data_9CFM
# 
_entry.id   9CFM 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9CFM         pdb_00009cfm 10.2210/pdb9cfm/pdb 
WWPDB D_1000285421 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-03-12 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_database_PDB_caveat.id     1 
_database_PDB_caveat.text   'Several atoms in ILE A 21, PRO A 22, VAL A 23, and ILE A 105 have B-factors less than 0.0001.' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9CFM 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-27 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB 'DJ-1 no mixing'                       9CEI unspecified 
PDB 'DJ-1 3 sec mixing with methylglyoxal' 9CFI unspecified 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              mwilson13@unl.edu 
_pdbx_contact_author.name_first         Mark 
_pdbx_contact_author.name_last          Wilson 
_pdbx_contact_author.name_mi            A 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6317-900X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Zielinski, K.A.'  1  ? 
'Dolamore, C.'     2  ? 
'Dalton, K.'       3  ? 
'Meisburger, S.P.' 4  ? 
'Smith, N.'        5  ? 
'Termini, J.'      6  ? 
'Henning, R.'      7  ? 
'Srajer, V.'       8  ? 
'Hekstra, D.'      9  ? 
'Pollack, L.'      10 ? 
'Wilson, M.A.'     11 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Biorxiv 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2692-8205 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Resolving DJ-1 Glyoxalase Catalysis Using Mix-and-Inject Serial Crystallography at a Synchrotron.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1101/2024.07.19.604369 
_citation.pdbx_database_id_PubMed   39071394 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Zielinski, K.A.' 1  ?                   
primary 'Dolamore, C.'    2  ?                   
primary 'Dalton, K.M.'    3  ?                   
primary 'Smith, N.'       4  ?                   
primary 'Termini, J.'     5  ?                   
primary 'Henning, R.'     6  ?                   
primary 'Srajer, V.'      7  ?                   
primary 'Hekstra, D.R.'   8  ?                   
primary 'Pollack, L.'     9  0000-0002-9366-4396 
primary 'Wilson, M.A.'    10 0000-0001-6317-900X 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Protein deglycase DJ-1' 20199.328 1   3.1.2.-,3.5.1.- ? ? ? 
2 non-polymer syn 1-hydroxypropan-2-one    74.079    1   ?               ? ? ? 
3 water       nat water                    18.015    127 ?               ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'DJ-1,Oncogene DJ1,Parkinson disease protein 7' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GSHMASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNL
GAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRG
PGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GSHMASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNL
GAQNLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRG
PGTSFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 1-hydroxypropan-2-one 4Y8 
3 water                 HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   SER n 
1 3   HIS n 
1 4   MET n 
1 5   ALA n 
1 6   SER n 
1 7   LYS n 
1 8   ARG n 
1 9   ALA n 
1 10  LEU n 
1 11  VAL n 
1 12  ILE n 
1 13  LEU n 
1 14  ALA n 
1 15  LYS n 
1 16  GLY n 
1 17  ALA n 
1 18  GLU n 
1 19  GLU n 
1 20  MET n 
1 21  GLU n 
1 22  THR n 
1 23  VAL n 
1 24  ILE n 
1 25  PRO n 
1 26  VAL n 
1 27  ASP n 
1 28  VAL n 
1 29  MET n 
1 30  ARG n 
1 31  ARG n 
1 32  ALA n 
1 33  GLY n 
1 34  ILE n 
1 35  LYS n 
1 36  VAL n 
1 37  THR n 
1 38  VAL n 
1 39  ALA n 
1 40  GLY n 
1 41  LEU n 
1 42  ALA n 
1 43  GLY n 
1 44  LYS n 
1 45  ASP n 
1 46  PRO n 
1 47  VAL n 
1 48  GLN n 
1 49  CYS n 
1 50  SER n 
1 51  ARG n 
1 52  ASP n 
1 53  VAL n 
1 54  VAL n 
1 55  ILE n 
1 56  CYS n 
1 57  PRO n 
1 58  ASP n 
1 59  ALA n 
1 60  SER n 
1 61  LEU n 
1 62  GLU n 
1 63  ASP n 
1 64  ALA n 
1 65  LYS n 
1 66  LYS n 
1 67  GLU n 
1 68  GLY n 
1 69  PRO n 
1 70  TYR n 
1 71  ASP n 
1 72  VAL n 
1 73  VAL n 
1 74  VAL n 
1 75  LEU n 
1 76  PRO n 
1 77  GLY n 
1 78  GLY n 
1 79  ASN n 
1 80  LEU n 
1 81  GLY n 
1 82  ALA n 
1 83  GLN n 
1 84  ASN n 
1 85  LEU n 
1 86  SER n 
1 87  GLU n 
1 88  SER n 
1 89  ALA n 
1 90  ALA n 
1 91  VAL n 
1 92  LYS n 
1 93  GLU n 
1 94  ILE n 
1 95  LEU n 
1 96  LYS n 
1 97  GLU n 
1 98  GLN n 
1 99  GLU n 
1 100 ASN n 
1 101 ARG n 
1 102 LYS n 
1 103 GLY n 
1 104 LEU n 
1 105 ILE n 
1 106 ALA n 
1 107 ALA n 
1 108 ILE n 
1 109 CYS n 
1 110 ALA n 
1 111 GLY n 
1 112 PRO n 
1 113 THR n 
1 114 ALA n 
1 115 LEU n 
1 116 LEU n 
1 117 ALA n 
1 118 HIS n 
1 119 GLU n 
1 120 ILE n 
1 121 GLY n 
1 122 PHE n 
1 123 GLY n 
1 124 SER n 
1 125 LYS n 
1 126 VAL n 
1 127 THR n 
1 128 THR n 
1 129 HIS n 
1 130 PRO n 
1 131 LEU n 
1 132 ALA n 
1 133 LYS n 
1 134 ASP n 
1 135 LYS n 
1 136 MET n 
1 137 MET n 
1 138 ASN n 
1 139 GLY n 
1 140 GLY n 
1 141 HIS n 
1 142 TYR n 
1 143 THR n 
1 144 TYR n 
1 145 SER n 
1 146 GLU n 
1 147 ASN n 
1 148 ARG n 
1 149 VAL n 
1 150 GLU n 
1 151 LYS n 
1 152 ASP n 
1 153 GLY n 
1 154 LEU n 
1 155 ILE n 
1 156 LEU n 
1 157 THR n 
1 158 SER n 
1 159 ARG n 
1 160 GLY n 
1 161 PRO n 
1 162 GLY n 
1 163 THR n 
1 164 SER n 
1 165 PHE n 
1 166 GLU n 
1 167 PHE n 
1 168 ALA n 
1 169 LEU n 
1 170 ALA n 
1 171 ILE n 
1 172 VAL n 
1 173 GLU n 
1 174 ALA n 
1 175 LEU n 
1 176 ASN n 
1 177 GLY n 
1 178 LYS n 
1 179 GLU n 
1 180 VAL n 
1 181 ALA n 
1 182 ALA n 
1 183 GLN n 
1 184 VAL n 
1 185 LYS n 
1 186 ALA n 
1 187 PRO n 
1 188 LEU n 
1 189 VAL n 
1 190 LEU n 
1 191 LYS n 
1 192 ASP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   192 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 PARK7 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          PLASMID 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       pET15b 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
4Y8 non-polymer         . 1-hydroxypropan-2-one ? 'C3 H6 O2'       74.079  
ALA 'L-peptide linking' y ALANINE               ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE              ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE            ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'       ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE              ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE             ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'       ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE               ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE             ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                 ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE            ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE               ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE            ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE         ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE               ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE             ? 'C4 H9 N O3'     119.119 
TYR 'L-peptide linking' y TYROSINE              ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   -2  ?   ?   ?   A . n 
A 1 2   SER 2   -1  ?   ?   ?   A . n 
A 1 3   HIS 3   0   ?   ?   ?   A . n 
A 1 4   MET 4   1   ?   ?   ?   A . n 
A 1 5   ALA 5   2   2   ALA ALA A . n 
A 1 6   SER 6   3   3   SER SER A . n 
A 1 7   LYS 7   4   4   LYS LYS A . n 
A 1 8   ARG 8   5   5   ARG ARG A . n 
A 1 9   ALA 9   6   6   ALA ALA A . n 
A 1 10  LEU 10  7   7   LEU LEU A . n 
A 1 11  VAL 11  8   8   VAL VAL A . n 
A 1 12  ILE 12  9   9   ILE ILE A . n 
A 1 13  LEU 13  10  10  LEU LEU A . n 
A 1 14  ALA 14  11  11  ALA ALA A . n 
A 1 15  LYS 15  12  12  LYS LYS A . n 
A 1 16  GLY 16  13  13  GLY GLY A . n 
A 1 17  ALA 17  14  14  ALA ALA A . n 
A 1 18  GLU 18  15  15  GLU GLU A . n 
A 1 19  GLU 19  16  16  GLU GLU A . n 
A 1 20  MET 20  17  17  MET MET A . n 
A 1 21  GLU 21  18  18  GLU GLU A . n 
A 1 22  THR 22  19  19  THR THR A . n 
A 1 23  VAL 23  20  20  VAL VAL A . n 
A 1 24  ILE 24  21  21  ILE ILE A . n 
A 1 25  PRO 25  22  22  PRO PRO A . n 
A 1 26  VAL 26  23  23  VAL VAL A . n 
A 1 27  ASP 27  24  24  ASP ASP A . n 
A 1 28  VAL 28  25  25  VAL VAL A . n 
A 1 29  MET 29  26  26  MET MET A . n 
A 1 30  ARG 30  27  27  ARG ARG A . n 
A 1 31  ARG 31  28  28  ARG ARG A . n 
A 1 32  ALA 32  29  29  ALA ALA A . n 
A 1 33  GLY 33  30  30  GLY GLY A . n 
A 1 34  ILE 34  31  31  ILE ILE A . n 
A 1 35  LYS 35  32  32  LYS LYS A . n 
A 1 36  VAL 36  33  33  VAL VAL A . n 
A 1 37  THR 37  34  34  THR THR A . n 
A 1 38  VAL 38  35  35  VAL VAL A . n 
A 1 39  ALA 39  36  36  ALA ALA A . n 
A 1 40  GLY 40  37  37  GLY GLY A . n 
A 1 41  LEU 41  38  38  LEU LEU A . n 
A 1 42  ALA 42  39  39  ALA ALA A . n 
A 1 43  GLY 43  40  40  GLY GLY A . n 
A 1 44  LYS 44  41  41  LYS LYS A . n 
A 1 45  ASP 45  42  42  ASP ASP A . n 
A 1 46  PRO 46  43  43  PRO PRO A . n 
A 1 47  VAL 47  44  44  VAL VAL A . n 
A 1 48  GLN 48  45  45  GLN GLN A . n 
A 1 49  CYS 49  46  46  CYS CYS A . n 
A 1 50  SER 50  47  47  SER SER A . n 
A 1 51  ARG 51  48  48  ARG ARG A . n 
A 1 52  ASP 52  49  49  ASP ASP A . n 
A 1 53  VAL 53  50  50  VAL VAL A . n 
A 1 54  VAL 54  51  51  VAL VAL A . n 
A 1 55  ILE 55  52  52  ILE ILE A . n 
A 1 56  CYS 56  53  53  CYS CYS A . n 
A 1 57  PRO 57  54  54  PRO PRO A . n 
A 1 58  ASP 58  55  55  ASP ASP A . n 
A 1 59  ALA 59  56  56  ALA ALA A . n 
A 1 60  SER 60  57  57  SER SER A . n 
A 1 61  LEU 61  58  58  LEU LEU A . n 
A 1 62  GLU 62  59  59  GLU GLU A . n 
A 1 63  ASP 63  60  60  ASP ASP A . n 
A 1 64  ALA 64  61  61  ALA ALA A . n 
A 1 65  LYS 65  62  62  LYS LYS A . n 
A 1 66  LYS 66  63  63  LYS LYS A . n 
A 1 67  GLU 67  64  64  GLU GLU A . n 
A 1 68  GLY 68  65  65  GLY GLY A . n 
A 1 69  PRO 69  66  66  PRO PRO A . n 
A 1 70  TYR 70  67  67  TYR TYR A . n 
A 1 71  ASP 71  68  68  ASP ASP A . n 
A 1 72  VAL 72  69  69  VAL VAL A . n 
A 1 73  VAL 73  70  70  VAL VAL A . n 
A 1 74  VAL 74  71  71  VAL VAL A . n 
A 1 75  LEU 75  72  72  LEU LEU A . n 
A 1 76  PRO 76  73  73  PRO PRO A . n 
A 1 77  GLY 77  74  74  GLY GLY A . n 
A 1 78  GLY 78  75  75  GLY GLY A . n 
A 1 79  ASN 79  76  76  ASN ASN A . n 
A 1 80  LEU 80  77  77  LEU LEU A . n 
A 1 81  GLY 81  78  78  GLY GLY A . n 
A 1 82  ALA 82  79  79  ALA ALA A . n 
A 1 83  GLN 83  80  80  GLN GLN A . n 
A 1 84  ASN 84  81  81  ASN ASN A . n 
A 1 85  LEU 85  82  82  LEU LEU A . n 
A 1 86  SER 86  83  83  SER SER A . n 
A 1 87  GLU 87  84  84  GLU GLU A . n 
A 1 88  SER 88  85  85  SER SER A . n 
A 1 89  ALA 89  86  86  ALA ALA A . n 
A 1 90  ALA 90  87  87  ALA ALA A . n 
A 1 91  VAL 91  88  88  VAL VAL A . n 
A 1 92  LYS 92  89  89  LYS LYS A . n 
A 1 93  GLU 93  90  90  GLU GLU A . n 
A 1 94  ILE 94  91  91  ILE ILE A . n 
A 1 95  LEU 95  92  92  LEU LEU A . n 
A 1 96  LYS 96  93  93  LYS LYS A . n 
A 1 97  GLU 97  94  94  GLU GLU A . n 
A 1 98  GLN 98  95  95  GLN GLN A . n 
A 1 99  GLU 99  96  96  GLU GLU A . n 
A 1 100 ASN 100 97  97  ASN ASN A . n 
A 1 101 ARG 101 98  98  ARG ARG A . n 
A 1 102 LYS 102 99  99  LYS LYS A . n 
A 1 103 GLY 103 100 100 GLY GLY A . n 
A 1 104 LEU 104 101 101 LEU LEU A . n 
A 1 105 ILE 105 102 102 ILE ILE A . n 
A 1 106 ALA 106 103 103 ALA ALA A . n 
A 1 107 ALA 107 104 104 ALA ALA A . n 
A 1 108 ILE 108 105 105 ILE ILE A . n 
A 1 109 CYS 109 106 106 CYS CYS A . n 
A 1 110 ALA 110 107 107 ALA ALA A . n 
A 1 111 GLY 111 108 108 GLY GLY A . n 
A 1 112 PRO 112 109 109 PRO PRO A . n 
A 1 113 THR 113 110 110 THR THR A . n 
A 1 114 ALA 114 111 111 ALA ALA A . n 
A 1 115 LEU 115 112 112 LEU LEU A . n 
A 1 116 LEU 116 113 113 LEU LEU A . n 
A 1 117 ALA 117 114 114 ALA ALA A . n 
A 1 118 HIS 118 115 115 HIS HIS A . n 
A 1 119 GLU 119 116 116 GLU GLU A . n 
A 1 120 ILE 120 117 117 ILE ILE A . n 
A 1 121 GLY 121 118 118 GLY GLY A . n 
A 1 122 PHE 122 119 119 PHE PHE A . n 
A 1 123 GLY 123 120 120 GLY GLY A . n 
A 1 124 SER 124 121 121 SER SER A . n 
A 1 125 LYS 125 122 122 LYS LYS A . n 
A 1 126 VAL 126 123 123 VAL VAL A . n 
A 1 127 THR 127 124 124 THR THR A . n 
A 1 128 THR 128 125 125 THR THR A . n 
A 1 129 HIS 129 126 126 HIS HIS A . n 
A 1 130 PRO 130 127 127 PRO PRO A . n 
A 1 131 LEU 131 128 128 LEU LEU A . n 
A 1 132 ALA 132 129 129 ALA ALA A . n 
A 1 133 LYS 133 130 130 LYS LYS A . n 
A 1 134 ASP 134 131 131 ASP ASP A . n 
A 1 135 LYS 135 132 132 LYS LYS A . n 
A 1 136 MET 136 133 133 MET MET A . n 
A 1 137 MET 137 134 134 MET MET A . n 
A 1 138 ASN 138 135 135 ASN ASN A . n 
A 1 139 GLY 139 136 136 GLY GLY A . n 
A 1 140 GLY 140 137 137 GLY GLY A . n 
A 1 141 HIS 141 138 138 HIS HIS A . n 
A 1 142 TYR 142 139 139 TYR TYR A . n 
A 1 143 THR 143 140 140 THR THR A . n 
A 1 144 TYR 144 141 141 TYR TYR A . n 
A 1 145 SER 145 142 142 SER SER A . n 
A 1 146 GLU 146 143 143 GLU GLU A . n 
A 1 147 ASN 147 144 144 ASN ASN A . n 
A 1 148 ARG 148 145 145 ARG ARG A . n 
A 1 149 VAL 149 146 146 VAL VAL A . n 
A 1 150 GLU 150 147 147 GLU GLU A . n 
A 1 151 LYS 151 148 148 LYS LYS A . n 
A 1 152 ASP 152 149 149 ASP ASP A . n 
A 1 153 GLY 153 150 150 GLY GLY A . n 
A 1 154 LEU 154 151 151 LEU LEU A . n 
A 1 155 ILE 155 152 152 ILE ILE A . n 
A 1 156 LEU 156 153 153 LEU LEU A . n 
A 1 157 THR 157 154 154 THR THR A . n 
A 1 158 SER 158 155 155 SER SER A . n 
A 1 159 ARG 159 156 156 ARG ARG A . n 
A 1 160 GLY 160 157 157 GLY GLY A . n 
A 1 161 PRO 161 158 158 PRO PRO A . n 
A 1 162 GLY 162 159 159 GLY GLY A . n 
A 1 163 THR 163 160 160 THR THR A . n 
A 1 164 SER 164 161 161 SER SER A . n 
A 1 165 PHE 165 162 162 PHE PHE A . n 
A 1 166 GLU 166 163 163 GLU GLU A . n 
A 1 167 PHE 167 164 164 PHE PHE A . n 
A 1 168 ALA 168 165 165 ALA ALA A . n 
A 1 169 LEU 169 166 166 LEU LEU A . n 
A 1 170 ALA 170 167 167 ALA ALA A . n 
A 1 171 ILE 171 168 168 ILE ILE A . n 
A 1 172 VAL 172 169 169 VAL VAL A . n 
A 1 173 GLU 173 170 170 GLU GLU A . n 
A 1 174 ALA 174 171 171 ALA ALA A . n 
A 1 175 LEU 175 172 172 LEU LEU A . n 
A 1 176 ASN 176 173 173 ASN ASN A . n 
A 1 177 GLY 177 174 174 GLY GLY A . n 
A 1 178 LYS 178 175 175 LYS LYS A . n 
A 1 179 GLU 179 176 176 GLU GLU A . n 
A 1 180 VAL 180 177 177 VAL VAL A . n 
A 1 181 ALA 181 178 178 ALA ALA A . n 
A 1 182 ALA 182 179 179 ALA ALA A . n 
A 1 183 GLN 183 180 180 GLN GLN A . n 
A 1 184 VAL 184 181 181 VAL VAL A . n 
A 1 185 LYS 185 182 182 LYS LYS A . n 
A 1 186 ALA 186 183 183 ALA ALA A . n 
A 1 187 PRO 187 184 184 PRO PRO A . n 
A 1 188 LEU 188 185 185 LEU LEU A . n 
A 1 189 VAL 189 186 186 VAL VAL A . n 
A 1 190 LEU 190 187 187 LEU LEU A . n 
A 1 191 LYS 191 188 188 LYS LYS A . n 
A 1 192 ASP 192 189 189 ASP ASP A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        4Y8 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   4Y8 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 4Y8 1   201 201 4Y8 LIG A . 
C 3 HOH 1   301 23  HOH HOH A . 
C 3 HOH 2   302 53  HOH HOH A . 
C 3 HOH 3   303 27  HOH HOH A . 
C 3 HOH 4   304 77  HOH HOH A . 
C 3 HOH 5   305 78  HOH HOH A . 
C 3 HOH 6   306 11  HOH HOH A . 
C 3 HOH 7   307 30  HOH HOH A . 
C 3 HOH 8   308 29  HOH HOH A . 
C 3 HOH 9   309 91  HOH HOH A . 
C 3 HOH 10  310 71  HOH HOH A . 
C 3 HOH 11  311 9   HOH HOH A . 
C 3 HOH 12  312 113 HOH HOH A . 
C 3 HOH 13  313 97  HOH HOH A . 
C 3 HOH 14  314 5   HOH HOH A . 
C 3 HOH 15  315 105 HOH HOH A . 
C 3 HOH 16  316 95  HOH HOH A . 
C 3 HOH 17  317 21  HOH HOH A . 
C 3 HOH 18  318 55  HOH HOH A . 
C 3 HOH 19  319 65  HOH HOH A . 
C 3 HOH 20  320 107 HOH HOH A . 
C 3 HOH 21  321 4   HOH HOH A . 
C 3 HOH 22  322 7   HOH HOH A . 
C 3 HOH 23  323 19  HOH HOH A . 
C 3 HOH 24  324 66  HOH HOH A . 
C 3 HOH 25  325 89  HOH HOH A . 
C 3 HOH 26  326 15  HOH HOH A . 
C 3 HOH 27  327 111 HOH HOH A . 
C 3 HOH 28  328 63  HOH HOH A . 
C 3 HOH 29  329 127 HOH HOH A . 
C 3 HOH 30  330 72  HOH HOH A . 
C 3 HOH 31  331 116 HOH HOH A . 
C 3 HOH 32  332 36  HOH HOH A . 
C 3 HOH 33  333 35  HOH HOH A . 
C 3 HOH 34  334 6   HOH HOH A . 
C 3 HOH 35  335 10  HOH HOH A . 
C 3 HOH 36  336 8   HOH HOH A . 
C 3 HOH 37  337 82  HOH HOH A . 
C 3 HOH 38  338 120 HOH HOH A . 
C 3 HOH 39  339 25  HOH HOH A . 
C 3 HOH 40  340 14  HOH HOH A . 
C 3 HOH 41  341 110 HOH HOH A . 
C 3 HOH 42  342 3   HOH HOH A . 
C 3 HOH 43  343 1   HOH HOH A . 
C 3 HOH 44  344 22  HOH HOH A . 
C 3 HOH 45  345 39  HOH HOH A . 
C 3 HOH 46  346 73  HOH HOH A . 
C 3 HOH 47  347 28  HOH HOH A . 
C 3 HOH 48  348 33  HOH HOH A . 
C 3 HOH 49  349 43  HOH HOH A . 
C 3 HOH 50  350 81  HOH HOH A . 
C 3 HOH 51  351 115 HOH HOH A . 
C 3 HOH 52  352 32  HOH HOH A . 
C 3 HOH 53  353 76  HOH HOH A . 
C 3 HOH 54  354 50  HOH HOH A . 
C 3 HOH 55  355 12  HOH HOH A . 
C 3 HOH 56  356 112 HOH HOH A . 
C 3 HOH 57  357 84  HOH HOH A . 
C 3 HOH 58  358 54  HOH HOH A . 
C 3 HOH 59  359 49  HOH HOH A . 
C 3 HOH 60  360 92  HOH HOH A . 
C 3 HOH 61  361 60  HOH HOH A . 
C 3 HOH 62  362 2   HOH HOH A . 
C 3 HOH 63  363 31  HOH HOH A . 
C 3 HOH 64  364 61  HOH HOH A . 
C 3 HOH 65  365 67  HOH HOH A . 
C 3 HOH 66  366 20  HOH HOH A . 
C 3 HOH 67  367 26  HOH HOH A . 
C 3 HOH 68  368 24  HOH HOH A . 
C 3 HOH 69  369 16  HOH HOH A . 
C 3 HOH 70  370 126 HOH HOH A . 
C 3 HOH 71  371 34  HOH HOH A . 
C 3 HOH 72  372 37  HOH HOH A . 
C 3 HOH 73  373 94  HOH HOH A . 
C 3 HOH 74  374 68  HOH HOH A . 
C 3 HOH 75  375 121 HOH HOH A . 
C 3 HOH 76  376 106 HOH HOH A . 
C 3 HOH 77  377 58  HOH HOH A . 
C 3 HOH 78  378 41  HOH HOH A . 
C 3 HOH 79  379 64  HOH HOH A . 
C 3 HOH 80  380 83  HOH HOH A . 
C 3 HOH 81  381 69  HOH HOH A . 
C 3 HOH 82  382 40  HOH HOH A . 
C 3 HOH 83  383 118 HOH HOH A . 
C 3 HOH 84  384 79  HOH HOH A . 
C 3 HOH 85  385 103 HOH HOH A . 
C 3 HOH 86  386 125 HOH HOH A . 
C 3 HOH 87  387 114 HOH HOH A . 
C 3 HOH 88  388 51  HOH HOH A . 
C 3 HOH 89  389 13  HOH HOH A . 
C 3 HOH 90  390 52  HOH HOH A . 
C 3 HOH 91  391 122 HOH HOH A . 
C 3 HOH 92  392 96  HOH HOH A . 
C 3 HOH 93  393 70  HOH HOH A . 
C 3 HOH 94  394 104 HOH HOH A . 
C 3 HOH 95  395 57  HOH HOH A . 
C 3 HOH 96  396 45  HOH HOH A . 
C 3 HOH 97  397 98  HOH HOH A . 
C 3 HOH 98  398 48  HOH HOH A . 
C 3 HOH 99  399 62  HOH HOH A . 
C 3 HOH 100 400 124 HOH HOH A . 
C 3 HOH 101 401 18  HOH HOH A . 
C 3 HOH 102 402 109 HOH HOH A . 
C 3 HOH 103 403 59  HOH HOH A . 
C 3 HOH 104 404 17  HOH HOH A . 
C 3 HOH 105 405 56  HOH HOH A . 
C 3 HOH 106 406 80  HOH HOH A . 
C 3 HOH 107 407 85  HOH HOH A . 
C 3 HOH 108 408 102 HOH HOH A . 
C 3 HOH 109 409 38  HOH HOH A . 
C 3 HOH 110 410 46  HOH HOH A . 
C 3 HOH 111 411 88  HOH HOH A . 
C 3 HOH 112 412 93  HOH HOH A . 
C 3 HOH 113 413 47  HOH HOH A . 
C 3 HOH 114 414 123 HOH HOH A . 
C 3 HOH 115 415 44  HOH HOH A . 
C 3 HOH 116 416 74  HOH HOH A . 
C 3 HOH 117 417 87  HOH HOH A . 
C 3 HOH 118 418 90  HOH HOH A . 
C 3 HOH 119 419 119 HOH HOH A . 
C 3 HOH 120 420 100 HOH HOH A . 
C 3 HOH 121 421 117 HOH HOH A . 
C 3 HOH 122 422 86  HOH HOH A . 
C 3 HOH 123 423 42  HOH HOH A . 
C 3 HOH 124 424 108 HOH HOH A . 
C 3 HOH 125 425 75  HOH HOH A . 
C 3 HOH 126 426 101 HOH HOH A . 
C 3 HOH 127 427 99  HOH HOH A . 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX       ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? Precognition ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? careless     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX       ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9CFM 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     76.030 
_cell.length_a_esd                 ? 
_cell.length_b                     76.030 
_cell.length_b_esd                 ? 
_cell.length_c                     76.140 
_cell.length_c_esd                 ? 
_cell.volume                       381165.412 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9CFM 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                152 
_symmetry.space_group_name_Hall            
;P 31 2"
;
_symmetry.space_group_name_H-M             'P 31 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9CFM 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             3.15 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          60.89 
_exptl_crystal.description                  '25 micron micro crystals' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'BATCH MODE' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              7.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '100 mM HEPES pH=7.5, 200 mM NaCl, and 15% PEG 3350' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     293 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   Y 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'RAYONIX MX340-HS' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-11-13 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   L 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             LAUE 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
loop_
_diffrn_radiation_wavelength.id 
_diffrn_radiation_wavelength.wavelength 
_diffrn_radiation_wavelength.wt 
1 1.240 1.0 
2 1.016 1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 14-ID-B' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.240-1.016 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   14-ID-B 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          -0.29 
_reflns.entry_id                                       9CFM 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.77 
_reflns.d_resolution_low                               65.84 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     25208 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.78 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                30.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          12.67 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.98 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.77 
_reflns_shell.d_res_low                                     1.83 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.56 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2455 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               10.2 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.34 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          99.68 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               17.47 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9CFM 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.77 
_refine.ls_d_res_low                             65.84 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     25177 
_refine.ls_number_reflns_R_free                  1145 
_refine.ls_number_reflns_R_work                  24032 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.81 
_refine.ls_percent_reflns_R_free                 4.55 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2062 
_refine.ls_R_factor_R_free                       0.2398 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2046 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.73 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'FOURIER SYNTHESIS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.6331 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2759 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.77 
_refine_hist.d_res_low                        65.84 
_refine_hist.number_atoms_solvent             127 
_refine_hist.number_atoms_total               1515 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1383 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         5 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0187  ? 1482 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.7741  ? 2012 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0797  ? 235  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0113  ? 267  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 13.8283 ? 578  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.77 1.85  . . 155 2940 99.74  . . . . 0.3256 . . . . . . . . . . . 0.3567 
'X-RAY DIFFRACTION' 1.85 1.95  . . 133 2969 100.00 . . . . 0.3073 . . . . . . . . . . . 0.3346 
'X-RAY DIFFRACTION' 1.95 2.07  . . 157 2949 100.00 . . . . 0.2413 . . . . . . . . . . . 0.2881 
'X-RAY DIFFRACTION' 2.07 2.23  . . 149 2976 100.00 . . . . 0.2147 . . . . . . . . . . . 0.2121 
'X-RAY DIFFRACTION' 2.23 2.45  . . 129 3036 100.00 . . . . 0.1600 . . . . . . . . . . . 0.2234 
'X-RAY DIFFRACTION' 2.45 2.81  . . 137 2994 100.00 . . . . 0.1546 . . . . . . . . . . . 0.2135 
'X-RAY DIFFRACTION' 2.81 3.54  . . 153 3021 99.91  . . . . 0.1454 . . . . . . . . . . . 0.1680 
'X-RAY DIFFRACTION' 3.54 65.84 . . 132 3147 98.85  . . . . 0.1356 . . . . . . . . . . . 0.1625 
# 
_struct.entry_id                     9CFM 
_struct.title                        'Human DJ-1, 5 sec mixing with methylglyoxal, pink beam time-resolved serial crystallography' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9CFM 
_struct_keywords.text            
'glutathione-independent glyoxalase, mix-and-inject serial crystallography, Laue diffraction, HYDROLASE' 
_struct_keywords.pdbx_keywords   HYDROLASE 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    PARK7_HUMAN 
_struct_ref.pdbx_db_accession          Q99497 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MASKRALVILAKGAEEMETVIPVDVMRRAGIKVTVAGLAGKDPVQCSRDVVICPDASLEDAKKEGPYDVVVLPGGNLGAQ
NLSESAAVKEILKEQENRKGLIAAICAGPTALLAHEIGFGSKVTTHPLAKDKMMNGGHYTYSENRVEKDGLILTSRGPGT
SFEFALAIVEALNGKEVAAQVKAPLVLKD
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9CFM 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 4 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 192 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q99497 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  189 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       1 
_struct_ref_seq.pdbx_auth_seq_align_end       189 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9CFM GLY A 1 ? UNP Q99497 ? ? 'expression tag' -2 1 
1 9CFM SER A 2 ? UNP Q99497 ? ? 'expression tag' -1 2 
1 9CFM HIS A 3 ? UNP Q99497 ? ? 'expression tag' 0  3 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 2820  ? 
1 MORE         -19   ? 
1 'SSA (A^2)'  15270 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1,2 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
loop_
_pdbx_struct_oper_list.id 
_pdbx_struct_oper_list.type 
_pdbx_struct_oper_list.name 
_pdbx_struct_oper_list.symmetry_operation 
_pdbx_struct_oper_list.matrix[1][1] 
_pdbx_struct_oper_list.matrix[1][2] 
_pdbx_struct_oper_list.matrix[1][3] 
_pdbx_struct_oper_list.vector[1] 
_pdbx_struct_oper_list.matrix[2][1] 
_pdbx_struct_oper_list.matrix[2][2] 
_pdbx_struct_oper_list.matrix[2][3] 
_pdbx_struct_oper_list.vector[2] 
_pdbx_struct_oper_list.matrix[3][1] 
_pdbx_struct_oper_list.matrix[3][2] 
_pdbx_struct_oper_list.matrix[3][3] 
_pdbx_struct_oper_list.vector[3] 
1 'identity operation'         1_555 x,y,z         1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  
0.0000000000 0.0000000000 0.0000000000 0.0000000000 1.0000000000  0.0000000000  
2 'crystal symmetry operation' 5_555 x-y,-y,-z+2/3 1.0000000000 0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 
0.0000000000 0.0000000000 0.0000000000 0.0000000000 -1.0000000000 50.7600000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLU A 18  ? ALA A 32  ? GLU A 15  ALA A 29  1 ? 15 
HELX_P HELX_P2  AA2 LEU A 61  ? LYS A 66  ? LEU A 58  LYS A 63  1 ? 6  
HELX_P HELX_P3  AA3 GLY A 78  ? SER A 88  ? GLY A 75  SER A 85  1 ? 11 
HELX_P HELX_P4  AA4 SER A 88  ? ARG A 101 ? SER A 85  ARG A 98  1 ? 14 
HELX_P HELX_P5  AA5 PRO A 112 ? HIS A 118 ? PRO A 109 HIS A 115 1 ? 7  
HELX_P HELX_P6  AA6 HIS A 129 ? LEU A 131 ? HIS A 126 LEU A 128 5 ? 3  
HELX_P HELX_P7  AA7 ALA A 132 ? MET A 137 ? ALA A 129 MET A 134 1 ? 6  
HELX_P HELX_P8  AA8 GLY A 160 ? GLY A 162 ? GLY A 157 GLY A 159 5 ? 3  
HELX_P HELX_P9  AA9 THR A 163 ? GLY A 177 ? THR A 160 GLY A 174 1 ? 15 
HELX_P HELX_P10 AB1 GLY A 177 ? ALA A 186 ? GLY A 174 ALA A 183 1 ? 10 
HELX_P HELX_P11 AB2 PRO A 187 ? VAL A 189 ? PRO A 184 VAL A 186 5 ? 3  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_conn.id                            covale1 
_struct_conn.conn_type_id                  covale 
_struct_conn.pdbx_leaving_atom_flag        one 
_struct_conn.pdbx_PDB_id                   ? 
_struct_conn.ptnr1_label_asym_id           A 
_struct_conn.ptnr1_label_comp_id           CYS 
_struct_conn.ptnr1_label_seq_id            109 
_struct_conn.ptnr1_label_atom_id           SG 
_struct_conn.pdbx_ptnr1_label_alt_id       ? 
_struct_conn.pdbx_ptnr1_PDB_ins_code       ? 
_struct_conn.pdbx_ptnr1_standard_comp_id   ? 
_struct_conn.ptnr1_symmetry                1_555 
_struct_conn.ptnr2_label_asym_id           B 
_struct_conn.ptnr2_label_comp_id           4Y8 
_struct_conn.ptnr2_label_seq_id            . 
_struct_conn.ptnr2_label_atom_id           CM1 
_struct_conn.pdbx_ptnr2_label_alt_id       ? 
_struct_conn.pdbx_ptnr2_PDB_ins_code       ? 
_struct_conn.ptnr1_auth_asym_id            A 
_struct_conn.ptnr1_auth_comp_id            CYS 
_struct_conn.ptnr1_auth_seq_id             106 
_struct_conn.ptnr2_auth_asym_id            A 
_struct_conn.ptnr2_auth_comp_id            4Y8 
_struct_conn.ptnr2_auth_seq_id             201 
_struct_conn.ptnr2_symmetry                1_555 
_struct_conn.pdbx_ptnr3_label_atom_id      ? 
_struct_conn.pdbx_ptnr3_label_seq_id       ? 
_struct_conn.pdbx_ptnr3_label_comp_id      ? 
_struct_conn.pdbx_ptnr3_label_asym_id      ? 
_struct_conn.pdbx_ptnr3_label_alt_id       ? 
_struct_conn.pdbx_ptnr3_PDB_ins_code       ? 
_struct_conn.details                       ? 
_struct_conn.pdbx_dist_value               1.758 
_struct_conn.pdbx_value_order              ? 
_struct_conn.pdbx_role                     ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      4Y8 
_pdbx_modification_feature.label_asym_id                      B 
_pdbx_modification_feature.label_seq_id                       . 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      109 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       4Y8 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        201 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       106 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               CM1 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                CYS 
_pdbx_modification_feature.ref_pcm_id                         2 
_pdbx_modification_feature.ref_comp_id                        4Y8 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Covalent chemical modification' 
# 
_struct_mon_prot_cis.pdbx_id                1 
_struct_mon_prot_cis.label_comp_id          GLY 
_struct_mon_prot_cis.label_seq_id           68 
_struct_mon_prot_cis.label_asym_id          A 
_struct_mon_prot_cis.label_alt_id           . 
_struct_mon_prot_cis.pdbx_PDB_ins_code      ? 
_struct_mon_prot_cis.auth_comp_id           GLY 
_struct_mon_prot_cis.auth_seq_id            65 
_struct_mon_prot_cis.auth_asym_id           A 
_struct_mon_prot_cis.pdbx_label_comp_id_2   PRO 
_struct_mon_prot_cis.pdbx_label_seq_id_2    69 
_struct_mon_prot_cis.pdbx_label_asym_id_2   A 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2    ? 
_struct_mon_prot_cis.pdbx_auth_comp_id_2    PRO 
_struct_mon_prot_cis.pdbx_auth_seq_id_2     66 
_struct_mon_prot_cis.pdbx_auth_asym_id_2    A 
_struct_mon_prot_cis.pdbx_PDB_model_num     1 
_struct_mon_prot_cis.pdbx_omega_angle       -8.91 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? parallel      
AA1 3 4 ? parallel      
AA1 4 5 ? parallel      
AA1 5 6 ? parallel      
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 59  ? SER A 60  ? ALA A 56  SER A 57  
AA1 2 LYS A 35  ? GLY A 40  ? LYS A 32  GLY A 37  
AA1 3 ARG A 8   ? LEU A 13  ? ARG A 5   LEU A 10  
AA1 4 VAL A 72  ? LEU A 75  ? VAL A 69  LEU A 72  
AA1 5 LEU A 104 ? ILE A 108 ? LEU A 101 ILE A 105 
AA1 6 ILE A 155 ? SER A 158 ? ILE A 152 SER A 155 
AA1 7 VAL A 149 ? ASP A 152 ? VAL A 146 ASP A 149 
AA2 1 VAL A 47  ? GLN A 48  ? VAL A 44  GLN A 45  
AA2 2 VAL A 54  ? ILE A 55  ? VAL A 51  ILE A 52  
AA3 1 LYS A 125 ? VAL A 126 ? LYS A 122 VAL A 123 
AA3 2 THR A 143 ? TYR A 144 ? THR A 140 TYR A 141 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O ALA A 59  ? O ALA A 56  N GLY A 40  ? N GLY A 37  
AA1 2 3 O ALA A 39  ? O ALA A 36  N LEU A 13  ? N LEU A 10  
AA1 3 4 N LEU A 10  ? N LEU A 7   O VAL A 74  ? O VAL A 71  
AA1 4 5 N LEU A 75  ? N LEU A 72  O ALA A 106 ? O ALA A 103 
AA1 5 6 N ILE A 105 ? N ILE A 102 O LEU A 156 ? O LEU A 153 
AA1 6 7 O THR A 157 ? O THR A 154 N GLU A 150 ? N GLU A 147 
AA2 1 2 N VAL A 47  ? N VAL A 44  O ILE A 55  ? O ILE A 52  
AA3 1 2 N VAL A 126 ? N VAL A 123 O THR A 143 ? O THR A 140 
# 
_pdbx_entry_details.entry_id                   9CFM 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 HZ2 A LYS 182 ? ? O A ASP 189 ? ? 1.54 
2 1 O   A HOH 420 ? ? O A HOH 426 ? ? 2.01 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 CB A LEU 72  ? ? CG A LEU 72  ? ? CD2 A LEU 72  ? ? 100.17 111.00 -10.83 1.70 N 
2 1 CB A ASP 149 ? ? CG A ASP 149 ? ? OD2 A ASP 149 ? ? 112.79 118.30 -5.51  0.90 N 
# 
_pdbx_validate_torsion.id              1 
_pdbx_validate_torsion.PDB_model_num   1 
_pdbx_validate_torsion.auth_comp_id    CYS 
_pdbx_validate_torsion.auth_asym_id    A 
_pdbx_validate_torsion.auth_seq_id     106 
_pdbx_validate_torsion.PDB_ins_code    ? 
_pdbx_validate_torsion.label_alt_id    ? 
_pdbx_validate_torsion.phi             73.45 
_pdbx_validate_torsion.psi             -108.05 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+1/3   
3 -x+y,-x,z+2/3  
4 x-y,-y,-z+2/3  
5 -x,-x+y,-z+1/3 
6 y,x,-z         
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       427 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.06 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 A GLY -2 ? A GLY 1 
2 1 Y 1 A SER -1 ? A SER 2 
3 1 Y 1 A HIS 0  ? A HIS 3 
4 1 Y 1 A MET 1  ? A MET 4 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
4Y8 O    O N N 1   
4Y8 C    C N N 2   
4Y8 CM2  C N N 3   
4Y8 CM1  C N N 4   
4Y8 O1   O N N 5   
4Y8 H1   H N N 6   
4Y8 H2   H N N 7   
4Y8 H3   H N N 8   
4Y8 H4   H N N 9   
4Y8 H5   H N N 10  
4Y8 H6   H N N 11  
ALA N    N N N 12  
ALA CA   C N S 13  
ALA C    C N N 14  
ALA O    O N N 15  
ALA CB   C N N 16  
ALA OXT  O N N 17  
ALA H    H N N 18  
ALA H2   H N N 19  
ALA HA   H N N 20  
ALA HB1  H N N 21  
ALA HB2  H N N 22  
ALA HB3  H N N 23  
ALA HXT  H N N 24  
ARG N    N N N 25  
ARG CA   C N S 26  
ARG C    C N N 27  
ARG O    O N N 28  
ARG CB   C N N 29  
ARG CG   C N N 30  
ARG CD   C N N 31  
ARG NE   N N N 32  
ARG CZ   C N N 33  
ARG NH1  N N N 34  
ARG NH2  N N N 35  
ARG OXT  O N N 36  
ARG H    H N N 37  
ARG H2   H N N 38  
ARG HA   H N N 39  
ARG HB2  H N N 40  
ARG HB3  H N N 41  
ARG HG2  H N N 42  
ARG HG3  H N N 43  
ARG HD2  H N N 44  
ARG HD3  H N N 45  
ARG HE   H N N 46  
ARG HH11 H N N 47  
ARG HH12 H N N 48  
ARG HH21 H N N 49  
ARG HH22 H N N 50  
ARG HXT  H N N 51  
ASN N    N N N 52  
ASN CA   C N S 53  
ASN C    C N N 54  
ASN O    O N N 55  
ASN CB   C N N 56  
ASN CG   C N N 57  
ASN OD1  O N N 58  
ASN ND2  N N N 59  
ASN OXT  O N N 60  
ASN H    H N N 61  
ASN H2   H N N 62  
ASN HA   H N N 63  
ASN HB2  H N N 64  
ASN HB3  H N N 65  
ASN HD21 H N N 66  
ASN HD22 H N N 67  
ASN HXT  H N N 68  
ASP N    N N N 69  
ASP CA   C N S 70  
ASP C    C N N 71  
ASP O    O N N 72  
ASP CB   C N N 73  
ASP CG   C N N 74  
ASP OD1  O N N 75  
ASP OD2  O N N 76  
ASP OXT  O N N 77  
ASP H    H N N 78  
ASP H2   H N N 79  
ASP HA   H N N 80  
ASP HB2  H N N 81  
ASP HB3  H N N 82  
ASP HD2  H N N 83  
ASP HXT  H N N 84  
CYS N    N N N 85  
CYS CA   C N R 86  
CYS C    C N N 87  
CYS O    O N N 88  
CYS CB   C N N 89  
CYS SG   S N N 90  
CYS OXT  O N N 91  
CYS H    H N N 92  
CYS H2   H N N 93  
CYS HA   H N N 94  
CYS HB2  H N N 95  
CYS HB3  H N N 96  
CYS HG   H N N 97  
CYS HXT  H N N 98  
GLN N    N N N 99  
GLN CA   C N S 100 
GLN C    C N N 101 
GLN O    O N N 102 
GLN CB   C N N 103 
GLN CG   C N N 104 
GLN CD   C N N 105 
GLN OE1  O N N 106 
GLN NE2  N N N 107 
GLN OXT  O N N 108 
GLN H    H N N 109 
GLN H2   H N N 110 
GLN HA   H N N 111 
GLN HB2  H N N 112 
GLN HB3  H N N 113 
GLN HG2  H N N 114 
GLN HG3  H N N 115 
GLN HE21 H N N 116 
GLN HE22 H N N 117 
GLN HXT  H N N 118 
GLU N    N N N 119 
GLU CA   C N S 120 
GLU C    C N N 121 
GLU O    O N N 122 
GLU CB   C N N 123 
GLU CG   C N N 124 
GLU CD   C N N 125 
GLU OE1  O N N 126 
GLU OE2  O N N 127 
GLU OXT  O N N 128 
GLU H    H N N 129 
GLU H2   H N N 130 
GLU HA   H N N 131 
GLU HB2  H N N 132 
GLU HB3  H N N 133 
GLU HG2  H N N 134 
GLU HG3  H N N 135 
GLU HE2  H N N 136 
GLU HXT  H N N 137 
GLY N    N N N 138 
GLY CA   C N N 139 
GLY C    C N N 140 
GLY O    O N N 141 
GLY OXT  O N N 142 
GLY H    H N N 143 
GLY H2   H N N 144 
GLY HA2  H N N 145 
GLY HA3  H N N 146 
GLY HXT  H N N 147 
HIS N    N N N 148 
HIS CA   C N S 149 
HIS C    C N N 150 
HIS O    O N N 151 
HIS CB   C N N 152 
HIS CG   C Y N 153 
HIS ND1  N Y N 154 
HIS CD2  C Y N 155 
HIS CE1  C Y N 156 
HIS NE2  N Y N 157 
HIS OXT  O N N 158 
HIS H    H N N 159 
HIS H2   H N N 160 
HIS HA   H N N 161 
HIS HB2  H N N 162 
HIS HB3  H N N 163 
HIS HD1  H N N 164 
HIS HD2  H N N 165 
HIS HE1  H N N 166 
HIS HE2  H N N 167 
HIS HXT  H N N 168 
HOH O    O N N 169 
HOH H1   H N N 170 
HOH H2   H N N 171 
ILE N    N N N 172 
ILE CA   C N S 173 
ILE C    C N N 174 
ILE O    O N N 175 
ILE CB   C N S 176 
ILE CG1  C N N 177 
ILE CG2  C N N 178 
ILE CD1  C N N 179 
ILE OXT  O N N 180 
ILE H    H N N 181 
ILE H2   H N N 182 
ILE HA   H N N 183 
ILE HB   H N N 184 
ILE HG12 H N N 185 
ILE HG13 H N N 186 
ILE HG21 H N N 187 
ILE HG22 H N N 188 
ILE HG23 H N N 189 
ILE HD11 H N N 190 
ILE HD12 H N N 191 
ILE HD13 H N N 192 
ILE HXT  H N N 193 
LEU N    N N N 194 
LEU CA   C N S 195 
LEU C    C N N 196 
LEU O    O N N 197 
LEU CB   C N N 198 
LEU CG   C N N 199 
LEU CD1  C N N 200 
LEU CD2  C N N 201 
LEU OXT  O N N 202 
LEU H    H N N 203 
LEU H2   H N N 204 
LEU HA   H N N 205 
LEU HB2  H N N 206 
LEU HB3  H N N 207 
LEU HG   H N N 208 
LEU HD11 H N N 209 
LEU HD12 H N N 210 
LEU HD13 H N N 211 
LEU HD21 H N N 212 
LEU HD22 H N N 213 
LEU HD23 H N N 214 
LEU HXT  H N N 215 
LYS N    N N N 216 
LYS CA   C N S 217 
LYS C    C N N 218 
LYS O    O N N 219 
LYS CB   C N N 220 
LYS CG   C N N 221 
LYS CD   C N N 222 
LYS CE   C N N 223 
LYS NZ   N N N 224 
LYS OXT  O N N 225 
LYS H    H N N 226 
LYS H2   H N N 227 
LYS HA   H N N 228 
LYS HB2  H N N 229 
LYS HB3  H N N 230 
LYS HG2  H N N 231 
LYS HG3  H N N 232 
LYS HD2  H N N 233 
LYS HD3  H N N 234 
LYS HE2  H N N 235 
LYS HE3  H N N 236 
LYS HZ1  H N N 237 
LYS HZ2  H N N 238 
LYS HZ3  H N N 239 
LYS HXT  H N N 240 
MET N    N N N 241 
MET CA   C N S 242 
MET C    C N N 243 
MET O    O N N 244 
MET CB   C N N 245 
MET CG   C N N 246 
MET SD   S N N 247 
MET CE   C N N 248 
MET OXT  O N N 249 
MET H    H N N 250 
MET H2   H N N 251 
MET HA   H N N 252 
MET HB2  H N N 253 
MET HB3  H N N 254 
MET HG2  H N N 255 
MET HG3  H N N 256 
MET HE1  H N N 257 
MET HE2  H N N 258 
MET HE3  H N N 259 
MET HXT  H N N 260 
PHE N    N N N 261 
PHE CA   C N S 262 
PHE C    C N N 263 
PHE O    O N N 264 
PHE CB   C N N 265 
PHE CG   C Y N 266 
PHE CD1  C Y N 267 
PHE CD2  C Y N 268 
PHE CE1  C Y N 269 
PHE CE2  C Y N 270 
PHE CZ   C Y N 271 
PHE OXT  O N N 272 
PHE H    H N N 273 
PHE H2   H N N 274 
PHE HA   H N N 275 
PHE HB2  H N N 276 
PHE HB3  H N N 277 
PHE HD1  H N N 278 
PHE HD2  H N N 279 
PHE HE1  H N N 280 
PHE HE2  H N N 281 
PHE HZ   H N N 282 
PHE HXT  H N N 283 
PRO N    N N N 284 
PRO CA   C N S 285 
PRO C    C N N 286 
PRO O    O N N 287 
PRO CB   C N N 288 
PRO CG   C N N 289 
PRO CD   C N N 290 
PRO OXT  O N N 291 
PRO H    H N N 292 
PRO HA   H N N 293 
PRO HB2  H N N 294 
PRO HB3  H N N 295 
PRO HG2  H N N 296 
PRO HG3  H N N 297 
PRO HD2  H N N 298 
PRO HD3  H N N 299 
PRO HXT  H N N 300 
SER N    N N N 301 
SER CA   C N S 302 
SER C    C N N 303 
SER O    O N N 304 
SER CB   C N N 305 
SER OG   O N N 306 
SER OXT  O N N 307 
SER H    H N N 308 
SER H2   H N N 309 
SER HA   H N N 310 
SER HB2  H N N 311 
SER HB3  H N N 312 
SER HG   H N N 313 
SER HXT  H N N 314 
THR N    N N N 315 
THR CA   C N S 316 
THR C    C N N 317 
THR O    O N N 318 
THR CB   C N R 319 
THR OG1  O N N 320 
THR CG2  C N N 321 
THR OXT  O N N 322 
THR H    H N N 323 
THR H2   H N N 324 
THR HA   H N N 325 
THR HB   H N N 326 
THR HG1  H N N 327 
THR HG21 H N N 328 
THR HG22 H N N 329 
THR HG23 H N N 330 
THR HXT  H N N 331 
TYR N    N N N 332 
TYR CA   C N S 333 
TYR C    C N N 334 
TYR O    O N N 335 
TYR CB   C N N 336 
TYR CG   C Y N 337 
TYR CD1  C Y N 338 
TYR CD2  C Y N 339 
TYR CE1  C Y N 340 
TYR CE2  C Y N 341 
TYR CZ   C Y N 342 
TYR OH   O N N 343 
TYR OXT  O N N 344 
TYR H    H N N 345 
TYR H2   H N N 346 
TYR HA   H N N 347 
TYR HB2  H N N 348 
TYR HB3  H N N 349 
TYR HD1  H N N 350 
TYR HD2  H N N 351 
TYR HE1  H N N 352 
TYR HE2  H N N 353 
TYR HH   H N N 354 
TYR HXT  H N N 355 
VAL N    N N N 356 
VAL CA   C N S 357 
VAL C    C N N 358 
VAL O    O N N 359 
VAL CB   C N N 360 
VAL CG1  C N N 361 
VAL CG2  C N N 362 
VAL OXT  O N N 363 
VAL H    H N N 364 
VAL H2   H N N 365 
VAL HA   H N N 366 
VAL HB   H N N 367 
VAL HG11 H N N 368 
VAL HG12 H N N 369 
VAL HG13 H N N 370 
VAL HG21 H N N 371 
VAL HG22 H N N 372 
VAL HG23 H N N 373 
VAL HXT  H N N 374 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
4Y8 O   C    doub N N 1   
4Y8 C   CM2  sing N N 2   
4Y8 C   CM1  sing N N 3   
4Y8 CM1 O1   sing N N 4   
4Y8 CM2 H1   sing N N 5   
4Y8 CM2 H2   sing N N 6   
4Y8 CM2 H3   sing N N 7   
4Y8 CM1 H4   sing N N 8   
4Y8 CM1 H5   sing N N 9   
4Y8 O1  H6   sing N N 10  
ALA N   CA   sing N N 11  
ALA N   H    sing N N 12  
ALA N   H2   sing N N 13  
ALA CA  C    sing N N 14  
ALA CA  CB   sing N N 15  
ALA CA  HA   sing N N 16  
ALA C   O    doub N N 17  
ALA C   OXT  sing N N 18  
ALA CB  HB1  sing N N 19  
ALA CB  HB2  sing N N 20  
ALA CB  HB3  sing N N 21  
ALA OXT HXT  sing N N 22  
ARG N   CA   sing N N 23  
ARG N   H    sing N N 24  
ARG N   H2   sing N N 25  
ARG CA  C    sing N N 26  
ARG CA  CB   sing N N 27  
ARG CA  HA   sing N N 28  
ARG C   O    doub N N 29  
ARG C   OXT  sing N N 30  
ARG CB  CG   sing N N 31  
ARG CB  HB2  sing N N 32  
ARG CB  HB3  sing N N 33  
ARG CG  CD   sing N N 34  
ARG CG  HG2  sing N N 35  
ARG CG  HG3  sing N N 36  
ARG CD  NE   sing N N 37  
ARG CD  HD2  sing N N 38  
ARG CD  HD3  sing N N 39  
ARG NE  CZ   sing N N 40  
ARG NE  HE   sing N N 41  
ARG CZ  NH1  sing N N 42  
ARG CZ  NH2  doub N N 43  
ARG NH1 HH11 sing N N 44  
ARG NH1 HH12 sing N N 45  
ARG NH2 HH21 sing N N 46  
ARG NH2 HH22 sing N N 47  
ARG OXT HXT  sing N N 48  
ASN N   CA   sing N N 49  
ASN N   H    sing N N 50  
ASN N   H2   sing N N 51  
ASN CA  C    sing N N 52  
ASN CA  CB   sing N N 53  
ASN CA  HA   sing N N 54  
ASN C   O    doub N N 55  
ASN C   OXT  sing N N 56  
ASN CB  CG   sing N N 57  
ASN CB  HB2  sing N N 58  
ASN CB  HB3  sing N N 59  
ASN CG  OD1  doub N N 60  
ASN CG  ND2  sing N N 61  
ASN ND2 HD21 sing N N 62  
ASN ND2 HD22 sing N N 63  
ASN OXT HXT  sing N N 64  
ASP N   CA   sing N N 65  
ASP N   H    sing N N 66  
ASP N   H2   sing N N 67  
ASP CA  C    sing N N 68  
ASP CA  CB   sing N N 69  
ASP CA  HA   sing N N 70  
ASP C   O    doub N N 71  
ASP C   OXT  sing N N 72  
ASP CB  CG   sing N N 73  
ASP CB  HB2  sing N N 74  
ASP CB  HB3  sing N N 75  
ASP CG  OD1  doub N N 76  
ASP CG  OD2  sing N N 77  
ASP OD2 HD2  sing N N 78  
ASP OXT HXT  sing N N 79  
CYS N   CA   sing N N 80  
CYS N   H    sing N N 81  
CYS N   H2   sing N N 82  
CYS CA  C    sing N N 83  
CYS CA  CB   sing N N 84  
CYS CA  HA   sing N N 85  
CYS C   O    doub N N 86  
CYS C   OXT  sing N N 87  
CYS CB  SG   sing N N 88  
CYS CB  HB2  sing N N 89  
CYS CB  HB3  sing N N 90  
CYS SG  HG   sing N N 91  
CYS OXT HXT  sing N N 92  
GLN N   CA   sing N N 93  
GLN N   H    sing N N 94  
GLN N   H2   sing N N 95  
GLN CA  C    sing N N 96  
GLN CA  CB   sing N N 97  
GLN CA  HA   sing N N 98  
GLN C   O    doub N N 99  
GLN C   OXT  sing N N 100 
GLN CB  CG   sing N N 101 
GLN CB  HB2  sing N N 102 
GLN CB  HB3  sing N N 103 
GLN CG  CD   sing N N 104 
GLN CG  HG2  sing N N 105 
GLN CG  HG3  sing N N 106 
GLN CD  OE1  doub N N 107 
GLN CD  NE2  sing N N 108 
GLN NE2 HE21 sing N N 109 
GLN NE2 HE22 sing N N 110 
GLN OXT HXT  sing N N 111 
GLU N   CA   sing N N 112 
GLU N   H    sing N N 113 
GLU N   H2   sing N N 114 
GLU CA  C    sing N N 115 
GLU CA  CB   sing N N 116 
GLU CA  HA   sing N N 117 
GLU C   O    doub N N 118 
GLU C   OXT  sing N N 119 
GLU CB  CG   sing N N 120 
GLU CB  HB2  sing N N 121 
GLU CB  HB3  sing N N 122 
GLU CG  CD   sing N N 123 
GLU CG  HG2  sing N N 124 
GLU CG  HG3  sing N N 125 
GLU CD  OE1  doub N N 126 
GLU CD  OE2  sing N N 127 
GLU OE2 HE2  sing N N 128 
GLU OXT HXT  sing N N 129 
GLY N   CA   sing N N 130 
GLY N   H    sing N N 131 
GLY N   H2   sing N N 132 
GLY CA  C    sing N N 133 
GLY CA  HA2  sing N N 134 
GLY CA  HA3  sing N N 135 
GLY C   O    doub N N 136 
GLY C   OXT  sing N N 137 
GLY OXT HXT  sing N N 138 
HIS N   CA   sing N N 139 
HIS N   H    sing N N 140 
HIS N   H2   sing N N 141 
HIS CA  C    sing N N 142 
HIS CA  CB   sing N N 143 
HIS CA  HA   sing N N 144 
HIS C   O    doub N N 145 
HIS C   OXT  sing N N 146 
HIS CB  CG   sing N N 147 
HIS CB  HB2  sing N N 148 
HIS CB  HB3  sing N N 149 
HIS CG  ND1  sing Y N 150 
HIS CG  CD2  doub Y N 151 
HIS ND1 CE1  doub Y N 152 
HIS ND1 HD1  sing N N 153 
HIS CD2 NE2  sing Y N 154 
HIS CD2 HD2  sing N N 155 
HIS CE1 NE2  sing Y N 156 
HIS CE1 HE1  sing N N 157 
HIS NE2 HE2  sing N N 158 
HIS OXT HXT  sing N N 159 
HOH O   H1   sing N N 160 
HOH O   H2   sing N N 161 
ILE N   CA   sing N N 162 
ILE N   H    sing N N 163 
ILE N   H2   sing N N 164 
ILE CA  C    sing N N 165 
ILE CA  CB   sing N N 166 
ILE CA  HA   sing N N 167 
ILE C   O    doub N N 168 
ILE C   OXT  sing N N 169 
ILE CB  CG1  sing N N 170 
ILE CB  CG2  sing N N 171 
ILE CB  HB   sing N N 172 
ILE CG1 CD1  sing N N 173 
ILE CG1 HG12 sing N N 174 
ILE CG1 HG13 sing N N 175 
ILE CG2 HG21 sing N N 176 
ILE CG2 HG22 sing N N 177 
ILE CG2 HG23 sing N N 178 
ILE CD1 HD11 sing N N 179 
ILE CD1 HD12 sing N N 180 
ILE CD1 HD13 sing N N 181 
ILE OXT HXT  sing N N 182 
LEU N   CA   sing N N 183 
LEU N   H    sing N N 184 
LEU N   H2   sing N N 185 
LEU CA  C    sing N N 186 
LEU CA  CB   sing N N 187 
LEU CA  HA   sing N N 188 
LEU C   O    doub N N 189 
LEU C   OXT  sing N N 190 
LEU CB  CG   sing N N 191 
LEU CB  HB2  sing N N 192 
LEU CB  HB3  sing N N 193 
LEU CG  CD1  sing N N 194 
LEU CG  CD2  sing N N 195 
LEU CG  HG   sing N N 196 
LEU CD1 HD11 sing N N 197 
LEU CD1 HD12 sing N N 198 
LEU CD1 HD13 sing N N 199 
LEU CD2 HD21 sing N N 200 
LEU CD2 HD22 sing N N 201 
LEU CD2 HD23 sing N N 202 
LEU OXT HXT  sing N N 203 
LYS N   CA   sing N N 204 
LYS N   H    sing N N 205 
LYS N   H2   sing N N 206 
LYS CA  C    sing N N 207 
LYS CA  CB   sing N N 208 
LYS CA  HA   sing N N 209 
LYS C   O    doub N N 210 
LYS C   OXT  sing N N 211 
LYS CB  CG   sing N N 212 
LYS CB  HB2  sing N N 213 
LYS CB  HB3  sing N N 214 
LYS CG  CD   sing N N 215 
LYS CG  HG2  sing N N 216 
LYS CG  HG3  sing N N 217 
LYS CD  CE   sing N N 218 
LYS CD  HD2  sing N N 219 
LYS CD  HD3  sing N N 220 
LYS CE  NZ   sing N N 221 
LYS CE  HE2  sing N N 222 
LYS CE  HE3  sing N N 223 
LYS NZ  HZ1  sing N N 224 
LYS NZ  HZ2  sing N N 225 
LYS NZ  HZ3  sing N N 226 
LYS OXT HXT  sing N N 227 
MET N   CA   sing N N 228 
MET N   H    sing N N 229 
MET N   H2   sing N N 230 
MET CA  C    sing N N 231 
MET CA  CB   sing N N 232 
MET CA  HA   sing N N 233 
MET C   O    doub N N 234 
MET C   OXT  sing N N 235 
MET CB  CG   sing N N 236 
MET CB  HB2  sing N N 237 
MET CB  HB3  sing N N 238 
MET CG  SD   sing N N 239 
MET CG  HG2  sing N N 240 
MET CG  HG3  sing N N 241 
MET SD  CE   sing N N 242 
MET CE  HE1  sing N N 243 
MET CE  HE2  sing N N 244 
MET CE  HE3  sing N N 245 
MET OXT HXT  sing N N 246 
PHE N   CA   sing N N 247 
PHE N   H    sing N N 248 
PHE N   H2   sing N N 249 
PHE CA  C    sing N N 250 
PHE CA  CB   sing N N 251 
PHE CA  HA   sing N N 252 
PHE C   O    doub N N 253 
PHE C   OXT  sing N N 254 
PHE CB  CG   sing N N 255 
PHE CB  HB2  sing N N 256 
PHE CB  HB3  sing N N 257 
PHE CG  CD1  doub Y N 258 
PHE CG  CD2  sing Y N 259 
PHE CD1 CE1  sing Y N 260 
PHE CD1 HD1  sing N N 261 
PHE CD2 CE2  doub Y N 262 
PHE CD2 HD2  sing N N 263 
PHE CE1 CZ   doub Y N 264 
PHE CE1 HE1  sing N N 265 
PHE CE2 CZ   sing Y N 266 
PHE CE2 HE2  sing N N 267 
PHE CZ  HZ   sing N N 268 
PHE OXT HXT  sing N N 269 
PRO N   CA   sing N N 270 
PRO N   CD   sing N N 271 
PRO N   H    sing N N 272 
PRO CA  C    sing N N 273 
PRO CA  CB   sing N N 274 
PRO CA  HA   sing N N 275 
PRO C   O    doub N N 276 
PRO C   OXT  sing N N 277 
PRO CB  CG   sing N N 278 
PRO CB  HB2  sing N N 279 
PRO CB  HB3  sing N N 280 
PRO CG  CD   sing N N 281 
PRO CG  HG2  sing N N 282 
PRO CG  HG3  sing N N 283 
PRO CD  HD2  sing N N 284 
PRO CD  HD3  sing N N 285 
PRO OXT HXT  sing N N 286 
SER N   CA   sing N N 287 
SER N   H    sing N N 288 
SER N   H2   sing N N 289 
SER CA  C    sing N N 290 
SER CA  CB   sing N N 291 
SER CA  HA   sing N N 292 
SER C   O    doub N N 293 
SER C   OXT  sing N N 294 
SER CB  OG   sing N N 295 
SER CB  HB2  sing N N 296 
SER CB  HB3  sing N N 297 
SER OG  HG   sing N N 298 
SER OXT HXT  sing N N 299 
THR N   CA   sing N N 300 
THR N   H    sing N N 301 
THR N   H2   sing N N 302 
THR CA  C    sing N N 303 
THR CA  CB   sing N N 304 
THR CA  HA   sing N N 305 
THR C   O    doub N N 306 
THR C   OXT  sing N N 307 
THR CB  OG1  sing N N 308 
THR CB  CG2  sing N N 309 
THR CB  HB   sing N N 310 
THR OG1 HG1  sing N N 311 
THR CG2 HG21 sing N N 312 
THR CG2 HG22 sing N N 313 
THR CG2 HG23 sing N N 314 
THR OXT HXT  sing N N 315 
TYR N   CA   sing N N 316 
TYR N   H    sing N N 317 
TYR N   H2   sing N N 318 
TYR CA  C    sing N N 319 
TYR CA  CB   sing N N 320 
TYR CA  HA   sing N N 321 
TYR C   O    doub N N 322 
TYR C   OXT  sing N N 323 
TYR CB  CG   sing N N 324 
TYR CB  HB2  sing N N 325 
TYR CB  HB3  sing N N 326 
TYR CG  CD1  doub Y N 327 
TYR CG  CD2  sing Y N 328 
TYR CD1 CE1  sing Y N 329 
TYR CD1 HD1  sing N N 330 
TYR CD2 CE2  doub Y N 331 
TYR CD2 HD2  sing N N 332 
TYR CE1 CZ   doub Y N 333 
TYR CE1 HE1  sing N N 334 
TYR CE2 CZ   sing Y N 335 
TYR CE2 HE2  sing N N 336 
TYR CZ  OH   sing N N 337 
TYR OH  HH   sing N N 338 
TYR OXT HXT  sing N N 339 
VAL N   CA   sing N N 340 
VAL N   H    sing N N 341 
VAL N   H2   sing N N 342 
VAL CA  C    sing N N 343 
VAL CA  CB   sing N N 344 
VAL CA  HA   sing N N 345 
VAL C   O    doub N N 346 
VAL C   OXT  sing N N 347 
VAL CB  CG1  sing N N 348 
VAL CB  CG2  sing N N 349 
VAL CB  HB   sing N N 350 
VAL CG1 HG11 sing N N 351 
VAL CG1 HG12 sing N N 352 
VAL CG1 HG13 sing N N 353 
VAL CG2 HG21 sing N N 354 
VAL CG2 HG22 sing N N 355 
VAL CG2 HG23 sing N N 356 
VAL OXT HXT  sing N N 357 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           R35GM153337 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'Unpublished room temperature DJ-1 X-ray crystal structure' 
# 
_pdbx_serial_crystallography_data_reduction.diffrn_id             1 
_pdbx_serial_crystallography_data_reduction.frames_total          25000 
_pdbx_serial_crystallography_data_reduction.xfel_pulse_events     ? 
_pdbx_serial_crystallography_data_reduction.frame_hits            ? 
_pdbx_serial_crystallography_data_reduction.crystal_hits          1169 
_pdbx_serial_crystallography_data_reduction.droplet_hits          ? 
_pdbx_serial_crystallography_data_reduction.frames_failed_index   ? 
_pdbx_serial_crystallography_data_reduction.frames_indexed        409 
_pdbx_serial_crystallography_data_reduction.lattices_indexed      ? 
_pdbx_serial_crystallography_data_reduction.xfel_run_numbers      ? 
_pdbx_serial_crystallography_data_reduction.lattices_merged       ? 
# 
_pdbx_serial_crystallography_sample_delivery.diffrn_id     1 
_pdbx_serial_crystallography_sample_delivery.description   'concentric flow injector' 
_pdbx_serial_crystallography_sample_delivery.method        injection 
# 
_pdbx_serial_crystallography_sample_delivery_injection.diffrn_id               1 
_pdbx_serial_crystallography_sample_delivery_injection.description             'flow-focused diffusive mixer' 
_pdbx_serial_crystallography_sample_delivery_injection.injector_diameter       ? 
