data_9CFQ
# 
_entry.id   9CFQ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9CFQ         pdb_00009cfq 10.2210/pdb9cfq/pdb 
WWPDB D_1000285417 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9CFQ 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 9CEI unspecified 
PDB . 9CFI unspecified 
PDB . 9CFM unspecified 
PDB . 9CFO unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              mwilson13@unl.edu 
_pdbx_contact_author.name_first         Mark 
_pdbx_contact_author.name_last          Wilson 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6317-900X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zielinski, K.'  1  ? 
'Dolamore, C.'   2  ? 
'Dalton, K.'     3  ? 
'Meisburger, S.' 4  ? 
'Smith, N.'      5  ? 
'Termini, J.'    6  ? 
'Henning, R.'    7  ? 
'Srajer, V.'     8  ? 
'Hekstra, D.'    9  ? 
'Pollack, L.'    10 ? 
'Wilson, M.A.'   11 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2024.07.19.604369 
_citation.pdbx_database_id_PubMed   39071394 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zielinski, K.A.' 1  ?                   
primary 'Dolamore, C.'    2  ?                   
primary 'Dalton, K.M.'    3  ?                   
primary 'Smith, N.'       4  ?                   
primary 'Termini, J.'     5  ?                   
primary 'Henning, R.'     6  ?                   
primary 'Srajer, V.'      7  ?                   
primary 'Hekstra, D.R.'   8  ?                   
primary 'Pollack, L.'     9  0000-0002-9366-4396 
primary 'Wilson, M.A.'    10 0000-0001-6317-900X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer man 'Parkinson disease protein 7' 20215.328 1   3.1.2.-,3.5.1.-,3.5.1.124 ? ? 
;GSHMASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPY DVVVLPGGNLGAQNLSESAAVKEILKEQENRKGLIAAI(CSO)AGPTALLAHEIGFGSKVTTHPLAKDKMMNGG HYTYSENRVEKDGLILTSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
;
2 water   nat water                         18.015    136 ?                         ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
'Maillard deglycase,Oncogene DJ1,Parkinsonism-associated deglycase,Protein DJ-1,DJ-1,Protein/nucleic acid deglycase DJ-1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       
;GSHMASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNL
GAQNLSESAAVKEILKEQENRKGLIAAI(CSO)AGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLIL
TSRGPGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSHMASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNL
GAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRG
PGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
_pdbx_entity_nonpoly.entity_id   2 
_pdbx_entity_nonpoly.name        water 
_pdbx_entity_nonpoly.comp_id     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   HIS n 
1 4   MET n 
1 5   ALA n 
1 6   SER n 
1 7   LYS n 
1 8   ARG n 
1 9   ALA n 
1 10  LEU n 
1 11  VAL n 
1 12  ILE n 
1 13  LEU n 
1 14  ALA n 
1 15  LYS n 
1 16  GLY n 
1 17  ALA n 
1 18  GLU n 
1 19  GLU n 
1 20  MET n 
1 21  GLU n 
1 22  THR n 
1 23  VAL n 
1 24  ILE n 
1 25  PRO n 
1 26  VAL n 
1 27  ASP n 
1 28  VAL n 
1 29  MET n 
1 30  ARG n 
1 31  ARG n 
1 32  ALA n 
1 33  GLY n 
1 34  ILE n 
1 35  LYS n 
1 36  VAL n 
1 37  THR n 
1 38  VAL n 
1 39  ALA n 
1 40  GLY n 
1 41  LEU n 
1 42  ALA n 
1 43  GLY n 
1 44  LYS n 
1 45  ASP n 
1 46  PRO n 
1 47  VAL n 
1 48  GLN n 
1 49  CYS n 
1 50  SER n 
1 51  ARG n 
1 52  ASP n 
1 53  VAL n 
1 54  VAL n 
1 55  ILE n 
1 56  CYS n 
1 57  PRO n 
1 58  ASP n 
1 59  ALA n 
1 60  SER n 
1 61  LEU n 
1 62  GLU n 
1 63  ASP n 
1 64  ALA n 
1 65  LYS n 
1 66  LYS n 
1 67  GLU n 
1 68  GLY n 
1 69  PRO n 
1 70  TYR n 
1 71  ASP n 
1 72  VAL n 
1 73  VAL n 
1 74  VAL n 
1 75  LEU n 
1 76  PRO n 
1 77  GLY n 
1 78  GLY n 
1 79  ASN n 
1 80  LEU n 
1 81  GLY n 
1 82  ALA n 
1 83  GLN n 
1 84  ASN n 
1 85  LEU n 
1 86  SER n 
1 87  GLU n 
1 88  SER n 
1 89  ALA n 
1 90  ALA n 
1 91  VAL n 
1 92  LYS n 
1 93  GLU n 
1 94  ILE n 
1 95  LEU n 
1 96  LYS n 
1 97  GLU n 
1 98  GLN n 
1 99  GLU n 
1 100 ASN n 
1 101 ARG n 
1 102 LYS n 
1 103 GLY n 
1 104 LEU n 
1 105 ILE n 
1 106 ALA n 
1 107 ALA n 
1 108 ILE n 
1 109 CSO n 
1 110 ALA n 
1 111 GLY n 
1 112 PRO n 
1 113 THR n 
1 114 ALA n 
1 115 LEU n 
1 116 LEU n 
1 117 ALA n 
1 118 HIS n 
1 119 GLU n 
1 120 ILE n 
1 121 GLY n 
1 122 PHE n 
1 123 GLY n 
1 124 SER n 
1 125 LYS n 
1 126 VAL n 
1 127 THR n 
1 128 THR n 
1 129 HIS n 
1 130 PRO n 
1 131 LEU n 
1 132 ALA n 
1 133 LYS n 
1 134 ASP n 
1 135 LYS n 
1 136 MET n 
1 137 MET n 
1 138 ASN n 
1 139 GLY n 
1 140 GLY n 
1 141 HIS n 
1 142 TYR n 
1 143 THR n 
1 144 TYR n 
1 145 SER n 
1 146 GLU n 
1 147 ASN n 
1 148 ARG n 
1 149 VAL n 
1 150 GLU n 
1 151 LYS n 
1 152 ASP n 
1 153 GLY n 
1 154 LEU n 
1 155 ILE n 
1 156 LEU n 
1 157 THR n 
1 158 SER n 
1 159 ARG n 
1 160 GLY n 
1 161 PRO n 
1 162 GLY n 
1 163 THR n 
1 164 SER n 
1 165 PHE n 
1 166 GLU n 
1 167 PHE n 
1 168 ALA n 
1 169 LEU n 
1 170 ALA n 
1 171 ILE n 
1 172 VAL n 
1 173 GLU n 
1 174 ALA n 
1 175 LEU n 
1 176 ASN n 
1 177 GLY n 
1 178 LYS n 
1 179 GLU n 
1 180 VAL n 
1 181 ALA n 
1 182 ALA n 
1 183 GLN n 
1 184 VAL n 
1 185 LYS n 
1 186 ALA n 
1 187 PRO n 
1 188 LEU n 
1 189 VAL n 
1 190 LEU n 
1 191 LYS n 
1 192 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   192 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PARK7 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          Plasmid 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET-15b 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE           ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE          ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE        ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'   ? 'C4 H7 N O4'     133.103 
CSO 'L-peptide linking' n S-HYDROXYCYSTEINE ? 'C3 H7 N O3 S'   137.158 
CYS 'L-peptide linking' y CYSTEINE          ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE         ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'   ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE           ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE         ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER             ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE        ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE           ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE            ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE        ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE     ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE           ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE            ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE         ? 'C4 H9 N O3'     119.119 
TYR 'L-peptide linking' y TYROSINE          ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE            ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -2  ?   ?   ?   A . n 
A 1 2   SER 2   -1  ?   ?   ?   A . n 
A 1 3   HIS 3   0   ?   ?   ?   A . n 
A 1 4   MET 4   1   ?   ?   ?   A . n 
A 1 5   ALA 5   2   2   ALA ALA A . n 
A 1 6   SER 6   3   3   SER SER A . n 
A 1 7   LYS 7   4   4   LYS LYS A . n 
A 1 8   ARG 8   5   5   ARG ARG A . n 
A 1 9   ALA 9   6   6   ALA ALA A . n 
A 1 10  LEU 10  7   7   LEU LEU A . n 
A 1 11  VAL 11  8   8   VAL VAL A . n 
A 1 12  ILE 12  9   9   ILE ILE A . n 
A 1 13  LEU 13  10  10  LEU LEU A . n 
A 1 14  ALA 14  11  11  ALA ALA A . n 
A 1 15  LYS 15  12  12  LYS LYS A . n 
A 1 16  GLY 16  13  13  GLY GLY A . n 
A 1 17  ALA 17  14  14  ALA ALA A . n 
A 1 18  GLU 18  15  15  GLU GLU A . n 
A 1 19  GLU 19  16  16  GLU GLU A . n 
A 1 20  MET 20  17  17  MET MET A . n 
A 1 21  GLU 21  18  18  GLU GLU A . n 
A 1 22  THR 22  19  19  THR THR A . n 
A 1 23  VAL 23  20  20  VAL VAL A . n 
A 1 24  ILE 24  21  21  ILE ILE A . n 
A 1 25  PRO 25  22  22  PRO PRO A . n 
A 1 26  VAL 26  23  23  VAL VAL A . n 
A 1 27  ASP 27  24  24  ASP ASP A . n 
A 1 28  VAL 28  25  25  VAL VAL A . n 
A 1 29  MET 29  26  26  MET MET A . n 
A 1 30  ARG 30  27  27  ARG ARG A . n 
A 1 31  ARG 31  28  28  ARG ARG A . n 
A 1 32  ALA 32  29  29  ALA ALA A . n 
A 1 33  GLY 33  30  30  GLY GLY A . n 
A 1 34  ILE 34  31  31  ILE ILE A . n 
A 1 35  LYS 35  32  32  LYS LYS A . n 
A 1 36  VAL 36  33  33  VAL VAL A . n 
A 1 37  THR 37  34  34  THR THR A . n 
A 1 38  VAL 38  35  35  VAL VAL A . n 
A 1 39  ALA 39  36  36  ALA ALA A . n 
A 1 40  GLY 40  37  37  GLY GLY A . n 
A 1 41  LEU 41  38  38  LEU LEU A . n 
A 1 42  ALA 42  39  39  ALA ALA A . n 
A 1 43  GLY 43  40  40  GLY GLY A . n 
A 1 44  LYS 44  41  41  LYS LYS A . n 
A 1 45  ASP 45  42  42  ASP ASP A . n 
A 1 46  PRO 46  43  43  PRO PRO A . n 
A 1 47  VAL 47  44  44  VAL VAL A . n 
A 1 48  GLN 48  45  45  GLN GLN A . n 
A 1 49  CYS 49  46  46  CYS CYS A . n 
A 1 50  SER 50  47  47  SER SER A . n 
A 1 51  ARG 51  48  48  ARG ARG A . n 
A 1 52  ASP 52  49  49  ASP ASP A . n 
A 1 53  VAL 53  50  50  VAL VAL A . n 
A 1 54  VAL 54  51  51  VAL VAL A . n 
A 1 55  ILE 55  52  52  ILE ILE A . n 
A 1 56  CYS 56  53  53  CYS CYS A . n 
A 1 57  PRO 57  54  54  PRO PRO A . n 
A 1 58  ASP 58  55  55  ASP ASP A . n 
A 1 59  ALA 59  56  56  ALA ALA A . n 
A 1 60  SER 60  57  57  SER SER A . n 
A 1 61  LEU 61  58  58  LEU LEU A . n 
A 1 62  GLU 62  59  59  GLU GLU A . n 
A 1 63  ASP 63  60  60  ASP ASP A . n 
A 1 64  ALA 64  61  61  ALA ALA A . n 
A 1 65  LYS 65  62  62  LYS LYS A . n 
A 1 66  LYS 66  63  63  LYS LYS A . n 
A 1 67  GLU 67  64  64  GLU GLU A . n 
A 1 68  GLY 68  65  65  GLY GLY A . n 
A 1 69  PRO 69  66  66  PRO PRO A . n 
A 1 70  TYR 70  67  67  TYR TYR A . n 
A 1 71  ASP 71  68  68  ASP ASP A . n 
A 1 72  VAL 72  69  69  VAL VAL A . n 
A 1 73  VAL 73  70  70  VAL VAL A . n 
A 1 74  VAL 74  71  71  VAL VAL A . n 
A 1 75  LEU 75  72  72  LEU LEU A . n 
A 1 76  PRO 76  73  73  PRO PRO A . n 
A 1 77  GLY 77  74  74  GLY GLY A . n 
A 1 78  GLY 78  75  75  GLY GLY A . n 
A 1 79  ASN 79  76  76  ASN ASN A . n 
A 1 80  LEU 80  77  77  LEU LEU A . n 
A 1 81  GLY 81  78  78  GLY GLY A . n 
A 1 82  ALA 82  79  79  ALA ALA A . n 
A 1 83  GLN 83  80  80  GLN GLN A . n 
A 1 84  ASN 84  81  81  ASN ASN A . n 
A 1 85  LEU 85  82  82  LEU LEU A . n 
A 1 86  SER 86  83  83  SER SER A . n 
A 1 87  GLU 87  84  84  GLU GLU A . n 
A 1 88  SER 88  85  85  SER SER A . n 
A 1 89  ALA 89  86  86  ALA ALA A . n 
A 1 90  ALA 90  87  87  ALA ALA A . n 
A 1 91  VAL 91  88  88  VAL VAL A . n 
A 1 92  LYS 92  89  89  LYS LYS A . n 
A 1 93  GLU 93  90  90  GLU GLU A . n 
A 1 94  ILE 94  91  91  ILE ILE A . n 
A 1 95  LEU 95  92  92  LEU LEU A . n 
A 1 96  LYS 96  93  93  LYS LYS A . n 
A 1 97  GLU 97  94  94  GLU GLU A . n 
A 1 98  GLN 98  95  95  GLN GLN A . n 
A 1 99  GLU 99  96  96  GLU GLU A . n 
A 1 100 ASN 100 97  97  ASN ASN A . n 
A 1 101 ARG 101 98  98  ARG ARG A . n 
A 1 102 LYS 102 99  99  LYS LYS A . n 
A 1 103 GLY 103 100 100 GLY GLY A . n 
A 1 104 LEU 104 101 101 LEU LEU A . n 
A 1 105 ILE 105 102 102 ILE ILE A . n 
A 1 106 ALA 106 103 103 ALA ALA A . n 
A 1 107 ALA 107 104 104 ALA ALA A . n 
A 1 108 ILE 108 105 105 ILE ILE A . n 
A 1 109 CSO 109 106 106 CSO CSO A . n 
A 1 110 ALA 110 107 107 ALA ALA A . n 
A 1 111 GLY 111 108 108 GLY GLY A . n 
A 1 112 PRO 112 109 109 PRO PRO A . n 
A 1 113 THR 113 110 110 THR THR A . n 
A 1 114 ALA 114 111 111 ALA ALA A . n 
A 1 115 LEU 115 112 112 LEU LEU A . n 
A 1 116 LEU 116 113 113 LEU LEU A . n 
A 1 117 ALA 117 114 114 ALA ALA A . n 
A 1 118 HIS 118 115 115 HIS HIS A . n 
A 1 119 GLU 119 116 116 GLU GLU A . n 
A 1 120 ILE 120 117 117 ILE ILE A . n 
A 1 121 GLY 121 118 118 GLY GLY A . n 
A 1 122 PHE 122 119 119 PHE PHE A . n 
A 1 123 GLY 123 120 120 GLY GLY A . n 
A 1 124 SER 124 121 121 SER SER A . n 
A 1 125 LYS 125 122 122 LYS LYS A . n 
A 1 126 VAL 126 123 123 VAL VAL A . n 
A 1 127 THR 127 124 124 THR THR A . n 
A 1 128 THR 128 125 125 THR THR A . n 
A 1 129 HIS 129 126 126 HIS HIS A . n 
A 1 130 PRO 130 127 127 PRO PRO A . n 
A 1 131 LEU 131 128 128 LEU LEU A . n 
A 1 132 ALA 132 129 129 ALA ALA A . n 
A 1 133 LYS 133 130 130 LYS LYS A . n 
A 1 134 ASP 134 131 131 ASP ASP A . n 
A 1 135 LYS 135 132 132 LYS LYS A . n 
A 1 136 MET 136 133 133 MET MET A . n 
A 1 137 MET 137 134 134 MET MET A . n 
A 1 138 ASN 138 135 135 ASN ASN A . n 
A 1 139 GLY 139 136 136 GLY GLY A . n 
A 1 140 GLY 140 137 137 GLY GLY A . n 
A 1 141 HIS 141 138 138 HIS HIS A . n 
A 1 142 TYR 142 139 139 TYR TYR A . n 
A 1 143 THR 143 140 140 THR THR A . n 
A 1 144 TYR 144 141 141 TYR TYR A . n 
A 1 145 SER 145 142 142 SER SER A . n 
A 1 146 GLU 146 143 143 GLU GLU A . n 
A 1 147 ASN 147 144 144 ASN ASN A . n 
A 1 148 ARG 148 145 145 ARG ARG A . n 
A 1 149 VAL 149 146 146 VAL VAL A . n 
A 1 150 GLU 150 147 147 GLU GLU A . n 
A 1 151 LYS 151 148 148 LYS LYS A . n 
A 1 152 ASP 152 149 149 ASP ASP A . n 
A 1 153 GLY 153 150 150 GLY GLY A . n 
A 1 154 LEU 154 151 151 LEU LEU A . n 
A 1 155 ILE 155 152 152 ILE ILE A . n 
A 1 156 LEU 156 153 153 LEU LEU A . n 
A 1 157 THR 157 154 154 THR THR A . n 
A 1 158 SER 158 155 155 SER SER A . n 
A 1 159 ARG 159 156 156 ARG ARG A . n 
A 1 160 GLY 160 157 157 GLY GLY A . n 
A 1 161 PRO 161 158 158 PRO PRO A . n 
A 1 162 GLY 162 159 159 GLY GLY A . n 
A 1 163 THR 163 160 160 THR THR A . n 
A 1 164 SER 164 161 161 SER SER A . n 
A 1 165 PHE 165 162 162 PHE PHE A . n 
A 1 166 GLU 166 163 163 GLU GLU A . n 
A 1 167 PHE 167 164 164 PHE PHE A . n 
A 1 168 ALA 168 165 165 ALA ALA A . n 
A 1 169 LEU 169 166 166 LEU LEU A . n 
A 1 170 ALA 170 167 167 ALA ALA A . n 
A 1 171 ILE 171 168 168 ILE ILE A . n 
A 1 172 VAL 172 169 169 VAL VAL A . n 
A 1 173 GLU 173 170 170 GLU GLU A . n 
A 1 174 ALA 174 171 171 ALA ALA A . n 
A 1 175 LEU 175 172 172 LEU LEU A . n 
A 1 176 ASN 176 173 173 ASN ASN A . n 
A 1 177 GLY 177 174 174 GLY GLY A . n 
A 1 178 LYS 178 175 175 LYS LYS A . n 
A 1 179 GLU 179 176 176 GLU GLU A . n 
A 1 180 VAL 180 177 177 VAL VAL A . n 
A 1 181 ALA 181 178 178 ALA ALA A . n 
A 1 182 ALA 182 179 179 ALA ALA A . n 
A 1 183 GLN 183 180 180 GLN GLN A . n 
A 1 184 VAL 184 181 181 VAL VAL A . n 
A 1 185 LYS 185 182 182 LYS LYS A . n 
A 1 186 ALA 186 183 183 ALA ALA A . n 
A 1 187 PRO 187 184 184 PRO PRO A . n 
A 1 188 LEU 188 185 185 LEU LEU A . n 
A 1 189 VAL 189 186 186 VAL VAL A . n 
A 1 190 LEU 190 187 187 LEU LEU A . n 
A 1 191 LYS 191 188 188 LYS LYS A . n 
A 1 192 ASP 192 189 189 ASP ASP A . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 HOH 1   201 116 HOH HOH A . 
B 2 HOH 2   202 27  HOH HOH A . 
B 2 HOH 3   203 4   HOH HOH A . 
B 2 HOH 4   204 28  HOH HOH A . 
B 2 HOH 5   205 23  HOH HOH A . 
B 2 HOH 6   206 6   HOH HOH A . 
B 2 HOH 7   207 41  HOH HOH A . 
B 2 HOH 8   208 119 HOH HOH A . 
B 2 HOH 9   209 25  HOH HOH A . 
B 2 HOH 10  210 29  HOH HOH A . 
B 2 HOH 11  211 77  HOH HOH A . 
B 2 HOH 12  212 3   HOH HOH A . 
B 2 HOH 13  213 129 HOH HOH A . 
B 2 HOH 14  214 66  HOH HOH A . 
B 2 HOH 15  215 82  HOH HOH A . 
B 2 HOH 16  216 36  HOH HOH A . 
B 2 HOH 17  217 86  HOH HOH A . 
B 2 HOH 18  218 126 HOH HOH A . 
B 2 HOH 19  219 35  HOH HOH A . 
B 2 HOH 20  220 117 HOH HOH A . 
B 2 HOH 21  221 93  HOH HOH A . 
B 2 HOH 22  222 32  HOH HOH A . 
B 2 HOH 23  223 10  HOH HOH A . 
B 2 HOH 24  224 130 HOH HOH A . 
B 2 HOH 25  225 26  HOH HOH A . 
B 2 HOH 26  226 11  HOH HOH A . 
B 2 HOH 27  227 5   HOH HOH A . 
B 2 HOH 28  228 74  HOH HOH A . 
B 2 HOH 29  229 57  HOH HOH A . 
B 2 HOH 30  230 60  HOH HOH A . 
B 2 HOH 31  231 9   HOH HOH A . 
B 2 HOH 32  232 21  HOH HOH A . 
B 2 HOH 33  233 48  HOH HOH A . 
B 2 HOH 34  234 15  HOH HOH A . 
B 2 HOH 35  235 7   HOH HOH A . 
B 2 HOH 36  236 14  HOH HOH A . 
B 2 HOH 37  237 54  HOH HOH A . 
B 2 HOH 38  238 44  HOH HOH A . 
B 2 HOH 39  239 19  HOH HOH A . 
B 2 HOH 40  240 52  HOH HOH A . 
B 2 HOH 41  241 123 HOH HOH A . 
B 2 HOH 42  242 34  HOH HOH A . 
B 2 HOH 43  243 112 HOH HOH A . 
B 2 HOH 44  244 67  HOH HOH A . 
B 2 HOH 45  245 53  HOH HOH A . 
B 2 HOH 46  246 1   HOH HOH A . 
B 2 HOH 47  247 65  HOH HOH A . 
B 2 HOH 48  248 30  HOH HOH A . 
B 2 HOH 49  249 95  HOH HOH A . 
B 2 HOH 50  250 75  HOH HOH A . 
B 2 HOH 51  251 62  HOH HOH A . 
B 2 HOH 52  252 13  HOH HOH A . 
B 2 HOH 53  253 131 HOH HOH A . 
B 2 HOH 54  254 24  HOH HOH A . 
B 2 HOH 55  255 8   HOH HOH A . 
B 2 HOH 56  256 43  HOH HOH A . 
B 2 HOH 57  257 58  HOH HOH A . 
B 2 HOH 58  258 81  HOH HOH A . 
B 2 HOH 59  259 22  HOH HOH A . 
B 2 HOH 60  260 99  HOH HOH A . 
B 2 HOH 61  261 50  HOH HOH A . 
B 2 HOH 62  262 17  HOH HOH A . 
B 2 HOH 63  263 61  HOH HOH A . 
B 2 HOH 64  264 16  HOH HOH A . 
B 2 HOH 65  265 122 HOH HOH A . 
B 2 HOH 66  266 94  HOH HOH A . 
B 2 HOH 67  267 108 HOH HOH A . 
B 2 HOH 68  268 83  HOH HOH A . 
B 2 HOH 69  269 72  HOH HOH A . 
B 2 HOH 70  270 115 HOH HOH A . 
B 2 HOH 71  271 102 HOH HOH A . 
B 2 HOH 72  272 40  HOH HOH A . 
B 2 HOH 73  273 2   HOH HOH A . 
B 2 HOH 74  274 33  HOH HOH A . 
B 2 HOH 75  275 96  HOH HOH A . 
B 2 HOH 76  276 111 HOH HOH A . 
B 2 HOH 77  277 84  HOH HOH A . 
B 2 HOH 78  278 12  HOH HOH A . 
B 2 HOH 79  279 78  HOH HOH A . 
B 2 HOH 80  280 31  HOH HOH A . 
B 2 HOH 81  281 63  HOH HOH A . 
B 2 HOH 82  282 114 HOH HOH A . 
B 2 HOH 83  283 121 HOH HOH A . 
B 2 HOH 84  284 76  HOH HOH A . 
B 2 HOH 85  285 39  HOH HOH A . 
B 2 HOH 86  286 89  HOH HOH A . 
B 2 HOH 87  287 135 HOH HOH A . 
B 2 HOH 88  288 37  HOH HOH A . 
B 2 HOH 89  289 38  HOH HOH A . 
B 2 HOH 90  290 71  HOH HOH A . 
B 2 HOH 91  291 68  HOH HOH A . 
B 2 HOH 92  292 98  HOH HOH A . 
B 2 HOH 93  293 20  HOH HOH A . 
B 2 HOH 94  294 51  HOH HOH A . 
B 2 HOH 95  295 137 HOH HOH A . 
B 2 HOH 96  296 70  HOH HOH A . 
B 2 HOH 97  297 64  HOH HOH A . 
B 2 HOH 98  298 49  HOH HOH A . 
B 2 HOH 99  299 124 HOH HOH A . 
B 2 HOH 100 300 55  HOH HOH A . 
B 2 HOH 101 301 103 HOH HOH A . 
B 2 HOH 102 302 97  HOH HOH A . 
B 2 HOH 103 303 105 HOH HOH A . 
B 2 HOH 104 304 133 HOH HOH A . 
B 2 HOH 105 305 118 HOH HOH A . 
B 2 HOH 106 306 90  HOH HOH A . 
B 2 HOH 107 307 56  HOH HOH A . 
B 2 HOH 108 308 18  HOH HOH A . 
B 2 HOH 109 309 45  HOH HOH A . 
B 2 HOH 110 310 80  HOH HOH A . 
B 2 HOH 111 311 109 HOH HOH A . 
B 2 HOH 112 312 100 HOH HOH A . 
B 2 HOH 113 313 91  HOH HOH A . 
B 2 HOH 114 314 132 HOH HOH A . 
B 2 HOH 115 315 69  HOH HOH A . 
B 2 HOH 116 316 59  HOH HOH A . 
B 2 HOH 117 317 46  HOH HOH A . 
B 2 HOH 118 318 79  HOH HOH A . 
B 2 HOH 119 319 128 HOH HOH A . 
B 2 HOH 120 320 107 HOH HOH A . 
B 2 HOH 121 321 101 HOH HOH A . 
B 2 HOH 122 322 125 HOH HOH A . 
B 2 HOH 123 323 87  HOH HOH A . 
B 2 HOH 124 324 136 HOH HOH A . 
B 2 HOH 125 325 47  HOH HOH A . 
B 2 HOH 126 326 106 HOH HOH A . 
B 2 HOH 127 327 73  HOH HOH A . 
B 2 HOH 128 328 85  HOH HOH A . 
B 2 HOH 129 329 88  HOH HOH A . 
B 2 HOH 130 330 127 HOH HOH A . 
B 2 HOH 131 331 120 HOH HOH A . 
B 2 HOH 132 332 42  HOH HOH A . 
B 2 HOH 133 333 113 HOH HOH A . 
B 2 HOH 134 334 134 HOH HOH A . 
B 2 HOH 135 335 104 HOH HOH A . 
B 2 HOH 136 336 92  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX       ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? Precognition ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? CrystFEL     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX       ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9CFQ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     76.030 
_cell.length_a_esd                 ? 
_cell.length_b                     76.030 
_cell.length_b_esd                 ? 
_cell.length_c                     76.140 
_cell.length_c_esd                 ? 
_cell.volume                       381165.412 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9CFQ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9CFQ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.21 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          61.66 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES, 200 mM NaCl, 15% (w/v) PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     293 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   Y 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RAYONIX MX340-HS' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-11-10 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   L 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             LAUE 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
loop_
_diffrn_radiation_wavelength.id 
_diffrn_radiation_wavelength.wavelength 
_diffrn_radiation_wavelength.wt 
1 1.240 1.0 
2 1.016 1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 14-ID-B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.240-1.016 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   14-ID-B 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          26.88 
_reflns.entry_id                                       9CFQ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.77 
_reflns.d_resolution_low                               32.96 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25005 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.03 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                246 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          7.74 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.99 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   0.0598 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.77 
_reflns_shell.d_res_low                                     1.80 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           0.43 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2426 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.05 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.62 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               32.75 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9CFQ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.90 
_refine.ls_d_res_low                             32.96 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     20293 
_refine.ls_number_reflns_R_free                  1017 
_refine.ls_number_reflns_R_work                  19276 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.12 
_refine.ls_percent_reflns_R_free                 5.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1502 
_refine.ls_R_factor_R_free                       0.1686 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1492 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.35 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'FOURIER SYNTHESIS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 18.2506 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1848 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        32.96 
_refine_hist.number_atoms_solvent             136 
_refine_hist.number_atoms_total               1520 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1384 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         0 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0056  ? 1469 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.6023  ? 1994 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0486  ? 234  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0056  ? 263  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 14.7700 ? 573  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.90 2.00  . . 147 2716 99.07 . . . . 0.2988 . . . . . . . . . . . 0.3094 
'X-RAY DIFFRACTION' 2.00 2.13  . . 144 2703 99.10 . . . . 0.2244 . . . . . . . . . . . 0.2368 
'X-RAY DIFFRACTION' 2.13 2.29  . . 161 2718 99.28 . . . . 0.1913 . . . . . . . . . . . 0.2458 
'X-RAY DIFFRACTION' 2.29 2.52  . . 134 2720 99.13 . . . . 0.1606 . . . . . . . . . . . 0.1700 
'X-RAY DIFFRACTION' 2.52 2.88  . . 145 2751 99.14 . . . . 0.1502 . . . . . . . . . . . 0.1710 
'X-RAY DIFFRACTION' 2.89 3.63  . . 127 2787 99.08 . . . . 0.1321 . . . . . . . . . . . 0.1676 
'X-RAY DIFFRACTION' 3.63 32.96 . . 159 2881 99.06 . . . . 0.1092 . . . . . . . . . . . 0.1197 
# 
_struct.entry_id                     9CFQ 
_struct.title                        'Human DJ-1, no mixing, pink beam time-resolved serial crystallography, CrystFEL processed' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9CFQ 
_struct_keywords.text            
'Glutathione-independent glyoxalase, mix-and-inject serial crystallography, Laue diffraction, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PARK7_HUMAN 
_struct_ref.pdbx_db_accession          Q99497 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQ
NLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGT
SFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9CFQ 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 4 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 192 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q99497 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  189 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       189 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9CFQ GLY A 1 ? UNP Q99497 ? ? 'expression tag' -2 1 
1 9CFQ SER A 2 ? UNP Q99497 ? ? 'expression tag' -1 2 
1 9CFQ HIS A 3 ? UNP Q99497 ? ? 'expression tag' 0  3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2820  ? 
1 MORE         -17   ? 
1 'SSA (A^2)'  15120 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z         1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 5_555 x-y,-y,-z+2/3 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 50.7600000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 18  ? ALA A 32  ? GLU A 15  ALA A 29  1 ? 15 
HELX_P HELX_P2  AA2 LEU A 61  ? GLU A 67  ? LEU A 58  GLU A 64  1 ? 7  
HELX_P HELX_P3  AA3 GLY A 78  ? GLU A 87  ? GLY A 75  GLU A 84  1 ? 10 
HELX_P HELX_P4  AA4 SER A 88  ? ARG A 101 ? SER A 85  ARG A 98  1 ? 14 
HELX_P HELX_P5  AA5 PRO A 112 ? HIS A 118 ? PRO A 109 HIS A 115 1 ? 7  
HELX_P HELX_P6  AA6 HIS A 129 ? LEU A 131 ? HIS A 126 LEU A 128 5 ? 3  
HELX_P HELX_P7  AA7 ALA A 132 ? MET A 137 ? ALA A 129 MET A 134 1 ? 6  
HELX_P HELX_P8  AA8 GLY A 160 ? GLY A 162 ? GLY A 157 GLY A 159 5 ? 3  
HELX_P HELX_P9  AA9 THR A 163 ? GLY A 177 ? THR A 160 GLY A 174 1 ? 15 
HELX_P HELX_P10 AB1 GLY A 177 ? ALA A 186 ? GLY A 174 ALA A 183 1 ? 10 
HELX_P HELX_P11 AB2 PRO A 187 ? VAL A 189 ? PRO A 184 VAL A 186 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A ILE 108 C ? ? ? 1_555 A CSO 109 N ? ? A ILE 105 A CSO 106 1_555 ? ? ? ? ? ? ? 1.338 ? ? 
covale2 covale both ? A CSO 109 C ? ? ? 1_555 A ALA 110 N ? ? A CSO 106 A ALA 107 1_555 ? ? ? ? ? ? ? 1.328 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CSO 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       109 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     . 
_pdbx_modification_feature.modified_residue_label_asym_id     . 
_pdbx_modification_feature.modified_residue_label_seq_id      . 
_pdbx_modification_feature.modified_residue_label_alt_id      . 
_pdbx_modification_feature.auth_comp_id                       CSO 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        106 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      . 
_pdbx_modification_feature.modified_residue_auth_asym_id      . 
_pdbx_modification_feature.modified_residue_auth_seq_id       . 
_pdbx_modification_feature.modified_residue_PDB_ins_code      . 
_pdbx_modification_feature.modified_residue_symmetry          . 
_pdbx_modification_feature.comp_id_linking_atom               . 
_pdbx_modification_feature.modified_residue_id_linking_atom   . 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        CSO 
_pdbx_modification_feature.type                               Hydroxylation 
_pdbx_modification_feature.category                           'Named protein modification' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           68 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            65 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    69 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     66 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -0.80 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 59  ? SER A 60  ? ALA A 56  SER A 57  
AA1 2 LYS A 35  ? GLY A 40  ? LYS A 32  GLY A 37  
AA1 3 ARG A 8   ? LEU A 13  ? ARG A 5   LEU A 10  
AA1 4 VAL A 72  ? LEU A 75  ? VAL A 69  LEU A 72  
AA1 5 LEU A 104 ? ILE A 108 ? LEU A 101 ILE A 105 
AA1 6 ILE A 155 ? SER A 158 ? ILE A 152 SER A 155 
AA1 7 VAL A 149 ? ASP A 152 ? VAL A 146 ASP A 149 
AA2 1 VAL A 47  ? GLN A 48  ? VAL A 44  GLN A 45  
AA2 2 VAL A 54  ? ILE A 55  ? VAL A 51  ILE A 52  
AA3 1 LYS A 125 ? VAL A 126 ? LYS A 122 VAL A 123 
AA3 2 THR A 143 ? TYR A 144 ? THR A 140 TYR A 141 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ALA A 59  ? O ALA A 56  N GLY A 40  ? N GLY A 37  
AA1 2 3 O ALA A 39  ? O ALA A 36  N VAL A 11  ? N VAL A 8   
AA1 3 4 N LEU A 10  ? N LEU A 7   O VAL A 74  ? O VAL A 71  
AA1 4 5 N LEU A 75  ? N LEU A 72  O ALA A 106 ? O ALA A 103 
AA1 5 6 N ILE A 105 ? N ILE A 102 O LEU A 156 ? O LEU A 153 
AA1 6 7 O THR A 157 ? O THR A 154 N GLU A 150 ? N GLU A 147 
AA2 1 2 N VAL A 47  ? N VAL A 44  O ILE A 55  ? O ILE A 52  
AA3 1 2 N VAL A 126 ? N VAL A 123 O THR A 143 ? O THR A 140 
# 
_pdbx_entry_details.entry_id                   9CFQ 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    CSO 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     106 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             73.22 
_pdbx_validate_torsion.psi             -113.58 
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    A 
_pdbx_struct_mod_residue.label_comp_id    CSO 
_pdbx_struct_mod_residue.label_seq_id     109 
_pdbx_struct_mod_residue.auth_asym_id     A 
_pdbx_struct_mod_residue.auth_comp_id     CSO 
_pdbx_struct_mod_residue.auth_seq_id      106 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   CYS 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY -2 ? A GLY 1 
2 1 Y 1 A SER -1 ? A SER 2 
3 1 Y 1 A HIS 0  ? A HIS 3 
4 1 Y 1 A MET 1  ? A MET 4 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CSO N    N N N 74  
CSO CA   C N R 75  
CSO CB   C N N 76  
CSO SG   S N N 77  
CSO C    C N N 78  
CSO O    O N N 79  
CSO OXT  O N N 80  
CSO OD   O N N 81  
CSO H    H N N 82  
CSO H2   H N N 83  
CSO HA   H N N 84  
CSO HB2  H N N 85  
CSO HB3  H N N 86  
CSO HXT  H N N 87  
CSO HD   H N N 88  
CYS N    N N N 89  
CYS CA   C N R 90  
CYS C    C N N 91  
CYS O    O N N 92  
CYS CB   C N N 93  
CYS SG   S N N 94  
CYS OXT  O N N 95  
CYS H    H N N 96  
CYS H2   H N N 97  
CYS HA   H N N 98  
CYS HB2  H N N 99  
CYS HB3  H N N 100 
CYS HG   H N N 101 
CYS HXT  H N N 102 
GLN N    N N N 103 
GLN CA   C N S 104 
GLN C    C N N 105 
GLN O    O N N 106 
GLN CB   C N N 107 
GLN CG   C N N 108 
GLN CD   C N N 109 
GLN OE1  O N N 110 
GLN NE2  N N N 111 
GLN OXT  O N N 112 
GLN H    H N N 113 
GLN H2   H N N 114 
GLN HA   H N N 115 
GLN HB2  H N N 116 
GLN HB3  H N N 117 
GLN HG2  H N N 118 
GLN HG3  H N N 119 
GLN HE21 H N N 120 
GLN HE22 H N N 121 
GLN HXT  H N N 122 
GLU N    N N N 123 
GLU CA   C N S 124 
GLU C    C N N 125 
GLU O    O N N 126 
GLU CB   C N N 127 
GLU CG   C N N 128 
GLU CD   C N N 129 
GLU OE1  O N N 130 
GLU OE2  O N N 131 
GLU OXT  O N N 132 
GLU H    H N N 133 
GLU H2   H N N 134 
GLU HA   H N N 135 
GLU HB2  H N N 136 
GLU HB3  H N N 137 
GLU HG2  H N N 138 
GLU HG3  H N N 139 
GLU HE2  H N N 140 
GLU HXT  H N N 141 
GLY N    N N N 142 
GLY CA   C N N 143 
GLY C    C N N 144 
GLY O    O N N 145 
GLY OXT  O N N 146 
GLY H    H N N 147 
GLY H2   H N N 148 
GLY HA2  H N N 149 
GLY HA3  H N N 150 
GLY HXT  H N N 151 
HIS N    N N N 152 
HIS CA   C N S 153 
HIS C    C N N 154 
HIS O    O N N 155 
HIS CB   C N N 156 
HIS CG   C Y N 157 
HIS ND1  N Y N 158 
HIS CD2  C Y N 159 
HIS CE1  C Y N 160 
HIS NE2  N Y N 161 
HIS OXT  O N N 162 
HIS H    H N N 163 
HIS H2   H N N 164 
HIS HA   H N N 165 
HIS HB2  H N N 166 
HIS HB3  H N N 167 
HIS HD1  H N N 168 
HIS HD2  H N N 169 
HIS HE1  H N N 170 
HIS HE2  H N N 171 
HIS HXT  H N N 172 
HOH O    O N N 173 
HOH H1   H N N 174 
HOH H2   H N N 175 
ILE N    N N N 176 
ILE CA   C N S 177 
ILE C    C N N 178 
ILE O    O N N 179 
ILE CB   C N S 180 
ILE CG1  C N N 181 
ILE CG2  C N N 182 
ILE CD1  C N N 183 
ILE OXT  O N N 184 
ILE H    H N N 185 
ILE H2   H N N 186 
ILE HA   H N N 187 
ILE HB   H N N 188 
ILE HG12 H N N 189 
ILE HG13 H N N 190 
ILE HG21 H N N 191 
ILE HG22 H N N 192 
ILE HG23 H N N 193 
ILE HD11 H N N 194 
ILE HD12 H N N 195 
ILE HD13 H N N 196 
ILE HXT  H N N 197 
LEU N    N N N 198 
LEU CA   C N S 199 
LEU C    C N N 200 
LEU O    O N N 201 
LEU CB   C N N 202 
LEU CG   C N N 203 
LEU CD1  C N N 204 
LEU CD2  C N N 205 
LEU OXT  O N N 206 
LEU H    H N N 207 
LEU H2   H N N 208 
LEU HA   H N N 209 
LEU HB2  H N N 210 
LEU HB3  H N N 211 
LEU HG   H N N 212 
LEU HD11 H N N 213 
LEU HD12 H N N 214 
LEU HD13 H N N 215 
LEU HD21 H N N 216 
LEU HD22 H N N 217 
LEU HD23 H N N 218 
LEU HXT  H N N 219 
LYS N    N N N 220 
LYS CA   C N S 221 
LYS C    C N N 222 
LYS O    O N N 223 
LYS CB   C N N 224 
LYS CG   C N N 225 
LYS CD   C N N 226 
LYS CE   C N N 227 
LYS NZ   N N N 228 
LYS OXT  O N N 229 
LYS H    H N N 230 
LYS H2   H N N 231 
LYS HA   H N N 232 
LYS HB2  H N N 233 
LYS HB3  H N N 234 
LYS HG2  H N N 235 
LYS HG3  H N N 236 
LYS HD2  H N N 237 
LYS HD3  H N N 238 
LYS HE2  H N N 239 
LYS HE3  H N N 240 
LYS HZ1  H N N 241 
LYS HZ2  H N N 242 
LYS HZ3  H N N 243 
LYS HXT  H N N 244 
MET N    N N N 245 
MET CA   C N S 246 
MET C    C N N 247 
MET O    O N N 248 
MET CB   C N N 249 
MET CG   C N N 250 
MET SD   S N N 251 
MET CE   C N N 252 
MET OXT  O N N 253 
MET H    H N N 254 
MET H2   H N N 255 
MET HA   H N N 256 
MET HB2  H N N 257 
MET HB3  H N N 258 
MET HG2  H N N 259 
MET HG3  H N N 260 
MET HE1  H N N 261 
MET HE2  H N N 262 
MET HE3  H N N 263 
MET HXT  H N N 264 
PHE N    N N N 265 
PHE CA   C N S 266 
PHE C    C N N 267 
PHE O    O N N 268 
PHE CB   C N N 269 
PHE CG   C Y N 270 
PHE CD1  C Y N 271 
PHE CD2  C Y N 272 
PHE CE1  C Y N 273 
PHE CE2  C Y N 274 
PHE CZ   C Y N 275 
PHE OXT  O N N 276 
PHE H    H N N 277 
PHE H2   H N N 278 
PHE HA   H N N 279 
PHE HB2  H N N 280 
PHE HB3  H N N 281 
PHE HD1  H N N 282 
PHE HD2  H N N 283 
PHE HE1  H N N 284 
PHE HE2  H N N 285 
PHE HZ   H N N 286 
PHE HXT  H N N 287 
PRO N    N N N 288 
PRO CA   C N S 289 
PRO C    C N N 290 
PRO O    O N N 291 
PRO CB   C N N 292 
PRO CG   C N N 293 
PRO CD   C N N 294 
PRO OXT  O N N 295 
PRO H    H N N 296 
PRO HA   H N N 297 
PRO HB2  H N N 298 
PRO HB3  H N N 299 
PRO HG2  H N N 300 
PRO HG3  H N N 301 
PRO HD2  H N N 302 
PRO HD3  H N N 303 
PRO HXT  H N N 304 
SER N    N N N 305 
SER CA   C N S 306 
SER C    C N N 307 
SER O    O N N 308 
SER CB   C N N 309 
SER OG   O N N 310 
SER OXT  O N N 311 
SER H    H N N 312 
SER H2   H N N 313 
SER HA   H N N 314 
SER HB2  H N N 315 
SER HB3  H N N 316 
SER HG   H N N 317 
SER HXT  H N N 318 
THR N    N N N 319 
THR CA   C N S 320 
THR C    C N N 321 
THR O    O N N 322 
THR CB   C N R 323 
THR OG1  O N N 324 
THR CG2  C N N 325 
THR OXT  O N N 326 
THR H    H N N 327 
THR H2   H N N 328 
THR HA   H N N 329 
THR HB   H N N 330 
THR HG1  H N N 331 
THR HG21 H N N 332 
THR HG22 H N N 333 
THR HG23 H N N 334 
THR HXT  H N N 335 
TYR N    N N N 336 
TYR CA   C N S 337 
TYR C    C N N 338 
TYR O    O N N 339 
TYR CB   C N N 340 
TYR CG   C Y N 341 
TYR CD1  C Y N 342 
TYR CD2  C Y N 343 
TYR CE1  C Y N 344 
TYR CE2  C Y N 345 
TYR CZ   C Y N 346 
TYR OH   O N N 347 
TYR OXT  O N N 348 
TYR H    H N N 349 
TYR H2   H N N 350 
TYR HA   H N N 351 
TYR HB2  H N N 352 
TYR HB3  H N N 353 
TYR HD1  H N N 354 
TYR HD2  H N N 355 
TYR HE1  H N N 356 
TYR HE2  H N N 357 
TYR HH   H N N 358 
TYR HXT  H N N 359 
VAL N    N N N 360 
VAL CA   C N S 361 
VAL C    C N N 362 
VAL O    O N N 363 
VAL CB   C N N 364 
VAL CG1  C N N 365 
VAL CG2  C N N 366 
VAL OXT  O N N 367 
VAL H    H N N 368 
VAL H2   H N N 369 
VAL HA   H N N 370 
VAL HB   H N N 371 
VAL HG11 H N N 372 
VAL HG12 H N N 373 
VAL HG13 H N N 374 
VAL HG21 H N N 375 
VAL HG22 H N N 376 
VAL HG23 H N N 377 
VAL HXT  H N N 378 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CSO N   CA   sing N N 70  
CSO N   H    sing N N 71  
CSO N   H2   sing N N 72  
CSO CA  CB   sing N N 73  
CSO CA  C    sing N N 74  
CSO CA  HA   sing N N 75  
CSO CB  SG   sing N N 76  
CSO CB  HB2  sing N N 77  
CSO CB  HB3  sing N N 78  
CSO SG  OD   sing N N 79  
CSO C   O    doub N N 80  
CSO C   OXT  sing N N 81  
CSO OXT HXT  sing N N 82  
CSO OD  HD   sing N N 83  
CYS N   CA   sing N N 84  
CYS N   H    sing N N 85  
CYS N   H2   sing N N 86  
CYS CA  C    sing N N 87  
CYS CA  CB   sing N N 88  
CYS CA  HA   sing N N 89  
CYS C   O    doub N N 90  
CYS C   OXT  sing N N 91  
CYS CB  SG   sing N N 92  
CYS CB  HB2  sing N N 93  
CYS CB  HB3  sing N N 94  
CYS SG  HG   sing N N 95  
CYS OXT HXT  sing N N 96  
GLN N   CA   sing N N 97  
GLN N   H    sing N N 98  
GLN N   H2   sing N N 99  
GLN CA  C    sing N N 100 
GLN CA  CB   sing N N 101 
GLN CA  HA   sing N N 102 
GLN C   O    doub N N 103 
GLN C   OXT  sing N N 104 
GLN CB  CG   sing N N 105 
GLN CB  HB2  sing N N 106 
GLN CB  HB3  sing N N 107 
GLN CG  CD   sing N N 108 
GLN CG  HG2  sing N N 109 
GLN CG  HG3  sing N N 110 
GLN CD  OE1  doub N N 111 
GLN CD  NE2  sing N N 112 
GLN NE2 HE21 sing N N 113 
GLN NE2 HE22 sing N N 114 
GLN OXT HXT  sing N N 115 
GLU N   CA   sing N N 116 
GLU N   H    sing N N 117 
GLU N   H2   sing N N 118 
GLU CA  C    sing N N 119 
GLU CA  CB   sing N N 120 
GLU CA  HA   sing N N 121 
GLU C   O    doub N N 122 
GLU C   OXT  sing N N 123 
GLU CB  CG   sing N N 124 
GLU CB  HB2  sing N N 125 
GLU CB  HB3  sing N N 126 
GLU CG  CD   sing N N 127 
GLU CG  HG2  sing N N 128 
GLU CG  HG3  sing N N 129 
GLU CD  OE1  doub N N 130 
GLU CD  OE2  sing N N 131 
GLU OE2 HE2  sing N N 132 
GLU OXT HXT  sing N N 133 
GLY N   CA   sing N N 134 
GLY N   H    sing N N 135 
GLY N   H2   sing N N 136 
GLY CA  C    sing N N 137 
GLY CA  HA2  sing N N 138 
GLY CA  HA3  sing N N 139 
GLY C   O    doub N N 140 
GLY C   OXT  sing N N 141 
GLY OXT HXT  sing N N 142 
HIS N   CA   sing N N 143 
HIS N   H    sing N N 144 
HIS N   H2   sing N N 145 
HIS CA  C    sing N N 146 
HIS CA  CB   sing N N 147 
HIS CA  HA   sing N N 148 
HIS C   O    doub N N 149 
HIS C   OXT  sing N N 150 
HIS CB  CG   sing N N 151 
HIS CB  HB2  sing N N 152 
HIS CB  HB3  sing N N 153 
HIS CG  ND1  sing Y N 154 
HIS CG  CD2  doub Y N 155 
HIS ND1 CE1  doub Y N 156 
HIS ND1 HD1  sing N N 157 
HIS CD2 NE2  sing Y N 158 
HIS CD2 HD2  sing N N 159 
HIS CE1 NE2  sing Y N 160 
HIS CE1 HE1  sing N N 161 
HIS NE2 HE2  sing N N 162 
HIS OXT HXT  sing N N 163 
HOH O   H1   sing N N 164 
HOH O   H2   sing N N 165 
ILE N   CA   sing N N 166 
ILE N   H    sing N N 167 
ILE N   H2   sing N N 168 
ILE CA  C    sing N N 169 
ILE CA  CB   sing N N 170 
ILE CA  HA   sing N N 171 
ILE C   O    doub N N 172 
ILE C   OXT  sing N N 173 
ILE CB  CG1  sing N N 174 
ILE CB  CG2  sing N N 175 
ILE CB  HB   sing N N 176 
ILE CG1 CD1  sing N N 177 
ILE CG1 HG12 sing N N 178 
ILE CG1 HG13 sing N N 179 
ILE CG2 HG21 sing N N 180 
ILE CG2 HG22 sing N N 181 
ILE CG2 HG23 sing N N 182 
ILE CD1 HD11 sing N N 183 
ILE CD1 HD12 sing N N 184 
ILE CD1 HD13 sing N N 185 
ILE OXT HXT  sing N N 186 
LEU N   CA   sing N N 187 
LEU N   H    sing N N 188 
LEU N   H2   sing N N 189 
LEU CA  C    sing N N 190 
LEU CA  CB   sing N N 191 
LEU CA  HA   sing N N 192 
LEU C   O    doub N N 193 
LEU C   OXT  sing N N 194 
LEU CB  CG   sing N N 195 
LEU CB  HB2  sing N N 196 
LEU CB  HB3  sing N N 197 
LEU CG  CD1  sing N N 198 
LEU CG  CD2  sing N N 199 
LEU CG  HG   sing N N 200 
LEU CD1 HD11 sing N N 201 
LEU CD1 HD12 sing N N 202 
LEU CD1 HD13 sing N N 203 
LEU CD2 HD21 sing N N 204 
LEU CD2 HD22 sing N N 205 
LEU CD2 HD23 sing N N 206 
LEU OXT HXT  sing N N 207 
LYS N   CA   sing N N 208 
LYS N   H    sing N N 209 
LYS N   H2   sing N N 210 
LYS CA  C    sing N N 211 
LYS CA  CB   sing N N 212 
LYS CA  HA   sing N N 213 
LYS C   O    doub N N 214 
LYS C   OXT  sing N N 215 
LYS CB  CG   sing N N 216 
LYS CB  HB2  sing N N 217 
LYS CB  HB3  sing N N 218 
LYS CG  CD   sing N N 219 
LYS CG  HG2  sing N N 220 
LYS CG  HG3  sing N N 221 
LYS CD  CE   sing N N 222 
LYS CD  HD2  sing N N 223 
LYS CD  HD3  sing N N 224 
LYS CE  NZ   sing N N 225 
LYS CE  HE2  sing N N 226 
LYS CE  HE3  sing N N 227 
LYS NZ  HZ1  sing N N 228 
LYS NZ  HZ2  sing N N 229 
LYS NZ  HZ3  sing N N 230 
LYS OXT HXT  sing N N 231 
MET N   CA   sing N N 232 
MET N   H    sing N N 233 
MET N   H2   sing N N 234 
MET CA  C    sing N N 235 
MET CA  CB   sing N N 236 
MET CA  HA   sing N N 237 
MET C   O    doub N N 238 
MET C   OXT  sing N N 239 
MET CB  CG   sing N N 240 
MET CB  HB2  sing N N 241 
MET CB  HB3  sing N N 242 
MET CG  SD   sing N N 243 
MET CG  HG2  sing N N 244 
MET CG  HG3  sing N N 245 
MET SD  CE   sing N N 246 
MET CE  HE1  sing N N 247 
MET CE  HE2  sing N N 248 
MET CE  HE3  sing N N 249 
MET OXT HXT  sing N N 250 
PHE N   CA   sing N N 251 
PHE N   H    sing N N 252 
PHE N   H2   sing N N 253 
PHE CA  C    sing N N 254 
PHE CA  CB   sing N N 255 
PHE CA  HA   sing N N 256 
PHE C   O    doub N N 257 
PHE C   OXT  sing N N 258 
PHE CB  CG   sing N N 259 
PHE CB  HB2  sing N N 260 
PHE CB  HB3  sing N N 261 
PHE CG  CD1  doub Y N 262 
PHE CG  CD2  sing Y N 263 
PHE CD1 CE1  sing Y N 264 
PHE CD1 HD1  sing N N 265 
PHE CD2 CE2  doub Y N 266 
PHE CD2 HD2  sing N N 267 
PHE CE1 CZ   doub Y N 268 
PHE CE1 HE1  sing N N 269 
PHE CE2 CZ   sing Y N 270 
PHE CE2 HE2  sing N N 271 
PHE CZ  HZ   sing N N 272 
PHE OXT HXT  sing N N 273 
PRO N   CA   sing N N 274 
PRO N   CD   sing N N 275 
PRO N   H    sing N N 276 
PRO CA  C    sing N N 277 
PRO CA  CB   sing N N 278 
PRO CA  HA   sing N N 279 
PRO C   O    doub N N 280 
PRO C   OXT  sing N N 281 
PRO CB  CG   sing N N 282 
PRO CB  HB2  sing N N 283 
PRO CB  HB3  sing N N 284 
PRO CG  CD   sing N N 285 
PRO CG  HG2  sing N N 286 
PRO CG  HG3  sing N N 287 
PRO CD  HD2  sing N N 288 
PRO CD  HD3  sing N N 289 
PRO OXT HXT  sing N N 290 
SER N   CA   sing N N 291 
SER N   H    sing N N 292 
SER N   H2   sing N N 293 
SER CA  C    sing N N 294 
SER CA  CB   sing N N 295 
SER CA  HA   sing N N 296 
SER C   O    doub N N 297 
SER C   OXT  sing N N 298 
SER CB  OG   sing N N 299 
SER CB  HB2  sing N N 300 
SER CB  HB3  sing N N 301 
SER OG  HG   sing N N 302 
SER OXT HXT  sing N N 303 
THR N   CA   sing N N 304 
THR N   H    sing N N 305 
THR N   H2   sing N N 306 
THR CA  C    sing N N 307 
THR CA  CB   sing N N 308 
THR CA  HA   sing N N 309 
THR C   O    doub N N 310 
THR C   OXT  sing N N 311 
THR CB  OG1  sing N N 312 
THR CB  CG2  sing N N 313 
THR CB  HB   sing N N 314 
THR OG1 HG1  sing N N 315 
THR CG2 HG21 sing N N 316 
THR CG2 HG22 sing N N 317 
THR CG2 HG23 sing N N 318 
THR OXT HXT  sing N N 319 
TYR N   CA   sing N N 320 
TYR N   H    sing N N 321 
TYR N   H2   sing N N 322 
TYR CA  C    sing N N 323 
TYR CA  CB   sing N N 324 
TYR CA  HA   sing N N 325 
TYR C   O    doub N N 326 
TYR C   OXT  sing N N 327 
TYR CB  CG   sing N N 328 
TYR CB  HB2  sing N N 329 
TYR CB  HB3  sing N N 330 
TYR CG  CD1  doub Y N 331 
TYR CG  CD2  sing Y N 332 
TYR CD1 CE1  sing Y N 333 
TYR CD1 HD1  sing N N 334 
TYR CD2 CE2  doub Y N 335 
TYR CD2 HD2  sing N N 336 
TYR CE1 CZ   doub Y N 337 
TYR CE1 HE1  sing N N 338 
TYR CE2 CZ   sing Y N 339 
TYR CE2 HE2  sing N N 340 
TYR CZ  OH   sing N N 341 
TYR OH  HH   sing N N 342 
TYR OXT HXT  sing N N 343 
VAL N   CA   sing N N 344 
VAL N   H    sing N N 345 
VAL N   H2   sing N N 346 
VAL CA  C    sing N N 347 
VAL CA  CB   sing N N 348 
VAL CA  HA   sing N N 349 
VAL C   O    doub N N 350 
VAL C   OXT  sing N N 351 
VAL CB  CG1  sing N N 352 
VAL CB  CG2  sing N N 353 
VAL CB  HB   sing N N 354 
VAL CG1 HG11 sing N N 355 
VAL CG1 HG12 sing N N 356 
VAL CG1 HG13 sing N N 357 
VAL CG2 HG21 sing N N 358 
VAL CG2 HG22 sing N N 359 
VAL CG2 HG23 sing N N 360 
VAL OXT HXT  sing N N 361 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           R35GM153337 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'Unpublished DJ-1 X-ray structure' 
# 
_pdbx_serial_crystallography_data_reduction.diffrn_id             1 
_pdbx_serial_crystallography_data_reduction.frames_total          89887 
_pdbx_serial_crystallography_data_reduction.xfel_pulse_events     ? 
_pdbx_serial_crystallography_data_reduction.frame_hits            ? 
_pdbx_serial_crystallography_data_reduction.crystal_hits          5332 
_pdbx_serial_crystallography_data_reduction.droplet_hits          ? 
_pdbx_serial_crystallography_data_reduction.frames_failed_index   ? 
_pdbx_serial_crystallography_data_reduction.frames_indexed        5073 
_pdbx_serial_crystallography_data_reduction.lattices_indexed      ? 
_pdbx_serial_crystallography_data_reduction.xfel_run_numbers      ? 
_pdbx_serial_crystallography_data_reduction.lattices_merged       ? 
# 
_pdbx_serial_crystallography_sample_delivery.diffrn_id     1 
_pdbx_serial_crystallography_sample_delivery.description   'Concentric flow injector' 
_pdbx_serial_crystallography_sample_delivery.method        injection 
# 
_pdbx_serial_crystallography_sample_delivery_injection.diffrn_id               1 
_pdbx_serial_crystallography_sample_delivery_injection.description             'flow focused diffusive mixer' 
_pdbx_serial_crystallography_sample_delivery_injection.injector_diameter       ? 
_pdbx_serial_crystallography_sample_delivery_injection.injector_temperature    ? 
_pdbx_serial_crystallography_sample_delivery_injection.injector_pressure       ? 
_pdbx_serial_crystallography_sample_delivery_injection.flow_rate               1 
_pdbx_serial_crystallography_sample_delivery_injection.carrier_solvent         ? 
_pdbx_serial_crystallography_sample_delivery_injection.crystal_concentration   ? 
_pdbx_serial_crystallography_sample_delivery_injection.preparation             ? 
_pdbx_serial_crystallography_sample_delivery_injection.power_by                ? 
_pdbx_serial_crystallography_sample_delivery_injection.injector_nozzle         ? 
_pdbx_serial_crystallography_sample_delivery_injection.jet_diameter            ? 
