data_9CAX
# 
_entry.id   9CAX 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9CAX         pdb_00009cax 10.2210/pdb9cax/pdb 
WWPDB D_1000285127 ?            ?                   
EMDB  EMD-45406    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1  'Structure model' 1 0 2025-01-29 ? 
2  'EM metadata'     1 0 2025-01-29 ? 
3  'Additional map'  1 0 2025-01-29 ? 
4  FSC               1 0 2025-01-29 ? 
5  'Half map'        1 0 2025-01-29 1 
6  'Half map'        1 0 2025-01-29 2 
7  Image             1 0 2025-01-29 ? 
8  Mask              1 0 2025-01-29 ? 
9  'Primary map'     1 0 2025-01-29 ? 
10 'Structure model' 1 1 2025-05-28 ? 
11 'EM metadata'     1 1 2025-05-28 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 FSC               repository 'Initial release' ? ? 
5 5 'Half map'        repository 'Initial release' ? ? 
6 6 'Half map'        repository 'Initial release' ? ? 
7 7 Image             repository 'Initial release' ? ? 
8 8 Mask              repository 'Initial release' ? ? 
9 9 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 10 'Structure model' 'Data collection'      
2 11 'EM metadata'     'Data processing'      
3 11 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 10 'Structure model' em_admin    
2 10 'Structure model' em_software 
3 11 'EM metadata'     em_admin    
4 11 'EM metadata'     em_software 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 10 'Structure model' '_em_admin.last_update' 
2 10 'Structure model' '_em_software.name'     
3 11 'EM metadata'     '_em_admin.last_update' 
4 11 'EM metadata'     '_em_software.name'     
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9CAX 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-18 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Structure of human SLC2A9 transporter' 
_pdbx_database_related.db_id          EMD-45406 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              stroud@msg.ucsf.edu 
_pdbx_contact_author.name_first         Robert 
_pdbx_contact_author.name_last          Stroud 
_pdbx_contact_author.name_mi            M. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2083-5665 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Khandelwal, N.K.' 1 0000-0002-6319-8048 
'Gupta, M.'        2 0000-0002-7432-3211 
'Stroud, R.M.'     3 0000-0003-2083-5665 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            0353 
_citation.journal_id_ISSN           ? 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     'Structure of human SLC2A9' 
_citation.year                      ? 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Khandelwal, N.K.' 1 ? 
primary 'Stroud, R.M.'     2 ? 
primary 'Gupta, M.G.'      3 ? 
# 
_entity.id                         1 
_entity.type                       polymer 
_entity.src_method                 man 
_entity.pdbx_description           'Soluble cytochrome b562,Solute carrier family 2, facilitated glucose transporter member 9' 
_entity.formula_weight             69859.695 
_entity.pdbx_number_of_molecules   1 
_entity.pdbx_ec                    ? 
_entity.pdbx_mutation              ? 
_entity.pdbx_fragment              ? 
_entity.details                    
;N-terminal Flag tag, HRV3C site followed by BRIL tag N-terminal truncated SlC2A9 isoform 1 (residue 52-540 as per uniprot). C terminal thrombin site followed by 10X his tag,N-terminal Flag tag, HRV3C site followed by BRIL tag N-terminal truncated SlC2A9 isoform 1 (residue 52-540 as per uniprot). C terminal thrombin site followed by 10X his tag,N-terminal Flag tag, HRV3C site followed by BRIL tag N-terminal truncated SlC2A9 isoform 1 (residue 52-540 as per uniprot). C terminal thrombin site followed by 10X his tag,N-terminal Flag tag, HRV3C site followed by BRIL tag N-terminal truncated SlC2A9 isoform 1 (residue 52-540 as per uniprot). C terminal thrombin site followed by 10X his tag,N-terminal Flag tag, HRV3C site followed by BRIL tag N-terminal truncated SlC2A9 isoform 1 (residue 52-540 as per uniprot). C terminal thrombin site followed by 10X his tag,N-terminal Flag tag, HRV3C site followed by BRIL tag N-terminal truncated SlC2A9 isoform 1 (residue 52-540 as per uniprot). C terminal thrombin site followed by 10X his tag,N-terminal Flag tag, HRV3C site followed by BRIL tag N-terminal truncated SlC2A9 isoform 1 (residue 52-540 as per uniprot). C terminal thrombin site followed by 10X his tag,N-terminal Flag tag, HRV3C site followed by BRIL tag N-terminal truncated SlC2A9 isoform 1 (residue 52-540 as per uniprot). C terminal thrombin site followed by 10X his tag
;
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Cytochrome b-562,Glucose transporter type 9,GLUT-9,Urate transporter' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MASDYKDDDDKGALEVLFQGPSSPMADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDS
PEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLSCSLLVASLAGAFGSSFLYGYNLSVVNAP
TPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQA
GAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVP
AVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVI
VTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTIT
LTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCF
LVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRPGLVPRGSSAHHHHHHHHHHGA
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MASDYKDDDDKGALEVLFQGPSSPMADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDS
PEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLSCSLLVASLAGAFGSSFLYGYNLSVVNAP
TPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQA
GAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVP
AVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVI
VTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTIT
LTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCF
LVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRPGLVPRGSSAHHHHHHHHHHGA
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   SER n 
1 4   ASP n 
1 5   TYR n 
1 6   LYS n 
1 7   ASP n 
1 8   ASP n 
1 9   ASP n 
1 10  ASP n 
1 11  LYS n 
1 12  GLY n 
1 13  ALA n 
1 14  LEU n 
1 15  GLU n 
1 16  VAL n 
1 17  LEU n 
1 18  PHE n 
1 19  GLN n 
1 20  GLY n 
1 21  PRO n 
1 22  SER n 
1 23  SER n 
1 24  PRO n 
1 25  MET n 
1 26  ALA n 
1 27  ASP n 
1 28  LEU n 
1 29  GLU n 
1 30  ASP n 
1 31  ASN n 
1 32  TRP n 
1 33  GLU n 
1 34  THR n 
1 35  LEU n 
1 36  ASN n 
1 37  ASP n 
1 38  ASN n 
1 39  LEU n 
1 40  LYS n 
1 41  VAL n 
1 42  ILE n 
1 43  GLU n 
1 44  LYS n 
1 45  ALA n 
1 46  ASP n 
1 47  ASN n 
1 48  ALA n 
1 49  ALA n 
1 50  GLN n 
1 51  VAL n 
1 52  LYS n 
1 53  ASP n 
1 54  ALA n 
1 55  LEU n 
1 56  THR n 
1 57  LYS n 
1 58  MET n 
1 59  ARG n 
1 60  ALA n 
1 61  ALA n 
1 62  ALA n 
1 63  LEU n 
1 64  ASP n 
1 65  ALA n 
1 66  GLN n 
1 67  LYS n 
1 68  ALA n 
1 69  THR n 
1 70  PRO n 
1 71  PRO n 
1 72  LYS n 
1 73  LEU n 
1 74  GLU n 
1 75  ASP n 
1 76  LYS n 
1 77  SER n 
1 78  PRO n 
1 79  ASP n 
1 80  SER n 
1 81  PRO n 
1 82  GLU n 
1 83  MET n 
1 84  LYS n 
1 85  ASP n 
1 86  PHE n 
1 87  ARG n 
1 88  HIS n 
1 89  GLY n 
1 90  PHE n 
1 91  ASP n 
1 92  ILE n 
1 93  LEU n 
1 94  VAL n 
1 95  GLY n 
1 96  GLN n 
1 97  ILE n 
1 98  ASP n 
1 99  ASP n 
1 100 ALA n 
1 101 LEU n 
1 102 LYS n 
1 103 LEU n 
1 104 ALA n 
1 105 ASN n 
1 106 GLU n 
1 107 GLY n 
1 108 LYS n 
1 109 VAL n 
1 110 LYS n 
1 111 GLU n 
1 112 ALA n 
1 113 GLN n 
1 114 ALA n 
1 115 ALA n 
1 116 ALA n 
1 117 GLU n 
1 118 GLN n 
1 119 LEU n 
1 120 LYS n 
1 121 THR n 
1 122 THR n 
1 123 ARG n 
1 124 ASN n 
1 125 ALA n 
1 126 TYR n 
1 127 ILE n 
1 128 GLN n 
1 129 LYS n 
1 130 TYR n 
1 131 LEU n 
1 132 SER n 
1 133 CYS n 
1 134 SER n 
1 135 LEU n 
1 136 LEU n 
1 137 VAL n 
1 138 ALA n 
1 139 SER n 
1 140 LEU n 
1 141 ALA n 
1 142 GLY n 
1 143 ALA n 
1 144 PHE n 
1 145 GLY n 
1 146 SER n 
1 147 SER n 
1 148 PHE n 
1 149 LEU n 
1 150 TYR n 
1 151 GLY n 
1 152 TYR n 
1 153 ASN n 
1 154 LEU n 
1 155 SER n 
1 156 VAL n 
1 157 VAL n 
1 158 ASN n 
1 159 ALA n 
1 160 PRO n 
1 161 THR n 
1 162 PRO n 
1 163 TYR n 
1 164 ILE n 
1 165 LYS n 
1 166 ALA n 
1 167 PHE n 
1 168 TYR n 
1 169 ASN n 
1 170 GLU n 
1 171 SER n 
1 172 TRP n 
1 173 GLU n 
1 174 ARG n 
1 175 ARG n 
1 176 HIS n 
1 177 GLY n 
1 178 ARG n 
1 179 PRO n 
1 180 ILE n 
1 181 ASP n 
1 182 PRO n 
1 183 ASP n 
1 184 THR n 
1 185 LEU n 
1 186 THR n 
1 187 LEU n 
1 188 LEU n 
1 189 TRP n 
1 190 SER n 
1 191 VAL n 
1 192 THR n 
1 193 VAL n 
1 194 SER n 
1 195 ILE n 
1 196 PHE n 
1 197 ALA n 
1 198 ILE n 
1 199 GLY n 
1 200 GLY n 
1 201 LEU n 
1 202 VAL n 
1 203 GLY n 
1 204 THR n 
1 205 LEU n 
1 206 ILE n 
1 207 VAL n 
1 208 LYS n 
1 209 MET n 
1 210 ILE n 
1 211 GLY n 
1 212 LYS n 
1 213 VAL n 
1 214 LEU n 
1 215 GLY n 
1 216 ARG n 
1 217 LYS n 
1 218 HIS n 
1 219 THR n 
1 220 LEU n 
1 221 LEU n 
1 222 ALA n 
1 223 ASN n 
1 224 ASN n 
1 225 GLY n 
1 226 PHE n 
1 227 ALA n 
1 228 ILE n 
1 229 SER n 
1 230 ALA n 
1 231 ALA n 
1 232 LEU n 
1 233 LEU n 
1 234 MET n 
1 235 ALA n 
1 236 CYS n 
1 237 SER n 
1 238 LEU n 
1 239 GLN n 
1 240 ALA n 
1 241 GLY n 
1 242 ALA n 
1 243 PHE n 
1 244 GLU n 
1 245 MET n 
1 246 LEU n 
1 247 ILE n 
1 248 VAL n 
1 249 GLY n 
1 250 ARG n 
1 251 PHE n 
1 252 ILE n 
1 253 MET n 
1 254 GLY n 
1 255 ILE n 
1 256 ASP n 
1 257 GLY n 
1 258 GLY n 
1 259 VAL n 
1 260 ALA n 
1 261 LEU n 
1 262 SER n 
1 263 VAL n 
1 264 LEU n 
1 265 PRO n 
1 266 MET n 
1 267 TYR n 
1 268 LEU n 
1 269 SER n 
1 270 GLU n 
1 271 ILE n 
1 272 SER n 
1 273 PRO n 
1 274 LYS n 
1 275 GLU n 
1 276 ILE n 
1 277 ARG n 
1 278 GLY n 
1 279 SER n 
1 280 LEU n 
1 281 GLY n 
1 282 GLN n 
1 283 VAL n 
1 284 THR n 
1 285 ALA n 
1 286 ILE n 
1 287 PHE n 
1 288 ILE n 
1 289 CYS n 
1 290 ILE n 
1 291 GLY n 
1 292 VAL n 
1 293 PHE n 
1 294 THR n 
1 295 GLY n 
1 296 GLN n 
1 297 LEU n 
1 298 LEU n 
1 299 GLY n 
1 300 LEU n 
1 301 PRO n 
1 302 GLU n 
1 303 LEU n 
1 304 LEU n 
1 305 GLY n 
1 306 LYS n 
1 307 GLU n 
1 308 SER n 
1 309 THR n 
1 310 TRP n 
1 311 PRO n 
1 312 TYR n 
1 313 LEU n 
1 314 PHE n 
1 315 GLY n 
1 316 VAL n 
1 317 ILE n 
1 318 VAL n 
1 319 VAL n 
1 320 PRO n 
1 321 ALA n 
1 322 VAL n 
1 323 VAL n 
1 324 GLN n 
1 325 LEU n 
1 326 LEU n 
1 327 SER n 
1 328 LEU n 
1 329 PRO n 
1 330 PHE n 
1 331 LEU n 
1 332 PRO n 
1 333 ASP n 
1 334 SER n 
1 335 PRO n 
1 336 ARG n 
1 337 TYR n 
1 338 LEU n 
1 339 LEU n 
1 340 LEU n 
1 341 GLU n 
1 342 LYS n 
1 343 HIS n 
1 344 ASN n 
1 345 GLU n 
1 346 ALA n 
1 347 ARG n 
1 348 ALA n 
1 349 VAL n 
1 350 LYS n 
1 351 ALA n 
1 352 PHE n 
1 353 GLN n 
1 354 THR n 
1 355 PHE n 
1 356 LEU n 
1 357 GLY n 
1 358 LYS n 
1 359 ALA n 
1 360 ASP n 
1 361 VAL n 
1 362 SER n 
1 363 GLN n 
1 364 GLU n 
1 365 VAL n 
1 366 GLU n 
1 367 GLU n 
1 368 VAL n 
1 369 LEU n 
1 370 ALA n 
1 371 GLU n 
1 372 SER n 
1 373 ARG n 
1 374 VAL n 
1 375 GLN n 
1 376 ARG n 
1 377 SER n 
1 378 ILE n 
1 379 ARG n 
1 380 LEU n 
1 381 VAL n 
1 382 SER n 
1 383 VAL n 
1 384 LEU n 
1 385 GLU n 
1 386 LEU n 
1 387 LEU n 
1 388 ARG n 
1 389 ALA n 
1 390 PRO n 
1 391 TYR n 
1 392 VAL n 
1 393 ARG n 
1 394 TRP n 
1 395 GLN n 
1 396 VAL n 
1 397 VAL n 
1 398 THR n 
1 399 VAL n 
1 400 ILE n 
1 401 VAL n 
1 402 THR n 
1 403 MET n 
1 404 ALA n 
1 405 CYS n 
1 406 TYR n 
1 407 GLN n 
1 408 LEU n 
1 409 CYS n 
1 410 GLY n 
1 411 LEU n 
1 412 ASN n 
1 413 ALA n 
1 414 ILE n 
1 415 TRP n 
1 416 PHE n 
1 417 TYR n 
1 418 THR n 
1 419 ASN n 
1 420 SER n 
1 421 ILE n 
1 422 PHE n 
1 423 GLY n 
1 424 LYS n 
1 425 ALA n 
1 426 GLY n 
1 427 ILE n 
1 428 PRO n 
1 429 PRO n 
1 430 ALA n 
1 431 LYS n 
1 432 ILE n 
1 433 PRO n 
1 434 TYR n 
1 435 VAL n 
1 436 THR n 
1 437 LEU n 
1 438 SER n 
1 439 THR n 
1 440 GLY n 
1 441 GLY n 
1 442 ILE n 
1 443 GLU n 
1 444 THR n 
1 445 LEU n 
1 446 ALA n 
1 447 ALA n 
1 448 VAL n 
1 449 PHE n 
1 450 SER n 
1 451 GLY n 
1 452 LEU n 
1 453 VAL n 
1 454 ILE n 
1 455 GLU n 
1 456 HIS n 
1 457 LEU n 
1 458 GLY n 
1 459 ARG n 
1 460 ARG n 
1 461 PRO n 
1 462 LEU n 
1 463 LEU n 
1 464 ILE n 
1 465 GLY n 
1 466 GLY n 
1 467 PHE n 
1 468 GLY n 
1 469 LEU n 
1 470 MET n 
1 471 GLY n 
1 472 LEU n 
1 473 PHE n 
1 474 PHE n 
1 475 GLY n 
1 476 THR n 
1 477 LEU n 
1 478 THR n 
1 479 ILE n 
1 480 THR n 
1 481 LEU n 
1 482 THR n 
1 483 LEU n 
1 484 GLN n 
1 485 ASP n 
1 486 HIS n 
1 487 ALA n 
1 488 PRO n 
1 489 TRP n 
1 490 VAL n 
1 491 PRO n 
1 492 TYR n 
1 493 LEU n 
1 494 SER n 
1 495 ILE n 
1 496 VAL n 
1 497 GLY n 
1 498 ILE n 
1 499 LEU n 
1 500 ALA n 
1 501 ILE n 
1 502 ILE n 
1 503 ALA n 
1 504 SER n 
1 505 PHE n 
1 506 CYS n 
1 507 SER n 
1 508 GLY n 
1 509 PRO n 
1 510 GLY n 
1 511 GLY n 
1 512 ILE n 
1 513 PRO n 
1 514 PHE n 
1 515 ILE n 
1 516 LEU n 
1 517 THR n 
1 518 GLY n 
1 519 GLU n 
1 520 PHE n 
1 521 PHE n 
1 522 GLN n 
1 523 GLN n 
1 524 SER n 
1 525 GLN n 
1 526 ARG n 
1 527 PRO n 
1 528 ALA n 
1 529 ALA n 
1 530 PHE n 
1 531 ILE n 
1 532 ILE n 
1 533 ALA n 
1 534 GLY n 
1 535 THR n 
1 536 VAL n 
1 537 ASN n 
1 538 TRP n 
1 539 LEU n 
1 540 SER n 
1 541 ASN n 
1 542 PHE n 
1 543 ALA n 
1 544 VAL n 
1 545 GLY n 
1 546 LEU n 
1 547 LEU n 
1 548 PHE n 
1 549 PRO n 
1 550 PHE n 
1 551 ILE n 
1 552 GLN n 
1 553 LYS n 
1 554 SER n 
1 555 LEU n 
1 556 ASP n 
1 557 THR n 
1 558 TYR n 
1 559 CYS n 
1 560 PHE n 
1 561 LEU n 
1 562 VAL n 
1 563 PHE n 
1 564 ALA n 
1 565 THR n 
1 566 ILE n 
1 567 CYS n 
1 568 ILE n 
1 569 THR n 
1 570 GLY n 
1 571 ALA n 
1 572 ILE n 
1 573 TYR n 
1 574 LEU n 
1 575 TYR n 
1 576 PHE n 
1 577 VAL n 
1 578 LEU n 
1 579 PRO n 
1 580 GLU n 
1 581 THR n 
1 582 LYS n 
1 583 ASN n 
1 584 ARG n 
1 585 THR n 
1 586 TYR n 
1 587 ALA n 
1 588 GLU n 
1 589 ILE n 
1 590 SER n 
1 591 GLN n 
1 592 ALA n 
1 593 PHE n 
1 594 SER n 
1 595 LYS n 
1 596 ARG n 
1 597 ASN n 
1 598 LYS n 
1 599 ALA n 
1 600 TYR n 
1 601 PRO n 
1 602 PRO n 
1 603 GLU n 
1 604 GLU n 
1 605 LYS n 
1 606 ILE n 
1 607 ASP n 
1 608 SER n 
1 609 ALA n 
1 610 VAL n 
1 611 THR n 
1 612 ASP n 
1 613 GLY n 
1 614 LYS n 
1 615 ILE n 
1 616 ASN n 
1 617 GLY n 
1 618 ARG n 
1 619 PRO n 
1 620 GLY n 
1 621 LEU n 
1 622 VAL n 
1 623 PRO n 
1 624 ARG n 
1 625 GLY n 
1 626 SER n 
1 627 SER n 
1 628 ALA n 
1 629 HIS n 
1 630 HIS n 
1 631 HIS n 
1 632 HIS n 
1 633 HIS n 
1 634 HIS n 
1 635 HIS n 
1 636 HIS n 
1 637 HIS n 
1 638 HIS n 
1 639 GLY n 
1 640 ALA n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   131 human ? cybC            ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Saccharomyces cerevisiae' 4932 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? '83 nu vector' ? ? 
1 2 sample 'Biological sequence' 132 640 human ? 'SLC2A9, GLUT9' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 
'Saccharomyces cerevisiae' 4932 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? '83 nu vector' ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -78 ?   ?   ?   A . n 
A 1 2   ALA 2   -77 ?   ?   ?   A . n 
A 1 3   SER 3   -76 ?   ?   ?   A . n 
A 1 4   ASP 4   -75 ?   ?   ?   A . n 
A 1 5   TYR 5   -74 ?   ?   ?   A . n 
A 1 6   LYS 6   -73 ?   ?   ?   A . n 
A 1 7   ASP 7   -72 ?   ?   ?   A . n 
A 1 8   ASP 8   -71 ?   ?   ?   A . n 
A 1 9   ASP 9   -70 ?   ?   ?   A . n 
A 1 10  ASP 10  -69 ?   ?   ?   A . n 
A 1 11  LYS 11  -68 ?   ?   ?   A . n 
A 1 12  GLY 12  -67 ?   ?   ?   A . n 
A 1 13  ALA 13  -66 ?   ?   ?   A . n 
A 1 14  LEU 14  -65 ?   ?   ?   A . n 
A 1 15  GLU 15  -64 ?   ?   ?   A . n 
A 1 16  VAL 16  -63 ?   ?   ?   A . n 
A 1 17  LEU 17  -62 ?   ?   ?   A . n 
A 1 18  PHE 18  -61 ?   ?   ?   A . n 
A 1 19  GLN 19  -60 ?   ?   ?   A . n 
A 1 20  GLY 20  -59 ?   ?   ?   A . n 
A 1 21  PRO 21  -58 ?   ?   ?   A . n 
A 1 22  SER 22  -57 ?   ?   ?   A . n 
A 1 23  SER 23  -56 ?   ?   ?   A . n 
A 1 24  PRO 24  -55 ?   ?   ?   A . n 
A 1 25  MET 25  -54 ?   ?   ?   A . n 
A 1 26  ALA 26  -53 ?   ?   ?   A . n 
A 1 27  ASP 27  -52 ?   ?   ?   A . n 
A 1 28  LEU 28  -51 ?   ?   ?   A . n 
A 1 29  GLU 29  -50 ?   ?   ?   A . n 
A 1 30  ASP 30  -49 ?   ?   ?   A . n 
A 1 31  ASN 31  -48 ?   ?   ?   A . n 
A 1 32  TRP 32  -47 ?   ?   ?   A . n 
A 1 33  GLU 33  -46 ?   ?   ?   A . n 
A 1 34  THR 34  -45 ?   ?   ?   A . n 
A 1 35  LEU 35  -44 ?   ?   ?   A . n 
A 1 36  ASN 36  -43 ?   ?   ?   A . n 
A 1 37  ASP 37  -42 ?   ?   ?   A . n 
A 1 38  ASN 38  -41 ?   ?   ?   A . n 
A 1 39  LEU 39  -40 ?   ?   ?   A . n 
A 1 40  LYS 40  -39 ?   ?   ?   A . n 
A 1 41  VAL 41  -38 ?   ?   ?   A . n 
A 1 42  ILE 42  -37 ?   ?   ?   A . n 
A 1 43  GLU 43  -36 ?   ?   ?   A . n 
A 1 44  LYS 44  -35 ?   ?   ?   A . n 
A 1 45  ALA 45  -34 ?   ?   ?   A . n 
A 1 46  ASP 46  -33 ?   ?   ?   A . n 
A 1 47  ASN 47  -32 ?   ?   ?   A . n 
A 1 48  ALA 48  -31 ?   ?   ?   A . n 
A 1 49  ALA 49  -30 ?   ?   ?   A . n 
A 1 50  GLN 50  -29 ?   ?   ?   A . n 
A 1 51  VAL 51  -28 ?   ?   ?   A . n 
A 1 52  LYS 52  -27 ?   ?   ?   A . n 
A 1 53  ASP 53  -26 ?   ?   ?   A . n 
A 1 54  ALA 54  -25 ?   ?   ?   A . n 
A 1 55  LEU 55  -24 ?   ?   ?   A . n 
A 1 56  THR 56  -23 ?   ?   ?   A . n 
A 1 57  LYS 57  -22 ?   ?   ?   A . n 
A 1 58  MET 58  -21 ?   ?   ?   A . n 
A 1 59  ARG 59  -20 ?   ?   ?   A . n 
A 1 60  ALA 60  -19 ?   ?   ?   A . n 
A 1 61  ALA 61  -18 ?   ?   ?   A . n 
A 1 62  ALA 62  -17 ?   ?   ?   A . n 
A 1 63  LEU 63  -16 ?   ?   ?   A . n 
A 1 64  ASP 64  -15 ?   ?   ?   A . n 
A 1 65  ALA 65  -14 ?   ?   ?   A . n 
A 1 66  GLN 66  -13 ?   ?   ?   A . n 
A 1 67  LYS 67  -12 ?   ?   ?   A . n 
A 1 68  ALA 68  -11 ?   ?   ?   A . n 
A 1 69  THR 69  -10 ?   ?   ?   A . n 
A 1 70  PRO 70  -9  ?   ?   ?   A . n 
A 1 71  PRO 71  -8  ?   ?   ?   A . n 
A 1 72  LYS 72  -7  ?   ?   ?   A . n 
A 1 73  LEU 73  -6  ?   ?   ?   A . n 
A 1 74  GLU 74  -5  ?   ?   ?   A . n 
A 1 75  ASP 75  -4  ?   ?   ?   A . n 
A 1 76  LYS 76  -3  ?   ?   ?   A . n 
A 1 77  SER 77  -2  ?   ?   ?   A . n 
A 1 78  PRO 78  -1  ?   ?   ?   A . n 
A 1 79  ASP 79  0   ?   ?   ?   A . n 
A 1 80  SER 80  1   ?   ?   ?   A . n 
A 1 81  PRO 81  2   ?   ?   ?   A . n 
A 1 82  GLU 82  3   ?   ?   ?   A . n 
A 1 83  MET 83  4   ?   ?   ?   A . n 
A 1 84  LYS 84  5   ?   ?   ?   A . n 
A 1 85  ASP 85  6   ?   ?   ?   A . n 
A 1 86  PHE 86  7   ?   ?   ?   A . n 
A 1 87  ARG 87  8   ?   ?   ?   A . n 
A 1 88  HIS 88  9   ?   ?   ?   A . n 
A 1 89  GLY 89  10  ?   ?   ?   A . n 
A 1 90  PHE 90  11  ?   ?   ?   A . n 
A 1 91  ASP 91  12  ?   ?   ?   A . n 
A 1 92  ILE 92  13  ?   ?   ?   A . n 
A 1 93  LEU 93  14  ?   ?   ?   A . n 
A 1 94  VAL 94  15  ?   ?   ?   A . n 
A 1 95  GLY 95  16  ?   ?   ?   A . n 
A 1 96  GLN 96  17  ?   ?   ?   A . n 
A 1 97  ILE 97  18  ?   ?   ?   A . n 
A 1 98  ASP 98  19  ?   ?   ?   A . n 
A 1 99  ASP 99  20  ?   ?   ?   A . n 
A 1 100 ALA 100 21  ?   ?   ?   A . n 
A 1 101 LEU 101 22  ?   ?   ?   A . n 
A 1 102 LYS 102 23  ?   ?   ?   A . n 
A 1 103 LEU 103 24  ?   ?   ?   A . n 
A 1 104 ALA 104 25  ?   ?   ?   A . n 
A 1 105 ASN 105 26  ?   ?   ?   A . n 
A 1 106 GLU 106 27  ?   ?   ?   A . n 
A 1 107 GLY 107 28  ?   ?   ?   A . n 
A 1 108 LYS 108 29  ?   ?   ?   A . n 
A 1 109 VAL 109 30  ?   ?   ?   A . n 
A 1 110 LYS 110 31  ?   ?   ?   A . n 
A 1 111 GLU 111 32  ?   ?   ?   A . n 
A 1 112 ALA 112 33  ?   ?   ?   A . n 
A 1 113 GLN 113 34  ?   ?   ?   A . n 
A 1 114 ALA 114 35  ?   ?   ?   A . n 
A 1 115 ALA 115 36  ?   ?   ?   A . n 
A 1 116 ALA 116 37  ?   ?   ?   A . n 
A 1 117 GLU 117 38  ?   ?   ?   A . n 
A 1 118 GLN 118 39  ?   ?   ?   A . n 
A 1 119 LEU 119 40  ?   ?   ?   A . n 
A 1 120 LYS 120 41  ?   ?   ?   A . n 
A 1 121 THR 121 42  ?   ?   ?   A . n 
A 1 122 THR 122 43  ?   ?   ?   A . n 
A 1 123 ARG 123 44  ?   ?   ?   A . n 
A 1 124 ASN 124 45  ?   ?   ?   A . n 
A 1 125 ALA 125 46  ?   ?   ?   A . n 
A 1 126 TYR 126 47  ?   ?   ?   A . n 
A 1 127 ILE 127 48  ?   ?   ?   A . n 
A 1 128 GLN 128 49  ?   ?   ?   A . n 
A 1 129 LYS 129 50  ?   ?   ?   A . n 
A 1 130 TYR 130 51  ?   ?   ?   A . n 
A 1 131 LEU 131 52  ?   ?   ?   A . n 
A 1 132 SER 132 53  53  SER SER A . n 
A 1 133 CYS 133 54  54  CYS CYS A . n 
A 1 134 SER 134 55  55  SER SER A . n 
A 1 135 LEU 135 56  56  LEU LEU A . n 
A 1 136 LEU 136 57  57  LEU LEU A . n 
A 1 137 VAL 137 58  58  VAL VAL A . n 
A 1 138 ALA 138 59  59  ALA ALA A . n 
A 1 139 SER 139 60  60  SER SER A . n 
A 1 140 LEU 140 61  61  LEU LEU A . n 
A 1 141 ALA 141 62  62  ALA ALA A . n 
A 1 142 GLY 142 63  63  GLY GLY A . n 
A 1 143 ALA 143 64  64  ALA ALA A . n 
A 1 144 PHE 144 65  65  PHE PHE A . n 
A 1 145 GLY 145 66  66  GLY GLY A . n 
A 1 146 SER 146 67  67  SER SER A . n 
A 1 147 SER 147 68  68  SER SER A . n 
A 1 148 PHE 148 69  69  PHE PHE A . n 
A 1 149 LEU 149 70  70  LEU LEU A . n 
A 1 150 TYR 150 71  71  TYR TYR A . n 
A 1 151 GLY 151 72  72  GLY GLY A . n 
A 1 152 TYR 152 73  73  TYR TYR A . n 
A 1 153 ASN 153 74  74  ASN ASN A . n 
A 1 154 LEU 154 75  75  LEU LEU A . n 
A 1 155 SER 155 76  76  SER SER A . n 
A 1 156 VAL 156 77  77  VAL VAL A . n 
A 1 157 VAL 157 78  78  VAL VAL A . n 
A 1 158 ASN 158 79  79  ASN ASN A . n 
A 1 159 ALA 159 80  80  ALA ALA A . n 
A 1 160 PRO 160 81  81  PRO PRO A . n 
A 1 161 THR 161 82  82  THR THR A . n 
A 1 162 PRO 162 83  83  PRO PRO A . n 
A 1 163 TYR 163 84  84  TYR TYR A . n 
A 1 164 ILE 164 85  85  ILE ILE A . n 
A 1 165 LYS 165 86  86  LYS LYS A . n 
A 1 166 ALA 166 87  87  ALA ALA A . n 
A 1 167 PHE 167 88  88  PHE PHE A . n 
A 1 168 TYR 168 89  89  TYR TYR A . n 
A 1 169 ASN 169 90  90  ASN ASN A . n 
A 1 170 GLU 170 91  91  GLU GLU A . n 
A 1 171 SER 171 92  92  SER SER A . n 
A 1 172 TRP 172 93  93  TRP TRP A . n 
A 1 173 GLU 173 94  94  GLU GLU A . n 
A 1 174 ARG 174 95  95  ARG ARG A . n 
A 1 175 ARG 175 96  96  ARG ARG A . n 
A 1 176 HIS 176 97  97  HIS HIS A . n 
A 1 177 GLY 177 98  98  GLY GLY A . n 
A 1 178 ARG 178 99  99  ARG ARG A . n 
A 1 179 PRO 179 100 100 PRO PRO A . n 
A 1 180 ILE 180 101 101 ILE ILE A . n 
A 1 181 ASP 181 102 102 ASP ASP A . n 
A 1 182 PRO 182 103 103 PRO PRO A . n 
A 1 183 ASP 183 104 104 ASP ASP A . n 
A 1 184 THR 184 105 105 THR THR A . n 
A 1 185 LEU 185 106 106 LEU LEU A . n 
A 1 186 THR 186 107 107 THR THR A . n 
A 1 187 LEU 187 108 108 LEU LEU A . n 
A 1 188 LEU 188 109 109 LEU LEU A . n 
A 1 189 TRP 189 110 110 TRP TRP A . n 
A 1 190 SER 190 111 111 SER SER A . n 
A 1 191 VAL 191 112 112 VAL VAL A . n 
A 1 192 THR 192 113 113 THR THR A . n 
A 1 193 VAL 193 114 114 VAL VAL A . n 
A 1 194 SER 194 115 115 SER SER A . n 
A 1 195 ILE 195 116 116 ILE ILE A . n 
A 1 196 PHE 196 117 117 PHE PHE A . n 
A 1 197 ALA 197 118 118 ALA ALA A . n 
A 1 198 ILE 198 119 119 ILE ILE A . n 
A 1 199 GLY 199 120 120 GLY GLY A . n 
A 1 200 GLY 200 121 121 GLY GLY A . n 
A 1 201 LEU 201 122 122 LEU LEU A . n 
A 1 202 VAL 202 123 123 VAL VAL A . n 
A 1 203 GLY 203 124 124 GLY GLY A . n 
A 1 204 THR 204 125 125 THR THR A . n 
A 1 205 LEU 205 126 126 LEU LEU A . n 
A 1 206 ILE 206 127 127 ILE ILE A . n 
A 1 207 VAL 207 128 128 VAL VAL A . n 
A 1 208 LYS 208 129 129 LYS LYS A . n 
A 1 209 MET 209 130 130 MET MET A . n 
A 1 210 ILE 210 131 131 ILE ILE A . n 
A 1 211 GLY 211 132 132 GLY GLY A . n 
A 1 212 LYS 212 133 133 LYS LYS A . n 
A 1 213 VAL 213 134 134 VAL VAL A . n 
A 1 214 LEU 214 135 135 LEU LEU A . n 
A 1 215 GLY 215 136 136 GLY GLY A . n 
A 1 216 ARG 216 137 137 ARG ARG A . n 
A 1 217 LYS 217 138 138 LYS LYS A . n 
A 1 218 HIS 218 139 139 HIS HIS A . n 
A 1 219 THR 219 140 140 THR THR A . n 
A 1 220 LEU 220 141 141 LEU LEU A . n 
A 1 221 LEU 221 142 142 LEU LEU A . n 
A 1 222 ALA 222 143 143 ALA ALA A . n 
A 1 223 ASN 223 144 144 ASN ASN A . n 
A 1 224 ASN 224 145 145 ASN ASN A . n 
A 1 225 GLY 225 146 146 GLY GLY A . n 
A 1 226 PHE 226 147 147 PHE PHE A . n 
A 1 227 ALA 227 148 148 ALA ALA A . n 
A 1 228 ILE 228 149 149 ILE ILE A . n 
A 1 229 SER 229 150 150 SER SER A . n 
A 1 230 ALA 230 151 151 ALA ALA A . n 
A 1 231 ALA 231 152 152 ALA ALA A . n 
A 1 232 LEU 232 153 153 LEU LEU A . n 
A 1 233 LEU 233 154 154 LEU LEU A . n 
A 1 234 MET 234 155 155 MET MET A . n 
A 1 235 ALA 235 156 156 ALA ALA A . n 
A 1 236 CYS 236 157 157 CYS CYS A . n 
A 1 237 SER 237 158 158 SER SER A . n 
A 1 238 LEU 238 159 159 LEU LEU A . n 
A 1 239 GLN 239 160 160 GLN GLN A . n 
A 1 240 ALA 240 161 161 ALA ALA A . n 
A 1 241 GLY 241 162 162 GLY GLY A . n 
A 1 242 ALA 242 163 163 ALA ALA A . n 
A 1 243 PHE 243 164 164 PHE PHE A . n 
A 1 244 GLU 244 165 165 GLU GLU A . n 
A 1 245 MET 245 166 166 MET MET A . n 
A 1 246 LEU 246 167 167 LEU LEU A . n 
A 1 247 ILE 247 168 168 ILE ILE A . n 
A 1 248 VAL 248 169 169 VAL VAL A . n 
A 1 249 GLY 249 170 170 GLY GLY A . n 
A 1 250 ARG 250 171 171 ARG ARG A . n 
A 1 251 PHE 251 172 172 PHE PHE A . n 
A 1 252 ILE 252 173 173 ILE ILE A . n 
A 1 253 MET 253 174 174 MET MET A . n 
A 1 254 GLY 254 175 175 GLY GLY A . n 
A 1 255 ILE 255 176 176 ILE ILE A . n 
A 1 256 ASP 256 177 177 ASP ASP A . n 
A 1 257 GLY 257 178 178 GLY GLY A . n 
A 1 258 GLY 258 179 179 GLY GLY A . n 
A 1 259 VAL 259 180 180 VAL VAL A . n 
A 1 260 ALA 260 181 181 ALA ALA A . n 
A 1 261 LEU 261 182 182 LEU LEU A . n 
A 1 262 SER 262 183 183 SER SER A . n 
A 1 263 VAL 263 184 184 VAL VAL A . n 
A 1 264 LEU 264 185 185 LEU LEU A . n 
A 1 265 PRO 265 186 186 PRO PRO A . n 
A 1 266 MET 266 187 187 MET MET A . n 
A 1 267 TYR 267 188 188 TYR TYR A . n 
A 1 268 LEU 268 189 189 LEU LEU A . n 
A 1 269 SER 269 190 190 SER SER A . n 
A 1 270 GLU 270 191 191 GLU GLU A . n 
A 1 271 ILE 271 192 192 ILE ILE A . n 
A 1 272 SER 272 193 193 SER SER A . n 
A 1 273 PRO 273 194 194 PRO PRO A . n 
A 1 274 LYS 274 195 195 LYS LYS A . n 
A 1 275 GLU 275 196 196 GLU GLU A . n 
A 1 276 ILE 276 197 197 ILE ILE A . n 
A 1 277 ARG 277 198 198 ARG ARG A . n 
A 1 278 GLY 278 199 199 GLY GLY A . n 
A 1 279 SER 279 200 200 SER SER A . n 
A 1 280 LEU 280 201 201 LEU LEU A . n 
A 1 281 GLY 281 202 202 GLY GLY A . n 
A 1 282 GLN 282 203 203 GLN GLN A . n 
A 1 283 VAL 283 204 204 VAL VAL A . n 
A 1 284 THR 284 205 205 THR THR A . n 
A 1 285 ALA 285 206 206 ALA ALA A . n 
A 1 286 ILE 286 207 207 ILE ILE A . n 
A 1 287 PHE 287 208 208 PHE PHE A . n 
A 1 288 ILE 288 209 209 ILE ILE A . n 
A 1 289 CYS 289 210 210 CYS CYS A . n 
A 1 290 ILE 290 211 211 ILE ILE A . n 
A 1 291 GLY 291 212 212 GLY GLY A . n 
A 1 292 VAL 292 213 213 VAL VAL A . n 
A 1 293 PHE 293 214 214 PHE PHE A . n 
A 1 294 THR 294 215 215 THR THR A . n 
A 1 295 GLY 295 216 216 GLY GLY A . n 
A 1 296 GLN 296 217 217 GLN GLN A . n 
A 1 297 LEU 297 218 218 LEU LEU A . n 
A 1 298 LEU 298 219 219 LEU LEU A . n 
A 1 299 GLY 299 220 220 GLY GLY A . n 
A 1 300 LEU 300 221 221 LEU LEU A . n 
A 1 301 PRO 301 222 222 PRO PRO A . n 
A 1 302 GLU 302 223 223 GLU GLU A . n 
A 1 303 LEU 303 224 224 LEU LEU A . n 
A 1 304 LEU 304 225 225 LEU LEU A . n 
A 1 305 GLY 305 226 226 GLY GLY A . n 
A 1 306 LYS 306 227 227 LYS LYS A . n 
A 1 307 GLU 307 228 228 GLU GLU A . n 
A 1 308 SER 308 229 229 SER SER A . n 
A 1 309 THR 309 230 230 THR THR A . n 
A 1 310 TRP 310 231 231 TRP TRP A . n 
A 1 311 PRO 311 232 232 PRO PRO A . n 
A 1 312 TYR 312 233 233 TYR TYR A . n 
A 1 313 LEU 313 234 234 LEU LEU A . n 
A 1 314 PHE 314 235 235 PHE PHE A . n 
A 1 315 GLY 315 236 236 GLY GLY A . n 
A 1 316 VAL 316 237 237 VAL VAL A . n 
A 1 317 ILE 317 238 238 ILE ILE A . n 
A 1 318 VAL 318 239 239 VAL VAL A . n 
A 1 319 VAL 319 240 240 VAL VAL A . n 
A 1 320 PRO 320 241 241 PRO PRO A . n 
A 1 321 ALA 321 242 242 ALA ALA A . n 
A 1 322 VAL 322 243 243 VAL VAL A . n 
A 1 323 VAL 323 244 244 VAL VAL A . n 
A 1 324 GLN 324 245 245 GLN GLN A . n 
A 1 325 LEU 325 246 246 LEU LEU A . n 
A 1 326 LEU 326 247 247 LEU LEU A . n 
A 1 327 SER 327 248 248 SER SER A . n 
A 1 328 LEU 328 249 249 LEU LEU A . n 
A 1 329 PRO 329 250 250 PRO PRO A . n 
A 1 330 PHE 330 251 251 PHE PHE A . n 
A 1 331 LEU 331 252 252 LEU LEU A . n 
A 1 332 PRO 332 253 253 PRO PRO A . n 
A 1 333 ASP 333 254 254 ASP ASP A . n 
A 1 334 SER 334 255 255 SER SER A . n 
A 1 335 PRO 335 256 256 PRO PRO A . n 
A 1 336 ARG 336 257 257 ARG ARG A . n 
A 1 337 TYR 337 258 258 TYR TYR A . n 
A 1 338 LEU 338 259 259 LEU LEU A . n 
A 1 339 LEU 339 260 260 LEU LEU A . n 
A 1 340 LEU 340 261 261 LEU LEU A . n 
A 1 341 GLU 341 262 262 GLU GLU A . n 
A 1 342 LYS 342 263 263 LYS LYS A . n 
A 1 343 HIS 343 264 264 HIS HIS A . n 
A 1 344 ASN 344 265 265 ASN ASN A . n 
A 1 345 GLU 345 266 266 GLU GLU A . n 
A 1 346 ALA 346 267 267 ALA ALA A . n 
A 1 347 ARG 347 268 268 ARG ARG A . n 
A 1 348 ALA 348 269 269 ALA ALA A . n 
A 1 349 VAL 349 270 270 VAL VAL A . n 
A 1 350 LYS 350 271 271 LYS LYS A . n 
A 1 351 ALA 351 272 272 ALA ALA A . n 
A 1 352 PHE 352 273 273 PHE PHE A . n 
A 1 353 GLN 353 274 274 GLN GLN A . n 
A 1 354 THR 354 275 275 THR THR A . n 
A 1 355 PHE 355 276 276 PHE PHE A . n 
A 1 356 LEU 356 277 277 LEU LEU A . n 
A 1 357 GLY 357 278 278 GLY GLY A . n 
A 1 358 LYS 358 279 279 LYS LYS A . n 
A 1 359 ALA 359 280 280 ALA ALA A . n 
A 1 360 ASP 360 281 281 ASP ASP A . n 
A 1 361 VAL 361 282 282 VAL VAL A . n 
A 1 362 SER 362 283 283 SER SER A . n 
A 1 363 GLN 363 284 284 GLN GLN A . n 
A 1 364 GLU 364 285 285 GLU GLU A . n 
A 1 365 VAL 365 286 286 VAL VAL A . n 
A 1 366 GLU 366 287 287 GLU GLU A . n 
A 1 367 GLU 367 288 288 GLU GLU A . n 
A 1 368 VAL 368 289 289 VAL VAL A . n 
A 1 369 LEU 369 290 290 LEU LEU A . n 
A 1 370 ALA 370 291 291 ALA ALA A . n 
A 1 371 GLU 371 292 292 GLU GLU A . n 
A 1 372 SER 372 293 293 SER SER A . n 
A 1 373 ARG 373 294 294 ARG ARG A . n 
A 1 374 VAL 374 295 295 VAL VAL A . n 
A 1 375 GLN 375 296 296 GLN GLN A . n 
A 1 376 ARG 376 297 297 ARG ARG A . n 
A 1 377 SER 377 298 298 SER SER A . n 
A 1 378 ILE 378 299 299 ILE ILE A . n 
A 1 379 ARG 379 300 300 ARG ARG A . n 
A 1 380 LEU 380 301 301 LEU LEU A . n 
A 1 381 VAL 381 302 302 VAL VAL A . n 
A 1 382 SER 382 303 303 SER SER A . n 
A 1 383 VAL 383 304 304 VAL VAL A . n 
A 1 384 LEU 384 305 305 LEU LEU A . n 
A 1 385 GLU 385 306 306 GLU GLU A . n 
A 1 386 LEU 386 307 307 LEU LEU A . n 
A 1 387 LEU 387 308 308 LEU LEU A . n 
A 1 388 ARG 388 309 309 ARG ARG A . n 
A 1 389 ALA 389 310 310 ALA ALA A . n 
A 1 390 PRO 390 311 311 PRO PRO A . n 
A 1 391 TYR 391 312 312 TYR TYR A . n 
A 1 392 VAL 392 313 313 VAL VAL A . n 
A 1 393 ARG 393 314 314 ARG ARG A . n 
A 1 394 TRP 394 315 315 TRP TRP A . n 
A 1 395 GLN 395 316 316 GLN GLN A . n 
A 1 396 VAL 396 317 317 VAL VAL A . n 
A 1 397 VAL 397 318 318 VAL VAL A . n 
A 1 398 THR 398 319 319 THR THR A . n 
A 1 399 VAL 399 320 320 VAL VAL A . n 
A 1 400 ILE 400 321 321 ILE ILE A . n 
A 1 401 VAL 401 322 322 VAL VAL A . n 
A 1 402 THR 402 323 323 THR THR A . n 
A 1 403 MET 403 324 324 MET MET A . n 
A 1 404 ALA 404 325 325 ALA ALA A . n 
A 1 405 CYS 405 326 326 CYS CYS A . n 
A 1 406 TYR 406 327 327 TYR TYR A . n 
A 1 407 GLN 407 328 328 GLN GLN A . n 
A 1 408 LEU 408 329 329 LEU LEU A . n 
A 1 409 CYS 409 330 330 CYS CYS A . n 
A 1 410 GLY 410 331 331 GLY GLY A . n 
A 1 411 LEU 411 332 332 LEU LEU A . n 
A 1 412 ASN 412 333 333 ASN ASN A . n 
A 1 413 ALA 413 334 334 ALA ALA A . n 
A 1 414 ILE 414 335 335 ILE ILE A . n 
A 1 415 TRP 415 336 336 TRP TRP A . n 
A 1 416 PHE 416 337 337 PHE PHE A . n 
A 1 417 TYR 417 338 338 TYR TYR A . n 
A 1 418 THR 418 339 339 THR THR A . n 
A 1 419 ASN 419 340 340 ASN ASN A . n 
A 1 420 SER 420 341 341 SER SER A . n 
A 1 421 ILE 421 342 342 ILE ILE A . n 
A 1 422 PHE 422 343 343 PHE PHE A . n 
A 1 423 GLY 423 344 344 GLY GLY A . n 
A 1 424 LYS 424 345 345 LYS LYS A . n 
A 1 425 ALA 425 346 346 ALA ALA A . n 
A 1 426 GLY 426 347 347 GLY GLY A . n 
A 1 427 ILE 427 348 348 ILE ILE A . n 
A 1 428 PRO 428 349 349 PRO PRO A . n 
A 1 429 PRO 429 350 350 PRO PRO A . n 
A 1 430 ALA 430 351 351 ALA ALA A . n 
A 1 431 LYS 431 352 352 LYS LYS A . n 
A 1 432 ILE 432 353 353 ILE ILE A . n 
A 1 433 PRO 433 354 354 PRO PRO A . n 
A 1 434 TYR 434 355 355 TYR TYR A . n 
A 1 435 VAL 435 356 356 VAL VAL A . n 
A 1 436 THR 436 357 357 THR THR A . n 
A 1 437 LEU 437 358 358 LEU LEU A . n 
A 1 438 SER 438 359 359 SER SER A . n 
A 1 439 THR 439 360 360 THR THR A . n 
A 1 440 GLY 440 361 361 GLY GLY A . n 
A 1 441 GLY 441 362 362 GLY GLY A . n 
A 1 442 ILE 442 363 363 ILE ILE A . n 
A 1 443 GLU 443 364 364 GLU GLU A . n 
A 1 444 THR 444 365 365 THR THR A . n 
A 1 445 LEU 445 366 366 LEU LEU A . n 
A 1 446 ALA 446 367 367 ALA ALA A . n 
A 1 447 ALA 447 368 368 ALA ALA A . n 
A 1 448 VAL 448 369 369 VAL VAL A . n 
A 1 449 PHE 449 370 370 PHE PHE A . n 
A 1 450 SER 450 371 371 SER SER A . n 
A 1 451 GLY 451 372 372 GLY GLY A . n 
A 1 452 LEU 452 373 373 LEU LEU A . n 
A 1 453 VAL 453 374 374 VAL VAL A . n 
A 1 454 ILE 454 375 375 ILE ILE A . n 
A 1 455 GLU 455 376 376 GLU GLU A . n 
A 1 456 HIS 456 377 377 HIS HIS A . n 
A 1 457 LEU 457 378 378 LEU LEU A . n 
A 1 458 GLY 458 379 379 GLY GLY A . n 
A 1 459 ARG 459 380 380 ARG ARG A . n 
A 1 460 ARG 460 381 381 ARG ARG A . n 
A 1 461 PRO 461 382 382 PRO PRO A . n 
A 1 462 LEU 462 383 383 LEU LEU A . n 
A 1 463 LEU 463 384 384 LEU LEU A . n 
A 1 464 ILE 464 385 385 ILE ILE A . n 
A 1 465 GLY 465 386 386 GLY GLY A . n 
A 1 466 GLY 466 387 387 GLY GLY A . n 
A 1 467 PHE 467 388 388 PHE PHE A . n 
A 1 468 GLY 468 389 389 GLY GLY A . n 
A 1 469 LEU 469 390 390 LEU LEU A . n 
A 1 470 MET 470 391 391 MET MET A . n 
A 1 471 GLY 471 392 392 GLY GLY A . n 
A 1 472 LEU 472 393 393 LEU LEU A . n 
A 1 473 PHE 473 394 394 PHE PHE A . n 
A 1 474 PHE 474 395 395 PHE PHE A . n 
A 1 475 GLY 475 396 396 GLY GLY A . n 
A 1 476 THR 476 397 397 THR THR A . n 
A 1 477 LEU 477 398 398 LEU LEU A . n 
A 1 478 THR 478 399 399 THR THR A . n 
A 1 479 ILE 479 400 400 ILE ILE A . n 
A 1 480 THR 480 401 401 THR THR A . n 
A 1 481 LEU 481 402 402 LEU LEU A . n 
A 1 482 THR 482 403 403 THR THR A . n 
A 1 483 LEU 483 404 404 LEU LEU A . n 
A 1 484 GLN 484 405 405 GLN GLN A . n 
A 1 485 ASP 485 406 406 ASP ASP A . n 
A 1 486 HIS 486 407 407 HIS HIS A . n 
A 1 487 ALA 487 408 408 ALA ALA A . n 
A 1 488 PRO 488 409 409 PRO PRO A . n 
A 1 489 TRP 489 410 410 TRP TRP A . n 
A 1 490 VAL 490 411 411 VAL VAL A . n 
A 1 491 PRO 491 412 412 PRO PRO A . n 
A 1 492 TYR 492 413 413 TYR TYR A . n 
A 1 493 LEU 493 414 414 LEU LEU A . n 
A 1 494 SER 494 415 415 SER SER A . n 
A 1 495 ILE 495 416 416 ILE ILE A . n 
A 1 496 VAL 496 417 417 VAL VAL A . n 
A 1 497 GLY 497 418 418 GLY GLY A . n 
A 1 498 ILE 498 419 419 ILE ILE A . n 
A 1 499 LEU 499 420 420 LEU LEU A . n 
A 1 500 ALA 500 421 421 ALA ALA A . n 
A 1 501 ILE 501 422 422 ILE ILE A . n 
A 1 502 ILE 502 423 423 ILE ILE A . n 
A 1 503 ALA 503 424 424 ALA ALA A . n 
A 1 504 SER 504 425 425 SER SER A . n 
A 1 505 PHE 505 426 426 PHE PHE A . n 
A 1 506 CYS 506 427 427 CYS CYS A . n 
A 1 507 SER 507 428 428 SER SER A . n 
A 1 508 GLY 508 429 429 GLY GLY A . n 
A 1 509 PRO 509 430 430 PRO PRO A . n 
A 1 510 GLY 510 431 431 GLY GLY A . n 
A 1 511 GLY 511 432 432 GLY GLY A . n 
A 1 512 ILE 512 433 433 ILE ILE A . n 
A 1 513 PRO 513 434 434 PRO PRO A . n 
A 1 514 PHE 514 435 435 PHE PHE A . n 
A 1 515 ILE 515 436 436 ILE ILE A . n 
A 1 516 LEU 516 437 437 LEU LEU A . n 
A 1 517 THR 517 438 438 THR THR A . n 
A 1 518 GLY 518 439 439 GLY GLY A . n 
A 1 519 GLU 519 440 440 GLU GLU A . n 
A 1 520 PHE 520 441 441 PHE PHE A . n 
A 1 521 PHE 521 442 442 PHE PHE A . n 
A 1 522 GLN 522 443 443 GLN GLN A . n 
A 1 523 GLN 523 444 444 GLN GLN A . n 
A 1 524 SER 524 445 445 SER SER A . n 
A 1 525 GLN 525 446 446 GLN GLN A . n 
A 1 526 ARG 526 447 447 ARG ARG A . n 
A 1 527 PRO 527 448 448 PRO PRO A . n 
A 1 528 ALA 528 449 449 ALA ALA A . n 
A 1 529 ALA 529 450 450 ALA ALA A . n 
A 1 530 PHE 530 451 451 PHE PHE A . n 
A 1 531 ILE 531 452 452 ILE ILE A . n 
A 1 532 ILE 532 453 453 ILE ILE A . n 
A 1 533 ALA 533 454 454 ALA ALA A . n 
A 1 534 GLY 534 455 455 GLY GLY A . n 
A 1 535 THR 535 456 456 THR THR A . n 
A 1 536 VAL 536 457 457 VAL VAL A . n 
A 1 537 ASN 537 458 458 ASN ASN A . n 
A 1 538 TRP 538 459 459 TRP TRP A . n 
A 1 539 LEU 539 460 460 LEU LEU A . n 
A 1 540 SER 540 461 461 SER SER A . n 
A 1 541 ASN 541 462 462 ASN ASN A . n 
A 1 542 PHE 542 463 463 PHE PHE A . n 
A 1 543 ALA 543 464 464 ALA ALA A . n 
A 1 544 VAL 544 465 465 VAL VAL A . n 
A 1 545 GLY 545 466 466 GLY GLY A . n 
A 1 546 LEU 546 467 467 LEU LEU A . n 
A 1 547 LEU 547 468 468 LEU LEU A . n 
A 1 548 PHE 548 469 469 PHE PHE A . n 
A 1 549 PRO 549 470 470 PRO PRO A . n 
A 1 550 PHE 550 471 471 PHE PHE A . n 
A 1 551 ILE 551 472 472 ILE ILE A . n 
A 1 552 GLN 552 473 473 GLN GLN A . n 
A 1 553 LYS 553 474 474 LYS LYS A . n 
A 1 554 SER 554 475 475 SER SER A . n 
A 1 555 LEU 555 476 476 LEU LEU A . n 
A 1 556 ASP 556 477 477 ASP ASP A . n 
A 1 557 THR 557 478 478 THR THR A . n 
A 1 558 TYR 558 479 479 TYR TYR A . n 
A 1 559 CYS 559 480 480 CYS CYS A . n 
A 1 560 PHE 560 481 481 PHE PHE A . n 
A 1 561 LEU 561 482 482 LEU LEU A . n 
A 1 562 VAL 562 483 483 VAL VAL A . n 
A 1 563 PHE 563 484 484 PHE PHE A . n 
A 1 564 ALA 564 485 485 ALA ALA A . n 
A 1 565 THR 565 486 486 THR THR A . n 
A 1 566 ILE 566 487 487 ILE ILE A . n 
A 1 567 CYS 567 488 488 CYS CYS A . n 
A 1 568 ILE 568 489 489 ILE ILE A . n 
A 1 569 THR 569 490 490 THR THR A . n 
A 1 570 GLY 570 491 491 GLY GLY A . n 
A 1 571 ALA 571 492 492 ALA ALA A . n 
A 1 572 ILE 572 493 493 ILE ILE A . n 
A 1 573 TYR 573 494 494 TYR TYR A . n 
A 1 574 LEU 574 495 495 LEU LEU A . n 
A 1 575 TYR 575 496 496 TYR TYR A . n 
A 1 576 PHE 576 497 497 PHE PHE A . n 
A 1 577 VAL 577 498 498 VAL VAL A . n 
A 1 578 LEU 578 499 499 LEU LEU A . n 
A 1 579 PRO 579 500 500 PRO PRO A . n 
A 1 580 GLU 580 501 501 GLU GLU A . n 
A 1 581 THR 581 502 502 THR THR A . n 
A 1 582 LYS 582 503 503 LYS LYS A . n 
A 1 583 ASN 583 504 504 ASN ASN A . n 
A 1 584 ARG 584 505 505 ARG ARG A . n 
A 1 585 THR 585 506 506 THR THR A . n 
A 1 586 TYR 586 507 507 TYR TYR A . n 
A 1 587 ALA 587 508 508 ALA ALA A . n 
A 1 588 GLU 588 509 509 GLU GLU A . n 
A 1 589 ILE 589 510 510 ILE ILE A . n 
A 1 590 SER 590 511 511 SER SER A . n 
A 1 591 GLN 591 512 512 GLN GLN A . n 
A 1 592 ALA 592 513 513 ALA ALA A . n 
A 1 593 PHE 593 514 514 PHE PHE A . n 
A 1 594 SER 594 515 515 SER SER A . n 
A 1 595 LYS 595 516 516 LYS LYS A . n 
A 1 596 ARG 596 517 517 ARG ARG A . n 
A 1 597 ASN 597 518 518 ASN ASN A . n 
A 1 598 LYS 598 519 519 LYS LYS A . n 
A 1 599 ALA 599 520 520 ALA ALA A . n 
A 1 600 TYR 600 521 521 TYR TYR A . n 
A 1 601 PRO 601 522 522 PRO PRO A . n 
A 1 602 PRO 602 523 ?   ?   ?   A . n 
A 1 603 GLU 603 524 ?   ?   ?   A . n 
A 1 604 GLU 604 525 ?   ?   ?   A . n 
A 1 605 LYS 605 526 ?   ?   ?   A . n 
A 1 606 ILE 606 527 ?   ?   ?   A . n 
A 1 607 ASP 607 528 ?   ?   ?   A . n 
A 1 608 SER 608 529 ?   ?   ?   A . n 
A 1 609 ALA 609 530 ?   ?   ?   A . n 
A 1 610 VAL 610 531 ?   ?   ?   A . n 
A 1 611 THR 611 532 ?   ?   ?   A . n 
A 1 612 ASP 612 533 ?   ?   ?   A . n 
A 1 613 GLY 613 534 ?   ?   ?   A . n 
A 1 614 LYS 614 535 ?   ?   ?   A . n 
A 1 615 ILE 615 536 ?   ?   ?   A . n 
A 1 616 ASN 616 537 ?   ?   ?   A . n 
A 1 617 GLY 617 538 ?   ?   ?   A . n 
A 1 618 ARG 618 539 ?   ?   ?   A . n 
A 1 619 PRO 619 540 ?   ?   ?   A . n 
A 1 620 GLY 620 541 ?   ?   ?   A . n 
A 1 621 LEU 621 542 ?   ?   ?   A . n 
A 1 622 VAL 622 543 ?   ?   ?   A . n 
A 1 623 PRO 623 544 ?   ?   ?   A . n 
A 1 624 ARG 624 545 ?   ?   ?   A . n 
A 1 625 GLY 625 546 ?   ?   ?   A . n 
A 1 626 SER 626 547 ?   ?   ?   A . n 
A 1 627 SER 627 548 ?   ?   ?   A . n 
A 1 628 ALA 628 549 ?   ?   ?   A . n 
A 1 629 HIS 629 550 ?   ?   ?   A . n 
A 1 630 HIS 630 551 ?   ?   ?   A . n 
A 1 631 HIS 631 552 ?   ?   ?   A . n 
A 1 632 HIS 632 553 ?   ?   ?   A . n 
A 1 633 HIS 633 554 ?   ?   ?   A . n 
A 1 634 HIS 634 555 ?   ?   ?   A . n 
A 1 635 HIS 635 556 ?   ?   ?   A . n 
A 1 636 HIS 636 557 ?   ?   ?   A . n 
A 1 637 HIS 637 558 ?   ?   ?   A . n 
A 1 638 HIS 638 559 ?   ?   ?   A . n 
A 1 639 GLY 639 560 ?   ?   ?   A . n 
A 1 640 ALA 640 561 ?   ?   ?   A . n 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9CAX 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9CAX 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9CAX 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9CAX 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            . 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       ? 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004 ? 3702 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.922 ? 5044 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 5.059 ? 504  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.049 ? 595  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.007 ? 625  ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9CAX 
_struct.title                        'Structure of human SLC2A9 transporter' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9CAX 
_struct_keywords.text            'Transporter, MEMBRANE PROTEIN' 
_struct_keywords.pdbx_keywords   'MEMBRANE PROTEIN' 
# 
_struct_asym.id                            A 
_struct_asym.pdbx_blank_PDB_chainid_flag   N 
_struct_asym.pdbx_modified                 N 
_struct_asym.entity_id                     1 
_struct_asym.details                       ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP C562_ECOLX P0ABE7 ? 1 
;ADLEDNMETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLAN
EGKVKEAQAAAEQLKTTRNAYHQKY
;
23 
2 UNP GTR9_HUMAN Q9NRM0 ? 1 
;SCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIG
KVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIG
VFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAE
SRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSG
LVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFI
IAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVT
DGKINGRP
;
53 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9CAX A 26  ? 130 ? P0ABE7 23 ? 127 ? -53 51  
2 2 9CAX A 132 ? 619 ? Q9NRM0 53 ? 540 ? 53  540 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9CAX MET A 1   ? UNP P0ABE7 ?   ?   'expression tag' -78 1  
1 9CAX ALA A 2   ? UNP P0ABE7 ?   ?   'expression tag' -77 2  
1 9CAX SER A 3   ? UNP P0ABE7 ?   ?   'expression tag' -76 3  
1 9CAX ASP A 4   ? UNP P0ABE7 ?   ?   'expression tag' -75 4  
1 9CAX TYR A 5   ? UNP P0ABE7 ?   ?   'expression tag' -74 5  
1 9CAX LYS A 6   ? UNP P0ABE7 ?   ?   'expression tag' -73 6  
1 9CAX ASP A 7   ? UNP P0ABE7 ?   ?   'expression tag' -72 7  
1 9CAX ASP A 8   ? UNP P0ABE7 ?   ?   'expression tag' -71 8  
1 9CAX ASP A 9   ? UNP P0ABE7 ?   ?   'expression tag' -70 9  
1 9CAX ASP A 10  ? UNP P0ABE7 ?   ?   'expression tag' -69 10 
1 9CAX LYS A 11  ? UNP P0ABE7 ?   ?   'expression tag' -68 11 
1 9CAX GLY A 12  ? UNP P0ABE7 ?   ?   'expression tag' -67 12 
1 9CAX ALA A 13  ? UNP P0ABE7 ?   ?   'expression tag' -66 13 
1 9CAX LEU A 14  ? UNP P0ABE7 ?   ?   'expression tag' -65 14 
1 9CAX GLU A 15  ? UNP P0ABE7 ?   ?   'expression tag' -64 15 
1 9CAX VAL A 16  ? UNP P0ABE7 ?   ?   'expression tag' -63 16 
1 9CAX LEU A 17  ? UNP P0ABE7 ?   ?   'expression tag' -62 17 
1 9CAX PHE A 18  ? UNP P0ABE7 ?   ?   'expression tag' -61 18 
1 9CAX GLN A 19  ? UNP P0ABE7 ?   ?   'expression tag' -60 19 
1 9CAX GLY A 20  ? UNP P0ABE7 ?   ?   'expression tag' -59 20 
1 9CAX PRO A 21  ? UNP P0ABE7 ?   ?   'expression tag' -58 21 
1 9CAX SER A 22  ? UNP P0ABE7 ?   ?   'expression tag' -57 22 
1 9CAX SER A 23  ? UNP P0ABE7 ?   ?   'expression tag' -56 23 
1 9CAX PRO A 24  ? UNP P0ABE7 ?   ?   'expression tag' -55 24 
1 9CAX MET A 25  ? UNP P0ABE7 ?   ?   'expression tag' -54 25 
1 9CAX TRP A 32  ? UNP P0ABE7 MET 29  conflict         -47 26 
1 9CAX ILE A 127 ? UNP P0ABE7 HIS 124 conflict         48  27 
1 9CAX LEU A 131 ? UNP P0ABE7 ?   ?   linker           52  28 
2 9CAX GLY A 620 ? UNP Q9NRM0 ?   ?   'expression tag' 541 29 
2 9CAX LEU A 621 ? UNP Q9NRM0 ?   ?   'expression tag' 542 30 
2 9CAX VAL A 622 ? UNP Q9NRM0 ?   ?   'expression tag' 543 31 
2 9CAX PRO A 623 ? UNP Q9NRM0 ?   ?   'expression tag' 544 32 
2 9CAX ARG A 624 ? UNP Q9NRM0 ?   ?   'expression tag' 545 33 
2 9CAX GLY A 625 ? UNP Q9NRM0 ?   ?   'expression tag' 546 34 
2 9CAX SER A 626 ? UNP Q9NRM0 ?   ?   'expression tag' 547 35 
2 9CAX SER A 627 ? UNP Q9NRM0 ?   ?   'expression tag' 548 36 
2 9CAX ALA A 628 ? UNP Q9NRM0 ?   ?   'expression tag' 549 37 
2 9CAX HIS A 629 ? UNP Q9NRM0 ?   ?   'expression tag' 550 38 
2 9CAX HIS A 630 ? UNP Q9NRM0 ?   ?   'expression tag' 551 39 
2 9CAX HIS A 631 ? UNP Q9NRM0 ?   ?   'expression tag' 552 40 
2 9CAX HIS A 632 ? UNP Q9NRM0 ?   ?   'expression tag' 553 41 
2 9CAX HIS A 633 ? UNP Q9NRM0 ?   ?   'expression tag' 554 42 
2 9CAX HIS A 634 ? UNP Q9NRM0 ?   ?   'expression tag' 555 43 
2 9CAX HIS A 635 ? UNP Q9NRM0 ?   ?   'expression tag' 556 44 
2 9CAX HIS A 636 ? UNP Q9NRM0 ?   ?   'expression tag' 557 45 
2 9CAX HIS A 637 ? UNP Q9NRM0 ?   ?   'expression tag' 558 46 
2 9CAX HIS A 638 ? UNP Q9NRM0 ?   ?   'expression tag' 559 47 
2 9CAX GLY A 639 ? UNP Q9NRM0 ?   ?   'expression tag' 560 48 
2 9CAX ALA A 640 ? UNP Q9NRM0 ?   ?   'expression tag' 561 49 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 132 ? SER A 146 ? SER A 53  SER A 67  1 ? 15 
HELX_P HELX_P2  AA2 SER A 146 ? VAL A 156 ? SER A 67  VAL A 77  1 ? 11 
HELX_P HELX_P3  AA3 PRO A 160 ? ARG A 174 ? PRO A 81  ARG A 95  1 ? 15 
HELX_P HELX_P4  AA4 ASP A 181 ? GLY A 211 ? ASP A 102 GLY A 132 1 ? 31 
HELX_P HELX_P5  AA5 ARG A 216 ? CYS A 236 ? ARG A 137 CYS A 157 1 ? 21 
HELX_P HELX_P6  AA6 CYS A 236 ? GLY A 241 ? CYS A 157 GLY A 162 1 ? 6  
HELX_P HELX_P7  AA7 PHE A 243 ? SER A 272 ? PHE A 164 SER A 193 1 ? 30 
HELX_P HELX_P8  AA8 ILE A 276 ? LEU A 298 ? ILE A 197 LEU A 219 1 ? 23 
HELX_P HELX_P9  AA9 TRP A 310 ? GLY A 315 ? TRP A 231 GLY A 236 1 ? 6  
HELX_P HELX_P10 AB1 ILE A 317 ? LEU A 331 ? ILE A 238 LEU A 252 1 ? 15 
HELX_P HELX_P11 AB2 SER A 334 ? GLU A 341 ? SER A 255 GLU A 262 1 ? 8  
HELX_P HELX_P12 AB3 ASN A 344 ? GLY A 357 ? ASN A 265 GLY A 278 1 ? 14 
HELX_P HELX_P13 AB4 VAL A 361 ? ILE A 378 ? VAL A 282 ILE A 299 1 ? 18 
HELX_P HELX_P14 AB5 SER A 382 ? ALA A 389 ? SER A 303 ALA A 310 1 ? 8  
HELX_P HELX_P15 AB6 VAL A 392 ? CYS A 409 ? VAL A 313 CYS A 330 1 ? 18 
HELX_P HELX_P16 AB7 GLY A 410 ? TYR A 417 ? GLY A 331 TYR A 338 1 ? 8  
HELX_P HELX_P17 AB8 TYR A 417 ? ALA A 425 ? TYR A 338 ALA A 346 1 ? 9  
HELX_P HELX_P18 AB9 LYS A 431 ? PHE A 449 ? LYS A 352 PHE A 370 1 ? 19 
HELX_P HELX_P19 AC1 PHE A 449 ? GLY A 458 ? PHE A 370 GLY A 379 1 ? 10 
HELX_P HELX_P20 AC2 ARG A 459 ? GLN A 484 ? ARG A 380 GLN A 405 1 ? 26 
HELX_P HELX_P21 AC3 TRP A 489 ? GLY A 508 ? TRP A 410 GLY A 429 1 ? 20 
HELX_P HELX_P22 AC4 GLY A 511 ? PHE A 521 ? GLY A 432 PHE A 442 1 ? 11 
HELX_P HELX_P23 AC5 GLN A 525 ? ASP A 556 ? GLN A 446 ASP A 477 1 ? 32 
HELX_P HELX_P24 AC6 TYR A 558 ? LEU A 578 ? TYR A 479 LEU A 499 1 ? 21 
HELX_P HELX_P25 AC7 THR A 585 ? LYS A 598 ? THR A 506 LYS A 519 1 ? 14 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_pdbx_entry_details.entry_id                   9CAX 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 SER A 67  ? ? -120.10 -52.48  
2  1 PRO A 81  ? ? -84.45  41.99   
3  1 ARG A 95  ? ? -86.83  46.28   
4  1 ARG A 96  ? ? -159.17 -157.35 
5  1 LEU A 224 ? ? -93.88  -63.83  
6  1 LEU A 225 ? ? -143.96 18.83   
7  1 ALA A 346 ? ? -94.19  48.58   
8  1 PRO A 350 ? ? -69.65  -175.33 
9  1 GLN A 405 ? ? 65.53   -5.27   
10 1 PRO A 430 ? ? -67.38  7.32    
11 1 ASP A 477 ? ? 66.48   -80.30  
12 1 ASN A 504 ? ? 38.78   41.57   
13 1 ALA A 520 ? ? -102.56 77.05   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9CAX 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9CAX 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.37 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               154457 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       '4 degree cold buffer pH7.5  (300mM NaCl, 50mM Tris and 0.02% GDN)' 
_em_buffer.pH            7.5 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 
;Codon optimize SLC2A9 gene was synthesize and cloned in 83 nu yeast expressing vector from GenScript. Protein expressed in yeast cells and purified using Ni-affinity followed by Sizing.
