 98.862  1.00 5.89  ? 76  ILE C C   1 
ATOM   6815 O O   . ILE C 3 77  ? 125.405 115.004 98.938  1.00 5.89  ? 76  ILE C O   1 
ATOM   6816 C CB  . ILE C 3 77  ? 128.212 113.900 99.266  1.00 5.89  ? 76  ILE C CB  1 
ATOM   6817 C CG1 . ILE C 3 77  ? 129.554 113.909 98.533  1.00 5.89  ? 76  ILE C CG1 1 
ATOM   6818 C CG2 . ILE C 3 77  ? 128.293 113.036 100.504 1.00 5.89  ? 76  ILE C CG2 1 
ATOM   6819 C CD1 . ILE C 3 77  ? 130.009 112.557 98.064  1.00 5.89  ? 76  ILE C CD1 1 
ATOM   6820 N N   . SER C 3 78  ? 124.915 112.822 99.222  1.00 8.87  ? 77  SER C N   1 
ATOM   6821 C CA  . SER C 3 78  ? 123.581 113.056 99.737  1.00 8.87  ? 77  SER C CA  1 
ATOM   6822 C C   . SER C 3 78  ? 123.657 113.626 101.152 1.00 8.87  ? 77  SER C C   1 
ATOM   6823 O O   . SER C 3 78  ? 124.696 113.539 101.810 1.00 8.87  ? 77  SER C O   1 
ATOM   6824 C CB  . SER C 3 78  ? 122.791 111.747 99.719  1.00 8.87  ? 77  SER C CB  1 
ATOM   6825 O OG  . SER C 3 78  ? 121.515 111.869 100.318 1.00 8.87  ? 77  SER C OG  1 
ATOM   6826 N N   . PRO C 3 79  ? 122.576 114.245 101.633 1.00 11.68 ? 78  PRO C N   1 
ATOM   6827 C CA  . PRO C 3 79  ? 122.565 114.715 103.028 1.00 11.68 ? 78  PRO C CA  1 
ATOM   6828 C C   . PRO C 3 79  ? 122.781 113.617 104.056 1.00 11.68 ? 78  PRO C C   1 
ATOM   6829 O O   . PRO C 3 79  ? 123.208 113.924 105.175 1.00 11.68 ? 78  PRO C O   1 
ATOM   6830 C CB  . PRO C 3 79  ? 121.174 115.342 103.174 1.00 11.68 ? 78  PRO C CB  1 
ATOM   6831 C CG  . PRO C 3 79  ? 120.839 115.803 101.810 1.00 11.68 ? 78  PRO C CG  1 
ATOM   6832 C CD  . PRO C 3 79  ? 121.468 114.825 100.854 1.00 11.68 ? 78  PRO C CD  1 
ATOM   6833 N N   . ASP C 3 80  ? 122.492 112.356 103.724 1.00 11.44 ? 79  ASP C N   1 
ATOM   6834 C CA  . ASP C 3 80  ? 122.678 111.274 104.688 1.00 11.44 ? 79  ASP C CA  1 
ATOM   6835 C C   . ASP C 3 80  ? 124.135 111.169 105.123 1.00 11.44 ? 79  ASP C C   1 
ATOM   6836 O O   . ASP C 3 80  ? 124.434 111.074 106.319 1.00 11.44 ? 79  ASP C O   1 
ATOM   6837 C CB  . ASP C 3 80  ? 122.202 109.950 104.090 1.00 11.44 ? 79  ASP C CB  1 
ATOM   6838 C CG  . ASP C 3 80  ? 120.693 109.857 104.003 1.00 11.44 ? 79  ASP C CG  1 
ATOM   6839 O OD1 . ASP C 3 80  ? 120.021 110.085 105.031 1.00 11.44 ? 79  ASP C OD1 1 
ATOM   6840 O OD2 . ASP C 3 80  ? 120.178 109.551 102.907 1.00 11.44 ? 79  ASP C OD2 1 
ATOM   6841 N N   . TYR C 3 81  ? 125.057 111.195 104.164 1.00 10.20 ? 80  TYR C N   1 
ATOM   6842 C CA  . TYR C 3 81  ? 126.483 111.113 104.443 1.00 10.20 ? 80  TYR C CA  1 
ATOM   6843 C C   . TYR C 3 81  ? 127.146 112.481 104.475 1.00 10.20 ? 80  TYR C C   1 
ATOM   6844 O O   . TYR C 3 81  ? 128.376 112.563 104.540 1.00 10.20 ? 80  TYR C O   1 
ATOM   6845 C CB  . TYR C 3 81  ? 127.171 110.218 103.412 1.00 10.20 ? 80  TYR C CB  1 
ATOM   6846 C CG  . TYR C 3 81  ? 126.559 108.839 103.303 1.00 10.20 ? 80  TYR C CG  1 
ATOM   6847 C CD1 . TYR C 3 81  ? 125.985 108.223 104.408 1.00 10.20 ? 80  TYR C CD1 1 
ATOM   6848 C CD2 . TYR C 3 81  ? 126.555 108.152 102.098 1.00 10.20 ? 80  TYR C CD2 1 
ATOM   6849 C CE1 . TYR C 3 81  ? 125.424 106.964 104.314 1.00 10.20 ? 80  TYR C CE1 1 
ATOM   6850 C CE2 . TYR C 3 81  ? 125.998 106.891 101.996 1.00 10.20 ? 80  TYR C CE2 1 
ATOM   6851 C CZ  . TYR C 3 81  ? 125.434 106.303 103.106 1.00 10.20 ? 80  TYR C CZ  1 
ATOM   6852 O OH  . TYR C 3 81  ? 124.878 105.050 103.007 1.00 10.20 ? 80  TYR C OH  1 
ATOM   6853 N N   . ALA C 3 82  ? 126.362 113.551 104.423 1.00 9.28  ? 81  ALA C N   1 