_pdbx_serial_crystallography_sample_delivery_injection.injector_temperature    ? 
_pdbx_serial_crystallography_sample_delivery_injection.injector_pressure       ? 
_pdbx_serial_crystallography_sample_delivery_injection.flow_rate               1 
_pdbx_serial_crystallography_sample_delivery_injection.carrier_solvent         ? 
_pdbx_serial_crystallography_sample_delivery_injection.crystal_concentration   ? 
_pdbx_serial_crystallography_sample_delivery_injection.preparation             ? 
_pdbx_serial_crystallography_sample_delivery_injection.power_by                ? 
_pdbx_serial_crystallography_sample_delivery_injection.injector_nozzle         ? 
_pdbx_serial_crystallography_sample_delivery_injection.jet_diameter            ? 
_pdbx_serial_crystallography_sample_delivery_injection.filter_size             ? 
# 
_space_group.name_H-M_alt     'P 31 2 1' 
_space_group.name_Hall        
;P 31 2"
;
_space_group.IT_number        152 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9CFM 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.013153 
_atom_sites.fract_transf_matrix[1][2]   0.007594 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.015187 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.013134 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
H ? ? 0.51345 0.48472 ? ? 24.73122 6.32584  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ALA A 1 5   ? 31.24723 9.13662   -0.83071 1.000 65.54357  ? 2   ALA A N    1 
ATOM   2    C CA   . ALA A 1 5   ? 32.69671 8.90814   -0.75096 1.000 81.98283  ? 2   ALA A CA   1 
ATOM   3    C C    . ALA A 1 5   ? 33.07295 8.48357   0.69902  1.000 80.16310  ? 2   ALA A C    1 
ATOM   4    O O    . ALA A 1 5   ? 34.22525 8.61047   1.15013  1.000 63.98439  ? 2   ALA A O    1 
ATOM   5    C CB   . ALA A 1 5   ? 33.48894 10.18367  -1.21236 1.000 62.62907  ? 2   ALA A CB   1 
ATOM   6    H HA   . ALA A 1 5   ? 32.95843 8.19550   -1.35473 1.000 98.37942  ? 2   ALA A HA   1 
ATOM   7    H HB1  . ALA A 1 5   ? 34.44017 10.00707  -1.14241 1.000 75.15490  ? 2   ALA A HB1  1 
ATOM   8    H HB2  . ALA A 1 5   ? 33.25651 10.38409  -2.13252 1.000 75.15490  ? 2   ALA A HB2  1 
ATOM   9    H HB3  . ALA A 1 5   ? 33.24797 10.92913  -0.64042 1.000 75.15490  ? 2   ALA A HB3  1 
ATOM   10   N N    . SER A 1 6   ? 32.08399 7.96746   1.42946  1.000 58.84826  ? 3   SER A N    1 
ATOM   11   C CA   . SER A 1 6   ? 32.27074 7.56826   2.82500  1.000 61.56190  ? 3   SER A CA   1 
ATOM   12   C C    . SER A 1 6   ? 32.40730 6.03738   2.93410  1.000 23.10621  ? 3   SER A C    1 
ATOM   13   O O    . SER A 1 6   ? 31.53288 5.29842   2.46353  1.000 43.41752  ? 3   SER A O    1 
ATOM   14   C CB   . SER A 1 6   ? 31.09275 8.11254   3.65605  1.000 62.61387  ? 3   SER A CB   1 
ATOM   15   O OG   . SER A 1 6   ? 31.41158 8.21877   5.03529  1.000 62.76536  ? 3   SER A OG   1 
ATOM   16   H H    . SER A 1 6   ? 31.28644 7.83734   1.13521  1.000 70.61793  ? 3   SER A H    1 
ATOM   17   H HA   . SER A 1 6   ? 33.09673 7.92862   3.18386  1.000 73.87430  ? 3   SER A HA   1 
ATOM   18   H HB2  . SER A 1 6   ? 30.85907 8.99313   3.32308  1.000 75.13666  ? 3   SER A HB2  1 
ATOM   19   H HB3  . SER A 1 6   ? 30.33912 7.50985   3.55752  1.000 75.13666  ? 3   SER A HB3  1 
ATOM   20   H HG   . SER A 1 6   ? 30.76040 8.54127   5.45668  1.000 75.31844  ? 3   SER A HG   1 
ATOM   21   N N    . LYS A 1 7   ? 33.51832 5.56996   3.53152  1.000 24.13147  ? 4   LYS A N    1 
ATOM   22   C CA   . LYS A 1 7   ? 33.69899 4.13000   3.81769  1.000 25.40549  ? 4   LYS A CA   1 
ATOM   23   C C    . LYS A 1 7   ? 32.73151 3.66775   4.90448  1.000 15.16676  ? 4   LYS A C    1 
ATOM   24   O O    . LYS A 1 7   ? 32.35356 4.43837   5.79767  1.000 19.08864  ? 4   LYS A O    1 
ATOM   25   C CB   . LYS A 1 7   ? 35.12015 3.79755   4.30354  1.000 27.15768  ? 4   LYS A CB   1 
ATOM   26   C CG   . LYS A 1 7   ? 36.29131 4.26821   3.47784  1.000 18.90289  ? 4   LYS A CG   1 
ATOM   27   C CD   . LYS A 1 7   ? 36.58456 3.36153   2.32216  1.000 35.59266  ? 4   LYS A CD   1 
ATOM   28   C CE   . LYS A 1 7   ? 37.76406 3.91453   1.50587  1.000 34.29950  ? 4   LYS A CE   1 
ATOM   29   N NZ   . LYS A 1 7   ? 38.30362 2.95313   0.50373  1.000 43.50686  ? 4   LYS A NZ   1 
ATOM   30   H H    . LYS A 1 7   ? 34.17921 6.06079   3.78035  1.000 28.95778  ? 4   LYS A H    1 
ATOM   31   H HA   . LYS A 1 7   ? 33.53693 3.65525   2.98748  1.000 30.48660  ? 4   LYS A HA   1 
ATOM   32   H HB2  . LYS A 1 7   ? 35.22831 4.18981   5.18407  1.000 32.58923  ? 4   LYS A HB2  1 
ATOM   33   H HB3  . LYS A 1 7   ? 35.19259 2.83187   4.35936  1.000 32.58923  ? 4   LYS A HB3  1 
ATOM   34   H HG2  . LYS A 1 7   ? 36.09596 5.15034   3.12487  1.000 22.68348  ? 4   LYS A HG2  1 
ATOM   35   H HG3  . LYS A 1 7   ? 37.08133 4.30312   4.03958  1.000 22.68348  ? 4   LYS A HG3  1 
ATOM   36   H HD2  . LYS A 1 7   ? 36.81958 2.47941   2.65006  1.000 42.71121  ? 4   LYS A HD2  1 
ATOM   37   H HD3  . LYS A 1 7   ? 35.80663 3.30474   1.74553  1.000 42.71121  ? 4   LYS A HD3  1 
ATOM   38   H HE2  . LYS A 1 7   ? 37.46959 4.70548   1.02776  1.000 41.15942  ? 4   LYS A HE2  1 
ATOM   39   H HE3  . LYS A 1 7   ? 38.48463 4.14330   2.11360  1.000 41.15942  ? 4   LYS A HE3  1 
ATOM   40   H HZ1  . LYS A 1 7   ? 38.97616 3.32595   0.05562  1.000 52.20825  ? 4   LYS A HZ1  1 
ATOM   41   H HZ2  . LYS A 1 7   ? 38.60031 2.22086   0.91343  1.000 52.20825  ? 4   LYS A HZ2  1 
ATOM   42   H HZ3  . LYS A 1 7   ? 37.66512 2.72330   -0.07211 1.000 52.20825  ? 4   LYS A HZ3  1 
ATOM   43   N N    . ARG A 1 8   ? 32.33662 2.40267   4.83744  1.000 12.01399  ? 5   ARG A N    1 
ATOM   44   C CA   . ARG A 1 8   ? 31.25193 1.86841   5.64821  1.000 15.45835  ? 5   ARG A CA   1 
ATOM   45   C C    . ARG A 1 8   ? 31.78172 0.62236   6.34362  1.000 19.68973  ? 5   ARG A C    1 
ATOM   46   O O    . ARG A 1 8   ? 32.50977 -0.17340  5.74227  1.000 8.00810   ? 5   ARG A O    1 
ATOM   47   C CB   . ARG A 1 8   ? 30.00073 1.49833   4.83088  1.000 21.04886  ? 5   ARG A CB   1 
ATOM   48   C CG   . ARG A 1 8   ? 29.44735 2.57139   3.88107  1.000 32.96189  ? 5   ARG A CG   1 
ATOM   49   C CD   . ARG A 1 8   ? 28.37648 1.94410   2.99602  1.000 38.58438  ? 5   ARG A CD   1 
ATOM   50   N NE   . ARG A 1 8   ? 27.11079 2.18747   3.65512  1.000 47.16859  ? 5   ARG A NE   1 
ATOM   51   C CZ   . ARG A 1 8   ? 26.46001 3.32994   3.50395  1.000 79.90786  ? 5   ARG A CZ   1 
ATOM   52   N NH1  . ARG A 1 8   ? 26.90478 4.26580   2.67772  1.000 67.19311  ? 5   ARG A NH1  1 
ATOM   53   N NH2  . ARG A 1 8   ? 25.33683 3.53470   4.18489  1.000 69.98101  ? 5   ARG A NH2  1 
ATOM   54   H H    . ARG A 1 8   ? 32.69196 1.81908   4.31517  1.000 14.41681  ? 5   ARG A H    1 
ATOM   55   H HA   . ARG A 1 8   ? 30.97004 2.53810   6.29083  1.000 18.55003  ? 5   ARG A HA   1 
ATOM   56   H HB2  . ARG A 1 8   ? 30.21625 0.72422   4.28755  1.000 25.25865  ? 5   ARG A HB2  1 
ATOM   57   H HB3  . ARG A 1 8   ? 29.29029 1.27902   5.45383  1.000 25.25865  ? 5   ARG A HB3  1 
ATOM   58   H HG2  . ARG A 1 8   ? 29.05052 3.29357   4.39283  1.000 39.55428  ? 5   ARG A HG2  1 
ATOM   59   H HG3  . ARG A 1 8   ? 30.15945 2.91519   3.31926  1.000 39.55428  ? 5   ARG A HG3  1 
ATOM   60   H HD2  . ARG A 1 8   ? 28.37319 2.35898   2.11923  1.000 46.30127  ? 5   ARG A HD2  1 
ATOM   61   H HD3  . ARG A 1 8   ? 28.52179 0.98887   2.91051  1.000 46.30127  ? 5   ARG A HD3  1 
ATOM   62   H HE   . ARG A 1 8   ? 26.77389 1.57540   4.15659  1.000 56.60232  ? 5   ARG A HE   1 
ATOM   63   H HH11 . ARG A 1 8   ? 27.62704 4.13565   2.22938  1.000 80.63175  ? 5   ARG A HH11 1 
ATOM   64   H HH12 . ARG A 1 8   ? 26.47114 5.00325   2.58988  1.000 80.63175  ? 5   ARG A HH12 1 
ATOM   65   H HH21 . ARG A 1 8   ? 25.03996 2.92793   4.71714  1.000 83.97722  ? 5   ARG A HH21 1 
ATOM   66   H HH22 . ARG A 1 8   ? 24.90707 4.27396   4.09317  1.000 83.97722  ? 5   ARG A HH22 1 
ATOM   67   N N    . ALA A 1 9   ? 31.46505 0.48013   7.62313  1.000 9.59669   ? 6   ALA A N    1 
ATOM   68   C CA   . ALA A 1 9   ? 31.90829 -0.65722  8.39422  1.000 7.68732   ? 6   ALA A CA   1 
ATOM   69   C C    . ALA A 1 9   ? 30.71706 -1.29026  9.06935  1.000 8.39266   ? 6   ALA A C    1 
ATOM   70   O O    . ALA A 1 9   ? 29.82658 -0.59220  9.57681  1.000 7.18846   ? 6   ALA A O    1 
ATOM   71   C CB   . ALA A 1 9   ? 32.93188 -0.22647  9.44929  1.000 7.21663   ? 6   ALA A CB   1 
ATOM   72   H H    . ALA A 1 9   ? 30.98744 1.04043   8.06758  1.000 11.51605  ? 6   ALA A H    1 
ATOM   73   H HA   . ALA A 1 9   ? 32.31837 -1.31700  7.81334  1.000 9.22480   ? 6   ALA A HA   1 
ATOM   74   H HB1  . ALA A 1 9   ? 33.23302 -1.00993  9.93550  1.000 8.65997   ? 6   ALA A HB1  1 
ATOM   75   H HB2  . ALA A 1 9   ? 33.68358 0.19673   9.00574  1.000 8.65997   ? 6   ALA A HB2  1 
ATOM   76   H HB3  . ALA A 1 9   ? 32.51211 0.40021   10.05919 1.000 8.65997   ? 6   ALA A HB3  1 
ATOM   77   N N    . LEU A 1 10  ? 30.68327 -2.61979  9.04667  1.000 5.82837   ? 7   LEU A N    1 
ATOM   78   C CA   . LEU A 1 10  ? 29.64528 -3.39095  9.71405  1.000 5.71811   ? 7   LEU A CA   1 
ATOM   79   C C    . LEU A 1 10  ? 30.31628 -4.07326  10.88624 1.000 9.23240   ? 7   LEU A C    1 
ATOM   80   O O    . LEU A 1 10  ? 31.26821 -4.82106  10.68251 1.000 8.78051   ? 7   LEU A O    1 
ATOM   81   C CB   . LEU A 1 10  ? 29.08233 -4.48018  8.82922  1.000 5.50643   ? 7   LEU A CB   1 
ATOM   82   C CG   . LEU A 1 10  ? 28.00299 -5.36057  9.45414  1.000 18.47041  ? 7   LEU A CG   1 
ATOM   83   C CD1  . LEU A 1 10  ? 26.81617 -4.44404  9.69584  1.000 14.45607  ? 7   LEU A CD1  1 
ATOM   84   C CD2  . LEU A 1 10  ? 27.74956 -6.44297  8.41593  1.000 13.97856  ? 7   LEU A CD2  1 
ATOM   85   H H    . LEU A 1 10  ? 31.26536 -3.10592  8.64114  1.000 6.99405   ? 7   LEU A H    1 
ATOM   86   H HA   . LEU A 1 10  ? 28.92634 -2.79679  9.98051  1.000 6.86175   ? 7   LEU A HA   1 
ATOM   87   H HB2  . LEU A 1 10  ? 28.69316 -4.06181  8.04538  1.000 6.60773   ? 7   LEU A HB2  1 
ATOM   88   H HB3  . LEU A 1 10  ? 29.81168 -5.06320  8.56647  1.000 6.60773   ? 7   LEU A HB3  1 
ATOM   89   H HG   . LEU A 1 10  ? 28.21376 -5.78827  10.29886 1.000 22.16451  ? 7   LEU A HG   1 
ATOM   90   H HD11 . LEU A 1 10  ? 26.04109 -4.98307  9.91853  1.000 17.34730  ? 7   LEU A HD11 1 
ATOM   91   H HD12 . LEU A 1 10  ? 27.02423 -3.84479  10.42968 1.000 17.34730  ? 7   LEU A HD12 1 
ATOM   92   H HD13 . LEU A 1 10  ? 26.64292 -3.93256  8.89007  1.000 17.34730  ? 7   LEU A HD13 1 
ATOM   93   H HD21 . LEU A 1 10  ? 27.03065 -7.01570  8.72585  1.000 16.77429  ? 7   LEU A HD21 1 
ATOM   94   H HD22 . LEU A 1 10  ? 27.50056 -6.02402  7.57725  1.000 16.77429  ? 7   LEU A HD22 1 
ATOM   95   H HD23 . LEU A 1 10  ? 28.55962 -6.96336  8.29805  1.000 16.77429  ? 7   LEU A HD23 1 
ATOM   96   N N    . VAL A 1 11  ? 29.78335 -3.87886  12.07265 1.000 6.64714   ? 8   VAL A N    1 
ATOM   97   C CA   . VAL A 1 11  ? 30.22234 -4.56003  13.27977 1.000 5.75598   ? 8   VAL A CA   1 
ATOM   98   C C    . VAL A 1 11  ? 29.05831 -5.43282  13.69541 1.000 5.33103   ? 8   VAL A C    1 
ATOM   99   O O    . VAL A 1 11  ? 27.95984 -4.91838  13.85780 1.000 9.31957   ? 8   VAL A O    1 
ATOM   100  C CB   . VAL A 1 11  ? 30.55394 -3.51882  14.34564 1.000 3.80404   ? 8   VAL A CB   1 
ATOM   101  C CG1  . VAL A 1 11  ? 30.91902 -4.13551  15.55987 1.000 8.62436   ? 8   VAL A CG1  1 
ATOM   102  C CG2  . VAL A 1 11  ? 31.63916 -2.68851  13.82462 1.000 8.10722   ? 8   VAL A CG2  1 
ATOM   103  H H    . VAL A 1 11  ? 29.13501 -3.33207  12.21508 1.000 7.97659   ? 8   VAL A H    1 
ATOM   104  H HA   . VAL A 1 11  ? 31.00003 -5.12128  13.13456 1.000 6.90719   ? 8   VAL A HA   1 
ATOM   105  H HB   . VAL A 1 11  ? 29.77978 -2.96823  14.54169 1.000 4.56487   ? 8   VAL A HB   1 
ATOM   106  H HG11 . VAL A 1 11  ? 31.31227 -3.47032  16.14618 1.000 10.34925  ? 8   VAL A HG11 1 
ATOM   107  H HG12 . VAL A 1 11  ? 30.12685 -4.51349  15.97278 1.000 10.34925  ? 8   VAL A HG12 1 
ATOM   108  H HG13 . VAL A 1 11  ? 31.56325 -4.83712  15.37653 1.000 10.34925  ? 8   VAL A HG13 1 
ATOM   109  H HG21 . VAL A 1 11  ? 31.71557 -1.88997  14.36995 1.000 9.72868   ? 8   VAL A HG21 1 
ATOM   110  H HG22 . VAL A 1 11  ? 32.46702 -3.19288  13.85880 1.000 9.72868   ? 8   VAL A HG22 1 
ATOM   111  H HG23 . VAL A 1 11  ? 31.43795 -2.44479  12.90755 1.000 9.72868   ? 8   VAL A HG23 1 
ATOM   112  N N    . ILE A 1 12  ? 29.26143 -6.75303  13.83766 1.000 4.18036   ? 9   ILE A N    1 
ATOM   113  C CA   . ILE A 1 12  ? 28.19782 -7.71684  14.14092 1.000 2.00082   ? 9   ILE A CA   1 
ATOM   114  C C    . ILE A 1 12  ? 28.21812 -8.04679  15.62890 1.000 7.87585   ? 9   ILE A C    1 
ATOM   115  O O    . ILE A 1 12  ? 29.21327 -8.57196  16.15250 1.000 7.65913   ? 9   ILE A O    1 
ATOM   116  C CB   . ILE A 1 12  ? 28.34732 -9.02123  13.32432 1.000 9.77315   ? 9   ILE A CB   1 
ATOM   117  C CG1  . ILE A 1 12  ? 28.33619 -8.74168  11.83170 1.000 7.37864   ? 9   ILE A CG1  1 
ATOM   118  C CG2  . ILE A 1 12  ? 27.22102 -9.99338  13.66717 1.000 5.70473   ? 9   ILE A CG2  1 
ATOM   119  C CD1  . ILE A 1 12  ? 28.50674 -10.00341 11.07863 1.000 12.64657  ? 9   ILE A CD1  1 
ATOM   120  H H    . ILE A 1 12  ? 30.03385 -7.12304  13.75979 1.000 5.01644   ? 9   ILE A H    1 
ATOM   121  H HA   . ILE A 1 12  ? 27.35270 -7.29262  13.92481 1.000 2.40100   ? 9   ILE A HA   1 
ATOM   122  H HB   . ILE A 1 12  ? 29.20212 -9.41515  13.55894 1.000 11.72780  ? 9   ILE A HB   1 
ATOM   123  H HG12 . ILE A 1 12  ? 27.48900 -8.34118  11.58117 1.000 8.85438   ? 9   ILE A HG12 1 
ATOM   124  H HG13 . ILE A 1 12  ? 29.06556 -8.14318  11.60649 1.000 8.85438   ? 9   ILE A HG13 1 
ATOM   125  H HG21 . ILE A 1 12  ? 27.39319 -10.84259 13.23116 1.000 6.84569   ? 9   ILE A HG21 1 
ATOM   126  H HG22 . ILE A 1 12  ? 27.19106 -10.11545 14.62899 1.000 6.84569   ? 9   ILE A HG22 1 
ATOM   127  H HG23 . ILE A 1 12  ? 26.37994 -9.62533  13.35409 1.000 6.84569   ? 9   ILE A HG23 1 
ATOM   128  H HD11 . ILE A 1 12  ? 28.76771 -9.79485  10.16797 1.000 15.17591  ? 9   ILE A HD11 1 
ATOM   129  H HD12 . ILE A 1 12  ? 29.19552 -10.53586 11.50639 1.000 15.17591  ? 9   ILE A HD12 1 
ATOM   130  H HD13 . ILE A 1 12  ? 27.66624 -10.48762 11.07921 1.000 15.17591  ? 9   ILE A HD13 1 
ATOM   131  N N    . LEU A 1 13  ? 27.12104 -7.77446  16.30752 1.000 4.30807   ? 10  LEU A N    1 
ATOM   132  C CA   . LEU A 1 13  ? 27.09844 -7.79277  17.77557 1.000 8.80470   ? 10  LEU A CA   1 
ATOM   133  C C    . LEU A 1 13  ? 26.15117 -8.87593  18.22552 1.000 9.64427   ? 10  LEU A C    1 
ATOM   134  O O    . LEU A 1 13  ? 24.94233 -8.79034  17.95392 1.000 6.31870   ? 10  LEU A O    1 
ATOM   135  C CB   . LEU A 1 13  ? 26.65009 -6.44706  18.30582 1.000 11.27072  ? 10  LEU A CB   1 
ATOM   136  C CG   . LEU A 1 13  ? 26.46359 -6.30196  19.81677 1.000 16.28767  ? 10  LEU A CG   1 
ATOM   137  C CD1  . LEU A 1 13  ? 27.73808 -6.74895  20.50055 1.000 11.68379  ? 10  LEU A CD1  1 
ATOM   138  C CD2  . LEU A 1 13  ? 26.12650 -4.87793  20.27555 1.000 14.43872  ? 10  LEU A CD2  1 
ATOM   139  H H    . LEU A 1 13  ? 26.36684 -7.57363  15.94635 1.000 5.16970   ? 10  LEU A H    1 
ATOM   140  H HA   . LEU A 1 13  ? 27.98188 -7.99290  18.12252 1.000 10.56566  ? 10  LEU A HA   1 
ATOM   141  H HB2  . LEU A 1 13  ? 27.31287 -5.78989  18.04173 1.000 13.52488  ? 10  LEU A HB2  1 
ATOM   142  H HB3  . LEU A 1 13  ? 25.79524 -6.23869  17.89751 1.000 13.52488  ? 10  LEU A HB3  1 
ATOM   143  H HG   . LEU A 1 13  ? 25.70383 -6.84983  20.06879 1.000 19.54522  ? 10  LEU A HG   1 
ATOM   144  H HD11 . LEU A 1 13  ? 27.66279 -6.57727  21.45227 1.000 14.02056  ? 10  LEU A HD11 1 
ATOM   145  H HD12 . LEU A 1 13  ? 27.86401 -7.69801  20.34458 1.000 14.02056  ? 10  LEU A HD12 1 
ATOM   146  H HD13 . LEU A 1 13  ? 28.48505 -6.25130  20.13275 1.000 14.02056  ? 10  LEU A HD13 1 
ATOM   147  H HD21 . LEU A 1 13  ? 25.97475 -4.88240  21.23359 1.000 17.32648  ? 10  LEU A HD21 1 
ATOM   148  H HD22 . LEU A 1 13  ? 26.86981 -4.29279  20.06111 1.000 17.32648  ? 10  LEU A HD22 1 
ATOM   149  H HD23 . LEU A 1 13  ? 25.32668 -4.57890  19.81535 1.000 17.32648  ? 10  LEU A HD23 1 
ATOM   150  N N    . ALA A 1 14  ? 26.68260 -9.86562  18.93053 1.000 9.75752   ? 11  ALA A N    1 
ATOM   151  C CA   . ALA A 1 14  ? 25.88119 -10.96840 19.45919 1.000 11.93260  ? 11  ALA A CA   1 
ATOM   152  C C    . ALA A 1 14  ? 25.98590 -11.06395 20.97810 1.000 12.84526  ? 11  ALA A C    1 
ATOM   153  O O    . ALA A 1 14  ? 26.97281 -10.60612 21.58762 1.000 7.61294   ? 11  ALA A O    1 
ATOM   154  C CB   . ALA A 1 14  ? 26.33265 -12.29102 18.83342 1.000 13.54377  ? 11  ALA A CB   1 
ATOM   155  H H    . ALA A 1 14  ? 27.51930 -9.92402  19.12061 1.000 11.70904  ? 11  ALA A H    1 
ATOM   156  H HA   . ALA A 1 14  ? 24.94786 -10.80474 19.25183 1.000 14.31914  ? 11  ALA A HA   1 
ATOM   157  H HB1  . ALA A 1 14  ? 25.78861 -13.01082 19.18952 1.000 16.25254  ? 11  ALA A HB1  1 
ATOM   158  H HB2  . ALA A 1 14  ? 26.22321 -12.23866 17.87104 1.000 16.25254  ? 11  ALA A HB2  1 
ATOM   159  H HB3  . ALA A 1 14  ? 27.26546 -12.44190 19.05253 1.000 16.25254  ? 11  ALA A HB3  1 
ATOM   160  N N    . LYS A 1 15  ? 24.96563 -11.66665 21.58815 1.000 10.73018  ? 12  LYS A N    1 
ATOM   161  C CA   . LYS A 1 15  ? 25.01128 -11.92971 23.01749 1.000 7.50289   ? 12  LYS A CA   1 
ATOM   162  C C    . LYS A 1 15  ? 26.32875 -12.61016 23.35905 1.000 11.81940  ? 12  LYS A C    1 
ATOM   163  O O    . LYS A 1 15  ? 26.80116 -13.50972 22.66240 1.000 12.32611  ? 12  LYS A O    1 
ATOM   164  C CB   . LYS A 1 15  ? 23.82026 -12.80856 23.49074 1.000 6.30422   ? 12  LYS A CB   1 
ATOM   165  C CG   . LYS A 1 15  ? 23.87185 -13.13742 25.01313 1.000 17.43384  ? 12  LYS A CG   1 
ATOM   166  C CD   . LYS A 1 15  ? 22.55545 -13.71286 25.57740 1.000 38.48594  ? 12  LYS A CD   1 
ATOM   167  C CE   . LYS A 1 15  ? 22.28887 -13.27673 27.05836 1.000 40.17558  ? 12  LYS A CE   1 
ATOM   168  N NZ   . LYS A 1 15  ? 23.46437 -13.57547 27.95178 1.000 47.67269  ? 12  LYS A NZ   1 
ATOM   169  H H    . LYS A 1 15  ? 24.24530 -11.92877 21.19824 1.000 12.87623  ? 12  LYS A H    1 
ATOM   170  H HA   . LYS A 1 15  ? 24.93703 -11.08809 23.49401 1.000 9.00348   ? 12  LYS A HA   1 
ATOM   171  H HB2  . LYS A 1 15  ? 22.99145 -12.33637 23.31460 1.000 7.56508   ? 12  LYS A HB2  1 
ATOM   172  H HB3  . LYS A 1 15  ? 23.83461 -13.64685 23.00294 1.000 7.56508   ? 12  LYS A HB3  1 
ATOM   173  H HG2  . LYS A 1 15  ? 24.56929 -13.79387 25.16657 1.000 20.92063  ? 12  LYS A HG2  1 
ATOM   174  H HG3  . LYS A 1 15  ? 24.06973 -12.32288 25.50126 1.000 20.92063  ? 12  LYS A HG3  1 
ATOM   175  H HD2  . LYS A 1 15  ? 21.81487 -13.39949 25.03496 1.000 46.18314  ? 12  LYS A HD2  1 
ATOM   176  H HD3  . LYS A 1 15  ? 22.59760 -14.68165 25.55344 1.000 46.18314  ? 12  LYS A HD3  1 
ATOM   177  H HE2  . LYS A 1 15  ? 22.12232 -12.32152 27.08526 1.000 48.21071  ? 12  LYS A HE2  1 
ATOM   178  H HE3  . LYS A 1 15  ? 21.51856 -13.75754 27.39947 1.000 48.21071  ? 12  LYS A HE3  1 
ATOM   179  H HZ1  . LYS A 1 15  ? 24.05092 -12.90701 27.91680 1.000 57.20724  ? 12  LYS A HZ1  1 
ATOM   180  H HZ2  . LYS A 1 15  ? 23.19006 -13.67533 28.79255 1.000 57.20724  ? 12  LYS A HZ2  1 
ATOM   181  H HZ3  . LYS A 1 15  ? 23.86471 -14.32516 27.68761 1.000 57.20724  ? 12  LYS A HZ3  1 
ATOM   182  N N    . GLY A 1 16  ? 26.94665 -12.11635 24.41730 1.000 12.87280  ? 13  GLY A N    1 
ATOM   183  C CA   . GLY A 1 16  ? 28.18952 -12.66216 24.88290 1.000 9.20045   ? 13  GLY A CA   1 
ATOM   184  C C    . GLY A 1 16  ? 29.44513 -12.08585 24.25836 1.000 2.94877   ? 13  GLY A C    1 
ATOM   185  O O    . GLY A 1 16  ? 30.54319 -12.56408 24.56154 1.000 6.20622   ? 13  GLY A O    1 
ATOM   186  H H    . GLY A 1 16  ? 26.65570 -11.45545 24.88438 1.000 15.44738  ? 13  GLY A H    1 
ATOM   187  H HA2  . GLY A 1 16  ? 28.24789 -12.51679 25.84017 1.000 11.04056  ? 13  GLY A HA2  1 
ATOM   188  H HA3  . GLY A 1 16  ? 28.18928 -13.61623 24.70780 1.000 11.04056  ? 13  GLY A HA3  1 
ATOM   189  N N    . ALA A 1 17  ? 29.33850 -11.10689 23.35189 1.000 7.35987   ? 14  ALA A N    1 
ATOM   190  C CA   . ALA A 1 17  ? 30.51402 -10.40792 22.80521 1.000 8.07426   ? 14  ALA A CA   1 
ATOM   191  C C    . ALA A 1 17  ? 31.32518 -9.67436  23.89073 1.000 8.54120   ? 14  ALA A C    1 
ATOM   192  O O    . ALA A 1 17  ? 30.78523 -9.26787  24.92135 1.000 5.89758   ? 14  ALA A O    1 
ATOM   193  C CB   . ALA A 1 17  ? 30.05762 -9.40132  21.74626 1.000 2.36341   ? 14  ALA A CB   1 
ATOM   194  H H    . ALA A 1 17  ? 28.59184 -10.82397 23.03242 1.000 8.83186   ? 14  ALA A H    1 
ATOM   195  H HA   . ALA A 1 17  ? 31.10473 -11.06607 22.40670 1.000 9.68913   ? 14  ALA A HA   1 
ATOM   196  H HB1  . ALA A 1 17  ? 30.83704 -8.96236  21.37112 1.000 2.83610   ? 14  ALA A HB1  1 
ATOM   197  H HB2  . ALA A 1 17  ? 29.57601 -9.87312  21.04887 1.000 2.83610   ? 14  ALA A HB2  1 
ATOM   198  H HB3  . ALA A 1 17  ? 29.47733 -8.74543  22.16336 1.000 2.83610   ? 14  ALA A HB3  1 
ATOM   199  N N    . GLU A 1 18  ? 32.64610 -9.53608  23.66619 1.000 2.61005   ? 15  GLU A N    1 
ATOM   200  C CA   . GLU A 1 18  ? 33.53562 -8.83634  24.59063 1.000 3.90543   ? 15  GLU A CA   1 
ATOM   201  C C    . GLU A 1 18  ? 33.23239 -7.35291  24.36242 1.000 2.49439   ? 15  GLU A C    1 
ATOM   202  O O    . GLU A 1 18  ? 33.45354 -6.85287  23.26944 1.000 2.96297   ? 15  GLU A O    1 
ATOM   203  C CB   . GLU A 1 18  ? 35.01801 -9.20081  24.36725 1.000 3.96990   ? 15  GLU A CB   1 
ATOM   204  C CG   . GLU A 1 18  ? 35.70403 -9.36119  25.71607 1.000 8.38246   ? 15  GLU A CG   1 
ATOM   205  C CD   . GLU A 1 18  ? 35.63217 -8.03334  26.52854 1.000 5.32554   ? 15  GLU A CD   1 
ATOM   206  O OE1  . GLU A 1 18  ? 35.56483 -6.97086  25.88686 1.000 1.01229   ? 15  GLU A OE1  1 
ATOM   207  O OE2  . GLU A 1 18  ? 35.71728 -8.05077  27.80149 1.000 4.12541   ? 15  GLU A OE2  1 
ATOM   208  H H    . GLU A 1 18  ? 33.04939 -9.84622  22.97282 1.000 3.13207   ? 15  GLU A H    1 
ATOM   209  H HA   . GLU A 1 18  ? 33.36895 -9.08373  25.51363 1.000 4.68653   ? 15  GLU A HA   1 
ATOM   210  H HB2  . GLU A 1 18  ? 35.08141 -10.03722 23.88011 1.000 4.76390   ? 15  GLU A HB2  1 
ATOM   211  H HB3  . GLU A 1 18  ? 35.45957 -8.49374  23.87130 1.000 4.76390   ? 15  GLU A HB3  1 
ATOM   212  H HG2  . GLU A 1 18  ? 35.26139 -10.05884 26.22426 1.000 10.05897  ? 15  GLU A HG2  1 
ATOM   213  H HG3  . GLU A 1 18  ? 36.63673 -9.59048  25.58044 1.000 10.05897  ? 15  GLU A HG3  1 
ATOM   214  N N    . GLU A 1 19  ? 32.63334 -6.64147  25.35663 1.000 2.23601   ? 16  GLU A N    1 
ATOM   215  C CA   . GLU A 1 19  ? 32.16777 -5.25707  25.07257 1.000 1.79433   ? 16  GLU A CA   1 
ATOM   216  C C    . GLU A 1 19  ? 33.30191 -4.28533  24.76798 1.000 6.05825   ? 16  GLU A C    1 
ATOM   217  O O    . GLU A 1 19  ? 33.12378 -3.32079  24.02083 1.000 2.90421   ? 16  GLU A O    1 
ATOM   218  C CB   . GLU A 1 19  ? 31.37733 -4.70684  26.26272 1.000 3.17227   ? 16  GLU A CB   1 
ATOM   219  C CG   . GLU A 1 19  ? 31.96093 -5.05765  27.59625 1.000 5.66753   ? 16  GLU A CG   1 
ATOM   220  C CD   . GLU A 1 19  ? 31.33216 -6.36054  28.12317 1.000 6.34273   ? 16  GLU A CD   1 
ATOM   221  O OE1  . GLU A 1 19  ? 31.70353 -7.46101  27.66458 1.000 2.20429   ? 16  GLU A OE1  1 
ATOM   222  O OE2  . GLU A 1 19  ? 30.43967 -6.31398  29.01585 1.000 5.56749   ? 16  GLU A OE2  1 
ATOM   223  H H    . GLU A 1 19  ? 32.49324 -6.92217  26.15737 1.000 2.68323   ? 16  GLU A H    1 
ATOM   224  H HA   . GLU A 1 19  ? 31.59619 -5.31346  24.29090 1.000 2.15321   ? 16  GLU A HA   1 
ATOM   225  H HB2  . GLU A 1 19  ? 31.35068 -3.73939  26.19758 1.000 3.80673   ? 16  GLU A HB2  1 
ATOM   226  H HB3  . GLU A 1 19  ? 30.47700 -5.06641  26.23084 1.000 3.80673   ? 16  GLU A HB3  1 
ATOM   227  H HG2  . GLU A 1 19  ? 32.91831 -5.18721  27.50944 1.000 6.80105   ? 16  GLU A HG2  1 
ATOM   228  H HG3  . GLU A 1 19  ? 31.77854 -4.34593  28.22957 1.000 6.80105   ? 16  GLU A HG3  1 
ATOM   229  N N    . MET A 1 20  ? 34.46819 -4.49064  25.35996 1.000 3.90681   ? 17  MET A N    1 
ATOM   230  C CA   . MET A 1 20  ? 35.58912 -3.60886  25.06386 1.000 1.37135   ? 17  MET A CA   1 
ATOM   231  C C    . MET A 1 20  ? 36.00505 -3.77654  23.61165 1.000 2.59121   ? 17  MET A C    1 
ATOM   232  O O    . MET A 1 20  ? 36.37053 -2.80388  22.92371 1.000 1.70709   ? 17  MET A O    1 
ATOM   233  C CB   . MET A 1 20  ? 36.75770 -3.92006  25.99232 1.000 1.08659   ? 17  MET A CB   1 
ATOM   234  C CG   . MET A 1 20  ? 36.48401 -3.64782  27.47759 1.000 4.02495   ? 17  MET A CG   1 
ATOM   235  S SD   . MET A 1 20  ? 37.97316 -3.86209  28.43812 1.000 6.80657   ? 17  MET A SD   1 
ATOM   236  C CE   . MET A 1 20  ? 38.15121 -5.65137  28.60935 1.000 8.69738   ? 17  MET A CE   1 
ATOM   237  H H    . MET A 1 20  ? 34.63559 -5.11782  25.92408 1.000 4.68819   ? 17  MET A H    1 
ATOM   238  H HA   . MET A 1 20  ? 35.32831 -2.68868  25.22555 1.000 1.64563   ? 17  MET A HA   1 
ATOM   239  H HB2  . MET A 1 20  ? 36.98047 -4.85994  25.90345 1.000 1.30393   ? 17  MET A HB2  1 
ATOM   240  H HB3  . MET A 1 20  ? 37.51462 -3.37341  25.72940 1.000 1.30393   ? 17  MET A HB3  1 
ATOM   241  H HG2  . MET A 1 20  ? 36.17295 -2.73576  27.58846 1.000 4.82996   ? 17  MET A HG2  1 
ATOM   242  H HG3  . MET A 1 20  ? 35.81380 -4.26883  27.80328 1.000 4.82996   ? 17  MET A HG3  1 
ATOM   243  H HE1  . MET A 1 20  ? 37.84728 -5.91597  29.49168 1.000 10.43687  ? 17  MET A HE1  1 
ATOM   244  H HE2  . MET A 1 20  ? 37.61465 -6.08859  27.92976 1.000 10.43687  ? 17  MET A HE2  1 
ATOM   245  H HE3  . MET A 1 20  ? 39.08509 -5.88804  28.49641 1.000 10.43687  ? 17  MET A HE3  1 
ATOM   246  N N    . GLU A 1 21  ? 35.94520 -5.00754  23.12299 1.000 6.75938   ? 18  GLU A N    1 
ATOM   247  C CA   . GLU A 1 21  ? 36.40158 -5.30168  21.77869 1.000 4.54051   ? 18  GLU A CA   1 
ATOM   248  C C    . GLU A 1 21  ? 35.39543 -4.83774  20.72391 1.000 8.27772   ? 18  GLU A C    1 
ATOM   249  O O    . GLU A 1 21  ? 35.69553 -4.84430  19.53426 1.000 6.29698   ? 18  GLU A O    1 
ATOM   250  C CB   . GLU A 1 21  ? 36.62830 -6.81527  21.63491 1.000 6.98548   ? 18  GLU A CB   1 
ATOM   251  C CG   . GLU A 1 21  ? 37.82969 -7.38545  22.45254 1.000 6.61587   ? 18  GLU A CG   1 
ATOM   252  C CD   . GLU A 1 21  ? 37.84294 -8.92662  22.46894 1.000 8.75892   ? 18  GLU A CD   1 
ATOM   253  O OE1  . GLU A 1 21  ? 37.19116 -9.50366  21.56657 1.000 4.59479   ? 18  GLU A OE1  1 
ATOM   254  O OE2  . GLU A 1 21  ? 38.48402 -9.50919  23.38340 1.000 7.71197   ? 18  GLU A OE2  1 
ATOM   255  H H    . GLU A 1 21  ? 35.64379 -5.68924  23.55199 1.000 8.11127   ? 18  GLU A H    1 
ATOM   256  H HA   . GLU A 1 21  ? 37.24570 -4.85160  21.61809 1.000 5.44862   ? 18  GLU A HA   1 
ATOM   257  H HB2  . GLU A 1 21  ? 35.82857 -7.27493  21.93497 1.000 8.38259   ? 18  GLU A HB2  1 
ATOM   258  H HB3  . GLU A 1 21  ? 36.79350 -7.01305  20.69977 1.000 8.38259   ? 18  GLU A HB3  1 
ATOM   259  H HG2  . GLU A 1 21  ? 38.65958 -7.08012  22.05386 1.000 7.93906   ? 18  GLU A HG2  1 
ATOM   260  H HG3  . GLU A 1 21  ? 37.76753 -7.07380  23.36901 1.000 7.93906   ? 18  GLU A HG3  1 
ATOM   261  N N    . THR A 1 22  ? 34.19866 -4.50925  21.17159 1.000 6.36726   ? 19  THR A N    1 
ATOM   262  C CA   . THR A 1 22  ? 33.14201 -3.94554  20.35510 1.000 2.57174   ? 19  THR A CA   1 
ATOM   263  C C    . THR A 1 22  ? 33.24856 -2.41499  20.33973 1.000 4.23158   ? 19  THR A C    1 
ATOM   264  O O    . THR A 1 22  ? 33.31287 -1.81673  19.26336 1.000 4.95660   ? 19  THR A O    1 
ATOM   265  C CB   . THR A 1 22  ? 31.79147 -4.44149  20.91134 1.000 8.08117   ? 19  THR A CB   1 
ATOM   266  O OG1  . THR A 1 22  ? 31.76846 -5.87917  20.86393 1.000 9.67547   ? 19  THR A OG1  1 
ATOM   267  C CG2  . THR A 1 22  ? 30.63711 -3.92061  20.10419 1.000 14.17045  ? 19  THR A CG2  1 
ATOM   268  H H    . THR A 1 22  ? 33.95930 -4.60853  21.99162 1.000 7.64072   ? 19  THR A H    1 
ATOM   269  H HA   . THR A 1 22  ? 33.19591 -4.24169  19.43299 1.000 3.08611   ? 19  THR A HA   1 
ATOM   270  H HB   . THR A 1 22  ? 31.68945 -4.12350  21.82204 1.000 9.69742   ? 19  THR A HB   1 
ATOM   271  H HG1  . THR A 1 22  ? 32.40084 -6.19182  21.31995 1.000 11.61058  ? 19  THR A HG1  1 
ATOM   272  H HG21 . THR A 1 22  ? 29.81942 -4.37287  20.36449 1.000 17.00455  ? 19  THR A HG21 1 
ATOM   273  H HG22 . THR A 1 22  ? 30.53112 -2.96801  20.25325 1.000 17.00455  ? 19  THR A HG22 1 
ATOM   274  H HG23 . THR A 1 22  ? 30.79575 -4.07575  19.15991 1.000 17.00455  ? 19  THR A HG23 1 
ATOM   275  N N    . VAL A 1 23  ? 33.33909 -1.78075  21.54313 1.000 3.88823   ? 20  VAL A N    1 
ATOM   276  C CA   . VAL A 1 23  ? 33.22804 -0.30872  21.63473 1.000 4.64100   ? 20  VAL A CA   1 
ATOM   277  C C    . VAL A 1 23  ? 34.46452 0.36681   21.13073 1.000 2.33607   ? 20  VAL A C    1 
ATOM   278  O O    . VAL A 1 23  ? 34.40042 1.43239   20.48569 1.000 3.79085   ? 20  VAL A O    1 
ATOM   279  C CB   . VAL A 1 23  ? 32.92768 0.07886   23.11266 1.000 3.34903   ? 20  VAL A CB   1 
ATOM   280  C CG1  . VAL A 1 23  ? 33.01571 1.59345   23.32052 1.000 8.30190   ? 20  VAL A CG1  1 
ATOM   281  C CG2  . VAL A 1 23  ? 31.54789 -0.45487  23.37724 1.000 5.16914   ? 20  VAL A CG2  1 
ATOM   282  H H    . VAL A 1 23  ? 33.46144 -2.17521  22.29747 1.000 4.66590   ? 20  VAL A H    1 
ATOM   283  H HA   . VAL A 1 23  ? 32.49791 -0.01396  21.06821 1.000 5.56921   ? 20  VAL A HA   1 
ATOM   284  H HB   . VAL A 1 23  ? 33.57230 -0.29195  23.73545 1.000 4.01885   ? 20  VAL A HB   1 
ATOM   285  H HG11 . VAL A 1 23  ? 33.94946 1.85235   23.36508 1.000 9.96230   ? 20  VAL A HG11 1 
ATOM   286  H HG12 . VAL A 1 23  ? 32.58380 2.04007   22.57562 1.000 9.96230   ? 20  VAL A HG12 1 
ATOM   287  H HG13 . VAL A 1 23  ? 32.56834 1.82498   24.14947 1.000 9.96230   ? 20  VAL A HG13 1 
ATOM   288  H HG21 . VAL A 1 23  ? 31.22341 -0.08985  24.21531 1.000 6.20298   ? 20  VAL A HG21 1 
ATOM   289  H HG22 . VAL A 1 23  ? 30.96182 -0.18874  22.65157 1.000 6.20298   ? 20  VAL A HG22 1 
ATOM   290  H HG23 . VAL A 1 23  ? 31.58864 -1.42249  23.43161 1.000 6.20298   ? 20  VAL A HG23 1 
ATOM   291  N N    . ILE A 1 24  ? 35.62420 -0.25505  21.34299 1.000 0.00008   ? 21  ILE A N    1 
ATOM   292  C CA   . ILE A 1 24  ? 36.84049 0.43748   20.97513 1.000 0.00008   ? 21  ILE A CA   1 
ATOM   293  C C    . ILE A 1 24  ? 36.93007 0.58433   19.47236 1.000 0.17040   ? 21  ILE A C    1 
ATOM   294  O O    . ILE A 1 24  ? 37.19825 1.70058   18.98649 1.000 5.94810   ? 21  ILE A O    1 
ATOM   295  C CB   . ILE A 1 24  ? 38.05160 -0.34999  21.56075 1.000 1.79214   ? 21  ILE A CB   1 
ATOM   296  C CG1  . ILE A 1 24  ? 38.11867 -0.13869  23.05708 1.000 6.40356   ? 21  ILE A CG1  1 
ATOM   297  C CG2  . ILE A 1 24  ? 39.26793 0.23921   20.93403 1.000 2.45330   ? 21  ILE A CG2  1 
ATOM   298  C CD1  . ILE A 1 24  ? 39.23650 -0.92084  23.71708 1.000 4.67948   ? 21  ILE A CD1  1 
ATOM   299  H H    . ILE A 1 24  ? 35.72217 -1.03923  21.68220 1.000 0.00008   ? 21  ILE A H    1 
ATOM   300  H HA   . ILE A 1 24  ? 36.83411 1.32488   21.36676 1.000 0.00008   ? 21  ILE A HA   1 
ATOM   301  H HB   . ILE A 1 24  ? 37.97232 -1.30047  21.38408 1.000 2.15059   ? 21  ILE A HB   1 
ATOM   302  H HG12 . ILE A 1 24  ? 38.26683 0.80318   23.23552 1.000 7.68429   ? 21  ILE A HG12 1 
ATOM   303  H HG13 . ILE A 1 24  ? 37.28017 -0.42346  23.45296 1.000 7.68429   ? 21  ILE A HG13 1 
ATOM   304  H HG21 . ILE A 1 24  ? 40.05401 -0.10029  21.38978 1.000 2.94398   ? 21  ILE A HG21 1 
ATOM   305  H HG22 . ILE A 1 24  ? 39.29406 -0.01234  19.99757 1.000 2.94398   ? 21  ILE A HG22 1 
ATOM   306  H HG23 . ILE A 1 24  ? 39.22922 1.20495   21.01616 1.000 2.94398   ? 21  ILE A HG23 1 
ATOM   307  H HD11 . ILE A 1 24  ? 39.08091 -0.94752  24.67415 1.000 5.61539   ? 21  ILE A HD11 1 
ATOM   308  H HD12 . ILE A 1 24  ? 39.24600 -1.82198  23.35825 1.000 5.61539   ? 21  ILE A HD12 1 
ATOM   309  H HD13 . ILE A 1 24  ? 40.08137 -0.48195  23.53142 1.000 5.61539   ? 21  ILE A HD13 1 
ATOM   310  N N    . PRO A 1 25  ? 36.74941 -0.43916  18.65601 1.000 0.00008   ? 22  PRO A N    1 
ATOM   311  C CA   . PRO A 1 25  ? 36.80406 -0.25027  17.20644 1.000 3.23359   ? 22  PRO A CA   1 
ATOM   312  C C    . PRO A 1 25  ? 35.69868 0.65715   16.68274 1.000 3.40836   ? 22  PRO A C    1 
ATOM   313  O O    . PRO A 1 25  ? 35.88494 1.40220   15.70679 1.000 5.81889   ? 22  PRO A O    1 
ATOM   314  C CB   . PRO A 1 25  ? 36.65793 -1.66788  16.68376 1.000 4.12376   ? 22  PRO A CB   1 
ATOM   315  C CG   . PRO A 1 25  ? 37.05430 -2.59303  17.81877 1.000 7.53294   ? 22  PRO A CG   1 
ATOM   316  C CD   . PRO A 1 25  ? 36.62283 -1.83936  19.06799 1.000 2.08718   ? 22  PRO A CD   1 
ATOM   317  H HA   . PRO A 1 25  ? 37.66588 0.11095   16.94627 1.000 3.88032   ? 22  PRO A HA   1 
ATOM   318  H HB2  . PRO A 1 25  ? 35.73655 -1.82305  16.42323 1.000 4.94852   ? 22  PRO A HB2  1 
ATOM   319  H HB3  . PRO A 1 25  ? 37.24398 -1.79329  15.92106 1.000 4.94852   ? 22  PRO A HB3  1 
ATOM   320  H HG2  . PRO A 1 25  ? 36.58710 -3.43949  17.74045 1.000 9.03954   ? 22  PRO A HG2  1 
ATOM   321  H HG3  . PRO A 1 25  ? 38.01288 -2.74127  17.81166 1.000 9.03954   ? 22  PRO A HG3  1 
ATOM   322  H HD2  . PRO A 1 25  ? 35.70588 -2.05135  19.30287 1.000 2.50463   ? 22  PRO A HD2  1 
ATOM   323  H HD3  . PRO A 1 25  ? 37.21056 -2.03701  19.81392 1.000 2.50463   ? 22  PRO A HD3  1 
ATOM   324  N N    . VAL A 1 26  ? 34.50484 0.51145   17.21743 1.000 1.65764   ? 23  VAL A N    1 
ATOM   325  C CA   . VAL A 1 26  ? 33.41478 1.36897   16.78146 1.000 0.36936   ? 23  VAL A CA   1 
ATOM   326  C C    . VAL A 1 26  ? 33.75587 2.82659   16.99953 1.000 2.91138   ? 23  VAL A C    1 
ATOM   327  O O    . VAL A 1 26  ? 33.56939 3.68177   16.10540 1.000 6.34903   ? 23  VAL A O    1 
ATOM   328  C CB   . VAL A 1 26  ? 32.12409 0.97574   17.49052 1.000 0.00008   ? 23  VAL A CB   1 
ATOM   329  C CG1  . VAL A 1 26  ? 31.11067 2.04009   17.29493 1.000 3.20353   ? 23  VAL A CG1  1 
ATOM   330  C CG2  . VAL A 1 26  ? 31.57203 -0.29530  16.92202 1.000 3.62962   ? 23  VAL A CG2  1 
ATOM   331  H H    . VAL A 1 26  ? 34.29854 -0.06352  17.82279 1.000 1.98918   ? 23  VAL A H    1 
ATOM   332  H HA   . VAL A 1 26  ? 33.28653 1.24374   15.82816 1.000 0.44325   ? 23  VAL A HA   1 
ATOM   333  H HB   . VAL A 1 26  ? 32.31608 0.85158   18.43319 1.000 0.00008   ? 23  VAL A HB   1 
ATOM   334  H HG11 . VAL A 1 26  ? 30.22686 1.66265   17.42656 1.000 3.84425   ? 23  VAL A HG11 1 
ATOM   335  H HG12 . VAL A 1 26  ? 31.26749 2.74776   17.93952 1.000 3.84425   ? 23  VAL A HG12 1 
ATOM   336  H HG13 . VAL A 1 26  ? 31.19007 2.38997   16.39372 1.000 3.84425   ? 23  VAL A HG13 1 
ATOM   337  H HG21 . VAL A 1 26  ? 30.75648 -0.52455  17.39450 1.000 4.35556   ? 23  VAL A HG21 1 
ATOM   338  H HG22 . VAL A 1 26  ? 31.38263 -0.16377  15.97983 1.000 4.35556   ? 23  VAL A HG22 1 
ATOM   339  H HG23 . VAL A 1 26  ? 32.22778 -1.00153  17.03215 1.000 4.35556   ? 23  VAL A HG23 1 
ATOM   340  N N    . ASP A 1 27  ? 34.16550 3.16093   18.21295 1.000 1.86275   ? 24  ASP A N    1 
ATOM   341  C CA   . ASP A 1 27  ? 34.55828 4.52968   18.54833 1.000 1.85917   ? 24  ASP A CA   1 
ATOM   342  C C    . ASP A 1 27  ? 35.70634 5.01047   17.67097 1.000 4.03126   ? 24  ASP A C    1 
ATOM   343  O O    . ASP A 1 27  ? 35.60773 6.05420   17.02853 1.000 2.99821   ? 24  ASP A O    1 
ATOM   344  C CB   . ASP A 1 27  ? 34.87514 4.52337   20.05382 1.000 3.15162   ? 24  ASP A CB   1 
ATOM   345  C CG   . ASP A 1 27  ? 35.14460 5.87254   20.64400 1.000 7.00978   ? 24  ASP A CG   1 
ATOM   346  O OD1  . ASP A 1 27  ? 35.81653 6.68674   19.96926 1.000 4.88769   ? 24  ASP A OD1  1 
ATOM   347  O OD2  . ASP A 1 27  ? 34.85302 6.07305   21.84824 1.000 5.00415   ? 24  ASP A OD2  1 
ATOM   348  H H    . ASP A 1 27  ? 34.22799 2.61206   18.87207 1.000 2.23531   ? 24  ASP A H    1 
ATOM   349  H HA   . ASP A 1 27  ? 33.85013 5.17167   18.38321 1.000 2.23102   ? 24  ASP A HA   1 
ATOM   350  H HB2  . ASP A 1 27  ? 34.11764 4.14458   20.52670 1.000 3.78196   ? 24  ASP A HB2  1 
ATOM   351  H HB3  . ASP A 1 27  ? 35.66406 3.97840   20.20053 1.000 3.78196   ? 24  ASP A HB3  1 
ATOM   352  N N    . VAL A 1 28  ? 36.79172 4.24911   17.58485 1.000 4.20989   ? 25  VAL A N    1 
ATOM   353  C CA   . VAL A 1 28  ? 37.92031 4.69757   16.79317 1.000 4.39410   ? 25  VAL A CA   1 
ATOM   354  C C    . VAL A 1 28  ? 37.53921 4.83674   15.33508 1.000 10.88348  ? 25  VAL A C    1 
ATOM   355  O O    . VAL A 1 28  ? 38.01104 5.74315   14.65043 1.000 6.84188   ? 25  VAL A O    1 
ATOM   356  C CB   . VAL A 1 28  ? 39.11040 3.70420   16.95833 1.000 3.05929   ? 25  VAL A CB   1 
ATOM   357  C CG1  . VAL A 1 28  ? 40.17610 4.06538   15.97963 1.000 10.28282  ? 25  VAL A CG1  1 
ATOM   358  C CG2  . VAL A 1 28  ? 39.54350 3.81495   18.39387 1.000 5.02554   ? 25  VAL A CG2  1 
ATOM   359  H H    . VAL A 1 28  ? 36.89450 3.48602   17.96791 1.000 5.05188   ? 25  VAL A H    1 
ATOM   360  H HA   . VAL A 1 28  ? 38.18794 5.57151   17.11796 1.000 5.27294   ? 25  VAL A HA   1 
ATOM   361  H HB   . VAL A 1 28  ? 38.88429 2.77931   16.77299 1.000 3.67116   ? 25  VAL A HB   1 
ATOM   362  H HG11 . VAL A 1 28  ? 41.00637 3.64014   16.24557 1.000 12.33940  ? 25  VAL A HG11 1 
ATOM   363  H HG12 . VAL A 1 28  ? 39.91358 3.75626   15.09848 1.000 12.33940  ? 25  VAL A HG12 1 
ATOM   364  H HG13 . VAL A 1 28  ? 40.28538 5.02918   15.97309 1.000 12.33940  ? 25  VAL A HG13 1 
ATOM   365  H HG21 . VAL A 1 28  ? 40.28519 3.20901   18.54761 1.000 6.03066   ? 25  VAL A HG21 1 
ATOM   366  H HG22 . VAL A 1 28  ? 39.81995 4.72773   18.57080 1.000 6.03066   ? 25  VAL A HG22 1 
ATOM   367  H HG23 . VAL A 1 28  ? 38.79827 3.57791   18.96775 1.000 6.03066   ? 25  VAL A HG23 1 
ATOM   368  N N    . MET A 1 29  ? 36.72490 3.92228   14.81635 1.000 2.84337   ? 26  MET A N    1 
ATOM   369  C CA   . MET A 1 29  ? 36.41761 4.02191   13.41103 1.000 5.65471   ? 26  MET A CA   1 
ATOM   370  C C    . MET A 1 29  ? 35.56699 5.24549   13.15076 1.000 6.77874   ? 26  MET A C    1 
ATOM   371  O O    . MET A 1 29  ? 35.74503 5.91671   12.11446 1.000 4.68214   ? 26  MET A O    1 
ATOM   372  C CB   . MET A 1 29  ? 35.71676 2.79244   12.86181 1.000 4.19356   ? 26  MET A CB   1 
ATOM   373  C CG   . MET A 1 29  ? 36.71713 1.69314   12.59081 1.000 9.32116   ? 26  MET A CG   1 
ATOM   374  S SD   . MET A 1 29  ? 35.79532 0.33490   11.77662 1.000 6.34108   ? 26  MET A SD   1 
ATOM   375  C CE   . MET A 1 29  ? 34.71492 -0.40918  12.98832 1.000 3.14696   ? 26  MET A CE   1 
ATOM   376  H H    . MET A 1 29  ? 36.35943 3.27003   15.24132 1.000 3.41206   ? 26  MET A H    1 
ATOM   377  H HA   . MET A 1 29  ? 37.26578 4.07443   12.94332 1.000 6.78567   ? 26  MET A HA   1 
ATOM   378  H HB2  . MET A 1 29  ? 35.07014 2.47084   13.50940 1.000 5.03229   ? 26  MET A HB2  1 
ATOM   379  H HB3  . MET A 1 29  ? 35.27014 3.01740   12.03065 1.000 5.03229   ? 26  MET A HB3  1 
ATOM   380  H HG2  . MET A 1 29  ? 37.41823 2.01039   12.00029 1.000 11.18541  ? 26  MET A HG2  1 
ATOM   381  H HG3  . MET A 1 29  ? 37.10257 1.37281   13.42130 1.000 11.18541  ? 26  MET A HG3  1 
ATOM   382  H HE1  . MET A 1 29  ? 34.28103 -1.18129  12.59273 1.000 3.77637   ? 26  MET A HE1  1 
ATOM   383  H HE2  . MET A 1 29  ? 35.24172 -0.68272  13.75549 1.000 3.77637   ? 26  MET A HE2  1 
ATOM   384  H HE3  . MET A 1 29  ? 34.04884 0.24172   13.25955 1.000 3.77637   ? 26  MET A HE3  1 
ATOM   385  N N    . ARG A 1 30  ? 34.68660 5.59008   14.09017 1.000 3.21319   ? 27  ARG A N    1 
ATOM   386  C CA   . ARG A 1 30  ? 33.90371 6.79754   13.87274 1.000 4.67221   ? 27  ARG A CA   1 
ATOM   387  C C    . ARG A 1 30  ? 34.75284 8.05778   14.01633 1.000 8.24746   ? 27  ARG A C    1 
ATOM   388  O O    . ARG A 1 30  ? 34.48939 9.05039   13.31560 1.000 4.95236   ? 27  ARG A O    1 
ATOM   389  C CB   . ARG A 1 30  ? 32.69546 6.84862   14.80826 1.000 5.04181   ? 27  ARG A CB   1 
ATOM   390  C CG   . ARG A 1 30  ? 31.66733 5.76157   14.45780 1.000 2.21843   ? 27  ARG A CG   1 
ATOM   391  C CD   . ARG A 1 30  ? 30.45793 5.75640   15.36380 1.000 6.49548   ? 27  ARG A CD   1 
ATOM   392  N NE   . ARG A 1 30  ? 29.32358 5.02417   14.80808 1.000 11.71632  ? 27  ARG A NE   1 
ATOM   393  C CZ   . ARG A 1 30  ? 28.42853 4.35307   15.53461 1.000 10.71040  ? 27  ARG A CZ   1 
ATOM   394  N NH1  . ARG A 1 30  ? 28.45924 4.36704   16.85656 1.000 5.74494   ? 27  ARG A NH1  1 
ATOM   395  N NH2  . ARG A 1 30  ? 27.51838 3.60741   14.91477 1.000 7.03185   ? 27  ARG A NH2  1 
ATOM   396  H H    . ARG A 1 30  ? 34.53374 5.16379   14.82127 1.000 3.85585   ? 27  ARG A H    1 
ATOM   397  H HA   . ARG A 1 30  ? 33.55853 6.77178   12.96660 1.000 5.60667   ? 27  ARG A HA   1 
ATOM   398  H HB2  . ARG A 1 30  ? 32.99068 6.70751   15.72141 1.000 6.05019   ? 27  ARG A HB2  1 
ATOM   399  H HB3  . ARG A 1 30  ? 32.26473 7.71411   14.72885 1.000 6.05019   ? 27  ARG A HB3  1 
ATOM   400  H HG2  . ARG A 1 30  ? 31.35640 5.90562   13.55034 1.000 2.66214   ? 27  ARG A HG2  1 
ATOM   401  H HG3  . ARG A 1 30  ? 32.09352 4.89309   14.52853 1.000 2.66214   ? 27  ARG A HG3  1 
ATOM   402  H HD2  . ARG A 1 30  ? 30.69786 5.33888   16.20583 1.000 7.79460   ? 27  ARG A HD2  1 
ATOM   403  H HD3  . ARG A 1 30  ? 30.17540 6.67178   15.51601 1.000 7.79460   ? 27  ARG A HD3  1 
ATOM   404  H HE   . ARG A 1 30  ? 29.22576 5.02564   13.95367 1.000 14.05960  ? 27  ARG A HE   1 
ATOM   405  H HH11 . ARG A 1 30  ? 29.06643 4.81622   17.26785 1.000 6.89394   ? 27  ARG A HH11 1 
ATOM   406  H HH12 . ARG A 1 30  ? 27.87203 3.92694   17.30500 1.000 6.89394   ? 27  ARG A HH12 1 
ATOM   407  H HH21 . ARG A 1 30  ? 27.51188 3.56232   14.05598 1.000 8.43823   ? 27  ARG A HH21 1 
ATOM   408  H HH22 . ARG A 1 30  ? 26.93630 3.17030   15.37273 1.000 8.43823   ? 27  ARG A HH22 1 
ATOM   409  N N    . ARG A 1 31  ? 35.75038 8.07716   14.88714 1.000 4.85287   ? 28  ARG A N    1 
ATOM   410  C CA   . ARG A 1 31  ? 36.68931 9.19287   14.88566 1.000 5.13269   ? 28  ARG A CA   1 
ATOM   411  C C    . ARG A 1 31  ? 37.38145 9.39105   13.56713 1.000 5.34294   ? 28  ARG A C    1 
ATOM   412  O O    . ARG A 1 31  ? 37.87351 10.49890  13.27042 1.000 6.45410   ? 28  ARG A O    1 
ATOM   413  C CB   . ARG A 1 31  ? 37.78159 8.96257   15.94809 1.000 6.35703   ? 28  ARG A CB   1 
ATOM   414  C CG   . ARG A 1 31  ? 37.28984 9.13852   17.34914 1.000 5.73215   ? 28  ARG A CG   1 
ATOM   415  C CD   . ARG A 1 31  ? 38.26106 8.62327   18.42764 1.000 3.30443   ? 28  ARG A CD   1 
ATOM   416  N NE   . ARG A 1 31  ? 37.77105 8.84621   19.78053 1.000 12.75545  ? 28  ARG A NE   1 
ATOM   417  C CZ   . ARG A 1 31  ? 38.21344 9.80071   20.60464 1.000 2.38971   ? 28  ARG A CZ   1 
ATOM   418  N NH1  . ARG A 1 31  ? 39.09865 10.69891  20.21057 1.000 6.37161   ? 28  ARG A NH1  1 
ATOM   419  N NH2  . ARG A 1 31  ? 37.70651 9.87526   21.82791 1.000 8.58012   ? 28  ARG A NH2  1 
ATOM   420  H H    . ARG A 1 31  ? 35.90530 7.47155   15.47776 1.000 5.82346   ? 28  ARG A H    1 
ATOM   421  H HA   . ARG A 1 31  ? 36.17270 9.98846   15.08825 1.000 6.15925   ? 28  ARG A HA   1 
ATOM   422  H HB2  . ARG A 1 31  ? 38.11729 8.05664   15.86149 1.000 7.62845   ? 28  ARG A HB2  1 
ATOM   423  H HB3  . ARG A 1 31  ? 38.49990 9.59791   15.80222 1.000 7.62845   ? 28  ARG A HB3  1 
ATOM   424  H HG2  . ARG A 1 31  ? 37.14541 10.08383  17.51171 1.000 6.87860   ? 28  ARG A HG2  1 
ATOM   425  H HG3  . ARG A 1 31  ? 36.45584 8.65344   17.44931 1.000 6.87860   ? 28  ARG A HG3  1 
ATOM   426  H HD2  . ARG A 1 31  ? 38.38850 7.66908   18.30854 1.000 3.96533   ? 28  ARG A HD2  1 
ATOM   427  H HD3  . ARG A 1 31  ? 39.10909 9.08520   18.33618 1.000 3.96533   ? 28  ARG A HD3  1 
ATOM   428  H HE   . ARG A 1 31  ? 37.15131 8.32527   20.07062 1.000 15.30656  ? 28  ARG A HE   1 
ATOM   429  H HH11 . ARG A 1 31  ? 39.40391 10.67795  19.40684 1.000 7.64594   ? 28  ARG A HH11 1 
ATOM   430  H HH12 . ARG A 1 31  ? 39.36957 11.30451  20.75778 1.000 7.64594   ? 28  ARG A HH12 1 
ATOM   431  H HH21 . ARG A 1 31  ? 37.10391 9.31520   22.07852 1.000 10.29615  ? 28  ARG A HH21 1 
ATOM   432  H HH22 . ARG A 1 31  ? 37.98039 10.48366  22.37053 1.000 10.29615  ? 28  ARG A HH22 1 
ATOM   433  N N    . ALA A 1 32  ? 37.55488 8.31309   12.80599 1.000 6.70458   ? 29  ALA A N    1 
ATOM   434  C CA   . ALA A 1 32  ? 38.20959 8.38081   11.48803 1.000 7.08515   ? 29  ALA A CA   1 