_pdbx_serial_crystallography_sample_delivery_injection.filter_size             ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9CFQ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013153 
_atom_sites.fract_transf_matrix[1][2]   0.007594 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015187 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.013134 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ALA A 1 5   ? 33.61812 9.74906   -1.38574 1.000 75.74278  ? 2   ALA A N    1 
ATOM   2    C CA   . ALA A 1 5   ? 32.83280 8.62164   -0.88586 1.000 105.54736 ? 2   ALA A CA   1 
ATOM   3    C C    . ALA A 1 5   ? 33.27560 8.23270   0.52710  1.000 109.67144 ? 2   ALA A C    1 
ATOM   4    O O    . ALA A 1 5   ? 34.47382 8.10475   0.80917  1.000 73.86365  ? 2   ALA A O    1 
ATOM   5    C CB   . ALA A 1 5   ? 32.95300 7.42719   -1.82760 1.000 82.00516  ? 2   ALA A CB   1 
ATOM   6    H HA   . ALA A 1 5   ? 31.89881 8.88102   -0.84998 1.000 126.67581 ? 2   ALA A HA   1 
ATOM   7    H HB1  . ALA A 1 5   ? 32.42002 6.69545   -1.47918 1.000 98.42517  ? 2   ALA A HB1  1 
ATOM   8    H HB2  . ALA A 1 5   ? 32.62947 7.68334   -2.70544 1.000 98.42517  ? 2   ALA A HB2  1 
ATOM   9    H HB3  . ALA A 1 5   ? 33.88415 7.16111   -1.88291 1.000 98.42517  ? 2   ALA A HB3  1 
ATOM   10   N N    . SER A 1 6   ? 32.30145 8.04335   1.41304  1.000 72.64135  ? 3   SER A N    1 
ATOM   11   C CA   . SER A 1 6   ? 32.57234 7.69718   2.80155  1.000 63.10986  ? 3   SER A CA   1 
ATOM   12   C C    . SER A 1 6   ? 32.63029 6.18009   2.95565  1.000 43.31583  ? 3   SER A C    1 
ATOM   13   O O    . SER A 1 6   ? 31.74465 5.46602   2.47458  1.000 44.22700  ? 3   SER A O    1 
ATOM   14   C CB   . SER A 1 6   ? 31.49577 8.29177   3.71249  1.000 74.16654  ? 3   SER A CB   1 
ATOM   15   O OG   . SER A 1 6   ? 31.78799 8.05809   5.07991  1.000 68.29896  ? 3   SER A OG   1 
ATOM   16   H H    . SER A 1 6   ? 31.46392 8.11106   1.22983  1.000 87.18861  ? 3   SER A H    1 
ATOM   17   H HA   . SER A 1 6   ? 33.43226 8.05751   3.06912  1.000 75.75081  ? 3   SER A HA   1 
ATOM   18   H HB2  . SER A 1 6   ? 31.45027 9.24875   3.56075  1.000 89.01883  ? 3   SER A HB2  1 
ATOM   19   H HB3  . SER A 1 6   ? 30.64315 7.88118   3.49952  1.000 89.01883  ? 3   SER A HB3  1 
ATOM   20   H HG   . SER A 1 6   ? 31.13835 8.29458   5.55701  1.000 81.97774  ? 3   SER A HG   1 
ATOM   21   N N    . LYS A 1 7   ? 33.67261 5.69197   3.62415  1.000 41.00593  ? 4   LYS A N    1 
ATOM   22   C CA   . LYS A 1 7   ? 33.80497 4.26088   3.86345  1.000 36.59268  ? 4   LYS A CA   1 
ATOM   23   C C    . LYS A 1 7   ? 32.78456 3.79419   4.89764  1.000 32.98756  ? 4   LYS A C    1 
ATOM   24   O O    . LYS A 1 7   ? 32.32093 4.56486   5.73957  1.000 30.41117  ? 4   LYS A O    1 
ATOM   25   C CB   . LYS A 1 7   ? 35.21990 3.93559   4.33541  1.000 36.17444  ? 4   LYS A CB   1 
ATOM   26   C CG   . LYS A 1 7   ? 36.32435 4.45454   3.41698  1.000 42.66150  ? 4   LYS A CG   1 
ATOM   27   C CD   . LYS A 1 7   ? 36.58337 3.53559   2.23990  1.000 46.63804  ? 4   LYS A CD   1 
ATOM   28   C CE   . LYS A 1 7   ? 37.75765 4.04637   1.40124  1.000 51.14278  ? 4   LYS A CE   1 
ATOM   29   N NZ   . LYS A 1 7   ? 38.25023 3.03217   0.42234  1.000 63.88126  ? 4   LYS A NZ   1 
ATOM   30   H H    . LYS A 1 7   ? 34.31269 6.16680   3.94732  1.000 49.22610  ? 4   LYS A H    1 
ATOM   31   H HA   . LYS A 1 7   ? 33.64221 3.77471   3.04001  1.000 43.93019  ? 4   LYS A HA   1 
ATOM   32   H HB2  . LYS A 1 7   ? 35.35379 4.33367   5.20978  1.000 43.42831  ? 4   LYS A HB2  1 
ATOM   33   H HB3  . LYS A 1 7   ? 35.31353 2.97177   4.39184  1.000 43.42831  ? 4   LYS A HB3  1 
ATOM   34   H HG2  . LYS A 1 7   ? 36.06571 5.32227   3.06905  1.000 51.21278  ? 4   LYS A HG2  1 
ATOM   35   H HG3  . LYS A 1 7   ? 37.14771 4.53234   3.92386  1.000 51.21278  ? 4   LYS A HG3  1 
ATOM   36   H HD2  . LYS A 1 7   ? 36.79955 2.64716   2.56369  1.000 55.98463  ? 4   LYS A HD2  1 
ATOM   37   H HD3  . LYS A 1 7   ? 35.79465 3.50050   1.67635  1.000 55.98463  ? 4   LYS A HD3  1 
ATOM   38   H HE2  . LYS A 1 7   ? 37.47476 4.83008   0.90458  1.000 61.39032  ? 4   LYS A HE2  1 
ATOM   39   H HE3  . LYS A 1 7   ? 38.49249 4.27515   1.99164  1.000 61.39032  ? 4   LYS A HE3  1 
ATOM   40   H HZ1  . LYS A 1 7   ? 38.90968 3.37611   -0.06647 1.000 76.67649  ? 4   LYS A HZ1  1 
ATOM   41   H HZ2  . LYS A 1 7   ? 38.55394 2.31530   0.85357  1.000 76.67649  ? 4   LYS A HZ2  1 
ATOM   42   H HZ3  . LYS A 1 7   ? 37.58833 2.78483   -0.11878 1.000 76.67649  ? 4   LYS A HZ3  1 
ATOM   43   N N    . ARG A 1 8   ? 32.44006 2.51270   4.83472  1.000 28.58561  ? 5   ARG A N    1 
ATOM   44   C CA   . ARG A 1 8   ? 31.37369 1.95125   5.65425  1.000 29.61048  ? 5   ARG A CA   1 
ATOM   45   C C    . ARG A 1 8   ? 31.86316 0.67584   6.32680  1.000 27.37416  ? 5   ARG A C    1 
ATOM   46   O O    . ARG A 1 8   ? 32.53683 -0.14945  5.70294  1.000 25.71933  ? 5   ARG A O    1 
ATOM   47   C CB   . ARG A 1 8   ? 30.11768 1.66494   4.80572  1.000 36.38951  ? 5   ARG A CB   1 
ATOM   48   C CG   . ARG A 1 8   ? 29.61243 2.89902   4.05158  1.000 46.95824  ? 5   ARG A CG   1 
ATOM   49   C CD   . ARG A 1 8   ? 28.55904 2.55574   3.00445  1.000 54.40392  ? 5   ARG A CD   1 
ATOM   50   N NE   . ARG A 1 8   ? 27.22455 2.46918   3.58182  1.000 74.51289  ? 5   ARG A NE   1 
ATOM   51   C CZ   . ARG A 1 8   ? 26.59589 1.33015   3.82986  1.000 83.19305  ? 5   ARG A CZ   1 
ATOM   52   N NH1  . ARG A 1 8   ? 27.14277 0.16135   3.53471  1.000 94.17561  ? 5   ARG A NH1  1 
ATOM   53   N NH2  . ARG A 1 8   ? 25.38765 1.36302   4.38529  1.000 72.72780  ? 5   ARG A NH2  1 
ATOM   54   H H    . ARG A 1 8   ? 32.81621 1.93924   4.31583  1.000 34.32171  ? 5   ARG A H    1 
ATOM   55   H HA   . ARG A 1 8   ? 31.12982 2.57821   6.35307  1.000 35.55155  ? 5   ARG A HA   1 
ATOM   56   H HB2  . ARG A 1 8   ? 30.32859 0.97995   4.15211  1.000 43.68639  ? 5   ARG A HB2  1 
ATOM   57   H HB3  . ARG A 1 8   ? 29.40626 1.35855   5.38960  1.000 43.68639  ? 5   ARG A HB3  1 
ATOM   58   H HG2  . ARG A 1 8   ? 29.21558 3.51720   4.68504  1.000 56.36887  ? 5   ARG A HG2  1 
ATOM   59   H HG3  . ARG A 1 8   ? 30.35902 3.32161   3.59890  1.000 56.36887  ? 5   ARG A HG3  1 
ATOM   60   H HD2  . ARG A 1 8   ? 28.55007 3.24552   2.32253  1.000 65.30369  ? 5   ARG A HD2  1 
ATOM   61   H HD3  . ARG A 1 8   ? 28.77297 1.69777   2.60569  1.000 65.30369  ? 5   ARG A HD3  1 
ATOM   62   H HE   . ARG A 1 8   ? 26.81971 3.20330   3.77357  1.000 89.43445  ? 5   ARG A HE   1 
ATOM   63   H HH11 . ARG A 1 8   ? 26.71804 -0.56708  3.70380  1.000 113.02971 ? 5   ARG A HH11 1 
ATOM   64   H HH12 . ARG A 1 8   ? 27.92279 0.13044   3.17387  1.000 113.02971 ? 5   ARG A HH12 1 
ATOM   65   H HH21 . ARG A 1 8   ? 25.02380 2.11781   4.57893  1.000 87.29234  ? 5   ARG A HH21 1 
ATOM   66   H HH22 . ARG A 1 8   ? 24.97035 0.62947   4.55073  1.000 87.29234  ? 5   ARG A HH22 1 
ATOM   67   N N    . ALA A 1 9   ? 31.52712 0.52467   7.60401  1.000 24.80914  ? 6   ALA A N    1 
ATOM   68   C CA   . ALA A 1 9   ? 31.93543 -0.62172  8.39949  1.000 23.55353  ? 6   ALA A CA   1 
ATOM   69   C C    . ALA A 1 9   ? 30.71478 -1.26256  9.03503  1.000 23.94293  ? 6   ALA A C    1 
ATOM   70   O O    . ALA A 1 9   ? 29.81681 -0.56816  9.52384  1.000 23.25639  ? 6   ALA A O    1 
ATOM   71   C CB   . ALA A 1 9   ? 32.93204 -0.21142  9.49872  1.000 24.15398  ? 6   ALA A CB   1 
ATOM   72   H H    . ALA A 1 9   ? 31.04956 1.09029   8.04175  1.000 29.78995  ? 6   ALA A H    1 
ATOM   73   H HA   . ALA A 1 9   ? 32.36134 -1.27675  7.82465  1.000 28.28321  ? 6   ALA A HA   1 
ATOM   74   H HB1  . ALA A 1 9   ? 33.19205 -1.00029  9.99970  1.000 29.00376  ? 6   ALA A HB1  1 
ATOM   75   H HB2  . ALA A 1 9   ? 33.71216 0.18917   9.08418  1.000 29.00376  ? 6   ALA A HB2  1 
ATOM   76   H HB3  . ALA A 1 9   ? 32.50525 0.42935   10.08876 1.000 29.00376  ? 6   ALA A HB3  1 
ATOM   77   N N    . LEU A 1 10  ? 30.69234 -2.58975  9.02517  1.000 21.27627  ? 7   LEU A N    1 
ATOM   78   C CA   . LEU A 1 10  ? 29.65252 -3.37563  9.67597  1.000 22.68213  ? 7   LEU A CA   1 
ATOM   79   C C    . LEU A 1 10  ? 30.27300 -4.08264  10.87237 1.000 23.19481  ? 7   LEU A C    1 
ATOM   80   O O    . LEU A 1 10  ? 31.22561 -4.85545  10.71046 1.000 23.55978  ? 7   LEU A O    1 
ATOM   81   C CB   . LEU A 1 10  ? 29.04215 -4.39885  8.71970  1.000 23.96594  ? 7   LEU A CB   1 
ATOM   82   C CG   . LEU A 1 10  ? 28.00627 -5.32955  9.33658  1.000 24.38328  ? 7   LEU A CG   1 
ATOM   83   C CD1  . LEU A 1 10  ? 26.74696 -4.55933  9.72357  1.000 28.13234  ? 7   LEU A CD1  1 
ATOM   84   C CD2  . LEU A 1 10  ? 27.67042 -6.47970  8.39185  1.000 27.56020  ? 7   LEU A CD2  1 
ATOM   85   H H    . LEU A 1 10  ? 31.28798 -3.07231  8.63536  1.000 25.55051  ? 7   LEU A H    1 
ATOM   86   H HA   . LEU A 1 10  ? 28.94436 -2.78615  9.97915  1.000 27.23754  ? 7   LEU A HA   1 
ATOM   87   H HB2  . LEU A 1 10  ? 28.60777 -3.91967  7.99678  1.000 28.77811  ? 7   LEU A HB2  1 
ATOM   88   H HB3  . LEU A 1 10  ? 29.75698 -4.95246  8.36837  1.000 28.77811  ? 7   LEU A HB3  1 
ATOM   89   H HG   . LEU A 1 10  ? 28.38011 -5.71377  10.14498 1.000 29.27892  ? 7   LEU A HG   1 
ATOM   90   H HD11 . LEU A 1 10  ? 26.06682 -5.18918  10.00922 1.000 33.77779  ? 7   LEU A HD11 1 
ATOM   91   H HD12 . LEU A 1 10  ? 26.95931 -3.95055  10.44827 1.000 33.77779  ? 7   LEU A HD12 1 
ATOM   92   H HD13 . LEU A 1 10  ? 26.43294 -4.06010  8.95346  1.000 33.77779  ? 7   LEU A HD13 1 
ATOM   93   H HD21 . LEU A 1 10  ? 26.98440 -7.03211  8.79820  1.000 33.09123  ? 7   LEU A HD21 1 
ATOM   94   H HD22 . LEU A 1 10  ? 27.34770 -6.11526  7.55284  1.000 33.09123  ? 7   LEU A HD22 1 
ATOM   95   H HD23 . LEU A 1 10  ? 28.47064 -7.00587  8.23791  1.000 33.09123  ? 7   LEU A HD23 1 
ATOM   96   N N    . VAL A 1 11  ? 29.73377 -3.82309  12.06281 1.000 22.72485  ? 8   VAL A N    1 
ATOM   97   C CA   . VAL A 1 11  ? 30.14202 -4.50311  13.28923 1.000 20.36702  ? 8   VAL A CA   1 
ATOM   98   C C    . VAL A 1 11  ? 28.98522 -5.38679  13.71276 1.000 22.84612  ? 8   VAL A C    1 
ATOM   99   O O    . VAL A 1 11  ? 27.87878 -4.89438  13.95769 1.000 22.91035  ? 8   VAL A O    1 
ATOM   100  C CB   . VAL A 1 11  ? 30.52291 -3.51125  14.39950 1.000 22.04807  ? 8   VAL A CB   1 
ATOM   101  C CG1  . VAL A 1 11  ? 30.91813 -4.24410  15.65895 1.000 23.29085  ? 8   VAL A CG1  1 
ATOM   102  C CG2  . VAL A 1 11  ? 31.63137 -2.60911  13.91843 1.000 20.42060  ? 8   VAL A CG2  1 
ATOM   103  H H    . VAL A 1 11  ? 29.11297 -3.24110  12.18723 1.000 27.28881  ? 8   VAL A H    1 
ATOM   104  H HA   . VAL A 1 11  ? 30.91704 -5.05926  13.11329 1.000 24.45941  ? 8   VAL A HA   1 
ATOM   105  H HB   . VAL A 1 11  ? 29.75534 -2.95970  14.61751 1.000 26.47667  ? 8   VAL A HB   1 
ATOM   106  H HG11 . VAL A 1 11  ? 31.28851 -3.60847  16.29116 1.000 27.96800  ? 8   VAL A HG11 1 
ATOM   107  H HG12 . VAL A 1 11  ? 30.13198 -4.66759  16.03780 1.000 27.96800  ? 8   VAL A HG12 1 
ATOM   108  H HG13 . VAL A 1 11  ? 31.58189 -4.91611  15.43821 1.000 27.96800  ? 8   VAL A HG13 1 
ATOM   109  H HG21 . VAL A 1 11  ? 31.81546 -1.94396  14.60005 1.000 24.52370  ? 8   VAL A HG21 1 
ATOM   110  H HG22 . VAL A 1 11  ? 32.42443 -3.14305  13.75455 1.000 24.52370  ? 8   VAL A HG22 1 
ATOM   111  H HG23 . VAL A 1 11  ? 31.35061 -2.17352  13.09847 1.000 24.52370  ? 8   VAL A HG23 1 
ATOM   112  N N    . ILE A 1 12  ? 29.23062 -6.68883  13.78970 1.000 20.94293  ? 9   ILE A N    1 
ATOM   113  C CA   . ILE A 1 12  ? 28.19582 -7.65942  14.13281 1.000 22.70080  ? 9   ILE A CA   1 
ATOM   114  C C    . ILE A 1 12  ? 28.26467 -7.93609  15.62860 1.000 22.00942  ? 9   ILE A C    1 
ATOM   115  O O    . ILE A 1 12  ? 29.29323 -8.40203  16.13745 1.000 22.22858  ? 9   ILE A O    1 
ATOM   116  C CB   . ILE A 1 12  ? 28.34996 -8.95721  13.32291 1.000 24.74803  ? 9   ILE A CB   1 
ATOM   117  C CG1  . ILE A 1 12  ? 28.33669 -8.63721  11.82384 1.000 24.80962  ? 9   ILE A CG1  1 
ATOM   118  C CG2  . ILE A 1 12  ? 27.24356 -9.94187  13.67751 1.000 26.00015  ? 9   ILE A CG2  1 
ATOM   119  C CD1  . ILE A 1 12  ? 28.48291 -9.84151  10.92814 1.000 29.46084  ? 9   ILE A CD1  1 
ATOM   120  H H    . ILE A 1 12  ? 30.00166 -7.04126  13.64518 1.000 25.15050  ? 9   ILE A H    1 
ATOM   121  H HA   . ILE A 1 12  ? 27.32695 -7.27533  13.93676 1.000 27.25995  ? 9   ILE A HA   1 
ATOM   122  H HB   . ILE A 1 12  ? 29.20013 -9.36751  13.54595 1.000 29.71662  ? 9   ILE A HB   1 
ATOM   123  H HG12 . ILE A 1 12  ? 27.49327 -8.21046  11.60608 1.000 29.79053  ? 9   ILE A HG12 1 
ATOM   124  H HG13 . ILE A 1 12  ? 29.07265 -8.03601  11.62935 1.000 29.79053  ? 9   ILE A HG13 1 
ATOM   125  H HG21 . ILE A 1 12  ? 27.40444 -10.77825 13.21331 1.000 31.21916  ? 9   ILE A HG21 1 
ATOM   126  H HG22 . ILE A 1 12  ? 27.24755 -10.08955 14.63619 1.000 31.21916  ? 9   ILE A HG22 1 
ATOM   127  H HG23 . ILE A 1 12  ? 26.39042 -9.57034  13.40361 1.000 31.21916  ? 9   ILE A HG23 1 
ATOM   128  H HD11 . ILE A 1 12  ? 28.67730 -9.54244  10.02610 1.000 35.37200  ? 9   ILE A HD11 1 
ATOM   129  H HD12 . ILE A 1 12  ? 29.20936 -10.39359 11.25734 1.000 35.37200  ? 9   ILE A HD12 1 
ATOM   130  H HD13 . ILE A 1 12  ? 27.65394 -10.34510 10.93823 1.000 35.37200  ? 9   ILE A HD13 1 
ATOM   131  N N    . LEU A 1 13  ? 27.16044 -7.67747  16.32798 1.000 22.50281  ? 10  LEU A N    1 
ATOM   132  C CA   . LEU A 1 13  ? 27.11649 -7.71587  17.78450 1.000 21.62828  ? 10  LEU A CA   1 
ATOM   133  C C    . LEU A 1 13  ? 26.17284 -8.81981  18.22944 1.000 24.29426  ? 10  LEU A C    1 
ATOM   134  O O    . LEU A 1 13  ? 24.97111 -8.76942  17.94288 1.000 24.60817  ? 10  LEU A O    1 
ATOM   135  C CB   . LEU A 1 13  ? 26.65842 -6.36931  18.34314 1.000 23.93176  ? 10  LEU A CB   1 
ATOM   136  C CG   . LEU A 1 13  ? 26.48370 -6.27775  19.86711 1.000 24.77368  ? 10  LEU A CG   1 
ATOM   137  C CD1  . LEU A 1 13  ? 27.77891 -6.67773  20.56108 1.000 23.33306  ? 10  LEU A CD1  1 
ATOM   138  C CD2  . LEU A 1 13  ? 26.06635 -4.86959  20.24373 1.000 27.23218  ? 10  LEU A CD2  1 
ATOM   139  H H    . LEU A 1 13  ? 26.40619 -7.47231  15.96933 1.000 27.02235  ? 10  LEU A H    1 
ATOM   140  H HA   . LEU A 1 13  ? 28.00071 -7.91839  18.12807 1.000 25.97292  ? 10  LEU A HA   1 
ATOM   141  H HB2  . LEU A 1 13  ? 27.31542 -5.70143  18.09175 1.000 28.73709  ? 10  LEU A HB2  1 
ATOM   142  H HB3  . LEU A 1 13  ? 25.79980 -6.15626  17.94531 1.000 28.73709  ? 10  LEU A HB3  1 
ATOM   143  H HG   . LEU A 1 13  ? 25.79030 -6.88652  20.16627 1.000 29.74740  ? 10  LEU A HG   1 
ATOM   144  H HD11 . LEU A 1 13  ? 27.69894 -6.49281  21.50993 1.000 28.01865  ? 10  LEU A HD11 1 
ATOM   145  H HD12 . LEU A 1 13  ? 27.93298 -7.62504  20.42053 1.000 28.01865  ? 10  LEU A HD12 1 
ATOM   146  H HD13 . LEU A 1 13  ? 28.51058 -6.16416  20.18451 1.000 28.01865  ? 10  LEU A HD13 1 
ATOM   147  H HD21 . LEU A 1 13  ? 25.94611 -4.82231  21.20508 1.000 32.69760  ? 10  LEU A HD21 1 
ATOM   148  H HD22 . LEU A 1 13  ? 26.75913 -4.24999  19.96615 1.000 32.69760  ? 10  LEU A HD22 1 
ATOM   149  H HD23 . LEU A 1 13  ? 25.23303 -4.65659  19.79527 1.000 32.69760  ? 10  LEU A HD23 1 
ATOM   150  N N    . ALA A 1 14  ? 26.71705 -9.80344  18.93355 1.000 23.89046  ? 11  ALA A N    1 
ATOM   151  C CA   . ALA A 1 14  ? 25.96437 -10.94496 19.42936 1.000 22.69549  ? 11  ALA A CA   1 
ATOM   152  C C    . ALA A 1 14  ? 26.08434 -11.03072 20.94407 1.000 24.21505  ? 11  ALA A C    1 
ATOM   153  O O    . ALA A 1 14  ? 27.05784 -10.55400 21.53803 1.000 20.31544  ? 11  ALA A O    1 
ATOM   154  C CB   . ALA A 1 14  ? 26.46648 -12.25373 18.79754 1.000 24.13090  ? 11  ALA A CB   1 
ATOM   155  H H    . ALA A 1 14  ? 27.55046 -9.83208  19.14383 1.000 28.68753  ? 11  ALA A H    1 
ATOM   156  H HA   . ALA A 1 14  ? 25.02676 -10.83498 19.20644 1.000 27.25357  ? 11  ALA A HA   1 
ATOM   157  H HB1  . ALA A 1 14  ? 25.94890 -12.99400 19.15111 1.000 28.97606  ? 11  ALA A HB1  1 
ATOM   158  H HB2  . ALA A 1 14  ? 26.35590 -12.20260 17.83523 1.000 28.97606  ? 11  ALA A HB2  1 
ATOM   159  H HB3  . ALA A 1 14  ? 27.40403 -12.37099 19.01699 1.000 28.97606  ? 11  ALA A HB3  1 
ATOM   160  N N    . LYS A 1 15  ? 25.08262 -11.64468 21.56685 1.000 23.15905  ? 12  LYS A N    1 
ATOM   161  C CA   . LYS A 1 15  ? 25.13240 -11.86010 23.00450 1.000 28.09944  ? 12  LYS A CA   1 
ATOM   162  C C    . LYS A 1 15  ? 26.43539 -12.55987 23.37368 1.000 23.40086  ? 12  LYS A C    1 
ATOM   163  O O    . LYS A 1 15  ? 26.89210 -13.47201 22.67829 1.000 23.30707  ? 12  LYS A O    1 
ATOM   164  C CB   . LYS A 1 15  ? 23.92821 -12.69426 23.46097 1.000 30.50676  ? 12  LYS A CB   1 
ATOM   165  C CG   . LYS A 1 15  ? 23.84249 -12.86471 24.97057 1.000 39.24964  ? 12  LYS A CG   1 
ATOM   166  C CD   . LYS A 1 15  ? 22.65019 -13.72686 25.36639 1.000 48.74535  ? 12  LYS A CD   1 
ATOM   167  C CE   . LYS A 1 15  ? 22.40475 -13.68098 26.87458 1.000 48.32555  ? 12  LYS A CE   1 
ATOM   168  N NZ   . LYS A 1 15  ? 23.59153 -14.14499 27.66179 1.000 66.34044  ? 12  LYS A NZ   1 
ATOM   169  H H    . LYS A 1 15  ? 24.37263 -11.94165 21.18302 1.000 27.80984  ? 12  LYS A H    1 
ATOM   170  H HA   . LYS A 1 15  ? 25.09163 -11.00893 23.46789 1.000 33.73831  ? 12  LYS A HA   1 
ATOM   171  H HB2  . LYS A 1 15  ? 23.11474 -12.25657 23.16501 1.000 36.62710  ? 12  LYS A HB2  1 
ATOM   172  H HB3  . LYS A 1 15  ? 23.99227 -13.57774 23.06567 1.000 36.62710  ? 12  LYS A HB3  1 
ATOM   173  H HG2  . LYS A 1 15  ? 24.65027 -13.29487 25.29204 1.000 47.11855  ? 12  LYS A HG2  1 
ATOM   174  H HG3  . LYS A 1 15  ? 23.74164 -11.99459 25.38726 1.000 47.11855  ? 12  LYS A HG3  1 
ATOM   175  H HD2  . LYS A 1 15  ? 21.85444 -13.40093 24.91756 1.000 58.51340  ? 12  LYS A HD2  1 
ATOM   176  H HD3  . LYS A 1 15  ? 22.82060 -14.64746 25.11272 1.000 58.51340  ? 12  LYS A HD3  1 
ATOM   177  H HE2  . LYS A 1 15  ? 22.20806 -12.76798 27.13658 1.000 58.00965  ? 12  LYS A HE2  1 
ATOM   178  H HE3  . LYS A 1 15  ? 21.65538 -14.25726 27.09194 1.000 58.00965  ? 12  LYS A HE3  1 
ATOM   179  H HZ1  . LYS A 1 15  ? 23.42049 -14.08659 28.53325 1.000 79.62751  ? 12  LYS A HZ1  1 
ATOM   180  H HZ2  . LYS A 1 15  ? 24.29921 -13.63981 27.47185 1.000 79.62751  ? 12  LYS A HZ2  1 
ATOM   181  H HZ3  . LYS A 1 15  ? 23.77845 -14.99147 27.46022 1.000 79.62751  ? 12  LYS A HZ3  1 
ATOM   182  N N    . GLY A 1 16  ? 27.03360 -12.12598 24.47578 1.000 23.63668  ? 13  GLY A N    1 
ATOM   183  C CA   . GLY A 1 16  ? 28.28751 -12.68461 24.92721 1.000 24.08756  ? 13  GLY A CA   1 
ATOM   184  C C    . GLY A 1 16  ? 29.51520 -12.08865 24.28595 1.000 21.59935  ? 13  GLY A C    1 
ATOM   185  O O    . GLY A 1 16  ? 30.62999 -12.52462 24.60109 1.000 22.79705  ? 13  GLY A O    1 
ATOM   186  H H    . GLY A 1 16  ? 26.72543 -11.50198 24.98101 1.000 28.38300  ? 13  GLY A H    1 
ATOM   187  H HA2  . GLY A 1 16  ? 28.35983 -12.55103 25.88524 1.000 28.92406  ? 13  GLY A HA2  1 
ATOM   188  H HA3  . GLY A 1 16  ? 28.28857 -13.63639 24.74009 1.000 28.92406  ? 13  GLY A HA3  1 
ATOM   189  N N    . ALA A 1 17  ? 29.35027 -11.11848 23.39126 1.000 20.84780  ? 14  ALA A N    1 
ATOM   190  C CA   . ALA A 1 17  ? 30.49613 -10.44280 22.80712 1.000 20.81826  ? 14  ALA A CA   1 
ATOM   191  C C    . ALA A 1 17  ? 31.29563 -9.71421  23.88186 1.000 21.46630  ? 14  ALA A C    1 
ATOM   192  O O    . ALA A 1 17  ? 30.76357 -9.28965  24.90946 1.000 20.61667  ? 14  ALA A O    1 
ATOM   193  C CB   . ALA A 1 17  ? 30.04251 -9.44924  21.74348 1.000 20.74059  ? 14  ALA A CB   1 
ATOM   194  H H    . ALA A 1 17  ? 28.58857 -10.83622 23.10888 1.000 25.03634  ? 14  ALA A H    1 
ATOM   195  H HA   . ALA A 1 17  ? 31.07267 -11.09980 22.38660 1.000 25.00090  ? 14  ALA A HA   1 
ATOM   196  H HB1  . ALA A 1 17  ? 30.82158 -9.00629  21.37233 1.000 24.90769  ? 14  ALA A HB1  1 
ATOM   197  H HB2  . ALA A 1 17  ? 29.57018 -9.92835  21.04472 1.000 24.90769  ? 14  ALA A HB2  1 
ATOM   198  H HB3  . ALA A 1 17  ? 29.45387 -8.79564  22.15240 1.000 24.90769  ? 14  ALA A HB3  1 
ATOM   199  N N    . GLU A 1 18  ? 32.59118 -9.56302  23.63462 1.000 18.19794  ? 15  GLU A N    1 
ATOM   200  C CA   . GLU A 1 18  ? 33.44288 -8.77586  24.51934 1.000 17.50026  ? 15  GLU A CA   1 
ATOM   201  C C    . GLU A 1 18  ? 33.18052 -7.30396  24.24462 1.000 19.66134  ? 15  GLU A C    1 
ATOM   202  O O    . GLU A 1 18  ? 33.42633 -6.82637  23.13029 1.000 15.96704  ? 15  GLU A O    1 
ATOM   203  C CB   . GLU A 1 18  ? 34.91252 -9.12565  24.31047 1.000 20.58183  ? 15  GLU A CB   1 
ATOM   204  C CG   . GLU A 1 18  ? 35.68175 -9.28218  25.61185 1.000 20.17436  ? 15  GLU A CG   1 
ATOM   205  C CD   . GLU A 1 18  ? 35.66340 -8.00801  26.45900 1.000 20.24778  ? 15  GLU A CD   1 
ATOM   206  O OE1  . GLU A 1 18  ? 35.63285 -6.90408  25.87503 1.000 15.95085  ? 15  GLU A OE1  1 
ATOM   207  O OE2  . GLU A 1 18  ? 35.68944 -8.11918  27.70099 1.000 19.91431  ? 15  GLU A OE2  1 
ATOM   208  H H    . GLU A 1 18  ? 33.00169 -9.90593  22.96120 1.000 21.85650  ? 15  GLU A H    1 
ATOM   209  H HA   . GLU A 1 18  ? 33.23291 -8.96916  25.44640 1.000 21.01929  ? 15  GLU A HA   1 
ATOM   210  H HB2  . GLU A 1 18  ? 34.96987 -9.96467  23.82709 1.000 24.71717  ? 15  GLU A HB2  1 
ATOM   211  H HB3  . GLU A 1 18  ? 35.33385 -8.41804  23.79797 1.000 24.71717  ? 15  GLU A HB3  1 
ATOM   212  H HG2  . GLU A 1 18  ? 35.28180 -9.99598  26.13283 1.000 24.22821  ? 15  GLU A HG2  1 
ATOM   213  H HG3  . GLU A 1 18  ? 36.60604 -9.49643  25.41017 1.000 24.22821  ? 15  GLU A HG3  1 
ATOM   214  N N    . GLU A 1 19  ? 32.66678 -6.58796  25.25419 1.000 17.17665  ? 16  GLU A N    1 
ATOM   215  C CA   . GLU A 1 19  ? 32.18613 -5.22888  25.01227 1.000 19.94377  ? 16  GLU A CA   1 
ATOM   216  C C    . GLU A 1 19  ? 33.32530 -4.25371  24.74843 1.000 19.07631  ? 16  GLU A C    1 
ATOM   217  O O    . GLU A 1 19  ? 33.14184 -3.28722  24.00144 1.000 17.53655  ? 16  GLU A O    1 
ATOM   218  C CB   . GLU A 1 19  ? 31.33400 -4.74123  26.18210 1.000 19.67204  ? 16  GLU A CB   1 
ATOM   219  C CG   . GLU A 1 19  ? 31.86973 -5.06094  27.56386 1.000 19.22775  ? 16  GLU A CG   1 
ATOM   220  C CD   . GLU A 1 19  ? 31.33019 -6.36793  28.10615 1.000 20.77802  ? 16  GLU A CD   1 
ATOM   221  O OE1  . GLU A 1 19  ? 31.76241 -7.43067  27.61378 1.000 18.57973  ? 16  GLU A OE1  1 
ATOM   222  O OE2  . GLU A 1 19  ? 30.46262 -6.33657  29.00792 1.000 20.03197  ? 16  GLU A OE2  1 
ATOM   223  H H    . GLU A 1 19  ? 32.58865 -6.86137  26.06582 1.000 20.63097  ? 16  GLU A H    1 
ATOM   224  H HA   . GLU A 1 19  ? 31.62294 -5.24870  24.22277 1.000 23.95151  ? 16  GLU A HA   1 
ATOM   225  H HB2  . GLU A 1 19  ? 31.25556 -3.77640  26.11996 1.000 23.62543  ? 16  GLU A HB2  1 
ATOM   226  H HB3  . GLU A 1 19  ? 30.45746 -5.15058  26.11144 1.000 23.62543  ? 16  GLU A HB3  1 
ATOM   227  H HG2  . GLU A 1 19  ? 32.83642 -5.12878  27.52132 1.000 23.09228  ? 16  GLU A HG2  1 
ATOM   228  H HG3  . GLU A 1 19  ? 31.61343 -4.35268  28.17507 1.000 23.09228  ? 16  GLU A HG3  1 
ATOM   229  N N    . MET A 1 20  ? 34.49750 -4.48111  25.34550 1.000 18.48660  ? 17  MET A N    1 
ATOM   230  C CA   . MET A 1 20  ? 35.63784 -3.62403  25.05518 1.000 19.29340  ? 17  MET A CA   1 
ATOM   231  C C    . MET A 1 20  ? 36.07091 -3.78849  23.60328 1.000 19.09616  ? 17  MET A C    1 
ATOM   232  O O    . MET A 1 20  ? 36.38605 -2.80143  22.92715 1.000 16.84718  ? 17  MET A O    1 
ATOM   233  C CB   . MET A 1 20  ? 36.79725 -3.93804  26.00249 1.000 17.39249  ? 17  MET A CB   1 
ATOM   234  C CG   . MET A 1 20  ? 36.51971 -3.68663  27.44576 1.000 19.11901  ? 17  MET A CG   1 
ATOM   235  S SD   . MET A 1 20  ? 38.00164 -3.86373  28.46541 1.000 22.21039  ? 17  MET A SD   1 
ATOM   236  C CE   . MET A 1 20  ? 38.19669 -5.62883  28.56259 1.000 21.42852  ? 17  MET A CE   1 
ATOM   237  H H    . MET A 1 20  ? 34.65199 -5.11173  25.90946 1.000 22.20290  ? 17  MET A H    1 
ATOM   238  H HA   . MET A 1 20  ? 35.38301 -2.70121  25.21127 1.000 23.17107  ? 17  MET A HA   1 
ATOM   239  H HB2  . MET A 1 20  ? 37.02377 -4.87661  25.90940 1.000 20.88997  ? 17  MET A HB2  1 
ATOM   240  H HB3  . MET A 1 20  ? 37.55554 -3.38734  25.75223 1.000 20.88997  ? 17  MET A HB3  1 
ATOM   241  H HG2  . MET A 1 20  ? 36.18500 -2.78252  27.55288 1.000 22.96179  ? 17  MET A HG2  1 
ATOM   242  H HG3  . MET A 1 20  ? 35.85910 -4.32421  27.75876 1.000 22.96179  ? 17  MET A HG3  1 
ATOM   243  H HE1  . MET A 1 20  ? 37.83588 -5.94039  29.40736 1.000 25.73321  ? 17  MET A HE1  1 
ATOM   244  H HE2  . MET A 1 20  ? 37.71770 -6.04049  27.82637 1.000 25.73321  ? 17  MET A HE2  1 
ATOM   245  H HE3  . MET A 1 20  ? 39.14039 -5.84587  28.50579 1.000 25.73321  ? 17  MET A HE3  1 
ATOM   246  N N    . GLU A 1 21  ? 36.08788 -5.03128  23.10718 1.000 18.88104  ? 18  GLU A N    1 
ATOM   247  C CA   . GLU A 1 21  ? 36.46081 -5.31598  21.72503 1.000 18.22633  ? 18  GLU A CA   1 
ATOM   248  C C    . GLU A 1 21  ? 35.42072 -4.82521  20.73070 1.000 20.08379  ? 18  GLU A C    1 
ATOM   249  O O    . GLU A 1 21  ? 35.70644 -4.74284  19.53207 1.000 19.85865  ? 18  GLU A O    1 
ATOM   250  C CB   . GLU A 1 21  ? 36.67951 -6.81708  21.55248 1.000 19.94993  ? 18  GLU A CB   1 
ATOM   251  C CG   . GLU A 1 21  ? 37.79021 -7.36427  22.43763 1.000 20.10209  ? 18  GLU A CG   1 
ATOM   252  C CD   . GLU A 1 21  ? 37.84351 -8.89160  22.43935 1.000 21.09965  ? 18  GLU A CD   1 
ATOM   253  O OE1  . GLU A 1 21  ? 37.15890 -9.50625  21.60008 1.000 19.26079  ? 18  GLU A OE1  1 
ATOM   254  O OE2  . GLU A 1 21  ? 38.56128 -9.46753  23.29444 1.000 19.42055  ? 18  GLU A OE2  1 
ATOM   255  H H    . GLU A 1 21  ? 35.88427 -5.73373  23.55963 1.000 22.67623  ? 18  GLU A H    1 
ATOM   256  H HA   . GLU A 1 21  ? 37.29661 -4.86746  21.52217 1.000 21.89058  ? 18  GLU A HA   1 
ATOM   257  H HB2  . GLU A 1 21  ? 35.85937 -7.28243  21.77990 1.000 23.95890  ? 18  GLU A HB2  1 
ATOM   258  H HB3  . GLU A 1 21  ? 36.91743 -6.99601  20.62929 1.000 23.95890  ? 18  GLU A HB3  1 
ATOM   259  H HG2  . GLU A 1 21  ? 38.64344 -7.03437  22.11505 1.000 24.14149  ? 18  GLU A HG2  1 
ATOM   260  H HG3  . GLU A 1 21  ? 37.64318 -7.06788  23.34946 1.000 24.14149  ? 18  GLU A HG3  1 
ATOM   261  N N    . THR A 1 22  ? 34.22743 -4.49558  21.19870 1.000 19.48322  ? 19  THR A N    1 
ATOM   262  C CA   . THR A 1 22  ? 33.18958 -3.95152  20.33786 1.000 20.59160  ? 19  THR A CA   1 
ATOM   263  C C    . THR A 1 22  ? 33.25769 -2.42906  20.30152 1.000 20.56392  ? 19  THR A C    1 
ATOM   264  O O    . THR A 1 22  ? 33.25779 -1.83412  19.22139 1.000 19.47191  ? 19  THR A O    1 
ATOM   265  C CB   . THR A 1 22  ? 31.81483 -4.41934  20.83057 1.000 21.78984  ? 19  THR A CB   1 
ATOM   266  O OG1  . THR A 1 22  ? 31.76436 -5.84800  20.77429 1.000 21.95209  ? 19  THR A OG1  1 
ATOM   267  C CG2  . THR A 1 22  ? 30.69104 -3.83368  19.98606 1.000 24.80479  ? 19  THR A CG2  1 
ATOM   268  H H    . THR A 1 22  ? 33.99055 -4.57826  22.02129 1.000 23.39885  ? 19  THR A H    1 
ATOM   269  H HA   . THR A 1 22  ? 33.30564 -4.28239  19.43346 1.000 24.72890  ? 19  THR A HA   1 
ATOM   270  H HB   . THR A 1 22  ? 31.67852 -4.11692  21.74209 1.000 26.16679  ? 19  THR A HB   1 
ATOM   271  H HG1  . THR A 1 22  ? 32.35949 -6.17617  21.26799 1.000 26.36149  ? 19  THR A HG1  1 
ATOM   272  H HG21 . THR A 1 22  ? 29.84968 -4.26062  20.21133 1.000 29.78473  ? 19  THR A HG21 1 
ATOM   273  H HG22 . THR A 1 22  ? 30.61447 -2.88080  20.15052 1.000 29.78473  ? 19  THR A HG22 1 
ATOM   274  H HG23 . THR A 1 22  ? 30.87450 -3.97687  19.04439 1.000 29.78473  ? 19  THR A HG23 1 
ATOM   275  N N    . VAL A 1 23  ? 33.35724 -1.79420  21.47455 1.000 19.72083  ? 20  VAL A N    1 
ATOM   276  C CA   . VAL A 1 23  ? 33.23387 -0.34202  21.57039 1.000 20.98178  ? 20  VAL A CA   1 
ATOM   277  C C    . VAL A 1 23  ? 34.49009 0.35065   21.06598 1.000 18.50900  ? 20  VAL A C    1 
ATOM   278  O O    . VAL A 1 23  ? 34.42010 1.40463   20.42686 1.000 19.38886  ? 20  VAL A O    1 
ATOM   279  C CB   . VAL A 1 23  ? 32.91718 0.06161   23.02198 1.000 22.44572  ? 20  VAL A CB   1 
ATOM   280  C CG1  . VAL A 1 23  ? 32.98510 1.56312   23.18223 1.000 23.05653  ? 20  VAL A CG1  1 
ATOM   281  C CG2  . VAL A 1 23  ? 31.54518 -0.47464  23.42701 1.000 24.73139  ? 20  VAL A CG2  1 
ATOM   282  H H    . VAL A 1 23  ? 33.49614 -2.18359  22.22866 1.000 23.68398  ? 20  VAL A H    1 
ATOM   283  H HA   . VAL A 1 23  ? 32.49720 -0.06203  21.00486 1.000 25.19711  ? 20  VAL A HA   1 
ATOM   284  H HB   . VAL A 1 23  ? 33.57965 -0.32640  23.61484 1.000 26.95384  ? 20  VAL A HB   1 
ATOM   285  H HG11 . VAL A 1 23  ? 33.91437 1.83103   23.25696 1.000 27.68682  ? 20  VAL A HG11 1 
ATOM   286  H HG12 . VAL A 1 23  ? 32.58145 1.98213   22.40609 1.000 27.68682  ? 20  VAL A HG12 1 
ATOM   287  H HG13 . VAL A 1 23  ? 32.50206 1.81731   23.98408 1.000 27.68682  ? 20  VAL A HG13 1 
ATOM   288  H HG21 . VAL A 1 23  ? 31.30313 -0.10337  24.28984 1.000 29.69665  ? 20  VAL A HG21 1 
ATOM   289  H HG22 . VAL A 1 23  ? 30.89326 -0.21107  22.75885 1.000 29.69665  ? 20  VAL A HG22 1 
ATOM   290  H HG23 . VAL A 1 23  ? 31.58832 -1.44203  23.48352 1.000 29.69665  ? 20  VAL A HG23 1 
ATOM   291  N N    . ILE A 1 24  ? 35.66281 -0.20087  21.34199 1.000 18.23290  ? 21  ILE A N    1 
ATOM   292  C CA   . ILE A 1 24  ? 36.89009 0.46474   20.91095 1.000 18.87439  ? 21  ILE A CA   1 
ATOM   293  C C    . ILE A 1 24  ? 36.94740 0.60781   19.39208 1.000 18.88015  ? 21  ILE A C    1 
ATOM   294  O O    . ILE A 1 24  ? 37.19049 1.72312   18.90607 1.000 18.29158  ? 21  ILE A O    1 
ATOM   295  C CB   . ILE A 1 24  ? 38.11847 -0.26005  21.49148 1.000 20.38050  ? 21  ILE A CB   1 
ATOM   296  C CG1  . ILE A 1 24  ? 38.16687 -0.03913  23.00496 1.000 23.19272  ? 21  ILE A CG1  1 
ATOM   297  C CG2  . ILE A 1 24  ? 39.39263 0.26877   20.82539 1.000 19.75096  ? 21  ILE A CG2  1 
ATOM   298  C CD1  . ILE A 1 24  ? 39.18532 -0.90293  23.71982 1.000 22.96142  ? 21  ILE A CD1  1 
ATOM   299  H H    . ILE A 1 24  ? 35.77699 -0.94028  21.76606 1.000 21.89846  ? 21  ILE A H    1 
ATOM   300  H HA   . ILE A 1 24  ? 36.88417 1.35862   21.28758 1.000 22.66825  ? 21  ILE A HA   1 
ATOM   301  H HB   . ILE A 1 24  ? 38.05045 -1.21150  21.31536 1.000 24.47559  ? 21  ILE A HB   1 
ATOM   302  H HG12 . ILE A 1 24  ? 38.39346 0.88821   23.17699 1.000 27.85024  ? 21  ILE A HG12 1 
ATOM   303  H HG13 . ILE A 1 24  ? 37.29439 -0.24201  23.37712 1.000 27.85024  ? 21  ILE A HG13 1 
ATOM   304  H HG21 . ILE A 1 24  ? 40.16122 -0.01257  21.34598 1.000 23.72014  ? 21  ILE A HG21 1 
ATOM   305  H HG22 . ILE A 1 24  ? 39.45201 -0.09144  19.92671 1.000 23.72014  ? 21  ILE A HG22 1 
ATOM   306  H HG23 . ILE A 1 24  ? 39.35263 1.23735   20.79156 1.000 23.72014  ? 21  ILE A HG23 1 
ATOM   307  H HD11 . ILE A 1 24  ? 38.96174 -0.93977  24.66298 1.000 27.57268  ? 21  ILE A HD11 1 
ATOM   308  H HD12 . ILE A 1 24  ? 39.16487 -1.79521  23.33993 1.000 27.57268  ? 21  ILE A HD12 1 
ATOM   309  H HD13 . ILE A 1 24  ? 40.06634 -0.51408  23.60366 1.000 27.57268  ? 21  ILE A HD13 1 
ATOM   310  N N    . PRO A 1 25  ? 36.75147 -0.44408  18.60049 1.000 18.07221  ? 22  PRO A N    1 
ATOM   311  C CA   . PRO A 1 25  ? 36.78821 -0.24091  17.14018 1.000 19.40966  ? 22  PRO A CA   1 
ATOM   312  C C    . PRO A 1 25  ? 35.68855 0.68180   16.64447 1.000 17.73578  ? 22  PRO A C    1 
ATOM   313  O O    . PRO A 1 25  ? 35.92956 1.52130   15.76951 1.000 20.64075  ? 22  PRO A O    1 
ATOM   314  C CB   . PRO A 1 25  ? 36.65130 -1.66530  16.58152 1.000 21.95445  ? 22  PRO A CB   1 
ATOM   315  C CG   . PRO A 1 25  ? 37.10556 -2.56438  17.70894 1.000 21.77792  ? 22  PRO A CG   1 
ATOM   316  C CD   . PRO A 1 25  ? 36.64743 -1.86480  18.96747 1.000 19.93321  ? 22  PRO A CD   1 
ATOM   317  H HA   . PRO A 1 25  ? 37.65019 0.11630   16.87503 1.000 23.31057  ? 22  PRO A HA   1 
ATOM   318  H HB2  . PRO A 1 25  ? 35.72692 -1.84162  16.34630 1.000 26.36433  ? 22  PRO A HB2  1 
ATOM   319  H HB3  . PRO A 1 25  ? 37.21813 -1.77129  15.80154 1.000 26.36433  ? 22  PRO A HB3  1 
ATOM   320  H HG2  . PRO A 1 25  ? 36.68995 -3.43684  17.62534 1.000 26.15249  ? 22  PRO A HG2  1 
ATOM   321  H HG3  . PRO A 1 25  ? 38.07128 -2.65404  17.69303 1.000 26.15249  ? 22  PRO A HG3  1 
ATOM   322  H HD2  . PRO A 1 25  ? 35.73215 -2.10210  19.18392 1.000 23.93883  ? 22  PRO A HD2  1 
ATOM   323  H HD3  . PRO A 1 25  ? 37.23004 -2.07486  19.71403 1.000 23.93883  ? 22  PRO A HD3  1 
ATOM   324  N N    . VAL A 1 26  ? 34.47770 0.54727   17.17840 1.000 18.44467  ? 23  VAL A N    1 
ATOM   325  C CA   . VAL A 1 26  ? 33.38378 1.42466   16.76888 1.000 18.06671  ? 23  VAL A CA   1 
ATOM   326  C C    . VAL A 1 26  ? 33.75223 2.88315   17.00438 1.000 17.85707  ? 23  VAL A C    1 
ATOM   327  O O    . VAL A 1 26  ? 33.60455 3.73455   16.11915 1.000 18.33431  ? 23  VAL A O    1 
ATOM   328  C CB   . VAL A 1 26  ? 32.09647 1.04917   17.51757 1.000 17.15387  ? 23  VAL A CB   1 
ATOM   329  C CG1  . VAL A 1 26  ? 31.05003 2.15238   17.35443 1.000 19.02333  ? 23  VAL A CG1  1 
ATOM   330  C CG2  . VAL A 1 26  ? 31.55749 -0.30437  17.00223 1.000 19.91031  ? 23  VAL A CG2  1 
ATOM   331  H H    . VAL A 1 26  ? 34.26446 -0.03668  17.77265 1.000 22.15259  ? 23  VAL A H    1 
ATOM   332  H HA   . VAL A 1 26  ? 33.23285 1.30452   15.81826 1.000 21.69903  ? 23  VAL A HA   1 
ATOM   333  H HB   . VAL A 1 26  ? 32.28867 0.95599   18.46376 1.000 20.60363  ? 23  VAL A HB   1 
ATOM   334  H HG11 . VAL A 1 26  ? 30.17353 1.78841   17.55486 1.000 22.84698  ? 23  VAL A HG11 1 
ATOM   335  H HG12 . VAL A 1 26  ? 31.25573 2.87585   17.96695 1.000 22.84698  ? 23  VAL A HG12 1 
ATOM   336  H HG13 . VAL A 1 26  ? 31.07254 2.47634   16.44040 1.000 22.84698  ? 23  VAL A HG13 1 
ATOM   337  H HG21 . VAL A 1 26  ? 30.75642 -0.53480  17.49830 1.000 23.91135  ? 23  VAL A HG21 1 
ATOM   338  H HG22 . VAL A 1 26  ? 31.34998 -0.22287  16.05820 1.000 23.91135  ? 23  VAL A HG22 1 
ATOM   339  H HG23 . VAL A 1 26  ? 32.23564 -0.98523  17.13426 1.000 23.91135  ? 23  VAL A HG23 1 
ATOM   340  N N    . ASP A 1 27  ? 34.22836 3.18661   18.21080 1.000 19.18868  ? 24  ASP A N    1 
ATOM   341  C CA   . ASP A 1 27  ? 34.59656 4.54994   18.57147 1.000 17.58653  ? 24  ASP A CA   1 
ATOM   342  C C    . ASP A 1 27  ? 35.71177 5.06255   17.66919 1.000 19.08386  ? 24  ASP A C    1 
ATOM   343  O O    . ASP A 1 27  ? 35.60096 6.13326   17.06676 1.000 16.73377  ? 24  ASP A O    1 
ATOM   344  C CB   . ASP A 1 27  ? 35.00272 4.55956   20.05125 1.000 18.78371  ? 24  ASP A CB   1 
ATOM   345  C CG   . ASP A 1 27  ? 35.21306 5.93655   20.60767 1.000 20.56235  ? 24  ASP A CG   1 
ATOM   346  O OD1  . ASP A 1 27  ? 35.82207 6.78772   19.93284 1.000 18.24140  ? 24  ASP A OD1  1 
ATOM   347  O OD2  . ASP A 1 27  ? 34.79696 6.13991   21.75541 1.000 20.96674  ? 24  ASP A OD2  1 
ATOM   348  H H    . ASP A 1 27  ? 34.34842 2.61615   18.84307 1.000 23.04539  ? 24  ASP A H    1 
ATOM   349  H HA   . ASP A 1 27  ? 33.84462 5.15205   18.45762 1.000 21.12282  ? 24  ASP A HA   1 
ATOM   350  H HB2  . ASP A 1 27  ? 34.30267 4.13391   20.57053 1.000 22.55944  ? 24  ASP A HB2  1 
ATOM   351  H HB3  . ASP A 1 27  ? 35.83400 4.06966   20.15064 1.000 22.55944  ? 24  ASP A HB3  1 
ATOM   352  N N    . VAL A 1 28  ? 36.78902 4.29590   17.54835 1.000 17.47474  ? 25  VAL A N    1 
ATOM   353  C CA   . VAL A 1 28  ? 37.94196 4.75654   16.78774 1.000 17.36493  ? 25  VAL A CA   1 
ATOM   354  C C    . VAL A 1 28  ? 37.58495 4.92676   15.32000 1.000 19.16716  ? 25  VAL A C    1 
ATOM   355  O O    . VAL A 1 28  ? 38.01691 5.88449   14.66942 1.000 18.95485  ? 25  VAL A O    1 
ATOM   356  C CB   . VAL A 1 28  ? 39.11886 3.78215   16.97693 1.000 19.34695  ? 25  VAL A CB   1 
ATOM   357  C CG1  . VAL A 1 28  ? 40.24559 4.09229   15.97565 1.000 21.68592  ? 25  VAL A CG1  1 
ATOM   358  C CG2  . VAL A 1 28  ? 39.62634 3.84273   18.39742 1.000 20.59646  ? 25  VAL A CG2  1 
ATOM   359  H H    . VAL A 1 28  ? 36.87717 3.51306   17.89328 1.000 20.98867  ? 25  VAL A H    1 
ATOM   360  H HA   . VAL A 1 28  ? 38.20862 5.62547   17.12650 1.000 20.85690  ? 25  VAL A HA   1 
ATOM   361  H HB   . VAL A 1 28  ? 38.81166 2.87818   16.80559 1.000 23.23532  ? 25  VAL A HB   1 
ATOM   362  H HG11 . VAL A 1 28  ? 41.06938 3.69009   16.29270 1.000 26.04209  ? 25  VAL A HG11 1 
ATOM   363  H HG12 . VAL A 1 28  ? 40.00923 3.72363   15.11013 1.000 26.04209  ? 25  VAL A HG12 1 
ATOM   364  H HG13 . VAL A 1 28  ? 40.35181 5.05405   15.90770 1.000 26.04209  ? 25  VAL A HG13 1 
ATOM   365  H HG21 . VAL A 1 28  ? 40.36990 3.22730   18.49365 1.000 24.73473  ? 25  VAL A HG21 1 
ATOM   366  H HG22 . VAL A 1 28  ? 39.91865 4.74736   18.59003 1.000 24.73473  ? 25  VAL A HG22 1 
ATOM   367  H HG23 . VAL A 1 28  ? 38.90895 3.59156   19.00005 1.000 24.73473  ? 25  VAL A HG23 1 
ATOM   368  N N    . MET A 1 29  ? 36.81375 3.99759   14.76376 1.000 17.64559  ? 26  MET A N    1 
ATOM   369  C CA   . MET A 1 29  ? 36.44359 4.13211   13.35945 1.000 19.27064  ? 26  MET A CA   1 
ATOM   370  C C    . MET A 1 29  ? 35.59644 5.37793   13.12851 1.000 18.22870  ? 26  MET A C    1 
ATOM   371  O O    . MET A 1 29  ? 35.76821 6.07217   12.11694 1.000 20.17339  ? 26  MET A O    1 
ATOM   372  C CB   . MET A 1 29  ? 35.70049 2.88595   12.88113 1.000 17.14832  ? 26  MET A CB   1 
ATOM   373  C CG   . MET A 1 29  ? 36.61789 1.68887   12.63395 1.000 20.33737  ? 26  MET A CG   1 
ATOM   374  S SD   . MET A 1 29  ? 35.79068 0.32553   11.78768 1.000 22.10985  ? 26  MET A SD   1 
ATOM   375  C CE   . MET A 1 29  ? 34.67676 -0.29823  12.99579 1.000 21.36525  ? 26  MET A CE   1 
ATOM   376  H H    . MET A 1 29  ? 36.50172 3.30287   15.16326 1.000 21.19369  ? 26  MET A H    1 
ATOM   377  H HA   . MET A 1 29  ? 37.25828 4.20538   12.83809 1.000 23.14376  ? 26  MET A HA   1 
ATOM   378  H HB2  . MET A 1 29  ? 35.05227 2.62975   13.55572 1.000 20.59696  ? 26  MET A HB2  1 
ATOM   379  H HB3  . MET A 1 29  ? 35.24852 3.09151   12.04784 1.000 20.59696  ? 26  MET A HB3  1 
ATOM   380  H HG2  . MET A 1 29  ? 37.36447 1.97281   12.08359 1.000 24.42383  ? 26  MET A HG2  1 
ATOM   381  H HG3  . MET A 1 29  ? 36.94114 1.35864   13.48680 1.000 24.42383  ? 26  MET A HG3  1 
ATOM   382  H HE1  . MET A 1 29  ? 34.20996 -1.06526  12.62882 1.000 25.65728  ? 26  MET A HE1  1 
ATOM   383  H HE2  . MET A 1 29  ? 35.17931 -0.56210  13.78238 1.000 25.65728  ? 26  MET A HE2  1 
ATOM   384  H HE3  . MET A 1 29  ? 34.04060 0.39644   13.22736 1.000 25.65728  ? 26  MET A HE3  1 
ATOM   385  N N    . ARG A 1 30  ? 34.66028 5.67120   14.04196 1.000 17.52108  ? 27  ARG A N    1 
ATOM   386  C CA   . ARG A 1 30  ? 33.86126 6.88367   13.88707 1.000 19.08616  ? 27  ARG A CA   1 
ATOM   387  C C    . ARG A 1 30  ? 34.71137 8.13758   14.06536 1.000 19.84052  ? 27  ARG A C    1 
ATOM   388  O O    . ARG A 1 30  ? 34.46437 9.14782   13.39899 1.000 20.35742  ? 27  ARG A O    1 
ATOM   389  C CB   . ARG A 1 30  ? 32.68651 6.86758   14.85477 1.000 19.95741  ? 27  ARG A CB   1 
ATOM   390  C CG   . ARG A 1 30  ? 31.56432 5.92407   14.40868 1.000 21.19459  ? 27  ARG A CG   1 
ATOM   391  C CD   . ARG A 1 30  ? 30.41244 5.84619   15.39345 1.000 20.30363  ? 27  ARG A CD   1 
ATOM   392  N NE   . ARG A 1 30  ? 29.31018 5.04486   14.86711 1.000 22.89519  ? 27  ARG A NE   1 
ATOM   393  C CZ   . ARG A 1 30  ? 28.41218 4.41346   15.61278 1.000 23.32924  ? 27  ARG A CZ   1 
ATOM   394  N NH1  . ARG A 1 30  ? 28.45192 4.46159   16.93090 1.000 22.05306  ? 27  ARG A NH1  1 
ATOM   395  N NH2  . ARG A 1 30  ? 27.45433 3.70674   15.01999 1.000 21.91212  ? 27  ARG A NH2  1 
ATOM   396  H H    . ARG A 1 30  ? 34.47709 5.19784   14.73620 1.000 21.04427  ? 27  ARG A H    1 
ATOM   397  H HA   . ARG A 1 30  ? 33.49094 6.90841   12.99088 1.000 22.92237  ? 27  ARG A HA   1 
ATOM   398  H HB2  . ARG A 1 30  ? 32.99826 6.57337   15.72491 1.000 23.96788  ? 27  ARG A HB2  1 
ATOM   399  H HB3  . ARG A 1 30  ? 32.31848 7.76272   14.91945 1.000 23.96788  ? 27  ARG A HB3  1 
ATOM   400  H HG2  . ARG A 1 30  ? 31.20962 6.23685   13.56177 1.000 25.45248  ? 27  ARG A HG2  1 
ATOM   401  H HG3  . ARG A 1 30  ? 31.92781 5.03058   14.30644 1.000 25.45248  ? 27  ARG A HG3  1 
ATOM   402  H HD2  . ARG A 1 30  ? 30.72117 5.43662   16.21676 1.000 24.38334  ? 27  ARG A HD2  1 
ATOM   403  H HD3  . ARG A 1 30  ? 30.08143 6.74040   15.57155 1.000 24.38334  ? 27  ARG A HD3  1 
ATOM   404  H HE   . ARG A 1 30  ? 29.23807 4.97747   14.01280 1.000 27.49322  ? 27  ARG A HE   1 
ATOM   405  H HH11 . ARG A 1 30  ? 29.07018 4.90988   17.32637 1.000 26.48265  ? 27  ARG A HH11 1 
ATOM   406  H HH12 . ARG A 1 30  ? 27.85957 4.04467   17.39447 1.000 26.48265  ? 27  ARG A HH12 1 
ATOM   407  H HH21 . ARG A 1 30  ? 27.42128 3.66230   14.16178 1.000 26.31352  ? 27  ARG A HH21 1 
ATOM   408  H HH22 . ARG A 1 30  ? 26.86792 3.29414   15.49484 1.000 26.31352  ? 27  ARG A HH22 1 
ATOM   409  N N    . ARG A 1 31  ? 35.74415 8.08153   14.91088 1.000 19.93735  ? 28  ARG A N    1 
ATOM   410  C CA   . ARG A 1 31  ? 36.69693 9.18561   14.97608 1.000 21.14556  ? 28  ARG A CA   1 
ATOM   411  C C    . ARG A 1 31  ? 37.39202 9.39388   13.63448 1.000 20.19785  ? 28  ARG A C    1 
ATOM   412  O O    . ARG A 1 31  ? 37.78211 10.51954  13.30025 1.000 22.01542  ? 28  ARG A O    1 
ATOM   413  C CB   . ARG A 1 31  ? 37.73436 8.92417   16.06720 1.000 20.69005  ? 28  ARG A CB   1 
ATOM   414  C CG   . ARG A 1 31  ? 37.21904 9.10733   17.47934 1.000 21.94324  ? 28  ARG A CG   1 
ATOM   415  C CD   . ARG A 1 31  ? 38.26050 8.64008   18.50204 1.000 21.50162  ? 28  ARG A CD   1 
ATOM   416  N NE   . ARG A 1 31  ? 37.81198 8.85176   19.87515 1.000 21.32136  ? 28  ARG A NE   1 
ATOM   417  C CZ   . ARG A 1 31  ? 38.25167 9.82187   20.66401 1.000 23.22723  ? 28  ARG A CZ   1 
ATOM   418  N NH1  . ARG A 1 31  ? 39.19167 10.66192  20.26331 1.000 20.71836  ? 28  ARG A NH1  1 
ATOM   419  N NH2  . ARG A 1 31  ? 37.74506 9.94356   21.89026 1.000 22.17047  ? 28  ARG A NH2  1 
ATOM   420  H H    . ARG A 1 31  ? 35.91066 7.42869   15.44537 1.000 23.94380  ? 28  ARG A H    1 
ATOM   421  H HA   . ARG A 1 31  ? 36.21893 9.99797   15.20519 1.000 25.39365  ? 28  ARG A HA   1 
ATOM   422  H HB2  . ARG A 1 31  ? 38.04537 8.00906   15.98505 1.000 24.84704  ? 28  ARG A HB2  1 
ATOM   423  H HB3  . ARG A 1 31  ? 38.47468 9.53856   15.94334 1.000 24.84704  ? 28  ARG A HB3  1 
ATOM   424  H HG2  . ARG A 1 31  ? 37.03202 10.04598  17.63701 1.000 26.35087  ? 28  ARG A HG2  1 
ATOM   425  H HG3  . ARG A 1 31  ? 36.41178 8.58332   17.60037 1.000 26.35087  ? 28  ARG A HG3  1 
ATOM   426  H HD2  . ARG A 1 31  ? 38.42488 7.69195   18.37979 1.000 25.82093  ? 28  ARG A HD2  1 
ATOM   427  H HD3  . ARG A 1 31  ? 39.08217 9.13878   18.37145 1.000 25.82093  ? 28  ARG A HD3  1 
ATOM   428  H HE   . ARG A 1 31  ? 37.22354 8.31122   20.19320 1.000 25.60461  ? 28  ARG A HE   1 
ATOM   429  H HH11 . ARG A 1 31  ? 39.53034 10.58480  19.47657 1.000 24.88102  ? 28  ARG A HH11 1 
ATOM   430  H HH12 . ARG A 1 31  ? 39.46412 11.28518  20.78955 1.000 24.88102  ? 28  ARG A HH12 1 
ATOM   431  H HH21 . ARG A 1 31  ? 37.13987 9.39617   22.16176 1.000 26.62354  ? 28  ARG A HH21 1 
ATOM   432  H HH22 . ARG A 1 31  ? 38.02325 10.56949  22.41028 1.000 26.62354  ? 28  ARG A HH22 1 
ATOM   433  N N    . ALA A 1 32  ? 37.55943 8.32319   12.85752 1.000 21.96178  ? 29  ALA A N    1 
ATOM   434  C CA   . ALA A 1 32  ? 38.19695 8.39313   11.54683 1.000 23.25436  ? 29  ALA A CA   1 
ATOM   435  C C    . ALA A 1 32  ? 37.23060 8.78875   10.43870 1.000 24.32428  ? 29  ALA A C    1 
ATOM   436  O O    . ALA A 1 32  ? 37.62774 8.82794   9.26955  1.000 26.66066  ? 29  ALA A O    1 
ATOM   437  C CB   . ALA A 1 32  ? 38.83726 7.04729   11.20715 1.000 24.45898  ? 29  ALA A CB   1 
ATOM   438  H H    . ALA A 1 32  ? 37.30662 7.52996   13.07308 1.000 26.37312  ? 29  ALA A H    1 