ATOM   6854 C CA  . ALA C 3 82  ? 126.875 114.911 104.491 1.00 9.28  ? 81  ALA C CA  1 
ATOM   6855 C C   . ALA C 3 82  ? 126.942 115.344 105.956 1.00 9.28  ? 81  ALA C C   1 
ATOM   6856 O O   . ALA C 3 82  ? 126.847 114.517 106.866 1.00 9.28  ? 81  ALA C O   1 
ATOM   6857 C CB  . ALA C 3 82  ? 126.007 115.839 103.638 1.00 9.28  ? 81  ALA C CB  1 
ATOM   6858 N N   . TYR C 3 83  ? 127.103 116.636 106.200 1.00 9.44  ? 82  TYR C N   1 
ATOM   6859 C CA  . TYR C 3 83  ? 127.215 117.179 107.551 1.00 9.44  ? 82  TYR C CA  1 
ATOM   6860 C C   . TYR C 3 83  ? 125.924 117.054 108.360 1.00 9.44  ? 82  TYR C C   1 
ATOM   6861 O O   . TYR C 3 83  ? 125.862 117.595 109.471 1.00 9.44  ? 82  TYR C O   1 
ATOM   6862 C CB  . TYR C 3 83  ? 127.674 118.637 107.483 1.00 9.44  ? 82  TYR C CB  1 
ATOM   6863 C CG  . TYR C 3 83  ? 129.078 118.778 106.943 1.00 9.44  ? 82  TYR C CG  1 
ATOM   6864 C CD1 . TYR C 3 83  ? 129.328 118.703 105.583 1.00 9.44  ? 82  TYR C CD1 1 
ATOM   6865 C CD2 . TYR C 3 83  ? 130.154 118.960 107.794 1.00 9.44  ? 82  TYR C CD2 1 
ATOM   6866 C CE1 . TYR C 3 83  ? 130.607 118.815 105.086 1.00 9.44  ? 82  TYR C CE1 1 
ATOM   6867 C CE2 . TYR C 3 83  ? 131.438 119.073 107.304 1.00 9.44  ? 82  TYR C CE2 1 
ATOM   6868 C CZ  . TYR C 3 83  ? 131.657 119.000 105.949 1.00 9.44  ? 82  TYR C CZ  1 
ATOM   6869 O OH  . TYR C 3 83  ? 132.931 119.111 105.451 1.00 9.44  ? 82  TYR C OH  1 
ATOM   6870 N N   . GLY C 3 84  ? 124.902 116.374 107.850 1.00 11.45 ? 83  GLY C N   1 
ATOM   6871 C CA  . GLY C 3 84  ? 123.744 116.049 108.654 1.00 11.45 ? 83  GLY C CA  1 
ATOM   6872 C C   . GLY C 3 84  ? 122.763 117.199 108.780 1.00 11.45 ? 83  GLY C C   1 
ATOM   6873 O O   . GLY C 3 84  ? 122.819 118.198 108.058 1.00 11.45 ? 83  GLY C O   1 
ATOM   6874 N N   . ALA C 3 85  ? 121.837 117.036 109.726 1.00 14.58 ? 84  ALA C N   1 
ATOM   6875 C CA  . ALA C 3 85  ? 120.804 118.043 109.935 1.00 14.58 ? 84  ALA C CA  1 
ATOM   6876 C C   . ALA C 3 85  ? 121.392 119.349 110.456 1.00 14.58 ? 84  ALA C C   1 
ATOM   6877 O O   . ALA C 3 85  ? 120.930 120.433 110.083 1.00 14.58 ? 84  ALA C O   1 
ATOM   6878 C CB  . ALA C 3 85  ? 119.741 117.513 110.896 1.00 14.58 ? 84  ALA C CB  1 
ATOM   6879 N N   . THR C 3 86  ? 122.401 119.269 111.326 1.00 14.09 ? 85  THR C N   1 
ATOM   6880 C CA  . THR C 3 86  ? 122.969 120.486 111.898 1.00 14.09 ? 85  THR C CA  1 
ATOM   6881 C C   . THR C 3 86  ? 123.710 121.309 110.849 1.00 14.09 ? 85  THR C C   1 
ATOM   6882 O O   . THR C 3 86  ? 123.534 122.530 110.777 1.00 14.09 ? 85  THR C O   1 
ATOM   6883 C CB  . THR C 3 86  ? 123.885 120.142 113.078 1.00 14.09 ? 85  THR C CB  1 
ATOM   6884 O OG1 . THR C 3 86  ? 124.515 121.336 113.562 1.00 14.09 ? 85  THR C OG1 1 
ATOM   6885 C CG2 . THR C 3 86  ? 124.947 119.116 112.688 1.00 14.09 ? 85  THR C CG2 1 
ATOM   6886 N N   . GLY C 3 87  ? 124.536 120.666 110.027 1.00 13.17 ? 86  GLY C N   1 
ATOM   6887 C CA  . GLY C 3 87  ? 125.292 121.376 109.015 1.00 13.17 ? 86  GLY C CA  1 
ATOM   6888 C C   . GLY C 3 87  ? 126.468 122.143 109.584 1.00 13.17 ? 86  GLY C C   1 
ATOM   6889 O O   . GLY C 3 87  ? 126.383 122.691 110.687 1.00 13.17 ? 86  GLY C O   1 
ATOM   6890 N N   . HIS C 3 88  ? 127.569 122.190 108.846 1.00 8.62  ? 87  HIS C N   1 
ATOM   6891 C CA  . HIS C 3 88  ? 128.717 122.974 109.274 1.00 8.62  ? 87  HIS C CA  1 
ATOM   6892 C C   . HIS C 3 88  ? 128.330 124.447 109.328 1.00 8.62  ? 87  HIS C C   1 