ATOM   435  C C    . ALA A 1 32  ? 37.23133 8.70960   10.38390 1.000 6.87193   ? 29  ALA A C    1 
ATOM   436  O O    . ALA A 1 32  ? 37.59501 8.73186   9.22005  1.000 12.94767  ? 29  ALA A O    1 
ATOM   437  C CB   . ALA A 1 32  ? 38.87615 7.03821   11.16442 1.000 6.07333   ? 29  ALA A CB   1 
ATOM   438  H H    . ALA A 1 32  ? 37.30182 7.52164   13.02771 1.000 8.04551   ? 29  ALA A H    1 
ATOM   439  H HA   . ALA A 1 32  ? 38.89413 9.06735   11.51914 1.000 8.50220   ? 29  ALA A HA   1 
ATOM   440  H HB1  . ALA A 1 32  ? 39.30311 7.09891   10.29556 1.000 7.28801   ? 29  ALA A HB1  1 
ATOM   441  H HB2  . ALA A 1 32  ? 39.53845 6.84217   11.84546 1.000 7.28801   ? 29  ALA A HB2  1 
ATOM   442  H HB3  . ALA A 1 32  ? 38.19869 6.34409   11.15231 1.000 7.28801   ? 29  ALA A HB3  1 
ATOM   443  N N    . GLY A 1 33  ? 35.98483 9.00382   10.73383 1.000 6.95608   ? 30  GLY A N    1 
ATOM   444  C CA   . GLY A 1 33  ? 35.08698 9.39878   9.67800  1.000 11.67351  ? 30  GLY A CA   1 
ATOM   445  C C    . GLY A 1 33  ? 34.40828 8.26628   8.94244  1.000 8.03032   ? 30  GLY A C    1 
ATOM   446  O O    . GLY A 1 33  ? 33.66672 8.52592   7.98804  1.000 9.53546   ? 30  GLY A O    1 
ATOM   447  H H    . GLY A 1 33  ? 35.66159 8.98133   11.53045 1.000 8.34732   ? 30  GLY A H    1 
ATOM   448  H HA2  . GLY A 1 33  ? 34.39239 9.95915   10.05804 1.000 14.00823  ? 30  GLY A HA2  1 
ATOM   449  H HA3  . GLY A 1 33  ? 35.58669 9.91403   9.02554  1.000 14.00823  ? 30  GLY A HA3  1 
ATOM   450  N N    . ILE A 1 34  ? 34.61213 7.01694   9.37391  1.000 10.24864  ? 31  ILE A N    1 
ATOM   451  C CA   . ILE A 1 34  ? 33.91659 5.85016   8.82244  1.000 9.69533   ? 31  ILE A CA   1 
ATOM   452  C C    . ILE A 1 34  ? 32.48691 5.78909   9.32324  1.000 17.53403  ? 31  ILE A C    1 
ATOM   453  O O    . ILE A 1 34  ? 32.20070 6.09566   10.49281 1.000 11.01977  ? 31  ILE A O    1 
ATOM   454  C CB   . ILE A 1 34  ? 34.72508 4.59086   9.20152  1.000 11.73621  ? 31  ILE A CB   1 
ATOM   455  C CG1  . ILE A 1 34  ? 36.14172 4.70240   8.63062  1.000 14.30601  ? 31  ILE A CG1  1 
ATOM   456  C CG2  . ILE A 1 34  ? 34.05924 3.31400   8.74657  1.000 17.70796  ? 31  ILE A CG2  1 
ATOM   457  C CD1  . ILE A 1 34  ? 37.19471 3.66706   9.20406  1.000 23.20260  ? 31  ILE A CD1  1 
ATOM   458  H H    . ILE A 1 34  ? 35.16322 6.81368   10.00208 1.000 12.29838  ? 31  ILE A H    1 
ATOM   459  H HA   . ILE A 1 34  ? 33.85505 5.92295   7.85714  1.000 11.63441  ? 31  ILE A HA   1 
ATOM   460  H HB   . ILE A 1 34  ? 34.76595 4.54865   10.16974 1.000 14.08347  ? 31  ILE A HB   1 
ATOM   461  H HG12 . ILE A 1 34  ? 36.09538 4.56485   7.67154  1.000 17.16723  ? 31  ILE A HG12 1 
ATOM   462  H HG13 . ILE A 1 34  ? 36.47831 5.59169   8.82235  1.000 17.16723  ? 31  ILE A HG13 1 
ATOM   463  H HG21 . ILE A 1 34  ? 34.65164 2.56735   8.92681  1.000 21.24957  ? 31  ILE A HG21 1 
ATOM   464  H HG22 . ILE A 1 34  ? 33.22742 3.20108   9.23260  1.000 21.24957  ? 31  ILE A HG22 1 
ATOM   465  H HG23 . ILE A 1 34  ? 33.88096 3.37255   7.79489  1.000 21.24957  ? 31  ILE A HG23 1 
ATOM   466  H HD11 . ILE A 1 34  ? 38.08231 3.92243   8.90767  1.000 27.84314  ? 31  ILE A HD11 1 
ATOM   467  H HD12 . ILE A 1 34  ? 37.15348 3.67864   10.17311 1.000 27.84314  ? 31  ILE A HD12 1 
ATOM   468  H HD13 . ILE A 1 34  ? 36.97808 2.78091   8.87434  1.000 27.84314  ? 31  ILE A HD13 1 
ATOM   469  N N    . LYS A 1 35  ? 31.55355 5.43888   8.40794  1.000 3.61557   ? 32  LYS A N    1 
ATOM   470  C CA   A LYS A 1 35  ? 30.16752 5.18919   8.75839  0.434 6.45745   ? 32  LYS A CA   1 
ATOM   471  C CA   B LYS A 1 35  ? 30.17118 5.18867   8.76699  0.566 6.37128   ? 32  LYS A CA   1 
ATOM   472  C C    . LYS A 1 35  ? 30.07587 3.75616   9.26460  1.000 12.18841  ? 32  LYS A C    1 
ATOM   473  O O    . LYS A 1 35  ? 30.21035 2.80477   8.48450  1.000 14.39900  ? 32  LYS A O    1 
ATOM   474  C CB   A LYS A 1 35  ? 29.24983 5.41172   7.55000  0.434 14.37269  ? 32  LYS A CB   1 
ATOM   475  C CB   B LYS A 1 35  ? 29.24712 5.41509   7.56470  0.566 14.39922  ? 32  LYS A CB   1 
ATOM   476  C CG   A LYS A 1 35  ? 29.02253 6.86372   7.18626  0.434 17.03923  ? 32  LYS A CG   1 
ATOM   477  C CG   B LYS A 1 35  ? 27.77219 5.39595   7.91070  0.566 17.49982  ? 32  LYS A CG   1 
ATOM   478  C CD   A LYS A 1 35  ? 27.57270 7.09710   6.77685  0.434 27.86030  ? 32  LYS A CD   1 
ATOM   479  C CD   B LYS A 1 35  ? 26.92309 5.69878   6.65158  0.566 22.67268  ? 32  LYS A CD   1 
ATOM   480  C CE   A LYS A 1 35  ? 27.45164 7.59677   5.32470  0.434 40.56921  ? 32  LYS A CE   1 
ATOM   481  C CE   B LYS A 1 35  ? 27.44132 6.90592   5.78079  0.566 44.08881  ? 32  LYS A CE   1 
ATOM   482  N NZ   A LYS A 1 35  ? 25.99744 7.67055   4.87704  0.434 42.99285  ? 32  LYS A NZ   1 
ATOM   483  N NZ   B LYS A 1 35  ? 26.55141 7.21628   4.56443  0.566 49.08894  ? 32  LYS A NZ   1 
ATOM   484  H H    A LYS A 1 35  ? 31.71710 5.34225   7.56918  0.434 4.33870   ? 32  LYS A H    1 
ATOM   485  H H    B LYS A 1 35  ? 31.71479 5.34321   7.56862  0.566 4.33870   ? 32  LYS A H    1 
ATOM   486  H HA   A LYS A 1 35  ? 29.88348 5.80028   9.45609  0.434 7.74896   ? 32  LYS A HA   1 
ATOM   487  H HA   B LYS A 1 35  ? 29.89608 5.79710   9.47057  0.566 7.64555   ? 32  LYS A HA   1 
ATOM   488  H HB2  A LYS A 1 35  ? 29.64496 4.97590   6.77874  0.434 17.24724  ? 32  LYS A HB2  1 
ATOM   489  H HB2  B LYS A 1 35  ? 29.44822 6.28098   7.17652  0.566 17.27908  ? 32  LYS A HB2  1 
ATOM   490  H HB3  A LYS A 1 35  ? 28.38385 5.02047   7.74468  0.434 17.24724  ? 32  LYS A HB3  1 
ATOM   491  H HB3  B LYS A 1 35  ? 29.40681 4.71432   6.91330  0.566 17.27908  ? 32  LYS A HB3  1 
ATOM   492  H HG2  A LYS A 1 35  ? 29.22038 7.42469   7.95246  0.434 20.44709  ? 32  LYS A HG2  1 
ATOM   493  H HG2  B LYS A 1 35  ? 27.52731 4.51953   8.24658  0.566 20.99980  ? 32  LYS A HG2  1 
ATOM   494  H HG3  A LYS A 1 35  ? 29.59553 7.10495   6.44169  0.434 20.44709  ? 32  LYS A HG3  1 
ATOM   495  H HG3  B LYS A 1 35  ? 27.58555 6.07207   8.58072  0.566 20.99980  ? 32  LYS A HG3  1 
ATOM   496  H HD2  A LYS A 1 35  ? 27.08240 6.26344   6.85120  0.434 33.43237  ? 32  LYS A HD2  1 
ATOM   497  H HD2  B LYS A 1 35  ? 26.91955 4.91157   6.08484  0.566 27.20724  ? 32  LYS A HD2  1 
ATOM   498  H HD3  A LYS A 1 35  ? 27.18056 7.76576   7.35995  0.434 33.43237  ? 32  LYS A HD3  1 
ATOM   499  H HD3  B LYS A 1 35  ? 26.01884 5.90956   6.93228  0.566 27.20724  ? 32  LYS A HD3  1 
ATOM   500  H HE2  A LYS A 1 35  ? 27.83648 8.48464   5.25778  0.434 48.68306  ? 32  LYS A HE2  1 
ATOM   501  H HE2  B LYS A 1 35  ? 27.47238 7.70116   6.33535  0.566 52.90659  ? 32  LYS A HE2  1 
ATOM   502  H HE3  A LYS A 1 35  ? 27.92135 6.98629   4.73513  0.434 48.68306  ? 32  LYS A HE3  1 
ATOM   503  H HE3  B LYS A 1 35  ? 28.32937 6.69595   5.45188  0.566 52.90659  ? 32  LYS A HE3  1 
ATOM   504  H HZ1  A LYS A 1 35  ? 25.95071 7.98065   4.04412  0.434 51.59143  ? 32  LYS A HZ1  1 
ATOM   505  H HZ1  B LYS A 1 35  ? 26.89248 7.89694   4.10348  0.566 58.90675  ? 32  LYS A HZ1  1 
ATOM   506  H HZ2  A LYS A 1 35  ? 25.62891 6.86092   4.90492  0.434 51.59143  ? 32  LYS A HZ2  1 
ATOM   507  H HZ2  B LYS A 1 35  ? 26.50225 6.50369   4.03349  0.566 58.90675  ? 32  LYS A HZ2  1 
ATOM   508  H HZ3  A LYS A 1 35  ? 25.54095 8.21433   5.41373  0.434 51.59143  ? 32  LYS A HZ3  1 
ATOM   509  H HZ3  B LYS A 1 35  ? 25.73136 7.43240   4.83445  0.566 58.90675  ? 32  LYS A HZ3  1 
ATOM   510  N N    . VAL A 1 36  ? 29.86614 3.60408   10.56431 1.000 12.88979  ? 33  VAL A N    1 
ATOM   511  C CA   . VAL A 1 36  ? 29.77706 2.31265   11.24386 1.000 4.51677   ? 33  VAL A CA   1 
ATOM   512  C C    . VAL A 1 36  ? 28.34254 1.99779   11.58036 1.000 9.76283   ? 33  VAL A C    1 
ATOM   513  O O    . VAL A 1 36  ? 27.65096 2.82726   12.18468 1.000 9.42260   ? 33  VAL A O    1 
ATOM   514  C CB   . VAL A 1 36  ? 30.61024 2.31991   12.54286 1.000 9.58188   ? 33  VAL A CB   1 
ATOM   515  C CG1  . VAL A 1 36  ? 30.48822 0.99879   13.22394 1.000 6.26471   ? 33  VAL A CG1  1 
ATOM   516  C CG2  . VAL A 1 36  ? 32.02938 2.71410   12.15271 1.000 6.42381   ? 33  VAL A CG2  1 
ATOM   517  H H    . VAL A 1 36  ? 29.76678 4.26642   11.10378 1.000 15.46777  ? 33  VAL A H    1 
ATOM   518  H HA   . VAL A 1 36  ? 30.09998 1.63224   10.63259 1.000 5.42014   ? 33  VAL A HA   1 
ATOM   519  H HB   . VAL A 1 36  ? 30.29931 2.96197   13.20012 1.000 11.49827  ? 33  VAL A HB   1 
ATOM   520  H HG11 . VAL A 1 36  ? 31.18918 0.92086   13.88988 1.000 7.51767   ? 33  VAL A HG11 1 
ATOM   521  H HG12 . VAL A 1 36  ? 29.61890 0.94254   13.65059 1.000 7.51767   ? 33  VAL A HG12 1 
ATOM   522  H HG13 . VAL A 1 36  ? 30.57905 0.29370   12.56402 1.000 7.51767   ? 33  VAL A HG13 1 
ATOM   523  H HG21 . VAL A 1 36  ? 32.59791 2.66428   12.93705 1.000 7.70859   ? 33  VAL A HG21 1 
ATOM   524  H HG22 . VAL A 1 36  ? 32.35100 2.10283   11.47168 1.000 7.70859   ? 33  VAL A HG22 1 
ATOM   525  H HG23 . VAL A 1 36  ? 32.02164 3.62030   11.80681 1.000 7.70859   ? 33  VAL A HG23 1 
ATOM   526  N N    . THR A 1 37  ? 27.95042 0.76496   11.30142 1.000 4.87204   ? 34  THR A N    1 
ATOM   527  C CA   . THR A 1 37  ? 26.68028 0.20180   11.69740 1.000 9.71697   ? 34  THR A CA   1 
ATOM   528  C C    . THR A 1 37  ? 26.95047 -0.94901  12.64237 1.000 7.96534   ? 34  THR A C    1 
ATOM   529  O O    . THR A 1 37  ? 27.57310 -1.94656  12.26315 1.000 9.89419   ? 34  THR A O    1 
ATOM   530  C CB   . THR A 1 37  ? 25.89618 -0.32547  10.49222 1.000 10.21158  ? 34  THR A CB   1 
ATOM   531  O OG1  . THR A 1 37  ? 25.75910 0.73614   9.55191  1.000 6.81234   ? 34  THR A OG1  1 
ATOM   532  C CG2  . THR A 1 37  ? 24.51462 -0.93606  10.90454 1.000 11.31228  ? 34  THR A CG2  1 
ATOM   533  H H    . THR A 1 37  ? 28.43325 0.20775   10.85870 1.000 5.84646   ? 34  THR A H    1 
ATOM   534  H HA   . THR A 1 37  ? 26.15597 0.88817   12.13887 1.000 11.66037  ? 34  THR A HA   1 
ATOM   535  H HB   . THR A 1 37  ? 26.37289 -1.05953  10.07412 1.000 12.25391  ? 34  THR A HB   1 
ATOM   536  H HG1  . THR A 1 37  ? 25.38192 0.45620   8.85551  1.000 8.17482   ? 34  THR A HG1  1 
ATOM   537  H HG21 . THR A 1 37  ? 23.97961 -1.10989  10.11431 1.000 13.57475  ? 34  THR A HG21 1 
ATOM   538  H HG22 . THR A 1 37  ? 24.64953 -1.76908  11.38284 1.000 13.57475  ? 34  THR A HG22 1 
ATOM   539  H HG23 . THR A 1 37  ? 24.03650 -0.31735  11.47855 1.000 13.57475  ? 34  THR A HG23 1 
ATOM   540  N N    . VAL A 1 38  ? 26.43711 -0.80551  13.83420 1.000 4.39812   ? 35  VAL A N    1 
ATOM   541  C CA   . VAL A 1 38  ? 26.50552 -1.84153  14.83068 1.000 3.83776   ? 35  VAL A CA   1 
ATOM   542  C C    . VAL A 1 38  ? 25.21694 -2.64666  14.69825 1.000 7.83213   ? 35  VAL A C    1 
ATOM   543  O O    . VAL A 1 38  ? 24.12079 -2.14221  14.95357 1.000 10.62029  ? 35  VAL A O    1 
ATOM   544  C CB   . VAL A 1 38  ? 26.68569 -1.23427  16.21609 1.000 8.73778   ? 35  VAL A CB   1 
ATOM   545  C CG1  . VAL A 1 38  ? 26.67703 -2.33861  17.12819 1.000 13.40681  ? 35  VAL A CG1  1 
ATOM   546  C CG2  . VAL A 1 38  ? 28.04232 -0.49085  16.32964 1.000 7.57923   ? 35  VAL A CG2  1 
ATOM   547  H H    . VAL A 1 38  ? 26.03076 -0.09584  14.10038 1.000 5.27776   ? 35  VAL A H    1 
ATOM   548  H HA   . VAL A 1 38  ? 27.25223 -2.44060  14.67440 1.000 4.60532   ? 35  VAL A HA   1 
ATOM   549  H HB   . VAL A 1 38  ? 25.98756 -0.58867  16.40768 1.000 10.48535  ? 35  VAL A HB   1 
ATOM   550  H HG11 . VAL A 1 38  ? 26.96228 -2.02876  18.00199 1.000 16.08819  ? 35  VAL A HG11 1 
ATOM   551  H HG12 . VAL A 1 38  ? 25.77721 -2.69688  17.18179 1.000 16.08819  ? 35  VAL A HG12 1 
ATOM   552  H HG13 . VAL A 1 38  ? 27.28587 -3.02066  16.80410 1.000 16.08819  ? 35  VAL A HG13 1 
ATOM   553  H HG21 . VAL A 1 38  ? 28.11548 -0.10061  17.21465 1.000 9.09510   ? 35  VAL A HG21 1 
ATOM   554  H HG22 . VAL A 1 38  ? 28.76265 -1.12464  16.18702 1.000 9.09510   ? 35  VAL A HG22 1 
ATOM   555  H HG23 . VAL A 1 38  ? 28.07744 0.20677   15.65658 1.000 9.09510   ? 35  VAL A HG23 1 
ATOM   556  N N    . ALA A 1 39  ? 25.32964 -3.87065  14.18531 1.000 10.29388  ? 36  ALA A N    1 
ATOM   557  C CA   . ALA A 1 39  ? 24.18637 -4.65295  13.79142 1.000 7.82244   ? 36  ALA A CA   1 
ATOM   558  C C    . ALA A 1 39  ? 24.00918 -5.79850  14.75935 1.000 10.49462  ? 36  ALA A C    1 
ATOM   559  O O    . ALA A 1 39  ? 24.96904 -6.51446  15.06576 1.000 11.24114  ? 36  ALA A O    1 
ATOM   560  C CB   . ALA A 1 39  ? 24.34449 -5.15681  12.34401 1.000 11.90183  ? 36  ALA A CB   1 
ATOM   561  H H    . ALA A 1 39  ? 26.08097 -4.26900  14.05722 1.000 12.35267  ? 36  ALA A H    1 
ATOM   562  H HA   . ALA A 1 39  ? 23.38138 -4.11301  13.82809 1.000 9.38694   ? 36  ALA A HA   1 
ATOM   563  H HB1  . ALA A 1 39  ? 23.55989 -5.67321  12.10190 1.000 14.28221  ? 36  ALA A HB1  1 
ATOM   564  H HB2  . ALA A 1 39  ? 24.43384 -4.39367  11.75195 1.000 14.28221  ? 36  ALA A HB2  1 
ATOM   565  H HB3  . ALA A 1 39  ? 25.13697 -5.71336  12.28816 1.000 14.28221  ? 36  ALA A HB3  1 
ATOM   566  N N    . GLY A 1 40  ? 22.80787 -5.92445  15.31674 1.000 8.98327   ? 37  GLY A N    1 
ATOM   567  C CA   . GLY A 1 40  ? 22.55921 -6.96062  16.31127 1.000 9.03914   ? 37  GLY A CA   1 
ATOM   568  C C    . GLY A 1 40  ? 22.19621 -8.25555  15.60796 1.000 13.91129  ? 37  GLY A C    1 
ATOM   569  O O    . GLY A 1 40  ? 21.33328 -8.26105  14.71810 1.000 10.68411  ? 37  GLY A O    1 
ATOM   570  H H    . GLY A 1 40  ? 22.12856 -5.42825  15.13807 1.000 10.77994  ? 37  GLY A H    1 
ATOM   571  H HA2  . GLY A 1 40  ? 23.35324 -7.10286  16.84995 1.000 10.84698  ? 37  GLY A HA2  1 
ATOM   572  H HA3  . GLY A 1 40  ? 21.82735 -6.69736  16.89090 1.000 10.84698  ? 37  GLY A HA3  1 
ATOM   573  N N    . LEU A 1 41  ? 22.89029 -9.34905  15.97891 1.000 14.29981  ? 38  LEU A N    1 
ATOM   574  C CA   . LEU A 1 41  ? 22.67886 -10.64922 15.33340 1.000 26.59599  ? 38  LEU A CA   1 
ATOM   575  C C    . LEU A 1 41  ? 21.22286 -11.08938 15.44674 1.000 23.66278  ? 38  LEU A C    1 
ATOM   576  O O    . LEU A 1 41  ? 20.64349 -11.56191 14.47616 1.000 24.36458  ? 38  LEU A O    1 
ATOM   577  C CB   . LEU A 1 41  ? 23.58002 -11.75186 15.93623 1.000 12.18313  ? 38  LEU A CB   1 
ATOM   578  C CG   . LEU A 1 41  ? 23.58387 -13.20176 15.38428 1.000 22.01410  ? 38  LEU A CG   1 
ATOM   579  C CD1  . LEU A 1 41  ? 24.09450 -13.11115 13.95208 1.000 27.08416  ? 38  LEU A CD1  1 
ATOM   580  C CD2  . LEU A 1 41  ? 24.46079 -14.07781 16.21108 1.000 29.69909  ? 38  LEU A CD2  1 
ATOM   581  H H    . LEU A 1 41  ? 23.48578 -9.36061  16.59929 1.000 17.15979  ? 38  LEU A H    1 
ATOM   582  H HA   . LEU A 1 41  ? 22.92291 -10.54256 14.40068 1.000 31.91520  ? 38  LEU A HA   1 
ATOM   583  H HB2  . LEU A 1 41  ? 24.49474 -11.43933 15.85549 1.000 14.61977  ? 38  LEU A HB2  1 
ATOM   584  H HB3  . LEU A 1 41  ? 23.33733 -11.82943 16.87217 1.000 14.61977  ? 38  LEU A HB3  1 
ATOM   585  H HG   . LEU A 1 41  ? 22.69997 -13.60051 15.40917 1.000 26.41693  ? 38  LEU A HG   1 
ATOM   586  H HD11 . LEU A 1 41  ? 23.33696 -13.10926 13.34624 1.000 32.50101  ? 38  LEU A HD11 1 
ATOM   587  H HD12 . LEU A 1 41  ? 24.60239 -12.29118 13.84916 1.000 32.50101  ? 38  LEU A HD12 1 
ATOM   588  H HD13 . LEU A 1 41  ? 24.66173 -13.87666 13.77002 1.000 32.50101  ? 38  LEU A HD13 1 
ATOM   589  H HD21 . LEU A 1 41  ? 24.39758 -14.98828 15.88252 1.000 35.63893  ? 38  LEU A HD21 1 
ATOM   590  H HD22 . LEU A 1 41  ? 25.37602 -13.76401 16.14197 1.000 35.63893  ? 38  LEU A HD22 1 
ATOM   591  H HD23 . LEU A 1 41  ? 24.16635 -14.03818 17.13446 1.000 35.63893  ? 38  LEU A HD23 1 
ATOM   592  N N    . ALA A 1 42  ? 20.61930 -10.91971 16.61727 1.000 21.80310  ? 39  ALA A N    1 
ATOM   593  C CA   . ALA A 1 42  ? 19.27393 -11.40214 16.90715 1.000 28.49434  ? 39  ALA A CA   1 
ATOM   594  C C    . ALA A 1 42  ? 18.13169 -10.39403 16.61801 1.000 26.69992  ? 39  ALA A C    1 
ATOM   595  O O    . ALA A 1 42  ? 16.95357 -10.76874 16.71249 1.000 33.97782  ? 39  ALA A O    1 
ATOM   596  C CB   . ALA A 1 42  ? 19.27408 -11.84886 18.37040 1.000 27.45798  ? 39  ALA A CB   1 
ATOM   597  H H    . ALA A 1 42  ? 20.98105 -10.51381 17.28360 1.000 26.16373  ? 39  ALA A H    1 
ATOM   598  H HA   . ALA A 1 42  ? 19.06048 -12.15459 16.33343 1.000 34.19322  ? 39  ALA A HA   1 
ATOM   599  H HB1  . ALA A 1 42  ? 18.39155 -12.17973 18.59968 1.000 32.94959  ? 39  ALA A HB1  1 
ATOM   600  H HB2  . ALA A 1 42  ? 19.93147 -12.55276 18.48563 1.000 32.94959  ? 39  ALA A HB2  1 
ATOM   601  H HB3  . ALA A 1 42  ? 19.49933 -11.09074 18.93202 1.000 32.94959  ? 39  ALA A HB3  1 
ATOM   602  N N    . GLY A 1 43  ? 18.43457 -9.15776  16.21722 1.000 22.27054  ? 40  GLY A N    1 
ATOM   603  C CA   . GLY A 1 43  ? 17.43597 -8.13741  16.02290 1.000 19.43668  ? 40  GLY A CA   1 
ATOM   604  C C    . GLY A 1 43  ? 17.91268 -6.80513  16.56964 1.000 28.38414  ? 40  GLY A C    1 
ATOM   605  O O    . GLY A 1 43  ? 19.07448 -6.64970  16.94648 1.000 18.22605  ? 40  GLY A O    1 
ATOM   606  H H    . GLY A 1 43  ? 19.23508 -8.89134  16.05048 1.000 26.72467  ? 40  GLY A H    1 
ATOM   607  H HA2  . GLY A 1 43  ? 17.24976 -8.03720  15.07623 1.000 23.32403  ? 40  GLY A HA2  1 
ATOM   608  H HA3  . GLY A 1 43  ? 16.61832 -8.38769  16.48082 1.000 23.32403  ? 40  GLY A HA3  1 
ATOM   609  N N    . LYS A 1 44  ? 17.02256 -5.82167  16.56649 1.000 16.55724  ? 41  LYS A N    1 
ATOM   610  C CA   . LYS A 1 44  ? 17.27841 -4.47184  17.07437 1.000 25.09711  ? 41  LYS A CA   1 
ATOM   611  C C    . LYS A 1 44  ? 17.31003 -4.41589  18.59890 1.000 18.91857  ? 41  LYS A C    1 
ATOM   612  O O    . LYS A 1 44  ? 17.52426 -3.34622  19.18425 1.000 22.77888  ? 41  LYS A O    1 
ATOM   613  C CB   . LYS A 1 44  ? 16.18475 -3.57178  16.47194 1.000 25.05929  ? 41  LYS A CB   1 
ATOM   614  C CG   . LYS A 1 44  ? 16.19827 -2.13866  16.88889 1.000 58.25698  ? 41  LYS A CG   1 
ATOM   615  C CD   . LYS A 1 44  ? 16.95995 -1.27698  15.86450 1.000 50.97210  ? 41  LYS A CD   1 
ATOM   616  C CE   . LYS A 1 44  ? 16.63022 0.23753   16.04045 1.000 52.45122  ? 41  LYS A CE   1 
ATOM   617  N NZ   . LYS A 1 44  ? 15.13483 0.47657   15.82780 1.000 63.76799  ? 41  LYS A NZ   1 
ATOM   618  H H    . LYS A 1 44  ? 16.22329 -5.91068  16.26177 1.000 19.86871  ? 41  LYS A H    1 
ATOM   619  H HA   . LYS A 1 44  ? 18.14330 -4.13088  16.79758 1.000 30.11655  ? 41  LYS A HA   1 
ATOM   620  H HB2  . LYS A 1 44  ? 16.27905 -3.58814  15.50668 1.000 30.07116  ? 41  LYS A HB2  1 
ATOM   621  H HB3  . LYS A 1 44  ? 15.32196 -3.93420  16.72718 1.000 30.07116  ? 41  LYS A HB3  1 
ATOM   622  H HG2  . LYS A 1 44  ? 15.28747 -1.81064  16.95006 1.000 69.90839  ? 41  LYS A HG2  1 
ATOM   623  H HG3  . LYS A 1 44  ? 16.63919 -2.05580  17.74890 1.000 69.90839  ? 41  LYS A HG3  1 
ATOM   624  H HD2  . LYS A 1 44  ? 17.91437 -1.39830  15.98802 1.000 61.16654  ? 41  LYS A HD2  1 
ATOM   625  H HD3  . LYS A 1 44  ? 16.70509 -1.54298  14.96717 1.000 61.16654  ? 41  LYS A HD3  1 
ATOM   626  H HE2  . LYS A 1 44  ? 16.86615 0.52112   16.93756 1.000 62.94147  ? 41  LYS A HE2  1 
ATOM   627  H HE3  . LYS A 1 44  ? 17.12436 0.75743   15.38743 1.000 62.94147  ? 41  LYS A HE3  1 
ATOM   628  H HZ1  . LYS A 1 44  ? 14.96931 1.34997   15.78454 1.000 76.52161  ? 41  LYS A HZ1  1 
ATOM   629  H HZ2  . LYS A 1 44  ? 14.87042 0.09453   15.06870 1.000 76.52161  ? 41  LYS A HZ2  1 
ATOM   630  H HZ3  . LYS A 1 44  ? 14.67177 0.12794   16.50318 1.000 76.52161  ? 41  LYS A HZ3  1 
ATOM   631  N N    . ASP A 1 45  ? 17.10268 -5.52959  19.26965 1.000 15.68699  ? 42  ASP A N    1 
ATOM   632  C CA   . ASP A 1 45  ? 16.95429 -5.38960  20.71807 1.000 11.11493  ? 42  ASP A CA   1 
ATOM   633  C C    . ASP A 1 45  ? 18.31196 -5.22030  21.39879 1.000 13.98681  ? 42  ASP A C    1 
ATOM   634  O O    . ASP A 1 45  ? 19.36871 -5.54599  20.85239 1.000 11.65781  ? 42  ASP A O    1 
ATOM   635  C CB   . ASP A 1 45  ? 16.21356 -6.58739  21.28955 1.000 22.53761  ? 42  ASP A CB   1 
ATOM   636  C CG   . ASP A 1 45  ? 14.78320 -6.69056  20.75663 1.000 45.98004  ? 42  ASP A CG   1 
ATOM   637  O OD1  . ASP A 1 45  ? 14.07027 -5.63668  20.71536 1.000 40.31022  ? 42  ASP A OD1  1 
ATOM   638  O OD2  . ASP A 1 45  ? 14.42416 -7.82700  20.34599 1.000 48.66654  ? 42  ASP A OD2  1 
ATOM   639  H H    . ASP A 1 45  ? 17.04671 -6.32265  18.94174 1.000 18.82440  ? 42  ASP A H    1 
ATOM   640  H HA   . ASP A 1 45  ? 16.43025 -4.59655  20.91135 1.000 13.33793  ? 42  ASP A HA   1 
ATOM   641  H HB2  . ASP A 1 45  ? 16.68589 -7.39911  21.04681 1.000 27.04515  ? 42  ASP A HB2  1 
ATOM   642  H HB3  . ASP A 1 45  ? 16.17118 -6.50434  22.25506 1.000 27.04515  ? 42  ASP A HB3  1 
ATOM   643  N N    . PRO A 1 46  ? 18.31025 -4.69224  22.59204 1.000 18.76851  ? 43  PRO A N    1 
ATOM   644  C CA   . PRO A 1 46  ? 19.58484 -4.49460  23.31300 1.000 10.94046  ? 43  PRO A CA   1 
ATOM   645  C C    . PRO A 1 46  ? 20.31077 -5.81818  23.58677 1.000 19.42267  ? 43  PRO A C    1 
ATOM   646  O O    . PRO A 1 46  ? 19.68352 -6.79525  23.97938 1.000 8.74627   ? 43  PRO A O    1 
ATOM   647  C CB   . PRO A 1 46  ? 19.14533 -3.82627  24.60965 1.000 16.98837  ? 43  PRO A CB   1 
ATOM   648  C CG   . PRO A 1 46  ? 17.77500 -3.22038  24.29666 1.000 26.93546  ? 43  PRO A CG   1 
ATOM   649  C CD   . PRO A 1 46  ? 17.14288 -4.17788  23.32933 1.000 24.22367  ? 43  PRO A CD   1 
ATOM   650  H HA   . PRO A 1 46  ? 20.16981 -3.90852  22.80781 1.000 13.12856  ? 43  PRO A HA   1 
ATOM   651  H HB2  . PRO A 1 46  ? 19.07954 -4.48747  25.31632 1.000 20.38606  ? 43  PRO A HB2  1 
ATOM   652  H HB3  . PRO A 1 46  ? 19.78119 -3.13721  24.85818 1.000 20.38606  ? 43  PRO A HB3  1 
ATOM   653  H HG2  . PRO A 1 46  ? 17.25015 -3.15084  25.10943 1.000 32.32257  ? 43  PRO A HG2  1 
ATOM   654  H HG3  . PRO A 1 46  ? 17.88414 -2.34368  23.89619 1.000 32.32257  ? 43  PRO A HG3  1 
ATOM   655  H HD2  . PRO A 1 46  ? 16.68184 -4.89244  23.79596 1.000 29.06842  ? 43  PRO A HD2  1 
ATOM   656  H HD3  . PRO A 1 46  ? 16.52860 -3.71935  22.73493 1.000 29.06842  ? 43  PRO A HD3  1 
ATOM   657  N N    . VAL A 1 47  ? 21.65637 -5.78564  23.53541 1.000 7.85811   ? 44  VAL A N    1 
ATOM   658  C CA   . VAL A 1 47  ? 22.52230 -6.97061  23.63195 1.000 3.01718   ? 44  VAL A CA   1 
ATOM   659  C C    . VAL A 1 47  ? 23.34808 -6.93546  24.91852 1.000 9.82655   ? 44  VAL A C    1 
ATOM   660  O O    . VAL A 1 47  ? 24.01979 -5.95160  25.18953 1.000 8.71002   ? 44  VAL A O    1 
ATOM   661  C CB   . VAL A 1 47  ? 23.44402 -7.03172  22.38671 1.000 6.66818   ? 44  VAL A CB   1 
ATOM   662  C CG1  . VAL A 1 47  ? 24.44001 -8.18348  22.44085 1.000 13.94580  ? 44  VAL A CG1  1 
ATOM   663  C CG2  . VAL A 1 47  ? 22.60685 -7.03459  21.10456 1.000 16.74243  ? 44  VAL A CG2  1 
ATOM   664  H H    . VAL A 1 47  ? 22.10466 -5.05778  23.44124 1.000 9.42975   ? 44  VAL A H    1 
ATOM   665  H HA   . VAL A 1 47  ? 21.96921 -7.76532  23.69052 1.000 3.62063   ? 44  VAL A HA   1 
ATOM   666  H HB   . VAL A 1 47  ? 23.99193 -6.23132  22.37908 1.000 8.00184   ? 44  VAL A HB   1 
ATOM   667  H HG11 . VAL A 1 47  ? 24.80879 -8.32400  21.55476 1.000 16.73498  ? 44  VAL A HG11 1 
ATOM   668  H HG12 . VAL A 1 47  ? 25.14969 -7.95832  23.06260 1.000 16.73498  ? 44  VAL A HG12 1 
ATOM   669  H HG13 . VAL A 1 47  ? 23.98088 -8.98428  22.73887 1.000 16.73498  ? 44  VAL A HG13 1 
ATOM   670  H HG21 . VAL A 1 47  ? 23.19413 -7.16840  20.34423 1.000 20.09093  ? 44  VAL A HG21 1 
ATOM   671  H HG22 . VAL A 1 47  ? 21.95843 -7.75443  21.15239 1.000 20.09093  ? 44  VAL A HG22 1 
ATOM   672  H HG23 . VAL A 1 47  ? 22.15002 -6.18272  21.02378 1.000 20.09093  ? 44  VAL A HG23 1 
ATOM   673  N N    . GLN A 1 48  ? 23.29514 -8.03407  25.68825 1.000 6.41543   ? 45  GLN A N    1 
ATOM   674  C CA   . GLN A 1 48  ? 24.00167 -8.20608  26.93263 1.000 6.77011   ? 45  GLN A CA   1 
ATOM   675  C C    . GLN A 1 48  ? 25.34142 -8.78380  26.59673 1.000 8.88923   ? 45  GLN A C    1 
ATOM   676  O O    . GLN A 1 48  ? 25.43515 -9.92975  26.15831 1.000 5.72200   ? 45  GLN A O    1 
ATOM   677  C CB   . GLN A 1 48  ? 23.24368 -9.15262  27.87581 1.000 12.82886  ? 45  GLN A CB   1 
ATOM   678  C CG   . GLN A 1 48  ? 23.86268 -9.31516  29.22979 1.000 29.08030  ? 45  GLN A CG   1 
ATOM   679  C CD   . GLN A 1 48  ? 23.12196 -10.32841 30.08608 1.000 32.61331  ? 45  GLN A CD   1 
ATOM   680  O OE1  . GLN A 1 48  ? 22.42412 -11.23591 29.58697 1.000 29.41106  ? 45  GLN A OE1  1 
ATOM   681  N NE2  . GLN A 1 48  ? 23.24791 -10.15277 31.38176 1.000 37.99296  ? 45  GLN A NE2  1 
ATOM   682  H H    . GLN A 1 48  ? 22.82494 -8.72498  25.48539 1.000 7.69853   ? 45  GLN A H    1 
ATOM   683  H HA   . GLN A 1 48  ? 24.09913 -7.34928  27.37681 1.000 8.12415   ? 45  GLN A HA   1 
ATOM   684  H HB2  . GLN A 1 48  ? 22.34677 -8.80632  28.00437 1.000 15.39465  ? 45  GLN A HB2  1 
ATOM   685  H HB3  . GLN A 1 48  ? 23.20464 -10.03056 27.46520 1.000 15.39465  ? 45  GLN A HB3  1 
ATOM   686  H HG2  . GLN A 1 48  ? 24.77787 -9.61945  29.12619 1.000 34.89638  ? 45  GLN A HG2  1 
ATOM   687  H HG3  . GLN A 1 48  ? 23.84697 -8.46183  29.69074 1.000 34.89638  ? 45  GLN A HG3  1 
ATOM   688  H HE21 . GLN A 1 48  ? 23.72227 -9.50191  31.68336 1.000 45.59157  ? 45  GLN A HE21 1 
ATOM   689  H HE22 . GLN A 1 48  ? 22.85601 -10.68865 31.92844 1.000 45.59157  ? 45  GLN A HE22 1 
ATOM   690  N N    . CYS A 1 49  ? 26.37712 -7.97567  26.75337 1.000 12.13687  ? 46  CYS A N    1 
ATOM   691  C CA   . CYS A 1 49  ? 27.70291 -8.43854  26.51240 1.000 7.51560   ? 46  CYS A CA   1 
ATOM   692  C C    . CYS A 1 49  ? 28.25811 -9.24727  27.66516 1.000 5.26623   ? 46  CYS A C    1 
ATOM   693  O O    . CYS A 1 49  ? 27.62226 -9.55298  28.67454 1.000 5.79439   ? 46  CYS A O    1 
ATOM   694  C CB   . CYS A 1 49  ? 28.60248 -7.23580  26.19689 1.000 7.66995   ? 46  CYS A CB   1 
ATOM   695  S SG   . CYS A 1 49  ? 28.05431 -6.36334  24.69912 1.000 9.85651   ? 46  CYS A SG   1 
ATOM   696  H H    . CYS A 1 49  ? 26.32394 -7.15350  26.99997 1.000 14.56426  ? 46  CYS A H    1 
ATOM   697  H HA   . CYS A 1 49  ? 27.67384 -9.04005  25.75197 1.000 9.01873   ? 46  CYS A HA   1 
ATOM   698  H HB2  . CYS A 1 49  ? 28.57591 -6.61285  26.93993 1.000 9.20396   ? 46  CYS A HB2  1 
ATOM   699  H HB3  . CYS A 1 49  ? 29.51107 -7.54442  26.05502 1.000 9.20396   ? 46  CYS A HB3  1 
ATOM   700  H HG   . CYS A 1 49  ? 28.80079 -5.44861  24.48455 1.000 11.82783  ? 46  CYS A HG   1 
ATOM   701  N N    . SER A 1 50  ? 29.49508 -9.67161  27.43510 1.000 3.78554   ? 47  SER A N    1 
ATOM   702  C CA   . SER A 1 50  ? 30.06831 -10.71720 28.26247 1.000 4.06657   ? 47  SER A CA   1 
ATOM   703  C C    . SER A 1 50  ? 30.21167 -10.25801 29.67691 1.000 5.29068   ? 47  SER A C    1 
ATOM   704  O O    . SER A 1 50  ? 30.10206 -11.06482 30.60158 1.000 3.44193   ? 47  SER A O    1 
ATOM   705  C CB   . SER A 1 50  ? 31.43302 -11.17342 27.76129 1.000 7.11961   ? 47  SER A CB   1 
ATOM   706  O OG   . SER A 1 50  ? 32.43027 -10.13798 27.82824 1.000 4.53381   ? 47  SER A OG   1 
ATOM   707  H H    . SER A 1 50  ? 30.01322 -9.37451  26.81634 1.000 4.54266   ? 47  SER A H    1 
ATOM   708  H HA   . SER A 1 50  ? 29.46614 -11.47584 28.20996 1.000 4.87990   ? 47  SER A HA   1 
ATOM   709  H HB2  . SER A 1 50  ? 31.72729 -11.91923 28.30725 1.000 8.54354   ? 47  SER A HB2  1 
ATOM   710  H HB3  . SER A 1 50  ? 31.34293 -11.45399 26.83713 1.000 8.54354   ? 47  SER A HB3  1 
ATOM   711  H HG   . SER A 1 50  ? 32.18118 -9.47004  27.38394 1.000 5.44059   ? 47  SER A HG   1 
ATOM   712  N N    . ARG A 1 51  ? 30.60136 -8.98763  29.87496 1.000 3.24687   ? 48  ARG A N    1 
ATOM   713  C CA   . ARG A 1 51  ? 30.71712 -8.46191  31.23610 1.000 4.76566   ? 48  ARG A CA   1 
ATOM   714  C C    . ARG A 1 51  ? 29.48122 -7.62235  31.61785 1.000 4.39471   ? 48  ARG A C    1 
ATOM   715  O O    . ARG A 1 51  ? 29.59088 -6.71162  32.44808 1.000 7.52327   ? 48  ARG A O    1 
ATOM   716  C CB   . ARG A 1 51  ? 32.03657 -7.66741  31.40733 1.000 4.78668   ? 48  ARG A CB   1 
ATOM   717  C CG   . ARG A 1 51  ? 33.21046 -8.55626  31.96103 1.000 6.50410   ? 48  ARG A CG   1 
ATOM   718  C CD   . ARG A 1 51  ? 33.61492 -9.54810  30.86978 1.000 6.14765   ? 48  ARG A CD   1 
ATOM   719  N NE   . ARG A 1 51  ? 34.58474 -10.57108 31.25030 1.000 3.04630   ? 48  ARG A NE   1 
ATOM   720  C CZ   . ARG A 1 51  ? 35.02856 -11.50283 30.41645 1.000 12.52650  ? 48  ARG A CZ   1 
ATOM   721  N NH1  . ARG A 1 51  ? 34.58032 -11.58371 29.16916 1.000 7.63481   ? 48  ARG A NH1  1 
ATOM   722  N NH2  . ARG A 1 51  ? 35.93534 -12.36040 30.84453 1.000 8.55191   ? 48  ARG A NH2  1 
ATOM   723  H H    . ARG A 1 51  ? 30.79762 -8.43042  29.24998 1.000 3.89625   ? 48  ARG A H    1 
ATOM   724  H HA   . ARG A 1 51  ? 30.76747 -9.20044  31.86294 1.000 5.71881   ? 48  ARG A HA   1 
ATOM   725  H HB2  . ARG A 1 51  ? 32.30718 -7.31431  30.54536 1.000 5.74403   ? 48  ARG A HB2  1 
ATOM   726  H HB3  . ARG A 1 51  ? 31.88903 -6.94032  32.03220 1.000 5.74403   ? 48  ARG A HB3  1 
ATOM   727  H HG2  . ARG A 1 51  ? 33.97317 -8.00023  32.18467 1.000 7.80494   ? 48  ARG A HG2  1 
ATOM   728  H HG3  . ARG A 1 51  ? 32.91657 -9.04697  32.74444 1.000 7.80494   ? 48  ARG A HG3  1 
ATOM   729  H HD2  . ARG A 1 51  ? 32.81649 -10.01064 30.57067 1.000 7.37720   ? 48  ARG A HD2  1 
ATOM   730  H HD3  . ARG A 1 51  ? 34.00321 -9.04759  30.13519 1.000 7.37720   ? 48  ARG A HD3  1 
ATOM   731  H HE   . ARG A 1 51  ? 34.88377 -10.56962 32.05663 1.000 3.65557   ? 48  ARG A HE   1 
ATOM   732  H HH11 . ARG A 1 51  ? 33.99033 -11.02513 28.88719 1.000 9.16179   ? 48  ARG A HH11 1 
ATOM   733  H HH12 . ARG A 1 51  ? 34.88000 -12.19466 28.64331 1.000 9.16179   ? 48  ARG A HH12 1 
ATOM   734  H HH21 . ARG A 1 51  ? 36.22833 -12.30937 31.65148 1.000 10.26231  ? 48  ARG A HH21 1 
ATOM   735  H HH22 . ARG A 1 51  ? 36.23338 -12.97038 30.31662 1.000 10.26231  ? 48  ARG A HH22 1 
ATOM   736  N N    . ASP A 1 52  ? 28.30352 -7.91299  31.02844 1.000 6.95970   ? 49  ASP A N    1 
ATOM   737  C CA   . ASP A 1 52  ? 26.97196 -7.40338  31.40084 1.000 15.83358  ? 49  ASP A CA   1 
ATOM   738  C C    . ASP A 1 52  ? 26.76287 -5.95321  31.02197 1.000 11.08420  ? 49  ASP A C    1 
ATOM   739  O O    . ASP A 1 52  ? 25.71525 -5.34956  31.32246 1.000 6.59507   ? 49  ASP A O    1 
ATOM   740  C CB   . ASP A 1 52  ? 26.69090 -7.64810  32.88274 1.000 10.23854  ? 49  ASP A CB   1 
ATOM   741  C CG   . ASP A 1 52  ? 26.12324 -9.06038  33.11802 1.000 16.73833  ? 49  ASP A CG   1 
ATOM   742  O OD1  . ASP A 1 52  ? 25.72680 -9.79658  32.17542 1.000 16.77108  ? 49  ASP A OD1  1 
ATOM   743  O OD2  . ASP A 1 52  ? 26.04466 -9.42512  34.28739 1.000 19.99904  ? 49  ASP A OD2  1 
ATOM   744  H H    . ASP A 1 52  ? 28.25135 -8.44706  30.35639 1.000 8.35165   ? 49  ASP A H    1 
ATOM   745  H HA   . ASP A 1 52  ? 26.29813 -7.89020  30.90098 1.000 19.00032  ? 49  ASP A HA   1 
ATOM   746  H HB2  . ASP A 1 52  ? 27.51613 -7.56214  33.38526 1.000 12.28626  ? 49  ASP A HB2  1 
ATOM   747  H HB3  . ASP A 1 52  ? 26.04133 -7.00050  33.19829 1.000 12.28626  ? 49  ASP A HB3  1 
ATOM   748  N N    . VAL A 1 53  ? 27.70700 -5.39970  30.27562 1.000 6.45587   ? 50  VAL A N    1 
ATOM   749  C CA   . VAL A 1 53  ? 27.43226 -4.13996  29.65008 1.000 3.63845   ? 50  VAL A CA   1 
ATOM   750  C C    . VAL A 1 53  ? 26.37136 -4.40480  28.59339 1.000 6.82984   ? 50  VAL A C    1 
ATOM   751  O O    . VAL A 1 53  ? 26.42815 -5.41823  27.87857 1.000 5.44162   ? 50  VAL A O    1 
ATOM   752  C CB   . VAL A 1 53  ? 28.70774 -3.54440  29.04045 1.000 8.43421   ? 50  VAL A CB   1 
ATOM   753  C CG1  . VAL A 1 53  ? 28.31228 -2.32278  28.26861 1.000 6.03342   ? 50  VAL A CG1  1 
ATOM   754  C CG2  . VAL A 1 53  ? 29.72282 -3.23099  30.10762 1.000 14.81396  ? 50  VAL A CG2  1 
ATOM   755  H H    . VAL A 1 53  ? 28.48673 -5.73046  30.12656 1.000 7.74706   ? 50  VAL A H    1 
ATOM   756  H HA   . VAL A 1 53  ? 27.10842 -3.49311  30.29631 1.000 4.36615   ? 50  VAL A HA   1 
ATOM   757  H HB   . VAL A 1 53  ? 29.13609 -4.17906  28.44494 1.000 10.12107  ? 50  VAL A HB   1 
ATOM   758  H HG11 . VAL A 1 53  ? 29.09811 -1.77309  28.12301 1.000 7.24012   ? 50  VAL A HG11 1 
ATOM   759  H HG12 . VAL A 1 53  ? 27.93675 -2.59526  27.41677 1.000 7.24012   ? 50  VAL A HG12 1 
ATOM   760  H HG13 . VAL A 1 53  ? 27.65188 -1.82746  28.77796 1.000 7.24012   ? 50  VAL A HG13 1 
ATOM   761  H HG21 . VAL A 1 53  ? 30.48632 -2.79422  29.69872 1.000 17.77677  ? 50  VAL A HG21 1 
ATOM   762  H HG22 . VAL A 1 53  ? 29.31862 -2.64347  30.76514 1.000 17.77677  ? 50  VAL A HG22 1 
ATOM   763  H HG23 . VAL A 1 53  ? 30.00217 -4.05810  30.53041 1.000 17.77677  ? 50  VAL A HG23 1 
ATOM   764  N N    . VAL A 1 54  ? 25.38949 -3.53403  28.51542 1.000 4.40788   ? 51  VAL A N    1 
ATOM   765  C CA   . VAL A 1 54  ? 24.28956 -3.70644  27.58088 1.000 9.76061   ? 51  VAL A CA   1 
ATOM   766  C C    . VAL A 1 54  ? 24.27301 -2.56201  26.55992 1.000 9.26763   ? 51  VAL A C    1 
ATOM   767  O O    . VAL A 1 54  ? 24.08632 -1.39323  26.90756 1.000 7.79185   ? 51  VAL A O    1 
ATOM   768  C CB   . VAL A 1 54  ? 22.93315 -3.80872  28.29003 1.000 15.89233  ? 51  VAL A CB   1 
ATOM   769  C CG1  . VAL A 1 54  ? 21.83670 -3.90113  27.21703 1.000 10.12105  ? 51  VAL A CG1  1 
ATOM   770  C CG2  . VAL A 1 54  ? 22.88681 -4.95966  29.35857 1.000 12.32917  ? 51  VAL A CG2  1 
ATOM   771  H H    . VAL A 1 54  ? 25.33363 -2.82446  28.99811 1.000 5.28947   ? 51  VAL A H    1 
ATOM   772  H HA   . VAL A 1 54  ? 24.45725 -4.52639  27.09052 1.000 11.71275  ? 51  VAL A HA   1 
ATOM   773  H HB   . VAL A 1 54  ? 22.77153 -3.01282  28.82043 1.000 19.07082  ? 51  VAL A HB   1 
ATOM   774  H HG11 . VAL A 1 54  ? 21.01276 -4.20028  27.63241 1.000 12.14527  ? 51  VAL A HG11 1 
ATOM   775  H HG12 . VAL A 1 54  ? 21.70822 -3.02524  26.82054 1.000 12.14527  ? 51  VAL A HG12 1 
ATOM   776  H HG13 . VAL A 1 54  ? 22.11322 -4.53485  26.53671 1.000 12.14527  ? 51  VAL A HG13 1 
ATOM   777  H HG21 . VAL A 1 54  ? 21.99434 -5.00449  29.73592 1.000 14.79502  ? 51  VAL A HG21 1 
ATOM   778  H HG22 . VAL A 1 54  ? 23.10608 -5.80024  28.92702 1.000 14.79502  ? 51  VAL A HG22 1 
ATOM   779  H HG23 . VAL A 1 54  ? 23.53205 -4.76825  30.05708 1.000 14.79502  ? 51  VAL A HG23 1 
ATOM   780  N N    . ILE A 1 55  ? 24.35082 -2.92840  25.29397 1.000 2.21686   ? 52  ILE A N    1 
ATOM   781  C CA   . ILE A 1 55  ? 24.53307 -2.00893  24.19343 1.000 4.96202   ? 52  ILE A CA   1 
ATOM   782  C C    . ILE A 1 55  ? 23.32240 -2.10607  23.26535 1.000 10.03957  ? 52  ILE A C    1 
ATOM   783  O O    . ILE A 1 55  ? 22.88422 -3.21280  22.95287 1.000 9.85818   ? 52  ILE A O    1 
ATOM   784  C CB   . ILE A 1 55  ? 25.81994 -2.35395  23.43350 1.000 10.95915  ? 52  ILE A CB   1 
ATOM   785  C CG1  . ILE A 1 55  ? 27.02952 -2.02258  24.32135 1.000 10.19279  ? 52  ILE A CG1  1 
ATOM   786  C CG2  . ILE A 1 55  ? 25.83055 -1.61941  22.11538 1.000 13.85268  ? 52  ILE A CG2  1 
ATOM   787  C CD1  . ILE A 1 55  ? 28.38042 -2.34294  23.68488 1.000 22.36636  ? 52  ILE A CD1  1 
ATOM   788  H H    . ILE A 1 55  ? 24.29773 -3.74725  25.03654 1.000 2.66024   ? 52  ILE A H    1 
ATOM   789  H HA   . ILE A 1 55  ? 24.58271 -1.09803  24.52312 1.000 5.95444   ? 52  ILE A HA   1 
ATOM   790  H HB   . ILE A 1 55  ? 25.86363 -3.30172  23.23167 1.000 13.15100  ? 52  ILE A HB   1 
ATOM   791  H HG12 . ILE A 1 55  ? 27.01645 -1.07357  24.52161 1.000 12.23136  ? 52  ILE A HG12 1 
ATOM   792  H HG13 . ILE A 1 55  ? 26.96186 -2.53573  25.14171 1.000 12.23136  ? 52  ILE A HG13 1 
ATOM   793  H HG21 . ILE A 1 55  ? 26.73411 -1.61682  21.76256 1.000 16.62323  ? 52  ILE A HG21 1 
ATOM   794  H HG22 . ILE A 1 55  ? 25.23533 -2.07147  21.49713 1.000 16.62323  ? 52  ILE A HG22 1 
ATOM   795  H HG23 . ILE A 1 55  ? 25.52889 -0.70875  22.25890 1.000 16.62323  ? 52  ILE A HG23 1 
ATOM   796  H HD11 . ILE A 1 55  ? 29.06941 -2.29647  24.36608 1.000 26.83965  ? 52  ILE A HD11 1 
ATOM   797  H HD12 . ILE A 1 55  ? 28.34794 -3.23599  23.30764 1.000 26.83965  ? 52  ILE A HD12 1 
ATOM   798  H HD13 . ILE A 1 55  ? 28.56188 -1.69509  22.98613 1.000 26.83965  ? 52  ILE A HD13 1 
ATOM   799  N N    . CYS A 1 56  ? 22.81160 -0.95416  22.80832 1.000 5.78662   ? 53  CYS A N    1 
ATOM   800  C CA   . CYS A 1 56  ? 21.71126 -0.92426  21.84069 1.000 5.26888   ? 53  CYS A CA   1 
ATOM   801  C C    . CYS A 1 56  ? 22.27686 -0.87768  20.42993 1.000 9.93084   ? 53  CYS A C    1 
ATOM   802  O O    . CYS A 1 56  ? 23.00952 0.07872   20.09808 1.000 14.70123  ? 53  CYS A O    1 
ATOM   803  C CB   . CYS A 1 56  ? 20.84500 0.31270   22.02055 1.000 10.60074  ? 53  CYS A CB   1 
ATOM   804  S SG   . CYS A 1 56  ? 19.99357 0.33775   23.59482 1.000 26.74846  ? 53  CYS A SG   1 
ATOM   805  H H    . CYS A 1 56  ? 23.08747 -0.17491  23.04550 1.000 6.94396   ? 53  CYS A H    1 
ATOM   806  H HA   . CYS A 1 56  ? 21.17266 -1.72098  21.96742 1.000 6.32267   ? 53  CYS A HA   1 
ATOM   807  H HB2  . CYS A 1 56  ? 21.40699 1.10171   21.97016 1.000 12.72090  ? 53  CYS A HB2  1 
ATOM   808  H HB3  . CYS A 1 56  ? 20.17732 0.33549   21.31729 1.000 12.72090  ? 53  CYS A HB3  1 
ATOM   809  H HG   . CYS A 1 56  ? 19.34608 1.34506   23.67280 1.000 32.09816  ? 53  CYS A HG   1 
ATOM   810  N N    . PRO A 1 57  ? 21.99510 -1.84598  19.57615 1.000 8.07096   ? 54  PRO A N    1 
ATOM   811  C CA   A PRO A 1 57  ? 22.53649 -1.78216  18.20815 0.609 8.82000   ? 54  PRO A CA   1 
ATOM   812  C CA   B PRO A 1 57  ? 22.53464 -1.78215  18.20929 0.391 8.81739   ? 54  PRO A CA   1 
ATOM   813  C C    . PRO A 1 57  ? 21.83317 -0.71199  17.38892 1.000 5.49169   ? 54  PRO A C    1 
ATOM   814  O O    . PRO A 1 57  ? 20.75202 -0.22126  17.72967 1.000 7.93821   ? 54  PRO A O    1 
ATOM   815  C CB   A PRO A 1 57  ? 22.27908 -3.18555  17.65271 0.609 7.72154   ? 54  PRO A CB   1 
ATOM   816  C CB   B PRO A 1 57  ? 22.27956 -3.18585  17.64299 0.391 7.74696   ? 54  PRO A CB   1 
ATOM   817  C CG   A PRO A 1 57  ? 21.02896 -3.67705  18.45732 0.609 11.38694  ? 54  PRO A CG   1 
ATOM   818  C CG   B PRO A 1 57  ? 21.96951 -4.04715  18.85076 0.391 5.73831   ? 54  PRO A CG   1 
ATOM   819  C CD   A PRO A 1 57  ? 21.17387 -3.04936  19.82253 0.609 8.89952   ? 54  PRO A CD   1 
ATOM   820  C CD   B PRO A 1 57  ? 21.34134 -3.13177  19.86220 0.391 8.89635   ? 54  PRO A CD   1 
ATOM   821  H HA   A PRO A 1 57  ? 23.49167 -1.61335  18.21414 0.609 10.58402  ? 54  PRO A HA   1 
ATOM   822  H HA   B PRO A 1 57  ? 23.48999 -1.61463  18.22144 0.391 10.58088  ? 54  PRO A HA   1 
ATOM   823  H HB2  A PRO A 1 57  ? 22.09086 -3.14107  16.70218 0.609 9.26587   ? 54  PRO A HB2  1 
ATOM   824  H HB2  B PRO A 1 57  ? 21.52743 -3.16300  17.03088 0.391 9.29637   ? 54  PRO A HB2  1 
ATOM   825  H HB3  A PRO A 1 57  ? 23.04722 -3.75593  17.81247 0.609 9.26587   ? 54  PRO A HB3  1 
ATOM   826  H HB3  B PRO A 1 57  ? 23.07181 -3.50516  17.18333 0.391 9.29637   ? 54  PRO A HB3  1 
ATOM   827  H HG2  A PRO A 1 57  ? 20.21600 -3.37651  18.02181 0.609 13.66434  ? 54  PRO A HG2  1 
ATOM   828  H HG2  B PRO A 1 57  ? 21.35434 -4.75353  18.59877 0.391 6.88598   ? 54  PRO A HG2  1 
ATOM   829  H HG3  A PRO A 1 57  ? 21.03428 -4.64512  18.51824 0.609 13.66434  ? 54  PRO A HG3  1 
ATOM   830  H HG3  B PRO A 1 57  ? 22.79026 -4.43021  19.19795 0.391 6.88598   ? 54  PRO A HG3  1 
ATOM   831  H HD2  A PRO A 1 57  ? 20.30639 -2.80475  20.18107 0.609 10.67944  ? 54  PRO A HD2  1 
ATOM   832  H HD2  B PRO A 1 57  ? 20.38229 -3.07201  19.72973 0.391 10.67563  ? 54  PRO A HD2  1 
ATOM   833  H HD3  A PRO A 1 57  ? 21.62602 -3.65404  20.43148 0.609 10.67944  ? 54  PRO A HD3  1 
ATOM   834  H HD3  B PRO A 1 57  ? 21.53366 -3.42688  20.76598 0.391 10.67563  ? 54  PRO A HD3  1 
ATOM   835  N N    . ASP A 1 58  ? 22.49488 -0.32514  16.31790 1.000 6.21372   ? 55  ASP A N    1 
ATOM   836  C CA   . ASP A 1 58  ? 21.93862 0.63699   15.37300 1.000 11.95558  ? 55  ASP A CA   1 
ATOM   837  C C    . ASP A 1 58  ? 20.82008 0.01288   14.53431 1.000 10.77572  ? 55  ASP A C    1 
ATOM   838  O O    . ASP A 1 58  ? 19.88526 0.70409   14.10521 1.000 17.56589  ? 55  ASP A O    1 
ATOM   839  C CB   . ASP A 1 58  ? 23.05695 1.12397   14.45825 1.000 12.39604  ? 55  ASP A CB   1 
ATOM   840  C CG   . ASP A 1 58  ? 24.20238 1.83690   15.21688 1.000 18.05920  ? 55  ASP A CG   1 
ATOM   841  O OD1  . ASP A 1 58  ? 23.92360 2.59002   16.15722 1.000 10.50650  ? 55  ASP A OD1  1 
ATOM   842  O OD2  . ASP A 1 58  ? 25.40474 1.66081   14.88093 1.000 12.88308  ? 55  ASP A OD2  1 
ATOM   843  H H    . ASP A 1 58  ? 23.28001 -0.60438  16.10530 1.000 7.45648   ? 55  ASP A H    1 
ATOM   844  H HA   . ASP A 1 58  ? 21.56730 1.39163   15.85626 1.000 14.34671  ? 55  ASP A HA   1 
ATOM   845  H HB2  . ASP A 1 58  ? 23.43687 0.36187   13.99375 1.000 14.87526  ? 55  ASP A HB2  1 
ATOM   846  H HB3  . ASP A 1 58  ? 22.68774 1.75233   13.81813 1.000 14.87526  ? 55  ASP A HB3  1 
ATOM   847  N N    . ALA A 1 59  ? 20.94793 -1.25098  14.22916 1.000 12.25333  ? 56  ALA A N    1 
ATOM   848  C CA   . ALA A 1 59  ? 20.00511 -1.90562  13.32823 1.000 19.73267  ? 56  ALA A CA   1 
ATOM   849  C C    . ALA A 1 59  ? 20.05822 -3.38651  13.63096 1.000 16.81379  ? 56  ALA A C    1 
ATOM   850  O O    . ALA A 1 59  ? 21.01319 -3.87088  14.26064 1.000 15.63168  ? 56  ALA A O    1 
ATOM   851  C CB   . ALA A 1 59  ? 20.34467 -1.61377  11.86250 1.000 15.77535  ? 56  ALA A CB   1 
ATOM   852  H H    A ALA A 1 59  ? 21.57114 -1.76397  14.52591 0.670 14.70401  ? 56  ALA A H    1 
ATOM   853  H H    B ALA A 1 59  ? 21.57114 -1.76397  14.52591 0.330 14.70401  ? 56  ALA A H    1 
ATOM   854  H HA   . ALA A 1 59  ? 19.10338 -1.58570  13.48772 1.000 23.67922  ? 56  ALA A HA   1 
ATOM   855  H HB1  . ALA A 1 59  ? 19.68784 -2.04558  11.29415 1.000 18.93043  ? 56  ALA A HB1  1 
ATOM   856  H HB2  . ALA A 1 59  ? 20.32666 -0.65460  11.71911 1.000 18.93043  ? 56  ALA A HB2  1 
ATOM   857  H HB3  . ALA A 1 59  ? 21.22940 -1.96072  11.66817 1.000 18.93043  ? 56  ALA A HB3  1 
ATOM   858  N N    . SER A 1 60  ? 19.01933 -4.10316  13.21294 1.000 13.77272  ? 57  SER A N    1 
ATOM   859  C CA   . SER A 1 60  ? 19.13121 -5.55981  13.12549 1.000 13.31949  ? 57  SER A CA   1 
ATOM   860  C C    . SER A 1 60  ? 20.12716 -5.91052  12.01634 1.000 10.28124  ? 57  SER A C    1 
ATOM   861  O O    . SER A 1 60  ? 20.34535 -5.13908  11.07525 1.000 12.69292  ? 57  SER A O    1 
ATOM   862  C CB   . SER A 1 60  ? 17.76681 -6.20394  12.81333 1.000 13.96301  ? 57  SER A CB   1 
ATOM   863  O OG   . SER A 1 60  ? 17.42265 -5.91377  11.47661 1.000 20.76986  ? 57  SER A OG   1 
ATOM   864  H H    . SER A 1 60  ? 18.25700 -3.78079  12.97944 1.000 16.52728  ? 57  SER A H    1 
ATOM   865  H HA   . SER A 1 60  ? 19.43587 -5.92072  13.97274 1.000 15.98341  ? 57  SER A HA   1 
ATOM   866  H HB2  . SER A 1 60  ? 17.82779 -7.16486  12.93083 1.000 16.75563  ? 57  SER A HB2  1 
ATOM   867  H HB3  . SER A 1 60  ? 17.09277 -5.83912  13.40786 1.000 16.75563  ? 57  SER A HB3  1 
ATOM   868  H HG   . SER A 1 60  ? 16.61238 -6.09089  11.34363 1.000 24.92385  ? 57  SER A HG   1 
ATOM   869  N N    . LEU A 1 61  ? 20.74420 -7.09229  12.12860 1.000 14.92043  ? 58  LEU A N    1 
ATOM   870  C CA   . LEU A 1 61  ? 21.55503 -7.62028  11.02030 1.000 13.69912  ? 58  LEU A CA   1 
ATOM   871  C C    . LEU A 1 61  ? 20.73457 -7.82708  9.72229  1.000 23.58407  ? 58  LEU A C    1 
ATOM   872  O O    . LEU A 1 61  ? 21.23857 -7.55628  8.62650  1.000 12.47340  ? 58  LEU A O    1 
ATOM   873  C CB   . LEU A 1 61  ? 22.24158 -8.92443  11.46630 1.000 12.46922  ? 58  LEU A CB   1 
ATOM   874  C CG   . LEU A 1 61  ? 23.27884 -9.52874  10.50679 1.000 18.09344  ? 58  LEU A CG   1 
ATOM   875  C CD1  . LEU A 1 61  ? 24.38106 -8.53903  10.21112 1.000 16.15211  ? 58  LEU A CD1  1 
ATOM   876  C CD2  . LEU A 1 61  ? 23.91863 -10.84569 11.02113 1.000 16.33358  ? 58  LEU A CD2  1 
ATOM   877  H H    . LEU A 1 61  ? 20.71178 -7.60060  12.82154 1.000 17.90453  ? 58  LEU A H    1 
ATOM   878  H HA   . LEU A 1 61  ? 22.24135 -6.97007  10.80327 1.000 16.43896  ? 58  LEU A HA   1 
ATOM   879  H HB2  . LEU A 1 61  ? 22.69858 -8.75004  12.30394 1.000 14.96308  ? 58  LEU A HB2  1 
ATOM   880  H HB3  . LEU A 1 61  ? 21.55287 -9.59479  11.59743 1.000 14.96308  ? 58  LEU A HB3  1 
ATOM   881  H HG   . LEU A 1 61  ? 22.79205 -9.74433  9.69595  1.000 21.71214  ? 58  LEU A HG   1 
