data_9C93
# 
_entry.id   9C93 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9C93         pdb_00009c93 10.2210/pdb9c93/pdb 
WWPDB D_1000284873 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-15 ? 
2 'Structure model' 1 1 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.title'                   
6 2 'Structure model' '_citation.year'                    
7 2 'Structure model' '_citation_author.name'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9C93 
_pdbx_database_status.recvd_initial_deposition_date   2024-06-13 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           N 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB . 9C92 unspecified 
PDB . 9C94 unspecified 
# 
_pdbx_contact_author.id                 3 
_pdbx_contact_author.email              tung-chung.mou@pfizer.com 
_pdbx_contact_author.name_first         Tung-Chung 
_pdbx_contact_author.name_last          Mou 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0001-6554-1519 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bester, S.M.' 1 0000-0001-7137-0090 
'Wu, W.-I.'    2 0009-0006-0363-8183 
'Mou, T.-C.'   3 0000-0001-6554-1519 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Acs Med.Chem.Lett.' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1948-5875 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            16 
_citation.language                  ? 
_citation.page_first                224 
_citation.page_last                 233 
_citation.title                     
'Design of Potent Menin-KMT2A Interaction Inhibitors with Improved In Vitro ADME Properties and Reduced hERG Affinity.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1021/acsmedchemlett.4c00311 
_citation.pdbx_database_id_PubMed   39967615 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chapsal, B.D.'         1  ? 
primary 'Kimbrough, J.R.'       2  ? 
primary 'Bester, S.M.'          3  ? 
primary 'Bergstrom, A.'         4  ? 
primary 'Backos, D.S.'          5  ? 
primary 'Campos, B.'            6  ? 
primary 'McDonald, M.G.'        7  ? 
primary 'Abrahamsen, R.'        8  ? 
primary 'Allen, A.C.'           9  ? 
primary 'Doerner Barbour, P.M.' 10 ? 
primary 'Bettendorf, T.'        11 ? 
primary 'Boys, M.L.'            12 ? 
primary 'Brown, K.'             13 ? 
primary 'Chicarelli, M.J.'      14 ? 
primary 'Cook, A.W.'            15 ? 
primary 'Crooks, A.L.'          16 ? 
primary 'Cruz, C.L.'            17 ? 
primary 'Dahlke, J.R.'          18 ? 
primary 'Eide, A.'              19 ? 
primary 'Fell, J.B.'            20 ? 
primary 'Fulton, J.L.'          21 ? 
primary 'Gargus, M.'            22 ? 
primary 'Gaudino, J.J.'         23 ? 
primary 'Guarnieri, A.L.'       24 ? 
primary 'Hansen, E.P.'          25 ? 
primary 'Holt, M.C.'            26 ? 
primary 'Kahn, D.R.'            27 ? 
primary 'Laird, E.R.'           28 ? 
primary 'Larsen, P.D.'          29 ? 
primary 'Linwood, R.'           30 ? 
primary 'Martinson, M.C.'       31 ? 
primary 'McCown, J.'            32 ? 
primary 'Mejia, M.J.'           33 ? 
primary 'Moreno, D.A.'          34 ? 
primary 'Mou, T.C.'             35 ? 
primary 'Newhouse, B.'          36 ? 
primary 
;O'Leary, J.M.
;
37 ? 
primary 'Rodriguez, M.E.'       38 ? 
primary 'Singh, A.'             39 ? 
primary 'Sinik, L.'             40 ? 
primary 'Strand, K.A.'          41 ? 
primary 'Touney, E.E.'          42 ? 
primary 'Wollenberg, L.A.'      43 ? 
primary 'Wong, J.'              44 ? 
primary 'Zhou, Y.'              45 ? 
primary 'Fischer, J.P.'         46 ? 
primary 'Allen, S.'             47 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man Menin 57010.496 2   ? A5T ? ? 
2 non-polymer syn 
;(1R,5R)-2-({5-fluoro-2-[(5-{7-[(1-methylcyclopropyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl}-1,2,4-triazin-6-yl)oxy]phenyl}methyl)-2-azabicyclo[3.1.0]hexan-3-one
;
492.588   2   ? ?   ? ? 
3 non-polymer syn 'POTASSIUM ION' 39.098    2   ? ?   ? ? 
4 non-polymer syn '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' 238.305   1   ? ?   ? ? 
5 non-polymer syn 'SULFATE ION' 96.063    1   ? ?   ? ? 
6 water       nat water 18.015    686 ? ?   ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MHHHHHHSSGRENLYFQGSGLKTAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELT
FQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQS
LFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLY
LKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLY
HKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASL
LEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRITFQSE
KMKGMKELLVATKINSSAIKLQLTAQS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MHHHHHHSSGRENLYFQGSGLKTAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELT
FQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQS
LFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLY
LKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLY
HKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASL
LEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRITFQSE
KMKGMKELLVATKINSSAIKLQLTAQS
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 
;(1R,5R)-2-({5-fluoro-2-[(5-{7-[(1-methylcyclopropyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl}-1,2,4-triazin-6-yl)oxy]phenyl}methyl)-2-azabicyclo[3.1.0]hexan-3-one
;
A1AVF 
3 'POTASSIUM ION' K     
4 '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' EPE   
5 'SULFATE ION' SO4   
6 water HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   HIS n 
1 3   HIS n 
1 4   HIS n 
1 5   HIS n 
1 6   HIS n 
1 7   HIS n 
1 8   SER n 
1 9   SER n 
1 10  GLY n 
1 11  ARG n 
1 12  GLU n 
1 13  ASN n 
1 14  LEU n 
1 15  TYR n 
1 16  PHE n 
1 17  GLN n 
1 18  GLY n 
1 19  SER n 
1 20  GLY n 
1 21  LEU n 
1 22  LYS n 
1 23  THR n 
1 24  ALA n 
1 25  GLN n 
1 26  LYS n 
1 27  THR n 
1 28  LEU n 
1 29  PHE n 
1 30  PRO n 
1 31  LEU n 
1 32  ARG n 
1 33  SER n 
1 34  ILE n 
1 35  ASP n 
1 36  ASP n 
1 37  VAL n 
1 38  VAL n 
1 39  ARG n 
1 40  LEU n 
1 41  PHE n 
1 42  ALA n 
1 43  ALA n 
1 44  GLU n 
1 45  LEU n 
1 46  GLY n 
1 47  ARG n 
1 48  GLU n 
1 49  GLU n 
1 50  PRO n 
1 51  ASP n 
1 52  LEU n 
1 53  VAL n 
1 54  LEU n 
1 55  LEU n 
1 56  SER n 
1 57  LEU n 
1 58  VAL n 
1 59  LEU n 
1 60  GLY n 
1 61  PHE n 
1 62  VAL n 
1 63  GLU n 
1 64  HIS n 
1 65  PHE n 
1 66  LEU n 
1 67  ALA n 
1 68  VAL n 
1 69  ASN n 
1 70  ARG n 
1 71  VAL n 
1 72  ILE n 
1 73  PRO n 
1 74  THR n 
1 75  ASN n 
1 76  VAL n 
1 77  PRO n 
1 78  GLU n 
1 79  LEU n 
1 80  THR n 
1 81  PHE n 
1 82  GLN n 
1 83  PRO n 
1 84  SER n 
1 85  PRO n 
1 86  ALA n 
1 87  PRO n 
1 88  ASP n 
1 89  PRO n 
1 90  PRO n 
1 91  GLY n 
1 92  GLY n 
1 93  LEU n 
1 94  THR n 
1 95  TYR n 
1 96  PHE n 
1 97  PRO n 
1 98  VAL n 
1 99  ALA n 
1 100 ASP n 
1 101 LEU n 
1 102 SER n 
1 103 ILE n 
1 104 ILE n 
1 105 ALA n 
1 106 ALA n 
1 107 LEU n 
1 108 TYR n 
1 109 ALA n 
1 110 ARG n 
1 111 PHE n 
1 112 THR n 
1 113 ALA n 
1 114 GLN n 
1 115 ILE n 
1 116 ARG n 
1 117 GLY n 
1 118 ALA n 
1 119 VAL n 
1 120 ASP n 
1 121 LEU n 
1 122 SER n 
1 123 LEU n 
1 124 TYR n 
1 125 PRO n 
1 126 ARG n 
1 127 GLU n 
1 128 GLY n 
1 129 GLY n 
1 130 VAL n 
1 131 SER n 
1 132 SER n 
1 133 ARG n 
1 134 GLU n 
1 135 LEU n 
1 136 VAL n 
1 137 LYS n 
1 138 LYS n 
1 139 VAL n 
1 140 SER n 
1 141 ASP n 
1 142 VAL n 
1 143 ILE n 
1 144 TRP n 
1 145 ASN n 
1 146 SER n 
1 147 LEU n 
1 148 SER n 
1 149 ARG n 
1 150 SER n 
1 151 TYR n 
1 152 PHE n 
1 153 LYS n 
1 154 ASP n 
1 155 ARG n 
1 156 ALA n 
1 157 HIS n 
1 158 ILE n 
1 159 GLN n 
1 160 SER n 
1 161 LEU n 
1 162 PHE n 
1 163 SER n 
1 164 PHE n 
1 165 ILE n 
1 166 THR n 
1 167 GLY n 
1 168 THR n 
1 169 LYS n 
1 170 LEU n 
1 171 ASP n 
1 172 SER n 
1 173 SER n 
1 174 GLY n 
1 175 VAL n 
1 176 ALA n 
1 177 PHE n 
1 178 ALA n 
1 179 VAL n 
1 180 VAL n 
1 181 GLY n 
1 182 ALA n 
1 183 CYS n 
1 184 GLN n 
1 185 ALA n 
1 186 LEU n 
1 187 GLY n 
1 188 LEU n 
1 189 ARG n 
1 190 ASP n 
1 191 VAL n 
1 192 HIS n 
1 193 LEU n 
1 194 ALA n 
1 195 LEU n 
1 196 SER n 
1 197 GLU n 
1 198 ASP n 
1 199 HIS n 
1 200 ALA n 
1 201 TRP n 
1 202 VAL n 
1 203 VAL n 
1 204 PHE n 
1 205 GLY n 
1 206 PRO n 
1 207 ASN n 
1 208 GLY n 
1 209 GLU n 
1 210 GLN n 
1 211 THR n 
1 212 ALA n 
1 213 GLU n 
1 214 VAL n 
1 215 THR n 
1 216 TRP n 
1 217 HIS n 
1 218 GLY n 
1 219 LYS n 
1 220 GLY n 
1 221 ASN n 
1 222 GLU n 
1 223 ASP n 
1 224 ARG n 
1 225 ARG n 
1 226 GLY n 
1 227 GLN n 
1 228 THR n 
1 229 VAL n 
1 230 ASN n 
1 231 ALA n 
1 232 GLY n 
1 233 VAL n 
1 234 ALA n 
1 235 GLU n 
1 236 ARG n 
1 237 SER n 
1 238 TRP n 
1 239 LEU n 
1 240 TYR n 
1 241 LEU n 
1 242 LYS n 
1 243 GLY n 
1 244 SER n 
1 245 TYR n 
1 246 MET n 
1 247 ARG n 
1 248 CYS n 
1 249 ASP n 
1 250 ARG n 
1 251 LYS n 
1 252 MET n 
1 253 GLU n 
1 254 VAL n 
1 255 ALA n 
1 256 PHE n 
1 257 MET n 
1 258 VAL n 
1 259 CYS n 
1 260 ALA n 
1 261 ILE n 
1 262 ASN n 
1 263 PRO n 
1 264 SER n 
1 265 ILE n 
1 266 ASP n 
1 267 LEU n 
1 268 HIS n 
1 269 THR n 
1 270 ASP n 
1 271 SER n 
1 272 LEU n 
1 273 GLU n 
1 274 LEU n 
1 275 LEU n 
1 276 GLN n 
1 277 LEU n 
1 278 GLN n 
1 279 GLN n 
1 280 LYS n 
1 281 LEU n 
1 282 LEU n 
1 283 TRP n 
1 284 LEU n 
1 285 LEU n 
1 286 TYR n 
1 287 ASP n 
1 288 LEU n 
1 289 GLY n 
1 290 HIS n 
1 291 LEU n 
1 292 GLU n 
1 293 ARG n 
1 294 TYR n 
1 295 PRO n 
1 296 MET n 
1 297 ALA n 
1 298 LEU n 
1 299 GLY n 
1 300 ASN n 
1 301 LEU n 
1 302 ALA n 
1 303 ASP n 
1 304 LEU n 
1 305 GLU n 
1 306 GLU n 
1 307 LEU n 
1 308 GLU n 
1 309 PRO n 
1 310 THR n 
1 311 PRO n 
1 312 GLY n 
1 313 ARG n 
1 314 PRO n 
1 315 ASP n 
1 316 PRO n 
1 317 LEU n 
1 318 THR n 
1 319 LEU n 
1 320 TYR n 
1 321 HIS n 
1 322 LYS n 
1 323 GLY n 
1 324 ILE n 
1 325 ALA n 
1 326 SER n 
1 327 ALA n 
1 328 LYS n 
1 329 THR n 
1 330 TYR n 
1 331 TYR n 
1 332 ARG n 
1 333 ASP n 
1 334 GLU n 
1 335 HIS n 
1 336 ILE n 
1 337 TYR n 
1 338 PRO n 
1 339 TYR n 
1 340 MET n 
1 341 TYR n 
1 342 LEU n 
1 343 ALA n 
1 344 GLY n 
1 345 TYR n 
1 346 HIS n 
1 347 CYS n 
1 348 ARG n 
1 349 ASN n 
1 350 ARG n 
1 351 ASN n 
1 352 VAL n 
1 353 ARG n 
1 354 GLU n 
1 355 ALA n 
1 356 LEU n 
1 357 GLN n 
1 358 ALA n 
1 359 TRP n 
1 360 ALA n 
1 361 ASP n 
1 362 THR n 
1 363 ALA n 
1 364 THR n 
1 365 VAL n 
1 366 ILE n 
1 367 GLN n 
1 368 ASP n 
1 369 TYR n 
1 370 ASN n 
1 371 TYR n 
1 372 CYS n 
1 373 ARG n 
1 374 GLU n 
1 375 ASP n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 TYR n 
1 380 LYS n 
1 381 GLU n 
1 382 PHE n 
1 383 PHE n 
1 384 GLU n 
1 385 VAL n 
1 386 ALA n 
1 387 ASN n 
1 388 ASP n 
1 389 VAL n 
1 390 ILE n 
1 391 PRO n 
1 392 ASN n 
1 393 LEU n 
1 394 LEU n 
1 395 LYS n 
1 396 GLU n 
1 397 ALA n 
1 398 ALA n 
1 399 SER n 
1 400 LEU n 
1 401 LEU n 
1 402 GLU n 
1 403 ALA n 
1 404 GLY n 
1 405 GLU n 
1 406 GLU n 
1 407 ARG n 
1 408 PRO n 
1 409 GLY n 
1 410 GLU n 
1 411 GLN n 
1 412 SER n 
1 413 GLN n 
1 414 GLY n 
1 415 THR n 
1 416 GLN n 
1 417 SER n 
1 418 GLN n 
1 419 GLY n 
1 420 SER n 
1 421 ALA n 
1 422 LEU n 
1 423 GLN n 
1 424 ASP n 
1 425 PRO n 
1 426 GLU n 
1 427 CYS n 
1 428 PHE n 
1 429 ALA n 
1 430 HIS n 
1 431 LEU n 
1 432 LEU n 
1 433 ARG n 
1 434 PHE n 
1 435 TYR n 
1 436 ASP n 
1 437 GLY n 
1 438 ILE n 
1 439 CYS n 
1 440 LYS n 
1 441 TRP n 
1 442 GLU n 
1 443 GLU n 
1 444 GLY n 
1 445 SER n 
1 446 PRO n 
1 447 THR n 
1 448 PRO n 
1 449 VAL n 
1 450 LEU n 
1 451 HIS n 
1 452 VAL n 
1 453 GLY n 
1 454 TRP n 
1 455 ALA n 
1 456 THR n 
1 457 PHE n 
1 458 LEU n 
1 459 VAL n 
1 460 GLN n 
1 461 SER n 
1 462 LEU n 
1 463 GLY n 
1 464 ARG n 
1 465 PHE n 
1 466 GLU n 
1 467 GLY n 
1 468 GLN n 
1 469 VAL n 
1 470 ARG n 
1 471 GLN n 
1 472 LYS n 
1 473 VAL n 
1 474 ARG n 
1 475 ILE n 
1 476 THR n 
1 477 PHE n 
1 478 GLN n 
1 479 SER n 
1 480 GLU n 
1 481 LYS n 
1 482 MET n 
1 483 LYS n 
1 484 GLY n 
1 485 MET n 
1 486 LYS n 
1 487 GLU n 
1 488 LEU n 
1 489 LEU n 
1 490 VAL n 
1 491 ALA n 
1 492 THR n 
1 493 LYS n 
1 494 ILE n 
1 495 ASN n 
1 496 SER n 
1 497 SER n 
1 498 ALA n 
1 499 ILE n 
1 500 LYS n 
1 501 LEU n 
1 502 GLN n 
1 503 LEU n 
1 504 THR n 
1 505 ALA n 
1 506 GLN n 
1 507 SER n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1   475 human ? 'MEN1, SCG2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli' 
562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
1 2 sample 'Biological sequence' 476 507 human ? 'MEN1, SCG2' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? 'Escherichia coli' 
562 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1AVF non-polymer         . 
;(1R,5R)-2-({5-fluoro-2-[(5-{7-[(1-methylcyclopropyl)methyl]-2,7-diazaspiro[3.5]nonan-2-yl}-1,2,4-triazin-6-yl)oxy]phenyl}methyl)-2-azabicyclo[3.1.0]hexan-3-one
;
?     'C27 H33 F N6 O2' 492.588 
ALA   'L-peptide linking' y ALANINE ?     'C3 H7 N O2'      89.093  
ARG   'L-peptide linking' y ARGININE ?     'C6 H15 N4 O2 1'  175.209 
ASN   'L-peptide linking' y ASPARAGINE ?     'C4 H8 N2 O3'     132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID' ?     'C4 H7 N O4'      133.103 
CYS   'L-peptide linking' y CYSTEINE ?     'C3 H7 N O2 S'    121.158 
EPE   non-polymer         . '4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID' HEPES 'C8 H18 N2 O4 S'  238.305 
GLN   'L-peptide linking' y GLUTAMINE ?     'C5 H10 N2 O3'    146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID' ?     'C5 H9 N O4'      147.129 
GLY   'peptide linking'   y GLYCINE ?     'C2 H5 N O2'      75.067  
HIS   'L-peptide linking' y HISTIDINE ?     'C6 H10 N3 O2 1'  156.162 
HOH   non-polymer         . WATER ?     'H2 O'            18.015  
ILE   'L-peptide linking' y ISOLEUCINE ?     'C6 H13 N O2'     131.173 
K     non-polymer         . 'POTASSIUM ION' ?     'K 1'             39.098  
LEU   'L-peptide linking' y LEUCINE ?     'C6 H13 N O2'     131.173 
LYS   'L-peptide linking' y LYSINE ?     'C6 H15 N2 O2 1'  147.195 
MET   'L-peptide linking' y METHIONINE ?     'C5 H11 N O2 S'   149.211 
PHE   'L-peptide linking' y PHENYLALANINE ?     'C9 H11 N O2'     165.189 
PRO   'L-peptide linking' y PROLINE ?     'C5 H9 N O2'      115.130 
SER   'L-peptide linking' y SERINE ?     'C3 H7 N O3'      105.093 
SO4   non-polymer         . 'SULFATE ION' ?     'O4 S -2'         96.063  
THR   'L-peptide linking' y THREONINE ?     'C4 H9 N O3'      119.119 
TRP   'L-peptide linking' y TRYPTOPHAN ?     'C11 H12 N2 O2'   204.225 
TYR   'L-peptide linking' y TYROSINE ?     'C9 H11 N O3'     181.189 
VAL   'L-peptide linking' y VALINE ?     'C5 H11 N O2'     117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -17 ?   ?   ?   A . n 
A 1 2   HIS 2   -16 ?   ?   ?   A . n 
A 1 3   HIS 3   -15 ?   ?   ?   A . n 
A 1 4   HIS 4   -14 ?   ?   ?   A . n 
A 1 5   HIS 5   -13 ?   ?   ?   A . n 
A 1 6   HIS 6   -12 ?   ?   ?   A . n 
A 1 7   HIS 7   -11 ?   ?   ?   A . n 
A 1 8   SER 8   -10 ?   ?   ?   A . n 
A 1 9   SER 9   -9  ?   ?   ?   A . n 
A 1 10  GLY 10  -8  ?   ?   ?   A . n 
A 1 11  ARG 11  -7  ?   ?   ?   A . n 
A 1 12  GLU 12  -6  ?   ?   ?   A . n 
A 1 13  ASN 13  -5  ?   ?   ?   A . n 
A 1 14  LEU 14  -4  ?   ?   ?   A . n 
A 1 15  TYR 15  -3  ?   ?   ?   A . n 
A 1 16  PHE 16  -2  ?   ?   ?   A . n 
A 1 17  GLN 17  -1  ?   ?   ?   A . n 
A 1 18  GLY 18  0   ?   ?   ?   A . n 
A 1 19  SER 19  1   ?   ?   ?   A . n 
A 1 20  GLY 20  2   2   GLY GLY A . n 
A 1 21  LEU 21  3   3   LEU LEU A . n 
A 1 22  LYS 22  4   4   LYS LYS A . n 
A 1 23  THR 23  5   5   THR THR A . n 
A 1 24  ALA 24  6   6   ALA ALA A . n 
A 1 25  GLN 25  7   7   GLN GLN A . n 
A 1 26  LYS 26  8   8   LYS LYS A . n 
A 1 27  THR 27  9   9   THR THR A . n 
A 1 28  LEU 28  10  10  LEU LEU A . n 
A 1 29  PHE 29  11  11  PHE PHE A . n 
A 1 30  PRO 30  12  12  PRO PRO A . n 
A 1 31  LEU 31  13  13  LEU LEU A . n 
A 1 32  ARG 32  14  14  ARG ARG A . n 
A 1 33  SER 33  15  15  SER SER A . n 
A 1 34  ILE 34  16  16  ILE ILE A . n 
A 1 35  ASP 35  17  17  ASP ASP A . n 
A 1 36  ASP 36  18  18  ASP ASP A . n 
A 1 37  VAL 37  19  19  VAL VAL A . n 
A 1 38  VAL 38  20  20  VAL VAL A . n 
A 1 39  ARG 39  21  21  ARG ARG A . n 
A 1 40  LEU 40  22  22  LEU LEU A . n 
A 1 41  PHE 41  23  23  PHE PHE A . n 
A 1 42  ALA 42  24  24  ALA ALA A . n 
A 1 43  ALA 43  25  25  ALA ALA A . n 
A 1 44  GLU 44  26  26  GLU GLU A . n 
A 1 45  LEU 45  27  27  LEU LEU A . n 
A 1 46  GLY 46  28  28  GLY GLY A . n 
A 1 47  ARG 47  29  29  ARG ARG A . n 
A 1 48  GLU 48  30  30  GLU GLU A . n 
A 1 49  GLU 49  31  31  GLU GLU A . n 
A 1 50  PRO 50  32  32  PRO PRO A . n 
A 1 51  ASP 51  33  33  ASP ASP A . n 
A 1 52  LEU 52  34  34  LEU LEU A . n 
A 1 53  VAL 53  35  35  VAL VAL A . n 
A 1 54  LEU 54  36  36  LEU LEU A . n 
A 1 55  LEU 55  37  37  LEU LEU A . n 
A 1 56  SER 56  38  38  SER SER A . n 
A 1 57  LEU 57  39  39  LEU LEU A . n 
A 1 58  VAL 58  40  40  VAL VAL A . n 
A 1 59  LEU 59  41  41  LEU LEU A . n 
A 1 60  GLY 60  42  42  GLY GLY A . n 
A 1 61  PHE 61  43  43  PHE PHE A . n 
A 1 62  VAL 62  44  44  VAL VAL A . n 
A 1 63  GLU 63  45  45  GLU GLU A . n 
A 1 64  HIS 64  46  46  HIS HIS A . n 
A 1 65  PHE 65  47  47  PHE PHE A . n 
A 1 66  LEU 66  48  48  LEU LEU A . n 
A 1 67  ALA 67  49  49  ALA ALA A . n 
A 1 68  VAL 68  50  50  VAL VAL A . n 
A 1 69  ASN 69  51  51  ASN ASN A . n 
A 1 70  ARG 70  52  52  ARG ARG A . n 
A 1 71  VAL 71  53  53  VAL VAL A . n 
A 1 72  ILE 72  54  54  ILE ILE A . n 
A 1 73  PRO 73  55  55  PRO PRO A . n 
A 1 74  THR 74  56  56  THR THR A . n 
A 1 75  ASN 75  57  ?   ?   ?   A . n 
A 1 76  VAL 76  58  ?   ?   ?   A . n 
A 1 77  PRO 77  59  59  PRO PRO A . n 
A 1 78  GLU 78  60  60  GLU GLU A . n 
A 1 79  LEU 79  61  ?   ?   ?   A . n 
A 1 80  THR 80  62  ?   ?   ?   A . n 
A 1 81  PHE 81  63  63  PHE PHE A . n 
A 1 82  GLN 82  64  64  GLN GLN A . n 
A 1 83  PRO 83  65  65  PRO PRO A . n 
A 1 84  SER 84  66  66  SER SER A . n 
A 1 85  PRO 85  67  67  PRO PRO A . n 
A 1 86  ALA 86  68  68  ALA ALA A . n 
A 1 87  PRO 87  69  69  PRO PRO A . n 
A 1 88  ASP 88  70  70  ASP ASP A . n 
A 1 89  PRO 89  71  71  PRO PRO A . n 
A 1 90  PRO 90  72  72  PRO PRO A . n 
A 1 91  GLY 91  73  73  GLY GLY A . n 
A 1 92  GLY 92  74  74  GLY GLY A . n 
A 1 93  LEU 93  75  75  LEU LEU A . n 
A 1 94  THR 94  76  76  THR THR A . n 
A 1 95  TYR 95  77  77  TYR TYR A . n 
A 1 96  PHE 96  78  78  PHE PHE A . n 
A 1 97  PRO 97  79  79  PRO PRO A . n 
A 1 98  VAL 98  80  80  VAL VAL A . n 
A 1 99  ALA 99  81  81  ALA ALA A . n 
A 1 100 ASP 100 82  82  ASP ASP A . n 
A 1 101 LEU 101 83  83  LEU LEU A . n 
A 1 102 SER 102 84  84  SER SER A . n 
A 1 103 ILE 103 85  85  ILE ILE A . n 
A 1 104 ILE 104 86  86  ILE ILE A . n 
A 1 105 ALA 105 87  87  ALA ALA A . n 
A 1 106 ALA 106 88  88  ALA ALA A . n 
A 1 107 LEU 107 89  89  LEU LEU A . n 
A 1 108 TYR 108 90  90  TYR TYR A . n 
A 1 109 ALA 109 91  91  ALA ALA A . n 
A 1 110 ARG 110 92  92  ARG ARG A . n 
A 1 111 PHE 111 93  93  PHE PHE A . n 
A 1 112 THR 112 94  94  THR THR A . n 
A 1 113 ALA 113 95  95  ALA ALA A . n 
A 1 114 GLN 114 96  96  GLN GLN A . n 
A 1 115 ILE 115 97  97  ILE ILE A . n 
A 1 116 ARG 116 98  98  ARG ARG A . n 
A 1 117 GLY 117 99  99  GLY GLY A . n 
A 1 118 ALA 118 100 100 ALA ALA A . n 
A 1 119 VAL 119 101 101 VAL VAL A . n 
A 1 120 ASP 120 102 102 ASP ASP A . n 
A 1 121 LEU 121 103 103 LEU LEU A . n 
A 1 122 SER 122 104 ?   ?   ?   A . n 
A 1 123 LEU 123 105 ?   ?   ?   A . n 
A 1 124 TYR 124 106 ?   ?   ?   A . n 
A 1 125 PRO 125 107 ?   ?   ?   A . n 
A 1 126 ARG 126 108 ?   ?   ?   A . n 
A 1 127 GLU 127 109 ?   ?   ?   A . n 
A 1 128 GLY 128 110 ?   ?   ?   A . n 
A 1 129 GLY 129 111 111 GLY GLY A . n 
A 1 130 VAL 130 112 112 VAL VAL A . n 
A 1 131 SER 131 113 113 SER SER A . n 
A 1 132 SER 132 114 114 SER SER A . n 
A 1 133 ARG 133 115 115 ARG ARG A . n 
A 1 134 GLU 134 116 116 GLU GLU A . n 
A 1 135 LEU 135 117 117 LEU LEU A . n 
A 1 136 VAL 136 118 118 VAL VAL A . n 
A 1 137 LYS 137 119 119 LYS LYS A . n 
A 1 138 LYS 138 120 120 LYS LYS A . n 
A 1 139 VAL 139 121 121 VAL VAL A . n 
A 1 140 SER 140 122 122 SER SER A . n 
A 1 141 ASP 141 123 123 ASP ASP A . n 
A 1 142 VAL 142 124 124 VAL VAL A . n 
A 1 143 ILE 143 125 125 ILE ILE A . n 
A 1 144 TRP 144 126 126 TRP TRP A . n 
A 1 145 ASN 145 127 127 ASN ASN A . n 
A 1 146 SER 146 128 128 SER SER A . n 
A 1 147 LEU 147 129 129 LEU LEU A . n 
A 1 148 SER 148 130 130 SER SER A . n 
A 1 149 ARG 149 131 131 ARG ARG A . n 
A 1 150 SER 150 132 132 SER SER A . n 
A 1 151 TYR 151 133 133 TYR TYR A . n 
A 1 152 PHE 152 134 134 PHE PHE A . n 
A 1 153 LYS 153 135 135 LYS LYS A . n 
A 1 154 ASP 154 136 136 ASP ASP A . n 
A 1 155 ARG 155 137 137 ARG ARG A . n 
A 1 156 ALA 156 138 138 ALA ALA A . n 
A 1 157 HIS 157 139 139 HIS HIS A . n 
A 1 158 ILE 158 140 140 ILE ILE A . n 
A 1 159 GLN 159 141 141 GLN GLN A . n 
A 1 160 SER 160 142 142 SER SER A . n 
A 1 161 LEU 161 143 143 LEU LEU A . n 
A 1 162 PHE 162 144 144 PHE PHE A . n 
A 1 163 SER 163 145 145 SER SER A . n 
A 1 164 PHE 164 146 146 PHE PHE A . n 
A 1 165 ILE 165 147 147 ILE ILE A . n 
A 1 166 THR 166 148 148 THR THR A . n 
A 1 167 GLY 167 149 149 GLY GLY A . n 
A 1 168 THR 168 150 150 THR THR A . n 
A 1 169 LYS 169 151 151 LYS LYS A . n 
A 1 170 LEU 170 152 152 LEU LEU A . n 
A 1 171 ASP 171 153 153 ASP ASP A . n 
A 1 172 SER 172 154 154 SER SER A . n 
A 1 173 SER 173 155 155 SER SER A . n 
A 1 174 GLY 174 156 156 GLY GLY A . n 
A 1 175 VAL 175 157 157 VAL VAL A . n 
A 1 176 ALA 176 158 158 ALA ALA A . n 
A 1 177 PHE 177 159 159 PHE PHE A . n 
A 1 178 ALA 178 160 160 ALA ALA A . n 
A 1 179 VAL 179 161 161 VAL VAL A . n 
A 1 180 VAL 180 162 162 VAL VAL A . n 
A 1 181 GLY 181 163 163 GLY GLY A . n 
A 1 182 ALA 182 164 164 ALA ALA A . n 
A 1 183 CYS 183 165 165 CYS CYS A . n 
A 1 184 GLN 184 166 166 GLN GLN A . n 
A 1 185 ALA 185 167 167 ALA ALA A . n 
A 1 186 LEU 186 168 168 LEU LEU A . n 
A 1 187 GLY 187 169 169 GLY GLY A . n 
A 1 188 LEU 188 170 170 LEU LEU A . n 
A 1 189 ARG 189 171 171 ARG ARG A . n 
A 1 190 ASP 190 172 172 ASP ASP A . n 
A 1 191 VAL 191 173 173 VAL VAL A . n 
A 1 192 HIS 192 174 174 HIS HIS A . n 
A 1 193 LEU 193 175 175 LEU LEU A . n 
A 1 194 ALA 194 176 176 ALA ALA A . n 
A 1 195 LEU 195 177 177 LEU LEU A . n 
A 1 196 SER 196 178 178 SER SER A . n 
A 1 197 GLU 197 179 179 GLU GLU A . n 
A 1 198 ASP 198 180 180 ASP ASP A . n 
A 1 199 HIS 199 181 181 HIS HIS A . n 
A 1 200 ALA 200 182 182 ALA ALA A . n 
A 1 201 TRP 201 183 183 TRP TRP A . n 
A 1 202 VAL 202 184 184 VAL VAL A . n 
A 1 203 VAL 203 185 185 VAL VAL A . n 
A 1 204 PHE 204 186 186 PHE PHE A . n 
A 1 205 GLY 205 187 187 GLY GLY A . n 
A 1 206 PRO 206 188 188 PRO PRO A . n 
A 1 207 ASN 207 189 189 ASN ASN A . n 
A 1 208 GLY 208 190 190 GLY GLY A . n 
A 1 209 GLU 209 191 191 GLU GLU A . n 
A 1 210 GLN 210 192 192 GLN GLN A . n 
A 1 211 THR 211 193 193 THR THR A . n 
A 1 212 ALA 212 194 194 ALA ALA A . n 
A 1 213 GLU 213 195 195 GLU GLU A . n 
A 1 214 VAL 214 196 196 VAL VAL A . n 
A 1 215 THR 215 197 197 THR THR A . n 
A 1 216 TRP 216 198 198 TRP TRP A . n 
A 1 217 HIS 217 199 199 HIS HIS A . n 
A 1 218 GLY 218 200 200 GLY GLY A . n 
A 1 219 LYS 219 201 ?   ?   ?   A . n 
A 1 220 GLY 220 202 ?   ?   ?   A . n 
A 1 221 ASN 221 203 ?   ?   ?   A . n 
A 1 222 GLU 222 204 204 GLU GLU A . n 
A 1 223 ASP 223 205 205 ASP ASP A . n 
A 1 224 ARG 224 206 206 ARG ARG A . n 
A 1 225 ARG 225 207 207 ARG ARG A . n 
A 1 226 GLY 226 208 208 GLY GLY A . n 
A 1 227 GLN 227 209 209 GLN GLN A . n 
A 1 228 THR 228 210 210 THR THR A . n 
A 1 229 VAL 229 211 211 VAL VAL A . n 
A 1 230 ASN 230 212 212 ASN ASN A . n 
A 1 231 ALA 231 213 213 ALA ALA A . n 
A 1 232 GLY 232 214 214 GLY GLY A . n 
A 1 233 VAL 233 215 215 VAL VAL A . n 
A 1 234 ALA 234 216 216 ALA ALA A . n 
A 1 235 GLU 235 217 217 GLU GLU A . n 
A 1 236 ARG 236 218 218 ARG ARG A . n 
A 1 237 SER 237 219 219 SER SER A . n 
A 1 238 TRP 238 220 220 TRP TRP A . n 
A 1 239 LEU 239 221 221 LEU LEU A . n 
A 1 240 TYR 240 222 222 TYR TYR A . n 
A 1 241 LEU 241 223 223 LEU LEU A . n 
A 1 242 LYS 242 224 224 LYS LYS A . n 
A 1 243 GLY 243 225 225 GLY GLY A . n 
A 1 244 SER 244 226 226 SER SER A . n 
A 1 245 TYR 245 227 227 TYR TYR A . n 
A 1 246 MET 246 228 228 MET MET A . n 
A 1 247 ARG 247 229 229 ARG ARG A . n 
A 1 248 CYS 248 230 230 CYS CYS A . n 
A 1 249 ASP 249 231 231 ASP ASP A . n 
A 1 250 ARG 250 232 232 ARG ARG A . n 
A 1 251 LYS 251 233 233 LYS LYS A . n 
A 1 252 MET 252 234 234 MET MET A . n 
A 1 253 GLU 253 235 235 GLU GLU A . n 
A 1 254 VAL 254 236 236 VAL VAL A . n 
A 1 255 ALA 255 237 237 ALA ALA A . n 
A 1 256 PHE 256 238 238 PHE PHE A . n 
A 1 257 MET 257 239 239 MET MET A . n 
A 1 258 VAL 258 240 240 VAL VAL A . n 
A 1 259 CYS 259 241 241 CYS CYS A . n 
A 1 260 ALA 260 242 242 ALA ALA A . n 
A 1 261 ILE 261 243 243 ILE ILE A . n 
A 1 262 ASN 262 244 244 ASN ASN A . n 
A 1 263 PRO 263 245 245 PRO PRO A . n 
A 1 264 SER 264 246 246 SER SER A . n 
A 1 265 ILE 265 247 247 ILE ILE A . n 
A 1 266 ASP 266 248 248 ASP ASP A . n 
A 1 267 LEU 267 249 249 LEU LEU A . n 
A 1 268 HIS 268 250 250 HIS HIS A . n 
A 1 269 THR 269 251 251 THR THR A . n 
A 1 270 ASP 270 252 252 ASP ASP A . n 
A 1 271 SER 271 253 253 SER SER A . n 
A 1 272 LEU 272 254 254 LEU LEU A . n 
A 1 273 GLU 273 255 255 GLU GLU A . n 
A 1 274 LEU 274 256 256 LEU LEU A . n 
A 1 275 LEU 275 257 257 LEU LEU A . n 
A 1 276 GLN 276 258 258 GLN GLN A . n 
A 1 277 LEU 277 259 259 LEU LEU A . n 
A 1 278 GLN 278 260 260 GLN GLN A . n 
A 1 279 GLN 279 261 261 GLN GLN A . n 
A 1 280 LYS 280 262 262 LYS LYS A . n 
A 1 281 LEU 281 263 263 LEU LEU A . n 
A 1 282 LEU 282 264 264 LEU LEU A . n 
A 1 283 TRP 283 265 265 TRP TRP A . n 
A 1 284 LEU 284 266 266 LEU LEU A . n 
A 1 285 LEU 285 267 267 LEU LEU A . n 
A 1 286 TYR 286 268 268 TYR TYR A . n 
A 1 287 ASP 287 269 269 ASP ASP A . n 
A 1 288 LEU 288 270 270 LEU LEU A . n 
A 1 289 GLY 289 271 271 GLY GLY A . n 
A 1 290 HIS 290 272 272 HIS HIS A . n 
A 1 291 LEU 291 273 273 LEU LEU A . n 
A 1 292 GLU 292 274 274 GLU GLU A . n 
A 1 293 ARG 293 275 275 ARG ARG A . n 
A 1 294 TYR 294 276 276 TYR TYR A . n 
A 1 295 PRO 295 277 277 PRO PRO A . n 
A 1 296 MET 296 278 278 MET MET A . n 
A 1 297 ALA 297 279 279 ALA ALA A . n 
A 1 298 LEU 298 280 280 LEU LEU A . n 
A 1 299 GLY 299 281 281 GLY GLY A . n 
A 1 300 ASN 300 282 282 ASN ASN A . n 
A 1 301 LEU 301 283 283 LEU LEU A . n 
A 1 302 ALA 302 284 284 ALA ALA A . n 
A 1 303 ASP 303 285 285 ASP ASP A . n 
A 1 304 LEU 304 286 286 LEU LEU A . n 
A 1 305 GLU 305 287 287 GLU GLU A . n 
A 1 306 GLU 306 288 288 GLU GLU A . n 
A 1 307 LEU 307 289 289 LEU LEU A . n 
A 1 308 GLU 308 290 290 GLU GLU A . n 
A 1 309 PRO 309 291 291 PRO PRO A . n 
A 1 310 THR 310 292 292 THR THR A . n 
A 1 311 PRO 311 293 293 PRO PRO A . n 
A 1 312 GLY 312 294 294 GLY GLY A . n 
A 1 313 ARG 313 295 295 ARG ARG A . n 
A 1 314 PRO 314 296 296 PRO PRO A . n 
A 1 315 ASP 315 297 297 ASP ASP A . n 
A 1 316 PRO 316 298 298 PRO PRO A . n 
A 1 317 LEU 317 299 299 LEU LEU A . n 
A 1 318 THR 318 300 300 THR THR A . n 
A 1 319 LEU 319 301 301 LEU LEU A . n 
A 1 320 TYR 320 302 302 TYR TYR A . n 
A 1 321 HIS 321 303 303 HIS HIS A . n 
A 1 322 LYS 322 304 304 LYS LYS A . n 
A 1 323 GLY 323 305 305 GLY GLY A . n 
A 1 324 ILE 324 306 306 ILE ILE A . n 
A 1 325 ALA 325 307 307 ALA ALA A . n 
A 1 326 SER 326 308 308 SER SER A . n 
A 1 327 ALA 327 309 309 ALA ALA A . n 
A 1 328 LYS 328 310 310 LYS LYS A . n 
A 1 329 THR 329 311 311 THR THR A . n 
A 1 330 TYR 330 312 312 TYR TYR A . n 
A 1 331 TYR 331 313 313 TYR TYR A . n 
A 1 332 ARG 332 314 314 ARG ARG A . n 
A 1 333 ASP 333 315 315 ASP ASP A . n 
A 1 334 GLU 334 316 316 GLU GLU A . n 
A 1 335 HIS 335 317 317 HIS HIS A . n 
A 1 336 ILE 336 318 318 ILE ILE A . n 
A 1 337 TYR 337 319 319 TYR TYR A . n 
A 1 338 PRO 338 320 320 PRO PRO A . n 
A 1 339 TYR 339 321 321 TYR TYR A . n 
A 1 340 MET 340 322 322 MET MET A . n 
A 1 341 TYR 341 323 323 TYR TYR A . n 
A 1 342 LEU 342 324 324 LEU LEU A . n 
A 1 343 ALA 343 325 325 ALA ALA A . n 
A 1 344 GLY 344 326 326 GLY GLY A . n 
A 1 345 TYR 345 327 327 TYR TYR A . n 
A 1 346 HIS 346 328 328 HIS HIS A . n 
A 1 347 CYS 347 329 329 CYS CYS A . n 
A 1 348 ARG 348 330 330 ARG ARG A . n 
A 1 349 ASN 349 331 331 ASN ASN A . n 
A 1 350 ARG 350 332 332 ARG ARG A . n 
A 1 351 ASN 351 333 333 ASN ASN A . n 
A 1 352 VAL 352 334 334 VAL VAL A . n 
A 1 353 ARG 353 335 335 ARG ARG A . n 
A 1 354 GLU 354 336 336 GLU GLU A . n 
A 1 355 ALA 355 337 337 ALA ALA A . n 
A 1 356 LEU 356 338 338 LEU LEU A . n 
A 1 357 GLN 357 339 339 GLN GLN A . n 
A 1 358 ALA 358 340 340 ALA ALA A . n 
A 1 359 TRP 359 341 341 TRP TRP A . n 
A 1 360 ALA 360 342 342 ALA ALA A . n 
A 1 361 ASP 361 343 343 ASP ASP A . n 
A 1 362 THR 362 344 344 THR THR A . n 
A 1 363 ALA 363 345 345 ALA ALA A . n 
A 1 364 THR 364 346 346 THR THR A . n 
A 1 365 VAL 365 347 347 VAL VAL A . n 
A 1 366 ILE 366 348 348 ILE ILE A . n 
A 1 367 GLN 367 349 349 GLN GLN A . n 
A 1 368 ASP 368 350 350 ASP ASP A . n 
A 1 369 TYR 369 351 351 TYR TYR A . n 
A 1 370 ASN 370 352 352 ASN ASN A . n 
A 1 371 TYR 371 353 353 TYR TYR A . n 
A 1 372 CYS 372 354 354 CYS CYS A . n 
A 1 373 ARG 373 355 355 ARG ARG A . n 
A 1 374 GLU 374 356 356 GLU GLU A . n 
A 1 375 ASP 375 357 357 ASP ASP A . n 
A 1 376 GLU 376 358 358 GLU GLU A . n 
A 1 377 GLU 377 359 359 GLU GLU A . n 
A 1 378 ILE 378 360 360 ILE ILE A . n 
A 1 379 TYR 379 361 361 TYR TYR A . n 
A 1 380 LYS 380 362 362 LYS LYS A . n 
A 1 381 GLU 381 363 363 GLU GLU A . n 
A 1 382 PHE 382 364 364 PHE PHE A . n 
A 1 383 PHE 383 365 365 PHE PHE A . n 
A 1 384 GLU 384 366 366 GLU GLU A . n 
A 1 385 VAL 385 367 367 VAL VAL A . n 
A 1 386 ALA 386 368 368 ALA ALA A . n 
A 1 387 ASN 387 369 369 ASN ASN A . n 
A 1 388 ASP 388 370 370 ASP ASP A . n 
A 1 389 VAL 389 371 371 VAL VAL A . n 
A 1 390 ILE 390 372 372 ILE ILE A . n 
A 1 391 PRO 391 373 373 PRO PRO A . n 
A 1 392 ASN 392 374 374 ASN ASN A . n 
A 1 393 LEU 393 375 375 LEU LEU A . n 
A 1 394 LEU 394 376 376 LEU LEU A . n 
A 1 395 LYS 395 377 377 LYS LYS A . n 
A 1 396 GLU 396 378 378 GLU GLU A . n 
A 1 397 ALA 397 379 379 ALA ALA A . n 
A 1 398 ALA 398 380 380 ALA ALA A . n 
A 1 399 SER 399 381 381 SER SER A . n 
A 1 400 LEU 400 382 382 LEU LEU A . n 
A 1 401 LEU 401 383 383 LEU LEU A . n 
A 1 402 GLU 402 384 384 GLU GLU A . n 
A 1 403 ALA 403 385 385 ALA ALA A . n 
A 1 404 GLY 404 386 ?   ?   ?   A . n 
A 1 405 GLU 405 387 ?   ?   ?   A . n 
A 1 406 GLU 406 388 ?   ?   ?   A . n 
A 1 407 ARG 407 389 ?   ?   ?   A . n 
A 1 408 PRO 408 390 ?   ?   ?   A . n 
A 1 409 GLY 409 391 ?   ?   ?   A . n 
A 1 410 GLU 410 392 ?   ?   ?   A . n 
A 1 411 GLN 411 393 ?   ?   ?   A . n 
A 1 412 SER 412 394 ?   ?   ?   A . n 
A 1 413 GLN 413 395 ?   ?   ?   A . n 
A 1 414 GLY 414 396 ?   ?   ?   A . n 
A 1 415 THR 415 397 ?   ?   ?   A . n 
A 1 416 GLN 416 398 ?   ?   ?   A . n 
A 1 417 SER 417 399 ?   ?   ?   A . n 
A 1 418 GLN 418 400 ?   ?   ?   A . n 
A 1 419 GLY 419 401 401 GLY GLY A . n 
A 1 420 SER 420 402 402 SER SER A . n 
A 1 421 ALA 421 403 403 ALA ALA A . n 
A 1 422 LEU 422 404 404 LEU LEU A . n 
A 1 423 GLN 423 405 405 GLN GLN A . n 
A 1 424 ASP 424 406 406 ASP ASP A . n 
A 1 425 PRO 425 407 407 PRO PRO A . n 
A 1 426 GLU 426 408 408 GLU GLU A . n 
A 1 427 CYS 427 409 409 CYS CYS A . n 
A 1 428 PHE 428 410 410 PHE PHE A . n 
A 1 429 ALA 429 411 411 ALA ALA A . n 
A 1 430 HIS 430 412 412 HIS HIS A . n 
A 1 431 LEU 431 413 413 LEU LEU A . n 
A 1 432 LEU 432 414 414 LEU LEU A . n 
A 1 433 ARG 433 415 415 ARG ARG A . n 
A 1 434 PHE 434 416 416 PHE PHE A . n 
A 1 435 TYR 435 417 417 TYR TYR A . n 
A 1 436 ASP 436 418 418 ASP ASP A . n 
A 1 437 GLY 437 419 419 GLY GLY A . n 
A 1 438 ILE 438 420 420 ILE ILE A . n 
A 1 439 CYS 439 421 421 CYS CYS A . n 
A 1 440 LYS 440 422 422 LYS LYS A . n 
A 1 441 TRP 441 423 423 TRP TRP A . n 
A 1 442 GLU 442 424 424 GLU GLU A . n 
A 1 443 GLU 443 425 425 GLU GLU A . n 
A 1 444 GLY 444 426 426 GLY GLY A . n 
A 1 445 SER 445 427 427 SER SER A . n 
A 1 446 PRO 446 428 428 PRO PRO A . n 
A 1 447 THR 447 429 429 THR THR A . n 
A 1 448 PRO 448 430 430 PRO PRO A . n 
A 1 449 VAL 449 431 431 VAL VAL A . n 
A 1 450 LEU 450 432 432 LEU LEU A . n 
A 1 451 HIS 451 433 433 HIS HIS A . n 
A 1 452 VAL 452 434 434 VAL VAL A . n 
A 1 453 GLY 453 435 435 GLY GLY A . n 
A 1 454 TRP 454 436 436 TRP TRP A . n 
A 1 455 ALA 455 437 437 ALA ALA A . n 
A 1 456 THR 456 438 438 THR THR A . n 
A 1 457 PHE 457 439 439 PHE PHE A . n 
A 1 458 LEU 458 440 440 LEU LEU A . n 
A 1 459 VAL 459 441 441 VAL VAL A . n 
A 1 460 GLN 460 442 442 GLN GLN A . n 
A 1 461 SER 461 443 443 SER SER A . n 
A 1 462 LEU 462 444 444 LEU LEU A . n 
A 1 463 GLY 463 445 445 GLY GLY A . n 
A 1 464 ARG 464 446 446 ARG ARG A . n 
A 1 465 PHE 465 447 447 PHE PHE A . n 
A 1 466 GLU 466 448 448 GLU GLU A . n 
A 1 467 GLY 467 449 449 GLY GLY A . n 
A 1 468 GLN 468 450 450 GLN GLN A . n 
A 1 469 VAL 469 451 451 VAL VAL A . n 
A 1 470 ARG 470 452 452 ARG ARG A . n 
A 1 471 GLN 471 453 453 GLN GLN A . n 
A 1 472 LYS 472 454 454 LYS LYS A . n 
A 1 473 VAL 473 455 455 VAL VAL A . n 
A 1 474 ARG 474 456 456 ARG ARG A . n 
A 1 475 ILE 475 457 457 ILE ILE A . n 
A 1 476 THR 476 552 552 THR THR A . n 
A 1 477 PHE 477 553 553 PHE PHE A . n 
A 1 478 GLN 478 554 554 GLN GLN A . n 
A 1 479 SER 479 555 555 SER SER A . n 
A 1 480 GLU 480 556 556 GLU GLU A . n 
A 1 481 LYS 481 557 557 LYS LYS A . n 
A 1 482 MET 482 558 558 MET MET A . n 
A 1 483 LYS 483 559 559 LYS LYS A . n 
A 1 484 GLY 484 560 560 GLY GLY A . n 
A 1 485 MET 485 561 561 MET MET A . n 
A 1 486 LYS 486 562 562 LYS LYS A . n 
A 1 487 GLU 487 563 563 GLU GLU A . n 
A 1 488 LEU 488 564 564 LEU LEU A . n 
A 1 489 LEU 489 565 565 LEU LEU A . n 
A 1 490 VAL 490 566 566 VAL VAL A . n 
A 1 491 ALA 491 567 567 ALA ALA A . n 
A 1 492 THR 492 568 568 THR THR A . n 
A 1 493 LYS 493 569 569 LYS LYS A . n 
A 1 494 ILE 494 570 570 ILE ILE A . n 
A 1 495 ASN 495 571 571 ASN ASN A . n 
A 1 496 SER 496 572 572 SER SER A . n 
A 1 497 SER 497 573 573 SER SER A . n 
A 1 498 ALA 498 574 574 ALA ALA A . n 
A 1 499 ILE 499 575 575 ILE ILE A . n 
A 1 500 LYS 500 576 576 LYS LYS A . n 
A 1 501 LEU 501 577 577 LEU LEU A . n 
A 1 502 GLN 502 578 578 GLN GLN A . n 
A 1 503 LEU 503 579 579 LEU LEU A . n 
A 1 504 THR 504 580 580 THR THR A . n 
A 1 505 ALA 505 581 581 ALA ALA A . n 
A 1 506 GLN 506 582 582 GLN GLN A . n 
A 1 507 SER 507 583 583 SER SER A . n 
B 1 1   MET 1   -17 ?   ?   ?   B . n 
B 1 2   HIS 2   -16 ?   ?   ?   B . n 
B 1 3   HIS 3   -15 ?   ?   ?   B . n 
B 1 4   HIS 4   -14 ?   ?   ?   B . n 
B 1 5   HIS 5   -13 ?   ?   ?   B . n 
B 1 6   HIS 6   -12 ?   ?   ?   B . n 
B 1 7   HIS 7   -11 ?   ?   ?   B . n 
B 1 8   SER 8   -10 ?   ?   ?   B . n 
B 1 9   SER 9   -9  ?   ?   ?   B . n 
B 1 10  GLY 10  -8  ?   ?   ?   B . n 
B 1 11  ARG 11  -7  ?   ?   ?   B . n 
B 1 12  GLU 12  -6  ?   ?   ?   B . n 
B 1 13  ASN 13  -5  ?   ?   ?   B . n 
B 1 14  LEU 14  -4  ?   ?   ?   B . n 
B 1 15  TYR 15  -3  ?   ?   ?   B . n 
B 1 16  PHE 16  -2  ?   ?   ?   B . n 
B 1 17  GLN 17  -1  ?   ?   ?   B . n 
B 1 18  GLY 18  0   ?   ?   ?   B . n 
B 1 19  SER 19  1   ?   ?   ?   B . n 
B 1 20  GLY 20  2   ?   ?   ?   B . n 
B 1 21  LEU 21  3   3   LEU LEU B . n 
B 1 22  LYS 22  4   4   LYS LYS B . n 
B 1 23  THR 23  5   5   THR THR B . n 
B 1 24  ALA 24  6   6   ALA ALA B . n 
B 1 25  GLN 25  7   7   GLN GLN B . n 
B 1 26  LYS 26  8   8   LYS LYS B . n 
B 1 27  THR 27  9   9   THR THR B . n 
B 1 28  LEU 28  10  10  LEU LEU B . n 
B 1 29  PHE 29  11  11  PHE PHE B . n 
B 1 30  PRO 30  12  12  PRO PRO B . n 
B 1 31  LEU 31  13  13  LEU LEU B . n 
B 1 32  ARG 32  14  14  ARG ARG B . n 
B 1 33  SER 33  15  15  SER SER B . n 
B 1 34  ILE 34  16  16  ILE ILE B . n 
B 1 35  ASP 35  17  17  ASP ASP B . n 
B 1 36  ASP 36  18  18  ASP ASP B . n 
B 1 37  VAL 37  19  19  VAL VAL B . n 
B 1 38  VAL 38  20  20  VAL VAL B . n 
B 1 39  ARG 39  21  21  ARG ARG B . n 
B 1 40  LEU 40  22  22  LEU LEU B . n 
B 1 41  PHE 41  23  23  PHE PHE B . n 
B 1 42  ALA 42  24  24  ALA ALA B . n 
B 1 43  ALA 43  25  25  ALA ALA B . n 
B 1 44  GLU 44  26  26  GLU GLU B . n 
B 1 45  LEU 45  27  27  LEU LEU B . n 
B 1 46  GLY 46  28  28  GLY GLY B . n 
B 1 47  ARG 47  29  29  ARG ARG B . n 
B 1 48  GLU 48  30  30  GLU GLU B . n 
B 1 49  GLU 49  31  31  GLU GLU B . n 
B 1 50  PRO 50  32  32  PRO PRO B . n 
B 1 51  ASP 51  33  33  ASP ASP B . n 
B 1 52  LEU 52  34  34  LEU LEU B . n 
B 1 53  VAL 53  35  35  VAL VAL B . n 
B 1 54  LEU 54  36  36  LEU LEU B . n 
B 1 55  LEU 55  37  37  LEU LEU B . n 
B 1 56  SER 56  38  38  SER SER B . n 
B 1 57  LEU 57  39  39  LEU LEU B . n 
B 1 58  VAL 58  40  40  VAL VAL B . n 
B 1 59  LEU 59  41  41  LEU LEU B . n 
B 1 60  GLY 60  42  42  GLY GLY B . n 
B 1 61  PHE 61  43  43  PHE PHE B . n 
B 1 62  VAL 62  44  44  VAL VAL B . n 
B 1 63  GLU 63  45  45  GLU GLU B . n 
B 1 64  HIS 64  46  46  HIS HIS B . n 
B 1 65  PHE 65  47  47  PHE PHE B . n 
B 1 66  LEU 66  48  48  LEU LEU B . n 
B 1 67  ALA 67  49  49  ALA ALA B . n 
B 1 68  VAL 68  50  50  VAL VAL B . n 
B 1 69  ASN 69  51  51  ASN ASN B . n 
B 1 70  ARG 70  52  52  ARG ARG B . n 
B 1 71  VAL 71  53  53  VAL VAL B . n 
B 1 72  ILE 72  54  54  ILE ILE B . n 
B 1 73  PRO 73  55  55  PRO PRO B . n 
B 1 74  THR 74  56  56  THR THR B . n 
B 1 75  ASN 75  57  57  ASN ASN B . n 
B 1 76  VAL 76  58  58  VAL VAL B . n 
B 1 77  PRO 77  59  59  PRO PRO B . n 
B 1 78  GLU 78  60  60  GLU GLU B . n 
B 1 79  LEU 79  61  61  LEU LEU B . n 
B 1 80  THR 80  62  62  THR THR B . n 
B 1 81  PHE 81  63  63  PHE PHE B . n 
B 1 82  GLN 82  64  64  GLN GLN B . n 
B 1 83  PRO 83  65  65  PRO PRO B . n 
B 1 84  SER 84  66  66  SER SER B . n 
B 1 85  PRO 85  67  67  PRO PRO B . n 
B 1 86  ALA 86  68  68  ALA ALA B . n 
B 1 87  PRO 87  69  69  PRO PRO B . n 
B 1 88  ASP 88  70  70  ASP ASP B . n 
B 1 89  PRO 89  71  71  PRO PRO B . n 
B 1 90  PRO 90  72  72  PRO PRO B . n 
B 1 91  GLY 91  73  73  GLY GLY B . n 
B 1 92  GLY 92  74  74  GLY GLY B . n 
B 1 93  LEU 93  75  75  LEU LEU B . n 
B 1 94  THR 94  76  76  THR THR B . n 
B 1 95  TYR 95  77  77  TYR TYR B . n 
B 1 96  PHE 96  78  78  PHE PHE B . n 
B 1 97  PRO 97  79  79  PRO PRO B . n 
B 1 98  VAL 98  80  80  VAL VAL B . n 
B 1 99  ALA 99  81  81  ALA ALA B . n 
B 1 100 ASP 100 82  82  ASP ASP B . n 
B 1 101 LEU 101 83  83  LEU LEU B . n 
B 1 102 SER 102 84  84  SER SER B . n 
B 1 103 ILE 103 85  85  ILE ILE B . n 
B 1 104 ILE 104 86  86  ILE ILE B . n 
B 1 105 ALA 105 87  87  ALA ALA B . n 
B 1 106 ALA 106 88  88  ALA ALA B . n 
B 1 107 LEU 107 89  89  LEU LEU B . n 
B 1 108 TYR 108 90  90  TYR TYR B . n 
B 1 109 ALA 109 91  91  ALA ALA B . n 
B 1 110 ARG 110 92  92  ARG ARG B . n 
B 1 111 PHE 111 93  93  PHE PHE B . n 
B 1 112 THR 112 94  94  THR THR B . n 
B 1 113 ALA 113 95  95  ALA ALA B . n 
B 1 114 GLN 114 96  96  GLN GLN B . n 
B 1 115 ILE 115 97  97  ILE ILE B . n 
B 1 116 ARG 116 98  98  ARG ARG B . n 
B 1 117 GLY 117 99  99  GLY GLY B . n 
B 1 118 ALA 118 100 100 ALA ALA B . n 
B 1 119 VAL 119 101 101 VAL VAL B . n 
B 1 120 ASP 120 102 102 ASP ASP B . n 
B 1 121 LEU 121 103 103 LEU LEU B . n 
B 1 122 SER 122 104 104 SER SER B . n 
B 1 123 LEU 123 105 105 LEU LEU B . n 
B 1 124 TYR 124 106 106 TYR TYR B . n 
B 1 125 PRO 125 107 ?   ?   ?   B . n 
B 1 126 ARG 126 108 ?   ?   ?   B . n 
B 1 127 GLU 127 109 ?   ?   ?   B . n 
B 1 128 GLY 128 110 ?   ?   ?   B . n 
B 1 129 GLY 129 111 ?   ?   ?   B . n 
B 1 130 VAL 130 112 112 VAL VAL B . n 
B 1 131 SER 131 113 113 SER SER B . n 
B 1 132 SER 132 114 114 SER SER B . n 
B 1 133 ARG 133 115 115 ARG ARG B . n 
B 1 134 GLU 134 116 116 GLU GLU B . n 
B 1 135 LEU 135 117 117 LEU LEU B . n 
B 1 136 VAL 136 118 118 VAL VAL B . n 
B 1 137 LYS 137 119 119 LYS LYS B . n 
B 1 138 LYS 138 120 120 LYS LYS B . n 
B 1 139 VAL 139 121 121 VAL VAL B . n 
B 1 140 SER 140 122 122 SER SER B . n 
B 1 141 ASP 141 123 123 ASP ASP B . n 
B 1 142 VAL 142 124 124 VAL VAL B . n 
B 1 143 ILE 143 125 125 ILE ILE B . n 
B 1 144 TRP 144 126 126 TRP TRP B . n 
B 1 145 ASN 145 127 127 ASN ASN B . n 
B 1 146 SER 146 128 128 SER SER B . n 
B 1 147 LEU 147 129 129 LEU LEU B . n 
B 1 148 SER 148 130 130 SER SER B . n 
B 1 149 ARG 149 131 131 ARG ARG B . n 
B 1 150 SER 150 132 132 SER SER B . n 
B 1 151 TYR 151 133 133 TYR TYR B . n 
B 1 152 PHE 152 134 134 PHE PHE B . n 
B 1 153 LYS 153 135 135 LYS LYS B . n 
B 1 154 ASP 154 136 136 ASP ASP B . n 
B 1 155 ARG 155 137 137 ARG ARG B . n 
B 1 156 ALA 156 138 138 ALA ALA B . n 
B 1 157 HIS 157 139 139 HIS HIS B . n 
B 1 158 ILE 158 140 140 ILE ILE B . n 
B 1 159 GLN 159 141 141 GLN GLN B . n 
B 1 160 SER 160 142 142 SER SER B . n 
B 1 161 LEU 161 143 143 LEU LEU B . n 
B 1 162 PHE 162 144 144 PHE PHE B . n 
B 1 163 SER 163 145 145 SER SER B . n 
B 1 164 PHE 164 146 146 PHE PHE B . n 
B 1 165 ILE 165 147 147 ILE ILE B . n 
B 1 166 THR 166 148 148 THR THR B . n 
B 1 167 GLY 167 149 149 GLY GLY B . n 
B 1 168 THR 168 150 150 THR THR B . n 
B 1 169 LYS 169 151 151 LYS LYS B . n 
B 1 170 LEU 170 152 152 LEU LEU B . n 
B 1 171 ASP 171 153 153 ASP ASP B . n 
B 1 172 SER 172 154 154 SER SER B . n 
B 1 173 SER 173 155 155 SER SER B . n 
B 1 174 GLY 174 156 156 GLY GLY B . n 
B 1 175 VAL 175 157 157 VAL VAL B . n 
B 1 176 ALA 176 158 158 ALA ALA B . n 
B 1 177 PHE 177 159 159 PHE PHE B . n 
B 1 178 ALA 178 160 160 ALA ALA B . n 
B 1 179 VAL 179 161 161 VAL VAL B . n 
B 1 180 VAL 180 162 162 VAL VAL B . n 
B 1 181 GLY 181 163 163 GLY GLY B . n 
B 1 182 ALA 182 164 164 ALA ALA B . n 
B 1 183 CYS 183 165 165 CYS CYS B . n 
B 1 184 GLN 184 166 166 GLN GLN B . n 
B 1 185 ALA 185 167 167 ALA ALA B . n 
B 1 186 LEU 186 168 168 LEU LEU B . n 
B 1 187 GLY 187 169 169 GLY GLY B . n 
B 1 188 LEU 188 170 170 LEU LEU B . n 
B 1 189 ARG 189 171 171 ARG ARG B . n 
B 1 190 ASP 190 172 172 ASP ASP B . n 
B 1 191 VAL 191 173 173 VAL VAL B . n 
B 1 192 HIS 192 174 174 HIS HIS B . n 
B 1 193 LEU 193 175 175 LEU LEU B . n 
B 1 194 ALA 194 176 176 ALA ALA B . n 
B 1 195 LEU 195 177 177 LEU LEU B . n 
B 1 196 SER 196 178 178 SER SER B . n 
B 1 197 GLU 197 179 179 GLU GLU B . n 
B 1 198 ASP 198 180 180 ASP ASP B . n 
B 1 199 HIS 199 181 181 HIS HIS B . n 
B 1 200 ALA 200 182 182 ALA ALA B . n 
B 1 201 TRP 201 183 183 TRP TRP B . n 
B 1 202 VAL 202 184 184 VAL VAL B . n 
B 1 203 VAL 203 185 185 VAL VAL B . n 
B 1 204 PHE 204 186 186 PHE PHE B . n 
B 1 205 GLY 205 187 187 GLY GLY B . n 
B 1 206 PRO 206 188 188 PRO PRO B . n 
B 1 207 ASN 207 189 189 ASN ASN B . n 
B 1 208 GLY 208 190 190 GLY GLY B . n 
B 1 209 GLU 209 191 191 GLU GLU B . n 
B 1 210 GLN 210 192 192 GLN GLN B . n 
B 1 211 THR 211 193 193 THR THR B . n 
B 1 212 ALA 212 194 194 ALA ALA B . n 
B 1 213 GLU 213 195 195 GLU GLU B . n 
B 1 214 VAL 214 196 196 VAL VAL B . n 
B 1 215 THR 215 197 197 THR THR B . n 
B 1 216 TRP 216 198 198 TRP TRP B . n 
B 1 217 HIS 217 199 199 HIS HIS B . n 
B 1 218 GLY 218 200 200 GLY GLY B . n 
B 1 219 LYS 219 201 201 LYS LYS B . n 
B 1 220 GLY 220 202 202 GLY GLY B . n 
B 1 221 ASN 221 203 203 ASN ASN B . n 
B 1 222 GLU 222 204 204 GLU GLU B . n 
B 1 223 ASP 223 205 205 ASP ASP B . n 
B 1 224 ARG 224 206 206 ARG ARG B . n 
B 1 225 ARG 225 207 207 ARG ARG B . n 
B 1 226 GLY 226 208 208 GLY GLY B . n 
B 1 227 GLN 227 209 209 GLN GLN B . n 
B 1 228 THR 228 210 210 THR THR B . n 
B 1 229 VAL 229 211 211 VAL VAL B . n 
B 1 230 ASN 230 212 212 ASN ASN B . n 
B 1 231 ALA 231 213 213 ALA ALA B . n 
B 1 232 GLY 232 214 214 GLY GLY B . n 
B 1 233 VAL 233 215 215 VAL VAL B . n 
B 1 234 ALA 234 216 216 ALA ALA B . n 
B 1 235 GLU 235 217 217 GLU GLU B . n 
B 1 236 ARG 236 218 218 ARG ARG B . n 
B 1 237 SER 237 219 219 SER SER B . n 
B 1 238 TRP 238 220 220 TRP TRP B . n 
B 1 239 LEU 239 221 221 LEU LEU B . n 
B 1 240 TYR 240 222 222 TYR TYR B . n 
B 1 241 LEU 241 223 223 LEU LEU B . n 
B 1 242 LYS 242 224 224 LYS LYS B . n 
B 1 243 GLY 243 225 225 GLY GLY B . n 
B 1 244 SER 244 226 226 SER SER B . n 
B 1 245 TYR 245 227 227 TYR TYR B . n 
B 1 246 MET 246 228 228 MET MET B . n 
B 1 247 ARG 247 229 229 ARG ARG B . n 
B 1 248 CYS 248 230 230 CYS CYS B . n 
B 1 249 ASP 249 231 231 ASP ASP B . n 
B 1 250 ARG 250 232 232 ARG ARG B . n 
B 1 251 LYS 251 233 233 LYS LYS B . n 
B 1 252 MET 252 234 234 MET MET B . n 
B 1 253 GLU 253 235 235 GLU GLU B . n 
B 1 254 VAL 254 236 236 VAL VAL B . n 
B 1 255 ALA 255 237 237 ALA ALA B . n 
B 1 256 PHE 256 238 238 PHE PHE B . n 
B 1 257 MET 257 239 239 MET MET B . n 
B 1 258 VAL 258 240 240 VAL VAL B . n 
B 1 259 CYS 259 241 241 CYS CYS B . n 
B 1 260 ALA 260 242 242 ALA ALA B . n 
B 1 261 ILE 261 243 243 ILE ILE B . n 
B 1 262 ASN 262 244 244 ASN ASN B . n 
B 1 263 PRO 263 245 245 PRO PRO B . n 
B 1 264 SER 264 246 246 SER SER B . n 
B 1 265 ILE 265 247 247 ILE ILE B . n 
B 1 266 ASP 266 248 248 ASP ASP B . n 
B 1 267 LEU 267 249 249 LEU LEU B . n 
B 1 268 HIS 268 250 250 HIS HIS B . n 
B 1 269 THR 269 251 251 THR THR B . n 
B 1 270 ASP 270 252 252 ASP ASP B . n 
B 1 271 SER 271 253 253 SER SER B . n 
B 1 272 LEU 272 254 254 LEU LEU B . n 
B 1 273 GLU 273 255 255 GLU GLU B . n 
B 1 274 LEU 274 256 256 LEU LEU B . n 
B 1 275 LEU 275 257 257 LEU LEU B . n 
B 1 276 GLN 276 258 258 GLN GLN B . n 
B 1 277 LEU 277 259 259 LEU LEU B . n 
B 1 278 GLN 278 260 260 GLN GLN B . n 
B 1 279 GLN 279 261 261 GLN GLN B . n 
B 1 280 LYS 280 262 262 LYS LYS B . n 
B 1 281 LEU 281 263 263 LEU LEU B . n 
B 1 282 LEU 282 264 264 LEU LEU B . n 
B 1 283 TRP 283 265 265 TRP TRP B . n 
B 1 284 LEU 284 266 266 LEU LEU B . n 
B 1 285 LEU 285 267 267 LEU LEU B . n 
B 1 286 TYR 286 268 268 TYR TYR B . n 
B 1 287 ASP 287 269 269 ASP ASP B . n 
B 1 288 LEU 288 270 270 LEU LEU B . n 
B 1 289 GLY 289 271 271 GLY GLY B . n 
B 1 290 HIS 290 272 272 HIS HIS B . n 
B 1 291 LEU 291 273 273 LEU LEU B . n 
B 1 292 GLU 292 274 274 GLU GLU B . n 
B 1 293 ARG 293 275 275 ARG ARG B . n 
B 1 294 TYR 294 276 276 TYR TYR B . n 
B 1 295 PRO 295 277 277 PRO PRO B . n 
B 1 296 MET 296 278 278 MET MET B . n 
B 1 297 ALA 297 279 279 ALA ALA B . n 
B 1 298 LEU 298 280 280 LEU LEU B . n 
B 1 299 GLY 299 281 281 GLY GLY B . n 
B 1 300 ASN 300 282 282 ASN ASN B . n 
B 1 301 LEU 301 283 283 LEU LEU B . n 
B 1 302 ALA 302 284 284 ALA ALA B . n 
B 1 303 ASP 303 285 285 ASP ASP B . n 
B 1 304 LEU 304 286 286 LEU LEU B . n 
B 1 305 GLU 305 287 287 GLU GLU B . n 
B 1 306 GLU 306 288 288 GLU GLU B . n 
B 1 307 LEU 307 289 289 LEU LEU B . n 
B 1 308 GLU 308 290 290 GLU GLU B . n 
B 1 309 PRO 309 291 291 PRO PRO B . n 
B 1 310 THR 310 292 292 THR THR B . n 
B 1 311 PRO 311 293 293 PRO PRO B . n 
B 1 312 GLY 312 294 294 GLY GLY B . n 
B 1 313 ARG 313 295 295 ARG ARG B . n 
B 1 314 PRO 314 296 296 PRO PRO B . n 
B 1 315 ASP 315 297 297 ASP ASP B . n 
B 1 316 PRO 316 298 298 PRO PRO B . n 
B 1 317 LEU 317 299 299 LEU LEU B . n 
B 1 318 THR 318 300 300 THR THR B . n 
B 1 319 LEU 319 301 301 LEU LEU B . n 
B 1 320 TYR 320 302 302 TYR TYR B . n 
B 1 321 HIS 321 303 303 HIS HIS B . n 
B 1 322 LYS 322 304 304 LYS LYS B . n 
B 1 323 GLY 323 305 305 GLY GLY B . n 
B 1 324 ILE 324 306 306 ILE ILE B . n 
B 1 325 ALA 325 307 307 ALA ALA B . n 
B 1 326 SER 326 308 308 SER SER B . n 
B 1 327 ALA 327 309 309 ALA ALA B . n 
B 1 328 LYS 328 310 310 LYS LYS B . n 
B 1 329 THR 329 311 311 THR THR B . n 
B 1 330 TYR 330 312 312 TYR TYR B . n 
B 1 331 TYR 331 313 313 TYR TYR B . n 
B 1 332 ARG 332 314 314 ARG ARG B . n 
B 1 333 ASP 333 315 315 ASP ASP B . n 
B 1 334 GLU 334 316 316 GLU GLU B . n 
B 1 335 HIS 335 317 317 HIS HIS B . n 
B 1 336 ILE 336 318 318 ILE ILE B . n 
B 1 337 TYR 337 319 319 TYR TYR B . n 
B 1 338 PRO 338 320 320 PRO PRO B . n 
B 1 339 TYR 339 321 321 TYR TYR B . n 
B 1 340 MET 340 322 322 MET MET B . n 
B 1 341 TYR 341 323 323 TYR TYR B . n 
B 1 342 LEU 342 324 324 LEU LEU B . n 
B 1 343 ALA 343 325 325 ALA ALA B . n 
B 1 344 GLY 344 326 326 GLY GLY B . n 
B 1 345 TYR 345 327 327 TYR TYR B . n 
B 1 346 HIS 346 328 328 HIS HIS B . n 
B 1 347 CYS 347 329 329 CYS CYS B . n 
B 1 348 ARG 348 330 330 ARG ARG B . n 
B 1 349 ASN 349 331 331 ASN ASN B . n 
B 1 350 ARG 350 332 332 ARG ARG B . n 
B 1 351 ASN 351 333 333 ASN ASN B . n 
B 1 352 VAL 352 334 334 VAL VAL B . n 
B 1 353 ARG 353 335 335 ARG ARG B . n 
B 1 354 GLU 354 336 336 GLU GLU B . n 
B 1 355 ALA 355 337 337 ALA ALA B . n 
B 1 356 LEU 356 338 338 LEU LEU B . n 
B 1 357 GLN 357 339 339 GLN GLN B . n 
B 1 358 ALA 358 340 340 ALA ALA B . n 
B 1 359 TRP 359 341 341 TRP TRP B . n 
B 1 360 ALA 360 342 342 ALA ALA B . n 
B 1 361 ASP 361 343 343 ASP ASP B . n 
B 1 362 THR 362 344 344 THR THR B . n 
B 1 363 ALA 363 345 345 ALA ALA B . n 
B 1 364 THR 364 346 346 THR THR B . n 
B 1 365 VAL 365 347 347 VAL VAL B . n 
B 1 366 ILE 366 348 348 ILE ILE B . n 
B 1 367 GLN 367 349 349 GLN GLN B . n 
B 1 368 ASP 368 350 350 ASP ASP B . n 
B 1 369 TYR 369 351 351 TYR TYR B . n 
B 1 370 ASN 370 352 352 ASN ASN B . n 
B 1 371 TYR 371 353 353 TYR TYR B . n 
B 1 372 CYS 372 354 354 CYS CYS B . n 
B 1 373 ARG 373 355 355 ARG ARG B . n 
B 1 374 GLU 374 356 356 GLU GLU B . n 
B 1 375 ASP 375 357 357 ASP ASP B . n 
B 1 376 GLU 376 358 358 GLU GLU B . n 
B 1 377 GLU 377 359 359 GLU GLU B . n 
B 1 378 ILE 378 360 360 ILE ILE B . n 
B 1 379 TYR 379 361 361 TYR TYR B . n 
B 1 380 LYS 380 362 362 LYS LYS B . n 
B 1 381 GLU 381 363 363 GLU GLU B . n 
B 1 382 PHE 382 364 364 PHE PHE B . n 
B 1 383 PHE 383 365 365 PHE PHE B . n 
B 1 384 GLU 384 366 366 GLU GLU B . n 
B 1 385 VAL 385 367 367 VAL VAL B . n 
B 1 386 ALA 386 368 368 ALA ALA B . n 
B 1 387 ASN 387 369 369 ASN ASN B . n 
B 1 388 ASP 388 370 370 ASP ASP B . n 
B 1 389 VAL 389 371 371 VAL VAL B . n 
B 1 390 ILE 390 372 372 ILE ILE B . n 
B 1 391 PRO 391 373 373 PRO PRO B . n 
B 1 392 ASN 392 374 374 ASN ASN B . n 
B 1 393 LEU 393 375 375 LEU LEU B . n 
B 1 394 LEU 394 376 376 LEU LEU B . n 
B 1 395 LYS 395 377 377 LYS LYS B . n 
B 1 396 GLU 396 378 378 GLU GLU B . n 
B 1 397 ALA 397 379 379 ALA ALA B . n 
B 1 398 ALA 398 380 380 ALA ALA B . n 
B 1 399 SER 399 381 381 SER SER B . n 
B 1 400 LEU 400 382 382 LEU LEU B . n 
B 1 401 LEU 401 383 383 LEU LEU B . n 
B 1 402 GLU 402 384 384 GLU GLU B . n 
B 1 403 ALA 403 385 385 ALA ALA B . n 
B 1 404 GLY 404 386 386 GLY GLY B . n 
B 1 405 GLU 405 387 387 GLU GLU B . n 
B 1 406 GLU 406 388 388 GLU GLU B . n 
B 1 407 ARG 407 389 ?   ?   ?   B . n 
B 1 408 PRO 408 390 ?   ?   ?   B . n 
B 1 409 GLY 409 391 ?   ?   ?   B . n 
B 1 410 GLU 410 392 ?   ?   ?   B . n 
B 1 411 GLN 411 393 ?   ?   ?   B . n 
B 1 412 SER 412 394 ?   ?   ?   B . n 
B 1 413 GLN 413 395 ?   ?   ?   B . n 
B 1 414 GLY 414 396 ?   ?   ?   B . n 
B 1 415 THR 415 397 ?   ?   ?   B . n 
B 1 416 GLN 416 398 ?   ?   ?   B . n 
B 1 417 SER 417 399 ?   ?   ?   B . n 
B 1 418 GLN 418 400 ?   ?   ?   B . n 
B 1 419 GLY 419 401 401 GLY GLY B . n 
B 1 420 SER 420 402 402 SER SER B . n 
B 1 421 ALA 421 403 403 ALA ALA B . n 
B 1 422 LEU 422 404 404 LEU LEU B . n 
B 1 423 GLN 423 405 405 GLN GLN B . n 
B 1 424 ASP 424 406 406 ASP ASP B . n 
B 1 425 PRO 425 407 407 PRO PRO B . n 
B 1 426 GLU 426 408 408 GLU GLU B . n 
B 1 427 CYS 427 409 409 CYS CYS B . n 
B 1 428 PHE 428 410 410 PHE PHE B . n 
B 1 429 ALA 429 411 411 ALA ALA B . n 
B 1 430 HIS 430 412 412 HIS HIS B . n 
B 1 431 LEU 431 413 413 LEU LEU B . n 
B 1 432 LEU 432 414 414 LEU LEU B . n 
B 1 433 ARG 433 415 415 ARG ARG B . n 
B 1 434 PHE 434 416 416 PHE PHE B . n 
B 1 435 TYR 435 417 417 TYR TYR B . n 
B 1 436 ASP 436 418 418 ASP ASP B . n 
B 1 437 GLY 437 419 419 GLY GLY B . n 
B 1 438 ILE 438 420 420 ILE ILE B . n 
B 1 439 CYS 439 421 421 CYS CYS B . n 
B 1 440 LYS 440 422 422 LYS LYS B . n 
B 1 441 TRP 441 423 423 TRP TRP B . n 
B 1 442 GLU 442 424 424 GLU GLU B . n 
B 1 443 GLU 443 425 425 GLU GLU B . n 
B 1 444 GLY 444 426 426 GLY GLY B . n 
B 1 445 SER 445 427 427 SER SER B . n 
B 1 446 PRO 446 428 428 PRO PRO B . n 
B 1 447 THR 447 429 429 THR THR B . n 
B 1 448 PRO 448 430 430 PRO PRO B . n 
B 1 449 VAL 449 431 431 VAL VAL B . n 
B 1 450 LEU 450 432 432 LEU LEU B . n 
B 1 451 HIS 451 433 433 HIS HIS B . n 
B 1 452 VAL 452 434 434 VAL VAL B . n 
B 1 453 GLY 453 435 435 GLY GLY B . n 
B 1 454 TRP 454 436 436 TRP TRP B . n 
B 1 455 ALA 455 437 437 ALA ALA B . n 
B 1 456 THR 456 438 438 THR THR B . n 
B 1 457 PHE 457 439 439 PHE PHE B . n 
B 1 458 LEU 458 440 440 LEU LEU B . n 
B 1 459 VAL 459 441 441 VAL VAL B . n 
B 1 460 GLN 460 442 442 GLN GLN B . n 
B 1 461 SER 461 443 443 SER SER B . n 
B 1 462 LEU 462 444 444 LEU LEU B . n 
B 1 463 GLY 463 445 445 GLY GLY B . n 
B 1 464 ARG 464 446 446 ARG ARG B . n 
B 1 465 PHE 465 447 447 PHE PHE B . n 
B 1 466 GLU 466 448 448 GLU GLU B . n 
B 1 467 GLY 467 449 449 GLY GLY B . n 
B 1 468 GLN 468 450 450 GLN GLN B . n 
B 1 469 VAL 469 451 451 VAL VAL B . n 
B 1 470 ARG 470 452 452 ARG ARG B . n 
B 1 471 GLN 471 453 453 GLN GLN B . n 
B 1 472 LYS 472 454 454 LYS LYS B . n 
B 1 473 VAL 473 455 455 VAL VAL B . n 
B 1 474 ARG 474 456 456 ARG ARG B . n 
B 1 475 ILE 475 457 457 ILE ILE B . n 
B 1 476 THR 476 552 552 THR THR B . n 
B 1 477 PHE 477 553 553 PHE PHE B . n 
B 1 478 GLN 478 554 554 GLN GLN B . n 
B 1 479 SER 479 555 555 SER SER B . n 
B 1 480 GLU 480 556 556 GLU GLU B . n 
B 1 481 LYS 481 557 557 LYS LYS B . n 
B 1 482 MET 482 558 558 MET MET B . n 
B 1 483 LYS 483 559 559 LYS LYS B . n 
B 1 484 GLY 484 560 560 GLY GLY B . n 
B 1 485 MET 485 561 561 MET MET B . n 
B 1 486 LYS 486 562 562 LYS LYS B . n 
B 1 487 GLU 487 563 563 GLU GLU B . n 
B 1 488 LEU 488 564 564 LEU LEU B . n 
B 1 489 LEU 489 565 565 LEU LEU B . n 
B 1 490 VAL 490 566 566 VAL VAL B . n 
B 1 491 ALA 491 567 567 ALA ALA B . n 
B 1 492 THR 492 568 568 THR THR B . n 
B 1 493 LYS 493 569 569 LYS LYS B . n 
B 1 494 ILE 494 570 570 ILE ILE B . n 
B 1 495 ASN 495 571 571 ASN ASN B . n 
B 1 496 SER 496 572 572 SER SER B . n 
B 1 497 SER 497 573 573 SER SER B . n 
B 1 498 ALA 498 574 574 ALA ALA B . n 
B 1 499 ILE 499 575 575 ILE ILE B . n 
B 1 500 LYS 500 576 576 LYS LYS B . n 
B 1 501 LEU 501 577 577 LEU LEU B . n 
B 1 502 GLN 502 578 578 GLN GLN B . n 
B 1 503 LEU 503 579 579 LEU LEU B . n 
B 1 504 THR 504 580 580 THR THR B . n 
B 1 505 ALA 505 581 581 ALA ALA B . n 
B 1 506 GLN 506 582 582 GLN GLN B . n 
B 1 507 SER 507 583 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1AVF 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1AVF 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 A1AVF 1   901  901  A1AVF SM1 A . 
D 3 K     1   902  2    K     K   A . 
E 4 EPE   1   601  601  EPE   EPE B . 
F 5 SO4   1   602  602  SO4   SO4 B . 
G 2 A1AVF 1   603  901  A1AVF SM1 B . 
H 3 K     1   604  1    K     K   B . 
I 6 HOH   1   1001 469  HOH   HOH A . 
I 6 HOH   2   1002 515  HOH   HOH A . 
I 6 HOH   3   1003 476  HOH   HOH A . 
I 6 HOH   4   1004 250  HOH   HOH A . 
I 6 HOH   5   1005 260  HOH   HOH A . 
I 6 HOH   6   1006 498  HOH   HOH A . 
I 6 HOH   7   1007 651  HOH   HOH A . 
I 6 HOH   8   1008 820  HOH   HOH A . 
I 6 HOH   9   1009 648  HOH   HOH A . 
I 6 HOH   10  1010 373  HOH   HOH A . 
I 6 HOH   11  1011 183  HOH   HOH A . 
I 6 HOH   12  1012 278  HOH   HOH A . 
I 6 HOH   13  1013 161  HOH   HOH A . 
I 6 HOH   14  1014 745  HOH   HOH A . 
I 6 HOH   15  1015 789  HOH   HOH A . 
I 6 HOH   16  1016 319  HOH   HOH A . 
I 6 HOH   17  1017 348  HOH   HOH A . 
I 6 HOH   18  1018 631  HOH   HOH A . 
I 6 HOH   19  1019 87   HOH   HOH A . 
I 6 HOH   20  1020 268  HOH   HOH A . 
I 6 HOH   21  1021 11   HOH   HOH A . 
I 6 HOH   22  1022 327  HOH   HOH A . 
I 6 HOH   23  1023 642  HOH   HOH A . 
I 6 HOH   24  1024 1007 HOH   HOH A . 
I 6 HOH   25  1025 212  HOH   HOH A . 
I 6 HOH   26  1026 152  HOH   HOH A . 
I 6 HOH   27  1027 235  HOH   HOH A . 
I 6 HOH   28  1028 112  HOH   HOH A . 
I 6 HOH   29  1029 529  HOH   HOH A . 
I 6 HOH   30  1030 694  HOH   HOH A . 
I 6 HOH   31  1031 376  HOH   HOH A . 
I 6 HOH   32  1032 25   HOH   HOH A . 
I 6 HOH   33  1033 622  HOH   HOH A . 
I 6 HOH   34  1034 57   HOH   HOH A . 
I 6 HOH   35  1035 257  HOH   HOH A . 
I 6 HOH   36  1036 615  HOH   HOH A . 
I 6 HOH   37  1037 3    HOH   HOH A . 
I 6 HOH   38  1038 221  HOH   HOH A . 
I 6 HOH   39  1039 53   HOH   HOH A . 
I 6 HOH   40  1040 104  HOH   HOH A . 
I 6 HOH   41  1041 833  HOH   HOH A . 
I 6 HOH   42  1042 812  HOH   HOH A . 
I 6 HOH   43  1043 274  HOH   HOH A . 
I 6 HOH   44  1044 78   HOH   HOH A . 
I 6 HOH   45  1045 7    HOH   HOH A . 
I 6 HOH   46  1046 361  HOH   HOH A . 
I 6 HOH   47  1047 291  HOH   HOH A . 
I 6 HOH   48  1048 176  HOH   HOH A . 
I 6 HOH   49  1049 360  HOH   HOH A . 
I 6 HOH   50  1050 423  HOH   HOH A . 
I 6 HOH   51  1051 454  HOH   HOH A . 
I 6 HOH   52  1052 446  HOH   HOH A . 
I 6 HOH   53  1053 470  HOH   HOH A . 
I 6 HOH   54  1054 608  HOH   HOH A . 
I 6 HOH   55  1055 363  HOH   HOH A . 
I 6 HOH   56  1056 69   HOH   HOH A . 
I 6 HOH   57  1057 217  HOH   HOH A . 
I 6 HOH   58  1058 31   HOH   HOH A . 
I 6 HOH   59  1059 220  HOH   HOH A . 
I 6 HOH   60  1060 81   HOH   HOH A . 
I 6 HOH   61  1061 643  HOH   HOH A . 
I 6 HOH   62  1062 139  HOH   HOH A . 
I 6 HOH   63  1063 166  HOH   HOH A . 
I 6 HOH   64  1064 218  HOH   HOH A . 
I 6 HOH   65  1065 75   HOH   HOH A . 
I 6 HOH   66  1066 391  HOH   HOH A . 
I 6 HOH   67  1067 115  HOH   HOH A . 
I 6 HOH   68  1068 736  HOH   HOH A . 
I 6 HOH   69  1069 661  HOH   HOH A . 
I 6 HOH   70  1070 764  HOH   HOH A . 
I 6 HOH   71  1071 141  HOH   HOH A . 
I 6 HOH   72  1072 49   HOH   HOH A . 
I 6 HOH   73  1073 77   HOH   HOH A . 
I 6 HOH   74  1074 262  HOH   HOH A . 
I 6 HOH   75  1075 29   HOH   HOH A . 
I 6 HOH   76  1076 117  HOH   HOH A . 
I 6 HOH   77  1077 223  HOH   HOH A . 
I 6 HOH   78  1078 58   HOH   HOH A . 
I 6 HOH   79  1079 30   HOH   HOH A . 
I 6 HOH   80  1080 395  HOH   HOH A . 
I 6 HOH   81  1081 190  HOH   HOH A . 
I 6 HOH   82  1082 163  HOH   HOH A . 
I 6 HOH   83  1083 647  HOH   HOH A . 
I 6 HOH   84  1084 827  HOH   HOH A . 
I 6 HOH   85  1085 626  HOH   HOH A . 
I 6 HOH   86  1086 120  HOH   HOH A . 
I 6 HOH   87  1087 375  HOH   HOH A . 
I 6 HOH   88  1088 132  HOH   HOH A . 
I 6 HOH   89  1089 145  HOH   HOH A . 
I 6 HOH   90  1090 449  HOH   HOH A . 
I 6 HOH   91  1091 214  HOH   HOH A . 
I 6 HOH   92  1092 40   HOH   HOH A . 
I 6 HOH   93  1093 149  HOH   HOH A . 
I 6 HOH   94  1094 666  HOH   HOH A . 
I 6 HOH   95  1095 308  HOH   HOH A . 
I 6 HOH   96  1096 353  HOH   HOH A . 
I 6 HOH   97  1097 28   HOH   HOH A . 
I 6 HOH   98  1098 21   HOH   HOH A . 
I 6 HOH   99  1099 283  HOH   HOH A . 
I 6 HOH   100 1100 817  HOH   HOH A . 
I 6 HOH   101 1101 547  HOH   HOH A . 
I 6 HOH   102 1102 198  HOH   HOH A . 
I 6 HOH   103 1103 251  HOH   HOH A . 
I 6 HOH   104 1104 47   HOH   HOH A . 
I 6 HOH   105 1105 15   HOH   HOH A . 
I 6 HOH   106 1106 171  HOH   HOH A . 
I 6 HOH   107 1107 314  HOH   HOH A . 
I 6 HOH   108 1108 148  HOH   HOH A . 
I 6 HOH   109 1109 386  HOH   HOH A . 
I 6 HOH   110 1110 230  HOH   HOH A . 
I 6 HOH   111 1111 545  HOH   HOH A . 
I 6 HOH   112 1112 150  HOH   HOH A . 
I 6 HOH   113 1113 27   HOH   HOH A . 
I 6 HOH   114 1114 306  HOH   HOH A . 
I 6 HOH   115 1115 16   HOH   HOH A . 
I 6 HOH   116 1116 136  HOH   HOH A . 
I 6 HOH   117 1117 394  HOH   HOH A . 
I 6 HOH   118 1118 164  HOH   HOH A . 
I 6 HOH   119 1119 109  HOH   HOH A . 
I 6 HOH   120 1120 358  HOH   HOH A . 
I 6 HOH   121 1121 828  HOH   HOH A . 
I 6 HOH   122 1122 362  HOH   HOH A . 
I 6 HOH   123 1123 215  HOH   HOH A . 
I 6 HOH   124 1124 126  HOH   HOH A . 
I 6 HOH   125 1125 204  HOH   HOH A . 
I 6 HOH   126 1126 591  HOH   HOH A . 
I 6 HOH   127 1127 309  HOH   HOH A . 
I 6 HOH   128 1128 24   HOH   HOH A . 
I 6 HOH   129 1129 768  HOH   HOH A . 
I 6 HOH   130 1130 859  HOH   HOH A . 
I 6 HOH   131 1131 66   HOH   HOH A . 
I 6 HOH   132 1132 349  HOH   HOH A . 
I 6 HOH   133 1133 270  HOH   HOH A . 
I 6 HOH   134 1134 245  HOH   HOH A . 
I 6 HOH   135 1135 487  HOH   HOH A . 
I 6 HOH   136 1136 95   HOH   HOH A . 
I 6 HOH   137 1137 926  HOH   HOH A . 
I 6 HOH   138 1138 207  HOH   HOH A . 
I 6 HOH   139 1139 669  HOH   HOH A . 
I 6 HOH   140 1140 473  HOH   HOH A . 
I 6 HOH   141 1141 703  HOH   HOH A . 
I 6 HOH   142 1142 238  HOH   HOH A . 
I 6 HOH   143 1143 650  HOH   HOH A . 
I 6 HOH   144 1144 504  HOH   HOH A . 
I 6 HOH   145 1145 722  HOH   HOH A . 
I 6 HOH   146 1146 96   HOH   HOH A . 
I 6 HOH   147 1147 778  HOH   HOH A . 
I 6 HOH   148 1148 425  HOH   HOH A . 
I 6 HOH   149 1149 255  HOH   HOH A . 
I 6 HOH   150 1150 691  HOH   HOH A . 
I 6 HOH   151 1151 83   HOH   HOH A . 
I 6 HOH   152 1152 119  HOH   HOH A . 
I 6 HOH   153 1153 79   HOH   HOH A . 
I 6 HOH   154 1154 107  HOH   HOH A . 
I 6 HOH   155 1155 197  HOH   HOH A . 
I 6 HOH   156 1156 52   HOH   HOH A . 
I 6 HOH   157 1157 186  HOH   HOH A . 
I 6 HOH   158 1158 384  HOH   HOH A . 
I 6 HOH   159 1159 404  HOH   HOH A . 
I 6 HOH   160 1160 43   HOH   HOH A . 
I 6 HOH   161 1161 113  HOH   HOH A . 
I 6 HOH   162 1162 277  HOH   HOH A . 
I 6 HOH   163 1163 140  HOH   HOH A . 
I 6 HOH   164 1164 294  HOH   HOH A . 
I 6 HOH   165 1165 516  HOH   HOH A . 
I 6 HOH   166 1166 843  HOH   HOH A . 
I 6 HOH   167 1167 80   HOH   HOH A . 
I 6 HOH   168 1168 86   HOH   HOH A . 
I 6 HOH   169 1169 500  HOH   HOH A . 
I 6 HOH   170 1170 494  HOH   HOH A . 
I 6 HOH   171 1171 974  HOH   HOH A . 
I 6 HOH   172 1172 483  HOH   HOH A . 
I 6 HOH   173 1173 546  HOH   HOH A . 
I 6 HOH   174 1174 174  HOH   HOH A . 
I 6 HOH   175 1175 263  HOH   HOH A . 
I 6 HOH   176 1176 118  HOH   HOH A . 
I 6 HOH   177 1177 598  HOH   HOH A . 
I 6 HOH   178 1178 23   HOH   HOH A . 
I 6 HOH   179 1179 352  HOH   HOH A . 
I 6 HOH   180 1180 804  HOH   HOH A . 
I 6 HOH   181 1181 466  HOH   HOH A . 
I 6 HOH   182 1182 312  HOH   HOH A . 
I 6 HOH   183 1183 332  HOH   HOH A . 
I 6 HOH   184 1184 225  HOH   HOH A . 
I 6 HOH   185 1185 719  HOH   HOH A . 
I 6 HOH   186 1186 92   HOH   HOH A . 
I 6 HOH   187 1187 281  HOH   HOH A . 
I 6 HOH   188 1188 313  HOH   HOH A . 
I 6 HOH   189 1189 787  HOH   HOH A . 
I 6 HOH   190 1190 410  HOH   HOH A . 
I 6 HOH   191 1191 370  HOH   HOH A . 
I 6 HOH   192 1192 94   HOH   HOH A . 
I 6 HOH   193 1193 170  HOH   HOH A . 
I 6 HOH   194 1194 459  HOH   HOH A . 
I 6 HOH   195 1195 525  HOH   HOH A . 
I 6 HOH   196 1196 180  HOH   HOH A . 
I 6 HOH   197 1197 46   HOH   HOH A . 
I 6 HOH   198 1198 728  HOH   HOH A . 
I 6 HOH   199 1199 667  HOH   HOH A . 
I 6 HOH   200 1200 63   HOH   HOH A . 
I 6 HOH   201 1201 412  HOH   HOH A . 
I 6 HOH   202 1202 414  HOH   HOH A . 
I 6 HOH   203 1203 116  HOH   HOH A . 
I 6 HOH   204 1204 710  HOH   HOH A . 
I 6 HOH   205 1205 124  HOH   HOH A . 
I 6 HOH   206 1206 298  HOH   HOH A . 
I 6 HOH   207 1207 103  HOH   HOH A . 
I 6 HOH   208 1208 338  HOH   HOH A . 
I 6 HOH   209 1209 884  HOH   HOH A . 
I 6 HOH   210 1210 605  HOH   HOH A . 
I 6 HOH   211 1211 56   HOH   HOH A . 
I 6 HOH   212 1212 287  HOH   HOH A . 
I 6 HOH   213 1213 472  HOH   HOH A . 
I 6 HOH   214 1214 137  HOH   HOH A . 
I 6 HOH   215 1215 227  HOH   HOH A . 
I 6 HOH   216 1216 184  HOH   HOH A . 
I 6 HOH   217 1217 321  HOH   HOH A . 
I 6 HOH   218 1218 805  HOH   HOH A . 
I 6 HOH   219 1219 173  HOH   HOH A . 
I 6 HOH   220 1220 239  HOH   HOH A . 
I 6 HOH   221 1221 200  HOH   HOH A . 
I 6 HOH   222 1222 625  HOH   HOH A . 
I 6 HOH   223 1223 511  HOH   HOH A . 
I 6 HOH   224 1224 442  HOH   HOH A . 
I 6 HOH   225 1225 570  HOH   HOH A . 
I 6 HOH   226 1226 196  HOH   HOH A . 
I 6 HOH   227 1227 151  HOH   HOH A . 
I 6 HOH   228 1228 434  HOH   HOH A . 
I 6 HOH   229 1229 544  HOH   HOH A . 
I 6 HOH   230 1230 1009 HOH   HOH A . 
I 6 HOH   231 1231 909  HOH   HOH A . 
I 6 HOH   232 1232 385  HOH   HOH A . 
I 6 HOH   233 1233 877  HOH   HOH A . 
I 6 HOH   234 1234 623  HOH   HOH A . 
I 6 HOH   235 1235 241  HOH   HOH A . 
I 6 HOH   236 1236 374  HOH   HOH A . 
I 6 HOH   237 1237 489  HOH   HOH A . 
I 6 HOH   238 1238 783  HOH   HOH A . 
I 6 HOH   239 1239 329  HOH   HOH A . 
I 6 HOH   240 1240 685  HOH   HOH A . 
I 6 HOH   241 1241 383  HOH   HOH A . 
I 6 HOH   242 1242 405  HOH   HOH A . 
I 6 HOH   243 1243 583  HOH   HOH A . 
I 6 HOH   244 1244 61   HOH   HOH A . 
I 6 HOH   245 1245 311  HOH   HOH A . 
I 6 HOH   246 1246 534  HOH   HOH A . 
I 6 HOH   247 1247 415  HOH   HOH A . 
I 6 HOH   248 1248 436  HOH   HOH A . 
I 6 HOH   249 1249 430  HOH   HOH A . 
I 6 HOH   250 1250 646  HOH   HOH A . 
I 6 HOH   251 1251 689  HOH   HOH A . 
I 6 HOH   252 1252 811  HOH   HOH A . 
I 6 HOH   253 1253 300  HOH   HOH A . 
I 6 HOH   254 1254 586  HOH   HOH A . 
I 6 HOH   255 1255 392  HOH   HOH A . 
I 6 HOH   256 1256 998  HOH   HOH A . 
I 6 HOH   257 1257 108  HOH   HOH A . 
I 6 HOH   258 1258 304  HOH   HOH A . 
I 6 HOH   259 1259 823  HOH   HOH A . 
I 6 HOH   260 1260 333  HOH   HOH A . 
I 6 HOH   261 1261 732  HOH   HOH A . 
I 6 HOH   262 1262 135  HOH   HOH A . 
I 6 HOH   263 1263 707  HOH   HOH A . 
I 6 HOH   264 1264 199  HOH   HOH A . 
I 6 HOH   265 1265 675  HOH   HOH A . 
I 6 HOH   266 1266 301  HOH   HOH A . 
I 6 HOH   267 1267 737  HOH   HOH A . 
I 6 HOH   268 1268 156  HOH   HOH A . 
I 6 HOH   269 1269 512  HOH   HOH A . 
I 6 HOH   270 1270 522  HOH   HOH A . 
I 6 HOH   271 1271 191  HOH   HOH A . 
I 6 HOH   272 1272 279  HOH   HOH A . 
I 6 HOH   273 1273 428  HOH   HOH A . 
I 6 HOH   274 1274 634  HOH   HOH A . 
I 6 HOH   275 1275 818  HOH   HOH A . 
I 6 HOH   276 1276 438  HOH   HOH A . 
I 6 HOH   277 1277 788  HOH   HOH A . 
I 6 HOH   278 1278 815  HOH   HOH A . 
I 6 HOH   279 1279 632  HOH   HOH A . 
I 6 HOH   280 1280 246  HOH   HOH A . 
I 6 HOH   281 1281 240  HOH   HOH A . 
I 6 HOH   282 1282 524  HOH   HOH A . 
I 6 HOH   283 1283 379  HOH   HOH A . 
I 6 HOH   284 1284 420  HOH   HOH A . 
I 6 HOH   285 1285 809  HOH   HOH A . 
I 6 HOH   286 1286 303  HOH   HOH A . 
I 6 HOH   287 1287 777  HOH   HOH A . 
I 6 HOH   288 1288 671  HOH   HOH A . 
I 6 HOH   289 1289 760  HOH   HOH A . 
I 6 HOH   290 1290 712  HOH   HOH A . 
I 6 HOH   291 1291 1002 HOH   HOH A . 
I 6 HOH   292 1292 595  HOH   HOH A . 
I 6 HOH   293 1293 1008 HOH   HOH A . 
I 6 HOH   294 1294 831  HOH   HOH A . 
I 6 HOH   295 1295 496  HOH   HOH A . 
I 6 HOH   296 1296 290  HOH   HOH A . 
I 6 HOH   297 1297 267  HOH   HOH A . 
I 6 HOH   298 1298 752  HOH   HOH A . 
I 6 HOH   299 1299 742  HOH   HOH A . 
I 6 HOH   300 1300 531  HOH   HOH A . 
I 6 HOH   301 1301 705  HOH   HOH A . 
I 6 HOH   302 1302 644  HOH   HOH A . 
I 6 HOH   303 1303 633  HOH   HOH A . 
I 6 HOH   304 1304 387  HOH   HOH A . 
I 6 HOH   305 1305 717  HOH   HOH A . 
I 6 HOH   306 1306 649  HOH   HOH A . 
I 6 HOH   307 1307 377  HOH   HOH A . 
I 6 HOH   308 1308 157  HOH   HOH A . 
I 6 HOH   309 1309 264  HOH   HOH A . 
I 6 HOH   310 1310 35   HOH   HOH A . 
I 6 HOH   311 1311 578  HOH   HOH A . 
I 6 HOH   312 1312 996  HOH   HOH A . 
I 6 HOH   313 1313 580  HOH   HOH A . 
I 6 HOH   314 1314 445  HOH   HOH A . 
I 6 HOH   315 1315 406  HOH   HOH A . 
I 6 HOH   316 1316 609  HOH   HOH A . 
I 6 HOH   317 1317 509  HOH   HOH A . 
I 6 HOH   318 1318 474  HOH   HOH A . 
I 6 HOH   319 1319 1000 HOH   HOH A . 
I 6 HOH   320 1320 532  HOH   HOH A . 
I 6 HOH   321 1321 543  HOH   HOH A . 
I 6 HOH   322 1322 621  HOH   HOH A . 
I 6 HOH   323 1323 243  HOH   HOH A . 
I 6 HOH   324 1324 182  HOH   HOH A . 
I 6 HOH   325 1325 177  HOH   HOH A . 
I 6 HOH   326 1326 612  HOH   HOH A . 
I 6 HOH   327 1327 563  HOH   HOH A . 
I 6 HOH   328 1328 571  HOH   HOH A . 
I 6 HOH   329 1329 606  HOH   HOH A . 
I 6 HOH   330 1330 226  HOH   HOH A . 
I 6 HOH   331 1331 590  HOH   HOH A . 
I 6 HOH   332 1332 340  HOH   HOH A . 
I 6 HOH   333 1333 409  HOH   HOH A . 
I 6 HOH   334 1334 272  HOH   HOH A . 
I 6 HOH   335 1335 233  HOH   HOH A . 
I 6 HOH   336 1336 526  HOH   HOH A . 
I 6 HOH   337 1337 354  HOH   HOH A . 
I 6 HOH   338 1338 593  HOH   HOH A . 
J 6 HOH   1   701  995  HOH   HOH B . 
J 6 HOH   2   702  993  HOH   HOH B . 
J 6 HOH   3   703  579  HOH   HOH B . 
J 6 HOH   4   704  989  HOH   HOH B . 
J 6 HOH   5   705  599  HOH   HOH B . 
J 6 HOH   6   706  286  HOH   HOH B . 
J 6 HOH   7   707  341  HOH   HOH B . 
J 6 HOH   8   708  1006 HOH   HOH B . 
J 6 HOH   9   709  567  HOH   HOH B . 
J 6 HOH   10  710  992  HOH   HOH B . 
J 6 HOH   11  711  36   HOH   HOH B . 
J 6 HOH   12  712  574  HOH   HOH B . 
J 6 HOH   13  713  305  HOH   HOH B . 
J 6 HOH   14  714  829  HOH   HOH B . 
J 6 HOH   15  715  799  HOH   HOH B . 
J 6 HOH   16  716  222  HOH   HOH B . 
J 6 HOH   17  717  637  HOH   HOH B . 
J 6 HOH   18  718  443  HOH   HOH B . 
J 6 HOH   19  719  160  HOH   HOH B . 
J 6 HOH   20  720  372  HOH   HOH B . 
J 6 HOH   21  721  316  HOH   HOH B . 
J 6 HOH   22  722  444  HOH   HOH B . 
J 6 HOH   23  723  242  HOH   HOH B . 
J 6 HOH   24  724  211  HOH   HOH B . 
J 6 HOH   25  725  167  HOH   HOH B . 
J 6 HOH   26  726  825  HOH   HOH B . 
J 6 HOH   27  727  381  HOH   HOH B . 
J 6 HOH   28  728  427  HOH   HOH B . 
J 6 HOH   29  729  296  HOH   HOH B . 
J 6 HOH   30  730  84   HOH   HOH B . 
J 6 HOH   31  731  539  HOH   HOH B . 
J 6 HOH   32  732  266  HOH   HOH B . 
J 6 HOH   33  733  203  HOH   HOH B . 
J 6 HOH   34  734  12   HOH   HOH B . 
J 6 HOH   35  735  894  HOH   HOH B . 
J 6 HOH   36  736  5    HOH   HOH B . 
J 6 HOH   37  737  289  HOH   HOH B . 
J 6 HOH   38  738  32   HOH   HOH B . 
J 6 HOH   39  739  397  HOH   HOH B . 
J 6 HOH   40  740  807  HOH   HOH B . 
J 6 HOH   41  741  411  HOH   HOH B . 
J 6 HOH   42  742  189  HOH   HOH B . 
J 6 HOH   43  743  185  HOH   HOH B . 
J 6 HOH   44  744  68   HOH   HOH B . 
J 6 HOH   45  745  33   HOH   HOH B . 
J 6 HOH   46  746  248  HOH   HOH B . 
J 6 HOH   47  747  343  HOH   HOH B . 
J 6 HOH   48  748  510  HOH   HOH B . 
J 6 HOH   49  749  364  HOH   HOH B . 
J 6 HOH   50  750  71   HOH   HOH B . 
J 6 HOH   51  751  741  HOH   HOH B . 
J 6 HOH   52  752  369  HOH   HOH B . 
J 6 HOH   53  753  70   HOH   HOH B . 
J 6 HOH   54  754  479  HOH   HOH B . 
J 6 HOH   55  755  346  HOH   HOH B . 
J 6 HOH   56  756  100  HOH   HOH B . 
J 6 HOH   57  757  20   HOH   HOH B . 
J 6 HOH   58  758  261  HOH   HOH B . 
J 6 HOH   59  759  122  HOH   HOH B . 
J 6 HOH   60  760  13   HOH   HOH B . 
J 6 HOH   61  761  51   HOH   HOH B . 
J 6 HOH   62  762  841  HOH   HOH B . 
J 6 HOH   63  763  65   HOH   HOH B . 
J 6 HOH   64  764  236  HOH   HOH B . 
J 6 HOH   65  765  746  HOH   HOH B . 
J 6 HOH   66  766  297  HOH   HOH B . 
J 6 HOH   67  767  19   HOH   HOH B . 
J 6 HOH   68  768  102  HOH   HOH B . 
J 6 HOH   69  769  317  HOH   HOH B . 
J 6 HOH   70  770  55   HOH   HOH B . 
J 6 HOH   71  771  1001 HOH   HOH B . 
J 6 HOH   72  772  97   HOH   HOH B . 
J 6 HOH   73  773  175  HOH   HOH B . 
J 6 HOH   74  774  123  HOH   HOH B . 
J 6 HOH   75  775  271  HOH   HOH B . 
J 6 HOH   76  776  85   HOH   HOH B . 
J 6 HOH   77  777  441  HOH   HOH B . 
J 6 HOH   78  778  22   HOH   HOH B . 
J 6 HOH   79  779  614  HOH   HOH B . 
J 6 HOH   80  780  88   HOH   HOH B . 
J 6 HOH   81  781  265  HOH   HOH B . 
J 6 HOH   82  782  127  HOH   HOH B . 
J 6 HOH   83  783  419  HOH   HOH B . 
J 6 HOH   84  784  418  HOH   HOH B . 
J 6 HOH   85  785  638  HOH   HOH B . 
J 6 HOH   86  786  620  HOH   HOH B . 
J 6 HOH   87  787  42   HOH   HOH B . 
J 6 HOH   88  788  628  HOH   HOH B . 
J 6 HOH   89  789  128  HOH   HOH B . 
J 6 HOH   90  790  382  HOH   HOH B . 
J 6 HOH   91  791  48   HOH   HOH B . 
J 6 HOH   92  792  44   HOH   HOH B . 
J 6 HOH   93  793  366  HOH   HOH B . 
J 6 HOH   94  794  460  HOH   HOH B . 
J 6 HOH   95  795  134  HOH   HOH B . 
J 6 HOH   96  796  18   HOH   HOH B . 
J 6 HOH   97  797  400  HOH   HOH B . 
J 6 HOH   98  798  334  HOH   HOH B . 
J 6 HOH   99  799  493  HOH   HOH B . 
J 6 HOH   100 800  202  HOH   HOH B . 
J 6 HOH   101 801  249  HOH   HOH B . 
J 6 HOH   102 802  193  HOH   HOH B . 
J 6 HOH   103 803  848  HOH   HOH B . 
J 6 HOH   104 804  451  HOH   HOH B . 
J 6 HOH   105 805  194  HOH   HOH B . 
J 6 HOH   106 806  670  HOH   HOH B . 
J 6 HOH   107 807  210  HOH   HOH B . 
J 6 HOH   108 808  837  HOH   HOH B . 
J 6 HOH   109 809  528  HOH   HOH B . 
J 6 HOH   110 810  432  HOH   HOH B . 
J 6 HOH   111 811  845  HOH   HOH B . 
J 6 HOH   112 812  276  HOH   HOH B . 
J 6 HOH   113 813  548  HOH   HOH B . 
J 6 HOH   114 814  187  HOH   HOH B . 
J 6 HOH   115 815  302  HOH   HOH B . 
J 6 HOH   116 816  231  HOH   HOH B . 
J 6 HOH   117 817  541  HOH   HOH B . 
J 6 HOH   118 818  538  HOH   HOH B . 
J 6 HOH   119 819  371  HOH   HOH B . 
J 6 HOH   120 820  288  HOH   HOH B . 
J 6 HOH   121 821  146  HOH   HOH B . 
J 6 HOH   122 822  10   HOH   HOH B . 
J 6 HOH   123 823  26   HOH   HOH B . 
J 6 HOH   124 824  206  HOH   HOH B . 
J 6 HOH   125 825  34   HOH   HOH B . 
J 6 HOH   126 826  179  HOH   HOH B . 
J 6 HOH   127 827  331  HOH   HOH B . 
J 6 HOH   128 828  195  HOH   HOH B . 
J 6 HOH   129 829  143  HOH   HOH B . 
J 6 HOH   130 830  17   HOH   HOH B . 
J 6 HOH   131 831  76   HOH   HOH B . 
J 6 HOH   132 832  45   HOH   HOH B . 
J 6 HOH   133 833  106  HOH   HOH B . 
J 6 HOH   134 834  133  HOH   HOH B . 
J 6 HOH   135 835  9    HOH   HOH B . 
J 6 HOH   136 836  465  HOH   HOH B . 
J 6 HOH   137 837  101  HOH   HOH B . 
J 6 HOH   138 838  105  HOH   HOH B . 
J 6 HOH   139 839  129  HOH   HOH B . 
J 6 HOH   140 840  254  HOH   HOH B . 
J 6 HOH   141 841  431  HOH   HOH B . 
J 6 HOH   142 842  60   HOH   HOH B . 
J 6 HOH   143 843  693  HOH   HOH B . 
J 6 HOH   144 844  62   HOH   HOH B . 
J 6 HOH   145 845  527  HOH   HOH B . 
J 6 HOH   146 846  147  HOH   HOH B . 
J 6 HOH   147 847  293  HOH   HOH B . 
J 6 HOH   148 848  73   HOH   HOH B . 
J 6 HOH   149 849  280  HOH   HOH B . 
J 6 HOH   150 850  437  HOH   HOH B . 
J 6 HOH   151 851  506  HOH   HOH B . 
J 6 HOH   152 852  125  HOH   HOH B . 
J 6 HOH   153 853  576  HOH   HOH B . 
J 6 HOH   154 854  318  HOH   HOH B . 
J 6 HOH   155 855  64   HOH   HOH B . 
J 6 HOH   156 856  258  HOH   HOH B . 
J 6 HOH   157 857  114  HOH   HOH B . 
J 6 HOH   158 858  310  HOH   HOH B . 
J 6 HOH   159 859  178  HOH   HOH B . 
J 6 HOH   160 860  786  HOH   HOH B . 
J 6 HOH   161 861  554  HOH   HOH B . 
J 6 HOH   162 862  82   HOH   HOH B . 
J 6 HOH   163 863  339  HOH   HOH B . 
J 6 HOH   164 864  315  HOH   HOH B . 
J 6 HOH   165 865  259  HOH   HOH B . 
J 6 HOH   166 866  98   HOH   HOH B . 
J 6 HOH   167 867  455  HOH   HOH B . 
J 6 HOH   168 868  295  HOH   HOH B . 
J 6 HOH   169 869  433  HOH   HOH B . 
J 6 HOH   170 870  795  HOH   HOH B . 
J 6 HOH   171 871  41   HOH   HOH B . 
J 6 HOH   172 872  4    HOH   HOH B . 
J 6 HOH   173 873  416  HOH   HOH B . 
J 6 HOH   174 874  1004 HOH   HOH B . 
J 6 HOH   175 875  565  HOH   HOH B . 
J 6 HOH   176 876  38   HOH   HOH B . 
J 6 HOH   177 877  378  HOH   HOH B . 
J 6 HOH   178 878  229  HOH   HOH B . 
J 6 HOH   179 879  701  HOH   HOH B . 
J 6 HOH   180 880  640  HOH   HOH B . 
J 6 HOH   181 881  652  HOH   HOH B . 
J 6 HOH   182 882  208  HOH   HOH B . 
J 6 HOH   183 883  67   HOH   HOH B . 
J 6 HOH   184 884  142  HOH   HOH B . 
J 6 HOH   185 885  704  HOH   HOH B . 
J 6 HOH   186 886  228  HOH   HOH B . 
J 6 HOH   187 887  155  HOH   HOH B . 
J 6 HOH   188 888  138  HOH   HOH B . 
J 6 HOH   189 889  589  HOH   HOH B . 
J 6 HOH   190 890  502  HOH   HOH B . 
J 6 HOH   191 891  110  HOH   HOH B . 
J 6 HOH   192 892  216  HOH   HOH B . 
J 6 HOH   193 893  519  HOH   HOH B . 
J 6 HOH   194 894  159  HOH   HOH B . 
J 6 HOH   195 895  407  HOH   HOH B . 
J 6 HOH   196 896  388  HOH   HOH B . 
J 6 HOH   197 897  285  HOH   HOH B . 
J 6 HOH   198 898  181  HOH   HOH B . 
J 6 HOH   199 899  424  HOH   HOH B . 
J 6 HOH   200 900  399  HOH   HOH B . 
J 6 HOH   201 901  91   HOH   HOH B . 
J 6 HOH   202 902  337  HOH   HOH B . 
J 6 HOH   203 903  192  HOH   HOH B . 
J 6 HOH   204 904  37   HOH   HOH B . 
J 6 HOH   205 905  93   HOH   HOH B . 
J 6 HOH   206 906  398  HOH   HOH B . 
J 6 HOH   207 907  72   HOH   HOH B . 
J 6 HOH   208 908  282  HOH   HOH B . 
J 6 HOH   209 909  601  HOH   HOH B . 
J 6 HOH   210 910  421  HOH   HOH B . 
J 6 HOH   211 911  219  HOH   HOH B . 
J 6 HOH   212 912  422  HOH   HOH B . 
J 6 HOH   213 913  89   HOH   HOH B . 
J 6 HOH   214 914  169  HOH   HOH B . 
J 6 HOH   215 915  324  HOH   HOH B . 
J 6 HOH   216 916  213  HOH   HOH B . 
J 6 HOH   217 917  557  HOH   HOH B . 
J 6 HOH   218 918  507  HOH   HOH B . 
J 6 HOH   219 919  581  HOH   HOH B . 
J 6 HOH   220 920  172  HOH   HOH B . 
J 6 HOH   221 921  320  HOH   HOH B . 
J 6 HOH   222 922  679  HOH   HOH B . 
J 6 HOH   223 923  560  HOH   HOH B . 
J 6 HOH   224 924  365  HOH   HOH B . 
J 6 HOH   225 925  639  HOH   HOH B . 
J 6 HOH   226 926  39   HOH   HOH B . 
J 6 HOH   227 927  367  HOH   HOH B . 
J 6 HOH   228 928  234  HOH   HOH B . 
J 6 HOH   229 929  453  HOH   HOH B . 
J 6 HOH   230 930  482  HOH   HOH B . 
J 6 HOH   231 931  50   HOH   HOH B . 
J 6 HOH   232 932  619  HOH   HOH B . 
J 6 HOH   233 933  389  HOH   HOH B . 
J 6 HOH   234 934  158  HOH   HOH B . 
J 6 HOH   235 935  720  HOH   HOH B . 
J 6 HOH   236 936  252  HOH   HOH B . 
J 6 HOH   237 937  761  HOH   HOH B . 
J 6 HOH   238 938  663  HOH   HOH B . 
J 6 HOH   239 939  54   HOH   HOH B . 
J 6 HOH   240 940  2    HOH   HOH B . 
J 6 HOH   241 941  328  HOH   HOH B . 
J 6 HOH   242 942  99   HOH   HOH B . 
J 6 HOH   243 943  882  HOH   HOH B . 
J 6 HOH   244 944  457  HOH   HOH B . 
J 6 HOH   245 945  121  HOH   HOH B . 
J 6 HOH   246 946  188  HOH   HOH B . 
J 6 HOH   247 947  154  HOH   HOH B . 
J 6 HOH   248 948  447  HOH   HOH B . 
J 6 HOH   249 949  616  HOH   HOH B . 
J 6 HOH   250 950  800  HOH   HOH B . 
J 6 HOH   251 951  458  HOH   HOH B . 
J 6 HOH   252 952  292  HOH   HOH B . 
J 6 HOH   253 953  168  HOH   HOH B . 
J 6 HOH   254 954  562  HOH   HOH B . 
J 6 HOH   255 955  90   HOH   HOH B . 
J 6 HOH   256 956  368  HOH   HOH B . 
J 6 HOH   257 957  359  HOH   HOH B . 
J 6 HOH   258 958  396  HOH   HOH B . 
J 6 HOH   259 959  325  HOH   HOH B . 
J 6 HOH   260 960  74   HOH   HOH B . 
J 6 HOH   261 961  559  HOH   HOH B . 
J 6 HOH   262 962  780  HOH   HOH B . 
J 6 HOH   263 963  731  HOH   HOH B . 
J 6 HOH   264 964  131  HOH   HOH B . 
J 6 HOH   265 965  627  HOH   HOH B . 
J 6 HOH   266 966  495  HOH   HOH B . 
J 6 HOH   267 967  604  HOH   HOH B . 
J 6 HOH   268 968  59   HOH   HOH B . 
J 6 HOH   269 969  711  HOH   HOH B . 
J 6 HOH   270 970  335  HOH   HOH B . 
J 6 HOH   271 971  323  HOH   HOH B . 
J 6 HOH   272 972  660  HOH   HOH B . 
J 6 HOH   273 973  706  HOH   HOH B . 
J 6 HOH   274 974  273  HOH   HOH B . 
J 6 HOH   275 975  806  HOH   HOH B . 
J 6 HOH   276 976  130  HOH   HOH B . 
J 6 HOH   277 977  753  HOH   HOH B . 
J 6 HOH   278 978  769  HOH   HOH B . 
J 6 HOH   279 979  810  HOH   HOH B . 
J 6 HOH   280 980  253  HOH   HOH B . 
J 6 HOH   281 981  256  HOH   HOH B . 
J 6 HOH   282 982  530  HOH   HOH B . 
J 6 HOH   283 983  144  HOH   HOH B . 
J 6 HOH   284 984  481  HOH   HOH B . 
J 6 HOH   285 985  439  HOH   HOH B . 
J 6 HOH   286 986  237  HOH   HOH B . 
J 6 HOH   287 987  835  HOH   HOH B . 
J 6 HOH   288 988  987  HOH   HOH B . 
J 6 HOH   289 989  617  HOH   HOH B . 
J 6 HOH   290 990  344  HOH   HOH B . 
J 6 HOH   291 991  682  HOH   HOH B . 
J 6 HOH   292 992  299  HOH   HOH B . 
J 6 HOH   293 993  322  HOH   HOH B . 
J 6 HOH   294 994  999  HOH   HOH B . 
J 6 HOH   295 995  326  HOH   HOH B . 
J 6 HOH   296 996  834  HOH   HOH B . 
J 6 HOH   297 997  577  HOH   HOH B . 
J 6 HOH   298 998  757  HOH   HOH B . 
J 6 HOH   299 999  596  HOH   HOH B . 
J 6 HOH   300 1000 501  HOH   HOH B . 
J 6 HOH   301 1001 672  HOH   HOH B . 
J 6 HOH   302 1002 573  HOH   HOH B . 
J 6 HOH   303 1003 709  HOH   HOH B . 
J 6 HOH   304 1004 355  HOH   HOH B . 
J 6 HOH   305 1005 537  HOH   HOH B . 
J 6 HOH   306 1006 683  HOH   HOH B . 
J 6 HOH   307 1007 755  HOH   HOH B . 
J 6 HOH   308 1008 350  HOH   HOH B . 
J 6 HOH   309 1009 575  HOH   HOH B . 
J 6 HOH   310 1010 205  HOH   HOH B . 
J 6 HOH   311 1011 582  HOH   HOH B . 
J 6 HOH   312 1012 275  HOH   HOH B . 
J 6 HOH   313 1013 553  HOH   HOH B . 
J 6 HOH   314 1014 503  HOH   HOH B . 
J 6 HOH   315 1015 269  HOH   HOH B . 
J 6 HOH   316 1016 345  HOH   HOH B . 
J 6 HOH   317 1017 209  HOH   HOH B . 
J 6 HOH   318 1018 658  HOH   HOH B . 
J 6 HOH   319 1019 771  HOH   HOH B . 
J 6 HOH   320 1020 782  HOH   HOH B . 
J 6 HOH   321 1021 402  HOH   HOH B . 
J 6 HOH   322 1022 611  HOH   HOH B . 
J 6 HOH   323 1023 14   HOH   HOH B . 
J 6 HOH   324 1024 572  HOH   HOH B . 
J 6 HOH   325 1025 584  HOH   HOH B . 
J 6 HOH   326 1026 668  HOH   HOH B . 
J 6 HOH   327 1027 463  HOH   HOH B . 
J 6 HOH   328 1028 588  HOH   HOH B . 
J 6 HOH   329 1029 351  HOH   HOH B . 
J 6 HOH   330 1030 558  HOH   HOH B . 
J 6 HOH   331 1031 162  HOH   HOH B . 
J 6 HOH   332 1032 307  HOH   HOH B . 
J 6 HOH   333 1033 478  HOH   HOH B . 
J 6 HOH   334 1034 165  HOH   HOH B . 
J 6 HOH   335 1035 715  HOH   HOH B . 
J 6 HOH   336 1036 714  HOH   HOH B . 
J 6 HOH   337 1037 740  HOH   HOH B . 
J 6 HOH   338 1038 448  HOH   HOH B . 
J 6 HOH   339 1039 520  HOH   HOH B . 
J 6 HOH   340 1040 653  HOH   HOH B . 
J 6 HOH   341 1041 153  HOH   HOH B . 
J 6 HOH   342 1042 491  HOH   HOH B . 
J 6 HOH   343 1043 790  HOH   HOH B . 
J 6 HOH   344 1044 467  HOH   HOH B . 
J 6 HOH   345 1045 111  HOH   HOH B . 
J 6 HOH   346 1046 781  HOH   HOH B . 
J 6 HOH   347 1047 533  HOH   HOH B . 
J 6 HOH   348 1048 342  HOH   HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ARG 131 ? CG  ? A ARG 149 CG  
2  1 Y 1 A ARG 131 ? CD  ? A ARG 149 CD  
3  1 Y 1 A ARG 131 ? NE  ? A ARG 149 NE  
4  1 Y 1 A ARG 131 ? CZ  ? A ARG 149 CZ  
5  1 Y 1 A ARG 131 ? NH1 ? A ARG 149 NH1 
6  1 Y 1 A ARG 131 ? NH2 ? A ARG 149 NH2 
7  1 Y 1 A HIS 250 ? CG  ? A HIS 268 CG  
8  1 Y 1 A HIS 250 ? ND1 ? A HIS 268 ND1 
9  1 Y 1 A HIS 250 ? CD2 ? A HIS 268 CD2 
10 1 Y 1 A HIS 250 ? CE1 ? A HIS 268 CE1 
11 1 Y 1 A HIS 250 ? NE2 ? A HIS 268 NE2 
12 1 Y 1 B ARG 131 ? CG  ? B ARG 149 CG  
13 1 Y 1 B ARG 131 ? CD  ? B ARG 149 CD  
14 1 Y 1 B ARG 131 ? NE  ? B ARG 149 NE  
15 1 Y 1 B ARG 131 ? CZ  ? B ARG 149 CZ  
16 1 Y 1 B ARG 131 ? NH1 ? B ARG 149 NH1 
17 1 Y 1 B ARG 131 ? NH2 ? B ARG 149 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX      ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? CrysalisPro ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless     ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER      ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9C93 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     56.559 
_cell.length_a_esd                 ? 
_cell.length_b                     87.291 
_cell.length_b_esd                 ? 
_cell.length_c                     194.974 
_cell.length_c_esd                 ? 
_cell.volume                       962604.511 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9C93 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9C93 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.11 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          41.72 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '18% PEG 3350, 0.1M HEPES pH6.9, 0.2M K Thiocyanate, 4% Isopropanol, 1% Tacsimate' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER R 4M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-10-28 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.54 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      'ROTATING ANODE' 
_diffrn_source.target                      ? 
_diffrn_source.type                        'RIGAKU FR-X' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.54 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   ? 
_diffrn_source.pdbx_synchrotron_site       ? 
# 
_reflns.B_iso_Wilson_estimate                          17.68 
_reflns.entry_id                                       9C93 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.85 
_reflns.d_resolution_low                               22.38 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     82556 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          11.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.113 
_reflns.pdbx_Rpim_I_all                                0.046 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.102 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.85 
_reflns_shell.d_res_low                                     1.89 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           1.7 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             14869 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               3.8 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.918 
_reflns_shell.pdbx_Rpim_I_all                               0.449 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.540 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          88.1 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.733 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               21.92 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9C93 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.85 
_refine.ls_d_res_low                             22.38 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     82556 
_refine.ls_number_reflns_R_free                  7767 
_refine.ls_number_reflns_R_work                  147563 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    97.59 
_refine.ls_percent_reflns_R_free                 5.00 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1819 
_refine.ls_R_factor_R_free                       0.2247 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1797 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          0.00 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 22.0450 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.1913 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.85 
_refine_hist.d_res_low                        22.38 
_refine_hist.number_atoms_solvent             686 
_refine_hist.number_atoms_total               8121 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        7341 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         94 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0057  ? 7662  ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.8577  ? 10422 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0457  ? 1144  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0075  ? 1325  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 16.5726 ? 1066  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.85 1.87  . . 208 3956 78.14  . . . . 0.2888 . . . . . . . . . . . 0.3110 
'X-RAY DIFFRACTION' 1.87 1.89  . . 235 4531 89.42  . . . . 0.2718 . . . . . . . . . . . 0.3243 
'X-RAY DIFFRACTION' 1.89 1.92  . . 253 4738 95.18  . . . . 0.2685 . . . . . . . . . . . 0.3256 
'X-RAY DIFFRACTION' 1.92 1.94  . . 260 4874 95.46  . . . . 0.2631 . . . . . . . . . . . 0.3324 
'X-RAY DIFFRACTION' 1.94 1.97  . . 249 4836 95.83  . . . . 0.2555 . . . . . . . . . . . 0.2994 
'X-RAY DIFFRACTION' 1.97 1.99  . . 251 4814 96.60  . . . . 0.2403 . . . . . . . . . . . 0.2772 
'X-RAY DIFFRACTION' 1.99 2.02  . . 260 4948 97.02  . . . . 0.2422 . . . . . . . . . . . 0.3115 
'X-RAY DIFFRACTION' 2.02 2.05  . . 257 4854 97.43  . . . . 0.2233 . . . . . . . . . . . 0.2433 
'X-RAY DIFFRACTION' 2.05 2.08  . . 261 4984 97.58  . . . . 0.2170 . . . . . . . . . . . 0.2701 
'X-RAY DIFFRACTION' 2.08 2.12  . . 256 4878 97.96  . . . . 0.2063 . . . . . . . . . . . 0.2566 
'X-RAY DIFFRACTION' 2.12 2.15  . . 255 4876 98.09  . . . . 0.1984 . . . . . . . . . . . 0.2525 
'X-RAY DIFFRACTION' 2.15 2.19  . . 273 5088 99.44  . . . . 0.1908 . . . . . . . . . . . 0.2438 
'X-RAY DIFFRACTION' 2.19 2.24  . . 268 5007 99.66  . . . . 0.1853 . . . . . . . . . . . 0.2302 
'X-RAY DIFFRACTION' 2.24 2.28  . . 265 5029 99.53  . . . . 0.1804 . . . . . . . . . . . 0.2280 
'X-RAY DIFFRACTION' 2.28 2.33  . . 263 4990 99.56  . . . . 0.1791 . . . . . . . . . . . 0.2437 
'X-RAY DIFFRACTION' 2.33 2.38  . . 269 5033 99.61  . . . . 0.1717 . . . . . . . . . . . 0.2351 
'X-RAY DIFFRACTION' 2.38 2.44  . . 264 4985 99.45  . . . . 0.1789 . . . . . . . . . . . 0.2133 
'X-RAY DIFFRACTION' 2.44 2.51  . . 269 5023 99.34  . . . . 0.1767 . . . . . . . . . . . 0.2259 
'X-RAY DIFFRACTION' 2.51 2.58  . . 266 5013 99.49  . . . . 0.1783 . . . . . . . . . . . 0.2289 
'X-RAY DIFFRACTION' 2.58 2.67  . . 268 5019 99.60  . . . . 0.1792 . . . . . . . . . . . 0.2309 
'X-RAY DIFFRACTION' 2.67 2.76  . . 261 5001 99.58  . . . . 0.1861 . . . . . . . . . . . 0.2407 
'X-RAY DIFFRACTION' 2.76 2.87  . . 260 5029 99.66  . . . . 0.1829 . . . . . . . . . . . 0.2225 
'X-RAY DIFFRACTION' 2.87 3.00  . . 264 5038 99.76  . . . . 0.1713 . . . . . . . . . . . 0.2105 
'X-RAY DIFFRACTION' 3.00 3.16  . . 264 5028 99.83  . . . . 0.1718 . . . . . . . . . . . 0.2280 
'X-RAY DIFFRACTION' 3.16 3.36  . . 266 5046 99.87  . . . . 0.1669 . . . . . . . . . . . 0.1990 
'X-RAY DIFFRACTION' 3.36 3.62  . . 263 5034 100.00 . . . . 0.1510 . . . . . . . . . . . 0.1826 
'X-RAY DIFFRACTION' 3.62 3.98  . . 264 5047 99.98  . . . . 0.1408 . . . . . . . . . . . 0.1663 
'X-RAY DIFFRACTION' 3.98 4.55  . . 260 5023 99.83  . . . . 0.1354 . . . . . . . . . . . 0.1820 
'X-RAY DIFFRACTION' 4.55 5.72  . . 254 5008 99.17  . . . . 0.1593 . . . . . . . . . . . 0.2184 
'X-RAY DIFFRACTION' 5.72 22.38 . . 261 4833 96.13  . . . . 0.1654 . . . . . . . . . . . 0.1910 
# 
_struct.entry_id                     9C93 
_struct.title                        'Crystal structure of menin in complex with inhibitor compound 26' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9C93 
_struct_keywords.text            'PROTEIN BINDING, PROTEIN BINDING-INHIBITOR COMPLEX' 
_struct_keywords.pdbx_keywords   'PROTEIN BINDING/INHIBITOR' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 5 ? 
G N N 2 ? 
H N N 3 ? 
I N N 6 ? 
J N N 6 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP MEN1_HUMAN O00255 ? 1 
;GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVA
DLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAV
VGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVC
AINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPY
MYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQG
SALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRI
;
2   
2 UNP MEN1_HUMAN O00255 ? 1 TFQSEKMKGMKELLVATKINSSAIKLQLTAQS 552 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9C93 A 20  ? 475 ? O00255 2   ? 457 ? 2   457 
2 2 9C93 A 476 ? 507 ? O00255 552 ? 583 ? 552 583 
3 1 9C93 B 20  ? 475 ? O00255 2   ? 457 ? 2   457 
4 2 9C93 B 476 ? 507 ? O00255 552 ? 583 ? 552 583 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9C93 MET A 1  ? UNP O00255 ?   ? 'initiating methionine' -17 1  
1 9C93 HIS A 2  ? UNP O00255 ?   ? 'expression tag'        -16 2  
1 9C93 HIS A 3  ? UNP O00255 ?   ? 'expression tag'        -15 3  
1 9C93 HIS A 4  ? UNP O00255 ?   ? 'expression tag'        -14 4  
1 9C93 HIS A 5  ? UNP O00255 ?   ? 'expression tag'        -13 5  
1 9C93 HIS A 6  ? UNP O00255 ?   ? 'expression tag'        -12 6  
1 9C93 HIS A 7  ? UNP O00255 ?   ? 'expression tag'        -11 7  
1 9C93 SER A 8  ? UNP O00255 ?   ? 'expression tag'        -10 8  
1 9C93 SER A 9  ? UNP O00255 ?   ? 'expression tag'        -9  9  
1 9C93 GLY A 10 ? UNP O00255 ?   ? 'expression tag'        -8  10 
1 9C93 ARG A 11 ? UNP O00255 ?   ? 'expression tag'        -7  11 
1 9C93 GLU A 12 ? UNP O00255 ?   ? 'expression tag'        -6  12 
1 9C93 ASN A 13 ? UNP O00255 ?   ? 'expression tag'        -5  13 
1 9C93 LEU A 14 ? UNP O00255 ?   ? 'expression tag'        -4  14 
1 9C93 TYR A 15 ? UNP O00255 ?   ? 'expression tag'        -3  15 
1 9C93 PHE A 16 ? UNP O00255 ?   ? 'expression tag'        -2  16 
1 9C93 GLN A 17 ? UNP O00255 ?   ? 'expression tag'        -1  17 
1 9C93 GLY A 18 ? UNP O00255 ?   ? 'expression tag'        0   18 
1 9C93 SER A 19 ? UNP O00255 ?   ? 'expression tag'        1   19 
1 9C93 THR A 23 ? UNP O00255 ALA 5 'engineered mutation'   5   20 
3 9C93 MET B 1  ? UNP O00255 ?   ? 'initiating methionine' -17 21 
3 9C93 HIS B 2  ? UNP O00255 ?   ? 'expression tag'        -16 22 
3 9C93 HIS B 3  ? UNP O00255 ?   ? 'expression tag'        -15 23 
3 9C93 HIS B 4  ? UNP O00255 ?   ? 'expression tag'        -14 24 
3 9C93 HIS B 5  ? UNP O00255 ?   ? 'expression tag'        -13 25 
3 9C93 HIS B 6  ? UNP O00255 ?   ? 'expression tag'        -12 26 
3 9C93 HIS B 7  ? UNP O00255 ?   ? 'expression tag'        -11 27 
3 9C93 SER B 8  ? UNP O00255 ?   ? 'expression tag'        -10 28 
3 9C93 SER B 9  ? UNP O00255 ?   ? 'expression tag'        -9  29 
3 9C93 GLY B 10 ? UNP O00255 ?   ? 'expression tag'        -8  30 
3 9C93 ARG B 11 ? UNP O00255 ?   ? 'expression tag'        -7  31 
3 9C93 GLU B 12 ? UNP O00255 ?   ? 'expression tag'        -6  32 
3 9C93 ASN B 13 ? UNP O00255 ?   ? 'expression tag'        -5  33 
3 9C93 LEU B 14 ? UNP O00255 ?   ? 'expression tag'        -4  34 
3 9C93 TYR B 15 ? UNP O00255 ?   ? 'expression tag'        -3  35 
3 9C93 PHE B 16 ? UNP O00255 ?   ? 'expression tag'        -2  36 
3 9C93 GLN B 17 ? UNP O00255 ?   ? 'expression tag'        -1  37 
3 9C93 GLY B 18 ? UNP O00255 ?   ? 'expression tag'        0   38 
3 9C93 SER B 19 ? UNP O00255 ?   ? 'expression tag'        1   39 
3 9C93 THR B 23 ? UNP O00255 ALA 5 'engineered mutation'   5   40 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,I     
2 1 B,E,F,G,H,J 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 LYS A 22  ? THR A 27  ? LYS A 4   THR A 9   1 ? 6  
HELX_P HELX_P2  AA2 SER A 33  ? GLY A 46  ? SER A 15  GLY A 28  1 ? 14 
HELX_P HELX_P3  AA3 ASP A 51  ? VAL A 68  ? ASP A 33  VAL A 50  1 ? 18 
HELX_P HELX_P4  AA4 ASP A 100 ? VAL A 119 ? ASP A 82  VAL A 101 1 ? 20 
HELX_P HELX_P5  AA5 SER A 132 ? LEU A 147 ? SER A 114 LEU A 129 1 ? 16 
HELX_P HELX_P6  AA6 SER A 160 ? THR A 168 ? SER A 142 THR A 150 1 ? 9  
HELX_P HELX_P7  AA7 ASP A 171 ? LEU A 186 ? ASP A 153 LEU A 168 1 ? 16 
HELX_P HELX_P8  AA8 VAL A 229 ? GLU A 235 ? VAL A 211 GLU A 217 1 ? 7  
HELX_P HELX_P9  AA9 SER A 237 ? SER A 244 ? SER A 219 SER A 226 5 ? 8  
HELX_P HELX_P10 AB1 ASP A 249 ? ALA A 260 ? ASP A 231 ALA A 242 1 ? 12 
HELX_P HELX_P11 AB2 SER A 271 ? LEU A 288 ? SER A 253 LEU A 270 1 ? 18 
HELX_P HELX_P12 AB3 TYR A 294 ? GLU A 308 ? TYR A 276 GLU A 290 1 ? 15 
HELX_P HELX_P13 AB4 ASP A 315 ? ARG A 332 ? ASP A 297 ARG A 314 1 ? 18 
HELX_P HELX_P14 AB5 ILE A 336 ? ASN A 349 ? ILE A 318 ASN A 331 1 ? 14 
HELX_P HELX_P15 AB6 ASN A 351 ? GLN A 367 ? ASN A 333 GLN A 349 1 ? 17 
HELX_P HELX_P16 AB7 CYS A 372 ? GLU A 374 ? CYS A 354 GLU A 356 5 ? 3  
HELX_P HELX_P17 AB8 ASP A 375 ? ASP A 388 ? ASP A 357 ASP A 370 1 ? 14 
HELX_P HELX_P18 AB9 ASP A 388 ? ALA A 403 ? ASP A 370 ALA A 385 1 ? 16 
HELX_P HELX_P19 AC1 SER A 420 ? GLN A 423 ? SER A 402 GLN A 405 5 ? 4  
HELX_P HELX_P20 AC2 ASP A 424 ? GLU A 443 ? ASP A 406 GLU A 425 1 ? 20 
HELX_P HELX_P21 AC3 HIS A 451 ? ARG A 464 ? HIS A 433 ARG A 446 1 ? 14 
HELX_P HELX_P22 AC4 GLU A 466 ? GLN A 471 ? GLU A 448 GLN A 453 1 ? 6  
HELX_P HELX_P23 AC5 SER A 479 ? GLY A 484 ? SER A 555 GLY A 560 1 ? 6  
HELX_P HELX_P24 AC6 MET A 485 ? ALA A 491 ? MET A 561 ALA A 567 1 ? 7  
HELX_P HELX_P25 AC7 ASN A 495 ? THR A 504 ? ASN A 571 THR A 580 1 ? 10 
HELX_P HELX_P26 AC8 LYS B 22  ? THR B 27  ? LYS B 4   THR B 9   1 ? 6  
HELX_P HELX_P27 AC9 SER B 33  ? GLY B 46  ? SER B 15  GLY B 28  1 ? 14 
HELX_P HELX_P28 AD1 ASP B 51  ? ALA B 67  ? ASP B 33  ALA B 49  1 ? 17 
HELX_P HELX_P29 AD2 ASP B 100 ? VAL B 119 ? ASP B 82  VAL B 101 1 ? 20 
HELX_P HELX_P30 AD3 ASP B 120 ? TYR B 124 ? ASP B 102 TYR B 106 5 ? 5  
HELX_P HELX_P31 AD4 SER B 132 ? LEU B 147 ? SER B 114 LEU B 129 1 ? 16 
HELX_P HELX_P32 AD5 SER B 160 ? THR B 168 ? SER B 142 THR B 150 1 ? 9  
HELX_P HELX_P33 AD6 ASP B 171 ? LEU B 186 ? ASP B 153 LEU B 168 1 ? 16 
HELX_P HELX_P34 AD7 VAL B 229 ? GLU B 235 ? VAL B 211 GLU B 217 1 ? 7  
HELX_P HELX_P35 AD8 SER B 237 ? SER B 244 ? SER B 219 SER B 226 5 ? 8  
HELX_P HELX_P36 AD9 ASP B 249 ? ALA B 260 ? ASP B 231 ALA B 242 1 ? 12 
HELX_P HELX_P37 AE1 SER B 271 ? LEU B 288 ? SER B 253 LEU B 270 1 ? 18 
HELX_P HELX_P38 AE2 TYR B 294 ? GLU B 308 ? TYR B 276 GLU B 290 1 ? 15 
HELX_P HELX_P39 AE3 ASP B 315 ? TYR B 331 ? ASP B 297 TYR B 313 1 ? 17 
HELX_P HELX_P40 AE4 ILE B 336 ? ASN B 349 ? ILE B 318 ASN B 331 1 ? 14 
HELX_P HELX_P41 AE5 ASN B 351 ? GLN B 367 ? ASN B 333 GLN B 349 1 ? 17 
HELX_P HELX_P42 AE6 CYS B 372 ? GLU B 374 ? CYS B 354 GLU B 356 5 ? 3  
HELX_P HELX_P43 AE7 ASP B 375 ? ASP B 388 ? ASP B 357 ASP B 370 1 ? 14 
HELX_P HELX_P44 AE8 ASP B 388 ? GLU B 406 ? ASP B 370 GLU B 388 1 ? 19 
HELX_P HELX_P45 AE9 SER B 420 ? GLN B 423 ? SER B 402 GLN B 405 5 ? 4  
HELX_P HELX_P46 AF1 ASP B 424 ? GLU B 443 ? ASP B 406 GLU B 425 1 ? 20 
HELX_P HELX_P47 AF2 HIS B 451 ? ARG B 464 ? HIS B 433 ARG B 446 1 ? 14 
HELX_P HELX_P48 AF3 GLU B 466 ? GLN B 471 ? GLU B 448 GLN B 453 1 ? 6  
HELX_P HELX_P49 AF4 SER B 479 ? MET B 485 ? SER B 555 MET B 561 1 ? 7  
HELX_P HELX_P50 AF5 MET B 485 ? ALA B 491 ? MET B 561 ALA B 567 1 ? 7  
HELX_P HELX_P51 AF6 ASN B 495 ? THR B 504 ? ASN B 571 THR B 580 1 ? 10 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A TYR 369 O   ? ? ? 1_555 D K   . K ? ? A TYR 351 A K   902  1_555 ? ? ? ? ? ? ? 2.956 ? ? 
metalc2  metalc ? ? A ASN 370 OD1 ? ? ? 1_555 D K   . K ? ? A ASN 352 A K   902  1_555 ? ? ? ? ? ? ? 3.427 ? ? 
metalc3  metalc ? ? A LYS 440 O   ? ? ? 1_555 D K   . K ? ? A LYS 422 A K   902  1_555 ? ? ? ? ? ? ? 2.844 ? ? 
metalc4  metalc ? ? A TRP 441 O   ? ? ? 1_555 D K   . K ? ? A TRP 423 A K   902  1_555 ? ? ? ? ? ? ? 2.710 ? ? 
metalc5  metalc ? ? A GLU 443 O   ? ? ? 1_555 D K   . K ? ? A GLU 425 A K   902  1_555 ? ? ? ? ? ? ? 2.822 ? ? 
metalc6  metalc ? ? A SER 445 OG  ? ? ? 1_555 D K   . K ? ? A SER 427 A K   902  1_555 ? ? ? ? ? ? ? 3.483 ? ? 
metalc7  metalc ? ? D K   .   K   ? ? ? 1_555 I HOH . O ? ? A K   902 A HOH 1041 1_555 ? ? ? ? ? ? ? 2.448 ? ? 
metalc8  metalc ? ? B TYR 369 O   ? ? ? 1_555 H K   . K ? ? B TYR 351 B K   604  1_555 ? ? ? ? ? ? ? 2.897 ? ? 
metalc9  metalc ? ? B ASN 370 OD1 ? ? ? 1_555 H K   . K ? ? B ASN 352 B K   604  1_555 ? ? ? ? ? ? ? 2.677 ? ? 
metalc10 metalc ? ? B LYS 440 O   ? ? ? 1_555 H K   . K ? ? B LYS 422 B K   604  1_555 ? ? ? ? ? ? ? 2.693 ? ? 
metalc11 metalc ? ? B TRP 441 O   ? ? ? 1_555 H K   . K ? ? B TRP 423 B K   604  1_555 ? ? ? ? ? ? ? 3.043 ? ? 
metalc12 metalc ? ? B GLU 443 O   ? ? ? 1_555 H K   . K ? ? B GLU 425 B K   604  1_555 ? ? ? ? ? ? ? 2.738 ? ? 
metalc13 metalc ? ? H K   .   K   ? ? ? 1_555 J HOH . O ? ? B K   604 B HOH 780  1_555 ? ? ? ? ? ? ? 2.980 ? ? 
metalc14 metalc ? ? H K   .   K   ? ? ? 1_555 J HOH . O ? ? B K   604 B HOH 957  1_555 ? ? ? ? ? ? ? 2.731 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A TYR 369 ? A TYR 351 ? 1_555 K ? D K . ? A K 902 ? 1_555 OD1 ? A ASN 370 ? A ASN 352  ? 1_555 68.4  ? 
2  O   ? A TYR 369 ? A TYR 351 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A LYS 440 ? A LYS 422  ? 1_555 114.4 ? 
3  OD1 ? A ASN 370 ? A ASN 352 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A LYS 440 ? A LYS 422  ? 1_555 173.5 ? 
4  O   ? A TYR 369 ? A TYR 351 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A TRP 441 ? A TRP 423  ? 1_555 77.5  ? 
5  OD1 ? A ASN 370 ? A ASN 352 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A TRP 441 ? A TRP 423  ? 1_555 112.1 ? 
6  O   ? A LYS 440 ? A LYS 422 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A TRP 441 ? A TRP 423  ? 1_555 74.4  ? 
7  O   ? A TYR 369 ? A TYR 351 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A GLU 443 ? A GLU 425  ? 1_555 156.8 ? 
8  OD1 ? A ASN 370 ? A ASN 352 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A GLU 443 ? A GLU 425  ? 1_555 100.7 ? 
9  O   ? A LYS 440 ? A LYS 422 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A GLU 443 ? A GLU 425  ? 1_555 78.9  ? 
10 O   ? A TRP 441 ? A TRP 423 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? A GLU 443 ? A GLU 425  ? 1_555 88.7  ? 
11 O   ? A TYR 369 ? A TYR 351 ? 1_555 K ? D K . ? A K 902 ? 1_555 OG  ? A SER 445 ? A SER 427  ? 1_555 81.5  ? 
12 OD1 ? A ASN 370 ? A ASN 352 ? 1_555 K ? D K . ? A K 902 ? 1_555 OG  ? A SER 445 ? A SER 427  ? 1_555 71.6  ? 
13 O   ? A LYS 440 ? A LYS 422 ? 1_555 K ? D K . ? A K 902 ? 1_555 OG  ? A SER 445 ? A SER 427  ? 1_555 114.4 ? 
14 O   ? A TRP 441 ? A TRP 423 ? 1_555 K ? D K . ? A K 902 ? 1_555 OG  ? A SER 445 ? A SER 427  ? 1_555 46.0  ? 
15 O   ? A GLU 443 ? A GLU 425 ? 1_555 K ? D K . ? A K 902 ? 1_555 OG  ? A SER 445 ? A SER 427  ? 1_555 75.6  ? 
16 O   ? A TYR 369 ? A TYR 351 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? I HOH .   ? A HOH 1041 ? 1_555 72.8  ? 
17 OD1 ? A ASN 370 ? A ASN 352 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? I HOH .   ? A HOH 1041 ? 1_555 87.0  ? 
18 O   ? A LYS 440 ? A LYS 422 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? I HOH .   ? A HOH 1041 ? 1_555 88.2  ? 
19 O   ? A TRP 441 ? A TRP 423 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? I HOH .   ? A HOH 1041 ? 1_555 135.3 ? 
20 O   ? A GLU 443 ? A GLU 425 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? I HOH .   ? A HOH 1041 ? 1_555 128.5 ? 
21 OG  ? A SER 445 ? A SER 427 ? 1_555 K ? D K . ? A K 902 ? 1_555 O   ? I HOH .   ? A HOH 1041 ? 1_555 151.3 ? 
22 O   ? B TYR 369 ? B TYR 351 ? 1_555 K ? H K . ? B K 604 ? 1_555 OD1 ? B ASN 370 ? B ASN 352  ? 1_555 78.6  ? 
23 O   ? B TYR 369 ? B TYR 351 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B LYS 440 ? B LYS 422  ? 1_555 97.6  ? 
24 OD1 ? B ASN 370 ? B ASN 352 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B LYS 440 ? B LYS 422  ? 1_555 170.8 ? 
25 O   ? B TYR 369 ? B TYR 351 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B TRP 441 ? B TRP 423  ? 1_555 71.7  ? 
26 OD1 ? B ASN 370 ? B ASN 352 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B TRP 441 ? B TRP 423  ? 1_555 112.8 ? 
27 O   ? B LYS 440 ? B LYS 422 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B TRP 441 ? B TRP 423  ? 1_555 73.4  ? 
28 O   ? B TYR 369 ? B TYR 351 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B GLU 443 ? B GLU 425  ? 1_555 144.7 ? 
29 OD1 ? B ASN 370 ? B ASN 352 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B GLU 443 ? B GLU 425  ? 1_555 89.0  ? 
30 O   ? B LYS 440 ? B LYS 422 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B GLU 443 ? B GLU 425  ? 1_555 98.6  ? 
31 O   ? B TRP 441 ? B TRP 423 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? B GLU 443 ? B GLU 425  ? 1_555 83.3  ? 