ATOM   6893 O O   . HIS C 3 88  ? 127.775 124.971 108.353 1.00 8.62  ? 87  HIS C O   1 
ATOM   6894 C CB  . HIS C 3 88  ? 129.888 122.773 108.312 1.00 8.62  ? 87  HIS C CB  1 
ATOM   6895 C CG  . HIS C 3 88  ? 131.195 123.297 108.822 1.00 8.62  ? 87  HIS C CG  1 
ATOM   6896 N ND1 . HIS C 3 88  ? 131.382 124.613 109.182 1.00 8.62  ? 87  HIS C ND1 1 
ATOM   6897 C CD2 . HIS C 3 88  ? 132.386 122.683 109.012 1.00 8.62  ? 87  HIS C CD2 1 
ATOM   6898 C CE1 . HIS C 3 88  ? 132.627 124.785 109.585 1.00 8.62  ? 87  HIS C CE1 1 
ATOM   6899 N NE2 . HIS C 3 88  ? 133.258 123.629 109.491 1.00 8.62  ? 87  HIS C NE2 1 
ATOM   6900 N N   . PRO C 3 89  ? 128.579 125.139 110.437 1.00 7.19  ? 88  PRO C N   1 
ATOM   6901 C CA  . PRO C 3 89  ? 128.301 126.578 110.476 1.00 7.19  ? 88  PRO C CA  1 
ATOM   6902 C C   . PRO C 3 89  ? 129.192 127.332 109.502 1.00 7.19  ? 88  PRO C C   1 
ATOM   6903 O O   . PRO C 3 89  ? 130.345 126.965 109.267 1.00 7.19  ? 88  PRO C O   1 
ATOM   6904 C CB  . PRO C 3 89  ? 128.605 126.961 111.928 1.00 7.19  ? 88  PRO C CB  1 
ATOM   6905 C CG  . PRO C 3 89  ? 129.543 125.911 112.404 1.00 7.19  ? 88  PRO C CG  1 
ATOM   6906 C CD  . PRO C 3 89  ? 129.138 124.648 111.705 1.00 7.19  ? 88  PRO C CD  1 
ATOM   6907 N N   . GLY C 3 90  ? 128.645 128.405 108.940 1.00 6.36  ? 89  GLY C N   1 
ATOM   6908 C CA  . GLY C 3 90  ? 129.368 129.207 107.975 1.00 6.36  ? 89  GLY C CA  1 
ATOM   6909 C C   . GLY C 3 90  ? 129.107 128.865 106.522 1.00 6.36  ? 89  GLY C C   1 
ATOM   6910 O O   . GLY C 3 90  ? 128.548 129.688 105.794 1.00 6.36  ? 89  GLY C O   1 
ATOM   6911 N N   . ILE C 3 91  ? 129.487 127.669 106.075 1.00 6.92  ? 90  ILE C N   1 
ATOM   6912 C CA  . ILE C 3 91  ? 129.332 127.334 104.663 1.00 6.92  ? 90  ILE C CA  1 
ATOM   6913 C C   . ILE C 3 91  ? 128.036 126.583 104.395 1.00 6.92  ? 90  ILE C C   1 
ATOM   6914 O O   . ILE C 3 91  ? 127.133 127.105 103.731 1.00 6.92  ? 90  ILE C O   1 
ATOM   6915 C CB  . ILE C 3 91  ? 130.520 126.505 104.142 1.00 6.92  ? 90  ILE C CB  1 
ATOM   6916 C CG1 . ILE C 3 91  ? 131.826 127.278 104.221 1.00 6.92  ? 90  ILE C CG1 1 
ATOM   6917 C CG2 . ILE C 3 91  ? 130.278 126.108 102.712 1.00 6.92  ? 90  ILE C CG2 1 
ATOM   6918 C CD1 . ILE C 3 91  ? 131.849 128.491 103.348 1.00 6.92  ? 90  ILE C CD1 1 
ATOM   6919 N N   . ILE C 3 92  ? 127.926 125.366 104.917 1.00 9.11  ? 91  ILE C N   1 
ATOM   6920 C CA  . ILE C 3 92  ? 126.932 124.403 104.453 1.00 9.11  ? 91  ILE C CA  1 
ATOM   6921 C C   . ILE C 3 92  ? 125.640 124.629 105.233 1.00 9.11  ? 91  ILE C C   1 
ATOM   6922 O O   . ILE C 3 92  ? 125.653 124.525 106.468 1.00 9.11  ? 91  ILE C O   1 
ATOM   6923 C CB  . ILE C 3 92  ? 127.417 122.957 104.611 1.00 9.11  ? 91  ILE C CB  1 
ATOM   6924 C CG1 . ILE C 3 92  ? 128.657 122.688 103.755 1.00 9.11  ? 91  ILE C CG1 1 
ATOM   6925 C CG2 . ILE C 3 92  ? 126.311 121.989 104.246 1.00 9.11  ? 91  ILE C CG2 1 
ATOM   6926 C CD1 . ILE C 3 92  ? 129.956 122.984 104.445 1.00 9.11  ? 91  ILE C CD1 1 
ATOM   6927 N N   . PRO C 3 93  ? 124.527 124.919 104.568 1.00 14.02 ? 92  PRO C N   1 
ATOM   6928 C CA  . PRO C 3 93  ? 123.251 125.050 105.269 1.00 14.02 ? 92  PRO C CA  1 
ATOM   6929 C C   . PRO C 3 93  ? 122.722 123.688 105.679 1.00 14.02 ? 92  PRO C C   1 
ATOM   6930 O O   . PRO C 3 93  ? 123.219 122.655 105.207 1.00 14.02 ? 92  PRO C O   1 
ATOM   6931 C CB  . PRO C 3 93  ? 122.344 125.709 104.220 1.00 14.02 ? 92  PRO C CB  1 
ATOM   6932 C CG  . PRO C 3 93  ? 122.903 125.254 102.920 1.00 14.02 ? 92  PRO C CG  1 