ATOM   882  H HD11 . LEU A 1 61  ? 25.15187 -9.01786  9.86839  1.000 19.38255  ? 58  LEU A HD11 1 
ATOM   883  H HD12 . LEU A 1 61  ? 24.06566 -7.90334  9.54981  1.000 19.38255  ? 58  LEU A HD12 1 
ATOM   884  H HD13 . LEU A 1 61  ? 24.61693 -8.07516  11.02971 1.000 19.38255  ? 58  LEU A HD13 1 
ATOM   885  H HD21 . LEU A 1 61  ? 24.52657 -11.18605 10.34626 1.000 19.60031  ? 58  LEU A HD21 1 
ATOM   886  H HD22 . LEU A 1 61  ? 24.40364 -10.66205 11.84085 1.000 19.60031  ? 58  LEU A HD22 1 
ATOM   887  H HD23 . LEU A 1 61  ? 23.21626 -11.49297 11.19030 1.000 19.60031  ? 58  LEU A HD23 1 
ATOM   888  N N    A GLU A 1 62  ? 19.48030 -8.29214  9.82259  0.504 23.78144  ? 59  GLU A N    1 
ATOM   889  N N    B GLU A 1 62  ? 19.48037 -8.29605  9.82700  0.496 23.77485  ? 59  GLU A N    1 
ATOM   890  C CA   A GLU A 1 62  ? 18.66198 -8.43619  8.61293  0.504 26.49524  ? 59  GLU A CA   1 
ATOM   891  C CA   B GLU A 1 62  ? 18.63998 -8.43638  8.63070  0.496 26.48430  ? 59  GLU A CA   1 
ATOM   892  C C    A GLU A 1 62  ? 18.54303 -7.10696  7.85851  0.504 16.62157  ? 59  GLU A C    1 
ATOM   893  C C    B GLU A 1 62  ? 18.52934 -7.11260  7.86424  0.496 16.70715  ? 59  GLU A C    1 
ATOM   894  O O    A GLU A 1 62  ? 18.73988 -7.05458  6.64814  0.504 24.67923  ? 59  GLU A O    1 
ATOM   895  O O    B GLU A 1 62  ? 18.71571 -7.07144  6.65069  0.496 24.67978  ? 59  GLU A O    1 
ATOM   896  C CB   A GLU A 1 62  ? 17.28955 -9.00385  8.98260  0.504 23.99985  ? 59  GLU A CB   1 
ATOM   897  C CB   B GLU A 1 62  ? 17.26018 -8.98107  9.03265  0.496 23.98638  ? 59  GLU A CB   1 
ATOM   898  C CG   A GLU A 1 62  ? 16.54431 -9.65332  7.83483  0.504 28.75034  ? 59  GLU A CG   1 
ATOM   899  C CG   B GLU A 1 62  ? 16.56795 -8.16356  10.14612 0.496 21.95193  ? 59  GLU A CG   1 
ATOM   900  C CD   A GLU A 1 62  ? 15.10216 -9.97466  8.18307  0.504 32.22618  ? 59  GLU A CD   1 
ATOM   901  C CD   B GLU A 1 62  ? 15.26928 -8.76397  10.67243 0.496 36.52717  ? 59  GLU A CD   1 
ATOM   902  O OE1  A GLU A 1 62  ? 14.73157 -9.95611  9.38022  0.504 35.87258  ? 59  GLU A OE1  1 
ATOM   903  O OE1  B GLU A 1 62  ? 14.78482 -9.75158  10.06452 0.496 38.00581  ? 59  GLU A OE1  1 
ATOM   904  O OE2  A GLU A 1 62  ? 14.33168 -10.23216 7.23890  0.504 38.78629  ? 59  GLU A OE2  1 
ATOM   905  O OE2  B GLU A 1 62  ? 14.75995 -8.24304  11.70529 0.496 31.68275  ? 59  GLU A OE2  1 
ATOM   906  H H    A GLU A 1 62  ? 19.09347 -8.52324  10.55508 0.504 28.53774  ? 59  GLU A H    1 
ATOM   907  H H    B GLU A 1 62  ? 19.10251 -8.53394  10.56200 0.496 28.52984  ? 59  GLU A H    1 
ATOM   908  H HA   A GLU A 1 62  ? 19.08836 -9.06692  8.01186  0.504 31.79430  ? 59  GLU A HA   1 
ATOM   909  H HA   B GLU A 1 62  ? 19.04651 -9.07758  8.02696  0.496 31.78118  ? 59  GLU A HA   1 
ATOM   910  H HB2  A GLU A 1 62  ? 17.40941 -9.67648  9.67115  0.504 28.79983  ? 59  GLU A HB2  1 
ATOM   911  H HB2  B GLU A 1 62  ? 16.68176 -8.96993  8.25405  0.496 28.78367  ? 59  GLU A HB2  1 
ATOM   912  H HB3  A GLU A 1 62  ? 16.73692 -8.28062  9.31794  0.504 28.79983  ? 59  GLU A HB3  1 
ATOM   913  H HB3  B GLU A 1 62  ? 17.36558 -9.88997  9.35466  0.496 28.78367  ? 59  GLU A HB3  1 
ATOM   914  H HG2  A GLU A 1 62  ? 16.54285 -9.04917  7.07596  0.504 34.50043  ? 59  GLU A HG2  1 
ATOM   915  H HG2  B GLU A 1 62  ? 17.17798 -8.08771  10.89646 0.496 26.34233  ? 59  GLU A HG2  1 
ATOM   916  H HG3  A GLU A 1 62  ? 16.98827 -10.48257 7.59785  0.504 34.50043  ? 59  GLU A HG3  1 
ATOM   917  H HG3  B GLU A 1 62  ? 16.36025 -7.28270  9.79706  0.496 26.34233  ? 59  GLU A HG3  1 
ATOM   918  N N    . ASP A 1 63  ? 18.25590 -6.01331  8.56001  1.000 20.23879  ? 60  ASP A N    1 
ATOM   919  C CA   . ASP A 1 63  ? 18.13809 -4.71092  7.88668  1.000 19.75747  ? 60  ASP A CA   1 
ATOM   920  C C    . ASP A 1 63  ? 19.48289 -4.23241  7.36442  1.000 26.84121  ? 60  ASP A C    1 
ATOM   921  O O    . ASP A 1 63  ? 19.59750 -3.67374  6.26274  1.000 23.58505  ? 60  ASP A O    1 
ATOM   922  C CB   . ASP A 1 63  ? 17.57877 -3.65401  8.84651  1.000 25.05176  ? 60  ASP A CB   1 
ATOM   923  C CG   . ASP A 1 63  ? 16.10885 -3.87117  9.16173  1.000 20.60026  ? 60  ASP A CG   1 
ATOM   924  O OD1  . ASP A 1 63  ? 15.48147 -4.64610  8.43525  1.000 32.97582  ? 60  ASP A OD1  1 
ATOM   925  O OD2  . ASP A 1 63  ? 15.56834 -3.24593  10.10664 1.000 41.44995  ? 60  ASP A OD2  1 
ATOM   926  H H    A ASP A 1 63  ? 18.12612 -5.99224  9.40990  0.504 24.28656  ? 60  ASP A H    1 
ATOM   927  H H    B ASP A 1 63  ? 18.13459 -5.98757  9.41102  0.496 24.28656  ? 60  ASP A H    1 
ATOM   928  H HA   . ASP A 1 63  ? 17.52447 -4.82154  7.14362  1.000 23.70897  ? 60  ASP A HA   1 
ATOM   929  H HB2  . ASP A 1 63  ? 18.07344 -3.68983  9.68012  1.000 30.06212  ? 60  ASP A HB2  1 
ATOM   930  H HB3  . ASP A 1 63  ? 17.67315 -2.77738  8.44213  1.000 30.06212  ? 60  ASP A HB3  1 
ATOM   931  N N    . ALA A 1 64  ? 20.50564 -4.34209  8.20151  1.000 26.15119  ? 61  ALA A N    1 
ATOM   932  C CA   . ALA A 1 64  ? 21.80061 -3.82798  7.79970  1.000 23.23189  ? 61  ALA A CA   1 
ATOM   933  C C    . ALA A 1 64  ? 22.35077 -4.58752  6.60120  1.000 15.18482  ? 61  ALA A C    1 
ATOM   934  O O    . ALA A 1 64  ? 23.13109 -4.04150  5.83262  1.000 22.76634  ? 61  ALA A O    1 
ATOM   935  C CB   . ALA A 1 64  ? 22.79501 -3.92866  8.95165  1.000 25.14754  ? 61  ALA A CB   1 
ATOM   936  H H    . ALA A 1 64  ? 20.47549 -4.69914  8.98331  1.000 31.38144  ? 61  ALA A H    1 
ATOM   937  H HA   . ALA A 1 64  ? 21.69528 -2.89315  7.56327  1.000 27.87829  ? 61  ALA A HA   1 
ATOM   938  H HB1  . ALA A 1 64  ? 23.65122 -3.57717  8.66137  1.000 30.17706  ? 61  ALA A HB1  1 
ATOM   939  H HB2  . ALA A 1 64  ? 22.46245 -3.41170  9.70202  1.000 30.17706  ? 61  ALA A HB2  1 
ATOM   940  H HB3  . ALA A 1 64  ? 22.88910 -4.85966  9.20716  1.000 30.17706  ? 61  ALA A HB3  1 
ATOM   941  N N    . LYS A 1 65  ? 22.03867 -5.87170  6.49833  1.000 18.79956  ? 62  LYS A N    1 
ATOM   942  C CA   . LYS A 1 65  ? 22.44265 -6.62883  5.31594  1.000 23.66991  ? 62  LYS A CA   1 
ATOM   943  C C    . LYS A 1 65  ? 22.00645 -5.93632  4.01594  1.000 40.12763  ? 62  LYS A C    1 
ATOM   944  O O    . LYS A 1 65  ? 22.71653 -6.00838  3.00335  1.000 37.84644  ? 62  LYS A O    1 
ATOM   945  C CB   . LYS A 1 65  ? 21.84912 -8.03801  5.42944  1.000 37.57903  ? 62  LYS A CB   1 
ATOM   946  C CG   . LYS A 1 65  ? 22.23011 -9.04459  4.34334  1.000 47.85342  ? 62  LYS A CG   1 
ATOM   947  C CD   . LYS A 1 65  ? 21.23116 -10.28038 4.25849  1.000 80.57442  ? 62  LYS A CD   1 
ATOM   948  C CE   . LYS A 1 65  ? 21.10638 -11.14458 5.55183  1.000 61.17729  ? 62  LYS A CE   1 
ATOM   949  N NZ   . LYS A 1 65  ? 22.32554 -12.03688 5.74486  1.000 77.30596  ? 62  LYS A NZ   1 
ATOM   950  H H    . LYS A 1 65  ? 21.60206 -6.32330  7.08572  1.000 22.55949  ? 62  LYS A H    1 
ATOM   951  H HA   . LYS A 1 65  ? 23.40895 -6.70215  5.27378  1.000 28.40391  ? 62  LYS A HA   1 
ATOM   952  H HB2  . LYS A 1 65  ? 22.13533 -8.41530  6.27598  1.000 45.09485  ? 62  LYS A HB2  1 
ATOM   953  H HB3  . LYS A 1 65  ? 20.88264 -7.95727  5.41205  1.000 45.09485  ? 62  LYS A HB3  1 
ATOM   954  H HG2  . LYS A 1 65  ? 22.22415 -8.59699  3.48281  1.000 57.42412  ? 62  LYS A HG2  1 
ATOM   955  H HG3  . LYS A 1 65  ? 23.11666 -9.39045  4.53126  1.000 57.42412  ? 62  LYS A HG3  1 
ATOM   956  H HD2  . LYS A 1 65  ? 20.34535 -9.94241  4.05352  1.000 96.68932  ? 62  LYS A HD2  1 
ATOM   957  H HD3  . LYS A 1 65  ? 21.53409 -10.86871 3.54926  1.000 96.68932  ? 62  LYS A HD3  1 
ATOM   958  H HE2  . LYS A 1 65  ? 21.03043 -10.56050 6.32253  1.000 73.41277  ? 62  LYS A HE2  1 
ATOM   959  H HE3  . LYS A 1 65  ? 20.32129 -11.71042 5.48574  1.000 73.41277  ? 62  LYS A HE3  1 
ATOM   960  H HZ1  . LYS A 1 65  ? 22.24816 -12.49843 6.50188  1.000 92.76717  ? 62  LYS A HZ1  1 
ATOM   961  H HZ2  . LYS A 1 65  ? 22.39629 -12.60687 5.06500  1.000 92.76717  ? 62  LYS A HZ2  1 
ATOM   962  H HZ3  . LYS A 1 65  ? 23.06314 -11.54033 5.78342  1.000 92.76717  ? 62  LYS A HZ3  1 
ATOM   963  N N    . LYS A 1 66  ? 20.86626 -5.24491  4.03158  1.000 37.28749  ? 63  LYS A N    1 
ATOM   964  C CA   . LYS A 1 66  ? 20.31456 -4.67138  2.81117  1.000 49.42312  ? 63  LYS A CA   1 
ATOM   965  C C    . LYS A 1 66  ? 20.95712 -3.33910  2.43671  1.000 43.18323  ? 63  LYS A C    1 
ATOM   966  O O    . LYS A 1 66  ? 20.72194 -2.84517  1.32746  1.000 51.26126  ? 63  LYS A O    1 
ATOM   967  C CB   . LYS A 1 66  ? 18.78214 -4.50160  2.96595  1.000 38.32763  ? 63  LYS A CB   1 
ATOM   968  C CG   . LYS A 1 66  ? 17.96691 -5.79497  3.37817  1.000 49.01058  ? 63  LYS A CG   1 
ATOM   969  C CD   . LYS A 1 66  ? 16.49747 -5.49708  3.85966  1.000 55.22225  ? 63  LYS A CD   1 
ATOM   970  C CE   . LYS A 1 66  ? 15.77139 -6.78163  4.38432  1.000 66.38674  ? 63  LYS A CE   1 
ATOM   971  N NZ   . LYS A 1 66  ? 15.57833 -7.81384  3.30880  1.000 70.75055  ? 63  LYS A NZ   1 
ATOM   972  H H    . LYS A 1 66  ? 20.39643 -5.09590  4.73632  1.000 44.74500  ? 63  LYS A H    1 
ATOM   973  H HA   . LYS A 1 66  ? 20.47223 -5.28099  2.07332  1.000 59.30776  ? 63  LYS A HA   1 
ATOM   974  H HB2  . LYS A 1 66  ? 18.62070 -3.83341  3.65032  1.000 45.99318  ? 63  LYS A HB2  1 
ATOM   975  H HB3  . LYS A 1 66  ? 18.42522 -4.19915  2.11622  1.000 45.99318  ? 63  LYS A HB3  1 
ATOM   976  H HG2  . LYS A 1 66  ? 17.91140 -6.38639  2.61134  1.000 58.81271  ? 63  LYS A HG2  1 
ATOM   977  H HG3  . LYS A 1 66  ? 18.43119 -6.23774  4.10570  1.000 58.81271  ? 63  LYS A HG3  1 
ATOM   978  H HD2  . LYS A 1 66  ? 16.52432 -4.84993  4.58173  1.000 66.26672  ? 63  LYS A HD2  1 
ATOM   979  H HD3  . LYS A 1 66  ? 15.98459 -5.14347  3.11614  1.000 66.26672  ? 63  LYS A HD3  1 
ATOM   980  H HE2  . LYS A 1 66  ? 16.30274 -7.17987  5.09141  1.000 79.66411  ? 63  LYS A HE2  1 
ATOM   981  H HE3  . LYS A 1 66  ? 14.89725 -6.53513  4.72492  1.000 79.66411  ? 63  LYS A HE3  1 
ATOM   982  H HZ1  . LYS A 1 66  ? 16.36864 -8.09740  3.01365  1.000 84.90068  ? 63  LYS A HZ1  1 
ATOM   983  H HZ2  . LYS A 1 66  ? 15.12436 -8.50815  3.63121  1.000 84.90068  ? 63  LYS A HZ2  1 
ATOM   984  H HZ3  . LYS A 1 66  ? 15.12471 -7.46307  2.62815  1.000 84.90068  ? 63  LYS A HZ3  1 
ATOM   985  N N    . GLU A 1 67  ? 21.73251 -2.72761  3.33004  1.000 38.76302  ? 64  GLU A N    1 
ATOM   986  C CA   . GLU A 1 67  ? 22.33738 -1.41809  3.07972  1.000 26.72587  ? 64  GLU A CA   1 
ATOM   987  C C    . GLU A 1 67  ? 23.83113 -1.53961  2.85481  1.000 36.00303  ? 64  GLU A C    1 
ATOM   988  O O    . GLU A 1 67  ? 24.59841 -0.58051  3.05004  1.000 47.65832  ? 64  GLU A O    1 
ATOM   989  C CB   . GLU A 1 67  ? 22.00383 -0.47522  4.22809  1.000 35.14382  ? 64  GLU A CB   1 
ATOM   990  C CG   . GLU A 1 67  ? 20.49502 -0.35173  4.40186  1.000 50.38732  ? 64  GLU A CG   1 
ATOM   991  C CD   . GLU A 1 67  ? 20.11043 0.60868   5.49712  1.000 66.64901  ? 64  GLU A CD   1 
ATOM   992  O OE1  . GLU A 1 67  ? 20.46896 0.35160   6.67341  1.000 69.36536  ? 64  GLU A OE1  1 
ATOM   993  O OE2  . GLU A 1 67  ? 19.45984 1.62598   5.16450  1.000 71.02870  ? 64  GLU A OE2  1 
ATOM   994  H H    A GLU A 1 67  ? 21.92665 -3.05554  4.10100  0.590 46.51564  ? 64  GLU A H    1 
ATOM   995  H H    B GLU A 1 67  ? 21.92665 -3.05554  4.10100  0.410 46.51564  ? 64  GLU A H    1 
ATOM   996  H HA   . GLU A 1 67  ? 21.96420 -1.02278  2.27637  1.000 32.07106  ? 64  GLU A HA   1 
ATOM   997  H HB2  . GLU A 1 67  ? 22.38254 -0.82121  5.05135  1.000 42.17260  ? 64  GLU A HB2  1 
ATOM   998  H HB3  . GLU A 1 67  ? 22.36642 0.40463   4.04019  1.000 42.17260  ? 64  GLU A HB3  1 
ATOM   999  H HG2  . GLU A 1 67  ? 20.10657 -0.03187  3.57258  1.000 60.46480  ? 64  GLU A HG2  1 
ATOM   1000 H HG3  . GLU A 1 67  ? 20.13033 -1.22245  4.62491  1.000 60.46480  ? 64  GLU A HG3  1 
ATOM   1001 N N    . GLY A 1 68  ? 24.25316 -2.71369  2.42368  1.000 28.88373  ? 65  GLY A N    1 
ATOM   1002 C CA   . GLY A 1 68  ? 25.62626 -2.91251  2.03871  1.000 41.45693  ? 65  GLY A CA   1 
ATOM   1003 C C    . GLY A 1 68  ? 25.94177 -2.20833  0.73606  1.000 50.41957  ? 65  GLY A C    1 
ATOM   1004 O O    . GLY A 1 68  ? 25.17250 -1.35296  0.26058  1.000 66.80609  ? 65  GLY A O    1 
ATOM   1005 H H    . GLY A 1 68  ? 23.75722 -3.41201  2.34627  1.000 34.66049  ? 65  GLY A H    1 
ATOM   1006 H HA2  . GLY A 1 68  ? 26.21122 -2.56347  2.72929  1.000 49.74833  ? 65  GLY A HA2  1 
ATOM   1007 H HA3  . GLY A 1 68  ? 25.79879 -3.86062  1.92819  1.000 49.74833  ? 65  GLY A HA3  1 
ATOM   1008 N N    . PRO A 1 69  ? 27.12550 -2.50784  0.15856  1.000 51.35185  ? 66  PRO A N    1 
ATOM   1009 C CA   . PRO A 1 69  ? 28.21021 -3.29952  0.74612  1.000 35.16701  ? 66  PRO A CA   1 
ATOM   1010 C C    . PRO A 1 69  ? 29.03371 -2.43323  1.68463  1.000 23.21220  ? 66  PRO A C    1 
ATOM   1011 O O    . PRO A 1 69  ? 29.04040 -1.17820  1.65025  1.000 35.15235  ? 66  PRO A O    1 
ATOM   1012 C CB   . PRO A 1 69  ? 29.02210 -3.74148  -0.48353 1.000 44.44204  ? 66  PRO A CB   1 
ATOM   1013 C CG   . PRO A 1 69  ? 28.95562 -2.47998  -1.39979 1.000 47.61974  ? 66  PRO A CG   1 
ATOM   1014 C CD   . PRO A 1 69  ? 27.56740 -1.85532  -1.10455 1.000 56.93807  ? 66  PRO A CD   1 
ATOM   1015 H HA   . PRO A 1 69  ? 27.87566 -4.08866  1.20025  1.000 42.20043  ? 66  PRO A HA   1 
ATOM   1016 H HB2  . PRO A 1 69  ? 29.93490 -3.95146  -0.23133 1.000 53.33047  ? 66  PRO A HB2  1 
ATOM   1017 H HB3  . PRO A 1 69  ? 28.60913 -4.51105  -0.90557 1.000 53.33047  ? 66  PRO A HB3  1 
ATOM   1018 H HG2  . PRO A 1 69  ? 29.67008 -1.86518  -1.17072 1.000 57.14370  ? 66  PRO A HG2  1 
ATOM   1019 H HG3  . PRO A 1 69  ? 29.02893 -2.74167  -2.33094 1.000 57.14370  ? 66  PRO A HG3  1 
ATOM   1020 H HD2  . PRO A 1 69  ? 27.64443 -0.89600  -0.98341 1.000 68.32570  ? 66  PRO A HD2  1 
ATOM   1021 H HD3  . PRO A 1 69  ? 26.94640 -2.05008  -1.82381 1.000 68.32570  ? 66  PRO A HD3  1 
ATOM   1022 N N    . TYR A 1 70  ? 29.80040 -3.18545  2.47671  1.000 20.55790  ? 67  TYR A N    1 
ATOM   1023 C CA   . TYR A 1 70  ? 30.69792 -2.64407  3.48486  1.000 16.59842  ? 67  TYR A CA   1 
ATOM   1024 C C    . TYR A 1 70  ? 32.15221 -2.84575  3.11035  1.000 8.40466   ? 67  TYR A C    1 
ATOM   1025 O O    . TYR A 1 70  ? 32.54836 -3.86838  2.55261  1.000 14.37109  ? 67  TYR A O    1 
ATOM   1026 C CB   . TYR A 1 70  ? 30.36284 -3.27457  4.83502  1.000 12.73793  ? 67  TYR A CB   1 
ATOM   1027 C CG   . TYR A 1 70  ? 28.95199 -2.95715  5.29211  1.000 11.65255  ? 67  TYR A CG   1 
ATOM   1028 C CD1  . TYR A 1 70  ? 28.65135 -1.78551  5.97625  1.000 11.43770  ? 67  TYR A CD1  1 
ATOM   1029 C CD2  . TYR A 1 70  ? 27.91441 -3.79598  5.02447  1.000 13.66747  ? 67  TYR A CD2  1 
ATOM   1030 C CE1  . TYR A 1 70  ? 27.33069 -1.49020  6.38759  1.000 13.29252  ? 67  TYR A CE1  1 
ATOM   1031 C CE2  . TYR A 1 70  ? 26.62936 -3.51539  5.44092  1.000 13.94253  ? 67  TYR A CE2  1 
ATOM   1032 C CZ   . TYR A 1 70  ? 26.33417 -2.36135  6.10780  1.000 20.91324  ? 67  TYR A CZ   1 
ATOM   1033 O OH   . TYR A 1 70  ? 25.04753 -2.09373  6.50355  1.000 24.56219  ? 67  TYR A OH   1 
ATOM   1034 H H    . TYR A 1 70  ? 29.81471 -4.04469  2.44339  1.000 24.66950  ? 67  TYR A H    1 
ATOM   1035 H HA   . TYR A 1 70  ? 30.59221 -1.68208  3.55048  1.000 19.91812  ? 67  TYR A HA   1 
ATOM   1036 H HB2  . TYR A 1 70  ? 30.44649 -4.23832  4.76360  1.000 15.28553  ? 67  TYR A HB2  1 
ATOM   1037 H HB3  . TYR A 1 70  ? 30.97908 -2.93671  5.50360  1.000 15.28553  ? 67  TYR A HB3  1 
ATOM   1038 H HD1  . TYR A 1 70  ? 29.33312 -1.18266  6.16773  1.000 13.72525  ? 67  TYR A HD1  1 
ATOM   1039 H HD2  . TYR A 1 70  ? 28.07568 -4.57855  4.54857  1.000 16.40098  ? 67  TYR A HD2  1 
ATOM   1040 H HE1  . TYR A 1 70  ? 27.14860 -0.70252  6.84727  1.000 15.95104  ? 67  TYR A HE1  1 
ATOM   1041 H HE2  . TYR A 1 70  ? 25.94997 -4.12523  5.26361  1.000 16.73105  ? 67  TYR A HE2  1 
ATOM   1042 H HH   . TYR A 1 70  ? 24.53689 -2.71443  6.25948  1.000 29.47464  ? 67  TYR A HH   1 
ATOM   1043 N N    . ASP A 1 71  ? 32.94414 -1.83599  3.40994  1.000 5.91570   ? 68  ASP A N    1 
ATOM   1044 C CA   . ASP A 1 71  ? 34.35677 -1.92667  3.19287  1.000 10.98667  ? 68  ASP A CA   1 
ATOM   1045 C C    . ASP A 1 71  ? 35.03949 -2.82178  4.21034  1.000 15.56611  ? 68  ASP A C    1 
ATOM   1046 O O    . ASP A 1 71  ? 36.09691 -3.37566  3.90045  1.000 13.59741  ? 68  ASP A O    1 
ATOM   1047 C CB   . ASP A 1 71  ? 34.90807 -0.53612  3.19867  1.000 11.15179  ? 68  ASP A CB   1 
ATOM   1048 C CG   . ASP A 1 71  ? 34.16068 0.34866   2.22108  1.000 13.43614  ? 68  ASP A CG   1 
ATOM   1049 O OD1  . ASP A 1 71  ? 34.41582 0.11751   1.03935  1.000 18.22651  ? 68  ASP A OD1  1 
ATOM   1050 O OD2  . ASP A 1 71  ? 33.31564 1.20542   2.58893  1.000 14.76139  ? 68  ASP A OD2  1 
ATOM   1051 H H    . ASP A 1 71  ? 32.68050 -1.08737  3.74109  1.000 7.09886   ? 68  ASP A H    1 
ATOM   1052 H HA   . ASP A 1 71  ? 34.55883 -2.31853  2.32886  1.000 13.18402  ? 68  ASP A HA   1 
ATOM   1053 H HB2  . ASP A 1 71  ? 34.81825 -0.15696  4.08697  1.000 13.38217  ? 68  ASP A HB2  1 
ATOM   1054 H HB3  . ASP A 1 71  ? 35.84279 -0.55837  2.94040  1.000 13.38217  ? 68  ASP A HB3  1 
ATOM   1055 N N    . VAL A 1 72  ? 34.47406 -2.97293  5.40065  1.000 7.58732   ? 69  VAL A N    1 
ATOM   1056 C CA   . VAL A 1 72  ? 35.03992 -3.89764  6.37574  1.000 5.11725   ? 69  VAL A CA   1 
ATOM   1057 C C    . VAL A 1 72  ? 33.89597 -4.53049  7.15857  1.000 9.48019   ? 69  VAL A C    1 
ATOM   1058 O O    . VAL A 1 72  ? 32.90370 -3.86857  7.48414  1.000 8.58959   ? 69  VAL A O    1 
ATOM   1059 C CB   . VAL A 1 72  ? 36.02924 -3.22146  7.32701  1.000 5.19530   ? 69  VAL A CB   1 
ATOM   1060 C CG1  . VAL A 1 72  ? 35.36421 -2.05048  8.11128  1.000 7.80445   ? 69  VAL A CG1  1 
ATOM   1061 C CG2  . VAL A 1 72  ? 36.66080 -4.29100  8.26932  1.000 8.88992   ? 69  VAL A CG2  1 
ATOM   1062 H H    . VAL A 1 72  ? 33.76980 -2.55616  5.66509  1.000 9.10480   ? 69  VAL A H    1 
ATOM   1063 H HA   . VAL A 1 72  ? 35.51734 -4.58855  5.89033  1.000 6.14072   ? 69  VAL A HA   1 
ATOM   1064 H HB   . VAL A 1 72  ? 36.74608 -2.81698  6.81375  1.000 6.23437   ? 69  VAL A HB   1 
ATOM   1065 H HG11 . VAL A 1 72  ? 36.05249 -1.55381  8.58085  1.000 9.36535   ? 69  VAL A HG11 1 
ATOM   1066 H HG12 . VAL A 1 72  ? 34.90702 -1.46936  7.48345  1.000 9.36535   ? 69  VAL A HG12 1 
ATOM   1067 H HG13 . VAL A 1 72  ? 34.72883 -2.41639  8.74634  1.000 9.36535   ? 69  VAL A HG13 1 
ATOM   1068 H HG21 . VAL A 1 72  ? 37.40022 -3.88950  8.75197  1.000 10.66792  ? 69  VAL A HG21 1 
ATOM   1069 H HG22 . VAL A 1 72  ? 35.98607 -4.59902  8.89444  1.000 10.66792  ? 69  VAL A HG22 1 
ATOM   1070 H HG23 . VAL A 1 72  ? 36.97988 -5.03443  7.73415  1.000 10.66792  ? 69  VAL A HG23 1 
ATOM   1071 N N    . VAL A 1 73  ? 34.03301 -5.82376  7.45517  1.000 8.56210   ? 70  VAL A N    1 
ATOM   1072 C CA   . VAL A 1 73  ? 33.09758 -6.53097  8.31387  1.000 2.25849   ? 70  VAL A CA   1 
ATOM   1073 C C    . VAL A 1 73  ? 33.88876 -6.89315  9.55679  1.000 11.35694  ? 70  VAL A C    1 
ATOM   1074 O O    . VAL A 1 73  ? 34.99799 -7.43785  9.45419  1.000 5.48317   ? 70  VAL A O    1 
ATOM   1075 C CB   . VAL A 1 73  ? 32.53297 -7.79235  7.68275  1.000 9.33743   ? 70  VAL A CB   1 
ATOM   1076 C CG1  . VAL A 1 73  ? 31.71682 -8.52499  8.71394  1.000 6.24004   ? 70  VAL A CG1  1 
ATOM   1077 C CG2  . VAL A 1 73  ? 31.65734 -7.40711  6.54676  1.000 10.35395  ? 70  VAL A CG2  1 
ATOM   1078 H H    . VAL A 1 73  ? 34.67391 -6.31688  7.16246  1.000 10.27454  ? 70  VAL A H    1 
ATOM   1079 H HA   . VAL A 1 73  ? 32.34452 -5.95427  8.51689  1.000 2.71021   ? 70  VAL A HA   1 
ATOM   1080 H HB   . VAL A 1 73  ? 33.24712 -8.36610  7.36383  1.000 11.20494  ? 70  VAL A HB   1 
ATOM   1081 H HG11 . VAL A 1 73  ? 31.17016 -9.19132  8.26888  1.000 7.48806   ? 70  VAL A HG11 1 
ATOM   1082 H HG12 . VAL A 1 73  ? 32.31618 -8.95562  9.34340  1.000 7.48806   ? 70  VAL A HG12 1 
ATOM   1083 H HG13 . VAL A 1 73  ? 31.15047 -7.88912  9.17849  1.000 7.48806   ? 70  VAL A HG13 1 
ATOM   1084 H HG21 . VAL A 1 73  ? 31.30507 -8.21059  6.13296  1.000 12.42475  ? 70  VAL A HG21 1 
ATOM   1085 H HG22 . VAL A 1 73  ? 30.92898 -6.86043  6.88072  1.000 12.42475  ? 70  VAL A HG22 1 
ATOM   1086 H HG23 . VAL A 1 73  ? 32.17939 -6.90456  5.90193  1.000 12.42475  ? 70  VAL A HG23 1 
ATOM   1087 N N    . VAL A 1 74  ? 33.34773 -6.54310  10.71585 1.000 7.13576   ? 71  VAL A N    1 
ATOM   1088 C CA   . VAL A 1 74  ? 34.10820 -6.63581  11.96071 1.000 6.30951   ? 71  VAL A CA   1 
ATOM   1089 C C    . VAL A 1 74  ? 33.42028 -7.62794  12.87040 1.000 6.42018   ? 71  VAL A C    1 
ATOM   1090 O O    . VAL A 1 74  ? 32.23067 -7.47868  13.17491 1.000 8.62225   ? 71  VAL A O    1 
ATOM   1091 C CB   . VAL A 1 74  ? 34.23067 -5.25468  12.64160 1.000 5.49241   ? 71  VAL A CB   1 
ATOM   1092 C CG1  . VAL A 1 74  ? 34.97479 -5.37703  13.99245 1.000 9.34488   ? 71  VAL A CG1  1 
ATOM   1093 C CG2  . VAL A 1 74  ? 34.98606 -4.24246  11.77174 1.000 8.35991   ? 71  VAL A CG2  1 
ATOM   1094 H H    . VAL A 1 74  ? 32.54468 -6.24967  10.80859 1.000 8.56293   ? 71  VAL A H    1 
ATOM   1095 H HA   . VAL A 1 74  ? 34.99932 -6.97008  11.77347 1.000 7.57143   ? 71  VAL A HA   1 
ATOM   1096 H HB   . VAL A 1 74  ? 33.32668 -4.93175  12.78103 1.000 6.59091   ? 71  VAL A HB   1 
ATOM   1097 H HG11 . VAL A 1 74  ? 35.21931 -4.49009  14.29976 1.000 11.21387  ? 71  VAL A HG11 1 
ATOM   1098 H HG12 . VAL A 1 74  ? 34.38863 -5.80107  14.63860 1.000 11.21387  ? 71  VAL A HG12 1 
ATOM   1099 H HG13 . VAL A 1 74  ? 35.77209 -5.91487  13.86621 1.000 11.21387  ? 71  VAL A HG13 1 
ATOM   1100 H HG21 . VAL A 1 74  ? 35.02992 -3.39419  12.24016 1.000 10.03190  ? 71  VAL A HG21 1 
ATOM   1101 H HG22 . VAL A 1 74  ? 35.88190 -4.57529  11.60564 1.000 10.03190  ? 71  VAL A HG22 1 
ATOM   1102 H HG23 . VAL A 1 74  ? 34.51304 -4.13257  10.93206 1.000 10.03190  ? 71  VAL A HG23 1 
ATOM   1103 N N    . LEU A 1 75  ? 34.18664 -8.60667  13.33496 1.000 4.32192   ? 72  LEU A N    1 
ATOM   1104 C CA   . LEU A 1 75  ? 33.75127 -9.64788  14.25738 1.000 5.38579   ? 72  LEU A CA   1 
ATOM   1105 C C    . LEU A 1 75  ? 34.46387 -9.50961  15.60526 1.000 8.68137   ? 72  LEU A C    1 
ATOM   1106 O O    . LEU A 1 75  ? 35.65765 -9.85066  15.72777 1.000 6.95088   ? 72  LEU A O    1 
ATOM   1107 C CB   . LEU A 1 75  ? 34.01304 -11.03872 13.66858 1.000 5.10866   ? 72  LEU A CB   1 
ATOM   1108 C CG   . LEU A 1 75  ? 33.62156 -11.36551 12.23892 1.000 9.70233   ? 72  LEU A CG   1 
ATOM   1109 C CD1  . LEU A 1 75  ? 34.14848 -12.75470 11.97708 1.000 19.19643  ? 72  LEU A CD1  1 
ATOM   1110 C CD2  . LEU A 1 75  ? 32.14837 -11.30117 12.35040 1.000 7.92194   ? 72  LEU A CD2  1 
ATOM   1111 H H    . LEU A 1 75  ? 35.01395 -8.69515  13.11743 1.000 5.18632   ? 72  LEU A H    1 
ATOM   1112 H HA   . LEU A 1 75  ? 32.79919 -9.53821  14.40708 1.000 6.46297   ? 72  LEU A HA   1 
ATOM   1113 H HB2  . LEU A 1 75  ? 34.96878 -11.19460 13.72481 1.000 6.13040   ? 72  LEU A HB2  1 
ATOM   1114 H HB3  . LEU A 1 75  ? 33.53961 -11.67582 14.22614 1.000 6.13040   ? 72  LEU A HB3  1 
ATOM   1115 H HG   . LEU A 1 75  ? 33.94869 -10.80691 11.51653 1.000 11.64282  ? 72  LEU A HG   1 
ATOM   1116 H HD11 . LEU A 1 75  ? 33.91347 -13.01641 11.07310 1.000 23.03573  ? 72  LEU A HD11 1 
ATOM   1117 H HD12 . LEU A 1 75  ? 35.11296 -12.75129 12.08029 1.000 23.03573  ? 72  LEU A HD12 1 
ATOM   1118 H HD13 . LEU A 1 75  ? 33.74988 -13.36878 12.61342 1.000 23.03573  ? 72  LEU A HD13 1 
ATOM   1119 H HD21 . LEU A 1 75  ? 31.75750 -11.48943 11.48284 1.000 9.50635   ? 72  LEU A HD21 1 
ATOM   1120 H HD22 . LEU A 1 75  ? 31.85151 -11.96043 12.99705 1.000 9.50635   ? 72  LEU A HD22 1 
ATOM   1121 H HD23 . LEU A 1 75  ? 31.89231 -10.41242 12.64275 1.000 9.50635   ? 72  LEU A HD23 1 
ATOM   1122 N N    . PRO A 1 76  ? 33.78400 -9.01640  16.63378 1.000 10.10514  ? 73  PRO A N    1 
ATOM   1123 C CA   . PRO A 1 76  ? 34.37526 -8.91954  17.96099 1.000 5.25572   ? 73  PRO A CA   1 
ATOM   1124 C C    . PRO A 1 76  ? 34.56459 -10.29943 18.54340 1.000 6.46268   ? 73  PRO A C    1 
ATOM   1125 O O    . PRO A 1 76  ? 34.03479 -11.26230 18.05123 1.000 1.95334   ? 73  PRO A O    1 
ATOM   1126 C CB   . PRO A 1 76  ? 33.31602 -8.15919  18.76964 1.000 5.24995   ? 73  PRO A CB   1 
ATOM   1127 C CG   . PRO A 1 76  ? 32.43800 -7.57937  17.82710 1.000 11.48238  ? 73  PRO A CG   1 
ATOM   1128 C CD   . PRO A 1 76  ? 32.47377 -8.37012  16.56217 1.000 4.56397   ? 73  PRO A CD   1 
ATOM   1129 H HA   . PRO A 1 76  ? 35.20854 -8.42349  17.93940 1.000 6.30688   ? 73  PRO A HA   1 
ATOM   1130 H HB2  . PRO A 1 76  ? 32.84024 -8.77850  19.34495 1.000 6.29996   ? 73  PRO A HB2  1 
ATOM   1131 H HB3  . PRO A 1 76  ? 33.74595 -7.47334  19.30413 1.000 6.29996   ? 73  PRO A HB3  1 
ATOM   1132 H HG2  . PRO A 1 76  ? 31.53987 -7.58311  18.19350 1.000 13.77887  ? 73  PRO A HG2  1 
ATOM   1133 H HG3  . PRO A 1 76  ? 32.72228 -6.66808  17.65492 1.000 13.77887  ? 73  PRO A HG3  1 
ATOM   1134 H HD2  . PRO A 1 76  ? 31.76111 -9.02784  16.54176 1.000 5.47678   ? 73  PRO A HD2  1 
ATOM   1135 H HD3  . PRO A 1 76  ? 32.41267 -7.79058  15.78673 1.000 5.47678   ? 73  PRO A HD3  1 
ATOM   1136 N N    . GLY A 1 77  ? 35.24472 -10.35871 19.69667 1.000 7.63016   ? 74  GLY A N    1 
ATOM   1137 C CA   . GLY A 1 77  ? 35.44380 -11.61350 20.35876 1.000 2.44277   ? 74  GLY A CA   1 
ATOM   1138 C C    . GLY A 1 77  ? 34.46553 -11.81932 21.48172 1.000 9.29463   ? 74  GLY A C    1 
ATOM   1139 O O    . GLY A 1 77  ? 33.32421 -11.34906 21.43888 1.000 5.13320   ? 74  GLY A O    1 
ATOM   1140 H H    A GLY A 1 77  ? 35.58986 -9.67971  20.09596 0.650 9.15621   ? 74  GLY A H    1 
ATOM   1141 H H    B GLY A 1 77  ? 35.58986 -9.67971  20.09596 0.350 9.15621   ? 74  GLY A H    1 
ATOM   1142 H HA2  . GLY A 1 77  ? 35.33532 -12.33577 19.72043 1.000 2.93134   ? 74  GLY A HA2  1 
ATOM   1143 H HA3  . GLY A 1 77  ? 36.34194 -11.64674 20.72362 1.000 2.93134   ? 74  GLY A HA3  1 
ATOM   1144 N N    . GLY A 1 78  ? 34.97117 -12.41827 22.55415 1.000 6.00779   ? 75  GLY A N    1 
ATOM   1145 C CA   . GLY A 1 78  ? 34.14942 -12.96403 23.61452 1.000 3.44211   ? 75  GLY A CA   1 
ATOM   1146 C C    . GLY A 1 78  ? 33.76880 -14.37820 23.18484 1.000 7.92340   ? 75  GLY A C    1 
ATOM   1147 O O    . GLY A 1 78  ? 33.31457 -14.58813 22.05629 1.000 7.51484   ? 75  GLY A O    1 
ATOM   1148 H H    . GLY A 1 78  ? 35.81373 -12.52234 22.69152 1.000 7.20937   ? 75  GLY A H    1 
ATOM   1149 H HA2  . GLY A 1 78  ? 34.64177 -12.99376 24.44974 1.000 4.13055   ? 75  GLY A HA2  1 
ATOM   1150 H HA3  . GLY A 1 78  ? 33.34934 -12.42977 23.73841 1.000 4.13055   ? 75  GLY A HA3  1 
ATOM   1151 N N    . ASN A 1 79  ? 34.02501 -15.33632 24.06838 1.000 9.37420   ? 76  ASN A N    1 
ATOM   1152 C CA   . ASN A 1 79  ? 33.82092 -16.74686 23.75945 1.000 9.86890   ? 76  ASN A CA   1 
ATOM   1153 C C    . ASN A 1 79  ? 32.38344 -17.06576 23.34405 1.000 9.75904   ? 76  ASN A C    1 
ATOM   1154 O O    . ASN A 1 79  ? 32.17258 -17.73845 22.32912 1.000 9.92864   ? 76  ASN A O    1 
ATOM   1155 C CB   . ASN A 1 79  ? 34.26496 -17.58494 24.94943 1.000 17.97035  ? 76  ASN A CB   1 
ATOM   1156 C CG   . ASN A 1 79  ? 35.76606 -17.75318 24.99721 1.000 30.58281  ? 76  ASN A CG   1 
ATOM   1157 O OD1  . ASN A 1 79  ? 36.45060 -17.56001 23.98091 1.000 40.55480  ? 76  ASN A OD1  1 
ATOM   1158 N ND2  . ASN A 1 79  ? 36.29589 -18.06013 26.16391 1.000 35.64191  ? 76  ASN A ND2  1 
ATOM   1159 H H    . ASN A 1 79  ? 34.32132 -15.19609 24.86345 1.000 11.24905  ? 76  ASN A H    1 
ATOM   1160 H HA   . ASN A 1 79  ? 34.37031 -16.97828 22.99427 1.000 11.84270  ? 76  ASN A HA   1 
ATOM   1161 H HB2  . ASN A 1 79  ? 33.98283 -17.14944 25.76897 1.000 21.56444  ? 76  ASN A HB2  1 
ATOM   1162 H HB3  . ASN A 1 79  ? 33.86340 -18.46567 24.88653 1.000 21.56444  ? 76  ASN A HB3  1 
ATOM   1163 H HD21 . ASN A 1 79  ? 37.14644 -18.16508 26.23567 1.000 42.77031  ? 76  ASN A HD21 1 
ATOM   1164 H HD22 . ASN A 1 79  ? 35.79115 -18.15551 26.85366 1.000 42.77031  ? 76  ASN A HD22 1 
ATOM   1165 N N    . LEU A 1 80  ? 31.38478 -16.64569 24.12412 1.000 2.14494   ? 77  LEU A N    1 
ATOM   1166 C CA   . LEU A 1 80  ? 29.99944 -16.93434 23.73352 1.000 10.86572  ? 77  LEU A CA   1 
ATOM   1167 C C    . LEU A 1 80  ? 29.59266 -16.10688 22.52603 1.000 9.84558   ? 77  LEU A C    1 
ATOM   1168 O O    . LEU A 1 80  ? 28.85021 -16.58814 21.66305 1.000 11.46723  ? 77  LEU A O    1 
ATOM   1169 C CB   . LEU A 1 80  ? 29.09794 -16.74362 24.94597 1.000 5.66039   ? 77  LEU A CB   1 
ATOM   1170 C CG   . LEU A 1 80  ? 29.48657 -17.58669 26.17900 1.000 17.05230  ? 77  LEU A CG   1 
ATOM   1171 C CD1  . LEU A 1 80  ? 28.45460 -17.25253 27.27117 1.000 44.69162  ? 77  LEU A CD1  1 
ATOM   1172 C CD2  . LEU A 1 80  ? 29.40612 -19.03778 25.81292 1.000 36.02795  ? 77  LEU A CD2  1 
ATOM   1173 H H    . LEU A 1 80  ? 31.47639 -16.20744 24.85838 1.000 2.57394   ? 77  LEU A H    1 
ATOM   1174 H HA   . LEU A 1 80  ? 29.89208 -17.85931 23.46185 1.000 13.03889  ? 77  LEU A HA   1 
ATOM   1175 H HB2  . LEU A 1 80  ? 29.12892 -15.81024 25.20817 1.000 6.79248   ? 77  LEU A HB2  1 
ATOM   1176 H HB3  . LEU A 1 80  ? 28.19286 -16.98857 24.69753 1.000 6.79248   ? 77  LEU A HB3  1 
ATOM   1177 H HG   . LEU A 1 80  ? 30.38583 -17.40348 26.49310 1.000 20.46278  ? 77  LEU A HG   1 
ATOM   1178 H HD11 . LEU A 1 80  ? 28.64234 -17.78840 28.05761 1.000 53.62996  ? 77  LEU A HD11 1 
ATOM   1179 H HD12 . LEU A 1 80  ? 28.52027 -16.30979 27.48987 1.000 53.62996  ? 77  LEU A HD12 1 
ATOM   1180 H HD13 . LEU A 1 80  ? 27.56602 -17.45373 26.93822 1.000 53.62996  ? 77  LEU A HD13 1 
ATOM   1181 H HD21 . LEU A 1 80  ? 30.15914 -19.26221 25.24416 1.000 43.23355  ? 77  LEU A HD21 1 
ATOM   1182 H HD22 . LEU A 1 80  ? 29.43361 -19.56995 26.62344 1.000 43.23355  ? 77  LEU A HD22 1 
ATOM   1183 H HD23 . LEU A 1 80  ? 28.57474 -19.19848 25.33974 1.000 43.23355  ? 77  LEU A HD23 1 
ATOM   1184 N N    . GLY A 1 81  ? 30.15438 -14.89998 22.37664 1.000 7.99686   ? 78  GLY A N    1 
ATOM   1185 C CA   . GLY A 1 81  ? 29.83955 -14.12581 21.18530 1.000 11.88960  ? 78  GLY A CA   1 
ATOM   1186 C C    . GLY A 1 81  ? 30.34827 -14.81300 19.92930 1.000 5.80274   ? 78  GLY A C    1 
ATOM   1187 O O    . GLY A 1 81  ? 29.62112 -14.93283 18.93657 1.000 8.20177   ? 78  GLY A O    1 
ATOM   1188 H H    . GLY A 1 81  ? 30.69719 -14.52735 22.92990 1.000 9.59625   ? 78  GLY A H    1 
ATOM   1189 H HA2  . GLY A 1 81  ? 28.87834 -14.01795 21.11220 1.000 14.26753  ? 78  GLY A HA2  1 
ATOM   1190 H HA3  . GLY A 1 81  ? 30.25173 -13.25000 21.24830 1.000 14.26753  ? 78  GLY A HA3  1 
ATOM   1191 N N    . ALA A 1 82  ? 31.57753 -15.31727 19.97786 1.000 6.92532   ? 79  ALA A N    1 
ATOM   1192 C CA   . ALA A 1 82  ? 32.14161 -15.92955 18.77484 1.000 12.07749  ? 79  ALA A CA   1 
ATOM   1193 C C    . ALA A 1 82  ? 31.36789 -17.17360 18.42217 1.000 11.84407  ? 79  ALA A C    1 
ATOM   1194 O O    . ALA A 1 82  ? 31.18809 -17.50001 17.23694 1.000 10.16323  ? 79  ALA A O    1 
ATOM   1195 C CB   . ALA A 1 82  ? 33.60884 -16.23603 18.98770 1.000 12.81964  ? 79  ALA A CB   1 
ATOM   1196 H H    . ALA A 1 82  ? 32.08983 -15.31899 20.66862 1.000 8.31040   ? 79  ALA A H    1 
ATOM   1197 H HA   . ALA A 1 82  ? 32.08490 -15.31086 18.02992 1.000 14.49300  ? 79  ALA A HA   1 
ATOM   1198 H HB1  . ALA A 1 82  ? 33.96398 -16.65213 18.18668 1.000 15.38358  ? 79  ALA A HB1  1 
ATOM   1199 H HB2  . ALA A 1 82  ? 34.08145 -15.40833 19.16783 1.000 15.38358  ? 79  ALA A HB2  1 
ATOM   1200 H HB3  . ALA A 1 82  ? 33.69926 -16.83941 19.74179 1.000 15.38358  ? 79  ALA A HB3  1 
ATOM   1201 N N    A GLN A 1 83  ? 30.89206 -17.89007 19.44324 0.436 9.59641   ? 80  GLN A N    1 
ATOM   1202 N N    B GLN A 1 83  ? 30.89028 -17.89339 19.44060 0.564 9.57942   ? 80  GLN A N    1 
ATOM   1203 C CA   A GLN A 1 83  ? 30.14094 -19.11925 19.20038 0.436 14.04161  ? 80  GLN A CA   1 
ATOM   1204 C CA   B GLN A 1 83  ? 30.13991 -19.11901 19.17254 0.564 14.04449  ? 80  GLN A CA   1 
ATOM   1205 C C    A GLN A 1 83  ? 28.80432 -18.81274 18.53446 0.436 14.94955  ? 80  GLN A C    1 
ATOM   1206 C C    B GLN A 1 83  ? 28.81059 -18.79625 18.50810 0.564 14.95081  ? 80  GLN A C    1 
ATOM   1207 O O    A GLN A 1 83  ? 28.36684 -19.54196 17.63057 0.436 11.92253  ? 80  GLN A O    1 
ATOM   1208 O O    B GLN A 1 83  ? 28.38563 -19.49755 17.57700 0.564 11.89380  ? 80  GLN A O    1 
ATOM   1209 C CB   A GLN A 1 83  ? 29.93210 -19.85342 20.52609 0.436 17.09721  ? 80  GLN A CB   1 
ATOM   1210 C CB   B GLN A 1 83  ? 29.92401 -19.88629 20.47432 0.564 17.10727  ? 80  GLN A CB   1 
ATOM   1211 C CG   A GLN A 1 83  ? 31.20256 -20.39232 21.20394 0.436 20.19250  ? 80  GLN A CG   1 
ATOM   1212 C CG   B GLN A 1 83  ? 29.18030 -21.23332 20.33048 0.564 20.13207  ? 80  GLN A CG   1 
ATOM   1213 C CD   A GLN A 1 83  ? 30.96594 -20.97889 22.62419 0.436 33.22696  ? 80  GLN A CD   1 
ATOM   1214 C CD   B GLN A 1 83  ? 28.68830 -21.80723 21.68900 0.564 41.35236  ? 80  GLN A CD   1 
ATOM   1215 O OE1  A GLN A 1 83  ? 29.83618 -21.26961 23.02267 0.436 45.68312  ? 80  GLN A OE1  1 
ATOM   1216 O OE1  B GLN A 1 83  ? 29.07298 -21.32935 22.76278 0.564 52.70072  ? 80  GLN A OE1  1 
ATOM   1217 N NE2  A GLN A 1 83  ? 32.04290 -21.12910 23.38643 0.436 24.56844  ? 80  GLN A NE2  1 
ATOM   1218 N NE2  B GLN A 1 83  ? 27.82068 -22.82074 21.63292 0.564 39.98700  ? 80  GLN A NE2  1 
ATOM   1219 H H    A GLN A 1 83  ? 30.98935 -17.68857 20.27362 0.436 11.51571  ? 80  GLN A H    1 
ATOM   1220 H H    B GLN A 1 83  ? 30.98461 -17.69882 20.27297 0.564 11.49533  ? 80  GLN A H    1 
ATOM   1221 H HA   A GLN A 1 83  ? 30.64404 -19.69915 18.60749 0.436 16.84995  ? 80  GLN A HA   1 
ATOM   1222 H HA   B GLN A 1 83  ? 30.64862 -19.68722 18.57316 0.564 16.85340  ? 80  GLN A HA   1 
ATOM   1223 H HB2  A GLN A 1 83  ? 29.51254 -19.24014 21.14959 0.436 20.51667  ? 80  GLN A HB2  1 
ATOM   1224 H HB2  B GLN A 1 83  ? 30.79126 -20.07459 20.86589 0.564 20.52874  ? 80  GLN A HB2  1 
ATOM   1225 H HB3  A GLN A 1 83  ? 29.34967 -20.61202 20.36420 0.436 20.51667  ? 80  GLN A HB3  1 
ATOM   1226 H HB3  B GLN A 1 83  ? 29.40277 -19.33024 21.07433 0.564 20.52874  ? 80  GLN A HB3  1 
ATOM   1227 H HG2  A GLN A 1 83  ? 31.57335 -21.09869 20.65217 0.436 24.23102  ? 80  GLN A HG2  1 
ATOM   1228 H HG2  B GLN A 1 83  ? 28.40470 -21.10544 19.76216 0.564 24.15850  ? 80  GLN A HG2  1 
ATOM   1229 H HG3  A GLN A 1 83  ? 31.84129 -19.66716 21.28805 0.436 24.23102  ? 80  GLN A HG3  1 
ATOM   1230 H HG3  B GLN A 1 83  ? 29.78021 -21.88299 19.93182 0.564 24.15850  ? 80  GLN A HG3  1 
ATOM   1231 H HE21 A GLN A 1 83  ? 32.81707 -20.90590 23.08571 0.436 29.48214  ? 80  GLN A HE21 1 
ATOM   1232 H HE21 B GLN A 1 83  ? 27.56185 -23.12353 20.87073 0.564 47.98441  ? 80  GLN A HE21 1 
ATOM   1233 H HE22 A GLN A 1 83  ? 31.96618 -21.44957 24.18079 0.436 29.48214  ? 80  GLN A HE22 1 
ATOM   1234 H HE22 B GLN A 1 83  ? 27.52074 -23.17068 22.35898 0.564 47.98441  ? 80  GLN A HE22 1 
ATOM   1235 N N    . ASN A 1 84  ? 28.14175 -17.73725 18.97459 1.000 12.99527  ? 81  ASN A N    1 
ATOM   1236 C CA   . ASN A 1 84  ? 26.93122 -17.28504 18.30510 1.000 13.67467  ? 81  ASN A CA   1 
ATOM   1237 C C    . ASN A 1 84  ? 27.24445 -16.86527 16.87957 1.000 10.44150  ? 81  ASN A C    1 
ATOM   1238 O O    . ASN A 1 84  ? 26.49034 -17.19206 15.96896 1.000 12.61157  ? 81  ASN A O    1 
ATOM   1239 C CB   . ASN A 1 84  ? 26.26841 -16.14463 19.10552 1.000 10.47541  ? 81  ASN A CB   1 
ATOM   1240 C CG   . ASN A 1 84  ? 25.52762 -16.66670 20.33917 1.000 21.92791  ? 81  ASN A CG   1 
ATOM   1241 O OD1  . ASN A 1 84  ? 24.78783 -17.62759 20.24601 1.000 21.86147  ? 81  ASN A OD1  1 
ATOM   1242 N ND2  . ASN A 1 84  ? 25.77177 -16.06636 21.49205 1.000 14.65400  ? 81  ASN A ND2  1 
ATOM   1243 H H    A ASN A 1 84  ? 28.37355 -17.26038 19.65169 0.436 15.59434  ? 81  ASN A H    1 
ATOM   1244 H H    B ASN A 1 84  ? 28.36695 -17.27499 19.66394 0.564 15.59434  ? 81  ASN A H    1 
ATOM   1245 H HA   . ASN A 1 84  ? 26.28687 -18.00922 18.26952 1.000 16.40962  ? 81  ASN A HA   1 
ATOM   1246 H HB2  . ASN A 1 84  ? 26.95206 -15.52383 19.40238 1.000 12.57050  ? 81  ASN A HB2  1 
ATOM   1247 H HB3  . ASN A 1 84  ? 25.62826 -15.68687 18.53845 1.000 12.57050  ? 81  ASN A HB3  1 
ATOM   1248 H HD21 . ASN A 1 84  ? 25.37471 -16.33133 22.20740 1.000 17.58481  ? 81  ASN A HD21 1 
ATOM   1249 H HD22 . ASN A 1 84  ? 26.32760 -15.41101 21.52637 1.000 17.58481  ? 81  ASN A HD22 1 
ATOM   1250 N N    . LEU A 1 85  ? 28.39025 -16.19508 16.64555 1.000 7.01062   ? 82  LEU A N    1 
ATOM   1251 C CA   . LEU A 1 85  ? 28.72666 -15.79332 15.27607 1.000 6.11375   ? 82  LEU A CA   1 
ATOM   1252 C C    . LEU A 1 85  ? 28.96437 -17.03247 14.41027 1.000 12.63224  ? 82  LEU A C    1 
ATOM   1253 O O    . LEU A 1 85  ? 28.58375 -17.06344 13.23694 1.000 13.62246  ? 82  LEU A O    1 
ATOM   1254 C CB   . LEU A 1 85  ? 29.96298 -14.92275 15.22882 1.000 9.43523   ? 82  LEU A CB   1 
ATOM   1255 C CG   . LEU A 1 85  ? 29.67514 -13.53739 15.80458 1.000 9.34502   ? 82  LEU A CG   1 
ATOM   1256 C CD1  . LEU A 1 85  ? 31.07818 -12.91737 15.84790 1.000 11.37145  ? 82  LEU A CD1  1 
ATOM   1257 C CD2  . LEU A 1 85  ? 28.72671 -12.76136 15.01063 1.000 13.29437  ? 82  LEU A CD2  1 
ATOM   1258 H H    . LEU A 1 85  ? 28.96599 -15.97115 17.24386 1.000 8.41276   ? 82  LEU A H    1 
ATOM   1259 H HA   . LEU A 1 85  ? 27.98627 -15.26962 14.93186 1.000 7.33652   ? 82  LEU A HA   1 
ATOM   1260 H HB2  . LEU A 1 85  ? 30.66760 -15.33481 15.75285 1.000 11.32229  ? 82  LEU A HB2  1 
ATOM   1261 H HB3  . LEU A 1 85  ? 30.25057 -14.82099 14.30804 1.000 11.32229  ? 82  LEU A HB3  1 
ATOM   1262 H HG   . LEU A 1 85  ? 29.23603 -13.55610 16.66930 1.000 11.21403  ? 82  LEU A HG   1 
ATOM   1263 H HD11 . LEU A 1 85  ? 31.00775 -11.99728 16.14687 1.000 13.64576  ? 82  LEU A HD11 1 
ATOM   1264 H HD12 . LEU A 1 85  ? 31.62861 -13.42446 16.46497 1.000 13.64576  ? 82  LEU A HD12 1 
ATOM   1265 H HD13 . LEU A 1 85  ? 31.46438 -12.94757 14.95862 1.000 13.64576  ? 82  LEU A HD13 1 
ATOM   1266 H HD21 . LEU A 1 85  ? 28.72075 -11.84603 15.33162 1.000 15.95326  ? 82  LEU A HD21 1 
ATOM   1267 H HD22 . LEU A 1 85  ? 29.00076 -12.78390 14.08042 1.000 15.95326  ? 82  LEU A HD22 1 
ATOM   1268 H HD23 . LEU A 1 85  ? 27.84324 -13.15063 15.10471 1.000 15.95326  ? 82  LEU A HD23 1 
ATOM   1269 N N    . SER A 1 86  ? 29.57998 -18.04432 15.00207 1.000 8.63195   ? 83  SER A N    1 
ATOM   1270 C CA   . SER A 1 86  ? 30.02448 -19.21355 14.27974 1.000 11.12884  ? 83  SER A CA   1 
ATOM   1271 C C    . SER A 1 86  ? 28.84907 -20.08054 13.88713 1.000 25.07390  ? 83  SER A C    1 
ATOM   1272 O O    . SER A 1 86  ? 28.93359 -20.86127 12.92521 1.000 16.66326  ? 83  SER A O    1 
ATOM   1273 C CB   . SER A 1 86  ? 30.96721 -20.06771 15.12754 1.000 10.08331  ? 83  SER A CB   1 
ATOM   1274 O OG   . SER A 1 86  ? 32.19900 -19.43300 15.39335 1.000 19.53618  ? 83  SER A OG   1 
ATOM   1275 H H    . SER A 1 86  ? 29.75564 -18.07651 15.84332 1.000 10.35835  ? 83  SER A H    1 
ATOM   1276 H HA   . SER A 1 86  ? 30.50451 -18.90704 13.49455 1.000 13.35462  ? 83  SER A HA   1 
ATOM   1277 H HB2  . SER A 1 86  ? 30.53162 -20.25861 15.97295 1.000 12.09999  ? 83  SER A HB2  1 
ATOM   1278 H HB3  . SER A 1 86  ? 31.14423 -20.89411 14.65149 1.000 12.09999  ? 83  SER A HB3  1 
ATOM   1279 H HG   . SER A 1 86  ? 32.06515 -18.68046 15.74173 1.000 23.44343  ? 83  SER A HG   1 
ATOM   1280 N N    . GLU A 1 87  ? 27.77521 -19.97190 14.63304 1.000 9.69975   ? 84  GLU A N    1 
ATOM   1281 C CA   . GLU A 1 87  ? 26.59119 -20.77038 14.38247 1.000 14.80772  ? 84  GLU A CA   1 
ATOM   1282 C C    . GLU A 1 87  ? 25.57379 -20.08017 13.48565 1.000 20.58013  ? 84  GLU A C    1 
ATOM   1283 O O    . GLU A 1 87  ? 24.55924 -20.68379 13.15562 1.000 25.92762  ? 84  GLU A O    1 
ATOM   1284 C CB   . GLU A 1 87  ? 25.92319 -21.13906 15.70580 1.000 26.48093  ? 84  GLU A CB   1 
ATOM   1285 C CG   . GLU A 1 87  ? 26.59715 -22.20434 16.60558 1.000 24.28595  ? 84  GLU A CG   1 
ATOM   1286 C CD   . GLU A 1 87  ? 25.93656 -22.29921 18.01725 1.000 51.89695  ? 84  GLU A CD   1 
ATOM   1287 O OE1  . GLU A 1 87  ? 24.76067 -21.85439 18.20026 1.000 52.60862  ? 84  GLU A OE1  1 
ATOM   1288 O OE2  . GLU A 1 87  ? 26.63255 -22.76681 18.96000 1.000 68.10105  ? 84  GLU A OE2  1 
ATOM   1289 H H    . GLU A 1 87  ? 27.70189 -19.43593 15.30158 1.000 11.63972  ? 84  GLU A H    1 
ATOM   1290 H HA   . GLU A 1 87  ? 26.86283 -21.58934 13.93928 1.000 17.76928  ? 84  GLU A HA   1 
ATOM   1291 H HB2  . GLU A 1 87  ? 25.86018 -20.33008 16.23729 1.000 31.77713  ? 84  GLU A HB2  1 
ATOM   1292 H HB3  . GLU A 1 87  ? 25.03526 -21.47251 15.50260 1.000 31.77713  ? 84  GLU A HB3  1 
ATOM   1293 H HG2  . GLU A 1 87  ? 26.52245 -23.07249 16.17939 1.000 29.14316  ? 84  GLU A HG2  1 
ATOM   1294 H HG3  . GLU A 1 87  ? 27.53147 -21.97290 16.72546 1.000 29.14316  ? 84  GLU A HG3  1 
ATOM   1295 N N    . SER A 1 88  ? 25.78093 -18.83486 13.08942 1.000 8.88217   ? 85  SER A N    1 
ATOM   1296 C CA   . SER A 1 88  ? 24.73422 -18.09634 12.42142 1.000 18.77780  ? 85  SER A CA   1 
ATOM   1297 C C    . SER A 1 88  ? 24.89400 -18.23007 10.91305 1.000 17.19895  ? 85  SER A C    1 
ATOM   1298 O O    . SER A 1 88  ? 25.94504 -17.89421 10.35914 1.000 11.89340  ? 85  SER A O    1 
ATOM   1299 C CB   . SER A 1 88  ? 24.77761 -16.63103 12.81595 1.000 22.87946  ? 85  SER A CB   1 
ATOM   1300 O OG   . SER A 1 88  ? 24.16268 -15.87751 11.78361 1.000 18.72990  ? 85  SER A OG   1 
ATOM   1301 H H    . SER A 1 88  ? 26.51618 -18.40199 13.19725 1.000 10.65862  ? 85  SER A H    1 
ATOM   1302 H HA   . SER A 1 88  ? 23.87558 -18.46751 12.67806 1.000 22.53337  ? 85  SER A HA   1 
ATOM   1303 H HB2  . SER A 1 88  ? 24.29384 -16.50214 13.64677 1.000 27.45537  ? 85  SER A HB2  1 
ATOM   1304 H HB3  . SER A 1 88  ? 25.69952 -16.34851 12.92159 1.000 27.45537  ? 85  SER A HB3  1 
ATOM   1305 H HG   . SER A 1 88  ? 24.16373 -15.06170 11.98375 1.000 22.47590  ? 85  SER A HG   1 
ATOM   1306 N N    . ALA A 1 89  ? 23.81954 -18.65032 10.22145 1.000 15.00026  ? 86  ALA A N    1 
ATOM   1307 C CA   . ALA A 1 89  ? 23.89473 -18.75048 8.74897  1.000 16.69721  ? 86  ALA A CA   1 
ATOM   1308 C C    . ALA A 1 89  ? 23.94853 -17.38203 8.07917  1.000 15.86978  ? 86  ALA A C    1 
ATOM   1309 O O    . ALA A 1 89  ? 24.52892 -17.23570 6.98165  1.000 14.79539  ? 86  ALA A O    1 
ATOM   1310 C CB   . ALA A 1 89  ? 22.69174 -19.54245 8.25134  1.000 25.92193  ? 86  ALA A CB   1 
ATOM   1311 H H    . ALA A 1 89  ? 23.06396 -18.87514 10.56520 1.000 18.00033  ? 86  ALA A H    1 
ATOM   1312 H HA   . ALA A 1 89  ? 24.70697 -19.21869 8.50005  1.000 20.03666  ? 86  ALA A HA   1 
ATOM   1313 H HB1  . ALA A 1 89  ? 22.73684 -19.61129 7.28483  1.000 31.10633  ? 86  ALA A HB1  1 
ATOM   1314 H HB2  . ALA A 1 89  ? 22.71078 -20.42777 8.64725  1.000 31.10633  ? 86  ALA A HB2  1 
ATOM   1315 H HB3  . ALA A 1 89  ? 21.87968 -19.08069 8.51253  1.000 31.10633  ? 86  ALA A HB3  1 
ATOM   1316 N N    . ALA A 1 90  ? 23.33672 -16.37995 8.70270  1.000 13.88435  ? 87  ALA A N    1 
ATOM   1317 C CA   . ALA A 1 90  ? 23.43939 -15.01687 8.19361  1.000 15.58956  ? 87  ALA A CA   1 
ATOM   1318 C C    . ALA A 1 90  ? 24.88245 -14.52839 8.22833  1.000 18.87752  ? 87  ALA A C    1 
ATOM   1319 O O    . ALA A 1 90  ? 25.34037 -13.87487 7.27908  1.000 16.74559  ? 87  ALA A O    1 
ATOM   1320 C CB   . ALA A 1 90  ? 22.50360 -14.12144 9.01980  1.000 20.26564  ? 87  ALA A CB   1 
ATOM   1321 H H    . ALA A 1 90  ? 22.86101 -16.46056 9.41460  1.000 16.66124  ? 87  ALA A H    1 
ATOM   1322 H HA   . ALA A 1 90  ? 23.15634 -14.97405 7.26681  1.000 18.70748  ? 87  ALA A HA   1 
ATOM   1323 H HB1  . ALA A 1 90  ? 22.56183 -13.21204 8.68736  1.000 24.31878  ? 87  ALA A HB1  1 
ATOM   1324 H HB2  . ALA A 1 90  ? 21.59458 -14.44828 8.93165  1.000 24.31878  ? 87  ALA A HB2  1 
ATOM   1325 H HB3  . ALA A 1 90  ? 22.77728 -14.15177 9.94989  1.000 24.31878  ? 87  ALA A HB3  1 
ATOM   1326 N N    . VAL A 1 91  ? 25.64291 -14.89393 9.26442  1.000 17.44131  ? 88  VAL A N    1 
ATOM   1327 C CA   . VAL A 1 91  ? 27.04341 -14.47549 9.25016  1.000 12.12726  ? 88  VAL A CA   1 
ATOM   1328 C C    . VAL A 1 91  ? 27.78408 -15.15433 8.11089  1.000 10.51799  ? 88  VAL A C    1 