32 O   ? B TYR 369 ? B TYR 351 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 780  ? 1_555 67.5  ? 
33 OD1 ? B ASN 370 ? B ASN 352 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 780  ? 1_555 87.6  ? 
34 O   ? B LYS 440 ? B LYS 422 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 780  ? 1_555 83.2  ? 
35 O   ? B TRP 441 ? B TRP 423 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 780  ? 1_555 129.1 ? 
36 O   ? B GLU 443 ? B GLU 425 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 780  ? 1_555 145.6 ? 
37 O   ? B TYR 369 ? B TYR 351 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 957  ? 1_555 136.5 ? 
38 OD1 ? B ASN 370 ? B ASN 352 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 957  ? 1_555 73.5  ? 
39 O   ? B LYS 440 ? B LYS 422 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 957  ? 1_555 104.7 ? 
40 O   ? B TRP 441 ? B TRP 423 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 957  ? 1_555 150.5 ? 
41 O   ? B GLU 443 ? B GLU 425 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 957  ? 1_555 67.7  ? 
42 O   ? J HOH .   ? B HOH 780 ? 1_555 K ? H K . ? B K 604 ? 1_555 O   ? J HOH .   ? B HOH 957  ? 1_555 78.5  ? 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 PHE 29 A . ? PHE 11 A PRO 30 A ? PRO 12 A 1 -1.62 
2 PHE 29 B . ? PHE 11 B PRO 30 B ? PRO 12 B 1 0.11  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA3 2 3 ? anti-parallel 
AA3 3 4 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 210 ? ALA A 212 ? GLN A 192 ALA A 194 
AA1 2 ALA A 200 ? PHE A 204 ? ALA A 182 PHE A 186 
AA1 3 HIS A 192 ? LEU A 195 ? HIS A 174 LEU A 177 
AA1 4 MET A 246 ? ARG A 247 ? MET A 228 ARG A 229 
AA2 1 SER A 264 ? ASP A 266 ? SER A 246 ASP A 248 
AA2 2 THR A 269 ? ASP A 270 ? THR A 251 ASP A 252 
AA3 1 GLN B 210 ? ALA B 212 ? GLN B 192 ALA B 194 
AA3 2 ALA B 200 ? PHE B 204 ? ALA B 182 PHE B 186 
AA3 3 HIS B 192 ? LEU B 195 ? HIS B 174 LEU B 177 
AA3 4 MET B 246 ? ARG B 247 ? MET B 228 ARG B 229 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 O GLN A 210 ? O GLN A 192 N PHE A 204 ? N PHE A 186 
AA1 2 3 O TRP A 201 ? O TRP A 183 N ALA A 194 ? N ALA A 176 
AA1 3 4 N LEU A 195 ? N LEU A 177 O MET A 246 ? O MET A 228 
AA2 1 2 N ILE A 265 ? N ILE A 247 O THR A 269 ? O THR A 251 
AA3 1 2 O GLN B 210 ? O GLN B 192 N PHE B 204 ? N PHE B 186 
AA3 2 3 O TRP B 201 ? O TRP B 183 N ALA B 194 ? N ALA B 176 
AA3 3 4 N LEU B 195 ? N LEU B 177 O MET B 246 ? O MET B 228 
# 
_pdbx_entry_details.entry_id                   9C93 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 178 ? ? -90.18  -159.26 
2 1 ASP A 180 ? ? -150.20 2.06    
3 1 ASP A 370 ? ? -146.41 -57.12  
4 1 MET A 561 ? ? -149.08 24.55   
5 1 ALA B 49  ? ? -134.35 -35.93  
6 1 THR B 150 ? ? 39.48   38.65   
7 1 SER B 178 ? ? -93.56  -156.06 
8 1 SER B 226 ? ? -93.12  50.35   
9 1 ASP B 370 ? ? -147.64 -58.47  
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET -17 ? A MET 1   
2  1 Y 1 A HIS -16 ? A HIS 2   
3  1 Y 1 A HIS -15 ? A HIS 3   
4  1 Y 1 A HIS -14 ? A HIS 4   
5  1 Y 1 A HIS -13 ? A HIS 5   
6  1 Y 1 A HIS -12 ? A HIS 6   
7  1 Y 1 A HIS -11 ? A HIS 7   
8  1 Y 1 A SER -10 ? A SER 8   
9  1 Y 1 A SER -9  ? A SER 9   
10 1 Y 1 A GLY -8  ? A GLY 10  
11 1 Y 1 A ARG -7  ? A ARG 11  
12 1 Y 1 A GLU -6  ? A GLU 12  
13 1 Y 1 A ASN -5  ? A ASN 13  
14 1 Y 1 A LEU -4  ? A LEU 14  
15 1 Y 1 A TYR -3  ? A TYR 15  
16 1 Y 1 A PHE -2  ? A PHE 16  
17 1 Y 1 A GLN -1  ? A GLN 17  
18 1 Y 1 A GLY 0   ? A GLY 18  
19 1 Y 1 A SER 1   ? A SER 19  
20 1 Y 1 A ASN 57  ? A ASN 75  
21 1 Y 1 A VAL 58  ? A VAL 76  
22 1 Y 1 A LEU 61  ? A LEU 79  
23 1 Y 1 A THR 62  ? A THR 80  
24 1 Y 1 A SER 104 ? A SER 122 
25 1 Y 1 A LEU 105 ? A LEU 123 
26 1 Y 1 A TYR 106 ? A TYR 124 
27 1 Y 1 A PRO 107 ? A PRO 125 
28 1 Y 1 A ARG 108 ? A ARG 126 
29 1 Y 1 A GLU 109 ? A GLU 127 
30 1 Y 1 A GLY 110 ? A GLY 128 
31 1 Y 1 A LYS 201 ? A LYS 219 
32 1 Y 1 A GLY 202 ? A GLY 220 
33 1 Y 1 A ASN 203 ? A ASN 221 
34 1 Y 1 A GLY 386 ? A GLY 404 
35 1 Y 1 A GLU 387 ? A GLU 405 
36 1 Y 1 A GLU 388 ? A GLU 406 
37 1 Y 1 A ARG 389 ? A ARG 407 
38 1 Y 1 A PRO 390 ? A PRO 408 
39 1 Y 1 A GLY 391 ? A GLY 409 
40 1 Y 1 A GLU 392 ? A GLU 410 
41 1 Y 1 A GLN 393 ? A GLN 411 
42 1 Y 1 A SER 394 ? A SER 412 
43 1 Y 1 A GLN 395 ? A GLN 413 
44 1 Y 1 A GLY 396 ? A GLY 414 
45 1 Y 1 A THR 397 ? A THR 415 
46 1 Y 1 A GLN 398 ? A GLN 416 
47 1 Y 1 A SER 399 ? A SER 417 
48 1 Y 1 A GLN 400 ? A GLN 418 
49 1 Y 1 B MET -17 ? B MET 1   
50 1 Y 1 B HIS -16 ? B HIS 2   
51 1 Y 1 B HIS -15 ? B HIS 3   
52 1 Y 1 B HIS -14 ? B HIS 4   
53 1 Y 1 B HIS -13 ? B HIS 5   
54 1 Y 1 B HIS -12 ? B HIS 6   
55 1 Y 1 B HIS -11 ? B HIS 7   
56 1 Y 1 B SER -10 ? B SER 8   
57 1 Y 1 B SER -9  ? B SER 9   
58 1 Y 1 B GLY -8  ? B GLY 10  
59 1 Y 1 B ARG -7  ? B ARG 11  
60 1 Y 1 B GLU -6  ? B GLU 12  
61 1 Y 1 B ASN -5  ? B ASN 13  
62 1 Y 1 B LEU -4  ? B LEU 14  
63 1 Y 1 B TYR -3  ? B TYR 15  
64 1 Y 1 B PHE -2  ? B PHE 16  
65 1 Y 1 B GLN -1  ? B GLN 17  
66 1 Y 1 B GLY 0   ? B GLY 18  
67 1 Y 1 B SER 1   ? B SER 19  
68 1 Y 1 B GLY 2   ? B GLY 20  
69 1 Y 1 B PRO 107 ? B PRO 125 
70 1 Y 1 B ARG 108 ? B ARG 126 
71 1 Y 1 B GLU 109 ? B GLU 127 
72 1 Y 1 B GLY 110 ? B GLY 128 
73 1 Y 1 B GLY 111 ? B GLY 129 
74 1 Y 1 B ARG 389 ? B ARG 407 
75 1 Y 1 B PRO 390 ? B PRO 408 
76 1 Y 1 B GLY 391 ? B GLY 409 
77 1 Y 1 B GLU 392 ? B GLU 410 
78 1 Y 1 B GLN 393 ? B GLN 411 
79 1 Y 1 B SER 394 ? B SER 412 
80 1 Y 1 B GLN 395 ? B GLN 413 
81 1 Y 1 B GLY 396 ? B GLY 414 
82 1 Y 1 B THR 397 ? B THR 415 
83 1 Y 1 B GLN 398 ? B GLN 416 
84 1 Y 1 B SER 399 ? B SER 417 
85 1 Y 1 B GLN 400 ? B GLN 418 
86 1 Y 1 B SER 583 ? B SER 507 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1AVF N6   N Y N 1   
A1AVF C18  C Y N 2   
A1AVF N5   N Y N 3   
A1AVF C13  C N N 4   
A1AVF C12  C N N 5   
A1AVF C17  C N N 6   
A1AVF C16  C N N 7   
A1AVF C15  C N N 8   
A1AVF C11  C N N 9   
A1AVF C10  C N N 10  
A1AVF C22  C Y N 11  
A1AVF N2   N Y N 12  
A1AVF C1   C Y N 13  
A1AVF C4   C Y N 14  
A1AVF C19  C Y N 15  
A1AVF C20  C Y N 16  
A1AVF C21  C Y N 17  
A1AVF C3   C Y N 18  
A1AVF C23  C Y N 19  
A1AVF C25  C N N 20  
A1AVF C27  C N N 21  
A1AVF C28  C N N 22  
A1AVF C29  C N N 23  
A1AVF C30  C N N 24  
A1AVF C31  C N N 25  
A1AVF C33  C N R 26  
A1AVF C34  C N R 27  
A1AVF C35  C N N 28  
A1AVF C36  C N N 29  
A1AVF C9   C N N 30  
A1AVF F24  F N N 31  
A1AVF N14  N N N 32  
A1AVF N26  N N N 33  
A1AVF N8   N N N 34  
A1AVF O32  O N N 35  
A1AVF O7   O N N 36  
A1AVF H1   H N N 37  
A1AVF H2   H N N 38  
A1AVF H3   H N N 39  
A1AVF H4   H N N 40  
A1AVF H5   H N N 41  
A1AVF H6   H N N 42  
A1AVF H7   H N N 43  
A1AVF H8   H N N 44  
A1AVF H9   H N N 45  
A1AVF H10  H N N 46  
A1AVF H11  H N N 47  
A1AVF H12  H N N 48  
A1AVF H13  H N N 49  
A1AVF H14  H N N 50  
A1AVF H15  H N N 51  
A1AVF H16  H N N 52  
A1AVF H17  H N N 53  
A1AVF H18  H N N 54  
A1AVF H19  H N N 55  
A1AVF H20  H N N 56  
A1AVF H21  H N N 57  
A1AVF H22  H N N 58  
A1AVF H23  H N N 59  
A1AVF H24  H N N 60  
A1AVF H25  H N N 61  
A1AVF H26  H N N 62  
A1AVF H27  H N N 63  
A1AVF H28  H N N 64  
A1AVF H29  H N N 65  
A1AVF H30  H N N 66  
A1AVF H31  H N N 67  
A1AVF H32  H N N 68  
A1AVF H33  H N N 69  
ALA   N    N N N 70  
ALA   CA   C N S 71  
ALA   C    C N N 72  
ALA   O    O N N 73  
ALA   CB   C N N 74  
ALA   OXT  O N N 75  
ALA   H    H N N 76  
ALA   H2   H N N 77  
ALA   HA   H N N 78  
ALA   HB1  H N N 79  
ALA   HB2  H N N 80  
ALA   HB3  H N N 81  
ALA   HXT  H N N 82  
ARG   N    N N N 83  
ARG   CA   C N S 84  
ARG   C    C N N 85  
ARG   O    O N N 86  
ARG   CB   C N N 87  
ARG   CG   C N N 88  
ARG   CD   C N N 89  
ARG   NE   N N N 90  
ARG   CZ   C N N 91  
ARG   NH1  N N N 92  
ARG   NH2  N N N 93  
ARG   OXT  O N N 94  
ARG   H    H N N 95  
ARG   H2   H N N 96  
ARG   HA   H N N 97  
ARG   HB2  H N N 98  
ARG   HB3  H N N 99  
ARG   HG2  H N N 100 
ARG   HG3  H N N 101 
ARG   HD2  H N N 102 
ARG   HD3  H N N 103 
ARG   HE   H N N 104 
ARG   HH11 H N N 105 
ARG   HH12 H N N 106 
ARG   HH21 H N N 107 
ARG   HH22 H N N 108 
ARG   HXT  H N N 109 
ASN   N    N N N 110 
ASN   CA   C N S 111 
ASN   C    C N N 112 
ASN   O    O N N 113 
ASN   CB   C N N 114 
ASN   CG   C N N 115 
ASN   OD1  O N N 116 
ASN   ND2  N N N 117 
ASN   OXT  O N N 118 
ASN   H    H N N 119 
ASN   H2   H N N 120 
ASN   HA   H N N 121 
ASN   HB2  H N N 122 
ASN   HB3  H N N 123 
ASN   HD21 H N N 124 
ASN   HD22 H N N 125 
ASN   HXT  H N N 126 
ASP   N    N N N 127 
ASP   CA   C N S 128 
ASP   C    C N N 129 
ASP   O    O N N 130 
ASP   CB   C N N 131 
ASP   CG   C N N 132 
ASP   OD1  O N N 133 
ASP   OD2  O N N 134 
ASP   OXT  O N N 135 
ASP   H    H N N 136 
ASP   H2   H N N 137 
ASP   HA   H N N 138 
ASP   HB2  H N N 139 
ASP   HB3  H N N 140 
ASP   HD2  H N N 141 
ASP   HXT  H N N 142 
CYS   N    N N N 143 
CYS   CA   C N R 144 
CYS   C    C N N 145 
CYS   O    O N N 146 
CYS   CB   C N N 147 
CYS   SG   S N N 148 
CYS   OXT  O N N 149 
CYS   H    H N N 150 
CYS   H2   H N N 151 
CYS   HA   H N N 152 
CYS   HB2  H N N 153 
CYS   HB3  H N N 154 
CYS   HG   H N N 155 
CYS   HXT  H N N 156 
EPE   N1   N N N 157 
EPE   C2   C N N 158 
EPE   C3   C N N 159 
EPE   N4   N N N 160 
EPE   C5   C N N 161 
EPE   C6   C N N 162 
EPE   C7   C N N 163 
EPE   C8   C N N 164 
EPE   O8   O N N 165 
EPE   C9   C N N 166 
EPE   C10  C N N 167 
EPE   S    S N N 168 
EPE   O1S  O N N 169 
EPE   O2S  O N N 170 
EPE   O3S  O N N 171 
EPE   H21  H N N 172 
EPE   H22  H N N 173 
EPE   H31  H N N 174 
EPE   H32  H N N 175 
EPE   H51  H N N 176 
EPE   H52  H N N 177 
EPE   H61  H N N 178 
EPE   H62  H N N 179 
EPE   H71  H N N 180 
EPE   H72  H N N 181 
EPE   H81  H N N 182 
EPE   H82  H N N 183 
EPE   HO8  H N N 184 
EPE   H91  H N N 185 
EPE   H92  H N N 186 
EPE   H101 H N N 187 
EPE   H102 H N N 188 
EPE   HOS3 H N N 189 
GLN   N    N N N 190 
GLN   CA   C N S 191 
GLN   C    C N N 192 
GLN   O    O N N 193 
GLN   CB   C N N 194 
GLN   CG   C N N 195 
GLN   CD   C N N 196 
GLN   OE1  O N N 197 
GLN   NE2  N N N 198 
GLN   OXT  O N N 199 
GLN   H    H N N 200 
GLN   H2   H N N 201 
GLN   HA   H N N 202 
GLN   HB2  H N N 203 
GLN   HB3  H N N 204 
GLN   HG2  H N N 205 
GLN   HG3  H N N 206 
GLN   HE21 H N N 207 
GLN   HE22 H N N 208 
GLN   HXT  H N N 209 
GLU   N    N N N 210 
GLU   CA   C N S 211 
GLU   C    C N N 212 
GLU   O    O N N 213 
GLU   CB   C N N 214 
GLU   CG   C N N 215 
GLU   CD   C N N 216 
GLU   OE1  O N N 217 
GLU   OE2  O N N 218 
GLU   OXT  O N N 219 
GLU   H    H N N 220 
GLU   H2   H N N 221 
GLU   HA   H N N 222 
GLU   HB2  H N N 223 
GLU   HB3  H N N 224 
GLU   HG2  H N N 225 
GLU   HG3  H N N 226 
GLU   HE2  H N N 227 
GLU   HXT  H N N 228 
GLY   N    N N N 229 
GLY   CA   C N N 230 
GLY   C    C N N 231 
GLY   O    O N N 232 
GLY   OXT  O N N 233 
GLY   H    H N N 234 
GLY   H2   H N N 235 
GLY   HA2  H N N 236 
GLY   HA3  H N N 237 
GLY   HXT  H N N 238 
HIS   N    N N N 239 
HIS   CA   C N S 240 
HIS   C    C N N 241 
HIS   O    O N N 242 
HIS   CB   C N N 243 
HIS   CG   C Y N 244 
HIS   ND1  N Y N 245 
HIS   CD2  C Y N 246 
HIS   CE1  C Y N 247 
HIS   NE2  N Y N 248 
HIS   OXT  O N N 249 
HIS   H    H N N 250 
HIS   H2   H N N 251 
HIS   HA   H N N 252 
HIS   HB2  H N N 253 
HIS   HB3  H N N 254 
HIS   HD1  H N N 255 
HIS   HD2  H N N 256 
HIS   HE1  H N N 257 
HIS   HE2  H N N 258 
HIS   HXT  H N N 259 
HOH   O    O N N 260 
HOH   H1   H N N 261 
HOH   H2   H N N 262 
ILE   N    N N N 263 
ILE   CA   C N S 264 
ILE   C    C N N 265 
ILE   O    O N N 266 
ILE   CB   C N S 267 
ILE   CG1  C N N 268 
ILE   CG2  C N N 269 
ILE   CD1  C N N 270 
ILE   OXT  O N N 271 
ILE   H    H N N 272 
ILE   H2   H N N 273 
ILE   HA   H N N 274 
ILE   HB   H N N 275 
ILE   HG12 H N N 276 
ILE   HG13 H N N 277 
ILE   HG21 H N N 278 
ILE   HG22 H N N 279 
ILE   HG23 H N N 280 
ILE   HD11 H N N 281 
ILE   HD12 H N N 282 
ILE   HD13 H N N 283 
ILE   HXT  H N N 284 
K     K    K N N 285 
LEU   N    N N N 286 
LEU   CA   C N S 287 
LEU   C    C N N 288 
LEU   O    O N N 289 
LEU   CB   C N N 290 
LEU   CG   C N N 291 
LEU   CD1  C N N 292 
LEU   CD2  C N N 293 
LEU   OXT  O N N 294 
LEU   H    H N N 295 
LEU   H2   H N N 296 
LEU   HA   H N N 297 
LEU   HB2  H N N 298 
LEU   HB3  H N N 299 
LEU   HG   H N N 300 
LEU   HD11 H N N 301 
LEU   HD12 H N N 302 
LEU   HD13 H N N 303 
LEU   HD21 H N N 304 
LEU   HD22 H N N 305 
LEU   HD23 H N N 306 
LEU   HXT  H N N 307 
LYS   N    N N N 308 
LYS   CA   C N S 309 
LYS   C    C N N 310 
LYS   O    O N N 311 
LYS   CB   C N N 312 
LYS   CG   C N N 313 
LYS   CD   C N N 314 
LYS   CE   C N N 315 
LYS   NZ   N N N 316 
LYS   OXT  O N N 317 
LYS   H    H N N 318 
LYS   H2   H N N 319 
LYS   HA   H N N 320 
LYS   HB2  H N N 321 
LYS   HB3  H N N 322 
LYS   HG2  H N N 323 
LYS   HG3  H N N 324 
LYS   HD2  H N N 325 
LYS   HD3  H N N 326 
LYS   HE2  H N N 327 
LYS   HE3  H N N 328 
LYS   HZ1  H N N 329 
LYS   HZ2  H N N 330 
LYS   HZ3  H N N 331 
LYS   HXT  H N N 332 
MET   N    N N N 333 
MET   CA   C N S 334 
MET   C    C N N 335 
MET   O    O N N 336 
MET   CB   C N N 337 
MET   CG   C N N 338 
MET   SD   S N N 339 
MET   CE   C N N 340 
MET   OXT  O N N 341 
MET   H    H N N 342 
MET   H2   H N N 343 
MET   HA   H N N 344 
MET   HB2  H N N 345 
MET   HB3  H N N 346 
MET   HG2  H N N 347 
MET   HG3  H N N 348 
MET   HE1  H N N 349 
MET   HE2  H N N 350 
MET   HE3  H N N 351 
MET   HXT  H N N 352 
PHE   N    N N N 353 
PHE   CA   C N S 354 
PHE   C    C N N 355 
PHE   O    O N N 356 
PHE   CB   C N N 357 
PHE   CG   C Y N 358 
PHE   CD1  C Y N 359 
PHE   CD2  C Y N 360 
PHE   CE1  C Y N 361 
PHE   CE2  C Y N 362 
PHE   CZ   C Y N 363 
PHE   OXT  O N N 364 
PHE   H    H N N 365 
PHE   H2   H N N 366 
PHE   HA   H N N 367 
PHE   HB2  H N N 368 
PHE   HB3  H N N 369 
PHE   HD1  H N N 370 
PHE   HD2  H N N 371 
PHE   HE1  H N N 372 
PHE   HE2  H N N 373 
PHE   HZ   H N N 374 
PHE   HXT  H N N 375 
PRO   N    N N N 376 
PRO   CA   C N S 377 
PRO   C    C N N 378 
PRO   O    O N N 379 
PRO   CB   C N N 380 
PRO   CG   C N N 381 
PRO   CD   C N N 382 
PRO   OXT  O N N 383 
PRO   H    H N N 384 
PRO   HA   H N N 385 
PRO   HB2  H N N 386 
PRO   HB3  H N N 387 
PRO   HG2  H N N 388 
PRO   HG3  H N N 389 
PRO   HD2  H N N 390 
PRO   HD3  H N N 391 
PRO   HXT  H N N 392 
SER   N    N N N 393 
SER   CA   C N S 394 
SER   C    C N N 395 
SER   O    O N N 396 
SER   CB   C N N 397 
SER   OG   O N N 398 
SER   OXT  O N N 399 
SER   H    H N N 400 
SER   H2   H N N 401 
SER   HA   H N N 402 
SER   HB2  H N N 403 
SER   HB3  H N N 404 
SER   HG   H N N 405 
SER   HXT  H N N 406 
SO4   S    S N N 407 
SO4   O1   O N N 408 
SO4   O2   O N N 409 
SO4   O3   O N N 410 
SO4   O4   O N N 411 
THR   N    N N N 412 
THR   CA   C N S 413 
THR   C    C N N 414 
THR   O    O N N 415 
THR   CB   C N R 416 
THR   OG1  O N N 417 
THR   CG2  C N N 418 
THR   OXT  O N N 419 
THR   H    H N N 420 
THR   H2   H N N 421 
THR   HA   H N N 422 
THR   HB   H N N 423 
THR   HG1  H N N 424 
THR   HG21 H N N 425 
THR   HG22 H N N 426 
THR   HG23 H N N 427 
THR   HXT  H N N 428 
TRP   N    N N N 429 
TRP   CA   C N S 430 
TRP   C    C N N 431 
TRP   O    O N N 432 
TRP   CB   C N N 433 
TRP   CG   C Y N 434 
TRP   CD1  C Y N 435 
TRP   CD2  C Y N 436 
TRP   NE1  N Y N 437 
TRP   CE2  C Y N 438 
TRP   CE3  C Y N 439 
TRP   CZ2  C Y N 440 
TRP   CZ3  C Y N 441 
TRP   CH2  C Y N 442 
TRP   OXT  O N N 443 
TRP   H    H N N 444 
TRP   H2   H N N 445 
TRP   HA   H N N 446 
TRP   HB2  H N N 447 
TRP   HB3  H N N 448 
TRP   HD1  H N N 449 
TRP   HE1  H N N 450 
TRP   HE3  H N N 451 
TRP   HZ2  H N N 452 
TRP   HZ3  H N N 453 
TRP   HH2  H N N 454 
TRP   HXT  H N N 455 
TYR   N    N N N 456 
TYR   CA   C N S 457 
TYR   C    C N N 458 
TYR   O    O N N 459 
TYR   CB   C N N 460 
TYR   CG   C Y N 461 
TYR   CD1  C Y N 462 
TYR   CD2  C Y N 463 
TYR   CE1  C Y N 464 
TYR   CE2  C Y N 465 
TYR   CZ   C Y N 466 
TYR   OH   O N N 467 
TYR   OXT  O N N 468 
TYR   H    H N N 469 
TYR   H2   H N N 470 
TYR   HA   H N N 471 
TYR   HB2  H N N 472 
TYR   HB3  H N N 473 
TYR   HD1  H N N 474 
TYR   HD2  H N N 475 
TYR   HE1  H N N 476 
TYR   HE2  H N N 477 
TYR   HH   H N N 478 
TYR   HXT  H N N 479 
VAL   N    N N N 480 
VAL   CA   C N S 481 
VAL   C    C N N 482 
VAL   O    O N N 483 
VAL   CB   C N N 484 
VAL   CG1  C N N 485 
VAL   CG2  C N N 486 
VAL   OXT  O N N 487 
VAL   H    H N N 488 
VAL   H2   H N N 489 
VAL   HA   H N N 490 
VAL   HB   H N N 491 
VAL   HG11 H N N 492 
VAL   HG12 H N N 493 
VAL   HG13 H N N 494 
VAL   HG21 H N N 495 
VAL   HG22 H N N 496 
VAL   HG23 H N N 497 
VAL   HXT  H N N 498 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1AVF C35 C34  sing N N 1   
A1AVF C35 C31  sing N N 2   
A1AVF C1  N2   doub Y N 3   
A1AVF C1  N6   sing Y N 4   
A1AVF N2  C3   sing Y N 5   
A1AVF C28 C29  sing N N 6   
A1AVF C28 C27  sing N N 7   
A1AVF C15 N14  sing N N 8   
A1AVF C15 C16  sing N N 9   
A1AVF C17 C27  sing N N 10  
A1AVF C17 N14  sing N N 11  
A1AVF C34 C36  sing N N 12  
A1AVF C34 C33  sing N N 13  
A1AVF C11 N8   sing N N 14  
A1AVF C11 C10  sing N N 15  
A1AVF C29 C27  sing N N 16  
A1AVF O32 C31  doub N N 17  
A1AVF C27 C30  sing N N 18  
A1AVF C36 C33  sing N N 19  
A1AVF C31 N26  sing N N 20  
A1AVF N6  N5   doub Y N 21  
A1AVF N14 C13  sing N N 22  
A1AVF C16 C10  sing N N 23  
A1AVF C3  N8   sing N N 24  
A1AVF C3  C4   doub Y N 25  
A1AVF N8  C9   sing N N 26  
A1AVF C13 C12  sing N N 27  
A1AVF C10 C9   sing N N 28  
A1AVF C10 C12  sing N N 29  
A1AVF C33 N26  sing N N 30  
A1AVF N26 C25  sing N N 31  
A1AVF N5  C4   sing Y N 32  
A1AVF C4  O7   sing N N 33  
A1AVF O7  C18  sing N N 34  
A1AVF C25 C19  sing N N 35  
A1AVF C18 C19  doub Y N 36  
A1AVF C18 C23  sing Y N 37  
A1AVF C19 C20  sing Y N 38  
A1AVF C23 C22  doub Y N 39  
A1AVF C20 C21  doub Y N 40  
A1AVF C22 C21  sing Y N 41  
A1AVF C21 F24  sing N N 42  
A1AVF C13 H1   sing N N 43  
A1AVF C13 H2   sing N N 44  
A1AVF C12 H3   sing N N 45  
A1AVF C12 H4   sing N N 46  
A1AVF C17 H5   sing N N 47  
A1AVF C17 H6   sing N N 48  
A1AVF C16 H7   sing N N 49  
A1AVF C16 H8   sing N N 50  
A1AVF C15 H9   sing N N 51  
A1AVF C15 H10  sing N N 52  
A1AVF C11 H11  sing N N 53  
A1AVF C11 H12  sing N N 54  
A1AVF C22 H13  sing N N 55  
A1AVF C1  H14  sing N N 56  
A1AVF C20 H15  sing N N 57  
A1AVF C23 H16  sing N N 58  
A1AVF C25 H17  sing N N 59  
A1AVF C25 H18  sing N N 60  
A1AVF C28 H19  sing N N 61  
A1AVF C28 H20  sing N N 62  
A1AVF C29 H21  sing N N 63  
A1AVF C29 H22  sing N N 64  
A1AVF C30 H23  sing N N 65  
A1AVF C30 H24  sing N N 66  
A1AVF C30 H25  sing N N 67  
A1AVF C33 H26  sing N N 68  
A1AVF C34 H27  sing N N 69  
A1AVF C35 H28  sing N N 70  
A1AVF C35 H29  sing N N 71  
A1AVF C36 H30  sing N N 72  
A1AVF C36 H31  sing N N 73  
A1AVF C9  H32  sing N N 74  
A1AVF C9  H33  sing N N 75  
ALA   N   CA   sing N N 76  
ALA   N   H    sing N N 77  
ALA   N   H2   sing N N 78  
ALA   CA  C    sing N N 79  
ALA   CA  CB   sing N N 80  
ALA   CA  HA   sing N N 81  
ALA   C   O    doub N N 82  
ALA   C   OXT  sing N N 83  
ALA   CB  HB1  sing N N 84  
ALA   CB  HB2  sing N N 85  
ALA   CB  HB3  sing N N 86  
ALA   OXT HXT  sing N N 87  
ARG   N   CA   sing N N 88  
ARG   N   H    sing N N 89  
ARG   N   H2   sing N N 90  
ARG   CA  C    sing N N 91  
ARG   CA  CB   sing N N 92  
ARG   CA  HA   sing N N 93  
ARG   C   O    doub N N 94  
ARG   C   OXT  sing N N 95  
ARG   CB  CG   sing N N 96  
ARG   CB  HB2  sing N N 97  
ARG   CB  HB3  sing N N 98  
ARG   CG  CD   sing N N 99  
ARG   CG  HG2  sing N N 100 
ARG   CG  HG3  sing N N 101 
ARG   CD  NE   sing N N 102 
ARG   CD  HD2  sing N N 103 
ARG   CD  HD3  sing N N 104 
ARG   NE  CZ   sing N N 105 
ARG   NE  HE   sing N N 106 
ARG   CZ  NH1  sing N N 107 
ARG   CZ  NH2  doub N N 108 
ARG   NH1 HH11 sing N N 109 
ARG   NH1 HH12 sing N N 110 
ARG   NH2 HH21 sing N N 111 
ARG   NH2 HH22 sing N N 112 
ARG   OXT HXT  sing N N 113 
ASN   N   CA   sing N N 114 
ASN   N   H    sing N N 115 
ASN   N   H2   sing N N 116 
ASN   CA  C    sing N N 117 
ASN   CA  CB   sing N N 118 
ASN   CA  HA   sing N N 119 
ASN   C   O    doub N N 120 
ASN   C   OXT  sing N N 121 
ASN   CB  CG   sing N N 122 
ASN   CB  HB2  sing N N 123 
ASN   CB  HB3  sing N N 124 
ASN   CG  OD1  doub N N 125 
ASN   CG  ND2  sing N N 126 
ASN   ND2 HD21 sing N N 127 
ASN   ND2 HD22 sing N N 128 
ASN   OXT HXT  sing N N 129 
ASP   N   CA   sing N N 130 
ASP   N   H    sing N N 131 
ASP   N   H2   sing N N 132 
ASP   CA  C    sing N N 133 
ASP   CA  CB   sing N N 134 
ASP   CA  HA   sing N N 135 
ASP   C   O    doub N N 136 
ASP   C   OXT  sing N N 137 
ASP   CB  CG   sing N N 138 
ASP   CB  HB2  sing N N 139 
ASP   CB  HB3  sing N N 140 
ASP   CG  OD1  doub N N 141 
ASP   CG  OD2  sing N N 142 
ASP   OD2 HD2  sing N N 143 
ASP   OXT HXT  sing N N 144 
CYS   N   CA   sing N N 145 
CYS   N   H    sing N N 146 
CYS   N   H2   sing N N 147 
CYS   CA  C    sing N N 148 
CYS   CA  CB   sing N N 149 
CYS   CA  HA   sing N N 150 
CYS   C   O    doub N N 151 
CYS   C   OXT  sing N N 152 
CYS   CB  SG   sing N N 153 
CYS   CB  HB2  sing N N 154 
CYS   CB  HB3  sing N N 155 
CYS   SG  HG   sing N N 156 
CYS   OXT HXT  sing N N 157 
EPE   N1  C2   sing N N 158 
EPE   N1  C6   sing N N 159 
EPE   N1  C9   sing N N 160 
EPE   C2  C3   sing N N 161 
EPE   C2  H21  sing N N 162 
EPE   C2  H22  sing N N 163 
EPE   C3  N4   sing N N 164 
EPE   C3  H31  sing N N 165 
EPE   C3  H32  sing N N 166 
EPE   N4  C5   sing N N 167 
EPE   N4  C7   sing N N 168 
EPE   C5  C6   sing N N 169 
EPE   C5  H51  sing N N 170 
EPE   C5  H52  sing N N 171 
EPE   C6  H61  sing N N 172 
EPE   C6  H62  sing N N 173 
EPE   C7  C8   sing N N 174 
EPE   C7  H71  sing N N 175 
EPE   C7  H72  sing N N 176 
EPE   C8  O8   sing N N 177 
EPE   C8  H81  sing N N 178 
EPE   C8  H82  sing N N 179 
EPE   O8  HO8  sing N N 180 
EPE   C9  C10  sing N N 181 
EPE   C9  H91  sing N N 182 
EPE   C9  H92  sing N N 183 
EPE   C10 S    sing N N 184 
EPE   C10 H101 sing N N 185 
EPE   C10 H102 sing N N 186 
EPE   S   O1S  doub N N 187 
EPE   S   O2S  doub N N 188 
EPE   S   O3S  sing N N 189 
EPE   O3S HOS3 sing N N 190 
GLN   N   CA   sing N N 191 
GLN   N   H    sing N N 192 
GLN   N   H2   sing N N 193 
GLN   CA  C    sing N N 194 
GLN   CA  CB   sing N N 195 
GLN   CA  HA   sing N N 196 
GLN   C   O    doub N N 197 
GLN   C   OXT  sing N N 198 
GLN   CB  CG   sing N N 199 
GLN   CB  HB2  sing N N 200 
GLN   CB  HB3  sing N N 201 
GLN   CG  CD   sing N N 202 
GLN   CG  HG2  sing N N 203 
GLN   CG  HG3  sing N N 204 
GLN   CD  OE1  doub N N 205 
GLN   CD  NE2  sing N N 206 
GLN   NE2 HE21 sing N N 207 
GLN   NE2 HE22 sing N N 208 
GLN   OXT HXT  sing N N 209 
GLU   N   CA   sing N N 210 
GLU   N   H    sing N N 211 
GLU   N   H2   sing N N 212 
GLU   CA  C    sing N N 213 
GLU   CA  CB   sing N N 214 
GLU   CA  HA   sing N N 215 
GLU   C   O    doub N N 216 
GLU   C   OXT  sing N N 217 
GLU   CB  CG   sing N N 218 
GLU   CB  HB2  sing N N 219 
GLU   CB  HB3  sing N N 220 
GLU   CG  CD   sing N N 221 
GLU   CG  HG2  sing N N 222 
GLU   CG  HG3  sing N N 223 
GLU   CD  OE1  doub N N 224 
GLU   CD  OE2  sing N N 225 
GLU   OE2 HE2  sing N N 226 
GLU   OXT HXT  sing N N 227 
GLY   N   CA   sing N N 228 
GLY   N   H    sing N N 229 
GLY   N   H2   sing N N 230 
GLY   CA  C    sing N N 231 
GLY   CA  HA2  sing N N 232 
GLY   CA  HA3  sing N N 233 
GLY   C   O    doub N N 234 
GLY   C   OXT  sing N N 235 
GLY   OXT HXT  sing N N 236 
HIS   N   CA   sing N N 237 
HIS   N   H    sing N N 238 
HIS   N   H2   sing N N 239 
HIS   CA  C    sing N N 240 
HIS   CA  CB   sing N N 241 
HIS   CA  HA   sing N N 242 
HIS   C   O    doub N N 243 
HIS   C   OXT  sing N N 244 
HIS   CB  CG   sing N N 245 
HIS   CB  HB2  sing N N 246 
HIS   CB  HB3  sing N N 247 
HIS   CG  ND1  sing Y N 248 
HIS   CG  CD2  doub Y N 249 
HIS   ND1 CE1  doub Y N 250 
HIS   ND1 HD1  sing N N 251 
HIS   CD2 NE2  sing Y N 252 
HIS   CD2 HD2  sing N N 253 
HIS   CE1 NE2  sing Y N 254 
HIS   CE1 HE1  sing N N 255 
HIS   NE2 HE2  sing N N 256 
HIS   OXT HXT  sing N N 257 
HOH   O   H1   sing N N 258 
HOH   O   H2   sing N N 259 
ILE   N   CA   sing N N 260 
ILE   N   H    sing N N 261 
ILE   N   H2   sing N N 262 
ILE   CA  C    sing N N 263 
ILE   CA  CB   sing N N 264 
ILE   CA  HA   sing N N 265 
ILE   C   O    doub N N 266 
ILE   C   OXT  sing N N 267 
ILE   CB  CG1  sing N N 268 
ILE   CB  CG2  sing N N 269 
ILE   CB  HB   sing N N 270 
ILE   CG1 CD1  sing N N 271 
ILE   CG1 HG12 sing N N 272 
ILE   CG1 HG13 sing N N 273 
ILE   CG2 HG21 sing N N 274 
ILE   CG2 HG22 sing N N 275 
ILE   CG2 HG23 sing N N 276 
ILE   CD1 HD11 sing N N 277 
ILE   CD1 HD12 sing N N 278 
ILE   CD1 HD13 sing N N 279 
ILE   OXT HXT  sing N N 280 
LEU   N   CA   sing N N 281 
LEU   N   H    sing N N 282 
LEU   N   H2   sing N N 283 
LEU   CA  C    sing N N 284 
LEU   CA  CB   sing N N 285 
LEU   CA  HA   sing N N 286 
LEU   C   O    doub N N 287 
LEU   C   OXT  sing N N 288 
LEU   CB  CG   sing N N 289 
LEU   CB  HB2  sing N N 290 
LEU   CB  HB3  sing N N 291 
LEU   CG  CD1  sing N N 292 
LEU   CG  CD2  sing N N 293 
LEU   CG  HG   sing N N 294 
LEU   CD1 HD11 sing N N 295 
LEU   CD1 HD12 sing N N 296 
LEU   CD1 HD13 sing N N 297 
LEU   CD2 HD21 sing N N 298 
LEU   CD2 HD22 sing N N 299 
LEU   CD2 HD23 sing N N 300 
LEU   OXT HXT  sing N N 301 
LYS   N   CA   sing N N 302 
LYS   N   H    sing N N 303 
LYS   N   H2   sing N N 304 
LYS   CA  C    sing N N 305 
LYS   CA  CB   sing N N 306 
LYS   CA  HA   sing N N 307 
LYS   C   O    doub N N 308 
LYS   C   OXT  sing N N 309 
LYS   CB  CG   sing N N 310 
LYS   CB  HB2  sing N N 311 
LYS   CB  HB3  sing N N 312 
LYS   CG  CD   sing N N 313 
LYS   CG  HG2  sing N N 314 
LYS   CG  HG3  sing N N 315 
LYS   CD  CE   sing N N 316 
LYS   CD  HD2  sing N N 317 
LYS   CD  HD3  sing N N 318 
LYS   CE  NZ   sing N N 319 
LYS   CE  HE2  sing N N 320 
LYS   CE  HE3  sing N N 321 
LYS   NZ  HZ1  sing N N 322 
LYS   NZ  HZ2  sing N N 323 
LYS   NZ  HZ3  sing N N 324 
LYS   OXT HXT  sing N N 325 
MET   N   CA   sing N N 326 
MET   N   H    sing N N 327 
MET   N   H2   sing N N 328 
MET   CA  C    sing N N 329 
MET   CA  CB   sing N N 330 
MET   CA  HA   sing N N 331 
MET   C   O    doub N N 332 
MET   C   OXT  sing N N 333 
MET   CB  CG   sing N N 334 
MET   CB  HB2  sing N N 335 
MET   CB  HB3  sing N N 336 
MET   CG  SD   sing N N 337 
MET   CG  HG2  sing N N 338 
MET   CG  HG3  sing N N 339 
MET   SD  CE   sing N N 340 
MET   CE  HE1  sing N N 341 
MET   CE  HE2  sing N N 342 
MET   CE  HE3  sing N N 343 
MET   OXT HXT  sing N N 344 
PHE   N   CA   sing N N 345 
PHE   N   H    sing N N 346 
PHE   N   H2   sing N N 347 
PHE   CA  C    sing N N 348 
PHE   CA  CB   sing N N 349 
PHE   CA  HA   sing N N 350 
PHE   C   O    doub N N 351 
PHE   C   OXT  sing N N 352 
PHE   CB  CG   sing N N 353 
PHE   CB  HB2  sing N N 354 
PHE   CB  HB3  sing N N 355 
PHE   CG  CD1  doub Y N 356 
PHE   CG  CD2  sing Y N 357 
PHE   CD1 CE1  sing Y N 358 
PHE   CD1 HD1  sing N N 359 
PHE   CD2 CE2  doub Y N 360 
PHE   CD2 HD2  sing N N 361 
PHE   CE1 CZ   doub Y N 362 
PHE   CE1 HE1  sing N N 363 
PHE   CE2 CZ   sing Y N 364 
PHE   CE2 HE2  sing N N 365 
PHE   CZ  HZ   sing N N 366 
PHE   OXT HXT  sing N N 367 
PRO   N   CA   sing N N 368 
PRO   N   CD   sing N N 369 
PRO   N   H    sing N N 370 
PRO   CA  C    sing N N 371 
PRO   CA  CB   sing N N 372 
PRO   CA  HA   sing N N 373 
PRO   C   O    doub N N 374 
PRO   C   OXT  sing N N 375 
PRO   CB  CG   sing N N 376 
PRO   CB  HB2  sing N N 377 
PRO   CB  HB3  sing N N 378 
PRO   CG  CD   sing N N 379 
PRO   CG  HG2  sing N N 380 
PRO   CG  HG3  sing N N 381 
PRO   CD  HD2  sing N N 382 
PRO   CD  HD3  sing N N 383 
PRO   OXT HXT  sing N N 384 
SER   N   CA   sing N N 385 
SER   N   H    sing N N 386 
SER   N   H2   sing N N 387 
SER   CA  C    sing N N 388 
SER   CA  CB   sing N N 389 
SER   CA  HA   sing N N 390 
SER   C   O    doub N N 391 
SER   C   OXT  sing N N 392 
SER   CB  OG   sing N N 393 
SER   CB  HB2  sing N N 394 
SER   CB  HB3  sing N N 395 
SER   OG  HG   sing N N 396 
SER   OXT HXT  sing N N 397 
SO4   S   O1   doub N N 398 
SO4   S   O2   doub N N 399 
SO4   S   O3   sing N N 400 
SO4   S   O4   sing N N 401 
THR   N   CA   sing N N 402 
THR   N   H    sing N N 403 
THR   N   H2   sing N N 404 
THR   CA  C    sing N N 405 
THR   CA  CB   sing N N 406 
THR   CA  HA   sing N N 407 
THR   C   O    doub N N 408 
THR   C   OXT  sing N N 409 
THR   CB  OG1  sing N N 410 
THR   CB  CG2  sing N N 411 
THR   CB  HB   sing N N 412 
THR   OG1 HG1  sing N N 413 
THR   CG2 HG21 sing N N 414 
THR   CG2 HG22 sing N N 415 
THR   CG2 HG23 sing N N 416 
THR   OXT HXT  sing N N 417 
TRP   N   CA   sing N N 418 
TRP   N   H    sing N N 419 
TRP   N   H2   sing N N 420 
TRP   CA  C    sing N N 421 
TRP   CA  CB   sing N N 422 
TRP   CA  HA   sing N N 423 
TRP   C   O    doub N N 424 
TRP   C   OXT  sing N N 425 
TRP   CB  CG   sing N N 426 
TRP   CB  HB2  sing N N 427 
TRP   CB  HB3  sing N N 428 
TRP   CG  CD1  doub Y N 429 
TRP   CG  CD2  sing Y N 430 
TRP   CD1 NE1  sing Y N 431 
TRP   CD1 HD1  sing N N 432 
TRP   CD2 CE2  doub Y N 433 
TRP   CD2 CE3  sing Y N 434 
TRP   NE1 CE2  sing Y N 435 
TRP   NE1 HE1  sing N N 436 
TRP   CE2 CZ2  sing Y N 437 
TRP   CE3 CZ3  doub Y N 438 
TRP   CE3 HE3  sing N N 439 
TRP   CZ2 CH2  doub Y N 440 
TRP   CZ2 HZ2  sing N N 441 
TRP   CZ3 CH2  sing Y N 442 
TRP   CZ3 HZ3  sing N N 443 
TRP   CH2 HH2  sing N N 444 
TRP   OXT HXT  sing N N 445 
TYR   N   CA   sing N N 446 
TYR   N   H    sing N N 447 
TYR   N   H2   sing N N 448 
TYR   CA  C    sing N N 449 
TYR   CA  CB   sing N N 450 
TYR   CA  HA   sing N N 451 
TYR   C   O    doub N N 452 
TYR   C   OXT  sing N N 453 
TYR   CB  CG   sing N N 454 
TYR   CB  HB2  sing N N 455 
TYR   CB  HB3  sing N N 456 
TYR   CG  CD1  doub Y N 457 
TYR   CG  CD2  sing Y N 458 
TYR   CD1 CE1  sing Y N 459 
TYR   CD1 HD1  sing N N 460 
TYR   CD2 CE2  doub Y N 461 
TYR   CD2 HD2  sing N N 462 
TYR   CE1 CZ   doub Y N 463 
TYR   CE1 HE1  sing N N 464 
TYR   CE2 CZ   sing Y N 465 
TYR   CE2 HE2  sing N N 466 
TYR   CZ  OH   sing N N 467 
TYR   OH  HH   sing N N 468 
TYR   OXT HXT  sing N N 469 
VAL   N   CA   sing N N 470 
VAL   N   H    sing N N 471 
VAL   N   H2   sing N N 472 
VAL   CA  C    sing N N 473 
VAL   CA  CB   sing N N 474 
VAL   CA  HA   sing N N 475 
VAL   C   O    doub N N 476 
VAL   C   OXT  sing N N 477 
VAL   CB  CG1  sing N N 478 
VAL   CB  CG2  sing N N 479 
VAL   CB  HB   sing N N 480 
VAL   CG1 HG11 sing N N 481 
VAL   CG1 HG12 sing N N 482 
VAL   CG1 HG13 sing N N 483 
VAL   CG2 HG21 sing N N 484 
VAL   CG2 HG22 sing N N 485 
VAL   CG2 HG23 sing N N 486 
VAL   OXT HXT  sing N N 487 
# 
_pdbx_audit_support.funding_organization   'Other private' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   4OG3 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9C93 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.017681 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.011456 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.005129 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
F ? ? 4.90428  4.07044 ? ? 12.99538 1.63651  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
K ? ? 16.37977 2.54835 ? ? 4.54127  84.28225 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLY   A 1 20  ? -13.35773 -43.77753 -32.85260 1.000 49.94639 ? 2    GLY   A N   1 
ATOM   2    C CA  . GLY   A 1 20  ? -13.33818 -43.70515 -34.30299 1.000 54.53170 ? 2    GLY   A CA  1 
ATOM   3    C C   . GLY   A 1 20  ? -14.29288 -42.67590 -34.88288 1.000 47.00989 ? 2    GLY   A C   1 
ATOM   4    O O   . GLY   A 1 20  ? -15.33841 -42.38382 -34.29830 1.000 47.12662 ? 2    GLY   A O   1 
ATOM   5    N N   . LEU   A 1 21  ? -13.93360 -42.13212 -36.04484 1.000 48.62410 ? 3    LEU   A N   1 
ATOM   6    C CA  . LEU   A 1 21  ? -14.72439 -41.10048 -36.70585 1.000 44.68414 ? 3    LEU   A CA  1 
ATOM   7    C C   . LEU   A 1 21  ? -15.76560 -41.73388 -37.62187 1.000 50.57845 ? 3    LEU   A C   1 
ATOM   8    O O   . LEU   A 1 21  ? -15.45630 -42.66799 -38.36917 1.000 55.93738 ? 3    LEU   A O   1 
ATOM   9    C CB  . LEU   A 1 21  ? -13.82150 -40.16766 -37.51843 1.000 38.11607 ? 3    LEU   A CB  1 
ATOM   10   C CG  . LEU   A 1 21  ? -12.86831 -39.22530 -36.77245 1.000 33.43310 ? 3    LEU   A CG  1 
ATOM   11   C CD1 . LEU   A 1 21  ? -11.88730 -38.58523 -37.74556 1.000 30.99126 ? 3    LEU   A CD1 1 
ATOM   12   C CD2 . LEU   A 1 21  ? -13.64238 -38.16118 -36.01695 1.000 32.49068 ? 3    LEU   A CD2 1 
ATOM   13   N N   . LYS   A 1 22  ? -16.99448 -41.21775 -37.56322 1.000 48.84998 ? 4    LYS   A N   1 
ATOM   14   C CA  . LYS   A 1 22  ? -18.02817 -41.59913 -38.51804 1.000 40.81970 ? 4    LYS   A CA  1 
ATOM   15   C C   . LYS   A 1 22  ? -17.52513 -41.40967 -39.94329 1.000 40.40028 ? 4    LYS   A C   1 
ATOM   16   O O   . LYS   A 1 22  ? -16.66057 -40.57258 -40.21186 1.000 41.31033 ? 4    LYS   A O   1 
ATOM   17   C CB  . LYS   A 1 22  ? -19.29518 -40.76105 -38.30751 1.000 48.15616 ? 4    LYS   A CB  1 
ATOM   18   C CG  . LYS   A 1 22  ? -19.72452 -40.56616 -36.85614 1.000 52.87649 ? 4    LYS   A CG  1 
ATOM   19   C CD  . LYS   A 1 22  ? -20.35349 -41.82824 -36.27797 1.000 54.02558 ? 4    LYS   A CD  1 
ATOM   20   C CE  . LYS   A 1 22  ? -20.41177 -41.77477 -34.75618 1.000 61.58019 ? 4    LYS   A CE  1 
ATOM   21   N NZ  . LYS   A 1 22  ? -20.84916 -40.43569 -34.26161 1.000 55.30303 ? 4    LYS   A NZ  1 
ATOM   22   N N   . THR   A 1 23  ? -18.07187 -42.20049 -40.86968 1.000 46.69844 ? 5    THR   A N   1 
ATOM   23   C CA  . THR   A 1 23  ? -17.62942 -42.09735 -42.25653 1.000 40.26773 ? 5    THR   A CA  1 
ATOM   24   C C   . THR   A 1 23  ? -18.11581 -40.80503 -42.90004 1.000 32.32656 ? 5    THR   A C   1 
ATOM   25   O O   . THR   A 1 23  ? -17.46587 -40.28341 -43.81509 1.000 39.05235 ? 5    THR   A O   1 
ATOM   26   C CB  . THR   A 1 23  ? -18.10625 -43.31055 -43.06159 1.000 54.44622 ? 5    THR   A CB  1 
ATOM   27   O OG1 . THR   A 1 23  ? -19.43340 -43.07524 -43.54187 1.000 47.13996 ? 5    THR   A OG1 1 
ATOM   28   C CG2 . THR   A 1 23  ? -18.10676 -44.56852 -42.19313 1.000 40.82670 ? 5    THR   A CG2 1 
ATOM   29   N N   . ALA   A 1 24  ? -19.25027 -40.27471 -42.43741 1.000 38.04681 ? 6    ALA   A N   1 
ATOM   30   C CA  . ALA   A 1 24  ? -19.71243 -38.98187 -42.92839 1.000 42.27193 ? 6    ALA   A CA  1 
ATOM   31   C C   . ALA   A 1 24  ? -18.73031 -37.87358 -42.57541 1.000 40.64976 ? 6    ALA   A C   1 
ATOM   32   O O   . ALA   A 1 24  ? -18.57236 -36.91469 -43.34077 1.000 39.54521 ? 6    ALA   A O   1 
ATOM   33   C CB  . ALA   A 1 24  ? -21.09895 -38.66973 -42.36216 1.000 34.70122 ? 6    ALA   A CB  1 
ATOM   34   N N   . GLN   A 1 25  ? -18.05849 -37.98942 -41.42714 1.000 37.71005 ? 7    GLN   A N   1 
ATOM   35   C CA  . GLN   A 1 25  ? -17.05141 -37.00072 -41.05393 1.000 33.55072 ? 7    GLN   A CA  1 
ATOM   36   C C   . GLN   A 1 25  ? -15.79932 -37.14657 -41.91004 1.000 39.45204 ? 7    GLN   A C   1 
ATOM   37   O O   . GLN   A 1 25  ? -15.25362 -36.15326 -42.40471 1.000 38.36155 ? 7    GLN   A O   1 
ATOM   38   C CB  . GLN   A 1 25  ? -16.71506 -37.13567 -39.56589 1.000 34.34013 ? 7    GLN   A CB  1 
ATOM   39   C CG  . GLN   A 1 25  ? -17.94837 -37.22720 -38.66493 1.000 41.69617 ? 7    GLN   A CG  1 
ATOM   40   C CD  . GLN   A 1 25  ? -17.61278 -37.19551 -37.18556 1.000 39.57704 ? 7    GLN   A CD  1 
ATOM   41   O OE1 . GLN   A 1 25  ? -16.82780 -38.00885 -36.69927 1.000 50.39890 ? 7    GLN   A OE1 1 
ATOM   42   N NE2 . GLN   A 1 25  ? -18.23122 -36.27520 -36.45687 1.000 37.54918 ? 7    GLN   A NE2 1 
ATOM   43   N N   . LYS   A 1 26  ? -15.33838 -38.38552 -42.10936 1.000 31.24411 ? 8    LYS   A N   1 
ATOM   44   C CA  . LYS   A 1 26  ? -14.09510 -38.60351 -42.83820 1.000 37.39194 ? 8    LYS   A CA  1 
ATOM   45   C C   . LYS   A 1 26  ? -14.20833 -38.18823 -44.29855 1.000 33.21349 ? 8    LYS   A C   1 
ATOM   46   O O   . LYS   A 1 26  ? -13.22099 -37.72846 -44.88606 1.000 33.84536 ? 8    LYS   A O   1 
ATOM   47   C CB  . LYS   A 1 26  ? -13.67112 -40.06852 -42.72089 1.000 38.16378 ? 8    LYS   A CB  1 
ATOM   48   C CG  . LYS   A 1 26  ? -13.26974 -40.46467 -41.30340 1.000 40.96040 ? 8    LYS   A CG  1 
ATOM   49   C CD  . LYS   A 1 26  ? -13.73701 -41.86254 -40.94821 1.000 43.81751 ? 8    LYS   A CD  1 
ATOM   50   C CE  . LYS   A 1 26  ? -13.36857 -42.85732 -42.02748 1.000 35.32245 ? 8    LYS   A CE  1 
ATOM   51   N NZ  . LYS   A 1 26  ? -13.60592 -44.24142 -41.55527 1.000 44.90544 ? 8    LYS   A NZ  1 
ATOM   52   N N   . THR   A 1 27  ? -15.39592 -38.31847 -44.89591 1.000 44.40597 ? 9    THR   A N   1 
ATOM   53   C CA  . THR   A 1 27  ? -15.55597 -37.97449 -46.30570 1.000 40.74420 ? 9    THR   A CA  1 
ATOM   54   C C   . THR   A 1 27  ? -15.28536 -36.49984 -46.58122 1.000 40.99947 ? 9    THR   A C   1 
ATOM   55   O O   . THR   A 1 27  ? -15.05575 -36.12734 -47.73791 1.000 33.55354 ? 9    THR   A O   1 
ATOM   56   C CB  . THR   A 1 27  ? -16.96397 -38.34832 -46.78690 1.000 38.43439 ? 9    THR   A CB  1 
ATOM   57   O OG1 . THR   A 1 27  ? -16.94242 -38.57274 -48.20130 1.000 44.96952 ? 9    THR   A OG1 1 
ATOM   58   C CG2 . THR   A 1 27  ? -17.96029 -37.23999 -46.47234 1.000 42.14647 ? 9    THR   A CG2 1 
ATOM   59   N N   . LEU   A 1 28  ? -15.29279 -35.65510 -45.54980 1.000 43.06071 ? 10   LEU   A N   1 
ATOM   60   C CA  . LEU   A 1 28  ? -15.08263 -34.22616 -45.73818 1.000 39.25908 ? 10   LEU   A CA  1 
ATOM   61   C C   . LEU   A 1 28  ? -13.60736 -33.84203 -45.82246 1.000 38.24547 ? 10   LEU   A C   1 
ATOM   62   O O   . LEU   A 1 28  ? -13.29988 -32.70815 -46.20615 1.000 38.80772 ? 10   LEU   A O   1 
ATOM   63   C CB  . LEU   A 1 28  ? -15.77014 -33.45939 -44.60281 1.000 37.63899 ? 10   LEU   A CB  1 
ATOM   64   C CG  . LEU   A 1 28  ? -17.29921 -33.57536 -44.63209 1.000 46.99375 ? 10   LEU   A CG  1 
ATOM   65   C CD1 . LEU   A 1 28  ? -17.93187 -33.17450 -43.30565 1.000 32.46650 ? 10   LEU   A CD1 1 
ATOM   66   C CD2 . LEU   A 1 28  ? -17.86508 -32.73928 -45.76848 1.000 45.20373 ? 10   LEU   A CD2 1 
ATOM   67   N N   . PHE   A 1 29  ? -12.69164 -34.75365 -45.49068 1.000 27.81376 ? 11   PHE   A N   1 
ATOM   68   C CA  . PHE   A 1 29  ? -11.25757 -34.50337 -45.52077 1.000 34.76627 ? 11   PHE   A CA  1 
ATOM   69   C C   . PHE   A 1 29  ? -10.68719 -34.83646 -46.89574 1.000 33.90960 ? 11   PHE   A C   1 
ATOM   70   O O   . PHE   A 1 29  ? -11.31395 -35.55552 -47.68066 1.000 40.76014 ? 11   PHE   A O   1 
ATOM   71   C CB  . PHE   A 1 29  ? -10.57260 -35.33046 -44.43216 1.000 23.06017 ? 11   PHE   A CB  1 
ATOM   72   C CG  . PHE   A 1 29  ? -10.78553 -34.78964 -43.04255 1.000 26.28654 ? 11   PHE   A CG  1 
ATOM   73   C CD1 . PHE   A 1 29  ? -9.90817  -33.86479 -42.49440 1.000 29.48050 ? 11   PHE   A CD1 1 
ATOM   74   C CD2 . PHE   A 1 29  ? -11.89410 -35.17838 -42.30130 1.000 24.03384 ? 11   PHE   A CD2 1 
ATOM   75   C CE1 . PHE   A 1 29  ? -10.11177 -33.36169 -41.21118 1.000 25.48827 ? 11   PHE   A CE1 1 
ATOM   76   C CE2 . PHE   A 1 29  ? -12.11172 -34.67954 -41.02347 1.000 28.43341 ? 11   PHE   A CE2 1 
ATOM   77   C CZ  . PHE   A 1 29  ? -11.21958 -33.76828 -40.47705 1.000 22.57706 ? 11   PHE   A CZ  1 
ATOM   78   N N   . PRO   A 1 30  ? -9.51323  -34.28816 -47.25323 1.000 32.16327 ? 12   PRO   A N   1 
ATOM   79   C CA  . PRO   A 1 30  ? -8.67940  -33.35193 -46.49481 1.000 28.65234 ? 12   PRO   A CA  1 
ATOM   80   C C   . PRO   A 1 30  ? -9.26181  -31.95120 -46.51813 1.000 37.43303 ? 12   PRO   A C   1 
ATOM   81   O O   . PRO   A 1 30  ? -9.92695  -31.58108 -47.48019 1.000 33.36533 ? 12   PRO   A O   1 
ATOM   82   C CB  . PRO   A 1 30  ? -7.33185  -33.40083 -47.22695 1.000 35.78787 ? 12   PRO   A CB  1 
ATOM   83   C CG  . PRO   A 1 30  ? -7.62541  -33.93229 -48.61607 1.000 28.37086 ? 12   PRO   A CG  1 
ATOM   84   C CD  . PRO   A 1 30  ? -9.03796  -34.44670 -48.63919 1.000 29.29453 ? 12   PRO   A CD  1 
ATOM   85   N N   . LEU   A 1 31  ? -9.02942  -31.15564 -45.47801 1.000 27.14089 ? 13   LEU   A N   1 
ATOM   86   C CA  . LEU   A 1 31  ? -9.42443  -29.75527 -45.47223 1.000 20.88129 ? 13   LEU   A CA  1 
ATOM   87   C C   . LEU   A 1 31  ? -8.30851  -28.94098 -46.10737 1.000 22.12433 ? 13   LEU   A C   1 
ATOM   88   O O   . LEU   A 1 31  ? -7.18749  -28.90107 -45.58705 1.000 24.19734 ? 13   LEU   A O   1 
ATOM   89   C CB  . LEU   A 1 31  ? -9.70073  -29.27187 -44.05076 1.000 21.12570 ? 13   LEU   A CB  1 
ATOM   90   C CG  . LEU   A 1 31  ? -10.56554 -30.19957 -43.20593 1.000 20.46806 ? 13   LEU   A CG  1 
ATOM   91   C CD1 . LEU   A 1 31  ? -10.59726 -29.70356 -41.76835 1.000 22.42963 ? 13   LEU   A CD1 1 
ATOM   92   C CD2 . LEU   A 1 31  ? -11.97666 -30.36256 -43.77470 1.000 26.03343 ? 13   LEU   A CD2 1 
ATOM   93   N N   . ARG   A 1 32  ? -8.60777  -28.29864 -47.23112 1.000 24.41848 ? 14   ARG   A N   1 
ATOM   94   C CA  . ARG   A 1 32  ? -7.61305  -27.53359 -47.96347 1.000 21.02211 ? 14   ARG   A CA  1 
ATOM   95   C C   . ARG   A 1 32  ? -7.89437  -26.04178 -47.96418 1.000 23.48052 ? 14   ARG   A C   1 
ATOM   96   O O   . ARG   A 1 32  ? -7.11636  -25.27831 -48.54643 1.000 22.48190 ? 14   ARG   A O   1 
ATOM   97   C CB  . ARG   A 1 32  ? -7.52513  -28.03745 -49.40708 1.000 33.28202 ? 14   ARG   A CB  1 
ATOM   98   C CG  . ARG   A 1 32  ? -7.11295  -29.48929 -49.50597 1.000 33.91928 ? 14   ARG   A CG  1 
ATOM   99   C CD  . ARG   A 1 32  ? -6.74076  -29.86730 -50.92403 1.000 42.56631 ? 14   ARG   A CD  1 
ATOM   100  N NE  . ARG   A 1 32  ? -5.43155  -30.50547 -50.96522 1.000 59.29266 ? 14   ARG   A NE  1 
ATOM   101  C CZ  . ARG   A 1 32  ? -5.21488  -31.73345 -51.41383 1.000 52.24396 ? 14   ARG   A CZ  1 
ATOM   102  N NH1 . ARG   A 1 32  ? -6.20320  -32.48392 -51.87672 1.000 38.41131 ? 14   ARG   A NH1 1 
ATOM   103  N NH2 . ARG   A 1 32  ? -3.97782  -32.22304 -51.38965 1.000 54.53731 ? 14   ARG   A NH2 1 
ATOM   104  N N   . SER   A 1 33  ? -8.97091  -25.60132 -47.32135 1.000 23.76072 ? 15   SER   A N   1 
ATOM   105  C CA  . SER   A 1 33  ? -9.32398  -24.18991 -47.34605 1.000 27.77686 ? 15   SER   A CA  1 
ATOM   106  C C   . SER   A 1 33  ? -10.15850 -23.87014 -46.11841 1.000 18.24627 ? 15   SER   A C   1 
ATOM   107  O O   . SER   A 1 33  ? -10.64167 -24.75965 -45.41453 1.000 23.48794 ? 15   SER   A O   1 
ATOM   108  C CB  . SER   A 1 33  ? -10.11045 -23.83338 -48.61070 1.000 17.86632 ? 15   SER   A CB  1 
ATOM   109  O OG  . SER   A 1 33  ? -11.28574 -24.62977 -48.66780 1.000 22.71270 ? 15   SER   A OG  1 
ATOM   110  N N   . ILE   A 1 34  ? -10.33001 -22.57122 -45.88575 1.000 25.00839 ? 16   ILE   A N   1 
ATOM   111  C CA  . ILE   A 1 34  ? -11.29296 -22.10223 -44.89383 1.000 19.97326 ? 16   ILE   A CA  1 
ATOM   112  C C   . ILE   A 1 34  ? -12.68055 -22.67600 -45.18229 1.000 26.34551 ? 16   ILE   A C   1 
ATOM   113  O O   . ILE   A 1 34  ? -13.36439 -23.17478 -44.28000 1.000 21.17002 ? 16   ILE   A O   1 
ATOM   114  C CB  . ILE   A 1 34  ? -11.29030 -20.56185 -44.85792 1.000 24.26837 ? 16   ILE   A CB  1 
ATOM   115  C CG1 . ILE   A 1 34  ? -9.94752  -20.07792 -44.28382 1.000 22.10850 ? 16   ILE   A CG1 1 
ATOM   116  C CG2 . ILE   A 1 34  ? -12.50485 -20.01404 -44.09715 1.000 20.09600 ? 16   ILE   A CG2 1 
ATOM   117  C CD1 . ILE   A 1 34  ? -9.72281  -18.56694 -44.31124 1.000 23.53551 ? 16   ILE   A CD1 1 
ATOM   118  N N   . ASP   A 1 35  ? -13.10647 -22.64461 -46.45418 1.000 27.59276 ? 17   ASP   A N   1 
ATOM   119  C CA  . ASP   A 1 35  ? -14.44596 -23.12836 -46.78895 1.000 23.96178 ? 17   ASP   A CA  1 
ATOM   120  C C   . ASP   A 1 35  ? -14.61424 -24.59384 -46.43050 1.000 18.74415 ? 17   ASP   A C   1 
ATOM   121  O O   . ASP   A 1 35  ? -15.67802 -24.99993 -45.95057 1.000 23.37231 ? 17   ASP   A O   1 
ATOM   122  C CB  . ASP   A 1 35  ? -14.74981 -22.92688 -48.27234 1.000 27.96721 ? 17   ASP   A CB  1 
ATOM   123  C CG  . ASP   A 1 35  ? -14.86918 -21.47298 -48.65283 1.000 39.54241 ? 17   ASP   A CG  1 
ATOM   124  O OD1 . ASP   A 1 35  ? -14.95383 -20.61007 -47.74589 1.000 40.47542 ? 17   ASP   A OD1 1 
ATOM   125  O OD2 . ASP   A 1 35  ? -14.88702 -21.20330 -49.87181 1.000 46.20847 ? 17   ASP   A OD2 1 
ATOM   126  N N   . ASP   A 1 36  ? -13.58091 -25.40659 -46.67470 1.000 20.67496 ? 18   ASP   A N   1 
ATOM   127  C CA  . ASP   A 1 36  ? -13.60278 -26.79370 -46.22430 1.000 24.20485 ? 18   ASP   A CA  1 
ATOM   128  C C   . ASP   A 1 36  ? -13.86483 -26.88265 -44.72967 1.000 15.46750 ? 18   ASP   A C   1 
ATOM   129  O O   . ASP   A 1 36  ? -14.67122 -27.70448 -44.28178 1.000 20.71457 ? 18   ASP   A O   1 
ATOM   130  C CB  . ASP   A 1 36  ? -12.28134 -27.47658 -46.59304 1.000 25.14736 ? 18   ASP   A CB  1 
ATOM   131  C CG  . ASP   A 1 36  ? -12.20932 -27.85987 -48.06687 1.000 37.67012 ? 18   ASP   A CG  1 
ATOM   132  O OD1 . ASP   A 1 36  ? -13.24003 -27.74413 -48.76543 1.000 28.39011 ? 18   ASP   A OD1 1 
ATOM   133  O OD2 . ASP   A 1 36  ? -11.10716 -28.19874 -48.54394 1.000 28.93092 ? 18   ASP   A OD2 1 
ATOM   134  N N   . VAL   A 1 37  ? -13.19751 -26.03730 -43.94134 1.000 22.57729 ? 19   VAL   A N   1 
ATOM   135  C CA  . VAL   A 1 37  ? -13.42235 -26.04376 -42.49640 1.000 19.69039 ? 19   VAL   A CA  1 
ATOM   136  C C   . VAL   A 1 37  ? -14.86446 -25.66649 -42.19052 1.000 15.93055 ? 19   VAL   A C   1 
ATOM   137  O O   . VAL   A 1 37  ? -15.54127 -26.32037 -41.38709 1.000 19.95476 ? 19   VAL   A O   1 
ATOM   138  C CB  . VAL   A 1 37  ? -12.42760 -25.10519 -41.78800 1.000 21.87902 ? 19   VAL   A CB  1 
ATOM   139  C CG1 . VAL   A 1 37  ? -12.72543 -25.04760 -40.28924 1.000 19.51312 ? 19   VAL   A CG1 1 
ATOM   140  C CG2 . VAL   A 1 37  ? -10.98413 -25.56955 -42.02955 1.000 18.02166 ? 19   VAL   A CG2 1 
ATOM   141  N N   . VAL   A 1 38  ? -15.36382 -24.61813 -42.84841 1.000 21.07649 ? 20   VAL   A N   1 
ATOM   142  C CA  . VAL   A 1 38  ? -16.73953 -24.18682 -42.61055 1.000 19.40815 ? 20   VAL   A CA  1 
ATOM   143  C C   . VAL   A 1 38  ? -17.71986 -25.31672 -42.90890 1.000 20.75707 ? 20   VAL   A C   1 
ATOM   144  O O   . VAL   A 1 38  ? -18.67498 -25.53291 -42.15378 1.000 25.19860 ? 20   VAL   A O   1 
ATOM   145  C CB  . VAL   A 1 38  ? -17.06111 -22.91908 -43.42419 1.000 20.99093 ? 20   VAL   A CB  1 
ATOM   146  C CG1 . VAL   A 1 38  ? -18.47610 -22.45064 -43.13124 1.000 23.16487 ? 20   VAL   A CG1 1 
ATOM   147  C CG2 . VAL   A 1 38  ? -16.07021 -21.81455 -43.10812 1.000 20.73326 ? 20   VAL   A CG2 1 
ATOM   148  N N   . ARG   A 1 39  ? -17.48709 -26.08523 -43.98595 1.000 24.18192 ? 21   ARG   A N   1 
ATOM   149  C CA  . ARG   A 1 39  ? -18.40246 -27.19273 -44.26753 1.000 24.30737 ? 21   ARG   A CA  1 
ATOM   150  C C   . ARG   A 1 39  ? -18.32764 -28.26047 -43.19049 1.000 27.74045 ? 21   ARG   A C   1 
ATOM   151  O O   . ARG   A 1 39  ? -19.35775 -28.83132 -42.81188 1.000 19.48370 ? 21   ARG   A O   1 
ATOM   152  C CB  . ARG   A 1 39  ? -18.14552 -27.84031 -45.63264 1.000 33.73935 ? 21   ARG   A CB  1 
ATOM   153  C CG  . ARG   A 1 39  ? -17.99970 -26.90888 -46.81800 1.000 39.03211 ? 21   ARG   A CG  1 
ATOM   154  C CD  . ARG   A 1 39  ? -17.68115 -27.72269 -48.07286 1.000 35.11413 ? 21   ARG   A CD  1 
ATOM   155  N NE  . ARG   A 1 39  ? -16.45284 -27.27538 -48.72020 1.000 48.59377 ? 21   ARG   A NE  1 
ATOM   156  C CZ  . ARG   A 1 39  ? -16.35306 -26.21113 -49.50569 1.000 38.84845 ? 21   ARG   A CZ  1 
ATOM   157  N NH1 . ARG   A 1 39  ? -17.39522 -25.43117 -49.75164 1.000 42.12659 ? 21   ARG   A NH1 1 
ATOM   158  N NH2 . ARG   A 1 39  ? -15.17540 -25.91777 -50.05332 1.000 42.14020 ? 21   ARG   A NH2 1 
ATOM   159  N N   . LEU   A 1 40  ? -17.12430 -28.56400 -42.69065 1.000 19.00116 ? 22   LEU   A N   1 
ATOM   160  C CA  . LEU   A 1 40  ? -17.05074 -29.51387 -41.58619 1.000 26.21217 ? 22   LEU   A CA  1 
ATOM   161  C C   . LEU   A 1 40  ? -17.85328 -29.01092 -40.39359 1.000 23.12565 ? 22   LEU   A C   1 
ATOM   162  O O   . LEU   A 1 40  ? -18.59212 -29.77783 -39.76169 1.000 23.23957 ? 22   LEU   A O   1 
ATOM   163  C CB  . LEU   A 1 40  ? -15.59618 -29.78372 -41.18570 1.000 21.99531 ? 22   LEU   A CB  1 
ATOM   164  C CG  . LEU   A 1 40  ? -15.47890 -30.67320 -39.94057 1.000 27.64354 ? 22   LEU   A CG  1 
ATOM   165  C CD1 . LEU   A 1 40  ? -16.02714 -32.06729 -40.22360 1.000 29.50100 ? 22   LEU   A CD1 1 
ATOM   166  C CD2 . LEU   A 1 40  ? -14.03538 -30.76311 -39.43475 1.000 24.55603 ? 22   LEU   A CD2 1 
ATOM   167  N N   . PHE   A 1 41  ? -17.74033 -27.71516 -40.08628 1.000 20.12848 ? 23   PHE   A N   1 
ATOM   168  C CA  . PHE   A 1 41  ? -18.51692 -27.16140 -38.98392 1.000 17.37677 ? 23   PHE   A CA  1 
ATOM   169  C C   . PHE   A 1 41  ? -20.00961 -27.19018 -39.28841 1.000 23.93607 ? 23   PHE   A C   1 
ATOM   170  O O   . PHE   A 1 41  ? -20.81818 -27.52606 -38.41583 1.000 23.34224 ? 23   PHE   A O   1 
ATOM   171  C CB  . PHE   A 1 41  ? -18.04550 -25.74008 -38.67303 1.000 18.71832 ? 23   PHE   A CB  1 
ATOM   172  C CG  . PHE   A 1 41  ? -16.93692 -25.69281 -37.65961 1.000 16.17880 ? 23   PHE   A CG  1 
ATOM   173  C CD1 . PHE   A 1 41  ? -15.62812 -25.94138 -38.03723 1.000 18.55162 ? 23   PHE   A CD1 1 
ATOM   174  C CD2 . PHE   A 1 41  ? -17.21361 -25.45329 -36.32050 1.000 18.06152 ? 23   PHE   A CD2 1 
ATOM   175  C CE1 . PHE   A 1 41  ? -14.60422 -25.91449 -37.10849 1.000 18.63003 ? 23   PHE   A CE1 1 
ATOM   176  C CE2 . PHE   A 1 41  ? -16.18511 -25.42580 -35.37515 1.000 15.19946 ? 23   PHE   A CE2 1 
ATOM   177  C CZ  . PHE   A 1 41  ? -14.88241 -25.66600 -35.77604 1.000 14.79352 ? 23   PHE   A CZ  1 
ATOM   178  N N   . ALA   A 1 42  ? -20.39588 -26.84050 -40.51799 1.000 23.40176 ? 24   ALA   A N   1 
ATOM   179  C CA  . ALA   A 1 42  ? -21.80534 -26.91645 -40.89156 1.000 21.30528 ? 24   ALA   A CA  1 
ATOM   180  C C   . ALA   A 1 42  ? -22.34613 -28.33541 -40.74298 1.000 26.03903 ? 24   ALA   A C   1 
ATOM   181  O O   . ALA   A 1 42  ? -23.45065 -28.53789 -40.22412 1.000 24.95946 ? 24   ALA   A O   1 
ATOM   182  C CB  . ALA   A 1 42  ? -21.98912 -26.40972 -42.32128 1.000 24.13925 ? 24   ALA   A CB  1 
ATOM   183  N N   . ALA   A 1 43  ? -21.57521 -29.33440 -41.17321 1.000 23.04455 ? 25   ALA   A N   1 
ATOM   184  C CA  . ALA   A 1 43  ? -22.03857 -30.71207 -41.06314 1.000 21.37397 ? 25   ALA   A CA  1 
ATOM   185  C C   . ALA   A 1 43  ? -22.22186 -31.11211 -39.60703 1.000 27.16304 ? 25   ALA   A C   1 
ATOM   186  O O   . ALA   A 1 43  ? -23.24719 -31.69570 -39.23497 1.000 24.66292 ? 25   ALA   A O   1 
ATOM   187  C CB  . ALA   A 1 43  ? -21.05773 -31.65183 -41.76667 1.000 25.19229 ? 25   ALA   A CB  1 
ATOM   188  N N   . GLU   A 1 44  ? -21.23359 -30.79710 -38.76235 1.000 22.97164 ? 26   GLU   A N   1 
ATOM   189  C CA  . GLU   A 1 44  ? -21.31388 -31.18009 -37.35852 1.000 23.47525 ? 26   GLU   A CA  1 
ATOM   190  C C   . GLU   A 1 44  ? -22.48318 -30.50026 -36.65982 1.000 20.48464 ? 26   GLU   A C   1 
ATOM   191  O O   . GLU   A 1 44  ? -23.18215 -31.12928 -35.85798 1.000 23.10334 ? 26   GLU   A O   1 
ATOM   192  C CB  . GLU   A 1 44  ? -20.00259 -30.85081 -36.64886 1.000 20.51358 ? 26   GLU   A CB  1 
ATOM   193  C CG  . GLU   A 1 44  ? -18.89513 -31.85161 -36.93403 1.000 20.72226 ? 26   GLU   A CG  1 
ATOM   194  C CD  . GLU   A 1 44  ? -19.32204 -33.27472 -36.65341 1.000 30.50031 ? 26   GLU   A CD  1 
ATOM   195  O OE1 . GLU   A 1 44  ? -19.63424 -33.58752 -35.48054 1.000 22.98195 ? 26   GLU   A OE1 1 
ATOM   196  O OE2 . GLU   A 1 44  ? -19.34253 -34.08079 -37.60728 1.000 34.09462 ? 26   GLU   A OE2 1 
ATOM   197  N N   . LEU   A 1 45  ? -22.71353 -29.21643 -36.94898 1.000 20.53161 ? 27   LEU   A N   1 
ATOM   198  C CA  . LEU   A 1 45  ? -23.77718 -28.48177 -36.27083 1.000 22.71457 ? 27   LEU   A CA  1 
ATOM   199  C C   . LEU   A 1 45  ? -25.16602 -28.95134 -36.67912 1.000 33.13626 ? 27   LEU   A C   1 
ATOM   200  O O   . LEU   A 1 45  ? -26.14457 -28.61928 -35.99855 1.000 21.60819 ? 27   LEU   A O   1 
ATOM   201  C CB  . LEU   A 1 45  ? -23.63772 -26.97913 -36.53304 1.000 25.78045 ? 27   LEU   A CB  1 
ATOM   202  C CG  . LEU   A 1 45  ? -22.50636 -26.27111 -35.77971 1.000 23.43510 ? 27   LEU   A CG  1 
ATOM   203  C CD1 . LEU   A 1 45  ? -22.16906 -24.96497 -36.46098 1.000 20.90941 ? 27   LEU   A CD1 1 
ATOM   204  C CD2 . LEU   A 1 45  ? -22.88019 -26.03672 -34.30985 1.000 20.78442 ? 27   LEU   A CD2 1 
ATOM   205  N N   . GLY   A 1 46  ? -25.27460 -29.70772 -37.76709 1.000 35.03606 ? 28   GLY   A N   1 
ATOM   206  C CA  . GLY   A 1 46  ? -26.52914 -30.32926 -38.11788 1.000 29.53352 ? 28   GLY   A CA  1 
ATOM   207  C C   . GLY   A 1 46  ? -26.87334 -31.56613 -37.32329 1.000 42.32849 ? 28   GLY   A C   1 
ATOM   208  O O   . GLY   A 1 46  ? -27.96579 -32.11270 -37.50234 1.000 39.46428 ? 28   GLY   A O   1 
ATOM   209  N N   . ARG   A 1 47  ? -25.97893 -32.03173 -36.45264 1.000 26.48598 ? 29   ARG   A N   1 
ATOM   210  C CA  . ARG   A 1 47  ? -26.23911 -33.20497 -35.63233 1.000 34.10747 ? 29   ARG   A CA  1 
ATOM   211  C C   . ARG   A 1 47  ? -26.56395 -32.79067 -34.20200 1.000 29.24855 ? 29   ARG   A C   1 
ATOM   212  O O   . ARG   A 1 47  ? -26.30612 -31.66065 -33.77680 1.000 34.08428 ? 29   ARG   A O   1 
ATOM   213  C CB  . ARG   A 1 47  ? -25.04437 -34.17271 -35.65008 1.000 39.35755 ? 29   ARG   A CB  1 
ATOM   214  C CG  . ARG   A 1 47  ? -24.19025 -34.09061 -36.91801 1.000 40.91441 ? 29   ARG   A CG  1 
ATOM   215  C CD  . ARG   A 1 47  ? -23.35761 -35.35096 -37.15841 1.000 51.98185 ? 29   ARG   A CD  1 
ATOM   216  N NE  . ARG   A 1 47  ? -22.15311 -35.39450 -36.33811 1.000 43.98636 ? 29   ARG   A NE  1 
ATOM   217  C CZ  . ARG   A 1 47  ? -22.02671 -36.10347 -35.22285 1.000 55.57556 ? 29   ARG   A CZ  1 
ATOM   218  N NH1 . ARG   A 1 47  ? -22.99656 -36.89756 -34.79412 1.000 47.91472 ? 29   ARG   A NH1 1 
ATOM   219  N NH2 . ARG   A 1 47  ? -20.89590 -36.01759 -34.52207 1.000 36.45113 ? 29   ARG   A NH2 1 
ATOM   220  N N   . GLU   A 1 48  ? -27.14283 -33.73126 -33.45601 1.000 30.70745 ? 30   GLU   A N   1 
ATOM   221  C CA  . GLU   A 1 48  ? -27.51863 -33.43942 -32.07828 1.000 36.30974 ? 30   GLU   A CA  1 
ATOM   222  C C   . GLU   A 1 48  ? -26.29922 -33.32496 -31.17412 1.000 45.61690 ? 30   GLU   A C   1 
ATOM   223  O O   . GLU   A 1 48  ? -26.35586 -32.65016 -30.13863 1.000 40.06089 ? 30   GLU   A O   1 
ATOM   224  C CB  . GLU   A 1 48  ? -28.47281 -34.51298 -31.55904 1.000 45.00736 ? 30   GLU   A CB  1 
ATOM   225  C CG  . GLU   A 1 48  ? -29.93676 -34.11112 -31.63982 1.000 57.96414 ? 30   GLU   A CG  1 
ATOM   226  C CD  . GLU   A 1 48  ? -30.86834 -35.19320 -31.12889 1.000 71.69621 ? 30   GLU   A CD  1 
ATOM   227  O OE1 . GLU   A 1 48  ? -32.02960 -35.24543 -31.59389 1.000 73.05572 ? 30   GLU   A OE1 1 
ATOM   228  O OE2 . GLU   A 1 48  ? -30.44030 -35.98897 -30.26361 1.000 66.72793 ? 30   GLU   A OE2 1 
ATOM   229  N N   . GLU   A 1 49  ? -25.19381 -33.96857 -31.53955 1.000 34.32804 ? 31   GLU   A N   1 
ATOM   230  C CA  . GLU   A 1 49  ? -23.94640 -33.88126 -30.78381 1.000 38.20423 ? 31   GLU   A CA  1 
ATOM   231  C C   . GLU   A 1 49  ? -22.80798 -33.53923 -31.73576 1.000 33.67623 ? 31   GLU   A C   1 
ATOM   232  O O   . GLU   A 1 49  ? -22.08276 -34.42953 -32.20309 1.000 29.31168 ? 31   GLU   A O   1 
ATOM   233  C CB  . GLU   A 1 49  ? -23.66707 -35.18027 -30.02463 1.000 39.63004 ? 31   GLU   A CB  1 
ATOM   234  C CG  . GLU   A 1 49  ? -24.70386 -35.50547 -28.96134 1.000 36.10959 ? 31   GLU   A CG  1 
ATOM   235  C CD  . GLU   A 1 49  ? -24.40501 -34.83006 -27.62898 1.000 41.32545 ? 31   GLU   A CD  1 
ATOM   236  O OE1 . GLU   A 1 49  ? -23.21497 -34.69991 -27.27617 1.000 35.08955 ? 31   GLU   A OE1 1 
ATOM   237  O OE2 . GLU   A 1 49  ? -25.36350 -34.44009 -26.92957 1.000 46.19055 ? 31   GLU   A OE2 1 
ATOM   238  N N   . PRO   A 1 50  ? -22.62323 -32.25568 -32.04992 1.000 31.63460 ? 32   PRO   A N   1 
ATOM   239  C CA  . PRO   A 1 50  ? -21.42637 -31.85672 -32.80250 1.000 22.02521 ? 32   PRO   A CA  1 
ATOM   240  C C   . PRO   A 1 50  ? -20.18379 -32.29788 -32.04717 1.000 22.81957 ? 32   PRO   A C   1 
ATOM   241  O O   . PRO   A 1 50  ? -20.10025 -32.16043 -30.82445 1.000 22.89413 ? 32   PRO   A O   1 
ATOM   242  C CB  . PRO   A 1 50  ? -21.52651 -30.32596 -32.88590 1.000 31.45804 ? 32   PRO   A CB  1 
ATOM   243  C CG  . PRO   A 1 50  ? -22.77580 -29.92803 -32.18998 1.000 29.83467 ? 32   PRO   A CG  1 
ATOM   244  C CD  . PRO   A 1 50  ? -23.41717 -31.11492 -31.55833 1.000 33.83643 ? 32   PRO   A CD  1 
ATOM   245  N N   . ASP   A 1 51  ? -19.23274 -32.87408 -32.77861 1.000 25.25260 ? 33   ASP   A N   1 
ATOM   246  C CA  . ASP   A 1 51  ? -18.06449 -33.50287 -32.15784 1.000 26.68861 ? 33   ASP   A CA  1 
ATOM   247  C C   . ASP   A 1 51  ? -17.09681 -32.41499 -31.69711 1.000 16.95765 ? 33   ASP   A C   1 
ATOM   248  O O   . ASP   A 1 51  ? -16.27714 -31.93095 -32.47549 1.000 15.76137 ? 33   ASP   A O   1 
ATOM   249  C CB  . ASP   A 1 51  ? -17.39751 -34.47004 -33.13206 1.000 20.71273 ? 33   ASP   A CB  1 
ATOM   250  C CG  . ASP   A 1 51  ? -16.46155 -35.44815 -32.44067 1.000 26.45305 ? 33   ASP   A CG  1 
ATOM   251  O OD1 . ASP   A 1 51  ? -15.71627 -35.02890 -31.52827 1.000 21.12379 ? 33   ASP   A OD1 1 
ATOM   252  O OD2 . ASP   A 1 51  ? -16.46483 -36.64329 -32.81064 1.000 27.89896 ? 33   ASP   A OD2 1 
ATOM   253  N N   . LEU   A 1 52  ? -17.18799 -32.04368 -30.41637 1.000 22.09815 ? 34   LEU   A N   1 
ATOM   254  C CA  . LEU   A 1 52  ? -16.34489 -30.97630 -29.87978 1.000 15.45626 ? 34   LEU   A CA  1 
ATOM   255  C C   . LEU   A 1 52  ? -14.86618 -31.29724 -30.03074 1.000 19.02168 ? 34   LEU   A C   1 
ATOM   256  O O   . LEU   A 1 52  ? -14.05629 -30.40515 -30.31106 1.000 17.48198 ? 34   LEU   A O   1 
ATOM   257  C CB  . LEU   A 1 52  ? -16.66739 -30.74004 -28.41055 1.000 13.84701 ? 34   LEU   A CB  1 
ATOM   258  C CG  . LEU   A 1 52  ? -18.09696 -30.31807 -28.08998 1.000 17.68910 ? 34   LEU   A CG  1 
ATOM   259  C CD1 . LEU   A 1 52  ? -18.27559 -30.14154 -26.59215 1.000 14.85581 ? 34   LEU   A CD1 1 
ATOM   260  C CD2 . LEU   A 1 52  ? -18.37294 -29.03288 -28.83633 1.000 17.11509 ? 34   LEU   A CD2 1 
ATOM   261  N N   . VAL   A 1 53  ? -14.49157 -32.55993 -29.82276 1.000 18.72442 ? 35   VAL   A N   1 
ATOM   262  C CA  . VAL   A 1 53  ? -13.08401 -32.92893 -29.89409 1.000 17.17891 ? 35   VAL   A CA  1 
ATOM   263  C C   . VAL   A 1 53  ? -12.57533 -32.81901 -31.32323 1.000 17.15242 ? 35   VAL   A C   1 
ATOM   264  O O   . VAL   A 1 53  ? -11.51796 -32.22367 -31.57806 1.000 16.09837 ? 35   VAL   A O   1 
ATOM   265  C CB  . VAL   A 1 53  ? -12.85793 -34.33127 -29.30192 1.000 16.32172 ? 35   VAL   A CB  1 
ATOM   266  C CG1 . VAL   A 1 53  ? -11.43582 -34.79661 -29.58353 1.000 18.49523 ? 35   VAL   A CG1 1 
ATOM   267  C CG2 . VAL   A 1 53  ? -13.10499 -34.29474 -27.81264 1.000 20.12270 ? 35   VAL   A CG2 1 
ATOM   268  N N   . LEU   A 1 54  ? -13.33762 -33.35074 -32.28133 1.000 15.39958 ? 36   LEU   A N   1 
ATOM   269  C CA  . LEU   A 1 54  ? -12.94512 -33.24683 -33.68437 1.000 15.11849 ? 36   LEU   A CA  1 
ATOM   270  C C   . LEU   A 1 54  ? -12.80407 -31.79198 -34.11868 1.000 21.59288 ? 36   LEU   A C   1 
ATOM   271  O O   . LEU   A 1 54  ? -11.82831 -31.41758 -34.78445 1.000 15.67735 ? 36   LEU   A O   1 
ATOM   272  C CB  . LEU   A 1 54  ? -13.96951 -33.95857 -34.56801 1.000 17.33804 ? 36   LEU   A CB  1 
ATOM   273  C CG  . LEU   A 1 54  ? -13.75108 -33.73112 -36.06732 1.000 24.62257 ? 36   LEU   A CG  1 
ATOM   274  C CD1 . LEU   A 1 54  ? -12.40001 -34.28831 -36.51938 1.000 20.43938 ? 36   LEU   A CD1 1 
ATOM   275  C CD2 . LEU   A 1 54  ? -14.88940 -34.33727 -36.87770 1.000 24.43157 ? 36   LEU   A CD2 1 
ATOM   276  N N   . LEU   A 1 55  ? -13.79021 -30.95678 -33.77610 1.000 16.63712 ? 37   LEU   A N   1 
ATOM   277  C CA  . LEU   A 1 55  ? -13.77179 -29.58496 -34.26683 1.000 17.58424 ? 37   LEU   A CA  1 
ATOM   278  C C   . LEU   A 1 55  ? -12.66378 -28.77477 -33.61325 1.000 14.40625 ? 37   LEU   A C   1 
ATOM   279  O O   . LEU   A 1 55  ? -11.99495 -27.98055 -34.28537 1.000 15.43190 ? 37   LEU   A O   1 
ATOM   280  C CB  . LEU   A 1 55  ? -15.12666 -28.92177 -34.03224 1.000 14.67125 ? 37   LEU   A CB  1 
ATOM   281  C CG  . LEU   A 1 55  ? -16.29449 -29.55086 -34.79085 1.000 14.96452 ? 37   LEU   A CG  1 
ATOM   282  C CD1 . LEU   A 1 55  ? -17.60172 -29.05158 -34.19360 1.000 14.66814 ? 37   LEU   A CD1 1 
ATOM   283  C CD2 . LEU   A 1 55  ? -16.19115 -29.21908 -36.27918 1.000 14.56354 ? 37   LEU   A CD2 1 
ATOM   284  N N   . SER   A 1 56  ? -12.47026 -28.94735 -32.30377 1.000 11.93841 ? 38   SER   A N   1 
ATOM   285  C CA  . SER   A 1 56  ? -11.41274 -28.21520 -31.60200 1.000 15.52316 ? 38   SER   A CA  1 
ATOM   286  C C   . SER   A 1 56  ? -10.02593 -28.62661 -32.08921 1.000 17.92461 ? 38   SER   A C   1 
ATOM   287  O O   . SER   A 1 56  ? -9.11653  -27.78939 -32.17289 1.000 14.83885 ? 38   SER   A O   1 
ATOM   288  C CB  . SER   A 1 56  ? -11.52839 -28.43467 -30.09062 1.000 13.68901 ? 38   SER   A CB  1 
ATOM   289  O OG  . SER   A 1 56  ? -10.46005 -27.78710 -29.38659 1.000 13.51878 ? 38   SER   A OG  1 
ATOM   290  N N   . LEU   A 1 57  ? -9.83560  -29.91486 -32.39230 1.000 15.59904 ? 39   LEU   A N   1 
ATOM   291  C CA  . LEU   A 1 57  ? -8.55478  -30.36302 -32.94280 1.000 13.41908 ? 39   LEU   A CA  1 
ATOM   292  C C   . LEU   A 1 57  ? -8.27701  -29.73693 -34.29974 1.000 14.12448 ? 39   LEU   A C   1 
ATOM   293  O O   . LEU   A 1 57  ? -7.13517  -29.37280 -34.59692 1.000 14.54330 ? 39   LEU   A O   1 
ATOM   294  C CB  . LEU   A 1 57  ? -8.50699  -31.88924 -33.05785 1.000 12.21028 ? 39   LEU   A CB  1 
ATOM   295  C CG  . LEU   A 1 57  ? -8.29158  -32.69739 -31.78027 1.000 23.26770 ? 39   LEU   A CG  1 
ATOM   296  C CD1 . LEU   A 1 57  ? -8.72551  -34.14625 -32.00210 1.000 28.03287 ? 39   LEU   A CD1 1 
ATOM   297  C CD2 . LEU   A 1 57  ? -6.82069  -32.61615 -31.31158 1.000 15.50190 ? 39   LEU   A CD2 1 
ATOM   298  N N   . VAL   A 1 58  ? -9.30210  -29.62387 -35.14726 1.000 13.71736 ? 40   VAL   A N   1 
ATOM   299  C CA  . VAL   A 1 58  ? -9.11172  -29.00899 -36.45713 1.000 16.93369 ? 40   VAL   A CA  1 
ATOM   300  C C   . VAL   A 1 58  ? -8.72455  -27.54126 -36.31016 1.000 12.68265 ? 40   VAL   A C   1 
ATOM   301  O O   . VAL   A 1 58  ? -7.77442  -27.06841 -36.94134 1.000 12.75034 ? 40   VAL   A O   1 
ATOM   302  C CB  . VAL   A 1 58  ? -10.37015 -29.18808 -37.32374 1.000 17.36556 ? 40   VAL   A CB  1 
ATOM   303  C CG1 . VAL   A 1 58  ? -10.35825 -28.20652 -38.48940 1.000 14.39596 ? 40   VAL   A CG1 1 
ATOM   304  C CG2 . VAL   A 1 58  ? -10.43672 -30.62456 -37.84244 1.000 14.67219 ? 40   VAL   A CG2 1 
ATOM   305  N N   . LEU   A 1 59  ? -9.45187  -26.79295 -35.47570 1.000 13.24582 ? 41   LEU   A N   1 
ATOM   306  C CA  . LEU   A 1 59  ? -9.10627  -25.38330 -35.28823 1.000 9.99938  ? 41   LEU   A CA  1 
ATOM   307  C C   . LEU   A 1 59  ? -7.70873  -25.23152 -34.70234 1.000 10.24574 ? 41   LEU   A C   1 
ATOM   308  O O   . LEU   A 1 59  ? -6.95220  -24.34724 -35.11511 1.000 14.48150 ? 41   LEU   A O   1 
ATOM   309  C CB  . LEU   A 1 59  ? -10.12224 -24.68876 -34.37695 1.000 13.92852 ? 41   LEU   A CB  1 
ATOM   310  C CG  . LEU   A 1 59  ? -11.56692 -24.54257 -34.88287 1.000 12.79704 ? 41   LEU   A CG  1 
ATOM   311  C CD1 . LEU   A 1 59  ? -12.39352 -23.77951 -33.84742 1.000 10.04726 ? 41   LEU   A CD1 1 
ATOM   312  C CD2 . LEU   A 1 59  ? -11.58650 -23.82955 -36.23537 1.000 12.58824 ? 41   LEU   A CD2 1 
ATOM   313  N N   . GLY   A 1 60  ? -7.36236  -26.06687 -33.71945 1.000 10.14744 ? 42   GLY   A N   1 
ATOM   314  C CA  . GLY   A 1 60  ? -6.03480  -25.98233 -33.12352 1.000 10.32261 ? 42   GLY   A CA  1 
ATOM   315  C C   . GLY   A 1 60  ? -4.92787  -26.32356 -34.10452 1.000 12.33781 ? 42   GLY   A C   1 
ATOM   316  O O   . GLY   A 1 60  ? -3.85269  -25.71412 -34.08252 1.000 14.74230 ? 42   GLY   A O   1 
ATOM   317  N N   . PHE   A 1 61  ? -5.17678  -27.29779 -34.98519 1.000 15.63591 ? 43   PHE   A N   1 
ATOM   318  C CA  . PHE   A 1 61  ? -4.19488  -27.64109 -36.01513 1.000 13.97292 ? 43   PHE   A CA  1 
ATOM   319  C C   . PHE   A 1 61  ? -3.98557  -26.47040 -36.96323 1.000 13.38178 ? 43   PHE   A C   1 
ATOM   320  O O   . PHE   A 1 61  ? -2.84998  -26.04540 -37.22196 1.000 10.86757 ? 43   PHE   A O   1 
ATOM   321  C CB  . PHE   A 1 61  ? -4.66722  -28.87579 -36.78774 1.000 16.11749 ? 43   PHE   A CB  1 
ATOM   322  C CG  . PHE   A 1 61  ? -3.83031  -29.19733 -37.99836 1.000 17.03287 ? 43   PHE   A CG  1 
ATOM   323  C CD1 . PHE   A 1 61  ? -2.71749  -30.01244 -37.88438 1.000 15.96785 ? 43   PHE   A CD1 1 
ATOM   324  C CD2 . PHE   A 1 61  ? -4.14753  -28.67675 -39.24497 1.000 20.69952 ? 43   PHE   A CD2 1 
ATOM   325  C CE1 . PHE   A 1 61  ? -1.94368  -30.31909 -38.98518 1.000 20.34869 ? 43   PHE   A CE1 1 
ATOM   326  C CE2 . PHE   A 1 61  ? -3.36810  -28.97866 -40.35907 1.000 18.53343 ? 43   PHE   A CE2 1 
ATOM   327  C CZ  . PHE   A 1 61  ? -2.26241  -29.80045 -40.22565 1.000 17.05348 ? 43   PHE   A CZ  1 
ATOM   328  N N   . VAL   A 1 62  ? -5.09138  -25.91908 -37.46939 1.000 11.77706 ? 44   VAL   A N   1 
ATOM   329  C CA  . VAL   A 1 62  ? -5.03057  -24.79552 -38.39113 1.000 15.27997 ? 44   VAL   A CA  1 
ATOM   330  C C   . VAL   A 1 62  ? -4.37176  -23.59625 -37.72007 1.000 13.61971 ? 44   VAL   A C   1 
ATOM   331  O O   . VAL   A 1 62  ? -3.51679  -22.92338 -38.31028 1.000 15.66389 ? 44   VAL   A O   1 
ATOM   332  C CB  . VAL   A 1 62  ? -6.45518  -24.48806 -38.89896 1.000 13.56414 ? 44   VAL   A CB  1 
ATOM   333  C CG1 . VAL   A 1 62  ? -6.52185  -23.14144 -39.60233 1.000 18.67198 ? 44   VAL   A CG1 1 
ATOM   334  C CG2 . VAL   A 1 62  ? -6.93162  -25.62512 -39.81045 1.000 14.58952 ? 44   VAL   A CG2 1 
ATOM   335  N N   . GLU   A 1 63  ? -4.73128  -23.32676 -36.46350 1.000 14.28628 ? 45   GLU   A N   1 
ATOM   336  C CA  . GLU   A 1 63  ? -4.11906  -22.20590 -35.76213 1.000 13.87265 ? 45   GLU   A CA  1 
ATOM   337  C C   . GLU   A 1 63  ? -2.62977  -22.43445 -35.52932 1.000 13.57101 ? 45   GLU   A C   1 
ATOM   338  O O   . GLU   A 1 63  ? -1.83100  -21.50153 -35.66002 1.000 13.34999 ? 45   GLU   A O   1 
ATOM   339  C CB  . GLU   A 1 63  ? -4.83455  -21.95269 -34.43442 1.000 17.06018 ? 45   GLU   A CB  1 
ATOM   340  C CG  . GLU   A 1 63  ? -4.30359  -20.72562 -33.69531 1.000 11.59521 ? 45   GLU   A CG  1 
ATOM   341  C CD  . GLU   A 1 63  ? -5.25414  -20.22983 -32.61917 1.000 14.71535 ? 45   GLU   A CD  1 
ATOM   342  O OE1 . GLU   A 1 63  ? -6.47307  -20.15151 -32.89137 1.000 16.32474 ? 45   GLU   A OE1 1 
ATOM   343  O OE2 . GLU   A 1 63  ? -4.78346  -19.93516 -31.49794 1.000 14.73399 ? 45   GLU   A OE2 1 
ATOM   344  N N   . HIS   A 1 64  ? -2.22954  -23.66442 -35.19809 1.000 12.77039 ? 46   HIS   A N   1 
ATOM   345  C CA  . HIS   A 1 64  ? -0.81542  -23.91766 -34.94051 1.000 13.02621 ? 46   HIS   A CA  1 
ATOM   346  C C   . HIS   A 1 64  ? 0.03975   -23.54536 -36.14487 1.000 13.84458 ? 46   HIS   A C   1 
ATOM   347  O O   . HIS   A 1 64  ? 1.06628   -22.87351 -36.01050 1.000 14.34293 ? 46   HIS   A O   1 
ATOM   348  C CB  . HIS   A 1 64  ? -0.57088  -25.37995 -34.57518 1.000 13.34901 ? 46   HIS   A CB  1 
ATOM   349  C CG  . HIS   A 1 64  ? 0.88365   -25.69771 -34.43112 1.000 13.02249 ? 46   HIS   A CG  1 
ATOM   350  N ND1 . HIS   A 1 64  ? 1.56936   -25.52654 -33.24822 1.000 15.95242 ? 46   HIS   A ND1 1 
ATOM   351  C CD2 . HIS   A 1 64  ? 1.79980   -26.09980 -35.34273 1.000 16.47193 ? 46   HIS   A CD2 1 
ATOM   352  C CE1 . HIS   A 1 64  ? 2.84150   -25.83969 -33.43002 1.000 15.63558 ? 46   HIS   A CE1 1 
ATOM   353  N NE2 . HIS   A 1 64  ? 3.00833   -26.18240 -34.69470 1.000 17.93795 ? 46   HIS   A NE2 1 
ATOM   354  N N   . PHE   A 1 65  ? -0.37811  -23.95461 -37.33352 1.000 13.02320 ? 47   PHE   A N   1 
ATOM   355  C CA  . PHE   A 1 65  ? 0.41991   -23.71134 -38.52146 1.000 13.67376 ? 47   PHE   A CA  1 
ATOM   356  C C   . PHE   A 1 65  ? 0.11959   -22.37523 -39.18945 1.000 27.32763 ? 47   PHE   A C   1 
ATOM   357  O O   . PHE   A 1 65  ? 0.80492   -22.02290 -40.15605 1.000 20.17444 ? 47   PHE   A O   1 
ATOM   358  C CB  . PHE   A 1 65  ? 0.23248   -24.87046 -39.49737 1.000 16.43301 ? 47   PHE   A CB  1 
ATOM   359  C CG  . PHE   A 1 65  ? 0.90941   -26.13061 -39.04959 1.000 15.85864 ? 47   PHE   A CG  1 
ATOM   360  C CD1 . PHE   A 1 65  ? 2.29884   -26.21066 -39.02438 1.000 17.42882 ? 47   PHE   A CD1 1 
ATOM   361  C CD2 . PHE   A 1 65  ? 0.16605   -27.22186 -38.62079 1.000 14.06621 ? 47   PHE   A CD2 1 
ATOM   362  C CE1 . PHE   A 1 65  ? 2.92882   -27.37180 -38.59996 1.000 22.29942 ? 47   PHE   A CE1 1 
ATOM   363  C CE2 . PHE   A 1 65  ? 0.79143   -28.38623 -38.19005 1.000 15.03133 ? 47   PHE   A CE2 1 
ATOM   364  C CZ  . PHE   A 1 65  ? 2.16971   -28.45839 -38.18151 1.000 14.97980 ? 47   PHE   A CZ  1 
ATOM   365  N N   . LEU   A 1 66  ? -0.86131  -21.61334 -38.68493 1.000 18.63986 ? 48   LEU   A N   1 
ATOM   366  C CA  . LEU   A 1 66  ? -1.06866  -20.23695 -39.11872 1.000 15.05736 ? 48   LEU   A CA  1 
ATOM   367  C C   . LEU   A 1 66  ? -0.58557  -19.19562 -38.11235 1.000 21.86270 ? 48   LEU   A C   1 
ATOM   368  O O   . LEU   A 1 66  ? -0.29877  -18.06186 -38.51600 1.000 21.91167 ? 48   LEU   A O   1 
ATOM   369  C CB  . LEU   A 1 66  ? -2.55087  -19.98253 -39.43371 1.000 16.24314 ? 48   LEU   A CB  1 
ATOM   370  C CG  . LEU   A 1 66  ? -2.99849  -20.54157 -40.78696 1.000 16.85764 ? 48   LEU   A CG  1 
ATOM   371  C CD1 . LEU   A 1 66  ? -4.51088  -20.61831 -40.90479 1.000 17.67285 ? 48   LEU   A CD1 1 
ATOM   372  C CD2 . LEU   A 1 66  ? -2.40145  -19.68064 -41.90617 1.000 21.69137 ? 48   LEU   A CD2 1 
ATOM   373  N N   . ALA   A 1 67  ? -0.45815  -19.54686 -36.82468 1.000 16.23818 ? 49   ALA   A N   1 
ATOM   374  C CA  . ALA   A 1 67  ? -0.06500  -18.54208 -35.83942 1.000 19.75980 ? 49   ALA   A CA  1 
ATOM   375  C C   . ALA   A 1 67  ? 1.09356   -18.97150 -34.94600 1.000 18.68005 ? 49   ALA   A C   1 
ATOM   376  O O   . ALA   A 1 67  ? 1.91383   -18.12864 -34.57402 1.000 17.83499 ? 49   ALA   A O   1 
ATOM   377  C CB  . ALA   A 1 67  ? -1.28247  -18.16186 -34.96886 1.000 12.83149 ? 49   ALA   A CB  1 
ATOM   378  N N   . VAL   A 1 68  ? 1.17602   -20.25056 -34.57568 1.000 15.27027 ? 50   VAL   A N   1 
ATOM   379  C CA  . VAL   A 1 68  ? 2.26654   -20.69094 -33.70893 1.000 20.40438 ? 50   VAL   A CA  1 
ATOM   380  C C   . VAL   A 1 68  ? 3.55425   -20.83927 -34.50197 1.000 21.25877 ? 50   VAL   A C   1 
ATOM   381  O O   . VAL   A 1 68  ? 4.59796   -20.28683 -34.13715 1.000 20.70312 ? 50   VAL   A O   1 
ATOM   382  C CB  . VAL   A 1 68  ? 1.90342   -22.00628 -32.99754 1.000 18.84737 ? 50   VAL   A CB  1 
ATOM   383  C CG1 . VAL   A 1 68  ? 3.04887   -22.44697 -32.08368 1.000 13.63550 ? 50   VAL   A CG1 1 
ATOM   384  C CG2 . VAL   A 1 68  ? 0.61492   -21.85096 -32.21001 1.000 16.27661 ? 50   VAL   A CG2 1 
ATOM   385  N N   . ASN   A 1 69  ? 3.51188   -21.61341 -35.57591 1.000 15.33880 ? 51   ASN   A N   1 
ATOM   386  C CA  . ASN   A 1 69  ? 4.64853   -21.75667 -36.48286 1.000 20.75790 ? 51   ASN   A CA  1 
ATOM   387  C C   . ASN   A 1 69  ? 4.18977   -21.10196 -37.78121 1.000 24.88658 ? 51   ASN   A C   1 
ATOM   388  O O   . ASN   A 1 69  ? 3.57082   -21.74000 -38.62968 1.000 28.65460 ? 51   ASN   A O   1 
ATOM   389  C CB  . ASN   A 1 69  ? 5.04646   -23.23131 -36.64964 1.000 28.96127 ? 51   ASN   A CB  1 
ATOM   390  C CG  . ASN   A 1 69  ? 5.97207   -23.47976 -37.84245 1.000 45.55657 ? 51   ASN   A CG  1 
ATOM   391  O OD1 . ASN   A 1 69  ? 6.33920   -22.56300 -38.58336 1.000 36.22905 ? 51   ASN   A OD1 1 
ATOM   392  N ND2 . ASN   A 1 69  ? 6.35960   -24.74088 -38.02303 1.000 37.66949 ? 51   ASN   A ND2 1 
ATOM   393  N N   . ARG   A 1 70  ? 4.47127   -19.80857 -37.91914 1.000 22.17373 ? 52   ARG   A N   1 
ATOM   394  C CA  . ARG   A 1 70  ? 4.09623   -19.09957 -39.13585 1.000 26.18865 ? 52   ARG   A CA  1 
ATOM   395  C C   . ARG   A 1 70  ? 5.07870   -19.48575 -40.23552 1.000 29.77222 ? 52   ARG   A C   1 
ATOM   396  O O   . ARG   A 1 70  ? 6.25862   -19.12883 -40.17962 1.000 27.95356 ? 52   ARG   A O   1 
ATOM   397  C CB  . ARG   A 1 70  ? 4.05887   -17.58996 -38.90697 1.000 26.97157 ? 52   ARG   A CB  1 
ATOM   398  C CG  . ARG   A 1 70  ? 3.67962   -16.84785 -40.16973 1.000 23.99061 ? 52   ARG   A CG  1 
ATOM   399  C CD  . ARG   A 1 70  ? 2.20924   -16.51527 -40.17548 1.000 22.73326 ? 52   ARG   A CD  1 
ATOM   400  N NE  . ARG   A 1 70  ? 1.77432   -16.03517 -41.48028 1.000 23.75027 ? 52   ARG   A NE  1 
ATOM   401  C CZ  . ARG   A 1 70  ? 0.54194   -16.17347 -41.94643 1.000 24.30444 ? 52   ARG   A CZ  1 
ATOM   402  N NH1 . ARG   A 1 70  ? -0.41747  -16.72380 -41.21307 1.000 21.68855 ? 52   ARG   A NH1 1 
ATOM   403  N NH2 . ARG   A 1 70  ? 0.26042   -15.73685 -43.17151 1.000 19.21777 ? 52   ARG   A NH2 1 
ATOM   404  N N   . VAL   A 1 71  ? 4.59054   -20.22165 -41.23453 1.000 23.79192 ? 53   VAL   A N   1 
ATOM   405  C CA  . VAL   A 1 71  ? 5.47797   -20.78034 -42.25072 1.000 25.53547 ? 53   VAL   A CA  1 
ATOM   406  C C   . VAL   A 1 71  ? 6.00776   -19.69078 -43.17588 1.000 27.74923 ? 53   VAL   A C   1 
ATOM   407  O O   . VAL   A 1 71  ? 7.18298   -19.69872 -43.55572 1.000 28.71237 ? 53   VAL   A O   1 
ATOM   408  C CB  . VAL   A 1 71  ? 4.73992   -21.88298 -43.02415 1.000 23.70785 ? 53   VAL   A CB  1 
ATOM   409  C CG1 . VAL   A 1 71  ? 5.70827   -22.65812 -43.89959 1.000 28.68819 ? 53   VAL   A CG1 1 
ATOM   410  C CG2 . VAL   A 1 71  ? 4.05933   -22.80497 -42.04130 1.000 23.68100 ? 53   VAL   A CG2 1 
ATOM   411  N N   . ILE   A 1 72  ? 5.15775   -18.74755 -43.55768 1.000 26.08172 ? 54   ILE   A N   1 
ATOM   412  C CA  . ILE   A 1 72  ? 5.52962   -17.63439 -44.41950 1.000 34.56377 ? 54   ILE   A CA  1 
ATOM   413  C C   . ILE   A 1 72  ? 5.31441   -16.33397 -43.65477 1.000 30.35237 ? 54   ILE   A C   1 
ATOM   414  O O   . ILE   A 1 72  ? 4.21015   -16.08175 -43.16049 1.000 31.20073 ? 54   ILE   A O   1 
ATOM   415  C CB  . ILE   A 1 72  ? 4.74111   -17.63068 -45.74122 1.000 31.20936 ? 54   ILE   A CB  1 
ATOM   416  C CG1 . ILE   A 1 72  ? 4.70381   -19.04083 -46.34092 1.000 41.91120 ? 54   ILE   A CG1 1 
ATOM   417  C CG2 . ILE   A 1 72  ? 5.29705   -16.59673 -46.71676 1.000 35.00170 ? 54   ILE   A CG2 1 
ATOM   418  C CD1 . ILE   A 1 72  ? 3.38987   -19.42640 -46.96283 1.000 38.74532 ? 54   ILE   A CD1 1 
ATOM   419  N N   . PRO   A 1 73  ? 6.32842   -15.47808 -43.53526 1.000 31.67025 ? 55   PRO   A N   1 
ATOM   420  C CA  . PRO   A 1 73  ? 6.13707   -14.20132 -42.84017 1.000 36.76537 ? 55   PRO   A CA  1 
ATOM   421  C C   . PRO   A 1 73  ? 5.11485   -13.32458 -43.55052 1.000 24.56917 ? 55   PRO   A C   1 
ATOM   422  O O   . PRO   A 1 73  ? 4.75223   -13.54792 -44.70812 1.000 30.37185 ? 55   PRO   A O   1 
ATOM   423  C CB  . PRO   A 1 73  ? 7.53851   -13.57980 -42.86350 1.000 37.34271 ? 55   PRO   A CB  1 
ATOM   424  C CG  . PRO   A 1 73  ? 8.15554   -14.13613 -44.11624 1.000 32.05297 ? 55   PRO   A CG  1 
ATOM   425  C CD  . PRO   A 1 73  ? 7.66121   -15.56822 -44.16411 1.000 36.06905 ? 55   PRO   A CD  1 
ATOM   426  N N   . THR   A 1 74  ? 4.63419   -12.32058 -42.83025 1.000 26.74541 ? 56   THR   A N   1 
ATOM   427  C CA  . THR   A 1 74  ? 3.55723   -11.47834 -43.33518 1.000 36.75154 ? 56   THR   A CA  1 
ATOM   428  C C   . THR   A 1 74  ? 4.07772   -10.18241 -43.94981 1.000 31.17632 ? 56   THR   A C   1 
ATOM   429  O O   . THR   A 1 74  ? 3.28778   -9.33198  -44.36811 1.000 39.57054 ? 56   THR   A O   1 
ATOM   430  C CB  . THR   A 1 74  ? 2.56072   -11.13725 -42.22078 1.000 34.00329 ? 56   THR   A CB  1 
ATOM   431  O OG1 . THR   A 1 74  ? 3.26476   -10.51341 -41.13716 1.000 34.74892 ? 56   THR   A OG1 1 
ATOM   432  C CG2 . THR   A 1 74  ? 1.86780   -12.40786 -41.72381 1.000 24.93412 ? 56   THR   A CG2 1 
ATOM   433  N N   . PRO   A 1 77  ? 6.47894   -6.35938  -49.38692 1.000 39.50593 ? 59   PRO   A N   1 
ATOM   434  C CA  . PRO   A 1 77  ? 7.63004   -5.62317  -49.92236 1.000 38.52460 ? 59   PRO   A CA  1 
ATOM   435  C C   . PRO   A 1 77  ? 7.32009   -4.14406  -50.14037 1.000 43.26637 ? 59   PRO   A C   1 
ATOM   436  O O   . PRO   A 1 77  ? 6.14930   -3.78323  -50.28132 1.000 33.02215 ? 59   PRO   A O   1 
ATOM   437  C CB  . PRO   A 1 77  ? 7.90144   -6.31858  -51.26249 1.000 43.24328 ? 59   PRO   A CB  1 
ATOM   438  C CG  . PRO   A 1 77  ? 7.32573   -7.67456  -51.11103 1.000 36.73531 ? 59   PRO   A CG  1 
ATOM   439  C CD  . PRO   A 1 77  ? 6.09746   -7.48070  -50.26172 1.000 32.39558 ? 59   PRO   A CD  1 
ATOM   440  N N   . GLU   A 1 78  ? 8.35719   -3.30888  -50.17416 1.000 43.34321 ? 60   GLU   A N   1 
ATOM   441  C CA  . GLU   A 1 78  ? 8.19063   -1.87270  -50.38866 1.000 41.84745 ? 60   GLU   A CA  1 
ATOM   442  C C   . GLU   A 1 78  ? 7.49168   -1.58508  -51.71700 1.000 41.39277 ? 60   GLU   A C   1 
ATOM   443  O O   . GLU   A 1 78  ? 7.78958   -2.21177  -52.73262 1.000 36.82828 ? 60   GLU   A O   1 
ATOM   444  C CB  . GLU   A 1 78  ? 9.54906   -1.16095  -50.34328 1.000 45.95424 ? 60   GLU   A CB  1 
ATOM   445  C CG  . GLU   A 1 78  ? 9.48580   0.32318   -50.69447 1.000 59.37019 ? 60   GLU   A CG  1 
ATOM   446  C CD  . GLU   A 1 78  ? 10.79970  0.87325   -51.23791 1.000 55.05104 ? 60   GLU   A CD  1 
ATOM   447  O OE1 . GLU   A 1 78  ? 11.41525  0.23375   -52.11940 1.000 46.28426 ? 60   GLU   A OE1 1 
ATOM   448  O OE2 . GLU   A 1 78  ? 11.21373  1.95829   -50.78164 1.000 40.79273 ? 60   GLU   A OE2 1 
ATOM   449  N N   . PHE   A 1 81  ? 7.31056   -0.24558  -58.63504 1.000 50.32514 ? 63   PHE   A N   1 
ATOM   450  C CA  . PHE   A 1 81  ? 6.81663   -0.66980  -59.94273 1.000 43.49788 ? 63   PHE   A CA  1 
ATOM   451  C C   . PHE   A 1 81  ? 7.95830   -0.78289  -60.95398 1.000 51.90537 ? 63   PHE   A C   1 
ATOM   452  O O   . PHE   A 1 81  ? 9.01728   -0.17398  -60.77843 1.000 50.85193 ? 63   PHE   A O   1 
ATOM   453  C CB  . PHE   A 1 81  ? 5.75100   0.30192   -60.45826 1.000 37.58420 ? 63   PHE   A CB  1 
ATOM   454  C CG  . PHE   A 1 81  ? 4.47219   0.27588   -59.66670 1.000 51.14195 ? 63   PHE   A CG  1 
ATOM   455  C CD1 . PHE   A 1 81  ? 3.64600   -0.84075  -59.68969 1.000 52.16105 ? 63   PHE   A CD1 1 
ATOM   456  C CD2 . PHE   A 1 81  ? 4.10075   1.36595   -58.88770 1.000 44.84075 ? 63   PHE   A CD2 1 
ATOM   457  C CE1 . PHE   A 1 81  ? 2.47048   -0.87116  -58.95371 1.000 29.13061 ? 63   PHE   A CE1 1 
ATOM   458  C CE2 . PHE   A 1 81  ? 2.92466   1.34478   -58.14785 1.000 44.19942 ? 63   PHE   A CE2 1 
ATOM   459  C CZ  . PHE   A 1 81  ? 2.10526   0.22269   -58.18393 1.000 42.08434 ? 63   PHE   A CZ  1 
ATOM   460  N N   . GLN   A 1 82  ? 7.72320   -1.55532  -62.00942 1.000 43.78660 ? 64   GLN   A N   1 
ATOM   461  C CA  . GLN   A 1 82  ? 8.70983   -1.84424  -63.04449 1.000 45.39482 ? 64   GLN   A CA  1 
ATOM   462  C C   . GLN   A 1 82  ? 7.98570   -2.52045  -64.21493 1.000 45.78338 ? 64   GLN   A C   1 
ATOM   463  O O   . GLN   A 1 82  ? 6.84083   -2.95781  -64.06313 1.000 35.82018 ? 64   GLN   A O   1 
ATOM   464  C CB  . GLN   A 1 82  ? 9.84608   -2.73618  -62.50544 1.000 32.19838 ? 64   GLN   A CB  1 
ATOM   465  C CG  . GLN   A 1 82  ? 9.43979   -4.17045  -62.19173 1.000 45.54861 ? 64   GLN   A CG  1 
ATOM   466  C CD  . GLN   A 1 82  ? 8.53844   -4.26559  -60.96997 1.000 49.70677 ? 64   GLN   A CD  1 
ATOM   467  O OE1 . GLN   A 1 82  ? 8.81613   -3.65950  -59.93239 1.000 47.62751 ? 64   GLN   A OE1 1 
ATOM   468  N NE2 . GLN   A 1 82  ? 7.45110   -5.02532  -61.08870 1.000 33.29383 ? 64   GLN   A NE2 1 
ATOM   469  N N   . PRO   A 1 83  ? 8.61768   -2.58878  -65.39377 1.000 38.72969 ? 65   PRO   A N   1 
ATOM   470  C CA  . PRO   A 1 83  ? 7.92101   -3.20293  -66.54260 1.000 40.80401 ? 65   PRO   A CA  1 
ATOM   471  C C   . PRO   A 1 83  ? 7.61050   -4.68464  -66.36582 1.000 42.74915 ? 65   PRO   A C   1 
ATOM   472  O O   . PRO   A 1 83  ? 6.55006   -5.13888  -66.81484 1.000 32.18639 ? 65   PRO   A O   1 
ATOM   473  C CB  . PRO   A 1 83  ? 8.88852   -2.95283  -67.71025 1.000 42.62080 ? 65   PRO   A CB  1 
ATOM   474  C CG  . PRO   A 1 83  ? 9.71239   -1.77457  -67.27531 1.000 44.47121 ? 65   PRO   A CG  1 
ATOM   475  C CD  . PRO   A 1 83  ? 9.87769   -1.93701  -65.79847 1.000 41.95921 ? 65   PRO   A CD  1 
ATOM   476  N N   . SER   A 1 84  ? 8.49712   -5.44382  -65.72698 1.000 37.58113 ? 66   SER   A N   1 
ATOM   477  C CA  . SER   A 1 84  ? 8.34182   -6.88016  -65.51732 1.000 34.69457 ? 66   SER   A CA  1 
ATOM   478  C C   . SER   A 1 84  ? 7.51409   -7.14590  -64.26955 1.000 30.34052 ? 66   SER   A C   1 
ATOM   479  O O   . SER   A 1 84  ? 7.15384   -6.21834  -63.53935 1.000 36.10791 ? 66   SER   A O   1 
ATOM   480  C CB  . SER   A 1 84  ? 9.72314   -7.52282  -65.40525 1.000 35.82397 ? 66   SER   A CB  1 
ATOM   481  O OG  . SER   A 1 84  ? 10.49340  -7.27191  -66.57095 1.000 39.10050 ? 66   SER   A OG  1 
ATOM   482  N N   . PRO   A 1 85  ? 7.16628   -8.40795  -63.99308 1.000 24.21230 ? 67   PRO   A N   1 
ATOM   483  C CA  . PRO   A 1 85  ? 6.51545   -8.71169  -62.71227 1.000 26.38447 ? 67   PRO   A CA  1 
ATOM   484  C C   . PRO   A 1 85  ? 7.49917   -8.61230  -61.55751 1.000 30.43467 ? 67   PRO   A C   1 
ATOM   485  O O   . PRO   A 1 85  ? 8.71019   -8.76486  -61.73177 1.000 25.89765 ? 67   PRO   A O   1 
ATOM   486  C CB  . PRO   A 1 85  ? 6.01134   -10.15055 -62.89354 1.000 25.79560 ? 67   PRO   A CB  1 
ATOM   487  C CG  . PRO   A 1 85  ? 6.84473   -10.70512 -63.97885 1.000 31.09083 ? 67   PRO   A CG  1 
ATOM   488  C CD  . PRO   A 1 85  ? 7.10873   -9.56243  -64.90686 1.000 25.21283 ? 67   PRO   A CD  1 
ATOM   489  N N   . ALA   A 1 86  ? 6.96167   -8.34717  -60.36492 1.000 24.63797 ? 68   ALA   A N   1 
ATOM   490  C CA  . ALA   A 1 86  ? 7.80435   -8.24122  -59.18282 1.000 28.74964 ? 68   ALA   A CA  1 
ATOM   491  C C   . ALA   A 1 86  ? 8.42422   -9.59759  -58.84654 1.000 25.93486 ? 68   ALA   A C   1 
ATOM   492  O O   . ALA   A 1 86  ? 7.82120   -10.64587 -59.09861 1.000 24.95014 ? 68   ALA   A O   1 
ATOM   493  C CB  . ALA   A 1 86  ? 6.99931   -7.72535  -57.98902 1.000 26.26155 ? 68   ALA   A CB  1 
ATOM   494  N N   . PRO   A 1 87  ? 9.63605   -9.60486  -58.28319 1.000 26.92550 ? 69   PRO   A N   1 
ATOM   495  C CA  . PRO   A 1 87  ? 10.28436  -10.88723 -57.96925 1.000 25.16909 ? 69   PRO   A CA  1 
ATOM   496  C C   . PRO   A 1 87  ? 9.53786   -11.68182 -56.92333 1.000 28.39838 ? 69   PRO   A C   1 
ATOM   497  O O   . PRO   A 1 87  ? 9.57573   -12.91801 -56.94834 1.000 24.22046 ? 69   PRO   A O   1 
ATOM   498  C CB  . PRO   A 1 87  ? 11.67669  -10.48604 -57.45493 1.000 30.58232 ? 69   PRO   A CB  1 
ATOM   499  C CG  . PRO   A 1 87  ? 11.72243  -9.01965  -57.42733 1.000 23.69387 ? 69   PRO   A CG  1 
ATOM   500  C CD  . PRO   A 1 87  ? 10.49883  -8.43797  -58.03062 1.000 34.99028 ? 69   PRO   A CD  1 
ATOM   501  N N   . ASP   A 1 88  ? 8.88121   -11.00750 -55.98790 1.000 24.69859 ? 70   ASP   A N   1 
ATOM   502  C CA  . ASP   A 1 88  ? 8.11745   -11.64363 -54.93074 1.000 21.67797 ? 70   ASP   A CA  1 
ATOM   503  C C   . ASP   A 1 88  ? 6.70452   -11.08893 -54.94774 1.000 22.05687 ? 70   ASP   A C   1 
ATOM   504  O O   . ASP   A 1 88  ? 6.49127   -9.95779  -55.39145 1.000 24.53146 ? 70   ASP   A O   1 
ATOM   505  C CB  . ASP   A 1 88  ? 8.76221   -11.39451 -53.56245 1.000 33.63761 ? 70   ASP   A CB  1 
ATOM   506  C CG  . ASP   A 1 88  ? 10.20908  -11.85072 -53.51719 1.000 34.46638 ? 70   ASP   A CG  1 
ATOM   507  O OD1 . ASP   A 1 88  ? 10.44160  -13.07636 -53.53683 1.000 31.23951 ? 70   ASP   A OD1 1 
ATOM   508  O OD2 . ASP   A 1 88  ? 11.10711  -10.98145 -53.49005 1.000 32.41000 ? 70   ASP   A OD2 1 
ATOM   509  N N   . PRO   A 1 89  ? 5.72139   -11.86797 -54.50191 1.000 25.12484 ? 71   PRO   A N   1 
ATOM   510  C CA  . PRO   A 1 89  ? 4.32889   -11.38484 -54.48283 1.000 22.91584 ? 71   PRO   A CA  1 
ATOM   511  C C   . PRO   A 1 89  ? 4.22935   -10.02263 -53.81811 1.000 19.62522 ? 71   PRO   A C   1 
ATOM   512  O O   . PRO   A 1 89  ? 4.51652   -9.87248  -52.62110 1.000 19.06295 ? 71   PRO   A O   1 
ATOM   513  C CB  . PRO   A 1 89  ? 3.59984   -12.46459 -53.67752 1.000 17.59832 ? 71   PRO   A CB  1 
ATOM   514  C CG  . PRO   A 1 89  ? 4.38690   -13.71005 -53.96867 1.000 22.76442 ? 71   PRO   A CG  1 
ATOM   515  C CD  . PRO   A 1 89  ? 5.82802   -13.25701 -54.02178 1.000 20.59473 ? 71   PRO   A CD  1 
ATOM   516  N N   . PRO   A 1 90  ? 3.85290   -8.99329  -54.57779 1.000 19.80039 ? 72   PRO   A N   1 
ATOM   517  C CA  . PRO   A 1 90  ? 3.98694   -7.61651  -54.07040 1.000 19.89313 ? 72   PRO   A CA  1 
ATOM   518  C C   . PRO   A 1 90  ? 3.05649   -7.30061  -52.91778 1.000 25.70746 ? 72   PRO   A C   1 
ATOM   519  O O   . PRO   A 1 90  ? 3.28382   -6.30935  -52.20877 1.000 23.53559 ? 72   PRO   A O   1 
ATOM   520  C CB  . PRO   A 1 90  ? 3.66427   -6.75224  -55.29818 1.000 22.16636 ? 72   PRO   A CB  1 
ATOM   521  C CG  . PRO   A 1 90  ? 2.89972   -7.66302  -56.22465 1.000 21.98633 ? 72   PRO   A CG  1 
ATOM   522  C CD  . PRO   A 1 90  ? 3.43807   -9.03887  -55.98925 1.000 21.94257 ? 72   PRO   A CD  1 
ATOM   523  N N   . GLY   A 1 91  ? 2.01321   -8.10143  -52.71006 1.000 22.26699 ? 73   GLY   A N   1 
ATOM   524  C CA  . GLY   A 1 91  ? 1.11800   -7.92213  -51.58804 1.000 21.24754 ? 73   GLY   A CA  1 
ATOM   525  C C   . GLY   A 1 91  ? 1.25101   -8.97760  -50.52012 1.000 21.15214 ? 73   GLY   A C   1 
ATOM   526  O O   . GLY   A 1 91  ? 0.36377   -9.08257  -49.66336 1.000 23.02766 ? 73   GLY   A O   1 
ATOM   527  N N   . GLY   A 1 92  ? 2.32234   -9.76363  -50.52975 1.000 21.86913 ? 74   GLY   A N   1 
ATOM   528  C CA  . GLY   A 1 92  ? 2.44231   -10.85126 -49.60005 1.000 21.24209 ? 74   GLY   A CA  1 
ATOM   529  C C   . GLY   A 1 92  ? 1.54097   -12.00677 -49.99784 1.000 25.22953 ? 74   GLY   A C   1 
ATOM   530  O O   . GLY   A 1 92  ? 0.94960   -12.04401 -51.08367 1.000 18.32197 ? 74   GLY   A O   1 
ATOM   531  N N   . LEU   A 1 93  ? 1.43673   -12.95620 -49.07064 1.000 19.77539 ? 75   LEU   A N   1 
ATOM   532  C CA  . LEU   A 1 93  ? 0.75357   -14.22335 -49.28254 1.000 22.53627 ? 75   LEU   A CA  1 
ATOM   533  C C   . LEU   A 1 93  ? -0.12902  -14.52769 -48.08456 1.000 23.31515 ? 75   LEU   A C   1 
ATOM   534  O O   . LEU   A 1 93  ? 0.25228   -14.25584 -46.94294 1.000 25.70983 ? 75   LEU   A O   1 
ATOM   535  C CB  . LEU   A 1 93  ? 1.74716   -15.38566 -49.44381 1.000 31.12993 ? 75   LEU   A CB  1 
ATOM   536  C CG  . LEU   A 1 93  ? 2.66284   -15.55299 -50.65194 1.000 32.48013 ? 75   LEU   A CG  1 
ATOM   537  C CD1 . LEU   A 1 93  ? 3.83575   -14.59662 -50.55497 1.000 37.96006 ? 75   LEU   A CD1 1 
ATOM   538  C CD2 . LEU   A 1 93  ? 3.17292   -16.96898 -50.66393 1.000 30.95926 ? 75   LEU   A CD2 1 
ATOM   539  N N   . THR   A 1 94  ? -1.30191  -15.09119 -48.34678 1.000 16.06905 ? 76   THR   A N   1 
ATOM   540  C CA  . THR   A 1 94  ? -2.05917  -15.82588 -47.34716 1.000 18.62496 ? 76   THR   A CA  1 
ATOM   541  C C   . THR   A 1 94  ? -1.92830  -17.30700 -47.67233 1.000 22.38610 ? 76   THR   A C   1 
ATOM   542  O O   . THR   A 1 94  ? -1.63276  -17.68005 -48.80859 1.000 19.76438 ? 76   THR   A O   1 
ATOM   543  C CB  . THR   A 1 94  ? -3.53719  -15.40893 -47.32554 1.000 25.33360 ? 76   THR   A CB  1 
ATOM   544  O OG1 . THR   A 1 94  ? -4.16083  -15.76201 -48.56859 1.000 18.93425 ? 76   THR   A OG1 1 
ATOM   545  C CG2 . THR   A 1 94  ? -3.67424  -13.91769 -47.10057 1.000 20.66933 ? 76   THR   A CG2 1 
ATOM   546  N N   . TYR   A 1 95  ? -2.10985  -18.16072 -46.67038 1.000 16.67690 ? 77   TYR   A N   1 
ATOM   547  C CA  . TYR   A 1 95  ? -1.94715  -19.58236 -46.93193 1.000 21.79276 ? 77   TYR   A CA  1 
ATOM   548  C C   . TYR   A 1 95  ? -2.88516  -20.37480 -46.04151 1.000 27.08361 ? 77   TYR   A C   1 
ATOM   549  O O   . TYR   A 1 95  ? -3.57776  -19.82843 -45.18108 1.000 23.73114 ? 77   TYR   A O   1 
ATOM   550  C CB  . TYR   A 1 95  ? -0.48577  -20.04306 -46.76076 1.000 20.46487 ? 77   TYR   A CB  1 
ATOM   551  C CG  . TYR   A 1 95  ? 0.11262   -20.02785 -45.35853 1.000 21.02887 ? 77   TYR   A CG  1 
ATOM   552  C CD1 . TYR   A 1 95  ? -0.02394  -21.12880 -44.51240 1.000 27.17768 ? 77   TYR   A CD1 1 
ATOM   553  C CD2 . TYR   A 1 95  ? 0.85626   -18.94032 -44.89962 1.000 27.79583 ? 77   TYR   A CD2 1 
ATOM   554  C CE1 . TYR   A 1 95  ? 0.53900   -21.14196 -43.24010 1.000 22.87477 ? 77   TYR   A CE1 1 
ATOM   555  C CE2 . TYR   A 1 95  ? 1.43271   -18.94588 -43.62142 1.000 27.49095 ? 77   TYR   A CE2 1 
ATOM   556  C CZ  . TYR   A 1 95  ? 1.26254   -20.05462 -42.79926 1.000 22.33495 ? 77   TYR   A CZ  1 
ATOM   557  O OH  . TYR   A 1 95  ? 1.81143   -20.07952 -41.53566 1.000 24.14135 ? 77   TYR   A OH  1 
ATOM   558  N N   . PHE   A 1 96  ? -2.92508  -21.68256 -46.29151 1.000 22.25329 ? 78   PHE   A N   1 
ATOM   559  C CA  . PHE   A 1 96  ? -3.72898  -22.58780 -45.51129 1.000 17.25549 ? 78   PHE   A CA  1 
ATOM   560  C C   . PHE   A 1 96  ? -2.91942  -23.86663 -45.33607 1.000 20.48022 ? 78   PHE   A C   1 
ATOM   561  O O   . PHE   A 1 96  ? -2.39240  -24.39857 -46.32519 1.000 21.61612 ? 78   PHE   A O   1 
ATOM   562  C CB  . PHE   A 1 96  ? -5.07583  -22.90193 -46.16592 1.000 22.07818 ? 78   PHE   A CB  1 
ATOM   563  C CG  . PHE   A 1 96  ? -5.99717  -23.66772 -45.27280 1.000 26.20453 ? 78   PHE   A CG  1 
ATOM   564  C CD1 . PHE   A 1 96  ? -6.83802  -23.00409 -44.39652 1.000 20.03447 ? 78   PHE   A CD1 1 
ATOM   565  C CD2 . PHE   A 1 96  ? -5.99681  -25.05360 -45.27887 1.000 19.67434 ? 78   PHE   A CD2 1 
ATOM   566  C CE1 . PHE   A 1 96  ? -7.66257  -23.70571 -43.54640 1.000 16.22180 ? 78   PHE   A CE1 1 
ATOM   567  C CE2 . PHE   A 1 96  ? -6.82348  -25.76256 -44.43807 1.000 20.05654 ? 78   PHE   A CE2 1 
ATOM   568  C CZ  . PHE   A 1 96  ? -7.66022  -25.08996 -43.56664 1.000 22.53111 ? 78   PHE   A CZ  1 
ATOM   569  N N   . PRO   A 1 97  ? -2.80549  -24.38708 -44.12003 1.000 18.24694 ? 79   PRO   A N   1 
ATOM   570  C CA  . PRO   A 1 97  ? -2.13037  -25.68365 -43.93979 1.000 19.67136 ? 79   PRO   A CA  1 
ATOM   571  C C   . PRO   A 1 97  ? -3.08431  -26.85459 -44.13369 1.000 16.65435 ? 79   PRO   A C   1 
ATOM   572  O O   . PRO   A 1 97  ? -4.10165  -26.96339 -43.44006 1.000 17.68083 ? 79   PRO   A O   1 
ATOM   573  C CB  . PRO   A 1 97  ? -1.59457  -25.59034 -42.50779 1.000 17.68077 ? 79   PRO   A CB  1 
ATOM   574  C CG  . PRO   A 1 97  ? -2.64674  -24.74955 -41.78409 1.000 20.51825 ? 79   PRO   A CG  1 
ATOM   575  C CD  . PRO   A 1 97  ? -3.22168  -23.78930 -42.83409 1.000 22.67136 ? 79   PRO   A CD  1 
ATOM   576  N N   . VAL   A 1 98  ? -2.79088  -27.73207 -45.09843 1.000 18.14366 ? 80   VAL   A N   1 
ATOM   577  C CA  . VAL   A 1 98  ? -3.71740  -28.81807 -45.40543 1.000 19.71945 ? 80   VAL   A CA  1 
ATOM   578  C C   . VAL   A 1 98  ? -3.87823  -29.71268 -44.18602 1.000 19.72831 ? 80   VAL   A C   1 
ATOM   579  O O   . VAL   A 1 98  ? -2.89451  -30.09436 -43.54010 1.000 18.98612 ? 80   VAL   A O   1 
ATOM   580  C CB  . VAL   A 1 98  ? -3.22694  -29.62350 -46.61845 1.000 25.19577 ? 80   VAL   A CB  1 
ATOM   581  C CG1 . VAL   A 1 98  ? -4.11736  -30.84479 -46.83165 1.000 20.48002 ? 80   VAL   A CG1 1 
ATOM   582  C CG2 . VAL   A 1 98  ? -3.17497  -28.74050 -47.85679 1.000 23.85692 ? 80   VAL   A CG2 1 
ATOM   583  N N   . ALA   A 1 99  ? -5.12488  -30.03061 -43.84879 1.000 22.13448 ? 81   ALA   A N   1 
ATOM   584  C CA  . ALA   A 1 99  ? -5.43588  -30.90956 -42.72311 1.000 23.55276 ? 81   ALA   A CA  1 
ATOM   585  C C   . ALA   A 1 99  ? -5.85229  -32.26481 -43.27786 1.000 26.32654 ? 81   ALA   A C   1 
ATOM   586  O O   . ALA   A 1 99  ? -7.00271  -32.45649 -43.68011 1.000 25.46285 ? 81   ALA   A O   1 
ATOM   587  C CB  . ALA   A 1 99  ? -6.52567  -30.30735 -41.84636 1.000 20.06013 ? 81   ALA   A CB  1 
ATOM   588  N N   . ASP   A 1 100 ? -4.90932  -33.20589 -43.29768 1.000 28.59225 ? 82   ASP   A N   1 
ATOM   589  C CA  . ASP   A 1 100 ? -5.19250  -34.55193 -43.77839 1.000 22.33693 ? 82   ASP   A CA  1 
ATOM   590  C C   . ASP   A 1 100 ? -6.01310  -35.33085 -42.76023 1.000 20.00984 ? 82   ASP   A C   1 
ATOM   591  O O   . ASP   A 1 100 ? -5.91942  -35.11168 -41.55137 1.000 25.20724 ? 82   ASP   A O   1 
ATOM   592  C CB  . ASP   A 1 100 ? -3.89311  -35.30806 -44.06370 1.000 20.18368 ? 82   ASP   A CB  1 
ATOM   593  C CG  . ASP   A 1 100 ? -3.11185  -34.71590 -45.20738 1.000 31.12159 ? 82   ASP   A CG  1 
ATOM   594  O OD1 . ASP   A 1 100 ? -3.68666  -34.54579 -46.30511 1.000 28.46567 ? 82   ASP   A OD1 1 
ATOM   595  O OD2 . ASP   A 1 100 ? -1.92075  -34.41013 -44.99916 1.000 35.29671 ? 82   ASP   A OD2 1 
ATOM   596  N N   . LEU   A 1 101 ? -6.83063  -36.25425 -43.26456 1.000 24.26860 ? 83   LEU   A N   1 
ATOM   597  C CA  . LEU   A 1 101 ? -7.54686  -37.15499 -42.36898 1.000 25.27706 ? 83   LEU   A CA  1 
ATOM   598  C C   . LEU   A 1 101 ? -6.57616  -37.95196 -41.51100 1.000 24.84881 ? 83   LEU   A C   1 
ATOM   599  O O   . LEU   A 1 101 ? -6.80861  -38.14390 -40.31303 1.000 27.73351 ? 83   LEU   A O   1 
ATOM   600  C CB  . LEU   A 1 101 ? -8.44425  -38.09656 -43.17226 1.000 24.29524 ? 83   LEU   A CB  1 
ATOM   601  C CG  . LEU   A 1 101 ? -9.12927  -39.19571 -42.35342 1.000 31.95335 ? 83   LEU   A CG  1 
ATOM   602  C CD1 . LEU   A 1 101 ? -9.98587  -38.59441 -41.25320 1.000 24.41815 ? 83   LEU   A CD1 1 
ATOM   603  C CD2 . LEU   A 1 101 ? -9.95168  -40.11943 -43.23972 1.000 31.23298 ? 83   LEU   A CD2 1 
ATOM   604  N N   . SER   A 1 102 ? -5.47259  -38.41046 -42.10446 1.000 22.02415 ? 84   SER   A N   1 
ATOM   605  C CA  . SER   A 1 102 ? -4.51360  -39.21689 -41.35617 1.000 31.66961 ? 84   SER   A CA  1 
ATOM   606  C C   . SER   A 1 102 ? -3.98514  -38.46725 -40.13849 1.000 30.00997 ? 84   SER   A C   1 
ATOM   607  O O   . SER   A 1 102 ? -3.87623  -39.03871 -39.04604 1.000 30.61726 ? 84   SER   A O   1 
ATOM   608  C CB  . SER   A 1 102 ? -3.36649  -39.64293 -42.27418 1.000 29.07373 ? 84   SER   A CB  1 
ATOM   609  O OG  . SER   A 1 102 ? -2.52414  -38.53740 -42.57757 1.000 30.15563 ? 84   SER   A OG  1 
ATOM   610  N N   . ILE   A 1 103 ? -3.67125  -37.18167 -40.29867 1.000 25.80717 ? 85   ILE   A N   1 
ATOM   611  C CA  . ILE   A 1 103 ? -3.11501  -36.41711 -39.18703 1.000 21.34238 ? 85   ILE   A CA  1 
ATOM   612  C C   . ILE   A 1 103 ? -4.17159  -36.18000 -38.11431 1.000 21.65745 ? 85   ILE   A C   1 
ATOM   613  O O   . ILE   A 1 103 ? -3.92421  -36.39108 -36.92016 1.000 22.08444 ? 85   ILE   A O   1 
ATOM   614  C CB  . ILE   A 1 103 ? -2.52313  -35.09146 -39.69324 1.000 27.86942 ? 85   ILE   A CB  1 
ATOM   615  C CG1 . ILE   A 1 103 ? -1.35885  -35.36750 -40.65239 1.000 29.74167 ? 85   ILE   A CG1 1 
ATOM   616  C CG2 . ILE   A 1 103 ? -2.09701  -34.22721 -38.51984 1.000 24.22754 ? 85   ILE   A CG2 1 
ATOM   617  C CD1 . ILE   A 1 103 ? -0.06413  -35.74531 -39.95315 1.000 30.14994 ? 85   ILE   A CD1 1 
ATOM   618  N N   . ILE   A 1 104 ? -5.36411  -35.73369 -38.52228 1.000 19.85625 ? 86   ILE   A N   1 
ATOM   619  C CA  . ILE   A 1 104 ? -6.39926  -35.36809 -37.55866 1.000 22.71343 ? 86   ILE   A CA  1 
ATOM   620  C C   . ILE   A 1 104 ? -6.95420  -36.60148 -36.85744 1.000 20.58810 ? 86   ILE   A C   1 
ATOM   621  O O   . ILE   A 1 104 ? -7.18062  -36.59013 -35.63867 1.000 20.11995 ? 86   ILE   A O   1 
ATOM   622  C CB  . ILE   A 1 104 ? -7.51424  -34.56287 -38.25484 1.000 19.46780 ? 86   ILE   A CB  1 
ATOM   623  C CG1 . ILE   A 1 104 ? -6.93580  -33.27994 -38.84845 1.000 22.45642 ? 86   ILE   A CG1 1 
ATOM   624  C CG2 . ILE   A 1 104 ? -8.66020  -34.27255 -37.29351 1.000 23.81547 ? 86   ILE   A CG2 1 
ATOM   625  C CD1 . ILE   A 1 104 ? -6.66150  -32.20081 -37.81285 1.000 23.33896 ? 86   ILE   A CD1 1 
ATOM   626  N N   . ALA   A 1 105 ? -7.19580  -37.67827 -37.61112 1.000 26.04445 ? 87   ALA   A N   1 
ATOM   627  C CA  . ALA   A 1 105 ? -7.71431  -38.90360 -37.00646 1.000 28.92024 ? 87   ALA   A CA  1 
ATOM   628  C C   . ALA   A 1 105 ? -6.72772  -39.49046 -36.00433 1.000 20.68605 ? 87   ALA   A C   1 
ATOM   629  O O   . ALA   A 1 105 ? -7.13160  -40.04517 -34.97395 1.000 22.60120 ? 87   ALA   A O   1 
ATOM   630  C CB  . ALA   A 1 105 ? -8.04430  -39.92783 -38.09249 1.000 32.11723 ? 87   ALA   A CB  1 
ATOM   631  N N   . ALA   A 1 106 ? -5.42853  -39.38450 -36.29019 1.000 27.29564 ? 88   ALA   A N   1 
ATOM   632  C CA  . ALA   A 1 106 ? -4.43032  -39.91648 -35.36913 1.000 20.03119 ? 88   ALA   A CA  1 
ATOM   633  C C   . ALA   A 1 106 ? -4.48096  -39.18264 -34.03643 1.000 24.31254 ? 88   ALA   A C   1 
ATOM   634  O O   . ALA   A 1 106 ? -4.47099  -39.80338 -32.96652 1.000 22.51102 ? 88   ALA   A O   1 
ATOM   635  C CB  . ALA   A 1 106 ? -3.03769  -39.81689 -35.99292 1.000 20.82777 ? 88   ALA   A CB  1 
ATOM   636  N N   . LEU   A 1 107 ? -4.53704  -37.85040 -34.08493 1.000 21.33072 ? 89   LEU   A N   1 
ATOM   637  C CA  . LEU   A 1 107 ? -4.65530  -37.07156 -32.85719 1.000 21.90272 ? 89   LEU   A CA  1 
ATOM   638  C C   . LEU   A 1 107 ? -5.98156  -37.34019 -32.16319 1.000 19.97019 ? 89   LEU   A C   1 
ATOM   639  O O   . LEU   A 1 107 ? -6.03405  -37.46831 -30.93416 1.000 18.71717 ? 89   LEU   A O   1 
ATOM   640  C CB  . LEU   A 1 107 ? -4.50044  -35.58619 -33.16842 1.000 22.21355 ? 89   LEU   A CB  1 
ATOM   641  C CG  . LEU   A 1 107 ? -3.14723  -35.23728 -33.79820 1.000 25.81475 ? 89   LEU   A CG  1 
ATOM   642  C CD1 . LEU   A 1 107 ? -3.13103  -33.80206 -34.30793 1.000 23.68920 ? 89   LEU   A CD1 1 
ATOM   643  C CD2 . LEU   A 1 107 ? -1.99406  -35.50486 -32.82248 1.000 28.70932 ? 89   LEU   A CD2 1 
ATOM   644  N N   . TYR   A 1 108 ? -7.06471  -37.42525 -32.93854 1.000 20.25701 ? 90   TYR   A N   1 
ATOM   645  C CA  . TYR   A 1 108 ? -8.36657  -37.75050 -32.36807 1.000 23.51389 ? 90   TYR   A CA  1 
ATOM   646  C C   . TYR   A 1 108 ? -8.32879  -39.08720 -31.64420 1.000 24.47093 ? 90   TYR   A C   1 
ATOM   647  O O   . TYR   A 1 108 ? -8.85553  -39.21359 -30.53345 1.000 21.43408 ? 90   TYR   A O   1 
ATOM   648  C CB  . TYR   A 1 108 ? -9.41901  -37.76017 -33.47457 1.000 18.40617 ? 90   TYR   A CB  1 
ATOM   649  C CG  . TYR   A 1 108 ? -10.85207 -37.98971 -33.00939 1.000 25.93051 ? 90   TYR   A CG  1 
ATOM   650  C CD1 . TYR   A 1 108 ? -11.36518 -39.27672 -32.86500 1.000 22.07896 ? 90   TYR   A CD1 1 
ATOM   651  C CD2 . TYR   A 1 108 ? -11.69525 -36.91628 -32.73292 1.000 22.18906 ? 90   TYR   A CD2 1 
ATOM   652  C CE1 . TYR   A 1 108 ? -12.68007 -39.49326 -32.45625 1.000 24.92419 ? 90   TYR   A CE1 1 
ATOM   653  C CE2 . TYR   A 1 108 ? -13.00953 -37.12555 -32.31911 1.000 21.63927 ? 90   TYR   A CE2 1 
ATOM   654  C CZ  . TYR   A 1 108 ? -13.49435 -38.41317 -32.18411 1.000 28.66623 ? 90   TYR   A CZ  1 
ATOM   655  O OH  . TYR   A 1 108 ? -14.79751 -38.61527 -31.77667 1.000 25.45165 ? 90   TYR   A OH  1 
ATOM   656  N N   . ALA   A 1 109 ? -7.70008  -40.09723 -32.25658 1.000 29.21910 ? 91   ALA   A N   1 
ATOM   657  C CA  . ALA   A 1 109 ? -7.58260  -41.40207 -31.60792 1.000 23.74255 ? 91   ALA   A CA  1 
ATOM   658  C C   . ALA   A 1 109 ? -6.73635  -41.31958 -30.34182 1.000 30.29926 ? 91   ALA   A C   1 
ATOM   659  O O   . ALA   A 1 109 ? -7.02103  -41.99946 -29.34862 1.000 24.54101 ? 91   ALA   A O   1 
ATOM   660  C CB  . ALA   A 1 109 ? -6.99111  -42.42090 -32.58359 1.000 26.59622 ? 91   ALA   A CB  1 
ATOM   661  N N   . ARG   A 1 110 ? -5.68778  -40.49531 -30.36076 1.000 25.71641 ? 92   ARG   A N   1 
ATOM   662  C CA  . ARG   A 1 110 ? -4.87678  -40.29868 -29.16516 1.000 26.27300 ? 92   ARG   A CA  1 
ATOM   663  C C   . ARG   A 1 110 ? -5.71933  -39.79083 -27.99776 1.000 27.93720 ? 92   ARG   A C   1 
ATOM   664  O O   . ARG   A 1 110 ? -5.64098  -40.32571 -26.88569 1.000 22.61908 ? 92   ARG   A O   1 
ATOM   665  C CB  . ARG   A 1 110 ? -3.74093  -39.32696 -29.47133 1.000 26.54446 ? 92   ARG   A CB  1 
ATOM   666  C CG  . ARG   A 1 110 ? -2.36731  -39.95768 -29.49843 1.000 29.51203 ? 92   ARG   A CG  1 
ATOM   667  C CD  . ARG   A 1 110 ? -1.44139  -39.14210 -30.37788 1.000 21.14326 ? 92   ARG   A CD  1 
ATOM   668  N NE  . ARG   A 1 110 ? -0.76281  -38.11712 -29.60133 1.000 24.78086 ? 92   ARG   A NE  1 
ATOM   669  C CZ  . ARG   A 1 110 ? 0.12842   -37.26820 -30.09274 1.000 33.93947 ? 92   ARG   A CZ  1 
ATOM   670  N NH1 . ARG   A 1 110 ? 0.48524   -37.30060 -31.36653 1.000 28.98736 ? 92   ARG   A NH1 1 
ATOM   671  N NH2 . ARG   A 1 110 ? 0.67665   -36.36531 -29.28434 1.000 26.99494 ? 92   ARG   A NH2 1 
ATOM   672  N N   . PHE   A 1 111 ? -6.53081  -38.74966 -28.23013 1.000 26.89411 ? 93   PHE   A N   1 
ATOM   673  C CA  . PHE   A 1 111 ? -7.37113  -38.21170 -27.16017 1.000 20.61132 ? 93   PHE   A CA  1 
ATOM   674  C C   . PHE   A 1 111 ? -8.37879  -39.24630 -26.67007 1.000 24.46457 ? 93   PHE   A C   1 
ATOM   675  O O   . PHE   A 1 111 ? -8.58189  -39.40651 -25.46099 1.000 26.18630 ? 93   PHE   A O   1 
ATOM   676  C CB  . PHE   A 1 111 ? -8.09820  -36.94521 -27.62646 1.000 21.41091 ? 93   PHE   A CB  1 
ATOM   677  C CG  . PHE   A 1 111 ? -8.99450  -36.33244 -26.56886 1.000 25.30466 ? 93   PHE   A CG  1 
ATOM   678  C CD1 . PHE   A 1 111 ? -8.47652  -35.49439 -25.59619 1.000 26.36601 ? 93   PHE   A CD1 1 
ATOM   679  C CD2 . PHE   A 1 111 ? -10.35379 -36.60573 -26.54564 1.000 25.70401 ? 93   PHE   A CD2 1 
ATOM   680  C CE1 . PHE   A 1 111 ? -9.29466  -34.93050 -24.62205 1.000 27.08489 ? 93   PHE   A CE1 1 
ATOM   681  C CE2 . PHE   A 1 111 ? -11.17876 -36.05174 -25.56716 1.000 25.07988 ? 93   PHE   A CE2 1 
ATOM   682  C CZ  . PHE   A 1 111 ? -10.64320 -35.20579 -24.60771 1.000 20.40175 ? 93   PHE   A CZ  1 
ATOM   683  N N   . THR   A 1 112 ? -9.03970  -39.94362 -27.59435 1.000 26.48469 ? 94   THR   A N   1 
ATOM   684  C CA  . THR   A 1 112 ? -10.08843 -40.87298 -27.18124 1.000 30.37415 ? 94   THR   A CA  1 
ATOM   685  C C   . THR   A 1 112 ? -9.50496  -42.06281 -26.42733 1.000 25.48196 ? 94   THR   A C   1 
ATOM   686  O O   . THR   A 1 112 ? -10.02111 -42.44946 -25.37209 1.000 29.61676 ? 94   THR   A O   1 
ATOM   687  C CB  . THR   A 1 112 ? -10.90496 -41.33227 -28.38924 1.000 25.22531 ? 94   THR   A CB  1 
ATOM   688  O OG1 . THR   A 1 112 ? -10.02765 -41.83733 -29.40179 1.000 46.95255 ? 94   THR   A OG1 1 
ATOM   689  C CG2 . THR   A 1 112 ? -11.68969 -40.16128 -28.95578 1.000 24.83978 ? 94   THR   A CG2 1 
ATOM   690  N N   . ALA   A 1 113 ? -8.41850  -42.64880 -26.93970 1.000 29.16531 ? 95   ALA   A N   1 
ATOM   691  C CA  . ALA   A 1 113 ? -7.75909  -43.72287 -26.19901 1.000 32.70833 ? 95   ALA   A CA  1 
ATOM   692  C C   . ALA   A 1 113 ? -7.41118  -43.26979 -24.78779 1.000 35.33909 ? 95   ALA   A C   1 
ATOM   693  O O   . ALA   A 1 113 ? -7.62542  -44.00758 -23.81871 1.000 31.27356 ? 95   ALA   A O   1 
ATOM   694  C CB  . ALA   A 1 113 ? -6.50660  -44.19313 -26.94416 1.000 33.92298 ? 95   ALA   A CB  1 
ATOM   695  N N   . GLN   A 1 114 ? -6.92052  -42.03284 -24.64978 1.000 31.08558 ? 96   GLN   A N   1 
ATOM   696  C CA  . GLN   A 1 114 ? -6.56716  -41.50768 -23.33404 1.000 25.67343 ? 96   GLN   A CA  1 
ATOM   697  C C   . GLN   A 1 114 ? -7.78684  -41.39141 -22.42699 1.000 34.11913 ? 96   GLN   A C   1 
ATOM   698  O O   . GLN   A 1 114 ? -7.77130  -41.86244 -21.28294 1.000 32.72179 ? 96   GLN   A O   1 
ATOM   699  C CB  . GLN   A 1 114 ? -5.88893  -40.14735 -23.47657 1.000 27.99277 ? 96   GLN   A CB  1 
ATOM   700  C CG  . GLN   A 1 114 ? -5.56547  -39.50300 -22.14269 1.000 36.83837 ? 96   GLN   A CG  1 
ATOM   701  C CD  . GLN   A 1 114 ? -4.82559  -38.18741 -22.28946 1.000 43.45537 ? 96   GLN   A CD  1 
ATOM   702  O OE1 . GLN   A 1 114 ? -4.82358  -37.57668 -23.36253 1.000 36.12967 ? 96   GLN   A OE1 1 
ATOM   703  N NE2 . GLN   A 1 114 ? -4.20286  -37.73513 -21.20435 1.000 41.52527 ? 96   GLN   A NE2 1 
ATOM   704  N N   . ILE   A 1 115 ? -8.85044  -40.74353 -22.90810 1.000 30.18343 ? 97   ILE   A N   1 
ATOM   705  C CA  . ILE   A 1 115 ? -10.01641 -40.51777 -22.05476 1.000 25.11228 ? 97   ILE   A CA  1 
ATOM   706  C C   . ILE   A 1 115 ? -10.75763 -41.82407 -21.79693 1.000 36.10555 ? 97   ILE   A C   1 
ATOM   707  O O   . ILE   A 1 115 ? -11.12338 -42.13306 -20.65674 1.000 34.80180 ? 97   ILE   A O   1 
ATOM   708  C CB  . ILE   A 1 115 ? -10.94811 -39.46189 -22.67355 1.000 31.03462 ? 97   ILE   A CB  1 
ATOM   709  C CG1 . ILE   A 1 115 ? -10.20266 -38.14740 -22.87856 1.000 29.96564 ? 97   ILE   A CG1 1 
ATOM   710  C CG2 . ILE   A 1 115 ? -12.15018 -39.24297 -21.77313 1.000 37.16183 ? 97   ILE   A CG2 1 
ATOM   711  C CD1 . ILE   A 1 115 ? -9.39348  -37.71131 -21.67319 1.000 28.40000 ? 97   ILE   A CD1 1 
ATOM   712  N N   . ARG   A 1 116 ? -11.00334 -42.60215 -22.85458 1.000 32.97853 ? 98   ARG   A N   1 
ATOM   713  C CA  . ARG   A 1 116 ? -11.76921 -43.83457 -22.70095 1.000 35.34283 ? 98   ARG   A CA  1 
ATOM   714  C C   . ARG   A 1 116 ? -11.07715 -44.80847 -21.75750 1.000 36.19589 ? 98   ARG   A C   1 
ATOM   715  O O   . ARG   A 1 116 ? -11.74618 -45.58159 -21.06422 1.000 42.02014 ? 98   ARG   A O   1 
ATOM   716  C CB  . ARG   A 1 116 ? -11.99838 -44.47771 -24.07085 1.000 34.47794 ? 98   ARG   A CB  1 
ATOM   717  C CG  . ARG   A 1 116 ? -12.94798 -43.68453 -24.97405 1.000 42.73975 ? 98   ARG   A CG  1 
ATOM   718  C CD  . ARG   A 1 116 ? -14.25951 -44.41251 -25.20593 1.000 45.36141 ? 98   ARG   A CD  1 
ATOM   719  N NE  . ARG   A 1 116 ? -14.91751 -44.76168 -23.95249 1.000 59.61757 ? 98   ARG   A NE  1 
ATOM   720  C CZ  . ARG   A 1 116 ? -16.07218 -45.40819 -23.86565 1.000 58.11228 ? 98   ARG   A CZ  1 
ATOM   721  N NH1 . ARG   A 1 116 ? -16.75578 -45.75452 -24.94636 1.000 60.16490 ? 98   ARG   A NH1 1 
ATOM   722  N NH2 . ARG   A 1 116 ? -16.55084 -45.71951 -22.66515 1.000 49.65631 ? 98   ARG   A NH2 1 
ATOM   723  N N   . GLY   A 1 117 ? -9.74424  -44.76741 -21.69180 1.000 38.72166 ? 99   GLY   A N   1 
ATOM   724  C CA  . GLY   A 1 117 ? -9.02554  -45.69870 -20.84074 1.000 40.54005 ? 99   GLY   A CA  1 
ATOM   725  C C   . GLY   A 1 117 ? -9.01869  -45.33129 -19.37317 1.000 45.92500 ? 99   GLY   A C   1 
ATOM   726  O O   . GLY   A 1 117 ? -8.99547  -46.21927 -18.51426 1.000 42.94019 ? 99   GLY   A O   1 
ATOM   727  N N   . ALA   A 1 118 ? -9.04509  -44.03572 -19.05793 1.000 40.45974 ? 100  ALA   A N   1 
ATOM   728  C CA  . ALA   A 1 118 ? -8.84743  -43.57217 -17.68961 1.000 40.05663 ? 100  ALA   A CA  1 
ATOM   729  C C   . ALA   A 1 118 ? -10.12529 -43.53095 -16.85691 1.000 32.50461 ? 100  ALA   A C   1 
ATOM   730  O O   . ALA   A 1 118 ? -10.04874 -43.24854 -15.65677 1.000 37.87504 ? 100  ALA   A O   1 
ATOM   731  C CB  . ALA   A 1 118 ? -8.20640  -42.18084 -17.69723 1.000 46.57204 ? 100  ALA   A CB  1 
ATOM   732  N N   . VAL   A 1 119 ? -11.28690 -43.79540 -17.45060 1.000 42.88163 ? 101  VAL   A N   1 
ATOM   733  C CA  . VAL   A 1 119 ? -12.55647 -43.83805 -16.73149 1.000 48.37073 ? 101  VAL   A CA  1 
ATOM   734  C C   . VAL   A 1 119 ? -13.30617 -45.09069 -17.16170 1.000 43.75784 ? 101  VAL   A C   1 
ATOM   735  O O   . VAL   A 1 119 ? -13.37208 -45.39830 -18.35727 1.000 45.58431 ? 101  VAL   A O   1 
ATOM   736  C CB  . VAL   A 1 119 ? -13.41717 -42.58354 -16.99399 1.000 51.57753 ? 101  VAL   A CB  1 
ATOM   737  C CG1 . VAL   A 1 119 ? -14.71453 -42.64510 -16.19547 1.000 47.44203 ? 101  VAL   A CG1 1 
ATOM   738  C CG2 . VAL   A 1 119 ? -12.64659 -41.31148 -16.66006 1.000 41.59047 ? 101  VAL   A CG2 1 
ATOM   739  N N   . ASP   A 1 120 ? -13.86734 -45.81005 -16.19455 1.000 47.89564 ? 102  ASP   A N   1 
ATOM   740  C CA  . ASP   A 1 120 ? -14.71285 -46.96500 -16.46744 1.000 64.56418 ? 102  ASP   A CA  1 
ATOM   741  C C   . ASP   A 1 120 ? -16.15823 -46.59235 -16.16979 1.000 56.95163 ? 102  ASP   A C   1 
ATOM   742  O O   . ASP   A 1 120 ? -16.48661 -46.21148 -15.04039 1.000 57.82896 ? 102  ASP   A O   1 
ATOM   743  C CB  . ASP   A 1 120 ? -14.28437 -48.17917 -15.64462 1.000 71.87701 ? 102  ASP   A CB  1 
ATOM   744  C CG  . ASP   A 1 120 ? -14.64636 -49.48680 -16.31839 1.000 71.00478 ? 102  ASP   A CG  1 
ATOM   745  O OD1 . ASP   A 1 120 ? -15.45494 -49.45805 -17.27255 1.000 68.85691 ? 102  ASP   A OD1 1 
ATOM   746  O OD2 . ASP   A 1 120 ? -14.11267 -50.53768 -15.90632 1.000 70.50344 ? 102  ASP   A OD2 1 
ATOM   747  N N   . LEU   A 1 121 ? -17.01365 -46.70875 -17.17911 1.000 59.04896 ? 103  LEU   A N   1 
ATOM   748  C CA  . LEU   A 1 121 ? -18.38509 -46.23368 -17.07679 1.000 52.17325 ? 103  LEU   A CA  1 
ATOM   749  C C   . LEU   A 1 121 ? -19.30361 -47.27709 -16.45073 1.000 50.94023 ? 103  LEU   A C   1 
ATOM   750  O O   . LEU   A 1 121 ? -20.04960 -46.97375 -15.52141 1.000 43.89973 ? 103  LEU   A O   1 
ATOM   751  C CB  . LEU   A 1 121 ? -18.90305 -45.82976 -18.45795 1.000 50.10989 ? 103  LEU   A CB  1 
ATOM   752  C CG  . LEU   A 1 121 ? -18.17208 -44.63746 -19.08481 1.000 47.04172 ? 103  LEU   A CG  1 
ATOM   753  C CD1 . LEU   A 1 121 ? -18.57322 -44.45211 -20.54356 1.000 30.54500 ? 103  LEU   A CD1 1 
ATOM   754  C CD2 . LEU   A 1 121 ? -18.40808 -43.36339 -18.28148 1.000 37.93840 ? 103  LEU   A CD2 1 
ATOM   755  N N   . GLY   A 1 129 ? -30.11756 -40.37466 -17.11199 1.000 52.67368 ? 111  GLY   A N   1 
ATOM   756  C CA  . GLY   A 1 129 ? -29.01883 -39.84336 -17.90058 1.000 55.07091 ? 111  GLY   A CA  1 
ATOM   757  C C   . GLY   A 1 129 ? -28.31707 -38.70618 -17.18767 1.000 42.78288 ? 111  GLY   A C   1 
ATOM   758  O O   . GLY   A 1 129 ? -28.04812 -37.65787 -17.77244 1.000 55.83955 ? 111  GLY   A O   1 
ATOM   759  N N   . VAL   A 1 130 ? -28.01408 -38.92582 -15.91258 1.000 31.05161 ? 112  VAL   A N   1 
ATOM   760  C CA  . VAL   A 1 130 ? -27.48814 -37.89621 -15.02712 1.000 40.67992 ? 112  VAL   A CA  1 
ATOM   761  C C   . VAL   A 1 130 ? -26.12513 -38.34363 -14.51741 1.000 42.42812 ? 112  VAL   A C   1 
ATOM   762  O O   . VAL   A 1 130 ? -25.98415 -39.45039 -13.98412 1.000 34.35135 ? 112  VAL   A O   1 
ATOM   763  C CB  . VAL   A 1 130 ? -28.45679 -37.61526 -13.86228 1.000 45.31211 ? 112  VAL   A CB  1 
ATOM   764  C CG1 . VAL   A 1 130 ? -27.70832 -37.13958 -12.61973 1.000 43.36249 ? 112  VAL   A CG1 1 
ATOM   765  C CG2 . VAL   A 1 130 ? -29.50975 -36.60373 -14.29314 1.000 40.08288 ? 112  VAL   A CG2 1 
ATOM   766  N N   . SER   A 1 131 ? -25.12654 -37.48522 -14.68639 1.000 36.96109 ? 113  SER   A N   1 
ATOM   767  C CA  . SER   A 1 131 ? -23.78544 -37.75520 -14.19997 1.000 28.79853 ? 113  SER   A CA  1 