ATOM   6933 C CD  . PRO C 3 93  ? 124.391 125.131 103.117 1.00 14.02 ? 92  PRO C CD  1 
ATOM   6934 N N   . PRO C 3 94  ? 121.733 123.638 106.570 1.00 17.79 ? 93  PRO C N   1 
ATOM   6935 C CA  . PRO C 3 94  ? 121.129 122.348 106.922 1.00 17.79 ? 93  PRO C CA  1 
ATOM   6936 C C   . PRO C 3 94  ? 120.468 121.695 105.716 1.00 17.79 ? 93  PRO C C   1 
ATOM   6937 O O   . PRO C 3 94  ? 119.893 122.370 104.859 1.00 17.79 ? 93  PRO C O   1 
ATOM   6938 C CB  . PRO C 3 94  ? 120.099 122.719 107.995 1.00 17.79 ? 93  PRO C CB  1 
ATOM   6939 C CG  . PRO C 3 94  ? 120.563 124.027 108.536 1.00 17.79 ? 93  PRO C CG  1 
ATOM   6940 C CD  . PRO C 3 94  ? 121.196 124.741 107.385 1.00 17.79 ? 93  PRO C CD  1 
ATOM   6941 N N   . HIS C 3 95  ? 120.556 120.367 105.662 1.00 18.75 ? 94  HIS C N   1 
ATOM   6942 C CA  . HIS C 3 95  ? 119.938 119.557 104.610 1.00 18.75 ? 94  HIS C CA  1 
ATOM   6943 C C   . HIS C 3 95  ? 120.411 119.998 103.225 1.00 18.75 ? 94  HIS C C   1 
ATOM   6944 O O   . HIS C 3 95  ? 119.618 120.309 102.335 1.00 18.75 ? 94  HIS C O   1 
ATOM   6945 C CB  . HIS C 3 95  ? 118.410 119.612 104.702 1.00 18.75 ? 94  HIS C CB  1 
ATOM   6946 C CG  . HIS C 3 95  ? 117.872 119.394 106.081 1.00 18.75 ? 94  HIS C CG  1 
ATOM   6947 N ND1 . HIS C 3 95  ? 118.570 118.716 107.057 1.00 18.75 ? 94  HIS C ND1 1 
ATOM   6948 C CD2 . HIS C 3 95  ? 116.700 119.766 106.648 1.00 18.75 ? 94  HIS C CD2 1 
ATOM   6949 C CE1 . HIS C 3 95  ? 117.852 118.680 108.165 1.00 18.75 ? 94  HIS C CE1 1 
ATOM   6950 N NE2 . HIS C 3 95  ? 116.713 119.310 107.943 1.00 18.75 ? 94  HIS C NE2 1 
ATOM   6951 N N   . ALA C 3 96  ? 121.729 120.018 103.052 1.00 13.29 ? 95  ALA C N   1 
ATOM   6952 C CA  . ALA C 3 96  ? 122.349 120.517 101.831 1.00 13.29 ? 95  ALA C CA  1 
ATOM   6953 C C   . ALA C 3 96  ? 123.070 119.384 101.114 1.00 13.29 ? 95  ALA C C   1 
ATOM   6954 O O   . ALA C 3 96  ? 124.056 118.847 101.628 1.00 13.29 ? 95  ALA C O   1 
ATOM   6955 C CB  . ALA C 3 96  ? 123.321 121.655 102.136 1.00 13.29 ? 95  ALA C CB  1 
ATOM   6956 N N   . THR C 3 97  ? 122.579 119.032 99.930  1.00 8.87  ? 96  THR C N   1 
ATOM   6957 C CA  . THR C 3 97  ? 123.282 118.088 99.075  1.00 8.87  ? 96  THR C CA  1 
ATOM   6958 C C   . THR C 3 97  ? 124.588 118.704 98.595  1.00 8.87  ? 96  THR C C   1 
ATOM   6959 O O   . THR C 3 97  ? 124.633 119.878 98.220  1.00 8.87  ? 96  THR C O   1 
ATOM   6960 C CB  . THR C 3 97  ? 122.409 117.705 97.880  1.00 8.87  ? 96  THR C CB  1 
ATOM   6961 O OG1 . THR C 3 97  ? 121.197 117.099 98.345  1.00 8.87  ? 96  THR C OG1 1 
ATOM   6962 C CG2 . THR C 3 97  ? 123.139 116.729 96.972  1.00 8.87  ? 96  THR C CG2 1 
ATOM   6963 N N   . LEU C 3 98  ? 125.655 117.914 98.609  1.00 7.14  ? 97  LEU C N   1 
ATOM   6964 C CA  . LEU C 3 98  ? 126.974 118.398 98.232  1.00 7.14  ? 97  LEU C CA  1 
ATOM   6965 C C   . LEU C 3 98  ? 127.366 117.845 96.870  1.00 7.14  ? 97  LEU C C   1 
ATOM   6966 O O   . LEU C 3 98  ? 126.985 116.734 96.503  1.00 7.14  ? 97  LEU C O   1 
ATOM   6967 C CB  . LEU C 3 98  ? 128.026 118.006 99.271  1.00 7.14  ? 97  LEU C CB  1 
ATOM   6968 C CG  . LEU C 3 98  ? 128.349 119.013 100.373 1.00 7.14  ? 97  LEU C CG  1 
ATOM   6969 C CD1 . LEU C 3 98  ? 127.083 119.568 100.988 1.00 7.14  ? 97  LEU C CD1 1 
ATOM   6970 C CD2 . LEU C 3 98  ? 129.208 118.368 101.438 1.00 7.14  ? 97  LEU C CD2 1 
ATOM   6971 N N   . VAL C 3 99  ? 128.126 118.635 96.121  1.00 4.75  ? 98  VAL C N   1 