ATOM   1329 O O    . VAL A 1 91  ? 28.58328 -14.52432 7.40691  1.000 13.08837  ? 88  VAL A O    1 
ATOM   1330 C CB   . VAL A 1 91  ? 27.68340 -14.75080 10.62215 1.000 15.63551  ? 88  VAL A CB   1 
ATOM   1331 C CG1  . VAL A 1 91  ? 29.10791 -14.33111 10.57112 1.000 10.15857  ? 88  VAL A CG1  1 
ATOM   1332 C CG2  . VAL A 1 91  ? 26.94963 -13.90903 11.68828 1.000 17.52461  ? 88  VAL A CG2  1 
ATOM   1333 H H    . VAL A 1 91  ? 25.38723 -15.35476 9.94403  1.000 20.92958  ? 88  VAL A H    1 
ATOM   1334 H HA   . VAL A 1 91  ? 27.09216 -13.51971 9.09203  1.000 14.55273  ? 88  VAL A HA   1 
ATOM   1335 H HB   . VAL A 1 91  ? 27.62302 -15.69226 10.84777 1.000 18.76263  ? 88  VAL A HB   1 
ATOM   1336 H HG11 . VAL A 1 91  ? 29.45532 -14.28220 11.47545 1.000 12.19030  ? 88  VAL A HG11 1 
ATOM   1337 H HG12 . VAL A 1 91  ? 29.61099 -14.98292 10.05832 1.000 12.19030  ? 88  VAL A HG12 1 
ATOM   1338 H HG13 . VAL A 1 91  ? 29.16568 -13.46064 10.14705 1.000 12.19030  ? 88  VAL A HG13 1 
ATOM   1339 H HG21 . VAL A 1 91  ? 27.34550 -14.08415 12.55633 1.000 21.02955  ? 88  VAL A HG21 1 
ATOM   1340 H HG22 . VAL A 1 91  ? 27.04115 -12.96917 11.46652 1.000 21.02955  ? 88  VAL A HG22 1 
ATOM   1341 H HG23 . VAL A 1 91  ? 26.01195 -14.15724 11.69621 1.000 21.02955  ? 88  VAL A HG23 1 
ATOM   1342 N N    . LYS A 1 92  ? 27.50494 -16.44945 7.89280  1.000 13.39086  ? 89  LYS A N    1 
ATOM   1343 C CA   . LYS A 1 92  ? 28.21986 -17.19672 6.85999  1.000 18.14337  ? 89  LYS A CA   1 
ATOM   1344 C C    . LYS A 1 92  ? 28.01825 -16.51411 5.52153  1.000 15.21563  ? 89  LYS A C    1 
ATOM   1345 O O    . LYS A 1 92  ? 28.96753 -16.27931 4.76334  1.000 12.35147  ? 89  LYS A O    1 
ATOM   1346 C CB   . LYS A 1 92  ? 27.73303 -18.64929 6.80324  1.000 15.30171  ? 89  LYS A CB   1 
ATOM   1347 C CG   . LYS A 1 92  ? 28.45880 -19.50243 5.74529  1.000 23.96105  ? 89  LYS A CG   1 
ATOM   1348 C CD   . LYS A 1 92  ? 27.92432 -20.96946 5.68673  1.000 37.80056  ? 89  LYS A CD   1 
ATOM   1349 C CE   . LYS A 1 92  ? 27.70121 -21.63959 7.10509  1.000 36.46888  ? 89  LYS A CE   1 
ATOM   1350 N NZ   . LYS A 1 92  ? 28.91034 -22.03768 8.01052  1.000 28.44009  ? 89  LYS A NZ   1 
ATOM   1351 H H    . LYS A 1 92  ? 26.91661 -16.90564 8.32333  1.000 16.06905  ? 89  LYS A H    1 
ATOM   1352 H HA   . LYS A 1 92  ? 29.16538 -17.22466 7.07475  1.000 21.77206  ? 89  LYS A HA   1 
ATOM   1353 H HB2  . LYS A 1 92  ? 27.87965 -19.06191 7.66877  1.000 18.36207  ? 89  LYS A HB2  1 
ATOM   1354 H HB3  . LYS A 1 92  ? 26.78683 -18.65349 6.58972  1.000 18.36207  ? 89  LYS A HB3  1 
ATOM   1355 H HG2  . LYS A 1 92  ? 28.33021 -19.10104 4.87165  1.000 28.75328  ? 89  LYS A HG2  1 
ATOM   1356 H HG3  . LYS A 1 92  ? 29.40435 -19.53580 5.95913  1.000 28.75328  ? 89  LYS A HG3  1 
ATOM   1357 H HD2  . LYS A 1 92  ? 27.07144 -20.97099 5.22467  1.000 45.36068  ? 89  LYS A HD2  1 
ATOM   1358 H HD3  . LYS A 1 92  ? 28.56472 -21.51418 5.20293  1.000 45.36068  ? 89  LYS A HD3  1 
ATOM   1359 H HE2  . LYS A 1 92  ? 27.17159 -21.02011 7.63108  1.000 43.76267  ? 89  LYS A HE2  1 
ATOM   1360 H HE3  . LYS A 1 92  ? 27.20319 -22.45860 6.95641  1.000 43.76267  ? 89  LYS A HE3  1 
ATOM   1361 H HZ1  . LYS A 1 92  ? 29.11291 -22.89562 7.88797  1.000 34.12813  ? 89  LYS A HZ1  1 
ATOM   1362 H HZ2  . LYS A 1 92  ? 28.70479 -21.90890 8.86682  1.000 34.12813  ? 89  LYS A HZ2  1 
ATOM   1363 H HZ3  . LYS A 1 92  ? 29.62016 -21.54125 7.80605  1.000 34.12813  ? 89  LYS A HZ3  1 
ATOM   1364 N N    . GLU A 1 93  ? 26.78841 -16.10751 5.26902  1.000 11.56498  ? 90  GLU A N    1 
ATOM   1365 C CA   . GLU A 1 93  ? 26.47761 -15.50056 3.99033  1.000 20.92168  ? 90  GLU A CA   1 
ATOM   1366 C C    . GLU A 1 93  ? 27.17335 -14.16405 3.85630  1.000 18.43405  ? 90  GLU A C    1 
ATOM   1367 O O    . GLU A 1 93  ? 27.74479 -13.84984 2.80404  1.000 11.90366  ? 90  GLU A O    1 
ATOM   1368 C CB   . GLU A 1 93  ? 24.96007 -15.36871 3.87855  1.000 21.84838  ? 90  GLU A CB   1 
ATOM   1369 C CG   . GLU A 1 93  ? 24.41767 -14.74840 2.58997  1.000 66.46175  ? 90  GLU A CG   1 
ATOM   1370 C CD   . GLU A 1 93  ? 22.86366 -14.58763 2.59544  1.000 76.62029  ? 90  GLU A CD   1 
ATOM   1371 O OE1  . GLU A 1 93  ? 22.21282 -15.16722 3.50334  1.000 64.99146  ? 90  GLU A OE1  1 
ATOM   1372 O OE2  . GLU A 1 93  ? 22.30349 -13.89041 1.69604  1.000 82.29630  ? 90  GLU A OE2  1 
ATOM   1373 H H    . GLU A 1 93  ? 26.12455 -16.16999 5.81214  1.000 13.87799  ? 90  GLU A H    1 
ATOM   1374 H HA   . GLU A 1 93  ? 26.78606 -16.05604 3.25739  1.000 25.10604  ? 90  GLU A HA   1 
ATOM   1375 H HB2  . GLU A 1 93  ? 24.57537 -16.25631 3.94978  1.000 26.21807  ? 90  GLU A HB2  1 
ATOM   1376 H HB3  . GLU A 1 93  ? 24.65193 -14.81374 4.61200  1.000 26.21807  ? 90  GLU A HB3  1 
ATOM   1377 H HG2  . GLU A 1 93  ? 24.80863 -13.86811 2.47530  1.000 79.75411  ? 90  GLU A HG2  1 
ATOM   1378 H HG3  . GLU A 1 93  ? 24.65645 -15.31750 1.84163  1.000 79.75411  ? 90  GLU A HG3  1 
ATOM   1379 N N    . ILE A 1 94  ? 27.17222 -13.37445 4.93065  1.000 16.86378  ? 91  ILE A N    1 
ATOM   1380 C CA   . ILE A 1 94  ? 27.84167 -12.07965 4.89291  1.000 12.97328  ? 91  ILE A CA   1 
ATOM   1381 C C    . ILE A 1 94  ? 29.33119 -12.24454 4.65324  1.000 15.51457  ? 91  ILE A C    1 
ATOM   1382 O O    . ILE A 1 94  ? 29.94472 -11.48944 3.88524  1.000 11.91412  ? 91  ILE A O    1 
ATOM   1383 C CB   . ILE A 1 94  ? 27.58641 -11.31033 6.20371  1.000 22.84966  ? 91  ILE A CB   1 
ATOM   1384 C CG1  . ILE A 1 94  ? 26.15181 -10.78573 6.27270  1.000 29.30132  ? 91  ILE A CG1  1 
ATOM   1385 C CG2  . ILE A 1 94  ? 28.53323 -10.14852 6.30007  1.000 26.11151  ? 91  ILE A CG2  1 
ATOM   1386 C CD1  . ILE A 1 94  ? 25.68982 -10.28599 7.68421  1.000 42.50251  ? 91  ILE A CD1  1 
ATOM   1387 H H    . ILE A 1 94  ? 26.79668 -13.56345 5.68088  1.000 20.23655  ? 91  ILE A H    1 
ATOM   1388 H HA   . ILE A 1 94  ? 27.47157 -11.57447 4.15215  1.000 15.56795  ? 91  ILE A HA   1 
ATOM   1389 H HB   . ILE A 1 94  ? 27.72750 -11.92689 6.93913  1.000 27.41961  ? 91  ILE A HB   1 
ATOM   1390 H HG12 . ILE A 1 94  ? 26.06934 -10.03857 5.65964  1.000 35.16160  ? 91  ILE A HG12 1 
ATOM   1391 H HG13 . ILE A 1 94  ? 25.55160 -11.50016 6.00765  1.000 35.16160  ? 91  ILE A HG13 1 
ATOM   1392 H HG21 . ILE A 1 94  ? 28.18414 -9.50891  6.94033  1.000 31.33383  ? 91  ILE A HG21 1 
ATOM   1393 H HG22 . ILE A 1 94  ? 29.39981 -10.47084 6.59341  1.000 31.33383  ? 91  ILE A HG22 1 
ATOM   1394 H HG23 . ILE A 1 94  ? 28.61300 -9.73291  5.42725  1.000 31.33383  ? 91  ILE A HG23 1 
ATOM   1395 H HD11 . ILE A 1 94  ? 24.72489 -10.18690 7.68389  1.000 51.00303  ? 91  ILE A HD11 1 
ATOM   1396 H HD12 . ILE A 1 94  ? 25.95523 -10.93727 8.35226  1.000 51.00303  ? 91  ILE A HD12 1 
ATOM   1397 H HD13 . ILE A 1 94  ? 26.11001 -9.43166  7.86986  1.000 51.00303  ? 91  ILE A HD13 1 
ATOM   1398 N N    . LEU A 1 95  ? 29.95876 -13.16700 5.37412  1.000 10.61213  ? 92  LEU A N    1 
ATOM   1399 C CA   . LEU A 1 95  ? 31.40106 -13.33293 5.20134  1.000 5.72041   ? 92  LEU A CA   1 
ATOM   1400 C C    . LEU A 1 95  ? 31.74251 -13.87214 3.81877  1.000 17.74468  ? 92  LEU A C    1 
ATOM   1401 O O    . LEU A 1 95  ? 32.68681 -13.37176 3.17657  1.000 12.77148  ? 92  LEU A O    1 
ATOM   1402 C CB   . LEU A 1 95  ? 31.93938 -14.22512 6.32531  1.000 16.01533  ? 92  LEU A CB   1 
ATOM   1403 C CG   . LEU A 1 95  ? 31.76288 -13.70501 7.77535  1.000 13.54428  ? 92  LEU A CG   1 
ATOM   1404 C CD1  . LEU A 1 95  ? 32.10005 -14.73270 8.89582  1.000 11.65211  ? 92  LEU A CD1  1 
ATOM   1405 C CD2  . LEU A 1 95  ? 32.56838 -12.41170 7.96692  1.000 17.01373  ? 92  LEU A CD2  1 
ATOM   1406 H H    A LEU A 1 95  ? 29.59007 -13.69056 5.94818  0.650 12.73457  ? 92  LEU A H    1 
ATOM   1407 H H    B LEU A 1 95  ? 29.59007 -13.69056 5.94818  0.350 12.73457  ? 92  LEU A H    1 
ATOM   1408 H HA   . LEU A 1 95  ? 31.84336 -12.47252 5.27189  1.000 6.86450   ? 92  LEU A HA   1 
ATOM   1409 H HB2  . LEU A 1 95  ? 31.48400 -15.07999 6.27300  1.000 19.21841  ? 92  LEU A HB2  1 
ATOM   1410 H HB3  . LEU A 1 95  ? 32.89088 -14.34673 6.18123  1.000 19.21841  ? 92  LEU A HB3  1 
ATOM   1411 H HG   . LEU A 1 95  ? 30.81500 -13.53165 7.88658  1.000 16.25315  ? 92  LEU A HG   1 
ATOM   1412 H HD11 . LEU A 1 95  ? 31.92416 -14.32744 9.75937  1.000 13.98255  ? 92  LEU A HD11 1 
ATOM   1413 H HD12 . LEU A 1 95  ? 31.54451 -15.51943 8.78033  1.000 13.98255  ? 92  LEU A HD12 1 
ATOM   1414 H HD13 . LEU A 1 95  ? 33.03657 -14.97642 8.82939  1.000 13.98255  ? 92  LEU A HD13 1 
ATOM   1415 H HD21 . LEU A 1 95  ? 32.55752 -12.16907 8.90603  1.000 20.41649  ? 92  LEU A HD21 1 
ATOM   1416 H HD22 . LEU A 1 95  ? 33.48102 -12.56183 7.67461  1.000 20.41649  ? 92  LEU A HD22 1 
ATOM   1417 H HD23 . LEU A 1 95  ? 32.16355 -11.70629 7.43833  1.000 20.41649  ? 92  LEU A HD23 1 
ATOM   1418 N N    A LYS A 1 96  ? 30.99755 -14.87963 3.33084  0.559 16.04871  ? 93  LYS A N    1 
ATOM   1419 N N    B LYS A 1 96  ? 31.01391 -14.89112 3.33512  0.441 16.05462  ? 93  LYS A N    1 
ATOM   1420 C CA   A LYS A 1 96  ? 31.31556 -15.44001 2.00168  0.559 14.00779  ? 93  LYS A CA   1 
ATOM   1421 C CA   B LYS A 1 96  ? 31.33660 -15.43321 2.00282  0.441 14.01503  ? 93  LYS A CA   1 
ATOM   1422 C C    A LYS A 1 96  ? 31.20334 -14.36397 0.93341  0.559 16.42537  ? 93  LYS A C    1 
ATOM   1423 C C    B LYS A 1 96  ? 31.22572 -14.34433 0.94739  0.441 16.44223  ? 93  LYS A C    1 
ATOM   1424 O O    A LYS A 1 96  ? 32.05225 -14.26849 0.03911  0.559 17.09220  ? 93  LYS A O    1 
ATOM   1425 O O    B LYS A 1 96  ? 32.08637 -14.23077 0.06614  0.441 17.10504  ? 93  LYS A O    1 
ATOM   1426 C CB   A LYS A 1 96  ? 30.40050 -16.64031 1.68598  0.559 14.40110  ? 93  LYS A CB   1 
ATOM   1427 C CB   B LYS A 1 96  ? 30.42815 -16.62561 1.65706  0.441 14.40015  ? 93  LYS A CB   1 
ATOM   1428 C CG   A LYS A 1 96  ? 30.68375 -17.87377 2.59405  0.559 27.89079  ? 93  LYS A CG   1 
ATOM   1429 C CG   B LYS A 1 96  ? 30.94925 -18.00376 2.17464  0.441 26.90367  ? 93  LYS A CG   1 
ATOM   1430 C CD   A LYS A 1 96  ? 30.04410 -19.18298 2.11597  0.559 27.52520  ? 93  LYS A CD   1 
ATOM   1431 C CD   B LYS A 1 96  ? 32.26919 -18.44636 1.48311  0.441 24.20207  ? 93  LYS A CD   1 
ATOM   1432 C CE   A LYS A 1 96  ? 30.48927 -20.42419 2.96272  0.559 30.12743  ? 93  LYS A CE   1 
ATOM   1433 C CE   B LYS A 1 96  ? 32.87079 -19.77505 2.02083  0.441 22.52882  ? 93  LYS A CE   1 
ATOM   1434 N NZ   A LYS A 1 96  ? 31.91455 -20.91871 2.72071  0.559 28.75301  ? 93  LYS A NZ   1 
ATOM   1435 N NZ   B LYS A 1 96  ? 34.31493 -19.96482 1.62058  0.441 15.30224  ? 93  LYS A NZ   1 
ATOM   1436 H H    A LYS A 1 96  ? 30.32917 -15.24343 3.73148  0.559 19.25847  ? 93  LYS A H    1 
ATOM   1437 H H    B LYS A 1 96  ? 30.35644 -15.27077 3.73910  0.441 19.26556  ? 93  LYS A H    1 
ATOM   1438 H HA   A LYS A 1 96  ? 32.22631 -15.77382 2.00400  0.559 16.80936  ? 93  LYS A HA   1 
ATOM   1439 H HA   B LYS A 1 96  ? 32.24729 -15.76705 2.01274  0.441 16.81806  ? 93  LYS A HA   1 
ATOM   1440 H HB2  A LYS A 1 96  ? 29.47677 -16.37590 1.81905  0.559 17.28134  ? 93  LYS A HB2  1 
ATOM   1441 H HB2  B LYS A 1 96  ? 29.55534 -16.47452 2.05238  0.441 17.28019  ? 93  LYS A HB2  1 
ATOM   1442 H HB3  A LYS A 1 96  ? 30.53932 -16.90849 0.76418  0.559 17.28134  ? 93  LYS A HB3  1 
ATOM   1443 H HB3  B LYS A 1 96  ? 30.34949 -16.68511 0.69209  0.441 17.28019  ? 93  LYS A HB3  1 
ATOM   1444 H HG2  A LYS A 1 96  ? 31.64259 -18.01535 2.63248  0.559 33.46897  ? 93  LYS A HG2  1 
ATOM   1445 H HG2  B LYS A 1 96  ? 31.11716 -17.94080 3.12792  0.441 32.28441  ? 93  LYS A HG2  1 
ATOM   1446 H HG3  A LYS A 1 96  ? 30.33981 -17.68908 3.48203  0.559 33.46897  ? 93  LYS A HG3  1 
ATOM   1447 H HG3  B LYS A 1 96  ? 30.27783 -18.68172 2.00010  0.441 32.28441  ? 93  LYS A HG3  1 
ATOM   1448 H HD2  A LYS A 1 96  ? 29.07946 -19.10610 2.18267  0.559 33.03025  ? 93  LYS A HD2  1 
ATOM   1449 H HD2  B LYS A 1 96  ? 32.09650 -18.56712 0.53627  0.441 29.04250  ? 93  LYS A HD2  1 
ATOM   1450 H HD3  A LYS A 1 96  ? 30.30129 -19.34213 1.19432  0.559 33.03025  ? 93  LYS A HD3  1 
ATOM   1451 H HD3  B LYS A 1 96  ? 32.93400 -17.75209 1.61318  0.441 29.04250  ? 93  LYS A HD3  1 
ATOM   1452 H HE2  A LYS A 1 96  ? 30.42228 -20.19174 3.90207  0.559 36.15293  ? 93  LYS A HE2  1 
ATOM   1453 H HE2  B LYS A 1 96  ? 32.82572 -19.77370 2.98978  0.441 27.03460  ? 93  LYS A HE2  1 
ATOM   1454 H HE3  A LYS A 1 96  ? 29.89201 -21.16111 2.75991  0.559 36.15293  ? 93  LYS A HE3  1 
ATOM   1455 H HE3  B LYS A 1 96  ? 32.36076 -20.51995 1.66602  0.441 27.03460  ? 93  LYS A HE3  1 
ATOM   1456 H HZ1  A LYS A 1 96  ? 32.49717 -20.27381 2.91243  0.559 34.50362  ? 93  LYS A HZ1  1 
ATOM   1457 H HZ1  B LYS A 1 96  ? 34.38471 -19.98589 0.73357  0.441 18.36270  ? 93  LYS A HZ1  1 
ATOM   1458 H HZ2  A LYS A 1 96  ? 32.01444 -21.15413 1.86824  0.559 34.50362  ? 93  LYS A HZ2  1 
ATOM   1459 H HZ2  B LYS A 1 96  ? 34.80823 -19.29326 1.93324  0.441 18.36270  ? 93  LYS A HZ2  1 
ATOM   1460 H HZ3  A LYS A 1 96  ? 32.08389 -21.62374 3.23681  0.559 34.50362  ? 93  LYS A HZ3  1 
ATOM   1461 H HZ3  B LYS A 1 96  ? 34.62489 -20.73003 1.95295  0.441 18.36270  ? 93  LYS A HZ3  1 
ATOM   1462 N N    . GLU A 1 97  ? 30.20323 -13.50060 1.05000  1.000 14.14477  ? 94  GLU A N    1 
ATOM   1463 C CA   . GLU A 1 97  ? 30.06217 -12.42894 0.08166  1.000 20.77069  ? 94  GLU A CA   1 
ATOM   1464 C C    . GLU A 1 97  ? 31.19905 -11.43368 0.20605  1.000 31.01873  ? 94  GLU A C    1 
ATOM   1465 O O    . GLU A 1 97  ? 31.70382 -10.93181 -0.81479 1.000 13.46444  ? 94  GLU A O    1 
ATOM   1466 C CB   . GLU A 1 97  ? 28.71363 -11.75632 0.25383  1.000 17.22119  ? 94  GLU A CB   1 
ATOM   1467 C CG   . GLU A 1 97  ? 28.61491 -10.43394 -0.45446 1.000 35.29762  ? 94  GLU A CG   1 
ATOM   1468 C CD   . GLU A 1 97  ? 27.24107 -9.76759  -0.26084 1.000 76.65531  ? 94  GLU A CD   1 
ATOM   1469 O OE1  . GLU A 1 97  ? 26.35811 -10.34597 0.42210  1.000 73.35771  ? 94  GLU A OE1  1 
ATOM   1470 O OE2  . GLU A 1 97  ? 27.03926 -8.65691  -0.80050 1.000 80.90513  ? 94  GLU A OE2  1 
ATOM   1471 H H    A GLU A 1 97  ? 29.60565 -13.51393 1.66832  0.559 16.97374  ? 94  GLU A H    1 
ATOM   1472 H H    B GLU A 1 97  ? 29.59429 -13.52851 1.65663  0.441 16.97374  ? 94  GLU A H    1 
ATOM   1473 H HA   . GLU A 1 97  ? 30.09262 -12.79622 -0.81560 1.000 24.92484  ? 94  GLU A HA   1 
ATOM   1474 H HB2  . GLU A 1 97  ? 28.02488 -12.33830 -0.10370 1.000 20.66545  ? 94  GLU A HB2  1 
ATOM   1475 H HB3  . GLU A 1 97  ? 28.55898 -11.60083 1.19871  1.000 20.66545  ? 94  GLU A HB3  1 
ATOM   1476 H HG2  . GLU A 1 97  ? 29.29280 -9.83479  -0.10463 1.000 42.35716  ? 94  GLU A HG2  1 
ATOM   1477 H HG3  . GLU A 1 97  ? 28.75223 -10.57153 -1.40479 1.000 42.35716  ? 94  GLU A HG3  1 
ATOM   1478 N N    . GLN A 1 98  ? 31.62508 -11.14219 1.43859  1.000 14.98232  ? 95  GLN A N    1 
ATOM   1479 C CA   . GLN A 1 98  ? 32.71535 -10.20631 1.63357  1.000 14.24499  ? 95  GLN A CA   1 
ATOM   1480 C C    . GLN A 1 98  ? 34.02121 -10.75993 1.07460  1.000 11.90296  ? 95  GLN A C    1 
ATOM   1481 O O    . GLN A 1 98  ? 34.81343 -10.03685 0.44016  1.000 13.27317  ? 95  GLN A O    1 
ATOM   1482 C CB   . GLN A 1 98  ? 32.82841 -9.90678  3.13474  1.000 22.82275  ? 95  GLN A CB   1 
ATOM   1483 C CG   . GLN A 1 98  ? 33.88010 -8.86937  3.42186  1.000 12.26227  ? 95  GLN A CG   1 
ATOM   1484 C CD   . GLN A 1 98  ? 33.38040 -7.44162  3.06681  1.000 22.06924  ? 95  GLN A CD   1 
ATOM   1485 O OE1  . GLN A 1 98  ? 32.34162 -7.27802  2.42008  1.000 18.82213  ? 95  GLN A OE1  1 
ATOM   1486 N NE2  . GLN A 1 98  ? 34.10187 -6.42659  3.50880  1.000 12.59128  ? 95  GLN A NE2  1 
ATOM   1487 H H    . GLN A 1 98  ? 31.30011 -11.47140 2.16359  1.000 17.97880  ? 95  GLN A H    1 
ATOM   1488 H HA   . GLN A 1 98  ? 32.53751 -9.37642  1.16394  1.000 17.09400  ? 95  GLN A HA   1 
ATOM   1489 H HB2  . GLN A 1 98  ? 31.97675 -9.57422  3.45875  1.000 27.38731  ? 95  GLN A HB2  1 
ATOM   1490 H HB3  . GLN A 1 98  ? 33.06752 -10.72058 3.60533  1.000 27.38731  ? 95  GLN A HB3  1 
ATOM   1491 H HG2  . GLN A 1 98  ? 34.10194 -8.88955  4.36594  1.000 14.71474  ? 95  GLN A HG2  1 
ATOM   1492 H HG3  . GLN A 1 98  ? 34.67009 -9.05740  2.89134  1.000 14.71474  ? 95  GLN A HG3  1 
ATOM   1493 H HE21 . GLN A 1 98  ? 34.81252 -6.57295  3.97048  1.000 15.10955  ? 95  GLN A HE21 1 
ATOM   1494 H HE22 . GLN A 1 98  ? 33.86075 -5.61964  3.33477  1.000 15.10955  ? 95  GLN A HE22 1 
ATOM   1495 N N    . GLU A 1 99  ? 34.26893 -12.03241 1.31715  1.000 8.78879   ? 96  GLU A N    1 
ATOM   1496 C CA   . GLU A 1 99  ? 35.42036 -12.66682 0.70784  1.000 12.94653  ? 96  GLU A CA   1 
ATOM   1497 C C    . GLU A 1 99  ? 35.34657 -12.54593 -0.83086 1.000 25.43812  ? 96  GLU A C    1 
ATOM   1498 O O    . GLU A 1 99  ? 36.31956 -12.13302 -1.45225 1.000 14.08063  ? 96  GLU A O    1 
ATOM   1499 C CB   . GLU A 1 99  ? 35.50979 -14.11116 1.23579  1.000 17.68583  ? 96  GLU A CB   1 
ATOM   1500 C CG   . GLU A 1 99  ? 36.87123 -14.81971 0.99875  1.000 19.21549  ? 96  GLU A CG   1 
ATOM   1501 C CD   . GLU A 1 99  ? 36.95265 -16.28854 1.48284  1.000 19.33331  ? 96  GLU A CD   1 
ATOM   1502 O OE1  . GLU A 1 99  ? 35.94556 -17.03577 1.49150  1.000 29.49053  ? 96  GLU A OE1  1 
ATOM   1503 O OE2  . GLU A 1 99  ? 38.06938 -16.70376 1.85990  1.000 30.67683  ? 96  GLU A OE2  1 
ATOM   1504 H H    . GLU A 1 99  ? 33.79533 -12.54314 1.82158  1.000 10.54657  ? 96  GLU A H    1 
ATOM   1505 H HA   . GLU A 1 99  ? 36.25287 -12.23620 0.95763  1.000 15.53586  ? 96  GLU A HA   1 
ATOM   1506 H HB2  . GLU A 1 99  ? 35.35304 -14.09738 2.19294  1.000 21.22301  ? 96  GLU A HB2  1 
ATOM   1507 H HB3  . GLU A 1 99  ? 34.82688 -14.64082 0.79536  1.000 21.22301  ? 96  GLU A HB3  1 
ATOM   1508 H HG2  . GLU A 1 99  ? 37.05355 -14.81990 0.04604  1.000 23.05860  ? 96  GLU A HG2  1 
ATOM   1509 H HG3  . GLU A 1 99  ? 37.55969 -14.32315 1.46818  1.000 23.05860  ? 96  GLU A HG3  1 
ATOM   1510 N N    . ASN A 1 100 ? 34.17192 -12.76412 -1.44738 1.000 17.83996  ? 97  ASN A N    1 
ATOM   1511 C CA   . ASN A 1 100 ? 34.15759 -12.85321 -2.91177 1.000 26.90693  ? 97  ASN A CA   1 
ATOM   1512 C C    . ASN A 1 100 ? 34.41829 -11.52234 -3.57771 1.000 24.89169  ? 97  ASN A C    1 
ATOM   1513 O O    . ASN A 1 100 ? 34.96726 -11.46411 -4.68613 1.000 25.70003  ? 97  ASN A O    1 
ATOM   1514 C CB   . ASN A 1 100 ? 32.82404 -13.37631 -3.38851 1.000 25.12718  ? 97  ASN A CB   1 
ATOM   1515 C CG   . ASN A 1 100 ? 32.65120 -14.82965 -3.05490 1.000 67.24425  ? 97  ASN A CG   1 
ATOM   1516 O OD1  . ASN A 1 100 ? 33.63964 -15.57190 -2.91856 1.000 54.73774  ? 97  ASN A OD1  1 
ATOM   1517 N ND2  . ASN A 1 100 ? 31.39415 -15.25339 -2.86993 1.000 54.50572  ? 97  ASN A ND2  1 
ATOM   1518 H H    . ASN A 1 100 ? 33.41055 -12.85880 -1.05886 1.000 21.40797  ? 97  ASN A H    1 
ATOM   1519 H HA   . ASN A 1 100 ? 34.86293 -13.46845 -3.16646 1.000 32.28834  ? 97  ASN A HA   1 
ATOM   1520 H HB2  . ASN A 1 100 ? 32.11161 -12.87775 -2.95864 1.000 30.15264  ? 97  ASN A HB2  1 
ATOM   1521 H HB3  . ASN A 1 100 ? 32.76545 -13.27523 -4.35145 1.000 30.15264  ? 97  ASN A HB3  1 
ATOM   1522 H HD21 . ASN A 1 100 ? 31.24221 -16.07754 -2.67683 1.000 65.40688  ? 97  ASN A HD21 1 
ATOM   1523 H HD22 . ASN A 1 100 ? 30.73895 -14.70131 -2.94428 1.000 65.40688  ? 97  ASN A HD22 1 
ATOM   1524 N N    . ARG A 1 101 ? 33.95537 -10.45924 -2.96081 1.000 15.03023  ? 98  ARG A N    1 
ATOM   1525 C CA   . ARG A 1 101 ? 34.19233 -9.14513  -3.48352 1.000 21.04622  ? 98  ARG A CA   1 
ATOM   1526 C C    . ARG A 1 101 ? 35.46503 -8.54993  -2.94172 1.000 21.73770  ? 98  ARG A C    1 
ATOM   1527 O O    . ARG A 1 101 ? 35.68437 -7.34589  -3.10942 1.000 27.91321  ? 98  ARG A O    1 
ATOM   1528 C CB   . ARG A 1 101 ? 33.01347 -8.23664  -3.17475 1.000 28.67079  ? 98  ARG A CB   1 
ATOM   1529 C CG   . ARG A 1 101 ? 32.77754 -7.98635  -1.71565 1.000 52.89788  ? 98  ARG A CG   1 
ATOM   1530 C CD   . ARG A 1 101 ? 31.62959 -6.97081  -1.52564 1.000 43.18109  ? 98  ARG A CD   1 
ATOM   1531 N NE   . ARG A 1 101 ? 31.98082 -5.62478  -1.97569 1.000 51.00936  ? 98  ARG A NE   1 
ATOM   1532 C CZ   . ARG A 1 101 ? 32.64211 -4.71808  -1.25557 1.000 69.72602  ? 98  ARG A CZ   1 
ATOM   1533 N NH1  . ARG A 1 101 ? 33.05153 -4.97050  -0.01861 1.000 36.74472  ? 98  ARG A NH1  1 
ATOM   1534 N NH2  . ARG A 1 101 ? 32.88826 -3.52123  -1.78973 1.000 65.81145  ? 98  ARG A NH2  1 
ATOM   1535 H H    A ARG A 1 101 ? 33.49824 -10.47812 -2.23261 0.410 18.03629  ? 98  ARG A H    1 
ATOM   1536 H H    B ARG A 1 101 ? 33.49824 -10.47812 -2.23261 0.590 18.03629  ? 98  ARG A H    1 
ATOM   1537 H HA   . ARG A 1 101 ? 34.26894 -9.19530  -4.44919 1.000 25.25548  ? 98  ARG A HA   1 
ATOM   1538 H HB2  . ARG A 1 101 ? 33.16856 -7.37712  -3.59676 1.000 34.40496  ? 98  ARG A HB2  1 
ATOM   1539 H HB3  . ARG A 1 101 ? 32.20947 -8.64271  -3.53474 1.000 34.40496  ? 98  ARG A HB3  1 
ATOM   1540 H HG2  . ARG A 1 101 ? 32.53257 -8.81660  -1.27795 1.000 63.47747  ? 98  ARG A HG2  1 
ATOM   1541 H HG3  . ARG A 1 101 ? 33.58203 -7.62377  -1.31287 1.000 63.47747  ? 98  ARG A HG3  1 
ATOM   1542 H HD2  . ARG A 1 101 ? 30.85943 -7.26560  -2.03638 1.000 51.81732  ? 98  ARG A HD2  1 
ATOM   1543 H HD3  . ARG A 1 101 ? 31.40395 -6.92192  -0.58352 1.000 51.81732  ? 98  ARG A HD3  1 
ATOM   1544 H HE   . ARG A 1 101 ? 31.74119 -5.39928  -2.77025 1.000 61.21125  ? 98  ARG A HE   1 
ATOM   1545 H HH11 . ARG A 1 101 ? 32.89204 -5.73603  0.33933  1.000 44.09368  ? 98  ARG A HH11 1 
ATOM   1546 H HH12 . ARG A 1 101 ? 33.47633 -4.36853  0.42500  1.000 44.09368  ? 98  ARG A HH12 1 
ATOM   1547 H HH21 . ARG A 1 101 ? 32.62148 -3.34340  -2.58773 1.000 78.97376  ? 98  ARG A HH21 1 
ATOM   1548 H HH22 . ARG A 1 101 ? 33.31379 -2.92723  -1.33621 1.000 78.97376  ? 98  ARG A HH22 1 
ATOM   1549 N N    . LYS A 1 102 ? 36.30187 -9.34732  -2.28325 1.000 25.02209  ? 99  LYS A N    1 
ATOM   1550 C CA   . LYS A 1 102 ? 37.61400 -8.85500  -1.82965 1.000 25.41975  ? 99  LYS A CA   1 
ATOM   1551 C C    . LYS A 1 102 ? 37.49362 -7.66409  -0.89528 1.000 24.24148  ? 99  LYS A C    1 
ATOM   1552 O O    . LYS A 1 102 ? 38.31011 -6.74613  -0.91172 1.000 22.52353  ? 99  LYS A O    1 
ATOM   1553 C CB   . LYS A 1 102 ? 38.48273 -8.52005  -3.04233 1.000 32.33987  ? 99  LYS A CB   1 
ATOM   1554 C CG   . LYS A 1 102 ? 38.75794 -9.80447  -3.88930 1.000 40.04940  ? 99  LYS A CG   1 
ATOM   1555 C CD   . LYS A 1 102 ? 39.32373 -9.52023  -5.28474 1.000 60.38130  ? 99  LYS A CD   1 
ATOM   1556 C CE   . LYS A 1 102 ? 40.86692 -9.35565  -5.28488 1.000 72.48656  ? 99  LYS A CE   1 
ATOM   1557 N NZ   . LYS A 1 102 ? 41.39988 -8.76092  -6.57320 1.000 74.24301  ? 99  LYS A NZ   1 
ATOM   1558 H H    . LYS A 1 102 ? 36.14044 -10.16875 -2.08633 1.000 30.02653  ? 99  LYS A H    1 
ATOM   1559 H HA   . LYS A 1 102 ? 38.04557 -9.55260  -1.31196 1.000 30.50371  ? 99  LYS A HA   1 
ATOM   1560 H HB2  . LYS A 1 102 ? 38.02445 -7.87278  -3.60083 1.000 38.80787  ? 99  LYS A HB2  1 
ATOM   1561 H HB3  . LYS A 1 102 ? 39.33157 -8.15819  -2.74327 1.000 38.80787  ? 99  LYS A HB3  1 
ATOM   1562 H HG2  . LYS A 1 102 ? 39.40084 -10.35707 -3.41791 1.000 48.05929  ? 99  LYS A HG2  1 
ATOM   1563 H HG3  . LYS A 1 102 ? 37.92468 -10.28798 -4.00236 1.000 48.05929  ? 99  LYS A HG3  1 
ATOM   1564 H HD2  . LYS A 1 102 ? 39.10124 -10.25876 -5.87292 1.000 72.45758  ? 99  LYS A HD2  1 
ATOM   1565 H HD3  . LYS A 1 102 ? 38.93484 -8.69831  -5.62253 1.000 72.45758  ? 99  LYS A HD3  1 
ATOM   1566 H HE2  . LYS A 1 102 ? 41.12127 -8.76730  -4.55683 1.000 86.98389  ? 99  LYS A HE2  1 
ATOM   1567 H HE3  . LYS A 1 102 ? 41.27685 -10.22672 -5.16619 1.000 86.98389  ? 99  LYS A HE3  1 
ATOM   1568 H HZ1  . LYS A 1 102 ? 42.28761 -8.70721  -6.53930 1.000 89.09163  ? 99  LYS A HZ1  1 
ATOM   1569 H HZ2  . LYS A 1 102 ? 41.16761 -9.27238  -7.26353 1.000 89.09163  ? 99  LYS A HZ2  1 
ATOM   1570 H HZ3  . LYS A 1 102 ? 41.06551 -7.94486  -6.69294 1.000 89.09163  ? 99  LYS A HZ3  1 
ATOM   1571 N N    . GLY A 1 103 ? 36.52031 -7.70906  -0.04022 1.000 15.41809  ? 100 GLY A N    1 
ATOM   1572 C CA   . GLY A 1 103 ? 36.49507 -6.76807  1.04898  1.000 16.05094  ? 100 GLY A CA   1 
ATOM   1573 C C    . GLY A 1 103 ? 37.23107 -7.30245  2.27618  1.000 14.35301  ? 100 GLY A C    1 
ATOM   1574 O O    . GLY A 1 103 ? 37.45451 -8.48555  2.47494  1.000 12.87286  ? 100 GLY A O    1 
ATOM   1575 H H    . GLY A 1 103 ? 35.86539 -8.26605  -0.06140 1.000 18.50172  ? 100 GLY A H    1 
ATOM   1576 H HA2  . GLY A 1 103 ? 36.91846 -5.94068  0.77135  1.000 19.26115  ? 100 GLY A HA2  1 
ATOM   1577 H HA3  . GLY A 1 103 ? 35.57531 -6.58458  1.29651  1.000 19.26115  ? 100 GLY A HA3  1 
ATOM   1578 N N    . LEU A 1 104 ? 37.60652 -6.35370  3.11676  1.000 8.99282   ? 101 LEU A N    1 
ATOM   1579 C CA   . LEU A 1 104 ? 38.26933 -6.65954  4.37488  1.000 9.68688   ? 101 LEU A CA   1 
ATOM   1580 C C    . LEU A 1 104 ? 37.36075 -7.30389  5.40935  1.000 11.80085  ? 101 LEU A C    1 
ATOM   1581 O O    . LEU A 1 104 ? 36.18747 -6.92276  5.57823  1.000 11.42495  ? 101 LEU A O    1 
ATOM   1582 C CB   . LEU A 1 104 ? 38.84217 -5.35422  4.91737  1.000 6.69494   ? 101 LEU A CB   1 
ATOM   1583 C CG   . LEU A 1 104 ? 39.75068 -5.42545  6.12631  1.000 24.77412  ? 101 LEU A CG   1 
ATOM   1584 C CD1  . LEU A 1 104 ? 40.88696 -6.36548  5.69702  1.000 22.66353  ? 101 LEU A CD1  1 
ATOM   1585 C CD2  . LEU A 1 104 ? 40.12137 -3.98813  6.50609  1.000 25.19363  ? 101 LEU A CD2  1 
ATOM   1586 H H    . LEU A 1 104 ? 37.48847 -5.51251  2.98238  1.000 10.79140  ? 101 LEU A H    1 
ATOM   1587 H HA   . LEU A 1 104 ? 38.96803 -7.31329  4.21573  1.000 11.62427  ? 101 LEU A HA   1 
ATOM   1588 H HB2  . LEU A 1 104 ? 39.35620 -4.94018  4.20656  1.000 8.03395   ? 101 LEU A HB2  1 
ATOM   1589 H HB3  . LEU A 1 104 ? 38.09631 -4.78458  5.16253  1.000 8.03395   ? 101 LEU A HB3  1 
ATOM   1590 H HG   . LEU A 1 104 ? 39.38335 -5.79090  6.94632  1.000 29.72896  ? 101 LEU A HG   1 
ATOM   1591 H HD11 . LEU A 1 104 ? 41.68304 -6.15297  6.20888  1.000 27.19625  ? 101 LEU A HD11 1 
ATOM   1592 H HD12 . LEU A 1 104 ? 40.61951 -7.28230  5.86679  1.000 27.19625  ? 101 LEU A HD12 1 
ATOM   1593 H HD13 . LEU A 1 104 ? 41.05924 -6.24103  4.75059  1.000 27.19625  ? 101 LEU A HD13 1 
ATOM   1594 H HD21 . LEU A 1 104 ? 40.70196 -4.00649  7.28292  1.000 30.23237  ? 101 LEU A HD21 1 
ATOM   1595 H HD22 . LEU A 1 104 ? 40.58073 -3.57271  5.75955  1.000 30.23237  ? 101 LEU A HD22 1 
ATOM   1596 H HD23 . LEU A 1 104 ? 39.31062 -3.49644  6.71061  1.000 30.23237  ? 101 LEU A HD23 1 
ATOM   1597 N N    . ILE A 1 105 ? 37.92880 -8.28063  6.11273  1.000 9.96816   ? 102 ILE A N    1 
ATOM   1598 C CA   . ILE A 1 105 ? 37.30459 -9.03475  7.19955  1.000 11.40165  ? 102 ILE A CA   1 
ATOM   1599 C C    . ILE A 1 105 ? 38.23360 -8.89940  8.38137  1.000 11.79892  ? 102 ILE A C    1 
ATOM   1600 O O    . ILE A 1 105 ? 39.44975 -9.10394  8.24732  1.000 8.81263   ? 102 ILE A O    1 
ATOM   1601 C CB   . ILE A 1 105 ? 37.08425 -10.50258 6.83848  1.000 9.69285   ? 102 ILE A CB   1 
ATOM   1602 C CG1  . ILE A 1 105 ? 36.12485 -10.51051 5.65365  1.000 15.41701  ? 102 ILE A CG1  1 
ATOM   1603 C CG2  . ILE A 1 105 ? 36.59533 -11.22045 8.07241  1.000 14.98025  ? 102 ILE A CG2  1 
ATOM   1604 C CD1  . ILE A 1 105 ? 35.79613 -11.94050 5.16577  1.000 18.64665  ? 102 ILE A CD1  1 
ATOM   1605 H H    . ILE A 1 105 ? 38.73462 -8.54428  5.96874  1.000 11.96181  ? 102 ILE A H    1 
ATOM   1606 H HA   . ILE A 1 105 ? 36.43419 -8.66447  7.41445  1.000 13.68199  ? 102 ILE A HA   1 
ATOM   1607 H HB   . ILE A 1 105 ? 37.88583 -10.97479 6.56394  1.000 11.63144  ? 102 ILE A HB   1 
ATOM   1608 H HG12 . ILE A 1 105 ? 35.29434 -10.08356 5.91607  1.000 18.50043  ? 102 ILE A HG12 1 
ATOM   1609 H HG13 . ILE A 1 105 ? 36.52838 -10.02618 4.91644  1.000 18.50043  ? 102 ILE A HG13 1 
ATOM   1610 H HG21 . ILE A 1 105 ? 36.31384 -12.11550 7.82634  1.000 17.97631  ? 102 ILE A HG21 1 
ATOM   1611 H HG22 . ILE A 1 105 ? 37.31783 -11.26668 8.71798  1.000 17.97631  ? 102 ILE A HG22 1 
ATOM   1612 H HG23 . ILE A 1 105 ? 35.84736 -10.72990 8.44763  1.000 17.97631  ? 102 ILE A HG23 1 
ATOM   1613 H HD11 . ILE A 1 105 ? 35.22053 -12.37173 5.81664  1.000 22.37599  ? 102 ILE A HD11 1 
ATOM   1614 H HD12 . ILE A 1 105 ? 35.34412 -11.88585 4.30927  1.000 22.37599  ? 102 ILE A HD12 1 
ATOM   1615 H HD13 . ILE A 1 105 ? 36.62234 -12.44007 5.07248  1.000 22.37599  ? 102 ILE A HD13 1 
ATOM   1616 N N    . ALA A 1 106 ? 37.69678 -8.43401  9.50897  1.000 7.85406   ? 103 ALA A N    1 
ATOM   1617 C CA   . ALA A 1 106 ? 38.54268 -8.15057  10.66825 1.000 5.61553   ? 103 ALA A CA   1 
ATOM   1618 C C    . ALA A 1 106 ? 37.90747 -8.87720  11.83827 1.000 6.07690   ? 103 ALA A C    1 
ATOM   1619 O O    . ALA A 1 106 ? 36.69479 -8.76885  12.04204 1.000 8.26054   ? 103 ALA A O    1 
ATOM   1620 C CB   . ALA A 1 106 ? 38.63348 -6.63179  10.97180 1.000 6.53033   ? 103 ALA A CB   1 
ATOM   1621 H H    . ALA A 1 106 ? 36.85915 -8.27711  9.62455  1.000 9.42488   ? 103 ALA A H    1 
ATOM   1622 H HA   . ALA A 1 106 ? 39.44915 -8.46102  10.51718 1.000 6.73865   ? 103 ALA A HA   1 
ATOM   1623 H HB1  . ALA A 1 106 ? 39.23521 -6.49474  11.72016 1.000 7.83642   ? 103 ALA A HB1  1 
ATOM   1624 H HB2  . ALA A 1 106 ? 38.97157 -6.17257  10.18712 1.000 7.83642   ? 103 ALA A HB2  1 
ATOM   1625 H HB3  . ALA A 1 106 ? 37.74913 -6.30062  11.19348 1.000 7.83642   ? 103 ALA A HB3  1 
ATOM   1626 N N    . ALA A 1 107 ? 38.70758 -9.59745  12.61968 1.000 3.62008   ? 104 ALA A N    1 
ATOM   1627 C CA   . ALA A 1 107 ? 38.18715 -10.36923 13.75146 1.000 2.65523   ? 104 ALA A CA   1 
ATOM   1628 C C    . ALA A 1 107 ? 39.23917 -10.36775 14.86826 1.000 2.10811   ? 104 ALA A C    1 
ATOM   1629 O O    . ALA A 1 107 ? 40.44985 -10.38725 14.59836 1.000 5.55113   ? 104 ALA A O    1 
ATOM   1630 C CB   . ALA A 1 107 ? 37.81175 -11.79354 13.33774 1.000 1.66001   ? 104 ALA A CB   1 
ATOM   1631 H H    . ALA A 1 107 ? 39.55927 -9.65699  12.51639 1.000 4.34412   ? 104 ALA A H    1 
ATOM   1632 H HA   . ALA A 1 107 ? 37.38182 -9.95741  14.10180 1.000 3.18629   ? 104 ALA A HA   1 
ATOM   1633 H HB1  . ALA A 1 107 ? 37.50347 -12.27850 14.11920 1.000 1.99203   ? 104 ALA A HB1  1 
ATOM   1634 H HB2  . ALA A 1 107 ? 37.10606 -11.75380 12.67343 1.000 1.99203   ? 104 ALA A HB2  1 
ATOM   1635 H HB3  . ALA A 1 107 ? 38.59327 -12.23030 12.96441 1.000 1.99203   ? 104 ALA A HB3  1 
ATOM   1636 N N    . ILE A 1 108 ? 38.78824 -10.31354 16.11580 1.000 2.77115   ? 105 ILE A N    1 
ATOM   1637 C CA   . ILE A 1 108 ? 39.70535 -10.12922 17.23350 1.000 5.74005   ? 105 ILE A CA   1 
ATOM   1638 C C    . ILE A 1 108 ? 39.39269 -11.11163 18.36486 1.000 2.72396   ? 105 ILE A C    1 
ATOM   1639 O O    . ILE A 1 108 ? 38.23970 -11.45007 18.61974 1.000 3.62088   ? 105 ILE A O    1 
ATOM   1640 C CB   . ILE A 1 108 ? 39.65743 -8.65938  17.70492 1.000 3.37893   ? 105 ILE A CB   1 
ATOM   1641 C CG1  . ILE A 1 108 ? 40.57698 -8.43695  18.91311 1.000 0.00008   ? 105 ILE A CG1  1 
ATOM   1642 C CG2  . ILE A 1 108 ? 38.26670 -8.27754  18.21324 1.000 7.55979   ? 105 ILE A CG2  1 
ATOM   1643 C CD1  . ILE A 1 108 ? 40.91324 -6.98229  19.28150 1.000 5.50571   ? 105 ILE A CD1  1 
ATOM   1644 H H    . ILE A 1 108 ? 37.96021 -10.38069 16.33820 1.000 3.32539   ? 105 ILE A H    1 
ATOM   1645 H HA   . ILE A 1 108 ? 40.60822 -10.35035 16.95633 1.000 6.88808   ? 105 ILE A HA   1 
ATOM   1646 H HB   . ILE A 1 108 ? 39.92268 -8.13482  16.93331 1.000 4.05473   ? 105 ILE A HB   1 
ATOM   1647 H HG12 . ILE A 1 108 ? 40.15071 -8.83241  19.68951 1.000 0.00008   ? 105 ILE A HG12 1 
ATOM   1648 H HG13 . ILE A 1 108 ? 41.41913 -8.88352  18.73353 1.000 0.00008   ? 105 ILE A HG13 1 
ATOM   1649 H HG21 . ILE A 1 108 ? 38.26445 -7.33703  18.45061 1.000 9.07177   ? 105 ILE A HG21 1 
ATOM   1650 H HG22 . ILE A 1 108 ? 37.61758 -8.44319  17.51174 1.000 9.07177   ? 105 ILE A HG22 1 
ATOM   1651 H HG23 . ILE A 1 108 ? 38.05642 -8.81581  18.99231 1.000 9.07177   ? 105 ILE A HG23 1 
ATOM   1652 H HD11 . ILE A 1 108 ? 41.58914 -6.98088  19.97724 1.000 6.60686   ? 105 ILE A HD11 1 
ATOM   1653 H HD12 . ILE A 1 108 ? 41.24853 -6.52643  18.49368 1.000 6.60686   ? 105 ILE A HD12 1 
ATOM   1654 H HD13 . ILE A 1 108 ? 40.10920 -6.54338  19.60055 1.000 6.60686   ? 105 ILE A HD13 1 
ATOM   1655 N N    . CYS A 1 109 ? 40.46020 -11.65099 18.94778 1.000 3.50795   ? 106 CYS A N    1 
ATOM   1656 C CA   . CYS A 1 109 ? 40.41139 -12.43391 20.18104 1.000 1.36156   ? 106 CYS A CA   1 
ATOM   1657 C C    . CYS A 1 109 ? 39.80542 -13.80463 19.86851 1.000 4.82763   ? 106 CYS A C    1 
ATOM   1658 O O    . CYS A 1 109 ? 40.49128 -14.63308 19.26520 1.000 3.71812   ? 106 CYS A O    1 
ATOM   1659 C CB   . CYS A 1 109 ? 39.66685 -11.67411 21.27994 1.000 5.45604   ? 106 CYS A CB   1 
ATOM   1660 S SG   . CYS A 1 109 ? 40.08122 -12.40058 22.87638 1.000 8.51555   ? 106 CYS A SG   1 
ATOM   1661 H H    . CYS A 1 109 ? 41.25834 -11.57539 18.63655 1.000 4.20956   ? 106 CYS A H    1 
ATOM   1662 H HA   . CYS A 1 109 ? 41.30019 -12.58242 20.54003 1.000 1.63389   ? 106 CYS A HA   1 
ATOM   1663 H HB2  . CYS A 1 109 ? 39.93545 -10.74204 21.27707 1.000 6.54727   ? 106 CYS A HB2  1 
ATOM   1664 H HB3  . CYS A 1 109 ? 38.70964 -11.74396 21.13930 1.000 6.54727   ? 106 CYS A HB3  1 
ATOM   1665 N N    . ALA A 1 110 ? 38.57340 -14.09678 20.28906 1.000 4.48626   ? 107 ALA A N    1 
ATOM   1666 C CA   . ALA A 1 110 ? 37.98986 -15.33495 19.83664 1.000 1.68026   ? 107 ALA A CA   1 
ATOM   1667 C C    . ALA A 1 110 ? 37.26142 -15.19230 18.50282 1.000 6.86227   ? 107 ALA A C    1 
ATOM   1668 O O    . ALA A 1 110 ? 36.93230 -16.19727 17.89549 1.000 3.36887   ? 107 ALA A O    1 
ATOM   1669 C CB   . ALA A 1 110 ? 36.99787 -15.89614 20.85754 1.000 7.43102   ? 107 ALA A CB   1 
ATOM   1670 H H    . ALA A 1 110 ? 38.08917 -13.61253 20.80928 1.000 5.38353   ? 107 ALA A H    1 
ATOM   1671 H HA   . ALA A 1 110 ? 38.71393 -15.97363 19.74330 1.000 2.01633   ? 107 ALA A HA   1 
ATOM   1672 H HB1  . ALA A 1 110 ? 36.62051 -16.71994 20.51134 1.000 8.91724   ? 107 ALA A HB1  1 
ATOM   1673 H HB2  . ALA A 1 110 ? 37.46541 -16.07040 21.68937 1.000 8.91724   ? 107 ALA A HB2  1 
ATOM   1674 H HB3  . ALA A 1 110 ? 36.29347 -15.24556 21.00403 1.000 8.91724   ? 107 ALA A HB3  1 
ATOM   1675 N N    . GLY A 1 111 ? 37.06503 -13.96207 18.04012 1.000 0.40456   ? 108 GLY A N    1 
ATOM   1676 C CA   . GLY A 1 111 ? 36.33761 -13.72360 16.82113 1.000 5.91010   ? 108 GLY A CA   1 
ATOM   1677 C C    . GLY A 1 111 ? 36.82473 -14.52235 15.63876 1.000 4.25083   ? 108 GLY A C    1 
ATOM   1678 O O    . GLY A 1 111 ? 36.00203 -14.95898 14.81260 1.000 7.63624   ? 108 GLY A O    1 
ATOM   1679 H H    . GLY A 1 111 ? 37.34942 -13.24702 18.42408 1.000 0.48549   ? 108 GLY A H    1 
ATOM   1680 H HA2  . GLY A 1 111 ? 35.40434 -13.94487 16.96584 1.000 7.09214   ? 108 GLY A HA2  1 
ATOM   1681 H HA3  . GLY A 1 111 ? 36.40770 -12.78309 16.59437 1.000 7.09214   ? 108 GLY A HA3  1 
ATOM   1682 N N    . PRO A 1 112 ? 38.14191 -14.70996 15.49096 1.000 2.54248   ? 109 PRO A N    1 
ATOM   1683 C CA   . PRO A 1 112 ? 38.62207 -15.35154 14.27091 1.000 2.24106   ? 109 PRO A CA   1 
ATOM   1684 C C    . PRO A 1 112 ? 38.08548 -16.73869 14.12026 1.000 6.45848   ? 109 PRO A C    1 
ATOM   1685 O O    . PRO A 1 112 ? 38.04162 -17.28111 12.98851 1.000 6.84746   ? 109 PRO A O    1 
ATOM   1686 C CB   . PRO A 1 112 ? 40.12998 -15.32532 14.44637 1.000 1.27221   ? 109 PRO A CB   1 
ATOM   1687 C CG   . PRO A 1 112 ? 40.38612 -14.10968 15.21171 1.000 2.13029   ? 109 PRO A CG   1 
ATOM   1688 C CD   . PRO A 1 112 ? 39.25175 -14.14465 16.25262 1.000 4.96853   ? 109 PRO A CD   1 
ATOM   1689 H HA   . PRO A 1 112 ? 38.40109 -14.83361 13.48109 1.000 2.68929   ? 109 PRO A HA   1 
ATOM   1690 H HB2  . PRO A 1 112 ? 40.42176 -16.11218 14.93281 1.000 1.52666   ? 109 PRO A HB2  1 
ATOM   1691 H HB3  . PRO A 1 112 ? 40.56489 -15.29065 13.58003 1.000 1.52666   ? 109 PRO A HB3  1 
ATOM   1692 H HG2  . PRO A 1 112 ? 41.25927 -14.14690 15.63257 1.000 2.55636   ? 109 PRO A HG2  1 
ATOM   1693 H HG3  . PRO A 1 112 ? 40.32536 -13.32671 14.64236 1.000 2.55636   ? 109 PRO A HG3  1 
ATOM   1694 H HD2  . PRO A 1 112 ? 39.48487 -14.71359 17.00286 1.000 5.96225   ? 109 PRO A HD2  1 
ATOM   1695 H HD3  . PRO A 1 112 ? 39.03959 -13.25177 16.56671 1.000 5.96225   ? 109 PRO A HD3  1 
ATOM   1696 N N    . THR A 1 113 ? 37.62313 -17.30977 15.21428 1.000 4.71063   ? 110 THR A N    1 
ATOM   1697 C CA   . THR A 1 113 ? 37.20651 -18.70248 15.12054 1.000 4.58859   ? 110 THR A CA   1 
ATOM   1698 C C    . THR A 1 113 ? 35.94480 -18.83438 14.31102 1.000 9.56953   ? 110 THR A C    1 
ATOM   1699 O O    . THR A 1 113 ? 35.65613 -19.91817 13.82947 1.000 10.08782  ? 110 THR A O    1 
ATOM   1700 C CB   . THR A 1 113 ? 36.97839 -19.35794 16.49142 1.000 11.64044  ? 110 THR A CB   1 
ATOM   1701 O OG1  . THR A 1 113 ? 35.91493 -18.76134 17.22053 1.000 10.96748  ? 110 THR A OG1  1 
ATOM   1702 C CG2  . THR A 1 113 ? 38.22359 -19.26955 17.32823 1.000 14.60095  ? 110 THR A CG2  1 
ATOM   1703 H H    . THR A 1 113 ? 37.54265 -16.93707 15.98513 1.000 5.65277   ? 110 THR A H    1 
ATOM   1704 H HA   . THR A 1 113 ? 37.93524 -19.18926 14.70471 1.000 5.50633   ? 110 THR A HA   1 
ATOM   1705 H HB   . THR A 1 113 ? 36.74500 -20.28457 16.32476 1.000 13.96854  ? 110 THR A HB   1 
ATOM   1706 H HG1  . THR A 1 113 ? 36.05731 -17.93890 17.31505 1.000 13.16100  ? 110 THR A HG1  1 
ATOM   1707 H HG21 . THR A 1 113 ? 38.41315 -18.34308 17.54413 1.000 17.52115  ? 110 THR A HG21 1 
ATOM   1708 H HG22 . THR A 1 113 ? 38.10537 -19.76704 18.15251 1.000 17.52115  ? 110 THR A HG22 1 
ATOM   1709 H HG23 . THR A 1 113 ? 38.97690 -19.64001 16.84224 1.000 17.52115  ? 110 THR A HG23 1 
ATOM   1710 N N    . ALA A 1 114 ? 35.20713 -17.73893 14.12131 1.000 5.05696   ? 111 ALA A N    1 
ATOM   1711 C CA   . ALA A 1 114 ? 34.04986 -17.81834 13.25142 1.000 7.53868   ? 111 ALA A CA   1 
ATOM   1712 C C    . ALA A 1 114 ? 34.47372 -17.94559 11.80173 1.000 9.99406   ? 111 ALA A C    1 
ATOM   1713 O O    . ALA A 1 114 ? 33.65899 -18.34106 10.94253 1.000 10.49231  ? 111 ALA A O    1 
ATOM   1714 C CB   . ALA A 1 114 ? 33.20978 -16.56794 13.44253 1.000 10.26704  ? 111 ALA A CB   1 
ATOM   1715 H H    . ALA A 1 114 ? 35.35522 -16.96890 14.47448 1.000 6.06837   ? 111 ALA A H    1 
ATOM   1716 H HA   . ALA A 1 114 ? 33.50463 -18.58802 13.47771 1.000 9.04643   ? 111 ALA A HA   1 
ATOM   1717 H HB1  . ALA A 1 114 ? 32.45467 -16.59882 12.83446 1.000 12.32046  ? 111 ALA A HB1  1 
ATOM   1718 H HB2  . ALA A 1 114 ? 32.89499 -16.53607 14.35948 1.000 12.32046  ? 111 ALA A HB2  1 
ATOM   1719 H HB3  . ALA A 1 114 ? 33.75554 -15.78878 13.25290 1.000 12.32046  ? 111 ALA A HB3  1 
ATOM   1720 N N    . LEU A 1 115 ? 35.67545 -17.52948 11.50728 1.000 4.19296   ? 112 LEU A N    1 
ATOM   1721 C CA   . LEU A 1 115 ? 36.14002 -17.66454 10.14972 1.000 2.06285   ? 112 LEU A CA   1 
ATOM   1722 C C    . LEU A 1 115 ? 36.30234 -19.11771 9.82942  1.000 11.22300  ? 112 LEU A C    1 
ATOM   1723 O O    . LEU A 1 115 ? 35.99688 -19.58011 8.70970  1.000 6.95409   ? 112 LEU A O    1 
ATOM   1724 C CB   . LEU A 1 115 ? 37.49217 -16.97171 9.99124  1.000 5.13517   ? 112 LEU A CB   1 
ATOM   1725 C CG   . LEU A 1 115 ? 37.42474 -15.50237 10.33784 1.000 6.37792   ? 112 LEU A CG   1 
ATOM   1726 C CD1  . LEU A 1 115 ? 38.74362 -14.85948 10.11606 1.000 14.23170  ? 112 LEU A CD1  1 
ATOM   1727 C CD2  . LEU A 1 115 ? 36.48860 -14.78958 9.46685  1.000 10.11741  ? 112 LEU A CD2  1 
ATOM   1728 H H    . LEU A 1 115 ? 36.23173 -17.17338 12.05805 1.000 5.03157   ? 112 LEU A H    1 
ATOM   1729 H HA   . LEU A 1 115 ? 35.50576 -17.24999 9.54410  1.000 2.47544   ? 112 LEU A HA   1 
ATOM   1730 H HB2  . LEU A 1 115 ? 38.13587 -17.39349 10.58171 1.000 6.16222   ? 112 LEU A HB2  1 
ATOM   1731 H HB3  . LEU A 1 115 ? 37.78420 -17.05300 9.06983  1.000 6.16222   ? 112 LEU A HB3  1 
ATOM   1732 H HG   . LEU A 1 115 ? 37.14517 -15.44344 11.26481 1.000 7.65352   ? 112 LEU A HG   1 
ATOM   1733 H HD11 . LEU A 1 115 ? 38.67074 -13.91272 10.31415 1.000 17.07806  ? 112 LEU A HD11 1 
ATOM   1734 H HD12 . LEU A 1 115 ? 39.39795 -15.27066 10.70230 1.000 17.07806  ? 112 LEU A HD12 1 
ATOM   1735 H HD13 . LEU A 1 115 ? 39.00422 -14.98459 9.19014  1.000 17.07806  ? 112 LEU A HD13 1 
ATOM   1736 H HD21 . LEU A 1 115 ? 36.58649 -13.83546 9.61168  1.000 12.14091  ? 112 LEU A HD21 1 
ATOM   1737 H HD22 . LEU A 1 115 ? 36.68942 -15.00622 8.54293  1.000 12.14091  ? 112 LEU A HD22 1 
ATOM   1738 H HD23 . LEU A 1 115 ? 35.58404 -15.06575 9.68227  1.000 12.14091  ? 112 LEU A HD23 1 
ATOM   1739 N N    . LEU A 1 116 ? 36.80977 -19.85506 10.80577 1.000 5.42502   ? 113 LEU A N    1 
ATOM   1740 C CA   . LEU A 1 116 ? 36.98767 -21.26744 10.59644 1.000 9.44114   ? 113 LEU A CA   1 
ATOM   1741 C C    . LEU A 1 116 ? 35.63910 -21.94196 10.43441 1.000 10.00738  ? 113 LEU A C    1 
ATOM   1742 O O    . LEU A 1 116 ? 35.43593 -22.72390 9.51172  1.000 13.18203  ? 113 LEU A O    1 
ATOM   1743 C CB   . LEU A 1 116 ? 37.76132 -21.85097 11.75592 1.000 4.29235   ? 113 LEU A CB   1 
ATOM   1744 C CG   . LEU A 1 116 ? 37.72617 -23.36503 11.67193 1.000 16.53080  ? 113 LEU A CG   1 
ATOM   1745 C CD1  . LEU A 1 116 ? 38.49541 -23.98259 10.46909 1.000 7.41235   ? 113 LEU A CD1  1 
ATOM   1746 C CD2  . LEU A 1 116 ? 38.38919 -23.91533 12.89681 1.000 13.90356  ? 113 LEU A CD2  1 
ATOM   1747 H H    . LEU A 1 116 ? 37.05121 -19.56289 11.57775 1.000 6.51004   ? 113 LEU A H    1 
ATOM   1748 H HA   . LEU A 1 116 ? 37.50207 -21.42554 9.78941  1.000 11.32939  ? 113 LEU A HA   1 
ATOM   1749 H HB2  . LEU A 1 116 ? 38.68406 -21.55439 11.71718 1.000 5.15084   ? 113 LEU A HB2  1 
ATOM   1750 H HB3  . LEU A 1 116 ? 37.35811 -21.57219 12.59295 1.000 5.15084   ? 113 LEU A HB3  1 
ATOM   1751 H HG   . LEU A 1 116 ? 36.79081 -23.60254 11.57395 1.000 19.83698  ? 113 LEU A HG   1 
ATOM   1752 H HD11 . LEU A 1 116 ? 38.43866 -24.94955 10.52084 1.000 8.89483   ? 113 LEU A HD11 1 
ATOM   1753 H HD12 . LEU A 1 116 ? 38.09272 -23.67133 9.64334  1.000 8.89483   ? 113 LEU A HD12 1 
ATOM   1754 H HD13 . LEU A 1 116 ? 39.42331 -23.70300 10.51054 1.000 8.89483   ? 113 LEU A HD13 1 
ATOM   1755 H HD21 . LEU A 1 116 ? 38.40916 -24.88329 12.83723 1.000 16.68429  ? 113 LEU A HD21 1 
ATOM   1756 H HD22 . LEU A 1 116 ? 39.29351 -23.56842 12.94927 1.000 16.68429  ? 113 LEU A HD22 1 
ATOM   1757 H HD23 . LEU A 1 116 ? 37.88432 -23.64240 13.67881 1.000 16.68429  ? 113 LEU A HD23 1 
ATOM   1758 N N    . ALA A 1 117 ? 34.70740 -21.63873 11.31393 1.000 8.72143   ? 114 ALA A N    1 
ATOM   1759 C CA   . ALA A 1 117 ? 33.39951 -22.26501 11.20564 1.000 10.29525  ? 114 ALA A CA   1 
ATOM   1760 C C    . ALA A 1 117 ? 32.77258 -22.05427 9.83523  1.000 18.22290  ? 114 ALA A C    1 
ATOM   1761 O O    . ALA A 1 117 ? 32.01148 -22.89957 9.36900  1.000 16.31663  ? 114 ALA A O    1 
ATOM   1762 C CB   . ALA A 1 117 ? 32.50254 -21.68489 12.27791 1.000 11.37061  ? 114 ALA A CB   1 
ATOM   1763 H H    . ALA A 1 117 ? 34.79933 -21.08818 11.96819 1.000 10.46574  ? 114 ALA A H    1 
ATOM   1764 H HA   . ALA A 1 117 ? 33.48981 -23.22184 11.33691 1.000 12.35432  ? 114 ALA A HA   1 
ATOM   1765 H HB1  . ALA A 1 117 ? 31.62449 -22.09132 12.20907 1.000 13.64474  ? 114 ALA A HB1  1 
ATOM   1766 H HB2  . ALA A 1 117 ? 32.88735 -21.87415 13.14797 1.000 13.64474  ? 114 ALA A HB2  1 
ATOM   1767 H HB3  . ALA A 1 117 ? 32.43433 -20.72607 12.14787 1.000 13.64474  ? 114 ALA A HB3  1 
ATOM   1768 N N    . HIS A 1 118 ? 33.05302 -20.92751 9.20595  1.000 7.77512   ? 115 HIS A N    1 
ATOM   1769 C CA   . HIS A 1 118 ? 32.39286 -20.55095 7.97816  1.000 17.47038  ? 115 HIS A CA   1 
ATOM   1770 C C    . HIS A 1 118 ? 33.27259 -20.73646 6.76445  1.000 15.76427  ? 115 HIS A C    1 
ATOM   1771 O O    . HIS A 1 118 ? 32.93161 -20.24535 5.67145  1.000 9.92447   ? 115 HIS A O    1 
ATOM   1772 C CB   . HIS A 1 118 ? 31.96316 -19.10356 8.08973  1.000 8.94286   ? 115 HIS A CB   1 
ATOM   1773 C CG   . HIS A 1 118 ? 30.90381 -18.90036 9.10657  1.000 15.42441  ? 115 HIS A CG   1 
ATOM   1774 N ND1  . HIS A 1 118 ? 29.82720 -19.74933 9.22185  1.000 14.96128  ? 115 HIS A ND1  1 
ATOM   1775 C CD2  . HIS A 1 118 ? 30.74047 -17.94511 10.05282 1.000 11.81339  ? 115 HIS A CD2  1 
ATOM   1776 C CE1  . HIS A 1 118 ? 29.04615 -19.33653 10.20649 1.000 7.84685   ? 115 HIS A CE1  1 