ATOM   768  C C   . SER   A 1 131 ? -23.67740 -37.31632 -12.74690 1.000 29.30760 ? 113  SER   A C   1 
ATOM   769  O O   . SER   A 1 131 ? -24.23838 -36.28859 -12.35789 1.000 32.36700 ? 113  SER   A O   1 
ATOM   770  C CB  . SER   A 1 131 ? -22.75716 -37.01311 -15.05329 1.000 26.74143 ? 113  SER   A CB  1 
ATOM   771  O OG  . SER   A 1 131 ? -22.88885 -37.36526 -16.41983 1.000 40.00117 ? 113  SER   A OG  1 
ATOM   772  N N   . SER   A 1 132 ? -22.94829 -38.09145 -11.94695 1.000 26.77326 ? 114  SER   A N   1 
ATOM   773  C CA  . SER   A 1 132 ? -22.77009 -37.74565 -10.54519 1.000 23.95629 ? 114  SER   A CA  1 
ATOM   774  C C   . SER   A 1 132 ? -21.58153 -36.80927 -10.37087 1.000 25.66500 ? 114  SER   A C   1 
ATOM   775  O O   . SER   A 1 132 ? -20.72248 -36.68039 -11.24668 1.000 30.34829 ? 114  SER   A O   1 
ATOM   776  C CB  . SER   A 1 132 ? -22.54205 -38.98932 -9.69190  1.000 28.80536 ? 114  SER   A CB  1 
ATOM   777  O OG  . SER   A 1 132 ? -21.39433 -39.67553 -10.15551 1.000 25.92983 ? 114  SER   A OG  1 
ATOM   778  N N   . ARG   A 1 133 ? -21.53582 -36.17206 -9.20033  1.000 26.96960 ? 115  ARG   A N   1 
ATOM   779  C CA  . ARG   A 1 133 ? -20.40933 -35.31379 -8.85992  1.000 27.86355 ? 115  ARG   A CA  1 
ATOM   780  C C   . ARG   A 1 133 ? -19.10351 -36.09616 -8.86076  1.000 31.97779 ? 115  ARG   A C   1 
ATOM   781  O O   . ARG   A 1 133 ? -18.07292 -35.60553 -9.33927  1.000 24.25693 ? 115  ARG   A O   1 
ATOM   782  C CB  . ARG   A 1 133 ? -20.65059 -34.66778 -7.49641  1.000 23.13586 ? 115  ARG   A CB  1 
ATOM   783  C CG  . ARG   A 1 133 ? -19.75055 -33.49965 -7.24080  1.000 29.96771 ? 115  ARG   A CG  1 
ATOM   784  C CD  . ARG   A 1 133 ? -19.99335 -32.85302 -5.89512  1.000 22.68907 ? 115  ARG   A CD  1 
ATOM   785  N NE  . ARG   A 1 133 ? -19.36890 -31.53938 -5.88819  1.000 29.14834 ? 115  ARG   A NE  1 
ATOM   786  C CZ  . ARG   A 1 133 ? -19.75954 -30.51144 -6.63137  1.000 24.63226 ? 115  ARG   A CZ  1 
ATOM   787  N NH1 . ARG   A 1 133 ? -20.91715 -30.51960 -7.27395  1.000 25.53452 ? 115  ARG   A NH1 1 
ATOM   788  N NH2 . ARG   A 1 133 ? -18.97716 -29.43788 -6.71323  1.000 26.53167 ? 115  ARG   A NH2 1 
ATOM   789  N N   . GLU   A 1 134 ? -19.13250 -37.32042 -8.33130  1.000 30.84976 ? 116  GLU   A N   1 
ATOM   790  C CA  . GLU   A 1 134 ? -17.93761 -38.15564 -8.29558  1.000 27.80638 ? 116  GLU   A CA  1 
ATOM   791  C C   . GLU   A 1 134 ? -17.39685 -38.41465 -9.70113  1.000 32.10248 ? 116  GLU   A C   1 
ATOM   792  O O   . GLU   A 1 134 ? -16.18080 -38.34915 -9.92989  1.000 25.44123 ? 116  GLU   A O   1 
ATOM   793  C CB  . GLU   A 1 134 ? -18.26943 -39.46077 -7.56581  1.000 31.97597 ? 116  GLU   A CB  1 
ATOM   794  C CG  . GLU   A 1 134 ? -17.62123 -40.70793 -8.12177  1.000 42.86678 ? 116  GLU   A CG  1 
ATOM   795  C CD  . GLU   A 1 134 ? -17.99016 -41.94384 -7.31888  1.000 44.24326 ? 116  GLU   A CD  1 
ATOM   796  O OE1 . GLU   A 1 134 ? -18.65378 -41.79164 -6.26604  1.000 42.77841 ? 116  GLU   A OE1 1 
ATOM   797  O OE2 . GLU   A 1 134 ? -17.61693 -43.05695 -7.74563  1.000 45.58159 ? 116  GLU   A OE2 1 
ATOM   798  N N   . LEU   A 1 135 ? -18.28902 -38.67810 -10.66247 1.000 22.95582 ? 117  LEU   A N   1 
ATOM   799  C CA  . LEU   A 1 135 ? -17.85826 -38.93621 -12.03378 1.000 31.61316 ? 117  LEU   A CA  1 
ATOM   800  C C   . LEU   A 1 135 ? -17.29164 -37.68164 -12.68921 1.000 26.41775 ? 117  LEU   A C   1 
ATOM   801  O O   . LEU   A 1 135 ? -16.26228 -37.74242 -13.37135 1.000 24.34621 ? 117  LEU   A O   1 
ATOM   802  C CB  . LEU   A 1 135 ? -19.03012 -39.47687 -12.85735 1.000 29.32642 ? 117  LEU   A CB  1 
ATOM   803  C CG  . LEU   A 1 135 ? -18.80397 -39.75108 -14.35247 1.000 28.81929 ? 117  LEU   A CG  1 
ATOM   804  C CD1 . LEU   A 1 135 ? -17.53112 -40.58147 -14.63533 1.000 25.78011 ? 117  LEU   A CD1 1 
ATOM   805  C CD2 . LEU   A 1 135 ? -20.02899 -40.40176 -14.98511 1.000 23.27811 ? 117  LEU   A CD2 1 
ATOM   806  N N   . VAL   A 1 136 ? -17.96441 -36.54142 -12.51990 1.000 23.74935 ? 118  VAL   A N   1 
ATOM   807  C CA  . VAL   A 1 136 ? -17.49406 -35.30784 -13.14533 1.000 21.35008 ? 118  VAL   A CA  1 
ATOM   808  C C   . VAL   A 1 136 ? -16.11894 -34.94169 -12.61075 1.000 22.70699 ? 118  VAL   A C   1 
ATOM   809  O O   . VAL   A 1 136 ? -15.22122 -34.55709 -13.37096 1.000 21.05773 ? 118  VAL   A O   1 
ATOM   810  C CB  . VAL   A 1 136 ? -18.51316 -34.17148 -12.92257 1.000 25.67826 ? 118  VAL   A CB  1 
ATOM   811  C CG1 . VAL   A 1 136 ? -17.94337 -32.83081 -13.39471 1.000 20.91605 ? 118  VAL   A CG1 1 
ATOM   812  C CG2 . VAL   A 1 136 ? -19.82093 -34.48709 -13.63134 1.000 24.69040 ? 118  VAL   A CG2 1 
ATOM   813  N N   . LYS   A 1 137 ? -15.92361 -35.07377 -11.29650 1.000 18.47926 ? 119  LYS   A N   1 
ATOM   814  C CA  . LYS   A 1 137 ? -14.60330 -34.83159 -10.72627 1.000 26.83491 ? 119  LYS   A CA  1 
ATOM   815  C C   . LYS   A 1 137 ? -13.56119 -35.77946 -11.31400 1.000 24.30510 ? 119  LYS   A C   1 
ATOM   816  O O   . LYS   A 1 137 ? -12.40734 -35.38486 -11.52839 1.000 21.69491 ? 119  LYS   A O   1 
ATOM   817  C CB  . LYS   A 1 137 ? -14.65652 -34.96132 -9.20501  1.000 22.31297 ? 119  LYS   A CB  1 
ATOM   818  C CG  . LYS   A 1 137 ? -14.89272 -33.64573 -8.49571  1.000 23.60222 ? 119  LYS   A CG  1 
ATOM   819  C CD  . LYS   A 1 137 ? -15.01002 -33.82042 -6.98969  1.000 26.00102 ? 119  LYS   A CD  1 
ATOM   820  C CE  . LYS   A 1 137 ? -13.71232 -34.30784 -6.39563  1.000 30.00571 ? 119  LYS   A CE  1 
ATOM   821  N NZ  . LYS   A 1 137 ? -13.46875 -33.71264 -5.05837  1.000 37.45301 ? 119  LYS   A NZ  1 
ATOM   822  N N   . LYS   A 1 138 ? -13.95317 -37.03046 -11.58934 1.000 24.56781 ? 120  LYS   A N   1 
ATOM   823  C CA  . LYS   A 1 138 ? -13.02352 -38.01404 -12.14607 1.000 26.06199 ? 120  LYS   A CA  1 
ATOM   824  C C   . LYS   A 1 138 ? -12.52551 -37.58994 -13.52117 1.000 24.97822 ? 120  LYS   A C   1 
ATOM   825  O O   . LYS   A 1 138 ? -11.32580 -37.66086 -13.81060 1.000 21.47820 ? 120  LYS   A O   1 
ATOM   826  C CB  . LYS   A 1 138 ? -13.70077 -39.38342 -12.25423 1.000 27.48897 ? 120  LYS   A CB  1 
ATOM   827  C CG  . LYS   A 1 138 ? -13.57414 -40.30491 -11.05805 1.000 38.38883 ? 120  LYS   A CG  1 
ATOM   828  C CD  . LYS   A 1 138 ? -14.02507 -41.71442 -11.47062 1.000 47.42004 ? 120  LYS   A CD  1 
ATOM   829  C CE  . LYS   A 1 138 ? -14.46442 -42.56262 -10.28767 1.000 41.20267 ? 120  LYS   A CE  1 
ATOM   830  N NZ  . LYS   A 1 138 ? -14.01641 -41.97283 -9.00413  1.000 45.98163 ? 120  LYS   A NZ  1 
ATOM   831  N N   . VAL   A 1 139 ? -13.44805 -37.19520 -14.40050 1.000 19.51196 ? 121  VAL   A N   1 
ATOM   832  C CA  . VAL   A 1 139 ? -13.06801 -36.75605 -15.73569 1.000 21.10725 ? 121  VAL   A CA  1 
ATOM   833  C C   . VAL   A 1 139 ? -12.24970 -35.47371 -15.65729 1.000 21.72444 ? 121  VAL   A C   1 
ATOM   834  O O   . VAL   A 1 139 ? -11.24619 -35.31130 -16.36485 1.000 23.66334 ? 121  VAL   A O   1 
ATOM   835  C CB  . VAL   A 1 139 ? -14.32072 -36.57271 -16.60749 1.000 16.05539 ? 121  VAL   A CB  1 
ATOM   836  C CG1 . VAL   A 1 139 ? -13.93946 -36.05508 -17.98597 1.000 20.87205 ? 121  VAL   A CG1 1 
ATOM   837  C CG2 . VAL   A 1 139 ? -15.09494 -37.88240 -16.70755 1.000 17.39962 ? 121  VAL   A CG2 1 
ATOM   838  N N   . SER   A 1 140 ? -12.67448 -34.53824 -14.80559 1.000 18.26962 ? 122  SER   A N   1 
ATOM   839  C CA  . SER   A 1 140 ? -11.91154 -33.31078 -14.59922 1.000 21.54645 ? 122  SER   A CA  1 
ATOM   840  C C   . SER   A 1 140 ? -10.48462 -33.61578 -14.15075 1.000 20.23278 ? 122  SER   A C   1 
ATOM   841  O O   . SER   A 1 140 ? -9.52252  -33.01061 -14.64687 1.000 20.06317 ? 122  SER   A O   1 
ATOM   842  C CB  . SER   A 1 140 ? -12.63142 -32.43641 -13.57012 1.000 21.00411 ? 122  SER   A CB  1 
ATOM   843  O OG  . SER   A 1 140 ? -11.80019 -31.37582 -13.13228 1.000 23.81930 ? 122  SER   A OG  1 
ATOM   844  N N   . ASP   A 1 141 ? -10.33091 -34.56996 -13.22681 1.000 18.96590 ? 123  ASP   A N   1 
ATOM   845  C CA  . ASP   A 1 141 ? -9.00567  -34.94530 -12.73737 1.000 26.44932 ? 123  ASP   A CA  1 
ATOM   846  C C   . ASP   A 1 141 ? -8.14088  -35.54421 -13.84357 1.000 21.07284 ? 123  ASP   A C   1 
ATOM   847  O O   . ASP   A 1 141 ? -6.91486  -35.36443 -13.85100 1.000 20.05939 ? 123  ASP   A O   1 
ATOM   848  C CB  . ASP   A 1 141 ? -9.14645  -35.93448 -11.57435 1.000 27.27733 ? 123  ASP   A CB  1 
ATOM   849  C CG  . ASP   A 1 141 ? -9.55799  -35.25810 -10.27812 1.000 38.00955 ? 123  ASP   A CG  1 
ATOM   850  O OD1 . ASP   A 1 141 ? -9.75541  -34.02114 -10.28184 1.000 30.69385 ? 123  ASP   A OD1 1 
ATOM   851  O OD2 . ASP   A 1 141 ? -9.71313  -35.96876 -9.25999  1.000 36.88562 ? 123  ASP   A OD2 1 
ATOM   852  N N   . VAL   A 1 142 ? -8.75345  -36.27929 -14.77202 1.000 23.95268 ? 124  VAL   A N   1 
ATOM   853  C CA  . VAL   A 1 142 ? -7.99380  -36.86193 -15.87686 1.000 24.28702 ? 124  VAL   A CA  1 
ATOM   854  C C   . VAL   A 1 142 ? -7.33799  -35.76210 -16.69967 1.000 25.49977 ? 124  VAL   A C   1 
ATOM   855  O O   . VAL   A 1 142 ? -6.14138  -35.81869 -17.01010 1.000 29.35765 ? 124  VAL   A O   1 
ATOM   856  C CB  . VAL   A 1 142 ? -8.89945  -37.75481 -16.74505 1.000 20.44613 ? 124  VAL   A CB  1 
ATOM   857  C CG1 . VAL   A 1 142 ? -8.20486  -38.10755 -18.04969 1.000 21.93695 ? 124  VAL   A CG1 1 
ATOM   858  C CG2 . VAL   A 1 142 ? -9.27614  -39.03111 -15.98666 1.000 21.60947 ? 124  VAL   A CG2 1 
ATOM   859  N N   . ILE   A 1 143 ? -8.11464  -34.73799 -17.05684 1.000 18.26271 ? 125  ILE   A N   1 
ATOM   860  C CA  . ILE   A 1 143 ? -7.56983  -33.58950 -17.77634 1.000 20.20650 ? 125  ILE   A CA  1 
ATOM   861  C C   . ILE   A 1 143 ? -6.49527  -32.90565 -16.94070 1.000 16.69818 ? 125  ILE   A C   1 
ATOM   862  O O   . ILE   A 1 143 ? -5.34309  -32.75907 -17.36830 1.000 16.51080 ? 125  ILE   A O   1 
ATOM   863  C CB  . ILE   A 1 143 ? -8.69578  -32.60485 -18.14159 1.000 20.73244 ? 125  ILE   A CB  1 
ATOM   864  C CG1 . ILE   A 1 143 ? -9.76243  -33.30092 -19.00126 1.000 21.89828 ? 125  ILE   A CG1 1 
ATOM   865  C CG2 . ILE   A 1 143 ? -8.11963  -31.37061 -18.83727 1.000 16.21340 ? 125  ILE   A CG2 1 
ATOM   866  C CD1 . ILE   A 1 143 ? -9.25399  -33.86796 -20.29262 1.000 17.60588 ? 125  ILE   A CD1 1 
ATOM   867  N N   . TRP   A 1 144 ? -6.86606  -32.49989 -15.72243 1.000 16.87152 ? 126  TRP   A N   1 
ATOM   868  C CA  . TRP   A 1 144 ? -5.97438  -31.76275 -14.83157 1.000 17.67814 ? 126  TRP   A CA  1 
ATOM   869  C C   . TRP   A 1 144 ? -4.62649  -32.45442 -14.67821 1.000 20.79514 ? 126  TRP   A C   1 
ATOM   870  O O   . TRP   A 1 144 ? -3.56817  -31.83338 -14.82608 1.000 17.78346 ? 126  TRP   A O   1 
ATOM   871  C CB  . TRP   A 1 144 ? -6.65553  -31.61113 -13.47217 1.000 17.93128 ? 126  TRP   A CB  1 
ATOM   872  C CG  . TRP   A 1 144 ? -6.01188  -30.66555 -12.53045 1.000 20.05581 ? 126  TRP   A CG  1 
ATOM   873  C CD1 . TRP   A 1 144 ? -5.34944  -30.97804 -11.37817 1.000 22.55534 ? 126  TRP   A CD1 1 
ATOM   874  C CD2 . TRP   A 1 144 ? -6.00525  -29.23768 -12.62364 1.000 21.33215 ? 126  TRP   A CD2 1 
ATOM   875  N NE1 . TRP   A 1 144 ? -4.92283  -29.83118 -10.75372 1.000 21.49043 ? 126  TRP   A NE1 1 
ATOM   876  C CE2 . TRP   A 1 144 ? -5.31267  -28.74961 -11.49785 1.000 19.06852 ? 126  TRP   A CE2 1 
ATOM   877  C CE3 . TRP   A 1 144 ? -6.51429  -28.32402 -13.55285 1.000 19.68738 ? 126  TRP   A CE3 1 
ATOM   878  C CZ2 . TRP   A 1 144 ? -5.10986  -27.39417 -11.27822 1.000 18.51270 ? 126  TRP   A CZ2 1 
ATOM   879  C CZ3 . TRP   A 1 144 ? -6.31805  -26.97573 -13.32853 1.000 20.46879 ? 126  TRP   A CZ3 1 
ATOM   880  C CH2 . TRP   A 1 144 ? -5.61718  -26.52393 -12.19687 1.000 19.99574 ? 126  TRP   A CH2 1 
ATOM   881  N N   . ASN   A 1 145 ? -4.64365  -33.75133 -14.39665 1.000 21.85553 ? 127  ASN   A N   1 
ATOM   882  C CA  . ASN   A 1 145 ? -3.39489  -34.43560 -14.10614 1.000 21.27195 ? 127  ASN   A CA  1 
ATOM   883  C C   . ASN   A 1 145 ? -2.59589  -34.77986 -15.35607 1.000 25.71448 ? 127  ASN   A C   1 
ATOM   884  O O   . ASN   A 1 145 ? -1.44556  -35.20372 -15.23129 1.000 25.12911 ? 127  ASN   A O   1 
ATOM   885  C CB  . ASN   A 1 145 ? -3.68444  -35.68686 -13.28366 1.000 23.08819 ? 127  ASN   A CB  1 
ATOM   886  C CG  . ASN   A 1 145 ? -4.25454  -35.35444 -11.91497 1.000 22.76298 ? 127  ASN   A CG  1 
ATOM   887  O OD1 . ASN   A 1 145 ? -5.29391  -35.87409 -11.52141 1.000 33.08478 ? 127  ASN   A OD1 1 
ATOM   888  N ND2 . ASN   A 1 145 ? -3.57903  -34.47111 -11.19040 1.000 28.46906 ? 127  ASN   A ND2 1 
ATOM   889  N N   . SER   A 1 146 ? -3.15836  -34.59257 -16.54982 1.000 22.49474 ? 128  SER   A N   1 
ATOM   890  C CA  . SER   A 1 146 ? -2.39709  -34.78213 -17.77903 1.000 20.12530 ? 128  SER   A CA  1 
ATOM   891  C C   . SER   A 1 146 ? -1.55237  -33.56859 -18.13769 1.000 26.09628 ? 128  SER   A C   1 
ATOM   892  O O   . SER   A 1 146 ? -0.63109  -33.69073 -18.95404 1.000 20.77491 ? 128  SER   A O   1 
ATOM   893  C CB  . SER   A 1 146 ? -3.34095  -35.08121 -18.94836 1.000 23.68731 ? 128  SER   A CB  1 
ATOM   894  O OG  . SER   A 1 146 ? -4.01891  -36.30791 -18.75850 1.000 33.83861 ? 128  SER   A OG  1 
ATOM   895  N N   . LEU   A 1 147 ? -1.85322  -32.40638 -17.55930 1.000 21.26649 ? 129  LEU   A N   1 
ATOM   896  C CA  . LEU   A 1 147 ? -1.22958  -31.15173 -17.96220 1.000 22.97325 ? 129  LEU   A CA  1 
ATOM   897  C C   . LEU   A 1 147 ? 0.20047   -31.06098 -17.45417 1.000 22.90688 ? 129  LEU   A C   1 
ATOM   898  O O   . LEU   A 1 147 ? 0.54561   -31.60419 -16.39705 1.000 18.56297 ? 129  LEU   A O   1 
ATOM   899  C CB  . LEU   A 1 147 ? -2.02603  -29.95981 -17.42991 1.000 11.93658 ? 129  LEU   A CB  1 
ATOM   900  C CG  . LEU   A 1 147 ? -3.46099  -29.76899 -17.92338 1.000 24.11013 ? 129  LEU   A CG  1 
ATOM   901  C CD1 . LEU   A 1 147 ? -4.13275  -28.61671 -17.18506 1.000 22.33530 ? 129  LEU   A CD1 1 
ATOM   902  C CD2 . LEU   A 1 147 ? -3.49850  -29.51800 -19.44344 1.000 18.85737 ? 129  LEU   A CD2 1 
ATOM   903  N N   . SER   A 1 148 ? 1.02960   -30.34713 -18.21544 1.000 20.07810 ? 130  SER   A N   1 
ATOM   904  C CA  . SER   A 1 148 ? 2.38238   -30.05177 -17.76647 1.000 22.32851 ? 130  SER   A CA  1 
ATOM   905  C C   . SER   A 1 148 ? 2.33246   -29.33411 -16.42617 1.000 26.89323 ? 130  SER   A C   1 
ATOM   906  O O   . SER   A 1 148 ? 1.40411   -28.57388 -16.13865 1.000 20.99277 ? 130  SER   A O   1 
ATOM   907  C CB  . SER   A 1 148 ? 3.12395   -29.19639 -18.79659 1.000 20.39296 ? 130  SER   A CB  1 
ATOM   908  O OG  . SER   A 1 148 ? 3.19821   -29.86045 -20.04997 1.000 27.05730 ? 130  SER   A OG  1 
ATOM   909  N N   . ARG   A 1 149 ? 3.34081   -29.59627 -15.59299 1.000 18.30835 ? 131  ARG   A N   1 
ATOM   910  C CA  . ARG   A 1 149 ? 3.35575   -29.04206 -14.24418 1.000 23.34321 ? 131  ARG   A CA  1 
ATOM   911  C C   . ARG   A 1 149 ? 3.74642   -27.57276 -14.23392 1.000 27.24412 ? 131  ARG   A C   1 
ATOM   912  O O   . ARG   A 1 149 ? 3.37018   -26.84591 -13.30799 1.000 26.88383 ? 131  ARG   A O   1 
ATOM   913  C CB  . ARG   A 1 149 ? 4.31681   -29.83919 -13.35218 1.000 31.76976 ? 131  ARG   A CB  1 
ATOM   914  N N   . SER   A 1 150 ? 4.48630   -27.11583 -15.24281 1.000 17.92684 ? 132  SER   A N   1 
ATOM   915  C CA  . SER   A 1 150 ? 5.02665   -25.76010 -15.24622 1.000 29.65051 ? 132  SER   A CA  1 
ATOM   916  C C   . SER   A 1 150 ? 4.96047   -25.20291 -16.66155 1.000 21.41971 ? 132  SER   A C   1 
ATOM   917  O O   . SER   A 1 150 ? 5.73278   -25.61235 -17.53315 1.000 30.43544 ? 132  SER   A O   1 
ATOM   918  C CB  . SER   A 1 150 ? 6.46396   -25.74851 -14.71504 1.000 37.33284 ? 132  SER   A CB  1 
ATOM   919  O OG  . SER   A 1 150 ? 7.15460   -24.57953 -15.11881 1.000 46.75046 ? 132  SER   A OG  1 
ATOM   920  N N   . TYR   A 1 151 ? 4.02892   -24.28234 -16.89292 1.000 24.16112 ? 133  TYR   A N   1 
ATOM   921  C CA  . TYR   A 1 151 ? 3.99798   -23.51411 -18.12969 1.000 23.88457 ? 133  TYR   A CA  1 
ATOM   922  C C   . TYR   A 1 151 ? 3.30130   -22.19627 -17.84291 1.000 17.63921 ? 133  TYR   A C   1 
ATOM   923  O O   . TYR   A 1 151 ? 2.69398   -22.01015 -16.78949 1.000 22.05172 ? 133  TYR   A O   1 
ATOM   924  C CB  . TYR   A 1 151 ? 3.30570   -24.26813 -19.26908 1.000 18.54131 ? 133  TYR   A CB  1 
ATOM   925  C CG  . TYR   A 1 151 ? 1.85763   -24.66420 -19.01256 1.000 22.27269 ? 133  TYR   A CG  1 
ATOM   926  C CD1 . TYR   A 1 151 ? 1.54837   -25.82815 -18.31754 1.000 22.38515 ? 133  TYR   A CD1 1 
ATOM   927  C CD2 . TYR   A 1 151 ? 0.80662   -23.88461 -19.49083 1.000 14.92591 ? 133  TYR   A CD2 1 
ATOM   928  C CE1 . TYR   A 1 151 ? 0.24223   -26.20288 -18.09883 1.000 19.88156 ? 133  TYR   A CE1 1 
ATOM   929  C CE2 . TYR   A 1 151 ? -0.50900  -24.25293 -19.28162 1.000 14.22376 ? 133  TYR   A CE2 1 
ATOM   930  C CZ  . TYR   A 1 151 ? -0.78065  -25.41563 -18.58374 1.000 11.00626 ? 133  TYR   A CZ  1 
ATOM   931  O OH  . TYR   A 1 151 ? -2.07387  -25.79767 -18.36401 1.000 11.06399 ? 133  TYR   A OH  1 
ATOM   932  N N   . PHE   A 1 152 ? 3.41806   -21.27133 -18.78379 1.000 19.81440 ? 134  PHE   A N   1 
ATOM   933  C CA  . PHE   A 1 152 ? 2.81656   -19.95898 -18.60377 1.000 21.99089 ? 134  PHE   A CA  1 
ATOM   934  C C   . PHE   A 1 152 ? 1.35686   -20.05367 -19.00794 1.000 19.21372 ? 134  PHE   A C   1 
ATOM   935  O O   . PHE   A 1 152 ? 1.04132   -20.24756 -20.18298 1.000 18.26872 ? 134  PHE   A O   1 
ATOM   936  C CB  . PHE   A 1 152 ? 3.59184   -18.92126 -19.40254 1.000 22.68834 ? 134  PHE   A CB  1 
ATOM   937  C CG  . PHE   A 1 152 ? 4.88210   -18.54754 -18.75172 1.000 27.35989 ? 134  PHE   A CG  1 
ATOM   938  C CD1 . PHE   A 1 152 ? 4.88853   -18.03206 -17.46091 1.000 30.08608 ? 134  PHE   A CD1 1 
ATOM   939  C CD2 . PHE   A 1 152 ? 6.08701   -18.79753 -19.37944 1.000 26.47275 ? 134  PHE   A CD2 1 
ATOM   940  C CE1 . PHE   A 1 152 ? 6.08116   -17.70874 -16.83002 1.000 28.59273 ? 134  PHE   A CE1 1 
ATOM   941  C CE2 . PHE   A 1 152 ? 7.29035   -18.48465 -18.75020 1.000 28.29856 ? 134  PHE   A CE2 1 
ATOM   942  C CZ  . PHE   A 1 152 ? 7.28249   -17.94105 -17.47491 1.000 30.87812 ? 134  PHE   A CZ  1 
ATOM   943  N N   . LYS   A 1 153 ? 0.46961   -19.95085 -18.02138 1.000 24.74579 ? 135  LYS   A N   1 
ATOM   944  C CA  . LYS   A 1 153 ? -0.94435  -20.22861 -18.23530 1.000 30.99278 ? 135  LYS   A CA  1 
ATOM   945  C C   . LYS   A 1 153 ? -1.61357  -19.19130 -19.12668 1.000 21.57272 ? 135  LYS   A C   1 
ATOM   946  O O   . LYS   A 1 153 ? -2.70589  -19.45241 -19.63853 1.000 25.13637 ? 135  LYS   A O   1 
ATOM   947  C CB  . LYS   A 1 153 ? -1.67716  -20.32263 -16.88615 1.000 33.05978 ? 135  LYS   A CB  1 
ATOM   948  C CG  . LYS   A 1 153 ? -1.02507  -21.16871 -15.74873 1.000 43.02996 ? 135  LYS   A CG  1 
ATOM   949  C CD  . LYS   A 1 153 ? -0.13211  -22.31970 -16.23867 1.000 39.94069 ? 135  LYS   A CD  1 
ATOM   950  C CE  . LYS   A 1 153 ? -0.02341  -23.50490 -15.25053 1.000 27.89898 ? 135  LYS   A CE  1 
ATOM   951  N NZ  . LYS   A 1 153 ? 1.23085   -23.45979 -14.39931 1.000 27.67535 ? 135  LYS   A NZ  1 
ATOM   952  N N   . ASP   A 1 154 ? -0.98898  -18.03299 -19.33847 1.000 21.06623 ? 136  ASP   A N   1 
ATOM   953  C CA  . ASP   A 1 154 ? -1.59622  -16.97145 -20.12381 1.000 19.39612 ? 136  ASP   A CA  1 
ATOM   954  C C   . ASP   A 1 154 ? -1.05309  -16.87546 -21.54794 1.000 19.46650 ? 136  ASP   A C   1 
ATOM   955  O O   . ASP   A 1 154 ? -1.31249  -15.87313 -22.22284 1.000 17.70553 ? 136  ASP   A O   1 
ATOM   956  C CB  . ASP   A 1 154 ? -1.44992  -15.62104 -19.40375 1.000 20.43409 ? 136  ASP   A CB  1 
ATOM   957  C CG  . ASP   A 1 154 ? 0.00631   -15.19190 -19.18067 1.000 31.76142 ? 136  ASP   A CG  1 
ATOM   958  O OD1 . ASP   A 1 154 ? 0.95574   -15.92929 -19.52240 1.000 24.96226 ? 136  ASP   A OD1 1 
ATOM   959  O OD2 . ASP   A 1 154 ? 0.20018   -14.07939 -18.63916 1.000 34.60991 ? 136  ASP   A OD2 1 
ATOM   960  N N   . ARG   A 1 155 ? -0.32221  -17.88402 -22.02685 1.000 14.55998 ? 137  ARG   A N   1 
ATOM   961  C CA  . ARG   A 1 155 ? 0.16446   -17.83906 -23.39949 1.000 15.08755 ? 137  ARG   A CA  1 
ATOM   962  C C   . ARG   A 1 155 ? -0.98314  -17.98606 -24.38699 1.000 20.01962 ? 137  ARG   A C   1 
ATOM   963  O O   . ARG   A 1 155 ? -2.03297  -18.56188 -24.08559 1.000 14.05611 ? 137  ARG   A O   1 
ATOM   964  C CB  . ARG   A 1 155 ? 1.17941   -18.94815 -23.69990 1.000 23.72755 ? 137  ARG   A CB  1 
ATOM   965  C CG  . ARG   A 1 155 ? 2.21741   -19.22066 -22.65154 1.000 33.33012 ? 137  ARG   A CG  1 
ATOM   966  C CD  . ARG   A 1 155 ? 3.48522   -19.79539 -23.26070 1.000 30.91220 ? 137  ARG   A CD  1 
ATOM   967  N NE  . ARG   A 1 155 ? 3.22134   -20.69637 -24.37909 1.000 30.15974 ? 137  ARG   A NE  1 
ATOM   968  C CZ  . ARG   A 1 155 ? 3.62155   -21.95938 -24.44616 1.000 34.73634 ? 137  ARG   A CZ  1 
ATOM   969  N NH1 . ARG   A 1 155 ? 4.25911   -22.53961 -23.44133 1.000 36.94427 ? 137  ARG   A NH1 1 
ATOM   970  N NH2 . ARG   A 1 155 ? 3.38714   -22.65458 -25.55419 1.000 24.86708 ? 137  ARG   A NH2 1 
ATOM   971  N N   . ALA   A 1 156 ? -0.75320  -17.47268 -25.58976 1.000 14.39101 ? 138  ALA   A N   1 
ATOM   972  C CA  . ALA   A 1 156 ? -1.67453  -17.64902 -26.69831 1.000 12.74355 ? 138  ALA   A CA  1 
ATOM   973  C C   . ALA   A 1 156 ? -1.55005  -19.05576 -27.27015 1.000 16.56041 ? 138  ALA   A C   1 
ATOM   974  O O   . ALA   A 1 156 ? -0.50955  -19.70911 -27.14536 1.000 14.19833 ? 138  ALA   A O   1 
ATOM   975  C CB  . ALA   A 1 156 ? -1.39091  -16.62370 -27.80086 1.000 16.26170 ? 138  ALA   A CB  1 
ATOM   976  N N   . HIS   A 1 157 ? -2.63698  -19.51922 -27.89192 1.000 13.67012 ? 139  HIS   A N   1 
ATOM   977  C CA  . HIS   A 1 157 ? -2.64721  -20.73596 -28.70239 1.000 15.16755 ? 139  HIS   A CA  1 
ATOM   978  C C   . HIS   A 1 157 ? -2.51021  -22.00027 -27.86747 1.000 14.68066 ? 139  HIS   A C   1 
ATOM   979  O O   . HIS   A 1 157 ? -2.04202  -23.02721 -28.36835 1.000 17.31786 ? 139  HIS   A O   1 
ATOM   980  C CB  . HIS   A 1 157 ? -1.55713  -20.70665 -29.77667 1.000 15.86251 ? 139  HIS   A CB  1 
ATOM   981  C CG  . HIS   A 1 157 ? -1.44992  -19.39681 -30.49164 1.000 15.54606 ? 139  HIS   A CG  1 
ATOM   982  N ND1 . HIS   A 1 157 ? -2.51046  -18.82803 -31.16417 1.000 15.41585 ? 139  HIS   A ND1 1 
ATOM   983  C CD2 . HIS   A 1 157 ? -0.40544  -18.54902 -30.64585 1.000 16.84562 ? 139  HIS   A CD2 1 
ATOM   984  C CE1 . HIS   A 1 157 ? -2.12655  -17.67781 -31.69023 1.000 14.58758 ? 139  HIS   A CE1 1 
ATOM   985  N NE2 . HIS   A 1 157 ? -0.85150  -17.48741 -31.39403 1.000 15.42584 ? 139  HIS   A NE2 1 
ATOM   986  N N   . ILE   A 1 158 ? -2.92033  -21.95743 -26.60037 1.000 11.85323 ? 140  ILE   A N   1 
ATOM   987  C CA  . ILE   A 1 158 ? -3.01394  -23.18007 -25.79948 1.000 13.03152 ? 140  ILE   A CA  1 
ATOM   988  C C   . ILE   A 1 158 ? -4.45135  -23.35413 -25.32173 1.000 10.87909 ? 140  ILE   A C   1 
ATOM   989  O O   . ILE   A 1 158 ? -4.69614  -23.76409 -24.18308 1.000 12.32623 ? 140  ILE   A O   1 
ATOM   990  C CB  . ILE   A 1 158 ? -2.02071  -23.16080 -24.61844 1.000 14.86485 ? 140  ILE   A CB  1 
ATOM   991  C CG1 . ILE   A 1 158 ? -2.19492  -21.89146 -23.76141 1.000 12.37278 ? 140  ILE   A CG1 1 
ATOM   992  C CG2 . ILE   A 1 158 ? -0.59535  -23.24067 -25.13087 1.000 15.40980 ? 140  ILE   A CG2 1 
ATOM   993  C CD1 . ILE   A 1 158 ? -1.72111  -22.06536 -22.31760 1.000 15.63448 ? 140  ILE   A CD1 1 
ATOM   994  N N   . GLN   A 1 159 ? -5.41382  -23.05040 -26.19443 1.000 14.68152 ? 141  GLN   A N   1 
ATOM   995  C CA  . GLN   A 1 159 ? -6.82888  -23.13574 -25.84934 1.000 11.12500 ? 141  GLN   A CA  1 
ATOM   996  C C   . GLN   A 1 159 ? -7.48514  -24.43308 -26.30535 1.000 12.74934 ? 141  GLN   A C   1 
ATOM   997  O O   . GLN   A 1 159 ? -8.50945  -24.82150 -25.73324 1.000 12.82442 ? 141  GLN   A O   1 
ATOM   998  C CB  . GLN   A 1 159 ? -7.60124  -21.94742 -26.45195 1.000 10.50557 ? 141  GLN   A CB  1 
ATOM   999  C CG  . GLN   A 1 159 ? -7.83318  -22.00351 -27.97920 1.000 8.57156  ? 141  GLN   A CG  1 
ATOM   1000 C CD  . GLN   A 1 159 ? -6.62597  -21.54562 -28.79476 1.000 14.88811 ? 141  GLN   A CD  1 
ATOM   1001 O OE1 . GLN   A 1 159 ? -5.53454  -22.11604 -28.69476 1.000 12.00549 ? 141  GLN   A OE1 1 
ATOM   1002 N NE2 . GLN   A 1 159 ? -6.82319  -20.52104 -29.62077 1.000 10.78353 ? 141  GLN   A NE2 1 
ATOM   1003 N N   . SER   A 1 160 ? -6.91278  -25.11667 -27.28933 1.000 11.02327 ? 142  SER   A N   1 
ATOM   1004 C CA  . SER   A 1 160 ? -7.60608  -26.15668 -28.03772 1.000 14.08892 ? 142  SER   A CA  1 
ATOM   1005 C C   . SER   A 1 160 ? -7.18510  -27.54501 -27.58060 1.000 13.33976 ? 142  SER   A C   1 
ATOM   1006 O O   . SER   A 1 160 ? -6.16915  -27.73228 -26.90571 1.000 13.79552 ? 142  SER   A O   1 
ATOM   1007 C CB  . SER   A 1 160 ? -7.32354  -26.01088 -29.53200 1.000 10.84961 ? 142  SER   A CB  1 
ATOM   1008 O OG  . SER   A 1 160 ? -5.95190  -26.28165 -29.79325 1.000 13.83879 ? 142  SER   A OG  1 
ATOM   1009 N N   . LEU   A 1 161 ? -7.97142  -28.54056 -27.98860 1.000 13.56227 ? 143  LEU   A N   1 
ATOM   1010 C CA  . LEU   A 1 161 ? -7.53688  -29.91006 -27.74538 1.000 18.31459 ? 143  LEU   A CA  1 
ATOM   1011 C C   . LEU   A 1 161 ? -6.30503  -30.27767 -28.55541 1.000 14.22886 ? 143  LEU   A C   1 
ATOM   1012 O O   . LEU   A 1 161 ? -5.58464  -31.19447 -28.15526 1.000 14.57910 ? 143  LEU   A O   1 
ATOM   1013 C CB  . LEU   A 1 161 ? -8.66703  -30.89546 -28.01668 1.000 14.62570 ? 143  LEU   A CB  1 
ATOM   1014 C CG  . LEU   A 1 161 ? -9.97728  -30.47919 -27.36273 1.000 18.05005 ? 143  LEU   A CG  1 
ATOM   1015 C CD1 . LEU   A 1 161 ? -11.00408 -31.45337 -27.76895 1.000 26.49338 ? 143  LEU   A CD1 1 
ATOM   1016 C CD2 . LEU   A 1 161 ? -9.83542  -30.50483 -25.86490 1.000 28.64723 ? 143  LEU   A CD2 1 
ATOM   1017 N N   . PHE   A 1 162 ? -6.03019  -29.58002 -29.66431 1.000 13.51787 ? 144  PHE   A N   1 
ATOM   1018 C CA  . PHE   A 1 162 ? -4.73869  -29.75445 -30.31893 1.000 17.12707 ? 144  PHE   A CA  1 
ATOM   1019 C C   . PHE   A 1 162 ? -3.61002  -29.42437 -29.35390 1.000 15.68037 ? 144  PHE   A C   1 
ATOM   1020 O O   . PHE   A 1 162 ? -2.64141  -30.18101 -29.23017 1.000 13.76786 ? 144  PHE   A O   1 
ATOM   1021 C CB  . PHE   A 1 162 ? -4.64096  -28.88881 -31.57366 1.000 13.78257 ? 144  PHE   A CB  1 
ATOM   1022 C CG  . PHE   A 1 162 ? -3.34998  -29.07563 -32.33694 1.000 15.68944 ? 144  PHE   A CG  1 
ATOM   1023 C CD1 . PHE   A 1 162 ? -3.22110  -30.10447 -33.26387 1.000 14.21303 ? 144  PHE   A CD1 1 
ATOM   1024 C CD2 . PHE   A 1 162 ? -2.26474  -28.23749 -32.11668 1.000 12.51203 ? 144  PHE   A CD2 1 
ATOM   1025 C CE1 . PHE   A 1 162 ? -2.03827  -30.29024 -33.96642 1.000 14.54478 ? 144  PHE   A CE1 1 
ATOM   1026 C CE2 . PHE   A 1 162 ? -1.06581  -28.42227 -32.81941 1.000 15.49159 ? 144  PHE   A CE2 1 
ATOM   1027 C CZ  . PHE   A 1 162 ? -0.95877  -29.44235 -33.74487 1.000 17.78349 ? 144  PHE   A CZ  1 
ATOM   1028 N N   . SER   A 1 163 ? -3.73428  -28.30236 -28.63944 1.000 13.57963 ? 145  SER   A N   1 
ATOM   1029 C CA  . SER   A 1 163 ? -2.72805  -27.94824 -27.64593 1.000 13.59399 ? 145  SER   A CA  1 
ATOM   1030 C C   . SER   A 1 163 ? -2.66039  -28.98745 -26.53351 1.000 13.42097 ? 145  SER   A C   1 
ATOM   1031 O O   . SER   A 1 163 ? -1.56732  -29.35035 -26.07998 1.000 15.55824 ? 145  SER   A O   1 
ATOM   1032 C CB  . SER   A 1 163 ? -3.02143  -26.56224 -27.06832 1.000 13.31726 ? 145  SER   A CB  1 
ATOM   1033 O OG  . SER   A 1 163 ? -2.08787  -26.25190 -26.04783 1.000 17.23269 ? 145  SER   A OG  1 
ATOM   1034 N N   . PHE   A 1 164 ? -3.81650  -29.48914 -26.08731 1.000 11.34541 ? 146  PHE   A N   1 
ATOM   1035 C CA  . PHE   A 1 164 ? -3.81523  -30.47958 -25.01374 1.000 16.21383 ? 146  PHE   A CA  1 
ATOM   1036 C C   . PHE   A 1 164 ? -3.13291  -31.77395 -25.45365 1.000 16.08474 ? 146  PHE   A C   1 
ATOM   1037 O O   . PHE   A 1 164 ? -2.31606  -32.32870 -24.70971 1.000 14.24667 ? 146  PHE   A O   1 
ATOM   1038 C CB  . PHE   A 1 164 ? -5.24986  -30.75138 -24.54181 1.000 15.03840 ? 146  PHE   A CB  1 
ATOM   1039 C CG  . PHE   A 1 164 ? -5.36217  -31.86167 -23.51051 1.000 11.25000 ? 146  PHE   A CG  1 
ATOM   1040 C CD1 . PHE   A 1 164 ? -5.04327  -31.62920 -22.18137 1.000 15.15931 ? 146  PHE   A CD1 1 
ATOM   1041 C CD2 . PHE   A 1 164 ? -5.80566  -33.11284 -23.86656 1.000 18.10621 ? 146  PHE   A CD2 1 
ATOM   1042 C CE1 . PHE   A 1 164 ? -5.16035  -32.64048 -21.22586 1.000 22.78249 ? 146  PHE   A CE1 1 
ATOM   1043 C CE2 . PHE   A 1 164 ? -5.91953  -34.13897 -22.91930 1.000 21.93630 ? 146  PHE   A CE2 1 
ATOM   1044 C CZ  . PHE   A 1 164 ? -5.59874  -33.89954 -21.60440 1.000 17.24430 ? 146  PHE   A CZ  1 
ATOM   1045 N N   . ILE   A 1 165 ? -3.44098  -32.26351 -26.66374 1.000 15.38629 ? 147  ILE   A N   1 
ATOM   1046 C CA  . ILE   A 1 165 ? -2.87854  -33.54411 -27.12209 1.000 20.06694 ? 147  ILE   A CA  1 
ATOM   1047 C C   . ILE   A 1 165 ? -1.39076  -33.41638 -27.40936 1.000 25.51031 ? 147  ILE   A C   1 
ATOM   1048 O O   . ILE   A 1 165 ? -0.58669  -34.25136 -26.98004 1.000 19.53330 ? 147  ILE   A O   1 
ATOM   1049 C CB  . ILE   A 1 165 ? -3.61407  -34.08546 -28.36797 1.000 19.89636 ? 147  ILE   A CB  1 
ATOM   1050 C CG1 . ILE   A 1 165 ? -5.13432  -34.11938 -28.22394 1.000 21.41845 ? 147  ILE   A CG1 1 
ATOM   1051 C CG2 . ILE   A 1 165 ? -3.08323  -35.47283 -28.74707 1.000 24.25779 ? 147  ILE   A CG2 1 
ATOM   1052 C CD1 . ILE   A 1 165 ? -5.60810  -34.42364 -26.85466 1.000 33.62063 ? 147  ILE   A CD1 1 
ATOM   1053 N N   . THR   A 1 166 ? -1.00693  -32.40549 -28.17876 1.000 17.56699 ? 148  THR   A N   1 
ATOM   1054 C CA  . THR   A 1 166 ? 0.35228   -32.33853 -28.68970 1.000 16.91120 ? 148  THR   A CA  1 
ATOM   1055 C C   . THR   A 1 166 ? 1.29799   -31.55865 -27.78798 1.000 19.86299 ? 148  THR   A C   1 
ATOM   1056 O O   . THR   A 1 166 ? 2.51037   -31.62921 -27.99374 1.000 16.97915 ? 148  THR   A O   1 
ATOM   1057 C CB  . THR   A 1 166 ? 0.35791   -31.73201 -30.10163 1.000 18.30669 ? 148  THR   A CB  1 
ATOM   1058 O OG1 . THR   A 1 166 ? 0.06281   -30.32766 -30.03381 1.000 18.96819 ? 148  THR   A OG1 1 
ATOM   1059 C CG2 . THR   A 1 166 ? -0.67205  -32.45038 -30.99054 1.000 15.95622 ? 148  THR   A CG2 1 
ATOM   1060 N N   . GLY   A 1 167 ? 0.78644   -30.85149 -26.78208 1.000 19.44084 ? 149  GLY   A N   1 
ATOM   1061 C CA  . GLY   A 1 167 ? 1.64211   -30.03899 -25.93741 1.000 20.18651 ? 149  GLY   A CA  1 
ATOM   1062 C C   . GLY   A 1 167 ? 1.35612   -30.15009 -24.45244 1.000 17.39394 ? 149  GLY   A C   1 
ATOM   1063 O O   . GLY   A 1 167 ? 2.07440   -29.55682 -23.64430 1.000 19.53247 ? 149  GLY   A O   1 
ATOM   1064 N N   . THR   A 1 168 ? 0.31846   -30.90888 -24.08647 1.000 14.22897 ? 150  THR   A N   1 
ATOM   1065 C CA  . THR   A 1 168 ? -0.11055  -31.08625 -22.68977 1.000 14.77977 ? 150  THR   A CA  1 
ATOM   1066 C C   . THR   A 1 168 ? -0.20826  -29.75426 -21.93603 1.000 20.78645 ? 150  THR   A C   1 
ATOM   1067 O O   . THR   A 1 168 ? 0.18623   -29.64555 -20.77231 1.000 15.82972 ? 150  THR   A O   1 
ATOM   1068 C CB  . THR   A 1 168 ? 0.80473   -32.06886 -21.94226 1.000 23.31538 ? 150  THR   A CB  1 
ATOM   1069 O OG1 . THR   A 1 168 ? 2.12531   -31.51960 -21.81786 1.000 17.78756 ? 150  THR   A OG1 1 
ATOM   1070 C CG2 . THR   A 1 168 ? 0.88261   -33.40600 -22.67851 1.000 23.05572 ? 150  THR   A CG2 1 
ATOM   1071 N N   . LYS   A 1 169 ? -0.74927  -28.72790 -22.60313 1.000 17.22451 ? 151  LYS   A N   1 
ATOM   1072 C CA  . LYS   A 1 169 ? -0.91245  -27.40265 -22.01263 1.000 15.91730 ? 151  LYS   A CA  1 
ATOM   1073 C C   . LYS   A 1 169 ? -2.27687  -26.84961 -22.38825 1.000 13.24002 ? 151  LYS   A C   1 
ATOM   1074 O O   . LYS   A 1 169 ? -2.68133  -26.93803 -23.55118 1.000 10.50611 ? 151  LYS   A O   1 
ATOM   1075 C CB  . LYS   A 1 169 ? 0.16534   -26.42063 -22.49664 1.000 15.67229 ? 151  LYS   A CB  1 
ATOM   1076 C CG  . LYS   A 1 169 ? 1.57724   -26.88284 -22.28472 1.000 28.26099 ? 151  LYS   A CG  1 
ATOM   1077 C CD  . LYS   A 1 169 ? 2.56862   -25.87092 -22.80732 1.000 27.80868 ? 151  LYS   A CD  1 
ATOM   1078 C CE  . LYS   A 1 169 ? 3.77242   -26.58032 -23.40479 1.000 33.37771 ? 151  LYS   A CE  1 
ATOM   1079 N NZ  . LYS   A 1 169 ? 4.21299   -27.77900 -22.63113 1.000 35.57118 ? 151  LYS   A NZ  1 
ATOM   1080 N N   . LEU   A 1 170 ? -2.97594  -26.26688 -21.40753 1.000 9.92347  ? 152  LEU   A N   1 
ATOM   1081 C CA  . LEU   A 1 170 ? -4.25014  -25.60007 -21.65316 1.000 14.33042 ? 152  LEU   A CA  1 
ATOM   1082 C C   . LEU   A 1 170 ? -4.32874  -24.31854 -20.83382 1.000 14.84458 ? 152  LEU   A C   1 
ATOM   1083 O O   . LEU   A 1 170 ? -3.83403  -24.27166 -19.70274 1.000 11.34033 ? 152  LEU   A O   1 
ATOM   1084 C CB  . LEU   A 1 170 ? -5.43345  -26.50904 -21.30159 1.000 13.25077 ? 152  LEU   A CB  1 
ATOM   1085 C CG  . LEU   A 1 170 ? -5.75541  -27.63073 -22.28882 1.000 10.50430 ? 152  LEU   A CG  1 
ATOM   1086 C CD1 . LEU   A 1 170 ? -6.84693  -28.49980 -21.70318 1.000 11.64096 ? 152  LEU   A CD1 1 
ATOM   1087 C CD2 . LEU   A 1 170 ? -6.18630  -27.04743 -23.61957 1.000 12.94082 ? 152  LEU   A CD2 1 
ATOM   1088 N N   . ASP   A 1 171 ? -4.93664  -23.27425 -21.40911 1.000 13.70290 ? 153  ASP   A N   1 
ATOM   1089 C CA  . ASP   A 1 171 ? -5.22488  -22.09098 -20.61163 1.000 15.73787 ? 153  ASP   A CA  1 
ATOM   1090 C C   . ASP   A 1 171 ? -6.42905  -22.38000 -19.71687 1.000 12.52913 ? 153  ASP   A C   1 
ATOM   1091 O O   . ASP   A 1 171 ? -7.02042  -23.46084 -19.76655 1.000 12.41978 ? 153  ASP   A O   1 
ATOM   1092 C CB  . ASP   A 1 171 ? -5.42353  -20.84868 -21.49093 1.000 12.29794 ? 153  ASP   A CB  1 
ATOM   1093 C CG  . ASP   A 1 171 ? -6.49204  -21.02019 -22.57724 1.000 11.45930 ? 153  ASP   A CG  1 
ATOM   1094 O OD1 . ASP   A 1 171 ? -7.48114  -21.75890 -22.38453 1.000 11.29201 ? 153  ASP   A OD1 1 
ATOM   1095 O OD2 . ASP   A 1 171 ? -6.35568  -20.36168 -23.64294 1.000 15.13981 ? 153  ASP   A OD2 1 
ATOM   1096 N N   . SER   A 1 172 ? -6.78456  -21.41379 -18.86672 1.000 12.35999 ? 154  SER   A N   1 
ATOM   1097 C CA  . SER   A 1 172 ? -7.71949  -21.69761 -17.78203 1.000 17.37742 ? 154  SER   A CA  1 
ATOM   1098 C C   . SER   A 1 172 ? -9.05851  -22.19440 -18.31704 1.000 13.16759 ? 154  SER   A C   1 
ATOM   1099 O O   . SER   A 1 172 ? -9.51997  -23.28408 -17.96143 1.000 11.58562 ? 154  SER   A O   1 
ATOM   1100 C CB  . SER   A 1 172 ? -7.90771  -20.45934 -16.90950 1.000 14.88198 ? 154  SER   A CB  1 
ATOM   1101 O OG  . SER   A 1 172 ? -8.94537  -20.68070 -15.97189 1.000 17.10334 ? 154  SER   A OG  1 
ATOM   1102 N N   . SER   A 1 173 ? -9.69325  -21.41768 -19.19415 1.000 10.80792 ? 155  SER   A N   1 
ATOM   1103 C CA  . SER   A 1 173 ? -10.97222 -21.86373 -19.71700 1.000 12.40450 ? 155  SER   A CA  1 
ATOM   1104 C C   . SER   A 1 173 ? -10.80914 -23.02774 -20.68432 1.000 11.05094 ? 155  SER   A C   1 
ATOM   1105 O O   . SER   A 1 173 ? -11.76070 -23.78644 -20.88081 1.000 12.96254 ? 155  SER   A O   1 
ATOM   1106 C CB  . SER   A 1 173 ? -11.72142 -20.69985 -20.38848 1.000 9.22548  ? 155  SER   A CB  1 
ATOM   1107 O OG  . SER   A 1 173 ? -11.01539 -20.19295 -21.51209 1.000 11.21382 ? 155  SER   A OG  1 
ATOM   1108 N N   . GLY   A 1 174 ? -9.61946  -23.19083 -21.27869 1.000 14.92296 ? 156  GLY   A N   1 
ATOM   1109 C CA  . GLY   A 1 174 ? -9.36708  -24.35424 -22.11441 1.000 15.00115 ? 156  GLY   A CA  1 
ATOM   1110 C C   . GLY   A 1 174 ? -9.46683  -25.66103 -21.35498 1.000 14.63397 ? 156  GLY   A C   1 
ATOM   1111 O O   . GLY   A 1 174 ? -9.89418  -26.67348 -21.91350 1.000 14.82067 ? 156  GLY   A O   1 
ATOM   1112 N N   . VAL   A 1 175 ? -9.07717  -25.65568 -20.07648 1.000 14.36830 ? 157  VAL   A N   1 
ATOM   1113 C CA  . VAL   A 1 175 ? -9.24927  -26.82452 -19.21754 1.000 17.04187 ? 157  VAL   A CA  1 
ATOM   1114 C C   . VAL   A 1 175 ? -10.72557 -27.18459 -19.10050 1.000 15.63334 ? 157  VAL   A C   1 
ATOM   1115 O O   . VAL   A 1 175 ? -11.11419 -28.35120 -19.25111 1.000 14.03131 ? 157  VAL   A O   1 
ATOM   1116 C CB  . VAL   A 1 175 ? -8.61422  -26.56650 -17.83523 1.000 19.68352 ? 157  VAL   A CB  1 
ATOM   1117 C CG1 . VAL   A 1 175 ? -8.91721  -27.71308 -16.87098 1.000 14.90511 ? 157  VAL   A CG1 1 
ATOM   1118 C CG2 . VAL   A 1 175 ? -7.10117  -26.37496 -17.96270 1.000 12.60828 ? 157  VAL   A CG2 1 
ATOM   1119 N N   . ALA   A 1 176 ? -11.57456 -26.18324 -18.84351 1.000 14.25479 ? 158  ALA   A N   1 
ATOM   1120 C CA  . ALA   A 1 176 ? -13.00593 -26.44170 -18.72468 1.000 16.06944 ? 158  ALA   A CA  1 
ATOM   1121 C C   . ALA   A 1 176 ? -13.57345 -26.99517 -20.02152 1.000 16.58394 ? 158  ALA   A C   1 
ATOM   1122 O O   . ALA   A 1 176 ? -14.36298 -27.95484 -20.00526 1.000 13.17648 ? 158  ALA   A O   1 
ATOM   1123 C CB  . ALA   A 1 176 ? -13.74989 -25.16179 -18.32318 1.000 16.54296 ? 158  ALA   A CB  1 
ATOM   1124 N N   . PHE   A 1 177 ? -13.17102 -26.41269 -21.15883 1.000 13.05928 ? 159  PHE   A N   1 
ATOM   1125 C CA  . PHE   A 1 177 ? -13.65706 -26.89897 -22.44409 1.000 12.91207 ? 159  PHE   A CA  1 
ATOM   1126 C C   . PHE   A 1 177 ? -13.21843 -28.33759 -22.69024 1.000 18.91099 ? 159  PHE   A C   1 
ATOM   1127 O O   . PHE   A 1 177 ? -13.99207 -29.15271 -23.21338 1.000 16.02492 ? 159  PHE   A O   1 
ATOM   1128 C CB  . PHE   A 1 177 ? -13.16970 -26.00434 -23.58315 1.000 13.29142 ? 159  PHE   A CB  1 
ATOM   1129 C CG  . PHE   A 1 177 ? -13.60219 -26.49067 -24.93405 1.000 16.00265 ? 159  PHE   A CG  1 
ATOM   1130 C CD1 . PHE   A 1 177 ? -14.84406 -26.13495 -25.44472 1.000 15.66115 ? 159  PHE   A CD1 1 
ATOM   1131 C CD2 . PHE   A 1 177 ? -12.78272 -27.32771 -25.67914 1.000 15.94950 ? 159  PHE   A CD2 1 
ATOM   1132 C CE1 . PHE   A 1 177 ? -15.25662 -26.59909 -26.67691 1.000 16.80426 ? 159  PHE   A CE1 1 
ATOM   1133 C CE2 . PHE   A 1 177 ? -13.18693 -27.79714 -26.90677 1.000 17.87121 ? 159  PHE   A CE2 1 
ATOM   1134 C CZ  . PHE   A 1 177 ? -14.42642 -27.43006 -27.40989 1.000 18.92911 ? 159  PHE   A CZ  1 
ATOM   1135 N N   . ALA   A 1 178 ? -11.97213 -28.66268 -22.33262 1.000 14.15939 ? 160  ALA   A N   1 
ATOM   1136 C CA  . ALA   A 1 178 ? -11.47054 -30.02093 -22.52980 1.000 16.37717 ? 160  ALA   A CA  1 
ATOM   1137 C C   . ALA   A 1 178 ? -12.23154 -31.02207 -21.67243 1.000 17.79775 ? 160  ALA   A C   1 
ATOM   1138 O O   . ALA   A 1 178 ? -12.49080 -32.15320 -22.10648 1.000 16.84814 ? 160  ALA   A O   1 
ATOM   1139 C CB  . ALA   A 1 178 ? -9.97338  -30.07024 -22.21640 1.000 15.02487 ? 160  ALA   A CB  1 
ATOM   1140 N N   . VAL   A 1 179 ? -12.58985 -30.63152 -20.44757 1.000 14.49541 ? 161  VAL   A N   1 
ATOM   1141 C CA  . VAL   A 1 179 ? -13.37295 -31.51944 -19.59109 1.000 21.53896 ? 161  VAL   A CA  1 
ATOM   1142 C C   . VAL   A 1 179 ? -14.73026 -31.79211 -20.22129 1.000 19.65446 ? 161  VAL   A C   1 
ATOM   1143 O O   . VAL   A 1 179 ? -15.19425 -32.93756 -20.26819 1.000 17.15725 ? 161  VAL   A O   1 
ATOM   1144 C CB  . VAL   A 1 179 ? -13.51431 -30.92859 -18.17674 1.000 17.79587 ? 161  VAL   A CB  1 
ATOM   1145 C CG1 . VAL   A 1 179 ? -14.53225 -31.72760 -17.36053 1.000 20.12514 ? 161  VAL   A CG1 1 
ATOM   1146 C CG2 . VAL   A 1 179 ? -12.16744 -30.90932 -17.46890 1.000 20.35085 ? 161  VAL   A CG2 1 
ATOM   1147 N N   . VAL   A 1 180 ? -15.38749 -30.73862 -20.72104 1.000 17.66272 ? 162  VAL   A N   1 
ATOM   1148 C CA  . VAL   A 1 180 ? -16.66249 -30.91763 -21.41313 1.000 16.75982 ? 162  VAL   A CA  1 
ATOM   1149 C C   . VAL   A 1 180 ? -16.48475 -31.82356 -22.62271 1.000 18.21175 ? 162  VAL   A C   1 
ATOM   1150 O O   . VAL   A 1 180 ? -17.29269 -32.72912 -22.86319 1.000 20.76669 ? 162  VAL   A O   1 
ATOM   1151 C CB  . VAL   A 1 180 ? -17.25100 -29.54987 -21.80801 1.000 17.07258 ? 162  VAL   A CB  1 
ATOM   1152 C CG1 . VAL   A 1 180 ? -18.51578 -29.72602 -22.65867 1.000 15.32792 ? 162  VAL   A CG1 1 
ATOM   1153 C CG2 . VAL   A 1 180 ? -17.54681 -28.73047 -20.56009 1.000 13.42180 ? 162  VAL   A CG2 1 
ATOM   1154 N N   . GLY   A 1 181 ? -15.41813 -31.60304 -23.39713 1.000 13.06235 ? 163  GLY   A N   1 
ATOM   1155 C CA  . GLY   A 1 181 ? -15.17366 -32.44425 -24.55312 1.000 11.97625 ? 163  GLY   A CA  1 
ATOM   1156 C C   . GLY   A 1 181 ? -14.94243 -33.89368 -24.17067 1.000 15.67052 ? 163  GLY   A C   1 
ATOM   1157 O O   . GLY   A 1 181 ? -15.45257 -34.80750 -24.82255 1.000 19.14143 ? 163  GLY   A O   1 
ATOM   1158 N N   . ALA   A 1 182 ? -14.18006 -34.12034 -23.10198 1.000 16.95680 ? 164  ALA   A N   1 
ATOM   1159 C CA  . ALA   A 1 182 ? -13.96153 -35.48002 -22.62014 1.000 20.83473 ? 164  ALA   A CA  1 
ATOM   1160 C C   . ALA   A 1 182 ? -15.26765 -36.12031 -22.16047 1.000 18.94626 ? 164  ALA   A C   1 
ATOM   1161 O O   . ALA   A 1 182 ? -15.49867 -37.31395 -22.39034 1.000 20.88963 ? 164  ALA   A O   1 
ATOM   1162 C CB  . ALA   A 1 182 ? -12.94221 -35.46725 -21.48500 1.000 17.93117 ? 164  ALA   A CB  1 
ATOM   1163 N N   . CYS   A 1 183 ? -16.13636 -35.34035 -21.51275 1.000 22.11541 ? 165  CYS   A N   1 
ATOM   1164 C CA  . CYS   A 1 183 ? -17.41829 -35.87527 -21.06453 1.000 29.74113 ? 165  CYS   A CA  1 
ATOM   1165 C C   . CYS   A 1 183 ? -18.29633 -36.26362 -22.24765 1.000 23.27490 ? 165  CYS   A C   1 
ATOM   1166 O O   . CYS   A 1 183 ? -18.96982 -37.30037 -22.21528 1.000 26.12110 ? 165  CYS   A O   1 
ATOM   1167 C CB  . CYS   A 1 183 ? -18.13125 -34.86158 -20.16665 1.000 12.40157 ? 165  CYS   A CB  1 
ATOM   1168 S SG  . CYS   A 1 183 ? -17.41874 -34.71669 -18.54534 1.000 22.46937 ? 165  CYS   A SG  1 
ATOM   1169 N N   . GLN   A 1 184 ? -18.29592 -35.45705 -23.31018 1.000 23.75807 ? 166  GLN   A N   1 
ATOM   1170 C CA  . GLN   A 1 184 ? -19.02430 -35.85464 -24.50950 1.000 22.24268 ? 166  GLN   A CA  1 
ATOM   1171 C C   . GLN   A 1 184 ? -18.46789 -37.15304 -25.07812 1.000 33.47005 ? 166  GLN   A C   1 
ATOM   1172 O O   . GLN   A 1 184 ? -19.22913 -38.05222 -25.46021 1.000 28.94729 ? 166  GLN   A O   1 
ATOM   1173 C CB  . GLN   A 1 184 ? -18.96504 -34.76352 -25.57149 1.000 19.87738 ? 166  GLN   A CB  1 
ATOM   1174 C CG  . GLN   A 1 184 ? -19.88482 -35.04025 -26.74945 1.000 20.36338 ? 166  GLN   A CG  1 
ATOM   1175 C CD  . GLN   A 1 184 ? -19.61224 -34.14644 -27.93553 1.000 21.19377 ? 166  GLN   A CD  1 
ATOM   1176 O OE1 . GLN   A 1 184 ? -18.46676 -33.80484 -28.21789 1.000 24.67951 ? 166  GLN   A OE1 1 
ATOM   1177 N NE2 . GLN   A 1 184 ? -20.67088 -33.74323 -28.63010 1.000 22.21353 ? 166  GLN   A NE2 1 
ATOM   1178 N N   . ALA   A 1 185 ? -17.13811 -37.26428 -25.14989 1.000 25.09970 ? 167  ALA   A N   1 
ATOM   1179 C CA  . ALA   A 1 185 ? -16.51280 -38.47404 -25.66864 1.000 26.20117 ? 167  ALA   A CA  1 
ATOM   1180 C C   . ALA   A 1 185 ? -16.83158 -39.69615 -24.81737 1.000 28.64696 ? 167  ALA   A C   1 
ATOM   1181 O O   . ALA   A 1 185 ? -16.75759 -40.82241 -25.31717 1.000 31.38421 ? 167  ALA   A O   1 
ATOM   1182 C CB  . ALA   A 1 185 ? -15.00013 -38.28106 -25.76384 1.000 26.48805 ? 167  ALA   A CB  1 
ATOM   1183 N N   . LEU   A 1 186 ? -17.17821 -39.50722 -23.54891 1.000 24.56800 ? 168  LEU   A N   1 
ATOM   1184 C CA  . LEU   A 1 186 ? -17.60766 -40.60950 -22.70287 1.000 22.30223 ? 168  LEU   A CA  1 
ATOM   1185 C C   . LEU   A 1 186 ? -19.12163 -40.78254 -22.67848 1.000 37.75236 ? 168  LEU   A C   1 
ATOM   1186 O O   . LEU   A 1 186 ? -19.61669 -41.63802 -21.93907 1.000 28.88648 ? 168  LEU   A O   1 
ATOM   1187 C CB  . LEU   A 1 186 ? -17.09323 -40.41705 -21.27495 1.000 26.83973 ? 168  LEU   A CB  1 
ATOM   1188 C CG  . LEU   A 1 186 ? -15.57386 -40.42314 -21.11776 1.000 27.06299 ? 168  LEU   A CG  1 
ATOM   1189 C CD1 . LEU   A 1 186 ? -15.16009 -39.80185 -19.78915 1.000 23.91021 ? 168  LEU   A CD1 1 
ATOM   1190 C CD2 . LEU   A 1 186 ? -15.03002 -41.84907 -21.25416 1.000 31.98978 ? 168  LEU   A CD2 1 
ATOM   1191 N N   . GLY   A 1 187 ? -19.86393 -39.99595 -23.45694 1.000 36.91949 ? 169  GLY   A N   1 
ATOM   1192 C CA  . GLY   A 1 187 ? -21.30633 -40.13616 -23.51118 1.000 30.67245 ? 169  GLY   A CA  1 
ATOM   1193 C C   . GLY   A 1 187 ? -22.05240 -39.47111 -22.38049 1.000 44.71745 ? 169  GLY   A C   1 
ATOM   1194 O O   . GLY   A 1 187 ? -23.20540 -39.82814 -22.11710 1.000 33.98344 ? 169  GLY   A O   1 
ATOM   1195 N N   . LEU   A 1 188 ? -21.43140 -38.50843 -21.69891 1.000 28.01417 ? 170  LEU   A N   1 
ATOM   1196 C CA  . LEU   A 1 188 ? -22.04461 -37.85749 -20.54338 1.000 27.46528 ? 170  LEU   A CA  1 
ATOM   1197 C C   . LEU   A 1 188 ? -22.76067 -36.61458 -21.06229 1.000 38.78980 ? 170  LEU   A C   1 
ATOM   1198 O O   . LEU   A 1 188 ? -22.26211 -35.48869 -20.99624 1.000 26.20786 ? 170  LEU   A O   1 
ATOM   1199 C CB  . LEU   A 1 188 ? -20.98804 -37.52707 -19.49358 1.000 22.89678 ? 170  LEU   A CB  1 
ATOM   1200 C CG  . LEU   A 1 188 ? -20.04674 -38.66159 -19.05258 1.000 30.04571 ? 170  LEU   A CG  1 
ATOM   1201 C CD1 . LEU   A 1 188 ? -19.19742 -38.23167 -17.86014 1.000 26.90752 ? 170  LEU   A CD1 1 
ATOM   1202 C CD2 . LEU   A 1 188 ? -20.79784 -39.95198 -18.73429 1.000 25.06226 ? 170  LEU   A CD2 1 
ATOM   1203 N N   . ARG   A 1 189 ? -23.95725 -36.83734 -21.60911 1.000 29.42956 ? 171  ARG   A N   1 
ATOM   1204 C CA  . ARG   A 1 189 ? -24.64217 -35.78787 -22.35303 1.000 30.86367 ? 171  ARG   A CA  1 
ATOM   1205 C C   . ARG   A 1 189 ? -25.15874 -34.66189 -21.46718 1.000 22.02226 ? 171  ARG   A C   1 
ATOM   1206 O O   . ARG   A 1 189 ? -25.54526 -33.61812 -22.00247 1.000 29.50232 ? 171  ARG   A O   1 
ATOM   1207 C CB  . ARG   A 1 189 ? -25.79893 -36.38388 -23.16366 1.000 30.72158 ? 171  ARG   A CB  1 
ATOM   1208 C CG  . ARG   A 1 189 ? -25.35322 -37.27997 -24.31293 1.000 45.47319 ? 171  ARG   A CG  1 
ATOM   1209 C CD  . ARG   A 1 189 ? -26.52981 -37.74436 -25.17615 1.000 44.32763 ? 171  ARG   A CD  1 
ATOM   1210 N NE  . ARG   A 1 189 ? -27.18213 -36.64000 -25.87224 1.000 51.11846 ? 171  ARG   A NE  1 
ATOM   1211 C CZ  . ARG   A 1 189 ? -27.64142 -36.70020 -27.11675 1.000 60.06182 ? 171  ARG   A CZ  1 
ATOM   1212 N NH1 . ARG   A 1 189 ? -27.55338 -37.80943 -27.83495 1.000 51.97986 ? 171  ARG   A NH1 1 
ATOM   1213 N NH2 . ARG   A 1 189 ? -28.20341 -35.61937 -27.65537 1.000 56.36905 ? 171  ARG   A NH2 1 
ATOM   1214 N N   . ASP   A 1 190 ? -25.16139 -34.82946 -20.14219 1.000 24.83108 ? 172  ASP   A N   1 
ATOM   1215 C CA  . ASP   A 1 190 ? -25.66450 -33.79919 -19.23748 1.000 24.50875 ? 172  ASP   A CA  1 
ATOM   1216 C C   . ASP   A 1 190 ? -24.59703 -32.81166 -18.77757 1.000 23.61165 ? 172  ASP   A C   1 
ATOM   1217 O O   . ASP   A 1 190 ? -24.93972 -31.81815 -18.12767 1.000 30.53244 ? 172  ASP   A O   1 
ATOM   1218 C CB  . ASP   A 1 190 ? -26.31441 -34.44404 -18.00355 1.000 29.45956 ? 172  ASP   A CB  1 
ATOM   1219 C CG  . ASP   A 1 190 ? -25.30556 -35.15875 -17.11161 1.000 32.91636 ? 172  ASP   A CG  1 
ATOM   1220 O OD1 . ASP   A 1 190 ? -24.50439 -35.96558 -17.64056 1.000 27.34761 ? 172  ASP   A OD1 1 
ATOM   1221 O OD2 . ASP   A 1 190 ? -25.31566 -34.91788 -15.88371 1.000 27.64302 ? 172  ASP   A OD2 1 
ATOM   1222 N N   . VAL   A 1 191 ? -23.32471 -33.04795 -19.08917 1.000 19.97883 ? 173  VAL   A N   1 
ATOM   1223 C CA  . VAL   A 1 191 ? -22.24588 -32.16218 -18.65961 1.000 17.99300 ? 173  VAL   A CA  1 
ATOM   1224 C C   . VAL   A 1 191 ? -22.05093 -31.06105 -19.69557 1.000 22.41490 ? 173  VAL   A C   1 
ATOM   1225 O O   . VAL   A 1 191 ? -21.90606 -31.33458 -20.89545 1.000 20.62294 ? 173  VAL   A O   1 
ATOM   1226 C CB  . VAL   A 1 191 ? -20.94313 -32.94668 -18.42903 1.000 20.76961 ? 173  VAL   A CB  1 
ATOM   1227 C CG1 . VAL   A 1 191 ? -19.84973 -32.00996 -17.96499 1.000 16.19853 ? 173  VAL   A CG1 1 
ATOM   1228 C CG2 . VAL   A 1 191 ? -21.16306 -34.03982 -17.38772 1.000 21.58200 ? 173  VAL   A CG2 1 
ATOM   1229 N N   . HIS   A 1 192 ? -22.02531 -29.81010 -19.23351 1.000 16.32378 ? 174  HIS   A N   1 
ATOM   1230 C CA  . HIS   A 1 192 ? -21.95417 -28.68238 -20.15099 1.000 16.77175 ? 174  HIS   A CA  1 
ATOM   1231 C C   . HIS   A 1 192 ? -21.01949 -27.60622 -19.62045 1.000 14.66035 ? 174  HIS   A C   1 
ATOM   1232 O O   . HIS   A 1 192 ? -20.74450 -27.51324 -18.42273 1.000 13.69692 ? 174  HIS   A O   1 
ATOM   1233 C CB  . HIS   A 1 192 ? -23.34200 -28.08385 -20.40375 1.000 19.34908 ? 174  HIS   A CB  1 
ATOM   1234 C CG  . HIS   A 1 192 ? -24.20603 -28.94737 -21.26315 1.000 18.74891 ? 174  HIS   A CG  1 
ATOM   1235 N ND1 . HIS   A 1 192 ? -23.97757 -29.11536 -22.61157 1.000 19.52664 ? 174  HIS   A ND1 1 
ATOM   1236 C CD2 . HIS   A 1 192 ? -25.29890 -29.68975 -20.96881 1.000 21.98346 ? 174  HIS   A CD2 1 
ATOM   1237 C CE1 . HIS   A 1 192 ? -24.88942 -29.93192 -23.11074 1.000 24.38824 ? 174  HIS   A CE1 1 
ATOM   1238 N NE2 . HIS   A 1 192 ? -25.70108 -30.29620 -22.13418 1.000 21.25659 ? 174  HIS   A NE2 1 
ATOM   1239 N N   . LEU   A 1 193 ? -20.53216 -26.79075 -20.54885 1.000 14.69818 ? 175  LEU   A N   1 
ATOM   1240 C CA  . LEU   A 1 193 ? -19.67364 -25.66518 -20.21576 1.000 14.55331 ? 175  LEU   A CA  1 
ATOM   1241 C C   . LEU   A 1 193 ? -20.50953 -24.53850 -19.61999 1.000 16.71953 ? 175  LEU   A C   1 
ATOM   1242 O O   . LEU   A 1 193 ? -21.56823 -24.19452 -20.15694 1.000 16.51500 ? 175  LEU   A O   1 
ATOM   1243 C CB  . LEU   A 1 193 ? -18.95423 -25.17971 -21.47099 1.000 14.06078 ? 175  LEU   A CB  1 
ATOM   1244 C CG  . LEU   A 1 193 ? -17.93350 -24.05680 -21.31469 1.000 13.29831 ? 175  LEU   A CG  1 
ATOM   1245 C CD1 . LEU   A 1 193 ? -16.76968 -24.49760 -20.39917 1.000 11.96251 ? 175  LEU   A CD1 1 
ATOM   1246 C CD2 . LEU   A 1 193 ? -17.43830 -23.61958 -22.67621 1.000 14.37730 ? 175  LEU   A CD2 1 
ATOM   1247 N N   . ALA   A 1 194 ? -20.04487 -23.97426 -18.50543 1.000 18.82922 ? 176  ALA   A N   1 
ATOM   1248 C CA  . ALA   A 1 194 ? -20.62137 -22.76047 -17.93997 1.000 19.97317 ? 176  ALA   A CA  1 
ATOM   1249 C C   . ALA   A 1 194 ? -19.60209 -21.64007 -18.05041 1.000 19.14263 ? 176  ALA   A C   1 
ATOM   1250 O O   . ALA   A 1 194 ? -18.42187 -21.84039 -17.74664 1.000 17.48314 ? 176  ALA   A O   1 
ATOM   1251 C CB  . ALA   A 1 194 ? -21.02803 -22.94992 -16.47707 1.000 15.63245 ? 176  ALA   A CB  1 
ATOM   1252 N N   . LEU   A 1 195 ? -20.05801 -20.46145 -18.48159 1.000 13.24766 ? 177  LEU   A N   1 
ATOM   1253 C CA  . LEU   A 1 195 ? -19.16948 -19.34361 -18.78209 1.000 16.24632 ? 177  LEU   A CA  1 
ATOM   1254 C C   . LEU   A 1 195 ? -19.70323 -18.07310 -18.14997 1.000 16.44855 ? 177  LEU   A C   1 
ATOM   1255 O O   . LEU   A 1 195 ? -20.83841 -17.67692 -18.42939 1.000 12.15820 ? 177  LEU   A O   1 
ATOM   1256 C CB  . LEU   A 1 195 ? -19.05756 -19.13737 -20.29097 1.000 15.35648 ? 177  LEU   A CB  1 
ATOM   1257 C CG  . LEU   A 1 195 ? -18.52529 -20.28318 -21.12307 1.000 24.49861 ? 177  LEU   A CG  1 
ATOM   1258 C CD1 . LEU   A 1 195 ? -18.69538 -19.91278 -22.57109 1.000 24.20810 ? 177  LEU   A CD1 1 
ATOM   1259 C CD2 . LEU   A 1 195 ? -17.04807 -20.45273 -20.77390 1.000 24.86553 ? 177  LEU   A CD2 1 
ATOM   1260 N N   . SER   A 1 196 ? -18.88421 -17.41722 -17.33720 1.000 11.94601 ? 178  SER   A N   1 
ATOM   1261 C CA  . SER   A 1 196 ? -19.14697 -16.01889 -17.02990 1.000 11.65972 ? 178  SER   A CA  1 
ATOM   1262 C C   . SER   A 1 196 ? -18.41686 -15.16713 -18.07129 1.000 17.07946 ? 178  SER   A C   1 
ATOM   1263 O O   . SER   A 1 196 ? -18.09894 -15.64511 -19.16380 1.000 11.84044 ? 178  SER   A O   1 
ATOM   1264 C CB  . SER   A 1 196 ? -18.75267 -15.71019 -15.58488 1.000 15.70374 ? 178  SER   A CB  1 
ATOM   1265 O OG  . SER   A 1 196 ? -17.34391 -15.70515 -15.40376 1.000 12.70817 ? 178  SER   A OG  1 
ATOM   1266 N N   . GLU   A 1 197 ? -18.15736 -13.89918 -17.77226 1.000 12.16958 ? 179  GLU   A N   1 
ATOM   1267 C CA  . GLU   A 1 197 ? -17.40760 -13.09431 -18.72326 1.000 11.83417 ? 179  GLU   A CA  1 
ATOM   1268 C C   . GLU   A 1 197 ? -15.89731 -13.26465 -18.58814 1.000 10.33954 ? 179  GLU   A C   1 
ATOM   1269 O O   . GLU   A 1 197 ? -15.15599 -12.73285 -19.42792 1.000 12.57788 ? 179  GLU   A O   1 
ATOM   1270 C CB  . GLU   A 1 197 ? -17.81691 -11.61874 -18.59028 1.000 9.57507  ? 179  GLU   A CB  1 
ATOM   1271 C CG  . GLU   A 1 197 ? -19.21104 -11.37479 -19.17188 1.000 11.17202 ? 179  GLU   A CG  1 
ATOM   1272 C CD  . GLU   A 1 197 ? -19.63556 -9.90528  -19.17748 1.000 12.22965 ? 179  GLU   A CD  1 
ATOM   1273 O OE1 . GLU   A 1 197 ? -19.58696 -9.26654  -18.11466 1.000 12.17551 ? 179  GLU   A OE1 1 
ATOM   1274 O OE2 . GLU   A 1 197 ? -20.06448 -9.41810  -20.24069 1.000 10.05702 ? 179  GLU   A OE2 1 
ATOM   1275 N N   . ASP   A 1 198 ? -15.42150 -14.01831 -17.58127 1.000 9.47713  ? 180  ASP   A N   1 
ATOM   1276 C CA  . ASP   A 1 198 ? -13.98417 -14.25170 -17.42566 1.000 10.45857 ? 180  ASP   A CA  1 
ATOM   1277 C C   . ASP   A 1 198 ? -13.62930 -15.58983 -16.77871 1.000 11.76397 ? 180  ASP   A C   1 
ATOM   1278 O O   . ASP   A 1 198 ? -12.43938 -15.84830 -16.57824 1.000 16.10861 ? 180  ASP   A O   1 
ATOM   1279 C CB  . ASP   A 1 198 ? -13.34744 -13.10577 -16.60100 1.000 12.46205 ? 180  ASP   A CB  1 
ATOM   1280 C CG  . ASP   A 1 198 ? -11.81632 -13.07446 -16.69299 1.000 12.95884 ? 180  ASP   A CG  1 
ATOM   1281 O OD1 . ASP   A 1 198 ? -11.28990 -13.04129 -17.82021 1.000 18.59133 ? 180  ASP   A OD1 1 
ATOM   1282 O OD2 . ASP   A 1 198 ? -11.15035 -13.09727 -15.62576 1.000 15.16360 ? 180  ASP   A OD2 1 
ATOM   1283 N N   . HIS   A 1 199 ? -14.59134 -16.44526 -16.44786 1.000 13.58106 ? 181  HIS   A N   1 
ATOM   1284 C CA  . HIS   A 1 199 ? -14.29514 -17.72561 -15.81081 1.000 15.99435 ? 181  HIS   A CA  1 
ATOM   1285 C C   . HIS   A 1 199 ? -15.17909 -18.80050 -16.43189 1.000 15.88374 ? 181  HIS   A C   1 
ATOM   1286 O O   . HIS   A 1 199 ? -16.21006 -18.50807 -17.04888 1.000 13.13160 ? 181  HIS   A O   1 
ATOM   1287 C CB  . HIS   A 1 199 ? -14.50319 -17.64737 -14.28731 1.000 13.47862 ? 181  HIS   A CB  1 
ATOM   1288 C CG  . HIS   A 1 199 ? -14.02046 -18.85237 -13.52682 1.000 13.80803 ? 181  HIS   A CG  1 
ATOM   1289 N ND1 . HIS   A 1 199 ? -12.83213 -19.49729 -13.80606 1.000 13.43476 ? 181  HIS   A ND1 1 
ATOM   1290 C CD2 . HIS   A 1 199 ? -14.57833 -19.52762 -12.49249 1.000 15.22079 ? 181  HIS   A CD2 1 
ATOM   1291 C CE1 . HIS   A 1 199 ? -12.67852 -20.51441 -12.97526 1.000 16.82148 ? 181  HIS   A CE1 1 
ATOM   1292 N NE2 . HIS   A 1 199 ? -13.72475 -20.55527 -12.16763 1.000 16.12904 ? 181  HIS   A NE2 1 
ATOM   1293 N N   . ALA   A 1 200 ? -14.75964 -20.05734 -16.26934 1.000 16.53726 ? 182  ALA   A N   1 
ATOM   1294 C CA  . ALA   A 1 200 ? -15.45288 -21.19050 -16.86464 1.000 13.22106 ? 182  ALA   A CA  1 
ATOM   1295 C C   . ALA   A 1 200 ? -15.47819 -22.34323 -15.87192 1.000 14.53388 ? 182  ALA   A C   1 
ATOM   1296 O O   . ALA   A 1 200 ? -14.53783 -22.53813 -15.10083 1.000 13.08992 ? 182  ALA   A O   1 
ATOM   1297 C CB  . ALA   A 1 200 ? -14.78144 -21.64928 -18.17416 1.000 10.99177 ? 182  ALA   A CB  1 
ATOM   1298 N N   . TRP   A 1 201 ? -16.56377 -23.10372 -15.89981 1.000 13.27357 ? 183  TRP   A N   1 
ATOM   1299 C CA  . TRP   A 1 201 ? -16.69782 -24.29044 -15.06433 1.000 14.13881 ? 183  TRP   A CA  1 
ATOM   1300 C C   . TRP   A 1 201 ? -17.67401 -25.22271 -15.77031 1.000 11.07474 ? 183  TRP   A C   1 
ATOM   1301 O O   . TRP   A 1 201 ? -17.99782 -25.02364 -16.94720 1.000 14.56553 ? 183  TRP   A O   1 
ATOM   1302 C CB  . TRP   A 1 201 ? -17.11593 -23.90010 -13.63542 1.000 12.54720 ? 183  TRP   A CB  1 
ATOM   1303 C CG  . TRP   A 1 201 ? -18.38984 -23.10479 -13.50829 1.000 11.06937 ? 183  TRP   A CG  1 
ATOM   1304 C CD1 . TRP   A 1 201 ? -19.64318 -23.60147 -13.23565 1.000 11.80302 ? 183  TRP   A CD1 1 
ATOM   1305 C CD2 . TRP   A 1 201 ? -18.54168 -21.67273 -13.60100 1.000 10.82791 ? 183  TRP   A CD2 1 
ATOM   1306 N NE1 . TRP   A 1 201 ? -20.55248 -22.57533 -13.16344 1.000 18.12773 ? 183  TRP   A NE1 1 
ATOM   1307 C CE2 . TRP   A 1 201 ? -19.90779 -21.38423 -13.38563 1.000 13.83048 ? 183  TRP   A CE2 1 
ATOM   1308 C CE3 . TRP   A 1 201 ? -17.65679 -20.61055 -13.84267 1.000 12.24798 ? 183  TRP   A CE3 1 
ATOM   1309 C CZ2 . TRP   A 1 201 ? -20.41764 -20.07392 -13.41760 1.000 15.08328 ? 183  TRP   A CZ2 1 
ATOM   1310 C CZ3 . TRP   A 1 201 ? -18.17262 -19.29738 -13.87572 1.000 12.86715 ? 183  TRP   A CZ3 1 
ATOM   1311 C CH2 . TRP   A 1 201 ? -19.53751 -19.05272 -13.67121 1.000 14.52173 ? 183  TRP   A CH2 1 
ATOM   1312 N N   . VAL   A 1 202 ? -18.15584 -26.24872 -15.06978 1.000 12.57569 ? 184  VAL   A N   1 
ATOM   1313 C CA  . VAL   A 1 202 ? -19.12634 -27.14278 -15.69193 1.000 16.12156 ? 184  VAL   A CA  1 
ATOM   1314 C C   . VAL   A 1 202 ? -20.40969 -27.15338 -14.87385 1.000 18.15206 ? 184  VAL   A C   1 
ATOM   1315 O O   . VAL   A 1 202 ? -20.40383 -26.98174 -13.65097 1.000 15.89385 ? 184  VAL   A O   1 
ATOM   1316 C CB  . VAL   A 1 202 ? -18.59105 -28.58807 -15.88671 1.000 20.60217 ? 184  VAL   A CB  1 
ATOM   1317 C CG1 . VAL   A 1 202 ? -17.17864 -28.56490 -16.49278 1.000 19.44014 ? 184  VAL   A CG1 1 
ATOM   1318 C CG2 . VAL   A 1 202 ? -18.60395 -29.36225 -14.58118 1.000 18.26797 ? 184  VAL   A CG2 1 
ATOM   1319 N N   . VAL   A 1 203 ? -21.52097 -27.32670 -15.57693 1.000 21.38302 ? 185  VAL   A N   1 
ATOM   1320 C CA  . VAL   A 1 203 ? -22.81426 -27.60679 -14.97111 1.000 22.44209 ? 185  VAL   A CA  1 
ATOM   1321 C C   . VAL   A 1 203 ? -23.25416 -28.97650 -15.45999 1.000 18.28710 ? 185  VAL   A C   1 
ATOM   1322 O O   . VAL   A 1 203 ? -22.84413 -29.42634 -16.53446 1.000 21.13577 ? 185  VAL   A O   1 
ATOM   1323 C CB  . VAL   A 1 203 ? -23.87124 -26.53336 -15.31410 1.000 16.94552 ? 185  VAL   A CB  1 
ATOM   1324 C CG1 . VAL   A 1 203 ? -23.60063 -25.27516 -14.54353 1.000 18.70583 ? 185  VAL   A CG1 1 
ATOM   1325 C CG2 . VAL   A 1 203 ? -23.88671 -26.25824 -16.81083 1.000 25.79983 ? 185  VAL   A CG2 1 
ATOM   1326 N N   . PHE   A 1 204 ? -24.07293 -29.64863 -14.65557 1.000 21.35407 ? 186  PHE   A N   1 
ATOM   1327 C CA  . PHE   A 1 204 ? -24.52655 -31.00210 -14.96121 1.000 22.80543 ? 186  PHE   A CA  1 
ATOM   1328 C C   . PHE   A 1 204 ? -25.75162 -31.30250 -14.10449 1.000 26.62155 ? 186  PHE   A C   1 
ATOM   1329 O O   . PHE   A 1 204 ? -26.26488 -30.43264 -13.39455 1.000 27.62947 ? 186  PHE   A O   1 
ATOM   1330 C CB  . PHE   A 1 204 ? -23.41576 -32.03971 -14.72450 1.000 18.50635 ? 186  PHE   A CB  1 
ATOM   1331 C CG  . PHE   A 1 204 ? -22.89477 -32.06079 -13.31460 1.000 19.67681 ? 186  PHE   A CG  1 
ATOM   1332 C CD1 . PHE   A 1 204 ? -22.00390 -31.09682 -12.86973 1.000 19.87927 ? 186  PHE   A CD1 1 
ATOM   1333 C CD2 . PHE   A 1 204 ? -23.31737 -33.04165 -12.42260 1.000 21.27678 ? 186  PHE   A CD2 1 
ATOM   1334 C CE1 . PHE   A 1 204 ? -21.53065 -31.11386 -11.56684 1.000 19.61153 ? 186  PHE   A CE1 1 
ATOM   1335 C CE2 . PHE   A 1 204 ? -22.85197 -33.06361 -11.12010 1.000 17.57904 ? 186  PHE   A CE2 1 
ATOM   1336 C CZ  . PHE   A 1 204 ? -21.95809 -32.09692 -10.69046 1.000 23.34129 ? 186  PHE   A CZ  1 
ATOM   1337 N N   . GLY   A 1 205 ? -26.22393 -32.54262 -14.17495 1.000 32.25798 ? 187  GLY   A N   1 
ATOM   1338 C CA  . GLY   A 1 205 ? -27.30713 -32.98875 -13.33417 1.000 25.09708 ? 187  GLY   A CA  1 
ATOM   1339 C C   . GLY   A 1 205 ? -28.65919 -32.89375 -14.00585 1.000 38.90178 ? 187  GLY   A C   1 
ATOM   1340 O O   . GLY   A 1 205 ? -28.78217 -32.45952 -15.15648 1.000 37.97634 ? 187  GLY   A O   1 
ATOM   1341 N N   . PRO   A 1 206 ? -29.70945 -33.31634 -13.27170 1.000 42.89257 ? 188  PRO   A N   1 
ATOM   1342 C CA  . PRO   A 1 206 ? -31.08364 -33.31222 -13.79709 1.000 50.50404 ? 188  PRO   A CA  1 
ATOM   1343 C C   . PRO   A 1 206 ? -31.44615 -32.12235 -14.67040 1.000 46.99246 ? 188  PRO   A C   1 
ATOM   1344 O O   . PRO   A 1 206 ? -31.84432 -32.29029 -15.82858 1.000 49.27443 ? 188  PRO   A O   1 
ATOM   1345 C CB  . PRO   A 1 206 ? -31.91618 -33.30855 -12.51255 1.000 47.77006 ? 188  PRO   A CB  1 
ATOM   1346 C CG  . PRO   A 1 206 ? -31.11651 -34.17661 -11.58528 1.000 45.54207 ? 188  PRO   A CG  1 
ATOM   1347 C CD  . PRO   A 1 206 ? -29.64759 -33.94221 -11.93810 1.000 37.28964 ? 188  PRO   A CD  1 
ATOM   1348 N N   . ASN   A 1 207 ? -31.31180 -30.91642 -14.12492 1.000 43.18947 ? 189  ASN   A N   1 
ATOM   1349 C CA  . ASN   A 1 207 ? -31.72822 -29.70172 -14.81168 1.000 39.05332 ? 189  ASN   A CA  1 
ATOM   1350 C C   . ASN   A 1 207 ? -30.56017 -28.74345 -14.99373 1.000 45.34145 ? 189  ASN   A C   1 
ATOM   1351 O O   . ASN   A 1 207 ? -30.75298 -27.52866 -15.08256 1.000 35.62514 ? 189  ASN   A O   1 
ATOM   1352 C CB  . ASN   A 1 207 ? -32.86341 -29.02072 -14.04743 1.000 53.90802 ? 189  ASN   A CB  1 
ATOM   1353 C CG  . ASN   A 1 207 ? -33.91234 -30.00663 -13.56235 1.000 56.24580 ? 189  ASN   A CG  1 
ATOM   1354 O OD1 . ASN   A 1 207 ? -33.89373 -30.43299 -12.40482 1.000 60.02444 ? 189  ASN   A OD1 1 
ATOM   1355 N ND2 . ASN   A 1 207 ? -34.82916 -30.37756 -14.44787 1.000 57.91314 ? 189  ASN   A ND2 1 
ATOM   1356 N N   . GLY   A 1 208 ? -29.34259 -29.27936 -15.04578 1.000 41.09472 ? 190  GLY   A N   1 
ATOM   1357 C CA  . GLY   A 1 208 ? -28.16951 -28.44072 -15.17637 1.000 39.01070 ? 190  GLY   A CA  1 
ATOM   1358 C C   . GLY   A 1 208 ? -27.91030 -27.55142 -13.98601 1.000 30.56269 ? 190  GLY   A C   1 
ATOM   1359 O O   . GLY   A 1 208 ? -27.23607 -26.52852 -14.12145 1.000 33.27658 ? 190  GLY   A O   1 
ATOM   1360 N N   . GLU   A 1 209 ? -28.42617 -27.91484 -12.81710 1.000 26.97087 ? 191  GLU   A N   1 
ATOM   1361 C CA  . GLU   A 1 209 ? -28.30972 -27.08138 -11.62983 1.000 31.43043 ? 191  GLU   A CA  1 
ATOM   1362 C C   . GLU   A 1 209 ? -27.10456 -27.43308 -10.77214 1.000 29.45239 ? 191  GLU   A C   1 
ATOM   1363 O O   . GLU   A 1 209 ? -26.77011 -26.67416 -9.85629  1.000 32.29582 ? 191  GLU   A O   1 
ATOM   1364 C CB  . GLU   A 1 209 ? -29.58979 -27.18530 -10.79748 1.000 35.63363 ? 191  GLU   A CB  1 
ATOM   1365 C CG  . GLU   A 1 209 ? -30.74152 -26.37855 -11.37885 1.000 42.83377 ? 191  GLU   A CG  1 
ATOM   1366 C CD  . GLU   A 1 209 ? -31.97192 -26.36970 -10.48923 1.000 56.85336 ? 191  GLU   A CD  1 
ATOM   1367 O OE1 . GLU   A 1 209 ? -31.87917 -26.81871 -9.32501  1.000 65.13426 ? 191  GLU   A OE1 1 
ATOM   1368 O OE2 . GLU   A 1 209 ? -33.03544 -25.91071 -10.95856 1.000 70.71985 ? 191  GLU   A OE2 1 
ATOM   1369 N N   . GLN   A 1 210 ? -26.44154 -28.54916 -11.05066 1.000 22.72727 ? 192  GLN   A N   1 
ATOM   1370 C CA  . GLN   A 1 210 ? -25.24331 -28.91573 -10.31708 1.000 25.77934 ? 192  GLN   A CA  1 
ATOM   1371 C C   . GLN   A 1 210 ? -24.04788 -28.19785 -10.93598 1.000 17.75063 ? 192  GLN   A C   1 
ATOM   1372 O O   . GLN   A 1 210 ? -24.00644 -27.97388 -12.14764 1.000 23.66198 ? 192  GLN   A O   1 
ATOM   1373 C CB  . GLN   A 1 210 ? -25.05960 -30.43345 -10.36473 1.000 26.55324 ? 192  GLN   A CB  1 
ATOM   1374 C CG  . GLN   A 1 210 ? -26.20244 -31.18791 -9.69095  1.000 26.94443 ? 192  GLN   A CG  1 
ATOM   1375 C CD  . GLN   A 1 210 ? -26.27025 -30.95158 -8.20359  1.000 29.55625 ? 192  GLN   A CD  1 
ATOM   1376 O OE1 . GLN   A 1 210 ? -25.24727 -30.88104 -7.52164  1.000 48.90673 ? 192  GLN   A OE1 1 
ATOM   1377 N NE2 . GLN   A 1 210 ? -27.48250 -30.80049 -7.69016  1.000 50.21283 ? 192  GLN   A NE2 1 
ATOM   1378 N N   . THR   A 1 211 ? -23.09016 -27.79440 -10.10297 1.000 23.23791 ? 193  THR   A N   1 
ATOM   1379 C CA  . THR   A 1 211 ? -21.93190 -27.06120 -10.60121 1.000 20.61862 ? 193  THR   A CA  1 
ATOM   1380 C C   . THR   A 1 211 ? -20.65657 -27.58697 -9.96192  1.000 20.80538 ? 193  THR   A C   1 
ATOM   1381 O O   . THR   A 1 211 ? -20.64152 -27.96342 -8.78865  1.000 20.30052 ? 193  THR   A O   1 
ATOM   1382 C CB  . THR   A 1 211 ? -22.04425 -25.54779 -10.33742 1.000 19.57678 ? 193  THR   A CB  1 
ATOM   1383 O OG1 . THR   A 1 211 ? -21.92657 -25.29312 -8.93247  1.000 17.07046 ? 193  THR   A OG1 1 
ATOM   1384 C CG2 . THR   A 1 211 ? -23.37405 -25.00805 -10.85261 1.000 20.60568 ? 193  THR   A CG2 1 
ATOM   1385 N N   . ALA   A 1 212 ? -19.57448 -27.58503 -10.74132 1.000 15.69316 ? 194  ALA   A N   1 
ATOM   1386 C CA  . ALA   A 1 212 ? -18.27293 -27.98230 -10.23409 1.000 16.22669 ? 194  ALA   A CA  1 
ATOM   1387 C C   . ALA   A 1 212 ? -17.20243 -27.10800 -10.86076 1.000 15.69548 ? 194  ALA   A C   1 
ATOM   1388 O O   . ALA   A 1 212 ? -17.18175 -26.92896 -12.08359 1.000 16.68633 ? 194  ALA   A O   1 
ATOM   1389 C CB  . ALA   A 1 212 ? -17.98819 -29.46254 -10.53501 1.000 21.11094 ? 194  ALA   A CB  1 
ATOM   1390 N N   . GLU   A 1 213 ? -16.31606 -26.57500 -10.02542 1.000 15.47248 ? 195  GLU   A N   1 
ATOM   1391 C CA  . GLU   A 1 213 ? -15.10125 -25.95464 -10.53501 1.000 17.39267 ? 195  GLU   A CA  1 
ATOM   1392 C C   . GLU   A 1 213 ? -14.17153 -27.03479 -11.08022 1.000 20.93334 ? 195  GLU   A C   1 
ATOM   1393 O O   . GLU   A 1 213 ? -13.98540 -28.08011 -10.45759 1.000 20.39110 ? 195  GLU   A O   1 
ATOM   1394 C CB  . GLU   A 1 213 ? -14.39505 -25.17647 -9.42579  1.000 15.92893 ? 195  GLU   A CB  1 
ATOM   1395 C CG  . GLU   A 1 213 ? -15.20440 -24.03932 -8.81218  1.000 20.14549 ? 195  GLU   A CG  1 
ATOM   1396 C CD  . GLU   A 1 213 ? -15.02368 -22.72605 -9.55170  1.000 20.76734 ? 195  GLU   A CD  1 
ATOM   1397 O OE1 . GLU   A 1 213 ? -14.38206 -22.72663 -10.62553 1.000 14.93008 ? 195  GLU   A OE1 1 
ATOM   1398 O OE2 . GLU   A 1 213 ? -15.53714 -21.69544 -9.06282  1.000 20.87750 ? 195  GLU   A OE2 1 
ATOM   1399 N N   . VAL   A 1 214 ? -13.57668 -26.78003 -12.24665 1.000 18.04820 ? 196  VAL   A N   1 
ATOM   1400 C CA  . VAL   A 1 214 ? -12.66640 -27.72828 -12.87886 1.000 15.36735 ? 196  VAL   A CA  1 
ATOM   1401 C C   . VAL   A 1 214 ? -11.33214 -27.10153 -13.25534 1.000 19.00615 ? 196  VAL   A C   1 
ATOM   1402 O O   . VAL   A 1 214 ? -10.43538 -27.80949 -13.72449 1.000 15.62673 ? 196  VAL   A O   1 
ATOM   1403 C CB  . VAL   A 1 214 ? -13.31043 -28.38785 -14.12010 1.000 21.73513 ? 196  VAL   A CB  1 
ATOM   1404 C CG1 . VAL   A 1 214 ? -14.60382 -29.12658 -13.75886 1.000 16.61398 ? 196  VAL   A CG1 1 
ATOM   1405 C CG2 . VAL   A 1 214 ? -13.58702 -27.34782 -15.19825 1.000 23.85689 ? 196  VAL   A CG2 1 
ATOM   1406 N N   . THR   A 1 215 ? -11.17154 -25.79321 -13.09308 1.000 14.89417 ? 197  THR   A N   1 
ATOM   1407 C CA  . THR   A 1 215 ? -9.95035  -25.13349 -13.51613 1.000 15.47435 ? 197  THR   A CA  1 
ATOM   1408 C C   . THR   A 1 215 ? -9.61643  -24.03711 -12.51388 1.000 17.75633 ? 197  THR   A C   1 
ATOM   1409 O O   . THR   A 1 215 ? -10.37175 -23.76514 -11.57918 1.000 18.76493 ? 197  THR   A O   1 
ATOM   1410 C CB  . THR   A 1 215 ? -10.09909 -24.59340 -14.94555 1.000 12.21703 ? 197  THR   A CB  1 
ATOM   1411 O OG1 . THR   A 1 215 ? -8.80967  -24.25934 -15.47064 1.000 13.02011 ? 197  THR   A OG1 1 
ATOM   1412 C CG2 . THR   A 1 215 ? -11.01253 -23.34907 -14.97336 1.000 18.15238 ? 197  THR   A CG2 1 
ATOM   1413 N N   . TRP   A 1 216 ? -8.46299  -23.41809 -12.69688 1.000 16.88548 ? 198  TRP   A N   1 
ATOM   1414 C CA  . TRP   A 1 216 ? -8.08242  -22.34200 -11.80625 1.000 22.26959 ? 198  TRP   A CA  1 
ATOM   1415 C C   . TRP   A 1 216 ? -8.66516  -21.02898 -12.31735 1.000 24.30672 ? 198  TRP   A C   1 
ATOM   1416 O O   . TRP   A 1 216 ? -9.24807  -20.95049 -13.40413 1.000 22.97093 ? 198  TRP   A O   1 
ATOM   1417 C CB  . TRP   A 1 216 ? -6.56092  -22.24803 -11.68917 1.000 32.78007 ? 198  TRP   A CB  1 
ATOM   1418 C CG  . TRP   A 1 216 ? -5.93430  -21.68024 -12.91164 1.000 23.53667 ? 198  TRP   A CG  1 
ATOM   1419 C CD1 . TRP   A 1 216 ? -5.63440  -20.36309 -13.14449 1.000 30.71072 ? 198  TRP   A CD1 1 
ATOM   1420 C CD2 . TRP   A 1 216 ? -5.53434  -22.39706 -14.08793 1.000 26.69034 ? 198  TRP   A CD2 1 
ATOM   1421 N NE1 . TRP   A 1 216 ? -5.07640  -20.21859 -14.39314 1.000 28.65107 ? 198  TRP   A NE1 1 
ATOM   1422 C CE2 . TRP   A 1 216 ? -5.00480  -21.45297 -14.99195 1.000 34.57668 ? 198  TRP   A CE2 1 
ATOM   1423 C CE3 . TRP   A 1 216 ? -5.57392  -23.74135 -14.46594 1.000 23.46913 ? 198  TRP   A CE3 1 
ATOM   1424 C CZ2 . TRP   A 1 216 ? -4.52015  -21.81611 -16.24873 1.000 27.52710 ? 198  TRP   A CZ2 1 
ATOM   1425 C CZ3 . TRP   A 1 216 ? -5.08692  -24.09629 -15.71884 1.000 17.77196 ? 198  TRP   A CZ3 1 
ATOM   1426 C CH2 . TRP   A 1 216 ? -4.56744  -23.14201 -16.58756 1.000 23.59018 ? 198  TRP   A CH2 1 
ATOM   1427 N N   . HIS   A 1 217 ? -8.52257  -19.98693 -11.51123 1.000 22.52191 ? 199  HIS   A N   1 
ATOM   1428 C CA  . HIS   A 1 217 ? -8.71563  -18.64475 -12.02863 1.000 27.18076 ? 199  HIS   A CA  1 
ATOM   1429 C C   . HIS   A 1 217 ? -7.61567  -17.74364 -11.48487 1.000 30.30367 ? 199  HIS   A C   1 
ATOM   1430 O O   . HIS   A 1 217 ? -7.04700  -18.00813 -10.42264 1.000 47.11552 ? 199  HIS   A O   1 
ATOM   1431 C CB  . HIS   A 1 217 ? -10.08001 -18.06455 -11.66945 1.000 20.86958 ? 199  HIS   A CB  1 
ATOM   1432 C CG  . HIS   A 1 217 ? -10.35996 -16.77443 -12.36675 1.000 25.23660 ? 199  HIS   A CG  1 
ATOM   1433 N ND1 . HIS   A 1 217 ? -10.31299 -15.55317 -11.72989 1.000 39.74367 ? 199  HIS   A ND1 1 
ATOM   1434 C CD2 . HIS   A 1 217 ? -10.67147 -16.51504 -13.66008 1.000 27.99608 ? 199  HIS   A CD2 1 
ATOM   1435 C CE1 . HIS   A 1 217 ? -10.57747 -14.59578 -12.60279 1.000 36.06237 ? 199  HIS   A CE1 1 
ATOM   1436 N NE2 . HIS   A 1 217 ? -10.80637 -15.15348 -13.77999 1.000 24.94913 ? 199  HIS   A NE2 1 
ATOM   1437 N N   . GLY   A 1 218 ? -7.31171  -16.68284 -12.22742 1.000 26.56902 ? 200  GLY   A N   1 
ATOM   1438 C CA  . GLY   A 1 218 ? -6.28066  -15.74484 -11.82445 1.000 26.99159 ? 200  GLY   A CA  1 
ATOM   1439 C C   . GLY   A 1 218 ? -4.90060  -16.23648 -12.19470 1.000 36.54910 ? 200  GLY   A C   1 
ATOM   1440 O O   . GLY   A 1 218 ? -4.77914  -17.27629 -12.84349 1.000 37.96124 ? 200  GLY   A O   1 
ATOM   1441 N N   . GLU   A 1 222 ? -3.68219  -20.73767 -7.72297  1.000 40.34895 ? 204  GLU   A N   1 
ATOM   1442 C CA  . GLU   A 1 222 ? -4.56070  -21.42451 -6.78101  1.000 44.82794 ? 204  GLU   A CA  1 
ATOM   1443 C C   . GLU   A 1 222 ? -5.91165  -21.73876 -7.43372  1.000 60.49751 ? 204  GLU   A C   1 
ATOM   1444 O O   . GLU   A 1 222 ? -6.24913  -21.17692 -8.48122  1.000 56.54429 ? 204  GLU   A O   1 
ATOM   1445 C CB  . GLU   A 1 222 ? -4.74958  -20.58019 -5.52250  1.000 53.88950 ? 204  GLU   A CB  1 
ATOM   1446 C CG  . GLU   A 1 222 ? -4.87277  -19.09587 -5.79607  1.000 54.76172 ? 204  GLU   A CG  1 
ATOM   1447 C CD  . GLU   A 1 222 ? -5.69252  -18.38256 -4.74267  1.000 72.65146 ? 204  GLU   A CD  1 
ATOM   1448 O OE1 . GLU   A 1 222 ? -6.66723  -18.98459 -4.23793  1.000 64.33604 ? 204  GLU   A OE1 1 
ATOM   1449 O OE2 . GLU   A 1 222 ? -5.36001  -17.22122 -4.41945  1.000 74.22157 ? 204  GLU   A OE2 1 
ATOM   1450 N N   . ASP   A 1 223 ? -6.69031  -22.63185 -6.82312  1.000 49.06018 ? 205  ASP   A N   1 
ATOM   1451 C CA  . ASP   A 1 223 ? -7.90380  -23.10181 -7.47537  1.000 49.51324 ? 205  ASP   A CA  1 
ATOM   1452 C C   . ASP   A 1 223 ? -8.94013  -23.54662 -6.45032  1.000 41.95495 ? 205  ASP   A C   1 
ATOM   1453 O O   . ASP   A 1 223 ? -8.61752  -23.91342 -5.31601  1.000 40.64358 ? 205  ASP   A O   1 
ATOM   1454 C CB  . ASP   A 1 223 ? -7.58683  -24.23264 -8.46753  1.000 34.03674 ? 205  ASP   A CB  1 
ATOM   1455 C CG  . ASP   A 1 223 ? -7.15295  -25.52267 -7.77950  1.000 35.79111 ? 205  ASP   A CG  1 
ATOM   1456 O OD1 . ASP   A 1 223 ? -8.00277  -26.22930 -7.19886  1.000 24.05308 ? 205  ASP   A OD1 1 
ATOM   1457 O OD2 . ASP   A 1 223 ? -5.94608  -25.83627 -7.83175  1.000 40.18790 ? 205  ASP   A OD2 1 
ATOM   1458 N N   . ARG   A 1 224 ? -10.20303 -23.49272 -6.88077  1.000 33.34115 ? 206  ARG   A N   1 
ATOM   1459 C CA  . ARG   A 1 224 ? -11.34765 -23.99473 -6.13357  1.000 18.07331 ? 206  ARG   A CA  1 
ATOM   1460 C C   . ARG   A 1 224 ? -11.88799 -25.28282 -6.75303  1.000 21.86538 ? 206  ARG   A C   1 
ATOM   1461 O O   . ARG   A 1 224 ? -13.08802 -25.54918 -6.69087  1.000 19.76303 ? 206  ARG   A O   1 
ATOM   1462 C CB  . ARG   A 1 224 ? -12.45088 -22.93153 -6.07201  1.000 34.08034 ? 206  ARG   A CB  1 
ATOM   1463 C CG  . ARG   A 1 224 ? -11.96847 -21.52637 -5.68231  1.000 39.40389 ? 206  ARG   A CG  1 
ATOM   1464 C CD  . ARG   A 1 224 ? -12.87183 -20.83022 -4.64947  1.000 44.78318 ? 206  ARG   A CD  1 
ATOM   1465 N NE  . ARG   A 1 224 ? -13.80460 -19.86794 -5.23524  1.000 58.44303 ? 206  ARG   A NE  1 
ATOM   1466 C CZ  . ARG   A 1 224 ? -14.66763 -19.13283 -4.53847  1.000 58.04628 ? 206  ARG   A CZ  1 
ATOM   1467 N NH1 . ARG   A 1 224 ? -14.76679 -19.24008 -3.22244  1.000 52.67703 ? 206  ARG   A NH1 1 
ATOM   1468 N NH2 . ARG   A 1 224 ? -15.44556 -18.26085 -5.17698  1.000 41.57784 ? 206  ARG   A NH2 1 
ATOM   1469 N N   . ARG   A 1 225 ? -11.01861 -26.08313 -7.37237  1.000 21.92397 ? 207  ARG   A N   1 
ATOM   1470 C CA  . ARG   A 1 225 ? -11.48312 -27.25879 -8.10216  1.000 19.91852 ? 207  ARG   A CA  1 
ATOM   1471 C C   . ARG   A 1 225 ? -12.23814 -28.20396 -7.17730  1.000 18.52030 ? 207  ARG   A C   1 
ATOM   1472 O O   . ARG   A 1 225 ? -11.85471 -28.40678 -6.02234  1.000 19.03367 ? 207  ARG   A O   1 
ATOM   1473 C CB  . ARG   A 1 225 ? -10.30603 -27.98495 -8.76048  1.000 20.13496 ? 207  ARG   A CB  1 
ATOM   1474 C CG  . ARG   A 1 225 ? -9.80390  -27.28079 -10.01921 1.000 19.13153 ? 207  ARG   A CG  1 
ATOM   1475 C CD  . ARG   A 1 225 ? -8.64569  -28.00985 -10.68739 1.000 16.91536 ? 207  ARG   A CD  1 
ATOM   1476 N NE  . ARG   A 1 225 ? -9.05672  -29.25885 -11.31924 1.000 21.87877 ? 207  ARG   A NE  1 
ATOM   1477 C CZ  . ARG   A 1 225 ? -8.91292  -30.46479 -10.78546 1.000 22.96432 ? 207  ARG   A CZ  1 
ATOM   1478 N NH1 . ARG   A 1 225 ? -8.33902  -30.63693 -9.60319  1.000 23.51138 ? 207  ARG   A NH1 1 
ATOM   1479 N NH2 . ARG   A 1 225 ? -9.35340  -31.52618 -11.45658 1.000 20.92186 ? 207  ARG   A NH2 1 
ATOM   1480 N N   . GLY   A 1 226 ? -13.33572 -28.76253 -7.69059  1.000 14.42856 ? 208  GLY   A N   1 
ATOM   1481 C CA  . GLY   A 1 226 ? -14.21906 -29.61396 -6.91959  1.000 20.22100 ? 208  GLY   A CA  1 
ATOM   1482 C C   . GLY   A 1 226 ? -15.32690 -28.88680 -6.17848  1.000 21.97246 ? 208  GLY   A C   1 
ATOM   1483 O O   . GLY   A 1 226 ? -16.34752 -29.50547 -5.84550  1.000 21.50009 ? 208  GLY   A O   1 
ATOM   1484 N N   . GLN   A 1 227 ? -15.15495 -27.60187 -5.89600  1.000 18.02939 ? 209  GLN   A N   1 
ATOM   1485 C CA  . GLN   A 1 227 ? -16.18378 -26.83843 -5.20858  1.000 18.73598 ? 209  GLN   A CA  1 
ATOM   1486 C C   . GLN   A 1 227 ? -17.33133 -26.49991 -6.15928  1.000 14.23701 ? 209  GLN   A C   1 
ATOM   1487 O O   . GLN   A 1 227 ? -17.18968 -26.53391 -7.38487  1.000 16.53384 ? 209  GLN   A O   1 
ATOM   1488 C CB  . GLN   A 1 227 ? -15.60168 -25.54394 -4.63235  1.000 18.01161 ? 209  GLN   A CB  1 
ATOM   1489 C CG  . GLN   A 1 227 ? -14.39667 -25.72012 -3.71844  1.000 23.20277 ? 209  GLN   A CG  1 
ATOM   1490 C CD  . GLN   A 1 227 ? -13.83736 -24.39000 -3.25265  1.000 28.52631 ? 209  GLN   A CD  1 
ATOM   1491 O OE1 . GLN   A 1 227 ? -14.51245 -23.36479 -3.32571  1.000 33.56166 ? 209  GLN   A OE1 1 
ATOM   1492 N NE2 . GLN   A 1 227 ? -12.59882 -24.39742 -2.77933  1.000 26.22472 ? 209  GLN   A NE2 1 
ATOM   1493 N N   . THR   A 1 228 ? -18.48755 -26.18285 -5.57495  1.000 14.80592 ? 210  THR   A N   1 
ATOM   1494 C CA  . THR   A 1 228 ? -19.56002 -25.54882 -6.33118  1.000 15.41333 ? 210  THR   A CA  1 
ATOM   1495 C C   . THR   A 1 228 ? -19.24765 -24.06104 -6.51586  1.000 12.36983 ? 210  THR   A C   1 
ATOM   1496 O O   . THR   A 1 228 ? -18.32917 -23.51190 -5.89237  1.000 14.23775 ? 210  THR   A O   1 
ATOM   1497 C CB  . THR   A 1 228 ? -20.90728 -25.70241 -5.61980  1.000 27.61464 ? 210  THR   A CB  1 
ATOM   1498 O OG1 . THR   A 1 228 ? -20.93101 -24.86705 -4.44987  1.000 21.37731 ? 210  THR   A OG1 1 
ATOM   1499 C CG2 . THR   A 1 228 ? -21.15860 -27.16878 -5.22265  1.000 17.94271 ? 210  THR   A CG2 1 
ATOM   1500 N N   . VAL   A 1 229 ? -20.04129 -23.39256 -7.36196  1.000 15.59706 ? 211  VAL   A N   1 
ATOM   1501 C CA  . VAL   A 1 229 ? -19.88747 -21.94791 -7.54214  1.000 18.44228 ? 211  VAL   A CA  1 
ATOM   1502 C C   . VAL   A 1 229 ? -20.84269 -21.18212 -6.62808  1.000 22.50599 ? 211  VAL   A C   1 
ATOM   1503 O O   . VAL   A 1 229 ? -20.93873 -19.95570 -6.71964  1.000 18.17952 ? 211  VAL   A O   1 
ATOM   1504 C CB  . VAL   A 1 229 ? -20.09084 -21.52428 -9.01440  1.000 16.10126 ? 211  VAL   A CB  1 
ATOM   1505 C CG1 . VAL   A 1 229 ? -19.07926 -22.22610 -9.92682  1.000 15.15122 ? 211  VAL   A CG1 1 
ATOM   1506 C CG2 . VAL   A 1 229 ? -21.52159 -21.80747 -9.47835  1.000 14.21233 ? 211  VAL   A CG2 1 
ATOM   1507 N N   . ASN   A 1 230 ? -21.53754 -21.88882 -5.72619  1.000 20.71764 ? 212  ASN   A N   1 
ATOM   1508 C CA  . ASN   A 1 230 ? -22.53949 -21.24447 -4.87094  1.000 19.66368 ? 212  ASN   A CA  1 
ATOM   1509 C C   . ASN   A 1 230 ? -21.96882 -20.03479 -4.13230  1.000 20.18253 ? 212  ASN   A C   1 
ATOM   1510 O O   . ASN   A 1 230 ? -22.58197 -18.95953 -4.10306  1.000 17.04414 ? 212  ASN   A O   1 
ATOM   1511 C CB  . ASN   A 1 230 ? -23.10542 -22.25839 -3.87093  1.000 21.83130 ? 212  ASN   A CB  1 
ATOM   1512 C CG  . ASN   A 1 230 ? -23.99951 -23.28927 -4.52491  1.000 24.19589 ? 212  ASN   A CG  1 
ATOM   1513 O OD1 . ASN   A 1 230 ? -23.95962 -23.48533 -5.73769  1.000 26.76098 ? 212  ASN   A OD1 1 
ATOM   1514 N ND2 . ASN   A 1 230 ? -24.80836 -23.96963 -3.71891  1.000 34.97577 ? 212  ASN   A ND2 1 
ATOM   1515 N N   . ALA   A 1 231 ? -20.79010 -20.19102 -3.52558  1.000 17.99068 ? 213  ALA   A N   1 
ATOM   1516 C CA  . ALA   A 1 231 ? -20.22460 -19.09530 -2.74582  1.000 23.08299 ? 213  ALA   A CA  1 
ATOM   1517 C C   . ALA   A 1 231 ? -19.83213 -17.91612 -3.62994  1.000 24.04332 ? 213  ALA   A C   1 
ATOM   1518 O O   . ALA   A 1 231 ? -19.96012 -16.76239 -3.20822  1.000 20.62592 ? 213  ALA   A O   1 
ATOM   1519 C CB  . ALA   A 1 231 ? -19.02433 -19.57892 -1.94327  1.000 18.13600 ? 213  ALA   A CB  1 
ATOM   1520 N N   . GLY   A 1 232 ? -19.36229 -18.17964 -4.85105  1.000 19.48559 ? 214  GLY   A N   1 
ATOM   1521 C CA  . GLY   A 1 232 ? -19.05372 -17.08587 -5.75714  1.000 20.69017 ? 214  GLY   A CA  1 
ATOM   1522 C C   . GLY   A 1 232 ? -20.29530 -16.33812 -6.20841  1.000 21.24795 ? 214  GLY   A C   1 
ATOM   1523 O O   . GLY   A 1 232 ? -20.30317 -15.10574 -6.25911  1.000 16.11383 ? 214  GLY   A O   1 
ATOM   1524 N N   . VAL   A 1 233 ? -21.36250 -17.06920 -6.53884  1.000 17.15385 ? 215  VAL   A N   1 
ATOM   1525 C CA  . VAL   A 1 233 ? -22.63502 -16.42322 -6.85584  1.000 16.91405 ? 215  VAL   A CA  1 
ATOM   1526 C C   . VAL   A 1 233 ? -23.11607 -15.58981 -5.67180  1.000 23.55727 ? 215  VAL   A C   1 
ATOM   1527 O O   . VAL   A 1 233 ? -23.63862 -14.47778 -5.84229  1.000 22.42850 ? 215  VAL   A O   1 
ATOM   1528 C CB  . VAL   A 1 233 ? -23.68120 -17.47786 -7.27355  1.000 21.33561 ? 215  VAL   A CB  1 
ATOM   1529 C CG1 . VAL   A 1 233 ? -25.09452 -16.87921 -7.29721  1.000 18.69190 ? 215  VAL   A CG1 1 
ATOM   1530 C CG2 . VAL   A 1 233 ? -23.32862 -18.09079 -8.64152  1.000 16.75177 ? 215  VAL   A CG2 1 
ATOM   1531 N N   . ALA   A 1 234 ? -22.91298 -16.09687 -4.45186  1.000 18.22938 ? 216  ALA   A N   1 
ATOM   1532 C CA  . ALA   A 1 234 ? -23.42908 -15.42740 -3.25981  1.000 22.12446 ? 216  ALA   A CA  1 
ATOM   1533 C C   . ALA   A 1 234 ? -22.65330 -14.16155 -2.92996  1.000 21.03619 ? 216  ALA   A C   1 
ATOM   1534 O O   . ALA   A 1 234 ? -23.23971 -13.19857 -2.41644  1.000 24.24816 ? 216  ALA   A O   1 
ATOM   1535 C CB  . ALA   A 1 234 ? -23.40760 -16.38203 -2.06160  1.000 21.96308 ? 216  ALA   A CB  1 
ATOM   1536 N N   . GLU   A 1 235 ? -21.35199 -14.12476 -3.22016  1.000 17.38418 ? 217  GLU   A N   1 
ATOM   1537 C CA  . GLU   A 1 235 ? -20.56186 -12.95274 -2.86690  1.000 21.22414 ? 217  GLU   A CA  1 
ATOM   1538 C C   . GLU   A 1 235 ? -20.77936 -11.77688 -3.81521  1.000 18.60039 ? 217  GLU   A C   1 
ATOM   1539 O O   . GLU   A 1 235 ? -20.19557 -10.71232 -3.58480  1.000 20.56672 ? 217  GLU   A O   1 
ATOM   1540 C CB  . GLU   A 1 235 ? -19.06741 -13.30717 -2.81231  1.000 22.97538 ? 217  GLU   A CB  1 
ATOM   1541 C CG  . GLU   A 1 235 ? -18.47960 -13.73113 -4.14824  1.000 27.36290 ? 217  GLU   A CG  1 
ATOM   1542 C CD  . GLU   A 1 235 ? -17.02115 -14.15965 -4.06244  1.000 33.92062 ? 217  GLU   A CD  1 
ATOM   1543 O OE1 . GLU   A 1 235 ? -16.44609 -14.11356 -2.95211  1.000 34.39695 ? 217  GLU   A OE1 1 
ATOM   1544 O OE2 . GLU   A 1 235 ? -16.46002 -14.54529 -5.11622  1.000 28.99848 ? 217  GLU   A OE2 1 
ATOM   1545 N N   . ARG   A 1 236 ? -21.58343 -11.94954 -4.86928  1.000 15.24937 ? 218  ARG   A N   1 
ATOM   1546 C CA  . ARG   A 1 236 ? -21.93525 -10.87672 -5.80601  1.000 21.30641 ? 218  ARG   A CA  1 
ATOM   1547 C C   . ARG   A 1 236 ? -20.70782 -10.32787 -6.53611  1.000 20.51871 ? 218  ARG   A C   1 
ATOM   1548 O O   . ARG   A 1 236 ? -20.62917 -9.13450  -6.85911  1.000 16.98257 ? 218  ARG   A O   1 
ATOM   1549 C CB  . ARG   A 1 236 ? -22.69243 -9.74826  -5.09838  1.000 21.55949 ? 218  ARG   A CB  1 
ATOM   1550 C CG  . ARG   A 1 236 ? -24.04546 -10.14181 -4.54729  1.000 24.24586 ? 218  ARG   A CG  1 
ATOM   1551 C CD  . ARG   A 1 236 ? -24.93825 -8.90571  -4.40880  1.000 38.49016 ? 218  ARG   A CD  1 
ATOM   1552 N NE  . ARG   A 1 236 ? -26.28245 -9.14583  -4.92221  1.000 50.25996 ? 218  ARG   A NE  1 
ATOM   1553 C CZ  . ARG   A 1 236 ? -26.99137 -8.26430  -5.61379  1.000 40.96324 ? 218  ARG   A CZ  1 
ATOM   1554 N NH1 . ARG   A 1 236 ? -26.50885 -7.06591  -5.90555  1.000 43.52296 ? 218  ARG   A NH1 1 
ATOM   1555 N NH2 . ARG   A 1 236 ? -28.21119 -8.59704  -6.03173  1.000 35.87141 ? 218  ARG   A NH2 1 
ATOM   1556 N N   . SER   A 1 237 ? -19.73425 -11.19494 -6.78847  1.000 16.77472 ? 219  SER   A N   1 
ATOM   1557 C CA  . SER   A 1 237 ? -18.58610 -10.83904 -7.59379  1.000 17.17368 ? 219  SER   A CA  1 
ATOM   1558 C C   . SER   A 1 237 ? -18.94591 -10.86135 -9.07424  1.000 18.86308 ? 219  SER   A C   1 
ATOM   1559 O O   . SER   A 1 237 ? -19.79293 -11.64014 -9.52157  1.000 12.55966 ? 219  SER   A O   1 
ATOM   1560 C CB  . SER   A 1 237 ? -17.45289 -11.81962 -7.33923  1.000 15.20636 ? 219  SER   A CB  1 
ATOM   1561 O OG  . SER   A 1 237 ? -17.89744 -13.10929 -7.68408  1.000 16.02008 ? 219  SER   A OG  1 
ATOM   1562 N N   . TRP   A 1 238 ? -18.28069 -10.00057 -9.84240  1.000 16.30073 ? 220  TRP   A N   1 
ATOM   1563 C CA  . TRP   A 1 238 ? -18.47344 -10.03034 -11.28787 1.000 14.69023 ? 220  TRP   A CA  1 
ATOM   1564 C C   . TRP   A 1 238 ? -18.07178 -11.38514 -11.86724 1.000 11.11564 ? 220  TRP   A C   1 
ATOM   1565 O O   . TRP   A 1 238 ? -18.64738 -11.83589 -12.86577 1.000 12.94841 ? 220  TRP   A O   1 
ATOM   1566 C CB  . TRP   A 1 238 ? -17.67402 -8.89862  -11.93525 1.000 11.85921 ? 220  TRP   A CB  1 
ATOM   1567 C CG  . TRP   A 1 238 ? -17.55781 -9.00051  -13.43011 1.000 12.73529 ? 220  TRP   A CG  1 
ATOM   1568 C CD1 . TRP   A 1 238 ? -18.53304 -8.74817  -14.34272 1.000 13.47166 ? 220  TRP   A CD1 1 
ATOM   1569 C CD2 . TRP   A 1 238 ? -16.39497 -9.36736  -14.17444 1.000 9.15697  ? 220  TRP   A CD2 1 
ATOM   1570 N NE1 . TRP   A 1 238 ? -18.05421 -8.93569  -15.61426 1.000 12.76687 ? 220  TRP   A NE1 1 
ATOM   1571 C CE2 . TRP   A 1 238 ? -16.74261 -9.32107  -15.53918 1.000 11.58209 ? 220  TRP   A CE2 1 
ATOM   1572 C CE3 . TRP   A 1 238 ? -15.09468 -9.74041  -13.82042 1.000 13.48017 ? 220  TRP   A CE3 1 
ATOM   1573 C CZ2 . TRP   A 1 238 ? -15.83776 -9.62804  -16.55253 1.000 12.09368 ? 220  TRP   A CZ2 1 
ATOM   1574 C CZ3 . TRP   A 1 238 ? -14.19371 -10.04611 -14.82968 1.000 15.01778 ? 220  TRP   A CZ3 1 
ATOM   1575 C CH2 . TRP   A 1 238 ? -14.57139 -9.99079  -16.17669 1.000 14.82688 ? 220  TRP   A CH2 1 
ATOM   1576 N N   . LEU   A 1 239 ? -17.12580 -12.06938 -11.22820 1.000 14.49164 ? 221  LEU   A N   1 
ATOM   1577 C CA  . LEU   A 1 239 ? -16.62873 -13.32079 -11.79193 1.000 16.49784 ? 221  LEU   A CA  1 
ATOM   1578 C C   . LEU   A 1 239 ? -17.72391 -14.37458 -11.93822 1.000 10.92459 ? 221  LEU   A C   1 
ATOM   1579 O O   . LEU   A 1 239 ? -17.63598 -15.22532 -12.83056 1.000 14.47174 ? 221  LEU   A O   1 
ATOM   1580 C CB  . LEU   A 1 239 ? -15.46718 -13.85940 -10.94817 1.000 14.85945 ? 221  LEU   A CB  1 
ATOM   1581 C CG  . LEU   A 1 239 ? -14.59686 -14.79919 -11.77662 1.000 14.52289 ? 221  LEU   A CG  1 
ATOM   1582 C CD1 . LEU   A 1 239 ? -13.77633 -13.96854 -12.75881 1.000 17.76606 ? 221  LEU   A CD1 1 
ATOM   1583 C CD2 . LEU   A 1 239 ? -13.69216 -15.63596 -10.87459 1.000 17.53427 ? 221  LEU   A CD2 1 
ATOM   1584 N N   . TYR   A 1 240 ? -18.75932 -14.35342 -11.09349 1.000 15.01458 ? 222  TYR   A N   1 
ATOM   1585 C CA  . TYR   A 1 240 ? -19.84919 -15.32223 -11.22699 1.000 12.30658 ? 222  TYR   A CA  1 
ATOM   1586 C C   . TYR   A 1 240 ? -21.16423 -14.68023 -11.65596 1.000 13.66095 ? 222  TYR   A C   1 
ATOM   1587 O O   . TYR   A 1 240 ? -22.17525 -15.38334 -11.76851 1.000 14.34015 ? 222  TYR   A O   1 
ATOM   1588 C CB  . TYR   A 1 240 ? -20.02215 -16.11646 -9.91605  1.000 11.51749 ? 222  TYR   A CB  1 
ATOM   1589 C CG  . TYR   A 1 240 ? -18.77190 -16.92959 -9.63101  1.000 9.90766  ? 222  TYR   A CG  1 
ATOM   1590 C CD1 . TYR   A 1 240 ? -18.61121 -18.20928 -10.15886 1.000 13.72193 ? 222  TYR   A CD1 1 
ATOM   1591 C CD2 . TYR   A 1 240 ? -17.71201 -16.38071 -8.90493  1.000 16.06672 ? 222  TYR   A CD2 1 
ATOM   1592 C CE1 . TYR   A 1 240 ? -17.44278 -18.94158 -9.93181  1.000 14.73464 ? 222  TYR   A CE1 1 
ATOM   1593 C CE2 . TYR   A 1 240 ? -16.54308 -17.10455 -8.67270  1.000 15.14686 ? 222  TYR   A CE2 1 
ATOM   1594 C CZ  . TYR   A 1 240 ? -16.41521 -18.38000 -9.18970  1.000 21.20076 ? 222  TYR   A CZ  1 
ATOM   1595 O OH  . TYR   A 1 240 ? -15.24593 -19.09079 -8.96835  1.000 18.48384 ? 222  TYR   A OH  1 
ATOM   1596 N N   . LEU   A 1 241 ? -21.16262 -13.36926 -11.90898 1.000 11.58497 ? 223  LEU   A N   1 
ATOM   1597 C CA  . LEU   A 1 241 ? -22.27189 -12.63700 -12.52640 1.000 8.96193  ? 223  LEU   A CA  1 
ATOM   1598 C C   . LEU   A 1 241 ? -23.56219 -12.73779 -11.71680 1.000 10.99084 ? 223  LEU   A C   1 
ATOM   1599 O O   . LEU   A 1 241 ? -24.65310 -12.66437 -12.27962 1.000 12.19601 ? 223  LEU   A O   1 
ATOM   1600 C CB  . LEU   A 1 241 ? -22.50880 -13.10847 -13.96774 1.000 13.85579 ? 223  LEU   A CB  1 
ATOM   1601 C CG  . LEU   A 1 241 ? -21.32533 -12.91698 -14.92718 1.000 15.96605 ? 223  LEU   A CG  1 
ATOM   1602 C CD1 . LEU   A 1 241 ? -21.62324 -13.60090 -16.25851 1.000 11.67409 ? 223  LEU   A CD1 1 
ATOM   1603 C CD2 . LEU   A 1 241 ? -21.02314 -11.40481 -15.12310 1.000 11.78561 ? 223  LEU   A CD2 1 
ATOM   1604 N N   . LYS   A 1 242 ? -23.45052 -12.93522 -10.40134 1.000 14.04863 ? 224  LYS   A N   1 
ATOM   1605 C CA  . LYS   A 1 242 ? -24.61174 -13.11921 -9.52663  1.000 13.33985 ? 224  LYS   A CA  1 
ATOM   1606 C C   . LYS   A 1 242 ? -25.50232 -14.26802 -9.99936  1.000 18.93197 ? 224  LYS   A C   1 
ATOM   1607 O O   . LYS   A 1 242 ? -26.71146 -14.26197 -9.76180  1.000 18.19492 ? 224  LYS   A O   1 
ATOM   1608 C CB  . LYS   A 1 242 ? -25.42902 -11.82085 -9.41169  1.000 17.85690 ? 224  LYS   A CB  1 
ATOM   1609 C CG  . LYS   A 1 242 ? -24.67686 -10.66191 -8.75866  1.000 19.37097 ? 224  LYS   A CG  1 
ATOM   1610 C CD  . LYS   A 1 242 ? -25.55405 -9.41702  -8.64542  1.000 28.22731 ? 224  LYS   A CD  1 
ATOM   1611 C CE  . LYS   A 1 242 ? -25.10154 -8.32736  -9.61748  1.000 26.41502 ? 224  LYS   A CE  1 
ATOM   1612 N NZ  . LYS   A 1 242 ? -26.12972 -7.25980  -9.82909  1.000 26.69980 ? 224  LYS   A NZ  1 
ATOM   1613 N N   . GLY   A 1 243 ? -24.92115 -15.27161 -10.67721 1.000 14.66268 ? 225  GLY   A N   1 
ATOM   1614 C CA  . GLY   A 1 243 ? -25.69525 -16.36489 -11.22545 1.000 10.60488 ? 225  GLY   A CA  1 
ATOM   1615 C C   . GLY   A 1 243 ? -26.20179 -16.17279 -12.64461 1.000 15.31346 ? 225  GLY   A C   1 
ATOM   1616 O O   . GLY   A 1 243 ? -26.74880 -17.12576 -13.22475 1.000 15.99548 ? 225  GLY   A O   1 
ATOM   1617 N N   . SER   A 1 244 ? -26.03801 -14.98851 -13.23050 1.000 13.70553 ? 226  SER   A N   1 
ATOM   1618 C CA  . SER   A 1 244 ? -26.50929 -14.74121 -14.59573 1.000 11.76674 ? 226  SER   A CA  1 
ATOM   1619 C C   . SER   A 1 244 ? -25.43687 -15.07355 -15.62652 1.000 16.00253 ? 226  SER   A C   1 
ATOM   1620 O O   . SER   A 1 244 ? -25.11643 -14.27639 -16.51110 1.000 12.54015 ? 226  SER   A O   1 
ATOM   1621 C CB  . SER   A 1 244 ? -26.97290 -13.29374 -14.74112 1.000 15.80858 ? 226  SER   A CB  1 
ATOM   1622 O OG  . SER   A 1 244 ? -27.93201 -12.99330 -13.74860 1.000 16.61248 ? 226  SER   A OG  1 
ATOM   1623 N N   . TYR   A 1 245 ? -24.88606 -16.27578 -15.51966 1.000 14.80087 ? 227  TYR   A N   1 
ATOM   1624 C CA  . TYR   A 1 245 ? -23.83287 -16.74381 -16.40382 1.000 14.43545 ? 227  TYR   A CA  1 
ATOM   1625 C C   . TYR   A 1 245 ? -24.40575 -17.66849 -17.47200 1.000 17.73245 ? 227  TYR   A C   1 
ATOM   1626 O O   . TYR   A 1 245 ? -25.53624 -18.15723 -17.37198 1.000 14.58038 ? 227  TYR   A O   1 
ATOM   1627 C CB  . TYR   A 1 245 ? -22.74057 -17.45417 -15.59395 1.000 13.98557 ? 227  TYR   A CB  1 
ATOM   1628 C CG  . TYR   A 1 245 ? -23.21363 -18.64535 -14.77794 1.000 16.37073 ? 227  TYR   A CG  1 
ATOM   1629 C CD1 . TYR   A 1 245 ? -23.31834 -19.90748 -15.35281 1.000 16.13413 ? 227  TYR   A CD1 1 
ATOM   1630 C CD2 . TYR   A 1 245 ? -23.52323 -18.51434 -13.42608 1.000 15.12244 ? 227  TYR   A CD2 1 
ATOM   1631 C CE1 . TYR   A 1 245 ? -23.73025 -21.00171 -14.61516 1.000 16.28499 ? 227  TYR   A CE1 1 
ATOM   1632 C CE2 . TYR   A 1 245 ? -23.93282 -19.60908 -12.67523 1.000 20.10000 ? 227  TYR   A CE2 1 
ATOM   1633 C CZ  . TYR   A 1 245 ? -24.03149 -20.85050 -13.27992 1.000 17.10317 ? 227  TYR   A CZ  1 
ATOM   1634 O OH  . TYR   A 1 245 ? -24.43394 -21.94915 -12.55700 1.000 21.84167 ? 227  TYR   A OH  1 
ATOM   1635 N N   A MET   A 1 246 ? -23.58989 -17.93551 -18.49183 0.652 13.28507 ? 228  MET   A N   1 
ATOM   1636 N N   B MET   A 1 246 ? -23.60657 -17.89825 -18.50895 0.348 13.36080 ? 228  MET   A N   1 
ATOM   1637 C CA  A MET   A 1 246 ? -24.02112 -18.69938 -19.65935 0.652 13.14036 ? 228  MET   A CA  1 
ATOM   1638 C CA  B MET   A 1 246 ? -24.05184 -18.70224 -19.63655 0.348 13.23414 ? 228  MET   A CA  1 
ATOM   1639 C C   A MET   A 1 246 ? -23.94320 -20.20117 -19.39530 0.652 17.72720 ? 228  MET   A C   1 
ATOM   1640 C C   B MET   A 1 246 ? -23.97551 -20.18702 -19.30665 0.348 17.67074 ? 228  MET   A C   1 
ATOM   1641 O O   A MET   A 1 246 ? -22.87383 -20.72320 -19.06740 0.652 17.13397 ? 228  MET   A O   1 
ATOM   1642 O O   B MET   A 1 246 ? -22.95612 -20.67342 -18.80897 0.348 17.07004 ? 228  MET   A O   1 
ATOM   1643 C CB  A MET   A 1 246 ? -23.15491 -18.34242 -20.86388 0.652 14.85354 ? 228  MET   A CB  1 
ATOM   1644 C CB  B MET   A 1 246 ? -23.21920 -18.39263 -20.88028 0.348 14.90746 ? 228  MET   A CB  1 
ATOM   1645 C CG  A MET   A 1 246 ? -23.11198 -16.87079 -21.22722 0.652 16.12955 ? 228  MET   A CG  1 
ATOM   1646 C CG  B MET   A 1 246 ? -23.91849 -18.79778 -22.16582 0.348 14.84003 ? 228  MET   A CG  1 
ATOM   1647 S SD  A MET   A 1 246 ? -21.89884 -16.62827 -22.54137 0.652 24.38450 ? 228  MET   A SD  1 
ATOM   1648 S SD  B MET   A 1 246 ? -23.27737 -18.11148 -23.70973 0.348 21.66861 ? 228  MET   A SD  1 
ATOM   1649 C CE  A MET   A 1 246 ? -22.30911 -17.98179 -23.65157 0.652 27.28106 ? 228  MET   A CE  1 
ATOM   1650 C CE  B MET   A 1 246 ? -22.26092 -16.78000 -23.07144 0.348 20.88302 ? 228  MET   A CE  1 
ATOM   1651 N N   . ARG   A 1 247 ? -25.06363 -20.89734 -19.57491 1.000 10.54817 ? 229  ARG   A N   1 
ATOM   1652 C CA  . ARG   A 1 247 ? -25.11801 -22.35568 -19.49541 1.000 21.22173 ? 229  ARG   A CA  1 
ATOM   1653 C C   . ARG   A 1 247 ? -25.22557 -22.84710 -20.93222 1.000 20.19320 ? 229  ARG   A C   1 
ATOM   1654 O O   . ARG   A 1 247 ? -26.30367 -22.80608 -21.52897 1.000 17.97565 ? 229  ARG   A O   1 
ATOM   1655 C CB  . ARG   A 1 247 ? -26.30373 -22.83223 -18.65988 1.000 24.62176 ? 229  ARG   A CB  1 
ATOM   1656 C CG  . ARG   A 1 247 ? -26.09976 -22.75475 -17.15876 1.000 21.87809 ? 229  ARG   A CG  1 
ATOM   1657 C CD  . ARG   A 1 247 ? -26.76200 -21.50133 -16.62021 1.000 25.44779 ? 229  ARG   A CD  1 
ATOM   1658 N NE  . ARG   A 1 247 ? -27.08854 -21.59418 -15.20340 1.000 27.18035 ? 229  ARG   A NE  1 
ATOM   1659 C CZ  . ARG   A 1 247 ? -27.23759 -20.54004 -14.41318 1.000 34.41012 ? 229  ARG   A CZ  1 
ATOM   1660 N NH1 . ARG   A 1 247 ? -27.09125 -19.30520 -14.87412 1.000 24.99132 ? 229  ARG   A NH1 1 
ATOM   1661 N NH2 . ARG   A 1 247 ? -27.53428 -20.72671 -13.12967 1.000 36.18228 ? 229  ARG   A NH2 1 
ATOM   1662 N N   . CYS   A 1 248 ? -24.10712 -23.30257 -21.48811 1.000 16.03331 ? 230  CYS   A N   1 
ATOM   1663 C CA  . CYS   A 1 248 ? -24.06401 -23.67407 -22.89327 1.000 16.63670 ? 230  CYS   A CA  1 
ATOM   1664 C C   . CYS   A 1 248 ? -24.79714 -24.98480 -23.14670 1.000 20.25359 ? 230  CYS   A C   1 
ATOM   1665 O O   . CYS   A 1 248 ? -24.79766 -25.89206 -22.31153 1.000 17.50669 ? 230  CYS   A O   1 
ATOM   1666 C CB  . CYS   A 1 248 ? -22.61727 -23.83796 -23.36485 1.000 17.33416 ? 230  CYS   A CB  1 
ATOM   1667 S SG  . CYS   A 1 248 ? -21.63523 -22.35719 -23.32267 1.000 18.26008 ? 230  CYS   A SG  1 
ATOM   1668 N N   . ASP   A 1 249 ? -25.41294 -25.07864 -24.32389 1.000 17.66040 ? 231  ASP   A N   1 
ATOM   1669 C CA  . ASP   A 1 249 ? -25.67505 -26.37843 -24.92048 1.000 25.36233 ? 231  ASP   A CA  1 
ATOM   1670 C C   . ASP   A 1 249 ? -24.50886 -26.73196 -25.84683 1.000 19.50875 ? 231  ASP   A C   1 
ATOM   1671 O O   . ASP   A 1 249 ? -23.52665 -25.99316 -25.95141 1.000 19.05065 ? 231  ASP   A O   1 
ATOM   1672 C CB  . ASP   A 1 249 ? -27.02968 -26.39767 -25.63733 1.000 27.00749 ? 231  ASP   A CB  1 
ATOM   1673 C CG  . ASP   A 1 249 ? -27.15398 -25.34192 -26.73055 1.000 32.28501 ? 231  ASP   A CG  1 
ATOM   1674 O OD1 . ASP   A 1 249 ? -26.13364 -24.79423 -27.20868 1.000 21.34788 ? 231  ASP   A OD1 1 
ATOM   1675 O OD2 . ASP   A 1 249 ? -28.30604 -25.06117 -27.12588 1.000 31.10559 ? 231  ASP   A OD2 1 
ATOM   1676 N N   . ARG   A 1 250 ? -24.60339 -27.87517 -26.52991 1.000 23.60172 ? 232  ARG   A N   1 
ATOM   1677 C CA  . ARG   A 1 250 ? -23.49227 -28.30147 -27.37402 1.000 21.31874 ? 232  ARG   A CA  1 
ATOM   1678 C C   . ARG   A 1 250 ? -23.21822 -27.30150 -28.48463 1.000 18.32891 ? 232  ARG   A C   1 
ATOM   1679 O O   . ARG   A 1 250 ? -22.06330 -27.11897 -28.88584 1.000 19.15420 ? 232  ARG   A O   1 
ATOM   1680 C CB  . ARG   A 1 250 ? -23.77452 -29.67805 -27.97313 1.000 26.75830 ? 232  ARG   A CB  1 
ATOM   1681 C CG  . ARG   A 1 250 ? -23.67079 -30.81654 -26.97675 1.000 39.87291 ? 232  ARG   A CG  1 
ATOM   1682 C CD  . ARG   A 1 250 ? -22.23723 -31.23203 -26.69316 1.000 23.31830 ? 232  ARG   A CD  1 
ATOM   1683 N NE  . ARG   A 1 250 ? -22.21583 -32.28707 -25.68863 1.000 23.83499 ? 232  ARG   A NE  1 
ATOM   1684 C CZ  . ARG   A 1 250 ? -21.90835 -32.10374 -24.41325 1.000 32.47824 ? 232  ARG   A CZ  1 
ATOM   1685 N NH1 . ARG   A 1 250 ? -21.52159 -30.92412 -23.95977 1.000 27.19038 ? 232  ARG   A NH1 1 
ATOM   1686 N NH2 . ARG   A 1 250 ? -21.98679 -33.13160 -23.57203 1.000 27.48102 ? 232  ARG   A NH2 1 
ATOM   1687 N N   . LYS   A 1 251 ? -24.25672 -26.64000 -28.98891 1.000 13.98835 ? 233  LYS   A N   1 
ATOM   1688 C CA  . LYS   A 1 251 ? -24.05605 -25.67229 -30.06406 1.000 20.82602 ? 233  LYS   A CA  1 
ATOM   1689 C C   . LYS   A 1 251 ? -23.34891 -24.41780 -29.56921 1.000 16.37553 ? 233  LYS   A C   1 
ATOM   1690 O O   . LYS   A 1 251 ? -22.54434 -23.82526 -30.30254 1.000 16.82453 ? 233  LYS   A O   1 
ATOM   1691 C CB  . LYS   A 1 251 ? -25.39302 -25.31228 -30.69981 1.000 24.25361 ? 233  LYS   A CB  1 
ATOM   1692 C CG  . LYS   A 1 251 ? -26.27509 -26.50550 -30.95186 1.000 32.84917 ? 233  LYS   A CG  1 
ATOM   1693 C CD  . LYS   A 1 251 ? -25.76253 -27.27253 -32.14622 1.000 23.10597 ? 233  LYS   A CD  1 
ATOM   1694 C CE  . LYS   A 1 251 ? -26.91234 -27.81279 -32.97037 1.000 37.72889 ? 233  LYS   A CE  1 
ATOM   1695 N NZ  . LYS   A 1 251 ? -27.67805 -28.83127 -32.21136 1.000 44.04733 ? 233  LYS   A NZ  1 
ATOM   1696 N N   . MET   A 1 252 ? -23.64314 -23.97412 -28.34418 1.000 21.37609 ? 234  MET   A N   1 
ATOM   1697 C CA  . MET   A 1 252 ? -22.87470 -22.83986 -27.85345 1.000 14.74320 ? 234  MET   A CA  1 
ATOM   1698 C C   . MET   A 1 252 ? -21.45107 -23.23481 -27.49063 1.000 13.70002 ? 234  MET   A C   1 
ATOM   1699 O O   . MET   A 1 252 ? -20.56547 -22.37280 -27.50516 1.000 15.29603 ? 234  MET   A O   1 
ATOM   1700 C CB  . MET   A 1 252 ? -23.51416 -22.13313 -26.64584 1.000 16.27353 ? 234  MET   A CB  1 
ATOM   1701 C CG  . MET   A 1 252 ? -24.83159 -21.41607 -26.91800 1.000 20.68612 ? 234  MET   A CG  1 
ATOM   1702 S SD  . MET   A 1 252 ? -26.14408 -21.72903 -25.71398 1.000 25.81376 ? 234  MET   A SD  1 
ATOM   1703 C CE  . MET   A 1 252 ? -25.53043 -20.73422 -24.39384 1.000 18.31826 ? 234  MET   A CE  1 
ATOM   1704 N N   . GLU   A 1 253 ? -21.20650 -24.51015 -27.17279 1.000 14.46728 ? 235  GLU   A N   1 
ATOM   1705 C CA  . GLU   A 1 253 ? -19.82951 -24.95508 -26.96541 1.000 14.98884 ? 235  GLU   A CA  1 
ATOM   1706 C C   . GLU   A 1 253 ? -19.02680 -24.89636 -28.26105 1.000 20.37666 ? 235  GLU   A C   1 
ATOM   1707 O O   . GLU   A 1 253 ? -17.82006 -24.62398 -28.23037 1.000 15.57228 ? 235  GLU   A O   1 
ATOM   1708 C CB  . GLU   A 1 253 ? -19.81322 -26.36268 -26.34543 1.000 10.42110 ? 235  GLU   A CB  1 
ATOM   1709 C CG  . GLU   A 1 253 ? -20.27415 -26.33548 -24.88655 1.000 16.65856 ? 235  GLU   A CG  1 
ATOM   1710 C CD  . GLU   A 1 253 ? -21.01737 -27.58382 -24.42334 1.000 22.26887 ? 235  GLU   A CD  1 
ATOM   1711 O OE1 . GLU   A 1 253 ? -21.07941 -28.58943 -25.16770 1.000 17.87906 ? 235  GLU   A OE1 1 
ATOM   1712 O OE2 . GLU   A 1 253 ? -21.55118 -27.54543 -23.29591 1.000 19.85381 ? 235  GLU   A OE2 1 
ATOM   1713 N N   . VAL   A 1 254 ? -19.67838 -25.10631 -29.40841 1.000 14.06718 ? 236  VAL   A N   1 
ATOM   1714 C CA  . VAL   A 1 254 ? -19.01817 -24.86499 -30.68738 1.000 16.08508 ? 236  VAL   A CA  1 
ATOM   1715 C C   . VAL   A 1 254 ? -18.73771 -23.37648 -30.86257 1.000 16.43075 ? 236  VAL   A C   1 
ATOM   1716 O O   . VAL   A 1 254 ? -17.63963 -22.97433 -31.27327 1.000 12.65415 ? 236  VAL   A O   1 
ATOM   1717 C CB  . VAL   A 1 254 ? -19.86828 -25.42193 -31.84478 1.000 15.17981 ? 236  VAL   A CB  1 
ATOM   1718 C CG1 . VAL   A 1 254 ? -19.20192 -25.14553 -33.17277 1.000 13.72034 ? 236  VAL   A CG1 1 
ATOM   1719 C CG2 . VAL   A 1 254 ? -20.08853 -26.92026 -31.66034 1.000 16.83585 ? 236  VAL   A CG2 1 
ATOM   1720 N N   . ALA   A 1 255 ? -19.73169 -22.53594 -30.56406 1.000 14.00527 ? 237  ALA   A N   1 
ATOM   1721 C CA  . ALA   A 1 255 ? -19.52044 -21.09549 -30.65492 1.000 11.57596 ? 237  ALA   A CA  1 
ATOM   1722 C C   . ALA   A 1 255 ? -18.37819 -20.64761 -29.75045 1.000 12.92222 ? 237  ALA   A C   1 
ATOM   1723 O O   . ALA   A 1 255 ? -17.62782 -19.72474 -30.10191 1.000 11.85933 ? 237  ALA   A O   1 
ATOM   1724 C CB  . ALA   A 1 255 ? -20.81422 -20.34664 -30.30933 1.000 12.25083 ? 237  ALA   A CB  1 
ATOM   1725 N N   . PHE   A 1 256 ? -18.23207 -21.28756 -28.58214 1.000 12.19222 ? 238  PHE   A N   1 
ATOM   1726 C CA  . PHE   A 1 256 ? -17.13351 -20.95495 -27.67764 1.000 16.17872 ? 238  PHE   A CA  1 
ATOM   1727 C C   . PHE   A 1 256 ? -15.78112 -21.20638 -28.32648 1.000 15.00706 ? 238  PHE   A C   1 
ATOM   1728 O O   . PHE   A 1 256 ? -14.90008 -20.33904 -28.30783 1.000 11.82526 ? 238  PHE   A O   1 
ATOM   1729 C CB  . PHE   A 1 256 ? -17.24111 -21.75393 -26.37432 1.000 15.22003 ? 238  PHE   A CB  1 
ATOM   1730 C CG  . PHE   A 1 256 ? -16.09310 -21.50726 -25.42211 1.000 18.78553 ? 238  PHE   A CG  1 
ATOM   1731 C CD1 . PHE   A 1 256 ? -16.08277 -20.39483 -24.58977 1.000 14.77026 ? 238  PHE   A CD1 1 
ATOM   1732 C CD2 . PHE   A 1 256 ? -15.01196 -22.37787 -25.37631 1.000 12.47743 ? 238  PHE   A CD2 1 
ATOM   1733 C CE1 . PHE   A 1 256 ? -15.03008 -20.17121 -23.71667 1.000 19.27028 ? 238  PHE   A CE1 1 
ATOM   1734 C CE2 . PHE   A 1 256 ? -13.95259 -22.15210 -24.51451 1.000 12.29584 ? 238  PHE   A CE2 1 
ATOM   1735 C CZ  . PHE   A 1 256 ? -13.96041 -21.05553 -23.68408 1.000 15.44386 ? 238  PHE   A CZ  1 
ATOM   1736 N N   . MET   A 1 257 ? -15.58303 -22.41183 -28.86599 1.000 12.15190 ? 239  MET   A N   1 
ATOM   1737 C CA  . MET   A 1 257 ? -14.30374 -22.74400 -29.48068 1.000 14.94930 ? 239  MET   A CA  1 
ATOM   1738 C C   . MET   A 1 257 ? -14.01008 -21.83873 -30.67254 1.000 11.80278 ? 239  MET   A C   1 
ATOM   1739 O O   . MET   A 1 257 ? -12.83725 -21.56842 -30.97432 1.000 11.41697 ? 239  MET   A O   1 
ATOM   1740 C CB  . MET   A 1 257 ? -14.31209 -24.23079 -29.86276 1.000 12.50914 ? 239  MET   A CB  1 
ATOM   1741 C CG  . MET   A 1 257 ? -14.70750 -24.51228 -31.29574 1.000 13.59352 ? 239  MET   A CG  1 
ATOM   1742 S SD  . MET   A 1 257 ? -14.56257 -26.26396 -31.77936 1.000 16.40706 ? 239  MET   A SD  1 
ATOM   1743 C CE  . MET   A 1 257 ? -15.66753 -27.10659 -30.65784 1.000 18.30488 ? 239  MET   A CE  1 
ATOM   1744 N N   . VAL   A 1 258 ? -15.06089 -21.33579 -31.33535 1.000 12.14365 ? 240  VAL   A N   1 
ATOM   1745 C CA  . VAL   A 1 258 ? -14.88787 -20.40481 -32.44703 1.000 10.32112 ? 240  VAL   A CA  1 
ATOM   1746 C C   . VAL   A 1 258 ? -14.43923 -19.03837 -31.93309 1.000 10.62431 ? 240  VAL   A C   1 
ATOM   1747 O O   . VAL   A 1 258 ? -13.51628 -18.42655 -32.48079 1.000 13.22830 ? 240  VAL   A O   1 
ATOM   1748 C CB  . VAL   A 1 258 ? -16.18419 -20.29505 -33.27392 1.000 12.62471 ? 240  VAL   A CB  1 
ATOM   1749 C CG1 . VAL   A 1 258 ? -16.04273 -19.18841 -34.31670 1.000 12.39751 ? 240  VAL   A CG1 1 
ATOM   1750 C CG2 . VAL   A 1 258 ? -16.50546 -21.63487 -33.95779 1.000 10.64524 ? 240  VAL   A CG2 1 
ATOM   1751 N N   . CYS   A 1 259 ? -15.09372 -18.53335 -30.88079 1.000 12.68969 ? 241  CYS   A N   1 
ATOM   1752 C CA  . CYS   A 1 259 ? -14.59401 -17.32883 -30.21816 1.000 10.94129 ? 241  CYS   A CA  1 
ATOM   1753 C C   . CYS   A 1 259 ? -13.17368 -17.52172 -29.70907 1.000 11.11388 ? 241  CYS   A C   1 
ATOM   1754 O O   . CYS   A 1 259 ? -12.39923 -16.55626 -29.64367 1.000 8.91532  ? 241  CYS   A O   1 
ATOM   1755 C CB  . CYS   A 1 259 ? -15.50912 -16.94350 -29.05790 1.000 12.98927 ? 241  CYS   A CB  1 
ATOM   1756 S SG  . CYS   A 1 259 ? -17.09943 -16.33446 -29.59864 1.000 15.90717 ? 241  CYS   A SG  1 
ATOM   1757 N N   . ALA   A 1 260 ? -12.82379 -18.75608 -29.34121 1.000 10.88996 ? 242  ALA   A N   1 
ATOM   1758 C CA  . ALA   A 1 260 ? -11.50672 -19.08065 -28.79461 1.000 14.96119 ? 242  ALA   A CA  1 
ATOM   1759 C C   . ALA   A 1 260 ? -10.38846 -19.01928 -29.82701 1.000 16.57193 ? 242  ALA   A C   1 
ATOM   1760 O O   . ALA   A 1 260 ? -9.21097  -19.04420 -29.44132 1.000 11.59945 ? 242  ALA   A O   1 
ATOM   1761 C CB  . ALA   A 1 260 ? -11.53674 -20.47594 -28.16353 1.000 12.59427 ? 242  ALA   A CB  1 
ATOM   1762 N N   . ILE   A 1 261 ? -10.71303 -18.96399 -31.12156 1.000 12.52449 ? 243  ILE   A N   1 
ATOM   1763 C CA  . ILE   A 1 261 ? -9.66741  -18.80525 -32.11793 1.000 11.28503 ? 243  ILE   A CA  1 
ATOM   1764 C C   . ILE   A 1 261 ? -8.85071  -17.57909 -31.76104 1.000 16.37152 ? 243  ILE   A C   1 
ATOM   1765 O O   . ILE   A 1 261 ? -9.41010  -16.53436 -31.41446 1.000 13.46810 ? 243  ILE   A O   1 
ATOM   1766 C CB  . ILE   A 1 261 ? -10.28262 -18.69522 -33.52433 1.000 14.74263 ? 243  ILE   A CB  1 
ATOM   1767 C CG1 . ILE   A 1 261 ? -11.03621 -19.97833 -33.88683 1.000 14.36839 ? 243  ILE   A CG1 1 
ATOM   1768 C CG2 . ILE   A 1 261 ? -9.20813  -18.35113 -34.55000 1.000 16.59886 ? 243  ILE   A CG2 1 
ATOM   1769 C CD1 . ILE   A 1 261 ? -11.87429 -19.85204 -35.17404 1.000 13.42520 ? 243  ILE   A CD1 1 
ATOM   1770 N N   . ASN   A 1 262 ? -7.52637  -17.71896 -31.76670 1.000 13.90609 ? 244  ASN   A N   1 
ATOM   1771 C CA  . ASN   A 1 262 ? -6.63160  -16.60463 -31.44442 1.000 13.19051 ? 244  ASN   A CA  1 
ATOM   1772 C C   . ASN   A 1 262 ? -5.76617  -16.29492 -32.65715 1.000 14.50566 ? 244  ASN   A C   1 
ATOM   1773 O O   . ASN   A 1 262 ? -4.78412  -17.01227 -32.92357 1.000 17.91303 ? 244  ASN   A O   1 
ATOM   1774 C CB  . ASN   A 1 262 ? -5.76101  -16.91756 -30.22606 1.000 11.77819 ? 244  ASN   A CB  1 
ATOM   1775 C CG  . ASN   A 1 262 ? -4.95545  -15.71523 -29.76665 1.000 19.40199 ? 244  ASN   A CG  1 
ATOM   1776 O OD1 . ASN   A 1 262 ? -4.76000  -14.76900 -30.52507 1.000 17.82538 ? 244  ASN   A OD1 1 
ATOM   1777 N ND2 . ASN   A 1 262 ? -4.49955  -15.73545 -28.51588 1.000 16.46950 ? 244  ASN   A ND2 1 
ATOM   1778 N N   . PRO   A 1 263 ? -6.06873  -15.23132 -33.40572 1.000 14.34019 ? 245  PRO   A N   1 
ATOM   1779 C CA  . PRO   A 1 263 ? -5.32562  -14.94412 -34.64024 1.000 18.67095 ? 245  PRO   A CA  1 
ATOM   1780 C C   . PRO   A 1 263 ? -3.96517  -14.30333 -34.43176 1.000 16.46874 ? 245  PRO   A C   1 
ATOM   1781 O O   . PRO   A 1 263 ? -3.25952  -14.07987 -35.42193 1.000 18.47391 ? 245  PRO   A O   1 
ATOM   1782 C CB  . PRO   A 1 263 ? -6.26099  -13.97651 -35.38974 1.000 20.56636 ? 245  PRO   A CB  1 
ATOM   1783 C CG  . PRO   A 1 263 ? -7.62256  -14.16345 -34.74306 1.000 21.73535 ? 245  PRO   A CG  1 
ATOM   1784 C CD  . PRO   A 1 263 ? -7.28158  -14.40738 -33.29748 1.000 19.59425 ? 245  PRO   A CD  1 
ATOM   1785 N N   . SER   A 1 264 ? -3.57360  -13.99882 -33.19465 1.000 20.19942 ? 246  SER   A N   1 
ATOM   1786 C CA  . SER   A 1 264 ? -2.31122  -13.30226 -32.96056 1.000 18.98880 ? 246  SER   A CA  1 
ATOM   1787 C C   . SER   A 1 264 ? -1.13744  -14.15419 -33.40687 1.000 19.00336 ? 246  SER   A C   1 
ATOM   1788 O O   . SER   A 1 264 ? -0.95110  -15.26977 -32.91552 1.000 20.68872 ? 246  SER   A O   1 
ATOM   1789 C CB  . SER   A 1 264 ? -2.14744  -12.95023 -31.47981 1.000 20.20732 ? 246  SER   A CB  1 
ATOM   1790 O OG  . SER   A 1 264 ? -3.14875  -12.05842 -31.04271 1.000 29.27171 ? 246  SER   A OG  1 
ATOM   1791 N N   . ILE   A 1 265 ? -0.34266  -13.62157 -34.33380 1.000 19.49268 ? 247  ILE   A N   1 
ATOM   1792 C CA  . ILE   A 1 265 ? 0.97128   -14.18930 -34.61674 1.000 21.18495 ? 247  ILE   A CA  1 
ATOM   1793 C C   . ILE   A 1 265 ? 1.99872   -13.64205 -33.63541 1.000 24.02946 ? 247  ILE   A C   1 
ATOM   1794 O O   . ILE   A 1 265 ? 2.76734   -14.39234 -33.02654 1.000 30.14893 ? 247  ILE   A O   1 
ATOM   1795 C CB  . ILE   A 1 265 ? 1.37479   -13.89802 -36.07502 1.000 24.83674 ? 247  ILE   A CB  1 
ATOM   1796 C CG1 . ILE   A 1 265 ? 0.46050   -14.65425 -37.03776 1.000 18.64076 ? 247  ILE   A CG1 1 
ATOM   1797 C CG2 . ILE   A 1 265 ? 2.83743   -14.26936 -36.30916 1.000 25.91648 ? 247  ILE   A CG2 1 
ATOM   1798 C CD1 . ILE   A 1 265 ? 0.32490   -13.98843 -38.38647 1.000 24.70725 ? 247  ILE   A CD1 1 
ATOM   1799 N N   . ASP   A 1 266 ? 2.02495   -12.32393 -33.47490 1.000 25.31577 ? 248  ASP   A N   1 
ATOM   1800 C CA  . ASP   A 1 266 ? 2.78286   -11.65412 -32.42690 1.000 33.19164 ? 248  ASP   A CA  1 
ATOM   1801 C C   . ASP   A 1 266 ? 1.95040   -10.46803 -31.95447 1.000 29.91455 ? 248  ASP   A C   1 
ATOM   1802 O O   . ASP   A 1 266 ? 0.80308   -10.28418 -32.37846 1.000 26.02863 ? 248  ASP   A O   1 
ATOM   1803 C CB  . ASP   A 1 266 ? 4.18595   -11.27258 -32.92582 1.000 36.71993 ? 248  ASP   A CB  1 
ATOM   1804 C CG  . ASP   A 1 266 ? 4.16115   -10.34093 -34.13799 1.000 27.89200 ? 248  ASP   A CG  1 
ATOM   1805 O OD1 . ASP   A 1 266 ? 3.21594   -9.54767  -34.29635 1.000 36.62456 ? 248  ASP   A OD1 1 
ATOM   1806 O OD2 . ASP   A 1 266 ? 5.09831   -10.41915 -34.95733 1.000 35.89208 ? 248  ASP   A OD2 1 
ATOM   1807 N N   . LEU   A 1 267 ? 2.53492   -9.63808  -31.08809 1.000 32.50060 ? 249  LEU   A N   1 
ATOM   1808 C CA  . LEU   A 1 267 ? 1.75969   -8.56848  -30.46483 1.000 32.89310 ? 249  LEU   A CA  1 
ATOM   1809 C C   . LEU   A 1 267 ? 1.20261   -7.59060  -31.49015 1.000 34.85489 ? 249  LEU   A C   1 
ATOM   1810 O O   . LEU   A 1 267 ? 0.14864   -6.98795  -31.26032 1.000 33.55426 ? 249  LEU   A O   1 
ATOM   1811 C CB  . LEU   A 1 267 ? 2.61918   -7.82190  -29.44142 1.000 48.06711 ? 249  LEU   A CB  1 
ATOM   1812 C CG  . LEU   A 1 267 ? 2.81628   -8.44534  -28.05551 1.000 40.41767 ? 249  LEU   A CG  1 
ATOM   1813 C CD1 . LEU   A 1 267 ? 3.32981   -7.39837  -27.07269 1.000 29.63296 ? 249  LEU   A CD1 1 
ATOM   1814 C CD2 . LEU   A 1 267 ? 1.53002   -9.08429  -27.53725 1.000 39.02513 ? 249  LEU   A CD2 1 
ATOM   1815 N N   . HIS   A 1 268 ? 1.87738   -7.42673  -32.62629 1.000 31.91784 ? 250  HIS   A N   1 
ATOM   1816 C CA  . HIS   A 1 268 ? 1.48923   -6.42778  -33.61282 1.000 40.38278 ? 250  HIS   A CA  1 
ATOM   1817 C C   . HIS   A 1 268 ? 0.87056   -7.01656  -34.87340 1.000 36.55543 ? 250  HIS   A C   1 
ATOM   1818 O O   . HIS   A 1 268 ? 0.50140   -6.25325  -35.77073 1.000 39.72230 ? 250  HIS   A O   1 
ATOM   1819 C CB  . HIS   A 1 268 ? 2.70257   -5.56984  -34.00063 1.000 36.51493 ? 250  HIS   A CB  1 
ATOM   1820 N N   . THR   A 1 269 ? 0.74463   -8.33965  -34.98092 1.000 30.83181 ? 251  THR   A N   1 
ATOM   1821 C CA  . THR   A 1 269 ? 0.33445   -8.94616  -36.24355 1.000 27.22553 ? 251  THR   A CA  1 
ATOM   1822 C C   . THR   A 1 269 ? -0.69430  -10.03663 -35.99497 1.000 22.00396 ? 251  THR   A C   1 
ATOM   1823 O O   . THR   A 1 269 ? -0.43175  -10.98397 -35.24721 1.000 21.06322 ? 251  THR   A O   1 
ATOM   1824 C CB  . THR   A 1 269 ? 1.53757   -9.52066  -36.99823 1.000 30.64870 ? 251  THR   A CB  1 
ATOM   1825 O OG1 . THR   A 1 269 ? 2.60105   -8.56198  -37.00336 1.000 37.11409 ? 251  THR   A OG1 1 
ATOM   1826 C CG2 . THR   A 1 269 ? 1.15392   -9.83462  -38.43092 1.000 35.88533 ? 251  THR   A CG2 1 
ATOM   1827 N N   . ASP   A 1 270 ? -1.84993  -9.90497  -36.64096 1.000 22.87014 ? 252  ASP   A N   1 
ATOM   1828 C CA  . ASP   A 1 270 ? -2.90012  -10.91246 -36.62213 1.000 23.00872 ? 252  ASP   A CA  1 
ATOM   1829 C C   . ASP   A 1 270 ? -2.87071  -11.68281 -37.93397 1.000 25.56961 ? 252  ASP   A C   1 
ATOM   1830 O O   . ASP   A 1 270 ? -2.59238  -11.11062 -38.99155 1.000 29.45204 ? 252  ASP   A O   1 
ATOM   1831 C CB  . ASP   A 1 270 ? -4.27538  -10.26733 -36.44360 1.000 23.58816 ? 252  ASP   A CB  1 
ATOM   1832 C CG  . ASP   A 1 270 ? -4.52721  -9.80651  -35.02385 1.000 30.23272 ? 252  ASP   A CG  1 
ATOM   1833 O OD1 . ASP   A 1 270 ? -3.83017  -10.28694 -34.10708 1.000 23.90838 ? 252  ASP   A OD1 1 
ATOM   1834 O OD2 . ASP   A 1 270 ? -5.42558  -8.96154  -34.82963 1.000 31.78648 ? 252  ASP   A OD2 1 
ATOM   1835 N N   . SER   A 1 271 ? -3.15881  -12.97683 -37.86822 1.000 18.28585 ? 253  SER   A N   1 
ATOM   1836 C CA  . SER   A 1 271 ? -3.28677  -13.75909 -39.09025 1.000 20.75201 ? 253  SER   A CA  1 
ATOM   1837 C C   . SER   A 1 271 ? -4.60113  -13.40979 -39.77611 1.000 19.09193 ? 253  SER   A C   1 
ATOM   1838 O O   . SER   A 1 271 ? -5.68247  -13.58381 -39.19749 1.000 16.81748 ? 253  SER   A O   1 
ATOM   1839 C CB  . SER   A 1 271 ? -3.21452  -15.25647 -38.79162 1.000 16.77693 ? 253  SER   A CB  1 
ATOM   1840 O OG  . SER   A 1 271 ? -3.97843  -16.00317 -39.72862 1.000 15.39962 ? 253  SER   A OG  1 