ATOM   439  H HA   . ALA A 1 32  ? 38.89968 9.06091   11.58059 1.000 27.92421  ? 29  ALA A HA   1 
ATOM   440  H HB1  . ALA A 1 32  ? 39.25878 7.10910   10.33571 1.000 29.36976  ? 29  ALA A HB1  1 
ATOM   441  H HB2  . ALA A 1 32  ? 39.50126 6.83433   11.88142 1.000 29.36976  ? 29  ALA A HB2  1 
ATOM   442  H HB3  . ALA A 1 32  ? 38.14858 6.36432   11.19378 1.000 29.36976  ? 29  ALA A HB3  1 
ATOM   443  N N    . GLY A 1 33  ? 35.98562 9.10728   10.77156 1.000 23.38823  ? 30  GLY A N    1 
ATOM   444  C CA   . GLY A 1 33  ? 35.02629 9.50587   9.75905  1.000 26.68373  ? 30  GLY A CA   1 
ATOM   445  C C    . GLY A 1 33  ? 34.35894 8.35905   9.03756  1.000 28.35466  ? 30  GLY A C    1 
ATOM   446  O O    . GLY A 1 33  ? 33.63825 8.59424   8.06334  1.000 25.69183  ? 30  GLY A O    1 
ATOM   447  H H    . GLY A 1 33  ? 35.67617 9.09962   11.57392 1.000 28.08486  ? 30  GLY A H    1 
ATOM   448  H HA2  . GLY A 1 33  ? 34.33163 10.03621  10.17986 1.000 32.03946  ? 30  GLY A HA2  1 
ATOM   449  H HA3  . GLY A 1 33  ? 35.48064 10.04926  9.09633  1.000 32.03946  ? 30  GLY A HA3  1 
ATOM   450  N N    . ILE A 1 34  ? 34.57219 7.12727   9.48302  1.000 24.78044  ? 31  ILE A N    1 
ATOM   451  C CA   . ILE A 1 34  ? 33.94152 5.96707   8.86722  1.000 25.18971  ? 31  ILE A CA   1 
ATOM   452  C C    . ILE A 1 34  ? 32.50344 5.86570   9.35321  1.000 26.06912  ? 31  ILE A C    1 
ATOM   453  O O    . ILE A 1 34  ? 32.20578 6.10792   10.52781 1.000 23.67741  ? 31  ILE A O    1 
ATOM   454  C CB   . ILE A 1 34  ? 34.74016 4.68967   9.19124  1.000 23.64186  ? 31  ILE A CB   1 
ATOM   455  C CG1  . ILE A 1 34  ? 36.16526 4.79255   8.62468  1.000 25.50640  ? 31  ILE A CG1  1 
ATOM   456  C CG2  . ILE A 1 34  ? 34.01666 3.47077   8.69618  1.000 25.82283  ? 31  ILE A CG2  1 
ATOM   457  C CD1  . ILE A 1 34  ? 37.14991 3.80901   9.24073  1.000 26.58821  ? 31  ILE A CD1  1 
ATOM   458  H H    . ILE A 1 34  ? 35.08316 6.93465   10.14740 1.000 29.75551  ? 31  ILE A H    1 
ATOM   459  H HA   . ILE A 1 34  ? 33.92984 6.07946   7.90382  1.000 30.24663  ? 31  ILE A HA   1 
ATOM   460  H HB   . ILE A 1 34  ? 34.81681 4.60371   10.15438 1.000 28.38922  ? 31  ILE A HB   1 
ATOM   461  H HG12 . ILE A 1 34  ? 36.13368 4.61967   7.67073  1.000 30.62666  ? 31  ILE A HG12 1 
ATOM   462  H HG13 . ILE A 1 34  ? 36.50103 5.68768   8.78869  1.000 30.62666  ? 31  ILE A HG13 1 
ATOM   463  H HG21 . ILE A 1 34  ? 34.59339 2.69766   8.79904  1.000 31.00638  ? 31  ILE A HG21 1 
ATOM   464  H HG22 . ILE A 1 34  ? 33.20694 3.35099   9.21667  1.000 31.00638  ? 31  ILE A HG22 1 
ATOM   465  H HG23 . ILE A 1 34  ? 33.79311 3.59452   7.76044  1.000 31.00638  ? 31  ILE A HG23 1 
ATOM   466  H HD11 . ILE A 1 34  ? 38.04878 4.04746   8.96491  1.000 31.92483  ? 31  ILE A HD11 1 
ATOM   467  H HD12 . ILE A 1 34  ? 37.07772 3.85329   10.20702 1.000 31.92483  ? 31  ILE A HD12 1 
ATOM   468  H HD13 . ILE A 1 34  ? 36.93617 2.91405   8.93372  1.000 31.92483  ? 31  ILE A HD13 1 
ATOM   469  N N    . LYS A 1 35  ? 31.59792 5.51708   8.44515  1.000 26.82320  ? 32  LYS A N    1 
ATOM   470  C CA   A LYS A 1 35  ? 30.20388 5.27741   8.80443  0.261 30.81981  ? 32  LYS A CA   1 
ATOM   471  C CA   B LYS A 1 35  ? 30.20756 5.27947   8.81106  0.739 29.52989  ? 32  LYS A CA   1 
ATOM   472  C C    . LYS A 1 35  ? 30.08645 3.84697   9.31496  1.000 26.74872  ? 32  LYS A C    1 
ATOM   473  O O    . LYS A 1 35  ? 30.19348 2.89407   8.53405  1.000 27.12528  ? 32  LYS A O    1 
ATOM   474  C CB   A LYS A 1 35  ? 29.28367 5.51313   7.60890  0.261 34.52035  ? 32  LYS A CB   1 
ATOM   475  C CB   B LYS A 1 35  ? 29.29076 5.52515   7.61683  0.739 33.92725  ? 32  LYS A CB   1 
ATOM   476  C CG   A LYS A 1 35  ? 28.93567 6.97507   7.36987  0.261 40.91062  ? 32  LYS A CG   1 
ATOM   477  C CG   B LYS A 1 35  ? 27.82253 5.66629   7.98606  0.739 39.22504  ? 32  LYS A CG   1 
ATOM   478  C CD   A LYS A 1 35  ? 27.49046 7.12853   6.90157  0.261 56.31067  ? 32  LYS A CD   1 
ATOM   479  C CD   B LYS A 1 35  ? 26.94235 5.85127   6.74134  0.739 59.57906  ? 32  LYS A CD   1 
ATOM   480  C CE   A LYS A 1 35  ? 27.40282 7.54419   5.43552  0.261 64.02423  ? 32  LYS A CE   1 
ATOM   481  C CE   B LYS A 1 35  ? 27.43609 7.00048   5.85662  0.739 69.56132  ? 32  LYS A CE   1 
ATOM   482  N NZ   A LYS A 1 35  ? 25.98551 7.61968   4.96522  0.261 66.58869  ? 32  LYS A NZ   1 
ATOM   483  N NZ   B LYS A 1 35  ? 26.50902 7.28287   4.71325  0.739 73.27974  ? 32  LYS A NZ   1 
ATOM   484  H H    A LYS A 1 35  ? 31.76683 5.41204   7.60846  0.261 32.20683  ? 32  LYS A H    1 
ATOM   485  H H    B LYS A 1 35  ? 31.76516 5.41155   7.60819  0.739 32.20683  ? 32  LYS A H    1 
ATOM   486  H HA   A LYS A 1 35  ? 29.93766 5.89136   9.50664  0.261 37.00276  ? 32  LYS A HA   1 
ATOM   487  H HA   B LYS A 1 35  ? 29.94411 5.88700   9.51987  0.739 35.45485  ? 32  LYS A HA   1 
ATOM   488  H HB2  A LYS A 1 35  ? 29.72155 5.18023   6.80994  0.261 41.44340  ? 32  LYS A HB2  1 
ATOM   489  H HB2  B LYS A 1 35  ? 29.56512 6.34520   7.17736  0.739 40.73168  ? 32  LYS A HB2  1 
ATOM   490  H HB3  A LYS A 1 35  ? 28.45376 5.03326   7.75679  0.261 41.44340  ? 32  LYS A HB3  1 
ATOM   491  H HB3  B LYS A 1 35  ? 29.37082 4.77752   7.00402  0.739 40.73168  ? 32  LYS A HB3  1 
ATOM   492  H HG2  A LYS A 1 35  ? 29.04426 7.47172   8.19597  0.261 49.11172  ? 32  LYS A HG2  1 
ATOM   493  H HG2  B LYS A 1 35  ? 27.52982 4.86621   8.44983  0.739 47.08902  ? 32  LYS A HG2  1 
ATOM   494  H HG3  A LYS A 1 35  ? 29.51951 7.33788   6.68546  0.261 49.11172  ? 32  LYS A HG3  1 
ATOM   495  H HG3  B LYS A 1 35  ? 27.70839 6.44161   8.55768  0.739 47.08902  ? 32  LYS A HG3  1 
ATOM   496  H HD2  A LYS A 1 35  ? 27.03040 6.28067   7.00341  0.261 67.59179  ? 32  LYS A HD2  1 
ATOM   497  H HD2  B LYS A 1 35  ? 26.95702 5.03628   6.21554  0.739 71.51386  ? 32  LYS A HD2  1 
ATOM   498  H HD3  A LYS A 1 35  ? 27.05271 7.80976   7.43561  0.261 67.59179  ? 32  LYS A HD3  1 
ATOM   499  H HD3  B LYS A 1 35  ? 26.03452 6.05089   7.01865  0.739 71.51386  ? 32  LYS A HD3  1 
ATOM   500  H HE2  A LYS A 1 35  ? 27.80650 8.41939   5.32613  0.261 76.84806  ? 32  LYS A HE2  1 
ATOM   501  H HE2  B LYS A 1 35  ? 27.50673 7.80584   6.39263  0.739 83.49256  ? 32  LYS A HE2  1 
ATOM   502  H HE3  A LYS A 1 35  ? 27.87008 6.89272   4.88948  0.261 76.84806  ? 32  LYS A HE3  1 
ATOM   503  H HE3  B LYS A 1 35  ? 28.30379 6.76867   5.49020  0.739 83.49256  ? 32  LYS A HE3  1 
ATOM   504  H HZ1  A LYS A 1 35  ? 25.95925 7.90379   4.12219  0.261 79.92541  ? 32  LYS A HZ1  1 
ATOM   505  H HZ1  B LYS A 1 35  ? 26.83108 7.94806   4.21737  0.739 87.95467  ? 32  LYS A HZ1  1 
ATOM   506  H HZ2  A LYS A 1 35  ? 25.60636 6.81579   5.01104  0.261 79.92541  ? 32  LYS A HZ2  1 
ATOM   507  H HZ2  B LYS A 1 35  ? 26.42411 6.55791   4.20402  0.739 87.95467  ? 32  LYS A HZ2  1 
ATOM   508  H HZ3  A LYS A 1 35  ? 25.52530 8.18557   5.47519  0.261 79.92541  ? 32  LYS A HZ3  1 
ATOM   509  H HZ3  B LYS A 1 35  ? 25.70703 7.51469   5.02174  0.739 87.95467  ? 32  LYS A HZ3  1 
ATOM   510  N N    . VAL A 1 36  ? 29.86408 3.69231   10.61901 1.000 26.34276  ? 33  VAL A N    1 
ATOM   511  C CA   . VAL A 1 36  ? 29.83763 2.39081   11.27298 1.000 23.87818  ? 33  VAL A CA   1 
ATOM   512  C C    . VAL A 1 36  ? 28.39999 2.02509   11.60132 1.000 25.86617  ? 33  VAL A C    1 
ATOM   513  O O    . VAL A 1 36  ? 27.65106 2.83444   12.16445 1.000 25.28555  ? 33  VAL A O    1 
ATOM   514  C CB   . VAL A 1 36  ? 30.69588 2.38737   12.55041 1.000 21.90612  ? 33  VAL A CB   1 
ATOM   515  C CG1  . VAL A 1 36  ? 30.64375 1.03111   13.22173 1.000 22.69704  ? 33  VAL A CG1  1 
ATOM   516  C CG2  . VAL A 1 36  ? 32.12408 2.81642   12.23537 1.000 21.13511  ? 33  VAL A CG2  1 
ATOM   517  H H    . VAL A 1 36  ? 29.72216 4.34697   11.15834 1.000 31.63029  ? 33  VAL A H    1 
ATOM   518  H HA   . VAL A 1 36  ? 30.18470 1.72831   10.65530 1.000 28.67280  ? 33  VAL A HA   1 
ATOM   519  H HB   . VAL A 1 36  ? 30.33692 3.03130   13.18080 1.000 26.30632  ? 33  VAL A HB   1 
ATOM   520  H HG11 . VAL A 1 36  ? 31.34010 0.98524   13.89545 1.000 27.25543  ? 33  VAL A HG11 1 
ATOM   521  H HG12 . VAL A 1 36  ? 29.77428 0.91720   13.63640 1.000 27.25543  ? 33  VAL A HG12 1 
ATOM   522  H HG13 . VAL A 1 36  ? 30.78426 0.34230   12.55336 1.000 27.25543  ? 33  VAL A HG13 1 
ATOM   523  H HG21 . VAL A 1 36  ? 32.66379 2.73012   13.03672 1.000 25.38111  ? 33  VAL A HG21 1 
ATOM   524  H HG22 . VAL A 1 36  ? 32.47801 2.24601   11.53518 1.000 25.38111  ? 33  VAL A HG22 1 
ATOM   525  H HG23 . VAL A 1 36  ? 32.11819 3.73982   11.93839 1.000 25.38111  ? 33  VAL A HG23 1 
ATOM   526  N N    . THR A 1 37  ? 28.03162 0.79345   11.28231 1.000 21.84964  ? 34  THR A N    1 
ATOM   527  C CA   . THR A 1 37  ? 26.75103 0.22374   11.67200 1.000 24.16669  ? 34  THR A CA   1 
ATOM   528  C C    . THR A 1 37  ? 26.99557 -0.93073  12.63412 1.000 23.20105  ? 34  THR A C    1 
ATOM   529  O O    . THR A 1 37  ? 27.59140 -1.94364  12.25186 1.000 24.45088  ? 34  THR A O    1 
ATOM   530  C CB   . THR A 1 37  ? 25.96247 -0.26043  10.45308 1.000 28.16437  ? 34  THR A CB   1 
ATOM   531  O OG1  . THR A 1 37  ? 25.72323 0.84739   9.58408  1.000 28.25944  ? 34  THR A OG1  1 
ATOM   532  C CG2  . THR A 1 37  ? 24.62699 -0.87098  10.89782 1.000 28.96846  ? 34  THR A CG2  1 
ATOM   533  H H    . THR A 1 37  ? 28.52116 0.25248   10.82700 1.000 26.23855  ? 34  THR A H    1 
ATOM   534  H HA   . THR A 1 37  ? 26.22755 0.90279   12.12560 1.000 29.01901  ? 34  THR A HA   1 
ATOM   535  H HB   . THR A 1 37  ? 26.46285 -0.94133  9.97675  1.000 33.81623  ? 34  THR A HB   1 
ATOM   536  H HG1  . THR A 1 37  ? 25.39550 0.57821   8.85900  1.000 33.93031  ? 34  THR A HG1  1 
ATOM   537  H HG21 . THR A 1 37  ? 24.06123 -1.02940  10.12599 1.000 34.78114  ? 34  THR A HG21 1 
ATOM   538  H HG22 . THR A 1 37  ? 24.78247 -1.71363  11.35243 1.000 34.78114  ? 34  THR A HG22 1 
ATOM   539  H HG23 . THR A 1 37  ? 24.17096 -0.26597  11.50354 1.000 34.78114  ? 34  THR A HG23 1 
ATOM   540  N N    . VAL A 1 38  ? 26.52912 -0.77648  13.87009 1.000 22.09253  ? 35  VAL A N    1 
ATOM   541  C CA   . VAL A 1 38  ? 26.54987 -1.84304  14.86329 1.000 23.44747  ? 35  VAL A CA   1 
ATOM   542  C C    . VAL A 1 38  ? 25.24541 -2.61091  14.70409 1.000 24.14406  ? 35  VAL A C    1 
ATOM   543  O O    . VAL A 1 38  ? 24.17133 -2.11248  15.05000 1.000 25.06338  ? 35  VAL A O    1 
ATOM   544  C CB   . VAL A 1 38  ? 26.71380 -1.29186  16.28515 1.000 22.42854  ? 35  VAL A CB   1 
ATOM   545  C CG1  . VAL A 1 38  ? 26.66932 -2.40816  17.29407 1.000 24.76606  ? 35  VAL A CG1  1 
ATOM   546  C CG2  . VAL A 1 38  ? 28.04866 -0.52106  16.39775 1.000 21.70584  ? 35  VAL A CG2  1 
ATOM   547  H H    . VAL A 1 38  ? 26.18712 -0.04406  14.16370 1.000 26.53001  ? 35  VAL A H    1 
ATOM   548  H HA   . VAL A 1 38  ? 27.29385 -2.44202  14.69410 1.000 28.15594  ? 35  VAL A HA   1 
ATOM   549  H HB   . VAL A 1 38  ? 25.98290 -0.68356  16.47659 1.000 26.93323  ? 35  VAL A HB   1 
ATOM   550  H HG11 . VAL A 1 38  ? 26.94630 -2.06441  18.15780 1.000 29.73825  ? 35  VAL A HG11 1 
ATOM   551  H HG12 . VAL A 1 38  ? 25.76262 -2.74844  17.34878 1.000 29.73825  ? 35  VAL A HG12 1 
ATOM   552  H HG13 . VAL A 1 38  ? 27.27106 -3.11418  17.01061 1.000 29.73825  ? 35  VAL A HG13 1 
ATOM   553  H HG21 . VAL A 1 38  ? 28.15842 -0.21124  17.31037 1.000 26.06599  ? 35  VAL A HG21 1 
ATOM   554  H HG22 . VAL A 1 38  ? 28.77754 -1.11541  16.16029 1.000 26.06599  ? 35  VAL A HG22 1 
ATOM   555  H HG23 . VAL A 1 38  ? 28.02829 0.23597   15.79163 1.000 26.06599  ? 35  VAL A HG23 1 
ATOM   556  N N    . ALA A 1 39  ? 25.33809 -3.82060  14.17178 1.000 23.86999  ? 36  ALA A N    1 
ATOM   557  C CA   . ALA A 1 39  ? 24.17577 -4.60922  13.80313 1.000 24.07432  ? 36  ALA A CA   1 
ATOM   558  C C    . ALA A 1 39  ? 24.00693 -5.74273  14.79386 1.000 25.09275  ? 36  ALA A C    1 
ATOM   559  O O    . ALA A 1 39  ? 24.94958 -6.49744  15.04423 1.000 25.83329  ? 36  ALA A O    1 
ATOM   560  C CB   . ALA A 1 39  ? 24.32044 -5.16491  12.38555 1.000 26.79308  ? 36  ALA A CB   1 
ATOM   561  H H    . ALA A 1 39  ? 26.08492 -4.21545  14.01071 1.000 28.66297  ? 36  ALA A H    1 
ATOM   562  H HA   . ALA A 1 39  ? 23.38164 -4.05303  13.83338 1.000 28.90817  ? 36  ALA A HA   1 
ATOM   563  H HB1  . ALA A 1 39  ? 23.53094 -5.68480  12.16805 1.000 32.17068  ? 36  ALA A HB1  1 
ATOM   564  H HB2  . ALA A 1 39  ? 24.41113 -4.42555  11.76425 1.000 32.17068  ? 36  ALA A HB2  1 
ATOM   565  H HB3  . ALA A 1 39  ? 25.10886 -5.72860  12.34625 1.000 32.17068  ? 36  ALA A HB3  1 
ATOM   566  N N    . GLY A 1 40  ? 22.80659 -5.85154  15.35693 1.000 24.12793  ? 37  GLY A N    1 
ATOM   567  C CA   . GLY A 1 40  ? 22.51050 -6.93158  16.27548 1.000 25.04458  ? 37  GLY A CA   1 
ATOM   568  C C    . GLY A 1 40  ? 22.22374 -8.21507  15.52765 1.000 30.79197  ? 37  GLY A C    1 
ATOM   569  O O    . GLY A 1 40  ? 21.38982 -8.24549  14.61754 1.000 28.75091  ? 37  GLY A O    1 
ATOM   570  H H    . GLY A 1 40  ? 22.15126 -5.31157  15.22063 1.000 28.97249  ? 37  GLY A H    1 
ATOM   571  H HA2  . GLY A 1 40  ? 23.26757 -7.07683  16.86426 1.000 30.07248  ? 37  GLY A HA2  1 
ATOM   572  H HA3  . GLY A 1 40  ? 21.73412 -6.70260  16.80999 1.000 30.07248  ? 37  GLY A HA3  1 
ATOM   573  N N    . LEU A 1 41  ? 22.93278 -9.28155  15.90197 1.000 27.65606  ? 38  LEU A N    1 
ATOM   574  C CA   . LEU A 1 41  ? 22.73354 -10.57291 15.25103 1.000 34.11171  ? 38  LEU A CA   1 
ATOM   575  C C    . LEU A 1 41  ? 21.28886 -11.04345 15.37489 1.000 35.48703  ? 38  LEU A C    1 
ATOM   576  O O    . LEU A 1 41  ? 20.70680 -11.54376 14.40545 1.000 36.09780  ? 38  LEU A O    1 
ATOM   577  C CB   . LEU A 1 41  ? 23.68389 -11.60949 15.85230 1.000 30.68930  ? 38  LEU A CB   1 
ATOM   578  C CG   . LEU A 1 41  ? 23.63442 -13.02977 15.28826 1.000 36.01520  ? 38  LEU A CG   1 
ATOM   579  C CD1  . LEU A 1 41  ? 24.05806 -13.03173 13.83795 1.000 39.84429  ? 38  LEU A CD1  1 
ATOM   580  C CD2  . LEU A 1 41  ? 24.51581 -13.95291 16.11307 1.000 36.73266  ? 38  LEU A CD2  1 
ATOM   581  H H    . LEU A 1 41  ? 23.52797 -9.28312  16.52273 1.000 33.20626  ? 38  LEU A H    1 
ATOM   582  H HA   . LEU A 1 41  ? 22.93772 -10.48024 14.30730 1.000 40.95303  ? 38  LEU A HA   1 
ATOM   583  H HB2  . LEU A 1 41  ? 24.59042 -11.28893 15.72449 1.000 36.84614  ? 38  LEU A HB2  1 
ATOM   584  H HB3  . LEU A 1 41  ? 23.48648 -11.67743 16.79957 1.000 36.84614  ? 38  LEU A HB3  1 
ATOM   585  H HG   . LEU A 1 41  ? 22.72541 -13.36526 15.33351 1.000 43.23723  ? 38  LEU A HG   1 
ATOM   586  H HD11 . LEU A 1 41  ? 23.26688 -12.99772 13.27780 1.000 47.83212  ? 38  LEU A HD11 1 
ATOM   587  H HD12 . LEU A 1 41  ? 24.61537 -12.25563 13.67070 1.000 47.83212  ? 38  LEU A HD12 1 
ATOM   588  H HD13 . LEU A 1 41  ? 24.55758 -13.84307 13.65596 1.000 47.83212  ? 38  LEU A HD13 1 
ATOM   589  H HD21 . LEU A 1 41  ? 24.45166 -14.85268 15.75642 1.000 44.09818  ? 38  LEU A HD21 1 
ATOM   590  H HD22 . LEU A 1 41  ? 25.43318 -13.64180 16.06281 1.000 44.09818  ? 38  LEU A HD22 1 
ATOM   591  H HD23 . LEU A 1 41  ? 24.21206 -13.93977 17.03419 1.000 44.09818  ? 38  LEU A HD23 1 
ATOM   592  N N    . ALA A 1 42  ? 20.68965 -10.87759 16.54994 1.000 35.32767  ? 39  ALA A N    1 
ATOM   593  C CA   . ALA A 1 42  ? 19.36032 -11.40234 16.82613 1.000 38.96355  ? 39  ALA A CA   1 
ATOM   594  C C    . ALA A 1 42  ? 18.23827 -10.40372 16.56467 1.000 39.41097  ? 39  ALA A C    1 
ATOM   595  O O    . ALA A 1 42  ? 17.06847 -10.77351 16.68127 1.000 43.78441  ? 39  ALA A O    1 
ATOM   596  C CB   . ALA A 1 42  ? 19.29009 -11.88175 18.27980 1.000 42.20070  ? 39  ALA A CB   1 
ATOM   597  H H    . ALA A 1 42  ? 21.04016 -10.45723 17.21329 1.000 42.41219  ? 39  ALA A H    1 
ATOM   598  H HA   . ALA A 1 42  ? 19.20566 -12.16110 16.24194 1.000 46.77525  ? 39  ALA A HA   1 
ATOM   599  H HB1  . ALA A 1 42  ? 18.40219 -12.23098 18.45462 1.000 50.65982  ? 39  ALA A HB1  1 
ATOM   600  H HB2  . ALA A 1 42  ? 19.95189 -12.57791 18.41507 1.000 50.65982  ? 39  ALA A HB2  1 
ATOM   601  H HB3  . ALA A 1 42  ? 19.47278 -11.13279 18.86851 1.000 50.65982  ? 39  ALA A HB3  1 
ATOM   602  N N    . GLY A 1 43  ? 18.55187 -9.17548  16.20538 1.000 35.63410  ? 40  GLY A N    1 
ATOM   603  C CA   . GLY A 1 43  ? 17.56552 -8.14415  15.98653 1.000 38.72535  ? 40  GLY A CA   1 
ATOM   604  C C    . GLY A 1 43  ? 18.05052 -6.81754  16.53563 1.000 34.09710  ? 40  GLY A C    1 
ATOM   605  O O    . GLY A 1 43  ? 19.22832 -6.63794  16.84057 1.000 36.15503  ? 40  GLY A O    1 
ATOM   606  H H    . GLY A 1 43  ? 19.35902 -8.90737  16.07798 1.000 42.77990  ? 40  GLY A H    1 
ATOM   607  H HA2  . GLY A 1 43  ? 17.39745 -8.04656  15.03620 1.000 46.48940  ? 40  GLY A HA2  1 
ATOM   608  H HA3  . GLY A 1 43  ? 16.73687 -8.38236  16.43095 1.000 46.48940  ? 40  GLY A HA3  1 
ATOM   609  N N    . LYS A 1 44  ? 17.11205 -5.87612  16.66123 1.000 36.18754  ? 41  LYS A N    1 
ATOM   610  C CA   . LYS A 1 44  ? 17.37681 -4.51656  17.11696 1.000 38.70509  ? 41  LYS A CA   1 
ATOM   611  C C    . LYS A 1 44  ? 17.45129 -4.40434  18.63531 1.000 35.45229  ? 41  LYS A C    1 
ATOM   612  O O    . LYS A 1 44  ? 17.86379 -3.35834  19.13622 1.000 36.47989  ? 41  LYS A O    1 
ATOM   613  C CB   . LYS A 1 44  ? 16.28256 -3.58862  16.55531 1.000 43.56674  ? 41  LYS A CB   1 
ATOM   614  C CG   . LYS A 1 44  ? 16.34110 -2.13652  16.99398 1.000 88.10212  ? 41  LYS A CG   1 
ATOM   615  C CD   . LYS A 1 44  ? 17.08939 -1.25781  15.98939 1.000 69.42403  ? 41  LYS A CD   1 
ATOM   616  C CE   . LYS A 1 44  ? 16.69926 0.21888   16.13147 1.000 80.25118  ? 41  LYS A CE   1 
ATOM   617  N NZ   . LYS A 1 44  ? 15.25579 0.44976   15.80366 1.000 102.11375 ? 41  LYS A NZ   1 
ATOM   618  H H    . LYS A 1 44  ? 16.28164 -6.00816  16.48071 1.000 43.44403  ? 41  LYS A H    1 
ATOM   619  H HA   . LYS A 1 44  ? 18.23296 -4.21329  16.77648 1.000 46.46509  ? 41  LYS A HA   1 
ATOM   620  H HB2  . LYS A 1 44  ? 16.34729 -3.59694  15.58751 1.000 52.29907  ? 41  LYS A HB2  1 
ATOM   621  H HB3  . LYS A 1 44  ? 15.42051 -3.93588  16.83314 1.000 52.29907  ? 41  LYS A HB3  1 
ATOM   622  H HG2  . LYS A 1 44  ? 15.43798 -1.79343  17.08094 1.000 105.74153 ? 41  LYS A HG2  1 
ATOM   623  H HG3  . LYS A 1 44  ? 16.80112 -2.07953  17.84606 1.000 105.74153 ? 41  LYS A HG3  1 
ATOM   624  H HD2  . LYS A 1 44  ? 18.04399 -1.33671  16.14245 1.000 83.32781  ? 41  LYS A HD2  1 
ATOM   625  H HD3  . LYS A 1 44  ? 16.87304 -1.54464  15.08838 1.000 83.32781  ? 41  LYS A HD3  1 
ATOM   626  H HE2  . LYS A 1 44  ? 16.85176 0.50310   17.04627 1.000 96.32040  ? 41  LYS A HE2  1 
ATOM   627  H HE3  . LYS A 1 44  ? 17.23703 0.75129   15.52463 1.000 96.32040  ? 41  LYS A HE3  1 
ATOM   628  H HZ1  . LYS A 1 44  ? 14.73902 0.07205   16.42203 1.000 122.55549 ? 41  LYS A HZ1  1 
ATOM   629  H HZ2  . LYS A 1 44  ? 15.08519 1.32290   15.77870 1.000 122.55549 ? 41  LYS A HZ2  1 
ATOM   630  H HZ3  . LYS A 1 44  ? 15.06328 0.09505   15.01042 1.000 122.55549 ? 41  LYS A HZ3  1 
ATOM   631  N N    . ASP A 1 45  ? 17.09712 -5.45035  19.37425 1.000 34.91495  ? 42  ASP A N    1 
ATOM   632  C CA   . ASP A 1 45  ? 17.00629 -5.35219  20.81757 1.000 34.29252  ? 42  ASP A CA   1 
ATOM   633  C C    . ASP A 1 45  ? 18.38333 -5.16755  21.45704 1.000 32.90853  ? 42  ASP A C    1 
ATOM   634  O O    . ASP A 1 45  ? 19.41116 -5.54036  20.88491 1.000 28.03171  ? 42  ASP A O    1 
ATOM   635  C CB   . ASP A 1 45  ? 16.33330 -6.59729  21.38792 1.000 42.57025  ? 42  ASP A CB   1 
ATOM   636  C CG   . ASP A 1 45  ? 14.85423 -6.68060  21.02793 1.000 54.27846  ? 42  ASP A CG   1 
ATOM   637  O OD1  . ASP A 1 45  ? 14.19651 -5.61896  20.92976 1.000 49.77986  ? 42  ASP A OD1  1 
ATOM   638  O OD2  . ASP A 1 45  ? 14.35519 -7.80707  20.84044 1.000 58.39655  ? 42  ASP A OD2  1 
ATOM   639  H H    . ASP A 1 45  ? 16.90480 -6.22744  19.06001 1.000 41.91692  ? 42  ASP A H    1 
ATOM   640  H HA   . ASP A 1 45  ? 16.47230 -4.57492  21.04473 1.000 41.17001  ? 42  ASP A HA   1 
ATOM   641  H HB2  . ASP A 1 45  ? 16.77373 -7.38569  21.03388 1.000 51.10328  ? 42  ASP A HB2  1 
ATOM   642  H HB3  . ASP A 1 45  ? 16.40694 -6.58225  22.35500 1.000 51.10328  ? 42  ASP A HB3  1 
ATOM   643  N N    . PRO A 1 46  ? 18.42228 -4.57805  22.64977 1.000 31.86544  ? 43  PRO A N    1 
ATOM   644  C CA   . PRO A 1 46  ? 19.70800 -4.39465  23.33786 1.000 29.61214  ? 43  PRO A CA   1 
ATOM   645  C C    . PRO A 1 46  ? 20.40342 -5.72340  23.57938 1.000 29.71312  ? 43  PRO A C    1 
ATOM   646  O O    . PRO A 1 46  ? 19.76492 -6.74443  23.85438 1.000 30.12556  ? 43  PRO A O    1 
ATOM   647  C CB   . PRO A 1 46  ? 19.31980 -3.72753  24.66091 1.000 30.46732  ? 43  PRO A CB   1 
ATOM   648  C CG   . PRO A 1 46  ? 17.95851 -3.09689  24.39345 1.000 37.46292  ? 43  PRO A CG   1 
ATOM   649  C CD   . PRO A 1 46  ? 17.28397 -4.04391  23.42308 1.000 37.00823  ? 43  PRO A CD   1 
ATOM   650  H HA   . PRO A 1 46  ? 20.28599 -3.80546  22.82828 1.000 35.55355  ? 43  PRO A HA   1 
ATOM   651  H HB2  . PRO A 1 46  ? 19.26257 -4.39395  25.36341 1.000 36.57977  ? 43  PRO A HB2  1 
ATOM   652  H HB3  . PRO A 1 46  ? 19.97566 -3.05276  24.89637 1.000 36.57977  ? 43  PRO A HB3  1 
ATOM   653  H HG2  . PRO A 1 46  ? 17.45557 -3.02880  25.22008 1.000 44.97448  ? 43  PRO A HG2  1 
ATOM   654  H HG3  . PRO A 1 46  ? 18.07115 -2.21735  24.00024 1.000 44.97448  ? 43  PRO A HG3  1 
ATOM   655  H HD2  . PRO A 1 46  ? 16.82055 -4.75349  23.89494 1.000 44.42886  ? 43  PRO A HD2  1 
ATOM   656  H HD3  . PRO A 1 46  ? 16.66464 -3.56886  22.84720 1.000 44.42886  ? 43  PRO A HD3  1 
ATOM   657  N N    . VAL A 1 47  ? 21.73196 -5.69530  23.49357 1.000 26.95966  ? 44  VAL A N    1 
ATOM   658  C CA   . VAL A 1 47  ? 22.56049 -6.89578  23.54879 1.000 26.43210  ? 44  VAL A CA   1 
ATOM   659  C C    . VAL A 1 47  ? 23.37023 -6.88963  24.83820 1.000 24.79671  ? 44  VAL A C    1 
ATOM   660  O O    . VAL A 1 47  ? 24.06898 -5.91491  25.14314 1.000 22.80816  ? 44  VAL A O    1 
ATOM   661  C CB   . VAL A 1 47  ? 23.48696 -6.98902  22.32359 1.000 25.78246  ? 44  VAL A CB   1 
ATOM   662  C CG1  . VAL A 1 47  ? 24.42125 -8.18041  22.43966 1.000 25.40470  ? 44  VAL A CG1  1 
ATOM   663  C CG2  . VAL A 1 47  ? 22.67042 -7.07516  21.03947 1.000 28.03975  ? 44  VAL A CG2  1 
ATOM   664  H H    . VAL A 1 47  ? 22.18740 -4.97176  23.40043 1.000 32.37058  ? 44  VAL A H    1 
ATOM   665  H HA   . VAL A 1 47  ? 21.98133 -7.67370  23.56682 1.000 31.73751  ? 44  VAL A HA   1 
ATOM   666  H HB   . VAL A 1 47  ? 24.02929 -6.18563  22.28698 1.000 30.95793  ? 44  VAL A HB   1 
ATOM   667  H HG11 . VAL A 1 47  ? 24.82706 -8.34894  21.57490 1.000 30.50462  ? 44  VAL A HG11 1 
ATOM   668  H HG12 . VAL A 1 47  ? 25.10856 -7.98016  23.09419 1.000 30.50462  ? 44  VAL A HG12 1 
ATOM   669  H HG13 . VAL A 1 47  ? 23.91107 -8.95547  22.72232 1.000 30.50462  ? 44  VAL A HG13 1 
ATOM   670  H HG21 . VAL A 1 47  ? 23.27347 -7.19474  20.28918 1.000 33.66668  ? 44  VAL A HG21 1 
ATOM   671  H HG22 . VAL A 1 47  ? 22.06459 -7.83024  21.10051 1.000 33.66668  ? 44  VAL A HG22 1 
ATOM   672  H HG23 . VAL A 1 47  ? 22.16564 -6.25404  20.93053 1.000 33.66668  ? 44  VAL A HG23 1 
ATOM   673  N N    . GLN A 1 48  ? 23.27094 -7.97652  25.59147 1.000 23.81916  ? 45  GLN A N    1 
ATOM   674  C CA   . GLN A 1 48  ? 24.02040 -8.13959  26.82681 1.000 26.20599  ? 45  GLN A CA   1 
ATOM   675  C C    . GLN A 1 48  ? 25.37554 -8.75269  26.51245 1.000 25.47096  ? 45  GLN A C    1 
ATOM   676  O O    . GLN A 1 48  ? 25.45118 -9.89967  26.04907 1.000 25.89032  ? 45  GLN A O    1 
ATOM   677  C CB   . GLN A 1 48  ? 23.24997 -9.02154  27.80830 1.000 29.52087  ? 45  GLN A CB   1 
ATOM   678  C CG   . GLN A 1 48  ? 23.93687 -9.21621  29.14485 1.000 37.20906  ? 45  GLN A CG   1 
ATOM   679  C CD   . GLN A 1 48  ? 23.10590 -10.02567 30.12657 1.000 50.79378  ? 45  GLN A CD   1 
ATOM   680  O OE1  . GLN A 1 48  ? 22.48469 -11.02314 29.76256 1.000 49.68646  ? 45  GLN A OE1  1 
ATOM   681  N NE2  . GLN A 1 48  ? 23.08518 -9.58824  31.37933 1.000 66.36402  ? 45  GLN A NE2  1 
ATOM   682  H H    . GLN A 1 48  ? 22.76560 -8.64658  25.40375 1.000 28.60197  ? 45  GLN A H    1 
ATOM   683  H HA   . GLN A 1 48  ? 24.16085 -7.27199  27.23723 1.000 31.46617  ? 45  GLN A HA   1 
ATOM   684  H HB2  . GLN A 1 48  ? 22.38640 -8.61392  27.97857 1.000 35.44403  ? 45  GLN A HB2  1 
ATOM   685  H HB3  . GLN A 1 48  ? 23.13046 -9.89752  27.40922 1.000 35.44403  ? 45  GLN A HB3  1 
ATOM   686  H HG2  . GLN A 1 48  ? 24.77400 -9.68544  29.00369 1.000 44.66985  ? 45  GLN A HG2  1 
ATOM   687  H HG3  . GLN A 1 48  ? 24.10632 -8.34748  29.54172 1.000 44.66985  ? 45  GLN A HG3  1 
ATOM   688  H HE21 . GLN A 1 48  ? 23.52692 -8.88284  31.59585 1.000 79.65580  ? 45  GLN A HE21 1 
ATOM   689  H HE22 . GLN A 1 48  ? 22.63001 -10.01017 31.97465 1.000 79.65580  ? 45  GLN A HE22 1 
ATOM   690  N N    . CYS A 1 49  ? 26.43831 -7.98937  26.76723 1.000 23.32564  ? 46  CYS A N    1 
ATOM   691  C CA   . CYS A 1 49  ? 27.78118 -8.42350  26.44577 1.000 23.45844  ? 46  CYS A CA   1 
ATOM   692  C C    . CYS A 1 49  ? 28.35276 -9.27225  27.57891 1.000 22.53444  ? 46  CYS A C    1 
ATOM   693  O O    . CYS A 1 49  ? 27.71684 -9.49461  28.60554 1.000 21.75961  ? 46  CYS A O    1 
ATOM   694  C CB   . CYS A 1 49  ? 28.64875 -7.21075  26.13567 1.000 21.71986  ? 46  CYS A CB   1 
ATOM   695  S SG   . CYS A 1 49  ? 28.12858 -6.32361  24.64342 1.000 23.96348  ? 46  CYS A SG   1 
ATOM   696  H H    . CYS A 1 49  ? 26.39930 -7.21022  27.12918 1.000 28.00975  ? 46  CYS A H    1 
ATOM   697  H HA   . CYS A 1 49  ? 27.75851 -8.98558  25.65554 1.000 28.16911  ? 46  CYS A HA   1 
ATOM   698  H HB2  . CYS A 1 49  ? 28.60250 -6.59271  26.88185 1.000 26.08281  ? 46  CYS A HB2  1 
ATOM   699  H HB3  . CYS A 1 49  ? 29.56379 -7.50470  26.00459 1.000 26.08281  ? 46  CYS A HB3  1 
ATOM   700  H HG   . CYS A 1 49  ? 26.98436 -5.98462  24.76933 1.000 28.77516  ? 46  CYS A HG   1 
ATOM   701  N N    . SER A 1 50  ? 29.58990 -9.73514  27.38821 1.000 20.86324  ? 47  SER A N    1 
ATOM   702  C CA   . SER A 1 50  ? 30.14934 -10.78234 28.23764 1.000 22.00241  ? 47  SER A CA   1 
ATOM   703  C C    . SER A 1 50  ? 30.26957 -10.33050 29.68516 1.000 22.61214  ? 47  SER A C    1 
ATOM   704  O O    . SER A 1 50  ? 30.11499 -11.14068 30.60277 1.000 22.69484  ? 47  SER A O    1 
ATOM   705  C CB   . SER A 1 50  ? 31.52200 -11.21861 27.70830 1.000 22.08569  ? 47  SER A CB   1 
ATOM   706  O OG   . SER A 1 50  ? 32.48656 -10.16546 27.79818 1.000 20.75075  ? 47  SER A OG   1 
ATOM   707  H H    . SER A 1 50  ? 30.12491 -9.45919  26.77404 1.000 25.05487  ? 47  SER A H    1 
ATOM   708  H HA   . SER A 1 50  ? 29.55128 -11.54548 28.20857 1.000 26.42188  ? 47  SER A HA   1 
ATOM   709  H HB2  . SER A 1 50  ? 31.83349 -11.97230 28.23349 1.000 26.52181  ? 47  SER A HB2  1 
ATOM   710  H HB3  . SER A 1 50  ? 31.42939 -11.47800 26.77823 1.000 26.52181  ? 47  SER A HB3  1 
ATOM   711  H HG   . SER A 1 50  ? 32.24172 -9.51106  27.33191 1.000 24.91988  ? 47  SER A HG   1 
ATOM   712  N N    . ARG A 1 51  ? 30.59051 -9.05653  29.91742 1.000 20.44616  ? 48  ARG A N    1 
ATOM   713  C CA   . ARG A 1 51  ? 30.67038 -8.52550  31.27379 1.000 21.38526  ? 48  ARG A CA   1 
ATOM   714  C C    . ARG A 1 51  ? 29.45915 -7.66752  31.61961 1.000 22.86866  ? 48  ARG A C    1 
ATOM   715  O O    . ARG A 1 51  ? 29.57197 -6.70532  32.38784 1.000 21.56495  ? 48  ARG A O    1 
ATOM   716  C CB   . ARG A 1 51  ? 31.97174 -7.74786  31.47667 1.000 20.90337  ? 48  ARG A CB   1 
ATOM   717  C CG   . ARG A 1 51  ? 33.16357 -8.63028  31.86562 1.000 21.41903  ? 48  ARG A CG   1 
ATOM   718  C CD   . ARG A 1 51  ? 33.54585 -9.60305  30.75364 1.000 22.75369  ? 48  ARG A CD   1 
ATOM   719  N NE   . ARG A 1 51  ? 34.54313 -10.58170 31.16977 1.000 22.48841  ? 48  ARG A NE   1 
ATOM   720  C CZ   . ARG A 1 51  ? 35.03376 -11.52259 30.37530 1.000 22.95598  ? 48  ARG A CZ   1 
ATOM   721  N NH1  . ARG A 1 51  ? 34.67373 -11.60773 29.10657 1.000 22.15485  ? 48  ARG A NH1  1 
ATOM   722  N NH2  . ARG A 1 51  ? 35.91161 -12.39475 30.86376 1.000 25.37343  ? 48  ARG A NH2  1 
ATOM   723  H H    . ARG A 1 51  ? 30.76614 -8.48166  29.30237 1.000 24.55438  ? 48  ARG A H    1 
ATOM   724  H HA   . ARG A 1 51  ? 30.68759 -9.26977  31.89562 1.000 25.68130  ? 48  ARG A HA   1 
ATOM   725  H HB2  . ARG A 1 51  ? 32.19640 -7.29448  30.64909 1.000 25.10302  ? 48  ARG A HB2  1 
ATOM   726  H HB3  . ARG A 1 51  ? 31.83996 -7.09877  32.18534 1.000 25.10302  ? 48  ARG A HB3  1 
ATOM   727  H HG2  . ARG A 1 51  ? 33.93081 -8.06641  32.05080 1.000 25.72182  ? 48  ARG A HG2  1 
ATOM   728  H HG3  . ARG A 1 51  ? 32.93387 -9.14723  32.65359 1.000 25.72182  ? 48  ARG A HG3  1 
ATOM   729  H HD2  . ARG A 1 51  ? 32.75347 -10.08591 30.47102 1.000 27.32341  ? 48  ARG A HD2  1 
ATOM   730  H HD3  . ARG A 1 51  ? 33.91228 -9.10174  30.00844 1.000 27.32341  ? 48  ARG A HD3  1 
ATOM   731  H HE   . ARG A 1 51  ? 34.83045 -10.54644 31.97958 1.000 27.00508  ? 48  ARG A HE   1 
ATOM   732  H HH11 . ARG A 1 51  ? 34.11020 -11.04565 28.78085 1.000 26.60481  ? 48  ARG A HH11 1 
ATOM   733  H HH12 . ARG A 1 51  ? 35.00299 -12.22522 28.60666 1.000 26.60481  ? 48  ARG A HH12 1 
ATOM   734  H HH21 . ARG A 1 51  ? 36.15510 -12.34450 31.68703 1.000 30.46709  ? 48  ARG A HH21 1 
ATOM   735  H HH22 . ARG A 1 51  ? 36.23560 -13.00880 30.35623 1.000 30.46709  ? 48  ARG A HH22 1 
ATOM   736  N N    . ASP A 1 52  ? 28.30084 -7.99799  31.04632 1.000 21.49653  ? 49  ASP A N    1 
ATOM   737  C CA   . ASP A 1 52  ? 26.99430 -7.45735  31.40930 1.000 25.54572  ? 49  ASP A CA   1 
ATOM   738  C C    . ASP A 1 52  ? 26.80250 -6.00173  31.01485 1.000 24.23390  ? 49  ASP A C    1 
ATOM   739  O O    . ASP A 1 52  ? 25.81060 -5.38423  31.42413 1.000 24.67187  ? 49  ASP A O    1 
ATOM   740  C CB   . ASP A 1 52  ? 26.71991 -7.61723  32.91005 1.000 26.82427  ? 49  ASP A CB   1 
ATOM   741  C CG   . ASP A 1 52  ? 26.28081 -9.01599  33.27042 1.000 32.42038  ? 49  ASP A CG   1 
ATOM   742  O OD1  . ASP A 1 52  ? 25.85697 -9.75247  32.36128 1.000 31.68723  ? 49  ASP A OD1  1 
ATOM   743  O OD2  . ASP A 1 52  ? 26.34103 -9.37200  34.45932 1.000 35.32298  ? 49  ASP A OD2  1 
ATOM   744  H H    . ASP A 1 52  ? 28.24744 -8.56904  30.40550 1.000 25.81481  ? 49  ASP A H    1 
ATOM   745  H HA   . ASP A 1 52  ? 26.32858 -7.96376  30.91810 1.000 30.67385  ? 49  ASP A HA   1 
ATOM   746  H HB2  . ASP A 1 52  ? 27.53122 -7.41968  33.40367 1.000 32.20811  ? 49  ASP A HB2  1 
ATOM   747  H HB3  . ASP A 1 52  ? 26.01523 -7.00377  33.17081 1.000 32.20811  ? 49  ASP A HB3  1 
ATOM   748  N N    . VAL A 1 53  ? 27.69521 -5.44293  30.20373 1.000 21.62047  ? 50  VAL A N    1 
ATOM   749  C CA   . VAL A 1 53  ? 27.41891 -4.15906  29.58448 1.000 20.21739  ? 50  VAL A CA   1 
ATOM   750  C C    . VAL A 1 53  ? 26.38174 -4.38499  28.49605 1.000 23.34400  ? 50  VAL A C    1 
ATOM   751  O O    . VAL A 1 53  ? 26.50535 -5.31134  27.68036 1.000 21.28043  ? 50  VAL A O    1 
ATOM   752  C CB   . VAL A 1 53  ? 28.70577 -3.53374  29.02224 1.000 21.65847  ? 50  VAL A CB   1 
ATOM   753  C CG1  . VAL A 1 53  ? 28.38071 -2.25412  28.27978 1.000 22.23365  ? 50  VAL A CG1  1 
ATOM   754  C CG2  . VAL A 1 53  ? 29.70877 -3.27476  30.12850 1.000 24.82691  ? 50  VAL A CG2  1 
ATOM   755  H H    . VAL A 1 53  ? 28.45769 -5.78471  30.00024 1.000 25.96354  ? 50  VAL A H    1 
ATOM   756  H HA   . VAL A 1 53  ? 27.06477 -3.54079  30.24268 1.000 24.27985  ? 50  VAL A HA   1 
ATOM   757  H HB   . VAL A 1 53  ? 29.11174 -4.15570  28.39833 1.000 26.00915  ? 50  VAL A HB   1 
ATOM   758  H HG11 . VAL A 1 53  ? 29.20084 -1.75769  28.13203 1.000 26.69937  ? 50  VAL A HG11 1 
ATOM   759  H HG12 . VAL A 1 53  ? 27.97161 -2.47776  27.42918 1.000 26.69937  ? 50  VAL A HG12 1 
ATOM   760  H HG13 . VAL A 1 53  ? 27.76634 -1.72655  28.81376 1.000 26.69937  ? 50  VAL A HG13 1 
ATOM   761  H HG21 . VAL A 1 53  ? 30.50572 -2.87614  29.74526 1.000 29.81127  ? 50  VAL A HG21 1 
ATOM   762  H HG22 . VAL A 1 53  ? 29.31509 -2.66970  30.77642 1.000 29.81127  ? 50  VAL A HG22 1 
ATOM   763  H HG23 . VAL A 1 53  ? 29.93250 -4.11657  30.55536 1.000 29.81127  ? 50  VAL A HG23 1 
ATOM   764  N N    . VAL A 1 54  ? 25.34504 -3.55417  28.48414 1.000 22.04642  ? 51  VAL A N    1 
ATOM   765  C CA   . VAL A 1 54  ? 24.23642 -3.70160  27.54584 1.000 23.39516  ? 51  VAL A CA   1 
ATOM   766  C C    . VAL A 1 54  ? 24.30526 -2.58434  26.51013 1.000 23.66766  ? 51  VAL A C    1 
ATOM   767  O O    . VAL A 1 54  ? 24.20176 -1.39819  26.84842 1.000 22.85594  ? 51  VAL A O    1 
ATOM   768  C CB   . VAL A 1 54  ? 22.88254 -3.69556  28.26894 1.000 26.08832  ? 51  VAL A CB   1 
ATOM   769  C CG1  . VAL A 1 54  ? 21.73640 -3.78749  27.25909 1.000 26.12204  ? 51  VAL A CG1  1 
ATOM   770  C CG2  . VAL A 1 54  ? 22.81285 -4.82991  29.27712 1.000 25.49870  ? 51  VAL A CG2  1 
ATOM   771  H H    . VAL A 1 54  ? 25.25970 -2.88612  29.01895 1.000 26.47468  ? 51  VAL A H    1 
ATOM   772  H HA   . VAL A 1 54  ? 24.33991 -4.54404  27.07628 1.000 28.09317  ? 51  VAL A HA   1 
ATOM   773  H HB   . VAL A 1 54  ? 22.78651 -2.86078  28.75352 1.000 31.32497  ? 51  VAL A HB   1 
ATOM   774  H HG11 . VAL A 1 54  ? 20.92334 -4.03622  27.72597 1.000 31.36543  ? 51  VAL A HG11 1 
ATOM   775  H HG12 . VAL A 1 54  ? 21.62171 -2.92412  26.83209 1.000 31.36543  ? 51  VAL A HG12 1 
ATOM   776  H HG13 . VAL A 1 54  ? 21.95457 -4.45906  26.59404 1.000 31.36543  ? 51  VAL A HG13 1 
ATOM   777  H HG21 . VAL A 1 54  ? 21.93708 -4.82840  29.69416 1.000 30.61742  ? 51  VAL A HG21 1 
ATOM   778  H HG22 . VAL A 1 54  ? 22.95846 -5.67111  28.81659 1.000 30.61742  ? 51  VAL A HG22 1 
ATOM   779  H HG23 . VAL A 1 54  ? 23.49955 -4.69762  29.94931 1.000 30.61742  ? 51  VAL A HG23 1 
ATOM   780  N N    . ILE A 1 55  ? 24.46629 -2.96415  25.24628 1.000 21.77766  ? 52  ILE A N    1 
ATOM   781  C CA   . ILE A 1 55  ? 24.63928 -2.02261  24.14738 1.000 22.76588  ? 52  ILE A CA   1 
ATOM   782  C C    . ILE A 1 55  ? 23.43581 -2.12623  23.22264 1.000 26.27622  ? 52  ILE A C    1 
ATOM   783  O O    . ILE A 1 55  ? 22.99477 -3.23015  22.88800 1.000 24.45260  ? 52  ILE A O    1 
ATOM   784  C CB   . ILE A 1 55  ? 25.95045 -2.30683  23.38744 1.000 26.49967  ? 52  ILE A CB   1 
ATOM   785  C CG1  . ILE A 1 55  ? 27.14427 -1.99089  24.28806 1.000 27.31616  ? 52  ILE A CG1  1 
ATOM   786  C CG2  . ILE A 1 55  ? 26.00034 -1.52883  22.08960 1.000 26.83547  ? 52  ILE A CG2  1 
ATOM   787  C CD1  . ILE A 1 55  ? 28.46526 -2.46590  23.73675 1.000 31.23765  ? 52  ILE A CD1  1 
ATOM   788  H H    . ILE A 1 55  ? 24.47900 -3.78639  24.99454 1.000 26.15218  ? 52  ILE A H    1 
ATOM   789  H HA   . ILE A 1 55  ? 24.67230 -1.11715  24.49371 1.000 27.33803  ? 52  ILE A HA   1 
ATOM   790  H HB   . ILE A 1 55  ? 25.98605 -3.24812  23.15590 1.000 31.81858  ? 52  ILE A HB   1 
ATOM   791  H HG12 . ILE A 1 55  ? 27.20088 -1.02960  24.40478 1.000 32.79837  ? 52  ILE A HG12 1 
ATOM   792  H HG13 . ILE A 1 55  ? 27.00978 -2.42196  25.14654 1.000 32.79837  ? 52  ILE A HG13 1 
ATOM   793  H HG21 . ILE A 1 55  ? 26.91572 -1.50707  21.76943 1.000 32.22154  ? 52  ILE A HG21 1 
ATOM   794  H HG22 . ILE A 1 55  ? 25.43193 -1.96671  21.43686 1.000 32.22154  ? 52  ILE A HG22 1 
ATOM   795  H HG23 . ILE A 1 55  ? 25.68459 -0.62586  22.25036 1.000 32.22154  ? 52  ILE A HG23 1 
ATOM   796  H HD11 . ILE A 1 55  ? 29.14727 -2.36363  24.41888 1.000 37.50416  ? 52  ILE A HD11 1 
ATOM   797  H HD12 . ILE A 1 55  ? 28.38548 -3.39956  23.48612 1.000 37.50416  ? 52  ILE A HD12 1 
ATOM   798  H HD13 . ILE A 1 55  ? 28.69284 -1.93290  22.95892 1.000 37.50416  ? 52  ILE A HD13 1 
ATOM   799  N N    . CYS A 1 56  ? 22.91890 -0.97672  22.79715 1.000 22.67877  ? 53  CYS A N    1 
ATOM   800  C CA   . CYS A 1 56  ? 21.81739 -0.92867  21.84602 1.000 23.61368  ? 53  CYS A CA   1 
ATOM   801  C C    . CYS A 1 56  ? 22.36901 -0.87086  20.43286 1.000 25.03341  ? 53  CYS A C    1 
ATOM   802  O O    . CYS A 1 56  ? 23.07602 0.09312   20.09413 1.000 25.39250  ? 53  CYS A O    1 
ATOM   803  C CB   . CYS A 1 56  ? 20.93998 0.28703   22.10186 1.000 25.46123  ? 53  CYS A CB   1 
ATOM   804  S SG   . CYS A 1 56  ? 20.14517 0.27461   23.68858 1.000 35.94489  ? 53  CYS A SG   1 
ATOM   805  H H    . CYS A 1 56  ? 23.19335 -0.20148  23.04869 1.000 27.23350  ? 53  CYS A H    1 
ATOM   806  H HA   . CYS A 1 56  ? 21.27439 -1.72732  21.93662 1.000 28.35540  ? 53  CYS A HA   1 
ATOM   807  H HB2  . CYS A 1 56  ? 21.49015 1.08438   22.05245 1.000 30.57246  ? 53  CYS A HB2  1 
ATOM   808  H HB3  . CYS A 1 56  ? 20.24709 0.31951   21.42380 1.000 30.57246  ? 53  CYS A HB3  1 
ATOM   809  H HG   . CYS A 1 56  ? 19.45506 1.25132   23.78752 1.000 43.15285  ? 53  CYS A HG   1 
ATOM   810  N N    . PRO A 1 57  ? 22.07798 -1.84839  19.58309 1.000 25.44784  ? 54  PRO A N    1 
ATOM   811  C CA   A PRO A 1 57  ? 22.59292 -1.79624  18.21157 0.621 24.94705  ? 54  PRO A CA   1 
ATOM   812  C CA   B PRO A 1 57  ? 22.58935 -1.79829  18.20992 0.379 24.98913  ? 54  PRO A CA   1 
ATOM   813  C C    . PRO A 1 57  ? 21.89819 -0.71961  17.39197 1.000 25.12310  ? 54  PRO A C    1 
ATOM   814  O O    . PRO A 1 57  ? 20.80468 -0.24989  17.71113 1.000 25.22977  ? 54  PRO A O    1 
ATOM   815  C CB   A PRO A 1 57  ? 22.29998 -3.19462  17.65865 0.621 25.50904  ? 54  PRO A CB   1 
ATOM   816  C CB   B PRO A 1 57  ? 22.28346 -3.19274  17.64926 0.379 25.40709  ? 54  PRO A CB   1 
ATOM   817  C CG   A PRO A 1 57  ? 21.11970 -3.67062  18.44901 0.621 26.44100  ? 54  PRO A CG   1 
ATOM   818  C CG   B PRO A 1 57  ? 22.02519 -4.06355  18.85266 0.379 25.86712  ? 54  PRO A CG   1 
ATOM   819  C CD   A PRO A 1 57  ? 21.27006 -3.05932  19.84168 0.621 25.58231  ? 54  PRO A CD   1 
ATOM   820  C CD   B PRO A 1 57  ? 21.42249 -3.13493  19.89161 0.379 25.95466  ? 54  PRO A CD   1 
ATOM   821  H HA   A PRO A 1 57  ? 23.55050 -1.64153  18.20966 0.621 29.95544  ? 54  PRO A HA   1 
ATOM   822  H HA   B PRO A 1 57  ? 23.54800 -1.65033  18.21059 0.379 30.00594  ? 54  PRO A HA   1 
ATOM   823  H HB2  A PRO A 1 57  ? 22.08825 -3.14052  16.71359 0.621 30.62982  ? 54  PRO A HB2  1 
ATOM   824  H HB2  B PRO A 1 57  ? 21.50053 -3.15213  17.07806 0.379 30.50749  ? 54  PRO A HB2  1 
ATOM   825  H HB3  A PRO A 1 57  ? 23.06691 -3.77283  17.79425 0.621 30.62982  ? 54  PRO A HB3  1 
ATOM   826  H HB3  B PRO A 1 57  ? 23.04556 -3.51795  17.14494 0.379 30.50749  ? 54  PRO A HB3  1 
ATOM   827  H HG2  A PRO A 1 57  ? 20.30060 -3.36654  18.02768 0.621 31.74818  ? 54  PRO A HG2  1 
ATOM   828  H HG2  B PRO A 1 57  ? 21.40491 -4.77220  18.62032 0.379 31.05953  ? 54  PRO A HG2  1 
ATOM   829  H HG3  A PRO A 1 57  ? 21.12823 -4.63939  18.49703 0.621 31.74818  ? 54  PRO A HG3  1 
ATOM   830  H HG3  B PRO A 1 57  ? 22.85922 -4.44359  19.17025 0.379 31.05953  ? 54  PRO A HG3  1 
ATOM   831  H HD2  A PRO A 1 57  ? 20.40502 -2.82643  20.21366 0.621 30.71775  ? 54  PRO A HD2  1 
ATOM   832  H HD2  B PRO A 1 57  ? 20.46044 -3.07052  19.78573 0.379 31.16457  ? 54  PRO A HD2  1 
ATOM   833  H HD3  A PRO A 1 57  ? 21.73541 -3.66602  20.43856 0.621 30.71775  ? 54  PRO A HD3  1 
ATOM   834  H HD3  B PRO A 1 57  ? 21.63835 -3.42979  20.79015 0.379 31.16457  ? 54  PRO A HD3  1 
ATOM   835  N N    . ASP A 1 58  ? 22.57113 -0.32107  16.31873 1.000 25.07858  ? 55  ASP A N    1 
ATOM   836  C CA   . ASP A 1 58  ? 22.00338 0.67087   15.41363 1.000 25.10433  ? 55  ASP A CA   1 
ATOM   837  C C    . ASP A 1 58  ? 20.90429 0.06439   14.55164 1.000 30.85626  ? 55  ASP A C    1 
ATOM   838  O O    . ASP A 1 58  ? 19.97636 0.76405   14.13971 1.000 32.97212  ? 55  ASP A O    1 
ATOM   839  C CB   . ASP A 1 58  ? 23.09159 1.25777   14.51297 1.000 25.25580  ? 55  ASP A CB   1 
ATOM   840  C CG   . ASP A 1 58  ? 24.17021 1.97611   15.28236 1.000 25.23359  ? 55  ASP A CG   1 
ATOM   841  O OD1  . ASP A 1 58  ? 23.84671 2.68737   16.25175 1.000 26.26969  ? 55  ASP A OD1  1 
ATOM   842  O OD2  . ASP A 1 58  ? 25.34713 1.82797   14.90194 1.000 27.20244  ? 55  ASP A OD2  1 
ATOM   843  H H    . ASP A 1 58  ? 23.35061 -0.60580  16.09302 1.000 30.11328  ? 55  ASP A H    1 
ATOM   844  H HA   . ASP A 1 58  ? 21.62785 1.39125   15.94367 1.000 30.14417  ? 55  ASP A HA   1 
ATOM   845  H HB2  . ASP A 1 58  ? 23.50924 0.53847   14.01390 1.000 30.32594  ? 55  ASP A HB2  1 
ATOM   846  H HB3  . ASP A 1 58  ? 22.68633 1.89339   13.90252 1.000 30.32594  ? 55  ASP A HB3  1 
ATOM   847  N N    . ALA A 1 59  ? 20.99732 -1.22729  14.26580 1.000 26.85410  ? 56  ALA A N    1 
ATOM   848  C CA   . ALA A 1 59  ? 20.05632 -1.90633  13.39043 1.000 32.21620  ? 56  ALA A CA   1 
ATOM   849  C C    . ALA A 1 59  ? 20.15643 -3.40426  13.64376 1.000 30.88467  ? 56  ALA A C    1 
ATOM   850  O O    . ALA A 1 59  ? 21.10635 -3.88890  14.26229 1.000 27.69945  ? 56  ALA A O    1 
ATOM   851  C CB   . ALA A 1 59  ? 20.34350 -1.58742  11.92292 1.000 30.80506  ? 56  ALA A CB   1 
ATOM   852  H H    A ALA A 1 59  ? 21.61171 -1.74402  14.57423 0.670 32.24390  ? 56  ALA A H    1 
ATOM   853  H H    B ALA A 1 59  ? 21.61171 -1.74402  14.57423 0.330 32.24390  ? 56  ALA A H    1 
ATOM   854  H HA   . ALA A 1 59  ? 19.15480 -1.61772  13.60225 1.000 38.67842  ? 56  ALA A HA   1 
ATOM   855  H HB1  . ALA A 1 59  ? 19.69063 -2.04143  11.36746 1.000 36.98506  ? 56  ALA A HB1  1 
ATOM   856  H HB2  . ALA A 1 59  ? 20.28120 -0.62858  11.79006 1.000 36.98506  ? 56  ALA A HB2  1 
ATOM   857  H HB3  . ALA A 1 59  ? 21.23663 -1.89464  11.70191 1.000 36.98506  ? 56  ALA A HB3  1 
ATOM   858  N N    . SER A 1 60  ? 19.16411 -4.13388  13.14877 1.000 31.46816  ? 57  SER A N    1 
ATOM   859  C CA   . SER A 1 60  ? 19.27294 -5.58124  13.07523 1.000 30.80240  ? 57  SER A CA   1 
ATOM   860  C C    . SER A 1 60  ? 20.21638 -5.96199  11.93564 1.000 29.74901  ? 57  SER A C    1 
ATOM   861  O O    . SER A 1 60  ? 20.41979 -5.20665  10.97558 1.000 29.59481  ? 57  SER A O    1 
ATOM   862  C CB   . SER A 1 60  ? 17.90026 -6.22613  12.85109 1.000 34.80132  ? 57  SER A CB   1 
ATOM   863  O OG   . SER A 1 60  ? 17.48106 -6.01580  11.51419 1.000 36.16904  ? 57  SER A OG   1 
ATOM   864  H H    . SER A 1 60  ? 18.42257 -3.81589  12.85111 1.000 37.78077  ? 57  SER A H    1 
ATOM   865  H HA   . SER A 1 60  ? 19.62346 -5.92606  13.91137 1.000 36.98186  ? 57  SER A HA   1 
ATOM   866  H HB2  . SER A 1 60  ? 17.96363 -7.17923  13.01986 1.000 41.78057  ? 57  SER A HB2  1 
ATOM   867  H HB3  . SER A 1 60  ? 17.25609 -5.82440  13.45487 1.000 41.78057  ? 57  SER A HB3  1 
ATOM   868  H HG   . SER A 1 60  ? 16.73043 -6.37150  11.38914 1.000 43.42183  ? 57  SER A HG   1 
ATOM   869  N N    . LEU A 1 61  ? 20.81728 -7.14686  12.05867 1.000 27.90544  ? 58  LEU A N    1 
ATOM   870  C CA   . LEU A 1 61  ? 21.67243 -7.63577  10.98358 1.000 30.23771  ? 58  LEU A CA   1 
ATOM   871  C C    . LEU A 1 61  ? 20.86665 -7.81174  9.69710  1.000 33.10000  ? 58  LEU A C    1 
ATOM   872  O O    . LEU A 1 61  ? 21.36025 -7.53878  8.59471  1.000 32.96944  ? 58  LEU A O    1 
ATOM   873  C CB   . LEU A 1 61  ? 22.33297 -8.95168  11.39806 1.000 30.82795  ? 58  LEU A CB   1 
ATOM   874  C CG   . LEU A 1 61  ? 23.35472 -9.50992  10.40179 1.000 28.50557  ? 58  LEU A CG   1 
ATOM   875  C CD1  . LEU A 1 61  ? 24.45600 -8.49854  10.13132 1.000 31.85167  ? 58  LEU A CD1  1 
ATOM   876  C CD2  . LEU A 1 61  ? 23.93561 -10.82047 10.92705 1.000 32.85451  ? 58  LEU A CD2  1 
ATOM   877  H H    . LEU A 1 61  ? 20.74709 -7.67141  12.73656 1.000 33.50551  ? 58  LEU A H    1 
ATOM   878  H HA   . LEU A 1 61  ? 22.37907 -6.99304  10.81490 1.000 36.30423  ? 58  LEU A HA   1 
ATOM   879  H HB2  . LEU A 1 61  ? 22.79448 -8.81034  12.23944 1.000 37.01253  ? 58  LEU A HB2  1 
ATOM   880  H HB3  . LEU A 1 61  ? 21.63914 -9.62049  11.50851 1.000 37.01253  ? 58  LEU A HB3  1 