ATOM   6972 C CA  . VAL C 3 99  ? 128.660 118.228 94.828  1.00 4.75  ? 98  VAL C CA  1 
ATOM   6973 C C   . VAL C 3 99  ? 130.155 118.498 94.841  1.00 4.75  ? 98  VAL C C   1 
ATOM   6974 O O   . VAL C 3 99  ? 130.586 119.590 95.221  1.00 4.75  ? 98  VAL C O   1 
ATOM   6975 C CB  . VAL C 3 99  ? 127.985 118.976 93.663  1.00 4.75  ? 98  VAL C CB  1 
ATOM   6976 C CG1 . VAL C 3 99  ? 128.666 118.635 92.347  1.00 4.75  ? 98  VAL C CG1 1 
ATOM   6977 C CG2 . VAL C 3 99  ? 126.503 118.651 93.605  1.00 4.75  ? 98  VAL C CG2 1 
ATOM   6978 N N   . PHE C 3 100 ? 130.944 117.515 94.431  1.00 10.41 ? 99  PHE C N   1 
ATOM   6979 C CA  . PHE C 3 100 ? 132.391 117.624 94.505  1.00 10.41 ? 99  PHE C CA  1 
ATOM   6980 C C   . PHE C 3 100 ? 133.013 117.233 93.175  1.00 10.41 ? 99  PHE C C   1 
ATOM   6981 O O   . PHE C 3 100 ? 132.425 116.492 92.385  1.00 10.41 ? 99  PHE C O   1 
ATOM   6982 C CB  . PHE C 3 100 ? 132.958 116.752 95.627  1.00 10.41 ? 99  PHE C CB  1 
ATOM   6983 C CG  . PHE C 3 100 ? 132.827 117.361 96.991  1.00 10.41 ? 99  PHE C CG  1 
ATOM   6984 C CD1 . PHE C 3 100 ? 131.599 117.420 97.621  1.00 10.41 ? 99  PHE C CD1 1 
ATOM   6985 C CD2 . PHE C 3 100 ? 133.933 117.864 97.649  1.00 10.41 ? 99  PHE C CD2 1 
ATOM   6986 C CE1 . PHE C 3 100 ? 131.476 117.977 98.872  1.00 10.41 ? 99  PHE C CE1 1 
ATOM   6987 C CE2 . PHE C 3 100 ? 133.813 118.421 98.902  1.00 10.41 ? 99  PHE C CE2 1 
ATOM   6988 C CZ  . PHE C 3 100 ? 132.582 118.475 99.514  1.00 10.41 ? 99  PHE C CZ  1 
ATOM   6989 N N   . ASP C 3 101 ? 134.225 117.728 92.948  1.00 8.93  ? 100 ASP C N   1 
ATOM   6990 C CA  . ASP C 3 101 ? 134.974 117.520 91.714  1.00 8.93  ? 100 ASP C CA  1 
ATOM   6991 C C   . ASP C 3 101 ? 136.403 117.106 92.043  1.00 8.93  ? 100 ASP C C   1 
ATOM   6992 O O   . ASP C 3 101 ? 137.380 117.618 91.494  1.00 8.93  ? 100 ASP C O   1 
ATOM   6993 C CB  . ASP C 3 101 ? 134.924 118.787 90.860  1.00 8.93  ? 100 ASP C CB  1 
ATOM   6994 C CG  . ASP C 3 101 ? 135.558 118.607 89.494  1.00 8.93  ? 100 ASP C CG  1 
ATOM   6995 O OD1 . ASP C 3 101 ? 134.938 117.951 88.631  1.00 8.93  ? 100 ASP C OD1 1 
ATOM   6996 O OD2 . ASP C 3 101 ? 136.671 119.132 89.281  1.00 8.93  ? 100 ASP C OD2 1 
ATOM   6997 N N   . VAL C 3 102 ? 136.533 116.160 92.974  1.00 9.45  ? 101 VAL C N   1 
ATOM   6998 C CA  . VAL C 3 102 ? 137.845 115.768 93.468  1.00 9.45  ? 101 VAL C CA  1 
ATOM   6999 C C   . VAL C 3 102 ? 138.671 115.138 92.348  1.00 9.45  ? 101 VAL C C   1 
ATOM   7000 O O   . VAL C 3 102 ? 138.136 114.528 91.415  1.00 9.45  ? 101 VAL C O   1 
ATOM   7001 C CB  . VAL C 3 102 ? 137.686 114.798 94.650  1.00 9.45  ? 101 VAL C CB  1 
ATOM   7002 C CG1 . VAL C 3 102 ? 139.006 114.604 95.377  1.00 9.45  ? 101 VAL C CG1 1 
ATOM   7003 C CG2 . VAL C 3 102 ? 136.612 115.304 95.596  1.00 9.45  ? 101 VAL C CG2 1 
ATOM   7004 N N   . GLU C 3 103 ? 139.990 115.300 92.435  1.00 11.40 ? 102 GLU C N   1 
ATOM   7005 C CA  . GLU C 3 103 ? 140.917 114.720 91.466  1.00 11.40 ? 102 GLU C CA  1 
ATOM   7006 C C   . GLU C 3 103 ? 142.128 114.189 92.219  1.00 11.40 ? 102 GLU C C   1 
ATOM   7007 O O   . GLU C 3 103 ? 142.914 114.971 92.762  1.00 11.40 ? 102 GLU C O   1 
ATOM   7008 C CB  . GLU C 3 103 ? 141.335 115.748 90.414  1.00 11.40 ? 102 GLU C CB  1 
ATOM   7009 N N   . LEU C 3 104 ? 142.281 112.867 92.250  1.00 17.27 ? 103 LEU C N   1 
ATOM   7010 C CA  . LEU C 3 104 ? 143.403 112.257 92.950  1.00 17.27 ? 103 LEU C CA  1 
ATOM   7011 C C   . LEU C 3 104 ? 144.715 112.545 92.229  1.00 17.27 ? 103 LEU C C   1 