ATOM   1841 N N   . LEU   A 1 272 ? -4.50304  -12.90152 -41.00920 1.000 18.76508 ? 254  LEU   A N   1 
ATOM   1842 C CA  . LEU   A 1 272 ? -5.69589  -12.62695 -41.80514 1.000 20.83586 ? 254  LEU   A CA  1 
ATOM   1843 C C   . LEU   A 1 272 ? -6.54487  -13.87699 -41.97060 1.000 15.23969 ? 254  LEU   A C   1 
ATOM   1844 O O   . LEU   A 1 272 ? -7.78080  -13.81085 -41.92970 1.000 17.17116 ? 254  LEU   A O   1 
ATOM   1845 C CB  . LEU   A 1 272 ? -5.29063  -12.08691 -43.17755 1.000 15.80690 ? 254  LEU   A CB  1 
ATOM   1846 C CG  . LEU   A 1 272 ? -4.61575  -10.72254 -43.25481 1.000 22.94858 ? 254  LEU   A CG  1 
ATOM   1847 C CD1 . LEU   A 1 272 ? -4.11648  -10.47832 -44.67188 1.000 28.55359 ? 254  LEU   A CD1 1 
ATOM   1848 C CD2 . LEU   A 1 272 ? -5.58875  -9.64645  -42.84462 1.000 23.59480 ? 254  LEU   A CD2 1 
ATOM   1849 N N   . GLU   A 1 273 ? -5.89541  -15.02534 -42.17485 1.000 16.40580 ? 255  GLU   A N   1 
ATOM   1850 C CA  . GLU   A 1 273 ? -6.62229  -16.26901 -42.41389 1.000 14.36266 ? 255  GLU   A CA  1 
ATOM   1851 C C   . GLU   A 1 273 ? -7.46313  -16.66320 -41.20414 1.000 13.82339 ? 255  GLU   A C   1 
ATOM   1852 O O   . GLU   A 1 273 ? -8.62001  -17.07007 -41.35036 1.000 18.61007 ? 255  GLU   A O   1 
ATOM   1853 C CB  . GLU   A 1 273 ? -5.63217  -17.38370 -42.77183 1.000 15.82077 ? 255  GLU   A CB  1 
ATOM   1854 C CG  . GLU   A 1 273 ? -4.66017  -17.01775 -43.91667 1.000 19.84142 ? 255  GLU   A CG  1 
ATOM   1855 C CD  . GLU   A 1 273 ? -3.36637  -16.38108 -43.43670 1.000 20.65933 ? 255  GLU   A CD  1 
ATOM   1856 O OE1 . GLU   A 1 273 ? -3.34706  -15.81970 -42.31565 1.000 20.99678 ? 255  GLU   A OE1 1 
ATOM   1857 O OE2 . GLU   A 1 273 ? -2.36607  -16.41254 -44.19306 1.000 16.62579 ? 255  GLU   A OE2 1 
ATOM   1858 N N   . LEU   A 1 274 ? -6.89465  -16.56220 -40.00115 1.000 17.58651 ? 256  LEU   A N   1 
ATOM   1859 C CA  . LEU   A 1 274 ? -7.63081  -16.96133 -38.80485 1.000 16.01583 ? 256  LEU   A CA  1 
ATOM   1860 C C   . LEU   A 1 274 ? -8.77703  -15.99520 -38.51008 1.000 16.04953 ? 256  LEU   A C   1 
ATOM   1861 O O   . LEU   A 1 274 ? -9.84751  -16.41756 -38.05673 1.000 14.52151 ? 256  LEU   A O   1 
ATOM   1862 C CB  . LEU   A 1 274 ? -6.67720  -17.06091 -37.61025 1.000 16.58925 ? 256  LEU   A CB  1 
ATOM   1863 C CG  . LEU   A 1 274 ? -5.70084  -18.24739 -37.65284 1.000 14.26735 ? 256  LEU   A CG  1 
ATOM   1864 C CD1 . LEU   A 1 274 ? -4.68539  -18.17743 -36.50578 1.000 12.21560 ? 256  LEU   A CD1 1 
ATOM   1865 C CD2 . LEU   A 1 274 ? -6.46068  -19.55672 -37.61910 1.000 14.80687 ? 256  LEU   A CD2 1 
ATOM   1866 N N   . LEU   A 1 275 ? -8.57444  -14.69668 -38.76040 1.000 16.37937 ? 257  LEU   A N   1 
ATOM   1867 C CA  . LEU   A 1 275 ? -9.67814  -13.74429 -38.65174 1.000 21.80916 ? 257  LEU   A CA  1 
ATOM   1868 C C   . LEU   A 1 275 ? -10.80388 -14.10253 -39.61551 1.000 19.99675 ? 257  LEU   A C   1 
ATOM   1869 O O   . LEU   A 1 275 ? -11.98296 -14.11061 -39.24262 1.000 15.77432 ? 257  LEU   A O   1 
ATOM   1870 C CB  . LEU   A 1 275 ? -9.17593  -12.32362 -38.91989 1.000 18.30851 ? 257  LEU   A CB  1 
ATOM   1871 C CG  . LEU   A 1 275 ? -8.33178  -11.72970 -37.79597 1.000 20.41540 ? 257  LEU   A CG  1 
ATOM   1872 C CD1 . LEU   A 1 275 ? -7.50164  -10.56780 -38.29787 1.000 19.95755 ? 257  LEU   A CD1 1 
ATOM   1873 C CD2 . LEU   A 1 275 ? -9.22353  -11.30803 -36.64030 1.000 24.97635 ? 257  LEU   A CD2 1 
ATOM   1874 N N   . GLN   A 1 276 ? -10.44866 -14.41797 -40.86357 1.000 16.83145 ? 258  GLN   A N   1 
ATOM   1875 C CA  . GLN   A 1 276 ? -11.45012 -14.75737 -41.86737 1.000 16.72290 ? 258  GLN   A CA  1 
ATOM   1876 C C   . GLN   A 1 276 ? -12.16551 -16.05466 -41.50971 1.000 19.86518 ? 258  GLN   A C   1 
ATOM   1877 O O   . GLN   A 1 276 ? -13.37713 -16.18272 -41.71925 1.000 21.28167 ? 258  GLN   A O   1 
ATOM   1878 C CB  . GLN   A 1 276 ? -10.77463 -14.86066 -43.24020 1.000 20.27768 ? 258  GLN   A CB  1 
ATOM   1879 C CG  . GLN   A 1 276 ? -11.66295 -15.21070 -44.44945 1.000 32.49228 ? 258  GLN   A CG  1 
ATOM   1880 C CD  . GLN   A 1 276 ? -12.79255 -14.20946 -44.71936 1.000 33.20256 ? 258  GLN   A CD  1 
ATOM   1881 O OE1 . GLN   A 1 276 ? -12.84124 -13.60782 -45.79329 1.000 48.94658 ? 258  GLN   A OE1 1 
ATOM   1882 N NE2 . GLN   A 1 276 ? -13.73581 -14.08833 -43.79161 1.000 47.42826 ? 258  GLN   A NE2 1 
ATOM   1883 N N   . LEU   A 1 277 ? -11.43284 -17.02574 -40.95866 1.000 15.92161 ? 259  LEU   A N   1 
ATOM   1884 C CA  . LEU   A 1 277 ? -12.04711 -18.27471 -40.52946 1.000 16.89643 ? 259  LEU   A CA  1 
ATOM   1885 C C   . LEU   A 1 277 ? -13.03737 -18.03555 -39.39534 1.000 17.36849 ? 259  LEU   A C   1 
ATOM   1886 O O   . LEU   A 1 277 ? -14.17768 -18.50922 -39.44103 1.000 15.03218 ? 259  LEU   A O   1 
ATOM   1887 C CB  . LEU   A 1 277 ? -10.96358 -19.27031 -40.10090 1.000 16.36292 ? 259  LEU   A CB  1 
ATOM   1888 C CG  . LEU   A 1 277 ? -11.46560 -20.58963 -39.50765 1.000 19.15597 ? 259  LEU   A CG  1 
ATOM   1889 C CD1 . LEU   A 1 277 ? -12.34015 -21.33670 -40.50199 1.000 21.18561 ? 259  LEU   A CD1 1 
ATOM   1890 C CD2 . LEU   A 1 277 ? -10.29212 -21.46905 -39.05067 1.000 19.64430 ? 259  LEU   A CD2 1 
ATOM   1891 N N   . GLN   A 1 278 ? -12.60842 -17.31027 -38.35846 1.000 15.67466 ? 260  GLN   A N   1 
ATOM   1892 C CA  . GLN   A 1 278 ? -13.51141 -16.97618 -37.26091 1.000 17.61802 ? 260  GLN   A CA  1 
ATOM   1893 C C   . GLN   A 1 278 ? -14.77129 -16.28290 -37.76754 1.000 12.28982 ? 260  GLN   A C   1 
ATOM   1894 O O   . GLN   A 1 278 ? -15.88870 -16.61403 -37.34948 1.000 15.45752 ? 260  GLN   A O   1 
ATOM   1895 C CB  . GLN   A 1 278 ? -12.79511 -16.08536 -36.24680 1.000 15.53475 ? 260  GLN   A CB  1 
ATOM   1896 C CG  . GLN   A 1 278 ? -13.57077 -15.90111 -34.95375 1.000 18.28360 ? 260  GLN   A CG  1 
ATOM   1897 C CD  . GLN   A 1 278 ? -12.82192 -15.03421 -33.95440 1.000 15.61474 ? 260  GLN   A CD  1 
ATOM   1898 O OE1 . GLN   A 1 278 ? -12.51167 -13.87212 -34.22790 1.000 15.25163 ? 260  GLN   A OE1 1 
ATOM   1899 N NE2 . GLN   A 1 278 ? -12.50265 -15.60898 -32.80151 1.000 14.14399 ? 260  GLN   A NE2 1 
ATOM   1900 N N   . GLN   A 1 279 ? -14.59803 -15.31924 -38.67394 1.000 16.97315 ? 261  GLN   A N   1 
ATOM   1901 C CA  . GLN   A 1 279 ? -15.72128 -14.53220 -39.17622 1.000 15.54561 ? 261  GLN   A CA  1 
ATOM   1902 C C   . GLN   A 1 279 ? -16.73256 -15.40735 -39.90863 1.000 21.01786 ? 261  GLN   A C   1 
ATOM   1903 O O   . GLN   A 1 279 ? -17.93802 -15.34311 -39.63224 1.000 13.76213 ? 261  GLN   A O   1 
ATOM   1904 C CB  . GLN   A 1 279 ? -15.20679 -13.42346 -40.08813 1.000 16.50302 ? 261  GLN   A CB  1 
ATOM   1905 C CG  . GLN   A 1 279 ? -16.26260 -12.41380 -40.50088 1.000 14.23126 ? 261  GLN   A CG  1 
ATOM   1906 C CD  . GLN   A 1 279 ? -15.65171 -11.23705 -41.21828 1.000 26.21473 ? 261  GLN   A CD  1 
ATOM   1907 O OE1 . GLN   A 1 279 ? -14.51864 -11.31003 -41.68860 1.000 26.48961 ? 261  GLN   A OE1 1 
ATOM   1908 N NE2 . GLN   A 1 279 ? -16.39090 -10.14278 -41.30589 1.000 22.08147 ? 261  GLN   A NE2 1 
ATOM   1909 N N   . LYS   A 1 280 ? -16.26091 -16.23621 -40.85070 1.000 15.41050 ? 262  LYS   A N   1 
ATOM   1910 C CA  . LYS   A 1 280 ? -17.17728 -17.12014 -41.56922 1.000 15.40391 ? 262  LYS   A CA  1 
ATOM   1911 C C   . LYS   A 1 280 ? -17.85375 -18.10253 -40.61998 1.000 16.39831 ? 262  LYS   A C   1 
ATOM   1912 O O   . LYS   A 1 280 ? -19.04648 -18.39281 -40.76395 1.000 16.20211 ? 262  LYS   A O   1 
ATOM   1913 C CB  . LYS   A 1 280 ? -16.43164 -17.86385 -42.68380 1.000 15.13536 ? 262  LYS   A CB  1 
ATOM   1914 C CG  . LYS   A 1 280 ? -15.96247 -16.98060 -43.83752 1.000 23.04591 ? 262  LYS   A CG  1 
ATOM   1915 C CD  . LYS   A 1 280 ? -15.85110 -17.77165 -45.14748 1.000 35.55719 ? 262  LYS   A CD  1 
ATOM   1916 C CE  . LYS   A 1 280 ? -15.19435 -16.94905 -46.25855 1.000 41.78944 ? 262  LYS   A CE  1 
ATOM   1917 N NZ  . LYS   A 1 280 ? -14.10077 -17.67338 -46.98518 1.000 48.20530 ? 262  LYS   A NZ  1 
ATOM   1918 N N   . LEU   A 1 281 ? -17.12012 -18.59629 -39.61524 1.000 13.71383 ? 263  LEU   A N   1 
ATOM   1919 C CA  . LEU   A 1 281 ? -17.70487 -19.56516 -38.69311 1.000 13.07920 ? 263  LEU   A CA  1 
ATOM   1920 C C   . LEU   A 1 281 ? -18.74393 -18.91554 -37.78139 1.000 14.90274 ? 263  LEU   A C   1 
ATOM   1921 O O   . LEU   A 1 281 ? -19.77078 -19.52888 -37.47063 1.000 14.56387 ? 263  LEU   A O   1 
ATOM   1922 C CB  . LEU   A 1 281 ? -16.60764 -20.23582 -37.86438 1.000 17.64628 ? 263  LEU   A CB  1 
ATOM   1923 C CG  . LEU   A 1 281 ? -15.82543 -21.36346 -38.55384 1.000 15.94177 ? 263  LEU   A CG  1 
ATOM   1924 C CD1 . LEU   A 1 281 ? -14.73573 -21.93181 -37.61989 1.000 13.94272 ? 263  LEU   A CD1 1 
ATOM   1925 C CD2 . LEU   A 1 281 ? -16.74397 -22.46771 -39.07343 1.000 12.87800 ? 263  LEU   A CD2 1 
ATOM   1926 N N   . LEU   A 1 282 ? -18.49012 -17.68313 -37.33435 1.000 18.67777 ? 264  LEU   A N   1 
ATOM   1927 C CA  . LEU   A 1 282 ? -19.46220 -16.98522 -36.49513 1.000 12.31881 ? 264  LEU   A CA  1 
ATOM   1928 C C   . LEU   A 1 282 ? -20.74853 -16.70110 -37.25880 1.000 14.35894 ? 264  LEU   A C   1 
ATOM   1929 O O   . LEU   A 1 282 ? -21.84445 -16.78709 -36.69364 1.000 14.72837 ? 264  LEU   A O   1 
ATOM   1930 C CB  . LEU   A 1 282 ? -18.85872 -15.67950 -35.96415 1.000 11.81800 ? 264  LEU   A CB  1 
ATOM   1931 C CG  . LEU   A 1 282 ? -17.90829 -15.85416 -34.77183 1.000 16.01059 ? 264  LEU   A CG  1 
ATOM   1932 C CD1 . LEU   A 1 282 ? -17.29836 -14.52546 -34.32917 1.000 15.10640 ? 264  LEU   A CD1 1 
ATOM   1933 C CD2 . LEU   A 1 282 ? -18.62740 -16.54172 -33.61055 1.000 11.15113 ? 264  LEU   A CD2 1 
ATOM   1934 N N   . TRP   A 1 283 ? -20.63597 -16.34620 -38.54137 1.000 16.28055 ? 265  TRP   A N   1 
ATOM   1935 C CA  . TRP   A 1 283 ? -21.83247 -16.11206 -39.34565 1.000 17.58018 ? 265  TRP   A CA  1 
ATOM   1936 C C   . TRP   A 1 283 ? -22.63151 -17.39309 -39.52422 1.000 20.18291 ? 265  TRP   A C   1 
ATOM   1937 O O   . TRP   A 1 283 ? -23.87075 -17.37309 -39.50030 1.000 23.50557 ? 265  TRP   A O   1 
ATOM   1938 C CB  . TRP   A 1 283 ? -21.44787 -15.52119 -40.70406 1.000 18.31987 ? 265  TRP   A CB  1 
ATOM   1939 C CG  . TRP   A 1 283 ? -21.33624 -14.00767 -40.68900 1.000 22.23697 ? 265  TRP   A CG  1 
ATOM   1940 C CD1 . TRP   A 1 283 ? -20.26520 -13.25866 -41.08993 1.000 12.92963 ? 265  TRP   A CD1 1 
ATOM   1941 C CD2 . TRP   A 1 283 ? -22.33413 -13.07476 -40.24957 1.000 15.67116 ? 265  TRP   A CD2 1 
ATOM   1942 N NE1 . TRP   A 1 283 ? -20.53102 -11.91882 -40.92262 1.000 16.40083 ? 265  TRP   A NE1 1 
ATOM   1943 C CE2 . TRP   A 1 283 ? -21.79457 -11.78113 -40.40510 1.000 18.45028 ? 265  TRP   A CE2 1 
ATOM   1944 C CE3 . TRP   A 1 283 ? -23.62472 -13.20924 -39.73052 1.000 14.74260 ? 265  TRP   A CE3 1 
ATOM   1945 C CZ2 . TRP   A 1 283 ? -22.50530 -10.62926 -40.06535 1.000 12.43114 ? 265  TRP   A CZ2 1 
ATOM   1946 C CZ3 . TRP   A 1 283 ? -24.32579 -12.06784 -39.39388 1.000 18.85971 ? 265  TRP   A CZ3 1 
ATOM   1947 C CH2 . TRP   A 1 283 ? -23.76974 -10.79592 -39.56921 1.000 18.80555 ? 265  TRP   A CH2 1 
ATOM   1948 N N   . LEU   A 1 284 ? -21.93735 -18.51695 -39.72759 1.000 15.18101 ? 266  LEU   A N   1 
ATOM   1949 C CA  . LEU   A 1 284 ? -22.60125 -19.81410 -39.79629 1.000 16.87217 ? 266  LEU   A CA  1 
ATOM   1950 C C   . LEU   A 1 284 ? -23.38501 -20.09037 -38.51830 1.000 20.66177 ? 266  LEU   A C   1 
ATOM   1951 O O   . LEU   A 1 284 ? -24.55796 -20.48320 -38.56133 1.000 17.99632 ? 266  LEU   A O   1 
ATOM   1952 C CB  . LEU   A 1 284 ? -21.54732 -20.89931 -40.04461 1.000 16.15329 ? 266  LEU   A CB  1 
ATOM   1953 C CG  . LEU   A 1 284 ? -21.83427 -22.31162 -40.56039 1.000 30.02099 ? 266  LEU   A CG  1 
ATOM   1954 C CD1 . LEU   A 1 284 ? -21.39198 -23.33177 -39.52437 1.000 31.18664 ? 266  LEU   A CD1 1 
ATOM   1955 C CD2 . LEU   A 1 284 ? -23.29336 -22.53825 -40.97392 1.000 23.34592 ? 266  LEU   A CD2 1 
ATOM   1956 N N   . LEU   A 1 285 ? -22.74610 -19.88528 -37.36273 1.000 18.19752 ? 267  LEU   A N   1 
ATOM   1957 C CA  . LEU   A 1 285 ? -23.42791 -20.08281 -36.08717 1.000 14.41954 ? 267  LEU   A CA  1 
ATOM   1958 C C   . LEU   A 1 285 ? -24.56639 -19.08344 -35.92011 1.000 14.07477 ? 267  LEU   A C   1 
ATOM   1959 O O   . LEU   A 1 285 ? -25.63668 -19.42373 -35.40408 1.000 17.57918 ? 267  LEU   A O   1 
ATOM   1960 C CB  . LEU   A 1 285 ? -22.42321 -19.93512 -34.94634 1.000 14.26306 ? 267  LEU   A CB  1 
ATOM   1961 C CG  . LEU   A 1 285 ? -21.37839 -21.04704 -34.81105 1.000 15.26623 ? 267  LEU   A CG  1 
ATOM   1962 C CD1 . LEU   A 1 285 ? -20.09539 -20.49566 -34.18186 1.000 15.64222 ? 267  LEU   A CD1 1 
ATOM   1963 C CD2 . LEU   A 1 285 ? -21.93517 -22.18737 -33.98272 1.000 17.58230 ? 267  LEU   A CD2 1 
ATOM   1964 N N   . TYR   A 1 286 ? -24.33941 -17.84057 -36.34134 1.000 18.30620 ? 268  TYR   A N   1 
ATOM   1965 C CA  . TYR   A 1 286 ? -25.37740 -16.81589 -36.27101 1.000 16.11788 ? 268  TYR   A CA  1 
ATOM   1966 C C   . TYR   A 1 286 ? -26.62512 -17.25122 -37.02719 1.000 17.62713 ? 268  TYR   A C   1 
ATOM   1967 O O   . TYR   A 1 286 ? -27.74401 -17.19479 -36.49856 1.000 16.96002 ? 268  TYR   A O   1 
ATOM   1968 C CB  . TYR   A 1 286 ? -24.83781 -15.51967 -36.85510 1.000 15.61580 ? 268  TYR   A CB  1 
ATOM   1969 C CG  . TYR   A 1 286 ? -25.82966 -14.37704 -36.86931 1.000 19.23561 ? 268  TYR   A CG  1 
ATOM   1970 C CD1 . TYR   A 1 286 ? -26.73863 -14.22748 -37.91135 1.000 25.55681 ? 268  TYR   A CD1 1 
ATOM   1971 C CD2 . TYR   A 1 286 ? -25.83400 -13.43076 -35.85264 1.000 24.03399 ? 268  TYR   A CD2 1 
ATOM   1972 C CE1 . TYR   A 1 286 ? -27.64238 -13.17962 -37.92885 1.000 24.30225 ? 268  TYR   A CE1 1 
ATOM   1973 C CE2 . TYR   A 1 286 ? -26.72909 -12.36953 -35.86566 1.000 25.26028 ? 268  TYR   A CE2 1 
ATOM   1974 C CZ  . TYR   A 1 286 ? -27.63187 -12.25264 -36.90591 1.000 25.87895 ? 268  TYR   A CZ  1 
ATOM   1975 O OH  . TYR   A 1 286 ? -28.52661 -11.20381 -36.92386 1.000 26.71368 ? 268  TYR   A OH  1 
ATOM   1976 N N   . ASP   A 1 287 ? -26.44212 -17.68784 -38.27739 1.000 17.55419 ? 269  ASP   A N   1 
ATOM   1977 C CA  . ASP   A 1 287 ? -27.57170 -18.05434 -39.12692 1.000 24.60345 ? 269  ASP   A CA  1 
ATOM   1978 C C   . ASP   A 1 287 ? -28.35045 -19.22914 -38.56476 1.000 25.66454 ? 269  ASP   A C   1 
ATOM   1979 O O   . ASP   A 1 287 ? -29.55281 -19.35523 -38.82290 1.000 27.16842 ? 269  ASP   A O   1 
ATOM   1980 C CB  . ASP   A 1 287 ? -27.08104 -18.37650 -40.53586 1.000 22.45668 ? 269  ASP   A CB  1 
ATOM   1981 C CG  . ASP   A 1 287 ? -26.62699 -17.14949 -41.28616 1.000 25.52110 ? 269  ASP   A CG  1 
ATOM   1982 O OD1 . ASP   A 1 287 ? -27.00918 -16.02880 -40.88376 1.000 26.54907 ? 269  ASP   A OD1 1 
ATOM   1983 O OD2 . ASP   A 1 287 ? -25.88603 -17.30247 -42.28195 1.000 28.16775 ? 269  ASP   A OD2 1 
ATOM   1984 N N   . LEU   A 1 288 ? -27.69375 -20.10118 -37.80713 1.000 22.29826 ? 270  LEU   A N   1 
ATOM   1985 C CA  . LEU   A 1 288 ? -28.36294 -21.23633 -37.19017 1.000 20.65265 ? 270  LEU   A CA  1 
ATOM   1986 C C   . LEU   A 1 288 ? -29.00332 -20.88714 -35.85150 1.000 21.85114 ? 270  LEU   A C   1 
ATOM   1987 O O   . LEU   A 1 288 ? -29.60363 -21.76158 -35.21597 1.000 20.04317 ? 270  LEU   A O   1 
ATOM   1988 C CB  . LEU   A 1 288 ? -27.36874 -22.39412 -37.02466 1.000 18.63088 ? 270  LEU   A CB  1 
ATOM   1989 C CG  . LEU   A 1 288 ? -26.92135 -23.08577 -38.31517 1.000 23.87122 ? 270  LEU   A CG  1 
ATOM   1990 C CD1 . LEU   A 1 288 ? -25.67389 -23.92698 -38.07246 1.000 22.63393 ? 270  LEU   A CD1 1 
ATOM   1991 C CD2 . LEU   A 1 288 ? -28.04546 -23.95329 -38.87128 1.000 24.22587 ? 270  LEU   A CD2 1 
ATOM   1992 N N   . GLY   A 1 289 ? -28.89734 -19.63476 -35.41122 1.000 23.10833 ? 271  GLY   A N   1 
ATOM   1993 C CA  . GLY   A 1 289 ? -29.47614 -19.23005 -34.14691 1.000 21.69821 ? 271  GLY   A CA  1 
ATOM   1994 C C   . GLY   A 1 289 ? -28.65418 -19.55794 -32.91990 1.000 18.16199 ? 271  GLY   A C   1 
ATOM   1995 O O   . GLY   A 1 289 ? -29.18294 -19.50095 -31.80471 1.000 18.80705 ? 271  GLY   A O   1 
ATOM   1996 N N   . HIS   A 1 290 ? -27.37886 -19.89147 -33.07239 1.000 21.52397 ? 272  HIS   A N   1 
ATOM   1997 C CA  . HIS   A 1 290 ? -26.59885 -20.33269 -31.92488 1.000 16.89027 ? 272  HIS   A CA  1 
ATOM   1998 C C   . HIS   A 1 290 ? -25.81820 -19.21002 -31.25120 1.000 13.74457 ? 272  HIS   A C   1 
ATOM   1999 O O   . HIS   A 1 290 ? -25.07095 -19.48336 -30.30819 1.000 20.20110 ? 272  HIS   A O   1 
ATOM   2000 C CB  . HIS   A 1 290 ? -25.65424 -21.47198 -32.34164 1.000 16.39191 ? 272  HIS   A CB  1 
ATOM   2001 C CG  . HIS   A 1 290 ? -26.37378 -22.64908 -32.92459 1.000 22.25515 ? 272  HIS   A CG  1 
ATOM   2002 N ND1 . HIS   A 1 290 ? -27.40999 -23.28111 -32.27135 1.000 24.12373 ? 272  HIS   A ND1 1 
ATOM   2003 C CD2 . HIS   A 1 290 ? -26.22101 -23.29762 -34.10272 1.000 22.69277 ? 272  HIS   A CD2 1 
ATOM   2004 C CE1 . HIS   A 1 290 ? -27.86535 -24.26831 -33.02207 1.000 22.75741 ? 272  HIS   A CE1 1 
ATOM   2005 N NE2 . HIS   A 1 290 ? -27.16105 -24.30021 -34.13918 1.000 22.94741 ? 272  HIS   A NE2 1 
ATOM   2006 N N   . LEU   A 1 291 ? -25.96721 -17.96264 -31.69630 1.000 16.83335 ? 273  LEU   A N   1 
ATOM   2007 C CA  . LEU   A 1 291 ? -25.40822 -16.82573 -30.97339 1.000 17.87915 ? 273  LEU   A CA  1 
ATOM   2008 C C   . LEU   A 1 291 ? -26.47281 -16.03546 -30.22618 1.000 17.53364 ? 273  LEU   A C   1 
ATOM   2009 O O   . LEU   A 1 291 ? -26.14740 -15.02147 -29.60489 1.000 17.61590 ? 273  LEU   A O   1 
ATOM   2010 C CB  . LEU   A 1 291 ? -24.64697 -15.90262 -31.92877 1.000 14.26554 ? 273  LEU   A CB  1 
ATOM   2011 C CG  . LEU   A 1 291 ? -23.54229 -16.55870 -32.76969 1.000 13.16042 ? 273  LEU   A CG  1 
ATOM   2012 C CD1 . LEU   A 1 291 ? -22.71623 -15.49774 -33.47893 1.000 13.74492 ? 273  LEU   A CD1 1 
ATOM   2013 C CD2 . LEU   A 1 291 ? -22.64783 -17.50312 -31.92281 1.000 10.79844 ? 273  LEU   A CD2 1 
ATOM   2014 N N   . GLU   A 1 292 ? -27.72682 -16.50001 -30.26514 1.000 16.15509 ? 274  GLU   A N   1 
ATOM   2015 C CA  . GLU   A 1 292 ? -28.85606 -15.78304 -29.66955 1.000 17.24733 ? 274  GLU   A CA  1 
ATOM   2016 C C   . GLU   A 1 292 ? -28.66430 -15.52730 -28.17355 1.000 19.07972 ? 274  GLU   A C   1 
ATOM   2017 O O   . GLU   A 1 292 ? -29.06793 -14.47451 -27.66419 1.000 17.25787 ? 274  GLU   A O   1 
ATOM   2018 C CB  . GLU   A 1 292 ? -30.13809 -16.58026 -29.91961 1.000 26.72644 ? 274  GLU   A CB  1 
ATOM   2019 C CG  . GLU   A 1 292 ? -31.35983 -16.15518 -29.11000 1.000 27.94975 ? 274  GLU   A CG  1 
ATOM   2020 C CD  . GLU   A 1 292 ? -31.94527 -14.83523 -29.56543 1.000 32.23680 ? 274  GLU   A CD  1 
ATOM   2021 O OE1 . GLU   A 1 292 ? -31.56404 -14.35810 -30.65849 1.000 27.13380 ? 274  GLU   A OE1 1 
ATOM   2022 O OE2 . GLU   A 1 292 ? -32.80375 -14.28645 -28.83287 1.000 29.92479 ? 274  GLU   A OE2 1 
ATOM   2023 N N   . ARG   A 1 293 ? -28.07215 -16.48028 -27.44627 1.000 12.51164 ? 275  ARG   A N   1 
ATOM   2024 C CA  . ARG   A 1 293 ? -27.82094 -16.33638 -26.01589 1.000 17.27626 ? 275  ARG   A CA  1 
ATOM   2025 C C   . ARG   A 1 293 ? -26.33728 -16.14584 -25.70091 1.000 14.52141 ? 275  ARG   A C   1 
ATOM   2026 O O   . ARG   A 1 293 ? -25.87444 -16.49306 -24.61148 1.000 15.09310 ? 275  ARG   A O   1 
ATOM   2027 C CB  . ARG   A 1 293 ? -28.37555 -17.53594 -25.25063 1.000 18.86874 ? 275  ARG   A CB  1 
ATOM   2028 C CG  . ARG   A 1 293 ? -29.73172 -17.99263 -25.75465 1.000 23.14500 ? 275  ARG   A CG  1 
ATOM   2029 C CD  . ARG   A 1 293 ? -30.31386 -19.11437 -24.89252 1.000 25.74064 ? 275  ARG   A CD  1 
ATOM   2030 N NE  . ARG   A 1 293 ? -31.69446 -19.48215 -25.22000 1.000 43.75561 ? 275  ARG   A NE  1 
ATOM   2031 C CZ  . ARG   A 1 293 ? -32.22588 -19.59803 -26.43680 1.000 55.23652 ? 275  ARG   A CZ  1 
ATOM   2032 N NH1 . ARG   A 1 293 ? -31.48805 -19.54591 -27.53907 1.000 38.92755 ? 275  ARG   A NH1 1 
ATOM   2033 N NH2 . ARG   A 1 293 ? -33.53453 -19.81177 -26.55142 1.000 49.16958 ? 275  ARG   A NH2 1 
ATOM   2034 N N   . TYR   A 1 294 ? -25.58237 -15.57997 -26.63012 1.000 15.14914 ? 276  TYR   A N   1 
ATOM   2035 C CA  . TYR   A 1 294 ? -24.12930 -15.46981 -26.49897 1.000 12.79925 ? 276  TYR   A CA  1 
ATOM   2036 C C   . TYR   A 1 294 ? -23.70081 -14.04110 -26.80582 1.000 11.47387 ? 276  TYR   A C   1 
ATOM   2037 O O   . TYR   A 1 294 ? -23.16750 -13.76022 -27.88939 1.000 12.33652 ? 276  TYR   A O   1 
ATOM   2038 C CB  . TYR   A 1 294 ? -23.44337 -16.47635 -27.42252 1.000 12.62299 ? 276  TYR   A CB  1 
ATOM   2039 C CG  . TYR   A 1 294 ? -22.05843 -16.89806 -27.01844 1.000 12.53399 ? 276  TYR   A CG  1 
ATOM   2040 C CD1 . TYR   A 1 294 ? -21.20667 -16.03161 -26.34033 1.000 11.85533 ? 276  TYR   A CD1 1 
ATOM   2041 C CD2 . TYR   A 1 294 ? -21.58072 -18.15926 -27.35801 1.000 13.57934 ? 276  TYR   A CD2 1 
ATOM   2042 C CE1 . TYR   A 1 294 ? -19.91092 -16.42251 -25.98238 1.000 15.91425 ? 276  TYR   A CE1 1 
ATOM   2043 C CE2 . TYR   A 1 294 ? -20.29554 -18.55207 -27.01344 1.000 16.31613 ? 276  TYR   A CE2 1 
ATOM   2044 C CZ  . TYR   A 1 294 ? -19.46231 -17.67982 -26.33122 1.000 14.43514 ? 276  TYR   A CZ  1 
ATOM   2045 O OH  . TYR   A 1 294 ? -18.18341 -18.07863 -25.98357 1.000 12.70383 ? 276  TYR   A OH  1 
ATOM   2046 N N   . PRO   A 1 295 ? -23.90220 -13.10688 -25.86188 1.000 12.08834 ? 277  PRO   A N   1 
ATOM   2047 C CA  . PRO   A 1 295 ? -23.55550 -11.69976 -26.13754 1.000 11.07408 ? 277  PRO   A CA  1 
ATOM   2048 C C   . PRO   A 1 295 ? -22.11706 -11.45151 -26.59353 1.000 17.42385 ? 277  PRO   A C   1 
ATOM   2049 O O   . PRO   A 1 295 ? -21.93891 -10.67939 -27.53979 1.000 13.41394 ? 277  PRO   A O   1 
ATOM   2050 C CB  . PRO   A 1 295 ? -23.84935 -11.00674 -24.79667 1.000 10.51835 ? 277  PRO   A CB  1 
ATOM   2051 C CG  . PRO   A 1 295 ? -24.95125 -11.81885 -24.20938 1.000 13.53957 ? 277  PRO   A CG  1 
ATOM   2052 C CD  . PRO   A 1 295 ? -24.58799 -13.25113 -24.56123 1.000 13.98889 ? 277  PRO   A CD  1 
ATOM   2053 N N   . MET   A 1 296 ? -21.08592 -12.04179 -25.96535 1.000 9.60754  ? 278  MET   A N   1 
ATOM   2054 C CA  . MET   A 1 296 ? -19.72313 -11.70431 -26.39214 1.000 9.83256  ? 278  MET   A CA  1 
ATOM   2055 C C   . MET   A 1 296 ? -19.41775 -12.23137 -27.78131 1.000 11.13767 ? 278  MET   A C   1 
ATOM   2056 O O   . MET   A 1 296 ? -18.60183 -11.63775 -28.49249 1.000 11.47452 ? 278  MET   A O   1 
ATOM   2057 C CB  . MET   A 1 296 ? -18.63114 -12.20943 -25.43747 1.000 12.14892 ? 278  MET   A CB  1 
ATOM   2058 C CG  . MET   A 1 296 ? -18.66657 -11.68291 -24.02351 1.000 10.76087 ? 278  MET   A CG  1 
ATOM   2059 S SD  . MET   A 1 296 ? -17.51521 -12.52770 -22.90313 1.000 14.01631 ? 278  MET   A SD  1 
ATOM   2060 C CE  . MET   A 1 296 ? -18.33078 -14.06120 -22.50455 1.000 7.14574  ? 278  MET   A CE  1 
ATOM   2061 N N   . ALA   A 1 297 ? -20.03710 -13.34207 -28.17740 1.000 12.05336 ? 279  ALA   A N   1 
ATOM   2062 C CA  . ALA   A 1 297 ? -19.88014 -13.81140 -29.54859 1.000 14.37205 ? 279  ALA   A CA  1 
ATOM   2063 C C   . ALA   A 1 297 ? -20.46425 -12.81467 -30.54943 1.000 10.88300 ? 279  ALA   A C   1 
ATOM   2064 O O   . ALA   A 1 297 ? -19.90011 -12.60382 -31.62777 1.000 8.72056  ? 279  ALA   A O   1 
ATOM   2065 C CB  . ALA   A 1 297 ? -20.53759 -15.18316 -29.70662 1.000 12.30783 ? 279  ALA   A CB  1 
ATOM   2066 N N   . LEU   A 1 298 ? -21.61230 -12.20765 -30.22119 1.000 12.27326 ? 280  LEU   A N   1 
ATOM   2067 C CA  . LEU   A 1 298 ? -22.18903 -11.18246 -31.08772 1.000 10.87096 ? 280  LEU   A CA  1 
ATOM   2068 C C   . LEU   A 1 298 ? -21.30527 -9.93653  -31.15344 1.000 9.74057  ? 280  LEU   A C   1 
ATOM   2069 O O   . LEU   A 1 298 ? -21.18877 -9.31052  -32.21206 1.000 13.56321 ? 280  LEU   A O   1 
ATOM   2070 C CB  . LEU   A 1 298 ? -23.59545 -10.81724 -30.59583 1.000 12.62023 ? 280  LEU   A CB  1 
ATOM   2071 C CG  . LEU   A 1 298 ? -24.60962 -11.94422 -30.77100 1.000 11.02211 ? 280  LEU   A CG  1 
ATOM   2072 C CD1 . LEU   A 1 298 ? -25.82862 -11.76649 -29.85013 1.000 14.72471 ? 280  LEU   A CD1 1 
ATOM   2073 C CD2 . LEU   A 1 298 ? -25.02360 -12.07228 -32.24468 1.000 16.89938 ? 280  LEU   A CD2 1 
ATOM   2074 N N   . GLY   A 1 299 ? -20.67016 -9.55579  -30.04153 1.000 11.56669 ? 281  GLY   A N   1 
ATOM   2075 C CA  . GLY   A 1 299 ? -19.74487 -8.42564  -30.09001 1.000 7.13584  ? 281  GLY   A CA  1 
ATOM   2076 C C   . GLY   A 1 299 ? -18.48995 -8.73818  -30.88572 1.000 15.20825 ? 281  GLY   A C   1 
ATOM   2077 O O   . GLY   A 1 299 ? -17.97624 -7.88393  -31.61888 1.000 11.33392 ? 281  GLY   A O   1 
ATOM   2078 N N   . ASN   A 1 300 ? -17.96892 -9.96340  -30.72490 1.000 10.80570 ? 282  ASN   A N   1 
ATOM   2079 C CA  . ASN   A 1 300 ? -16.86980 -10.46721 -31.53801 1.000 13.82905 ? 282  ASN   A CA  1 
ATOM   2080 C C   . ASN   A 1 300 ? -17.20190 -10.35494 -33.01960 1.000 14.41889 ? 282  ASN   A C   1 
ATOM   2081 O O   . ASN   A 1 300 ? -16.38673 -9.88683  -33.81854 1.000 12.90739 ? 282  ASN   A O   1 
ATOM   2082 C CB  . ASN   A 1 300 ? -16.60049 -11.92851 -31.15084 1.000 12.29637 ? 282  ASN   A CB  1 
ATOM   2083 C CG  . ASN   A 1 300 ? -15.26136 -12.46561 -31.65634 1.000 23.43574 ? 282  ASN   A CG  1 
ATOM   2084 O OD1 . ASN   A 1 300 ? -14.73178 -13.42321 -31.08834 1.000 21.35772 ? 282  ASN   A OD1 1 
ATOM   2085 N ND2 . ASN   A 1 300 ? -14.72208 -11.87764 -32.71934 1.000 18.51150 ? 282  ASN   A ND2 1 
ATOM   2086 N N   . LEU   A 1 301 ? -18.39526 -10.80425 -33.40718 1.000 13.06273 ? 283  LEU   A N   1 
ATOM   2087 C CA  . LEU   A 1 301 ? -18.76418 -10.74614 -34.81977 1.000 14.70163 ? 283  LEU   A CA  1 
ATOM   2088 C C   . LEU   A 1 301 ? -18.87800 -9.30409  -35.29885 1.000 16.59310 ? 283  LEU   A C   1 
ATOM   2089 O O   . LEU   A 1 301 ? -18.46851 -8.98062  -36.41817 1.000 18.26883 ? 283  LEU   A O   1 
ATOM   2090 C CB  . LEU   A 1 301 ? -20.07234 -11.48954 -35.04958 1.000 14.08216 ? 283  LEU   A CB  1 
ATOM   2091 C CG  . LEU   A 1 301 ? -20.59886 -11.57136 -36.48739 1.000 17.31374 ? 283  LEU   A CG  1 
ATOM   2092 C CD1 . LEU   A 1 301 ? -19.57440 -12.23171 -37.41400 1.000 19.27703 ? 283  LEU   A CD1 1 
ATOM   2093 C CD2 . LEU   A 1 301 ? -21.91886 -12.32699 -36.50091 1.000 18.71016 ? 283  LEU   A CD2 1 
ATOM   2094 N N   . ALA   A 1 302 ? -19.43218 -8.42382  -34.46596 1.000 14.76521 ? 284  ALA   A N   1 
ATOM   2095 C CA  . ALA   A 1 302 ? -19.52313 -7.01528  -34.84151 1.000 16.26579 ? 284  ALA   A CA  1 
ATOM   2096 C C   . ALA   A 1 302 ? -18.13987 -6.39580  -35.00548 1.000 14.64677 ? 284  ALA   A C   1 
ATOM   2097 O O   . ALA   A 1 302 ? -17.91031 -5.60881  -35.93404 1.000 16.72460 ? 284  ALA   A O   1 
ATOM   2098 C CB  . ALA   A 1 302 ? -20.33761 -6.25467  -33.79770 1.000 12.07061 ? 284  ALA   A CB  1 
ATOM   2099 N N   . ASP   A 1 303 ? -17.20586 -6.73383  -34.10645 1.000 14.72707 ? 285  ASP   A N   1 
ATOM   2100 C CA  . ASP   A 1 303 ? -15.83178 -6.24585  -34.22209 1.000 14.41505 ? 285  ASP   A CA  1 
ATOM   2101 C C   . ASP   A 1 303 ? -15.19403 -6.67659  -35.53710 1.000 20.11631 ? 285  ASP   A C   1 
ATOM   2102 O O   . ASP   A 1 303 ? -14.44906 -5.90617  -36.15798 1.000 22.45573 ? 285  ASP   A O   1 
ATOM   2103 C CB  . ASP   A 1 303 ? -14.97557 -6.75568  -33.05872 1.000 13.29782 ? 285  ASP   A CB  1 
ATOM   2104 C CG  . ASP   A 1 303 ? -15.15051 -5.94064  -31.78467 1.000 19.41413 ? 285  ASP   A CG  1 
ATOM   2105 O OD1 . ASP   A 1 303 ? -15.93979 -4.96524  -31.77467 1.000 15.83161 ? 285  ASP   A OD1 1 
ATOM   2106 O OD2 . ASP   A 1 303 ? -14.47968 -6.28257  -30.78292 1.000 18.11749 ? 285  ASP   A OD2 1 
ATOM   2107 N N   . LEU   A 1 304 ? -15.44404 -7.91677  -35.95528 1.000 13.78876 ? 286  LEU   A N   1 
ATOM   2108 C CA  . LEU   A 1 304 ? -14.89023 -8.40722  -37.21510 1.000 18.03285 ? 286  LEU   A CA  1 
ATOM   2109 C C   . LEU   A 1 304 ? -15.51538 -7.69168  -38.40592 1.000 18.35670 ? 286  LEU   A C   1 
ATOM   2110 O O   . LEU   A 1 304 ? -14.81686 -7.35378  -39.37003 1.000 22.26375 ? 286  LEU   A O   1 
ATOM   2111 C CB  . LEU   A 1 304 ? -15.11037 -9.91384  -37.32447 1.000 13.89358 ? 286  LEU   A CB  1 
ATOM   2112 C CG  . LEU   A 1 304 ? -14.28298 -10.78083 -36.37605 1.000 16.45980 ? 286  LEU   A CG  1 
ATOM   2113 C CD1 . LEU   A 1 304 ? -14.81475 -12.20709 -36.34090 1.000 13.14174 ? 286  LEU   A CD1 1 
ATOM   2114 C CD2 . LEU   A 1 304 ? -12.81532 -10.75349 -36.77762 1.000 16.36253 ? 286  LEU   A CD2 1 
ATOM   2115 N N   . GLU   A 1 305 ? -16.82820 -7.43747  -38.34331 1.000 16.31319 ? 287  GLU   A N   1 
ATOM   2116 C CA  . GLU   A 1 305 ? -17.51926 -6.72530  -39.41627 1.000 18.50923 ? 287  GLU   A CA  1 
ATOM   2117 C C   . GLU   A 1 305 ? -17.06874 -5.27576  -39.50741 1.000 19.31521 ? 287  GLU   A C   1 
ATOM   2118 O O   . GLU   A 1 305 ? -17.11222 -4.68714  -40.58898 1.000 20.58035 ? 287  GLU   A O   1 
ATOM   2119 C CB  . GLU   A 1 305 ? -19.03375 -6.79374  -39.20101 1.000 18.54103 ? 287  GLU   A CB  1 
ATOM   2120 C CG  . GLU   A 1 305 ? -19.65308 -8.15088  -39.53092 1.000 14.09945 ? 287  GLU   A CG  1 
ATOM   2121 C CD  . GLU   A 1 305 ? -19.53710 -8.51808  -41.00385 1.000 27.08347 ? 287  GLU   A CD  1 
ATOM   2122 O OE1 . GLU   A 1 305 ? -19.87423 -7.66705  -41.85751 1.000 19.22490 ? 287  GLU   A OE1 1 
ATOM   2123 O OE2 . GLU   A 1 305 ? -19.10066 -9.65202  -41.30749 1.000 20.27554 ? 287  GLU   A OE2 1 
ATOM   2124 N N   . GLU   A 1 306 ? -16.65129 -4.68324  -38.38525 1.000 18.84898 ? 288  GLU   A N   1 
ATOM   2125 C CA  . GLU   A 1 306 ? -16.10713 -3.33063  -38.41483 1.000 16.11537 ? 288  GLU   A CA  1 
ATOM   2126 C C   . GLU   A 1 306 ? -14.85026 -3.26798  -39.27123 1.000 24.40678 ? 288  GLU   A C   1 
ATOM   2127 O O   . GLU   A 1 306 ? -14.64116 -2.30314  -40.01541 1.000 20.08082 ? 288  GLU   A O   1 
ATOM   2128 C CB  . GLU   A 1 306 ? -15.79200 -2.85695  -36.99673 1.000 21.33445 ? 288  GLU   A CB  1 
ATOM   2129 C CG  . GLU   A 1 306 ? -15.16034 -1.46267  -36.92565 1.000 18.53700 ? 288  GLU   A CG  1 
ATOM   2130 C CD  . GLU   A 1 306 ? -14.74959 -1.07209  -35.50793 1.000 24.41430 ? 288  GLU   A CD  1 
ATOM   2131 O OE1 . GLU   A 1 306 ? -14.86657 -1.91132  -34.59039 1.000 31.65317 ? 288  GLU   A OE1 1 
ATOM   2132 O OE2 . GLU   A 1 306 ? -14.31058 0.07774   -35.30431 1.000 22.55779 ? 288  GLU   A OE2 1 
ATOM   2133 N N   . LEU   A 1 307 ? -13.99295 -4.28573  -39.16866 1.000 26.76431 ? 289  LEU   A N   1 
ATOM   2134 C CA  . LEU   A 1 307 ? -12.74518 -4.29383  -39.92235 1.000 27.07971 ? 289  LEU   A CA  1 
ATOM   2135 C C   . LEU   A 1 307 ? -12.94881 -4.80155  -41.34670 1.000 24.16665 ? 289  LEU   A C   1 
ATOM   2136 O O   . LEU   A 1 307 ? -12.32613 -4.28982  -42.28111 1.000 28.40740 ? 289  LEU   A O   1 
ATOM   2137 C CB  . LEU   A 1 307 ? -11.70881 -5.14905  -39.19256 1.000 35.89220 ? 289  LEU   A CB  1 
ATOM   2138 C CG  . LEU   A 1 307 ? -11.28871 -4.67332  -37.80026 1.000 45.68088 ? 289  LEU   A CG  1 
ATOM   2139 C CD1 . LEU   A 1 307 ? -9.93279  -5.24922  -37.43087 1.000 55.81809 ? 289  LEU   A CD1 1 
ATOM   2140 C CD2 . LEU   A 1 307 ? -11.25642 -3.14115  -37.72114 1.000 40.28152 ? 289  LEU   A CD2 1 
ATOM   2141 N N   . GLU   A 1 308 ? -13.81263 -5.79788  -41.53350 1.000 22.22369 ? 290  GLU   A N   1 
ATOM   2142 C CA  . GLU   A 1 308 ? -13.99025 -6.46376  -42.82799 1.000 26.26688 ? 290  GLU   A CA  1 
ATOM   2143 C C   . GLU   A 1 308 ? -15.47107 -6.68956  -43.08480 1.000 21.26915 ? 290  GLU   A C   1 
ATOM   2144 O O   . GLU   A 1 308 ? -15.97375 -7.81389  -42.96598 1.000 20.15574 ? 290  GLU   A O   1 
ATOM   2145 C CB  . GLU   A 1 308 ? -13.23898 -7.80206  -42.87158 1.000 29.00649 ? 290  GLU   A CB  1 
ATOM   2146 C CG  . GLU   A 1 308 ? -11.75689 -7.74738  -42.51988 1.000 31.29015 ? 290  GLU   A CG  1 
ATOM   2147 C CD  . GLU   A 1 308 ? -10.90464 -7.21314  -43.65993 1.000 45.16727 ? 290  GLU   A CD  1 
ATOM   2148 O OE1 . GLU   A 1 308 ? -11.46234 -6.95987  -44.75089 1.000 41.23264 ? 290  GLU   A OE1 1 
ATOM   2149 O OE2 . GLU   A 1 308 ? -9.67727  -7.05590  -43.46748 1.000 41.25655 ? 290  GLU   A OE2 1 
ATOM   2150 N N   . PRO   A 1 309 ? -16.20661 -5.64125  -43.45856 1.000 19.76053 ? 291  PRO   A N   1 
ATOM   2151 C CA  . PRO   A 1 309 ? -17.66059 -5.78926  -43.61937 1.000 23.60093 ? 291  PRO   A CA  1 
ATOM   2152 C C   . PRO   A 1 309 ? -18.01330 -6.80873  -44.69573 1.000 27.22749 ? 291  PRO   A C   1 
ATOM   2153 O O   . PRO   A 1 309 ? -17.45405 -6.80062  -45.79233 1.000 29.12622 ? 291  PRO   A O   1 
ATOM   2154 C CB  . PRO   A 1 309 ? -18.12192 -4.37520  -43.99773 1.000 25.08963 ? 291  PRO   A CB  1 
ATOM   2155 C CG  . PRO   A 1 309 ? -16.89735 -3.68898  -44.52680 1.000 23.85910 ? 291  PRO   A CG  1 
ATOM   2156 C CD  . PRO   A 1 309 ? -15.75269 -4.26732  -43.73547 1.000 23.91034 ? 291  PRO   A CD  1 
ATOM   2157 N N   . THR   A 1 310 ? -18.93840 -7.70573  -44.36159 1.000 28.12071 ? 292  THR   A N   1 
ATOM   2158 C CA  . THR   A 1 310 ? -19.41984 -8.70064  -45.30886 1.000 24.87431 ? 292  THR   A CA  1 
ATOM   2159 C C   . THR   A 1 310 ? -20.64517 -8.15582  -46.03633 1.000 35.15621 ? 292  THR   A C   1 
ATOM   2160 O O   . THR   A 1 310 ? -21.65030 -7.84053  -45.38228 1.000 27.75679 ? 292  THR   A O   1 
ATOM   2161 C CB  . THR   A 1 310 ? -19.76429 -10.00071 -44.59762 1.000 26.01090 ? 292  THR   A CB  1 
ATOM   2162 O OG1 . THR   A 1 310 ? -18.63121 -10.44847 -43.83512 1.000 26.34468 ? 292  THR   A OG1 1 
ATOM   2163 C CG2 . THR   A 1 310 ? -20.15316 -11.08018 -45.60497 1.000 27.89656 ? 292  THR   A CG2 1 
ATOM   2164 N N   . PRO   A 1 311 ? -20.60801 -8.01316  -47.36198 1.000 33.55641 ? 293  PRO   A N   1 
ATOM   2165 C CA  . PRO   A 1 311 ? -21.76514 -7.44913  -48.07338 1.000 24.84516 ? 293  PRO   A CA  1 
ATOM   2166 C C   . PRO   A 1 311 ? -23.02175 -8.27602  -47.84578 1.000 25.15504 ? 293  PRO   A C   1 
ATOM   2167 O O   . PRO   A 1 311 ? -22.98166 -9.50753  -47.81534 1.000 30.20573 ? 293  PRO   A O   1 
ATOM   2168 C CB  . PRO   A 1 311 ? -21.33837 -7.46542  -49.54885 1.000 37.90617 ? 293  PRO   A CB  1 
ATOM   2169 C CG  . PRO   A 1 311 ? -19.91830 -7.87750  -49.59396 1.000 35.25187 ? 293  PRO   A CG  1 
ATOM   2170 C CD  . PRO   A 1 311 ? -19.44660 -8.26863  -48.23202 1.000 31.96696 ? 293  PRO   A CD  1 
ATOM   2171 N N   . GLY   A 1 312 ? -24.14538 -7.58002  -47.67241 1.000 26.01733 ? 294  GLY   A N   1 
ATOM   2172 C CA  . GLY   A 1 312 ? -25.41376 -8.22777  -47.40757 1.000 28.62362 ? 294  GLY   A CA  1 
ATOM   2173 C C   . GLY   A 1 312 ? -25.70007 -8.52349  -45.95035 1.000 35.23167 ? 294  GLY   A C   1 
ATOM   2174 O O   . GLY   A 1 312 ? -26.79996 -8.99740  -45.63695 1.000 35.17350 ? 294  GLY   A O   1 
ATOM   2175 N N   . ARG   A 1 313 ? -24.72789 -8.24159  -45.01993 1.000 31.05768 ? 295  ARG   A N   1 
ATOM   2176 C CA  . ARG   A 1 313 ? -24.86851 -8.55076  -43.60636 1.000 21.58116 ? 295  ARG   A CA  1 
ATOM   2177 C C   . ARG   A 1 313 ? -25.21259 -7.29816  -42.80173 1.000 20.91534 ? 295  ARG   A C   1 
ATOM   2178 O O   . ARG   A 1 313 ? -24.88534 -6.18249  -43.21528 1.000 19.18903 ? 295  ARG   A O   1 
ATOM   2179 C CB  . ARG   A 1 313 ? -23.56444 -9.15879  -43.07504 1.000 24.72820 ? 295  ARG   A CB  1 
ATOM   2180 C CG  . ARG   A 1 313 ? -23.33197 -10.59293 -43.55788 1.000 22.19804 ? 295  ARG   A CG  1 
ATOM   2181 C CD  . ARG   A 1 313 ? -24.44158 -11.52730 -43.08488 1.000 27.99278 ? 295  ARG   A CD  1 
ATOM   2182 N NE  . ARG   A 1 313 ? -24.10999 -12.92107 -43.35445 1.000 17.06891 ? 295  ARG   A NE  1 
ATOM   2183 C CZ  . ARG   A 1 313 ? -24.80390 -13.96511 -42.92579 1.000 19.10355 ? 295  ARG   A CZ  1 
ATOM   2184 N NH1 . ARG   A 1 313 ? -25.91708 -13.81753 -42.22443 1.000 22.11788 ? 295  ARG   A NH1 1 
ATOM   2185 N NH2 . ARG   A 1 313 ? -24.36281 -15.19374 -43.19972 1.000 22.96520 ? 295  ARG   A NH2 1 
ATOM   2186 N N   . PRO   A 1 314 ? -25.86432 -7.45157  -41.64555 1.000 20.59639 ? 296  PRO   A N   1 
ATOM   2187 C CA  . PRO   A 1 314 ? -26.13085 -6.28678  -40.78609 1.000 23.37454 ? 296  PRO   A CA  1 
ATOM   2188 C C   . PRO   A 1 314 ? -24.83705 -5.55977  -40.44705 1.000 25.24776 ? 296  PRO   A C   1 
ATOM   2189 O O   . PRO   A 1 314 ? -23.76217 -6.16503  -40.38558 1.000 23.97794 ? 296  PRO   A O   1 
ATOM   2190 C CB  . PRO   A 1 314 ? -26.77594 -6.89698  -39.53586 1.000 22.55175 ? 296  PRO   A CB  1 
ATOM   2191 C CG  . PRO   A 1 314 ? -27.15841 -8.28785  -39.89998 1.000 26.98064 ? 296  PRO   A CG  1 
ATOM   2192 C CD  . PRO   A 1 314 ? -26.33329 -8.71945  -41.05863 1.000 17.14944 ? 296  PRO   A CD  1 
ATOM   2193 N N   . ASP   A 1 315 ? -24.93470 -4.24636  -40.25040 1.000 22.55854 ? 297  ASP   A N   1 
ATOM   2194 C CA  . ASP   A 1 315 ? -23.74397 -3.46659  -39.93380 1.000 22.87941 ? 297  ASP   A CA  1 
ATOM   2195 C C   . ASP   A 1 315 ? -23.37402 -3.66748  -38.46478 1.000 18.48233 ? 297  ASP   A C   1 
ATOM   2196 O O   . ASP   A 1 315 ? -24.14747 -4.23662  -37.68749 1.000 16.33367 ? 297  ASP   A O   1 
ATOM   2197 C CB  . ASP   A 1 315 ? -23.95352 -1.99623  -40.31323 1.000 30.35935 ? 297  ASP   A CB  1 
ATOM   2198 C CG  . ASP   A 1 315 ? -25.20517 -1.39258  -39.72665 1.000 43.10911 ? 297  ASP   A CG  1 
ATOM   2199 O OD1 . ASP   A 1 315 ? -25.66115 -1.84178  -38.65153 1.000 41.24735 ? 297  ASP   A OD1 1 
ATOM   2200 O OD2 . ASP   A 1 315 ? -25.72466 -0.44026  -40.35339 1.000 45.58849 ? 297  ASP   A OD2 1 
ATOM   2201 N N   . PRO   A 1 316 ? -22.16352 -3.26044  -38.06704 1.000 17.28816 ? 298  PRO   A N   1 
ATOM   2202 C CA  . PRO   A 1 316 ? -21.71165 -3.56881  -36.69654 1.000 14.65447 ? 298  PRO   A CA  1 
ATOM   2203 C C   . PRO   A 1 316 ? -22.61938 -3.04638  -35.59607 1.000 17.44516 ? 298  PRO   A C   1 
ATOM   2204 O O   . PRO   A 1 316 ? -22.79728 -3.74234  -34.59188 1.000 16.27727 ? 298  PRO   A O   1 
ATOM   2205 C CB  . PRO   A 1 316 ? -20.32524 -2.91625  -36.63981 1.000 17.68986 ? 298  PRO   A CB  1 
ATOM   2206 C CG  . PRO   A 1 316 ? -19.83920 -2.95574  -38.05408 1.000 20.96006 ? 298  PRO   A CG  1 
ATOM   2207 C CD  . PRO   A 1 316 ? -21.05819 -2.75707  -38.91093 1.000 18.38850 ? 298  PRO   A CD  1 
ATOM   2208 N N   . LEU   A 1 317 ? -23.19397 -1.84430  -35.73688 1.000 15.77344 ? 299  LEU   A N   1 
ATOM   2209 C CA  . LEU   A 1 317 ? -24.04135 -1.31626  -34.67109 1.000 13.96499 ? 299  LEU   A CA  1 
ATOM   2210 C C   . LEU   A 1 317 ? -25.23662 -2.22024  -34.41793 1.000 16.11303 ? 299  LEU   A C   1 
ATOM   2211 O O   . LEU   A 1 317 ? -25.62073 -2.44261  -33.26450 1.000 16.16097 ? 299  LEU   A O   1 
ATOM   2212 C CB  . LEU   A 1 317 ? -24.51015 0.10239   -35.00597 1.000 20.72494 ? 299  LEU   A CB  1 
ATOM   2213 C CG  . LEU   A 1 317 ? -23.58118 1.26902   -34.65619 1.000 25.54097 ? 299  LEU   A CG  1 
ATOM   2214 C CD1 . LEU   A 1 317 ? -24.20615 2.57724   -35.10087 1.000 31.49366 ? 299  LEU   A CD1 1 
ATOM   2215 C CD2 . LEU   A 1 317 ? -23.29762 1.31059   -33.16611 1.000 18.19922 ? 299  LEU   A CD2 1 
ATOM   2216 N N   . THR   A 1 318 ? -25.83915 -2.75383  -35.48504 1.000 18.48821 ? 300  THR   A N   1 
ATOM   2217 C CA  . THR   A 1 318 ? -26.94493 -3.68481  -35.31310 1.000 16.35205 ? 300  THR   A CA  1 
ATOM   2218 C C   . THR   A 1 318 ? -26.52286 -4.88361  -34.48090 1.000 14.79089 ? 300  THR   A C   1 
ATOM   2219 O O   . THR   A 1 318 ? -27.28194 -5.35054  -33.62328 1.000 16.71385 ? 300  THR   A O   1 
ATOM   2220 C CB  . THR   A 1 318 ? -27.46746 -4.14800  -36.67574 1.000 19.34915 ? 300  THR   A CB  1 
ATOM   2221 O OG1 . THR   A 1 318 ? -27.92547 -3.01381  -37.41720 1.000 21.27534 ? 300  THR   A OG1 1 
ATOM   2222 C CG2 . THR   A 1 318 ? -28.60876 -5.15781  -36.50856 1.000 17.01144 ? 300  THR   A CG2 1 
ATOM   2223 N N   . LEU   A 1 319 ? -25.30753 -5.38688  -34.71050 1.000 13.05012 ? 301  LEU   A N   1 
ATOM   2224 C CA  . LEU   A 1 319 ? -24.85863 -6.56398  -33.98044 1.000 10.89752 ? 301  LEU   A CA  1 
ATOM   2225 C C   . LEU   A 1 319 ? -24.52892 -6.22208  -32.53094 1.000 10.29954 ? 301  LEU   A C   1 
ATOM   2226 O O   . LEU   A 1 319 ? -24.84514 -7.00079  -31.62486 1.000 11.47145 ? 301  LEU   A O   1 
ATOM   2227 C CB  . LEU   A 1 319 ? -23.65036 -7.18930  -34.68739 1.000 15.01524 ? 301  LEU   A CB  1 
ATOM   2228 C CG  . LEU   A 1 319 ? -23.95674 -7.77058  -36.07567 1.000 16.44481 ? 301  LEU   A CG  1 
ATOM   2229 C CD1 . LEU   A 1 319 ? -22.66459 -8.10482  -36.81804 1.000 15.98969 ? 301  LEU   A CD1 1 
ATOM   2230 C CD2 . LEU   A 1 319 ? -24.85299 -8.99287  -35.95947 1.000 17.03811 ? 301  LEU   A CD2 1 
ATOM   2231 N N   . TYR   A 1 320 ? -23.88251 -5.07057  -32.29080 1.000 13.35664 ? 302  TYR   A N   1 
ATOM   2232 C CA  . TYR   A 1 320 ? -23.62567 -4.63971  -30.91355 1.000 11.38030 ? 302  TYR   A CA  1 
ATOM   2233 C C   . TYR   A 1 320 ? -24.92581 -4.53116  -30.12998 1.000 13.74958 ? 302  TYR   A C   1 
ATOM   2234 O O   . TYR   A 1 320 ? -25.02078 -5.00496  -28.98840 1.000 13.03825 ? 302  TYR   A O   1 
ATOM   2235 C CB  . TYR   A 1 320 ? -22.88190 -3.29655  -30.88086 1.000 11.82185 ? 302  TYR   A CB  1 
ATOM   2236 C CG  . TYR   A 1 320 ? -21.46329 -3.33486  -31.41731 1.000 15.62736 ? 302  TYR   A CG  1 
ATOM   2237 C CD1 . TYR   A 1 320 ? -20.50537 -4.18226  -30.85709 1.000 11.71510 ? 302  TYR   A CD1 1 
ATOM   2238 C CD2 . TYR   A 1 320 ? -21.07622 -2.50416  -32.46363 1.000 10.55619 ? 302  TYR   A CD2 1 
ATOM   2239 C CE1 . TYR   A 1 320 ? -19.20236 -4.20860  -31.34132 1.000 13.04481 ? 302  TYR   A CE1 1 
ATOM   2240 C CE2 . TYR   A 1 320 ? -19.78297 -2.53640  -32.96450 1.000 12.93043 ? 302  TYR   A CE2 1 
ATOM   2241 C CZ  . TYR   A 1 320 ? -18.85000 -3.39161  -32.39820 1.000 11.90849 ? 302  TYR   A CZ  1 
ATOM   2242 O OH  . TYR   A 1 320 ? -17.56127 -3.42994  -32.88542 1.000 14.07760 ? 302  TYR   A OH  1 
ATOM   2243 N N   . HIS   A 1 321 ? -25.94866 -3.90951  -30.73131 1.000 11.14760 ? 303  HIS   A N   1 
ATOM   2244 C CA  . HIS   A 1 321 ? -27.23909 -3.81179  -30.05761 1.000 13.55285 ? 303  HIS   A CA  1 
ATOM   2245 C C   . HIS   A 1 321 ? -27.90817 -5.17551  -29.89611 1.000 13.59186 ? 303  HIS   A C   1 
ATOM   2246 O O   . HIS   A 1 321 ? -28.65393 -5.38425  -28.93062 1.000 11.47639 ? 303  HIS   A O   1 
ATOM   2247 C CB  . HIS   A 1 321 ? -28.13973 -2.82058  -30.80427 1.000 16.08629 ? 303  HIS   A CB  1 
ATOM   2248 C CG  . HIS   A 1 321 ? -27.72195 -1.39651  -30.60803 1.000 18.64440 ? 303  HIS   A CG  1 
ATOM   2249 N ND1 . HIS   A 1 321 ? -27.74510 -0.78186  -29.37439 1.000 25.65176 ? 303  HIS   A ND1 1 
ATOM   2250 C CD2 . HIS   A 1 321 ? -27.21600 -0.48571  -31.47250 1.000 21.11654 ? 303  HIS   A CD2 1 
ATOM   2251 C CE1 . HIS   A 1 321 ? -27.29228 0.45464   -29.49248 1.000 26.79790 ? 303  HIS   A CE1 1 
ATOM   2252 N NE2 . HIS   A 1 321 ? -26.96332 0.65903   -30.75524 1.000 22.61069 ? 303  HIS   A NE2 1 
ATOM   2253 N N   . LYS   A 1 322 ? -27.63008 -6.12552  -30.78955 1.000 12.77159 ? 304  LYS   A N   1 
ATOM   2254 C CA  . LYS   A 1 322 ? -28.14862 -7.48008  -30.59024 1.000 15.34114 ? 304  LYS   A CA  1 
ATOM   2255 C C   . LYS   A 1 322 ? -27.51522 -8.14918  -29.37291 1.000 11.35509 ? 304  LYS   A C   1 
ATOM   2256 O O   . LYS   A 1 322 ? -28.18849 -8.88453  -28.64405 1.000 13.84262 ? 304  LYS   A O   1 
ATOM   2257 C CB  . LYS   A 1 322 ? -27.91693 -8.32865  -31.83880 1.000 16.49842 ? 304  LYS   A CB  1 
ATOM   2258 C CG  . LYS   A 1 322 ? -28.89312 -8.06510  -32.98368 1.000 27.75546 ? 304  LYS   A CG  1 
ATOM   2259 C CD  . LYS   A 1 322 ? -28.81223 -9.17975  -34.02169 1.000 29.76146 ? 304  LYS   A CD  1 
ATOM   2260 C CE  . LYS   A 1 322 ? -30.13894 -9.38433  -34.75556 1.000 38.02274 ? 304  LYS   A CE  1 
ATOM   2261 N NZ  . LYS   A 1 322 ? -30.64122 -8.12267  -35.35026 1.000 44.57871 ? 304  LYS   A NZ  1 
ATOM   2262 N N   . GLY   A 1 323 ? -26.21720 -7.92935  -29.15758 1.000 11.60457 ? 305  GLY   A N   1 
ATOM   2263 C CA  . GLY   A 1 323 ? -25.57093 -8.47956  -27.98101 1.000 9.55834  ? 305  GLY   A CA  1 
ATOM   2264 C C   . GLY   A 1 323 ? -26.10084 -7.87701  -26.69437 1.000 8.96440  ? 305  GLY   A C   1 
ATOM   2265 O O   . GLY   A 1 323 ? -26.26699 -8.57990  -25.69673 1.000 11.50834 ? 305  GLY   A O   1 
ATOM   2266 N N   . ILE   A 1 324 ? -26.38167 -6.56773  -26.70090 1.000 12.26514 ? 306  ILE   A N   1 
ATOM   2267 C CA  . ILE   A 1 324 ? -26.97788 -5.93267  -25.52907 1.000 16.54748 ? 306  ILE   A CA  1 
ATOM   2268 C C   . ILE   A 1 324 ? -28.37923 -6.47896  -25.28574 1.000 13.40785 ? 306  ILE   A C   1 
ATOM   2269 O O   . ILE   A 1 324 ? -28.75713 -6.77774  -24.14271 1.000 14.70797 ? 306  ILE   A O   1 
ATOM   2270 C CB  . ILE   A 1 324 ? -26.98446 -4.39936  -25.69744 1.000 11.56452 ? 306  ILE   A CB  1 
ATOM   2271 C CG1 . ILE   A 1 324 ? -25.55842 -3.85972  -25.61541 1.000 12.87489 ? 306  ILE   A CG1 1 
ATOM   2272 C CG2 . ILE   A 1 324 ? -27.85955 -3.72886  -24.62443 1.000 12.48470 ? 306  ILE   A CG2 1 
ATOM   2273 C CD1 . ILE   A 1 324 ? -25.41041 -2.42083  -26.08726 1.000 14.19516 ? 306  ILE   A CD1 1 
ATOM   2274 N N   . ALA   A 1 325 ? -29.16544 -6.63242  -26.35697 1.000 12.61688 ? 307  ALA   A N   1 
ATOM   2275 C CA  . ALA   A 1 325 ? -30.50248 -7.19542  -26.22137 1.000 13.08138 ? 307  ALA   A CA  1 
ATOM   2276 C C   . ALA   A 1 325 ? -30.44428 -8.62488  -25.70255 1.000 15.24493 ? 307  ALA   A C   1 
ATOM   2277 O O   . ALA   A 1 325 ? -31.29471 -9.04170  -24.90685 1.000 13.63510 ? 307  ALA   A O   1 
ATOM   2278 C CB  . ALA   A 1 325 ? -31.23339 -7.14066  -27.56315 1.000 17.23919 ? 307  ALA   A CB  1 
ATOM   2279 N N   . SER   A 1 326 ? -29.44242 -9.38920  -26.14247 1.000 13.16589 ? 308  SER   A N   1 
ATOM   2280 C CA  . SER   A 1 326 ? -29.25692 -10.74613 -25.63673 1.000 11.34369 ? 308  SER   A CA  1 
ATOM   2281 C C   . SER   A 1 326 ? -28.96693 -10.74096 -24.14061 1.000 9.33966  ? 308  SER   A C   1 
ATOM   2282 O O   . SER   A 1 326 ? -29.56707 -11.50683 -23.37823 1.000 11.50817 ? 308  SER   A O   1 
ATOM   2283 C CB  . SER   A 1 326 ? -28.13119 -11.43948 -26.41210 1.000 14.73052 ? 308  SER   A CB  1 
ATOM   2284 O OG  . SER   A 1 326 ? -27.86653 -12.72442 -25.87200 1.000 15.58652 ? 308  SER   A OG  1 
ATOM   2285 N N   . ALA   A 1 327 ? -28.05865 -9.86881  -23.69394 1.000 10.20853 ? 309  ALA   A N   1 
ATOM   2286 C CA  . ALA   A 1 327 ? -27.73122 -9.81590  -22.27236 1.000 10.29608 ? 309  ALA   A CA  1 
ATOM   2287 C C   . ALA   A 1 327 ? -28.93837 -9.39329  -21.43814 1.000 14.09361 ? 309  ALA   A C   1 
ATOM   2288 O O   . ALA   A 1 327 ? -29.16871 -9.92842  -20.34449 1.000 12.43331 ? 309  ALA   A O   1 
ATOM   2289 C CB  . ALA   A 1 327 ? -26.55457 -8.86831  -22.04071 1.000 9.64759  ? 309  ALA   A CB  1 
ATOM   2290 N N   . LYS   A 1 328 ? -29.72539 -8.43933  -21.94304 1.000 10.64885 ? 310  LYS   A N   1 
ATOM   2291 C CA  . LYS   A 1 328 ? -30.95404 -8.05163  -21.25593 1.000 12.69517 ? 310  LYS   A CA  1 
ATOM   2292 C C   . LYS   A 1 328 ? -31.94494 -9.20295  -21.21860 1.000 13.87473 ? 310  LYS   A C   1 
ATOM   2293 O O   . LYS   A 1 328 ? -32.56479 -9.46566  -20.18192 1.000 15.32168 ? 310  LYS   A O   1 
ATOM   2294 C CB  . LYS   A 1 328 ? -31.59492 -6.83983  -21.94209 1.000 12.41203 ? 310  LYS   A CB  1 
ATOM   2295 C CG  . LYS   A 1 328 ? -30.82098 -5.52391  -21.79155 1.000 13.83953 ? 310  LYS   A CG  1 
ATOM   2296 C CD  . LYS   A 1 328 ? -31.47942 -4.43525  -22.64815 1.000 13.63401 ? 310  LYS   A CD  1 
ATOM   2297 C CE  . LYS   A 1 328 ? -30.75952 -3.09545  -22.58032 1.000 22.49528 ? 310  LYS   A CE  1 
ATOM   2298 N NZ  . LYS   A 1 328 ? -30.78646 -2.50142  -21.21225 1.000 35.61282 ? 310  LYS   A NZ  1 
ATOM   2299 N N   . THR   A 1 329 ? -32.10422 -9.90306  -22.34213 1.000 15.34866 ? 311  THR   A N   1 
ATOM   2300 C CA  . THR   A 1 329 ? -33.14916 -10.91631 -22.44875 1.000 16.40763 ? 311  THR   A CA  1 
ATOM   2301 C C   . THR   A 1 329 ? -32.82576 -12.13839 -21.60040 1.000 15.85209 ? 311  THR   A C   1 
ATOM   2302 O O   . THR   A 1 329 ? -33.68212 -12.63953 -20.85958 1.000 14.82693 ? 311  THR   A O   1 
ATOM   2303 C CB  . THR   A 1 329 ? -33.33137 -11.32206 -23.91116 1.000 15.60232 ? 311  THR   A CB  1 
ATOM   2304 O OG1 . THR   A 1 329 ? -33.81345 -10.20021 -24.65800 1.000 17.45971 ? 311  THR   A OG1 1 
ATOM   2305 C CG2 . THR   A 1 329 ? -34.31923 -12.50384 -24.04151 1.000 14.79143 ? 311  THR   A CG2 1 
ATOM   2306 N N   . TYR   A 1 330 ? -31.59532 -12.64284 -21.69826 1.000 16.23408 ? 312  TYR   A N   1 
ATOM   2307 C CA  . TYR   A 1 330 ? -31.28674 -13.93699 -21.09978 1.000 22.41183 ? 312  TYR   A CA  1 
ATOM   2308 C C   . TYR   A 1 330 ? -30.48218 -13.85183 -19.81309 1.000 18.15748 ? 312  TYR   A C   1 
ATOM   2309 O O   . TYR   A 1 330 ? -30.46865 -14.82465 -19.05341 1.000 13.65033 ? 312  TYR   A O   1 
ATOM   2310 C CB  . TYR   A 1 330 ? -30.53891 -14.81970 -22.10922 1.000 13.88841 ? 312  TYR   A CB  1 
ATOM   2311 C CG  . TYR   A 1 330 ? -31.35350 -15.06624 -23.35601 1.000 15.31457 ? 312  TYR   A CG  1 
ATOM   2312 C CD1 . TYR   A 1 330 ? -32.42687 -15.94448 -23.34331 1.000 17.68070 ? 312  TYR   A CD1 1 
ATOM   2313 C CD2 . TYR   A 1 330 ? -31.05302 -14.41053 -24.54360 1.000 15.39460 ? 312  TYR   A CD2 1 
ATOM   2314 C CE1 . TYR   A 1 330 ? -33.18480 -16.16320 -24.48088 1.000 21.93183 ? 312  TYR   A CE1 1 
ATOM   2315 C CE2 . TYR   A 1 330 ? -31.80128 -14.61650 -25.68398 1.000 21.25843 ? 312  TYR   A CE2 1 
ATOM   2316 C CZ  . TYR   A 1 330 ? -32.86631 -15.49494 -25.64651 1.000 22.53689 ? 312  TYR   A CZ  1 
ATOM   2317 O OH  . TYR   A 1 330 ? -33.60576 -15.70119 -26.78272 1.000 28.72299 ? 312  TYR   A OH  1 
ATOM   2318 N N   . TYR   A 1 331 ? -29.83766 -12.71926 -19.52902 1.000 13.39782 ? 313  TYR   A N   1 
ATOM   2319 C CA  . TYR   A 1 331 ? -28.93806 -12.64624 -18.38251 1.000 12.66581 ? 313  TYR   A CA  1 
ATOM   2320 C C   . TYR   A 1 331 ? -29.24514 -11.45601 -17.48257 1.000 9.56620  ? 313  TYR   A C   1 
ATOM   2321 O O   . TYR   A 1 331 ? -28.36158 -10.94403 -16.80616 1.000 13.02195 ? 313  TYR   A O   1 
ATOM   2322 C CB  . TYR   A 1 331 ? -27.48548 -12.62811 -18.84580 1.000 12.10480 ? 313  TYR   A CB  1 
ATOM   2323 C CG  . TYR   A 1 331 ? -27.21220 -13.79631 -19.76502 1.000 11.86234 ? 313  TYR   A CG  1 
ATOM   2324 C CD1 . TYR   A 1 331 ? -27.16690 -15.09176 -19.26157 1.000 10.24996 ? 313  TYR   A CD1 1 
ATOM   2325 C CD2 . TYR   A 1 331 ? -27.03554 -13.61264 -21.12759 1.000 10.44992 ? 313  TYR   A CD2 1 
ATOM   2326 C CE1 . TYR   A 1 331 ? -26.94578 -16.17384 -20.08623 1.000 16.33540 ? 313  TYR   A CE1 1 
ATOM   2327 C CE2 . TYR   A 1 331 ? -26.80140 -14.70467 -21.97274 1.000 15.53853 ? 313  TYR   A CE2 1 
ATOM   2328 C CZ  . TYR   A 1 331 ? -26.75436 -15.97669 -21.43935 1.000 17.25380 ? 313  TYR   A CZ  1 
ATOM   2329 O OH  . TYR   A 1 331 ? -26.52726 -17.06655 -22.25443 1.000 16.47727 ? 313  TYR   A OH  1 
ATOM   2330 N N   . ARG   A 1 332 ? -30.50159 -11.02107 -17.44719 1.000 10.98419 ? 314  ARG   A N   1 
ATOM   2331 C CA  . ARG   A 1 332 ? -30.95903 -10.04764 -16.46583 1.000 13.91521 ? 314  ARG   A CA  1 
ATOM   2332 C C   . ARG   A 1 332 ? -30.27445 -8.69830  -16.63102 1.000 14.69044 ? 314  ARG   A C   1 
ATOM   2333 O O   . ARG   A 1 332 ? -30.29791 -7.87742  -15.70745 1.000 13.12285 ? 314  ARG   A O   1 
ATOM   2334 C CB  . ARG   A 1 332 ? -30.73819 -10.57740 -15.04346 1.000 15.93406 ? 314  ARG   A CB  1 
ATOM   2335 C CG  . ARG   A 1 332 ? -31.77648 -11.59495 -14.61213 1.000 21.51872 ? 314  ARG   A CG  1 
ATOM   2336 C CD  . ARG   A 1 332 ? -31.36203 -12.30751 -13.35362 1.000 26.72284 ? 314  ARG   A CD  1 
ATOM   2337 N NE  . ARG   A 1 332 ? -32.25954 -12.01630 -12.24517 1.000 28.16059 ? 314  ARG   A NE  1 
ATOM   2338 C CZ  . ARG   A 1 332 ? -32.54468 -12.86855 -11.27004 1.000 29.43396 ? 314  ARG   A CZ  1 
ATOM   2339 N NH1 . ARG   A 1 332 ? -32.10069 -14.11915 -11.28897 1.000 39.33182 ? 314  ARG   A NH1 1 
ATOM   2340 N NH2 . ARG   A 1 332 ? -33.29372 -12.45898 -10.25342 1.000 30.46322 ? 314  ARG   A NH2 1 
ATOM   2341 N N   . ASP   A 1 333 ? -29.65353 -8.45849  -17.79098 1.000 13.79590 ? 315  ASP   A N   1 
ATOM   2342 C CA  . ASP   A 1 333 ? -28.87806 -7.23527  -18.02078 1.000 10.12874 ? 315  ASP   A CA  1 
ATOM   2343 C C   . ASP   A 1 333 ? -27.78278 -7.07499  -16.96819 1.000 13.04357 ? 315  ASP   A C   1 
ATOM   2344 O O   . ASP   A 1 333 ? -27.52146 -5.97399  -16.47731 1.000 13.99679 ? 315  ASP   A O   1 
ATOM   2345 C CB  . ASP   A 1 333 ? -29.78930 -6.00178  -18.04269 1.000 18.35358 ? 315  ASP   A CB  1 
ATOM   2346 C CG  . ASP   A 1 333 ? -29.16720 -4.81090  -18.75611 1.000 21.23267 ? 315  ASP   A CG  1 
ATOM   2347 O OD1 . ASP   A 1 333 ? -28.14538 -4.97454  -19.46273 1.000 15.36655 ? 315  ASP   A OD1 1 
ATOM   2348 O OD2 . ASP   A 1 333 ? -29.72507 -3.69992  -18.62051 1.000 18.39486 ? 315  ASP   A OD2 1 
ATOM   2349 N N   . GLU   A 1 334 ? -27.12777 -8.17966  -16.61334 1.000 11.14110 ? 316  GLU   A N   1 
ATOM   2350 C CA  . GLU   A 1 334 ? -26.06680 -8.15035  -15.61316 1.000 13.20094 ? 316  GLU   A CA  1 
ATOM   2351 C C   . GLU   A 1 334 ? -24.67919 -8.43128  -16.19628 1.000 10.94802 ? 316  GLU   A C   1 
ATOM   2352 O O   . GLU   A 1 334 ? -23.74166 -8.73212  -15.44311 1.000 12.30821 ? 316  GLU   A O   1 
ATOM   2353 C CB  . GLU   A 1 334 ? -26.40068 -9.12629  -14.48986 1.000 16.68719 ? 316  GLU   A CB  1 
ATOM   2354 C CG  . GLU   A 1 334 ? -27.39158 -8.50072  -13.52910 1.000 14.05294 ? 316  GLU   A CG  1 
ATOM   2355 C CD  . GLU   A 1 334 ? -27.93626 -9.45291  -12.48466 1.000 26.48532 ? 316  GLU   A CD  1 
ATOM   2356 O OE1 . GLU   A 1 334 ? -27.90159 -10.67793 -12.69916 1.000 22.84449 ? 316  GLU   A OE1 1 
ATOM   2357 O OE2 . GLU   A 1 334 ? -28.41946 -8.96096  -11.44393 1.000 21.69102 ? 316  GLU   A OE2 1 
ATOM   2358 N N   . HIS   A 1 335 ? -24.52688 -8.31865  -17.51268 1.000 10.62859 ? 317  HIS   A N   1 
ATOM   2359 C CA  . HIS   A 1 335 ? -23.23957 -8.44244  -18.19025 1.000 10.36754 ? 317  HIS   A CA  1 
ATOM   2360 C C   . HIS   A 1 335 ? -22.62740 -7.06840  -18.44316 1.000 11.98221 ? 317  HIS   A C   1 
ATOM   2361 O O   . HIS   A 1 335 ? -23.34048 -6.10469  -18.73468 1.000 12.62960 ? 317  HIS   A O   1 
ATOM   2362 C CB  . HIS   A 1 335 ? -23.40647 -9.17681  -19.51995 1.000 10.12045 ? 317  HIS   A CB  1 
ATOM   2363 C CG  . HIS   A 1 335 ? -23.69150 -10.63919 -19.36354 1.000 12.40802 ? 317  HIS   A CG  1 
ATOM   2364 N ND1 . HIS   A 1 335 ? -23.56282 -11.53653 -20.40033 1.000 13.86625 ? 317  HIS   A ND1 1 
ATOM   2365 C CD2 . HIS   A 1 335 ? -24.10408 -11.35759 -18.29183 1.000 12.27598 ? 317  HIS   A CD2 1 
ATOM   2366 C CE1 . HIS   A 1 335 ? -23.87269 -12.74729 -19.97140 1.000 11.47228 ? 317  HIS   A CE1 1 
ATOM   2367 N NE2 . HIS   A 1 335 ? -24.19895 -12.66679 -18.69385 1.000 10.29842 ? 317  HIS   A NE2 1 
ATOM   2368 N N   . ILE   A 1 336 ? -21.30414 -6.99303  -18.35655 1.000 9.19902  ? 318  ILE   A N   1 
ATOM   2369 C CA  . ILE   A 1 336 ? -20.57941 -5.73529  -18.55467 1.000 9.31253  ? 318  ILE   A CA  1 
ATOM   2370 C C   . ILE   A 1 336 ? -20.14396 -5.54975  -20.00422 1.000 9.20150  ? 318  ILE   A C   1 
ATOM   2371 O O   . ILE   A 1 336 ? -20.27977 -4.46135  -20.57507 1.000 12.83792 ? 318  ILE   A O   1 
ATOM   2372 C CB  . ILE   A 1 336 ? -19.36092 -5.66827  -17.60804 1.000 12.55825 ? 318  ILE   A CB  1 
ATOM   2373 C CG1 . ILE   A 1 336 ? -19.77321 -5.94192  -16.15400 1.000 16.42564 ? 318  ILE   A CG1 1 
ATOM   2374 C CG2 . ILE   A 1 336 ? -18.64862 -4.33035  -17.78177 1.000 15.29280 ? 318  ILE   A CG2 1 
ATOM   2375 C CD1 . ILE   A 1 336 ? -20.67600 -4.85137  -15.55323 1.000 14.31905 ? 318  ILE   A CD1 1 
ATOM   2376 N N   . TYR   A 1 337 ? -19.58298 -6.58963  -20.62184 1.000 9.91565  ? 319  TYR   A N   1 
ATOM   2377 C CA  . TYR   A 1 337 ? -18.96169 -6.40675  -21.93117 1.000 11.34308 ? 319  TYR   A CA  1 
ATOM   2378 C C   . TYR   A 1 337 ? -19.91636 -5.95811  -23.04675 1.000 11.45911 ? 319  TYR   A C   1 
ATOM   2379 O O   . TYR   A 1 337 ? -19.44725 -5.22975  -23.94024 1.000 9.81581  ? 319  TYR   A O   1 
ATOM   2380 C CB  . TYR   A 1 337 ? -18.23636 -7.70064  -22.33470 1.000 8.29176  ? 319  TYR   A CB  1 
ATOM   2381 C CG  . TYR   A 1 337 ? -16.94738 -7.94457  -21.57498 1.000 10.16370 ? 319  TYR   A CG  1 
ATOM   2382 C CD1 . TYR   A 1 337 ? -16.02773 -6.90879  -21.35729 1.000 13.80638 ? 319  TYR   A CD1 1 
ATOM   2383 C CD2 . TYR   A 1 337 ? -16.64081 -9.20609  -21.08343 1.000 9.89088  ? 319  TYR   A CD2 1 
ATOM   2384 C CE1 . TYR   A 1 337 ? -14.84563 -7.12886  -20.65634 1.000 11.17279 ? 319  TYR   A CE1 1 
ATOM   2385 C CE2 . TYR   A 1 337 ? -15.45232 -9.43997  -20.38940 1.000 11.53303 ? 319  TYR   A CE2 1 
ATOM   2386 C CZ  . TYR   A 1 337 ? -14.56187 -8.39931  -20.17939 1.000 13.38233 ? 319  TYR   A CZ  1 
ATOM   2387 O OH  . TYR   A 1 337 ? -13.38417 -8.61548  -19.47959 1.000 15.02886 ? 319  TYR   A OH  1 
ATOM   2388 N N   . PRO   A 1 338 ? -21.21374 -6.32397  -23.07266 1.000 10.88686 ? 320  PRO   A N   1 
ATOM   2389 C CA  . PRO   A 1 338 ? -22.07301 -5.81822  -24.16763 1.000 11.19499 ? 320  PRO   A CA  1 
ATOM   2390 C C   . PRO   A 1 338 ? -21.99688 -4.31174  -24.36836 1.000 14.18335 ? 320  PRO   A C   1 
ATOM   2391 O O   . PRO   A 1 338 ? -21.95084 -3.85460  -25.52073 1.000 11.49034 ? 320  PRO   A O   1 
ATOM   2392 C CB  . PRO   A 1 338 ? -23.48384 -6.26011  -23.74466 1.000 13.01983 ? 320  PRO   A CB  1 
ATOM   2393 C CG  . PRO   A 1 338 ? -23.24893 -7.51979  -22.95707 1.000 12.01091 ? 320  PRO   A CG  1 
ATOM   2394 C CD  . PRO   A 1 338 ? -21.93834 -7.29990  -22.22465 1.000 6.81592  ? 320  PRO   A CD  1 
ATOM   2395 N N   . TYR   A 1 339 ? -21.95573 -3.53152  -23.27736 1.000 12.63193 ? 321  TYR   A N   1 
ATOM   2396 C CA  . TYR   A 1 339 ? -21.83396 -2.08202  -23.38120 1.000 13.84748 ? 321  TYR   A CA  1 
ATOM   2397 C C   . TYR   A 1 339 ? -20.41522 -1.63910  -23.71789 1.000 10.42884 ? 321  TYR   A C   1 
ATOM   2398 O O   . TYR   A 1 339 ? -20.23832 -0.59915  -24.36964 1.000 11.01454 ? 321  TYR   A O   1 
ATOM   2399 C CB  . TYR   A 1 339 ? -22.32661 -1.41486  -22.08175 1.000 8.99942  ? 321  TYR   A CB  1 
ATOM   2400 C CG  . TYR   A 1 339 ? -23.75256 -1.81586  -21.76782 1.000 15.36572 ? 321  TYR   A CG  1 
ATOM   2401 C CD1 . TYR   A 1 339 ? -24.81971 -1.20543  -22.42222 1.000 15.97296 ? 321  TYR   A CD1 1 
ATOM   2402 C CD2 . TYR   A 1 339 ? -24.03356 -2.82839  -20.85169 1.000 10.58517 ? 321  TYR   A CD2 1 
ATOM   2403 C CE1 . TYR   A 1 339 ? -26.13252 -1.58707  -22.17033 1.000 15.68170 ? 321  TYR   A CE1 1 
ATOM   2404 C CE2 . TYR   A 1 339 ? -25.34860 -3.21934  -20.59774 1.000 10.76621 ? 321  TYR   A CE2 1 
ATOM   2405 C CZ  . TYR   A 1 339 ? -26.38826 -2.58608  -21.25245 1.000 11.64288 ? 321  TYR   A CZ  1 
ATOM   2406 O OH  . TYR   A 1 339 ? -27.69076 -2.95626  -21.01135 1.000 12.84334 ? 321  TYR   A OH  1 
ATOM   2407 N N   . MET   A 1 340 ? -19.39216 -2.39815  -23.31216 1.000 11.37372 ? 322  MET   A N   1 
ATOM   2408 C CA  . MET   A 1 340 ? -18.03219 -2.00639  -23.67531 1.000 12.44475 ? 322  MET   A CA  1 
ATOM   2409 C C   . MET   A 1 340 ? -17.77160 -2.22665  -25.16324 1.000 12.12320 ? 322  MET   A C   1 
ATOM   2410 O O   . MET   A 1 340 ? -17.07197 -1.42722  -25.80187 1.000 11.43763 ? 322  MET   A O   1 
ATOM   2411 C CB  . MET   A 1 340 ? -17.00416 -2.76214  -22.83046 1.000 10.46989 ? 322  MET   A CB  1 
ATOM   2412 C CG  . MET   A 1 340 ? -16.95043 -2.27927  -21.38464 1.000 17.31712 ? 322  MET   A CG  1 
ATOM   2413 S SD  . MET   A 1 340 ? -15.74122 -3.20039  -20.42898 1.000 21.95957 ? 322  MET   A SD  1 
ATOM   2414 C CE  . MET   A 1 340 ? -15.42668 -2.11267  -19.04269 1.000 18.15877 ? 322  MET   A CE  1 
ATOM   2415 N N   . TYR   A 1 341 ? -18.31318 -3.30785  -25.73044 1.000 11.40603 ? 323  TYR   A N   1 
ATOM   2416 C CA  . TYR   A 1 341 ? -18.24366 -3.49142  -27.17754 1.000 11.08833 ? 323  TYR   A CA  1 
ATOM   2417 C C   . TYR   A 1 341 ? -18.81187 -2.27847  -27.89691 1.000 10.04831 ? 323  TYR   A C   1 
ATOM   2418 O O   . TYR   A 1 341 ? -18.18051 -1.71095  -28.79983 1.000 12.77476 ? 323  TYR   A O   1 
ATOM   2419 C CB  . TYR   A 1 341 ? -19.02896 -4.72939  -27.60256 1.000 8.96621  ? 323  TYR   A CB  1 
ATOM   2420 C CG  . TYR   A 1 341 ? -18.29271 -6.04678  -27.50937 1.000 12.12678 ? 323  TYR   A CG  1 
ATOM   2421 C CD1 . TYR   A 1 341 ? -17.25570 -6.35728  -28.38157 1.000 14.27133 ? 323  TYR   A CD1 1 
ATOM   2422 C CD2 . TYR   A 1 341 ? -18.68146 -7.00689  -26.58037 1.000 11.32267 ? 323  TYR   A CD2 1 
ATOM   2423 C CE1 . TYR   A 1 341 ? -16.59472 -7.58690  -28.30363 1.000 15.19464 ? 323  TYR   A CE1 1 
ATOM   2424 C CE2 . TYR   A 1 341 ? -18.03455 -8.24309  -26.49868 1.000 10.80163 ? 323  TYR   A CE2 1 
ATOM   2425 C CZ  . TYR   A 1 341 ? -16.99709 -8.52468  -27.36292 1.000 12.54494 ? 323  TYR   A CZ  1 
ATOM   2426 O OH  . TYR   A 1 341 ? -16.35295 -9.74468  -27.28091 1.000 14.62455 ? 323  TYR   A OH  1 
ATOM   2427 N N   . LEU   A 1 342 ? -20.02022 -1.88099  -27.50768 1.000 10.35265 ? 324  LEU   A N   1 
ATOM   2428 C CA  . LEU   A 1 342 ? -20.69909 -0.76684  -28.16091 1.000 10.30986 ? 324  LEU   A CA  1 
ATOM   2429 C C   . LEU   A 1 342 ? -19.93331 0.53279   -27.96374 1.000 10.92768 ? 324  LEU   A C   1 
ATOM   2430 O O   . LEU   A 1 342 ? -19.69959 1.27721   -28.92119 1.000 12.93323 ? 324  LEU   A O   1 
ATOM   2431 C CB  . LEU   A 1 342 ? -22.12576 -0.63665  -27.62481 1.000 13.58131 ? 324  LEU   A CB  1 
ATOM   2432 C CG  . LEU   A 1 342 ? -22.87636 0.58566   -28.16016 1.000 12.84647 ? 324  LEU   A CG  1 
ATOM   2433 C CD1 . LEU   A 1 342 ? -23.11984 0.39685   -29.64589 1.000 10.64123 ? 324  LEU   A CD1 1 
ATOM   2434 C CD2 . LEU   A 1 342 ? -24.19542 0.79293   -27.42813 1.000 13.32692 ? 324  LEU   A CD2 1 
ATOM   2435 N N   . ALA   A 1 343 ? -19.52735 0.82001   -26.72445 1.000 10.30036 ? 325  ALA   A N   1 
ATOM   2436 C CA  . ALA   A 1 343 ? -18.78199 2.04951   -26.45478 1.000 11.93235 ? 325  ALA   A CA  1 
ATOM   2437 C C   . ALA   A 1 343 ? -17.50795 2.13010   -27.28940 1.000 13.59668 ? 325  ALA   A C   1 
ATOM   2438 O O   . ALA   A 1 343 ? -17.17463 3.19268   -27.83181 1.000 15.26162 ? 325  ALA   A O   1 
ATOM   2439 C CB  . ALA   A 1 343 ? -18.44808 2.14163   -24.96304 1.000 9.95516  ? 325  ALA   A CB  1 
ATOM   2440 N N   . GLY   A 1 344 ? -16.78118 1.01581   -27.40495 1.000 15.66042 ? 326  GLY   A N   1 
ATOM   2441 C CA  . GLY   A 1 344 ? -15.53923 1.03316   -28.15447 1.000 11.05452 ? 326  GLY   A CA  1 
ATOM   2442 C C   . GLY   A 1 344 ? -15.74708 1.36182   -29.62117 1.000 11.95486 ? 326  GLY   A C   1 
ATOM   2443 O O   . GLY   A 1 344 ? -14.96663 2.10162   -30.21971 1.000 13.81785 ? 326  GLY   A O   1 
ATOM   2444 N N   . TYR   A 1 345 ? -16.79310 0.80651   -30.22381 1.000 15.12051 ? 327  TYR   A N   1 
ATOM   2445 C CA  . TYR   A 1 345 ? -17.08866 1.13994   -31.60937 1.000 17.08071 ? 327  TYR   A CA  1 
ATOM   2446 C C   . TYR   A 1 345 ? -17.38881 2.62906   -31.75413 1.000 16.21811 ? 327  TYR   A C   1 
ATOM   2447 O O   . TYR   A 1 345 ? -16.86673 3.29870   -32.65287 1.000 15.14642 ? 327  TYR   A O   1 
ATOM   2448 C CB  . TYR   A 1 345 ? -18.25829 0.29865   -32.09510 1.000 9.18236  ? 327  TYR   A CB  1 
ATOM   2449 C CG  . TYR   A 1 345 ? -18.63016 0.53431   -33.53797 1.000 19.49879 ? 327  TYR   A CG  1 
ATOM   2450 C CD1 . TYR   A 1 345 ? -17.94641 -0.11460  -34.55951 1.000 20.07038 ? 327  TYR   A CD1 1 
ATOM   2451 C CD2 . TYR   A 1 345 ? -19.67108 1.39158   -33.87895 1.000 24.17618 ? 327  TYR   A CD2 1 
ATOM   2452 C CE1 . TYR   A 1 345 ? -18.27630 0.08564   -35.88509 1.000 20.31437 ? 327  TYR   A CE1 1 
ATOM   2453 C CE2 . TYR   A 1 345 ? -20.01596 1.60266   -35.20774 1.000 23.83410 ? 327  TYR   A CE2 1 
ATOM   2454 C CZ  . TYR   A 1 345 ? -19.31197 0.94781   -36.20457 1.000 30.99223 ? 327  TYR   A CZ  1 
ATOM   2455 O OH  . TYR   A 1 345 ? -19.64437 1.14428   -37.52515 1.000 29.18904 ? 327  TYR   A OH  1 
ATOM   2456 N N   . HIS   A 1 346 ? -18.22776 3.16628   -30.86929 1.000 14.93569 ? 328  HIS   A N   1 
ATOM   2457 C CA  . HIS   A 1 346 ? -18.53754 4.58983   -30.93558 1.000 11.33546 ? 328  HIS   A CA  1 
ATOM   2458 C C   . HIS   A 1 346 ? -17.28595 5.42768   -30.75407 1.000 20.59010 ? 328  HIS   A C   1 
ATOM   2459 O O   . HIS   A 1 346 ? -17.15416 6.49431   -31.37038 1.000 18.16008 ? 328  HIS   A O   1 
ATOM   2460 C CB  . HIS   A 1 346 ? -19.56593 4.96195   -29.87423 1.000 13.54323 ? 328  HIS   A CB  1 
ATOM   2461 C CG  . HIS   A 1 346 ? -20.97241 4.58696   -30.22894 1.000 14.90620 ? 328  HIS   A CG  1 
ATOM   2462 N ND1 . HIS   A 1 346 ? -21.53498 4.87693   -31.45266 1.000 17.14845 ? 328  HIS   A ND1 1 
ATOM   2463 C CD2 . HIS   A 1 346 ? -21.93941 3.97182   -29.50645 1.000 17.69934 ? 328  HIS   A CD2 1 
ATOM   2464 C CE1 . HIS   A 1 346 ? -22.78630 4.45348   -31.47101 1.000 19.51291 ? 328  HIS   A CE1 1 
ATOM   2465 N NE2 . HIS   A 1 346 ? -23.05550 3.89698   -30.30310 1.000 18.09786 ? 328  HIS   A NE2 1 
ATOM   2466 N N   . CYS   A 1 347 ? -16.36117 4.95406   -29.91389 1.000 18.35579 ? 329  CYS   A N   1 
ATOM   2467 C CA  . CYS   A 1 347 ? -15.12753 5.68043   -29.66409 1.000 17.42375 ? 329  CYS   A CA  1 
ATOM   2468 C C   . CYS   A 1 347 ? -14.25696 5.71905   -30.91404 1.000 23.16781 ? 329  CYS   A C   1 
ATOM   2469 O O   . CYS   A 1 347 ? -13.84015 6.79395   -31.35573 1.000 17.24777 ? 329  CYS   A O   1 
ATOM   2470 C CB  . CYS   A 1 347 ? -14.38479 5.04119   -28.48966 1.000 20.54266 ? 329  CYS   A CB  1 
ATOM   2471 S SG  . CYS   A 1 347 ? -12.91853 5.91499   -28.04018 1.000 36.01967 ? 329  CYS   A SG  1 
ATOM   2472 N N   . ARG   A 1 348 ? -14.00172 4.55693   -31.52537 1.000 18.87441 ? 330  ARG   A N   1 
ATOM   2473 C CA  . ARG   A 1 348 ? -13.21228 4.53957   -32.75560 1.000 21.00353 ? 330  ARG   A CA  1 
ATOM   2474 C C   . ARG   A 1 348 ? -13.88876 5.28090   -33.90689 1.000 21.80136 ? 330  ARG   A C   1 
ATOM   2475 O O   . ARG   A 1 348 ? -13.20914 5.66548   -34.86401 1.000 25.16011 ? 330  ARG   A O   1 
ATOM   2476 C CB  . ARG   A 1 348 ? -12.91141 3.09969   -33.16492 1.000 21.10473 ? 330  ARG   A CB  1 
ATOM   2477 C CG  . ARG   A 1 348 ? -12.24744 2.28277   -32.06121 1.000 21.66281 ? 330  ARG   A CG  1 
ATOM   2478 C CD  . ARG   A 1 348 ? -11.87975 0.90335   -32.57460 1.000 22.52262 ? 330  ARG   A CD  1 
ATOM   2479 N NE  . ARG   A 1 348 ? -13.04643 0.03848   -32.68639 1.000 17.44961 ? 330  ARG   A NE  1 
ATOM   2480 C CZ  . ARG   A 1 348 ? -13.58860 -0.63133  -31.67545 1.000 22.77064 ? 330  ARG   A CZ  1 
ATOM   2481 N NH1 . ARG   A 1 348 ? -13.10011 -0.54911  -30.44889 1.000 19.36429 ? 330  ARG   A NH1 1 
ATOM   2482 N NH2 . ARG   A 1 348 ? -14.63558 -1.41927  -31.90688 1.000 16.54033 ? 330  ARG   A NH2 1 
ATOM   2483 N N   . ASN   A 1 349 ? -15.19945 5.49773   -33.83976 1.000 20.62328 ? 331  ASN   A N   1 
ATOM   2484 C CA  . ASN   A 1 349 ? -15.92082 6.22587   -34.87366 1.000 20.75341 ? 331  ASN   A CA  1 
ATOM   2485 C C   . ASN   A 1 349 ? -16.22034 7.67130   -34.47922 1.000 22.41908 ? 331  ASN   A C   1 
ATOM   2486 O O   . ASN   A 1 349 ? -16.98416 8.34895   -35.17553 1.000 23.66181 ? 331  ASN   A O   1 
ATOM   2487 C CB  . ASN   A 1 349 ? -17.20639 5.47609   -35.23261 1.000 22.60048 ? 331  ASN   A CB  1 
ATOM   2488 C CG  . ASN   A 1 349 ? -16.93146 4.22397   -36.03234 1.000 23.28159 ? 331  ASN   A CG  1 
ATOM   2489 O OD1 . ASN   A 1 349 ? -17.04587 3.10764   -35.52423 1.000 32.58587 ? 331  ASN   A OD1 1 
ATOM   2490 N ND2 . ASN   A 1 349 ? -16.56153 4.39834   -37.29283 1.000 29.04143 ? 331  ASN   A ND2 1 
ATOM   2491 N N   . ARG   A 1 350 ? -15.62600 8.15371   -33.38419 1.000 19.22912 ? 332  ARG   A N   1 
ATOM   2492 C CA  . ARG   A 1 350 ? -15.69337 9.55816   -32.96944 1.000 20.45273 ? 332  ARG   A CA  1 
ATOM   2493 C C   . ARG   A 1 350 ? -17.12597 9.99990   -32.68459 1.000 26.84677 ? 332  ARG   A C   1 
ATOM   2494 O O   . ARG   A 1 350 ? -17.47755 11.17050  -32.84231 1.000 23.37122 ? 332  ARG   A O   1 
ATOM   2495 C CB  . ARG   A 1 350 ? -15.02574 10.45829  -34.01514 1.000 27.36259 ? 332  ARG   A CB  1 
ATOM   2496 C CG  . ARG   A 1 350 ? -13.58621 10.02034  -34.27610 1.000 29.64955 ? 332  ARG   A CG  1 
ATOM   2497 C CD  . ARG   A 1 350 ? -12.79762 10.95946  -35.18310 1.000 34.89009 ? 332  ARG   A CD  1 
ATOM   2498 N NE  . ARG   A 1 350 ? -12.66156 12.29877  -34.62546 1.000 53.71101 ? 332  ARG   A NE  1 
ATOM   2499 C CZ  . ARG   A 1 350 ? -11.78290 13.19748  -35.05025 1.000 51.55630 ? 332  ARG   A CZ  1 
ATOM   2500 N NH1 . ARG   A 1 350 ? -10.96893 12.94600  -36.06437 1.000 44.98275 ? 332  ARG   A NH1 1 
ATOM   2501 N NH2 . ARG   A 1 350 ? -11.70526 14.36958  -34.43007 1.000 46.59961 ? 332  ARG   A NH2 1 
ATOM   2502 N N   . ASN   A 1 351 ? -17.96719 9.05743   -32.26185 1.000 20.34547 ? 333  ASN   A N   1 
ATOM   2503 C CA  . ASN   A 1 351 ? -19.30456 9.36791   -31.76163 1.000 15.78274 ? 333  ASN   A CA  1 
ATOM   2504 C C   . ASN   A 1 351 ? -19.19144 9.57528   -30.25298 1.000 16.88943 ? 333  ASN   A C   1 
ATOM   2505 O O   . ASN   A 1 351 ? -19.43706 8.67451   -29.44734 1.000 14.25277 ? 333  ASN   A O   1 
ATOM   2506 C CB  . ASN   A 1 351 ? -20.28001 8.25064   -32.11194 1.000 19.46313 ? 333  ASN   A CB  1 
ATOM   2507 C CG  . ASN   A 1 351 ? -20.35724 7.98626   -33.61209 1.000 27.49619 ? 333  ASN   A CG  1 
ATOM   2508 O OD1 . ASN   A 1 351 ? -20.17151 8.89157   -34.42610 1.000 26.94463 ? 333  ASN   A OD1 1 
ATOM   2509 N ND2 . ASN   A 1 351 ? -20.61894 6.73628   -33.97958 1.000 20.62194 ? 333  ASN   A ND2 1 
ATOM   2510 N N   . VAL   A 1 352 ? -18.82002 10.80198  -29.86996 1.000 17.46849 ? 334  VAL   A N   1 
ATOM   2511 C CA  . VAL   A 1 352 ? -18.43801 11.07275  -28.48183 1.000 19.42173 ? 334  VAL   A CA  1 
ATOM   2512 C C   . VAL   A 1 352 ? -19.63351 10.92381  -27.54708 1.000 18.32951 ? 334  VAL   A C   1 
ATOM   2513 O O   . VAL   A 1 352 ? -19.53783 10.28084  -26.49440 1.000 16.56053 ? 334  VAL   A O   1 
ATOM   2514 C CB  . VAL   A 1 352 ? -17.80951 12.47264  -28.35804 1.000 19.74739 ? 334  VAL   A CB  1 
ATOM   2515 C CG1 . VAL   A 1 352 ? -17.40707 12.74128  -26.91296 1.000 17.90768 ? 334  VAL   A CG1 1 
ATOM   2516 C CG2 . VAL   A 1 352 ? -16.62409 12.62759  -29.30916 1.000 17.31590 ? 334  VAL   A CG2 1 
ATOM   2517 N N   . ARG   A 1 353 ? -20.76637 11.54196  -27.89728 1.000 15.32789 ? 335  ARG   A N   1 
ATOM   2518 C CA  . ARG   A 1 353 ? -21.96592 11.43228  -27.06572 1.000 19.90612 ? 335  ARG   A CA  1 
ATOM   2519 C C   . ARG   A 1 353 ? -22.33567 9.97408   -26.82607 1.000 13.56402 ? 335  ARG   A C   1 
ATOM   2520 O O   . ARG   A 1 353 ? -22.56934 9.55206   -25.68542 1.000 12.60852 ? 335  ARG   A O   1 
ATOM   2521 C CB  . ARG   A 1 353 ? -23.13752 12.16222  -27.73184 1.000 19.89356 ? 335  ARG   A CB  1 
ATOM   2522 C CG  . ARG   A 1 353 ? -23.11701 13.67378  -27.58042 1.000 33.16780 ? 335  ARG   A CG  1 
ATOM   2523 C CD  . ARG   A 1 353 ? -23.66822 14.42745  -28.78489 1.000 35.92752 ? 335  ARG   A CD  1 
ATOM   2524 N NE  . ARG   A 1 353 ? -23.74580 15.86245  -28.52411 1.000 28.57958 ? 335  ARG   A NE  1 
ATOM   2525 C CZ  . ARG   A 1 353 ? -23.10866 16.77957  -29.23809 1.000 37.25232 ? 335  ARG   A CZ  1 
ATOM   2526 N NH1 . ARG   A 1 353 ? -22.31313 16.44220  -30.24016 1.000 31.05483 ? 335  ARG   A NH1 1 
ATOM   2527 N NH2 . ARG   A 1 353 ? -23.27571 18.06663  -28.94196 1.000 39.74473 ? 335  ARG   A NH2 1 
ATOM   2528 N N   . GLU   A 1 354 ? -22.39491 9.19004   -27.90370 1.000 17.79108 ? 336  GLU   A N   1 
ATOM   2529 C CA  . GLU   A 1 354 ? -22.81652 7.79763   -27.80975 1.000 15.36751 ? 336  GLU   A CA  1 
ATOM   2530 C C   . GLU   A 1 354 ? -21.80192 6.94118   -27.06069 1.000 12.99348 ? 336  GLU   A C   1 
ATOM   2531 O O   . GLU   A 1 354 ? -22.18353 6.01166   -26.33475 1.000 13.55373 ? 336  GLU   A O   1 
ATOM   2532 C CB  . GLU   A 1 354 ? -23.06217 7.25037   -29.21570 1.000 14.41222 ? 336  GLU   A CB  1 
ATOM   2533 C CG  . GLU   A 1 354 ? -24.23096 7.94308   -29.90432 1.000 21.75553 ? 336  GLU   A CG  1 
ATOM   2534 C CD  . GLU   A 1 354 ? -23.81167 9.14475   -30.74621 1.000 36.48577 ? 336  GLU   A CD  1 
ATOM   2535 O OE1 . GLU   A 1 354 ? -22.72734 9.73625   -30.49836 1.000 20.81829 ? 336  GLU   A OE1 1 
ATOM   2536 O OE2 . GLU   A 1 354 ? -24.59618 9.52075   -31.64812 1.000 43.43210 ? 336  GLU   A OE2 1 
ATOM   2537 N N   . ALA   A 1 355 ? -20.50751 7.21423   -27.23689 1.000 15.66109 ? 337  ALA   A N   1 
ATOM   2538 C CA  . ALA   A 1 355 ? -19.49698 6.47659   -26.47887 1.000 13.59555 ? 337  ALA   A CA  1 
ATOM   2539 C C   . ALA   A 1 355 ? -19.64479 6.73333   -24.98235 1.000 15.96683 ? 337  ALA   A C   1 
ATOM   2540 O O   . ALA   A 1 355 ? -19.62707 5.79771   -24.16702 1.000 14.41376 ? 337  ALA   A O   1 
ATOM   2541 C CB  . ALA   A 1 355 ? -18.09818 6.86204   -26.95378 1.000 11.36971 ? 337  ALA   A CB  1 
ATOM   2542 N N   . LEU   A 1 356 ? -19.78009 8.00588   -24.60157 1.000 13.26855 ? 338  LEU   A N   1 
ATOM   2543 C CA  . LEU   A 1 356 ? -19.88022 8.34630   -23.18427 1.000 13.80582 ? 338  LEU   A CA  1 
ATOM   2544 C C   . LEU   A 1 356 ? -21.14841 7.77023   -22.56720 1.000 16.69246 ? 338  LEU   A C   1 
ATOM   2545 O O   . LEU   A 1 356 ? -21.14682 7.33741   -21.40482 1.000 16.34962 ? 338  LEU   A O   1 
ATOM   2546 C CB  . LEU   A 1 356 ? -19.83927 9.86304   -23.00858 1.000 13.08605 ? 338  LEU   A CB  1 
ATOM   2547 C CG  . LEU   A 1 356 ? -18.46122 10.49634  -23.20636 1.000 15.63932 ? 338  LEU   A CG  1 
ATOM   2548 C CD1 . LEU   A 1 356 ? -18.56877 12.01024  -23.17728 1.000 16.82092 ? 338  LEU   A CD1 1 
ATOM   2549 C CD2 . LEU   A 1 356 ? -17.50860 9.99467   -22.13244 1.000 13.85611 ? 338  LEU   A CD2 1 
ATOM   2550 N N   . GLN   A 1 357 ? -22.24587 7.76216   -23.32325 1.000 11.81369 ? 339  GLN   A N   1 
ATOM   2551 C CA  . GLN   A 1 357 ? -23.47408 7.18514   -22.79190 1.000 19.46700 ? 339  GLN   A CA  1 
ATOM   2552 C C   . GLN   A 1 357 ? -23.34123 5.67515   -22.62082 1.000 18.27051 ? 339  GLN   A C   1 
ATOM   2553 O O   . GLN   A 1 357 ? -23.85598 5.10882   -21.64959 1.000 14.05497 ? 339  GLN   A O   1 
ATOM   2554 C CB  . GLN   A 1 357 ? -24.65636 7.52880   -23.69513 1.000 12.22926 ? 339  GLN   A CB  1 
ATOM   2555 C CG  . GLN   A 1 357 ? -25.95160 6.86489   -23.27986 1.000 20.15984 ? 339  GLN   A CG  1 
ATOM   2556 C CD  . GLN   A 1 357 ? -27.11211 7.36437   -24.09582 1.000 36.79574 ? 339  GLN   A CD  1 
ATOM   2557 O OE1 . GLN   A 1 357 ? -28.11161 7.84302   -23.54938 1.000 35.67235 ? 339  GLN   A OE1 1 
ATOM   2558 N NE2 . GLN   A 1 357 ? -26.98835 7.27247   -25.41431 1.000 38.70056 ? 339  GLN   A NE2 1 
ATOM   2559 N N   . ALA   A 1 358 ? -22.64968 5.00511   -23.54484 1.000 11.75815 ? 340  ALA   A N   1 
ATOM   2560 C CA  . ALA   A 1 358 ? -22.48196 3.55835   -23.41958 1.000 16.05654 ? 340  ALA   A CA  1 
ATOM   2561 C C   . ALA   A 1 358 ? -21.55398 3.20018   -22.25686 1.000 12.79715 ? 340  ALA   A C   1 
ATOM   2562 O O   . ALA   A 1 358 ? -21.76863 2.18792   -21.57703 1.000 15.98275 ? 340  ALA   A O   1 
ATOM   2563 C CB  . ALA   A 1 358 ? -21.96633 2.97200   -24.73632 1.000 11.64878 ? 340  ALA   A CB  1 
ATOM   2564 N N   . TRP   A 1 359 ? -20.52415 4.01877   -22.00307 1.000 10.79450 ? 341  TRP   A N   1 
ATOM   2565 C CA  . TRP   A 1 359 ? -19.68926 3.79053   -20.82911 1.000 16.06342 ? 341  TRP   A CA  1 
ATOM   2566 C C   . TRP   A 1 359 ? -20.44495 4.08176   -19.54423 1.000 12.35336 ? 341  TRP   A C   1 
ATOM   2567 O O   . TRP   A 1 359 ? -20.28337 3.36441   -18.55243 1.000 14.25307 ? 341  TRP   A O   1 
ATOM   2568 C CB  . TRP   A 1 359 ? -18.42464 4.63385   -20.90203 1.000 15.12770 ? 341  TRP   A CB  1 
ATOM   2569 C CG  . TRP   A 1 359 ? -17.42803 4.00579   -21.75969 1.000 18.07698 ? 341  TRP   A CG  1 
ATOM   2570 C CD1 . TRP   A 1 359 ? -17.11635 2.67315   -21.82030 1.000 12.53675 ? 341  TRP   A CD1 1 
ATOM   2571 C CD2 . TRP   A 1 359 ? -16.63380 4.65228   -22.73407 1.000 15.46988 ? 341  TRP   A CD2 1 
ATOM   2572 N NE1 . TRP   A 1 359 ? -16.14426 2.46432   -22.75748 1.000 24.78507 ? 341  TRP   A NE1 1 
ATOM   2573 C CE2 . TRP   A 1 359 ? -15.83676 3.66460   -23.34250 1.000 16.44345 ? 341  TRP   A CE2 1 
ATOM   2574 C CE3 . TRP   A 1 359 ? -16.50939 5.97950   -23.15407 1.000 18.96877 ? 341  TRP   A CE3 1 
ATOM   2575 C CZ2 . TRP   A 1 359 ? -14.92399 3.96241   -24.34578 1.000 26.29080 ? 341  TRP   A CZ2 1 
ATOM   2576 C CZ3 . TRP   A 1 359 ? -15.60762 6.27172   -24.15133 1.000 28.69764 ? 341  TRP   A CZ3 1 
ATOM   2577 C CH2 . TRP   A 1 359 ? -14.82667 5.27034   -24.73785 1.000 28.59297 ? 341  TRP   A CH2 1 
ATOM   2578 N N   . ALA   A 1 360 ? -21.27228 5.12709   -19.53704 1.000 15.11048 ? 342  ALA   A N   1 
ATOM   2579 C CA  . ALA   A 1 360 ? -22.13217 5.35938   -18.38187 1.000 17.67844 ? 342  ALA   A CA  1 
ATOM   2580 C C   . ALA   A 1 360 ? -23.06317 4.17354   -18.14710 1.000 20.68738 ? 342  ALA   A C   1 
ATOM   2581 O O   . ALA   A 1 360 ? -23.26000 3.74418   -17.00444 1.000 17.37304 ? 342  ALA   A O   1 
ATOM   2582 C CB  . ALA   A 1 360 ? -22.92865 6.65264   -18.57372 1.000 15.73410 ? 342  ALA   A CB  1 
ATOM   2583 N N   . ASP   A 1 361 ? -23.64458 3.62763   -19.22046 1.000 15.18492 ? 343  ASP   A N   1 
ATOM   2584 C CA  . ASP   A 1 361 ? -24.45447 2.41896   -19.09124 1.000 16.12155 ? 343  ASP   A CA  1 
ATOM   2585 C C   . ASP   A 1 361 ? -23.63398 1.25200   -18.55949 1.000 12.98624 ? 343  ASP   A C   1 
ATOM   2586 O O   . ASP   A 1 361 ? -24.16140 0.41459   -17.81932 1.000 13.51427 ? 343  ASP   A O   1 
ATOM   2587 C CB  . ASP   A 1 361 ? -25.06587 2.04018   -20.44108 1.000 15.49635 ? 343  ASP   A CB  1 
ATOM   2588 C CG  . ASP   A 1 361 ? -26.18463 2.98161   -20.86468 1.000 27.38323 ? 343  ASP   A CG  1 
ATOM   2589 O OD1 . ASP   A 1 361 ? -26.64163 3.78824   -20.02046 1.000 21.78738 ? 343  ASP   A OD1 1 
ATOM   2590 O OD2 . ASP   A 1 361 ? -26.59073 2.91924   -22.04700 1.000 23.81275 ? 343  ASP   A OD2 1 
ATOM   2591 N N   . THR   A 1 362 ? -22.35265 1.17697   -18.94014 1.000 14.28820 ? 344  THR   A N   1 
ATOM   2592 C CA  . THR   A 1 362 ? -21.46772 0.12792   -18.43607 1.000 10.73327 ? 344  THR   A CA  1 
ATOM   2593 C C   . THR   A 1 362 ? -21.30252 0.23470   -16.92710 1.000 14.21068 ? 344  THR   A C   1 
ATOM   2594 O O   . THR   A 1 362 ? -21.43635 -0.75910  -16.19934 1.000 16.86485 ? 344  THR   A O   1 
ATOM   2595 C CB  . THR   A 1 362 ? -20.09752 0.21056   -19.12180 1.000 14.93567 ? 344  THR   A CB  1 
ATOM   2596 O OG1 . THR   A 1 362 ? -20.25601 0.23282   -20.54401 1.000 16.27376 ? 344  THR   A OG1 1 
ATOM   2597 C CG2 . THR   A 1 362 ? -19.22313 -0.98633  -18.74258 1.000 16.23629 ? 344  THR   A CG2 1 
ATOM   2598 N N   . ALA   A 1 363 ? -21.01000 1.44088   -16.43831 1.000 16.09191 ? 345  ALA   A N   1 
ATOM   2599 C CA  . ALA   A 1 363 ? -20.83208 1.63635   -15.00285 1.000 16.37106 ? 345  ALA   A CA  1 
ATOM   2600 C C   . ALA   A 1 363 ? -22.12667 1.40980   -14.24038 1.000 13.51883 ? 345  ALA   A C   1 
ATOM   2601 O O   . ALA   A 1 363 ? -22.09370 1.05982   -13.05821 1.000 13.08315 ? 345  ALA   A O   1 
ATOM   2602 C CB  . ALA   A 1 363 ? -20.30066 3.03944   -14.72359 1.000 14.06919 ? 345  ALA   A CB  1 
ATOM   2603 N N   . THR   A 1 364 ? -23.27003 1.62927   -14.88562 1.000 13.41658 ? 346  THR   A N   1 
ATOM   2604 C CA  . THR   A 1 364 ? -24.54621 1.39541   -14.21952 1.000 13.18656 ? 346  THR   A CA  1 
ATOM   2605 C C   . THR   A 1 364 ? -24.77504 -0.09220  -13.95279 1.000 17.68124 ? 346  THR   A C   1 
ATOM   2606 O O   . THR   A 1 364 ? -25.46054 -0.44642  -12.98875 1.000 16.54896 ? 346  THR   A O   1 
ATOM   2607 C CB  . THR   A 1 364 ? -25.67538 1.99876   -15.06854 1.000 22.82188 ? 346  THR   A CB  1 
ATOM   2608 O OG1 . THR   A 1 364 ? -25.51377 3.42182   -15.12811 1.000 18.70122 ? 346  THR   A OG1 1 
ATOM   2609 C CG2 . THR   A 1 364 ? -27.03801 1.70085   -14.48174 1.000 25.72363 ? 346  THR   A CG2 1 
ATOM   2610 N N   . VAL   A 1 365 ? -24.20864 -0.98022  -14.77442 1.000 18.12894 ? 347  VAL   A N   1 
ATOM   2611 C CA  . VAL   A 1 365 ? -24.34406 -2.41240  -14.48801 1.000 18.18363 ? 347  VAL   A CA  1 
ATOM   2612 C C   . VAL   A 1 365 ? -23.37646 -2.83321  -13.38545 1.000 15.73357 ? 347  VAL   A C   1 
ATOM   2613 O O   . VAL   A 1 365 ? -23.74310 -3.59376  -12.47657 1.000 11.94368 ? 347  VAL   A O   1 
ATOM   2614 C CB  . VAL   A 1 365 ? -24.14539 -3.26081  -15.76439 1.000 15.62877 ? 347  VAL   A CB  1 
ATOM   2615 C CG1 . VAL   A 1 365 ? -24.27608 -4.75554  -15.43170 1.000 16.64076 ? 347  VAL   A CG1 1 
ATOM   2616 C CG2 . VAL   A 1 365 ? -25.15973 -2.89077  -16.83537 1.000 15.03947 ? 347  VAL   A CG2 1 
ATOM   2617 N N   . ILE   A 1 366 ? -22.13382 -2.33795  -13.43242 1.000 11.79873 ? 348  ILE   A N   1 
ATOM   2618 C CA  . ILE   A 1 366 ? -21.14308 -2.76475  -12.44908 1.000 13.51934 ? 348  ILE   A CA  1 
ATOM   2619 C C   . ILE   A 1 366 ? -21.46672 -2.24762  -11.05319 1.000 13.67859 ? 348  ILE   A C   1 
ATOM   2620 O O   . ILE   A 1 366 ? -21.05704 -2.85775  -10.05906 1.000 16.32647 ? 348  ILE   A O   1 
ATOM   2621 C CB  . ILE   A 1 366 ? -19.72471 -2.33378  -12.87381 1.000 13.00552 ? 348  ILE   A CB  1 
ATOM   2622 C CG1 . ILE   A 1 366 ? -18.67582 -3.17306  -12.14260 1.000 10.62708 ? 348  ILE   A CG1 1 
ATOM   2623 C CG2 . ILE   A 1 366 ? -19.46862 -0.86996  -12.55481 1.000 14.66057 ? 348  ILE   A CG2 1 
ATOM   2624 C CD1 . ILE   A 1 366 ? -18.63597 -4.63934  -12.60223 1.000 10.81655 ? 348  ILE   A CD1 1 
ATOM   2625 N N   . GLN   A 1 367 ? -22.22399 -1.15780  -10.93994 1.000 13.32013 ? 349  GLN   A N   1 
ATOM   2626 C CA  . GLN   A 1 367 ? -22.39849 -0.52439  -9.63486  1.000 13.84948 ? 349  GLN   A CA  1 
ATOM   2627 C C   . GLN   A 1 367 ? -23.12297 -1.41956  -8.63592  1.000 21.55833 ? 349  GLN   A C   1 
ATOM   2628 O O   . GLN   A 1 367 ? -23.00451 -1.19852  -7.42219  1.000 14.08282 ? 349  GLN   A O   1 
ATOM   2629 C CB  . GLN   A 1 367 ? -23.12656 0.80681   -9.81951  1.000 14.03243 ? 349  GLN   A CB  1 
ATOM   2630 C CG  . GLN   A 1 367 ? -24.62345 0.69758   -9.98101  1.000 10.11266 ? 349  GLN   A CG  1 
ATOM   2631 C CD  . GLN   A 1 367 ? -25.28740 2.06601   -10.10305 1.000 25.58912 ? 349  GLN   A CD  1 
ATOM   2632 O OE1 . GLN   A 1 367 ? -24.60620 3.08547   -10.21556 1.000 32.93501 ? 349  GLN   A OE1 1 
ATOM   2633 N NE2 . GLN   A 1 367 ? -26.61800 2.09138   -10.08946 1.000 24.19881 ? 349  GLN   A NE2 1 
ATOM   2634 N N   . ASP   A 1 368 ? -23.83140 -2.44449  -9.11402  1.000 15.26566 ? 350  ASP   A N   1 
ATOM   2635 C CA  . ASP   A 1 368 ? -24.57955 -3.36116  -8.26896  1.000 16.38531 ? 350  ASP   A CA  1 
ATOM   2636 C C   . ASP   A 1 368 ? -23.79945 -4.62387  -7.91966  1.000 19.72906 ? 350  ASP   A C   1 
ATOM   2637 O O   . ASP   A 1 368 ? -24.35542 -5.52407  -7.28364  1.000 25.11031 ? 350  ASP   A O   1 
ATOM   2638 C CB  . ASP   A 1 368 ? -25.89432 -3.73155  -8.95585  1.000 18.26480 ? 350  ASP   A CB  1 
ATOM   2639 C CG  . ASP   A 1 368 ? -26.85561 -2.56016  -9.03173  1.000 28.65784 ? 350  ASP   A CG  1 
ATOM   2640 O OD1 . ASP   A 1 368 ? -26.80448 -1.68724  -8.13902  1.000 24.48236 ? 350  ASP   A OD1 1 
ATOM   2641 O OD2 . ASP   A 1 368 ? -27.66236 -2.51323  -9.98394  1.000 28.48334 ? 350  ASP   A OD2 1 
ATOM   2642 N N   . TYR   A 1 369 ? -22.53781 -4.71064  -8.32529  1.000 15.15241 ? 351  TYR   A N   1 
ATOM   2643 C CA  . TYR   A 1 369 ? -21.62986 -5.79254  -7.97697  1.000 14.52124 ? 351  TYR   A CA  1 
ATOM   2644 C C   . TYR   A 1 369 ? -20.75706 -5.38568  -6.79656  1.000 16.36403 ? 351  TYR   A C   1 
ATOM   2645 O O   . TYR   A 1 369 ? -20.59758 -4.20029  -6.49354  1.000 16.15041 ? 351  TYR   A O   1 
ATOM   2646 C CB  . TYR   A 1 369 ? -20.73347 -6.14346  -9.17207  1.000 12.93648 ? 351  TYR   A CB  1 
ATOM   2647 C CG  . TYR   A 1 369 ? -21.38506 -7.03282  -10.20821 1.000 13.30426 ? 351  TYR   A CG  1 
ATOM   2648 C CD1 . TYR   A 1 369 ? -21.37570 -8.42007  -10.05829 1.000 14.74747 ? 351  TYR   A CD1 1 
ATOM   2649 C CD2 . TYR   A 1 369 ? -22.01129 -6.49698  -11.32563 1.000 12.78460 ? 351  TYR   A CD2 1 
ATOM   2650 C CE1 . TYR   A 1 369 ? -21.95845 -9.24925  -10.98843 1.000 13.74222 ? 351  TYR   A CE1 1 
ATOM   2651 C CE2 . TYR   A 1 369 ? -22.61842 -7.32744  -12.27091 1.000 16.41756 ? 351  TYR   A CE2 1 
ATOM   2652 C CZ  . TYR   A 1 369 ? -22.57971 -8.70137  -12.09282 1.000 15.97779 ? 351  TYR   A CZ  1 
ATOM   2653 O OH  . TYR   A 1 369 ? -23.15395 -9.54118  -13.01785 1.000 15.36201 ? 351  TYR   A OH  1 
ATOM   2654 N N   . ASN   A 1 370 ? -20.16919 -6.38348  -6.14085  1.000 20.34243 ? 352  ASN   A N   1 
ATOM   2655 C CA  . ASN   A 1 370 ? -19.12462 -6.14916  -5.14833  1.000 20.83703 ? 352  ASN   A CA  1 
ATOM   2656 C C   . ASN   A 1 370 ? -17.77781 -6.48252  -5.76551  1.000 19.54024 ? 352  ASN   A C   1 
ATOM   2657 O O   . ASN   A 1 370 ? -17.59709 -7.58321  -6.29955  1.000 18.91749 ? 352  ASN   A O   1 
ATOM   2658 C CB  . ASN   A 1 370 ? -19.33909 -6.98731  -3.88824  1.000 25.24605 ? 352  ASN   A CB  1 
ATOM   2659 C CG  . ASN   A 1 370 ? -20.60410 -6.61773  -3.16034  1.000 34.21766 ? 352  ASN   A CG  1 
ATOM   2660 O OD1 . ASN   A 1 370 ? -20.99375 -5.44855  -3.13066  1.000 31.07443 ? 352  ASN   A OD1 1 
ATOM   2661 N ND2 . ASN   A 1 370 ? -21.25898 -7.61171  -2.56757  1.000 31.58366 ? 352  ASN   A ND2 1 
ATOM   2662 N N   . TYR   A 1 371 ? -16.84261 -5.53142  -5.70702  1.000 14.11976 ? 353  TYR   A N   1 
ATOM   2663 C CA  . TYR   A 1 371 ? -15.52736 -5.74623  -6.29328  1.000 15.57316 ? 353  TYR   A CA  1 
ATOM   2664 C C   . TYR   A 1 371 ? -14.75815 -6.73400  -5.42673  1.000 20.89975 ? 353  TYR   A C   1 
ATOM   2665 O O   . TYR   A 1 371 ? -14.40543 -6.43066  -4.28242  1.000 19.03959 ? 353  TYR   A O   1 
ATOM   2666 C CB  . TYR   A 1 371 ? -14.75750 -4.43415  -6.44106  1.000 13.99277 ? 353  TYR   A CB  1 
ATOM   2667 C CG  . TYR   A 1 371 ? -13.40707 -4.63593  -7.10910  1.000 15.05923 ? 353  TYR   A CG  1 
ATOM   2668 C CD1 . TYR   A 1 371 ? -13.28505 -5.45086  -8.23421  1.000 16.12376 ? 353  TYR   A CD1 1 
ATOM   2669 C CD2 . TYR   A 1 371 ? -12.25288 -4.04239  -6.61029  1.000 23.28231 ? 353  TYR   A CD2 1 
ATOM   2670 C CE1 . TYR   A 1 371 ? -12.05939 -5.65135  -8.85039  1.000 17.86016 ? 353  TYR   A CE1 1 
ATOM   2671 C CE2 . TYR   A 1 371 ? -11.01725 -4.24184  -7.22557  1.000 18.09565 ? 353  TYR   A CE2 1 
ATOM   2672 C CZ  . TYR   A 1 371 ? -10.93335 -5.04760  -8.34747  1.000 21.03360 ? 353  TYR   A CZ  1 
ATOM   2673 O OH  . TYR   A 1 371 ? -9.72005  -5.27487  -8.97065  1.000 21.97279 ? 353  TYR   A OH  1 
ATOM   2674 N N   . CYS   A 1 372 ? -14.49951 -7.91421  -5.96983  1.000 19.92301 ? 354  CYS   A N   1 
ATOM   2675 C CA  . CYS   A 1 372 ? -13.86134 -8.99501  -5.23843  1.000 26.47030 ? 354  CYS   A CA  1 
ATOM   2676 C C   . CYS   A 1 372 ? -12.48817 -9.27904  -5.83999  1.000 25.17318 ? 354  CYS   A C   1 
ATOM   2677 O O   . CYS   A 1 372 ? -12.12510 -8.76813  -6.90322  1.000 23.23803 ? 354  CYS   A O   1 
ATOM   2678 C CB  . CYS   A 1 372 ? -14.75419 -10.24231 -5.25879  1.000 30.14197 ? 354  CYS   A CB  1 
ATOM   2679 S SG  . CYS   A 1 372 ? -16.33427 -10.03473 -4.33736  1.000 27.11496 ? 354  CYS   A SG  1 
ATOM   2680 N N   . ARG   A 1 373 ? -11.72489 -10.12440 -5.14849  1.000 34.19604 ? 355  ARG   A N   1 
ATOM   2681 C CA  . ARG   A 1 373 ? -10.30942 -10.28659 -5.47410  1.000 44.70026 ? 355  ARG   A CA  1 
ATOM   2682 C C   . ARG   A 1 373 ? -10.09657 -10.87063 -6.86872  1.000 29.63349 ? 355  ARG   A C   1 
ATOM   2683 O O   . ARG   A 1 373 ? -9.12516  -10.51327 -7.54481  1.000 40.14125 ? 355  ARG   A O   1 
ATOM   2684 C CB  . ARG   A 1 373 ? -9.61512  -11.15733 -4.41758  1.000 51.29213 ? 355  ARG   A CB  1 
ATOM   2685 C CG  . ARG   A 1 373 ? -9.53406  -10.55790 -2.99908  1.000 62.57593 ? 355  ARG   A CG  1 
ATOM   2686 C CD  . ARG   A 1 373 ? -10.88010 -10.51739 -2.28649  1.000 62.05426 ? 355  ARG   A CD  1 
ATOM   2687 N NE  . ARG   A 1 373 ? -11.69747 -11.68020 -2.61467  1.000 68.32082 ? 355  ARG   A NE  1 
ATOM   2688 C CZ  . ARG   A 1 373 ? -12.98874 -11.78572 -2.33242  1.000 55.18323 ? 355  ARG   A CZ  1 
ATOM   2689 N NH1 . ARG   A 1 373 ? -13.64337 -10.80724 -1.73261  1.000 35.24755 ? 355  ARG   A NH1 1 
ATOM   2690 N NH2 . ARG   A 1 373 ? -13.64086 -12.89726 -2.67040  1.000 66.80828 ? 355  ARG   A NH2 1 
ATOM   2691 N N   . GLU   A 1 374 ? -10.98833 -11.74506 -7.32689  1.000 28.57109 ? 356  GLU   A N   1 
ATOM   2692 C CA  . GLU   A 1 374 ? -10.82170 -12.39533 -8.61920  1.000 25.60100 ? 356  GLU   A CA  1 
ATOM   2693 C C   . GLU   A 1 374 ? -11.42050 -11.59142 -9.77168  1.000 19.86018 ? 356  GLU   A C   1 
ATOM   2694 O O   . GLU   A 1 374 ? -11.54295 -12.12393 -10.87865 1.000 17.10105 ? 356  GLU   A O   1 
ATOM   2695 C CB  . GLU   A 1 374 ? -11.45937 -13.79247 -8.61411  1.000 23.44286 ? 356  GLU   A CB  1 
ATOM   2696 C CG  . GLU   A 1 374 ? -10.98655 -14.76005 -7.52834  1.000 43.31205 ? 356  GLU   A CG  1 
ATOM   2697 C CD  . GLU   A 1 374 ? -12.15225 -15.30395 -6.69458  1.000 61.46002 ? 356  GLU   A CD  1 
ATOM   2698 O OE1 . GLU   A 1 374 ? -12.14223 -16.51371 -6.36385  1.000 56.46682 ? 356  GLU   A OE1 1 
ATOM   2699 O OE2 . GLU   A 1 374 ? -13.08551 -14.52515 -6.38061  1.000 51.05414 ? 356  GLU   A OE2 1 
ATOM   2700 N N   . ASP   A 1 375 ? -11.81947 -10.34284 -9.54302  1.000 19.55971 ? 357  ASP   A N   1 
ATOM   2701 C CA  . ASP   A 1 375 ? -12.47006 -9.55200  -10.58122 1.000 22.70429 ? 357  ASP   A CA  1 
ATOM   2702 C C   . ASP   A 1 375 ? -11.49470 -8.67831  -11.35583 1.000 21.96786 ? 357  ASP   A C   1 
ATOM   2703 O O   . ASP   A 1 375 ? -11.93755 -7.74910  -12.03997 1.000 12.03944 ? 357  ASP   A O   1 
ATOM   2704 C CB  . ASP   A 1 375 ? -13.57254 -8.67172  -9.97821  1.000 17.95880 ? 357  ASP   A CB  1 
ATOM   2705 C CG  . ASP   A 1 375 ? -14.76259 -9.46906  -9.48574  1.000 19.46415 ? 357  ASP   A CG  1 
ATOM   2706 O OD1 . ASP   A 1 375 ? -14.95746 -10.61852 -9.93620  1.000 19.08095 ? 357  ASP   A OD1 1 
ATOM   2707 O OD2 . ASP   A 1 375 ? -15.50772 -8.93823  -8.63560  1.000 18.40855 ? 357  ASP   A OD2 1 
ATOM   2708 N N   . GLU   A 1 376 ? -10.18556 -8.97676  -11.28896 1.000 12.22311 ? 358  GLU   A N   1 
ATOM   2709 C CA  . GLU   A 1 376 ? -9.16645  -8.06409  -11.79450 1.000 16.83844 ? 358  GLU   A CA  1 
ATOM   2710 C C   . GLU   A 1 376 ? -9.33708  -7.72926  -13.27274 1.000 16.81996 ? 358  GLU   A C   1 
ATOM   2711 O O   . GLU   A 1 376 ? -8.95909  -6.63167  -13.69663 1.000 16.36015 ? 358  GLU   A O   1 
ATOM   2712 C CB  . GLU   A 1 376 ? -7.77492  -8.66068  -11.57658 1.000 23.19918 ? 358  GLU   A CB  1 
ATOM   2713 C CG  . GLU   A 1 376 ? -7.07134  -8.16977  -10.33644 1.000 35.39172 ? 358  GLU   A CG  1 
ATOM   2714 C CD  . GLU   A 1 376 ? -5.92131  -9.08070  -9.94941  1.000 33.63581 ? 358  GLU   A CD  1 
ATOM   2715 O OE1 . GLU   A 1 376 ? -5.42954  -9.81314  -10.83347 1.000 41.91950 ? 358  GLU   A OE1 1 
ATOM   2716 O OE2 . GLU   A 1 376 ? -5.53082  -9.08530  -8.76393  1.000 46.02115 ? 358  GLU   A OE2 1 
ATOM   2717 N N   . GLU   A 1 377 ? -9.85335  -8.65968  -14.07972 1.000 14.39191 ? 359  GLU   A N   1 
ATOM   2718 C CA  . GLU   A 1 377 ? -9.93999  -8.42958  -15.52382 1.000 17.45253 ? 359  GLU   A CA  1 
ATOM   2719 C C   . GLU   A 1 377 ? -10.89519 -7.28564  -15.85561 1.000 18.29701 ? 359  GLU   A C   1 
ATOM   2720 O O   . GLU   A 1 377 ? -10.57260 -6.41380  -16.67399 1.000 15.27156 ? 359  GLU   A O   1 
ATOM   2721 C CB  . GLU   A 1 377 ? -10.37596 -9.71136  -16.23247 1.000 19.01639 ? 359  GLU   A CB  1 
ATOM   2722 C CG  . GLU   A 1 377 ? -10.30700 -9.68400  -17.76045 1.000 18.87387 ? 359  GLU   A CG  1 
ATOM   2723 C CD  . GLU   A 1 377 ? -8.89925  -9.48749  -18.34453 1.000 29.87225 ? 359  GLU   A CD  1 
ATOM   2724 O OE1 . GLU   A 1 377 ? -7.87463  -9.65270  -17.63556 1.000 22.56613 ? 359  GLU   A OE1 1 
ATOM   2725 O OE2 . GLU   A 1 377 ? -8.82730  -9.18438  -19.55198 1.000 27.92445 ? 359  GLU   A OE2 1 
ATOM   2726 N N   . ILE   A 1 378 ? -12.08652 -7.27703  -15.24795 1.000 12.39371 ? 360  ILE   A N   1 
ATOM   2727 C CA  . ILE   A 1 378 ? -13.00073 -6.16932  -15.52128 1.000 12.76603 ? 360  ILE   A CA  1 
ATOM   2728 C C   . ILE   A 1 378 ? -12.46649 -4.87313  -14.91760 1.000 13.58695 ? 360  ILE   A C   1 
ATOM   2729 O O   . ILE   A 1 378 ? -12.68700 -3.78707  -15.47506 1.000 11.78957 ? 360  ILE   A O   1 
ATOM   2730 C CB  . ILE   A 1 378 ? -14.43331 -6.48942  -15.03769 1.000 13.38003 ? 360  ILE   A CB  1 
ATOM   2731 C CG1 . ILE   A 1 378 ? -15.44582 -5.66695  -15.84028 1.000 12.38056 ? 360  ILE   A CG1 1 
ATOM   2732 C CG2 . ILE   A 1 378 ? -14.61502 -6.23751  -13.54020 1.000 13.92837 ? 360  ILE   A CG2 1 
ATOM   2733 C CD1 . ILE   A 1 378 ? -15.37794 -5.92131  -17.33108 1.000 13.11236 ? 360  ILE   A CD1 1 
ATOM   2734 N N   . TYR   A 1 379 ? -11.74973 -4.95846  -13.78781 1.000 13.63383 ? 361  TYR   A N   1 
ATOM   2735 C CA  . TYR   A 1 379 ? -11.07087 -3.78436  -13.24633 1.000 10.43721 ? 361  TYR   A CA  1 
ATOM   2736 C C   . TYR   A 1 379 ? -10.09345 -3.19517  -14.25774 1.000 16.66168 ? 361  TYR   A C   1 
ATOM   2737 O O   . TYR   A 1 379 ? -10.06228 -1.97623  -14.45774 1.000 12.00841 ? 361  TYR   A O   1 
ATOM   2738 C CB  . TYR   A 1 379 ? -10.34249 -4.13239  -11.94405 1.000 14.38837 ? 361  TYR   A CB  1 
ATOM   2739 C CG  . TYR   A 1 379 ? -9.57284  -2.96829  -11.34489 1.000 16.23985 ? 361  TYR   A CG  1 
ATOM   2740 C CD1 . TYR   A 1 379 ? -10.19700 -2.06324  -10.49560 1.000 14.45007 ? 361  TYR   A CD1 1 
ATOM   2741 C CD2 . TYR   A 1 379 ? -8.22282  -2.77253  -11.62961 1.000 16.10928 ? 361  TYR   A CD2 1 
ATOM   2742 C CE1 . TYR   A 1 379 ? -9.50706  -0.99970  -9.94092  1.000 14.28899 ? 361  TYR   A CE1 1 
ATOM   2743 C CE2 . TYR   A 1 379 ? -7.52457  -1.70434  -11.08078 1.000 22.93085 ? 361  TYR   A CE2 1 
ATOM   2744 C CZ  . TYR   A 1 379 ? -8.18021  -0.82355  -10.23593 1.000 16.43557 ? 361  TYR   A CZ  1 
ATOM   2745 O OH  . TYR   A 1 379 ? -7.50951  0.23429   -9.67835  1.000 15.75706 ? 361  TYR   A OH  1 
ATOM   2746 N N   . LYS   A 1 380 ? -9.26306  -4.03985  -14.89264 1.000 15.54022 ? 362  LYS   A N   1 
ATOM   2747 C CA  . LYS   A 1 380 ? -8.33512  -3.50400  -15.88977 1.000 10.77189 ? 362  LYS   A CA  1 
ATOM   2748 C C   . LYS   A 1 380 ? -9.05445  -2.86346  -17.07037 1.000 13.86683 ? 362  LYS   A C   1 
ATOM   2749 O O   . LYS   A 1 380 ? -8.57836  -1.84894  -17.60094 1.000 14.21733 ? 362  LYS   A O   1 
ATOM   2750 C CB  . LYS   A 1 380 ? -7.33549  -4.57208  -16.36135 1.000 17.63249 ? 362  LYS   A CB  1 
ATOM   2751 C CG  . LYS   A 1 380 ? -6.77324  -5.41011  -15.21174 1.000 37.63635 ? 362  LYS   A CG  1 
ATOM   2752 C CD  . LYS   A 1 380 ? -5.87701  -6.56095  -15.65236 1.000 41.42769 ? 362  LYS   A CD  1 
ATOM   2753 C CE  . LYS   A 1 380 ? -5.24611  -7.24082  -14.43495 1.000 27.74761 ? 362  LYS   A CE  1 
ATOM   2754 N NZ  . LYS   A 1 380 ? -4.13806  -8.16350  -14.79390 1.000 37.63496 ? 362  LYS   A NZ  1 
ATOM   2755 N N   . GLU   A 1 381 ? -10.21555 -3.38778  -17.46900 1.000 12.67283 ? 363  GLU   A N   1 
ATOM   2756 C CA  . GLU   A 1 381 ? -10.93796 -2.74672  -18.56286 1.000 12.19752 ? 363  GLU   A CA  1 
ATOM   2757 C C   . GLU   A 1 381 ? -11.47055 -1.37894  -18.14539 1.000 10.34974 ? 363  GLU   A C   1 
ATOM   2758 O O   . GLU   A 1 381 ? -11.38488 -0.41815  -18.91713 1.000 13.61469 ? 363  GLU   A O   1 
ATOM   2759 C CB  . GLU   A 1 381 ? -12.07529 -3.64200  -19.05507 1.000 16.57514 ? 363  GLU   A CB  1 
ATOM   2760 C CG  . GLU   A 1 381 ? -11.63215 -4.92033  -19.77637 1.000 20.92603 ? 363  GLU   A CG  1 
ATOM   2761 C CD  . GLU   A 1 381 ? -10.78158 -4.68239  -21.02720 1.000 20.55708 ? 363  GLU   A CD  1 
ATOM   2762 O OE1 . GLU   A 1 381 ? -10.74966 -3.55035  -21.56690 1.000 21.49655 ? 363  GLU   A OE1 1 
ATOM   2763 O OE2 . GLU   A 1 381 ? -10.15694 -5.65924  -21.49134 1.000 35.29726 ? 363  GLU   A OE2 1 
ATOM   2764 N N   . PHE   A 1 382 ? -12.03206 -1.27320  -16.93673 1.000 11.81546 ? 364  PHE   A N   1 
ATOM   2765 C CA  . PHE   A 1 382 ? -12.51373 0.02240   -16.44990 1.000 7.33980  ? 364  PHE   A CA  1 
ATOM   2766 C C   . PHE   A 1 382 ? -11.35081 0.98747   -16.24979 1.000 10.29935 ? 364  PHE   A C   1 
ATOM   2767 O O   . PHE   A 1 382 ? -11.47174 2.19411   -16.51117 1.000 9.02584  ? 364  PHE   A O   1 
ATOM   2768 C CB  . PHE   A 1 382 ? -13.28662 -0.15947  -15.14090 1.000 10.59063 ? 364  PHE   A CB  1 
ATOM   2769 C CG  . PHE   A 1 382 ? -14.75514 -0.53582  -15.31658 1.000 10.70945 ? 364  PHE   A CG  1 
ATOM   2770 C CD1 . PHE   A 1 382 ? -15.67114 0.37217   -15.85231 1.000 8.46522  ? 364  PHE   A CD1 1 
ATOM   2771 C CD2 . PHE   A 1 382 ? -15.21755 -1.77860  -14.90666 1.000 10.38172 ? 364  PHE   A CD2 1 
ATOM   2772 C CE1 . PHE   A 1 382 ? -17.01768 0.04083   -15.98994 1.000 9.32088  ? 364  PHE   A CE1 1 
ATOM   2773 C CE2 . PHE   A 1 382 ? -16.55761 -2.12843  -15.05150 1.000 10.29325 ? 364  PHE   A CE2 1 
ATOM   2774 C CZ  . PHE   A 1 382 ? -17.46331 -1.20589  -15.59264 1.000 10.67184 ? 364  PHE   A CZ  1 
ATOM   2775 N N   . PHE   A 1 383 ? -10.21289 0.46996   -15.78670 1.000 11.03675 ? 365  PHE   A N   1 
ATOM   2776 C CA  . PHE   A 1 383 ? -9.02879  1.30462   -15.65124 1.000 10.00058 ? 365  PHE   A CA  1 
ATOM   2777 C C   . PHE   A 1 383 ? -8.63874  1.92097   -16.99403 1.000 12.72214 ? 365  PHE   A C   1 
ATOM   2778 O O   . PHE   A 1 383 ? -8.38498  3.12866   -17.08346 1.000 10.80045 ? 365  PHE   A O   1 
ATOM   2779 C CB  . PHE   A 1 383 ? -7.87516  0.48793   -15.06072 1.000 13.83223 ? 365  PHE   A CB  1 
ATOM   2780 C CG  . PHE   A 1 383 ? -6.62857  1.28727   -14.82350 1.000 12.56755 ? 365  PHE   A CG  1 
ATOM   2781 C CD1 . PHE   A 1 383 ? -5.78105  1.60967   -15.87587 1.000 14.71786 ? 365  PHE   A CD1 1 
ATOM   2782 C CD2 . PHE   A 1 383 ? -6.29707  1.71497   -13.54868 1.000 15.87815 ? 365  PHE   A CD2 1 
ATOM   2783 C CE1 . PHE   A 1 383 ? -4.62634  2.35209   -15.66145 1.000 16.65174 ? 365  PHE   A CE1 1 
ATOM   2784 C CE2 . PHE   A 1 383 ? -5.14226  2.45264   -13.32436 1.000 17.72875 ? 365  PHE   A CE2 1 
ATOM   2785 C CZ  . PHE   A 1 383 ? -4.30672  2.77290   -14.38590 1.000 16.55762 ? 365  PHE   A CZ  1 
ATOM   2786 N N   . GLU   A 1 384 ? -8.58360  1.10930   -18.05435 1.000 9.85174  ? 366  GLU   A N   1 
ATOM   2787 C CA  . GLU   A 1 384 ? -8.16599  1.65475   -19.34594 1.000 12.27655 ? 366  GLU   A CA  1 
ATOM   2788 C C   . GLU   A 1 384 ? -9.19107  2.62828   -19.90082 1.000 11.98553 ? 366  GLU   A C   1 
ATOM   2789 O O   . GLU   A 1 384 ? -8.82814  3.60154   -20.56990 1.000 13.16650 ? 366  GLU   A O   1 
ATOM   2790 C CB  . GLU   A 1 384 ? -7.90641  0.53864   -20.35208 1.000 17.09133 ? 366  GLU   A CB  1 
ATOM   2791 C CG  . GLU   A 1 384 ? -6.92102  -0.50251  -19.86675 1.000 21.31647 ? 366  GLU   A CG  1 
ATOM   2792 C CD  . GLU   A 1 384 ? -6.46103  -1.41309  -20.99078 1.000 41.37112 ? 366  GLU   A CD  1 
ATOM   2793 O OE1 . GLU   A 1 384 ? -7.09519  -1.38286  -22.07037 1.000 33.04176 ? 366  GLU   A OE1 1 
ATOM   2794 O OE2 . GLU   A 1 384 ? -5.46765  -2.14758  -20.79547 1.000 45.25401 ? 366  GLU   A OE2 1 
ATOM   2795 N N   . VAL   A 1 385 ? -10.47756 2.36754   -19.66299 1.000 11.93085 ? 367  VAL   A N   1 
ATOM   2796 C CA  . VAL   A 1 385 ? -11.50406 3.31716   -20.08640 1.000 12.31891 ? 367  VAL   A CA  1 
ATOM   2797 C C   . VAL   A 1 385 ? -11.32370 4.64784   -19.37531 1.000 12.64652 ? 367  VAL   A C   1 
ATOM   2798 O O   . VAL   A 1 385 ? -11.27162 5.70875   -20.01060 1.000 11.39455 ? 367  VAL   A O   1 
ATOM   2799 C CB  . VAL   A 1 385 ? -12.90536 2.73629   -19.84423 1.000 11.23623 ? 367  VAL   A CB  1 
ATOM   2800 C CG1 . VAL   A 1 385 ? -13.95878 3.81733   -20.05401 1.000 11.05970 ? 367  VAL   A CG1 1 
ATOM   2801 C CG2 . VAL   A 1 385 ? -13.13295 1.56751   -20.79993 1.000 11.43007 ? 367  VAL   A CG2 1 
ATOM   2802 N N   . ALA   A 1 386 ? -11.25256 4.61529   -18.04085 1.000 8.17460  ? 368  ALA   A N   1 
ATOM   2803 C CA  . ALA   A 1 386 ? -11.17996 5.85466   -17.27283 1.000 9.75035  ? 368  ALA   A CA  1 
ATOM   2804 C C   . ALA   A 1 386 ? -9.89394  6.61634   -17.55101 1.000 10.17300 ? 368  ALA   A C   1 
ATOM   2805 O O   . ALA   A 1 386 ? -9.89753  7.85316   -17.62462 1.000 11.58200 ? 368  ALA   A O   1 
ATOM   2806 C CB  . ALA   A 1 386 ? -11.28824 5.55977   -15.77711 1.000 8.99513  ? 368  ALA   A CB  1 
ATOM   2807 N N   . ASN   A 1 387 ? -8.77812  5.89895   -17.68602 1.000 13.75979 ? 369  ASN   A N   1 
ATOM   2808 C CA  . ASN   A 1 387 ? -7.45919  6.50797   -17.60626 1.000 13.98002 ? 369  ASN   A CA  1 
ATOM   2809 C C   . ASN   A 1 387 ? -6.73375  6.53930   -18.93816 1.000 15.68308 ? 369  ASN   A C   1 
ATOM   2810 O O   . ASN   A 1 387 ? -5.57288  6.96907   -18.99469 1.000 15.00102 ? 369  ASN   A O   1 
ATOM   2811 C CB  . ASN   A 1 387 ? -6.62530  5.78164   -16.54008 1.000 11.06768 ? 369  ASN   A CB  1 
ATOM   2812 C CG  . ASN   A 1 387 ? -7.30310  5.81658   -15.17970 1.000 15.14260 ? 369  ASN   A CG  1 
ATOM   2813 O OD1 . ASN   A 1 387 ? -7.93335  6.81342   -14.83555 1.000 12.24283 ? 369  ASN   A OD1 1 
ATOM   2814 N ND2 . ASN   A 1 387 ? -7.17105  4.74365   -14.39912 1.000 15.36836 ? 369  ASN   A ND2 1 
ATOM   2815 N N   . ASP   A 1 388 ? -7.39363  6.12839   -20.01138 1.000 11.68036 ? 370  ASP   A N   1 
ATOM   2816 C CA  . ASP   A 1 388 ? -6.77408  6.17206   -21.32566 1.000 12.48350 ? 370  ASP   A CA  1 
ATOM   2817 C C   . ASP   A 1 388 ? -7.80797  6.46756   -22.40084 1.000 12.68235 ? 370  ASP   A C   1 
ATOM   2818 O O   . ASP   A 1 388 ? -7.68161  7.45722   -23.12210 1.000 12.46334 ? 370  ASP   A O   1 
ATOM   2819 C CB  . ASP   A 1 388 ? -6.05314  4.85728   -21.62091 1.000 14.45397 ? 370  ASP   A CB  1 
ATOM   2820 C CG  . ASP   A 1 388 ? -5.17532  4.95284   -22.84334 1.000 26.74224 ? 370  ASP   A CG  1 
ATOM   2821 O OD1 . ASP   A 1 388 ? -4.27337  5.81693   -22.85231 1.000 35.42865 ? 370  ASP   A OD1 1 
ATOM   2822 O OD2 . ASP   A 1 388 ? -5.40413  4.18844   -23.79891 1.000 28.66814 ? 370  ASP   A OD2 1 
ATOM   2823 N N   . VAL   A 1 389 ? -8.85141  5.63910   -22.49777 1.000 12.95524 ? 371  VAL   A N   1 
ATOM   2824 C CA  . VAL   A 1 389 ? -9.75287  5.73638   -23.64106 1.000 13.12159 ? 371  VAL   A CA  1 
ATOM   2825 C C   . VAL   A 1 389 ? -10.60308 7.00037   -23.56290 1.000 16.25432 ? 371  VAL   A C   1 
ATOM   2826 O O   . VAL   A 1 389 ? -10.73928 7.72831   -24.55123 1.000 13.27730 ? 371  VAL   A O   1 
ATOM   2827 C CB  . VAL   A 1 389 ? -10.61893 4.47112   -23.76550 1.000 16.13267 ? 371  VAL   A CB  1 
ATOM   2828 C CG1 . VAL   A 1 389 ? -11.51706 4.58114   -24.99608 1.000 16.85739 ? 371  VAL   A CG1 1 
ATOM   2829 C CG2 . VAL   A 1 389 ? -9.72850  3.23065   -23.88344 1.000 13.93037 ? 371  VAL   A CG2 1 
ATOM   2830 N N   . ILE   A 1 390 ? -11.21138 7.27864   -22.40707 1.000 15.94402 ? 372  ILE   A N   1 
ATOM   2831 C CA  . ILE   A 1 390 ? -11.97978 8.52039   -22.27291 1.000 13.80031 ? 372  ILE   A CA  1 
ATOM   2832 C C   . ILE   A 1 390 ? -11.08415 9.75138   -22.38947 1.000 13.62454 ? 372  ILE   A C   1 
ATOM   2833 O O   . ILE   A 1 390 ? -11.45509 10.68836  -23.11508 1.000 11.59140 ? 372  ILE   A O   1 
ATOM   2834 C CB  . ILE   A 1 390 ? -12.81793 8.49956   -20.98547 1.000 13.64703 ? 372  ILE   A CB  1 
ATOM   2835 C CG1 . ILE   A 1 390 ? -14.02706 7.58153   -21.16679 1.000 9.80216  ? 372  ILE   A CG1 1 
ATOM   2836 C CG2 . ILE   A 1 390 ? -13.30021 9.91188   -20.64154 1.000 9.29013  ? 372  ILE   A CG2 1 
ATOM   2837 C CD1 . ILE   A 1 390 ? -14.83977 7.40535   -19.88843 1.000 12.47912 ? 372  ILE   A CD1 1 
ATOM   2838 N N   . PRO   A 1 391 ? -9.91437  9.82320   -21.73140 1.000 14.13169 ? 373  PRO   A N   1 
ATOM   2839 C CA  . PRO   A 1 391 ? -9.00802  10.95692  -22.00920 1.000 12.98556 ? 373  PRO   A CA  1 
ATOM   2840 C C   . PRO   A 1 391 ? -8.69159  11.13773  -23.48859 1.000 12.45093 ? 373  PRO   A C   1 
ATOM   2841 O O   . PRO   A 1 391 ? -8.71362  12.26950  -23.98842 1.000 16.08699 ? 373  PRO   A O   1 
ATOM   2842 C CB  . PRO   A 1 391 ? -7.76087  10.59878  -21.19598 1.000 12.37286 ? 373  PRO   A CB  1 
ATOM   2843 C CG  . PRO   A 1 391 ? -8.30029  9.85080   -20.03805 1.000 11.58279 ? 373  PRO   A CG  1 
ATOM   2844 C CD  . PRO   A 1 391 ? -9.40854  9.00505   -20.60965 1.000 13.18853 ? 373  PRO   A CD  1 
ATOM   2845 N N   . ASN   A 1 392 ? -8.41660  10.04905  -24.20831 1.000 13.10202 ? 374  ASN   A N   1 
ATOM   2846 C CA  . ASN   A 1 392 ? -8.15403  10.15214  -25.64331 1.000 17.50639 ? 374  ASN   A CA  1 
ATOM   2847 C C   . ASN   A 1 392 ? -9.38465  10.63448  -26.40399 1.000 14.90664 ? 374  ASN   A C   1 
ATOM   2848 O O   . ASN   A 1 392 ? -9.27366  11.46338  -27.31399 1.000 15.18103 ? 374  ASN   A O   1 
ATOM   2849 C CB  . ASN   A 1 392 ? -7.69750  8.79883   -26.19163 1.000 13.46399 ? 374  ASN   A CB  1 
ATOM   2850 C CG  . ASN   A 1 392 ? -6.28962  8.45899   -25.78953 1.000 17.00019 ? 374  ASN   A CG  1 
ATOM   2851 O OD1 . ASN   A 1 392 ? -5.57173  9.29972   -25.25554 1.000 20.20825 ? 374  ASN   A OD1 1 
ATOM   2852 N ND2 . ASN   A 1 392 ? -5.88894  7.21987   -26.03095 1.000 22.13804 ? 374  ASN   A ND2 1 
ATOM   2853 N N   . LEU   A 1 393 ? -10.56206 10.10648  -26.06245 1.000 15.45511 ? 375  LEU   A N   1 
ATOM   2854 C CA  . LEU   A 1 393 ? -11.79267 10.55042  -26.71254 1.000 15.76259 ? 375  LEU   A CA  1 
ATOM   2855 C C   . LEU   A 1 393 ? -12.00481 12.04732  -26.52573 1.000 19.17317 ? 375  LEU   A C   1 
ATOM   2856 O O   . LEU   A 1 393 ? -12.36666 12.75836  -27.47340 1.000 17.04073 ? 375  LEU   A O   1 
ATOM   2857 C CB  . LEU   A 1 393 ? -12.98438 9.76681   -26.15982 1.000 16.77171 ? 375  LEU   A CB  1 
ATOM   2858 C CG  . LEU   A 1 393 ? -14.36994 10.01664  -26.76343 1.000 22.77096 ? 375  LEU   A CG  1 
ATOM   2859 C CD1 . LEU   A 1 393 ? -14.45277 9.47219   -28.17788 1.000 24.35908 ? 375  LEU   A CD1 1 
ATOM   2860 C CD2 . LEU   A 1 393 ? -15.45794 9.41042   -25.88550 1.000 20.63273 ? 375  LEU   A CD2 1 
ATOM   2861 N N   . LEU   A 1 394 ? -11.78551 12.54597  -25.30781 1.000 12.46161 ? 376  LEU   A N   1 
ATOM   2862 C CA  . LEU   A 1 394 ? -12.04243 13.95692  -25.04523 1.000 11.51595 ? 376  LEU   A CA  1 
ATOM   2863 C C   . LEU   A 1 394 ? -10.97940 14.83891  -25.68768 1.000 13.14821 ? 376  LEU   A C   1 
ATOM   2864 O O   . LEU   A 1 394 ? -11.29725 15.92872  -26.17949 1.000 12.11161 ? 376  LEU   A O   1 
ATOM   2865 C CB  . LEU   A 1 394 ? -12.12568 14.19938  -23.54061 1.000 11.36087 ? 376  LEU   A CB  1 
ATOM   2866 C CG  . LEU   A 1 394 ? -13.21221 13.40234  -22.80074 1.000 12.48252 ? 376  LEU   A CG  1 
ATOM   2867 C CD1 . LEU   A 1 394 ? -13.13439 13.68791  -21.31481 1.000 10.36324 ? 376  LEU   A CD1 1 
ATOM   2868 C CD2 . LEU   A 1 394 ? -14.63911 13.70409  -23.35255 1.000 14.86814 ? 376  LEU   A CD2 1 
ATOM   2869 N N   . LYS   A 1 395 ? -9.72915  14.36851  -25.72425 1.000 16.16190 ? 377  LYS   A N   1 
ATOM   2870 C CA  . LYS   A 1 395 ? -8.67212  15.09802  -26.42597 1.000 15.82730 ? 377  LYS   A CA  1 
ATOM   2871 C C   . LYS   A 1 395 ? -8.97666  15.20855  -27.91718 1.000 14.47856 ? 377  LYS   A C   1 
ATOM   2872 O O   . LYS   A 1 395 ? -8.80448  16.27589  -28.51489 1.000 16.68091 ? 377  LYS   A O   1 
ATOM   2873 C CB  . LYS   A 1 395 ? -7.32402  14.40953  -26.19586 1.000 19.11004 ? 377  LYS   A CB  1 
ATOM   2874 C CG  . LYS   A 1 395 ? -6.21161  14.87956  -27.13907 1.000 28.20431 ? 377  LYS   A CG  1 
ATOM   2875 C CD  . LYS   A 1 395 ? -4.96161  14.00968  -27.02774 1.000 29.10199 ? 377  LYS   A CD  1 
ATOM   2876 C CE  . LYS   A 1 395 ? -3.86993  14.68159  -26.20689 1.000 45.51019 ? 377  LYS   A CE  1 
ATOM   2877 N NZ  . LYS   A 1 395 ? -2.63774  13.83536  -26.14494 1.000 50.46080 ? 377  LYS   A NZ  1 
ATOM   2878 N N   . GLU   A 1 396 ? -9.43700  14.11289  -28.52915 1.000 18.54911 ? 378  GLU   A N   1 
ATOM   2879 C CA  . GLU   A 1 396 ? -9.93756  14.14973  -29.90093 1.000 25.35496 ? 378  GLU   A CA  1 
ATOM   2880 C C   . GLU   A 1 396 ? -11.02604 15.19964  -30.08400 1.000 20.16671 ? 378  GLU   A C   1 
ATOM   2881 O O   . GLU   A 1 396 ? -10.98843 15.99755  -31.02769 1.000 23.06092 ? 378  GLU   A O   1 
ATOM   2882 C CB  . GLU   A 1 396 ? -10.47916 12.77387  -30.29267 1.000 21.62765 ? 378  GLU   A CB  1 
ATOM   2883 C CG  . GLU   A 1 396 ? -10.86428 12.70394  -31.74722 1.000 34.05047 ? 378  GLU   A CG  1 
ATOM   2884 C CD  . GLU   A 1 396 ? -9.79430  12.08845  -32.61025 1.000 44.07878 ? 378  GLU   A CD  1 
ATOM   2885 O OE1 . GLU   A 1 396 ? -9.58789  10.86227  -32.50230 1.000 58.00659 ? 378  GLU   A OE1 1 
ATOM   2886 O OE2 . GLU   A 1 396 ? -9.14249  12.83438  -33.37216 1.000 40.81899 ? 378  GLU   A OE2 1 
ATOM   2887 N N   . ALA   A 1 397 ? -12.02778 15.18971  -29.20548 1.000 17.23967 ? 379  ALA   A N   1 
ATOM   2888 C CA  . ALA   A 1 397 ? -13.10984 16.16055  -29.31395 1.000 13.68784 ? 379  ALA   A CA  1 
ATOM   2889 C C   . ALA   A 1 397 ? -12.59187 17.58271  -29.14818 1.000 23.06809 ? 379  ALA   A C   1 
ATOM   2890 O O   . ALA   A 1 397 ? -13.04567 18.50145  -29.84078 1.000 18.99652 ? 379  ALA   A O   1 
ATOM   2891 C CB  . ALA   A 1 397 ? -14.18977 15.85485  -28.27561 1.000 17.04020 ? 379  ALA   A CB  1 
ATOM   2892 N N   . ALA   A 1 398 ? -11.63342 17.78477  -28.24083 1.000 14.53911 ? 380  ALA   A N   1 
ATOM   2893 C CA  . ALA   A 1 398 ? -11.07023 19.11992  -28.05397 1.000 13.77551 ? 380  ALA   A CA  1 
ATOM   2894 C C   . ALA   A 1 398 ? -10.35512 19.61285  -29.30816 1.000 17.72362 ? 380  ALA   A C   1 
ATOM   2895 O O   . ALA   A 1 398 ? -10.39004 20.81052  -29.61256 1.000 17.67724 ? 380  ALA   A O   1 
ATOM   2896 C CB  . ALA   A 1 398 ? -10.11076 19.12557  -26.86443 1.000 15.35490 ? 380  ALA   A CB  1 
ATOM   2897 N N   . SER   A 1 399 ? -9.71800  18.70733  -30.05190 1.000 14.63280 ? 381  SER   A N   1 
ATOM   2898 C CA  . SER   A 1 399 ? -9.03507  19.09979  -31.28199 1.000 21.68294 ? 381  SER   A CA  1 
ATOM   2899 C C   . SER   A 1 399 ? -10.02089 19.56390  -32.35366 1.000 26.09238 ? 381  SER   A C   1 
ATOM   2900 O O   . SER   A 1 399 ? -9.68139  20.42042  -33.17741 1.000 21.35489 ? 381  SER   A O   1 
ATOM   2901 C CB  . SER   A 1 399 ? -8.16150  17.94022  -31.77792 1.000 23.35776 ? 381  SER   A CB  1 
ATOM   2902 O OG  . SER   A 1 399 ? -8.88298  17.04723  -32.61368 1.000 25.07437 ? 381  SER   A OG  1 
ATOM   2903 N N   . LEU   A 1 400 ? -11.24471 19.03607  -32.34885 1.000 24.56256 ? 382  LEU   A N   1 
ATOM   2904 C CA  . LEU   A 1 400 ? -12.28686 19.55733  -33.23476 1.000 21.89703 ? 382  LEU   A CA  1 
ATOM   2905 C C   . LEU   A 1 400 ? -12.76432 20.93191  -32.79417 1.000 28.36411 ? 382  LEU   A C   1 
ATOM   2906 O O   . LEU   A 1 400 ? -12.91997 21.83773  -33.62234 1.000 28.76735 ? 382  LEU   A O   1 
ATOM   2907 C CB  . LEU   A 1 400 ? -13.47086 18.59006  -33.28440 1.000 35.49383 ? 382  LEU   A CB  1 
ATOM   2908 C CG  . LEU   A 1 400 ? -13.20525 17.21643  -33.87229 1.000 35.02781 ? 382  LEU   A CG  1 
ATOM   2909 C CD1 . LEU   A 1 400 ? -14.51473 16.62694  -34.35629 1.000 33.98173 ? 382  LEU   A CD1 1 
ATOM   2910 C CD2 . LEU   A 1 400 ? -12.23601 17.37336  -35.03748 1.000 41.05300 ? 382  LEU   A CD2 1 
ATOM   2911 N N   . LEU   A 1 401 ? -13.03042 21.09398  -31.49401 1.000 26.45087 ? 383  LEU   A N   1 
ATOM   2912 C CA  . LEU   A 1 401 ? -13.52967 22.36472  -30.97491 1.000 29.42354 ? 383  LEU   A CA  1 