;
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9CAX 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            OTHER 
_em_imaging.nominal_cs                      2.7 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            70 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   400 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          '30 second glow 30 sec hold' 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9CAX 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9CAX 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -78 ? A MET 1   
2   1 Y 1 A ALA -77 ? A ALA 2   
3   1 Y 1 A SER -76 ? A SER 3   
4   1 Y 1 A ASP -75 ? A ASP 4   
5   1 Y 1 A TYR -74 ? A TYR 5   
6   1 Y 1 A LYS -73 ? A LYS 6   
7   1 Y 1 A ASP -72 ? A ASP 7   
8   1 Y 1 A ASP -71 ? A ASP 8   
9   1 Y 1 A ASP -70 ? A ASP 9   
10  1 Y 1 A ASP -69 ? A ASP 10  
11  1 Y 1 A LYS -68 ? A LYS 11  
12  1 Y 1 A GLY -67 ? A GLY 12  
13  1 Y 1 A ALA -66 ? A ALA 13  
14  1 Y 1 A LEU -65 ? A LEU 14  
15  1 Y 1 A GLU -64 ? A GLU 15  
16  1 Y 1 A VAL -63 ? A VAL 16  
17  1 Y 1 A LEU -62 ? A LEU 17  
18  1 Y 1 A PHE -61 ? A PHE 18  
19  1 Y 1 A GLN -60 ? A GLN 19  
20  1 Y 1 A GLY -59 ? A GLY 20  
21  1 Y 1 A PRO -58 ? A PRO 21  
22  1 Y 1 A SER -57 ? A SER 22  
23  1 Y 1 A SER -56 ? A SER 23  
24  1 Y 1 A PRO -55 ? A PRO 24  
25  1 Y 1 A MET -54 ? A MET 25  
26  1 Y 1 A ALA -53 ? A ALA 26  
27  1 Y 1 A ASP -52 ? A ASP 27  
28  1 Y 1 A LEU -51 ? A LEU 28  
29  1 Y 1 A GLU -50 ? A GLU 29  
30  1 Y 1 A ASP -49 ? A ASP 30  
31  1 Y 1 A ASN -48 ? A ASN 31  
32  1 Y 1 A TRP -47 ? A TRP 32  
33  1 Y 1 A GLU -46 ? A GLU 33  
34  1 Y 1 A THR -45 ? A THR 34  
35  1 Y 1 A LEU -44 ? A LEU 35  
36  1 Y 1 A ASN -43 ? A ASN 36  
37  1 Y 1 A ASP -42 ? A ASP 37  
38  1 Y 1 A ASN -41 ? A ASN 38  
39  1 Y 1 A LEU -40 ? A LEU 39  
40  1 Y 1 A LYS -39 ? A LYS 40  
41  1 Y 1 A VAL -38 ? A VAL 41  
42  1 Y 1 A ILE -37 ? A ILE 42  
43  1 Y 1 A GLU -36 ? A GLU 43  
44  1 Y 1 A LYS -35 ? A LYS 44  
45  1 Y 1 A ALA -34 ? A ALA 45  
46  1 Y 1 A ASP -33 ? A ASP 46  
47  1 Y 1 A ASN -32 ? A ASN 47  
48  1 Y 1 A ALA -31 ? A ALA 48  
49  1 Y 1 A ALA -30 ? A ALA 49  
50  1 Y 1 A GLN -29 ? A GLN 50  
51  1 Y 1 A VAL -28 ? A VAL 51  
52  1 Y 1 A LYS -27 ? A LYS 52  
53  1 Y 1 A ASP -26 ? A ASP 53  
54  1 Y 1 A ALA -25 ? A ALA 54  
55  1 Y 1 A LEU -24 ? A LEU 55  
56  1 Y 1 A THR -23 ? A THR 56  
57  1 Y 1 A LYS -22 ? A LYS 57  
58  1 Y 1 A MET -21 ? A MET 58  
59  1 Y 1 A ARG -20 ? A ARG 59  
60  1 Y 1 A ALA -19 ? A ALA 60  
61  1 Y 1 A ALA -18 ? A ALA 61  
62  1 Y 1 A ALA -17 ? A ALA 62  
63  1 Y 1 A LEU -16 ? A LEU 63  
64  1 Y 1 A ASP -15 ? A ASP 64  
65  1 Y 1 A ALA -14 ? A ALA 65  
66  1 Y 1 A GLN -13 ? A GLN 66  
67  1 Y 1 A LYS -12 ? A LYS 67  
68  1 Y 1 A ALA -11 ? A ALA 68  
69  1 Y 1 A THR -10 ? A THR 69  
70  1 Y 1 A PRO -9  ? A PRO 70  
71  1 Y 1 A PRO -8  ? A PRO 71  
72  1 Y 1 A LYS -7  ? A LYS 72  
73  1 Y 1 A LEU -6  ? A LEU 73  
74  1 Y 1 A GLU -5  ? A GLU 74  
75  1 Y 1 A ASP -4  ? A ASP 75  
76  1 Y 1 A LYS -3  ? A LYS 76  
77  1 Y 1 A SER -2  ? A SER 77  
78  1 Y 1 A PRO -1  ? A PRO 78  
79  1 Y 1 A ASP 0   ? A ASP 79  
80  1 Y 1 A SER 1   ? A SER 80  
81  1 Y 1 A PRO 2   ? A PRO 81  
82  1 Y 1 A GLU 3   ? A GLU 82  
83  1 Y 1 A MET 4   ? A MET 83  
84  1 Y 1 A LYS 5   ? A LYS 84  
85  1 Y 1 A ASP 6   ? A ASP 85  
86  1 Y 1 A PHE 7   ? A PHE 86  
87  1 Y 1 A ARG 8   ? A ARG 87  
88  1 Y 1 A HIS 9   ? A HIS 88  
89  1 Y 1 A GLY 10  ? A GLY 89  
90  1 Y 1 A PHE 11  ? A PHE 90  
91  1 Y 1 A ASP 12  ? A ASP 91  
92  1 Y 1 A ILE 13  ? A ILE 92  
93  1 Y 1 A LEU 14  ? A LEU 93  
94  1 Y 1 A VAL 15  ? A VAL 94  
95  1 Y 1 A GLY 16  ? A GLY 95  
96  1 Y 1 A GLN 17  ? A GLN 96  
97  1 Y 1 A ILE 18  ? A ILE 97  
98  1 Y 1 A ASP 19  ? A ASP 98  
99  1 Y 1 A ASP 20  ? A ASP 99  
100 1 Y 1 A ALA 21  ? A ALA 100 
101 1 Y 1 A LEU 22  ? A LEU 101 
102 1 Y 1 A LYS 23  ? A LYS 102 
103 1 Y 1 A LEU 24  ? A LEU 103 
104 1 Y 1 A ALA 25  ? A ALA 104 
105 1 Y 1 A ASN 26  ? A ASN 105 
106 1 Y 1 A GLU 27  ? A GLU 106 
107 1 Y 1 A GLY 28  ? A GLY 107 
108 1 Y 1 A LYS 29  ? A LYS 108 
109 1 Y 1 A VAL 30  ? A VAL 109 
110 1 Y 1 A LYS 31  ? A LYS 110 
111 1 Y 1 A GLU 32  ? A GLU 111 
112 1 Y 1 A ALA 33  ? A ALA 112 
113 1 Y 1 A GLN 34  ? A GLN 113 
114 1 Y 1 A ALA 35  ? A ALA 114 
115 1 Y 1 A ALA 36  ? A ALA 115 
116 1 Y 1 A ALA 37  ? A ALA 116 
117 1 Y 1 A GLU 38  ? A GLU 117 
118 1 Y 1 A GLN 39  ? A GLN 118 
119 1 Y 1 A LEU 40  ? A LEU 119 
120 1 Y 1 A LYS 41  ? A LYS 120 
121 1 Y 1 A THR 42  ? A THR 121 
122 1 Y 1 A THR 43  ? A THR 122 
123 1 Y 1 A ARG 44  ? A ARG 123 
124 1 Y 1 A ASN 45  ? A ASN 124 
125 1 Y 1 A ALA 46  ? A ALA 125 
126 1 Y 1 A TYR 47  ? A TYR 126 
127 1 Y 1 A ILE 48  ? A ILE 127 
128 1 Y 1 A GLN 49  ? A GLN 128 
129 1 Y 1 A LYS 50  ? A LYS 129 
130 1 Y 1 A TYR 51  ? A TYR 130 
131 1 Y 1 A LEU 52  ? A LEU 131 
132 1 Y 1 A PRO 523 ? A PRO 602 
133 1 Y 1 A GLU 524 ? A GLU 603 
134 1 Y 1 A GLU 525 ? A GLU 604 
135 1 Y 1 A LYS 526 ? A LYS 605 
136 1 Y 1 A ILE 527 ? A ILE 606 
137 1 Y 1 A ASP 528 ? A ASP 607 
138 1 Y 1 A SER 529 ? A SER 608 
139 1 Y 1 A ALA 530 ? A ALA 609 
140 1 Y 1 A VAL 531 ? A VAL 610 
141 1 Y 1 A THR 532 ? A THR 611 
142 1 Y 1 A ASP 533 ? A ASP 612 
143 1 Y 1 A GLY 534 ? A GLY 613 
144 1 Y 1 A LYS 535 ? A LYS 614 
145 1 Y 1 A ILE 536 ? A ILE 615 
146 1 Y 1 A ASN 537 ? A ASN 616 
147 1 Y 1 A GLY 538 ? A GLY 617 
148 1 Y 1 A ARG 539 ? A ARG 618 
149 1 Y 1 A PRO 540 ? A PRO 619 
150 1 Y 1 A GLY 541 ? A GLY 620 
151 1 Y 1 A LEU 542 ? A LEU 621 
152 1 Y 1 A VAL 543 ? A VAL 622 
153 1 Y 1 A PRO 544 ? A PRO 623 
154 1 Y 1 A ARG 545 ? A ARG 624 
155 1 Y 1 A GLY 546 ? A GLY 625 
156 1 Y 1 A SER 547 ? A SER 626 
157 1 Y 1 A SER 548 ? A SER 627 
158 1 Y 1 A ALA 549 ? A ALA 628 
159 1 Y 1 A HIS 550 ? A HIS 629 
160 1 Y 1 A HIS 551 ? A HIS 630 
161 1 Y 1 A HIS 552 ? A HIS 631 
162 1 Y 1 A HIS 553 ? A HIS 632 
163 1 Y 1 A HIS 554 ? A HIS 633 
164 1 Y 1 A HIS 555 ? A HIS 634 
165 1 Y 1 A HIS 556 ? A HIS 635 
166 1 Y 1 A HIS 557 ? A HIS 636 
167 1 Y 1 A HIS 558 ? A HIS 637 
168 1 Y 1 A HIS 559 ? A HIS 638 
169 1 Y 1 A GLY 560 ? A GLY 639 
170 1 Y 1 A ALA 561 ? A ALA 640 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
ILE N    N N N 158 
ILE CA   C N S 159 
ILE C    C N N 160 
ILE O    O N N 161 
ILE CB   C N S 162 
ILE CG1  C N N 163 
ILE CG2  C N N 164 
ILE CD1  C N N 165 
ILE OXT  O N N 166 
ILE H    H N N 167 
ILE H2   H N N 168 
ILE HA   H N N 169 
ILE HB   H N N 170 
ILE HG12 H N N 171 
ILE HG13 H N N 172 
ILE HG21 H N N 173 
ILE HG22 H N N 174 
ILE HG23 H N N 175 
ILE HD11 H N N 176 
ILE HD12 H N N 177 
ILE HD13 H N N 178 
ILE HXT  H N N 179 
LEU N    N N N 180 
LEU CA   C N S 181 
LEU C    C N N 182 
LEU O    O N N 183 
LEU CB   C N N 184 
LEU CG   C N N 185 
LEU CD1  C N N 186 
LEU CD2  C N N 187 
LEU OXT  O N N 188 
LEU H    H N N 189 
LEU H2   H N N 190 
LEU HA   H N N 191 
LEU HB2  H N N 192 
LEU HB3  H N N 193 
LEU HG   H N N 194 
LEU HD11 H N N 195 
LEU HD12 H N N 196 
LEU HD13 H N N 197 
LEU HD21 H N N 198 
LEU HD22 H N N 199 
LEU HD23 H N N 200 
LEU HXT  H N N 201 
LYS N    N N N 202 
LYS CA   C N S 203 
LYS C    C N N 204 
LYS O    O N N 205 
LYS CB   C N N 206 
LYS CG   C N N 207 
LYS CD   C N N 208 
LYS CE   C N N 209 
LYS NZ   N N N 210 
LYS OXT  O N N 211 
LYS H    H N N 212 
LYS H2   H N N 213 
LYS HA   H N N 214 
LYS HB2  H N N 215 
LYS HB3  H N N 216 
LYS HG2  H N N 217 
LYS HG3  H N N 218 
LYS HD2  H N N 219 
LYS HD3  H N N 220 
LYS HE2  H N N 221 
LYS HE3  H N N 222 
LYS HZ1  H N N 223 
LYS HZ2  H N N 224 
LYS HZ3  H N N 225 
LYS HXT  H N N 226 
MET N    N N N 227 
MET CA   C N S 228 
MET C    C N N 229 
MET O    O N N 230 
MET CB   C N N 231 
MET CG   C N N 232 
MET SD   S N N 233 
MET CE   C N N 234 
MET OXT  O N N 235 
MET H    H N N 236 
MET H2   H N N 237 
MET HA   H N N 238 
MET HB2  H N N 239 
MET HB3  H N N 240 
MET HG2  H N N 241 
MET HG3  H N N 242 
MET HE1  H N N 243 
MET HE2  H N N 244 
MET HE3  H N N 245 
MET HXT  H N N 246 
PHE N    N N N 247 
PHE CA   C N S 248 
PHE C    C N N 249 
PHE O    O N N 250 
PHE CB   C N N 251 
PHE CG   C Y N 252 
PHE CD1  C Y N 253 
PHE CD2  C Y N 254 
PHE CE1  C Y N 255 
PHE CE2  C Y N 256 
PHE CZ   C Y N 257 
PHE OXT  O N N 258 
PHE H    H N N 259 
PHE H2   H N N 260 
PHE HA   H N N 261 
PHE HB2  H N N 262 
PHE HB3  H N N 263 
PHE HD1  H N N 264 
PHE HD2  H N N 265 
PHE HE1  H N N 266 
PHE HE2  H N N 267 
PHE HZ   H N N 268 
PHE HXT  H N N 269 
PRO N    N N N 270 
PRO CA   C N S 271 
PRO C    C N N 272 
PRO O    O N N 273 
PRO CB   C N N 274 
PRO CG   C N N 275 
PRO CD   C N N 276 
PRO OXT  O N N 277 
PRO H    H N N 278 
PRO HA   H N N 279 
PRO HB2  H N N 280 
PRO HB3  H N N 281 
PRO HG2  H N N 282 
PRO HG3  H N N 283 
PRO HD2  H N N 284 
PRO HD3  H N N 285 
PRO HXT  H N N 286 
SER N    N N N 287 
SER CA   C N S 288 
SER C    C N N 289 
SER O    O N N 290 
SER CB   C N N 291 
SER OG   O N N 292 
SER OXT  O N N 293 
SER H    H N N 294 
SER H2   H N N 295 
SER HA   H N N 296 
SER HB2  H N N 297 
SER HB3  H N N 298 
SER HG   H N N 299 
SER HXT  H N N 300 
THR N    N N N 301 
THR CA   C N S 302 
THR C    C N N 303 
THR O    O N N 304 
THR CB   C N R 305 
THR OG1  O N N 306 
THR CG2  C N N 307 
THR OXT  O N N 308 
THR H    H N N 309 
THR H2   H N N 310 
THR HA   H N N 311 
THR HB   H N N 312 
THR HG1  H N N 313 
THR HG21 H N N 314 
THR HG22 H N N 315 
THR HG23 H N N 316 
THR HXT  H N N 317 
TRP N    N N N 318 
TRP CA   C N S 319 
TRP C    C N N 320 
TRP O    O N N 321 
TRP CB   C N N 322 
TRP CG   C Y N 323 
TRP CD1  C Y N 324 
TRP CD2  C Y N 325 
TRP NE1  N Y N 326 
TRP CE2  C Y N 327 
TRP CE3  C Y N 328 
TRP CZ2  C Y N 329 
TRP CZ3  C Y N 330 
TRP CH2  C Y N 331 
TRP OXT  O N N 332 
TRP H    H N N 333 
TRP H2   H N N 334 
TRP HA   H N N 335 
TRP HB2  H N N 336 
TRP HB3  H N N 337 
TRP HD1  H N N 338 
TRP HE1  H N N 339 
TRP HE3  H N N 340 
TRP HZ2  H N N 341 
TRP HZ3  H N N 342 
TRP HH2  H N N 343 
TRP HXT  H N N 344 
TYR N    N N N 345 
TYR CA   C N S 346 
TYR C    C N N 347 
TYR O    O N N 348 
TYR CB   C N N 349 
TYR CG   C Y N 350 
TYR CD1  C Y N 351 
TYR CD2  C Y N 352 
TYR CE1  C Y N 353 
TYR CE2  C Y N 354 
TYR CZ   C Y N 355 
TYR OH   O N N 356 
TYR OXT  O N N 357 
TYR H    H N N 358 
TYR H2   H N N 359 
TYR HA   H N N 360 
TYR HB2  H N N 361 
TYR HB3  H N N 362 
TYR HD1  H N N 363 
TYR HD2  H N N 364 
TYR HE1  H N N 365 
TYR HE2  H N N 366 
TYR HH   H N N 367 
TYR HXT  H N N 368 
VAL N    N N N 369 
VAL CA   C N S 370 
VAL C    C N N 371 
VAL O    O N N 372 
VAL CB   C N N 373 
VAL CG1  C N N 374 
VAL CG2  C N N 375 
VAL OXT  O N N 376 
VAL H    H N N 377 
VAL H2   H N N 378 
VAL HA   H N N 379 
VAL HB   H N N 380 
VAL HG11 H N N 381 
VAL HG12 H N N 382 
VAL HG13 H N N 383 
VAL HG21 H N N 384 
VAL HG22 H N N 385 
VAL HG23 H N N 386 
VAL HXT  H N N 387 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PRO N   CA   sing N N 258 
PRO N   CD   sing N N 259 
PRO N   H    sing N N 260 
PRO CA  C    sing N N 261 
PRO CA  CB   sing N N 262 
PRO CA  HA   sing N N 263 
PRO C   O    doub N N 264 
PRO C   OXT  sing N N 265 
PRO CB  CG   sing N N 266 
PRO CB  HB2  sing N N 267 
PRO CB  HB3  sing N N 268 
PRO CG  CD   sing N N 269 
PRO CG  HG2  sing N N 270 
PRO CG  HG3  sing N N 271 
PRO CD  HD2  sing N N 272 
PRO CD  HD3  sing N N 273 
PRO OXT HXT  sing N N 274 
SER N   CA   sing N N 275 
SER N   H    sing N N 276 
SER N   H2   sing N N 277 
SER CA  C    sing N N 278 
SER CA  CB   sing N N 279 
SER CA  HA   sing N N 280 
SER C   O    doub N N 281 
SER C   OXT  sing N N 282 
SER CB  OG   sing N N 283 
SER CB  HB2  sing N N 284 
SER CB  HB3  sing N N 285 
SER OG  HG   sing N N 286 
SER OXT HXT  sing N N 287 
THR N   CA   sing N N 288 
THR N   H    sing N N 289 
THR N   H2   sing N N 290 
THR CA  C    sing N N 291 
THR CA  CB   sing N N 292 
THR CA  HA   sing N N 293 
THR C   O    doub N N 294 
THR C   OXT  sing N N 295 
THR CB  OG1  sing N N 296 
THR CB  CG2  sing N N 297 
THR CB  HB   sing N N 298 
THR OG1 HG1  sing N N 299 
THR CG2 HG21 sing N N 300 
THR CG2 HG22 sing N N 301 
THR CG2 HG23 sing N N 302 
THR OXT HXT  sing N N 303 
TRP N   CA   sing N N 304 
TRP N   H    sing N N 305 
TRP N   H2   sing N N 306 
TRP CA  C    sing N N 307 
TRP CA  CB   sing N N 308 
TRP CA  HA   sing N N 309 
TRP C   O    doub N N 310 
TRP C   OXT  sing N N 311 
TRP CB  CG   sing N N 312 
TRP CB  HB2  sing N N 313 
TRP CB  HB3  sing N N 314 
TRP CG  CD1  doub Y N 315 
TRP CG  CD2  sing Y N 316 
TRP CD1 NE1  sing Y N 317 
TRP CD1 HD1  sing N N 318 
TRP CD2 CE2  doub Y N 319 
TRP CD2 CE3  sing Y N 320 
TRP NE1 CE2  sing Y N 321 
TRP NE1 HE1  sing N N 322 
TRP CE2 CZ2  sing Y N 323 
TRP CE3 CZ3  doub Y N 324 
TRP CE3 HE3  sing N N 325 
TRP CZ2 CH2  doub Y N 326 
TRP CZ2 HZ2  sing N N 327 
TRP CZ3 CH2  sing Y N 328 
TRP CZ3 HZ3  sing N N 329 
TRP CH2 HH2  sing N N 330 
TRP OXT HXT  sing N N 331 
TYR N   CA   sing N N 332 
TYR N   H    sing N N 333 
TYR N   H2   sing N N 334 
TYR CA  C    sing N N 335 
TYR CA  CB   sing N N 336 
TYR CA  HA   sing N N 337 
TYR C   O    doub N N 338 
TYR C   OXT  sing N N 339 
TYR CB  CG   sing N N 340 
TYR CB  HB2  sing N N 341 
TYR CB  HB3  sing N N 342 
TYR CG  CD1  doub Y N 343 
TYR CG  CD2  sing Y N 344 
TYR CD1 CE1  sing Y N 345 
TYR CD1 HD1  sing N N 346 
TYR CD2 CE2  doub Y N 347 
TYR CD2 HD2  sing N N 348 
TYR CE1 CZ   doub Y N 349 
TYR CE1 HE1  sing N N 350 
TYR CE2 CZ   sing Y N 351 
TYR CE2 HE2  sing N N 352 
TYR CZ  OH   sing N N 353 
TYR OH  HH   sing N N 354 
TYR OXT HXT  sing N N 355 
VAL N   CA   sing N N 356 
VAL N   H    sing N N 357 
VAL N   H2   sing N N 358 
VAL CA  C    sing N N 359 
VAL CA  CB   sing N N 360 
VAL CA  HA   sing N N 361 
VAL C   O    doub N N 362 
VAL C   OXT  sing N N 363 
VAL CB  CG1  sing N N 364 
VAL CB  CG2  sing N N 365 
VAL CB  HB   sing N N 366 
VAL CG1 HG11 sing N N 367 
VAL CG1 HG12 sing N N 368 
VAL CG1 HG13 sing N N 369 
VAL CG2 HG21 sing N N 370 
VAL CG2 HG22 sing N N 371 
VAL CG2 HG23 sing N N 372 
VAL OXT HXT  sing N N 373 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-06-18 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9CAX 
_em_admin.last_update        2025-05-28 
_em_admin.map_release_date   2025-01-29 
_em_admin.title              'Structure of human SLC2A9 transporter' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 300 mM NaCl    1 'Sodium Chloride' 
1 50  mM Tris-Cl 2 Tris              
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                0.06978906 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens (Human)' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          4932 
_em_entity_assembly_recombinant.organism             'Saccharomyces cerevisiae' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               2 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         47.7 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    1 
_em_image_recording.num_real_images                     10503 
# 
_em_particle_selection.details                  ? 
_em_particle_selection.id                       1 
_em_particle_selection.image_processing_id      1 
_em_particle_selection.method                   ? 
_em_particle_selection.num_particles_selected   9590974 
_em_particle_selection.reference_model          ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? cryoSPARC ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ?         ? 
MASKING                         ? 3  ? ? ? ?         ? 
'CTF CORRECTION'                ? 4  1 ? ? ?         ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ?         ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?         ? 
'MODEL FITTING'                 ? 7  ? ? ? ?         ? 
'MODEL REFINEMENT'              ? 8  ? ? ? PHENIX    ? 
OTHER                           ? 9  ? ? ? ?         ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?         ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?         ? 
CLASSIFICATION                  ? 12 1 ? ? ?         ? 
RECONSTRUCTION                  ? 13 1 ? ? ?         ? 
'VOLUME SELECTION'              ? 14 1 1 1 ?         ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ?         ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?         ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?         ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?         ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?         ? 
# 
_em_specimen.concentration           7 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9CAX 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM 1    N N   . SER A 1 132 ? 166.625 128.645 159.778 1.00 121.98 ? 53  SER A N   1 
ATOM 2    C CA  . SER A 1 132 ? 166.353 129.566 160.875 1.00 129.62 ? 53  SER A CA  1 
ATOM 3    C C   . SER A 1 132 ? 164.868 129.590 161.213 1.00 129.29 ? 53  SER A C   1 
ATOM 4    O O   . SER A 1 132 ? 164.077 130.220 160.512 1.00 125.93 ? 53  SER A O   1 
ATOM 5    C CB  . SER A 1 132 ? 166.833 130.976 160.525 1.00 129.22 ? 53  SER A CB  1 
ATOM 6    O OG  . SER A 1 132 ? 166.313 131.930 161.433 1.00 127.49 ? 53  SER A OG  1 
ATOM 7    N N   . CYS A 1 133 ? 164.499 128.895 162.294 1.00 131.13 ? 54  CYS A N   1 
ATOM 8    C CA  . CYS A 1 133 ? 163.098 128.826 162.698 1.00 128.34 ? 54  CYS A CA  1 
ATOM 9    C C   . CYS A 1 133 ? 162.583 130.169 163.200 1.00 125.74 ? 54  CYS A C   1 
ATOM 10   O O   . CYS A 1 133 ? 161.392 130.468 163.052 1.00 122.33 ? 54  CYS A O   1 
ATOM 11   C CB  . CYS A 1 133 ? 162.914 127.754 163.772 1.00 129.13 ? 54  CYS A CB  1 
ATOM 12   S SG  . CYS A 1 133 ? 163.254 126.071 163.208 1.00 141.45 ? 54  CYS A SG  1 
ATOM 13   N N   . SER A 1 134 ? 163.456 130.985 163.797 1.00 126.45 ? 55  SER A N   1 
ATOM 14   C CA  . SER A 1 134 ? 163.048 132.296 164.286 1.00 124.18 ? 55  SER A CA  1 
ATOM 15   C C   . SER A 1 134 ? 162.733 133.269 163.156 1.00 120.83 ? 55  SER A C   1 
ATOM 16   O O   . SER A 1 134 ? 162.000 134.238 163.376 1.00 115.40 ? 55  SER A O   1 
ATOM 17   C CB  . SER A 1 134 ? 164.136 132.880 165.186 1.00 125.59 ? 55  SER A CB  1 
ATOM 18   O OG  . SER A 1 134 ? 165.422 132.580 164.675 1.00 125.94 ? 55  SER A OG  1 
ATOM 19   N N   . LEU A 1 135 ? 163.283 133.045 161.962 1.00 122.24 ? 56  LEU A N   1 
ATOM 20   C CA  . LEU A 1 135 ? 162.975 133.910 160.830 1.00 120.30 ? 56  LEU A CA  1 
ATOM 21   C C   . LEU A 1 135 ? 161.605 133.605 160.236 1.00 117.79 ? 56  LEU A C   1 
ATOM 22   O O   . LEU A 1 135 ? 160.923 134.523 159.763 1.00 114.97 ? 56  LEU A O   1 
ATOM 23   C CB  . LEU A 1 135 ? 164.065 133.778 159.763 1.00 120.98 ? 56  LEU A CB  1 
ATOM 24   C CG  . LEU A 1 135 ? 163.903 134.558 158.457 1.00 117.92 ? 56  LEU A CG  1 
ATOM 25   C CD1 . LEU A 1 135 ? 163.905 136.053 158.729 1.00 115.13 ? 56  LEU A CD1 1 
ATOM 26   C CD2 . LEU A 1 135 ? 164.998 134.188 157.470 1.00 117.44 ? 56  LEU A CD2 1 
ATOM 27   N N   . LEU A 1 136 ? 161.187 132.334 160.256 1.00 118.21 ? 57  LEU A N   1 
ATOM 28   C CA  . LEU A 1 136 ? 159.899 131.959 159.676 1.00 115.43 ? 57  LEU A CA  1 
ATOM 29   C C   . LEU A 1 136 ? 158.736 132.569 160.449 1.00 109.95 ? 57  LEU A C   1 
ATOM 30   O O   . LEU A 1 136 ? 157.773 133.057 159.847 1.00 107.70 ? 57  LEU A O   1 
ATOM 31   C CB  . LEU A 1 136 ? 159.759 130.436 159.628 1.00 117.45 ? 57  LEU A CB  1 
ATOM 32   C CG  . LEU A 1 136 ? 161.010 129.570 159.476 1.00 118.42 ? 57  LEU A CG  1 
ATOM 33   C CD1 . LEU A 1 136 ? 160.656 128.103 159.643 1.00 119.67 ? 57  LEU A CD1 1 
ATOM 34   C CD2 . LEU A 1 136 ? 161.670 129.801 158.124 1.00 118.58 ? 57  LEU A CD2 1 
ATOM 35   N N   . VAL A 1 137 ? 158.805 132.546 161.782 1.00 109.30 ? 58  VAL A N   1 
ATOM 36   C CA  . VAL A 1 137 ? 157.727 133.104 162.595 1.00 108.24 ? 58  VAL A CA  1 
ATOM 37   C C   . VAL A 1 137 ? 157.687 134.625 162.462 1.00 107.25 ? 58  VAL A C   1 
ATOM 38   O O   . VAL A 1 137 ? 156.608 135.227 162.405 1.00 108.71 ? 58  VAL A O   1 
ATOM 39   C CB  . VAL A 1 137 ? 157.873 132.640 164.060 1.00 111.45 ? 58  VAL A CB  1 
ATOM 40   C CG1 . VAL A 1 137 ? 159.307 132.787 164.546 1.00 114.01 ? 58  VAL A CG1 1 
ATOM 41   C CG2 . VAL A 1 137 ? 156.905 133.374 164.985 1.00 108.02 ? 58  VAL A CG2 1 
ATOM 42   N N   . ALA A 1 138 ? 158.858 135.265 162.380 1.00 106.33 ? 59  ALA A N   1 
ATOM 43   C CA  . ALA A 1 138 ? 158.909 136.717 162.226 1.00 102.78 ? 59  ALA A CA  1 
ATOM 44   C C   . ALA A 1 138 ? 158.342 137.160 160.882 1.00 103.91 ? 59  ALA A C   1 
ATOM 45   O O   . ALA A 1 138 ? 157.632 138.170 160.806 1.00 98.52  ? 59  ALA A O   1 
ATOM 46   C CB  . ALA A 1 138 ? 160.345 137.211 162.390 1.00 106.26 ? 59  ALA A CB  1 
ATOM 47   N N   . SER A 1 139 ? 158.644 136.420 159.814 1.00 105.99 ? 60  SER A N   1 
ATOM 48   C CA  . SER A 1 139 ? 158.152 136.796 158.493 1.00 101.20 ? 60  SER A CA  1 
ATOM 49   C C   . SER A 1 139 ? 156.665 136.500 158.344 1.00 99.78  ? 60  SER A C   1 
ATOM 50   O O   . SER A 1 139 ? 155.926 137.296 157.753 1.00 97.55  ? 60  SER A O   1 
ATOM 51   C CB  . SER A 1 139 ? 158.953 136.073 157.413 1.00 99.59  ? 60  SER A CB  1 
ATOM 52   O OG  . SER A 1 139 ? 159.261 134.749 157.811 1.00 101.82 ? 60  SER A OG  1 
ATOM 53   N N   . LEU A 1 140 ? 156.210 135.354 158.860 1.00 101.36 ? 61  LEU A N   1 
ATOM 54   C CA  . LEU A 1 140 ? 154.809 134.972 158.708 1.00 96.28  ? 61  LEU A CA  1 
ATOM 55   C C   . LEU A 1 140 ? 153.895 135.862 159.541 1.00 89.64  ? 61  LEU A C   1 
ATOM 56   O O   . LEU A 1 140 ? 152.895 136.386 159.038 1.00 83.99  ? 61  LEU A O   1 
ATOM 57   C CB  . LEU A 1 140 ? 154.621 133.505 159.093 1.00 97.04  ? 61  LEU A CB  1 
ATOM 58   C CG  . LEU A 1 140 ? 154.810 132.473 157.981 1.00 95.98  ? 61  LEU A CG  1 
ATOM 59   C CD1 . LEU A 1 140 ? 154.755 131.061 158.544 1.00 97.52  ? 61  LEU A CD1 1 
ATOM 60   C CD2 . LEU A 1 140 ? 153.769 132.660 156.891 1.00 93.19  ? 61  LEU A CD2 1 
ATOM 61   N N   . ALA A 1 141 ? 154.226 136.052 160.819 1.00 92.84  ? 62  ALA A N   1 
ATOM 62   C CA  . ALA A 1 141 ? 153.375 136.847 161.696 1.00 89.87  ? 62  ALA A CA  1 
ATOM 63   C C   . ALA A 1 141 ? 153.509 138.339 161.431 1.00 83.50  ? 62  ALA A C   1 
ATOM 64   O O   . ALA A 1 141 ? 152.576 139.099 161.715 1.00 80.04  ? 62  ALA A O   1 
ATOM 65   C CB  . ALA A 1 141 ? 153.693 136.543 163.158 1.00 92.32  ? 62  ALA A CB  1 
ATOM 66   N N   . GLY A 1 142 ? 154.658 138.779 160.915 1.00 84.71  ? 63  GLY A N   1 
ATOM 67   C CA  . GLY A 1 142 ? 154.800 140.175 160.540 1.00 82.84  ? 63  GLY A CA  1 
ATOM 68   C C   . GLY A 1 142 ? 153.904 140.557 159.378 1.00 77.32  ? 63  GLY A C   1 
ATOM 69   O O   . GLY A 1 142 ? 153.292 141.628 159.380 1.00 74.61  ? 63  GLY A O   1 
ATOM 70   N N   . ALA A 1 143 ? 153.812 139.686 158.373 1.00 77.21  ? 64  ALA A N   1 
ATOM 71   C CA  . ALA A 1 143 ? 152.944 139.947 157.232 1.00 73.49  ? 64  ALA A CA  1 
ATOM 72   C C   . ALA A 1 143 ? 151.478 139.685 157.549 1.00 71.95  ? 64  ALA A C   1 
ATOM 73   O O   . ALA A 1 143 ? 150.600 140.310 156.944 1.00 69.64  ? 64  ALA A O   1 
ATOM 74   C CB  . ALA A 1 143 ? 153.383 139.104 156.036 1.00 71.84  ? 64  ALA A CB  1 
ATOM 75   N N   . PHE A 1 144 ? 151.193 138.769 158.480 1.00 72.66  ? 65  PHE A N   1 
ATOM 76   C CA  . PHE A 1 144 ? 149.808 138.432 158.794 1.00 66.02  ? 65  PHE A CA  1 
ATOM 77   C C   . PHE A 1 144 ? 149.102 139.565 159.530 1.00 62.95  ? 65  PHE A C   1 
ATOM 78   O O   . PHE A 1 144 ? 147.877 139.689 159.444 1.00 61.34  ? 65  PHE A O   1 
ATOM 79   C CB  . PHE A 1 144 ? 149.753 137.148 159.624 1.00 65.04  ? 65  PHE A CB  1 
ATOM 80   C CG  . PHE A 1 144 ? 148.358 136.713 159.983 1.00 61.14  ? 65  PHE A CG  1 
ATOM 81   C CD1 . PHE A 1 144 ? 147.380 136.594 159.008 1.00 61.43  ? 65  PHE A CD1 1 
ATOM 82   C CD2 . PHE A 1 144 ? 148.022 136.440 161.298 1.00 61.53  ? 65  PHE A CD2 1 
ATOM 83   C CE1 . PHE A 1 144 ? 146.096 136.201 159.337 1.00 56.89  ? 65  PHE A CE1 1 
ATOM 84   C CE2 . PHE A 1 144 ? 146.739 136.047 161.634 1.00 59.40  ? 65  PHE A CE2 1 
ATOM 85   C CZ  . PHE A 1 144 ? 145.776 135.928 160.652 1.00 56.71  ? 65  PHE A CZ  1 
ATOM 86   N N   . GLY A 1 145 ? 149.842 140.398 160.250 1.00 67.38  ? 66  GLY A N   1 
ATOM 87   C CA  . GLY A 1 145 ? 149.205 141.449 161.016 1.00 67.72  ? 66  GLY A CA  1 
ATOM 88   C C   . GLY A 1 145 ? 149.050 142.754 160.266 1.00 65.17  ? 66  GLY A C   1 
ATOM 89   O O   . GLY A 1 145 ? 148.110 143.512 160.523 1.00 65.13  ? 66  GLY A O   1 
ATOM 90   N N   . SER A 1 146 ? 149.962 143.033 159.338 1.00 63.86  ? 67  SER A N   1 
ATOM 91   C CA  . SER A 1 146 ? 150.008 144.333 158.684 1.00 61.50  ? 67  SER A CA  1 
ATOM 92   C C   . SER A 1 146 ? 149.828 144.261 157.175 1.00 60.11  ? 67  SER A C   1 
ATOM 93   O O   . SER A 1 146 ? 148.974 144.967 156.627 1.00 57.08  ? 67  SER A O   1 
ATOM 94   C CB  . SER A 1 146 ? 151.329 145.027 159.037 1.00 65.57  ? 67  SER A CB  1 
ATOM 95   O OG  . SER A 1 146 ? 152.385 144.534 158.244 1.00 63.63  ? 67  SER A OG  1 
ATOM 96   N N   . SER A 1 147 ? 150.613 143.433 156.477 1.00 61.88  ? 68  SER A N   1 
ATOM 97   C CA  . SER A 1 147 ? 150.471 143.333 155.025 1.00 56.62  ? 68  SER A CA  1 
ATOM 98   C C   . SER A 1 147 ? 149.224 142.554 154.628 1.00 53.69  ? 68  SER A C   1 
ATOM 99   O O   . SER A 1 147 ? 148.665 142.790 153.551 1.00 49.83  ? 68  SER A O   1 
ATOM 100  C CB  . SER A 1 147 ? 151.709 142.684 154.410 1.00 56.61  ? 68  SER A CB  1 
ATOM 101  O OG  . SER A 1 147 ? 152.698 143.654 154.118 1.00 65.17  ? 68  SER A OG  1 
ATOM 102  N N   . PHE A 1 148 ? 148.797 141.610 155.468 1.00 58.55  ? 69  PHE A N   1 
ATOM 103  C CA  . PHE A 1 148 ? 147.542 140.902 155.240 1.00 52.56  ? 69  PHE A CA  1 
ATOM 104  C C   . PHE A 1 148 ? 146.358 141.860 155.294 1.00 49.24  ? 69  PHE A C   1 
ATOM 105  O O   . PHE A 1 148 ? 145.434 141.764 154.478 1.00 45.45  ? 69  PHE A O   1 
ATOM 106  C CB  . PHE A 1 148 ? 147.408 139.789 156.284 1.00 55.62  ? 69  PHE A CB  1 
ATOM 107  C CG  . PHE A 1 148 ? 146.272 138.824 156.051 1.00 52.43  ? 69  PHE A CG  1 
ATOM 108  C CD1 . PHE A 1 148 ? 144.972 139.137 156.425 1.00 50.34  ? 69  PHE A CD1 1 
ATOM 109  C CD2 . PHE A 1 148 ? 146.519 137.580 155.500 1.00 53.17  ? 69  PHE A CD2 1 
ATOM 110  C CE1 . PHE A 1 148 ? 143.945 138.242 156.224 1.00 51.81  ? 69  PHE A CE1 1 
ATOM 111  C CE2 . PHE A 1 148 ? 145.495 136.682 155.300 1.00 50.57  ? 69  PHE A CE2 1 
ATOM 112  C CZ  . PHE A 1 148 ? 144.209 137.013 155.662 1.00 50.00  ? 69  PHE A CZ  1 
ATOM 113  N N   . LEU A 1 149 ? 146.369 142.791 156.250 1.00 54.31  ? 70  LEU A N   1 
ATOM 114  C CA  . LEU A 1 149 ? 145.217 143.656 156.464 1.00 49.01  ? 70  LEU A CA  1 
ATOM 115  C C   . LEU A 1 149 ? 145.063 144.712 155.379 1.00 50.67  ? 70  LEU A C   1 
ATOM 116  O O   . LEU A 1 149 ? 143.955 145.225 155.190 1.00 49.88  ? 70  LEU A O   1 
ATOM 117  C CB  . LEU A 1 149 ? 145.312 144.323 157.835 1.00 46.19  ? 70  LEU A CB  1 
ATOM 118  C CG  . LEU A 1 149 ? 144.715 143.486 158.965 1.00 47.20  ? 70  LEU A CG  1 
ATOM 119  C CD1 . LEU A 1 149 ? 144.843 144.197 160.301 1.00 46.39  ? 70  LEU A CD1 1 
ATOM 120  C CD2 . LEU A 1 149 ? 143.268 143.145 158.661 1.00 47.85  ? 70  LEU A CD2 1 
ATOM 121  N N   . TYR A 1 150 ? 146.142 145.065 154.678 1.00 51.59  ? 71  TYR A N   1 
ATOM 122  C CA  . TYR A 1 150 ? 146.001 145.927 153.509 1.00 47.98  ? 71  TYR A CA  1 
ATOM 123  C C   . TYR A 1 150 ? 145.265 145.206 152.390 1.00 45.88  ? 71  TYR A C   1 
ATOM 124  O O   . TYR A 1 150 ? 144.357 145.768 151.768 1.00 48.24  ? 71  TYR A O   1 
ATOM 125  C CB  . TYR A 1 150 ? 147.369 146.410 153.029 1.00 51.57  ? 71  TYR A CB  1 
ATOM 126  C CG  . TYR A 1 150 ? 147.307 147.183 151.731 1.00 50.61  ? 71  TYR A CG  1 
ATOM 127  C CD1 . TYR A 1 150 ? 146.842 148.490 151.700 1.00 49.14  ? 71  TYR A CD1 1 
ATOM 128  C CD2 . TYR A 1 150 ? 147.721 146.607 150.537 1.00 51.19  ? 71  TYR A CD2 1 
ATOM 129  C CE1 . TYR A 1 150 ? 146.782 149.197 150.516 1.00 48.83  ? 71  TYR A CE1 1 
ATOM 130  C CE2 . TYR A 1 150 ? 147.667 147.307 149.349 1.00 50.17  ? 71  TYR A CE2 1 
ATOM 131  C CZ  . TYR A 1 150 ? 147.197 148.601 149.344 1.00 52.63  ? 71  TYR A CZ  1 
ATOM 132  O OH  . TYR A 1 150 ? 147.142 149.301 148.161 1.00 56.77  ? 71  TYR A OH  1 
ATOM 133  N N   . GLY A 1 151 ? 145.651 143.960 152.114 1.00 44.74  ? 72  GLY A N   1 
ATOM 134  C CA  . GLY A 1 151 ? 144.943 143.180 151.114 1.00 44.83  ? 72  GLY A CA  1 
ATOM 135  C C   . GLY A 1 151 ? 143.529 142.835 151.537 1.00 43.01  ? 72  GLY A C   1 
ATOM 136  O O   . GLY A 1 151 ? 142.623 142.769 150.702 1.00 44.17  ? 72  GLY A O   1 
ATOM 137  N N   . TYR A 1 152 ? 143.324 142.598 152.836 1.00 43.28  ? 73  TYR A N   1 
ATOM 138  C CA  . TYR A 1 152 ? 141.996 142.253 153.336 1.00 40.07  ? 73  TYR A CA  1 
ATOM 139  C C   . TYR A 1 152 ? 141.014 143.404 153.155 1.00 33.73  ? 73  TYR A C   1 
ATOM 140  O O   . TYR A 1 152 ? 139.883 143.194 152.705 1.00 30.05  ? 73  TYR A O   1 
ATOM 141  C CB  . TYR A 1 152 ? 142.093 141.816 154.804 1.00 39.93  ? 73  TYR A CB  1 
ATOM 142  C CG  . TYR A 1 152 ? 140.793 141.336 155.424 1.00 32.66  ? 73  TYR A CG  1 
ATOM 143  C CD1 . TYR A 1 152 ? 139.874 142.233 155.957 1.00 32.81  ? 73  TYR A CD1 1 
ATOM 144  C CD2 . TYR A 1 152 ? 140.467 139.987 155.433 1.00 35.04  ? 73  TYR A CD2 1 
ATOM 145  C CE1 . TYR A 1 152 ? 138.695 141.802 156.507 1.00 31.89  ? 73  TYR A CE1 1 
ATOM 146  C CE2 . TYR A 1 152 ? 139.278 139.546 155.977 1.00 36.15  ? 73  TYR A CE2 1 
ATOM 147  C CZ  . TYR A 1 152 ? 138.396 140.461 156.510 1.00 34.20  ? 73  TYR A CZ  1 
ATOM 148  O OH  . TYR A 1 152 ? 137.208 140.038 157.051 1.00 35.29  ? 73  TYR A OH  1 
ATOM 149  N N   . ASN A 1 153 ? 141.426 144.624 153.484 1.00 36.10  ? 74  ASN A N   1 
ATOM 150  C CA  . ASN A 1 153 ? 140.510 145.753 153.396 1.00 36.26  ? 74  ASN A CA  1 
ATOM 151  C C   . ASN A 1 153 ? 140.353 146.289 151.982 1.00 38.44  ? 74  ASN A C   1 
ATOM 152  O O   . ASN A 1 153 ? 139.541 147.194 151.769 1.00 39.01  ? 74  ASN A O   1 
ATOM 153  C CB  . ASN A 1 153 ? 140.960 146.869 154.336 1.00 37.16  ? 74  ASN A CB  1 
ATOM 154  C CG  . ASN A 1 153 ? 140.293 146.780 155.690 1.00 37.63  ? 74  ASN A CG  1 
ATOM 155  O OD1 . ASN A 1 153 ? 139.074 146.644 155.785 1.00 39.18  ? 74  ASN A OD1 1 
ATOM 156  N ND2 . ASN A 1 153 ? 141.088 146.831 156.743 1.00 38.67  ? 74  ASN A ND2 1 
ATOM 157  N N   . LEU A 1 154 ? 141.109 145.765 151.018 1.00 38.51  ? 75  LEU A N   1 
ATOM 158  C CA  . LEU A 1 154 ? 140.847 146.100 149.624 1.00 40.38  ? 75  LEU A CA  1 
ATOM 159  C C   . LEU A 1 154 ? 139.601 145.386 149.114 1.00 42.60  ? 75  LEU A C   1 
ATOM 160  O O   . LEU A 1 154 ? 138.840 145.945 148.319 1.00 40.69  ? 75  LEU A O   1 
ATOM 161  C CB  . LEU A 1 154 ? 142.055 145.745 148.758 1.00 39.78  ? 75  LEU A CB  1 
ATOM 162  C CG  . LEU A 1 154 ? 143.261 146.683 148.793 1.00 41.80  ? 75  LEU A CG  1 
ATOM 163  C CD1 . LEU A 1 154 ? 144.422 146.060 148.043 1.00 47.16  ? 75  LEU A CD1 1 
ATOM 164  C CD2 . LEU A 1 154 ? 142.919 148.041 148.216 1.00 40.13  ? 75  LEU A CD2 1 
ATOM 165  N N   . SER A 1 155 ? 139.371 144.154 149.566 1.00 38.82  ? 76  SER A N   1 
ATOM 166  C CA  . SER A 1 155 ? 138.330 143.310 149.003 1.00 32.07  ? 76  SER A CA  1 
ATOM 167  C C   . SER A 1 155 ? 137.166 143.038 149.944 1.00 35.11  ? 76  SER A C   1 
ATOM 168  O O   . SER A 1 155 ? 136.146 142.509 149.493 1.00 37.97  ? 76  SER A O   1 
ATOM 169  C CB  . SER A 1 155 ? 138.928 141.972 148.550 1.00 34.96  ? 76  SER A CB  1 
ATOM 170  O OG  . SER A 1 155 ? 138.894 141.027 149.602 1.00 42.03  ? 76  SER A OG  1 
ATOM 171  N N   . VAL A 1 156 ? 137.281 143.375 151.232 1.00 38.82  ? 77  VAL A N   1 
ATOM 172  C CA  . VAL A 1 156 ? 136.179 143.157 152.167 1.00 35.48  ? 77  VAL A CA  1 
ATOM 173  C C   . VAL A 1 156 ? 135.057 144.171 152.000 1.00 34.69  ? 77  VAL A C   1 
ATOM 174  O O   . VAL A 1 156 ? 133.992 144.019 152.608 1.00 32.32  ? 77  VAL A O   1 
ATOM 175  C CB  . VAL A 1 156 ? 136.704 143.166 153.619 1.00 31.59  ? 77  VAL A CB  1 
ATOM 176  C CG1 . VAL A 1 156 ? 136.775 144.587 154.173 1.00 27.22  ? 77  VAL A CG1 1 
ATOM 177  C CG2 . VAL A 1 156 ? 135.856 142.260 154.506 1.00 34.61  ? 77  VAL A CG2 1 
ATOM 178  N N   . VAL A 1 157 ? 135.259 145.193 151.174 1.00 35.96  ? 78  VAL A N   1 
ATOM 179  C CA  . VAL A 1 157 ? 134.257 146.235 150.998 1.00 33.16  ? 78  VAL A CA  1 
ATOM 180  C C   . VAL A 1 157 ? 133.232 145.867 149.924 1.00 34.11  ? 78  VAL A C   1 
ATOM 181  O O   . VAL A 1 157 ? 132.075 146.307 150.001 1.00 34.16  ? 78  VAL A O   1 
ATOM 182  C CB  . VAL A 1 157 ? 135.000 147.555 150.700 1.00 32.71  ? 78  VAL A CB  1 
ATOM 183  C CG1 . VAL A 1 157 ? 136.030 147.356 149.596 1.00 34.84  ? 78  VAL A CG1 1 
ATOM 184  C CG2 . VAL A 1 157 ? 134.064 148.703 150.398 1.00 30.40  ? 78  VAL A CG2 1 
ATOM 185  N N   . ASN A 1 158 ? 133.601 145.010 148.968 1.00 34.78  ? 79  ASN A N   1 
ATOM 186  C CA  . ASN A 1 158 ? 132.730 144.735 147.827 1.00 34.81  ? 79  ASN A CA  1 
ATOM 187  C C   . ASN A 1 158 ? 131.523 143.873 148.191 1.00 37.98  ? 79  ASN A C   1 
ATOM 188  O O   . ASN A 1 158 ? 130.438 144.053 147.628 1.00 38.51  ? 79  ASN A O   1 
ATOM 189  C CB  . ASN A 1 158 ? 133.552 144.120 146.683 1.00 34.03  ? 79  ASN A CB  1 
ATOM 190  C CG  . ASN A 1 158 ? 133.943 142.646 146.906 1.00 38.49  ? 79  ASN A CG  1 
ATOM 191  O OD1 . ASN A 1 158 ? 133.759 142.062 147.974 1.00 41.46  ? 79  ASN A OD1 1 
ATOM 192  N ND2 . ASN A 1 158 ? 134.502 142.047 145.864 1.00 38.14  ? 79  ASN A ND2 1 
ATOM 193  N N   . ALA A 1 159 ? 131.693 142.916 149.100 1.00 37.83  ? 80  ALA A N   1 
ATOM 194  C CA  . ALA A 1 159 ? 130.643 141.922 149.311 1.00 36.51  ? 80  ALA A CA  1 
ATOM 195  C C   . ALA A 1 159 ? 129.486 142.443 150.170 1.00 34.52  ? 80  ALA A C   1 
ATOM 196  O O   . ALA A 1 159 ? 128.328 142.184 149.818 1.00 32.98  ? 80  ALA A O   1 
ATOM 197  C CB  . ALA A 1 159 ? 131.234 140.629 149.888 1.00 35.34  ? 80  ALA A CB  1 
ATOM 198  N N   . PRO A 1 160 ? 129.715 143.206 151.330 1.00 36.88  ? 81  PRO A N   1 
ATOM 199  C CA  . PRO A 1 160 ? 128.584 143.841 152.018 1.00 37.40  ? 81  PRO A CA  1 
ATOM 200  C C   . PRO A 1 160 ? 128.189 145.195 151.433 1.00 36.57  ? 81  PRO A C   1 
ATOM 201  O O   . PRO A 1 160 ? 127.892 146.143 152.159 1.00 36.94  ? 81  PRO A O   1 
ATOM 202  C CB  . PRO A 1 160 ? 129.102 143.988 153.451 1.00 36.31  ? 81  PRO A CB  1 
ATOM 203  C CG  . PRO A 1 160 ? 130.531 144.221 153.263 1.00 32.73  ? 81  PRO A CG  1 
ATOM 204  C CD  . PRO A 1 160 ? 130.908 143.243 152.201 1.00 36.17  ? 81  PRO A CD  1 
ATOM 205  N N   . THR A 1 161 ? 128.174 145.285 150.109 1.00 32.35  ? 82  THR A N   1 
ATOM 206  C CA  . THR A 1 161 ? 127.825 146.544 149.460 1.00 28.63  ? 82  THR A CA  1 
ATOM 207  C C   . THR A 1 161 ? 126.314 146.812 149.477 1.00 27.57  ? 82  THR A C   1 
ATOM 208  O O   . THR A 1 161 ? 125.930 147.919 149.873 1.00 30.01  ? 82  THR A O   1 
ATOM 209  C CB  . THR A 1 161 ? 128.397 146.588 148.034 1.00 38.07  ? 82  THR A CB  1 
ATOM 210  O OG1 . THR A 1 161 ? 129.776 146.972 148.086 1.00 37.13  ? 82  THR A OG1 1 
ATOM 211  C CG2 . THR A 1 161 ? 127.644 147.583 147.158 1.00 41.24  ? 82  THR A CG2 1 
ATOM 212  N N   . PRO A 1 162 ? 125.412 145.881 149.098 1.00 30.79  ? 83  PRO A N   1 
ATOM 213  C CA  . PRO A 1 162 ? 123.977 146.222 149.175 1.00 31.90  ? 83  PRO A CA  1 
ATOM 214  C C   . PRO A 1 162 ? 123.448 146.383 150.591 1.00 35.66  ? 83  PRO A C   1 
ATOM 215  O O   . PRO A 1 162 ? 122.370 146.965 150.763 1.00 37.87  ? 83  PRO A O   1 
ATOM 216  C CB  . PRO A 1 162 ? 123.289 145.050 148.464 1.00 34.71  ? 83  PRO A CB  1 
ATOM 217  C CG  . PRO A 1 162 ? 124.221 143.936 148.592 1.00 35.88  ? 83  PRO A CG  1 
ATOM 218  C CD  . PRO A 1 162 ? 125.579 144.534 148.505 1.00 36.31  ? 83  PRO A CD  1 
ATOM 219  N N   . TYR A 1 163 ? 124.157 145.885 151.604 1.00 35.19  ? 84  TYR A N   1 
ATOM 220  C CA  . TYR A 1 163 ? 123.679 146.016 152.976 1.00 32.82  ? 84  TYR A CA  1 
ATOM 221  C C   . TYR A 1 163 ? 123.986 147.393 153.551 1.00 31.40  ? 84  TYR A C   1 
ATOM 222  O O   . TYR A 1 163 ? 123.150 147.974 154.251 1.00 35.83  ? 84  TYR A O   1 
ATOM 223  C CB  . TYR A 1 163 ? 124.292 144.926 153.853 1.00 32.66  ? 84  TYR A CB  1 
ATOM 224  C CG  . TYR A 1 163 ? 124.199 143.545 153.253 1.00 34.26  ? 84  TYR A CG  1 
ATOM 225  C CD1 . TYR A 1 163 ? 122.981 143.032 152.830 1.00 36.98  ? 84  TYR A CD1 1 
ATOM 226  C CD2 . TYR A 1 163 ? 125.328 142.753 153.113 1.00 35.90  ? 84  TYR A CD2 1 
ATOM 227  C CE1 . TYR A 1 163 ? 122.892 141.771 152.279 1.00 41.39  ? 84  TYR A CE1 1 
ATOM 228  C CE2 . TYR A 1 163 ? 125.250 141.491 152.564 1.00 44.04  ? 84  TYR A CE2 1 
ATOM 229  C CZ  . TYR A 1 163 ? 124.030 141.004 152.149 1.00 47.40  ? 84  TYR A CZ  1 
ATOM 230  O OH  . TYR A 1 163 ? 123.948 139.745 151.601 1.00 54.77  ? 84  TYR A OH  1 
ATOM 231  N N   . ILE A 1 164 ? 125.181 147.922 153.277 1.00 27.91  ? 85  ILE A N   1 
ATOM 232  C CA  . ILE A 1 164 ? 125.580 149.204 153.851 1.00 27.58  ? 85  ILE A CA  1 
ATOM 233  C C   . ILE A 1 164 ? 124.778 150.348 153.242 1.00 30.65  ? 85  ILE A C   1 
ATOM 234  O O   . ILE A 1 164 ? 124.302 151.236 153.959 1.00 34.81  ? 85  ILE A O   1 
ATOM 235  C CB  . ILE A 1 164 ? 127.095 149.413 153.688 1.00 24.09  ? 85  ILE A CB  1 
ATOM 236  C CG1 . ILE A 1 164 ? 127.862 148.418 154.555 1.00 24.17  ? 85  ILE A CG1 1 
ATOM 237  C CG2 . ILE A 1 164 ? 127.483 150.817 154.072 1.00 26.94  ? 85  ILE A CG2 1 
ATOM 238  C CD1 . ILE A 1 164 ? 129.321 148.300 154.204 1.00 25.94  ? 85  ILE A CD1 1 
ATOM 239  N N   . LYS A 1 165 ? 124.602 150.348 151.917 1.00 30.54  ? 86  LYS A N   1 
ATOM 240  C CA  . LYS A 1 165 ? 123.799 151.391 151.284 1.00 33.50  ? 86  LYS A CA  1 
ATOM 241  C C   . LYS A 1 165 ? 122.324 151.297 151.656 1.00 40.30  ? 86  LYS A C   1 
ATOM 242  O O   . LYS A 1 165 ? 121.594 152.280 151.490 1.00 47.63  ? 86  LYS A O   1 
ATOM 243  C CB  . LYS A 1 165 ? 123.968 151.351 149.765 1.00 31.27  ? 86  LYS A CB  1 
ATOM 244  C CG  . LYS A 1 165 ? 125.377 151.024 149.316 1.00 27.77  ? 86  LYS A CG  1 
ATOM 245  C CD  . LYS A 1 165 ? 125.747 151.751 148.037 1.00 29.36  ? 86  LYS A CD  1 
ATOM 246  C CE  . LYS A 1 165 ? 125.157 151.059 146.822 1.00 31.97  ? 86  LYS A CE  1 
ATOM 247  N NZ  . LYS A 1 165 ? 125.025 151.986 145.666 1.00 34.29  ? 86  LYS A NZ  1 
ATOM 248  N N   . ALA A 1 166 ? 121.866 150.142 152.142 1.00 37.26  ? 87  ALA A N   1 
ATOM 249  C CA  . ALA A 1 166 ? 120.570 150.085 152.807 1.00 39.99  ? 87  ALA A CA  1 
ATOM 250  C C   . ALA A 1 166 ? 120.656 150.652 154.219 1.00 44.54  ? 87  ALA A C   1 
ATOM 251  O O   . ALA A 1 166 ? 119.720 151.308 154.688 1.00 47.92  ? 87  ALA A O   1 
ATOM 252  C CB  . ALA A 1 166 ? 120.055 148.646 152.837 1.00 37.98  ? 87  ALA A CB  1 
ATOM 253  N N   . PHE A 1 167 ? 121.773 150.401 154.907 1.00 40.88  ? 88  PHE A N   1 
ATOM 254  C CA  . PHE A 1 167 ? 121.989 150.962 156.237 1.00 41.70  ? 88  PHE A CA  1 
ATOM 255  C C   . PHE A 1 167 ? 122.281 152.456 156.149 1.00 41.89  ? 88  PHE A C   1 
ATOM 256  O O   . PHE A 1 167 ? 121.903 153.214 157.050 1.00 45.55  ? 88  PHE A O   1 
ATOM 257  C CB  . PHE A 1 167 ? 123.122 150.179 156.922 1.00 40.42  ? 88  PHE A CB  1 
ATOM 258  C CG  . PHE A 1 167 ? 123.970 150.977 157.889 1.00 40.97  ? 88  PHE A CG  1 
ATOM 259  C CD1 . PHE A 1 167 ? 123.438 151.494 159.064 1.00 45.52  ? 88  PHE A CD1 1 
ATOM 260  C CD2 . PHE A 1 167 ? 125.312 151.193 157.621 1.00 36.14  ? 88  PHE A CD2 1 
ATOM 261  C CE1 . PHE A 1 167 ? 124.226 152.215 159.938 1.00 49.81  ? 88  PHE A CE1 1 
ATOM 262  C CE2 . PHE A 1 167 ? 126.104 151.912 158.492 1.00 35.77  ? 88  PHE A CE2 1 
ATOM 263  C CZ  . PHE A 1 167 ? 125.560 152.424 159.651 1.00 45.46  ? 88  PHE A CZ  1 
ATOM 264  N N   . TYR A 1 168 ? 122.929 152.897 155.065 1.00 36.94  ? 89  TYR A N   1 
ATOM 265  C CA  . TYR A 1 168 ? 123.155 154.325 154.857 1.00 34.84  ? 89  TYR A CA  1 
ATOM 266  C C   . TYR A 1 168 ? 121.839 155.076 154.718 1.00 40.43  ? 89  TYR A C   1 
ATOM 267  O O   . TYR A 1 168 ? 121.678 156.167 155.274 1.00 50.03  ? 89  TYR A O   1 
ATOM 268  C CB  . TYR A 1 168 ? 124.016 154.554 153.615 1.00 31.37  ? 89  TYR A CB  1 
ATOM 269  C CG  . TYR A 1 168 ? 125.506 154.503 153.857 1.00 26.57  ? 89  TYR A CG  1 
ATOM 270  C CD1 . TYR A 1 168 ? 126.018 154.265 155.123 1.00 30.93  ? 89  TYR A CD1 1 
ATOM 271  C CD2 . TYR A 1 168 ? 126.401 154.715 152.818 1.00 27.98  ? 89  TYR A CD2 1 
ATOM 272  C CE1 . TYR A 1 168 ? 127.379 154.223 155.344 1.00 30.65  ? 89  TYR A CE1 1 
ATOM 273  C CE2 . TYR A 1 168 ? 127.762 154.676 153.031 1.00 27.45  ? 89  TYR A CE2 1 
ATOM 274  C CZ  . TYR A 1 168 ? 128.244 154.431 154.295 1.00 27.06  ? 89  TYR A CZ  1 
ATOM 275  O OH  . TYR A 1 168 ? 129.599 154.393 154.516 1.00 27.76  ? 89  TYR A OH  1 
ATOM 276  N N   . ASN A 1 169 ? 120.887 154.504 153.978 1.00 43.41  ? 90  ASN A N   1 
ATOM 277  C CA  . ASN A 1 169 ? 119.595 155.156 153.802 1.00 51.54  ? 90  ASN A CA  1 
ATOM 278  C C   . ASN A 1 169 ? 118.770 155.117 155.083 1.00 58.39  ? 90  ASN A C   1 
ATOM 279  O O   . ASN A 1 169 ? 118.053 156.075 155.390 1.00 65.57  ? 90  ASN A O   1 
ATOM 280  C CB  . ASN A 1 169 ? 118.830 154.502 152.653 1.00 53.39  ? 90  ASN A CB  1 
ATOM 281  C CG  . ASN A 1 169 ? 117.580 155.270 152.277 1.00 62.65  ? 90  ASN A CG  1 
ATOM 282  O OD1 . ASN A 1 169 ? 117.641 156.453 151.944 1.00 67.75  ? 90  ASN A OD1 1 
ATOM 283  N ND2 . ASN A 1 169 ? 116.436 154.599 152.330 1.00 67.09  ? 90  ASN A ND2 1 
ATOM 284  N N   . GLU A 1 170 ? 118.845 154.012 155.832 1.00 56.67  ? 91  GLU A N   1 
ATOM 285  C CA  . GLU A 1 170 ? 118.086 153.902 157.075 1.00 56.10  ? 91  GLU A CA  1 
ATOM 286  C C   . GLU A 1 170 ? 118.584 154.886 158.126 1.00 59.81  ? 91  GLU A C   1 
ATOM 287  O O   . GLU A 1 170 ? 117.781 155.527 158.814 1.00 64.15  ? 91  GLU A O   1 
ATOM 288  C CB  . GLU A 1 170 ? 118.157 152.474 157.616 1.00 55.77  ? 91  GLU A CB  1 
ATOM 289  C CG  . GLU A 1 170 ? 116.977 151.597 157.235 1.00 57.78  ? 91  GLU A CG  1 
ATOM 290  C CD  . GLU A 1 170 ? 117.355 150.135 157.115 1.00 57.61  ? 91  GLU A CD  1 
ATOM 291  O OE1 . GLU A 1 170 ? 118.072 149.631 158.004 1.00 56.49  ? 91  GLU A OE1 1 
ATOM 292  O OE2 . GLU A 1 170 ? 116.936 149.489 156.132 1.00 59.73  ? 91  GLU A OE2 1 
ATOM 293  N N   . SER A 1 171 ? 119.906 155.010 158.271 1.00 58.46  ? 92  SER A N   1 
ATOM 294  C CA  . SER A 1 171 ? 120.463 155.936 159.252 1.00 61.14  ? 92  SER A CA  1 
ATOM 295  C C   . SER A 1 171 ? 120.185 157.382 158.867 1.00 64.92  ? 92  SER A C   1 
ATOM 296  O O   . SER A 1 171 ? 119.957 158.230 159.736 1.00 72.11  ? 92  SER A O   1 
ATOM 297  C CB  . SER A 1 171 ? 121.964 155.700 159.407 1.00 55.63  ? 92  SER A CB  1 
ATOM 298  O OG  . SER A 1 171 ? 122.219 154.691 160.367 1.00 57.56  ? 92  SER A OG  1 
ATOM 299  N N   . TRP A 1 172 ? 120.211 157.683 157.569 1.00 58.95  ? 93  TRP A N   1 
ATOM 300  C CA  . TRP A 1 172 ? 119.849 159.013 157.100 1.00 65.62  ? 93  TRP A CA  1 
ATOM 301  C C   . TRP A 1 172 ? 118.356 159.273 157.262 1.00 71.90  ? 93  TRP A C   1 
ATOM 302  O O   . TRP A 1 172 ? 117.954 160.427 157.440 1.00 78.52  ? 93  TRP A O   1 
ATOM 303  C CB  . TRP A 1 172 ? 120.305 159.155 155.642 1.00 65.89  ? 93  TRP A CB  1 
ATOM 304  C CG  . TRP A 1 172 ? 120.058 160.471 154.940 1.00 74.84  ? 93  TRP A CG  1 
ATOM 305  C CD1 . TRP A 1 172 ? 118.857 161.015 154.585 1.00 79.44  ? 93  TRP A CD1 1 
ATOM 306  C CD2 . TRP A 1 172 ? 121.060 161.383 154.471 1.00 77.81  ? 93  TRP A CD2 1 
ATOM 307  N NE1 . TRP A 1 172 ? 119.049 162.214 153.945 1.00 81.89  ? 93  TRP A NE1 1 
ATOM 308  C CE2 . TRP A 1 172 ? 120.393 162.462 153.861 1.00 81.02  ? 93  TRP A CE2 1 
ATOM 309  C CE3 . TRP A 1 172 ? 122.458 161.395 154.517 1.00 77.85  ? 93  TRP A CE3 1 
ATOM 310  C CZ2 . TRP A 1 172 ? 121.074 163.542 153.302 1.00 83.81  ? 93  TRP A CZ2 1 
ATOM 311  C CZ3 . TRP A 1 172 ? 123.132 162.467 153.962 1.00 82.60  ? 93  TRP A CZ3 1 
ATOM 312  C CH2 . TRP A 1 172 ? 122.440 163.526 153.363 1.00 84.65  ? 93  TRP A CH2 1 
ATOM 313  N N   . GLU A 1 173 ? 117.531 158.223 157.241 1.00 71.47  ? 94  GLU A N   1 
ATOM 314  C CA  . GLU A 1 173 ? 116.094 158.373 157.437 1.00 74.59  ? 94  GLU A CA  1 
ATOM 315  C C   . GLU A 1 173 ? 115.708 158.447 158.909 1.00 76.02  ? 94  GLU A C   1 
ATOM 316  O O   . GLU A 1 173 ? 114.721 159.110 159.248 1.00 80.10  ? 94  GLU A O   1 
ATOM 317  C CB  . GLU A 1 173 ? 115.342 157.218 156.770 1.00 76.91  ? 94  GLU A CB  1 
ATOM 318  C CG  . GLU A 1 173 ? 113.908 157.536 156.352 1.00 83.32  ? 94  GLU A CG  1 
ATOM 319  C CD  . GLU A 1 173 ? 113.823 158.583 155.252 1.00 87.98  ? 94  GLU A CD  1 
ATOM 320  O OE1 . GLU A 1 173 ? 113.856 159.793 155.562 1.00 87.39  ? 94  GLU A OE1 1 
ATOM 321  O OE2 . GLU A 1 173 ? 113.727 158.192 154.070 1.00 86.32  ? 94  GLU A OE2 1 
ATOM 322  N N   . ARG A 1 174 ? 116.455 157.785 159.790 1.00 75.25  ? 95  ARG A N   1 
ATOM 323  C CA  . ARG A 1 174 ? 116.297 157.938 161.241 1.00 75.56  ? 95  ARG A CA  1 
ATOM 324  C C   . ARG A 1 174 ? 117.130 159.113 161.783 1.00 74.74  ? 95  ARG A C   1 
ATOM 325  O O   . ARG A 1 174 ? 117.749 159.116 162.849 1.00 71.44  ? 95  ARG A O   1 
ATOM 326  C CB  . ARG A 1 174 ? 116.594 156.589 161.905 1.00 73.18  ? 95  ARG A CB  1 
ATOM 327  C CG  . ARG A 1 174 ? 118.043 156.179 162.206 1.00 70.45  ? 95  ARG A CG  1 
ATOM 328  C CD  . ARG A 1 174 ? 118.128 154.736 162.678 1.00 69.27  ? 95  ARG A CD  1 
ATOM 329  N NE  . ARG A 1 174 ? 117.113 153.887 162.063 1.00 69.17  ? 95  ARG A NE  1 
ATOM 330  C CZ  . ARG A 1 174 ? 116.173 153.232 162.730 1.00 72.97  ? 95  ARG A CZ  1 
ATOM 331  N NH1 . ARG A 1 174 ? 116.083 153.302 164.048 1.00 75.92  ? 95  ARG A NH1 1 
ATOM 332  N NH2 . ARG A 1 174 ? 115.296 152.491 162.057 1.00 73.46  ? 95  ARG A NH2 1 
ATOM 333  N N   . ARG A 1 175 ? 117.001 160.210 161.047 1.00 75.34  ? 96  ARG A N   1 
ATOM 334  C CA  . ARG A 1 175 ? 117.742 161.451 161.197 1.00 77.94  ? 96  ARG A CA  1 
ATOM 335  C C   . ARG A 1 175 ? 116.884 162.509 160.507 1.00 79.97  ? 96  ARG A C   1 
ATOM 336  O O   . ARG A 1 175 ? 115.658 162.360 160.448 1.00 79.31  ? 96  ARG A O   1 
ATOM 337  C CB  . ARG A 1 175 ? 119.170 161.297 160.645 1.00 76.60  ? 96  ARG A CB  1 
ATOM 338  C CG  . ARG A 1 175 ? 120.200 162.220 161.292 1.00 74.47  ? 96  ARG A CG  1 
ATOM 339  C CD  . ARG A 1 175 ? 121.587 162.013 160.713 1.00 69.14  ? 96  ARG A CD  1 
ATOM 340  N NE  . ARG A 1 175 ? 122.226 160.826 161.267 1.00 66.25  ? 96  ARG A NE  1 
ATOM 341  C CZ  . ARG A 1 175 ? 123.529 160.586 161.221 1.00 61.95  ? 96  ARG A CZ  1 
ATOM 342  N NH1 . ARG A 1 175 ? 124.364 161.430 160.642 1.00 63.30  ? 96  ARG A NH1 1 
ATOM 343  N NH2 . ARG A 1 175 ? 124.004 159.472 161.768 1.00 58.48  ? 96  ARG A NH2 1 
ATOM 344  N N   . HIS A 1 176 ? 117.502 163.619 160.085 1.00 81.62  ? 97  HIS A N   1 
ATOM 345  C CA  . HIS A 1 176 ? 116.854 164.574 159.186 1.00 81.27  ? 97  HIS A CA  1 
ATOM 346  C C   . HIS A 1 176 ? 116.233 163.821 158.012 1.00 80.48  ? 97  HIS A C   1 
ATOM 347  O O   . HIS A 1 176 ? 116.939 163.212 157.201 1.00 78.00  ? 97  HIS A O   1 
ATOM 348  C CB  . HIS A 1 176 ? 117.828 165.656 158.671 1.00 83.44  ? 97  HIS A CB  1 
ATOM 349  C CG  . HIS A 1 176 ? 119.102 165.143 158.049 1.00 86.19  ? 97  HIS A CG  1 
ATOM 350  N ND1 . HIS A 1 176 ? 119.799 164.047 158.511 1.00 80.93  ? 97  HIS A ND1 1 
ATOM 351  C CD2 . HIS A 1 176 ? 119.800 165.598 156.980 1.00 89.23  ? 97  HIS A CD2 1 
ATOM 352  C CE1 . HIS A 1 176 ? 120.867 163.848 157.760 1.00 80.53  ? 97  HIS A CE1 1 
ATOM 353  N NE2 . HIS A 1 176 ? 120.891 164.777 156.823 1.00 83.14  ? 97  HIS A NE2 1 