ATOM   7012 O O   . LEU C 3 104 ? 144.802 112.453 91.002  1.00 17.27 ? 103 LEU C O   1 
ATOM   7013 C CB  . LEU C 3 104 ? 143.193 110.748 93.076  1.00 17.27 ? 103 LEU C CB  1 
ATOM   7014 C CG  . LEU C 3 104 ? 144.385 109.900 93.532  1.00 17.27 ? 103 LEU C CG  1 
ATOM   7015 C CD1 . LEU C 3 104 ? 144.876 110.330 94.906  1.00 17.27 ? 103 LEU C CD1 1 
ATOM   7016 C CD2 . LEU C 3 104 ? 144.015 108.429 93.540  1.00 17.27 ? 103 LEU C CD2 1 
ATOM   7017 N N   . LEU C 3 105 ? 145.742 112.898 93.003  1.00 19.95 ? 104 LEU C N   1 
ATOM   7018 C CA  . LEU C 3 105 ? 147.059 113.193 92.450  1.00 19.95 ? 104 LEU C CA  1 
ATOM   7019 C C   . LEU C 3 105 ? 148.114 112.191 92.898  1.00 19.95 ? 104 LEU C C   1 
ATOM   7020 O O   . LEU C 3 105 ? 148.765 111.574 92.050  1.00 19.95 ? 104 LEU C O   1 
ATOM   7021 C CB  . LEU C 3 105 ? 147.486 114.616 92.831  1.00 19.95 ? 104 LEU C CB  1 
ATOM   7022 C CG  . LEU C 3 105 ? 146.856 115.763 92.043  1.00 19.95 ? 104 LEU C CG  1 
ATOM   7023 C CD1 . LEU C 3 105 ? 147.490 117.078 92.448  1.00 19.95 ? 104 LEU C CD1 1 
ATOM   7024 C CD2 . LEU C 3 105 ? 146.998 115.531 90.547  1.00 19.95 ? 104 LEU C CD2 1 
ATOM   7025 N N   . LYS C 3 106 ? 148.308 112.007 94.204  1.00 21.57 ? 105 LYS C N   1 
ATOM   7026 C CA  . LYS C 3 106 ? 149.402 111.183 94.699  1.00 21.57 ? 105 LYS C CA  1 
ATOM   7027 C C   . LYS C 3 106 ? 148.920 110.284 95.828  1.00 21.57 ? 105 LYS C C   1 
ATOM   7028 O O   . LYS C 3 106 ? 147.912 110.556 96.485  1.00 21.57 ? 105 LYS C O   1 
ATOM   7029 C CB  . LYS C 3 106 ? 150.584 112.034 95.187  1.00 21.57 ? 105 LYS C CB  1 
ATOM   7030 C CG  . LYS C 3 106 ? 151.154 112.982 94.146  1.00 21.57 ? 105 LYS C CG  1 
ATOM   7031 C CD  . LYS C 3 106 ? 152.312 113.788 94.710  1.00 21.57 ? 105 LYS C CD  1 
ATOM   7032 C CE  . LYS C 3 106 ? 152.904 114.714 93.659  1.00 21.57 ? 105 LYS C CE  1 
ATOM   7033 N NZ  . LYS C 3 106 ? 154.018 115.536 94.207  1.00 21.57 ? 105 LYS C NZ  1 
ATOM   7034 N N   . LEU C 3 107 ? 149.663 109.202 96.046  1.00 19.53 ? 106 LEU C N   1 
ATOM   7035 C CA  . LEU C 3 107 ? 149.413 108.268 97.137  1.00 19.53 ? 106 LEU C CA  1 
ATOM   7036 C C   . LEU C 3 107 ? 150.626 108.268 98.056  1.00 19.53 ? 106 LEU C C   1 
ATOM   7037 O O   . LEU C 3 107 ? 151.748 108.017 97.603  1.00 19.53 ? 106 LEU C O   1 
ATOM   7038 C CB  . LEU C 3 107 ? 149.138 106.860 96.606  1.00 19.53 ? 106 LEU C CB  1 
ATOM   7039 C CG  . LEU C 3 107 ? 147.676 106.489 96.354  1.00 19.53 ? 106 LEU C CG  1 
ATOM   7040 C CD1 . LEU C 3 107 ? 147.146 107.205 95.122  1.00 19.53 ? 106 LEU C CD1 1 
ATOM   7041 C CD2 . LEU C 3 107 ? 147.524 104.983 96.208  1.00 19.53 ? 106 LEU C CD2 1 
ATOM   7042 N N   . GLU C 3 108 ? 150.396 108.545 99.337  1.00 18.98 ? 107 GLU C N   1 
ATOM   7043 C CA  . GLU C 3 108 ? 151.462 108.615 100.337 1.00 18.98 ? 107 GLU C CA  1 
ATOM   7044 C C   . GLU C 3 108 ? 152.575 109.570 99.914  1.00 18.98 ? 107 GLU C C   1 
ATOM   7045 C CB  . GLU C 3 108 ? 152.040 107.223 100.608 1.00 18.98 ? 107 GLU C CB  1 
ATOM   7046 C CG  . GLU C 3 108 ? 151.096 106.294 101.353 1.00 18.98 ? 107 GLU C CG  1 
ATOM   7047 C CD  . GLU C 3 108 ? 151.810 105.100 101.956 1.00 18.98 ? 107 GLU C CD  1 
ATOM   7048 O OE1 . GLU C 3 108 ? 153.057 105.056 101.890 1.00 18.98 ? 107 GLU C OE1 1 
ATOM   7049 O OE2 . GLU C 3 108 ? 151.126 104.207 102.498 1.00 18.98 ? 107 GLU C OE2 1 
ATOM   7050 O OXT . GLU C 3 108 ? 153.388 110.002 100.731 1.00 18.98 ? 107 GLU C OXT 1 