ATOM   2913 C C   . LEU   A 1 401 ? -12.54308 23.49777  -31.20990 1.000 38.64041 ? 383  LEU   A C   1 
ATOM   2914 O O   . LEU   A 1 401 ? -12.94416 24.61507  -31.56072 1.000 29.45619 ? 383  LEU   A O   1 
ATOM   2915 C CB  . LEU   A 1 401 ? -13.83613 22.23728  -29.48413 1.000 30.49432 ? 383  LEU   A CB  1 
ATOM   2916 C CG  . LEU   A 1 401 ? -14.72288 23.33578  -28.89558 1.000 30.70062 ? 383  LEU   A CG  1 
ATOM   2917 C CD1 . LEU   A 1 401 ? -15.94043 23.59652  -29.76602 1.000 32.60350 ? 383  LEU   A CD1 1 
ATOM   2918 C CD2 . LEU   A 1 401 ? -15.12508 22.99214  -27.46965 1.000 26.29633 ? 383  LEU   A CD2 1 
ATOM   2919 N N   . GLU   A 1 402 ? -11.24897 23.22752  -31.01239 1.000 34.68029 ? 384  GLU   A N   1 
ATOM   2920 C CA  . GLU   A 1 402 ? -10.22375 24.25114  -31.18977 1.000 39.00422 ? 384  GLU   A CA  1 
ATOM   2921 C C   . GLU   A 1 402 ? -10.18997 24.77736  -32.62079 1.000 36.96803 ? 384  GLU   A C   1 
ATOM   2922 O O   . GLU   A 1 402 ? -9.81907  25.93522  -32.84675 1.000 36.93328 ? 384  GLU   A O   1 
ATOM   2923 C CB  . GLU   A 1 402 ? -8.85880  23.67617  -30.80089 1.000 40.66840 ? 384  GLU   A CB  1 
ATOM   2924 C CG  . GLU   A 1 402 ? -8.27054  22.74647  -31.86339 1.000 42.75837 ? 384  GLU   A CG  1 
ATOM   2925 C CD  . GLU   A 1 402 ? -6.97786  22.07846  -31.44031 1.000 30.40007 ? 384  GLU   A CD  1 
ATOM   2926 O OE1 . GLU   A 1 402 ? -6.58427  22.22189  -30.26426 1.000 38.96310 ? 384  GLU   A OE1 1 
ATOM   2927 O OE2 . GLU   A 1 402 ? -6.36293  21.39793  -32.29023 1.000 49.51211 ? 384  GLU   A OE2 1 
ATOM   2928 N N   . ALA   A 1 403 ? -10.59176 23.95723  -33.59025 1.000 35.26870 ? 385  ALA   A N   1 
ATOM   2929 C CA  . ALA   A 1 403 ? -10.44937 24.29089  -35.00659 1.000 41.77270 ? 385  ALA   A CA  1 
ATOM   2930 C C   . ALA   A 1 403 ? -11.55668 25.22163  -35.49559 1.000 42.20620 ? 385  ALA   A C   1 
ATOM   2931 O O   . ALA   A 1 403 ? -11.34471 26.02524  -36.41085 1.000 51.00369 ? 385  ALA   A O   1 
ATOM   2932 C CB  . ALA   A 1 403 ? -10.41527 23.00691  -35.85151 1.000 29.16311 ? 385  ALA   A CB  1 
ATOM   2933 N N   . GLY   A 1 419 ? -23.26417 20.62819  -32.36359 1.000 41.61690 ? 401  GLY   A N   1 
ATOM   2934 C CA  . GLY   A 1 419 ? -22.12666 21.25860  -31.71692 1.000 29.30632 ? 401  GLY   A CA  1 
ATOM   2935 C C   . GLY   A 1 419 ? -21.17955 20.26733  -31.06214 1.000 40.77280 ? 401  GLY   A C   1 
ATOM   2936 O O   . GLY   A 1 419 ? -21.45986 19.06032  -31.01858 1.000 40.54464 ? 401  GLY   A O   1 
ATOM   2937 N N   . SER   A 1 420 ? -20.05843 20.77729  -30.55004 1.000 30.29183 ? 402  SER   A N   1 
ATOM   2938 C CA  . SER   A 1 420 ? -19.04700 19.91538  -29.94949 1.000 27.13650 ? 402  SER   A CA  1 
ATOM   2939 C C   . SER   A 1 420 ? -19.59183 19.21861  -28.70766 1.000 28.06885 ? 402  SER   A C   1 
ATOM   2940 O O   . SER   A 1 420 ? -20.35193 19.80270  -27.92528 1.000 20.59947 ? 402  SER   A O   1 
ATOM   2941 C CB  . SER   A 1 420 ? -17.81031 20.72586  -29.58221 1.000 26.91678 ? 402  SER   A CB  1 
ATOM   2942 O OG  . SER   A 1 420 ? -16.96473 20.00666  -28.69230 1.000 30.52911 ? 402  SER   A OG  1 
ATOM   2943 N N   . ALA   A 1 421 ? -19.19085 17.95486  -28.53196 1.000 21.50287 ? 403  ALA   A N   1 
ATOM   2944 C CA  . ALA   A 1 421 ? -19.60133 17.19561  -27.35394 1.000 21.84498 ? 403  ALA   A CA  1 
ATOM   2945 C C   . ALA   A 1 421 ? -19.07668 17.81013  -26.06517 1.000 18.95001 ? 403  ALA   A C   1 
ATOM   2946 O O   . ALA   A 1 421 ? -19.69846 17.64317  -25.00886 1.000 14.16263 ? 403  ALA   A O   1 
ATOM   2947 C CB  . ALA   A 1 421 ? -19.13204 15.74685  -27.46680 1.000 26.09816 ? 403  ALA   A CB  1 
ATOM   2948 N N   . LEU   A 1 422 ? -17.94006 18.52256  -26.12005 1.000 15.69201 ? 404  LEU   A N   1 
ATOM   2949 C CA  . LEU   A 1 422 ? -17.42310 19.15639  -24.91397 1.000 12.95141 ? 404  LEU   A CA  1 
ATOM   2950 C C   . LEU   A 1 422 ? -18.25224 20.35488  -24.48240 1.000 17.05914 ? 404  LEU   A C   1 
ATOM   2951 O O   . LEU   A 1 422 ? -18.04326 20.87110  -23.38080 1.000 17.04016 ? 404  LEU   A O   1 
ATOM   2952 C CB  . LEU   A 1 422 ? -15.96770 19.58664  -25.10474 1.000 16.09675 ? 404  LEU   A CB  1 
ATOM   2953 C CG  . LEU   A 1 422 ? -14.99104 18.47391  -25.46652 1.000 16.20474 ? 404  LEU   A CG  1 
ATOM   2954 C CD1 . LEU   A 1 422 ? -13.57318 19.03793  -25.53085 1.000 15.91966 ? 404  LEU   A CD1 1 
ATOM   2955 C CD2 . LEU   A 1 422 ? -15.07103 17.32920  -24.46450 1.000 14.38531 ? 404  LEU   A CD2 1 
ATOM   2956 N N   . GLN   A 1 423 ? -19.17805 20.80863  -25.31754 1.000 16.56198 ? 405  GLN   A N   1 
ATOM   2957 C CA  . GLN   A 1 423 ? -20.07494 21.90119  -24.97171 1.000 17.51401 ? 405  GLN   A CA  1 
ATOM   2958 C C   . GLN   A 1 423 ? -21.45923 21.39961  -24.58520 1.000 17.86433 ? 405  GLN   A C   1 
ATOM   2959 O O   . GLN   A 1 423 ? -22.37230 22.20500  -24.39314 1.000 18.09206 ? 405  GLN   A O   1 
ATOM   2960 C CB  . GLN   A 1 423 ? -20.15815 22.87520  -26.14582 1.000 18.31285 ? 405  GLN   A CB  1 
ATOM   2961 C CG  . GLN   A 1 423 ? -18.87020 23.62808  -26.36473 1.000 25.20340 ? 405  GLN   A CG  1 
ATOM   2962 C CD  . GLN   A 1 423 ? -18.88982 24.48447  -27.61694 1.000 42.27051 ? 405  GLN   A CD  1 
ATOM   2963 O OE1 . GLN   A 1 423 ? -19.46924 24.10660  -28.64257 1.000 35.95259 ? 405  GLN   A OE1 1 
ATOM   2964 N NE2 . GLN   A 1 423 ? -18.26395 25.65443  -27.53607 1.000 33.40590 ? 405  GLN   A NE2 1 
ATOM   2965 N N   . ASP   A 1 424 ? -21.62538 20.08704  -24.46127 1.000 15.36228 ? 406  ASP   A N   1 
ATOM   2966 C CA  . ASP   A 1 424 ? -22.92163 19.46659  -24.22030 1.000 19.50980 ? 406  ASP   A CA  1 
ATOM   2967 C C   . ASP   A 1 424 ? -22.98325 18.97383  -22.78087 1.000 18.30750 ? 406  ASP   A C   1 
ATOM   2968 O O   . ASP   A 1 424 ? -22.29308 18.00170  -22.43929 1.000 14.70777 ? 406  ASP   A O   1 
ATOM   2969 C CB  . ASP   A 1 424 ? -23.13185 18.30682  -25.19839 1.000 16.62174 ? 406  ASP   A CB  1 
ATOM   2970 C CG  . ASP   A 1 424 ? -24.51146 17.66173  -25.07346 1.000 19.92803 ? 406  ASP   A CG  1 
ATOM   2971 O OD1 . ASP   A 1 424 ? -25.29534 18.04899  -24.17887 1.000 19.65624 ? 406  ASP   A OD1 1 
ATOM   2972 O OD2 . ASP   A 1 424 ? -24.80582 16.74887  -25.87081 1.000 22.48652 ? 406  ASP   A OD2 1 
ATOM   2973 N N   . PRO   A 1 425 ? -23.77787 19.59369  -21.90677 1.000 14.73971 ? 407  PRO   A N   1 
ATOM   2974 C CA  . PRO   A 1 425 ? -23.85577 19.10368  -20.51852 1.000 9.14631  ? 407  PRO   A CA  1 
ATOM   2975 C C   . PRO   A 1 425 ? -24.29259 17.64820  -20.39155 1.000 9.21015  ? 407  PRO   A C   1 
ATOM   2976 O O   . PRO   A 1 425 ? -23.97014 17.00601  -19.38318 1.000 12.85910 ? 407  PRO   A O   1 
ATOM   2977 C CB  . PRO   A 1 425 ? -24.86935 20.06247  -19.87466 1.000 13.87834 ? 407  PRO   A CB  1 
ATOM   2978 C CG  . PRO   A 1 425 ? -24.72747 21.31651  -20.66214 1.000 17.63158 ? 407  PRO   A CG  1 
ATOM   2979 C CD  . PRO   A 1 425 ? -24.51580 20.85670  -22.08662 1.000 14.22473 ? 407  PRO   A CD  1 
ATOM   2980 N N   . GLU   A 1 426 ? -25.02086 17.10310  -21.37274 1.000 10.68934 ? 408  GLU   A N   1 
ATOM   2981 C CA  . GLU   A 1 426 ? -25.35679 15.68034  -21.32947 1.000 9.72421  ? 408  GLU   A CA  1 
ATOM   2982 C C   . GLU   A 1 426 ? -24.10512 14.81669  -21.35848 1.000 13.68856 ? 408  GLU   A C   1 
ATOM   2983 O O   . GLU   A 1 426 ? -24.03372 13.78957  -20.67438 1.000 12.97311 ? 408  GLU   A O   1 
ATOM   2984 C CB  . GLU   A 1 426 ? -26.27540 15.31791  -22.49745 1.000 10.26983 ? 408  GLU   A CB  1 
ATOM   2985 C CG  . GLU   A 1 426 ? -26.86390 13.92700  -22.41679 1.000 21.14994 ? 408  GLU   A CG  1 
ATOM   2986 C CD  . GLU   A 1 426 ? -27.39791 13.44616  -23.75824 1.000 33.35203 ? 408  GLU   A CD  1 
ATOM   2987 O OE1 . GLU   A 1 426 ? -28.08357 14.24737  -24.43757 1.000 28.15441 ? 408  GLU   A OE1 1 
ATOM   2988 O OE2 . GLU   A 1 426 ? -27.14516 12.27325  -24.12106 1.000 24.84291 ? 408  GLU   A OE2 1 
ATOM   2989 N N   . CYS   A 1 427 ? -23.11408 15.20704  -22.15923 1.000 16.16162 ? 409  CYS   A N   1 
ATOM   2990 C CA  . CYS   A 1 427 ? -21.86281 14.46082  -22.19306 1.000 14.30222 ? 409  CYS   A CA  1 
ATOM   2991 C C   . CYS   A 1 427 ? -21.14754 14.52622  -20.85671 1.000 12.47488 ? 409  CYS   A C   1 
ATOM   2992 O O   . CYS   A 1 427 ? -20.59267 13.52135  -20.38993 1.000 11.53107 ? 409  CYS   A O   1 
ATOM   2993 C CB  . CYS   A 1 427 ? -20.95908 15.00276  -23.29449 1.000 14.78727 ? 409  CYS   A CB  1 
ATOM   2994 S SG  . CYS   A 1 427 ? -21.56675 14.59361  -24.93051 1.000 20.15995 ? 409  CYS   A SG  1 
ATOM   2995 N N   . PHE   A 1 428 ? -21.11292 15.71388  -20.25155 1.000 10.00131 ? 410  PHE   A N   1 
ATOM   2996 C CA  . PHE   A 1 428 ? -20.52021 15.85602  -18.93218 1.000 9.51100  ? 410  PHE   A CA  1 
ATOM   2997 C C   . PHE   A 1 428 ? -21.24217 14.98711  -17.90693 1.000 10.83414 ? 410  PHE   A C   1 
ATOM   2998 O O   . PHE   A 1 428 ? -20.60132 14.33763  -17.06881 1.000 8.01647  ? 410  PHE   A O   1 
ATOM   2999 C CB  . PHE   A 1 428 ? -20.55126 17.32902  -18.51377 1.000 6.13674  ? 410  PHE   A CB  1 
ATOM   3000 C CG  . PHE   A 1 428 ? -19.91523 17.58659  -17.17661 1.000 10.60785 ? 410  PHE   A CG  1 
ATOM   3001 C CD1 . PHE   A 1 428 ? -18.57162 17.26661  -16.95599 1.000 11.83600 ? 410  PHE   A CD1 1 
ATOM   3002 C CD2 . PHE   A 1 428 ? -20.65173 18.13550  -16.13649 1.000 11.15879 ? 410  PHE   A CD2 1 
ATOM   3003 C CE1 . PHE   A 1 428 ? -17.98069 17.50072  -15.72345 1.000 10.30840 ? 410  PHE   A CE1 1 
ATOM   3004 C CE2 . PHE   A 1 428 ? -20.06598 18.37315  -14.89732 1.000 11.69827 ? 410  PHE   A CE2 1 
ATOM   3005 C CZ  . PHE   A 1 428 ? -18.72880 18.04725  -14.68918 1.000 12.77857 ? 410  PHE   A CZ  1 
ATOM   3006 N N   . ALA   A 1 429 ? -22.58172 14.97964  -17.94283 1.000 7.49375  ? 411  ALA   A N   1 
ATOM   3007 C CA  . ALA   A 1 429 ? -23.33995 14.14516  -17.01965 1.000 8.40196  ? 411  ALA   A CA  1 
ATOM   3008 C C   . ALA   A 1 429 ? -23.04788 12.66647  -17.23803 1.000 11.91496 ? 411  ALA   A C   1 
ATOM   3009 O O   . ALA   A 1 429 ? -23.00051 11.89224  -16.27582 1.000 12.06209 ? 411  ALA   A O   1 
ATOM   3010 C CB  . ALA   A 1 429 ? -24.84259 14.42397  -17.16873 1.000 8.97209  ? 411  ALA   A CB  1 
ATOM   3011 N N   . HIS   A 1 430 ? -22.85808 12.24698  -18.49642 1.000 8.55215  ? 412  HIS   A N   1 
ATOM   3012 C CA  . HIS   A 1 430 ? -22.51322 10.84895  -18.74388 1.000 7.78687  ? 412  HIS   A CA  1 
ATOM   3013 C C   . HIS   A 1 430 ? -21.16570 10.50160  -18.12596 1.000 7.74386  ? 412  HIS   A C   1 
ATOM   3014 O O   . HIS   A 1 430 ? -20.98791 9.40645   -17.57391 1.000 10.12455 ? 412  HIS   A O   1 
ATOM   3015 C CB  . HIS   A 1 430 ? -22.48933 10.55636  -20.24374 1.000 13.85479 ? 412  HIS   A CB  1 
ATOM   3016 C CG  . HIS   A 1 430 ? -23.84300 10.52205  -20.88277 1.000 15.22789 ? 412  HIS   A CG  1 
ATOM   3017 N ND1 . HIS   A 1 430 ? -24.95403 9.98823   -20.26148 1.000 18.85798 ? 412  HIS   A ND1 1 
ATOM   3018 C CD2 . HIS   A 1 430 ? -24.25933 10.94452  -22.09979 1.000 16.79096 ? 412  HIS   A CD2 1 
ATOM   3019 C CE1 . HIS   A 1 430 ? -25.99511 10.08224  -21.07012 1.000 17.83307 ? 412  HIS   A CE1 1 
ATOM   3020 N NE2 . HIS   A 1 430 ? -25.60123 10.66242  -22.19056 1.000 16.85033 ? 412  HIS   A NE2 1 
ATOM   3021 N N   . LEU   A 1 431 ? -20.20298 11.42170  -18.21850 1.000 11.05388 ? 413  LEU   A N   1 
ATOM   3022 C CA  . LEU   A 1 431 ? -18.90691 11.21369  -17.58544 1.000 10.01616 ? 413  LEU   A CA  1 
ATOM   3023 C C   . LEU   A 1 431 ? -19.05293 11.06090  -16.07565 1.000 14.56317 ? 413  LEU   A C   1 
ATOM   3024 O O   . LEU   A 1 431 ? -18.41874 10.19440  -15.46037 1.000 8.35045  ? 413  LEU   A O   1 
ATOM   3025 C CB  . LEU   A 1 431 ? -17.97721 12.37850  -17.91885 1.000 9.29799  ? 413  LEU   A CB  1 
ATOM   3026 C CG  . LEU   A 1 431 ? -16.58566 12.33341  -17.27962 1.000 13.44245 ? 413  LEU   A CG  1 
ATOM   3027 C CD1 . LEU   A 1 431 ? -15.75808 11.23203  -17.90623 1.000 11.69854 ? 413  LEU   A CD1 1 
ATOM   3028 C CD2 . LEU   A 1 431 ? -15.88215 13.67248  -17.42750 1.000 16.19769 ? 413  LEU   A CD2 1 
ATOM   3029 N N   . LEU   A 1 432 ? -19.89122 11.88784  -15.46214 1.000 8.37607  ? 414  LEU   A N   1 
ATOM   3030 C CA  . LEU   A 1 432 ? -20.06797 11.79895  -14.01496 1.000 11.29096 ? 414  LEU   A CA  1 
ATOM   3031 C C   . LEU   A 1 432 ? -20.77908 10.51192  -13.62664 1.000 12.06788 ? 414  LEU   A C   1 
ATOM   3032 O O   . LEU   A 1 432 ? -20.48357 9.91532   -12.58049 1.000 13.00703 ? 414  LEU   A O   1 
ATOM   3033 C CB  . LEU   A 1 432 ? -20.85429 13.00479  -13.52158 1.000 9.49421  ? 414  LEU   A CB  1 
ATOM   3034 C CG  . LEU   A 1 432 ? -20.18059 14.35678  -13.78273 1.000 13.19638 ? 414  LEU   A CG  1 
ATOM   3035 C CD1 . LEU   A 1 432 ? -20.93684 15.46164  -13.07201 1.000 14.75597 ? 414  LEU   A CD1 1 
ATOM   3036 C CD2 . LEU   A 1 432 ? -18.71369 14.33930  -13.37243 1.000 15.96922 ? 414  LEU   A CD2 1 
ATOM   3037 N N   . ARG   A 1 433 ? -21.74474 10.09310  -14.43984 1.000 9.76926  ? 415  ARG   A N   1 
ATOM   3038 C CA  . ARG   A 1 433 ? -22.45819 8.84828   -14.17258 1.000 11.67005 ? 415  ARG   A CA  1 
ATOM   3039 C C   . ARG   A 1 433 ? -21.51928 7.64835   -14.24977 1.000 11.83341 ? 415  ARG   A C   1 
ATOM   3040 O O   . ARG   A 1 433 ? -21.64619 6.70310   -13.46709 1.000 12.04050 ? 415  ARG   A O   1 
ATOM   3041 C CB  . ARG   A 1 433 ? -23.61023 8.69939   -15.15959 1.000 9.00294  ? 415  ARG   A CB  1 
ATOM   3042 C CG  . ARG   A 1 433 ? -24.53861 7.53099   -14.88001 1.000 13.18761 ? 415  ARG   A CG  1 
ATOM   3043 C CD  . ARG   A 1 433 ? -25.81759 7.71060   -15.68008 1.000 40.15185 ? 415  ARG   A CD  1 
ATOM   3044 N NE  . ARG   A 1 433 ? -25.62267 7.19618   -17.03049 1.000 37.24690 ? 415  ARG   A NE  1 
ATOM   3045 C CZ  . ARG   A 1 433 ? -26.53468 7.20113   -17.98994 1.000 40.40320 ? 415  ARG   A CZ  1 
ATOM   3046 N NH1 . ARG   A 1 433 ? -27.73731 7.70952   -17.79614 1.000 45.10098 ? 415  ARG   A NH1 1 
ATOM   3047 N NH2 . ARG   A 1 433 ? -26.22835 6.68368   -19.17662 1.000 38.14524 ? 415  ARG   A NH2 1 
ATOM   3048 N N   . PHE   A 1 434 ? -20.57141 7.67866   -15.18863 1.000 11.66331 ? 416  PHE   A N   1 
ATOM   3049 C CA  . PHE   A 1 434 ? -19.53996 6.64885   -15.28123 1.000 12.81213 ? 416  PHE   A CA  1 
ATOM   3050 C C   . PHE   A 1 434 ? -18.74793 6.55044   -13.98206 1.000 10.10662 ? 416  PHE   A C   1 
ATOM   3051 O O   . PHE   A 1 434 ? -18.57880 5.45946   -13.41924 1.000 12.70594 ? 416  PHE   A O   1 
ATOM   3052 C CB  . PHE   A 1 434 ? -18.62529 6.95807   -16.47539 1.000 9.95845  ? 416  PHE   A CB  1 
ATOM   3053 C CG  . PHE   A 1 434 ? -17.41048 6.06728   -16.57769 1.000 13.76279 ? 416  PHE   A CG  1 
ATOM   3054 C CD1 . PHE   A 1 434 ? -17.51478 4.77390   -17.06505 1.000 11.92591 ? 416  PHE   A CD1 1 
ATOM   3055 C CD2 . PHE   A 1 434 ? -16.16232 6.54025   -16.19708 1.000 12.81200 ? 416  PHE   A CD2 1 
ATOM   3056 C CE1 . PHE   A 1 434 ? -16.39813 3.95446   -17.16873 1.000 15.35217 ? 416  PHE   A CE1 1 
ATOM   3057 C CE2 . PHE   A 1 434 ? -15.03952 5.73227   -16.28545 1.000 16.63112 ? 416  PHE   A CE2 1 
ATOM   3058 C CZ  . PHE   A 1 434 ? -15.15138 4.43956   -16.78023 1.000 14.02507 ? 416  PHE   A CZ  1 
ATOM   3059 N N   . TYR   A 1 435 ? -18.27230 7.68447   -13.47273 1.000 10.53599 ? 417  TYR   A N   1 
ATOM   3060 C CA  . TYR   A 1 435 ? -17.52230 7.64441   -12.22418 1.000 9.79916  ? 417  TYR   A CA  1 
ATOM   3061 C C   . TYR   A 1 435 ? -18.41732 7.27012   -11.04637 1.000 10.79074 ? 417  TYR   A C   1 
ATOM   3062 O O   . TYR   A 1 435 ? -17.97669 6.56648   -10.13058 1.000 10.53205 ? 417  TYR   A O   1 
ATOM   3063 C CB  . TYR   A 1 435 ? -16.83132 8.99031   -11.98701 1.000 8.60084  ? 417  TYR   A CB  1 
ATOM   3064 C CG  . TYR   A 1 435 ? -15.52038 9.10204   -12.75324 1.000 9.37894  ? 417  TYR   A CG  1 
ATOM   3065 C CD1 . TYR   A 1 435 ? -14.33059 8.66279   -12.18633 1.000 9.81430  ? 417  TYR   A CD1 1 
ATOM   3066 C CD2 . TYR   A 1 435 ? -15.48187 9.62707   -14.04272 1.000 10.10747 ? 417  TYR   A CD2 1 
ATOM   3067 C CE1 . TYR   A 1 435 ? -13.13272 8.74769   -12.87465 1.000 9.46636  ? 417  TYR   A CE1 1 
ATOM   3068 C CE2 . TYR   A 1 435 ? -14.26823 9.71685   -14.75525 1.000 11.25386 ? 417  TYR   A CE2 1 
ATOM   3069 C CZ  . TYR   A 1 435 ? -13.09893 9.26502   -14.15698 1.000 12.90020 ? 417  TYR   A CZ  1 
ATOM   3070 O OH  . TYR   A 1 435 ? -11.87412 9.34374   -14.81276 1.000 11.77172 ? 417  TYR   A OH  1 
ATOM   3071 N N   . ASP   A 1 436 ? -19.68168 7.70896   -11.06081 1.000 9.21384  ? 418  ASP   A N   1 
ATOM   3072 C CA  . ASP   A 1 436 ? -20.60136 7.35085   -9.97921  1.000 11.30451 ? 418  ASP   A CA  1 
ATOM   3073 C C   . ASP   A 1 436 ? -20.80908 5.84209   -9.90152  1.000 12.51313 ? 418  ASP   A C   1 
ATOM   3074 O O   . ASP   A 1 436 ? -20.86444 5.27270   -8.80382  1.000 11.07107 ? 418  ASP   A O   1 
ATOM   3075 C CB  . ASP   A 1 436 ? -21.94179 8.06838   -10.16011 1.000 11.28317 ? 418  ASP   A CB  1 
ATOM   3076 C CG  . ASP   A 1 436 ? -22.84101 7.95864   -8.93111  1.000 16.47381 ? 418  ASP   A CG  1 
ATOM   3077 O OD1 . ASP   A 1 436 ? -22.34289 8.15628   -7.80784  1.000 12.94105 ? 418  ASP   A OD1 1 
ATOM   3078 O OD2 . ASP   A 1 436 ? -24.05149 7.66374   -9.08341  1.000 16.95181 ? 418  ASP   A OD2 1 
ATOM   3079 N N   . GLY   A 1 437 ? -20.91593 5.17323   -11.05259 1.000 12.39971 ? 419  GLY   A N   1 
ATOM   3080 C CA  . GLY   A 1 437 ? -21.08164 3.72589   -11.03796 1.000 9.96915  ? 419  GLY   A CA  1 
ATOM   3081 C C   . GLY   A 1 437 ? -19.85947 3.00996   -10.49015 1.000 14.39689 ? 419  GLY   A C   1 
ATOM   3082 O O   . GLY   A 1 437 ? -19.98217 2.03746   -9.74136  1.000 10.91147 ? 419  GLY   A O   1 
ATOM   3083 N N   . ILE   A 1 438 ? -18.66805 3.48395   -10.85902 1.000 11.15415 ? 420  ILE   A N   1 
ATOM   3084 C CA  . ILE   A 1 438 ? -17.41724 2.92834   -10.34030 1.000 12.02589 ? 420  ILE   A CA  1 
ATOM   3085 C C   . ILE   A 1 438 ? -17.33557 3.11452   -8.82869  1.000 12.93816 ? 420  ILE   A C   1 
ATOM   3086 O O   . ILE   A 1 438 ? -16.91172 2.21131   -8.09034  1.000 11.43143 ? 420  ILE   A O   1 
ATOM   3087 C CB  . ILE   A 1 438 ? -16.22058 3.60068   -11.04245 1.000 10.58047 ? 420  ILE   A CB  1 
ATOM   3088 C CG1 . ILE   A 1 438 ? -16.27695 3.40647   -12.55519 1.000 15.80205 ? 420  ILE   A CG1 1 
ATOM   3089 C CG2 . ILE   A 1 438 ? -14.89158 3.07307   -10.49093 1.000 13.95644 ? 420  ILE   A CG2 1 
ATOM   3090 C CD1 . ILE   A 1 438 ? -16.20460 1.99243   -12.95979 1.000 16.86074 ? 420  ILE   A CD1 1 
ATOM   3091 N N   . CYS   A 1 439 ? -17.69478 4.30609   -8.34941  1.000 10.10505 ? 421  CYS   A N   1 
ATOM   3092 C CA  . CYS   A 1 439 ? -17.63338 4.56672   -6.91532  1.000 13.03014 ? 421  CYS   A CA  1 
ATOM   3093 C C   . CYS   A 1 439 ? -18.62622 3.69889   -6.16211  1.000 12.57464 ? 421  CYS   A C   1 
ATOM   3094 O O   . CYS   A 1 439 ? -18.31304 3.17626   -5.08731  1.000 14.08710 ? 421  CYS   A O   1 
ATOM   3095 C CB  . CYS   A 1 439 ? -17.89834 6.04618   -6.62939  1.000 14.11275 ? 421  CYS   A CB  1 
ATOM   3096 S SG  . CYS   A 1 439 ? -16.58773 7.15023   -7.11855  1.000 12.49906 ? 421  CYS   A SG  1 
ATOM   3097 N N   . LYS   A 1 440 ? -19.82928 3.52831   -6.71287  1.000 13.79607 ? 422  LYS   A N   1 
ATOM   3098 C CA  . LYS   A 1 440 ? -20.82631 2.69325   -6.05483  1.000 14.07008 ? 422  LYS   A CA  1 
ATOM   3099 C C   . LYS   A 1 440 ? -20.41903 1.22239   -6.07565  1.000 13.91188 ? 422  LYS   A C   1 
ATOM   3100 O O   . LYS   A 1 440 ? -20.70790 0.47779   -5.12943  1.000 14.15612 ? 422  LYS   A O   1 
ATOM   3101 C CB  . LYS   A 1 440 ? -22.18433 2.89171   -6.72851  1.000 16.41018 ? 422  LYS   A CB  1 
ATOM   3102 C CG  . LYS   A 1 440 ? -23.27898 2.05896   -6.12015  1.000 17.13497 ? 422  LYS   A CG  1 
ATOM   3103 C CD  . LYS   A 1 440 ? -23.70684 2.69424   -4.81248  1.000 23.48865 ? 422  LYS   A CD  1 
ATOM   3104 C CE  . LYS   A 1 440 ? -25.13310 2.30966   -4.45298  1.000 37.24404 ? 422  LYS   A CE  1 
ATOM   3105 N NZ  . LYS   A 1 440 ? -25.13215 1.04394   -3.66299  1.000 32.68417 ? 422  LYS   A NZ  1 
ATOM   3106 N N   . TRP   A 1 441 ? -19.76305 0.78753   -7.15984  1.000 14.20905 ? 423  TRP   A N   1 
ATOM   3107 C CA  . TRP   A 1 441 ? -19.16874 -0.54721  -7.22828  1.000 13.98827 ? 423  TRP   A CA  1 
ATOM   3108 C C   . TRP   A 1 441 ? -18.18667 -0.76647  -6.08180  1.000 14.89453 ? 423  TRP   A C   1 
ATOM   3109 O O   . TRP   A 1 441 ? -18.23833 -1.78686  -5.38309  1.000 11.67206 ? 423  TRP   A O   1 
ATOM   3110 C CB  . TRP   A 1 441 ? -18.46129 -0.68626  -8.57962  1.000 13.85078 ? 423  TRP   A CB  1 
ATOM   3111 C CG  . TRP   A 1 441 ? -17.74895 -1.95456  -8.88931  1.000 15.51615 ? 423  TRP   A CG  1 
ATOM   3112 C CD1 . TRP   A 1 441 ? -18.09851 -3.22310  -8.52078  1.000 12.86795 ? 423  TRP   A CD1 1 
ATOM   3113 C CD2 . TRP   A 1 441 ? -16.58086 -2.07975  -9.70698  1.000 13.47695 ? 423  TRP   A CD2 1 
ATOM   3114 N NE1 . TRP   A 1 441 ? -17.19774 -4.12964  -9.04251  1.000 13.27038 ? 423  TRP   A NE1 1 
ATOM   3115 C CE2 . TRP   A 1 441 ? -16.26336 -3.45080  -9.77908  1.000 15.37286 ? 423  TRP   A CE2 1 
ATOM   3116 C CE3 . TRP   A 1 441 ? -15.76561 -1.15796  -10.38276 1.000 14.22256 ? 423  TRP   A CE3 1 
ATOM   3117 C CZ2 . TRP   A 1 441 ? -15.16733 -3.92550  -10.49830 1.000 17.30507 ? 423  TRP   A CZ2 1 
ATOM   3118 C CZ3 . TRP   A 1 441 ? -14.67182 -1.63240  -11.09413 1.000 14.12538 ? 423  TRP   A CZ3 1 
ATOM   3119 C CH2 . TRP   A 1 441 ? -14.38896 -3.00403  -11.15075 1.000 13.97331 ? 423  TRP   A CH2 1 
ATOM   3120 N N   . GLU   A 1 442 ? -17.28498 0.19860   -5.87978  1.000 12.29908 ? 424  GLU   A N   1 
ATOM   3121 C CA  . GLU   A 1 442 ? -16.30965 0.14133   -4.79262  1.000 12.58123 ? 424  GLU   A CA  1 
ATOM   3122 C C   . GLU   A 1 442 ? -16.97993 0.15087   -3.42648  1.000 19.11031 ? 424  GLU   A C   1 
ATOM   3123 O O   . GLU   A 1 442 ? -16.52680 -0.53234  -2.49698  1.000 14.25644 ? 424  GLU   A O   1 
ATOM   3124 C CB  . GLU   A 1 442 ? -15.35937 1.33492   -4.88586  1.000 15.70015 ? 424  GLU   A CB  1 
ATOM   3125 C CG  . GLU   A 1 442 ? -14.41667 1.44270   -3.69396  1.000 15.44550 ? 424  GLU   A CG  1 
ATOM   3126 C CD  . GLU   A 1 442 ? -13.57876 2.69281   -3.73575  1.000 18.45519 ? 424  GLU   A CD  1 
ATOM   3127 O OE1 . GLU   A 1 442 ? -14.13398 3.78347   -3.48211  1.000 15.07638 ? 424  GLU   A OE1 1 
ATOM   3128 O OE2 . GLU   A 1 442 ? -12.36962 2.58542   -4.03112  1.000 14.57343 ? 424  GLU   A OE2 1 
ATOM   3129 N N   . GLU   A 1 443 ? -18.02961 0.95542   -3.27748  1.000 13.96352 ? 425  GLU   A N   1 
ATOM   3130 C CA  . GLU   A 1 443 ? -18.65929 1.18424   -1.98476  1.000 17.61407 ? 425  GLU   A CA  1 
ATOM   3131 C C   . GLU   A 1 443 ? -19.06112 -0.13203  -1.34584  1.000 20.61876 ? 425  GLU   A C   1 
ATOM   3132 O O   . GLU   A 1 443 ? -19.79002 -0.92772  -1.94613  1.000 18.66822 ? 425  GLU   A O   1 
ATOM   3133 C CB  . GLU   A 1 443 ? -19.87881 2.08634   -2.17065  1.000 20.05125 ? 425  GLU   A CB  1 
ATOM   3134 C CG  . GLU   A 1 443 ? -20.37992 2.75500   -0.90108  1.000 20.89708 ? 425  GLU   A CG  1 
ATOM   3135 C CD  . GLU   A 1 443 ? -21.51916 3.71456   -1.18976  1.000 25.48292 ? 425  GLU   A CD  1 
ATOM   3136 O OE1 . GLU   A 1 443 ? -21.28344 4.71330   -1.89485  1.000 20.41686 ? 425  GLU   A OE1 1 
ATOM   3137 O OE2 . GLU   A 1 443 ? -22.65278 3.45323   -0.74654  1.000 25.98574 ? 425  GLU   A OE2 1 
ATOM   3138 N N   . GLY   A 1 444 ? -18.54902 -0.37325  -0.13991  1.000 24.27809 ? 426  GLY   A N   1 
ATOM   3139 C CA  . GLY   A 1 444 ? -18.86615 -1.57961  0.59012   1.000 24.86231 ? 426  GLY   A CA  1 
ATOM   3140 C C   . GLY   A 1 444 ? -18.20505 -2.83879  0.08031   1.000 25.34575 ? 426  GLY   A C   1 
ATOM   3141 O O   . GLY   A 1 444 ? -18.52512 -3.92544  0.57135   1.000 22.88975 ? 426  GLY   A O   1 
ATOM   3142 N N   . SER   A 1 445 ? -17.28899 -2.73705  -0.88138  1.000 21.09713 ? 427  SER   A N   1 
ATOM   3143 C CA  . SER   A 1 445 ? -16.68667 -3.93414  -1.45555  1.000 25.79995 ? 427  SER   A CA  1 
ATOM   3144 C C   . SER   A 1 445 ? -15.45289 -4.35560  -0.66380  1.000 24.02322 ? 427  SER   A C   1 
ATOM   3145 O O   . SER   A 1 445 ? -14.82417 -3.54051  0.01199   1.000 22.06441 ? 427  SER   A O   1 
ATOM   3146 C CB  . SER   A 1 445 ? -16.31736 -3.68326  -2.92104  1.000 23.43146 ? 427  SER   A CB  1 
ATOM   3147 O OG  . SER   A 1 445 ? -17.48856 -3.52640  -3.71959  1.000 23.41181 ? 427  SER   A OG  1 
ATOM   3148 N N   . PRO   A 1 446 ? -15.07383 -5.63691  -0.72674  1.000 26.33530 ? 428  PRO   A N   1 
ATOM   3149 C CA  . PRO   A 1 446 ? -13.87418 -6.08472  0.00146   1.000 29.46062 ? 428  PRO   A CA  1 
ATOM   3150 C C   . PRO   A 1 446 ? -12.56150 -5.56078  -0.56594  1.000 30.49921 ? 428  PRO   A C   1 
ATOM   3151 O O   . PRO   A 1 446 ? -11.53897 -5.66578  0.11897   1.000 25.26312 ? 428  PRO   A O   1 
ATOM   3152 C CB  . PRO   A 1 446 ? -13.95170 -7.61452  -0.10743  1.000 28.37387 ? 428  PRO   A CB  1 
ATOM   3153 C CG  . PRO   A 1 446 ? -14.73263 -7.84732  -1.35024  1.000 28.23784 ? 428  PRO   A CG  1 
ATOM   3154 C CD  . PRO   A 1 446 ? -15.77914 -6.76659  -1.35687  1.000 21.82911 ? 428  PRO   A CD  1 
ATOM   3155 N N   . THR   A 1 447 ? -12.55263 -4.99457  -1.77505  1.000 21.86258 ? 429  THR   A N   1 
ATOM   3156 C CA  . THR   A 1 447 ? -11.34953 -4.49730  -2.42071  1.000 24.88321 ? 429  THR   A CA  1 
ATOM   3157 C C   . THR   A 1 447 ? -11.52177 -3.03047  -2.80973  1.000 20.07455 ? 429  THR   A C   1 
ATOM   3158 O O   . THR   A 1 447 ? -12.58991 -2.64963  -3.29575  1.000 25.36206 ? 429  THR   A O   1 
ATOM   3159 C CB  . THR   A 1 447 ? -11.04183 -5.32865  -3.68037  1.000 28.70980 ? 429  THR   A CB  1 
ATOM   3160 O OG1 . THR   A 1 447 ? -11.38824 -6.70279  -3.44598  1.000 31.97139 ? 429  THR   A OG1 1 
ATOM   3161 C CG2 . THR   A 1 447 ? -9.56764  -5.22373  -4.07176  1.000 23.32195 ? 429  THR   A CG2 1 
ATOM   3162 N N   . PRO   A 1 448 ? -10.51043 -2.18659  -2.60341  1.000 18.08158 ? 430  PRO   A N   1 
ATOM   3163 C CA  . PRO   A 1 448 ? -10.59279 -0.80918  -3.11041  1.000 18.78805 ? 430  PRO   A CA  1 
ATOM   3164 C C   . PRO   A 1 448 ? -10.51172 -0.77762  -4.62791  1.000 18.86337 ? 430  PRO   A C   1 
ATOM   3165 O O   . PRO   A 1 448 ? -9.92951  -1.66020  -5.26266  1.000 17.92150 ? 430  PRO   A O   1 
ATOM   3166 C CB  . PRO   A 1 448 ? -9.37827  -0.11015  -2.48228  1.000 23.48285 ? 430  PRO   A CB  1 
ATOM   3167 C CG  . PRO   A 1 448 ? -8.71936  -1.11974  -1.59216  1.000 31.26141 ? 430  PRO   A CG  1 
ATOM   3168 C CD  . PRO   A 1 448 ? -9.23162  -2.46710  -1.93134  1.000 24.08586 ? 430  PRO   A CD  1 
ATOM   3169 N N   . VAL   A 1 449 ? -11.09138 0.26829   -5.21016  1.000 18.59990 ? 431  VAL   A N   1 
ATOM   3170 C CA  . VAL   A 1 449 ? -11.08915 0.46843   -6.66067  1.000 17.33543 ? 431  VAL   A CA  1 
ATOM   3171 C C   . VAL   A 1 449 ? -10.26229 1.69254   -7.04781  1.000 14.83480 ? 431  VAL   A C   1 
ATOM   3172 O O   . VAL   A 1 449 ? -9.33608  1.59962   -7.85556  1.000 15.02787 ? 431  VAL   A O   1 
ATOM   3173 C CB  . VAL   A 1 449 ? -12.53096 0.57081   -7.20804  1.000 13.96590 ? 431  VAL   A CB  1 
ATOM   3174 C CG1 . VAL   A 1 449 ? -12.51347 0.98612   -8.67082  1.000 14.50633 ? 431  VAL   A CG1 1 
ATOM   3175 C CG2 . VAL   A 1 449 ? -13.25140 -0.76424  -7.04003  1.000 17.85462 ? 431  VAL   A CG2 1 
ATOM   3176 N N   . LEU   A 1 450 ? -10.58170 2.84817   -6.48088  1.000 9.85271  ? 432  LEU   A N   1 
ATOM   3177 C CA  . LEU   A 1 450 ? -9.96816  4.09686   -6.89833  1.000 12.10698 ? 432  LEU   A CA  1 
ATOM   3178 C C   . LEU   A 1 450 ? -8.65880  4.35029   -6.15950  1.000 21.08153 ? 432  LEU   A C   1 
ATOM   3179 O O   . LEU   A 1 450 ? -8.55314  4.11217   -4.95196  1.000 18.24815 ? 432  LEU   A O   1 
ATOM   3180 C CB  . LEU   A 1 450 ? -10.94933 5.24806   -6.67906  1.000 12.66926 ? 432  LEU   A CB  1 
ATOM   3181 C CG  . LEU   A 1 450 ? -12.16987 4.96765   -7.56228  1.000 20.20786 ? 432  LEU   A CG  1 
ATOM   3182 C CD1 . LEU   A 1 450 ? -13.44872 5.45311   -6.92699  1.000 19.10976 ? 432  LEU   A CD1 1 
ATOM   3183 C CD2 . LEU   A 1 450 ? -11.99771 5.53226   -8.98375  1.000 14.35603 ? 432  LEU   A CD2 1 
ATOM   3184 N N   . HIS   A 1 451 ? -7.65946  4.82532   -6.90518  1.000 12.43497 ? 433  HIS   A N   1 
ATOM   3185 C CA  . HIS   A 1 451 ? -6.35402  5.18883   -6.37127  1.000 16.38149 ? 433  HIS   A CA  1 
ATOM   3186 C C   . HIS   A 1 451 ? -5.94606  6.52155   -6.98722  1.000 14.85980 ? 433  HIS   A C   1 
ATOM   3187 O O   . HIS   A 1 451 ? -6.62227  7.04280   -7.87861  1.000 12.85030 ? 433  HIS   A O   1 
ATOM   3188 C CB  . HIS   A 1 451 ? -5.31400  4.09045   -6.64517  1.000 12.87743 ? 433  HIS   A CB  1 
ATOM   3189 C CG  . HIS   A 1 451 ? -5.71197  2.74796   -6.11305  1.000 14.64539 ? 433  HIS   A CG  1 
ATOM   3190 N ND1 . HIS   A 1 451 ? -5.60275  2.41371   -4.77983  1.000 17.86166 ? 433  HIS   A ND1 1 
ATOM   3191 C CD2 . HIS   A 1 451 ? -6.24190  1.66323   -6.72967  1.000 17.68722 ? 433  HIS   A CD2 1 
ATOM   3192 C CE1 . HIS   A 1 451 ? -6.03619  1.17763   -4.60032  1.000 17.26815 ? 433  HIS   A CE1 1 
ATOM   3193 N NE2 . HIS   A 1 451 ? -6.42877  0.69896   -5.76724  1.000 15.94001 ? 433  HIS   A NE2 1 
ATOM   3194 N N   . VAL   A 1 452 ? -4.81085  7.06488   -6.52811  1.000 16.12224 ? 434  VAL   A N   1 
ATOM   3195 C CA  . VAL   A 1 452 ? -4.47876  8.45868   -6.82809  1.000 15.57512 ? 434  VAL   A CA  1 
ATOM   3196 C C   . VAL   A 1 452 ? -4.37237  8.68636   -8.33239  1.000 18.62135 ? 434  VAL   A C   1 
ATOM   3197 O O   . VAL   A 1 452 ? -4.78760  9.73381   -8.84324  1.000 18.38400 ? 434  VAL   A O   1 
ATOM   3198 C CB  . VAL   A 1 452 ? -3.18758  8.88008   -6.09540  1.000 20.50831 ? 434  VAL   A CB  1 
ATOM   3199 C CG1 . VAL   A 1 452 ? -1.97114  8.07596   -6.58595  1.000 16.52293 ? 434  VAL   A CG1 1 
ATOM   3200 C CG2 . VAL   A 1 452 ? -2.96283  10.38875  -6.25204  1.000 24.49864 ? 434  VAL   A CG2 1 
ATOM   3201 N N   . GLY   A 1 453 ? -3.83134  7.70757   -9.06812  1.000 17.05667 ? 435  GLY   A N   1 
ATOM   3202 C CA  . GLY   A 1 453 ? -3.71863  7.84839   -10.50840 1.000 13.94134 ? 435  GLY   A CA  1 
ATOM   3203 C C   . GLY   A 1 453 ? -5.05098  8.06327   -11.20509 1.000 18.24969 ? 435  GLY   A C   1 
ATOM   3204 O O   . GLY   A 1 453 ? -5.11862  8.77568   -12.20912 1.000 15.70897 ? 435  GLY   A O   1 
ATOM   3205 N N   . TRP   A 1 454 ? -6.12225  7.44666   -10.69506 1.000 14.23197 ? 436  TRP   A N   1 
ATOM   3206 C CA  . TRP   A 1 454 ? -7.44930  7.68534   -11.26329 1.000 15.16143 ? 436  TRP   A CA  1 
ATOM   3207 C C   . TRP   A 1 454 ? -7.85365  9.14485   -11.10256 1.000 15.47883 ? 436  TRP   A C   1 
ATOM   3208 O O   . TRP   A 1 454 ? -8.52292  9.71487   -11.97171 1.000 13.44191 ? 436  TRP   A O   1 
ATOM   3209 C CB  . TRP   A 1 454 ? -8.49787  6.79921   -10.59001 1.000 11.75006 ? 436  TRP   A CB  1 
ATOM   3210 C CG  . TRP   A 1 454 ? -8.41608  5.32650   -10.81152 1.000 13.50639 ? 436  TRP   A CG  1 
ATOM   3211 C CD1 . TRP   A 1 454 ? -7.44936  4.47716   -10.35354 1.000 12.52809 ? 436  TRP   A CD1 1 
ATOM   3212 C CD2 . TRP   A 1 454 ? -9.39814  4.49929   -11.47018 1.000 11.52905 ? 436  TRP   A CD2 1 
ATOM   3213 N NE1 . TRP   A 1 454 ? -7.75127  3.18236   -10.71474 1.000 14.20189 ? 436  TRP   A NE1 1 
ATOM   3214 C CE2 . TRP   A 1 454 ? -8.94113  3.16861   -11.39651 1.000 12.77320 ? 436  TRP   A CE2 1 
ATOM   3215 C CE3 . TRP   A 1 454 ? -10.60372 4.76100   -12.12683 1.000 14.67154 ? 436  TRP   A CE3 1 
ATOM   3216 C CZ2 . TRP   A 1 454 ? -9.64501  2.10567   -11.95999 1.000 12.39663 ? 436  TRP   A CZ2 1 
ATOM   3217 C CZ3 . TRP   A 1 454 ? -11.30799 3.70176   -12.67904 1.000 15.17569 ? 436  TRP   A CZ3 1 
ATOM   3218 C CH2 . TRP   A 1 454 ? -10.82678 2.39037   -12.59188 1.000 12.92742 ? 436  TRP   A CH2 1 
ATOM   3219 N N   . ALA   A 1 455 ? -7.47981  9.76024   -9.97755  1.000 16.21200 ? 437  ALA   A N   1 
ATOM   3220 C CA  . ALA   A 1 455 ? -7.87169  11.14316  -9.73953  1.000 19.01166 ? 437  ALA   A CA  1 
ATOM   3221 C C   . ALA   A 1 455 ? -7.18072  12.09266  -10.70704 1.000 17.35158 ? 437  ALA   A C   1 
ATOM   3222 O O   . ALA   A 1 455 ? -7.75735  13.12123  -11.08944 1.000 13.14402 ? 437  ALA   A O   1 
ATOM   3223 C CB  . ALA   A 1 455 ? -7.57169  11.52280  -8.29078  1.000 18.45455 ? 437  ALA   A CB  1 
ATOM   3224 N N   . THR   A 1 456 ? -5.95946  11.76314  -11.12680 1.000 12.76714 ? 438  THR   A N   1 
ATOM   3225 C CA  . THR   A 1 456 ? -5.26097  12.60716  -12.09183 1.000 16.79133 ? 438  THR   A CA  1 
ATOM   3226 C C   . THR   A 1 456 ? -6.02425  12.66729  -13.40684 1.000 15.78491 ? 438  THR   A C   1 
ATOM   3227 O O   . THR   A 1 456 ? -6.18306  13.74116  -14.00206 1.000 16.96406 ? 438  THR   A O   1 
ATOM   3228 C CB  . THR   A 1 456 ? -3.84174  12.07813  -12.32774 1.000 22.22871 ? 438  THR   A CB  1 
ATOM   3229 O OG1 . THR   A 1 456 ? -3.11106  12.08109  -11.09354 1.000 22.69578 ? 438  THR   A OG1 1 
ATOM   3230 C CG2 . THR   A 1 456 ? -3.11339  12.93404  -13.35883 1.000 26.05325 ? 438  THR   A CG2 1 
ATOM   3231 N N   . PHE   A 1 457 ? -6.51980  11.52413  -13.87162 1.000 15.86849 ? 439  PHE   A N   1 
ATOM   3232 C CA  . PHE   A 1 457 ? -7.24103  11.52770  -15.13449 1.000 14.91204 ? 439  PHE   A CA  1 
ATOM   3233 C C   . PHE   A 1 457 ? -8.64872  12.09346  -14.98284 1.000 14.11010 ? 439  PHE   A C   1 
ATOM   3234 O O   . PHE   A 1 457 ? -9.14332  12.73787  -15.91289 1.000 12.13056 ? 439  PHE   A O   1 
ATOM   3235 C CB  . PHE   A 1 457 ? -7.24077  10.11900  -15.72210 1.000 12.85434 ? 439  PHE   A CB  1 
ATOM   3236 C CG  . PHE   A 1 457 ? -5.88875  9.69848   -16.21793 1.000 16.91761 ? 439  PHE   A CG  1 
ATOM   3237 C CD1 . PHE   A 1 457 ? -5.36047  10.26243  -17.36731 1.000 23.71873 ? 439  PHE   A CD1 1 
ATOM   3238 C CD2 . PHE   A 1 457 ? -5.11612  8.80225   -15.50146 1.000 20.85015 ? 439  PHE   A CD2 1 
ATOM   3239 C CE1 . PHE   A 1 457 ? -4.10880  9.90668   -17.81745 1.000 20.08022 ? 439  PHE   A CE1 1 
ATOM   3240 C CE2 . PHE   A 1 457 ? -3.85854  8.44020   -15.95215 1.000 21.97038 ? 439  PHE   A CE2 1 
ATOM   3241 C CZ  . PHE   A 1 457 ? -3.35565  8.99679   -17.10572 1.000 15.32862 ? 439  PHE   A CZ  1 
ATOM   3242 N N   . LEU   A 1 458 ? -9.28982  11.90605  -13.82369 1.000 11.19308 ? 440  LEU   A N   1 
ATOM   3243 C CA  . LEU   A 1 458 ? -10.58919 12.53877  -13.59284 1.000 14.05760 ? 440  LEU   A CA  1 
ATOM   3244 C C   . LEU   A 1 458 ? -10.47404 14.05733  -13.67291 1.000 11.02949 ? 440  LEU   A C   1 
ATOM   3245 O O   . LEU   A 1 458 ? -11.24527 14.71545  -14.38557 1.000 14.44615 ? 440  LEU   A O   1 
ATOM   3246 C CB  . LEU   A 1 458 ? -11.16303 12.12151  -12.23206 1.000 10.69102 ? 440  LEU   A CB  1 
ATOM   3247 C CG  . LEU   A 1 458 ? -12.38877 12.92172  -11.75536 1.000 10.15433 ? 440  LEU   A CG  1 
ATOM   3248 C CD1 . LEU   A 1 458 ? -13.56231 12.76424  -12.72935 1.000 12.83943 ? 440  LEU   A CD1 1 
ATOM   3249 C CD2 . LEU   A 1 458 ? -12.81129 12.52933  -10.33365 1.000 13.54549 ? 440  LEU   A CD2 1 
ATOM   3250 N N   . VAL   A 1 459 ? -9.50023  14.63164  -12.95819 1.000 9.70671  ? 441  VAL   A N   1 
ATOM   3251 C CA  . VAL   A 1 459 ? -9.30213  16.08268  -12.98879 1.000 13.04316 ? 441  VAL   A CA  1 
ATOM   3252 C C   . VAL   A 1 459 ? -9.08280  16.56577  -14.41847 1.000 16.10911 ? 441  VAL   A C   1 
ATOM   3253 O O   . VAL   A 1 459 ? -9.61376  17.60870  -14.83565 1.000 16.29122 ? 441  VAL   A O   1 
ATOM   3254 C CB  . VAL   A 1 459 ? -8.13358  16.47931  -12.06785 1.000 14.77167 ? 441  VAL   A CB  1 
ATOM   3255 C CG1 . VAL   A 1 459 ? -7.65391  17.90182  -12.37328 1.000 17.62101 ? 441  VAL   A CG1 1 
ATOM   3256 C CG2 . VAL   A 1 459 ? -8.54105  16.32520  -10.60148 1.000 15.32863 ? 441  VAL   A CG2 1 
ATOM   3257 N N   . GLN   A 1 460 ? -8.31611  15.80724  -15.19517 1.000 13.58775 ? 442  GLN   A N   1 
ATOM   3258 C CA  . GLN   A 1 460 ? -8.05832  16.16841  -16.58453 1.000 14.91667 ? 442  GLN   A CA  1 
ATOM   3259 C C   . GLN   A 1 460 ? -9.32998  16.07188  -17.42938 1.000 16.27491 ? 442  GLN   A C   1 
ATOM   3260 O O   . GLN   A 1 460 ? -9.60025  16.94938  -18.25441 1.000 16.06809 ? 442  GLN   A O   1 
ATOM   3261 C CB  . GLN   A 1 460 ? -6.94928  15.26651  -17.12502 1.000 17.04479 ? 442  GLN   A CB  1 
ATOM   3262 C CG  . GLN   A 1 460 ? -6.60571  15.44043  -18.57743 1.000 19.23742 ? 442  GLN   A CG  1 
ATOM   3263 C CD  . GLN   A 1 460 ? -5.63745  14.36723  -19.06534 1.000 22.78401 ? 442  GLN   A CD  1 
ATOM   3264 O OE1 . GLN   A 1 460 ? -6.05544  13.30387  -19.51145 1.000 18.88698 ? 442  GLN   A OE1 1 
ATOM   3265 N NE2 . GLN   A 1 460 ? -4.33407  14.64712  -18.97688 1.000 27.96130 ? 442  GLN   A NE2 1 
ATOM   3266 N N   . SER   A 1 461 ? -10.14514 15.03375  -17.21500 1.000 14.08930 ? 443  SER   A N   1 
ATOM   3267 C CA  . SER   A 1 461 ? -11.37107 14.89304  -17.99799 1.000 14.35496 ? 443  SER   A CA  1 
ATOM   3268 C C   . SER   A 1 461 ? -12.41292 15.94244  -17.60460 1.000 15.09171 ? 443  SER   A C   1 
ATOM   3269 O O   . SER   A 1 461 ? -13.13951 16.45201  -18.46477 1.000 13.34852 ? 443  SER   A O   1 
ATOM   3270 C CB  . SER   A 1 461 ? -11.93510 13.47682  -17.85113 1.000 14.18427 ? 443  SER   A CB  1 
ATOM   3271 O OG  . SER   A 1 461 ? -11.07771 12.49919  -18.45555 1.000 12.74242 ? 443  SER   A OG  1 
ATOM   3272 N N   . LEU   A 1 462 ? -12.51979 16.26807  -16.31405 1.000 12.47392 ? 444  LEU   A N   1 
ATOM   3273 C CA  . LEU   A 1 462 ? -13.39115 17.37036  -15.91030 1.000 13.47553 ? 444  LEU   A CA  1 
ATOM   3274 C C   . LEU   A 1 462 ? -13.00274 18.65702  -16.62847 1.000 18.11856 ? 444  LEU   A C   1 
ATOM   3275 O O   . LEU   A 1 462 ? -13.86214 19.38157  -17.14443 1.000 18.02933 ? 444  LEU   A O   1 
ATOM   3276 C CB  . LEU   A 1 462 ? -13.32645 17.57152  -14.39791 1.000 12.92574 ? 444  LEU   A CB  1 
ATOM   3277 C CG  . LEU   A 1 462 ? -13.83360 16.42998  -13.52065 1.000 14.43322 ? 444  LEU   A CG  1 
ATOM   3278 C CD1 . LEU   A 1 462 ? -13.50544 16.69639  -12.05827 1.000 13.12685 ? 444  LEU   A CD1 1 
ATOM   3279 C CD2 . LEU   A 1 462 ? -15.34293 16.26277  -13.71321 1.000 12.75885 ? 444  LEU   A CD2 1 
ATOM   3280 N N   . GLY   A 1 463 ? -11.70103 18.94707  -16.68476 1.000 11.55768 ? 445  GLY   A N   1 
ATOM   3281 C CA  . GLY   A 1 463 ? -11.23616 20.18538  -17.28739 1.000 12.04691 ? 445  GLY   A CA  1 
ATOM   3282 C C   . GLY   A 1 463 ? -11.54485 20.31401  -18.76222 1.000 18.68445 ? 445  GLY   A C   1 
ATOM   3283 O O   . GLY   A 1 463 ? -11.57614 21.43255  -19.28060 1.000 16.95869 ? 445  GLY   A O   1 
ATOM   3284 N N   . ARG   A 1 464 ? -11.77676 19.19674  -19.45259 1.000 13.27423 ? 446  ARG   A N   1 
ATOM   3285 C CA  . ARG   A 1 464 ? -12.15889 19.24307  -20.85742 1.000 16.72810 ? 446  ARG   A CA  1 
ATOM   3286 C C   . ARG   A 1 464 ? -13.51079 19.91675  -21.06531 1.000 19.80517 ? 446  ARG   A C   1 
ATOM   3287 O O   . ARG   A 1 464 ? -13.83935 20.29107  -22.19622 1.000 20.87222 ? 446  ARG   A O   1 
ATOM   3288 C CB  . ARG   A 1 464 ? -12.19107 17.82358  -21.43887 1.000 19.37187 ? 446  ARG   A CB  1 
ATOM   3289 C CG  . ARG   A 1 464 ? -10.80322 17.19183  -21.62506 1.000 18.46388 ? 446  ARG   A CG  1 
ATOM   3290 C CD  . ARG   A 1 464 ? -10.02416 17.92619  -22.69745 1.000 16.79329 ? 446  ARG   A CD  1 
ATOM   3291 N NE  . ARG   A 1 464 ? -8.77514  17.25526  -23.03942 1.000 21.25120 ? 446  ARG   A NE  1 
ATOM   3292 C CZ  . ARG   A 1 464 ? -7.82366  17.80749  -23.77861 1.000 24.03249 ? 446  ARG   A CZ  1 
ATOM   3293 N NH1 . ARG   A 1 464 ? -7.94908  19.04265  -24.25374 1.000 17.57041 ? 446  ARG   A NH1 1 
ATOM   3294 N NH2 . ARG   A 1 464 ? -6.72417  17.10444  -24.05415 1.000 23.14876 ? 446  ARG   A NH2 1 
ATOM   3295 N N   . PHE   A 1 465 ? -14.30109 20.06640  -20.00867 1.000 16.59659 ? 447  PHE   A N   1 
ATOM   3296 C CA  . PHE   A 1 465 ? -15.60774 20.70496  -20.07069 1.000 17.16150 ? 447  PHE   A CA  1 
ATOM   3297 C C   . PHE   A 1 465 ? -15.49570 22.04520  -19.36851 1.000 18.21724 ? 447  PHE   A C   1 
ATOM   3298 O O   . PHE   A 1 465 ? -15.16675 22.09881  -18.17830 1.000 18.49169 ? 447  PHE   A O   1 
ATOM   3299 C CB  . PHE   A 1 465 ? -16.68467 19.84020  -19.40744 1.000 14.20142 ? 447  PHE   A CB  1 
ATOM   3300 C CG  . PHE   A 1 465 ? -16.90919 18.52159  -20.08572 1.000 12.41449 ? 447  PHE   A CG  1 
ATOM   3301 C CD1 . PHE   A 1 465 ? -16.14912 17.41523  -19.74586 1.000 17.75070 ? 447  PHE   A CD1 1 
ATOM   3302 C CD2 . PHE   A 1 465 ? -17.88658 18.38768  -21.06688 1.000 13.49422 ? 447  PHE   A CD2 1 
ATOM   3303 C CE1 . PHE   A 1 465 ? -16.35641 16.19464  -20.37102 1.000 13.25510 ? 447  PHE   A CE1 1 
ATOM   3304 C CE2 . PHE   A 1 465 ? -18.10899 17.17956  -21.69223 1.000 10.23362 ? 447  PHE   A CE2 1 
ATOM   3305 C CZ  . PHE   A 1 465 ? -17.33940 16.07054  -21.34325 1.000 11.75396 ? 447  PHE   A CZ  1 
ATOM   3306 N N   . GLU   A 1 466 ? -15.75046 23.11690  -20.11019 1.000 18.53470 ? 448  GLU   A N   1 
ATOM   3307 C CA  . GLU   A 1 466 ? -15.71513 24.45529  -19.54205 1.000 25.30876 ? 448  GLU   A CA  1 
ATOM   3308 C C   . GLU   A 1 466 ? -16.66211 24.56255  -18.35164 1.000 20.10309 ? 448  GLU   A C   1 
ATOM   3309 O O   . GLU   A 1 466 ? -17.70319 23.89909  -18.29155 1.000 15.88571 ? 448  GLU   A O   1 
ATOM   3310 C CB  . GLU   A 1 466 ? -16.09042 25.47480  -20.61347 1.000 25.05269 ? 448  GLU   A CB  1 
ATOM   3311 C CG  . GLU   A 1 466 ? -15.41556 25.23821  -21.96192 1.000 44.57823 ? 448  GLU   A CG  1 
ATOM   3312 C CD  . GLU   A 1 466 ? -16.32077 24.51909  -22.96839 1.000 58.21034 ? 448  GLU   A CD  1 
ATOM   3313 O OE1 . GLU   A 1 466 ? -16.52947 23.28092  -22.81396 1.000 26.21815 ? 448  GLU   A OE1 1 
ATOM   3314 O OE2 . GLU   A 1 466 ? -16.82746 25.19599  -23.90084 1.000 43.54794 ? 448  GLU   A OE2 1 
ATOM   3315 N N   . GLY   A 1 467 ? -16.28502 25.41326  -17.39487 1.000 20.63359 ? 449  GLY   A N   1 
ATOM   3316 C CA  . GLY   A 1 467 ? -17.10003 25.58601  -16.20548 1.000 24.17192 ? 449  GLY   A CA  1 
ATOM   3317 C C   . GLY   A 1 467 ? -18.53113 25.96332  -16.52462 1.000 22.69387 ? 449  GLY   A C   1 
ATOM   3318 O O   . GLY   A 1 467 ? -19.46270 25.53014  -15.84601 1.000 23.29453 ? 449  GLY   A O   1 
ATOM   3319 N N   . GLN   A 1 468 ? -18.72883 26.75713  -17.57856 1.000 19.28232 ? 450  GLN   A N   1 
ATOM   3320 C CA  . GLN   A 1 468 ? -20.07750 27.17067  -17.94896 1.000 23.94017 ? 450  GLN   A CA  1 
ATOM   3321 C C   . GLN   A 1 468 ? -20.91720 25.98619  -18.41268 1.000 28.02132 ? 450  GLN   A C   1 
ATOM   3322 O O   . GLN   A 1 468 ? -22.13810 25.98006  -18.22205 1.000 16.90687 ? 450  GLN   A O   1 
ATOM   3323 C CB  . GLN   A 1 468 ? -20.03451 28.26219  -19.02621 1.000 28.38006 ? 450  GLN   A CB  1 
ATOM   3324 C CG  . GLN   A 1 468 ? -18.87308 29.29557  -18.92025 1.000 42.31101 ? 450  GLN   A CG  1 
ATOM   3325 C CD  . GLN   A 1 468 ? -17.47254 28.73806  -19.21262 1.000 54.85882 ? 450  GLN   A CD  1 
ATOM   3326 O OE1 . GLN   A 1 468 ? -17.22623 28.18576  -20.28567 1.000 50.46799 ? 450  GLN   A OE1 1 
ATOM   3327 N NE2 . GLN   A 1 468 ? -16.55220 28.89376  -18.25681 1.000 41.27222 ? 450  GLN   A NE2 1 
ATOM   3328 N N   . VAL   A 1 469 ? -20.28276 24.97451  -19.00144 1.000 17.30676 ? 451  VAL   A N   1 
ATOM   3329 C CA  . VAL   A 1 469 ? -20.98639 23.74735  -19.35595 1.000 16.98014 ? 451  VAL   A CA  1 
ATOM   3330 C C   . VAL   A 1 469 ? -21.24939 22.91138  -18.10694 1.000 19.49945 ? 451  VAL   A C   1 
ATOM   3331 O O   . VAL   A 1 469 ? -22.36376 22.42169  -17.88279 1.000 14.20944 ? 451  VAL   A O   1 
ATOM   3332 C CB  . VAL   A 1 469 ? -20.16653 22.97103  -20.40302 1.000 16.02906 ? 451  VAL   A CB  1 
ATOM   3333 C CG1 . VAL   A 1 469 ? -20.79201 21.61101  -20.71299 1.000 14.84217 ? 451  VAL   A CG1 1 
ATOM   3334 C CG2 . VAL   A 1 469 ? -19.99793 23.82141  -21.67075 1.000 19.39254 ? 451  VAL   A CG2 1 
ATOM   3335 N N   . ARG   A 1 470 ? -20.22337 22.74505  -17.26873 1.000 13.65255 ? 452  ARG   A N   1 
ATOM   3336 C CA  . ARG   A 1 470 ? -20.35480 21.91709  -16.07330 1.000 13.97492 ? 452  ARG   A CA  1 
ATOM   3337 C C   . ARG   A 1 470 ? -21.42109 22.44239  -15.11987 1.000 16.03896 ? 452  ARG   A C   1 
ATOM   3338 O O   . ARG   A 1 470 ? -22.10789 21.65215  -14.46426 1.000 14.10570 ? 452  ARG   A O   1 
ATOM   3339 C CB  . ARG   A 1 470 ? -19.00864 21.82817  -15.36081 1.000 12.05394 ? 452  ARG   A CB  1 
ATOM   3340 C CG  . ARG   A 1 470 ? -17.92899 21.14024  -16.20775 1.000 15.73702 ? 452  ARG   A CG  1 
ATOM   3341 C CD  . ARG   A 1 470 ? -16.66385 20.86561  -15.41303 1.000 13.88045 ? 452  ARG   A CD  1 
ATOM   3342 N NE  . ARG   A 1 470 ? -15.78794 22.02868  -15.35853 1.000 19.48214 ? 452  ARG   A NE  1 
ATOM   3343 C CZ  . ARG   A 1 470 ? -15.63466 22.79262  -14.28697 1.000 27.03396 ? 452  ARG   A CZ  1 
ATOM   3344 N NH1 . ARG   A 1 470 ? -16.26131 22.52212  -13.15416 1.000 26.77353 ? 452  ARG   A NH1 1 
ATOM   3345 N NH2 . ARG   A 1 470 ? -14.84144 23.86052  -14.35652 1.000 23.82620 ? 452  ARG   A NH2 1 
ATOM   3346 N N   . GLN   A 1 471 ? -21.58087 23.75725  -15.03184 1.000 13.66613 ? 453  GLN   A N   1 
ATOM   3347 C CA  . GLN   A 1 471 ? -22.53531 24.36343  -14.10471 1.000 14.52634 ? 453  GLN   A CA  1 
ATOM   3348 C C   . GLN   A 1 471 ? -23.98534 24.23552  -14.55312 1.000 16.58282 ? 453  GLN   A C   1 
ATOM   3349 O O   . GLN   A 1 471 ? -24.88022 24.67715  -13.82896 1.000 16.87462 ? 453  GLN   A O   1 
ATOM   3350 C CB  . GLN   A 1 471 ? -22.17998 25.84048  -13.87994 1.000 22.26227 ? 453  GLN   A CB  1 
ATOM   3351 C CG  . GLN   A 1 471 ? -20.90361 26.00967  -13.06843 1.000 29.81604 ? 453  GLN   A CG  1 
ATOM   3352 C CD  . GLN   A 1 471 ? -20.33662 27.41891  -13.08171 1.000 42.80141 ? 453  GLN   A CD  1 
ATOM   3353 O OE1 . GLN   A 1 471 ? -19.18333 27.63045  -12.70360 1.000 50.16603 ? 453  GLN   A OE1 1 
ATOM   3354 N NE2 . GLN   A 1 471 ? -21.13774 28.38653  -13.51137 1.000 48.20804 ? 453  GLN   A NE2 1 
ATOM   3355 N N   . LYS   A 1 472 ? -24.24634 23.62711  -15.70313 1.000 16.71793 ? 454  LYS   A N   1 
ATOM   3356 C CA  . LYS   A 1 472 ? -25.60843 23.46880  -16.18504 1.000 17.05456 ? 454  LYS   A CA  1 
ATOM   3357 C C   . LYS   A 1 472 ? -26.26466 22.18004  -15.71190 1.000 20.78166 ? 454  LYS   A C   1 
ATOM   3358 O O   . LYS   A 1 472 ? -27.49162 22.06570  -15.78580 1.000 19.13957 ? 454  LYS   A O   1 
ATOM   3359 C CB  . LYS   A 1 472 ? -25.61864 23.51059  -17.71502 1.000 18.39181 ? 454  LYS   A CB  1 
ATOM   3360 C CG  . LYS   A 1 472 ? -25.43776 24.92079  -18.28972 1.000 21.01180 ? 454  LYS   A CG  1 
ATOM   3361 C CD  . LYS   A 1 472 ? -25.58872 24.92670  -19.80412 1.000 22.31257 ? 454  LYS   A CD  1 
ATOM   3362 C CE  . LYS   A 1 472 ? -24.63674 25.93717  -20.44364 1.000 35.29417 ? 454  LYS   A CE  1 
ATOM   3363 N NZ  . LYS   A 1 472 ? -24.02763 25.41713  -21.70620 1.000 43.01279 ? 454  LYS   A NZ  1 
ATOM   3364 N N   . VAL   A 1 473 ? -25.49575 21.19952  -15.24118 1.000 13.26832 ? 455  VAL   A N   1 
ATOM   3365 C CA  . VAL   A 1 473 ? -26.10219 19.93086  -14.85476 1.000 10.57570 ? 455  VAL   A CA  1 
ATOM   3366 C C   . VAL   A 1 473 ? -26.72976 20.04387  -13.46997 1.000 16.46047 ? 455  VAL   A C   1 
ATOM   3367 O O   . VAL   A 1 473 ? -26.28606 20.81830  -12.61398 1.000 16.45435 ? 455  VAL   A O   1 
ATOM   3368 C CB  . VAL   A 1 473 ? -25.07339 18.78233  -14.90150 1.000 14.35957 ? 455  VAL   A CB  1 
ATOM   3369 C CG1 . VAL   A 1 473 ? -24.41156 18.69076  -16.28278 1.000 12.17746 ? 455  VAL   A CG1 1 
ATOM   3370 C CG2 . VAL   A 1 473 ? -24.04096 18.94240  -13.79849 1.000 14.76168 ? 455  VAL   A CG2 1 
ATOM   3371 N N   . ARG   A 1 474 ? -27.79037 19.26318  -13.25975 1.000 11.36046 ? 456  ARG   A N   1 
ATOM   3372 C CA  . ARG   A 1 474 ? -28.38513 19.01835  -11.94464 1.000 11.47572 ? 456  ARG   A CA  1 
ATOM   3373 C C   . ARG   A 1 474 ? -28.55357 17.50658  -11.86381 1.000 12.60210 ? 456  ARG   A C   1 
ATOM   3374 O O   . ARG   A 1 474 ? -29.43519 16.93769  -12.51350 1.000 11.39440 ? 456  ARG   A O   1 
ATOM   3375 C CB  . ARG   A 1 474 ? -29.72061 19.74764  -11.76420 1.000 13.55660 ? 456  ARG   A CB  1 
ATOM   3376 C CG  . ARG   A 1 474 ? -29.67080 21.24255  -12.04736 1.000 18.02085 ? 456  ARG   A CG  1 
ATOM   3377 C CD  . ARG   A 1 474 ? -28.96095 21.99653  -10.94072 1.000 21.26351 ? 456  ARG   A CD  1 
ATOM   3378 N NE  . ARG   A 1 474 ? -29.00876 23.43738  -11.15663 1.000 25.78362 ? 456  ARG   A NE  1 
ATOM   3379 C CZ  . ARG   A 1 474 ? -28.09813 24.12264  -11.83693 1.000 40.74166 ? 456  ARG   A CZ  1 
ATOM   3380 N NH1 . ARG   A 1 474 ? -27.04713 23.52799  -12.38182 1.000 21.41987 ? 456  ARG   A NH1 1 
ATOM   3381 N NH2 . ARG   A 1 474 ? -28.24287 25.43832  -11.97229 1.000 34.54801 ? 456  ARG   A NH2 1 
ATOM   3382 N N   . ILE   A 1 475 ? -27.69346 16.85170  -11.09572 1.000 13.32298 ? 457  ILE   A N   1 
ATOM   3383 C CA  . ILE   A 1 475 ? -27.58327 15.39821  -11.12294 1.000 13.72207 ? 457  ILE   A CA  1 
ATOM   3384 C C   . ILE   A 1 475 ? -27.78112 14.87965  -9.70703  1.000 14.41603 ? 457  ILE   A C   1 
ATOM   3385 O O   . ILE   A 1 475 ? -27.48680 15.58079  -8.73547  1.000 20.72179 ? 457  ILE   A O   1 
ATOM   3386 C CB  . ILE   A 1 475 ? -26.20716 14.96031  -11.68163 1.000 14.35367 ? 457  ILE   A CB  1 
ATOM   3387 C CG1 . ILE   A 1 475 ? -26.19844 14.99236  -13.20159 1.000 22.29926 ? 457  ILE   A CG1 1 
ATOM   3388 C CG2 . ILE   A 1 475 ? -25.79983 13.55944  -11.22945 1.000 23.90986 ? 457  ILE   A CG2 1 
ATOM   3389 C CD1 . ILE   A 1 475 ? -24.86139 15.45256  -13.74203 1.000 25.01059 ? 457  ILE   A CD1 1 
ATOM   3390 N N   . THR   A 1 476 ? -28.30220 13.66014  -9.58525  1.000 14.80463 ? 552  THR   A N   1 
ATOM   3391 C CA  . THR   A 1 476 ? -28.25601 12.93492  -8.32030  1.000 19.22693 ? 552  THR   A CA  1 
ATOM   3392 C C   . THR   A 1 476 ? -27.31175 11.75151  -8.46047  1.000 21.83126 ? 552  THR   A C   1 
ATOM   3393 O O   . THR   A 1 476 ? -27.34023 11.03489  -9.46801  1.000 19.99096 ? 552  THR   A O   1 
ATOM   3394 C CB  . THR   A 1 476 ? -29.62504 12.42200  -7.87177  1.000 30.26130 ? 552  THR   A CB  1 
ATOM   3395 O OG1 . THR   A 1 476 ? -29.94871 11.22656  -8.59090  1.000 42.95172 ? 552  THR   A OG1 1 
ATOM   3396 C CG2 . THR   A 1 476 ? -30.69002 13.44742  -8.09078  1.000 17.99176 ? 552  THR   A CG2 1 
ATOM   3397 N N   . PHE   A 1 477 ? -26.47233 11.56317  -7.45368  1.000 17.61000 ? 553  PHE   A N   1 
ATOM   3398 C CA  . PHE   A 1 477 ? -25.51098 10.47458  -7.42812  1.000 11.46949 ? 553  PHE   A CA  1 
ATOM   3399 C C   . PHE   A 1 477 ? -26.01576 9.34710   -6.53537  1.000 19.56332 ? 553  PHE   A C   1 
ATOM   3400 O O   . PHE   A 1 477 ? -26.75453 9.58635   -5.57978  1.000 17.29177 ? 553  PHE   A O   1 
ATOM   3401 C CB  . PHE   A 1 477 ? -24.16453 10.98864  -6.91722  1.000 13.23074 ? 553  PHE   A CB  1 
ATOM   3402 C CG  . PHE   A 1 477 ? -23.43201 11.84577  -7.90828  1.000 17.52765 ? 553  PHE   A CG  1 
ATOM   3403 C CD1 . PHE   A 1 477 ? -23.18302 11.38678  -9.19153  1.000 14.98293 ? 553  PHE   A CD1 1 
ATOM   3404 C CD2 . PHE   A 1 477 ? -22.99685 13.11564  -7.56092  1.000 18.39797 ? 553  PHE   A CD2 1 
ATOM   3405 C CE1 . PHE   A 1 477 ? -22.50160 12.18016  -10.10303 1.000 21.18895 ? 553  PHE   A CE1 1 
ATOM   3406 C CE2 . PHE   A 1 477 ? -22.31275 13.90761  -8.46711  1.000 24.81228 ? 553  PHE   A CE2 1 
ATOM   3407 C CZ  . PHE   A 1 477 ? -22.05909 13.43833  -9.73510  1.000 16.25339 ? 553  PHE   A CZ  1 
ATOM   3408 N N   . GLN   A 1 478 ? -25.61093 8.11013   -6.85782  1.000 14.43965 ? 554  GLN   A N   1 
ATOM   3409 C CA  . GLN   A 1 478 ? -25.83285 6.96140   -5.98226  1.000 14.44543 ? 554  GLN   A CA  1 
ATOM   3410 C C   . GLN   A 1 478 ? -24.73074 6.78207   -4.94540  1.000 15.71167 ? 554  GLN   A C   1 
ATOM   3411 O O   . GLN   A 1 478 ? -25.00598 6.36847   -3.81402  1.000 15.76062 ? 554  GLN   A O   1 
ATOM   3412 C CB  . GLN   A 1 478 ? -25.94238 5.67277   -6.80100  1.000 18.30171 ? 554  GLN   A CB  1 
ATOM   3413 C CG  . GLN   A 1 478 ? -26.90056 5.71211   -7.96852  1.000 33.19428 ? 554  GLN   A CG  1 
ATOM   3414 C CD  . GLN   A 1 478 ? -28.29729 6.04230   -7.52080  1.000 39.00510 ? 554  GLN   A CD  1 
ATOM   3415 O OE1 . GLN   A 1 478 ? -28.87352 5.32420   -6.70371  1.000 34.23209 ? 554  GLN   A OE1 1 
ATOM   3416 N NE2 . GLN   A 1 478 ? -28.86527 7.11745   -8.06421  1.000 31.62173 ? 554  GLN   A NE2 1 
ATOM   3417 N N   . SER   A 1 479 ? -23.47989 7.04503   -5.31361  1.000 13.05946 ? 555  SER   A N   1 
ATOM   3418 C CA  . SER   A 1 479 ? -22.35915 6.71140   -4.44583  1.000 13.22857 ? 555  SER   A CA  1 
ATOM   3419 C C   . SER   A 1 479 ? -22.12154 7.81133   -3.42123  1.000 13.24451 ? 555  SER   A C   1 
ATOM   3420 O O   . SER   A 1 479 ? -22.26938 9.00369   -3.71719  1.000 13.77604 ? 555  SER   A O   1 
ATOM   3421 C CB  . SER   A 1 479 ? -21.09421 6.48136   -5.27754  1.000 11.36897 ? 555  SER   A CB  1 
ATOM   3422 O OG  . SER   A 1 479 ? -20.59188 7.70120   -5.80374  1.000 12.34225 ? 555  SER   A OG  1 
ATOM   3423 N N   . GLU   A 1 480 ? -21.75073 7.40551   -2.20312  1.000 11.33239 ? 556  GLU   A N   1 
ATOM   3424 C CA  . GLU   A 1 480 ? -21.36841 8.38696   -1.19494  1.000 16.54973 ? 556  GLU   A CA  1 
ATOM   3425 C C   . GLU   A 1 480 ? -20.15966 9.18995   -1.64238  1.000 13.65159 ? 556  GLU   A C   1 
ATOM   3426 O O   . GLU   A 1 480 ? -20.02850 10.37297  -1.30551  1.000 12.88732 ? 556  GLU   A O   1 
ATOM   3427 C CB  . GLU   A 1 480 ? -21.03945 7.70804   0.13565   1.000 21.98912 ? 556  GLU   A CB  1 
ATOM   3428 C CG  . GLU   A 1 480 ? -22.17854 7.63871   1.11198   1.000 27.47073 ? 556  GLU   A CG  1 
ATOM   3429 C CD  . GLU   A 1 480 ? -22.00705 6.50425   2.09851   1.000 41.43845 ? 556  GLU   A CD  1 
ATOM   3430 O OE1 . GLU   A 1 480 ? -20.85217 6.02135   2.26802   1.000 25.62698 ? 556  GLU   A OE1 1 
ATOM   3431 O OE2 . GLU   A 1 480 ? -23.02552 6.11417   2.71071   1.000 28.01715 ? 556  GLU   A OE2 1 
ATOM   3432 N N   . LYS   A 1 481 ? -19.23262 8.54577   -2.35532  1.000 10.24791 ? 557  LYS   A N   1 
ATOM   3433 C CA  . LYS   A 1 481 ? -18.01741 9.23890   -2.77394  1.000 10.27174 ? 557  LYS   A CA  1 
ATOM   3434 C C   . LYS   A 1 481 ? -18.33680 10.39418  -3.71688  1.000 12.69076 ? 557  LYS   A C   1 
ATOM   3435 O O   . LYS   A 1 481 ? -17.72276 11.46914  -3.63360  1.000 12.50035 ? 557  LYS   A O   1 
ATOM   3436 C CB  . LYS   A 1 481 ? -17.05795 8.25060   -3.43483  1.000 12.24032 ? 557  LYS   A CB  1 
ATOM   3437 C CG  . LYS   A 1 481 ? -15.67832 8.80117   -3.73930  1.000 17.90137 ? 557  LYS   A CG  1 
ATOM   3438 C CD  . LYS   A 1 481 ? -14.71265 7.64562   -3.96788  1.000 12.25384 ? 557  LYS   A CD  1 
ATOM   3439 C CE  . LYS   A 1 481 ? -14.14433 7.19540   -2.61786  1.000 16.12440 ? 557  LYS   A CE  1 
ATOM   3440 N NZ  . LYS   A 1 481 ? -12.92183 6.35121   -2.74225  1.000 11.57434 ? 557  LYS   A NZ  1 
ATOM   3441 N N   . MET   A 1 482 ? -19.30294 10.19852  -4.61320  1.000 9.31346  ? 558  MET   A N   1 
ATOM   3442 C CA  . MET   A 1 482 ? -19.57339 11.21659  -5.61404  1.000 13.42792 ? 558  MET   A CA  1 
ATOM   3443 C C   . MET   A 1 482 ? -20.46616 12.29577  -4.99527  1.000 12.09214 ? 558  MET   A C   1 
ATOM   3444 O O   . MET   A 1 482 ? -20.28347 13.49576  -5.24273  1.000 12.76696 ? 558  MET   A O   1 
ATOM   3445 C CB  . MET   A 1 482 ? -20.26240 10.55239  -6.80459  1.000 17.41352 ? 558  MET   A CB  1 
ATOM   3446 C CG  . MET   A 1 482 ? -19.27785 9.95335   -7.83830  1.000 15.14703 ? 558  MET   A CG  1 
ATOM   3447 S SD  . MET   A 1 482 ? -17.82387 10.83217  -8.40051  1.000 14.88928 ? 558  MET   A SD  1 
ATOM   3448 C CE  . MET   A 1 482 ? -18.52975 11.75501  -9.75561  1.000 15.92528 ? 558  MET   A CE  1 
ATOM   3449 N N   . LYS   A 1 483 ? -21.42670 11.86728  -4.16276  1.000 9.96567  ? 559  LYS   A N   1 
ATOM   3450 C CA  . LYS   A 1 483 ? -22.20913 12.80011  -3.35046  1.000 16.60624 ? 559  LYS   A CA  1 
ATOM   3451 C C   . LYS   A 1 483 ? -21.30082 13.75551  -2.59509  1.000 15.31605 ? 559  LYS   A C   1 
ATOM   3452 O O   . LYS   A 1 483 ? -21.54236 14.96896  -2.56373  1.000 15.67077 ? 559  LYS   A O   1 
ATOM   3453 C CB  . LYS   A 1 483 ? -23.10774 12.04578  -2.36021  1.000 13.37117 ? 559  LYS   A CB  1 
ATOM   3454 C CG  . LYS   A 1 483 ? -24.32110 11.34674  -2.97757  1.000 19.89348 ? 559  LYS   A CG  1 
ATOM   3455 C CD  . LYS   A 1 483 ? -25.08867 10.54071  -1.91301  1.000 24.29240 ? 559  LYS   A CD  1 
ATOM   3456 C CE  . LYS   A 1 483 ? -26.28062 9.81533   -2.52082  1.000 27.29355 ? 559  LYS   A CE  1 
ATOM   3457 N NZ  . LYS   A 1 483 ? -27.14814 9.16988   -1.50111  1.000 39.39048 ? 559  LYS   A NZ  1 
ATOM   3458 N N   . GLY   A 1 484 ? -20.23856 13.22117  -1.98872  1.000 11.15383 ? 560  GLY   A N   1 
ATOM   3459 C CA  . GLY   A 1 484 ? -19.28839 13.99893  -1.22358  1.000 16.57955 ? 560  GLY   A CA  1 
ATOM   3460 C C   . GLY   A 1 484 ? -18.38613 14.90120  -2.03167  1.000 17.12308 ? 560  GLY   A C   1 
ATOM   3461 O O   . GLY   A 1 484 ? -17.50070 15.54591  -1.46495  1.000 15.55496 ? 560  GLY   A O   1 
ATOM   3462 N N   . MET   A 1 485 ? -18.58260 15.00186  -3.33791  1.000 21.74086 ? 561  MET   A N   1 
ATOM   3463 C CA  . MET   A 1 485 ? -17.78558 15.98119  -4.06120  1.000 28.76440 ? 561  MET   A CA  1 
ATOM   3464 C C   . MET   A 1 485 ? -18.52817 16.54552  -5.25798  1.000 27.60525 ? 561  MET   A C   1 
ATOM   3465 O O   . MET   A 1 485 ? -17.90270 17.03825  -6.20106  1.000 27.25684 ? 561  MET   A O   1 
ATOM   3466 C CB  . MET   A 1 485 ? -16.45386 15.36351  -4.44983  1.000 34.29232 ? 561  MET   A CB  1 
ATOM   3467 C CG  . MET   A 1 485 ? -16.49859 14.26824  -5.48251  1.000 19.28996 ? 561  MET   A CG  1 
ATOM   3468 S SD  . MET   A 1 485 ? -14.92526 14.37509  -6.31545  1.000 29.48102 ? 561  MET   A SD  1 
ATOM   3469 C CE  . MET   A 1 485 ? -14.88734 12.79461  -7.15375  1.000 17.94500 ? 561  MET   A CE  1 
ATOM   3470 N N   . LYS   A 1 486 ? -19.86217 16.50782  -5.21581  1.000 26.14927 ? 562  LYS   A N   1 
ATOM   3471 C CA  . LYS   A 1 486 ? -20.66453 17.08362  -6.28904  1.000 23.34830 ? 562  LYS   A CA  1 
ATOM   3472 C C   . LYS   A 1 486 ? -20.28942 18.53775  -6.54040  1.000 26.83482 ? 562  LYS   A C   1 
ATOM   3473 O O   . LYS   A 1 486 ? -20.05438 18.94063  -7.68641  1.000 21.57426 ? 562  LYS   A O   1 
ATOM   3474 C CB  . LYS   A 1 486 ? -22.15253 16.96026  -5.95433  1.000 30.77090 ? 562  LYS   A CB  1 
ATOM   3475 C CG  . LYS   A 1 486 ? -23.06707 17.62730  -6.98138  1.000 35.82429 ? 562  LYS   A CG  1 
ATOM   3476 C CD  . LYS   A 1 486 ? -24.25455 16.75163  -7.36507  1.000 30.68437 ? 562  LYS   A CD  1 
ATOM   3477 C CE  . LYS   A 1 486 ? -25.16532 16.50534  -6.17990  1.000 36.79958 ? 562  LYS   A CE  1 
ATOM   3478 N NZ  . LYS   A 1 486 ? -26.61320 16.70601  -6.49286  1.000 33.95265 ? 562  LYS   A NZ  1 
ATOM   3479 N N   . GLU   A 1 487 ? -20.20983 19.34225  -5.47695  1.000 24.12745 ? 563  GLU   A N   1 
ATOM   3480 C CA  . GLU   A 1 487 ? -19.93346 20.76162  -5.68405  1.000 29.89834 ? 563  GLU   A CA  1 
ATOM   3481 C C   . GLU   A 1 487 ? -18.54681 20.99180  -6.26895  1.000 26.73511 ? 563  GLU   A C   1 
ATOM   3482 O O   . GLU   A 1 487 ? -18.36441 21.91958  -7.06297  1.000 26.97645 ? 563  GLU   A O   1 
ATOM   3483 C CB  . GLU   A 1 487 ? -20.10148 21.55245  -4.38678  1.000 36.95908 ? 563  GLU   A CB  1 
ATOM   3484 C CG  . GLU   A 1 487 ? -19.45457 20.94266  -3.16389  1.000 44.60168 ? 563  GLU   A CG  1 
ATOM   3485 C CD  . GLU   A 1 487 ? -20.40733 20.03304  -2.40538  1.000 58.79771 ? 563  GLU   A CD  1 
ATOM   3486 O OE1 . GLU   A 1 487 ? -21.13681 20.55076  -1.52588  1.000 55.97618 ? 563  GLU   A OE1 1 
ATOM   3487 O OE2 . GLU   A 1 487 ? -20.43440 18.81107  -2.69621  1.000 44.12316 ? 563  GLU   A OE2 1 
ATOM   3488 N N   . LEU   A 1 488 ? -17.56798 20.16066  -5.90608  1.000 18.35829 ? 564  LEU   A N   1 
ATOM   3489 C CA  . LEU   A 1 488 ? -16.23385 20.28116  -6.48875  1.000 18.95952 ? 564  LEU   A CA  1 
ATOM   3490 C C   . LEU   A 1 488 ? -16.24568 20.00812  -7.98892  1.000 26.96957 ? 564  LEU   A C   1 
ATOM   3491 O O   . LEU   A 1 488 ? -15.41905 20.55419  -8.72727  1.000 20.22473 ? 564  LEU   A O   1 
ATOM   3492 C CB  . LEU   A 1 488 ? -15.27580 19.31436  -5.79088  1.000 21.09182 ? 564  LEU   A CB  1 
ATOM   3493 C CG  . LEU   A 1 488 ? -15.00602 19.58116  -4.30825  1.000 27.70613 ? 564  LEU   A CG  1 
ATOM   3494 C CD1 . LEU   A 1 488 ? -14.01976 18.56700  -3.75902  1.000 21.34398 ? 564  LEU   A CD1 1 
ATOM   3495 C CD2 . LEU   A 1 488 ? -14.46813 20.99838  -4.13626  1.000 29.51968 ? 564  LEU   A CD2 1 
ATOM   3496 N N   . LEU   A 1 489 ? -17.17158 19.16947  -8.45581  1.000 19.14409 ? 565  LEU   A N   1 
ATOM   3497 C CA  . LEU   A 1 489 ? -17.18208 18.75511  -9.85606  1.000 21.75348 ? 565  LEU   A CA  1 
ATOM   3498 C C   . LEU   A 1 489 ? -17.73719 19.82557  -10.77688 1.000 22.80745 ? 565  LEU   A C   1 
ATOM   3499 O O   . LEU   A 1 489 ? -17.41058 19.83581  -11.97024 1.000 26.25053 ? 565  LEU   A O   1 
ATOM   3500 C CB  . LEU   A 1 489 ? -18.00784 17.47780  -10.02074 1.000 16.14222 ? 565  LEU   A CB  1 
ATOM   3501 C CG  . LEU   A 1 489 ? -17.53163 16.30408  -9.18249  1.000 20.47764 ? 565  LEU   A CG  1 
ATOM   3502 C CD1 . LEU   A 1 489 ? -18.56740 15.20169  -9.23619  1.000 19.16773 ? 565  LEU   A CD1 1 
ATOM   3503 C CD2 . LEU   A 1 489 ? -16.18685 15.80610  -9.68369  1.000 18.46591 ? 565  LEU   A CD2 1 
ATOM   3504 N N   . VAL   A 1 490 ? -18.58310 20.71340  -10.25983 1.000 18.69250 ? 566  VAL   A N   1 
ATOM   3505 C CA  . VAL   A 1 490 ? -19.23317 21.72457  -11.07938 1.000 18.29609 ? 566  VAL   A CA  1 
ATOM   3506 C C   . VAL   A 1 490 ? -18.69597 23.11851  -10.79556 1.000 30.90171 ? 566  VAL   A C   1 
ATOM   3507 O O   . VAL   A 1 490 ? -19.22058 24.09952  -11.33278 1.000 34.35394 ? 566  VAL   A O   1 
ATOM   3508 C CB  . VAL   A 1 490 ? -20.76272 21.67909  -10.90738 1.000 21.33732 ? 566  VAL   A CB  1 
ATOM   3509 C CG1 . VAL   A 1 490 ? -21.28906 20.30557  -11.31615 1.000 18.68687 ? 566  VAL   A CG1 1 
ATOM   3510 C CG2 . VAL   A 1 490 ? -21.15447 22.01084  -9.47668  1.000 21.46336 ? 566  VAL   A CG2 1 
ATOM   3511 N N   . ALA   A 1 491 ? -17.66581 23.23756  -9.96523  1.000 25.71034 ? 567  ALA   A N   1 
ATOM   3512 C CA  . ALA   A 1 491 ? -17.13980 24.55332  -9.64235  1.000 30.58885 ? 567  ALA   A CA  1 
ATOM   3513 C C   . ALA   A 1 491 ? -16.36846 25.12095  -10.82536 1.000 27.53672 ? 567  ALA   A C   1 
ATOM   3514 O O   . ALA   A 1 491 ? -15.76127 24.38509  -11.60962 1.000 32.91219 ? 567  ALA   A O   1 
ATOM   3515 C CB  . ALA   A 1 491 ? -16.23967 24.48783  -8.41022  1.000 32.15690 ? 567  ALA   A CB  1 
ATOM   3516 N N   . THR   A 1 492 ? -16.40835 26.45183  -10.94535 1.000 35.36023 ? 568  THR   A N   1 
ATOM   3517 C CA  . THR   A 1 492 ? -15.67502 27.15086  -11.99892 1.000 39.27335 ? 568  THR   A CA  1 
ATOM   3518 C C   . THR   A 1 492 ? -14.20847 26.74641  -12.00704 1.000 27.54763 ? 568  THR   A C   1 
ATOM   3519 O O   . THR   A 1 492 ? -13.65206 26.38962  -13.05252 1.000 35.29753 ? 568  THR   A O   1 
ATOM   3520 C CB  . THR   A 1 492 ? -15.81357 28.66362  -11.80245 1.000 36.70450 ? 568  THR   A CB  1 
ATOM   3521 O OG1 . THR   A 1 492 ? -17.17478 28.97806  -11.48268 1.000 46.68289 ? 568  THR   A OG1 1 
ATOM   3522 C CG2 . THR   A 1 492 ? -15.39043 29.42074  -13.04923 1.000 30.00772 ? 568  THR   A CG2 1 
ATOM   3523 N N   . LYS   A 1 493 ? -13.56900 26.80325  -10.84101 1.000 28.34574 ? 569  LYS   A N   1 
ATOM   3524 C CA  . LYS   A 1 493 ? -12.21189 26.30787  -10.65114 1.000 28.53564 ? 569  LYS   A CA  1 
ATOM   3525 C C   . LYS   A 1 493 ? -12.27356 24.86291  -10.17685 1.000 38.48808 ? 569  LYS   A C   1 
ATOM   3526 O O   . LYS   A 1 493 ? -12.99326 24.54850  -9.22294  1.000 32.61917 ? 569  LYS   A O   1 
ATOM   3527 C CB  . LYS   A 1 493 ? -11.46515 27.15772  -9.62055  1.000 31.06749 ? 569  LYS   A CB  1 
ATOM   3528 C CG  . LYS   A 1 493 ? -11.07145 28.55685  -10.08267 1.000 30.06417 ? 569  LYS   A CG  1 
ATOM   3529 C CD  . LYS   A 1 493 ? -10.71953 28.59559  -11.55826 1.000 42.09570 ? 569  LYS   A CD  1 
ATOM   3530 C CE  . LYS   A 1 493 ? -10.30266 29.99743  -11.97258 1.000 42.69439 ? 569  LYS   A CE  1 
ATOM   3531 N NZ  . LYS   A 1 493 ? -9.04236  29.99591  -12.78351 1.000 40.77042 ? 569  LYS   A NZ  1 
ATOM   3532 N N   . ILE   A 1 494 ? -11.51592 23.99004  -10.83109 1.000 24.08253 ? 570  ILE   A N   1 
ATOM   3533 C CA  . ILE   A 1 494 ? -11.46816 22.58293  -10.45697 1.000 21.08743 ? 570  ILE   A CA  1 
ATOM   3534 C C   . ILE   A 1 494 ? -10.36991 22.41308  -9.41237  1.000 26.48849 ? 570  ILE   A C   1 
ATOM   3535 O O   . ILE   A 1 494 ? -9.18446  22.60595  -9.70081  1.000 30.31752 ? 570  ILE   A O   1 
ATOM   3536 C CB  . ILE   A 1 494 ? -11.23584 21.68739  -11.67906 1.000 19.24579 ? 570  ILE   A CB  1 
ATOM   3537 C CG1 . ILE   A 1 494 ? -12.50397 21.65200  -12.54117 1.000 21.43149 ? 570  ILE   A CG1 1 
ATOM   3538 C CG2 . ILE   A 1 494 ? -10.82635 20.28696  -11.24539 1.000 21.50656 ? 570  ILE   A CG2 1 
ATOM   3539 C CD1 . ILE   A 1 494 ? -12.26829 21.17167  -13.94028 1.000 18.88411 ? 570  ILE   A CD1 1 
ATOM   3540 N N   . ASN   A 1 495 ? -10.76581 22.06322  -8.19100  1.000 17.50687 ? 571  ASN   A N   1 
ATOM   3541 C CA  . ASN   A 1 495 ? -9.82690  21.90439  -7.08233  1.000 22.13640 ? 571  ASN   A CA  1 
ATOM   3542 C C   . ASN   A 1 495 ? -9.22679  20.50577  -7.16681  1.000 21.63277 ? 571  ASN   A C   1 
ATOM   3543 O O   . ASN   A 1 495 ? -9.76659  19.53231  -6.63260  1.000 19.63143 ? 571  ASN   A O   1 
ATOM   3544 C CB  . ASN   A 1 495 ? -10.52207 22.15536  -5.74745  1.000 20.81669 ? 571  ASN   A CB  1 
ATOM   3545 C CG  . ASN   A 1 495 ? -9.55203  22.20935  -4.58566  1.000 21.01800 ? 571  ASN   A CG  1 
ATOM   3546 O OD1 . ASN   A 1 495 ? -8.48366  21.60122  -4.62646  1.000 21.51126 ? 571  ASN   A OD1 1 
ATOM   3547 N ND2 . ASN   A 1 495 ? -9.92706  22.92933  -3.53197  1.000 21.08575 ? 571  ASN   A ND2 1 
ATOM   3548 N N   . SER   A 1 496 ? -8.07138  20.42422  -7.83247  1.000 27.12325 ? 572  SER   A N   1 
ATOM   3549 C CA  . SER   A 1 496 ? -7.45093  19.13593  -8.12235  1.000 22.25494 ? 572  SER   A CA  1 
ATOM   3550 C C   . SER   A 1 496 ? -7.12437  18.37046  -6.84711  1.000 26.06623 ? 572  SER   A C   1 
ATOM   3551 O O   . SER   A 1 496 ? -7.45660  17.18777  -6.72564  1.000 21.19931 ? 572  SER   A O   1 
ATOM   3552 C CB  . SER   A 1 496 ? -6.19089  19.34038  -8.96565  1.000 22.38830 ? 572  SER   A CB  1 
ATOM   3553 O OG  . SER   A 1 496 ? -5.46527  18.12714  -9.09453  1.000 33.18261 ? 572  SER   A OG  1 
ATOM   3554 N N   . SER   A 1 497 ? -6.48163  19.02887  -5.87705  1.000 21.66185 ? 573  SER   A N   1 
ATOM   3555 C CA  . SER   A 1 497 ? -6.04671  18.31481  -4.68014  1.000 22.59349 ? 573  SER   A CA  1 
ATOM   3556 C C   . SER   A 1 497 ? -7.23431  17.79061  -3.88451  1.000 20.42986 ? 573  SER   A C   1 
ATOM   3557 O O   . SER   A 1 497 ? -7.18484  16.67462  -3.35529  1.000 19.70826 ? 573  SER   A O   1 
ATOM   3558 C CB  . SER   A 1 497 ? -5.17231  19.21423  -3.80243  1.000 26.71471 ? 573  SER   A CB  1 
ATOM   3559 O OG  . SER   A 1 497 ? -5.86454  20.38763  -3.42222  1.000 36.28105 ? 573  SER   A OG  1 
ATOM   3560 N N   . ALA   A 1 498 ? -8.30770  18.58189  -3.78495  1.000 18.34554 ? 574  ALA   A N   1 
ATOM   3561 C CA  . ALA   A 1 498 ? -9.49145  18.13756  -3.05465  1.000 17.74592 ? 574  ALA   A CA  1 
ATOM   3562 C C   . ALA   A 1 498 ? -10.18114 16.97563  -3.76182  1.000 17.54808 ? 574  ALA   A C   1 
ATOM   3563 O O   . ALA   A 1 498 ? -10.63417 16.02479  -3.11188  1.000 15.43420 ? 574  ALA   A O   1 
ATOM   3564 C CB  . ALA   A 1 498 ? -10.46364 19.30031  -2.87076  1.000 17.72026 ? 574  ALA   A CB  1 
ATOM   3565 N N   . ILE   A 1 499 ? -10.28685 17.03721  -5.09040  1.000 16.50426 ? 575  ILE   A N   1 
ATOM   3566 C CA  . ILE   A 1 499 ? -10.88969 15.92863  -5.82776  1.000 17.88820 ? 575  ILE   A CA  1 
ATOM   3567 C C   . ILE   A 1 499 ? -10.05709 14.66375  -5.66085  1.000 17.48562 ? 575  ILE   A C   1 
ATOM   3568 O O   . ILE   A 1 499 ? -10.60030 13.55819  -5.54583  1.000 16.99737 ? 575  ILE   A O   1 
ATOM   3569 C CB  . ILE   A 1 499 ? -11.07668 16.30997  -7.30910  1.000 19.29724 ? 575  ILE   A CB  1 
ATOM   3570 C CG1 . ILE   A 1 499 ? -12.26543 17.26259  -7.44814  1.000 21.16366 ? 575  ILE   A CG1 1 
ATOM   3571 C CG2 . ILE   A 1 499 ? -11.31146 15.06848  -8.16534  1.000 16.92605 ? 575  ILE   A CG2 1 
ATOM   3572 C CD1 . ILE   A 1 499 ? -12.27610 18.05892  -8.74644  1.000 27.73094 ? 575  ILE   A CD1 1 
ATOM   3573 N N   . LYS   A 1 500 ? -8.72590  14.80449  -5.62328  1.000 21.89166 ? 576  LYS   A N   1 
ATOM   3574 C CA  . LYS   A 1 500 ? -7.86366  13.64636  -5.39876  1.000 16.67778 ? 576  LYS   A CA  1 
ATOM   3575 C C   . LYS   A 1 500 ? -8.08145  13.05604  -4.01541  1.000 16.79388 ? 576  LYS   A C   1 
ATOM   3576 O O   . LYS   A 1 500 ? -8.18591  11.83377  -3.85990  1.000 17.17767 ? 576  LYS   A O   1 
ATOM   3577 C CB  . LYS   A 1 500 ? -6.39189  14.02797  -5.57667  1.000 22.18990 ? 576  LYS   A CB  1 
ATOM   3578 C CG  . LYS   A 1 500 ? -6.02306  14.43161  -6.98985  1.000 32.08948 ? 576  LYS   A CG  1 
ATOM   3579 C CD  . LYS   A 1 500 ? -4.60182  13.99956  -7.31241  1.000 36.75500 ? 576  LYS   A CD  1 
ATOM   3580 C CE  . LYS   A 1 500 ? -3.62448  14.64790  -6.35358  1.000 43.35656 ? 576  LYS   A CE  1 
ATOM   3581 N NZ  . LYS   A 1 500 ? -2.32541  14.96499  -6.99980  1.000 35.95998 ? 576  LYS   A NZ  1 
ATOM   3582 N N   . LEU   A 1 501 ? -8.11108  13.91098  -2.98838  1.000 16.81261 ? 577  LEU   A N   1 
ATOM   3583 C CA  . LEU   A 1 501 ? -8.44868  13.45205  -1.64565  1.000 16.68278 ? 577  LEU   A CA  1 
ATOM   3584 C C   . LEU   A 1 501 ? -9.78553  12.72339  -1.63033  1.000 16.13752 ? 577  LEU   A C   1 
ATOM   3585 O O   . LEU   A 1 501 ? -9.91851  11.66178  -1.01350  1.000 15.48395 ? 577  LEU   A O   1 
ATOM   3586 C CB  . LEU   A 1 501 ? -8.48948  14.64345  -0.68836  1.000 18.27763 ? 577  LEU   A CB  1 
ATOM   3587 C CG  . LEU   A 1 501 ? -8.13627  14.49359  0.78662   1.000 35.52161 ? 577  LEU   A CG  1 
ATOM   3588 C CD1 . LEU   A 1 501 ? -6.71249  13.99137  0.96806   1.000 21.36096 ? 577  LEU   A CD1 1 
ATOM   3589 C CD2 . LEU   A 1 501 ? -8.32931  15.84115  1.47576   1.000 35.54283 ? 577  LEU   A CD2 1 
ATOM   3590 N N   . GLN   A 1 502 ? -10.79365 13.28158  -2.30286  1.000 15.64590 ? 578  GLN   A N   1 
ATOM   3591 C CA  . GLN   A 1 502 ? -12.12126 12.68943  -2.22800  1.000 13.29175 ? 578  GLN   A CA  1 
ATOM   3592 C C   . GLN   A 1 502 ? -12.19684 11.39397  -3.01751  1.000 14.19430 ? 578  GLN   A C   1 
ATOM   3593 O O   . GLN   A 1 502 ? -12.78220 10.40840  -2.54858  1.000 12.03991 ? 578  GLN   A O   1 
ATOM   3594 C CB  . GLN   A 1 502 ? -13.17833 13.67693  -2.72749  1.000 13.21956 ? 578  GLN   A CB  1 
ATOM   3595 C CG  . GLN   A 1 502 ? -14.56593 13.06534  -2.73424  1.000 13.59875 ? 578  GLN   A CG  1 
ATOM   3596 C CD  . GLN   A 1 502 ? -15.11643 12.84216  -1.33245  1.000 12.62155 ? 578  GLN   A CD  1 
ATOM   3597 O OE1 . GLN   A 1 502 ? -14.54188 13.29771  -0.33836  1.000 14.82394 ? 578  GLN   A OE1 1 
ATOM   3598 N NE2 . GLN   A 1 502 ? -16.23173 12.13485  -1.24870  1.000 10.54578 ? 578  GLN   A NE2 1 
ATOM   3599 N N   . LEU   A 1 503 ? -11.61500 11.36498  -4.22233  1.000 13.99905 ? 579  LEU   A N   1 
ATOM   3600 C CA  . LEU   A 1 503 ? -11.69449 10.13811  -5.00751  1.000 15.44657 ? 579  LEU   A CA  1 
ATOM   3601 C C   . LEU   A 1 503 ? -10.93310 8.98912   -4.34810  1.000 14.14239 ? 579  LEU   A C   1 
ATOM   3602 O O   . LEU   A 1 503 ? -11.32959 7.82223   -4.49281  1.000 15.79701 ? 579  LEU   A O   1 
ATOM   3603 C CB  . LEU   A 1 503 ? -11.18189 10.37633  -6.42836  1.000 17.87899 ? 579  LEU   A CB  1 
ATOM   3604 C CG  . LEU   A 1 503 ? -11.59506 9.28388   -7.42573  1.000 16.61331 ? 579  LEU   A CG  1 
ATOM   3605 C CD1 . LEU   A 1 503 ? -13.09731 9.27605   -7.64990  1.000 11.48056 ? 579  LEU   A CD1 1 
ATOM   3606 C CD2 . LEU   A 1 503 ? -10.84593 9.42593   -8.73271  1.000 17.69095 ? 579  LEU   A CD2 1 
ATOM   3607 N N   . THR   A 1 504 ? -9.86920  9.29234   -3.60356  1.000 15.29420 ? 580  THR   A N   1 
ATOM   3608 C CA  . THR   A 1 504 ? -9.05923  8.27733   -2.93280  1.000 18.60231 ? 580  THR   A CA  1 
ATOM   3609 C C   . THR   A 1 504 ? -9.50843  7.97661   -1.50987  1.000 18.15614 ? 580  THR   A C   1 
ATOM   3610 O O   . THR   A 1 504 ? -8.83484  7.19702   -0.82413  1.000 16.92267 ? 580  THR   A O   1 
ATOM   3611 C CB  . THR   A 1 504 ? -7.58152  8.69897   -2.88764  1.000 17.46619 ? 580  THR   A CB  1 
ATOM   3612 O OG1 . THR   A 1 504 ? -7.45551  9.93026   -2.16936  1.000 25.29616 ? 580  THR   A OG1 1 
ATOM   3613 C CG2 . THR   A 1 504 ? -7.03118  8.88114   -4.28429  1.000 21.56177 ? 580  THR   A CG2 1 
ATOM   3614 N N   . ALA   A 1 505 ? -10.60159 8.57620   -1.03842  1.000 16.86684 ? 581  ALA   A N   1 
ATOM   3615 C CA  . ALA   A 1 505 ? -11.05031 8.31849   0.32540   1.000 17.96974 ? 581  ALA   A CA  1 
ATOM   3616 C C   . ALA   A 1 505 ? -11.36096 6.84027   0.50136   1.000 20.12287 ? 581  ALA   A C   1 
ATOM   3617 O O   . ALA   A 1 505 ? -11.95280 6.20051   -0.37372  1.000 16.17829 ? 581  ALA   A O   1 
ATOM   3618 C CB  . ALA   A 1 505 ? -12.28007 9.15983   0.66867   1.000 12.30087 ? 581  ALA   A CB  1 
ATOM   3619 N N   . GLN   A 1 506 ? -10.94045 6.29499   1.63751   1.000 23.29026 ? 582  GLN   A N   1 
ATOM   3620 C CA  . GLN   A 1 506 ? -10.99802 4.85552   1.83189   1.000 25.83632 ? 582  GLN   A CA  1 
ATOM   3621 C C   . GLN   A 1 506 ? -12.44392 4.39722   1.89832   1.000 29.77861 ? 582  GLN   A C   1 
ATOM   3622 O O   . GLN   A 1 506 ? -13.27758 5.00900   2.57684   1.000 25.32667 ? 582  GLN   A O   1 
ATOM   3623 C CB  . GLN   A 1 506 ? -10.25258 4.45505   3.10503   1.000 30.98908 ? 582  GLN   A CB  1 
ATOM   3624 C CG  . GLN   A 1 506 ? -8.89936  3.81544   2.85255   1.000 46.74740 ? 582  GLN   A CG  1 
ATOM   3625 C CD  . GLN   A 1 506 ? -7.93013  4.02716   4.00732   1.000 50.49170 ? 582  GLN   A CD  1 
ATOM   3626 O OE1 . GLN   A 1 506 ? -8.24012  3.71097   5.15863   1.000 45.70490 ? 582  GLN   A OE1 1 
ATOM   3627 N NE2 . GLN   A 1 506 ? -6.75455  4.57620   3.70526   1.000 42.44293 ? 582  GLN   A NE2 1 
ATOM   3628 N N   . SER   A 1 507 ? -12.74243 3.33609   1.16101   1.000 28.67000 ? 583  SER   A N   1 
ATOM   3629 C CA  . SER   A 1 507 ? -14.02792 2.67488   1.24453   1.000 33.24832 ? 583  SER   A CA  1 
ATOM   3630 C C   . SER   A 1 507 ? -13.98956 1.69799   2.41517   1.000 42.59826 ? 583  SER   A C   1 
ATOM   3631 O O   . SER   A 1 507 ? -15.00540 1.09438   2.76290   1.000 35.46968 ? 583  SER   A O   1 
ATOM   3632 C CB  . SER   A 1 507 ? -14.34645 1.94189   -0.05978  1.000 31.16604 ? 583  SER   A CB  1 
ATOM   3633 O OG  . SER   A 1 507 ? -13.16799 1.34509   -0.58691  1.000 32.17731 ? 583  SER   A OG  1 
ATOM   3634 O OXT . SER   A 1 507 ? -12.92998 1.50009   3.02925   1.000 28.15947 ? 583  SER   A OXT 1 
ATOM   3635 N N   . LEU   B 1 21  ? 10.80280  46.08248  -34.61997 1.000 41.28894 ? 3    LEU   B N   1 
ATOM   3636 C CA  . LEU   B 1 21  ? 11.66479  45.09656  -35.26897 1.000 36.30327 ? 3    LEU   B CA  1 
ATOM   3637 C C   . LEU   B 1 21  ? 12.77248  45.80908  -36.03982 1.000 36.45347 ? 3    LEU   B C   1 
ATOM   3638 O O   . LEU   B 1 21  ? 12.52263  46.82527  -36.68813 1.000 43.28711 ? 3    LEU   B O   1 
ATOM   3639 C CB  . LEU   B 1 21  ? 10.84917  44.19923  -36.20970 1.000 26.07923 ? 3    LEU   B CB  1 
ATOM   3640 C CG  . LEU   B 1 21  ? 9.80577   43.28281  -35.56694 1.000 31.68766 ? 3    LEU   B CG  1 
ATOM   3641 C CD1 . LEU   B 1 21  ? 9.08043   42.45918  -36.61493 1.000 26.60174 ? 3    LEU   B CD1 1 
ATOM   3642 C CD2 . LEU   B 1 21  ? 10.45366  42.37705  -34.52058 1.000 29.85695 ? 3    LEU   B CD2 1 
ATOM   3643 N N   . LYS   B 1 22  ? 13.99323  45.28557  -35.98337 1.000 35.91291 ? 4    LYS   B N   1 
ATOM   3644 C CA  . LYS   B 1 22  ? 15.08112  45.91558  -36.71643 1.000 37.31158 ? 4    LYS   B CA  1 
ATOM   3645 C C   . LYS   B 1 22  ? 15.11462  45.41929  -38.16102 1.000 38.90805 ? 4    LYS   B C   1 
ATOM   3646 O O   . LYS   B 1 22  ? 14.51547  44.39885  -38.51331 1.000 26.87620 ? 4    LYS   B O   1 
ATOM   3647 C CB  . LYS   B 1 22  ? 16.42787  45.66359  -36.03823 1.000 46.14467 ? 4    LYS   B CB  1 
ATOM   3648 C CG  . LYS   B 1 22  ? 16.71106  44.22989  -35.64827 1.000 45.18869 ? 4    LYS   B CG  1 
ATOM   3649 C CD  . LYS   B 1 22  ? 18.12828  44.13522  -35.10874 1.000 49.95373 ? 4    LYS   B CD  1 
ATOM   3650 C CE  . LYS   B 1 22  ? 18.51122  42.71989  -34.73455 1.000 55.26212 ? 4    LYS   B CE  1 
ATOM   3651 N NZ  . LYS   B 1 22  ? 19.73726  42.34085  -35.50080 1.000 56.85615 ? 4    LYS   B NZ  1 
ATOM   3652 N N   . THR   B 1 23  ? 15.82802  46.17033  -39.00464 1.000 36.06771 ? 5    THR   B N   1 
ATOM   3653 C CA  . THR   B 1 23  ? 15.77700  45.91134  -40.44030 1.000 39.12144 ? 5    THR   B CA  1 
ATOM   3654 C C   . THR   B 1 23  ? 16.39119  44.56153  -40.80220 1.000 39.97106 ? 5    THR   B C   1 
ATOM   3655 O O   . THR   B 1 23  ? 15.96645  43.93380  -41.78180 1.000 40.69511 ? 5    THR   B O   1 
ATOM   3656 C CB  . THR   B 1 23  ? 16.46244  47.05103  -41.20425 1.000 37.69951 ? 5    THR   B CB  1 
ATOM   3657 O OG1 . THR   B 1 23  ? 17.86257  46.77790  -41.33491 1.000 56.71747 ? 5    THR   B OG1 1 
ATOM   3658 C CG2 . THR   B 1 23  ? 16.27395  48.36698  -40.47365 1.000 30.98675 ? 5    THR   B CG2 1 
ATOM   3659 N N   . ALA   B 1 24  ? 17.38123  44.09745  -40.03381 1.000 38.95524 ? 6    ALA   B N   1 
ATOM   3660 C CA  . ALA   B 1 24  ? 17.94156  42.77095  -40.27836 1.000 34.74583 ? 6    ALA   B CA  1 
ATOM   3661 C C   . ALA   B 1 24  ? 16.87611  41.69146  -40.13550 1.000 35.41868 ? 6    ALA   B C   1 
ATOM   3662 O O   . ALA   B 1 24  ? 16.86479  40.71165  -40.89008 1.000 39.99819 ? 6    ALA   B O   1 
ATOM   3663 C CB  . ALA   B 1 24  ? 19.10251  42.50383  -39.32147 1.000 40.33858 ? 6    ALA   B CB  1 
ATOM   3664 N N   . GLN   B 1 25  ? 15.96633  41.85958  -39.17586 1.000 35.71680 ? 7    GLN   B N   1 
ATOM   3665 C CA  . GLN   B 1 25  ? 14.89356  40.88811  -38.99267 1.000 39.59117 ? 7    GLN   B CA  1 
ATOM   3666 C C   . GLN   B 1 25  ? 13.84266  41.02113  -40.08928 1.000 37.89538 ? 7    GLN   B C   1 
ATOM   3667 O O   . GLN   B 1 25  ? 13.41717  40.01995  -40.67839 1.000 34.66285 ? 7    GLN   B O   1 
ATOM   3668 C CB  . GLN   B 1 25  ? 14.26595  41.06168  -37.60813 1.000 38.57984 ? 7    GLN   B CB  1 
ATOM   3669 C CG  . GLN   B 1 25  ? 15.26853  40.94575  -36.46496 1.000 36.19173 ? 7    GLN   B CG  1 
ATOM   3670 C CD  . GLN   B 1 25  ? 14.71356  41.41972  -35.13453 1.000 34.52631 ? 7    GLN   B CD  1 
ATOM   3671 O OE1 . GLN   B 1 25  ? 13.90186  42.34392  -35.07716 1.000 39.71020 ? 7    GLN   B OE1 1 
ATOM   3672 N NE2 . GLN   B 1 25  ? 15.16112  40.79295  -34.05119 1.000 37.33502 ? 7    GLN   B NE2 1 
ATOM   3673 N N   . LYS   B 1 26  ? 13.42978  42.25764  -40.39312 1.000 31.65377 ? 8    LYS   B N   1 
ATOM   3674 C CA  . LYS   B 1 26  ? 12.37083  42.47499  -41.37935 1.000 37.55838 ? 8    LYS   B CA  1 
ATOM   3675 C C   . LYS   B 1 26  ? 12.73059  41.90994  -42.74886 1.000 33.36989 ? 8    LYS   B C   1 
ATOM   3676 O O   . LYS   B 1 26  ? 11.84181  41.48934  -43.49686 1.000 33.24014 ? 8    LYS   B O   1 
ATOM   3677 C CB  . LYS   B 1 26  ? 12.05379  43.96883  -41.50680 1.000 38.00593 ? 8    LYS   B CB  1 
ATOM   3678 C CG  . LYS   B 1 26  ? 11.31208  44.57297  -40.32419 1.000 35.88228 ? 8    LYS   B CG  1 
ATOM   3679 C CD  . LYS   B 1 26  ? 11.88013  45.92647  -39.93741 1.000 41.78574 ? 8    LYS   B CD  1 
ATOM   3680 C CE  . LYS   B 1 26  ? 10.76117  46.91628  -39.68151 1.000 41.53046 ? 8    LYS   B CE  1 
ATOM   3681 N NZ  . LYS   B 1 26  ? 11.26460  48.28070  -39.37407 1.000 40.18959 ? 8    LYS   B NZ  1 
ATOM   3682 N N   . THR   B 1 27  ? 14.02014  41.88463  -43.09074 1.000 35.82078 ? 9    THR   B N   1 
ATOM   3683 C CA  . THR   B 1 27  ? 14.43804  41.47712  -44.42981 1.000 36.29411 ? 9    THR   B CA  1 
ATOM   3684 C C   . THR   B 1 27  ? 14.09615  40.01961  -44.71505 1.000 32.27892 ? 9    THR   B C   1 
ATOM   3685 O O   . THR   B 1 27  ? 13.88957  39.64419  -45.87551 1.000 30.26916 ? 9    THR   B O   1 
ATOM   3686 C CB  . THR   B 1 27  ? 15.94112  41.73815  -44.58828 1.000 38.92792 ? 9    THR   B CB  1 
ATOM   3687 O OG1 . THR   B 1 27  ? 16.15941  43.15047  -44.65779 1.000 40.61050 ? 9    THR   B OG1 1 
ATOM   3688 C CG2 . THR   B 1 27  ? 16.50746  41.08876  -45.84255 1.000 38.90236 ? 9    THR   B CG2 1 
ATOM   3689 N N   . LEU   B 1 28  ? 13.99895  39.19650  -43.67700 1.000 27.64600 ? 10   LEU   B N   1 
ATOM   3690 C CA  . LEU   B 1 28  ? 13.70426  37.78044  -43.83414 1.000 27.09239 ? 10   LEU   B CA  1 
ATOM   3691 C C   . LEU   B 1 28  ? 12.22174  37.48636  -44.03650 1.000 30.85997 ? 10   LEU   B C   1 
ATOM   3692 O O   . LEU   B 1 28  ? 11.86894  36.32411  -44.26395 1.000 29.65640 ? 10   LEU   B O   1 
ATOM   3693 C CB  . LEU   B 1 28  ? 14.24137  37.01849  -42.62076 1.000 29.03668 ? 10   LEU   B CB  1 
ATOM   3694 C CG  . LEU   B 1 28  ? 15.73694  37.29337  -42.43654 1.000 32.43539 ? 10   LEU   B CG  1 
ATOM   3695 C CD1 . LEU   B 1 28  ? 16.17932  37.19431  -40.97632 1.000 40.53919 ? 10   LEU   B CD1 1 
ATOM   3696 C CD2 . LEU   B 1 28  ? 16.55084  36.35234  -43.32516 1.000 31.53740 ? 10   LEU   B CD2 1 
ATOM   3697 N N   . PHE   B 1 29  ? 11.33819  38.51674  -43.99288 1.000 24.74682 ? 11   PHE   B N   1 
ATOM   3698 C CA  . PHE   B 1 29  ? 9.91301   38.31515  -44.20407 1.000 24.58041 ? 11   PHE   B CA  1 
ATOM   3699 C C   . PHE   B 1 29  ? 9.52540   38.65975  -45.63985 1.000 30.87359 ? 11   PHE   B C   1 
ATOM   3700 O O   . PHE   B 1 29  ? 10.19616  39.46298  -46.29070 1.000 24.61750 ? 11   PHE   B O   1 
ATOM   3701 C CB  . PHE   B 1 29  ? 9.09938   39.16745  -43.22146 1.000 22.00639 ? 11   PHE   B CB  1 
ATOM   3702 C CG  . PHE   B 1 29  ? 9.10182   38.62337  -41.83672 1.000 21.38050 ? 11   PHE   B CG  1 
ATOM   3703 C CD1 . PHE   B 1 29  ? 10.20108  38.80861  -41.01394 1.000 22.77047 ? 11   PHE   B CD1 1 
ATOM   3704 C CD2 . PHE   B 1 29  ? 8.02679   37.87186  -41.36906 1.000 21.11317 ? 11   PHE   B CD2 1 
ATOM   3705 C CE1 . PHE   B 1 29  ? 10.22666  38.27709  -39.73846 1.000 23.58543 ? 11   PHE   B CE1 1 
ATOM   3706 C CE2 . PHE   B 1 29  ? 8.03832   37.33912  -40.09708 1.000 17.80657 ? 11   PHE   B CE2 1 
ATOM   3707 C CZ  . PHE   B 1 29  ? 9.13780   37.53593  -39.27552 1.000 24.50185 ? 11   PHE   B CZ  1 
ATOM   3708 N N   . PRO   B 1 30  ? 8.45678   38.05286  -46.18718 1.000 19.49717 ? 12   PRO   B N   1 
ATOM   3709 C CA  . PRO   B 1 30  ? 7.57008   37.05876  -45.55980 1.000 20.65687 ? 12   PRO   B CA  1 
ATOM   3710 C C   . PRO   B 1 30  ? 8.20729   35.68209  -45.43242 1.000 22.22836 ? 12   PRO   B C   1 
ATOM   3711 O O   . PRO   B 1 30  ? 9.05237   35.28748  -46.22715 1.000 17.08821 ? 12   PRO   B O   1 
ATOM   3712 C CB  . PRO   B 1 30  ? 6.36188   37.01531  -46.50273 1.000 19.19419 ? 12   PRO   B CB  1 
ATOM   3713 C CG  . PRO   B 1 30  ? 6.86429   37.49634  -47.84196 1.000 23.77517 ? 12   PRO   B CG  1 
ATOM   3714 C CD  . PRO   B 1 30  ? 8.14317   38.26727  -47.61165 1.000 18.49009 ? 12   PRO   B CD  1 
ATOM   3715 N N   . LEU   B 1 31  ? 7.81567   34.92028  -44.42046 1.000 17.65500 ? 13   LEU   B N   1 
ATOM   3716 C CA  . LEU   B 1 31  ? 8.18868   33.51704  -44.33104 1.000 17.33190 ? 13   LEU   B CA  1 
ATOM   3717 C C   . LEU   B 1 31  ? 7.16942   32.71720  -45.12985 1.000 18.77474 ? 13   LEU   B C   1 
ATOM   3718 O O   . LEU   B 1 31  ? 5.97300   32.74779  -44.82260 1.000 14.80673 ? 13   LEU   B O   1 
ATOM   3719 C CB  . LEU   B 1 31  ? 8.23422   33.05558  -42.87375 1.000 15.17227 ? 13   LEU   B CB  1 
ATOM   3720 C CG  . LEU   B 1 31  ? 8.79846   34.09882  -41.90463 1.000 15.75457 ? 13   LEU   B CG  1 
ATOM   3721 C CD1 . LEU   B 1 31  ? 8.65034   33.62723  -40.46152 1.000 21.28895 ? 13   LEU   B CD1 1 
ATOM   3722 C CD2 . LEU   B 1 31  ? 10.26390  34.42515  -42.22320 1.000 20.15688 ? 13   LEU   B CD2 1 
ATOM   3723 N N   . ARG   B 1 32  ? 7.64039   32.02136  -46.16196 1.000 14.77236 ? 14   ARG   B N   1 
ATOM   3724 C CA  . ARG   B 1 32  ? 6.78270   31.25401  -47.05216 1.000 19.94296 ? 14   ARG   B CA  1 
ATOM   3725 C C   . ARG   B 1 32  ? 7.00712   29.75416  -46.93715 1.000 19.99106 ? 14   ARG   B C   1 
ATOM   3726 O O   . ARG   B 1 32  ? 6.35347   28.98482  -47.65006 1.000 22.32430 ? 14   ARG   B O   1 
ATOM   3727 C CB  . ARG   B 1 32  ? 7.02477   31.67478  -48.50243 1.000 19.57839 ? 14   ARG   B CB  1 
ATOM   3728 C CG  . ARG   B 1 32  ? 6.28780   32.90940  -48.96807 1.000 25.90640 ? 14   ARG   B CG  1 
ATOM   3729 C CD  . ARG   B 1 32  ? 7.15621   33.58738  -50.01503 1.000 29.93846 ? 14   ARG   B CD  1 
ATOM   3730 N NE  . ARG   B 1 32  ? 6.66038   34.88330  -50.45479 1.000 29.31876 ? 14   ARG   B NE  1 
ATOM   3731 C CZ  . ARG   B 1 32  ? 7.16902   35.55398  -51.47906 1.000 34.59016 ? 14   ARG   B CZ  1 
ATOM   3732 N NH1 . ARG   B 1 32  ? 8.23028   35.10845  -52.13771 1.000 35.55642 ? 14   ARG   B NH1 1 
ATOM   3733 N NH2 . ARG   B 1 32  ? 6.60290   36.69792  -51.84998 1.000 35.06548 ? 14   ARG   B NH2 1 
ATOM   3734 N N   . SER   B 1 33  ? 7.92367   29.31768  -46.08104 1.000 17.81585 ? 15   SER   B N   1 
ATOM   3735 C CA  . SER   B 1 33  ? 8.27484   27.90850  -46.02039 1.000 18.53611 ? 15   SER   B CA  1 
ATOM   3736 C C   . SER   B 1 33  ? 8.95057   27.61620  -44.68782 1.000 15.51257 ? 15   SER   B C   1 
ATOM   3737 O O   . SER   B 1 33  ? 9.34672   28.52325  -43.95062 1.000 17.54868 ? 15   SER   B O   1 
ATOM   3738 C CB  . SER   B 1 33  ? 9.19993   27.52438  -47.17905 1.000 20.33169 ? 15   SER   B CB  1 
ATOM   3739 O OG  . SER   B 1 33  ? 10.42596  28.22515  -47.07140 1.000 20.07013 ? 15   SER   B OG  1 
ATOM   3740 N N   . ILE   B 1 34  ? 9.10032   26.32093  -44.41097 1.000 15.41372 ? 16   ILE   B N   1 
ATOM   3741 C CA  . ILE   B 1 34  ? 9.85338   25.87140  -43.23958 1.000 17.33310 ? 16   ILE   B CA  1 
ATOM   3742 C C   . ILE   B 1 34  ? 11.27109  26.42456  -43.27716 1.000 22.82534 ? 16   ILE   B C   1 
ATOM   3743 O O   . ILE   B 1 34  ? 11.79680  26.91593  -42.26959 1.000 20.79109 ? 16   ILE   B O   1 
ATOM   3744 C CB  . ILE   B 1 34  ? 9.86350   24.33435  -43.18575 1.000 21.92300 ? 16   ILE   B CB  1 
ATOM   3745 C CG1 . ILE   B 1 34  ? 8.48708   23.80103  -42.78074 1.000 14.80592 ? 16   ILE   B CG1 1 
ATOM   3746 C CG2 . ILE   B 1 34  ? 10.97610  23.83986  -42.25736 1.000 14.54235 ? 16   ILE   B CG2 1 
ATOM   3747 C CD1 . ILE   B 1 34  ? 8.32616   22.31889  -43.03076 1.000 21.16658 ? 16   ILE   B CD1 1 
ATOM   3748 N N   . ASP   B 1 35  ? 11.91217  26.33892  -44.44659 1.000 18.80446 ? 17   ASP   B N   1 
ATOM   3749 C CA  . ASP   B 1 35  ? 13.27377  26.83958  -44.61102 1.000 23.14012 ? 17   ASP   B CA  1 
ATOM   3750 C C   . ASP   B 1 35  ? 13.36354  28.32049  -44.28179 1.000 18.53898 ? 17   ASP   B C   1 
ATOM   3751 O O   . ASP   B 1 35  ? 14.36366  28.78218  -43.72153 1.000 17.33150 ? 17   ASP   B O   1 
ATOM   3752 C CB  . ASP   B 1 35  ? 13.73561  26.59810  -46.04496 1.000 27.91403 ? 17   ASP   B CB  1 
ATOM   3753 C CG  . ASP   B 1 35  ? 14.29118  25.21680  -46.24927 1.000 41.77053 ? 17   ASP   B CG  1 
ATOM   3754 O OD1 . ASP   B 1 35  ? 14.09958  24.35327  -45.35885 1.000 36.95261 ? 17   ASP   B OD1 1 
ATOM   3755 O OD2 . ASP   B 1 35  ? 14.88566  24.99187  -47.32413 1.000 41.35293 ? 17   ASP   B OD2 1 
ATOM   3756 N N   . ASP   B 1 36  ? 12.33991  29.08895  -44.65306 1.000 21.87672 ? 18   ASP   B N   1 
ATOM   3757 C CA  . ASP   B 1 36  ? 12.31713  30.49250  -44.27603 1.000 17.19963 ? 18   ASP   B CA  1 
ATOM   3758 C C   . ASP   B 1 36  ? 12.32183  30.64575  -42.75975 1.000 18.37074 ? 18   ASP   B C   1 
ATOM   3759 O O   . ASP   B 1 36  ? 13.04674  31.48647  -42.22204 1.000 17.07305 ? 18   ASP   B O   1 
ATOM   3760 C CB  . ASP   B 1 36  ? 11.10129  31.18531  -44.89719 1.000 14.55789 ? 18   ASP   B CB  1 
ATOM   3761 C CG  . ASP   B 1 36  ? 11.28418  31.47610  -46.38845 1.000 21.09637 ? 18   ASP   B CG  1 
ATOM   3762 O OD1 . ASP   B 1 36  ? 12.41377  31.30856  -46.90670 1.000 25.06082 ? 18   ASP   B OD1 1 
ATOM   3763 O OD2 . ASP   B 1 36  ? 10.29240  31.86838  -47.04346 1.000 19.00640 ? 18   ASP   B OD2 1 
ATOM   3764 N N   . VAL   B 1 37  ? 11.53221  29.83068  -42.05170 1.000 15.84512 ? 19   VAL   B N   1 
ATOM   3765 C CA  . VAL   B 1 37  ? 11.52643  29.89233  -40.59036 1.000 15.96277 ? 19   VAL   B CA  1 
ATOM   3766 C C   . VAL   B 1 37  ? 12.90305  29.54994  -40.03702 1.000 16.20279 ? 19   VAL   B C   1 
ATOM   3767 O O   . VAL   B 1 37  ? 13.42161  30.22832  -39.13893 1.000 16.15512 ? 19   VAL   B O   1 
ATOM   3768 C CB  . VAL   B 1 37  ? 10.44927  28.95882  -40.01142 1.000 11.43895 ? 19   VAL   B CB  1 
ATOM   3769 C CG1 . VAL   B 1 37  ? 10.47768  29.04308  -38.48043 1.000 15.12758 ? 19   VAL   B CG1 1 
ATOM   3770 C CG2 . VAL   B 1 37  ? 9.07393   29.33771  -40.55768 1.000 14.11315 ? 19   VAL   B CG2 1 
ATOM   3771 N N   . VAL   B 1 38  ? 13.51390  28.48944  -40.56381 1.000 16.97062 ? 20   VAL   B N   1 
ATOM   3772 C CA  . VAL   B 1 38  ? 14.82470  28.07082  -40.07585 1.000 13.99888 ? 20   VAL   B CA  1 
ATOM   3773 C C   . VAL   B 1 38  ? 15.84519  29.18575  -40.27078 1.000 18.32472 ? 20   VAL   B C   1 
ATOM   3774 O O   . VAL   B 1 38  ? 16.61992  29.50533  -39.36172 1.000 15.10996 ? 20   VAL   B O   1 
ATOM   3775 C CB  . VAL   B 1 38  ? 15.24905  26.76442  -40.77128 1.000 14.83067 ? 20   VAL   B CB  1 
ATOM   3776 C CG1 . VAL   B 1 38  ? 16.64572  26.33869  -40.32411 1.000 21.71315 ? 20   VAL   B CG1 1 
ATOM   3777 C CG2 . VAL   B 1 38  ? 14.23197  25.65606  -40.47905 1.000 13.60235 ? 20   VAL   B CG2 1 
ATOM   3778 N N   . ARG   B 1 39  ? 15.83451  29.82549  -41.44070 1.000 15.55920 ? 21   ARG   B N   1 
ATOM   3779 C CA  . ARG   B 1 39  ? 16.78133  30.91183  -41.68713 1.000 16.53890 ? 21   ARG   B CA  1 
ATOM   3780 C C   . ARG   B 1 39  ? 16.57458  32.07045  -40.71921 1.000 15.87413 ? 21   ARG   B C   1 
ATOM   3781 O O   . ARG   B 1 39  ? 17.54803  32.72139  -40.31482 1.000 14.39530 ? 21   ARG   B O   1 
ATOM   3782 C CB  . ARG   B 1 39  ? 16.65994  31.38313  -43.13556 1.000 20.82262 ? 21   ARG   B CB  1 
ATOM   3783 C CG  . ARG   B 1 39  ? 17.13231  30.33548  -44.14740 1.000 30.69688 ? 21   ARG   B CG  1 
ATOM   3784 C CD  . ARG   B 1 39  ? 17.07314  30.76482  -45.62774 1.000 39.56570 ? 21   ARG   B CD  1 
ATOM   3785 N NE  . ARG   B 1 39  ? 17.55366  32.11648  -45.90360 1.000 50.14784 ? 21   ARG   B NE  1 
ATOM   3786 C CZ  . ARG   B 1 39  ? 16.80927  33.21497  -45.86178 1.000 52.83617 ? 21   ARG   B CZ  1 
ATOM   3787 N NH1 . ARG   B 1 39  ? 15.50806  33.16213  -45.62012 1.000 49.30963 ? 21   ARG   B NH1 1 
ATOM   3788 N NH2 . ARG   B 1 39  ? 17.38084  34.39453  -46.09111 1.000 45.88863 ? 21   ARG   B NH2 1 
ATOM   3789 N N   . LEU   B 1 40  ? 15.32393  32.33604  -40.32648 1.000 15.43167 ? 22   LEU   B N   1 
ATOM   3790 C CA  . LEU   B 1 40  ? 15.06344  33.35341  -39.30664 1.000 19.86493 ? 22   LEU   B CA  1 
ATOM   3791 C C   . LEU   B 1 40  ? 15.67898  32.96274  -37.96579 1.000 15.21429 ? 22   LEU   B C   1 
ATOM   3792 O O   . LEU   B 1 40  ? 16.29679  33.79154  -37.28545 1.000 12.38357 ? 22   LEU   B O   1 
ATOM   3793 C CB  . LEU   B 1 40  ? 13.55203  33.57885  -39.15074 1.000 14.02819 ? 22   LEU   B CB  1 
ATOM   3794 C CG  . LEU   B 1 40  ? 13.14148  34.53154  -38.01725 1.000 15.55581 ? 22   LEU   B CG  1 
ATOM   3795 C CD1 . LEU   B 1 40  ? 13.62771  35.94380  -38.29662 1.000 19.43777 ? 22   LEU   B CD1 1 
ATOM   3796 C CD2 . LEU   B 1 40  ? 11.62477  34.51880  -37.79176 1.000 20.28431 ? 22   LEU   B CD2 1 
ATOM   3797 N N   . PHE   B 1 41  ? 15.49439  31.70797  -37.55514 1.000 12.46365 ? 23   PHE   B N   1 
ATOM   3798 C CA  . PHE   B 1 41  ? 16.06459  31.26513  -36.28789 1.000 14.35571 ? 23   PHE   B CA  1 
ATOM   3799 C C   . PHE   B 1 41  ? 17.58854  31.32396  -36.32722 1.000 17.16701 ? 23   PHE   B C   1 
ATOM   3800 O O   . PHE   B 1 41  ? 18.22556  31.76743  -35.36330 1.000 16.35605 ? 23   PHE   B O   1 
ATOM   3801 C CB  . PHE   B 1 41  ? 15.58267  29.84767  -35.96119 1.000 16.59416 ? 23   PHE   B CB  1 
ATOM   3802 C CG  . PHE   B 1 41  ? 14.27466  29.81493  -35.21172 1.000 15.90951 ? 23   PHE   B CG  1 
ATOM   3803 C CD1 . PHE   B 1 41  ? 13.08094  30.04083  -35.87822 1.000 8.90852  ? 23   PHE   B CD1 1 
ATOM   3804 C CD2 . PHE   B 1 41  ? 14.24348  29.58381  -33.84197 1.000 15.70817 ? 23   PHE   B CD2 1 
ATOM   3805 C CE1 . PHE   B 1 41  ? 11.86727  30.03096  -35.19598 1.000 12.98212 ? 23   PHE   B CE1 1 
ATOM   3806 C CE2 . PHE   B 1 41  ? 13.03151  29.56712  -33.14496 1.000 13.42637 ? 23   PHE   B CE2 1 
ATOM   3807 C CZ  . PHE   B 1 41  ? 11.84429  29.79965  -33.81996 1.000 12.76828 ? 23   PHE   B CZ  1 
ATOM   3808 N N   . ALA   B 1 42  ? 18.18609  30.88768  -37.44199 1.000 17.53818 ? 24   ALA   B N   1 
ATOM   3809 C CA  . ALA   B 1 42  ? 19.63838  30.94905  -37.58762 1.000 16.04282 ? 24   ALA   B CA  1 
ATOM   3810 C C   . ALA   B 1 42  ? 20.14254  32.37721  -37.43650 1.000 17.08952 ? 24   ALA   B C   1 
ATOM   3811 O O   . ALA   B 1 42  ? 21.13165  32.62430  -36.73308 1.000 18.96641 ? 24   ALA   B O   1 
ATOM   3812 C CB  . ALA   B 1 42  ? 20.05052  30.36481  -38.94177 1.000 10.80907 ? 24   ALA   B CB  1 
ATOM   3813 N N   . ALA   B 1 43  ? 19.45277  33.33468  -38.06122 1.000 13.94330 ? 25   ALA   B N   1 
ATOM   3814 C CA  . ALA   B 1 43  ? 19.85073  34.73213  -37.94976 1.000 17.06884 ? 25   ALA   B CA  1 
ATOM   3815 C C   . ALA   B 1 43  ? 19.75218  35.20498  -36.50847 1.000 25.24754 ? 25   ALA   B C   1 
ATOM   3816 O O   . ALA   B 1 43  ? 20.68915  35.81196  -35.97720 1.000 19.79200 ? 25   ALA   B O   1 
ATOM   3817 C CB  . ALA   B 1 43  ? 18.99048  35.60564  -38.86836 1.000 20.43045 ? 25   ALA   B CB  1 
ATOM   3818 N N   . GLU   B 1 44  ? 18.62954  34.90832  -35.84320 1.000 16.68572 ? 26   GLU   B N   1 
ATOM   3819 C CA  . GLU   B 1 44  ? 18.47716  35.33857  -34.45500 1.000 20.24357 ? 26   GLU   B CA  1 
ATOM   3820 C C   . GLU   B 1 44  ? 19.52296  34.68391  -33.55226 1.000 18.20257 ? 26   GLU   B C   1 
ATOM   3821 O O   . GLU   B 1 44  ? 20.07809  35.33611  -32.65822 1.000 16.11060 ? 26   GLU   B O   1 
ATOM   3822 C CB  . GLU   B 1 44  ? 17.06013  35.03419  -33.95732 1.000 14.97627 ? 26   GLU   B CB  1 
ATOM   3823 C CG  . GLU   B 1 44  ? 16.00141  35.97436  -34.52946 1.000 15.40383 ? 26   GLU   B CG  1 
ATOM   3824 C CD  . GLU   B 1 44  ? 16.31527  37.42575  -34.22447 1.000 13.59829 ? 26   GLU   B CD  1 
ATOM   3825 O OE1 . GLU   B 1 44  ? 16.46847  37.77190  -33.03494 1.000 19.11971 ? 26   GLU   B OE1 1 
ATOM   3826 O OE2 . GLU   B 1 44  ? 16.43721  38.22878  -35.17465 1.000 26.04085 ? 26   GLU   B OE2 1 
ATOM   3827 N N   . LEU   B 1 45  ? 19.82023  33.40080  -33.77934 1.000 16.56060 ? 27   LEU   B N   1 
ATOM   3828 C CA  . LEU   B 1 45  ? 20.78228  32.70996  -32.91977 1.000 17.94601 ? 27   LEU   B CA  1 
ATOM   3829 C C   . LEU   B 1 45  ? 22.21213  33.21136  -33.10712 1.000 21.04193 ? 27   LEU   B C   1 
ATOM   3830 O O   . LEU   B 1 45  ? 23.06370  32.94357  -32.25429 1.000 20.94898 ? 27   LEU   B O   1 
ATOM   3831 C CB  . LEU   B 1 45  ? 20.71654  31.20686  -33.17338 1.000 15.10484 ? 27   LEU   B CB  1 
ATOM   3832 C CG  . LEU   B 1 45  ? 19.44939  30.57740  -32.59571 1.000 16.04042 ? 27   LEU   B CG  1 
ATOM   3833 C CD1 . LEU   B 1 45  ? 19.23787  29.17414  -33.16214 1.000 14.24195 ? 27   LEU   B CD1 1 
ATOM   3834 C CD2 . LEU   B 1 45  ? 19.48382  30.58048  -31.05068 1.000 12.74471 ? 27   LEU   B CD2 1 
ATOM   3835 N N   . GLY   B 1 46  ? 22.49863  33.92136  -34.19440 1.000 22.00687 ? 28   GLY   B N   1 
ATOM   3836 C CA  . GLY   B 1 46  ? 23.78524  34.56694  -34.37611 1.000 22.90194 ? 28   GLY   B CA  1 
ATOM   3837 C C   . GLY   B 1 46  ? 23.91902  35.89974  -33.68187 1.000 25.67300 ? 28   GLY   B C   1 
ATOM   3838 O O   . GLY   B 1 46  ? 24.91557  36.60013  -33.85801 1.000 29.14404 ? 28   GLY   B O   1 
ATOM   3839 N N   . ARG   B 1 47  ? 22.92319  36.27462  -32.89224 1.000 26.50496 ? 29   ARG   B N   1 
ATOM   3840 C CA  . ARG   B 1 47  ? 22.90220  37.49813  -32.11355 1.000 23.09960 ? 29   ARG   B CA  1 
ATOM   3841 C C   . ARG   B 1 47  ? 23.11442  37.15187  -30.64791 1.000 31.03016 ? 29   ARG   B C   1 
ATOM   3842 O O   . ARG   B 1 47  ? 22.93351  36.00589  -30.23218 1.000 26.05878 ? 29   ARG   B O   1 
ATOM   3843 C CB  . ARG   B 1 47  ? 21.56447  38.21697  -32.31774 1.000 30.68658 ? 29   ARG   B CB  1 
ATOM   3844 C CG  . ARG   B 1 47  ? 21.35994  38.61503  -33.76575 1.000 30.17703 ? 29   ARG   B CG  1 
ATOM   3845 C CD  . ARG   B 1 47  ? 20.33191  39.70721  -33.94046 1.000 37.94416 ? 29   ARG   B CD  1 
ATOM   3846 N NE  . ARG   B 1 47  ? 19.29887  39.31069  -34.89301 1.000 43.50773 ? 29   ARG   B NE  1 
ATOM   3847 C CZ  . ARG   B 1 47  ? 19.44654  39.35148  -36.21316 1.000 51.18372 ? 29   ARG   B CZ  1 
ATOM   3848 N NH1 . ARG   B 1 47  ? 20.56703  39.78863  -36.77082 1.000 55.16610 ? 29   ARG   B NH1 1 
ATOM   3849 N NH2 . ARG   B 1 47  ? 18.44684  38.94272  -36.99372 1.000 39.82085 ? 29   ARG   B NH2 1 
ATOM   3850 N N   . GLU   B 1 48  ? 23.50460  38.15150  -29.85616 1.000 30.05303 ? 30   GLU   B N   1 
ATOM   3851 C CA  . GLU   B 1 48  ? 23.67058  37.90066  -28.42811 1.000 29.42350 ? 30   GLU   B CA  1 
ATOM   3852 C C   . GLU   B 1 48  ? 22.32741  37.75910  -27.72949 1.000 34.55830 ? 30   GLU   B C   1 
ATOM   3853 O O   . GLU   B 1 48  ? 22.21202  37.04755  -26.72322 1.000 30.04327 ? 30   GLU   B O   1 
ATOM   3854 C CB  . GLU   B 1 48  ? 24.49158  39.01658  -27.78827 1.000 44.18716 ? 30   GLU   B CB  1 
ATOM   3855 C CG  . GLU   B 1 48  ? 25.93644  39.02708  -28.25343 1.000 47.21893 ? 30   GLU   B CG  1 
ATOM   3856 C CD  . GLU   B 1 48  ? 26.69539  40.23235  -27.75673 1.000 60.34377 ? 30   GLU   B CD  1 
ATOM   3857 O OE1 . GLU   B 1 48  ? 26.67947  40.47516  -26.53026 1.000 55.25330 ? 30   GLU   B OE1 1 
ATOM   3858 O OE2 . GLU   B 1 48  ? 27.29909  40.93767  -28.59245 1.000 65.05570 ? 30   GLU   B OE2 1 
ATOM   3859 N N   . GLU   B 1 49  ? 21.30378  38.41777  -28.24007 1.000 24.26787 ? 31   GLU   B N   1 
ATOM   3860 C CA  . GLU   B 1 49  ? 19.96439  38.31975  -27.67862 1.000 23.80316 ? 31   GLU   B CA  1 
ATOM   3861 C C   . GLU   B 1 49  ? 19.01965  37.95602  -28.81088 1.000 20.58926 ? 31   GLU   B C   1 
ATOM   3862 O O   . GLU   B 1 49  ? 18.39713  38.83742  -29.41678 1.000 22.68626 ? 31   GLU   B O   1 
ATOM   3863 C CB  . GLU   B 1 49  ? 19.55738  39.62205  -26.99140 1.000 27.80169 ? 31   GLU   B CB  1 
ATOM   3864 C CG  . GLU   B 1 49  ? 20.38062  39.93029  -25.75483 1.000 29.56424 ? 31   GLU   B CG  1 
ATOM   3865 C CD  . GLU   B 1 49  ? 19.77876  39.34943  -24.49022 1.000 24.39924 ? 31   GLU   B CD  1 
ATOM   3866 O OE1 . GLU   B 1 49  ? 18.60614  38.91758  -24.51732 1.000 25.43386 ? 31   GLU   B OE1 1 
ATOM   3867 O OE2 . GLU   B 1 49  ? 20.48566  39.31530  -23.46263 1.000 35.28579 ? 31   GLU   B OE2 1 
ATOM   3868 N N   . PRO   B 1 50  ? 18.90858  36.66940  -29.14343 1.000 20.84623 ? 32   PRO   B N   1 
ATOM   3869 C CA  . PRO   B 1 50  ? 17.80798  36.24003  -30.00913 1.000 17.50949 ? 32   PRO   B CA  1 
ATOM   3870 C C   . PRO   B 1 50  ? 16.49027  36.71165  -29.41976 1.000 15.76934 ? 32   PRO   B C   1 
ATOM   3871 O O   . PRO   B 1 50  ? 16.26335  36.63265  -28.20877 1.000 13.35529 ? 32   PRO   B O   1 
ATOM   3872 C CB  . PRO   B 1 50  ? 17.91602  34.70971  -30.01538 1.000 18.59531 ? 32   PRO   B CB  1 
ATOM   3873 C CG  . PRO   B 1 50  ? 18.87501  34.36572  -28.90996 1.000 21.51533 ? 32   PRO   B CG  1 
ATOM   3874 C CD  . PRO   B 1 50  ? 19.75098  35.54465  -28.70502 1.000 17.50485 ? 32   PRO   B CD  1 
ATOM   3875 N N   . ASP   B 1 51  ? 15.63320  37.23225  -30.28943 1.000 10.18138 ? 33   ASP   B N   1 
ATOM   3876 C CA  . ASP   B 1 51  ? 14.37845  37.85375  -29.88331 1.000 11.29067 ? 33   ASP   B CA  1 
ATOM   3877 C C   . ASP   B 1 51  ? 13.36984  36.75181  -29.59255 1.000 13.61682 ? 33   ASP   B C   1 
ATOM   3878 O O   . ASP   B 1 51  ? 12.76161  36.19735  -30.50768 1.000 13.40795 ? 33   ASP   B O   1 
ATOM   3879 C CB  . ASP   B 1 51  ? 13.88586  38.79506  -30.97653 1.000 16.17809 ? 33   ASP   B CB  1 
ATOM   3880 C CG  . ASP   B 1 51  ? 12.77443  39.70148  -30.50223 1.000 22.18562 ? 33   ASP   B CG  1 
ATOM   3881 O OD1 . ASP   B 1 51  ? 11.88040  39.21242  -29.78158 1.000 13.48044 ? 33   ASP   B OD1 1 
ATOM   3882 O OD2 . ASP   B 1 51  ? 12.79078  40.90282  -30.84504 1.000 17.39416 ? 33   ASP   B OD2 1 
ATOM   3883 N N   . LEU   B 1 52  ? 13.18514  36.44516  -28.30447 1.000 15.60907 ? 34   LEU   B N   1 
ATOM   3884 C CA  . LEU   B 1 52  ? 12.29967  35.35243  -27.90452 1.000 11.13958 ? 34   LEU   B CA  1 
ATOM   3885 C C   . LEU   B 1 52  ? 10.85247  35.64328  -28.27913 1.000 15.21057 ? 34   LEU   B C   1 
ATOM   3886 O O   . LEU   B 1 52  ? 10.10978  34.73359  -28.66779 1.000 13.31261 ? 34   LEU   B O   1 
ATOM   3887 C CB  . LEU   B 1 52  ? 12.40137  35.12983  -26.40072 1.000 12.84255 ? 34   LEU   B CB  1 
ATOM   3888 C CG  . LEU   B 1 52  ? 13.73376  34.67262  -25.81923 1.000 12.96859 ? 34   LEU   B CG  1 
ATOM   3889 C CD1 . LEU   B 1 52  ? 13.62139  34.63183  -24.30679 1.000 13.37407 ? 34   LEU   B CD1 1 
ATOM   3890 C CD2 . LEU   B 1 52  ? 14.10053  33.31420  -26.38097 1.000 12.98339 ? 34   LEU   B CD2 1 
ATOM   3891 N N   . VAL   B 1 53  ? 10.43164  36.90282  -28.14580 1.000 14.14736 ? 35   VAL   B N   1 
ATOM   3892 C CA  . VAL   B 1 53  ? 9.05543   37.27442  -28.46884 1.000 11.52476 ? 35   VAL   B CA  1 
ATOM   3893 C C   . VAL   B 1 53  ? 8.78687   37.08726  -29.95450 1.000 11.73501 ? 35   VAL   B C   1 
ATOM   3894 O O   . VAL   B 1 53  ? 7.74916   36.53967  -30.35025 1.000 11.82095 ? 35   VAL   B O   1 
ATOM   3895 C CB  . VAL   B 1 53  ? 8.77199   38.72014  -28.02799 1.000 16.64714 ? 35   VAL   B CB  1 
ATOM   3896 C CG1 . VAL   B 1 53  ? 7.44381   39.21788  -28.64265 1.000 15.97854 ? 35   VAL   B CG1 1 
ATOM   3897 C CG2 . VAL   B 1 53  ? 8.73859   38.80057  -26.51227 1.000 16.60142 ? 35   VAL   B CG2 1 
ATOM   3898 N N   . LEU   B 1 54  ? 9.71550   37.54771  -30.79847 1.000 12.77518 ? 36   LEU   B N   1 
ATOM   3899 C CA  . LEU   B 1 54  ? 9.56623   37.37727  -32.24015 1.000 11.23777 ? 36   LEU   B CA  1 
ATOM   3900 C C   . LEU   B 1 54  ? 9.52681   35.90488  -32.61764 1.000 13.48508 ? 36   LEU   B C   1 
ATOM   3901 O O   . LEU   B 1 54  ? 8.67742   35.47424  -33.40287 1.000 10.95418 ? 36   LEU   B O   1 
ATOM   3902 C CB  . LEU   B 1 54  ? 10.70928  38.07815  -32.98160 1.000 11.10236 ? 36   LEU   B CB  1 
ATOM   3903 C CG  . LEU   B 1 54  ? 10.75341  37.83664  -34.49678 1.000 12.06870 ? 36   LEU   B CG  1 
ATOM   3904 C CD1 . LEU   B 1 54  ? 9.50672   38.39104  -35.17507 1.000 16.47808 ? 36   LEU   B CD1 1 
ATOM   3905 C CD2 . LEU   B 1 54  ? 11.99969  38.46141  -35.09630 1.000 20.98204 ? 36   LEU   B CD2 1 
ATOM   3906 N N   . LEU   B 1 55  ? 10.45584  35.11436  -32.07991 1.000 8.24604  ? 37   LEU   B N   1 
ATOM   3907 C CA  . LEU   B 1 55  ? 10.53241  33.71954  -32.49659 1.000 13.65910 ? 37   LEU   B CA  1 
ATOM   3908 C C   . LEU   B 1 55  ? 9.31748   32.92959  -32.02286 1.000 11.84550 ? 37   LEU   B C   1 
ATOM   3909 O O   . LEU   B 1 55  ? 8.79546   32.08777  -32.76270 1.000 11.00820 ? 37   LEU   B O   1 
ATOM   3910 C CB  . LEU   B 1 55  ? 11.82516  33.09504  -31.97710 1.000 12.46644 ? 37   LEU   B CB  1 
ATOM   3911 C CG  . LEU   B 1 55  ? 13.12248  33.66134  -32.55195 1.000 13.45529 ? 37   LEU   B CG  1 
ATOM   3912 C CD1 . LEU   B 1 55  ? 14.34397  33.11364  -31.77639 1.000 12.61733 ? 37   LEU   B CD1 1 
ATOM   3913 C CD2 . LEU   B 1 55  ? 13.24856  33.33767  -34.02465 1.000 10.91094 ? 37   LEU   B CD2 1 
ATOM   3914 N N   . SER   B 1 56  ? 8.85670   33.17536  -30.79057 1.000 12.01052 ? 38   SER   B N   1 
ATOM   3915 C CA  . SER   B 1 56  ? 7.70024   32.43384  -30.28707 1.000 9.63298  ? 38   SER   B CA  1 
ATOM   3916 C C   . SER   B 1 56  ? 6.43293   32.82051  -31.03819 1.000 11.03040 ? 38   SER   B C   1 
ATOM   3917 O O   . SER   B 1 56  ? 5.56431   31.97414  -31.28965 1.000 14.68211 ? 38   SER   B O   1 
ATOM   3918 C CB  . SER   B 1 56  ? 7.52022   32.67931  -28.78468 1.000 10.64473 ? 38   SER   B CB  1 
ATOM   3919 O OG  . SER   B 1 56  ? 6.38805   31.97108  -28.28332 1.000 11.45063 ? 38   SER   B OG  1 
ATOM   3920 N N   . LEU   B 1 57  ? 6.30250   34.09862  -31.39458 1.000 12.05596 ? 39   LEU   B N   1 
ATOM   3921 C CA  . LEU   B 1 57  ? 5.14647   34.52612  -32.17520 1.000 12.86968 ? 39   LEU   B CA  1 
ATOM   3922 C C   . LEU   B 1 57  ? 5.10511   33.81141  -33.51410 1.000 11.11825 ? 39   LEU   B C   1 
ATOM   3923 O O   . LEU   B 1 57  ? 4.03847   33.37724  -33.95920 1.000 11.81938 ? 39   LEU   B O   1 
ATOM   3924 C CB  . LEU   B 1 57  ? 5.17374   36.04112  -32.38692 1.000 14.81396 ? 39   LEU   B CB  1 
ATOM   3925 C CG  . LEU   B 1 57  ? 4.70465   36.90928  -31.21856 1.000 22.17239 ? 39   LEU   B CG  1 
ATOM   3926 C CD1 . LEU   B 1 57  ? 4.95794   38.37277  -31.54518 1.000 20.71001 ? 39   LEU   B CD1 1 
ATOM   3927 C CD2 . LEU   B 1 57  ? 3.22496   36.66292  -30.89352 1.000 26.39569 ? 39   LEU   B CD2 1 
ATOM   3928 N N   . VAL   B 1 58  ? 6.26038   33.66983  -34.16748 1.000 8.21858  ? 40   VAL   B N   1 
ATOM   3929 C CA  . VAL   B 1 58  ? 6.30145   32.99482  -35.46087 1.000 11.20488 ? 40   VAL   B CA  1 
ATOM   3930 C C   . VAL   B 1 58  ? 5.90268   31.52442  -35.31445 1.000 12.34093 ? 40   VAL   B C   1 
ATOM   3931 O O   . VAL   B 1 58  ? 5.08738   31.00533  -36.08570 1.000 9.10716  ? 40   VAL   B O   1 
ATOM   3932 C CB  . VAL   B 1 58  ? 7.69397   33.14767  -36.10106 1.000 16.62146 ? 40   VAL   B CB  1 
ATOM   3933 C CG1 . VAL   B 1 58  ? 7.86671   32.15188  -37.24077 1.000 15.69151 ? 40   VAL   B CG1 1 
ATOM   3934 C CG2 . VAL   B 1 58  ? 7.90938   34.59018  -36.58595 1.000 15.27779 ? 40   VAL   B CG2 1 
ATOM   3935 N N   . LEU   B 1 59  ? 6.48044   30.82516  -34.33340 1.000 9.20197  ? 41   LEU   B N   1 
ATOM   3936 C CA  . LEU   B 1 59  ? 6.13517   29.41606  -34.15069 1.000 12.12121 ? 41   LEU   B CA  1 
ATOM   3937 C C   . LEU   B 1 59  ? 4.66599   29.24597  -33.79335 1.000 13.55334 ? 41   LEU   B C   1 
ATOM   3938 O O   . LEU   B 1 59  ? 4.00827   28.31383  -34.26931 1.000 11.64802 ? 41   LEU   B O   1 
ATOM   3939 C CB  . LEU   B 1 59  ? 7.01211   28.78545  -33.06849 1.000 11.37285 ? 41   LEU   B CB  1 
ATOM   3940 C CG  . LEU   B 1 59  ? 8.49181   28.62704  -33.38223 1.000 11.51480 ? 41   LEU   B CG  1 
ATOM   3941 C CD1 . LEU   B 1 59  ? 9.20535   27.95013  -32.20888 1.000 9.86871  ? 41   LEU   B CD1 1 
ATOM   3942 C CD2 . LEU   B 1 59  ? 8.69075   27.86058  -34.68209 1.000 8.96299  ? 41   LEU   B CD2 1 
ATOM   3943 N N   . GLY   B 1 60  ? 4.13381   30.13060  -32.95184 1.000 12.06119 ? 42   GLY   B N   1 
ATOM   3944 C CA  . GLY   B 1 60  ? 2.72784   30.03168  -32.58657 1.000 12.76410 ? 42   GLY   B CA  1 
ATOM   3945 C C   . GLY   B 1 60  ? 1.79151   30.35005  -33.74119 1.000 14.01382 ? 42   GLY   B C   1 
ATOM   3946 O O   . GLY   B 1 60  ? 0.73871   29.72217  -33.88738 1.000 12.20997 ? 42   GLY   B O   1 
ATOM   3947 N N   . PHE   B 1 61  ? 2.15407   31.33727  -34.56612 1.000 11.94678 ? 43   PHE   B N   1 
ATOM   3948 C CA  . PHE   B 1 61  ? 1.38080   31.62952  -35.77274 1.000 14.82264 ? 43   PHE   B CA  1 
ATOM   3949 C C   . PHE   B 1 61  ? 1.33990   30.41044  -36.68835 1.000 11.66279 ? 43   PHE   B C   1 
ATOM   3950 O O   . PHE   B 1 61  ? 0.27009   29.96274  -37.12350 1.000 11.88843 ? 43   PHE   B O   1 
ATOM   3951 C CB  . PHE   B 1 61  ? 1.99662   32.83165  -36.50381 1.000 10.97195 ? 43   PHE   B CB  1 
ATOM   3952 C CG  . PHE   B 1 61  ? 1.36648   33.11227  -37.84598 1.000 13.30615 ? 43   PHE   B CG  1 
ATOM   3953 C CD1 . PHE   B 1 61  ? 0.24618   33.92059  -37.93717 1.000 12.17327 ? 43   PHE   B CD1 1 
ATOM   3954 C CD2 . PHE   B 1 61  ? 1.87700   32.55107  -39.00349 1.000 15.95482 ? 43   PHE   B CD2 1 
ATOM   3955 C CE1 . PHE   B 1 61  ? -0.35369  34.16855  -39.16510 1.000 17.35068 ? 43   PHE   B CE1 1 
ATOM   3956 C CE2 . PHE   B 1 61  ? 1.27977   32.79236  -40.23846 1.000 15.33065 ? 43   PHE   B CE2 1 
ATOM   3957 C CZ  . PHE   B 1 61  ? 0.16329   33.60747  -40.31198 1.000 14.30029 ? 43   PHE   B CZ  1 
ATOM   3958 N N   . VAL   B 1 62  ? 2.50975   29.84159  -36.96099 1.000 9.56731  ? 44   VAL   B N   1 
ATOM   3959 C CA  . VAL   B 1 62  ? 2.62647   28.72822  -37.89082 1.000 10.02454 ? 44   VAL   B CA  1 
ATOM   3960 C C   . VAL   B 1 62  ? 1.92811   27.49047  -37.33867 1.000 16.29412 ? 44   VAL   B C   1 
ATOM   3961 O O   . VAL   B 1 62  ? 1.25269   26.75891  -38.07521 1.000 12.73602 ? 44   VAL   B O   1 
ATOM   3962 C CB  . VAL   B 1 62  ? 4.12165   28.48942  -38.16961 1.000 15.40386 ? 44   VAL   B CB  1 
ATOM   3963 C CG1 . VAL   B 1 62  ? 4.37444   27.11236  -38.72721 1.000 23.60867 ? 44   VAL   B CG1 1 
ATOM   3964 C CG2 . VAL   B 1 62  ? 4.68460   29.61015  -39.07540 1.000 13.62482 ? 44   VAL   B CG2 1 
ATOM   3965 N N   . GLU   B 1 63  ? 2.04939   27.24898  -36.02633 1.000 9.84081  ? 45   GLU   B N   1 
ATOM   3966 C CA  . GLU   B 1 63  ? 1.36940   26.09355  -35.44552 1.000 9.99796  ? 45   GLU   B CA  1 
ATOM   3967 C C   . GLU   B 1 63  ? -0.13914  26.28445  -35.44946 1.000 13.36706 ? 45   GLU   B C   1 
ATOM   3968 O O   . GLU   B 1 63  ? -0.89110  25.31597  -35.63263 1.000 13.44370 ? 45   GLU   B O   1 
ATOM   3969 C CB  . GLU   B 1 63  ? 1.88170   25.85268  -34.02419 1.000 11.21760 ? 45   GLU   B CB  1 
ATOM   3970 C CG  . GLU   B 1 63  ? 1.18926   24.72035  -33.28428 1.000 13.60282 ? 45   GLU   B CG  1 
ATOM   3971 C CD  . GLU   B 1 63  ? 1.94015   24.29901  -32.02137 1.000 13.92483 ? 45   GLU   B CD  1 
ATOM   3972 O OE1 . GLU   B 1 63  ? 3.19043   24.27534  -32.05634 1.000 12.60332 ? 45   GLU   B OE1 1 
ATOM   3973 O OE2 . GLU   B 1 63  ? 1.27580   23.99591  -30.99671 1.000 12.40576 ? 45   GLU   B OE2 1 
ATOM   3974 N N   . HIS   B 1 64  ? -0.60241  27.52342  -35.26782 1.000 10.32588 ? 46   HIS   B N   1 
ATOM   3975 C CA  . HIS   B 1 64  ? -2.03948  27.74104  -35.23804 1.000 12.33645 ? 46   HIS   B CA  1 
ATOM   3976 C C   . HIS   B 1 64  ? -2.67935  27.33757  -36.55285 1.000 13.87528 ? 46   HIS   B C   1 
ATOM   3977 O O   . HIS   B 1 64  ? -3.72141  26.67026  -36.56823 1.000 12.76260 ? 46   HIS   B O   1 
ATOM   3978 C CB  . HIS   B 1 64  ? -2.36644  29.19878  -34.92800 1.000 12.24410 ? 46   HIS   B CB  1 
ATOM   3979 C CG  . HIS   B 1 64  ? -3.82763  29.50111  -35.04008 1.000 13.92721 ? 46   HIS   B CG  1 
ATOM   3980 N ND1 . HIS   B 1 64  ? -4.70662  29.31295  -33.99473 1.000 17.71236 ? 46   HIS   B ND1 1 
ATOM   3981 C CD2 . HIS   B 1 64  ? -4.57077  29.93673  -36.08423 1.000 18.95610 ? 46   HIS   B CD2 1 
ATOM   3982 C CE1 . HIS   B 1 64  ? -5.92722  29.64309  -34.38349 1.000 21.97676 ? 46   HIS   B CE1 1 
ATOM   3983 N NE2 . HIS   B 1 64  ? -5.87240  30.01988  -35.64890 1.000 20.54728 ? 46   HIS   B NE2 1 
ATOM   3984 N N   . PHE   B 1 65  ? -2.07112  27.72762  -37.66745 1.000 10.71182 ? 47   PHE   B N   1 
ATOM   3985 C CA  . PHE   B 1 65  ? -2.66583  27.46206  -38.96775 1.000 12.87822 ? 47   PHE   B CA  1 