ATOM   1777 N NE2  . HIS A 1 118 ? 29.55794 -18.21143 10.69553 1.000 8.17408   ? 115 HIS A NE2  1 
ATOM   1778 H H    . HIS A 1 118 ? 33.63425 -20.35528 9.47859  1.000 9.33016   ? 115 HIS A H    1 
ATOM   1779 H HA   . HIS A 1 118 ? 31.60760 -21.10552 7.84882  1.000 20.96447  ? 115 HIS A HA   1 
ATOM   1780 H HB2  . HIS A 1 118 ? 32.72936 -18.56465 8.34157  1.000 10.73145  ? 115 HIS A HB2  1 
ATOM   1781 H HB3  . HIS A 1 118 ? 31.61784 -18.80913 7.23243  1.000 10.73145  ? 115 HIS A HB3  1 
ATOM   1782 H HD2  . HIS A 1 118 ? 31.32078 -17.24106 10.23299 1.000 14.17608  ? 115 HIS A HD2  1 
ATOM   1783 H HE1  . HIS A 1 118 ? 28.27357 -19.75975 10.50462 1.000 9.41623   ? 115 HIS A HE1  1 
ATOM   1784 H HE2  . HIS A 1 118 ? 29.20528 -17.72905 11.31403 1.000 9.80891   ? 115 HIS A HE2  1 
ATOM   1785 N N    . GLU A 1 119 ? 34.44128 -21.32170 6.96800  1.000 12.68058  ? 116 GLU A N    1 
ATOM   1786 C CA   . GLU A 1 119 ? 35.38977 -21.69568 5.91215  1.000 14.12353  ? 116 GLU A CA   1 
ATOM   1787 C C    . GLU A 1 119 ? 35.86240 -20.47704 5.15832  1.000 19.22433  ? 116 GLU A C    1 
ATOM   1788 O O    . GLU A 1 119 ? 35.88876 -20.42578 3.92206  1.000 13.40069  ? 116 GLU A O    1 
ATOM   1789 C CB   . GLU A 1 119 ? 34.79005 -22.72845 4.94583  1.000 24.98394  ? 116 GLU A CB   1 
ATOM   1790 C CG   . GLU A 1 119 ? 34.35467 -24.02472 5.63677  1.000 36.03950  ? 116 GLU A CG   1 
ATOM   1791 C CD   . GLU A 1 119 ? 33.96497 -25.19061 4.67142  1.000 46.23206  ? 116 GLU A CD   1 
ATOM   1792 O OE1  . GLU A 1 119 ? 33.65693 -24.99172 3.45997  1.000 42.26666  ? 116 GLU A OE1  1 
ATOM   1793 O OE2  . GLU A 1 119 ? 34.00952 -26.33824 5.15674  1.000 33.91085  ? 116 GLU A OE2  1 
ATOM   1794 H H    . GLU A 1 119 ? 34.73140 -21.52757 7.75098  1.000 15.21671  ? 116 GLU A H    1 
ATOM   1795 H HA   . GLU A 1 119 ? 36.15906 -22.10531 6.33792  1.000 16.94825  ? 116 GLU A HA   1 
ATOM   1796 H HB2  . GLU A 1 119 ? 34.00966 -22.34186 4.51869  1.000 29.98074  ? 116 GLU A HB2  1 
ATOM   1797 H HB3  . GLU A 1 119 ? 35.45544 -22.95592 4.27768  1.000 29.98074  ? 116 GLU A HB3  1 
ATOM   1798 H HG2  . GLU A 1 119 ? 35.08678 -24.33873 6.19022  1.000 43.24742  ? 116 GLU A HG2  1 
ATOM   1799 H HG3  . GLU A 1 119 ? 33.58004 -23.83362 6.18843  1.000 43.24742  ? 116 GLU A HG3  1 
ATOM   1800 N N    . ILE A 1 120 ? 36.26246 -19.47924 5.92937  1.000 15.43109  ? 117 ILE A N    1 
ATOM   1801 C CA   . ILE A 1 120 ? 36.62869 -18.19763 5.37640  1.000 2.52566   ? 117 ILE A CA   1 
ATOM   1802 C C    . ILE A 1 120 ? 38.13450 -18.03024 5.45541  1.000 14.14985  ? 117 ILE A C    1 
ATOM   1803 O O    . ILE A 1 120 ? 38.73049 -18.18727 6.54334  1.000 11.37654  ? 117 ILE A O    1 
ATOM   1804 C CB   . ILE A 1 120 ? 35.94041 -17.04421 6.11392  1.000 4.46143   ? 117 ILE A CB   1 
ATOM   1805 C CG1  . ILE A 1 120 ? 34.42304 -17.22875 6.03367  1.000 23.24164  ? 117 ILE A CG1  1 
ATOM   1806 C CG2  . ILE A 1 120 ? 36.55511 -15.78223 5.52505  1.000 14.29261  ? 117 ILE A CG2  1 
ATOM   1807 C CD1  . ILE A 1 120 ? 33.91522 -17.00289 4.64353  1.000 21.41881  ? 117 ILE A CD1  1 
ATOM   1808 H H    . ILE A 1 120 ? 36.32891 -19.52648 6.78550  1.000 18.51733  ? 117 ILE A H    1 
ATOM   1809 H HA   . ILE A 1 120 ? 36.36310 -18.18572 4.44355  1.000 3.03081   ? 117 ILE A HA   1 
ATOM   1810 H HB   . ILE A 1 120 ? 36.08513 -17.00106 7.07209  1.000 5.35373   ? 117 ILE A HB   1 
ATOM   1811 H HG12 . ILE A 1 120 ? 34.19576 -18.13373 6.29871  1.000 27.88999  ? 117 ILE A HG12 1 
ATOM   1812 H HG13 . ILE A 1 120 ? 33.99103 -16.59177 6.62402  1.000 27.88999  ? 117 ILE A HG13 1 
ATOM   1813 H HG21 . ILE A 1 120 ? 35.98084 -15.02714 5.72744  1.000 17.15114  ? 117 ILE A HG21 1 
ATOM   1814 H HG22 . ILE A 1 120 ? 37.43180 -15.64545 5.91697  1.000 17.15114  ? 117 ILE A HG22 1 
ATOM   1815 H HG23 . ILE A 1 120 ? 36.63525 -15.88867 4.56425  1.000 17.15114  ? 117 ILE A HG23 1 
ATOM   1816 H HD11 . ILE A 1 120 ? 32.95049 -17.10378 4.63945  1.000 25.70259  ? 117 ILE A HD11 1 
ATOM   1817 H HD12 . ILE A 1 120 ? 34.15525 -16.10640 4.36140  1.000 25.70259  ? 117 ILE A HD12 1 
ATOM   1818 H HD13 . ILE A 1 120 ? 34.31857 -17.65556 4.05004  1.000 25.70259  ? 117 ILE A HD13 1 
ATOM   1819 N N    . GLY A 1 121 ? 38.73908 -17.62924 4.35309  1.000 8.65596   ? 118 GLY A N    1 
ATOM   1820 C CA   . GLY A 1 121 ? 40.15738 -17.26778 4.38617  1.000 11.13710  ? 118 GLY A CA   1 
ATOM   1821 C C    . GLY A 1 121 ? 41.18084 -18.38074 4.55334  1.000 10.20635  ? 118 GLY A C    1 
ATOM   1822 O O    . GLY A 1 121 ? 42.32473 -18.09027 4.97006  1.000 6.36749   ? 118 GLY A O    1 
ATOM   1823 H H    . GLY A 1 121 ? 38.36424 -17.55627 3.58253  1.000 10.38716  ? 118 GLY A H    1 
ATOM   1824 H HA2  . GLY A 1 121 ? 40.36805 -16.81515 3.55452  1.000 13.36453  ? 118 GLY A HA2  1 
ATOM   1825 H HA3  . GLY A 1 121 ? 40.28975 -16.65150 5.12345  1.000 13.36453  ? 118 GLY A HA3  1 
ATOM   1826 N N    . PHE A 1 122 ? 40.85022 -19.64822 4.24666  1.000 9.97209   ? 119 PHE A N    1 
ATOM   1827 C CA   . PHE A 1 122 ? 41.81735 -20.74257 4.43318  1.000 6.21699   ? 119 PHE A CA   1 
ATOM   1828 C C    . PHE A 1 122 ? 43.13177 -20.45031 3.72610  1.000 12.77920  ? 119 PHE A C    1 
ATOM   1829 O O    . PHE A 1 122 ? 43.15480 -19.95490 2.60091  1.000 6.72679   ? 119 PHE A O    1 
ATOM   1830 C CB   . PHE A 1 122 ? 41.25902 -22.08683 3.93973  1.000 15.41559  ? 119 PHE A CB   1 
ATOM   1831 C CG   . PHE A 1 122 ? 40.22985 -22.72880 4.86091  1.000 10.14015  ? 119 PHE A CG   1 
ATOM   1832 C CD1  . PHE A 1 122 ? 39.75190 -22.03527 5.98854  1.000 12.71360  ? 119 PHE A CD1  1 
ATOM   1833 C CD2  . PHE A 1 122 ? 39.71251 -23.99060 4.60969  1.000 14.70529  ? 119 PHE A CD2  1 
ATOM   1834 C CE1  . PHE A 1 122 ? 38.74400 -22.59808 6.81872  1.000 14.16231  ? 119 PHE A CE1  1 
ATOM   1835 C CE2  . PHE A 1 122 ? 38.73802 -24.55346 5.44016  1.000 14.79089  ? 119 PHE A CE2  1 
ATOM   1836 C CZ   . PHE A 1 122 ? 38.28491 -23.87840 6.55961  1.000 10.16256  ? 119 PHE A CZ   1 
ATOM   1837 H H    . PHE A 1 122 ? 40.08741 -19.89479 3.93534  1.000 11.96652  ? 119 PHE A H    1 
ATOM   1838 H HA   . PHE A 1 122 ? 41.98554 -20.82139 5.38523  1.000 7.46040   ? 119 PHE A HA   1 
ATOM   1839 H HB2  . PHE A 1 122 ? 40.83284 -21.94600 3.07983  1.000 18.49872  ? 119 PHE A HB2  1 
ATOM   1840 H HB3  . PHE A 1 122 ? 41.99602 -22.71056 3.84655  1.000 18.49872  ? 119 PHE A HB3  1 
ATOM   1841 H HD1  . PHE A 1 122 ? 40.10001 -21.19757 6.19342  1.000 15.25634  ? 119 PHE A HD1  1 
ATOM   1842 H HD2  . PHE A 1 122 ? 40.01927 -24.47158 3.87522  1.000 17.64636  ? 119 PHE A HD2  1 
ATOM   1843 H HE1  . PHE A 1 122 ? 38.39599 -22.11022 7.52990  1.000 16.99479  ? 119 PHE A HE1  1 
ATOM   1844 H HE2  . PHE A 1 122 ? 38.39033 -25.39185 5.23739  1.000 17.74909  ? 119 PHE A HE2  1 
ATOM   1845 H HZ   . PHE A 1 122 ? 37.67562 -24.28218 7.13462  1.000 12.19509  ? 119 PHE A HZ   1 
ATOM   1846 N N    . GLY A 1 123 ? 44.24521 -20.80931 4.38848  1.000 10.10104  ? 120 GLY A N    1 
ATOM   1847 C CA   . GLY A 1 123 ? 45.57173 -20.54598 3.86796  1.000 4.61264   ? 120 GLY A CA   1 
ATOM   1848 C C    . GLY A 1 123 ? 46.23995 -19.27004 4.35741  1.000 11.91917  ? 120 GLY A C    1 
ATOM   1849 O O    . GLY A 1 123 ? 47.39007 -19.04171 4.04723  1.000 10.82083  ? 120 GLY A O    1 
ATOM   1850 H H    . GLY A 1 123 ? 44.24483 -21.21065 5.14909  1.000 12.12126  ? 120 GLY A H    1 
ATOM   1851 H HA2  . GLY A 1 123 ? 46.14821 -21.28746 4.11038  1.000 5.53518   ? 120 GLY A HA2  1 
ATOM   1852 H HA3  . GLY A 1 123 ? 45.51585 -20.49241 2.90106  1.000 5.53518   ? 120 GLY A HA3  1 
ATOM   1853 N N    . SER A 1 124 ? 45.50530 -18.40433 5.04685  1.000 6.62354   ? 121 SER A N    1 
ATOM   1854 C CA   . SER A 1 124 ? 45.92194 -17.11173 5.54398  1.000 12.29672  ? 121 SER A CA   1 
ATOM   1855 C C    . SER A 1 124 ? 46.67064 -17.27318 6.85868  1.000 5.99612   ? 121 SER A C    1 
ATOM   1856 O O    . SER A 1 124 ? 46.41742 -18.21121 7.62380  1.000 9.03659   ? 121 SER A O    1 
ATOM   1857 C CB   . SER A 1 124 ? 44.71144 -16.20347 5.81520  1.000 13.80093  ? 121 SER A CB   1 
ATOM   1858 O OG   . SER A 1 124 ? 43.92417 -15.89672 4.66576  1.000 15.53108  ? 121 SER A OG   1 
ATOM   1859 H H    . SER A 1 124 ? 44.68621 -18.56129 5.25674  1.000 7.94827   ? 121 SER A H    1 
ATOM   1860 H HA   . SER A 1 124 ? 46.49113 -16.69793 4.87638  1.000 14.75608  ? 121 SER A HA   1 
ATOM   1861 H HB2  . SER A 1 124 ? 44.14005 -16.64995 6.45946  1.000 16.56114  ? 121 SER A HB2  1 
ATOM   1862 H HB3  . SER A 1 124 ? 45.03970 -15.36902 6.18511  1.000 16.56114  ? 121 SER A HB3  1 
ATOM   1863 H HG   . SER A 1 124 ? 43.64743 -16.60536 4.30962  1.000 18.63731  ? 121 SER A HG   1 
ATOM   1864 N N    . LYS A 1 125 ? 47.59179 -16.34601 7.09872  1.000 4.84702   ? 122 LYS A N    1 
ATOM   1865 C CA   . LYS A 1 125 ? 48.21393 -16.17233 8.39225  1.000 5.59800   ? 122 LYS A CA   1 
ATOM   1866 C C    . LYS A 1 125 ? 47.22929 -15.41100 9.29482  1.000 8.97287   ? 122 LYS A C    1 
ATOM   1867 O O    . LYS A 1 125 ? 46.80885 -14.31016 8.94575  1.000 8.15915   ? 122 LYS A O    1 
ATOM   1868 C CB   . LYS A 1 125 ? 49.51517 -15.39674 8.25263  1.000 7.45921   ? 122 LYS A CB   1 
ATOM   1869 C CG   . LYS A 1 125 ? 50.34597 -15.37955 9.54496  1.000 19.41882  ? 122 LYS A CG   1 
ATOM   1870 C CD   . LYS A 1 125 ? 51.75861 -14.82343 9.39139  1.000 30.67775  ? 122 LYS A CD   1 
ATOM   1871 C CE   . LYS A 1 125 ? 52.61529 -15.67459 8.43465  1.000 27.19979  ? 122 LYS A CE   1 
ATOM   1872 N NZ   . LYS A 1 125 ? 54.00553 -15.07267 8.32143  1.000 37.42666  ? 122 LYS A NZ   1 
ATOM   1873 H H    . LYS A 1 125 ? 47.87828 -15.79123 6.50733  1.000 5.81644   ? 122 LYS A H    1 
ATOM   1874 H HA   . LYS A 1 125 ? 48.42648 -17.03043 8.79148  1.000 6.71762   ? 122 LYS A HA   1 
ATOM   1875 H HB2  . LYS A 1 125 ? 50.05258 -15.80648 7.55678  1.000 8.95107   ? 122 LYS A HB2  1 
ATOM   1876 H HB3  . LYS A 1 125 ? 49.31038 -14.47854 8.01626  1.000 8.95107   ? 122 LYS A HB3  1 
ATOM   1877 H HG2  . LYS A 1 125 ? 49.88694 -14.83022 10.19951 1.000 23.30259  ? 122 LYS A HG2  1 
ATOM   1878 H HG3  . LYS A 1 125 ? 50.42571 -16.28907 9.87255  1.000 23.30259  ? 122 LYS A HG3  1 
ATOM   1879 H HD2  . LYS A 1 125 ? 51.70996 -13.92307 9.03378  1.000 36.81331  ? 122 LYS A HD2  1 
ATOM   1880 H HD3  . LYS A 1 125 ? 52.19343 -14.81299 10.25841 1.000 36.81331  ? 122 LYS A HD3  1 
ATOM   1881 H HE2  . LYS A 1 125 ? 52.69270 -16.57801 8.77924  1.000 32.63976  ? 122 LYS A HE2  1 
ATOM   1882 H HE3  . LYS A 1 125 ? 52.20805 -15.68903 7.55439  1.000 32.63976  ? 122 LYS A HE3  1 
ATOM   1883 H HZ1  . LYS A 1 125 ? 54.43322 -15.14609 9.09847  1.000 44.91201  ? 122 LYS A HZ1  1 
ATOM   1884 H HZ2  . LYS A 1 125 ? 54.47141 -15.49847 7.69394  1.000 44.91201  ? 122 LYS A HZ2  1 
ATOM   1885 H HZ3  . LYS A 1 125 ? 53.94763 -14.21162 8.10383  1.000 44.91201  ? 122 LYS A HZ3  1 
ATOM   1886 N N    . VAL A 1 126 ? 46.90993 -15.96373 10.48081 1.000 5.10764   ? 123 VAL A N    1 
ATOM   1887 C CA   . VAL A 1 126 ? 45.99156 -15.29803 11.41621 1.000 7.04579   ? 123 VAL A CA   1 
ATOM   1888 C C    . VAL A 1 126 ? 46.51572 -15.38502 12.83927 1.000 4.01446   ? 123 VAL A C    1 
ATOM   1889 O O    . VAL A 1 126 ? 47.34872 -16.22618 13.16165 1.000 10.77893  ? 123 VAL A O    1 
ATOM   1890 C CB   . VAL A 1 126 ? 44.60999 -15.96626 11.45590 1.000 9.40747   ? 123 VAL A CB   1 
ATOM   1891 C CG1  . VAL A 1 126 ? 44.03324 -16.00271 10.09460 1.000 10.90389  ? 123 VAL A CG1  1 
ATOM   1892 C CG2  . VAL A 1 126 ? 44.82555 -17.35487 12.01489 1.000 8.35065   ? 123 VAL A CG2  1 
ATOM   1893 H H    . VAL A 1 126 ? 47.21246 -16.71862 10.76048 1.000 6.12919   ? 123 VAL A H    1 
ATOM   1894 H HA   . VAL A 1 126 ? 45.94038 -14.37261 11.13007 1.000 8.45496   ? 123 VAL A HA   1 
ATOM   1895 H HB   . VAL A 1 126 ? 43.97779 -15.48191 12.00965 1.000 11.28899  ? 123 VAL A HB   1 
ATOM   1896 H HG11 . VAL A 1 126 ? 43.12723 -16.34557 10.14456 1.000 13.08469  ? 123 VAL A HG11 1 
ATOM   1897 H HG12 . VAL A 1 126 ? 44.02713 -15.10385 9.73004  1.000 13.08469  ? 123 VAL A HG12 1 
ATOM   1898 H HG13 . VAL A 1 126 ? 44.57589 -16.58207 9.53713  1.000 13.08469  ? 123 VAL A HG13 1 
ATOM   1899 H HG21 . VAL A 1 126 ? 44.08234 -17.92003 11.75195 1.000 10.02080  ? 123 VAL A HG21 1 
ATOM   1900 H HG22 . VAL A 1 126 ? 45.65466 -17.71268 11.66071 1.000 10.02080  ? 123 VAL A HG22 1 
ATOM   1901 H HG23 . VAL A 1 126 ? 44.87468 -17.30179 12.98219 1.000 10.02080  ? 123 VAL A HG23 1 
ATOM   1902 N N    . THR A 1 127 ? 45.96713 -14.54720 13.72141 1.000 7.71291   ? 124 THR A N    1 
ATOM   1903 C CA   . THR A 1 127 ? 46.24470 -14.69178 15.15089 1.000 1.91056   ? 124 THR A CA   1 
ATOM   1904 C C    . THR A 1 127 ? 44.91691 -14.72599 15.87856 1.000 3.71399   ? 124 THR A C    1 
ATOM   1905 O O    . THR A 1 127 ? 43.85418 -14.42441 15.31846 1.000 5.55568   ? 124 THR A O    1 
ATOM   1906 C CB   . THR A 1 127 ? 47.14390 -13.58344 15.73593 1.000 5.06277   ? 124 THR A CB   1 
ATOM   1907 O OG1  . THR A 1 127 ? 47.61098 -13.96370 17.06472 1.000 3.34783   ? 124 THR A OG1  1 
ATOM   1908 C CG2  . THR A 1 127 ? 46.42907 -12.30159 15.86620 1.000 4.12992   ? 124 THR A CG2  1 
ATOM   1909 H H    . THR A 1 127 ? 45.44004 -13.89865 13.51853 1.000 9.25550   ? 124 THR A H    1 
ATOM   1910 H HA   . THR A 1 127 ? 46.72718 -15.52235 15.28603 1.000 2.29268   ? 124 THR A HA   1 
ATOM   1911 H HB   . THR A 1 127 ? 47.89095 -13.46388 15.12887 1.000 6.07534   ? 124 THR A HB   1 
ATOM   1912 H HG1  . THR A 1 127 ? 47.93535 -14.73828 17.04447 1.000 4.01741   ? 124 THR A HG1  1 
ATOM   1913 H HG21 . THR A 1 127 ? 47.06432 -11.57776 15.98207 1.000 4.95591   ? 124 THR A HG21 1 
ATOM   1914 H HG22 . THR A 1 127 ? 45.90190 -12.13325 15.06954 1.000 4.95591   ? 124 THR A HG22 1 
ATOM   1915 H HG23 . THR A 1 127 ? 45.83813 -12.32790 16.63496 1.000 4.95591   ? 124 THR A HG23 1 
ATOM   1916 N N    . THR A 1 128 ? 44.98891 -15.19019 17.11372 1.000 4.76607   ? 125 THR A N    1 
ATOM   1917 C CA   . THR A 1 128 ? 43.82891 -15.25163 17.97556 1.000 5.25719   ? 125 THR A CA   1 
ATOM   1918 C C    . THR A 1 128 ? 44.26437 -14.95768 19.40178 1.000 8.46011   ? 125 THR A C    1 
ATOM   1919 O O    . THR A 1 128 ? 45.46042 -14.91787 19.70496 1.000 5.80570   ? 125 THR A O    1 
ATOM   1920 C CB   . THR A 1 128 ? 43.20105 -16.63111 17.98296 1.000 7.65769   ? 125 THR A CB   1 
ATOM   1921 O OG1  . THR A 1 128 ? 44.09636 -17.54328 18.64434 1.000 2.38003   ? 125 THR A OG1  1 
ATOM   1922 C CG2  . THR A 1 128 ? 42.95242 -17.10632 16.57564 1.000 10.79149  ? 125 THR A CG2  1 
ATOM   1923 H H    . THR A 1 128 ? 45.71124 -15.47976 17.47977 1.000 5.71929   ? 125 THR A H    1 
ATOM   1924 H HA   . THR A 1 128 ? 43.20136 -14.58852 17.64790 1.000 6.30864   ? 125 THR A HA   1 
ATOM   1925 H HB   . THR A 1 128 ? 42.34971 -16.60648 18.44720 1.000 9.18925   ? 125 THR A HB   1 
ATOM   1926 H HG1  . THR A 1 128 ? 44.02211 -17.46538 19.47742 1.000 2.85605   ? 125 THR A HG1  1 
ATOM   1927 H HG21 . THR A 1 128 ? 42.40495 -17.90696 16.58768 1.000 12.94980  ? 125 THR A HG21 1 
ATOM   1928 H HG22 . THR A 1 128 ? 42.49278 -16.41826 16.06947 1.000 12.94980  ? 125 THR A HG22 1 
ATOM   1929 H HG23 . THR A 1 128 ? 43.79521 -17.30778 16.13974 1.000 12.94980  ? 125 THR A HG23 1 
ATOM   1930 N N    . HIS A 1 129 ? 43.29827 -14.92018 20.31328 1.000 2.82948   ? 126 HIS A N    1 
ATOM   1931 C CA   . HIS A 1 129 ? 43.69099 -15.04076 21.72689 1.000 3.16574   ? 126 HIS A CA   1 
ATOM   1932 C C    . HIS A 1 129 ? 44.48562 -16.33581 21.91105 1.000 3.85963   ? 126 HIS A C    1 
ATOM   1933 O O    . HIS A 1 129 ? 44.18114 -17.34026 21.27704 1.000 6.49751   ? 126 HIS A O    1 
ATOM   1934 C CB   . HIS A 1 129 ? 42.48301 -15.04425 22.67387 1.000 1.38429   ? 126 HIS A CB   1 
ATOM   1935 C CG   . HIS A 1 129 ? 42.86046 -14.79847 24.11601 1.000 2.78535   ? 126 HIS A CG   1 
ATOM   1936 N ND1  . HIS A 1 129 ? 43.29622 -15.78784 24.96203 1.000 9.75446   ? 126 HIS A ND1  1 
ATOM   1937 C CD2  . HIS A 1 129 ? 42.91208 -13.64663 24.83575 1.000 15.64249  ? 126 HIS A CD2  1 
ATOM   1938 C CE1  . HIS A 1 129 ? 43.62276 -15.26258 26.13380 1.000 9.92778   ? 126 HIS A CE1  1 
ATOM   1939 N NE2  . HIS A 1 129 ? 43.36808 -13.96245 26.10593 1.000 7.57454   ? 126 HIS A NE2  1 
ATOM   1940 H H    . HIS A 1 129 ? 42.45729 -14.83145 20.15684 1.000 3.39539   ? 126 HIS A H    1 
ATOM   1941 H HA   . HIS A 1 129 ? 44.23504 -14.27382 21.96500 1.000 3.79891   ? 126 HIS A HA   1 
ATOM   1942 H HB2  . HIS A 1 129 ? 41.86844 -14.34465 22.40228 1.000 1.66117   ? 126 HIS A HB2  1 
ATOM   1943 H HB3  . HIS A 1 129 ? 42.04555 -15.90848 22.62245 1.000 1.66117   ? 126 HIS A HB3  1 
ATOM   1944 H HD2  . HIS A 1 129 ? 42.68257 -12.79861 24.53064 1.000 18.77100  ? 126 HIS A HD2  1 
ATOM   1945 H HE1  . HIS A 1 129 ? 43.97333 -15.72989 26.85741 1.000 11.91336  ? 126 HIS A HE1  1 
ATOM   1946 H HE2  . HIS A 1 129 ? 43.46796 -13.41256 26.75957 1.000 9.08946   ? 126 HIS A HE2  1 
ATOM   1947 N N    . PRO A 1 130 ? 45.48423 -16.36783 22.82871 1.000 6.37335   ? 127 PRO A N    1 
ATOM   1948 C CA   . PRO A 1 130 ? 46.24027 -17.64322 23.04140 1.000 6.39530   ? 127 PRO A CA   1 
ATOM   1949 C C    . PRO A 1 130 ? 45.33115 -18.78434 23.43117 1.000 8.06456   ? 127 PRO A C    1 
ATOM   1950 O O    . PRO A 1 130 ? 45.57063 -19.94170 23.06296 1.000 11.01767  ? 127 PRO A O    1 
ATOM   1951 C CB   . PRO A 1 130 ? 47.24425 -17.31926 24.14183 1.000 10.42063  ? 127 PRO A CB   1 
ATOM   1952 C CG   . PRO A 1 130 ? 47.39525 -15.86395 24.14762 1.000 14.38008  ? 127 PRO A CG   1 
ATOM   1953 C CD   . PRO A 1 130 ? 46.11982 -15.24170 23.52872 1.000 6.45775   ? 127 PRO A CD   1 
ATOM   1954 H HA   . PRO A 1 130 ? 46.74140 -17.86665 22.24150 1.000 7.67437   ? 127 PRO A HA   1 
ATOM   1955 H HB2  . PRO A 1 130 ? 46.90288 -17.63111 24.99455 1.000 12.50477  ? 127 PRO A HB2  1 
ATOM   1956 H HB3  . PRO A 1 130 ? 48.09085 -17.75021 23.94576 1.000 12.50477  ? 127 PRO A HB3  1 
ATOM   1957 H HG2  . PRO A 1 130 ? 47.50599 -15.56008 25.06211 1.000 17.25611  ? 127 PRO A HG2  1 
ATOM   1958 H HG3  . PRO A 1 130 ? 48.17399 -15.62367 23.62157 1.000 17.25611  ? 127 PRO A HG3  1 
ATOM   1959 H HD2  . PRO A 1 130 ? 45.53624 -14.89470 24.22148 1.000 7.74931   ? 127 PRO A HD2  1 
ATOM   1960 H HD3  . PRO A 1 130 ? 46.35034 -14.53570 22.90475 1.000 7.74931   ? 127 PRO A HD3  1 
ATOM   1961 N N    . LEU A 1 131 ? 44.23123 -18.44350 24.10151 1.000 9.90926   ? 128 LEU A N    1 
ATOM   1962 C CA   . LEU A 1 131 ? 43.34653 -19.47811 24.59130 1.000 9.17173   ? 128 LEU A CA   1 
ATOM   1963 C C    . LEU A 1 131 ? 42.47815 -20.04052 23.48019 1.000 12.24817  ? 128 LEU A C    1 
ATOM   1964 O O    . LEU A 1 131 ? 41.85522 -21.07747 23.67097 1.000 11.78888  ? 128 LEU A O    1 
ATOM   1965 C CB   . LEU A 1 131 ? 42.43438 -18.95442 25.72242 1.000 5.96234   ? 128 LEU A CB   1 
ATOM   1966 C CG   . LEU A 1 131 ? 43.13239 -18.76566 27.08191 1.000 18.80636  ? 128 LEU A CG   1 
ATOM   1967 C CD1  . LEU A 1 131 ? 42.17819 -18.18245 28.14622 1.000 21.22069  ? 128 LEU A CD1  1 
ATOM   1968 C CD2  . LEU A 1 131 ? 43.78434 -20.01384 27.63642 1.000 30.44962  ? 128 LEU A CD2  1 
ATOM   1969 H H    . LEU A 1 131 ? 43.98724 -17.63789 24.27776 1.000 11.89112  ? 128 LEU A H    1 
ATOM   1970 H HA   . LEU A 1 131 ? 43.89092 -20.18559 24.97079 1.000 11.00609  ? 128 LEU A HA   1 
ATOM   1971 H HB2  . LEU A 1 131 ? 42.07784 -18.09286 25.45504 1.000 7.15482   ? 128 LEU A HB2  1 
ATOM   1972 H HB3  . LEU A 1 131 ? 41.71078 -19.58748 25.85102 1.000 7.15482   ? 128 LEU A HB3  1 
ATOM   1973 H HG   . LEU A 1 131 ? 43.84610 -18.13427 26.90059 1.000 22.56765  ? 128 LEU A HG   1 
ATOM   1974 H HD11 . LEU A 1 131 ? 42.65731 -18.09309 28.98489 1.000 25.46484  ? 128 LEU A HD11 1 
ATOM   1975 H HD12 . LEU A 1 131 ? 41.86688 -17.31321 27.84888 1.000 25.46484  ? 128 LEU A HD12 1 
ATOM   1976 H HD13 . LEU A 1 131 ? 41.42482 -18.78314 28.25804 1.000 25.46484  ? 128 LEU A HD13 1 
ATOM   1977 H HD21 . LEU A 1 131 ? 44.05105 -19.84961 28.55445 1.000 36.53956  ? 128 LEU A HD21 1 
ATOM   1978 H HD22 . LEU A 1 131 ? 43.14723 -20.74450 27.60272 1.000 36.53956  ? 128 LEU A HD22 1 
ATOM   1979 H HD23 . LEU A 1 131 ? 44.56286 -20.22878 27.09919 1.000 36.53956  ? 128 LEU A HD23 1 
ATOM   1980 N N    . ALA A 1 132 ? 42.42674 -19.35536 22.33878 1.000 4.52148   ? 129 ALA A N    1 
ATOM   1981 C CA   . ALA A 1 132 ? 41.63616 -19.78057 21.20971 1.000 9.48242   ? 129 ALA A CA   1 
ATOM   1982 C C    . ALA A 1 132 ? 42.49273 -20.42490 20.12506 1.000 6.78710   ? 129 ALA A C    1 
ATOM   1983 O O    . ALA A 1 132 ? 41.94749 -20.83163 19.09672 1.000 5.94512   ? 129 ALA A O    1 
ATOM   1984 C CB   . ALA A 1 132 ? 40.87858 -18.57753 20.64031 1.000 3.48150   ? 129 ALA A CB   1 
ATOM   1985 H H    . ALA A 1 132 ? 42.85590 -18.62307 22.20035 1.000 5.42580   ? 129 ALA A H    1 
ATOM   1986 H HA   . ALA A 1 132 ? 40.97898 -20.43472 21.49448 1.000 11.37892  ? 129 ALA A HA   1 
ATOM   1987 H HB1  . ALA A 1 132 ? 40.31960 -18.87526 19.90560 1.000 4.17782   ? 129 ALA A HB1  1 
ATOM   1988 H HB2  . ALA A 1 132 ? 40.32807 -18.19132 21.33936 1.000 4.17782   ? 129 ALA A HB2  1 
ATOM   1989 H HB3  . ALA A 1 132 ? 41.51944 -17.92180 20.32372 1.000 4.17782   ? 129 ALA A HB3  1 
ATOM   1990 N N    . LYS A 1 133 ? 43.78398 -20.59522 20.36573 1.000 4.61472   ? 130 LYS A N    1 
ATOM   1991 C CA   . LYS A 1 133 ? 44.66371 -21.11110 19.32319 1.000 10.40394  ? 130 LYS A CA   1 
ATOM   1992 C C    . LYS A 1 133 ? 44.25186 -22.51813 18.89181 1.000 13.71048  ? 130 LYS A C    1 
ATOM   1993 O O    . LYS A 1 133 ? 44.11478 -22.78189 17.68507 1.000 6.81881   ? 130 LYS A O    1 
ATOM   1994 C CB   . LYS A 1 133 ? 46.10590 -21.06219 19.77528 1.000 10.45336  ? 130 LYS A CB   1 
ATOM   1995 C CG   . LYS A 1 133 ? 47.08825 -21.76220 18.83248 1.000 15.40081  ? 130 LYS A CG   1 
ATOM   1996 C CD   . LYS A 1 133 ? 48.52220 -21.60922 19.32596 1.000 15.28480  ? 130 LYS A CD   1 
ATOM   1997 C CE   . LYS A 1 133 ? 49.50413 -22.14596 18.33257 1.000 28.30242  ? 130 LYS A CE   1 
ATOM   1998 N NZ   . LYS A 1 133 ? 50.15088 -23.34736 18.85699 1.000 20.35257  ? 130 LYS A NZ   1 
ATOM   1999 H H    . LYS A 1 133 ? 44.17351 -20.42306 21.11288 1.000 5.53768   ? 130 LYS A H    1 
ATOM   2000 H HA   . LYS A 1 133 ? 44.59029 -20.53840 18.54375 1.000 12.48474  ? 130 LYS A HA   1 
ATOM   2001 H HB2  . LYS A 1 133 ? 46.37699 -20.13342 19.84461 1.000 12.54405  ? 130 LYS A HB2  1 
ATOM   2002 H HB3  . LYS A 1 133 ? 46.17321 -21.49300 20.64175 1.000 12.54405  ? 130 LYS A HB3  1 
ATOM   2003 H HG2  . LYS A 1 133 ? 46.87742 -22.70807 18.79025 1.000 18.48099  ? 130 LYS A HG2  1 
ATOM   2004 H HG3  . LYS A 1 133 ? 47.02420 -21.36823 17.94840 1.000 18.48099  ? 130 LYS A HG3  1 
ATOM   2005 H HD2  . LYS A 1 133 ? 48.71472 -20.66913 19.46755 1.000 18.34177  ? 130 LYS A HD2  1 
ATOM   2006 H HD3  . LYS A 1 133 ? 48.63017 -22.09872 20.15640 1.000 18.34177  ? 130 LYS A HD3  1 
ATOM   2007 H HE2  . LYS A 1 133 ? 49.04325 -22.37564 17.51053 1.000 33.96292  ? 130 LYS A HE2  1 
ATOM   2008 H HE3  . LYS A 1 133 ? 50.18584 -21.47902 18.15550 1.000 33.96292  ? 130 LYS A HE3  1 
ATOM   2009 H HZ1  . LYS A 1 133 ? 50.73405 -23.66292 18.26333 1.000 24.42310  ? 130 LYS A HZ1  1 
ATOM   2010 H HZ2  . LYS A 1 133 ? 50.58192 -23.15619 19.61181 1.000 24.42310  ? 130 LYS A HZ2  1 
ATOM   2011 H HZ3  . LYS A 1 133 ? 49.54071 -23.97353 19.02345 1.000 24.42310  ? 130 LYS A HZ3  1 
ATOM   2012 N N    . ASP A 1 134 ? 44.09125 -23.44506 19.84310 1.000 8.16880   ? 131 ASP A N    1 
ATOM   2013 C CA   . ASP A 1 134 ? 43.84338 -24.84974 19.48193 1.000 8.88371   ? 131 ASP A CA   1 
ATOM   2014 C C    . ASP A 1 134 ? 42.60777 -24.94869 18.62450 1.000 12.55461  ? 131 ASP A C    1 
ATOM   2015 O O    . ASP A 1 134 ? 42.54679 -25.72395 17.64936 1.000 15.09944  ? 131 ASP A O    1 
ATOM   2016 C CB   . ASP A 1 134 ? 43.71033 -25.69925 20.73896 1.000 21.15702  ? 131 ASP A CB   1 
ATOM   2017 C CG   . ASP A 1 134 ? 45.04068 -25.91117 21.42635 1.000 27.75795  ? 131 ASP A CG   1 
ATOM   2018 O OD1  . ASP A 1 134 ? 46.09049 -25.76460 20.73405 1.000 19.70946  ? 131 ASP A OD1  1 
ATOM   2019 O OD2  . ASP A 1 134 ? 45.01854 -26.19791 22.64655 1.000 33.83736  ? 131 ASP A OD2  1 
ATOM   2020 H H    . ASP A 1 134 ? 44.12013 -23.29273 20.68901 1.000 9.80257   ? 131 ASP A H    1 
ATOM   2021 H HA   . ASP A 1 134 ? 44.59654 -25.19881 18.98014 1.000 10.66047  ? 131 ASP A HA   1 
ATOM   2022 H HB2  . ASP A 1 134 ? 43.11496 -25.25458 21.36242 1.000 25.38844  ? 131 ASP A HB2  1 
ATOM   2023 H HB3  . ASP A 1 134 ? 43.35145 -26.56809 20.49977 1.000 25.38844  ? 131 ASP A HB3  1 
ATOM   2024 N N    . LYS A 1 135 ? 41.61766 -24.12743 18.94684 1.000 11.09285  ? 132 LYS A N    1 
ATOM   2025 C CA   . LYS A 1 135 ? 40.35599 -24.19237 18.22263 1.000 11.12565  ? 132 LYS A CA   1 
ATOM   2026 C C    . LYS A 1 135 ? 40.52388 -23.68863 16.78958 1.000 17.93325  ? 132 LYS A C    1 
ATOM   2027 O O    . LYS A 1 135 ? 39.96437 -24.26765 15.84707 1.000 8.64092   ? 132 LYS A O    1 
ATOM   2028 C CB   . LYS A 1 135 ? 39.28481 -23.37972 18.92911 1.000 24.54013  ? 132 LYS A CB   1 
ATOM   2029 C CG   . LYS A 1 135 ? 37.93684 -23.30601 18.14316 1.000 56.91937  ? 132 LYS A CG   1 
ATOM   2030 C CD   . LYS A 1 135 ? 36.74723 -23.97611 18.90623 1.000 95.42265  ? 132 LYS A CD   1 
ATOM   2031 C CE   . LYS A 1 135 ? 35.38826 -23.87380 18.15284 1.000 101.57419 ? 132 LYS A CE   1 
ATOM   2032 N NZ   . LYS A 1 135 ? 34.20394 -24.23437 19.00486 1.000 97.85223  ? 132 LYS A NZ   1 
ATOM   2033 H H    . LYS A 1 135 ? 41.64877 -23.53427 19.56876 1.000 13.31143  ? 132 LYS A H    1 
ATOM   2034 H HA   . LYS A 1 135 ? 40.06530 -25.11758 18.20291 1.000 13.35080  ? 132 LYS A HA   1 
ATOM   2035 H HB2  . LYS A 1 135 ? 39.10375 -23.78433 19.79191 1.000 29.44817  ? 132 LYS A HB2  1 
ATOM   2036 H HB3  . LYS A 1 135 ? 39.60852 -22.47325 19.04915 1.000 29.44817  ? 132 LYS A HB3  1 
ATOM   2037 H HG2  . LYS A 1 135 ? 37.70911 -22.37503 17.99380 1.000 68.30326  ? 132 LYS A HG2  1 
ATOM   2038 H HG3  . LYS A 1 135 ? 38.04148 -23.76238 17.29364 1.000 68.30326  ? 132 LYS A HG3  1 
ATOM   2039 H HD2  . LYS A 1 135 ? 36.94593 -24.91716 19.03211 1.000 114.50720 ? 132 LYS A HD2  1 
ATOM   2040 H HD3  . LYS A 1 135 ? 36.64218 -23.54120 19.76688 1.000 114.50720 ? 132 LYS A HD3  1 
ATOM   2041 H HE2  . LYS A 1 135 ? 35.26706 -22.96131 17.84695 1.000 121.88905 ? 132 LYS A HE2  1 
ATOM   2042 H HE3  . LYS A 1 135 ? 35.40359 -24.47860 17.39463 1.000 121.88905 ? 132 LYS A HE3  1 
ATOM   2043 H HZ1  . LYS A 1 135 ? 33.45604 -24.17912 18.52558 1.000 117.42270 ? 132 LYS A HZ1  1 
ATOM   2044 H HZ2  . LYS A 1 135 ? 34.29052 -25.06584 19.31026 1.000 117.42270 ? 132 LYS A HZ2  1 
ATOM   2045 H HZ3  . LYS A 1 135 ? 34.14560 -23.67725 19.69646 1.000 117.42270 ? 132 LYS A HZ3  1 
ATOM   2046 N N    . MET A 1 136 ? 41.22602 -22.56520 16.61674 1.000 7.84644   ? 133 MET A N    1 
ATOM   2047 C CA   . MET A 1 136 ? 41.38535 -22.00010 15.26622 1.000 15.32149  ? 133 MET A CA   1 
ATOM   2048 C C    . MET A 1 136 ? 42.20706 -22.92643 14.37053 1.000 12.19156  ? 133 MET A C    1 
ATOM   2049 O O    . MET A 1 136 ? 42.01474 -22.93211 13.15931 1.000 8.82621   ? 133 MET A O    1 
ATOM   2050 C CB   . MET A 1 136 ? 42.02927 -20.60666 15.41283 1.000 6.73756   ? 133 MET A CB   1 
ATOM   2051 C CG   . MET A 1 136 ? 42.42040 -19.81091 14.13634 1.000 8.01290   ? 133 MET A CG   1 
ATOM   2052 S SD   . MET A 1 136 ? 40.74598 -19.21089 13.74361 1.000 7.00497   ? 133 MET A SD   1 
ATOM   2053 C CE   . MET A 1 136 ? 40.96559 -18.32416 12.18637 1.000 8.13705   ? 133 MET A CE   1 
ATOM   2054 H H    . MET A 1 136 ? 41.61091 -22.12017 17.24395 1.000 9.41575   ? 133 MET A H    1 
ATOM   2055 H HA   . MET A 1 136 ? 40.52414 -21.88692 14.83447 1.000 18.38580  ? 133 MET A HA   1 
ATOM   2056 H HB2  . MET A 1 136 ? 41.40396 -20.04812 15.90060 1.000 8.08509   ? 133 MET A HB2  1 
ATOM   2057 H HB3  . MET A 1 136 ? 42.84537 -20.71682 15.92541 1.000 8.08509   ? 133 MET A HB3  1 
ATOM   2058 H HG2  . MET A 1 136 ? 43.03472 -19.08328 14.32088 1.000 9.61549   ? 133 MET A HG2  1 
ATOM   2059 H HG3  . MET A 1 136 ? 42.77853 -20.37777 13.43540 1.000 9.61549   ? 133 MET A HG3  1 
ATOM   2060 H HE1  . MET A 1 136 ? 40.09658 -18.05028 11.85365 1.000 9.76448   ? 133 MET A HE1  1 
ATOM   2061 H HE2  . MET A 1 136 ? 41.52078 -17.54426 12.34264 1.000 9.76448   ? 133 MET A HE2  1 
ATOM   2062 H HE3  . MET A 1 136 ? 41.39466 -18.91263 11.54567 1.000 9.76448   ? 133 MET A HE3  1 
ATOM   2063 N N    . MET A 1 137 ? 43.13830 -23.69561 14.95963 1.000 8.28851   ? 134 MET A N    1 
ATOM   2064 C CA   . MET A 1 137 ? 44.11529 -24.49118 14.21542 1.000 14.22774  ? 134 MET A CA   1 
ATOM   2065 C C    . MET A 1 137 ? 43.65600 -25.91492 13.95408 1.000 8.29016   ? 134 MET A C    1 
ATOM   2066 O O    . MET A 1 137 ? 44.40722 -26.70083 13.37029 1.000 10.78123  ? 134 MET A O    1 
ATOM   2067 C CB   . MET A 1 137 ? 45.44744 -24.55625 14.96350 1.000 9.40338   ? 134 MET A CB   1 
ATOM   2068 C CG   . MET A 1 137 ? 46.19925 -23.23254 14.94025 1.000 6.24505   ? 134 MET A CG   1 
ATOM   2069 S SD   . MET A 1 137 ? 46.56615 -22.65246 13.24893 1.000 9.67161   ? 134 MET A SD   1 
ATOM   2070 C CE   . MET A 1 137 ? 47.65878 -24.01534 12.78112 1.000 15.75822  ? 134 MET A CE   1 
ATOM   2071 H H    . MET A 1 137 ? 43.22212 -23.77153 15.81217 1.000 9.94622   ? 134 MET A H    1 
ATOM   2072 H HA   . MET A 1 137 ? 44.26150 -24.03875 13.36995 1.000 17.07331  ? 134 MET A HA   1 
ATOM   2073 H HB2  . MET A 1 137 ? 45.27858 -24.78991 15.88967 1.000 11.28407  ? 134 MET A HB2  1 
ATOM   2074 H HB3  . MET A 1 137 ? 46.01006 -25.22891 14.54891 1.000 11.28407  ? 134 MET A HB3  1 
ATOM   2075 H HG2  . MET A 1 137 ? 45.65982 -22.55573 15.37826 1.000 7.49408   ? 134 MET A HG2  1 
ATOM   2076 H HG3  . MET A 1 137 ? 47.04163 -23.34000 15.40904 1.000 7.49408   ? 134 MET A HG3  1 
ATOM   2077 H HE1  . MET A 1 137 ? 48.09875 -23.79472 11.94527 1.000 18.90988  ? 134 MET A HE1  1 
ATOM   2078 H HE2  . MET A 1 137 ? 48.31999 -24.14385 13.47911 1.000 18.90988  ? 134 MET A HE2  1 
ATOM   2079 H HE3  . MET A 1 137 ? 47.13004 -24.82146 12.67390 1.000 18.90988  ? 134 MET A HE3  1 
ATOM   2080 N N    . ASN A 1 138 ? 42.45601 -26.25730 14.39408 1.000 12.85627  ? 135 ASN A N    1 
ATOM   2081 C CA   . ASN A 1 138 ? 41.94476 -27.58460 14.13573 1.000 5.49519   ? 135 ASN A CA   1 
ATOM   2082 C C    . ASN A 1 138 ? 41.85146 -27.82970 12.64827 1.000 11.52963  ? 135 ASN A C    1 
ATOM   2083 O O    . ASN A 1 138 ? 41.10796 -27.14290 11.91081 1.000 9.11730   ? 135 ASN A O    1 
ATOM   2084 C CB   . ASN A 1 138 ? 40.59160 -27.75581 14.82642 1.000 18.17066  ? 135 ASN A CB   1 
ATOM   2085 C CG   . ASN A 1 138 ? 40.04958 -29.16637 14.70555 1.000 16.60664  ? 135 ASN A CG   1 
ATOM   2086 O OD1  . ASN A 1 138 ? 40.74962 -30.11140 14.35083 1.000 47.34011  ? 135 ASN A OD1  1 
ATOM   2087 N ND2  . ASN A 1 138 ? 38.78214 -29.29527 14.99924 1.000 50.80959  ? 135 ASN A ND2  1 
ATOM   2088 H H    . ASN A 1 138 ? 41.92760 -25.74438 14.83826 1.000 15.42754  ? 135 ASN A H    1 
ATOM   2089 H HA   . ASN A 1 138 ? 42.54778 -28.25048 14.50162 1.000 6.59424   ? 135 ASN A HA   1 
ATOM   2090 H HB2  . ASN A 1 138 ? 40.68938 -27.55124 15.76955 1.000 21.80481  ? 135 ASN A HB2  1 
ATOM   2091 H HB3  . ASN A 1 138 ? 39.95031 -27.15166 14.42065 1.000 21.80481  ? 135 ASN A HB3  1 
ATOM   2092 H HD21 . ASN A 1 138 ? 38.40637 -30.06744 14.95286 1.000 60.97153  ? 135 ASN A HD21 1 
ATOM   2093 H HD22 . ASN A 1 138 ? 38.32419 -28.60789 15.23881 1.000 60.97153  ? 135 ASN A HD22 1 
ATOM   2094 N N    . GLY A 1 139 ? 42.66342 -28.76159 12.19316 1.000 8.37876   ? 136 GLY A N    1 
ATOM   2095 C CA   . GLY A 1 139 ? 42.73270 -29.08523 10.77432 1.000 6.57959   ? 136 GLY A CA   1 
ATOM   2096 C C    . GLY A 1 139 ? 43.87328 -28.43909 10.03107 1.000 14.89355  ? 136 GLY A C    1 
ATOM   2097 O O    . GLY A 1 139 ? 44.10928 -28.81539 8.87784  1.000 11.33530  ? 136 GLY A O    1 
ATOM   2098 H H    A GLY A 1 139 ? 43.19117 -29.22760 12.68703 0.550 10.05452  ? 136 GLY A H    1 
ATOM   2099 H H    B GLY A 1 139 ? 43.19117 -29.22760 12.68703 0.450 10.05452  ? 136 GLY A H    1 
ATOM   2100 H HA2  . GLY A 1 139 ? 42.82460 -30.04617 10.67918 1.000 7.89553   ? 136 GLY A HA2  1 
ATOM   2101 H HA3  . GLY A 1 139 ? 41.90671 -28.80352 10.35090 1.000 7.89553   ? 136 GLY A HA3  1 
ATOM   2102 N N    . GLY A 1 140 ? 44.56834 -27.46653 10.61285 1.000 7.01618   ? 137 GLY A N    1 
ATOM   2103 C CA   . GLY A 1 140 ? 45.75155 -26.96105 9.93810  1.000 5.87578   ? 137 GLY A CA   1 
ATOM   2104 C C    . GLY A 1 140 ? 45.39077 -26.09261 8.75640  1.000 8.72911   ? 137 GLY A C    1 
ATOM   2105 O O    . GLY A 1 140 ? 46.15788 -26.02220 7.78395  1.000 6.10775   ? 137 GLY A O    1 
ATOM   2106 H H    . GLY A 1 140 ? 44.38132 -27.09887 11.36747 1.000 8.41943   ? 137 GLY A H    1 
ATOM   2107 H HA2  . GLY A 1 140 ? 46.27814 -26.43450 10.55967 1.000 7.05095   ? 137 GLY A HA2  1 
ATOM   2108 H HA3  . GLY A 1 140 ? 46.28693 -27.70587 9.62265  1.000 7.05095   ? 137 GLY A HA3  1 
ATOM   2109 N N    . HIS A 1 141 ? 44.22537 -25.47396 8.78169  1.000 2.15797   ? 138 HIS A N    1 
ATOM   2110 C CA   . HIS A 1 141 ? 43.76191 -24.71051 7.61936  1.000 5.32197   ? 138 HIS A CA   1 
ATOM   2111 C C    . HIS A 1 141 ? 44.33462 -23.32049 7.54997  1.000 10.41007  ? 138 HIS A C    1 
ATOM   2112 O O    . HIS A 1 141 ? 44.17910 -22.64769 6.51383  1.000 10.12721  ? 138 HIS A O    1 
ATOM   2113 C CB   . HIS A 1 141 ? 42.24576 -24.58166 7.64494  1.000 6.49644   ? 138 HIS A CB   1 
ATOM   2114 C CG   . HIS A 1 141 ? 41.54150 -25.88571 7.47039  1.000 8.90845   ? 138 HIS A CG   1 
ATOM   2115 N ND1  . HIS A 1 141 ? 41.64234 -26.62013 6.30348  1.000 10.36742  ? 138 HIS A ND1  1 
ATOM   2116 C CD2  . HIS A 1 141 ? 40.71046 -26.56769 8.28454  1.000 12.09525  ? 138 HIS A CD2  1 
ATOM   2117 C CE1  . HIS A 1 141 ? 40.91543 -27.71206 6.42869  1.000 10.96992  ? 138 HIS A CE1  1 
ATOM   2118 N NE2  . HIS A 1 141 ? 40.36021 -27.70613 7.63184  1.000 12.85910  ? 138 HIS A NE2  1 
ATOM   2119 H H    . HIS A 1 141 ? 43.68305 -25.47545 9.44914  1.000 2.58958   ? 138 HIS A H    1 
ATOM   2120 H HA   . HIS A 1 141 ? 44.03264 -25.19902 6.82629  1.000 6.38638   ? 138 HIS A HA   1 
ATOM   2121 H HB2  . HIS A 1 141 ? 41.97667 -24.20926 8.49923  1.000 7.79574   ? 138 HIS A HB2  1 
ATOM   2122 H HB3  . HIS A 1 141 ? 41.96840 -23.99405 6.92474  1.000 7.79574   ? 138 HIS A HB3  1 
ATOM   2123 H HD2  . HIS A 1 141 ? 40.43024 -26.30772 9.13235  1.000 14.51432  ? 138 HIS A HD2  1 
ATOM   2124 H HE1  . HIS A 1 141 ? 40.81015 -28.37340 5.78337  1.000 13.16392  ? 138 HIS A HE1  1 
ATOM   2125 H HE2  . HIS A 1 141 ? 39.85657 -28.32646 7.94987  0.335 15.43094  ? 138 HIS A HE2  1 
ATOM   2126 N N    . TYR A 1 142 ? 44.89664 -22.80717 8.65069  1.000 2.74219   ? 139 TYR A N    1 
ATOM   2127 C CA   . TYR A 1 142 ? 45.54259 -21.51309 8.67980  1.000 6.54834   ? 139 TYR A CA   1 
ATOM   2128 C C    . TYR A 1 142 ? 46.95168 -21.68886 9.23486  1.000 2.82061   ? 139 TYR A C    1 
ATOM   2129 O O    . TYR A 1 142 ? 47.27930 -22.69214 9.83972  1.000 9.40784   ? 139 TYR A O    1 
ATOM   2130 C CB   . TYR A 1 142 ? 44.80845 -20.50495 9.59959  1.000 4.50908   ? 139 TYR A CB   1 
ATOM   2131 C CG   . TYR A 1 142 ? 43.31649 -20.33143 9.30652  1.000 4.92867   ? 139 TYR A CG   1 
ATOM   2132 C CD1  . TYR A 1 142 ? 42.85555 -19.34879 8.40518  1.000 2.37170   ? 139 TYR A CD1  1 
ATOM   2133 C CD2  . TYR A 1 142 ? 42.38555 -21.12683 9.91416  1.000 6.88801   ? 139 TYR A CD2  1 
ATOM   2134 C CE1  . TYR A 1 142 ? 41.48157 -19.20147 8.13607  1.000 9.11915   ? 139 TYR A CE1  1 
ATOM   2135 C CE2  . TYR A 1 142 ? 41.03317 -20.95051 9.67593  1.000 7.46168   ? 139 TYR A CE2  1 
ATOM   2136 C CZ   . TYR A 1 142 ? 40.58613 -20.00070 8.77706  1.000 7.42785   ? 139 TYR A CZ   1 
ATOM   2137 O OH   . TYR A 1 142 ? 39.23354 -19.91552 8.58441  1.000 11.54262  ? 139 TYR A OH   1 
ATOM   2138 H H    A TYR A 1 142 ? 44.91103 -23.21054 9.41009  0.530 3.29065   ? 139 TYR A H    1 
ATOM   2139 H H    B TYR A 1 142 ? 44.91103 -23.21054 9.41009  0.470 3.29065   ? 139 TYR A H    1 
ATOM   2140 H HA   . TYR A 1 142 ? 45.56110 -21.16515 7.77454  1.000 7.85803   ? 139 TYR A HA   1 
ATOM   2141 H HB2  . TYR A 1 142 ? 44.89129 -20.80935 10.51686 1.000 5.41091   ? 139 TYR A HB2  1 
ATOM   2142 H HB3  . TYR A 1 142 ? 45.22765 -19.63598 9.49927  1.000 5.41091   ? 139 TYR A HB3  1 
ATOM   2143 H HD1  . TYR A 1 142 ? 43.46790 -18.79057 7.98291  1.000 2.84605   ? 139 TYR A HD1  1 
ATOM   2144 H HD2  . TYR A 1 142 ? 42.66475 -21.79630 10.49618 1.000 8.26563   ? 139 TYR A HD2  1 
ATOM   2145 H HE1  . TYR A 1 142 ? 41.18863 -18.56376 7.52580  1.000 10.94300  ? 139 TYR A HE1  1 
ATOM   2146 H HE2  . TYR A 1 142 ? 40.41597 -21.47944 10.12781 1.000 8.95403   ? 139 TYR A HE2  1 
ATOM   2147 H HH   . TYR A 1 142 ? 39.05828 -19.29250 8.04895  1.000 13.85116  ? 139 TYR A HH   1 
ATOM   2148 N N    . THR A 1 143 ? 47.76166 -20.63530 9.07004  1.000 5.91804   ? 140 THR A N    1 
ATOM   2149 C CA   . THR A 1 143 ? 49.04610 -20.52649 9.72068  1.000 8.12109   ? 140 THR A CA   1 
ATOM   2150 C C    . THR A 1 143 ? 48.97003 -19.52512 10.88290 1.000 12.90159  ? 140 THR A C    1 
ATOM   2151 O O    . THR A 1 143 ? 48.47541 -18.40812 10.72208 1.000 9.59743   ? 140 THR A O    1 
ATOM   2152 C CB   . THR A 1 143 ? 50.09436 -20.12779 8.69212  1.000 12.67406  ? 140 THR A CB   1 
ATOM   2153 O OG1  . THR A 1 143 ? 50.19260 -21.21279 7.76673  1.000 14.12687  ? 140 THR A OG1  1 
ATOM   2154 C CG2  . THR A 1 143 ? 51.47748 -19.93267 9.28220  1.000 11.35163  ? 140 THR A CG2  1 
ATOM   2155 H H    . THR A 1 143 ? 47.57235 -19.96095 8.57102  1.000 7.10167   ? 140 THR A H    1 
ATOM   2156 H HA   . THR A 1 143 ? 49.30536 -21.37347 10.11604 1.000 9.74532   ? 140 THR A HA   1 
ATOM   2157 H HB   . THR A 1 143 ? 49.83053 -19.28512 8.29063  1.000 15.20889  ? 140 THR A HB   1 
ATOM   2158 H HG1  . THR A 1 143 ? 50.75955 -21.03383 7.17331  1.000 16.95226  ? 140 THR A HG1  1 
ATOM   2159 H HG21 . THR A 1 143 ? 52.12930 -19.82643 8.57175  1.000 13.62197  ? 140 THR A HG21 1 
ATOM   2160 H HG22 . THR A 1 143 ? 51.49051 -19.14087 9.84236  1.000 13.62197  ? 140 THR A HG22 1 
ATOM   2161 H HG23 . THR A 1 143 ? 51.72047 -20.70264 9.81979  1.000 13.62197  ? 140 THR A HG23 1 
ATOM   2162 N N    . TYR A 1 144 ? 49.48937 -19.92838 12.03259 1.000 6.52990   ? 141 TYR A N    1 
ATOM   2163 C CA   . TYR A 1 144 ? 49.32441 -19.14202 13.25162 1.000 8.41319   ? 141 TYR A CA   1 
ATOM   2164 C C    . TYR A 1 144 ? 50.45359 -18.14588 13.44356 1.000 7.42824   ? 141 TYR A C    1 
ATOM   2165 O O    . TYR A 1 144 ? 51.61805 -18.45648 13.22972 1.000 14.80777  ? 141 TYR A O    1 
ATOM   2166 C CB   . TYR A 1 144 ? 49.21658 -20.07134 14.46950 1.000 4.45308   ? 141 TYR A CB   1 
ATOM   2167 C CG   . TYR A 1 144 ? 48.59576 -19.38971 15.68547 1.000 6.59402   ? 141 TYR A CG   1 
ATOM   2168 C CD1  . TYR A 1 144 ? 47.21982 -19.14801 15.73063 1.000 8.62736   ? 141 TYR A CD1  1 
ATOM   2169 C CD2  . TYR A 1 144 ? 49.36925 -18.98909 16.75191 1.000 11.52782  ? 141 TYR A CD2  1 
ATOM   2170 C CE1  . TYR A 1 144 ? 46.63345 -18.54069 16.81409 1.000 9.60349   ? 141 TYR A CE1  1 
ATOM   2171 C CE2  . TYR A 1 144 ? 48.79478 -18.34248 17.82653 1.000 11.92223  ? 141 TYR A CE2  1 
ATOM   2172 C CZ   . TYR A 1 144 ? 47.43125 -18.13466 17.84740 1.000 7.56050   ? 141 TYR A CZ   1 
ATOM   2173 O OH   . TYR A 1 144 ? 46.83578 -17.53650 18.91592 1.000 6.08267   ? 141 TYR A OH   1 
ATOM   2174 H H    . TYR A 1 144 ? 49.94152 -20.65267 12.13542 1.000 7.83589   ? 141 TYR A H    1 
ATOM   2175 H HA   . TYR A 1 144 ? 48.50772 -18.62369 13.17904 1.000 10.09585  ? 141 TYR A HA   1 
ATOM   2176 H HB2  . TYR A 1 144 ? 48.66167 -20.83218 14.23690 1.000 5.34371   ? 141 TYR A HB2  1 
ATOM   2177 H HB3  . TYR A 1 144 ? 50.10531 -20.37190 14.71593 1.000 5.34371   ? 141 TYR A HB3  1 
ATOM   2178 H HD1  . TYR A 1 144 ? 46.68944 -19.40416 15.01091 1.000 10.35285  ? 141 TYR A HD1  1 
ATOM   2179 H HD2  . TYR A 1 144 ? 50.28424 -19.15541 16.74767 1.000 13.83340  ? 141 TYR A HD2  1 
ATOM   2180 H HE1  . TYR A 1 144 ? 45.71338 -18.40850 16.84414 1.000 11.52420  ? 141 TYR A HE1  1 
ATOM   2181 H HE2  . TYR A 1 144 ? 49.32362 -18.04840 18.53275 1.000 14.30669  ? 141 TYR A HE2  1 
ATOM   2182 H HH   . TYR A 1 144 ? 46.00610 -17.48952 18.79336 1.000 7.29922   ? 141 TYR A HH   1 
ATOM   2183 N N    A SER A 1 145 ? 50.09398 -16.95191 13.86766 0.787 10.28138  ? 142 SER A N    1 
ATOM   2184 N N    B SER A 1 145 ? 50.08853 -16.94284 13.87460 0.213 10.16764  ? 142 SER A N    1 
ATOM   2185 C CA   A SER A 1 145 ? 51.04692 -15.89734 14.14690 0.787 5.99260   ? 142 SER A CA   1 
ATOM   2186 C CA   B SER A 1 145 ? 51.05427 -15.90073 14.16517 0.213 6.21297   ? 142 SER A CA   1 
ATOM   2187 C C    A SER A 1 145 ? 50.81844 -15.45901 15.57389 0.787 8.39077   ? 142 SER A C    1 
ATOM   2188 C C    B SER A 1 145 ? 50.81302 -15.43768 15.58072 0.213 8.39049   ? 142 SER A C    1 
ATOM   2189 O O    A SER A 1 145 ? 49.66500 -15.42957 16.03230 0.787 7.15723   ? 142 SER A O    1 
ATOM   2190 O O    B SER A 1 145 ? 49.67522 -15.40726 16.05096 0.213 7.27779   ? 142 SER A O    1 
ATOM   2191 C CB   A SER A 1 145 ? 50.83899 -14.70241 13.25797 0.787 11.64031  ? 142 SER A CB   1 
ATOM   2192 C CB   B SER A 1 145 ? 50.91206 -14.74784 13.18939 0.213 11.50266  ? 142 SER A CB   1 
ATOM   2193 O OG   A SER A 1 145 ? 51.53230 -13.62356 13.82872 0.787 8.27199   ? 142 SER A OG   1 
ATOM   2194 O OG   B SER A 1 145 ? 49.62610 -14.17831 13.32708 0.213 8.74401   ? 142 SER A OG   1 
ATOM   2195 H H    A SER A 1 145 ? 49.27742 -16.72021 14.00600 0.787 12.33767  ? 142 SER A H    1 
ATOM   2196 H H    B SER A 1 145 ? 49.27280 -16.70526 14.00775 0.213 12.20118  ? 142 SER A H    1 
ATOM   2197 H HA   A SER A 1 145 ? 51.95192 -16.21954 14.01254 0.787 7.19114   ? 142 SER A HA   1 
ATOM   2198 H HA   B SER A 1 145 ? 51.96343 -16.22570 14.07180 0.213 7.45557   ? 142 SER A HA   1 
ATOM   2199 H HB2  A SER A 1 145 ? 51.18929 -14.88664 12.37239 0.787 13.96838  ? 142 SER A HB2  1 
ATOM   2200 H HB2  B SER A 1 145 ? 51.58446 -14.07628 13.38378 0.213 13.80320  ? 142 SER A HB2  1 
ATOM   2201 H HB3  A SER A 1 145 ? 49.89327 -14.49364 13.20384 0.787 13.96838  ? 142 SER A HB3  1 
ATOM   2202 H HB3  B SER A 1 145 ? 51.02365 -15.07659 12.28365 0.213 13.80320  ? 142 SER A HB3  1 
ATOM   2203 H HG   A SER A 1 145 ? 51.44203 -12.93882 13.35061 0.787 9.92640   ? 142 SER A HG   1 
ATOM   2204 H HG   B SER A 1 145 ? 49.58090 -13.74049 14.04252 0.213 10.49283  ? 142 SER A HG   1 
ATOM   2205 N N    . GLU A 1 146 ? 51.89945 -15.09426 16.26488 1.000 6.38683   ? 143 GLU A N    1 
ATOM   2206 C CA   A GLU A 1 146 ? 51.79585 -14.50830 17.58999 0.467 11.08064  ? 143 GLU A CA   1 
ATOM   2207 C CA   C GLU A 1 146 ? 51.74334 -14.50725 17.58335 0.533 11.08323  ? 143 GLU A CA   1 
ATOM   2208 C C    . GLU A 1 146 ? 51.92132 -12.99282 17.55138 1.000 10.18097  ? 143 GLU A C    1 
ATOM   2209 O O    . GLU A 1 146 ? 52.02968 -12.35939 18.61108 1.000 12.39845  ? 143 GLU A O    1 
ATOM   2210 C CB   A GLU A 1 146 ? 52.86570 -15.09200 18.52692 0.467 14.17833  ? 143 GLU A CB   1 
ATOM   2211 C CB   C GLU A 1 146 ? 52.75180 -15.11694 18.57061 0.533 14.20416  ? 143 GLU A CB   1 
ATOM   2212 C CG   A GLU A 1 146 ? 52.78382 -16.61579 18.77258 0.467 18.69545  ? 143 GLU A CG   1 
ATOM   2213 C CG   C GLU A 1 146 ? 52.55866 -16.60261 18.83351 0.533 18.38818  ? 143 GLU A CG   1 
ATOM   2214 C CD   A GLU A 1 146 ? 52.29228 -17.04713 20.19024 0.467 12.61609  ? 143 GLU A CD   1 
ATOM   2215 C CD   C GLU A 1 146 ? 53.66068 -17.22674 19.68024 0.533 15.79233  ? 143 GLU A CD   1 
ATOM   2216 O OE1  A GLU A 1 146 ? 52.12263 -16.20803 21.11103 0.467 26.30704  ? 143 GLU A OE1  1 
ATOM   2217 O OE1  C GLU A 1 146 ? 54.25682 -16.53528 20.53276 0.533 19.67267  ? 143 GLU A OE1  1 
ATOM   2218 O OE2  A GLU A 1 146 ? 52.06842 -18.25878 20.39410 0.467 14.71670  ? 143 GLU A OE2  1 
ATOM   2219 O OE2  C GLU A 1 146 ? 53.91493 -18.43337 19.50691 0.533 23.53701  ? 143 GLU A OE2  1 
ATOM   2220 H H    A GLU A 1 146 ? 52.70657 -15.17914 15.98035 0.787 7.66421   ? 143 GLU A H    1 
ATOM   2221 H HA   A GLU A 1 146 ? 50.92905 -14.73804 17.95983 0.467 13.29679  ? 143 GLU A HA   1 
ATOM   2222 H HA   C GLU A 1 146 ? 50.84535 -14.69964 17.89563 0.533 13.29989  ? 143 GLU A HA   1 
ATOM   2223 H HB2  A GLU A 1 146 ? 53.73789 -14.90886 18.14397 0.467 17.01401  ? 143 GLU A HB2  1 