ATOM   881  H HG   . LEU A 1 61  ? 22.91188 -9.68966  9.55770  1.000 34.22567  ? 58  LEU A HG   1 
ATOM   882  H HD11 . LEU A 1 61  ? 25.23553 -8.96415  9.79009  1.000 38.24098  ? 58  LEU A HD11 1 
ATOM   883  H HD12 . LEU A 1 61  ? 24.14109 -7.85642  9.47602  1.000 38.24098  ? 58  LEU A HD12 1 
ATOM   884  H HD13 . LEU A 1 61  ? 24.67803 -8.04444  10.95920 1.000 38.24098  ? 58  LEU A HD13 1 
ATOM   885  H HD21 . LEU A 1 61  ? 24.55343 -11.17780 10.27016 1.000 39.44439  ? 58  LEU A HD21 1 
ATOM   886  H HD22 . LEU A 1 61  ? 24.40174 -10.64790 11.76002 1.000 39.44439  ? 58  LEU A HD22 1 
ATOM   887  H HD23 . LEU A 1 61  ? 23.21212 -11.44897 11.07693 1.000 39.44439  ? 58  LEU A HD23 1 
ATOM   888  N N    . GLU A 1 62  ? 19.61345 -8.25784  9.82136  1.000 37.00200  ? 59  GLU A N    1 
ATOM   889  C CA   . GLU A 1 62  ? 18.77251 -8.44246  8.64408  1.000 41.70359  ? 59  GLU A CA   1 
ATOM   890  C C    . GLU A 1 62  ? 18.61013 -7.13760  7.87713  1.000 38.05278  ? 59  GLU A C    1 
ATOM   891  O O    . GLU A 1 62  ? 18.71160 -7.11664  6.64766  1.000 42.18611  ? 59  GLU A O    1 
ATOM   892  C CB   . GLU A 1 62  ? 17.41458 -8.99262  9.06616  1.000 52.43338  ? 59  GLU A CB   1 
ATOM   893  C CG   . GLU A 1 62  ? 16.57195 -9.51381  7.91996  1.000 84.38047  ? 59  GLU A CG   1 
ATOM   894  C CD   . GLU A 1 62  ? 15.16654 -9.87876  8.35705  1.000 106.81720 ? 59  GLU A CD   1 
ATOM   895  O OE1  . GLU A 1 62  ? 14.88801 -9.83353  9.57647  1.000 91.27657  ? 59  GLU A OE1  1 
ATOM   896  O OE2  . GLU A 1 62  ? 14.33952 -10.20299 7.47888  1.000 118.44803 ? 59  GLU A OE2  1 
ATOM   897  H H    . GLU A 1 62  ? 19.23370 -8.45743  10.56671 1.000 44.42138  ? 59  GLU A H    1 
ATOM   898  H HA   . GLU A 1 62  ? 19.18952 -9.08678  8.05091  1.000 50.06329  ? 59  GLU A HA   1 
ATOM   899  H HB2  . GLU A 1 62  ? 17.55596 -9.72629  9.68474  1.000 62.93903  ? 59  GLU A HB2  1 
ATOM   900  H HB3  . GLU A 1 62  ? 16.91442 -8.28409  9.50059  1.000 62.93903  ? 59  GLU A HB3  1 
ATOM   901  H HG2  . GLU A 1 62  ? 16.50695 -8.82874  7.23633  1.000 101.27555 ? 59  GLU A HG2  1 
ATOM   902  H HG3  . GLU A 1 62  ? 16.99015 -10.30891 7.55415  1.000 101.27555 ? 59  GLU A HG3  1 
ATOM   903  N N    . ASP A 1 63  ? 18.39222 -6.03057  8.58776  1.000 36.60767  ? 60  ASP A N    1 
ATOM   904  C CA   . ASP A 1 63  ? 18.24380 -4.74507  7.91479  1.000 38.65621  ? 60  ASP A CA   1 
ATOM   905  C C    . ASP A 1 63  ? 19.58319 -4.23600  7.40169  1.000 40.07779  ? 60  ASP A C    1 
ATOM   906  O O    . ASP A 1 63  ? 19.66668 -3.70673  6.28851  1.000 39.91808  ? 60  ASP A O    1 
ATOM   907  C CB   . ASP A 1 63  ? 17.61076 -3.72231  8.85996  1.000 41.79033  ? 60  ASP A CB   1 
ATOM   908  C CG   . ASP A 1 63  ? 16.12392 -3.97150  9.08156  1.000 45.47564  ? 60  ASP A CG   1 
ATOM   909  O OD1  . ASP A 1 63  ? 15.53766 -4.79081  8.34719  1.000 51.50666  ? 60  ASP A OD1  1 
ATOM   910  O OD2  . ASP A 1 63  ? 15.54251 -3.34730  9.98568  1.000 53.11039  ? 60  ASP A OD2  1 
ATOM   911  H H    A ASP A 1 63  ? 18.32749 -5.99843  9.44472  0.610 43.94819  ? 60  ASP A H    1 
ATOM   912  H H    B ASP A 1 63  ? 18.32749 -5.99843  9.44472  0.390 43.94819  ? 60  ASP A H    1 
ATOM   913  H HA   . ASP A 1 63  ? 17.65037 -4.85870  7.15595  1.000 46.40644  ? 60  ASP A HA   1 
ATOM   914  H HB2  . ASP A 1 63  ? 18.05503 -3.76932  9.72095  1.000 50.16738  ? 60  ASP A HB2  1 
ATOM   915  H HB3  . ASP A 1 63  ? 17.71373 -2.83514  8.48150  1.000 50.16738  ? 60  ASP A HB3  1 
ATOM   916  N N    . ALA A 1 64  ? 20.64262 -4.37862  8.19836  1.000 35.97443  ? 61  ALA A N    1 
ATOM   917  C CA   . ALA A 1 64  ? 21.94402 -3.88943  7.76166  1.000 35.73855  ? 61  ALA A CA   1 
ATOM   918  C C    . ALA A 1 64  ? 22.44975 -4.66139  6.54902  1.000 35.34823  ? 61  ALA A C    1 
ATOM   919  O O    . ALA A 1 64  ? 23.17831 -4.10692  5.71899  1.000 37.68515  ? 61  ALA A O    1 
ATOM   920  C CB   . ALA A 1 64  ? 22.94902 -3.97850  8.91161  1.000 36.83694  ? 61  ALA A CB   1 
ATOM   921  H H    . ALA A 1 64  ? 20.63316 -4.74573  8.97601  1.000 43.18829  ? 61  ALA A H    1 
ATOM   922  H HA   . ALA A 1 64  ? 21.86284 -2.95624  7.50976  1.000 42.90524  ? 61  ALA A HA   1 
ATOM   923  H HB1  . ALA A 1 64  ? 23.80773 -3.64571  8.60703  1.000 44.22331  ? 61  ALA A HB1  1 
ATOM   924  H HB2  . ALA A 1 64  ? 22.62957 -3.44019  9.65260  1.000 44.22331  ? 61  ALA A HB2  1 
ATOM   925  H HB3  . ALA A 1 64  ? 23.03214 -4.90476  9.18734  1.000 44.22331  ? 61  ALA A HB3  1 
ATOM   926  N N    . LYS A 1 65  ? 22.09754 -5.94304  6.44770  1.000 37.36412  ? 62  LYS A N    1 
ATOM   927  C CA   . LYS A 1 65  ? 22.50418 -6.74902  5.30130  1.000 43.03556  ? 62  LYS A CA   1 
ATOM   928  C C    . LYS A 1 65  ? 22.05797 -6.10673  3.99525  1.000 46.75474  ? 62  LYS A C    1 
ATOM   929  O O    . LYS A 1 65  ? 22.76589 -6.18103  2.98589  1.000 51.68113  ? 62  LYS A O    1 
ATOM   930  C CB   . LYS A 1 65  ? 21.92047 -8.15877  5.43833  1.000 49.14078  ? 62  LYS A CB   1 
ATOM   931  C CG   . LYS A 1 65  ? 22.26811 -9.12328  4.32098  1.000 72.36752  ? 62  LYS A CG   1 
ATOM   932  C CD   . LYS A 1 65  ? 21.25511 -10.27944 4.24373  1.000 102.52011 ? 62  LYS A CD   1 
ATOM   933  C CE   . LYS A 1 65  ? 21.21856 -11.10973 5.52641  1.000 81.67843  ? 62  LYS A CE   1 
ATOM   934  N NZ   . LYS A 1 65  ? 22.46072 -11.92459 5.70381  1.000 86.19104  ? 62  LYS A NZ   1 
ATOM   935  H H    . LYS A 1 65  ? 21.62506 -6.36783  7.02729  1.000 44.85593  ? 62  LYS A H    1 
ATOM   936  H HA   . LYS A 1 65  ? 23.47149 -6.81882  5.28294  1.000 51.66165  ? 62  LYS A HA   1 
ATOM   937  H HB2  . LYS A 1 65  ? 22.24858 -8.54529  6.26528  1.000 58.98792  ? 62  LYS A HB2  1 
ATOM   938  H HB3  . LYS A 1 65  ? 20.95356 -8.08672  5.46651  1.000 58.98792  ? 62  LYS A HB3  1 
ATOM   939  H HG2  . LYS A 1 65  ? 22.25827 -8.65131  3.47360  1.000 86.86001  ? 62  LYS A HG2  1 
ATOM   940  H HG3  . LYS A 1 65  ? 23.14813 -9.49834  4.48163  1.000 86.86001  ? 62  LYS A HG3  1 
ATOM   941  H HD2  . LYS A 1 65  ? 20.36828 -9.91547  4.09555  1.000 123.04311 ? 62  LYS A HD2  1 
ATOM   942  H HD3  . LYS A 1 65  ? 21.49906 -10.86724 3.51169  1.000 123.04311 ? 62  LYS A HD3  1 
ATOM   943  H HE2  . LYS A 1 65  ? 21.13482 -10.51569 6.28865  1.000 98.03309  ? 62  LYS A HE2  1 
ATOM   944  H HE3  . LYS A 1 65  ? 20.46153 -11.71527 5.49297  1.000 98.03309  ? 62  LYS A HE3  1 
ATOM   945  H HZ1  . LYS A 1 65  ? 22.41319 -12.39128 6.46015  1.000 103.44823 ? 62  LYS A HZ1  1 
ATOM   946  H HZ2  . LYS A 1 65  ? 22.55474 -12.48863 5.02181  1.000 103.44823 ? 62  LYS A HZ2  1 
ATOM   947  H HZ3  . LYS A 1 65  ? 23.17239 -11.39124 5.73775  1.000 103.44823 ? 62  LYS A HZ3  1 
ATOM   948  N N    . LYS A 1 66  ? 20.89344 -5.45628  3.99994  1.000 46.74808  ? 63  LYS A N    1 
ATOM   949  C CA   . LYS A 1 66  ? 20.34165 -4.88271  2.78009  1.000 57.92807  ? 63  LYS A CA   1 
ATOM   950  C C    . LYS A 1 66  ? 21.00010 -3.56701  2.39319  1.000 53.87757  ? 63  LYS A C    1 
ATOM   951  O O    . LYS A 1 66  ? 20.86454 -3.13936  1.24363  1.000 58.08693  ? 63  LYS A O    1 
ATOM   952  C CB   . LYS A 1 66  ? 18.83323 -4.66057  2.93800  1.000 54.62227  ? 63  LYS A CB   1 
ATOM   953  C CG   . LYS A 1 66  ? 18.05084 -5.91023  3.31621  1.000 61.05333  ? 63  LYS A CG   1 
ATOM   954  C CD   . LYS A 1 66  ? 16.61066 -5.56150  3.69695  1.000 75.27898  ? 63  LYS A CD   1 
ATOM   955  C CE   . LYS A 1 66  ? 15.84220 -6.79855  4.14532  1.000 90.60948  ? 63  LYS A CE   1 
ATOM   956  N NZ   . LYS A 1 66  ? 15.74795 -7.81693  3.06154  1.000 102.29643 ? 63  LYS A NZ   1 
ATOM   957  H H    . LYS A 1 66  ? 20.40587 -5.33510  4.69792  1.000 56.11667  ? 63  LYS A H    1 
ATOM   958  H HA   . LYS A 1 66  ? 20.48399 -5.51301  2.05664  1.000 69.53266  ? 63  LYS A HA   1 
ATOM   959  H HB2  . LYS A 1 66  ? 18.68877 -4.00160  3.63498  1.000 65.56570  ? 63  LYS A HB2  1 
ATOM   960  H HB3  . LYS A 1 66  ? 18.47842 -4.33578  2.09567  1.000 65.56570  ? 63  LYS A HB3  1 
ATOM   961  H HG2  . LYS A 1 66  ? 18.02989 -6.51916  2.56145  1.000 73.28298  ? 63  LYS A HG2  1 
ATOM   962  H HG3  . LYS A 1 66  ? 18.47413 -6.33874  4.07654  1.000 73.28298  ? 63  LYS A HG3  1 
ATOM   963  H HD2  . LYS A 1 66  ? 16.61608 -4.92343  4.42752  1.000 90.35376  ? 63  LYS A HD2  1 
ATOM   964  H HD3  . LYS A 1 66  ? 16.15714 -5.18177  2.92817  1.000 90.35376  ? 63  LYS A HD3  1 
ATOM   965  H HE2  . LYS A 1 66  ? 16.29756 -7.20119  4.90125  1.000 108.75036 ? 63  LYS A HE2  1 
ATOM   966  H HE3  . LYS A 1 66  ? 14.94202 -6.54118  4.39895  1.000 108.75036 ? 63  LYS A HE3  1 
ATOM   967  H HZ1  . LYS A 1 66  ? 15.27967 -8.51923  3.34366  1.000 122.77469 ? 63  LYS A HZ1  1 
ATOM   968  H HZ2  . LYS A 1 66  ? 15.34389 -7.46742  2.34973  1.000 122.77469 ? 63  LYS A HZ2  1 
ATOM   969  H HZ3  . LYS A 1 66  ? 16.56252 -8.08822  2.82709  1.000 122.77469 ? 63  LYS A HZ3  1 
ATOM   970  N N    . GLU A 1 67  ? 21.69782 -2.91134  3.31773  1.000 49.89450  ? 64  GLU A N    1 
ATOM   971  C CA   . GLU A 1 67  ? 22.31799 -1.62048  3.05514  1.000 48.58167  ? 64  GLU A CA   1 
ATOM   972  C C    . GLU A 1 67  ? 23.80030 -1.74368  2.71994  1.000 49.96992  ? 64  GLU A C    1 
ATOM   973  O O    . GLU A 1 67  ? 24.53530 -0.75371  2.80215  1.000 50.89647  ? 64  GLU A O    1 
ATOM   974  C CB   . GLU A 1 67  ? 22.12524 -0.69219  4.25342  1.000 55.46753  ? 64  GLU A CB   1 
ATOM   975  C CG   . GLU A 1 67  ? 20.66376 -0.44052  4.60592  1.000 76.77498  ? 64  GLU A CG   1 
ATOM   976  C CD   . GLU A 1 67  ? 20.48776 0.65903   5.63517  1.000 94.15020  ? 64  GLU A CD   1 
ATOM   977  O OE1  . GLU A 1 67  ? 21.05633 0.54506   6.74438  1.000 102.56640 ? 64  GLU A OE1  1 
ATOM   978  O OE2  . GLU A 1 67  ? 19.78780 1.64710   5.32495  1.000 91.68218  ? 64  GLU A OE2  1 
ATOM   979  H H    A GLU A 1 67  ? 21.82661 -3.20092  4.11720  0.591 59.89238  ? 64  GLU A H    1 
ATOM   980  H H    B GLU A 1 67  ? 21.82661 -3.20092  4.11720  0.409 59.89238  ? 64  GLU A H    1 
ATOM   981  H HA   . GLU A 1 67  ? 21.87581 -1.21995  2.29032  1.000 58.31699  ? 64  GLU A HA   1 
ATOM   982  H HB2  . GLU A 1 67  ? 22.55250 -1.09007  5.02804  1.000 66.58001  ? 64  GLU A HB2  1 
ATOM   983  H HB3  . GLU A 1 67  ? 22.53338 0.16463   4.05296  1.000 66.58001  ? 64  GLU A HB3  1 
ATOM   984  H HG2  . GLU A 1 67  ? 20.18583 -0.17900  3.80337  1.000 92.14896  ? 64  GLU A HG2  1 
ATOM   985  H HG3  . GLU A 1 67  ? 20.28173 -1.25482  4.96906  1.000 92.14896  ? 64  GLU A HG3  1 
ATOM   986  N N    . GLY A 1 68  ? 24.25168 -2.93157  2.33211  1.000 49.25518  ? 65  GLY A N    1 
ATOM   987  C CA   . GLY A 1 68  ? 25.62320 -3.12576  1.92692  1.000 50.76511  ? 65  GLY A CA   1 
ATOM   988  C C    . GLY A 1 68  ? 25.91429 -2.50428  0.57852  1.000 56.04614  ? 65  GLY A C    1 
ATOM   989  O O    . GLY A 1 68  ? 25.07163 -1.81665  -0.00340 1.000 60.86898  ? 65  GLY A O    1 
ATOM   990  H H    . GLY A 1 68  ? 23.77185 -3.64440  2.29709  1.000 59.12520  ? 65  GLY A H    1 
ATOM   991  H HA2  . GLY A 1 68  ? 26.21286 -2.72327  2.58358  1.000 60.93712  ? 65  GLY A HA2  1 
ATOM   992  H HA3  . GLY A 1 68  ? 25.81160 -4.07580  1.87357  1.000 60.93712  ? 65  GLY A HA3  1 
ATOM   993  N N    . PRO A 1 69  ? 27.12712 -2.73061  0.05019  1.000 58.70033  ? 66  PRO A N    1 
ATOM   994  C CA   . PRO A 1 69  ? 28.19559 -3.51742  0.68345  1.000 52.99352  ? 66  PRO A CA   1 
ATOM   995  C C    . PRO A 1 69  ? 29.04007 -2.67184  1.63289  1.000 46.42290  ? 66  PRO A C    1 
ATOM   996  O O    . PRO A 1 69  ? 28.97578 -1.43850  1.59050  1.000 42.21420  ? 66  PRO A O    1 
ATOM   997  C CB   . PRO A 1 69  ? 29.02603 -3.99326  -0.50898 1.000 54.19422  ? 66  PRO A CB   1 
ATOM   998  C CG   . PRO A 1 69  ? 28.91599 -2.82907  -1.48141 1.000 62.39676  ? 66  PRO A CG   1 
ATOM   999  C CD   . PRO A 1 69  ? 27.53471 -2.21374  -1.27142 1.000 55.70678  ? 66  PRO A CD   1 
ATOM   1000 H HA   . PRO A 1 69  ? 27.83980 -4.28554  1.15706  1.000 63.61121  ? 66  PRO A HA   1 
ATOM   1001 H HB2  . PRO A 1 69  ? 29.94573 -4.14721  -0.24186 1.000 65.05205  ? 66  PRO A HB2  1 
ATOM   1002 H HB3  . PRO A 1 69  ? 28.64876 -4.80502  -0.88262 1.000 65.05205  ? 66  PRO A HB3  1 
ATOM   1003 H HG2  . PRO A 1 69  ? 29.61085 -2.17998  -1.28971 1.000 74.89509  ? 66  PRO A HG2  1 
ATOM   1004 H HG3  . PRO A 1 69  ? 29.00884 -3.15591  -2.38996 1.000 74.89509  ? 66  PRO A HG3  1 
ATOM   1005 H HD2  . PRO A 1 69  ? 27.58653 -1.24518  -1.26187 1.000 66.86711  ? 66  PRO A HD2  1 
ATOM   1006 H HD3  . PRO A 1 69  ? 26.91847 -2.50622  -1.96107 1.000 66.86711  ? 66  PRO A HD3  1 
ATOM   1007 N N    . TYR A 1 70  ? 29.83483 -3.33028  2.46884  1.000 35.49971  ? 67  TYR A N    1 
ATOM   1008 C CA   . TYR A 1 70  ? 30.66330 -2.66257  3.45956  1.000 31.31082  ? 67  TYR A CA   1 
ATOM   1009 C C    . TYR A 1 70  ? 32.13095 -2.83380  3.11066  1.000 29.12416  ? 67  TYR A C    1 
ATOM   1010 O O    . TYR A 1 70  ? 32.54076 -3.88287  2.61702  1.000 29.18998  ? 67  TYR A O    1 
ATOM   1011 C CB   . TYR A 1 70  ? 30.37851 -3.22349  4.85635  1.000 30.22327  ? 67  TYR A CB   1 
ATOM   1012 C CG   . TYR A 1 70  ? 28.96290 -2.97095  5.30300  1.000 30.18699  ? 67  TYR A CG   1 
ATOM   1013 C CD1  . TYR A 1 70  ? 27.95601 -3.87604  5.03238  1.000 33.97772  ? 67  TYR A CD1  1 
ATOM   1014 C CD2  . TYR A 1 70  ? 28.63279 -1.81293  5.98207  1.000 31.18979  ? 67  TYR A CD2  1 
ATOM   1015 C CE1  . TYR A 1 70  ? 26.65728 -3.64148  5.44872  1.000 31.28707  ? 67  TYR A CE1  1 
ATOM   1016 C CE2  . TYR A 1 70  ? 27.34189 -1.56667  6.39168  1.000 33.58360  ? 67  TYR A CE2  1 
ATOM   1017 C CZ   . TYR A 1 70  ? 26.35586 -2.48140  6.11265  1.000 35.32436  ? 67  TYR A CZ   1 
ATOM   1018 O OH   . TYR A 1 70  ? 25.07363 -2.23281  6.52564  1.000 36.33532  ? 67  TYR A OH   1 
ATOM   1019 H H    . TYR A 1 70  ? 29.91165 -4.18677  2.47976  1.000 42.61864  ? 67  TYR A H    1 
ATOM   1020 H HA   . TYR A 1 70  ? 30.47219 -1.71160  3.46562  1.000 37.59196  ? 67  TYR A HA   1 
ATOM   1021 H HB2  . TYR A 1 70  ? 30.52519 -4.18231  4.84826  1.000 36.28691  ? 67  TYR A HB2  1 
ATOM   1022 H HB3  . TYR A 1 70  ? 30.97530 -2.80195  5.49435  1.000 36.28691  ? 67  TYR A HB3  1 
ATOM   1023 H HD1  . TYR A 1 70  ? 28.15342 -4.65457  4.56352  1.000 40.79225  ? 67  TYR A HD1  1 
ATOM   1024 H HD2  . TYR A 1 70  ? 29.29624 -1.18766  6.16586  1.000 37.44673  ? 67  TYR A HD2  1 
ATOM   1025 H HE1  . TYR A 1 70  ? 25.99190 -4.26856  5.27860  1.000 37.56346  ? 67  TYR A HE1  1 
ATOM   1026 H HE2  . TYR A 1 70  ? 27.13863 -0.78596  6.85437  1.000 40.31930  ? 67  TYR A HE2  1 
ATOM   1027 H HH   . TYR A 1 70  ? 24.56468 -2.85026  6.27006  1.000 43.62137  ? 67  TYR A HH   1 
ATOM   1028 N N    . ASP A 1 71  ? 32.91686 -1.79446  3.37112  1.000 25.55143  ? 68  ASP A N    1 
ATOM   1029 C CA   . ASP A 1 71  ? 34.34943 -1.85873  3.12669  1.000 27.43694  ? 68  ASP A CA   1 
ATOM   1030 C C    . ASP A 1 71  ? 35.06934 -2.74471  4.13457  1.000 26.58331  ? 68  ASP A C    1 
ATOM   1031 O O    . ASP A 1 71  ? 36.15664 -3.24729  3.83086  1.000 27.31374  ? 68  ASP A O    1 
ATOM   1032 C CB   . ASP A 1 71  ? 34.93430 -0.44735  3.15324  1.000 28.86986  ? 68  ASP A CB   1 
ATOM   1033 C CG   . ASP A 1 71  ? 34.29177 0.46482   2.11968  1.000 32.10139  ? 68  ASP A CG   1 
ATOM   1034 O OD1  . ASP A 1 71  ? 34.57636 0.29516   0.91749  1.000 35.76260  ? 68  ASP A OD1  1 
ATOM   1035 O OD2  . ASP A 1 71  ? 33.47866 1.32426   2.50463  1.000 29.37030  ? 68  ASP A OD2  1 
ATOM   1036 H H    . ASP A 1 71  ? 32.64510 -1.04297  3.68893  1.000 30.68069  ? 68  ASP A H    1 
ATOM   1037 H HA   . ASP A 1 71  ? 34.50516 -2.23469  2.24618  1.000 32.94330  ? 68  ASP A HA   1 
ATOM   1038 H HB2  . ASP A 1 71  ? 34.78821 -0.05945  4.03022  1.000 34.66282  ? 68  ASP A HB2  1 
ATOM   1039 H HB3  . ASP A 1 71  ? 35.88476 -0.49383  2.96517  1.000 34.66282  ? 68  ASP A HB3  1 
ATOM   1040 N N    . VAL A 1 72  ? 34.49869 -2.93563  5.32084  1.000 23.69547  ? 69  VAL A N    1 
ATOM   1041 C CA   . VAL A 1 72  ? 35.04065 -3.86245  6.30791  1.000 24.69052  ? 69  VAL A CA   1 
ATOM   1042 C C    . VAL A 1 72  ? 33.88385 -4.47809  7.09072  1.000 24.32804  ? 69  VAL A C    1 
ATOM   1043 O O    . VAL A 1 72  ? 32.88328 -3.81525  7.38968  1.000 23.78714  ? 69  VAL A O    1 
ATOM   1044 C CB   . VAL A 1 72  ? 36.04527 -3.15979  7.24727  1.000 22.80451  ? 69  VAL A CB   1 
ATOM   1045 C CG1  . VAL A 1 72  ? 35.34599 -2.11366  8.08931  1.000 23.89568  ? 69  VAL A CG1  1 
ATOM   1046 C CG2  . VAL A 1 72  ? 36.74638 -4.18799  8.13634  1.000 24.17360  ? 69  VAL A CG2  1 
ATOM   1047 H H    . VAL A 1 72  ? 33.78480 -2.53291  5.58117  1.000 28.45354  ? 69  VAL A H    1 
ATOM   1048 H HA   . VAL A 1 72  ? 35.50363 -4.57920  5.84657  1.000 29.64760  ? 69  VAL A HA   1 
ATOM   1049 H HB   . VAL A 1 72  ? 36.71759 -2.71108  6.71105  1.000 27.38440  ? 69  VAL A HB   1 
ATOM   1050 H HG11 . VAL A 1 72  ? 36.01340 -1.55267  8.51446  1.000 28.69380  ? 69  VAL A HG11 1 
ATOM   1051 H HG12 . VAL A 1 72  ? 34.77770 -1.57536  7.51644  1.000 28.69380  ? 69  VAL A HG12 1 
ATOM   1052 H HG13 . VAL A 1 72  ? 34.80930 -2.55836  8.76393  1.000 28.69380  ? 69  VAL A HG13 1 
ATOM   1053 H HG21 . VAL A 1 72  ? 37.46455 -3.75022  8.61955  1.000 29.02730  ? 69  VAL A HG21 1 
ATOM   1054 H HG22 . VAL A 1 72  ? 36.10274 -4.55562  8.76202  1.000 29.02730  ? 69  VAL A HG22 1 
ATOM   1055 H HG23 . VAL A 1 72  ? 37.10615 -4.89505  7.57819  1.000 29.02730  ? 69  VAL A HG23 1 
ATOM   1056 N N    . VAL A 1 73  ? 34.02189 -5.76101  7.40944  1.000 23.89921  ? 70  VAL A N    1 
ATOM   1057 C CA   . VAL A 1 73  ? 33.12680 -6.45713  8.32609  1.000 21.67815  ? 70  VAL A CA   1 
ATOM   1058 C C    . VAL A 1 73  ? 33.94764 -6.82415  9.55378  1.000 22.77596  ? 70  VAL A C    1 
ATOM   1059 O O    . VAL A 1 73  ? 35.02069 -7.43095  9.43018  1.000 21.61860  ? 70  VAL A O    1 
ATOM   1060 C CB   . VAL A 1 73  ? 32.49573 -7.70525  7.68799  1.000 25.22546  ? 70  VAL A CB   1 
ATOM   1061 C CG1  . VAL A 1 73  ? 31.62428 -8.41951  8.69999  1.000 24.44237  ? 70  VAL A CG1  1 
ATOM   1062 C CG2  . VAL A 1 73  ? 31.67656 -7.30412  6.46306  1.000 26.69147  ? 70  VAL A CG2  1 
ATOM   1063 H H    . VAL A 1 73  ? 34.64595 -6.26373  7.09732  1.000 28.69803  ? 70  VAL A H    1 
ATOM   1064 H HA   . VAL A 1 73  ? 32.40074 -5.86859  8.58561  1.000 26.03276  ? 70  VAL A HA   1 
ATOM   1065 H HB   . VAL A 1 73  ? 33.19498 -8.31441  7.40362  1.000 30.28954  ? 70  VAL A HB   1 
ATOM   1066 H HG11 . VAL A 1 73  ? 31.10675 -9.10224  8.24508  1.000 29.34983  ? 70  VAL A HG11 1 
ATOM   1067 H HG12 . VAL A 1 73  ? 32.19136 -8.82773  9.37280  1.000 29.34983  ? 70  VAL A HG12 1 
ATOM   1068 H HG13 . VAL A 1 73  ? 31.02960 -7.77538  9.11514  1.000 29.34983  ? 70  VAL A HG13 1 
ATOM   1069 H HG21 . VAL A 1 73  ? 31.28166 -8.09958  6.07293  1.000 32.04875  ? 70  VAL A HG21 1 
ATOM   1070 H HG22 . VAL A 1 73  ? 30.97865 -6.68890  6.73752  1.000 32.04875  ? 70  VAL A HG22 1 
ATOM   1071 H HG23 . VAL A 1 73  ? 32.26120 -6.87505  5.81886  1.000 32.04875  ? 70  VAL A HG23 1 
ATOM   1072 N N    . VAL A 1 74  ? 33.45800 -6.44233  10.73235 1.000 21.27140  ? 71  VAL A N    1 
ATOM   1073 C CA   . VAL A 1 74  ? 34.20966 -6.55219  11.97737 1.000 20.86361  ? 71  VAL A CA   1 
ATOM   1074 C C    . VAL A 1 74  ? 33.51622 -7.57069  12.86900 1.000 21.67803  ? 71  VAL A C    1 
ATOM   1075 O O    . VAL A 1 74  ? 32.31883 -7.45121  13.15466 1.000 20.92741  ? 71  VAL A O    1 
ATOM   1076 C CB   . VAL A 1 74  ? 34.33946 -5.18996  12.68334 1.000 20.83047  ? 71  VAL A CB   1 
ATOM   1077 C CG1  . VAL A 1 74  ? 35.11139 -5.34428  13.97880 1.000 21.25411  ? 71  VAL A CG1  1 
ATOM   1078 C CG2  . VAL A 1 74  ? 35.00288 -4.18521  11.77989 1.000 20.95485  ? 71  VAL A CG2  1 
ATOM   1079 H H    . VAL A 1 74  ? 32.67233 -6.10837  10.83625 1.000 25.54466  ? 71  VAL A H    1 
ATOM   1080 H HA   . VAL A 1 74  ? 35.10272 -6.87756  11.78376 1.000 25.05531  ? 71  VAL A HA   1 
ATOM   1081 H HB   . VAL A 1 74  ? 33.45345 -4.85704  12.89556 1.000 25.01554  ? 71  VAL A HB   1 
ATOM   1082 H HG11 . VAL A 1 74  ? 35.36717 -4.46568  14.30059 1.000 25.52392  ? 71  VAL A HG11 1 
ATOM   1083 H HG12 . VAL A 1 74  ? 34.54610 -5.78441  14.63275 1.000 25.52392  ? 71  VAL A HG12 1 
ATOM   1084 H HG13 . VAL A 1 74  ? 35.90333 -5.87920  13.81272 1.000 25.52392  ? 71  VAL A HG13 1 
ATOM   1085 H HG21 . VAL A 1 74  ? 35.08964 -3.34329  12.25375 1.000 25.16480  ? 71  VAL A HG21 1 
ATOM   1086 H HG22 . VAL A 1 74  ? 35.87981 -4.51594  11.52985 1.000 25.16480  ? 71  VAL A HG22 1 
ATOM   1087 H HG23 . VAL A 1 74  ? 34.45675 -4.06402  10.98746 1.000 25.16480  ? 71  VAL A HG23 1 
ATOM   1088 N N    . LEU A 1 75  ? 34.27453 -8.55781  13.31830 1.000 20.42120  ? 72  LEU A N    1 
ATOM   1089 C CA   . LEU A 1 75  ? 33.77587 -9.59411  14.21259 1.000 20.22892  ? 72  LEU A CA   1 
ATOM   1090 C C    . LEU A 1 75  ? 34.45143 -9.44689  15.56778 1.000 20.76061  ? 72  LEU A C    1 
ATOM   1091 O O    . LEU A 1 75  ? 35.65294 -9.75603  15.69101 1.000 19.62233  ? 72  LEU A O    1 
ATOM   1092 C CB   . LEU A 1 75  ? 34.05605 -10.97834 13.63373 1.000 21.52135  ? 72  LEU A CB   1 
ATOM   1093 C CG   . LEU A 1 75  ? 33.54587 -11.27670 12.22068 1.000 23.04765  ? 72  LEU A CG   1 
ATOM   1094 C CD1  . LEU A 1 75  ? 34.01508 -12.67943 11.82055 1.000 31.40470  ? 72  LEU A CD1  1 
ATOM   1095 C CD2  . LEU A 1 75  ? 32.05742 -11.15238 12.15234 1.000 25.58028  ? 72  LEU A CD2  1 
ATOM   1096 H H    . LEU A 1 75  ? 35.10465 -8.65390  13.11518 1.000 24.52442  ? 72  LEU A H    1 
ATOM   1097 H HA   . LEU A 1 75  ? 32.81749 -9.49408  14.32395 1.000 24.29369  ? 72  LEU A HA   1 
ATOM   1098 H HB2  . LEU A 1 75  ? 35.01797 -11.10197 13.61569 1.000 25.84460  ? 72  LEU A HB2  1 
ATOM   1099 H HB3  . LEU A 1 75  ? 33.64842 -11.63284 14.22226 1.000 25.84460  ? 72  LEU A HB3  1 
ATOM   1100 H HG   . LEU A 1 75  ? 33.90281 -10.63368 11.58820 1.000 27.67616  ? 72  LEU A HG   1 
ATOM   1101 H HD11 . LEU A 1 75  ? 33.67071 -12.88785 10.93801 1.000 37.70462  ? 72  LEU A HD11 1 
ATOM   1102 H HD12 . LEU A 1 75  ? 34.98487 -12.69694 11.80983 1.000 37.70462  ? 72  LEU A HD12 1 
ATOM   1103 H HD13 . LEU A 1 75  ? 33.67979 -13.32078 12.46641 1.000 37.70462  ? 72  LEU A HD13 1 
ATOM   1104 H HD21 . LEU A 1 75  ? 31.76064 -11.39695 11.26183 1.000 30.71532  ? 72  LEU A HD21 1 
ATOM   1105 H HD22 . LEU A 1 75  ? 31.66044 -11.74668 12.80816 1.000 30.71532  ? 72  LEU A HD22 1 
ATOM   1106 H HD23 . LEU A 1 75  ? 31.80804 -10.23472 12.34372 1.000 30.71532  ? 72  LEU A HD23 1 
ATOM   1107 N N    . PRO A 1 76  ? 33.74956 -8.95751  16.59157 1.000 20.39004  ? 73  PRO A N    1 
ATOM   1108 C CA   . PRO A 1 76  ? 34.34533 -8.89369  17.93011 1.000 21.98309  ? 73  PRO A CA   1 
ATOM   1109 C C    . PRO A 1 76  ? 34.54588 -10.29200 18.48546 1.000 21.50440  ? 73  PRO A C    1 
ATOM   1110 O O    . PRO A 1 76  ? 34.04943 -11.28770 17.94997 1.000 20.89884  ? 73  PRO A O    1 
ATOM   1111 C CB   . PRO A 1 76  ? 33.32440 -8.10731  18.76323 1.000 20.35466  ? 73  PRO A CB   1 
ATOM   1112 C CG   . PRO A 1 76  ? 32.40190 -7.44811  17.74870 1.000 24.81622  ? 73  PRO A CG   1 
ATOM   1113 C CD   . PRO A 1 76  ? 32.39122 -8.37933  16.56308 1.000 22.66774  ? 73  PRO A CD   1 
ATOM   1114 H HA   . PRO A 1 76  ? 35.18387 -8.40634  17.91419 1.000 26.39868  ? 73  PRO A HA   1 
ATOM   1115 H HB2  . PRO A 1 76  ? 32.83077 -8.71396  19.33699 1.000 24.44457  ? 73  PRO A HB2  1 
ATOM   1116 H HB3  . PRO A 1 76  ? 33.78119 -7.44087  19.29998 1.000 24.44457  ? 73  PRO A HB3  1 
ATOM   1117 H HG2  . PRO A 1 76  ? 31.51213 -7.35464  18.12349 1.000 29.79845  ? 73  PRO A HG2  1 
ATOM   1118 H HG3  . PRO A 1 76  ? 32.75108 -6.57744  17.50191 1.000 29.79845  ? 73  PRO A HG3  1 
ATOM   1119 H HD2  . PRO A 1 76  ? 31.71769 -9.06925  16.66925 1.000 27.22027  ? 73  PRO A HD2  1 
ATOM   1120 H HD3  . PRO A 1 76  ? 32.23877 -7.89087  15.73903 1.000 27.22027  ? 73  PRO A HD3  1 
ATOM   1121 N N    . GLY A 1 77  ? 35.25779 -10.34712 19.60163 1.000 20.66705  ? 74  GLY A N    1 
ATOM   1122 C CA   . GLY A 1 77  ? 35.54340 -11.57459 20.29113 1.000 20.76359  ? 74  GLY A CA   1 
ATOM   1123 C C    . GLY A 1 77  ? 34.59295 -11.80781 21.44259 1.000 22.25905  ? 74  GLY A C    1 
ATOM   1124 O O    . GLY A 1 77  ? 33.44181 -11.36263 21.42531 1.000 19.57656  ? 74  GLY A O    1 
ATOM   1125 H H    A GLY A 1 77  ? 35.59446 -9.65510  19.98551 0.918 24.81944  ? 74  GLY A H    1 
ATOM   1126 H H    B GLY A 1 77  ? 35.59446 -9.65510  19.98551 0.082 24.81944  ? 74  GLY A H    1 
ATOM   1127 H HA2  . GLY A 1 77  ? 35.46620 -12.31795 19.67279 1.000 24.93528  ? 74  GLY A HA2  1 
ATOM   1128 H HA3  . GLY A 1 77  ? 36.44819 -11.54636 20.63964 1.000 24.93528  ? 74  GLY A HA3  1 
ATOM   1129 N N    . GLY A 1 78  ? 35.10235 -12.43886 22.49541 1.000 21.61714  ? 75  GLY A N    1 
ATOM   1130 C CA   . GLY A 1 78  ? 34.24784 -12.99783 23.53015 1.000 20.96899  ? 75  GLY A CA   1 
ATOM   1131 C C    . GLY A 1 78  ? 33.85968 -14.41436 23.14081 1.000 25.32505  ? 75  GLY A C    1 
ATOM   1132 O O    . GLY A 1 78  ? 33.35297 -14.62863 22.03369 1.000 23.01189  ? 75  GLY A O    1 
ATOM   1133 H H    . GLY A 1 78  ? 35.94326 -12.55597 22.63236 1.000 25.95955  ? 75  GLY A H    1 
ATOM   1134 H HA2  . GLY A 1 78  ? 34.71884 -13.01664 24.37791 1.000 25.18177  ? 75  GLY A HA2  1 
ATOM   1135 H HA3  . GLY A 1 78  ? 33.44556 -12.46120 23.62646 1.000 25.18177  ? 75  GLY A HA3  1 
ATOM   1136 N N    . ASN A 1 79  ? 34.11869 -15.39056 24.02001 1.000 24.45745  ? 76  ASN A N    1 
ATOM   1137 C CA   . ASN A 1 79  ? 33.93902 -16.79815 23.65822 1.000 27.39756  ? 76  ASN A CA   1 
ATOM   1138 C C    . ASN A 1 79  ? 32.51418 -17.08130 23.20475 1.000 25.96798  ? 76  ASN A C    1 
ATOM   1139 O O    . ASN A 1 79  ? 32.29605 -17.66273 22.13611 1.000 25.35236  ? 76  ASN A O    1 
ATOM   1140 C CB   . ASN A 1 79  ? 34.30978 -17.70024 24.83629 1.000 29.72622  ? 76  ASN A CB   1 
ATOM   1141 C CG   . ASN A 1 79  ? 35.80617 -17.77014 25.06117 1.000 43.54848  ? 76  ASN A CG   1 
ATOM   1142 O OD1  . ASN A 1 79  ? 36.59466 -17.48350 24.16127 1.000 57.26284  ? 76  ASN A OD1  1 
ATOM   1143 N ND2  . ASN A 1 79  ? 36.20472 -18.15826 26.26057 1.000 53.54102  ? 76  ASN A ND2  1 
ATOM   1144 H H    . ASN A 1 79  ? 34.39669 -15.26449 24.82401 1.000 29.36792  ? 76  ASN A H    1 
ATOM   1145 H HA   . ASN A 1 79  ? 34.53596 -16.99904 22.92051 1.000 32.89606  ? 76  ASN A HA   1 
ATOM   1146 H HB2  . ASN A 1 79  ? 33.89952 -17.35275 25.64365 1.000 35.69044  ? 76  ASN A HB2  1 
ATOM   1147 H HB3  . ASN A 1 79  ? 33.98893 -18.59877 24.66139 1.000 35.69044  ? 76  ASN A HB3  1 
ATOM   1148 H HD21 . ASN A 1 79  ? 37.04448 -18.21394 26.43750 1.000 64.26820  ? 76  ASN A HD21 1 
ATOM   1149 H HD22 . ASN A 1 79  ? 35.62421 -18.35505 26.86379 1.000 64.26820  ? 76  ASN A HD22 1 
ATOM   1150 N N    . LEU A 1 80  ? 31.52405 -16.66249 23.99608 1.000 22.95340  ? 77  LEU A N    1 
ATOM   1151 C CA   . LEU A 1 80  ? 30.13871 -16.95910 23.63933 1.000 27.27767  ? 77  LEU A CA   1 
ATOM   1152 C C    . LEU A 1 80  ? 29.66642 -16.11538 22.46272 1.000 25.53805  ? 77  LEU A C    1 
ATOM   1153 O O    . LEU A 1 80  ? 28.86838 -16.58429 21.64359 1.000 25.13197  ? 77  LEU A O    1 
ATOM   1154 C CB   . LEU A 1 80  ? 29.23816 -16.75523 24.85152 1.000 28.55482  ? 77  LEU A CB   1 
ATOM   1155 C CG   . LEU A 1 80  ? 29.58962 -17.66516 26.04215 1.000 33.67187  ? 77  LEU A CG   1 
ATOM   1156 C CD1  . LEU A 1 80  ? 28.64352 -17.39588 27.21680 1.000 49.88729  ? 77  LEU A CD1  1 
ATOM   1157 C CD2  . LEU A 1 80  ? 29.54269 -19.12645 25.64883 1.000 47.31762  ? 77  LEU A CD2  1 
ATOM   1158 H H    . LEU A 1 80  ? 31.62557 -16.21719 24.72479 1.000 27.56306  ? 77  LEU A H    1 
ATOM   1159 H HA   . LEU A 1 80  ? 30.07217 -17.88970 23.37392 1.000 32.75218  ? 77  LEU A HA   1 
ATOM   1160 H HB2  . LEU A 1 80  ? 29.31752 -15.83484 25.14730 1.000 34.28477  ? 77  LEU A HB2  1 
ATOM   1161 H HB3  . LEU A 1 80  ? 28.32201 -16.94316 24.59414 1.000 34.28477  ? 77  LEU A HB3  1 
ATOM   1162 H HG   . LEU A 1 80  ? 30.49600 -17.46699 26.32517 1.000 40.42523  ? 77  LEU A HG   1 
ATOM   1163 H HD11 . LEU A 1 80  ? 28.88593 -17.97453 27.95660 1.000 59.88373  ? 77  LEU A HD11 1 
ATOM   1164 H HD12 . LEU A 1 80  ? 28.72662 -16.46672 27.48263 1.000 59.88373  ? 77  LEU A HD12 1 
ATOM   1165 H HD13 . LEU A 1 80  ? 27.73300 -17.57987 26.93753 1.000 59.88373  ? 77  LEU A HD13 1 
ATOM   1166 H HD21 . LEU A 1 80  ? 30.31524 -19.33043 25.09886 1.000 56.80013  ? 77  LEU A HD21 1 
ATOM   1167 H HD22 . LEU A 1 80  ? 29.55553 -19.67023 26.45197 1.000 56.80013  ? 77  LEU A HD22 1 
ATOM   1168 H HD23 . LEU A 1 80  ? 28.72793 -19.29309 25.14953 1.000 56.80013  ? 77  LEU A HD23 1 
ATOM   1169 N N    . GLY A 1 81  ? 30.16058 -14.88578 22.34298 1.000 22.70058  ? 78  GLY A N    1 
ATOM   1170 C CA   . GLY A 1 81  ? 29.83678 -14.09932 21.16829 1.000 23.55803  ? 78  GLY A CA   1 
ATOM   1171 C C    . GLY A 1 81  ? 30.33196 -14.76051 19.89804 1.000 23.93034  ? 78  GLY A C    1 
ATOM   1172 O O    . GLY A 1 81  ? 29.61536 -14.83585 18.89466 1.000 23.82539  ? 78  GLY A O    1 
ATOM   1173 H H    . GLY A 1 81  ? 30.67205 -14.49672 22.91450 1.000 27.25967  ? 78  GLY A H    1 
ATOM   1174 H HA2  . GLY A 1 81  ? 28.87478 -13.99194 21.10560 1.000 28.28861  ? 78  GLY A HA2  1 
ATOM   1175 H HA3  . GLY A 1 81  ? 30.24817 -13.22392 21.24121 1.000 28.28861  ? 78  GLY A HA3  1 
ATOM   1176 N N    . ALA A 1 82  ? 31.57498 -15.24663 19.92660 1.000 22.24977  ? 79  ALA A N    1 
ATOM   1177 C CA   . ALA A 1 82  ? 32.15148 -15.89102 18.75162 1.000 24.87989  ? 79  ALA A CA   1 
ATOM   1178 C C    . ALA A 1 82  ? 31.40525 -17.17638 18.40395 1.000 25.86890  ? 79  ALA A C    1 
ATOM   1179 O O    . ALA A 1 82  ? 31.23534 -17.50449 17.22137 1.000 25.04816  ? 79  ALA A O    1 
ATOM   1180 C CB   . ALA A 1 82  ? 33.63462 -16.17794 18.98469 1.000 24.75304  ? 79  ALA A CB   1 
ATOM   1181 H H    . ALA A 1 82  ? 32.09884 -15.21552 20.60793 1.000 26.71870  ? 79  ALA A H    1 
ATOM   1182 H HA   . ALA A 1 82  ? 32.07776 -15.28654 17.99659 1.000 29.87485  ? 79  ALA A HA   1 
ATOM   1183 H HB1  . ALA A 1 82  ? 34.00119 -16.60653 18.19549 1.000 29.72263  ? 79  ALA A HB1  1 
ATOM   1184 H HB2  . ALA A 1 82  ? 34.09587 -15.34098 19.15097 1.000 29.72263  ? 79  ALA A HB2  1 
ATOM   1185 H HB3  . ALA A 1 82  ? 33.72608 -16.76416 19.75208 1.000 29.72263  ? 79  ALA A HB3  1 
ATOM   1186 N N    A GLN A 1 83  ? 30.94395 -17.91351 19.41883 0.474 26.18046  ? 80  GLN A N    1 
ATOM   1187 N N    B GLN A 1 83  ? 30.95482 -17.91943 19.41939 0.526 26.11787  ? 80  GLN A N    1 
ATOM   1188 C CA   A GLN A 1 83  ? 30.17163 -19.12542 19.15831 0.474 28.62705  ? 80  GLN A CA   1 
ATOM   1189 C CA   B GLN A 1 83  ? 30.16979 -19.12220 19.15741 0.526 28.53714  ? 80  GLN A CA   1 
ATOM   1190 C C    A GLN A 1 83  ? 28.84333 -18.79560 18.48630 0.474 28.56767  ? 80  GLN A C    1 
ATOM   1191 C C    B GLN A 1 83  ? 28.86038 -18.77396 18.46087 0.526 28.71971  ? 80  GLN A C    1 
ATOM   1192 O O    A GLN A 1 83  ? 28.41375 -19.50065 17.56512 0.474 28.63789  ? 80  GLN A O    1 
ATOM   1193 O O    B GLN A 1 83  ? 28.46018 -19.44157 17.49917 0.526 28.30370  ? 80  GLN A O    1 
ATOM   1194 C CB   A GLN A 1 83  ? 29.94252 -19.88934 20.46244 0.474 31.97423  ? 80  GLN A CB   1 
ATOM   1195 C CB   B GLN A 1 83  ? 29.89896 -19.86854 20.46286 0.526 32.02559  ? 80  GLN A CB   1 
ATOM   1196 C CG   A GLN A 1 83  ? 31.21065 -20.47938 21.06401 0.474 34.07389  ? 80  GLN A CG   1 
ATOM   1197 C CG   B GLN A 1 83  ? 29.14591 -21.17898 20.28325 0.526 36.08054  ? 80  GLN A CG   1 
ATOM   1198 C CD   A GLN A 1 83  ? 30.98538 -21.10104 22.43298 0.474 42.94068  ? 80  GLN A CD   1 
ATOM   1199 C CD   B GLN A 1 83  ? 28.78829 -21.83092 21.60890 0.526 46.46757  ? 80  GLN A CD   1 
ATOM   1200 O OE1  A GLN A 1 83  ? 29.86629 -21.46870 22.78345 0.474 60.76900  ? 80  GLN A OE1  1 
ATOM   1201 O OE1  B GLN A 1 83  ? 29.27812 -21.42833 22.66471 0.526 62.12228  ? 80  GLN A OE1  1 
ATOM   1202 N NE2  A GLN A 1 83  ? 32.05122 -21.20778 23.21860 0.474 37.83315  ? 80  GLN A NE2  1 
ATOM   1203 N NE2  B GLN A 1 83  ? 27.92519 -22.84019 21.55939 0.526 59.06938  ? 80  GLN A NE2  1 
ATOM   1204 H H    A GLN A 1 83  ? 31.06308 -17.73555 20.25174 0.474 31.43554  ? 80  GLN A H    1 
ATOM   1205 H H    B GLN A 1 83  ? 31.08833 -17.75068 20.25203 0.526 31.36042  ? 80  GLN A H    1 
ATOM   1206 H HA   A GLN A 1 83  ? 30.67633 -19.69904 18.56069 0.474 34.37144  ? 80  GLN A HA   1 
ATOM   1207 H HA   B GLN A 1 83  ? 30.67805 -19.71042 18.57726 0.526 34.26355  ? 80  GLN A HA   1 
ATOM   1208 H HB2  A GLN A 1 83  ? 29.56056 -19.28231 21.11553 0.474 38.38806  ? 80  GLN A HB2  1 
ATOM   1209 H HB2  B GLN A 1 83  ? 30.74762 -20.07174 20.88639 0.526 38.44969  ? 80  GLN A HB2  1 
ATOM   1210 H HB3  A GLN A 1 83  ? 29.32902 -20.62082 20.29079 0.474 38.38806  ? 80  GLN A HB3  1 
ATOM   1211 H HB3  B GLN A 1 83  ? 29.36725 -19.29975 21.04137 0.526 38.44969  ? 80  GLN A HB3  1 
ATOM   1212 H HG2  A GLN A 1 83  ? 31.54732 -21.17121 20.47332 0.474 40.90765  ? 80  GLN A HG2  1 
ATOM   1213 H HG2  B GLN A 1 83  ? 28.32237 -21.00778 19.80016 0.526 43.31563  ? 80  GLN A HG2  1 
ATOM   1214 H HG3  A GLN A 1 83  ? 31.87085 -19.77530 21.16046 0.474 40.90765  ? 80  GLN A HG3  1 
ATOM   1215 H HG3  B GLN A 1 83  ? 29.70113 -21.79781 19.78358 0.526 43.31563  ? 80  GLN A HG3  1 
ATOM   1216 H HE21 A GLN A 1 83  ? 32.81778 -20.93184 22.94319 0.474 45.41877  ? 80  GLN A HE21 1 
ATOM   1217 H HE21 B GLN A 1 83  ? 27.60063 -23.09175 20.80375 0.526 70.90223  ? 80  GLN A HE21 1 
ATOM   1218 H HE22 A GLN A 1 83  ? 31.97470 -21.55283 24.00262 0.474 45.41877  ? 80  GLN A HE22 1 
ATOM   1219 H HE22 B GLN A 1 83  ? 27.69121 -23.24178 22.28297 0.526 70.90223  ? 80  GLN A HE22 1 
ATOM   1220 N N    . ASN A 1 84  ? 28.18329 -17.72061 18.92415 1.000 26.36313  ? 81  ASN A N    1 
ATOM   1221 C CA   . ASN A 1 84  ? 26.95200 -17.29805 18.26634 1.000 26.59313  ? 81  ASN A CA   1 
ATOM   1222 C C    . ASN A 1 84  ? 27.21793 -16.88080 16.82436 1.000 26.93859  ? 81  ASN A C    1 
ATOM   1223 O O    . ASN A 1 84  ? 26.42813 -17.18969 15.92537 1.000 27.58005  ? 81  ASN A O    1 
ATOM   1224 C CB   . ASN A 1 84  ? 26.29677 -16.16934 19.06115 1.000 27.61764  ? 81  ASN A CB   1 
ATOM   1225 C CG   . ASN A 1 84  ? 25.65684 -16.65894 20.33573 1.000 32.66778  ? 81  ASN A CG   1 
ATOM   1226 O OD1  . ASN A 1 84  ? 25.02732 -17.71267 20.36361 1.000 37.42643  ? 81  ASN A OD1  1 
ATOM   1227 N ND2  . ASN A 1 84  ? 25.81135 -15.89238 21.40232 1.000 30.55225  ? 81  ASN A ND2  1 
ATOM   1228 H H    A ASN A 1 84  ? 28.42429 -17.22937 19.58762 0.474 31.65474  ? 81  ASN A H    1 
ATOM   1229 H H    B ASN A 1 84  ? 28.41215 -17.24510 19.60320 0.526 31.65474  ? 81  ASN A H    1 
ATOM   1230 H HA   . ASN A 1 84  ? 26.32797 -18.04039 18.24630 1.000 31.93074  ? 81  ASN A HA   1 
ATOM   1231 H HB2  . ASN A 1 84  ? 26.97155 -15.51314 19.29560 1.000 33.16014  ? 81  ASN A HB2  1 
ATOM   1232 H HB3  . ASN A 1 84  ? 25.60766 -15.75680 18.51724 1.000 33.16014  ? 81  ASN A HB3  1 
ATOM   1233 H HD21 . ASN A 1 84  ? 25.46575 -16.12688 22.15410 1.000 36.68169  ? 81  ASN A HD21 1 
ATOM   1234 H HD22 . ASN A 1 84  ? 26.25742 -15.15942 21.34411 1.000 36.68169  ? 81  ASN A HD22 1 
ATOM   1235 N N    . LEU A 1 85  ? 28.33046 -16.18945 16.58054 1.000 23.70740  ? 82  LEU A N    1 
ATOM   1236 C CA   . LEU A 1 85  ? 28.68174 -15.82553 15.21301 1.000 24.71274  ? 82  LEU A CA   1 
ATOM   1237 C C    . LEU A 1 85  ? 28.96645 -17.06749 14.37548 1.000 26.17426  ? 82  LEU A C    1 
ATOM   1238 O O    . LEU A 1 85  ? 28.60848 -17.12979 13.19270 1.000 25.58290  ? 82  LEU A O    1 
ATOM   1239 C CB   . LEU A 1 85  ? 29.89828 -14.90230 15.21216 1.000 24.53654  ? 82  LEU A CB   1 
ATOM   1240 C CG   . LEU A 1 85  ? 29.73417 -13.51144 15.84341 1.000 25.14581  ? 82  LEU A CG   1 
ATOM   1241 C CD1  . LEU A 1 85  ? 31.07003 -12.80839 15.86529 1.000 24.98967  ? 82  LEU A CD1  1 
ATOM   1242 C CD2  . LEU A 1 85  ? 28.70189 -12.69714 15.12194 1.000 29.70587  ? 82  LEU A CD2  1 
ATOM   1243 H H    . LEU A 1 85  ? 28.88832 -15.92410 17.17886 1.000 28.46786  ? 82  LEU A H    1 
ATOM   1244 H HA   . LEU A 1 85  ? 27.93723 -15.34787 14.81495 1.000 29.67427  ? 82  LEU A HA   1 
ATOM   1245 H HB2  . LEU A 1 85  ? 30.60950 -15.34871 15.69774 1.000 29.46283  ? 82  LEU A HB2  1 
ATOM   1246 H HB3  . LEU A 1 85  ? 30.16350 -14.76229 14.28969 1.000 29.46283  ? 82  LEU A HB3  1 
ATOM   1247 H HG   . LEU A 1 85  ? 29.41916 -13.60873 16.75567 1.000 30.19395  ? 82  LEU A HG   1 
ATOM   1248 H HD11 . LEU A 1 85  ? 30.94304 -11.89864 16.17695 1.000 30.00658  ? 82  LEU A HD11 1 
ATOM   1249 H HD12 . LEU A 1 85  ? 31.66695 -13.28309 16.46467 1.000 30.00658  ? 82  LEU A HD12 1 
ATOM   1250 H HD13 . LEU A 1 85  ? 31.43840 -12.80226 14.96798 1.000 30.00658  ? 82  LEU A HD13 1 
ATOM   1251 H HD21 . LEU A 1 85  ? 28.68754 -11.80228 15.49600 1.000 35.66603  ? 82  LEU A HD21 1 
ATOM   1252 H HD22 . LEU A 1 85  ? 28.93171 -12.65842 14.18036 1.000 35.66603  ? 82  LEU A HD22 1 
ATOM   1253 H HD23 . LEU A 1 85  ? 27.83430 -13.11632 15.23371 1.000 35.66603  ? 82  LEU A HD23 1 
ATOM   1254 N N    . SER A 1 86  ? 29.60956 -18.07043 14.97681 1.000 24.76068  ? 83  SER A N    1 
ATOM   1255 C CA   . SER A 1 86  ? 29.98961 -19.26789 14.23440 1.000 28.47509  ? 83  SER A CA   1 
ATOM   1256 C C    . SER A 1 86  ? 28.77756 -20.08627 13.81120 1.000 30.04813  ? 83  SER A C    1 
ATOM   1257 O O    . SER A 1 86  ? 28.84890 -20.81961 12.82155 1.000 30.22817  ? 83  SER A O    1 
ATOM   1258 C CB   . SER A 1 86  ? 30.92551 -20.14172 15.07492 1.000 26.98026  ? 83  SER A CB   1 
ATOM   1259 O OG   . SER A 1 86  ? 32.16274 -19.49693 15.30530 1.000 29.32785  ? 83  SER A OG   1 
ATOM   1260 H H    . SER A 1 86  ? 29.83504 -18.08103 15.80666 1.000 29.73180  ? 83  SER A H    1 
ATOM   1261 H HA   . SER A 1 86  ? 30.46346 -18.98661 13.43612 1.000 34.18909  ? 83  SER A HA   1 
ATOM   1262 H HB2  . SER A 1 86  ? 30.50258 -20.32338 15.92876 1.000 32.39530  ? 83  SER A HB2  1 
ATOM   1263 H HB3  . SER A 1 86  ? 31.08809 -20.97273 14.60175 1.000 32.39530  ? 83  SER A HB3  1 
ATOM   1264 H HG   . SER A 1 86  ? 32.04373 -18.80121 15.76073 1.000 35.21240  ? 83  SER A HG   1 
ATOM   1265 N N    . GLU A 1 87  ? 27.67087 -19.98223 14.53978 1.000 29.08547  ? 84  GLU A N    1 
ATOM   1266 C CA   . GLU A 1 87  ? 26.48806 -20.78835 14.28581 1.000 33.68239  ? 84  GLU A CA   1 
ATOM   1267 C C    . GLU A 1 87  ? 25.46042 -20.08923 13.40550 1.000 34.74177  ? 84  GLU A C    1 
ATOM   1268 O O    . GLU A 1 87  ? 24.42648 -20.68907 13.09269 1.000 38.43652  ? 84  GLU A O    1 
ATOM   1269 C CB   . GLU A 1 87  ? 25.82863 -21.17766 15.61354 1.000 37.75503  ? 84  GLU A CB   1 
ATOM   1270 C CG   . GLU A 1 87  ? 26.66147 -22.07959 16.49584 1.000 41.79124  ? 84  GLU A CG   1 
ATOM   1271 C CD   . GLU A 1 87  ? 26.05036 -22.26435 17.87923 1.000 54.60109  ? 84  GLU A CD   1 
ATOM   1272 O OE1  . GLU A 1 87  ? 24.90439 -21.81312 18.09859 1.000 54.82060  ? 84  GLU A OE1  1 
ATOM   1273 O OE2  . GLU A 1 87  ? 26.72618 -22.84521 18.75297 1.000 68.75291  ? 84  GLU A OE2  1 
ATOM   1274 H H    . GLU A 1 87  ? 27.58115 -19.43924 15.20062 1.000 34.92155  ? 84  GLU A H    1 
ATOM   1275 H HA   . GLU A 1 87  ? 26.76475 -21.59861 13.82993 1.000 40.43786  ? 84  GLU A HA   1 
ATOM   1276 H HB2  . GLU A 1 87  ? 25.64524 -20.36784 16.11499 1.000 45.32502  ? 84  GLU A HB2  1 
ATOM   1277 H HB3  . GLU A 1 87  ? 24.99982 -21.64319 15.42049 1.000 45.32502  ? 84  GLU A HB3  1 
ATOM   1278 H HG2  . GLU A 1 87  ? 26.73364 -22.95258 16.07919 1.000 50.16848  ? 84  GLU A HG2  1 
ATOM   1279 H HG3  . GLU A 1 87  ? 27.54317 -21.69035 16.60537 1.000 50.16848  ? 84  GLU A HG3  1 
ATOM   1280 N N    . SER A 1 88  ? 25.71310 -18.85323 12.99129 1.000 31.88221  ? 85  SER A N    1 
ATOM   1281 C CA   . SER A 1 88  ? 24.72007 -18.06646 12.27274 1.000 32.03725  ? 85  SER A CA   1 
ATOM   1282 C C    . SER A 1 88  ? 24.90269 -18.22273 10.77038 1.000 30.96727  ? 85  SER A C    1 
ATOM   1283 O O    . SER A 1 88  ? 25.97617 -17.93559 10.23456 1.000 28.78679  ? 85  SER A O    1 
ATOM   1284 C CB   . SER A 1 88  ? 24.82225 -16.59438 12.65850 1.000 30.68466  ? 85  SER A CB   1 
ATOM   1285 O OG   . SER A 1 88  ? 24.04345 -15.79493 11.79541 1.000 32.29960  ? 85  SER A OG   1 
ATOM   1286 H H    . SER A 1 88  ? 26.45964 -18.44485 13.11582 1.000 38.27763  ? 85  SER A H    1 
ATOM   1287 H HA   . SER A 1 88  ? 23.83877 -18.39827 12.50537 1.000 38.46368  ? 85  SER A HA   1 
ATOM   1288 H HB2  . SER A 1 88  ? 24.50183 -16.48297 13.56724 1.000 36.84058  ? 85  SER A HB2  1 
ATOM   1289 H HB3  . SER A 1 88  ? 25.74920 -16.31530 12.59699 1.000 36.84058  ? 85  SER A HB3  1 
ATOM   1290 H HG   . SER A 1 88  ? 24.11360 -14.98624 12.01153 1.000 38.77850  ? 85  SER A HG   1 
ATOM   1291 N N    . ALA A 1 89  ? 23.84507 -18.65955 10.09047 1.000 31.59529  ? 86  ALA A N    1 
ATOM   1292 C CA   . ALA A 1 89  ? 23.88231 -18.73406 8.63167  1.000 34.97460  ? 86  ALA A CA   1 
ATOM   1293 C C    . ALA A 1 89  ? 23.95355 -17.34906 8.00100  1.000 30.56881  ? 86  ALA A C    1 
ATOM   1294 O O    . ALA A 1 89  ? 24.58307 -17.17381 6.94852  1.000 30.34736  ? 86  ALA A O    1 
ATOM   1295 C CB   . ALA A 1 89  ? 22.64883 -19.47532 8.10928  1.000 35.14925  ? 86  ALA A CB   1 
ATOM   1296 H H    . ALA A 1 89  ? 23.10379 -18.91540 10.44352 1.000 37.93333  ? 86  ALA A H    1 
ATOM   1297 H HA   . ALA A 1 89  ? 24.67230 -19.23219 8.36959  1.000 41.98850  ? 86  ALA A HA   1 
ATOM   1298 H HB1  . ALA A 1 89  ? 22.70133 -19.53355 7.14245  1.000 42.19809  ? 86  ALA A HB1  1 
ATOM   1299 H HB2  . ALA A 1 89  ? 22.62913 -20.36568 8.49369  1.000 42.19809  ? 86  ALA A HB2  1 
ATOM   1300 H HB3  . ALA A 1 89  ? 21.85273 -18.98545 8.36842  1.000 42.19809  ? 86  ALA A HB3  1 
ATOM   1301 N N    . ALA A 1 90  ? 23.32096 -16.35427 8.62790  1.000 29.86863  ? 87  ALA A N    1 
ATOM   1302 C CA   . ALA A 1 90  ? 23.39105 -14.99707 8.10110  1.000 30.23868  ? 87  ALA A CA   1 
ATOM   1303 C C    . ALA A 1 90  ? 24.82837 -14.48330 8.09440  1.000 30.58719  ? 87  ALA A C    1 
ATOM   1304 O O    . ALA A 1 90  ? 25.25194 -13.80466 7.15083  1.000 30.86764  ? 87  ALA A O    1 
ATOM   1305 C CB   . ALA A 1 90  ? 22.49114 -14.07301 8.92220  1.000 35.98261  ? 87  ALA A CB   1 
ATOM   1306 H H    . ALA A 1 90  ? 22.85449 -16.43951 9.34536  1.000 35.86133  ? 87  ALA A H    1 
ATOM   1307 H HA   . ALA A 1 90  ? 23.06832 -14.99585 7.18636  1.000 36.30540  ? 87  ALA A HA   1 
ATOM   1308 H HB1  . ALA A 1 90  ? 22.54270 -13.17583 8.55710  1.000 43.19811  ? 87  ALA A HB1  1 
ATOM   1309 H HB2  . ALA A 1 90  ? 21.57823 -14.39744 8.87485  1.000 43.19811  ? 87  ALA A HB2  1 
ATOM   1310 H HB3  . ALA A 1 90  ? 22.79490 -14.07322 9.84341  1.000 43.19811  ? 87  ALA A HB3  1 
ATOM   1311 N N    . VAL A 1 91  ? 25.59894 -14.79698 9.13756  1.000 29.35799  ? 88  VAL A N    1 
ATOM   1312 C CA   . VAL A 1 91  ? 26.99419 -14.37285 9.16235  1.000 29.14480  ? 88  VAL A CA   1 
ATOM   1313 C C    . VAL A 1 91  ? 27.77178 -15.06938 8.05912  1.000 26.23291  ? 88  VAL A C    1 
ATOM   1314 O O    . VAL A 1 91  ? 28.61332 -14.45288 7.39141  1.000 26.68373  ? 88  VAL A O    1 
ATOM   1315 C CB   . VAL A 1 91  ? 27.61354 -14.64412 10.54382 1.000 27.40470  ? 88  VAL A CB   1 
ATOM   1316 C CG1  . VAL A 1 91  ? 29.10131 -14.33594 10.52461 1.000 29.66517  ? 88  VAL A CG1  1 
ATOM   1317 C CG2  . VAL A 1 91  ? 26.90296 -13.80964 11.61968 1.000 30.23610  ? 88  VAL A CG2  1 
ATOM   1318 H H    . VAL A 1 91  ? 25.34265 -15.24383 9.82621  1.000 35.24856  ? 88  VAL A H    1 
ATOM   1319 H HA   . VAL A 1 91  ? 27.02899 -13.41662 9.00324  1.000 34.99274  ? 88  VAL A HA   1 
ATOM   1320 H HB   . VAL A 1 91  ? 27.50079 -15.58214 10.76363 1.000 32.90462  ? 88  VAL A HB   1 
ATOM   1321 H HG11 . VAL A 1 91  ? 29.42961 -14.30692 11.43690 1.000 35.61719  ? 88  VAL A HG11 1 
ATOM   1322 H HG12 . VAL A 1 91  ? 29.56153 -15.03154 10.02940 1.000 35.61719  ? 88  VAL A HG12 1 