ATOM   3986 C C   . PHE   B 1 65  ? -2.24159  26.12429  -39.55110 1.000 17.23599 ? 47   PHE   B C   1 
ATOM   3987 O O   . PHE   B 1 65  ? -2.71721  25.75536  -40.62737 1.000 24.00151 ? 47   PHE   B O   1 
ATOM   3988 C CB  . PHE   B 1 65  ? -2.34884  28.61283  -39.93477 1.000 14.84373 ? 47   PHE   B CB  1 
ATOM   3989 C CG  . PHE   B 1 65  ? -3.18434  29.83407  -39.68146 1.000 17.57957 ? 47   PHE   B CG  1 
ATOM   3990 C CD1 . PHE   B 1 65  ? -4.56720  29.79614  -39.88970 1.000 16.77571 ? 47   PHE   B CD1 1 
ATOM   3991 C CD2 . PHE   B 1 65  ? -2.60839  31.00310  -39.20989 1.000 18.67006 ? 47   PHE   B CD2 1 
ATOM   3992 C CE1 . PHE   B 1 65  ? -5.35377  30.91017  -39.64019 1.000 19.36461 ? 47   PHE   B CE1 1 
ATOM   3993 C CE2 . PHE   B 1 65  ? -3.38383  32.12095  -38.95136 1.000 18.43010 ? 47   PHE   B CE2 1 
ATOM   3994 C CZ  . PHE   B 1 65  ? -4.76660  32.07486  -39.17255 1.000 21.21921 ? 47   PHE   B CZ  1 
ATOM   3995 N N   . LEU   B 1 66  ? -1.38713  25.37434  -38.85633 1.000 10.17132 ? 48   LEU   B N   1 
ATOM   3996 C CA  . LEU   B 1 66  ? -1.05527  24.01606  -39.26400 1.000 10.63691 ? 48   LEU   B CA  1 
ATOM   3997 C C   . LEU   B 1 66  ? -1.65232  22.93998  -38.36913 1.000 15.54874 ? 48   LEU   B C   1 
ATOM   3998 O O   . LEU   B 1 66  ? -1.75713  21.78755  -38.80626 1.000 17.22404 ? 48   LEU   B O   1 
ATOM   3999 C CB  . LEU   B 1 66  ? 0.46939   23.82720  -39.31312 1.000 12.76077 ? 48   LEU   B CB  1 
ATOM   4000 C CG  . LEU   B 1 66  ? 1.11922   24.39531  -40.58374 1.000 16.28552 ? 48   LEU   B CG  1 
ATOM   4001 C CD1 . LEU   B 1 66  ? 2.61117   24.56954  -40.40402 1.000 15.74579 ? 48   LEU   B CD1 1 
ATOM   4002 C CD2 . LEU   B 1 66  ? 0.84109   23.48196  -41.77092 1.000 18.36564 ? 48   LEU   B CD2 1 
ATOM   4003 N N   . ALA   B 1 67  ? -2.03128  23.26971  -37.13373 1.000 15.05292 ? 49   ALA   B N   1 
ATOM   4004 C CA  . ALA   B 1 67  ? -2.49860  22.22775  -36.22540 1.000 12.66695 ? 49   ALA   B CA  1 
ATOM   4005 C C   . ALA   B 1 67  ? -3.76865  22.62753  -35.49016 1.000 17.41489 ? 49   ALA   B C   1 
ATOM   4006 O O   . ALA   B 1 67  ? -4.62166  21.77132  -35.24294 1.000 22.18639 ? 49   ALA   B O   1 
ATOM   4007 C CB  . ALA   B 1 67  ? -1.41467  21.84650  -35.21837 1.000 14.16313 ? 49   ALA   B CB  1 
ATOM   4008 N N   . VAL   B 1 68  ? -3.91813  23.90188  -35.12706 1.000 12.76071 ? 50   VAL   B N   1 
ATOM   4009 C CA  . VAL   B 1 68  ? -5.14950  24.33371  -34.46405 1.000 14.70394 ? 50   VAL   B CA  1 
ATOM   4010 C C   . VAL   B 1 68  ? -6.28720  24.41361  -35.47116 1.000 19.86322 ? 50   VAL   B C   1 
ATOM   4011 O O   . VAL   B 1 68  ? -7.30142  23.71652  -35.35688 1.000 22.12325 ? 50   VAL   B O   1 
ATOM   4012 C CB  . VAL   B 1 68  ? -4.94353  25.67933  -33.74475 1.000 17.06571 ? 50   VAL   B CB  1 
ATOM   4013 C CG1 . VAL   B 1 68  ? -6.24504  26.14611  -33.09928 1.000 16.34396 ? 50   VAL   B CG1 1 
ATOM   4014 C CG2 . VAL   B 1 68  ? -3.83408  25.57270  -32.70308 1.000 9.66558  ? 50   VAL   B CG2 1 
ATOM   4015 N N   . ASN   B 1 69  ? -6.11670  25.25290  -36.47880 1.000 17.53565 ? 51   ASN   B N   1 
ATOM   4016 C CA  . ASN   B 1 69  ? -7.03767  25.40598  -37.59805 1.000 18.66948 ? 51   ASN   B CA  1 
ATOM   4017 C C   . ASN   B 1 69  ? -6.36231  24.72956  -38.78905 1.000 23.40338 ? 51   ASN   B C   1 
ATOM   4018 O O   . ASN   B 1 69  ? -5.58164  25.35597  -39.50765 1.000 31.91300 ? 51   ASN   B O   1 
ATOM   4019 C CB  . ASN   B 1 69  ? -7.30724  26.90724  -37.84945 1.000 16.89616 ? 51   ASN   B CB  1 
ATOM   4020 C CG  . ASN   B 1 69  ? -8.27134  27.16164  -39.00656 1.000 33.68362 ? 51   ASN   B CG  1 
ATOM   4021 O OD1 . ASN   B 1 69  ? -8.51237  26.29422  -39.84655 1.000 30.06537 ? 51   ASN   B OD1 1 
ATOM   4022 N ND2 . ASN   B 1 69  ? -8.81218  28.37477  -39.05832 1.000 33.88664 ? 51   ASN   B ND2 1 
ATOM   4023 N N   . ARG   B 1 70  ? -6.63958  23.43996  -38.98529 1.000 18.44052 ? 52   ARG   B N   1 
ATOM   4024 C CA  . ARG   B 1 70  ? -6.07143  22.71001  -40.11752 1.000 26.09010 ? 52   ARG   B CA  1 
ATOM   4025 C C   . ARG   B 1 70  ? -6.83342  23.11665  -41.37628 1.000 33.28629 ? 52   ARG   B C   1 
ATOM   4026 O O   . ARG   B 1 70  ? -8.01613  22.79380  -41.52793 1.000 27.48111 ? 52   ARG   B O   1 
ATOM   4027 C CB  . ARG   B 1 70  ? -6.14226  21.20182  -39.88167 1.000 21.58554 ? 52   ARG   B CB  1 
ATOM   4028 C CG  . ARG   B 1 70  ? -5.49255  20.35454  -40.97754 1.000 21.16126 ? 52   ARG   B CG  1 
ATOM   4029 C CD  . ARG   B 1 70  ? -3.98308  20.59321  -40.97867 1.000 27.65115 ? 52   ARG   B CD  1 
ATOM   4030 N NE  . ARG   B 1 70  ? -3.28829  19.94252  -42.08302 1.000 21.91060 ? 52   ARG   B NE  1 
ATOM   4031 C CZ  . ARG   B 1 70  ? -1.97114  19.95451  -42.23735 1.000 22.54908 ? 52   ARG   B CZ  1 
ATOM   4032 N NH1 . ARG   B 1 70  ? -1.17829  20.52636  -41.34448 1.000 13.05978 ? 52   ARG   B NH1 1 
ATOM   4033 N NH2 . ARG   B 1 70  ? -1.43649  19.37871  -43.31181 1.000 21.80804 ? 52   ARG   B NH2 1 
ATOM   4034 N N   . VAL   B 1 71  ? -6.16124  23.83321  -42.27832 1.000 24.44047 ? 53   VAL   B N   1 
ATOM   4035 C CA  . VAL   B 1 71  ? -6.83638  24.38107  -43.45301 1.000 24.69110 ? 53   VAL   B CA  1 
ATOM   4036 C C   . VAL   B 1 71  ? -7.10707  23.29134  -44.48078 1.000 29.60832 ? 53   VAL   B C   1 
ATOM   4037 O O   . VAL   B 1 71  ? -8.20299  23.20285  -45.04521 1.000 32.05673 ? 53   VAL   B O   1 
ATOM   4038 C CB  . VAL   B 1 71  ? -6.00393  25.52409  -44.05963 1.000 30.23628 ? 53   VAL   B CB  1 
ATOM   4039 C CG1 . VAL   B 1 71  ? -6.86079  26.35614  -44.99965 1.000 36.37749 ? 53   VAL   B CG1 1 
ATOM   4040 C CG2 . VAL   B 1 71  ? -5.42785  26.39194  -42.94892 1.000 27.15840 ? 53   VAL   B CG2 1 
ATOM   4041 N N   . ILE   B 1 72  ? -6.10785  22.47324  -44.76431 1.000 25.50592 ? 54   ILE   B N   1 
ATOM   4042 C CA  . ILE   B 1 72  ? -6.19600  21.41165  -45.76312 1.000 28.82226 ? 54   ILE   B CA  1 
ATOM   4043 C C   . ILE   B 1 72  ? -6.17043  20.08255  -45.02623 1.000 28.69300 ? 54   ILE   B C   1 
ATOM   4044 O O   . ILE   B 1 72  ? -5.27970  19.86820  -44.19514 1.000 22.77517 ? 54   ILE   B O   1 
ATOM   4045 C CB  . ILE   B 1 72  ? -5.04336  21.48156  -46.78594 1.000 32.23927 ? 54   ILE   B CB  1 
ATOM   4046 C CG1 . ILE   B 1 72  ? -4.98307  22.84939  -47.48118 1.000 35.63641 ? 54   ILE   B CG1 1 
ATOM   4047 C CG2 . ILE   B 1 72  ? -5.17061  20.36149  -47.81296 1.000 28.92052 ? 54   ILE   B CG2 1 
ATOM   4048 C CD1 . ILE   B 1 72  ? -6.33748  23.43977  -47.83723 1.000 41.34777 ? 54   ILE   B CD1 1 
ATOM   4049 N N   . PRO   B 1 73  ? -7.11722  19.18114  -45.27907 1.000 32.57615 ? 55   PRO   B N   1 
ATOM   4050 C CA  . PRO   B 1 73  ? -7.07117  17.87203  -44.61841 1.000 29.83183 ? 55   PRO   B CA  1 
ATOM   4051 C C   . PRO   B 1 73  ? -5.78902  17.13031  -44.96691 1.000 31.40200 ? 55   PRO   B C   1 
ATOM   4052 O O   . PRO   B 1 73  ? -5.24262  17.26951  -46.06360 1.000 29.57472 ? 55   PRO   B O   1 
ATOM   4053 C CB  . PRO   B 1 73  ? -8.31018  17.14926  -45.16625 1.000 36.27252 ? 55   PRO   B CB  1 
ATOM   4054 C CG  . PRO   B 1 73  ? -9.22534  18.24455  -45.63659 1.000 37.30523 ? 55   PRO   B CG  1 
ATOM   4055 C CD  . PRO   B 1 73  ? -8.31824  19.34731  -46.11732 1.000 35.43505 ? 55   PRO   B CD  1 
ATOM   4056 N N   . THR   B 1 74  ? -5.29482  16.35278  -44.00376 1.000 26.57069 ? 56   THR   B N   1 
ATOM   4057 C CA  . THR   B 1 74  ? -4.12347  15.51264  -44.22029 1.000 32.80356 ? 56   THR   B CA  1 
ATOM   4058 C C   . THR   B 1 74  ? -4.44870  14.21027  -44.94035 1.000 35.22263 ? 56   THR   B C   1 
ATOM   4059 O O   . THR   B 1 74  ? -3.53639  13.40812  -45.16733 1.000 30.49684 ? 56   THR   B O   1 
ATOM   4060 C CB  . THR   B 1 74  ? -3.44218  15.18288  -42.88841 1.000 34.45456 ? 56   THR   B CB  1 
ATOM   4061 O OG1 . THR   B 1 74  ? -4.25058  14.24573  -42.16050 1.000 25.67074 ? 56   THR   B OG1 1 
ATOM   4062 C CG2 . THR   B 1 74  ? -3.23034  16.43872  -42.06359 1.000 28.45602 ? 56   THR   B CG2 1 
ATOM   4063 N N   . ASN   B 1 75  ? -5.70972  13.97973  -45.29886 1.000 30.41858 ? 57   ASN   B N   1 
ATOM   4064 C CA  . ASN   B 1 75  ? -6.08187  12.72111  -45.93158 1.000 40.74583 ? 57   ASN   B CA  1 
ATOM   4065 C C   . ASN   B 1 75  ? -5.31811  12.49248  -47.23370 1.000 42.79130 ? 57   ASN   B C   1 
ATOM   4066 O O   . ASN   B 1 75  ? -5.14839  13.40315  -48.04866 1.000 38.75490 ? 57   ASN   B O   1 
ATOM   4067 C CB  . ASN   B 1 75  ? -7.58328  12.68647  -46.21039 1.000 42.84116 ? 57   ASN   B CB  1 
ATOM   4068 C CG  . ASN   B 1 75  ? -8.03347  11.34407  -46.76564 1.000 58.12548 ? 57   ASN   B CG  1 
ATOM   4069 O OD1 . ASN   B 1 75  ? -7.70900  10.29109  -46.21132 1.000 55.47542 ? 57   ASN   B OD1 1 
ATOM   4070 N ND2 . ASN   B 1 75  ? -8.76265  11.37441  -47.87949 1.000 56.78264 ? 57   ASN   B ND2 1 
ATOM   4071 N N   . VAL   B 1 76  ? -4.86274  11.26288  -47.42068 1.000 36.21596 ? 58   VAL   B N   1 
ATOM   4072 C CA  . VAL   B 1 76  ? -4.27722  10.80699  -48.68027 1.000 33.23056 ? 58   VAL   B CA  1 
ATOM   4073 C C   . VAL   B 1 76  ? -5.33771  10.01038  -49.43067 1.000 34.77172 ? 58   VAL   B C   1 
ATOM   4074 O O   . VAL   B 1 76  ? -5.93261  9.09673   -48.84246 1.000 27.38212 ? 58   VAL   B O   1 
ATOM   4075 C CB  . VAL   B 1 76  ? -3.02128  9.95011   -48.44438 1.000 34.23341 ? 58   VAL   B CB  1 
ATOM   4076 C CG1 . VAL   B 1 76  ? -2.37659  9.56668   -49.77626 1.000 28.55212 ? 58   VAL   B CG1 1 
ATOM   4077 C CG2 . VAL   B 1 76  ? -2.02918  10.69565  -47.55195 1.000 32.79025 ? 58   VAL   B CG2 1 
ATOM   4078 N N   . PRO   B 1 77  ? -5.60534  10.31745  -50.70223 1.000 44.06937 ? 59   PRO   B N   1 
ATOM   4079 C CA  . PRO   B 1 77  ? -6.61567  9.55731   -51.44713 1.000 35.44822 ? 59   PRO   B CA  1 
ATOM   4080 C C   . PRO   B 1 77  ? -6.25019  8.08167   -51.53458 1.000 33.74940 ? 59   PRO   B C   1 
ATOM   4081 O O   . PRO   B 1 77  ? -5.08512  7.69499   -51.41994 1.000 32.72761 ? 59   PRO   B O   1 
ATOM   4082 C CB  . PRO   B 1 77  ? -6.60624  10.21135  -52.83526 1.000 38.24250 ? 59   PRO   B CB  1 
ATOM   4083 C CG  . PRO   B 1 77  ? -5.99469  11.57361  -52.62090 1.000 33.15265 ? 59   PRO   B CG  1 
ATOM   4084 C CD  . PRO   B 1 77  ? -4.99189  11.37824  -51.52496 1.000 28.92319 ? 59   PRO   B CD  1 
ATOM   4085 N N   . GLU   B 1 78  ? -7.27841  7.25159   -51.72648 1.000 44.77794 ? 60   GLU   B N   1 
ATOM   4086 C CA  . GLU   B 1 78  ? -7.06670  5.82553   -51.94739 1.000 44.05270 ? 60   GLU   B CA  1 
ATOM   4087 C C   . GLU   B 1 78  ? -6.14801  5.62154   -53.14384 1.000 41.69126 ? 60   GLU   B C   1 
ATOM   4088 O O   . GLU   B 1 78  ? -6.38345  6.17686   -54.22057 1.000 47.43261 ? 60   GLU   B O   1 
ATOM   4089 C CB  . GLU   B 1 78  ? -8.40802  5.11768   -52.17051 1.000 41.58959 ? 60   GLU   B CB  1 
ATOM   4090 C CG  . GLU   B 1 78  ? -8.30693  3.76539   -52.88604 1.000 47.96159 ? 60   GLU   B CG  1 
ATOM   4091 C CD  . GLU   B 1 78  ? -9.62085  2.98981   -52.88430 1.000 49.02643 ? 60   GLU   B CD  1 
ATOM   4092 O OE1 . GLU   B 1 78  ? -10.44471 3.19630   -53.80268 1.000 54.92525 ? 60   GLU   B OE1 1 
ATOM   4093 O OE2 . GLU   B 1 78  ? -9.82278  2.15617   -51.97526 1.000 56.48889 ? 60   GLU   B OE2 1 
ATOM   4094 N N   . LEU   B 1 79  ? -5.08691  4.83884   -52.94472 1.000 36.39735 ? 61   LEU   B N   1 
ATOM   4095 C CA  . LEU   B 1 79  ? -4.07505  4.63819   -53.97873 1.000 35.69510 ? 61   LEU   B CA  1 
ATOM   4096 C C   . LEU   B 1 79  ? -4.67613  3.88543   -55.15937 1.000 45.52846 ? 61   LEU   B C   1 
ATOM   4097 O O   . LEU   B 1 79  ? -4.97018  2.68828   -55.06325 1.000 38.39320 ? 61   LEU   B O   1 
ATOM   4098 C CB  . LEU   B 1 79  ? -2.87142  3.88681   -53.41807 1.000 34.94980 ? 61   LEU   B CB  1 
ATOM   4099 C CG  . LEU   B 1 79  ? -1.69814  3.77129   -54.40158 1.000 43.13826 ? 61   LEU   B CG  1 
ATOM   4100 C CD1 . LEU   B 1 79  ? -1.36963  5.12411   -55.04692 1.000 39.48083 ? 61   LEU   B CD1 1 
ATOM   4101 C CD2 . LEU   B 1 79  ? -0.46971  3.16559   -53.73469 1.000 33.02874 ? 61   LEU   B CD2 1 
ATOM   4102 N N   . THR   B 1 80  ? -4.84587  4.59222   -56.27528 1.000 37.17013 ? 62   THR   B N   1 
ATOM   4103 C CA  . THR   B 1 80  ? -5.29673  4.02048   -57.53500 1.000 43.48176 ? 62   THR   B CA  1 
ATOM   4104 C C   . THR   B 1 80  ? -4.48046  4.63716   -58.66578 1.000 50.69342 ? 62   THR   B C   1 
ATOM   4105 O O   . THR   B 1 80  ? -3.70549  5.58000   -58.46214 1.000 38.70040 ? 62   THR   B O   1 
ATOM   4106 C CB  . THR   B 1 80  ? -6.80101  4.24967   -57.75187 1.000 42.24010 ? 62   THR   B CB  1 
ATOM   4107 O OG1 . THR   B 1 80  ? -7.30789  3.28278   -58.68409 1.000 48.24517 ? 62   THR   B OG1 1 
ATOM   4108 C CG2 . THR   B 1 80  ? -7.06222  5.65541   -58.27754 1.000 42.20829 ? 62   THR   B CG2 1 
ATOM   4109 N N   . PHE   B 1 81  ? -4.64968  4.08672   -59.86793 1.000 44.04425 ? 63   PHE   B N   1 
ATOM   4110 C CA  . PHE   B 1 81  ? -3.96979  4.58691   -61.05359 1.000 34.39779 ? 63   PHE   B CA  1 
ATOM   4111 C C   . PHE   B 1 81  ? -4.95607  4.68895   -62.20941 1.000 44.91551 ? 63   PHE   B C   1 
ATOM   4112 O O   . PHE   B 1 81  ? -5.99808  4.02333   -62.22710 1.000 41.68573 ? 63   PHE   B O   1 
ATOM   4113 C CB  . PHE   B 1 81  ? -2.78028  3.69421   -61.44439 1.000 27.82174 ? 63   PHE   B CB  1 
ATOM   4114 C CG  . PHE   B 1 81  ? -1.73263  3.57479   -60.36727 1.000 33.76876 ? 63   PHE   B CG  1 
ATOM   4115 C CD1 . PHE   B 1 81  ? -1.84047  2.61001   -59.37198 1.000 30.95165 ? 63   PHE   B CD1 1 
ATOM   4116 C CD2 . PHE   B 1 81  ? -0.64814  4.44693   -60.33707 1.000 36.39609 ? 63   PHE   B CD2 1 
ATOM   4117 C CE1 . PHE   B 1 81  ? -0.87437  2.50465   -58.37183 1.000 28.64612 ? 63   PHE   B CE1 1 
ATOM   4118 C CE2 . PHE   B 1 81  ? 0.31612   4.35020   -59.34535 1.000 29.81679 ? 63   PHE   B CE2 1 
ATOM   4119 C CZ  . PHE   B 1 81  ? 0.20209   3.37472   -58.36094 1.000 36.22641 ? 63   PHE   B CZ  1 
ATOM   4120 N N   . GLN   B 1 82  ? -4.60746  5.54265   -63.18119 1.000 30.21236 ? 64   GLN   B N   1 
ATOM   4121 C CA  . GLN   B 1 82  ? -5.40952  5.78079   -64.37681 1.000 37.14936 ? 64   GLN   B CA  1 
ATOM   4122 C C   . GLN   B 1 82  ? -4.55036  6.52419   -65.39590 1.000 40.88744 ? 64   GLN   B C   1 
ATOM   4123 O O   . GLN   B 1 82  ? -3.58329  7.19663   -65.01004 1.000 37.41856 ? 64   GLN   B O   1 
ATOM   4124 C CB  . GLN   B 1 82  ? -6.68051  6.57179   -64.05207 1.000 36.69516 ? 64   GLN   B CB  1 
ATOM   4125 C CG  . GLN   B 1 82  ? -6.45198  7.98112   -63.53309 1.000 35.03222 ? 64   GLN   B CG  1 
ATOM   4126 C CD  . GLN   B 1 82  ? -5.82544  8.00903   -62.15482 1.000 46.63385 ? 64   GLN   B CD  1 
ATOM   4127 O OE1 . GLN   B 1 82  ? -6.25664  7.29427   -61.24577 1.000 39.71354 ? 64   GLN   B OE1 1 
ATOM   4128 N NE2 . GLN   B 1 82  ? -4.78913  8.82673   -61.99501 1.000 36.94122 ? 64   GLN   B NE2 1 
ATOM   4129 N N   . PRO   B 1 83  ? -4.85881  6.42167   -66.69800 1.000 40.78608 ? 65   PRO   B N   1 
ATOM   4130 C CA  . PRO   B 1 83  ? -3.99028  7.04758   -67.71809 1.000 27.76205 ? 65   PRO   B CA  1 
ATOM   4131 C C   . PRO   B 1 83  ? -3.71344  8.53540   -67.52019 1.000 38.38089 ? 65   PRO   B C   1 
ATOM   4132 O O   . PRO   B 1 83  ? -2.58960  8.97808   -67.78751 1.000 34.55532 ? 65   PRO   B O   1 
ATOM   4133 C CB  . PRO   B 1 83  ? -4.76383  6.77763   -69.01663 1.000 33.61302 ? 65   PRO   B CB  1 
ATOM   4134 C CG  . PRO   B 1 83  ? -5.43310  5.46372   -68.75909 1.000 31.18937 ? 65   PRO   B CG  1 
ATOM   4135 C CD  . PRO   B 1 83  ? -5.86708  5.53480   -67.31186 1.000 36.63822 ? 65   PRO   B CD  1 
ATOM   4136 N N   . SER   B 1 84  ? -4.68942  9.32021   -67.05552 1.000 44.79652 ? 66   SER   B N   1 
ATOM   4137 C CA  . SER   B 1 84  ? -4.50304  10.76524  -66.92600 1.000 29.53135 ? 66   SER   B CA  1 
ATOM   4138 C C   . SER   B 1 84  ? -3.98794  11.08713  -65.52118 1.000 30.05581 ? 66   SER   B C   1 
ATOM   4139 O O   . SER   B 1 84  ? -3.79339  10.15983  -64.71986 1.000 34.17102 ? 66   SER   B O   1 
ATOM   4140 C CB  . SER   B 1 84  ? -5.82032  11.48693  -67.24933 1.000 33.60075 ? 66   SER   B CB  1 
ATOM   4141 O OG  . SER   B 1 84  ? -6.71349  11.48399  -66.14728 1.000 43.98714 ? 66   SER   B OG  1 
ATOM   4142 N N   . PRO   B 1 85  ? -3.70895  12.35566  -65.18650 1.000 25.93036 ? 67   PRO   B N   1 
ATOM   4143 C CA  . PRO   B 1 85  ? -3.35744  12.67782  -63.79559 1.000 20.79260 ? 67   PRO   B CA  1 
ATOM   4144 C C   . PRO   B 1 85  ? -4.51513  12.38911  -62.85026 1.000 21.49848 ? 67   PRO   B C   1 
ATOM   4145 O O   . PRO   B 1 85  ? -5.68684  12.50495  -63.21903 1.000 16.98330 ? 67   PRO   B O   1 
ATOM   4146 C CB  . PRO   B 1 85  ? -3.04740  14.18064  -63.84322 1.000 18.31188 ? 67   PRO   B CB  1 
ATOM   4147 C CG  . PRO   B 1 85  ? -2.68865  14.45441  -65.27270 1.000 17.68382 ? 67   PRO   B CG  1 
ATOM   4148 C CD  . PRO   B 1 85  ? -3.54632  13.52736  -66.07329 1.000 16.16150 ? 67   PRO   B CD  1 
ATOM   4149 N N   . ALA   B 1 86  ? -4.17436  12.00595  -61.61750 1.000 18.26850 ? 68   ALA   B N   1 
ATOM   4150 C CA  . ALA   B 1 86  ? -5.19036  11.86204  -60.58590 1.000 20.47801 ? 68   ALA   B CA  1 
ATOM   4151 C C   . ALA   B 1 86  ? -5.87308  13.20950  -60.33382 1.000 20.75455 ? 68   ALA   B C   1 
ATOM   4152 O O   . ALA   B 1 86  ? -5.23763  14.26670  -60.43506 1.000 21.52134 ? 68   ALA   B O   1 
ATOM   4153 C CB  . ALA   B 1 86  ? -4.57558  11.32613  -59.29232 1.000 21.46971 ? 68   ALA   B CB  1 
ATOM   4154 N N   . PRO   B 1 87  ? -7.17285  13.19875  -60.01604 1.000 20.38916 ? 69   PRO   B N   1 
ATOM   4155 C CA  . PRO   B 1 87  ? -7.90296  14.46864  -59.84553 1.000 26.28264 ? 69   PRO   B CA  1 
ATOM   4156 C C   . PRO   B 1 87  ? -7.44749  15.28954  -58.64755 1.000 25.49991 ? 69   PRO   B C   1 
ATOM   4157 O O   . PRO   B 1 87  ? -7.49550  16.52323  -58.70335 1.000 22.45015 ? 69   PRO   B O   1 
ATOM   4158 C CB  . PRO   B 1 87  ? -9.36167  14.01183  -59.69019 1.000 22.99974 ? 69   PRO   B CB  1 
ATOM   4159 C CG  . PRO   B 1 87  ? -9.27641  12.58505  -59.26678 1.000 28.81446 ? 69   PRO   B CG  1 
ATOM   4160 C CD  . PRO   B 1 87  ? -8.06982  12.03317  -59.94638 1.000 30.70349 ? 69   PRO   B CD  1 
ATOM   4161 N N   . ASP   B 1 88  ? -7.02548  14.64838  -57.56526 1.000 28.04918 ? 70   ASP   B N   1 
ATOM   4162 C CA  . ASP   B 1 88  ? -6.45021  15.30025  -56.39862 1.000 25.14778 ? 70   ASP   B CA  1 
ATOM   4163 C C   . ASP   B 1 88  ? -5.02656  14.79014  -56.19315 1.000 23.38970 ? 70   ASP   B C   1 
ATOM   4164 O O   . ASP   B 1 88  ? -4.69974  13.68142  -56.63352 1.000 23.20568 ? 70   ASP   B O   1 
ATOM   4165 C CB  . ASP   B 1 88  ? -7.28764  15.02346  -55.13779 1.000 23.71751 ? 70   ASP   B CB  1 
ATOM   4166 C CG  . ASP   B 1 88  ? -8.78039  15.26434  -55.35441 1.000 31.91918 ? 70   ASP   B CG  1 
ATOM   4167 O OD1 . ASP   B 1 88  ? -9.17961  16.43225  -55.54697 1.000 27.33886 ? 70   ASP   B OD1 1 
ATOM   4168 O OD2 . ASP   B 1 88  ? -9.55832  14.28304  -55.33065 1.000 34.94140 ? 70   ASP   B OD2 1 
ATOM   4169 N N   . PRO   B 1 89  ? -4.15471  15.56786  -55.55147 1.000 20.69142 ? 71   PRO   B N   1 
ATOM   4170 C CA  . PRO   B 1 89  ? -2.77872  15.10612  -55.32025 1.000 16.87772 ? 71   PRO   B CA  1 
ATOM   4171 C C   . PRO   B 1 89  ? -2.76565  13.73179  -54.67214 1.000 23.36884 ? 71   PRO   B C   1 
ATOM   4172 O O   . PRO   B 1 89  ? -3.24947  13.55491  -53.54268 1.000 19.43136 ? 71   PRO   B O   1 
ATOM   4173 C CB  . PRO   B 1 89  ? -2.20135  16.17955  -54.38555 1.000 25.16823 ? 71   PRO   B CB  1 
ATOM   4174 C CG  . PRO   B 1 89  ? -2.97891  17.40133  -54.72858 1.000 19.76112 ? 71   PRO   B CG  1 
ATOM   4175 C CD  . PRO   B 1 89  ? -4.37006  16.93521  -55.03446 1.000 20.32630 ? 71   PRO   B CD  1 
ATOM   4176 N N   . PRO   B 1 90  ? -2.23307  12.72224  -55.36805 1.000 22.79154 ? 72   PRO   B N   1 
ATOM   4177 C CA  . PRO   B 1 90  ? -2.43192  11.33007  -54.92352 1.000 23.03507 ? 72   PRO   B CA  1 
ATOM   4178 C C   . PRO   B 1 90  ? -1.67085  10.96660  -53.65841 1.000 35.66140 ? 72   PRO   B C   1 
ATOM   4179 O O   . PRO   B 1 90  ? -1.97330  9.92878   -53.05470 1.000 22.88410 ? 72   PRO   B O   1 
ATOM   4180 C CB  . PRO   B 1 90  ? -1.95045  10.49043  -56.11783 1.000 19.53582 ? 72   PRO   B CB  1 
ATOM   4181 C CG  . PRO   B 1 90  ? -1.20439  11.41723  -57.02455 1.000 22.49306 ? 72   PRO   B CG  1 
ATOM   4182 C CD  . PRO   B 1 90  ? -1.44544  12.83923  -56.60812 1.000 22.18842 ? 72   PRO   B CD  1 
ATOM   4183 N N   . GLY   B 1 91  ? -0.69980  11.77310  -53.23686 1.000 23.61239 ? 73   GLY   B N   1 
ATOM   4184 C CA  . GLY   B 1 91  ? -0.04048  11.56986  -51.96496 1.000 22.01108 ? 73   GLY   B CA  1 
ATOM   4185 C C   . GLY   B 1 91  ? -0.40128  12.57262  -50.89649 1.000 19.97870 ? 73   GLY   B C   1 
ATOM   4186 O O   . GLY   B 1 91  ? 0.28001   12.62204  -49.86408 1.000 25.55109 ? 73   GLY   B O   1 
ATOM   4187 N N   . GLY   B 1 92  ? -1.44292  13.37334  -51.09366 1.000 21.42830 ? 74   GLY   B N   1 
ATOM   4188 C CA  . GLY   B 1 92  ? -1.75336  14.44664  -50.17772 1.000 23.98740 ? 74   GLY   B CA  1 
ATOM   4189 C C   . GLY   B 1 92  ? -0.87377  15.66108  -50.41526 1.000 31.85033 ? 74   GLY   B C   1 
ATOM   4190 O O   . GLY   B 1 92  ? -0.06365  15.72080  -51.34402 1.000 25.62101 ? 74   GLY   B O   1 
ATOM   4191 N N   . LEU   B 1 93  ? -1.04238  16.65024  -49.53673 1.000 27.39062 ? 75   LEU   B N   1 
ATOM   4192 C CA  . LEU   B 1 93  ? -0.34838  17.92895  -49.61751 1.000 24.21437 ? 75   LEU   B CA  1 
ATOM   4193 C C   . LEU   B 1 93  ? 0.26896   18.24593  -48.26276 1.000 24.70639 ? 75   LEU   B C   1 
ATOM   4194 O O   . LEU   B 1 93  ? -0.29044  17.88839  -47.22626 1.000 23.96868 ? 75   LEU   B O   1 
ATOM   4195 C CB  . LEU   B 1 93  ? -1.32136  19.06443  -49.97748 1.000 24.22559 ? 75   LEU   B CB  1 
ATOM   4196 C CG  . LEU   B 1 93  ? -1.96490  19.18020  -51.35571 1.000 38.30271 ? 75   LEU   B CG  1 
ATOM   4197 C CD1 . LEU   B 1 93  ? -2.75373  20.48104  -51.44226 1.000 23.02580 ? 75   LEU   B CD1 1 
ATOM   4198 C CD2 . LEU   B 1 93  ? -0.91798  19.12518  -52.44728 1.000 33.79696 ? 75   LEU   B CD2 1 
ATOM   4199 N N   . THR   B 1 94  ? 1.42152   18.91759  -48.27170 1.000 16.29758 ? 76   THR   B N   1 
ATOM   4200 C CA  . THR   B 1 94  ? 1.88506   19.67910  -47.12048 1.000 17.68646 ? 76   THR   B CA  1 
ATOM   4201 C C   . THR   B 1 94  ? 1.75694   21.14984  -47.47178 1.000 20.48835 ? 76   THR   B C   1 
ATOM   4202 O O   . THR   B 1 94  ? 1.85724   21.51955  -48.64316 1.000 22.15548 ? 76   THR   B O   1 
ATOM   4203 C CB  . THR   B 1 94  ? 3.34239   19.37855  -46.74436 1.000 26.93272 ? 76   THR   B CB  1 
ATOM   4204 O OG1 . THR   B 1 94  ? 4.19858   19.62565  -47.86811 1.000 25.94962 ? 76   THR   B OG1 1 
ATOM   4205 C CG2 . THR   B 1 94  ? 3.49893   17.93621  -46.28189 1.000 20.87895 ? 76   THR   B CG2 1 
ATOM   4206 N N   . TYR   B 1 95  ? 1.52778   21.99549  -46.46896 1.000 18.45323 ? 77   TYR   B N   1 
ATOM   4207 C CA  . TYR   B 1 95  ? 1.38320   23.41560  -46.75340 1.000 24.01238 ? 77   TYR   B CA  1 
ATOM   4208 C C   . TYR   B 1 95  ? 2.07224   24.26233  -45.68807 1.000 20.50052 ? 77   TYR   B C   1 
ATOM   4209 O O   . TYR   B 1 95  ? 2.55813   23.76823  -44.66823 1.000 19.88637 ? 77   TYR   B O   1 
ATOM   4210 C CB  . TYR   B 1 95  ? -0.09561  23.81532  -46.91601 1.000 16.35788 ? 77   TYR   B CB  1 
ATOM   4211 C CG  . TYR   B 1 95  ? -0.94409  23.81876  -45.65640 1.000 19.77275 ? 77   TYR   B CG  1 
ATOM   4212 C CD1 . TYR   B 1 95  ? -1.04832  24.96039  -44.86673 1.000 17.86412 ? 77   TYR   B CD1 1 
ATOM   4213 C CD2 . TYR   B 1 95  ? -1.66462  22.69504  -45.27820 1.000 24.45074 ? 77   TYR   B CD2 1 
ATOM   4214 C CE1 . TYR   B 1 95  ? -1.83782  24.97707  -43.72261 1.000 19.22036 ? 77   TYR   B CE1 1 
ATOM   4215 C CE2 . TYR   B 1 95  ? -2.45902  22.69918  -44.13539 1.000 26.51504 ? 77   TYR   B CE2 1 
ATOM   4216 C CZ  . TYR   B 1 95  ? -2.53964  23.84193  -43.36024 1.000 24.88658 ? 77   TYR   B CZ  1 
ATOM   4217 O OH  . TYR   B 1 95  ? -3.32107  23.85388  -42.22321 1.000 19.25838 ? 77   TYR   B OH  1 
ATOM   4218 N N   . PHE   B 1 96  ? 2.12395   25.56576  -45.95643 1.000 20.20869 ? 78   PHE   B N   1 
ATOM   4219 C CA  . PHE   B 1 96  ? 2.74169   26.49789  -45.05621 1.000 18.38970 ? 78   PHE   B CA  1 
ATOM   4220 C C   . PHE   B 1 96  ? 1.90158   27.76893  -45.03118 1.000 18.45413 ? 78   PHE   B C   1 
ATOM   4221 O O   . PHE   B 1 96  ? 1.61825   28.34242  -46.10180 1.000 16.84776 ? 78   PHE   B O   1 
ATOM   4222 C CB  . PHE   B 1 96  ? 4.18116   26.81140  -45.47084 1.000 13.68764 ? 78   PHE   B CB  1 
ATOM   4223 C CG  . PHE   B 1 96  ? 4.93066   27.60837  -44.44296 1.000 16.02724 ? 78   PHE   B CG  1 
ATOM   4224 C CD1 . PHE   B 1 96  ? 4.85480   28.99291  -44.43579 1.000 15.19994 ? 78   PHE   B CD1 1 
ATOM   4225 C CD2 . PHE   B 1 96  ? 5.67313   26.96789  -43.45670 1.000 16.61306 ? 78   PHE   B CD2 1 
ATOM   4226 C CE1 . PHE   B 1 96  ? 5.51864   29.73475  -43.48038 1.000 13.76120 ? 78   PHE   B CE1 1 
ATOM   4227 C CE2 . PHE   B 1 96  ? 6.34185   27.70190  -42.49443 1.000 13.42738 ? 78   PHE   B CE2 1 
ATOM   4228 C CZ  . PHE   B 1 96  ? 6.25071   29.09749  -42.50688 1.000 12.54394 ? 78   PHE   B CZ  1 
ATOM   4229 N N   . PRO   B 1 97  ? 1.50247   28.24888  -43.84308 1.000 13.42881 ? 79   PRO   B N   1 
ATOM   4230 C CA  . PRO   B 1 97  ? 0.79075   29.53205  -43.74681 1.000 18.16300 ? 79   PRO   B CA  1 
ATOM   4231 C C   . PRO   B 1 97  ? 1.77698   30.68829  -43.81376 1.000 20.45698 ? 79   PRO   B C   1 
ATOM   4232 O O   . PRO   B 1 97  ? 2.59401   30.88374  -42.90787 1.000 14.20344 ? 79   PRO   B O   1 
ATOM   4233 C CB  . PRO   B 1 97  ? 0.10114   29.44283  -42.37742 1.000 16.72255 ? 79   PRO   B CB  1 
ATOM   4234 C CG  . PRO   B 1 97  ? 1.05339   28.60105  -41.55033 1.000 18.14803 ? 79   PRO   B CG  1 
ATOM   4235 C CD  . PRO   B 1 97  ? 1.76224   27.65597  -42.51629 1.000 15.40775 ? 79   PRO   B CD  1 
ATOM   4236 N N   . VAL   B 1 98  ? 1.70734   31.45698  -44.90287 1.000 13.43952 ? 80   VAL   B N   1 
ATOM   4237 C CA  . VAL   B 1 98  ? 2.67745   32.51991  -45.12512 1.000 13.83397 ? 80   VAL   B CA  1 
ATOM   4238 C C   . VAL   B 1 98  ? 2.59441   33.50472  -43.98048 1.000 13.35868 ? 80   VAL   B C   1 
ATOM   4239 O O   . VAL   B 1 98  ? 1.49971   33.91949  -43.57741 1.000 18.65230 ? 80   VAL   B O   1 
ATOM   4240 C CB  . VAL   B 1 98  ? 2.42733   33.20121  -46.47861 1.000 15.13898 ? 80   VAL   B CB  1 
ATOM   4241 C CG1 . VAL   B 1 98  ? 3.23297   34.52386  -46.58128 1.000 14.25365 ? 80   VAL   B CG1 1 
ATOM   4242 C CG2 . VAL   B 1 98  ? 2.78444   32.24326  -47.60676 1.000 16.82266 ? 80   VAL   B CG2 1 
ATOM   4243 N N   . ALA   B 1 99  ? 3.74958   33.85035  -43.41863 1.000 12.73413 ? 81   ALA   B N   1 
ATOM   4244 C CA  . ALA   B 1 99  ? 3.83012   34.78047  -42.29716 1.000 13.98779 ? 81   ALA   B CA  1 
ATOM   4245 C C   . ALA   B 1 99  ? 4.34781   36.12420  -42.81296 1.000 19.02706 ? 81   ALA   B C   1 
ATOM   4246 O O   . ALA   B 1 99  ? 5.54965   36.29272  -43.05304 1.000 16.67804 ? 81   ALA   B O   1 
ATOM   4247 C CB  . ALA   B 1 99  ? 4.71430   34.21583  -41.18816 1.000 14.12527 ? 81   ALA   B CB  1 
ATOM   4248 N N   . ASP   B 1 100 ? 3.43490   37.07789  -42.97841 1.000 17.94411 ? 82   ASP   B N   1 
ATOM   4249 C CA  . ASP   B 1 100 ? 3.79064   38.39979  -43.47047 1.000 20.26470 ? 82   ASP   B CA  1 
ATOM   4250 C C   . ASP   B 1 100 ? 4.35142   39.25641  -42.34783 1.000 19.22513 ? 82   ASP   B C   1 
ATOM   4251 O O   . ASP   B 1 100 ? 3.99317   39.09562  -41.17821 1.000 19.23664 ? 82   ASP   B O   1 
ATOM   4252 C CB  . ASP   B 1 100 ? 2.57289   39.10294  -44.07665 1.000 21.40213 ? 82   ASP   B CB  1 
ATOM   4253 C CG  . ASP   B 1 100 ? 2.07764   38.42461  -45.32204 1.000 30.65711 ? 82   ASP   B CG  1 
ATOM   4254 O OD1 . ASP   B 1 100 ? 2.85316   38.34720  -46.29919 1.000 30.96513 ? 82   ASP   B OD1 1 
ATOM   4255 O OD2 . ASP   B 1 100 ? 0.92112   37.96351  -45.32221 1.000 36.49301 ? 82   ASP   B OD2 1 
ATOM   4256 N N   . LEU   B 1 101 ? 5.22271   40.19514  -42.72398 1.000 20.74727 ? 83   LEU   B N   1 
ATOM   4257 C CA  . LEU   B 1 101 ? 5.75417   41.14006  -41.75046 1.000 22.01662 ? 83   LEU   B CA  1 
ATOM   4258 C C   . LEU   B 1 101 ? 4.63748   41.88964  -41.04579 1.000 25.65345 ? 83   LEU   B C   1 
ATOM   4259 O O   . LEU   B 1 101 ? 4.67041   42.06155  -39.82259 1.000 24.12264 ? 83   LEU   B O   1 
ATOM   4260 C CB  . LEU   B 1 101 ? 6.70054   42.12431  -42.43156 1.000 25.47948 ? 83   LEU   B CB  1 
ATOM   4261 C CG  . LEU   B 1 101 ? 7.31062   43.08450  -41.41454 1.000 39.38720 ? 83   LEU   B CG  1 
ATOM   4262 C CD1 . LEU   B 1 101 ? 8.15163   42.28801  -40.42499 1.000 26.94656 ? 83   LEU   B CD1 1 
ATOM   4263 C CD2 . LEU   B 1 101 ? 8.13263   44.17178  -42.09723 1.000 35.55114 ? 83   LEU   B CD2 1 
ATOM   4264 N N   . SER   B 1 102 ? 3.62801   42.32614  -41.79999 1.000 21.60117 ? 84   SER   B N   1 
ATOM   4265 C CA  . SER   B 1 102 ? 2.54829   43.11302  -41.21720 1.000 26.84268 ? 84   SER   B CA  1 
ATOM   4266 C C   . SER   B 1 102 ? 1.84051   42.35192  -40.10220 1.000 30.62322 ? 84   SER   B C   1 
ATOM   4267 O O   . SER   B 1 102 ? 1.58098   42.90188  -39.02516 1.000 28.79164 ? 84   SER   B O   1 
ATOM   4268 C CB  . SER   B 1 102 ? 1.56474   43.51594  -42.31400 1.000 25.26101 ? 84   SER   B CB  1 
ATOM   4269 O OG  . SER   B 1 102 ? 0.85787   42.38514  -42.78672 1.000 25.50774 ? 84   SER   B OG  1 
ATOM   4270 N N   . ILE   B 1 103 ? 1.51890   41.08179  -40.34133 1.000 21.32587 ? 85   ILE   B N   1 
ATOM   4271 C CA  . ILE   B 1 103 ? 0.80440   40.29858  -39.33834 1.000 23.17867 ? 85   ILE   B CA  1 
ATOM   4272 C C   . ILE   B 1 103 ? 1.68042   40.08771  -38.10997 1.000 19.09613 ? 85   ILE   B C   1 
ATOM   4273 O O   . ILE   B 1 103 ? 1.26008   40.34718  -36.97499 1.000 15.85658 ? 85   ILE   B O   1 
ATOM   4274 C CB  . ILE   B 1 103 ? 0.34236   38.95567  -39.93778 1.000 19.90310 ? 85   ILE   B CB  1 
ATOM   4275 C CG1 . ILE   B 1 103 ? -0.69214  39.17793  -41.04634 1.000 30.71875 ? 85   ILE   B CG1 1 
ATOM   4276 C CG2 . ILE   B 1 103 ? -0.19912  38.03235  -38.85158 1.000 26.24323 ? 85   ILE   B CG2 1 
ATOM   4277 C CD1 . ILE   B 1 103 ? -1.91258  39.96764  -40.61332 1.000 27.24948 ? 85   ILE   B CD1 1 
ATOM   4278 N N   . ILE   B 1 104 ? 2.91016   39.60715  -38.32025 1.000 19.39602 ? 86   ILE   B N   1 
ATOM   4279 C CA  . ILE   B 1 104 ? 3.81066   39.32033  -37.20312 1.000 19.57039 ? 86   ILE   B CA  1 
ATOM   4280 C C   . ILE   B 1 104 ? 4.19139   40.60176  -36.46718 1.000 18.89309 ? 86   ILE   B C   1 
ATOM   4281 O O   . ILE   B 1 104 ? 4.21316   40.63849  -35.23132 1.000 17.53912 ? 86   ILE   B O   1 
ATOM   4282 C CB  . ILE   B 1 104 ? 5.05675   38.55592  -37.69738 1.000 17.77941 ? 86   ILE   B CB  1 
ATOM   4283 C CG1 . ILE   B 1 104 ? 4.65710   37.20529  -38.30355 1.000 20.46997 ? 86   ILE   B CG1 1 
ATOM   4284 C CG2 . ILE   B 1 104 ? 6.05980   38.34646  -36.56215 1.000 16.67290 ? 86   ILE   B CG2 1 
ATOM   4285 C CD1 . ILE   B 1 104 ? 3.93664   36.28117  -37.33506 1.000 20.60630 ? 86   ILE   B CD1 1 
ATOM   4286 N N   . ALA   B 1 105 ? 4.51667   41.66673  -37.20610 1.000 17.23643 ? 87   ALA   B N   1 
ATOM   4287 C CA  . ALA   B 1 105 ? 4.92843   42.90597  -36.54933 1.000 20.19044 ? 87   ALA   B CA  1 
ATOM   4288 C C   . ALA   B 1 105 ? 3.79157   43.52714  -35.74806 1.000 16.12636 ? 87   ALA   B C   1 
ATOM   4289 O O   . ALA   B 1 105 ? 4.03924   44.13231  -34.70235 1.000 17.95544 ? 87   ALA   B O   1 
ATOM   4290 C CB  . ALA   B 1 105 ? 5.46730   43.91107  -37.56958 1.000 17.34879 ? 87   ALA   B CB  1 
ATOM   4291 N N   . ALA   B 1 106 ? 2.54423   43.38363  -36.20453 1.000 15.77102 ? 88   ALA   B N   1 
ATOM   4292 C CA  . ALA   B 1 106 ? 1.41673   43.91028  -35.43478 1.000 19.95585 ? 88   ALA   B CA  1 
ATOM   4293 C C   . ALA   B 1 106 ? 1.26393   43.18607  -34.10072 1.000 20.90455 ? 88   ALA   B C   1 
ATOM   4294 O O   . ALA   B 1 106 ? 1.00604   43.81747  -33.06929 1.000 17.83538 ? 88   ALA   B O   1 
ATOM   4295 C CB  . ALA   B 1 106 ? 0.12439   43.80797  -36.24755 1.000 21.11526 ? 88   ALA   B CB  1 
ATOM   4296 N N   . LEU   B 1 107 ? 1.41160   41.85762  -34.10351 1.000 18.56904 ? 89   LEU   B N   1 
ATOM   4297 C CA  . LEU   B 1 107 ? 1.29254   41.08743  -32.86649 1.000 14.45231 ? 89   LEU   B CA  1 
ATOM   4298 C C   . LEU   B 1 107 ? 2.47055   41.35764  -31.94002 1.000 14.58337 ? 89   LEU   B C   1 
ATOM   4299 O O   . LEU   B 1 107 ? 2.30276   41.46334  -30.72136 1.000 15.37880 ? 89   LEU   B O   1 
ATOM   4300 C CB  . LEU   B 1 107 ? 1.19597   39.59571  -33.19540 1.000 15.41886 ? 89   LEU   B CB  1 
ATOM   4301 C CG  . LEU   B 1 107 ? -0.07097  39.19061  -33.95518 1.000 23.58072 ? 89   LEU   B CG  1 
ATOM   4302 C CD1 . LEU   B 1 107 ? 0.02599   37.78325  -34.49082 1.000 20.69861 ? 89   LEU   B CD1 1 
ATOM   4303 C CD2 . LEU   B 1 107 ? -1.30653  39.34265  -33.07379 1.000 22.05292 ? 89   LEU   B CD2 1 
ATOM   4304 N N   . TYR   B 1 108 ? 3.66829   41.46633  -32.50818 1.000 12.68156 ? 90   TYR   B N   1 
ATOM   4305 C CA  . TYR   B 1 108 ? 4.85025   41.84729  -31.74095 1.000 12.77020 ? 90   TYR   B CA  1 
ATOM   4306 C C   . TYR   B 1 108 ? 4.65898   43.20706  -31.07663 1.000 19.24197 ? 90   TYR   B C   1 
ATOM   4307 O O   . TYR   B 1 108 ? 4.94865   43.38175  -29.88377 1.000 12.12960 ? 90   TYR   B O   1 
ATOM   4308 C CB  . TYR   B 1 108 ? 6.05323   41.85495  -32.67602 1.000 9.24643  ? 90   TYR   B CB  1 
ATOM   4309 C CG  . TYR   B 1 108 ? 7.39992   42.11204  -32.03869 1.000 16.63839 ? 90   TYR   B CG  1 
ATOM   4310 C CD1 . TYR   B 1 108 ? 7.86711   43.41095  -31.84582 1.000 13.82234 ? 90   TYR   B CD1 1 
ATOM   4311 C CD2 . TYR   B 1 108 ? 8.23375   41.05288  -31.68677 1.000 14.96380 ? 90   TYR   B CD2 1 
ATOM   4312 C CE1 . TYR   B 1 108 ? 9.12033   43.64771  -31.28059 1.000 15.76980 ? 90   TYR   B CE1 1 
ATOM   4313 C CE2 . TYR   B 1 108 ? 9.48014   41.28038  -31.12233 1.000 19.95436 ? 90   TYR   B CE2 1 
ATOM   4314 C CZ  . TYR   B 1 108 ? 9.91590   42.57685  -30.92006 1.000 18.91028 ? 90   TYR   B CZ  1 
ATOM   4315 O OH  . TYR   B 1 108 ? 11.15508  42.78862  -30.36259 1.000 17.15904 ? 90   TYR   B OH  1 
ATOM   4316 N N   . ALA   B 1 109 ? 4.16840   44.18707  -31.84069 1.000 18.98382 ? 91   ALA   B N   1 
ATOM   4317 C CA  . ALA   B 1 109 ? 3.91403   45.51386  -31.28166 1.000 21.62743 ? 91   ALA   B CA  1 
ATOM   4318 C C   . ALA   B 1 109 ? 2.88327   45.46314  -30.16144 1.000 17.91424 ? 91   ALA   B C   1 
ATOM   4319 O O   . ALA   B 1 109 ? 3.04090   46.14388  -29.14128 1.000 20.29106 ? 91   ALA   B O   1 
ATOM   4320 C CB  . ALA   B 1 109 ? 3.46299   46.47309  -32.38400 1.000 16.09603 ? 91   ALA   B CB  1 
ATOM   4321 N N   . ARG   B 1 110 ? 1.81914   44.66746  -30.33384 1.000 17.63139 ? 92   ARG   B N   1 
ATOM   4322 C CA  . ARG   B 1 110 ? 0.81806   44.49121  -29.27982 1.000 18.49761 ? 92   ARG   B CA  1 
ATOM   4323 C C   . ARG   B 1 110 ? 1.44933   44.02396  -27.97317 1.000 18.24787 ? 92   ARG   B C   1 
ATOM   4324 O O   . ARG   B 1 110 ? 1.20909   44.60707  -26.90991 1.000 19.43107 ? 92   ARG   B O   1 
ATOM   4325 C CB  . ARG   B 1 110 ? -0.24574  43.48180  -29.72047 1.000 22.31790 ? 92   ARG   B CB  1 
ATOM   4326 C CG  . ARG   B 1 110 ? -1.45043  44.06852  -30.40008 1.000 28.87112 ? 92   ARG   B CG  1 
ATOM   4327 C CD  . ARG   B 1 110 ? -2.34279  42.99032  -30.99179 1.000 28.50174 ? 92   ARG   B CD  1 
ATOM   4328 N NE  . ARG   B 1 110 ? -3.13180  42.29636  -29.98216 1.000 25.25970 ? 92   ARG   B NE  1 
ATOM   4329 C CZ  . ARG   B 1 110 ? -3.99078  41.32481  -30.25926 1.000 28.62718 ? 92   ARG   B CZ  1 
ATOM   4330 N NH1 . ARG   B 1 110 ? -4.19365  40.91934  -31.50040 1.000 35.08393 ? 92   ARG   B NH1 1 
ATOM   4331 N NH2 . ARG   B 1 110 ? -4.66625  40.74920  -29.26783 1.000 35.21027 ? 92   ARG   B NH2 1 
ATOM   4332 N N   . PHE   B 1 111 ? 2.23486   42.94505  -28.03284 1.000 15.40570 ? 93   PHE   B N   1 
ATOM   4333 C CA  . PHE   B 1 111 ? 2.87813   42.42190  -26.83070 1.000 16.27424 ? 93   PHE   B CA  1 
ATOM   4334 C C   . PHE   B 1 111 ? 3.80719   43.45568  -26.20944 1.000 12.47612 ? 93   PHE   B C   1 
ATOM   4335 O O   . PHE   B 1 111 ? 3.74287   43.71321  -25.00428 1.000 14.72124 ? 93   PHE   B O   1 
ATOM   4336 C CB  . PHE   B 1 111 ? 3.65657   41.13797  -27.14998 1.000 14.49688 ? 93   PHE   B CB  1 
ATOM   4337 C CG  . PHE   B 1 111 ? 4.33326   40.52900  -25.94102 1.000 17.63346 ? 93   PHE   B CG  1 
ATOM   4338 C CD1 . PHE   B 1 111 ? 3.60404   39.79686  -25.01708 1.000 17.11954 ? 93   PHE   B CD1 1 
ATOM   4339 C CD2 . PHE   B 1 111 ? 5.69133   40.71626  -25.71701 1.000 15.42821 ? 93   PHE   B CD2 1 
ATOM   4340 C CE1 . PHE   B 1 111 ? 4.21788   39.25165  -23.89908 1.000 17.61958 ? 93   PHE   B CE1 1 
ATOM   4341 C CE2 . PHE   B 1 111 ? 6.31056   40.17075  -24.60445 1.000 13.30724 ? 93   PHE   B CE2 1 
ATOM   4342 C CZ  . PHE   B 1 111 ? 5.57711   39.43580  -23.69600 1.000 15.20494 ? 93   PHE   B CZ  1 
ATOM   4343 N N   . THR   B 1 112 ? 4.68509   44.05900  -27.01820 1.000 13.05600 ? 94   THR   B N   1 
ATOM   4344 C CA  . THR   B 1 112 ? 5.67653   44.97150  -26.45399 1.000 9.87323  ? 94   THR   B CA  1 
ATOM   4345 C C   . THR   B 1 112 ? 5.01296   46.20802  -25.86637 1.000 18.41529 ? 94   THR   B C   1 
ATOM   4346 O O   . THR   B 1 112 ? 5.39283   46.66297  -24.78032 1.000 17.68173 ? 94   THR   B O   1 
ATOM   4347 C CB  . THR   B 1 112 ? 6.72230   45.36101  -27.50641 1.000 17.72830 ? 94   THR   B CB  1 
ATOM   4348 O OG1 . THR   B 1 112 ? 6.07308   45.94966  -28.63658 1.000 31.52086 ? 94   THR   B OG1 1 
ATOM   4349 C CG2 . THR   B 1 112 ? 7.52675   44.13855  -27.96113 1.000 16.47538 ? 94   THR   B CG2 1 
ATOM   4350 N N   . ALA   B 1 113 ? 4.01094   46.75644  -26.55982 1.000 17.05257 ? 95   ALA   B N   1 
ATOM   4351 C CA  . ALA   B 1 113 ? 3.27325   47.88422  -26.00327 1.000 18.34597 ? 95   ALA   B CA  1 
ATOM   4352 C C   . ALA   B 1 113 ? 2.63219   47.50848  -24.67821 1.000 16.64415 ? 95   ALA   B C   1 
ATOM   4353 O O   . ALA   B 1 113 ? 2.65834   48.29530  -23.72424 1.000 20.22669 ? 95   ALA   B O   1 
ATOM   4354 C CB  . ALA   B 1 113 ? 2.21206   48.36745  -26.99121 1.000 22.32339 ? 95   ALA   B CB  1 
ATOM   4355 N N   . GLN   B 1 114 ? 2.07156   46.29688  -24.59475 1.000 14.52529 ? 96   GLN   B N   1 
ATOM   4356 C CA  . GLN   B 1 114 ? 1.42461   45.85996  -23.36162 1.000 17.44445 ? 96   GLN   B CA  1 
ATOM   4357 C C   . GLN   B 1 114 ? 2.41823   45.80688  -22.20724 1.000 22.78049 ? 96   GLN   B C   1 
ATOM   4358 O O   . GLN   B 1 114 ? 2.13920   46.30019  -21.10686 1.000 21.14167 ? 96   GLN   B O   1 
ATOM   4359 C CB  . GLN   B 1 114 ? 0.76745   44.49311  -23.56246 1.000 18.55969 ? 96   GLN   B CB  1 
ATOM   4360 C CG  . GLN   B 1 114 ? 0.22703   43.91282  -22.26654 1.000 27.81897 ? 96   GLN   B CG  1 
ATOM   4361 C CD  . GLN   B 1 114 ? -0.41234  42.55428  -22.44521 1.000 28.89912 ? 96   GLN   B CD  1 
ATOM   4362 O OE1 . GLN   B 1 114 ? -0.38572  41.97453  -23.53307 1.000 29.71113 ? 96   GLN   B OE1 1 
ATOM   4363 N NE2 . GLN   B 1 114 ? -1.00090  42.03761  -21.36946 1.000 27.82400 ? 96   GLN   B NE2 1 
ATOM   4364 N N   . ILE   B 1 115 ? 3.58761   45.20588  -22.43828 1.000 14.57926 ? 97   ILE   B N   1 
ATOM   4365 C CA  . ILE   B 1 115 ? 4.56990   45.08092  -21.37033 1.000 11.60326 ? 97   ILE   B CA  1 
ATOM   4366 C C   . ILE   B 1 115 ? 5.14898   46.44335  -21.01605 1.000 18.39301 ? 97   ILE   B C   1 
ATOM   4367 O O   . ILE   B 1 115 ? 5.18146   46.83481  -19.84295 1.000 19.40964 ? 97   ILE   B O   1 
ATOM   4368 C CB  . ILE   B 1 115 ? 5.67985   44.08974  -21.76664 1.000 14.74314 ? 97   ILE   B CB  1 
ATOM   4369 C CG1 . ILE   B 1 115 ? 5.08010   42.74262  -22.18352 1.000 14.04190 ? 97   ILE   B CG1 1 
ATOM   4370 C CG2 . ILE   B 1 115 ? 6.67952   43.93710  -20.63085 1.000 18.42562 ? 97   ILE   B CG2 1 
ATOM   4371 C CD1 . ILE   B 1 115 ? 4.20248   42.10163  -21.12013 1.000 18.19486 ? 97   ILE   B CD1 1 
ATOM   4372 N N   . ARG   B 1 116 ? 5.63290   47.17588  -22.02207 1.000 18.32620 ? 98   ARG   B N   1 
ATOM   4373 C CA  . ARG   B 1 116 ? 6.25936   48.46866  -21.75922 1.000 18.89841 ? 98   ARG   B CA  1 
ATOM   4374 C C   . ARG   B 1 116 ? 5.29314   49.43860  -21.09235 1.000 24.21866 ? 98   ARG   B C   1 
ATOM   4375 O O   . ARG   B 1 116 ? 5.71192   50.26270  -20.27766 1.000 19.97370 ? 98   ARG   B O   1 
ATOM   4376 C CB  . ARG   B 1 116 ? 6.81507   49.05826  -23.05640 1.000 21.75900 ? 98   ARG   B CB  1 
ATOM   4377 C CG  . ARG   B 1 116 ? 8.20775   48.51744  -23.41182 1.000 27.71644 ? 98   ARG   B CG  1 
ATOM   4378 C CD  . ARG   B 1 116 ? 8.59252   48.71222  -24.88214 1.000 32.23993 ? 98   ARG   B CD  1 
ATOM   4379 N NE  . ARG   B 1 116 ? 9.66710   47.79651  -25.25598 1.000 43.94957 ? 98   ARG   B NE  1 
ATOM   4380 C CZ  . ARG   B 1 116 ? 9.97291   47.44260  -26.49837 1.000 54.41643 ? 98   ARG   B CZ  1 
ATOM   4381 N NH1 . ARG   B 1 116 ? 9.33343   47.95185  -27.54158 1.000 48.31495 ? 98   ARG   B NH1 1 
ATOM   4382 N NH2 . ARG   B 1 116 ? 10.93776  46.54394  -26.69834 1.000 39.16232 ? 98   ARG   B NH2 1 
ATOM   4383 N N   . GLY   B 1 117 ? 3.99711   49.33948  -21.39465 1.000 22.86957 ? 99   GLY   B N   1 
ATOM   4384 C CA  . GLY   B 1 117 ? 3.03469   50.22053  -20.75590 1.000 25.89995 ? 99   GLY   B CA  1 
ATOM   4385 C C   . GLY   B 1 117 ? 2.71888   49.84673  -19.32404 1.000 30.68339 ? 99   GLY   B C   1 
ATOM   4386 O O   . GLY   B 1 117 ? 2.39494   50.72009  -18.51314 1.000 21.49837 ? 99   GLY   B O   1 
ATOM   4387 N N   . ALA   B 1 118 ? 2.82156   48.56006  -18.98067 1.000 15.57723 ? 100  ALA   B N   1 
ATOM   4388 C CA  . ALA   B 1 118 ? 2.42817   48.10219  -17.65530 1.000 24.28381 ? 100  ALA   B CA  1 
ATOM   4389 C C   . ALA   B 1 118 ? 3.55092   48.17255  -16.63161 1.000 20.64217 ? 100  ALA   B C   1 
ATOM   4390 O O   . ALA   B 1 118 ? 3.26781   48.21142  -15.42916 1.000 23.63055 ? 100  ALA   B O   1 
ATOM   4391 C CB  . ALA   B 1 118 ? 1.90443   46.66183  -17.72717 1.000 24.91040 ? 100  ALA   B CB  1 
ATOM   4392 N N   . VAL   B 1 119 ? 4.80690   48.18894  -17.06947 1.000 23.29285 ? 101  VAL   B N   1 
ATOM   4393 C CA  . VAL   B 1 119 ? 5.96237   48.15449  -16.17709 1.000 21.29945 ? 101  VAL   B CA  1 
ATOM   4394 C C   . VAL   B 1 119 ? 6.77845   49.41434  -16.42019 1.000 27.64797 ? 101  VAL   B C   1 
ATOM   4395 O O   . VAL   B 1 119 ? 7.33103   49.60193  -17.51208 1.000 30.34576 ? 101  VAL   B O   1 
ATOM   4396 C CB  . VAL   B 1 119 ? 6.82556   46.90129  -16.40003 1.000 22.03830 ? 101  VAL   B CB  1 
ATOM   4397 C CG1 . VAL   B 1 119 ? 7.99279   46.87537  -15.41843 1.000 29.31780 ? 101  VAL   B CG1 1 
ATOM   4398 C CG2 . VAL   B 1 119 ? 5.99214   45.64232  -16.27066 1.000 18.45074 ? 101  VAL   B CG2 1 
ATOM   4399 N N   . ASP   B 1 120 ? 6.87342   50.26519  -15.40294 1.000 23.88891 ? 102  ASP   B N   1 
ATOM   4400 C CA  . ASP   B 1 120 ? 7.63202   51.50731  -15.49736 1.000 27.50712 ? 102  ASP   B CA  1 
ATOM   4401 C C   . ASP   B 1 120 ? 8.95805   51.24447  -14.78503 1.000 25.67854 ? 102  ASP   B C   1 
ATOM   4402 O O   . ASP   B 1 120 ? 9.00597   51.19248  -13.54972 1.000 23.11997 ? 102  ASP   B O   1 
ATOM   4403 C CB  . ASP   B 1 120 ? 6.83581   52.65350  -14.86590 1.000 31.25952 ? 102  ASP   B CB  1 
ATOM   4404 C CG  . ASP   B 1 120 ? 7.63579   53.95725  -14.69947 1.000 28.83456 ? 102  ASP   B CG  1 
ATOM   4405 O OD1 . ASP   B 1 120 ? 8.88479   53.96056  -14.62567 1.000 32.32685 ? 102  ASP   B OD1 1 
ATOM   4406 O OD2 . ASP   B 1 120 ? 6.96920   55.01447  -14.62319 1.000 39.72755 ? 102  ASP   B OD2 1 
ATOM   4407 N N   . LEU   B 1 121 ? 10.03253  51.07092  -15.56348 1.000 27.49252 ? 103  LEU   B N   1 
ATOM   4408 C CA  . LEU   B 1 121 ? 11.31868  50.66896  -14.99871 1.000 24.74504 ? 103  LEU   B CA  1 
ATOM   4409 C C   . LEU   B 1 121 ? 11.91867  51.72318  -14.07995 1.000 29.79614 ? 103  LEU   B C   1 
ATOM   4410 O O   . LEU   B 1 121 ? 12.81878  51.39758  -13.29935 1.000 31.43699 ? 103  LEU   B O   1 
ATOM   4411 C CB  . LEU   B 1 121 ? 12.31520  50.33586  -16.11018 1.000 22.56534 ? 103  LEU   B CB  1 
ATOM   4412 C CG  . LEU   B 1 121 ? 11.96840  49.13681  -16.99775 1.000 26.39468 ? 103  LEU   B CG  1 
ATOM   4413 C CD1 . LEU   B 1 121 ? 12.99392  48.95121  -18.09811 1.000 22.50133 ? 103  LEU   B CD1 1 
ATOM   4414 C CD2 . LEU   B 1 121 ? 11.87386  47.88047  -16.13998 1.000 28.60884 ? 103  LEU   B CD2 1 
ATOM   4415 N N   . SER   B 1 122 ? 11.44789  52.97084  -14.15151 1.000 27.83878 ? 104  SER   B N   1 
ATOM   4416 C CA  . SER   B 1 122 ? 11.96162  54.01327  -13.27020 1.000 28.51489 ? 104  SER   B CA  1 
ATOM   4417 C C   . SER   B 1 122 ? 11.52873  53.82832  -11.81835 1.000 32.03476 ? 104  SER   B C   1 
ATOM   4418 O O   . SER   B 1 122 ? 12.10013  54.47320  -10.93493 1.000 34.17954 ? 104  SER   B O   1 
ATOM   4419 C CB  . SER   B 1 122 ? 11.53270  55.39128  -13.79172 1.000 26.93079 ? 104  SER   B CB  1 
ATOM   4420 O OG  . SER   B 1 122 ? 10.24913  55.75093  -13.30972 1.000 30.91167 ? 104  SER   B OG  1 
ATOM   4421 N N   . LEU   B 1 123 ? 10.55875  52.95775  -11.54614 1.000 34.52923 ? 105  LEU   B N   1 
ATOM   4422 C CA  . LEU   B 1 123 ? 10.10667  52.69394  -10.18703 1.000 29.00608 ? 105  LEU   B CA  1 
ATOM   4423 C C   . LEU   B 1 123 ? 10.92835  51.62261  -9.48367  1.000 28.77025 ? 105  LEU   B C   1 
ATOM   4424 O O   . LEU   B 1 123 ? 10.66023  51.33421  -8.31549  1.000 32.55146 ? 105  LEU   B O   1 
ATOM   4425 C CB  . LEU   B 1 123 ? 8.63579   52.26844  -10.19197 1.000 29.26532 ? 105  LEU   B CB  1 
ATOM   4426 C CG  . LEU   B 1 123 ? 7.61630   53.28197  -10.70988 1.000 37.82698 ? 105  LEU   B CG  1 
ATOM   4427 C CD1 . LEU   B 1 123 ? 6.22905   52.63599  -10.82522 1.000 35.41101 ? 105  LEU   B CD1 1 
ATOM   4428 C CD2 . LEU   B 1 123 ? 7.57666   54.53130  -9.83266  1.000 28.90212 ? 105  LEU   B CD2 1 
ATOM   4429 N N   . TYR   B 1 124 ? 11.91510  51.03534  -10.15921 1.000 33.23880 ? 106  TYR   B N   1 
ATOM   4430 C CA  . TYR   B 1 124 ? 12.65997  49.88787  -9.63428  1.000 39.11483 ? 106  TYR   B CA  1 
ATOM   4431 C C   . TYR   B 1 124 ? 14.17172  50.10041  -9.67051  1.000 32.51168 ? 106  TYR   B C   1 
ATOM   4432 O O   . TYR   B 1 124 ? 14.77477  50.16415  -10.73789 1.000 50.30087 ? 106  TYR   B O   1 
ATOM   4433 C CB  . TYR   B 1 124 ? 12.27373  48.62262  -10.41310 1.000 26.14275 ? 106  TYR   B CB  1 
ATOM   4434 C CG  . TYR   B 1 124 ? 10.81461  48.26430  -10.25349 1.000 25.98059 ? 106  TYR   B CG  1 
ATOM   4435 C CD1 . TYR   B 1 124 ? 10.38576  47.53165  -9.15687  1.000 27.56355 ? 106  TYR   B CD1 1 
ATOM   4436 C CD2 . TYR   B 1 124 ? 9.85798   48.69862  -11.16388 1.000 26.29359 ? 106  TYR   B CD2 1 
ATOM   4437 C CE1 . TYR   B 1 124 ? 9.04947   47.20785  -8.98423  1.000 31.60518 ? 106  TYR   B CE1 1 
ATOM   4438 C CE2 . TYR   B 1 124 ? 8.51156   48.38185  -10.99689 1.000 28.04406 ? 106  TYR   B CE2 1 
ATOM   4439 C CZ  . TYR   B 1 124 ? 8.11697   47.63423  -9.90210  1.000 22.67767 ? 106  TYR   B CZ  1 
ATOM   4440 O OH  . TYR   B 1 124 ? 6.79121   47.31221  -9.71315  1.000 26.31959 ? 106  TYR   B OH  1 
ATOM   4441 N N   . VAL   B 1 130 ? 21.17006  43.98439  -12.36138 1.000 33.50093 ? 112  VAL   B N   1 
ATOM   4442 C CA  . VAL   B 1 130 ? 20.45598  43.09755  -11.45509 1.000 40.60391 ? 112  VAL   B CA  1 
ATOM   4443 C C   . VAL   B 1 130 ? 19.00537  43.51443  -11.33293 1.000 50.06664 ? 112  VAL   B C   1 
ATOM   4444 O O   . VAL   B 1 130 ? 18.69853  44.60176  -10.83613 1.000 37.32659 ? 112  VAL   B O   1 
ATOM   4445 C CB  . VAL   B 1 130 ? 21.10020  43.06703  -10.05957 1.000 45.26565 ? 112  VAL   B CB  1 
ATOM   4446 C CG1 . VAL   B 1 130 ? 20.60462  41.85507  -9.27819  1.000 44.93371 ? 112  VAL   B CG1 1 
ATOM   4447 C CG2 . VAL   B 1 130 ? 22.61953  43.07576  -10.16734 1.000 48.09796 ? 112  VAL   B CG2 1 
ATOM   4448 N N   . SER   B 1 131 ? 18.10682  42.64541  -11.77720 1.000 31.71283 ? 113  SER   B N   1 
ATOM   4449 C CA  . SER   B 1 131 ? 16.68926  42.88459  -11.57904 1.000 27.92318 ? 113  SER   B CA  1 
ATOM   4450 C C   . SER   B 1 131 ? 16.32917  42.54116  -10.14144 1.000 31.07446 ? 113  SER   B C   1 
ATOM   4451 O O   . SER   B 1 131 ? 16.70843  41.48033  -9.63233  1.000 30.17929 ? 113  SER   B O   1 
ATOM   4452 C CB  . SER   B 1 131 ? 15.86574  42.05458  -12.55744 1.000 20.43616 ? 113  SER   B CB  1 
ATOM   4453 O OG  . SER   B 1 131 ? 16.19193  42.40381  -13.88721 1.000 23.50623 ? 113  SER   B OG  1 
ATOM   4454 N N   . SER   B 1 132 ? 15.63030  43.45461  -9.47615  1.000 23.02228 ? 114  SER   B N   1 
ATOM   4455 C CA  . SER   B 1 132 ? 15.16395  43.18564  -8.13094  1.000 28.59682 ? 114  SER   B CA  1 
ATOM   4456 C C   . SER   B 1 132 ? 14.08031  42.11797  -8.17143  1.000 24.22827 ? 114  SER   B C   1 
ATOM   4457 O O   . SER   B 1 132 ? 13.45326  41.87694  -9.20820  1.000 22.50339 ? 114  SER   B O   1 
ATOM   4458 C CB  . SER   B 1 132 ? 14.63258  44.46527  -7.48503  1.000 25.93795 ? 114  SER   B CB  1 
ATOM   4459 O OG  . SER   B 1 132 ? 13.40386  44.85195  -8.07548  1.000 23.58507 ? 114  SER   B OG  1 
ATOM   4460 N N   . ARG   B 1 133 ? 13.86192  41.46440  -7.02459  1.000 29.30754 ? 115  ARG   B N   1 
ATOM   4461 C CA  . ARG   B 1 133 ? 12.75675  40.51528  -6.93974  1.000 25.73665 ? 115  ARG   B CA  1 
ATOM   4462 C C   . ARG   B 1 133 ? 11.42704  41.20624  -7.20001  1.000 22.80646 ? 115  ARG   B C   1 
ATOM   4463 O O   . ARG   B 1 133 ? 10.53495  40.63966  -7.84416  1.000 22.67379 ? 115  ARG   B O   1 
ATOM   4464 C CB  . ARG   B 1 133 ? 12.71703  39.81793  -5.57357  1.000 21.86761 ? 115  ARG   B CB  1 
ATOM   4465 C CG  . ARG   B 1 133 ? 11.43737  38.97535  -5.40496  1.000 22.46989 ? 115  ARG   B CG  1 
ATOM   4466 C CD  . ARG   B 1 133 ? 11.40458  38.09692  -4.14840  1.000 24.58792 ? 115  ARG   B CD  1 
ATOM   4467 N NE  . ARG   B 1 133 ? 12.59534  37.27679  -4.13123  1.000 30.25102 ? 115  ARG   B NE  1 
ATOM   4468 C CZ  . ARG   B 1 133 ? 12.65329  36.00663  -4.49871  1.000 19.56596 ? 115  ARG   B CZ  1 
ATOM   4469 N NH1 . ARG   B 1 133 ? 11.55889  35.29945  -4.74782  1.000 14.35558 ? 115  ARG   B NH1 1 
ATOM   4470 N NH2 . ARG   B 1 133 ? 13.84369  35.43894  -4.64583  1.000 26.88250 ? 115  ARG   B NH2 1 
ATOM   4471 N N   . GLU   B 1 134 ? 11.26419  42.42842  -6.69151  1.000 22.99780 ? 116  GLU   B N   1 
ATOM   4472 C CA  . GLU   B 1 134 ? 9.99545   43.12025  -6.88380  1.000 19.39078 ? 116  GLU   B CA  1 
ATOM   4473 C C   . GLU   B 1 134 ? 9.74935   43.40256  -8.35733  1.000 15.16019 ? 116  GLU   B C   1 
ATOM   4474 O O   . GLU   B 1 134 ? 8.61263   43.30183  -8.83191  1.000 18.31290 ? 116  GLU   B O   1 
ATOM   4475 C CB  . GLU   B 1 134 ? 9.96052   44.40625  -6.05362  1.000 25.19147 ? 116  GLU   B CB  1 
ATOM   4476 C CG  . GLU   B 1 134 ? 9.86207   44.14393  -4.54797  1.000 36.01410 ? 116  GLU   B CG  1 
ATOM   4477 C CD  . GLU   B 1 134 ? 8.82172   43.07464  -4.19996  1.000 38.41072 ? 116  GLU   B CD  1 
ATOM   4478 O OE1 . GLU   B 1 134 ? 7.66191   43.20285  -4.65634  1.000 34.51511 ? 116  GLU   B OE1 1 
ATOM   4479 O OE2 . GLU   B 1 134 ? 9.16275   42.10456  -3.47889  1.000 31.50458 ? 116  GLU   B OE2 1 
ATOM   4480 N N   . LEU   B 1 135 ? 10.80825  43.72199  -9.10276  1.000 16.15433 ? 117  LEU   B N   1 
ATOM   4481 C CA  . LEU   B 1 135 ? 10.66470  43.92017  -10.54032 1.000 18.73302 ? 117  LEU   B CA  1 
ATOM   4482 C C   . LEU   B 1 135 ? 10.24191  42.62686  -11.22793 1.000 18.16876 ? 117  LEU   B C   1 
ATOM   4483 O O   . LEU   B 1 135 ? 9.35224   42.62589  -12.08346 1.000 16.79038 ? 117  LEU   B O   1 
ATOM   4484 C CB  . LEU   B 1 135 ? 11.97733  44.43878  -11.12761 1.000 16.86705 ? 117  LEU   B CB  1 
ATOM   4485 C CG  . LEU   B 1 135 ? 12.00420  44.64956  -12.64509 1.000 20.74421 ? 117  LEU   B CG  1 
ATOM   4486 C CD1 . LEU   B 1 135 ? 10.80568  45.46468  -13.08848 1.000 21.96060 ? 117  LEU   B CD1 1 
ATOM   4487 C CD2 . LEU   B 1 135 ? 13.29752  45.29276  -13.10026 1.000 18.24000 ? 117  LEU   B CD2 1 
ATOM   4488 N N   . VAL   B 1 136 ? 10.88427  41.51032  -10.87387 1.000 16.40096 ? 118  VAL   B N   1 
ATOM   4489 C CA  . VAL   B 1 136 ? 10.53544  40.23953  -11.49796 1.000 21.71130 ? 118  VAL   B CA  1 
ATOM   4490 C C   . VAL   B 1 136 ? 9.09525   39.87433  -11.17622 1.000 15.42401 ? 118  VAL   B C   1 
ATOM   4491 O O   . VAL   B 1 136 ? 8.34331   39.44207  -12.05309 1.000 14.87740 ? 118  VAL   B O   1 
ATOM   4492 C CB  . VAL   B 1 136 ? 11.51406  39.13524  -11.06397 1.000 19.64638 ? 118  VAL   B CB  1 
ATOM   4493 C CG1 . VAL   B 1 136 ? 11.04771  37.78338  -11.60231 1.000 20.90408 ? 118  VAL   B CG1 1 
ATOM   4494 C CG2 . VAL   B 1 136 ? 12.91458  39.45198  -11.54251 1.000 17.66068 ? 118  VAL   B CG2 1 
ATOM   4495 N N   . LYS   B 1 137 ? 8.67554   40.07388  -9.92161  1.000 13.73200 ? 119  LYS   B N   1 
ATOM   4496 C CA  . LYS   B 1 137 ? 7.29057   39.78310  -9.56624  1.000 18.10988 ? 119  LYS   B CA  1 
ATOM   4497 C C   . LYS   B 1 137 ? 6.32102   40.68964  -10.31040 1.000 13.25217 ? 119  LYS   B C   1 
ATOM   4498 O O   . LYS   B 1 137 ? 5.21779   40.25906  -10.66218 1.000 17.76862 ? 119  LYS   B O   1 
ATOM   4499 C CB  . LYS   B 1 137 ? 7.09371   39.91100  -8.05144  1.000 22.73850 ? 119  LYS   B CB  1 
ATOM   4500 C CG  . LYS   B 1 137 ? 7.73626   38.78858  -7.25118  1.000 26.52890 ? 119  LYS   B CG  1 
ATOM   4501 C CD  . LYS   B 1 137 ? 7.98773   39.18445  -5.79742  1.000 26.68051 ? 119  LYS   B CD  1 
ATOM   4502 C CE  . LYS   B 1 137 ? 6.74469   39.65783  -5.08119  1.000 31.12570 ? 119  LYS   B CE  1 
ATOM   4503 N NZ  . LYS   B 1 137 ? 7.07966   40.00823  -3.66568  1.000 31.42911 ? 119  LYS   B NZ  1 
ATOM   4504 N N   . LYS   B 1 138 ? 6.71381   41.94108  -10.56083 1.000 17.65990 ? 120  LYS   B N   1 
ATOM   4505 C CA  . LYS   B 1 138 ? 5.83629   42.86625  -11.27028 1.000 15.69897 ? 120  LYS   B CA  1 
ATOM   4506 C C   . LYS   B 1 138 ? 5.60984   42.41756  -12.70767 1.000 10.73010 ? 120  LYS   B C   1 
ATOM   4507 O O   . LYS   B 1 138 ? 4.47496   42.42703  -13.20126 1.000 16.39701 ? 120  LYS   B O   1 
ATOM   4508 C CB  . LYS   B 1 138 ? 6.42786   44.27841  -11.23288 1.000 20.82071 ? 120  LYS   B CB  1 
ATOM   4509 C CG  . LYS   B 1 138 ? 5.73039   45.23033  -12.17940 1.000 18.85379 ? 120  LYS   B CG  1 
ATOM   4510 C CD  . LYS   B 1 138 ? 4.31507   45.50832  -11.71567 1.000 21.40981 ? 120  LYS   B CD  1 
ATOM   4511 C CE  . LYS   B 1 138 ? 3.69389   46.63053  -12.52480 1.000 23.99667 ? 120  LYS   B CE  1 
ATOM   4512 N NZ  . LYS   B 1 138 ? 2.21699   46.52264  -12.54400 1.000 30.87561 ? 120  LYS   B NZ  1 
ATOM   4513 N N   . VAL   B 1 139 ? 6.68613   42.05446  -13.40810 1.000 14.66905 ? 121  VAL   B N   1 
ATOM   4514 C CA  . VAL   B 1 139 ? 6.54735   41.53453  -14.76823 1.000 17.13039 ? 121  VAL   B CA  1 
ATOM   4515 C C   . VAL   B 1 139 ? 5.73154   40.24939  -14.75340 1.000 16.74668 ? 121  VAL   B C   1 
ATOM   4516 O O   . VAL   B 1 139 ? 4.82887   40.05024  -15.57848 1.000 13.48219 ? 121  VAL   B O   1 
ATOM   4517 C CB  . VAL   B 1 139 ? 7.93843   41.31178  -15.39363 1.000 17.43920 ? 121  VAL   B CB  1 
ATOM   4518 C CG1 . VAL   B 1 139 ? 7.80995   40.69556  -16.77579 1.000 13.20121 ? 121  VAL   B CG1 1 
ATOM   4519 C CG2 . VAL   B 1 139 ? 8.73432   42.62683  -15.42649 1.000 15.28525 ? 121  VAL   B CG2 1 
ATOM   4520 N N   . SER   B 1 140 ? 6.03591   39.36141  -13.80535 1.000 13.90583 ? 122  SER   B N   1 
ATOM   4521 C CA  . SER   B 1 140 ? 5.24599   38.15012  -13.62123 1.000 14.00366 ? 122  SER   B CA  1 
ATOM   4522 C C   . SER   B 1 140 ? 3.76346   38.47208  -13.47321 1.000 13.73502 ? 122  SER   B C   1 
ATOM   4523 O O   . SER   B 1 140 ? 2.91092   37.84227  -14.11363 1.000 15.69392 ? 122  SER   B O   1 
ATOM   4524 C CB  . SER   B 1 140 ? 5.76558   37.39462  -12.39688 1.000 17.35400 ? 122  SER   B CB  1 
ATOM   4525 O OG  . SER   B 1 140 ? 5.04101   36.20320  -12.17058 1.000 17.72252 ? 122  SER   B OG  1 
ATOM   4526 N N   . ASP   B 1 141 ? 3.44354   39.47068  -12.64090 1.000 16.44382 ? 123  ASP   B N   1 
ATOM   4527 C CA  . ASP   B 1 141 ? 2.04923   39.83442  -12.38959 1.000 20.69428 ? 123  ASP   B CA  1 
ATOM   4528 C C   . ASP   B 1 141 ? 1.34799   40.31744  -13.65237 1.000 14.78036 ? 123  ASP   B C   1 
ATOM   4529 O O   . ASP   B 1 141 ? 0.16101   40.03463  -13.85653 1.000 22.17137 ? 123  ASP   B O   1 
ATOM   4530 C CB  . ASP   B 1 141 ? 1.97303   40.91960  -11.31214 1.000 19.02346 ? 123  ASP   B CB  1 
ATOM   4531 C CG  . ASP   B 1 141 ? 2.16083   40.37213  -9.91780  1.000 26.82177 ? 123  ASP   B CG  1 
ATOM   4532 O OD1 . ASP   B 1 141 ? 2.18380   39.13658  -9.75440  1.000 25.47891 ? 123  ASP   B OD1 1 
ATOM   4533 O OD2 . ASP   B 1 141 ? 2.29897   41.18096  -8.98077  1.000 27.47360 ? 123  ASP   B OD2 1 
ATOM   4534 N N   . VAL   B 1 142 ? 2.04585   41.09234  -14.48570 1.000 17.71417 ? 124  VAL   B N   1 
ATOM   4535 C CA  . VAL   B 1 142 ? 1.44685   41.57114  -15.72887 1.000 12.81936 ? 124  VAL   B CA  1 
ATOM   4536 C C   . VAL   B 1 142 ? 1.01070   40.39821  -16.59659 1.000 19.15567 ? 124  VAL   B C   1 
ATOM   4537 O O   . VAL   B 1 142 ? -0.10505  40.37770  -17.12919 1.000 16.46610 ? 124  VAL   B O   1 
ATOM   4538 C CB  . VAL   B 1 142 ? 2.42436   42.49187  -16.47596 1.000 18.49827 ? 124  VAL   B CB  1 
ATOM   4539 C CG1 . VAL   B 1 142 ? 1.89224   42.79202  -17.87273 1.000 17.66286 ? 124  VAL   B CG1 1 
ATOM   4540 C CG2 . VAL   B 1 142 ? 2.64269   43.77776  -15.68467 1.000 19.24639 ? 124  VAL   B CG2 1 
ATOM   4541 N N   . ILE   B 1 143 ? 1.88739   39.40254  -16.75201 1.000 15.74601 ? 125  ILE   B N   1 
ATOM   4542 C CA  . ILE   B 1 143 ? 1.54281   38.21973  -17.53369 1.000 10.86821 ? 125  ILE   B CA  1 
ATOM   4543 C C   . ILE   B 1 143 ? 0.37304   37.48523  -16.89311 1.000 11.83579 ? 125  ILE   B C   1 
ATOM   4544 O O   . ILE   B 1 143 ? -0.62560  37.16901  -17.54949 1.000 14.55560 ? 125  ILE   B O   1 
ATOM   4545 C CB  . ILE   B 1 143 ? 2.76797   37.29410  -17.67632 1.000 11.82633 ? 125  ILE   B CB  1 
ATOM   4546 C CG1 . ILE   B 1 143 ? 3.92435   38.01184  -18.38599 1.000 16.54800 ? 125  ILE   B CG1 1 
ATOM   4547 C CG2 . ILE   B 1 143 ? 2.38303   36.00095  -18.38701 1.000 15.75202 ? 125  ILE   B CG2 1 
ATOM   4548 C CD1 . ILE   B 1 143 ? 3.64783   38.33829  -19.83859 1.000 16.34684 ? 125  ILE   B CD1 1 
ATOM   4549 N N   . TRP   B 1 144 ? 0.48910   37.21281  -15.59214 1.000 12.45401 ? 126  TRP   B N   1 
ATOM   4550 C CA  . TRP   B 1 144 ? -0.48660  36.39860  -14.87412 1.000 14.18292 ? 126  TRP   B CA  1 
ATOM   4551 C C   . TRP   B 1 144 ? -1.87473  37.02008  -14.94147 1.000 15.31879 ? 126  TRP   B C   1 
ATOM   4552 O O   . TRP   B 1 144 ? -2.85993  36.34497  -15.26321 1.000 16.47759 ? 126  TRP   B O   1 
ATOM   4553 C CB  . TRP   B 1 144 ? -0.01074  36.25876  -13.42662 1.000 11.83478 ? 126  TRP   B CB  1 
ATOM   4554 C CG  . TRP   B 1 144 ? -0.72526  35.29346  -12.54058 1.000 18.62614 ? 126  TRP   B CG  1 
ATOM   4555 C CD1 . TRP   B 1 144 ? -1.52462  35.60166  -11.46911 1.000 19.81746 ? 126  TRP   B CD1 1 
ATOM   4556 C CD2 . TRP   B 1 144 ? -0.65332  33.85974  -12.58818 1.000 17.87036 ? 126  TRP   B CD2 1 
ATOM   4557 N NE1 . TRP   B 1 144 ? -1.96836  34.44886  -10.86633 1.000 23.11013 ? 126  TRP   B NE1 1 
ATOM   4558 C CE2 . TRP   B 1 144 ? -1.44790  33.36771  -11.52875 1.000 20.37729 ? 126  TRP   B CE2 1 
ATOM   4559 C CE3 . TRP   B 1 144 ? 0.00650   32.94296  -13.42321 1.000 18.47888 ? 126  TRP   B CE3 1 
ATOM   4560 C CZ2 . TRP   B 1 144 ? -1.61601  32.00327  -11.29013 1.000 20.69010 ? 126  TRP   B CZ2 1 
ATOM   4561 C CZ3 . TRP   B 1 144 ? -0.16505  31.58216  -13.18473 1.000 16.74160 ? 126  TRP   B CZ3 1 
ATOM   4562 C CH2 . TRP   B 1 144 ? -0.96642  31.12917  -12.12233 1.000 15.44625 ? 126  TRP   B CH2 1 
ATOM   4563 N N   . ASN   B 1 145 ? -1.96560  38.31895  -14.66409 1.000 17.73767 ? 127  ASN   B N   1 
ATOM   4564 C CA  . ASN   B 1 145 ? -3.25698  38.99073  -14.60791 1.000 18.19334 ? 127  ASN   B CA  1 
ATOM   4565 C C   . ASN   B 1 145 ? -3.85006  39.25556  -15.97868 1.000 18.78372 ? 127  ASN   B C   1 
ATOM   4566 O O   . ASN   B 1 145 ? -5.01067  39.66830  -16.05847 1.000 21.03346 ? 127  ASN   B O   1 
ATOM   4567 C CB  . ASN   B 1 145 ? -3.13139  40.30476  -13.83670 1.000 21.12706 ? 127  ASN   B CB  1 
ATOM   4568 C CG  . ASN   B 1 145 ? -2.81737  40.08354  -12.38275 1.000 24.21899 ? 127  ASN   B CG  1 
ATOM   4569 O OD1 . ASN   B 1 145 ? -3.32747  39.14657  -11.76477 1.000 24.20399 ? 127  ASN   B OD1 1 
ATOM   4570 N ND2 . ASN   B 1 145 ? -1.97267  40.93452  -11.82357 1.000 29.16322 ? 127  ASN   B ND2 1 
ATOM   4571 N N   . SER   B 1 146 ? -3.09569  39.02306  -17.04930 1.000 17.29380 ? 128  SER   B N   1 
ATOM   4572 C CA  . SER   B 1 146 ? -3.61182  39.18139  -18.40248 1.000 19.07897 ? 128  SER   B CA  1 
ATOM   4573 C C   . SER   B 1 146 ? -4.29998  37.93190  -18.91452 1.000 18.86399 ? 128  SER   B C   1 
ATOM   4574 O O   . SER   B 1 146 ? -5.04933  38.01096  -19.89450 1.000 20.17214 ? 128  SER   B O   1 
ATOM   4575 C CB  . SER   B 1 146 ? -2.47685  39.55496  -19.36739 1.000 22.30220 ? 128  SER   B CB  1 
ATOM   4576 O OG  . SER   B 1 146 ? -1.68628  40.59207  -18.81847 1.000 30.59337 ? 128  SER   B OG  1 
ATOM   4577 N N   . LEU   B 1 147 ? -4.05756  36.78733  -18.27858 1.000 17.11376 ? 129  LEU   B N   1 
ATOM   4578 C CA  . LEU   B 1 147 ? -4.63068  35.52251  -18.71482 1.000 13.63990 ? 129  LEU   B CA  1 
ATOM   4579 C C   . LEU   B 1 147 ? -6.13499  35.47997  -18.45952 1.000 19.45762 ? 129  LEU   B C   1 
ATOM   4580 O O   . LEU   B 1 147 ? -6.63800  36.06849  -17.49829 1.000 20.00505 ? 129  LEU   B O   1 
ATOM   4581 C CB  . LEU   B 1 147 ? -3.94247  34.36775  -17.98692 1.000 12.59549 ? 129  LEU   B CB  1 
ATOM   4582 C CG  . LEU   B 1 147 ? -2.43395  34.26893  -18.22171 1.000 18.76018 ? 129  LEU   B CG  1 
ATOM   4583 C CD1 . LEU   B 1 147 ? -1.78839  33.34811  -17.20433 1.000 18.22055 ? 129  LEU   B CD1 1 
ATOM   4584 C CD2 . LEU   B 1 147 ? -2.15333  33.78299  -19.63320 1.000 15.69840 ? 129  LEU   B CD2 1 
ATOM   4585 N N   . SER   B 1 148 ? -6.85590  34.77610  -19.33825 1.000 18.51843 ? 130  SER   B N   1 
ATOM   4586 C CA  . SER   B 1 148 ? -8.27287  34.51831  -19.10065 1.000 22.77094 ? 130  SER   B CA  1 
ATOM   4587 C C   . SER   B 1 148 ? -8.47424  33.89246  -17.72647 1.000 26.73918 ? 130  SER   B C   1 
ATOM   4588 O O   . SER   B 1 148 ? -7.61877  33.16375  -17.21330 1.000 17.25197 ? 130  SER   B O   1 
ATOM   4589 C CB  . SER   B 1 148 ? -8.87104  33.60486  -20.17885 1.000 21.82403 ? 130  SER   B CB  1 
ATOM   4590 O OG  . SER   B 1 148 ? -8.55907  34.05808  -21.48581 1.000 23.71885 ? 130  SER   B OG  1 
ATOM   4591 N N   . ARG   B 1 149 ? -9.61518  34.19862  -17.11678 1.000 19.81309 ? 131  ARG   B N   1 
ATOM   4592 C CA  . ARG   B 1 149 ? -9.85155  33.76378  -15.74897 1.000 26.24209 ? 131  ARG   B CA  1 
ATOM   4593 C C   . ARG   B 1 149 ? -10.21780 32.28972  -15.65645 1.000 26.61223 ? 131  ARG   B C   1 
ATOM   4594 O O   . ARG   B 1 149 ? -10.08088 31.70735  -14.57714 1.000 38.77581 ? 131  ARG   B O   1 
ATOM   4595 C CB  . ARG   B 1 149 ? -10.95360 34.61314  -15.10786 1.000 34.75706 ? 131  ARG   B CB  1 
ATOM   4596 N N   . SER   B 1 150 ? -10.66360 31.67347  -16.75285 1.000 23.49632 ? 132  SER   B N   1 
ATOM   4597 C CA  . SER   B 1 150 ? -11.09122 30.27510  -16.71808 1.000 28.72033 ? 132  SER   B CA  1 
ATOM   4598 C C   . SER   B 1 150 ? -10.79525 29.61112  -18.05537 1.000 27.16684 ? 132  SER   B C   1 
ATOM   4599 O O   . SER   B 1 150 ? -11.39699 29.96530  -19.07147 1.000 29.41080 ? 132  SER   B O   1 
ATOM   4600 C CB  . SER   B 1 150 ? -12.57699 30.16748  -16.38285 1.000 35.94034 ? 132  SER   B CB  1 
ATOM   4601 O OG  . SER   B 1 150 ? -12.76516 30.07592  -14.97968 1.000 43.06251 ? 132  SER   B OG  1 
ATOM   4602 N N   . TYR   B 1 151 ? -9.88346  28.63961  -18.04635 1.000 19.34787 ? 133  TYR   B N   1 
ATOM   4603 C CA  . TYR   B 1 151 ? -9.63860  27.79187  -19.20290 1.000 17.92024 ? 133  TYR   B CA  1 
ATOM   4604 C C   . TYR   B 1 151 ? -8.88124  26.56188  -18.73153 1.000 12.96019 ? 133  TYR   B C   1 
ATOM   4605 O O   . TYR   B 1 151 ? -8.30657  26.54643  -17.63941 1.000 17.71685 ? 133  TYR   B O   1 
ATOM   4606 C CB  . TYR   B 1 151 ? -8.85034  28.51131  -20.30757 1.000 21.14968 ? 133  TYR   B CB  1 
ATOM   4607 C CG  . TYR   B 1 151 ? -7.45917  28.96770  -19.90037 1.000 19.94400 ? 133  TYR   B CG  1 
ATOM   4608 C CD1 . TYR   B 1 151 ? -7.27101  30.19051  -19.28129 1.000 16.83471 ? 133  TYR   B CD1 1 
ATOM   4609 C CD2 . TYR   B 1 151 ? -6.33798  28.18008  -20.14740 1.000 18.09424 ? 133  TYR   B CD2 1 
ATOM   4610 C CE1 . TYR   B 1 151 ? -6.01001  30.62770  -18.90796 1.000 19.95452 ? 133  TYR   B CE1 1 
ATOM   4611 C CE2 . TYR   B 1 151 ? -5.06615  28.61138  -19.78009 1.000 12.08794 ? 133  TYR   B CE2 1 
ATOM   4612 C CZ  . TYR   B 1 151 ? -4.91042  29.83331  -19.16098 1.000 15.69761 ? 133  TYR   B CZ  1 
ATOM   4613 O OH  . TYR   B 1 151 ? -3.66344  30.27659  -18.78752 1.000 16.63450 ? 133  TYR   B OH  1 
ATOM   4614 N N   . PHE   B 1 152 ? -8.87950  25.54134  -19.57899 1.000 19.51570 ? 134  PHE   B N   1 
ATOM   4615 C CA  . PHE   B 1 152 ? -8.18509  24.28502  -19.30662 1.000 17.23365 ? 134  PHE   B CA  1 
ATOM   4616 C C   . PHE   B 1 152 ? -6.69921  24.46866  -19.60809 1.000 14.85086 ? 134  PHE   B C   1 
ATOM   4617 O O   . PHE   B 1 152 ? -6.29529  24.53779  -20.77476 1.000 18.01289 ? 134  PHE   B O   1 
ATOM   4618 C CB  . PHE   B 1 152 ? -8.79316  23.16770  -20.15154 1.000 17.61115 ? 134  PHE   B CB  1 
ATOM   4619 C CG  . PHE   B 1 152 ? -8.22546  21.80992  -19.86827 1.000 17.48062 ? 134  PHE   B CG  1 
ATOM   4620 C CD1 . PHE   B 1 152 ? -8.00135  21.39472  -18.56637 1.000 16.75606 ? 134  PHE   B CD1 1 
ATOM   4621 C CD2 . PHE   B 1 152 ? -7.92072  20.94349  -20.90543 1.000 18.99606 ? 134  PHE   B CD2 1 
ATOM   4622 C CE1 . PHE   B 1 152 ? -7.48218  20.14006  -18.30463 1.000 16.56044 ? 134  PHE   B CE1 1 
ATOM   4623 C CE2 . PHE   B 1 152 ? -7.39729  19.68006  -20.64732 1.000 19.72138 ? 134  PHE   B CE2 1 
ATOM   4624 C CZ  . PHE   B 1 152 ? -7.17267  19.28364  -19.35071 1.000 23.62509 ? 134  PHE   B CZ  1 
ATOM   4625 N N   . LYS   B 1 153 ? -5.87895  24.53413  -18.56321 1.000 16.21666 ? 135  LYS   B N   1 
ATOM   4626 C CA  . LYS   B 1 153 ? -4.47545  24.88732  -18.74415 1.000 15.33180 ? 135  LYS   B CA  1 
ATOM   4627 C C   . LYS   B 1 153 ? -3.62120  23.74861  -19.28762 1.000 17.47645 ? 135  LYS   B C   1 
ATOM   4628 O O   . LYS   B 1 153 ? -2.43454  23.96995  -19.56214 1.000 18.37698 ? 135  LYS   B O   1 
ATOM   4629 C CB  . LYS   B 1 153 ? -3.89689  25.40905  -17.42365 1.000 21.49706 ? 135  LYS   B CB  1 
ATOM   4630 C CG  . LYS   B 1 153 ? -3.81123  24.36435  -16.32338 1.000 25.58556 ? 135  LYS   B CG  1 
ATOM   4631 C CD  . LYS   B 1 153 ? -3.12565  24.94515  -15.09133 1.000 33.87190 ? 135  LYS   B CD  1 
ATOM   4632 C CE  . LYS   B 1 153 ? -4.14562  25.44438  -14.06399 1.000 40.07267 ? 135  LYS   B CE  1 
ATOM   4633 N NZ  . LYS   B 1 153 ? -5.42073  24.65025  -14.01364 1.000 31.62836 ? 135  LYS   B NZ  1 
ATOM   4634 N N   . ASP   B 1 154 ? -4.16966  22.54805  -19.46024 1.000 17.85318 ? 136  ASP   B N   1 
ATOM   4635 C CA  . ASP   B 1 154 ? -3.44342  21.46812  -20.11864 1.000 20.67632 ? 136  ASP   B CA  1 
ATOM   4636 C C   . ASP   B 1 154 ? -3.85589  21.29702  -21.57436 1.000 20.49308 ? 136  ASP   B C   1 
ATOM   4637 O O   . ASP   B 1 154 ? -3.51734  20.28795  -22.19769 1.000 24.67780 ? 136  ASP   B O   1 
ATOM   4638 C CB  . ASP   B 1 154 ? -3.62635  20.15826  -19.35349 1.000 31.29096 ? 136  ASP   B CB  1 
ATOM   4639 C CG  . ASP   B 1 154 ? -2.38335  19.29191  -19.39350 1.000 58.09358 ? 136  ASP   B CG  1 
ATOM   4640 O OD1 . ASP   B 1 154 ? -1.54757  19.41665  -18.46982 1.000 58.19241 ? 136  ASP   B OD1 1 
ATOM   4641 O OD2 . ASP   B 1 154 ? -2.24559  18.48439  -20.34324 1.000 62.63441 ? 136  ASP   B OD2 1 
ATOM   4642 N N   . ARG   B 1 155 ? -4.57383  22.26951  -22.12261 1.000 17.00092 ? 137  ARG   B N   1 
ATOM   4643 C CA  . ARG   B 1 155 ? -4.94431  22.26509  -23.52684 1.000 17.44512 ? 137  ARG   B CA  1 
ATOM   4644 C C   . ARG   B 1 155 ? -3.69883  22.23155  -24.40781 1.000 18.29797 ? 137  ARG   B C   1 
ATOM   4645 O O   . ARG   B 1 155 ? -2.62382  22.69185  -24.01513 1.000 14.49205 ? 137  ARG   B O   1 
ATOM   4646 C CB  . ARG   B 1 155 ? -5.74641  23.52575  -23.82591 1.000 20.28705 ? 137  ARG   B CB  1 
ATOM   4647 C CG  . ARG   B 1 155 ? -6.89187  23.36507  -24.76385 1.000 36.53534 ? 137  ARG   B CG  1 
ATOM   4648 C CD  . ARG   B 1 155 ? -7.79008  24.57134  -24.60630 1.000 26.25943 ? 137  ARG   B CD  1 
ATOM   4649 N NE  . ARG   B 1 155 ? -7.62802  25.50180  -25.71150 1.000 31.01076 ? 137  ARG   B NE  1 
ATOM   4650 C CZ  . ARG   B 1 155 ? -8.51024  26.44032  -26.02106 1.000 33.95599 ? 137  ARG   B CZ  1 
ATOM   4651 N NH1 . ARG   B 1 155 ? -9.58975  26.64239  -25.28003 1.000 39.32854 ? 137  ARG   B NH1 1 
ATOM   4652 N NH2 . ARG   B 1 155 ? -8.30529  27.19359  -27.09766 1.000 36.11433 ? 137  ARG   B NH2 1 
ATOM   4653 N N   . ALA   B 1 156 ? -3.84920  21.68964  -25.61267 1.000 14.24258 ? 138  ALA   B N   1 
ATOM   4654 C CA  . ALA   B 1 156 ? -2.77658  21.75497  -26.59842 1.000 18.49719 ? 138  ALA   B CA  1 
ATOM   4655 C C   . ALA   B 1 156 ? -2.72293  23.14115  -27.23990 1.000 14.97616 ? 138  ALA   B C   1 
ATOM   4656 O O   . ALA   B 1 156 ? -3.72027  23.87120  -27.27129 1.000 13.37702 ? 138  ALA   B O   1 
ATOM   4657 C CB  . ALA   B 1 156 ? -2.97178  20.68570  -27.67834 1.000 15.62115 ? 138  ALA   B CB  1 
ATOM   4658 N N   . HIS   B 1 157 ? -1.53041  23.50970  -27.73346 1.000 12.04837 ? 139  HIS   B N   1 
ATOM   4659 C CA  . HIS   B 1 157 ? -1.33416  24.69731  -28.57122 1.000 13.95892 ? 139  HIS   B CA  1 
ATOM   4660 C C   . HIS   B 1 157 ? -1.57737  26.01153  -27.82746 1.000 16.03234 ? 139  HIS   B C   1 
ATOM   4661 O O   . HIS   B 1 157 ? -1.94973  27.01854  -28.43860 1.000 11.81962 ? 139  HIS   B O   1 
ATOM   4662 C CB  . HIS   B 1 157 ? -2.20793  24.63313  -29.83332 1.000 11.45640 ? 139  HIS   B CB  1 
ATOM   4663 C CG  . HIS   B 1 157 ? -2.14595  23.31077  -30.53614 1.000 12.71171 ? 139  HIS   B CG  1 
ATOM   4664 N ND1 . HIS   B 1 157 ? -0.97748  22.81167  -31.07292 1.000 10.30676 ? 139  HIS   B ND1 1 
ATOM   4665 C CD2 . HIS   B 1 157 ? -3.10325  22.38060  -30.78402 1.000 11.13588 ? 139  HIS   B CD2 1 
ATOM   4666 C CE1 . HIS   B 1 157 ? -1.21643  21.63220  -31.62456 1.000 12.96849 ? 139  HIS   B CE1 1 
ATOM   4667 N NE2 . HIS   B 1 157 ? -2.50011  21.34877  -31.46128 1.000 17.50901 ? 139  HIS   B NE2 1 
ATOM   4668 N N   . ILE   B 1 158 ? -1.36783  26.04026  -26.51504 1.000 13.42561 ? 140  ILE   B N   1 
ATOM   4669 C CA  . ILE   B 1 158 ? -1.42802  27.30766  -25.79380 1.000 11.99588 ? 140  ILE   B CA  1 
ATOM   4670 C C   . ILE   B 1 158 ? -0.09512  27.56023  -25.10294 1.000 13.00591 ? 140  ILE   B C   1 
ATOM   4671 O O   . ILE   B 1 158 ? -0.05543  28.02066  -23.96069 1.000 9.84310  ? 140  ILE   B O   1 
ATOM   4672 C CB  . ILE   B 1 158 ? -2.59931  27.34577  -24.78800 1.000 12.59708 ? 140  ILE   B CB  1 
ATOM   4673 C CG1 . ILE   B 1 158 ? -2.51167  26.18768  -23.78828 1.000 15.39140 ? 140  ILE   B CG1 1 
ATOM   4674 C CG2 . ILE   B 1 158 ? -3.94435  27.34643  -25.52579 1.000 12.52139 ? 140  ILE   B CG2 1 
ATOM   4675 C CD1 . ILE   B 1 158 ? -3.40305  26.36867  -22.57572 1.000 13.47077 ? 140  ILE   B CD1 1 
ATOM   4676 N N   . GLN   B 1 159 ? 1.01093   27.27803  -25.79984 1.000 11.89391 ? 141  GLN   B N   1 
ATOM   4677 C CA  . GLN   B 1 159 ? 2.33579   27.38247  -25.20160 1.000 9.23005  ? 141  GLN   B CA  1 
ATOM   4678 C C   . GLN   B 1 159 ? 3.07599   28.66510  -25.57082 1.000 7.86046  ? 141  GLN   B C   1 
ATOM   4679 O O   . GLN   B 1 159 ? 4.00620   29.05353  -24.85219 1.000 10.70308 ? 141  GLN   B O   1 
ATOM   4680 C CB  . GLN   B 1 159 ? 3.19452   26.17660  -25.62079 1.000 9.38605  ? 141  GLN   B CB  1 
ATOM   4681 C CG  . GLN   B 1 159 ? 3.67922   26.18779  -27.09758 1.000 9.46725  ? 141  GLN   B CG  1 
ATOM   4682 C CD  . GLN   B 1 159 ? 2.63820   25.68738  -28.09842 1.000 12.22958 ? 141  GLN   B CD  1 
ATOM   4683 O OE1 . GLN   B 1 159 ? 1.51807   26.19669  -28.16048 1.000 13.42438 ? 141  GLN   B OE1 1 
ATOM   4684 N NE2 . GLN   B 1 159 ? 2.99860   24.65678  -28.86782 1.000 12.41088 ? 141  GLN   B NE2 1 
ATOM   4685 N N   . SER   B 1 160 ? 2.67721   29.33173  -26.64894 1.000 11.84405 ? 142  SER   B N   1 
ATOM   4686 C CA  . SER   B 1 160 ? 3.46560   30.36995  -27.29549 1.000 8.90970  ? 142  SER   B CA  1 
ATOM   4687 C C   . SER   B 1 160 ? 2.89816   31.75416  -27.02029 1.000 14.59704 ? 142  SER   B C   1 
ATOM   4688 O O   . SER   B 1 160 ? 1.75942   31.92481  -26.57955 1.000 11.59422 ? 142  SER   B O   1 
ATOM   4689 C CB  . SER   B 1 160 ? 3.51070   30.14288  -28.80398 1.000 7.75641  ? 142  SER   B CB  1 
ATOM   4690 O OG  . SER   B 1 160 ? 2.24193   30.43174  -29.37844 1.000 11.12818 ? 142  SER   B OG  1 
ATOM   4691 N N   . LEU   B 1 161 ? 3.71056   32.76255  -27.32938 1.000 9.45896  ? 143  LEU   B N   1 
ATOM   4692 C CA  . LEU   B 1 161 ? 3.22802   34.13080  -27.21359 1.000 13.30389 ? 143  LEU   B CA  1 
ATOM   4693 C C   . LEU   B 1 161 ? 2.11856   34.43375  -28.21373 1.000 11.80129 ? 143  LEU   B C   1 
ATOM   4694 O O   . LEU   B 1 161 ? 1.35351   35.37439  -27.99118 1.000 13.27114 ? 143  LEU   B O   1 
ATOM   4695 C CB  . LEU   B 1 161 ? 4.38376   35.11747  -27.38280 1.000 10.88767 ? 143  LEU   B CB  1 
ATOM   4696 C CG  . LEU   B 1 161 ? 5.44833   35.02899  -26.28617 1.000 13.97714 ? 143  LEU   B CG  1 
ATOM   4697 C CD1 . LEU   B 1 161 ? 6.42218   36.15733  -26.45292 1.000 22.30580 ? 143  LEU   B CD1 1 
ATOM   4698 C CD2 . LEU   B 1 161 ? 4.83265   35.07510  -24.91103 1.000 21.17405 ? 143  LEU   B CD2 1 
ATOM   4699 N N   . PHE   B 1 162 ? 2.01803   33.67263  -29.30838 1.000 9.43264  ? 144  PHE   B N   1 
ATOM   4700 C CA  . PHE   B 1 162 ? 0.85221   33.81359  -30.18078 1.000 13.42557 ? 144  PHE   B CA  1 
ATOM   4701 C C   . PHE   B 1 162 ? -0.42920  33.47721  -29.42763 1.000 11.31269 ? 144  PHE   B C   1 
ATOM   4702 O O   . PHE   B 1 162 ? -1.42741  34.20164  -29.52737 1.000 13.05860 ? 144  PHE   B O   1 
ATOM   4703 C CB  . PHE   B 1 162 ? 0.98573   32.92725  -31.41954 1.000 12.13535 ? 144  PHE   B CB  1 
ATOM   4704 C CG  . PHE   B 1 162 ? -0.17487  33.04479  -32.37780 1.000 13.39118 ? 144  PHE   B CG  1 
ATOM   4705 C CD1 . PHE   B 1 162 ? -0.23152  34.08284  -33.30191 1.000 13.77002 ? 144  PHE   B CD1 1 
ATOM   4706 C CD2 . PHE   B 1 162 ? -1.22221  32.12314  -32.34367 1.000 14.75332 ? 144  PHE   B CD2 1 
ATOM   4707 C CE1 . PHE   B 1 162 ? -1.30084  34.19245  -34.18421 1.000 11.49462 ? 144  PHE   B CE1 1 
ATOM   4708 C CE2 . PHE   B 1 162 ? -2.30743  32.23306  -33.22163 1.000 18.97739 ? 144  PHE   B CE2 1 
ATOM   4709 C CZ  . PHE   B 1 162 ? -2.34076  33.26611  -34.14425 1.000 18.11910 ? 144  PHE   B CZ  1 
ATOM   4710 N N   . SER   B 1 163 ? -0.41020  32.39147  -28.65374 1.000 11.81973 ? 145  SER   B N   1 
ATOM   4711 C CA  . SER   B 1 163 ? -1.56896  32.04500  -27.83588 1.000 13.00086 ? 145  SER   B CA  1 
ATOM   4712 C C   . SER   B 1 163 ? -1.79718  33.06712  -26.72689 1.000 12.74908 ? 145  SER   B C   1 
ATOM   4713 O O   . SER   B 1 163 ? -2.94600  33.35513  -26.37212 1.000 13.91092 ? 145  SER   B O   1 
ATOM   4714 C CB  . SER   B 1 163 ? -1.39649  30.64007  -27.24742 1.000 13.54822 ? 145  SER   B CB  1 
ATOM   4715 O OG  . SER   B 1 163 ? -2.43823  30.36166  -26.31864 1.000 15.61993 ? 145  SER   B OG  1 
ATOM   4716 N N   . PHE   B 1 164 ? -0.72383  33.61770  -26.15441 1.000 9.70659  ? 146  PHE   B N   1 
ATOM   4717 C CA  . PHE   B 1 164 ? -0.89612  34.65301  -25.13967 1.000 11.23577 ? 146  PHE   B CA  1 
ATOM   4718 C C   . PHE   B 1 164 ? -1.56013  35.89719  -25.72506 1.000 13.90271 ? 146  PHE   B C   1 
ATOM   4719 O O   . PHE   B 1 164 ? -2.50967  36.44544  -25.14603 1.000 12.65061 ? 146  PHE   B O   1 
ATOM   4720 C CB  . PHE   B 1 164 ? 0.44924   35.02157  -24.51276 1.000 12.22944 ? 146  PHE   B CB  1 
ATOM   4721 C CG  . PHE   B 1 164 ? 0.34232   36.11685  -23.48881 1.000 17.29262 ? 146  PHE   B CG  1 
ATOM   4722 C CD1 . PHE   B 1 164 ? -0.24386  35.87068  -22.25386 1.000 15.73854 ? 146  PHE   B CD1 1 
ATOM   4723 C CD2 . PHE   B 1 164 ? 0.79243   37.40141  -23.77569 1.000 14.76775 ? 146  PHE   B CD2 1 
ATOM   4724 C CE1 . PHE   B 1 164 ? -0.36314  36.88005  -21.30875 1.000 17.28242 ? 146  PHE   B CE1 1 
ATOM   4725 C CE2 . PHE   B 1 164 ? 0.68089   38.42231  -22.84053 1.000 18.12100 ? 146  PHE   B CE2 1 
ATOM   4726 C CZ  . PHE   B 1 164 ? 0.10147   38.16019  -21.60102 1.000 18.76687 ? 146  PHE   B CZ  1 
ATOM   4727 N N   . ILE   B 1 165 ? -1.06923  36.35410  -26.87734 1.000 17.68595 ? 147  ILE   B N   1 
ATOM   4728 C CA  . ILE   B 1 165 ? -1.54436  37.60642  -27.46231 1.000 17.91653 ? 147  ILE   B CA  1 
ATOM   4729 C C   . ILE   B 1 165 ? -2.95719  37.45541  -28.00820 1.000 18.76955 ? 147  ILE   B C   1 
ATOM   4730 O O   . ILE   B 1 165 ? -3.82240  38.30928  -27.77120 1.000 19.44130 ? 147  ILE   B O   1 
ATOM   4731 C CB  . ILE   B 1 165 ? -0.57468  38.08560  -28.55726 1.000 23.31004 ? 147  ILE   B CB  1 
ATOM   4732 C CG1 . ILE   B 1 165 ? 0.74270   38.53525  -27.93524 1.000 25.79735 ? 147  ILE   B CG1 1 
ATOM   4733 C CG2 . ILE   B 1 165 ? -1.20323  39.21938  -29.35698 1.000 26.43614 ? 147  ILE   B CG2 1 
ATOM   4734 C CD1 . ILE   B 1 165 ? 0.56068   39.32394  -26.65339 1.000 27.77687 ? 147  ILE   B CD1 1 
ATOM   4735 N N   . THR   B 1 166 ? -3.21469  36.38161  -28.75615 1.000 15.09504 ? 148  THR   B N   1 
ATOM   4736 C CA  . THR   B 1 166 ? -4.49702  36.26655  -29.44494 1.000 16.74947 ? 148  THR   B CA  1 
ATOM   4737 C C   . THR   B 1 166 ? -5.54919  35.50699  -28.65055 1.000 20.49770 ? 148  THR   B C   1 
ATOM   4738 O O   . THR   B 1 166 ? -6.74376  35.63330  -28.96086 1.000 22.75888 ? 148  THR   B O   1 
ATOM   4739 C CB  . THR   B 1 166 ? -4.32391  35.59189  -30.81094 1.000 19.90300 ? 148  THR   B CB  1 
ATOM   4740 O OG1 . THR   B 1 166 ? -3.93335  34.22419  -30.63356 1.000 15.67831 ? 148  THR   B OG1 1 
ATOM   4741 C CG2 . THR   B 1 166 ? -3.26500  36.32233  -31.62559 1.000 19.17293 ? 148  THR   B CG2 1 
ATOM   4742 N N   . GLY   B 1 167 ? -5.15060  34.73375  -27.63925 1.000 15.58440 ? 149  GLY   B N   1 
ATOM   4743 C CA  . GLY   B 1 167 ? -6.10936  33.95285  -26.87838 1.000 16.19169 ? 149  GLY   B CA  1 
ATOM   4744 C C   . GLY   B 1 167 ? -6.06644  34.15595  -25.37795 1.000 14.89963 ? 149  GLY   B C   1 
ATOM   4745 O O   . GLY   B 1 167 ? -6.84225  33.52983  -24.64902 1.000 16.45730 ? 149  GLY   B O   1 
ATOM   4746 N N   . THR   B 1 168 ? -5.18219  35.03963  -24.90521 1.000 11.50218 ? 150  THR   B N   1 
ATOM   4747 C CA  . THR   B 1 168 ? -4.93246  35.25076  -23.47775 1.000 15.04061 ? 150  THR   B CA  1 
ATOM   4748 C C   . THR   B 1 168 ? -4.93666  33.94052  -22.69048 1.000 14.51041 ? 150  THR   B C   1 
ATOM   4749 O O   . THR   B 1 168 ? -5.41252  33.89821  -21.55072 1.000 14.93155 ? 150  THR   B O   1 
ATOM   4750 C CB  . THR   B 1 168 ? -5.93611  36.25480  -22.87684 1.000 17.53814 ? 150  THR   B CB  1 
ATOM   4751 O OG1 . THR   B 1 168 ? -7.26688  35.71570  -22.89301 1.000 18.33103 ? 150  THR   B OG1 1 
ATOM   4752 C CG2 . THR   B 1 168 ? -5.91546  37.55710  -23.67579 1.000 20.69950 ? 150  THR   B CG2 1 
ATOM   4753 N N   . LYS   B 1 169 ? -4.37821  32.87536  -23.28103 1.000 14.68559 ? 151  LYS   B N   1 
ATOM   4754 C CA  . LYS   B 1 169 ? -4.25607  31.57489  -22.63451 1.000 17.53617 ? 151  LYS   B CA  1 
ATOM   4755 C C   . LYS   B 1 169 ? -2.81804  31.07656  -22.71035 1.000 12.49537 ? 151  LYS   B C   1 
ATOM   4756 O O   . LYS   B 1 169 ? -2.17855  31.16691  -23.76422 1.000 13.08161 ? 151  LYS   B O   1 
ATOM   4757 C CB  . LYS   B 1 169 ? -5.17979  30.53912  -23.28966 1.000 14.40176 ? 151  LYS   B CB  1 
ATOM   4758 C CG  . LYS   B 1 169 ? -6.66729  30.82349  -23.12160 1.000 18.44383 ? 151  LYS   B CG  1 
ATOM   4759 C CD  . LYS   B 1 169 ? -7.51911  29.68706  -23.67918 1.000 17.87601 ? 151  LYS   B CD  1 
ATOM   4760 C CE  . LYS   B 1 169 ? -7.98909  30.00335  -25.09681 1.000 31.80392 ? 151  LYS   B CE  1 
ATOM   4761 N NZ  . LYS   B 1 169 ? -8.60462  31.35792  -25.20339 1.000 28.51722 ? 151  LYS   B NZ  1 
ATOM   4762 N N   . LEU   B 1 170 ? -2.31840  30.52707  -21.59901 1.000 10.53476 ? 152  LEU   B N   1 
ATOM   4763 C CA  . LEU   B 1 170 ? -1.00276  29.89409  -21.57507 1.000 12.97747 ? 152  LEU   B CA  1 
ATOM   4764 C C   . LEU   B 1 170 ? -1.03594  28.65545  -20.69231 1.000 8.72921  ? 152  LEU   B C   1 
ATOM   4765 O O   . LEU   B 1 170 ? -1.69314  28.65272  -19.64837 1.000 11.69967 ? 152  LEU   B O   1 
ATOM   4766 C CB  . LEU   B 1 170 ? 0.08088   30.84629  -21.05706 1.000 10.98020 ? 152  LEU   B CB  1 
ATOM   4767 C CG  . LEU   B 1 170 ? 0.54027   31.92553  -22.03179 1.000 9.56200  ? 152  LEU   B CG  1 
ATOM   4768 C CD1 . LEU   B 1 170 ? 1.50730   32.88874  -21.35167 1.000 11.94614 ? 152  LEU   B CD1 1 
ATOM   4769 C CD2 . LEU   B 1 170 ? 1.19427   31.25137  -23.23425 1.000 14.15999 ? 152  LEU   B CD2 1 
ATOM   4770 N N   . ASP   B 1 171 ? -0.32644  27.60603  -21.10761 1.000 11.05162 ? 153  ASP   B N   1 
ATOM   4771 C CA  . ASP   B 1 171 ? -0.12675  26.48734  -20.19746 1.000 11.15711 ? 153  ASP   B CA  1 
ATOM   4772 C C   . ASP   B 1 171 ? 0.90571   26.87471  -19.13235 1.000 9.56969  ? 153  ASP   B C   1 
ATOM   4773 O O   . ASP   B 1 171 ? 1.46160   27.97353  -19.13615 1.000 8.86196  ? 153  ASP   B O   1 
ATOM   4774 C CB  . ASP   B 1 171 ? 0.23728   25.21246  -20.96763 1.000 11.41234 ? 153  ASP   B CB  1 
ATOM   4775 C CG  . ASP   B 1 171 ? 1.46810   25.36015  -21.87400 1.000 8.38789  ? 153  ASP   B CG  1 
ATOM   4776 O OD1 . ASP   B 1 171 ? 2.38716   26.15969  -21.60402 1.000 10.81824 ? 153  ASP   B OD1 1 
ATOM   4777 O OD2 . ASP   B 1 171 ? 1.51631   24.62719  -22.88276 1.000 13.88714 ? 153  ASP   B OD2 1 
ATOM   4778 N N   . SER   B 1 172 ? 1.13827   25.96714  -18.18062 1.000 7.41710  ? 154  SER   B N   1 
ATOM   4779 C CA  . SER   B 1 172 ? 1.86577   26.34156  -16.97447 1.000 9.93688  ? 154  SER   B CA  1 
ATOM   4780 C C   . SER   B 1 172 ? 3.27839   26.83552  -17.30097 1.000 11.47081 ? 154  SER   B C   1 
ATOM   4781 O O   . SER   B 1 172 ? 3.65468   27.95914  -16.93399 1.000 11.13812 ? 154  SER   B O   1 
ATOM   4782 C CB  . SER   B 1 172 ? 1.88791   25.15929  -16.00208 1.000 11.09439 ? 154  SER   B CB  1 
ATOM   4783 O OG  . SER   B 1 172 ? 2.61921   25.49520  -14.84001 1.000 19.02735 ? 154  SER   B OG  1 
ATOM   4784 N N   . SER   B 1 173 ? 4.06902   26.02986  -18.02378 1.000 11.12137 ? 155  SER   B N   1 
ATOM   4785 C CA  . SER   B 1 173 ? 5.40665   26.49157  -18.39616 1.000 12.22870 ? 155  SER   B CA  1 
ATOM   4786 C C   . SER   B 1 173 ? 5.36562   27.61918  -19.42624 1.000 12.14096 ? 155  SER   B C   1 
ATOM   4787 O O   . SER   B 1 173 ? 6.31698   28.40646  -19.49399 1.000 10.50419 ? 155  SER   B O   1 
ATOM   4788 C CB  . SER   B 1 173 ? 6.26522   25.32812  -18.91020 1.000 10.56470 ? 155  SER   B CB  1 
ATOM   4789 O OG  . SER   B 1 173 ? 5.68368   24.69781  -20.04663 1.000 10.83056 ? 155  SER   B OG  1 
ATOM   4790 N N   . GLY   B 1 174 ? 4.27898   27.73400  -20.20815 1.000 11.42159 ? 156  GLY   B N   1 
ATOM   4791 C CA  . GLY   B 1 174 ? 4.15127   28.86288  -21.12076 1.000 12.37696 ? 156  GLY   B CA  1 
ATOM   4792 C C   . GLY   B 1 174 ? 4.09653   30.20037  -20.40169 1.000 12.02264 ? 156  GLY   B C   1 
ATOM   4793 O O   . GLY   B 1 174 ? 4.57286   31.21140  -20.92437 1.000 11.64836 ? 156  GLY   B O   1 
ATOM   4794 N N   . VAL   B 1 175 ? 3.50562   30.22759  -19.20314 1.000 9.70046  ? 157  VAL   B N   1 
ATOM   4795 C CA  . VAL   B 1 175 ? 3.51638   31.43866  -18.38224 1.000 8.13475  ? 157  VAL   B CA  1 
ATOM   4796 C C   . VAL   B 1 175 ? 4.94531   31.83638  -18.04224 1.000 11.54586 ? 157  VAL   B C   1 
ATOM   4797 O O   . VAL   B 1 175 ? 5.33914   32.99952  -18.19719 1.000 12.34511 ? 157  VAL   B O   1 
ATOM   4798 C CB  . VAL   B 1 175 ? 2.67579   31.23455  -17.10982 1.000 12.94788 ? 157  VAL   B CB  1 
ATOM   4799 C CG1 . VAL   B 1 175 ? 2.80936   32.45040  -16.17642 1.000 10.78252 ? 157  VAL   B CG1 1 
ATOM   4800 C CG2 . VAL   B 1 175 ? 1.21637   30.97700  -17.47742 1.000 13.14265 ? 157  VAL   B CG2 1 
ATOM   4801 N N   . ALA   B 1 176 ? 5.74204   30.87589  -17.56772 1.000 11.07020 ? 158  ALA   B N   1 
ATOM   4802 C CA  . ALA   B 1 176 ? 7.12752   31.16674  -17.21936 1.000 11.39364 ? 158  ALA   B CA  1 
ATOM   4803 C C   . ALA   B 1 176 ? 7.91041   31.67563  -18.42205 1.000 13.01480 ? 158  ALA   B C   1 
ATOM   4804 O O   . ALA   B 1 176 ? 8.66106   32.65468  -18.31053 1.000 10.24877 ? 158  ALA   B O   1 
ATOM   4805 C CB  . ALA   B 1 176 ? 7.80256   29.92174  -16.63951 1.000 12.01284 ? 158  ALA   B CB  1 
ATOM   4806 N N   . PHE   B 1 177 ? 7.74402   31.03021  -19.58283 1.000 11.25035 ? 159  PHE   B N   1 
ATOM   4807 C CA  . PHE   B 1 177 ? 8.41647   31.50346  -20.79049 1.000 13.11870 ? 159  PHE   B CA  1 
ATOM   4808 C C   . PHE   B 1 177 ? 7.98005   32.91843  -21.14920 1.000 12.03128 ? 159  PHE   B C   1 
ATOM   4809 O O   . PHE   B 1 177 ? 8.80502   33.75053  -21.54713 1.000 11.41436 ? 159  PHE   B O   1 
ATOM   4810 C CB  . PHE   B 1 177 ? 8.14990   30.56012  -21.97063 1.000 12.07106 ? 159  PHE   B CB  1 
ATOM   4811 C CG  . PHE   B 1 177 ? 8.78547   31.02792  -23.25764 1.000 11.51001 ? 159  PHE   B CG  1 
ATOM   4812 C CD1 . PHE   B 1 177 ? 10.08965  30.67235  -23.56584 1.000 11.57413 ? 159  PHE   B CD1 1 
ATOM   4813 C CD2 . PHE   B 1 177 ? 8.09264   31.84667  -24.13868 1.000 12.89285 ? 159  PHE   B CD2 1 
ATOM   4814 C CE1 . PHE   B 1 177 ? 10.68641  31.10389  -24.73500 1.000 13.95221 ? 159  PHE   B CE1 1 
ATOM   4815 C CE2 . PHE   B 1 177 ? 8.68314   32.29843  -25.30271 1.000 14.58753 ? 159  PHE   B CE2 1 
ATOM   4816 C CZ  . PHE   B 1 177 ? 9.98293   31.92127  -25.60719 1.000 17.52109 ? 159  PHE   B CZ  1 
ATOM   4817 N N   . ALA   B 1 178 ? 6.68120   33.21141  -21.02850 1.000 12.21080 ? 160  ALA   B N   1 
ATOM   4818 C CA  . ALA   B 1 178 ? 6.20695   34.55156  -21.35171 1.000 12.56742 ? 160  ALA   B CA  1 
ATOM   4819 C C   . ALA   B 1 178 ? 6.79160   35.59911  -20.40467 1.000 10.86129 ? 160  ALA   B C   1 
ATOM   4820 O O   . ALA   B 1 178 ? 7.09669   36.72326  -20.82625 1.000 12.81816 ? 160  ALA   B O   1 
ATOM   4821 C CB  . ALA   B 1 178 ? 4.67589   34.58447  -21.33205 1.000 13.16082 ? 160  ALA   B CB  1 
ATOM   4822 N N   . VAL   B 1 179 ? 6.93530   35.26627  -19.11844 1.000 10.71231 ? 161  VAL   B N   1 
ATOM   4823 C CA  . VAL   B 1 179 ? 7.57713   36.19725  -18.19263 1.000 12.34483 ? 161  VAL   B CA  1 
ATOM   4824 C C   . VAL   B 1 179 ? 9.00642   36.49358  -18.64342 1.000 11.58641 ? 161  VAL   B C   1 
ATOM   4825 O O   . VAL   B 1 179 ? 9.45202   37.64969  -18.62560 1.000 9.16207  ? 161  VAL   B O   1 
ATOM   4826 C CB  . VAL   B 1 179 ? 7.52729   35.65031  -16.75059 1.000 11.40608 ? 161  VAL   B CB  1 
ATOM   4827 C CG1 . VAL   B 1 179 ? 8.33240   36.55868  -15.79169 1.000 10.43193 ? 161  VAL   B CG1 1 
ATOM   4828 C CG2 . VAL   B 1 179 ? 6.07638   35.53279  -16.27981 1.000 10.87745 ? 161  VAL   B CG2 1 
ATOM   4829 N N   . VAL   B 1 180 ? 9.73542   35.46671  -19.09585 1.000 11.69877 ? 162  VAL   B N   1 
ATOM   4830 C CA  . VAL   B 1 180 ? 11.11974  35.69034  -19.51197 1.000 12.20336 ? 162  VAL   B CA  1 
ATOM   4831 C C   . VAL   B 1 180 ? 11.16090  36.51945  -20.79346 1.000 13.20108 ? 162  VAL   B C   1 
ATOM   4832 O O   . VAL   B 1 180 ? 12.00424  37.41275  -20.94573 1.000 15.25134 ? 162  VAL   B O   1 
ATOM   4833 C CB  . VAL   B 1 180 ? 11.86605  34.35053  -19.67692 1.000 10.79258 ? 162  VAL   B CB  1 
ATOM   4834 C CG1 . VAL   B 1 180 ? 13.28576  34.60077  -20.19561 1.000 11.14092 ? 162  VAL   B CG1 1 
ATOM   4835 C CG2 . VAL   B 1 180 ? 11.91301  33.58313  -18.35410 1.000 12.97843 ? 162  VAL   B CG2 1 
ATOM   4836 N N   . GLY   B 1 181 ? 10.25599  36.23647  -21.73184 1.000 10.99395 ? 163  GLY   B N   1 
ATOM   4837 C CA  . GLY   B 1 181 ? 10.17478  37.04316  -22.94265 1.000 14.43203 ? 163  GLY   B CA  1 
ATOM   4838 C C   . GLY   B 1 181 ? 9.82000   38.49053  -22.66302 1.000 16.31913 ? 163  GLY   B C   1 
ATOM   4839 O O   . GLY   B 1 181 ? 10.36539  39.41029  -23.28731 1.000 11.57480 ? 163  GLY   B O   1 
ATOM   4840 N N   . ALA   B 1 182 ? 8.89634   38.71338  -21.72703 1.000 10.88630 ? 164  ALA   B N   1 
ATOM   4841 C CA  . ALA   B 1 182 ? 8.57699   40.07417  -21.31548 1.000 11.45534 ? 164  ALA   B CA  1 
ATOM   4842 C C   . ALA   B 1 182 ? 9.78463   40.75126  -20.67903 1.000 14.68095 ? 164  ALA   B C   1 
ATOM   4843 O O   . ALA   B 1 182 ? 10.07289  41.92189  -20.96252 1.000 12.99561 ? 164  ALA   B O   1 
ATOM   4844 C CB  . ALA   B 1 182 ? 7.39031   40.06157  -20.35239 1.000 14.04722 ? 164  ALA   B CB  1 
ATOM   4845 N N   . CYS   B 1 183 ? 10.51759  40.02800  -19.82916 1.000 9.01314  ? 165  CYS   B N   1 
ATOM   4846 C CA  . CYS   B 1 183 ? 11.71485  40.60576  -19.23003 1.000 15.14868 ? 165  CYS   B CA  1 
ATOM   4847 C C   . CYS   B 1 183 ? 12.74197  40.97997  -20.28976 1.000 14.95772 ? 165  CYS   B C   1 
ATOM   4848 O O   . CYS   B 1 183 ? 13.37152  42.04302  -20.20242 1.000 17.10035 ? 165  CYS   B O   1 
ATOM   4849 C CB  . CYS   B 1 183 ? 12.31093  39.63809  -18.20529 1.000 13.53691 ? 165  CYS   B CB  1 
ATOM   4850 S SG  . CYS   B 1 183 ? 11.33262  39.59051  -16.69926 1.000 16.62211 ? 165  CYS   B SG  1 
ATOM   4851 N N   . GLN   B 1 184 ? 12.92678  40.12930  -21.30286 1.000 17.60940 ? 166  GLN   B N   1 
ATOM   4852 C CA  . GLN   B 1 184 ? 13.84761  40.49481  -22.37545 1.000 17.65434 ? 166  GLN   B CA  1 
ATOM   4853 C C   . GLN   B 1 184 ? 13.36348  41.73890  -23.10873 1.000 17.05779 ? 166  GLN   B C   1 
ATOM   4854 O O   . GLN   B 1 184 ? 14.15593  42.63445  -23.41778 1.000 15.84156 ? 166  GLN   B O   1 
ATOM   4855 C CB  . GLN   B 1 184 ? 14.03470  39.34792  -23.36704 1.000 15.75830 ? 166  GLN   B CB  1 
ATOM   4856 C CG  . GLN   B 1 184 ? 14.92677  39.75357  -24.54795 1.000 19.97437 ? 166  GLN   B CG  1 
ATOM   4857 C CD  . GLN   B 1 184 ? 15.00528  38.70846  -25.64877 1.000 20.15206 ? 166  GLN   B CD  1 
ATOM   4858 O OE1 . GLN   B 1 184 ? 13.98334  38.20429  -26.12627 1.000 11.54419 ? 166  GLN   B OE1 1 
ATOM   4859 N NE2 . GLN   B 1 184 ? 16.22708  38.40646  -26.08652 1.000 14.29699 ? 166  GLN   B NE2 1 
ATOM   4860 N N   . ALA   B 1 185 ? 12.06219  41.81579  -23.38678 1.000 15.68900 ? 167  ALA   B N   1 
ATOM   4861 C CA  . ALA   B 1 185 ? 11.51842  42.98122  -24.07293 1.000 20.48697 ? 167  ALA   B CA  1 
ATOM   4862 C C   . ALA   B 1 185 ? 11.74513  44.26472  -23.27629 1.000 23.70123 ? 167  ALA   B C   1 
ATOM   4863 O O   . ALA   B 1 185 ? 11.83324  45.34871  -23.86238 1.000 19.99358 ? 167  ALA   B O   1 
ATOM   4864 C CB  . ALA   B 1 185 ? 10.02969  42.77276  -24.34356 1.000 12.91613 ? 167  ALA   B CB  1 
ATOM   4865 N N   . LEU   B 1 186 ? 11.83991  44.16530  -21.94997 1.000 17.00071 ? 168  LEU   B N   1 
ATOM   4866 C CA  . LEU   B 1 186 ? 12.17309  45.29395  -21.08784 1.000 19.36764 ? 168  LEU   B CA  1 
ATOM   4867 C C   . LEU   B 1 186 ? 13.67391  45.49133  -20.91917 1.000 29.14579 ? 168  LEU   B C   1 
ATOM   4868 O O   . LEU   B 1 186 ? 14.08615  46.43301  -20.23414 1.000 26.16450 ? 168  LEU   B O   1 
ATOM   4869 C CB  . LEU   B 1 186 ? 11.53828  45.11165  -19.70486 1.000 16.02449 ? 168  LEU   B CB  1 
ATOM   4870 C CG  . LEU   B 1 186 ? 10.01645  45.16253  -19.68759 1.000 12.87985 ? 168  LEU   B CG  1 
ATOM   4871 C CD1 . LEU   B 1 186 ? 9.47076   44.65842  -18.35717 1.000 20.58755 ? 168  LEU   B CD1 1 
ATOM   4872 C CD2 . LEU   B 1 186 ? 9.51561   46.57945  -19.97340 1.000 20.30672 ? 168  LEU   B CD2 1 
ATOM   4873 N N   . GLY   B 1 187 ? 14.49413  44.62688  -21.50880 1.000 20.58296 ? 169  GLY   B N   1 
ATOM   4874 C CA  . GLY   B 1 187 ? 15.92932  44.73970  -21.37133 1.000 20.83355 ? 169  GLY   B CA  1 
ATOM   4875 C C   . GLY   B 1 187 ? 16.47678  44.19535  -20.07736 1.000 29.60693 ? 169  GLY   B C   1 
ATOM   4876 O O   . GLY   B 1 187 ? 17.55292  44.61466  -19.65217 1.000 23.91667 ? 169  GLY   B O   1 
ATOM   4877 N N   . LEU   B 1 188 ? 15.77010  43.27074  -19.42563 1.000 20.56231 ? 170  LEU   B N   1 
ATOM   4878 C CA  . LEU   B 1 188 ? 16.25172  42.70081  -18.16842 1.000 23.29424 ? 170  LEU   B CA  1 
ATOM   4879 C C   . LEU   B 1 188 ? 17.04349  41.43674  -18.49571 1.000 28.63382 ? 170  LEU   B C   1 
ATOM   4880 O O   . LEU   B 1 188 ? 16.55157  40.31139  -18.39502 1.000 20.84774 ? 170  LEU   B O   1 
ATOM   4881 C CB  . LEU   B 1 188 ? 15.08590  42.41958  -17.23257 1.000 17.42710 ? 170  LEU   B CB  1 
ATOM   4882 C CG  . LEU   B 1 188 ? 14.07174  43.55168  -17.08142 1.000 20.95151 ? 170  LEU   B CG  1 
ATOM   4883 C CD1 . LEU   B 1 188 ? 12.95982  43.14017  -16.12497 1.000 18.06129 ? 170  LEU   B CD1 1 
ATOM   4884 C CD2 . LEU   B 1 188 ? 14.76628  44.82532  -16.59051 1.000 21.84998 ? 170  LEU   B CD2 1 
ATOM   4885 N N   . ARG   B 1 189 ? 18.31173  41.63867  -18.87469 1.000 22.13076 ? 171  ARG   B N   1 
ATOM   4886 C CA  . ARG   B 1 189 ? 19.12920  40.56257  -19.43106 1.000 25.28851 ? 171  ARG   B CA  1 
ATOM   4887 C C   . ARG   B 1 189 ? 19.45251  39.45736  -18.43467 1.000 18.03140 ? 171  ARG   B C   1 
ATOM   4888 O O   . ARG   B 1 189 ? 19.89035  38.38326  -18.86000 1.000 22.12797 ? 171  ARG   B O   1 
ATOM   4889 C CB  . ARG   B 1 189 ? 20.43610  41.12613  -19.99439 1.000 28.33084 ? 171  ARG   B CB  1 
ATOM   4890 C CG  . ARG   B 1 189 ? 20.26526  41.82546  -21.32466 1.000 35.52488 ? 171  ARG   B CG  1 
ATOM   4891 C CD  . ARG   B 1 189 ? 21.31713  42.89964  -21.55824 1.000 40.28648 ? 171  ARG   B CD  1 
ATOM   4892 N NE  . ARG   B 1 189 ? 20.86221  43.83348  -22.58264 1.000 61.35047 ? 171  ARG   B NE  1 
ATOM   4893 C CZ  . ARG   B 1 189 ? 20.34167  45.02949  -22.33363 1.000 56.45318 ? 171  ARG   B CZ  1 
ATOM   4894 N NH1 . ARG   B 1 189 ? 20.21346  45.48709  -21.09626 1.000 48.33504 ? 171  ARG   B NH1 1 
ATOM   4895 N NH2 . ARG   B 1 189 ? 19.92782  45.78100  -23.35051 1.000 62.08657 ? 171  ARG   B NH2 1 
ATOM   4896 N N   . ASP   B 1 190 ? 19.26657  39.68639  -17.13433 1.000 22.04906 ? 172  ASP   B N   1 
ATOM   4897 C CA  . ASP   B 1 190 ? 19.61794  38.68919  -16.12720 1.000 18.86830 ? 172  ASP   B CA  1 
ATOM   4898 C C   . ASP   B 1 190 ? 18.48087  37.72431  -15.79119 1.000 19.62662 ? 172  ASP   B C   1 
ATOM   4899 O O   . ASP   B 1 190 ? 18.70667  36.76473  -15.03991 1.000 16.84071 ? 172  ASP   B O   1 
ATOM   4900 C CB  . ASP   B 1 190 ? 20.09170  39.38004  -14.84257 1.000 18.95390 ? 172  ASP   B CB  1 
ATOM   4901 C CG  . ASP   B 1 190 ? 19.00126  40.22639  -14.19910 1.000 35.61086 ? 172  ASP   B CG  1 
ATOM   4902 O OD1 . ASP   B 1 190 ? 18.37739  41.03076  -14.93154 1.000 24.21419 ? 172  ASP   B OD1 1 
ATOM   4903 O OD2 . ASP   B 1 190 ? 18.75977  40.08191  -12.97423 1.000 28.35055 ? 172  ASP   B OD2 1 
ATOM   4904 N N   . VAL   B 1 191 ? 17.27810  37.93756  -16.31165 1.000 18.08347 ? 173  VAL   B N   1 
ATOM   4905 C CA  . VAL   B 1 191 ? 16.14670  37.06786  -15.99270 1.000 11.85397 ? 173  VAL   B CA  1 
ATOM   4906 C C   . VAL   B 1 191 ? 16.10478  35.93608  -17.00402 1.000 14.53911 ? 173  VAL   B C   1 
ATOM   4907 O O   . VAL   B 1 191 ? 16.04846  36.17556  -18.21853 1.000 11.36740 ? 173  VAL   B O   1 
ATOM   4908 C CB  . VAL   B 1 191 ? 14.81837  37.84155  -15.99159 1.000 14.26444 ? 173  VAL   B CB  1 
ATOM   4909 C CG1 . VAL   B 1 191 ? 13.68530  36.89921  -15.57306 1.000 12.03827 ? 173  VAL   B CG1 1 
ATOM   4910 C CG2 . VAL   B 1 191 ? 14.89246  39.03541  -15.05833 1.000 18.40683 ? 173  VAL   B CG2 1 
ATOM   4911 N N   . HIS   B 1 192 ? 16.10713  34.70183  -16.50559 1.000 13.29582 ? 174  HIS   B N   1 
ATOM   4912 C CA  . HIS   B 1 192 ? 16.19199  33.54124  -17.37086 1.000 12.05490 ? 174  HIS   B CA  1 
ATOM   4913 C C   . HIS   B 1 192 ? 15.21873  32.46364  -16.93548 1.000 11.88139 ? 174  HIS   B C   1 
ATOM   4914 O O   . HIS   B 1 192 ? 14.75080  32.42750  -15.79402 1.000 12.98233 ? 174  HIS   B O   1 
ATOM   4915 C CB  . HIS   B 1 192 ? 17.61093  32.96901  -17.39695 1.000 10.14060 ? 174  HIS   B CB  1 
ATOM   4916 C CG  . HIS   B 1 192 ? 18.55027  33.79510  -18.20891 1.000 11.15656 ? 174  HIS   B CG  1 
ATOM   4917 N ND1 . HIS   B 1 192 ? 18.45937  33.87930  -19.58285 1.000 15.42558 ? 174  HIS   B ND1 1 
ATOM   4918 C CD2 . HIS   B 1 192 ? 19.56407  34.61140  -17.84520 1.000 15.86926 ? 174  HIS   B CD2 1 
ATOM   4919 C CE1 . HIS   B 1 192 ? 19.39388  34.69707  -20.03208 1.000 17.36739 ? 174  HIS   B CE1 1 
ATOM   4920 N NE2 . HIS   B 1 192 ? 20.08052  35.15274  -18.99882 1.000 15.36172 ? 174  HIS   B NE2 1 
ATOM   4921 N N   . LEU   B 1 193 ? 14.94604  31.57031  -17.87444 1.000 8.14022  ? 175  LEU   B N   1 
ATOM   4922 C CA  . LEU   B 1 193 ? 14.04296  30.45723  -17.64092 1.000 9.90989  ? 175  LEU   B CA  1 
ATOM   4923 C C   . LEU   B 1 193 ? 14.76436  29.36758  -16.86210 1.000 11.09347 ? 175  LEU   B C   1 
ATOM   4924 O O   . LEU   B 1 193 ? 15.87957  28.97171  -17.21554 1.000 8.16821  ? 175  LEU   B O   1 
ATOM   4925 C CB  . LEU   B 1 193 ? 13.53156  29.90622  -18.96905 1.000 7.30790  ? 175  LEU   B CB  1 
ATOM   4926 C CG  . LEU   B 1 193 ? 12.50483  28.76492  -18.91647 1.000 10.57231 ? 175  LEU   B CG  1 
ATOM   4927 C CD1 . LEU   B 1 193 ? 11.18539  29.24014  -18.32762 1.000 9.26124  ? 175  LEU   B CD1 1 
ATOM   4928 C CD2 . LEU   B 1 193 ? 12.28625  28.15159  -20.31355 1.000 8.93949  ? 175  LEU   B CD2 1 
ATOM   4929 N N   . ALA   B 1 194 ? 14.13159  28.89557  -15.79403 1.000 13.83073 ? 176  ALA   B N   1 
ATOM   4930 C CA  . ALA   B 1 194 ? 14.58421  27.72039  -15.06830 1.000 12.12209 ? 176  ALA   B CA  1 
ATOM   4931 C C   . ALA   B 1 194 ? 13.59214  26.60368  -15.34193 1.000 11.50561 ? 176  ALA   B C   1 
ATOM   4932 O O   . ALA   B 1 194 ? 12.37551  26.82822  -15.31720 1.000 11.59718 ? 176  ALA   B O   1 
ATOM   4933 C CB  . ALA   B 1 194 ? 14.70663  27.99851  -13.56620 1.000 7.59302  ? 176  ALA   B CB  1 
ATOM   4934 N N   . LEU   B 1 195 ? 14.10767  25.41657  -15.63726 1.000 9.19675  ? 177  LEU   B N   1 
ATOM   4935 C CA  . LEU   B 1 195 ? 13.26463  24.31786  -16.07846 1.000 9.49594  ? 177  LEU   B CA  1 
ATOM   4936 C C   . LEU   B 1 195 ? 13.69845  23.04744  -15.37065 1.000 11.58184 ? 177  LEU   B C   1 
ATOM   4937 O O   . LEU   B 1 195 ? 14.87438  22.68053  -15.44544 1.000 10.47604 ? 177  LEU   B O   1 
ATOM   4938 C CB  . LEU   B 1 195 ? 13.38258  24.13603  -17.59849 1.000 13.18692 ? 177  LEU   B CB  1 
ATOM   4939 C CG  . LEU   B 1 195 ? 12.26698  23.33779  -18.24798 1.000 21.81053 ? 177  LEU   B CG  1 
ATOM   4940 C CD1 . LEU   B 1 195 ? 11.02858  24.24913  -18.30883 1.000 19.59386 ? 177  LEU   B CD1 1 
ATOM   4941 C CD2 . LEU   B 1 195 ? 12.66655  22.87794  -19.62927 1.000 15.53312 ? 177  LEU   B CD2 1 
ATOM   4942 N N   . SER   B 1 196 ? 12.76465  22.36926  -14.69340 1.000 9.51713  ? 178  SER   B N   1 
ATOM   4943 C CA  . SER   B 1 196 ? 13.03139  20.99421  -14.28513 1.000 11.36012 ? 178  SER   B CA  1 
ATOM   4944 C C   . SER   B 1 196 ? 12.48153  20.05444  -15.35837 1.000 12.93580 ? 178  SER   B C   1 
ATOM   4945 O O   . SER   B 1 196 ? 12.34497  20.43585  -16.52309 1.000 10.64235 ? 178  SER   B O   1 
ATOM   4946 C CB  . SER   B 1 196 ? 12.43101  20.70154  -12.91189 1.000 9.37257  ? 178  SER   B CB  1 
ATOM   4947 O OG  . SER   B 1 196 ? 11.01301  20.80641  -12.92533 1.000 10.90078 ? 178  SER   B OG  1 
ATOM   4948 N N   . GLU   B 1 197 ? 12.17640  18.81489  -14.99707 1.000 10.64636 ? 179  GLU   B N   1 
ATOM   4949 C CA  . GLU   B 1 197 ? 11.56836  17.91424  -15.96487 1.000 10.17623 ? 179  GLU   B CA  1 
ATOM   4950 C C   . GLU   B 1 197 ? 10.05082  18.05023  -16.02671 1.000 9.53591  ? 179  GLU   B C   1 
ATOM   4951 O O   . GLU   B 1 197 ? 9.42980   17.47985  -16.93378 1.000 9.57744  ? 179  GLU   B O   1 
ATOM   4952 C CB  . GLU   B 1 197 ? 11.97041  16.46985  -15.64892 1.000 11.41443 ? 179  GLU   B CB  1 
ATOM   4953 C CG  . GLU   B 1 197 ? 13.45704  16.20576  -15.93707 1.000 10.62013 ? 179  GLU   B CG  1 
ATOM   4954 C CD  . GLU   B 1 197 ? 13.87457  14.74221  -15.74664 1.000 11.98094 ? 179  GLU   B CD  1 
ATOM   4955 O OE1 . GLU   B 1 197 ? 13.57401  14.16001  -14.68313 1.000 13.93391 ? 179  GLU   B OE1 1 
ATOM   4956 O OE2 . GLU   B 1 197 ? 14.50747  14.18026  -16.66594 1.000 10.72746 ? 179  GLU   B OE2 1 
ATOM   4957 N N   . ASP   B 1 198 ? 9.43941   18.80011  -15.10465 1.000 8.00458  ? 180  ASP   B N   1 
ATOM   4958 C CA  . ASP   B 1 198 ? 7.99541   19.01266  -15.17903 1.000 11.12091 ? 180  ASP   B CA  1 
ATOM   4959 C C   . ASP   B 1 198 ? 7.53355   20.38335  -14.69969 1.000 15.05503 ? 180  ASP   B C   1 
ATOM   4960 O O   . ASP   B 1 198 ? 6.32217   20.61661  -14.68308 1.000 13.67050 ? 180  ASP   B O   1 
ATOM   4961 C CB  . ASP   B 1 198 ? 7.26612   17.92196  -14.37473 1.000 13.28371 ? 180  ASP   B CB  1 
ATOM   4962 C CG  . ASP   B 1 198 ? 5.79110   17.83057  -14.70867 1.000 15.53761 ? 180  ASP   B CG  1 
ATOM   4963 O OD1 . ASP   B 1 198 ? 5.44284   17.71363  -15.90360 1.000 14.83904 ? 180  ASP   B OD1 1 
ATOM   4964 O OD2 . ASP   B 1 198 ? 4.97755   17.87417  -13.76595 1.000 20.00716 ? 180  ASP   B OD2 1 
ATOM   4965 N N   . HIS   B 1 199 ? 8.42656   21.29918  -14.32245 1.000 8.22086  ? 181  HIS   B N   1 
ATOM   4966 C CA  . HIS   B 1 199 ? 8.01150   22.59748  -13.79090 1.000 10.10672 ? 181  HIS   B CA  1 
ATOM   4967 C C   . HIS   B 1 199 ? 8.96305   23.67493  -14.30137 1.000 11.55325 ? 181  HIS   B C   1 
ATOM   4968 O O   . HIS   B 1 199 ? 10.09019  23.38668  -14.71446 1.000 10.40093 ? 181  HIS   B O   1 
ATOM   4969 C CB  . HIS   B 1 199 ? 7.96857   22.55771  -12.24542 1.000 9.51893  ? 181  HIS   B CB  1 
ATOM   4970 C CG  . HIS   B 1 199 ? 7.46077   23.81588  -11.60211 1.000 12.67766 ? 181  HIS   B CG  1 
ATOM   4971 N ND1 . HIS   B 1 199 ? 6.33915   24.48581  -12.04663 1.000 10.87822 ? 181  HIS   B ND1 1 
ATOM   4972 C CD2 . HIS   B 1 199 ? 7.92949   24.52769  -10.54518 1.000 10.07982 ? 181  HIS   B CD2 1 
ATOM   4973 C CE1 . HIS   B 1 199 ? 6.13906   25.55524  -11.29334 1.000 13.14294 ? 181  HIS   B CE1 1 
ATOM   4974 N NE2 . HIS   B 1 199 ? 7.08360   25.59866  -10.36944 1.000 10.39060 ? 181  HIS   B NE2 1 
ATOM   4975 N N   . ALA   B 1 200 ? 8.49929   24.92984  -14.28041 1.000 10.40067 ? 182  ALA   B N   1 
ATOM   4976 C CA  . ALA   B 1 200 ? 9.29713   26.04733  -14.76604 1.000 10.61459 ? 182  ALA   B CA  1 
ATOM   4977 C C   . ALA   B 1 200 ? 9.15984   27.24203  -13.82496 1.000 10.69147 ? 182  ALA   B C   1 
ATOM   4978 O O   . ALA   B 1 200 ? 8.11632   27.44953  -13.20077 1.000 9.66377  ? 182  ALA   B O   1 
ATOM   4979 C CB  . ALA   B 1 200 ? 8.88903   26.44251  -16.19350 1.000 11.42945 ? 182  ALA   B CB  1 
ATOM   4980 N N   . TRP   B 1 201 ? 10.22955  28.02385  -13.73052 1.000 11.04581 ? 183  TRP   B N   1 
ATOM   4981 C CA  . TRP   B 1 201 ? 10.23212  29.26273  -12.95578 1.000 11.25282 ? 183  TRP   B CA  1 
ATOM   4982 C C   . TRP   B 1 201 ? 11.29149  30.17385  -13.55715 1.000 12.17044 ? 183  TRP   B C   1 
ATOM   4983 O O   . TRP   B 1 201 ? 11.76308  29.93811  -14.67294 1.000 11.43482 ? 183  TRP   B O   1 
ATOM   4984 C CB  . TRP   B 1 201 ? 10.45122  28.98128  -11.46138 1.000 8.48662  ? 183  TRP   B CB  1 
ATOM   4985 C CG  . TRP   B 1 201 ? 11.71418  28.21860  -11.09851 1.000 9.93995  ? 183  TRP   B CG  1 
ATOM   4986 C CD1 . TRP   B 1 201 ? 12.89152  28.75332  -10.62695 1.000 11.06882 ? 183  TRP   B CD1 1 
ATOM   4987 C CD2 . TRP   B 1 201 ? 11.90554  26.78930  -11.11377 1.000 7.71147  ? 183  TRP   B CD2 1 
ATOM   4988 N NE1 . TRP   B 1 201 ? 13.80638  27.74759  -10.37374 1.000 8.42321  ? 183  TRP   B NE1 1 
ATOM   4989 C CE2 . TRP   B 1 201 ? 13.22340  26.53799  -10.65725 1.000 8.35511  ? 183  TRP   B CE2 1 
ATOM   4990 C CE3 . TRP   B 1 201 ? 11.09603  25.70389  -11.47716 1.000 9.10922  ? 183  TRP   B CE3 1 
ATOM   4991 C CZ2 . TRP   B 1 201 ? 13.75190  25.24414  -10.55913 1.000 10.99809 ? 183  TRP   B CZ2 1 
ATOM   4992 C CZ3 . TRP   B 1 201 ? 11.62031  24.41497  -11.37702 1.000 13.02660 ? 183  TRP   B CZ3 1 
ATOM   4993 C CH2 . TRP   B 1 201 ? 12.93764  24.19827  -10.91839 1.000 9.47882  ? 183  TRP   B CH2 1 
ATOM   4994 N N   . VAL   B 1 202 ? 11.67189  31.22671  -12.83129 1.000 9.88246  ? 184  VAL   B N   1 
ATOM   4995 C CA  . VAL   B 1 202 ? 12.70763  32.11323  -13.33821 1.000 11.18767 ? 184  VAL   B CA  1 
ATOM   4996 C C   . VAL   B 1 202 ? 13.87004  32.18922  -12.35786 1.000 9.52560  ? 184  VAL   B C   1 
ATOM   4997 O O   . VAL   B 1 202 ? 13.71660  32.06418  -11.13785 1.000 9.63393  ? 184  VAL   B O   1 
ATOM   4998 C CB  . VAL   B 1 202 ? 12.17390  33.52792  -13.66885 1.000 15.55505 ? 184  VAL   B CB  1 
ATOM   4999 C CG1 . VAL   B 1 202 ? 10.93746  33.43101  -14.56840 1.000 13.29763 ? 184  VAL   B CG1 1 
ATOM   5000 C CG2 . VAL   B 1 202 ? 11.88744  34.31290  -12.40399 1.000 15.83559 ? 184  VAL   B CG2 1 
ATOM   5001 N N   . VAL   B 1 203 ? 15.05429  32.36703  -12.92136 1.000 11.91179 ? 185  VAL   B N   1 
ATOM   5002 C CA  . VAL   B 1 203 ? 16.25909  32.67343  -12.16305 1.000 13.05454 ? 185  VAL   B CA  1 
ATOM   5003 C C   . VAL   B 1 203 ? 16.72186  34.05605  -12.58503 1.000 18.56446 ? 185  VAL   B C   1 
ATOM   5004 O O   . VAL   B 1 203 ? 16.45420  34.50368  -13.70563 1.000 18.40011 ? 185  VAL   B O   1 
ATOM   5005 C CB  . VAL   B 1 203 ? 17.37949  31.63620  -12.38183 1.000 18.80469 ? 185  VAL   B CB  1 
ATOM   5006 C CG1 . VAL   B 1 203 ? 17.01831  30.32440  -11.71586 1.000 23.36406 ? 185  VAL   B CG1 1 
ATOM   5007 C CG2 . VAL   B 1 203 ? 17.63672  31.43626  -13.86632 1.000 15.19522 ? 185  VAL   B CG2 1 
ATOM   5008 N N   . PHE   B 1 204 ? 17.41001  34.73936  -11.68360 1.000 15.35316 ? 186  PHE   B N   1 
ATOM   5009 C CA  . PHE   B 1 204 ? 17.83409  36.11162  -11.94985 1.000 16.13982 ? 186  PHE   B CA  1 
ATOM   5010 C C   . PHE   B 1 204 ? 18.89203  36.48272  -10.91738 1.000 22.09352 ? 186  PHE   B C   1 
ATOM   5011 O O   . PHE   B 1 204 ? 19.35786  35.63455  -10.14498 1.000 16.26331 ? 186  PHE   B O   1 
ATOM   5012 C CB  . PHE   B 1 204 ? 16.64132  37.07156  -11.92390 1.000 12.42726 ? 186  PHE   B CB  1 
ATOM   5013 C CG  . PHE   B 1 204 ? 15.92515  37.11464  -10.59791 1.000 14.39520 ? 186  PHE   B CG  1 
ATOM   5014 C CD1 . PHE   B 1 204 ? 15.04474  36.10478  -10.22821 1.000 14.48616 ? 186  PHE   B CD1 1 
ATOM   5015 C CD2 . PHE   B 1 204 ? 16.11718  38.17015  -9.73316  1.000 16.26427 ? 186  PHE   B CD2 1 
ATOM   5016 C CE1 . PHE   B 1 204 ? 14.38911  36.14471  -9.01587  1.000 13.07214 ? 186  PHE   B CE1 1 
ATOM   5017 C CE2 . PHE   B 1 204 ? 15.46044  38.21938  -8.51967  1.000 15.92248 ? 186  PHE   B CE2 1 
ATOM   5018 C CZ  . PHE   B 1 204 ? 14.59773  37.20611  -8.16057  1.000 26.23447 ? 186  PHE   B CZ  1 
ATOM   5019 N N   . GLY   B 1 205 ? 19.27712  37.75418  -10.90993 1.000 21.52837 ? 187  GLY   B N   1 
ATOM   5020 C CA  . GLY   B 1 205 ? 20.23742  38.23758  -9.95228  1.000 24.60562 ? 187  GLY   B CA  1 
ATOM   5021 C C   . GLY   B 1 205 ? 21.66080  38.11031  -10.44802 1.000 26.84227 ? 187  GLY   B C   1 
ATOM   5022 O O   . GLY   B 1 205 ? 21.93477  37.54313  -11.51320 1.000 28.61270 ? 187  GLY   B O   1 
ATOM   5023 N N   . PRO   B 1 206 ? 22.60145  38.60148  -9.63640  1.000 38.69612 ? 188  PRO   B N   1 
ATOM   5024 C CA  . PRO   B 1 206 ? 23.97878  38.79743  -10.12986 1.000 39.19773 ? 188  PRO   B CA  1 
ATOM   5025 C C   . PRO   B 1 206 ? 24.61928  37.54263  -10.69995 1.000 41.83097 ? 188  PRO   B C   1 
ATOM   5026 O O   . PRO   B 1 206 ? 25.28924  37.62582  -11.73711 1.000 51.89646 ? 188  PRO   B O   1 
ATOM   5027 C CB  . PRO   B 1 206 ? 24.73870  39.30853  -8.89648  1.000 42.54209 ? 188  PRO   B CB  1 
ATOM   5028 C CG  . PRO   B 1 206 ? 23.74142  39.49981  -7.81036  1.000 48.99180 ? 188  PRO   B CG  1 
ATOM   5029 C CD  . PRO   B 1 206 ? 22.42556  38.93222  -8.21253  1.000 38.49484 ? 188  PRO   B CD  1 
ATOM   5030 N N   . ASN   B 1 207 ? 24.44008  36.38206  -10.06115 1.000 37.65858 ? 189  ASN   B N   1 
ATOM   5031 C CA  . ASN   B 1 207 ? 24.98042  35.12521  -10.57744 1.000 31.98310 ? 189  ASN   B CA  1 
ATOM   5032 C C   . ASN   B 1 207 ? 23.88450  34.13487  -10.94535 1.000 33.75286 ? 189  ASN   B C   1 
ATOM   5033 O O   . ASN   B 1 207 ? 24.13232  32.92456  -10.96928 1.000 37.22382 ? 189  ASN   B O   1 
ATOM   5034 C CB  . ASN   B 1 207 ? 25.94803  34.48027  -9.57891  1.000 38.08240 ? 189  ASN   B CB  1 
ATOM   5035 C CG  . ASN   B 1 207 ? 26.82809  35.49391  -8.86522  1.000 51.09749 ? 189  ASN   B CG  1 
ATOM   5036 O OD1 . ASN   B 1 207 ? 26.82216  35.58558  -7.63604  1.000 46.94248 ? 189  ASN   B OD1 1 
ATOM   5037 N ND2 . ASN   B 1 207 ? 27.60574  36.24773  -9.63674  1.000 45.45648 ? 189  ASN   B ND2 1 
ATOM   5038 N N   . GLY   B 1 208 ? 22.68194  34.61904  -11.24644 1.000 30.25595 ? 190  GLY   B N   1 
ATOM   5039 C CA  . GLY   B 1 208 ? 21.58418  33.71345  -11.51507 1.000 25.52656 ? 190  GLY   B CA  1 
ATOM   5040 C C   . GLY   B 1 208 ? 21.20602  32.84212  -10.34008 1.000 25.96279 ? 190  GLY   B C   1 
ATOM   5041 O O   . GLY   B 1 208 ? 20.63424  31.76531  -10.53299 1.000 31.23553 ? 190  GLY   B O   1 
ATOM   5042 N N   . GLU   B 1 209 ? 21.50343  33.28064  -9.11631  1.000 21.94991 ? 191  GLU   B N   1 
ATOM   5043 C CA  . GLU   B 1 209 ? 21.27316  32.46297  -7.93575  1.000 24.39287 ? 191  GLU   B CA  1 
ATOM   5044 C C   . GLU   B 1 209 ? 19.97102  32.79377  -7.21643  1.000 23.28674 ? 191  GLU   B C   1 
ATOM   5045 O O   . GLU   B 1 209 ? 19.61521  32.09450  -6.26144  1.000 27.63685 ? 191  GLU   B O   1 
ATOM   5046 C CB  . GLU   B 1 209 ? 22.45605  32.60272  -6.97493  1.000 26.40037 ? 191  GLU   B CB  1 
ATOM   5047 C CG  . GLU   B 1 209 ? 23.77990  32.26496  -7.65724  1.000 45.21518 ? 191  GLU   B CG  1 
ATOM   5048 C CD  . GLU   B 1 209 ? 24.73016  31.47800  -6.77884  1.000 45.62692 ? 191  GLU   B CD  1 
ATOM   5049 O OE1 . GLU   B 1 209 ? 24.87777  31.83275  -5.58908  1.000 48.12890 ? 191  GLU   B OE1 1 
ATOM   5050 O OE2 . GLU   B 1 209 ? 25.33494  30.50846  -7.28739  1.000 54.99849 ? 191  GLU   B OE2 1 
ATOM   5051 N N   . GLN   B 1 210 ? 19.25163  33.82426  -7.64920  1.000 12.69202 ? 192  GLN   B N   1 
ATOM   5052 C CA  . GLN   B 1 210 ? 17.92223  34.10536  -7.12264  1.000 11.26200 ? 192  GLN   B CA  1 
ATOM   5053 C C   . GLN   B 1 210 ? 16.86896  33.37771  -7.94915  1.000 14.95383 ? 192  GLN   B C   1 
ATOM   5054 O O   . GLN   B 1 210 ? 17.01559  33.21660  -9.16287  1.000 12.33061 ? 192  GLN   B O   1 
ATOM   5055 C CB  . GLN   B 1 210 ? 17.64833  35.61286  -7.10728  1.000 15.02075 ? 192  GLN   B CB  1 
ATOM   5056 C CG  . GLN   B 1 210 ? 18.75599  36.42505  -6.43384  1.000 20.17559 ? 192  GLN   B CG  1 
ATOM   5057 C CD  . GLN   B 1 210 ? 18.93350  36.08587  -4.95338  1.000 23.05415 ? 192  GLN   B CD  1 