ATOM 354  N N   . GLY A 1 177 ? 114.904 163.844 157.931 1.00 84.64  ? 98  GLY A N   1 
ATOM 355  C CA  . GLY A 1 177 ? 114.193 162.831 157.176 1.00 86.07  ? 98  GLY A CA  1 
ATOM 356  C C   . GLY A 1 177 ? 113.780 163.146 155.755 1.00 96.12  ? 98  GLY A C   1 
ATOM 357  O O   . GLY A 1 177 ? 112.732 163.756 155.523 1.00 99.50  ? 98  GLY A O   1 
ATOM 358  N N   . ARG A 1 178 ? 114.597 162.716 154.799 1.00 97.44  ? 99  ARG A N   1 
ATOM 359  C CA  . ARG A 1 178 ? 114.233 162.542 153.402 1.00 93.96  ? 99  ARG A CA  1 
ATOM 360  C C   . ARG A 1 178 ? 114.940 161.295 152.897 1.00 90.34  ? 99  ARG A C   1 
ATOM 361  O O   . ARG A 1 178 ? 115.997 160.928 153.424 1.00 86.54  ? 99  ARG A O   1 
ATOM 362  C CB  . ARG A 1 178 ? 114.619 163.745 152.522 1.00 96.53  ? 99  ARG A CB  1 
ATOM 363  C CG  . ARG A 1 178 ? 113.836 165.021 152.792 1.00 106.12 ? 99  ARG A CG  1 
ATOM 364  C CD  . ARG A 1 178 ? 114.387 166.198 152.004 1.00 119.34 ? 99  ARG A CD  1 
ATOM 365  N NE  . ARG A 1 178 ? 115.747 166.546 152.395 1.00 126.18 ? 99  ARG A NE  1 
ATOM 366  C CZ  . ARG A 1 178 ? 116.447 167.535 151.858 1.00 130.85 ? 99  ARG A CZ  1 
ATOM 367  N NH1 . ARG A 1 178 ? 115.947 168.294 150.896 1.00 134.96 ? 99  ARG A NH1 1 
ATOM 368  N NH2 . ARG A 1 178 ? 117.680 167.771 152.298 1.00 127.15 ? 99  ARG A NH2 1 
ATOM 369  N N   . PRO A 1 179 ? 114.368 160.603 151.913 1.00 93.93  ? 100 PRO A N   1 
ATOM 370  C CA  . PRO A 1 179 ? 115.110 159.521 151.259 1.00 94.19  ? 100 PRO A CA  1 
ATOM 371  C C   . PRO A 1 179 ? 116.334 160.064 150.539 1.00 92.41  ? 100 PRO A C   1 
ATOM 372  O O   . PRO A 1 179 ? 116.331 161.182 150.021 1.00 92.94  ? 100 PRO A O   1 
ATOM 373  C CB  . PRO A 1 179 ? 114.092 158.934 150.275 1.00 93.41  ? 100 PRO A CB  1 
ATOM 374  C CG  . PRO A 1 179 ? 112.766 159.288 150.859 1.00 96.72  ? 100 PRO A CG  1 
ATOM 375  C CD  . PRO A 1 179 ? 112.959 160.638 151.485 1.00 96.77  ? 100 PRO A CD  1 
ATOM 376  N N   . ILE A 1 180 ? 117.398 159.261 150.525 1.00 88.93  ? 101 ILE A N   1 
ATOM 377  C CA  . ILE A 1 180 ? 118.639 159.679 149.886 1.00 83.17  ? 101 ILE A CA  1 
ATOM 378  C C   . ILE A 1 180 ? 118.459 159.659 148.375 1.00 84.06  ? 101 ILE A C   1 
ATOM 379  O O   . ILE A 1 180 ? 118.047 158.644 147.797 1.00 89.19  ? 101 ILE A O   1 
ATOM 380  C CB  . ILE A 1 180 ? 119.802 158.772 150.314 1.00 77.08  ? 101 ILE A CB  1 
ATOM 381  C CG1 . ILE A 1 180 ? 120.072 158.910 151.816 1.00 74.40  ? 101 ILE A CG1 1 
ATOM 382  C CG2 . ILE A 1 180 ? 121.047 159.104 149.508 1.00 73.21  ? 101 ILE A CG2 1 
ATOM 383  C CD1 . ILE A 1 180 ? 121.504 158.585 152.239 1.00 70.60  ? 101 ILE A CD1 1 
ATOM 384  N N   . ASP A 1 181 ? 118.754 160.786 147.731 1.00 81.03  ? 102 ASP A N   1 
ATOM 385  C CA  . ASP A 1 181 ? 118.768 160.834 146.279 1.00 84.49  ? 102 ASP A CA  1 
ATOM 386  C C   . ASP A 1 181 ? 119.879 159.933 145.734 1.00 81.40  ? 102 ASP A C   1 
ATOM 387  O O   . ASP A 1 181 ? 120.940 159.807 146.351 1.00 80.76  ? 102 ASP A O   1 
ATOM 388  C CB  . ASP A 1 181 ? 118.951 162.274 145.800 1.00 87.38  ? 102 ASP A CB  1 
ATOM 389  C CG  . ASP A 1 181 ? 120.030 163.010 146.564 1.00 86.37  ? 102 ASP A CG  1 
ATOM 390  O OD1 . ASP A 1 181 ? 120.606 162.414 147.497 1.00 85.35  ? 102 ASP A OD1 1 
ATOM 391  O OD2 . ASP A 1 181 ? 120.303 164.183 146.233 1.00 85.72  ? 102 ASP A OD2 1 
ATOM 392  N N   . PRO A 1 182 ? 119.650 159.281 144.588 1.00 82.12  ? 103 PRO A N   1 
ATOM 393  C CA  . PRO A 1 182 ? 120.587 158.240 144.122 1.00 80.19  ? 103 PRO A CA  1 
ATOM 394  C C   . PRO A 1 182 ? 121.993 158.732 143.810 1.00 75.17  ? 103 PRO A C   1 
ATOM 395  O O   . PRO A 1 182 ? 122.917 157.911 143.773 1.00 71.58  ? 103 PRO A O   1 
ATOM 396  C CB  . PRO A 1 182 ? 119.902 157.693 142.862 1.00 84.26  ? 103 PRO A CB  1 
ATOM 397  C CG  . PRO A 1 182 ? 118.458 158.007 143.051 1.00 85.00  ? 103 PRO A CG  1 
ATOM 398  C CD  . PRO A 1 182 ? 118.429 159.324 143.765 1.00 84.97  ? 103 PRO A CD  1 
ATOM 399  N N   . ASP A 1 183 ? 122.186 160.030 143.571 1.00 78.30  ? 104 ASP A N   1 
ATOM 400  C CA  . ASP A 1 183 ? 123.528 160.537 143.300 1.00 80.53  ? 104 ASP A CA  1 
ATOM 401  C C   . ASP A 1 183 ? 124.407 160.479 144.545 1.00 71.45  ? 104 ASP A C   1 
ATOM 402  O O   . ASP A 1 183 ? 125.544 159.996 144.491 1.00 68.37  ? 104 ASP A O   1 
ATOM 403  C CB  . ASP A 1 183 ? 123.456 161.965 142.763 1.00 88.10  ? 104 ASP A CB  1 
ATOM 404  C CG  . ASP A 1 183 ? 124.776 162.436 142.186 1.00 91.63  ? 104 ASP A CG  1 
ATOM 405  O OD1 . ASP A 1 183 ? 125.246 161.831 141.201 1.00 87.77  ? 104 ASP A OD1 1 
ATOM 406  O OD2 . ASP A 1 183 ? 125.347 163.409 142.723 1.00 93.32  ? 104 ASP A OD2 1 
ATOM 407  N N   . THR A 1 184 ? 123.898 160.964 145.677 1.00 72.27  ? 105 THR A N   1 
ATOM 408  C CA  . THR A 1 184 ? 124.713 161.065 146.881 1.00 68.89  ? 105 THR A CA  1 
ATOM 409  C C   . THR A 1 184 ? 124.819 159.762 147.661 1.00 62.92  ? 105 THR A C   1 
ATOM 410  O O   . THR A 1 184 ? 125.669 159.671 148.553 1.00 61.77  ? 105 THR A O   1 
ATOM 411  C CB  . THR A 1 184 ? 124.179 162.170 147.796 1.00 72.40  ? 105 THR A CB  1 
ATOM 412  O OG1 . THR A 1 184 ? 123.133 161.648 148.625 1.00 72.20  ? 105 THR A OG1 1 
ATOM 413  C CG2 . THR A 1 184 ? 123.666 163.346 146.977 1.00 76.30  ? 105 THR A CG2 1 
ATOM 414  N N   . LEU A 1 185 ? 123.981 158.763 147.370 1.00 62.35  ? 106 LEU A N   1 
ATOM 415  C CA  . LEU A 1 185 ? 124.177 157.452 147.983 1.00 58.37  ? 106 LEU A CA  1 
ATOM 416  C C   . LEU A 1 185 ? 125.459 156.805 147.474 1.00 54.92  ? 106 LEU A C   1 
ATOM 417  O O   . LEU A 1 185 ? 126.243 156.262 148.261 1.00 52.11  ? 106 LEU A O   1 
ATOM 418  C CB  . LEU A 1 185 ? 122.974 156.548 147.707 1.00 61.01  ? 106 LEU A CB  1 
ATOM 419  C CG  . LEU A 1 185 ? 122.868 155.185 148.407 1.00 50.13  ? 106 LEU A CG  1 
ATOM 420  C CD1 . LEU A 1 185 ? 123.477 155.190 149.807 1.00 43.67  ? 106 LEU A CD1 1 
ATOM 421  C CD2 . LEU A 1 185 ? 121.418 154.730 148.461 1.00 53.62  ? 106 LEU A CD2 1 
ATOM 422  N N   . THR A 1 186 ? 125.690 156.859 146.161 1.00 52.73  ? 107 THR A N   1 
ATOM 423  C CA  . THR A 1 186 ? 126.942 156.354 145.613 1.00 48.77  ? 107 THR A CA  1 
ATOM 424  C C   . THR A 1 186 ? 128.103 157.288 145.920 1.00 46.70  ? 107 THR A C   1 
ATOM 425  O O   . THR A 1 186 ? 129.252 156.839 145.980 1.00 43.09  ? 107 THR A O   1 
ATOM 426  C CB  . THR A 1 186 ? 126.821 156.146 144.106 1.00 51.47  ? 107 THR A CB  1 
ATOM 427  O OG1 . THR A 1 186 ? 127.145 157.366 143.428 1.00 55.06  ? 107 THR A OG1 1 
ATOM 428  C CG2 . THR A 1 186 ? 125.411 155.718 143.738 1.00 55.23  ? 107 THR A CG2 1 
ATOM 429  N N   . LEU A 1 187 ? 127.829 158.583 146.102 1.00 51.39  ? 108 LEU A N   1 
ATOM 430  C CA  . LEU A 1 187 ? 128.882 159.510 146.504 1.00 47.78  ? 108 LEU A CA  1 
ATOM 431  C C   . LEU A 1 187 ? 129.352 159.211 147.922 1.00 44.32  ? 108 LEU A C   1 
ATOM 432  O O   . LEU A 1 187 ? 130.558 159.192 148.188 1.00 44.42  ? 108 LEU A O   1 
ATOM 433  C CB  . LEU A 1 187 ? 128.383 160.953 146.388 1.00 48.99  ? 108 LEU A CB  1 
ATOM 434  C CG  . LEU A 1 187 ? 129.192 162.148 146.914 1.00 48.42  ? 108 LEU A CG  1 
ATOM 435  C CD1 . LEU A 1 187 ? 130.683 162.064 146.575 1.00 45.48  ? 108 LEU A CD1 1 
ATOM 436  C CD2 . LEU A 1 187 ? 128.602 163.454 146.404 1.00 54.71  ? 108 LEU A CD2 1 
ATOM 437  N N   . LEU A 1 188 ? 128.413 158.973 148.844 1.00 45.29  ? 109 LEU A N   1 
ATOM 438  C CA  . LEU A 1 188 ? 128.784 158.584 150.201 1.00 42.17  ? 109 LEU A CA  1 
ATOM 439  C C   . LEU A 1 188 ? 129.478 157.230 150.216 1.00 38.86  ? 109 LEU A C   1 
ATOM 440  O O   . LEU A 1 188 ? 130.429 157.020 150.977 1.00 41.15  ? 109 LEU A O   1 
ATOM 441  C CB  . LEU A 1 188 ? 127.553 158.556 151.105 1.00 42.16  ? 109 LEU A CB  1 
ATOM 442  C CG  . LEU A 1 188 ? 127.254 159.822 151.907 1.00 43.52  ? 109 LEU A CG  1 
ATOM 443  C CD1 . LEU A 1 188 ? 125.799 159.847 152.345 1.00 46.66  ? 109 LEU A CD1 1 
ATOM 444  C CD2 . LEU A 1 188 ? 128.181 159.908 153.106 1.00 45.38  ? 109 LEU A CD2 1 
ATOM 445  N N   . TRP A 1 189 ? 129.005 156.294 149.391 1.00 32.45  ? 110 TRP A N   1 
ATOM 446  C CA  . TRP A 1 189 ? 129.636 154.982 149.332 1.00 31.51  ? 110 TRP A CA  1 
ATOM 447  C C   . TRP A 1 189 ? 131.034 155.054 148.730 1.00 36.14  ? 110 TRP A C   1 
ATOM 448  O O   . TRP A 1 189 ? 131.943 154.356 149.188 1.00 36.73  ? 110 TRP A O   1 
ATOM 449  C CB  . TRP A 1 189 ? 128.760 154.006 148.550 1.00 35.81  ? 110 TRP A CB  1 
ATOM 450  C CG  . TRP A 1 189 ? 129.345 152.628 148.446 1.00 30.51  ? 110 TRP A CG  1 
ATOM 451  C CD1 . TRP A 1 189 ? 129.644 151.958 147.299 1.00 29.55  ? 110 TRP A CD1 1 
ATOM 452  C CD2 . TRP A 1 189 ? 129.715 151.757 149.525 1.00 27.87  ? 110 TRP A CD2 1 
ATOM 453  N NE1 . TRP A 1 189 ? 130.169 150.726 147.591 1.00 31.75  ? 110 TRP A NE1 1 
ATOM 454  C CE2 . TRP A 1 189 ? 130.223 150.578 148.951 1.00 32.09  ? 110 TRP A CE2 1 
ATOM 455  C CE3 . TRP A 1 189 ? 129.660 151.855 150.920 1.00 26.18  ? 110 TRP A CE3 1 
ATOM 456  C CZ2 . TRP A 1 189 ? 130.673 149.512 149.718 1.00 34.64  ? 110 TRP A CZ2 1 
ATOM 457  C CZ3 . TRP A 1 189 ? 130.114 150.797 151.676 1.00 24.33  ? 110 TRP A CZ3 1 
ATOM 458  C CH2 . TRP A 1 189 ? 130.611 149.640 151.076 1.00 29.43  ? 110 TRP A CH2 1 
ATOM 459  N N   . SER A 1 190 ? 131.226 155.889 147.704 1.00 40.08  ? 111 SER A N   1 
ATOM 460  C CA  . SER A 1 190 ? 132.556 156.047 147.122 1.00 36.87  ? 111 SER A CA  1 
ATOM 461  C C   . SER A 1 190 ? 133.515 156.705 148.106 1.00 34.47  ? 111 SER A C   1 
ATOM 462  O O   . SER A 1 190 ? 134.715 156.412 148.100 1.00 31.95  ? 111 SER A O   1 
ATOM 463  C CB  . SER A 1 190 ? 132.479 156.855 145.829 1.00 38.38  ? 111 SER A CB  1 
ATOM 464  O OG  . SER A 1 190 ? 131.340 156.495 145.069 1.00 40.22  ? 111 SER A OG  1 
ATOM 465  N N   . VAL A 1 191 ? 133.006 157.608 148.948 1.00 35.47  ? 112 VAL A N   1 
ATOM 466  C CA  . VAL A 1 191 ? 133.819 158.182 150.018 1.00 30.85  ? 112 VAL A CA  1 
ATOM 467  C C   . VAL A 1 191 ? 134.232 157.103 151.012 1.00 30.71  ? 112 VAL A C   1 
ATOM 468  O O   . VAL A 1 191 ? 135.390 157.049 151.440 1.00 34.79  ? 112 VAL A O   1 
ATOM 469  C CB  . VAL A 1 191 ? 133.064 159.339 150.701 1.00 29.15  ? 112 VAL A CB  1 
ATOM 470  C CG1 . VAL A 1 191 ? 133.724 159.726 152.011 1.00 29.57  ? 112 VAL A CG1 1 
ATOM 471  C CG2 . VAL A 1 191 ? 133.025 160.545 149.783 1.00 34.75  ? 112 VAL A CG2 1 
ATOM 472  N N   . THR A 1 192 ? 133.301 156.214 151.373 1.00 27.18  ? 113 THR A N   1 
ATOM 473  C CA  . THR A 1 192 ? 133.614 155.117 152.287 1.00 27.72  ? 113 THR A CA  1 
ATOM 474  C C   . THR A 1 192 ? 134.675 154.193 151.697 1.00 31.05  ? 113 THR A C   1 
ATOM 475  O O   . THR A 1 192 ? 135.604 153.768 152.397 1.00 33.30  ? 113 THR A O   1 
ATOM 476  C CB  . THR A 1 192 ? 132.333 154.344 152.616 1.00 26.44  ? 113 THR A CB  1 
ATOM 477  O OG1 . THR A 1 192 ? 131.589 155.059 153.607 1.00 33.04  ? 113 THR A OG1 1 
ATOM 478  C CG2 . THR A 1 192 ? 132.633 152.953 153.154 1.00 26.08  ? 113 THR A CG2 1 
ATOM 479  N N   . VAL A 1 193 ? 134.574 153.908 150.398 1.00 31.66  ? 114 VAL A N   1 
ATOM 480  C CA  . VAL A 1 193 ? 135.559 153.064 149.730 1.00 29.11  ? 114 VAL A CA  1 
ATOM 481  C C   . VAL A 1 193 ? 136.913 153.762 149.643 1.00 31.76  ? 114 VAL A C   1 
ATOM 482  O O   . VAL A 1 193 ? 137.954 153.169 149.950 1.00 31.69  ? 114 VAL A O   1 
ATOM 483  C CB  . VAL A 1 193 ? 135.040 152.666 148.337 1.00 27.76  ? 114 VAL A CB  1 
ATOM 484  C CG1 . VAL A 1 193 ? 136.092 151.918 147.590 1.00 35.39  ? 114 VAL A CG1 1 
ATOM 485  C CG2 . VAL A 1 193 ? 133.799 151.812 148.455 1.00 24.89  ? 114 VAL A CG2 1 
ATOM 486  N N   . SER A 1 194 ? 136.923 155.034 149.244 1.00 31.18  ? 115 SER A N   1 
ATOM 487  C CA  . SER A 1 194 ? 138.159 155.696 148.846 1.00 29.96  ? 115 SER A CA  1 
ATOM 488  C C   . SER A 1 194 ? 138.851 156.474 149.959 1.00 33.94  ? 115 SER A C   1 
ATOM 489  O O   . SER A 1 194 ? 140.000 156.884 149.768 1.00 38.98  ? 115 SER A O   1 
ATOM 490  C CB  . SER A 1 194 ? 137.890 156.642 147.677 1.00 32.84  ? 115 SER A CB  1 
ATOM 491  O OG  . SER A 1 194 ? 137.413 157.887 148.148 1.00 32.73  ? 115 SER A OG  1 
ATOM 492  N N   . ILE A 1 195 ? 138.203 156.701 151.106 1.00 31.61  ? 116 ILE A N   1 
ATOM 493  C CA  . ILE A 1 195 ? 138.882 157.404 152.193 1.00 29.41  ? 116 ILE A CA  1 
ATOM 494  C C   . ILE A 1 195 ? 139.935 156.538 152.866 1.00 31.03  ? 116 ILE A C   1 
ATOM 495  O O   . ILE A 1 195 ? 140.776 157.060 153.606 1.00 36.05  ? 116 ILE A O   1 
ATOM 496  C CB  . ILE A 1 195 ? 137.874 157.942 153.233 1.00 28.60  ? 116 ILE A CB  1 
ATOM 497  C CG1 . ILE A 1 195 ? 138.389 159.234 153.871 1.00 30.90  ? 116 ILE A CG1 1 
ATOM 498  C CG2 . ILE A 1 195 ? 137.560 156.903 154.293 1.00 30.70  ? 116 ILE A CG2 1 
ATOM 499  C CD1 . ILE A 1 195 ? 138.442 160.405 152.916 1.00 29.65  ? 116 ILE A CD1 1 
ATOM 500  N N   . PHE A 1 196 ? 139.917 155.226 152.616 1.00 30.05  ? 117 PHE A N   1 
ATOM 501  C CA  . PHE A 1 196 ? 140.998 154.361 153.070 1.00 33.67  ? 117 PHE A CA  1 
ATOM 502  C C   . PHE A 1 196 ? 142.294 154.690 152.336 1.00 37.43  ? 117 PHE A C   1 
ATOM 503  O O   . PHE A 1 196 ? 143.384 154.494 152.885 1.00 43.96  ? 117 PHE A O   1 
ATOM 504  C CB  . PHE A 1 196 ? 140.548 152.895 152.911 1.00 37.92  ? 117 PHE A CB  1 
ATOM 505  C CG  . PHE A 1 196 ? 141.659 151.863 152.875 1.00 38.97  ? 117 PHE A CG  1 
ATOM 506  C CD1 . PHE A 1 196 ? 142.330 151.549 151.695 1.00 40.78  ? 117 PHE A CD1 1 
ATOM 507  C CD2 . PHE A 1 196 ? 142.001 151.176 154.028 1.00 39.68  ? 117 PHE A CD2 1 
ATOM 508  C CE1 . PHE A 1 196 ? 143.331 150.597 151.682 1.00 44.53  ? 117 PHE A CE1 1 
ATOM 509  C CE2 . PHE A 1 196 ? 143.001 150.223 154.017 1.00 44.08  ? 117 PHE A CE2 1 
ATOM 510  C CZ  . PHE A 1 196 ? 143.665 149.934 152.845 1.00 46.26  ? 117 PHE A CZ  1 
ATOM 511  N N   . ALA A 1 197 ? 142.195 155.194 151.103 1.00 34.85  ? 118 ALA A N   1 
ATOM 512  C CA  . ALA A 1 197 ? 143.380 155.641 150.377 1.00 32.63  ? 118 ALA A CA  1 
ATOM 513  C C   . ALA A 1 197 ? 143.958 156.917 150.979 1.00 35.27  ? 118 ALA A C   1 
ATOM 514  O O   . ALA A 1 197 ? 145.182 157.081 151.030 1.00 41.26  ? 118 ALA A O   1 
ATOM 515  C CB  . ALA A 1 197 ? 143.043 155.850 148.903 1.00 34.00  ? 118 ALA A CB  1 
ATOM 516  N N   . ILE A 1 198 ? 143.094 157.841 151.413 1.00 34.83  ? 119 ILE A N   1 
ATOM 517  C CA  . ILE A 1 198 ? 143.558 159.062 152.074 1.00 34.15  ? 119 ILE A CA  1 
ATOM 518  C C   . ILE A 1 198 ? 144.254 158.723 153.386 1.00 35.90  ? 119 ILE A C   1 
ATOM 519  O O   . ILE A 1 198 ? 145.255 159.350 153.757 1.00 43.69  ? 119 ILE A O   1 
ATOM 520  C CB  . ILE A 1 198 ? 142.383 160.039 152.281 1.00 32.80  ? 119 ILE A CB  1 
ATOM 521  C CG1 . ILE A 1 198 ? 141.834 160.525 150.940 1.00 35.79  ? 119 ILE A CG1 1 
ATOM 522  C CG2 . ILE A 1 198 ? 142.798 161.253 153.096 1.00 32.40  ? 119 ILE A CG2 1 
ATOM 523  C CD1 . ILE A 1 198 ? 142.902 160.851 149.903 1.00 32.78  ? 119 ILE A CD1 1 
ATOM 524  N N   . GLY A 1 199 ? 143.742 157.718 154.100 1.00 31.95  ? 120 GLY A N   1 
ATOM 525  C CA  . GLY A 1 199 ? 144.438 157.231 155.279 1.00 36.89  ? 120 GLY A CA  1 
ATOM 526  C C   . GLY A 1 199 ? 145.820 156.698 154.960 1.00 44.09  ? 120 GLY A C   1 
ATOM 527  O O   . GLY A 1 199 ? 146.765 156.902 155.725 1.00 50.24  ? 120 GLY A O   1 
ATOM 528  N N   . GLY A 1 200 ? 145.956 156.003 153.828 1.00 41.25  ? 121 GLY A N   1 
ATOM 529  C CA  . GLY A 1 200 ? 147.272 155.562 153.395 1.00 40.58  ? 121 GLY A CA  1 
ATOM 530  C C   . GLY A 1 200 ? 148.184 156.719 153.037 1.00 39.80  ? 121 GLY A C   1 
ATOM 531  O O   . GLY A 1 200 ? 149.385 156.682 153.316 1.00 41.98  ? 121 GLY A O   1 
ATOM 532  N N   . LEU A 1 201 ? 147.628 157.755 152.401 1.00 39.52  ? 122 LEU A N   1 
ATOM 533  C CA  . LEU A 1 201 ? 148.394 158.969 152.138 1.00 38.67  ? 122 LEU A CA  1 
ATOM 534  C C   . LEU A 1 201 ? 148.788 159.663 153.433 1.00 45.50  ? 122 LEU A C   1 
ATOM 535  O O   . LEU A 1 201 ? 149.925 160.126 153.577 1.00 52.01  ? 122 LEU A O   1 
ATOM 536  C CB  . LEU A 1 201 ? 147.589 159.918 151.253 1.00 34.38  ? 122 LEU A CB  1 
ATOM 537  C CG  . LEU A 1 201 ? 148.278 161.241 150.926 1.00 37.24  ? 122 LEU A CG  1 
ATOM 538  C CD1 . LEU A 1 201 ? 149.552 160.996 150.143 1.00 42.66  ? 122 LEU A CD1 1 
ATOM 539  C CD2 . LEU A 1 201 ? 147.340 162.158 150.166 1.00 42.00  ? 122 LEU A CD2 1 
ATOM 540  N N   . VAL A 1 202 ? 147.855 159.751 154.384 1.00 42.89  ? 123 VAL A N   1 
ATOM 541  C CA  . VAL A 1 202 ? 148.170 160.305 155.698 1.00 42.18  ? 123 VAL A CA  1 
ATOM 542  C C   . VAL A 1 202 ? 149.157 159.403 156.428 1.00 46.62  ? 123 VAL A C   1 
ATOM 543  O O   . VAL A 1 202 ? 150.111 159.880 157.054 1.00 50.87  ? 123 VAL A O   1 
ATOM 544  C CB  . VAL A 1 202 ? 146.872 160.516 156.502 1.00 40.45  ? 123 VAL A CB  1 
ATOM 545  C CG1 . VAL A 1 202 ? 147.154 160.650 157.992 1.00 41.67  ? 123 VAL A CG1 1 
ATOM 546  C CG2 . VAL A 1 202 ? 146.131 161.738 155.990 1.00 41.46  ? 123 VAL A CG2 1 
ATOM 547  N N   . GLY A 1 203 ? 148.966 158.086 156.319 1.00 45.55  ? 124 GLY A N   1 
ATOM 548  C CA  . GLY A 1 203 ? 149.816 157.152 157.040 1.00 48.97  ? 124 GLY A CA  1 
ATOM 549  C C   . GLY A 1 203 ? 151.260 157.161 156.578 1.00 51.82  ? 124 GLY A C   1 
ATOM 550  O O   . GLY A 1 203 ? 152.173 156.973 157.384 1.00 56.87  ? 124 GLY A O   1 
ATOM 551  N N   . THR A 1 204 ? 151.488 157.375 155.278 1.00 51.66  ? 125 THR A N   1 
ATOM 552  C CA  . THR A 1 204 ? 152.850 157.377 154.746 1.00 53.86  ? 125 THR A CA  1 
ATOM 553  C C   . THR A 1 204 ? 153.664 158.549 155.284 1.00 56.24  ? 125 THR A C   1 
ATOM 554  O O   . THR A 1 204 ? 154.868 158.413 155.528 1.00 60.61  ? 125 THR A O   1 
ATOM 555  C CB  . THR A 1 204 ? 152.824 157.412 153.218 1.00 51.72  ? 125 THR A CB  1 
ATOM 556  O OG1 . THR A 1 204 ? 151.729 158.222 152.774 1.00 54.23  ? 125 THR A OG1 1 
ATOM 557  C CG2 . THR A 1 204 ? 152.677 156.007 152.654 1.00 51.54  ? 125 THR A CG2 1 
ATOM 558  N N   . LEU A 1 205 ? 153.029 159.709 155.465 1.00 55.81  ? 126 LEU A N   1 
ATOM 559  C CA  . LEU A 1 205 ? 153.735 160.861 156.016 1.00 60.60  ? 126 LEU A CA  1 
ATOM 560  C C   . LEU A 1 205 ? 154.081 160.663 157.486 1.00 64.84  ? 126 LEU A C   1 
ATOM 561  O O   . LEU A 1 205 ? 155.046 161.257 157.978 1.00 71.62  ? 126 LEU A O   1 
ATOM 562  C CB  . LEU A 1 205 ? 152.898 162.131 155.842 1.00 61.62  ? 126 LEU A CB  1 
ATOM 563  C CG  . LEU A 1 205 ? 152.157 162.367 154.523 1.00 62.04  ? 126 LEU A CG  1 
ATOM 564  C CD1 . LEU A 1 205 ? 151.465 163.719 154.544 1.00 61.28  ? 126 LEU A CD1 1 
ATOM 565  C CD2 . LEU A 1 205 ? 153.101 162.281 153.330 1.00 62.59  ? 126 LEU A CD2 1 
ATOM 566  N N   . ILE A 1 206 ? 153.303 159.844 158.198 1.00 62.80  ? 127 ILE A N   1 
ATOM 567  C CA  . ILE A 1 206 ? 153.503 159.667 159.633 1.00 64.34  ? 127 ILE A CA  1 
ATOM 568  C C   . ILE A 1 206 ? 154.798 158.906 159.913 1.00 69.96  ? 127 ILE A C   1 
ATOM 569  O O   . ILE A 1 206 ? 155.509 159.211 160.879 1.00 76.94  ? 127 ILE A O   1 
ATOM 570  C CB  . ILE A 1 206 ? 152.269 158.976 160.248 1.00 59.00  ? 127 ILE A CB  1 
ATOM 571  C CG1 . ILE A 1 206 ? 151.052 159.898 160.152 1.00 54.47  ? 127 ILE A CG1 1 
ATOM 572  C CG2 . ILE A 1 206 ? 152.491 158.642 161.706 1.00 59.88  ? 127 ILE A CG2 1 
ATOM 573  C CD1 . ILE A 1 206 ? 149.828 159.410 160.911 1.00 47.91  ? 127 ILE A CD1 1 
ATOM 574  N N   . VAL A 1 207 ? 155.147 157.939 159.052 1.00 68.00  ? 128 VAL A N   1 
ATOM 575  C CA  . VAL A 1 207 ? 156.290 157.052 159.295 1.00 71.45  ? 128 VAL A CA  1 
ATOM 576  C C   . VAL A 1 207 ? 157.608 157.815 159.351 1.00 78.78  ? 128 VAL A C   1 
ATOM 577  O O   . VAL A 1 207 ? 158.551 157.387 160.029 1.00 85.46  ? 128 VAL A O   1 
ATOM 578  C CB  . VAL A 1 207 ? 156.350 155.941 158.228 1.00 67.97  ? 128 VAL A CB  1 
ATOM 579  C CG1 . VAL A 1 207 ? 157.161 154.767 158.736 1.00 66.27  ? 128 VAL A CG1 1 
ATOM 580  C CG2 . VAL A 1 207 ? 154.965 155.477 157.865 1.00 63.95  ? 128 VAL A CG2 1 
ATOM 581  N N   . LYS A 1 208 ? 157.706 158.943 158.644 1.00 76.95  ? 129 LYS A N   1 
ATOM 582  C CA  . LYS A 1 208 ? 158.895 159.779 158.772 1.00 79.72  ? 129 LYS A CA  1 
ATOM 583  C C   . LYS A 1 208 ? 159.007 160.377 160.169 1.00 82.00  ? 129 LYS A C   1 
ATOM 584  O O   . LYS A 1 208 ? 160.119 160.570 160.675 1.00 85.31  ? 129 LYS A O   1 
ATOM 585  C CB  . LYS A 1 208 ? 158.887 160.881 157.712 1.00 78.38  ? 129 LYS A CB  1 
ATOM 586  C CG  . LYS A 1 208 ? 158.100 160.534 156.457 1.00 74.42  ? 129 LYS A CG  1 
ATOM 587  C CD  . LYS A 1 208 ? 158.207 161.634 155.410 1.00 73.08  ? 129 LYS A CD  1 
ATOM 588  C CE  . LYS A 1 208 ? 157.286 162.800 155.725 1.00 72.91  ? 129 LYS A CE  1 
ATOM 589  N NZ  . LYS A 1 208 ? 157.335 163.847 154.665 1.00 70.25  ? 129 LYS A NZ  1 
ATOM 590  N N   . MET A 1 209 ? 157.872 160.669 160.809 1.00 80.44  ? 130 MET A N   1 
ATOM 591  C CA  . MET A 1 209 ? 157.901 161.183 162.174 1.00 83.12  ? 130 MET A CA  1 
ATOM 592  C C   . MET A 1 209 ? 158.209 160.080 163.184 1.00 85.95  ? 130 MET A C   1 
ATOM 593  O O   . MET A 1 209 ? 158.946 160.311 164.150 1.00 92.69  ? 130 MET A O   1 
ATOM 594  C CB  . MET A 1 209 ? 156.574 161.864 162.505 1.00 83.69  ? 130 MET A CB  1 
ATOM 595  C CG  . MET A 1 209 ? 156.103 162.853 161.448 1.00 82.14  ? 130 MET A CG  1 
ATOM 596  S SD  . MET A 1 209 ? 157.450 163.523 160.454 1.00 93.95  ? 130 MET A SD  1 
ATOM 597  C CE  . MET A 1 209 ? 156.608 164.838 159.579 1.00 87.55  ? 130 MET A CE  1 
ATOM 598  N N   . ILE A 1 210 ? 157.646 158.882 162.991 1.00 82.82  ? 131 ILE A N   1 
ATOM 599  C CA  . ILE A 1 210 ? 157.907 157.783 163.922 1.00 84.90  ? 131 ILE A CA  1 
ATOM 600  C C   . ILE A 1 210 ? 159.344 157.295 163.799 1.00 91.88  ? 131 ILE A C   1 
ATOM 601  O O   . ILE A 1 210 ? 159.944 156.848 164.784 1.00 96.37  ? 131 ILE A O   1 
ATOM 602  C CB  . ILE A 1 210 ? 156.919 156.620 163.713 1.00 82.66  ? 131 ILE A CB  1 
ATOM 603  C CG1 . ILE A 1 210 ? 155.537 157.107 163.301 1.00 82.23  ? 131 ILE A CG1 1 
ATOM 604  C CG2 . ILE A 1 210 ? 156.806 155.783 164.973 1.00 86.90  ? 131 ILE A CG2 1 
ATOM 605  C CD1 . ILE A 1 210 ? 154.595 155.963 162.984 1.00 76.64  ? 131 ILE A CD1 1 
ATOM 606  N N   . GLY A 1 211 ? 159.910 157.356 162.590 1.00 91.09  ? 132 GLY A N   1 
ATOM 607  C CA  . GLY A 1 211 ? 161.210 156.763 162.317 1.00 94.72  ? 132 GLY A CA  1 
ATOM 608  C C   . GLY A 1 211 ? 162.358 157.365 163.101 1.00 99.61  ? 132 GLY A C   1 
ATOM 609  O O   . GLY A 1 211 ? 163.383 156.701 163.289 1.00 107.80 ? 132 GLY A O   1 
ATOM 610  N N   . LYS A 1 212 ? 162.214 158.603 163.563 1.00 95.19  ? 133 LYS A N   1 
ATOM 611  C CA  . LYS A 1 212 ? 163.232 159.227 164.393 1.00 95.85  ? 133 LYS A CA  1 
ATOM 612  C C   . LYS A 1 212 ? 162.990 159.039 165.887 1.00 97.38  ? 133 LYS A C   1 
ATOM 613  O O   . LYS A 1 212 ? 163.856 159.408 166.687 1.00 98.42  ? 133 LYS A O   1 
ATOM 614  C CB  . LYS A 1 212 ? 163.333 160.721 164.059 1.00 96.06  ? 133 LYS A CB  1 
ATOM 615  C CG  . LYS A 1 212 ? 162.319 161.602 164.763 1.00 96.44  ? 133 LYS A CG  1 
ATOM 616  C CD  . LYS A 1 212 ? 162.608 163.076 164.531 1.00 98.18  ? 133 LYS A CD  1 
ATOM 617  C CE  . LYS A 1 212 ? 163.554 163.627 165.587 1.00 95.67  ? 133 LYS A CE  1 
ATOM 618  N NZ  . LYS A 1 212 ? 163.028 163.437 166.968 1.00 89.21  ? 133 LYS A NZ  1 
ATOM 619  N N   . VAL A 1 213 ? 161.851 158.473 166.286 1.00 97.57  ? 134 VAL A N   1 
ATOM 620  C CA  . VAL A 1 213 ? 161.560 158.260 167.699 1.00 98.46  ? 134 VAL A CA  1 
ATOM 621  C C   . VAL A 1 213 ? 161.353 156.794 168.064 1.00 99.32  ? 134 VAL A C   1 
ATOM 622  O O   . VAL A 1 213 ? 161.447 156.455 169.256 1.00 103.37 ? 134 VAL A O   1 
ATOM 623  C CB  . VAL A 1 213 ? 160.341 159.092 168.163 1.00 95.25  ? 134 VAL A CB  1 
ATOM 624  C CG1 . VAL A 1 213 ? 160.444 160.535 167.704 1.00 95.00  ? 134 VAL A CG1 1 
ATOM 625  C CG2 . VAL A 1 213 ? 159.040 158.473 167.671 1.00 91.25  ? 134 VAL A CG2 1 
ATOM 626  N N   . LEU A 1 214 ? 161.077 155.904 167.114 1.00 95.87  ? 135 LEU A N   1 
ATOM 627  C CA  . LEU A 1 214 ? 160.709 154.531 167.432 1.00 92.91  ? 135 LEU A CA  1 
ATOM 628  C C   . LEU A 1 214 ? 161.430 153.562 166.506 1.00 96.70  ? 135 LEU A C   1 
ATOM 629  O O   . LEU A 1 214 ? 162.008 153.948 165.487 1.00 98.86  ? 135 LEU A O   1 
ATOM 630  C CB  . LEU A 1 214 ? 159.192 154.325 167.335 1.00 88.30  ? 135 LEU A CB  1 
ATOM 631  C CG  . LEU A 1 214 ? 158.385 154.166 168.627 1.00 86.57  ? 135 LEU A CG  1 
ATOM 632  C CD1 . LEU A 1 214 ? 157.097 153.409 168.350 1.00 80.06  ? 135 LEU A CD1 1 
ATOM 633  C CD2 . LEU A 1 214 ? 159.193 153.464 169.711 1.00 90.08  ? 135 LEU A CD2 1 
ATOM 634  N N   . GLY A 1 215 ? 161.371 152.283 166.871 1.00 95.80  ? 136 GLY A N   1 
ATOM 635  C CA  . GLY A 1 215 ? 162.040 151.232 166.134 1.00 93.58  ? 136 GLY A CA  1 
ATOM 636  C C   . GLY A 1 215 ? 161.225 150.731 164.961 1.00 91.80  ? 136 GLY A C   1 
ATOM 637  O O   . GLY A 1 215 ? 160.378 151.434 164.406 1.00 94.10  ? 136 GLY A O   1 
ATOM 638  N N   . ARG A 1 216 ? 161.514 149.495 164.561 1.00 91.62  ? 137 ARG A N   1 
ATOM 639  C CA  . ARG A 1 216 ? 160.737 148.809 163.536 1.00 90.92  ? 137 ARG A CA  1 
ATOM 640  C C   . ARG A 1 216 ? 159.706 147.861 164.132 1.00 87.07  ? 137 ARG A C   1 
ATOM 641  O O   . ARG A 1 216 ? 158.544 147.870 163.718 1.00 85.64  ? 137 ARG A O   1 
ATOM 642  C CB  . ARG A 1 216 ? 161.667 148.042 162.589 1.00 95.78  ? 137 ARG A CB  1 
ATOM 643  C CG  . ARG A 1 216 ? 162.561 148.928 161.740 1.00 97.30  ? 137 ARG A CG  1 
ATOM 644  C CD  . ARG A 1 216 ? 161.728 149.892 160.885 1.00 93.07  ? 137 ARG A CD  1 
ATOM 645  N NE  . ARG A 1 216 ? 162.404 150.437 159.707 1.00 94.50  ? 137 ARG A NE  1 
ATOM 646  C CZ  . ARG A 1 216 ? 163.548 151.114 159.687 1.00 99.91  ? 137 ARG A CZ  1 
ATOM 647  N NH1 . ARG A 1 216 ? 164.155 151.503 160.798 1.00 102.73 ? 137 ARG A NH1 1 
ATOM 648  N NH2 . ARG A 1 216 ? 164.077 151.451 158.515 1.00 103.11 ? 137 ARG A NH2 1 
ATOM 649  N N   . LYS A 1 217 ? 160.119 147.027 165.089 1.00 87.15  ? 138 LYS A N   1 
ATOM 650  C CA  . LYS A 1 217 ? 159.169 146.173 165.793 1.00 85.53  ? 138 LYS A CA  1 
ATOM 651  C C   . LYS A 1 217 ? 158.205 146.999 166.635 1.00 87.00  ? 138 LYS A C   1 
ATOM 652  O O   . LYS A 1 217 ? 157.003 146.711 166.676 1.00 88.65  ? 138 LYS A O   1 
ATOM 653  C CB  . LYS A 1 217 ? 159.916 145.169 166.669 1.00 89.04  ? 138 LYS A CB  1 
ATOM 654  C CG  . LYS A 1 217 ? 159.013 144.213 167.425 1.00 92.83  ? 138 LYS A CG  1 
ATOM 655  C CD  . LYS A 1 217 ? 159.786 143.416 168.460 1.00 99.79  ? 138 LYS A CD  1 
ATOM 656  C CE  . LYS A 1 217 ? 160.299 144.315 169.571 1.00 100.18 ? 138 LYS A CE  1 
ATOM 657  N NZ  . LYS A 1 217 ? 161.067 143.557 170.595 1.00 101.68 ? 138 LYS A NZ  1 
ATOM 658  N N   . HIS A 1 218 ? 158.714 148.032 167.313 1.00 88.05  ? 139 HIS A N   1 
ATOM 659  C CA  . HIS A 1 218 ? 157.860 148.870 168.148 1.00 83.59  ? 139 HIS A CA  1 
ATOM 660  C C   . HIS A 1 218 ? 156.906 149.715 167.317 1.00 80.54  ? 139 HIS A C   1 
ATOM 661  O O   . HIS A 1 218 ? 155.813 150.049 167.788 1.00 77.87  ? 139 HIS A O   1 
ATOM 662  C CB  . HIS A 1 218 ? 158.709 149.765 169.048 1.00 87.43  ? 139 HIS A CB  1 
ATOM 663  C CG  . HIS A 1 218 ? 159.548 149.011 170.030 1.00 92.54  ? 139 HIS A CG  1 
ATOM 664  N ND1 . HIS A 1 218 ? 160.872 148.705 169.799 1.00 96.58  ? 139 HIS A ND1 1 
ATOM 665  C CD2 . HIS A 1 218 ? 159.250 148.498 171.247 1.00 92.74  ? 139 HIS A CD2 1 
ATOM 666  C CE1 . HIS A 1 218 ? 161.354 148.038 170.833 1.00 99.60  ? 139 HIS A CE1 1 
ATOM 667  N NE2 . HIS A 1 218 ? 160.390 147.898 171.725 1.00 96.59  ? 139 HIS A NE2 1 
ATOM 668  N N   . THR A 1 219 ? 157.303 150.090 166.098 1.00 82.76  ? 140 THR A N   1 
ATOM 669  C CA  . THR A 1 219 ? 156.396 150.823 165.221 1.00 79.56  ? 140 THR A CA  1 
ATOM 670  C C   . THR A 1 219 ? 155.216 149.956 164.806 1.00 77.95  ? 140 THR A C   1 
ATOM 671  O O   . THR A 1 219 ? 154.065 150.394 164.874 1.00 75.19  ? 140 THR A O   1 
ATOM 672  C CB  . THR A 1 219 ? 157.140 151.338 163.989 1.00 76.29  ? 140 THR A CB  1 
ATOM 673  O OG1 . THR A 1 219 ? 158.218 152.185 164.402 1.00 84.23  ? 140 THR A OG1 1 
ATOM 674  C CG2 . THR A 1 219 ? 156.203 152.130 163.089 1.00 73.62  ? 140 THR A CG2 1 
ATOM 675  N N   . LEU A 1 220 ? 155.486 148.709 164.402 1.00 77.47  ? 141 LEU A N   1 
ATOM 676  C CA  . LEU A 1 220 ? 154.419 147.808 163.972 1.00 73.19  ? 141 LEU A CA  1 
ATOM 677  C C   . LEU A 1 220 ? 153.478 147.469 165.121 1.00 72.02  ? 141 LEU A C   1 
ATOM 678  O O   . LEU A 1 220 ? 152.269 147.312 164.916 1.00 72.72  ? 141 LEU A O   1 
ATOM 679  C CB  . LEU A 1 220 ? 155.012 146.533 163.375 1.00 75.95  ? 141 LEU A CB  1 
ATOM 680  C CG  . LEU A 1 220 ? 155.756 146.672 162.047 1.00 77.60  ? 141 LEU A CG  1 
ATOM 681  C CD1 . LEU A 1 220 ? 156.454 145.371 161.689 1.00 82.74  ? 141 LEU A CD1 1 
ATOM 682  C CD2 . LEU A 1 220 ? 154.800 147.091 160.945 1.00 74.61  ? 141 LEU A CD2 1 
ATOM 683  N N   . LEU A 1 221 ? 154.019 147.326 166.333 1.00 71.64  ? 142 LEU A N   1 
ATOM 684  C CA  . LEU A 1 221 ? 153.172 147.136 167.506 1.00 72.16  ? 142 LEU A CA  1 
ATOM 685  C C   . LEU A 1 221 ? 152.317 148.369 167.772 1.00 70.05  ? 142 LEU A C   1 
ATOM 686  O O   . LEU A 1 221 ? 151.119 148.255 168.055 1.00 70.15  ? 142 LEU A O   1 
ATOM 687  C CB  . LEU A 1 221 ? 154.028 146.810 168.730 1.00 80.02  ? 142 LEU A CB  1 
ATOM 688  C CG  . LEU A 1 221 ? 154.356 145.360 169.102 1.00 78.89  ? 142 LEU A CG  1 
ATOM 689  C CD1 . LEU A 1 221 ? 154.740 144.512 167.902 1.00 76.07  ? 142 LEU A CD1 1 
ATOM 690  C CD2 . LEU A 1 221 ? 155.464 145.342 170.139 1.00 88.15  ? 142 LEU A CD2 1 
ATOM 691  N N   . ALA A 1 222 ? 152.916 149.559 167.681 1.00 64.84  ? 143 ALA A N   1 
ATOM 692  C CA  . ALA A 1 222 ? 152.156 150.787 167.880 1.00 60.93  ? 143 ALA A CA  1 
ATOM 693  C C   . ALA A 1 222 ? 151.231 151.071 166.706 1.00 59.16  ? 143 ALA A C   1 
ATOM 694  O O   . ALA A 1 222 ? 150.218 151.758 166.871 1.00 59.59  ? 143 ALA A O   1 
ATOM 695  C CB  . ALA A 1 222 ? 153.103 151.965 168.102 1.00 65.48  ? 143 ALA A CB  1 
ATOM 696  N N   . ASN A 1 223 ? 151.568 150.563 165.518 1.00 62.46  ? 144 ASN A N   1 
ATOM 697  C CA  . ASN A 1 223 ? 150.711 150.752 164.353 1.00 60.57  ? 144 ASN A CA  1 
ATOM 698  C C   . ASN A 1 223 ? 149.413 149.969 164.515 1.00 57.24  ? 144 ASN A C   1 
ATOM 699  O O   . ASN A 1 223 ? 148.354 150.422 164.066 1.00 51.69  ? 144 ASN A O   1 
ATOM 700  C CB  . ASN A 1 223 ? 151.479 150.331 163.092 1.00 61.81  ? 144 ASN A CB  1 
ATOM 701  C CG  . ASN A 1 223 ? 150.587 149.971 161.930 1.00 61.03  ? 144 ASN A CG  1 
ATOM 702  O OD1 . ASN A 1 223 ? 149.647 150.691 161.610 1.00 58.84  ? 144 ASN A OD1 1 
ATOM 703  N ND2 . ASN A 1 223 ? 150.880 148.848 161.287 1.00 59.76  ? 144 ASN A ND2 1 
ATOM 704  N N   . ASN A 1 224 ? 149.467 148.821 165.198 1.00 60.15  ? 145 ASN A N   1 
ATOM 705  C CA  . ASN A 1 224 ? 148.289 147.995 165.445 1.00 57.15  ? 145 ASN A CA  1 
ATOM 706  C C   . ASN A 1 224 ? 147.265 148.660 166.354 1.00 54.07  ? 145 ASN A C   1 
ATOM 707  O O   . ASN A 1 224 ? 146.139 148.161 166.449 1.00 50.58  ? 145 ASN A O   1 
ATOM 708  C CB  . ASN A 1 224 ? 148.702 146.656 166.050 1.00 59.10  ? 145 ASN A CB  1 
ATOM 709  C CG  . ASN A 1 224 ? 149.058 145.633 165.000 1.00 64.99  ? 145 ASN A CG  1 
ATOM 710  O OD1 . ASN A 1 224 ? 148.945 145.890 163.802 1.00 61.62  ? 145 ASN A OD1 1 
ATOM 711  N ND2 . ASN A 1 224 ? 149.481 144.457 165.443 1.00 69.72  ? 145 ASN A ND2 1 
ATOM 712  N N   . GLY A 1 225 ? 147.631 149.745 167.040 1.00 53.07  ? 146 GLY A N   1 
ATOM 713  C CA  . GLY A 1 225 ? 146.634 150.544 167.728 1.00 49.16  ? 146 GLY A CA  1 
ATOM 714  C C   . GLY A 1 225 ? 145.628 151.157 166.777 1.00 45.07  ? 146 GLY A C   1 
ATOM 715  O O   . GLY A 1 225 ? 144.458 151.323 167.128 1.00 44.63  ? 146 GLY A O   1 
ATOM 716  N N   . PHE A 1 226 ? 146.066 151.502 165.565 1.00 47.87  ? 147 PHE A N   1 
ATOM 717  C CA  . PHE A 1 226 ? 145.138 151.972 164.543 1.00 51.05  ? 147 PHE A CA  1 
ATOM 718  C C   . PHE A 1 226 ? 144.238 150.845 164.052 1.00 46.44  ? 147 PHE A C   1 
ATOM 719  O O   . PHE A 1 226 ? 143.066 151.075 163.737 1.00 45.08  ? 147 PHE A O   1 
ATOM 720  C CB  . PHE A 1 226 ? 145.911 152.582 163.374 1.00 49.81  ? 147 PHE A CB  1 
ATOM 721  C CG  . PHE A 1 226 ? 146.481 153.939 163.664 1.00 47.66  ? 147 PHE A CG  1 
ATOM 722  C CD1 . PHE A 1 226 ? 145.650 155.035 163.817 1.00 42.98  ? 147 PHE A CD1 1 
ATOM 723  C CD2 . PHE A 1 226 ? 147.850 154.119 163.780 1.00 48.49  ? 147 PHE A CD2 1 
ATOM 724  C CE1 . PHE A 1 226 ? 146.171 156.286 164.082 1.00 44.70  ? 147 PHE A CE1 1 
ATOM 725  C CE2 . PHE A 1 226 ? 148.379 155.368 164.045 1.00 48.16  ? 147 PHE A CE2 1 
ATOM 726  C CZ  . PHE A 1 226 ? 147.538 156.453 164.196 1.00 48.94  ? 147 PHE A CZ  1 
ATOM 727  N N   . ALA A 1 227 ? 144.775 149.625 163.968 1.00 44.45  ? 148 ALA A N   1 
ATOM 728  C CA  . ALA A 1 227 ? 144.014 148.504 163.424 1.00 42.32  ? 148 ALA A CA  1 
ATOM 729  C C   . ALA A 1 227 ? 142.869 148.102 164.347 1.00 43.88  ? 148 ALA A C   1 
ATOM 730  O O   . ALA A 1 227 ? 141.749 147.852 163.887 1.00 43.55  ? 148 ALA A O   1 
ATOM 731  C CB  . ALA A 1 227 ? 144.942 147.316 163.172 1.00 45.32  ? 148 ALA A CB  1 
ATOM 732  N N   . ILE A 1 228 ? 143.134 148.023 165.652 1.00 47.39  ? 149 ILE A N   1 
ATOM 733  C CA  . ILE A 1 228 ? 142.095 147.639 166.604 1.00 46.42  ? 149 ILE A CA  1 
ATOM 734  C C   . ILE A 1 228 ? 141.066 148.755 166.760 1.00 43.03  ? 149 ILE A C   1 
ATOM 735  O O   . ILE A 1 228 ? 139.858 148.498 166.819 1.00 44.05  ? 149 ILE A O   1 
ATOM 736  C CB  . ILE A 1 228 ? 142.734 147.249 167.951 1.00 47.14  ? 149 ILE A CB  1 
ATOM 737  C CG1 . ILE A 1 228 ? 143.567 145.976 167.790 1.00 46.15  ? 149 ILE A CG1 1 
ATOM 738  C CG2 . ILE A 1 228 ? 141.678 147.038 169.023 1.00 42.48  ? 149 ILE A CG2 1 
ATOM 739  C CD1 . ILE A 1 228 ? 144.465 145.681 168.967 1.00 50.07  ? 149 ILE A CD1 1 
ATOM 740  N N   . SER A 1 229 ? 141.527 150.010 166.815 1.00 40.68  ? 150 SER A N   1 
ATOM 741  C CA  . SER A 1 229 ? 140.618 151.138 167.007 1.00 39.62  ? 150 SER A CA  1 
ATOM 742  C C   . SER A 1 229 ? 139.683 151.319 165.818 1.00 38.75  ? 150 SER A C   1 
ATOM 743  O O   . SER A 1 229 ? 138.502 151.634 165.995 1.00 43.33  ? 150 SER A O   1 
ATOM 744  C CB  . SER A 1 229 ? 141.413 152.419 167.250 1.00 46.32  ? 150 SER A CB  1 
ATOM 745  O OG  . SER A 1 229 ? 142.158 152.337 168.452 1.00 58.30  ? 150 SER A OG  1 
ATOM 746  N N   . ALA A 1 230 ? 140.191 151.134 164.600 1.00 36.15  ? 151 ALA A N   1 
ATOM 747  C CA  . ALA A 1 230 ? 139.347 151.281 163.421 1.00 36.12  ? 151 ALA A CA  1 
ATOM 748  C C   . ALA A 1 230 ? 138.407 150.099 163.233 1.00 36.14  ? 151 ALA A C   1 
ATOM 749  O O   . ALA A 1 230 ? 137.284 150.283 162.753 1.00 34.75  ? 151 ALA A O   1 
ATOM 750  C CB  . ALA A 1 230 ? 140.208 151.462 162.176 1.00 38.98  ? 151 ALA A CB  1 
ATOM 751  N N   . ALA A 1 231 ? 138.848 148.889 163.592 1.00 37.63  ? 152 ALA A N   1 
ATOM 752  C CA  . ALA A 1 231 ? 137.984 147.717 163.485 1.00 36.32  ? 152 ALA A CA  1 
ATOM 753  C C   . ALA A 1 231 ? 136.793 147.821 164.429 1.00 38.26  ? 152 ALA A C   1 
ATOM 754  O O   . ALA A 1 231 ? 135.681 147.407 164.084 1.00 38.28  ? 152 ALA A O   1 
ATOM 755  C CB  . ALA A 1 231 ? 138.781 146.447 163.770 1.00 37.21  ? 152 ALA A CB  1 
ATOM 756  N N   . LEU A 1 232 ? 137.009 148.365 165.628 1.00 38.05  ? 153 LEU A N   1 
ATOM 757  C CA  . LEU A 1 232 ? 135.902 148.573 166.553 1.00 33.02  ? 153 LEU A CA  1 
ATOM 758  C C   . LEU A 1 232 ? 134.961 149.668 166.071 1.00 34.14  ? 153 LEU A C   1 
ATOM 759  O O   . LEU A 1 232 ? 133.778 149.662 166.424 1.00 37.27  ? 153 LEU A O   1 
ATOM 760  C CB  . LEU A 1 232 ? 136.435 148.911 167.945 1.00 34.03  ? 153 LEU A CB  1 
ATOM 761  C CG  . LEU A 1 232 ? 137.146 147.781 168.691 1.00 40.70  ? 153 LEU A CG  1 
ATOM 762  C CD1 . LEU A 1 232 ? 137.740 148.289 169.994 1.00 46.39  ? 153 LEU A CD1 1 
ATOM 763  C CD2 . LEU A 1 232 ? 136.196 146.623 168.945 1.00 38.41  ? 153 LEU A CD2 1 
ATOM 764  N N   . LEU A 1 233 ? 135.461 150.619 165.278 1.00 32.06  ? 154 LEU A N   1 
ATOM 765  C CA  . LEU A 1 233 ? 134.602 151.691 164.786 1.00 32.41  ? 154 LEU A CA  1 
ATOM 766  C C   . LEU A 1 233 ? 133.674 151.208 163.677 1.00 35.34  ? 154 LEU A C   1 
ATOM 767  O O   . LEU A 1 233 ? 132.493 151.570 163.653 1.00 37.63  ? 154 LEU A O   1 
ATOM 768  C CB  . LEU A 1 233 ? 135.447 152.869 164.306 1.00 32.52  ? 154 LEU A CB  1 
ATOM 769  C CG  . LEU A 1 233 ? 136.012 153.766 165.407 1.00 33.42  ? 154 LEU A CG  1 
ATOM 770  C CD1 . LEU A 1 233 ? 137.033 154.730 164.837 1.00 32.01  ? 154 LEU A CD1 1 
ATOM 771  C CD2 . LEU A 1 233 ? 134.895 154.518 166.110 1.00 30.84  ? 154 LEU A CD2 1 
ATOM 772  N N   . MET A 1 234 ? 134.185 150.400 162.745 1.00 34.28  ? 155 MET A N   1 
ATOM 773  C CA  . MET A 1 234 ? 133.336 149.929 161.654 1.00 34.00  ? 155 MET A CA  1 
ATOM 774  C C   . MET A 1 234 ? 132.366 148.851 162.124 1.00 39.84  ? 155 MET A C   1 
ATOM 775  O O   . MET A 1 234 ? 131.200 148.840 161.713 1.00 40.84  ? 155 MET A O   1 
ATOM 776  C CB  . MET A 1 234 ? 134.181 149.406 160.493 1.00 31.44  ? 155 MET A CB  1 
ATOM 777  C CG  . MET A 1 234 ? 134.957 150.474 159.744 1.00 35.42  ? 155 MET A CG  1 
ATOM 778  S SD  . MET A 1 234 ? 136.116 149.765 158.562 1.00 41.70  ? 155 MET A SD  1 
ATOM 779  C CE  . MET A 1 234 ? 137.578 149.618 159.569 1.00 35.85  ? 155 MET A CE  1 
ATOM 780  N N   . ALA A 1 235 ? 132.828 147.934 162.978 1.00 39.07  ? 156 ALA A N   1 
ATOM 781  C CA  . ALA A 1 235 ? 131.977 146.841 163.436 1.00 34.78  ? 156 ALA A CA  1 
ATOM 782  C C   . ALA A 1 235 ? 130.856 147.314 164.352 1.00 39.36  ? 156 ALA A C   1 
ATOM 783  O O   . ALA A 1 235 ? 129.825 146.642 164.445 1.00 43.44  ? 156 ALA A O   1 
ATOM 784  C CB  . ALA A 1 235 ? 132.814 145.781 164.150 1.00 32.99  ? 156 ALA A CB  1 
ATOM 785  N N   . CYS A 1 236 ? 131.032 148.448 165.027 1.00 40.78  ? 157 CYS A N   1 
ATOM 786  C CA  . CYS A 1 236 ? 130.006 149.013 165.890 1.00 44.77  ? 157 CYS A CA  1 
ATOM 787  C C   . CYS A 1 236 ? 129.231 150.137 165.216 1.00 45.79  ? 157 CYS A C   1 
ATOM 788  O O   . CYS A 1 236 ? 128.504 150.866 165.897 1.00 50.92  ? 157 CYS A O   1 
ATOM 789  C CB  . CYS A 1 236 ? 130.628 149.517 167.192 1.00 40.87  ? 157 CYS A CB  1 
ATOM 790  S SG  . CYS A 1 236 ? 131.379 148.225 168.207 1.00 42.53  ? 157 CYS A SG  1 
ATOM 791  N N   . SER A 1 237 ? 129.384 150.304 163.900 1.00 38.89  ? 158 SER A N   1 
ATOM 792  C CA  . SER A 1 237 ? 128.677 151.368 163.195 1.00 41.42  ? 158 SER A CA  1 
ATOM 793  C C   . SER A 1 237 ? 127.173 151.125 163.171 1.00 47.81  ? 158 SER A C   1 
ATOM 794  O O   . SER A 1 237 ? 126.385 152.063 163.345 1.00 50.54  ? 158 SER A O   1 
ATOM 795  C CB  . SER A 1 237 ? 129.216 151.501 161.772 1.00 40.03  ? 158 SER A CB  1 
ATOM 796  O OG  . SER A 1 237 ? 128.464 152.446 161.033 1.00 43.48  ? 158 SER A OG  1 
ATOM 797  N N   . LEU A 1 238 ? 126.754 149.878 162.951 1.00 49.28  ? 159 LEU A N   1 
ATOM 798  C CA  . LEU A 1 238 ? 125.328 149.576 162.901 1.00 47.67  ? 159 LEU A CA  1 
ATOM 799  C C   . LEU A 1 238 ? 124.718 149.563 164.299 1.00 51.39  ? 159 LEU A C   1 
ATOM 800  O O   . LEU A 1 238 ? 123.578 150.005 164.484 1.00 54.35  ? 159 LEU A O   1 
ATOM 801  C CB  . LEU A 1 238 ? 125.104 148.235 162.197 1.00 43.18  ? 159 LEU A CB  1 
ATOM 802  C CG  . LEU A 1 238 ? 123.697 147.634 162.102 1.00 45.87  ? 159 LEU A CG  1 
ATOM 803  C CD1 . LEU A 1 238 ? 122.661 148.663 161.660 1.00 52.46  ? 159 LEU A CD1 1 
ATOM 804  C CD2 . LEU A 1 238 ? 123.687 146.443 161.163 1.00 44.39  ? 159 LEU A CD2 1 
ATOM 805  N N   . GLN A 1 239 ? 125.462 149.058 165.289 1.00 51.72  ? 160 GLN A N   1 
ATOM 806  C CA  . GLN A 1 239 ? 124.953 149.005 166.656 1.00 53.50  ? 160 GLN A CA  1 
ATOM 807  C C   . GLN A 1 239 ? 124.765 150.402 167.237 1.00 54.79  ? 160 GLN A C   1 
ATOM 808  O O   . GLN A 1 239 ? 123.790 150.655 167.954 1.00 60.35  ? 160 GLN A O   1 
ATOM 809  C CB  . GLN A 1 239 ? 125.890 148.175 167.533 1.00 53.43  ? 160 GLN A CB  1 
ATOM 810  C CG  . GLN A 1 239 ? 125.566 146.688 167.538 1.00 58.60  ? 160 GLN A CG  1 
ATOM 811  C CD  . GLN A 1 239 ? 126.770 145.824 167.857 1.00 64.75  ? 160 GLN A CD  1 
ATOM 812  O OE1 . GLN A 1 239 ? 127.259 145.812 168.987 1.00 64.61  ? 160 GLN A OE1 1 
ATOM 813  N NE2 . GLN A 1 239 ? 127.254 145.091 166.860 1.00 56.87  ? 160 GLN A NE2 1 
ATOM 814  N N   . ALA A 1 240 ? 125.683 151.322 166.939 1.00 49.12  ? 161 ALA A N   1 
ATOM 815  C CA  . ALA A 1 240 ? 125.531 152.699 167.390 1.00 53.23  ? 161 ALA A CA  1 
ATOM 816  C C   . ALA A 1 240 ? 124.529 153.481 166.554 1.00 56.20  ? 161 ALA A C   1 
ATOM 817  O O   . ALA A 1 240 ? 124.088 154.553 166.984 1.00 65.21  ? 161 ALA A O   1 
ATOM 818  C CB  . ALA A 1 240 ? 126.881 153.415 167.371 1.00 52.17  ? 161 ALA A CB  1 
ATOM 819  N N   . GLY A 1 241 ? 124.161 152.976 165.380 1.00 53.69  ? 162 GLY A N   1 
ATOM 820  C CA  . GLY A 1 241 ? 123.180 153.646 164.552 1.00 55.41  ? 162 GLY A CA  1 
ATOM 821  C C   . GLY A 1 241 ? 123.662 154.908 163.879 1.00 54.62  ? 162 GLY A C   1 
ATOM 822  O O   . GLY A 1 241 ? 122.842 155.748 163.502 1.00 57.36  ? 162 GLY A O   1 
ATOM 823  N N   . ALA A 1 242 ? 124.972 155.068 163.709 1.00 49.51  ? 163 ALA A N   1 
ATOM 824  C CA  . ALA A 1 242 ? 125.539 156.229 163.039 1.00 49.21  ? 163 ALA A CA  1 
ATOM 825  C C   . ALA A 1 242 ? 126.523 155.753 161.984 1.00 48.75  ? 163 ALA A C   1 
ATOM 826  O O   . ALA A 1 242 ? 127.420 154.959 162.281 1.00 46.46  ? 163 ALA A O   1 
ATOM 827  C CB  . ALA A 1 242 ? 126.234 157.165 164.033 1.00 54.06  ? 163 ALA A CB  1 
ATOM 828  N N   . PHE A 1 243 ? 126.353 156.237 160.754 1.00 49.86  ? 164 PHE A N   1 
ATOM 829  C CA  . PHE A 1 243 ? 127.195 155.799 159.650 1.00 46.35  ? 164 PHE A CA  1 
ATOM 830  C C   . PHE A 1 243 ? 128.507 156.565 159.558 1.00 46.07  ? 164 PHE A C   1 
ATOM 831  O O   . PHE A 1 243 ? 129.347 156.216 158.721 1.00 42.23  ? 164 PHE A O   1 
ATOM 832  C CB  . PHE A 1 243 ? 126.409 155.891 158.331 1.00 41.24  ? 164 PHE A CB  1 
ATOM 833  C CG  . PHE A 1 243 ? 126.007 157.291 157.932 1.00 41.73  ? 164 PHE A CG  1 
ATOM 834  C CD1 . PHE A 1 243 ? 126.876 158.123 157.238 1.00 45.92  ? 164 PHE A CD1 1 
ATOM 835  C CD2 . PHE A 1 243 ? 124.750 157.771 158.254 1.00 47.26  ? 164 PHE A CD2 1 
ATOM 836  C CE1 . PHE A 1 243 ? 126.498 159.400 156.876 1.00 52.85  ? 164 PHE A CE1 1 
ATOM 837  C CE2 . PHE A 1 243 ? 124.366 159.049 157.895 1.00 54.69  ? 164 PHE A CE2 1 
ATOM 838  C CZ  . PHE A 1 243 ? 125.241 159.863 157.206 1.00 55.72  ? 164 PHE A CZ  1 
ATOM 839  N N   . GLU A 1 244 ? 128.695 157.604 160.375 1.00 49.24  ? 165 GLU A N   1 
ATOM 840  C CA  . GLU A 1 244 ? 129.937 158.367 160.329 1.00 45.15  ? 165 GLU A CA  1 
ATOM 841  C C   . GLU A 1 244 ? 131.117 157.555 160.841 1.00 40.81  ? 165 GLU A C   1 
ATOM 842  O O   . GLU A 1 244 ? 132.250 157.773 160.399 1.00 36.65  ? 165 GLU A O   1 
ATOM 843  C CB  . GLU A 1 244 ? 129.798 159.657 161.133 1.00 49.42  ? 165 GLU A CB  1 
ATOM 844  C CG  . GLU A 1 244 ? 128.870 160.677 160.505 1.00 55.11  ? 165 GLU A CG  1 
ATOM 845  C CD  . GLU A 1 244 ? 127.541 160.771 161.220 1.00 58.06  ? 165 GLU A CD  1 
ATOM 846  O OE1 . GLU A 1 244 ? 127.331 160.016 162.191 1.00 53.94  ? 165 GLU A OE1 1 
ATOM 847  O OE2 . GLU A 1 244 ? 126.708 161.604 160.812 1.00 65.87  ? 165 GLU A OE2 1 
ATOM 848  N N   . MET A 1 245 ? 130.876 156.622 161.767 1.00 39.18  ? 166 MET A N   1 
ATOM 849  C CA  . MET A 1 245 ? 131.959 155.798 162.290 1.00 34.11  ? 166 MET A CA  1 
ATOM 850  C C   . MET A 1 245 ? 132.516 154.857 161.231 1.00 35.13  ? 166 MET A C   1 
ATOM 851  O O   . MET A 1 245 ? 133.684 154.464 161.309 1.00 41.62  ? 166 MET A O   1 
ATOM 852  C CB  . MET A 1 245 ? 131.482 155.003 163.503 1.00 30.83  ? 166 MET A CB  1 
ATOM 853  C CG  . MET A 1 245 ? 130.968 155.861 164.640 1.00 37.43  ? 166 MET A CG  1 
ATOM 854  S SD  . MET A 1 245 ? 129.603 155.084 165.516 1.00 57.15  ? 166 MET A SD  1 
ATOM 855  C CE  . MET A 1 245 ? 130.450 153.704 166.280 1.00 41.27  ? 166 MET A CE  1 
ATOM 856  N N   . LEU A 1 246 ? 131.698 154.478 160.248 1.00 32.80  ? 167 LEU A N   1 
ATOM 857  C CA  . LEU A 1 246 ? 132.191 153.644 159.158 1.00 33.30  ? 167 LEU A CA  1 
ATOM 858  C C   . LEU A 1 246 ? 133.179 154.405 158.281 1.00 33.24  ? 167 LEU A C   1 
ATOM 859  O O   . LEU A 1 246 ? 134.202 153.850 157.866 1.00 33.67  ? 167 LEU A O   1 
ATOM 860  C CB  . LEU A 1 246 ? 131.018 153.125 158.329 1.00 35.99  ? 167 LEU A CB  1 
ATOM 861  C CG  . LEU A 1 246 ? 131.320 152.004 157.336 1.00 31.42  ? 167 LEU A CG  1 
ATOM 862  C CD1 . LEU A 1 246 ? 131.696 150.735 158.064 1.00 30.73  ? 167 LEU A CD1 1 
ATOM 863  C CD2 . LEU A 1 246 ? 130.121 151.759 156.458 1.00 32.74  ? 167 LEU A CD2 1 
ATOM 864  N N   . ILE A 1 247 ? 132.891 155.676 157.989 1.00 34.18  ? 168 ILE A N   1 
ATOM 865  C CA  . ILE A 1 247 ? 133.800 156.485 157.181 1.00 32.33  ? 168 ILE A CA  1 
ATOM 866  C C   . ILE A 1 247 ? 135.075 156.794 157.959 1.00 35.05  ? 168 ILE A C   1 
ATOM 867  O O   . ILE A 1 247 ? 136.184 156.715 157.417 1.00 33.10  ? 168 ILE A O   1 
ATOM 868  C CB  . ILE A 1 247 ? 133.094 157.770 156.714 1.00 33.12  ? 168 ILE A CB  1 
ATOM 869  C CG1 . ILE A 1 247 ? 131.876 157.428 155.860 1.00 34.58  ? 168 ILE A CG1 1 
ATOM 870  C CG2 . ILE A 1 247 ? 134.041 158.648 155.915 1.00 31.00  ? 168 ILE A CG2 1 
ATOM 871  C CD1 . ILE A 1 247 ? 131.018 158.624 155.524 1.00 41.49  ? 168 ILE A CD1 1 
ATOM 872  N N   . VAL A 1 248 ? 134.936 157.149 159.239 1.00 36.02  ? 169 VAL A N   1 
ATOM 873  C CA  . VAL A 1 248 ? 136.099 157.395 160.089 1.00 30.98  ? 169 VAL A CA  1 
ATOM 874  C C   . VAL A 1 248 ? 136.875 156.103 160.320 1.00 33.08  ? 169 VAL A C   1 
ATOM 875  O O   . VAL A 1 248 ? 138.111 156.107 160.380 1.00 39.90  ? 169 VAL A O   1 
ATOM 876  C CB  . VAL A 1 248 ? 135.650 158.051 161.409 1.00 26.85  ? 169 VAL A CB  1 
ATOM 877  C CG1 . VAL A 1 248 ? 136.820 158.251 162.356 1.00 30.74  ? 169 VAL A CG1 1 
ATOM 878  C CG2 . VAL A 1 248 ? 134.985 159.385 161.129 1.00 27.67  ? 169 VAL A CG2 1 
ATOM 879  N N   . GLY A 1 249 ? 136.166 154.977 160.433 1.00 27.95  ? 170 GLY A N   1 
ATOM 880  C CA  . GLY A 1 249 ? 136.841 153.697 160.587 1.00 29.67  ? 170 GLY A CA  1 
ATOM 881  C C   . GLY A 1 249 ? 137.671 153.312 159.377 1.00 36.02  ? 170 GLY A C   1 
ATOM 882  O O   . GLY A 1 249 ? 138.764 152.759 159.515 1.00 40.59  ? 170 GLY A O   1 
ATOM 883  N N   . ARG A 1 250 ? 137.159 153.590 158.174 1.00 36.42  ? 171 ARG A N   1 
ATOM 884  C CA  . ARG A 1 250 ? 137.922 153.325 156.956 1.00 33.64  ? 171 ARG A CA  1 
ATOM 885  C C   . ARG A 1 250 ? 139.170 154.195 156.881 1.00 36.93  ? 171 ARG A C   1 
ATOM 886  O O   . ARG A 1 250 ? 140.228 153.738 156.431 1.00 39.09  ? 171 ARG A O   1 
ATOM 887  C CB  . ARG A 1 250 ? 137.042 153.550 155.727 1.00 30.95  ? 171 ARG A CB  1 
ATOM 888  C CG  . ARG A 1 250 ? 136.007 152.471 155.487 1.00 34.65  ? 171 ARG A CG  1 
ATOM 889  C CD  . ARG A 1 250 ? 136.634 151.204 154.936 1.00 40.64  ? 171 ARG A CD  1 
ATOM 890  N NE  . ARG A 1 250 ? 137.129 151.390 153.577 1.00 37.16  ? 171 ARG A NE  1 
ATOM 891  C CZ  . ARG A 1 250 ? 137.862 150.503 152.920 1.00 36.75  ? 171 ARG A CZ  1 
ATOM 892  N NH1 . ARG A 1 250 ? 138.211 149.351 153.469 1.00 41.45  ? 171 ARG A NH1 1 
ATOM 893  N NH2 . ARG A 1 250 ? 138.250 150.774 151.677 1.00 34.54  ? 171 ARG A NH2 1 
ATOM 894  N N   . PHE A 1 251 ? 139.059 155.459 157.300 1.00 36.09  ? 172 PHE A N   1 
ATOM 895  C CA  . PHE A 1 251 ? 140.198 156.371 157.259 1.00 35.74  ? 172 PHE A CA  1 
ATOM 896  C C   . PHE A 1 251 ? 141.297 155.937 158.222 1.00 36.01  ? 172 PHE A C   1 