ATOM   1323 H HG13 . VAL A 1 91  ? 29.24041 -13.47719 10.09554 1.000 35.61719  ? 88  VAL A HG13 1 
ATOM   1324 H HG21 . VAL A 1 91  ? 27.31733 -13.98378 12.47925 1.000 36.30230  ? 88  VAL A HG21 1 
ATOM   1325 H HG22 . VAL A 1 91  ? 26.98672 -12.86939 11.39651 1.000 36.30230  ? 88  VAL A HG22 1 
ATOM   1326 H HG23 . VAL A 1 91  ? 25.96649 -14.06099 11.64693 1.000 36.30230  ? 88  VAL A HG23 1 
ATOM   1327 N N    . LYS A 1 92  ? 27.51029 -16.36751 7.85551  1.000 27.17620  ? 89  LYS A N    1 
ATOM   1328 C CA   . LYS A 1 92  ? 28.16832 -17.10163 6.77627  1.000 29.39787  ? 89  LYS A CA   1 
ATOM   1329 C C    . LYS A 1 92  ? 27.96844 -16.38989 5.44361  1.000 29.74548  ? 89  LYS A C    1 
ATOM   1330 O O    . LYS A 1 92  ? 28.92186 -16.16272 4.68793  1.000 28.35934  ? 89  LYS A O    1 
ATOM   1331 C CB   . LYS A 1 92  ? 27.62371 -18.53191 6.69727  1.000 30.72567  ? 89  LYS A CB   1 
ATOM   1332 C CG   . LYS A 1 92  ? 28.44208 -19.46898 5.80409  1.000 37.30585  ? 89  LYS A CG   1 
ATOM   1333 C CD   . LYS A 1 92  ? 27.76293 -20.83874 5.62120  1.000 46.09620  ? 89  LYS A CD   1 
ATOM   1334 C CE   . LYS A 1 92  ? 27.42923 -21.52180 6.95800  1.000 74.84765  ? 89  LYS A CE   1 
ATOM   1335 N NZ   . LYS A 1 92  ? 28.62638 -21.94738 7.75723  1.000 43.08108  ? 89  LYS A NZ   1 
ATOM   1336 H H    . LYS A 1 92  ? 26.96277 -16.83727 8.32363  1.000 32.63042  ? 89  LYS A H    1 
ATOM   1337 H HA   . LYS A 1 92  ? 29.11815 -17.15194 6.96651  1.000 35.29642  ? 89  LYS A HA   1 
ATOM   1338 H HB2  . LYS A 1 92  ? 27.61557 -18.91005 7.59049  1.000 36.88979  ? 89  LYS A HB2  1 
ATOM   1339 H HB3  . LYS A 1 92  ? 26.72165 -18.50071 6.34199  1.000 36.88979  ? 89  LYS A HB3  1 
ATOM   1340 H HG2  . LYS A 1 92  ? 28.54621 -19.06437 4.92868  1.000 44.78600  ? 89  LYS A HG2  1 
ATOM   1341 H HG3  . LYS A 1 92  ? 29.31195 -19.61482 6.20777  1.000 44.78600  ? 89  LYS A HG3  1 
ATOM   1342 H HD2  . LYS A 1 92  ? 26.93427 -20.71809 5.13164  1.000 55.33442  ? 89  LYS A HD2  1 
ATOM   1343 H HD3  . LYS A 1 92  ? 28.35829 -21.42347 5.12669  1.000 55.33442  ? 89  LYS A HD3  1 
ATOM   1344 H HE2  . LYS A 1 92  ? 26.91941 -20.90229 7.50315  1.000 89.83616  ? 89  LYS A HE2  1 
ATOM   1345 H HE3  . LYS A 1 92  ? 26.90201 -22.31556 6.77667  1.000 89.83616  ? 89  LYS A HE3  1 
ATOM   1346 H HZ1  . LYS A 1 92  ? 28.81970 -22.79906 7.58584  1.000 51.71628  ? 89  LYS A HZ1  1 
ATOM   1347 H HZ2  . LYS A 1 92  ? 28.45908 -21.85852 8.62683  1.000 51.71628  ? 89  LYS A HZ2  1 
ATOM   1348 H HZ3  . LYS A 1 92  ? 29.32870 -21.44348 7.54524  1.000 51.71628  ? 89  LYS A HZ3  1 
ATOM   1349 N N    . GLU A 1 93  ? 26.72232 -16.00821 5.15277  1.000 30.54056  ? 90  GLU A N    1 
ATOM   1350 C CA   . GLU A 1 93  ? 26.41593 -15.36808 3.87722  1.000 33.43022  ? 90  GLU A CA   1 
ATOM   1351 C C    . GLU A 1 93  ? 27.15958 -14.04527 3.75243  1.000 30.75425  ? 90  GLU A C    1 
ATOM   1352 O O    . GLU A 1 93  ? 27.75773 -13.74250 2.70862  1.000 30.88048  ? 90  GLU A O    1 
ATOM   1353 C CB   . GLU A 1 93  ? 24.90173 -15.16093 3.76027  1.000 38.39443  ? 90  GLU A CB   1 
ATOM   1354 C CG   . GLU A 1 93  ? 24.43905 -14.43327 2.51846  1.000 82.69278  ? 90  GLU A CG   1 
ATOM   1355 C CD   . GLU A 1 93  ? 22.92977 -14.22518 2.50784  1.000 95.65657  ? 90  GLU A CD   1 
ATOM   1356 O OE1  . GLU A 1 93  ? 22.23369 -14.88182 3.31906  1.000 71.75465  ? 90  GLU A OE1  1 
ATOM   1357 O OE2  . GLU A 1 93  ? 22.44345 -13.40329 1.69735  1.000 82.16210  ? 90  GLU A OE2  1 
ATOM   1358 H H    . GLU A 1 93  ? 26.04446 -16.10818 5.67249  1.000 36.66766  ? 90  GLU A H    1 
ATOM   1359 H HA   . GLU A 1 93  ? 26.69777 -15.94162 3.14749  1.000 40.13525  ? 90  GLU A HA   1 
ATOM   1360 H HB2  . GLU A 1 93  ? 24.47370 -16.03139 3.76128  1.000 46.09230  ? 90  GLU A HB2  1 
ATOM   1361 H HB3  . GLU A 1 93  ? 24.60445 -14.64416 4.52543  1.000 46.09230  ? 90  GLU A HB3  1 
ATOM   1362 H HG2  . GLU A 1 93  ? 24.86535 -13.56276 2.48136  1.000 99.25032  ? 90  GLU A HG2  1 
ATOM   1363 H HG3  . GLU A 1 93  ? 24.67881 -14.95372 1.73580  1.000 99.25032  ? 90  GLU A HG3  1 
ATOM   1364 N N    . ILE A 1 94  ? 27.13953 -13.24275 4.81880  1.000 31.12607  ? 91  ILE A N    1 
ATOM   1365 C CA   . ILE A 1 94  ? 27.81359 -11.94536 4.78031  1.000 30.12422  ? 91  ILE A CA   1 
ATOM   1366 C C    . ILE A 1 94  ? 29.30560 -12.12791 4.53390  1.000 28.19574  ? 91  ILE A C    1 
ATOM   1367 O O    . ILE A 1 94  ? 29.91191 -11.41693 3.72200  1.000 27.39235  ? 91  ILE A O    1 
ATOM   1368 C CB   . ILE A 1 94  ? 27.55941 -11.15565 6.07930  1.000 33.04210  ? 91  ILE A CB   1 
ATOM   1369 C CG1  . ILE A 1 94  ? 26.11283 -10.66812 6.13004  1.000 39.90756  ? 91  ILE A CG1  1 
ATOM   1370 C CG2  . ILE A 1 94  ? 28.52208 -9.98811  6.18965  1.000 31.62197  ? 91  ILE A CG2  1 
ATOM   1371 C CD1  . ILE A 1 94  ? 25.68196 -10.15377 7.48463  1.000 47.41674  ? 91  ILE A CD1  1 
ATOM   1372 H H    . ILE A 1 94  ? 26.74944 -13.42296 5.56375  1.000 37.37026  ? 91  ILE A H    1 
ATOM   1373 H HA   . ILE A 1 94  ? 27.44213 -11.43718 4.04229  1.000 36.16804  ? 91  ILE A HA   1 
ATOM   1374 H HB   . ILE A 1 94  ? 27.71039 -11.74843 6.83211  1.000 39.66950  ? 91  ILE A HB   1 
ATOM   1375 H HG12 . ILE A 1 94  ? 26.00641 -9.94465  5.49273  1.000 47.90805  ? 91  ILE A HG12 1 
ATOM   1376 H HG13 . ILE A 1 94  ? 25.52814 -11.40566 5.89537  1.000 47.90805  ? 91  ILE A HG13 1 
ATOM   1377 H HG21 . ILE A 1 94  ? 28.17110 -9.34876  6.82914  1.000 37.96535  ? 91  ILE A HG21 1 
ATOM   1378 H HG22 . ILE A 1 94  ? 29.38403 -10.31676 6.48955  1.000 37.96535  ? 91  ILE A HG22 1 
ATOM   1379 H HG23 . ILE A 1 94  ? 28.61223 -9.56977  5.31915  1.000 37.96535  ? 91  ILE A HG23 1 
ATOM   1380 H HD11 . ILE A 1 94  ? 24.72037 -10.02630 7.48278  1.000 56.91907  ? 91  ILE A HD11 1 
ATOM   1381 H HD12 . ILE A 1 94  ? 25.92826 -10.80300 8.16192  1.000 56.91907  ? 91  ILE A HD12 1 
ATOM   1382 H HD13 . ILE A 1 94  ? 26.12719 -9.30964  7.65815  1.000 56.91907  ? 91  ILE A HD13 1 
ATOM   1383 N N    . LEU A 1 95  ? 29.92623 -13.06505 5.25309  1.000 27.08258  ? 92  LEU A N    1 
ATOM   1384 C CA   . LEU A 1 95  ? 31.36926 -13.23653 5.13552  1.000 27.41621  ? 92  LEU A CA   1 
ATOM   1385 C C    . LEU A 1 95  ? 31.75093 -13.77043 3.76017  1.000 28.30086  ? 92  LEU A C    1 
ATOM   1386 O O    . LEU A 1 95  ? 32.70915 -13.28625 3.14576  1.000 27.48489  ? 92  LEU A O    1 
ATOM   1387 C CB   . LEU A 1 95  ? 31.87493 -14.16734 6.23570  1.000 26.44321  ? 92  LEU A CB   1 
ATOM   1388 C CG   . LEU A 1 95  ? 31.77045 -13.61515 7.66839  1.000 27.52272  ? 92  LEU A CG   1 
ATOM   1389 C CD1  . LEU A 1 95  ? 32.23071 -14.65497 8.66882  1.000 25.17070  ? 92  LEU A CD1  1 
ATOM   1390 C CD2  . LEU A 1 95  ? 32.56370 -12.33810 7.81549  1.000 28.79672  ? 92  LEU A CD2  1 
ATOM   1391 H H    A LEU A 1 95  ? 29.54147 -13.60193 5.80384  0.650 32.51807  ? 92  LEU A H    1 
ATOM   1392 H H    B LEU A 1 95  ? 29.54147 -13.60193 5.80384  0.350 32.51807  ? 92  LEU A H    1 
ATOM   1393 H HA   . LEU A 1 95  ? 31.79899 -12.37463 5.25113  1.000 32.91843  ? 92  LEU A HA   1 
ATOM   1394 H HB2  . LEU A 1 95  ? 31.35748 -14.98713 6.20282  1.000 31.75084  ? 92  LEU A HB2  1 
ATOM   1395 H HB3  . LEU A 1 95  ? 32.81071 -14.35868 6.06658  1.000 31.75084  ? 92  LEU A HB3  1 
ATOM   1396 H HG   . LEU A 1 95  ? 30.84254 -13.40469 7.85705  1.000 33.04624  ? 92  LEU A HG   1 
ATOM   1397 H HD11 . LEU A 1 95  ? 32.14858 -14.29018 9.56385  1.000 30.22382  ? 92  LEU A HD11 1 
ATOM   1398 H HD12 . LEU A 1 95  ? 31.67489 -15.44511 8.58137  1.000 30.22382  ? 92  LEU A HD12 1 
ATOM   1399 H HD13 . LEU A 1 95  ? 33.15655 -14.88005 8.48703  1.000 30.22382  ? 92  LEU A HD13 1 
ATOM   1400 H HD21 . LEU A 1 95  ? 32.61646 -12.10564 8.75575  1.000 34.57505  ? 92  LEU A HD21 1 
ATOM   1401 H HD22 . LEU A 1 95  ? 33.45490 -12.47703 7.45859  1.000 34.57505  ? 92  LEU A HD22 1 
ATOM   1402 H HD23 . LEU A 1 95  ? 32.11728 -11.63069 7.32440  1.000 34.57505  ? 92  LEU A HD23 1 
ATOM   1403 N N    A LYS A 1 96  ? 31.01678 -14.76932 3.26279  0.467 29.59851  ? 93  LYS A N    1 
ATOM   1404 N N    B LYS A 1 96  ? 31.02530 -14.77728 3.26385  0.533 29.59035  ? 93  LYS A N    1 
ATOM   1405 C CA   A LYS A 1 96  ? 31.31784 -15.31405 1.94244  0.467 31.37164  ? 93  LYS A CA   1 
ATOM   1406 C CA   B LYS A 1 96  ? 31.32960 -15.31126 1.93899  0.533 31.31243  ? 93  LYS A CA   1 
ATOM   1407 C C    A LYS A 1 96  ? 31.16990 -14.24730 0.86633  0.467 32.42383  ? 93  LYS A C    1 
ATOM   1408 C C    B LYS A 1 96  ? 31.18478 -14.23176 0.87467  0.533 32.32575  ? 93  LYS A C    1 
ATOM   1409 O O    A LYS A 1 96  ? 32.00586 -14.14848 -0.03802 0.467 33.43500  ? 93  LYS A O    1 
ATOM   1410 O O    B LYS A 1 96  ? 32.03705 -14.10499 -0.01120 0.533 33.16985  ? 93  LYS A O    1 
ATOM   1411 C CB   A LYS A 1 96  ? 30.41876 -16.51584 1.64571  0.467 33.51437  ? 93  LYS A CB   1 
ATOM   1412 C CB   B LYS A 1 96  ? 30.43027 -16.50826 1.62100  0.533 33.48801  ? 93  LYS A CB   1 
ATOM   1413 C CG   A LYS A 1 96  ? 30.75708 -17.75016 2.47529  0.467 36.61285  ? 93  LYS A CG   1 
ATOM   1414 C CG   B LYS A 1 96  ? 30.98043 -17.85378 2.10314  0.533 36.84462  ? 93  LYS A CG   1 
ATOM   1415 C CD   A LYS A 1 96  ? 30.02616 -18.99130 1.97841  0.467 42.36925  ? 93  LYS A CD   1 
ATOM   1416 C CD   B LYS A 1 96  ? 32.25843 -18.24480 1.36272  0.533 46.86916  ? 93  LYS A CD   1 
ATOM   1417 C CE   A LYS A 1 96  ? 30.43297 -20.23292 2.77383  0.467 40.34261  ? 93  LYS A CE   1 
ATOM   1418 C CE   B LYS A 1 96  ? 32.88436 -19.51808 1.94065  0.533 40.17976  ? 93  LYS A CE   1 
ATOM   1419 N NZ   A LYS A 1 96  ? 31.87571 -20.57965 2.59771  0.467 38.97306  ? 93  LYS A NZ   1 
ATOM   1420 N NZ   B LYS A 1 96  ? 34.29916 -19.70748 1.48438  0.533 36.84214  ? 93  LYS A NZ   1 
ATOM   1421 H H    A LYS A 1 96  ? 30.35243 -15.14085 3.66305  0.467 35.53720  ? 93  LYS A H    1 
ATOM   1422 H H    B LYS A 1 96  ? 30.36756 -15.15859 3.66581  0.533 35.52740  ? 93  LYS A H    1 
ATOM   1423 H HA   A LYS A 1 96  ? 32.23617 -15.62627 1.93317  0.467 37.66495  ? 93  LYS A HA   1 
ATOM   1424 H HA   B LYS A 1 96  ? 32.24667 -15.62726 1.93292  0.533 37.59390  ? 93  LYS A HA   1 
ATOM   1425 H HB2  A LYS A 1 96  ? 29.49924 -16.27284 1.83634  0.467 40.23623  ? 93  LYS A HB2  1 
ATOM   1426 H HB2  B LYS A 1 96  ? 29.57029 -16.37199 2.04851  0.533 40.20460  ? 93  LYS A HB2  1 
ATOM   1427 H HB3  A LYS A 1 96  ? 30.51215 -16.75244 0.70966  0.467 40.23623  ? 93  LYS A HB3  1 
ATOM   1428 H HB3  B LYS A 1 96  ? 30.31748 -16.56430 0.65921  0.533 40.20460  ? 93  LYS A HB3  1 
ATOM   1429 H HG2  A LYS A 1 96  ? 31.71078 -17.91906 2.42191  0.467 43.95440  ? 93  LYS A HG2  1 
ATOM   1430 H HG2  B LYS A 1 96  ? 31.18420 -17.79533 3.04969  0.533 44.23253  ? 93  LYS A HG2  1 
ATOM   1431 H HG3  A LYS A 1 96  ? 30.49861 -17.59571 3.39737  0.467 43.95440  ? 93  LYS A HG3  1 
ATOM   1432 H HG3  B LYS A 1 96  ? 30.31709 -18.54443 1.94861  0.533 44.23253  ? 93  LYS A HG3  1 
ATOM   1433 H HD2  A LYS A 1 96  ? 29.06989 -18.86366 2.07924  0.467 50.86208  ? 93  LYS A HD2  1 
ATOM   1434 H HD2  B LYS A 1 96  ? 32.05094 -18.40548 0.42890  0.533 56.26197  ? 93  LYS A HD2  1 
ATOM   1435 H HD3  A LYS A 1 96  ? 30.24426 -19.14130 1.04522  0.467 50.86208  ? 93  LYS A HD3  1 
ATOM   1436 H HD3  B LYS A 1 96  ? 32.90564 -17.52643 1.43992  0.533 56.26197  ? 93  LYS A HD3  1 
ATOM   1437 H HE2  A LYS A 1 96  ? 30.27590 -20.07062 3.71717  0.467 48.43011  ? 93  LYS A HE2  1 
ATOM   1438 H HE2  B LYS A 1 96  ? 32.88360 -19.46260 2.90906  0.533 48.23470  ? 93  LYS A HE2  1 
ATOM   1439 H HE3  A LYS A 1 96  ? 29.90359 -20.98864 2.47458  0.467 48.43011  ? 93  LYS A HE3  1 
ATOM   1440 H HE3  B LYS A 1 96  ? 32.36786 -20.28671 1.65197  0.533 48.23470  ? 93  LYS A HE3  1 
ATOM   1441 H HZ1  A LYS A 1 96  ? 32.38697 -19.91113 2.88718  0.467 46.78666  ? 93  LYS A HZ1  1 
ATOM   1442 H HZ1  B LYS A 1 96  ? 34.32809 -19.76075 0.59644  0.533 44.22955  ? 93  LYS A HZ1  1 
ATOM   1443 H HZ2  A LYS A 1 96  ? 32.05087 -20.72562 1.73742  0.467 46.78666  ? 93  LYS A HZ2  1 
ATOM   1444 H HZ2  B LYS A 1 96  ? 34.79890 -19.02019 1.74893  0.533 44.22955  ? 93  LYS A HZ2  1 
ATOM   1445 H HZ3  A LYS A 1 96  ? 32.07101 -21.31410 3.06090  0.467 46.78666  ? 93  LYS A HZ3  1 
ATOM   1446 H HZ3  B LYS A 1 96  ? 34.63262 -20.45691 1.82971  0.533 44.22955  ? 93  LYS A HZ3  1 
ATOM   1447 N N    . GLU A 1 97  ? 30.12568 -13.42366 0.95898  1.000 30.14847  ? 94  GLU A N    1 
ATOM   1448 C CA   . GLU A 1 97  ? 29.96931 -12.32926 0.00880  1.000 33.56870  ? 94  GLU A CA   1 
ATOM   1449 C C    . GLU A 1 97  ? 31.13752 -11.35862 0.10427  1.000 34.89047  ? 94  GLU A C    1 
ATOM   1450 O O    . GLU A 1 97  ? 31.66915 -10.90976 -0.91887 1.000 33.29928  ? 94  GLU A O    1 
ATOM   1451 C CB   . GLU A 1 97  ? 28.65113 -11.59871 0.25973  1.000 36.04032  ? 94  GLU A CB   1 
ATOM   1452 C CG   . GLU A 1 97  ? 28.49404 -10.30502 -0.52785 1.000 55.23359  ? 94  GLU A CG   1 
ATOM   1453 C CD   . GLU A 1 97  ? 27.27407 -9.49577  -0.08694 1.000 82.82074  ? 94  GLU A CD   1 
ATOM   1454 O OE1  . GLU A 1 97  ? 26.36239 -10.08267 0.54195  1.000 74.19799  ? 94  GLU A OE1  1 
ATOM   1455 O OE2  . GLU A 1 97  ? 27.23306 -8.27462  -0.36237 1.000 82.79853  ? 94  GLU A OE2  1 
ATOM   1456 H H    A GLU A 1 97  ? 29.50562 -13.47702 1.55251  0.467 36.19715  ? 94  GLU A H    1 
ATOM   1457 H H    B GLU A 1 97  ? 29.49899 -13.48797 1.54440  0.533 36.19715  ? 94  GLU A H    1 
ATOM   1458 H HA   . GLU A 1 97  ? 29.94425 -12.69398 -0.88968 1.000 40.30143  ? 94  GLU A HA   1 
ATOM   1459 H HB2  . GLU A 1 97  ? 27.91953 -12.18511 0.01113  1.000 43.26736  ? 94  GLU A HB2  1 
ATOM   1460 H HB3  . GLU A 1 97  ? 28.59367 -11.37794 1.20253  1.000 43.26736  ? 94  GLU A HB3  1 
ATOM   1461 H HG2  . GLU A 1 97  ? 29.28288 -9.75606  -0.39644 1.000 66.29929  ? 94  GLU A HG2  1 
ATOM   1462 H HG3  . GLU A 1 97  ? 28.39048 -10.51719 -1.46868 1.000 66.29929  ? 94  GLU A HG3  1 
ATOM   1463 N N    . GLN A 1 98  ? 31.53876 -11.00585 1.32889  1.000 30.13645  ? 95  GLN A N    1 
ATOM   1464 C CA   . GLN A 1 98  ? 32.64802 -10.07104 1.50099  1.000 30.51795  ? 95  GLN A CA   1 
ATOM   1465 C C    . GLN A 1 98  ? 33.94526 -10.65416 0.94920  1.000 30.73081  ? 95  GLN A C    1 
ATOM   1466 O O    . GLN A 1 98  ? 34.73098 -9.94907  0.29849  1.000 28.95122  ? 95  GLN A O    1 
ATOM   1467 C CB   . GLN A 1 98  ? 32.80120 -9.71376  2.98247  1.000 29.54457  ? 95  GLN A CB   1 
ATOM   1468 C CG   . GLN A 1 98  ? 33.85880 -8.64973  3.26508  1.000 26.93247  ? 95  GLN A CG   1 
ATOM   1469 C CD   . GLN A 1 98  ? 33.38939 -7.23970  2.96648  1.000 31.10012  ? 95  GLN A CD   1 
ATOM   1470 O OE1  . GLN A 1 98  ? 32.38806 -7.03222  2.28545  1.000 33.44883  ? 95  GLN A OE1  1 
ATOM   1471 N NE2  . GLN A 1 98  ? 34.11448 -6.26033  3.48536  1.000 28.35861  ? 95  GLN A NE2  1 
ATOM   1472 H H    . GLN A 1 98  ? 31.19080 -11.28916 2.06256  1.000 36.18272  ? 95  GLN A H    1 
ATOM   1473 H HA   . GLN A 1 98  ? 32.45518 -9.25477  1.01374  1.000 36.64053  ? 95  GLN A HA   1 
ATOM   1474 H HB2  . GLN A 1 98  ? 31.95191 -9.37831  3.30969  1.000 35.47247  ? 95  GLN A HB2  1 
ATOM   1475 H HB3  . GLN A 1 98  ? 33.05179 -10.51409 3.46989  1.000 35.47247  ? 95  GLN A HB3  1 
ATOM   1476 H HG2  . GLN A 1 98  ? 34.10100 -8.68981  4.20350  1.000 32.33794  ? 95  GLN A HG2  1 
ATOM   1477 H HG3  . GLN A 1 98  ? 34.63698 -8.82687  2.71375  1.000 32.33794  ? 95  GLN A HG3  1 
ATOM   1478 H HE21 . GLN A 1 98  ? 34.80732 -6.44364  3.96074  1.000 34.04932  ? 95  GLN A HE21 1 
ATOM   1479 H HE22 . GLN A 1 98  ? 33.89247 -5.44110  3.34692  1.000 34.04932  ? 95  GLN A HE22 1 
ATOM   1480 N N    . GLU A 1 99  ? 34.18625 -11.94362 1.19801  1.000 29.30167  ? 96  GLU A N    1 
ATOM   1481 C CA   . GLU A 1 99  ? 35.37057 -12.58780 0.63870  1.000 33.15192  ? 96  GLU A CA   1 
ATOM   1482 C C    . GLU A 1 99  ? 35.36298 -12.52610 -0.88700 1.000 34.13606  ? 96  GLU A C    1 
ATOM   1483 O O    . GLU A 1 99  ? 36.38522 -12.20942 -1.50881 1.000 34.37960  ? 96  GLU A O    1 
ATOM   1484 C CB   . GLU A 1 99  ? 35.45097 -14.03811 1.11796  1.000 34.42156  ? 96  GLU A CB   1 
ATOM   1485 C CG   . GLU A 1 99  ? 36.77606 -14.72765 0.80972  1.000 38.90975  ? 96  GLU A CG   1 
ATOM   1486 C CD   . GLU A 1 99  ? 36.81847 -16.15767 1.31710  1.000 36.53992  ? 96  GLU A CD   1 
ATOM   1487 O OE1  . GLU A 1 99  ? 35.78365 -16.85770 1.24596  1.000 38.77598  ? 96  GLU A OE1  1 
ATOM   1488 O OE2  . GLU A 1 99  ? 37.88840 -16.57152 1.79266  1.000 39.48469  ? 96  GLU A OE2  1 
ATOM   1489 H H    . GLU A 1 99  ? 33.68916 -12.45584 1.67774  1.000 35.18098  ? 96  GLU A H    1 
ATOM   1490 H HA   . GLU A 1 99  ? 36.16079 -12.12198 0.95408  1.000 39.80129  ? 96  GLU A HA   1 
ATOM   1491 H HB2  . GLU A 1 99  ? 35.32828 -14.05372 2.08004  1.000 41.32485  ? 96  GLU A HB2  1 
ATOM   1492 H HB3  . GLU A 1 99  ? 34.74731 -14.54677 0.68548  1.000 41.32485  ? 96  GLU A HB3  1 
ATOM   1493 H HG2  . GLU A 1 99  ? 36.90851 -14.74505 -0.15104 1.000 46.71068  ? 96  GLU A HG2  1 
ATOM   1494 H HG3  . GLU A 1 99  ? 37.49590 -14.23585 1.23500  1.000 46.71068  ? 96  GLU A HG3  1 
ATOM   1495 N N    . ASN A 1 100 ? 34.21004 -12.79759 -1.50697 1.000 35.84934  ? 97  ASN A N    1 
ATOM   1496 C CA   . ASN A 1 100 ? 34.15797 -12.86553 -2.96386 1.000 39.69607  ? 97  ASN A CA   1 
ATOM   1497 C C    . ASN A 1 100 ? 34.42559 -11.50755 -3.59464 1.000 43.41479  ? 97  ASN A C    1 
ATOM   1498 O O    . ASN A 1 100 ? 35.08289 -11.42480 -4.63874 1.000 46.01460  ? 97  ASN A O    1 
ATOM   1499 C CB   . ASN A 1 100 ? 32.80453 -13.40574 -3.42234 1.000 43.96987  ? 97  ASN A CB   1 
ATOM   1500 C CG   . ASN A 1 100 ? 32.67387 -14.90365 -3.20618 1.000 67.44270  ? 97  ASN A CG   1 
ATOM   1501 O OD1  . ASN A 1 100 ? 33.67270 -15.62611 -3.15729 1.000 72.53357  ? 97  ASN A OD1  1 
ATOM   1502 N ND2  . ASN A 1 100 ? 31.44097 -15.37784 -3.07349 1.000 66.04564  ? 97  ASN A ND2  1 
ATOM   1503 H H    . ASN A 1 100 ? 33.45977 -12.94318 -1.11264 1.000 43.03820  ? 97  ASN A H    1 
ATOM   1504 H HA   . ASN A 1 100 ? 34.84545 -13.47977 -3.26549 1.000 47.65427  ? 97  ASN A HA   1 
ATOM   1505 H HB2  . ASN A 1 100 ? 32.10084 -12.96641 -2.91963 1.000 52.78283  ? 97  ASN A HB2  1 
ATOM   1506 H HB3  . ASN A 1 100 ? 32.69629 -13.22761 -4.36968 1.000 52.78283  ? 97  ASN A HB3  1 
ATOM   1507 H HD21 . ASN A 1 100 ? 31.31501 -16.21944 -2.94921 1.000 79.27374  ? 97  ASN A HD21 1 
ATOM   1508 H HD22 . ASN A 1 100 ? 30.76828 -14.84342 -3.11182 1.000 79.27374  ? 97  ASN A HD22 1 
ATOM   1509 N N    . ARG A 1 101 ? 33.92157 -10.43330 -2.98875 1.000 36.75723  ? 98  ARG A N    1 
ATOM   1510 C CA   . ARG A 1 101 ? 34.14937 -9.09219  -3.50805 1.000 36.94767  ? 98  ARG A CA   1 
ATOM   1511 C C    . ARG A 1 101 ? 35.45893 -8.49190  -3.01497 1.000 36.59293  ? 98  ARG A C    1 
ATOM   1512 O O    . ARG A 1 101 ? 35.72320 -7.31053  -3.26761 1.000 40.91723  ? 98  ARG A O    1 
ATOM   1513 C CB   . ARG A 1 101 ? 32.98002 -8.16861  -3.16037 1.000 45.34087  ? 98  ARG A CB   1 
ATOM   1514 C CG   . ARG A 1 101 ? 32.70920 -7.98253  -1.69618 1.000 59.11347  ? 98  ARG A CG   1 
ATOM   1515 C CD   . ARG A 1 101 ? 31.54021 -7.01164  -1.49091 1.000 56.49128  ? 98  ARG A CD   1 
ATOM   1516 N NE   . ARG A 1 101 ? 31.84943 -5.69247  -2.03071 1.000 63.13730  ? 98  ARG A NE   1 
ATOM   1517 C CZ   . ARG A 1 101 ? 32.51293 -4.75255  -1.36961 1.000 79.90860  ? 98  ARG A CZ   1 
ATOM   1518 N NH1  . ARG A 1 101 ? 32.92796 -4.94311  -0.12433 1.000 50.22087  ? 98  ARG A NH1  1 
ATOM   1519 N NH2  . ARG A 1 101 ? 32.76839 -3.59291  -1.97154 1.000 69.90577  ? 98  ARG A NH2  1 
ATOM   1520 H H    A ARG A 1 101 ? 33.44381 -10.45909 -2.27413 0.410 44.12766  ? 98  ARG A H    1 
ATOM   1521 H H    B ARG A 1 101 ? 33.44381 -10.45909 -2.27413 0.590 44.12766  ? 98  ARG A H    1 
ATOM   1522 H HA   . ARG A 1 101 ? 34.19069 -9.14365  -4.47580 1.000 44.35618  ? 98  ARG A HA   1 
ATOM   1523 H HB2  . ARG A 1 101 ? 33.16398 -7.29192  -3.53250 1.000 54.42802  ? 98  ARG A HB2  1 
ATOM   1524 H HB3  . ARG A 1 101 ? 32.17455 -8.53523  -3.55750 1.000 54.42802  ? 98  ARG A HB3  1 
ATOM   1525 H HG2  . ARG A 1 101 ? 32.47751 -8.83550  -1.29661 1.000 70.95515  ? 98  ARG A HG2  1 
ATOM   1526 H HG3  . ARG A 1 101 ? 33.49608 -7.61615  -1.26318 1.000 70.95515  ? 98  ARG A HG3  1 
ATOM   1527 H HD2  . ARG A 1 101 ? 30.75445 -7.35248  -1.94622 1.000 67.80852  ? 98  ARG A HD2  1 
ATOM   1528 H HD3  . ARG A 1 101 ? 31.36023 -6.91995  -0.54217 1.000 67.80852  ? 98  ARG A HD3  1 
ATOM   1529 H HE   . ARG A 1 101 ? 31.58470 -5.51220  -2.82885 1.000 75.78374  ? 98  ARG A HE   1 
ATOM   1530 H HH11 . ARG A 1 101 ? 32.76854 -5.68916  0.27265  1.000 60.28402  ? 98  ARG A HH11 1 
ATOM   1531 H HH12 . ARG A 1 101 ? 33.35647 -4.32060  0.28612  1.000 60.28402  ? 98  ARG A HH12 1 
ATOM   1532 H HH21 . ARG A 1 101 ? 32.50416 -3.46024  -2.77911 1.000 83.90591  ? 98  ARG A HH21 1 
ATOM   1533 H HH22 . ARG A 1 101 ? 33.19764 -2.97647  -1.55280 1.000 83.90591  ? 98  ARG A HH22 1 
ATOM   1534 N N    . LYS A 1 102 ? 36.28220 -9.27851  -2.32098 1.000 37.36269  ? 99  LYS A N    1 
ATOM   1535 C CA   . LYS A 1 102 ? 37.61006 -8.84063  -1.89187 1.000 40.90484  ? 99  LYS A CA   1 
ATOM   1536 C C    . LYS A 1 102 ? 37.52417 -7.63680  -0.95712 1.000 35.68035  ? 99  LYS A C    1 
ATOM   1537 O O    . LYS A 1 102 ? 38.34431 -6.71736  -1.01185 1.000 37.50154  ? 99  LYS A O    1 
ATOM   1538 C CB   . LYS A 1 102 ? 38.49261 -8.54636  -3.10467 1.000 46.28297  ? 99  LYS A CB   1 
ATOM   1539 C CG   . LYS A 1 102 ? 38.75164 -9.79676  -3.95474 1.000 57.53363  ? 99  LYS A CG   1 
ATOM   1540 C CD   . LYS A 1 102 ? 39.25474 -9.45048  -5.34568 1.000 86.93876  ? 99  LYS A CD   1 
ATOM   1541 C CE   . LYS A 1 102 ? 40.77161 -9.33513  -5.39092 1.000 79.85931  ? 99  LYS A CE   1 
ATOM   1542 N NZ   . LYS A 1 102 ? 41.23208 -8.80681  -6.71196 1.000 106.81270 ? 99  LYS A NZ   1 
ATOM   1543 H H    . LYS A 1 102 ? 36.09127 -10.08256 -2.08296 1.000 44.85421  ? 99  LYS A H    1 
ATOM   1544 H HA   . LYS A 1 102 ? 38.02749 -9.55424  -1.38451 1.000 49.10479  ? 99  LYS A HA   1 
ATOM   1545 H HB2  . LYS A 1 102 ? 38.05354 -7.88650  -3.66388 1.000 55.55854  ? 99  LYS A HB2  1 
ATOM   1546 H HB3  . LYS A 1 102 ? 39.34811 -8.20606  -2.79936 1.000 55.55854  ? 99  LYS A HB3  1 
ATOM   1547 H HG2  . LYS A 1 102 ? 39.42254 -10.34515 -3.51879 1.000 69.05934  ? 99  LYS A HG2  1 
ATOM   1548 H HG3  . LYS A 1 102 ? 37.92495 -10.29553 -4.04812 1.000 69.05934  ? 99  LYS A HG3  1 
ATOM   1549 H HD2  . LYS A 1 102 ? 38.98545 -10.14658 -5.96522 1.000 104.34549 ? 99  LYS A HD2  1 
ATOM   1550 H HD3  . LYS A 1 102 ? 38.87812 -8.59935  -5.61886 1.000 104.34549 ? 99  LYS A HD3  1 
ATOM   1551 H HE2  . LYS A 1 102 ? 41.06982 -8.72701  -4.69655 1.000 95.85015  ? 99  LYS A HE2  1 
ATOM   1552 H HE3  . LYS A 1 102 ? 41.16597 -10.21111 -5.25657 1.000 95.85015  ? 99  LYS A HE3  1 
ATOM   1553 H HZ1  . LYS A 1 102 ? 42.12150 -8.79549  -6.74199 1.000 128.19422 ? 99  LYS A HZ1  1 
ATOM   1554 H HZ2  . LYS A 1 102 ? 40.92743 -9.32359  -7.36940 1.000 128.19422 ? 99  LYS A HZ2  1 
ATOM   1555 H HZ3  . LYS A 1 102 ? 40.92849 -7.97873  -6.83118 1.000 128.19422 ? 99  LYS A HZ3  1 
ATOM   1556 N N    . GLY A 1 103 ? 36.52762 -7.65511  -0.07664 1.000 32.42035  ? 100 GLY A N    1 
ATOM   1557 C CA   . GLY A 1 103 ? 36.44878 -6.66995  0.97420  1.000 31.31102  ? 100 GLY A CA   1 
ATOM   1558 C C    . GLY A 1 103 ? 37.19721 -7.12403  2.22000  1.000 29.29591  ? 100 GLY A C    1 
ATOM   1559 O O    . GLY A 1 103 ? 37.48855 -8.29968  2.39114  1.000 30.09906  ? 100 GLY A O    1 
ATOM   1560 H H    . GLY A 1 103 ? 35.88867 -8.23073  -0.07288 1.000 38.92341  ? 100 GLY A H    1 
ATOM   1561 H HA2  . GLY A 1 103 ? 36.83642 -5.83563  0.66670  1.000 37.59220  ? 100 GLY A HA2  1 
ATOM   1562 H HA3  . GLY A 1 103 ? 35.51971 -6.51905  1.20863  1.000 37.59220  ? 100 GLY A HA3  1 
ATOM   1563 N N    . LEU A 1 104 ? 37.50575 -6.16577  3.08932  1.000 26.58269  ? 101 LEU A N    1 
ATOM   1564 C CA   . LEU A 1 104 ? 38.25604 -6.46209  4.29971  1.000 27.92486  ? 101 LEU A CA   1 
ATOM   1565 C C    . LEU A 1 104 ? 37.37451 -7.17885  5.31505  1.000 25.78378  ? 101 LEU A C    1 
ATOM   1566 O O    . LEU A 1 104 ? 36.19207 -6.85841  5.48397  1.000 24.81005  ? 101 LEU A O    1 
ATOM   1567 C CB   . LEU A 1 104 ? 38.80472 -5.17061  4.89621  1.000 28.61680  ? 101 LEU A CB   1 
ATOM   1568 C CG   . LEU A 1 104 ? 39.74495 -5.27380  6.08389  1.000 34.52283  ? 101 LEU A CG   1 
ATOM   1569 C CD1  . LEU A 1 104 ? 40.93871 -6.12979  5.73406  1.000 32.71861  ? 101 LEU A CD1  1 
ATOM   1570 C CD2  . LEU A 1 104 ? 40.17989 -3.87497  6.51332  1.000 32.86644  ? 101 LEU A CD2  1 
ATOM   1571 H H    . LEU A 1 104 ? 37.29177 -5.33763  2.99994  1.000 31.91821  ? 101 LEU A H    1 
ATOM   1572 H HA   . LEU A 1 104 ? 39.00248 -7.04428  4.08809  1.000 33.52882  ? 101 LEU A HA   1 
ATOM   1573 H HB2  . LEU A 1 104 ? 39.29060 -4.70671  4.19648  1.000 34.35914  ? 101 LEU A HB2  1 
ATOM   1574 H HB3  . LEU A 1 104 ? 38.04885 -4.63603  5.18565  1.000 34.35914  ? 101 LEU A HB3  1 
ATOM   1575 H HG   . LEU A 1 104 ? 39.29135 -5.69536  6.83052  1.000 41.44638  ? 101 LEU A HG   1 
ATOM   1576 H HD11 . LEU A 1 104 ? 41.61417 -6.02623  6.42249  1.000 39.28131  ? 101 LEU A HD11 1 
ATOM   1577 H HD12 . LEU A 1 104 ? 40.65828 -7.05694  5.68261  1.000 39.28131  ? 101 LEU A HD12 1 
ATOM   1578 H HD13 . LEU A 1 104 ? 41.29265 -5.84324  4.87761  1.000 39.28131  ? 101 LEU A HD13 1 
ATOM   1579 H HD21 . LEU A 1 104 ? 40.71739 -3.94443  7.31779  1.000 39.45871  ? 101 LEU A HD21 1 
ATOM   1580 H HD22 . LEU A 1 104 ? 40.70143 -3.47372  5.80065  1.000 39.45871  ? 101 LEU A HD22 1 
ATOM   1581 H HD23 . LEU A 1 104 ? 39.39078 -3.33861  6.68803  1.000 39.45871  ? 101 LEU A HD23 1 
ATOM   1582 N N    . ILE A 1 105 ? 37.96180 -8.16712  5.98122  1.000 25.51851  ? 102 ILE A N    1 
ATOM   1583 C CA   . ILE A 1 105 ? 37.33630 -8.88501  7.08627  1.000 25.33176  ? 102 ILE A CA   1 
ATOM   1584 C C    . ILE A 1 105 ? 38.26584 -8.78366  8.28725  1.000 25.32526  ? 102 ILE A C    1 
ATOM   1585 O O    . ILE A 1 105 ? 39.44699 -9.13469  8.18980  1.000 22.91012  ? 102 ILE A O    1 
ATOM   1586 C CB   . ILE A 1 105 ? 37.06725 -10.35837 6.73366  1.000 26.93229  ? 102 ILE A CB   1 
ATOM   1587 C CG1  . ILE A 1 105 ? 36.05462 -10.44783 5.58679  1.000 29.38437  ? 102 ILE A CG1  1 
ATOM   1588 C CG2  . ILE A 1 105 ? 36.56309 -11.10862 7.95342  1.000 26.58488  ? 102 ILE A CG2  1 
ATOM   1589 C CD1  . ILE A 1 105 ? 35.87237 -11.86123 5.04004  1.000 35.93349  ? 102 ILE A CD1  1 
ATOM   1590 H H    . ILE A 1 105 ? 38.75414 -8.45076  5.80414  1.000 30.64119  ? 102 ILE A H    1 
ATOM   1591 H HA   . ILE A 1 105 ? 36.48860 -8.46745  7.30520  1.000 30.41710  ? 102 ILE A HA   1 
ATOM   1592 H HB   . ILE A 1 105 ? 37.89840 -10.76653 6.44469  1.000 32.33772  ? 102 ILE A HB   1 
ATOM   1593 H HG12 . ILE A 1 105 ? 35.19219 -10.14020 5.90692  1.000 35.28023  ? 102 ILE A HG12 1 
ATOM   1594 H HG13 . ILE A 1 105 ? 36.35800 -9.88463  4.85763  1.000 35.28023  ? 102 ILE A HG13 1 
ATOM   1595 H HG21 . ILE A 1 105 ? 36.26146 -11.98912 7.68023  1.000 31.92084  ? 102 ILE A HG21 1 
ATOM   1596 H HG22 . ILE A 1 105 ? 37.28616 -11.19089 8.59474  1.000 31.92084  ? 102 ILE A HG22 1 
ATOM   1597 H HG23 . ILE A 1 105 ? 35.82702 -10.61402 8.34646  1.000 31.92084  ? 102 ILE A HG23 1 
ATOM   1598 H HD11 . ILE A 1 105 ? 35.37298 -12.38707 5.68424  1.000 43.13917  ? 102 ILE A HD11 1 
ATOM   1599 H HD12 . ILE A 1 105 ? 35.38578 -11.81541 4.20217  1.000 43.13917  ? 102 ILE A HD12 1 
ATOM   1600 H HD13 . ILE A 1 105 ? 36.74522 -12.25847 4.89436  1.000 43.13917  ? 102 ILE A HD13 1 
ATOM   1601 N N    . ALA A 1 106 ? 37.73875 -8.30594  9.41488  1.000 22.00375  ? 103 ALA A N    1 
ATOM   1602 C CA   . ALA A 1 106 ? 38.53936 -8.05736  10.60879 1.000 19.87271  ? 103 ALA A CA   1 
ATOM   1603 C C    . ALA A 1 106 ? 37.91207 -8.75749  11.80306 1.000 20.89128  ? 103 ALA A C    1 
ATOM   1604 O O    . ALA A 1 106 ? 36.71987 -8.59398  12.07053 1.000 20.78880  ? 103 ALA A O    1 
ATOM   1605 C CB   . ALA A 1 106 ? 38.66559 -6.55447  10.89120 1.000 19.96937  ? 103 ALA A CB   1 
ATOM   1606 H H    . ALA A 1 106 ? 36.90571 -8.11566  9.51204  1.000 26.42349  ? 103 ALA A H    1 
ATOM   1607 H HA   . ALA A 1 106 ? 39.42700 -8.42483  10.47481 1.000 23.86624  ? 103 ALA A HA   1 
ATOM   1608 H HB1  . ALA A 1 106 ? 39.28184 -6.42236  11.62854 1.000 23.98222  ? 103 ALA A HB1  1 
ATOM   1609 H HB2  . ALA A 1 106 ? 39.00083 -6.11085  10.09639 1.000 23.98222  ? 103 ALA A HB2  1 
ATOM   1610 H HB3  . ALA A 1 106 ? 37.79204 -6.20224  11.12303 1.000 23.98222  ? 103 ALA A HB3  1 
ATOM   1611 N N    . ALA A 1 107 ? 38.71517 -9.52502  12.52377 1.000 19.29917  ? 104 ALA A N    1 
ATOM   1612 C CA   . ALA A 1 107 ? 38.23302 -10.30641 13.65298 1.000 17.68895  ? 104 ALA A CA   1 
ATOM   1613 C C    . ALA A 1 107 ? 39.27513 -10.28828 14.76367 1.000 19.71131  ? 104 ALA A C    1 
ATOM   1614 O O    . ALA A 1 107 ? 40.47876 -10.37853 14.50233 1.000 19.63853  ? 104 ALA A O    1 
ATOM   1615 C CB   . ALA A 1 107 ? 37.93893 -11.74647 13.24330 1.000 18.22198  ? 104 ALA A CB   1 
ATOM   1616 H H    . ALA A 1 107 ? 39.55801 -9.61191  12.37656 1.000 23.17798  ? 104 ALA A H    1 
ATOM   1617 H HA   . ALA A 1 107 ? 37.41659 -9.91113  13.99661 1.000 21.24572  ? 104 ALA A HA   1 
ATOM   1618 H HB1  . ALA A 1 107 ? 37.63344 -12.23982 14.02060 1.000 21.88535  ? 104 ALA A HB1  1 
ATOM   1619 H HB2  . ALA A 1 107 ? 37.25034 -11.74610 12.56012 1.000 21.88535  ? 104 ALA A HB2  1 
ATOM   1620 H HB3  . ALA A 1 107 ? 38.75042 -12.14766 12.89482 1.000 21.88535  ? 104 ALA A HB3  1 
ATOM   1621 N N    . ILE A 1 108 ? 38.81278 -10.20377 16.00634 1.000 18.55047  ? 105 ILE A N    1 
ATOM   1622 C CA   . ILE A 1 108 ? 39.73100 -10.06642 17.13374 1.000 19.47205  ? 105 ILE A CA   1 
ATOM   1623 C C    . ILE A 1 108 ? 39.42911 -11.08329 18.22189 1.000 20.17298  ? 105 ILE A C    1 
ATOM   1624 O O    . ILE A 1 108 ? 38.26172 -11.44323 18.43895 1.000 18.75952  ? 105 ILE A O    1 
ATOM   1625 C CB   . ILE A 1 108 ? 39.69158 -8.62541  17.68999 1.000 20.18542  ? 105 ILE A CB   1 
ATOM   1626 C CG1  . ILE A 1 108 ? 40.64557 -8.47558  18.87993 1.000 19.66651  ? 105 ILE A CG1  1 
ATOM   1627 C CG2  . ILE A 1 108 ? 38.25743 -8.24016  18.08762 1.000 19.47496  ? 105 ILE A CG2  1 
ATOM   1628 C CD1  . ILE A 1 108 ? 40.92930 -7.05440  19.25273 1.000 19.51285  ? 105 ILE A CD1  1 
ATOM   1629 H H    . ILE A 1 108 ? 37.98044 -10.22324 16.22184 1.000 22.27955  ? 105 ILE A H    1 
ATOM   1630 H HA   . ILE A 1 108 ? 40.63052 -10.24890 16.81993 1.000 23.38544  ? 105 ILE A HA   1 
ATOM   1631 H HB   . ILE A 1 108 ? 39.98777 -8.02312  16.98970 1.000 24.24148  ? 105 ILE A HB   1 
ATOM   1632 H HG12 . ILE A 1 108 ? 40.25130 -8.91071  19.65202 1.000 23.61879  ? 105 ILE A HG12 1 
ATOM   1633 H HG13 . ILE A 1 108 ? 41.49030 -8.89704  18.65697 1.000 23.61879  ? 105 ILE A HG13 1 
ATOM   1634 H HG21 . ILE A 1 108 ? 38.24430 -7.30900  18.35902 1.000 23.38894  ? 105 ILE A HG21 1 
ATOM   1635 H HG22 . ILE A 1 108 ? 37.67240 -8.37072  17.32500 1.000 23.38894  ? 105 ILE A HG22 1 
ATOM   1636 H HG23 . ILE A 1 108 ? 37.97177 -8.80336  18.82391 1.000 23.38894  ? 105 ILE A HG23 1 
ATOM   1637 H HD11 . ILE A 1 108 ? 41.63020 -7.03766  19.92308 1.000 23.43440  ? 105 ILE A HD11 1 
ATOM   1638 H HD12 . ILE A 1 108 ? 41.21641 -6.57174  18.46184 1.000 23.43440  ? 105 ILE A HD12 1 
ATOM   1639 H HD13 . ILE A 1 108 ? 40.12093 -6.65403  19.60931 1.000 23.43440  ? 105 ILE A HD13 1 
HETATM 1640 N N    . CSO A 1 109 ? 40.49422 -11.57371 18.86568 1.000 18.04120  ? 106 CSO A N    1 
HETATM 1641 C CA   . CSO A 1 109 ? 40.35850 -12.38362 20.08276 1.000 19.82878  ? 106 CSO A CA   1 
HETATM 1642 C CB   . CSO A 1 109 ? 39.42423 -11.65985 21.08205 1.000 21.37781  ? 106 CSO A CB   1 
HETATM 1643 S SG   . CSO A 1 109 ? 39.46711 -12.42220 22.73083 1.000 28.85047  ? 106 CSO A SG   1 
HETATM 1644 C C    . CSO A 1 109 ? 39.83226 -13.78295 19.72197 1.000 21.30471  ? 106 CSO A C    1 
HETATM 1645 O O    . CSO A 1 109 ? 40.50818 -14.56700 19.05079 1.000 17.38277  ? 106 CSO A O    1 
HETATM 1646 O OD   . CSO A 1 109 ? 37.84033 -12.57074 23.41397 1.000 39.03088  ? 106 CSO A OD   1 
HETATM 1647 H HA   . CSO A 1 109 ? 41.22345 -12.50004 20.52852 1.000 23.81352  ? 106 CSO A HA   1 
HETATM 1648 H HB2  . CSO A 1 109 ? 38.51230 -11.70063 20.75399 1.000 25.67236  ? 106 CSO A HB2  1 
HETATM 1649 H HB3  . CSO A 1 109 ? 39.70437 -10.73529 21.16933 1.000 25.67236  ? 106 CSO A HB3  1 
HETATM 1650 H HD   . CSO A 1 109 ? 37.45957 -11.69039 23.55859 1.000 46.85604  ? 106 CSO A HD   1 
ATOM   1651 N N    . ALA A 1 110 ? 38.61952 -14.10353 20.15736 1.000 18.95666  ? 107 ALA A N    1 
ATOM   1652 C CA   . ALA A 1 110 ? 37.99048 -15.38232 19.77933 1.000 22.33593  ? 107 ALA A CA   1 
ATOM   1653 C C    . ALA A 1 110 ? 37.25462 -15.25226 18.44719 1.000 21.11407  ? 107 ALA A C    1 
ATOM   1654 O O    . ALA A 1 110 ? 36.87192 -16.24911 17.83354 1.000 19.10801  ? 107 ALA A O    1 
ATOM   1655 C CB   . ALA A 1 110 ? 37.03615 -15.85453 20.86324 1.000 25.33693  ? 107 ALA A CB   1 
ATOM   1656 H H    . ALA A 1 110 ? 38.13762 -13.60764 20.66869 1.000 22.76698  ? 107 ALA A H    1 
ATOM   1657 H HA   . ALA A 1 110 ? 38.68423 -16.05321 19.68176 1.000 26.82209  ? 107 ALA A HA   1 
ATOM   1658 H HB1  . ALA A 1 110 ? 36.62918 -16.68952 20.58383 1.000 30.42329  ? 107 ALA A HB1  1 
ATOM   1659 H HB2  . ALA A 1 110 ? 37.53317 -15.98766 21.68552 1.000 30.42329  ? 107 ALA A HB2  1 
ATOM   1660 H HB3  . ALA A 1 110 ? 36.35104 -15.18084 20.99621 1.000 30.42329  ? 107 ALA A HB3  1 
ATOM   1661 N N    . GLY A 1 111 ? 37.06582 -14.00460 17.99824 1.000 19.89252  ? 108 GLY A N    1 
ATOM   1662 C CA   . GLY A 1 111 ? 36.32339 -13.75032 16.78312 1.000 20.84635  ? 108 GLY A CA   1 
ATOM   1663 C C    . GLY A 1 111 ? 36.78670 -14.51288 15.56116 1.000 20.00934  ? 108 GLY A C    1 
ATOM   1664 O O    . GLY A 1 111 ? 35.94981 -14.91847 14.74051 1.000 20.85219  ? 108 GLY A O    1 
ATOM   1665 H H    . GLY A 1 111 ? 37.36148 -13.29640 18.38637 1.000 23.89001  ? 108 GLY A H    1 
ATOM   1666 H HA2  . GLY A 1 111 ? 35.39384 -13.98103 16.93673 1.000 25.03460  ? 108 GLY A HA2  1 
ATOM   1667 H HA3  . GLY A 1 111 ? 36.38421 -12.80424 16.57787 1.000 25.03460  ? 108 GLY A HA3  1 
ATOM   1668 N N    . PRO A 1 112 ? 38.09519 -14.70520 15.37613 1.000 19.83331  ? 109 PRO A N    1 
ATOM   1669 C CA   . PRO A 1 112 ? 38.55567 -15.39068 14.15637 1.000 20.47270  ? 109 PRO A CA   1 
ATOM   1670 C C    . PRO A 1 112 ? 38.06870 -16.82223 14.03963 1.000 20.75112  ? 109 PRO A C    1 
ATOM   1671 O O    . PRO A 1 112 ? 38.05034 -17.36277 12.92119 1.000 21.34886  ? 109 PRO A O    1 
ATOM   1672 C CB   . PRO A 1 112 ? 40.08655 -15.32635 14.26333 1.000 19.26321  ? 109 PRO A CB   1 
ATOM   1673 C CG   . PRO A 1 112 ? 40.35570 -14.10663 15.12904 1.000 18.81941  ? 109 PRO A CG   1 
ATOM   1674 C CD   . PRO A 1 112 ? 39.21068 -14.09874 16.13380 1.000 19.91470  ? 109 PRO A CD   1 
ATOM   1675 H HA   . PRO A 1 112 ? 38.27131 -14.89231 13.37427 1.000 24.58623  ? 109 PRO A HA   1 
ATOM   1676 H HB2  . PRO A 1 112 ? 40.42458 -16.13325 14.68231 1.000 23.13483  ? 109 PRO A HB2  1 
ATOM   1677 H HB3  . PRO A 1 112 ? 40.47716 -15.22170 13.38165 1.000 23.13483  ? 109 PRO A HB3  1 
ATOM   1678 H HG2  . PRO A 1 112 ? 41.21187 -14.19717 15.57589 1.000 22.60228  ? 109 PRO A HG2  1 
ATOM   1679 H HG3  . PRO A 1 112 ? 40.34864 -13.30349 14.58515 1.000 22.60228  ? 109 PRO A HG3  1 
ATOM   1680 H HD2  . PRO A 1 112 ? 39.43049 -14.63310 16.91293 1.000 23.91662  ? 109 PRO A HD2  1 
ATOM   1681 H HD3  . PRO A 1 112 ? 38.99339 -13.19268 16.40350 1.000 23.91662  ? 109 PRO A HD3  1 
ATOM   1682 N N    . THR A 1 113 ? 37.68590 -17.46522 15.14842 1.000 20.38127  ? 110 THR A N    1 
ATOM   1683 C CA   . THR A 1 113 ? 37.21353 -18.84077 15.03743 1.000 22.07992  ? 110 THR A CA   1 
ATOM   1684 C C    . THR A 1 113 ? 35.93404 -18.92450 14.21240 1.000 22.77859  ? 110 THR A C    1 
ATOM   1685 O O    . THR A 1 113 ? 35.60312 -20.00010 13.70574 1.000 24.58020  ? 110 THR A O    1 
ATOM   1686 C CB   . THR A 1 113 ? 36.99404 -19.46646 16.41727 1.000 23.97116  ? 110 THR A CB   1 
ATOM   1687 O OG1  . THR A 1 113 ? 35.93591 -18.80016 17.12274 1.000 23.09224  ? 110 THR A OG1  1 
ATOM   1688 C CG2  . THR A 1 113 ? 38.26776 -19.41348 17.23533 1.000 24.57424  ? 110 THR A CG2  1 
ATOM   1689 H H    . THR A 1 113 ? 37.69122 -17.13735 15.94345 1.000 24.47651  ? 110 THR A H    1 
ATOM   1690 H HA   . THR A 1 113 ? 37.90098 -19.36729 14.60031 1.000 26.51489  ? 110 THR A HA   1 
ATOM   1691 H HB   . THR A 1 113 ? 36.74162 -20.39557 16.29921 1.000 28.78437  ? 110 THR A HB   1 
ATOM   1692 H HG1  . THR A 1 113 ? 36.13216 -17.99159 17.23809 1.000 27.72967  ? 110 THR A HG1  1 
ATOM   1693 H HG21 . THR A 1 113 ? 38.49791 -18.49184 17.43158 1.000 29.50806  ? 110 THR A HG21 1 
ATOM   1694 H HG22 . THR A 1 113 ? 38.14602 -19.89215 18.07016 1.000 29.50806  ? 110 THR A HG22 1 
ATOM   1695 H HG23 . THR A 1 113 ? 38.99626 -19.82162 16.74177 1.000 29.50806  ? 110 THR A HG23 1 
ATOM   1696 N N    . ALA A 1 114 ? 35.21556 -17.80738 14.05048 1.000 20.76268  ? 111 ALA A N    1 
ATOM   1697 C CA   . ALA A 1 114 ? 34.05607 -17.79336 13.16018 1.000 23.29984  ? 111 ALA A CA   1 
ATOM   1698 C C    . ALA A 1 114 ? 34.46842 -17.93652 11.69992 1.000 23.82341  ? 111 ALA A C    1 
ATOM   1699 O O    . ALA A 1 114 ? 33.70543 -18.47852 10.88827 1.000 26.01047  ? 111 ALA A O    1 
ATOM   1700 C CB   . ALA A 1 114 ? 33.25386 -16.50449 13.34323 1.000 24.30289  ? 111 ALA A CB   1 
ATOM   1701 H H    . ALA A 1 114 ? 35.37729 -17.05741 14.43904 1.000 24.93419  ? 111 ALA A H    1 
ATOM   1702 H HA   . ALA A 1 114 ? 33.48445 -18.54076 13.39584 1.000 27.97880  ? 111 ALA A HA   1 
ATOM   1703 H HB1  . ALA A 1 114 ? 32.48830 -16.52176 12.74781 1.000 29.18245  ? 111 ALA A HB1  1 
ATOM   1704 H HB2  . ALA A 1 114 ? 32.95530 -16.44647 14.26431 1.000 29.18245  ? 111 ALA A HB2  1 
ATOM   1705 H HB3  . ALA A 1 114 ? 33.82097 -15.74671 13.13098 1.000 29.18245  ? 111 ALA A HB3  1 
ATOM   1706 N N    . LEU A 1 115 ? 35.65686 -17.44270 11.34754 1.000 20.16701  ? 112 LEU A N    1 
ATOM   1707 C CA   . LEU A 1 115 ? 36.16301 -17.63541 9.99666  1.000 23.20394  ? 112 LEU A CA   1 
ATOM   1708 C C    . LEU A 1 115 ? 36.35219 -19.11320 9.69634  1.000 24.30965  ? 112 LEU A C    1 
ATOM   1709 O O    . LEU A 1 115 ? 36.05272 -19.57864 8.58735  1.000 24.95719  ? 112 LEU A O    1 
ATOM   1710 C CB   . LEU A 1 115 ? 37.48431 -16.88986 9.82254  1.000 23.07014  ? 112 LEU A CB   1 
ATOM   1711 C CG   . LEU A 1 115 ? 37.47374 -15.39895 10.18038 1.000 25.74767  ? 112 LEU A CG   1 
ATOM   1712 C CD1  . LEU A 1 115 ? 38.86604 -14.81417 9.97359  1.000 29.72243  ? 112 LEU A CD1  1 
ATOM   1713 C CD2  . LEU A 1 115 ? 36.45084 -14.66014 9.37314  1.000 27.72281  ? 112 LEU A CD2  1 
ATOM   1714 H H    . LEU A 1 115 ? 36.17981 -16.99915 11.86656 1.000 24.21940  ? 112 LEU A H    1 
ATOM   1715 H HA   . LEU A 1 115 ? 35.52319 -17.27097 9.36521  1.000 27.86371  ? 112 LEU A HA   1 
ATOM   1716 H HB2  . LEU A 1 115 ? 38.14734 -17.31528 10.38850 1.000 27.70314  ? 112 LEU A HB2  1 
ATOM   1717 H HB3  . LEU A 1 115 ? 37.74903 -16.95890 8.89192  1.000 27.70314  ? 112 LEU A HB3  1 
ATOM   1718 H HG   . LEU A 1 115 ? 37.23035 -15.29096 11.11312 1.000 30.91618  ? 112 LEU A HG   1 
ATOM   1719 H HD11 . LEU A 1 115 ? 38.85308 -13.87479 10.21501 1.000 35.68590  ? 112 LEU A HD11 1 
ATOM   1720 H HD12 . LEU A 1 115 ? 39.49582 -15.29159 10.53606 1.000 35.68590  ? 112 LEU A HD12 1 
ATOM   1721 H HD13 . LEU A 1 115 ? 39.11465 -14.91267 9.04118  1.000 35.68590  ? 112 LEU A HD13 1 
ATOM   1722 H HD21 . LEU A 1 115 ? 36.53907 -13.70962 9.54527  1.000 33.28635  ? 112 LEU A HD21 1 
ATOM   1723 H HD22 . LEU A 1 115 ? 36.60039 -14.84114 8.43198  1.000 33.28635  ? 112 LEU A HD22 1 
ATOM   1724 H HD23 . LEU A 1 115 ? 35.56611 -14.96238 9.63160  1.000 33.28635  ? 112 LEU A HD23 1 
ATOM   1725 N N    . LEU A 1 116 ? 36.86493 -19.86546 10.67066 1.000 23.74477  ? 113 LEU A N    1 
ATOM   1726 C CA   . LEU A 1 116 ? 37.01133 -21.30316 10.48790 1.000 24.40762  ? 113 LEU A CA   1 
ATOM   1727 C C    . LEU A 1 116 ? 35.65123 -21.95393 10.31041 1.000 25.61574  ? 113 LEU A C    1 
ATOM   1728 O O    . LEU A 1 116 ? 35.45682 -22.76578 9.40441  1.000 24.19181  ? 113 LEU A O    1 
ATOM   1729 C CB   . LEU A 1 116 ? 37.74511 -21.91610 11.67797 1.000 24.75883  ? 113 LEU A CB   1 
ATOM   1730 C CG   . LEU A 1 116 ? 37.84827 -23.44146 11.71098 1.000 26.50526  ? 113 LEU A CG   1 
ATOM   1731 C CD1  . LEU A 1 116 ? 38.61532 -23.94414 10.48665 1.000 27.51702  ? 113 LEU A CD1  1 
ATOM   1732 C CD2  . LEU A 1 116 ? 38.51155 -23.88864 12.99873 1.000 27.74976  ? 113 LEU A CD2  1 
ATOM   1733 H H    . LEU A 1 116 ? 37.13063 -19.57068 11.43362 1.000 28.51271  ? 113 LEU A H    1 
ATOM   1734 H HA   . LEU A 1 116 ? 37.54367 -21.46875 9.69411  1.000 29.30813  ? 113 LEU A HA   1 
ATOM   1735 H HB2  . LEU A 1 116 ? 38.65125 -21.56998 11.68175 1.000 29.72958  ? 113 LEU A HB2  1 
ATOM   1736 H HB3  . LEU A 1 116 ? 37.28308 -21.64509 12.48666 1.000 29.72958  ? 113 LEU A HB3  1 
ATOM   1737 H HG   . LEU A 1 116 ? 36.96112 -23.83272 11.68318 1.000 31.82530  ? 113 LEU A HG   1 
ATOM   1738 H HD11 . LEU A 1 116 ? 38.69747 -24.90919 10.53977 1.000 33.03941  ? 113 LEU A HD11 1 
ATOM   1739 H HD12 . LEU A 1 116 ? 38.12775 -23.69728 9.68525  1.000 33.03941  ? 113 LEU A HD12 1 
ATOM   1740 H HD13 . LEU A 1 116 ? 39.49581 -23.53727 10.47666 1.000 33.03941  ? 113 LEU A HD13 1 
ATOM   1741 H HD21 . LEU A 1 116 ? 38.56701 -24.85703 13.00566 1.000 33.31870  ? 113 LEU A HD21 1 
ATOM   1742 H HD22 . LEU A 1 116 ? 39.40170 -23.50601 13.04489 1.000 33.31870  ? 113 LEU A HD22 1 
ATOM   1743 H HD23 . LEU A 1 116 ? 37.98046 -23.58235 13.75042 1.000 33.31870  ? 113 LEU A HD23 1 
ATOM   1744 N N    . ALA A 1 117 ? 34.69304 -21.60496 11.17303 1.000 23.64559  ? 114 ALA A N    1 
ATOM   1745 C CA   . ALA A 1 117 ? 33.37186 -22.21658 11.09889 1.000 26.13392  ? 114 ALA A CA   1 
ATOM   1746 C C    . ALA A 1 117 ? 32.74817 -22.02821 9.72150  1.000 27.55592  ? 114 ALA A C    1 
ATOM   1747 O O    . ALA A 1 117 ? 32.06685 -22.92409 9.21106  1.000 28.69143  ? 114 ALA A O    1 
ATOM   1748 C CB   . ALA A 1 117 ? 32.46617 -21.62236 12.17424 1.000 28.02808  ? 114 ALA A CB   1 
ATOM   1749 H H    . ALA A 1 117 ? 34.78360 -21.02437 11.80098 1.000 28.39368  ? 114 ALA A H    1 
ATOM   1750 H HA   . ALA A 1 117 ? 33.45972 -23.16883 11.26133 1.000 31.37969  ? 114 ALA A HA   1 
ATOM   1751 H HB1  . ALA A 1 117 ? 31.58618 -22.02422 12.10339 1.000 33.65267  ? 114 ALA A HB1  1 
ATOM   1752 H HB2  . ALA A 1 117 ? 32.84639 -21.81032 13.04659 1.000 33.65267  ? 114 ALA A HB2  1 
ATOM   1753 H HB3  . ALA A 1 117 ? 32.40377 -20.66369 12.04019 1.000 33.65267  ? 114 ALA A HB3  1 
ATOM   1754 N N    . HIS A 1 118 ? 32.96363 -20.86918 9.10717  1.000 26.30273  ? 115 HIS A N    1 
ATOM   1755 C CA   . HIS A 1 118 ? 32.34896 -20.53063 7.83109  1.000 28.59631  ? 115 HIS A CA   1 
ATOM   1756 C C    . HIS A 1 118 ? 33.28796 -20.72016 6.64442  1.000 28.67222  ? 115 HIS A C    1 
ATOM   1757 O O    . HIS A 1 118 ? 32.94875 -20.30451 5.52944  1.000 28.46247  ? 115 HIS A O    1 
ATOM   1758 C CB   . HIS A 1 118 ? 31.83748 -19.08882 7.87834  1.000 28.42929  ? 115 HIS A CB   1 
ATOM   1759 C CG   . HIS A 1 118 ? 30.80700 -18.85591 8.93940  1.000 29.98483  ? 115 HIS A CG   1 
ATOM   1760 N ND1  . HIS A 1 118 ? 29.71797 -19.68386 9.11599  1.000 28.42079  ? 115 HIS A ND1  1 
ATOM   1761 C CD2  . HIS A 1 118 ? 30.70051 -17.88883 9.88028  1.000 27.64769  ? 115 HIS A CD2  1 
ATOM   1762 C CE1  . HIS A 1 118 ? 28.99650 -19.24701 10.13204 1.000 29.70254  ? 115 HIS A CE1  1 
ATOM   1763 N NE2  . HIS A 1 118 ? 29.56474 -18.15264 10.60551 1.000 26.93810  ? 115 HIS A NE2  1 