ATOM   2224 H HB2  C GLU A 1 146 ? 53.64542 -14.99655 18.21305 0.533 17.04500  ? 143 GLU A HB2  1 
ATOM   2225 H HB3  A GLU A 1 146 ? 52.78427 -14.65674 19.38994 0.467 17.01401  ? 143 GLU A HB3  1 
ATOM   2226 H HB3  C GLU A 1 146 ? 52.66952 -14.65607 19.42016 0.533 17.04500  ? 143 GLU A HB3  1 
ATOM   2227 H HG2  A GLU A 1 146 ? 52.16787 -16.99595 18.12684 0.467 22.43456  ? 143 GLU A HG2  1 
ATOM   2228 H HG2  C GLU A 1 146 ? 51.71869 -16.72989 19.30165 0.533 22.06584  ? 143 GLU A HG2  1 
ATOM   2229 H HG3  A GLU A 1 146 ? 53.66900 -16.99252 18.64837 0.467 22.43456  ? 143 GLU A HG3  1 
ATOM   2230 H HG3  C GLU A 1 146 ? 52.53890 -17.06975 17.98363 0.533 22.06584  ? 143 GLU A HG3  1 
ATOM   2231 N N    . ASN A 1 147 ? 51.94539 -12.38617 16.35902 1.000 12.52731  ? 144 ASN A N    1 
ATOM   2232 C CA   . ASN A 1 147 ? 51.93392 -10.91926 16.27994 1.000 3.76405   ? 144 ASN A CA   1 
ATOM   2233 C C    . ASN A 1 147 ? 50.63101 -10.39126 16.90191 1.000 15.24415  ? 144 ASN A C    1 
ATOM   2234 O O    . ASN A 1 147 ? 49.58067 -11.02786 16.83675 1.000 11.10415  ? 144 ASN A O    1 
ATOM   2235 C CB   . ASN A 1 147 ? 51.99895 -10.43916 14.84898 1.000 8.94882   ? 144 ASN A CB   1 
ATOM   2236 C CG   . ASN A 1 147 ? 53.37433 -10.42354 14.32018 1.000 21.17607  ? 144 ASN A CG   1 
ATOM   2237 O OD1  . ASN A 1 147 ? 54.34974 -10.46683 15.05856 1.000 15.22590  ? 144 ASN A OD1  1 
ATOM   2238 N ND2  . ASN A 1 147 ? 53.46457 -10.26179 13.03305 1.000 35.83379  ? 144 ASN A ND2  1 
ATOM   2239 H H    . ASN A 1 147 ? 51.96794 -12.78962 15.59987 1.000 15.03279  ? 144 ASN A H    1 
ATOM   2240 H HA   . ASN A 1 147 ? 52.70852 -10.57386 16.75068 1.000 4.51687   ? 144 ASN A HA   1 
ATOM   2241 H HB2  . ASN A 1 147 ? 51.46916 -11.03065 14.29188 1.000 10.73861  ? 144 ASN A HB2  1 
ATOM   2242 H HB3  . ASN A 1 147 ? 51.64810 -9.53608  14.80144 1.000 10.73861  ? 144 ASN A HB3  1 
ATOM   2243 H HD21 . ASN A 1 147 ? 54.23687 -10.24264 12.65518 1.000 43.00056  ? 144 ASN A HD21 1 
ATOM   2244 H HD22 . ASN A 1 147 ? 52.75196 -10.17398 12.55970 1.000 43.00056  ? 144 ASN A HD22 1 
ATOM   2245 N N    . ARG A 1 148 ? 50.68290 -9.21326  17.46881 1.000 3.44465   ? 145 ARG A N    1 
ATOM   2246 C CA   . ARG A 1 148 ? 49.49418 -8.66679  18.16120 1.000 6.32399   ? 145 ARG A CA   1 
ATOM   2247 C C    . ARG A 1 148 ? 48.37447 -8.30275  17.19077 1.000 3.39290   ? 145 ARG A C    1 
ATOM   2248 O O    . ARG A 1 148 ? 47.17029 -8.37910  17.52731 1.000 4.96860   ? 145 ARG A O    1 
ATOM   2249 C CB   . ARG A 1 148 ? 49.91549 -7.43884  18.94418 1.000 12.52954  ? 145 ARG A CB   1 
ATOM   2250 C CG   . ARG A 1 148 ? 50.91066 -7.67985  20.11079 1.000 17.81404  ? 145 ARG A CG   1 
ATOM   2251 C CD   . ARG A 1 148 ? 51.46267 -6.37635  20.84825 1.000 26.32398  ? 145 ARG A CD   1 
ATOM   2252 N NE   . ARG A 1 148 ? 50.45081 -5.49704  21.46286 1.000 17.23914  ? 145 ARG A NE   1 
ATOM   2253 C CZ   . ARG A 1 148 ? 49.76376 -5.72438  22.59018 1.000 25.68862  ? 145 ARG A CZ   1 
ATOM   2254 N NH1  . ARG A 1 148 ? 49.96516 -6.80626  23.34009 1.000 27.80500  ? 145 ARG A NH1  1 
ATOM   2255 N NH2  . ARG A 1 148 ? 48.83476 -4.84512  22.96954 1.000 22.07866  ? 145 ARG A NH2  1 
ATOM   2256 H H    . ARG A 1 148 ? 51.37313 -8.70036  17.47925 1.000 4.13360   ? 145 ARG A H    1 
ATOM   2257 H HA   . ARG A 1 148 ? 49.14506 -9.34158  18.76426 1.000 7.58881   ? 145 ARG A HA   1 
ATOM   2258 H HB2  . ARG A 1 148 ? 50.33953 -6.81924  18.33003 1.000 15.03546  ? 145 ARG A HB2  1 
ATOM   2259 H HB3  . ARG A 1 148 ? 49.11998 -7.03567  19.32566 1.000 15.03546  ? 145 ARG A HB3  1 
ATOM   2260 H HG2  . ARG A 1 148 ? 50.46522 -8.21961  20.78246 1.000 21.37686  ? 145 ARG A HG2  1 
ATOM   2261 H HG3  . ARG A 1 148 ? 51.67978 -8.15530  19.75966 1.000 21.37686  ? 145 ARG A HG3  1 
ATOM   2262 H HD2  . ARG A 1 148 ? 52.06150 -6.65998  21.55667 1.000 31.58880  ? 145 ARG A HD2  1 
ATOM   2263 H HD3  . ARG A 1 148 ? 51.94658 -5.84292  20.19850 1.000 31.58880  ? 145 ARG A HD3  1 
ATOM   2264 H HE   . ARG A 1 148 ? 50.28390 -4.75924  21.05371 1.000 20.68698  ? 145 ARG A HE   1 
ATOM   2265 H HH11 . ARG A 1 148 ? 50.55321 -7.38844  23.10586 1.000 33.36602  ? 145 ARG A HH11 1 
ATOM   2266 H HH12 . ARG A 1 148 ? 49.50717 -6.92276  24.05861 1.000 33.36602  ? 145 ARG A HH12 1 
ATOM   2267 H HH21 . ARG A 1 148 ? 48.68474 -4.14537  22.49262 1.000 26.49441  ? 145 ARG A HH21 1 
ATOM   2268 H HH22 . ARG A 1 148 ? 48.38595 -4.97810  23.69098 1.000 26.49441  ? 145 ARG A HH22 1 
ATOM   2269 N N    . VAL A 1 149 ? 48.76162 -7.82991  16.00755 1.000 3.93236   ? 146 VAL A N    1 
ATOM   2270 C CA   . VAL A 1 149 ? 47.87746 -7.63002  14.87822 1.000 7.23171   ? 146 VAL A CA   1 
ATOM   2271 C C    . VAL A 1 149 ? 48.53504 -8.33674  13.68797 1.000 6.76978   ? 146 VAL A C    1 
ATOM   2272 O O    . VAL A 1 149 ? 49.74557 -8.20335  13.47784 1.000 9.60755   ? 146 VAL A O    1 
ATOM   2273 C CB   . VAL A 1 149 ? 47.69571 -6.13170  14.56894 1.000 7.55265   ? 146 VAL A CB   1 
ATOM   2274 C CG1  . VAL A 1 149 ? 46.78040 -5.99430  13.44404 1.000 10.34586  ? 146 VAL A CG1  1 
ATOM   2275 C CG2  . VAL A 1 149 ? 47.07989 -5.29747  15.71383 1.000 15.42226  ? 146 VAL A CG2  1 
ATOM   2276 H H    . VAL A 1 149 ? 49.57413 -7.60866  15.83297 1.000 4.71885   ? 146 VAL A H    1 
ATOM   2277 H HA   . VAL A 1 149 ? 47.00383 -8.01455  15.05089 1.000 8.67807   ? 146 VAL A HA   1 
ATOM   2278 H HB   . VAL A 1 149 ? 48.58882 -5.79268  14.40068 1.000 9.06320   ? 146 VAL A HB   1 
ATOM   2279 H HG11 . VAL A 1 149 ? 46.54090 -5.05966  13.34412 1.000 12.41505  ? 146 VAL A HG11 1 
ATOM   2280 H HG12 . VAL A 1 149 ? 47.21939 -6.31115  12.63918 1.000 12.41505  ? 146 VAL A HG12 1 
ATOM   2281 H HG13 . VAL A 1 149 ? 45.98562 -6.52273  13.61723 1.000 12.41505  ? 146 VAL A HG13 1 
ATOM   2282 H HG21 . VAL A 1 149 ? 47.01996 -4.37106  15.43263 1.000 18.50673  ? 146 VAL A HG21 1 
ATOM   2283 H HG22 . VAL A 1 149 ? 46.19481 -5.64040  15.91370 1.000 18.50673  ? 146 VAL A HG22 1 
ATOM   2284 H HG23 . VAL A 1 149 ? 47.64717 -5.36929  16.49736 1.000 18.50673  ? 146 VAL A HG23 1 
ATOM   2285 N N    . GLU A 1 150 ? 47.73864 -9.06944  12.92529 1.000 9.70297   ? 147 GLU A N    1 
ATOM   2286 C CA   . GLU A 1 150 ? 48.18209 -9.86776  11.80894 1.000 5.60884   ? 147 GLU A CA   1 
ATOM   2287 C C    . GLU A 1 150 ? 47.27615 -9.54971  10.62229 1.000 8.17145   ? 147 GLU A C    1 
ATOM   2288 O O    . GLU A 1 150 ? 46.06171 -9.45200  10.77343 1.000 7.43606   ? 147 GLU A O    1 
ATOM   2289 C CB   . GLU A 1 150 ? 48.14459 -11.39979 12.09317 1.000 10.31759  ? 147 GLU A CB   1 
ATOM   2290 C CG   . GLU A 1 150 ? 48.92963 -12.19352 10.98601 1.000 14.01955  ? 147 GLU A CG   1 
ATOM   2291 C CD   . GLU A 1 150 ? 50.41695 -11.75657 10.86820 1.000 10.99055  ? 147 GLU A CD   1 
ATOM   2292 O OE1  . GLU A 1 150 ? 51.20089 -11.97000 11.82950 1.000 14.46827  ? 147 GLU A OE1  1 
ATOM   2293 O OE2  . GLU A 1 150 ? 50.77511 -11.10554 9.86270  1.000 17.97100  ? 147 GLU A OE2  1 
ATOM   2294 H H    . GLU A 1 150 ? 46.88867 -9.11951  13.04633 1.000 11.64358  ? 147 GLU A H    1 
ATOM   2295 H HA   . GLU A 1 150 ? 49.10384 -9.64630  11.60347 1.000 6.73063   ? 147 GLU A HA   1 
ATOM   2296 H HB2  . GLU A 1 150 ? 48.55739 -11.57909 12.95244 1.000 12.38113  ? 147 GLU A HB2  1 
ATOM   2297 H HB3  . GLU A 1 150 ? 47.22390 -11.70510 12.09726 1.000 12.38113  ? 147 GLU A HB3  1 
ATOM   2298 H HG2  . GLU A 1 150 ? 48.91164 -13.13881 11.20284 1.000 16.82347  ? 147 GLU A HG2  1 
ATOM   2299 H HG3  . GLU A 1 150 ? 48.50421 -12.04191 10.12756 1.000 16.82347  ? 147 GLU A HG3  1 
ATOM   2300 N N    . LYS A 1 151 ? 47.87637 -9.36911  9.45168  1.000 14.00086  ? 148 LYS A N    1 
ATOM   2301 C CA   . LYS A 1 151 ? 47.08248 -9.08400  8.25131  1.000 21.04258  ? 148 LYS A CA   1 
ATOM   2302 C C    . LYS A 1 151 ? 47.65828 -9.84951  7.08249  1.000 9.13476   ? 148 LYS A C    1 
ATOM   2303 O O    . LYS A 1 151 ? 48.86770 -9.85312  6.85591  1.000 21.67455  ? 148 LYS A O    1 
ATOM   2304 C CB   . LYS A 1 151 ? 47.01646 -7.58084  7.94115  1.000 18.37502  ? 148 LYS A CB   1 
ATOM   2305 C CG   . LYS A 1 151 ? 46.07285 -7.17315  6.73145  1.000 19.90285  ? 148 LYS A CG   1 
ATOM   2306 C CD   . LYS A 1 151 ? 46.16671 -5.63130  6.44955  1.000 16.94325  ? 148 LYS A CD   1 
ATOM   2307 C CE   . LYS A 1 151 ? 45.32101 -5.25439  5.22305  1.000 35.05632  ? 148 LYS A CE   1 
ATOM   2308 N NZ   . LYS A 1 151 ? 45.64287 -6.10381  3.96223  1.000 54.44659  ? 148 LYS A NZ   1 
ATOM   2309 H H    A LYS A 1 151 ? 48.72619 -9.40517  9.32478  0.340 16.80105  ? 148 LYS A H    1 
ATOM   2310 H H    B LYS A 1 151 ? 48.72619 -9.40517  9.32478  0.660 16.80105  ? 148 LYS A H    1 
ATOM   2311 H HA   . LYS A 1 151 ? 46.17571 -9.39433  8.40087  1.000 25.25111  ? 148 LYS A HA   1 
ATOM   2312 H HB2  . LYS A 1 151 ? 46.68948 -7.12075  8.73001  1.000 22.05004  ? 148 LYS A HB2  1 
ATOM   2313 H HB3  . LYS A 1 151 ? 47.91111 -7.27440  7.72531  1.000 22.05004  ? 148 LYS A HB3  1 
ATOM   2314 H HG2  . LYS A 1 151 ? 46.34606 -7.64983  5.93205  1.000 23.88344  ? 148 LYS A HG2  1 
ATOM   2315 H HG3  . LYS A 1 151 ? 45.15321 -7.39115  6.94970  1.000 23.88344  ? 148 LYS A HG3  1 
ATOM   2316 H HD2  . LYS A 1 151 ? 45.83402 -5.13991  7.21685  1.000 20.33191  ? 148 LYS A HD2  1 
ATOM   2317 H HD3  . LYS A 1 151 ? 47.08945 -5.38858  6.27479  1.000 20.33191  ? 148 LYS A HD3  1 
ATOM   2318 H HE2  . LYS A 1 151 ? 44.38383 -5.38454  5.43674  1.000 42.06760  ? 148 LYS A HE2  1 
ATOM   2319 H HE3  . LYS A 1 151 ? 45.48507 -4.32395  5.00334  1.000 42.06760  ? 148 LYS A HE3  1 
ATOM   2320 H HZ1  . LYS A 1 151 ? 45.14557 -5.83109  3.27637  1.000 65.33592  ? 148 LYS A HZ1  1 
ATOM   2321 H HZ2  . LYS A 1 151 ? 46.50241 -6.01729  3.74820  1.000 65.33592  ? 148 LYS A HZ2  1 
ATOM   2322 H HZ3  . LYS A 1 151 ? 45.46979 -6.96223  4.12120  1.000 65.33592  ? 148 LYS A HZ3  1 
ATOM   2323 N N    . ASP A 1 152 ? 46.81448 -10.61375 6.44533  1.000 15.50211  ? 149 ASP A N    1 
ATOM   2324 C CA   . ASP A 1 152 ? 47.28323 -11.43022 5.35153  1.000 11.13410  ? 149 ASP A CA   1 
ATOM   2325 C C    . ASP A 1 152 ? 46.18751 -11.33759 4.32162  1.000 21.21710  ? 149 ASP A C    1 
ATOM   2326 O O    . ASP A 1 152 ? 45.07365 -11.82231 4.55196  1.000 17.46600  ? 149 ASP A O    1 
ATOM   2327 C CB   . ASP A 1 152 ? 47.55515 -12.85621 5.73958  1.000 8.26805   ? 149 ASP A CB   1 
ATOM   2328 C CG   . ASP A 1 152 ? 48.32908 -13.62015 4.69070  1.000 19.52376  ? 149 ASP A CG   1 
ATOM   2329 O OD1  . ASP A 1 152 ? 48.93161 -13.05789 3.73090  1.000 18.79966  ? 149 ASP A OD1  1 
ATOM   2330 O OD2  . ASP A 1 152 ? 48.33602 -14.84762 4.89556  1.000 10.26374  ? 149 ASP A OD2  1 
ATOM   2331 H H    . ASP A 1 152 ? 45.97536 -10.67922 6.62192  1.000 18.60255  ? 149 ASP A H    1 
ATOM   2332 H HA   . ASP A 1 152 ? 48.12509 -11.09228 5.00807  1.000 13.36093  ? 149 ASP A HA   1 
ATOM   2333 H HB2  . ASP A 1 152 ? 48.07410 -12.86573 6.55903  1.000 9.92168   ? 149 ASP A HB2  1 
ATOM   2334 H HB3  . ASP A 1 152 ? 46.70973 -13.31150 5.87697  1.000 9.92168   ? 149 ASP A HB3  1 
ATOM   2335 N N    . GLY A 1 153 ? 46.50294 -10.66161 3.23854  1.000 36.04921  ? 150 GLY A N    1 
ATOM   2336 C CA   . GLY A 1 153 ? 45.49850 -10.42980 2.22501  1.000 44.46461  ? 150 GLY A CA   1 
ATOM   2337 C C    . GLY A 1 153 ? 44.34895 -9.63270  2.82252  1.000 22.46336  ? 150 GLY A C    1 
ATOM   2338 O O    . GLY A 1 153 ? 44.52562 -8.52620  3.34375  1.000 20.86865  ? 150 GLY A O    1 
ATOM   2339 H H    . GLY A 1 153 ? 47.27813 -10.33100 3.06717  1.000 43.25906  ? 150 GLY A H    1 
ATOM   2340 H HA2  . GLY A 1 153 ? 45.88043 -9.93083  1.48606  1.000 53.35755  ? 150 GLY A HA2  1 
ATOM   2341 H HA3  . GLY A 1 153 ? 45.15938 -11.27578 1.89304  1.000 53.35755  ? 150 GLY A HA3  1 
ATOM   2342 N N    . LEU A 1 154 ? 43.13782 -10.17572 2.80235  1.000 20.12193  ? 151 LEU A N    1 
ATOM   2343 C CA   . LEU A 1 154 ? 41.98377 -9.38785  3.24803  1.000 26.12640  ? 151 LEU A CA   1 
ATOM   2344 C C    . LEU A 1 154 ? 41.53182 -9.76972  4.66017  1.000 16.75855  ? 151 LEU A C    1 
ATOM   2345 O O    . LEU A 1 154 ? 40.43821 -9.38160  5.08071  1.000 11.56924  ? 151 LEU A O    1 
ATOM   2346 C CB   . LEU A 1 154 ? 40.83590 -9.54688  2.23777  1.000 46.82395  ? 151 LEU A CB   1 
ATOM   2347 C CG   . LEU A 1 154 ? 40.20226 -10.94724 2.09697  1.000 58.82497  ? 151 LEU A CG   1 
ATOM   2348 C CD1  . LEU A 1 154 ? 39.00335 -11.10165 3.09797  1.000 48.01962  ? 151 LEU A CD1  1 
ATOM   2349 C CD2  . LEU A 1 154 ? 39.76616 -11.32561 0.65975  1.000 36.17671  ? 151 LEU A CD2  1 
ATOM   2350 H H    . LEU A 1 154 ? 42.95960 -10.97601 2.54279  1.000 24.14634  ? 151 LEU A H    1 
ATOM   2351 H HA   . LEU A 1 154 ? 42.22192 -8.44784  3.27210  1.000 31.35169  ? 151 LEU A HA   1 
ATOM   2352 H HB2  . LEU A 1 154 ? 40.12452 -8.94142  2.49902  1.000 56.18876  ? 151 LEU A HB2  1 
ATOM   2353 H HB3  . LEU A 1 154 ? 41.17487 -9.30241  1.36243  1.000 56.18876  ? 151 LEU A HB3  1 
ATOM   2354 H HG   . LEU A 1 154 ? 40.90117 -11.58309 2.31633  1.000 70.58998  ? 151 LEU A HG   1 
ATOM   2355 H HD11 . LEU A 1 154 ? 38.20655 -11.34509 2.60123  1.000 57.62356  ? 151 LEU A HD11 1 
ATOM   2356 H HD12 . LEU A 1 154 ? 39.21668 -11.79526 3.74163  1.000 57.62356  ? 151 LEU A HD12 1 
ATOM   2357 H HD13 . LEU A 1 154 ? 38.86310 -10.25780 3.55530  1.000 57.62356  ? 151 LEU A HD13 1 
ATOM   2358 H HD21 . LEU A 1 154 ? 39.39896 -12.22339 0.66720  1.000 43.41206  ? 151 LEU A HD21 1 
ATOM   2359 H HD22 . LEU A 1 154 ? 39.09335 -10.69554 0.35770  1.000 43.41206  ? 151 LEU A HD22 1 
ATOM   2360 H HD23 . LEU A 1 154 ? 40.53942 -11.28935 0.07524  1.000 43.41206  ? 151 LEU A HD23 1 
ATOM   2361 N N    . ILE A 1 155 ? 42.33706 -10.55489 5.37004  1.000 12.09388  ? 152 ILE A N    1 
ATOM   2362 C CA   . ILE A 1 155 ? 41.97417 -11.07331 6.67698  1.000 8.74116   ? 152 ILE A CA   1 
ATOM   2363 C C    . ILE A 1 155 ? 42.85411 -10.36928 7.69634  1.000 6.44719   ? 152 ILE A C    1 
ATOM   2364 O O    . ILE A 1 155 ? 44.07646 -10.50527 7.67880  1.000 6.07784   ? 152 ILE A O    1 
ATOM   2365 C CB   . ILE A 1 155 ? 42.17157 -12.58813 6.79132  1.000 11.79763  ? 152 ILE A CB   1 
ATOM   2366 C CG1  . ILE A 1 155 ? 41.33867 -13.34200 5.74197  1.000 15.17965  ? 152 ILE A CG1  1 
ATOM   2367 C CG2  . ILE A 1 155 ? 41.75613 -13.00991 8.18554  1.000 15.21792  ? 152 ILE A CG2  1 
ATOM   2368 C CD1  . ILE A 1 155 ? 39.85794 -13.21826 5.94210  1.000 26.64032  ? 152 ILE A CD1  1 
ATOM   2369 H H    . ILE A 1 155 ? 43.11634 -10.80455 5.10546  1.000 14.51267  ? 152 ILE A H    1 
ATOM   2370 H HA   . ILE A 1 155 ? 41.03887 -10.87388 6.83929  1.000 10.48940  ? 152 ILE A HA   1 
ATOM   2371 H HB   . ILE A 1 155 ? 43.10359 -12.80241 6.62907  1.000 14.15718  ? 152 ILE A HB   1 
ATOM   2372 H HG12 . ILE A 1 155 ? 41.54916 -12.98785 4.86380  1.000 18.21560  ? 152 ILE A HG12 1 
ATOM   2373 H HG13 . ILE A 1 155 ? 41.56501 -14.28434 5.78265  1.000 18.21560  ? 152 ILE A HG13 1 
ATOM   2374 H HG21 . ILE A 1 155 ? 41.59929 -13.96713 8.19232  1.000 18.26152  ? 152 ILE A HG21 1 
ATOM   2375 H HG22 . ILE A 1 155 ? 42.46602 -12.78663 8.80771  1.000 18.26152  ? 152 ILE A HG22 1 
ATOM   2376 H HG23 . ILE A 1 155 ? 40.94323 -12.53980 8.42863  1.000 18.26152  ? 152 ILE A HG23 1 
ATOM   2377 H HD11 . ILE A 1 155 ? 39.40232 -13.70881 5.24019  1.000 31.96840  ? 152 ILE A HD11 1 
ATOM   2378 H HD12 . ILE A 1 155 ? 39.62445 -13.58689 6.80841  1.000 31.96840  ? 152 ILE A HD12 1 
ATOM   2379 H HD13 . ILE A 1 155 ? 39.61138 -12.28089 5.90415  1.000 31.96840  ? 152 ILE A HD13 1 
ATOM   2380 N N    . LEU A 1 156 ? 42.22976 -9.64026  8.60891  1.000 6.05685   ? 153 LEU A N    1 
ATOM   2381 C CA   . LEU A 1 156 ? 42.95760 -8.88429  9.61358  1.000 7.76926   ? 153 LEU A CA   1 
ATOM   2382 C C    . LEU A 1 156 ? 42.55223 -9.41948  10.97565 1.000 5.16906   ? 153 LEU A C    1 
ATOM   2383 O O    . LEU A 1 156 ? 41.36074 -9.45940  11.30275 1.000 6.62081   ? 153 LEU A O    1 
ATOM   2384 C CB   . LEU A 1 156 ? 42.61606 -7.41429  9.44801  1.000 10.51508  ? 153 LEU A CB   1 
ATOM   2385 C CG   . LEU A 1 156 ? 43.47476 -6.44337  10.23343 1.000 14.50270  ? 153 LEU A CG   1 
ATOM   2386 C CD1  . LEU A 1 156 ? 43.29332 -5.14374  9.60060  1.000 30.84759  ? 153 LEU A CD1  1 
ATOM   2387 C CD2  . LEU A 1 156 ? 42.94847 -6.39117  11.60158 1.000 28.93352  ? 153 LEU A CD2  1 
ATOM   2388 H H    . LEU A 1 156 ? 41.37475 -9.56762  8.66620  1.000 7.26824   ? 153 LEU A H    1 
ATOM   2389 H HA   . LEU A 1 156 ? 43.91859 -8.99171  9.53699  1.000 9.32313   ? 153 LEU A HA   1 
ATOM   2390 H HB2  . LEU A 1 156 ? 42.70794 -7.18577  8.50980  1.000 12.61812  ? 153 LEU A HB2  1 
ATOM   2391 H HB3  . LEU A 1 156 ? 41.69835 -7.28254  9.73323  1.000 12.61812  ? 153 LEU A HB3  1 
ATOM   2392 H HG   . LEU A 1 156 ? 44.41198 -6.69240  10.25576 1.000 17.40326  ? 153 LEU A HG   1 
ATOM   2393 H HD11 . LEU A 1 156 ? 43.77543 -4.47411  10.11055 1.000 37.01712  ? 153 LEU A HD11 1 
ATOM   2394 H HD12 . LEU A 1 156 ? 43.63914 -5.18233  8.69516  1.000 37.01712  ? 153 LEU A HD12 1 
ATOM   2395 H HD13 . LEU A 1 156 ? 42.34738 -4.92961  9.58454  1.000 37.01712  ? 153 LEU A HD13 1 
ATOM   2396 H HD21 . LEU A 1 156 ? 43.37983 -5.66489  12.07838 1.000 34.72024  ? 153 LEU A HD21 1 
ATOM   2397 H HD22 . LEU A 1 156 ? 41.99084 -6.24086  11.56605 1.000 34.72024  ? 153 LEU A HD22 1 
ATOM   2398 H HD23 . LEU A 1 156 ? 43.13480 -7.23406  12.04399 1.000 34.72024  ? 153 LEU A HD23 1 
ATOM   2399 N N    . THR A 1 157 ? 43.53232 -9.87349  11.77473 1.000 3.63229   ? 154 THR A N    1 
ATOM   2400 C CA   . THR A 1 157 ? 43.11128 -10.48611 13.02898 1.000 5.97337   ? 154 THR A CA   1 
ATOM   2401 C C    . THR A 1 157 ? 43.93339 -9.91162  14.15852 1.000 4.56454   ? 154 THR A C    1 
ATOM   2402 O O    . THR A 1 157 ? 45.03001 -9.37041  13.95795 1.000 7.68283   ? 154 THR A O    1 
ATOM   2403 C CB   . THR A 1 157 ? 43.29751 -11.99191 13.00127 1.000 1.87578   ? 154 THR A CB   1 
ATOM   2404 O OG1  . THR A 1 157 ? 44.59944 -12.28273 12.48650 1.000 1.78535   ? 154 THR A OG1  1 
ATOM   2405 C CG2  . THR A 1 157 ? 42.24988 -12.65740 12.14346 1.000 0.80898   ? 154 THR A CG2  1 
ATOM   2406 H H    . THR A 1 157 ? 44.37702 -9.83705  11.61740 1.000 4.35876   ? 154 THR A H    1 
ATOM   2407 H HA   . THR A 1 157 ? 42.17411 -10.28969 13.18403 1.000 7.16806   ? 154 THR A HA   1 
ATOM   2408 H HB   . THR A 1 157 ? 43.20624 -12.34995 13.89814 1.000 2.25096   ? 154 THR A HB   1 
ATOM   2409 H HG1  . THR A 1 157 ? 44.67476 -11.97857 11.70713 1.000 2.14243   ? 154 THR A HG1  1 
ATOM   2410 H HG21 . THR A 1 157 ? 42.44036 -13.60506 12.06252 1.000 0.97079   ? 154 THR A HG21 1 
ATOM   2411 H HG22 . THR A 1 157 ? 41.37338 -12.54554 12.54362 1.000 0.97079   ? 154 THR A HG22 1 
ATOM   2412 H HG23 . THR A 1 157 ? 42.24480 -12.26061 11.25834 1.000 0.97079   ? 154 THR A HG23 1 
ATOM   2413 N N    . SER A 1 158 ? 43.45166 -10.10687 15.38367 1.000 4.02173   ? 155 SER A N    1 
ATOM   2414 C CA   . SER A 1 158 ? 44.19836 -9.54659  16.47413 1.000 2.70823   ? 155 SER A CA   1 
ATOM   2415 C C    . SER A 1 158 ? 43.89362 -10.35412 17.72699 1.000 7.05445   ? 155 SER A C    1 
ATOM   2416 O O    . SER A 1 158 ? 42.96329 -11.17606 17.73776 1.000 2.35218   ? 155 SER A O    1 
ATOM   2417 C CB   . SER A 1 158 ? 43.84137 -8.05726  16.59528 1.000 3.87489   ? 155 SER A CB   1 
ATOM   2418 O OG   . SER A 1 158 ? 44.64795 -7.43767  17.56570 1.000 1.09263   ? 155 SER A OG   1 
ATOM   2419 H H    . SER A 1 158 ? 42.73475 -10.53726 15.58465 1.000 4.82609   ? 155 SER A H    1 
ATOM   2420 H HA   . SER A 1 158 ? 45.15685 -9.61823  16.34354 1.000 3.24990   ? 155 SER A HA   1 
ATOM   2421 H HB2  . SER A 1 158 ? 43.98630 -7.62527  15.73896 1.000 4.64988   ? 155 SER A HB2  1 
ATOM   2422 H HB3  . SER A 1 158 ? 42.91068 -7.97393  16.85560 1.000 4.64988   ? 155 SER A HB3  1 
ATOM   2423 H HG   . SER A 1 158 ? 44.53105 -7.80363  18.31270 1.000 1.31118   ? 155 SER A HG   1 
ATOM   2424 N N    . ARG A 1 159 ? 44.63544 -10.09857 18.80964 1.000 7.12975   ? 156 ARG A N    1 
ATOM   2425 C CA   . ARG A 1 159 ? 44.67572 -11.15547 19.86359 1.000 4.55082   ? 156 ARG A CA   1 
ATOM   2426 C C    . ARG A 1 159 ? 43.73438 -10.98839 21.06171 1.000 11.02752  ? 156 ARG A C    1 
ATOM   2427 O O    . ARG A 1 159 ? 43.29115 -12.00983 21.59732 1.000 6.76098   ? 156 ARG A O    1 
ATOM   2428 C CB   . ARG A 1 159 ? 46.08152 -11.31086 20.41337 1.000 6.79420   ? 156 ARG A CB   1 
ATOM   2429 C CG   . ARG A 1 159 ? 47.19826 -11.49834 19.36432 1.000 5.75714   ? 156 ARG A CG   1 
ATOM   2430 C CD   . ARG A 1 159 ? 48.42605 -12.26350 19.96460 1.000 5.91721   ? 156 ARG A CD   1 
ATOM   2431 N NE   . ARG A 1 159 ? 48.18761 -13.71510 20.04646 1.000 8.09619   ? 156 ARG A NE   1 
ATOM   2432 C CZ   . ARG A 1 159 ? 48.99752 -14.58890 20.61539 1.000 8.94670   ? 156 ARG A CZ   1 
ATOM   2433 N NH1  . ARG A 1 159 ? 50.18343 -14.22616 21.09360 1.000 22.13337  ? 156 ARG A NH1  1 
ATOM   2434 N NH2  . ARG A 1 159 ? 48.61814 -15.85908 20.68919 1.000 13.52250  ? 156 ARG A NH2  1 
ATOM   2435 H H    . ARG A 1 159 ? 45.09088 -9.38388  18.95591 1.000 8.55571   ? 156 ARG A H    1 
ATOM   2436 H HA   . ARG A 1 159 ? 44.39512 -11.96460 19.40811 1.000 5.46100   ? 156 ARG A HA   1 
ATOM   2437 H HB2  . ARG A 1 159 ? 46.29766 -10.51467 20.92353 1.000 8.15305   ? 156 ARG A HB2  1 
ATOM   2438 H HB3  . ARG A 1 159 ? 46.09702 -12.08964 20.99143 1.000 8.15305   ? 156 ARG A HB3  1 
ATOM   2439 H HG2  . ARG A 1 159 ? 46.85428 -12.01227 18.61702 1.000 6.90858   ? 156 ARG A HG2  1 
ATOM   2440 H HG3  . ARG A 1 159 ? 47.50069 -10.62911 19.05795 1.000 6.90858   ? 156 ARG A HG3  1 
ATOM   2441 H HD2  . ARG A 1 159 ? 49.20103 -12.11543 19.40036 1.000 7.10067   ? 156 ARG A HD2  1 
ATOM   2442 H HD3  . ARG A 1 159 ? 48.60007 -11.93439 20.86031 1.000 7.10067   ? 156 ARG A HD3  1 
ATOM   2443 H HE   . ARG A 1 159 ? 47.46296 -14.01741 19.69562 1.000 9.71544   ? 156 ARG A HE   1 
ATOM   2444 H HH11 . ARG A 1 159 ? 50.43796 -13.40671 21.03598 1.000 26.56006  ? 156 ARG A HH11 1 
ATOM   2445 H HH12 . ARG A 1 159 ? 50.69623 -14.81091 21.46062 1.000 26.56006  ? 156 ARG A HH12 1 
ATOM   2446 H HH21 . ARG A 1 159 ? 47.85686 -16.09973 20.36960 1.000 16.22701  ? 156 ARG A HH21 1 
ATOM   2447 H HH22 . ARG A 1 159 ? 49.13368 -16.44118 21.05658 1.000 16.22701  ? 156 ARG A HH22 1 
ATOM   2448 N N    . GLY A 1 160 ? 43.45807 -9.78803  21.57445 1.000 7.16062   ? 157 GLY A N    1 
ATOM   2449 C CA   . GLY A 1 160 ? 42.64416 -9.70393  22.77769 1.000 7.44139   ? 157 GLY A CA   1 
ATOM   2450 C C    . GLY A 1 160 ? 42.22399 -8.29801  23.11884 1.000 6.07701   ? 157 GLY A C    1 
ATOM   2451 O O    . GLY A 1 160 ? 42.47271 -7.34940  22.36302 1.000 3.72848   ? 157 GLY A O    1 
ATOM   2452 H H    . GLY A 1 160 ? 43.72323 -9.03625  21.25178 1.000 8.59276   ? 157 GLY A H    1 
ATOM   2453 H HA2  . GLY A 1 160 ? 41.84278 -10.23681 22.65636 1.000 8.92968   ? 157 GLY A HA2  1 
ATOM   2454 H HA3  . GLY A 1 160 ? 43.14833 -10.05789 23.52697 1.000 8.92968   ? 157 GLY A HA3  1 
ATOM   2455 N N    . PRO A 1 161 ? 41.56181 -8.13066  24.27439 1.000 3.69304   ? 158 PRO A N    1 
ATOM   2456 C CA   . PRO A 1 161 ? 40.98255 -6.81501  24.56344 1.000 4.52031   ? 158 PRO A CA   1 
ATOM   2457 C C    . PRO A 1 161 ? 42.01521 -5.71927  24.56613 1.000 3.39231   ? 158 PRO A C    1 
ATOM   2458 O O    . PRO A 1 161 ? 41.80669 -4.62575  24.03578 1.000 4.43688   ? 158 PRO A O    1 
ATOM   2459 C CB   . PRO A 1 161 ? 40.31432 -7.03907  25.95684 1.000 10.65633  ? 158 PRO A CB   1 
ATOM   2460 C CG   . PRO A 1 161 ? 40.01795 -8.51084  26.01624 1.000 5.01433   ? 158 PRO A CG   1 
ATOM   2461 C CD   . PRO A 1 161 ? 41.22091 -9.15245  25.29526 1.000 4.00122   ? 158 PRO A CD   1 
ATOM   2462 H HA   . PRO A 1 161 ? 40.28776 -6.58810  23.92572 1.000 5.42439   ? 158 PRO A HA   1 
ATOM   2463 H HB2  . PRO A 1 161 ? 40.92771 -6.78006  26.66223 1.000 12.78762  ? 158 PRO A HB2  1 
ATOM   2464 H HB3  . PRO A 1 161 ? 39.49839 -6.51820  26.01889 1.000 12.78762  ? 158 PRO A HB3  1 
ATOM   2465 H HG2  . PRO A 1 161 ? 39.96256 -8.80573  26.93867 1.000 6.01722   ? 158 PRO A HG2  1 
ATOM   2466 H HG3  . PRO A 1 161 ? 39.18695 -8.70538  25.55528 1.000 6.01722   ? 158 PRO A HG3  1 
ATOM   2467 H HD2  . PRO A 1 161 ? 41.95977 -9.29357  25.90769 1.000 4.80148   ? 158 PRO A HD2  1 
ATOM   2468 H HD3  . PRO A 1 161 ? 40.97051 -9.99180  24.87848 1.000 4.80148   ? 158 PRO A HD3  1 
ATOM   2469 N N    . GLY A 1 162 ? 43.19788 -6.02683  25.10893 1.000 5.85269   ? 159 GLY A N    1 
ATOM   2470 C CA   . GLY A 1 162 ? 44.32534 -5.13292  25.18648 1.000 8.28753   ? 159 GLY A CA   1 
ATOM   2471 C C    . GLY A 1 162 ? 45.00908 -4.85173  23.85330 1.000 5.39488   ? 159 GLY A C    1 
ATOM   2472 O O    . GLY A 1 162 ? 45.91853 -4.02692  23.83076 1.000 9.71483   ? 159 GLY A O    1 
ATOM   2473 H H    . GLY A 1 162 ? 43.37044 -6.79453  25.45601 1.000 7.02324   ? 159 GLY A H    1 
ATOM   2474 H HA2  . GLY A 1 162 ? 44.02590 -4.28513  25.55046 1.000 9.94505   ? 159 GLY A HA2  1 
ATOM   2475 H HA3  . GLY A 1 162 ? 44.98654 -5.51695  25.78332 1.000 9.94505   ? 159 GLY A HA3  1 
ATOM   2476 N N    . THR A 1 163 ? 44.63024 -5.53864  22.76285 1.000 4.69101   ? 160 THR A N    1 
ATOM   2477 C CA   . THR A 1 163 ? 45.12987 -5.18234  21.45291 1.000 2.75301   ? 160 THR A CA   1 
ATOM   2478 C C    . THR A 1 163 ? 44.09291 -4.42602  20.65268 1.000 3.98153   ? 160 THR A C    1 
ATOM   2479 O O    . THR A 1 163 ? 44.30195 -4.15432  19.44137 1.000 3.56881   ? 160 THR A O    1 
ATOM   2480 C CB   . THR A 1 163 ? 45.58552 -6.41786  20.63508 1.000 8.09143   ? 160 THR A CB   1 
ATOM   2481 O OG1  . THR A 1 163 ? 44.50360 -7.31015  20.35389 1.000 3.11148   ? 160 THR A OG1  1 
ATOM   2482 C CG2  . THR A 1 163 ? 46.69138 -7.15472  21.42717 1.000 9.05761   ? 160 THR A CG2  1 
ATOM   2483 H H    . THR A 1 163 ? 44.08896 -6.20689  22.77077 1.000 5.62923   ? 160 THR A H    1 
ATOM   2484 H HA   . THR A 1 163 ? 45.91754 -4.63229  21.58678 1.000 3.30363   ? 160 THR A HA   1 
ATOM   2485 H HB   . THR A 1 163 ? 45.92955 -6.12436  19.77695 1.000 9.70973   ? 160 THR A HB   1 
ATOM   2486 H HG1  . THR A 1 163 ? 43.90258 -6.90743  19.92705 1.000 3.73380   ? 160 THR A HG1  1 
ATOM   2487 H HG21 . THR A 1 163 ? 46.98522 -7.93800  20.93622 1.000 10.86915  ? 160 THR A HG21 1 
ATOM   2488 H HG22 . THR A 1 163 ? 47.45001 -6.56589  21.56375 1.000 10.86915  ? 160 THR A HG22 1 
ATOM   2489 H HG23 . THR A 1 163 ? 46.35036 -7.43433  22.29113 1.000 10.86915  ? 160 THR A HG23 1 
ATOM   2490 N N    . SER A 1 164 ? 42.97094 -4.07745  21.29541 1.000 2.53409   ? 161 SER A N    1 
ATOM   2491 C CA   . SER A 1 164 ? 41.82598 -3.56003  20.56660 1.000 2.42734   ? 161 SER A CA   1 
ATOM   2492 C C    . SER A 1 164 ? 42.14793 -2.24429  19.89117 1.000 3.68971   ? 161 SER A C    1 
ATOM   2493 O O    . SER A 1 164 ? 41.62639 -1.95525  18.80814 1.000 4.43528   ? 161 SER A O    1 
ATOM   2494 C CB   . SER A 1 164 ? 40.64087 -3.33453  21.50154 1.000 7.40792   ? 161 SER A CB   1 
ATOM   2495 O OG   . SER A 1 164 ? 40.05901 -4.56910  21.89742 1.000 6.93436   ? 161 SER A OG   1 
ATOM   2496 H H    . SER A 1 164 ? 42.85501 -4.13299  22.14575 1.000 3.04093   ? 161 SER A H    1 
ATOM   2497 H HA   . SER A 1 164 ? 41.58657 -4.22315  19.90037 1.000 2.91282   ? 161 SER A HA   1 
ATOM   2498 H HB2  . SER A 1 164 ? 40.94869 -2.86395  22.29192 1.000 8.88952   ? 161 SER A HB2  1 
ATOM   2499 H HB3  . SER A 1 164 ? 39.97200 -2.80517  21.03971 1.000 8.88952   ? 161 SER A HB3  1 
ATOM   2500 H HG   . SER A 1 164 ? 39.42925 -4.43037  22.43571 1.000 8.32124   ? 161 SER A HG   1 
ATOM   2501 N N    . PHE A 1 165 ? 42.97408 -1.40456  20.54330 1.000 1.34462   ? 162 PHE A N    1 
ATOM   2502 C CA   . PHE A 1 165 ? 43.31601 -0.11563  19.90733 1.000 1.78872   ? 162 PHE A CA   1 
ATOM   2503 C C    . PHE A 1 165 ? 44.18352 -0.33685  18.67661 1.000 4.37008   ? 162 PHE A C    1 
ATOM   2504 O O    . PHE A 1 165 ? 44.02199 0.35851   17.66283 1.000 7.98875   ? 162 PHE A O    1 
ATOM   2505 C CB   . PHE A 1 165 ? 44.05411 0.81206   20.88322 1.000 4.44546   ? 162 PHE A CB   1 
ATOM   2506 C CG   . PHE A 1 165 ? 43.13100 1.51016   21.91015 1.000 6.04727   ? 162 PHE A CG   1 
ATOM   2507 C CD1  . PHE A 1 165 ? 42.35000 2.62631   21.54882 1.000 5.77144   ? 162 PHE A CD1  1 
ATOM   2508 C CD2  . PHE A 1 165 ? 43.05632 1.06745   23.20535 1.000 9.61758   ? 162 PHE A CD2  1 
ATOM   2509 C CE1  . PHE A 1 165 ? 41.50245 3.25851   22.47601 1.000 10.88813  ? 162 PHE A CE1  1 
ATOM   2510 C CE2  . PHE A 1 165 ? 42.18271 1.67667   24.10527 1.000 8.03741   ? 162 PHE A CE2  1 
ATOM   2511 C CZ   . PHE A 1 165 ? 41.43136 2.78996   23.73265 1.000 10.32144  ? 162 PHE A CZ   1 
ATOM   2512 H H    . PHE A 1 165 ? 43.33103 -1.54821  21.31242 1.000 1.61356   ? 162 PHE A H    1 
ATOM   2513 H HA   . PHE A 1 165 ? 42.48656 0.31807   19.65273 1.000 2.14649   ? 162 PHE A HA   1 
ATOM   2514 H HB2  . PHE A 1 165 ? 44.70343 0.28867   21.37855 1.000 5.33457   ? 162 PHE A HB2  1 
ATOM   2515 H HB3  . PHE A 1 165 ? 44.50463 1.50376   20.37384 1.000 5.33457   ? 162 PHE A HB3  1 
ATOM   2516 H HD1  . PHE A 1 165 ? 42.39611 2.95164   20.67880 1.000 6.92574   ? 162 PHE A HD1  1 
ATOM   2517 H HD2  . PHE A 1 165 ? 43.58986 0.35876   23.48463 1.000 11.54111  ? 162 PHE A HD2  1 
ATOM   2518 H HE1  . PHE A 1 165 ? 40.99525 3.99515   22.22104 1.000 13.06577  ? 162 PHE A HE1  1 
ATOM   2519 H HE2  . PHE A 1 165 ? 42.10017 1.33533   24.96641 1.000 9.64491   ? 162 PHE A HE2  1 
ATOM   2520 H HZ   . PHE A 1 165 ? 40.88068 3.20842   24.35436 1.000 12.38574  ? 162 PHE A HZ   1 
ATOM   2521 N N    . GLU A 1 166 ? 45.15181 -1.23949  18.76281 1.000 3.68619   ? 163 GLU A N    1 
ATOM   2522 C CA   . GLU A 1 166 ? 46.01060 -1.47448  17.61500 1.000 4.85276   ? 163 GLU A CA   1 
ATOM   2523 C C    . GLU A 1 166 ? 45.21151 -2.07467  16.48592 1.000 4.64600   ? 163 GLU A C    1 
ATOM   2524 O O    . GLU A 1 166 ? 45.35913 -1.69702  15.31683 1.000 6.98807   ? 163 GLU A O    1 
ATOM   2525 C CB   . GLU A 1 166 ? 47.16665 -2.36375  18.02903 1.000 3.34990   ? 163 GLU A CB   1 
ATOM   2526 C CG   . GLU A 1 166 ? 48.13556 -1.70221  18.97071 1.000 9.26199   ? 163 GLU A CG   1 
ATOM   2527 C CD   . GLU A 1 166 ? 48.68032 -2.69990  19.96903 1.000 32.80288  ? 163 GLU A CD   1 
ATOM   2528 O OE1  . GLU A 1 166 ? 49.68087 -3.39425  19.65480 1.000 20.96160  ? 163 GLU A OE1  1 
ATOM   2529 O OE2  . GLU A 1 166 ? 48.04412 -2.85600  21.03680 1.000 22.56267  ? 163 GLU A OE2  1 
ATOM   2530 H H    . GLU A 1 166 ? 45.32751 -1.71650  19.45649 1.000 4.42344   ? 163 GLU A H    1 
ATOM   2531 H HA   . GLU A 1 166 ? 46.39049 -0.64122  17.29523 1.000 5.82332   ? 163 GLU A HA   1 
ATOM   2532 H HB2  . GLU A 1 166 ? 46.81162 -3.14935  18.47365 1.000 4.01989   ? 163 GLU A HB2  1 
ATOM   2533 H HB3  . GLU A 1 166 ? 47.65810 -2.62571  17.23482 1.000 4.01989   ? 163 GLU A HB3  1 
ATOM   2534 H HG2  . GLU A 1 166 ? 48.87783 -1.33473  18.46583 1.000 11.11441  ? 163 GLU A HG2  1 
ATOM   2535 H HG3  . GLU A 1 166 ? 47.68287 -0.99544  19.45697 1.000 11.11441  ? 163 GLU A HG3  1 
ATOM   2536 N N    . PHE A 1 167 ? 44.30076 -2.96957  16.83400 1.000 3.95952   ? 164 PHE A N    1 
ATOM   2537 C CA   . PHE A 1 167 ? 43.41583 -3.58273  15.84506 1.000 2.98388   ? 164 PHE A CA   1 
ATOM   2538 C C    . PHE A 1 167 ? 42.59522 -2.52625  15.11801 1.000 9.94548   ? 164 PHE A C    1 
ATOM   2539 O O    . PHE A 1 167 ? 42.54481 -2.50915  13.87769 1.000 7.02023   ? 164 PHE A O    1 
ATOM   2540 C CB   . PHE A 1 167 ? 42.54921 -4.54632  16.62569 1.000 4.37054   ? 164 PHE A CB   1 
ATOM   2541 C CG   . PHE A 1 167 ? 41.41103 -5.16969  15.86849 1.000 2.35535   ? 164 PHE A CG   1 
ATOM   2542 C CD1  . PHE A 1 167 ? 41.66328 -6.10901  14.90742 1.000 7.94859   ? 164 PHE A CD1  1 
ATOM   2543 C CD2  . PHE A 1 167 ? 40.11513 -4.95951  16.24799 1.000 6.35043   ? 164 PHE A CD2  1 
ATOM   2544 C CE1  . PHE A 1 167 ? 40.61971 -6.77175  14.26475 1.000 4.76445   ? 164 PHE A CE1  1 
ATOM   2545 C CE2  . PHE A 1 167 ? 39.06520 -5.57846  15.59793 1.000 3.69877   ? 164 PHE A CE2  1 
ATOM   2546 C CZ   . PHE A 1 167 ? 39.32086 -6.52316  14.61247 1.000 7.84376   ? 164 PHE A CZ   1 
ATOM   2547 H H    . PHE A 1 167 ? 44.16975 -3.24404  17.63842 1.000 4.75144   ? 164 PHE A H    1 
ATOM   2548 H HA   . PHE A 1 167 ? 43.90318 -4.05624  15.15283 1.000 3.58068   ? 164 PHE A HA   1 
ATOM   2549 H HB2  . PHE A 1 167 ? 43.11138 -5.26963  16.94459 1.000 5.24466   ? 164 PHE A HB2  1 
ATOM   2550 H HB3  . PHE A 1 167 ? 42.16545 -4.06825  17.37741 1.000 5.24466   ? 164 PHE A HB3  1 
ATOM   2551 H HD1  . PHE A 1 167 ? 42.54274 -6.30809  14.67978 1.000 9.53833   ? 164 PHE A HD1  1 
ATOM   2552 H HD2  . PHE A 1 167 ? 39.93630 -4.38751  16.95914 1.000 7.62053   ? 164 PHE A HD2  1 
ATOM   2553 H HE1  . PHE A 1 167 ? 40.80799 -7.38794  13.59411 1.000 5.71736   ? 164 PHE A HE1  1 
ATOM   2554 H HE2  . PHE A 1 167 ? 38.18818 -5.36286  15.81987 1.000 4.43854   ? 164 PHE A HE2  1 
ATOM   2555 H HZ   . PHE A 1 167 ? 38.62320 -6.97722  14.19773 1.000 9.41252   ? 164 PHE A HZ   1 
ATOM   2556 N N    . ALA A 1 168 ? 41.92076 -1.65097  15.88677 1.000 4.27763   ? 165 ALA A N    1 
ATOM   2557 C CA   . ALA A 1 168 ? 41.10621 -0.58640  15.30086 1.000 4.52152   ? 165 ALA A CA   1 
ATOM   2558 C C    . ALA A 1 168 ? 41.91660 0.33623   14.39718 1.000 5.88057   ? 165 ALA A C    1 
ATOM   2559 O O    . ALA A 1 168 ? 41.49551 0.61889   13.26450 1.000 4.34232   ? 165 ALA A O    1 
ATOM   2560 C CB   . ALA A 1 168 ? 40.41044 0.19774   16.41381 1.000 7.49909   ? 165 ALA A CB   1 
ATOM   2561 H H    . ALA A 1 168 ? 41.92181 -1.65660  16.74676 1.000 5.13317   ? 165 ALA A H    1 
ATOM   2562 H HA   . ALA A 1 168 ? 40.42679 -0.99393  14.74122 1.000 5.42584   ? 165 ALA A HA   1 
ATOM   2563 H HB1  . ALA A 1 168 ? 39.84489 0.87752   16.01514 1.000 8.99892   ? 165 ALA A HB1  1 
ATOM   2564 H HB2  . ALA A 1 168 ? 39.87204 -0.41285  16.94126 1.000 8.99892   ? 165 ALA A HB2  1 
ATOM   2565 H HB3  . ALA A 1 168 ? 41.08327 0.61444   16.97468 1.000 8.99892   ? 165 ALA A HB3  1 
ATOM   2566 N N    . LEU A 1 169 ? 43.09929 0.81275   14.85726 1.000 3.75197   ? 166 LEU A N    1 
ATOM   2567 C CA   . LEU A 1 169 ? 43.94302 1.68539   14.02458 1.000 3.11192   ? 166 LEU A CA   1 
ATOM   2568 C C    . LEU A 1 169 ? 44.40696 0.98075   12.75903 1.000 6.68318   ? 166 LEU A C    1 
ATOM   2569 O O    . LEU A 1 169 ? 44.57458 1.61174   11.72425 1.000 3.38025   ? 166 LEU A O    1 
ATOM   2570 C CB   . LEU A 1 169 ? 45.14027 2.17694   14.81589 1.000 1.77719   ? 166 LEU A CB   1 
ATOM   2571 C CG   . LEU A 1 169 ? 44.77991 3.18929   15.89783 1.000 7.70200   ? 166 LEU A CG   1 
ATOM   2572 C CD1  . LEU A 1 169 ? 45.97484 3.60999   16.76762 1.000 17.19690  ? 166 LEU A CD1  1 
ATOM   2573 C CD2  . LEU A 1 169 ? 44.07862 4.40917   15.23267 1.000 9.27718   ? 166 LEU A CD2  1 
ATOM   2574 H H    . LEU A 1 169 ? 43.42509 0.64516   15.63531 1.000 4.50238   ? 166 LEU A H    1 
ATOM   2575 H HA   . LEU A 1 169 ? 43.41780 2.45844   13.76490 1.000 3.73432   ? 166 LEU A HA   1 
ATOM   2576 H HB2  . LEU A 1 169 ? 45.56249 1.41759   15.24718 1.000 2.13264   ? 166 LEU A HB2  1 
ATOM   2577 H HB3  . LEU A 1 169 ? 45.76420 2.60156   14.20654 1.000 2.13264   ? 166 LEU A HB3  1 
ATOM   2578 H HG   . LEU A 1 169 ? 44.16789 2.77072   16.52323 1.000 9.24242   ? 166 LEU A HG   1 
ATOM   2579 H HD11 . LEU A 1 169 ? 45.67719 4.26603   17.41717 1.000 20.63629  ? 166 LEU A HD11 1 
ATOM   2580 H HD12 . LEU A 1 169 ? 46.32445 2.82832   17.22334 1.000 20.63629  ? 166 LEU A HD12 1 
ATOM   2581 H HD13 . LEU A 1 169 ? 46.65961 3.99498   16.19860 1.000 20.63629  ? 166 LEU A HD13 1 
ATOM   2582 H HD21 . LEU A 1 169 ? 44.08309 5.15368   15.85444 1.000 11.13263  ? 166 LEU A HD21 1 
ATOM   2583 H HD22 . LEU A 1 169 ? 44.56053 4.64917   14.42579 1.000 11.13263  ? 166 LEU A HD22 1 
ATOM   2584 H HD23 . LEU A 1 169 ? 43.16535 4.16723   15.01290 1.000 11.13263  ? 166 LEU A HD23 1 
ATOM   2585 N N    . ALA A 1 170 ? 44.61489 -0.31953  12.82851 1.000 8.44430   ? 167 ALA A N    1 
ATOM   2586 C CA   . ALA A 1 170 ? 44.96077 -1.02484  11.59954 1.000 7.85942   ? 167 ALA A CA   1 
ATOM   2587 C C    . ALA A 1 170 ? 43.80653 -1.00602  10.60871 1.000 8.65070   ? 167 ALA A C    1 
ATOM   2588 O O    . ALA A 1 170 ? 44.02286 -0.92129  9.40152  1.000 12.16858  ? 167 ALA A O    1 
ATOM   2589 C CB   . ALA A 1 170 ? 45.34166 -2.46718  11.90767 1.000 14.46312  ? 167 ALA A CB   1 
ATOM   2590 H H    . ALA A 1 170 ? 44.56579 -0.80094  13.53946 1.000 10.13317  ? 167 ALA A H    1 
ATOM   2591 H HA   . ALA A 1 170 ? 45.72472 -0.58063  11.19960 1.000 9.43132   ? 167 ALA A HA   1 
ATOM   2592 H HB1  . ALA A 1 170 ? 45.58949 -2.91167  11.08189 1.000 17.35576  ? 167 ALA A HB1  1 
ATOM   2593 H HB2  . ALA A 1 170 ? 46.09120 -2.47124  12.52336 1.000 17.35576  ? 167 ALA A HB2  1 
ATOM   2594 H HB3  . ALA A 1 170 ? 44.58118 -2.91571  12.30941 1.000 17.35576  ? 167 ALA A HB3  1 
ATOM   2595 N N    . ILE A 1 171 ? 42.58487 -1.16081  11.08537 1.000 5.33152   ? 168 ILE A N    1 
ATOM   2596 C CA   . ILE A 1 171 ? 41.43971 -1.01916  10.18638 1.000 3.48626   ? 168 ILE A CA   1 
ATOM   2597 C C    . ILE A 1 171 ? 41.43645 0.37823   9.58343  1.000 15.16645  ? 168 ILE A C    1 
ATOM   2598 O O    . ILE A 1 171 ? 41.28957 0.55587   8.35802  1.000 12.44339  ? 168 ILE A O    1 
ATOM   2599 C CB   . ILE A 1 171 ? 40.14781 -1.31265  10.95165 1.000 6.39423   ? 168 ILE A CB   1 
ATOM   2600 C CG1  . ILE A 1 171 ? 40.06657 -2.77102  11.40412 1.000 8.46217   ? 168 ILE A CG1  1 
ATOM   2601 C CG2  . ILE A 1 171 ? 38.94857 -1.14949  10.07386 1.000 6.84329   ? 168 ILE A CG2  1 
ATOM   2602 C CD1  . ILE A 1 171 ? 38.85964 -3.05665  12.35396 1.000 14.19550  ? 168 ILE A CD1  1 
ATOM   2603 H H    . ILE A 1 171 ? 42.38941 -1.34348  11.90271 1.000 6.39784   ? 168 ILE A H    1 
ATOM   2604 H HA   . ILE A 1 171 ? 41.51098 -1.65849  9.46038  1.000 4.18353   ? 168 ILE A HA   1 
ATOM   2605 H HB   . ILE A 1 171 ? 40.16092 -0.69505  11.69952 1.000 7.67309   ? 168 ILE A HB   1 
ATOM   2606 H HG12 . ILE A 1 171 ? 39.97105 -3.33717  10.62230 1.000 10.15462  ? 168 ILE A HG12 1 
ATOM   2607 H HG13 . ILE A 1 171 ? 40.88072 -2.99754  11.88031 1.000 10.15462  ? 168 ILE A HG13 1 
ATOM   2608 H HG21 . ILE A 1 171 ? 38.17059 -1.50249  10.53325 1.000 8.21197   ? 168 ILE A HG21 1 
ATOM   2609 H HG22 . ILE A 1 171 ? 38.82152 -0.20662  9.88479  1.000 8.21197   ? 168 ILE A HG22 1 
ATOM   2610 H HG23 . ILE A 1 171 ? 39.09366 -1.63599  9.24732  1.000 8.21197   ? 168 ILE A HG23 1 
ATOM   2611 H HD11 . ILE A 1 171 ? 39.02050 -3.88758  12.82787 1.000 17.03462  ? 168 ILE A HD11 1 
ATOM   2612 H HD12 . ILE A 1 171 ? 38.77573 -2.32602  12.98645 1.000 17.03462  ? 168 ILE A HD12 1 
ATOM   2613 H HD13 . ILE A 1 171 ? 38.05076 -3.12958  11.82361 1.000 17.03462  ? 168 ILE A HD13 1 
ATOM   2614 N N    . VAL A 1 172 ? 41.63693 1.39760   10.42780 1.000 10.13525  ? 169 VAL A N    1 
ATOM   2615 C CA   . VAL A 1 172 ? 41.64068 2.75351   9.89170  1.000 5.31579   ? 169 VAL A CA   1 
ATOM   2616 C C    . VAL A 1 172 ? 42.71045 2.89354   8.79875  1.000 15.37668  ? 169 VAL A C    1 
ATOM   2617 O O    . VAL A 1 172 ? 42.42004 3.42383   7.71525  1.000 11.87653  ? 169 VAL A O    1 
ATOM   2618 C CB   . VAL A 1 172 ? 41.80177 3.80541   11.00297 1.000 6.18115   ? 169 VAL A CB   1 
ATOM   2619 C CG1  . VAL A 1 172 ? 41.97817 5.18912   10.33127 1.000 10.72753  ? 169 VAL A CG1  1 
ATOM   2620 C CG2  . VAL A 1 172 ? 40.54940 3.69921   11.84650 1.000 8.51759   ? 169 VAL A CG2  1 
ATOM   2621 H H    . VAL A 1 172 ? 41.76675 1.32935   11.27520 1.000 12.16232  ? 169 VAL A H    1 
ATOM   2622 H HA   . VAL A 1 172 ? 40.77545 2.91361   9.48348  1.000 6.37896   ? 169 VAL A HA   1 
ATOM   2623 H HB   . VAL A 1 172 ? 42.57567 3.67757   11.57361 1.000 7.41740   ? 169 VAL A HB   1 
ATOM   2624 H HG11 . VAL A 1 172 ? 41.81203 5.88276   10.98866 1.000 12.87305  ? 169 VAL A HG11 1 
ATOM   2625 H HG12 . VAL A 1 172 ? 42.88466 5.26323   9.99410  1.000 12.87305  ? 169 VAL A HG12 1 
ATOM   2626 H HG13 . VAL A 1 172 ? 41.34577 5.26811   9.60002  1.000 12.87305  ? 169 VAL A HG13 1 
ATOM   2627 H HG21 . VAL A 1 172 ? 40.60224 4.34046   12.57238 1.000 10.22113  ? 169 VAL A HG21 1 
ATOM   2628 H HG22 . VAL A 1 172 ? 39.77748 3.89096   11.29128 1.000 10.22113  ? 169 VAL A HG22 1 
ATOM   2629 H HG23 . VAL A 1 172 ? 40.48463 2.79974   12.20380 1.000 10.22113  ? 169 VAL A HG23 1 
ATOM   2630 N N    . GLU A 1 173 ? 43.94309 2.41572   9.05715  1.000 8.88780   ? 170 GLU A N    1 
ATOM   2631 C CA   . GLU A 1 173 ? 45.04083 2.52281   8.08848  1.000 15.38224  ? 170 GLU A CA   1 
ATOM   2632 C C    . GLU A 1 173 ? 44.69150 1.79229   6.77870  1.000 19.24739  ? 170 GLU A C    1 
ATOM   2633 O O    . GLU A 1 173 ? 44.91734 2.31203   5.68254  1.000 16.14891  ? 170 GLU A O    1 
ATOM   2634 C CB   . GLU A 1 173 ? 46.32393 2.01432   8.76758  1.000 14.42528  ? 170 GLU A CB   1 
ATOM   2635 C CG   . GLU A 1 173 ? 47.59061 2.08693   7.98076  1.000 36.38228  ? 170 GLU A CG   1 
ATOM   2636 C CD   . GLU A 1 173 ? 48.78286 1.69681   8.77310  1.000 39.26926  ? 170 GLU A CD   1 
ATOM   2637 O OE1  . GLU A 1 173 ? 48.75181 1.79103   10.04075 1.000 40.59093  ? 170 GLU A OE1  1 
ATOM   2638 O OE2  . GLU A 1 173 ? 49.71781 1.28445   8.05959  1.000 37.60540  ? 170 GLU A OE2  1 
ATOM   2639 H H    . GLU A 1 173 ? 44.16725 2.02437   9.78940  1.000 10.66538  ? 170 GLU A H    1 
ATOM   2640 H HA   . GLU A 1 173 ? 45.20333 3.44319   7.82888  1.000 18.45871  ? 170 GLU A HA   1 
ATOM   2641 H HB2  . GLU A 1 173 ? 46.46275 2.53805   9.57215  1.000 17.31035  ? 170 GLU A HB2  1 
ATOM   2642 H HB3  . GLU A 1 173 ? 46.18953 1.08169   8.99789  1.000 17.31035  ? 170 GLU A HB3  1 
ATOM   2643 H HG2  . GLU A 1 173 ? 47.52576 1.48672   7.22152  1.000 43.65875  ? 170 GLU A HG2  1 
ATOM   2644 H HG3  . GLU A 1 173 ? 47.71987 2.99784   7.67347  1.000 43.65875  ? 170 GLU A HG3  1 
ATOM   2645 N N    . ALA A 1 174 ? 43.99520 0.67630   6.86973  1.000 11.06512  ? 171 ALA A N    1 
ATOM   2646 C CA   . ALA A 1 174 ? 43.64899 -0.05121  5.65621  1.000 14.55320  ? 171 ALA A CA   1 
ATOM   2647 C C    . ALA A 1 174 ? 42.62440 0.69267   4.81539  1.000 17.97164  ? 171 ALA A C    1 
ATOM   2648 O O    . ALA A 1 174 ? 42.67487 0.64533   3.59154  1.000 15.64091  ? 171 ALA A O    1 
ATOM   2649 C CB   . ALA A 1 174 ? 43.08332 -1.41716  6.01170  1.000 12.47446  ? 171 ALA A CB   1 
ATOM   2650 H H    A ALA A 1 174 ? 43.71508 0.32273   7.60193  0.530 13.27816  ? 171 ALA A H    1 
ATOM   2651 H H    B ALA A 1 174 ? 43.71508 0.32273   7.60193  0.470 13.27816  ? 171 ALA A H    1 
ATOM   2652 H HA   . ALA A 1 174 ? 44.46170 -0.15730  5.13742  1.000 17.46386  ? 171 ALA A HA   1 
ATOM   2653 H HB1  . ALA A 1 174 ? 42.85998 -1.88899  5.19414  1.000 14.96937  ? 171 ALA A HB1  1 
ATOM   2654 H HB2  . ALA A 1 174 ? 43.75031 -1.91538  6.50948  1.000 14.96937  ? 171 ALA A HB2  1 
ATOM   2655 H HB3  . ALA A 1 174 ? 42.28722 -1.29816  6.55296  1.000 14.96937  ? 171 ALA A HB3  1 
ATOM   2656 N N    . LEU A 1 175 ? 41.64133 1.31012   5.46151  1.000 11.82313  ? 172 LEU A N    1 
ATOM   2657 C CA   . LEU A 1 175 ? 40.52819 1.93217   4.77398  1.000 12.75898  ? 172 LEU A CA   1 
ATOM   2658 C C    . LEU A 1 175 ? 40.88213 3.34690   4.32048  1.000 19.89894  ? 172 LEU A C    1 
ATOM   2659 O O    . LEU A 1 175 ? 40.65788 3.71240   3.15859  1.000 22.69557  ? 172 LEU A O    1 
ATOM   2660 C CB   . LEU A 1 175 ? 39.31590 1.95832   5.69178  1.000 15.88473  ? 172 LEU A CB   1 
ATOM   2661 C CG   . LEU A 1 175 ? 38.29322 0.85844   5.50987  1.000 16.98575  ? 172 LEU A CG   1 
ATOM   2662 C CD1  . LEU A 1 175 ? 39.03075 -0.35210  5.32033  1.000 17.76302  ? 172 LEU A CD1  1 
ATOM   2663 C CD2  . LEU A 1 175 ? 37.34940 0.70077   6.66883  1.000 22.19943  ? 172 LEU A CD2  1 
ATOM   2664 H H    . LEU A 1 175 ? 41.59928 1.38154   6.31751  1.000 14.18778  ? 172 LEU A H    1 
ATOM   2665 H HA   . LEU A 1 175 ? 40.29845 1.41113   3.98871  1.000 15.31079  ? 172 LEU A HA   1 
ATOM   2666 H HB2  . LEU A 1 175 ? 39.63292 1.90137   6.60674  1.000 19.06170  ? 172 LEU A HB2  1 
ATOM   2667 H HB3  . LEU A 1 175 ? 38.85411 2.79989   5.55245  1.000 19.06170  ? 172 LEU A HB3  1 
ATOM   2668 H HG   . LEU A 1 175 ? 37.72546 1.07429   4.75360  1.000 20.38292  ? 172 LEU A HG   1 
ATOM   2669 H HD11 . LEU A 1 175 ? 38.44135 -1.10776  5.47031  1.000 21.31564  ? 172 LEU A HD11 1 
ATOM   2670 H HD12 . LEU A 1 175 ? 39.37305 -0.37457  4.41301  1.000 21.31564  ? 172 LEU A HD12 1 
ATOM   2671 H HD13 . LEU A 1 175 ? 39.76641 -0.37590  5.95209  1.000 21.31564  ? 172 LEU A HD13 1 