ATOM 897  O O   . PHE A 1 251 ? 142.486 156.011 157.892 1.00 36.40  ? 172 PHE A O   1 
ATOM 898  C CB  . PHE A 1 251 ? 139.733 157.791 157.579 1.00 34.27  ? 172 PHE A CB  1 
ATOM 899  C CG  . PHE A 1 251 ? 140.846 158.795 157.656 1.00 37.26  ? 172 PHE A CG  1 
ATOM 900  C CD1 . PHE A 1 251 ? 141.556 159.151 156.523 1.00 37.75  ? 172 PHE A CD1 1 
ATOM 901  C CD2 . PHE A 1 251 ? 141.176 159.391 158.861 1.00 37.46  ? 172 PHE A CD2 1 
ATOM 902  C CE1 . PHE A 1 251 ? 142.577 160.079 156.591 1.00 38.14  ? 172 PHE A CE1 1 
ATOM 903  C CE2 . PHE A 1 251 ? 142.197 160.319 158.935 1.00 38.49  ? 172 PHE A CE2 1 
ATOM 904  C CZ  . PHE A 1 251 ? 142.897 160.663 157.799 1.00 39.05  ? 172 PHE A CZ  1 
ATOM 905  N N   . ILE A 1 252 ? 140.919 155.488 159.420 1.00 36.24  ? 173 ILE A N   1 
ATOM 906  C CA  . ILE A 1 252 ? 141.913 155.095 160.415 1.00 39.18  ? 173 ILE A CA  1 
ATOM 907  C C   . ILE A 1 252 ? 142.573 153.769 160.037 1.00 42.50  ? 173 ILE A C   1 
ATOM 908  O O   . ILE A 1 252 ? 143.773 153.578 160.272 1.00 48.50  ? 173 ILE A O   1 
ATOM 909  C CB  . ILE A 1 252 ? 141.262 155.067 161.812 1.00 31.81  ? 173 ILE A CB  1 
ATOM 910  C CG1 . ILE A 1 252 ? 140.864 156.484 162.220 1.00 29.36  ? 173 ILE A CG1 1 
ATOM 911  C CG2 . ILE A 1 252 ? 142.202 154.515 162.865 1.00 33.57  ? 173 ILE A CG2 1 
ATOM 912  C CD1 . ILE A 1 252 ? 139.992 156.546 163.441 1.00 32.37  ? 173 ILE A CD1 1 
ATOM 913  N N   . MET A 1 253 ? 141.824 152.846 159.423 1.00 35.65  ? 174 MET A N   1 
ATOM 914  C CA  . MET A 1 253 ? 142.442 151.625 158.910 1.00 36.59  ? 174 MET A CA  1 
ATOM 915  C C   . MET A 1 253 ? 143.395 151.929 157.761 1.00 40.07  ? 174 MET A C   1 
ATOM 916  O O   . MET A 1 253 ? 144.401 151.232 157.591 1.00 45.76  ? 174 MET A O   1 
ATOM 917  C CB  . MET A 1 253 ? 141.371 150.628 158.458 1.00 39.22  ? 174 MET A CB  1 
ATOM 918  C CG  . MET A 1 253 ? 141.193 149.384 159.348 1.00 39.77  ? 174 MET A CG  1 
ATOM 919  S SD  . MET A 1 253 ? 142.552 148.275 159.810 1.00 40.49  ? 174 MET A SD  1 
ATOM 920  C CE  . MET A 1 253 ? 143.596 148.236 158.359 1.00 40.51  ? 174 MET A CE  1 
ATOM 921  N N   . GLY A 1 254 ? 143.098 152.959 156.967 1.00 39.22  ? 175 GLY A N   1 
ATOM 922  C CA  . GLY A 1 254 ? 144.038 153.385 155.943 1.00 40.68  ? 175 GLY A CA  1 
ATOM 923  C C   . GLY A 1 254 ? 145.352 153.869 156.523 1.00 42.93  ? 175 GLY A C   1 
ATOM 924  O O   . GLY A 1 254 ? 146.416 153.654 155.939 1.00 47.04  ? 175 GLY A O   1 
ATOM 925  N N   . ILE A 1 255 ? 145.291 154.539 157.678 1.00 39.87  ? 176 ILE A N   1 
ATOM 926  C CA  . ILE A 1 255 ? 146.504 154.942 158.384 1.00 36.73  ? 176 ILE A CA  1 
ATOM 927  C C   . ILE A 1 255 ? 147.292 153.715 158.821 1.00 39.66  ? 176 ILE A C   1 
ATOM 928  O O   . ILE A 1 255 ? 148.528 153.699 158.763 1.00 44.41  ? 176 ILE A O   1 
ATOM 929  C CB  . ILE A 1 255 ? 146.143 155.854 159.573 1.00 36.13  ? 176 ILE A CB  1 
ATOM 930  C CG1 . ILE A 1 255 ? 145.498 157.144 159.069 1.00 37.80  ? 176 ILE A CG1 1 
ATOM 931  C CG2 . ILE A 1 255 ? 147.365 156.184 160.413 1.00 41.68  ? 176 ILE A CG2 1 
ATOM 932  C CD1 . ILE A 1 255 ? 144.985 158.040 160.169 1.00 39.91  ? 176 ILE A CD1 1 
ATOM 933  N N   . ASP A 1 256 ? 146.589 152.661 159.248 1.00 39.44  ? 177 ASP A N   1 
ATOM 934  C CA  . ASP A 1 256 ? 147.258 151.405 159.572 1.00 43.67  ? 177 ASP A CA  1 
ATOM 935  C C   . ASP A 1 256 ? 147.920 150.798 158.343 1.00 48.46  ? 177 ASP A C   1 
ATOM 936  O O   . ASP A 1 256 ? 149.057 150.322 158.417 1.00 55.07  ? 177 ASP A O   1 
ATOM 937  C CB  . ASP A 1 256 ? 146.265 150.411 160.173 1.00 46.01  ? 177 ASP A CB  1 
ATOM 938  C CG  . ASP A 1 256 ? 146.860 149.021 160.340 1.00 46.65  ? 177 ASP A CG  1 
ATOM 939  O OD1 . ASP A 1 256 ? 147.594 148.797 161.321 1.00 49.56  ? 177 ASP A OD1 1 
ATOM 940  O OD2 . ASP A 1 256 ? 146.623 148.155 159.475 1.00 47.62  ? 177 ASP A OD2 1 
ATOM 941  N N   . GLY A 1 257 ? 147.222 150.809 157.205 1.00 46.28  ? 178 GLY A N   1 
ATOM 942  C CA  . GLY A 1 257 ? 147.771 150.210 155.997 1.00 48.11  ? 178 GLY A CA  1 
ATOM 943  C C   . GLY A 1 257 ? 148.948 150.977 155.424 1.00 53.47  ? 178 GLY A C   1 
ATOM 944  O O   . GLY A 1 257 ? 149.911 150.376 154.940 1.00 58.33  ? 178 GLY A O   1 
ATOM 945  N N   . GLY A 1 258 ? 148.877 152.310 155.448 1.00 50.55  ? 179 GLY A N   1 
ATOM 946  C CA  . GLY A 1 258 ? 149.971 153.114 154.923 1.00 48.62  ? 179 GLY A CA  1 
ATOM 947  C C   . GLY A 1 258 ? 151.245 152.977 155.734 1.00 54.06  ? 179 GLY A C   1 
ATOM 948  O O   . GLY A 1 258 ? 152.345 152.941 155.177 1.00 57.19  ? 179 GLY A O   1 
ATOM 949  N N   . VAL A 1 259 ? 151.114 152.912 157.060 1.00 53.08  ? 180 VAL A N   1 
ATOM 950  C CA  . VAL A 1 259 ? 152.262 152.629 157.915 1.00 53.61  ? 180 VAL A CA  1 
ATOM 951  C C   . VAL A 1 259 ? 152.749 151.201 157.690 1.00 54.99  ? 180 VAL A C   1 
ATOM 952  O O   . VAL A 1 259 ? 153.956 150.932 157.710 1.00 63.31  ? 180 VAL A O   1 
ATOM 953  C CB  . VAL A 1 259 ? 151.894 152.898 159.388 1.00 50.09  ? 180 VAL A CB  1 
ATOM 954  C CG1 . VAL A 1 259 ? 152.986 152.430 160.335 1.00 60.02  ? 180 VAL A CG1 1 
ATOM 955  C CG2 . VAL A 1 259 ? 151.625 154.377 159.598 1.00 46.67  ? 180 VAL A CG2 1 
ATOM 956  N N   . ALA A 1 260 ? 151.819 150.273 157.437 1.00 51.85  ? 181 ALA A N   1 
ATOM 957  C CA  . ALA A 1 260 ? 152.170 148.866 157.254 1.00 58.85  ? 181 ALA A CA  1 
ATOM 958  C C   . ALA A 1 260 ? 153.065 148.661 156.039 1.00 65.56  ? 181 ALA A C   1 
ATOM 959  O O   . ALA A 1 260 ? 154.055 147.924 156.099 1.00 71.82  ? 181 ALA A O   1 
ATOM 960  C CB  . ALA A 1 260 ? 150.901 148.030 157.113 1.00 61.01  ? 181 ALA A CB  1 
ATOM 961  N N   . LEU A 1 261 ? 152.736 149.313 154.926 1.00 66.92  ? 182 LEU A N   1 
ATOM 962  C CA  . LEU A 1 261 ? 153.498 149.137 153.699 1.00 69.53  ? 182 LEU A CA  1 
ATOM 963  C C   . LEU A 1 261 ? 154.761 149.986 153.658 1.00 70.81  ? 182 LEU A C   1 
ATOM 964  O O   . LEU A 1 261 ? 155.533 149.868 152.701 1.00 72.50  ? 182 LEU A O   1 
ATOM 965  C CB  . LEU A 1 261 ? 152.616 149.455 152.490 1.00 69.70  ? 182 LEU A CB  1 
ATOM 966  C CG  . LEU A 1 261 ? 151.546 148.413 152.145 1.00 65.63  ? 182 LEU A CG  1 
ATOM 967  C CD1 . LEU A 1 261 ? 150.999 148.650 150.747 1.00 63.31  ? 182 LEU A CD1 1 
ATOM 968  C CD2 . LEU A 1 261 ? 152.084 146.995 152.279 1.00 64.52  ? 182 LEU A CD2 1 
ATOM 969  N N   . SER A 1 262 ? 154.987 150.835 154.659 1.00 71.35  ? 183 SER A N   1 
ATOM 970  C CA  . SER A 1 262 ? 156.194 151.645 154.738 1.00 73.35  ? 183 SER A CA  1 
ATOM 971  C C   . SER A 1 262 ? 157.194 151.135 155.768 1.00 73.96  ? 183 SER A C   1 
ATOM 972  O O   . SER A 1 262 ? 158.348 151.576 155.756 1.00 78.42  ? 183 SER A O   1 
ATOM 973  C CB  . SER A 1 262 ? 155.832 153.100 155.057 1.00 72.12  ? 183 SER A CB  1 
ATOM 974  O OG  . SER A 1 262 ? 154.954 153.630 154.079 1.00 69.51  ? 183 SER A OG  1 
ATOM 975  N N   . VAL A 1 263 ? 156.789 150.224 156.651 1.00 73.83  ? 184 VAL A N   1 
ATOM 976  C CA  . VAL A 1 263 ? 157.670 149.664 157.663 1.00 74.64  ? 184 VAL A CA  1 
ATOM 977  C C   . VAL A 1 263 ? 158.062 148.227 157.337 1.00 82.97  ? 184 VAL A C   1 
ATOM 978  O O   . VAL A 1 263 ? 159.230 147.856 157.476 1.00 90.61  ? 184 VAL A O   1 
ATOM 979  C CB  . VAL A 1 263 ? 157.027 149.754 159.065 1.00 69.58  ? 184 VAL A CB  1 
ATOM 980  C CG1 . VAL A 1 263 ? 157.945 149.162 160.124 1.00 80.10  ? 184 VAL A CG1 1 
ATOM 981  C CG2 . VAL A 1 263 ? 156.714 151.189 159.408 1.00 64.60  ? 184 VAL A CG2 1 
ATOM 982  N N   . LEU A 1 264 ? 157.101 147.409 156.899 1.00 78.69  ? 185 LEU A N   1 
ATOM 983  C CA  . LEU A 1 264 ? 157.371 145.992 156.650 1.00 80.40  ? 185 LEU A CA  1 
ATOM 984  C C   . LEU A 1 264 ? 158.411 145.738 155.554 1.00 87.16  ? 185 LEU A C   1 
ATOM 985  O O   . LEU A 1 264 ? 159.257 144.849 155.753 1.00 89.50  ? 185 LEU A O   1 
ATOM 986  C CB  . LEU A 1 264 ? 156.064 145.251 156.343 1.00 79.04  ? 185 LEU A CB  1 
ATOM 987  C CG  . LEU A 1 264 ? 156.110 143.718 156.433 1.00 81.43  ? 185 LEU A CG  1 
ATOM 988  C CD1 . LEU A 1 264 ? 157.067 143.221 157.516 1.00 83.43  ? 185 LEU A CD1 1 
ATOM 989  C CD2 . LEU A 1 264 ? 154.748 143.111 156.614 1.00 77.83  ? 185 LEU A CD2 1 
ATOM 990  N N   . PRO A 1 265 ? 158.403 146.415 154.387 1.00 86.43  ? 186 PRO A N   1 
ATOM 991  C CA  . PRO A 1 265 ? 159.534 146.221 153.457 1.00 85.67  ? 186 PRO A CA  1 
ATOM 992  C C   . PRO A 1 265 ? 160.875 146.623 154.041 1.00 91.88  ? 186 PRO A C   1 
ATOM 993  O O   . PRO A 1 265 ? 161.902 146.033 153.682 1.00 97.57  ? 186 PRO A O   1 
ATOM 994  C CB  . PRO A 1 265 ? 159.158 147.094 152.252 1.00 83.15  ? 186 PRO A CB  1 
ATOM 995  C CG  . PRO A 1 265 ? 157.697 147.189 152.305 1.00 84.42  ? 186 PRO A CG  1 
ATOM 996  C CD  . PRO A 1 265 ? 157.369 147.264 153.758 1.00 82.72  ? 186 PRO A CD  1 
ATOM 997  N N   . MET A 1 266 ? 160.896 147.611 154.934 1.00 90.88  ? 187 MET A N   1 
ATOM 998  C CA  . MET A 1 266 ? 162.117 147.920 155.662 1.00 91.71  ? 187 MET A CA  1 
ATOM 999  C C   . MET A 1 266 ? 162.401 146.904 156.760 1.00 93.90  ? 187 MET A C   1 
ATOM 1000 O O   . MET A 1 266 ? 163.568 146.669 157.086 1.00 98.08  ? 187 MET A O   1 
ATOM 1001 C CB  . MET A 1 266 ? 162.034 149.327 156.255 1.00 91.51  ? 187 MET A CB  1 
ATOM 1002 C CG  . MET A 1 266 ? 161.584 150.388 155.264 1.00 93.10  ? 187 MET A CG  1 
ATOM 1003 S SD  . MET A 1 266 ? 162.186 150.065 153.595 1.00 101.24 ? 187 MET A SD  1 
ATOM 1004 C CE  . MET A 1 266 ? 161.438 151.419 152.694 1.00 99.54  ? 187 MET A CE  1 
ATOM 1005 N N   . TYR A 1 267 ? 161.363 146.297 157.342 1.00 92.86  ? 188 TYR A N   1 
ATOM 1006 C CA  . TYR A 1 267 ? 161.574 145.401 158.477 1.00 96.19  ? 188 TYR A CA  1 
ATOM 1007 C C   . TYR A 1 267 ? 162.246 144.098 158.057 1.00 97.01  ? 188 TYR A C   1 
ATOM 1008 O O   . TYR A 1 267 ? 163.215 143.663 158.688 1.00 101.36 ? 188 TYR A O   1 
ATOM 1009 C CB  . TYR A 1 267 ? 160.250 145.113 159.185 1.00 96.61  ? 188 TYR A CB  1 
ATOM 1010 C CG  . TYR A 1 267 ? 160.420 144.260 160.422 1.00 100.23 ? 188 TYR A CG  1 
ATOM 1011 C CD1 . TYR A 1 267 ? 161.235 144.677 161.465 1.00 97.38  ? 188 TYR A CD1 1 
ATOM 1012 C CD2 . TYR A 1 267 ? 159.775 143.036 160.542 1.00 102.10 ? 188 TYR A CD2 1 
ATOM 1013 C CE1 . TYR A 1 267 ? 161.400 143.903 162.597 1.00 100.35 ? 188 TYR A CE1 1 
ATOM 1014 C CE2 . TYR A 1 267 ? 159.934 142.253 161.672 1.00 102.46 ? 188 TYR A CE2 1 
ATOM 1015 C CZ  . TYR A 1 267 ? 160.748 142.693 162.695 1.00 103.39 ? 188 TYR A CZ  1 
ATOM 1016 O OH  . TYR A 1 267 ? 160.911 141.921 163.822 1.00 105.91 ? 188 TYR A OH  1 
ATOM 1017 N N   . LEU A 1 268 ? 161.743 143.456 156.997 1.00 93.69  ? 189 LEU A N   1 
ATOM 1018 C CA  . LEU A 1 268 ? 162.296 142.165 156.592 1.00 98.46  ? 189 LEU A CA  1 
ATOM 1019 C C   . LEU A 1 268 ? 163.708 142.287 156.039 1.00 103.77 ? 189 LEU A C   1 
ATOM 1020 O O   . LEU A 1 268 ? 164.484 141.328 156.122 1.00 106.54 ? 189 LEU A O   1 
ATOM 1021 C CB  . LEU A 1 268 ? 161.397 141.489 155.557 1.00 100.65 ? 189 LEU A CB  1 
ATOM 1022 C CG  . LEU A 1 268 ? 159.883 141.583 155.697 1.00 97.46  ? 189 LEU A CG  1 
ATOM 1023 C CD1 . LEU A 1 268 ? 159.227 141.372 154.351 1.00 91.45  ? 189 LEU A CD1 1 
ATOM 1024 C CD2 . LEU A 1 268 ? 159.413 140.528 156.684 1.00 98.67  ? 189 LEU A CD2 1 
ATOM 1025 N N   . SER A 1 269 ? 164.054 143.438 155.462 1.00 104.80 ? 190 SER A N   1 
ATOM 1026 C CA  . SER A 1 269 ? 165.367 143.585 154.844 1.00 106.16 ? 190 SER A CA  1 
ATOM 1027 C C   . SER A 1 269 ? 166.486 143.592 155.882 1.00 108.69 ? 190 SER A C   1 
ATOM 1028 O O   . SER A 1 269 ? 167.546 142.998 155.656 1.00 108.77 ? 190 SER A O   1 
ATOM 1029 C CB  . SER A 1 269 ? 165.400 144.851 153.986 1.00 104.37 ? 190 SER A CB  1 
ATOM 1030 O OG  . SER A 1 269 ? 165.472 146.016 154.783 1.00 105.01 ? 190 SER A OG  1 
ATOM 1031 N N   . GLU A 1 270 ? 166.271 144.244 157.029 1.00 108.16 ? 191 GLU A N   1 
ATOM 1032 C CA  . GLU A 1 270 ? 167.335 144.323 158.028 1.00 110.12 ? 191 GLU A CA  1 
ATOM 1033 C C   . GLU A 1 270 ? 167.517 143.013 158.787 1.00 112.38 ? 191 GLU A C   1 
ATOM 1034 O O   . GLU A 1 270 ? 168.641 142.685 159.184 1.00 116.80 ? 191 GLU A O   1 
ATOM 1035 C CB  . GLU A 1 270 ? 167.083 145.466 159.021 1.00 107.05 ? 191 GLU A CB  1 
ATOM 1036 C CG  . GLU A 1 270 ? 166.457 146.798 158.525 1.00 105.05 ? 191 GLU A CG  1 
ATOM 1037 C CD  . GLU A 1 270 ? 166.902 147.298 157.143 1.00 110.78 ? 191 GLU A CD  1 
ATOM 1038 O OE1 . GLU A 1 270 ? 168.055 147.072 156.719 1.00 114.53 ? 191 GLU A OE1 1 
ATOM 1039 O OE2 . GLU A 1 270 ? 166.074 147.942 156.468 1.00 108.30 ? 191 GLU A OE2 1 
ATOM 1040 N N   . ILE A 1 271 ? 166.438 142.253 159.004 1.00 109.48 ? 192 ILE A N   1 
ATOM 1041 C CA  . ILE A 1 271 ? 166.521 141.033 159.802 1.00 111.60 ? 192 ILE A CA  1 
ATOM 1042 C C   . ILE A 1 271 ? 166.881 139.802 158.980 1.00 113.20 ? 192 ILE A C   1 
ATOM 1043 O O   . ILE A 1 271 ? 167.028 138.710 159.548 1.00 114.81 ? 192 ILE A O   1 
ATOM 1044 C CB  . ILE A 1 271 ? 165.203 140.810 160.576 1.00 110.51 ? 192 ILE A CB  1 
ATOM 1045 C CG1 . ILE A 1 271 ? 164.155 140.115 159.696 1.00 108.69 ? 192 ILE A CG1 1 
ATOM 1046 C CG2 . ILE A 1 271 ? 164.694 142.123 161.157 1.00 110.15 ? 192 ILE A CG2 1 
ATOM 1047 C CD1 . ILE A 1 271 ? 162.759 140.096 160.289 1.00 106.65 ? 192 ILE A CD1 1 
ATOM 1048 N N   . SER A 1 272 ? 167.073 139.943 157.671 1.00 113.77 ? 193 SER A N   1 
ATOM 1049 C CA  . SER A 1 272 ? 167.353 138.794 156.827 1.00 114.80 ? 193 SER A CA  1 
ATOM 1050 C C   . SER A 1 272 ? 168.661 138.988 156.067 1.00 115.20 ? 193 SER A C   1 
ATOM 1051 O O   . SER A 1 272 ? 169.062 140.127 155.803 1.00 115.26 ? 193 SER A O   1 
ATOM 1052 C CB  . SER A 1 272 ? 166.205 138.563 155.836 1.00 113.37 ? 193 SER A CB  1 
ATOM 1053 O OG  . SER A 1 272 ? 164.984 138.389 156.531 1.00 109.68 ? 193 SER A OG  1 
ATOM 1054 N N   . PRO A 1 273 ? 169.356 137.903 155.719 1.00 115.81 ? 194 PRO A N   1 
ATOM 1055 C CA  . PRO A 1 273 ? 170.614 138.038 154.972 1.00 118.90 ? 194 PRO A CA  1 
ATOM 1056 C C   . PRO A 1 273 ? 170.393 138.572 153.564 1.00 117.74 ? 194 PRO A C   1 
ATOM 1057 O O   . PRO A 1 273 ? 169.276 138.604 153.043 1.00 115.15 ? 194 PRO A O   1 
ATOM 1058 C CB  . PRO A 1 273 ? 171.179 136.613 154.933 1.00 118.31 ? 194 PRO A CB  1 
ATOM 1059 C CG  . PRO A 1 273 ? 170.398 135.822 155.898 1.00 117.62 ? 194 PRO A CG  1 
ATOM 1060 C CD  . PRO A 1 273 ? 169.120 136.525 156.186 1.00 114.12 ? 194 PRO A CD  1 
ATOM 1061 N N   . LYS A 1 274 ? 171.501 138.998 152.949 1.00 118.56 ? 195 LYS A N   1 
ATOM 1062 C CA  . LYS A 1 274 ? 171.445 139.704 151.673 1.00 116.40 ? 195 LYS A CA  1 
ATOM 1063 C C   . LYS A 1 274 ? 171.020 138.814 150.510 1.00 117.23 ? 195 LYS A C   1 
ATOM 1064 O O   . LYS A 1 274 ? 170.616 139.338 149.467 1.00 115.37 ? 195 LYS A O   1 
ATOM 1065 C CB  . LYS A 1 274 ? 172.803 140.342 151.368 1.00 115.99 ? 195 LYS A CB  1 
ATOM 1066 C CG  . LYS A 1 274 ? 173.874 139.359 150.926 1.00 121.69 ? 195 LYS A CG  1 
ATOM 1067 C CD  . LYS A 1 274 ? 175.252 139.797 151.391 1.00 124.35 ? 195 LYS A CD  1 
ATOM 1068 C CE  . LYS A 1 274 ? 176.232 138.637 151.369 1.00 123.09 ? 195 LYS A CE  1 
ATOM 1069 N NZ  . LYS A 1 274 ? 175.880 137.601 152.378 1.00 118.40 ? 195 LYS A NZ  1 
ATOM 1070 N N   . GLU A 1 275 ? 171.098 137.494 150.656 1.00 118.62 ? 196 GLU A N   1 
ATOM 1071 C CA  . GLU A 1 275 ? 170.728 136.583 149.581 1.00 118.80 ? 196 GLU A CA  1 
ATOM 1072 C C   . GLU A 1 275 ? 169.261 136.169 149.623 1.00 117.79 ? 196 GLU A C   1 
ATOM 1073 O O   . GLU A 1 275 ? 168.805 135.475 148.709 1.00 117.74 ? 196 GLU A O   1 
ATOM 1074 C CB  . GLU A 1 275 ? 171.624 135.334 149.603 1.00 118.44 ? 196 GLU A CB  1 
ATOM 1075 C CG  . GLU A 1 275 ? 171.760 134.640 150.956 1.00 116.85 ? 196 GLU A CG  1 
ATOM 1076 C CD  . GLU A 1 275 ? 172.881 135.205 151.812 1.00 118.36 ? 196 GLU A CD  1 
ATOM 1077 O OE1 . GLU A 1 275 ? 172.849 136.414 152.123 1.00 117.59 ? 196 GLU A OE1 1 
ATOM 1078 O OE2 . GLU A 1 275 ? 173.793 134.436 152.181 1.00 122.58 ? 196 GLU A OE2 1 
ATOM 1079 N N   . ILE A 1 276 ? 168.516 136.566 150.655 1.00 114.37 ? 197 ILE A N   1 
ATOM 1080 C CA  . ILE A 1 276 ? 167.081 136.301 150.748 1.00 110.28 ? 197 ILE A CA  1 
ATOM 1081 C C   . ILE A 1 276 ? 166.257 137.573 150.579 1.00 108.03 ? 197 ILE A C   1 
ATOM 1082 O O   . ILE A 1 276 ? 165.019 137.514 150.637 1.00 107.20 ? 197 ILE A O   1 
ATOM 1083 C CB  . ILE A 1 276 ? 166.706 135.590 152.072 1.00 109.85 ? 197 ILE A CB  1 
ATOM 1084 C CG1 . ILE A 1 276 ? 167.804 134.672 152.643 1.00 114.47 ? 197 ILE A CG1 1 
ATOM 1085 C CG2 . ILE A 1 276 ? 165.497 134.674 151.881 1.00 108.19 ? 197 ILE A CG2 1 
ATOM 1086 C CD1 . ILE A 1 276 ? 168.335 133.562 151.714 1.00 114.55 ? 197 ILE A CD1 1 
ATOM 1087 N N   . ARG A 1 277 ? 166.904 138.723 150.360 1.00 107.15 ? 198 ARG A N   1 
ATOM 1088 C CA  . ARG A 1 277 ? 166.180 139.989 150.257 1.00 103.41 ? 198 ARG A CA  1 
ATOM 1089 C C   . ARG A 1 277 ? 165.275 140.028 149.032 1.00 102.58 ? 198 ARG A C   1 
ATOM 1090 O O   . ARG A 1 277 ? 164.159 140.557 149.095 1.00 103.42 ? 198 ARG A O   1 
ATOM 1091 C CB  . ARG A 1 277 ? 167.166 141.156 150.220 1.00 104.82 ? 198 ARG A CB  1 
ATOM 1092 C CG  . ARG A 1 277 ? 168.115 141.203 151.396 1.00 109.11 ? 198 ARG A CG  1 
ATOM 1093 C CD  . ARG A 1 277 ? 167.811 142.366 152.320 1.00 109.00 ? 198 ARG A CD  1 
ATOM 1094 N NE  . ARG A 1 277 ? 168.741 142.413 153.441 1.00 109.33 ? 198 ARG A NE  1 
ATOM 1095 C CZ  . ARG A 1 277 ? 169.790 143.221 153.511 1.00 108.83 ? 198 ARG A CZ  1 
ATOM 1096 N NH1 . ARG A 1 277 ? 170.072 144.073 152.540 1.00 108.65 ? 198 ARG A NH1 1 
ATOM 1097 N NH2 . ARG A 1 277 ? 170.576 143.172 154.583 1.00 107.97 ? 198 ARG A NH2 1 
ATOM 1098 N N   . GLY A 1 278 ? 165.746 139.489 147.905 1.00 102.98 ? 199 GLY A N   1 
ATOM 1099 C CA  . GLY A 1 278 ? 164.949 139.518 146.688 1.00 101.44 ? 199 GLY A CA  1 
ATOM 1100 C C   . GLY A 1 278 ? 163.689 138.676 146.779 1.00 99.98  ? 199 GLY A C   1 
ATOM 1101 O O   . GLY A 1 278 ? 162.627 139.081 146.299 1.00 98.86  ? 199 GLY A O   1 
ATOM 1102 N N   . SER A 1 279 ? 163.788 137.498 147.397 1.00 99.83  ? 200 SER A N   1 
ATOM 1103 C CA  . SER A 1 279 ? 162.622 136.636 147.539 1.00 100.64 ? 200 SER A CA  1 
ATOM 1104 C C   . SER A 1 279 ? 161.641 137.151 148.584 1.00 95.81  ? 200 SER A C   1 
ATOM 1105 O O   . SER A 1 279 ? 160.461 136.788 148.536 1.00 89.91  ? 200 SER A O   1 
ATOM 1106 C CB  . SER A 1 279 ? 163.058 135.214 147.895 1.00 102.58 ? 200 SER A CB  1 
ATOM 1107 O OG  . SER A 1 279 ? 164.119 135.226 148.834 1.00 102.14 ? 200 SER A OG  1 
ATOM 1108 N N   . LEU A 1 280 ? 162.095 137.980 149.525 1.00 95.29  ? 201 LEU A N   1 
ATOM 1109 C CA  . LEU A 1 280 ? 161.195 138.517 150.537 1.00 91.75  ? 201 LEU A CA  1 
ATOM 1110 C C   . LEU A 1 280 ? 160.331 139.655 150.014 1.00 88.92  ? 201 LEU A C   1 
ATOM 1111 O O   . LEU A 1 280 ? 159.329 139.994 150.653 1.00 87.25  ? 201 LEU A O   1 
ATOM 1112 C CB  . LEU A 1 280 ? 161.986 138.982 151.760 1.00 91.07  ? 201 LEU A CB  1 
ATOM 1113 C CG  . LEU A 1 280 ? 162.428 137.866 152.710 1.00 93.09  ? 201 LEU A CG  1 
ATOM 1114 C CD1 . LEU A 1 280 ? 162.903 138.452 154.020 1.00 95.43  ? 201 LEU A CD1 1 
ATOM 1115 C CD2 . LEU A 1 280 ? 161.308 136.862 152.949 1.00 86.49  ? 201 LEU A CD2 1 
ATOM 1116 N N   . GLY A 1 281 ? 160.700 140.259 148.881 1.00 87.61  ? 202 GLY A N   1 
ATOM 1117 C CA  . GLY A 1 281 ? 159.794 141.182 148.220 1.00 84.85  ? 202 GLY A CA  1 
ATOM 1118 C C   . GLY A 1 281 ? 158.536 140.499 147.726 1.00 81.54  ? 202 GLY A C   1 
ATOM 1119 O O   . GLY A 1 281 ? 157.471 141.119 147.659 1.00 73.88  ? 202 GLY A O   1 
ATOM 1120 N N   . GLN A 1 282 ? 158.646 139.220 147.358 1.00 83.64  ? 203 GLN A N   1 
ATOM 1121 C CA  . GLN A 1 282 ? 157.467 138.418 147.052 1.00 78.75  ? 203 GLN A CA  1 
ATOM 1122 C C   . GLN A 1 282 ? 156.589 138.223 148.281 1.00 75.13  ? 203 GLN A C   1 
ATOM 1123 O O   . GLN A 1 282 ? 155.360 138.297 148.183 1.00 72.87  ? 203 GLN A O   1 
ATOM 1124 C CB  . GLN A 1 282 ? 157.889 137.061 146.491 1.00 79.24  ? 203 GLN A CB  1 
ATOM 1125 C CG  . GLN A 1 282 ? 157.198 136.661 145.204 1.00 80.90  ? 203 GLN A CG  1 
ATOM 1126 C CD  . GLN A 1 282 ? 157.681 135.321 144.693 1.00 81.44  ? 203 GLN A CD  1 
ATOM 1127 O OE1 . GLN A 1 282 ? 158.112 134.467 145.468 1.00 82.74  ? 203 GLN A OE1 1 
ATOM 1128 N NE2 . GLN A 1 282 ? 157.596 135.121 143.387 1.00 77.97  ? 203 GLN A NE2 1 
ATOM 1129 N N   . VAL A 1 283 ? 157.208 137.981 149.443 1.00 75.16  ? 204 VAL A N   1 
ATOM 1130 C CA  . VAL A 1 283 ? 156.477 137.579 150.646 1.00 74.74  ? 204 VAL A CA  1 
ATOM 1131 C C   . VAL A 1 283 ? 155.539 138.689 151.113 1.00 72.16  ? 204 VAL A C   1 
ATOM 1132 O O   . VAL A 1 283 ? 154.387 138.431 151.488 1.00 69.62  ? 204 VAL A O   1 
ATOM 1133 C CB  . VAL A 1 283 ? 157.474 137.155 151.745 1.00 79.56  ? 204 VAL A CB  1 
ATOM 1134 C CG1 . VAL A 1 283 ? 156.905 137.366 153.145 1.00 78.00  ? 204 VAL A CG1 1 
ATOM 1135 C CG2 . VAL A 1 283 ? 157.881 135.702 151.553 1.00 81.89  ? 204 VAL A CG2 1 
ATOM 1136 N N   . THR A 1 284 ? 156.011 139.939 151.086 1.00 72.62  ? 205 THR A N   1 
ATOM 1137 C CA  . THR A 1 284 ? 155.133 141.071 151.366 1.00 67.50  ? 205 THR A CA  1 
ATOM 1138 C C   . THR A 1 284 ? 154.015 141.159 150.333 1.00 63.36  ? 205 THR A C   1 
ATOM 1139 O O   . THR A 1 284 ? 152.847 141.366 150.684 1.00 61.09  ? 205 THR A O   1 
ATOM 1140 C CB  . THR A 1 284 ? 155.955 142.365 151.408 1.00 71.19  ? 205 THR A CB  1 
ATOM 1141 O OG1 . THR A 1 284 ? 156.599 142.478 152.682 1.00 81.81  ? 205 THR A OG1 1 
ATOM 1142 C CG2 . THR A 1 284 ? 155.083 143.596 151.189 1.00 67.76  ? 205 THR A CG2 1 
ATOM 1143 N N   . ALA A 1 285 ? 154.349 140.955 149.057 1.00 67.76  ? 206 ALA A N   1 
ATOM 1144 C CA  . ALA A 1 285 ? 153.332 140.948 148.013 1.00 64.62  ? 206 ALA A CA  1 
ATOM 1145 C C   . ALA A 1 285 ? 152.421 139.730 148.111 1.00 61.86  ? 206 ALA A C   1 
ATOM 1146 O O   . ALA A 1 285 ? 151.243 139.822 147.755 1.00 60.50  ? 206 ALA A O   1 
ATOM 1147 C CB  . ALA A 1 285 ? 153.991 141.003 146.636 1.00 69.35  ? 206 ALA A CB  1 
ATOM 1148 N N   . ILE A 1 286 ? 152.943 138.593 148.585 1.00 64.71  ? 207 ILE A N   1 
ATOM 1149 C CA  . ILE A 1 286 ? 152.156 137.361 148.651 1.00 61.35  ? 207 ILE A CA  1 
ATOM 1150 C C   . ILE A 1 286 ? 151.006 137.507 149.642 1.00 61.61  ? 207 ILE A C   1 
ATOM 1151 O O   . ILE A 1 286 ? 149.863 137.138 149.349 1.00 58.59  ? 207 ILE A O   1 
ATOM 1152 C CB  . ILE A 1 286 ? 153.064 136.164 149.000 1.00 60.06  ? 207 ILE A CB  1 
ATOM 1153 C CG1 . ILE A 1 286 ? 153.641 135.557 147.723 1.00 65.22  ? 207 ILE A CG1 1 
ATOM 1154 C CG2 . ILE A 1 286 ? 152.332 135.094 149.809 1.00 59.01  ? 207 ILE A CG2 1 
ATOM 1155 C CD1 . ILE A 1 286 ? 152.653 134.723 146.958 1.00 67.78  ? 207 ILE A CD1 1 
ATOM 1156 N N   . PHE A 1 287 ? 151.285 138.066 150.820 1.00 60.95  ? 208 PHE A N   1 
ATOM 1157 C CA  . PHE A 1 287 ? 150.258 138.143 151.849 1.00 57.44  ? 208 PHE A CA  1 
ATOM 1158 C C   . PHE A 1 287 ? 149.223 139.218 151.551 1.00 54.95  ? 208 PHE A C   1 
ATOM 1159 O O   . PHE A 1 287 ? 148.123 139.171 152.108 1.00 58.31  ? 208 PHE A O   1 
ATOM 1160 C CB  . PHE A 1 287 ? 150.908 138.371 153.211 1.00 62.86  ? 208 PHE A CB  1 
ATOM 1161 C CG  . PHE A 1 287 ? 150.944 137.141 154.067 1.00 69.24  ? 208 PHE A CG  1 
ATOM 1162 C CD1 . PHE A 1 287 ? 149.829 136.752 154.791 1.00 66.33  ? 208 PHE A CD1 1 
ATOM 1163 C CD2 . PHE A 1 287 ? 152.084 136.355 154.126 1.00 73.68  ? 208 PHE A CD2 1 
ATOM 1164 C CE1 . PHE A 1 287 ? 149.855 135.613 155.573 1.00 71.33  ? 208 PHE A CE1 1 
ATOM 1165 C CE2 . PHE A 1 287 ? 152.117 135.216 154.906 1.00 83.17  ? 208 PHE A CE2 1 
ATOM 1166 C CZ  . PHE A 1 287 ? 151.000 134.844 155.631 1.00 83.28  ? 208 PHE A CZ  1 
ATOM 1167 N N   . ILE A 1 288 ? 149.551 140.181 150.689 1.00 51.50  ? 209 ILE A N   1 
ATOM 1168 C CA  . ILE A 1 288 ? 148.537 141.099 150.184 1.00 48.76  ? 209 ILE A CA  1 
ATOM 1169 C C   . ILE A 1 288 ? 147.559 140.352 149.284 1.00 51.26  ? 209 ILE A C   1 
ATOM 1170 O O   . ILE A 1 288 ? 146.348 140.605 149.310 1.00 52.21  ? 209 ILE A O   1 
ATOM 1171 C CB  . ILE A 1 288 ? 149.212 142.279 149.461 1.00 46.28  ? 209 ILE A CB  1 
ATOM 1172 C CG1 . ILE A 1 288 ? 150.042 143.096 150.455 1.00 49.24  ? 209 ILE A CG1 1 
ATOM 1173 C CG2 . ILE A 1 288 ? 148.183 143.169 148.770 1.00 47.24  ? 209 ILE A CG2 1 
ATOM 1174 C CD1 . ILE A 1 288 ? 150.540 144.423 149.919 1.00 52.83  ? 209 ILE A CD1 1 
ATOM 1175 N N   . CYS A 1 289 ? 148.069 139.404 148.491 1.00 52.94  ? 210 CYS A N   1 
ATOM 1176 C CA  . CYS A 1 289 ? 147.213 138.599 147.623 1.00 53.00  ? 210 CYS A CA  1 
ATOM 1177 C C   . CYS A 1 289 ? 146.265 137.722 148.432 1.00 50.87  ? 210 CYS A C   1 
ATOM 1178 O O   . CYS A 1 289 ? 145.088 137.579 148.082 1.00 48.34  ? 210 CYS A O   1 
ATOM 1179 C CB  . CYS A 1 289 ? 148.070 137.731 146.702 1.00 60.98  ? 210 CYS A CB  1 
ATOM 1180 S SG  . CYS A 1 289 ? 149.235 138.631 145.659 1.00 80.78  ? 210 CYS A SG  1 
ATOM 1181 N N   . ILE A 1 290 ? 146.768 137.117 149.511 1.00 50.48  ? 211 ILE A N   1 
ATOM 1182 C CA  . ILE A 1 290 ? 145.944 136.247 150.345 1.00 46.16  ? 211 ILE A CA  1 
ATOM 1183 C C   . ILE A 1 290 ? 144.874 137.058 151.070 1.00 44.22  ? 211 ILE A C   1 
ATOM 1184 O O   . ILE A 1 290 ? 143.745 136.589 151.266 1.00 45.80  ? 211 ILE A O   1 
ATOM 1185 C CB  . ILE A 1 290 ? 146.841 135.451 151.314 1.00 44.73  ? 211 ILE A CB  1 
ATOM 1186 C CG1 . ILE A 1 290 ? 147.650 134.409 150.545 1.00 44.69  ? 211 ILE A CG1 1 
ATOM 1187 C CG2 . ILE A 1 290 ? 146.034 134.719 152.366 1.00 44.71  ? 211 ILE A CG2 1 
ATOM 1188 C CD1 . ILE A 1 290 ? 149.001 134.131 151.148 1.00 54.91  ? 211 ILE A CD1 1 
ATOM 1189 N N   . GLY A 1 291 ? 145.200 138.295 151.456 1.00 42.42  ? 212 GLY A N   1 
ATOM 1190 C CA  . GLY A 1 291 ? 144.208 139.159 152.079 1.00 39.58  ? 212 GLY A CA  1 
ATOM 1191 C C   . GLY A 1 291 ? 143.039 139.475 151.164 1.00 41.31  ? 212 GLY A C   1 
ATOM 1192 O O   . GLY A 1 291 ? 141.885 139.485 151.598 1.00 39.95  ? 212 GLY A O   1 
ATOM 1193 N N   . VAL A 1 292 ? 143.321 139.726 149.882 1.00 43.77  ? 213 VAL A N   1 
ATOM 1194 C CA  . VAL A 1 292 ? 142.256 139.908 148.898 1.00 37.90  ? 213 VAL A CA  1 
ATOM 1195 C C   . VAL A 1 292 ? 141.465 138.615 148.735 1.00 38.77  ? 213 VAL A C   1 
ATOM 1196 O O   . VAL A 1 292 ? 140.236 138.632 148.597 1.00 39.89  ? 213 VAL A O   1 
ATOM 1197 C CB  . VAL A 1 292 ? 142.848 140.390 147.559 1.00 38.76  ? 213 VAL A CB  1 
ATOM 1198 C CG1 . VAL A 1 292 ? 141.770 140.520 146.497 1.00 38.58  ? 213 VAL A CG1 1 
ATOM 1199 C CG2 . VAL A 1 292 ? 143.575 141.710 147.740 1.00 43.91  ? 213 VAL A CG2 1 
ATOM 1200 N N   . PHE A 1 293 ? 142.162 137.475 148.760 1.00 40.05  ? 214 PHE A N   1 
ATOM 1201 C CA  . PHE A 1 293 ? 141.496 136.176 148.744 1.00 37.31  ? 214 PHE A CA  1 
ATOM 1202 C C   . PHE A 1 293 ? 140.624 135.982 149.980 1.00 38.35  ? 214 PHE A C   1 
ATOM 1203 O O   . PHE A 1 293 ? 139.449 135.619 149.869 1.00 40.75  ? 214 PHE A O   1 
ATOM 1204 C CB  . PHE A 1 293 ? 142.540 135.064 148.644 1.00 38.51  ? 214 PHE A CB  1 
ATOM 1205 C CG  . PHE A 1 293 ? 141.969 133.713 148.328 1.00 41.35  ? 214 PHE A CG  1 
ATOM 1206 C CD1 . PHE A 1 293 ? 140.830 133.583 147.552 1.00 43.50  ? 214 PHE A CD1 1 
ATOM 1207 C CD2 . PHE A 1 293 ? 142.571 132.568 148.823 1.00 40.39  ? 214 PHE A CD2 1 
ATOM 1208 C CE1 . PHE A 1 293 ? 140.311 132.334 147.267 1.00 40.42  ? 214 PHE A CE1 1 
ATOM 1209 C CE2 . PHE A 1 293 ? 142.054 131.319 148.544 1.00 41.93  ? 214 PHE A CE2 1 
ATOM 1210 C CZ  . PHE A 1 293 ? 140.921 131.203 147.765 1.00 41.69  ? 214 PHE A CZ  1 
ATOM 1211 N N   . THR A 1 294 ? 141.189 136.225 151.168 1.00 40.96  ? 215 THR A N   1 
ATOM 1212 C CA  . THR A 1 294 ? 140.463 135.996 152.417 1.00 40.11  ? 215 THR A CA  1 
ATOM 1213 C C   . THR A 1 294 ? 139.291 136.961 152.571 1.00 36.86  ? 215 THR A C   1 
ATOM 1214 O O   . THR A 1 294 ? 138.197 136.555 152.982 1.00 37.71  ? 215 THR A O   1 
ATOM 1215 C CB  . THR A 1 294 ? 141.431 136.108 153.598 1.00 42.45  ? 215 THR A CB  1 
ATOM 1216 O OG1 . THR A 1 294 ? 142.241 134.928 153.662 1.00 46.58  ? 215 THR A OG1 1 
ATOM 1217 C CG2 . THR A 1 294 ? 140.698 136.271 154.923 1.00 37.37  ? 215 THR A CG2 1 
ATOM 1218 N N   . GLY A 1 295 ? 139.495 138.234 152.222 1.00 33.94  ? 216 GLY A N   1 
ATOM 1219 C CA  . GLY A 1 295 ? 138.413 139.203 152.308 1.00 32.99  ? 216 GLY A CA  1 
ATOM 1220 C C   . GLY A 1 295 ? 137.260 138.882 151.377 1.00 35.69  ? 216 GLY A C   1 
ATOM 1221 O O   . GLY A 1 295 ? 136.096 139.124 151.707 1.00 37.18  ? 216 GLY A O   1 
ATOM 1222 N N   . GLN A 1 296 ? 137.566 138.338 150.199 1.00 37.09  ? 217 GLN A N   1 
ATOM 1223 C CA  . GLN A 1 296 ? 136.523 137.862 149.300 1.00 32.73  ? 217 GLN A CA  1 
ATOM 1224 C C   . GLN A 1 296 ? 135.954 136.520 149.742 1.00 33.72  ? 217 GLN A C   1 
ATOM 1225 O O   . GLN A 1 296 ? 134.764 136.262 149.533 1.00 36.81  ? 217 GLN A O   1 
ATOM 1226 C CB  . GLN A 1 296 ? 137.066 137.761 147.876 1.00 31.72  ? 217 GLN A CB  1 
ATOM 1227 C CG  . GLN A 1 296 ? 137.060 139.081 147.132 1.00 34.08  ? 217 GLN A CG  1 
ATOM 1228 C CD  . GLN A 1 296 ? 137.727 138.985 145.780 1.00 38.82  ? 217 GLN A CD  1 
ATOM 1229 O OE1 . GLN A 1 296 ? 138.485 138.055 145.516 1.00 41.88  ? 217 GLN A OE1 1 
ATOM 1230 N NE2 . GLN A 1 296 ? 137.452 139.953 144.915 1.00 38.18  ? 217 GLN A NE2 1 
ATOM 1231 N N   . LEU A 1 297 ? 136.787 135.654 150.329 1.00 34.20  ? 218 LEU A N   1 
ATOM 1232 C CA  . LEU A 1 297 ? 136.297 134.377 150.843 1.00 35.08  ? 218 LEU A CA  1 
ATOM 1233 C C   . LEU A 1 297 ? 135.359 134.580 152.025 1.00 37.88  ? 218 LEU A C   1 
ATOM 1234 O O   . LEU A 1 297 ? 134.334 133.899 152.137 1.00 39.88  ? 218 LEU A O   1 
ATOM 1235 C CB  . LEU A 1 297 ? 137.473 133.481 151.232 1.00 37.67  ? 218 LEU A CB  1 
ATOM 1236 C CG  . LEU A 1 297 ? 137.213 132.303 152.169 1.00 44.34  ? 218 LEU A CG  1 
ATOM 1237 C CD1 . LEU A 1 297 ? 136.470 131.201 151.437 1.00 46.15  ? 218 LEU A CD1 1 
ATOM 1238 C CD2 . LEU A 1 297 ? 138.520 131.782 152.741 1.00 41.26  ? 218 LEU A CD2 1 
ATOM 1239 N N   . LEU A 1 298 ? 135.681 135.521 152.912 1.00 38.13  ? 219 LEU A N   1 
ATOM 1240 C CA  . LEU A 1 298 ? 134.801 135.809 154.037 1.00 38.48  ? 219 LEU A CA  1 
ATOM 1241 C C   . LEU A 1 298 ? 133.532 136.543 153.622 1.00 40.65  ? 219 LEU A C   1 
ATOM 1242 O O   . LEU A 1 298 ? 132.624 136.684 154.445 1.00 42.40  ? 219 LEU A O   1 
ATOM 1243 C CB  . LEU A 1 298 ? 135.549 136.623 155.094 1.00 35.88  ? 219 LEU A CB  1 
ATOM 1244 C CG  . LEU A 1 298 ? 136.583 135.871 155.936 1.00 37.34  ? 219 LEU A CG  1 
ATOM 1245 C CD1 . LEU A 1 298 ? 137.003 136.699 157.140 1.00 34.81  ? 219 LEU A CD1 1 
ATOM 1246 C CD2 . LEU A 1 298 ? 136.049 134.518 156.378 1.00 40.44  ? 219 LEU A CD2 1 
ATOM 1247 N N   . GLY A 1 299 ? 133.443 137.011 152.383 1.00 39.55  ? 220 GLY A N   1 
ATOM 1248 C CA  . GLY A 1 299 ? 132.270 137.701 151.899 1.00 37.87  ? 220 GLY A CA  1 
ATOM 1249 C C   . GLY A 1 299 ? 131.196 136.820 151.304 1.00 40.48  ? 220 GLY A C   1 
ATOM 1250 O O   . GLY A 1 299 ? 130.215 137.347 150.770 1.00 45.31  ? 220 GLY A O   1 
ATOM 1251 N N   . LEU A 1 300 ? 131.351 135.498 151.364 1.00 40.07  ? 221 LEU A N   1 
ATOM 1252 C CA  . LEU A 1 300 ? 130.329 134.607 150.842 1.00 42.31  ? 221 LEU A CA  1 
ATOM 1253 C C   . LEU A 1 300 ? 129.084 134.653 151.726 1.00 46.69  ? 221 LEU A C   1 
ATOM 1254 O O   . LEU A 1 300 ? 129.171 134.970 152.915 1.00 50.21  ? 221 LEU A O   1 
ATOM 1255 C CB  . LEU A 1 300 ? 130.844 133.171 150.760 1.00 41.09  ? 221 LEU A CB  1 
ATOM 1256 C CG  . LEU A 1 300 ? 132.059 132.854 149.890 1.00 39.58  ? 221 LEU A CG  1 
ATOM 1257 C CD1 . LEU A 1 300 ? 132.787 131.631 150.422 1.00 41.00  ? 221 LEU A CD1 1 
ATOM 1258 C CD2 . LEU A 1 300 ? 131.652 132.654 148.447 1.00 39.73  ? 221 LEU A CD2 1 
ATOM 1259 N N   . PRO A 1 301 ? 127.907 134.362 151.163 1.00 43.79  ? 222 PRO A N   1 
ATOM 1260 C CA  . PRO A 1 301 ? 126.705 134.234 152.004 1.00 47.86  ? 222 PRO A CA  1 
ATOM 1261 C C   . PRO A 1 301 ? 126.778 133.092 153.003 1.00 56.54  ? 222 PRO A C   1 
ATOM 1262 O O   . PRO A 1 301 ? 126.051 133.117 154.003 1.00 57.36  ? 222 PRO A O   1 
ATOM 1263 C CB  . PRO A 1 301 ? 125.583 134.008 150.982 1.00 43.70  ? 222 PRO A CB  1 
ATOM 1264 C CG  . PRO A 1 301 ? 126.107 134.577 149.712 1.00 43.51  ? 222 PRO A CG  1 
ATOM 1265 C CD  . PRO A 1 301 ? 127.577 134.305 149.729 1.00 42.36  ? 222 PRO A CD  1 
ATOM 1266 N N   . GLU A 1 302 ? 127.627 132.091 152.762 1.00 58.16  ? 223 GLU A N   1 
ATOM 1267 C CA  . GLU A 1 302 ? 127.716 130.955 153.672 1.00 55.62  ? 223 GLU A CA  1 
ATOM 1268 C C   . GLU A 1 302 ? 128.450 131.317 154.958 1.00 55.65  ? 223 GLU A C   1 
ATOM 1269 O O   . GLU A 1 302 ? 128.029 130.918 156.049 1.00 57.78  ? 223 GLU A O   1 
ATOM 1270 C CB  . GLU A 1 302 ? 128.407 129.782 152.979 1.00 52.70  ? 223 GLU A CB  1 
ATOM 1271 C CG  . GLU A 1 302 ? 127.713 129.305 151.715 1.00 55.94  ? 223 GLU A CG  1 
ATOM 1272 C CD  . GLU A 1 302 ? 128.593 128.401 150.877 1.00 54.98  ? 223 GLU A CD  1 
ATOM 1273 O OE1 . GLU A 1 302 ? 129.803 128.688 150.766 1.00 53.13  ? 223 GLU A OE1 1 
ATOM 1274 O OE2 . GLU A 1 302 ? 128.078 127.403 150.332 1.00 54.92  ? 223 GLU A OE2 1 
ATOM 1275 N N   . LEU A 1 303 ? 129.548 132.069 154.857 1.00 50.45  ? 224 LEU A N   1 
ATOM 1276 C CA  . LEU A 1 303 ? 130.433 132.234 156.007 1.00 52.32  ? 224 LEU A CA  1 
ATOM 1277 C C   . LEU A 1 303 ? 130.121 133.482 156.831 1.00 52.96  ? 224 LEU A C   1 
ATOM 1278 O O   . LEU A 1 303 ? 129.742 133.378 158.001 1.00 57.23  ? 224 LEU A O   1 
ATOM 1279 C CB  . LEU A 1 303 ? 131.892 132.277 155.539 1.00 46.22  ? 224 LEU A CB  1 
ATOM 1280 C CG  . LEU A 1 303 ? 132.475 131.010 154.913 1.00 49.99  ? 224 LEU A CG  1 
ATOM 1281 C CD1 . LEU A 1 303 ? 133.869 131.283 154.375 1.00 44.71  ? 224 LEU A CD1 1 
ATOM 1282 C CD2 . LEU A 1 303 ? 132.498 129.873 155.918 1.00 57.83  ? 224 LEU A CD2 1 
ATOM 1283 N N   . LEU A 1 304 ? 130.279 134.669 156.236 1.00 49.23  ? 225 LEU A N   1 
ATOM 1284 C CA  . LEU A 1 304 ? 130.218 135.891 157.029 1.00 47.60  ? 225 LEU A CA  1 
ATOM 1285 C C   . LEU A 1 304 ? 129.560 137.055 156.291 1.00 46.84  ? 225 LEU A C   1 
ATOM 1286 O O   . LEU A 1 304 ? 129.742 138.208 156.695 1.00 43.96  ? 225 LEU A O   1 
ATOM 1287 C CB  . LEU A 1 304 ? 131.632 136.297 157.471 1.00 44.02  ? 225 LEU A CB  1 
ATOM 1288 C CG  . LEU A 1 304 ? 132.095 136.094 158.916 1.00 45.49  ? 225 LEU A CG  1 
ATOM 1289 C CD1 . LEU A 1 304 ? 133.445 136.756 159.128 1.00 42.32  ? 225 LEU A CD1 1 
ATOM 1290 C CD2 . LEU A 1 304 ? 131.092 136.635 159.906 1.00 46.87  ? 225 LEU A CD2 1 
ATOM 1291 N N   . GLY A 1 305 ? 128.794 136.797 155.234 1.00 49.57  ? 226 GLY A N   1 
ATOM 1292 C CA  . GLY A 1 305 ? 128.345 137.876 154.374 1.00 46.38  ? 226 GLY A CA  1 
ATOM 1293 C C   . GLY A 1 305 ? 126.846 138.065 154.250 1.00 49.12  ? 226 GLY A C   1 
ATOM 1294 O O   . GLY A 1 305 ? 126.342 138.315 153.152 1.00 49.03  ? 226 GLY A O   1 
ATOM 1295 N N   . LYS A 1 306 ? 126.121 137.955 155.357 1.00 46.88  ? 227 LYS A N   1 
ATOM 1296 C CA  . LYS A 1 306 ? 124.675 138.112 155.359 1.00 42.93  ? 227 LYS A CA  1 
ATOM 1297 C C   . LYS A 1 306 ? 124.283 139.485 155.899 1.00 43.58  ? 227 LYS A C   1 
ATOM 1298 O O   . LYS A 1 306 ? 125.108 140.231 156.431 1.00 45.58  ? 227 LYS A O   1 
ATOM 1299 C CB  . LYS A 1 306 ? 124.025 136.999 156.184 1.00 47.08  ? 227 LYS A CB  1 
ATOM 1300 C CG  . LYS A 1 306 ? 124.168 135.623 155.561 1.00 50.43  ? 227 LYS A CG  1 
ATOM 1301 C CD  . LYS A 1 306 ? 123.508 134.561 156.415 1.00 52.48  ? 227 LYS A CD  1 
ATOM 1302 C CE  . LYS A 1 306 ? 124.256 134.382 157.723 1.00 51.14  ? 227 LYS A CE  1 
ATOM 1303 N NZ  . LYS A 1 306 ? 125.650 133.911 157.504 1.00 49.28  ? 227 LYS A NZ  1 
ATOM 1304 N N   . GLU A 1 307 ? 122.997 139.818 155.738 1.00 45.78  ? 228 GLU A N   1 
ATOM 1305 C CA  . GLU A 1 307 ? 122.493 141.116 156.185 1.00 47.47  ? 228 GLU A CA  1 
ATOM 1306 C C   . GLU A 1 307 ? 122.544 141.249 157.702 1.00 49.72  ? 228 GLU A C   1 
ATOM 1307 O O   . GLU A 1 307 ? 122.903 142.309 158.228 1.00 46.63  ? 228 GLU A O   1 
ATOM 1308 C CB  . GLU A 1 307 ? 121.064 141.328 155.686 1.00 49.45  ? 228 GLU A CB  1 
ATOM 1309 C CG  . GLU A 1 307 ? 120.637 142.787 155.644 1.00 48.80  ? 228 GLU A CG  1 
ATOM 1310 C CD  . GLU A 1 307 ? 119.704 143.091 154.490 1.00 54.37  ? 228 GLU A CD  1 
ATOM 1311 O OE1 . GLU A 1 307 ? 119.476 142.191 153.655 1.00 56.38  ? 228 GLU A OE1 1 
ATOM 1312 O OE2 . GLU A 1 307 ? 119.197 144.231 154.420 1.00 55.57  ? 228 GLU A OE2 1 
ATOM 1313 N N   . SER A 1 308 ? 122.190 140.187 158.421 1.00 53.25  ? 229 SER A N   1 
ATOM 1314 C CA  . SER A 1 308 ? 122.236 140.185 159.877 1.00 53.37  ? 229 SER A CA  1 
ATOM 1315 C C   . SER A 1 308 ? 123.626 139.893 160.421 1.00 49.83  ? 229 SER A C   1 
ATOM 1316 O O   . SER A 1 308 ? 123.796 139.827 161.643 1.00 50.39  ? 229 SER A O   1 
ATOM 1317 C CB  . SER A 1 308 ? 121.246 139.159 160.430 1.00 49.62  ? 229 SER A CB  1 
ATOM 1318 O OG  . SER A 1 308 ? 121.857 137.887 160.560 1.00 46.80  ? 229 SER A OG  1 
ATOM 1319 N N   . THR A 1 309 ? 124.615 139.717 159.546 1.00 45.71  ? 230 THR A N   1 
ATOM 1320 C CA  . THR A 1 309 ? 125.937 139.248 159.924 1.00 43.98  ? 230 THR A CA  1 
ATOM 1321 C C   . THR A 1 309 ? 127.051 140.219 159.536 1.00 39.86  ? 230 THR A C   1 
ATOM 1322 O O   . THR A 1 309 ? 128.048 140.307 160.266 1.00 41.08  ? 230 THR A O   1 
ATOM 1323 C CB  . THR A 1 309 ? 126.158 137.850 159.301 1.00 47.88  ? 230 THR A CB  1 
ATOM 1324 O OG1 . THR A 1 309 ? 125.493 136.869 160.105 1.00 46.46  ? 230 THR A OG1 1 
ATOM 1325 C CG2 . THR A 1 309 ? 127.611 137.450 159.190 1.00 46.45  ? 230 THR A CG2 1 
ATOM 1326 N N   . TRP A 1 310 ? 126.847 141.047 158.497 1.00 36.49  ? 231 TRP A N   1 
ATOM 1327 C CA  . TRP A 1 310 ? 127.819 141.976 157.909 1.00 35.16  ? 231 TRP A CA  1 
ATOM 1328 C C   . TRP A 1 310 ? 128.641 142.861 158.858 1.00 40.00  ? 231 TRP A C   1 
ATOM 1329 O O   . TRP A 1 310 ? 129.782 143.173 158.494 1.00 43.73  ? 231 TRP A O   1 
ATOM 1330 C CB  . TRP A 1 310 ? 127.115 142.845 156.845 1.00 34.28  ? 231 TRP A CB  1 
ATOM 1331 C CG  . TRP A 1 310 ? 126.489 144.155 157.283 1.00 32.24  ? 231 TRP A CG  1 
ATOM 1332 C CD1 . TRP A 1 310 ? 125.159 144.384 157.481 1.00 35.32  ? 231 TRP A CD1 1 
ATOM 1333 C CD2 . TRP A 1 310 ? 127.146 145.415 157.523 1.00 31.24  ? 231 TRP A CD2 1 
ATOM 1334 N NE1 . TRP A 1 310 ? 124.948 145.686 157.857 1.00 34.95  ? 231 TRP A NE1 1 
ATOM 1335 C CE2 . TRP A 1 310 ? 126.150 146.340 157.890 1.00 32.47  ? 231 TRP A CE2 1 
ATOM 1336 C CE3 . TRP A 1 310 ? 128.476 145.843 157.476 1.00 30.40  ? 231 TRP A CE3 1 
ATOM 1337 C CZ2 . TRP A 1 310 ? 126.442 147.664 158.208 1.00 32.23  ? 231 TRP A CZ2 1 
ATOM 1338 C CZ3 . TRP A 1 310 ? 128.764 147.154 157.800 1.00 30.56  ? 231 TRP A CZ3 1 
ATOM 1339 C CH2 . TRP A 1 310 ? 127.751 148.050 158.157 1.00 33.83  ? 231 TRP A CH2 1 
ATOM 1340 N N   . PRO A 1 311 ? 128.166 143.310 160.037 1.00 40.13  ? 232 PRO A N   1 
ATOM 1341 C CA  . PRO A 1 311 ? 129.101 144.002 160.948 1.00 32.46  ? 232 PRO A CA  1 
ATOM 1342 C C   . PRO A 1 311 ? 130.235 143.125 161.447 1.00 32.73  ? 232 PRO A C   1 
ATOM 1343 O O   . PRO A 1 311 ? 131.270 143.657 161.867 1.00 33.96  ? 232 PRO A O   1 
ATOM 1344 C CB  . PRO A 1 311 ? 128.207 144.461 162.106 1.00 35.05  ? 232 PRO A CB  1 
ATOM 1345 C CG  . PRO A 1 311 ? 126.880 144.566 161.532 1.00 37.77  ? 232 PRO A CG  1 
ATOM 1346 C CD  . PRO A 1 311 ? 126.781 143.453 160.541 1.00 42.41  ? 232 PRO A CD  1 
ATOM 1347 N N   . TYR A 1 312 ? 130.085 141.803 161.398 1.00 34.89  ? 233 TYR A N   1 
ATOM 1348 C CA  . TYR A 1 312 ? 131.135 140.878 161.802 1.00 37.23  ? 233 TYR A CA  1 
ATOM 1349 C C   . TYR A 1 312 ? 132.139 140.609 160.688 1.00 37.07  ? 233 TYR A C   1 
ATOM 1350 O O   . TYR A 1 312 ? 132.924 139.662 160.796 1.00 38.87  ? 233 TYR A O   1 
ATOM 1351 C CB  . TYR A 1 312 ? 130.530 139.555 162.289 1.00 38.69  ? 233 TYR A CB  1 
ATOM 1352 C CG  . TYR A 1 312 ? 129.420 139.675 163.323 1.00 38.37  ? 233 TYR A CG  1 
ATOM 1353 C CD1 . TYR A 1 312 ? 129.380 140.732 164.230 1.00 37.76  ? 233 TYR A CD1 1 
ATOM 1354 C CD2 . TYR A 1 312 ? 128.401 138.734 163.376 1.00 42.93  ? 233 TYR A CD2 1 
ATOM 1355 C CE1 . TYR A 1 312 ? 128.363 140.839 165.160 1.00 44.72  ? 233 TYR A CE1 1 
ATOM 1356 C CE2 . TYR A 1 312 ? 127.381 138.833 164.303 1.00 49.12  ? 233 TYR A CE2 1 
ATOM 1357 C CZ  . TYR A 1 312 ? 127.367 139.886 165.191 1.00 53.59  ? 233 TYR A CZ  1 
ATOM 1358 O OH  . TYR A 1 312 ? 126.352 139.986 166.115 1.00 65.12  ? 233 TYR A OH  1 
ATOM 1359 N N   . LEU A 1 313 ? 132.125 141.407 159.621 1.00 37.92  ? 234 LEU A N   1 
ATOM 1360 C CA  . LEU A 1 313 ? 133.142 141.323 158.580 1.00 36.71  ? 234 LEU A CA  1 
ATOM 1361 C C   . LEU A 1 313 ? 134.343 142.199 158.900 1.00 38.15  ? 234 LEU A C   1 
ATOM 1362 O O   . LEU A 1 313 ? 135.488 141.773 158.722 1.00 40.41  ? 234 LEU A O   1 
ATOM 1363 C CB  . LEU A 1 313 ? 132.553 141.735 157.228 1.00 29.84  ? 234 LEU A CB  1 
ATOM 1364 C CG  . LEU A 1 313 ? 131.961 140.636 156.349 1.00 32.28  ? 234 LEU A CG  1 
ATOM 1365 C CD1 . LEU A 1 313 ? 130.826 141.193 155.508 1.00 32.68  ? 234 LEU A CD1 1 
ATOM 1366 C CD2 . LEU A 1 313 ? 133.027 140.009 155.471 1.00 35.01  ? 234 LEU A CD2 1 
ATOM 1367 N N   . PHE A 1 314 ? 134.094 143.421 159.372 1.00 37.98  ? 235 PHE A N   1 
ATOM 1368 C CA  . PHE A 1 314 ? 135.167 144.309 159.796 1.00 36.64  ? 235 PHE A CA  1 
ATOM 1369 C C   . PHE A 1 314 ? 135.630 144.022 161.217 1.00 38.76  ? 235 PHE A C   1 
ATOM 1370 O O   . PHE A 1 314 ? 136.711 144.475 161.606 1.00 38.58  ? 235 PHE A O   1 
ATOM 1371 C CB  . PHE A 1 314 ? 134.714 145.765 159.691 1.00 33.66  ? 235 PHE A CB  1 
ATOM 1372 C CG  . PHE A 1 314 ? 134.137 146.128 158.354 1.00 33.74  ? 235 PHE A CG  1 
ATOM 1373 C CD1 . PHE A 1 314 ? 134.964 146.430 157.286 1.00 37.24  ? 235 PHE A CD1 1 
ATOM 1374 C CD2 . PHE A 1 314 ? 132.766 146.177 158.167 1.00 31.53  ? 235 PHE A CD2 1 
ATOM 1375 C CE1 . PHE A 1 314 ? 134.435 146.768 156.056 1.00 35.75  ? 235 PHE A CE1 1 
ATOM 1376 C CE2 . PHE A 1 314 ? 132.231 146.514 156.940 1.00 29.30  ? 235 PHE A CE2 1 
ATOM 1377 C CZ  . PHE A 1 314 ? 133.067 146.810 155.884 1.00 30.54  ? 235 PHE A CZ  1 
ATOM 1378 N N   . GLY A 1 315 ? 134.837 143.286 161.998 1.00 40.93  ? 236 GLY A N   1 
ATOM 1379 C CA  . GLY A 1 315 ? 135.214 142.975 163.365 1.00 43.25  ? 236 GLY A CA  1 
ATOM 1380 C C   . GLY A 1 315 ? 136.323 141.954 163.484 1.00 43.79  ? 236 GLY A C   1 
ATOM 1381 O O   . GLY A 1 315 ? 137.015 141.924 164.506 1.00 46.79  ? 236 GLY A O   1 
ATOM 1382 N N   . VAL A 1 316 ? 136.512 141.114 162.460 1.00 38.54  ? 237 VAL A N   1 
ATOM 1383 C CA  . VAL A 1 316 ? 137.585 140.121 162.486 1.00 41.53  ? 237 VAL A CA  1 
ATOM 1384 C C   . VAL A 1 316 ? 138.927 140.689 162.058 1.00 43.76  ? 237 VAL A C   1 
ATOM 1385 O O   . VAL A 1 316 ? 139.913 139.944 162.017 1.00 44.86  ? 237 VAL A O   1 
ATOM 1386 C CB  . VAL A 1 316 ? 137.206 138.898 161.627 1.00 43.49  ? 237 VAL A CB  1 
ATOM 1387 C CG1 . VAL A 1 316 ? 135.770 138.505 161.890 1.00 44.32  ? 237 VAL A CG1 1 
ATOM 1388 C CG2 . VAL A 1 316 ? 137.387 139.204 160.160 1.00 39.86  ? 237 VAL A CG2 1 
ATOM 1389 N N   . ILE A 1 317 ? 138.999 141.989 161.754 1.00 43.59  ? 238 ILE A N   1 
ATOM 1390 C CA  . ILE A 1 317 ? 140.276 142.671 161.547 1.00 44.67  ? 238 ILE A CA  1 
ATOM 1391 C C   . ILE A 1 317 ? 141.107 142.656 162.830 1.00 50.08  ? 238 ILE A C   1 
ATOM 1392 O O   . ILE A 1 317 ? 142.346 142.681 162.786 1.00 53.33  ? 238 ILE A O   1 
ATOM 1393 C CB  . ILE A 1 317 ? 139.995 144.101 161.019 1.00 38.71  ? 238 ILE A CB  1 
ATOM 1394 C CG1 . ILE A 1 317 ? 139.483 144.040 159.579 1.00 38.62  ? 238 ILE A CG1 1 
ATOM 1395 C CG2 . ILE A 1 317 ? 141.203 145.026 161.090 1.00 39.22  ? 238 ILE A CG2 1 
ATOM 1396 C CD1 . ILE A 1 317 ? 138.761 145.286 159.133 1.00 38.76  ? 238 ILE A CD1 1 
ATOM 1397 N N   . VAL A 1 318 ? 140.441 142.557 163.984 1.00 49.00  ? 239 VAL A N   1 
ATOM 1398 C CA  . VAL A 1 318 ? 141.115 142.498 165.280 1.00 51.26  ? 239 VAL A CA  1 
ATOM 1399 C C   . VAL A 1 318 ? 142.014 141.266 165.375 1.00 56.93  ? 239 VAL A C   1 
ATOM 1400 O O   . VAL A 1 318 ? 143.116 141.327 165.937 1.00 62.09  ? 239 VAL A O   1 
ATOM 1401 C CB  . VAL A 1 318 ? 140.057 142.536 166.402 1.00 51.72  ? 239 VAL A CB  1 
ATOM 1402 C CG1 . VAL A 1 318 ? 140.627 142.111 167.744 1.00 58.10  ? 239 VAL A CG1 1 
ATOM 1403 C CG2 . VAL A 1 318 ? 139.440 143.921 166.499 1.00 49.27  ? 239 VAL A CG2 1 
ATOM 1404 N N   . VAL A 1 319 ? 141.573 140.141 164.794 1.00 54.30  ? 240 VAL A N   1 
ATOM 1405 C CA  . VAL A 1 319 ? 142.293 138.871 164.971 1.00 55.15  ? 240 VAL A CA  1 
ATOM 1406 C C   . VAL A 1 319 ? 143.704 138.877 164.381 1.00 58.24  ? 240 VAL A C   1 
ATOM 1407 O O   . VAL A 1 319 ? 144.624 138.381 165.052 1.00 61.77  ? 240 VAL A O   1 
ATOM 1408 C CB  . VAL A 1 319 ? 141.433 137.701 164.458 1.00 52.91  ? 240 VAL A CB  1 
ATOM 1409 C CG1 . VAL A 1 319 ? 141.959 136.378 164.993 1.00 53.82  ? 240 VAL A CG1 1 
ATOM 1410 C CG2 . VAL A 1 319 ? 139.976 137.900 164.837 1.00 52.03  ? 240 VAL A CG2 1 
ATOM 1411 N N   . PRO A 1 320 ? 143.952 139.373 163.152 1.00 57.07  ? 241 PRO A N   1 
ATOM 1412 C CA  . PRO A 1 320 ? 145.357 139.541 162.740 1.00 60.22  ? 241 PRO A CA  1 
ATOM 1413 C C   . PRO A 1 320 ? 146.136 140.521 163.598 1.00 62.30  ? 241 PRO A C   1 
ATOM 1414 O O   . PRO A 1 320 ? 147.342 140.332 163.797 1.00 64.64  ? 241 PRO A O   1 
ATOM 1415 C CB  . PRO A 1 320 ? 145.246 140.036 161.292 1.00 57.13  ? 241 PRO A CB  1 
ATOM 1416 C CG  . PRO A 1 320 ? 143.964 139.546 160.825 1.00 50.38  ? 241 PRO A CG  1 
ATOM 1417 C CD  . PRO A 1 320 ? 143.058 139.625 162.004 1.00 52.51  ? 241 PRO A CD  1 
ATOM 1418 N N   . ALA A 1 321 ? 145.484 141.572 164.102 1.00 59.95  ? 242 ALA A N   1 
ATOM 1419 C CA  . ALA A 1 321 ? 146.168 142.526 164.966 1.00 61.86  ? 242 ALA A CA  1 
ATOM 1420 C C   . ALA A 1 321 ? 146.543 141.897 166.303 1.00 66.79  ? 242 ALA A C   1 
ATOM 1421 O O   . ALA A 1 321 ? 147.632 142.152 166.829 1.00 70.21  ? 242 ALA A O   1 
ATOM 1422 C CB  . ALA A 1 321 ? 145.294 143.762 165.178 1.00 61.46  ? 242 ALA A CB  1 
ATOM 1423 N N   . VAL A 1 322 ? 145.651 141.079 166.866 1.00 63.03  ? 243 VAL A N   1 
ATOM 1424 C CA  . VAL A 1 322 ? 145.923 140.425 168.144 1.00 63.34  ? 243 VAL A CA  1 
ATOM 1425 C C   . VAL A 1 322 ? 147.035 139.392 167.999 1.00 69.32  ? 243 VAL A C   1 
ATOM 1426 O O   . VAL A 1 322 ? 147.950 139.329 168.829 1.00 73.67  ? 243 VAL A O   1 
ATOM 1427 C CB  . VAL A 1 322 ? 144.628 139.804 168.703 1.00 60.55  ? 243 VAL A CB  1 
ATOM 1428 C CG1 . VAL A 1 322 ? 144.929 138.746 169.756 1.00 63.79  ? 243 VAL A CG1 1 
ATOM 1429 C CG2 . VAL A 1 322 ? 143.747 140.885 169.294 1.00 65.89  ? 243 VAL A CG2 1 
ATOM 1430 N N   . VAL A 1 323 ? 146.983 138.582 166.935 1.00 67.97  ? 244 VAL A N   1 
ATOM 1431 C CA  . VAL A 1 323 ? 147.979 137.534 166.717 1.00 68.80  ? 244 VAL A CA  1 
ATOM 1432 C C   . VAL A 1 323 ? 149.363 138.144 166.518 1.00 73.54  ? 244 VAL A C   1 
ATOM 1433 O O   . VAL A 1 323 ? 150.363 137.645 167.051 1.00 80.45  ? 244 VAL A O   1 
ATOM 1434 C CB  . VAL A 1 323 ? 147.554 136.650 165.526 1.00 68.56  ? 244 VAL A CB  1 
ATOM 1435 C CG1 . VAL A 1 323 ? 148.754 136.013 164.832 1.00 67.76  ? 244 VAL A CG1 1 
ATOM 1436 C CG2 . VAL A 1 323 ? 146.573 135.584 165.986 1.00 74.17  ? 244 VAL A CG2 1 
ATOM 1437 N N   . GLN A 1 324 ? 149.434 139.252 165.778 1.00 72.13  ? 245 GLN A N   1 
ATOM 1438 C CA  . GLN A 1 324 ? 150.690 139.983 165.644 1.00 73.22  ? 245 GLN A CA  1 
ATOM 1439 C C   . GLN A 1 324 ? 151.131 140.571 166.982 1.00 75.20  ? 245 GLN A C   1 