ATOM   1764 H H    . HIS A 1 118 ? 33.47339 -20.25011 9.41780  1.000 31.58226  ? 115 HIS A H    1 
ATOM   1765 H HA   . HIS A 1 118 ? 31.59090 -21.11835 7.68673  1.000 34.33455  ? 115 HIS A HA   1 
ATOM   1766 H HB2  . HIS A 1 118 ? 32.58540 -18.49706 8.05535  1.000 34.13413  ? 115 HIS A HB2  1 
ATOM   1767 H HB3  . HIS A 1 118 ? 31.43715 -18.87055 7.02218  1.000 34.13413  ? 115 HIS A HB3  1 
ATOM   1768 H HD2  . HIS A 1 118 ? 31.28668 -17.17877 10.01109 1.000 33.19621  ? 115 HIS A HD2  1 
ATOM   1769 H HE1  . HIS A 1 118 ? 28.22066 -19.64242 10.45856 1.000 35.66204  ? 115 HIS A HE1  1 
ATOM   1770 H HE2  . HIS A 1 118 ? 29.27079 -17.68136 11.26209 1.000 32.34470  ? 115 HIS A HE2  1 
ATOM   1771 N N    . GLU A 1 119 ? 34.46373 -21.31752 6.86419  1.000 27.30583  ? 116 GLU A N    1 
ATOM   1772 C CA   . GLU A 1 119 ? 35.40166 -21.65539 5.79012  1.000 29.68030  ? 116 GLU A CA   1 
ATOM   1773 C C    . GLU A 1 119 ? 35.83733 -20.41615 5.01460  1.000 28.37151  ? 116 GLU A C    1 
ATOM   1774 O O    . GLU A 1 119 ? 35.80112 -20.37847 3.78244  1.000 28.52243  ? 116 GLU A O    1 
ATOM   1775 C CB   . GLU A 1 119 ? 34.79105 -22.70238 4.85276  1.000 33.65514  ? 116 GLU A CB   1 
ATOM   1776 C CG   . GLU A 1 119 ? 34.41194 -24.00160 5.56090  1.000 41.16564  ? 116 GLU A CG   1 
ATOM   1777 C CD   . GLU A 1 119 ? 34.07068 -25.12919 4.59166  1.000 66.13033  ? 116 GLU A CD   1 
ATOM   1778 O OE1  . GLU A 1 119 ? 33.81686 -24.84743 3.39823  1.000 61.37599  ? 116 GLU A OE1  1 
ATOM   1779 O OE2  . GLU A 1 119 ? 34.07245 -26.29784 5.02807  1.000 54.39908  ? 116 GLU A OE2  1 
ATOM   1780 H H    . GLU A 1 119 ? 34.74643 -21.54190 7.64478  1.000 32.78598  ? 116 GLU A H    1 
ATOM   1781 H HA   . GLU A 1 119 ? 36.20037 -22.03181 6.19170  1.000 35.63534  ? 116 GLU A HA   1 
ATOM   1782 H HB2  . GLU A 1 119 ? 33.98678 -22.33488 4.45401  1.000 40.40515  ? 116 GLU A HB2  1 
ATOM   1783 H HB3  . GLU A 1 119 ? 35.43591 -22.91753 4.16083  1.000 40.40515  ? 116 GLU A HB3  1 
ATOM   1784 H HG2  . GLU A 1 119 ? 35.15874 -24.29251 6.10732  1.000 49.41775  ? 116 GLU A HG2  1 
ATOM   1785 H HG3  . GLU A 1 119 ? 33.63498 -23.84147 6.11910  1.000 49.41775  ? 116 GLU A HG3  1 
ATOM   1786 N N    . ILE A 1 120 ? 36.28738 -19.40720 5.75267  1.000 26.20122  ? 117 ILE A N    1 
ATOM   1787 C CA   . ILE A 1 120 ? 36.66469 -18.11826 5.18997  1.000 25.65310  ? 117 ILE A CA   1 
ATOM   1788 C C    . ILE A 1 120 ? 38.17707 -17.98162 5.26553  1.000 27.54283  ? 117 ILE A C    1 
ATOM   1789 O O    . ILE A 1 120 ? 38.77247 -18.16668 6.33325  1.000 25.85888  ? 117 ILE A O    1 
ATOM   1790 C CB   . ILE A 1 120 ? 35.98444 -16.95478 5.93377  1.000 25.28849  ? 117 ILE A CB   1 
ATOM   1791 C CG1  . ILE A 1 120 ? 34.46980 -17.10064 5.90713  1.000 28.46797  ? 117 ILE A CG1  1 
ATOM   1792 C CG2  . ILE A 1 120 ? 36.42447 -15.62263 5.34507  1.000 28.34609  ? 117 ILE A CG2  1 
ATOM   1793 C CD1  . ILE A 1 120 ? 33.87169 -16.98854 4.51861  1.000 30.82282  ? 117 ILE A CD1  1 
ATOM   1794 H H    . ILE A 1 120 ? 36.38506 -19.44818 6.60612  1.000 31.46044  ? 117 ILE A H    1 
ATOM   1795 H HA   . ILE A 1 120 ? 36.39598 -18.09235 4.25829  1.000 30.80270  ? 117 ILE A HA   1 
ATOM   1796 H HB   . ILE A 1 120 ? 36.26187 -16.98286 6.86282  1.000 30.36518  ? 117 ILE A HB   1 
ATOM   1797 H HG12 . ILE A 1 120 ? 34.23379 -17.97198 6.26205  1.000 34.18054  ? 117 ILE A HG12 1 
ATOM   1798 H HG13 . ILE A 1 120 ? 34.07922 -16.40222 6.45536  1.000 34.18054  ? 117 ILE A HG13 1 
ATOM   1799 H HG21 . ILE A 1 120 ? 35.83012 -14.92510 5.66307  1.000 34.03429  ? 117 ILE A HG21 1 
ATOM   1800 H HG22 . ILE A 1 120 ? 37.33350 -15.43711 5.62817  1.000 34.03429  ? 117 ILE A HG22 1 
ATOM   1801 H HG23 . ILE A 1 120 ? 36.38378 -15.67613 4.37741  1.000 34.03429  ? 117 ILE A HG23 1 
ATOM   1802 H HD11 . ILE A 1 120 ? 32.90808 -17.08016 4.58149  1.000 37.00637  ? 117 ILE A HD11 1 
ATOM   1803 H HD12 . ILE A 1 120 ? 34.09797 -16.12189 4.14630  1.000 37.00637  ? 117 ILE A HD12 1 
ATOM   1804 H HD13 . ILE A 1 120 ? 34.23525 -17.69353 3.96029  1.000 37.00637  ? 117 ILE A HD13 1 
ATOM   1805 N N    . GLY A 1 121 ? 38.79301 -17.63971 4.13957  1.000 26.68287  ? 118 GLY A N    1 
ATOM   1806 C CA   . GLY A 1 121 ? 40.20213 -17.27998 4.12630  1.000 27.12782  ? 118 GLY A CA   1 
ATOM   1807 C C    . GLY A 1 121 ? 41.18393 -18.38719 4.44339  1.000 26.43989  ? 118 GLY A C    1 
ATOM   1808 O O    . GLY A 1 121 ? 42.28519 -18.11044 4.95074  1.000 23.90398  ? 118 GLY A O    1 
ATOM   1809 H H    . GLY A 1 121 ? 38.41520 -17.60831 3.36765  1.000 32.03843  ? 118 GLY A H    1 
ATOM   1810 H HA2  . GLY A 1 121 ? 40.42204 -16.94328 3.24359  1.000 32.57237  ? 118 GLY A HA2  1 
ATOM   1811 H HA3  . GLY A 1 121 ? 40.34238 -16.57468 4.77730  1.000 32.57237  ? 118 GLY A HA3  1 
ATOM   1812 N N    . PHE A 1 122 ? 40.82238 -19.63661 4.16440  1.000 24.77163  ? 119 PHE A N    1 
ATOM   1813 C CA   . PHE A 1 122 ? 41.75540 -20.73403 4.38131  1.000 24.99997  ? 119 PHE A CA   1 
ATOM   1814 C C    . PHE A 1 122 ? 43.07667 -20.44771 3.67441  1.000 26.60156  ? 119 PHE A C    1 
ATOM   1815 O O    . PHE A 1 122 ? 43.10682 -19.93317 2.55345  1.000 24.18993  ? 119 PHE A O    1 
ATOM   1816 C CB   . PHE A 1 122 ? 41.17282 -22.05779 3.87583  1.000 26.84627  ? 119 PHE A CB   1 
ATOM   1817 C CG   . PHE A 1 122 ? 40.17292 -22.68442 4.79735  1.000 26.45403  ? 119 PHE A CG   1 
ATOM   1818 C CD1  . PHE A 1 122 ? 39.73751 -22.03380 5.93738  1.000 23.68549  ? 119 PHE A CD1  1 
ATOM   1819 C CD2  . PHE A 1 122 ? 39.67029 -23.94381 4.52337  1.000 27.04438  ? 119 PHE A CD2  1 
ATOM   1820 C CE1  . PHE A 1 122 ? 38.80797 -22.64049 6.78902  1.000 26.19339  ? 119 PHE A CE1  1 
ATOM   1821 C CE2  . PHE A 1 122 ? 38.74263 -24.54387 5.36270  1.000 29.24087  ? 119 PHE A CE2  1 
ATOM   1822 C CZ   . PHE A 1 122 ? 38.31722 -23.89191 6.49545  1.000 27.22518  ? 119 PHE A CZ   1 
ATOM   1823 H H    . PHE A 1 122 ? 40.05527 -19.87044 3.85381  1.000 29.74494  ? 119 PHE A H    1 
ATOM   1824 H HA   . PHE A 1 122 ? 41.91675 -20.82677 5.33329  1.000 30.01894  ? 119 PHE A HA   1 
ATOM   1825 H HB2  . PHE A 1 122 ? 40.73014 -21.89737 3.02777  1.000 32.23450  ? 119 PHE A HB2  1 
ATOM   1826 H HB3  . PHE A 1 122 ? 41.89875 -22.69005 3.75677  1.000 32.23450  ? 119 PHE A HB3  1 
ATOM   1827 H HD1  . PHE A 1 122 ? 40.06488 -21.18707 6.13933  1.000 28.44157  ? 119 PHE A HD1  1 
ATOM   1828 H HD2  . PHE A 1 122 ? 39.95909 -24.39592 3.76371  1.000 32.47224  ? 119 PHE A HD2  1 
ATOM   1829 H HE1  . PHE A 1 122 ? 38.52136 -22.19723 7.55471  1.000 31.45105  ? 119 PHE A HE1  1 
ATOM   1830 H HE2  . PHE A 1 122 ? 38.40857 -25.38750 5.15877  1.000 35.10802  ? 119 PHE A HE2  1 
ATOM   1831 H HZ   . PHE A 1 122 ? 37.69958 -24.29538 7.06170  1.000 32.68919  ? 119 PHE A HZ   1 
ATOM   1832 N N    . GLY A 1 123 ? 44.17283 -20.80569 4.33373  1.000 23.49712  ? 120 GLY A N    1 
ATOM   1833 C CA   . GLY A 1 123 ? 45.50122 -20.54081 3.83956  1.000 23.85792  ? 120 GLY A CA   1 
ATOM   1834 C C    . GLY A 1 123 ? 46.10347 -19.24379 4.31839  1.000 25.26648  ? 120 GLY A C    1 
ATOM   1835 O O    . GLY A 1 123 ? 47.28123 -18.99265 4.04472  1.000 28.93525  ? 120 GLY A O    1 
ATOM   1836 H H    . GLY A 1 123 ? 44.16463 -21.21445 5.09033  1.000 28.21552  ? 120 GLY A H    1 
ATOM   1837 H HA2  . GLY A 1 123 ? 46.08711 -21.26131 4.11975  1.000 28.64849  ? 120 GLY A HA2  1 
ATOM   1838 H HA3  . GLY A 1 123 ? 45.47351 -20.51511 2.87029  1.000 28.64849  ? 120 GLY A HA3  1 
ATOM   1839 N N    . SER A 1 124 ? 45.33956 -18.41675 5.02636  1.000 25.48703  ? 121 SER A N    1 
ATOM   1840 C CA   . SER A 1 124 ? 45.84088 -17.14145 5.51161  1.000 26.02942  ? 121 SER A CA   1 
ATOM   1841 C C    . SER A 1 124 ? 46.62299 -17.32340 6.80677  1.000 25.35860  ? 121 SER A C    1 
ATOM   1842 O O    . SER A 1 124 ? 46.43811 -18.29007 7.55017  1.000 24.27393  ? 121 SER A O    1 
ATOM   1843 C CB   . SER A 1 124 ? 44.69000 -16.15480 5.75367  1.000 27.20897  ? 121 SER A CB   1 
ATOM   1844 O OG   . SER A 1 124 ? 43.98142 -15.85901 4.56352  1.000 28.52617  ? 121 SER A OG   1 
ATOM   1845 H H    . SER A 1 124 ? 44.52143 -18.57450 5.23939  1.000 30.60342  ? 121 SER A H    1 
ATOM   1846 H HA   . SER A 1 124 ? 46.43212 -16.76681 4.84006  1.000 31.25428  ? 121 SER A HA   1 
ATOM   1847 H HB2  . SER A 1 124 ? 44.07418 -16.54664 6.39252  1.000 32.66975  ? 121 SER A HB2  1 
ATOM   1848 H HB3  . SER A 1 124 ? 45.05722 -15.33053 6.10950  1.000 32.66975  ? 121 SER A HB3  1 
ATOM   1849 H HG   . SER A 1 124 ? 43.66101 -16.56363 4.23726  1.000 34.25039  ? 121 SER A HG   1 
ATOM   1850 N N    . LYS A 1 125 ? 47.51856 -16.37599 7.06070  1.000 23.16062  ? 122 LYS A N    1 
ATOM   1851 C CA   . LYS A 1 125 ? 48.14470 -16.24593 8.36715  1.000 24.11132  ? 122 LYS A CA   1 
ATOM   1852 C C    . LYS A 1 125 ? 47.21995 -15.44106 9.27596  1.000 25.22770  ? 122 LYS A C    1 
ATOM   1853 O O    . LYS A 1 125 ? 46.75402 -14.36037 8.89596  1.000 22.85836  ? 122 LYS A O    1 
ATOM   1854 C CB   . LYS A 1 125 ? 49.50093 -15.55905 8.24216  1.000 26.63889  ? 122 LYS A CB   1 
ATOM   1855 C CG   . LYS A 1 125 ? 50.26904 -15.49577 9.54993  1.000 32.94870  ? 122 LYS A CG   1 
ATOM   1856 C CD   . LYS A 1 125 ? 51.63973 -14.86645 9.37532  1.000 40.15542  ? 122 LYS A CD   1 
ATOM   1857 C CE   . LYS A 1 125 ? 52.57589 -15.77655 8.61006  1.000 46.15226  ? 122 LYS A CE   1 
ATOM   1858 N NZ   . LYS A 1 125 ? 53.95828 -15.20036 8.53301  1.000 67.27326  ? 122 LYS A NZ   1 
ATOM   1859 H H    . LYS A 1 125 ? 47.78201 -15.79168 6.48730  1.000 27.81173  ? 122 LYS A H    1 
ATOM   1860 H HA   . LYS A 1 125 ? 48.29344 -17.12111 8.75811  1.000 28.95256  ? 122 LYS A HA   1 
ATOM   1861 H HB2  . LYS A 1 125 ? 50.04190 -16.04854 7.60289  1.000 31.98565  ? 122 LYS A HB2  1 
ATOM   1862 H HB3  . LYS A 1 125 ? 49.36394 -14.64977 7.93340  1.000 31.98565  ? 122 LYS A HB3  1 
ATOM   1863 H HG2  . LYS A 1 125 ? 49.76999 -14.96198 10.18784 1.000 39.55743  ? 122 LYS A HG2  1 
ATOM   1864 H HG3  . LYS A 1 125 ? 50.39034 -16.39500 9.89283  1.000 39.55743  ? 122 LYS A HG3  1 
ATOM   1865 H HD2  . LYS A 1 125 ? 51.55129 -14.03600 8.88193  1.000 48.20548  ? 122 LYS A HD2  1 
ATOM   1866 H HD3  . LYS A 1 125 ? 52.02756 -14.69442 10.24761 1.000 48.20548  ? 122 LYS A HD3  1 
ATOM   1867 H HE2  . LYS A 1 125 ? 52.62745 -16.63511 9.05853  1.000 55.40169  ? 122 LYS A HE2  1 
ATOM   1868 H HE3  . LYS A 1 125 ? 52.24306 -15.89368 7.70652  1.000 55.40169  ? 122 LYS A HE3  1 
ATOM   1869 H HZ1  . LYS A 1 125 ? 54.30619 -15.13363 9.34946  1.000 80.74690  ? 122 LYS A HZ1  1 
ATOM   1870 H HZ2  . LYS A 1 125 ? 54.47986 -15.72556 8.03882  1.000 80.74690  ? 122 LYS A HZ2  1 
ATOM   1871 H HZ3  . LYS A 1 125 ? 53.93057 -14.39102 8.16381  1.000 80.74690  ? 122 LYS A HZ3  1 
ATOM   1872 N N    . VAL A 1 126 ? 46.95188 -15.96842 10.47386 1.000 23.67589  ? 123 VAL A N    1 
ATOM   1873 C CA   . VAL A 1 126 ? 46.00891 -15.36284 11.40418 1.000 23.38434  ? 123 VAL A CA   1 
ATOM   1874 C C    . VAL A 1 126 ? 46.56037 -15.44224 12.81950 1.000 22.19993  ? 123 VAL A C    1 
ATOM   1875 O O    . VAL A 1 126 ? 47.42501 -16.26415 13.12661 1.000 22.47560  ? 123 VAL A O    1 
ATOM   1876 C CB   . VAL A 1 126 ? 44.63051 -16.05841 11.35779 1.000 24.10006  ? 123 VAL A CB   1 
ATOM   1877 C CG1  . VAL A 1 126 ? 44.05300 -16.03765 9.96105  1.000 23.66278  ? 123 VAL A CG1  1 
ATOM   1878 C CG2  . VAL A 1 126 ? 44.74858 -17.49992 11.85059 1.000 22.93669  ? 123 VAL A CG2  1 
ATOM   1879 H H    . VAL A 1 126 ? 47.31296 -16.69010 10.77119 1.000 28.43005  ? 123 VAL A H    1 
ATOM   1880 H HA   . VAL A 1 126 ? 45.90749 -14.42645 11.17226 1.000 28.08019  ? 123 VAL A HA   1 
ATOM   1881 H HB   . VAL A 1 126 ? 44.02539 -15.57294 11.94007 1.000 28.93905  ? 123 VAL A HB   1 
ATOM   1882 H HG11 . VAL A 1 126 ? 43.14692 -16.38284 9.98879  1.000 28.41432  ? 123 VAL A HG11 1 
ATOM   1883 H HG12 . VAL A 1 126 ? 44.04914 -15.12429 9.63446  1.000 28.41432  ? 123 VAL A HG12 1 
ATOM   1884 H HG13 . VAL A 1 126 ? 44.60096 -16.59279 9.38447  1.000 28.41432  ? 123 VAL A HG13 1 
ATOM   1885 H HG21 . VAL A 1 126 ? 43.96609 -17.99660 11.56439 1.000 27.54301  ? 123 VAL A HG21 1 
ATOM   1886 H HG22 . VAL A 1 126 ? 45.54899 -17.89788 11.47393 1.000 27.54301  ? 123 VAL A HG22 1 
ATOM   1887 H HG23 . VAL A 1 126 ? 44.80387 -17.49907 12.81901 1.000 27.54301  ? 123 VAL A HG23 1 
ATOM   1888 N N    . THR A 1 127 ? 46.04031 -14.57103 13.68919 1.000 21.99484  ? 124 THR A N    1 
ATOM   1889 C CA   . THR A 1 127 ? 46.27244 -14.66613 15.12450 1.000 20.43002  ? 124 THR A CA   1 
ATOM   1890 C C    . THR A 1 127 ? 44.92909 -14.69137 15.84267 1.000 20.78938  ? 124 THR A C    1 
ATOM   1891 O O    . THR A 1 127 ? 43.88145 -14.37390 15.26742 1.000 20.28184  ? 124 THR A O    1 
ATOM   1892 C CB   . THR A 1 127 ? 47.13997 -13.51534 15.66196 1.000 21.02504  ? 124 THR A CB   1 
ATOM   1893 O OG1  . THR A 1 127 ? 47.54706 -13.82394 17.00215 1.000 21.28034  ? 124 THR A OG1  1 
ATOM   1894 C CG2  . THR A 1 127 ? 46.37217 -12.19535 15.65206 1.000 20.91519  ? 124 THR A CG2  1 
ATOM   1895 H H    . THR A 1 127 ? 45.54226 -13.90720 13.46362 1.000 26.41279  ? 124 THR A H    1 
ATOM   1896 H HA   . THR A 1 127 ? 46.74465 -15.49180 15.31472 1.000 24.53500  ? 124 THR A HA   1 
ATOM   1897 H HB   . THR A 1 127 ? 47.92017 -13.40567 15.09613 1.000 25.24902  ? 124 THR A HB   1 
ATOM   1898 H HG1  . THR A 1 127 ? 47.94892 -14.56141 17.01773 1.000 25.55539  ? 124 THR A HG1  1 
ATOM   1899 H HG21 . THR A 1 127 ? 46.99134 -11.45095 15.71035 1.000 25.11722  ? 124 THR A HG21 1 
ATOM   1900 H HG22 . THR A 1 127 ? 45.86019 -12.11550 14.83206 1.000 25.11722  ? 124 THR A HG22 1 
ATOM   1901 H HG23 . THR A 1 127 ? 45.76457 -12.15931 16.40732 1.000 25.11722  ? 124 THR A HG23 1 
ATOM   1902 N N    . THR A 1 128 ? 44.96949 -15.13976 17.09381 1.000 20.03963  ? 125 THR A N    1 
ATOM   1903 C CA   . THR A 1 128 ? 43.78958 -15.19735 17.94155 1.000 19.34114  ? 125 THR A CA   1 
ATOM   1904 C C    . THR A 1 128 ? 44.22240 -14.88895 19.36768 1.000 21.08115  ? 125 THR A C    1 
ATOM   1905 O O    . THR A 1 128 ? 45.40990 -14.73393 19.65025 1.000 18.56346  ? 125 THR A O    1 
ATOM   1906 C CB   . THR A 1 128 ? 43.11521 -16.57245 17.90714 1.000 20.53568  ? 125 THR A CB   1 
ATOM   1907 O OG1  . THR A 1 128 ? 43.95063 -17.53063 18.57731 1.000 18.11841  ? 125 THR A OG1  1 
ATOM   1908 C CG2  . THR A 1 128 ? 42.86882 -17.04889 16.47133 1.000 19.84907  ? 125 THR A CG2  1 
ATOM   1909 H H    . THR A 1 128 ? 45.68435 -15.42146 17.48009 1.000 24.06654  ? 125 THR A H    1 
ATOM   1910 H HA   . THR A 1 128 ? 43.16115 -14.53218 17.61980 1.000 23.22835  ? 125 THR A HA   1 
ATOM   1911 H HB   . THR A 1 128 ? 42.25469 -16.50662 18.34993 1.000 24.66180  ? 125 THR A HB   1 
ATOM   1912 H HG1  . THR A 1 128 ? 43.92709 -17.40172 19.40702 1.000 21.76107  ? 125 THR A HG1  1 
ATOM   1913 H HG21 . THR A 1 128 ? 42.31481 -17.84509 16.47646 1.000 23.83787  ? 125 THR A HG21 1 
ATOM   1914 H HG22 . THR A 1 128 ? 42.41853 -16.35531 15.96430 1.000 23.83787  ? 125 THR A HG22 1 
ATOM   1915 H HG23 . THR A 1 128 ? 43.71315 -17.25565 16.04090 1.000 23.83787  ? 125 THR A HG23 1 
ATOM   1916 N N    . HIS A 1 129 ? 43.26095 -14.82987 20.28180 1.000 18.46238  ? 126 HIS A N    1 
ATOM   1917 C CA   . HIS A 1 129 ? 43.62059 -14.91933 21.68748 1.000 20.02470  ? 126 HIS A CA   1 
ATOM   1918 C C    . HIS A 1 129 ? 44.35439 -16.23864 21.92166 1.000 19.42831  ? 126 HIS A C    1 
ATOM   1919 O O    . HIS A 1 129 ? 43.98750 -17.26054 21.33021 1.000 19.94176  ? 126 HIS A O    1 
ATOM   1920 C CB   . HIS A 1 129 ? 42.38808 -14.84445 22.58972 1.000 19.13114  ? 126 HIS A CB   1 
ATOM   1921 C CG   . HIS A 1 129 ? 42.72486 -14.59988 24.02782 1.000 20.42185  ? 126 HIS A CG   1 
ATOM   1922 N ND1  . HIS A 1 129 ? 43.07948 -15.61614 24.88936 1.000 21.51769  ? 126 HIS A ND1  1 
ATOM   1923 C CD2  . HIS A 1 129 ? 42.79998 -13.45339 24.74712 1.000 21.81761  ? 126 HIS A CD2  1 
ATOM   1924 C CE1  . HIS A 1 129 ? 43.35373 -15.10835 26.07797 1.000 23.51421  ? 126 HIS A CE1  1 
ATOM   1925 N NE2  . HIS A 1 129 ? 43.19117 -13.79796 26.01949 1.000 24.08592  ? 126 HIS A NE2  1 
ATOM   1926 H H    . HIS A 1 129 ? 42.42117 -14.74123 20.11895 1.000 22.17384  ? 126 HIS A H    1 
ATOM   1927 H HA   . HIS A 1 129 ? 44.19581 -14.17484 21.92362 1.000 24.04863  ? 126 HIS A HA   1 
ATOM   1928 H HB2  . HIS A 1 129 ? 41.82152 -14.11725 22.28792 1.000 22.97635  ? 126 HIS A HB2  1 
ATOM   1929 H HB3  . HIS A 1 129 ? 41.90682 -15.68484 22.53453 1.000 22.97635  ? 126 HIS A HB3  1 
ATOM   1930 H HD2  . HIS A 1 129 ? 42.62059 -12.59481 24.43802 1.000 26.20011  ? 126 HIS A HD2  1 
ATOM   1931 H HE1  . HIS A 1 129 ? 43.61650 -15.59098 26.82825 1.000 28.23603  ? 126 HIS A HE1  1 
ATOM   1932 H HE2  . HIS A 1 129 ? 43.31065 -13.24987 26.67135 1.000 28.92208  ? 126 HIS A HE2  1 
ATOM   1933 N N    . PRO A 1 130 ? 45.38998 -16.25773 22.76511 1.000 19.55004  ? 127 PRO A N    1 
ATOM   1934 C CA   . PRO A 1 130 ? 46.11149 -17.52560 23.01318 1.000 21.59205  ? 127 PRO A CA   1 
ATOM   1935 C C    . PRO A 1 130 ? 45.20442 -18.68153 23.38212 1.000 22.53801  ? 127 PRO A C    1 
ATOM   1936 O O    . PRO A 1 130 ? 45.47492 -19.82666 22.99247 1.000 24.57229  ? 127 PRO A O    1 
ATOM   1937 C CB   . PRO A 1 130 ? 47.06774 -17.17385 24.16248 1.000 23.59007  ? 127 PRO A CB   1 
ATOM   1938 C CG   . PRO A 1 130 ? 47.29473 -15.70194 24.01539 1.000 25.67969  ? 127 PRO A CG   1 
ATOM   1939 C CD   . PRO A 1 130 ? 46.00915 -15.11182 23.45475 1.000 22.44497  ? 127 PRO A CD   1 
ATOM   1940 H HA   . PRO A 1 130 ? 46.62910 -17.76097 22.22732 1.000 25.92944  ? 127 PRO A HA   1 
ATOM   1941 H HB2  . PRO A 1 130 ? 46.65411 -17.38058 25.01517 1.000 28.32706  ? 127 PRO A HB2  1 
ATOM   1942 H HB3  . PRO A 1 130 ? 47.89769 -17.66699 24.06812 1.000 28.32706  ? 127 PRO A HB3  1 
ATOM   1943 H HG2  . PRO A 1 130 ? 47.49510 -15.31755 24.88314 1.000 30.83461  ? 127 PRO A HG2  1 
ATOM   1944 H HG3  . PRO A 1 130 ? 48.03346 -15.54820 23.40586 1.000 30.83461  ? 127 PRO A HG3  1 
ATOM   1945 H HD2  . PRO A 1 130 ? 45.43754 -14.78697 24.16794 1.000 26.95295  ? 127 PRO A HD2  1 
ATOM   1946 H HD3  . PRO A 1 130 ? 46.20092 -14.39455 22.83052 1.000 26.95295  ? 127 PRO A HD3  1 
ATOM   1947 N N    . LEU A 1 131 ? 44.12174 -18.41641 24.10936 1.000 22.45038  ? 128 LEU A N    1 
ATOM   1948 C CA   . LEU A 1 131 ? 43.21647 -19.47687 24.53237 1.000 24.73697  ? 128 LEU A CA   1 
ATOM   1949 C C    . LEU A 1 131 ? 42.34488 -19.99896 23.40375 1.000 24.98207  ? 128 LEU A C    1 
ATOM   1950 O O    . LEU A 1 131 ? 41.70509 -21.03841 23.57433 1.000 25.66916  ? 128 LEU A O    1 
ATOM   1951 C CB   . LEU A 1 131 ? 42.32209 -18.97631 25.66862 1.000 25.69074  ? 128 LEU A CB   1 
ATOM   1952 C CG   . LEU A 1 131 ? 43.02832 -18.70272 27.00465 1.000 32.66727  ? 128 LEU A CG   1 
ATOM   1953 C CD1  . LEU A 1 131 ? 42.06224 -18.09172 28.00648 1.000 35.02764  ? 128 LEU A CD1  1 
ATOM   1954 C CD2  . LEU A 1 131 ? 43.63784 -19.97767 27.56474 1.000 39.74100  ? 128 LEU A CD2  1 
ATOM   1955 H H    . LEU A 1 131 ? 43.89025 -17.63028 24.37014 1.000 26.95943  ? 128 LEU A H    1 
ATOM   1956 H HA   . LEU A 1 131 ? 43.74893 -20.21665 24.86420 1.000 29.70334  ? 128 LEU A HA   1 
ATOM   1957 H HB2  . LEU A 1 131 ? 41.90911 -18.14545 25.38574 1.000 30.84787  ? 128 LEU A HB2  1 
ATOM   1958 H HB3  . LEU A 1 131 ? 41.64026 -19.64585 25.83511 1.000 30.84787  ? 128 LEU A HB3  1 
ATOM   1959 H HG   . LEU A 1 131 ? 43.74668 -18.06909 26.85179 1.000 39.21971  ? 128 LEU A HG   1 
ATOM   1960 H HD11 . LEU A 1 131 ? 42.52910 -17.93960 28.84302 1.000 42.05215  ? 128 LEU A HD11 1 
ATOM   1961 H HD12 . LEU A 1 131 ? 41.73213 -17.25041 27.65417 1.000 42.05215  ? 128 LEU A HD12 1 
ATOM   1962 H HD13 . LEU A 1 131 ? 41.32334 -18.70432 28.14669 1.000 42.05215  ? 128 LEU A HD13 1 
ATOM   1963 H HD21 . LEU A 1 131 ? 43.93752 -19.81222 28.47233 1.000 47.70819  ? 128 LEU A HD21 1 
ATOM   1964 H HD22 . LEU A 1 131 ? 42.96592 -20.67724 27.56061 1.000 47.70819  ? 128 LEU A HD22 1 
ATOM   1965 H HD23 . LEU A 1 131 ? 44.38997 -20.23817 27.01035 1.000 47.70819  ? 128 LEU A HD23 1 
ATOM   1966 N N    . ALA A 1 132 ? 42.31010 -19.31988 22.26333 1.000 21.67859  ? 129 ALA A N    1 
ATOM   1967 C CA   . ALA A 1 132 ? 41.53719 -19.76388 21.11105 1.000 24.15408  ? 129 ALA A CA   1 
ATOM   1968 C C    . ALA A 1 132 ? 42.40170 -20.38152 20.01779 1.000 22.90610  ? 129 ALA A C    1 
ATOM   1969 O O    . ALA A 1 132 ? 41.87362 -20.76501 18.97237 1.000 22.92103  ? 129 ALA A O    1 
ATOM   1970 C CB   . ALA A 1 132 ? 40.74053 -18.58625 20.53237 1.000 24.10253  ? 129 ALA A CB   1 
ATOM   1971 H H    . ALA A 1 132 ? 42.73472 -18.58395 22.13024 1.000 26.03329  ? 129 ALA A H    1 
ATOM   1972 H HA   . ALA A 1 132 ? 40.90597 -20.43985 21.40349 1.000 29.00388  ? 129 ALA A HA   1 
ATOM   1973 H HB1  . ALA A 1 132 ? 40.22421 -18.89732 19.77241 1.000 28.94202  ? 129 ALA A HB1  1 
ATOM   1974 H HB2  . ALA A 1 132 ? 40.14638 -18.24030 21.21663 1.000 28.94202  ? 129 ALA A HB2  1 
ATOM   1975 H HB3  . ALA A 1 132 ? 41.35931 -17.89429 20.25093 1.000 28.94202  ? 129 ALA A HB3  1 
ATOM   1976 N N    . LYS A 1 133 ? 43.70703 -20.51527 20.24461 1.000 21.35586  ? 130 LYS A N    1 
ATOM   1977 C CA   . LYS A 1 133 ? 44.59533 -21.01822 19.20228 1.000 24.40152  ? 130 LYS A CA   1 
ATOM   1978 C C    . LYS A 1 133 ? 44.20261 -22.42125 18.75889 1.000 25.25435  ? 130 LYS A C    1 
ATOM   1979 O O    . LYS A 1 133 ? 44.04621 -22.68440 17.55699 1.000 24.17336  ? 130 LYS A O    1 
ATOM   1980 C CB   . LYS A 1 133 ? 46.03748 -21.00505 19.69771 1.000 25.47431  ? 130 LYS A CB   1 
ATOM   1981 C CG   . LYS A 1 133 ? 47.02224 -21.69721 18.74591 1.000 25.54237  ? 130 LYS A CG   1 
ATOM   1982 C CD   . LYS A 1 133 ? 48.45539 -21.57388 19.24046 1.000 28.92178  ? 130 LYS A CD   1 
ATOM   1983 C CE   . LYS A 1 133 ? 49.41931 -22.24335 18.26957 1.000 30.16512  ? 130 LYS A CE   1 
ATOM   1984 N NZ   . LYS A 1 133 ? 50.15129 -23.36000 18.90158 1.000 40.33817  ? 130 LYS A NZ   1 
ATOM   1985 H H    . LYS A 1 133 ? 44.09917 -20.32382 20.98567 1.000 25.64601  ? 130 LYS A H    1 
ATOM   1986 H HA   . LYS A 1 133 ? 44.52646 -20.43134 18.43304 1.000 29.30081  ? 130 LYS A HA   1 
ATOM   1987 H HB2  . LYS A 1 133 ? 46.32338 -20.08399 19.80173 1.000 30.58815  ? 130 LYS A HB2  1 
ATOM   1988 H HB3  . LYS A 1 133 ? 46.07840 -21.46356 20.55152 1.000 30.58815  ? 130 LYS A HB3  1 
ATOM   1989 H HG2  . LYS A 1 133 ? 46.80101 -22.63964 18.68432 1.000 30.66983  ? 130 LYS A HG2  1 
ATOM   1990 H HG3  . LYS A 1 133 ? 46.96559 -21.28518 17.86961 1.000 30.66983  ? 130 LYS A HG3  1 
ATOM   1991 H HD2  . LYS A 1 133 ? 48.69358 -20.63646 19.31412 1.000 34.72511  ? 130 LYS A HD2  1 
ATOM   1992 H HD3  . LYS A 1 133 ? 48.53862 -22.00623 20.10478 1.000 34.72511  ? 130 LYS A HD3  1 
ATOM   1993 H HE2  . LYS A 1 133 ? 48.92049 -22.59564 17.51593 1.000 36.21713  ? 130 LYS A HE2  1 
ATOM   1994 H HE3  . LYS A 1 133 ? 50.06793 -21.59085 17.96227 1.000 36.21713  ? 130 LYS A HE3  1 
ATOM   1995 H HZ1  . LYS A 1 133 ? 50.71507 -23.72400 18.31697 1.000 48.42479  ? 130 LYS A HZ1  1 
ATOM   1996 H HZ2  . LYS A 1 133 ? 50.61323 -23.06339 19.60210 1.000 48.42479  ? 130 LYS A HZ2  1 
ATOM   1997 H HZ3  . LYS A 1 133 ? 49.57808 -23.98292 19.17636 1.000 48.42479  ? 130 LYS A HZ3  1 
ATOM   1998 N N    . ASP A 1 134 ? 44.04677 -23.34012 19.71748 1.000 25.63343  ? 131 ASP A N    1 
ATOM   1999 C CA   . ASP A 1 134 ? 43.76854 -24.72798 19.36364 1.000 28.03639  ? 131 ASP A CA   1 
ATOM   2000 C C    . ASP A 1 134 ? 42.50555 -24.83837 18.52391 1.000 28.25463  ? 131 ASP A C    1 
ATOM   2001 O O    . ASP A 1 134 ? 42.45876 -25.59557 17.54530 1.000 25.79732  ? 131 ASP A O    1 
ATOM   2002 C CB   . ASP A 1 134 ? 43.64343 -25.57781 20.62607 1.000 31.92332  ? 131 ASP A CB   1 
ATOM   2003 C CG   . ASP A 1 134 ? 44.97878 -25.77408 21.33500 1.000 34.60956  ? 131 ASP A CG   1 
ATOM   2004 O OD1  . ASP A 1 134 ? 46.03197 -25.64688 20.66768 1.000 34.34576  ? 131 ASP A OD1  1 
ATOM   2005 O OD2  . ASP A 1 134 ? 44.96289 -26.05643 22.55434 1.000 46.82381  ? 131 ASP A OD2  1 
ATOM   2006 H H    . ASP A 1 134 ? 44.09676 -23.18632 20.56214 1.000 30.77910  ? 131 ASP A H    1 
ATOM   2007 H HA   . ASP A 1 134 ? 44.51095 -25.07071 18.84185 1.000 33.66264  ? 131 ASP A HA   1 
ATOM   2008 H HB2  . ASP A 1 134 ? 43.03674 -25.14019 21.24358 1.000 38.32697  ? 131 ASP A HB2  1 
ATOM   2009 H HB3  . ASP A 1 134 ? 43.29900 -26.45232 20.38629 1.000 38.32697  ? 131 ASP A HB3  1 
ATOM   2010 N N    . LYS A 1 135 ? 41.47080 -24.08727 18.89294 1.000 26.63401  ? 132 LYS A N    1 
ATOM   2011 C CA   . LYS A 1 135 ? 40.22668 -24.10667 18.13417 1.000 28.95424  ? 132 LYS A CA   1 
ATOM   2012 C C    . LYS A 1 135 ? 40.44978 -23.60541 16.71311 1.000 25.97675  ? 132 LYS A C    1 
ATOM   2013 O O    . LYS A 1 135 ? 39.97741 -24.21218 15.74276 1.000 24.54932  ? 132 LYS A O    1 
ATOM   2014 C CB   . LYS A 1 135 ? 39.17095 -23.25508 18.85237 1.000 35.24509  ? 132 LYS A CB   1 
ATOM   2015 C CG   . LYS A 1 135 ? 37.81818 -23.23206 18.17527 1.000 53.12709  ? 132 LYS A CG   1 
ATOM   2016 C CD   . LYS A 1 135 ? 36.80277 -24.07792 18.93387 1.000 88.48524  ? 132 LYS A CD   1 
ATOM   2017 C CE   . LYS A 1 135 ? 35.47030 -24.11256 18.19553 1.000 104.94528 ? 132 LYS A CE   1 
ATOM   2018 N NZ   . LYS A 1 135 ? 34.34816 -24.48608 19.09318 1.000 88.08956  ? 132 LYS A NZ   1 
ATOM   2019 H H    . LYS A 1 135 ? 41.46387 -23.56186 19.57375 1.000 31.97980  ? 132 LYS A H    1 
ATOM   2020 H HA   . LYS A 1 135 ? 39.89773 -25.01775 18.08305 1.000 34.76407  ? 132 LYS A HA   1 
ATOM   2021 H HB2  . LYS A 1 135 ? 39.04506 -23.60854 19.74687 1.000 42.31309  ? 132 LYS A HB2  1 
ATOM   2022 H HB3  . LYS A 1 135 ? 39.49102 -22.34060 18.89901 1.000 42.31309  ? 132 LYS A HB3  1 
ATOM   2023 H HG2  . LYS A 1 135 ? 37.49088 -22.31958 18.14124 1.000 63.77149  ? 132 LYS A HG2  1 
ATOM   2024 H HG3  . LYS A 1 135 ? 37.90192 -23.58819 17.27690 1.000 63.77149  ? 132 LYS A HG3  1 
ATOM   2025 H HD2  . LYS A 1 135 ? 37.13357 -24.98613 19.01522 1.000 106.20127 ? 132 LYS A HD2  1 
ATOM   2026 H HD3  . LYS A 1 135 ? 36.65729 -23.69771 19.81431 1.000 106.20127 ? 132 LYS A HD3  1 
ATOM   2027 H HE2  . LYS A 1 135 ? 35.28546 -23.23385 17.82864 1.000 125.95332 ? 132 LYS A HE2  1 
ATOM   2028 H HE3  . LYS A 1 135 ? 35.51786 -24.76704 17.48118 1.000 125.95332 ? 132 LYS A HE3  1 
ATOM   2029 H HZ1  . LYS A 1 135 ? 33.58770 -24.51973 18.63203 1.000 105.72646 ? 132 LYS A HZ1  1 
ATOM   2030 H HZ2  . LYS A 1 135 ? 34.50139 -25.28413 19.45616 1.000 105.72646 ? 132 LYS A HZ2  1 
ATOM   2031 H HZ3  . LYS A 1 135 ? 34.26521 -23.88413 19.74347 1.000 105.72646 ? 132 LYS A HZ3  1 
ATOM   2032 N N    . MET A 1 136 ? 41.15836 -22.48512 16.57263 1.000 23.55414  ? 133 MET A N    1 
ATOM   2033 C CA   . MET A 1 136 ? 41.38385 -21.92145 15.24703 1.000 24.03007  ? 133 MET A CA   1 
ATOM   2034 C C    . MET A 1 136 ? 42.17909 -22.86621 14.35499 1.000 21.50823  ? 133 MET A C    1 
ATOM   2035 O O    . MET A 1 136 ? 41.97850 -22.89499 13.13310 1.000 22.42048  ? 133 MET A O    1 
ATOM   2036 C CB   . MET A 1 136 ? 42.12670 -20.60206 15.38558 1.000 20.46403  ? 133 MET A CB   1 
ATOM   2037 C CG   . MET A 1 136 ? 42.23639 -19.77562 14.12301 1.000 20.25151  ? 133 MET A CG   1 
ATOM   2038 S SD   . MET A 1 136 ? 40.66111 -19.15052 13.62604 1.000 23.61367  ? 133 MET A SD   1 
ATOM   2039 C CE   . MET A 1 136 ? 41.03877 -18.30804 12.09247 1.000 27.98103  ? 133 MET A CE   1 
ATOM   2040 H H    . MET A 1 136 ? 41.51266 -22.04071 17.21805 1.000 28.28395  ? 133 MET A H    1 
ATOM   2041 H HA   . MET A 1 136 ? 40.52342 -21.75647 14.83070 1.000 28.85506  ? 133 MET A HA   1 
ATOM   2042 H HB2  . MET A 1 136 ? 41.66500 -20.06066 16.04483 1.000 24.57582  ? 133 MET A HB2  1 
ATOM   2043 H HB3  . MET A 1 136 ? 43.02967 -20.79123 15.68518 1.000 24.57582  ? 133 MET A HB3  1 
ATOM   2044 H HG2  . MET A 1 136 ? 42.82804 -19.02345 14.28139 1.000 24.32080  ? 133 MET A HG2  1 
ATOM   2045 H HG3  . MET A 1 136 ? 42.58641 -20.32792 13.40653 1.000 24.32080  ? 133 MET A HG3  1 
ATOM   2046 H HE1  . MET A 1 136 ? 40.21146 -18.00561 11.68627 1.000 33.59622  ? 133 MET A HE1  1 
ATOM   2047 H HE2  . MET A 1 136 ? 41.61118 -17.54827 12.28221 1.000 33.59622  ? 133 MET A HE2  1 
ATOM   2048 H HE3  . MET A 1 136 ? 41.49354 -18.92434 11.49728 1.000 33.59622  ? 133 MET A HE3  1 
ATOM   2049 N N    . MET A 1 137 ? 43.09894 -23.62256 14.93726 1.000 22.19112  ? 134 MET A N    1 
ATOM   2050 C CA   . MET A 1 137 ? 44.04303 -24.42650 14.17838 1.000 22.60044  ? 134 MET A CA   1 
ATOM   2051 C C    . MET A 1 137 ? 43.56216 -25.84630 13.93848 1.000 23.33474  ? 134 MET A C    1 
ATOM   2052 O O    . MET A 1 137 ? 44.32272 -26.65697 13.40080 1.000 22.30985  ? 134 MET A O    1 
ATOM   2053 C CB   . MET A 1 137 ? 45.38956 -24.45452 14.90096 1.000 22.48867  ? 134 MET A CB   1 
ATOM   2054 C CG   . MET A 1 137 ? 46.12815 -23.12989 14.85088 1.000 20.90944  ? 134 MET A CG   1 
ATOM   2055 S SD   . MET A 1 137 ? 46.51189 -22.64822 13.17116 1.000 25.06610  ? 134 MET A SD   1 
ATOM   2056 C CE   . MET A 1 137 ? 47.69320 -23.92454 12.72311 1.000 23.75760  ? 134 MET A CE   1 
ATOM   2057 H H    . MET A 1 137 ? 43.19759 -23.68759 15.78911 1.000 26.64832  ? 134 MET A H    1 
ATOM   2058 H HA   . MET A 1 137 ? 44.17142 -24.00488 13.31429 1.000 27.13950  ? 134 MET A HA   1 
ATOM   2059 H HB2  . MET A 1 137 ? 45.24013 -24.67693 15.83321 1.000 27.00539  ? 134 MET A HB2  1 
ATOM   2060 H HB3  . MET A 1 137 ? 45.95370 -25.12573 14.48606 1.000 27.00539  ? 134 MET A HB3  1 
ATOM   2061 H HG2  . MET A 1 137 ? 45.57363 -22.43921 15.24632 1.000 25.11031  ? 134 MET A HG2  1 
ATOM   2062 H HG3  . MET A 1 137 ? 46.96061 -23.20892 15.34247 1.000 25.11031  ? 134 MET A HG3  1 
ATOM   2063 H HE1  . MET A 1 137 ? 48.07807 -23.70938 11.85912 1.000 28.52810  ? 134 MET A HE1  1 
ATOM   2064 H HE2  . MET A 1 137 ? 48.39061 -23.95975 13.39638 1.000 28.52810  ? 134 MET A HE2  1 
ATOM   2065 H HE3  . MET A 1 137 ? 47.23411 -24.77780 12.67749 1.000 28.52810  ? 134 MET A HE3  1 
ATOM   2066 N N    . ASN A 1 138 ? 42.32628 -26.16373 14.31572 1.000 24.96926  ? 135 ASN A N    1 
ATOM   2067 C CA   . ASN A 1 138 ? 41.77345 -27.48783 14.06230 1.000 27.25038  ? 135 ASN A CA   1 
ATOM   2068 C C    . ASN A 1 138 ? 41.75717 -27.75951 12.56256 1.000 24.96760  ? 135 ASN A C    1 
ATOM   2069 O O    . ASN A 1 138 ? 41.04342 -27.08559 11.81060 1.000 23.58430  ? 135 ASN A O    1 
ATOM   2070 C CB   . ASN A 1 138 ? 40.36749 -27.59672 14.65158 1.000 33.57444  ? 135 ASN A CB   1 
ATOM   2071 C CG   . ASN A 1 138 ? 39.80357 -29.00583 14.56348 1.000 41.03947  ? 135 ASN A CG   1 
ATOM   2072 O OD1  . ASN A 1 138 ? 40.53835 -29.97036 14.37593 1.000 49.51045  ? 135 ASN A OD1  1 
ATOM   2073 N ND2  . ASN A 1 138 ? 38.49394 -29.12574 14.70010 1.000 63.03637  ? 135 ASN A ND2  1 
ATOM   2074 H H    . ASN A 1 138 ? 41.78836 -25.62850 14.72041 1.000 29.98209  ? 135 ASN A H    1 
ATOM   2075 H HA   . ASN A 1 138 ? 42.32165 -28.16416 14.49002 1.000 32.71943  ? 135 ASN A HA   1 
ATOM   2076 H HB2  . ASN A 1 138 ? 40.39584 -27.34242 15.58722 1.000 40.30831  ? 135 ASN A HB2  1 
ATOM   2077 H HB3  . ASN A 1 138 ? 39.77341 -27.00439 14.16464 1.000 40.30831  ? 135 ASN A HB3  1 
ATOM   2078 H HD21 . ASN A 1 138 ? 38.12652 -29.90216 14.65803 1.000 75.66263  ? 135 ASN A HD21 1 
ATOM   2079 H HD22 . ASN A 1 138 ? 38.00953 -28.42731 14.83102 1.000 75.66263  ? 135 ASN A HD22 1 
ATOM   2080 N N    . GLY A 1 139 ? 42.55166 -28.73015 12.11488 1.000 25.28560  ? 136 GLY A N    1 
ATOM   2081 C CA   . GLY A 1 139 ? 42.65786 -29.05748 10.70659 1.000 24.97069  ? 136 GLY A CA   1 
ATOM   2082 C C    . GLY A 1 139 ? 43.83166 -28.43082 9.97674  1.000 24.57731  ? 136 GLY A C    1 
ATOM   2083 O O    . GLY A 1 139 ? 44.11646 -28.82338 8.83366  1.000 23.91119  ? 136 GLY A O    1 
ATOM   2084 H H    A GLY A 1 139 ? 43.04574 -29.21873 12.62161 0.550 30.36171  ? 136 GLY A H    1 
ATOM   2085 H H    B GLY A 1 139 ? 43.04574 -29.21873 12.62161 0.450 30.36171  ? 136 GLY A H    1 
ATOM   2086 H HA2  . GLY A 1 139 ? 42.73877 -30.02014 10.61928 1.000 29.98381  ? 136 GLY A HA2  1 
ATOM   2087 H HA3  . GLY A 1 139 ? 41.84683 -28.76701 10.26076 1.000 29.98381  ? 136 GLY A HA3  1 
ATOM   2088 N N    . GLY A 1 140 ? 44.51418 -27.47160 10.59048 1.000 21.86916  ? 137 GLY A N    1 
ATOM   2089 C CA   . GLY A 1 140 ? 45.65374 -26.84678 9.94813  1.000 22.29927  ? 137 GLY A CA   1 
ATOM   2090 C C    . GLY A 1 140 ? 45.31466 -26.01173 8.73238  1.000 22.38277  ? 137 GLY A C    1 
ATOM   2091 O O    . GLY A 1 140 ? 46.11913 -25.92519 7.80782  1.000 23.66024  ? 137 GLY A O    1 
ATOM   2092 H H    . GLY A 1 140 ? 44.33625 -27.16814 11.37524 1.000 26.26198  ? 137 GLY A H    1 
ATOM   2093 H HA2  . GLY A 1 140 ? 46.09545 -26.26947 10.59038 1.000 26.77810  ? 137 GLY A HA2  1 
ATOM   2094 H HA3  . GLY A 1 140 ? 46.27231 -27.53969 9.66859  1.000 26.77810  ? 137 GLY A HA3  1 
ATOM   2095 N N    . HIS A 1 141 ? 44.14549 -25.38369 8.71077  1.000 19.75775  ? 138 HIS A N    1 
ATOM   2096 C CA   . HIS A 1 141 ? 43.71994 -24.62413 7.54109  1.000 21.57016  ? 138 HIS A CA   1 
ATOM   2097 C C    . HIS A 1 141 ? 44.30942 -23.22352 7.49083  1.000 22.59313  ? 138 HIS A C    1 
ATOM   2098 O O    . HIS A 1 141 ? 44.27083 -22.59034 6.43031  1.000 22.03735  ? 138 HIS A O    1 
ATOM   2099 C CB   . HIS A 1 141 ? 42.19672 -24.54159 7.50899  1.000 23.18599  ? 138 HIS A CB   1 
ATOM   2100 C CG   . HIS A 1 141 ? 41.52923 -25.86736 7.33680  1.000 23.50250  ? 138 HIS A CG   1 
ATOM   2101 N ND1  . HIS A 1 141 ? 41.58123 -26.57709 6.15656  1.000 23.17596  ? 138 HIS A ND1  1 
ATOM   2102 C CD2  . HIS A 1 141 ? 40.79763 -26.61486 8.19543  1.000 25.95594  ? 138 HIS A CD2  1 
ATOM   2103 C CE1  . HIS A 1 141 ? 40.89169 -27.69591 6.28968  1.000 26.14883  ? 138 HIS A CE1  1 
ATOM   2104 N NE2  . HIS A 1 141 ? 40.41795 -27.74937 7.52159  1.000 25.53338  ? 138 HIS A NE2  1 
ATOM   2105 H H    . HIS A 1 141 ? 43.58047 -25.38127 9.35912  1.000 23.72829  ? 138 HIS A H    1 
ATOM   2106 H HA   . HIS A 1 141 ? 44.01749 -25.09048 6.74429  1.000 25.90317  ? 138 HIS A HA   1 
ATOM   2107 H HB2  . HIS A 1 141 ? 41.88679 -24.15971 8.34506  1.000 27.84217  ? 138 HIS A HB2  1 
ATOM   2108 H HB3  . HIS A 1 141 ? 41.92997 -23.97650 6.76709  1.000 27.84217  ? 138 HIS A HB3  1 
ATOM   2109 H HD2  . HIS A 1 141 ? 40.59085 -26.40044 9.07644  1.000 31.16611  ? 138 HIS A HD2  1 
ATOM   2110 H HE1  . HIS A 1 141 ? 40.76185 -28.33694 5.62853  1.000 31.39758  ? 138 HIS A HE1  1 
ATOM   2111 H HE2  . HIS A 1 141 ? 39.94780 -28.39092 7.84865  0.282 30.65904  ? 138 HIS A HE2  1 
ATOM   2112 N N    . TYR A 1 142 ? 44.85007 -22.73311 8.59805  1.000 19.55452  ? 139 TYR A N    1 
ATOM   2113 C CA   . TYR A 1 142 ? 45.53180 -21.45079 8.65428  1.000 21.08457  ? 139 TYR A CA   1 
ATOM   2114 C C    . TYR A 1 142 ? 46.94368 -21.66099 9.18672  1.000 23.06453  ? 139 TYR A C    1 
ATOM   2115 O O    . TYR A 1 142 ? 47.27940 -22.70927 9.73570  1.000 23.03632  ? 139 TYR A O    1 
ATOM   2116 C CB   . TYR A 1 142 ? 44.78850 -20.45125 9.56066  1.000 21.42731  ? 139 TYR A CB   1 
ATOM   2117 C CG   . TYR A 1 142 ? 43.31313 -20.29915 9.25998  1.000 22.16967  ? 139 TYR A CG   1 
ATOM   2118 C CD1  . TYR A 1 142 ? 42.37718 -21.13021 9.85665  1.000 21.66556  ? 139 TYR A CD1  1 
ATOM   2119 C CD2  . TYR A 1 142 ? 42.86130 -19.32980 8.38925  1.000 23.12644  ? 139 TYR A CD2  1 
ATOM   2120 C CE1  . TYR A 1 142 ? 41.04013 -21.01287 9.58753  1.000 22.02538  ? 139 TYR A CE1  1 
ATOM   2121 C CE2  . TYR A 1 142 ? 41.52091 -19.20023 8.11485  1.000 22.62608  ? 139 TYR A CE2  1 
ATOM   2122 C CZ   . TYR A 1 142 ? 40.61381 -20.03929 8.71257  1.000 23.66300  ? 139 TYR A CZ   1 
ATOM   2123 O OH   . TYR A 1 142 ? 39.27409 -19.90455 8.43727  1.000 24.59893  ? 139 TYR A OH   1 
ATOM   2124 H H    A TYR A 1 142 ? 44.83335 -23.14044 9.35528  0.530 23.48441  ? 139 TYR A H    1 
ATOM   2125 H H    B TYR A 1 142 ? 44.83335 -23.14044 9.35528  0.470 23.48441  ? 139 TYR A H    1 
ATOM   2126 H HA   . TYR A 1 142 ? 45.57351 -21.07614 7.76053  1.000 25.32047  ? 139 TYR A HA   1 
ATOM   2127 H HB2  . TYR A 1 142 ? 44.86970 -20.74984 10.47998 1.000 25.73175  ? 139 TYR A HB2  1 
ATOM   2128 H HB3  . TYR A 1 142 ? 45.19877 -19.57831 9.45790  1.000 25.73175  ? 139 TYR A HB3  1 
ATOM   2129 H HD1  . TYR A 1 142 ? 42.66458 -21.78272 10.45375 1.000 26.01765  ? 139 TYR A HD1  1 
ATOM   2130 H HD2  . TYR A 1 142 ? 43.47094 -18.75697 7.98292  1.000 27.77071  ? 139 TYR A HD2  1 
ATOM   2131 H HE1  . TYR A 1 142 ? 40.42706 -21.58406 9.99099  1.000 26.44943  ? 139 TYR A HE1  1 
ATOM   2132 H HE2  . TYR A 1 142 ? 41.22847 -18.54409 7.52421  1.000 27.17028  ? 139 TYR A HE2  1 
ATOM   2133 H HH   . TYR A 1 142 ? 39.14588 -19.22595 7.95909  1.000 29.53769  ? 139 TYR A HH   1 
ATOM   2134 N N    . THR A 1 143 ? 47.76074 -20.62697 9.05099  1.000 21.64355  ? 140 THR A N    1 
ATOM   2135 C CA   . THR A 1 143 ? 49.07768 -20.55578 9.66419  1.000 23.53203  ? 140 THR A CA   1 
ATOM   2136 C C    . THR A 1 143 ? 49.01753 -19.55689 10.80803 1.000 24.26264  ? 140 THR A C    1 
ATOM   2137 O O    . THR A 1 143 ? 48.54485 -18.42733 10.63365 1.000 24.28271  ? 140 THR A O    1 
ATOM   2138 C CB   . THR A 1 143 ? 50.13351 -20.15560 8.63585  1.000 26.27622  ? 140 THR A CB   1 
ATOM   2139 O OG1  . THR A 1 143 ? 50.20746 -21.19179 7.64802  1.000 26.92036  ? 140 THR A OG1  1 
ATOM   2140 C CG2  . THR A 1 143 ? 51.47981 -19.99338 9.28214  1.000 27.47001  ? 140 THR A CG2  1 
ATOM   2141 H H    . THR A 1 143 ? 47.56659 -19.92725 8.59022  1.000 25.99124  ? 140 THR A H    1 
ATOM   2142 H HA   . THR A 1 143 ? 49.33579 -21.41872 10.02420 1.000 28.25742  ? 140 THR A HA   1 
ATOM   2143 H HB   . THR A 1 143 ? 49.89760 -19.30775 8.22793  1.000 31.55044  ? 140 THR A HB   1 
ATOM   2144 H HG1  . THR A 1 143 ? 50.78362 -20.99608 7.06893  1.000 32.32342  ? 140 THR A HG1  1 
ATOM   2145 H HG21 . THR A 1 143 ? 52.16830 -19.92617 8.60217  1.000 32.98299  ? 140 THR A HG21 1 
ATOM   2146 H HG22 . THR A 1 143 ? 51.49293 -19.18895 9.82401  1.000 32.98299  ? 140 THR A HG22 1 
ATOM   2147 H HG23 . THR A 1 143 ? 51.67020 -20.75755 9.84845  1.000 32.98299  ? 140 THR A HG23 1 
ATOM   2148 N N    . TYR A 1 144 ? 49.47293 -19.97873 11.97960 1.000 22.98689  ? 141 TYR A N    1 
ATOM   2149 C CA   . TYR A 1 144 ? 49.28256 -19.19093 13.19105 1.000 23.13535  ? 141 TYR A CA   1 
ATOM   2150 C C    . TYR A 1 144 ? 50.40284 -18.18730 13.40143 1.000 24.51992  ? 141 TYR A C    1 
ATOM   2151 O O    . TYR A 1 144 ? 51.56489 -18.47283 13.12572 1.000 25.68741  ? 141 TYR A O    1 
ATOM   2152 C CB   . TYR A 1 144 ? 49.19661 -20.09969 14.41620 1.000 23.82275  ? 141 TYR A CB   1 
ATOM   2153 C CG   . TYR A 1 144 ? 48.56136 -19.41095 15.59460 1.000 22.63779  ? 141 TYR A CG   1 
ATOM   2154 C CD1  . TYR A 1 144 ? 47.18635 -19.19272 15.63080 1.000 23.38975  ? 141 TYR A CD1  1 
ATOM   2155 C CD2  . TYR A 1 144 ? 49.32481 -18.94550 16.65043 1.000 26.47915  ? 141 TYR A CD2  1 
ATOM   2156 C CE1  . TYR A 1 144 ? 46.59187 -18.54988 16.70224 1.000 23.06198  ? 141 TYR A CE1  1 
ATOM   2157 C CE2  . TYR A 1 144 ? 48.73791 -18.29701 17.72460 1.000 25.27068  ? 141 TYR A CE2  1 
ATOM   2158 C CZ   . TYR A 1 144 ? 47.37453 -18.10407 17.74230 1.000 23.89328  ? 141 TYR A CZ   1 
ATOM   2159 O OH   . TYR A 1 144 ? 46.78282 -17.47531 18.80423 1.000 24.18460  ? 141 TYR A OH   1 
ATOM   2160 H H    . TYR A 1 144 ? 49.89566 -20.71793 12.09995 1.000 27.60325  ? 141 TYR A H    1 
ATOM   2161 H HA   . TYR A 1 144 ? 48.45442 -18.69518 13.09451 1.000 27.78140  ? 141 TYR A HA   1 
ATOM   2162 H HB2  . TYR A 1 144 ? 48.66170 -20.87859 14.19687 1.000 28.60628  ? 141 TYR A HB2  1 
ATOM   2163 H HB3  . TYR A 1 144 ? 50.09140 -20.37309 14.67213 1.000 28.60628  ? 141 TYR A HB3  1 
ATOM   2164 H HD1  . TYR A 1 144 ? 46.65861 -19.48406 14.92263 1.000 28.08668  ? 141 TYR A HD1  1 
ATOM   2165 H HD2  . TYR A 1 144 ? 50.24638 -19.06996 16.63878 1.000 31.79396  ? 141 TYR A HD2  1 
ATOM   2166 H HE1  . TYR A 1 144 ? 45.67111 -18.42026 16.71922 1.000 27.69336  ? 141 TYR A HE1  1 
ATOM   2167 H HE2  . TYR A 1 144 ? 49.26203 -17.99344 18.43032 1.000 30.34379  ? 141 TYR A HE2  1 
ATOM   2168 H HH   . TYR A 1 144 ? 45.95151 -17.43848 18.68949 1.000 29.04050  ? 141 TYR A HH   1 
ATOM   2169 N N    A SER A 1 145 ? 50.04400 -17.01964 13.92419 0.900 24.20803  ? 142 SER A N    1 
ATOM   2170 N N    B SER A 1 145 ? 50.03830 -17.00714 13.88851 0.100 25.08728  ? 142 SER A N    1 
ATOM   2171 C CA   A SER A 1 145 ? 50.98090 -15.94336 14.19536 0.900 25.52161  ? 142 SER A CA   1 
ATOM   2172 C CA   B SER A 1 145 ? 51.00320 -15.95633 14.18027 0.100 25.52481  ? 142 SER A CA   1 
ATOM   2173 C C    A SER A 1 145 ? 50.76044 -15.45334 15.61821 0.900 25.51063  ? 142 SER A C    1 
ATOM   2174 C C    B SER A 1 145 ? 50.77134 -15.43904 15.59974 0.100 25.95600  ? 142 SER A C    1 
ATOM   2175 O O    A SER A 1 145 ? 49.63196 -15.45354 16.12129 0.900 24.63823  ? 142 SER A O    1 
ATOM   2176 O O    B SER A 1 145 ? 49.63743 -15.40776 16.08156 0.100 24.66806  ? 142 SER A O    1 
ATOM   2177 C CB   A SER A 1 145 ? 50.79617 -14.77788 13.21662 0.900 25.40359  ? 142 SER A CB   1 
ATOM   2178 C CB   B SER A 1 145 ? 50.88758 -14.81394 13.17551 0.100 25.82764  ? 142 SER A CB   1 
ATOM   2179 O OG   A SER A 1 145 ? 51.43172 -13.60442 13.69864 0.900 23.40865  ? 142 SER A OG   1 
ATOM   2180 O OG   B SER A 1 145 ? 49.65509 -14.13532 13.31039 0.100 25.51751  ? 142 SER A OG   1 
ATOM   2181 H H    A SER A 1 145 ? 49.23420 -16.82303 14.13675 0.900 29.06861  ? 142 SER A H    1 
ATOM   2182 H H    B SER A 1 145 ? 49.22505 -16.78722 14.06131 0.100 30.12372  ? 142 SER A H    1 
ATOM   2183 H HA   A SER A 1 145 ? 51.89159 -16.26614 14.10952 0.900 30.64491  ? 142 SER A HA   1 
ATOM   2184 H HA   B SER A 1 145 ? 51.90499 -16.30655 14.10944 0.100 30.64875  ? 142 SER A HA   1 
ATOM   2185 H HB2  A SER A 1 145 ? 51.18614 -15.01917 12.36186 0.900 30.50328  ? 142 SER A HB2  1 
ATOM   2186 H HB2  B SER A 1 145 ? 51.61047 -14.18578 13.32961 0.100 31.01215  ? 142 SER A HB2  1 
ATOM   2187 H HB3  A SER A 1 145 ? 49.84809 -14.60219 13.11096 0.900 30.50328  ? 142 SER A HB3  1 
ATOM   2188 H HB3  B SER A 1 145 ? 50.94946 -15.17734 12.27829 0.100 31.01215  ? 142 SER A HB3  1 
ATOM   2189 H HG   A SER A 1 145 ? 51.31304 -12.97129 13.15951 0.900 28.10937  ? 142 SER A HG   1 
ATOM   2190 H HG   B SER A 1 145 ? 49.65523 -13.67656 14.01405 0.100 30.63999  ? 142 SER A HG   1 
ATOM   2191 N N    . GLU A 1 146 ? 51.84831 -15.03236 16.26174 1.000 26.30183  ? 143 GLU A N    1 
ATOM   2192 C CA   A GLU A 1 146 ? 51.79664 -14.46380 17.60289 0.406 29.02773  ? 143 GLU A CA   1 
ATOM   2193 C CA   C GLU A 1 146 ? 51.72745 -14.45911 17.59309 0.594 29.04334  ? 143 GLU A CA   1 
ATOM   2194 C C    . GLU A 1 146 ? 51.87648 -12.93928 17.58417 1.000 29.02880  ? 143 GLU A C    1 
ATOM   2195 O O    . GLU A 1 146 ? 52.04750 -12.31704 18.63745 1.000 27.34332  ? 143 GLU A O    1 
ATOM   2196 C CB   A GLU A 1 146 ? 52.92262 -15.04181 18.46372 0.406 32.87172  ? 143 GLU A CB   1 
ATOM   2197 C CB   C GLU A 1 146 ? 52.76697 -15.08384 18.52343 0.594 32.50761  ? 143 GLU A CB   1 
ATOM   2198 C CG   A GLU A 1 146 ? 52.88925 -16.55987 18.61570 0.406 38.15903  ? 143 GLU A CG   1 
ATOM   2199 C CG   C GLU A 1 146 ? 52.63293 -16.59598 18.68069 0.594 37.82260  ? 143 GLU A CG   1 
ATOM   2200 C CD   A GLU A 1 146 ? 52.35199 -17.02212 19.97033 0.406 40.45745  ? 143 GLU A CD   1 
ATOM   2201 C CD   C GLU A 1 146 ? 53.69395 -17.19627 19.58811 0.594 42.44439  ? 143 GLU A CD   1 
ATOM   2202 O OE1  A GLU A 1 146 ? 52.27389 -16.20329 20.91128 0.406 42.01940  ? 143 GLU A OE1  1 
ATOM   2203 O OE1  C GLU A 1 146 ? 54.35987 -16.43421 20.31479 0.594 43.32049  ? 143 GLU A OE1  1 
ATOM   2204 O OE2  A GLU A 1 146 ? 52.00780 -18.21624 20.09521 0.406 44.33409  ? 143 GLU A OE2  1 
ATOM   2205 O OE2  C GLU A 1 146 ? 53.85581 -18.43241 19.57052 0.594 51.85920  ? 143 GLU A OE2  1 