ATOM   2672 H HD21 . LEU A 1 175 ? 36.70667 0.00486   6.46027  1.000 26.63933  ? 172 LEU A HD21 1 
ATOM   2673 H HD22 . LEU A 1 175 ? 37.85698 0.45638   7.45848  1.000 26.63933  ? 172 LEU A HD22 1 
ATOM   2674 H HD23 . LEU A 1 175 ? 36.88960 1.54169   6.81832  1.000 26.63933  ? 172 LEU A HD23 1 
ATOM   2675 N N    . ASN A 1 176 ? 41.46028 4.13310   5.22389  1.000 17.30060  ? 173 ASN A N    1 
ATOM   2676 C CA   . ASN A 1 176 ? 41.68887 5.55845   5.01350  1.000 8.24656   ? 173 ASN A CA   1 
ATOM   2677 C C    . ASN A 1 176 ? 43.13882 5.97015   4.93393  1.000 17.99029  ? 173 ASN A C    1 
ATOM   2678 O O    . ASN A 1 176 ? 43.41517 7.16804   4.74771  1.000 17.84831  ? 173 ASN A O    1 
ATOM   2679 C CB   . ASN A 1 176 ? 41.08287 6.38359   6.12155  1.000 9.77178   ? 173 ASN A CB   1 
ATOM   2680 C CG   . ASN A 1 176 ? 39.61848 6.17665   6.25429  1.000 22.71288  ? 173 ASN A CG   1 
ATOM   2681 O OD1  . ASN A 1 176 ? 39.11274 6.05448   7.33237  1.000 45.30440  ? 173 ASN A OD1  1 
ATOM   2682 N ND2  . ASN A 1 176 ? 38.94103 6.14456   5.15126  1.000 29.68848  ? 173 ASN A ND2  1 
ATOM   2683 H H    . ASN A 1 176 ? 41.73701 3.85546   5.98935  1.000 20.76074  ? 173 ASN A H    1 
ATOM   2684 H HA   . ASN A 1 176 ? 41.25495 5.75754   4.16912  1.000 9.89589   ? 173 ASN A HA   1 
ATOM   2685 H HB2  . ASN A 1 176 ? 41.49837 6.13751   6.96280  1.000 11.72615  ? 173 ASN A HB2  1 
ATOM   2686 H HB3  . ASN A 1 176 ? 41.23785 7.32324   5.93733  1.000 11.72615  ? 173 ASN A HB3  1 
ATOM   2687 H HD21 . ASN A 1 176 ? 38.08935 6.02724   5.17296  1.000 35.62619  ? 173 ASN A HD21 1 
ATOM   2688 H HD22 . ASN A 1 176 ? 39.34278 6.24057   4.39695  1.000 35.62619  ? 173 ASN A HD22 1 
ATOM   2689 N N    . GLY A 1 177 ? 44.07063 5.07607   5.19110  1.000 11.78544  ? 174 GLY A N    1 
ATOM   2690 C CA   . GLY A 1 177 ? 45.47402 5.39603   5.02883  1.000 21.99738  ? 174 GLY A CA   1 
ATOM   2691 C C    . GLY A 1 177 ? 46.19618 5.76456   6.32128  1.000 30.15404  ? 174 GLY A C    1 
ATOM   2692 O O    . GLY A 1 177 ? 45.60305 6.11012   7.35225  1.000 16.18369  ? 174 GLY A O    1 
ATOM   2693 H H    . GLY A 1 177 ? 43.91584 4.27456   5.46169  1.000 14.14254  ? 174 GLY A H    1 
ATOM   2694 H HA2  . GLY A 1 177 ? 45.92689 4.62875   4.64529  1.000 26.39687  ? 174 GLY A HA2  1 
ATOM   2695 H HA3  . GLY A 1 177 ? 45.55471 6.14708   4.42031  1.000 26.39687  ? 174 GLY A HA3  1 
ATOM   2696 N N    . LYS A 1 178 ? 47.52476 5.75170   6.21393  1.000 16.30400  ? 175 LYS A N    1 
ATOM   2697 C CA   . LYS A 1 178 ? 48.38364 5.88493   7.38334  1.000 22.53341  ? 175 LYS A CA   1 
ATOM   2698 C C    . LYS A 1 178 ? 48.27267 7.26057   8.03939  1.000 29.92850  ? 175 LYS A C    1 
ATOM   2699 O O    . LYS A 1 178 ? 48.42782 7.37642   9.26786  1.000 21.91057  ? 175 LYS A O    1 
ATOM   2700 C CB   . LYS A 1 178 ? 49.82246 5.56276   6.94832  1.000 26.91572  ? 175 LYS A CB   1 
ATOM   2701 C CG   . LYS A 1 178 ? 50.90415 5.62891   8.03619  1.000 67.14458  ? 175 LYS A CG   1 
ATOM   2702 C CD   . LYS A 1 178 ? 51.79151 6.95224   7.90828  1.000 94.10950  ? 175 LYS A CD   1 
ATOM   2703 C CE   . LYS A 1 178 ? 53.16108 6.91876   8.65124  1.000 85.11837  ? 175 LYS A CE   1 
ATOM   2704 N NZ   . LYS A 1 178 ? 54.13139 6.06372   7.87990  1.000 89.74552  ? 175 LYS A NZ   1 
ATOM   2705 H H    . LYS A 1 178 ? 47.95328 5.66687   5.47314  1.000 19.56481  ? 175 LYS A H    1 
ATOM   2706 H HA   . LYS A 1 178 ? 48.11852 5.25351   8.07030  1.000 27.04011  ? 175 LYS A HA   1 
ATOM   2707 H HB2  . LYS A 1 178 ? 49.83352 4.66055   6.59223  1.000 32.29888  ? 175 LYS A HB2  1 
ATOM   2708 H HB3  . LYS A 1 178 ? 50.07601 6.19508   6.25782  1.000 32.29888  ? 175 LYS A HB3  1 
ATOM   2709 H HG2  . LYS A 1 178 ? 50.48114 5.62982   8.90910  1.000 80.57352  ? 175 LYS A HG2  1 
ATOM   2710 H HG3  . LYS A 1 178 ? 51.49034 4.86063   7.95240  1.000 80.57352  ? 175 LYS A HG3  1 
ATOM   2711 H HD2  . LYS A 1 178 ? 51.97791 7.10552   6.96878  1.000 112.93141 ? 175 LYS A HD2  1 
ATOM   2712 H HD3  . LYS A 1 178 ? 51.28553 7.69574   8.27172  1.000 112.93141 ? 175 LYS A HD3  1 
ATOM   2713 H HE2  . LYS A 1 178 ? 53.52033 7.81724   8.71879  1.000 102.14206 ? 175 LYS A HE2  1 
ATOM   2714 H HE3  . LYS A 1 178 ? 53.04536 6.54028   9.53682  1.000 102.14206 ? 175 LYS A HE3  1 
ATOM   2715 H HZ1  . LYS A 1 178 ? 54.91904 6.04792   8.29399  1.000 107.69464 ? 175 LYS A HZ1  1 
ATOM   2716 H HZ2  . LYS A 1 178 ? 53.82115 5.23189   7.81747  1.000 107.69464 ? 175 LYS A HZ2  1 
ATOM   2717 H HZ3  . LYS A 1 178 ? 54.24242 6.39284   7.06048  1.000 107.69464 ? 175 LYS A HZ3  1 
ATOM   2718 N N    . GLU A 1 179 ? 47.97877 8.31464   7.26761  1.000 18.75748  ? 176 GLU A N    1 
ATOM   2719 C CA   A GLU A 1 179 ? 47.96791 9.65177   7.85513  0.503 21.88731  ? 176 GLU A CA   1 
ATOM   2720 C CA   B GLU A 1 179 ? 47.96895 9.64654   7.86392  0.497 21.89057  ? 176 GLU A CA   1 
ATOM   2721 C C    . GLU A 1 179 ? 46.70656 9.88857   8.67067  1.000 15.83058  ? 176 GLU A C    1 
ATOM   2722 O O    . GLU A 1 179 ? 46.74703 10.55089  9.70467  1.000 12.46699  ? 176 GLU A O    1 
ATOM   2723 C CB   A GLU A 1 179 ? 48.09385 10.70559  6.75611  0.503 26.16279  ? 176 GLU A CB   1 
ATOM   2724 C CB   B GLU A 1 179 ? 48.09546 10.72093  6.79213  0.497 26.15644  ? 176 GLU A CB   1 
ATOM   2725 C CG   A GLU A 1 179 ? 49.39127 10.61777  5.95093  0.503 40.92413  ? 176 GLU A CG   1 
ATOM   2726 C CG   B GLU A 1 179 ? 48.12870 12.12321  7.38097  0.497 33.92396  ? 176 GLU A CG   1 
ATOM   2727 C CD   A GLU A 1 179 ? 49.36335 11.48536  4.69372  0.503 53.49751  ? 176 GLU A CD   1 
ATOM   2728 C CD   B GLU A 1 179 ? 48.22709 13.21255  6.32159  0.497 49.11470  ? 176 GLU A CD   1 
ATOM   2729 O OE1  A GLU A 1 179 ? 48.78962 12.60320  4.75052  0.503 62.92892  ? 176 GLU A OE1  1 
ATOM   2730 O OE1  B GLU A 1 179 ? 47.62471 13.06416  5.22998  0.497 42.02555  ? 176 GLU A OE1  1 
ATOM   2731 O OE2  A GLU A 1 179 ? 49.90534 11.03565  3.65197  0.503 51.26853  ? 176 GLU A OE2  1 
ATOM   2732 O OE2  B GLU A 1 179 ? 48.92378 14.21825  6.58361  0.497 46.43426  ? 176 GLU A OE2  1 
ATOM   2733 H H    A GLU A 1 179 ? 47.78887 8.28049   6.42953  0.503 22.50899  ? 176 GLU A H    1 
ATOM   2734 H H    B GLU A 1 179 ? 47.78941 8.28294   6.42932  0.497 22.50899  ? 176 GLU A H    1 
ATOM   2735 H HA   A GLU A 1 179 ? 48.73086 9.73641   8.44814  0.503 26.26479  ? 176 GLU A HA   1 
ATOM   2736 H HA   B GLU A 1 179 ? 48.73627 9.70856   8.45407  0.497 26.26869  ? 176 GLU A HA   1 
ATOM   2737 H HB2  A GLU A 1 179 ? 47.35507 10.59790  6.13683  0.503 31.39536  ? 176 GLU A HB2  1 
ATOM   2738 H HB2  B GLU A 1 179 ? 48.91840 10.58099  6.29808  0.497 31.38775  ? 176 GLU A HB2  1 
ATOM   2739 H HB3  A GLU A 1 179 ? 48.05934 11.58498  7.16400  0.503 31.39536  ? 176 GLU A HB3  1 
ATOM   2740 H HB3  B GLU A 1 179 ? 47.33483 10.66264  6.19301  0.497 31.38775  ? 176 GLU A HB3  1 
ATOM   2741 H HG2  A GLU A 1 179 ? 50.12886 10.91637  6.50564  0.503 49.10897  ? 176 GLU A HG2  1 
ATOM   2742 H HG2  B GLU A 1 179 ? 47.31472 12.27159  7.88726  0.497 40.70877  ? 176 GLU A HG2  1 
ATOM   2743 H HG3  A GLU A 1 179 ? 49.53271 9.69779   5.67794  0.503 49.10897  ? 176 GLU A HG3  1 
ATOM   2744 H HG3  B GLU A 1 179 ? 48.90055 12.20215  7.96314  0.497 40.70877  ? 176 GLU A HG3  1 
ATOM   2745 N N    . VAL A 1 180 ? 45.57963 9.38117   8.20035  1.000 10.75023  ? 177 VAL A N    1 
ATOM   2746 C CA   . VAL A 1 180 ? 44.37185 9.48962   8.99548  1.000 15.85639  ? 177 VAL A CA   1 
ATOM   2747 C C    . VAL A 1 180 ? 44.54669 8.69746   10.27981 1.000 10.62736  ? 177 VAL A C    1 
ATOM   2748 O O    . VAL A 1 180 ? 44.15559 9.14902   11.35648 1.000 7.81468   ? 177 VAL A O    1 
ATOM   2749 C CB   . VAL A 1 180 ? 43.18033 9.02366   8.16699  1.000 16.28960  ? 177 VAL A CB   1 
ATOM   2750 C CG1  . VAL A 1 180 ? 41.96271 8.90637   8.96634  1.000 12.73217  ? 177 VAL A CG1  1 
ATOM   2751 C CG2  . VAL A 1 180 ? 42.83908 10.10089  7.14834  1.000 16.83934  ? 177 VAL A CG2  1 
ATOM   2752 H H    . VAL A 1 180 ? 45.48991 8.98026   7.44483  1.000 12.90029  ? 177 VAL A H    1 
ATOM   2753 H HA   . VAL A 1 180 ? 44.20829 10.41326  9.24252  1.000 19.02769  ? 177 VAL A HA   1 
ATOM   2754 H HB   . VAL A 1 180 ? 43.42728 8.16951   7.77924  1.000 19.54754  ? 177 VAL A HB   1 
ATOM   2755 H HG11 . VAL A 1 180 ? 41.19987 8.83610   8.37133  1.000 15.27862  ? 177 VAL A HG11 1 
ATOM   2756 H HG12 . VAL A 1 180 ? 42.02406 8.11273   9.52065  1.000 15.27862  ? 177 VAL A HG12 1 
ATOM   2757 H HG13 . VAL A 1 180 ? 41.87476 9.69424   9.52528  1.000 15.27862  ? 177 VAL A HG13 1 
ATOM   2758 H HG21 . VAL A 1 180 ? 42.07819 9.80859   6.62249  1.000 20.20723  ? 177 VAL A HG21 1 
ATOM   2759 H HG22 . VAL A 1 180 ? 42.62132 10.92151  7.61745  1.000 20.20723  ? 177 VAL A HG22 1 
ATOM   2760 H HG23 . VAL A 1 180 ? 43.60521 10.24339  6.57073  1.000 20.20723  ? 177 VAL A HG23 1 
ATOM   2761 N N    . ALA A 1 181 ? 45.15169 7.51393   10.18778 1.000 11.45657  ? 178 ALA A N    1 
ATOM   2762 C CA   . ALA A 1 181 ? 45.35755 6.71352   11.37696 1.000 14.68543  ? 178 ALA A CA   1 
ATOM   2763 C C    . ALA A 1 181 ? 46.21501 7.48017   12.38191 1.000 11.99084  ? 178 ALA A C    1 
ATOM   2764 O O    . ALA A 1 181 ? 45.92301 7.48032   13.58177 1.000 10.41087  ? 178 ALA A O    1 
ATOM   2765 C CB   . ALA A 1 181 ? 46.02856 5.39106   11.01771 1.000 15.97766  ? 178 ALA A CB   1 
ATOM   2766 H H    . ALA A 1 181 ? 45.44495 7.16304   9.45944  1.000 13.74790  ? 178 ALA A H    1 
ATOM   2767 H HA   . ALA A 1 181 ? 44.49797 6.51027   11.77784 1.000 17.62254  ? 178 ALA A HA   1 
ATOM   2768 H HB1  . ALA A 1 181 ? 46.20165 4.89329   11.83206 1.000 19.17321  ? 178 ALA A HB1  1 
ATOM   2769 H HB2  . ALA A 1 181 ? 45.43760 4.88395   10.43934 1.000 19.17321  ? 178 ALA A HB2  1 
ATOM   2770 H HB3  . ALA A 1 181 ? 46.86308 5.57482   10.55866 1.000 19.17321  ? 178 ALA A HB3  1 
ATOM   2771 N N    . ALA A 1 182 ? 47.29075 8.10497   11.89958 1.000 9.18006   ? 179 ALA A N    1 
ATOM   2772 C CA   . ALA A 1 182 ? 48.18070 8.83955   12.76940 1.000 8.87960   ? 179 ALA A CA   1 
ATOM   2773 C C    . ALA A 1 182 ? 47.45486 10.02167  13.39403 1.000 12.99315  ? 179 ALA A C    1 
ATOM   2774 O O    . ALA A 1 182 ? 47.61819 10.30830  14.58901 1.000 11.46167  ? 179 ALA A O    1 
ATOM   2775 C CB   . ALA A 1 182 ? 49.41539 9.33756   12.02210 1.000 16.34308  ? 179 ALA A CB   1 
ATOM   2776 H H    . ALA A 1 182 ? 47.52075 8.11409   11.07096 1.000 11.01608  ? 179 ALA A H    1 
ATOM   2777 H HA   . ALA A 1 182 ? 48.48632 8.23438   13.46313 1.000 10.65554  ? 179 ALA A HA   1 
ATOM   2778 H HB1  . ALA A 1 182 ? 49.97651 9.83628   12.63637 1.000 19.61171  ? 179 ALA A HB1  1 
ATOM   2779 H HB2  . ALA A 1 182 ? 49.90285 8.57465   11.67389 1.000 19.61171  ? 179 ALA A HB2  1 
ATOM   2780 H HB3  . ALA A 1 182 ? 49.13299 9.91078   11.29233 1.000 19.61171  ? 179 ALA A HB3  1 
ATOM   2781 N N    . GLN A 1 183 ? 46.59808 10.67222  12.62514 1.000 7.27466   ? 180 GLN A N    1 
ATOM   2782 C CA   A GLN A 1 183 ? 45.86293 11.84157  13.11809 0.532 12.18310  ? 180 GLN A CA   1 
ATOM   2783 C CA   B GLN A 1 183 ? 45.89109 11.84567  13.14431 0.468 12.14545  ? 180 GLN A CA   1 
ATOM   2784 C C    . GLN A 1 183 ? 44.82441 11.45997  14.17045 1.000 8.81786   ? 180 GLN A C    1 
ATOM   2785 O O    . GLN A 1 183 ? 44.60939 12.18688  15.14375 1.000 9.17068   ? 180 GLN A O    1 
ATOM   2786 C CB   A GLN A 1 183 ? 45.14873 12.53449  11.95131 0.532 10.91636  ? 180 GLN A CB   1 
ATOM   2787 C CB   B GLN A 1 183 ? 45.27837 12.63541  11.98112 0.468 11.26572  ? 180 GLN A CB   1 
ATOM   2788 C CG   A GLN A 1 183 ? 46.02093 13.11726  10.88951 0.532 19.04735  ? 180 GLN A CG   1 
ATOM   2789 C CG   B GLN A 1 183 ? 46.31217 13.48442  11.21076 0.468 14.66028  ? 180 GLN A CG   1 
ATOM   2790 C CD   A GLN A 1 183 ? 45.23779 13.58274  9.65585  0.532 20.84547  ? 180 GLN A CD   1 
ATOM   2791 C CD   B GLN A 1 183 ? 47.08009 14.44657  12.11117 0.468 23.44921  ? 180 GLN A CD   1 
ATOM   2792 O OE1  A GLN A 1 183 ? 44.03477 13.27996  9.43239  0.532 12.94970  ? 180 GLN A OE1  1 
ATOM   2793 O OE1  B GLN A 1 183 ? 46.49476 15.29131  12.80518 0.468 16.38369  ? 180 GLN A OE1  1 
ATOM   2794 N NE2  A GLN A 1 183 ? 45.93586 14.36514  8.85631  0.532 21.26889  ? 180 GLN A NE2  1 
ATOM   2795 N NE2  B GLN A 1 183 ? 48.40543 14.30607  12.11433 0.468 23.20495  ? 180 GLN A NE2  1 
ATOM   2796 H H    A GLN A 1 183 ? 46.41761 10.46327  11.81066 0.532 8.72961   ? 180 GLN A H    1 
ATOM   2797 H H    B GLN A 1 183 ? 46.40619 10.46470  11.81291 0.468 8.72961   ? 180 GLN A H    1 
ATOM   2798 H HA   A GLN A 1 183 ? 46.50400 12.44958  13.51842 0.532 14.61974  ? 180 GLN A HA   1 
ATOM   2799 H HA   B GLN A 1 183 ? 46.52820 12.42001  13.59722 0.468 14.57455  ? 180 GLN A HA   1 
ATOM   2800 H HB2  A GLN A 1 183 ? 44.57307 11.88313  11.52090 0.532 13.09965  ? 180 GLN A HB2  1 
ATOM   2801 H HB2  B GLN A 1 183 ? 44.87800 12.01210  11.35495 0.468 13.51888  ? 180 GLN A HB2  1 
ATOM   2802 H HB3  A GLN A 1 183 ? 44.61632 13.26048  12.31239 0.532 13.09965  ? 180 GLN A HB3  1 
ATOM   2803 H HB3  B GLN A 1 183 ? 44.60106 13.23509  12.33117 0.468 13.51888  ? 180 GLN A HB3  1 
ATOM   2804 H HG2  A GLN A 1 183 ? 46.48912 13.88508  11.25304 0.532 22.85684  ? 180 GLN A HG2  1 
ATOM   2805 H HG2  B GLN A 1 183 ? 46.95440 12.89275  10.78843 0.468 17.59235  ? 180 GLN A HG2  1 
ATOM   2806 H HG3  A GLN A 1 183 ? 46.65872 12.44530  10.60213 0.532 22.85684  ? 180 GLN A HG3  1 
ATOM   2807 H HG3  B GLN A 1 183 ? 45.85098 14.00846  10.53728 0.468 17.59235  ? 180 GLN A HG3  1 
ATOM   2808 H HE21 A GLN A 1 183 ? 46.74880 14.56537  9.05286  0.532 25.52268  ? 180 GLN A HE21 1 
ATOM   2809 H HE21 B GLN A 1 183 ? 48.77483 13.70079  11.62773 0.468 27.84595  ? 180 GLN A HE21 1 
ATOM   2810 H HE22 A GLN A 1 183 ? 45.57820 14.67520  8.13829  0.532 25.52268  ? 180 GLN A HE22 1 
ATOM   2811 H HE22 B GLN A 1 183 ? 48.89123 14.82069  12.60295 0.468 27.84595  ? 180 GLN A HE22 1 
ATOM   2812 N N    . VAL A 1 184 ? 44.12756 10.32862  13.96418 1.000 7.16857   ? 181 VAL A N    1 
ATOM   2813 C CA   . VAL A 1 184 ? 43.17113 9.84665   14.94292 1.000 8.89128   ? 181 VAL A CA   1 
ATOM   2814 C C    . VAL A 1 184 ? 43.85720 9.32263   16.21154 1.000 7.89480   ? 181 VAL A C    1 
ATOM   2815 O O    . VAL A 1 184 ? 43.29012 9.39286   17.28882 1.000 3.53672   ? 181 VAL A O    1 
ATOM   2816 C CB   . VAL A 1 184 ? 42.29884 8.74586   14.30690 1.000 14.26791  ? 181 VAL A CB   1 
ATOM   2817 C CG1  . VAL A 1 184 ? 41.50041 7.98401   15.37049 1.000 15.08708  ? 181 VAL A CG1  1 
ATOM   2818 C CG2  . VAL A 1 184 ? 41.41015 9.40767   13.26286 1.000 15.70244  ? 181 VAL A CG2  1 
ATOM   2819 H H    . VAL A 1 184 ? 44.19738 9.83173   13.26573 1.000 8.60230   ? 181 VAL A H    1 
ATOM   2820 H HA   . VAL A 1 184 ? 42.61414 10.59608  15.20565 1.000 10.66956  ? 181 VAL A HA   1 
ATOM   2821 H HB   . VAL A 1 184 ? 42.84695 8.07335   13.87306 1.000 17.12151  ? 181 VAL A HB   1 
ATOM   2822 H HG11 . VAL A 1 184 ? 40.77421 7.50727   14.93893 1.000 18.10451  ? 181 VAL A HG11 1 
ATOM   2823 H HG12 . VAL A 1 184 ? 42.08903 7.35579   15.81745 1.000 18.10451  ? 181 VAL A HG12 1 
ATOM   2824 H HG13 . VAL A 1 184 ? 41.14447 8.61804   16.01252 1.000 18.10451  ? 181 VAL A HG13 1 
ATOM   2825 H HG21 . VAL A 1 184 ? 40.85028 8.73148   12.85028 1.000 18.84294  ? 181 VAL A HG21 1 
ATOM   2826 H HG22 . VAL A 1 184 ? 40.85666 10.07562  13.69690 1.000 18.84294  ? 181 VAL A HG22 1 
ATOM   2827 H HG23 . VAL A 1 184 ? 41.97047 9.82775   12.59169 1.000 18.84294  ? 181 VAL A HG23 1 
ATOM   2828 N N    . LYS A 1 185 ? 45.05233 8.74876   16.07188 1.000 7.59044   ? 182 LYS A N    1 
ATOM   2829 C CA   . LYS A 1 185 ? 45.74966 8.15028   17.19558 1.000 5.58102   ? 182 LYS A CA   1 
ATOM   2830 C C    . LYS A 1 185 ? 46.20684 9.19712   18.20585 1.000 8.50905   ? 182 LYS A C    1 
ATOM   2831 O O    . LYS A 1 185 ? 46.18153 8.94917   19.42406 1.000 9.20378   ? 182 LYS A O    1 
ATOM   2832 C CB   . LYS A 1 185 ? 46.95533 7.37167   16.66210 1.000 5.62999   ? 182 LYS A CB   1 
ATOM   2833 C CG   . LYS A 1 185 ? 47.89424 6.87265   17.72196 1.000 17.21069  ? 182 LYS A CG   1 
ATOM   2834 C CD   . LYS A 1 185 ? 49.07355 6.09725   17.09515 1.000 13.22024  ? 182 LYS A CD   1 
ATOM   2835 C CE   . LYS A 1 185 ? 50.17500 5.83651   18.13340 1.000 43.76539  ? 182 LYS A CE   1 
ATOM   2836 N NZ   . LYS A 1 185 ? 51.28216 4.96507   17.57391 1.000 62.92859  ? 182 LYS A NZ   1 
ATOM   2837 H H    A LYS A 1 185 ? 45.48141 8.69436   15.32856 0.991 9.10855   ? 182 LYS A H    1 
ATOM   2838 H H    B LYS A 1 185 ? 45.48141 8.69436   15.32856 0.009 9.10855   ? 182 LYS A H    1 
ATOM   2839 H HA   . LYS A 1 185 ? 45.14872 7.54500   17.65753 1.000 6.69724   ? 182 LYS A HA   1 
ATOM   2840 H HB2  . LYS A 1 185 ? 46.63190 6.60037   16.17079 1.000 6.75601   ? 182 LYS A HB2  1 
ATOM   2841 H HB3  . LYS A 1 185 ? 47.46143 7.95226   16.07245 1.000 6.75601   ? 182 LYS A HB3  1 
ATOM   2842 H HG2  . LYS A 1 185 ? 48.25112 7.62573   18.21835 1.000 20.65284  ? 182 LYS A HG2  1 
ATOM   2843 H HG3  . LYS A 1 185 ? 47.41824 6.27620   18.32078 1.000 20.65284  ? 182 LYS A HG3  1 
ATOM   2844 H HD2  . LYS A 1 185 ? 48.75773 5.24291   16.76158 1.000 15.86431  ? 182 LYS A HD2  1 
ATOM   2845 H HD3  . LYS A 1 185 ? 49.45278 6.61712   16.36933 1.000 15.86431  ? 182 LYS A HD3  1 
ATOM   2846 H HE2  . LYS A 1 185 ? 50.56322 6.68224   18.40714 1.000 52.51849  ? 182 LYS A HE2  1 
ATOM   2847 H HE3  . LYS A 1 185 ? 49.79078 5.38406   18.90058 1.000 52.51849  ? 182 LYS A HE3  1 
ATOM   2848 H HZ1  . LYS A 1 185 ? 51.54946 5.28099   16.78597 1.000 75.51432  ? 182 LYS A HZ1  1 
ATOM   2849 H HZ2  . LYS A 1 185 ? 51.97520 4.95756   18.13225 1.000 75.51432  ? 182 LYS A HZ2  1 
ATOM   2850 H HZ3  . LYS A 1 185 ? 50.98875 4.13172   17.46650 1.000 75.51432  ? 182 LYS A HZ3  1 
ATOM   2851 N N    . ALA A 1 186 ? 46.64325 10.35209  17.73427 1.000 9.22228   ? 183 ALA A N    1 
ATOM   2852 C CA   . ALA A 1 186 ? 47.32943 11.26862  18.64001 1.000 15.26840  ? 183 ALA A CA   1 
ATOM   2853 C C    . ALA A 1 186 ? 46.45726 11.69986  19.82459 1.000 9.60827   ? 183 ALA A C    1 
ATOM   2854 O O    . ALA A 1 186 ? 46.94685 11.62571  20.96002 1.000 14.81907  ? 183 ALA A O    1 
ATOM   2855 C CB   . ALA A 1 186 ? 47.89183 12.47979  17.85819 1.000 12.78351  ? 183 ALA A CB   1 
ATOM   2856 H H    . ALA A 1 186 ? 46.56037 10.62475  16.92286 1.000 11.06676  ? 183 ALA A H    1 
ATOM   2857 H HA   . ALA A 1 186 ? 48.08925 10.79017  19.00697 1.000 18.32210  ? 183 ALA A HA   1 
ATOM   2858 H HB1  . ALA A 1 186 ? 48.26982 13.11391  18.48741 1.000 15.34023  ? 183 ALA A HB1  1 
ATOM   2859 H HB2  . ALA A 1 186 ? 48.57897 12.17006  17.24762 1.000 15.34023  ? 183 ALA A HB2  1 
ATOM   2860 H HB3  . ALA A 1 186 ? 47.17103 12.89695  17.36088 1.000 15.34023  ? 183 ALA A HB3  1 
ATOM   2861 N N    . PRO A 1 187 ? 45.19169 12.10862  19.67087 1.000 5.40345   ? 184 PRO A N    1 
ATOM   2862 C CA   . PRO A 1 187 ? 44.42180 12.53256  20.84605 1.000 4.43135   ? 184 PRO A CA   1 
ATOM   2863 C C    . PRO A 1 187 ? 44.03757 11.40213  21.79772 1.000 10.56989  ? 184 PRO A C    1 
ATOM   2864 O O    . PRO A 1 187 ? 43.32087 11.65638  22.76925 1.000 4.93639   ? 184 PRO A O    1 
ATOM   2865 C CB   . PRO A 1 187 ? 43.13389 13.16064  20.24732 1.000 7.93050   ? 184 PRO A CB   1 
ATOM   2866 C CG   . PRO A 1 187 ? 43.43853 13.43354  18.77723 1.000 12.29732  ? 184 PRO A CG   1 
ATOM   2867 C CD   . PRO A 1 187 ? 44.41068 12.29345  18.41913 1.000 4.70866   ? 184 PRO A CD   1 
ATOM   2868 H HA   . PRO A 1 187 ? 44.93042 13.20937  21.31948 1.000 5.31764   ? 184 PRO A HA   1 
ATOM   2869 H HB2  . PRO A 1 187 ? 42.39652 12.53647  20.33459 1.000 9.51661   ? 184 PRO A HB2  1 
ATOM   2870 H HB3  . PRO A 1 187 ? 42.92709 13.98571  20.71357 1.000 9.51661   ? 184 PRO A HB3  1 
ATOM   2871 H HG2  . PRO A 1 187 ? 42.62724 13.38850  18.24744 1.000 14.75680  ? 184 PRO A HG2  1 
ATOM   2872 H HG3  . PRO A 1 187 ? 43.85581 14.30282  18.67176 1.000 14.75680  ? 184 PRO A HG3  1 
ATOM   2873 H HD2  . PRO A 1 187 ? 43.92608 11.48463  18.19138 1.000 5.65041   ? 184 PRO A HD2  1 
ATOM   2874 H HD3  . PRO A 1 187 ? 44.99003 12.55092  17.68498 1.000 5.65041   ? 184 PRO A HD3  1 
ATOM   2875 N N    . LEU A 1 188 ? 44.38920 10.17614  21.49935 1.000 2.16240   ? 185 LEU A N    1 
ATOM   2876 C CA   . LEU A 1 188 ? 43.91186 9.06053   22.33146 1.000 5.34514   ? 185 LEU A CA   1 
ATOM   2877 C C    . LEU A 1 188 ? 44.79633 8.83039   23.53669 1.000 9.55854   ? 185 LEU A C    1 
ATOM   2878 O O    . LEU A 1 188 ? 44.40308 8.19719   24.52169 1.000 9.41223   ? 185 LEU A O    1 
ATOM   2879 C CB   . LEU A 1 188 ? 43.89301 7.81296   21.47419 1.000 9.47675   ? 185 LEU A CB   1 
ATOM   2880 C CG   . LEU A 1 188 ? 42.87558 7.77371   20.35146 1.000 6.54293   ? 185 LEU A CG   1 
ATOM   2881 C CD1  . LEU A 1 188 ? 43.14772 6.44628   19.68892 1.000 6.32650   ? 185 LEU A CD1  1 
ATOM   2882 C CD2  . LEU A 1 188 ? 41.50571 7.85321   20.91561 1.000 11.65101  ? 185 LEU A CD2  1 
ATOM   2883 H H    . LEU A 1 188 ? 44.89158 9.95145   20.83850 1.000 2.59490   ? 185 LEU A H    1 
ATOM   2884 H HA   . LEU A 1 188 ? 43.01559 9.24115   22.65545 1.000 6.41418   ? 185 LEU A HA   1 
ATOM   2885 H HB2  . LEU A 1 188 ? 44.76842 7.71523   21.06798 1.000 11.37211  ? 185 LEU A HB2  1 
ATOM   2886 H HB3  . LEU A 1 188 ? 43.70868 7.05549   22.05139 1.000 11.37211  ? 185 LEU A HB3  1 
ATOM   2887 H HG   . LEU A 1 188 ? 42.93496 8.50730   19.71962 1.000 7.85153   ? 185 LEU A HG   1 
ATOM   2888 H HD11 . LEU A 1 188 ? 42.52522 6.32624   18.95478 1.000 7.59181   ? 185 LEU A HD11 1 
ATOM   2889 H HD12 . LEU A 1 188 ? 44.05832 6.44094   19.35472 1.000 7.59181   ? 185 LEU A HD12 1 
ATOM   2890 H HD13 . LEU A 1 188 ? 43.03058 5.73790   20.34113 1.000 7.59181   ? 185 LEU A HD13 1 
ATOM   2891 H HD21 . LEU A 1 188 ? 40.86208 7.72466   20.20138 1.000 13.98123  ? 185 LEU A HD21 1 
ATOM   2892 H HD22 . LEU A 1 188 ? 41.39932 7.15980   21.58551 1.000 13.98123  ? 185 LEU A HD22 1 
ATOM   2893 H HD23 . LEU A 1 188 ? 41.38095 8.72594   21.32019 1.000 13.98123  ? 185 LEU A HD23 1 
ATOM   2894 N N    . VAL A 1 189 ? 46.00838 9.33307   23.43941 1.000 2.15620   ? 186 VAL A N    1 
ATOM   2895 C CA   . VAL A 1 189 ? 47.02911 9.20249   24.46590 1.000 6.55714   ? 186 VAL A CA   1 
ATOM   2896 C C    . VAL A 1 189 ? 47.37956 7.75326   24.65987 1.000 6.31141   ? 186 VAL A C    1 
ATOM   2897 O O    . VAL A 1 189 ? 47.35330 7.23614   25.79904 1.000 6.34679   ? 186 VAL A O    1 
ATOM   2898 C CB   . VAL A 1 189 ? 46.62692 9.82273   25.83239 1.000 5.45387   ? 186 VAL A CB   1 
ATOM   2899 C CG1  . VAL A 1 189 ? 47.94860 9.90628   26.66572 1.000 7.15930   ? 186 VAL A CG1  1 
ATOM   2900 C CG2  . VAL A 1 189 ? 45.95784 11.17364  25.64950 1.000 7.97063   ? 186 VAL A CG2  1 
ATOM   2901 H H    . VAL A 1 189 ? 46.28238 9.77729   22.75589 1.000 2.58746   ? 186 VAL A H    1 
ATOM   2902 H HA   . VAL A 1 189 ? 47.80233 9.68722   24.13718 1.000 7.86859   ? 186 VAL A HA   1 
ATOM   2903 H HB   . VAL A 1 189 ? 45.96840 9.28673   26.30138 1.000 6.54466   ? 186 VAL A HB   1 
ATOM   2904 H HG11 . VAL A 1 189 ? 47.76352 10.35112  27.50761 1.000 8.59117   ? 186 VAL A HG11 1 
ATOM   2905 H HG12 . VAL A 1 189 ? 48.27503 9.00794   26.83103 1.000 8.59117   ? 186 VAL A HG12 1 
ATOM   2906 H HG13 . VAL A 1 189 ? 48.60750 10.41039  26.16310 1.000 8.59117   ? 186 VAL A HG13 1 
ATOM   2907 H HG21 . VAL A 1 189 ? 45.80861 11.57270  26.52092 1.000 9.56477   ? 186 VAL A HG21 1 
ATOM   2908 H HG22 . VAL A 1 189 ? 46.53672 11.74358  25.11943 1.000 9.56477   ? 186 VAL A HG22 1 
ATOM   2909 H HG23 . VAL A 1 189 ? 45.11077 11.04743  25.19404 1.000 9.56477   ? 186 VAL A HG23 1 
ATOM   2910 N N    . LEU A 1 190 ? 47.67738 7.06793   23.55064 1.000 8.08975   ? 187 LEU A N    1 
ATOM   2911 C CA   . LEU A 1 190 ? 48.28175 5.73816   23.56733 1.000 12.80815  ? 187 LEU A CA   1 
ATOM   2912 C C    . LEU A 1 190 ? 49.78865 5.81775   23.86308 1.000 19.49824  ? 187 LEU A C    1 
ATOM   2913 O O    . LEU A 1 190 ? 50.45439 6.81463   23.58757 1.000 23.67559  ? 187 LEU A O    1 
ATOM   2914 C CB   . LEU A 1 190 ? 48.05847 5.05354   22.20376 1.000 10.64380  ? 187 LEU A CB   1 
ATOM   2915 C CG   . LEU A 1 190 ? 46.59048 4.71257   22.00847 1.000 11.79636  ? 187 LEU A CG   1 
ATOM   2916 C CD1  . LEU A 1 190 ? 46.38387 4.31764   20.59570 1.000 15.47567  ? 187 LEU A CD1  1 
ATOM   2917 C CD2  . LEU A 1 190 ? 46.24498 3.58787   22.92582 1.000 20.93520  ? 187 LEU A CD2  1 
ATOM   2918 H H    . LEU A 1 190 ? 47.53418 7.36172   22.75516 1.000 9.70772   ? 187 LEU A H    1 
ATOM   2919 H HA   . LEU A 1 190 ? 47.87080 5.20478   24.26557 1.000 15.36979  ? 187 LEU A HA   1 
ATOM   2920 H HB2  . LEU A 1 190 ? 48.33460 5.65250   21.49249 1.000 12.77258  ? 187 LEU A HB2  1 
ATOM   2921 H HB3  . LEU A 1 190 ? 48.57470 4.23319   22.16578 1.000 12.77258  ? 187 LEU A HB3  1 
ATOM   2922 H HG   . LEU A 1 190 ? 46.01510 5.46776   22.20729 1.000 14.15565  ? 187 LEU A HG   1 
ATOM   2923 H HD11 . LEU A 1 190 ? 45.47896 3.98468   20.48997 1.000 18.57082  ? 187 LEU A HD11 1 
ATOM   2924 H HD12 . LEU A 1 190 ? 46.51968 5.09243   20.02811 1.000 18.57082  ? 187 LEU A HD12 1 
ATOM   2925 H HD13 . LEU A 1 190 ? 47.02084 3.62325   20.36551 1.000 18.57082  ? 187 LEU A HD13 1 
ATOM   2926 H HD21 . LEU A 1 190 ? 45.36244 3.25522   22.69919 1.000 25.12226  ? 187 LEU A HD21 1 
ATOM   2927 H HD22 . LEU A 1 190 ? 46.90165 2.88169   22.82094 1.000 25.12226  ? 187 LEU A HD22 1 
ATOM   2928 H HD23 . LEU A 1 190 ? 46.25147 3.91249   23.83987 1.000 25.12226  ? 187 LEU A HD23 1 
ATOM   2929 N N    . LYS A 1 191 ? 50.31436 4.73599   24.45953 1.000 26.65165  ? 188 LYS A N    1 
ATOM   2930 C CA   A LYS A 1 191 ? 51.74576 4.65464   24.75288 0.368 38.50975  ? 188 LYS A CA   1 
ATOM   2931 C CA   B LYS A 1 191 ? 51.74680 4.65449   24.75444 0.632 38.53969  ? 188 LYS A CA   1 
ATOM   2932 C C    . LYS A 1 191 ? 52.55910 4.55233   23.46103 1.000 54.45368  ? 188 LYS A C    1 
ATOM   2933 O O    . LYS A 1 191 ? 53.38357 5.43431   23.15207 1.000 54.49312  ? 188 LYS A O    1 
ATOM   2934 C CB   A LYS A 1 191 ? 52.00989 3.46342   25.68871 0.368 42.02884  ? 188 LYS A CB   1 
ATOM   2935 C CB   B LYS A 1 191 ? 52.01195 3.46720   25.69994 0.632 42.06522  ? 188 LYS A CB   1 
ATOM   2936 C CG   A LYS A 1 191 ? 53.41558 3.40050   26.30879 0.368 49.88377  ? 188 LYS A CG   1 
ATOM   2937 C CG   B LYS A 1 191 ? 53.37019 3.49456   26.42040 0.632 50.12636  ? 188 LYS A CG   1 
ATOM   2938 C CD   A LYS A 1 191 ? 53.53563 4.20847   27.60800 0.368 40.64308  ? 188 LYS A CD   1 
ATOM   2939 C CD   B LYS A 1 191 ? 53.30565 2.88539   27.81674 0.632 43.27493  ? 188 LYS A CD   1 
ATOM   2940 C CE   A LYS A 1 191 ? 54.99197 4.35947   28.05495 0.368 37.94718  ? 188 LYS A CE   1 
ATOM   2941 C CE   B LYS A 1 191 ? 53.88384 1.48008   27.85304 0.632 56.58332  ? 188 LYS A CE   1 
ATOM   2942 N NZ   A LYS A 1 191 ? 55.13247 5.34871   29.16670 0.368 40.88116  ? 188 LYS A NZ   1 
ATOM   2943 N NZ   B LYS A 1 191 ? 54.76687 1.31963   29.04826 0.632 45.21067  ? 188 LYS A NZ   1 
ATOM   2944 H H    A LYS A 1 191 ? 49.86463 4.04381   24.70084 0.368 31.98199  ? 188 LYS A H    1 
ATOM   2945 H H    B LYS A 1 191 ? 49.86461 4.04360   24.70020 0.632 31.98199  ? 188 LYS A H    1 
ATOM   2946 H HA   A LYS A 1 191 ? 52.03201 5.45924   25.21286 0.368 46.21171  ? 188 LYS A HA   1 
ATOM   2947 H HA   B LYS A 1 191 ? 52.03505 5.45905   25.21324 0.632 46.24765  ? 188 LYS A HA   1 
ATOM   2948 H HB2  A LYS A 1 191 ? 51.37432 3.50468   26.42032 0.368 50.43463  ? 188 LYS A HB2  1 
ATOM   2949 H HB2  B LYS A 1 191 ? 51.32214 3.45886   26.38185 0.632 50.47828  ? 188 LYS A HB2  1 
ATOM   2950 H HB3  A LYS A 1 191 ? 51.88148 2.64543   25.18344 0.368 50.43463  ? 188 LYS A HB3  1 
ATOM   2951 H HB3  B LYS A 1 191 ? 51.97541 2.64848   25.18104 0.632 50.47828  ? 188 LYS A HB3  1 
ATOM   2952 H HG2  A LYS A 1 191 ? 53.62992 2.47641   26.51128 0.368 59.86054  ? 188 LYS A HG2  1 
ATOM   2953 H HG2  B LYS A 1 191 ? 54.01456 2.98815   25.90151 0.632 60.15165  ? 188 LYS A HG2  1 
ATOM   2954 H HG3  A LYS A 1 191 ? 54.05637 3.75841   25.67461 0.368 59.86054  ? 188 LYS A HG3  1 
ATOM   2955 H HG3  B LYS A 1 191 ? 53.66428 4.41477   26.50771 0.632 60.15165  ? 188 LYS A HG3  1 
ATOM   2956 H HD2  A LYS A 1 191 ? 53.16811 5.09518   27.46811 0.368 48.77172  ? 188 LYS A HD2  1 
ATOM   2957 H HD2  B LYS A 1 191 ? 53.81489 3.43805   28.43004 0.632 51.92994  ? 188 LYS A HD2  1 
ATOM   2958 H HD3  A LYS A 1 191 ? 53.04783 3.75457   28.31294 0.368 48.77172  ? 188 LYS A HD3  1 
ATOM   2959 H HD3  B LYS A 1 191 ? 52.37983 2.83916   28.10243 0.632 51.92994  ? 188 LYS A HD3  1 
ATOM   2960 H HE2  A LYS A 1 191 ? 55.32105 3.50231   28.36781 0.368 45.53663  ? 188 LYS A HE2  1 
ATOM   2961 H HE2  B LYS A 1 191 ? 53.16412 0.83216   27.90879 0.632 67.90000  ? 188 LYS A HE2  1 
ATOM   2962 H HE3  A LYS A 1 191 ? 55.52624 4.66661   27.30587 0.368 45.53663  ? 188 LYS A HE3  1 
ATOM   2963 H HE3  B LYS A 1 191 ? 54.41055 1.32290   27.05381 0.632 67.90000  ? 188 LYS A HE3  1 
ATOM   2964 H HZ1  A LYS A 1 191 ? 55.98835 5.42750   29.39770 0.368 49.05741  ? 188 LYS A HZ1  1 
ATOM   2965 H HZ1  B LYS A 1 191 ? 55.09794 0.49388   29.07347 0.632 54.25282  ? 188 LYS A HZ1  1 
ATOM   2966 H HZ2  A LYS A 1 191 ? 54.82909 6.14398   28.90667 0.368 49.05741  ? 188 LYS A HZ2  1 
ATOM   2967 H HZ2  B LYS A 1 191 ? 55.44059 1.89986   29.00907 0.632 54.25282  ? 188 LYS A HZ2  1 
ATOM   2968 H HZ3  A LYS A 1 191 ? 54.66580 5.07902   29.87492 0.368 49.05741  ? 188 LYS A HZ3  1 
ATOM   2969 H HZ3  B LYS A 1 191 ? 54.30158 1.46711   29.79248 0.632 54.25282  ? 188 LYS A HZ3  1 
ATOM   2970 N N    . ASP A 1 192 ? 52.30481 3.51057   22.66105 1.000 43.13990  ? 189 ASP A N    1 
ATOM   2971 C CA   . ASP A 1 192 ? 53.06769 3.29868   21.42099 1.000 69.78908  ? 189 ASP A CA   1 
ATOM   2972 C C    . ASP A 1 192 ? 52.14682 3.19485   20.21986 1.000 57.98111  ? 189 ASP A C    1 
ATOM   2973 O O    . ASP A 1 192 ? 52.19772 4.07476   19.37052 1.000 52.71126  ? 189 ASP A O    1 
ATOM   2974 C CB   . ASP A 1 192 ? 53.94386 2.04132   21.55367 1.000 64.12156  ? 189 ASP A CB   1 
ATOM   2975 C CG   . ASP A 1 192 ? 54.98727 2.17788   22.68205 1.000 76.12663  ? 189 ASP A CG   1 
ATOM   2976 O OD1  . ASP A 1 192 ? 55.65757 3.25414   22.73601 1.000 75.33504  ? 189 ASP A OD1  1 
ATOM   2977 O OD2  . ASP A 1 192 ? 55.09373 1.22512   23.51315 1.000 75.26192  ? 189 ASP A OD2  1 
ATOM   2978 H H    . ASP A 1 192 ? 51.70127 2.91667   22.81146 1.000 51.76790  ? 189 ASP A H    1 
ATOM   2979 H HA   . ASP A 1 192 ? 53.65322 4.05636   21.26615 1.000 83.74692  ? 189 ASP A HA   1 
ATOM   2980 H HB2  . ASP A 1 192 ? 53.37881 1.27887   21.75441 1.000 76.94588  ? 189 ASP A HB2  1 
ATOM   2981 H HB3  . ASP A 1 192 ? 54.41707 1.89320   20.71998 1.000 76.94588  ? 189 ASP A HB3  1 
HETATM 2982 O O    . 4Y8 B 2 .   ? 37.23093 -13.89868 23.28410 0.885 38.53980  ? 201 4Y8 A O    1 
HETATM 2983 C C    . 4Y8 B 2 .   ? 38.10174 -13.63613 24.10173 0.885 33.97858  ? 201 4Y8 A C    1 
HETATM 2984 C CM2  . 4Y8 B 2 .   ? 38.62110 -14.47501 25.26918 0.885 36.09155  ? 201 4Y8 A CM2  1 
HETATM 2985 C CM1  . 4Y8 B 2 .   ? 38.55800 -12.40532 23.75494 0.885 3.93483   ? 201 4Y8 A CM1  1 
HETATM 2986 O O1   . 4Y8 B 2 .   ? 37.51280 -12.01261 23.46886 0.885 18.15876  ? 201 4Y8 A O1   1 
HETATM 2987 H H1   . 4Y8 B 2 .   ? 38.15453 -15.46156 25.30807 0.885 43.30988  ? 201 4Y8 A H1   1 
HETATM 2988 H H2   . 4Y8 B 2 .   ? 38.43062 -14.00136 26.23449 0.885 43.30988  ? 201 4Y8 A H2   1 
HETATM 2989 H H3   . 4Y8 B 2 .   ? 39.69874 -14.64146 25.21038 0.885 43.30988  ? 201 4Y8 A H3   1 
HETATM 2990 H H5   . 4Y8 B 2 .   ? 39.13053 -11.84047 24.53584 0.885 4.72181   ? 201 4Y8 A H5   1 
HETATM 2991 H H6   . 4Y8 B 2 .   ? 37.49682 -12.31602 22.50288 0.885 21.79052  ? 201 4Y8 A H6   1 
HETATM 2992 O O    . HOH C 3 .   ? 30.37919 -6.30115  2.66133  1.000 34.15720  ? 301 HOH A O    1 
HETATM 2993 O O    . HOH C 3 .   ? 52.48571 -20.09947 19.15161 1.000 40.94404  ? 302 HOH A O    1 
HETATM 2994 O O    . HOH C 3 .   ? 50.12472 -17.96469 21.54393 1.000 16.15518  ? 303 HOH A O    1 
HETATM 2995 O O    . HOH C 3 .   ? 14.66354 -5.98126  11.31194 1.000 31.56700  ? 304 HOH A O    1 
HETATM 2996 O O    . HOH C 3 .   ? 51.55044 9.00911   23.93255 1.000 40.46875  ? 305 HOH A O    1 
HETATM 2997 O O    . HOH C 3 .   ? 33.74580 -19.93930 17.74593 1.000 25.85787  ? 306 HOH A O    1 
HETATM 2998 O O    . HOH C 3 .   ? 24.30271 0.18168   7.31828  1.000 28.73401  ? 307 HOH A O    1 
HETATM 2999 O O    . HOH C 3 .   ? 16.93333 -2.36123  12.08120 1.000 21.24438  ? 308 HOH A O    1 
HETATM 3000 O O    . HOH C 3 .   ? 51.07762 -11.83968 4.45709  1.000 36.04846  ? 309 HOH A O    1 
HETATM 3001 O O    . HOH C 3 .   ? 44.12962 -13.76320 3.09147  1.000 35.81449  ? 310 HOH A O    1 
HETATM 3002 O O    . HOH C 3 .   ? 45.59832 14.58988  15.37417 1.000 13.62010  ? 311 HOH A O    1 
HETATM 3003 O O    . HOH C 3 .   ? 39.25336 -29.35094 9.35341  1.000 35.15545  ? 312 HOH A O    1 
HETATM 3004 O O    . HOH C 3 .   ? 31.16109 -25.19533 10.31933 1.000 39.09809  ? 313 HOH A O    1 
HETATM 3005 O O    . HOH C 3 .   ? 45.73365 -1.78958  21.68996 1.000 11.33963  ? 314 HOH A O    1 
HETATM 3006 O O    . HOH C 3 .   ? 26.95336 -8.26937  36.47123 1.000 38.92497  ? 315 HOH A O    1 
HETATM 3007 O O    . HOH C 3 .   ? 34.36259 2.22528   -0.53916 1.000 44.34662  ? 316 HOH A O    1 
HETATM 3008 O O    . HOH C 3 .   ? 45.55049 8.67117   5.25990  1.000 20.54847  ? 317 HOH A O    1 
HETATM 3009 O O    . HOH C 3 .   ? 45.26218 -12.24268 9.89383  1.000 7.36496   ? 318 HOH A O    1 
HETATM 3010 O O    . HOH C 3 .   ? 34.68148 -21.95812 15.26800 1.000 26.30211  ? 319 HOH A O    1 
HETATM 3011 O O    . HOH C 3 .   ? 23.52837 -19.39996 18.67529 1.000 51.23066  ? 320 HOH A O    1 
HETATM 3012 O O    . HOH C 3 .   ? 46.322   -28.316   14.335   1.000 12.94678  ? 321 HOH A O    1 
HETATM 3013 O O    . HOH C 3 .   ? 44.05996 -27.91606 17.28433 1.000 17.93819  ? 322 HOH A O    1 
HETATM 3014 O O    . HOH C 3 .   ? 19.82586 -7.85275  19.54584 1.000 26.28119  ? 323 HOH A O    1 
HETATM 3015 O O    . HOH C 3 .   ? 25.29414 1.50019   20.09324 1.000 13.76193  ? 324 HOH A O    1 
HETATM 3016 O O    . HOH C 3 .   ? 53.44729 -10.78755 20.27740 1.000 55.87566  ? 325 HOH A O    1 
HETATM 3017 O O    . HOH C 3 .   ? 41.54108 -23.25905 22.11684 1.000 23.40957  ? 326 HOH A O    1 
HETATM 3018 O O    . HOH C 3 .   ? 26.04548 2.93133   17.80481 1.000 10.47940  ? 327 HOH A O    1 
HETATM 3019 O O    . HOH C 3 .   ? 48.21264 8.78960   21.20968 1.000 13.45769  ? 328 HOH A O    1 
HETATM 3020 O O    . HOH C 3 .   ? 25.82497 -12.23418 27.89439 1.000 18.05836  ? 329 HOH A O    1 
HETATM 3021 O O    . HOH C 3 .   ? 41.75332 -18.19973 1.06749  1.000 31.89471  ? 330 HOH A O    1 
HETATM 3022 O O    . HOH C 3 .   ? 31.11527 1.83333   1.11281  1.000 40.89126  ? 331 HOH A O    1 
HETATM 3023 O O    . HOH C 3 .   ? 38.54133 -27.80257 11.25443 1.000 25.46294  ? 332 HOH A O    1 
HETATM 3024 O O    . HOH C 3 .   ? 49.99553 9.87841   15.87628 1.000 24.79613  ? 333 HOH A O    1 
HETATM 3025 O O    . HOH C 3 .   ? 34.624   -11.183   33.919   1.000 12.55316  ? 334 HOH A O    1 
HETATM 3026 O O    . HOH C 3 .   ? 47.41076 -25.40236 18.36068 1.000 20.21594  ? 335 HOH A O    1 
HETATM 3027 O O    . HOH C 3 .   ? 38.28811 -20.57051 2.59862  1.000 13.97057  ? 336 HOH A O    1 
HETATM 3028 O O    . HOH C 3 .   ? 54.42870 -15.32637 15.21904 1.000 24.45359  ? 337 HOH A O    1 
HETATM 3029 O O    . HOH C 3 .   ? 48.78840 -11.74974 1.31228  1.000 32.74975  ? 338 HOH A O    1 
HETATM 3030 O O    . HOH C 3 .   ? 37.61418 -2.98885  1.62277  1.000 25.14381  ? 339 HOH A O    1 
HETATM 3031 O O    . HOH C 3 .   ? 27.60111 1.76842   7.76699  1.000 22.24472  ? 340 HOH A O    1 
HETATM 3032 O O    . HOH C 3 .   ? 42.40168 -24.85390 11.04664 1.000 5.52783   ? 341 HOH A O    1 
HETATM 3033 O O    . HOH C 3 .   ? 29.49929 -10.18271 18.39484 1.000 3.95502   ? 342 HOH A O    1 
HETATM 3034 O O    . HOH C 3 .   ? 46.309   -29.931   7.595    1.000 9.46028   ? 343 HOH A O    1 
HETATM 3035 O O    . HOH C 3 .   ? 37.79827 -26.02318 15.94826 1.000 25.38869  ? 344 HOH A O    1 
HETATM 3036 O O    . HOH C 3 .   ? 29.11017 -8.98749  2.97118  1.000 28.29835  ? 345 HOH A O    1 
HETATM 3037 O O    . HOH C 3 .   ? 46.36409 1.85214   3.33932  1.000 30.05073  ? 346 HOH A O    1 
HETATM 3038 O O    . HOH C 3 .   ? 21.68404 -15.37627 12.97124 1.000 31.11256  ? 347 HOH A O    1 
HETATM 3039 O O    . HOH C 3 .   ? 31.59207 -14.55303 26.24374 1.000 13.60444  ? 348 HOH A O    1 
HETATM 3040 O O    . HOH C 3 .   ? 38.96729 -17.44633 26.83293 1.000 28.24654  ? 349 HOH A O    1 
HETATM 3041 O O    . HOH C 3 .   ? 48.55164 4.91162   3.72317  1.000 36.91643  ? 350 HOH A O    1 
HETATM 3042 O O    . HOH C 3 .   ? 41.71469 2.12227   1.07851  1.000 53.13550  ? 351 HOH A O    1 
HETATM 3043 O O    . HOH C 3 .   ? 51.21924 -11.66069 21.67628 1.000 28.97716  ? 352 HOH A O    1 
HETATM 3044 O O    . HOH C 3 .   ? 34.10347 -19.35465 21.02173 1.000 34.09547  ? 353 HOH A O    1 
HETATM 3045 O O    . HOH C 3 .   ? 55.48115 -12.95173 15.83398 1.000 49.78504  ? 354 HOH A O    1 
HETATM 3046 O O    . HOH C 3 .   ? 22.01583 -9.93303  18.89666 1.000 21.93952  ? 355 HOH A O    1 
HETATM 3047 O O    . HOH C 3 .   ? 21.64221 -19.57282 11.82535 1.000 33.92687  ? 356 HOH A O    1 
HETATM 3048 O O    . HOH C 3 .   ? 20.00722 -13.45613 12.42149 1.000 41.83575  ? 357 HOH A O    1 
HETATM 3049 O O    . HOH C 3 .   ? 31.49477 -11.85787 19.24591 1.000 6.00611   ? 358 HOH A O    1 
HETATM 3050 O O    . HOH C 3 .   ? 51.19453 -11.65128 7.07567  1.000 25.25881  ? 359 HOH A O    1 
HETATM 3051 O O    . HOH C 3 .   ? 30.84168 -23.59710 6.55881  1.000 35.56214  ? 360 HOH A O    1 
HETATM 3052 O O    . HOH C 3 .   ? 39.22070 -18.36390 24.06483 1.000 46.68009  ? 361 HOH A O    1 
HETATM 3053 O O    . HOH C 3 .   ? 28.87218 6.01635   12.13508 1.000 9.60468   ? 362 HOH A O    1 
HETATM 3054 O O    . HOH C 3 .   ? 23.28487 -6.52028  32.35811 1.000 21.93909  ? 363 HOH A O    1 
HETATM 3055 O O    . HOH C 3 .   ? 44.38242 -30.17362 14.07829 1.000 10.89781  ? 364 HOH A O    1 
HETATM 3056 O O    . HOH C 3 .   ? 51.00137 -22.42219 12.14719 1.000 12.87621  ? 365 HOH A O    1 
HETATM 3057 O O    . HOH C 3 .   ? 44.68236 -22.70176 22.69094 1.000 15.23037  ? 366 HOH A O    1 
HETATM 3058 O O    . HOH C 3 .   ? 23.64986 -17.77530 16.35195 1.000 27.55339  ? 367 HOH A O    1 
HETATM 3059 O O    . HOH C 3 .   ? 46.41336 -2.13642  8.20883  1.000 21.52330  ? 368 HOH A O    1 
HETATM 3060 O O    . HOH C 3 .   ? 21.22679 -9.99572  24.94012 1.000 22.42211  ? 369 HOH A O    1 
HETATM 3061 O O    . HOH C 3 .   ? 18.02205 -0.44324  19.03188 1.000 41.36851  ? 370 HOH A O    1 
HETATM 3062 O O    . HOH C 3 .   ? 44.76970 -24.22926 4.09275  1.000 11.20694  ? 371 HOH A O    1 
HETATM 3063 O O    . HOH C 3 .   ? 35.15046 -25.63019 9.04418  1.000 33.36687  ? 372 HOH A O    1 
HETATM 3064 O O    . HOH C 3 .   ? 45.80669 -1.23609  24.81692 1.000 35.64920  ? 373 HOH A O    1 
HETATM 3065 O O    . HOH C 3 .   ? 22.78056 -12.65695 19.84677 1.000 17.50359  ? 374 HOH A O    1 
HETATM 3066 O O    . HOH C 3 .   ? 33.79167 -10.95041 -7.36123 1.000 35.23807  ? 375 HOH A O    1 
HETATM 3067 O O    . HOH C 3 .   ? 18.79960 3.31135   15.02005 1.000 45.44712  ? 376 HOH A O    1 
HETATM 3068 O O    . HOH C 3 .   ? 22.30237 2.73581   18.66481 1.000 31.08718  ? 377 HOH A O    1 
HETATM 3069 O O    . HOH C 3 .   ? 50.54153 -4.08542  16.87630 1.000 24.85047  ? 378 HOH A O    1 
HETATM 3070 O O    . HOH C 3 .   ? 53.43030 -8.02238  17.58838 1.000 19.23948  ? 379 HOH A O    1 
HETATM 3071 O O    . HOH C 3 .   ? 25.26297 -20.72943 20.94462 1.000 36.97171  ? 380 HOH A O    1 
HETATM 3072 O O    . HOH C 3 .   ? 48.37329 8.44977   3.99572  1.000 45.21549  ? 381 HOH A O    1 
HETATM 3073 O O    . HOH C 3 .   ? 48.52000 -20.64204 22.92244 1.000 25.55493  ? 382 HOH A O    1 
HETATM 3074 O O    . HOH C 3 .   ? 42.98808 -12.68678 1.09471  1.000 46.76005  ? 383 HOH A O    1 
HETATM 3075 O O    . HOH C 3 .   ? 29.02269 -23.33887 11.14933 1.000 36.20560  ? 384 HOH A O    1 
HETATM 3076 O O    . HOH C 3 .   ? 23.98691 -19.19439 4.70310  1.000 38.53779  ? 385 HOH A O    1 
HETATM 3077 O O    . HOH C 3 .   ? 40.75476 -15.38394 1.17833  1.000 40.70745  ? 386 HOH A O    1 
HETATM 3078 O O    . HOH C 3 .   ? 36.41081 -27.53981 6.65098  1.000 52.26805  ? 387 HOH A O    1 
HETATM 3079 O O    . HOH C 3 .   ? 37.85538 12.32600  23.69763 1.000 24.46104  ? 388 HOH A O    1 
HETATM 3080 O O    . HOH C 3 .   ? 42.96673 -25.90120 3.60974  1.000 20.57589  ? 389 HOH A O    1 
HETATM 3081 O O    . HOH C 3 .   ? 36.92558 -3.94947  -1.03782 1.000 44.93235  ? 390 HOH A O    1 
HETATM 3082 O O    . HOH C 3 .   ? 42.85218 4.51168   1.06917  1.000 44.71626  ? 391 HOH A O    1 
HETATM 3083 O O    . HOH C 3 .   ? 30.77336 -5.22998  -4.84343 1.000 38.13444  ? 392 HOH A O    1 
HETATM 3084 O O    . HOH C 3 .   ? 18.83111 -9.88045  12.54374 1.000 26.24142  ? 393 HOH A O    1 
HETATM 3085 O O    . HOH C 3 .   ? 13.87778 -10.02683 16.38174 1.000 41.23580  ? 394 HOH A O    1 
HETATM 3086 O O    . HOH C 3 .   ? 39.98487 12.65473  22.56137 1.000 28.94406  ? 395 HOH A O    1 
HETATM 3087 O O    . HOH C 3 .   ? 17.00723 0.32044   12.79568 1.000 34.07937  ? 396 HOH A O    1 
HETATM 3088 O O    . HOH C 3 .   ? 33.871   -22.082   -0.752   1.000 59.52603  ? 397 HOH A O    1 
HETATM 3089 O O    . HOH C 3 .   ? 38.36718 -27.70955 17.76971 1.000 41.29704  ? 398 HOH A O    1 
HETATM 3090 O O    . HOH C 3 .   ? 35.093   -14.069   26.833   1.000 5.19497   ? 399 HOH A O    1 
HETATM 3091 O O    . HOH C 3 .   ? 51.61540 -6.41992  15.41547 1.000 25.57753  ? 400 HOH A O    1 
HETATM 3092 O O    . HOH C 3 .   ? 38.822   11.594    8.334    1.000 26.11844  ? 401 HOH A O    1 
HETATM 3093 O O    . HOH C 3 .   ? 50.00345 13.44089  14.80304 1.000 45.64598  ? 402 HOH A O    1 
HETATM 3094 O O    . HOH C 3 .   ? 19.51143 2.62608   18.67389 1.000 44.88052  ? 403 HOH A O    1 
HETATM 3095 O O    . HOH C 3 .   ? 47.90501 -0.28416  13.87781 1.000 41.60661  ? 404 HOH A O    1 
HETATM 3096 O O    . HOH C 3 .   ? 48.22591 -2.33320  25.38377 1.000 34.83703  ? 405 HOH A O    1 
HETATM 3097 O O    . HOH C 3 .   ? 35.50873 7.53369   5.25600  1.000 39.23696  ? 406 HOH A O    1 
HETATM 3098 O O    . HOH C 3 .   ? 41.15226 -28.67701 18.04011 1.000 45.87699  ? 407 HOH A O    1 
HETATM 3099 O O    . HOH C 3 .   ? 26.92646 -15.77643 0.26608  1.000 40.10457  ? 408 HOH A O    1 
HETATM 3100 O O    . HOH C 3 .   ? 52.04251 -9.39357  23.17587 1.000 30.66217  ? 409 HOH A O    1 
HETATM 3101 O O    . HOH C 3 .   ? 25.15858 -16.39109 24.74248 1.000 29.63692  ? 410 HOH A O    1 
HETATM 3102 O O    . HOH C 3 .   ? 36.52920 -27.31490 13.54896 1.000 44.36607  ? 411 HOH A O    1 
HETATM 3103 O O    . HOH C 3 .   ? 49.95561 3.18747   14.92221 1.000 34.14899  ? 412 HOH A O    1 
HETATM 3104 O O    . HOH C 3 .   ? 47.50572 0.18932   22.61362 1.000 37.35507  ? 413 HOH A O    1 
HETATM 3105 O O    . HOH C 3 .   ? 50.03586 10.59811  22.24324 1.000 49.63915  ? 414 HOH A O    1 
HETATM 3106 O O    . HOH C 3 .   ? 47.20794 -0.64196  5.99608  1.000 47.97559  ? 415 HOH A O    1 
HETATM 3107 O O    . HOH C 3 .   ? 19.03130 -9.50447  21.64351 1.000 42.68605  ? 416 HOH A O    1 
HETATM 3108 O O    . HOH C 3 .   ? 52.42431 8.42687   17.46766 1.000 49.98498  ? 417 HOH A O    1 
HETATM 3109 O O    . HOH C 3 .   ? 38.79951 -20.59115 27.01195 1.000 40.51420  ? 418 HOH A O    1 
HETATM 3110 O O    . HOH C 3 .   ? 22.26887 -15.02465 18.62839 1.000 37.73004  ? 419 HOH A O    1 
HETATM 3111 O O    . HOH C 3 .   ? 51.28472 1.45732   13.18886 1.000 47.63687  ? 420 HOH A O    1 
HETATM 3112 O O    . HOH C 3 .   ? 52.28960 14.88135  13.57199 1.000 44.03563  ? 421 HOH A O    1 
HETATM 3113 O O    . HOH C 3 .   ? 49.63112 -2.04721  14.71028 1.000 46.10536  ? 422 HOH A O    1 
HETATM 3114 O O    . HOH C 3 .   ? 50.67458 9.10421   18.86046 1.000 39.57589  ? 423 HOH A O    1 
HETATM 3115 O O    . HOH C 3 .   ? 27.15102 -18.18986 0.75033  1.000 44.07023  ? 424 HOH A O    1 
HETATM 3116 O O    . HOH C 3 .   ? 49.48586 -2.92342  12.66657 1.000 41.48202  ? 425 HOH A O    1 
HETATM 3117 O O    . HOH C 3 .   ? 52.14789 -0.32143  13.54672 1.000 58.86466  ? 426 HOH A O    1 
HETATM 3118 O O    . HOH C 3 .   ? 54.16461 10.29231  17.52392 1.000 52.37426  ? 427 HOH A O    1 
# 