ATOM 1440 O O   . GLN A 1 324 ? 152.326 140.589 167.297 1.00 78.20  ? 245 GLN A O   1 
ATOM 1441 C CB  . GLN A 1 324 ? 150.535 141.079 164.588 1.00 68.44  ? 245 GLN A CB  1 
ATOM 1442 C CG  . GLN A 1 324 ? 151.654 142.103 164.548 1.00 69.87  ? 245 GLN A CG  1 
ATOM 1443 C CD  . GLN A 1 324 ? 151.891 142.642 163.156 1.00 70.97  ? 245 GLN A CD  1 
ATOM 1444 O OE1 . GLN A 1 324 ? 151.611 143.807 162.873 1.00 68.43  ? 245 GLN A OE1 1 
ATOM 1445 N NE2 . GLN A 1 324 ? 152.405 141.795 162.274 1.00 71.97  ? 245 GLN A NE2 1 
ATOM 1446 N N   . LEU A 1 325 ? 150.175 141.024 167.799 1.00 74.16  ? 246 LEU A N   1 
ATOM 1447 C CA  . LEU A 1 325 ? 150.503 141.686 169.059 1.00 75.17  ? 246 LEU A CA  1 
ATOM 1448 C C   . LEU A 1 325 ? 151.111 140.746 170.094 1.00 77.00  ? 246 LEU A C   1 
ATOM 1449 O O   . LEU A 1 325 ? 151.708 141.226 171.062 1.00 82.87  ? 246 LEU A O   1 
ATOM 1450 C CB  . LEU A 1 325 ? 149.257 142.348 169.648 1.00 74.66  ? 246 LEU A CB  1 
ATOM 1451 C CG  . LEU A 1 325 ? 149.116 143.867 169.510 1.00 72.95  ? 246 LEU A CG  1 
ATOM 1452 C CD1 . LEU A 1 325 ? 148.241 144.417 170.622 1.00 79.27  ? 246 LEU A CD1 1 
ATOM 1453 C CD2 . LEU A 1 325 ? 150.472 144.560 169.509 1.00 70.60  ? 246 LEU A CD2 1 
ATOM 1454 N N   . LEU A 1 326 ? 150.972 139.432 169.927 1.00 76.70  ? 247 LEU A N   1 
ATOM 1455 C CA  . LEU A 1 326 ? 151.551 138.476 170.865 1.00 82.60  ? 247 LEU A CA  1 
ATOM 1456 C C   . LEU A 1 326 ? 152.910 137.956 170.413 1.00 88.27  ? 247 LEU A C   1 
ATOM 1457 O O   . LEU A 1 326 ? 153.866 137.963 171.194 1.00 95.59  ? 247 LEU A O   1 
ATOM 1458 C CB  . LEU A 1 326 ? 150.597 137.293 171.084 1.00 80.64  ? 247 LEU A CB  1 
ATOM 1459 C CG  . LEU A 1 326 ? 149.112 137.560 171.332 1.00 78.34  ? 247 LEU A CG  1 
ATOM 1460 C CD1 . LEU A 1 326 ? 148.391 136.259 171.636 1.00 77.47  ? 247 LEU A CD1 1 
ATOM 1461 C CD2 . LEU A 1 326 ? 148.920 138.550 172.469 1.00 78.64  ? 247 LEU A CD2 1 
ATOM 1462 N N   . SER A 1 327 ? 153.012 137.498 169.164 1.00 88.81  ? 248 SER A N   1 
ATOM 1463 C CA  . SER A 1 327 ? 154.236 136.846 168.709 1.00 94.37  ? 248 SER A CA  1 
ATOM 1464 C C   . SER A 1 327 ? 155.357 137.847 168.455 1.00 95.42  ? 248 SER A C   1 
ATOM 1465 O O   . SER A 1 327 ? 156.514 137.583 168.798 1.00 96.65  ? 248 SER A O   1 
ATOM 1466 C CB  . SER A 1 327 ? 153.949 136.035 167.448 1.00 91.34  ? 248 SER A CB  1 
ATOM 1467 O OG  . SER A 1 327 ? 153.540 136.887 166.396 1.00 85.77  ? 248 SER A OG  1 
ATOM 1468 N N   . LEU A 1 328 ? 155.034 138.992 167.846 1.00 92.65  ? 249 LEU A N   1 
ATOM 1469 C CA  . LEU A 1 328 ? 156.062 139.952 167.436 1.00 91.81  ? 249 LEU A CA  1 
ATOM 1470 C C   . LEU A 1 328 ? 156.891 140.541 168.580 1.00 95.65  ? 249 LEU A C   1 
ATOM 1471 O O   . LEU A 1 328 ? 158.124 140.604 168.427 1.00 98.58  ? 249 LEU A O   1 
ATOM 1472 C CB  . LEU A 1 328 ? 155.425 141.059 166.587 1.00 85.24  ? 249 LEU A CB  1 
ATOM 1473 C CG  . LEU A 1 328 ? 156.249 141.545 165.395 1.00 83.52  ? 249 LEU A CG  1 
ATOM 1474 C CD1 . LEU A 1 328 ? 156.464 140.414 164.405 1.00 89.56  ? 249 LEU A CD1 1 
ATOM 1475 C CD2 . LEU A 1 328 ? 155.581 142.727 164.717 1.00 77.18  ? 249 LEU A CD2 1 
ATOM 1476 N N   . PRO A 1 329 ? 156.328 141.007 169.711 1.00 93.53  ? 250 PRO A N   1 
ATOM 1477 C CA  . PRO A 1 329 ? 157.204 141.544 170.773 1.00 96.62  ? 250 PRO A CA  1 
ATOM 1478 C C   . PRO A 1 329 ? 158.129 140.517 171.408 1.00 102.78 ? 250 PRO A C   1 
ATOM 1479 O O   . PRO A 1 329 ? 159.136 140.908 172.010 1.00 104.94 ? 250 PRO A O   1 
ATOM 1480 C CB  . PRO A 1 329 ? 156.216 142.110 171.801 1.00 88.97  ? 250 PRO A CB  1 
ATOM 1481 C CG  . PRO A 1 329 ? 154.975 141.374 171.575 1.00 88.13  ? 250 PRO A CG  1 
ATOM 1482 C CD  . PRO A 1 329 ? 154.910 141.166 170.099 1.00 87.71  ? 250 PRO A CD  1 
ATOM 1483 N N   . PHE A 1 330 ? 157.818 139.223 171.306 1.00 103.43 ? 251 PHE A N   1 
ATOM 1484 C CA  . PHE A 1 330 ? 158.742 138.204 171.798 1.00 103.85 ? 251 PHE A CA  1 
ATOM 1485 C C   . PHE A 1 330 ? 160.005 138.150 170.947 1.00 106.03 ? 251 PHE A C   1 
ATOM 1486 O O   . PHE A 1 330 ? 161.101 137.910 171.466 1.00 107.42 ? 251 PHE A O   1 
ATOM 1487 C CB  . PHE A 1 330 ? 158.062 136.831 171.834 1.00 101.26 ? 251 PHE A CB  1 
ATOM 1488 C CG  . PHE A 1 330 ? 157.204 136.591 173.055 1.00 104.52 ? 251 PHE A CG  1 
ATOM 1489 C CD1 . PHE A 1 330 ? 156.406 137.593 173.590 1.00 105.37 ? 251 PHE A CD1 1 
ATOM 1490 C CD2 . PHE A 1 330 ? 157.205 135.349 173.671 1.00 105.00 ? 251 PHE A CD2 1 
ATOM 1491 C CE1 . PHE A 1 330 ? 155.626 137.359 174.708 1.00 106.09 ? 251 PHE A CE1 1 
ATOM 1492 C CE2 . PHE A 1 330 ? 156.428 135.109 174.790 1.00 106.10 ? 251 PHE A CE2 1 
ATOM 1493 C CZ  . PHE A 1 330 ? 155.638 136.116 175.309 1.00 104.86 ? 251 PHE A CZ  1 
ATOM 1494 N N   . LEU A 1 331 ? 159.868 138.367 169.642 1.00 106.62 ? 252 LEU A N   1 
ATOM 1495 C CA  . LEU A 1 331 ? 161.006 138.339 168.739 1.00 106.63 ? 252 LEU A CA  1 
ATOM 1496 C C   . LEU A 1 331 ? 161.894 139.566 168.951 1.00 107.57 ? 252 LEU A C   1 
ATOM 1497 O O   . LEU A 1 331 ? 161.419 140.614 169.396 1.00 109.19 ? 252 LEU A O   1 
ATOM 1498 C CB  . LEU A 1 331 ? 160.520 138.286 167.293 1.00 105.34 ? 252 LEU A CB  1 
ATOM 1499 C CG  . LEU A 1 331 ? 159.313 137.373 167.086 1.00 105.56 ? 252 LEU A CG  1 
ATOM 1500 C CD1 . LEU A 1 331 ? 158.633 137.674 165.769 1.00 105.60 ? 252 LEU A CD1 1 
ATOM 1501 C CD2 . LEU A 1 331 ? 159.728 135.912 167.156 1.00 105.89 ? 252 LEU A CD2 1 
ATOM 1502 N N   . PRO A 1 332 ? 163.189 139.457 168.654 1.00 107.96 ? 253 PRO A N   1 
ATOM 1503 C CA  . PRO A 1 332 ? 164.078 140.615 168.793 1.00 110.04 ? 253 PRO A CA  1 
ATOM 1504 C C   . PRO A 1 332 ? 163.782 141.693 167.761 1.00 110.06 ? 253 PRO A C   1 
ATOM 1505 O O   . PRO A 1 332 ? 163.129 141.464 166.740 1.00 110.07 ? 253 PRO A O   1 
ATOM 1506 C CB  . PRO A 1 332 ? 165.478 140.024 168.584 1.00 108.43 ? 253 PRO A CB  1 
ATOM 1507 C CG  . PRO A 1 332 ? 165.324 138.561 168.820 1.00 109.41 ? 253 PRO A CG  1 
ATOM 1508 C CD  . PRO A 1 332 ? 163.941 138.221 168.376 1.00 108.66 ? 253 PRO A CD  1 
ATOM 1509 N N   . ASP A 1 333 ? 164.283 142.893 168.052 1.00 107.61 ? 254 ASP A N   1 
ATOM 1510 C CA  . ASP A 1 333 ? 164.091 144.055 167.196 1.00 107.83 ? 254 ASP A CA  1 
ATOM 1511 C C   . ASP A 1 333 ? 164.883 143.912 165.897 1.00 110.04 ? 254 ASP A C   1 
ATOM 1512 O O   . ASP A 1 333 ? 165.604 142.936 165.670 1.00 111.81 ? 254 ASP A O   1 
ATOM 1513 C CB  . ASP A 1 333 ? 164.511 145.326 167.931 1.00 111.21 ? 254 ASP A CB  1 
ATOM 1514 C CG  . ASP A 1 333 ? 163.430 145.858 168.844 1.00 115.09 ? 254 ASP A CG  1 
ATOM 1515 O OD1 . ASP A 1 333 ? 162.464 146.457 168.330 1.00 112.50 ? 254 ASP A OD1 1 
ATOM 1516 O OD2 . ASP A 1 333 ? 163.544 145.676 170.075 1.00 120.35 ? 254 ASP A OD2 1 
ATOM 1517 N N   . SER A 1 334 ? 164.745 144.910 165.035 1.00 108.70 ? 255 SER A N   1 
ATOM 1518 C CA  . SER A 1 334 ? 165.527 144.959 163.807 1.00 111.86 ? 255 SER A CA  1 
ATOM 1519 C C   . SER A 1 334 ? 166.979 145.262 164.151 1.00 117.43 ? 255 SER A C   1 
ATOM 1520 O O   . SER A 1 334 ? 167.250 146.288 164.789 1.00 120.00 ? 255 SER A O   1 
ATOM 1521 C CB  . SER A 1 334 ? 164.965 146.014 162.862 1.00 111.81 ? 255 SER A CB  1 
ATOM 1522 O OG  . SER A 1 334 ? 165.955 146.467 161.957 1.00 116.91 ? 255 SER A OG  1 
ATOM 1523 N N   . PRO A 1 335 ? 167.929 144.396 163.783 1.00 115.29 ? 256 PRO A N   1 
ATOM 1524 C CA  . PRO A 1 335 ? 169.328 144.609 164.196 1.00 114.77 ? 256 PRO A CA  1 
ATOM 1525 C C   . PRO A 1 335 ? 169.967 145.868 163.633 1.00 117.10 ? 256 PRO A C   1 
ATOM 1526 O O   . PRO A 1 335 ? 170.847 146.443 164.286 1.00 118.62 ? 256 PRO A O   1 
ATOM 1527 C CB  . PRO A 1 335 ? 170.039 143.350 163.685 1.00 113.90 ? 256 PRO A CB  1 
ATOM 1528 C CG  . PRO A 1 335 ? 168.972 142.337 163.498 1.00 114.99 ? 256 PRO A CG  1 
ATOM 1529 C CD  . PRO A 1 335 ? 167.727 143.085 163.146 1.00 112.52 ? 256 PRO A CD  1 
ATOM 1530 N N   . ARG A 1 336 ? 169.560 146.315 162.442 1.00 115.64 ? 257 ARG A N   1 
ATOM 1531 C CA  . ARG A 1 336 ? 170.206 147.477 161.838 1.00 115.68 ? 257 ARG A CA  1 
ATOM 1532 C C   . ARG A 1 336 ? 169.794 148.774 162.523 1.00 118.45 ? 257 ARG A C   1 
ATOM 1533 O O   . ARG A 1 336 ? 170.598 149.709 162.615 1.00 122.69 ? 257 ARG A O   1 
ATOM 1534 C CB  . ARG A 1 336 ? 169.897 147.549 160.344 1.00 115.89 ? 257 ARG A CB  1 
ATOM 1535 C CG  . ARG A 1 336 ? 170.893 148.402 159.573 1.00 118.84 ? 257 ARG A CG  1 
ATOM 1536 C CD  . ARG A 1 336 ? 170.423 148.676 158.161 1.00 116.94 ? 257 ARG A CD  1 
ATOM 1537 N NE  . ARG A 1 336 ? 169.444 149.755 158.113 1.00 117.18 ? 257 ARG A NE  1 
ATOM 1538 C CZ  . ARG A 1 336 ? 169.747 151.037 157.967 1.00 120.11 ? 257 ARG A CZ  1 
ATOM 1539 N NH1 . ARG A 1 336 ? 170.999 151.440 157.830 1.00 120.57 ? 257 ARG A NH1 1 
ATOM 1540 N NH2 . ARG A 1 336 ? 168.769 151.937 157.954 1.00 123.34 ? 257 ARG A NH2 1 
ATOM 1541 N N   . TYR A 1 337 ? 168.545 148.863 162.989 1.00 117.50 ? 258 TYR A N   1 
ATOM 1542 C CA  . TYR A 1 337 ? 168.090 150.091 163.635 1.00 118.23 ? 258 TYR A CA  1 
ATOM 1543 C C   . TYR A 1 337 ? 168.794 150.310 164.968 1.00 119.44 ? 258 TYR A C   1 
ATOM 1544 O O   . TYR A 1 337 ? 169.279 151.411 165.253 1.00 118.97 ? 258 TYR A O   1 
ATOM 1545 C CB  . TYR A 1 337 ? 166.581 150.068 163.853 1.00 113.01 ? 258 TYR A CB  1 
ATOM 1546 C CG  . TYR A 1 337 ? 166.038 151.445 164.144 1.00 112.83 ? 258 TYR A CG  1 
ATOM 1547 C CD1 . TYR A 1 337 ? 166.157 152.469 163.214 1.00 116.12 ? 258 TYR A CD1 1 
ATOM 1548 C CD2 . TYR A 1 337 ? 165.493 151.747 165.383 1.00 111.06 ? 258 TYR A CD2 1 
ATOM 1549 C CE1 . TYR A 1 337 ? 165.681 153.738 163.482 1.00 115.82 ? 258 TYR A CE1 1 
ATOM 1550 C CE2 . TYR A 1 337 ? 165.028 153.017 165.667 1.00 110.81 ? 258 TYR A CE2 1 
ATOM 1551 C CZ  . TYR A 1 337 ? 165.121 154.006 164.713 1.00 113.57 ? 258 TYR A CZ  1 
ATOM 1552 O OH  . TYR A 1 337 ? 164.655 155.270 164.994 1.00 109.67 ? 258 TYR A OH  1 
ATOM 1553 N N   . LEU A 1 338 ? 168.849 149.271 165.802 1.00 119.91 ? 259 LEU A N   1 
ATOM 1554 C CA  . LEU A 1 338 ? 169.473 149.404 167.111 1.00 123.02 ? 259 LEU A CA  1 
ATOM 1555 C C   . LEU A 1 338 ? 170.988 149.541 167.018 1.00 124.73 ? 259 LEU A C   1 
ATOM 1556 O O   . LEU A 1 338 ? 171.611 150.045 167.958 1.00 126.26 ? 259 LEU A O   1 
ATOM 1557 C CB  . LEU A 1 338 ? 169.057 148.219 167.996 1.00 125.58 ? 259 LEU A CB  1 
ATOM 1558 C CG  . LEU A 1 338 ? 169.542 146.775 167.792 1.00 123.01 ? 259 LEU A CG  1 
ATOM 1559 C CD1 . LEU A 1 338 ? 170.867 146.477 168.482 1.00 125.39 ? 259 LEU A CD1 1 
ATOM 1560 C CD2 . LEU A 1 338 ? 168.473 145.796 168.251 1.00 119.09 ? 259 LEU A CD2 1 
ATOM 1561 N N   . LEU A 1 339 ? 171.593 149.093 165.915 1.00 123.71 ? 260 LEU A N   1 
ATOM 1562 C CA  . LEU A 1 339 ? 173.026 149.291 165.723 1.00 123.13 ? 260 LEU A CA  1 
ATOM 1563 C C   . LEU A 1 339 ? 173.353 150.754 165.452 1.00 124.35 ? 260 LEU A C   1 
ATOM 1564 O O   . LEU A 1 339 ? 174.247 151.328 166.084 1.00 127.59 ? 260 LEU A O   1 
ATOM 1565 C CB  . LEU A 1 339 ? 173.527 148.413 164.576 1.00 122.23 ? 260 LEU A CB  1 
ATOM 1566 C CG  . LEU A 1 339 ? 174.435 147.238 164.937 1.00 125.63 ? 260 LEU A CG  1 
ATOM 1567 C CD1 . LEU A 1 339 ? 175.262 146.826 163.734 1.00 131.76 ? 260 LEU A CD1 1 
ATOM 1568 C CD2 . LEU A 1 339 ? 175.342 147.594 166.103 1.00 125.78 ? 260 LEU A CD2 1 
ATOM 1569 N N   . LEU A 1 340 ? 172.636 151.375 164.515 1.00 122.14 ? 261 LEU A N   1 
ATOM 1570 C CA  . LEU A 1 340 ? 172.969 152.734 164.102 1.00 124.81 ? 261 LEU A CA  1 
ATOM 1571 C C   . LEU A 1 340 ? 172.495 153.775 165.109 1.00 127.88 ? 261 LEU A C   1 
ATOM 1572 O O   . LEU A 1 340 ? 173.178 154.783 165.325 1.00 125.82 ? 261 LEU A O   1 
ATOM 1573 C CB  . LEU A 1 340 ? 172.381 153.030 162.720 1.00 121.79 ? 261 LEU A CB  1 
ATOM 1574 C CG  . LEU A 1 340 ? 173.242 152.748 161.483 1.00 118.44 ? 261 LEU A CG  1 
ATOM 1575 C CD1 . LEU A 1 340 ? 173.575 151.270 161.335 1.00 120.34 ? 261 LEU A CD1 1 
ATOM 1576 C CD2 . LEU A 1 340 ? 172.560 153.278 160.231 1.00 117.78 ? 261 LEU A CD2 1 
ATOM 1577 N N   . GLU A 1 341 ? 171.335 153.563 165.724 1.00 128.40 ? 262 GLU A N   1 
ATOM 1578 C CA  . GLU A 1 341 ? 170.711 154.573 166.572 1.00 128.18 ? 262 GLU A CA  1 
ATOM 1579 C C   . GLU A 1 341 ? 170.794 154.269 168.059 1.00 129.70 ? 262 GLU A C   1 
ATOM 1580 O O   . GLU A 1 341 ? 171.078 155.172 168.848 1.00 130.30 ? 262 GLU A O   1 
ATOM 1581 C CB  . GLU A 1 341 ? 169.237 154.749 166.179 1.00 125.29 ? 262 GLU A CB  1 
ATOM 1582 C CG  . GLU A 1 341 ? 168.892 154.694 164.667 1.00 125.95 ? 262 GLU A CG  1 
ATOM 1583 C CD  . GLU A 1 341 ? 169.648 155.666 163.738 1.00 131.16 ? 262 GLU A CD  1 
ATOM 1584 O OE1 . GLU A 1 341 ? 169.374 155.607 162.518 1.00 129.56 ? 262 GLU A OE1 1 
ATOM 1585 O OE2 . GLU A 1 341 ? 170.446 156.519 164.179 1.00 135.21 ? 262 GLU A OE2 1 
ATOM 1586 N N   . LYS A 1 342 ? 170.555 153.024 168.468 1.00 129.57 ? 263 LYS A N   1 
ATOM 1587 C CA  . LYS A 1 342 ? 170.520 152.695 169.887 1.00 131.46 ? 263 LYS A CA  1 
ATOM 1588 C C   . LYS A 1 342 ? 171.892 152.370 170.465 1.00 134.05 ? 263 LYS A C   1 
ATOM 1589 O O   . LYS A 1 342 ? 172.041 152.389 171.694 1.00 135.28 ? 263 LYS A O   1 
ATOM 1590 C CB  . LYS A 1 342 ? 169.572 151.517 170.138 1.00 129.12 ? 263 LYS A CB  1 
ATOM 1591 C CG  . LYS A 1 342 ? 168.177 151.890 170.648 1.00 127.81 ? 263 LYS A CG  1 
ATOM 1592 C CD  . LYS A 1 342 ? 167.583 153.089 169.920 1.00 125.17 ? 263 LYS A CD  1 
ATOM 1593 C CE  . LYS A 1 342 ? 166.137 153.329 170.326 1.00 123.71 ? 263 LYS A CE  1 
ATOM 1594 N NZ  . LYS A 1 342 ? 165.584 154.562 169.701 1.00 120.40 ? 263 LYS A NZ  1 
ATOM 1595 N N   . HIS A 1 343 ? 172.882 152.082 169.611 1.00 131.97 ? 264 HIS A N   1 
ATOM 1596 C CA  . HIS A 1 343 ? 174.268 151.799 170.003 1.00 128.54 ? 264 HIS A CA  1 
ATOM 1597 C C   . HIS A 1 343 ? 174.341 150.625 170.984 1.00 131.52 ? 264 HIS A C   1 
ATOM 1598 O O   . HIS A 1 343 ? 174.811 150.745 172.117 1.00 133.78 ? 264 HIS A O   1 
ATOM 1599 C CB  . HIS A 1 343 ? 174.952 153.047 170.578 1.00 126.64 ? 264 HIS A CB  1 
ATOM 1600 C CG  . HIS A 1 343 ? 174.611 154.318 169.860 1.00 127.96 ? 264 HIS A CG  1 
ATOM 1601 N ND1 . HIS A 1 343 ? 174.448 154.385 168.493 1.00 127.57 ? 264 HIS A ND1 1 
ATOM 1602 C CD2 . HIS A 1 343 ? 174.397 155.571 170.326 1.00 128.63 ? 264 HIS A CD2 1 
ATOM 1603 C CE1 . HIS A 1 343 ? 174.155 155.626 168.147 1.00 126.29 ? 264 HIS A CE1 1 
ATOM 1604 N NE2 . HIS A 1 343 ? 174.115 156.365 169.241 1.00 126.26 ? 264 HIS A NE2 1 
ATOM 1605 N N   . ASN A 1 344 ? 173.859 149.477 170.520 1.00 131.84 ? 265 ASN A N   1 
ATOM 1606 C CA  . ASN A 1 344 ? 173.703 148.268 171.325 1.00 132.23 ? 265 ASN A CA  1 
ATOM 1607 C C   . ASN A 1 344 ? 174.375 147.082 170.647 1.00 131.58 ? 265 ASN A C   1 
ATOM 1608 O O   . ASN A 1 344 ? 173.737 146.070 170.349 1.00 131.89 ? 265 ASN A O   1 
ATOM 1609 C CB  . ASN A 1 344 ? 172.234 147.971 171.606 1.00 134.18 ? 265 ASN A CB  1 
ATOM 1610 C CG  . ASN A 1 344 ? 171.563 149.052 172.431 1.00 134.28 ? 265 ASN A CG  1 
ATOM 1611 O OD1 . ASN A 1 344 ? 170.357 149.264 172.327 1.00 134.44 ? 265 ASN A OD1 1 
ATOM 1612 N ND2 . ASN A 1 344 ? 172.339 149.730 173.268 1.00 133.22 ? 265 ASN A ND2 1 
ATOM 1613 N N   . GLU A 1 345 ? 175.670 147.241 170.335 1.00 131.79 ? 266 GLU A N   1 
ATOM 1614 C CA  . GLU A 1 345 ? 176.456 146.194 169.678 1.00 132.40 ? 266 GLU A CA  1 
ATOM 1615 C C   . GLU A 1 345 ? 176.396 144.862 170.420 1.00 131.64 ? 266 GLU A C   1 
ATOM 1616 O O   . GLU A 1 345 ? 176.365 143.796 169.793 1.00 131.78 ? 266 GLU A O   1 
ATOM 1617 C CB  . GLU A 1 345 ? 177.913 146.642 169.546 1.00 133.96 ? 266 GLU A CB  1 
ATOM 1618 C CG  . GLU A 1 345 ? 178.334 147.043 168.143 1.00 134.34 ? 266 GLU A CG  1 
ATOM 1619 C CD  . GLU A 1 345 ? 179.819 146.852 167.908 1.00 139.59 ? 266 GLU A CD  1 
ATOM 1620 O OE1 . GLU A 1 345 ? 180.565 146.720 168.900 1.00 139.88 ? 266 GLU A OE1 1 
ATOM 1621 O OE2 . GLU A 1 345 ? 180.241 146.836 166.733 1.00 142.61 ? 266 GLU A OE2 1 
ATOM 1622 N N   . ALA A 1 346 ? 176.394 144.901 171.756 1.00 129.26 ? 267 ALA A N   1 
ATOM 1623 C CA  . ALA A 1 346 ? 176.224 143.675 172.531 1.00 128.34 ? 267 ALA A CA  1 
ATOM 1624 C C   . ALA A 1 346 ? 174.839 143.076 172.318 1.00 130.40 ? 267 ALA A C   1 
ATOM 1625 O O   . ALA A 1 346 ? 174.695 141.855 172.176 1.00 129.34 ? 267 ALA A O   1 
ATOM 1626 C CB  . ALA A 1 346 ? 176.468 143.953 174.014 1.00 125.18 ? 267 ALA A CB  1 
ATOM 1627 N N   . ARG A 1 347 ? 173.806 143.921 172.292 1.00 131.97 ? 268 ARG A N   1 
ATOM 1628 C CA  . ARG A 1 347 ? 172.460 143.447 171.990 1.00 130.98 ? 268 ARG A CA  1 
ATOM 1629 C C   . ARG A 1 347 ? 172.312 143.081 170.519 1.00 130.17 ? 268 ARG A C   1 
ATOM 1630 O O   . ARG A 1 347 ? 171.492 142.221 170.176 1.00 128.35 ? 268 ARG A O   1 
ATOM 1631 C CB  . ARG A 1 347 ? 171.435 144.511 172.380 1.00 130.37 ? 268 ARG A CB  1 
ATOM 1632 C CG  . ARG A 1 347 ? 170.035 143.991 172.645 1.00 133.23 ? 268 ARG A CG  1 
ATOM 1633 C CD  . ARG A 1 347 ? 169.224 145.017 173.420 1.00 134.98 ? 268 ARG A CD  1 
ATOM 1634 N NE  . ARG A 1 347 ? 167.874 145.169 172.892 1.00 135.69 ? 268 ARG A NE  1 
ATOM 1635 C CZ  . ARG A 1 347 ? 167.129 146.254 173.048 1.00 132.38 ? 268 ARG A CZ  1 
ATOM 1636 N NH1 . ARG A 1 347 ? 167.573 147.307 173.714 1.00 128.86 ? 268 ARG A NH1 1 
ATOM 1637 N NH2 . ARG A 1 347 ? 165.908 146.285 172.521 1.00 129.30 ? 268 ARG A NH2 1 
ATOM 1638 N N   . ALA A 1 348 ? 173.083 143.731 169.641 1.00 130.59 ? 269 ALA A N   1 
ATOM 1639 C CA  . ALA A 1 348 ? 173.001 143.446 168.211 1.00 129.14 ? 269 ALA A CA  1 
ATOM 1640 C C   . ALA A 1 348 ? 173.482 142.037 167.894 1.00 130.57 ? 269 ALA A C   1 
ATOM 1641 O O   . ALA A 1 348 ? 172.927 141.371 167.012 1.00 129.51 ? 269 ALA A O   1 
ATOM 1642 C CB  . ALA A 1 348 ? 173.812 144.472 167.423 1.00 128.37 ? 269 ALA A CB  1 
ATOM 1643 N N   . VAL A 1 349 ? 174.527 141.577 168.588 1.00 131.79 ? 270 VAL A N   1 
ATOM 1644 C CA  . VAL A 1 349 ? 175.043 140.226 168.376 1.00 130.89 ? 270 VAL A CA  1 
ATOM 1645 C C   . VAL A 1 349 ? 173.993 139.190 168.759 1.00 131.45 ? 270 VAL A C   1 
ATOM 1646 O O   . VAL A 1 349 ? 173.752 138.227 168.021 1.00 132.14 ? 270 VAL A O   1 
ATOM 1647 C CB  . VAL A 1 349 ? 176.358 140.035 169.159 1.00 130.82 ? 270 VAL A CB  1 
ATOM 1648 C CG1 . VAL A 1 349 ? 176.629 138.561 169.447 1.00 129.94 ? 270 VAL A CG1 1 
ATOM 1649 C CG2 . VAL A 1 349 ? 177.520 140.654 168.398 1.00 130.58 ? 270 VAL A CG2 1 
ATOM 1650 N N   . LYS A 1 350 ? 173.334 139.388 169.905 1.00 131.24 ? 271 LYS A N   1 
ATOM 1651 C CA  . LYS A 1 350 ? 172.254 138.493 170.309 1.00 131.20 ? 271 LYS A CA  1 
ATOM 1652 C C   . LYS A 1 350 ? 171.073 138.583 169.351 1.00 132.54 ? 271 LYS A C   1 
ATOM 1653 O O   . LYS A 1 350 ? 170.431 137.570 169.048 1.00 133.56 ? 271 LYS A O   1 
ATOM 1654 C CB  . LYS A 1 350 ? 171.813 138.815 171.739 1.00 128.75 ? 271 LYS A CB  1 
ATOM 1655 C CG  . LYS A 1 350 ? 172.899 138.647 172.804 1.00 128.08 ? 271 LYS A CG  1 
ATOM 1656 C CD  . LYS A 1 350 ? 173.706 137.362 172.638 1.00 125.85 ? 271 LYS A CD  1 
ATOM 1657 C CE  . LYS A 1 350 ? 172.887 136.123 172.988 1.00 122.99 ? 271 LYS A CE  1 
ATOM 1658 N NZ  . LYS A 1 350 ? 173.477 134.889 172.400 1.00 122.88 ? 271 LYS A NZ  1 
ATOM 1659 N N   . ALA A 1 351 ? 170.765 139.791 168.873 1.00 132.81 ? 272 ALA A N   1 
ATOM 1660 C CA  . ALA A 1 351 ? 169.679 139.958 167.913 1.00 131.85 ? 272 ALA A CA  1 
ATOM 1661 C C   . ALA A 1 351 ? 170.020 139.333 166.565 1.00 130.14 ? 272 ALA A C   1 
ATOM 1662 O O   . ALA A 1 351 ? 169.160 138.712 165.931 1.00 128.08 ? 272 ALA A O   1 
ATOM 1663 C CB  . ALA A 1 351 ? 169.346 141.440 167.749 1.00 130.05 ? 272 ALA A CB  1 
ATOM 1664 N N   . PHE A 1 352 ? 171.265 139.498 166.105 1.00 129.50 ? 273 PHE A N   1 
ATOM 1665 C CA  . PHE A 1 352 ? 171.666 138.925 164.822 1.00 127.74 ? 273 PHE A CA  1 
ATOM 1666 C C   . PHE A 1 352 ? 171.668 137.402 164.865 1.00 130.01 ? 273 PHE A C   1 
ATOM 1667 O O   . PHE A 1 352 ? 171.239 136.749 163.907 1.00 128.66 ? 273 PHE A O   1 
ATOM 1668 C CB  . PHE A 1 352 ? 173.048 139.435 164.416 1.00 126.41 ? 273 PHE A CB  1 
ATOM 1669 C CG  . PHE A 1 352 ? 173.019 140.594 163.458 1.00 127.06 ? 273 PHE A CG  1 
ATOM 1670 C CD1 . PHE A 1 352 ? 172.557 140.429 162.163 1.00 128.30 ? 273 PHE A CD1 1 
ATOM 1671 C CD2 . PHE A 1 352 ? 173.494 141.838 163.842 1.00 127.74 ? 273 PHE A CD2 1 
ATOM 1672 C CE1 . PHE A 1 352 ? 172.541 141.491 161.276 1.00 126.47 ? 273 PHE A CE1 1 
ATOM 1673 C CE2 . PHE A 1 352 ? 173.486 142.903 162.959 1.00 125.25 ? 273 PHE A CE2 1 
ATOM 1674 C CZ  . PHE A 1 352 ? 173.007 142.729 161.676 1.00 125.10 ? 273 PHE A CZ  1 
ATOM 1675 N N   . GLN A 1 353 ? 172.153 136.818 165.967 1.00 131.63 ? 274 GLN A N   1 
ATOM 1676 C CA  . GLN A 1 353 ? 172.250 135.364 166.068 1.00 132.11 ? 274 GLN A CA  1 
ATOM 1677 C C   . GLN A 1 353 ? 170.881 134.696 166.103 1.00 132.66 ? 274 GLN A C   1 
ATOM 1678 O O   . GLN A 1 353 ? 170.753 133.536 165.697 1.00 133.83 ? 274 GLN A O   1 
ATOM 1679 C CB  . GLN A 1 353 ? 173.056 134.970 167.306 1.00 130.32 ? 274 GLN A CB  1 
ATOM 1680 C CG  . GLN A 1 353 ? 174.549 135.207 167.179 1.00 130.46 ? 274 GLN A CG  1 
ATOM 1681 C CD  . GLN A 1 353 ? 175.247 135.283 168.522 1.00 129.03 ? 274 GLN A CD  1 
ATOM 1682 O OE1 . GLN A 1 353 ? 174.671 135.740 169.508 1.00 129.38 ? 274 GLN A OE1 1 
ATOM 1683 N NE2 . GLN A 1 353 ? 176.496 134.833 168.565 1.00 129.53 ? 274 GLN A NE2 1 
ATOM 1684 N N   . THR A 1 354 ? 169.857 135.398 166.593 1.00 131.17 ? 275 THR A N   1 
ATOM 1685 C CA  . THR A 1 354 ? 168.518 134.820 166.631 1.00 129.07 ? 275 THR A CA  1 
ATOM 1686 C C   . THR A 1 354 ? 167.945 134.662 165.227 1.00 129.35 ? 275 THR A C   1 
ATOM 1687 O O   . THR A 1 354 ? 167.452 133.587 164.866 1.00 128.61 ? 275 THR A O   1 
ATOM 1688 C CB  . THR A 1 354 ? 167.598 135.685 167.494 1.00 126.26 ? 275 THR A CB  1 
ATOM 1689 O OG1 . THR A 1 354 ? 168.184 135.861 168.789 1.00 128.57 ? 275 THR A OG1 1 
ATOM 1690 C CG2 . THR A 1 354 ? 166.236 135.024 167.648 1.00 126.38 ? 275 THR A CG2 1 
ATOM 1691 N N   . PHE A 1 355 ? 168.016 135.718 164.414 1.00 129.19 ? 276 PHE A N   1 
ATOM 1692 C CA  . PHE A 1 355 ? 167.459 135.653 163.067 1.00 127.93 ? 276 PHE A CA  1 
ATOM 1693 C C   . PHE A 1 355 ? 168.339 134.861 162.108 1.00 129.34 ? 276 PHE A C   1 
ATOM 1694 O O   . PHE A 1 355 ? 167.818 134.217 161.191 1.00 128.78 ? 276 PHE A O   1 
ATOM 1695 C CB  . PHE A 1 355 ? 167.229 137.063 162.518 1.00 120.92 ? 276 PHE A CB  1 
ATOM 1696 C CG  . PHE A 1 355 ? 166.142 137.821 163.225 1.00 117.93 ? 276 PHE A CG  1 
ATOM 1697 C CD1 . PHE A 1 355 ? 164.827 137.727 162.798 1.00 116.43 ? 276 PHE A CD1 1 
ATOM 1698 C CD2 . PHE A 1 355 ? 166.433 138.633 164.308 1.00 118.42 ? 276 PHE A CD2 1 
ATOM 1699 C CE1 . PHE A 1 355 ? 163.821 138.424 163.442 1.00 115.73 ? 276 PHE A CE1 1 
ATOM 1700 C CE2 . PHE A 1 355 ? 165.432 139.333 164.958 1.00 117.56 ? 276 PHE A CE2 1 
ATOM 1701 C CZ  . PHE A 1 355 ? 164.124 139.228 164.524 1.00 115.22 ? 276 PHE A CZ  1 
ATOM 1702 N N   . LEU A 1 356 ? 169.658 134.892 162.294 1.00 129.86 ? 277 LEU A N   1 
ATOM 1703 C CA  . LEU A 1 356 ? 170.557 134.206 161.374 1.00 133.37 ? 277 LEU A CA  1 
ATOM 1704 C C   . LEU A 1 356 ? 170.814 132.759 161.765 1.00 137.05 ? 277 LEU A C   1 
ATOM 1705 O O   . LEU A 1 356 ? 171.038 131.919 160.885 1.00 139.23 ? 277 LEU A O   1 
ATOM 1706 C CB  . LEU A 1 356 ? 171.893 134.949 161.282 1.00 132.58 ? 277 LEU A CB  1 
ATOM 1707 C CG  . LEU A 1 356 ? 171.909 136.337 160.634 1.00 132.41 ? 277 LEU A CG  1 
ATOM 1708 C CD1 . LEU A 1 356 ? 173.298 136.657 160.103 1.00 133.38 ? 277 LEU A CD1 1 
ATOM 1709 C CD2 . LEU A 1 356 ? 170.870 136.461 159.528 1.00 128.84 ? 277 LEU A CD2 1 
ATOM 1710 N N   . GLY A 1 357 ? 170.789 132.446 163.058 1.00 136.28 ? 278 GLY A N   1 
ATOM 1711 C CA  . GLY A 1 357 ? 171.047 131.089 163.496 1.00 139.34 ? 278 GLY A CA  1 
ATOM 1712 C C   . GLY A 1 357 ? 172.490 130.654 163.395 1.00 140.28 ? 278 GLY A C   1 
ATOM 1713 O O   . GLY A 1 357 ? 172.764 129.451 163.382 1.00 140.10 ? 278 GLY A O   1 
ATOM 1714 N N   . LYS A 1 358 ? 173.426 131.598 163.326 1.00 139.55 ? 279 LYS A N   1 
ATOM 1715 C CA  . LYS A 1 358 ? 174.841 131.293 163.181 1.00 140.82 ? 279 LYS A CA  1 
ATOM 1716 C C   . LYS A 1 358 ? 175.636 132.008 164.264 1.00 139.96 ? 279 LYS A C   1 
ATOM 1717 O O   . LYS A 1 358 ? 175.252 133.084 164.732 1.00 136.81 ? 279 LYS A O   1 
ATOM 1718 C CB  . LYS A 1 358 ? 175.360 131.693 161.792 1.00 139.62 ? 279 LYS A CB  1 
ATOM 1719 C CG  . LYS A 1 358 ? 175.143 133.156 161.445 1.00 137.65 ? 279 LYS A CG  1 
ATOM 1720 C CD  . LYS A 1 358 ? 175.247 133.393 159.949 1.00 137.55 ? 279 LYS A CD  1 
ATOM 1721 C CE  . LYS A 1 358 ? 176.656 133.136 159.446 1.00 140.45 ? 279 LYS A CE  1 
ATOM 1722 N NZ  . LYS A 1 358 ? 177.463 134.387 159.401 1.00 138.47 ? 279 LYS A NZ  1 
ATOM 1723 N N   . ALA A 1 359 ? 176.750 131.392 164.664 1.00 141.26 ? 280 ALA A N   1 
ATOM 1724 C CA  . ALA A 1 359 ? 177.581 131.967 165.716 1.00 140.09 ? 280 ALA A CA  1 
ATOM 1725 C C   . ALA A 1 359 ? 178.574 132.981 165.161 1.00 139.44 ? 280 ALA A C   1 
ATOM 1726 O O   . ALA A 1 359 ? 178.849 133.999 165.807 1.00 139.45 ? 280 ALA A O   1 
ATOM 1727 C CB  . ALA A 1 359 ? 178.317 130.860 166.470 1.00 137.60 ? 280 ALA A CB  1 
ATOM 1728 N N   . ASP A 1 360 ? 179.117 132.731 163.971 1.00 138.27 ? 281 ASP A N   1 
ATOM 1729 C CA  . ASP A 1 360 ? 180.093 133.636 163.369 1.00 139.05 ? 281 ASP A CA  1 
ATOM 1730 C C   . ASP A 1 360 ? 179.319 134.756 162.686 1.00 140.35 ? 281 ASP A C   1 
ATOM 1731 O O   . ASP A 1 360 ? 178.748 134.573 161.609 1.00 140.41 ? 281 ASP A O   1 
ATOM 1732 C CB  . ASP A 1 360 ? 180.994 132.891 162.391 1.00 140.17 ? 281 ASP A CB  1 
ATOM 1733 C CG  . ASP A 1 360 ? 182.275 133.652 162.066 1.00 139.88 ? 281 ASP A CG  1 
ATOM 1734 O OD1 . ASP A 1 360 ? 182.253 134.900 162.002 1.00 138.44 ? 281 ASP A OD1 1 
ATOM 1735 O OD2 . ASP A 1 360 ? 183.316 132.992 161.872 1.00 140.58 ? 281 ASP A OD2 1 
ATOM 1736 N N   . VAL A 1 361 ? 179.304 135.926 163.321 1.00 140.84 ? 282 VAL A N   1 
ATOM 1737 C CA  . VAL A 1 361 ? 178.487 137.058 162.905 1.00 139.67 ? 282 VAL A CA  1 
ATOM 1738 C C   . VAL A 1 361 ? 179.346 138.274 162.559 1.00 138.49 ? 282 VAL A C   1 
ATOM 1739 O O   . VAL A 1 361 ? 178.854 139.216 161.925 1.00 137.26 ? 282 VAL A O   1 
ATOM 1740 C CB  . VAL A 1 361 ? 177.444 137.372 164.011 1.00 135.89 ? 282 VAL A CB  1 
ATOM 1741 C CG1 . VAL A 1 361 ? 176.552 138.591 163.762 1.00 134.08 ? 282 VAL A CG1 1 
ATOM 1742 C CG2 . VAL A 1 361 ? 176.565 136.154 164.261 1.00 134.01 ? 282 VAL A CG2 1 
ATOM 1743 N N   . SER A 1 362 ? 180.659 138.204 162.824 1.00 137.17 ? 283 SER A N   1 
ATOM 1744 C CA  . SER A 1 362 ? 181.546 139.369 162.766 1.00 135.90 ? 283 SER A CA  1 
ATOM 1745 C C   . SER A 1 362 ? 181.593 140.007 161.379 1.00 138.73 ? 283 SER A C   1 
ATOM 1746 O O   . SER A 1 362 ? 181.715 141.232 161.261 1.00 137.83 ? 283 SER A O   1 
ATOM 1747 C CB  . SER A 1 362 ? 182.953 138.968 163.208 1.00 136.51 ? 283 SER A CB  1 
ATOM 1748 O OG  . SER A 1 362 ? 183.433 137.873 162.446 1.00 136.07 ? 283 SER A OG  1 
ATOM 1749 N N   . GLN A 1 363 ? 181.507 139.200 160.318 1.00 139.32 ? 284 GLN A N   1 
ATOM 1750 C CA  . GLN A 1 363 ? 181.431 139.777 158.979 1.00 138.32 ? 284 GLN A CA  1 
ATOM 1751 C C   . GLN A 1 363 ? 180.103 140.486 158.740 1.00 139.74 ? 284 GLN A C   1 
ATOM 1752 O O   . GLN A 1 363 ? 180.051 141.455 157.974 1.00 138.99 ? 284 GLN A O   1 
ATOM 1753 C CB  . GLN A 1 363 ? 181.646 138.702 157.912 1.00 136.17 ? 284 GLN A CB  1 
ATOM 1754 C CG  . GLN A 1 363 ? 183.047 138.117 157.874 1.00 133.39 ? 284 GLN A CG  1 
ATOM 1755 C CD  . GLN A 1 363 ? 183.183 137.017 156.840 1.00 133.23 ? 284 GLN A CD  1 
ATOM 1756 O OE1 . GLN A 1 363 ? 182.202 136.368 156.474 1.00 133.24 ? 284 GLN A OE1 1 
ATOM 1757 N NE2 . GLN A 1 363 ? 184.402 136.806 156.356 1.00 130.17 ? 284 GLN A NE2 1 
ATOM 1758 N N   . GLU A 1 364 ? 179.026 140.026 159.380 1.00 141.54 ? 285 GLU A N   1 
ATOM 1759 C CA  . GLU A 1 364 ? 177.719 140.637 159.155 1.00 141.70 ? 285 GLU A CA  1 
ATOM 1760 C C   . GLU A 1 364 ? 177.613 141.990 159.847 1.00 140.31 ? 285 GLU A C   1 
ATOM 1761 O O   . GLU A 1 364 ? 177.014 142.923 159.300 1.00 136.61 ? 285 GLU A O   1 
ATOM 1762 C CB  . GLU A 1 364 ? 176.592 139.708 159.622 1.00 139.59 ? 285 GLU A CB  1 
ATOM 1763 C CG  . GLU A 1 364 ? 176.273 138.486 158.735 1.00 139.56 ? 285 GLU A CG  1 
ATOM 1764 C CD  . GLU A 1 364 ? 177.463 137.587 158.443 1.00 138.96 ? 285 GLU A CD  1 
ATOM 1765 O OE1 . GLU A 1 364 ? 178.284 137.364 159.358 1.00 139.02 ? 285 GLU A OE1 1 
ATOM 1766 O OE2 . GLU A 1 364 ? 177.577 137.106 157.296 1.00 138.64 ? 285 GLU A OE2 1 
ATOM 1767 N N   . VAL A 1 365 ? 178.176 142.114 161.053 1.00 141.00 ? 286 VAL A N   1 
ATOM 1768 C CA  . VAL A 1 365 ? 178.110 143.379 161.782 1.00 140.34 ? 286 VAL A CA  1 
ATOM 1769 C C   . VAL A 1 365 ? 178.928 144.450 161.075 1.00 139.38 ? 286 VAL A C   1 
ATOM 1770 O O   . VAL A 1 365 ? 178.448 145.566 160.848 1.00 137.37 ? 286 VAL A O   1 
ATOM 1771 C CB  . VAL A 1 365 ? 178.577 143.197 163.237 1.00 139.94 ? 286 VAL A CB  1 
ATOM 1772 C CG1 . VAL A 1 365 ? 178.098 144.360 164.092 1.00 137.79 ? 286 VAL A CG1 1 
ATOM 1773 C CG2 . VAL A 1 365 ? 178.070 141.894 163.797 1.00 135.53 ? 286 VAL A CG2 1 
ATOM 1774 N N   . GLU A 1 366 ? 180.170 144.121 160.701 1.00 139.55 ? 287 GLU A N   1 
ATOM 1775 C CA  . GLU A 1 366 ? 181.074 145.106 160.114 1.00 140.57 ? 287 GLU A CA  1 
ATOM 1776 C C   . GLU A 1 366 ? 180.586 145.623 158.768 1.00 140.67 ? 287 GLU A C   1 
ATOM 1777 O O   . GLU A 1 366 ? 180.964 146.730 158.372 1.00 139.97 ? 287 GLU A O   1 
ATOM 1778 C CB  . GLU A 1 366 ? 182.476 144.511 159.967 1.00 141.49 ? 287 GLU A CB  1 
ATOM 1779 C CG  . GLU A 1 366 ? 183.163 144.203 161.289 1.00 141.92 ? 287 GLU A CG  1 
ATOM 1780 C CD  . GLU A 1 366 ? 183.311 145.424 162.179 1.00 142.26 ? 287 GLU A CD  1 
ATOM 1781 O OE1 . GLU A 1 366 ? 183.627 146.514 161.657 1.00 140.07 ? 287 GLU A OE1 1 
ATOM 1782 O OE2 . GLU A 1 366 ? 183.110 145.292 163.405 1.00 144.34 ? 287 GLU A OE2 1 
ATOM 1783 N N   . GLU A 1 367 ? 179.757 144.851 158.062 1.00 140.54 ? 288 GLU A N   1 
ATOM 1784 C CA  . GLU A 1 367 ? 179.137 145.349 156.839 1.00 140.85 ? 288 GLU A CA  1 
ATOM 1785 C C   . GLU A 1 367 ? 178.130 146.453 157.148 1.00 140.42 ? 288 GLU A C   1 
ATOM 1786 O O   . GLU A 1 367 ? 177.994 147.411 156.377 1.00 140.99 ? 288 GLU A O   1 
ATOM 1787 C CB  . GLU A 1 367 ? 178.473 144.188 156.091 1.00 141.46 ? 288 GLU A CB  1 
ATOM 1788 C CG  . GLU A 1 367 ? 177.574 144.569 154.912 1.00 142.34 ? 288 GLU A CG  1 
ATOM 1789 C CD  . GLU A 1 367 ? 178.236 145.518 153.923 1.00 141.49 ? 288 GLU A CD  1 
ATOM 1790 O OE1 . GLU A 1 367 ? 179.431 145.330 153.609 1.00 137.94 ? 288 GLU A OE1 1 
ATOM 1791 O OE2 . GLU A 1 367 ? 177.555 146.457 153.459 1.00 143.41 ? 288 GLU A OE2 1 
ATOM 1792 N N   . VAL A 1 368 ? 177.422 146.336 158.276 1.00 139.10 ? 289 VAL A N   1 
ATOM 1793 C CA  . VAL A 1 368 ? 176.417 147.332 158.644 1.00 138.86 ? 289 VAL A CA  1 
ATOM 1794 C C   . VAL A 1 368 ? 177.074 148.676 158.945 1.00 138.34 ? 289 VAL A C   1 
ATOM 1795 O O   . VAL A 1 368 ? 176.607 149.727 158.490 1.00 137.72 ? 289 VAL A O   1 
ATOM 1796 C CB  . VAL A 1 368 ? 175.578 146.832 159.834 1.00 137.35 ? 289 VAL A CB  1 
ATOM 1797 C CG1 . VAL A 1 368 ? 174.514 147.848 160.196 1.00 131.83 ? 289 VAL A CG1 1 
ATOM 1798 C CG2 . VAL A 1 368 ? 174.943 145.493 159.506 1.00 135.84 ? 289 VAL A CG2 1 
ATOM 1799 N N   . LEU A 1 369 ? 178.171 148.666 159.710 1.00 138.92 ? 290 LEU A N   1 
ATOM 1800 C CA  . LEU A 1 369 ? 178.912 149.907 159.919 1.00 138.64 ? 290 LEU A CA  1 
ATOM 1801 C C   . LEU A 1 369 ? 179.630 150.358 158.653 1.00 138.60 ? 290 LEU A C   1 
ATOM 1802 O O   . LEU A 1 369 ? 179.885 151.556 158.486 1.00 136.41 ? 290 LEU A O   1 
ATOM 1803 C CB  . LEU A 1 369 ? 179.907 149.786 161.081 1.00 139.40 ? 290 LEU A CB  1 
ATOM 1804 C CG  . LEU A 1 369 ? 179.476 149.467 162.525 1.00 138.01 ? 290 LEU A CG  1 
ATOM 1805 C CD1 . LEU A 1 369 ? 178.364 150.415 162.977 1.00 138.12 ? 290 LEU A CD1 1 
ATOM 1806 C CD2 . LEU A 1 369 ? 179.109 148.018 162.799 1.00 135.41 ? 290 LEU A CD2 1 
ATOM 1807 N N   . ALA A 1 370 ? 179.969 149.424 157.758 1.00 140.14 ? 291 ALA A N   1 
ATOM 1808 C CA  . ALA A 1 370 ? 180.530 149.813 156.467 1.00 139.37 ? 291 ALA A CA  1 
ATOM 1809 C C   . ALA A 1 370 ? 179.502 150.556 155.623 1.00 138.56 ? 291 ALA A C   1 
ATOM 1810 O O   . ALA A 1 370 ? 179.845 151.495 154.895 1.00 137.09 ? 291 ALA A O   1 
ATOM 1811 C CB  . ALA A 1 370 ? 181.048 148.586 155.717 1.00 139.45 ? 291 ALA A CB  1 
ATOM 1812 N N   . GLU A 1 371 ? 178.236 150.142 155.696 1.00 138.93 ? 292 GLU A N   1 
ATOM 1813 C CA  . GLU A 1 371 ? 177.189 150.866 154.987 1.00 137.97 ? 292 GLU A CA  1 
ATOM 1814 C C   . GLU A 1 371 ? 176.843 152.176 155.683 1.00 136.39 ? 292 GLU A C   1 
ATOM 1815 O O   . GLU A 1 371 ? 176.480 153.151 155.016 1.00 134.81 ? 292 GLU A O   1 
ATOM 1816 C CB  . GLU A 1 371 ? 175.943 149.991 154.848 1.00 137.63 ? 292 GLU A CB  1 
ATOM 1817 C CG  . GLU A 1 371 ? 175.556 149.688 153.409 1.00 136.12 ? 292 GLU A CG  1 
ATOM 1818 C CD  . GLU A 1 371 ? 174.397 148.716 153.308 1.00 134.86 ? 292 GLU A CD  1 
ATOM 1819 O OE1 . GLU A 1 371 ? 173.592 148.646 154.260 1.00 136.11 ? 292 GLU A OE1 1 
ATOM 1820 O OE2 . GLU A 1 371 ? 174.292 148.019 152.277 1.00 134.68 ? 292 GLU A OE2 1 
ATOM 1821 N N   . SER A 1 372 ? 176.952 152.219 157.015 1.00 135.82 ? 293 SER A N   1 
ATOM 1822 C CA  . SER A 1 372 ? 176.526 153.401 157.759 1.00 134.26 ? 293 SER A CA  1 
ATOM 1823 C C   . SER A 1 372 ? 177.477 154.573 157.548 1.00 134.44 ? 293 SER A C   1 
ATOM 1824 O O   . SER A 1 372 ? 177.046 155.732 157.564 1.00 134.46 ? 293 SER A O   1 
ATOM 1825 C CB  . SER A 1 372 ? 176.412 153.078 159.248 1.00 133.49 ? 293 SER A CB  1 
ATOM 1826 O OG  . SER A 1 372 ? 177.692 152.926 159.832 1.00 133.96 ? 293 SER A OG  1 
ATOM 1827 N N   . ARG A 1 373 ? 178.775 154.298 157.375 1.00 135.66 ? 294 ARG A N   1 
ATOM 1828 C CA  . ARG A 1 373 ? 179.728 155.385 157.169 1.00 136.74 ? 294 ARG A CA  1 
ATOM 1829 C C   . ARG A 1 373 ? 179.497 156.075 155.828 1.00 138.31 ? 294 ARG A C   1 
ATOM 1830 O O   . ARG A 1 373 ? 179.659 157.295 155.718 1.00 137.95 ? 294 ARG A O   1 
ATOM 1831 C CB  . ARG A 1 373 ? 181.171 154.881 157.290 1.00 137.30 ? 294 ARG A CB  1 
ATOM 1832 C CG  . ARG A 1 373 ? 181.615 153.862 156.245 1.00 138.93 ? 294 ARG A CG  1 
ATOM 1833 C CD  . ARG A 1 373 ? 182.832 152.998 156.629 1.00 142.14 ? 294 ARG A CD  1 
ATOM 1834 N NE  . ARG A 1 373 ? 182.659 152.167 157.818 1.00 142.49 ? 294 ARG A NE  1 
ATOM 1835 C CZ  . ARG A 1 373 ? 182.945 152.538 159.060 1.00 139.68 ? 294 ARG A CZ  1 
ATOM 1836 N NH1 . ARG A 1 373 ? 183.486 153.716 159.325 1.00 136.18 ? 294 ARG A NH1 1 
ATOM 1837 N NH2 . ARG A 1 373 ? 182.708 151.693 160.059 1.00 138.12 ? 294 ARG A NH2 1 
ATOM 1838 N N   . VAL A 1 374 ? 179.118 155.314 154.798 1.00 138.04 ? 295 VAL A N   1 
ATOM 1839 C CA  . VAL A 1 374 ? 178.728 155.922 153.531 1.00 138.11 ? 295 VAL A CA  1 
ATOM 1840 C C   . VAL A 1 374 ? 177.374 156.608 153.663 1.00 138.71 ? 295 VAL A C   1 
ATOM 1841 O O   . VAL A 1 374 ? 177.160 157.698 153.118 1.00 138.55 ? 295 VAL A O   1 
ATOM 1842 C CB  . VAL A 1 374 ? 178.725 154.866 152.410 1.00 136.07 ? 295 VAL A CB  1 
ATOM 1843 C CG1 . VAL A 1 374 ? 178.642 155.538 151.048 1.00 135.77 ? 295 VAL A CG1 1 
ATOM 1844 C CG2 . VAL A 1 374 ? 179.964 153.993 152.504 1.00 134.01 ? 295 VAL A CG2 1 
ATOM 1845 N N   . GLN A 1 375 ? 176.437 155.976 154.381 1.00 137.22 ? 296 GLN A N   1 
ATOM 1846 C CA  . GLN A 1 375 ? 175.086 156.517 154.510 1.00 136.60 ? 296 GLN A CA  1 
ATOM 1847 C C   . GLN A 1 375 ? 175.076 157.828 155.287 1.00 137.80 ? 296 GLN A C   1 
ATOM 1848 O O   . GLN A 1 375 ? 174.320 158.748 154.953 1.00 137.06 ? 296 GLN A O   1 
ATOM 1849 C CB  . GLN A 1 375 ? 174.171 155.494 155.182 1.00 137.56 ? 296 GLN A CB  1 
ATOM 1850 C CG  . GLN A 1 375 ? 173.527 154.508 154.221 1.00 136.61 ? 296 GLN A CG  1 
ATOM 1851 C CD  . GLN A 1 375 ? 172.295 153.843 154.803 1.00 136.88 ? 296 GLN A CD  1 
ATOM 1852 O OE1 . GLN A 1 375 ? 172.272 152.631 155.015 1.00 134.12 ? 296 GLN A OE1 1 
ATOM 1853 N NE2 . GLN A 1 375 ? 171.257 154.633 155.055 1.00 134.54 ? 296 GLN A NE2 1 
ATOM 1854 N N   . ARG A 1 376 ? 175.896 157.931 156.332 1.00 139.31 ? 297 ARG A N   1 
ATOM 1855 C CA  . ARG A 1 376 ? 175.982 159.175 157.083 1.00 140.85 ? 297 ARG A CA  1 
ATOM 1856 C C   . ARG A 1 376 ? 176.780 160.246 156.352 1.00 138.84 ? 297 ARG A C   1 
ATOM 1857 O O   . ARG A 1 376 ? 176.616 161.434 156.653 1.00 139.14 ? 297 ARG A O   1 
ATOM 1858 C CB  . ARG A 1 376 ? 176.599 158.914 158.460 1.00 142.24 ? 297 ARG A CB  1 
ATOM 1859 C CG  . ARG A 1 376 ? 176.014 159.764 159.577 1.00 141.74 ? 297 ARG A CG  1 
ATOM 1860 C CD  . ARG A 1 376 ? 176.924 159.842 160.805 1.00 141.88 ? 297 ARG A CD  1 
ATOM 1861 N NE  . ARG A 1 376 ? 177.935 160.891 160.712 1.00 146.07 ? 297 ARG A NE  1 
ATOM 1862 C CZ  . ARG A 1 376 ? 179.139 160.745 160.173 1.00 145.22 ? 297 ARG A CZ  1 
ATOM 1863 N NH1 . ARG A 1 376 ? 179.555 159.577 159.712 1.00 146.14 ? 297 ARG A NH1 1 
ATOM 1864 N NH2 . ARG A 1 376 ? 179.954 161.793 160.116 1.00 142.35 ? 297 ARG A NH2 1 
ATOM 1865 N N   . SER A 1 377 ? 177.633 159.858 155.401 1.00 137.30 ? 298 SER A N   1 
ATOM 1866 C CA  . SER A 1 377 ? 178.462 160.829 154.694 1.00 138.77 ? 298 SER A CA  1 
ATOM 1867 C C   . SER A 1 377 ? 177.678 161.590 153.630 1.00 138.34 ? 298 SER A C   1 
ATOM 1868 O O   . SER A 1 377 ? 177.921 162.783 153.417 1.00 137.76 ? 298 SER A O   1 
ATOM 1869 C CB  . SER A 1 377 ? 179.664 160.130 154.059 1.00 141.19 ? 298 SER A CB  1 
ATOM 1870 O OG  . SER A 1 377 ? 179.280 159.405 152.904 1.00 139.51 ? 298 SER A OG  1 
ATOM 1871 N N   . ILE A 1 378 ? 176.746 160.922 152.947 1.00 136.39 ? 299 ILE A N   1 
ATOM 1872 C CA  . ILE A 1 378 ? 176.049 161.553 151.833 1.00 133.46 ? 299 ILE A CA  1 
ATOM 1873 C C   . ILE A 1 378 ? 175.021 162.551 152.353 1.00 130.61 ? 299 ILE A C   1 
ATOM 1874 O O   . ILE A 1 378 ? 174.406 162.360 153.410 1.00 128.27 ? 299 ILE A O   1 
ATOM 1875 C CB  . ILE A 1 378 ? 175.383 160.500 150.928 1.00 132.97 ? 299 ILE A CB  1 
ATOM 1876 C CG1 . ILE A 1 378 ? 174.722 159.409 151.772 1.00 135.58 ? 299 ILE A CG1 1 
ATOM 1877 C CG2 . ILE A 1 378 ? 176.399 159.911 149.959 1.00 131.36 ? 299 ILE A CG2 1 
ATOM 1878 C CD1 . ILE A 1 378 ? 174.164 158.253 150.967 1.00 125.61 ? 299 ILE A CD1 1 
ATOM 1879 N N   . ARG A 1 379 ? 174.837 163.632 151.600 1.00 128.52 ? 300 ARG A N   1 
ATOM 1880 C CA  . ARG A 1 379 ? 173.853 164.652 151.931 1.00 124.86 ? 300 ARG A CA  1 
ATOM 1881 C C   . ARG A 1 379 ? 172.490 164.222 151.405 1.00 122.06 ? 300 ARG A C   1 
ATOM 1882 O O   . ARG A 1 379 ? 172.351 163.888 150.224 1.00 120.89 ? 300 ARG A O   1 
ATOM 1883 C CB  . ARG A 1 379 ? 174.264 166.003 151.342 1.00 125.64 ? 300 ARG A CB  1 
ATOM 1884 C CG  . ARG A 1 379 ? 175.492 166.641 151.983 1.00 124.28 ? 300 ARG A CG  1 
ATOM 1885 C CD  . ARG A 1 379 ? 175.652 168.103 151.574 1.00 121.38 ? 300 ARG A CD  1 
ATOM 1886 N NE  . ARG A 1 379 ? 175.870 168.260 150.140 1.00 120.52 ? 300 ARG A NE  1 
ATOM 1887 C CZ  . ARG A 1 379 ? 177.054 168.192 149.548 1.00 119.79 ? 300 ARG A CZ  1 
ATOM 1888 N NH1 . ARG A 1 379 ? 178.164 167.990 150.240 1.00 122.05 ? 300 ARG A NH1 1 
ATOM 1889 N NH2 . ARG A 1 379 ? 177.128 168.336 148.228 1.00 116.44 ? 300 ARG A NH2 1 
ATOM 1890 N N   . LEU A 1 380 ? 171.491 164.230 152.283 1.00 119.40 ? 301 LEU A N   1 
ATOM 1891 C CA  . LEU A 1 380 ? 170.157 163.788 151.902 1.00 114.81 ? 301 LEU A CA  1 
ATOM 1892 C C   . LEU A 1 380 ? 169.489 164.848 151.035 1.00 111.75 ? 301 LEU A C   1 
ATOM 1893 O O   . LEU A 1 380 ? 169.443 166.027 151.398 1.00 113.66 ? 301 LEU A O   1 
ATOM 1894 C CB  . LEU A 1 380 ? 169.321 163.508 153.153 1.00 114.10 ? 301 LEU A CB  1 
ATOM 1895 C CG  . LEU A 1 380 ? 167.789 163.479 153.100 1.00 114.07 ? 301 LEU A CG  1 
ATOM 1896 C CD1 . LEU A 1 380 ? 167.268 162.441 152.108 1.00 111.42 ? 301 LEU A CD1 1 
ATOM 1897 C CD2 . LEU A 1 380 ? 167.209 163.235 154.486 1.00 113.81 ? 301 LEU A CD2 1 
ATOM 1898 N N   . VAL A 1 381 ? 168.971 164.425 149.887 1.00 108.52 ? 302 VAL A N   1 
ATOM 1899 C CA  . VAL A 1 381 ? 168.281 165.329 148.975 1.00 108.50 ? 302 VAL A CA  1 
ATOM 1900 C C   . VAL A 1 381 ? 166.858 165.537 149.475 1.00 109.64 ? 302 VAL A C   1 
ATOM 1901 O O   . VAL A 1 381 ? 166.159 164.575 149.811 1.00 110.11 ? 302 VAL A O   1 
ATOM 1902 C CB  . VAL A 1 381 ? 168.296 164.771 147.543 1.00 105.38 ? 302 VAL A CB  1 
ATOM 1903 C CG1 . VAL A 1 381 ? 167.560 165.702 146.591 1.00 102.59 ? 302 VAL A CG1 1 
ATOM 1904 C CG2 . VAL A 1 381 ? 169.727 164.552 147.075 1.00 106.37 ? 302 VAL A CG2 1 
ATOM 1905 N N   . SER A 1 382 ? 166.431 166.796 149.546 1.00 110.83 ? 303 SER A N   1 
ATOM 1906 C CA  . SER A 1 382 ? 165.073 167.092 149.971 1.00 109.95 ? 303 SER A CA  1 
ATOM 1907 C C   . SER A 1 382 ? 164.085 166.764 148.852 1.00 105.96 ? 303 SER A C   1 
ATOM 1908 O O   . SER A 1 382 ? 164.459 166.524 147.700 1.00 105.21 ? 303 SER A O   1 
ATOM 1909 C CB  . SER A 1 382 ? 164.942 168.557 150.383 1.00 110.91 ? 303 SER A CB  1 
ATOM 1910 O OG  . SER A 1 382 ? 164.953 169.406 149.252 1.00 106.22 ? 303 SER A OG  1 
ATOM 1911 N N   . VAL A 1 383 ? 162.802 166.743 149.216 1.00 104.16 ? 304 VAL A N   1 
ATOM 1912 C CA  . VAL A 1 383 ? 161.754 166.396 148.260 1.00 98.58  ? 304 VAL A CA  1 
ATOM 1913 C C   . VAL A 1 383 ? 161.619 167.479 147.196 1.00 102.53 ? 304 VAL A C   1 
ATOM 1914 O O   . VAL A 1 383 ? 161.540 167.187 145.997 1.00 103.14 ? 304 VAL A O   1 
ATOM 1915 C CB  . VAL A 1 383 ? 160.421 166.161 148.994 1.00 97.61  ? 304 VAL A CB  1 
ATOM 1916 C CG1 . VAL A 1 383 ? 159.310 165.842 148.002 1.00 89.60  ? 304 VAL A CG1 1 
ATOM 1917 C CG2 . VAL A 1 383 ? 160.571 165.058 150.026 1.00 97.50  ? 304 VAL A CG2 1 
ATOM 1918 N N   . LEU A 1 384 ? 161.603 168.746 147.619 1.00 105.74 ? 305 LEU A N   1 
ATOM 1919 C CA  . LEU A 1 384 ? 161.388 169.843 146.679 1.00 105.63 ? 305 LEU A CA  1 
ATOM 1920 C C   . LEU A 1 384 ? 162.580 170.042 145.751 1.00 106.20 ? 305 LEU A C   1 
ATOM 1921 O O   . LEU A 1 384 ? 162.410 170.527 144.627 1.00 107.15 ? 305 LEU A O   1 
ATOM 1922 C CB  . LEU A 1 384 ? 161.085 171.135 147.438 1.00 104.17 ? 305 LEU A CB  1 
ATOM 1923 C CG  . LEU A 1 384 ? 160.277 172.218 146.714 1.00 100.34 ? 305 LEU A CG  1 
ATOM 1924 C CD1 . LEU A 1 384 ? 159.320 171.621 145.686 1.00 98.07  ? 305 LEU A CD1 1 
ATOM 1925 C CD2 . LEU A 1 384 ? 159.518 173.077 147.716 1.00 101.34 ? 305 LEU A CD2 1 
ATOM 1926 N N   . GLU A 1 385 ? 163.786 169.683 146.199 1.00 104.62 ? 306 GLU A N   1 
ATOM 1927 C CA  . GLU A 1 385 ? 164.956 169.796 145.334 1.00 107.54 ? 306 GLU A CA  1 
ATOM 1928 C C   . GLU A 1 385 ? 164.918 168.787 144.194 1.00 106.09 ? 306 GLU A C   1 
ATOM 1929 O O   . GLU A 1 385 ? 165.443 169.064 143.110 1.00 107.49 ? 306 GLU A O   1 
ATOM 1930 C CB  . GLU A 1 385 ? 166.240 169.623 146.150 1.00 108.83 ? 306 GLU A CB  1 
ATOM 1931 C CG  . GLU A 1 385 ? 166.704 170.863 146.922 1.00 108.88 ? 306 GLU A CG  1 
ATOM 1932 C CD  . GLU A 1 385 ? 167.002 172.072 146.042 1.00 112.16 ? 306 GLU A CD  1 
ATOM 1933 O OE1 . GLU A 1 385 ? 167.305 171.903 144.840 1.00 115.80 ? 306 GLU A OE1 1 
ATOM 1934 O OE2 . GLU A 1 385 ? 166.933 173.205 146.562 1.00 110.62 ? 306 GLU A OE2 1 
ATOM 1935 N N   . LEU A 1 386 ? 164.312 167.619 144.416 1.00 103.07 ? 307 LEU A N   1 
ATOM 1936 C CA  . LEU A 1 386 ? 164.307 166.582 143.388 1.00 100.70 ? 307 LEU A CA  1 
ATOM 1937 C C   . LEU A 1 386 ? 163.381 166.943 142.231 1.00 99.51  ? 307 LEU A C   1 
ATOM 1938 O O   . LEU A 1 386 ? 163.680 166.630 141.073 1.00 102.52 ? 307 LEU A O   1 
ATOM 1939 C CB  . LEU A 1 386 ? 163.917 165.239 144.002 1.00 98.23  ? 307 LEU A CB  1 
ATOM 1940 C CG  . LEU A 1 386 ? 164.184 164.018 143.125 1.00 93.25  ? 307 LEU A CG  1 
ATOM 1941 C CD1 . LEU A 1 386 ? 165.672 163.802 143.008 1.00 95.41  ? 307 LEU A CD1 1 
ATOM 1942 C CD2 . LEU A 1 386 ? 163.533 162.786 143.712 1.00 86.53  ? 307 LEU A CD2 1 
ATOM 1943 N N   . LEU A 1 387 ? 162.251 167.592 142.523 1.00 97.04  ? 308 LEU A N   1 
ATOM 1944 C CA  . LEU A 1 387 ? 161.357 168.030 141.454 1.00 100.36 ? 308 LEU A CA  1 
ATOM 1945 C C   . LEU A 1 387 ? 161.981 169.150 140.629 1.00 102.90 ? 308 LEU A C   1 
ATOM 1946 O O   . LEU A 1 387 ? 161.798 169.205 139.408 1.00 101.71 ? 308 LEU A O   1 
ATOM 1947 C CB  . LEU A 1 387 ? 160.013 168.477 142.030 1.00 95.73  ? 308 LEU A CB  1 
ATOM 1948 C CG  . LEU A 1 387 ? 158.975 167.394 142.342 1.00 91.54  ? 308 LEU A CG  1 
ATOM 1949 C CD1 . LEU A 1 387 ? 159.204 166.770 143.707 1.00 90.75  ? 308 LEU A CD1 1 
ATOM 1950 C CD2 . LEU A 1 387 ? 157.566 167.960 142.238 1.00 91.90  ? 308 LEU A CD2 1 
ATOM 1951 N N   . ARG A 1 388 ? 162.721 170.050 141.276 1.00 103.93 ? 309 ARG A N   1 
ATOM 1952 C CA  . ARG A 1 388 ? 163.322 171.181 140.582 1.00 105.31 ? 309 ARG A CA  1 
ATOM 1953 C C   . ARG A 1 388 ? 164.670 170.854 139.951 1.00 107.51 ? 309 ARG A C   1 
ATOM 1954 O O   . ARG A 1 388 ? 165.213 171.696 139.228 1.00 110.13 ? 309 ARG A O   1 
ATOM 1955 C CB  . ARG A 1 388 ? 163.484 172.362 141.544 1.00 107.06 ? 309 ARG A CB  1 
ATOM 1956 C CG  . ARG A 1 388 ? 162.195 172.801 142.225 1.00 107.49 ? 309 ARG A CG  1 
ATOM 1957 C CD  . ARG A 1 388 ? 161.454 173.854 141.413 1.00 108.64 ? 309 ARG A CD  1 
ATOM 1958 N NE  . ARG A 1 388 ? 160.663 173.270 140.337 1.00 107.98 ? 309 ARG A NE  1 
ATOM 1959 C CZ  . ARG A 1 388 ? 159.788 173.943 139.601 1.00 107.76 ? 309 ARG A CZ  1 
ATOM 1960 N NH1 . ARG A 1 388 ? 159.568 175.232 139.796 1.00 108.04 ? 309 ARG A NH1 1 
ATOM 1961 N NH2 . ARG A 1 388 ? 159.118 173.305 138.645 1.00 107.39 ? 309 ARG A NH2 1 
ATOM 1962 N N   . ALA A 1 389 ? 165.220 169.671 140.202 1.00 107.55 ? 310 ALA A N   1 
ATOM 1963 C CA  . ALA A 1 389 ? 166.522 169.315 139.652 1.00 107.17 ? 310 ALA A CA  1 
ATOM 1964 C C   . ALA A 1 389 ? 166.385 168.947 138.180 1.00 104.26 ? 310 ALA A C   1 
ATOM 1965 O O   . ALA A 1 389 ? 165.652 168.007 137.854 1.00 104.04 ? 310 ALA A O   1 
ATOM 1966 C CB  . ALA A 1 389 ? 167.132 168.154 140.425 1.00 107.48 ? 310 ALA A CB  1 
ATOM 1967 N N   . PRO A 1 390 ? 167.062 169.650 137.267 1.00 105.07 ? 311 PRO A N   1 
ATOM 1968 C CA  . PRO A 1 390 ? 166.955 169.294 135.844 1.00 107.01 ? 311 PRO A CA  1 
ATOM 1969 C C   . PRO A 1 390 ? 167.709 168.031 135.474 1.00 105.21 ? 311 PRO A C   1 
ATOM 1970 O O   . PRO A 1 390 ? 167.450 167.471 134.402 1.00 106.01 ? 311 PRO A O   1 
ATOM 1971 C CB  . PRO A 1 390 ? 167.543 170.519 135.133 1.00 111.00 ? 311 PRO A CB  1 
ATOM 1972 C CG  . PRO A 1 390 ? 168.505 171.085 136.123 1.00 110.99 ? 311 PRO A CG  1 
ATOM 1973 C CD  . PRO A 1 390 ? 167.901 170.841 137.480 1.00 105.78 ? 311 PRO A CD  1 
ATOM 1974 N N   . TYR A 1 391 ? 168.636 167.570 136.319 1.00 103.25 ? 312 TYR A N   1 
ATOM 1975 C CA  . TYR A 1 391 ? 169.411 166.376 135.997 1.00 105.22 ? 312 TYR A CA  1 
ATOM 1976 C C   . TYR A 1 391 ? 168.561 165.114 136.052 1.00 100.87 ? 312 TYR A C   1 
ATOM 1977 O O   . TYR A 1 391 ? 168.789 164.181 135.274 1.00 101.17 ? 312 TYR A O   1 
ATOM 1978 C CB  . TYR A 1 391 ? 170.604 166.258 136.948 1.00 107.93 ? 312 TYR A CB  1 
ATOM 1979 C CG  . TYR A 1 391 ? 171.418 164.998 136.763 1.00 111.15 ? 312 TYR A CG  1 
ATOM 1980 C CD1 . TYR A 1 391 ? 172.296 164.866 135.695 1.00 117.00 ? 312 TYR A CD1 1 
ATOM 1981 C CD2 . TYR A 1 391 ? 171.318 163.943 137.664 1.00 106.51 ? 312 TYR A CD2 1 
ATOM 1982 C CE1 . TYR A 1 391 ? 173.044 163.716 135.522 1.00 116.41 ? 312 TYR A CE1 1 