ATOM   2206 H H    A GLU A 1 146 ? 52.64250 -15.06738 15.93366 0.900 31.58118  ? 143 GLU A H    1 
ATOM   2207 H HA   A GLU A 1 146 ? 50.95553 -14.71309 18.01676 0.406 34.85226  ? 143 GLU A HA   1 
ATOM   2208 H HA   C GLU A 1 146 ? 50.84083 -14.65413 17.93482 0.594 34.87099  ? 143 GLU A HA   1 
ATOM   2209 H HB2  A GLU A 1 146 ? 53.77227 -14.80673 18.05909 0.406 39.46504  ? 143 GLU A HB2  1 
ATOM   2210 H HB2  C GLU A 1 146 ? 53.65101 -14.90163 18.16824 0.594 39.02812  ? 143 GLU A HB2  1 
ATOM   2211 H HB3  A GLU A 1 146 ? 52.86052 -14.65724 19.35206 0.406 39.46504  ? 143 GLU A HB3  1 
ATOM   2212 H HB3  C GLU A 1 146 ? 52.67468 -14.68661 19.40354 0.594 39.02812  ? 143 GLU A HB3  1 
ATOM   2213 H HG2  A GLU A 1 146 ? 52.31704 -16.93168 17.92633 0.406 45.80981  ? 143 GLU A HG2  1 
ATOM   2214 H HG2  C GLU A 1 146 ? 51.76441 -16.79712 19.06295 0.594 45.40610  ? 143 GLU A HG2  1 
ATOM   2215 H HG3  A GLU A 1 146 ? 53.79086 -16.90463 18.52009 0.406 45.80981  ? 143 GLU A HG3  1 
ATOM   2216 H HG3  C GLU A 1 146 ? 52.71585 -17.01194 17.80834 0.594 45.40610  ? 143 GLU A HG3  1 
ATOM   2217 N N    . ASN A 1 147 ? 51.77124 -12.32567 16.40911 1.000 27.23703  ? 144 ASN A N    1 
ATOM   2218 C CA   . ASN A 1 147 ? 51.79767 -10.87118 16.32136 1.000 26.80703  ? 144 ASN A CA   1 
ATOM   2219 C C    . ASN A 1 147 ? 50.51691 -10.28312 16.90526 1.000 25.24246  ? 144 ASN A C    1 
ATOM   2220 O O    . ASN A 1 147 ? 49.43568 -10.87552 16.82578 1.000 23.78719  ? 144 ASN A O    1 
ATOM   2221 C CB   . ASN A 1 147 ? 51.96289 -10.42428 14.86973 1.000 27.94202  ? 144 ASN A CB   1 
ATOM   2222 C CG   . ASN A 1 147 ? 53.37845 -10.60353 14.36007 1.000 31.84787  ? 144 ASN A CG   1 
ATOM   2223 O OD1  . ASN A 1 147 ? 54.34658 -10.40002 15.08475 1.000 35.57818  ? 144 ASN A OD1  1 
ATOM   2224 N ND2  . ASN A 1 147 ? 53.49958 -10.99638 13.10454 1.000 35.75096  ? 144 ASN A ND2  1 
ATOM   2225 H H    . ASN A 1 147 ? 51.68417 -12.72642 15.65319 1.000 32.70342  ? 144 ASN A H    1 
ATOM   2226 H HA   . ASN A 1 147 ? 52.55202 -10.52896 16.82608 1.000 32.18742  ? 144 ASN A HA   1 
ATOM   2227 H HB2  . ASN A 1 147 ? 51.37267 -10.95030 14.30773 1.000 33.54941  ? 144 ASN A HB2  1 
ATOM   2228 H HB3  . ASN A 1 147 ? 51.73580 -9.48378  14.80054 1.000 33.54941  ? 144 ASN A HB3  1 
ATOM   2229 H HD21 . ASN A 1 147 ? 54.28058 -11.11372 12.76414 1.000 42.92014  ? 144 ASN A HD21 1 
ATOM   2230 H HD22 . ASN A 1 147 ? 52.79743 -11.13478 12.62764 1.000 42.92014  ? 144 ASN A HD22 1 
ATOM   2231 N N    . ARG A 1 148 ? 50.64801 -9.10031  17.50114 1.000 23.92542  ? 145 ARG A N    1 
ATOM   2232 C CA   . ARG A 1 148 ? 49.50732 -8.49100  18.17300 1.000 25.02332  ? 145 ARG A CA   1 
ATOM   2233 C C    . ARG A 1 148 ? 48.42187 -8.13070  17.17179 1.000 23.24239  ? 145 ARG A C    1 
ATOM   2234 O O    . ARG A 1 148 ? 47.22373 -8.22269  17.47893 1.000 21.10029  ? 145 ARG A O    1 
ATOM   2235 C CB   . ARG A 1 148 ? 49.96591 -7.26049  18.94739 1.000 26.26911  ? 145 ARG A CB   1 
ATOM   2236 C CG   . ARG A 1 148 ? 50.91708 -7.59553  20.10768 1.000 27.74595  ? 145 ARG A CG   1 
ATOM   2237 C CD   . ARG A 1 148 ? 51.43467 -6.35373  20.80819 1.000 33.25573  ? 145 ARG A CD   1 
ATOM   2238 N NE   . ARG A 1 148 ? 50.35360 -5.54022  21.35709 1.000 33.15419  ? 145 ARG A NE   1 
ATOM   2239 C CZ   . ARG A 1 148 ? 49.74128 -5.78595  22.50937 1.000 33.39123  ? 145 ARG A CZ   1 
ATOM   2240 N NH1  . ARG A 1 148 ? 50.02458 -6.85891  23.22744 1.000 32.07262  ? 145 ARG A NH1  1 
ATOM   2241 N NH2  . ARG A 1 148 ? 48.81955 -4.93452  22.95307 1.000 33.94460  ? 145 ARG A NH2  1 
ATOM   2242 H H    . ARG A 1 148 ? 51.37315 -8.63886  17.53005 1.000 28.72949  ? 145 ARG A H    1 
ATOM   2243 H HA   . ARG A 1 148 ? 49.13092 -9.11984  18.80845 1.000 30.04696  ? 145 ARG A HA   1 
ATOM   2244 H HB2  . ARG A 1 148 ? 50.43266 -6.66400  18.34138 1.000 31.54192  ? 145 ARG A HB2  1 
ATOM   2245 H HB3  . ARG A 1 148 ? 49.18815 -6.81483  19.31804 1.000 31.54192  ? 145 ARG A HB3  1 
ATOM   2246 H HG2  . ARG A 1 148 ? 50.44407 -8.13449  20.76089 1.000 33.31413  ? 145 ARG A HG2  1 
ATOM   2247 H HG3  . ARG A 1 148 ? 51.67931 -8.08603  19.76227 1.000 33.31413  ? 145 ARG A HG3  1 
ATOM   2248 H HD2  . ARG A 1 148 ? 52.01471 -6.61867  21.53912 1.000 39.92585  ? 145 ARG A HD2  1 
ATOM   2249 H HD3  . ARG A 1 148 ? 51.92811 -5.81182  20.17277 1.000 39.92585  ? 145 ARG A HD3  1 
ATOM   2250 H HE   . ARG A 1 148 ? 50.09623 -4.85619  20.90381 1.000 39.80401  ? 145 ARG A HE   1 
ATOM   2251 H HH11 . ARG A 1 148 ? 50.61756 -7.41707  22.95099 1.000 38.50613  ? 145 ARG A HH11 1 
ATOM   2252 H HH12 . ARG A 1 148 ? 49.61592 -6.99884  23.97109 1.000 38.50613  ? 145 ARG A HH12 1 
ATOM   2253 H HH21 . ARG A 1 148 ? 48.62568 -4.23328  22.49452 1.000 40.75250  ? 145 ARG A HH21 1 
ATOM   2254 H HH22 . ARG A 1 148 ? 48.41784 -5.08561  23.69832 1.000 40.75250  ? 145 ARG A HH22 1 
ATOM   2255 N N    . VAL A 1 149 ? 48.82690 -7.71182  15.97161 1.000 22.15441  ? 146 VAL A N    1 
ATOM   2256 C CA   . VAL A 1 149 ? 47.92902 -7.52007  14.83793 1.000 21.59336  ? 146 VAL A CA   1 
ATOM   2257 C C    . VAL A 1 149 ? 48.54513 -8.23945  13.64802 1.000 22.86523  ? 146 VAL A C    1 
ATOM   2258 O O    . VAL A 1 149 ? 49.74987 -8.11464  13.40527 1.000 24.68886  ? 146 VAL A O    1 
ATOM   2259 C CB   . VAL A 1 149 ? 47.71039 -6.03294  14.50085 1.000 20.60038  ? 146 VAL A CB   1 
ATOM   2260 C CG1  . VAL A 1 149 ? 46.84422 -5.90117  13.25134 1.000 22.76236  ? 146 VAL A CG1  1 
ATOM   2261 C CG2  . VAL A 1 149 ? 47.09248 -5.30403  15.67674 1.000 22.99135  ? 146 VAL A CG2  1 
ATOM   2262 H H    . VAL A 1 149 ? 49.64601 -7.52664  15.78624 1.000 26.60428  ? 146 VAL A H    1 
ATOM   2263 H HA   . VAL A 1 149 ? 47.06393 -7.90746  15.04397 1.000 25.93102  ? 146 VAL A HA   1 
ATOM   2264 H HB   . VAL A 1 149 ? 48.56719 -5.61655  14.31807 1.000 24.73944  ? 146 VAL A HB   1 
ATOM   2265 H HG11 . VAL A 1 149 ? 46.56116 -4.97797  13.15922 1.000 27.33381  ? 146 VAL A HG11 1 
ATOM   2266 H HG12 . VAL A 1 149 ? 47.36462 -6.16643  12.47693 1.000 27.33381  ? 146 VAL A HG12 1 
ATOM   2267 H HG13 . VAL A 1 149 ? 46.06916 -6.47729  13.34217 1.000 27.33381  ? 146 VAL A HG13 1 
ATOM   2268 H HG21 . VAL A 1 149 ? 46.95477 -4.37472  15.43525 1.000 27.60860  ? 146 VAL A HG21 1 
ATOM   2269 H HG22 . VAL A 1 149 ? 46.24297 -5.71864  15.89428 1.000 27.60860  ? 146 VAL A HG22 1 
ATOM   2270 H HG23 . VAL A 1 149 ? 47.69335 -5.36296  16.43595 1.000 27.60860  ? 146 VAL A HG23 1 
ATOM   2271 N N    . GLU A 1 150 ? 47.73108 -8.99629  12.91652 1.000 21.84644  ? 147 GLU A N    1 
ATOM   2272 C CA   . GLU A 1 150 ? 48.18779 -9.73350  11.74807 1.000 22.62164  ? 147 GLU A CA   1 
ATOM   2273 C C    . GLU A 1 150 ? 47.26623 -9.40095  10.58428 1.000 23.65183  ? 147 GLU A C    1 
ATOM   2274 O O    . GLU A 1 150 ? 46.04028 -9.40499  10.73337 1.000 22.47168  ? 147 GLU A O    1 
ATOM   2275 C CB   . GLU A 1 150 ? 48.20935 -11.23934 11.99853 1.000 25.26549  ? 147 GLU A CB   1 
ATOM   2276 C CG   . GLU A 1 150 ? 48.92250 -12.01883 10.90409 1.000 28.20404  ? 147 GLU A CG   1 
ATOM   2277 C CD   . GLU A 1 150 ? 50.41303 -11.67113 10.80974 1.000 27.71414  ? 147 GLU A CD   1 
ATOM   2278 O OE1  . GLU A 1 150 ? 51.16487 -11.97163 11.75925 1.000 28.25641  ? 147 GLU A OE1  1 
ATOM   2279 O OE2  . GLU A 1 150 ? 50.81048 -11.06135 9.80340  1.000 33.03895  ? 147 GLU A OE2  1 
ATOM   2280 H H    . GLU A 1 150 ? 46.89355 -9.09877  13.08282 1.000 26.23471  ? 147 GLU A H    1 
ATOM   2281 H HA   . GLU A 1 150 ? 49.09177 -9.46320  11.52299 1.000 27.16495  ? 147 GLU A HA   1 
ATOM   2282 H HB2  . GLU A 1 150 ? 48.66844 -11.41184 12.83542 1.000 30.33757  ? 147 GLU A HB2  1 
ATOM   2283 H HB3  . GLU A 1 150 ? 47.29609 -11.56239 12.04840 1.000 30.33757  ? 147 GLU A HB3  1 
ATOM   2284 H HG2  . GLU A 1 150 ? 48.84624 -12.96780 11.08991 1.000 33.86383  ? 147 GLU A HG2  1 
ATOM   2285 H HG3  . GLU A 1 150 ? 48.51124 -11.81394 10.04982 1.000 33.86383  ? 147 GLU A HG3  1 
ATOM   2286 N N    . LYS A 1 151 ? 47.85862 -9.11364  9.43003  1.000 26.07494  ? 148 LYS A N    1 
ATOM   2287 C CA   . LYS A 1 151 ? 47.11345 -8.81757  8.21468  1.000 26.89709  ? 148 LYS A CA   1 
ATOM   2288 C C    . LYS A 1 151 ? 47.69593 -9.63658  7.07239  1.000 29.05207  ? 148 LYS A C    1 
ATOM   2289 O O    . LYS A 1 151 ? 48.87040 -9.48242  6.72572  1.000 30.30876  ? 148 LYS A O    1 
ATOM   2290 C CB   . LYS A 1 151 ? 47.16077 -7.32158  7.90193  1.000 27.46232  ? 148 LYS A CB   1 
ATOM   2291 C CG   . LYS A 1 151 ? 46.20540 -6.90406  6.77143  1.000 33.77610  ? 148 LYS A CG   1 
ATOM   2292 C CD   . LYS A 1 151 ? 46.31709 -5.40890  6.48311  1.000 38.47899  ? 148 LYS A CD   1 
ATOM   2293 C CE   . LYS A 1 151 ? 45.40547 -4.99851  5.32280  1.000 48.90591  ? 148 LYS A CE   1 
ATOM   2294 N NZ   . LYS A 1 151 ? 45.72896 -5.73079  4.05502  1.000 59.27806  ? 148 LYS A NZ   1 
ATOM   2295 H H    A LYS A 1 151 ? 48.71164 -9.08370  9.32485  0.340 31.30891  ? 148 LYS A H    1 
ATOM   2296 H H    B LYS A 1 151 ? 48.71164 -9.08370  9.32485  0.660 31.30891  ? 148 LYS A H    1 
ATOM   2297 H HA   . LYS A 1 151 ? 46.18522 -9.07735  8.32334  1.000 32.29550  ? 148 LYS A HA   1 
ATOM   2298 H HB2  . LYS A 1 151 ? 46.91330 -6.82696  8.69881  1.000 32.97376  ? 148 LYS A HB2  1 
ATOM   2299 H HB3  . LYS A 1 151 ? 48.06228 -7.08632  7.63204  1.000 32.97376  ? 148 LYS A HB3  1 
ATOM   2300 H HG2  . LYS A 1 151 ? 46.43017 -7.39004  5.96260  1.000 40.55031  ? 148 LYS A HG2  1 
ATOM   2301 H HG3  . LYS A 1 151 ? 45.29165 -7.09872  7.03233  1.000 40.55031  ? 148 LYS A HG3  1 
ATOM   2302 H HD2  . LYS A 1 151 ? 46.05385 -4.90810  7.27102  1.000 46.19377  ? 148 LYS A HD2  1 
ATOM   2303 H HD3  . LYS A 1 151 ? 47.23230 -5.19418  6.24397  1.000 46.19377  ? 148 LYS A HD3  1 
ATOM   2304 H HE2  . LYS A 1 151 ? 44.48493 -5.19464  5.55739  1.000 58.70607  ? 148 LYS A HE2  1 
ATOM   2305 H HE3  . LYS A 1 151 ? 45.51042 -4.04855  5.15706  1.000 58.70607  ? 148 LYS A HE3  1 
ATOM   2306 H HZ1  . LYS A 1 151 ? 45.22736 -5.42120  3.38820  1.000 71.15266  ? 148 LYS A HZ1  1 
ATOM   2307 H HZ2  . LYS A 1 151 ? 46.58701 -5.61670  3.84805  1.000 71.15266  ? 148 LYS A HZ2  1 
ATOM   2308 H HZ3  . LYS A 1 151 ? 45.56953 -6.60048  4.15668  1.000 71.15266  ? 148 LYS A HZ3  1 
ATOM   2309 N N    . ASP A 1 152 ? 46.88768 -10.52867 6.51505  1.000 28.77080  ? 149 ASP A N    1 
ATOM   2310 C CA   . ASP A 1 152 ? 47.29603 -11.35950 5.38675  1.000 31.80841  ? 149 ASP A CA   1 
ATOM   2311 C C    . ASP A 1 152 ? 46.23564 -11.20096 4.31013  1.000 35.59253  ? 149 ASP A C    1 
ATOM   2312 O O    . ASP A 1 152 ? 45.12893 -11.73271 4.44443  1.000 29.82862  ? 149 ASP A O    1 
ATOM   2313 C CB   . ASP A 1 152 ? 47.45918 -12.82528 5.79583  1.000 30.60992  ? 149 ASP A CB   1 
ATOM   2314 C CG   . ASP A 1 152 ? 48.17214 -13.65451 4.73009  1.000 34.37372  ? 149 ASP A CG   1 
ATOM   2315 O OD1  . ASP A 1 152 ? 48.70850 -13.06996 3.76784  1.000 36.07532  ? 149 ASP A OD1  1 
ATOM   2316 O OD2  . ASP A 1 152 ? 48.19093 -14.89033 4.84656  1.000 31.62259  ? 149 ASP A OD2  1 
ATOM   2317 H H    . ASP A 1 152 ? 46.08173 -10.67484 6.77714  1.000 34.54394  ? 149 ASP A H    1 
ATOM   2318 H HA   . ASP A 1 152 ? 48.15025 -11.05686 5.04090  1.000 38.18908  ? 149 ASP A HA   1 
ATOM   2319 H HB2  . ASP A 1 152 ? 47.98193 -12.87034 6.61167  1.000 36.75089  ? 149 ASP A HB2  1 
ATOM   2320 H HB3  . ASP A 1 152 ? 46.58215 -13.21306 5.94192  1.000 36.75089  ? 149 ASP A HB3  1 
ATOM   2321 N N    . GLY A 1 153 ? 46.55051 -10.42805 3.27667  1.000 42.59049  ? 150 GLY A N    1 
ATOM   2322 C CA   . GLY A 1 153 ? 45.57030 -10.19406 2.22898  1.000 55.31833  ? 150 GLY A CA   1 
ATOM   2323 C C    . GLY A 1 153 ? 44.41874 -9.36315  2.78524  1.000 34.08932  ? 150 GLY A C    1 
ATOM   2324 O O    . GLY A 1 153 ? 44.58998 -8.24743  3.31168  1.000 36.85404  ? 150 GLY A O    1 
ATOM   2325 H H    . GLY A 1 153 ? 47.30763 -10.03670 3.16177  1.000 51.12757  ? 150 GLY A H    1 
ATOM   2326 H HA2  . GLY A 1 153 ? 45.97968 -9.71537  1.49130  1.000 66.40098  ? 150 GLY A HA2  1 
ATOM   2327 H HA3  . GLY A 1 153 ? 45.22337 -11.03929 1.90322  1.000 66.40098  ? 150 GLY A HA3  1 
ATOM   2328 N N    . LEU A 1 154 ? 43.21448 -9.91388  2.68590  1.000 36.20563  ? 151 LEU A N    1 
ATOM   2329 C CA   . LEU A 1 154 ? 42.00908 -9.23262  3.13627  1.000 37.92443  ? 151 LEU A CA   1 
ATOM   2330 C C    . LEU A 1 154 ? 41.55897 -9.68295  4.52358  1.000 33.19510  ? 151 LEU A C    1 
ATOM   2331 O O    . LEU A 1 154 ? 40.45251 -9.33039  4.94752  1.000 28.76924  ? 151 LEU A O    1 
ATOM   2332 C CB   . LEU A 1 154 ? 40.88037 -9.44206  2.12183  1.000 48.62169  ? 151 LEU A CB   1 
ATOM   2333 C CG   . LEU A 1 154 ? 40.31083 -10.85742 1.97984  1.000 60.96500  ? 151 LEU A CG   1 
ATOM   2334 C CD1  . LEU A 1 154 ? 39.16257 -11.08487 2.97113  1.000 66.87615  ? 151 LEU A CD1  1 
ATOM   2335 C CD2  . LEU A 1 154 ? 39.84264 -11.12187 0.55119  1.000 51.13892  ? 151 LEU A CD2  1 
ATOM   2336 H H    . LEU A 1 154 ? 43.06859 -10.69435 2.35548  1.000 43.46573  ? 151 LEU A H    1 
ATOM   2337 H HA   . LEU A 1 154 ? 42.19362 -8.28161  3.18560  1.000 45.52830  ? 151 LEU A HA   1 
ATOM   2338 H HB2  . LEU A 1 154 ? 40.14220 -8.86661  2.37651  1.000 58.36501  ? 151 LEU A HB2  1 
ATOM   2339 H HB3  . LEU A 1 154 ? 41.21520 -9.18522  1.24843  1.000 58.36501  ? 151 LEU A HB3  1 
ATOM   2340 H HG   . LEU A 1 154 ? 41.01592 -11.49177 2.18318  1.000 73.17698  ? 151 LEU A HG   1 
ATOM   2341 H HD11 . LEU A 1 154 ? 38.56265 -11.75654 2.61077  1.000 80.27037  ? 151 LEU A HD11 1 
ATOM   2342 H HD12 . LEU A 1 154 ? 39.53011 -11.38864 3.81584  1.000 80.27037  ? 151 LEU A HD12 1 
ATOM   2343 H HD13 . LEU A 1 154 ? 38.68573 -10.24990 3.09904  1.000 80.27037  ? 151 LEU A HD13 1 
ATOM   2344 H HD21 . LEU A 1 154 ? 39.48458 -12.02178 0.49768  1.000 61.38569  ? 151 LEU A HD21 1 
ATOM   2345 H HD22 . LEU A 1 154 ? 39.15501 -10.47799 0.31991  1.000 61.38569  ? 151 LEU A HD22 1 
ATOM   2346 H HD23 . LEU A 1 154 ? 40.59774 -11.02998 -0.05071 1.000 61.38569  ? 151 LEU A HD23 1 
ATOM   2347 N N    . ILE A 1 155 ? 42.39015 -10.43732 5.24122  1.000 28.94388  ? 152 ILE A N    1 
ATOM   2348 C CA   . ILE A 1 155 ? 42.04939 -10.96883 6.55618  1.000 28.29753  ? 152 ILE A CA   1 
ATOM   2349 C C    . ILE A 1 155 ? 42.93149 -10.27694 7.58765  1.000 24.44237  ? 152 ILE A C    1 
ATOM   2350 O O    . ILE A 1 155 ? 44.16261 -10.41215 7.57026  1.000 22.57543  ? 152 ILE A O    1 
ATOM   2351 C CB   . ILE A 1 155 ? 42.22346 -12.49320 6.63000  1.000 29.98345  ? 152 ILE A CB   1 
ATOM   2352 C CG1  . ILE A 1 155 ? 41.36812 -13.19583 5.57218  1.000 33.00234  ? 152 ILE A CG1  1 
ATOM   2353 C CG2  . ILE A 1 155 ? 41.88471 -12.98196 8.03817  1.000 27.36176  ? 152 ILE A CG2  1 
ATOM   2354 C CD1  . ILE A 1 155 ? 39.89602 -13.13020 5.83638  1.000 36.00074  ? 152 ILE A CD1  1 
ATOM   2355 H H    . ILE A 1 155 ? 43.17820 -10.65963 4.97824  1.000 34.75164  ? 152 ILE A H    1 
ATOM   2356 H HA   . ILE A 1 155 ? 41.12156 -10.75873 6.74564  1.000 33.97601  ? 152 ILE A HA   1 
ATOM   2357 H HB   . ILE A 1 155 ? 43.14920 -12.71174 6.43988  1.000 35.99912  ? 152 ILE A HB   1 
ATOM   2358 H HG12 . ILE A 1 155 ? 41.53227 -12.77822 4.71220  1.000 39.62178  ? 152 ILE A HG12 1 
ATOM   2359 H HG13 . ILE A 1 155 ? 41.62048 -14.13187 5.54001  1.000 39.62178  ? 152 ILE A HG13 1 
ATOM   2360 H HG21 . ILE A 1 155 ? 41.74507 -13.94156 8.01432  1.000 32.85310  ? 152 ILE A HG21 1 
ATOM   2361 H HG22 . ILE A 1 155 ? 42.62173 -12.76962 8.63198  1.000 32.85310  ? 152 ILE A HG22 1 
ATOM   2362 H HG23 . ILE A 1 155 ? 41.07738 -12.53764 8.34099  1.000 32.85310  ? 152 ILE A HG23 1 
ATOM   2363 H HD11 . ILE A 1 155 ? 39.42321 -13.53325 5.09146  1.000 43.21987  ? 152 ILE A HD11 1 
ATOM   2364 H HD12 . ILE A 1 155 ? 39.69994 -13.61452 6.65362  1.000 43.21987  ? 152 ILE A HD12 1 
ATOM   2365 H HD13 . ILE A 1 155 ? 39.63331 -12.20128 5.93125  1.000 43.21987  ? 152 ILE A HD13 1 
ATOM   2366 N N    . LEU A 1 156 ? 42.30080 -9.55600  8.50343  1.000 22.43411  ? 153 LEU A N    1 
ATOM   2367 C CA   . LEU A 1 156 ? 42.99843 -8.81954  9.55259  1.000 22.76921  ? 153 LEU A CA   1 
ATOM   2368 C C    . LEU A 1 156 ? 42.53973 -9.37232  10.89347 1.000 21.69015  ? 153 LEU A C    1 
ATOM   2369 O O    . LEU A 1 156 ? 41.33923 -9.36501  11.18838 1.000 22.09735  ? 153 LEU A O    1 
ATOM   2370 C CB   . LEU A 1 156 ? 42.71100 -7.32144  9.44111  1.000 25.14500  ? 153 LEU A CB   1 
ATOM   2371 C CG   . LEU A 1 156 ? 43.54675 -6.33096  10.24798 1.000 27.14727  ? 153 LEU A CG   1 
ATOM   2372 C CD1  . LEU A 1 156 ? 43.47360 -4.96502  9.57618  1.000 39.77030  ? 153 LEU A CD1  1 
ATOM   2373 C CD2  . LEU A 1 156 ? 43.08246 -6.24918  11.66294 1.000 32.80946  ? 153 LEU A CD2  1 
ATOM   2374 H H    . LEU A 1 156 ? 41.44545 -9.47466  8.54032  1.000 26.93991  ? 153 LEU A H    1 
ATOM   2375 H HA   . LEU A 1 156 ? 43.95743 -8.94589  9.48010  1.000 27.34204  ? 153 LEU A HA   1 
ATOM   2376 H HB2  . LEU A 1 156 ? 42.82266 -7.07520  8.50955  1.000 30.19298  ? 153 LEU A HB2  1 
ATOM   2377 H HB3  . LEU A 1 156 ? 41.78997 -7.18381  9.71254  1.000 30.19298  ? 153 LEU A HB3  1 
ATOM   2378 H HG   . LEU A 1 156 ? 44.46914 -6.62996  10.27427 1.000 32.59570  ? 153 LEU A HG   1 
ATOM   2379 H HD11 . LEU A 1 156 ? 43.94603 -4.31827  10.12338 1.000 47.74334  ? 153 LEU A HD11 1 
ATOM   2380 H HD12 . LEU A 1 156 ? 43.88631 -5.02143  8.70017  1.000 47.74334  ? 153 LEU A HD12 1 
ATOM   2381 H HD13 . LEU A 1 156 ? 42.54300 -4.70621  9.48736  1.000 47.74334  ? 153 LEU A HD13 1 
ATOM   2382 H HD21 . LEU A 1 156 ? 43.55088 -5.52552  12.10769 1.000 39.39034  ? 153 LEU A HD21 1 
ATOM   2383 H HD22 . LEU A 1 156 ? 42.12733 -6.08027  11.67264 1.000 39.39034  ? 153 LEU A HD22 1 
ATOM   2384 H HD23 . LEU A 1 156 ? 43.27424 -7.08980  12.10733 1.000 39.39034  ? 153 LEU A HD23 1 
ATOM   2385 N N    . THR A 1 157 ? 43.48644 -9.83659  11.71105 1.000 20.79207  ? 154 THR A N    1 
ATOM   2386 C CA   . THR A 1 157 ? 43.15031 -10.43607 12.99201 1.000 19.64574  ? 154 THR A CA   1 
ATOM   2387 C C    . THR A 1 157 ? 44.00307 -9.82784  14.09712 1.000 20.65711  ? 154 THR A C    1 
ATOM   2388 O O    . THR A 1 157 ? 45.05337 -9.22498  13.85077 1.000 18.78752  ? 154 THR A O    1 
ATOM   2389 C CB   . THR A 1 157 ? 43.33856 -11.97090 12.96613 1.000 20.77873  ? 154 THR A CB   1 
ATOM   2390 O OG1  . THR A 1 157 ? 44.65653 -12.28978 12.49480 1.000 19.47871  ? 154 THR A OG1  1 
ATOM   2391 C CG2  . THR A 1 157 ? 42.30313 -12.62374 12.08342 1.000 20.92056  ? 154 THR A CG2  1 
ATOM   2392 H H    . THR A 1 157 ? 44.32912 -9.81307  11.54093 1.000 24.96946  ? 154 THR A H    1 
ATOM   2393 H HA   . THR A 1 157 ? 42.22171 -10.24300 13.19531 1.000 23.59387  ? 154 THR A HA   1 
ATOM   2394 H HB   . THR A 1 157 ? 43.22904 -12.32428 13.86280 1.000 24.95346  ? 154 THR A HB   1 
ATOM   2395 H HG1  . THR A 1 157 ? 44.74326 -12.04428 11.69617 1.000 23.39343  ? 154 THR A HG1  1 
ATOM   2396 H HG21 . THR A 1 157 ? 42.44048 -13.58379 12.06514 1.000 25.12366  ? 154 THR A HG21 1 
ATOM   2397 H HG22 . THR A 1 157 ? 41.41355 -12.43942 12.42339 1.000 25.12366  ? 154 THR A HG22 1 
ATOM   2398 H HG23 . THR A 1 157 ? 42.37248 -12.27855 11.17957 1.000 25.12366  ? 154 THR A HG23 1 
ATOM   2399 N N    . SER A 1 158 ? 43.53392 -10.01014 15.32901 1.000 18.19941  ? 155 SER A N    1 
ATOM   2400 C CA   . SER A 1 158 ? 44.19156 -9.46081  16.50419 1.000 18.94628  ? 155 SER A CA   1 
ATOM   2401 C C    . SER A 1 158 ? 43.86024 -10.35366 17.69886 1.000 18.50598  ? 155 SER A C    1 
ATOM   2402 O O    . SER A 1 158 ? 42.96682 -11.20607 17.64025 1.000 19.31555  ? 155 SER A O    1 
ATOM   2403 C CB   . SER A 1 158 ? 43.77148 -8.00428  16.72872 1.000 19.22615  ? 155 SER A CB   1 
ATOM   2404 O OG   . SER A 1 158 ? 44.70131 -7.33225  17.55999 1.000 20.25510  ? 155 SER A OG   1 
ATOM   2405 H H    . SER A 1 158 ? 42.82229 -10.45740 15.51103 1.000 21.85827  ? 155 SER A H    1 
ATOM   2406 H HA   . SER A 1 158 ? 45.15504 -9.47296  16.39264 1.000 22.75452  ? 155 SER A HA   1 
ATOM   2407 H HB2  . SER A 1 158 ? 43.73028 -7.55209  15.87155 1.000 23.09036  ? 155 SER A HB2  1 
ATOM   2408 H HB3  . SER A 1 158 ? 42.89979 -7.98930  17.15395 1.000 23.09036  ? 155 SER A HB3  1 
ATOM   2409 H HG   . SER A 1 158 ? 44.73577 -7.70464  18.31215 1.000 24.32510  ? 155 SER A HG   1 
ATOM   2410 N N    . ARG A 1 159 ? 44.57750 -10.14017 18.80217 1.000 18.67767  ? 156 ARG A N    1 
ATOM   2411 C CA   . ARG A 1 159 ? 44.67510 -11.16892 19.83402 1.000 19.65617  ? 156 ARG A CA   1 
ATOM   2412 C C    . ARG A 1 159 ? 43.71754 -11.00746 21.01141 1.000 21.83313  ? 156 ARG A C    1 
ATOM   2413 O O    . ARG A 1 159 ? 43.22170 -12.01129 21.53260 1.000 21.22617  ? 156 ARG A O    1 
ATOM   2414 C CB   . ARG A 1 159 ? 46.10920 -11.22977 20.35825 1.000 21.62670  ? 156 ARG A CB   1 
ATOM   2415 C CG   . ARG A 1 159 ? 47.15096 -11.44415 19.27062 1.000 22.46407  ? 156 ARG A CG   1 
ATOM   2416 C CD   . ARG A 1 159 ? 48.35178 -12.20188 19.83280 1.000 22.34228  ? 156 ARG A CD   1 
ATOM   2417 N NE   . ARG A 1 159 ? 48.04439 -13.61728 19.99003 1.000 23.93694  ? 156 ARG A NE   1 
ATOM   2418 C CZ   . ARG A 1 159 ? 48.84560 -14.49638 20.56702 1.000 26.50424  ? 156 ARG A CZ   1 
ATOM   2419 N NH1  . ARG A 1 159 ? 49.99286 -14.12846 21.11318 1.000 30.84298  ? 156 ARG A NH1  1 
ATOM   2420 N NH2  . ARG A 1 159 ? 48.48617 -15.77477 20.59402 1.000 26.87371  ? 156 ARG A NH2  1 
ATOM   2421 H H    . ARG A 1 159 ? 45.01026 -9.41668  18.97214 1.000 22.43218  ? 156 ARG A H    1 
ATOM   2422 H HA   . ARG A 1 159 ? 44.44691 -12.01660 19.42139 1.000 23.60639  ? 156 ARG A HA   1 
ATOM   2423 H HB2  . ARG A 1 159 ? 46.31408 -10.39280 20.80366 1.000 25.97103  ? 156 ARG A HB2  1 
ATOM   2424 H HB3  . ARG A 1 159 ? 46.18070 -11.96582 20.98596 1.000 25.97103  ? 156 ARG A HB3  1 
ATOM   2425 H HG2  . ARG A 1 159 ? 46.76608 -11.96463 18.54822 1.000 26.97586  ? 156 ARG A HG2  1 
ATOM   2426 H HG3  . ARG A 1 159 ? 47.45459 -10.58585 18.93593 1.000 26.97586  ? 156 ARG A HG3  1 
ATOM   2427 H HD2  . ARG A 1 159 ? 49.10247 -12.11563 19.22458 1.000 26.82972  ? 156 ARG A HD2  1 
ATOM   2428 H HD3  . ARG A 1 159 ? 48.58537 -11.83926 20.70162 1.000 26.82972  ? 156 ARG A HD3  1 
ATOM   2429 H HE   . ARG A 1 159 ? 47.29082 -13.90000 19.68703 1.000 28.74331  ? 156 ARG A HE   1 
ATOM   2430 H HH11 . ARG A 1 159 ? 50.23116 -13.30229 21.09755 1.000 37.03056  ? 156 ARG A HH11 1 
ATOM   2431 H HH12 . ARG A 1 159 ? 50.50043 -14.71545 21.48388 1.000 37.03056  ? 156 ARG A HH12 1 
ATOM   2432 H HH21 . ARG A 1 159 ? 47.74194 -16.01978 20.23947 1.000 32.26743  ? 156 ARG A HH21 1 
ATOM   2433 H HH22 . ARG A 1 159 ? 48.99766 -16.35749 20.96604 1.000 32.26743  ? 156 ARG A HH22 1 
ATOM   2434 N N    . GLY A 1 160 ? 43.45716 -9.79997  21.48758 1.000 22.36229  ? 157 GLY A N    1 
ATOM   2435 C CA   . GLY A 1 160 ? 42.66126 -9.67128  22.68776 1.000 19.68009  ? 157 GLY A CA   1 
ATOM   2436 C C    . GLY A 1 160 ? 42.23014 -8.26392  23.03309 1.000 20.38965  ? 157 GLY A C    1 
ATOM   2437 O O    . GLY A 1 160 ? 42.45085 -7.31349  22.28012 1.000 20.28321  ? 157 GLY A O    1 
ATOM   2438 H H    . GLY A 1 160 ? 43.72505 -9.06051  21.13971 1.000 26.85373  ? 157 GLY A H    1 
ATOM   2439 H HA2  . GLY A 1 160 ? 41.85861 -10.20621 22.58528 1.000 23.63509  ? 157 GLY A HA2  1 
ATOM   2440 H HA3  . GLY A 1 160 ? 43.17441 -10.01212 23.43703 1.000 23.63509  ? 157 GLY A HA3  1 
ATOM   2441 N N    . PRO A 1 161 ? 41.56234 -8.11698  24.18232 1.000 20.66320  ? 158 PRO A N    1 
ATOM   2442 C CA   . PRO A 1 161 ? 41.07484 -6.78310  24.57467 1.000 22.50088  ? 158 PRO A CA   1 
ATOM   2443 C C    . PRO A 1 161 ? 42.15941 -5.73088  24.58065 1.000 21.45162  ? 158 PRO A C    1 
ATOM   2444 O O    . PRO A 1 161 ? 41.92222 -4.60545  24.12254 1.000 21.96874  ? 158 PRO A O    1 
ATOM   2445 C CB   . PRO A 1 161 ? 40.50435 -7.01682  25.97845 1.000 23.59300  ? 158 PRO A CB   1 
ATOM   2446 C CG   . PRO A 1 161 ? 40.15295 -8.47309  26.01154 1.000 23.32918  ? 158 PRO A CG   1 
ATOM   2447 C CD   . PRO A 1 161 ? 41.19835 -9.16094  25.16124 1.000 21.05748  ? 158 PRO A CD   1 
ATOM   2448 H HA   . PRO A 1 161 ? 40.35868 -6.50843  23.98089 1.000 27.02004  ? 158 PRO A HA   1 
ATOM   2449 H HB2  . PRO A 1 161 ? 41.17428 -6.80538  26.64732 1.000 28.33058  ? 158 PRO A HB2  1 
ATOM   2450 H HB3  . PRO A 1 161 ? 39.71714 -6.46595  26.11165 1.000 28.33058  ? 158 PRO A HB3  1 
ATOM   2451 H HG2  . PRO A 1 161 ? 40.18340 -8.79774  26.92509 1.000 28.01400  ? 158 PRO A HG2  1 
ATOM   2452 H HG3  . PRO A 1 161 ? 39.26604 -8.60554  25.64177 1.000 28.01400  ? 158 PRO A HG3  1 
ATOM   2453 H HD2  . PRO A 1 161 ? 41.96585 -9.41852  25.69556 1.000 25.28796  ? 158 PRO A HD2  1 
ATOM   2454 H HD3  . PRO A 1 161 ? 40.82721 -9.93921  24.71689 1.000 25.28796  ? 158 PRO A HD3  1 
ATOM   2455 N N    . GLY A 1 162 ? 43.35539 -6.08191  25.05848 1.000 22.01172  ? 159 GLY A N    1 
ATOM   2456 C CA   . GLY A 1 162 ? 44.47497 -5.16433  25.11296 1.000 23.90005  ? 159 GLY A CA   1 
ATOM   2457 C C    . GLY A 1 162 ? 45.09725 -4.83457  23.77654 1.000 22.98013  ? 159 GLY A C    1 
ATOM   2458 O O    . GLY A 1 162 ? 45.98150 -3.97169  23.73338 1.000 22.47657  ? 159 GLY A O    1 
ATOM   2459 H H    . GLY A 1 162 ? 43.54080 -6.86483  25.36220 1.000 26.43305  ? 159 GLY A H    1 
ATOM   2460 H HA2  . GLY A 1 162 ? 44.17495 -4.33258  25.51178 1.000 28.69904  ? 159 GLY A HA2  1 
ATOM   2461 H HA3  . GLY A 1 162 ? 45.16620 -5.55161  25.67254 1.000 28.69904  ? 159 GLY A HA3  1 
ATOM   2462 N N    . THR A 1 163 ? 44.68514 -5.50541  22.69997 1.000 21.75596  ? 160 THR A N    1 
ATOM   2463 C CA   . THR A 1 163 ? 45.14150 -5.16508  21.35941 1.000 20.90687  ? 160 THR A CA   1 
ATOM   2464 C C    . THR A 1 163 ? 44.08110 -4.41630  20.56500 1.000 21.09878  ? 160 THR A C    1 
ATOM   2465 O O    . THR A 1 163 ? 44.27614 -4.16930  19.36992 1.000 19.33579  ? 160 THR A O    1 
ATOM   2466 C CB   . THR A 1 163 ? 45.58295 -6.41979  20.58591 1.000 21.36277  ? 160 THR A CB   1 
ATOM   2467 O OG1  . THR A 1 163 ? 44.47405 -7.28681  20.32552 1.000 18.11340  ? 160 THR A OG1  1 
ATOM   2468 C CG2  . THR A 1 163 ? 46.63000 -7.19601  21.37882 1.000 24.28484  ? 160 THR A CG2  1 
ATOM   2469 H H    . THR A 1 163 ? 44.13628 -6.16702  22.72476 1.000 26.12614  ? 160 THR A H    1 
ATOM   2470 H HA   . THR A 1 163 ? 45.92189 -4.59545  21.44547 1.000 25.10723  ? 160 THR A HA   1 
ATOM   2471 H HB   . THR A 1 163 ? 45.96261 -6.13402  19.74028 1.000 25.65431  ? 160 THR A HB   1 
ATOM   2472 H HG1  . THR A 1 163 ? 43.92687 -6.90750  19.81336 1.000 21.75506  ? 160 THR A HG1  1 
ATOM   2473 H HG21 . THR A 1 163 ? 46.91581 -7.97528  20.87687 1.000 29.16079  ? 160 THR A HG21 1 
ATOM   2474 H HG22 . THR A 1 163 ? 47.40054 -6.63259  21.55120 1.000 29.16079  ? 160 THR A HG22 1 
ATOM   2475 H HG23 . THR A 1 163 ? 46.25671 -7.48655  22.22566 1.000 29.16079  ? 160 THR A HG23 1 
ATOM   2476 N N    . SER A 1 164 ? 42.98345 -4.01494  21.21322 1.000 18.87224  ? 161 SER A N    1 
ATOM   2477 C CA   . SER A 1 164 ? 41.83566 -3.48462  20.48666 1.000 18.57548  ? 161 SER A CA   1 
ATOM   2478 C C    . SER A 1 164 ? 42.15666 -2.15209  19.82737 1.000 18.74813  ? 161 SER A C    1 
ATOM   2479 O O    . SER A 1 164 ? 41.66066 -1.86457  18.73008 1.000 20.25350  ? 161 SER A O    1 
ATOM   2480 C CB   . SER A 1 164 ? 40.63904 -3.33486  21.42915 1.000 20.53524  ? 161 SER A CB   1 
ATOM   2481 O OG   . SER A 1 164 ? 40.12026 -4.60253  21.77863 1.000 20.32450  ? 161 SER A OG   1 
ATOM   2482 H H    . SER A 1 164 ? 42.88144 -4.04014  22.06677 1.000 22.66567  ? 161 SER A H    1 
ATOM   2483 H HA   . SER A 1 164 ? 41.59767 -4.11509  19.78898 1.000 22.30955  ? 161 SER A HA   1 
ATOM   2484 H HB2  . SER A 1 164 ? 40.92560 -2.87675  22.23471 1.000 24.66127  ? 161 SER A HB2  1 
ATOM   2485 H HB3  . SER A 1 164 ? 39.94720 -2.82124  20.98368 1.000 24.66127  ? 161 SER A HB3  1 
ATOM   2486 H HG   . SER A 1 164 ? 39.45209 -4.51139  22.27947 1.000 24.40838  ? 161 SER A HG   1 
ATOM   2487 N N    . PHE A 1 165 ? 42.97331 -1.31701  20.47605 1.000 18.88753  ? 162 PHE A N    1 
ATOM   2488 C CA   . PHE A 1 165 ? 43.33619 -0.04251  19.85922 1.000 20.53494  ? 162 PHE A CA   1 
ATOM   2489 C C    . PHE A 1 165 ? 44.17931 -0.26288  18.60886 1.000 20.51006  ? 162 PHE A C    1 
ATOM   2490 O O    . PHE A 1 165 ? 43.93494 0.34815   17.56557 1.000 20.92035  ? 162 PHE A O    1 
ATOM   2491 C CB   . PHE A 1 165 ? 44.08940 0.83964   20.85725 1.000 22.50532  ? 162 PHE A CB   1 
ATOM   2492 C CG   . PHE A 1 165 ? 43.20682 1.49186   21.87312 1.000 23.44557  ? 162 PHE A CG   1 
ATOM   2493 C CD1  . PHE A 1 165 ? 42.42262 2.57783   21.52874 1.000 22.78784  ? 162 PHE A CD1  1 
ATOM   2494 C CD2  . PHE A 1 165 ? 43.17569 1.03655   23.17480 1.000 23.79523  ? 162 PHE A CD2  1 
ATOM   2495 C CE1  . PHE A 1 165 ? 41.60325 3.20157   22.48416 1.000 23.64737  ? 162 PHE A CE1  1 
ATOM   2496 C CE2  . PHE A 1 165 ? 42.35289 1.64450   24.12689 1.000 26.62127  ? 162 PHE A CE2  1 
ATOM   2497 C CZ   . PHE A 1 165 ? 41.57278 2.72462   23.77577 1.000 25.63695  ? 162 PHE A CZ   1 
ATOM   2498 H H    . PHE A 1 165 ? 43.31943 -1.46122  21.25001 1.000 22.68402  ? 162 PHE A H    1 
ATOM   2499 H HA   . PHE A 1 165 ? 42.52160 0.41928   19.60604 1.000 24.66091  ? 162 PHE A HA   1 
ATOM   2500 H HB2  . PHE A 1 165 ? 44.73343 0.29208   21.33296 1.000 27.02537  ? 162 PHE A HB2  1 
ATOM   2501 H HB3  . PHE A 1 165 ? 44.54727 1.54166   20.36895 1.000 27.02537  ? 162 PHE A HB3  1 
ATOM   2502 H HD1  . PHE A 1 165 ? 42.43792 2.89832   20.65584 1.000 27.36440  ? 162 PHE A HD1  1 
ATOM   2503 H HD2  . PHE A 1 165 ? 43.70901 0.31587   23.42198 1.000 28.57325  ? 162 PHE A HD2  1 
ATOM   2504 H HE1  . PHE A 1 165 ? 41.08292 3.93441   22.24521 1.000 28.39582  ? 162 PHE A HE1  1 
ATOM   2505 H HE2  . PHE A 1 165 ? 42.33186 1.31978   24.99810 1.000 31.96451  ? 162 PHE A HE2  1 
ATOM   2506 H HZ   . PHE A 1 165 ? 41.02679 3.13074   24.40969 1.000 30.78332  ? 162 PHE A HZ   1 
ATOM   2507 N N    . GLU A 1 166 ? 45.19308 -1.12311  18.70323 1.000 20.15719  ? 163 GLU A N    1 
ATOM   2508 C CA   . GLU A 1 166 ? 46.03179 -1.41136  17.54761 1.000 22.97762  ? 163 GLU A CA   1 
ATOM   2509 C C    . GLU A 1 166 ? 45.21254 -2.04578  16.43665 1.000 20.83019  ? 163 GLU A C    1 
ATOM   2510 O O    . GLU A 1 166 ? 45.39071 -1.71395  15.26186 1.000 20.32288  ? 163 GLU A O    1 
ATOM   2511 C CB   . GLU A 1 166 ? 47.18848 -2.32243  17.96050 1.000 25.11762  ? 163 GLU A CB   1 
ATOM   2512 C CG   . GLU A 1 166 ? 48.06606 -1.73279  19.04519 1.000 29.84620  ? 163 GLU A CG   1 
ATOM   2513 C CD   . GLU A 1 166 ? 48.64968 -2.78161  19.96500 1.000 38.91362  ? 163 GLU A CD   1 
ATOM   2514 O OE1  . GLU A 1 166 ? 49.59973 -3.47557  19.54894 1.000 35.97181  ? 163 GLU A OE1  1 
ATOM   2515 O OE2  . GLU A 1 166 ? 48.14182 -2.92302  21.09443 1.000 44.04308  ? 163 GLU A OE2  1 
ATOM   2516 H H    . GLU A 1 166 ? 45.41268 -1.54778  19.41809 1.000 24.20760  ? 163 GLU A H    1 
ATOM   2517 H HA   . GLU A 1 166 ? 46.41148 -0.58535  17.20930 1.000 27.59212  ? 163 GLU A HA   1 
ATOM   2518 H HB2  . GLU A 1 166 ? 46.82486 -3.15759  18.29395 1.000 30.16013  ? 163 GLU A HB2  1 
ATOM   2519 H HB3  . GLU A 1 166 ? 47.74671 -2.48975  17.18508 1.000 30.16013  ? 163 GLU A HB3  1 
ATOM   2520 H HG2  . GLU A 1 166 ? 48.80172 -1.25516  18.63097 1.000 35.83443  ? 163 GLU A HG2  1 
ATOM   2521 H HG3  . GLU A 1 166 ? 47.53638 -1.12398  19.58340 1.000 35.83443  ? 163 GLU A HG3  1 
ATOM   2522 N N    . PHE A 1 167 ? 44.29121 -2.93949  16.80224 1.000 18.14728  ? 164 PHE A N    1 
ATOM   2523 C CA   . PHE A 1 167 ? 43.36799 -3.55078  15.85111 1.000 19.49534  ? 164 PHE A CA   1 
ATOM   2524 C C    . PHE A 1 167 ? 42.55277 -2.49120  15.12705 1.000 20.94579  ? 164 PHE A C    1 
ATOM   2525 O O    . PHE A 1 167 ? 42.48554 -2.48106  13.89209 1.000 19.88969  ? 164 PHE A O    1 
ATOM   2526 C CB   . PHE A 1 167 ? 42.47623 -4.52013  16.63093 1.000 19.49442  ? 164 PHE A CB   1 
ATOM   2527 C CG   . PHE A 1 167 ? 41.38106 -5.16943  15.83958 1.000 20.64246  ? 164 PHE A CG   1 
ATOM   2528 C CD1  . PHE A 1 167 ? 41.66824 -6.06852  14.83662 1.000 20.37051  ? 164 PHE A CD1  1 
ATOM   2529 C CD2  . PHE A 1 167 ? 40.05247 -4.93066  16.15643 1.000 20.75105  ? 164 PHE A CD2  1 
ATOM   2530 C CE1  . PHE A 1 167 ? 40.65949 -6.69255  14.13817 1.000 20.09004  ? 164 PHE A CE1  1 
ATOM   2531 C CE2  . PHE A 1 167 ? 39.03231 -5.55130  15.46566 1.000 20.45487  ? 164 PHE A CE2  1 
ATOM   2532 C CZ   . PHE A 1 167 ? 39.34041 -6.43662  14.44244 1.000 21.21908  ? 164 PHE A CZ   1 
ATOM   2533 H H    . PHE A 1 167 ? 44.17884 -3.21309  17.60977 1.000 21.79572  ? 164 PHE A H    1 
ATOM   2534 H HA   . PHE A 1 167 ? 43.84932 -4.04425  15.16868 1.000 23.41339  ? 164 PHE A HA   1 
ATOM   2535 H HB2  . PHE A 1 167 ? 43.03448 -5.22920  16.98657 1.000 23.41228  ? 164 PHE A HB2  1 
ATOM   2536 H HB3  . PHE A 1 167 ? 42.05713 -4.03211  17.35694 1.000 23.41228  ? 164 PHE A HB3  1 
ATOM   2537 H HD1  . PHE A 1 167 ? 42.55498 -6.25643  14.62859 1.000 24.46360  ? 164 PHE A HD1  1 
ATOM   2538 H HD2  . PHE A 1 167 ? 39.84561 -4.34220  16.84623 1.000 24.92025  ? 164 PHE A HD2  1 
ATOM   2539 H HE1  . PHE A 1 167 ? 40.86952 -7.29013  13.45723 1.000 24.12703  ? 164 PHE A HE1  1 
ATOM   2540 H HE2  . PHE A 1 167 ? 38.14512 -5.37776  15.68399 1.000 24.56483  ? 164 PHE A HE2  1 
ATOM   2541 H HZ   . PHE A 1 167 ? 38.66057 -6.85464  13.96498 1.000 25.48188  ? 164 PHE A HZ   1 
ATOM   2542 N N    . ALA A 1 168 ? 41.94699 -1.56780  15.88300 1.000 20.85391  ? 165 ALA A N    1 
ATOM   2543 C CA   . ALA A 1 168 ? 41.08811 -0.55440  15.27073 1.000 19.55174  ? 165 ALA A CA   1 
ATOM   2544 C C    . ALA A 1 168 ? 41.88359 0.39531   14.37999 1.000 21.24571  ? 165 ALA A C    1 
ATOM   2545 O O    . ALA A 1 168 ? 41.42870 0.77477   13.28777 1.000 19.60490  ? 165 ALA A O    1 
ATOM   2546 C CB   . ALA A 1 168 ? 40.35649 0.22939   16.35918 1.000 19.43973  ? 165 ALA A CB   1 
ATOM   2547 H H    . ALA A 1 168 ? 42.01666 -1.50853  16.73812 1.000 25.04368  ? 165 ALA A H    1 
ATOM   2548 H HA   . ALA A 1 168 ? 40.43002 -1.00159  14.71590 1.000 23.48107  ? 165 ALA A HA   1 
ATOM   2549 H HB1  . ALA A 1 168 ? 39.78565 0.89284   15.94101 1.000 23.34665  ? 165 ALA A HB1  1 
ATOM   2550 H HB2  . ALA A 1 168 ? 39.81997 -0.38494  16.88421 1.000 23.34665  ? 165 ALA A HB2  1 
ATOM   2551 H HB3  . ALA A 1 168 ? 41.01019 0.66628   16.92725 1.000 23.34665  ? 165 ALA A HB3  1 
ATOM   2552 N N    . LEU A 1 169 ? 43.06609 0.81287   14.83623 1.000 18.83952  ? 166 LEU A N    1 
ATOM   2553 C CA   . LEU A 1 169 ? 43.87462 1.70975   14.01351 1.000 22.39410  ? 166 LEU A CA   1 
ATOM   2554 C C    . LEU A 1 169 ? 44.36715 1.02489   12.74320 1.000 23.03648  ? 166 LEU A C    1 
ATOM   2555 O O    . LEU A 1 169 ? 44.55167 1.68941   11.71936 1.000 21.92839  ? 166 LEU A O    1 
ATOM   2556 C CB   . LEU A 1 169 ? 45.05372 2.24695   14.81729 1.000 22.99316  ? 166 LEU A CB   1 
ATOM   2557 C CG   . LEU A 1 169 ? 44.68316 3.25926   15.91885 1.000 25.47915  ? 166 LEU A CG   1 
ATOM   2558 C CD1  . LEU A 1 169 ? 45.87160 3.57167   16.79636 1.000 27.15871  ? 166 LEU A CD1  1 
ATOM   2559 C CD2  . LEU A 1 169 ? 44.12953 4.53428   15.28566 1.000 28.62618  ? 166 LEU A CD2  1 
ATOM   2560 H H    . LEU A 1 169 ? 43.41145 0.59830   15.59404 1.000 22.62640  ? 166 LEU A H    1 
ATOM   2561 H HA   . LEU A 1 169 ? 43.32454 2.46439   13.75115 1.000 26.89190  ? 166 LEU A HA   1 
ATOM   2562 H HB2  . LEU A 1 169 ? 45.49834 1.49908   15.24615 1.000 27.61077  ? 166 LEU A HB2  1 
ATOM   2563 H HB3  . LEU A 1 169 ? 45.66388 2.69017   14.20725 1.000 27.61077  ? 166 LEU A HB3  1 
ATOM   2564 H HG   . LEU A 1 169 ? 43.99953 2.87197   16.48767 1.000 30.59396  ? 166 LEU A HG   1 
ATOM   2565 H HD11 . LEU A 1 169 ? 45.60718 4.22097   17.46673 1.000 32.60944  ? 166 LEU A HD11 1 
ATOM   2566 H HD12 . LEU A 1 169 ? 46.16999 2.75502   17.22641 1.000 32.60944  ? 166 LEU A HD12 1 
ATOM   2567 H HD13 . LEU A 1 169 ? 46.58331 3.93505   16.24651 1.000 32.60944  ? 166 LEU A HD13 1 
ATOM   2568 H HD21 . LEU A 1 169 ? 44.13245 5.24285   15.94810 1.000 34.37040  ? 166 LEU A HD21 1 
ATOM   2569 H HD22 . LEU A 1 169 ? 44.68963 4.78230   14.53355 1.000 34.37040  ? 166 LEU A HD22 1 
ATOM   2570 H HD23 . LEU A 1 169 ? 43.22312 4.36853   14.98260 1.000 34.37040  ? 166 LEU A HD23 1 
ATOM   2571 N N    . ALA A 1 170 ? 44.59759 -0.29052  12.78998 1.000 22.42434  ? 167 ALA A N    1 
ATOM   2572 C CA   . ALA A 1 170 ? 44.95688 -1.02424  11.57829 1.000 23.79788  ? 167 ALA A CA   1 
ATOM   2573 C C    . ALA A 1 170 ? 43.82761 -0.98720  10.55981 1.000 23.98331  ? 167 ALA A C    1 
ATOM   2574 O O    . ALA A 1 170 ? 44.07649 -0.87063  9.35449  1.000 23.28667  ? 167 ALA A O    1 
ATOM   2575 C CB   . ALA A 1 170 ? 45.31488 -2.47330  11.91487 1.000 24.15046  ? 167 ALA A CB   1 
ATOM   2576 H H    . ALA A 1 170 ? 44.55292 -0.77319  13.50036 1.000 26.92818  ? 167 ALA A H    1 
ATOM   2577 H HA   . ALA A 1 170 ? 45.73949 -0.60518  11.18738 1.000 28.57643  ? 167 ALA A HA   1 
ATOM   2578 H HB1  . ALA A 1 170 ? 45.55623 -2.93694  11.09775 1.000 28.99954  ? 167 ALA A HB1  1 
ATOM   2579 H HB2  . ALA A 1 170 ? 46.06353 -2.47854  12.53164 1.000 28.99954  ? 167 ALA A HB2  1 
ATOM   2580 H HB3  . ALA A 1 170 ? 44.54655 -2.90164  12.32364 1.000 28.99954  ? 167 ALA A HB3  1 
ATOM   2581 N N    . ILE A 1 171 ? 42.57957 -1.08071  11.02810 1.000 22.90340  ? 168 ILE A N    1 
ATOM   2582 C CA   . ILE A 1 171 ? 41.43116 -0.96426  10.13402 1.000 23.42373  ? 168 ILE A CA   1 
ATOM   2583 C C    . ILE A 1 171 ? 41.40143 0.42097   9.50367  1.000 25.35019  ? 168 ILE A C    1 
ATOM   2584 O O    . ILE A 1 171 ? 41.22106 0.56374   8.28948  1.000 25.14527  ? 168 ILE A O    1 
ATOM   2585 C CB   . ILE A 1 171 ? 40.12458 -1.25426  10.89336 1.000 22.95218  ? 168 ILE A CB   1 
ATOM   2586 C CG1  . ILE A 1 171 ? 40.07949 -2.70002  11.36378 1.000 22.75083  ? 168 ILE A CG1  1 
ATOM   2587 C CG2  . ILE A 1 171 ? 38.91738 -0.94839  10.01892 1.000 23.99256  ? 168 ILE A CG2  1 
ATOM   2588 C CD1  . ILE A 1 171 ? 38.91573 -3.01766  12.28501 1.000 20.75258  ? 168 ILE A CD1  1 
ATOM   2589 H H    . ILE A 1 171 ? 42.37452 -1.21040  11.85316 1.000 27.50306  ? 168 ILE A H    1 
ATOM   2590 H HA   . ILE A 1 171 ? 41.52212 -1.62296  9.42780  1.000 28.12746  ? 168 ILE A HA   1 
ATOM   2591 H HB   . ILE A 1 171 ? 40.10083 -0.67737  11.67281 1.000 27.56160  ? 168 ILE A HB   1 
ATOM   2592 H HG12 . ILE A 1 171 ? 40.00618 -3.27682  10.58736 1.000 27.31998  ? 168 ILE A HG12 1 
ATOM   2593 H HG13 . ILE A 1 171 ? 40.89826 -2.89514  11.84591 1.000 27.31998  ? 168 ILE A HG13 1 
ATOM   2594 H HG21 . ILE A 1 171 ? 38.11633 -1.26632  10.46405 1.000 28.81006  ? 168 ILE A HG21 1 
ATOM   2595 H HG22 . ILE A 1 171 ? 38.86137 0.01026   9.88202  1.000 28.81006  ? 168 ILE A HG22 1 
ATOM   2596 H HG23 . ILE A 1 171 ? 39.02284 -1.39869  9.16627  1.000 28.81006  ? 168 ILE A HG23 1 
ATOM   2597 H HD11 . ILE A 1 171 ? 39.08765 -3.86140  12.73161 1.000 24.92208  ? 168 ILE A HD11 1 
ATOM   2598 H HD12 . ILE A 1 171 ? 38.82911 -2.30802  12.94061 1.000 24.92208  ? 168 ILE A HD12 1 
ATOM   2599 H HD13 . ILE A 1 171 ? 38.10403 -3.08182  11.75782 1.000 24.92208  ? 168 ILE A HD13 1 
ATOM   2600 N N    . VAL A 1 172 ? 41.58872 1.46484   10.32084 1.000 24.51843  ? 169 VAL A N    1 
ATOM   2601 C CA   . VAL A 1 172 ? 41.59135 2.82974   9.79666  1.000 23.28489  ? 169 VAL A CA   1 
ATOM   2602 C C    . VAL A 1 172 ? 42.68342 2.98647   8.74608  1.000 26.86089  ? 169 VAL A C    1 
ATOM   2603 O O    . VAL A 1 172 ? 42.46276 3.55980   7.67441  1.000 26.18606  ? 169 VAL A O    1 
ATOM   2604 C CB   . VAL A 1 172 ? 41.75850 3.84700   10.94115 1.000 23.02576  ? 169 VAL A CB   1 
ATOM   2605 C CG1  . VAL A 1 172 ? 41.92447 5.25093   10.39622 1.000 24.62798  ? 169 VAL A CG1  1 
ATOM   2606 C CG2  . VAL A 1 172 ? 40.55885 3.76568   11.89297 1.000 22.21433  ? 169 VAL A CG2  1 
ATOM   2607 H H    . VAL A 1 172 ? 41.71440 1.40804   11.16971 1.000 29.44109  ? 169 VAL A H    1 
ATOM   2608 H HA   . VAL A 1 172 ? 40.73655 2.99884   9.37050  1.000 27.96085  ? 169 VAL A HA   1 
ATOM   2609 H HB   . VAL A 1 172 ? 42.56149 3.63271   11.44133 1.000 27.64990  ? 169 VAL A HB   1 
ATOM   2610 H HG11 . VAL A 1 172 ? 41.76187 5.88783   11.10953 1.000 29.57255  ? 169 VAL A HG11 1 
ATOM   2611 H HG12 . VAL A 1 172 ? 42.82847 5.35440   10.06009 1.000 29.57255  ? 169 VAL A HG12 1 
ATOM   2612 H HG13 . VAL A 1 172 ? 41.28685 5.38845   9.67828  1.000 29.57255  ? 169 VAL A HG13 1 
ATOM   2613 H HG21 . VAL A 1 172 ? 40.68576 4.39983   12.61591 1.000 26.67618  ? 169 VAL A HG21 1 
ATOM   2614 H HG22 . VAL A 1 172 ? 39.75076 3.98147   11.40172 1.000 26.67618  ? 169 VAL A HG22 1 
ATOM   2615 H HG23 . VAL A 1 172 ? 40.49890 2.86549   12.24930 1.000 26.67618  ? 169 VAL A HG23 1 
ATOM   2616 N N    . GLU A 1 173 ? 43.88619 2.49607   9.04932  1.000 25.43589  ? 170 GLU A N    1 
ATOM   2617 C CA   . GLU A 1 173 ? 44.99058 2.58395   8.09843  1.000 29.48315  ? 170 GLU A CA   1 
ATOM   2618 C C    . GLU A 1 173 ? 44.65573 1.88050   6.78947  1.000 31.00413  ? 170 GLU A C    1 
ATOM   2619 O O    . GLU A 1 173 ? 44.94101 2.40456   5.70829  1.000 31.18835  ? 170 GLU A O    1 
ATOM   2620 C CB   . GLU A 1 173 ? 46.25554 1.99658   8.72761  1.000 32.82923  ? 170 GLU A CB   1 
ATOM   2621 C CG   . GLU A 1 173 ? 47.50277 2.10754   7.89328  1.000 46.44979  ? 170 GLU A CG   1 
ATOM   2622 C CD   . GLU A 1 173 ? 48.74023 1.72050   8.67749  1.000 56.97614  ? 170 GLU A CD   1 
ATOM   2623 O OE1  . GLU A 1 173 ? 48.79754 2.02493   9.88854  1.000 56.11621  ? 170 GLU A OE1  1 
ATOM   2624 O OE2  . GLU A 1 173 ? 49.65224 1.11509   8.08201  1.000 63.42812  ? 170 GLU A OE2  1 
ATOM   2625 H H    . GLU A 1 173 ? 44.08653 2.11141   9.79195  1.000 30.54206  ? 170 GLU A H    1 
ATOM   2626 H HA   . GLU A 1 173 ? 45.15949 3.51659   7.89216  1.000 35.39876  ? 170 GLU A HA   1 
ATOM   2627 H HB2  . GLU A 1 173 ? 46.42443 2.45967   9.56303  1.000 39.41405  ? 170 GLU A HB2  1 
ATOM   2628 H HB3  . GLU A 1 173 ? 46.10329 1.05351   8.89596  1.000 39.41405  ? 170 GLU A HB3  1 
ATOM   2629 H HG2  . GLU A 1 173 ? 47.42979 1.51520   7.12861  1.000 55.75873  ? 170 GLU A HG2  1 
ATOM   2630 H HG3  . GLU A 1 173 ? 47.60686 3.02433   7.59401  1.000 55.75873  ? 170 GLU A HG3  1 
ATOM   2631 N N    . ALA A 1 174 ? 44.03546 0.70370   6.86658  1.000 27.14566  ? 171 ALA A N    1 
ATOM   2632 C CA   . ALA A 1 174 ? 43.69496 -0.03771  5.65979  1.000 30.76319  ? 171 ALA A CA   1 
ATOM   2633 C C    . ALA A 1 174 ? 42.65953 0.70080   4.82953  1.000 33.27417  ? 171 ALA A C    1 
ATOM   2634 O O    . ALA A 1 174 ? 42.72018 0.67698   3.59880  1.000 32.34486  ? 171 ALA A O    1 
ATOM   2635 C CB   . ALA A 1 174 ? 43.17617 -1.42703  6.02778  1.000 26.96162  ? 171 ALA A CB   1 
ATOM   2636 H H    A ALA A 1 174 ? 43.80359 0.31750   7.59917  0.530 32.59377  ? 171 ALA A H    1 
ATOM   2637 H H    B ALA A 1 174 ? 43.80359 0.31750   7.59917  0.470 32.59377  ? 171 ALA A H    1 
ATOM   2638 H HA   . ALA A 1 174 ? 44.49760 -0.14068  5.12494  1.000 36.93481  ? 171 ALA A HA   1 
ATOM   2639 H HB1  . ALA A 1 174 ? 42.96485 -1.91096  5.21412  1.000 32.37292  ? 171 ALA A HB1  1 
ATOM   2640 H HB2  . ALA A 1 174 ? 43.86264 -1.89910  6.52459  1.000 32.37292  ? 171 ALA A HB2  1 
ATOM   2641 H HB3  . ALA A 1 174 ? 42.37937 -1.33246  6.57281  1.000 32.37292  ? 171 ALA A HB3  1 
ATOM   2642 N N    . LEU A 1 175 ? 41.70185 1.35641   5.47989  1.000 29.95232  ? 172 LEU A N    1 
ATOM   2643 C CA   . LEU A 1 175 ? 40.61479 2.03064   4.78369  1.000 30.62642  ? 172 LEU A CA   1 
ATOM   2644 C C    . LEU A 1 175 ? 40.97788 3.45838   4.38485  1.000 34.11634  ? 172 LEU A C    1 
ATOM   2645 O O    . LEU A 1 175 ? 40.77092 3.84784   3.23181  1.000 34.20160  ? 172 LEU A O    1 
ATOM   2646 C CB   . LEU A 1 175 ? 39.36748 2.03805   5.66937  1.000 31.08447  ? 172 LEU A CB   1 
ATOM   2647 C CG   . LEU A 1 175 ? 38.36464 0.91129   5.44269  1.000 35.06414  ? 172 LEU A CG   1 