HETATM 7051 O O17 . CAU D 4 .   ? 137.554 143.784 170.498 1.00 11.12 ? 501 CAU A O17 1 
HETATM 7052 C C16 . CAU D 4 .   ? 137.121 143.213 171.700 1.00 11.12 ? 501 CAU A C16 1 
HETATM 7053 C C18 . CAU D 4 .   ? 136.629 144.339 172.608 1.00 11.12 ? 501 CAU A C18 1 
HETATM 7054 N N19 . CAU D 4 .   ? 137.759 144.979 173.254 1.00 11.12 ? 501 CAU A N19 1 
HETATM 7055 C C20 . CAU D 4 .   ? 137.282 145.985 174.183 1.00 11.12 ? 501 CAU A C20 1 
HETATM 7056 C C21 . CAU D 4 .   ? 137.491 147.367 173.572 1.00 11.12 ? 501 CAU A C21 1 
HETATM 7057 C C22 . CAU D 4 .   ? 138.020 145.835 175.511 1.00 11.12 ? 501 CAU A C22 1 
HETATM 7058 C C15 . CAU D 4 .   ? 136.027 142.194 171.382 1.00 11.12 ? 501 CAU A C15 1 
HETATM 7059 O O14 . CAU D 4 .   ? 134.994 142.373 172.312 1.00 11.12 ? 501 CAU A O14 1 
HETATM 7060 C C13 . CAU D 4 .   ? 133.715 142.034 171.857 1.00 11.12 ? 501 CAU A C13 1 
HETATM 7061 C C12 . CAU D 4 .   ? 133.490 141.749 170.514 1.00 11.12 ? 501 CAU A C12 1 
HETATM 7062 C C11 . CAU D 4 .   ? 132.206 141.417 170.081 1.00 11.12 ? 501 CAU A C11 1 
HETATM 7063 C C10 . CAU D 4 .   ? 131.151 141.375 170.980 1.00 11.12 ? 501 CAU A C10 1 
HETATM 7064 C C8  . CAU D 4 .   ? 131.382 141.669 172.345 1.00 11.12 ? 501 CAU A C8  1 
HETATM 7065 C C9  . CAU D 4 .   ? 132.643 141.993 172.773 1.00 11.12 ? 501 CAU A C9  1 
HETATM 7066 N N7  . CAU D 4 .   ? 130.535 141.695 173.403 1.00 11.12 ? 501 CAU A N7  1 
HETATM 7067 C C3  . CAU D 4 .   ? 131.214 142.032 174.526 1.00 11.12 ? 501 CAU A C3  1 
HETATM 7068 C C4  . CAU D 4 .   ? 132.533 142.230 174.203 1.00 11.12 ? 501 CAU A C4  1 
HETATM 7069 C C2  . CAU D 4 .   ? 130.780 142.190 175.866 1.00 11.12 ? 501 CAU A C2  1 
HETATM 7070 C C1  . CAU D 4 .   ? 131.693 142.545 176.849 1.00 11.12 ? 501 CAU A C1  1 
HETATM 7071 C C6  . CAU D 4 .   ? 133.035 142.747 176.520 1.00 11.12 ? 501 CAU A C6  1 
HETATM 7072 C C5  . CAU D 4 .   ? 133.461 142.591 175.203 1.00 11.12 ? 501 CAU A C5  1 
HETATM 7073 C C1  . FK5 E 5 .   ? 135.810 117.500 105.328 1.00 10.41 ? 201 FK5 C C1  1 
HETATM 7074 C C2  . FK5 E 5 .   ? 135.420 117.759 103.898 1.00 10.41 ? 201 FK5 C C2  1 
HETATM 7075 C C3  . FK5 E 5 .   ? 135.945 116.636 103.014 1.00 10.41 ? 201 FK5 C C3  1 
HETATM 7076 C C4  . FK5 E 5 .   ? 137.455 116.725 102.858 1.00 10.41 ? 201 FK5 C C4  1 
HETATM 7077 C C5  . FK5 E 5 .   ? 137.856 118.058 102.252 1.00 10.41 ? 201 FK5 C C5  1 
HETATM 7078 C C6  . FK5 E 5 .   ? 137.368 119.206 103.122 1.00 10.41 ? 201 FK5 C C6  1 
HETATM 7079 C C8  . FK5 E 5 .   ? 135.077 120.033 103.197 1.00 10.41 ? 201 FK5 C C8  1 
HETATM 7080 C C9  . FK5 E 5 .   ? 135.506 121.272 102.717 1.00 10.41 ? 201 FK5 C C9  1 
HETATM 7081 C C10 . FK5 E 5 .   ? 135.871 122.399 103.674 1.00 10.41 ? 201 FK5 C C10 1 
HETATM 7082 C C11 . FK5 E 5 .   ? 134.873 122.411 104.828 1.00 10.41 ? 201 FK5 C C11 1 
HETATM 7083 C C12 . FK5 E 5 .   ? 135.336 123.252 106.008 1.00 10.41 ? 201 FK5 C C12 1 
HETATM 7084 C C13 . FK5 E 5 .   ? 136.809 123.032 106.302 1.00 10.41 ? 201 FK5 C C13 1 
HETATM 7085 C C14 . FK5 E 5 .   ? 137.593 123.243 105.019 1.00 10.41 ? 201 FK5 C C14 1 
HETATM 7086 C C15 . FK5 E 5 .   ? 139.111 123.237 105.199 1.00 10.41 ? 201 FK5 C C15 1 
HETATM 7087 C C16 . FK5 E 5 .   ? 139.592 122.044 106.010 1.00 10.41 ? 201 FK5 C C16 1 
HETATM 7088 C C17 . FK5 E 5 .   ? 141.098 121.810 105.919 1.00 10.41 ? 201 FK5 C C17 1 
HETATM 7089 C C18 . FK5 E 5 .   ? 141.814 122.454 107.100 1.00 10.41 ? 201 FK5 C C18 1 
HETATM 7090 C C19 . FK5 E 5 .   ? 141.477 121.741 108.391 1.00 10.41 ? 201 FK5 C C19 1 