ATOM 1983 C CE2 . TYR A 1 391 ? 172.062 162.790 137.500 1.00 109.34 ? 312 TYR A CE2 1 
ATOM 1984 C CZ  . TYR A 1 391 ? 172.924 162.683 136.428 1.00 114.67 ? 312 TYR A CZ  1 
ATOM 1985 O OH  . TYR A 1 391 ? 173.668 161.538 136.260 1.00 115.65 ? 312 TYR A OH  1 
ATOM 1986 N N   . VAL A 1 392 ? 167.584 165.065 136.954 1.00 98.00  ? 313 VAL A N   1 
ATOM 1987 C CA  . VAL A 1 392 ? 166.751 163.881 137.122 1.00 93.84  ? 313 VAL A CA  1 
ATOM 1988 C C   . VAL A 1 392 ? 165.310 164.222 136.774 1.00 90.68  ? 313 VAL A C   1 
ATOM 1989 O O   . VAL A 1 392 ? 164.375 163.671 137.362 1.00 87.76  ? 313 VAL A O   1 
ATOM 1990 C CB  . VAL A 1 392 ? 166.850 163.331 138.556 1.00 92.35  ? 313 VAL A CB  1 
ATOM 1991 C CG1 . VAL A 1 392 ? 168.090 162.466 138.711 1.00 94.84  ? 313 VAL A CG1 1 
ATOM 1992 C CG2 . VAL A 1 392 ? 166.866 164.475 139.550 1.00 95.41  ? 313 VAL A CG2 1 
ATOM 1993 N N   . ARG A 1 393 ? 165.125 165.148 135.828 1.00 94.38  ? 314 ARG A N   1 
ATOM 1994 C CA  . ARG A 1 393 ? 163.778 165.573 135.455 1.00 93.45  ? 314 ARG A CA  1 
ATOM 1995 C C   . ARG A 1 393 ? 162.993 164.439 134.805 1.00 88.93  ? 314 ARG A C   1 
ATOM 1996 O O   . ARG A 1 393 ? 161.825 164.218 135.141 1.00 85.11  ? 314 ARG A O   1 
ATOM 1997 C CB  . ARG A 1 393 ? 163.854 166.782 134.520 1.00 96.49  ? 314 ARG A CB  1 
ATOM 1998 C CG  . ARG A 1 393 ? 162.515 167.265 133.966 1.00 96.40  ? 314 ARG A CG  1 
ATOM 1999 C CD  . ARG A 1 393 ? 161.477 167.530 135.066 1.00 99.98  ? 314 ARG A CD  1 
ATOM 2000 N NE  . ARG A 1 393 ? 161.955 168.384 136.151 1.00 103.41 ? 314 ARG A NE  1 
ATOM 2001 C CZ  . ARG A 1 393 ? 162.283 169.666 136.041 1.00 104.93 ? 314 ARG A CZ  1 
ATOM 2002 N NH1 . ARG A 1 393 ? 162.131 170.332 134.907 1.00 101.80 ? 314 ARG A NH1 1 
ATOM 2003 N NH2 . ARG A 1 393 ? 162.752 170.307 137.108 1.00 104.82 ? 314 ARG A NH2 1 
ATOM 2004 N N   . TRP A 1 394 ? 163.617 163.698 133.888 1.00 90.31  ? 315 TRP A N   1 
ATOM 2005 C CA  . TRP A 1 394 ? 162.909 162.632 133.190 1.00 88.43  ? 315 TRP A CA  1 
ATOM 2006 C C   . TRP A 1 394 ? 162.804 161.350 134.005 1.00 84.39  ? 315 TRP A C   1 
ATOM 2007 O O   . TRP A 1 394 ? 161.970 160.498 133.682 1.00 81.24  ? 315 TRP A O   1 
ATOM 2008 C CB  . TRP A 1 394 ? 163.579 162.351 131.844 1.00 89.62  ? 315 TRP A CB  1 
ATOM 2009 C CG  . TRP A 1 394 ? 163.147 163.303 130.768 1.00 93.20  ? 315 TRP A CG  1 
ATOM 2010 C CD1 . TRP A 1 394 ? 163.921 164.227 130.136 1.00 97.78  ? 315 TRP A CD1 1 
ATOM 2011 C CD2 . TRP A 1 394 ? 161.843 163.404 130.182 1.00 89.67  ? 315 TRP A CD2 1 
ATOM 2012 N NE1 . TRP A 1 394 ? 163.179 164.913 129.206 1.00 98.26  ? 315 TRP A NE1 1 
ATOM 2013 C CE2 . TRP A 1 394 ? 161.901 164.423 129.211 1.00 94.43  ? 315 TRP A CE2 1 
ATOM 2014 C CE3 . TRP A 1 394 ? 160.633 162.736 130.385 1.00 86.00  ? 315 TRP A CE3 1 
ATOM 2015 C CZ2 . TRP A 1 394 ? 160.795 164.789 128.448 1.00 97.03  ? 315 TRP A CZ2 1 
ATOM 2016 C CZ3 . TRP A 1 394 ? 159.537 163.102 129.628 1.00 88.45  ? 315 TRP A CZ3 1 
ATOM 2017 C CH2 . TRP A 1 394 ? 159.625 164.119 128.671 1.00 95.35  ? 315 TRP A CH2 1 
ATOM 2018 N N   . GLN A 1 395 ? 163.618 161.191 135.049 1.00 82.83  ? 316 GLN A N   1 
ATOM 2019 C CA  . GLN A 1 395 ? 163.460 160.040 135.930 1.00 76.26  ? 316 GLN A CA  1 
ATOM 2020 C C   . GLN A 1 395 ? 162.282 160.205 136.881 1.00 76.21  ? 316 GLN A C   1 
ATOM 2021 O O   . GLN A 1 395 ? 161.644 159.211 137.242 1.00 77.42  ? 316 GLN A O   1 
ATOM 2022 C CB  . GLN A 1 395 ? 164.743 159.796 136.724 1.00 74.55  ? 316 GLN A CB  1 
ATOM 2023 C CG  . GLN A 1 395 ? 165.831 159.095 135.936 1.00 77.37  ? 316 GLN A CG  1 
ATOM 2024 C CD  . GLN A 1 395 ? 167.216 159.593 136.282 1.00 83.31  ? 316 GLN A CD  1 
ATOM 2025 O OE1 . GLN A 1 395 ? 167.589 160.713 135.934 1.00 87.28  ? 316 GLN A OE1 1 
ATOM 2026 N NE2 . GLN A 1 395 ? 167.989 158.763 136.972 1.00 82.97  ? 316 GLN A NE2 1 
ATOM 2027 N N   . VAL A 1 396 ? 161.988 161.438 137.298 1.00 76.78  ? 317 VAL A N   1 
ATOM 2028 C CA  . VAL A 1 396 ? 160.896 161.672 138.240 1.00 74.69  ? 317 VAL A CA  1 
ATOM 2029 C C   . VAL A 1 396 ? 159.545 161.438 137.571 1.00 74.76  ? 317 VAL A C   1 
ATOM 2030 O O   . VAL A 1 396 ? 158.668 160.771 138.132 1.00 74.33  ? 317 VAL A O   1 
ATOM 2031 C CB  . VAL A 1 396 ? 161.003 163.086 138.840 1.00 72.37  ? 317 VAL A CB  1 
ATOM 2032 C CG1 . VAL A 1 396 ? 159.756 163.436 139.627 1.00 72.70  ? 317 VAL A CG1 1 
ATOM 2033 C CG2 . VAL A 1 396 ? 162.216 163.177 139.746 1.00 77.10  ? 317 VAL A CG2 1 
ATOM 2034 N N   . VAL A 1 397 ? 159.361 161.968 136.357 1.00 73.67  ? 318 VAL A N   1 
ATOM 2035 C CA  . VAL A 1 397 ? 158.090 161.774 135.661 1.00 69.44  ? 318 VAL A CA  1 
ATOM 2036 C C   . VAL A 1 397 ? 157.931 160.327 135.216 1.00 64.98  ? 318 VAL A C   1 
ATOM 2037 O O   . VAL A 1 397 ? 156.805 159.839 135.071 1.00 64.19  ? 318 VAL A O   1 
ATOM 2038 C CB  . VAL A 1 397 ? 157.954 162.737 134.468 1.00 72.42  ? 318 VAL A CB  1 
ATOM 2039 C CG1 . VAL A 1 397 ? 157.493 164.109 134.939 1.00 72.35  ? 318 VAL A CG1 1 
ATOM 2040 C CG2 . VAL A 1 397 ? 159.251 162.829 133.709 1.00 76.26  ? 318 VAL A CG2 1 
ATOM 2041 N N   . THR A 1 398 ? 159.042 159.626 134.973 1.00 67.09  ? 319 THR A N   1 
ATOM 2042 C CA  . THR A 1 398 ? 158.972 158.191 134.712 1.00 69.27  ? 319 THR A CA  1 
ATOM 2043 C C   . THR A 1 398 ? 158.431 157.448 135.926 1.00 65.28  ? 319 THR A C   1 
ATOM 2044 O O   . THR A 1 398 ? 157.631 156.516 135.789 1.00 63.15  ? 319 THR A O   1 
ATOM 2045 C CB  . THR A 1 398 ? 160.352 157.659 134.322 1.00 76.22  ? 319 THR A CB  1 
ATOM 2046 O OG1 . THR A 1 398 ? 160.841 158.386 133.189 1.00 79.65  ? 319 THR A OG1 1 
ATOM 2047 C CG2 . THR A 1 398 ? 160.285 156.180 133.966 1.00 69.52  ? 319 THR A CG2 1 
ATOM 2048 N N   . VAL A 1 399 ? 158.849 157.857 137.125 1.00 66.44  ? 320 VAL A N   1 
ATOM 2049 C CA  . VAL A 1 399 ? 158.310 157.273 138.349 1.00 63.62  ? 320 VAL A CA  1 
ATOM 2050 C C   . VAL A 1 399 ? 156.841 157.647 138.525 1.00 62.94  ? 320 VAL A C   1 
ATOM 2051 O O   . VAL A 1 399 ? 156.010 156.794 138.857 1.00 59.94  ? 320 VAL A O   1 
ATOM 2052 C CB  . VAL A 1 399 ? 159.164 157.704 139.556 1.00 62.93  ? 320 VAL A CB  1 
ATOM 2053 C CG1 . VAL A 1 399 ? 158.477 157.358 140.864 1.00 64.75  ? 320 VAL A CG1 1 
ATOM 2054 C CG2 . VAL A 1 399 ? 160.527 157.045 139.491 1.00 65.12  ? 320 VAL A CG2 1 
ATOM 2055 N N   . ILE A 1 400 ? 156.494 158.916 138.282 1.00 67.46  ? 321 ILE A N   1 
ATOM 2056 C CA  . ILE A 1 400 ? 155.140 159.399 138.557 1.00 64.47  ? 321 ILE A CA  1 
ATOM 2057 C C   . ILE A 1 400 ? 154.124 158.757 137.617 1.00 59.96  ? 321 ILE A C   1 
ATOM 2058 O O   . ILE A 1 400 ? 153.086 158.254 138.061 1.00 54.10  ? 321 ILE A O   1 
ATOM 2059 C CB  . ILE A 1 400 ? 155.089 160.936 138.473 1.00 62.18  ? 321 ILE A CB  1 
ATOM 2060 C CG1 . ILE A 1 400 ? 155.863 161.566 139.630 1.00 64.20  ? 321 ILE A CG1 1 
ATOM 2061 C CG2 . ILE A 1 400 ? 153.654 161.435 138.467 1.00 58.36  ? 321 ILE A CG2 1 
ATOM 2062 C CD1 . ILE A 1 400 ? 156.069 163.051 139.472 1.00 68.48  ? 321 ILE A CD1 1 
ATOM 2063 N N   . VAL A 1 401 ? 154.410 158.758 136.311 1.00 61.78  ? 322 VAL A N   1 
ATOM 2064 C CA  . VAL A 1 401 ? 153.462 158.231 135.328 1.00 58.62  ? 322 VAL A CA  1 
ATOM 2065 C C   . VAL A 1 401 ? 153.273 156.728 135.509 1.00 58.33  ? 322 VAL A C   1 
ATOM 2066 O O   . VAL A 1 401 ? 152.149 156.216 135.421 1.00 60.68  ? 322 VAL A O   1 
ATOM 2067 C CB  . VAL A 1 401 ? 153.923 158.589 133.902 1.00 58.97  ? 322 VAL A CB  1 
ATOM 2068 C CG1 . VAL A 1 401 ? 153.072 157.890 132.856 1.00 54.05  ? 322 VAL A CG1 1 
ATOM 2069 C CG2 . VAL A 1 401 ? 153.851 160.093 133.694 1.00 65.77  ? 322 VAL A CG2 1 
ATOM 2070 N N   . THR A 1 402 ? 154.360 156.003 135.781 1.00 57.31  ? 323 THR A N   1 
ATOM 2071 C CA  . THR A 1 402 ? 154.257 154.572 136.053 1.00 53.63  ? 323 THR A CA  1 
ATOM 2072 C C   . THR A 1 402 ? 153.463 154.307 137.329 1.00 55.97  ? 323 THR A C   1 
ATOM 2073 O O   . THR A 1 402 ? 152.588 153.432 137.353 1.00 55.70  ? 323 THR A O   1 
ATOM 2074 C CB  . THR A 1 402 ? 155.661 153.968 136.139 1.00 54.07  ? 323 THR A CB  1 
ATOM 2075 O OG1 . THR A 1 402 ? 156.157 153.737 134.817 1.00 59.41  ? 323 THR A OG1 1 
ATOM 2076 C CG2 . THR A 1 402 ? 155.663 152.660 136.890 1.00 52.53  ? 323 THR A CG2 1 
ATOM 2077 N N   . MET A 1 403 ? 153.730 155.077 138.388 1.00 57.12  ? 324 MET A N   1 
ATOM 2078 C CA  . MET A 1 403 ? 153.002 154.901 139.643 1.00 55.43  ? 324 MET A CA  1 
ATOM 2079 C C   . MET A 1 403 ? 151.544 155.320 139.506 1.00 53.96  ? 324 MET A C   1 
ATOM 2080 O O   . MET A 1 403 ? 150.660 154.703 140.112 1.00 53.54  ? 324 MET A O   1 
ATOM 2081 C CB  . MET A 1 403 ? 153.678 155.692 140.760 1.00 53.51  ? 324 MET A CB  1 
ATOM 2082 C CG  . MET A 1 403 ? 155.060 155.195 141.130 1.00 55.84  ? 324 MET A CG  1 
ATOM 2083 S SD  . MET A 1 403 ? 155.068 153.490 141.702 1.00 64.18  ? 324 MET A SD  1 
ATOM 2084 C CE  . MET A 1 403 ? 154.164 153.661 143.237 1.00 64.83  ? 324 MET A CE  1 
ATOM 2085 N N   . ALA A 1 404 ? 151.275 156.381 138.738 1.00 52.04  ? 325 ALA A N   1 
ATOM 2086 C CA  . ALA A 1 404 ? 149.894 156.789 138.496 1.00 48.09  ? 325 ALA A CA  1 
ATOM 2087 C C   . ALA A 1 404 ? 149.143 155.732 137.697 1.00 48.36  ? 325 ALA A C   1 
ATOM 2088 O O   . ALA A 1 404 ? 148.018 155.361 138.046 1.00 49.84  ? 325 ALA A O   1 
ATOM 2089 C CB  . ALA A 1 404 ? 149.854 158.135 137.774 1.00 47.08  ? 325 ALA A CB  1 
ATOM 2090 N N   . CYS A 1 405 ? 149.764 155.211 136.636 1.00 47.44  ? 326 CYS A N   1 
ATOM 2091 C CA  . CYS A 1 405 ? 149.137 154.150 135.859 1.00 45.22  ? 326 CYS A CA  1 
ATOM 2092 C C   . CYS A 1 405 ? 149.102 152.828 136.609 1.00 47.36  ? 326 CYS A C   1 
ATOM 2093 O O   . CYS A 1 405 ? 148.348 151.933 136.219 1.00 47.55  ? 326 CYS A O   1 
ATOM 2094 C CB  . CYS A 1 405 ? 149.861 153.962 134.526 1.00 46.92  ? 326 CYS A CB  1 
ATOM 2095 S SG  . CYS A 1 405 ? 149.667 155.331 133.366 1.00 64.82  ? 326 CYS A SG  1 
ATOM 2096 N N   . TYR A 1 406 ? 149.904 152.683 137.666 1.00 49.39  ? 327 TYR A N   1 
ATOM 2097 C CA  . TYR A 1 406 ? 149.849 151.476 138.484 1.00 51.52  ? 327 TYR A CA  1 
ATOM 2098 C C   . TYR A 1 406 ? 148.508 151.357 139.199 1.00 54.49  ? 327 TYR A C   1 
ATOM 2099 O O   . TYR A 1 406 ? 147.980 150.251 139.356 1.00 54.87  ? 327 TYR A O   1 
ATOM 2100 C CB  . TYR A 1 406 ? 151.009 151.478 139.481 1.00 54.06  ? 327 TYR A CB  1 
ATOM 2101 C CG  . TYR A 1 406 ? 150.974 150.373 140.511 1.00 55.94  ? 327 TYR A CG  1 
ATOM 2102 C CD1 . TYR A 1 406 ? 151.405 149.093 140.194 1.00 57.08  ? 327 TYR A CD1 1 
ATOM 2103 C CD2 . TYR A 1 406 ? 150.549 150.618 141.811 1.00 54.08  ? 327 TYR A CD2 1 
ATOM 2104 C CE1 . TYR A 1 406 ? 151.388 148.084 141.132 1.00 57.09  ? 327 TYR A CE1 1 
ATOM 2105 C CE2 . TYR A 1 406 ? 150.529 149.611 142.755 1.00 57.16  ? 327 TYR A CE2 1 
ATOM 2106 C CZ  . TYR A 1 406 ? 150.950 148.347 142.410 1.00 57.54  ? 327 TYR A CZ  1 
ATOM 2107 O OH  . TYR A 1 406 ? 150.934 147.340 143.347 1.00 60.25  ? 327 TYR A OH  1 
ATOM 2108 N N   . GLN A 1 407 ? 147.940 152.486 139.629 1.00 50.76  ? 328 GLN A N   1 
ATOM 2109 C CA  . GLN A 1 407 ? 146.637 152.526 140.284 1.00 47.06  ? 328 GLN A CA  1 
ATOM 2110 C C   . GLN A 1 407 ? 145.500 152.865 139.334 1.00 44.43  ? 328 GLN A C   1 
ATOM 2111 O O   . GLN A 1 407 ? 144.415 152.287 139.447 1.00 42.25  ? 328 GLN A O   1 
ATOM 2112 C CB  . GLN A 1 407 ? 146.646 153.542 141.434 1.00 45.70  ? 328 GLN A CB  1 
ATOM 2113 C CG  . GLN A 1 407 ? 147.532 153.235 142.673 1.00 46.17  ? 328 GLN A CG  1 
ATOM 2114 C CD  . GLN A 1 407 ? 147.454 151.813 143.279 1.00 52.54  ? 328 GLN A CD  1 
ATOM 2115 O OE1 . GLN A 1 407 ? 146.596 150.997 142.946 1.00 55.26  ? 328 GLN A OE1 1 
ATOM 2116 N NE2 . GLN A 1 407 ? 148.365 151.542 144.206 1.00 52.75  ? 328 GLN A NE2 1 
ATOM 2117 N N   . LEU A 1 408 ? 145.723 153.785 138.394 1.00 42.98  ? 329 LEU A N   1 
ATOM 2118 C CA  . LEU A 1 408 ? 144.679 154.177 137.455 1.00 39.28  ? 329 LEU A CA  1 
ATOM 2119 C C   . LEU A 1 408 ? 144.413 153.128 136.384 1.00 40.46  ? 329 LEU A C   1 
ATOM 2120 O O   . LEU A 1 408 ? 143.502 153.324 135.573 1.00 39.67  ? 329 LEU A O   1 
ATOM 2121 C CB  . LEU A 1 408 ? 145.029 155.508 136.788 1.00 38.61  ? 329 LEU A CB  1 
ATOM 2122 C CG  . LEU A 1 408 ? 145.057 156.753 137.677 1.00 35.61  ? 329 LEU A CG  1 
ATOM 2123 C CD1 . LEU A 1 408 ? 145.715 157.911 136.955 1.00 37.53  ? 329 LEU A CD1 1 
ATOM 2124 C CD2 . LEU A 1 408 ? 143.658 157.135 138.107 1.00 33.72  ? 329 LEU A CD2 1 
ATOM 2125 N N   . CYS A 1 409 ? 145.185 152.036 136.347 1.00 42.03  ? 330 CYS A N   1 
ATOM 2126 C CA  . CYS A 1 409 ? 144.850 150.922 135.467 1.00 42.20  ? 330 CYS A CA  1 
ATOM 2127 C C   . CYS A 1 409 ? 143.528 150.274 135.849 1.00 45.08  ? 330 CYS A C   1 
ATOM 2128 O O   . CYS A 1 409 ? 142.880 149.665 134.992 1.00 50.36  ? 330 CYS A O   1 
ATOM 2129 C CB  . CYS A 1 409 ? 145.962 149.873 135.482 1.00 42.96  ? 330 CYS A CB  1 
ATOM 2130 S SG  . CYS A 1 409 ? 146.105 148.943 137.021 1.00 59.49  ? 330 CYS A SG  1 
ATOM 2131 N N   . GLY A 1 410 ? 143.106 150.402 137.102 1.00 39.69  ? 331 GLY A N   1 
ATOM 2132 C CA  . GLY A 1 410 ? 141.791 149.970 137.514 1.00 36.76  ? 331 GLY A CA  1 
ATOM 2133 C C   . GLY A 1 410 ? 141.707 148.618 138.174 1.00 38.49  ? 331 GLY A C   1 
ATOM 2134 O O   . GLY A 1 410 ? 140.597 148.088 138.303 1.00 43.89  ? 331 GLY A O   1 
ATOM 2135 N N   . LEU A 1 411 ? 142.835 148.031 138.577 1.00 39.14  ? 332 LEU A N   1 
ATOM 2136 C CA  . LEU A 1 411 ? 142.775 146.773 139.312 1.00 40.68  ? 332 LEU A CA  1 
ATOM 2137 C C   . LEU A 1 411 ? 142.112 146.963 140.669 1.00 40.37  ? 332 LEU A C   1 
ATOM 2138 O O   . LEU A 1 411 ? 141.356 146.098 141.122 1.00 41.99  ? 332 LEU A O   1 
ATOM 2139 C CB  . LEU A 1 411 ? 144.169 146.181 139.488 1.00 42.00  ? 332 LEU A CB  1 
ATOM 2140 C CG  . LEU A 1 411 ? 144.084 144.740 139.994 1.00 42.00  ? 332 LEU A CG  1 
ATOM 2141 C CD1 . LEU A 1 411 ? 143.685 143.795 138.870 1.00 39.65  ? 332 LEU A CD1 1 
ATOM 2142 C CD2 . LEU A 1 411 ? 145.350 144.293 140.679 1.00 47.59  ? 332 LEU A CD2 1 
ATOM 2143 N N   . ASN A 1 412 ? 142.382 148.089 141.332 1.00 37.82  ? 333 ASN A N   1 
ATOM 2144 C CA  . ASN A 1 412 ? 141.741 148.357 142.614 1.00 36.58  ? 333 ASN A CA  1 
ATOM 2145 C C   . ASN A 1 412 ? 140.245 148.596 142.455 1.00 36.45  ? 333 ASN A C   1 
ATOM 2146 O O   . ASN A 1 412 ? 139.476 148.305 143.376 1.00 36.66  ? 333 ASN A O   1 
ATOM 2147 C CB  . ASN A 1 412 ? 142.405 149.548 143.298 1.00 36.94  ? 333 ASN A CB  1 
ATOM 2148 C CG  . ASN A 1 412 ? 143.327 149.127 144.419 1.00 38.34  ? 333 ASN A CG  1 
ATOM 2149 O OD1 . ASN A 1 412 ? 143.803 147.994 144.452 1.00 43.16  ? 333 ASN A OD1 1 
ATOM 2150 N ND2 . ASN A 1 412 ? 143.577 150.034 145.352 1.00 39.10  ? 333 ASN A ND2 1 
ATOM 2151 N N   . ALA A 1 413 ? 139.815 149.108 141.298 1.00 35.88  ? 334 ALA A N   1 
ATOM 2152 C CA  . ALA A 1 413 ? 138.387 149.233 141.027 1.00 32.46  ? 334 ALA A CA  1 
ATOM 2153 C C   . ALA A 1 413 ? 137.712 147.874 140.940 1.00 32.42  ? 334 ALA A C   1 
ATOM 2154 O O   . ALA A 1 413 ? 136.515 147.757 141.225 1.00 34.61  ? 334 ALA A O   1 
ATOM 2155 C CB  . ALA A 1 413 ? 138.154 150.009 139.733 1.00 32.90  ? 334 ALA A CB  1 
ATOM 2156 N N   . ILE A 1 414 ? 138.453 146.845 140.527 1.00 31.41  ? 335 ILE A N   1 
ATOM 2157 C CA  . ILE A 1 414 ? 137.909 145.493 140.521 1.00 31.74  ? 335 ILE A CA  1 
ATOM 2158 C C   . ILE A 1 414 ? 137.634 145.026 141.945 1.00 35.15  ? 335 ILE A C   1 
ATOM 2159 O O   . ILE A 1 414 ? 136.560 144.495 142.238 1.00 38.63  ? 335 ILE A O   1 
ATOM 2160 C CB  . ILE A 1 414 ? 138.858 144.532 139.780 1.00 30.22  ? 335 ILE A CB  1 
ATOM 2161 C CG1 . ILE A 1 414 ? 138.922 144.885 138.295 1.00 30.57  ? 335 ILE A CG1 1 
ATOM 2162 C CG2 . ILE A 1 414 ? 138.422 143.089 139.960 1.00 32.82  ? 335 ILE A CG2 1 
ATOM 2163 C CD1 . ILE A 1 414 ? 140.003 144.145 137.543 1.00 33.38  ? 335 ILE A CD1 1 
ATOM 2164 N N   . TRP A 1 415 ? 138.581 145.251 142.860 1.00 35.07  ? 336 TRP A N   1 
ATOM 2165 C CA  . TRP A 1 415 ? 138.441 144.710 144.210 1.00 33.70  ? 336 TRP A CA  1 
ATOM 2166 C C   . TRP A 1 415 ? 137.338 145.418 144.981 1.00 33.45  ? 336 TRP A C   1 
ATOM 2167 O O   . TRP A 1 415 ? 136.621 144.789 145.767 1.00 36.81  ? 336 TRP A O   1 
ATOM 2168 C CB  . TRP A 1 415 ? 139.763 144.819 144.967 1.00 33.07  ? 336 TRP A CB  1 
ATOM 2169 C CG  . TRP A 1 415 ? 140.943 144.342 144.190 1.00 34.73  ? 336 TRP A CG  1 
ATOM 2170 C CD1 . TRP A 1 415 ? 142.065 145.060 143.917 1.00 37.61  ? 336 TRP A CD1 1 
ATOM 2171 C CD2 . TRP A 1 415 ? 141.112 143.071 143.542 1.00 37.85  ? 336 TRP A CD2 1 
ATOM 2172 N NE1 . TRP A 1 415 ? 142.932 144.318 143.160 1.00 43.57  ? 336 TRP A NE1 1 
ATOM 2173 C CE2 . TRP A 1 415 ? 142.370 143.093 142.915 1.00 40.74  ? 336 TRP A CE2 1 
ATOM 2174 C CE3 . TRP A 1 415 ? 140.331 141.913 143.441 1.00 35.96  ? 336 TRP A CE3 1 
ATOM 2175 C CZ2 . TRP A 1 415 ? 142.858 142.017 142.191 1.00 38.63  ? 336 TRP A CZ2 1 
ATOM 2176 C CZ3 . TRP A 1 415 ? 140.821 140.844 142.727 1.00 38.77  ? 336 TRP A CZ3 1 
ATOM 2177 C CH2 . TRP A 1 415 ? 142.075 140.899 142.116 1.00 41.82  ? 336 TRP A CH2 1 
ATOM 2178 N N   . PHE A 1 416 ? 137.190 146.726 144.773 1.00 31.93  ? 337 PHE A N   1 
ATOM 2179 C CA  . PHE A 1 416 ? 136.179 147.480 145.500 1.00 32.17  ? 337 PHE A CA  1 
ATOM 2180 C C   . PHE A 1 416 ? 134.772 147.196 144.987 1.00 31.62  ? 337 PHE A C   1 
ATOM 2181 O O   . PHE A 1 416 ? 133.813 147.250 145.765 1.00 32.39  ? 337 PHE A O   1 
ATOM 2182 C CB  . PHE A 1 416 ? 136.468 148.976 145.404 1.00 34.75  ? 337 PHE A CB  1 
ATOM 2183 C CG  . PHE A 1 416 ? 137.794 149.389 145.970 1.00 33.21  ? 337 PHE A CG  1 
ATOM 2184 C CD1 . PHE A 1 416 ? 138.319 148.757 147.079 1.00 34.44  ? 337 PHE A CD1 1 
ATOM 2185 C CD2 . PHE A 1 416 ? 138.498 150.442 145.407 1.00 29.17  ? 337 PHE A CD2 1 
ATOM 2186 C CE1 . PHE A 1 416 ? 139.533 149.147 147.604 1.00 36.33  ? 337 PHE A CE1 1 
ATOM 2187 C CE2 . PHE A 1 416 ? 139.713 150.837 145.926 1.00 32.66  ? 337 PHE A CE2 1 
ATOM 2188 C CZ  . PHE A 1 416 ? 140.231 150.189 147.028 1.00 35.98  ? 337 PHE A CZ  1 
ATOM 2189 N N   . TYR A 1 417 ? 134.618 146.920 143.694 1.00 30.22  ? 338 TYR A N   1 
ATOM 2190 C CA  . TYR A 1 417 ? 133.301 146.784 143.074 1.00 31.14  ? 338 TYR A CA  1 
ATOM 2191 C C   . TYR A 1 417 ? 133.245 145.569 142.160 1.00 31.64  ? 338 TYR A C   1 
ATOM 2192 O O   . TYR A 1 417 ? 132.842 145.665 141.001 1.00 33.36  ? 338 TYR A O   1 
ATOM 2193 C CB  . TYR A 1 417 ? 132.902 148.021 142.269 1.00 31.73  ? 338 TYR A CB  1 
ATOM 2194 C CG  . TYR A 1 417 ? 133.250 149.354 142.889 1.00 31.12  ? 338 TYR A CG  1 
ATOM 2195 C CD1 . TYR A 1 417 ? 134.481 149.952 142.656 1.00 29.22  ? 338 TYR A CD1 1 
ATOM 2196 C CD2 . TYR A 1 417 ? 132.350 150.011 143.714 1.00 33.25  ? 338 TYR A CD2 1 
ATOM 2197 C CE1 . TYR A 1 417 ? 134.798 151.171 143.214 1.00 29.72  ? 338 TYR A CE1 1 
ATOM 2198 C CE2 . TYR A 1 417 ? 132.663 151.225 144.285 1.00 31.56  ? 338 TYR A CE2 1 
ATOM 2199 C CZ  . TYR A 1 417 ? 133.888 151.800 144.031 1.00 30.81  ? 338 TYR A CZ  1 
ATOM 2200 O OH  . TYR A 1 417 ? 134.206 153.012 144.595 1.00 37.21  ? 338 TYR A OH  1 
ATOM 2201 N N   . THR A 1 418 ? 133.657 144.401 142.659 1.00 32.00  ? 339 THR A N   1 
ATOM 2202 C CA  . THR A 1 418 ? 133.626 143.200 141.826 1.00 29.27  ? 339 THR A CA  1 
ATOM 2203 C C   . THR A 1 418 ? 132.193 142.753 141.554 1.00 34.65  ? 339 THR A C   1 
ATOM 2204 O O   . THR A 1 418 ? 131.829 142.469 140.406 1.00 41.15  ? 339 THR A O   1 
ATOM 2205 C CB  . THR A 1 418 ? 134.420 142.075 142.487 1.00 30.54  ? 339 THR A CB  1 
ATOM 2206 O OG1 . THR A 1 418 ? 135.812 142.403 142.470 1.00 31.66  ? 339 THR A OG1 1 
ATOM 2207 C CG2 . THR A 1 418 ? 134.249 140.800 141.714 1.00 33.89  ? 339 THR A CG2 1 
ATOM 2208 N N   . ASN A 1 419 ? 131.360 142.702 142.597 1.00 33.32  ? 340 ASN A N   1 
ATOM 2209 C CA  . ASN A 1 419 ? 129.965 142.314 142.416 1.00 33.29  ? 340 ASN A CA  1 
ATOM 2210 C C   . ASN A 1 419 ? 129.194 143.343 141.598 1.00 33.90  ? 340 ASN A C   1 
ATOM 2211 O O   . ASN A 1 419 ? 128.192 143.001 140.961 1.00 36.12  ? 340 ASN A O   1 
ATOM 2212 C CB  . ASN A 1 419 ? 129.295 142.106 143.774 1.00 34.27  ? 340 ASN A CB  1 
ATOM 2213 C CG  . ASN A 1 419 ? 129.746 140.830 144.457 1.00 32.41  ? 340 ASN A CG  1 
ATOM 2214 O OD1 . ASN A 1 419 ? 130.682 140.171 144.010 1.00 34.70  ? 340 ASN A OD1 1 
ATOM 2215 N ND2 . ASN A 1 419 ? 129.079 140.476 145.548 1.00 30.61  ? 340 ASN A ND2 1 
ATOM 2216 N N   . SER A 1 420 ? 129.638 144.602 141.611 1.00 32.35  ? 341 SER A N   1 
ATOM 2217 C CA  . SER A 1 420 ? 129.024 145.613 140.758 1.00 33.54  ? 341 SER A CA  1 
ATOM 2218 C C   . SER A 1 420 ? 129.345 145.369 139.288 1.00 38.73  ? 341 SER A C   1 
ATOM 2219 O O   . SER A 1 420 ? 128.489 145.575 138.420 1.00 43.69  ? 341 SER A O   1 
ATOM 2220 C CB  . SER A 1 420 ? 129.485 147.005 141.186 1.00 32.53  ? 341 SER A CB  1 
ATOM 2221 O OG  . SER A 1 420 ? 128.926 148.005 140.354 1.00 40.63  ? 341 SER A OG  1 
ATOM 2222 N N   . ILE A 1 421 ? 130.576 144.946 138.989 1.00 37.56  ? 342 ILE A N   1 
ATOM 2223 C CA  . ILE A 1 421 ? 130.952 144.653 137.609 1.00 33.62  ? 342 ILE A CA  1 
ATOM 2224 C C   . ILE A 1 421 ? 130.227 143.410 137.108 1.00 38.78  ? 342 ILE A C   1 
ATOM 2225 O O   . ILE A 1 421 ? 129.622 143.418 136.030 1.00 42.90  ? 342 ILE A O   1 
ATOM 2226 C CB  . ILE A 1 421 ? 132.479 144.499 137.489 1.00 30.57  ? 342 ILE A CB  1 
ATOM 2227 C CG1 . ILE A 1 421 ? 133.180 145.822 137.794 1.00 31.50  ? 342 ILE A CG1 1 
ATOM 2228 C CG2 . ILE A 1 421 ? 132.865 144.005 136.107 1.00 35.61  ? 342 ILE A CG2 1 
ATOM 2229 C CD1 . ILE A 1 421 ? 134.658 145.673 138.063 1.00 31.62  ? 342 ILE A CD1 1 
ATOM 2230 N N   . PHE A 1 422 ? 130.264 142.327 137.891 1.00 38.13  ? 343 PHE A N   1 
ATOM 2231 C CA  . PHE A 1 422 ? 129.607 141.087 137.487 1.00 41.71  ? 343 PHE A CA  1 
ATOM 2232 C C   . PHE A 1 422 ? 128.091 141.215 137.487 1.00 46.45  ? 343 PHE A C   1 
ATOM 2233 O O   . PHE A 1 422 ? 127.418 140.534 136.708 1.00 49.09  ? 343 PHE A O   1 
ATOM 2234 C CB  . PHE A 1 422 ? 130.042 139.941 138.396 1.00 40.46  ? 343 PHE A CB  1 
ATOM 2235 C CG  . PHE A 1 422 ? 131.450 139.493 138.167 1.00 36.93  ? 343 PHE A CG  1 
ATOM 2236 C CD1 . PHE A 1 422 ? 131.996 139.519 136.898 1.00 39.97  ? 343 PHE A CD1 1 
ATOM 2237 C CD2 . PHE A 1 422 ? 132.234 139.057 139.219 1.00 36.49  ? 343 PHE A CD2 1 
ATOM 2238 C CE1 . PHE A 1 422 ? 133.291 139.103 136.680 1.00 40.97  ? 343 PHE A CE1 1 
ATOM 2239 C CE2 . PHE A 1 422 ? 133.536 138.646 139.004 1.00 36.88  ? 343 PHE A CE2 1 
ATOM 2240 C CZ  . PHE A 1 422 ? 134.063 138.670 137.735 1.00 37.62  ? 343 PHE A CZ  1 
ATOM 2241 N N   . GLY A 1 423 ? 127.538 142.065 138.352 1.00 47.07  ? 344 GLY A N   1 
ATOM 2242 C CA  . GLY A 1 423 ? 126.114 142.342 138.286 1.00 47.75  ? 344 GLY A CA  1 
ATOM 2243 C C   . GLY A 1 423 ? 125.711 143.020 136.993 1.00 46.65  ? 344 GLY A C   1 
ATOM 2244 O O   . GLY A 1 423 ? 124.610 142.795 136.485 1.00 52.74  ? 344 GLY A O   1 
ATOM 2245 N N   . LYS A 1 424 ? 126.592 143.853 136.443 1.00 39.90  ? 345 LYS A N   1 
ATOM 2246 C CA  . LYS A 1 424 ? 126.336 144.519 135.176 1.00 46.33  ? 345 LYS A CA  1 
ATOM 2247 C C   . LYS A 1 424 ? 126.855 143.741 133.973 1.00 49.47  ? 345 LYS A C   1 
ATOM 2248 O O   . LYS A 1 424 ? 126.538 144.111 132.838 1.00 48.50  ? 345 LYS A O   1 
ATOM 2249 C CB  . LYS A 1 424 ? 126.963 145.917 135.183 1.00 46.39  ? 345 LYS A CB  1 
ATOM 2250 C CG  . LYS A 1 424 ? 126.176 146.944 135.978 1.00 42.03  ? 345 LYS A CG  1 
ATOM 2251 C CD  . LYS A 1 424 ? 126.873 148.293 135.977 1.00 41.40  ? 345 LYS A CD  1 
ATOM 2252 C CE  . LYS A 1 424 ? 126.097 149.319 136.784 1.00 42.66  ? 345 LYS A CE  1 
ATOM 2253 N NZ  . LYS A 1 424 ? 125.243 148.681 137.823 1.00 50.89  ? 345 LYS A NZ  1 
ATOM 2254 N N   . ALA A 1 425 ? 127.646 142.693 134.183 1.00 50.02  ? 346 ALA A N   1 
ATOM 2255 C CA  . ALA A 1 425 ? 128.175 141.902 133.071 1.00 48.47  ? 346 ALA A CA  1 
ATOM 2256 C C   . ALA A 1 425 ? 127.301 140.692 132.765 1.00 48.53  ? 346 ALA A C   1 
ATOM 2257 O O   . ALA A 1 425 ? 127.795 139.574 132.631 1.00 50.99  ? 346 ALA A O   1 
ATOM 2258 C CB  . ALA A 1 425 ? 129.605 141.473 133.374 1.00 44.86  ? 346 ALA A CB  1 
ATOM 2259 N N   . GLY A 1 426 ? 125.991 140.910 132.651 1.00 48.71  ? 347 GLY A N   1 
ATOM 2260 C CA  . GLY A 1 426 ? 125.045 139.881 132.250 1.00 54.01  ? 347 GLY A CA  1 
ATOM 2261 C C   . GLY A 1 426 ? 124.933 138.637 133.115 1.00 54.22  ? 347 GLY A C   1 
ATOM 2262 O O   . GLY A 1 426 ? 124.186 137.714 132.777 1.00 58.29  ? 347 GLY A O   1 
ATOM 2263 N N   . ILE A 1 427 ? 125.662 138.590 134.225 1.00 49.08  ? 348 ILE A N   1 
ATOM 2264 C CA  . ILE A 1 427 ? 125.733 137.398 135.063 1.00 51.07  ? 348 ILE A CA  1 
ATOM 2265 C C   . ILE A 1 427 ? 124.487 137.342 135.938 1.00 57.02  ? 348 ILE A C   1 
ATOM 2266 O O   . ILE A 1 427 ? 124.193 138.310 136.655 1.00 58.83  ? 348 ILE A O   1 
ATOM 2267 C CB  . ILE A 1 427 ? 127.015 137.395 135.909 1.00 50.91  ? 348 ILE A CB  1 
ATOM 2268 C CG1 . ILE A 1 427 ? 128.219 137.041 135.035 1.00 49.35  ? 348 ILE A CG1 1 
ATOM 2269 C CG2 . ILE A 1 427 ? 126.889 136.423 137.075 1.00 48.40  ? 348 ILE A CG2 1 
ATOM 2270 C CD1 . ILE A 1 427 ? 129.433 136.599 135.810 1.00 45.04  ? 348 ILE A CD1 1 
ATOM 2271 N N   . PRO A 1 428 ? 123.711 136.256 135.885 1.00 56.04  ? 349 PRO A N   1 
ATOM 2272 C CA  . PRO A 1 428 ? 122.589 136.119 136.809 1.00 55.66  ? 349 PRO A CA  1 
ATOM 2273 C C   . PRO A 1 428 ? 123.084 135.973 138.235 1.00 57.94  ? 349 PRO A C   1 
ATOM 2274 O O   . PRO A 1 428 ? 124.158 135.396 138.479 1.00 60.54  ? 349 PRO A O   1 
ATOM 2275 C CB  . PRO A 1 428 ? 121.887 134.837 136.323 1.00 57.91  ? 349 PRO A CB  1 
ATOM 2276 C CG  . PRO A 1 428 ? 122.340 134.679 134.902 1.00 58.31  ? 349 PRO A CG  1 
ATOM 2277 C CD  . PRO A 1 428 ? 123.759 135.149 134.918 1.00 54.73  ? 349 PRO A CD  1 
ATOM 2278 N N   . PRO A 1 429 ? 122.330 136.475 139.220 1.00 57.08  ? 350 PRO A N   1 
ATOM 2279 C CA  . PRO A 1 429 ? 122.806 136.450 140.612 1.00 52.20  ? 350 PRO A CA  1 
ATOM 2280 C C   . PRO A 1 429 ? 122.862 135.060 141.232 1.00 51.40  ? 350 PRO A C   1 
ATOM 2281 O O   . PRO A 1 429 ? 122.647 134.052 140.550 1.00 52.47  ? 350 PRO A O   1 
ATOM 2282 C CB  . PRO A 1 429 ? 121.788 137.340 141.341 1.00 56.40  ? 350 PRO A CB  1 
ATOM 2283 C CG  . PRO A 1 429 ? 121.181 138.188 140.266 1.00 57.52  ? 350 PRO A CG  1 
ATOM 2284 C CD  . PRO A 1 429 ? 121.115 137.292 139.073 1.00 58.19  ? 350 PRO A CD  1 
ATOM 2285 N N   . ALA A 1 430 ? 123.198 135.018 142.526 1.00 51.71  ? 351 ALA A N   1 
ATOM 2286 C CA  . ALA A 1 430 ? 123.371 133.847 143.390 1.00 55.62  ? 351 ALA A CA  1 
ATOM 2287 C C   . ALA A 1 430 ? 124.599 133.014 143.038 1.00 54.53  ? 351 ALA A C   1 
ATOM 2288 O O   . ALA A 1 430 ? 124.842 131.993 143.692 1.00 54.24  ? 351 ALA A O   1 
ATOM 2289 C CB  . ALA A 1 430 ? 122.136 132.931 143.427 1.00 56.65  ? 351 ALA A CB  1 
ATOM 2290 N N   . LYS A 1 431 ? 125.382 133.408 142.032 1.00 49.85  ? 352 LYS A N   1 
ATOM 2291 C CA  . LYS A 1 431 ? 126.694 132.828 141.796 1.00 47.36  ? 352 LYS A CA  1 
ATOM 2292 C C   . LYS A 1 431 ? 127.780 133.893 141.724 1.00 43.35  ? 352 LYS A C   1 
ATOM 2293 O O   . LYS A 1 431 ? 128.955 133.549 141.559 1.00 41.89  ? 352 LYS A O   1 
ATOM 2294 C CB  . LYS A 1 431 ? 126.698 131.989 140.508 1.00 49.81  ? 352 LYS A CB  1 
ATOM 2295 C CG  . LYS A 1 431 ? 127.652 130.798 140.542 1.00 47.77  ? 352 LYS A CG  1 
ATOM 2296 C CD  . LYS A 1 431 ? 127.611 130.003 139.251 1.00 47.24  ? 352 LYS A CD  1 
ATOM 2297 C CE  . LYS A 1 431 ? 127.599 128.512 139.536 1.00 50.08  ? 352 LYS A CE  1 
ATOM 2298 N NZ  . LYS A 1 431 ? 126.310 128.078 140.139 1.00 45.41  ? 352 LYS A NZ  1 
ATOM 2299 N N   . ILE A 1 432 ? 127.410 135.173 141.839 1.00 44.45  ? 353 ILE A N   1 
ATOM 2300 C CA  . ILE A 1 432 ? 128.413 136.244 141.855 1.00 37.84  ? 353 ILE A CA  1 
ATOM 2301 C C   . ILE A 1 432 ? 129.418 136.125 142.997 1.00 37.20  ? 353 ILE A C   1 
ATOM 2302 O O   . ILE A 1 432 ? 130.613 136.339 142.748 1.00 37.32  ? 353 ILE A O   1 
ATOM 2303 C CB  . ILE A 1 432 ? 127.722 137.614 141.801 1.00 35.47  ? 353 ILE A CB  1 
ATOM 2304 C CG1 . ILE A 1 432 ? 126.733 137.667 140.639 1.00 42.63  ? 353 ILE A CG1 1 
ATOM 2305 C CG2 . ILE A 1 432 ? 128.737 138.732 141.663 1.00 35.36  ? 353 ILE A CG2 1 
ATOM 2306 C CD1 . ILE A 1 432 ? 125.936 138.947 140.584 1.00 46.70  ? 353 ILE A CD1 1 
ATOM 2307 N N   . PRO A 1 433 ? 129.041 135.809 144.252 1.00 37.17  ? 354 PRO A N   1 
ATOM 2308 C CA  . PRO A 1 433 ? 130.075 135.678 145.300 1.00 35.25  ? 354 PRO A CA  1 
ATOM 2309 C C   . PRO A 1 433 ? 131.095 134.573 145.064 1.00 38.26  ? 354 PRO A C   1 
ATOM 2310 O O   . PRO A 1 433 ? 132.174 134.617 145.667 1.00 38.99  ? 354 PRO A O   1 
ATOM 2311 C CB  . PRO A 1 433 ? 129.253 135.401 146.563 1.00 35.98  ? 354 PRO A CB  1 
ATOM 2312 C CG  . PRO A 1 433 ? 128.006 136.119 146.326 1.00 39.40  ? 354 PRO A CG  1 
ATOM 2313 C CD  . PRO A 1 433 ? 127.702 135.831 144.885 1.00 38.89  ? 354 PRO A CD  1 
ATOM 2314 N N   . TYR A 1 434 ? 130.795 133.586 144.221 1.00 38.17  ? 355 TYR A N   1 
ATOM 2315 C CA  . TYR A 1 434 ? 131.776 132.562 143.885 1.00 37.28  ? 355 TYR A CA  1 
ATOM 2316 C C   . TYR A 1 434 ? 132.590 132.915 142.648 1.00 37.73  ? 355 TYR A C   1 
ATOM 2317 O O   . TYR A 1 434 ? 133.757 132.518 142.553 1.00 38.78  ? 355 TYR A O   1 
ATOM 2318 C CB  . TYR A 1 434 ? 131.083 131.210 143.691 1.00 38.34  ? 355 TYR A CB  1 
ATOM 2319 C CG  . TYR A 1 434 ? 129.969 130.955 144.682 1.00 37.73  ? 355 TYR A CG  1 
ATOM 2320 C CD1 . TYR A 1 434 ? 130.248 130.486 145.958 1.00 33.54  ? 355 TYR A CD1 1 
ATOM 2321 C CD2 . TYR A 1 434 ? 128.641 131.179 144.341 1.00 39.49  ? 355 TYR A CD2 1 
ATOM 2322 C CE1 . TYR A 1 434 ? 129.238 130.255 146.870 1.00 35.39  ? 355 TYR A CE1 1 
ATOM 2323 C CE2 . TYR A 1 434 ? 127.624 130.950 145.246 1.00 40.16  ? 355 TYR A CE2 1 
ATOM 2324 C CZ  . TYR A 1 434 ? 127.929 130.488 146.508 1.00 41.12  ? 355 TYR A CZ  1 
ATOM 2325 O OH  . TYR A 1 434 ? 126.919 130.257 147.411 1.00 49.14  ? 355 TYR A OH  1 
ATOM 2326 N N   . VAL A 1 435 ? 132.004 133.647 141.698 1.00 36.84  ? 356 VAL A N   1 
ATOM 2327 C CA  . VAL A 1 435 ? 132.785 134.178 140.585 1.00 33.79  ? 356 VAL A CA  1 
ATOM 2328 C C   . VAL A 1 435 ? 133.735 135.263 141.082 1.00 37.45  ? 356 VAL A C   1 
ATOM 2329 O O   . VAL A 1 435 ? 134.871 135.380 140.606 1.00 41.19  ? 356 VAL A O   1 
ATOM 2330 C CB  . VAL A 1 435 ? 131.843 134.686 139.475 1.00 33.07  ? 356 VAL A CB  1 
ATOM 2331 C CG1 . VAL A 1 435 ? 132.624 135.290 138.331 1.00 32.00  ? 356 VAL A CG1 1 
ATOM 2332 C CG2 . VAL A 1 435 ? 130.976 133.551 138.963 1.00 38.30  ? 356 VAL A CG2 1 
ATOM 2333 N N   . THR A 1 436 ? 133.283 136.063 142.056 1.00 35.75  ? 357 THR A N   1 
ATOM 2334 C CA  . THR A 1 436 ? 134.157 137.009 142.752 1.00 30.82  ? 357 THR A CA  1 
ATOM 2335 C C   . THR A 1 436 ? 135.346 136.302 143.389 1.00 33.60  ? 357 THR A C   1 
ATOM 2336 O O   . THR A 1 436 ? 136.476 136.806 143.346 1.00 31.90  ? 357 THR A O   1 
ATOM 2337 C CB  . THR A 1 436 ? 133.352 137.759 143.816 1.00 36.11  ? 357 THR A CB  1 
ATOM 2338 O OG1 . THR A 1 436 ? 132.307 138.514 143.189 1.00 37.18  ? 357 THR A OG1 1 
ATOM 2339 C CG2 . THR A 1 436 ? 134.233 138.677 144.658 1.00 36.21  ? 357 THR A CG2 1 
ATOM 2340 N N   . LEU A 1 437 ? 135.114 135.116 143.957 1.00 36.65  ? 358 LEU A N   1 
ATOM 2341 C CA  . LEU A 1 437 ? 136.184 134.337 144.569 1.00 36.48  ? 358 LEU A CA  1 
ATOM 2342 C C   . LEU A 1 437 ? 137.230 133.887 143.555 1.00 40.53  ? 358 LEU A C   1 
ATOM 2343 O O   . LEU A 1 437 ? 138.373 133.617 143.940 1.00 42.14  ? 358 LEU A O   1 
ATOM 2344 C CB  . LEU A 1 437 ? 135.588 133.123 145.284 1.00 32.55  ? 358 LEU A CB  1 
ATOM 2345 C CG  . LEU A 1 437 ? 136.404 132.498 146.414 1.00 34.83  ? 358 LEU A CG  1 
ATOM 2346 C CD1 . LEU A 1 437 ? 136.985 133.583 147.296 1.00 32.98  ? 358 LEU A CD1 1 
ATOM 2347 C CD2 . LEU A 1 437 ? 135.546 131.545 147.228 1.00 37.22  ? 358 LEU A CD2 1 
ATOM 2348 N N   . SER A 1 438 ? 136.870 133.803 142.273 1.00 37.23  ? 359 SER A N   1 
ATOM 2349 C CA  . SER A 1 438 ? 137.839 133.445 141.245 1.00 35.16  ? 359 SER A CA  1 
ATOM 2350 C C   . SER A 1 438 ? 138.769 134.600 140.898 1.00 36.53  ? 359 SER A C   1 
ATOM 2351 O O   . SER A 1 438 ? 139.918 134.360 140.510 1.00 39.47  ? 359 SER A O   1 
ATOM 2352 C CB  . SER A 1 438 ? 137.119 132.964 139.986 1.00 36.84  ? 359 SER A CB  1 
ATOM 2353 O OG  . SER A 1 438 ? 136.358 134.009 139.410 1.00 40.21  ? 359 SER A OG  1 
ATOM 2354 N N   . THR A 1 439 ? 138.291 135.844 141.006 1.00 37.27  ? 360 THR A N   1 
ATOM 2355 C CA  . THR A 1 439 ? 139.125 136.999 140.678 1.00 38.80  ? 360 THR A CA  1 
ATOM 2356 C C   . THR A 1 439 ? 140.296 137.138 141.642 1.00 44.15  ? 360 THR A C   1 
ATOM 2357 O O   . THR A 1 439 ? 141.424 137.422 141.224 1.00 47.73  ? 360 THR A O   1 
ATOM 2358 C CB  . THR A 1 439 ? 138.287 138.277 140.680 1.00 36.13  ? 360 THR A CB  1 
ATOM 2359 O OG1 . THR A 1 439 ? 137.633 138.418 141.947 1.00 42.12  ? 360 THR A OG1 1 
ATOM 2360 C CG2 . THR A 1 439 ? 137.248 138.240 139.572 1.00 35.52  ? 360 THR A CG2 1 
ATOM 2361 N N   . GLY A 1 440 ? 140.049 136.958 142.940 1.00 41.68  ? 361 GLY A N   1 
ATOM 2362 C CA  . GLY A 1 440 ? 141.138 136.971 143.897 1.00 40.12  ? 361 GLY A CA  1 
ATOM 2363 C C   . GLY A 1 440 ? 141.938 135.690 143.945 1.00 44.85  ? 361 GLY A C   1 
ATOM 2364 O O   . GLY A 1 440 ? 143.082 135.706 144.407 1.00 50.86  ? 361 GLY A O   1 
ATOM 2365 N N   . GLY A 1 441 ? 141.354 134.581 143.488 1.00 42.96  ? 362 GLY A N   1 
ATOM 2366 C CA  . GLY A 1 441 ? 142.057 133.309 143.533 1.00 46.54  ? 362 GLY A CA  1 
ATOM 2367 C C   . GLY A 1 441 ? 143.230 133.234 142.574 1.00 49.67  ? 362 GLY A C   1 
ATOM 2368 O O   . GLY A 1 441 ? 144.276 132.669 142.906 1.00 53.44  ? 362 GLY A O   1 
ATOM 2369 N N   . ILE A 1 442 ? 143.070 133.788 141.369 1.00 49.45  ? 363 ILE A N   1 
ATOM 2370 C CA  . ILE A 1 442 ? 144.104 133.663 140.344 1.00 52.02  ? 363 ILE A CA  1 
ATOM 2371 C C   . ILE A 1 442 ? 145.335 134.484 140.719 1.00 59.34  ? 363 ILE A C   1 
ATOM 2372 O O   . ILE A 1 442 ? 146.473 134.063 140.479 1.00 65.38  ? 363 ILE A O   1 
ATOM 2373 C CB  . ILE A 1 442 ? 143.535 134.056 138.965 1.00 46.06  ? 363 ILE A CB  1 
ATOM 2374 C CG1 . ILE A 1 442 ? 144.650 134.229 137.933 1.00 50.39  ? 363 ILE A CG1 1 
ATOM 2375 C CG2 . ILE A 1 442 ? 142.737 135.340 139.062 1.00 39.17  ? 363 ILE A CG2 1 
ATOM 2376 C CD1 . ILE A 1 442 ? 144.155 134.485 136.541 1.00 48.79  ? 363 ILE A CD1 1 
ATOM 2377 N N   . GLU A 1 443 ? 145.127 135.649 141.344 1.00 57.24  ? 364 GLU A N   1 
ATOM 2378 C CA  . GLU A 1 443 ? 146.241 136.513 141.727 1.00 58.60  ? 364 GLU A CA  1 
ATOM 2379 C C   . GLU A 1 443 ? 147.155 135.830 142.741 1.00 64.04  ? 364 GLU A C   1 
ATOM 2380 O O   . GLU A 1 443 ? 148.382 135.977 142.678 1.00 65.94  ? 364 GLU A O   1 
ATOM 2381 C CB  . GLU A 1 443 ? 145.700 137.835 142.278 1.00 54.25  ? 364 GLU A CB  1 
ATOM 2382 C CG  . GLU A 1 443 ? 146.474 138.390 143.458 1.00 59.59  ? 364 GLU A CG  1 
ATOM 2383 C CD  . GLU A 1 443 ? 145.995 139.743 143.905 1.00 64.12  ? 364 GLU A CD  1 
ATOM 2384 O OE1 . GLU A 1 443 ? 144.974 140.198 143.372 1.00 61.24  ? 364 GLU A OE1 1 
ATOM 2385 O OE2 . GLU A 1 443 ? 146.636 140.355 144.783 1.00 63.69  ? 364 GLU A OE2 1 
ATOM 2386 N N   . THR A 1 444 ? 146.572 135.062 143.668 1.00 62.67  ? 365 THR A N   1 
ATOM 2387 C CA  . THR A 1 444 ? 147.368 134.335 144.652 1.00 62.51  ? 365 THR A CA  1 
ATOM 2388 C C   . THR A 1 444 ? 148.263 133.293 143.990 1.00 70.24  ? 365 THR A C   1 
ATOM 2389 O O   . THR A 1 444 ? 149.435 133.149 144.357 1.00 75.05  ? 365 THR A O   1 
ATOM 2390 C CB  . THR A 1 444 ? 146.451 133.673 145.680 1.00 58.32  ? 365 THR A CB  1 
ATOM 2391 O OG1 . THR A 1 444 ? 145.548 132.784 145.012 1.00 56.98  ? 365 THR A OG1 1 
ATOM 2392 C CG2 . THR A 1 444 ? 145.654 134.722 146.431 1.00 54.25  ? 365 THR A CG2 1 
ATOM 2393 N N   . LEU A 1 445 ? 147.733 132.559 143.009 1.00 68.48  ? 366 LEU A N   1 
ATOM 2394 C CA  . LEU A 1 445 ? 148.558 131.591 142.295 1.00 70.27  ? 366 LEU A CA  1 
ATOM 2395 C C   . LEU A 1 445 ? 149.492 132.266 141.298 1.00 73.93  ? 366 LEU A C   1 
ATOM 2396 O O   . LEU A 1 445 ? 150.587 131.754 141.041 1.00 78.23  ? 366 LEU A O   1 
ATOM 2397 C CB  . LEU A 1 445 ? 147.670 130.541 141.610 1.00 66.92  ? 366 LEU A CB  1 
ATOM 2398 C CG  . LEU A 1 445 ? 146.773 130.815 140.392 1.00 62.80  ? 366 LEU A CG  1 
ATOM 2399 C CD1 . LEU A 1 445 ? 147.493 130.652 139.050 1.00 64.72  ? 366 LEU A CD1 1 
ATOM 2400 C CD2 . LEU A 1 445 ? 145.534 129.935 140.440 1.00 61.72  ? 366 LEU A CD2 1 
ATOM 2401 N N   . ALA A 1 446 ? 149.088 133.405 140.727 1.00 70.13  ? 367 ALA A N   1 
ATOM 2402 C CA  . ALA A 1 446 ? 149.959 134.113 139.796 1.00 73.84  ? 367 ALA A CA  1 
ATOM 2403 C C   . ALA A 1 446 ? 151.077 134.865 140.505 1.00 80.07  ? 367 ALA A C   1 
ATOM 2404 O O   . ALA A 1 446 ? 152.058 135.244 139.857 1.00 83.66  ? 367 ALA A O   1 
ATOM 2405 C CB  . ALA A 1 446 ? 149.149 135.083 138.934 1.00 64.22  ? 367 ALA A CB  1 
ATOM 2406 N N   . ALA A 1 447 ? 150.952 135.093 141.814 1.00 75.82  ? 368 ALA A N   1 
ATOM 2407 C CA  . ALA A 1 447 ? 152.004 135.798 142.536 1.00 77.03  ? 368 ALA A CA  1 
ATOM 2408 C C   . ALA A 1 447 ? 153.221 134.907 142.759 1.00 80.77  ? 368 ALA A C   1 
ATOM 2409 O O   . ALA A 1 447 ? 154.357 135.393 142.759 1.00 82.04  ? 368 ALA A O   1 
ATOM 2410 C CB  . ALA A 1 447 ? 151.467 136.329 143.863 1.00 72.00  ? 368 ALA A CB  1 
ATOM 2411 N N   . VAL A 1 448 ? 153.011 133.602 142.959 1.00 80.70  ? 369 VAL A N   1 
ATOM 2412 C CA  . VAL A 1 448 ? 154.155 132.705 143.076 1.00 83.12  ? 369 VAL A CA  1 
ATOM 2413 C C   . VAL A 1 448 ? 154.789 132.440 141.712 1.00 84.93  ? 369 VAL A C   1 
ATOM 2414 O O   . VAL A 1 448 ? 155.954 132.031 141.646 1.00 90.38  ? 369 VAL A O   1 
ATOM 2415 C CB  . VAL A 1 448 ? 153.767 131.391 143.792 1.00 84.69  ? 369 VAL A CB  1 
ATOM 2416 C CG1 . VAL A 1 448 ? 152.894 131.671 144.992 1.00 83.37  ? 369 VAL A CG1 1 
ATOM 2417 C CG2 . VAL A 1 448 ? 153.036 130.448 142.873 1.00 86.07  ? 369 VAL A CG2 1 
ATOM 2418 N N   . PHE A 1 449 ? 154.059 132.676 140.617 1.00 83.21  ? 370 PHE A N   1 
ATOM 2419 C CA  . PHE A 1 449 ? 154.639 132.647 139.275 1.00 83.54  ? 370 PHE A CA  1 
ATOM 2420 C C   . PHE A 1 449 ? 155.272 133.975 138.884 1.00 82.62  ? 370 PHE A C   1 
ATOM 2421 O O   . PHE A 1 449 ? 155.972 134.028 137.866 1.00 85.86  ? 370 PHE A O   1 
ATOM 2422 C CB  . PHE A 1 449 ? 153.606 132.279 138.180 1.00 84.06  ? 370 PHE A CB  1 
ATOM 2423 C CG  . PHE A 1 449 ? 152.782 131.006 138.420 1.00 87.83  ? 370 PHE A CG  1 
ATOM 2424 C CD1 . PHE A 1 449 ? 151.775 130.675 137.524 1.00 90.32  ? 370 PHE A CD1 1 
ATOM 2425 C CD2 . PHE A 1 449 ? 153.097 130.078 139.402 1.00 89.39  ? 370 PHE A CD2 1 
ATOM 2426 C CE1 . PHE A 1 449 ? 151.021 129.520 137.683 1.00 93.48  ? 370 PHE A CE1 1 
ATOM 2427 C CE2 . PHE A 1 449 ? 152.352 128.926 139.567 1.00 91.34  ? 370 PHE A CE2 1 
ATOM 2428 C CZ  . PHE A 1 449 ? 151.319 128.641 138.701 1.00 92.27  ? 370 PHE A CZ  1 
ATOM 2429 N N   . SER A 1 450 ? 155.030 135.039 139.657 1.00 76.53  ? 371 SER A N   1 
ATOM 2430 C CA  . SER A 1 450 ? 155.516 136.365 139.286 1.00 79.32  ? 371 SER A CA  1 
ATOM 2431 C C   . SER A 1 450 ? 157.037 136.445 139.341 1.00 86.57  ? 371 SER A C   1 
ATOM 2432 O O   . SER A 1 450 ? 157.665 136.988 138.426 1.00 89.07  ? 371 SER A O   1 
ATOM 2433 C CB  . SER A 1 450 ? 154.895 137.424 140.198 1.00 82.78  ? 371 SER A CB  1 
ATOM 2434 O OG  . SER A 1 450 ? 155.387 138.717 139.884 1.00 90.48  ? 371 SER A OG  1 
ATOM 2435 N N   . GLY A 1 451 ? 157.644 135.907 140.402 1.00 84.99  ? 372 GLY A N   1 
ATOM 2436 C CA  . GLY A 1 451 ? 159.093 135.948 140.526 1.00 83.55  ? 372 GLY A CA  1 
ATOM 2437 C C   . GLY A 1 451 ? 159.813 135.160 139.451 1.00 84.61  ? 372 GLY A C   1 
ATOM 2438 O O   . GLY A 1 451 ? 160.923 135.521 139.050 1.00 89.92  ? 372 GLY A O   1 
ATOM 2439 N N   . LEU A 1 452 ? 159.202 134.070 138.983 1.00 82.86  ? 373 LEU A N   1 
ATOM 2440 C CA  . LEU A 1 452 ? 159.733 133.349 137.832 1.00 86.47  ? 373 LEU A CA  1 
ATOM 2441 C C   . LEU A 1 452 ? 159.680 134.215 136.579 1.00 88.74  ? 373 LEU A C   1 
ATOM 2442 O O   . LEU A 1 452 ? 160.602 134.183 135.756 1.00 92.28  ? 373 LEU A O   1 
ATOM 2443 C CB  . LEU A 1 452 ? 158.950 132.046 137.641 1.00 84.11  ? 373 LEU A CB  1 
ATOM 2444 C CG  . LEU A 1 452 ? 159.557 130.834 136.924 1.00 86.17  ? 373 LEU A CG  1 
ATOM 2445 C CD1 . LEU A 1 452 ? 158.776 129.585 137.299 1.00 80.69  ? 373 LEU A CD1 1 
ATOM 2446 C CD2 . LEU A 1 452 ? 159.583 130.988 135.409 1.00 89.33  ? 373 LEU A CD2 1 
ATOM 2447 N N   . VAL A 1 453 ? 158.605 134.990 136.417 1.00 86.25  ? 374 VAL A N   1 
ATOM 2448 C CA  . VAL A 1 453 ? 158.470 135.860 135.253 1.00 83.16  ? 374 VAL A CA  1 
ATOM 2449 C C   . VAL A 1 453 ? 159.469 137.014 135.326 1.00 84.83  ? 374 VAL A C   1 
ATOM 2450 O O   . VAL A 1 453 ? 160.083 137.384 134.317 1.00 88.80  ? 374 VAL A O   1 
ATOM 2451 C CB  . VAL A 1 453 ? 157.011 136.346 135.136 1.00 77.82  ? 374 VAL A CB  1 
ATOM 2452 C CG1 . VAL A 1 453 ? 156.917 137.692 134.443 1.00 72.69  ? 374 VAL A CG1 1 
ATOM 2453 C CG2 . VAL A 1 453 ? 156.163 135.313 134.406 1.00 74.30  ? 374 VAL A CG2 1 
ATOM 2454 N N   . ILE A 1 454 ? 159.663 137.580 136.524 1.00 85.21  ? 375 ILE A N   1 
ATOM 2455 C CA  . ILE A 1 454 ? 160.614 138.677 136.711 1.00 88.42  ? 375 ILE A CA  1 
ATOM 2456 C C   . ILE A 1 454 ? 162.036 138.219 136.409 1.00 91.51  ? 375 ILE A C   1 
ATOM 2457 O O   . ILE A 1 454 ? 162.810 138.929 135.753 1.00 89.31  ? 375 ILE A O   1 
ATOM 2458 C CB  . ILE A 1 454 ? 160.502 139.241 138.143 1.00 88.08  ? 375 ILE A CB  1 
ATOM 2459 C CG1 . ILE A 1 454 ? 159.116 139.840 138.395 1.00 85.40  ? 375 ILE A CG1 1 
ATOM 2460 C CG2 . ILE A 1 454 ? 161.592 140.272 138.419 1.00 89.15  ? 375 ILE A CG2 1 
ATOM 2461 C CD1 . ILE A 1 454 ? 158.897 141.182 137.763 1.00 79.27  ? 375 ILE A CD1 1 
ATOM 2462 N N   . GLU A 1 455 ? 162.394 137.017 136.864 1.00 92.60  ? 376 GLU A N   1 
ATOM 2463 C CA  . GLU A 1 455 ? 163.774 136.552 136.762 1.00 94.96  ? 376 GLU A CA  1 
ATOM 2464 C C   . GLU A 1 455 ? 164.169 136.237 135.323 1.00 97.60  ? 376 GLU A C   1 
ATOM 2465 O O   . GLU A 1 455 ? 165.266 136.602 134.884 1.00 97.70  ? 376 GLU A O   1 
ATOM 2466 C CB  . GLU A 1 455 ? 163.967 135.319 137.644 1.00 97.96  ? 376 GLU A CB  1 
ATOM 2467 C CG  . GLU A 1 455 ? 165.360 135.168 138.228 1.00 102.78 ? 376 GLU A CG  1 
ATOM 2468 C CD  . GLU A 1 455 ? 165.406 134.145 139.347 1.00 107.88 ? 376 GLU A CD  1 
ATOM 2469 O OE1 . GLU A 1 455 ? 165.074 132.969 139.090 1.00 111.13 ? 376 GLU A OE1 1 
ATOM 2470 O OE2 . GLU A 1 455 ? 165.770 134.516 140.482 1.00 105.18 ? 376 GLU A OE2 1 
ATOM 2471 N N   . HIS A 1 456 ? 163.296 135.569 134.572 1.00 95.53  ? 377 HIS A N   1 
ATOM 2472 C CA  . HIS A 1 456 ? 163.703 134.895 133.346 1.00 97.80  ? 377 HIS A CA  1 
ATOM 2473 C C   . HIS A 1 456 ? 163.328 135.624 132.060 1.00 93.84  ? 377 HIS A C   1 
ATOM 2474 O O   . HIS A 1 456 ? 163.578 135.082 130.979 1.00 97.56  ? 377 HIS A O   1 
ATOM 2475 C CB  . HIS A 1 456 ? 163.117 133.479 133.312 1.00 101.76 ? 377 HIS A CB  1 
ATOM 2476 C CG  . HIS A 1 456 ? 164.078 132.417 133.750 1.00 112.03 ? 377 HIS A CG  1 
ATOM 2477 N ND1 . HIS A 1 456 ? 165.008 131.860 132.898 1.00 116.67 ? 377 HIS A ND1 1 
ATOM 2478 C CD2 . HIS A 1 456 ? 164.255 131.812 134.948 1.00 113.52 ? 377 HIS A CD2 1 
ATOM 2479 C CE1 . HIS A 1 456 ? 165.715 130.956 133.553 1.00 120.15 ? 377 HIS A CE1 1 
ATOM 2480 N NE2 . HIS A 1 456 ? 165.278 130.907 134.798 1.00 122.40 ? 377 HIS A NE2 1 
ATOM 2481 N N   . LEU A 1 457 ? 162.739 136.818 132.122 1.00 88.85  ? 378 LEU A N   1 
ATOM 2482 C CA  . LEU A 1 457 ? 162.410 137.500 130.874 1.00 87.63  ? 378 LEU A CA  1 
ATOM 2483 C C   . LEU A 1 457 ? 163.070 138.866 130.759 1.00 84.35  ? 378 LEU A C   1 
ATOM 2484 O O   . LEU A 1 457 ? 163.689 139.162 129.729 1.00 81.90  ? 378 LEU A O   1 
ATOM 2485 C CB  . LEU A 1 457 ? 160.874 137.603 130.717 1.00 89.37  ? 378 LEU A CB  1 
ATOM 2486 C CG  . LEU A 1 457 ? 160.114 138.498 129.716 1.00 90.22  ? 378 LEU A CG  1 
ATOM 2487 C CD1 . LEU A 1 457 ? 158.716 137.924 129.536 1.00 92.44  ? 378 LEU A CD1 1 
ATOM 2488 C CD2 . LEU A 1 457 ? 159.991 139.970 130.077 1.00 78.70  ? 378 LEU A CD2 1 
ATOM 2489 N N   . GLY A 1 458 ? 162.955 139.707 131.774 1.00 81.22  ? 379 GLY A N   1 
ATOM 2490 C CA  . GLY A 1 458 ? 163.475 141.057 131.709 1.00 77.88  ? 379 GLY A CA  1 
ATOM 2491 C C   . GLY A 1 458 ? 162.661 141.982 132.591 1.00 76.79  ? 379 GLY A C   1 
ATOM 2492 O O   . GLY A 1 458 ? 161.815 141.545 133.366 1.00 82.42  ? 379 GLY A O   1 
ATOM 2493 N N   . ARG A 1 459 ? 162.940 143.277 132.457 1.00 71.67  ? 380 ARG A N   1 
ATOM 2494 C CA  . ARG A 1 459 ? 162.253 144.315 133.220 1.00 69.41  ? 380 ARG A CA  1 
ATOM 2495 C C   . ARG A 1 459 ? 161.481 145.296 132.356 1.00 64.16  ? 380 ARG A C   1 
ATOM 2496 O O   . ARG A 1 459 ? 160.348 145.646 132.696 1.00 65.24  ? 380 ARG A O   1 
ATOM 2497 C CB  . ARG A 1 459 ? 163.252 145.098 134.085 1.00 72.35  ? 380 ARG A CB  1 
ATOM 2498 C CG  . ARG A 1 459 ? 162.670 145.614 135.393 1.00 69.48  ? 380 ARG A CG  1 
ATOM 2499 C CD  . ARG A 1 459 ? 163.732 145.731 136.475 1.00 68.66  ? 380 ARG A CD  1 
ATOM 2500 N NE  . ARG A 1 459 ? 164.523 144.514 136.612 1.00 75.94  ? 380 ARG A NE  1 
ATOM 2501 C CZ  . ARG A 1 459 ? 164.131 143.434 137.273 1.00 81.39  ? 380 ARG A CZ  1 
ATOM 2502 N NH1 . ARG A 1 459 ? 162.961 143.384 137.888 1.00 84.63  ? 380 ARG A NH1 1 
ATOM 2503 N NH2 . ARG A 1 459 ? 164.938 142.378 137.326 1.00 81.66  ? 380 ARG A NH2 1 
ATOM 2504 N N   . ARG A 1 460 ? 162.059 145.759 131.256 1.00 63.08  ? 381 ARG A N   1 
ATOM 2505 C CA  . ARG A 1 460 ? 161.367 146.722 130.405 1.00 62.13  ? 381 ARG A CA  1 
ATOM 2506 C C   . ARG A 1 460 ? 160.293 146.067 129.526 1.00 63.51  ? 381 ARG A C   1 
ATOM 2507 O O   . ARG A 1 460 ? 159.208 146.650 129.408 1.00 60.13  ? 381 ARG A O   1 
ATOM 2508 C CB  . ARG A 1 460 ? 162.373 147.525 129.564 1.00 63.35  ? 381 ARG A CB  1 
ATOM 2509 C CG  . ARG A 1 460 ? 161.771 148.232 128.355 1.00 59.31  ? 381 ARG A CG  1 
ATOM 2510 C CD  . ARG A 1 460 ? 162.828 148.600 127.333 1.00 59.78  ? 381 ARG A CD  1 
ATOM 2511 N NE  . ARG A 1 460 ? 162.261 148.799 126.004 1.00 61.24  ? 381 ARG A NE  1 
ATOM 2512 C CZ  . ARG A 1 460 ? 161.759 149.944 125.565 1.00 62.43  ? 381 ARG A CZ  1 
ATOM 2513 N NH1 . ARG A 1 460 ? 161.718 151.021 126.331 1.00 60.70  ? 381 ARG A NH1 1 
ATOM 2514 N NH2 . ARG A 1 460 ? 161.289 150.012 124.323 1.00 61.90  ? 381 ARG A NH2 1 
ATOM 2515 N N   . PRO A 1 461 ? 160.508 144.887 128.903 1.00 63.96  ? 382 PRO A N   1 
ATOM 2516 C CA  . PRO A 1 461 ? 159.390 144.258 128.168 1.00 57.98  ? 382 PRO A CA  1 
ATOM 2517 C C   . PRO A 1 461 ? 158.168 143.941 129.018 1.00 53.85  ? 382 PRO A C   1 
ATOM 2518 O O   . PRO A 1 461 ? 157.059 143.876 128.475 1.00 51.91  ? 382 PRO A O   1 
ATOM 2519 C CB  . PRO A 1 461 ? 160.010 142.968 127.605 1.00 61.83  ? 382 PRO A CB  1 
ATOM 2520 C CG  . PRO A 1 461 ? 161.366 142.866 128.191 1.00 64.58  ? 382 PRO A CG  1 
ATOM 2521 C CD  . PRO A 1 461 ? 161.777 144.246 128.503 1.00 63.13  ? 382 PRO A CD  1 
ATOM 2522 N N   . LEU A 1 462 ? 158.334 143.729 130.325 1.00 56.08  ? 383 LEU A N   1 
ATOM 2523 C CA  . LEU A 1 462 ? 157.178 143.471 131.178 1.00 53.12  ? 383 LEU A CA  1 
ATOM 2524 C C   . LEU A 1 462 ? 156.297 144.704 131.332 1.00 48.96  ? 383 LEU A C   1 
ATOM 2525 O O   . LEU A 1 462 ? 155.071 144.583 131.393 1.00 52.23  ? 383 LEU A O   1 