ATOM   2648 C CD1  . LEU A 1 175 ? 39.07646 -0.39514  5.28518  1.000 34.52887  ? 172 LEU A CD1  1 
ATOM   2649 C CD2  . LEU A 1 175 ? 37.33720 0.83900   6.56209  1.000 32.74857  ? 172 LEU A CD2  1 
ATOM   2650 H H    . LEU A 1 175 ? 41.66027 1.42525   6.33613  1.000 35.96177  ? 172 LEU A H    1 
ATOM   2651 H HA   . LEU A 1 175 ? 40.41645 1.53971   3.97094  1.000 36.77069  ? 172 LEU A HA   1 
ATOM   2652 H HB2  . LEU A 1 175 ? 39.65529 1.98166   6.59397  1.000 37.32035  ? 172 LEU A HB2  1 
ATOM   2653 H HB3  . LEU A 1 175 ? 38.89704 2.87284   5.51867  1.000 37.32035  ? 172 LEU A HB3  1 
ATOM   2654 H HG   . LEU A 1 175 ? 37.87757 1.09431   4.62405  1.000 42.09595  ? 172 LEU A HG   1 
ATOM   2655 H HD11 . LEU A 1 175 ? 38.43888 -1.11762  5.39662  1.000 41.45362  ? 172 LEU A HD11 1 
ATOM   2656 H HD12 . LEU A 1 175 ? 39.47049 -0.43535  4.39973  1.000 41.45362  ? 172 LEU A HD12 1 
ATOM   2657 H HD13 . LEU A 1 175 ? 39.77078 -0.45977  5.95945  1.000 41.45362  ? 172 LEU A HD13 1 
ATOM   2658 H HD21 . LEU A 1 175 ? 36.69043 0.14702   6.35291  1.000 39.31726  ? 172 LEU A HD21 1 
ATOM   2659 H HD22 . LEU A 1 175 ? 37.79024 0.62793   7.39342  1.000 39.31726  ? 172 LEU A HD22 1 
ATOM   2660 H HD23 . LEU A 1 175 ? 36.89103 1.69702   6.63712  1.000 39.31726  ? 172 LEU A HD23 1 
ATOM   2661 N N    . ASN A 1 176 ? 41.52243 4.24878   5.31688  1.000 31.35511  ? 173 ASN A N    1 
ATOM   2662 C CA   . ASN A 1 176 ? 41.71765 5.67395   5.09121  1.000 31.28025  ? 173 ASN A CA   1 
ATOM   2663 C C    . ASN A 1 176 ? 43.17359 6.09580   4.96326  1.000 32.29398  ? 173 ASN A C    1 
ATOM   2664 O O    . ASN A 1 176 ? 43.43286 7.26977   4.67409  1.000 33.43219  ? 173 ASN A O    1 
ATOM   2665 C CB   . ASN A 1 176 ? 41.07408 6.48483   6.22655  1.000 31.80494  ? 173 ASN A CB   1 
ATOM   2666 C CG   . ASN A 1 176 ? 39.58709 6.23682   6.36088  1.000 40.04465  ? 173 ASN A CG   1 
ATOM   2667 O OD1  . ASN A 1 176 ? 39.06797 6.11117   7.46832  1.000 57.60007  ? 173 ASN A OD1  1 
ATOM   2668 N ND2  . ASN A 1 176 ? 38.89394 6.17276   5.23741  1.000 45.32074  ? 173 ASN A ND2  1 
ATOM   2669 H H    . ASN A 1 176 ? 41.78590 3.97638   6.08887  1.000 37.64512  ? 173 ASN A H    1 
ATOM   2670 H HA   . ASN A 1 176 ? 41.27534 5.90223   4.25866  1.000 37.55529  ? 173 ASN A HA   1 
ATOM   2671 H HB2  . ASN A 1 176 ? 41.49483 6.24091   7.06582  1.000 38.18490  ? 173 ASN A HB2  1 
ATOM   2672 H HB3  . ASN A 1 176 ? 41.20494 7.43002   6.05221  1.000 38.18490  ? 173 ASN A HB3  1 
ATOM   2673 H HD21 . ASN A 1 176 ? 38.04567 6.03350   5.26285  1.000 54.40386  ? 173 ASN A HD21 1 
ATOM   2674 H HD22 . ASN A 1 176 ? 39.29118 6.27032   4.48091  1.000 54.40386  ? 173 ASN A HD22 1 
ATOM   2675 N N    . GLY A 1 177 ? 44.12449 5.20337   5.19591  1.000 30.07169  ? 174 GLY A N    1 
ATOM   2676 C CA   . GLY A 1 177 ? 45.52246 5.52756   5.00521  1.000 31.10927  ? 174 GLY A CA   1 
ATOM   2677 C C    . GLY A 1 177 ? 46.23962 5.86441   6.30252  1.000 37.26111  ? 174 GLY A C    1 
ATOM   2678 O O    . GLY A 1 177 ? 45.63997 6.08032   7.35765  1.000 31.00694  ? 174 GLY A O    1 
ATOM   2679 H H    . GLY A 1 177 ? 43.98082 4.39973   5.46631  1.000 36.10501  ? 174 GLY A H    1 
ATOM   2680 H HA2  . GLY A 1 177 ? 45.97218 4.77024   4.59886  1.000 37.35010  ? 174 GLY A HA2  1 
ATOM   2681 H HA3  . GLY A 1 177 ? 45.59384 6.29231   4.41279  1.000 37.35010  ? 174 GLY A HA3  1 
ATOM   2682 N N    . LYS A 1 178 ? 47.56816 5.93624   6.18816  1.000 33.60444  ? 175 LYS A N    1 
ATOM   2683 C CA   . LYS A 1 178 ? 48.42348 6.08412   7.36270  1.000 40.81987  ? 175 LYS A CA   1 
ATOM   2684 C C    . LYS A 1 178 ? 48.23527 7.44009   8.03474  1.000 37.49080  ? 175 LYS A C    1 
ATOM   2685 O O    . LYS A 1 178 ? 48.28775 7.53926   9.26651  1.000 33.91098  ? 175 LYS A O    1 
ATOM   2686 C CB   . LYS A 1 178 ? 49.89684 5.90755   6.97491  1.000 45.42038  ? 175 LYS A CB   1 
ATOM   2687 C CG   . LYS A 1 178 ? 50.17982 4.78482   5.99467  1.000 88.33841  ? 175 LYS A CG   1 
ATOM   2688 C CD   . LYS A 1 178 ? 50.60843 3.49837   6.69933  1.000 96.37546  ? 175 LYS A CD   1 
ATOM   2689 C CE   . LYS A 1 178 ? 52.12811 3.34952   6.73706  1.000 106.96929 ? 175 LYS A CE   1 
ATOM   2690 N NZ   . LYS A 1 178 ? 52.53066 1.99784   7.22893  1.000 116.58532 ? 175 LYS A NZ   1 
ATOM   2691 H H    . LYS A 1 178 ? 47.99695 5.90180   5.44348  1.000 40.34431  ? 175 LYS A H    1 
ATOM   2692 H HA   . LYS A 1 178 ? 48.18029 5.39018   7.99533  1.000 49.00282  ? 175 LYS A HA   1 
ATOM   2693 H HB2  . LYS A 1 178 ? 50.20680 6.73182   6.56823  1.000 54.52344  ? 175 LYS A HB2  1 
ATOM   2694 H HB3  . LYS A 1 178 ? 50.40500 5.72345   7.78038  1.000 54.52344  ? 175 LYS A HB3  1 
ATOM   2695 H HG2  . LYS A 1 178 ? 49.37629 4.59664   5.48494  1.000 106.02507 ? 175 LYS A HG2  1 
ATOM   2696 H HG3  . LYS A 1 178 ? 50.89536 5.05525   5.39820  1.000 106.02507 ? 175 LYS A HG3  1 
ATOM   2697 H HD2  . LYS A 1 178 ? 50.28206 3.50995   7.61270  1.000 115.66953 ? 175 LYS A HD2  1 
ATOM   2698 H HD3  . LYS A 1 178 ? 50.24071 2.73618   6.22526  1.000 115.66953 ? 175 LYS A HD3  1 
ATOM   2699 H HE2  . LYS A 1 178 ? 52.48516 3.46818   5.84301  1.000 128.38213 ? 175 LYS A HE2  1 
ATOM   2700 H HE3  . LYS A 1 178 ? 52.50178 4.01594   7.33469  1.000 128.38213 ? 175 LYS A HE3  1 
ATOM   2701 H HZ1  . LYS A 1 178 ? 52.23263 1.87455   8.05843  1.000 139.92137 ? 175 LYS A HZ1  1 
ATOM   2702 H HZ2  . LYS A 1 178 ? 52.18781 1.36768   6.70218  1.000 139.92137 ? 175 LYS A HZ2  1 
ATOM   2703 H HZ3  . LYS A 1 178 ? 53.41767 1.92489   7.22688  1.000 139.92137 ? 175 LYS A HZ3  1 
ATOM   2704 N N    . GLU A 1 179 ? 48.03632 8.49977   7.24744  1.000 35.79511  ? 176 GLU A N    1 
ATOM   2705 C CA   A GLU A 1 179 ? 47.96716 9.83804   7.82463  0.468 38.03971  ? 176 GLU A CA   1 
ATOM   2706 C CA   B GLU A 1 179 ? 47.96473 9.83975   7.82153  0.532 38.00994  ? 176 GLU A CA   1 
ATOM   2707 C C    . GLU A 1 179 ? 46.71763 10.00678  8.67661  1.000 32.59670  ? 176 GLU A C    1 
ATOM   2708 O O    . GLU A 1 179 ? 46.78640 10.56252  9.77523  1.000 30.07385  ? 176 GLU A O    1 
ATOM   2709 C CB   A GLU A 1 179 ? 48.01965 10.88425  6.71243  0.468 45.57321  ? 176 GLU A CB   1 
ATOM   2710 C CB   B GLU A 1 179 ? 47.98824 10.89575  6.71727  0.532 45.52666  ? 176 GLU A CB   1 
ATOM   2711 C CG   A GLU A 1 179 ? 49.32969 10.85172  5.92615  0.468 55.71789  ? 176 GLU A CG   1 
ATOM   2712 C CG   B GLU A 1 179 ? 48.02723 12.32915  7.23918  0.532 51.53258  ? 176 GLU A CG   1 
ATOM   2713 C CD   A GLU A 1 179 ? 49.31472 11.74317  4.69957  0.468 72.63106  ? 176 GLU A CD   1 
ATOM   2714 C CD   B GLU A 1 179 ? 48.11623 13.36480  6.13073  0.532 65.44602  ? 176 GLU A CD   1 
ATOM   2715 O OE1  A GLU A 1 179 ? 48.63855 12.79379  4.72788  0.468 83.94631  ? 176 GLU A OE1  1 
ATOM   2716 O OE1  B GLU A 1 179 ? 47.48672 13.16706  5.06868  0.532 71.01035  ? 176 GLU A OE1  1 
ATOM   2717 O OE2  A GLU A 1 179 ? 49.97758 11.38682  3.70181  0.468 68.37700  ? 176 GLU A OE2  1 
ATOM   2718 O OE2  B GLU A 1 179 ? 48.82562 14.37552  6.31909  0.532 65.00252  ? 176 GLU A OE2  1 
ATOM   2719 H H    A GLU A 1 179 ? 47.94040 8.46978   6.39334  0.468 42.97311  ? 176 GLU A H    1 
ATOM   2720 H H    B GLU A 1 179 ? 47.94153 8.46899   6.39324  0.532 42.97311  ? 176 GLU A H    1 
ATOM   2721 H HA   A GLU A 1 179 ? 48.73555 9.97687   8.40014  0.468 45.66663  ? 176 GLU A HA   1 
ATOM   2722 H HA   B GLU A 1 179 ? 48.74420 9.97329   8.38321  0.532 45.63090  ? 176 GLU A HA   1 
ATOM   2723 H HB2  A GLU A 1 179 ? 47.29304 10.72026  6.09111  0.468 54.70683  ? 176 GLU A HB2  1 
ATOM   2724 H HB2  B GLU A 1 179 ? 48.77760 10.75791  6.17063  0.532 54.65097  ? 176 GLU A HB2  1 
ATOM   2725 H HB3  A GLU A 1 179 ? 47.92763 11.76641  7.10514  0.468 54.70683  ? 176 GLU A HB3  1 
ATOM   2726 H HB3  B GLU A 1 179 ? 47.18899 10.79909  6.17620  0.532 54.65097  ? 176 GLU A HB3  1 
ATOM   2727 H HG2  A GLU A 1 179 ? 50.04976 11.15111  6.50301  0.468 66.88045  ? 176 GLU A HG2  1 
ATOM   2728 H HG2  B GLU A 1 179 ? 47.21785 12.50212  7.74504  0.532 61.85807  ? 176 GLU A HG2  1 
ATOM   2729 H HG3  A GLU A 1 179 ? 49.49671 9.94275   5.63156  0.468 66.88045  ? 176 GLU A HG3  1 
ATOM   2730 H HG3  B GLU A 1 179 ? 48.80427 12.43532  7.81000  0.532 61.85807  ? 176 GLU A HG3  1 
ATOM   2731 N N    . VAL A 1 180 ? 45.56546 9.53359   8.19359  1.000 29.36390  ? 177 VAL A N    1 
ATOM   2732 C CA   . VAL A 1 180 ? 44.35508 9.62616   9.00891  1.000 29.10784  ? 177 VAL A CA   1 
ATOM   2733 C C    . VAL A 1 180 ? 44.51923 8.83632   10.30495 1.000 27.22742  ? 177 VAL A C    1 
ATOM   2734 O O    . VAL A 1 180 ? 44.13800 9.29897   11.38600 1.000 26.06464  ? 177 VAL A O    1 
ATOM   2735 C CB   . VAL A 1 180 ? 43.13042 9.15022   8.20779  1.000 31.36670  ? 177 VAL A CB   1 
ATOM   2736 C CG1  . VAL A 1 180 ? 41.92751 9.01170   9.10781  1.000 29.00095  ? 177 VAL A CG1  1 
ATOM   2737 C CG2  . VAL A 1 180 ? 42.83426 10.12274  7.07052  1.000 31.73044  ? 177 VAL A CG2  1 
ATOM   2738 H H    . VAL A 1 180 ? 45.46210 9.16678   7.42263  1.000 35.25566  ? 177 VAL A H    1 
ATOM   2739 H HA   . VAL A 1 180 ? 44.21607 10.55713  9.24315  1.000 34.94839  ? 177 VAL A HA   1 
ATOM   2740 H HB   . VAL A 1 180 ? 43.32367 8.27942   7.82666  1.000 37.65902  ? 177 VAL A HB   1 
ATOM   2741 H HG11 . VAL A 1 180 ? 41.12687 8.97496   8.56144  1.000 34.82012  ? 177 VAL A HG11 1 
ATOM   2742 H HG12 . VAL A 1 180 ? 42.01257 8.19569   9.62529  1.000 34.82012  ? 177 VAL A HG12 1 
ATOM   2743 H HG13 . VAL A 1 180 ? 41.88772 9.77748   9.70186  1.000 34.82012  ? 177 VAL A HG13 1 
ATOM   2744 H HG21 . VAL A 1 180 ? 42.08255 9.78832   6.55671  1.000 38.09551  ? 177 VAL A HG21 1 
ATOM   2745 H HG22 . VAL A 1 180 ? 42.61853 10.99092  7.44552  1.000 38.09551  ? 177 VAL A HG22 1 
ATOM   2746 H HG23 . VAL A 1 180 ? 43.61775 10.19300  6.50298  1.000 38.09551  ? 177 VAL A HG23 1 
ATOM   2747 N N    . ALA A 1 181 ? 45.05835 7.62189   10.21472 1.000 27.60483  ? 178 ALA A N    1 
ATOM   2748 C CA   . ALA A 1 181 ? 45.26450 6.81409   11.41159 1.000 27.82852  ? 178 ALA A CA   1 
ATOM   2749 C C    . ALA A 1 181 ? 46.14640 7.54004   12.41316 1.000 27.55318  ? 178 ALA A C    1 
ATOM   2750 O O    . ALA A 1 181 ? 45.87772 7.51270   13.61951 1.000 26.07208  ? 178 ALA A O    1 
ATOM   2751 C CB   . ALA A 1 181 ? 45.88508 5.46705   11.03927 1.000 29.88220  ? 178 ALA A CB   1 
ATOM   2752 H H    . ALA A 1 181 ? 45.30990 7.24775   9.48237  1.000 33.14478  ? 178 ALA A H    1 
ATOM   2753 H HA   . ALA A 1 181 ? 44.40372 6.64523   11.82565 1.000 33.41321  ? 178 ALA A HA   1 
ATOM   2754 H HB1  . ALA A 1 181 ? 46.01297 4.94440   11.84635 1.000 35.87762  ? 178 ALA A HB1  1 
ATOM   2755 H HB2  . ALA A 1 181 ? 45.28744 5.00046   10.43427 1.000 35.87762  ? 178 ALA A HB2  1 
ATOM   2756 H HB3  . ALA A 1 181 ? 46.73930 5.62171   10.60650 1.000 35.87762  ? 178 ALA A HB3  1 
ATOM   2757 N N    . ALA A 1 182 ? 47.20060 8.20251   11.92704 1.000 26.38442  ? 179 ALA A N    1 
ATOM   2758 C CA   . ALA A 1 182 ? 48.08913 8.93994   12.81381 1.000 27.71432  ? 179 ALA A CA   1 
ATOM   2759 C C    . ALA A 1 182 ? 47.37771 10.13130  13.43721 1.000 27.19029  ? 179 ALA A C    1 
ATOM   2760 O O    . ALA A 1 182 ? 47.61268 10.45399  14.60806 1.000 24.26782  ? 179 ALA A O    1 
ATOM   2761 C CB   . ALA A 1 182 ? 49.33227 9.40245   12.05232 1.000 28.59271  ? 179 ALA A CB   1 
ATOM   2762 H H    . ALA A 1 182 ? 47.41777 8.23798   11.09567 1.000 31.68029  ? 179 ALA A H    1 
ATOM   2763 H HA   . ALA A 1 182 ? 48.37624 8.34844   13.52697 1.000 33.27616  ? 179 ALA A HA   1 
ATOM   2764 H HB1  . ALA A 1 182 ? 49.90863 9.89448   12.65780 1.000 34.33023  ? 179 ALA A HB1  1 
ATOM   2765 H HB2  . ALA A 1 182 ? 49.79984 8.62495   11.70913 1.000 34.33023  ? 179 ALA A HB2  1 
ATOM   2766 H HB3  . ALA A 1 182 ? 49.05839 9.97441   11.31833 1.000 34.33023  ? 179 ALA A HB3  1 
ATOM   2767 N N    . GLN A 1 183 ? 46.51479 10.80716  12.67074 1.000 24.98835  ? 180 GLN A N    1 
ATOM   2768 C CA   A GLN A 1 183 ? 45.78669 11.95904  13.19805 0.594 27.00961  ? 180 GLN A CA   1 
ATOM   2769 C CA   B GLN A 1 183 ? 45.81832 11.96090  13.22824 0.406 27.15257  ? 180 GLN A CA   1 
ATOM   2770 C C    . GLN A 1 183 ? 44.78528 11.52934  14.26342 1.000 25.11424  ? 180 GLN A C    1 
ATOM   2771 O O    . GLN A 1 183 ? 44.60946 12.20790  15.28268 1.000 25.96813  ? 180 GLN A O    1 
ATOM   2772 C CB   A GLN A 1 183 ? 45.06200 12.68788  12.06125 0.594 28.54299  ? 180 GLN A CB   1 
ATOM   2773 C CB   B GLN A 1 183 ? 45.17798 12.78216  12.10979 0.406 28.87580  ? 180 GLN A CB   1 
ATOM   2774 C CG   A GLN A 1 183 ? 45.96794 13.28405  10.98640 0.594 31.14975  ? 180 GLN A CG   1 
ATOM   2775 C CG   B GLN A 1 183 ? 46.19786 13.60547  11.32043 0.406 31.18454  ? 180 GLN A CG   1 
ATOM   2776 C CD   A GLN A 1 183 ? 45.20199 13.68562  9.72321  0.594 35.62544  ? 180 GLN A CD   1 
ATOM   2777 C CD   B GLN A 1 183 ? 46.95083 14.59811  12.18964 0.406 31.89862  ? 180 GLN A CD   1 
ATOM   2778 O OE1  A GLN A 1 183 ? 44.01098 13.38439  9.56755  0.594 32.93985  ? 180 GLN A OE1  1 
ATOM   2779 O OE1  B GLN A 1 183 ? 46.34919 15.41962  12.88382 0.406 30.92357  ? 180 GLN A OE1  1 
ATOM   2780 N NE2  A GLN A 1 183 ? 45.88996 14.36891  8.81469  0.594 43.46484  ? 180 GLN A NE2  1 
ATOM   2781 N NE2  B GLN A 1 183 ? 48.27645 14.51429  12.16639 0.406 33.89456  ? 180 GLN A NE2  1 
ATOM   2782 H H    A GLN A 1 183 ? 46.33600 10.61963  11.85070 0.594 30.00500  ? 180 GLN A H    1 
ATOM   2783 H H    B GLN A 1 183 ? 46.32357 10.62187  11.85300 0.406 30.00500  ? 180 GLN A H    1 
ATOM   2784 H HA   A GLN A 1 183 ? 46.42149 12.57331  13.59879 0.594 32.43051  ? 180 GLN A HA   1 
ATOM   2785 H HA   B GLN A 1 183 ? 46.46050 12.53444  13.67495 0.406 32.60207  ? 180 GLN A HA   1 
ATOM   2786 H HB2  A GLN A 1 183 ? 44.46882 12.05773  11.62311 0.594 34.27057  ? 180 GLN A HB2  1 
ATOM   2787 H HB2  B GLN A 1 183 ? 44.73421 12.18096  11.49131 0.406 34.66994  ? 180 GLN A HB2  1 
ATOM   2788 H HB3  A GLN A 1 183 ? 44.54819 13.41638  12.44359 0.594 34.27057  ? 180 GLN A HB3  1 
ATOM   2789 H HB3  B GLN A 1 183 ? 44.53328 13.39452  12.49745 0.406 34.66994  ? 180 GLN A HB3  1 
ATOM   2790 H HG2  A GLN A 1 183 ? 46.39919 14.07738  11.34073 0.594 37.39868  ? 180 GLN A HG2  1 
ATOM   2791 H HG2  B GLN A 1 183 ? 46.84623 13.00553  10.91968 0.406 37.44043  ? 180 GLN A HG2  1 
ATOM   2792 H HG3  A GLN A 1 183 ? 46.63614 12.62702  10.73599 0.594 37.39868  ? 180 GLN A HG3  1 
ATOM   2793 H HG3  B GLN A 1 183 ? 45.73475 14.10343  10.62872 0.406 37.44043  ? 180 GLN A HG3  1 
ATOM   2794 H HE21 A GLN A 1 183 ? 46.71652 14.56014  8.95553  0.594 52.17679  ? 180 GLN A HE21 1 
ATOM   2795 H HE21 B GLN A 1 183 ? 48.66128 13.92099  11.67699 0.406 40.69245  ? 180 GLN A HE21 1 
ATOM   2796 H HE22 A GLN A 1 183 ? 45.50868 14.61992  8.08585  0.594 52.17679  ? 180 GLN A HE22 1 
ATOM   2797 H HE22 B GLN A 1 183 ? 48.74978 15.05333  12.64072 0.406 40.69245  ? 180 GLN A HE22 1 
ATOM   2798 N N    . VAL A 1 184 ? 44.10418 10.40527  14.02868 1.000 23.56444  ? 181 VAL A N    1 
ATOM   2799 C CA   . VAL A 1 184 ? 43.13539 9.89710   14.98754 1.000 24.79161  ? 181 VAL A CA   1 
ATOM   2800 C C    . VAL A 1 184 ? 43.83557 9.38964   16.23318 1.000 23.94528  ? 181 VAL A C    1 
ATOM   2801 O O    . VAL A 1 184 ? 43.27707 9.45282   17.33325 1.000 22.64614  ? 181 VAL A O    1 
ATOM   2802 C CB   . VAL A 1 184 ? 42.28692 8.78869   14.33820 1.000 25.67675  ? 181 VAL A CB   1 
ATOM   2803 C CG1  . VAL A 1 184 ? 41.52052 8.01894   15.39804 1.000 28.44974  ? 181 VAL A CG1  1 
ATOM   2804 C CG2  . VAL A 1 184 ? 41.33985 9.38790   13.30656 1.000 28.08676  ? 181 VAL A CG2  1 
ATOM   2805 H H    . VAL A 1 184 ? 44.18703 9.92188   13.32223 1.000 28.29632  ? 181 VAL A H    1 
ATOM   2806 H HA   . VAL A 1 184 ? 42.54586 10.62225  15.24735 1.000 29.76891  ? 181 VAL A HA   1 
ATOM   2807 H HB   . VAL A 1 184 ? 42.87192 8.16360   13.88220 1.000 30.83109  ? 181 VAL A HB   1 
ATOM   2808 H HG11 . VAL A 1 184 ? 40.78504 7.54776   14.97619 1.000 34.15867  ? 181 VAL A HG11 1 
ATOM   2809 H HG12 . VAL A 1 184 ? 42.11930 7.38495   15.82279 1.000 34.15867  ? 181 VAL A HG12 1 
ATOM   2810 H HG13 . VAL A 1 184 ? 41.17876 8.64358   16.05678 1.000 34.15867  ? 181 VAL A HG13 1 
ATOM   2811 H HG21 . VAL A 1 184 ? 40.81812 8.67535   12.90535 1.000 33.72310  ? 181 VAL A HG21 1 
ATOM   2812 H HG22 . VAL A 1 184 ? 40.75157 10.02050  13.74776 1.000 33.72310  ? 181 VAL A HG22 1 
ATOM   2813 H HG23 . VAL A 1 184 ? 41.86080 9.84055   12.62493 1.000 33.72310  ? 181 VAL A HG23 1 
ATOM   2814 N N    . LYS A 1 185 ? 45.06462 8.88999   16.08925 1.000 23.89952  ? 182 LYS A N    1 
ATOM   2815 C CA   . LYS A 1 185 ? 45.75891 8.26715   17.21287 1.000 22.38180  ? 182 LYS A CA   1 
ATOM   2816 C C    . LYS A 1 185 ? 46.21642 9.29098   18.25316 1.000 25.63288  ? 182 LYS A C    1 
ATOM   2817 O O    . LYS A 1 185 ? 46.17593 9.01953   19.45938 1.000 22.85748  ? 182 LYS A O    1 
ATOM   2818 C CB   . LYS A 1 185 ? 46.94926 7.47259   16.68578 1.000 26.58550  ? 182 LYS A CB   1 
ATOM   2819 C CG   . LYS A 1 185 ? 47.81200 6.87306   17.78002 1.000 31.04359  ? 182 LYS A CG   1 
ATOM   2820 C CD   . LYS A 1 185 ? 49.00838 6.15784   17.16641 1.000 36.81786  ? 182 LYS A CD   1 
ATOM   2821 C CE   . LYS A 1 185 ? 49.88550 5.54912   18.24280 1.000 57.70947  ? 182 LYS A CE   1 
ATOM   2822 N NZ   . LYS A 1 185 ? 51.03776 4.81610   17.65554 1.000 66.61007  ? 182 LYS A NZ   1 
ATOM   2823 N N    . ALA A 1 186 ? 46.62127 10.48065  17.81553 1.000 25.28722  ? 183 ALA A N    1 
ATOM   2824 C CA   . ALA A 1 186 ? 47.30216 11.40579  18.72025 1.000 27.25351  ? 183 ALA A CA   1 
ATOM   2825 C C    . ALA A 1 186 ? 46.44906 11.79961  19.91614 1.000 27.20106  ? 183 ALA A C    1 
ATOM   2826 O O    . ALA A 1 186 ? 46.95850 11.75483  21.04656 1.000 27.03797  ? 183 ALA A O    1 
ATOM   2827 C CB   . ALA A 1 186 ? 47.77036 12.64213  17.94193 1.000 28.82092  ? 183 ALA A CB   1 
ATOM   2828 H H    . ALA A 1 186 ? 46.51674 10.77329  17.01364 1.000 30.36365  ? 183 ALA A H    1 
ATOM   2829 H HA   . ALA A 1 186 ? 48.08611 10.94753  19.06128 1.000 32.72319  ? 183 ALA A HA   1 
ATOM   2830 H HB1  . ALA A 1 186 ? 48.14193 13.28573  18.56531 1.000 34.60409  ? 183 ALA A HB1  1 
ATOM   2831 H HB2  . ALA A 1 186 ? 48.44701 12.37405  17.30069 1.000 34.60409  ? 183 ALA A HB2  1 
ATOM   2832 H HB3  . ALA A 1 186 ? 47.01129 13.03010  17.47912 1.000 34.60409  ? 183 ALA A HB3  1 
ATOM   2833 N N    . PRO A 1 187 ? 45.17446 12.16874  19.76769 1.000 23.97149  ? 184 PRO A N    1 
ATOM   2834 C CA   . PRO A 1 187 ? 44.38453 12.56633  20.94691 1.000 25.46611  ? 184 PRO A CA   1 
ATOM   2835 C C    . PRO A 1 187 ? 44.01136 11.40975  21.87167 1.000 24.19928  ? 184 PRO A C    1 
ATOM   2836 O O    . PRO A 1 187 ? 43.41509 11.64687  22.92716 1.000 21.01109  ? 184 PRO A O    1 
ATOM   2837 C CB   . PRO A 1 187 ? 43.12274 13.20503  20.33165 1.000 23.48200  ? 184 PRO A CB   1 
ATOM   2838 C CG   . PRO A 1 187 ? 43.44676 13.42305  18.88057 1.000 25.26211  ? 184 PRO A CG   1 
ATOM   2839 C CD   . PRO A 1 187 ? 44.44056 12.36449  18.50702 1.000 26.09072  ? 184 PRO A CD   1 
ATOM   2840 H HA   . PRO A 1 187 ? 44.86774 13.23785  21.45334 1.000 30.57832  ? 184 PRO A HA   1 
ATOM   2841 H HB2  . PRO A 1 187 ? 42.36913 12.60229  20.43003 1.000 28.19738  ? 184 PRO A HB2  1 
ATOM   2842 H HB3  . PRO A 1 187 ? 42.93343 14.04770  20.77320 1.000 28.19738  ? 184 PRO A HB3  1 
ATOM   2843 H HG2  . PRO A 1 187 ? 42.63916 13.33605  18.35036 1.000 30.33351  ? 184 PRO A HG2  1 
ATOM   2844 H HG3  . PRO A 1 187 ? 43.82803 14.30702  18.76172 1.000 30.33351  ? 184 PRO A HG3  1 
ATOM   2845 H HD2  . PRO A 1 187 ? 43.99476 11.54815  18.23181 1.000 31.32785  ? 184 PRO A HD2  1 
ATOM   2846 H HD3  . PRO A 1 187 ? 45.03185 12.67321  17.80276 1.000 31.32785  ? 184 PRO A HD3  1 
ATOM   2847 N N    . LEU A 1 188 ? 44.31757 10.16353  21.51824 1.000 22.38782  ? 185 LEU A N    1 
ATOM   2848 C CA   . LEU A 1 188 ? 43.93175 9.04287   22.36801 1.000 22.91405  ? 185 LEU A CA   1 
ATOM   2849 C C    . LEU A 1 188 ? 44.85871 8.85530   23.56069 1.000 22.71887  ? 185 LEU A C    1 
ATOM   2850 O O    . LEU A 1 188 ? 44.47992 8.18868   24.53002 1.000 22.70496  ? 185 LEU A O    1 
ATOM   2851 C CB   . LEU A 1 188 ? 43.89789 7.75422   21.54667 1.000 22.65166  ? 185 LEU A CB   1 
ATOM   2852 C CG   . LEU A 1 188 ? 42.93272 7.74693   20.36034 1.000 22.90185  ? 185 LEU A CG   1 
ATOM   2853 C CD1  . LEU A 1 188 ? 43.06371 6.44960   19.57092 1.000 24.45639  ? 185 LEU A CD1  1 
ATOM   2854 C CD2  . LEU A 1 188 ? 41.49867 7.92653   20.84028 1.000 26.15941  ? 185 LEU A CD2  1 
ATOM   2855 H H    . LEU A 1 188 ? 44.74140 9.94466   20.80266 1.000 26.88436  ? 185 LEU A H    1 
ATOM   2856 H HA   . LEU A 1 188 ? 43.03982 9.21048   22.71043 1.000 27.51585  ? 185 LEU A HA   1 
ATOM   2857 H HB2  . LEU A 1 188 ? 44.78784 7.59518   21.19510 1.000 27.20098  ? 185 LEU A HB2  1 
ATOM   2858 H HB3  . LEU A 1 188 ? 43.63830 7.02707   22.13383 1.000 27.20098  ? 185 LEU A HB3  1 
ATOM   2859 H HG   . LEU A 1 188 ? 43.15395 8.48532   19.77149 1.000 27.50120  ? 185 LEU A HG   1 
ATOM   2860 H HD11 . LEU A 1 188 ? 42.45910 6.47871   18.81297 1.000 29.36665  ? 185 LEU A HD11 1 
ATOM   2861 H HD12 . LEU A 1 188 ? 43.97847 6.35946   19.26108 1.000 29.36665  ? 185 LEU A HD12 1 
ATOM   2862 H HD13 . LEU A 1 188 ? 42.83500 5.70428   20.14806 1.000 29.36665  ? 185 LEU A HD13 1 
ATOM   2863 H HD21 . LEU A 1 188 ? 40.89810 7.82702   20.08508 1.000 31.41027  ? 185 LEU A HD21 1 
ATOM   2864 H HD22 . LEU A 1 188 ? 41.30291 7.25235   21.50965 1.000 31.41027  ? 185 LEU A HD22 1 
ATOM   2865 H HD23 . LEU A 1 188 ? 41.40285 8.81194   21.22468 1.000 31.41027  ? 185 LEU A HD23 1 
ATOM   2866 N N    . VAL A 1 189 ? 46.05523 9.42446   23.51006 1.000 23.75412  ? 186 VAL A N    1 
ATOM   2867 C CA   . VAL A 1 189 ? 47.05046 9.25633   24.55935 1.000 24.24090  ? 186 VAL A CA   1 
ATOM   2868 C C    . VAL A 1 189 ? 47.40918 7.78396   24.69657 1.000 26.14686  ? 186 VAL A C    1 
ATOM   2869 O O    . VAL A 1 189 ? 47.41310 7.23382   25.80242 1.000 25.24228  ? 186 VAL A O    1 
ATOM   2870 C CB   . VAL A 1 189 ? 46.57137 9.83839   25.90220 1.000 23.83961  ? 186 VAL A CB   1 
ATOM   2871 C CG1  . VAL A 1 189 ? 47.76206 10.00881  26.85263 1.000 29.00986  ? 186 VAL A CG1  1 
ATOM   2872 C CG2  . VAL A 1 189 ? 45.86695 11.16037  25.69032 1.000 24.11569  ? 186 VAL A CG2  1 
ATOM   2873 H H    . VAL A 1 189 ? 46.32132 9.92471   22.86311 1.000 28.52392  ? 186 VAL A H    1 
ATOM   2874 H HA   . VAL A 1 189 ? 47.85090 9.73701   24.29642 1.000 29.10807  ? 186 VAL A HA   1 
ATOM   2875 H HB   . VAL A 1 189 ? 45.93779 9.22495   26.30614 1.000 28.62651  ? 186 VAL A HB   1 
ATOM   2876 H HG11 . VAL A 1 189 ? 47.46586 10.47630  27.64925 1.000 34.83082  ? 186 VAL A HG11 1 
ATOM   2877 H HG12 . VAL A 1 189 ? 48.10378 9.13284   27.09097 1.000 34.83082  ? 186 VAL A HG12 1 
ATOM   2878 H HG13 . VAL A 1 189 ? 48.45239 10.52261  26.40502 1.000 34.83082  ? 186 VAL A HG13 1 
ATOM   2879 H HG21 . VAL A 1 189 ? 45.71957 11.58129  26.55171 1.000 28.95781  ? 186 VAL A HG21 1 
ATOM   2880 H HG22 . VAL A 1 189 ? 46.42299 11.72906  25.13507 1.000 28.95781  ? 186 VAL A HG22 1 
ATOM   2881 H HG23 . VAL A 1 189 ? 45.01715 10.99861  25.25149 1.000 28.95781  ? 186 VAL A HG23 1 
ATOM   2882 N N    . LEU A 1 190 ? 47.72332 7.14138   23.57493 1.000 27.29137  ? 187 LEU A N    1 
ATOM   2883 C CA   . LEU A 1 190 ? 48.27741 5.79572   23.59689 1.000 33.56040  ? 187 LEU A CA   1 
ATOM   2884 C C    . LEU A 1 190 ? 49.76734 5.84580   23.91889 1.000 37.76738  ? 187 LEU A C    1 
ATOM   2885 O O    . LEU A 1 190 ? 50.44282 6.84704   23.66718 1.000 39.45177  ? 187 LEU A O    1 
ATOM   2886 C CB   . LEU A 1 190 ? 48.05450 5.10864   22.25399 1.000 32.76213  ? 187 LEU A CB   1 
ATOM   2887 C CG   . LEU A 1 190 ? 46.60363 4.72590   21.95685 1.000 29.63443  ? 187 LEU A CG   1 
ATOM   2888 C CD1  . LEU A 1 190 ? 46.43068 4.32495   20.51542 1.000 33.37130  ? 187 LEU A CD1  1 
ATOM   2889 C CD2  . LEU A 1 190 ? 46.17808 3.58914   22.89114 1.000 31.60847  ? 187 LEU A CD2  1 
ATOM   2890 H H    . LEU A 1 190 ? 47.62384 7.46639   22.78495 1.000 32.76863  ? 187 LEU A H    1 
ATOM   2891 H HA   . LEU A 1 190 ? 47.83520 5.26766   24.27991 1.000 40.29146  ? 187 LEU A HA   1 
ATOM   2892 H HB2  . LEU A 1 190 ? 48.34765 5.70868   21.55048 1.000 39.33354  ? 187 LEU A HB2  1 
ATOM   2893 H HB3  . LEU A 1 190 ? 48.58054 4.29387   22.23568 1.000 39.33354  ? 187 LEU A HB3  1 
ATOM   2894 H HG   . LEU A 1 190 ? 46.02969 5.49275   22.10996 1.000 35.58030  ? 187 LEU A HG   1 
ATOM   2895 H HD11 . LEU A 1 190 ? 45.51539 4.03577   20.37570 1.000 40.06454  ? 187 LEU A HD11 1 
ATOM   2896 H HD12 . LEU A 1 190 ? 46.62646 5.08816   19.94966 1.000 40.06454  ? 187 LEU A HD12 1 
ATOM   2897 H HD13 . LEU A 1 190 ? 47.04140 3.59871   20.31418 1.000 40.06454  ? 187 LEU A HD13 1 
ATOM   2898 H HD21 . LEU A 1 190 ? 45.29614 3.28010   22.63117 1.000 37.94914  ? 187 LEU A HD21 1 
ATOM   2899 H HD22 . LEU A 1 190 ? 46.81777 2.86369   22.81758 1.000 37.94914  ? 187 LEU A HD22 1 
ATOM   2900 H HD23 . LEU A 1 190 ? 46.15711 3.92053   23.80253 1.000 37.94914  ? 187 LEU A HD23 1 
ATOM   2901 N N    . LYS A 1 191 ? 50.27821 4.75048   24.48801 1.000 44.54548  ? 188 LYS A N    1 
ATOM   2902 C CA   A LYS A 1 191 ? 51.68897 4.69479   24.86138 0.426 55.16151  ? 188 LYS A CA   1 
ATOM   2903 C CA   B LYS A 1 191 ? 51.68857 4.70410   24.86167 0.574 55.17717  ? 188 LYS A CA   1 
ATOM   2904 C C    . LYS A 1 191 ? 52.57039 4.58755   23.62339 1.000 60.40521  ? 188 LYS A C    1 
ATOM   2905 O O    . LYS A 1 191 ? 53.44897 5.42857   23.38998 1.000 69.66651  ? 188 LYS A O    1 
ATOM   2906 C CB   A LYS A 1 191 ? 51.93677 3.51152   25.80356 0.426 56.12991  ? 188 LYS A CB   1 
ATOM   2907 C CB   B LYS A 1 191 ? 51.94577 3.54443   25.83258 0.574 56.04730  ? 188 LYS A CB   1 
ATOM   2908 C CG   A LYS A 1 191 ? 53.34812 3.43964   26.37278 0.426 60.85898  ? 188 LYS A CG   1 
ATOM   2909 C CG   B LYS A 1 191 ? 53.33700 3.57007   26.45478 0.574 60.85782  ? 188 LYS A CG   1 
ATOM   2910 C CD   A LYS A 1 191 ? 53.47407 4.24481   27.66209 0.426 60.92272  ? 188 LYS A CD   1 
ATOM   2911 C CD   B LYS A 1 191 ? 53.34982 3.00782   27.87094 0.574 62.19725  ? 188 LYS A CD   1 
ATOM   2912 C CE   A LYS A 1 191 ? 54.93254 4.42594   28.06820 0.426 62.14266  ? 188 LYS A CE   1 
ATOM   2913 C CE   B LYS A 1 191 ? 53.84926 1.57026   27.90597 0.574 74.54150  ? 188 LYS A CE   1 
ATOM   2914 N NZ   A LYS A 1 191 ? 55.08062 5.37978   29.20832 0.426 53.62455  ? 188 LYS A NZ   1 
ATOM   2915 N NZ   B LYS A 1 191 ? 54.66746 1.30987   29.13006 0.574 72.98979  ? 188 LYS A NZ   1 
ATOM   2916 H H    A LYS A 1 191 ? 49.83339 4.03621   24.66564 0.426 53.47356  ? 188 LYS A H    1 
ATOM   2917 H H    B LYS A 1 191 ? 49.83551 4.03461   24.66449 0.574 53.47356  ? 188 LYS A H    1 
ATOM   2918 H HA   A LYS A 1 191 ? 51.92171 5.50924   25.33404 0.426 66.21280  ? 188 LYS A HA   1 
ATOM   2919 H HA   B LYS A 1 191 ? 51.91875 5.52621   25.32215 0.574 66.23158  ? 188 LYS A HA   1 
ATOM   2920 H HB2  A LYS A 1 191 ? 51.32266 3.57861   26.55140 0.426 67.37487  ? 188 LYS A HB2  1 
ATOM   2921 H HB2  B LYS A 1 191 ? 51.29728 3.58954   26.55253 0.574 67.27574  ? 188 LYS A HB2  1 
ATOM   2922 H HB3  A LYS A 1 191 ? 51.77601 2.68909   25.31502 0.426 67.37487  ? 188 LYS A HB3  1 
ATOM   2923 H HB3  B LYS A 1 191 ? 51.85039 2.70720   25.35213 0.574 67.27574  ? 188 LYS A HB3  1 
ATOM   2924 H HG2  A LYS A 1 191 ? 53.56895 2.51550   26.56797 0.426 73.04976  ? 188 LYS A HG2  1 
ATOM   2925 H HG2  B LYS A 1 191 ? 53.93755 3.03478   25.91284 0.574 73.04836  ? 188 LYS A HG2  1 
ATOM   2926 H HG3  A LYS A 1 191 ? 53.97408 3.80078   25.72575 0.426 73.04976  ? 188 LYS A HG3  1 
ATOM   2927 H HG3  B LYS A 1 191 ? 53.65180 4.48682   26.49194 0.574 73.04836  ? 188 LYS A HG3  1 
ATOM   2928 H HD2  A LYS A 1 191 ? 53.08262 5.12274   27.53208 0.426 73.12625  ? 188 LYS A HD2  1 
ATOM   2929 H HD2  B LYS A 1 191 ? 53.93734 3.54652   28.42367 0.574 74.65568  ? 188 LYS A HD2  1 
ATOM   2930 H HD3  A LYS A 1 191 ? 53.01398 3.77911   28.37788 0.426 73.12625  ? 188 LYS A HD3  1 
ATOM   2931 H HD3  B LYS A 1 191 ? 52.44886 3.02468   28.22995 0.574 74.65568  ? 188 LYS A HD3  1 
ATOM   2932 H HE2  A LYS A 1 191 ? 55.29702 3.56924   28.34045 0.426 74.59018  ? 188 LYS A HE2  1 
ATOM   2933 H HE2  B LYS A 1 191 ? 53.09060 0.96585   27.91074 0.574 89.46878  ? 188 LYS A HE2  1 
ATOM   2934 H HE3  A LYS A 1 191 ? 55.43306 4.77488   27.31413 0.426 74.59018  ? 188 LYS A HE3  1 
ATOM   2935 H HE3  B LYS A 1 191 ? 54.40223 1.40243   27.12689 0.574 89.46878  ? 188 LYS A HE3  1 
ATOM   2936 H HZ1  A LYS A 1 191 ? 55.94154 5.48305   29.40894 0.426 64.36844  ? 188 LYS A HZ1  1 
ATOM   2937 H HZ1  B LYS A 1 191 ? 54.93154 0.46008   29.14460 0.574 87.60674  ? 188 LYS A HZ1  1 
ATOM   2938 H HZ2  A LYS A 1 191 ? 54.73809 6.17149   28.98930 0.426 64.36844  ? 188 LYS A HZ2  1 
ATOM   2939 H HZ2  B LYS A 1 191 ? 55.38559 1.83559   29.13370 0.574 87.60674  ? 188 LYS A HZ2  1 
ATOM   2940 H HZ3  A LYS A 1 191 ? 54.65275 5.06787   29.92368 0.426 64.36844  ? 188 LYS A HZ3  1 
ATOM   2941 H HZ3  B LYS A 1 191 ? 54.18497 1.47492   29.85949 0.574 87.60674  ? 188 LYS A HZ3  1 
ATOM   2942 N N    . ASP A 1 192 ? 52.34343 3.55721   22.81205 1.000 61.46715  ? 189 ASP A N    1 
ATOM   2943 C CA   . ASP A 1 192 ? 53.13498 3.34721   21.60173 1.000 94.02446  ? 189 ASP A CA   1 
ATOM   2944 C C    . ASP A 1 192 ? 52.23660 3.17833   20.38327 1.000 86.96784  ? 189 ASP A C    1 
ATOM   2945 O O    . ASP A 1 192 ? 52.07003 4.10651   19.59545 1.000 76.84911  ? 189 ASP A O    1 
ATOM   2946 C CB   . ASP A 1 192 ? 54.04392 2.12226   21.75455 1.000 81.60488  ? 189 ASP A CB   1 
ATOM   2947 C CG   . ASP A 1 192 ? 55.13862 2.33419   22.78386 1.000 97.04098  ? 189 ASP A CG   1 
ATOM   2948 O OD1  . ASP A 1 192 ? 55.68267 3.45995   22.85187 1.000 93.27369  ? 189 ASP A OD1  1 
ATOM   2949 O OD2  . ASP A 1 192 ? 55.45162 1.37812   23.52687 1.000 105.27215 ? 189 ASP A OD2  1 
ATOM   2950 H H    . ASP A 1 192 ? 51.73476 2.96339   22.94050 1.000 73.77956  ? 189 ASP A H    1 
ATOM   2951 H HA   . ASP A 1 192 ? 53.69832 4.12369   21.45809 1.000 112.84834 ? 189 ASP A HA   1 
ATOM   2952 H HB2  . ASP A 1 192 ? 53.50884 1.36387   22.03639 1.000 97.94484  ? 189 ASP A HB2  1 
ATOM   2953 H HB3  . ASP A 1 192 ? 54.46555 1.93224   20.90189 1.000 97.94484  ? 189 ASP A HB3  1 
HETATM 2954 O O    . HOH B 2 .   ? 23.74385 -19.70889 18.52155 1.000 52.29610  ? 201 HOH A O    1 
HETATM 2955 O O    . HOH B 2 .   ? 49.95921 -18.07928 21.56888 1.000 36.41851  ? 202 HOH A O    1 
HETATM 2956 O O    . HOH B 2 .   ? 45.83383 -1.86241  21.63599 1.000 28.76608  ? 203 HOH A O    1 
HETATM 2957 O O    . HOH B 2 .   ? 21.57588 -15.47255 12.55906 1.000 46.57232  ? 204 HOH A O    1 
HETATM 2958 O O    . HOH B 2 .   ? 29.95815 -6.14419  2.59690  1.000 40.78621  ? 205 HOH A O    1 
HETATM 2959 O O    . HOH B 2 .   ? 49.08800 -24.18951 8.58225  1.000 24.95362  ? 206 HOH A O    1 
HETATM 2960 O O    . HOH B 2 .   ? 50.70049 -3.85224  17.21350 1.000 41.72663  ? 207 HOH A O    1 
HETATM 2961 O O    . HOH B 2 .   ? 17.62241 -7.38125  25.21565 1.000 56.49944  ? 208 HOH A O    1 
HETATM 2962 O O    . HOH B 2 .   ? 37.71386 -3.21918  1.71153  1.000 34.24098  ? 209 HOH A O    1 
HETATM 2963 O O    . HOH B 2 .   ? 16.85776 -2.53157  12.11964 1.000 40.95563  ? 210 HOH A O    1 
HETATM 2964 O O    . HOH B 2 .   ? 51.16467 9.26092   24.49443 1.000 53.47294  ? 211 HOH A O    1 
HETATM 2965 O O    . HOH B 2 .   ? 46.257   -28.220   14.327   1.000 27.03465  ? 212 HOH A O    1 
HETATM 2966 O O    A HOH B 2 .   ? 49.86289 -10.89065 2.75096  0.994 60.31916  ? 213 HOH A O    1 
HETATM 2967 O O    . HOH B 2 .   ? 25.38558 1.44400   20.14021 1.000 26.82020  ? 214 HOH A O    1 
HETATM 2968 O O    . HOH B 2 .   ? 43.74088 -13.41696 2.88837  1.000 48.98737  ? 215 HOH A O    1 
HETATM 2969 O O    . HOH B 2 .   ? 35.08161 -25.40024 9.05248  1.000 36.61421  ? 216 HOH A O    1 
HETATM 2970 O O    . HOH B 2 .   ? 48.35389 0.11865   11.72609 1.000 61.87930  ? 217 HOH A O    1 
HETATM 2971 O O    . HOH B 2 .   ? 13.12569 0.68446   17.42519 1.000 83.67469  ? 218 HOH A O    1 
HETATM 2972 O O    . HOH B 2 .   ? 38.59375 -27.92483 11.04975 1.000 41.03549  ? 219 HOH A O    1 
HETATM 2973 O O    . HOH B 2 .   ? 52.20083 -7.40029  12.50938 1.000 55.73969  ? 220 HOH A O    1 
HETATM 2974 O O    . HOH B 2 .   ? 54.52103 -12.75655 7.50950  1.000 57.83028  ? 221 HOH A O    1 
HETATM 2975 O O    . HOH B 2 .   ? 31.72026 -14.45660 26.16679 1.000 23.26028  ? 222 HOH A O    1 
HETATM 2976 O O    . HOH B 2 .   ? 47.34120 -25.25418 18.31811 1.000 33.16505  ? 223 HOH A O    1 
HETATM 2977 O O    . HOH B 2 .   ? 22.65420 -18.82209 21.09373 1.000 79.15522  ? 224 HOH A O    1 
HETATM 2978 O O    . HOH B 2 .   ? 23.80657 -17.84843 16.26671 1.000 42.82591  ? 225 HOH A O    1 
HETATM 2979 O O    . HOH B 2 .   ? 33.68906 -19.99650 18.11112 1.000 33.26088  ? 226 HOH A O    1 
HETATM 2980 O O    . HOH B 2 .   ? 26.05516 2.98864   17.83478 1.000 24.22404  ? 227 HOH A O    1 
HETATM 2981 O O    . HOH B 2 .   ? 41.59119 -18.47349 0.80661  1.000 40.09407  ? 228 HOH A O    1 
HETATM 2982 O O    . HOH B 2 .   ? 39.09760 -29.74574 8.85462  1.000 45.17589  ? 229 HOH A O    1 
HETATM 2983 O O    . HOH B 2 .   ? 39.04372 -18.64276 23.74117 1.000 48.25224  ? 230 HOH A O    1 
HETATM 2984 O O    . HOH B 2 .   ? 45.67788 14.71853  15.56568 1.000 29.44455  ? 231 HOH A O    1 
HETATM 2985 O O    . HOH B 2 .   ? 45.60068 8.91057   5.09833  1.000 36.09761  ? 232 HOH A O    1 
HETATM 2986 O O    . HOH B 2 .   ? 50.95260 -11.62002 7.11099  1.000 41.07307  ? 233 HOH A O    1 
HETATM 2987 O O    . HOH B 2 .   ? 41.41627 -23.14516 21.82386 1.000 30.80728  ? 234 HOH A O    1 
HETATM 2988 O O    . HOH B 2 .   ? 43.85936 -27.94795 17.22549 1.000 36.57607  ? 235 HOH A O    1 
HETATM 2989 O O    . HOH B 2 .   ? 27.62858 1.82122   7.82389  1.000 34.51768  ? 236 HOH A O    1 
HETATM 2990 O O    . HOH B 2 .   ? 45.21803 -12.22882 9.77742  1.000 21.78267  ? 237 HOH A O    1 
HETATM 2991 O O    . HOH B 2 .   ? 38.87446 -17.60274 26.77423 1.000 45.52313  ? 238 HOH A O    1 
HETATM 2992 O O    . HOH B 2 .   ? 19.93326 -7.84753  19.42688 1.000 33.90172  ? 239 HOH A O    1 
HETATM 2993 O O    . HOH B 2 .   ? 31.64458 -11.79263 19.25103 1.000 23.18374  ? 240 HOH A O    1 
HETATM 2994 O O    . HOH B 2 .   ? 34.57818 2.54947   -0.71449 1.000 52.27162  ? 241 HOH A O    1 
HETATM 2995 O O    . HOH B 2 .   ? 50.00874 9.84326   15.89995 1.000 38.55103  ? 242 HOH A O    1 
HETATM 2996 O O    . HOH B 2 .   ? 21.66886 -19.55392 11.59568 1.000 44.23320  ? 243 HOH A O    1 
HETATM 2997 O O    . HOH B 2 .   ? 31.94585 10.33428  13.10877 1.000 27.80925  ? 244 HOH A O    1 
HETATM 2998 O O    . HOH B 2 .   ? 42.36938 -24.76030 10.98776 1.000 19.41241  ? 245 HOH A O    1 
HETATM 2999 O O    . HOH B 2 .   ? 46.260   -29.989   7.457    1.000 21.64380  ? 246 HOH A O    1 
HETATM 3000 O O    . HOH B 2 .   ? 34.76028 -22.27206 15.14433 1.000 41.36413  ? 247 HOH A O    1 
HETATM 3001 O O    . HOH B 2 .   ? 23.95357 0.29971   7.45975  1.000 47.24097  ? 248 HOH A O    1 
HETATM 3002 O O    . HOH B 2 .   ? 54.46067 -15.33454 15.21642 1.000 36.99426  ? 249 HOH A O    1 
HETATM 3003 O O    . HOH B 2 .   ? 14.65769 -5.99718  11.21003 1.000 58.06752  ? 250 HOH A O    1 
HETATM 3004 O O    . HOH B 2 .   ? 48.33008 8.77806   21.30575 1.000 28.53853  ? 251 HOH A O    1 
HETATM 3005 O O    . HOH B 2 .   ? 42.92086 -26.08971 3.69080  1.000 34.99295  ? 252 HOH A O    1 
HETATM 3006 O O    . HOH B 2 .   ? 29.51444 -10.07828 18.43108 1.000 22.64462  ? 253 HOH A O    1 
HETATM 3007 O O    . HOH B 2 .   ? 46.32418 -2.02269  8.03000  1.000 36.37602  ? 254 HOH A O    1 
HETATM 3008 O O    . HOH B 2 .   ? 38.37028 -20.62886 2.56778  1.000 31.38251  ? 255 HOH A O    1 
HETATM 3009 O O    . HOH B 2 .   ? 30.45529 8.20905   11.35906 1.000 43.98487  ? 256 HOH A O    1 
HETATM 3010 O O    . HOH B 2 .   ? 22.36390 2.75239   18.69610 1.000 39.88751  ? 257 HOH A O    1 
HETATM 3011 O O    . HOH B 2 .   ? 53.46051 -10.65153 20.48348 1.000 56.08438  ? 258 HOH A O    1 
HETATM 3012 O O    . HOH B 2 .   ? 37.66675 -25.88599 15.93709 1.000 36.57723  ? 259 HOH A O    1 
HETATM 3013 O O    . HOH B 2 .   ? 19.28234 3.50964   14.56012 1.000 58.21242  ? 260 HOH A O    1 
HETATM 3014 O O    . HOH B 2 .   ? 55.66297 -12.84215 15.80320 1.000 59.61992  ? 261 HOH A O    1 
HETATM 3015 O O    . HOH B 2 .   ? 47.83034 -0.56662  14.28919 1.000 35.31378  ? 262 HOH A O    1 
HETATM 3016 O O    . HOH B 2 .   ? 44.34702 -30.11148 13.91169 1.000 29.80406  ? 263 HOH A O    1 
HETATM 3017 O O    . HOH B 2 .   ? 21.20019 -9.91522  25.02972 1.000 36.38590  ? 264 HOH A O    1 
HETATM 3018 O O    . HOH B 2 .   ? 30.64785 -23.53002 6.42150  1.000 53.12110  ? 265 HOH A O    1 
HETATM 3019 O O    . HOH B 2 .   ? 38.81474 -18.96789 0.45071  1.000 43.73542  ? 266 HOH A O    1 
HETATM 3020 O O    . HOH B 2 .   ? 45.93085 -1.25110  24.75216 1.000 48.74938  ? 267 HOH A O    1 
HETATM 3021 O O    . HOH B 2 .   ? 34.24664 -19.48159 20.97473 1.000 41.92346  ? 268 HOH A O    1 
HETATM 3022 O O    . HOH B 2 .   ? 46.46087 1.93839   3.26987  1.000 53.06656  ? 269 HOH A O    1 
HETATM 3023 O O    B HOH B 2 .   ? 22.540   -15.245   30.145   1.000 68.45132  ? 270 HOH A O    1 
HETATM 3024 O O    . HOH B 2 .   ? 14.70121 -6.60848  15.19592 1.000 58.16421  ? 271 HOH A O    1 
HETATM 3025 O O    . HOH B 2 .   ? 48.29426 -20.59211 22.88755 1.000 40.50658  ? 272 HOH A O    1 
HETATM 3026 O O    . HOH B 2 .   ? 28.77764 6.05362   12.17452 1.000 25.71344  ? 273 HOH A O    1 
HETATM 3027 O O    . HOH B 2 .   ? 44.76172 -24.10961 3.97813  1.000 24.77949  ? 274 HOH A O    1 
HETATM 3028 O O    . HOH B 2 .   ? 20.14185 -13.19987 12.05399 1.000 54.19460  ? 275 HOH A O    1 
HETATM 3029 O O    . HOH B 2 .   ? 23.19165 -6.30901  32.38433 1.000 42.95613  ? 276 HOH A O    1 
HETATM 3030 O O    . HOH B 2 .   ? 30.41462 -5.41456  -4.58398 1.000 62.72846  ? 277 HOH A O    1 
HETATM 3031 O O    . HOH B 2 .   ? 22.08818 -9.73740  18.88189 1.000 31.70318  ? 278 HOH A O    1 
HETATM 3032 O O    . HOH B 2 .   ? 28.15561 -23.08574 11.05887 1.000 45.43628  ? 279 HOH A O    1 
HETATM 3033 O O    . HOH B 2 .   ? 51.09399 -11.44292 21.68395 1.000 37.72912  ? 280 HOH A O    1 
HETATM 3034 O O    . HOH B 2 .   ? 24.90626 3.92757   11.97868 1.000 45.41581  ? 281 HOH A O    1 
HETATM 3035 O O    . HOH B 2 .   ? 26.52667 -12.19695 30.74085 1.000 42.93510  ? 282 HOH A O    1 
HETATM 3036 O O    . HOH B 2 .   ? 36.43403 -27.60651 6.36976  1.000 56.27940  ? 283 HOH A O    1 
HETATM 3037 O O    . HOH B 2 .   ? 40.54032 -15.44898 0.86248  1.000 51.11708  ? 284 HOH A O    1 
HETATM 3038 O O    . HOH B 2 .   ? 28.82289 -8.70197  2.93338  1.000 41.85724  ? 285 HOH A O    1 
HETATM 3039 O O    . HOH B 2 .   ? 26.79179 -15.04991 0.14659  1.000 47.29923  ? 286 HOH A O    1 
HETATM 3040 O O    . HOH B 2 .   ? 49.92532 -17.49946 4.27893  1.000 53.81541  ? 287 HOH A O    1 
HETATM 3041 O O    . HOH B 2 .   ? 51.54056 -6.40379  15.50296 1.000 41.13586  ? 288 HOH A O    1 
HETATM 3042 O O    . HOH B 2 .   ? 52.00017 -9.17667  22.99325 1.000 47.74594  ? 289 HOH A O    1 
HETATM 3043 O O    . HOH B 2 .   ? 18.94175 -9.73010  12.67249 1.000 36.61146  ? 290 HOH A O    1 
HETATM 3044 O O    . HOH B 2 .   ? 22.63912 -12.36738 19.85747 1.000 33.83085  ? 291 HOH A O    1 
HETATM 3045 O O    . HOH B 2 .   ? 49.82690 5.73204   11.21090 1.000 52.50098  ? 292 HOH A O    1 
HETATM 3046 O O    . HOH B 2 .   ? 44.41850 -22.69742 22.70521 1.000 32.99974  ? 293 HOH A O    1 
HETATM 3047 O O    . HOH B 2 .   ? 37.71836 12.22393  23.95661 1.000 36.10684  ? 294 HOH A O    1 
HETATM 3048 O O    . HOH B 2 .   ? 26.07079 -12.32484 27.85466 1.000 36.14142  ? 295 HOH A O    1 
HETATM 3049 O O    . HOH B 2 .   ? 53.483   -20.703   12.190   1.000 48.44966  ? 296 HOH A O    1 
HETATM 3050 O O    . HOH B 2 .   ? 53.49516 -7.90365  17.40748 1.000 33.20221  ? 297 HOH A O    1 
HETATM 3051 O O    . HOH B 2 .   ? 26.39852 -19.34007 22.61161 1.000 49.54516  ? 298 HOH A O    1 
HETATM 3052 O O    . HOH B 2 .   ? 42.98487 -23.32470 25.22550 1.000 62.96244  ? 299 HOH A O    1 
HETATM 3053 O O    . HOH B 2 .   ? 48.350   2.562     25.544   1.000 42.82651  ? 300 HOH A O    1 
HETATM 3054 O O    . HOH B 2 .   ? 35.56598 7.50017   5.30927  1.000 43.97655  ? 301 HOH A O    1 
HETATM 3055 O O    . HOH B 2 .   ? 41.24410 1.75407   0.96577  1.000 56.73570  ? 302 HOH A O    1 
HETATM 3056 O O    . HOH B 2 .   ? 36.80309 -19.44387 21.71082 1.000 52.82521  ? 303 HOH A O    1 
HETATM 3057 O O    A HOH B 2 .   ? 17.09186 0.71092   12.88065 1.000 59.42341  ? 304 HOH A O    1 
HETATM 3058 O O    . HOH B 2 .   ? 24.44048 -22.16779 10.30287 1.000 59.88651  ? 305 HOH A O    1 
HETATM 3059 O O    . HOH B 2 .   ? 24.03461 -19.08431 4.47900  1.000 49.17707  ? 306 HOH A O    1 
HETATM 3060 O O    . HOH B 2 .   ? 40.16368 12.56235  22.62590 1.000 38.48251  ? 307 HOH A O    1 
HETATM 3061 O O    . HOH B 2 .   ? 38.729   11.656    8.251    1.000 37.11421  ? 308 HOH A O    1 
HETATM 3062 O O    . HOH B 2 .   ? 25.08562 -16.36726 24.49328 1.000 47.55854  ? 309 HOH A O    1 
HETATM 3063 O O    . HOH B 2 .   ? 18.94598 -9.12321  21.83076 1.000 47.88316  ? 310 HOH A O    1 
HETATM 3064 O O    . HOH B 2 .   ? 49.72545 10.86316  22.45746 1.000 52.91156  ? 311 HOH A O    1 
HETATM 3065 O O    . HOH B 2 .   ? 11.58300 -6.83485  19.46019 1.000 61.93317  ? 312 HOH A O    1 
HETATM 3066 O O    . HOH B 2 .   ? 49.91491 3.28710   15.02122 1.000 49.79551  ? 313 HOH A O    1 
HETATM 3067 O O    . HOH B 2 .   ? 35.073   -14.078   26.836   1.000 29.08963  ? 314 HOH A O    1 
HETATM 3068 O O    . HOH B 2 .   ? 48.28245 8.61308   3.97843  1.000 47.63242  ? 315 HOH A O    1 
HETATM 3069 O O    . HOH B 2 .   ? 19.90840 2.69436   18.93306 1.000 53.90256  ? 316 HOH A O    1 
HETATM 3070 O O    . HOH B 2 .   ? 47.63021 0.19723   22.20818 1.000 51.70257  ? 317 HOH A O    1 
HETATM 3071 O O    . HOH B 2 .   ? 40.67258 -28.41981 18.36796 1.000 52.76709  ? 318 HOH A O    1 
HETATM 3072 O O    . HOH B 2 .   ? 44.52513 3.02030   1.76483  1.000 62.25693  ? 319 HOH A O    1 
HETATM 3073 O O    . HOH B 2 .   ? 54.33004 -18.69221 15.32022 1.000 61.17856  ? 320 HOH A O    1 
HETATM 3074 O O    . HOH B 2 .   ? 14.62914 -8.08591  12.67453 1.000 71.34938  ? 321 HOH A O    1 
HETATM 3075 O O    . HOH B 2 .   ? 47.36978 -28.81114 19.60537 1.000 59.67653  ? 322 HOH A O    1 
HETATM 3076 O O    . HOH B 2 .   ? 38.86719 -20.57569 26.57748 1.000 45.04775  ? 323 HOH A O    1 
HETATM 3077 O O    B HOH B 2 .   ? 17.29170 -0.31832  10.89080 0.999 68.87048  ? 324 HOH A O    1 
HETATM 3078 O O    . HOH B 2 .   ? 38.11080 -27.64611 17.97896 1.000 53.51856  ? 325 HOH A O    1 
HETATM 3079 O O    . HOH B 2 .   ? 26.27587 6.22244   11.70660 1.000 53.53553  ? 326 HOH A O    1 
HETATM 3080 O O    . HOH B 2 .   ? 22.00514 -17.33293 14.66251 1.000 63.05480  ? 327 HOH A O    1 
HETATM 3081 O O    . HOH B 2 .   ? 13.43406 -4.36409  24.50540 1.000 72.62643  ? 328 HOH A O    1 
HETATM 3082 O O    . HOH B 2 .   ? 51.43822 7.64454   14.67156 1.000 49.78393  ? 329 HOH A O    1 
HETATM 3083 O O    . HOH B 2 .   ? 22.16320 -15.22230 18.46515 1.000 51.61763  ? 330 HOH A O    1 
HETATM 3084 O O    . HOH B 2 .   ? 48.70042 1.43264   16.56439 1.000 48.35978  ? 331 HOH A O    1 
HETATM 3085 O O    . HOH B 2 .   ? 50.58621 9.37207   18.96018 1.000 53.35050  ? 332 HOH A O    1 
HETATM 3086 O O    . HOH B 2 .   ? 20.68254 -10.95110 22.13485 1.000 51.28131  ? 333 HOH A O    1 
HETATM 3087 O O    . HOH B 2 .   ? 44.95494 -8.83359  -1.44032 1.000 61.87115  ? 334 HOH A O    1 
HETATM 3088 O O    . HOH B 2 .   ? 35.91442 -26.91757 11.58319 1.000 59.77644  ? 335 HOH A O    1 
HETATM 3089 O O    . HOH B 2 .   ? 14.16419 -2.58148  25.84409 1.000 64.17427  ? 336 HOH A O    1 
# 