HETATM 7091 C C20 . FK5 E 5 .   ? 140.604 122.392 109.383 1.00 10.41 ? 201 FK5 C C20 1 
HETATM 7092 C C21 . FK5 E 5 .   ? 139.965 121.634 110.503 1.00 10.41 ? 201 FK5 C C21 1 
HETATM 7093 C C22 . FK5 E 5 .   ? 138.560 121.312 110.117 1.00 10.41 ? 201 FK5 C C22 1 
HETATM 7094 C C23 . FK5 E 5 .   ? 138.275 120.522 108.865 1.00 10.41 ? 201 FK5 C C23 1 
HETATM 7095 C C24 . FK5 E 5 .   ? 138.324 119.008 109.044 1.00 10.41 ? 201 FK5 C C24 1 
HETATM 7096 C C25 . FK5 E 5 .   ? 138.214 118.334 107.681 1.00 10.41 ? 201 FK5 C C25 1 
HETATM 7097 C C26 . FK5 E 5 .   ? 136.810 117.850 107.300 1.00 10.41 ? 201 FK5 C C26 1 
HETATM 7098 C C27 . FK5 E 5 .   ? 135.712 118.327 108.217 1.00 10.41 ? 201 FK5 C C27 1 
HETATM 7099 C C28 . FK5 E 5 .   ? 135.310 117.550 109.400 1.00 10.41 ? 201 FK5 C C28 1 
HETATM 7100 C C29 . FK5 E 5 .   ? 133.925 117.718 109.951 1.00 10.41 ? 201 FK5 C C29 1 
HETATM 7101 C C30 . FK5 E 5 .   ? 133.324 116.362 110.303 1.00 10.41 ? 201 FK5 C C30 1 
HETATM 7102 C C31 . FK5 E 5 .   ? 131.905 116.535 110.836 1.00 10.41 ? 201 FK5 C C31 1 
HETATM 7103 C C32 . FK5 E 5 .   ? 131.864 117.480 112.031 1.00 10.41 ? 201 FK5 C C32 1 
HETATM 7104 C C33 . FK5 E 5 .   ? 132.529 118.808 111.698 1.00 10.41 ? 201 FK5 C C33 1 
HETATM 7105 C C34 . FK5 E 5 .   ? 133.951 118.578 111.206 1.00 10.41 ? 201 FK5 C C34 1 
HETATM 7106 C C35 . FK5 E 5 .   ? 133.529 122.924 104.334 1.00 10.41 ? 201 FK5 C C35 1 
HETATM 7107 C C36 . FK5 E 5 .   ? 141.669 122.318 104.603 1.00 10.41 ? 201 FK5 C C36 1 
HETATM 7108 C C37 . FK5 E 5 .   ? 142.041 120.381 108.662 1.00 10.41 ? 201 FK5 C C37 1 
HETATM 7109 C C38 . FK5 E 5 .   ? 139.870 122.505 111.746 1.00 10.41 ? 201 FK5 C C38 1 
HETATM 7110 C C39 . FK5 E 5 .   ? 141.233 122.913 112.244 1.00 10.41 ? 201 FK5 C C39 1 
HETATM 7111 C C40 . FK5 E 5 .   ? 141.682 124.298 112.083 1.00 10.41 ? 201 FK5 C C40 1 
HETATM 7112 C C41 . FK5 E 5 .   ? 139.227 117.201 107.569 1.00 10.41 ? 201 FK5 C C41 1 
HETATM 7113 C C42 . FK5 E 5 .   ? 134.976 119.597 107.913 1.00 10.41 ? 201 FK5 C C42 1 
HETATM 7114 C C43 . FK5 E 5 .   ? 136.529 123.690 108.503 1.00 10.41 ? 201 FK5 C C43 1 
HETATM 7115 C C44 . FK5 E 5 .   ? 139.720 125.478 104.916 1.00 10.41 ? 201 FK5 C C44 1 
HETATM 7116 C C45 . FK5 E 5 .   ? 130.570 114.740 110.180 1.00 10.41 ? 201 FK5 C C45 1 
HETATM 7117 N N7  . FK5 E 5 .   ? 135.936 119.039 103.405 1.00 10.41 ? 201 FK5 C N7  1 
HETATM 7118 O O1  . FK5 E 5 .   ? 136.546 118.281 105.975 1.00 10.41 ? 201 FK5 C O1  1 
HETATM 7119 O O2  . FK5 E 5 .   ? 135.325 116.343 105.966 1.00 10.41 ? 201 FK5 C O2  1 
HETATM 7120 O O3  . FK5 E 5 .   ? 133.711 119.795 103.454 1.00 10.41 ? 201 FK5 C O3  1 
HETATM 7121 O O4  . FK5 E 5 .   ? 135.595 121.490 101.328 1.00 10.41 ? 201 FK5 C O4  1 
HETATM 7122 O O5  . FK5 E 5 .   ? 137.196 122.221 104.135 1.00 10.41 ? 201 FK5 C O5  1 
HETATM 7123 O O6  . FK5 E 5 .   ? 135.781 123.660 102.966 1.00 10.41 ? 201 FK5 C O6  1 
HETATM 7124 O O7  . FK5 E 5 .   ? 137.199 123.949 107.290 1.00 10.41 ? 201 FK5 C O7  1 
HETATM 7125 O O8  . FK5 E 5 .   ? 139.514 124.428 105.837 1.00 10.41 ? 201 FK5 C O8  1 
HETATM 7126 O O9  . FK5 E 5 .   ? 137.501 121.791 110.910 1.00 10.41 ? 201 FK5 C O9  1 
HETATM 7127 O O10 . FK5 E 5 .   ? 139.541 118.621 109.636 1.00 10.41 ? 201 FK5 C O10 1 
HETATM 7128 O O11 . FK5 E 5 .   ? 131.370 115.284 111.204 1.00 10.41 ? 201 FK5 C O11 1 
HETATM 7129 O O12 . FK5 E 5 .   ? 130.520 117.712 112.386 1.00 10.41 ? 201 FK5 C O12 1 
# 