ATOM 2526 C CB  . LEU A 1 462 ? 157.621 142.973 132.549 1.00 52.92  ? 383 LEU A CB  1 
ATOM 2527 C CG  . LEU A 1 462 ? 157.984 141.497 132.662 1.00 58.76  ? 383 LEU A CG  1 
ATOM 2528 C CD1 . LEU A 1 462 ? 158.359 141.137 134.084 1.00 64.35  ? 383 LEU A CD1 1 
ATOM 2529 C CD2 . LEU A 1 462 ? 156.839 140.631 132.166 1.00 59.35  ? 383 LEU A CD2 1 
ATOM 2530 N N   . LEU A 1 463 ? 156.896 145.893 131.424 1.00 47.55  ? 384 LEU A N   1 
ATOM 2531 C CA  . LEU A 1 463 ? 156.101 147.081 131.725 1.00 48.19  ? 384 LEU A CA  1 
ATOM 2532 C C   . LEU A 1 463 ? 155.239 147.500 130.538 1.00 50.38  ? 384 LEU A C   1 
ATOM 2533 O O   . LEU A 1 463 ? 154.050 147.791 130.703 1.00 52.25  ? 384 LEU A O   1 
ATOM 2534 C CB  . LEU A 1 463 ? 157.005 148.224 132.183 1.00 53.67  ? 384 LEU A CB  1 
ATOM 2535 C CG  . LEU A 1 463 ? 156.445 148.941 133.415 1.00 50.19  ? 384 LEU A CG  1 
ATOM 2536 C CD1 . LEU A 1 463 ? 156.207 147.961 134.550 1.00 52.70  ? 384 LEU A CD1 1 
ATOM 2537 C CD2 . LEU A 1 463 ? 157.375 150.038 133.868 1.00 49.92  ? 384 LEU A CD2 1 
ATOM 2538 N N   . ILE A 1 464 ? 155.809 147.539 129.333 1.00 50.86  ? 385 ILE A N   1 
ATOM 2539 C CA  . ILE A 1 464 ? 154.975 147.760 128.154 1.00 49.30  ? 385 ILE A CA  1 
ATOM 2540 C C   . ILE A 1 464 ? 154.084 146.548 127.903 1.00 48.27  ? 385 ILE A C   1 
ATOM 2541 O O   . ILE A 1 464 ? 152.917 146.687 127.513 1.00 47.54  ? 385 ILE A O   1 
ATOM 2542 C CB  . ILE A 1 464 ? 155.827 148.121 126.917 1.00 53.50  ? 385 ILE A CB  1 
ATOM 2543 C CG1 . ILE A 1 464 ? 156.720 149.342 127.175 1.00 55.20  ? 385 ILE A CG1 1 
ATOM 2544 C CG2 . ILE A 1 464 ? 154.949 148.398 125.706 1.00 55.28  ? 385 ILE A CG2 1 
ATOM 2545 C CD1 . ILE A 1 464 ? 158.145 149.041 127.559 1.00 54.18  ? 385 ILE A CD1 1 
ATOM 2546 N N   . GLY A 1 465 ? 154.607 145.344 128.147 1.00 48.00  ? 386 GLY A N   1 
ATOM 2547 C CA  . GLY A 1 465 ? 153.799 144.144 128.003 1.00 41.81  ? 386 GLY A CA  1 
ATOM 2548 C C   . GLY A 1 465 ? 152.666 144.043 129.006 1.00 43.29  ? 386 GLY A C   1 
ATOM 2549 O O   . GLY A 1 465 ? 151.589 143.543 128.675 1.00 41.99  ? 386 GLY A O   1 
ATOM 2550 N N   . GLY A 1 466 ? 152.888 144.507 130.234 1.00 46.97  ? 387 GLY A N   1 
ATOM 2551 C CA  . GLY A 1 466 ? 151.876 144.441 131.272 1.00 42.28  ? 387 GLY A CA  1 
ATOM 2552 C C   . GLY A 1 466 ? 150.664 145.305 131.005 1.00 40.01  ? 387 GLY A C   1 
ATOM 2553 O O   . GLY A 1 466 ? 149.539 144.800 130.957 1.00 44.34  ? 387 GLY A O   1 
ATOM 2554 N N   . PHE A 1 467 ? 150.873 146.611 130.833 1.00 36.97  ? 388 PHE A N   1 
ATOM 2555 C CA  . PHE A 1 467 ? 149.764 147.488 130.478 1.00 38.83  ? 388 PHE A CA  1 
ATOM 2556 C C   . PHE A 1 467 ? 149.295 147.278 129.044 1.00 41.82  ? 388 PHE A C   1 
ATOM 2557 O O   . PHE A 1 467 ? 148.162 147.647 128.718 1.00 42.53  ? 388 PHE A O   1 
ATOM 2558 C CB  . PHE A 1 467 ? 150.124 148.966 130.685 1.00 38.01  ? 388 PHE A CB  1 
ATOM 2559 C CG  . PHE A 1 467 ? 150.587 149.313 132.080 1.00 42.70  ? 388 PHE A CG  1 
ATOM 2560 C CD1 . PHE A 1 467 ? 151.896 149.102 132.481 1.00 45.87  ? 388 PHE A CD1 1 
ATOM 2561 C CD2 . PHE A 1 467 ? 149.701 149.862 132.991 1.00 44.89  ? 388 PHE A CD2 1 
ATOM 2562 C CE1 . PHE A 1 467 ? 152.311 149.429 133.755 1.00 42.87  ? 388 PHE A CE1 1 
ATOM 2563 C CE2 . PHE A 1 467 ? 150.110 150.187 134.268 1.00 43.21  ? 388 PHE A CE2 1 
ATOM 2564 C CZ  . PHE A 1 467 ? 151.416 149.970 134.650 1.00 41.25  ? 388 PHE A CZ  1 
ATOM 2565 N N   . GLY A 1 468 ? 150.138 146.707 128.181 1.00 40.96  ? 389 GLY A N   1 
ATOM 2566 C CA  . GLY A 1 468 ? 149.692 146.381 126.837 1.00 38.19  ? 389 GLY A CA  1 
ATOM 2567 C C   . GLY A 1 468 ? 148.640 145.289 126.822 1.00 38.59  ? 389 GLY A C   1 
ATOM 2568 O O   . GLY A 1 468 ? 147.650 145.378 126.091 1.00 37.86  ? 389 GLY A O   1 
ATOM 2569 N N   . LEU A 1 469 ? 148.840 144.243 127.627 1.00 39.96  ? 390 LEU A N   1 
ATOM 2570 C CA  . LEU A 1 469 ? 147.820 143.209 127.761 1.00 38.99  ? 390 LEU A CA  1 
ATOM 2571 C C   . LEU A 1 469 ? 146.598 143.722 128.509 1.00 36.90  ? 390 LEU A C   1 
ATOM 2572 O O   . LEU A 1 469 ? 145.484 143.248 128.264 1.00 36.57  ? 390 LEU A O   1 
ATOM 2573 C CB  . LEU A 1 469 ? 148.393 141.980 128.466 1.00 33.86  ? 390 LEU A CB  1 
ATOM 2574 C CG  . LEU A 1 469 ? 149.481 141.195 127.734 1.00 30.65  ? 390 LEU A CG  1 
ATOM 2575 C CD1 . LEU A 1 469 ? 149.749 139.880 128.442 1.00 32.25  ? 390 LEU A CD1 1 
ATOM 2576 C CD2 . LEU A 1 469 ? 149.097 140.954 126.285 1.00 32.93  ? 390 LEU A CD2 1 
ATOM 2577 N N   . MET A 1 470 ? 146.786 144.672 129.429 1.00 34.84  ? 391 MET A N   1 
ATOM 2578 C CA  . MET A 1 470 ? 145.651 145.273 130.123 1.00 35.02  ? 391 MET A CA  1 
ATOM 2579 C C   . MET A 1 470 ? 144.738 146.005 129.151 1.00 37.33  ? 391 MET A C   1 
ATOM 2580 O O   . MET A 1 470 ? 143.526 145.768 129.127 1.00 40.60  ? 391 MET A O   1 
ATOM 2581 C CB  . MET A 1 470 ? 146.141 146.230 131.206 1.00 35.74  ? 391 MET A CB  1 
ATOM 2582 C CG  . MET A 1 470 ? 146.620 145.558 132.467 1.00 37.56  ? 391 MET A CG  1 
ATOM 2583 S SD  . MET A 1 470 ? 146.228 146.568 133.901 1.00 46.99  ? 391 MET A SD  1 
ATOM 2584 C CE  . MET A 1 470 ? 147.213 145.758 135.147 1.00 42.78  ? 391 MET A CE  1 
ATOM 2585 N N   . GLY A 1 471 ? 145.312 146.885 128.326 1.00 36.15  ? 392 GLY A N   1 
ATOM 2586 C CA  . GLY A 1 471 ? 144.508 147.649 127.384 1.00 36.31  ? 392 GLY A CA  1 
ATOM 2587 C C   . GLY A 1 471 ? 143.831 146.780 126.342 1.00 35.69  ? 392 GLY A C   1 
ATOM 2588 O O   . GLY A 1 471 ? 142.717 147.076 125.904 1.00 35.52  ? 392 GLY A O   1 
ATOM 2589 N N   . LEU A 1 472 ? 144.500 145.704 125.922 1.00 36.20  ? 393 LEU A N   1 
ATOM 2590 C CA  . LEU A 1 472 ? 143.871 144.755 125.010 1.00 33.48  ? 393 LEU A CA  1 
ATOM 2591 C C   . LEU A 1 472 ? 142.714 144.034 125.690 1.00 37.86  ? 393 LEU A C   1 
ATOM 2592 O O   . LEU A 1 472 ? 141.591 144.018 125.175 1.00 40.97  ? 393 LEU A O   1 
ATOM 2593 C CB  . LEU A 1 472 ? 144.906 143.752 124.497 1.00 33.44  ? 393 LEU A CB  1 
ATOM 2594 C CG  . LEU A 1 472 ? 144.376 142.440 123.912 1.00 36.85  ? 393 LEU A CG  1 
ATOM 2595 C CD1 . LEU A 1 472 ? 143.623 142.682 122.609 1.00 43.67  ? 393 LEU A CD1 1 
ATOM 2596 C CD2 . LEU A 1 472 ? 145.504 141.446 123.701 1.00 39.18  ? 393 LEU A CD2 1 
ATOM 2597 N N   . PHE A 1 473 ? 142.960 143.459 126.871 1.00 38.54  ? 394 PHE A N   1 
ATOM 2598 C CA  . PHE A 1 473 ? 141.918 142.713 127.566 1.00 35.55  ? 394 PHE A CA  1 
ATOM 2599 C C   . PHE A 1 473 ? 140.873 143.611 128.214 1.00 35.73  ? 394 PHE A C   1 
ATOM 2600 O O   . PHE A 1 473 ? 139.811 143.110 128.596 1.00 36.13  ? 394 PHE A O   1 
ATOM 2601 C CB  . PHE A 1 473 ? 142.533 141.781 128.610 1.00 30.76  ? 394 PHE A CB  1 
ATOM 2602 C CG  . PHE A 1 473 ? 143.130 140.533 128.025 1.00 31.44  ? 394 PHE A CG  1 
ATOM 2603 C CD1 . PHE A 1 473 ? 142.320 139.582 127.429 1.00 35.59  ? 394 PHE A CD1 1 
ATOM 2604 C CD2 . PHE A 1 473 ? 144.494 140.304 128.075 1.00 32.59  ? 394 PHE A CD2 1 
ATOM 2605 C CE1 . PHE A 1 473 ? 142.859 138.431 126.889 1.00 37.78  ? 394 PHE A CE1 1 
ATOM 2606 C CE2 . PHE A 1 473 ? 145.040 139.156 127.536 1.00 34.96  ? 394 PHE A CE2 1 
ATOM 2607 C CZ  . PHE A 1 473 ? 144.221 138.218 126.943 1.00 38.03  ? 394 PHE A CZ  1 
ATOM 2608 N N   . PHE A 1 474 ? 141.141 144.911 128.354 1.00 35.53  ? 395 PHE A N   1 
ATOM 2609 C CA  . PHE A 1 474 ? 140.061 145.837 128.677 1.00 35.08  ? 395 PHE A CA  1 
ATOM 2610 C C   . PHE A 1 474 ? 139.149 146.036 127.474 1.00 37.29  ? 395 PHE A C   1 
ATOM 2611 O O   . PHE A 1 474 ? 137.939 146.230 127.637 1.00 38.27  ? 395 PHE A O   1 
ATOM 2612 C CB  . PHE A 1 474 ? 140.626 147.179 129.145 1.00 36.39  ? 395 PHE A CB  1 
ATOM 2613 C CG  . PHE A 1 474 ? 140.864 147.257 130.630 1.00 36.96  ? 395 PHE A CG  1 
ATOM 2614 C CD1 . PHE A 1 474 ? 139.872 146.910 131.528 1.00 32.92  ? 395 PHE A CD1 1 
ATOM 2615 C CD2 . PHE A 1 474 ? 142.084 147.687 131.125 1.00 38.92  ? 395 PHE A CD2 1 
ATOM 2616 C CE1 . PHE A 1 474 ? 140.102 146.978 132.892 1.00 31.79  ? 395 PHE A CE1 1 
ATOM 2617 C CE2 . PHE A 1 474 ? 142.314 147.757 132.484 1.00 36.45  ? 395 PHE A CE2 1 
ATOM 2618 C CZ  . PHE A 1 474 ? 141.320 147.404 133.367 1.00 31.37  ? 395 PHE A CZ  1 
ATOM 2619 N N   . GLY A 1 475 ? 139.716 146.008 126.266 1.00 37.29  ? 396 GLY A N   1 
ATOM 2620 C CA  . GLY A 1 475 ? 138.895 146.037 125.067 1.00 36.77  ? 396 GLY A CA  1 
ATOM 2621 C C   . GLY A 1 475 ? 138.073 144.775 124.885 1.00 37.89  ? 396 GLY A C   1 
ATOM 2622 O O   . GLY A 1 475 ? 136.899 144.840 124.514 1.00 41.07  ? 396 GLY A O   1 
ATOM 2623 N N   . THR A 1 476 ? 138.680 143.608 125.133 1.00 36.90  ? 397 THR A N   1 
ATOM 2624 C CA  . THR A 1 476 ? 137.916 142.363 125.105 1.00 38.67  ? 397 THR A CA  1 
ATOM 2625 C C   . THR A 1 476 ? 136.923 142.291 126.255 1.00 39.68  ? 397 THR A C   1 
ATOM 2626 O O   . THR A 1 476 ? 135.912 141.588 126.153 1.00 41.94  ? 397 THR A O   1 
ATOM 2627 C CB  . THR A 1 476 ? 138.843 141.147 125.141 1.00 39.42  ? 397 THR A CB  1 
ATOM 2628 O OG1 . THR A 1 476 ? 139.273 140.905 126.486 1.00 37.88  ? 397 THR A OG1 1 
ATOM 2629 C CG2 . THR A 1 476 ? 140.044 141.347 124.235 1.00 39.08  ? 397 THR A CG2 1 
ATOM 2630 N N   . LEU A 1 477 ? 137.203 142.982 127.362 1.00 38.71  ? 398 LEU A N   1 
ATOM 2631 C CA  . LEU A 1 477 ? 136.174 143.187 128.374 1.00 37.80  ? 398 LEU A CA  1 
ATOM 2632 C C   . LEU A 1 477 ? 135.026 144.010 127.811 1.00 40.00  ? 398 LEU A C   1 
ATOM 2633 O O   . LEU A 1 477 ? 133.859 143.633 127.944 1.00 42.61  ? 398 LEU A O   1 
ATOM 2634 C CB  . LEU A 1 477 ? 136.764 143.873 129.606 1.00 37.11  ? 398 LEU A CB  1 
ATOM 2635 C CG  . LEU A 1 477 ? 135.937 143.874 130.896 1.00 34.58  ? 398 LEU A CG  1 
ATOM 2636 C CD1 . LEU A 1 477 ? 135.092 142.616 131.046 1.00 37.23  ? 398 LEU A CD1 1 
ATOM 2637 C CD2 . LEU A 1 477 ? 136.839 144.069 132.101 1.00 36.56  ? 398 LEU A CD2 1 
ATOM 2638 N N   . THR A 1 478 ? 135.351 145.123 127.144 1.00 40.10  ? 399 THR A N   1 
ATOM 2639 C CA  . THR A 1 478 ? 134.330 146.063 126.688 1.00 39.74  ? 399 THR A CA  1 
ATOM 2640 C C   . THR A 1 478 ? 133.414 145.441 125.642 1.00 41.32  ? 399 THR A C   1 
ATOM 2641 O O   . THR A 1 478 ? 132.209 145.707 125.632 1.00 43.76  ? 399 THR A O   1 
ATOM 2642 C CB  . THR A 1 478 ? 134.986 147.323 126.130 1.00 42.15  ? 399 THR A CB  1 
ATOM 2643 O OG1 . THR A 1 478 ? 136.137 147.651 126.917 1.00 44.69  ? 399 THR A OG1 1 
ATOM 2644 C CG2 . THR A 1 478 ? 134.006 148.484 126.164 1.00 45.66  ? 399 THR A CG2 1 
ATOM 2645 N N   . ILE A 1 479 ? 133.965 144.603 124.760 1.00 41.96  ? 400 ILE A N   1 
ATOM 2646 C CA  . ILE A 1 479 ? 133.143 143.958 123.744 1.00 44.06  ? 400 ILE A CA  1 
ATOM 2647 C C   . ILE A 1 479 ? 132.237 142.888 124.354 1.00 45.89  ? 400 ILE A C   1 
ATOM 2648 O O   . ILE A 1 479 ? 131.230 142.512 123.746 1.00 49.84  ? 400 ILE A O   1 
ATOM 2649 C CB  . ILE A 1 479 ? 134.044 143.389 122.626 1.00 38.94  ? 400 ILE A CB  1 
ATOM 2650 C CG1 . ILE A 1 479 ? 133.238 143.088 121.360 1.00 40.06  ? 400 ILE A CG1 1 
ATOM 2651 C CG2 . ILE A 1 479 ? 134.761 142.134 123.088 1.00 41.44  ? 400 ILE A CG2 1 
ATOM 2652 C CD1 . ILE A 1 479 ? 132.706 144.321 120.672 1.00 45.46  ? 400 ILE A CD1 1 
ATOM 2653 N N   . THR A 1 480 ? 132.541 142.406 125.562 1.00 43.43  ? 401 THR A N   1 
ATOM 2654 C CA  . THR A 1 480 ? 131.681 141.397 126.170 1.00 45.55  ? 401 THR A CA  1 
ATOM 2655 C C   . THR A 1 480 ? 130.441 142.013 126.813 1.00 52.46  ? 401 THR A C   1 
ATOM 2656 O O   . THR A 1 480 ? 129.340 141.474 126.664 1.00 53.67  ? 401 THR A O   1 
ATOM 2657 C CB  . THR A 1 480 ? 132.463 140.571 127.191 1.00 43.83  ? 401 THR A CB  1 
ATOM 2658 O OG1 . THR A 1 480 ? 133.295 141.431 127.975 1.00 48.59  ? 401 THR A OG1 1 
ATOM 2659 C CG2 . THR A 1 480 ? 133.328 139.550 126.483 1.00 38.33  ? 401 THR A CG2 1 
ATOM 2660 N N   . LEU A 1 481 ? 130.586 143.131 127.531 1.00 52.56  ? 402 LEU A N   1 
ATOM 2661 C CA  . LEU A 1 481 ? 129.404 143.777 128.093 1.00 49.89  ? 402 LEU A CA  1 
ATOM 2662 C C   . LEU A 1 481 ? 128.640 144.615 127.076 1.00 56.25  ? 402 LEU A C   1 
ATOM 2663 O O   . LEU A 1 481 ? 127.489 144.976 127.345 1.00 61.20  ? 402 LEU A O   1 
ATOM 2664 C CB  . LEU A 1 481 ? 129.749 144.674 129.289 1.00 44.54  ? 402 LEU A CB  1 
ATOM 2665 C CG  . LEU A 1 481 ? 130.730 144.324 130.408 1.00 45.24  ? 402 LEU A CG  1 
ATOM 2666 C CD1 . LEU A 1 481 ? 132.068 144.974 130.186 1.00 44.41  ? 402 LEU A CD1 1 
ATOM 2667 C CD2 . LEU A 1 481 ? 130.164 144.769 131.740 1.00 48.62  ? 402 LEU A CD2 1 
ATOM 2668 N N   . THR A 1 482 ? 129.249 144.954 125.935 1.00 52.46  ? 403 THR A N   1 
ATOM 2669 C CA  . THR A 1 482 ? 128.549 145.772 124.946 1.00 52.82  ? 403 THR A CA  1 
ATOM 2670 C C   . THR A 1 482 ? 127.393 145.009 124.313 1.00 53.63  ? 403 THR A C   1 
ATOM 2671 O O   . THR A 1 482 ? 126.266 145.512 124.250 1.00 52.70  ? 403 THR A O   1 
ATOM 2672 C CB  . THR A 1 482 ? 129.516 146.264 123.870 1.00 55.40  ? 403 THR A CB  1 
ATOM 2673 O OG1 . THR A 1 482 ? 130.659 146.865 124.489 1.00 53.53  ? 403 THR A OG1 1 
ATOM 2674 C CG2 . THR A 1 482 ? 128.836 147.289 122.975 1.00 52.94  ? 403 THR A CG2 1 
ATOM 2675 N N   . LEU A 1 483 ? 127.649 143.790 123.838 1.00 52.92  ? 404 LEU A N   1 
ATOM 2676 C CA  . LEU A 1 483 ? 126.553 142.978 123.312 1.00 65.29  ? 404 LEU A CA  1 
ATOM 2677 C C   . LEU A 1 483 ? 125.813 142.280 124.449 1.00 71.40  ? 404 LEU A C   1 
ATOM 2678 O O   . LEU A 1 483 ? 124.633 142.554 124.694 1.00 73.90  ? 404 LEU A O   1 
ATOM 2679 C CB  . LEU A 1 483 ? 127.077 141.964 122.287 1.00 65.35  ? 404 LEU A CB  1 
ATOM 2680 C CG  . LEU A 1 483 ? 127.755 142.454 120.998 1.00 61.00  ? 404 LEU A CG  1 
ATOM 2681 C CD1 . LEU A 1 483 ? 127.118 143.741 120.481 1.00 61.78  ? 404 LEU A CD1 1 
ATOM 2682 C CD2 . LEU A 1 483 ? 129.261 142.614 121.145 1.00 52.63  ? 404 LEU A CD2 1 
ATOM 2683 N N   . GLN A 1 484 ? 126.488 141.342 125.129 1.00 66.68  ? 405 GLN A N   1 
ATOM 2684 C CA  . GLN A 1 484 ? 126.096 140.763 126.418 1.00 62.80  ? 405 GLN A CA  1 
ATOM 2685 C C   . GLN A 1 484 ? 124.797 139.945 126.337 1.00 70.56  ? 405 GLN A C   1 
ATOM 2686 O O   . GLN A 1 484 ? 124.440 139.224 127.276 1.00 77.58  ? 405 GLN A O   1 
ATOM 2687 C CB  . GLN A 1 484 ? 126.027 141.907 127.455 1.00 60.94  ? 405 GLN A CB  1 
ATOM 2688 C CG  . GLN A 1 484 ? 125.530 141.604 128.865 1.00 59.16  ? 405 GLN A CG  1 
ATOM 2689 C CD  . GLN A 1 484 ? 125.008 142.837 129.569 1.00 61.00  ? 405 GLN A CD  1 
ATOM 2690 O OE1 . GLN A 1 484 ? 124.922 142.873 130.795 1.00 60.50  ? 405 GLN A OE1 1 
ATOM 2691 N NE2 . GLN A 1 484 ? 124.657 143.857 128.795 1.00 60.73  ? 405 GLN A NE2 1 
ATOM 2692 N N   . ASP A 1 485 ? 124.140 139.946 125.178 1.00 72.18  ? 406 ASP A N   1 
ATOM 2693 C CA  . ASP A 1 485 ? 122.832 139.331 125.036 1.00 77.05  ? 406 ASP A CA  1 
ATOM 2694 C C   . ASP A 1 485 ? 122.692 138.517 123.759 1.00 76.98  ? 406 ASP A C   1 
ATOM 2695 O O   . ASP A 1 485 ? 121.607 137.987 123.505 1.00 82.47  ? 406 ASP A O   1 
ATOM 2696 C CB  . ASP A 1 485 ? 121.736 140.410 125.075 1.00 80.08  ? 406 ASP A CB  1 
ATOM 2697 C CG  . ASP A 1 485 ? 120.539 140.000 125.910 1.00 88.10  ? 406 ASP A CG  1 
ATOM 2698 O OD1 . ASP A 1 485 ? 120.463 138.818 126.306 1.00 85.80  ? 406 ASP A OD1 1 
ATOM 2699 O OD2 . ASP A 1 485 ? 119.677 140.865 126.174 1.00 95.87  ? 406 ASP A OD2 1 
ATOM 2700 N N   . HIS A 1 486 ? 123.746 138.402 122.953 1.00 72.77  ? 407 HIS A N   1 
ATOM 2701 C CA  . HIS A 1 486 ? 123.662 137.666 121.700 1.00 75.45  ? 407 HIS A CA  1 
ATOM 2702 C C   . HIS A 1 486 ? 123.711 136.159 121.910 1.00 77.15  ? 407 HIS A C   1 
ATOM 2703 O O   . HIS A 1 486 ? 123.241 135.412 121.046 1.00 82.97  ? 407 HIS A O   1 
ATOM 2704 C CB  . HIS A 1 486 ? 124.797 138.092 120.762 1.00 78.22  ? 407 HIS A CB  1 
ATOM 2705 C CG  . HIS A 1 486 ? 124.675 139.496 120.251 1.00 79.48  ? 407 HIS A CG  1 
ATOM 2706 N ND1 . HIS A 1 486 ? 125.185 139.887 119.031 1.00 77.76  ? 407 HIS A ND1 1 
ATOM 2707 C CD2 . HIS A 1 486 ? 124.111 140.602 120.794 1.00 75.32  ? 407 HIS A CD2 1 
ATOM 2708 C CE1 . HIS A 1 486 ? 124.936 141.171 118.843 1.00 74.45  ? 407 HIS A CE1 1 
ATOM 2709 N NE2 . HIS A 1 486 ? 124.286 141.629 119.898 1.00 73.28  ? 407 HIS A NE2 1 
ATOM 2710 N N   . ALA A 1 487 ? 124.256 135.703 123.037 1.00 71.39  ? 408 ALA A N   1 
ATOM 2711 C CA  . ALA A 1 487 ? 124.393 134.284 123.332 1.00 69.86  ? 408 ALA A CA  1 
ATOM 2712 C C   . ALA A 1 487 ? 124.544 134.125 124.837 1.00 69.66  ? 408 ALA A C   1 
ATOM 2713 O O   . ALA A 1 487 ? 125.068 135.030 125.495 1.00 68.05  ? 408 ALA A O   1 
ATOM 2714 C CB  . ALA A 1 487 ? 125.599 133.681 122.596 1.00 66.93  ? 408 ALA A CB  1 
ATOM 2715 N N   . PRO A 1 488 ? 124.088 133.005 125.413 1.00 73.30  ? 409 PRO A N   1 
ATOM 2716 C CA  . PRO A 1 488 ? 124.200 132.834 126.872 1.00 71.37  ? 409 PRO A CA  1 
ATOM 2717 C C   . PRO A 1 488 ? 125.627 132.698 127.380 1.00 69.51  ? 409 PRO A C   1 
ATOM 2718 O O   . PRO A 1 488 ? 125.853 132.889 128.582 1.00 70.80  ? 409 PRO A O   1 
ATOM 2719 C CB  . PRO A 1 488 ? 123.393 131.556 127.138 1.00 70.68  ? 409 PRO A CB  1 
ATOM 2720 C CG  . PRO A 1 488 ? 123.440 130.814 125.849 1.00 71.96  ? 409 PRO A CG  1 
ATOM 2721 C CD  . PRO A 1 488 ? 123.381 131.872 124.788 1.00 75.66  ? 409 PRO A CD  1 
ATOM 2722 N N   . TRP A 1 489 ? 126.590 132.372 126.523 1.00 66.05  ? 410 TRP A N   1 
ATOM 2723 C CA  . TRP A 1 489 ? 127.983 132.256 126.935 1.00 62.59  ? 410 TRP A CA  1 
ATOM 2724 C C   . TRP A 1 489 ? 128.766 133.555 126.777 1.00 62.07  ? 410 TRP A C   1 
ATOM 2725 O O   . TRP A 1 489 ? 129.946 133.594 127.139 1.00 60.74  ? 410 TRP A O   1 
ATOM 2726 C CB  . TRP A 1 489 ? 128.666 131.126 126.155 1.00 68.38  ? 410 TRP A CB  1 
ATOM 2727 C CG  . TRP A 1 489 ? 128.661 131.315 124.666 1.00 73.07  ? 410 TRP A CG  1 
ATOM 2728 C CD1 . TRP A 1 489 ? 127.646 131.004 123.808 1.00 72.22  ? 410 TRP A CD1 1 
ATOM 2729 C CD2 . TRP A 1 489 ? 129.723 131.834 123.858 1.00 70.94  ? 410 TRP A CD2 1 
ATOM 2730 N NE1 . TRP A 1 489 ? 128.006 131.308 122.518 1.00 70.69  ? 410 TRP A NE1 1 
ATOM 2731 C CE2 . TRP A 1 489 ? 129.276 131.819 122.522 1.00 69.95  ? 410 TRP A CE2 1 
ATOM 2732 C CE3 . TRP A 1 489 ? 131.006 132.315 124.133 1.00 67.40  ? 410 TRP A CE3 1 
ATOM 2733 C CZ2 . TRP A 1 489 ? 130.066 132.266 121.466 1.00 72.83  ? 410 TRP A CZ2 1 
ATOM 2734 C CZ3 . TRP A 1 489 ? 131.787 132.757 123.082 1.00 68.40  ? 410 TRP A CZ3 1 
ATOM 2735 C CH2 . TRP A 1 489 ? 131.315 132.731 121.767 1.00 73.74  ? 410 TRP A CH2 1 
ATOM 2736 N N   . VAL A 1 490 ? 128.141 134.609 126.243 1.00 63.67  ? 411 VAL A N   1 
ATOM 2737 C CA  . VAL A 1 490 ? 128.810 135.913 126.169 1.00 59.40  ? 411 VAL A CA  1 
ATOM 2738 C C   . VAL A 1 490 ? 129.111 136.513 127.543 1.00 59.67  ? 411 VAL A C   1 
ATOM 2739 O O   . VAL A 1 490 ? 130.234 137.006 127.736 1.00 61.78  ? 411 VAL A O   1 
ATOM 2740 C CB  . VAL A 1 490 ? 128.017 136.864 125.252 1.00 59.36  ? 411 VAL A CB  1 
ATOM 2741 C CG1 . VAL A 1 490 ? 128.694 138.220 125.164 1.00 56.51  ? 411 VAL A CG1 1 
ATOM 2742 C CG2 . VAL A 1 490 ? 127.887 136.268 123.870 1.00 66.95  ? 411 VAL A CG2 1 
ATOM 2743 N N   . PRO A 1 491 ? 128.180 136.531 128.523 1.00 60.02  ? 412 PRO A N   1 
ATOM 2744 C CA  . PRO A 1 491 ? 128.569 137.042 129.854 1.00 55.76  ? 412 PRO A CA  1 
ATOM 2745 C C   . PRO A 1 491 ? 129.687 136.261 130.527 1.00 55.71  ? 412 PRO A C   1 
ATOM 2746 O O   . PRO A 1 491 ? 130.464 136.849 131.289 1.00 52.56  ? 412 PRO A O   1 
ATOM 2747 C CB  . PRO A 1 491 ? 127.269 136.947 130.662 1.00 53.71  ? 412 PRO A CB  1 
ATOM 2748 C CG  . PRO A 1 491 ? 126.210 137.061 129.671 1.00 56.14  ? 412 PRO A CG  1 
ATOM 2749 C CD  . PRO A 1 491 ? 126.716 136.312 128.479 1.00 60.20  ? 412 PRO A CD  1 
ATOM 2750 N N   . TYR A 1 492 ? 129.795 134.956 130.270 1.00 58.78  ? 413 TYR A N   1 
ATOM 2751 C CA  . TYR A 1 492 ? 130.860 134.166 130.879 1.00 55.68  ? 413 TYR A CA  1 
ATOM 2752 C C   . TYR A 1 492 ? 132.233 134.508 130.317 1.00 53.39  ? 413 TYR A C   1 
ATOM 2753 O O   . TYR A 1 492 ? 133.242 134.228 130.972 1.00 49.84  ? 413 TYR A O   1 
ATOM 2754 C CB  . TYR A 1 492 ? 130.589 132.668 130.710 1.00 57.62  ? 413 TYR A CB  1 
ATOM 2755 C CG  . TYR A 1 492 ? 129.567 132.086 131.669 1.00 62.52  ? 413 TYR A CG  1 
ATOM 2756 C CD1 . TYR A 1 492 ? 128.314 132.666 131.836 1.00 63.02  ? 413 TYR A CD1 1 
ATOM 2757 C CD2 . TYR A 1 492 ? 129.865 130.953 132.415 1.00 69.12  ? 413 TYR A CD2 1 
ATOM 2758 C CE1 . TYR A 1 492 ? 127.389 132.132 132.712 1.00 70.78  ? 413 TYR A CE1 1 
ATOM 2759 C CE2 . TYR A 1 492 ? 128.947 130.412 133.293 1.00 72.28  ? 413 TYR A CE2 1 
ATOM 2760 C CZ  . TYR A 1 492 ? 127.711 131.005 133.438 1.00 75.00  ? 413 TYR A CZ  1 
ATOM 2761 O OH  . TYR A 1 492 ? 126.796 130.468 134.313 1.00 82.15  ? 413 TYR A OH  1 
ATOM 2762 N N   . LEU A 1 493 ? 132.298 135.096 129.120 1.00 52.81  ? 414 LEU A N   1 
ATOM 2763 C CA  . LEU A 1 493 ? 133.575 135.588 128.618 1.00 50.20  ? 414 LEU A CA  1 
ATOM 2764 C C   . LEU A 1 493 ? 134.057 136.798 129.405 1.00 50.51  ? 414 LEU A C   1 
ATOM 2765 O O   . LEU A 1 493 ? 135.268 137.015 129.521 1.00 53.20  ? 414 LEU A O   1 
ATOM 2766 C CB  . LEU A 1 493 ? 133.472 135.943 127.138 1.00 50.45  ? 414 LEU A CB  1 
ATOM 2767 C CG  . LEU A 1 493 ? 133.331 134.820 126.117 1.00 53.01  ? 414 LEU A CG  1 
ATOM 2768 C CD1 . LEU A 1 493 ? 133.478 135.406 124.727 1.00 62.44  ? 414 LEU A CD1 1 
ATOM 2769 C CD2 . LEU A 1 493 ? 134.364 133.735 126.361 1.00 52.79  ? 414 LEU A CD2 1 
ATOM 2770 N N   . SER A 1 494 ? 133.129 137.599 129.938 1.00 48.71  ? 415 SER A N   1 
ATOM 2771 C CA  . SER A 1 494 ? 133.515 138.753 130.744 1.00 46.88  ? 415 SER A CA  1 
ATOM 2772 C C   . SER A 1 494 ? 134.189 138.331 132.041 1.00 46.36  ? 415 SER A C   1 
ATOM 2773 O O   . SER A 1 494 ? 134.955 139.111 132.618 1.00 47.37  ? 415 SER A O   1 
ATOM 2774 C CB  . SER A 1 494 ? 132.300 139.627 131.043 1.00 50.57  ? 415 SER A CB  1 
ATOM 2775 O OG  . SER A 1 494 ? 132.514 140.393 132.216 1.00 54.54  ? 415 SER A OG  1 
ATOM 2776 N N   . ILE A 1 495 ? 133.902 137.120 132.526 1.00 45.68  ? 416 ILE A N   1 
ATOM 2777 C CA  . ILE A 1 495 ? 134.689 136.555 133.618 1.00 42.60  ? 416 ILE A CA  1 
ATOM 2778 C C   . ILE A 1 495 ? 136.129 136.364 133.170 1.00 44.87  ? 416 ILE A C   1 
ATOM 2779 O O   . ILE A 1 495 ? 137.063 136.893 133.782 1.00 45.76  ? 416 ILE A O   1 
ATOM 2780 C CB  . ILE A 1 495 ? 134.083 135.222 134.089 1.00 41.92  ? 416 ILE A CB  1 
ATOM 2781 C CG1 . ILE A 1 495 ? 132.654 135.406 134.578 1.00 46.80  ? 416 ILE A CG1 1 
ATOM 2782 C CG2 . ILE A 1 495 ? 134.916 134.625 135.199 1.00 37.75  ? 416 ILE A CG2 1 
ATOM 2783 C CD1 . ILE A 1 495 ? 131.964 134.091 134.871 1.00 49.33  ? 416 ILE A CD1 1 
ATOM 2784 N N   . VAL A 1 496 ? 136.316 135.660 132.046 1.00 44.87  ? 417 VAL A N   1 
ATOM 2785 C CA  . VAL A 1 496 ? 137.642 135.299 131.547 1.00 41.11  ? 417 VAL A CA  1 
ATOM 2786 C C   . VAL A 1 496 ? 138.433 136.541 131.160 1.00 41.62  ? 417 VAL A C   1 
ATOM 2787 O O   . VAL A 1 496 ? 139.654 136.600 131.360 1.00 39.89  ? 417 VAL A O   1 
ATOM 2788 C CB  . VAL A 1 496 ? 137.496 134.314 130.367 1.00 37.77  ? 417 VAL A CB  1 
ATOM 2789 C CG1 . VAL A 1 496 ? 138.847 133.960 129.764 1.00 39.92  ? 417 VAL A CG1 1 
ATOM 2790 C CG2 . VAL A 1 496 ? 136.770 133.060 130.817 1.00 40.81  ? 417 VAL A CG2 1 
ATOM 2791 N N   . GLY A 1 497 ? 137.753 137.563 130.640 1.00 41.05  ? 418 GLY A N   1 
ATOM 2792 C CA  . GLY A 1 497 ? 138.401 138.830 130.358 1.00 34.86  ? 418 GLY A CA  1 
ATOM 2793 C C   . GLY A 1 497 ? 138.928 139.542 131.587 1.00 36.41  ? 418 GLY A C   1 
ATOM 2794 O O   . GLY A 1 497 ? 139.833 140.371 131.465 1.00 43.33  ? 418 GLY A O   1 
ATOM 2795 N N   . ILE A 1 498 ? 138.395 139.233 132.767 1.00 35.83  ? 419 ILE A N   1 
ATOM 2796 C CA  . ILE A 1 498 ? 138.847 139.880 133.995 1.00 35.58  ? 419 ILE A CA  1 
ATOM 2797 C C   . ILE A 1 498 ? 140.007 139.127 134.642 1.00 37.60  ? 419 ILE A C   1 
ATOM 2798 O O   . ILE A 1 498 ? 140.964 139.752 135.109 1.00 39.18  ? 419 ILE A O   1 
ATOM 2799 C CB  . ILE A 1 498 ? 137.653 140.069 134.956 1.00 36.43  ? 419 ILE A CB  1 
ATOM 2800 C CG1 . ILE A 1 498 ? 136.830 141.272 134.495 1.00 38.39  ? 419 ILE A CG1 1 
ATOM 2801 C CG2 . ILE A 1 498 ? 138.102 140.260 136.395 1.00 34.82  ? 419 ILE A CG2 1 
ATOM 2802 C CD1 . ILE A 1 498 ? 135.479 141.399 135.129 1.00 37.01  ? 419 ILE A CD1 1 
ATOM 2803 N N   . LEU A 1 499 ? 139.981 137.787 134.664 1.00 37.59  ? 420 LEU A N   1 
ATOM 2804 C CA  . LEU A 1 499 ? 141.154 137.065 135.155 1.00 37.30  ? 420 LEU A CA  1 
ATOM 2805 C C   . LEU A 1 499 ? 142.354 137.238 134.232 1.00 37.67  ? 420 LEU A C   1 
ATOM 2806 O O   . LEU A 1 499 ? 143.498 137.118 134.682 1.00 39.02  ? 420 LEU A O   1 
ATOM 2807 C CB  . LEU A 1 499 ? 140.877 135.569 135.345 1.00 36.36  ? 420 LEU A CB  1 
ATOM 2808 C CG  . LEU A 1 499 ? 139.722 134.967 136.149 1.00 37.21  ? 420 LEU A CG  1 
ATOM 2809 C CD1 . LEU A 1 499 ? 138.589 134.568 135.258 1.00 39.33  ? 420 LEU A CD1 1 
ATOM 2810 C CD2 . LEU A 1 499 ? 140.192 133.761 136.936 1.00 43.21  ? 420 LEU A CD2 1 
ATOM 2811 N N   . ALA A 1 500 ? 142.119 137.513 132.946 1.00 35.19  ? 421 ALA A N   1 
ATOM 2812 C CA  . ALA A 1 500 ? 143.225 137.815 132.044 1.00 33.64  ? 421 ALA A CA  1 
ATOM 2813 C C   . ALA A 1 500 ? 143.873 139.149 132.394 1.00 34.34  ? 421 ALA A C   1 
ATOM 2814 O O   . ALA A 1 500 ? 145.089 139.313 132.243 1.00 36.88  ? 421 ALA A O   1 
ATOM 2815 C CB  . ALA A 1 500 ? 142.737 137.815 130.597 1.00 33.26  ? 421 ALA A CB  1 
ATOM 2816 N N   . ILE A 1 501 ? 143.074 140.118 132.846 1.00 32.48  ? 422 ILE A N   1 
ATOM 2817 C CA  . ILE A 1 501 ? 143.624 141.383 133.322 1.00 33.73  ? 422 ILE A CA  1 
ATOM 2818 C C   . ILE A 1 501 ? 144.412 141.174 134.610 1.00 38.05  ? 422 ILE A C   1 
ATOM 2819 O O   . ILE A 1 501 ? 145.516 141.708 134.774 1.00 42.77  ? 422 ILE A O   1 
ATOM 2820 C CB  . ILE A 1 501 ? 142.491 142.411 133.505 1.00 33.48  ? 422 ILE A CB  1 
ATOM 2821 C CG1 . ILE A 1 501 ? 141.955 142.859 132.148 1.00 33.84  ? 422 ILE A CG1 1 
ATOM 2822 C CG2 . ILE A 1 501 ? 142.958 143.614 134.306 1.00 35.59  ? 422 ILE A CG2 1 
ATOM 2823 C CD1 . ILE A 1 501 ? 140.579 143.460 132.215 1.00 33.44  ? 422 ILE A CD1 1 
ATOM 2824 N N   . ILE A 1 502 ? 143.866 140.378 135.533 1.00 36.67  ? 423 ILE A N   1 
ATOM 2825 C CA  . ILE A 1 502 ? 144.495 140.168 136.834 1.00 37.12  ? 423 ILE A CA  1 
ATOM 2826 C C   . ILE A 1 502 ? 145.801 139.392 136.687 1.00 41.68  ? 423 ILE A C   1 
ATOM 2827 O O   . ILE A 1 502 ? 146.800 139.704 137.348 1.00 44.92  ? 423 ILE A O   1 
ATOM 2828 C CB  . ILE A 1 502 ? 143.504 139.463 137.778 1.00 35.24  ? 423 ILE A CB  1 
ATOM 2829 C CG1 . ILE A 1 502 ? 142.317 140.381 138.063 1.00 34.53  ? 423 ILE A CG1 1 
ATOM 2830 C CG2 . ILE A 1 502 ? 144.168 139.071 139.084 1.00 39.74  ? 423 ILE A CG2 1 
ATOM 2831 C CD1 . ILE A 1 502 ? 141.181 139.701 138.769 1.00 34.87  ? 423 ILE A CD1 1 
ATOM 2832 N N   . ALA A 1 503 ? 145.820 138.383 135.811 1.00 38.27  ? 424 ALA A N   1 
ATOM 2833 C CA  . ALA A 1 503 ? 147.049 137.633 135.565 1.00 38.96  ? 424 ALA A CA  1 
ATOM 2834 C C   . ALA A 1 503 ? 148.119 138.499 134.913 1.00 47.54  ? 424 ALA A C   1 
ATOM 2835 O O   . ALA A 1 503 ? 149.315 138.281 135.138 1.00 51.93  ? 424 ALA A O   1 
ATOM 2836 C CB  . ALA A 1 503 ? 146.758 136.413 134.694 1.00 37.50  ? 424 ALA A CB  1 
ATOM 2837 N N   . SER A 1 504 ? 147.712 139.476 134.100 1.00 45.94  ? 425 SER A N   1 
ATOM 2838 C CA  . SER A 1 504 ? 148.674 140.397 133.504 1.00 44.73  ? 425 SER A CA  1 
ATOM 2839 C C   . SER A 1 504 ? 149.286 141.326 134.545 1.00 49.93  ? 425 SER A C   1 
ATOM 2840 O O   . SER A 1 504 ? 150.450 141.720 134.409 1.00 55.18  ? 425 SER A O   1 
ATOM 2841 C CB  . SER A 1 504 ? 148.005 141.211 132.398 1.00 37.78  ? 425 SER A CB  1 
ATOM 2842 O OG  . SER A 1 504 ? 147.506 140.366 131.378 1.00 39.44  ? 425 SER A OG  1 
ATOM 2843 N N   . PHE A 1 505 ? 148.519 141.698 135.573 1.00 47.52  ? 426 PHE A N   1 
ATOM 2844 C CA  . PHE A 1 505 ? 149.032 142.585 136.612 1.00 48.91  ? 426 PHE A CA  1 
ATOM 2845 C C   . PHE A 1 505 ? 150.121 141.905 137.430 1.00 53.86  ? 426 PHE A C   1 
ATOM 2846 O O   . PHE A 1 505 ? 151.196 142.476 137.646 1.00 58.80  ? 426 PHE A O   1 
ATOM 2847 C CB  . PHE A 1 505 ? 147.885 143.040 137.519 1.00 53.51  ? 426 PHE A CB  1 
ATOM 2848 C CG  . PHE A 1 505 ? 148.312 143.919 138.672 1.00 53.24  ? 426 PHE A CG  1 
ATOM 2849 C CD1 . PHE A 1 505 ? 148.363 145.296 138.521 1.00 53.17  ? 426 PHE A CD1 1 
ATOM 2850 C CD2 . PHE A 1 505 ? 148.624 143.376 139.914 1.00 53.35  ? 426 PHE A CD2 1 
ATOM 2851 C CE1 . PHE A 1 505 ? 148.738 146.108 139.570 1.00 54.66  ? 426 PHE A CE1 1 
ATOM 2852 C CE2 . PHE A 1 505 ? 149.000 144.185 140.965 1.00 54.03  ? 426 PHE A CE2 1 
ATOM 2853 C CZ  . PHE A 1 505 ? 149.055 145.551 140.793 1.00 56.19  ? 426 PHE A CZ  1 
ATOM 2854 N N   . CYS A 1 506 ? 149.844 140.693 137.918 1.00 52.49  ? 427 CYS A N   1 
ATOM 2855 C CA  . CYS A 1 506 ? 150.762 140.023 138.835 1.00 57.90  ? 427 CYS A CA  1 
ATOM 2856 C C   . CYS A 1 506 ? 152.068 139.649 138.146 1.00 67.11  ? 427 CYS A C   1 
ATOM 2857 O O   . CYS A 1 506 ? 153.146 139.782 138.737 1.00 72.15  ? 427 CYS A O   1 
ATOM 2858 C CB  . CYS A 1 506 ? 150.093 138.786 139.429 1.00 60.37  ? 427 CYS A CB  1 
ATOM 2859 S SG  . CYS A 1 506 ? 148.558 139.138 140.311 1.00 76.83  ? 427 CYS A SG  1 
ATOM 2860 N N   . SER A 1 507 ? 151.990 139.182 136.899 1.00 65.97  ? 428 SER A N   1 
ATOM 2861 C CA  . SER A 1 507 ? 153.199 138.850 136.154 1.00 65.87  ? 428 SER A CA  1 
ATOM 2862 C C   . SER A 1 507 ? 154.009 140.099 135.825 1.00 64.03  ? 428 SER A C   1 
ATOM 2863 O O   . SER A 1 507 ? 155.242 140.086 135.910 1.00 65.48  ? 428 SER A O   1 
ATOM 2864 C CB  . SER A 1 507 ? 152.831 138.094 134.879 1.00 62.72  ? 428 SER A CB  1 
ATOM 2865 O OG  . SER A 1 507 ? 152.037 136.958 135.173 1.00 65.22  ? 428 SER A OG  1 
ATOM 2866 N N   . GLY A 1 508 ? 153.338 141.190 135.471 1.00 60.04  ? 429 GLY A N   1 
ATOM 2867 C CA  . GLY A 1 508 ? 154.010 142.378 135.005 1.00 55.78  ? 429 GLY A CA  1 
ATOM 2868 C C   . GLY A 1 508 ? 154.134 143.458 136.059 1.00 55.31  ? 429 GLY A C   1 
ATOM 2869 O O   . GLY A 1 508 ? 155.019 143.423 136.918 1.00 55.69  ? 429 GLY A O   1 
ATOM 2870 N N   . PRO A 1 509 ? 153.230 144.449 136.014 1.00 57.38  ? 430 PRO A N   1 
ATOM 2871 C CA  . PRO A 1 509 ? 153.364 145.644 136.867 1.00 55.57  ? 430 PRO A CA  1 
ATOM 2872 C C   . PRO A 1 509 ? 153.198 145.426 138.369 1.00 56.18  ? 430 PRO A C   1 
ATOM 2873 O O   . PRO A 1 509 ? 153.132 146.410 139.111 1.00 56.40  ? 430 PRO A O   1 
ATOM 2874 C CB  . PRO A 1 509 ? 152.253 146.567 136.347 1.00 51.21  ? 430 PRO A CB  1 
ATOM 2875 C CG  . PRO A 1 509 ? 151.938 146.089 134.987 1.00 50.96  ? 430 PRO A CG  1 
ATOM 2876 C CD  . PRO A 1 509 ? 152.208 144.621 134.968 1.00 55.60  ? 430 PRO A CD  1 
ATOM 2877 N N   . GLY A 1 510 ? 153.095 144.174 138.823 1.00 56.27  ? 431 GLY A N   1 
ATOM 2878 C CA  . GLY A 1 510 ? 152.799 143.913 140.225 1.00 55.50  ? 431 GLY A CA  1 
ATOM 2879 C C   . GLY A 1 510 ? 153.867 144.407 141.184 1.00 61.56  ? 431 GLY A C   1 
ATOM 2880 O O   . GLY A 1 510 ? 153.553 144.942 142.250 1.00 64.91  ? 431 GLY A O   1 
ATOM 2881 N N   . GLY A 1 511 ? 155.138 144.240 140.825 1.00 63.08  ? 432 GLY A N   1 
ATOM 2882 C CA  . GLY A 1 511 ? 156.211 144.615 141.729 1.00 62.91  ? 432 GLY A CA  1 
ATOM 2883 C C   . GLY A 1 511 ? 157.368 145.348 141.084 1.00 60.96  ? 432 GLY A C   1 
ATOM 2884 O O   . GLY A 1 511 ? 158.414 145.544 141.709 1.00 61.40  ? 432 GLY A O   1 
ATOM 2885 N N   . ILE A 1 512 ? 157.193 145.752 139.831 1.00 62.31  ? 433 ILE A N   1 
ATOM 2886 C CA  . ILE A 1 512 ? 158.214 146.483 139.080 1.00 65.79  ? 433 ILE A CA  1 
ATOM 2887 C C   . ILE A 1 512 ? 158.246 147.981 139.405 1.00 69.40  ? 433 ILE A C   1 
ATOM 2888 O O   . ILE A 1 512 ? 159.357 148.521 139.534 1.00 71.58  ? 433 ILE A O   1 
ATOM 2889 C CB  . ILE A 1 512 ? 158.052 146.227 137.570 1.00 61.92  ? 433 ILE A CB  1 
ATOM 2890 C CG1 . ILE A 1 512 ? 158.257 144.747 137.282 1.00 57.65  ? 433 ILE A CG1 1 
ATOM 2891 C CG2 . ILE A 1 512 ? 159.060 147.013 136.754 1.00 61.69  ? 433 ILE A CG2 1 
ATOM 2892 C CD1 . ILE A 1 512 ? 158.007 144.383 135.862 1.00 55.43  ? 433 ILE A CD1 1 
ATOM 2893 N N   . PRO A 1 513 ? 157.115 148.710 139.538 1.00 67.62  ? 434 PRO A N   1 
ATOM 2894 C CA  . PRO A 1 513 ? 157.225 150.130 139.937 1.00 67.39  ? 434 PRO A CA  1 
ATOM 2895 C C   . PRO A 1 513 ? 157.915 150.358 141.271 1.00 69.34  ? 434 PRO A C   1 
ATOM 2896 O O   . PRO A 1 513 ? 158.589 151.382 141.442 1.00 70.03  ? 434 PRO A O   1 
ATOM 2897 C CB  . PRO A 1 513 ? 155.763 150.587 139.992 1.00 63.96  ? 434 PRO A CB  1 
ATOM 2898 C CG  . PRO A 1 513 ? 155.098 149.764 138.996 1.00 61.30  ? 434 PRO A CG  1 
ATOM 2899 C CD  . PRO A 1 513 ? 155.723 148.417 139.124 1.00 63.40  ? 434 PRO A CD  1 
ATOM 2900 N N   . PHE A 1 514 ? 157.767 149.435 142.222 1.00 68.49  ? 435 PHE A N   1 
ATOM 2901 C CA  . PHE A 1 514 ? 158.485 149.552 143.486 1.00 69.83  ? 435 PHE A CA  1 
ATOM 2902 C C   . PHE A 1 514 ? 159.979 149.315 143.300 1.00 69.20  ? 435 PHE A C   1 
ATOM 2903 O O   . PHE A 1 514 ? 160.801 149.962 143.959 1.00 70.21  ? 435 PHE A O   1 
ATOM 2904 C CB  . PHE A 1 514 ? 157.904 148.571 144.502 1.00 70.48  ? 435 PHE A CB  1 
ATOM 2905 C CG  . PHE A 1 514 ? 156.404 148.583 144.558 1.00 73.35  ? 435 PHE A CG  1 
ATOM 2906 C CD1 . PHE A 1 514 ? 155.728 149.674 145.079 1.00 73.56  ? 435 PHE A CD1 1 
ATOM 2907 C CD2 . PHE A 1 514 ? 155.670 147.513 144.075 1.00 71.75  ? 435 PHE A CD2 1 
ATOM 2908 C CE1 . PHE A 1 514 ? 154.347 149.693 145.129 1.00 71.90  ? 435 PHE A CE1 1 
ATOM 2909 C CE2 . PHE A 1 514 ? 154.288 147.527 144.121 1.00 70.22  ? 435 PHE A CE2 1 
ATOM 2910 C CZ  . PHE A 1 514 ? 153.627 148.618 144.649 1.00 70.82  ? 435 PHE A CZ  1 
ATOM 2911 N N   . ILE A 1 515 ? 160.350 148.395 142.408 1.00 68.91  ? 436 ILE A N   1 
ATOM 2912 C CA  . ILE A 1 515 ? 161.759 148.070 142.213 1.00 68.04  ? 436 ILE A CA  1 
ATOM 2913 C C   . ILE A 1 515 ? 162.441 148.990 141.203 1.00 68.08  ? 436 ILE A C   1 
ATOM 2914 O O   . ILE A 1 515 ? 163.678 149.054 141.175 1.00 72.34  ? 436 ILE A O   1 
ATOM 2915 C CB  . ILE A 1 515 ? 161.915 146.590 141.807 1.00 69.18  ? 436 ILE A CB  1 
ATOM 2916 C CG1 . ILE A 1 515 ? 163.246 146.029 142.311 1.00 68.32  ? 436 ILE A CG1 1 
ATOM 2917 C CG2 . ILE A 1 515 ? 161.806 146.405 140.300 1.00 69.49  ? 436 ILE A CG2 1 
ATOM 2918 C CD1 . ILE A 1 515 ? 163.316 144.519 142.286 1.00 62.55  ? 436 ILE A CD1 1 
ATOM 2919 N N   . LEU A 1 516 ? 161.676 149.709 140.377 1.00 68.68  ? 437 LEU A N   1 
ATOM 2920 C CA  . LEU A 1 516 ? 162.283 150.685 139.477 1.00 72.32  ? 437 LEU A CA  1 
ATOM 2921 C C   . LEU A 1 516 ? 162.693 151.956 140.208 1.00 72.19  ? 437 LEU A C   1 
ATOM 2922 O O   . LEU A 1 516 ? 163.760 152.510 139.928 1.00 73.56  ? 437 LEU A O   1 
ATOM 2923 C CB  . LEU A 1 516 ? 161.331 151.031 138.334 1.00 71.76  ? 437 LEU A CB  1 
ATOM 2924 C CG  . LEU A 1 516 ? 161.176 150.025 137.199 1.00 72.01  ? 437 LEU A CG  1 
ATOM 2925 C CD1 . LEU A 1 516 ? 160.218 150.573 136.161 1.00 68.26  ? 437 LEU A CD1 1 
ATOM 2926 C CD2 . LEU A 1 516 ? 162.525 149.704 136.579 1.00 74.09  ? 437 LEU A CD2 1 
ATOM 2927 N N   . THR A 1 517 ? 161.856 152.422 141.144 1.00 71.60  ? 438 THR A N   1 
ATOM 2928 C CA  . THR A 1 517 ? 162.087 153.698 141.818 1.00 70.01  ? 438 THR A CA  1 
ATOM 2929 C C   . THR A 1 517 ? 163.394 153.694 142.603 1.00 72.23  ? 438 THR A C   1 
ATOM 2930 O O   . THR A 1 517 ? 164.089 154.715 142.664 1.00 76.66  ? 438 THR A O   1 
ATOM 2931 C CB  . THR A 1 517 ? 160.901 154.015 142.734 1.00 68.82  ? 438 THR A CB  1 
ATOM 2932 O OG1 . THR A 1 517 ? 159.688 153.975 141.972 1.00 65.24  ? 438 THR A OG1 1 
ATOM 2933 C CG2 . THR A 1 517 ? 161.036 155.398 143.355 1.00 72.27  ? 438 THR A CG2 1 
ATOM 2934 N N   . GLY A 1 518 ? 163.770 152.550 143.161 1.00 73.12  ? 439 GLY A N   1 
ATOM 2935 C CA  . GLY A 1 518 ? 165.060 152.414 143.798 1.00 77.01  ? 439 GLY A CA  1 
ATOM 2936 C C   . GLY A 1 518 ? 166.217 152.172 142.859 1.00 75.36  ? 439 GLY A C   1 
ATOM 2937 O O   . GLY A 1 518 ? 167.349 152.003 143.320 1.00 79.91  ? 439 GLY A O   1 
ATOM 2938 N N   . GLU A 1 519 ? 165.974 152.146 141.551 1.00 73.27  ? 440 GLU A N   1 
ATOM 2939 C CA  . GLU A 1 519 ? 167.015 151.878 140.566 1.00 73.81  ? 440 GLU A CA  1 
ATOM 2940 C C   . GLU A 1 519 ? 167.412 153.096 139.746 1.00 75.30  ? 440 GLU A C   1 
ATOM 2941 O O   . GLU A 1 519 ? 168.583 153.221 139.380 1.00 77.14  ? 440 GLU A O   1 
ATOM 2942 C CB  . GLU A 1 519 ? 166.569 150.756 139.623 1.00 76.34  ? 440 GLU A CB  1 
ATOM 2943 C CG  . GLU A 1 519 ? 167.126 149.393 139.995 1.00 78.13  ? 440 GLU A CG  1 
ATOM 2944 C CD  . GLU A 1 519 ? 166.753 148.321 138.994 1.00 81.31  ? 440 GLU A CD  1 
ATOM 2945 O OE1 . GLU A 1 519 ? 166.208 148.672 137.928 1.00 80.52  ? 440 GLU A OE1 1 
ATOM 2946 O OE2 . GLU A 1 519 ? 167.005 147.130 139.271 1.00 81.32  ? 440 GLU A OE2 1 
ATOM 2947 N N   . PHE A 1 520 ? 166.475 153.996 139.431 1.00 75.46  ? 441 PHE A N   1 
ATOM 2948 C CA  . PHE A 1 520 ? 166.851 155.216 138.722 1.00 74.73  ? 441 PHE A CA  1 
ATOM 2949 C C   . PHE A 1 520 ? 167.652 156.156 139.611 1.00 80.53  ? 441 PHE A C   1 
ATOM 2950 O O   . PHE A 1 520 ? 168.529 156.875 139.120 1.00 81.22  ? 441 PHE A O   1 
ATOM 2951 C CB  . PHE A 1 520 ? 165.622 155.965 138.203 1.00 71.34  ? 441 PHE A CB  1 
ATOM 2952 C CG  . PHE A 1 520 ? 164.743 155.157 137.301 1.00 70.34  ? 441 PHE A CG  1 
ATOM 2953 C CD1 . PHE A 1 520 ? 165.096 154.931 135.984 1.00 76.88  ? 441 PHE A CD1 1 
ATOM 2954 C CD2 . PHE A 1 520 ? 163.523 154.689 137.750 1.00 69.40  ? 441 PHE A CD2 1 
ATOM 2955 C CE1 . PHE A 1 520 ? 164.274 154.200 135.150 1.00 77.10  ? 441 PHE A CE1 1 
ATOM 2956 C CE2 . PHE A 1 520 ? 162.698 153.963 136.921 1.00 70.95  ? 441 PHE A CE2 1 
ATOM 2957 C CZ  . PHE A 1 520 ? 163.073 153.719 135.621 1.00 73.09  ? 441 PHE A CZ  1 
ATOM 2958 N N   . PHE A 1 521 ? 167.357 156.175 140.905 1.00 79.93  ? 442 PHE A N   1 
ATOM 2959 C CA  . PHE A 1 521 ? 167.874 157.175 141.824 1.00 80.88  ? 442 PHE A CA  1 
ATOM 2960 C C   . PHE A 1 521 ? 168.999 156.602 142.677 1.00 82.96  ? 442 PHE A C   1 
ATOM 2961 O O   . PHE A 1 521 ? 169.031 155.405 142.975 1.00 80.26  ? 442 PHE A O   1 
ATOM 2962 C CB  . PHE A 1 521 ? 166.750 157.698 142.720 1.00 79.75  ? 442 PHE A CB  1 
ATOM 2963 C CG  . PHE A 1 521 ? 165.684 158.450 141.976 1.00 75.95  ? 442 PHE A CG  1 
ATOM 2964 C CD1 . PHE A 1 521 ? 165.813 159.807 141.733 1.00 80.59  ? 442 PHE A CD1 1 
ATOM 2965 C CD2 . PHE A 1 521 ? 164.563 157.794 141.500 1.00 71.23  ? 442 PHE A CD2 1 
ATOM 2966 C CE1 . PHE A 1 521 ? 164.832 160.499 141.046 1.00 80.50  ? 442 PHE A CE1 1 
ATOM 2967 C CE2 . PHE A 1 521 ? 163.581 158.479 140.814 1.00 74.24  ? 442 PHE A CE2 1 
ATOM 2968 C CZ  . PHE A 1 521 ? 163.716 159.832 140.585 1.00 78.24  ? 442 PHE A CZ  1 
ATOM 2969 N N   . GLN A 1 522 ? 169.926 157.474 143.066 1.00 87.83  ? 443 GLN A N   1 
ATOM 2970 C CA  . GLN A 1 522 ? 171.049 157.089 143.904 1.00 91.49  ? 443 GLN A CA  1 
ATOM 2971 C C   . GLN A 1 522 ? 170.621 157.038 145.371 1.00 94.54  ? 443 GLN A C   1 
ATOM 2972 O O   . GLN A 1 522 ? 169.462 157.281 145.717 1.00 93.26  ? 443 GLN A O   1 
ATOM 2973 C CB  . GLN A 1 522 ? 172.218 158.047 143.683 1.00 89.76  ? 443 GLN A CB  1 
ATOM 2974 C CG  . GLN A 1 522 ? 172.001 159.432 144.257 1.00 94.08  ? 443 GLN A CG  1 
ATOM 2975 C CD  . GLN A 1 522 ? 173.137 160.383 143.936 1.00 99.36  ? 443 GLN A CD  1 
ATOM 2976 O OE1 . GLN A 1 522 ? 174.005 160.638 144.770 1.00 101.69 ? 443 GLN A OE1 1 
ATOM 2977 N NE2 . GLN A 1 522 ? 173.137 160.913 142.718 1.00 98.18  ? 443 GLN A NE2 1 
ATOM 2978 N N   . GLN A 1 523 ? 171.576 156.712 146.249 1.00 98.85  ? 444 GLN A N   1 
ATOM 2979 C CA  . GLN A 1 523 ? 171.252 156.481 147.656 1.00 99.41  ? 444 GLN A CA  1 
ATOM 2980 C C   . GLN A 1 523 ? 170.840 157.769 148.359 1.00 94.35  ? 444 GLN A C   1 
ATOM 2981 O O   . GLN A 1 523 ? 169.980 157.749 149.247 1.00 91.91  ? 444 GLN A O   1 
ATOM 2982 C CB  . GLN A 1 523 ? 172.437 155.830 148.366 1.00 107.88 ? 444 GLN A CB  1 
ATOM 2983 C CG  . GLN A 1 523 ? 172.052 155.053 149.614 1.00 111.70 ? 444 GLN A CG  1 
ATOM 2984 C CD  . GLN A 1 523 ? 172.882 153.799 149.798 1.00 114.66 ? 444 GLN A CD  1 
ATOM 2985 O OE1 . GLN A 1 523 ? 172.879 152.909 148.947 1.00 111.89 ? 444 GLN A OE1 1 
ATOM 2986 N NE2 . GLN A 1 523 ? 173.596 153.720 150.916 1.00 119.22 ? 444 GLN A NE2 1 
ATOM 2987 N N   . SER A 1 524 ? 171.429 158.900 147.970 1.00 94.86  ? 445 SER A N   1 
ATOM 2988 C CA  . SER A 1 524 ? 171.002 160.177 148.521 1.00 98.97  ? 445 SER A CA  1 
ATOM 2989 C C   . SER A 1 524 ? 169.660 160.642 147.968 1.00 97.42  ? 445 SER A C   1 
ATOM 2990 O O   . SER A 1 524 ? 169.091 161.601 148.501 1.00 100.62 ? 445 SER A O   1 
ATOM 2991 C CB  . SER A 1 524 ? 172.071 161.243 148.264 1.00 104.17 ? 445 SER A CB  1 
ATOM 2992 O OG  . SER A 1 524 ? 172.410 161.315 146.891 1.00 101.33 ? 445 SER A OG  1 
ATOM 2993 N N   . GLN A 1 525 ? 169.135 159.988 146.930 1.00 93.95  ? 446 GLN A N   1 
ATOM 2994 C CA  . GLN A 1 525 ? 167.875 160.388 146.318 1.00 91.11  ? 446 GLN A CA  1 
ATOM 2995 C C   . GLN A 1 525 ? 166.750 159.379 146.504 1.00 85.79  ? 446 GLN A C   1 
ATOM 2996 O O   . GLN A 1 525 ? 165.599 159.712 146.208 1.00 80.73  ? 446 GLN A O   1 
ATOM 2997 C CB  . GLN A 1 525 ? 168.077 160.637 144.817 1.00 91.97  ? 446 GLN A CB  1 
ATOM 2998 C CG  . GLN A 1 525 ? 168.525 162.043 144.486 1.00 96.24  ? 446 GLN A CG  1 
ATOM 2999 C CD  . GLN A 1 525 ? 169.302 162.115 143.188 1.00 93.71  ? 446 GLN A CD  1 
ATOM 3000 O OE1 . GLN A 1 525 ? 169.515 161.102 142.522 1.00 89.77  ? 446 GLN A OE1 1 
ATOM 3001 N NE2 . GLN A 1 525 ? 169.738 163.315 142.825 1.00 92.20  ? 446 GLN A NE2 1 
ATOM 3002 N N   . ARG A 1 526 ? 167.052 158.161 146.967 1.00 87.60  ? 447 ARG A N   1 
ATOM 3003 C CA  . ARG A 1 526 ? 166.018 157.140 147.141 1.00 82.74  ? 447 ARG A CA  1 
ATOM 3004 C C   . ARG A 1 526 ? 164.924 157.501 148.148 1.00 85.72  ? 447 ARG A C   1 
ATOM 3005 O O   . ARG A 1 526 ? 163.741 157.340 147.799 1.00 84.67  ? 447 ARG A O   1 
ATOM 3006 C CB  . ARG A 1 526 ? 166.669 155.793 147.480 1.00 82.23  ? 447 ARG A CB  1 
ATOM 3007 C CG  . ARG A 1 526 ? 167.089 154.973 146.267 1.00 81.63  ? 447 ARG A CG  1 
ATOM 3008 C CD  . ARG A 1 526 ? 167.230 153.500 146.643 1.00 79.79  ? 447 ARG A CD  1 
ATOM 3009 N NE  . ARG A 1 526 ? 168.054 152.723 145.722 1.00 81.25  ? 447 ARG A NE  1 
ATOM 3010 C CZ  . ARG A 1 526 ? 169.371 152.822 145.592 1.00 84.86  ? 447 ARG A CZ  1 
ATOM 3011 N NH1 . ARG A 1 526 ? 170.084 153.641 146.343 1.00 87.95  ? 447 ARG A NH1 1 
ATOM 3012 N NH2 . ARG A 1 526 ? 169.991 152.065 144.692 1.00 84.70  ? 447 ARG A NH2 1 
ATOM 3013 N N   . PRO A 1 527 ? 165.206 157.950 149.387 1.00 89.69  ? 448 PRO A N   1 
ATOM 3014 C CA  . PRO A 1 527 ? 164.086 158.322 150.271 1.00 86.51  ? 448 PRO A CA  1 
ATOM 3015 C C   . PRO A 1 527 ? 163.320 159.543 149.798 1.00 84.66  ? 448 PRO A C   1 
ATOM 3016 O O   . PRO A 1 527 ? 162.147 159.697 150.162 1.00 80.77  ? 448 PRO A O   1 
ATOM 3017 C CB  . PRO A 1 527 ? 164.764 158.575 151.623 1.00 90.02  ? 448 PRO A CB  1 
ATOM 3018 C CG  . PRO A 1 527 ? 166.127 158.972 151.283 1.00 87.92  ? 448 PRO A CG  1 
ATOM 3019 C CD  . PRO A 1 527 ? 166.498 158.188 150.065 1.00 90.72  ? 448 PRO A CD  1 
ATOM 3020 N N   . ALA A 1 528 ? 163.937 160.405 148.993 1.00 86.87  ? 449 ALA A N   1 
ATOM 3021 C CA  . ALA A 1 528 ? 163.224 161.514 148.377 1.00 87.64  ? 449 ALA A CA  1 
ATOM 3022 C C   . ALA A 1 528 ? 162.488 161.110 147.109 1.00 83.08  ? 449 ALA A C   1 
ATOM 3023 O O   . ALA A 1 528 ? 161.741 161.926 146.563 1.00 81.92  ? 449 ALA A O   1 
ATOM 3024 C CB  . ALA A 1 528 ? 164.191 162.654 148.056 1.00 93.59  ? 449 ALA A CB  1 
ATOM 3025 N N   . ALA A 1 529 ? 162.684 159.885 146.626 1.00 81.85  ? 450 ALA A N   1 
ATOM 3026 C CA  . ALA A 1 529 ? 161.997 159.391 145.440 1.00 79.94  ? 450 ALA A CA  1 
ATOM 3027 C C   . ALA A 1 529 ? 160.811 158.502 145.773 1.00 75.84  ? 450 ALA A C   1 
ATOM 3028 O O   . ALA A 1 529 ? 159.797 158.543 145.071 1.00 73.45  ? 450 ALA A O   1 
ATOM 3029 C CB  . ALA A 1 529 ? 162.969 158.619 144.547 1.00 82.95  ? 450 ALA A CB  1 
ATOM 3030 N N   . PHE A 1 530 ? 160.923 157.688 146.826 1.00 75.83  ? 451 PHE A N   1 
ATOM 3031 C CA  . PHE A 1 530 ? 159.800 156.856 147.244 1.00 73.89  ? 451 PHE A CA  1 
ATOM 3032 C C   . PHE A 1 530 ? 158.650 157.691 147.789 1.00 71.55  ? 451 PHE A C   1 
ATOM 3033 O O   . PHE A 1 530 ? 157.495 157.257 147.732 1.00 68.84  ? 451 PHE A O   1 
ATOM 3034 C CB  . PHE A 1 530 ? 160.256 155.843 148.293 1.00 76.58  ? 451 PHE A CB  1 
ATOM 3035 C CG  . PHE A 1 530 ? 161.049 154.700 147.729 1.00 75.94  ? 451 PHE A CG  1 
ATOM 3036 C CD1 . PHE A 1 530 ? 160.539 153.930 146.697 1.00 73.69  ? 451 PHE A CD1 1 
ATOM 3037 C CD2 . PHE A 1 530 ? 162.301 154.393 148.234 1.00 79.47  ? 451 PHE A CD2 1 
ATOM 3038 C CE1 . PHE A 1 530 ? 161.266 152.874 146.177 1.00 69.24  ? 451 PHE A CE1 1 
ATOM 3039 C CE2 . PHE A 1 530 ? 163.033 153.340 147.718 1.00 77.46  ? 451 PHE A CE2 1 
ATOM 3040 C CZ  . PHE A 1 530 ? 162.514 152.580 146.688 1.00 73.11  ? 451 PHE A CZ  1 
ATOM 3041 N N   . ILE A 1 531 ? 158.943 158.877 148.327 1.00 74.00  ? 452 ILE A N   1 
ATOM 3042 C CA  . ILE A 1 531 ? 157.883 159.725 148.864 1.00 69.61  ? 452 ILE A CA  1 
ATOM 3043 C C   . ILE A 1 531 ? 157.029 160.307 147.740 1.00 64.51  ? 452 ILE A C   1 
ATOM 3044 O O   . ILE A 1 531 ? 155.802 160.383 147.863 1.00 63.77  ? 452 ILE A O   1 
ATOM 3045 C CB  . ILE A 1 531 ? 158.475 160.812 149.787 1.00 71.41  ? 452 ILE A CB  1 
ATOM 3046 C CG1 . ILE A 1 531 ? 157.367 161.688 150.381 1.00 71.46  ? 452 ILE A CG1 1 
ATOM 3047 C CG2 . ILE A 1 531 ? 159.548 161.635 149.087 1.00 75.63  ? 452 ILE A CG2 1 
ATOM 3048 C CD1 . ILE A 1 531 ? 156.356 160.921 151.200 1.00 68.74  ? 452 ILE A CD1 1 
ATOM 3049 N N   . ILE A 1 532 ? 157.648 160.711 146.625 1.00 63.71  ? 453 ILE A N   1 
ATOM 3050 C CA  . ILE A 1 532 ? 156.861 161.142 145.472 1.00 64.81  ? 453 ILE A CA  1 
ATOM 3051 C C   . ILE A 1 532 ? 156.149 159.955 144.844 1.00 64.04  ? 453 ILE A C   1 
ATOM 3052 O O   . ILE A 1 532 ? 155.018 160.080 144.362 1.00 62.34  ? 453 ILE A O   1 
ATOM 3053 C CB  . ILE A 1 532 ? 157.729 161.881 144.438 1.00 72.61  ? 453 ILE A CB  1 
ATOM 3054 C CG1 . ILE A 1 532 ? 158.869 162.636 145.109 1.00 74.44  ? 453 ILE A CG1 1 
ATOM 3055 C CG2 . ILE A 1 532 ? 156.877 162.833 143.613 1.00 72.85  ? 453 ILE A CG2 1 
ATOM 3056 C CD1 . ILE A 1 532 ? 159.905 163.102 144.127 1.00 72.05  ? 453 ILE A CD1 1 
ATOM 3057 N N   . ALA A 1 533 ? 156.804 158.793 144.819 1.00 63.79  ? 454 ALA A N   1 
ATOM 3058 C CA  . ALA A 1 533 ? 156.123 157.573 144.408 1.00 61.34  ? 454 ALA A CA  1 
ATOM 3059 C C   . ALA A 1 533 ? 155.027 157.192 145.392 1.00 60.49  ? 454 ALA A C   1 
ATOM 3060 O O   . ALA A 1 533 ? 154.009 156.619 144.992 1.00 57.62  ? 454 ALA A O   1 
ATOM 3061 C CB  . ALA A 1 533 ? 157.126 156.430 144.263 1.00 62.40  ? 454 ALA A CB  1 
ATOM 3062 N N   . GLY A 1 534 ? 155.225 157.490 146.678 1.00 62.05  ? 455 GLY A N   1 
ATOM 3063 C CA  . GLY A 1 534 ? 154.210 157.177 147.671 1.00 53.07  ? 455 GLY A CA  1 
ATOM 3064 C C   . GLY A 1 534 ? 152.944 158.001 147.520 1.00 50.04  ? 455 GLY A C   1 
ATOM 3065 O O   . GLY A 1 534 ? 151.836 157.465 147.591 1.00 48.44  ? 455 GLY A O   1 
ATOM 3066 N N   . THR A 1 535 ? 153.088 159.315 147.306 1.00 51.19  ? 456 THR A N   1 
ATOM 3067 C CA  . THR A 1 535 ? 151.916 160.187 147.359 1.00 48.48  ? 456 THR A CA  1 
ATOM 3068 C C   . THR A 1 535 ? 151.008 160.007 146.148 1.00 48.50  ? 456 THR A C   1 