ATOM   5058 O OE1 . GLN   B 1 210 ? 17.96767  36.01987  -4.19127  1.000 24.77240 ? 192  GLN   B OE1 1 
ATOM   5059 N NE2 . GLN   B 1 210 ? 20.17489  35.88442  -4.54178  1.000 28.32874 ? 192  GLN   B NE2 1 
ATOM   5060 N N   . THR   B 1 211 ? 15.81575  32.91426  -7.27762  1.000 12.70780 ? 193  THR   B N   1 
ATOM   5061 C CA  . THR   B 1 211 ? 14.73061  32.19000  -7.92800  1.000 12.47645 ? 193  THR   B CA  1 
ATOM   5062 C C   . THR   B 1 211 ? 13.39320  32.78088  -7.51396  1.000 13.18151 ? 193  THR   B C   1 
ATOM   5063 O O   . THR   B 1 211 ? 13.22506  33.26821  -6.39001  1.000 10.78515 ? 193  THR   B O   1 
ATOM   5064 C CB  . THR   B 1 211 ? 14.76416  30.68445  -7.58482  1.000 13.76945 ? 193  THR   B CB  1 
ATOM   5065 O OG1 . THR   B 1 211 ? 14.72201  30.51382  -6.15560  1.000 13.15942 ? 193  THR   B OG1 1 
ATOM   5066 C CG2 . THR   B 1 211 ? 16.03941  30.01618  -8.16288  1.000 10.73745 ? 193  THR   B CG2 1 
ATOM   5067 N N   . ALA   B 1 212 ? 12.43755  32.72860  -8.43499  1.000 10.08115 ? 194  ALA   B N   1 
ATOM   5068 C CA  . ALA   B 1 212 ? 11.08437  33.17294  -8.15460  1.000 14.09767 ? 194  ALA   B CA  1 
ATOM   5069 C C   . ALA   B 1 212 ? 10.10262  32.30048  -8.92422  1.000 7.66300  ? 194  ALA   B C   1 
ATOM   5070 O O   . ALA   B 1 212 ? 10.25307  32.11189  -10.13658 1.000 11.74672 ? 194  ALA   B O   1 
ATOM   5071 C CB  . ALA   B 1 212 ? 10.89486  34.65121  -8.52181  1.000 8.66096  ? 194  ALA   B CB  1 
ATOM   5072 N N   . GLU   B 1 213 ? 9.13322   31.73915  -8.20566  1.000 9.22996  ? 195  GLU   B N   1 
ATOM   5073 C CA  . GLU   B 1 213 ? 7.98290   31.10110  -8.83279  1.000 10.33687 ? 195  GLU   B CA  1 
ATOM   5074 C C   . GLU   B 1 213 ? 7.12655   32.14192  -9.54345  1.000 12.50097 ? 195  GLU   B C   1 
ATOM   5075 O O   . GLU   B 1 213 ? 6.86471   33.22323  -9.00283  1.000 12.72451 ? 195  GLU   B O   1 
ATOM   5076 C CB  . GLU   B 1 213 ? 7.13112   30.37938  -7.78304  1.000 8.65508  ? 195  GLU   B CB  1 
ATOM   5077 C CG  . GLU   B 1 213 ? 7.85578   29.26300  -7.03433  1.000 10.52429 ? 195  GLU   B CG  1 
ATOM   5078 C CD  . GLU   B 1 213 ? 7.72763   27.89930  -7.72323  1.000 15.44616 ? 195  GLU   B CD  1 
ATOM   5079 O OE1 . GLU   B 1 213 ? 7.22338   27.83628  -8.86976  1.000 13.13960 ? 195  GLU   B OE1 1 
ATOM   5080 O OE2 . GLU   B 1 213 ? 8.12206   26.88557  -7.10623  1.000 13.60357 ? 195  GLU   B OE2 1 
ATOM   5081 N N   . VAL   B 1 214 ? 6.66233   31.79729  -10.74825 1.000 12.75348 ? 196  VAL   B N   1 
ATOM   5082 C CA  . VAL   B 1 214 ? 5.88048   32.71651  -11.57187 1.000 11.65562 ? 196  VAL   B CA  1 
ATOM   5083 C C   . VAL   B 1 214 ? 4.63794   32.04277  -12.15392 1.000 10.96181 ? 196  VAL   B C   1 
ATOM   5084 O O   . VAL   B 1 214 ? 3.81267   32.70965  -12.78452 1.000 14.45151 ? 196  VAL   B O   1 
ATOM   5085 C CB  . VAL   B 1 214 ? 6.73405   33.30890  -12.71136 1.000 12.32604 ? 196  VAL   B CB  1 
ATOM   5086 C CG1 . VAL   B 1 214 ? 7.91307   34.15636  -12.17164 1.000 9.29236  ? 196  VAL   B CG1 1 
ATOM   5087 C CG2 . VAL   B 1 214 ? 7.21545   32.19251  -13.62856 1.000 9.41847  ? 196  VAL   B CG2 1 
ATOM   5088 N N   . THR   B 1 215 ? 4.48070   30.72805  -11.97112 1.000 9.99971  ? 197  THR   B N   1 
ATOM   5089 C CA  . THR   B 1 215 ? 3.34297   30.03044  -12.57450 1.000 14.55641 ? 197  THR   B CA  1 
ATOM   5090 C C   . THR   B 1 215 ? 2.82138   28.96169  -11.61086 1.000 16.34004 ? 197  THR   B C   1 
ATOM   5091 O O   . THR   B 1 215 ? 3.32108   28.81015  -10.48999 1.000 18.36482 ? 197  THR   B O   1 
ATOM   5092 C CB  . THR   B 1 215 ? 3.72251   29.45146  -13.95227 1.000 11.00737 ? 197  THR   B CB  1 
ATOM   5093 O OG1 . THR   B 1 215 ? 2.54524   28.98002  -14.62519 1.000 11.18281 ? 197  THR   B OG1 1 
ATOM   5094 C CG2 . THR   B 1 215 ? 4.72341   28.30696  -13.82476 1.000 10.86277 ? 197  THR   B CG2 1 
ATOM   5095 N N   . TRP   B 1 216 ? 1.77878   28.23746  -12.03425 1.000 13.37100 ? 198  TRP   B N   1 
ATOM   5096 C CA  . TRP   B 1 216 ? 1.29062   27.12153  -11.23928 1.000 14.67622 ? 198  TRP   B CA  1 
ATOM   5097 C C   . TRP   B 1 216 ? 2.36642   26.04279  -11.13912 1.000 20.64521 ? 198  TRP   B C   1 
ATOM   5098 O O   . TRP   B 1 216 ? 3.21851   25.90001  -12.01643 1.000 23.72011 ? 198  TRP   B O   1 
ATOM   5099 C CB  . TRP   B 1 216 ? 0.05429   26.47365  -11.86406 1.000 15.83146 ? 198  TRP   B CB  1 
ATOM   5100 C CG  . TRP   B 1 216 ? -1.10001  27.34934  -12.17008 1.000 18.04309 ? 198  TRP   B CG  1 
ATOM   5101 C CD1 . TRP   B 1 216 ? -2.09288  27.73721  -11.31070 1.000 20.07644 ? 198  TRP   B CD1 1 
ATOM   5102 C CD2 . TRP   B 1 216 ? -1.44621  27.88772  -13.45418 1.000 19.65349 ? 198  TRP   B CD2 1 
ATOM   5103 N NE1 . TRP   B 1 216 ? -3.02355  28.51092  -11.97901 1.000 18.08740 ? 198  TRP   B NE1 1 
ATOM   5104 C CE2 . TRP   B 1 216 ? -2.64936  28.61733  -13.29421 1.000 19.80718 ? 198  TRP   B CE2 1 
ATOM   5105 C CE3 . TRP   B 1 216 ? -0.85114  27.83364  -14.72223 1.000 19.56525 ? 198  TRP   B CE3 1 
ATOM   5106 C CZ2 . TRP   B 1 216 ? -3.26333  29.29451  -14.35602 1.000 20.11559 ? 198  TRP   B CZ2 1 
ATOM   5107 C CZ3 . TRP   B 1 216 ? -1.46399  28.51668  -15.78202 1.000 18.37491 ? 198  TRP   B CZ3 1 
ATOM   5108 C CH2 . TRP   B 1 216 ? -2.65593  29.23090  -15.58769 1.000 27.31675 ? 198  TRP   B CH2 1 
ATOM   5109 N N   . HIS   B 1 217 ? 2.29471   25.23628  -10.08131 1.000 23.26030 ? 199  HIS   B N   1 
ATOM   5110 C CA  . HIS   B 1 217 ? 3.23460   24.12912  -9.95866  1.000 22.33874 ? 199  HIS   B CA  1 
ATOM   5111 C C   . HIS   B 1 217 ? 2.62105   22.76756  -10.25394 1.000 33.83638 ? 199  HIS   B C   1 
ATOM   5112 O O   . HIS   B 1 217 ? 3.36226   21.83368  -10.58366 1.000 38.41271 ? 199  HIS   B O   1 
ATOM   5113 C CB  . HIS   B 1 217 ? 3.86138   24.10292  -8.55638  1.000 33.52769 ? 199  HIS   B CB  1 
ATOM   5114 C CG  . HIS   B 1 217 ? 2.85978   24.11439  -7.44788  1.000 32.29621 ? 199  HIS   B CG  1 
ATOM   5115 N ND1 . HIS   B 1 217 ? 2.55896   25.25327  -6.73061  1.000 29.28074 ? 199  HIS   B ND1 1 
ATOM   5116 C CD2 . HIS   B 1 217 ? 2.09119   23.12633  -6.92933  1.000 31.94679 ? 199  HIS   B CD2 1 
ATOM   5117 C CE1 . HIS   B 1 217 ? 1.64311   24.96730  -5.82032  1.000 36.65765 ? 199  HIS   B CE1 1 
ATOM   5118 N NE2 . HIS   B 1 217 ? 1.34302   23.68335  -5.91904  1.000 36.63938 ? 199  HIS   B NE2 1 
ATOM   5119 N N   . GLY   B 1 218 ? 1.30407   22.62671  -10.15470 1.000 32.42727 ? 200  GLY   B N   1 
ATOM   5120 C CA  . GLY   B 1 218 ? 0.68940   21.33721  -10.38512 1.000 29.89756 ? 200  GLY   B CA  1 
ATOM   5121 C C   . GLY   B 1 218 ? -0.43564  21.37585  -11.39379 1.000 39.58824 ? 200  GLY   B C   1 
ATOM   5122 O O   . GLY   B 1 218 ? -0.59831  22.35980  -12.12608 1.000 42.02294 ? 200  GLY   B O   1 
ATOM   5123 N N   . LYS   B 1 219 ? -1.21762  20.29800  -11.44229 1.000 29.25528 ? 201  LYS   B N   1 
ATOM   5124 C CA  . LYS   B 1 219 ? -2.34485  20.21297  -12.35798 1.000 35.99384 ? 201  LYS   B CA  1 
ATOM   5125 C C   . LYS   B 1 219 ? -3.55735  20.98268  -11.85968 1.000 38.81692 ? 201  LYS   B C   1 
ATOM   5126 O O   . LYS   B 1 219 ? -4.49346  21.20222  -12.63695 1.000 40.09755 ? 201  LYS   B O   1 
ATOM   5127 C CB  . LYS   B 1 219 ? -2.72266  18.74140  -12.59772 1.000 40.02737 ? 201  LYS   B CB  1 
ATOM   5128 C CG  . LYS   B 1 219 ? -1.54371  17.78320  -12.82961 1.000 40.78207 ? 201  LYS   B CG  1 
ATOM   5129 C CD  . LYS   B 1 219 ? -0.54594  18.26866  -13.88426 1.000 52.10833 ? 201  LYS   B CD  1 
ATOM   5130 C CE  . LYS   B 1 219 ? -1.22959  18.62184  -15.21364 1.000 54.61119 ? 201  LYS   B CE  1 
ATOM   5131 N NZ  . LYS   B 1 219 ? -0.24986  19.03006  -16.26836 1.000 43.30706 ? 201  LYS   B NZ  1 
ATOM   5132 N N   . GLY   B 1 220 ? -3.56792  21.38282  -10.59041 1.000 28.96227 ? 202  GLY   B N   1 
ATOM   5133 C CA  . GLY   B 1 220 ? -4.61786  22.21508  -10.04577 1.000 27.80251 ? 202  GLY   B CA  1 
ATOM   5134 C C   . GLY   B 1 220 ? -4.29511  23.68245  -10.22025 1.000 32.46064 ? 202  GLY   B C   1 
ATOM   5135 O O   . GLY   B 1 220 ? -3.50093  24.07440  -11.07858 1.000 26.28464 ? 202  GLY   B O   1 
ATOM   5136 N N   . ASN   B 1 221 ? -4.90704  24.50553  -9.37152  1.000 20.29897 ? 203  ASN   B N   1 
ATOM   5137 C CA  . ASN   B 1 221 ? -4.80515  25.95420  -9.49585  1.000 18.93597 ? 203  ASN   B CA  1 
ATOM   5138 C C   . ASN   B 1 221 ? -3.99432  26.57911  -8.37310  1.000 22.86572 ? 203  ASN   B C   1 
ATOM   5139 O O   . ASN   B 1 221 ? -4.00301  27.80542  -8.22338  1.000 27.91849 ? 203  ASN   B O   1 
ATOM   5140 C CB  . ASN   B 1 221 ? -6.20124  26.57524  -9.56628  1.000 27.72148 ? 203  ASN   B CB  1 
ATOM   5141 C CG  . ASN   B 1 221 ? -6.93553  26.17830  -10.82620 1.000 25.80709 ? 203  ASN   B CG  1 
ATOM   5142 O OD1 . ASN   B 1 221 ? -6.45698  26.43280  -11.93415 1.000 24.89969 ? 203  ASN   B OD1 1 
ATOM   5143 N ND2 . ASN   B 1 221 ? -8.08363  25.52425  -10.67160 1.000 26.48104 ? 203  ASN   B ND2 1 
ATOM   5144 N N   . GLU   B 1 222 ? -3.27393  25.76673  -7.60492  1.000 22.33593 ? 204  GLU   B N   1 
ATOM   5145 C CA  . GLU   B 1 222 ? -2.41100  26.27726  -6.55381  1.000 25.64786 ? 204  GLU   B CA  1 
ATOM   5146 C C   . GLU   B 1 222 ? -1.17243  26.93980  -7.15819  1.000 20.76255 ? 204  GLU   B C   1 
ATOM   5147 O O   . GLU   B 1 222 ? -0.73154  26.60157  -8.26166  1.000 20.39531 ? 204  GLU   B O   1 
ATOM   5148 C CB  . GLU   B 1 222 ? -1.99164  25.14044  -5.61659  1.000 31.42554 ? 204  GLU   B CB  1 
ATOM   5149 C CG  . GLU   B 1 222 ? -3.14118  24.44284  -4.87758  1.000 37.40987 ? 204  GLU   B CG  1 
ATOM   5150 C CD  . GLU   B 1 222 ? -4.28314  25.38234  -4.50960  1.000 63.76260 ? 204  GLU   B CD  1 
ATOM   5151 O OE1 . GLU   B 1 222 ? -4.03234  26.37698  -3.78981  1.000 63.20731 ? 204  GLU   B OE1 1 
ATOM   5152 O OE2 . GLU   B 1 222 ? -5.43690  25.11400  -4.92241  1.000 69.01878 ? 204  GLU   B OE2 1 
ATOM   5153 N N   . ASP   B 1 223 ? -0.61001  27.89784  -6.42847  1.000 24.48399 ? 205  ASP   B N   1 
ATOM   5154 C CA  . ASP   B 1 223 ? 0.63721   28.50835  -6.86863  1.000 22.66178 ? 205  ASP   B CA  1 
ATOM   5155 C C   . ASP   B 1 223 ? 1.40056   29.03023  -5.65958  1.000 28.96868 ? 205  ASP   B C   1 
ATOM   5156 O O   . ASP   B 1 223 ? 0.81517   29.35220  -4.61932  1.000 22.19992 ? 205  ASP   B O   1 
ATOM   5157 C CB  . ASP   B 1 223 ? 0.40023   29.63544  -7.89040  1.000 18.00482 ? 205  ASP   B CB  1 
ATOM   5158 C CG  . ASP   B 1 223 ? -0.07073  30.92519  -7.24902  1.000 19.02439 ? 205  ASP   B CG  1 
ATOM   5159 O OD1 . ASP   B 1 223 ? 0.76913   31.64936  -6.67058  1.000 24.53494 ? 205  ASP   B OD1 1 
ATOM   5160 O OD2 . ASP   B 1 223 ? -1.27561  31.22980  -7.33473  1.000 20.97159 ? 205  ASP   B OD2 1 
ATOM   5161 N N   . ARG   B 1 224 ? 2.72214   29.09446  -5.81218  1.000 16.95213 ? 206  ARG   B N   1 
ATOM   5162 C CA  . ARG   B 1 224 ? 3.61768   29.67074  -4.82080  1.000 14.96801 ? 206  ARG   B CA  1 
ATOM   5163 C C   . ARG   B 1 224 ? 4.29617   30.91369  -5.38811  1.000 13.53660 ? 206  ARG   B C   1 
ATOM   5164 O O   . ARG   B 1 224 ? 5.44230   31.21261  -5.04315  1.000 13.36414 ? 206  ARG   B O   1 
ATOM   5165 C CB  . ARG   B 1 224 ? 4.65676   28.63817  -4.38225  1.000 16.16295 ? 206  ARG   B CB  1 
ATOM   5166 C CG  . ARG   B 1 224 ? 4.07876   27.46199  -3.59097  1.000 19.40592 ? 206  ARG   B CG  1 
ATOM   5167 C CD  . ARG   B 1 224 ? 5.18302   26.53945  -3.10091  1.000 24.69224 ? 206  ARG   B CD  1 
ATOM   5168 N NE  . ARG   B 1 224 ? 5.66148   25.63583  -4.14424  1.000 21.97475 ? 206  ARG   B NE  1 
ATOM   5169 C CZ  . ARG   B 1 224 ? 5.16703   24.42426  -4.37616  1.000 38.11128 ? 206  ARG   B CZ  1 
ATOM   5170 N NH1 . ARG   B 1 224 ? 4.18078   23.92749  -3.64564  1.000 22.04175 ? 206  ARG   B NH1 1 
ATOM   5171 N NH2 . ARG   B 1 224 ? 5.67762   23.69099  -5.36349  1.000 26.63741 ? 206  ARG   B NH2 1 
ATOM   5172 N N   . ARG   B 1 225 ? 3.59746   31.63123  -6.27709  1.000 10.82314 ? 207  ARG   B N   1 
ATOM   5173 C CA  . ARG   B 1 225 ? 4.20432   32.73129  -7.02068  1.000 12.96886 ? 207  ARG   B CA  1 
ATOM   5174 C C   . ARG   B 1 225 ? 4.81911   33.76659  -6.08569  1.000 16.10463 ? 207  ARG   B C   1 
ATOM   5175 O O   . ARG   B 1 225 ? 4.23788   34.13014  -5.06042  1.000 14.74446 ? 207  ARG   B O   1 
ATOM   5176 C CB  . ARG   B 1 225 ? 3.16793   33.40015  -7.93191  1.000 13.42874 ? 207  ARG   B CB  1 
ATOM   5177 C CG  . ARG   B 1 225 ? 2.73817   32.52164  -9.11599  1.000 15.69387 ? 207  ARG   B CG  1 
ATOM   5178 C CD  . ARG   B 1 225 ? 1.67779   33.19906  -9.97779  1.000 19.91218 ? 207  ARG   B CD  1 
ATOM   5179 N NE  . ARG   B 1 225 ? 2.16757   34.43372  -10.58201 1.000 14.93401 ? 207  ARG   B NE  1 
ATOM   5180 C CZ  . ARG   B 1 225 ? 1.85723   35.65832  -10.17594 1.000 21.92598 ? 207  ARG   B CZ  1 
ATOM   5181 N NH1 . ARG   B 1 225 ? 1.06379   35.86571  -9.13665  1.000 19.25702 ? 207  ARG   B NH1 1 
ATOM   5182 N NH2 . ARG   B 1 225 ? 2.35278   36.70413  -10.83319 1.000 16.48384 ? 207  ARG   B NH2 1 
ATOM   5183 N N   . GLY   B 1 226 ? 6.00979   34.23818  -6.45518  1.000 11.41275 ? 208  GLY   B N   1 
ATOM   5184 C CA  . GLY   B 1 226 ? 6.78582   35.15132  -5.64424  1.000 16.11337 ? 208  GLY   B CA  1 
ATOM   5185 C C   . GLY   B 1 226 ? 7.78741   34.49338  -4.71710  1.000 12.49221 ? 208  GLY   B C   1 
ATOM   5186 O O   . GLY   B 1 226 ? 8.75891   35.14510  -4.31007  1.000 15.48200 ? 208  GLY   B O   1 
ATOM   5187 N N   . GLN   B 1 227 ? 7.58899   33.22282  -4.37626  1.000 11.25867 ? 209  GLN   B N   1 
ATOM   5188 C CA  . GLN   B 1 227 ? 8.51145   32.53431  -3.48218  1.000 12.03661 ? 209  GLN   B CA  1 
ATOM   5189 C C   . GLN   B 1 227 ? 9.72499   32.00190  -4.24136  1.000 12.91501 ? 209  GLN   B C   1 
ATOM   5190 O O   . GLN   B 1 227 ? 9.72466   31.87442  -5.46983  1.000 10.13054 ? 209  GLN   B O   1 
ATOM   5191 C CB  . GLN   B 1 227 ? 7.79563   31.38363  -2.76688  1.000 12.10225 ? 209  GLN   B CB  1 
ATOM   5192 C CG  . GLN   B 1 227 ? 6.73881   31.84784  -1.76106  1.000 16.30627 ? 209  GLN   B CG  1 
ATOM   5193 C CD  . GLN   B 1 227 ? 5.82552   30.72732  -1.29463  1.000 14.71732 ? 209  GLN   B CD  1 
ATOM   5194 O OE1 . GLN   B 1 227 ? 6.27314   29.60849  -1.03938  1.000 19.03715 ? 209  GLN   B OE1 1 
ATOM   5195 N NE2 . GLN   B 1 227 ? 4.53041   31.02157  -1.20019  1.000 15.00986 ? 209  GLN   B NE2 1 
ATOM   5196 N N   . THR   B 1 228 ? 10.76832  31.67009  -3.48529  1.000 10.05857 ? 210  THR   B N   1 
ATOM   5197 C CA  . THR   B 1 228 ? 11.90976  30.96944  -4.05325  1.000 13.63285 ? 210  THR   B CA  1 
ATOM   5198 C C   . THR   B 1 228 ? 11.54985  29.50347  -4.30292  1.000 16.44382 ? 210  THR   B C   1 
ATOM   5199 O O   . THR   B 1 228 ? 10.44228  29.04744  -4.00142  1.000 9.31957  ? 210  THR   B O   1 
ATOM   5200 C CB  . THR   B 1 228 ? 13.10391  31.05183  -3.10800  1.000 13.20863 ? 210  THR   B CB  1 
ATOM   5201 O OG1 . THR   B 1 228 ? 12.83270  30.21700  -1.97620  1.000 11.07605 ? 210  THR   B OG1 1 
ATOM   5202 C CG2 . THR   B 1 228 ? 13.31911  32.48538  -2.64846  1.000 8.61641  ? 210  THR   B CG2 1 
ATOM   5203 N N   . VAL   B 1 229 ? 12.50903  28.74677  -4.84488  1.000 9.25830  ? 211  VAL   B N   1 
ATOM   5204 C CA  . VAL   B 1 229 ? 12.34891  27.30340  -4.98653  1.000 11.54805 ? 211  VAL   B CA  1 
ATOM   5205 C C   . VAL   B 1 229 ? 13.15728  26.53547  -3.94487  1.000 13.56225 ? 211  VAL   B C   1 
ATOM   5206 O O   . VAL   B 1 229 ? 13.24124  25.30545  -4.01818  1.000 14.20495 ? 211  VAL   B O   1 
ATOM   5207 C CB  . VAL   B 1 229 ? 12.69913  26.82722  -6.40827  1.000 9.79061  ? 211  VAL   B CB  1 
ATOM   5208 C CG1 . VAL   B 1 229 ? 11.80153  27.51018  -7.43383  1.000 7.96254  ? 211  VAL   B CG1 1 
ATOM   5209 C CG2 . VAL   B 1 229 ? 14.18123  27.06725  -6.72822  1.000 8.76646  ? 211  VAL   B CG2 1 
ATOM   5210 N N   . ASN   B 1 230 ? 13.72067  27.22956  -2.95029  1.000 12.72707 ? 212  ASN   B N   1 
ATOM   5211 C CA  . ASN   B 1 230 ? 14.66393  26.58994  -2.03306  1.000 15.52620 ? 212  ASN   B CA  1 
ATOM   5212 C C   . ASN   B 1 230 ? 14.02116  25.44827  -1.25049  1.000 12.19405 ? 212  ASN   B C   1 
ATOM   5213 O O   . ASN   B 1 230 ? 14.68527  24.45174  -0.94317  1.000 13.62108 ? 212  ASN   B O   1 
ATOM   5214 C CB  . ASN   B 1 230 ? 15.25051  27.62672  -1.06915  1.000 11.24234 ? 212  ASN   B CB  1 
ATOM   5215 C CG  . ASN   B 1 230 ? 16.11793  28.65704  -1.77900  1.000 21.55659 ? 212  ASN   B CG  1 
ATOM   5216 O OD1 . ASN   B 1 230 ? 16.84851  28.32576  -2.71373  1.000 21.43957 ? 212  ASN   B OD1 1 
ATOM   5217 N ND2 . ASN   B 1 230 ? 16.04847  29.90680  -1.33131  1.000 18.96436 ? 212  ASN   B ND2 1 
ATOM   5218 N N   . ALA   B 1 231 ? 12.74534  25.58585  -0.89303  1.000 15.27572 ? 213  ALA   B N   1 
ATOM   5219 C CA  . ALA   B 1 231 ? 12.07483  24.52886  -0.13868  1.000 17.97638 ? 213  ALA   B CA  1 
ATOM   5220 C C   . ALA   B 1 231 ? 11.96543  23.25332  -0.96623  1.000 19.73382 ? 213  ALA   B C   1 
ATOM   5221 O O   . ALA   B 1 231 ? 12.26622  22.15538  -0.48346  1.000 13.09088 ? 213  ALA   B O   1 
ATOM   5222 C CB  . ALA   B 1 231 ? 10.68802  24.99488  0.30822   1.000 18.70734 ? 213  ALA   B CB  1 
ATOM   5223 N N   . GLY   B 1 232 ? 11.52917  23.38203  -2.21986  1.000 14.27888 ? 214  GLY   B N   1 
ATOM   5224 C CA  . GLY   B 1 232 ? 11.38501  22.20661  -3.06248  1.000 13.50844 ? 214  GLY   B CA  1 
ATOM   5225 C C   . GLY   B 1 232 ? 12.71393  21.53769  -3.35710  1.000 13.18595 ? 214  GLY   B C   1 
ATOM   5226 O O   . GLY   B 1 232 ? 12.79434  20.30744  -3.43281  1.000 14.53470 ? 214  GLY   B O   1 
ATOM   5227 N N   . VAL   B 1 233 ? 13.76980  22.33605  -3.53664  1.000 10.75314 ? 215  VAL   B N   1 
ATOM   5228 C CA  . VAL   B 1 233 ? 15.11256  21.78213  -3.67297  1.000 13.72543 ? 215  VAL   B CA  1 
ATOM   5229 C C   . VAL   B 1 233 ? 15.47939  20.99015  -2.42477  1.000 15.86375 ? 215  VAL   B C   1 
ATOM   5230 O O   . VAL   B 1 233 ? 15.84528  19.80845  -2.49810  1.000 16.93018 ? 215  VAL   B O   1 
ATOM   5231 C CB  . VAL   B 1 233 ? 16.13010  22.90621  -3.95186  1.000 13.06601 ? 215  VAL   B CB  1 
ATOM   5232 C CG1 . VAL   B 1 233 ? 17.55393  22.36177  -3.93376  1.000 13.68131 ? 215  VAL   B CG1 1 
ATOM   5233 C CG2 . VAL   B 1 233 ? 15.82395  23.57987  -5.30369  1.000 12.71155 ? 215  VAL   B CG2 1 
ATOM   5234 N N   . ALA   B 1 234 ? 15.35202  21.62100  -1.25415  1.000 10.58773 ? 216  ALA   B N   1 
ATOM   5235 C CA  . ALA   B 1 234 ? 15.78795  20.97534  -0.02060  1.000 16.25090 ? 216  ALA   B CA  1 
ATOM   5236 C C   . ALA   B 1 234 ? 14.94013  19.75469  0.33373   1.000 14.65784 ? 216  ALA   B C   1 
ATOM   5237 O O   . ALA   B 1 234 ? 15.46115  18.80007  0.91366   1.000 19.10528 ? 216  ALA   B O   1 
ATOM   5238 C CB  . ALA   B 1 234 ? 15.76908  21.98041  1.12704   1.000 13.13820 ? 216  ALA   B CB  1 
ATOM   5239 N N   . GLU   B 1 235 ? 13.64723  19.76315  0.01394   1.000 18.00202 ? 217  GLU   B N   1 
ATOM   5240 C CA  . GLU   B 1 235 ? 12.77977  18.62044  0.30108   1.000 17.46897 ? 217  GLU   B CA  1 
ATOM   5241 C C   . GLU   B 1 235 ? 12.92970  17.47263  -0.69254  1.000 19.31913 ? 217  GLU   B C   1 
ATOM   5242 O O   . GLU   B 1 235 ? 12.26431  16.43820  -0.52444  1.000 14.08197 ? 217  GLU   B O   1 
ATOM   5243 C CB  . GLU   B 1 235 ? 11.31745  19.05970  0.35474   1.000 17.81566 ? 217  GLU   B CB  1 
ATOM   5244 C CG  . GLU   B 1 235 ? 10.97487  19.89554  1.57318   1.000 33.40225 ? 217  GLU   B CG  1 
ATOM   5245 C CD  . GLU   B 1 235 ? 10.99187  19.05684  2.84814   1.000 40.61051 ? 217  GLU   B CD  1 
ATOM   5246 O OE1 . GLU   B 1 235 ? 9.98282   18.37543  3.13288   1.000 43.14614 ? 217  GLU   B OE1 1 
ATOM   5247 O OE2 . GLU   B 1 235 ? 12.01560  19.08269  3.56829   1.000 53.18359 ? 217  GLU   B OE2 1 
ATOM   5248 N N   . ARG   B 1 236 ? 13.77992  17.62349  -1.70784  1.000 12.55483 ? 218  ARG   B N   1 
ATOM   5249 C CA  . ARG   B 1 236 ? 14.07474  16.54455  -2.65212  1.000 13.27731 ? 218  ARG   B CA  1 
ATOM   5250 C C   . ARG   B 1 236 ? 12.81003  16.11436  -3.40242  1.000 16.52964 ? 218  ARG   B C   1 
ATOM   5251 O O   . ARG   B 1 236 ? 12.58420  14.92631  -3.66039  1.000 11.86481 ? 218  ARG   B O   1 
ATOM   5252 C CB  . ARG   B 1 236 ? 14.73508  15.35259  -1.94876  1.000 13.04412 ? 218  ARG   B CB  1 
ATOM   5253 C CG  . ARG   B 1 236 ? 16.10100  15.66837  -1.34381  1.000 17.16018 ? 218  ARG   B CG  1 
ATOM   5254 C CD  . ARG   B 1 236 ? 16.78454  14.39066  -0.84413  1.000 21.82324 ? 218  ARG   B CD  1 
ATOM   5255 N NE  . ARG   B 1 236 ? 16.32142  14.01460  0.48552   1.000 36.06696 ? 218  ARG   B NE  1 
ATOM   5256 C CZ  . ARG   B 1 236 ? 15.90603  12.79737  0.81902   1.000 51.44279 ? 218  ARG   B CZ  1 
ATOM   5257 N NH1 . ARG   B 1 236 ? 15.84891  11.81668  -0.07055  1.000 31.83017 ? 218  ARG   B NH1 1 
ATOM   5258 N NH2 . ARG   B 1 236 ? 15.52494  12.56022  2.07429   1.000 42.11140 ? 218  ARG   B NH2 1 
ATOM   5259 N N   A SER   B 1 237 ? 11.95345  17.08471  -3.71930  0.505 12.10882 ? 219  SER   B N   1 
ATOM   5260 N N   B SER   B 1 237 ? 11.97667  17.09537  -3.74030  0.495 12.12617 ? 219  SER   B N   1 
ATOM   5261 C CA  A SER   B 1 237 ? 10.84251  16.84041  -4.62858  0.505 15.64501 ? 219  SER   B CA  1 
ATOM   5262 C CA  B SER   B 1 237 ? 10.84456  16.88132  -4.62945  0.495 15.66129 ? 219  SER   B CA  1 
ATOM   5263 C C   A SER   B 1 237 ? 11.36229  16.81300  -6.05997  0.505 14.19221 ? 219  SER   B C   1 
ATOM   5264 C C   B SER   B 1 237 ? 11.34210  16.83737  -6.07166  0.495 14.19814 ? 219  SER   B C   1 
ATOM   5265 O O   A SER   B 1 237 ? 12.17049  17.65872  -6.45950  0.505 13.24869 ? 219  SER   B O   1 
ATOM   5266 O O   B SER   B 1 237 ? 12.12210  17.70142  -6.49072  0.495 13.24124 ? 219  SER   B O   1 
ATOM   5267 C CB  A SER   B 1 237 ? 9.76426   17.91784  -4.48405  0.505 16.56954 ? 219  SER   B CB  1 
ATOM   5268 C CB  B SER   B 1 237 ? 9.82216   18.00360  -4.44783  0.495 16.54168 ? 219  SER   B CB  1 
ATOM   5269 O OG  A SER   B 1 237 ? 8.80698   17.83113  -5.53000  0.505 14.55995 ? 219  SER   B OG  1 
ATOM   5270 O OG  B SER   B 1 237 ? 9.74555   18.39369  -3.08173  0.495 10.19517 ? 219  SER   B OG  1 
ATOM   5271 N N   . TRP   B 1 238 ? 10.89343  15.82871  -6.82823  1.000 11.79565 ? 220  TRP   B N   1 
ATOM   5272 C CA  . TRP   B 1 238 ? 11.35631  15.66344  -8.20506  1.000 11.53781 ? 220  TRP   B CA  1 
ATOM   5273 C C   . TRP   B 1 238 ? 11.10870  16.90678  -9.05645  1.000 9.63667  ? 220  TRP   B C   1 
ATOM   5274 O O   . TRP   B 1 238 ? 11.88126  17.17693  -9.98168  1.000 10.31028 ? 220  TRP   B O   1 
ATOM   5275 C CB  . TRP   B 1 238 ? 10.68336  14.43234  -8.83431  1.000 9.25305  ? 220  TRP   B CB  1 
ATOM   5276 C CG  . TRP   B 1 238 ? 10.86022  14.31648  -10.33607 1.000 10.86154 ? 220  TRP   B CG  1 
ATOM   5277 C CD1 . TRP   B 1 238 ? 12.01372  14.00806  -11.01188 1.000 12.28516 ? 220  TRP   B CD1 1 
ATOM   5278 C CD2 . TRP   B 1 238 ? 9.84900   14.49535  -11.33225 1.000 11.58162 ? 220  TRP   B CD2 1 
ATOM   5279 N NE1 . TRP   B 1 238 ? 11.77729  13.98691  -12.36883 1.000 13.63301 ? 220  TRP   B NE1 1 
ATOM   5280 C CE2 . TRP   B 1 238 ? 10.45740  14.28622  -12.59091 1.000 12.11996 ? 220  TRP   B CE2 1 
ATOM   5281 C CE3 . TRP   B 1 238 ? 8.48603   14.82281  -11.28456 1.000 11.36930 ? 220  TRP   B CE3 1 
ATOM   5282 C CZ2 . TRP   B 1 238 ? 9.75326   14.39605  -13.78744 1.000 9.65216  ? 220  TRP   B CZ2 1 
ATOM   5283 C CZ3 . TRP   B 1 238 ? 7.79029   14.93307  -12.47130 1.000 18.96002 ? 220  TRP   B CZ3 1 
ATOM   5284 C CH2 . TRP   B 1 238 ? 8.42188   14.71634  -13.70943 1.000 15.09866 ? 220  TRP   B CH2 1 
ATOM   5285 N N   . LEU   B 1 239 ? 10.04985  17.67533  -8.76435  1.000 14.57909 ? 221  LEU   B N   1 
ATOM   5286 C CA  . LEU   B 1 239 ? 9.78851   18.91677  -9.49931  1.000 13.02411 ? 221  LEU   B CA  1 
ATOM   5287 C C   . LEU   B 1 239 ? 10.93930  19.91288  -9.45430  1.000 9.52534  ? 221  LEU   B C   1 
ATOM   5288 O O   . LEU   B 1 239 ? 11.00509  20.79008  -10.31963 1.000 13.70235 ? 221  LEU   B O   1 
ATOM   5289 C CB  . LEU   B 1 239 ? 8.52223   19.61130  -8.98657  1.000 12.58650 ? 221  LEU   B CB  1 
ATOM   5290 C CG  . LEU   B 1 239 ? 7.28763   19.51696  -9.89431  1.000 20.43859 ? 221  LEU   B CG  1 
ATOM   5291 C CD1 . LEU   B 1 239 ? 6.96308   18.10528  -10.31909 1.000 21.01658 ? 221  LEU   B CD1 1 
ATOM   5292 C CD2 . LEU   B 1 239 ? 6.09648   20.18675  -9.22581  1.000 19.74488 ? 221  LEU   B CD2 1 
ATOM   5293 N N   . TYR   B 1 240 ? 11.82494  19.82338  -8.47129  1.000 10.75192 ? 222  TYR   B N   1 
ATOM   5294 C CA  . TYR   B 1 240 ? 12.94153  20.74915  -8.36127  1.000 9.86858  ? 222  TYR   B CA  1 
ATOM   5295 C C   . TYR   B 1 240 ? 14.30028  20.07520  -8.51856  1.000 11.42949 ? 222  TYR   B C   1 
ATOM   5296 O O   . TYR   B 1 240 ? 15.32443  20.75145  -8.38692  1.000 13.32155 ? 222  TYR   B O   1 
ATOM   5297 C CB  . TYR   B 1 240 ? 12.84320  21.51558  -7.02790  1.000 10.45995 ? 222  TYR   B CB  1 
ATOM   5298 C CG  . TYR   B 1 240 ? 11.54277  22.30327  -6.97533  1.000 7.94082  ? 222  TYR   B CG  1 
ATOM   5299 C CD1 . TYR   B 1 240 ? 11.44297  23.56577  -7.55690  1.000 10.04682 ? 222  TYR   B CD1 1 
ATOM   5300 C CD2 . TYR   B 1 240 ? 10.39422  21.74907  -6.41124  1.000 9.59980  ? 222  TYR   B CD2 1 
ATOM   5301 C CE1 . TYR   B 1 240 ? 10.23453  24.27551  -7.54091  1.000 9.29521  ? 222  TYR   B CE1 1 
ATOM   5302 C CE2 . TYR   B 1 240 ? 9.18420   22.44628  -6.40022  1.000 10.33522 ? 222  TYR   B CE2 1 
ATOM   5303 C CZ  . TYR   B 1 240 ? 9.11388   23.70882  -6.96038  1.000 10.83857 ? 222  TYR   B CZ  1 
ATOM   5304 O OH  . TYR   B 1 240 ? 7.90761   24.39060  -6.93701  1.000 10.08018 ? 222  TYR   B OH  1 
ATOM   5305 N N   . LEU   B 1 241 ? 14.32454  18.76418  -8.79241  1.000 7.96927  ? 223  LEU   B N   1 
ATOM   5306 C CA  . LEU   B 1 241 ? 15.52899  18.01978  -9.19476  1.000 10.95555 ? 223  LEU   B CA  1 
ATOM   5307 C C   . LEU   B 1 241 ? 16.71765  18.21531  -8.24511  1.000 12.07384 ? 223  LEU   B C   1 
ATOM   5308 O O   . LEU   B 1 241 ? 17.87945  18.21716  -8.66745  1.000 11.09116 ? 223  LEU   B O   1 
ATOM   5309 C CB  . LEU   B 1 241 ? 15.93148  18.37727  -10.63109 1.000 11.60326 ? 223  LEU   B CB  1 
ATOM   5310 C CG  . LEU   B 1 241 ? 14.96909  17.97706  -11.75556 1.000 7.74201  ? 223  LEU   B CG  1 
ATOM   5311 C CD1 . LEU   B 1 241 ? 15.41670  18.55931  -13.10189 1.000 10.94180 ? 223  LEU   B CD1 1 
ATOM   5312 C CD2 . LEU   B 1 241 ? 14.85801  16.44702  -11.84650 1.000 11.30744 ? 223  LEU   B CD2 1 
ATOM   5313 N N   . LYS   B 1 242 ? 16.43090  18.35075  -6.94757  1.000 10.44000 ? 224  LYS   B N   1 
ATOM   5314 C CA  . LYS   B 1 242 ? 17.46378  18.58568  -5.92276  1.000 16.21969 ? 224  LYS   B CA  1 
ATOM   5315 C C   . LYS   B 1 242 ? 18.42067  19.71498  -6.31331  1.000 13.18181 ? 224  LYS   B C   1 
ATOM   5316 O O   . LYS   B 1 242 ? 19.60089  19.70711  -5.95152  1.000 12.95899 ? 224  LYS   B O   1 
ATOM   5317 C CB  . LYS   B 1 242 ? 18.23995  17.29705  -5.62309  1.000 10.41143 ? 224  LYS   B CB  1 
ATOM   5318 C CG  . LYS   B 1 242 ? 17.40628  16.25410  -4.89055  1.000 15.21700 ? 224  LYS   B CG  1 
ATOM   5319 C CD  . LYS   B 1 242 ? 18.22978  15.01503  -4.56522  1.000 16.69072 ? 224  LYS   B CD  1 
ATOM   5320 C CE  . LYS   B 1 242 ? 18.25154  14.08577  -5.75449  1.000 14.74478 ? 224  LYS   B CE  1 
ATOM   5321 N NZ  . LYS   B 1 242 ? 19.25367  13.00248  -5.60322  1.000 17.61288 ? 224  LYS   B NZ  1 
ATOM   5322 N N   . GLY   B 1 243 ? 17.91955  20.70236  -7.05429  1.000 12.74722 ? 225  GLY   B N   1 
ATOM   5323 C CA  . GLY   B 1 243 ? 18.74046  21.79889  -7.52304  1.000 16.58891 ? 225  GLY   B CA  1 
ATOM   5324 C C   . GLY   B 1 243 ? 19.50223  21.53792  -8.80790  1.000 13.40401 ? 225  GLY   B C   1 
ATOM   5325 O O   . GLY   B 1 243 ? 20.19534  22.44488  -9.29699  1.000 12.42600 ? 225  GLY   B O   1 
ATOM   5326 N N   . SER   B 1 244 ? 19.41487  20.33828  -9.37067  1.000 10.06594 ? 226  SER   B N   1 
ATOM   5327 C CA  . SER   B 1 244 ? 20.07605  20.06458  -10.64997 1.000 11.06434 ? 226  SER   B CA  1 
ATOM   5328 C C   . SER   B 1 244 ? 19.13213  20.29772  -11.82015 1.000 11.61290 ? 226  SER   B C   1 
ATOM   5329 O O   . SER   B 1 244 ? 18.96019  19.45082  -12.69426 1.000 9.28330  ? 226  SER   B O   1 
ATOM   5330 C CB  . SER   B 1 244 ? 20.62667  18.64421  -10.67078 1.000 15.63356 ? 226  SER   B CB  1 
ATOM   5331 O OG  . SER   B 1 244 ? 21.58798  18.49967  -9.64934  1.000 14.12333 ? 226  SER   B OG  1 
ATOM   5332 N N   . TYR   B 1 245 ? 18.49710  21.45802  -11.82383 1.000 12.41340 ? 227  TYR   B N   1 
ATOM   5333 C CA  . TYR   B 1 245 ? 17.60549  21.84822  -12.89946 1.000 10.73044 ? 227  TYR   B CA  1 
ATOM   5334 C C   . TYR   B 1 245 ? 18.35781  22.71228  -13.89888 1.000 12.74048 ? 227  TYR   B C   1 
ATOM   5335 O O   . TYR   B 1 245 ? 19.46973  23.16930  -13.64982 1.000 12.74297 ? 227  TYR   B O   1 
ATOM   5336 C CB  . TYR   B 1 245 ? 16.38768  22.58313  -12.33959 1.000 13.07927 ? 227  TYR   B CB  1 
ATOM   5337 C CG  . TYR   B 1 245 ? 16.71071  23.80363  -11.50873 1.000 11.74438 ? 227  TYR   B CG  1 
ATOM   5338 C CD1 . TYR   B 1 245 ? 16.94305  25.02997  -12.10662 1.000 13.07030 ? 227  TYR   B CD1 1 
ATOM   5339 C CD2 . TYR   B 1 245 ? 16.75519  23.73037  -10.11744 1.000 10.71969 ? 227  TYR   B CD2 1 
ATOM   5340 C CE1 . TYR   B 1 245 ? 17.23202  26.15362  -11.34715 1.000 15.75686 ? 227  TYR   B CE1 1 
ATOM   5341 C CE2 . TYR   B 1 245 ? 17.03458  24.85123  -9.34612  1.000 15.84586 ? 227  TYR   B CE2 1 
ATOM   5342 C CZ  . TYR   B 1 245 ? 17.27272  26.06109  -9.97248  1.000 13.08106 ? 227  TYR   B CZ  1 
ATOM   5343 O OH  . TYR   B 1 245 ? 17.54512  27.18699  -9.23473  1.000 16.77715 ? 227  TYR   B OH  1 
ATOM   5344 N N   A MET   B 1 246 ? 17.72924  22.91349  -15.05378 0.588 13.15969 ? 228  MET   B N   1 
ATOM   5345 N N   B MET   B 1 246 ? 17.72035  22.97780  -15.02857 0.412 13.16725 ? 228  MET   B N   1 
ATOM   5346 C CA  A MET   B 1 246 ? 18.33108  23.68677  -16.12844 0.588 14.51143 ? 228  MET   B CA  1 
ATOM   5347 C CA  B MET   B 1 246 ? 18.38498  23.65381  -16.13402 0.412 14.47495 ? 228  MET   B CA  1 
ATOM   5348 C C   A MET   B 1 246 ? 18.17377  25.17627  -15.85989 0.588 11.39670 ? 228  MET   B C   1 
ATOM   5349 C C   B MET   B 1 246 ? 18.18129  25.16408  -16.03899 0.412 11.51913 ? 228  MET   B C   1 
ATOM   5350 O O   A MET   B 1 246 ? 17.06456  25.65927  -15.62298 0.588 12.15933 ? 228  MET   B O   1 
ATOM   5351 O O   B MET   B 1 246 ? 17.04680  25.65074  -16.08842 0.412 12.33126 ? 228  MET   B O   1 
ATOM   5352 C CB  A MET   B 1 246 ? 17.68629  23.33483  -17.46893 0.588 12.93616 ? 228  MET   B CB  1 
ATOM   5353 C CB  B MET   B 1 246 ? 17.86393  23.09349  -17.45247 0.412 13.09181 ? 228  MET   B CB  1 
ATOM   5354 C CG  A MET   B 1 246 ? 18.58606  23.60572  -18.65762 0.588 13.17947 ? 228  MET   B CG  1 
ATOM   5355 C CG  B MET   B 1 246 ? 17.94155  21.57461  -17.48078 0.412 16.48541 ? 228  MET   B CG  1 
ATOM   5356 S SD  A MET   B 1 246 ? 17.98481  22.94335  -20.22863 0.588 15.08927 ? 228  MET   B SD  1 
ATOM   5357 S SD  B MET   B 1 246 ? 17.16491  20.85150  -18.92800 0.412 22.38327 ? 228  MET   B SD  1 
ATOM   5358 C CE  A MET   B 1 246 ? 16.45153  22.18099  -19.70953 0.588 19.44219 ? 228  MET   B CE  1 
ATOM   5359 C CE  B MET   B 1 246 ? 17.50954  22.14829  -20.11755 0.412 19.21846 ? 228  MET   B CE  1 
ATOM   5360 N N   . ARG   B 1 247 ? 19.28514  25.89913  -15.89267 1.000 12.95202 ? 229  ARG   B N   1 
ATOM   5361 C CA  . ARG   B 1 247 ? 19.27706  27.35761  -15.86780 1.000 16.66590 ? 229  ARG   B CA  1 
ATOM   5362 C C   . ARG   B 1 247 ? 19.64357  27.80911  -17.27244 1.000 14.46318 ? 229  ARG   B C   1 
ATOM   5363 O O   . ARG   B 1 247 ? 20.77760  27.60188  -17.72378 1.000 11.39012 ? 229  ARG   B O   1 
ATOM   5364 C CB  . ARG   B 1 247 ? 20.23937  27.88845  -14.80844 1.000 19.49895 ? 229  ARG   B CB  1 
ATOM   5365 C CG  . ARG   B 1 247 ? 19.90094  27.33428  -13.43436 1.000 26.76821 ? 229  ARG   B CG  1 
ATOM   5366 C CD  . ARG   B 1 247 ? 21.12421  26.90933  -12.65807 1.000 30.72972 ? 229  ARG   B CD  1 
ATOM   5367 N NE  . ARG   B 1 247 ? 20.84914  26.87849  -11.22611 1.000 23.40385 ? 229  ARG   B NE  1 
ATOM   5368 C CZ  . ARG   B 1 247 ? 20.72022  25.76070  -10.52494 1.000 22.82969 ? 229  ARG   B CZ  1 
ATOM   5369 N NH1 . ARG   B 1 247 ? 20.79930  24.57249  -11.10050 1.000 21.89250 ? 229  ARG   B NH1 1 
ATOM   5370 N NH2 . ARG   B 1 247 ? 20.51255  25.83645  -9.21472  1.000 22.33013 ? 229  ARG   B NH2 1 
ATOM   5371 N N   . CYS   B 1 248 ? 18.67365  28.37768  -17.98453 1.000 10.95212 ? 230  CYS   B N   1 
ATOM   5372 C CA  . CYS   B 1 248 ? 18.86456  28.62382  -19.40849 1.000 11.78728 ? 230  CYS   B CA  1 
ATOM   5373 C C   . CYS   B 1 248 ? 19.61375  29.93031  -19.64508 1.000 11.54599 ? 230  CYS   B C   1 
ATOM   5374 O O   . CYS   B 1 248 ? 19.50158  30.88595  -18.87410 1.000 14.23428 ? 230  CYS   B O   1 
ATOM   5375 C CB  . CYS   B 1 248 ? 17.51931  28.68181  -20.14189 1.000 13.72893 ? 230  CYS   B CB  1 
ATOM   5376 S SG  . CYS   B 1 248 ? 16.52814  27.17482  -20.14187 1.000 15.57352 ? 230  CYS   B SG  1 
ATOM   5377 N N   . ASP   B 1 249 ? 20.40263  29.95259  -20.71512 1.000 12.35432 ? 231  ASP   B N   1 
ATOM   5378 C CA  . ASP   B 1 249 ? 20.76560  31.20321  -21.36132 1.000 16.17665 ? 231  ASP   B CA  1 
ATOM   5379 C C   . ASP   B 1 249 ? 19.74926  31.45551  -22.47871 1.000 15.51551 ? 231  ASP   B C   1 
ATOM   5380 O O   . ASP   B 1 249 ? 18.84878  30.64890  -22.70155 1.000 11.74059 ? 231  ASP   B O   1 
ATOM   5381 C CB  . ASP   B 1 249 ? 22.22367  31.16343  -21.84275 1.000 18.49541 ? 231  ASP   B CB  1 
ATOM   5382 C CG  . ASP   B 1 249 ? 22.48470  30.12348  -22.94108 1.000 18.32634 ? 231  ASP   B CG  1 
ATOM   5383 O OD1 . ASP   B 1 249 ? 21.57551  29.76189  -23.70158 1.000 17.08942 ? 231  ASP   B OD1 1 
ATOM   5384 O OD2 . ASP   B 1 249 ? 23.64044  29.65871  -23.05205 1.000 22.19012 ? 231  ASP   B OD2 1 
ATOM   5385 N N   . ARG   B 1 250 ? 19.88975  32.57733  -23.19497 1.000 13.04495 ? 232  ARG   B N   1 
ATOM   5386 C CA  . ARG   B 1 250 ? 18.89691  32.94532  -24.20925 1.000 12.46293 ? 232  ARG   B CA  1 
ATOM   5387 C C   . ARG   B 1 250 ? 18.78513  31.89895  -25.31630 1.000 13.20819 ? 232  ARG   B C   1 
ATOM   5388 O O   . ARG   B 1 250 ? 17.69694  31.66912  -25.85066 1.000 12.41725 ? 232  ARG   B O   1 
ATOM   5389 C CB  . ARG   B 1 250 ? 19.23956  34.30511  -24.81863 1.000 16.78420 ? 232  ARG   B CB  1 
ATOM   5390 C CG  . ARG   B 1 250 ? 18.93096  35.47785  -23.91623 1.000 18.88815 ? 232  ARG   B CG  1 
ATOM   5391 C CD  . ARG   B 1 250 ? 17.43167  35.78269  -23.87636 1.000 12.84886 ? 232  ARG   B CD  1 
ATOM   5392 N NE  . ARG   B 1 250 ? 17.18457  36.94346  -23.02940 1.000 14.76228 ? 232  ARG   B NE  1 
ATOM   5393 C CZ  . ARG   B 1 250 ? 16.72314  36.89509  -21.78804 1.000 17.37590 ? 232  ARG   B CZ  1 
ATOM   5394 N NH1 . ARG   B 1 250 ? 16.35863  35.75153  -21.22761 1.000 15.42952 ? 232  ARG   B NH1 1 
ATOM   5395 N NH2 . ARG   B 1 250 ? 16.61903  38.02513  -21.09194 1.000 19.80713 ? 232  ARG   B NH2 1 
ATOM   5396 N N   . LYS   B 1 251 ? 19.90055  31.29122  -25.70802 1.000 14.66661 ? 233  LYS   B N   1 
ATOM   5397 C CA  . LYS   B 1 251 ? 19.84201  30.29720  -26.77368 1.000 15.71901 ? 233  LYS   B CA  1 
ATOM   5398 C C   . LYS   B 1 251 ? 19.13745  29.03697  -26.30448 1.000 10.87569 ? 233  LYS   B C   1 
ATOM   5399 O O   . LYS   B 1 251 ? 18.46913  28.36646  -27.09369 1.000 10.13942 ? 233  LYS   B O   1 
ATOM   5400 C CB  . LYS   B 1 251 ? 21.25126  29.95435  -27.25109 1.000 16.90705 ? 233  LYS   B CB  1 
ATOM   5401 C CG  . LYS   B 1 251 ? 22.19623  31.14773  -27.29729 1.000 22.29515 ? 233  LYS   B CG  1 
ATOM   5402 C CD  . LYS   B 1 251 ? 22.20172  31.84115  -28.64254 1.000 24.77795 ? 233  LYS   B CD  1 
ATOM   5403 C CE  . LYS   B 1 251 ? 23.12663  33.05685  -28.58263 1.000 30.27349 ? 233  LYS   B CE  1 
ATOM   5404 N NZ  . LYS   B 1 251 ? 24.07424  33.13201  -29.71349 1.000 30.79763 ? 233  LYS   B NZ  1 
ATOM   5405 N N   . MET   B 1 252 ? 19.31424  28.69462  -25.03311 1.000 10.06859 ? 234  MET   B N   1 
ATOM   5406 C CA  . MET   B 1 252 ? 18.62181  27.57110  -24.42524 1.000 15.96748 ? 234  MET   B CA  1 
ATOM   5407 C C   . MET   B 1 252 ? 17.12720  27.85352  -24.32114 1.000 13.56377 ? 234  MET   B C   1 
ATOM   5408 O O   . MET   B 1 252 ? 16.30812  26.93693  -24.44833 1.000 10.63877 ? 234  MET   B O   1 
ATOM   5409 C CB  . MET   B 1 252 ? 19.26454  27.34942  -23.06302 1.000 16.11806 ? 234  MET   B CB  1 
ATOM   5410 C CG  . MET   B 1 252 ? 20.69838  26.86059  -23.22014 1.000 18.25023 ? 234  MET   B CG  1 
ATOM   5411 S SD  . MET   B 1 252 ? 21.49737  26.42580  -21.68808 1.000 17.24422 ? 234  MET   B SD  1 
ATOM   5412 C CE  . MET   B 1 252 ? 20.54457  25.04686  -21.12709 1.000 14.66016 ? 234  MET   B CE  1 
ATOM   5413 N N   . GLU   B 1 253 ? 16.75455  29.12533  -24.12674 1.000 13.48388 ? 235  GLU   B N   1 
ATOM   5414 C CA  . GLU   B 1 253 ? 15.34460  29.50488  -24.16253 1.000 12.18806 ? 235  GLU   B CA  1 
ATOM   5415 C C   . GLU   B 1 253 ? 14.76411  29.38173  -25.57356 1.000 11.37634 ? 235  GLU   B C   1 
ATOM   5416 O O   . GLU   B 1 253 ? 13.58561  29.03435  -25.72922 1.000 11.96542 ? 235  GLU   B O   1 
ATOM   5417 C CB  . GLU   B 1 253 ? 15.18137  30.91830  -23.58444 1.000 13.50187 ? 235  GLU   B CB  1 
ATOM   5418 C CG  . GLU   B 1 253 ? 15.39726  30.94532  -22.07662 1.000 12.32547 ? 235  GLU   B CG  1 
ATOM   5419 C CD  . GLU   B 1 253 ? 16.00024  32.23280  -21.54826 1.000 12.83199 ? 235  GLU   B CD  1 
ATOM   5420 O OE1 . GLU   B 1 253 ? 16.22424  33.17768  -22.33717 1.000 12.66535 ? 235  GLU   B OE1 1 
ATOM   5421 O OE2 . GLU   B 1 253 ? 16.28785  32.27681  -20.33130 1.000 13.35728 ? 235  GLU   B OE2 1 
ATOM   5422 N N   . VAL   B 1 254 ? 15.57594  29.60489  -26.61143 1.000 10.01419 ? 236  VAL   B N   1 
ATOM   5423 C CA  . VAL   B 1 254 ? 15.13127  29.28492  -27.97122 1.000 9.47717  ? 236  VAL   B CA  1 
ATOM   5424 C C   . VAL   B 1 254 ? 14.92595  27.77800  -28.12194 1.000 13.64920 ? 236  VAL   B C   1 
ATOM   5425 O O   . VAL   B 1 254 ? 13.93029  27.32353  -28.69972 1.000 11.18339 ? 236  VAL   B O   1 
ATOM   5426 C CB  . VAL   B 1 254 ? 16.13458  29.83335  -29.01210 1.000 10.68176 ? 236  VAL   B CB  1 
ATOM   5427 C CG1 . VAL   B 1 254 ? 15.75986  29.37476  -30.41825 1.000 9.56250  ? 236  VAL   B CG1 1 
ATOM   5428 C CG2 . VAL   B 1 254 ? 16.18605  31.35399  -28.95552 1.000 14.24994 ? 236  VAL   B CG2 1 
ATOM   5429 N N   . ALA   B 1 255 ? 15.85645  26.97590  -27.59916 1.000 11.42886 ? 237  ALA   B N   1 
ATOM   5430 C CA  . ALA   B 1 255 ? 15.67225  25.52529  -27.65188 1.000 8.36330  ? 237  ALA   B CA  1 
ATOM   5431 C C   . ALA   B 1 255 ? 14.37683  25.10770  -26.96420 1.000 8.18989  ? 237  ALA   B C   1 
ATOM   5432 O O   . ALA   B 1 255 ? 13.67906  24.20119  -27.43249 1.000 9.16316  ? 237  ALA   B O   1 
ATOM   5433 C CB  . ALA   B 1 255 ? 16.86273  24.81322  -27.01050 1.000 9.43321  ? 237  ALA   B CB  1 
ATOM   5434 N N   . PHE   B 1 256 ? 14.04088  25.75106  -25.84722 1.000 8.13444  ? 238  PHE   B N   1 
ATOM   5435 C CA  . PHE   B 1 256 ? 12.80795  25.39513  -25.15271 1.000 7.98654  ? 238  PHE   B CA  1 
ATOM   5436 C C   . PHE   B 1 256 ? 11.59313  25.61663  -26.04750 1.000 9.39934  ? 238  PHE   B C   1 
ATOM   5437 O O   . PHE   B 1 256 ? 10.74327  24.73062  -26.19987 1.000 9.15470  ? 238  PHE   B O   1 
ATOM   5438 C CB  . PHE   B 1 256 ? 12.68709  26.20189  -23.86041 1.000 7.81402  ? 238  PHE   B CB  1 
ATOM   5439 C CG  . PHE   B 1 256 ? 11.39077  25.98321  -23.13848 1.000 9.73153  ? 238  PHE   B CG  1 
ATOM   5440 C CD1 . PHE   B 1 256 ? 11.21192  24.86371  -22.34831 1.000 9.45441  ? 238  PHE   B CD1 1 
ATOM   5441 C CD2 . PHE   B 1 256 ? 10.34988  26.89741  -23.26145 1.000 8.72603  ? 238  PHE   B CD2 1 
ATOM   5442 C CE1 . PHE   B 1 256 ? 10.01639  24.65548  -21.68137 1.000 12.60132 ? 238  PHE   B CE1 1 
ATOM   5443 C CE2 . PHE   B 1 256 ? 9.15088   26.69136  -22.60297 1.000 12.03093 ? 238  PHE   B CE2 1 
ATOM   5444 C CZ  . PHE   B 1 256 ? 8.98417   25.56870  -21.81494 1.000 13.06727 ? 238  PHE   B CZ  1 
ATOM   5445 N N   . MET   B 1 257 ? 11.49609  26.79297  -26.66305 1.000 10.73424 ? 239  MET   B N   1 
ATOM   5446 C CA  . MET   B 1 257 ? 10.31381  27.06691  -27.47577 1.000 10.01106 ? 239  MET   B CA  1 
ATOM   5447 C C   . MET   B 1 257 ? 10.21469  26.10790  -28.65820 1.000 10.37353 ? 239  MET   B C   1 
ATOM   5448 O O   . MET   B 1 257 ? 9.10608   25.80923  -29.12188 1.000 8.39442  ? 239  MET   B O   1 
ATOM   5449 C CB  . MET   B 1 257 ? 10.32241  28.52826  -27.94762 1.000 14.35418 ? 239  MET   B CB  1 
ATOM   5450 C CG  . MET   B 1 257 ? 11.15371  28.80616  -29.20191 1.000 10.26941 ? 239  MET   B CG  1 
ATOM   5451 S SD  . MET   B 1 257 ? 10.87741  30.49307  -29.79678 1.000 11.90238 ? 239  MET   B SD  1 
ATOM   5452 C CE  . MET   B 1 257 ? 11.79981  31.46888  -28.61669 1.000 8.71974  ? 239  MET   B CE  1 
ATOM   5453 N N   . VAL   B 1 258 ? 11.35109  25.59019  -29.13550 1.000 9.59634  ? 240  VAL   B N   1 
ATOM   5454 C CA  . VAL   B 1 258 ? 11.33675  24.61441  -30.22573 1.000 9.94035  ? 240  VAL   B CA  1 
ATOM   5455 C C   . VAL   B 1 258 ? 10.84471  23.25788  -29.72944 1.000 9.32682  ? 240  VAL   B C   1 
ATOM   5456 O O   . VAL   B 1 258 ? 10.03953  22.59264  -30.39340 1.000 8.56681  ? 240  VAL   B O   1 
ATOM   5457 C CB  . VAL   B 1 258 ? 12.73293  24.51191  -30.87241 1.000 9.85950  ? 240  VAL   B CB  1 
ATOM   5458 C CG1 . VAL   B 1 258 ? 12.77288  23.37089  -31.88848 1.000 8.79260  ? 240  VAL   B CG1 1 
ATOM   5459 C CG2 . VAL   B 1 258 ? 13.12560  25.84115  -31.52868 1.000 8.21631  ? 240  VAL   B CG2 1 
ATOM   5460 N N   . CYS   B 1 259 ? 11.33212  22.81214  -28.56628 1.000 10.82737 ? 241  CYS   B N   1 
ATOM   5461 C CA  . CYS   B 1 259 ? 10.74410  21.63608  -27.93237 1.000 10.46596 ? 241  CYS   B CA  1 
ATOM   5462 C C   . CYS   B 1 259 ? 9.25848   21.83136  -27.68016 1.000 11.88437 ? 241  CYS   B C   1 
ATOM   5463 O O   . CYS   B 1 259 ? 8.48581   20.87139  -27.75032 1.000 10.20226 ? 241  CYS   B O   1 
ATOM   5464 C CB  . CYS   B 1 259 ? 11.46326  21.33407  -26.61447 1.000 8.10308  ? 241  CYS   B CB  1 
ATOM   5465 S SG  . CYS   B 1 259 ? 13.14959  20.72418  -26.84010 1.000 12.96983 ? 241  CYS   B SG  1 
ATOM   5466 N N   . ALA   B 1 260 ? 8.84576   23.07022  -27.39714 1.000 10.08511 ? 242  ALA   B N   1 
ATOM   5467 C CA  . ALA   B 1 260 ? 7.45578   23.37777  -27.08239 1.000 11.52125 ? 242  ALA   B CA  1 
ATOM   5468 C C   . ALA   B 1 260 ? 6.54105   23.29283  -28.29406 1.000 9.79105  ? 242  ALA   B C   1 
ATOM   5469 O O   . ALA   B 1 260 ? 5.32133   23.27155  -28.10982 1.000 11.18823 ? 242  ALA   B O   1 
ATOM   5470 C CB  . ALA   B 1 260 ? 7.35208   24.77033  -26.46187 1.000 7.77669  ? 242  ALA   B CB  1 
ATOM   5471 N N   . ILE   B 1 261 ? 7.08786   23.23490  -29.51490 1.000 9.58434  ? 243  ILE   B N   1 
ATOM   5472 C CA  . ILE   B 1 261 ? 6.24209   23.01771  -30.68513 1.000 10.67403 ? 243  ILE   B CA  1 
ATOM   5473 C C   . ILE   B 1 261 ? 5.43113   21.75160  -30.47042 1.000 12.10763 ? 243  ILE   B C   1 
ATOM   5474 O O   . ILE   B 1 261 ? 5.95419   20.73414  -30.00318 1.000 10.23819 ? 243  ILE   B O   1 
ATOM   5475 C CB  . ILE   B 1 261 ? 7.07665   22.92006  -31.97615 1.000 11.72173 ? 243  ILE   B CB  1 
ATOM   5476 C CG1 . ILE   B 1 261 ? 7.75864   24.25254  -32.28889 1.000 10.31227 ? 243  ILE   B CG1 1 
ATOM   5477 C CG2 . ILE   B 1 261 ? 6.19187   22.48058  -33.17528 1.000 10.71452 ? 243  ILE   B CG2 1 
ATOM   5478 C CD1 . ILE   B 1 261 ? 8.87761   24.10376  -33.33285 1.000 9.60874  ? 243  ILE   B CD1 1 
ATOM   5479 N N   . ASN   B 1 262 ? 4.13855   21.82157  -30.78126 1.000 11.93113 ? 244  ASN   B N   1 
ATOM   5480 C CA  . ASN   B 1 262 ? 3.23758   20.68218  -30.62123 1.000 12.26794 ? 244  ASN   B CA  1 
ATOM   5481 C C   . ASN   B 1 262 ? 2.62194   20.32916  -31.96826 1.000 11.69180 ? 244  ASN   B C   1 
ATOM   5482 O O   . ASN   B 1 262 ? 1.66388   20.99200  -32.41190 1.000 13.14538 ? 244  ASN   B O   1 
ATOM   5483 C CB  . ASN   B 1 262 ? 2.15024   20.98792  -29.59220 1.000 10.93551 ? 244  ASN   B CB  1 
ATOM   5484 C CG  . ASN   B 1 262 ? 1.27696   19.76927  -29.29515 1.000 16.29734 ? 244  ASN   B CG  1 
ATOM   5485 O OD1 . ASN   B 1 262 ? 1.29206   18.78514  -30.03827 1.000 11.60845 ? 244  ASN   B OD1 1 
ATOM   5486 N ND2 . ASN   B 1 262 ? 0.50621   19.84074  -28.21653 1.000 14.29699 ? 244  ASN   B ND2 1 
ATOM   5487 N N   . PRO   B 1 263 ? 3.11974   19.28806  -32.64377 1.000 9.21511  ? 245  PRO   B N   1 
ATOM   5488 C CA  . PRO   B 1 263 ? 2.64005   18.96856  -33.99889 1.000 12.12669 ? 245  PRO   B CA  1 
ATOM   5489 C C   . PRO   B 1 263 ? 1.28513   18.28061  -34.05092 1.000 18.74025 ? 245  PRO   B C   1 
ATOM   5490 O O   . PRO   B 1 263 ? 0.77516   18.05662  -35.15854 1.000 16.52518 ? 245  PRO   B O   1 
ATOM   5491 C CB  . PRO   B 1 263 ? 3.73373   18.03231  -34.54511 1.000 13.04674 ? 245  PRO   B CB  1 
ATOM   5492 C CG  . PRO   B 1 263 ? 4.91089   18.20592  -33.63448 1.000 20.76917 ? 245  PRO   B CG  1 
ATOM   5493 C CD  . PRO   B 1 263 ? 4.31542   18.51110  -32.28486 1.000 13.63486 ? 245  PRO   B CD  1 
ATOM   5494 N N   . SER   B 1 264 ? 0.69174   17.93410  -32.90843 1.000 16.60305 ? 246  SER   B N   1 
ATOM   5495 C CA  . SER   B 1 264 ? -0.55534  17.17428  -32.90205 1.000 15.79528 ? 246  SER   B CA  1 
ATOM   5496 C C   . SER   B 1 264 ? -1.68272  17.97129  -33.54655 1.000 19.24051 ? 246  SER   B C   1 
ATOM   5497 O O   . SER   B 1 264 ? -2.02136  19.06809  -33.09088 1.000 13.91665 ? 246  SER   B O   1 
ATOM   5498 C CB  . SER   B 1 264 ? -0.93903  16.79303  -31.47031 1.000 17.82529 ? 246  SER   B CB  1 
ATOM   5499 O OG  . SER   B 1 264 ? -0.00279  15.88443  -30.92361 1.000 26.77884 ? 246  SER   B OG  1 
ATOM   5500 N N   . ILE   B 1 265 ? -2.25260  17.41937  -34.61549 1.000 15.58917 ? 247  ILE   B N   1 
ATOM   5501 C CA  . ILE   B 1 265 ? -3.45629  17.97277  -35.22824 1.000 19.29206 ? 247  ILE   B CA  1 
ATOM   5502 C C   . ILE   B 1 265 ? -4.71020  17.42419  -34.56386 1.000 19.58122 ? 247  ILE   B C   1 
ATOM   5503 O O   . ILE   B 1 265 ? -5.61873  18.17314  -34.20195 1.000 18.81677 ? 247  ILE   B O   1 
ATOM   5504 C CB  . ILE   B 1 265 ? -3.46729  17.68433  -36.74729 1.000 17.14946 ? 247  ILE   B CB  1 
ATOM   5505 C CG1 . ILE   B 1 265 ? -2.34509  18.43842  -37.46274 1.000 11.47776 ? 247  ILE   B CG1 1 
ATOM   5506 C CG2 . ILE   B 1 265 ? -4.83024  18.00377  -37.34260 1.000 15.41175 ? 247  ILE   B CG2 1 
ATOM   5507 C CD1 . ILE   B 1 265 ? -2.02915  17.83286  -38.82740 1.000 17.65956 ? 247  ILE   B CD1 1 
ATOM   5508 N N   . ASP   B 1 266 ? -4.79598  16.10809  -34.42975 1.000 18.84778 ? 248  ASP   B N   1 
ATOM   5509 C CA  . ASP   B 1 266 ? -5.86609  15.47638  -33.66525 1.000 16.18305 ? 248  ASP   B CA  1 
ATOM   5510 C C   . ASP   B 1 266 ? -5.25047  14.27758  -32.95802 1.000 20.28265 ? 248  ASP   B C   1 
ATOM   5511 O O   . ASP   B 1 266 ? -4.02294  14.16314  -32.86068 1.000 21.28077 ? 248  ASP   B O   1 
ATOM   5512 C CB  . ASP   B 1 266 ? -7.07826  15.12655  -34.55277 1.000 20.56577 ? 248  ASP   B CB  1 
ATOM   5513 C CG  . ASP   B 1 266 ? -6.74001  14.17322  -35.69952 1.000 27.29075 ? 248  ASP   B CG  1 
ATOM   5514 O OD1 . ASP   B 1 266 ? -5.86942  13.29019  -35.55401 1.000 25.06238 ? 248  ASP   B OD1 1 
ATOM   5515 O OD2 . ASP   B 1 266 ? -7.37742  14.30364  -36.76408 1.000 27.05010 ? 248  ASP   B OD2 1 
ATOM   5516 N N   . LEU   B 1 267 ? -6.10693  13.36587  -32.48515 1.000 22.80812 ? 249  LEU   B N   1 
ATOM   5517 C CA  . LEU   B 1 267 ? -5.64292  12.24485  -31.67188 1.000 26.99122 ? 249  LEU   B CA  1 
ATOM   5518 C C   . LEU   B 1 267 ? -4.60812  11.40413  -32.40885 1.000 25.80227 ? 249  LEU   B C   1 
ATOM   5519 O O   . LEU   B 1 267 ? -3.55505  11.07595  -31.85350 1.000 26.87133 ? 249  LEU   B O   1 
ATOM   5520 C CB  . LEU   B 1 267 ? -6.82991  11.37175  -31.26301 1.000 27.83594 ? 249  LEU   B CB  1 
ATOM   5521 C CG  . LEU   B 1 267 ? -6.58177  10.22407  -30.28342 1.000 34.01615 ? 249  LEU   B CG  1 
ATOM   5522 C CD1 . LEU   B 1 267 ? -5.71310  10.67592  -29.11315 1.000 26.57001 ? 249  LEU   B CD1 1 
ATOM   5523 C CD2 . LEU   B 1 267 ? -7.89237  9.59950   -29.81306 1.000 26.91904 ? 249  LEU   B CD2 1 
ATOM   5524 N N   . HIS   B 1 268 ? -4.89080  11.04335  -33.66350 1.000 25.94744 ? 250  HIS   B N   1 
ATOM   5525 C CA  . HIS   B 1 268 ? -4.05571  10.11429  -34.41802 1.000 26.12589 ? 250  HIS   B CA  1 
ATOM   5526 C C   . HIS   B 1 268 ? -3.20598  10.76758  -35.50566 1.000 27.27833 ? 250  HIS   B C   1 
ATOM   5527 O O   . HIS   B 1 268 ? -2.55725  10.04971  -36.27284 1.000 33.70897 ? 250  HIS   B O   1 
ATOM   5528 C CB  . HIS   B 1 268 ? -4.91198  9.02278   -35.06200 1.000 27.88851 ? 250  HIS   B CB  1 
ATOM   5529 C CG  . HIS   B 1 268 ? -5.85340  8.34235   -34.11930 1.000 38.30451 ? 250  HIS   B CG  1 
ATOM   5530 N ND1 . HIS   B 1 268 ? -5.42746  7.71911   -32.96534 1.000 33.98705 ? 250  HIS   B ND1 1 
ATOM   5531 C CD2 . HIS   B 1 268 ? -7.19384  8.15502   -34.17697 1.000 43.01710 ? 250  HIS   B CD2 1 
ATOM   5532 C CE1 . HIS   B 1 268 ? -6.46843  7.19258   -32.34319 1.000 41.52433 ? 250  HIS   B CE1 1 
ATOM   5533 N NE2 . HIS   B 1 268 ? -7.55212  7.44276   -33.05742 1.000 49.74039 ? 250  HIS   B NE2 1 
ATOM   5534 N N   . THR   B 1 269 ? -3.18487  12.09109  -35.61079 1.000 20.24152 ? 251  THR   B N   1 
ATOM   5535 C CA  . THR   B 1 269 ? -2.49899  12.72843  -36.73066 1.000 22.29882 ? 251  THR   B CA  1 
ATOM   5536 C C   . THR   B 1 269 ? -1.61044  13.85363  -36.23641 1.000 20.12038 ? 251  THR   B C   1 
ATOM   5537 O O   . THR   B 1 269 ? -2.08762  14.76457  -35.55248 1.000 16.17593 ? 251  THR   B O   1 
ATOM   5538 C CB  . THR   B 1 269 ? -3.48805  13.28881  -37.75706 1.000 20.77338 ? 251  THR   B CB  1 
ATOM   5539 O OG1 . THR   B 1 269 ? -4.54468  12.34502  -37.98539 1.000 32.04780 ? 251  THR   B OG1 1 
ATOM   5540 C CG2 . THR   B 1 269 ? -2.77589  13.59990  -39.06197 1.000 25.60165 ? 251  THR   B CG2 1 
ATOM   5541 N N   . ASP   B 1 270 ? -0.33189  13.79587  -36.60662 1.000 20.17398 ? 252  ASP   B N   1 
ATOM   5542 C CA  . ASP   B 1 270 ? 0.60495   14.89214  -36.41343 1.000 18.90145 ? 252  ASP   B CA  1 
ATOM   5543 C C   . ASP   B 1 270 ? 0.82878   15.61500  -37.73504 1.000 22.37445 ? 252  ASP   B C   1 
ATOM   5544 O O   . ASP   B 1 270 ? 0.78431   15.01243  -38.81129 1.000 20.03522 ? 252  ASP   B O   1 
ATOM   5545 C CB  . ASP   B 1 270 ? 1.94616   14.39397  -35.87584 1.000 21.45056 ? 252  ASP   B CB  1 
ATOM   5546 C CG  . ASP   B 1 270 ? 1.83240   13.77646  -34.49710 1.000 27.77784 ? 252  ASP   B CG  1 
ATOM   5547 O OD1 . ASP   B 1 270 ? 0.91640   14.15037  -33.73484 1.000 20.49177 ? 252  ASP   B OD1 1 
ATOM   5548 O OD2 . ASP   B 1 270 ? 2.67038   12.91683  -34.17622 1.000 26.72364 ? 252  ASP   B OD2 1 
ATOM   5549 N N   . SER   B 1 271 ? 1.05124   16.91911  -37.64453 1.000 14.89084 ? 253  SER   B N   1 
ATOM   5550 C CA  . SER   B 1 271 ? 1.44054   17.69827  -38.81184 1.000 16.47675 ? 253  SER   B CA  1 
ATOM   5551 C C   . SER   B 1 271 ? 2.86432   17.32768  -39.22236 1.000 16.27018 ? 253  SER   B C   1 
ATOM   5552 O O   . SER   B 1 271 ? 3.81258   17.49926  -38.44694 1.000 12.55425 ? 253  SER   B O   1 
ATOM   5553 C CB  . SER   B 1 271 ? 1.32104   19.19604  -38.50100 1.000 12.40297 ? 253  SER   B CB  1 
ATOM   5554 O OG  . SER   B 1 271 ? 2.15024   19.97611  -39.34367 1.000 16.19259 ? 253  SER   B OG  1 
ATOM   5555 N N   . LEU   B 1 272 ? 3.01383   16.78690  -40.43440 1.000 16.43856 ? 254  LEU   B N   1 
ATOM   5556 C CA  . LEU   B 1 272 ? 4.35198   16.56227  -40.96760 1.000 16.67189 ? 254  LEU   B CA  1 
ATOM   5557 C C   . LEU   B 1 272 ? 5.14695   17.85709  -41.03625 1.000 12.58642 ? 254  LEU   B C   1 
ATOM   5558 O O   . LEU   B 1 272 ? 6.36402   17.85153  -40.82958 1.000 17.64616 ? 254  LEU   B O   1 
ATOM   5559 C CB  . LEU   B 1 272 ? 4.27335   15.92137  -42.35307 1.000 18.33477 ? 254  LEU   B CB  1 
ATOM   5560 C CG  . LEU   B 1 272 ? 3.65010   14.52572  -42.39449 1.000 28.39299 ? 254  LEU   B CG  1 
ATOM   5561 C CD1 . LEU   B 1 272 ? 3.25349   14.14758  -43.82415 1.000 30.37887 ? 254  LEU   B CD1 1 
ATOM   5562 C CD2 . LEU   B 1 272 ? 4.64237   13.53310  -41.81981 1.000 23.58006 ? 254  LEU   B CD2 1 
ATOM   5563 N N   . GLU   B 1 273 ? 4.47882   18.97173  -41.34365 1.000 15.00130 ? 255  GLU   B N   1 
ATOM   5564 C CA  . GLU   B 1 273 ? 5.16536   20.25644  -41.45031 1.000 14.84741 ? 255  GLU   B CA  1 
ATOM   5565 C C   . GLU   B 1 273 ? 5.79527   20.64722  -40.12080 1.000 13.99326 ? 255  GLU   B C   1 
ATOM   5566 O O   . GLU   B 1 273 ? 6.98435   20.99245  -40.05488 1.000 12.47844 ? 255  GLU   B O   1 
ATOM   5567 C CB  . GLU   B 1 273 ? 4.18094   21.33310  -41.91297 1.000 14.33377 ? 255  GLU   B CB  1 
ATOM   5568 C CG  . GLU   B 1 273 ? 3.48811   21.04932  -43.24112 1.000 16.87231 ? 255  GLU   B CG  1 
ATOM   5569 C CD  . GLU   B 1 273 ? 2.14351   20.32858  -43.09259 1.000 16.67137 ? 255  GLU   B CD  1 
ATOM   5570 O OE1 . GLU   B 1 273 ? 1.92186   19.62457  -42.08356 1.000 18.92651 ? 255  GLU   B OE1 1 
ATOM   5571 O OE2 . GLU   B 1 273 ? 1.30348   20.47010  -44.00221 1.000 16.23639 ? 255  GLU   B OE2 1 
ATOM   5572 N N   . LEU   B 1 274 ? 5.01768   20.56244  -39.03949 1.000 8.85099  ? 256  LEU   B N   1 
ATOM   5573 C CA  . LEU   B 1 274 ? 5.51952   20.96972  -37.73079 1.000 12.68281 ? 256  LEU   B CA  1 
ATOM   5574 C C   . LEU   B 1 274 ? 6.57669   20.00252  -37.21816 1.000 16.08437 ? 256  LEU   B C   1 
ATOM   5575 O O   . LEU   B 1 274 ? 7.52345   20.41941  -36.53768 1.000 12.93416 ? 256  LEU   B O   1 
ATOM   5576 C CB  . LEU   B 1 274 ? 4.35477   21.09727  -36.73337 1.000 13.97186 ? 256  LEU   B CB  1 
ATOM   5577 C CG  . LEU   B 1 274 ? 3.42112   22.31493  -36.91256 1.000 18.29945 ? 256  LEU   B CG  1 
ATOM   5578 C CD1 . LEU   B 1 274 ? 2.14795   22.23706  -36.04110 1.000 11.45239 ? 256  LEU   B CD1 1 
ATOM   5579 C CD2 . LEU   B 1 274 ? 4.13674   23.64568  -36.65541 1.000 10.09737 ? 256  LEU   B CD2 1 
ATOM   5580 N N   . LEU   B 1 275 ? 6.43064   18.70713  -37.52006 1.000 11.98133 ? 257  LEU   B N   1 
ATOM   5581 C CA  . LEU   B 1 275 ? 7.48061   17.75671  -37.17342 1.000 12.41460 ? 257  LEU   B CA  1 
ATOM   5582 C C   . LEU   B 1 275 ? 8.78487   18.11945  -37.87335 1.000 13.47446 ? 257  LEU   B C   1 
ATOM   5583 O O   . LEU   B 1 275 ? 9.84703   18.15240  -37.24935 1.000 14.09570 ? 257  LEU   B O   1 
ATOM   5584 C CB  . LEU   B 1 275 ? 7.05184   16.33336  -37.52932 1.000 18.08576 ? 257  LEU   B CB  1 
ATOM   5585 C CG  . LEU   B 1 275 ? 6.02333   15.62335  -36.63323 1.000 17.33281 ? 257  LEU   B CG  1 
ATOM   5586 C CD1 . LEU   B 1 275 ? 5.42233   14.42168  -37.37301 1.000 19.34064 ? 257  LEU   B CD1 1 
ATOM   5587 C CD2 . LEU   B 1 275 ? 6.65403   15.17745  -35.31229 1.000 13.07977 ? 257  LEU   B CD2 1 
ATOM   5588 N N   . GLN   B 1 276 ? 8.72154   18.41891  -39.17334 1.000 16.72115 ? 258  GLN   B N   1 
ATOM   5589 C CA  . GLN   B 1 276 ? 9.95190   18.72574  -39.89738 1.000 17.93295 ? 258  GLN   B CA  1 
ATOM   5590 C C   . GLN   B 1 276 ? 10.54319  20.05547  -39.44345 1.000 17.24168 ? 258  GLN   B C   1 
ATOM   5591 O O   . GLN   B 1 276 ? 11.77206  20.20008  -39.36762 1.000 14.84619 ? 258  GLN   B O   1 
ATOM   5592 C CB  . GLN   B 1 276 ? 9.70221   18.73340  -41.40831 1.000 22.27097 ? 258  GLN   B CB  1 
ATOM   5593 C CG  . GLN   B 1 276 ? 9.04900   17.46352  -42.02181 1.000 32.81587 ? 258  GLN   B CG  1 
ATOM   5594 C CD  . GLN   B 1 276 ? 9.15604   16.16678  -41.18800 1.000 43.58547 ? 258  GLN   B CD  1 
ATOM   5595 O OE1 . GLN   B 1 276 ? 8.16037   15.44206  -41.03452 1.000 21.82544 ? 258  GLN   B OE1 1 
ATOM   5596 N NE2 . GLN   B 1 276 ? 10.37321  15.82065  -40.74906 1.000 36.88830 ? 258  GLN   B NE2 1 
ATOM   5597 N N   . LEU   B 1 277 ? 9.68925   21.04346  -39.14912 1.000 14.46213 ? 259  LEU   B N   1 
ATOM   5598 C CA  . LEU   B 1 277 ? 10.18640  22.31956  -38.64301 1.000 13.72372 ? 259  LEU   B CA  1 
ATOM   5599 C C   . LEU   B 1 277 ? 10.89937  22.13420  -37.30642 1.000 13.13347 ? 259  LEU   B C   1 
ATOM   5600 O O   . LEU   B 1 277 ? 12.02811  22.60268  -37.12116 1.000 12.73249 ? 259  LEU   B O   1 
ATOM   5601 C CB  . LEU   B 1 277 ? 9.03716   23.32585  -38.51533 1.000 13.58791 ? 259  LEU   B CB  1 
ATOM   5602 C CG  . LEU   B 1 277 ? 9.35994   24.68517  -37.87459 1.000 11.65713 ? 259  LEU   B CG  1 
ATOM   5603 C CD1 . LEU   B 1 277 ? 10.44449  25.44368  -38.64652 1.000 12.03090 ? 259  LEU   B CD1 1 
ATOM   5604 C CD2 . LEU   B 1 277 ? 8.10525   25.53628  -37.74643 1.000 11.17535 ? 259  LEU   B CD2 1 
ATOM   5605 N N   . GLN   B 1 278 ? 10.26298  21.42573  -36.36747 1.000 12.23212 ? 260  GLN   B N   1 
ATOM   5606 C CA  . GLN   B 1 278 ? 10.90621  21.15837  -35.08412 1.000 13.45658 ? 260  GLN   B CA  1 
ATOM   5607 C C   . GLN   B 1 278 ? 12.22243  20.40012  -35.26257 1.000 12.63890 ? 260  GLN   B C   1 
ATOM   5608 O O   . GLN   B 1 278 ? 13.22280  20.70907  -34.60352 1.000 14.21373 ? 260  GLN   B O   1 
ATOM   5609 C CB  . GLN   B 1 278 ? 9.95280   20.37294  -34.18388 1.000 10.62005 ? 260  GLN   B CB  1 
ATOM   5610 C CG  . GLN   B 1 278 ? 10.47458  20.15519  -32.76345 1.000 14.96542 ? 260  GLN   B CG  1 
ATOM   5611 C CD  . GLN   B 1 278 ? 9.45247   19.43992  -31.88924 1.000 19.30617 ? 260  GLN   B CD  1 
ATOM   5612 O OE1 . GLN   B 1 278 ? 8.96827   18.36858  -32.24464 1.000 22.22764 ? 260  GLN   B OE1 1 
ATOM   5613 N NE2 . GLN   B 1 278 ? 9.12081   20.03104  -30.74968 1.000 13.13025 ? 260  GLN   B NE2 1 
ATOM   5614 N N   . GLN   B 1 279 ? 12.23269  19.39494  -36.14234 1.000 12.66143 ? 261  GLN   B N   1 
ATOM   5615 C CA  . GLN   B 1 279 ? 13.42788  18.58035  -36.36247 1.000 14.32726 ? 261  GLN   B CA  1 
ATOM   5616 C C   . GLN   B 1 279 ? 14.57671  19.41450  -36.92540 1.000 16.42534 ? 261  GLN   B C   1 
ATOM   5617 O O   . GLN   B 1 279 ? 15.71582  19.32629  -36.44886 1.000 14.41572 ? 261  GLN   B O   1 
ATOM   5618 C CB  . GLN   B 1 279 ? 13.07243  17.42282  -37.30121 1.000 11.34330 ? 261  GLN   B CB  1 
ATOM   5619 C CG  . GLN   B 1 279 ? 14.15289  16.35882  -37.48070 1.000 15.90177 ? 261  GLN   B CG  1 
ATOM   5620 C CD  . GLN   B 1 279 ? 13.60849  15.13900  -38.19977 1.000 26.06856 ? 261  GLN   B CD  1 
ATOM   5621 O OE1 . GLN   B 1 279 ? 12.52747  15.18833  -38.79271 1.000 27.49497 ? 261  GLN   B OE1 1 
ATOM   5622 N NE2 . GLN   B 1 279 ? 14.33487  14.02855  -38.12581 1.000 21.19810 ? 261  GLN   B NE2 1 
ATOM   5623 N N   . LYS   B 1 280 ? 14.29744  20.23630  -37.94285 1.000 15.93493 ? 262  LYS   B N   1 
ATOM   5624 C CA  . LYS   B 1 280 ? 15.34256  21.09152  -38.50401 1.000 16.68879 ? 262  LYS   B CA  1 
ATOM   5625 C C   . LYS   B 1 280 ? 15.81546  22.13000  -37.50030 1.000 17.07074 ? 262  LYS   B C   1 
ATOM   5626 O O   . LYS   B 1 280 ? 17.00903  22.45719  -37.45263 1.000 12.75593 ? 262  LYS   B O   1 
ATOM   5627 C CB  . LYS   B 1 280 ? 14.84887  21.78704  -39.77461 1.000 13.22502 ? 262  LYS   B CB  1 
ATOM   5628 C CG  . LYS   B 1 280 ? 14.62379  20.83926  -40.93348 1.000 19.82444 ? 262  LYS   B CG  1 
ATOM   5629 C CD  . LYS   B 1 280 ? 13.63556  21.43246  -41.91442 1.000 37.23646 ? 262  LYS   B CD  1 
ATOM   5630 C CE  . LYS   B 1 280 ? 14.31680  21.89763  -43.18365 1.000 36.75032 ? 262  LYS   B CE  1 
ATOM   5631 N NZ  . LYS   B 1 280 ? 15.12688  20.82859  -43.80663 1.000 36.58982 ? 262  LYS   B NZ  1 
ATOM   5632 N N   . LEU   B 1 281 ? 14.89579  22.68496  -36.70863 1.000 14.65114 ? 263  LEU   B N   1 
ATOM   5633 C CA  . LEU   B 1 281 ? 15.30286  23.68059  -35.71912 1.000 15.39736 ? 263  LEU   B CA  1 
ATOM   5634 C C   . LEU   B 1 281 ? 16.16933  23.05221  -34.63057 1.000 11.60660 ? 263  LEU   B C   1 
ATOM   5635 O O   . LEU   B 1 281 ? 17.14474  23.66464  -34.17459 1.000 11.85453 ? 263  LEU   B O   1 
ATOM   5636 C CB  . LEU   B 1 281 ? 14.06669  24.36493  -35.12036 1.000 12.58863 ? 263  LEU   B CB  1 
ATOM   5637 C CG  . LEU   B 1 281 ? 13.36217  25.35482  -36.05381 1.000 13.77542 ? 263  LEU   B CG  1 
ATOM   5638 C CD1 . LEU   B 1 281 ? 12.11469  25.98193  -35.41821 1.000 10.45199 ? 263  LEU   B CD1 1 
ATOM   5639 C CD2 . LEU   B 1 281 ? 14.34076  26.45386  -36.48540 1.000 12.39152 ? 263  LEU   B CD2 1 
ATOM   5640 N N   . LEU   B 1 282 ? 15.84180  21.82610  -34.21159 1.000 12.43134 ? 264  LEU   B N   1 
ATOM   5641 C CA  . LEU   B 1 282 ? 16.65564  21.15327  -33.19982 1.000 13.02056 ? 264  LEU   B CA  1 
ATOM   5642 C C   . LEU   B 1 282 ? 18.05700  20.83279  -33.72320 1.000 14.40624 ? 264  LEU   B C   1 
ATOM   5643 O O   . LEU   B 1 282 ? 19.04358  20.96225  -32.98379 1.000 14.71261 ? 264  LEU   B O   1 
ATOM   5644 C CB  . LEU   B 1 282 ? 15.95352  19.87896  -32.71941 1.000 11.23990 ? 264  LEU   B CB  1 
ATOM   5645 C CG  . LEU   B 1 282 ? 14.78636  20.12082  -31.76342 1.000 10.00868 ? 264  LEU   B CG  1 
ATOM   5646 C CD1 . LEU   B 1 282 ? 14.12405  18.79088  -31.38855 1.000 14.77813 ? 264  LEU   B CD1 1 
ATOM   5647 C CD2 . LEU   B 1 282 ? 15.25343  20.92183  -30.52872 1.000 9.90575  ? 264  LEU   B CD2 1 
ATOM   5648 N N   . TRP   B 1 283 ? 18.17421  20.40586  -34.98853 1.000 15.40964 ? 265  TRP   B N   1 
ATOM   5649 C CA  . TRP   B 1 283 ? 19.50813  20.18122  -35.55037 1.000 15.54494 ? 265  TRP   B CA  1 
ATOM   5650 C C   . TRP   B 1 283 ? 20.29718  21.48251  -35.63311 1.000 17.87852 ? 265  TRP   B C   1 
ATOM   5651 O O   . TRP   B 1 283 ? 21.49923  21.50878  -35.33599 1.000 16.58493 ? 265  TRP   B O   1 
ATOM   5652 C CB  . TRP   B 1 283 ? 19.41426  19.51708  -36.93057 1.000 15.98170 ? 265  TRP   B CB  1 
ATOM   5653 C CG  . TRP   B 1 283 ? 19.23689  18.03602  -36.83341 1.000 16.00848 ? 265  TRP   B CG  1 
ATOM   5654 C CD1 . TRP   B 1 283 ? 18.23028  17.29154  -37.37716 1.000 15.99863 ? 265  TRP   B CD1 1 
ATOM   5655 C CD2 . TRP   B 1 283 ? 20.07200  17.11700  -36.11922 1.000 16.91940 ? 265  TRP   B CD2 1 
ATOM   5656 N NE1 . TRP   B 1 283 ? 18.39462  15.96684  -37.06035 1.000 17.07157 ? 265  TRP   B NE1 1 
ATOM   5657 C CE2 . TRP   B 1 283 ? 19.51715  15.83246  -36.28847 1.000 19.52936 ? 265  TRP   B CE2 1 
ATOM   5658 C CE3 . TRP   B 1 283 ? 21.24082  17.25259  -35.36360 1.000 15.71469 ? 265  TRP   B CE3 1 
ATOM   5659 C CZ2 . TRP   B 1 283 ? 20.08514  14.69147  -35.72050 1.000 18.57050 ? 265  TRP   B CZ2 1 
ATOM   5660 C CZ3 . TRP   B 1 283 ? 21.80593  16.11079  -34.80087 1.000 17.47668 ? 265  TRP   B CZ3 1 
ATOM   5661 C CH2 . TRP   B 1 283 ? 21.22276  14.85215  -34.98434 1.000 13.50907 ? 265  TRP   B CH2 1 
ATOM   5662 N N   . LEU   B 1 284 ? 19.63893  22.57256  -36.04302 1.000 15.52877 ? 266  LEU   B N   1 
ATOM   5663 C CA  . LEU   B 1 284 ? 20.27375  23.88574  -36.01820 1.000 12.98072 ? 266  LEU   B CA  1 
ATOM   5664 C C   . LEU   B 1 284 ? 20.83561  24.19429  -34.63545 1.000 17.64800 ? 266  LEU   B C   1 
ATOM   5665 O O   . LEU   B 1 284 ? 22.00022  24.59269  -34.49341 1.000 14.93020 ? 266  LEU   B O   1 
ATOM   5666 C CB  . LEU   B 1 284 ? 19.26009  24.95606  -36.44163 1.000 10.26680 ? 266  LEU   B CB  1 
ATOM   5667 C CG  . LEU   B 1 284 ? 19.78360  26.39531  -36.39885 1.000 15.97910 ? 266  LEU   B CG  1 
ATOM   5668 C CD1 . LEU   B 1 284 ? 20.89244  26.58425  -37.41409 1.000 20.60679 ? 266  LEU   B CD1 1 
ATOM   5669 C CD2 . LEU   B 1 284 ? 18.65732  27.40242  -36.64429 1.000 10.73242 ? 266  LEU   B CD2 1 
ATOM   5670 N N   . LEU   B 1 285 ? 20.01285  24.00962  -33.59643 1.000 14.20614 ? 267  LEU   B N   1 
ATOM   5671 C CA  . LEU   B 1 285 ? 20.46626  24.26353  -32.23235 1.000 10.87596 ? 267  LEU   B CA  1 
ATOM   5672 C C   . LEU   B 1 285 ? 21.56584  23.28813  -31.82481 1.000 9.51448  ? 267  LEU   B C   1 
ATOM   5673 O O   . LEU   B 1 285 ? 22.53372  23.67071  -31.15508 1.000 13.29212 ? 267  LEU   B O   1 
ATOM   5674 C CB  . LEU   B 1 285 ? 19.28233  24.15019  -31.26752 1.000 14.88175 ? 267  LEU   B CB  1 
ATOM   5675 C CG  . LEU   B 1 285 ? 18.21049  25.23443  -31.35076 1.000 11.95707 ? 267  LEU   B CG  1 
ATOM   5676 C CD1 . LEU   B 1 285 ? 16.85973  24.66102  -30.92960 1.000 11.84070 ? 267  LEU   B CD1 1 
ATOM   5677 C CD2 . LEU   B 1 285 ? 18.58896  26.44195  -30.48551 1.000 14.31972 ? 267  LEU   B CD2 1 
ATOM   5678 N N   . TYR   B 1 286 ? 21.40551  22.01921  -32.19576 1.000 17.12691 ? 268  TYR   B N   1 
ATOM   5679 C CA  . TYR   B 1 286 ? 22.41463  21.00819  -31.91017 1.000 11.10006 ? 268  TYR   B CA  1 
ATOM   5680 C C   . TYR   B 1 286 ? 23.77574  21.42761  -32.44835 1.000 15.53781 ? 268  TYR   B C   1 
ATOM   5681 O O   . TYR   B 1 286 ? 24.76959  21.43402  -31.71686 1.000 12.46411 ? 268  TYR   B O   1 
ATOM   5682 C CB  . TYR   B 1 286 ? 21.97954  19.68283  -32.52013 1.000 12.07859 ? 268  TYR   B CB  1 
ATOM   5683 C CG  . TYR   B 1 286 ? 22.92522  18.54112  -32.26383 1.000 20.27620 ? 268  TYR   B CG  1 
ATOM   5684 C CD1 . TYR   B 1 286 ? 23.98590  18.28584  -33.12299 1.000 18.75811 ? 268  TYR   B CD1 1 
ATOM   5685 C CD2 . TYR   B 1 286 ? 22.73958  17.69890  -31.17882 1.000 21.01439 ? 268  TYR   B CD2 1 
ATOM   5686 C CE1 . TYR   B 1 286 ? 24.84595  17.23376  -32.89906 1.000 19.71849 ? 268  TYR   B CE1 1 
ATOM   5687 C CE2 . TYR   B 1 286 ? 23.59500  16.63663  -30.94789 1.000 25.87002 ? 268  TYR   B CE2 1 
ATOM   5688 C CZ  . TYR   B 1 286 ? 24.64550  16.40893  -31.81248 1.000 29.80231 ? 268  TYR   B CZ  1 
ATOM   5689 O OH  . TYR   B 1 286 ? 25.50186  15.35336  -31.58071 1.000 27.64883 ? 268  TYR   B OH  1 
ATOM   5690 N N   . ASP   B 1 287 ? 23.82692  21.79851  -33.73012 1.000 14.92225 ? 269  ASP   B N   1 
ATOM   5691 C CA  . ASP   B 1 287 ? 25.09301  22.16155  -34.36097 1.000 22.80724 ? 269  ASP   B CA  1 
ATOM   5692 C C   . ASP   B 1 287 ? 25.72929  23.38366  -33.70745 1.000 23.00271 ? 269  ASP   B C   1 
ATOM   5693 O O   . ASP   B 1 287 ? 26.96135  23.50827  -33.68960 1.000 23.23605 ? 269  ASP   B O   1 
ATOM   5694 C CB  . ASP   B 1 287 ? 24.87749  22.40502  -35.85878 1.000 18.21043 ? 269  ASP   B CB  1 
ATOM   5695 C CG  . ASP   B 1 287 ? 24.64042  21.12107  -36.63368 1.000 21.36347 ? 269  ASP   B CG  1 
ATOM   5696 O OD1 . ASP   B 1 287 ? 24.95352  20.03184  -36.10566 1.000 20.35349 ? 269  ASP   B OD1 1 
ATOM   5697 O OD2 . ASP   B 1 287 ? 24.14700  21.19377  -37.78040 1.000 23.53560 ? 269  ASP   B OD2 1 
ATOM   5698 N N   . LEU   B 1 288 ? 24.92206  24.28606  -33.15276 1.000 18.04334 ? 270  LEU   B N   1 
ATOM   5699 C CA  . LEU   B 1 288 ? 25.46300  25.45627  -32.47473 1.000 14.63606 ? 270  LEU   B CA  1 
ATOM   5700 C C   . LEU   B 1 288 ? 25.85076  25.17775  -31.02705 1.000 17.41509 ? 270  LEU   B C   1 
ATOM   5701 O O   . LEU   B 1 288 ? 26.32436  26.09333  -30.34499 1.000 19.68971 ? 270  LEU   B O   1 
ATOM   5702 C CB  . LEU   B 1 288 ? 24.45473  26.60899  -32.52867 1.000 15.87085 ? 270  LEU   B CB  1 
ATOM   5703 C CG  . LEU   B 1 288 ? 24.06889  27.10083  -33.92313 1.000 22.82902 ? 270  LEU   B CG  1 
ATOM   5704 C CD1 . LEU   B 1 288 ? 22.89102  28.07975  -33.88038 1.000 17.15905 ? 270  LEU   B CD1 1 
ATOM   5705 C CD2 . LEU   B 1 288 ? 25.26822  27.72964  -34.61048 1.000 21.87847 ? 270  LEU   B CD2 1 
ATOM   5706 N N   . GLY   B 1 289 ? 25.63355  23.95808  -30.53464 1.000 16.45934 ? 271  GLY   B N   1 
ATOM   5707 C CA  . GLY   B 1 289 ? 25.97766  23.60172  -29.17206 1.000 16.53906 ? 271  GLY   B CA  1 
ATOM   5708 C C   . GLY   B 1 289 ? 24.91359  23.86315  -28.12539 1.000 14.71481 ? 271  GLY   B C   1 
ATOM   5709 O O   . GLY   B 1 289 ? 25.20286  23.74344  -26.92951 1.000 14.85282 ? 271  GLY   B O   1 
ATOM   5710 N N   . HIS   B 1 290 ? 23.68809  24.18943  -28.52251 1.000 18.46869 ? 272  HIS   B N   1 
ATOM   5711 C CA  . HIS   B 1 290 ? 22.70132  24.66823  -27.56429 1.000 14.63720 ? 272  HIS   B CA  1 
ATOM   5712 C C   . HIS   B 1 290 ? 21.82253  23.56830  -27.00086 1.000 13.55438 ? 272  HIS   B C   1 
ATOM   5713 O O   . HIS   B 1 290 ? 20.94552  23.86250  -26.18217 1.000 13.57875 ? 272  HIS   B O   1 
ATOM   5714 C CB  . HIS   B 1 290 ? 21.84148  25.75542  -28.20832 1.000 15.84996 ? 272  HIS   B CB  1 
ATOM   5715 C CG  . HIS   B 1 290 ? 22.64347  26.91526  -28.69524 1.000 16.23895 ? 272  HIS   B CG  1 
ATOM   5716 N ND1 . HIS   B 1 290 ? 23.53864  27.58518  -27.88893 1.000 19.75072 ? 272  HIS   B ND1 1 
ATOM   5717 C CD2 . HIS   B 1 290 ? 22.72104  27.49989  -29.91284 1.000 17.65558 ? 272  HIS   B CD2 1 
ATOM   5718 C CE1 . HIS   B 1 290 ? 24.11934  28.54618  -28.58377 1.000 19.59258 ? 272  HIS   B CE1 1 
ATOM   5719 N NE2 . HIS   B 1 290 ? 23.64506  28.51388  -29.81578 1.000 16.82089 ? 272  HIS   B NE2 1 
ATOM   5720 N N   . LEU   B 1 291 ? 22.03855  22.31736  -27.39984 1.000 12.29338 ? 273  LEU   B N   1 
ATOM   5721 C CA  . LEU   B 1 291 ? 21.38391  21.18916  -26.75576 1.000 14.02842 ? 273  LEU   B CA  1 
ATOM   5722 C C   . LEU   B 1 291 ? 22.31727  20.41881  -25.82619 1.000 13.56029 ? 273  LEU   B C   1 
ATOM   5723 O O   . LEU   B 1 291 ? 21.87712  19.44090  -25.21753 1.000 11.69639 ? 273  LEU   B O   1 
ATOM   5724 C CB  . LEU   B 1 291 ? 20.80778  20.23152  -27.80608 1.000 11.94739 ? 273  LEU   B CB  1 
ATOM   5725 C CG  . LEU   B 1 291 ? 19.83526  20.81997  -28.83717 1.000 13.59581 ? 273  LEU   B CG  1 
ATOM   5726 C CD1 . LEU   B 1 291 ? 19.10275  19.71842  -29.59549 1.000 11.63436 ? 273  LEU   B CD1 1 
ATOM   5727 C CD2 . LEU   B 1 291 ? 18.83615  21.79118  -28.17841 1.000 15.24033 ? 273  LEU   B CD2 1 
ATOM   5728 N N   . GLU   B 1 292 ? 23.58738  20.83322  -25.70427 1.000 12.28298 ? 274  GLU   B N   1 
ATOM   5729 C CA  . GLU   B 1 292 ? 24.55748  20.07023  -24.90868 1.000 17.00288 ? 274  GLU   B CA  1 
ATOM   5730 C C   . GLU   B 1 292 ? 24.09373  19.88833  -23.47072 1.000 11.07813 ? 274  GLU   B C   1 
ATOM   5731 O O   . GLU   B 1 292 ? 24.33659  18.84366  -22.85783 1.000 12.03139 ? 274  GLU   B O   1 
ATOM   5732 C CB  . GLU   B 1 292 ? 25.92395  20.75760  -24.91558 1.000 13.67257 ? 274  GLU   B CB  1 
ATOM   5733 C CG  . GLU   B 1 292 ? 26.56813  20.88376  -26.27886 1.000 19.10359 ? 274  GLU   B CG  1 
ATOM   5734 C CD  . GLU   B 1 292 ? 27.98856  21.40375  -26.18052 1.000 33.03480 ? 274  GLU   B CD  1 
ATOM   5735 O OE1 . GLU   B 1 292 ? 28.84826  20.94148  -26.96439 1.000 57.38585 ? 274  GLU   B OE1 1 
ATOM   5736 O OE2 . GLU   B 1 292 ? 28.24102  22.27519  -25.31762 1.000 50.38758 ? 274  GLU   B OE2 1 
ATOM   5737 N N   . ARG   B 1 293 ? 23.42523  20.89140  -22.91332 1.000 12.54324 ? 275  ARG   B N   1 
ATOM   5738 C CA  . ARG   B 1 293 ? 22.94329  20.83249  -21.54030 1.000 14.64244 ? 275  ARG   B CA  1 
ATOM   5739 C C   . ARG   B 1 293 ? 21.42615  20.66511  -21.46056 1.000 13.30374 ? 275  ARG   B C   1 
ATOM   5740 O O   . ARG   B 1 293 ? 20.80580  21.09196  -20.48308 1.000 10.51141 ? 275  ARG   B O   1 
ATOM   5741 C CB  . ARG   B 1 293 ? 23.37091  22.09065  -20.78175 1.000 14.00395 ? 275  ARG   B CB  1 
ATOM   5742 C CG  . ARG   B 1 293 ? 24.83319  22.46584  -20.93996 1.000 20.56452 ? 275  ARG   B CG  1 
ATOM   5743 C CD  . ARG   B 1 293 ? 25.18590  23.51314  -19.90183 1.000 32.79373 ? 275  ARG   B CD  1 
ATOM   5744 N NE  . ARG   B 1 293 ? 25.33569  24.84094  -20.48685 1.000 30.27996 ? 275  ARG   B NE  1 
ATOM   5745 C CZ  . ARG   B 1 293 ? 24.89582  25.95594  -19.91816 1.000 44.41962 ? 275  ARG   B CZ  1 
ATOM   5746 N NH1 . ARG   B 1 293 ? 24.24467  25.93346  -18.76587 1.000 53.72337 ? 275  ARG   B NH1 1 
ATOM   5747 N NH2 . ARG   B 1 293 ? 25.09255  27.12113  -20.53068 1.000 48.85702 ? 275  ARG   B NH2 1 
ATOM   5748 N N   . TYR   B 1 294 ? 20.81834  20.04604  -22.47141 1.000 12.89372 ? 276  TYR   B N   1 
ATOM   5749 C CA  . TYR   B 1 294 ? 19.36132  19.91492  -22.56722 1.000 13.14242 ? 276  TYR   B CA  1 
ATOM   5750 C C   . TYR   B 1 294 ? 19.01381  18.46791  -22.90010 1.000 8.43608  ? 276  TYR   B C   1 
ATOM   5751 O O   . TYR   B 1 294 ? 18.64435  18.15768  -24.04253 1.000 9.99493  ? 276  TYR   B O   1 
ATOM   5752 C CB  . TYR   B 1 294 ? 18.81094  20.88033  -23.61958 1.000 10.13153 ? 276  TYR   B CB  1 
ATOM   5753 C CG  . TYR   B 1 294 ? 17.34417  21.28556  -23.48713 1.000 8.91244  ? 276  TYR   B CG  1 
ATOM   5754 C CD1 . TYR   B 1 294 ? 16.41911  20.49331  -22.80946 1.000 9.05158  ? 276  TYR   B CD1 1 
ATOM   5755 C CD2 . TYR   B 1 294 ? 16.88834  22.46773  -24.07688 1.000 10.00718 ? 276  TYR   B CD2 1 
ATOM   5756 C CE1 . TYR   B 1 294 ? 15.06083  20.89089  -22.70705 1.000 10.00862 ? 276  TYR   B CE1 1 
ATOM   5757 C CE2 . TYR   B 1 294 ? 15.55393  22.86488  -23.98531 1.000 12.29925 ? 276  TYR   B CE2 1 
ATOM   5758 C CZ  . TYR   B 1 294 ? 14.64485  22.07547  -23.30999 1.000 13.02473 ? 276  TYR   B CZ  1 
ATOM   5759 O OH  . TYR   B 1 294 ? 13.32015  22.48986  -23.23696 1.000 11.45676 ? 276  TYR   B OH  1 
ATOM   5760 N N   . PRO   B 1 295 ? 19.11913  17.55310  -21.91975 1.000 9.78053  ? 277  PRO   B N   1 
ATOM   5761 C CA  . PRO   B 1 295 ? 18.81428  16.13546  -22.19037 1.000 7.37606  ? 277  PRO   B CA  1 
ATOM   5762 C C   . PRO   B 1 295 ? 17.45293  15.87344  -22.82295 1.000 10.40584 ? 277  PRO   B C   1 
ATOM   5763 O O   . PRO   B 1 295 ? 17.35322  15.02408  -23.71424 1.000 9.78783  ? 277  PRO   B O   1 
ATOM   5764 C CB  . PRO   B 1 295 ? 18.89227  15.50445  -20.79349 1.000 10.78755 ? 277  PRO   B CB  1 
ATOM   5765 C CG  . PRO   B 1 295 ? 19.95742  16.31705  -20.10758 1.000 12.77427 ? 277  PRO   B CG  1 
ATOM   5766 C CD  . PRO   B 1 295 ? 19.69675  17.73911  -20.57123 1.000 10.51523 ? 277  PRO   B CD  1 
ATOM   5767 N N   . MET   B 1 296 ? 16.38933  16.54581  -22.37202 1.000 9.57442  ? 278  MET   B N   1 
ATOM   5768 C CA  . MET   B 1 296 ? 15.08211  16.26141  -22.95596 1.000 9.27188  ? 278  MET   B CA  1 
ATOM   5769 C C   . MET   B 1 296 ? 15.01623  16.68563  -24.41738 1.000 8.78839  ? 278  MET   B C   1 
ATOM   5770 O O   . MET   B 1 296 ? 14.36796  16.01314  -25.22577 1.000 10.24238 ? 278  MET   B O   1 
ATOM   5771 C CB  . MET   B 1 296 ? 13.96463  16.93711  -22.15469 1.000 9.17029  ? 278  MET   B CB  1 
ATOM   5772 C CG  . MET   B 1 296 ? 13.68999  16.31503  -20.79730 1.000 14.28222 ? 278  MET   B CG  1 
ATOM   5773 S SD  . MET   B 1 296 ? 12.32933  17.17100  -19.95045 1.000 11.57774 ? 278  MET   B SD  1 
ATOM   5774 C CE  . MET   B 1 296 ? 13.12962  18.68782  -19.46655 1.000 8.37747  ? 278  MET   B CE  1 
ATOM   5775 N N   . ALA   B 1 297 ? 15.68348  17.78034  -24.77998 1.000 10.57661 ? 279  ALA   B N   1 
ATOM   5776 C CA  . ALA   B 1 297 ? 15.71970  18.17600  -26.18807 1.000 9.65519  ? 279  ALA   B CA  1 
ATOM   5777 C C   . ALA   B 1 297 ? 16.45729  17.14077  -27.03638 1.000 12.60820 ? 279  ALA   B C   1 
ATOM   5778 O O   . ALA   B 1 297 ? 16.08119  16.88600  -28.19148 1.000 10.51506 ? 279  ALA   B O   1 
ATOM   5779 C CB  . ALA   B 1 297 ? 16.37209  19.54942  -26.32484 1.000 10.38644 ? 279  ALA   B CB  1 
ATOM   5780 N N   . LEU   B 1 298 ? 17.51008  16.53562  -26.47910 1.000 11.62982 ? 280  LEU   B N   1 
ATOM   5781 C CA  . LEU   B 1 298 ? 18.22011  15.47146  -27.18414 1.000 10.02160 ? 280  LEU   B CA  1 
ATOM   5782 C C   . LEU   B 1 298 ? 17.34798  14.23557  -27.35372 1.000 14.32907 ? 280  LEU   B C   1 
ATOM   5783 O O   . LEU   B 1 298 ? 17.43423  13.54375  -28.37621 1.000 13.02534 ? 280  LEU   B O   1 
ATOM   5784 C CB  . LEU   B 1 298 ? 19.51166  15.12309  -26.43475 1.000 10.94687 ? 280  LEU   B CB  1 
ATOM   5785 C CG  . LEU   B 1 298 ? 20.57414  16.22734  -26.41421 1.000 10.83033 ? 280  LEU   B CG  1 
ATOM   5786 C CD1 . LEU   B 1 298 ? 21.65945  15.93950  -25.37791 1.000 10.68142 ? 280  LEU   B CD1 1 
ATOM   5787 C CD2 . LEU   B 1 298 ? 21.18523  16.44258  -27.79741 1.000 15.21753 ? 280  LEU   B CD2 1 
ATOM   5788 N N   . GLY   B 1 299 ? 16.52523  13.91726  -26.35152 1.000 12.53535 ? 281  GLY   B N   1 
ATOM   5789 C CA  . GLY   B 1 299 ? 15.60224  12.80020  -26.49929 1.000 12.35805 ? 281  GLY   B CA  1 
ATOM   5790 C C   . GLY   B 1 299 ? 14.49624  13.08900  -27.49570 1.000 14.57788 ? 281  GLY   B C   1 
ATOM   5791 O O   . GLY   B 1 299 ? 14.08541  12.20474  -28.25351 1.000 14.68582 ? 281  GLY   B O   1 
ATOM   5792 N N   . ASN   B 1 300 ? 13.97966  14.32257  -27.48309 1.000 14.78494 ? 282  ASN   B N   1 
ATOM   5793 C CA  . ASN   B 1 300 ? 13.02933  14.78215  -28.49763 1.000 13.13257 ? 282  ASN   B CA  1 
ATOM   5794 C C   . ASN   B 1 300 ? 13.59190  14.58774  -29.90067 1.000 15.03595 ? 282  ASN   B C   1 
ATOM   5795 O O   . ASN   B 1 300 ? 12.91815  14.05805  -30.79415 1.000 18.42306 ? 282  ASN   B O   1 
ATOM   5796 C CB  . ASN   B 1 300 ? 12.72649  16.26422  -28.24487 1.000 13.03029 ? 282  ASN   B CB  1 
ATOM   5797 C CG  . ASN   B 1 300 ? 11.44364  16.74670  -28.89292 1.000 32.97330 ? 282  ASN   B CG  1 
ATOM   5798 O OD1 . ASN   B 1 300 ? 10.85878  17.74157  -28.44650 1.000 25.13627 ? 282  ASN   B OD1 1 
ATOM   5799 N ND2 . ASN   B 1 300 ? 11.00725  16.07336  -29.96003 1.000 29.00996 ? 282  ASN   B ND2 1 
ATOM   5800 N N   . LEU   B 1 301 ? 14.82896  15.03768  -30.11031 1.000 9.54026  ? 283  LEU   B N   1 
ATOM   5801 C CA  . LEU   B 1 301 ? 15.46039  14.92079  -31.42188 1.000 15.47025 ? 283  LEU   B CA  1 
ATOM   5802 C C   . LEU   B 1 301 ? 15.63208  13.45597  -31.81634 1.000 13.68694 ? 283  LEU   B C   1 
ATOM   5803 O O   . LEU   B 1 301 ? 15.32478  13.07374  -32.95084 1.000 19.22683 ? 283  LEU   B O   1 
ATOM   5804 C CB  . LEU   B 1 301 ? 16.79867  15.66102  -31.41750 1.000 10.87004 ? 283  LEU   B CB  1 
ATOM   5805 C CG  . LEU   B 1 301 ? 17.66042  15.72481  -32.68816 1.000 12.59860 ? 283  LEU   B CG  1 
ATOM   5806 C CD1 . LEU   B 1 301 ? 16.83844  16.22081  -33.86220 1.000 16.05581 ? 283  LEU   B CD1 1 
ATOM   5807 C CD2 . LEU   B 1 301 ? 18.88418  16.61238  -32.45103 1.000 16.20801 ? 283  LEU   B CD2 1 
ATOM   5808 N N   . ALA   B 1 302 ? 16.04687  12.60661  -30.87227 1.000 16.04887 ? 284  ALA   B N   1 
ATOM   5809 C CA  . ALA   B 1 302 ? 16.16549  11.18084  -31.17629 1.000 13.47331 ? 284  ALA   B CA  1 
ATOM   5810 C C   . ALA   B 1 302 ? 14.81426  10.58064  -31.55466 1.000 17.50750 ? 284  ALA   B C   1 
ATOM   5811 O O   . ALA   B 1 302 ? 14.72446  9.78061   -32.49589 1.000 23.15258 ? 284  ALA   B O   1 
ATOM   5812 C CB  . ALA   B 1 302 ? 16.77741  10.43817  -29.98876 1.000 17.42501 ? 284  ALA   B CB  1 
ATOM   5813 N N   . ASP   B 1 303 ? 13.75186  10.95335  -30.83371 1.000 18.08216 ? 285  ASP   B N   1 
ATOM   5814 C CA  . ASP   B 1 303 ? 12.40942  10.48786  -31.17878 1.000 20.85484 ? 285  ASP   B CA  1 
ATOM   5815 C C   . ASP   B 1 303 ? 12.04159  10.87577  -32.60578 1.000 24.79288 ? 285  ASP   B C   1 
ATOM   5816 O O   . ASP   B 1 303 ? 11.41618  10.09057  -33.32939 1.000 23.40428 ? 285  ASP   B O   1 
ATOM   5817 C CB  . ASP   B 1 303 ? 11.38027  11.06783  -30.20415 1.000 23.21856 ? 285  ASP   B CB  1 
ATOM   5818 C CG  . ASP   B 1 303 ? 11.38292  10.36919  -28.85003 1.000 18.80320 ? 285  ASP   B CG  1 
ATOM   5819 O OD1 . ASP   B 1 303 ? 12.15332  9.40685   -28.65250 1.000 22.80601 ? 285  ASP   B OD1 1 
ATOM   5820 O OD2 . ASP   B 1 303 ? 10.61764  10.80934  -27.97382 1.000 26.38765 ? 285  ASP   B OD2 1 
ATOM   5821 N N   . LEU   B 1 304 ? 12.40061  12.09582  -33.01664 1.000 17.40189 ? 286  LEU   B N   1 
ATOM   5822 C CA  . LEU   B 1 304 ? 12.12543  12.54306  -34.37850 1.000 20.76684 ? 286  LEU   B CA  1 
ATOM   5823 C C   . LEU   B 1 304 ? 12.93146  11.73853  -35.39464 1.000 23.81430 ? 286  LEU   B C   1 
ATOM   5824 O O   . LEU   B 1 304 ? 12.39253  11.29692  -36.41449 1.000 24.83098 ? 286  LEU   B O   1 
ATOM   5825 C CB  . LEU   B 1 304 ? 12.42823  14.03855  -34.51300 1.000 15.95960 ? 286  LEU   B CB  1 
ATOM   5826 C CG  . LEU   B 1 304 ? 11.47872  14.99163  -33.76414 1.000 19.50489 ? 286  LEU   B CG  1 
ATOM   5827 C CD1 . LEU   B 1 304 ? 12.05420  16.39371  -33.60254 1.000 15.21471 ? 286  LEU   B CD1 1 
ATOM   5828 C CD2 . LEU   B 1 304 ? 10.13436  15.05259  -34.46151 1.000 20.11519 ? 286  LEU   B CD2 1 
ATOM   5829 N N   . GLU   B 1 305 ? 14.22849  11.54596  -35.13162 1.000 19.61375 ? 287  GLU   B N   1 
ATOM   5830 C CA  . GLU   B 1 305 ? 15.08348  10.78810  -36.04423 1.000 19.38561 ? 287  GLU   B CA  1 
ATOM   5831 C C   . GLU   B 1 305 ? 14.61339  9.34895   -36.18436 1.000 23.98268 ? 287  GLU   B C   1 
ATOM   5832 O O   . GLU   B 1 305 ? 14.81796  8.72179   -37.23153 1.000 23.47316 ? 287  GLU   B O   1 
ATOM   5833 C CB  . GLU   B 1 305 ? 16.53368  10.82057  -35.55319 1.000 22.21865 ? 287  GLU   B CB  1 
ATOM   5834 C CG  . GLU   B 1 305 ? 17.23599  12.15234  -35.77168 1.000 23.07875 ? 287  GLU   B CG  1 
ATOM   5835 C CD  . GLU   B 1 305 ? 17.39083  12.47442  -37.24492 1.000 23.76318 ? 287  GLU   B CD  1 
ATOM   5836 O OE1 . GLU   B 1 305 ? 17.92515  11.61706  -37.97457 1.000 23.49665 ? 287  GLU   B OE1 1 
ATOM   5837 O OE2 . GLU   B 1 305 ? 16.96583  13.57088  -37.66987 1.000 23.09900 ? 287  GLU   B OE2 1 
ATOM   5838 N N   . GLU   B 1 306 ? 13.99243  8.80616   -35.14046 1.000 22.02673 ? 288  GLU   B N   1 
ATOM   5839 C CA  . GLU   B 1 306 ? 13.44875  7.45777   -35.22972 1.000 26.64751 ? 288  GLU   B CA  1 
ATOM   5840 C C   . GLU   B 1 306 ? 12.29590  7.40240   -36.22611 1.000 27.24651 ? 288  GLU   B C   1 
ATOM   5841 O O   . GLU   B 1 306 ? 12.16256  6.42085   -36.96730 1.000 28.59134 ? 288  GLU   B O   1 
ATOM   5842 C CB  . GLU   B 1 306 ? 13.02311  6.98147   -33.83538 1.000 22.51046 ? 288  GLU   B CB  1 
ATOM   5843 C CG  . GLU   B 1 306 ? 12.68853  5.48982   -33.73666 1.000 38.20881 ? 288  GLU   B CG  1 
ATOM   5844 C CD  . GLU   B 1 306 ? 12.22109  5.07522   -32.34111 1.000 37.90360 ? 288  GLU   B CD  1 
ATOM   5845 O OE1 . GLU   B 1 306 ? 12.27189  5.91056   -31.40912 1.000 32.13095 ? 288  GLU   B OE1 1 
ATOM   5846 O OE2 . GLU   B 1 306 ? 11.79862  3.90989   -32.17322 1.000 49.99069 ? 288  GLU   B OE2 1 
ATOM   5847 N N   . LEU   B 1 307 ? 11.47071  8.45937   -36.28350 1.000 30.55963 ? 289  LEU   B N   1 
ATOM   5848 C CA  . LEU   B 1 307 ? 10.37381  8.49899   -37.25347 1.000 29.98753 ? 289  LEU   B CA  1 
ATOM   5849 C C   . LEU   B 1 307 ? 10.88022  8.78255   -38.65947 1.000 29.38029 ? 289  LEU   B C   1 
ATOM   5850 O O   . LEU   B 1 307 ? 10.42805  8.15856   -39.62556 1.000 35.15512 ? 289  LEU   B O   1 
ATOM   5851 C CB  . LEU   B 1 307 ? 9.34311   9.57012   -36.88366 1.000 30.05300 ? 289  LEU   B CB  1 
ATOM   5852 C CG  . LEU   B 1 307 ? 9.05343   9.97950   -35.44531 1.000 40.88724 ? 289  LEU   B CG  1 
ATOM   5853 C CD1 . LEU   B 1 307 ? 8.21163   11.25794  -35.44987 1.000 32.68405 ? 289  LEU   B CD1 1 
ATOM   5854 C CD2 . LEU   B 1 307 ? 8.34061   8.85681   -34.70107 1.000 41.84414 ? 289  LEU   B CD2 1 
ATOM   5855 N N   . GLU   B 1 308 ? 11.78650  9.74855   -38.79684 1.000 19.19131 ? 290  GLU   B N   1 
ATOM   5856 C CA  . GLU   B 1 308 ? 12.29572  10.17040  -40.10032 1.000 25.63921 ? 290  GLU   B CA  1 
ATOM   5857 C C   . GLU   B 1 308 ? 13.77340  10.49329  -39.96337 1.000 30.73003 ? 290  GLU   B C   1 
ATOM   5858 O O   . GLU   B 1 308 ? 14.15331  11.61787  -39.60888 1.000 26.79634 ? 290  GLU   B O   1 
ATOM   5859 C CB  . GLU   B 1 308 ? 11.52020  11.36761  -40.64639 1.000 32.63311 ? 290  GLU   B CB  1 
ATOM   5860 C CG  . GLU   B 1 308 ? 11.95452  11.76679  -42.04276 1.000 46.12615 ? 290  GLU   B CG  1 
ATOM   5861 C CD  . GLU   B 1 308 ? 11.24266  10.97363  -43.12461 1.000 50.44489 ? 290  GLU   B CD  1 
ATOM   5862 O OE1 . GLU   B 1 308 ? 10.14147  10.44100  -42.86096 1.000 45.78339 ? 290  GLU   B OE1 1 
ATOM   5863 O OE2 . GLU   B 1 308 ? 11.79643  10.87106  -44.23917 1.000 64.43133 ? 290  GLU   B OE2 1 
ATOM   5864 N N   . PRO   B 1 309 ? 14.64068  9.51784   -40.21906 1.000 22.24115 ? 291  PRO   B N   1 
ATOM   5865 C CA  . PRO   B 1 309 ? 16.07905  9.75525   -40.06268 1.000 25.79192 ? 291  PRO   B CA  1 
ATOM   5866 C C   . PRO   B 1 309 ? 16.59290  10.76278  -41.07624 1.000 26.78284 ? 291  PRO   B C   1 
ATOM   5867 O O   . PRO   B 1 309 ? 16.13850  10.81525  -42.22174 1.000 30.99606 ? 291  PRO   B O   1 
ATOM   5868 C CB  . PRO   B 1 309 ? 16.70417  8.37006   -40.27999 1.000 25.07213 ? 291  PRO   B CB  1 
ATOM   5869 C CG  . PRO   B 1 309 ? 15.62290  7.52321   -40.88352 1.000 26.95999 ? 291  PRO   B CG  1 
ATOM   5870 C CD  . PRO   B 1 309 ? 14.31644  8.10434   -40.47366 1.000 25.38543 ? 291  PRO   B CD  1 
ATOM   5871 N N   . THR   B 1 310 ? 17.54265  11.57951  -40.63023 1.000 26.49793 ? 292  THR   B N   1 
ATOM   5872 C CA  . THR   B 1 310 ? 18.15648  12.58702  -41.47585 1.000 26.33680 ? 292  THR   B CA  1 
ATOM   5873 C C   . THR   B 1 310 ? 19.48161  12.05021  -41.97831 1.000 31.12660 ? 292  THR   B C   1 
ATOM   5874 O O   . THR   B 1 310 ? 20.32313  11.65102  -41.15506 1.000 25.18056 ? 292  THR   B O   1 
ATOM   5875 C CB  . THR   B 1 310 ? 18.37725  13.88218  -40.70230 1.000 24.49615 ? 292  THR   B CB  1 
ATOM   5876 O OG1 . THR   B 1 310 ? 17.12194  14.38450  -40.22311 1.000 25.45022 ? 292  THR   B OG1 1 
ATOM   5877 C CG2 . THR   B 1 310 ? 19.02872  14.92560  -41.59483 1.000 18.25568 ? 292  THR   B CG2 1 
ATOM   5878 N N   . PRO   B 1 311 ? 19.71628  12.00633  -43.28948 1.000 39.98591 ? 293  PRO   B N   1 
ATOM   5879 C CA  . PRO   B 1 311 ? 20.98673  11.46325  -43.78574 1.000 35.66005 ? 293  PRO   B CA  1 
ATOM   5880 C C   . PRO   B 1 311 ? 22.17527  12.20801  -43.19694 1.000 24.89006 ? 293  PRO   B C   1 
ATOM   5881 O O   . PRO   B 1 311 ? 22.16216  13.43292  -43.05760 1.000 29.90136 ? 293  PRO   B O   1 
ATOM   5882 C CB  . PRO   B 1 311 ? 20.88561  11.65455  -45.30402 1.000 38.99728 ? 293  PRO   B CB  1 
ATOM   5883 C CG  . PRO   B 1 311 ? 19.41509  11.70155  -45.57752 1.000 31.52644 ? 293  PRO   B CG  1 
ATOM   5884 C CD  . PRO   B 1 311 ? 18.81182  12.39102  -44.38655 1.000 35.06963 ? 293  PRO   B CD  1 
ATOM   5885 N N   . GLY   B 1 312 ? 23.19913  11.44575  -42.81790 1.000 23.22783 ? 294  GLY   B N   1 
ATOM   5886 C CA  . GLY   B 1 312 ? 24.40906  12.00328  -42.25265 1.000 27.57752 ? 294  GLY   B CA  1 
ATOM   5887 C C   . GLY   B 1 312 ? 24.37056  12.26120  -40.75958 1.000 29.79431 ? 294  GLY   B C   1 
ATOM   5888 O O   . GLY   B 1 312 ? 25.41757  12.56052  -40.17383 1.000 25.85891 ? 294  GLY   B O   1 
ATOM   5889 N N   . ARG   B 1 313 ? 23.21409  12.13468  -40.12053 1.000 25.17500 ? 295  ARG   B N   1 
ATOM   5890 C CA  . ARG   B 1 313 ? 23.07578  12.48834  -38.71323 1.000 22.88538 ? 295  ARG   B CA  1 
ATOM   5891 C C   . ARG   B 1 313 ? 23.21401  11.26131  -37.81864 1.000 26.82224 ? 295  ARG   B C   1 
ATOM   5892 O O   . ARG   B 1 313 ? 23.03116  10.12544  -38.26731 1.000 23.28233 ? 295  ARG   B O   1 
ATOM   5893 C CB  . ARG   B 1 313 ? 21.71661  13.15858  -38.47462 1.000 26.07567 ? 295  ARG   B CB  1 
ATOM   5894 C CG  . ARG   B 1 313 ? 21.59916  14.55330  -39.07870 1.000 25.96450 ? 295  ARG   B CG  1 
ATOM   5895 C CD  . ARG   B 1 313 ? 22.68066  15.48802  -38.55476 1.000 20.53342 ? 295  ARG   B CD  1 
ATOM   5896 N NE  . ARG   B 1 313 ? 22.44914  16.87938  -38.92352 1.000 21.91834 ? 295  ARG   B NE  1 
ATOM   5897 C CZ  . ARG   B 1 313 ? 23.10938  17.90810  -38.40691 1.000 17.14863 ? 295  ARG   B CZ  1 
ATOM   5898 N NH1 . ARG   B 1 313 ? 24.03472  17.74074  -37.47606 1.000 19.02451 ? 295  ARG   B NH1 1 
ATOM   5899 N NH2 . ARG   B 1 313 ? 22.84268  19.13618  -38.83988 1.000 18.04807 ? 295  ARG   B NH2 1 
ATOM   5900 N N   . PRO   B 1 314 ? 23.53281  11.46019  -36.53621 1.000 19.47414 ? 296  PRO   B N   1 
ATOM   5901 C CA  . PRO   B 1 314 ? 23.63594  10.32487  -35.60930 1.000 24.26836 ? 296  PRO   B CA  1 
ATOM   5902 C C   . PRO   B 1 314 ? 22.34103  9.53021   -35.51328 1.000 19.70597 ? 296  PRO   B C   1 
ATOM   5903 O O   . PRO   B 1 314 ? 21.24251  10.06055  -35.69878 1.000 23.86254 ? 296  PRO   B O   1 
ATOM   5904 C CB  . PRO   B 1 314 ? 23.96021  10.99734  -34.27255 1.000 26.72975 ? 296  PRO   B CB  1 
ATOM   5905 C CG  . PRO   B 1 314 ? 24.66685  12.25301  -34.66401 1.000 32.19043 ? 296  PRO   B CG  1 
ATOM   5906 C CD  . PRO   B 1 314 ? 23.98735  12.71790  -35.91526 1.000 23.98007 ? 296  PRO   B CD  1 
ATOM   5907 N N   . ASP   B 1 315 ? 22.48565  8.23808   -35.21554 1.000 21.80071 ? 297  ASP   B N   1 
ATOM   5908 C CA  . ASP   B 1 315 ? 21.33983  7.37745   -34.96712 1.000 24.77595 ? 297  ASP   B CA  1 
ATOM   5909 C C   . ASP   B 1 315 ? 20.61012  7.79172   -33.69241 1.000 21.24384 ? 297  ASP   B C   1 
ATOM   5910 O O   . ASP   B 1 315 ? 21.19864  8.41106   -32.80119 1.000 19.84379 ? 297  ASP   B O   1 
ATOM   5911 C CB  . ASP   B 1 315 ? 21.76941  5.91311   -34.84457 1.000 29.79032 ? 297  ASP   B CB  1 
ATOM   5912 C CG  . ASP   B 1 315 ? 22.39641  5.37676   -36.11097 1.000 49.62067 ? 297  ASP   B CG  1 
ATOM   5913 O OD1 . ASP   B 1 315 ? 22.18179  5.98470   -37.18300 1.000 43.19664 ? 297  ASP   B OD1 1 
ATOM   5914 O OD2 . ASP   B 1 315 ? 23.09052  4.33998   -36.03482 1.000 54.66946 ? 297  ASP   B OD2 1 
ATOM   5915 N N   . PRO   B 1 316 ? 19.32305  7.44064   -33.58487 1.000 18.40069 ? 298  PRO   B N   1 
ATOM   5916 C CA  . PRO   B 1 316 ? 18.57328  7.73758   -32.35088 1.000 21.74694 ? 298  PRO   B CA  1 
ATOM   5917 C C   . PRO   B 1 316 ? 19.24495  7.22223   -31.08806 1.000 17.40162 ? 298  PRO   B C   1 
ATOM   5918 O O   . PRO   B 1 316 ? 19.24796  7.91453   -30.06251 1.000 17.54556 ? 298  PRO   B O   1 
ATOM   5919 C CB  . PRO   B 1 316 ? 17.22334  7.04634   -32.60218 1.000 21.10709 ? 298  PRO   B CB  1 
ATOM   5920 C CG  . PRO   B 1 316 ? 17.07203  7.06427   -34.10303 1.000 17.22874 ? 298  PRO   B CG  1 
ATOM   5921 C CD  . PRO   B 1 316 ? 18.46641  6.83105   -34.62003 1.000 19.63786 ? 298  PRO   B CD  1 
ATOM   5922 N N   . LEU   B 1 317 ? 19.84016  6.02726   -31.13947 1.000 13.85231 ? 299  LEU   B N   1 
ATOM   5923 C CA  . LEU   B 1 317 ? 20.46748  5.47591   -29.94563 1.000 16.04219 ? 299  LEU   B CA  1 
ATOM   5924 C C   . LEU   B 1 317 ? 21.64142  6.32766   -29.48750 1.000 18.19754 ? 299  LEU   B C   1 
ATOM   5925 O O   . LEU   B 1 317 ? 21.83292  6.52908   -28.28154 1.000 13.98105 ? 299  LEU   B O   1 
ATOM   5926 C CB  . LEU   B 1 317 ? 20.89829  4.03362   -30.21101 1.000 27.26922 ? 299  LEU   B CB  1 
ATOM   5927 C CG  . LEU   B 1 317 ? 21.46764  3.19046   -29.07446 1.000 27.36610 ? 299  LEU   B CG  1 
ATOM   5928 C CD1 . LEU   B 1 317 ? 20.43093  2.97380   -27.98323 1.000 18.61745 ? 299  LEU   B CD1 1 
ATOM   5929 C CD2 . LEU   B 1 317 ? 21.89328  1.85328   -29.65529 1.000 31.06635 ? 299  LEU   B CD2 1 
ATOM   5930 N N   . THR   B 1 318 ? 22.44546  6.83037   -30.43200 1.000 13.34408 ? 300  THR   B N   1 
ATOM   5931 C CA  . THR   B 1 318 ? 23.53329  7.73551   -30.07071 1.000 16.49632 ? 300  THR   B CA  1 
ATOM   5932 C C   . THR   B 1 318 ? 22.99995  8.96931   -29.35541 1.000 18.29075 ? 300  THR   B C   1 
ATOM   5933 O O   . THR   B 1 318 ? 23.59701  9.44260   -28.38023 1.000 18.02432 ? 300  THR   B O   1 
ATOM   5934 C CB  . THR   B 1 318 ? 24.31902  8.13473   -31.32690 1.000 17.28740 ? 300  THR   B CB  1 
ATOM   5935 O OG1 . THR   B 1 318 ? 24.86059  6.95942   -31.94552 1.000 21.53996 ? 300  THR   B OG1 1 
ATOM   5936 C CG2 . THR   B 1 318 ? 25.44041  9.11098   -31.00734 1.000 16.24839 ? 300  THR   B CG2 1 
ATOM   5937 N N   . LEU   B 1 319 ? 21.86720  9.49644   -29.82399 1.000 16.21636 ? 301  LEU   B N   1 
ATOM   5938 C CA  . LEU   B 1 319 ? 21.30650  10.70352  -29.22872 1.000 13.80605 ? 301  LEU   B CA  1 
ATOM   5939 C C   . LEU   B 1 319 ? 20.73626  10.43146  -27.84284 1.000 15.24619 ? 301  LEU   B C   1 
ATOM   5940 O O   . LEU   B 1 319 ? 20.89209  11.25688  -26.93349 1.000 14.85850 ? 301  LEU   B O   1 
ATOM   5941 C CB  . LEU   B 1 319 ? 20.23377  11.27947  -30.14275 1.000 11.68884 ? 301  LEU   B CB  1 
ATOM   5942 C CG  . LEU   B 1 319 ? 20.79894  11.85262  -31.44943 1.000 19.74079 ? 301  LEU   B CG  1 
ATOM   5943 C CD1 . LEU   B 1 319 ? 19.71631  11.95619  -32.51453 1.000 25.27427 ? 301  LEU   B CD1 1 
ATOM   5944 C CD2 . LEU   B 1 319 ? 21.44668  13.20954  -31.20510 1.000 22.24949 ? 301  LEU   B CD2 1 
ATOM   5945 N N   . TYR   B 1 320 ? 20.04555  9.29826   -27.66972 1.000 12.23120 ? 302  TYR   B N   1 
ATOM   5946 C CA  . TYR   B 1 320 ? 19.56660  8.92746   -26.33937 1.000 12.44529 ? 302  TYR   B CA  1 
ATOM   5947 C C   . TYR   B 1 320 ? 20.71794  8.81695   -25.35714 1.000 16.29754 ? 302  TYR   B C   1 
ATOM   5948 O O   . TYR   B 1 320 ? 20.62239  9.28931   -24.21947 1.000 11.80271 ? 302  TYR   B O   1 
ATOM   5949 C CB  . TYR   B 1 320 ? 18.79692  7.60117   -26.37828 1.000 13.73523 ? 302  TYR   B CB  1 
ATOM   5950 C CG  . TYR   B 1 320 ? 17.49780  7.64516   -27.12639 1.000 18.28461 ? 302  TYR   B CG  1 
ATOM   5951 C CD1 . TYR   B 1 320 ? 16.52755  8.59496   -26.82161 1.000 16.56871 ? 302  TYR   B CD1 1 
ATOM   5952 C CD2 . TYR   B 1 320 ? 17.22394  6.71895   -28.12448 1.000 18.90753 ? 302  TYR   B CD2 1 
ATOM   5953 C CE1 . TYR   B 1 320 ? 15.31754  8.62349   -27.50797 1.000 17.04244 ? 302  TYR   B CE1 1 
ATOM   5954 C CE2 . TYR   B 1 320 ? 16.04039  6.74641   -28.81413 1.000 17.73947 ? 302  TYR   B CE2 1 
ATOM   5955 C CZ  . TYR   B 1 320 ? 15.08500  7.69974   -28.50426 1.000 15.79349 ? 302  TYR   B CZ  1 
ATOM   5956 O OH  . TYR   B 1 320 ? 13.89480  7.71283   -29.19359 1.000 20.35819 ? 302  TYR   B OH  1 
ATOM   5957 N N   . HIS   B 1 321 ? 21.81453  8.17689   -25.76808 1.000 16.68205 ? 303  HIS   B N   1 
ATOM   5958 C CA  . HIS   B 1 321 ? 22.95275  8.08068   -24.86497 1.000 15.81697 ? 303  HIS   B CA  1 
ATOM   5959 C C   . HIS   B 1 321 ? 23.60422  9.43584   -24.65245 1.000 13.84334 ? 303  HIS   B C   1 
ATOM   5960 O O   . HIS   B 1 321 ? 24.17369  9.68530   -23.58389 1.000 18.06551 ? 303  HIS   B O   1 
ATOM   5961 C CB  . HIS   B 1 321 ? 23.95819  7.05413   -25.38410 1.000 17.92151 ? 303  HIS   B CB  1 
ATOM   5962 C CG  . HIS   B 1 321 ? 23.56626  5.64090   -25.08310 1.000 18.64311 ? 303  HIS   B CG  1 
ATOM   5963 N ND1 . HIS   B 1 321 ? 23.59112  5.12275   -23.80584 1.000 27.32189 ? 303  HIS   B ND1 1 
ATOM   5964 C CD2 . HIS   B 1 321 ? 23.11410  4.64816   -25.88377 1.000 22.74521 ? 303  HIS   B CD2 1 
ATOM   5965 C CE1 . HIS   B 1 321 ? 23.18510  3.86618   -23.83562 1.000 31.78662 ? 303  HIS   B CE1 1 
ATOM   5966 N NE2 . HIS   B 1 321 ? 22.89196  3.55320   -25.08496 1.000 25.96737 ? 303  HIS   B NE2 1 
ATOM   5967 N N   . LYS   B 1 322 ? 23.51333  10.33681  -25.63039 1.000 11.17140 ? 304  LYS   B N   1 
ATOM   5968 C CA  . LYS   B 1 322 ? 24.08258  11.65625  -25.39569 1.000 14.41319 ? 304  LYS   B CA  1 
ATOM   5969 C C   . LYS   B 1 322 ? 23.23007  12.44730  -24.40721 1.000 11.92784 ? 304  LYS   B C   1 
ATOM   5970 O O   . LYS   B 1 322 ? 23.76668  13.23353  -23.61732 1.000 13.58790 ? 304  LYS   B O   1 
ATOM   5971 C CB  . LYS   B 1 322 ? 24.24637  12.39887  -26.72110 1.000 18.58480 ? 304  LYS   B CB  1 
ATOM   5972 C CG  . LYS   B 1 322 ? 25.06279  13.67095  -26.59784 1.000 29.63503 ? 304  LYS   B CG  1 
ATOM   5973 C CD  . LYS   B 1 322 ? 24.98494  14.49304  -27.87384 1.000 37.98293 ? 304  LYS   B CD  1 
ATOM   5974 C CE  . LYS   B 1 322 ? 25.00220  15.97874  -27.57441 1.000 29.27093 ? 304  LYS   B CE  1 
ATOM   5975 N NZ  . LYS   B 1 322 ? 26.34789  16.46446  -27.14506 1.000 35.06418 ? 304  LYS   B NZ  1 
ATOM   5976 N N   . GLY   B 1 323 ? 21.91378  12.21811  -24.40504 1.000 9.56618  ? 305  GLY   B N   1 
ATOM   5977 C CA  . GLY   B 1 323 ? 21.07000  12.79890  -23.37058 1.000 12.58142 ? 305  GLY   B CA  1 
ATOM   5978 C C   . GLY   B 1 323 ? 21.43500  12.31095  -21.98052 1.000 12.78812 ? 305  GLY   B C   1 
ATOM   5979 O O   . GLY   B 1 323 ? 21.46843  13.09084  -21.02503 1.000 10.72130 ? 305  GLY   B O   1 
ATOM   5980 N N   . ILE   B 1 324 ? 21.72893  11.01454  -21.85390 1.000 13.91528 ? 306  ILE   B N   1 
ATOM   5981 C CA  . ILE   B 1 324 ? 22.16960  10.46244  -20.57735 1.000 12.96812 ? 306  ILE   B CA  1 
ATOM   5982 C C   . ILE   B 1 324 ? 23.52038  11.04971  -20.17488 1.000 11.82340 ? 306  ILE   B C   1 
ATOM   5983 O O   . ILE   B 1 324 ? 23.73023  11.43249  -19.01758 1.000 11.81067 ? 306  ILE   B O   1 
ATOM   5984 C CB  . ILE   B 1 324 ? 22.22450  8.92649   -20.66510 1.000 13.57282 ? 306  ILE   B CB  1 
ATOM   5985 C CG1 . ILE   B 1 324 ? 20.80768  8.35843   -20.77650 1.000 14.54336 ? 306  ILE   B CG1 1 
ATOM   5986 C CG2 . ILE   B 1 324 ? 22.96660  8.33611   -19.46187 1.000 13.00872 ? 306  ILE   B CG2 1 
ATOM   5987 C CD1 . ILE   B 1 324 ? 20.77017  6.92072   -21.28734 1.000 14.61377 ? 306  ILE   B CD1 1 
ATOM   5988 N N   . ALA   B 1 325 ? 24.46470  11.11567  -21.11954 1.000 14.32499 ? 307  ALA   B N   1 
ATOM   5989 C CA  . ALA   B 1 325 ? 25.76206  11.71082  -20.81505 1.000 15.40764 ? 307  ALA   B CA  1 
ATOM   5990 C C   . ALA   B 1 325 ? 25.62050  13.17338  -20.40346 1.000 13.63259 ? 307  ALA   B C   1 
ATOM   5991 O O   . ALA   B 1 325 ? 26.34017  13.65044  -19.51365 1.000 11.54954 ? 307  ALA   B O   1 
ATOM   5992 C CB  . ALA   B 1 325 ? 26.69700  11.57569  -22.02057 1.000 14.03476 ? 307  ALA   B CB  1 
ATOM   5993 N N   . SER   B 1 326 ? 24.70034  13.90319  -21.04238 1.000 13.78606 ? 308  SER   B N   1 
ATOM   5994 C CA  . SER   B 1 326 ? 24.44887  15.29153  -20.65399 1.000 12.37360 ? 308  SER   B CA  1 
ATOM   5995 C C   . SER   B 1 326 ? 23.98897  15.37229  -19.20068 1.000 8.32551  ? 308  SER   B C   1 
ATOM   5996 O O   . SER   B 1 326 ? 24.51113  16.16913  -18.41371 1.000 8.03747  ? 308  SER   B O   1 
ATOM   5997 C CB  . SER   B 1 326 ? 23.41390  15.91589  -21.60216 1.000 11.34529 ? 308  SER   B CB  1 
ATOM   5998 O OG  . SER   B 1 326 ? 23.03026  17.22450  -21.19136 1.000 14.24429 ? 308  SER   B OG  1 
ATOM   5999 N N   . ALA   B 1 327 ? 23.03220  14.51859  -18.81827 1.000 10.17897 ? 309  ALA   B N   1 
ATOM   6000 C CA  . ALA   B 1 327 ? 22.54729  14.50013  -17.43894 1.000 8.60770  ? 309  ALA   B CA  1 
ATOM   6001 C C   . ALA   B 1 327 ? 23.66233  14.12937  -16.45655 1.000 14.66005 ? 309  ALA   B C   1 
ATOM   6002 O O   . ALA   B 1 327 ? 23.79815  14.75232  -15.39727 1.000 11.23755 ? 309  ALA   B O   1 
ATOM   6003 C CB  . ALA   B 1 327 ? 21.36679  13.52813  -17.32371 1.000 10.60682 ? 309  ALA   B CB  1 
ATOM   6004 N N   . LYS   B 1 328 ? 24.48621  13.13370  -16.79762 1.000 9.41826  ? 310  LYS   B N   1 
ATOM   6005 C CA  . LYS   B 1 328 ? 25.61166  12.77647  -15.92380 1.000 10.05283 ? 310  LYS   B CA  1 
ATOM   6006 C C   . LYS   B 1 328 ? 26.67530  13.87745  -15.86107 1.000 15.00012 ? 310  LYS   B C   1 
ATOM   6007 O O   . LYS   B 1 328 ? 27.40033  13.98356  -14.86309 1.000 15.40130 ? 310  LYS   B O   1 
ATOM   6008 C CB  . LYS   B 1 328 ? 26.26011  11.47322  -16.39916 1.000 11.89741 ? 310  LYS   B CB  1 
ATOM   6009 C CG  . LYS   B 1 328 ? 25.42448  10.21183  -16.23481 1.000 14.36587 ? 310  LYS   B CG  1 
ATOM   6010 C CD  . LYS   B 1 328 ? 26.15194  9.01822   -16.87141 1.000 16.30454 ? 310  LYS   B CD  1 
ATOM   6011 C CE  . LYS   B 1 328 ? 25.41288  7.69416   -16.70970 1.000 24.40829 ? 310  LYS   B CE  1 
ATOM   6012 N NZ  . LYS   B 1 328 ? 25.08587  7.41454   -15.28486 1.000 25.88390 ? 310  LYS   B NZ  1 
ATOM   6013 N N   . THR   B 1 329 ? 26.79486  14.69308  -16.90824 1.000 14.69178 ? 311  THR   B N   1 
ATOM   6014 C CA  . THR   B 1 329 ? 27.84176  15.71305  -16.96818 1.000 10.55036 ? 311  THR   B CA  1 
ATOM   6015 C C   . THR   B 1 329 ? 27.44612  17.00034  -16.24849 1.000 12.69152 ? 311  THR   B C   1 
ATOM   6016 O O   . THR   B 1 329 ? 28.26292  17.59394  -15.53487 1.000 14.27496 ? 311  THR   B O   1 
ATOM   6017 C CB  . THR   B 1 329 ? 28.17508  16.01815  -18.43505 1.000 12.00781 ? 311  THR   B CB  1 
ATOM   6018 O OG1 . THR   B 1 329 ? 28.65465  14.82804  -19.07082 1.000 11.31671 ? 311  THR   B OG1 1 
ATOM   6019 C CG2 . THR   B 1 329 ? 29.21722  17.13979  -18.55952 1.000 12.28704 ? 311  THR   B CG2 1 
ATOM   6020 N N   . TYR   B 1 330 ? 26.20612  17.46318  -16.44917 1.000 9.95431  ? 312  TYR   B N   1 
ATOM   6021 C CA  . TYR   B 1 330 ? 25.76958  18.78457  -16.02275 1.000 10.48387 ? 312  TYR   B CA  1 
ATOM   6022 C C   . TYR   B 1 330 ? 24.77239  18.77082  -14.88004 1.000 10.37114 ? 312  TYR   B C   1 
ATOM   6023 O O   . TYR   B 1 330 ? 24.54748  19.81907  -14.26678 1.000 9.85909  ? 312  TYR   B O   1 
ATOM   6024 C CB  . TYR   B 1 330 ? 25.11484  19.52270  -17.20277 1.000 9.91247  ? 312  TYR   B CB  1 
ATOM   6025 C CG  . TYR   B 1 330 ? 26.03636  19.69796  -18.38351 1.000 14.18887 ? 312  TYR   B CG  1 
ATOM   6026 C CD1 . TYR   B 1 330 ? 27.07034  20.63042  -18.34225 1.000 14.35536 ? 312  TYR   B CD1 1 
ATOM   6027 C CD2 . TYR   B 1 330 ? 25.88358  18.93007  -19.53402 1.000 12.48953 ? 312  TYR   B CD2 1 
ATOM   6028 C CE1 . TYR   B 1 330 ? 27.93263  20.79836  -19.42207 1.000 14.60617 ? 312  TYR   B CE1 1 
ATOM   6029 C CE2 . TYR   B 1 330 ? 26.74186  19.09403  -20.62538 1.000 14.53466 ? 312  TYR   B CE2 1 
ATOM   6030 C CZ  . TYR   B 1 330 ? 27.76395  20.03721  -20.55926 1.000 15.86635 ? 312  TYR   B CZ  1 
ATOM   6031 O OH  . TYR   B 1 330 ? 28.62725  20.21491  -21.63253 1.000 14.16796 ? 312  TYR   B OH  1 
ATOM   6032 N N   . TYR   B 1 331 ? 24.15627  17.62938  -14.58991 1.000 10.67498 ? 313  TYR   B N   1 
ATOM   6033 C CA  . TYR   B 1 331 ? 23.04767  17.62127  -13.64714 1.000 9.69810  ? 313  TYR   B CA  1 
ATOM   6034 C C   . TYR   B 1 331 ? 23.17047  16.47979  -12.64459 1.000 11.79508 ? 313  TYR   B C   1 
ATOM   6035 O O   . TYR   B 1 331 ? 22.15826  15.96424  -12.15924 1.000 11.50786 ? 313  TYR   B O   1 
ATOM   6036 C CB  . TYR   B 1 331 ? 21.71752  17.55687  -14.39678 1.000 8.27895  ? 313  TYR   B CB  1 
ATOM   6037 C CG  . TYR   B 1 331 ? 21.53941  18.69930  -15.38149 1.000 9.82676  ? 313  TYR   B CG  1 
ATOM   6038 C CD1 . TYR   B 1 331 ? 21.34110  20.00077  -14.93127 1.000 11.60009 ? 313  TYR   B CD1 1 
ATOM   6039 C CD2 . TYR   B 1 331 ? 21.59261  18.47614  -16.76010 1.000 10.34818 ? 313  TYR   B CD2 1 
ATOM   6040 C CE1 . TYR   B 1 331 ? 21.19276  21.04841  -15.81340 1.000 14.55647 ? 313  TYR   B CE1 1 
ATOM   6041 C CE2 . TYR   B 1 331 ? 21.43883  19.52431  -17.65423 1.000 10.39737 ? 313  TYR   B CE2 1 
ATOM   6042 C CZ  . TYR   B 1 331 ? 21.24473  20.80321  -17.17183 1.000 16.38876 ? 313  TYR   B CZ  1 
ATOM   6043 O OH  . TYR   B 1 331 ? 21.09550  21.84806  -18.04526 1.000 13.98291 ? 313  TYR   B OH  1 
ATOM   6044 N N   . ARG   B 1 332 ? 24.40553  16.06957  -12.32488 1.000 11.41738 ? 314  ARG   B N   1 
ATOM   6045 C CA  . ARG   B 1 332 ? 24.67248  15.13386  -11.23484 1.000 11.19728 ? 314  ARG   B CA  1 
ATOM   6046 C C   . ARG   B 1 332 ? 23.97947  13.78474  -11.43879 1.000 12.90726 ? 314  ARG   B C   1 
ATOM   6047 O O   . ARG   B 1 332 ? 23.75431  13.05155  -10.47220 1.000 13.06610 ? 314  ARG   B O   1 
ATOM   6048 C CB  . ARG   B 1 332 ? 24.23331  15.73794  -9.89408  1.000 13.97058 ? 314  ARG   B CB  1 
ATOM   6049 C CG  . ARG   B 1 332 ? 24.77828  17.12876  -9.58825  1.000 18.40166 ? 314  ARG   B CG  1 
ATOM   6050 C CD  . ARG   B 1 332 ? 25.14700  17.29506  -8.11534  1.000 25.29042 ? 314  ARG   B CD  1 
ATOM   6051 N NE  . ARG   B 1 332 ? 25.69936  18.61073  -7.79708  1.000 31.70346 ? 314  ARG   B NE  1 
ATOM   6052 C CZ  . ARG   B 1 332 ? 25.12824  19.77935  -8.08369  1.000 41.88413 ? 314  ARG   B CZ  1 
ATOM   6053 N NH1 . ARG   B 1 332 ? 23.93557  19.85698  -8.66113  1.000 43.62420 ? 314  ARG   B NH1 1 
ATOM   6054 N NH2 . ARG   B 1 332 ? 25.76175  20.90550  -7.76647  1.000 47.36368 ? 314  ARG   B NH2 1 
ATOM   6055 N N   . ASP   B 1 333 ? 23.60361  13.44534  -12.67703 1.000 10.07486 ? 315  ASP   B N   1 
ATOM   6056 C CA  . ASP   B 1 333 ? 22.86277  12.21752  -12.95295 1.000 11.55833 ? 315  ASP   B CA  1 
ATOM   6057 C C   . ASP   B 1 333 ? 21.57218  12.14996  -12.13566 1.000 13.29203 ? 315  ASP   B C   1 
ATOM   6058 O O   . ASP   B 1 333 ? 21.14247  11.06785  -11.71777 1.000 11.33318 ? 315  ASP   B O   1 
ATOM   6059 C CB  . ASP   B 1 333 ? 23.73549  10.98340  -12.68427 1.000 17.91290 ? 315  ASP   B CB  1 
ATOM   6060 C CG  . ASP   B 1 333 ? 23.30533  9.76257   -13.47537 1.000 16.03593 ? 315  ASP   B CG  1 
ATOM   6061 O OD1 . ASP   B 1 333 ? 22.41815  9.87480   -14.33232 1.000 16.87677 ? 315  ASP   B OD1 1 
ATOM   6062 O OD2 . ASP   B 1 333 ? 23.84401  8.66978   -13.21681 1.000 17.97813 ? 315  ASP   B OD2 1 
ATOM   6063 N N   . GLU   B 1 334 ? 20.93317  13.30117  -11.90933 1.000 12.06379 ? 316  GLU   B N   1 
ATOM   6064 C CA  . GLU   B 1 334 ? 19.73650  13.38153  -11.08052 1.000 9.38367  ? 316  GLU   B CA  1 
ATOM   6065 C C   . GLU   B 1 334 ? 18.45645  13.56961  -11.90078 1.000 10.67310 ? 316  GLU   B C   1 
ATOM   6066 O O   . GLU   B 1 334 ? 17.40482  13.88679  -11.33468 1.000 10.59246 ? 316  GLU   B O   1 
ATOM   6067 C CB  . GLU   B 1 334 ? 19.91722  14.49246  -10.03036 1.000 14.90774 ? 316  GLU   B CB  1 
ATOM   6068 C CG  . GLU   B 1 334 ? 20.92119  14.05465  -8.94389  1.000 14.48322 ? 316  GLU   B CG  1 
ATOM   6069 C CD  . GLU   B 1 334 ? 21.22666  15.07965  -7.86196  1.000 21.69164 ? 316  GLU   B CD  1 
ATOM   6070 O OE1 . GLU   B 1 334 ? 21.21245  16.30206  -8.12689  1.000 16.66583 ? 316  GLU   B OE1 1 
ATOM   6071 O OE2 . GLU   B 1 334 ? 21.52500  14.64679  -6.72925  1.000 16.93730 ? 316  GLU   B OE2 1 
ATOM   6072 N N   . HIS   B 1 335 ? 18.51441  13.33644  -13.21117 1.000 11.48477 ? 317  HIS   B N   1 
ATOM   6073 C CA  . HIS   B 1 335 ? 17.35705  13.39767  -14.09403 1.000 10.55668 ? 317  HIS   B CA  1 
ATOM   6074 C C   . HIS   B 1 335 ? 16.79576  12.00261  -14.35768 1.000 13.12181 ? 317  HIS   B C   1 
ATOM   6075 O O   . HIS   B 1 335 ? 17.54419  11.02666  -14.49092 1.000 11.87874 ? 317  HIS   B O   1 
ATOM   6076 C CB  . HIS   B 1 335 ? 17.73063  14.02944  -15.43172 1.000 12.39786 ? 317  HIS   B CB  1 
ATOM   6077 C CG  . HIS   B 1 335 ? 17.99802  15.49822  -15.35547 1.000 11.45482 ? 317  HIS   B CG  1 
ATOM   6078 N ND1 . HIS   B 1 335 ? 18.03375  16.30268  -16.47445 1.000 11.77638 ? 317  HIS   B ND1 1 
ATOM   6079 C CD2 . HIS   B 1 335 ? 18.20356  16.31412  -14.29604 1.000 9.38652  ? 317  HIS   B CD2 1 
ATOM   6080 C CE1 . HIS   B 1 335 ? 18.28268  17.54877  -16.10776 1.000 12.41162 ? 317  HIS   B CE1 1 
ATOM   6081 N NE2 . HIS   B 1 335 ? 18.39604  17.57976  -14.79062 1.000 9.75426  ? 317  HIS   B NE2 1 
ATOM   6082 N N   . ILE   B 1 336 ? 15.47225  11.93903  -14.49851 1.000 12.09503 ? 318  ILE   B N   1 
ATOM   6083 C CA  . ILE   B 1 336 ? 14.73901  10.68600  -14.69814 1.000 14.62381 ? 318  ILE   B CA  1 
ATOM   6084 C C   . ILE   B 1 336 ? 14.56013  10.35779  -16.17914 1.000 13.53249 ? 318  ILE   B C   1 
ATOM   6085 O O   . ILE   B 1 336 ? 14.74575  9.21438   -16.60530 1.000 10.35283 ? 318  ILE   B O   1 
ATOM   6086 C CB  . ILE   B 1 336 ? 13.36294  10.77334  -13.99875 1.000 17.73734 ? 318  ILE   B CB  1 
ATOM   6087 C CG1 . ILE   B 1 336 ? 13.51836  10.89235  -12.47989 1.000 14.81387 ? 318  ILE   B CG1 1 
ATOM   6088 C CG2 . ILE   B 1 336 ? 12.48762  9.56069   -14.36825 1.000 15.14173 ? 318  ILE   B CG2 1 
ATOM   6089 C CD1 . ILE   B 1 336 ? 14.09827  9.63646   -11.85743 1.000 18.36158 ? 318  ILE   B CD1 1 
ATOM   6090 N N   . TYR   B 1 337 ? 14.15487  11.34043  -16.98373 1.000 10.24863 ? 319  TYR   B N   1 
ATOM   6091 C CA  . TYR   B 1 337 ? 13.70865  11.08394  -18.34627 1.000 9.45265  ? 319  TYR   B CA  1 
ATOM   6092 C C   . TYR   B 1 337 ? 14.79805  10.55900  -19.29017 1.000 11.31862 ? 319  TYR   B C   1 
ATOM   6093 O O   . TYR   B 1 337 ? 14.46340  9.76803   -20.17822 1.000 11.47177 ? 319  TYR   B O   1 
ATOM   6094 C CB  . TYR   B 1 337 ? 13.06276  12.34789  -18.93092 1.000 11.98559 ? 319  TYR   B CB  1 
ATOM   6095 C CG  . TYR   B 1 337 ? 11.64197  12.57203  -18.44245 1.000 8.51487  ? 319  TYR   B CG  1 
ATOM   6096 C CD1 . TYR   B 1 337 ? 10.75140  11.50396  -18.29748 1.000 14.51979 ? 319  TYR   B CD1 1 
ATOM   6097 C CD2 . TYR   B 1 337 ? 11.20004  13.84917  -18.08984 1.000 7.75355  ? 319  TYR   B CD2 1 
ATOM   6098 C CE1 . TYR   B 1 337 ? 9.43559   11.71118  -17.83163 1.000 11.56345 ? 319  TYR   B CE1 1 
ATOM   6099 C CE2 . TYR   B 1 337 ? 9.90008   14.06152  -17.62312 1.000 13.27835 ? 319  TYR   B CE2 1 
ATOM   6100 C CZ  . TYR   B 1 337 ? 9.02559   12.99344  -17.49743 1.000 12.80022 ? 319  TYR   B CZ  1 
ATOM   6101 O OH  . TYR   B 1 337 ? 7.73847   13.20833  -17.03053 1.000 14.65475 ? 319  TYR   B OH  1 
ATOM   6102 N N   . PRO   B 1 338 ? 16.09020  10.93033  -19.15915 1.000 13.35824 ? 320  PRO   B N   1 
ATOM   6103 C CA  . PRO   B 1 338 ? 17.07942  10.35778  -20.09579 1.000 10.80405 ? 320  PRO   B CA  1 
ATOM   6104 C C   . PRO   B 1 338 ? 17.07029  8.83898   -20.14023 1.000 12.78247 ? 320  PRO   B C   1 
ATOM   6105 O O   . PRO   B 1 338 ? 17.19042  8.25908   -21.22663 1.000 9.83133  ? 320  PRO   B O   1 
ATOM   6106 C CB  . PRO   B 1 338 ? 18.41827  10.89150  -19.57661 1.000 12.08352 ? 320  PRO   B CB  1 
ATOM   6107 C CG  . PRO   B 1 338 ? 18.07358  12.17640  -18.88622 1.000 16.40705 ? 320  PRO   B CG  1 
ATOM   6108 C CD  . PRO   B 1 338 ? 16.73103  11.89043  -18.23349 1.000 13.18639 ? 320  PRO   B CD  1 
ATOM   6109 N N   . TYR   B 1 339 ? 16.94593  8.17975   -18.98188 1.000 9.88798  ? 321  TYR   B N   1 
ATOM   6110 C CA  . TYR   B 1 339 ? 16.82617  6.72678   -18.96466 1.000 12.59618 ? 321  TYR   B CA  1 
ATOM   6111 C C   . TYR   B 1 339 ? 15.46380  6.25796   -19.45841 1.000 14.49518 ? 321  TYR   B C   1 
ATOM   6112 O O   . TYR   B 1 339 ? 15.36846  5.18546   -20.07480 1.000 13.00864 ? 321  TYR   B O   1 
ATOM   6113 C CB  . TYR   B 1 339 ? 17.10003  6.20912   -17.55444 1.000 9.72178  ? 321  TYR   B CB  1 
ATOM   6114 C CG  . TYR   B 1 339 ? 18.47125  6.61096   -17.07135 1.000 11.99902 ? 321  TYR   B CG  1 
ATOM   6115 C CD1 . TYR   B 1 339 ? 19.60978  5.99809   -17.58939 1.000 12.45658 ? 321  TYR   B CD1 1 
ATOM   6116 C CD2 . TYR   B 1 339 ? 18.63780  7.63635   -16.13542 1.000 13.56426 ? 321  TYR   B CD2 1 
ATOM   6117 C CE1 . TYR   B 1 339 ? 20.87732  6.36752   -17.17153 1.000 9.29872  ? 321  TYR   B CE1 1 
ATOM   6118 C CE2 . TYR   B 1 339 ? 19.90838  8.00963   -15.70992 1.000 15.54903 ? 321  TYR   B CE2 1 
ATOM   6119 C CZ  . TYR   B 1 339 ? 21.02227  7.35693   -16.23045 1.000 10.70004 ? 321  TYR   B CZ  1 
ATOM   6120 O OH  . TYR   B 1 339 ? 22.29356  7.69986   -15.83950 1.000 14.53170 ? 321  TYR   B OH  1 
ATOM   6121 N N   A MET   B 1 340 ? 14.39939  7.02677   -19.19605 0.649 11.95652 ? 322  MET   B N   1 
ATOM   6122 N N   B MET   B 1 340 ? 14.40540  7.02971   -19.18283 0.351 11.98698 ? 322  MET   B N   1 
ATOM   6123 C CA  A MET   B 1 340 ? 13.08029  6.65500   -19.70590 0.649 12.89023 ? 322  MET   B CA  1 
ATOM   6124 C CA  B MET   B 1 340 ? 13.07992  6.69688   -19.69862 0.351 12.91029 ? 322  MET   B CA  1 
ATOM   6125 C C   A MET   B 1 340 ? 13.03080  6.72426   -21.22963 0.649 14.64176 ? 322  MET   B C   1 
ATOM   6126 C C   B MET   B 1 340 ? 13.06065  6.71336   -21.22085 0.351 14.56951 ? 322  MET   B C   1 
ATOM   6127 O O   A MET   B 1 340 ? 12.39999  5.87318   -21.87385 0.649 13.82910 ? 322  MET   B O   1 
ATOM   6128 O O   B MET   B 1 340 ? 12.47464  5.82362   -21.85246 0.351 13.84931 ? 322  MET   B O   1 
ATOM   6129 C CB  A MET   B 1 340 ? 11.99962  7.55081   -19.09153 0.649 11.87075 ? 322  MET   B CB  1 
ATOM   6130 C CB  B MET   B 1 340 ? 12.03736  7.67406   -19.14967 0.351 11.88807 ? 322  MET   B CB  1 