ATOM 3069 O O   . THR A 1 535 ? 149.784 160.114 146.278 1.00 47.45  ? 456 THR A O   1 
ATOM 3070 C CB  . THR A 1 535 ? 152.324 161.658 147.497 1.00 49.99  ? 456 THR A CB  1 
ATOM 3071 O OG1 . THR A 1 535 ? 151.181 162.489 147.267 1.00 53.89  ? 456 THR A OG1 1 
ATOM 3072 C CG2 . THR A 1 535 ? 153.393 162.034 146.493 1.00 52.46  ? 456 THR A CG2 1 
ATOM 3073 N N   . VAL A 1 536 ? 151.572 159.727 144.972 1.00 47.49  ? 457 VAL A N   1 
ATOM 3074 C CA  . VAL A 1 536 ? 150.722 159.483 143.813 1.00 44.75  ? 457 VAL A CA  1 
ATOM 3075 C C   . VAL A 1 536 ? 150.122 158.081 143.896 1.00 42.23  ? 457 VAL A C   1 
ATOM 3076 O O   . VAL A 1 536 ? 149.043 157.827 143.348 1.00 43.66  ? 457 VAL A O   1 
ATOM 3077 C CB  . VAL A 1 536 ? 151.520 159.714 142.512 1.00 46.91  ? 457 VAL A CB  1 
ATOM 3078 C CG1 . VAL A 1 536 ? 152.741 158.818 142.452 1.00 51.37  ? 457 VAL A CG1 1 
ATOM 3079 C CG2 . VAL A 1 536 ? 150.646 159.581 141.263 1.00 46.64  ? 457 VAL A CG2 1 
ATOM 3080 N N   . ASN A 1 537 ? 150.774 157.167 144.622 1.00 40.98  ? 458 ASN A N   1 
ATOM 3081 C CA  . ASN A 1 537 ? 150.238 155.823 144.813 1.00 42.14  ? 458 ASN A CA  1 
ATOM 3082 C C   . ASN A 1 537 ? 148.946 155.818 145.622 1.00 44.94  ? 458 ASN A C   1 
ATOM 3083 O O   . ASN A 1 537 ? 148.176 154.858 145.528 1.00 48.12  ? 458 ASN A O   1 
ATOM 3084 C CB  . ASN A 1 537 ? 151.282 154.936 145.497 1.00 42.11  ? 458 ASN A CB  1 
ATOM 3085 C CG  . ASN A 1 537 ? 150.914 153.468 145.466 1.00 45.09  ? 458 ASN A CG  1 
ATOM 3086 O OD1 . ASN A 1 537 ? 150.263 153.002 144.534 1.00 46.72  ? 458 ASN A OD1 1 
ATOM 3087 N ND2 . ASN A 1 537 ? 151.331 152.730 146.487 1.00 43.71  ? 458 ASN A ND2 1 
ATOM 3088 N N   . TRP A 1 538 ? 148.687 156.862 146.409 1.00 42.04  ? 459 TRP A N   1 
ATOM 3089 C CA  . TRP A 1 538 ? 147.445 156.972 147.160 1.00 37.95  ? 459 TRP A CA  1 
ATOM 3090 C C   . TRP A 1 538 ? 146.473 157.996 146.596 1.00 38.18  ? 459 TRP A C   1 
ATOM 3091 O O   . TRP A 1 538 ? 145.263 157.796 146.707 1.00 38.05  ? 459 TRP A O   1 
ATOM 3092 C CB  . TRP A 1 538 ? 147.733 157.316 148.626 1.00 37.28  ? 459 TRP A CB  1 
ATOM 3093 C CG  . TRP A 1 538 ? 148.554 156.283 149.334 1.00 38.96  ? 459 TRP A CG  1 
ATOM 3094 C CD1 . TRP A 1 538 ? 149.872 156.369 149.661 1.00 41.00  ? 459 TRP A CD1 1 
ATOM 3095 C CD2 . TRP A 1 538 ? 148.109 155.002 149.794 1.00 40.84  ? 459 TRP A CD2 1 
ATOM 3096 N NE1 . TRP A 1 538 ? 150.279 155.225 150.300 1.00 40.44  ? 459 TRP A NE1 1 
ATOM 3097 C CE2 . TRP A 1 538 ? 149.214 154.369 150.395 1.00 41.72  ? 459 TRP A CE2 1 
ATOM 3098 C CE3 . TRP A 1 538 ? 146.884 154.331 149.760 1.00 41.67  ? 459 TRP A CE3 1 
ATOM 3099 C CZ2 . TRP A 1 538 ? 149.131 153.098 150.955 1.00 46.35  ? 459 TRP A CZ2 1 
ATOM 3100 C CZ3 . TRP A 1 538 ? 146.804 153.070 150.316 1.00 43.34  ? 459 TRP A CZ3 1 
ATOM 3101 C CH2 . TRP A 1 538 ? 147.920 152.467 150.907 1.00 47.12  ? 459 TRP A CH2 1 
ATOM 3102 N N   . LEU A 1 539 ? 146.966 159.091 146.010 1.00 38.87  ? 460 LEU A N   1 
ATOM 3103 C CA  . LEU A 1 539 ? 146.069 160.053 145.375 1.00 39.98  ? 460 LEU A CA  1 
ATOM 3104 C C   . LEU A 1 539 ? 145.400 159.462 144.140 1.00 41.62  ? 460 LEU A C   1 
ATOM 3105 O O   . LEU A 1 539 ? 144.212 159.701 143.899 1.00 45.32  ? 460 LEU A O   1 
ATOM 3106 C CB  . LEU A 1 539 ? 146.823 161.330 145.013 1.00 41.18  ? 460 LEU A CB  1 
ATOM 3107 C CG  . LEU A 1 539 ? 147.255 162.217 146.179 1.00 43.56  ? 460 LEU A CG  1 
ATOM 3108 C CD1 . LEU A 1 539 ? 148.322 163.200 145.733 1.00 46.13  ? 460 LEU A CD1 1 
ATOM 3109 C CD2 . LEU A 1 539 ? 146.051 162.948 146.747 1.00 44.71  ? 460 LEU A CD2 1 
ATOM 3110 N N   . SER A 1 540 ? 146.149 158.701 143.338 1.00 39.06  ? 461 SER A N   1 
ATOM 3111 C CA  . SER A 1 540 ? 145.543 158.026 142.195 1.00 36.19  ? 461 SER A CA  1 
ATOM 3112 C C   . SER A 1 540 ? 144.629 156.896 142.647 1.00 39.26  ? 461 SER A C   1 
ATOM 3113 O O   . SER A 1 540 ? 143.586 156.658 142.032 1.00 39.87  ? 461 SER A O   1 
ATOM 3114 C CB  . SER A 1 540 ? 146.625 157.497 141.257 1.00 39.53  ? 461 SER A CB  1 
ATOM 3115 O OG  . SER A 1 540 ? 147.540 156.676 141.959 1.00 41.94  ? 461 SER A OG  1 
ATOM 3116 N N   . ASN A 1 541 ? 145.012 156.187 143.715 1.00 40.53  ? 462 ASN A N   1 
ATOM 3117 C CA  . ASN A 1 541 ? 144.168 155.132 144.274 1.00 41.57  ? 462 ASN A CA  1 
ATOM 3118 C C   . ASN A 1 541 ? 142.852 155.724 144.773 1.00 41.74  ? 462 ASN A C   1 
ATOM 3119 O O   . ASN A 1 541 ? 141.779 155.144 144.565 1.00 38.49  ? 462 ASN A O   1 
ATOM 3120 C CB  . ASN A 1 541 ? 144.944 154.427 145.397 1.00 39.50  ? 462 ASN A CB  1 
ATOM 3121 C CG  . ASN A 1 541 ? 144.225 153.210 146.005 1.00 38.03  ? 462 ASN A CG  1 
ATOM 3122 O OD1 . ASN A 1 541 ? 143.011 153.038 145.923 1.00 37.73  ? 462 ASN A OD1 1 
ATOM 3123 N ND2 . ASN A 1 541 ? 145.013 152.359 146.647 1.00 37.57  ? 462 ASN A ND2 1 
ATOM 3124 N N   . PHE A 1 542 ? 142.920 156.892 145.415 1.00 40.97  ? 463 PHE A N   1 
ATOM 3125 C CA  . PHE A 1 542 ? 141.717 157.622 145.806 1.00 35.60  ? 463 PHE A CA  1 
ATOM 3126 C C   . PHE A 1 542 ? 140.902 158.065 144.596 1.00 34.94  ? 463 PHE A C   1 
ATOM 3127 O O   . PHE A 1 542 ? 139.677 158.195 144.690 1.00 35.14  ? 463 PHE A O   1 
ATOM 3128 C CB  . PHE A 1 542 ? 142.124 158.812 146.682 1.00 36.77  ? 463 PHE A CB  1 
ATOM 3129 C CG  . PHE A 1 542 ? 141.022 159.800 146.952 1.00 38.65  ? 463 PHE A CG  1 
ATOM 3130 C CD1 . PHE A 1 542 ? 140.140 159.603 147.999 1.00 37.64  ? 463 PHE A CD1 1 
ATOM 3131 C CD2 . PHE A 1 542 ? 140.919 160.966 146.209 1.00 37.38  ? 463 PHE A CD2 1 
ATOM 3132 C CE1 . PHE A 1 542 ? 139.147 160.523 148.268 1.00 36.55  ? 463 PHE A CE1 1 
ATOM 3133 C CE2 . PHE A 1 542 ? 139.927 161.885 146.471 1.00 38.23  ? 463 PHE A CE2 1 
ATOM 3134 C CZ  . PHE A 1 542 ? 139.043 161.665 147.504 1.00 39.83  ? 463 PHE A CZ  1 
ATOM 3135 N N   . ALA A 1 543 ? 141.556 158.302 143.456 1.00 37.46  ? 464 ALA A N   1 
ATOM 3136 C CA  . ALA A 1 543 ? 140.823 158.714 142.262 1.00 37.74  ? 464 ALA A CA  1 
ATOM 3137 C C   . ALA A 1 543 ? 140.015 157.561 141.677 1.00 38.84  ? 464 ALA A C   1 
ATOM 3138 O O   . ALA A 1 543 ? 138.866 157.755 141.264 1.00 39.54  ? 464 ALA A O   1 
ATOM 3139 C CB  . ALA A 1 543 ? 141.786 159.281 141.221 1.00 40.65  ? 464 ALA A CB  1 
ATOM 3140 N N   . VAL A 1 544 ? 140.593 156.358 141.626 1.00 38.45  ? 465 VAL A N   1 
ATOM 3141 C CA  . VAL A 1 544 ? 139.855 155.206 141.110 1.00 39.28  ? 465 VAL A CA  1 
ATOM 3142 C C   . VAL A 1 544 ? 138.729 154.818 142.060 1.00 40.97  ? 465 VAL A C   1 
ATOM 3143 O O   . VAL A 1 544 ? 137.666 154.361 141.626 1.00 38.63  ? 465 VAL A O   1 
ATOM 3144 C CB  . VAL A 1 544 ? 140.800 154.020 140.845 1.00 34.09  ? 465 VAL A CB  1 
ATOM 3145 C CG1 . VAL A 1 544 ? 140.154 153.054 139.890 1.00 29.59  ? 465 VAL A CG1 1 
ATOM 3146 C CG2 . VAL A 1 544 ? 142.090 154.497 140.245 1.00 39.04  ? 465 VAL A CG2 1 
ATOM 3147 N N   . GLY A 1 545 ? 138.947 154.974 143.367 1.00 38.69  ? 466 GLY A N   1 
ATOM 3148 C CA  . GLY A 1 545 ? 137.929 154.591 144.332 1.00 32.84  ? 466 GLY A CA  1 
ATOM 3149 C C   . GLY A 1 545 ? 136.681 155.452 144.266 1.00 34.90  ? 466 GLY A C   1 
ATOM 3150 O O   . GLY A 1 545 ? 135.561 154.941 144.344 1.00 37.86  ? 466 GLY A O   1 
ATOM 3151 N N   . LEU A 1 546 ? 136.852 156.767 144.116 1.00 34.30  ? 467 LEU A N   1 
ATOM 3152 C CA  . LEU A 1 546 ? 135.700 157.662 144.147 1.00 34.85  ? 467 LEU A CA  1 
ATOM 3153 C C   . LEU A 1 546 ? 135.023 157.755 142.784 1.00 39.84  ? 467 LEU A C   1 
ATOM 3154 O O   . LEU A 1 546 ? 133.790 157.767 142.705 1.00 44.25  ? 467 LEU A O   1 
ATOM 3155 C CB  . LEU A 1 546 ? 136.133 159.048 144.647 1.00 32.85  ? 467 LEU A CB  1 
ATOM 3156 C CG  . LEU A 1 546 ? 135.162 160.141 145.137 1.00 37.36  ? 467 LEU A CG  1 
ATOM 3157 C CD1 . LEU A 1 546 ? 135.962 161.242 145.797 1.00 34.45  ? 467 LEU A CD1 1 
ATOM 3158 C CD2 . LEU A 1 546 ? 134.268 160.770 144.069 1.00 38.92  ? 467 LEU A CD2 1 
ATOM 3159 N N   . LEU A 1 547 ? 135.799 157.829 141.705 1.00 38.74  ? 468 LEU A N   1 
ATOM 3160 C CA  . LEU A 1 547 ? 135.234 158.164 140.405 1.00 38.41  ? 468 LEU A CA  1 
ATOM 3161 C C   . LEU A 1 547 ? 134.641 156.976 139.658 1.00 41.25  ? 468 LEU A C   1 
ATOM 3162 O O   . LEU A 1 547 ? 133.794 157.189 138.785 1.00 44.47  ? 468 LEU A O   1 
ATOM 3163 C CB  . LEU A 1 547 ? 136.291 158.836 139.524 1.00 38.72  ? 468 LEU A CB  1 
ATOM 3164 C CG  . LEU A 1 547 ? 136.790 160.200 140.007 1.00 40.25  ? 468 LEU A CG  1 
ATOM 3165 C CD1 . LEU A 1 547 ? 138.210 160.470 139.534 1.00 38.02  ? 468 LEU A CD1 1 
ATOM 3166 C CD2 . LEU A 1 547 ? 135.852 161.304 139.550 1.00 39.36  ? 468 LEU A CD2 1 
ATOM 3167 N N   . PHE A 1 548 ? 135.060 155.748 139.970 1.00 38.13  ? 469 PHE A N   1 
ATOM 3168 C CA  . PHE A 1 548 ? 134.568 154.582 139.234 1.00 36.29  ? 469 PHE A CA  1 
ATOM 3169 C C   . PHE A 1 548 ? 133.055 154.352 139.291 1.00 37.30  ? 469 PHE A C   1 
ATOM 3170 O O   . PHE A 1 548 ? 132.495 153.968 138.249 1.00 40.26  ? 469 PHE A O   1 
ATOM 3171 C CB  . PHE A 1 548 ? 135.305 153.314 139.686 1.00 33.42  ? 469 PHE A CB  1 
ATOM 3172 C CG  . PHE A 1 548 ? 134.946 152.093 138.884 1.00 34.81  ? 469 PHE A CG  1 
ATOM 3173 C CD1 . PHE A 1 548 ? 135.330 151.983 137.562 1.00 35.73  ? 469 PHE A CD1 1 
ATOM 3174 C CD2 . PHE A 1 548 ? 134.213 151.066 139.445 1.00 36.24  ? 469 PHE A CD2 1 
ATOM 3175 C CE1 . PHE A 1 548 ? 135.002 150.866 136.818 1.00 35.18  ? 469 PHE A CE1 1 
ATOM 3176 C CE2 . PHE A 1 548 ? 133.881 149.945 138.707 1.00 32.49  ? 469 PHE A CE2 1 
ATOM 3177 C CZ  . PHE A 1 548 ? 134.276 149.847 137.392 1.00 32.02  ? 469 PHE A CZ  1 
ATOM 3178 N N   . PRO A 1 549 ? 132.345 154.499 140.426 1.00 35.73  ? 470 PRO A N   1 
ATOM 3179 C CA  . PRO A 1 549 ? 130.876 154.366 140.361 1.00 36.97  ? 470 PRO A CA  1 
ATOM 3180 C C   . PRO A 1 549 ? 130.200 155.391 139.468 1.00 41.40  ? 470 PRO A C   1 
ATOM 3181 O O   . PRO A 1 549 ? 129.154 155.090 138.880 1.00 43.68  ? 470 PRO A O   1 
ATOM 3182 C CB  . PRO A 1 549 ? 130.441 154.531 141.822 1.00 38.87  ? 470 PRO A CB  1 
ATOM 3183 C CG  . PRO A 1 549 ? 131.608 154.154 142.605 1.00 37.53  ? 470 PRO A CG  1 
ATOM 3184 C CD  . PRO A 1 549 ? 132.781 154.640 141.831 1.00 37.47  ? 470 PRO A CD  1 
ATOM 3185 N N   . PHE A 1 550 ? 130.757 156.596 139.356 1.00 42.42  ? 471 PHE A N   1 
ATOM 3186 C CA  . PHE A 1 550 ? 130.141 157.617 138.518 1.00 43.84  ? 471 PHE A CA  1 
ATOM 3187 C C   . PHE A 1 550 ? 130.371 157.350 137.035 1.00 44.72  ? 471 PHE A C   1 
ATOM 3188 O O   . PHE A 1 550 ? 129.464 157.553 136.221 1.00 48.29  ? 471 PHE A O   1 
ATOM 3189 C CB  . PHE A 1 550 ? 130.663 158.995 138.915 1.00 44.69  ? 471 PHE A CB  1 
ATOM 3190 C CG  . PHE A 1 550 ? 130.240 159.418 140.289 1.00 48.65  ? 471 PHE A CG  1 
ATOM 3191 C CD1 . PHE A 1 550 ? 128.895 159.529 140.606 1.00 48.94  ? 471 PHE A CD1 1 
ATOM 3192 C CD2 . PHE A 1 550 ? 131.181 159.688 141.269 1.00 48.59  ? 471 PHE A CD2 1 
ATOM 3193 C CE1 . PHE A 1 550 ? 128.496 159.911 141.872 1.00 50.26  ? 471 PHE A CE1 1 
ATOM 3194 C CE2 . PHE A 1 550 ? 130.789 160.071 142.537 1.00 49.51  ? 471 PHE A CE2 1 
ATOM 3195 C CZ  . PHE A 1 550 ? 129.444 160.183 142.839 1.00 51.51  ? 471 PHE A CZ  1 
ATOM 3196 N N   . ILE A 1 551 ? 131.571 156.899 136.658 1.00 42.74  ? 472 ILE A N   1 
ATOM 3197 C CA  . ILE A 1 551 ? 131.809 156.556 135.261 1.00 40.77  ? 472 ILE A CA  1 
ATOM 3198 C C   . ILE A 1 551 ? 131.135 155.244 134.878 1.00 40.75  ? 472 ILE A C   1 
ATOM 3199 O O   . ILE A 1 551 ? 130.963 154.972 133.686 1.00 45.68  ? 472 ILE A O   1 
ATOM 3200 C CB  . ILE A 1 551 ? 133.319 156.524 134.945 1.00 39.58  ? 472 ILE A CB  1 
ATOM 3201 C CG1 . ILE A 1 551 ? 133.943 155.181 135.331 1.00 37.45  ? 472 ILE A CG1 1 
ATOM 3202 C CG2 . ILE A 1 551 ? 134.036 157.699 135.594 1.00 39.50  ? 472 ILE A CG2 1 
ATOM 3203 C CD1 . ILE A 1 551 ? 135.443 155.137 135.151 1.00 36.59  ? 472 ILE A CD1 1 
ATOM 3204 N N   . GLN A 1 552 ? 130.750 154.415 135.852 1.00 40.34  ? 473 GLN A N   1 
ATOM 3205 C CA  . GLN A 1 552 ? 129.905 153.267 135.538 1.00 44.08  ? 473 GLN A CA  1 
ATOM 3206 C C   . GLN A 1 552 ? 128.505 153.711 135.138 1.00 45.94  ? 473 GLN A C   1 
ATOM 3207 O O   . GLN A 1 552 ? 127.874 153.095 134.273 1.00 46.61  ? 473 GLN A O   1 
ATOM 3208 C CB  . GLN A 1 552 ? 129.834 152.311 136.728 1.00 42.86  ? 473 GLN A CB  1 
ATOM 3209 C CG  . GLN A 1 552 ? 130.387 150.925 136.448 1.00 40.18  ? 473 GLN A CG  1 
ATOM 3210 C CD  . GLN A 1 552 ? 130.597 150.115 137.711 1.00 36.23  ? 473 GLN A CD  1 
ATOM 3211 O OE1 . GLN A 1 552 ? 130.644 150.660 138.812 1.00 35.78  ? 473 GLN A OE1 1 
ATOM 3212 N NE2 . GLN A 1 552 ? 130.726 148.803 137.557 1.00 36.12  ? 473 GLN A NE2 1 
ATOM 3213 N N   . LYS A 1 553 ? 128.000 154.773 135.769 1.00 49.01  ? 474 LYS A N   1 
ATOM 3214 C CA  . LYS A 1 553 ? 126.634 155.216 135.514 1.00 51.83  ? 474 LYS A CA  1 
ATOM 3215 C C   . LYS A 1 553 ? 126.503 155.865 134.142 1.00 50.49  ? 474 LYS A C   1 
ATOM 3216 O O   . LYS A 1 553 ? 125.487 155.688 133.460 1.00 53.25  ? 474 LYS A O   1 
ATOM 3217 C CB  . LYS A 1 553 ? 126.193 156.184 136.610 1.00 51.74  ? 474 LYS A CB  1 
ATOM 3218 C CG  . LYS A 1 553 ? 125.893 155.513 137.938 1.00 52.04  ? 474 LYS A CG  1 
ATOM 3219 C CD  . LYS A 1 553 ? 124.651 156.093 138.585 1.00 55.46  ? 474 LYS A CD  1 
ATOM 3220 C CE  . LYS A 1 553 ? 124.757 156.042 140.098 1.00 58.44  ? 474 LYS A CE  1 
ATOM 3221 N NZ  . LYS A 1 553 ? 123.520 156.534 140.763 1.00 66.06  ? 474 LYS A NZ  1 
ATOM 3222 N N   . SER A 1 554 ? 127.516 156.620 133.719 1.00 47.32  ? 475 SER A N   1 
ATOM 3223 C CA  . SER A 1 554 ? 127.445 157.347 132.459 1.00 49.28  ? 475 SER A CA  1 
ATOM 3224 C C   . SER A 1 554 ? 127.845 156.482 131.270 1.00 55.18  ? 475 SER A C   1 
ATOM 3225 O O   . SER A 1 554 ? 127.135 156.441 130.260 1.00 57.95  ? 475 SER A O   1 
ATOM 3226 C CB  . SER A 1 554 ? 128.333 158.593 132.521 1.00 46.36  ? 475 SER A CB  1 
ATOM 3227 O OG  . SER A 1 554 ? 127.888 159.487 133.525 1.00 55.03  ? 475 SER A OG  1 
ATOM 3228 N N   . LEU A 1 555 ? 128.977 155.789 131.371 1.00 56.18  ? 476 LEU A N   1 
ATOM 3229 C CA  . LEU A 1 555 ? 129.501 155.027 130.248 1.00 51.90  ? 476 LEU A CA  1 
ATOM 3230 C C   . LEU A 1 555 ? 128.788 153.689 130.087 1.00 48.74  ? 476 LEU A C   1 
ATOM 3231 O O   . LEU A 1 555 ? 128.861 153.096 129.004 1.00 47.63  ? 476 LEU A O   1 
ATOM 3232 C CB  . LEU A 1 555 ? 131.014 154.871 130.405 1.00 45.46  ? 476 LEU A CB  1 
ATOM 3233 C CG  . LEU A 1 555 ? 131.862 155.947 129.720 1.00 40.48  ? 476 LEU A CG  1 
ATOM 3234 C CD1 . LEU A 1 555 ? 133.329 155.775 130.080 1.00 34.12  ? 476 LEU A CD1 1 
ATOM 3235 C CD2 . LEU A 1 555 ? 131.657 155.990 128.212 1.00 47.87  ? 476 LEU A CD2 1 
ATOM 3236 N N   . ASP A 1 556 ? 128.123 153.213 131.144 1.00 47.86  ? 477 ASP A N   1 
ATOM 3237 C CA  . ASP A 1 556 ? 127.253 152.038 131.156 1.00 53.20  ? 477 ASP A CA  1 
ATOM 3238 C C   . ASP A 1 556 ? 128.008 150.720 130.914 1.00 52.66  ? 477 ASP A C   1 
ATOM 3239 O O   . ASP A 1 556 ? 128.301 150.010 131.881 1.00 50.72  ? 477 ASP A O   1 
ATOM 3240 C CB  . ASP A 1 556 ? 126.077 152.261 130.171 1.00 57.11  ? 477 ASP A CB  1 
ATOM 3241 C CG  . ASP A 1 556 ? 125.455 150.981 129.619 1.00 66.08  ? 477 ASP A CG  1 
ATOM 3242 O OD1 . ASP A 1 556 ? 125.265 150.017 130.393 1.00 68.20  ? 477 ASP A OD1 1 
ATOM 3243 O OD2 . ASP A 1 556 ? 125.161 150.945 128.405 1.00 67.13  ? 477 ASP A OD2 1 
ATOM 3244 N N   . THR A 1 557 ? 128.333 150.367 129.666 1.00 53.42  ? 478 THR A N   1 
ATOM 3245 C CA  . THR A 1 557 ? 129.217 149.244 129.374 1.00 50.50  ? 478 THR A CA  1 
ATOM 3246 C C   . THR A 1 557 ? 130.632 149.733 129.107 1.00 47.48  ? 478 THR A C   1 
ATOM 3247 O O   . THR A 1 557 ? 131.586 148.992 129.365 1.00 43.99  ? 478 THR A O   1 
ATOM 3248 C CB  . THR A 1 557 ? 128.623 148.340 128.286 1.00 48.60  ? 478 THR A CB  1 
ATOM 3249 O OG1 . THR A 1 557 ? 128.880 148.905 126.994 1.00 46.51  ? 478 THR A OG1 1 
ATOM 3250 C CG2 . THR A 1 557 ? 127.135 148.160 128.476 1.00 51.14  ? 478 THR A CG2 1 
ATOM 3251 N N   . TYR A 1 558 ? 130.790 150.950 128.597 1.00 45.87  ? 479 TYR A N   1 
ATOM 3252 C CA  . TYR A 1 558 ? 132.064 151.451 128.107 1.00 41.77  ? 479 TYR A CA  1 
ATOM 3253 C C   . TYR A 1 558 ? 132.936 152.004 129.223 1.00 41.35  ? 479 TYR A C   1 
ATOM 3254 O O   . TYR A 1 558 ? 133.909 152.709 128.939 1.00 43.91  ? 479 TYR A O   1 
ATOM 3255 C CB  . TYR A 1 558 ? 131.840 152.533 127.047 1.00 41.37  ? 479 TYR A CB  1 
ATOM 3256 C CG  . TYR A 1 558 ? 130.978 152.109 125.879 1.00 43.02  ? 479 TYR A CG  1 
ATOM 3257 C CD1 . TYR A 1 558 ? 129.597 152.261 125.920 1.00 42.26  ? 479 TYR A CD1 1 
ATOM 3258 C CD2 . TYR A 1 558 ? 131.542 151.560 124.736 1.00 41.83  ? 479 TYR A CD2 1 
ATOM 3259 C CE1 . TYR A 1 558 ? 128.803 151.876 124.859 1.00 38.77  ? 479 TYR A CE1 1 
ATOM 3260 C CE2 . TYR A 1 558 ? 130.754 151.172 123.668 1.00 40.83  ? 479 TYR A CE2 1 
ATOM 3261 C CZ  . TYR A 1 558 ? 129.386 151.333 123.737 1.00 37.40  ? 479 TYR A CZ  1 
ATOM 3262 O OH  . TYR A 1 558 ? 128.595 150.949 122.680 1.00 40.19  ? 479 TYR A OH  1 
ATOM 3263 N N   . CYS A 1 559 ? 132.607 151.701 130.483 1.00 41.60  ? 480 CYS A N   1 
ATOM 3264 C CA  . CYS A 1 559 ? 133.347 152.239 131.620 1.00 43.94  ? 480 CYS A CA  1 
ATOM 3265 C C   . CYS A 1 559 ? 134.779 151.727 131.687 1.00 41.04  ? 480 CYS A C   1 
ATOM 3266 O O   . CYS A 1 559 ? 135.612 152.339 132.364 1.00 39.78  ? 480 CYS A O   1 
ATOM 3267 C CB  . CYS A 1 559 ? 132.618 151.906 132.922 1.00 44.99  ? 480 CYS A CB  1 
ATOM 3268 S SG  . CYS A 1 559 ? 132.628 150.154 133.354 1.00 51.38  ? 480 CYS A SG  1 
ATOM 3269 N N   . PHE A 1 560 ? 135.085 150.625 131.011 1.00 41.24  ? 481 PHE A N   1 
ATOM 3270 C CA  . PHE A 1 560 ? 136.441 150.105 130.978 1.00 38.85  ? 481 PHE A CA  1 
ATOM 3271 C C   . PHE A 1 560 ? 137.256 150.674 129.826 1.00 37.31  ? 481 PHE A C   1 
ATOM 3272 O O   . PHE A 1 560 ? 138.461 150.412 129.750 1.00 37.74  ? 481 PHE A O   1 
ATOM 3273 C CB  . PHE A 1 560 ? 136.409 148.577 130.895 1.00 35.77  ? 481 PHE A CB  1 
ATOM 3274 C CG  . PHE A 1 560 ? 135.968 147.921 132.170 1.00 36.67  ? 481 PHE A CG  1 
ATOM 3275 C CD1 . PHE A 1 560 ? 136.824 147.832 133.253 1.00 34.41  ? 481 PHE A CD1 1 
ATOM 3276 C CD2 . PHE A 1 560 ? 134.689 147.406 132.291 1.00 37.35  ? 481 PHE A CD2 1 
ATOM 3277 C CE1 . PHE A 1 560 ? 136.420 147.237 134.428 1.00 31.00  ? 481 PHE A CE1 1 
ATOM 3278 C CE2 . PHE A 1 560 ? 134.276 146.809 133.464 1.00 32.34  ? 481 PHE A CE2 1 
ATOM 3279 C CZ  . PHE A 1 560 ? 135.144 146.724 134.533 1.00 30.69  ? 481 PHE A CZ  1 
ATOM 3280 N N   . LEU A 1 561 ? 136.629 151.445 128.934 1.00 38.35  ? 482 LEU A N   1 
ATOM 3281 C CA  . LEU A 1 561 ? 137.367 152.088 127.854 1.00 36.09  ? 482 LEU A CA  1 
ATOM 3282 C C   . LEU A 1 561 ? 138.245 153.219 128.371 1.00 37.60  ? 482 LEU A C   1 
ATOM 3283 O O   . LEU A 1 561 ? 139.280 153.521 127.765 1.00 39.46  ? 482 LEU A O   1 
ATOM 3284 C CB  . LEU A 1 561 ? 136.401 152.610 126.792 1.00 34.51  ? 482 LEU A CB  1 
ATOM 3285 C CG  . LEU A 1 561 ? 136.115 151.693 125.602 1.00 37.80  ? 482 LEU A CG  1 
ATOM 3286 C CD1 . LEU A 1 561 ? 135.515 152.491 124.460 1.00 44.54  ? 482 LEU A CD1 1 
ATOM 3287 C CD2 . LEU A 1 561 ? 137.376 150.971 125.145 1.00 39.35  ? 482 LEU A CD2 1 
ATOM 3288 N N   . VAL A 1 562 ? 137.837 153.871 129.462 1.00 36.56  ? 483 VAL A N   1 
ATOM 3289 C CA  . VAL A 1 562 ? 138.707 154.843 130.120 1.00 35.52  ? 483 VAL A CA  1 
ATOM 3290 C C   . VAL A 1 562 ? 139.952 154.149 130.655 1.00 38.10  ? 483 VAL A C   1 
ATOM 3291 O O   . VAL A 1 562 ? 141.081 154.599 130.433 1.00 38.22  ? 483 VAL A O   1 
ATOM 3292 C CB  . VAL A 1 562 ? 137.945 155.579 131.237 1.00 32.64  ? 483 VAL A CB  1 
ATOM 3293 C CG1 . VAL A 1 562 ? 138.908 156.339 132.134 1.00 32.42  ? 483 VAL A CG1 1 
ATOM 3294 C CG2 . VAL A 1 562 ? 136.922 156.523 130.640 1.00 35.80  ? 483 VAL A CG2 1 
ATOM 3295 N N   . PHE A 1 563 ? 139.763 153.016 131.336 1.00 40.25  ? 484 PHE A N   1 
ATOM 3296 C CA  . PHE A 1 563 ? 140.895 152.233 131.813 1.00 38.91  ? 484 PHE A CA  1 
ATOM 3297 C C   . PHE A 1 563 ? 141.663 151.581 130.675 1.00 36.56  ? 484 PHE A C   1 
ATOM 3298 O O   . PHE A 1 563 ? 142.844 151.271 130.845 1.00 36.98  ? 484 PHE A O   1 
ATOM 3299 C CB  . PHE A 1 563 ? 140.424 151.166 132.798 1.00 34.46  ? 484 PHE A CB  1 
ATOM 3300 C CG  . PHE A 1 563 ? 139.749 151.728 134.005 1.00 35.33  ? 484 PHE A CG  1 
ATOM 3301 C CD1 . PHE A 1 563 ? 140.491 152.168 135.084 1.00 35.59  ? 484 PHE A CD1 1 
ATOM 3302 C CD2 . PHE A 1 563 ? 138.372 151.828 134.057 1.00 37.96  ? 484 PHE A CD2 1 
ATOM 3303 C CE1 . PHE A 1 563 ? 139.871 152.693 136.198 1.00 34.30  ? 484 PHE A CE1 1 
ATOM 3304 C CE2 . PHE A 1 563 ? 137.749 152.351 135.163 1.00 41.03  ? 484 PHE A CE2 1 
ATOM 3305 C CZ  . PHE A 1 563 ? 138.499 152.784 136.238 1.00 38.01  ? 484 PHE A CZ  1 
ATOM 3306 N N   . ALA A 1 564 ? 141.017 151.354 129.530 1.00 33.13  ? 485 ALA A N   1 
ATOM 3307 C CA  . ALA A 1 564 ? 141.754 150.929 128.347 1.00 32.83  ? 485 ALA A CA  1 
ATOM 3308 C C   . ALA A 1 564 ? 142.728 152.009 127.899 1.00 36.48  ? 485 ALA A C   1 
ATOM 3309 O O   . ALA A 1 564 ? 143.866 151.710 127.526 1.00 40.09  ? 485 ALA A O   1 
ATOM 3310 C CB  . ALA A 1 564 ? 140.786 150.578 127.219 1.00 35.11  ? 485 ALA A CB  1 
ATOM 3311 N N   . THR A 1 565 ? 142.304 153.274 127.954 1.00 37.47  ? 486 THR A N   1 
ATOM 3312 C CA  . THR A 1 565 ? 143.149 154.367 127.485 1.00 36.65  ? 486 THR A CA  1 
ATOM 3313 C C   . THR A 1 565 ? 144.333 154.618 128.412 1.00 35.97  ? 486 THR A C   1 
ATOM 3314 O O   . THR A 1 565 ? 145.402 155.019 127.940 1.00 36.98  ? 486 THR A O   1 
ATOM 3315 C CB  . THR A 1 565 ? 142.321 155.642 127.332 1.00 34.59  ? 486 THR A CB  1 
ATOM 3316 O OG1 . THR A 1 565 ? 141.021 155.310 126.832 1.00 37.62  ? 486 THR A OG1 1 
ATOM 3317 C CG2 . THR A 1 565 ? 142.992 156.598 126.360 1.00 34.06  ? 486 THR A CG2 1 
ATOM 3318 N N   . ILE A 1 566 ? 144.169 154.398 129.719 1.00 34.88  ? 487 ILE A N   1 
ATOM 3319 C CA  . ILE A 1 566 ? 145.257 154.658 130.663 1.00 36.80  ? 487 ILE A CA  1 
ATOM 3320 C C   . ILE A 1 566 ? 146.404 153.674 130.453 1.00 39.97  ? 487 ILE A C   1 
ATOM 3321 O O   . ILE A 1 566 ? 147.573 154.070 130.371 1.00 43.70  ? 487 ILE A O   1 
ATOM 3322 C CB  . ILE A 1 566 ? 144.737 154.627 132.113 1.00 35.36  ? 487 ILE A CB  1 
ATOM 3323 C CG1 . ILE A 1 566 ? 143.943 155.895 132.429 1.00 39.05  ? 487 ILE A CG1 1 
ATOM 3324 C CG2 . ILE A 1 566 ? 145.879 154.475 133.103 1.00 35.37  ? 487 ILE A CG2 1 
ATOM 3325 C CD1 . ILE A 1 566 ? 142.618 155.638 133.099 1.00 35.81  ? 487 ILE A CD1 1 
ATOM 3326 N N   . CYS A 1 567 ? 146.090 152.379 130.350 1.00 38.28  ? 488 CYS A N   1 
ATOM 3327 C CA  . CYS A 1 567 ? 147.144 151.383 130.172 1.00 39.33  ? 488 CYS A CA  1 
ATOM 3328 C C   . CYS A 1 567 ? 147.781 151.470 128.789 1.00 39.17  ? 488 CYS A C   1 
ATOM 3329 O O   . CYS A 1 567 ? 148.984 151.225 128.645 1.00 41.93  ? 488 CYS A O   1 
ATOM 3330 C CB  . CYS A 1 567 ? 146.604 149.978 130.434 1.00 39.76  ? 488 CYS A CB  1 
ATOM 3331 S SG  . CYS A 1 567 ? 145.475 149.841 131.832 1.00 44.59  ? 488 CYS A SG  1 
ATOM 3332 N N   . ILE A 1 568 ? 146.997 151.799 127.759 1.00 36.02  ? 489 ILE A N   1 
ATOM 3333 C CA  . ILE A 1 568 ? 147.574 152.012 126.432 1.00 39.28  ? 489 ILE A CA  1 
ATOM 3334 C C   . ILE A 1 568 ? 148.504 153.221 126.443 1.00 46.24  ? 489 ILE A C   1 
ATOM 3335 O O   . ILE A 1 568 ? 149.624 153.166 125.921 1.00 51.56  ? 489 ILE A O   1 
ATOM 3336 C CB  . ILE A 1 568 ? 146.466 152.144 125.371 1.00 40.40  ? 489 ILE A CB  1 
ATOM 3337 C CG1 . ILE A 1 568 ? 145.795 150.789 125.139 1.00 40.70  ? 489 ILE A CG1 1 
ATOM 3338 C CG2 . ILE A 1 568 ? 147.012 152.698 124.065 1.00 39.13  ? 489 ILE A CG2 1 
ATOM 3339 C CD1 . ILE A 1 568 ? 144.541 150.866 124.305 1.00 38.17  ? 489 ILE A CD1 1 
ATOM 3340 N N   . THR A 1 569 ? 148.068 154.322 127.062 1.00 41.93  ? 490 THR A N   1 
ATOM 3341 C CA  . THR A 1 569 ? 148.951 155.477 127.208 1.00 40.15  ? 490 THR A CA  1 
ATOM 3342 C C   . THR A 1 569 ? 150.108 155.179 128.152 1.00 44.89  ? 490 THR A C   1 
ATOM 3343 O O   . THR A 1 569 ? 151.203 155.724 127.977 1.00 49.55  ? 490 THR A O   1 
ATOM 3344 C CB  . THR A 1 569 ? 148.170 156.692 127.706 1.00 36.76  ? 490 THR A CB  1 
ATOM 3345 O OG1 . THR A 1 569 ? 146.858 156.682 127.133 1.00 38.95  ? 490 THR A OG1 1 
ATOM 3346 C CG2 . THR A 1 569 ? 148.872 157.977 127.304 1.00 39.25  ? 490 THR A CG2 1 
ATOM 3347 N N   . GLY A 1 570 ? 149.885 154.329 129.156 1.00 43.90  ? 491 GLY A N   1 
ATOM 3348 C CA  . GLY A 1 570 ? 150.982 153.907 130.010 1.00 42.11  ? 491 GLY A CA  1 
ATOM 3349 C C   . GLY A 1 570 ? 152.002 153.056 129.276 1.00 46.78  ? 491 GLY A C   1 
ATOM 3350 O O   . GLY A 1 570 ? 153.209 153.225 129.459 1.00 51.66  ? 491 GLY A O   1 
ATOM 3351 N N   . ALA A 1 571 ? 151.532 152.133 128.433 1.00 45.00  ? 492 ALA A N   1 
ATOM 3352 C CA  . ALA A 1 571 ? 152.451 151.291 127.673 1.00 45.43  ? 492 ALA A CA  1 
ATOM 3353 C C   . ALA A 1 571 ? 153.150 152.081 126.573 1.00 49.72  ? 492 ALA A C   1 
ATOM 3354 O O   . ALA A 1 571 ? 154.317 151.818 126.262 1.00 55.94  ? 492 ALA A O   1 
ATOM 3355 C CB  . ALA A 1 571 ? 151.705 150.097 127.081 1.00 44.06  ? 492 ALA A CB  1 
ATOM 3356 N N   . ILE A 1 572 ? 152.448 153.039 125.963 1.00 47.55  ? 493 ILE A N   1 
ATOM 3357 C CA  . ILE A 1 572 ? 153.043 153.844 124.900 1.00 49.34  ? 493 ILE A CA  1 
ATOM 3358 C C   . ILE A 1 572 ? 154.130 154.753 125.462 1.00 53.12  ? 493 ILE A C   1 
ATOM 3359 O O   . ILE A 1 572 ? 155.211 154.886 124.873 1.00 58.95  ? 493 ILE A O   1 
ATOM 3360 C CB  . ILE A 1 572 ? 151.942 154.633 124.161 1.00 50.20  ? 493 ILE A CB  1 
ATOM 3361 C CG1 . ILE A 1 572 ? 151.396 153.811 122.996 1.00 58.16  ? 493 ILE A CG1 1 
ATOM 3362 C CG2 . ILE A 1 572 ? 152.446 155.976 123.642 1.00 51.76  ? 493 ILE A CG2 1 
ATOM 3363 C CD1 . ILE A 1 572 ? 150.159 154.404 122.363 1.00 60.09  ? 493 ILE A CD1 1 
ATOM 3364 N N   . TYR A 1 573 ? 153.869 155.378 126.616 1.00 51.45  ? 494 TYR A N   1 
ATOM 3365 C CA  . TYR A 1 573 ? 154.844 156.280 127.222 1.00 51.99  ? 494 TYR A CA  1 
ATOM 3366 C C   . TYR A 1 573 ? 156.097 155.532 127.658 1.00 57.59  ? 494 TYR A C   1 
ATOM 3367 O O   . TYR A 1 573 ? 157.217 156.011 127.453 1.00 63.03  ? 494 TYR A O   1 
ATOM 3368 C CB  . TYR A 1 573 ? 154.212 157.015 128.406 1.00 49.42  ? 494 TYR A CB  1 
ATOM 3369 C CG  . TYR A 1 573 ? 155.105 158.046 129.065 1.00 57.42  ? 494 TYR A CG  1 
ATOM 3370 C CD1 . TYR A 1 573 ? 155.125 159.359 128.614 1.00 65.46  ? 494 TYR A CD1 1 
ATOM 3371 C CD2 . TYR A 1 573 ? 155.902 157.716 130.157 1.00 59.21  ? 494 TYR A CD2 1 
ATOM 3372 C CE1 . TYR A 1 573 ? 155.932 160.309 129.214 1.00 68.94  ? 494 TYR A CE1 1 
ATOM 3373 C CE2 . TYR A 1 573 ? 156.712 158.658 130.762 1.00 64.80  ? 494 TYR A CE2 1 
ATOM 3374 C CZ  . TYR A 1 573 ? 156.721 159.953 130.286 1.00 68.48  ? 494 TYR A CZ  1 
ATOM 3375 O OH  . TYR A 1 573 ? 157.522 160.897 130.885 1.00 68.42  ? 494 TYR A OH  1 
ATOM 3376 N N   . LEU A 1 574 ? 155.930 154.351 128.254 1.00 54.78  ? 495 LEU A N   1 
ATOM 3377 C CA  . LEU A 1 574 ? 157.089 153.599 128.715 1.00 54.42  ? 495 LEU A CA  1 
ATOM 3378 C C   . LEU A 1 574 ? 157.833 152.923 127.573 1.00 59.16  ? 495 LEU A C   1 
ATOM 3379 O O   . LEU A 1 574 ? 158.967 152.477 127.772 1.00 65.75  ? 495 LEU A O   1 
ATOM 3380 C CB  . LEU A 1 574 ? 156.671 152.561 129.755 1.00 47.93  ? 495 LEU A CB  1 
ATOM 3381 C CG  . LEU A 1 574 ? 156.402 153.157 131.136 1.00 45.15  ? 495 LEU A CG  1 
ATOM 3382 C CD1 . LEU A 1 574 ? 155.282 152.419 131.846 1.00 46.01  ? 495 LEU A CD1 1 
ATOM 3383 C CD2 . LEU A 1 574 ? 157.663 153.178 131.969 1.00 50.48  ? 495 LEU A CD2 1 
ATOM 3384 N N   . TYR A 1 575 ? 157.221 152.821 126.392 1.00 57.77  ? 496 TYR A N   1 
ATOM 3385 C CA  . TYR A 1 575 ? 157.944 152.314 125.231 1.00 62.01  ? 496 TYR A CA  1 
ATOM 3386 C C   . TYR A 1 575 ? 159.057 153.267 124.815 1.00 65.73  ? 496 TYR A C   1 
ATOM 3387 O O   . TYR A 1 575 ? 160.158 152.831 124.458 1.00 67.52  ? 496 TYR A O   1 
ATOM 3388 C CB  . TYR A 1 575 ? 156.980 152.082 124.069 1.00 59.83  ? 496 TYR A CB  1 
ATOM 3389 C CG  . TYR A 1 575 ? 157.577 151.275 122.941 1.00 63.22  ? 496 TYR A CG  1 
ATOM 3390 C CD1 . TYR A 1 575 ? 158.187 150.053 123.185 1.00 63.75  ? 496 TYR A CD1 1 
ATOM 3391 C CD2 . TYR A 1 575 ? 157.537 151.739 121.632 1.00 68.70  ? 496 TYR A CD2 1 
ATOM 3392 C CE1 . TYR A 1 575 ? 158.738 149.311 122.157 1.00 73.20  ? 496 TYR A CE1 1 
ATOM 3393 C CE2 . TYR A 1 575 ? 158.085 151.006 120.597 1.00 71.83  ? 496 TYR A CE2 1 
ATOM 3394 C CZ  . TYR A 1 575 ? 158.684 149.792 120.865 1.00 76.18  ? 496 TYR A CZ  1 
ATOM 3395 O OH  . TYR A 1 575 ? 159.231 149.058 119.837 1.00 77.89  ? 496 TYR A OH  1 
ATOM 3396 N N   . PHE A 1 576 ? 158.792 154.571 124.863 1.00 61.43  ? 497 PHE A N   1 
ATOM 3397 C CA  . PHE A 1 576 ? 159.734 155.562 124.362 1.00 63.25  ? 497 PHE A CA  1 
ATOM 3398 C C   . PHE A 1 576 ? 160.690 156.080 125.428 1.00 71.07  ? 497 PHE A C   1 
ATOM 3399 O O   . PHE A 1 576 ? 161.816 156.469 125.098 1.00 77.54  ? 497 PHE A O   1 
ATOM 3400 C CB  . PHE A 1 576 ? 158.971 156.741 123.754 1.00 62.24  ? 497 PHE A CB  1 
ATOM 3401 C CG  . PHE A 1 576 ? 158.353 156.437 122.422 1.00 63.96  ? 497 PHE A CG  1 
ATOM 3402 C CD1 . PHE A 1 576 ? 159.064 155.743 121.457 1.00 67.19  ? 497 PHE A CD1 1 
ATOM 3403 C CD2 . PHE A 1 576 ? 157.059 156.840 122.136 1.00 61.73  ? 497 PHE A CD2 1 
ATOM 3404 C CE1 . PHE A 1 576 ? 158.496 155.459 120.229 1.00 68.39  ? 497 PHE A CE1 1 
ATOM 3405 C CE2 . PHE A 1 576 ? 156.486 156.560 120.910 1.00 60.17  ? 497 PHE A CE2 1 
ATOM 3406 C CZ  . PHE A 1 576 ? 157.205 155.868 119.955 1.00 64.50  ? 497 PHE A CZ  1 
ATOM 3407 N N   . VAL A 1 577 ? 160.279 156.092 126.691 1.00 68.67  ? 498 VAL A N   1 
ATOM 3408 C CA  . VAL A 1 577 ? 161.047 156.724 127.759 1.00 68.17  ? 498 VAL A CA  1 
ATOM 3409 C C   . VAL A 1 577 ? 161.867 155.710 128.547 1.00 68.74  ? 498 VAL A C   1 
ATOM 3410 O O   . VAL A 1 577 ? 163.050 155.930 128.807 1.00 71.39  ? 498 VAL A O   1 
ATOM 3411 C CB  . VAL A 1 577 ? 160.107 157.527 128.684 1.00 65.43  ? 498 VAL A CB  1 
ATOM 3412 C CG1 . VAL A 1 577 ? 160.896 158.212 129.785 1.00 67.28  ? 498 VAL A CG1 1 
ATOM 3413 C CG2 . VAL A 1 577 ? 159.329 158.549 127.875 1.00 69.63  ? 498 VAL A CG2 1 
ATOM 3414 N N   . LEU A 1 578 ? 161.257 154.594 128.929 1.00 62.26  ? 499 LEU A N   1 
ATOM 3415 C CA  . LEU A 1 578 ? 161.919 153.637 129.811 1.00 59.77  ? 499 LEU A CA  1 
ATOM 3416 C C   . LEU A 1 578 ? 163.025 152.888 129.077 1.00 63.50  ? 499 LEU A C   1 
ATOM 3417 O O   . LEU A 1 578 ? 162.777 152.314 128.011 1.00 63.21  ? 499 LEU A O   1 
ATOM 3418 C CB  . LEU A 1 578 ? 160.909 152.641 130.367 1.00 56.63  ? 499 LEU A CB  1 
ATOM 3419 C CG  . LEU A 1 578 ? 161.454 151.571 131.313 1.00 57.59  ? 499 LEU A CG  1 
ATOM 3420 C CD1 . LEU A 1 578 ? 161.993 152.206 132.573 1.00 60.78  ? 499 LEU A CD1 1 
ATOM 3421 C CD2 . LEU A 1 578 ? 160.390 150.538 131.642 1.00 56.27  ? 499 LEU A CD2 1 
ATOM 3422 N N   . PRO A 1 579 ? 164.246 152.877 129.599 1.00 66.01  ? 500 PRO A N   1 
ATOM 3423 C CA  . PRO A 1 579 ? 165.286 151.993 129.074 1.00 70.68  ? 500 PRO A CA  1 
ATOM 3424 C C   . PRO A 1 579 ? 165.290 150.664 129.821 1.00 74.15  ? 500 PRO A C   1 
ATOM 3425 O O   . PRO A 1 579 ? 164.597 150.481 130.823 1.00 75.38  ? 500 PRO A O   1 
ATOM 3426 C CB  . PRO A 1 579 ? 166.568 152.778 129.358 1.00 68.53  ? 500 PRO A CB  1 
ATOM 3427 C CG  . PRO A 1 579 ? 166.259 153.471 130.640 1.00 67.00  ? 500 PRO A CG  1 
ATOM 3428 C CD  . PRO A 1 579 ? 164.787 153.818 130.594 1.00 65.56  ? 500 PRO A CD  1 
ATOM 3429 N N   . GLU A 1 580 ? 166.092 149.735 129.308 1.00 74.75  ? 501 GLU A N   1 
ATOM 3430 C CA  . GLU A 1 580 ? 166.263 148.452 129.976 1.00 76.10  ? 501 GLU A CA  1 
ATOM 3431 C C   . GLU A 1 580 ? 166.999 148.648 131.296 1.00 77.07  ? 501 GLU A C   1 
ATOM 3432 O O   . GLU A 1 580 ? 168.035 149.319 131.347 1.00 79.83  ? 501 GLU A O   1 
ATOM 3433 C CB  . GLU A 1 580 ? 167.028 147.484 129.076 1.00 76.89  ? 501 GLU A CB  1 
ATOM 3434 C CG  . GLU A 1 580 ? 167.287 146.133 129.714 1.00 82.51  ? 501 GLU A CG  1 
ATOM 3435 C CD  . GLU A 1 580 ? 166.012 145.463 130.180 1.00 81.61  ? 501 GLU A CD  1 
ATOM 3436 O OE1 . GLU A 1 580 ? 165.185 145.090 129.321 1.00 78.13  ? 501 GLU A OE1 1 
ATOM 3437 O OE2 . GLU A 1 580 ? 165.833 145.315 131.406 1.00 80.37  ? 501 GLU A OE2 1 
ATOM 3438 N N   . THR A 1 581 ? 166.462 148.064 132.369 1.00 77.10  ? 502 THR A N   1 
ATOM 3439 C CA  . THR A 1 581 ? 166.994 148.275 133.706 1.00 80.62  ? 502 THR A CA  1 
ATOM 3440 C C   . THR A 1 581 ? 167.568 147.026 134.359 1.00 76.78  ? 502 THR A C   1 
ATOM 3441 O O   . THR A 1 581 ? 168.188 147.144 135.422 1.00 78.78  ? 502 THR A O   1 
ATOM 3442 C CB  . THR A 1 581 ? 165.913 148.861 134.629 1.00 83.27  ? 502 THR A CB  1 
ATOM 3443 O OG1 . THR A 1 581 ? 164.637 148.304 134.291 1.00 85.43  ? 502 THR A OG1 1 
ATOM 3444 C CG2 . THR A 1 581 ? 165.857 150.373 134.494 1.00 76.98  ? 502 THR A CG2 1 
ATOM 3445 N N   . LYS A 1 582 ? 167.379 145.846 133.776 1.00 70.66  ? 503 LYS A N   1 
ATOM 3446 C CA  . LYS A 1 582 ? 168.013 144.646 134.303 1.00 73.04  ? 503 LYS A CA  1 
ATOM 3447 C C   . LYS A 1 582 ? 169.522 144.718 134.088 1.00 80.78  ? 503 LYS A C   1 
ATOM 3448 O O   . LYS A 1 582 ? 169.997 145.348 133.140 1.00 83.35  ? 503 LYS A O   1 
ATOM 3449 C CB  . LYS A 1 582 ? 167.430 143.396 133.638 1.00 75.08  ? 503 LYS A CB  1 
ATOM 3450 C CG  . LYS A 1 582 ? 167.769 142.091 134.349 1.00 77.81  ? 503 LYS A CG  1 
ATOM 3451 C CD  . LYS A 1 582 ? 167.023 140.901 133.769 1.00 81.25  ? 503 LYS A CD  1 
ATOM 3452 C CE  . LYS A 1 582 ? 165.805 140.560 134.609 1.00 83.03  ? 503 LYS A CE  1 
ATOM 3453 N NZ  . LYS A 1 582 ? 165.088 139.355 134.113 1.00 84.39  ? 503 LYS A NZ  1 
ATOM 3454 N N   . ASN A 1 583 ? 170.264 144.118 135.033 1.00 82.04  ? 504 ASN A N   1 
ATOM 3455 C CA  . ASN A 1 583 ? 171.723 143.958 135.104 1.00 80.38  ? 504 ASN A CA  1 
ATOM 3456 C C   . ASN A 1 583 ? 172.529 145.168 134.626 1.00 79.94  ? 504 ASN A C   1 
ATOM 3457 O O   . ASN A 1 583 ? 173.564 145.026 133.968 1.00 79.48  ? 504 ASN A O   1 
ATOM 3458 C CB  . ASN A 1 583 ? 172.151 142.639 134.412 1.00 82.07  ? 504 ASN A CB  1 
ATOM 3459 C CG  . ASN A 1 583 ? 171.990 142.618 132.873 1.00 85.65  ? 504 ASN A CG  1 
ATOM 3460 O OD1 . ASN A 1 583 ? 171.865 143.633 132.196 1.00 83.09  ? 504 ASN A OD1 1 
ATOM 3461 N ND2 . ASN A 1 583 ? 171.994 141.408 132.328 1.00 87.85  ? 504 ASN A ND2 1 
ATOM 3462 N N   . ARG A 1 584 ? 172.077 146.361 135.000 1.00 81.91  ? 505 ARG A N   1 
ATOM 3463 C CA  . ARG A 1 584 ? 172.720 147.612 134.633 1.00 83.32  ? 505 ARG A CA  1 
ATOM 3464 C C   . ARG A 1 584 ? 173.046 148.404 135.890 1.00 86.85  ? 505 ARG A C   1 
ATOM 3465 O O   . ARG A 1 584 ? 172.247 148.448 136.832 1.00 85.03  ? 505 ARG A O   1 
ATOM 3466 C CB  . ARG A 1 584 ? 171.821 148.451 133.718 1.00 82.02  ? 505 ARG A CB  1 
ATOM 3467 C CG  . ARG A 1 584 ? 171.779 148.003 132.267 1.00 84.41  ? 505 ARG A CG  1 
ATOM 3468 C CD  . ARG A 1 584 ? 171.523 149.185 131.346 1.00 85.52  ? 505 ARG A CD  1 
ATOM 3469 N NE  . ARG A 1 584 ? 172.311 149.109 130.122 1.00 86.17  ? 505 ARG A NE  1 
ATOM 3470 C CZ  . ARG A 1 584 ? 171.898 148.531 129.003 1.00 84.20  ? 505 ARG A CZ  1 
ATOM 3471 N NH1 . ARG A 1 584 ? 170.705 147.967 128.916 1.00 84.63  ? 505 ARG A NH1 1 
ATOM 3472 N NH2 . ARG A 1 584 ? 172.701 148.524 127.943 1.00 83.31  ? 505 ARG A NH2 1 
ATOM 3473 N N   . THR A 1 585 ? 174.219 149.030 135.901 1.00 89.37  ? 506 THR A N   1 
ATOM 3474 C CA  . THR A 1 585 ? 174.582 149.911 136.997 1.00 86.86  ? 506 THR A CA  1 
ATOM 3475 C C   . THR A 1 585 ? 173.824 151.233 136.883 1.00 87.83  ? 506 THR A C   1 
ATOM 3476 O O   . THR A 1 585 ? 173.144 151.509 135.891 1.00 92.37  ? 506 THR A O   1 
ATOM 3477 C CB  . THR A 1 585 ? 176.089 150.163 137.008 1.00 88.75  ? 506 THR A CB  1 
ATOM 3478 O OG1 . THR A 1 585 ? 176.439 151.024 135.917 1.00 85.90  ? 506 THR A OG1 1 
ATOM 3479 C CG2 . THR A 1 585 ? 176.844 148.850 136.876 1.00 86.69  ? 506 THR A CG2 1 
ATOM 3480 N N   . TYR A 1 586 ? 173.945 152.058 137.928 1.00 86.14  ? 507 TYR A N   1 
ATOM 3481 C CA  . TYR A 1 586 ? 173.261 153.348 137.944 1.00 86.45  ? 507 TYR A CA  1 
ATOM 3482 C C   . TYR A 1 586 ? 173.804 154.292 136.876 1.00 87.33  ? 507 TYR A C   1 
ATOM 3483 O O   . TYR A 1 586 ? 173.061 155.142 136.369 1.00 89.92  ? 507 TYR A O   1 
ATOM 3484 C CB  . TYR A 1 586 ? 173.373 153.979 139.336 1.00 85.14  ? 507 TYR A CB  1 
ATOM 3485 C CG  . TYR A 1 586 ? 173.143 155.474 139.370 1.00 87.74  ? 507 TYR A CG  1 
ATOM 3486 C CD1 . TYR A 1 586 ? 171.867 156.003 139.230 1.00 83.16  ? 507 TYR A CD1 1 
ATOM 3487 C CD2 . TYR A 1 586 ? 174.202 156.357 139.543 1.00 92.08  ? 507 TYR A CD2 1 
ATOM 3488 C CE1 . TYR A 1 586 ? 171.652 157.367 139.256 1.00 82.30  ? 507 TYR A CE1 1 
ATOM 3489 C CE2 . TYR A 1 586 ? 173.996 157.723 139.572 1.00 91.17  ? 507 TYR A CE2 1 
ATOM 3490 C CZ  . TYR A 1 586 ? 172.719 158.221 139.428 1.00 89.25  ? 507 TYR A CZ  1 
ATOM 3491 O OH  . TYR A 1 586 ? 172.506 159.579 139.457 1.00 96.23  ? 507 TYR A OH  1 
ATOM 3492 N N   . ALA A 1 587 ? 175.084 154.148 136.517 1.00 84.76  ? 508 ALA A N   1 
ATOM 3493 C CA  . ALA A 1 587 ? 175.694 155.031 135.526 1.00 85.63  ? 508 ALA A CA  1 
ATOM 3494 C C   . ALA A 1 587 ? 175.042 154.878 134.156 1.00 89.31  ? 508 ALA A C   1 
ATOM 3495 O O   . ALA A 1 587 ? 174.788 155.874 133.469 1.00 91.85  ? 508 ALA A O   1 
ATOM 3496 C CB  . ALA A 1 587 ? 177.195 154.758 135.438 1.00 88.49  ? 508 ALA A CB  1 
ATOM 3497 N N   . GLU A 1 588 ? 174.755 153.640 133.745 1.00 89.02  ? 509 GLU A N   1 
ATOM 3498 C CA  . GLU A 1 588 ? 174.117 153.433 132.448 1.00 88.55  ? 509 GLU A CA  1 
ATOM 3499 C C   . GLU A 1 588 ? 172.642 153.810 132.472 1.00 85.82  ? 509 GLU A C   1 
ATOM 3500 O O   . GLU A 1 588 ? 172.101 154.236 131.445 1.00 87.18  ? 509 GLU A O   1 
ATOM 3501 C CB  . GLU A 1 588 ? 174.287 151.983 131.998 1.00 89.43  ? 509 GLU A CB  1 
ATOM 3502 C CG  . GLU A 1 588 ? 175.734 151.548 131.849 1.00 91.76  ? 509 GLU A CG  1 
ATOM 3503 C CD  . GLU A 1 588 ? 175.937 150.606 130.679 1.00 96.00  ? 509 GLU A CD  1 
ATOM 3504 O OE1 . GLU A 1 588 ? 175.329 149.515 130.677 1.00 94.19  ? 509 GLU A OE1 1 
ATOM 3505 O OE2 . GLU A 1 588 ? 176.702 150.960 129.756 1.00 98.63  ? 509 GLU A OE2 1 
ATOM 3506 N N   . ILE A 1 589 ? 171.973 153.645 133.616 1.00 84.27  ? 510 ILE A N   1 
ATOM 3507 C CA  . ILE A 1 589 ? 170.582 154.074 133.736 1.00 85.16  ? 510 ILE A CA  1 
ATOM 3508 C C   . ILE A 1 589 ? 170.482 155.590 133.625 1.00 86.18  ? 510 ILE A C   1 
ATOM 3509 O O   . ILE A 1 589 ? 169.594 156.120 132.946 1.00 85.06  ? 510 ILE A O   1 
ATOM 3510 C CB  . ILE A 1 589 ? 169.971 153.553 135.051 1.00 82.29  ? 510 ILE A CB  1 
ATOM 3511 C CG1 . ILE A 1 589 ? 170.023 152.025 135.102 1.00 85.18  ? 510 ILE A CG1 1 
ATOM 3512 C CG2 . ILE A 1 589 ? 168.537 154.024 135.206 1.00 76.76  ? 510 ILE A CG2 1 
ATOM 3513 C CD1 . ILE A 1 589 ? 169.474 151.346 133.867 1.00 84.56  ? 510 ILE A CD1 1 
ATOM 3514 N N   . SER A 1 590 ? 171.397 156.312 134.277 1.00 89.49  ? 511 SER A N   1 
ATOM 3515 C CA  . SER A 1 590 ? 171.435 157.762 134.129 1.00 92.66  ? 511 SER A CA  1 
ATOM 3516 C C   . SER A 1 590 ? 171.879 158.173 132.731 1.00 93.24  ? 511 SER A C   1 
ATOM 3517 O O   . SER A 1 590 ? 171.447 159.218 132.232 1.00 93.97  ? 511 SER A O   1 
ATOM 3518 C CB  . SER A 1 590 ? 172.360 158.375 135.180 1.00 95.66  ? 511 SER A CB  1 
ATOM 3519 O OG  . SER A 1 590 ? 171.970 159.701 135.489 1.00 101.48 ? 511 SER A OG  1 
ATOM 3520 N N   . GLN A 1 591 ? 172.741 157.371 132.096 1.00 94.26  ? 512 GLN A N   1 
ATOM 3521 C CA  . GLN A 1 591 ? 173.213 157.681 130.749 1.00 93.06  ? 512 GLN A CA  1 
ATOM 3522 C C   . GLN A 1 591 ? 172.075 157.646 129.736 1.00 96.72  ? 512 GLN A C   1 
ATOM 3523 O O   . GLN A 1 591 ? 172.025 158.476 128.821 1.00 99.16  ? 512 GLN A O   1 
ATOM 3524 C CB  . GLN A 1 591 ? 174.312 156.701 130.339 1.00 92.83  ? 512 GLN A CB  1 
ATOM 3525 C CG  . GLN A 1 591 ? 175.186 157.186 129.195 1.00 95.60  ? 512 GLN A CG  1 
ATOM 3526 C CD  . GLN A 1 591 ? 176.194 158.226 129.636 1.00 100.70 ? 512 GLN A CD  1 
ATOM 3527 O OE1 . GLN A 1 591 ? 177.268 157.891 130.138 1.00 104.53 ? 512 GLN A OE1 1 
ATOM 3528 N NE2 . GLN A 1 591 ? 175.854 159.497 129.456 1.00 102.55 ? 512 GLN A NE2 1 
ATOM 3529 N N   . ALA A 1 592 ? 171.165 156.678 129.875 1.00 96.48  ? 513 ALA A N   1 
ATOM 3530 C CA  . ALA A 1 592 ? 170.035 156.575 128.957 1.00 92.63  ? 513 ALA A CA  1 
ATOM 3531 C C   . ALA A 1 592 ? 169.102 157.771 129.087 1.00 92.53  ? 513 ALA A C   1 
ATOM 3532 O O   . ALA A 1 592 ? 168.580 158.273 128.084 1.00 93.51  ? 513 ALA A O   1 
ATOM 3533 C CB  . ALA A 1 592 ? 169.277 155.273 129.204 1.00 83.17  ? 513 ALA A CB  1 
ATOM 3534 N N   . PHE A 1 593 ? 168.875 158.242 130.314 1.00 91.34  ? 514 PHE A N   1 
ATOM 3535 C CA  . PHE A 1 593 ? 168.039 159.423 130.499 1.00 92.53  ? 514 PHE A CA  1 
ATOM 3536 C C   . PHE A 1 593 ? 168.758 160.697 130.075 1.00 98.32  ? 514 PHE A C   1 
ATOM 3537 O O   . PHE A 1 593 ? 168.102 161.673 129.693 1.00 100.75 ? 514 PHE A O   1 
ATOM 3538 C CB  . PHE A 1 593 ? 167.584 159.534 131.953 1.00 90.45  ? 514 PHE A CB  1 
ATOM 3539 C CG  . PHE A 1 593 ? 166.438 158.630 132.301 1.00 87.36  ? 514 PHE A CG  1 
ATOM 3540 C CD1 . PHE A 1 593 ? 166.645 157.280 132.526 1.00 81.76  ? 514 PHE A CD1 1 
ATOM 3541 C CD2 . PHE A 1 593 ? 165.148 159.129 132.386 1.00 83.69  ? 514 PHE A CD2 1 
ATOM 3542 C CE1 . PHE A 1 593 ? 165.593 156.450 132.843 1.00 73.77  ? 514 PHE A CE1 1 
ATOM 3543 C CE2 . PHE A 1 593 ? 164.090 158.300 132.701 1.00 75.30  ? 514 PHE A CE2 1 
ATOM 3544 C CZ  . PHE A 1 593 ? 164.313 156.958 132.929 1.00 70.57  ? 514 PHE A CZ  1 
ATOM 3545 N N   . SER A 1 594 ? 170.095 160.708 130.131 1.00 100.96 ? 515 SER A N   1 
ATOM 3546 C CA  . SER A 1 594 ? 170.862 161.895 129.760 1.00 101.26 ? 515 SER A CA  1 
ATOM 3547 C C   . SER A 1 594 ? 170.740 162.231 128.280 1.00 103.04 ? 515 SER A C   1 
ATOM 3548 O O   . SER A 1 594 ? 171.006 163.375 127.893 1.00 103.61 ? 515 SER A O   1 
ATOM 3549 C CB  . SER A 1 594 ? 172.336 161.713 130.124 1.00 98.37  ? 515 SER A CB  1 
ATOM 3550 O OG  . SER A 1 594 ? 172.483 160.985 131.327 1.00 97.24  ? 515 SER A OG  1 
ATOM 3551 N N   . LYS A 1 595 ? 170.371 161.256 127.446 1.00 102.28 ? 516 LYS A N   1 
ATOM 3552 C CA  . LYS A 1 595 ? 170.077 161.541 126.046 1.00 105.00 ? 516 LYS A CA  1 
ATOM 3553 C C   . LYS A 1 595 ? 168.871 162.469 125.931 1.00 107.56 ? 516 LYS A C   1 
ATOM 3554 O O   . LYS A 1 595 ? 168.869 163.404 125.122 1.00 107.61 ? 516 LYS A O   1 
ATOM 3555 C CB  . LYS A 1 595 ? 169.836 160.224 125.300 1.00 104.57 ? 516 LYS A CB  1 
ATOM 3556 C CG  . LYS A 1 595 ? 169.301 160.317 123.865 1.00 108.08 ? 516 LYS A CG  1 
ATOM 3557 C CD  . LYS A 1 595 ? 170.094 161.283 122.987 1.00 104.80 ? 516 LYS A CD  1 
ATOM 3558 C CE  . LYS A 1 595 ? 169.376 161.543 121.674 1.00 102.18 ? 516 LYS A CE  1 
ATOM 3559 N NZ  . LYS A 1 595 ? 169.526 160.406 120.726 1.00 99.64  ? 516 LYS A NZ  1 
ATOM 3560 N N   . ARG A 1 596 ? 167.848 162.242 126.754 1.00 105.60 ? 517 ARG A N   1 
ATOM 3561 C CA  . ARG A 1 596 ? 166.618 163.020 126.706 1.00 104.00 ? 517 ARG A CA  1 
ATOM 3562 C C   . ARG A 1 596 ? 166.597 164.172 127.704 1.00 106.39 ? 517 ARG A C   1 
ATOM 3563 O O   . ARG A 1 596 ? 165.951 165.193 127.441 1.00 108.24 ? 517 ARG A O   1 
ATOM 3564 C CB  . ARG A 1 596 ? 165.418 162.092 126.951 1.00 96.65  ? 517 ARG A CB  1 
ATOM 3565 C CG  . ARG A 1 596 ? 164.045 162.729 126.799 1.00 93.45  ? 517 ARG A CG  1 
ATOM 3566 C CD  . ARG A 1 596 ? 162.929 161.735 127.087 1.00 90.98  ? 517 ARG A CD  1 
ATOM 3567 N NE  . ARG A 1 596 ? 163.373 160.350 126.992 1.00 86.70  ? 517 ARG A NE  1 
ATOM 3568 C CZ  . ARG A 1 596 ? 163.173 159.570 125.938 1.00 81.47  ? 517 ARG A CZ  1 
ATOM 3569 N NH1 . ARG A 1 596 ? 162.539 160.011 124.864 1.00 80.35  ? 517 ARG A NH1 1 
ATOM 3570 N NH2 . ARG A 1 596 ? 163.620 158.318 125.962 1.00 76.33  ? 517 ARG A NH2 1 
ATOM 3571 N N   . ASN A 1 597 ? 167.312 164.046 128.828 1.00 105.82 ? 518 ASN A N   1 
ATOM 3572 C CA  . ASN A 1 597 ? 167.292 165.088 129.852 1.00 106.60 ? 518 ASN A CA  1 
ATOM 3573 C C   . ASN A 1 597 ? 167.973 166.368 129.387 1.00 112.29 ? 518 ASN A C   1 
ATOM 3574 O O   . ASN A 1 597 ? 167.586 167.460 129.821 1.00 114.45 ? 518 ASN A O   1 
ATOM 3575 C CB  . ASN A 1 597 ? 167.956 164.586 131.134 1.00 104.47 ? 518 ASN A CB  1 
ATOM 3576 C CG  . ASN A 1 597 ? 166.955 164.073 132.146 1.00 100.36 ? 518 ASN A CG  1 
ATOM 3577 O OD1 . ASN A 1 597 ? 166.007 164.770 132.508 1.00 98.12  ? 518 ASN A OD1 1 
ATOM 3578 N ND2 . ASN A 1 597 ? 167.161 162.848 132.612 1.00 97.47  ? 518 ASN A ND2 1 
ATOM 3579 N N   . LYS A 1 598 ? 169.010 166.248 128.545 1.00 115.71 ? 519 LYS A N   1 
ATOM 3580 C CA  . LYS A 1 598 ? 169.824 167.340 127.996 1.00 123.08 ? 519 LYS A CA  1 
ATOM 3581 C C   . LYS A 1 598 ? 170.591 168.126 129.062 1.00 127.76 ? 519 LYS A C   1 
ATOM 3582 O O   . LYS A 1 598 ? 171.276 169.102 128.737 1.00 128.43 ? 519 LYS A O   1 
ATOM 3583 C CB  . LYS A 1 598 ? 168.987 168.311 127.140 1.00 120.60 ? 519 LYS A CB  1 
ATOM 3584 C CG  . LYS A 1 598 ? 167.883 167.683 126.286 1.00 118.81 ? 519 LYS A CG  1 
ATOM 3585 C CD  . LYS A 1 598 ? 166.869 168.729 125.847 1.00 117.39 ? 519 LYS A CD  1 
ATOM 3586 C CE  . LYS A 1 598 ? 165.540 168.092 125.470 1.00 115.92 ? 519 LYS A CE  1 
ATOM 3587 N NZ  . LYS A 1 598 ? 164.688 167.833 126.666 1.00 108.82 ? 519 LYS A NZ  1 
ATOM 3588 N N   . ALA A 1 599 ? 170.488 167.721 130.329 1.00 128.70 ? 520 ALA A N   1 
ATOM 3589 C CA  . ALA A 1 599 ? 171.261 168.318 131.417 1.00 130.40 ? 520 ALA A CA  1 
ATOM 3590 C C   . ALA A 1 599 ? 172.407 167.369 131.754 1.00 133.68 ? 520 ALA A C   1 
ATOM 3591 O O   . ALA A 1 599 ? 172.373 166.628 132.737 1.00 128.86 ? 520 ALA A O   1 
ATOM 3592 C CB  . ALA A 1 599 ? 170.371 168.595 132.624 1.00 119.89 ? 520 ALA A CB  1 
ATOM 3593 N N   . TYR A 1 600 ? 173.428 167.390 130.908 1.00 136.25 ? 521 TYR A N   1 
ATOM 3594 C CA  . TYR A 1 600 ? 174.582 166.520 131.106 1.00 136.85 ? 521 TYR A CA  1 
ATOM 3595 C C   . TYR A 1 600 ? 175.383 166.981 132.319 1.00 140.59 ? 521 TYR A C   1 
ATOM 3596 O O   . TYR A 1 600 ? 175.644 168.182 132.463 1.00 139.59 ? 521 TYR A O   1 
ATOM 3597 C CB  . TYR A 1 600 ? 175.465 166.509 129.859 1.00 135.73 ? 521 TYR A CB  1 
ATOM 3598 C CG  . TYR A 1 600 ? 174.716 166.768 128.570 1.00 135.01 ? 521 TYR A CG  1 
ATOM 3599 C CD1 . TYR A 1 600 ? 173.793 165.848 128.082 1.00 133.23 ? 521 TYR A CD1 1 
ATOM 3600 C CD2 . TYR A 1 600 ? 174.929 167.932 127.843 1.00 134.61 ? 521 TYR A CD2 1 
ATOM 3601 C CE1 . TYR A 1 600 ? 173.105 166.082 126.904 1.00 133.81 ? 521 TYR A CE1 1 
ATOM 3602 C CE2 . TYR A 1 600 ? 174.246 168.175 126.664 1.00 134.08 ? 521 TYR A CE2 1 
ATOM 3603 C CZ  . TYR A 1 600 ? 173.336 167.246 126.200 1.00 134.63 ? 521 TYR A CZ  1 
ATOM 3604 O OH  . TYR A 1 600 ? 172.655 167.484 125.029 1.00 136.14 ? 521 TYR A OH  1 
ATOM 3605 N N   . PRO A 1 601 ? 175.790 166.067 133.214 1.00 141.64 ? 522 PRO A N   1 
ATOM 3606 C CA  . PRO A 1 601 ? 176.517 166.421 134.438 1.00 138.63 ? 522 PRO A CA  1 
ATOM 3607 C C   . PRO A 1 601 ? 177.950 166.869 134.168 1.00 136.62 ? 522 PRO A C   1 
ATOM 3608 O O   . PRO A 1 601 ? 178.698 167.076 135.123 1.00 131.49 ? 522 PRO A O   1 
ATOM 3609 C CB  . PRO A 1 601 ? 176.499 165.120 135.242 1.00 135.01 ? 522 PRO A CB  1 
ATOM 3610 C CG  . PRO A 1 601 ? 176.416 164.051 134.211 1.00 136.42 ? 522 PRO A CG  1 
ATOM 3611 C CD  . PRO A 1 601 ? 175.581 164.612 133.096 1.00 137.09 ? 522 PRO A CD  1 
# 