ATOM   6131 C CG  A MET   B 1 340 ? 11.91107  7.45577   -17.57009 0.649 14.32051 ? 322  MET   B CG  1 
ATOM   6132 C CG  B MET   B 1 340 ? 11.67258  7.45394   -17.69223 0.351 14.59871 ? 322  MET   B CG  1 
ATOM   6133 S SD  A MET   B 1 340 ? 10.26124  7.84107   -16.95292 0.649 15.42653 ? 322  MET   B SD  1 
ATOM   6134 S SD  B MET   B 1 340 ? 11.01545  5.80261   -17.41130 0.351 15.84070 ? 322  MET   B SD  1 
ATOM   6135 C CE  A MET   B 1 340 ? 10.08099  6.64573   -15.63163 0.649 16.98215 ? 322  MET   B CE  1 
ATOM   6136 C CE  B MET   B 1 340 ? 9.25884   6.14137   -17.36695 0.351 16.42944 ? 322  MET   B CE  1 
ATOM   6137 N N   . TYR   B 1 341 ? 13.68623  7.72611   -21.82803 1.000 8.51621  ? 323  TYR   B N   1 
ATOM   6138 C CA  . TYR   B 1 341 ? 13.76521  7.78590   -23.28783 1.000 11.08097 ? 323  TYR   B CA  1 
ATOM   6139 C C   . TYR   B 1 341 ? 14.43085  6.53943   -23.84962 1.000 15.57702 ? 323  TYR   B C   1 
ATOM   6140 O O   . TYR   B 1 341 ? 13.95010  5.94466   -24.82025 1.000 15.19923 ? 323  TYR   B O   1 
ATOM   6141 C CB  . TYR   B 1 341 ? 14.56820  9.00590   -23.74005 1.000 13.45221 ? 323  TYR   B CB  1 
ATOM   6142 C CG  . TYR   B 1 341 ? 13.80836  10.29793  -23.90832 1.000 13.16746 ? 323  TYR   B CG  1 
ATOM   6143 C CD1 . TYR   B 1 341 ? 12.87758  10.46202  -24.93856 1.000 12.93291 ? 323  TYR   B CD1 1 
ATOM   6144 C CD2 . TYR   B 1 341 ? 14.08409  11.38587  -23.08979 1.000 12.78895 ? 323  TYR   B CD2 1 
ATOM   6145 C CE1 . TYR   B 1 341 ? 12.20846  11.66241  -25.10775 1.000 13.54518 ? 323  TYR   B CE1 1 
ATOM   6146 C CE2 . TYR   B 1 341 ? 13.41812  12.58750  -23.25060 1.000 14.94591 ? 323  TYR   B CE2 1 
ATOM   6147 C CZ  . TYR   B 1 341 ? 12.48566  12.72138  -24.26443 1.000 16.32495 ? 323  TYR   B CZ  1 
ATOM   6148 O OH  . TYR   B 1 341 ? 11.82200  13.92166  -24.41321 1.000 20.09594 ? 323  TYR   B OH  1 
ATOM   6149 N N   . LEU   B 1 342 ? 15.57755  6.16879   -23.27487 1.000 10.16359 ? 324  LEU   B N   1 
ATOM   6150 C CA  . LEU   B 1 342 ? 16.32008  5.00229   -23.73780 1.000 14.12518 ? 324  LEU   B CA  1 
ATOM   6151 C C   . LEU   B 1 342 ? 15.51491  3.72364   -23.53646 1.000 17.78510 ? 324  LEU   B C   1 
ATOM   6152 O O   . LEU   B 1 342 ? 15.45300  2.87083   -24.43359 1.000 12.98844 ? 324  LEU   B O   1 
ATOM   6153 C CB  . LEU   B 1 342 ? 17.66406  4.92729   -23.00363 1.000 11.28876 ? 324  LEU   B CB  1 
ATOM   6154 C CG  . LEU   B 1 342 ? 18.57009  3.72809   -23.31516 1.000 13.63362 ? 324  LEU   B CG  1 
ATOM   6155 C CD1 . LEU   B 1 342 ? 18.93555  3.70232   -24.79259 1.000 16.61648 ? 324  LEU   B CD1 1 
ATOM   6156 C CD2 . LEU   B 1 342 ? 19.82680  3.76635   -22.45704 1.000 8.54793  ? 324  LEU   B CD2 1 
ATOM   6157 N N   . ALA   B 1 343 ? 14.86890  3.58658   -22.37306 1.000 16.18362 ? 325  ALA   B N   1 
ATOM   6158 C CA  . ALA   B 1 343 ? 14.04523  2.40918   -22.11564 1.000 15.61936 ? 325  ALA   B CA  1 
ATOM   6159 C C   . ALA   B 1 343 ? 12.94931  2.27287   -23.15676 1.000 18.82495 ? 325  ALA   B C   1 
ATOM   6160 O O   . ALA   B 1 343 ? 12.65839  1.16260   -23.62212 1.000 14.82652 ? 325  ALA   B O   1 
ATOM   6161 C CB  . ALA   B 1 343 ? 13.43549  2.47777   -20.71156 1.000 10.02035 ? 325  ALA   B CB  1 
ATOM   6162 N N   . GLY   B 1 344 ? 12.32876  3.39571   -23.53040 1.000 15.55793 ? 326  GLY   B N   1 
ATOM   6163 C CA  . GLY   B 1 344 ? 11.27862  3.36313   -24.53774 1.000 16.16027 ? 326  GLY   B CA  1 
ATOM   6164 C C   . GLY   B 1 344 ? 11.77964  2.89805   -25.89261 1.000 22.12529 ? 326  GLY   B C   1 
ATOM   6165 O O   . GLY   B 1 344 ? 11.10374  2.13315   -26.58638 1.000 19.75310 ? 326  GLY   B O   1 
ATOM   6166 N N   . TYR   B 1 345 ? 12.97212  3.34659   -26.28710 1.000 14.38723 ? 327  TYR   B N   1 
ATOM   6167 C CA  . TYR   B 1 345 ? 13.53108  2.89622   -27.55828 1.000 14.57311 ? 327  TYR   B CA  1 
ATOM   6168 C C   . TYR   B 1 345 ? 13.76021  1.38754   -27.53515 1.000 19.33420 ? 327  TYR   B C   1 
ATOM   6169 O O   . TYR   B 1 345 ? 13.38108  0.67257   -28.47168 1.000 18.32142 ? 327  TYR   B O   1 
ATOM   6170 C CB  . TYR   B 1 345 ? 14.82819  3.65742   -27.86257 1.000 16.74211 ? 327  TYR   B CB  1 
ATOM   6171 C CG  . TYR   B 1 345 ? 15.75716  2.98561   -28.86921 1.000 22.99257 ? 327  TYR   B CG  1 
ATOM   6172 C CD1 . TYR   B 1 345 ? 16.67613  2.01043   -28.47472 1.000 22.80411 ? 327  TYR   B CD1 1 
ATOM   6173 C CD2 . TYR   B 1 345 ? 15.69562  3.32147   -30.22345 1.000 34.37537 ? 327  TYR   B CD2 1 
ATOM   6174 C CE1 . TYR   B 1 345 ? 17.51797  1.39839   -29.40074 1.000 29.34586 ? 327  TYR   B CE1 1 
ATOM   6175 C CE2 . TYR   B 1 345 ? 16.53436  2.71866   -31.15617 1.000 25.33567 ? 327  TYR   B CE2 1 
ATOM   6176 C CZ  . TYR   B 1 345 ? 17.44036  1.75725   -30.73765 1.000 36.41410 ? 327  TYR   B CZ  1 
ATOM   6177 O OH  . TYR   B 1 345 ? 18.27034  1.15420   -31.65931 1.000 53.86175 ? 327  TYR   B OH  1 
ATOM   6178 N N   . HIS   B 1 346 ? 14.35327  0.88256   -26.45052 1.000 14.53417 ? 328  HIS   B N   1 
ATOM   6179 C CA  . HIS   B 1 346 ? 14.57936  -0.55560  -26.33064 1.000 17.19621 ? 328  HIS   B CA  1 
ATOM   6180 C C   . HIS   B 1 346 ? 13.26477  -1.31690  -26.26821 1.000 23.49514 ? 328  HIS   B C   1 
ATOM   6181 O O   . HIS   B 1 346 ? 13.13580  -2.38995  -26.86945 1.000 17.26976 ? 328  HIS   B O   1 
ATOM   6182 C CB  . HIS   B 1 346 ? 15.42457  -0.85436  -25.09928 1.000 13.78296 ? 328  HIS   B CB  1 
ATOM   6183 C CG  . HIS   B 1 346 ? 16.86947  -0.50530  -25.26904 1.000 17.73226 ? 328  HIS   B CG  1 
ATOM   6184 N ND1 . HIS   B 1 346 ? 17.61974  -0.94879  -26.33592 1.000 18.21354 ? 328  HIS   B ND1 1 
ATOM   6185 C CD2 . HIS   B 1 346 ? 17.70065  0.25043   -24.51238 1.000 18.97946 ? 328  HIS   B CD2 1 
ATOM   6186 C CE1 . HIS   B 1 346 ? 18.85229  -0.48595  -26.22834 1.000 21.03022 ? 328  HIS   B CE1 1 
ATOM   6187 N NE2 . HIS   B 1 346 ? 18.92937  0.24170   -25.12809 1.000 18.81828 ? 328  HIS   B NE2 1 
ATOM   6188 N N   . CYS   B 1 347 ? 12.27166  -0.76977  -25.55416 1.000 20.53669 ? 329  CYS   B N   1 
ATOM   6189 C CA  . CYS   B 1 347 ? 10.96740  -1.42328  -25.48087 1.000 17.45509 ? 329  CYS   B CA  1 
ATOM   6190 C C   . CYS   B 1 347 ? 10.34167  -1.54859  -26.86676 1.000 23.68945 ? 329  CYS   B C   1 
ATOM   6191 O O   . CYS   B 1 347 ? 9.80108   -2.60486  -27.21871 1.000 22.50101 ? 329  CYS   B O   1 
ATOM   6192 C CB  . CYS   B 1 347 ? 10.05361  -0.65825  -24.52025 1.000 16.01444 ? 329  CYS   B CB  1 
ATOM   6193 S SG  . CYS   B 1 347 ? 8.45560   -1.43076  -24.25694 1.000 29.64117 ? 329  CYS   B SG  1 
ATOM   6194 N N   . ARG   B 1 348 ? 10.45978  -0.50314  -27.69100 1.000 19.84447 ? 330  ARG   B N   1 
ATOM   6195 C CA  . ARG   B 1 348 ? 9.89491   -0.55452  -29.03721 1.000 29.89020 ? 330  ARG   B CA  1 
ATOM   6196 C C   . ARG   B 1 348 ? 10.58151  -1.59676  -29.90822 1.000 28.22271 ? 330  ARG   B C   1 
ATOM   6197 O O   . ARG   B 1 348 ? 9.94349   -2.17573  -30.79325 1.000 25.68169 ? 330  ARG   B O   1 
ATOM   6198 C CB  . ARG   B 1 348 ? 9.96022   0.82443   -29.70185 1.000 23.43385 ? 330  ARG   B CB  1 
ATOM   6199 C CG  . ARG   B 1 348 ? 9.01469   1.84341   -29.07501 1.000 31.69784 ? 330  ARG   B CG  1 
ATOM   6200 C CD  . ARG   B 1 348 ? 8.94671   3.14299   -29.87428 1.000 24.82722 ? 330  ARG   B CD  1 
ATOM   6201 N NE  . ARG   B 1 348 ? 10.16704  3.93459   -29.77012 1.000 27.22216 ? 330  ARG   B NE  1 
ATOM   6202 C CZ  . ARG   B 1 348 ? 10.43229  4.74317   -28.75288 1.000 21.47502 ? 330  ARG   B CZ  1 
ATOM   6203 N NH1 . ARG   B 1 348 ? 9.59651   4.86437   -27.73353 1.000 25.12047 ? 330  ARG   B NH1 1 
ATOM   6204 N NH2 . ARG   B 1 348 ? 11.56283  5.44106   -28.75416 1.000 25.30710 ? 330  ARG   B NH2 1 
ATOM   6205 N N   . ASN   B 1 349 ? 11.86661  -1.85405  -29.68303 1.000 25.17121 ? 331  ASN   B N   1 
ATOM   6206 C CA  . ASN   B 1 349 ? 12.57004  -2.90691  -30.40355 1.000 29.03034 ? 331  ASN   B CA  1 
ATOM   6207 C C   . ASN   B 1 349 ? 12.51348  -4.25307  -29.68899 1.000 26.50358 ? 331  ASN   B C   1 
ATOM   6208 O O   . ASN   B 1 349 ? 13.21689  -5.18406  -30.09315 1.000 21.84550 ? 331  ASN   B O   1 
ATOM   6209 C CB  . ASN   B 1 349 ? 14.02314  -2.49681  -30.64368 1.000 24.83405 ? 331  ASN   B CB  1 
ATOM   6210 C CG  . ASN   B 1 349 ? 14.13383  -1.29839  -31.56320 1.000 33.24759 ? 331  ASN   B CG  1 
ATOM   6211 O OD1 . ASN   B 1 349 ? 13.50807  -1.26208  -32.62328 1.000 35.97136 ? 331  ASN   B OD1 1 
ATOM   6212 N ND2 . ASN   B 1 349 ? 14.93352  -0.31187  -31.16685 1.000 41.81247 ? 331  ASN   B ND2 1 
ATOM   6213 N N   . ARG   B 1 350 ? 11.70702  -4.36246  -28.62961 1.000 20.83540 ? 332  ARG   B N   1 
ATOM   6214 C CA  . ARG   B 1 350 ? 11.49320  -5.60808  -27.88731 1.000 20.47077 ? 332  ARG   B CA  1 
ATOM   6215 C C   . ARG   B 1 350 ? 12.78222  -6.15699  -27.26685 1.000 30.35762 ? 332  ARG   B C   1 
ATOM   6216 O O   . ARG   B 1 350 ? 12.91500  -7.36992  -27.06727 1.000 23.07129 ? 332  ARG   B O   1 
ATOM   6217 C CB  . ARG   B 1 350 ? 10.83477  -6.67851  -28.77258 1.000 25.38207 ? 332  ARG   B CB  1 
ATOM   6218 C CG  . ARG   B 1 350 ? 9.51508   -6.26160  -29.42325 1.000 26.71321 ? 332  ARG   B CG  1 
ATOM   6219 C CD  . ARG   B 1 350 ? 8.65100   -5.41147  -28.49125 1.000 32.11506 ? 332  ARG   B CD  1 
ATOM   6220 N NE  . ARG   B 1 350 ? 7.86291   -6.21373  -27.56116 1.000 39.83955 ? 332  ARG   B NE  1 
ATOM   6221 C CZ  . ARG   B 1 350 ? 7.04801   -5.70885  -26.64401 1.000 35.35348 ? 332  ARG   B CZ  1 
ATOM   6222 N NH1 . ARG   B 1 350 ? 6.89906   -4.40214  -26.49623 1.000 35.37651 ? 332  ARG   B NH1 1 
ATOM   6223 N NH2 . ARG   B 1 350 ? 6.37909   -6.53497  -25.84289 1.000 35.09888 ? 332  ARG   B NH2 1 
ATOM   6224 N N   . ASN   B 1 351 ? 13.74683  -5.29175  -26.94004 1.000 20.41131 ? 333  ASN   B N   1 
ATOM   6225 C CA  . ASN   B 1 351 ? 14.95416  -5.74306  -26.23881 1.000 24.64710 ? 333  ASN   B CA  1 
ATOM   6226 C C   . ASN   B 1 351 ? 14.65755  -5.68303  -24.74940 1.000 19.99659 ? 333  ASN   B C   1 
ATOM   6227 O O   . ASN   B 1 351 ? 14.87515  -4.66558  -24.09180 1.000 14.80801 ? 333  ASN   B O   1 
ATOM   6228 C CB  . ASN   B 1 351 ? 16.17153  -4.90357  -26.60940 1.000 25.84108 ? 333  ASN   B CB  1 
ATOM   6229 C CG  . ASN   B 1 351 ? 17.49185  -5.51367  -26.10124 1.000 30.84324 ? 333  ASN   B CG  1 
ATOM   6230 O OD1 . ASN   B 1 351 ? 17.54605  -6.14938  -25.03757 1.000 17.95021 ? 333  ASN   B OD1 1 
ATOM   6231 N ND2 . ASN   B 1 351 ? 18.55800  -5.32157  -26.87098 1.000 30.66141 ? 333  ASN   B ND2 1 
ATOM   6232 N N   . VAL   B 1 352 ? 14.16308  -6.80123  -24.21241 1.000 18.37968 ? 334  VAL   B N   1 
ATOM   6233 C CA  . VAL   B 1 352 ? 13.66584  -6.82161  -22.83887 1.000 16.34747 ? 334  VAL   B CA  1 
ATOM   6234 C C   . VAL   B 1 352 ? 14.78560  -6.49675  -21.86055 1.000 17.78947 ? 334  VAL   B C   1 
ATOM   6235 O O   . VAL   B 1 352 ? 14.61327  -5.68877  -20.94058 1.000 13.46854 ? 334  VAL   B O   1 
ATOM   6236 C CB  . VAL   B 1 352 ? 13.01103  -8.18080  -22.52740 1.000 19.67774 ? 334  VAL   B CB  1 
ATOM   6237 C CG1 . VAL   B 1 352 ? 12.38886  -8.17611  -21.13402 1.000 16.90972 ? 334  VAL   B CG1 1 
ATOM   6238 C CG2 . VAL   B 1 352 ? 11.92973  -8.48323  -23.55382 1.000 16.38381 ? 334  VAL   B CG2 1 
ATOM   6239 N N   . ARG   B 1 353 ? 15.94689  -7.13025  -22.04273 1.000 14.11909 ? 335  ARG   B N   1 
ATOM   6240 C CA  . ARG   B 1 353 ? 17.06867  -6.91520  -21.13548 1.000 16.33457 ? 335  ARG   B CA  1 
ATOM   6241 C C   . ARG   B 1 353 ? 17.46897  -5.44496  -21.07983 1.000 12.78301 ? 335  ARG   B C   1 
ATOM   6242 O O   . ARG   B 1 353 ? 17.63829  -4.88404  -19.99190 1.000 12.05727 ? 335  ARG   B O   1 
ATOM   6243 C CB  . ARG   B 1 353 ? 18.25312  -7.78010  -21.56714 1.000 10.33908 ? 335  ARG   B CB  1 
ATOM   6244 C CG  . ARG   B 1 353 ? 19.56665  -7.49211  -20.85307 1.000 14.70681 ? 335  ARG   B CG  1 
ATOM   6245 C CD  . ARG   B 1 353 ? 20.65320  -8.41151  -21.41470 1.000 20.76381 ? 335  ARG   B CD  1 
ATOM   6246 N NE  . ARG   B 1 353 ? 20.50485  -9.78077  -20.92785 1.000 24.26913 ? 335  ARG   B NE  1 
ATOM   6247 C CZ  . ARG   B 1 353 ? 19.87610  -10.76090 -21.57214 1.000 24.22811 ? 335  ARG   B CZ  1 
ATOM   6248 N NH1 . ARG   B 1 353 ? 19.31679  -10.57269 -22.76402 1.000 16.26186 ? 335  ARG   B NH1 1 
ATOM   6249 N NH2 . ARG   B 1 353 ? 19.78473  -11.95482 -20.99642 1.000 20.00676 ? 335  ARG   B NH2 1 
ATOM   6250 N N   . GLU   B 1 354 ? 17.64264  -4.80181  -22.24362 1.000 11.64772 ? 336  GLU   B N   1 
ATOM   6251 C CA  . GLU   B 1 354 ? 18.11339  -3.41748  -22.23109 1.000 15.97670 ? 336  GLU   B CA  1 
ATOM   6252 C C   . GLU   B 1 354 ? 17.02800  -2.45264  -21.75919 1.000 13.64129 ? 336  GLU   B C   1 
ATOM   6253 O O   . GLU   B 1 354 ? 17.33555  -1.42072  -21.14564 1.000 11.29708 ? 336  GLU   B O   1 
ATOM   6254 C CB  . GLU   B 1 354 ? 18.61387  -3.00079  -23.61258 1.000 17.78111 ? 336  GLU   B CB  1 
ATOM   6255 C CG  . GLU   B 1 354 ? 19.93132  -3.67932  -24.02136 1.000 21.47984 ? 336  GLU   B CG  1 
ATOM   6256 C CD  . GLU   B 1 354 ? 21.04167  -3.54256  -22.98081 1.000 32.69188 ? 336  GLU   B CD  1 
ATOM   6257 O OE1 . GLU   B 1 354 ? 21.65953  -4.59102  -22.64555 1.000 42.09287 ? 336  GLU   B OE1 1 
ATOM   6258 O OE2 . GLU   B 1 354 ? 21.29710  -2.42228  -22.49229 1.000 32.18030 ? 336  GLU   B OE2 1 
ATOM   6259 N N   . ALA   B 1 355 ? 15.76086  -2.74872  -22.04596 1.000 17.19116 ? 337  ALA   B N   1 
ATOM   6260 C CA  . ALA   B 1 355 ? 14.69510  -1.93378  -21.46806 1.000 13.92652 ? 337  ALA   B CA  1 
ATOM   6261 C C   . ALA   B 1 355 ? 14.68401  -2.05162  -19.94715 1.000 14.00298 ? 337  ALA   B C   1 
ATOM   6262 O O   . ALA   B 1 355 ? 14.58550  -1.03822  -19.24481 1.000 16.03589 ? 337  ALA   B O   1 
ATOM   6263 C CB  . ALA   B 1 355 ? 13.33948  -2.32211  -22.06474 1.000 11.71412 ? 337  ALA   B CB  1 
ATOM   6264 N N   . LEU   B 1 356 ? 14.81258  -3.27434  -19.41184 1.000 11.01818 ? 338  LEU   B N   1 
ATOM   6265 C CA  . LEU   B 1 356 ? 14.81417  -3.43348  -17.95494 1.000 11.67216 ? 338  LEU   B CA  1 
ATOM   6266 C C   . LEU   B 1 356 ? 16.03198  -2.76702  -17.31670 1.000 16.64459 ? 338  LEU   B C   1 
ATOM   6267 O O   . LEU   B 1 356 ? 15.93556  -2.21062  -16.21163 1.000 10.77930 ? 338  LEU   B O   1 
ATOM   6268 C CB  . LEU   B 1 356 ? 14.76913  -4.91419  -17.56506 1.000 11.95380 ? 338  LEU   B CB  1 
ATOM   6269 C CG  . LEU   B 1 356 ? 13.50635  -5.72092  -17.87655 1.000 16.35679 ? 338  LEU   B CG  1 
ATOM   6270 C CD1 . LEU   B 1 356 ? 13.72591  -7.20362  -17.58628 1.000 15.53334 ? 338  LEU   B CD1 1 
ATOM   6271 C CD2 . LEU   B 1 356 ? 12.32015  -5.19331  -17.08559 1.000 12.22126 ? 338  LEU   B CD2 1 
ATOM   6272 N N   . GLN   B 1 357 ? 17.18987  -2.83320  -17.98232 1.000 15.48727 ? 339  GLN   B N   1 
ATOM   6273 C CA  . GLN   B 1 357 ? 18.37475  -2.14767  -17.47233 1.000 12.09920 ? 339  GLN   B CA  1 
ATOM   6274 C C   . GLN   B 1 357 ? 18.13910  -0.64464  -17.37497 1.000 15.91371 ? 339  GLN   B C   1 
ATOM   6275 O O   . GLN   B 1 357 ? 18.49872  -0.01923  -16.37154 1.000 15.15303 ? 339  GLN   B O   1 
ATOM   6276 C CB  . GLN   B 1 357 ? 19.58936  -2.43556  -18.36388 1.000 14.43602 ? 339  GLN   B CB  1 
ATOM   6277 C CG  . GLN   B 1 357 ? 20.85900  -1.62616  -18.02270 1.000 14.58308 ? 339  GLN   B CG  1 
ATOM   6278 C CD  . GLN   B 1 357 ? 21.49440  -1.98753  -16.67721 1.000 20.14398 ? 339  GLN   B CD  1 
ATOM   6279 O OE1 . GLN   B 1 357 ? 22.42661  -2.80110  -16.61596 1.000 22.21536 ? 339  GLN   B OE1 1 
ATOM   6280 N NE2 . GLN   B 1 357 ? 21.01436  -1.36507  -15.59852 1.000 18.35608 ? 339  GLN   B NE2 1 
ATOM   6281 N N   . ALA   B 1 358 ? 17.51967  -0.04958  -18.39779 1.000 13.04079 ? 340  ALA   B N   1 
ATOM   6282 C CA  . ALA   B 1 358 ? 17.29229  1.39472   -18.37557 1.000 12.58042 ? 340  ALA   B CA  1 
ATOM   6283 C C   . ALA   B 1 358 ? 16.25445  1.78522   -17.32027 1.000 12.00091 ? 340  ALA   B C   1 
ATOM   6284 O O   . ALA   B 1 358 ? 16.39410  2.82500   -16.66918 1.000 15.86173 ? 340  ALA   B O   1 
ATOM   6285 C CB  . ALA   B 1 358 ? 16.88697  1.88755   -19.76952 1.000 10.22093 ? 340  ALA   B CB  1 
ATOM   6286 N N   . TRP   B 1 359 ? 15.21423  0.96430   -17.11666 1.000 11.51468 ? 341  TRP   B N   1 
ATOM   6287 C CA  . TRP   B 1 359 ? 14.25866  1.26438   -16.04759 1.000 13.29244 ? 341  TRP   B CA  1 
ATOM   6288 C C   . TRP   B 1 359 ? 14.88013  1.09082   -14.67087 1.000 13.04259 ? 341  TRP   B C   1 
ATOM   6289 O O   . TRP   B 1 359 ? 14.54506  1.83383   -13.74359 1.000 13.52244 ? 341  TRP   B O   1 
ATOM   6290 C CB  . TRP   B 1 359 ? 13.01469  0.38545   -16.17055 1.000 11.49177 ? 341  TRP   B CB  1 
ATOM   6291 C CG  . TRP   B 1 359 ? 12.12783  0.87545   -17.21113 1.000 14.69526 ? 341  TRP   B CG  1 
ATOM   6292 C CD1 . TRP   B 1 359 ? 11.79118  2.17820   -17.46514 1.000 13.88662 ? 341  TRP   B CD1 1 
ATOM   6293 C CD2 . TRP   B 1 359 ? 11.48153  0.09036   -18.20002 1.000 12.21515 ? 341  TRP   B CD2 1 
ATOM   6294 N NE1 . TRP   B 1 359 ? 10.95082  2.24205   -18.54613 1.000 14.64241 ? 341  TRP   B NE1 1 
ATOM   6295 C CE2 . TRP   B 1 359 ? 10.75027  0.97122   -19.01952 1.000 16.49835 ? 341  TRP   B CE2 1 
ATOM   6296 C CE3 . TRP   B 1 359 ? 11.44649  -1.27734  -18.47327 1.000 13.79361 ? 341  TRP   B CE3 1 
ATOM   6297 C CZ2 . TRP   B 1 359 ? 9.99367   0.52853   -20.08723 1.000 18.29967 ? 341  TRP   B CZ2 1 
ATOM   6298 C CZ3 . TRP   B 1 359 ? 10.69423  -1.71437  -19.52939 1.000 16.20336 ? 341  TRP   B CZ3 1 
ATOM   6299 C CH2 . TRP   B 1 359 ? 9.97803   -0.81531  -20.32770 1.000 24.15237 ? 341  TRP   B CH2 1 
ATOM   6300 N N   . ALA   B 1 360 ? 15.75206  0.08953   -14.50332 1.000 16.74707 ? 342  ALA   B N   1 
ATOM   6301 C CA  . ALA   B 1 360 ? 16.51687  -0.01532  -13.26393 1.000 18.26380 ? 342  ALA   B CA  1 
ATOM   6302 C C   . ALA   B 1 360 ? 17.34940  1.24069   -13.03605 1.000 16.35875 ? 342  ALA   B C   1 
ATOM   6303 O O   . ALA   B 1 360 ? 17.36760  1.78468   -11.92864 1.000 14.11862 ? 342  ALA   B O   1 
ATOM   6304 C CB  . ALA   B 1 360 ? 17.41453  -1.26139  -13.27699 1.000 11.99428 ? 342  ALA   B CB  1 
ATOM   6305 N N   . ASP   B 1 361 ? 18.01779  1.73658   -14.08175 1.000 18.62060 ? 343  ASP   B N   1 
ATOM   6306 C CA  . ASP   B 1 361 ? 18.77402  2.98045   -13.94252 1.000 16.07435 ? 343  ASP   B CA  1 
ATOM   6307 C C   . ASP   B 1 361 ? 17.86109  4.14166   -13.56585 1.000 13.25214 ? 343  ASP   B C   1 
ATOM   6308 O O   . ASP   B 1 361 ? 18.23655  4.99506   -12.75090 1.000 16.82499 ? 343  ASP   B O   1 
ATOM   6309 C CB  . ASP   B 1 361 ? 19.51469  3.30392   -15.23737 1.000 12.69246 ? 343  ASP   B CB  1 
ATOM   6310 C CG  . ASP   B 1 361 ? 20.65220  2.34260   -15.51151 1.000 24.69102 ? 343  ASP   B CG  1 
ATOM   6311 O OD1 . ASP   B 1 361 ? 21.08085  1.64883   -14.56563 1.000 18.18322 ? 343  ASP   B OD1 1 
ATOM   6312 O OD2 . ASP   B 1 361 ? 21.11166  2.27604   -16.67000 1.000 16.90513 ? 343  ASP   B OD2 1 
ATOM   6313 N N   . THR   B 1 362 ? 16.66988  4.19982   -14.16736 1.000 14.28378 ? 344  THR   B N   1 
ATOM   6314 C CA  . THR   B 1 362 ? 15.70732  5.24150   -13.81442 1.000 19.73016 ? 344  THR   B CA  1 
ATOM   6315 C C   . THR   B 1 362 ? 15.39755  5.20937   -12.32727 1.000 14.91654 ? 344  THR   B C   1 
ATOM   6316 O O   . THR   B 1 362 ? 15.34132  6.25471   -11.67037 1.000 13.04595 ? 344  THR   B O   1 
ATOM   6317 C CB  . THR   B 1 362 ? 14.42151  5.06071   -14.62103 1.000 18.97148 ? 344  THR   B CB  1 
ATOM   6318 O OG1 . THR   B 1 362 ? 14.73672  4.91673   -16.00908 1.000 19.53457 ? 344  THR   B OG1 1 
ATOM   6319 C CG2 . THR   B 1 362 ? 13.51183  6.23870   -14.44988 1.000 17.45237 ? 344  THR   B CG2 1 
ATOM   6320 N N   . ALA   B 1 363 ? 15.21402  4.00507   -11.77948 1.000 15.08935 ? 345  ALA   B N   1 
ATOM   6321 C CA  . ALA   B 1 363 ? 14.85542  3.84784   -10.37453 1.000 14.18065 ? 345  ALA   B CA  1 
ATOM   6322 C C   . ALA   B 1 363 ? 16.00614  4.22225   -9.44467  1.000 15.85469 ? 345  ALA   B C   1 
ATOM   6323 O O   . ALA   B 1 363 ? 15.77262  4.72408   -8.33784  1.000 19.08718 ? 345  ALA   B O   1 
ATOM   6324 C CB  . ALA   B 1 363 ? 14.41499  2.40607   -10.11488 1.000 13.49902 ? 345  ALA   B CB  1 
ATOM   6325 N N   . THR   B 1 364 ? 17.25280  3.95251   -9.84136  1.000 15.93866 ? 346  THR   B N   1 
ATOM   6326 C CA  . THR   B 1 364 ? 18.35070  4.37890   -8.97710  1.000 18.05522 ? 346  THR   B CA  1 
ATOM   6327 C C   . THR   B 1 364 ? 18.48145  5.89852   -8.90704  1.000 21.30938 ? 346  THR   B C   1 
ATOM   6328 O O   . THR   B 1 364 ? 19.15841  6.40683   -8.00347  1.000 18.46474 ? 346  THR   B O   1 
ATOM   6329 C CB  . THR   B 1 364 ? 19.68527  3.75659   -9.42123  1.000 26.73107 ? 346  THR   B CB  1 
ATOM   6330 O OG1 . THR   B 1 364 ? 20.13789  4.35000   -10.64641 1.000 26.70447 ? 346  THR   B OG1 1 
ATOM   6331 C CG2 . THR   B 1 364 ? 19.52379  2.26860   -9.61678  1.000 23.98681 ? 346  THR   B CG2 1 
ATOM   6332 N N   . VAL   B 1 365 ? 17.84419  6.63642   -9.81058  1.000 13.26717 ? 347  VAL   B N   1 
ATOM   6333 C CA  . VAL   B 1 365 ? 17.77601  8.09501   -9.67053  1.000 16.86803 ? 347  VAL   B CA  1 
ATOM   6334 C C   . VAL   B 1 365 ? 16.61471  8.50645   -8.77165  1.000 10.99669 ? 347  VAL   B C   1 
ATOM   6335 O O   . VAL   B 1 365 ? 16.77590  9.33731   -7.87492  1.000 13.85376 ? 347  VAL   B O   1 
ATOM   6336 C CB  . VAL   B 1 365 ? 17.66858  8.77231   -11.05232 1.000 14.38265 ? 347  VAL   B CB  1 
ATOM   6337 C CG1 . VAL   B 1 365 ? 17.47541  10.29855  -10.89194 1.000 9.53352  ? 347  VAL   B CG1 1 
ATOM   6338 C CG2 . VAL   B 1 365 ? 18.88433  8.45490   -11.90221 1.000 10.59317 ? 347  VAL   B CG2 1 
ATOM   6339 N N   . ILE   B 1 366 ? 15.42889  7.92869   -8.99080  1.000 11.52024 ? 348  ILE   B N   1 
ATOM   6340 C CA  . ILE   B 1 366 ? 14.26752  8.32536   -8.19752  1.000 11.91832 ? 348  ILE   B CA  1 
ATOM   6341 C C   . ILE   B 1 366 ? 14.40936  7.90384   -6.74098  1.000 13.84063 ? 348  ILE   B C   1 
ATOM   6342 O O   . ILE   B 1 366 ? 13.76853  8.50007   -5.87121  1.000 13.91177 ? 348  ILE   B O   1 
ATOM   6343 C CB  . ILE   B 1 366 ? 12.96217  7.76530   -8.80656  1.000 12.07387 ? 348  ILE   B CB  1 
ATOM   6344 C CG1 . ILE   B 1 366 ? 11.76520  8.64322   -8.40593  1.000 14.61809 ? 348  ILE   B CG1 1 
ATOM   6345 C CG2 . ILE   B 1 366 ? 12.73736  6.30820   -8.40237  1.000 12.26828 ? 348  ILE   B CG2 1 
ATOM   6346 C CD1 . ILE   B 1 366 ? 11.73905  9.98955   -9.08627  1.000 14.25418 ? 348  ILE   B CD1 1 
ATOM   6347 N N   . GLN   B 1 367 ? 15.26211  6.91088   -6.44529  1.000 11.52921 ? 349  GLN   B N   1 
ATOM   6348 C CA  . GLN   B 1 367 ? 15.39304  6.41624   -5.07169  1.000 15.70947 ? 349  GLN   B CA  1 
ATOM   6349 C C   . GLN   B 1 367 ? 15.78944  7.51457   -4.08948  1.000 16.73274 ? 349  GLN   B C   1 
ATOM   6350 O O   . GLN   B 1 367 ? 15.36113  7.48115   -2.92907  1.000 16.60517 ? 349  GLN   B O   1 
ATOM   6351 C CB  . GLN   B 1 367 ? 16.41021  5.26831   -5.00556  1.000 13.76712 ? 349  GLN   B CB  1 
ATOM   6352 C CG  . GLN   B 1 367 ? 17.87599  5.71191   -5.00353  1.000 18.03608 ? 349  GLN   B CG  1 
ATOM   6353 C CD  . GLN   B 1 367 ? 18.84577  4.53953   -4.97730  1.000 27.75325 ? 349  GLN   B CD  1 
ATOM   6354 O OE1 . GLN   B 1 367 ? 18.75567  3.66867   -4.11800  1.000 21.31735 ? 349  GLN   B OE1 1 
ATOM   6355 N NE2 . GLN   B 1 367 ? 19.77303  4.51146   -5.93044  1.000 28.15699 ? 349  GLN   B NE2 1 
ATOM   6356 N N   . ASP   B 1 368 ? 16.57732  8.50209   -4.53013  1.000 13.33346 ? 350  ASP   B N   1 
ATOM   6357 C CA  . ASP   B 1 368 ? 17.04371  9.59056   -3.67270  1.000 16.57265 ? 350  ASP   B CA  1 
ATOM   6358 C C   . ASP   B 1 368 ? 16.13319  10.82663  -3.71926  1.000 18.17748 ? 350  ASP   B C   1 
ATOM   6359 O O   . ASP   B 1 368 ? 16.55002  11.91752  -3.31203  1.000 19.17606 ? 350  ASP   B O   1 
ATOM   6360 C CB  . ASP   B 1 368 ? 18.48510  9.96003   -4.04244  1.000 17.64962 ? 350  ASP   B CB  1 
ATOM   6361 C CG  . ASP   B 1 368 ? 19.17457  10.79089  -2.96545  1.000 29.71017 ? 350  ASP   B CG  1 
ATOM   6362 O OD1 . ASP   B 1 368 ? 19.07095  10.42409  -1.77757  1.000 25.60566 ? 350  ASP   B OD1 1 
ATOM   6363 O OD2 . ASP   B 1 368 ? 19.81008  11.81923  -3.30274  1.000 30.85014 ? 350  ASP   B OD2 1 
ATOM   6364 N N   . TYR   B 1 369 ? 14.90162  10.67985  -4.19118  1.000 12.77628 ? 351  TYR   B N   1 
ATOM   6365 C CA  . TYR   B 1 369 ? 13.89389  11.72645  -4.10945  1.000 14.38642 ? 351  TYR   B CA  1 
ATOM   6366 C C   . TYR   B 1 369 ? 12.86071  11.34377  -3.05852  1.000 13.17134 ? 351  TYR   B C   1 
ATOM   6367 O O   . TYR   B 1 369 ? 12.78474  10.18691  -2.63461  1.000 14.90334 ? 351  TYR   B O   1 
ATOM   6368 C CB  . TYR   B 1 369 ? 13.22472  11.94507  -5.47207  1.000 13.35929 ? 351  TYR   B CB  1 
ATOM   6369 C CG  . TYR   B 1 369 ? 14.09169  12.74235  -6.43496  1.000 14.79878 ? 351  TYR   B CG  1 
ATOM   6370 C CD1 . TYR   B 1 369 ? 14.06178  14.13465  -6.42846  1.000 12.31307 ? 351  TYR   B CD1 1 
ATOM   6371 C CD2 . TYR   B 1 369 ? 14.93752  12.10026  -7.34289  1.000 10.11657 ? 351  TYR   B CD2 1 
ATOM   6372 C CE1 . TYR   B 1 369 ? 14.84328  14.86908  -7.30427  1.000 14.58133 ? 351  TYR   B CE1 1 
ATOM   6373 C CE2 . TYR   B 1 369 ? 15.73723  12.83333  -8.22354  1.000 13.34367 ? 351  TYR   B CE2 1 
ATOM   6374 C CZ  . TYR   B 1 369 ? 15.68034  14.21939  -8.19111  1.000 9.31575  ? 351  TYR   B CZ  1 
ATOM   6375 O OH  . TYR   B 1 369 ? 16.45760  14.96269  -9.05238  1.000 11.06272 ? 351  TYR   B OH  1 
ATOM   6376 N N   . ASN   B 1 370 ? 12.05155  12.33440  -2.65836  1.000 11.55366 ? 352  ASN   B N   1 
ATOM   6377 C CA  . ASN   B 1 370 ? 10.96035  12.16511  -1.69655  1.000 14.80069 ? 352  ASN   B CA  1 
ATOM   6378 C C   . ASN   B 1 370 ? 9.64432   12.39440  -2.41980  1.000 15.16129 ? 352  ASN   B C   1 
ATOM   6379 O O   . ASN   B 1 370 ? 9.34284   13.52701  -2.81782  1.000 16.74902 ? 352  ASN   B O   1 
ATOM   6380 C CB  . ASN   B 1 370 ? 11.08366  13.14249  -0.52473  1.000 13.40650 ? 352  ASN   B CB  1 
ATOM   6381 C CG  . ASN   B 1 370 ? 12.23889  12.80915  0.40078   1.000 20.13791 ? 352  ASN   B CG  1 
ATOM   6382 O OD1 . ASN   B 1 370 ? 12.58422  11.64478  0.57979   1.000 18.61148 ? 352  ASN   B OD1 1 
ATOM   6383 N ND2 . ASN   B 1 370 ? 12.82957  13.83516  1.00749   1.000 19.39779 ? 352  ASN   B ND2 1 
ATOM   6384 N N   . TYR   B 1 371 ? 8.84963   11.33390  -2.56244  1.000 13.11608 ? 353  TYR   B N   1 
ATOM   6385 C CA  . TYR   B 1 371 ? 7.58316   11.45057  -3.26976  1.000 16.03481 ? 353  TYR   B CA  1 
ATOM   6386 C C   . TYR   B 1 371 ? 6.67249   12.44821  -2.56568  1.000 18.69993 ? 353  TYR   B C   1 
ATOM   6387 O O   . TYR   B 1 371 ? 6.60985   12.49708  -1.33890  1.000 16.62030 ? 353  TYR   B O   1 
ATOM   6388 C CB  . TYR   B 1 371 ? 6.89677   10.08516  -3.36568  1.000 12.42743 ? 353  TYR   B CB  1 
ATOM   6389 C CG  . TYR   B 1 371 ? 5.47841   10.14127  -3.89006  1.000 14.39992 ? 353  TYR   B CG  1 
ATOM   6390 C CD1 . TYR   B 1 371 ? 5.21794   10.24774  -5.24992  1.000 14.48998 ? 353  TYR   B CD1 1 
ATOM   6391 C CD2 . TYR   B 1 371 ? 4.39451   10.07791  -3.01955  1.000 16.58383 ? 353  TYR   B CD2 1 
ATOM   6392 C CE1 . TYR   B 1 371 ? 3.90421   10.30031  -5.73165  1.000 16.04828 ? 353  TYR   B CE1 1 
ATOM   6393 C CE2 . TYR   B 1 371 ? 3.09049   10.11993  -3.49202  1.000 22.93353 ? 353  TYR   B CE2 1 
ATOM   6394 C CZ  . TYR   B 1 371 ? 2.84700   10.23302  -4.84161  1.000 19.99351 ? 353  TYR   B CZ  1 
ATOM   6395 O OH  . TYR   B 1 371 ? 1.53778   10.27365  -5.28828  1.000 20.37751 ? 353  TYR   B OH  1 
ATOM   6396 N N   . CYS   B 1 372 ? 5.99636   13.27680  -3.34959  1.000 13.41528 ? 354  CYS   B N   1 
ATOM   6397 C CA  . CYS   B 1 372 ? 4.97378   14.16298  -2.81470  1.000 22.99393 ? 354  CYS   B CA  1 
ATOM   6398 C C   . CYS   B 1 372 ? 3.85203   14.25750  -3.84103  1.000 21.18226 ? 354  CYS   B C   1 
ATOM   6399 O O   . CYS   B 1 372 ? 3.98062   13.78857  -4.97636  1.000 17.42912 ? 354  CYS   B O   1 
ATOM   6400 C CB  . CYS   B 1 372 ? 5.55534   15.53815  -2.46754  1.000 18.21484 ? 354  CYS   B CB  1 
ATOM   6401 S SG  . CYS   B 1 372 ? 6.10264   16.43745  -3.91378  1.000 21.25631 ? 354  CYS   B SG  1 
ATOM   6402 N N   . ARG   B 1 373 ? 2.72970   14.86163  -3.44433  1.000 19.14428 ? 355  ARG   B N   1 
ATOM   6403 C CA  . ARG   B 1 373 ? 1.58243   14.82239  -4.34392  1.000 19.35177 ? 355  ARG   B CA  1 
ATOM   6404 C C   . ARG   B 1 373 ? 1.79823   15.62015  -5.62976  1.000 18.73040 ? 355  ARG   B C   1 
ATOM   6405 O O   . ARG   B 1 373 ? 1.09605   15.37159  -6.61225  1.000 21.24935 ? 355  ARG   B O   1 
ATOM   6406 C CB  . ARG   B 1 373 ? 0.31068   15.28429  -3.62630  1.000 26.37551 ? 355  ARG   B CB  1 
ATOM   6407 C CG  . ARG   B 1 373 ? -0.18722  14.30662  -2.55239  1.000 38.63297 ? 355  ARG   B CG  1 
ATOM   6408 C CD  . ARG   B 1 373 ? -1.29294  14.91661  -1.68356  1.000 45.05753 ? 355  ARG   B CD  1 
ATOM   6409 N NE  . ARG   B 1 373 ? -0.79967  15.81144  -0.64407  1.000 48.33020 ? 355  ARG   B NE  1 
ATOM   6410 C CZ  . ARG   B 1 373 ? -0.64147  15.46280  0.62607   1.000 51.78282 ? 355  ARG   B CZ  1 
ATOM   6411 N NH1 . ARG   B 1 373 ? -0.95561  14.25155  1.05346   1.000 48.83669 ? 355  ARG   B NH1 1 
ATOM   6412 N NH2 . ARG   B 1 373 ? -0.15837  16.35224  1.48934   1.000 47.65219 ? 355  ARG   B NH2 1 
ATOM   6413 N N   . GLU   B 1 374 ? 2.76231   16.54663  -5.66481  1.000 15.57566 ? 356  GLU   B N   1 
ATOM   6414 C CA  . GLU   B 1 374 ? 3.04524   17.26305  -6.90533  1.000 17.55597 ? 356  GLU   B CA  1 
ATOM   6415 C C   . GLU   B 1 374 ? 3.75245   16.40829  -7.95312  1.000 23.20508 ? 356  GLU   B C   1 
ATOM   6416 O O   . GLU   B 1 374 ? 3.98463   16.91081  -9.05656  1.000 19.79255 ? 356  GLU   B O   1 
ATOM   6417 C CB  . GLU   B 1 374 ? 3.90931   18.49646  -6.63980  1.000 24.09767 ? 356  GLU   B CB  1 
ATOM   6418 C CG  . GLU   B 1 374 ? 3.16863   19.69410  -6.09078  1.000 37.93614 ? 356  GLU   B CG  1 
ATOM   6419 C CD  . GLU   B 1 374 ? 3.48033   19.92778  -4.62987  1.000 48.59334 ? 356  GLU   B CD  1 
ATOM   6420 O OE1 . GLU   B 1 374 ? 3.79375   18.93576  -3.93134  1.000 49.99251 ? 356  GLU   B OE1 1 
ATOM   6421 O OE2 . GLU   B 1 374 ? 3.42815   21.10070  -4.18760  1.000 44.24794 ? 356  GLU   B OE2 1 
ATOM   6422 N N   . ASP   B 1 375 ? 4.10822   15.15943  -7.63818  1.000 22.26123 ? 357  ASP   B N   1 
ATOM   6423 C CA  . ASP   B 1 375 ? 4.79703   14.25637  -8.55386  1.000 20.83276 ? 357  ASP   B CA  1 
ATOM   6424 C C   . ASP   B 1 375 ? 3.85193   13.49138  -9.46568  1.000 26.03843 ? 357  ASP   B C   1 
ATOM   6425 O O   . ASP   B 1 375 ? 4.23169   12.42670  -9.96818  1.000 24.08315 ? 357  ASP   B O   1 
ATOM   6426 C CB  . ASP   B 1 375 ? 5.65401   13.25737  -7.77017  1.000 19.32286 ? 357  ASP   B CB  1 
ATOM   6427 C CG  . ASP   B 1 375 ? 6.80564   13.91402  -7.05900  1.000 15.92489 ? 357  ASP   B CG  1 
ATOM   6428 O OD1 . ASP   B 1 375 ? 7.30401   14.93672  -7.57559  1.000 22.53947 ? 357  ASP   B OD1 1 
ATOM   6429 O OD2 . ASP   B 1 375 ? 7.21635   13.42046  -5.98222  1.000 22.26994 ? 357  ASP   B OD2 1 
ATOM   6430 N N   . GLU   B 1 376 ? 2.64130   14.01239  -9.69278  1.000 21.57006 ? 358  GLU   B N   1 
ATOM   6431 C CA  . GLU   B 1 376 ? 1.62892   13.30180  -10.47114 1.000 20.62784 ? 358  GLU   B CA  1 
ATOM   6432 C C   . GLU   B 1 376 ? 2.16430   12.80025  -11.80214 1.000 24.59467 ? 358  GLU   B C   1 
ATOM   6433 O O   . GLU   B 1 376 ? 1.82248   11.69595  -12.23298 1.000 17.53980 ? 358  GLU   B O   1 
ATOM   6434 C CB  . GLU   B 1 376 ? 0.42959   14.21323  -10.72533 1.000 21.80887 ? 358  GLU   B CB  1 
ATOM   6435 C CG  . GLU   B 1 376 ? -0.66303  14.09597  -9.71011  1.000 28.34550 ? 358  GLU   B CG  1 
ATOM   6436 C CD  . GLU   B 1 376 ? -1.81768  15.03213  -10.00670 1.000 35.05409 ? 358  GLU   B CD  1 
ATOM   6437 O OE1 . GLU   B 1 376 ? -1.81335  16.15424  -9.46471  1.000 40.82008 ? 358  GLU   B OE1 1 
ATOM   6438 O OE2 . GLU   B 1 376 ? -2.73340  14.64797  -10.75805 1.000 44.21420 ? 358  GLU   B OE2 1 
ATOM   6439 N N   . GLU   B 1 377 ? 2.98408   13.60395  -12.48659 1.000 15.98354 ? 359  GLU   B N   1 
ATOM   6440 C CA  . GLU   B 1 377 ? 3.37248   13.22883  -13.84244 1.000 19.15110 ? 359  GLU   B CA  1 
ATOM   6441 C C   . GLU   B 1 377 ? 4.31727   12.03288  -13.82837 1.000 20.16588 ? 359  GLU   B C   1 
ATOM   6442 O O   . GLU   B 1 377 ? 4.14801   11.08477  -14.60280 1.000 18.98766 ? 359  GLU   B O   1 
ATOM   6443 C CB  . GLU   B 1 377 ? 4.00835   14.41924  -14.56353 1.000 18.66647 ? 359  GLU   B CB  1 
ATOM   6444 C CG  . GLU   B 1 377 ? 4.15629   14.25188  -16.07686 1.000 20.22657 ? 359  GLU   B CG  1 
ATOM   6445 C CD  . GLU   B 1 377 ? 2.83319   14.00894  -16.80886 1.000 29.14400 ? 359  GLU   B CD  1 
ATOM   6446 O OE1 . GLU   B 1 377 ? 1.75250   14.33194  -16.26934 1.000 28.24725 ? 359  GLU   B OE1 1 
ATOM   6447 O OE2 . GLU   B 1 377 ? 2.87685   13.49563  -17.94336 1.000 34.61390 ? 359  GLU   B OE2 1 
ATOM   6448 N N   . ILE   B 1 378 ? 5.32574   12.06012  -12.96055 1.000 16.04170 ? 360  ILE   B N   1 
ATOM   6449 C CA  . ILE   B 1 378 ? 6.26510   10.94648  -12.94789 1.000 16.07106 ? 360  ILE   B CA  1 
ATOM   6450 C C   . ILE   B 1 378 ? 5.68118   9.74082   -12.22270 1.000 15.70908 ? 360  ILE   B C   1 
ATOM   6451 O O   . ILE   B 1 378 ? 6.06452   8.60286   -12.50803 1.000 16.71545 ? 360  ILE   B O   1 
ATOM   6452 C CB  . ILE   B 1 378 ? 7.61141   11.39314  -12.35167 1.000 14.61006 ? 360  ILE   B CB  1 
ATOM   6453 C CG1 . ILE   B 1 378 ? 8.73830   10.51200  -12.89080 1.000 17.19719 ? 360  ILE   B CG1 1 
ATOM   6454 C CG2 . ILE   B 1 378 ? 7.56599   11.40959  -10.83947 1.000 18.44517 ? 360  ILE   B CG2 1 
ATOM   6455 C CD1 . ILE   B 1 378 ? 9.00572   10.71536  -14.38579 1.000 18.26518 ? 360  ILE   B CD1 1 
ATOM   6456 N N   . TYR   B 1 379 ? 4.73463   9.94635   -11.29852 1.000 13.94641 ? 361  TYR   B N   1 
ATOM   6457 C CA  . TYR   B 1 379 ? 4.00594   8.79940   -10.76635 1.000 15.95452 ? 361  TYR   B CA  1 
ATOM   6458 C C   . TYR   B 1 379 ? 3.29118   8.05472   -11.88805 1.000 16.40234 ? 361  TYR   B C   1 
ATOM   6459 O O   . TYR   B 1 379 ? 3.32514   6.82112   -11.94216 1.000 14.71383 ? 361  TYR   B O   1 
ATOM   6460 C CB  . TYR   B 1 379 ? 3.01462   9.23523   -9.67504  1.000 15.96105 ? 361  TYR   B CB  1 
ATOM   6461 C CG  . TYR   B 1 379 ? 2.09679   8.10609   -9.19258  1.000 13.85544 ? 361  TYR   B CG  1 
ATOM   6462 C CD1 . TYR   B 1 379 ? 0.94869   7.75670   -9.90162  1.000 16.55601 ? 361  TYR   B CD1 1 
ATOM   6463 C CD2 . TYR   B 1 379 ? 2.40078   7.38695   -8.04472  1.000 13.42439 ? 361  TYR   B CD2 1 
ATOM   6464 C CE1 . TYR   B 1 379 ? 0.12805   6.72476   -9.47982  1.000 14.50624 ? 361  TYR   B CE1 1 
ATOM   6465 C CE2 . TYR   B 1 379 ? 1.58138   6.36011   -7.60405  1.000 17.35631 ? 361  TYR   B CE2 1 
ATOM   6466 C CZ  . TYR   B 1 379 ? 0.44979   6.03518   -8.33034  1.000 16.99084 ? 361  TYR   B CZ  1 
ATOM   6467 O OH  . TYR   B 1 379 ? -0.35915  5.01538   -7.91355  1.000 16.36726 ? 361  TYR   B OH  1 
ATOM   6468 N N   A LYS   B 1 380 ? 2.64415   8.78254   -12.80311 0.527 15.34098 ? 362  LYS   B N   1 
ATOM   6469 N N   B LYS   B 1 380 ? 2.65202   8.79439   -12.79903 0.473 15.35483 ? 362  LYS   B N   1 
ATOM   6470 C CA  A LYS   B 1 380 ? 1.93732   8.11379   -13.89346 0.527 17.82554 ? 362  LYS   B CA  1 
ATOM   6471 C CA  B LYS   B 1 380 ? 1.94107   8.16872   -13.90982 0.473 17.85508 ? 362  LYS   B CA  1 
ATOM   6472 C C   A LYS   B 1 380 ? 2.89911   7.32704   -14.77645 0.527 18.40215 ? 362  LYS   B C   1 
ATOM   6473 C C   B LYS   B 1 380 ? 2.88551   7.35436   -14.78554 0.473 18.39529 ? 362  LYS   B C   1 
ATOM   6474 O O   A LYS   B 1 380 ? 2.58777   6.20507   -15.19450 0.527 15.73682 ? 362  LYS   B O   1 
ATOM   6475 O O   B LYS   B 1 380 ? 2.54609   6.24271   -15.21007 0.473 15.73463 ? 362  LYS   B O   1 
ATOM   6476 C CB  A LYS   B 1 380 ? 1.15429   9.12885   -14.72994 0.527 18.59384 ? 362  LYS   B CB  1 
ATOM   6477 C CB  B LYS   B 1 380 ? 1.23181   9.23950   -14.74261 0.473 18.54691 ? 362  LYS   B CB  1 
ATOM   6478 C CG  A LYS   B 1 380 ? 0.17167   8.50517   -15.72584 0.527 22.56618 ? 362  LYS   B CG  1 
ATOM   6479 C CG  B LYS   B 1 380 ? 0.24025   8.69319   -15.75336 0.473 22.26552 ? 362  LYS   B CG  1 
ATOM   6480 C CD  A LYS   B 1 380 ? -0.42311  7.17852   -15.22130 0.527 31.07925 ? 362  LYS   B CD  1 
ATOM   6481 C CD  B LYS   B 1 380 ? -0.51740  7.49335   -15.19312 0.473 31.31845 ? 362  LYS   B CD  1 
ATOM   6482 C CE  A LYS   B 1 380 ? -0.27187  6.05094   -16.25145 0.527 25.60422 ? 362  LYS   B CE  1 
ATOM   6483 C CE  B LYS   B 1 380 ? -0.40460  6.27760   -16.10481 0.473 25.91109 ? 362  LYS   B CE  1 
ATOM   6484 N NZ  A LYS   B 1 380 ? -1.52686  5.25330   -16.44517 0.527 24.35369 ? 362  LYS   B NZ  1 
ATOM   6485 N NZ  B LYS   B 1 380 ? -0.06888  5.05270   -15.33149 0.473 19.45265 ? 362  LYS   B NZ  1 
ATOM   6486 N N   . GLU   B 1 381 ? 4.07845   7.89065   -15.06035 1.000 16.26035 ? 363  GLU   B N   1 
ATOM   6487 C CA  . GLU   B 1 381 ? 5.03841   7.18449   -15.90787 1.000 23.38434 ? 363  GLU   B CA  1 
ATOM   6488 C C   . GLU   B 1 381 ? 5.58413   5.94032   -15.21724 1.000 13.01239 ? 363  GLU   B C   1 
ATOM   6489 O O   . GLU   B 1 381 ? 5.75010   4.89692   -15.85721 1.000 14.24377 ? 363  GLU   B O   1 
ATOM   6490 C CB  . GLU   B 1 381 ? 6.18721   8.11242   -16.31290 1.000 18.21041 ? 363  GLU   B CB  1 
ATOM   6491 C CG  . GLU   B 1 381 ? 5.75064   9.33301   -17.11009 1.000 28.75426 ? 363  GLU   B CG  1 
ATOM   6492 C CD  . GLU   B 1 381 ? 5.57811   9.04667   -18.59854 1.000 32.80169 ? 363  GLU   B CD  1 
ATOM   6493 O OE1 . GLU   B 1 381 ? 5.62889   7.86272   -19.01515 1.000 27.53116 ? 363  GLU   B OE1 1 
ATOM   6494 O OE2 . GLU   B 1 381 ? 5.39171   10.02099  -19.35664 1.000 35.81143 ? 363  GLU   B OE2 1 
ATOM   6495 N N   . PHE   B 1 382 ? 5.87423   6.03024   -13.91784 1.000 13.40609 ? 364  PHE   B N   1 
ATOM   6496 C CA  . PHE   B 1 382 ? 6.31593   4.84476   -13.18758 1.000 11.60310 ? 364  PHE   B CA  1 
ATOM   6497 C C   . PHE   B 1 382 ? 5.19046   3.81985   -13.08568 1.000 14.43717 ? 364  PHE   B C   1 
ATOM   6498 O O   . PHE   B 1 382 ? 5.42255   2.61393   -13.22605 1.000 9.32840  ? 364  PHE   B O   1 
ATOM   6499 C CB  . PHE   B 1 382 ? 6.82513   5.23763   -11.79439 1.000 12.30471 ? 364  PHE   B CB  1 
ATOM   6500 C CG  . PHE   B 1 382 ? 8.26718   5.68778   -11.76731 1.000 16.71216 ? 364  PHE   B CG  1 
ATOM   6501 C CD1 . PHE   B 1 382 ? 9.29220   4.83853   -12.17378 1.000 16.36856 ? 364  PHE   B CD1 1 
ATOM   6502 C CD2 . PHE   B 1 382 ? 8.59895   6.96132   -11.32285 1.000 15.08659 ? 364  PHE   B CD2 1 
ATOM   6503 C CE1 . PHE   B 1 382 ? 10.62750  5.25364   -12.14568 1.000 18.21866 ? 364  PHE   B CE1 1 
ATOM   6504 C CE2 . PHE   B 1 382 ? 9.93244   7.39084   -11.29538 1.000 18.05414 ? 364  PHE   B CE2 1 
ATOM   6505 C CZ  . PHE   B 1 382 ? 10.94998  6.52763   -11.71057 1.000 17.97854 ? 364  PHE   B CZ  1 
ATOM   6506 N N   . PHE   B 1 383 ? 3.95682   4.28145   -12.87907 1.000 13.07758 ? 365  PHE   B N   1 
ATOM   6507 C CA  . PHE   B 1 383 ? 2.82874   3.35748   -12.82496 1.000 14.04772 ? 365  PHE   B CA  1 
ATOM   6508 C C   . PHE   B 1 383 ? 2.67748   2.59662   -14.13760 1.000 14.41096 ? 365  PHE   B C   1 
ATOM   6509 O O   . PHE   B 1 383 ? 2.47086   1.37606   -14.14228 1.000 15.60877 ? 365  PHE   B O   1 
ATOM   6510 C CB  . PHE   B 1 383 ? 1.54341   4.11645   -12.48703 1.000 15.71106 ? 365  PHE   B CB  1 
ATOM   6511 C CG  . PHE   B 1 383 ? 0.37917   3.22122   -12.17404 1.000 15.87108 ? 365  PHE   B CG  1 
ATOM   6512 C CD1 . PHE   B 1 383 ? -0.32621  2.59182   -13.19113 1.000 14.21169 ? 365  PHE   B CD1 1 
ATOM   6513 C CD2 . PHE   B 1 383 ? -0.00189  3.00053   -10.86268 1.000 17.68752 ? 365  PHE   B CD2 1 
ATOM   6514 C CE1 . PHE   B 1 383 ? -1.39036  1.74813   -12.90544 1.000 17.96371 ? 365  PHE   B CE1 1 
ATOM   6515 C CE2 . PHE   B 1 383 ? -1.06866  2.17006   -10.56812 1.000 17.04273 ? 365  PHE   B CE2 1 
ATOM   6516 C CZ  . PHE   B 1 383 ? -1.76226  1.54220   -11.59690 1.000 21.25961 ? 365  PHE   B CZ  1 
ATOM   6517 N N   . GLU   B 1 384 ? 2.75271   3.31251   -15.26392 1.000 13.13689 ? 366  GLU   B N   1 
ATOM   6518 C CA  . GLU   B 1 384 ? 2.59462   2.68266   -16.56770 1.000 14.36907 ? 366  GLU   B CA  1 
ATOM   6519 C C   . GLU   B 1 384 ? 3.69319   1.66252   -16.84263 1.000 16.18842 ? 366  GLU   B C   1 
ATOM   6520 O O   . GLU   B 1 384 ? 3.42413   0.60845   -17.42340 1.000 15.77499 ? 366  GLU   B O   1 
ATOM   6521 C CB  . GLU   B 1 384 ? 2.56441   3.74653   -17.66327 1.000 15.89554 ? 366  GLU   B CB  1 
ATOM   6522 C CG  . GLU   B 1 384 ? 2.15731   3.20235   -19.01948 1.000 29.05519 ? 366  GLU   B CG  1 
ATOM   6523 C CD  . GLU   B 1 384 ? 1.99886   4.29025   -20.06403 1.000 44.64115 ? 366  GLU   B CD  1 
ATOM   6524 O OE1 . GLU   B 1 384 ? 1.78189   5.46307   -19.67930 1.000 33.65046 ? 366  GLU   B OE1 1 
ATOM   6525 O OE2 . GLU   B 1 384 ? 2.09617   3.96993   -21.26766 1.000 46.87147 ? 366  GLU   B OE2 1 
ATOM   6526 N N   . VAL   B 1 385 ? 4.93439   1.95432   -16.43766 1.000 12.71571 ? 367  VAL   B N   1 
ATOM   6527 C CA  . VAL   B 1 385 ? 6.02834   1.00465   -16.65427 1.000 10.01517 ? 367  VAL   B CA  1 
ATOM   6528 C C   . VAL   B 1 385 ? 5.83234   -0.23843  -15.79535 1.000 14.82439 ? 367  VAL   B C   1 
ATOM   6529 O O   . VAL   B 1 385 ? 5.93632   -1.37122  -16.27934 1.000 14.65589 ? 367  VAL   B O   1 
ATOM   6530 C CB  . VAL   B 1 385 ? 7.38956   1.66861   -16.36660 1.000 15.73799 ? 367  VAL   B CB  1 
ATOM   6531 C CG1 . VAL   B 1 385 ? 8.51946   0.61624   -16.35321 1.000 10.17583 ? 367  VAL   B CG1 1 
ATOM   6532 C CG2 . VAL   B 1 385 ? 7.67951   2.76301   -17.38655 1.000 14.34419 ? 367  VAL   B CG2 1 
ATOM   6533 N N   . ALA   B 1 386 ? 5.54564   -0.04806  -14.50665 1.000 13.13077 ? 368  ALA   B N   1 
ATOM   6534 C CA  . ALA   B 1 386 ? 5.43067   -1.19171  -13.60203 1.000 13.95423 ? 368  ALA   B CA  1 
ATOM   6535 C C   . ALA   B 1 386 ? 4.20089   -2.04297  -13.90073 1.000 14.46639 ? 368  ALA   B C   1 
ATOM   6536 O O   . ALA   B 1 386 ? 4.25238   -3.27380  -13.79321 1.000 13.28144 ? 368  ALA   B O   1 
ATOM   6537 C CB  . ALA   B 1 386 ? 5.38666   -0.70808  -12.15358 1.000 14.01623 ? 368  ALA   B CB  1 
ATOM   6538 N N   . ASN   B 1 387 ? 3.08158   -1.41611  -14.25341 1.000 11.86367 ? 369  ASN   B N   1 
ATOM   6539 C CA  . ASN   B 1 387 ? 1.80659   -2.12251  -14.29563 1.000 14.72456 ? 369  ASN   B CA  1 
ATOM   6540 C C   . ASN   B 1 387 ? 1.25514   -2.29995  -15.70408 1.000 18.13694 ? 369  ASN   B C   1 
ATOM   6541 O O   . ASN   B 1 387 ? 0.11622   -2.75174  -15.85921 1.000 15.93303 ? 369  ASN   B O   1 
ATOM   6542 C CB  . ASN   B 1 387 ? 0.80225   -1.40217  -13.39664 1.000 14.11773 ? 369  ASN   B CB  1 
ATOM   6543 C CG  . ASN   B 1 387 ? 1.32140   -1.25649  -11.99364 1.000 16.34726 ? 369  ASN   B CG  1 
ATOM   6544 O OD1 . ASN   B 1 387 ? 1.77959   -2.23332  -11.39842 1.000 17.41200 ? 369  ASN   B OD1 1 
ATOM   6545 N ND2 . ASN   B 1 387 ? 1.29839   -0.04254  -11.46449 1.000 14.22658 ? 369  ASN   B ND2 1 
ATOM   6546 N N   . ASP   B 1 388 ? 2.04407   -2.00253  -16.73236 1.000 13.86298 ? 370  ASP   B N   1 
ATOM   6547 C CA  . ASP   B 1 388 ? 1.59358   -2.23523  -18.09703 1.000 16.56314 ? 370  ASP   B CA  1 
ATOM   6548 C C   . ASP   B 1 388 ? 2.75890   -2.60075  -19.00778 1.000 14.77845 ? 370  ASP   B C   1 
ATOM   6549 O O   . ASP   B 1 388 ? 2.75870   -3.67929  -19.61119 1.000 20.17654 ? 370  ASP   B O   1 
ATOM   6550 C CB  . ASP   B 1 388 ? 0.85261   -1.00618  -18.63763 1.000 19.33334 ? 370  ASP   B CB  1 
ATOM   6551 C CG  . ASP   B 1 388 ? 0.26995   -1.23986  -20.02107 1.000 33.70140 ? 370  ASP   B CG  1 
ATOM   6552 O OD1 . ASP   B 1 388 ? -0.30678  -2.32329  -20.25135 1.000 30.09137 ? 370  ASP   B OD1 1 
ATOM   6553 O OD2 . ASP   B 1 388 ? 0.37146   -0.33534  -20.87166 1.000 35.78042 ? 370  ASP   B OD2 1 
ATOM   6554 N N   . VAL   B 1 389 ? 3.75943   -1.72156  -19.10878 1.000 11.50022 ? 371  VAL   B N   1 
ATOM   6555 C CA  . VAL   B 1 389 ? 4.81991   -1.92220  -20.09456 1.000 16.21916 ? 371  VAL   B CA  1 
ATOM   6556 C C   . VAL   B 1 389 ? 5.67273   -3.14158  -19.73883 1.000 16.27055 ? 371  VAL   B C   1 
ATOM   6557 O O   . VAL   B 1 389 ? 5.86105   -4.04437  -20.56383 1.000 17.44496 ? 371  VAL   B O   1 
ATOM   6558 C CB  . VAL   B 1 389 ? 5.66872   -0.64481  -20.23505 1.000 20.50167 ? 371  VAL   B CB  1 
ATOM   6559 C CG1 . VAL   B 1 389 ? 6.73878   -0.84749  -21.26990 1.000 17.81571 ? 371  VAL   B CG1 1 
ATOM   6560 C CG2 . VAL   B 1 389 ? 4.78012   0.55069   -20.63657 1.000 17.68785 ? 371  VAL   B CG2 1 
ATOM   6561 N N   . ILE   B 1 390 ? 6.19704   -3.19851  -18.50829 1.000 14.51964 ? 372  ILE   B N   1 
ATOM   6562 C CA  . ILE   B 1 390 ? 6.99228   -4.36650  -18.10308 1.000 14.93332 ? 372  ILE   B CA  1 
ATOM   6563 C C   . ILE   B 1 390 ? 6.16274   -5.64854  -18.11988 1.000 11.78701 ? 372  ILE   B C   1 
ATOM   6564 O O   . ILE   B 1 390 ? 6.66046   -6.67447  -18.61660 1.000 16.56023 ? 372  ILE   B O   1 
ATOM   6565 C CB  . ILE   B 1 390 ? 7.66817   -4.10644  -16.74460 1.000 15.06868 ? 372  ILE   B CB  1 
ATOM   6566 C CG1 . ILE   B 1 390 ? 8.81392   -3.10376  -16.89743 1.000 11.10707 ? 372  ILE   B CG1 1 
ATOM   6567 C CG2 . ILE   B 1 390 ? 8.15668   -5.42486  -16.11049 1.000 12.83100 ? 372  ILE   B CG2 1 
ATOM   6568 C CD1 . ILE   B 1 390 ? 9.50767   -2.75320  -15.57280 1.000 12.71216 ? 372  ILE   B CD1 1 
ATOM   6569 N N   . PRO   B 1 391 ? 4.92894   -5.68051  -17.60325 1.000 16.74937 ? 373  PRO   B N   1 
ATOM   6570 C CA  . PRO   B 1 391 ? 4.12253   -6.90290  -17.76573 1.000 16.86253 ? 373  PRO   B CA  1 
ATOM   6571 C C   . PRO   B 1 391 ? 4.02842   -7.37731  -19.20442 1.000 20.12521 ? 373  PRO   B C   1 
ATOM   6572 O O   . PRO   B 1 391 ? 4.25210   -8.56517  -19.47533 1.000 20.25128 ? 373  PRO   B O   1 
ATOM   6573 C CB  . PRO   B 1 391 ? 2.76645   -6.48478  -17.19196 1.000 18.02222 ? 373  PRO   B CB  1 
ATOM   6574 C CG  . PRO   B 1 391 ? 3.14862   -5.56840  -16.08696 1.000 15.84040 ? 373  PRO   B CG  1 
ATOM   6575 C CD  . PRO   B 1 391 ? 4.29194   -4.75346  -16.65132 1.000 18.29087 ? 373  PRO   B CD  1 
ATOM   6576 N N   . ASN   B 1 392 ? 3.72091   -6.47972  -20.14247 1.000 19.90033 ? 374  ASN   B N   1 
ATOM   6577 C CA  . ASN   B 1 392 ? 3.61485   -6.88853  -21.54315 1.000 19.32807 ? 374  ASN   B CA  1 
ATOM   6578 C C   . ASN   B 1 392 ? 4.94357   -7.40149  -22.07797 1.000 19.61354 ? 374  ASN   B C   1 
ATOM   6579 O O   . ASN   B 1 392 ? 4.98234   -8.41052  -22.79501 1.000 24.27149 ? 374  ASN   B O   1 
ATOM   6580 C CB  . ASN   B 1 392 ? 3.11129   -5.72523  -22.39768 1.000 24.17480 ? 374  ASN   B CB  1 
ATOM   6581 C CG  . ASN   B 1 392 ? 1.66008   -5.39941  -22.12536 1.000 32.25130 ? 374  ASN   B CG  1 
ATOM   6582 O OD1 . ASN   B 1 392 ? 0.89104   -6.26803  -21.70770 1.000 42.29338 ? 374  ASN   B OD1 1 
ATOM   6583 N ND2 . ASN   B 1 392 ? 1.27604   -4.14264  -22.34413 1.000 37.36605 ? 374  ASN   B ND2 1 
ATOM   6584 N N   . LEU   B 1 393 ? 6.03919   -6.70989  -21.74785 1.000 18.33095 ? 375  LEU   B N   1 
ATOM   6585 C CA  . LEU   B 1 393 ? 7.36786   -7.12720  -22.18487 1.000 14.99429 ? 375  LEU   B CA  1 
ATOM   6586 C C   . LEU   B 1 393 ? 7.70586   -8.52773  -21.68945 1.000 16.24515 ? 375  LEU   B C   1 
ATOM   6587 O O   . LEU   B 1 393 ? 8.22064   -9.35567  -22.45126 1.000 19.85020 ? 375  LEU   B O   1 
ATOM   6588 C CB  . LEU   B 1 393 ? 8.41300   -6.12674  -21.68626 1.000 14.69748 ? 375  LEU   B CB  1 
ATOM   6589 C CG  . LEU   B 1 393 ? 8.79357   -4.98502  -22.61646 1.000 25.67779 ? 375  LEU   B CG  1 
ATOM   6590 C CD1 . LEU   B 1 393 ? 9.85704   -4.09716  -21.95986 1.000 24.29066 ? 375  LEU   B CD1 1 
ATOM   6591 C CD2 . LEU   B 1 393 ? 9.29989   -5.54270  -23.92903 1.000 23.65236 ? 375  LEU   B CD2 1 
ATOM   6592 N N   . LEU   B 1 394 ? 7.45968   -8.80157  -20.40149 1.000 16.09885 ? 376  LEU   B N   1 
ATOM   6593 C CA  . LEU   B 1 394 ? 7.78786   -10.11523 -19.85328 1.000 15.80191 ? 376  LEU   B CA  1 
ATOM   6594 C C   . LEU   B 1 394 ? 6.82186   -11.18283 -20.35312 1.000 22.80424 ? 376  LEU   B C   1 
ATOM   6595 O O   . LEU   B 1 394 ? 7.22620   -12.32583 -20.59426 1.000 21.27139 ? 376  LEU   B O   1 
ATOM   6596 C CB  . LEU   B 1 394 ? 7.78741   -10.08317 -18.32035 1.000 14.47088 ? 376  LEU   B CB  1 
ATOM   6597 C CG  . LEU   B 1 394 ? 8.73040   -9.09029  -17.63161 1.000 15.87468 ? 376  LEU   B CG  1 
ATOM   6598 C CD1 . LEU   B 1 394 ? 8.47338   -9.06623  -16.14015 1.000 14.62842 ? 376  LEU   B CD1 1 
ATOM   6599 C CD2 . LEU   B 1 394 ? 10.20220  -9.42272  -17.93325 1.000 15.94068 ? 376  LEU   B CD2 1 
ATOM   6600 N N   . LYS   B 1 395 ? 5.53903   -10.83478 -20.48714 1.000 16.65997 ? 377  LYS   B N   1 
ATOM   6601 C CA  . LYS   B 1 395 ? 4.55117   -11.79095 -20.97909 1.000 21.33411 ? 377  LYS   B CA  1 
ATOM   6602 C C   . LYS   B 1 395 ? 4.94374   -12.31578 -22.35192 1.000 25.04431 ? 377  LYS   B C   1 
ATOM   6603 O O   . LYS   B 1 395 ? 4.88157   -13.52461 -22.61677 1.000 26.17749 ? 377  LYS   B O   1 
ATOM   6604 C CB  . LYS   B 1 395 ? 3.17122   -11.12996 -21.03866 1.000 18.78251 ? 377  LYS   B CB  1 
ATOM   6605 C CG  . LYS   B 1 395 ? 2.13981   -11.92887 -21.82769 1.000 24.26268 ? 377  LYS   B CG  1 
ATOM   6606 C CD  . LYS   B 1 395 ? 0.74366   -11.66447 -21.30644 1.000 23.65368 ? 377  LYS   B CD  1 
ATOM   6607 C CE  . LYS   B 1 395 ? -0.31902  -12.25924 -22.21936 1.000 34.57213 ? 377  LYS   B CE  1 
ATOM   6608 N NZ  . LYS   B 1 395 ? -1.65608  -11.70699 -21.88616 1.000 33.99145 ? 377  LYS   B NZ  1 
ATOM   6609 N N   . GLU   B 1 396 ? 5.35104   -11.41284 -23.24340 1.000 19.26478 ? 378  GLU   B N   1 
ATOM   6610 C CA  . GLU   B 1 396 ? 5.76333   -11.83070 -24.57625 1.000 23.84427 ? 378  GLU   B CA  1 
ATOM   6611 C C   . GLU   B 1 396 ? 7.07539   -12.60046 -24.52395 1.000 28.18184 ? 378  GLU   B C   1 
ATOM   6612 O O   . GLU   B 1 396 ? 7.23216   -13.62186 -25.20649 1.000 25.27353 ? 378  GLU   B O   1 
ATOM   6613 C CB  . GLU   B 1 396 ? 5.88585   -10.60577 -25.48468 1.000 29.00793 ? 378  GLU   B CB  1 
ATOM   6614 C CG  . GLU   B 1 396 ? 6.19588   -10.92383 -26.93554 1.000 29.25654 ? 378  GLU   B CG  1 
ATOM   6615 C CD  . GLU   B 1 396 ? 6.63789   -9.69787  -27.71770 1.000 38.57426 ? 378  GLU   B CD  1 
ATOM   6616 O OE1 . GLU   B 1 396 ? 7.16428   -8.74856  -27.09456 1.000 38.98458 ? 378  GLU   B OE1 1 
ATOM   6617 O OE2 . GLU   B 1 396 ? 6.44928   -9.68124  -28.95305 1.000 41.74013 ? 378  GLU   B OE2 1 
ATOM   6618 N N   . ALA   B 1 397 ? 8.02930   -12.12864 -23.71276 1.000 22.55417 ? 379  ALA   B N   1 
ATOM   6619 C CA  . ALA   B 1 397 ? 9.28327   -12.85719 -23.54922 1.000 25.00622 ? 379  ALA   B CA  1 
ATOM   6620 C C   . ALA   B 1 397 ? 9.02705   -14.27662 -23.06411 1.000 18.15265 ? 379  ALA   B C   1 
ATOM   6621 O O   . ALA   B 1 397 ? 9.72373   -15.21778 -23.46742 1.000 21.24711 ? 379  ALA   B O   1 
ATOM   6622 C CB  . ALA   B 1 397 ? 10.19845  -12.10945 -22.57672 1.000 20.80563 ? 379  ALA   B CB  1 
ATOM   6623 N N   . ALA   B 1 398 ? 8.01606   -14.44776 -22.20716 1.000 21.29550 ? 380  ALA   B N   1 
ATOM   6624 C CA  . ALA   B 1 398 ? 7.67018   -15.76596 -21.68430 1.000 23.88869 ? 380  ALA   B CA  1 
ATOM   6625 C C   . ALA   B 1 398 ? 7.10492   -16.66680 -22.76994 1.000 28.87016 ? 380  ALA   B C   1 
ATOM   6626 O O   . ALA   B 1 398 ? 7.47428   -17.84535 -22.86006 1.000 25.65689 ? 380  ALA   B O   1 
ATOM   6627 C CB  . ALA   B 1 398 ? 6.66986   -15.62767 -20.53822 1.000 19.50463 ? 380  ALA   B CB  1 
ATOM   6628 N N   A SER   B 1 399 ? 6.19931   -16.13763 -23.59528 0.418 26.21943 ? 381  SER   B N   1 
ATOM   6629 N N   B SER   B 1 399 ? 6.20356   -16.13562 -23.59845 0.582 26.19741 ? 381  SER   B N   1 
ATOM   6630 C CA  A SER   B 1 399 ? 5.67125   -16.92230 -24.70525 0.418 30.50234 ? 381  SER   B CA  1 
ATOM   6631 C CA  B SER   B 1 399 ? 5.67191   -16.92444 -24.70341 0.582 30.54197 ? 381  SER   B CA  1 
ATOM   6632 C C   A SER   B 1 399 ? 6.77808   -17.30688 -25.67641 0.418 31.64193 ? 381  SER   B C   1 
ATOM   6633 C C   B SER   B 1 399 ? 6.77808   -17.30818 -25.67549 0.582 31.69499 ? 381  SER   B C   1 
ATOM   6634 O O   A SER   B 1 399 ? 6.83451   -18.45123 -26.14089 0.418 28.35613 ? 381  SER   B O   1 
ATOM   6635 O O   B SER   B 1 399 ? 6.83705   -18.45378 -26.13669 0.582 28.32060 ? 381  SER   B O   1 
ATOM   6636 C CB  A SER   B 1 399 ? 4.56945   -16.14343 -25.42531 0.418 30.59726 ? 381  SER   B CB  1 
ATOM   6637 C CB  B SER   B 1 399 ? 4.56566   -16.14888 -25.42296 0.582 30.61966 ? 381  SER   B CB  1 
ATOM   6638 O OG  A SER   B 1 399 ? 3.80653   -15.37098 -24.51286 0.418 26.61656 ? 381  SER   B OG  1 
ATOM   6639 O OG  B SER   B 1 399 ? 3.68000   -17.02501 -26.10332 0.582 31.79140 ? 381  SER   B OG  1 
ATOM   6640 N N   . LEU   B 1 400 ? 7.67990   -16.36847 -25.97967 1.000 25.64755 ? 382  LEU   B N   1 
ATOM   6641 C CA  . LEU   B 1 400 ? 8.76736   -16.65763 -26.91492 1.000 29.58743 ? 382  LEU   B CA  1 
ATOM   6642 C C   . LEU   B 1 400 ? 9.71883   -17.71036 -26.35818 1.000 31.22011 ? 382  LEU   B C   1 
ATOM   6643 O O   . LEU   B 1 400 ? 10.19929  -18.58143 -27.09663 1.000 31.38031 ? 382  LEU   B O   1 
ATOM   6644 C CB  . LEU   B 1 400 ? 9.53811   -15.37963 -27.23804 1.000 22.44460 ? 382  LEU   B CB  1 
ATOM   6645 C CG  . LEU   B 1 400 ? 8.78746   -14.25618 -27.95670 1.000 27.58793 ? 382  LEU   B CG  1 
ATOM   6646 C CD1 . LEU   B 1 400 ? 9.56103   -12.94803 -27.81871 1.000 32.60732 ? 382  LEU   B CD1 1 
ATOM   6647 C CD2 . LEU   B 1 400 ? 8.54430   -14.58618 -29.42859 1.000 26.42650 ? 382  LEU   B CD2 1 
ATOM   6648 N N   . LEU   B 1 401 ? 10.00947  -17.64099 -25.06062 1.000 19.48343 ? 383  LEU   B N   1 
ATOM   6649 C CA  . LEU   B 1 401 ? 10.91926  -18.60290 -24.45367 1.000 22.99638 ? 383  LEU   B CA  1 
ATOM   6650 C C   . LEU   B 1 401 ? 10.34708  -20.01538 -24.52964 1.000 30.35190 ? 383  LEU   B C   1 
ATOM   6651 O O   . LEU   B 1 401 ? 10.98861  -20.93183 -25.05545 1.000 29.04343 ? 383  LEU   B O   1 
ATOM   6652 C CB  . LEU   B 1 401 ? 11.20246  -18.20922 -23.00580 1.000 22.80287 ? 383  LEU   B CB  1 
ATOM   6653 C CG  . LEU   B 1 401 ? 12.01466  -19.18777 -22.15888 1.000 30.80579 ? 383  LEU   B CG  1 
ATOM   6654 C CD1 . LEU   B 1 401 ? 13.34152  -19.48275 -22.84884 1.000 35.33628 ? 383  LEU   B CD1 1 
ATOM   6655 C CD2 . LEU   B 1 401 ? 12.25691  -18.60171 -20.77608 1.000 32.83246 ? 383  LEU   B CD2 1 
ATOM   6656 N N   . GLU   B 1 402 ? 9.13350   -20.21414 -24.00538 1.000 32.87417 ? 384  GLU   B N   1 
ATOM   6657 C CA  . GLU   B 1 402 ? 8.55292   -21.55713 -24.00747 1.000 37.02463 ? 384  GLU   B CA  1 
ATOM   6658 C C   . GLU   B 1 402 ? 8.25609   -22.04693 -25.41832 1.000 35.09997 ? 384  GLU   B C   1 
ATOM   6659 O O   . GLU   B 1 402 ? 8.56062   -23.19684 -25.75514 1.000 37.27919 ? 384  GLU   B O   1 
ATOM   6660 C CB  . GLU   B 1 402 ? 7.28567   -21.62222 -23.15424 1.000 36.43407 ? 384  GLU   B CB  1 
ATOM   6661 C CG  . GLU   B 1 402 ? 7.41631   -21.18698 -21.71588 1.000 37.12925 ? 384  GLU   B CG  1 
ATOM   6662 C CD  . GLU   B 1 402 ? 6.35627   -21.85557 -20.83742 1.000 45.51554 ? 384  GLU   B CD  1 
ATOM   6663 O OE1 . GLU   B 1 402 ? 5.15829   -21.82577 -21.21228 1.000 27.84072 ? 384  GLU   B OE1 1 
ATOM   6664 O OE2 . GLU   B 1 402 ? 6.72457   -22.43161 -19.78750 1.000 29.66780 ? 384  GLU   B OE2 1 
ATOM   6665 N N   . ALA   B 1 403 ? 7.63298   -21.20963 -26.25332 1.000 31.56550 ? 385  ALA   B N   1 
ATOM   6666 C CA  . ALA   B 1 403 ? 7.36545   -21.65152 -27.62046 1.000 39.18257 ? 385  ALA   B CA  1 
ATOM   6667 C C   . ALA   B 1 403 ? 8.65749   -21.98674 -28.35220 1.000 37.54292 ? 385  ALA   B C   1 
ATOM   6668 O O   . ALA   B 1 403 ? 8.66822   -22.86123 -29.22657 1.000 44.85513 ? 385  ALA   B O   1 
ATOM   6669 C CB  . ALA   B 1 403 ? 6.57371   -20.59426 -28.39419 1.000 39.34758 ? 385  ALA   B CB  1 
ATOM   6670 N N   . GLY   B 1 404 ? 9.75395   -21.31352 -28.00292 1.000 32.92145 ? 386  GLY   B N   1 
ATOM   6671 C CA  . GLY   B 1 404 ? 11.04137  -21.67571 -28.57010 1.000 40.34570 ? 386  GLY   B CA  1 
ATOM   6672 C C   . GLY   B 1 404 ? 11.53803  -23.01143 -28.05438 1.000 41.41864 ? 386  GLY   B C   1 
ATOM   6673 O O   . GLY   B 1 404 ? 12.07221  -23.82182 -28.81794 1.000 52.57179 ? 386  GLY   B O   1 
ATOM   6674 N N   . GLU   B 1 405 ? 11.36712  -23.26065 -26.75049 1.000 42.72185 ? 387  GLU   B N   1 
ATOM   6675 C CA  . GLU   B 1 405 ? 11.67806  -24.56667 -26.17896 1.000 40.93582 ? 387  GLU   B CA  1 
ATOM   6676 C C   . GLU   B 1 405 ? 10.93070  -25.68866 -26.88476 1.000 51.66733 ? 387  GLU   B C   1 
ATOM   6677 O O   . GLU   B 1 405 ? 11.37966  -26.83911 -26.84268 1.000 42.16443 ? 387  GLU   B O   1 
ATOM   6678 C CB  . GLU   B 1 405 ? 11.32602  -24.60017 -24.68882 1.000 46.07084 ? 387  GLU   B CB  1 
ATOM   6679 C CG  . GLU   B 1 405 ? 12.12711  -23.66199 -23.79415 1.000 41.84954 ? 387  GLU   B CG  1 
ATOM   6680 C CD  . GLU   B 1 405 ? 11.62898  -23.68227 -22.35364 1.000 56.52092 ? 387  GLU   B CD  1 
ATOM   6681 O OE1 . GLU   B 1 405 ? 11.47116  -24.78595 -21.78571 1.000 68.41091 ? 387  GLU   B OE1 1 
ATOM   6682 O OE2 . GLU   B 1 405 ? 11.37204  -22.59674 -21.79298 1.000 45.54809 ? 387  GLU   B OE2 1 
ATOM   6683 N N   . GLU   B 1 406 ? 9.80253   -25.37629 -27.51950 1.000 44.54527 ? 388  GLU   B N   1 
ATOM   6684 C CA  . GLU   B 1 406 ? 8.97387   -26.35535 -28.21601 1.000 42.84135 ? 388  GLU   B CA  1 
ATOM   6685 C C   . GLU   B 1 406 ? 9.03587   -26.14162 -29.72770 1.000 38.64437 ? 388  GLU   B C   1 
ATOM   6686 O O   . GLU   B 1 406 ? 9.56423   -26.97056 -30.46671 1.000 56.79099 ? 388  GLU   B O   1 
ATOM   6687 C CB  . GLU   B 1 406 ? 7.52384   -26.25818 -27.73254 1.000 42.90128 ? 388  GLU   B CB  1 
ATOM   6688 C CG  . GLU   B 1 406 ? 7.37482   -26.24236 -26.21803 1.000 40.90973 ? 388  GLU   B CG  1 
ATOM   6689 C CD  . GLU   B 1 406 ? 6.11699   -25.52045 -25.74968 1.000 51.70094 ? 388  GLU   B CD  1 
ATOM   6690 O OE1 . GLU   B 1 406 ? 5.14938   -25.40267 -26.53707 1.000 47.01000 ? 388  GLU   B OE1 1 
ATOM   6691 O OE2 . GLU   B 1 406 ? 6.10004   -25.06695 -24.58467 1.000 50.38147 ? 388  GLU   B OE2 1 
ATOM   6692 N N   . GLY   B 1 419 ? 19.44726  -16.48967 -25.17253 1.000 29.39087 ? 401  GLY   B N   1 
ATOM   6693 C CA  . GLY   B 1 419 ? 19.73884  -15.38673 -24.27042 1.000 24.58103 ? 401  GLY   B CA  1 
ATOM   6694 C C   . GLY   B 1 419 ? 18.51432  -14.63713 -23.76215 1.000 30.86915 ? 401  GLY   B C   1 
ATOM   6695 O O   . GLY   B 1 419 ? 18.53879  -13.40909 -23.64818 1.000 24.16137 ? 401  GLY   B O   1 
ATOM   6696 N N   . SER   B 1 420 ? 17.44985  -15.37712 -23.43860 1.000 18.80886 ? 402  SER   B N   1 
ATOM   6697 C CA  . SER   B 1 420 ? 16.21452  -14.75068 -22.98171 1.000 19.52224 ? 402  SER   B CA  1 
ATOM   6698 C C   . SER   B 1 420 ? 16.42364  -14.02774 -21.65957 1.000 17.53290 ? 402  SER   B C   1 
ATOM   6699 O O   . SER   B 1 420 ? 17.07957  -14.54223 -20.74550 1.000 15.57793 ? 402  SER   B O   1 
ATOM   6700 C CB  . SER   B 1 420 ? 15.10804  -15.79383 -22.81411 1.000 21.63927 ? 402  SER   B CB  1 
ATOM   6701 O OG  . SER   B 1 420 ? 13.99261  -15.22624 -22.14179 1.000 18.93509 ? 402  SER   B OG  1 
ATOM   6702 N N   . ALA   B 1 421 ? 15.82547  -12.83532 -21.55256 1.000 17.56059 ? 403  ALA   B N   1 
ATOM   6703 C CA  . ALA   B 1 421 ? 15.89378  -12.07409 -20.31170 1.000 15.72081 ? 403  ALA   B CA  1 
ATOM   6704 C C   . ALA   B 1 421 ? 15.38042  -12.87740 -19.12923 1.000 11.21013 ? 403  ALA   B C   1 
ATOM   6705 O O   . ALA   B 1 421 ? 15.86071  -12.70142 -18.00859 1.000 16.78985 ? 403  ALA   B O   1 
ATOM   6706 C CB  . ALA   B 1 421 ? 15.09556  -10.77427 -20.44826 1.000 15.51811 ? 403  ALA   B CB  1 
ATOM   6707 N N   . LEU   B 1 422 ? 14.40770  -13.75962 -19.35364 1.000 13.62583 ? 404  LEU   B N   1 
ATOM   6708 C CA  . LEU   B 1 422 ? 13.80160  -14.49726 -18.24850 1.000 19.14393 ? 404  LEU   B CA  1 
ATOM   6709 C C   . LEU   B 1 422 ? 14.73247  -15.53859 -17.63742 1.000 16.97679 ? 404  LEU   B C   1 
ATOM   6710 O O   . LEU   B 1 422 ? 14.46582  -16.01383 -16.52577 1.000 15.83091 ? 404  LEU   B O   1 
ATOM   6711 C CB  . LEU   B 1 422 ? 12.51730  -15.17502 -18.71153 1.000 17.09414 ? 404  LEU   B CB  1 
ATOM   6712 C CG  . LEU   B 1 422 ? 11.42822  -14.24409 -19.24313 1.000 14.23469 ? 404  LEU   B CG  1 
ATOM   6713 C CD1 . LEU   B 1 422 ? 10.14323  -15.03351 -19.40347 1.000 15.45647 ? 404  LEU   B CD1 1 
ATOM   6714 C CD2 . LEU   B 1 422 ? 11.21994  -13.05936 -18.30867 1.000 18.80695 ? 404  LEU   B CD2 1 
ATOM   6715 N N   . GLN   B 1 423 ? 15.80012  -15.92003 -18.32606 1.000 15.31169 ? 405  GLN   B N   1 
ATOM   6716 C CA  . GLN   B 1 423 ? 16.76673  -16.83382 -17.73850 1.000 20.21290 ? 405  GLN   B CA  1 
ATOM   6717 C C   . GLN   B 1 423 ? 18.00856  -16.10882 -17.26294 1.000 23.86353 ? 405  GLN   B C   1 
ATOM   6718 O O   . GLN   B 1 423 ? 19.02329  -16.75546 -16.97634 1.000 17.89191 ? 405  GLN   B O   1 
ATOM   6719 C CB  . GLN   B 1 423 ? 17.14166  -17.93600 -18.73288 1.000 25.28339 ? 405  GLN   B CB  1 
ATOM   6720 C CG  . GLN   B 1 423 ? 15.96219  -18.47649 -19.52970 1.000 22.11881 ? 405  GLN   B CG  1 
ATOM   6721 C CD  . GLN   B 1 423 ? 16.35873  -19.60493 -20.47083 1.000 32.48813 ? 405  GLN   B CD  1 
ATOM   6722 O OE1 . GLN   B 1 423 ? 16.93534  -19.37024 -21.53360 1.000 33.94691 ? 405  GLN   B OE1 1 
ATOM   6723 N NE2 . GLN   B 1 423 ? 16.01689  -20.83009 -20.09975 1.000 36.45204 ? 405  GLN   B NE2 1 
ATOM   6724 N N   . ASP   B 1 424 ? 17.94634  -14.78240 -17.16279 1.000 16.85902 ? 406  ASP   B N   1 
ATOM   6725 C CA  . ASP   B 1 424 ? 19.09944  -13.96634 -16.80671 1.000 16.50205 ? 406  ASP   B CA  1 
ATOM   6726 C C   . ASP   B 1 424 ? 18.89438  -13.40039 -15.41248 1.000 20.21574 ? 406  ASP   B C   1 
ATOM   6727 O O   . ASP   B 1 424 ? 18.06634  -12.48803 -15.23634 1.000 15.08057 ? 406  ASP   B O   1 
ATOM   6728 C CB  . ASP   B 1 424 ? 19.28725  -12.83480 -17.81973 1.000 19.28484 ? 406  ASP   B CB  1 
ATOM   6729 C CG  . ASP   B 1 424 ? 20.51652  -11.99533 -17.54085 1.000 17.44713 ? 406  ASP   B CG  1 
ATOM   6730 O OD1 . ASP   B 1 424 ? 21.23282  -12.27469 -16.55353 1.000 17.03262 ? 406  ASP   B OD1 1 
ATOM   6731 O OD2 . ASP   B 1 424 ? 20.76643  -11.04576 -18.31888 1.000 20.60739 ? 406  ASP   B OD2 1 
ATOM   6732 N N   . PRO   B 1 425 ? 19.62013  -13.89111 -14.40465 1.000 19.48511 ? 407  PRO   B N   1 
ATOM   6733 C CA  . PRO   B 1 425 ? 19.43885  -13.35973 -13.04413 1.000 18.91173 ? 407  PRO   B CA  1 
ATOM   6734 C C   . PRO   B 1 425 ? 19.68401  -11.86740 -12.94879 1.000 18.61483 ? 407  PRO   B C   1 
ATOM   6735 O O   . PRO   B 1 425 ? 19.13481  -11.21672 -12.05022 1.000 13.89408 ? 407  PRO   B O   1 
ATOM   6736 C CB  . PRO   B 1 425 ? 20.46052  -14.15653 -12.21279 1.000 19.13565 ? 407  PRO   B CB  1 
ATOM   6737 C CG  . PRO   B 1 425 ? 20.81268  -15.35425 -13.05587 1.000 17.53634 ? 407  PRO   B CG  1 
ATOM   6738 C CD  . PRO   B 1 425 ? 20.68753  -14.90545 -14.47518 1.000 20.02257 ? 407  PRO   B CD  1 
ATOM   6739 N N   . GLU   B 1 426 ? 20.48750  -11.30116 -13.85359 1.000 14.17771 ? 408  GLU   B N   1 
ATOM   6740 C CA  . GLU   B 1 426 ? 20.69360  -9.85998  -13.83229 1.000 14.47529 ? 408  GLU   B CA  1 
ATOM   6741 C C   . GLU   B 1 426 ? 19.46074  -9.10963  -14.31866 1.000 16.36646 ? 408  GLU   B C   1 
ATOM   6742 O O   . GLU   B 1 426 ? 19.22467  -7.97174  -13.89325 1.000 17.42583 ? 408  GLU   B O   1 
ATOM   6743 C CB  . GLU   B 1 426 ? 21.91196  -9.47469  -14.66978 1.000 15.09501 ? 408  GLU   B CB  1 
ATOM   6744 C CG  . GLU   B 1 426 ? 22.31461  -8.01817  -14.48191 1.000 17.32363 ? 408  GLU   B CG  1 
ATOM   6745 C CD  . GLU   B 1 426 ? 23.01196  -7.77362  -13.15605 1.000 28.59303 ? 408  GLU   B CD  1 
ATOM   6746 O OE1 . GLU   B 1 426 ? 23.19162  -8.73948  -12.37749 1.000 23.41072 ? 408  GLU   B OE1 1 
ATOM   6747 O OE2 . GLU   B 1 426 ? 23.36764  -6.60581  -12.88777 1.000 34.35843 ? 408  GLU   B OE2 1 
ATOM   6748 N N   . CYS   B 1 427 ? 18.66445  -9.72066  -15.20097 1.000 13.10282 ? 409  CYS   B N   1 
ATOM   6749 C CA  . CYS   B 1 427 ? 17.40202  -9.09639  -15.58076 1.000 15.47193 ? 409  CYS   B CA  1 
ATOM   6750 C C   . CYS   B 1 427 ? 16.40080  -9.16074  -14.43903 1.000 17.71993 ? 409  CYS   B C   1 
ATOM   6751 O O   . CYS   B 1 427 ? 15.63028  -8.21781  -14.22406 1.000 13.72209 ? 409  CYS   B O   1 
ATOM   6752 C CB  . CYS   B 1 427 ? 16.83690  -9.75847  -16.83474 1.000 14.09849 ? 409  CYS   B CB  1 
ATOM   6753 S SG  . CYS   B 1 427 ? 17.72040  -9.25329  -18.32325 1.000 16.84452 ? 409  CYS   B SG  1 
ATOM   6754 N N   . PHE   B 1 428 ? 16.39175  -10.26477 -13.69304 1.000 12.63343 ? 410  PHE   B N   1 
ATOM   6755 C CA  . PHE   B 1 428 ? 15.59477  -10.28730 -12.47622 1.000 14.30202 ? 410  PHE   B CA  1 
ATOM   6756 C C   . PHE   B 1 428 ? 16.06302  -9.20056  -11.51481 1.000 18.95053 ? 410  PHE   B C   1 
ATOM   6757 O O   . PHE   B 1 428 ? 15.24222  -8.54159  -10.86473 1.000 10.66690 ? 410  PHE   B O   1 
ATOM   6758 C CB  . PHE   B 1 428 ? 15.65597  -11.67080 -11.82209 1.000 12.42009 ? 410  PHE   B CB  1 
ATOM   6759 C CG  . PHE   B 1 428 ? 14.76616  -11.80129 -10.61675 1.000 14.66347 ? 410  PHE   B CG  1 
ATOM   6760 C CD1 . PHE   B 1 428 ? 13.38762  -11.60843 -10.73390 1.000 11.75178 ? 410  PHE   B CD1 1 
ATOM   6761 C CD2 . PHE   B 1 428 ? 15.30317  -12.08955 -9.36828  1.000 14.90483 ? 410  PHE   B CD2 1 
ATOM   6762 C CE1 . PHE   B 1 428 ? 12.55688  -11.72459 -9.62181  1.000 13.52921 ? 410  PHE   B CE1 1 
ATOM   6763 C CE2 . PHE   B 1 428 ? 14.48583  -12.20959 -8.24910  1.000 16.02027 ? 410  PHE   B CE2 1 
ATOM   6764 C CZ  . PHE   B 1 428 ? 13.11069  -12.01831 -8.37005  1.000 15.76845 ? 410  PHE   B CZ  1 
ATOM   6765 N N   . ALA   B 1 429 ? 17.38093  -8.96465  -11.44608 1.000 12.92233 ? 411  ALA   B N   1 
ATOM   6766 C CA  . ALA   B 1 429 ? 17.89372  -7.89793  -10.58667 1.000 14.31571 ? 411  ALA   B CA  1 
ATOM   6767 C C   . ALA   B 1 429 ? 17.41658  -6.52639  -11.04649 1.000 12.09871 ? 411  ALA   B C   1 
ATOM   6768 O O   . ALA   B 1 429 ? 17.10381  -5.66925  -10.21428 1.000 10.92211 ? 411  ALA   B O   1 
ATOM   6769 C CB  . ALA   B 1 429 ? 19.42212  -7.92969  -10.53911 1.000 16.99359 ? 411  ALA   B CB  1 
ATOM   6770 N N   . HIS   B 1 430 ? 17.38265  -6.28692  -12.36260 1.000 10.77997 ? 412  HIS   B N   1 
ATOM   6771 C CA  . HIS   B 1 430 ? 16.86539  -5.01265  -12.85914 1.000 12.47296 ? 412  HIS   B CA  1 
ATOM   6772 C C   . HIS   B 1 430 ? 15.43368  -4.78062  -12.38180 1.000 11.34596 ? 412  HIS   B C   1 
ATOM   6773 O O   . HIS   B 1 430 ? 15.08051  -3.67080  -11.96388 1.000 11.21351 ? 412  HIS   B O   1 
ATOM   6774 C CB  . HIS   B 1 430 ? 16.90429  -4.96350  -14.39012 1.000 12.77599 ? 412  HIS   B CB  1 
ATOM   6775 C CG  . HIS   B 1 430 ? 18.27820  -5.04114  -14.98108 1.000 14.72661 ? 412  HIS   B CG  1 
ATOM   6776 N ND1 . HIS   B 1 430 ? 19.41481  -4.68341  -14.28715 1.000 15.13253 ? 412  HIS   B ND1 1 
ATOM   6777 C CD2 . HIS   B 1 430 ? 18.69512  -5.43593  -16.20918 1.000 17.35122 ? 412  HIS   B CD2 1 
ATOM   6778 C CE1 . HIS   B 1 430 ? 20.47475  -4.86342  -15.05920 1.000 19.25249 ? 412  HIS   B CE1 1 
ATOM   6779 N NE2 . HIS   B 1 430 ? 20.06563  -5.31527  -16.23307 1.000 15.63716 ? 412  HIS   B NE2 1 
ATOM   6780 N N   . LEU   B 1 431 ? 14.59352  -5.81653  -12.45912 1.000 12.86739 ? 413  LEU   B N   1 
ATOM   6781 C CA  . LEU   B 1 431 ? 13.20956  -5.70271  -12.00306 1.000 10.93254 ? 413  LEU   B CA  1 
ATOM   6782 C C   . LEU   B 1 431 ? 13.15442  -5.31133  -10.53448 1.000 11.75281 ? 413  LEU   B C   1 
ATOM   6783 O O   . LEU   B 1 431 ? 12.46977  -4.35300  -10.15830 1.000 11.69789 ? 413  LEU   B O   1 
ATOM   6784 C CB  . LEU   B 1 431 ? 12.48040  -7.02978  -12.22864 1.000 8.39289  ? 413  LEU   B CB  1 
ATOM   6785 C CG  . LEU   B 1 431 ? 11.02280  -7.09847  -11.75316 1.000 12.24300 ? 413  LEU   B CG  1 
ATOM   6786 C CD1 . LEU   B 1 431 ? 10.11379  -6.24168  -12.65032 1.000 10.89777 ? 413  LEU   B CD1 1 
ATOM   6787 C CD2 . LEU   B 1 431 ? 10.53857  -8.54992  -11.68730 1.000 12.60855 ? 413  LEU   B CD2 1 
ATOM   6788 N N   . LEU   B 1 432 ? 13.89169  -6.03938  -9.69082  1.000 12.87320 ? 414  LEU   B N   1 
ATOM   6789 C CA  . LEU   B 1 432 ? 13.88470  -5.76601  -8.25662  1.000 12.84062 ? 414  LEU   B CA  1 
ATOM   6790 C C   . LEU   B 1 432 ? 14.46149  -4.39005  -7.94546  1.000 13.09317 ? 414  LEU   B C   1 
ATOM   6791 O O   . LEU   B 1 432 ? 13.95663  -3.68357  -7.05994  1.000 13.83521 ? 414  LEU   B O   1 
ATOM   6792 C CB  . LEU   B 1 432 ? 14.66467  -6.85810  -7.51608  1.000 12.97836 ? 414  LEU   B CB  1 
ATOM   6793 C CG  . LEU   B 1 432 ? 14.09872  -8.28349  -7.61597  1.000 12.40686 ? 414  LEU   B CG  1 
ATOM   6794 C CD1 . LEU   B 1 432 ? 14.80389  -9.18246  -6.63291  1.000 11.71584 ? 414  LEU   B CD1 1 
ATOM   6795 C CD2 . LEU   B 1 432 ? 12.59902  -8.28690  -7.36491  1.000 15.59640 ? 414  LEU   B CD2 1 
ATOM   6796 N N   . ARG   B 1 433 ? 15.52864  -3.99726  -8.65137  1.000 10.35600 ? 415  ARG   B N   1 
ATOM   6797 C CA  . ARG   B 1 433 ? 16.09278  -2.66749  -8.45471  1.000 14.62773 ? 415  ARG   B CA  1 
ATOM   6798 C C   . ARG   B 1 433 ? 15.07718  -1.58625  -8.79673  1.000 11.50218 ? 415  ARG   B C   1 
ATOM   6799 O O   . ARG   B 1 433 ? 15.00752  -0.55101  -8.12609  1.000 13.70288 ? 415  ARG   B O   1 
ATOM   6800 C CB  . ARG   B 1 433 ? 17.34264  -2.48807  -9.31223  1.000 18.52625 ? 415  ARG   B CB  1 
ATOM   6801 C CG  . ARG   B 1 433 ? 17.94339  -1.09955  -9.17329  1.000 22.43503 ? 415  ARG   B CG  1 
ATOM   6802 C CD  . ARG   B 1 433 ? 19.29241  -1.17956  -8.50714  1.000 32.57957 ? 415  ARG   B CD  1 
ATOM   6803 N NE  . ARG   B 1 433 ? 20.09860  -2.22360  -9.12846  1.000 43.47805 ? 415  ARG   B NE  1 
ATOM   6804 C CZ  . ARG   B 1 433 ? 20.86978  -3.06885  -8.45972  1.000 43.52506 ? 415  ARG   B CZ  1 
ATOM   6805 N NH1 . ARG   B 1 433 ? 20.98265  -3.00452  -7.14135  1.000 37.41301 ? 415  ARG   B NH1 1 
ATOM   6806 N NH2 . ARG   B 1 433 ? 21.53041  -4.01212  -9.12816  1.000 33.41928 ? 415  ARG   B NH2 1 
ATOM   6807 N N   . PHE   B 1 434 ? 14.29724  -1.80846  -9.85392  1.000 11.30302 ? 416  PHE   B N   1 
ATOM   6808 C CA  . PHE   B 1 434 ? 13.22856  -0.88760  -10.22765 1.000 11.31128 ? 416  PHE   B CA  1 
ATOM   6809 C C   . PHE   B 1 434 ? 12.24051  -0.70234  -9.08144  1.000 17.55411 ? 416  PHE   B C   1 
ATOM   6810 O O   . PHE   B 1 434 ? 11.90983  0.43187   -8.70500  1.000 13.59405 ? 416  PHE   B O   1 
ATOM   6811 C CB  . PHE   B 1 434 ? 12.53693  -1.42150  -11.48237 1.000 11.88471 ? 416  PHE   B CB  1 
ATOM   6812 C CG  . PHE   B 1 434 ? 11.34100  -0.63543  -11.91592 1.000 17.37781 ? 416  PHE   B CG  1 
ATOM   6813 C CD1 . PHE   B 1 434 ? 11.49272  0.51860   -12.66046 1.000 16.71974 ? 416  PHE   B CD1 1 
ATOM   6814 C CD2 . PHE   B 1 434 ? 10.06369  -1.07616  -11.62343 1.000 15.83049 ? 416  PHE   B CD2 1 
ATOM   6815 C CE1 . PHE   B 1 434 ? 10.39675  1.22675   -13.08591 1.000 14.94168 ? 416  PHE   B CE1 1 
ATOM   6816 C CE2 . PHE   B 1 434 ? 8.96913   -0.35854  -12.03584 1.000 19.34118 ? 416  PHE   B CE2 1 
ATOM   6817 C CZ  . PHE   B 1 434 ? 9.14133   0.79166   -12.76626 1.000 8.64572  ? 416  PHE   B CZ  1 
ATOM   6818 N N   . TYR   B 1 435 ? 11.76956  -1.81101  -8.49744  1.000 11.95074 ? 417  TYR   B N   1 
ATOM   6819 C CA  . TYR   B 1 435 ? 10.85556  -1.69887  -7.36458  1.000 12.78865 ? 417  TYR   B CA  1 
ATOM   6820 C C   . TYR   B 1 435 ? 11.56247  -1.12335  -6.14082  1.000 15.15099 ? 417  TYR   B C   1 
ATOM   6821 O O   . TYR   B 1 435 ? 10.95851  -0.36457  -5.37607  1.000 12.06388 ? 417  TYR   B O   1 
ATOM   6822 C CB  . TYR   B 1 435 ? 10.23052  -3.06027  -7.05035  1.000 12.97550 ? 417  TYR   B CB  1 
ATOM   6823 C CG  . TYR   B 1 435 ? 9.07109   -3.38299  -7.96182  1.000 13.47294 ? 417  TYR   B CG  1 
ATOM   6824 C CD1 . TYR   B 1 435 ? 7.78152   -2.95941  -7.65355  1.000 12.37038 ? 417  TYR   B CD1 1 
ATOM   6825 C CD2 . TYR   B 1 435 ? 9.26715   -4.08540  -9.14564  1.000 13.17102 ? 417  TYR   B CD2 1 
ATOM   6826 C CE1 . TYR   B 1 435 ? 6.71151   -3.23632  -8.49914  1.000 13.48788 ? 417  TYR   B CE1 1 
ATOM   6827 C CE2 . TYR   B 1 435 ? 8.19794   -4.37176  -9.99683  1.000 14.83675 ? 417  TYR   B CE2 1 
ATOM   6828 C CZ  . TYR   B 1 435 ? 6.92685   -3.93757  -9.66678  1.000 12.30114 ? 417  TYR   B CZ  1 
ATOM   6829 O OH  . TYR   B 1 435 ? 5.86458   -4.21586  -10.50250 1.000 14.85226 ? 417  TYR   B OH  1 
ATOM   6830 N N   . ASP   B 1 436 ? 12.84446  -1.45825  -5.94692  1.000 10.06113 ? 418  ASP   B N   1 
ATOM   6831 C CA  . ASP   B 1 436 ? 13.59696  -0.88519  -4.82923  1.000 15.02760 ? 418  ASP   B CA  1 
ATOM   6832 C C   . ASP   B 1 436 ? 13.58705  0.64289   -4.87953  1.000 13.93516 ? 418  ASP   B C   1 
ATOM   6833 O O   . ASP   B 1 436 ? 13.36642  1.31073   -3.86142  1.000 13.61294 ? 418  ASP   B O   1 
ATOM   6834 C CB  . ASP   B 1 436 ? 15.03900  -1.42050  -4.83586  1.000 17.79273 ? 418  ASP   B CB  1 
ATOM   6835 C CG  . ASP   B 1 436 ? 15.76564  -1.19261  -3.51180  1.000 13.91936 ? 418  ASP   B CG  1 
ATOM   6836 O OD1 . ASP   B 1 436 ? 15.14213  -1.37203  -2.44654  1.000 14.90329 ? 418  ASP   B OD1 1 
ATOM   6837 O OD2 . ASP   B 1 436 ? 16.97126  -0.84724  -3.53358  1.000 16.64919 ? 418  ASP   B OD2 1 
ATOM   6838 N N   . GLY   B 1 437 ? 13.83135  1.21893   -6.05806  1.000 9.64000  ? 419  GLY   B N   1 
ATOM   6839 C CA  . GLY   B 1 437 ? 13.88666  2.67254   -6.15133  1.000 11.11819 ? 419  GLY   B CA  1 
ATOM   6840 C C   . GLY   B 1 437 ? 12.54571  3.32762   -5.87286  1.000 10.96678 ? 419  GLY   B C   1 
ATOM   6841 O O   . GLY   B 1 437 ? 12.47111  4.34242   -5.16939  1.000 13.29809 ? 419  GLY   B O   1 
ATOM   6842 N N   . ILE   B 1 438 ? 11.46941  2.75731   -6.41580  1.000 10.50514 ? 420  ILE   B N   1 
ATOM   6843 C CA  . ILE   B 1 438 ? 10.12734  3.26977   -6.14081  1.000 11.88987 ? 420  ILE   B CA  1 
ATOM   6844 C C   . ILE   B 1 438 ? 9.80518   3.18021   -4.65197  1.000 18.12482 ? 420  ILE   B C   1 
ATOM   6845 O O   . ILE   B 1 438 ? 9.19385   4.09368   -4.08151  1.000 15.88442 ? 420  ILE   B O   1 
ATOM   6846 C CB  . ILE   B 1 438 ? 9.08726   2.53102   -7.00509  1.000 14.75101 ? 420  ILE   B CB  1 
ATOM   6847 C CG1 . ILE   B 1 438 ? 9.35770   2.79382   -8.48921  1.000 18.83957 ? 420  ILE   B CG1 1 
ATOM   6848 C CG2 . ILE   B 1 438 ? 7.65830   2.93722   -6.64321  1.000 14.66123 ? 420  ILE   B CG2 1 
ATOM   6849 C CD1 . ILE   B 1 438 ? 8.65220   1.86015   -9.40026  1.000 18.24931 ? 420  ILE   B CD1 1 
ATOM   6850 N N   . CYS   B 1 439 ? 10.20377  2.08629   -3.99581  1.000 13.02451 ? 421  CYS   B N   1 
ATOM   6851 C CA  . CYS   B 1 439 ? 9.96098   1.97446   -2.55758  1.000 12.61478 ? 421  CYS   B CA  1 
ATOM   6852 C C   . CYS   B 1 439 ? 10.73460  3.03042   -1.78423  1.000 11.33499 ? 421  CYS   B C   1 
ATOM   6853 O O   . CYS   B 1 439 ? 10.22877  3.60432   -0.81254  1.000 13.20878 ? 421  CYS   B O   1 
ATOM   6854 C CB  . CYS   B 1 439 ? 10.34053  0.57609   -2.06220  1.000 10.29181 ? 421  CYS   B CB  1 
ATOM   6855 S SG  . CYS   B 1 439 ? 9.13246   -0.67998  -2.51053  1.000 15.23256 ? 421  CYS   B SG  1 
ATOM   6856 N N   . LYS   B 1 440 ? 11.96846  3.29683   -2.19932  1.000 13.46399 ? 422  LYS   B N   1 
ATOM   6857 C CA  . LYS   B 1 440 ? 12.78639  4.25838   -1.47722  1.000 14.64045 ? 422  LYS   B CA  1 
ATOM   6858 C C   . LYS   B 1 440 ? 12.25253  5.66725   -1.68224  1.000 15.40723 ? 422  LYS   B C   1 
ATOM   6859 O O   . LYS   B 1 440 ? 12.21689  6.47137   -0.74164  1.000 14.70992 ? 422  LYS   B O   1 
ATOM   6860 C CB  . LYS   B 1 440 ? 14.23171  4.11500   -1.94702  1.000 14.50718 ? 422  LYS   B CB  1 
ATOM   6861 C CG  . LYS   B 1 440 ? 15.24431  4.95405   -1.23916  1.000 29.42619 ? 422  LYS   B CG  1 
ATOM   6862 C CD  . LYS   B 1 440 ? 15.47093  4.48691   0.16778   1.000 31.52446 ? 422  LYS   B CD  1 
ATOM   6863 C CE  . LYS   B 1 440 ? 16.33120  5.49849   0.89713   1.000 37.39371 ? 422  LYS   B CE  1 
ATOM   6864 N NZ  . LYS   B 1 440 ? 17.67901  5.50535   0.26519   1.000 40.25706 ? 422  LYS   B NZ  1 
ATOM   6865 N N   . TRP   B 1 441 ? 11.80939  5.96453   -2.90996  1.000 10.73834 ? 423  TRP   B N   1 
ATOM   6866 C CA  . TRP   B 1 441 ? 11.13536  7.22341   -3.22703  1.000 13.67126 ? 423  TRP   B CA  1 
ATOM   6867 C C   . TRP   B 1 441 ? 9.95996   7.50388   -2.28891  1.000 15.32882 ? 423  TRP   B C   1 
ATOM   6868 O O   . TRP   B 1 441 ? 9.77698   8.63601   -1.82808  1.000 16.60866 ? 423  TRP   B O   1 
ATOM   6869 C CB  . TRP   B 1 441 ? 10.65315  7.15572   -4.67958  1.000 19.25857 ? 423  TRP   B CB  1 
ATOM   6870 C CG  . TRP   B 1 441 ? 10.05361  8.39902   -5.27520  1.000 12.96746 ? 423  TRP   B CG  1 
ATOM   6871 C CD1 . TRP   B 1 441 ? 10.39574  9.69791   -5.02387  1.000 13.34285 ? 423  TRP   B CD1 1 
ATOM   6872 C CD2 . TRP   B 1 441 ? 9.03146   8.43796   -6.27810  1.000 11.42770 ? 423  TRP   B CD2 1 
ATOM   6873 N NE1 . TRP   B 1 441 ? 9.63406   10.54386  -5.80867  1.000 11.27950 ? 423  TRP   B NE1 1 
ATOM   6874 C CE2 . TRP   B 1 441 ? 8.79146   9.79133   -6.58379  1.000 10.44202 ? 423  TRP   B CE2 1 
ATOM   6875 C CE3 . TRP   B 1 441 ? 8.30121   7.45377   -6.95136  1.000 13.14173 ? 423  TRP   B CE3 1 
ATOM   6876 C CZ2 . TRP   B 1 441 ? 7.83969   10.18580  -7.52431  1.000 11.20450 ? 423  TRP   B CZ2 1 
ATOM   6877 C CZ3 . TRP   B 1 441 ? 7.35488   7.84271   -7.88022  1.000 17.47201 ? 423  TRP   B CZ3 1 
ATOM   6878 C CH2 . TRP   B 1 441 ? 7.13321   9.19904   -8.16093  1.000 15.35278 ? 423  TRP   B CH2 1 
ATOM   6879 N N   . GLU   B 1 442 ? 9.14273   6.48647   -2.00914  1.000 14.63305 ? 424  GLU   B N   1 
ATOM   6880 C CA  . GLU   B 1 442 ? 7.95535   6.66240   -1.18212  1.000 17.15722 ? 424  GLU   B CA  1 
ATOM   6881 C C   . GLU   B 1 442 ? 8.29694   6.88837   0.28668   1.000 18.12108 ? 424  GLU   B C   1 
ATOM   6882 O O   . GLU   B 1 442 ? 7.47971   7.45652   1.02451   1.000 22.67097 ? 424  GLU   B O   1 
ATOM   6883 C CB  . GLU   B 1 442 ? 7.04640   5.43848   -1.34721  1.000 22.10923 ? 424  GLU   B CB  1 
ATOM   6884 C CG  . GLU   B 1 442 ? 5.89571   5.31304   -0.36428  1.000 20.40780 ? 424  GLU   B CG  1 
ATOM   6885 C CD  . GLU   B 1 442 ? 5.23217   3.94963   -0.43934  1.000 18.71916 ? 424  GLU   B CD  1 
ATOM   6886 O OE1 . GLU   B 1 442 ? 5.83660   2.96153   0.05211   1.000 21.51265 ? 424  GLU   B OE1 1 
ATOM   6887 O OE2 . GLU   B 1 442 ? 4.11211   3.86237   -0.98472  1.000 24.20694 ? 424  GLU   B OE2 1 
ATOM   6888 N N   . GLU   B 1 443 ? 9.48665   6.48165   0.71964   1.000 19.66933 ? 425  GLU   B N   1 
ATOM   6889 C CA  . GLU   B 1 443 ? 9.84622   6.57664   2.13009   1.000 24.40917 ? 425  GLU   B CA  1 
ATOM   6890 C C   . GLU   B 1 443 ? 9.78613   8.02045   2.61004   1.000 27.49560 ? 425  GLU   B C   1 
ATOM   6891 O O   . GLU   B 1 443 ? 10.32764  8.92725   1.97029   1.000 25.34082 ? 425  GLU   B O   1 
ATOM   6892 C CB  . GLU   B 1 443 ? 11.23891  5.99457   2.36047   1.000 18.64811 ? 425  GLU   B CB  1 
ATOM   6893 C CG  . GLU   B 1 443 ? 11.21667  4.48946   2.58993   1.000 26.64055 ? 425  GLU   B CG  1 
ATOM   6894 C CD  . GLU   B 1 443 ? 12.60382  3.89147   2.71162   1.000 30.71174 ? 425  GLU   B CD  1 
ATOM   6895 O OE1 . GLU   B 1 443 ? 13.51104  4.59957   3.19150   1.000 26.82418 ? 425  GLU   B OE1 1 
ATOM   6896 O OE2 . GLU   B 1 443 ? 12.78527  2.71411   2.32797   1.000 23.73006 ? 425  GLU   B OE2 1 
ATOM   6897 N N   . GLY   B 1 444 ? 9.11928   8.22659   3.74581   1.000 32.50367 ? 426  GLY   B N   1 
ATOM   6898 C CA  . GLY   B 1 444 ? 8.89981   9.54636   4.29471   1.000 26.52380 ? 426  GLY   B CA  1 
ATOM   6899 C C   . GLY   B 1 444 ? 7.66337   10.24625  3.78148   1.000 31.38653 ? 426  GLY   B C   1 
ATOM   6900 O O   . GLY   B 1 444 ? 7.40088   11.38450  4.19295   1.000 29.10888 ? 426  GLY   B O   1 
ATOM   6901 N N   . SER   B 1 445 ? 6.89562   9.61170   2.90263   1.000 28.92565 ? 427  SER   B N   1 
ATOM   6902 C CA  . SER   B 1 445 ? 5.81918   10.46367  2.41977   1.000 35.18670 ? 427  SER   B CA  1 
ATOM   6903 C C   . SER   B 1 445 ? 4.51019   10.12910  3.12502   1.000 36.62593 ? 427  SER   B C   1 
ATOM   6904 O O   . SER   B 1 445 ? 4.25706   8.96224   3.44369   1.000 38.44612 ? 427  SER   B O   1 
ATOM   6905 C CB  . SER   B 1 445 ? 5.64565   10.30834  0.90586   1.000 34.49657 ? 427  SER   B CB  1 
ATOM   6906 O OG  . SER   B 1 445 ? 4.57011   9.44851   0.58040   1.000 43.15347 ? 427  SER   B OG  1 
ATOM   6907 N N   . PRO   B 1 446 ? 3.65345   11.12216  3.37986   1.000 39.07225 ? 428  PRO   B N   1 
ATOM   6908 C CA  . PRO   B 1 446 ? 2.39403   10.82924  4.07853   1.000 39.63008 ? 428  PRO   B CA  1 
ATOM   6909 C C   . PRO   B 1 446 ? 1.38718   10.10410  3.21082   1.000 45.33338 ? 428  PRO   B C   1 
ATOM   6910 O O   . PRO   B 1 446 ? 0.49757   9.43014   3.74736   1.000 56.21081 ? 428  PRO   B O   1 
ATOM   6911 C CB  . PRO   B 1 446 ? 1.88623   12.21814  4.48776   1.000 45.08876 ? 428  PRO   B CB  1 
ATOM   6912 C CG  . PRO   B 1 446 ? 2.54516   13.18473  3.52891   1.000 48.52637 ? 428  PRO   B CG  1 
ATOM   6913 C CD  . PRO   B 1 446 ? 3.65570   12.47272  2.78962   1.000 43.89528 ? 428  PRO   B CD  1 
ATOM   6914 N N   . THR   B 1 447 ? 1.50129   10.21818  1.89616   1.000 28.31466 ? 429  THR   B N   1 
ATOM   6915 C CA  . THR   B 1 447 ? 0.70260   9.60733   0.85043   1.000 39.36083 ? 429  THR   B CA  1 
ATOM   6916 C C   . THR   B 1 447 ? 1.43097   8.40060   0.26945   1.000 25.57199 ? 429  THR   B C   1 
ATOM   6917 O O   . THR   B 1 447 ? 2.64741   8.44277   0.08038   1.000 28.40275 ? 429  THR   B O   1 
ATOM   6918 C CB  . THR   B 1 447 ? 0.40503   10.62811  -0.25390  1.000 37.56066 ? 429  THR   B CB  1 
ATOM   6919 O OG1 . THR   B 1 447 ? -0.22665  9.98578   -1.37134  1.000 53.00888 ? 429  THR   B OG1 1 
ATOM   6920 C CG2 . THR   B 1 447 ? 1.67910   11.35595  -0.69038  1.000 39.76117 ? 429  THR   B CG2 1 
ATOM   6921 N N   . PRO   B 1 448 ? 0.73664   7.30127   0.00606   1.000 32.31585 ? 430  PRO   B N   1 
ATOM   6922 C CA  . PRO   B 1 448 ? 1.41497   6.11871   -0.52957  1.000 29.26295 ? 430  PRO   B CA  1 
ATOM   6923 C C   . PRO   B 1 448 ? 1.65935   6.21017   -2.02855  1.000 24.88427 ? 430  PRO   B C   1 
ATOM   6924 O O   . PRO   B 1 448 ? 0.87239   6.77973   -2.79077  1.000 21.18735 ? 430  PRO   B O   1 
ATOM   6925 C CB  . PRO   B 1 448 ? 0.44139   4.98183   -0.19656  1.000 35.67207 ? 430  PRO   B CB  1 
ATOM   6926 C CG  . PRO   B 1 448 ? -0.91166  5.64224   -0.21055  1.000 28.19567 ? 430  PRO   B CG  1 
ATOM   6927 C CD  . PRO   B 1 448 ? -0.68359  7.04571   0.30859   1.000 33.17774 ? 430  PRO   B CD  1 
ATOM   6928 N N   . VAL   B 1 449 ? 2.78729   5.64904   -2.44806  1.000 17.08627 ? 431  VAL   B N   1 
ATOM   6929 C CA  . VAL   B 1 449 ? 2.99000   5.36540   -3.86208  1.000 20.00869 ? 431  VAL   B CA  1 
ATOM   6930 C C   . VAL   B 1 449 ? 2.43616   3.99889   -4.21805  1.000 20.09682 ? 431  VAL   B C   1 
ATOM   6931 O O   . VAL   B 1 449 ? 1.63912   3.85436   -5.14861  1.000 15.24288 ? 431  VAL   B O   1 
ATOM   6932 C CB  . VAL   B 1 449 ? 4.48716   5.46791   -4.22129  1.000 18.81496 ? 431  VAL   B CB  1 
ATOM   6933 C CG1 . VAL   B 1 449 ? 4.71015   5.05359   -5.66830  1.000 14.29343 ? 431  VAL   B CG1 1 
ATOM   6934 C CG2 . VAL   B 1 449 ? 4.97969   6.87666   -3.99064  1.000 21.27411 ? 431  VAL   B CG2 1 
ATOM   6935 N N   . LEU   B 1 450 ? 2.84048   2.99085   -3.45064  1.000 15.21798 ? 432  LEU   B N   1 
ATOM   6936 C CA  . LEU   B 1 450 ? 2.46623   1.61500   -3.71749  1.000 17.23645 ? 432  LEU   B CA  1 
ATOM   6937 C C   . LEU   B 1 450 ? 1.11612   1.31375   -3.08374  1.000 14.27197 ? 432  LEU   B C   1 
ATOM   6938 O O   . LEU   B 1 450 ? 0.87230   1.66199   -1.92599  1.000 22.90489 ? 432  LEU   B O   1 
ATOM   6939 C CB  . LEU   B 1 450 ? 3.55343   0.68388   -3.18030  1.000 17.91767 ? 432  LEU   B CB  1 
ATOM   6940 C CG  . LEU   B 1 450 ? 4.83701   0.94925   -3.97395  1.000 26.67544 ? 432  LEU   B CG  1 
ATOM   6941 C CD1 . LEU   B 1 450 ? 6.06246   0.81335   -3.12111  1.000 26.38965 ? 432  LEU   B CD1 1 
ATOM   6942 C CD2 . LEU   B 1 450 ? 4.91456   0.04409   -5.19129  1.000 12.05738 ? 432  LEU   B CD2 1 
ATOM   6943 N N   . HIS   B 1 451 ? 0.22789   0.70422   -3.85912  1.000 20.26017 ? 433  HIS   B N   1 
ATOM   6944 C CA  . HIS   B 1 451 ? -1.05800  0.24230   -3.35440  1.000 23.41492 ? 433  HIS   B CA  1 
ATOM   6945 C C   . HIS   B 1 451 ? -1.33170  -1.13793  -3.93232  1.000 17.16616 ? 433  HIS   B C   1 
ATOM   6946 O O   . HIS   B 1 451 ? -0.51652  -1.69319  -4.67977  1.000 19.66994 ? 433  HIS   B O   1 
ATOM   6947 C CB  . HIS   B 1 451 ? -2.17870  1.24319   -3.66988  1.000 17.78371 ? 433  HIS   B CB  1 
ATOM   6948 C CG  . HIS   B 1 451 ? -2.37715  1.51209   -5.13004  1.000 14.96680 ? 433  HIS   B CG  1 
ATOM   6949 N ND1 . HIS   B 1 451 ? -2.94135  0.59439   -5.98981  1.000 16.66364 ? 433  HIS   B ND1 1 
ATOM   6950 C CD2 . HIS   B 1 451 ? -2.11498  2.61286   -5.87585  1.000 16.76049 ? 433  HIS   B CD2 1 
ATOM   6951 C CE1 . HIS   B 1 451 ? -3.00945  1.11257   -7.20301  1.000 16.43260 ? 433  HIS   B CE1 1 
ATOM   6952 N NE2 . HIS   B 1 451 ? -2.51636  2.33714   -7.16035  1.000 15.18022 ? 433  HIS   B NE2 1 
ATOM   6953 N N   . VAL   B 1 452 ? -2.49201  -1.70297  -3.57523  1.000 23.07350 ? 434  VAL   B N   1 
ATOM   6954 C CA  . VAL   B 1 452 ? -2.75496  -3.11459  -3.86388  1.000 25.60905 ? 434  VAL   B CA  1 
ATOM   6955 C C   . VAL   B 1 452 ? -2.81241  -3.37291  -5.36043  1.000 24.94768 ? 434  VAL   B C   1 
ATOM   6956 O O   . VAL   B 1 452 ? -2.53490  -4.48845  -5.81627  1.000 25.95194 ? 434  VAL   B O   1 
ATOM   6957 C CB  . VAL   B 1 452 ? -4.04759  -3.57887  -3.16026  1.000 24.98876 ? 434  VAL   B CB  1 
ATOM   6958 C CG1 . VAL   B 1 452 ? -3.91500  -3.39145  -1.64251  1.000 26.99584 ? 434  VAL   B CG1 1 
ATOM   6959 C CG2 . VAL   B 1 452 ? -5.25908  -2.81192  -3.70288  1.000 28.24314 ? 434  VAL   B CG2 1 
ATOM   6960 N N   . GLY   B 1 453 ? -3.16251  -2.35809  -6.15156  1.000 21.17097 ? 435  GLY   B N   1 
ATOM   6961 C CA  . GLY   B 1 453 ? -3.11368  -2.52379  -7.58921  1.000 17.77832 ? 435  GLY   B CA  1 
ATOM   6962 C C   . GLY   B 1 453 ? -1.71373  -2.67779  -8.15363  1.000 21.21699 ? 435  GLY   B C   1 
ATOM   6963 O O   . GLY   B 1 453 ? -1.56718  -3.16260  -9.28059  1.000 28.07761 ? 435  GLY   B O   1 
ATOM   6964 N N   . TRP   B 1 454 ? -0.68360  -2.24118  -7.41537  1.000 17.73425 ? 436  TRP   B N   1 
ATOM   6965 C CA  . TRP   B 1 454 ? 0.69086   -2.54619  -7.80906  1.000 17.12918 ? 436  TRP   B CA  1 
ATOM   6966 C C   . TRP   B 1 454 ? 1.06999   -3.97519  -7.45102  1.000 20.03342 ? 436  TRP   B C   1 
ATOM   6967 O O   . TRP   B 1 454 ? 1.88457   -4.59307  -8.14438  1.000 14.27378 ? 436  TRP   B O   1 
ATOM   6968 C CB  . TRP   B 1 454 ? 1.68765   -1.61648  -7.11642  1.000 14.69752 ? 436  TRP   B CB  1 
ATOM   6969 C CG  . TRP   B 1 454 ? 1.62726   -0.17633  -7.48274  1.000 18.21553 ? 436  TRP   B CG  1 
ATOM   6970 C CD1 . TRP   B 1 454 ? 0.61766   0.70575   -7.20449  1.000 16.14077 ? 436  TRP   B CD1 1 
ATOM   6971 C CD2 . TRP   B 1 454 ? 2.65097   0.57660   -8.14727  1.000 18.64731 ? 436  TRP   B CD2 1 
ATOM   6972 N NE1 . TRP   B 1 454 ? 0.94762   1.96165   -7.66753  1.000 20.44823 ? 436  TRP   B NE1 1 
ATOM   6973 C CE2 . TRP   B 1 454 ? 2.18937   1.90729   -8.25252  1.000 20.74498 ? 436  TRP   B CE2 1 
ATOM   6974 C CE3 . TRP   B 1 454 ? 3.91163   0.25289   -8.66723  1.000 16.92962 ? 436  TRP   B CE3 1 
ATOM   6975 C CZ2 . TRP   B 1 454 ? 2.93770   2.90869   -8.86937  1.000 20.60884 ? 436  TRP   B CZ2 1 
ATOM   6976 C CZ3 . TRP   B 1 454 ? 4.65600   1.24791   -9.27942  1.000 21.06104 ? 436  TRP   B CZ3 1 
ATOM   6977 C CH2 . TRP   B 1 454 ? 4.17132   2.56445   -9.36817  1.000 17.90597 ? 436  TRP   B CH2 1 
ATOM   6978 N N   . ALA   B 1 455 ? 0.50363   -4.50278  -6.36661  1.000 19.07062 ? 437  ALA   B N   1 
ATOM   6979 C CA  . ALA   B 1 455 ? 0.92887   -5.80656  -5.87637  1.000 26.69001 ? 437  ALA   B CA  1 
ATOM   6980 C C   . ALA   B 1 455 ? 0.71151   -6.89431  -6.91447  1.000 17.94685 ? 437  ALA   B C   1 
ATOM   6981 O O   . ALA   B 1 455 ? 1.59272   -7.73484  -7.13351  1.000 18.95785 ? 437  ALA   B O   1 
ATOM   6982 C CB  . ALA   B 1 455 ? 0.18968   -6.14535  -4.58844  1.000 20.97293 ? 437  ALA   B CB  1 
ATOM   6983 N N   . THR   B 1 456 ? -0.44888  -6.89513  -7.57429  1.000 19.16173 ? 438  THR   B N   1 
ATOM   6984 C CA  . THR   B 1 456 ? -0.76385  -7.99473  -8.47750  1.000 18.63040 ? 438  THR   B CA  1 
ATOM   6985 C C   . THR   B 1 456 ? 0.22952   -8.05888  -9.63315  1.000 19.95328 ? 438  THR   B C   1 
ATOM   6986 O O   . THR   B 1 456 ? 0.59187   -9.14789  -10.09151 1.000 19.52058 ? 438  THR   B O   1 
ATOM   6987 C CB  . THR   B 1 456 ? -2.19941  -7.86734  -9.00475  1.000 31.37903 ? 438  THR   B CB  1 
ATOM   6988 O OG1 . THR   B 1 456 ? -2.43746  -8.87795  -9.99452  1.000 31.32686 ? 438  THR   B OG1 1 
ATOM   6989 C CG2 . THR   B 1 456 ? -2.42478  -6.50706  -9.63702  1.000 30.26613 ? 438  THR   B CG2 1 
ATOM   6990 N N   . PHE   B 1 457 ? 0.69925   -6.90629  -10.10853 1.000 16.05344 ? 439  PHE   B N   1 
ATOM   6991 C CA  . PHE   B 1 457 ? 1.61867   -6.93807  -11.24057 1.000 13.46254 ? 439  PHE   B CA  1 
ATOM   6992 C C   . PHE   B 1 457 ? 3.03325   -7.30548  -10.81348 1.000 15.63278 ? 439  PHE   B C   1 
ATOM   6993 O O   . PHE   B 1 457 ? 3.74351   -7.99450  -11.55839 1.000 15.30588 ? 439  PHE   B O   1 
ATOM   6994 C CB  . PHE   B 1 457 ? 1.59017   -5.60176  -11.97783 1.000 14.46372 ? 439  PHE   B CB  1 
ATOM   6995 C CG  . PHE   B 1 457 ? 0.29831   -5.35832  -12.68660 1.000 16.40276 ? 439  PHE   B CG  1 
ATOM   6996 C CD1 . PHE   B 1 457 ? -0.00135  -6.04815  -13.85177 1.000 22.32853 ? 439  PHE   B CD1 1 
ATOM   6997 C CD2 . PHE   B 1 457 ? -0.63841  -4.48616  -12.16602 1.000 17.66641 ? 439  PHE   B CD2 1 
ATOM   6998 C CE1 . PHE   B 1 457 ? -1.21172  -5.85094  -14.50563 1.000 28.11614 ? 439  PHE   B CE1 1 
ATOM   6999 C CE2 . PHE   B 1 457 ? -1.85024  -4.27720  -12.81240 1.000 24.44586 ? 439  PHE   B CE2 1 
ATOM   7000 C CZ  . PHE   B 1 457 ? -2.13365  -4.96356  -13.98751 1.000 28.36610 ? 439  PHE   B CZ  1 
ATOM   7001 N N   . LEU   B 1 458 ? 3.45888   -6.86404  -9.62809  1.000 10.43703 ? 440  LEU   B N   1 
ATOM   7002 C CA  . LEU   B 1 458 ? 4.73444   -7.32957  -9.10265  1.000 16.26795 ? 440  LEU   B CA  1 
ATOM   7003 C C   . LEU   B 1 458 ? 4.74731   -8.84850  -8.99303  1.000 14.58389 ? 440  LEU   B C   1 
ATOM   7004 O O   . LEU   B 1 458 ? 5.69293   -9.50622  -9.43833  1.000 14.08989 ? 440  LEU   B O   1 
ATOM   7005 C CB  . LEU   B 1 458 ? 5.00974   -6.69964  -7.74020  1.000 14.37409 ? 440  LEU   B CB  1 
ATOM   7006 C CG  . LEU   B 1 458 ? 6.17962   -7.30383  -6.96345  1.000 11.61598 ? 440  LEU   B CG  1 
ATOM   7007 C CD1 . LEU   B 1 458 ? 7.48380   -7.09316  -7.72673  1.000 9.94299  ? 440  LEU   B CD1 1 
ATOM   7008 C CD2 . LEU   B 1 458 ? 6.25849   -6.66108  -5.57776  1.000 23.06457 ? 440  LEU   B CD2 1 
ATOM   7009 N N   . VAL   B 1 459 ? 3.69882   -9.42483  -8.39924  1.000 13.57444 ? 441  VAL   B N   1 
ATOM   7010 C CA  . VAL   B 1 459 ? 3.67042   -10.87112 -8.19153  1.000 13.41120 ? 441  VAL   B CA  1 
ATOM   7011 C C   . VAL   B 1 459 ? 3.72482   -11.60400 -9.52440  1.000 14.35690 ? 441  VAL   B C   1 
ATOM   7012 O O   . VAL   B 1 459 ? 4.44687   -12.59772 -9.67737  1.000 17.26490 ? 441  VAL   B O   1 
ATOM   7013 C CB  . VAL   B 1 459 ? 2.42736   -11.26418 -7.37012  1.000 18.54969 ? 441  VAL   B CB  1 
ATOM   7014 C CG1 . VAL   B 1 459 ? 2.20354   -12.76994 -7.41650  1.000 25.27135 ? 441  VAL   B CG1 1 
ATOM   7015 C CG2 . VAL   B 1 459 ? 2.59070   -10.80232 -5.93458  1.000 20.21344 ? 441  VAL   B CG2 1 
ATOM   7016 N N   . GLN   B 1 460 ? 2.97197   -11.12101 -10.51154 1.000 17.99908 ? 442  GLN   B N   1 
ATOM   7017 C CA  . GLN   B 1 460 ? 3.00387   -11.73014 -11.83520 1.000 16.68113 ? 442  GLN   B CA  1 
ATOM   7018 C C   . GLN   B 1 460 ? 4.37736   -11.57839 -12.49030 1.000 18.69513 ? 442  GLN   B C   1 
ATOM   7019 O O   . GLN   B 1 460 ? 4.90971   -12.53385 -13.07246 1.000 14.13718 ? 442  GLN   B O   1 
ATOM   7020 C CB  . GLN   B 1 460 ? 1.90945   -11.11230 -12.70261 1.000 18.06368 ? 442  GLN   B CB  1 
ATOM   7021 C CG  . GLN   B 1 460 ? 1.83752   -11.68859 -14.09714 1.000 22.46031 ? 442  GLN   B CG  1 
ATOM   7022 C CD  . GLN   B 1 460 ? 1.01780   -10.83401 -15.04174 1.000 31.25867 ? 442  GLN   B CD  1 
ATOM   7023 O OE1 . GLN   B 1 460 ? 1.04207   -9.60059  -14.97023 1.000 29.63278 ? 442  GLN   B OE1 1 
ATOM   7024 N NE2 . GLN   B 1 460 ? 0.27217   -11.48703 -15.92834 1.000 30.14268 ? 442  GLN   B NE2 1 
ATOM   7025 N N   . SER   B 1 461 ? 4.97787   -10.39088 -12.39470 1.000 15.27750 ? 443  SER   B N   1 
ATOM   7026 C CA  . SER   B 1 461 ? 6.29618   -10.19165 -12.98947 1.000 13.19603 ? 443  SER   B CA  1 
ATOM   7027 C C   . SER   B 1 461 ? 7.34251   -11.09157 -12.33262 1.000 16.70235 ? 443  SER   B C   1 
ATOM   7028 O O   . SER   B 1 461 ? 8.18960   -11.66960 -13.02325 1.000 16.35506 ? 443  SER   B O   1 
ATOM   7029 C CB  . SER   B 1 461 ? 6.69556   -8.71908  -12.89247 1.000 12.46614 ? 443  SER   B CB  1 
ATOM   7030 O OG  . SER   B 1 461 ? 5.90073   -7.92223  -13.76330 1.000 16.24299 ? 443  SER   B OG  1 
ATOM   7031 N N   . LEU   B 1 462 ? 7.29558   -11.22693 -11.00125 1.000 15.73101 ? 444  LEU   B N   1 
ATOM   7032 C CA  . LEU   B 1 462 ? 8.20494   -12.14658 -10.31163 1.000 15.22214 ? 444  LEU   B CA  1 
ATOM   7033 C C   . LEU   B 1 462 ? 8.09634   -13.55966 -10.86648 1.000 18.33904 ? 444  LEU   B C   1 
ATOM   7034 O O   . LEU   B 1 462 ? 9.11519   -14.23919 -11.06986 1.000 17.39595 ? 444  LEU   B O   1 
ATOM   7035 C CB  . LEU   B 1 462 ? 7.91158   -12.16714 -8.81386  1.000 13.28400 ? 444  LEU   B CB  1 
ATOM   7036 C CG  . LEU   B 1 462 ? 8.14947   -10.90319 -7.99563  1.000 14.68508 ? 444  LEU   B CG  1 
ATOM   7037 C CD1 . LEU   B 1 462 ? 7.66021   -11.11907 -6.58016  1.000 17.41135 ? 444  LEU   B CD1 1 
ATOM   7038 C CD2 . LEU   B 1 462 ? 9.62147   -10.54928 -8.01224  1.000 13.48463 ? 444  LEU   B CD2 1 
ATOM   7039 N N   . GLY   B 1 463 ? 6.87047   -14.01964 -11.11508 1.000 15.05848 ? 445  GLY   B N   1 
ATOM   7040 C CA  . GLY   B 1 463 ? 6.63645   -15.39139 -11.55432 1.000 19.69183 ? 445  GLY   B CA  1 
ATOM   7041 C C   . GLY   B 1 463 ? 7.10981   -15.69489 -12.95874 1.000 17.33602 ? 445  GLY   B C   1 
ATOM   7042 O O   . GLY   B 1 463 ? 7.14176   -16.87161 -13.34332 1.000 20.02293 ? 445  GLY   B O   1 
ATOM   7043 N N   . ARG   B 1 464 ? 7.45652   -14.67189 -13.73931 1.000 16.40203 ? 446  ARG   B N   1 
ATOM   7044 C CA  . ARG   B 1 464 ? 8.04350   -14.90737 -15.05063 1.000 20.66712 ? 446  ARG   B CA  1 
ATOM   7045 C C   . ARG   B 1 464 ? 9.46039   -15.45191 -14.96010 1.000 22.20879 ? 446  ARG   B C   1 
ATOM   7046 O O   . ARG   B 1 464 ? 10.00459  -15.88064 -15.98414 1.000 17.19265 ? 446  ARG   B O   1 
ATOM   7047 C CB  . ARG   B 1 464 ? 8.05834   -13.61487 -15.86832 1.000 22.80729 ? 446  ARG   B CB  1 
ATOM   7048 C CG  . ARG   B 1 464 ? 6.68839   -12.98466 -16.04621 1.000 18.04135 ? 446  ARG   B CG  1 
ATOM   7049 C CD  . ARG   B 1 464 ? 5.77035   -13.81747 -16.93792 1.000 20.23931 ? 446  ARG   B CD  1 
ATOM   7050 N NE  . ARG   B 1 464 ? 4.56562   -13.06588 -17.27749 1.000 18.50175 ? 446  ARG   B NE  1 
ATOM   7051 C CZ  . ARG   B 1 464 ? 3.45163   -13.59230 -17.76994 1.000 27.09004 ? 446  ARG   B CZ  1 
ATOM   7052 N NH1 . ARG   B 1 464 ? 3.32955   -14.89658 -17.97809 1.000 20.09087 ? 446  ARG   B NH1 1 
ATOM   7053 N NH2 . ARG   B 1 464 ? 2.43111   -12.78902 -18.05829 1.000 19.40005 ? 446  ARG   B NH2 1 
ATOM   7054 N N   . PHE   B 1 465 ? 10.07370  -15.42460 -13.77924 1.000 18.80777 ? 447  PHE   B N   1 
ATOM   7055 C CA  . PHE   B 1 465 ? 11.42903  -15.92350 -13.58254 1.000 16.50461 ? 447  PHE   B CA  1 
ATOM   7056 C C   . PHE   B 1 465 ? 11.39079  -17.16461 -12.70226 1.000 15.33977 ? 447  PHE   B C   1 
ATOM   7057 O O   . PHE   B 1 465 ? 10.84070  -17.13003 -11.59597 1.000 15.56576 ? 447  PHE   B O   1 
ATOM   7058 C CB  . PHE   B 1 465 ? 12.33137  -14.87113 -12.93193 1.000 13.75661 ? 447  PHE   B CB  1 
ATOM   7059 C CG  . PHE   B 1 465 ? 12.46137  -13.60514 -13.70997 1.000 11.57417 ? 447  PHE   B CG  1 
ATOM   7060 C CD1 . PHE   B 1 465 ? 11.48419  -12.62259 -13.62978 1.000 12.51118 ? 447  PHE   B CD1 1 
ATOM   7061 C CD2 . PHE   B 1 465 ? 13.57247  -13.38341 -14.51121 1.000 13.99347 ? 447  PHE   B CD2 1 
ATOM   7062 C CE1 . PHE   B 1 465 ? 11.61715  -11.44483 -14.33923 1.000 13.35151 ? 447  PHE   B CE1 1 
ATOM   7063 C CE2 . PHE   B 1 465 ? 13.70981  -12.20695 -15.22287 1.000 16.80081 ? 447  PHE   B CE2 1 
ATOM   7064 C CZ  . PHE   B 1 465 ? 12.72388  -11.23406 -15.13670 1.000 14.73815 ? 447  PHE   B CZ  1 
ATOM   7065 N N   . GLU   B 1 466 ? 12.00208  -18.24707 -13.18170 1.000 22.06641 ? 448  GLU   B N   1 
ATOM   7066 C CA  . GLU   B 1 466 ? 12.08034  -19.47049 -12.39515 1.000 26.51294 ? 448  GLU   B CA  1 
ATOM   7067 C C   . GLU   B 1 466 ? 12.82684  -19.21911 -11.08460 1.000 22.22650 ? 448  GLU   B C   1 
ATOM   7068 O O   . GLU   B 1 466 ? 13.72823  -18.37753 -11.00450 1.000 18.75143 ? 448  GLU   B O   1 
ATOM   7069 C CB  . GLU   B 1 466 ? 12.77802  -20.56710 -13.20753 1.000 29.19355 ? 448  GLU   B CB  1 
ATOM   7070 C CG  . GLU   B 1 466 ? 11.88755  -21.26567 -14.23866 1.000 35.10030 ? 448  GLU   B CG  1 
ATOM   7071 C CD  . GLU   B 1 466 ? 10.82484  -22.16678 -13.62036 1.000 40.74330 ? 448  GLU   B CD  1 
ATOM   7072 O OE1 . GLU   B 1 466 ? 10.77567  -22.28630 -12.37613 1.000 56.04123 ? 448  GLU   B OE1 1 
ATOM   7073 O OE2 . GLU   B 1 466 ? 10.03329  -22.75978 -14.38538 1.000 51.31759 ? 448  GLU   B OE2 1 
ATOM   7074 N N   . GLY   B 1 467 ? 12.43280  -19.95062 -10.03939 1.000 22.15695 ? 449  GLY   B N   1 
ATOM   7075 C CA  . GLY   B 1 467 ? 13.09078  -19.78547 -8.74832  1.000 21.49273 ? 449  GLY   B CA  1 
ATOM   7076 C C   . GLY   B 1 467 ? 14.59419  -19.99811 -8.81518  1.000 23.90229 ? 449  GLY   B C   1 
ATOM   7077 O O   . GLY   B 1 467 ? 15.36083  -19.29993 -8.14676  1.000 30.14300 ? 449  GLY   B O   1 
ATOM   7078 N N   . GLN   B 1 468 ? 15.03896  -20.96513 -9.62226  1.000 25.85219 ? 450  GLN   B N   1 
ATOM   7079 C CA  . GLN   B 1 468 ? 16.47347  -21.19146 -9.78270  1.000 30.72963 ? 450  GLN   B CA  1 
ATOM   7080 C C   . GLN   B 1 468 ? 17.16569  -19.96126 -10.35267 1.000 33.68297 ? 450  GLN   B C   1 
ATOM   7081 O O   . GLN   B 1 468 ? 18.33327  -19.69444 -10.03526 1.000 27.11911 ? 450  GLN   B O   1 
ATOM   7082 C CB  . GLN   B 1 468 ? 16.71998  -22.40351 -10.68723 1.000 29.40530 ? 450  GLN   B CB  1 
ATOM   7083 C CG  . GLN   B 1 468 ? 15.65843  -23.49287 -10.55846 1.000 46.47199 ? 450  GLN   B CG  1 
ATOM   7084 C CD  . GLN   B 1 468 ? 14.42638  -23.22921 -11.42016 1.000 58.22774 ? 450  GLN   B CD  1 
ATOM   7085 O OE1 . GLN   B 1 468 ? 14.52932  -23.07239 -12.64132 1.000 65.30462 ? 450  GLN   B OE1 1 
ATOM   7086 N NE2 . GLN   B 1 468 ? 13.25621  -23.15951 -10.78111 1.000 31.65899 ? 450  GLN   B NE2 1 
ATOM   7087 N N   . VAL   B 1 469 ? 16.46424  -19.20533 -11.19657 1.000 19.29715 ? 451  VAL   B N   1 
ATOM   7088 C CA  . VAL   B 1 469 ? 17.00393  -17.94957 -11.69464 1.000 19.08725 ? 451  VAL   B CA  1 
ATOM   7089 C C   . VAL   B 1 469 ? 16.95087  -16.88631 -10.60456 1.000 21.24370 ? 451  VAL   B C   1 
ATOM   7090 O O   . VAL   B 1 469 ? 17.94172  -16.19627 -10.33652 1.000 23.03843 ? 451  VAL   B O   1 
ATOM   7091 C CB  . VAL   B 1 469 ? 16.24260  -17.50570 -12.95674 1.000 23.31285 ? 451  VAL   B CB  1 
ATOM   7092 C CG1 . VAL   B 1 469 ? 16.77081  -16.16217 -13.44950 1.000 21.47261 ? 451  VAL   B CG1 1 
ATOM   7093 C CG2 . VAL   B 1 469 ? 16.34609  -18.56738 -14.04920 1.000 24.20574 ? 451  VAL   B CG2 1 
ATOM   7094 N N   . ARG   B 1 470 ? 15.79389  -16.74502 -9.95237  1.000 19.40572 ? 452  ARG   B N   1 
ATOM   7095 C CA  . ARG   B 1 470 ? 15.63742  -15.70250 -8.94672  1.000 23.43246 ? 452  ARG   B CA  1 
ATOM   7096 C C   . ARG   B 1 470 ? 16.62415  -15.89063 -7.80132  1.000 26.27963 ? 452  ARG   B C   1 
ATOM   7097 O O   . ARG   B 1 470 ? 17.14055  -14.90999 -7.24937  1.000 21.32093 ? 452  ARG   B O   1 
ATOM   7098 C CB  . ARG   B 1 470 ? 14.19173  -15.68623 -8.43482  1.000 19.19825 ? 452  ARG   B CB  1 
ATOM   7099 C CG  . ARG   B 1 470 ? 13.18694  -15.28713 -9.52838  1.000 16.96851 ? 452  ARG   B CG  1 
ATOM   7100 C CD  . ARG   B 1 470 ? 11.74252  -15.10578 -9.00323  1.000 13.46277 ? 452  ARG   B CD  1 
ATOM   7101 N NE  . ARG   B 1 470 ? 11.04317  -16.37929 -8.88830  1.000 19.23243 ? 452  ARG   B NE  1 
ATOM   7102 C CZ  . ARG   B 1 470 ? 10.72527  -16.95226 -7.73593  1.000 19.95348 ? 452  ARG   B CZ  1 
ATOM   7103 N NH1 . ARG   B 1 470 ? 10.99739  -16.37141 -6.57743  1.000 21.91375 ? 452  ARG   B NH1 1 
ATOM   7104 N NH2 . ARG   B 1 470 ? 10.11565  -18.13366 -7.74516  1.000 20.69338 ? 452  ARG   B NH2 1 
ATOM   7105 N N   . GLN   B 1 471 ? 16.92194  -17.14546 -7.45030  1.000 27.31593 ? 453  GLN   B N   1 
ATOM   7106 C CA  . GLN   B 1 471 ? 17.81956  -17.42219 -6.33360  1.000 22.81844 ? 453  GLN   B CA  1 
ATOM   7107 C C   . GLN   B 1 471 ? 19.28256  -17.12134 -6.64305  1.000 24.77309 ? 453  GLN   B C   1 
ATOM   7108 O O   . GLN   B 1 471 ? 20.09601  -17.08408 -5.71172  1.000 26.47649 ? 453  GLN   B O   1 
ATOM   7109 C CB  . GLN   B 1 471 ? 17.63286  -18.87398 -5.88147  1.000 26.41253 ? 453  GLN   B CB  1 
ATOM   7110 C CG  . GLN   B 1 471 ? 16.35107  -19.03241 -5.07347  1.000 21.93077 ? 453  GLN   B CG  1 
ATOM   7111 C CD  . GLN   B 1 471 ? 15.71269  -20.41234 -5.15954  1.000 40.41281 ? 453  GLN   B CD  1 
ATOM   7112 O OE1 . GLN   B 1 471 ? 16.34220  -21.38561 -5.57963  1.000 32.28465 ? 453  GLN   B OE1 1 
ATOM   7113 N NE2 . GLN   B 1 471 ? 14.44023  -20.49448 -4.77076  1.000 32.41683 ? 453  GLN   B NE2 1 
ATOM   7114 N N   . LYS   B 1 472 ? 19.63237  -16.87430 -7.90283  1.000 21.10183 ? 454  LYS   B N   1 
ATOM   7115 C CA  . LYS   B 1 472 ? 20.96957  -16.42944 -8.26770  1.000 20.08601 ? 454  LYS   B CA  1 
ATOM   7116 C C   . LYS   B 1 472 ? 21.11396  -14.91350 -8.27429  1.000 27.27138 ? 454  LYS   B C   1 
ATOM   7117 O O   . LYS   B 1 472 ? 22.16446  -14.40994 -8.68661  1.000 29.91606 ? 454  LYS   B O   1 
ATOM   7118 C CB  . LYS   B 1 472 ? 21.35633  -16.98038 -9.64221  1.000 22.59970 ? 454  LYS   B CB  1 
ATOM   7119 C CG  . LYS   B 1 472 ? 21.34172  -18.49617 -9.73562  1.000 31.95192 ? 454  LYS   B CG  1 
ATOM   7120 C CD  . LYS   B 1 472 ? 22.12910  -18.96299 -10.94145 1.000 34.97280 ? 454  LYS   B CD  1 
ATOM   7121 C CE  . LYS   B 1 472 ? 22.85571  -20.27477 -10.66307 1.000 45.68909 ? 454  LYS   B CE  1 
ATOM   7122 N NZ  . LYS   B 1 472 ? 22.31238  -21.39902 -11.47197 1.000 53.27686 ? 454  LYS   B NZ  1 
ATOM   7123 N N   . VAL   B 1 473 ? 20.09593  -14.17270 -7.83154  1.000 18.78208 ? 455  VAL   B N   1 
ATOM   7124 C CA  . VAL   B 1 473 ? 20.16880  -12.71955 -7.89792  1.000 24.49980 ? 455  VAL   B CA  1 
ATOM   7125 C C   . VAL   B 1 473 ? 21.19312  -12.21786 -6.88617  1.000 23.93563 ? 455  VAL   B C   1 
ATOM   7126 O O   . VAL   B 1 473 ? 21.31126  -12.73883 -5.76845  1.000 29.44423 ? 455  VAL   B O   1 
ATOM   7127 C CB  . VAL   B 1 473 ? 18.77981  -12.09101 -7.67084  1.000 23.35057 ? 455  VAL   B CB  1 
ATOM   7128 C CG1 . VAL   B 1 473 ? 18.40355  -12.06670 -6.18982  1.000 21.87717 ? 455  VAL   B CG1 1 
ATOM   7129 C CG2 . VAL   B 1 473 ? 18.70870  -10.69314 -8.28897  1.000 17.12825 ? 455  VAL   B CG2 1 
ATOM   7130 N N   . ARG   B 1 474 ? 21.97799  -11.23365 -7.28524  1.000 23.73561 ? 456  ARG   B N   1 
ATOM   7131 C CA  . ARG   B 1 474 ? 22.94359  -10.63507 -6.37178  1.000 36.50072 ? 456  ARG   B CA  1 
ATOM   7132 C C   . ARG   B 1 474 ? 22.56247  -9.17255  -6.26005  1.000 30.56339 ? 456  ARG   B C   1 
ATOM   7133 O O   . ARG   B 1 474 ? 22.88363  -8.36824  -7.14176  1.000 43.84365 ? 456  ARG   B O   1 
ATOM   7134 C CB  . ARG   B 1 474 ? 24.37326  -10.82404 -6.85438  1.000 40.39435 ? 456  ARG   B CB  1 
ATOM   7135 C CG  . ARG   B 1 474 ? 24.78810  -12.27127 -6.93571  1.000 32.16760 ? 456  ARG   B CG  1 
ATOM   7136 C CD  . ARG   B 1 474 ? 26.27094  -12.37605 -7.23670  1.000 26.59816 ? 456  ARG   B CD  1 
ATOM   7137 N NE  . ARG   B 1 474 ? 26.54433  -12.71320 -8.62823  1.000 31.96255 ? 456  ARG   B NE  1 
ATOM   7138 C CZ  . ARG   B 1 474 ? 27.03427  -11.85976 -9.52065  1.000 38.07393 ? 456  ARG   B CZ  1 
ATOM   7139 N NH1 . ARG   B 1 474 ? 27.22228  -10.58195 -9.22494  1.000 30.80734 ? 456  ARG   B NH1 1 
ATOM   7140 N NH2 . ARG   B 1 474 ? 27.33764  -12.29724 -10.74168 1.000 26.58481 ? 456  ARG   B NH2 1 
ATOM   7141 N N   . ILE   B 1 475 ? 21.83337  -8.83753  -5.20305  1.000 28.48635 ? 457  ILE   B N   1 
ATOM   7142 C CA  . ILE   B 1 475 ? 21.31771  -7.48353  -5.06684  1.000 27.09628 ? 457  ILE   B CA  1 
ATOM   7143 C C   . ILE   B 1 475 ? 21.30931  -7.10210  -3.59635  1.000 21.53456 ? 457  ILE   B C   1 
ATOM   7144 O O   . ILE   B 1 475 ? 20.99500  -7.91619  -2.72509  1.000 26.17503 ? 457  ILE   B O   1 
ATOM   7145 C CB  . ILE   B 1 475 ? 19.91957  -7.34320  -5.71037  1.000 23.27591 ? 457  ILE   B CB  1 
ATOM   7146 C CG1 . ILE   B 1 475 ? 19.59346  -5.86818  -5.94391  1.000 25.29596 ? 457  ILE   B CG1 1 
ATOM   7147 C CG2 . ILE   B 1 475 ? 18.84264  -7.99401  -4.84917  1.000 22.41571 ? 457  ILE   B CG2 1 
ATOM   7148 C CD1 . ILE   B 1 475 ? 18.29249  -5.63718  -6.66289  1.000 29.07770 ? 457  ILE   B CD1 1 
ATOM   7149 N N   . THR   B 1 476 ? 21.68364  -5.85521  -3.33362  1.000 23.11600 ? 552  THR   B N   1 
ATOM   7150 C CA  . THR   B 1 476 ? 21.55960  -5.22924  -2.02654  1.000 27.03686 ? 552  THR   B CA  1 
ATOM   7151 C C   . THR   B 1 476 ? 20.51949  -4.12754  -2.15400  1.000 23.69797 ? 552  THR   B C   1 
ATOM   7152 O O   . THR   B 1 476 ? 20.69010  -3.20821  -2.96119  1.000 24.23487 ? 552  THR   B O   1 
ATOM   7153 C CB  . THR   B 1 476 ? 22.89395  -4.64682  -1.56418  1.000 27.47330 ? 552  THR   B CB  1 
ATOM   7154 O OG1 . THR   B 1 476 ? 23.84463  -5.70491  -1.41060  1.000 32.98024 ? 552  THR   B OG1 1 
ATOM   7155 C CG2 . THR   B 1 476 ? 22.72158  -3.92489  -0.23607  1.000 30.48715 ? 552  THR   B CG2 1 
ATOM   7156 N N   . PHE   B 1 477 ? 19.44319  -4.23227  -1.38312  1.000 16.97271 ? 553  PHE   B N   1 
ATOM   7157 C CA  . PHE   B 1 477 ? 18.36511  -3.25804  -1.46673  1.000 21.74729 ? 553  PHE   B CA  1 
ATOM   7158 C C   . PHE   B 1 477 ? 18.68395  -2.01939  -0.64312  1.000 24.31431 ? 553  PHE   B C   1 
ATOM   7159 O O   . PHE   B 1 477 ? 19.35132  -2.08865  0.39405   1.000 23.13259 ? 553  PHE   B O   1 
ATOM   7160 C CB  . PHE   B 1 477 ? 17.05683  -3.86251  -0.97436  1.000 15.93646 ? 553  PHE   B CB  1 
ATOM   7161 C CG  . PHE   B 1 477 ? 16.48583  -4.89655  -1.89050  1.000 12.43236 ? 553  PHE   B CG  1 
ATOM   7162 C CD1 . PHE   B 1 477 ? 16.35012  -4.63892  -3.24790  1.000 17.19779 ? 553  PHE   B CD1 1 
ATOM   7163 C CD2 . PHE   B 1 477 ? 16.05983  -6.12165  -1.38949  1.000 14.60006 ? 553  PHE   B CD2 1 
ATOM   7164 C CE1 . PHE   B 1 477 ? 15.80081  -5.58860  -4.09437  1.000 16.54647 ? 553  PHE   B CE1 1 
ATOM   7165 C CE2 . PHE   B 1 477 ? 15.51395  -7.06738  -2.22366  1.000 13.29656 ? 553  PHE   B CE2 1 
ATOM   7166 C CZ  . PHE   B 1 477 ? 15.38491  -6.80254  -3.58350  1.000 14.90449 ? 553  PHE   B CZ  1 
ATOM   7167 N N   . GLN   B 1 478 ? 18.18838  -0.87672  -1.11187  1.000 17.63002 ? 554  GLN   B N   1 
ATOM   7168 C CA  . GLN   B 1 478 ? 18.26837  0.35681   -0.34349  1.000 16.96319 ? 554  GLN   B CA  1 
ATOM   7169 C C   . GLN   B 1 478 ? 16.98617  0.67993   0.39926   1.000 19.93784 ? 554  GLN   B C   1 
ATOM   7170 O O   . GLN   B 1 478 ? 17.03964  1.35583   1.43192   1.000 19.08424 ? 554  GLN   B O   1 
ATOM   7171 C CB  . GLN   B 1 478 ? 18.63101  1.53535   -1.25835  1.000 21.40908 ? 554  GLN   B CB  1 
ATOM   7172 C CG  . GLN   B 1 478 ? 20.00026  1.38797   -1.90887  1.000 30.37331 ? 554  GLN   B CG  1 
ATOM   7173 C CD  . GLN   B 1 478 ? 21.09397  1.23888   -0.87231  1.000 31.41879 ? 554  GLN   B CD  1 
ATOM   7174 O OE1 . GLN   B 1 478 ? 21.05770  1.89311   0.17313   1.000 32.82918 ? 554  GLN   B OE1 1 
ATOM   7175 N NE2 . GLN   B 1 478 ? 22.06591  0.37334   -1.14514  1.000 27.74105 ? 554  GLN   B NE2 1 
ATOM   7176 N N   . SER   B 1 479 ? 15.83838  0.20910   -0.08267  1.000 17.79172 ? 555  SER   B N   1 
ATOM   7177 C CA  . SER   B 1 479 ? 14.56986  0.53406   0.55487   1.000 14.60071 ? 555  SER   B CA  1 
ATOM   7178 C C   . SER   B 1 479 ? 14.23502  -0.45018  1.66301   1.000 18.97788 ? 555  SER   B C   1 
ATOM   7179 O O   . SER   B 1 479 ? 14.58081  -1.63277  1.60799   1.000 18.68257 ? 555  SER   B O   1 
ATOM   7180 C CB  . SER   B 1 479 ? 13.41752  0.54226   -0.44410  1.000 18.11506 ? 555  SER   B CB  1 
ATOM   7181 O OG  . SER   B 1 479 ? 13.03856  -0.78011  -0.79469  1.000 17.09468 ? 555  SER   B OG  1 
ATOM   7182 N N   . GLU   B 1 480 ? 13.47518  0.04162   2.63609   1.000 20.89874 ? 556  GLU   B N   1 
ATOM   7183 C CA  . GLU   B 1 480 ? 13.14058  -0.77247  3.79295   1.000 22.58577 ? 556  GLU   B CA  1 
ATOM   7184 C C   . GLU   B 1 480 ? 12.16467  -1.87612  3.40542   1.000 19.34924 ? 556  GLU   B C   1 
ATOM   7185 O O   . GLU   B 1 480 ? 12.26963  -3.01080  3.88795   1.000 17.16347 ? 556  GLU   B O   1 
ATOM   7186 C CB  . GLU   B 1 480 ? 12.55406  0.13000   4.87713   1.000 21.29271 ? 556  GLU   B CB  1 
ATOM   7187 C CG  . GLU   B 1 480 ? 13.62022  0.92524   5.64502   1.000 31.49471 ? 556  GLU   B CG  1 
ATOM   7188 C CD  . GLU   B 1 480 ? 14.58053  0.08859   6.48394   1.000 49.05365 ? 556  GLU   B CD  1 
ATOM   7189 O OE1 . GLU   B 1 480 ? 14.59150  -1.15914  6.38512   1.000 51.48173 ? 556  GLU   B OE1 1 
ATOM   7190 O OE2 . GLU   B 1 480 ? 15.38307  0.70477   7.21599   1.000 50.63122 ? 556  GLU   B OE2 1 
ATOM   7191 N N   . LYS   B 1 481 ? 11.22202  -1.56239  2.51333   1.000 17.21259 ? 557  LYS   B N   1 
ATOM   7192 C CA  . LYS   B 1 481 ? 10.21363  -2.53327  2.09663   1.000 17.62046 ? 557  LYS   B CA  1 
ATOM   7193 C C   . LYS   B 1 481 ? 10.84181  -3.69858  1.34732   1.000 19.65472 ? 557  LYS   B C   1 
ATOM   7194 O O   . LYS   B 1 481 ? 10.49010  -4.86276  1.58235   1.000 17.23285 ? 557  LYS   B O   1 
ATOM   7195 C CB  . LYS   B 1 481 ? 9.16337   -1.84492  1.22081   1.000 19.84795 ? 557  LYS   B CB  1 
ATOM   7196 C CG  . LYS   B 1 481 ? 7.90589   -1.43020  1.95615   1.000 25.59325 ? 557  LYS   B CG  1 
ATOM   7197 C CD  . LYS   B 1 481 ? 6.93634   -0.67694  1.04376   1.000 20.62464 ? 557  LYS   B CD  1 
ATOM   7198 C CE  . LYS   B 1 481 ? 5.98022   0.16742   1.87327   1.000 19.58277 ? 557  LYS   B CE  1 
ATOM   7199 N NZ  . LYS   B 1 481 ? 4.87672   0.77582   1.06319   1.000 20.05785 ? 557  LYS   B NZ  1 
ATOM   7200 N N   . MET   B 1 482 ? 11.76454  -3.40642  0.42866   1.000 14.90460 ? 558  MET   B N   1 
ATOM   7201 C CA  . MET   B 1 482 ? 12.37724  -4.47095  -0.36226  1.000 17.75908 ? 558  MET   B CA  1 
ATOM   7202 C C   . MET   B 1 482 ? 13.26970  -5.34904  0.51284   1.000 16.93355 ? 558  MET   B C   1 
ATOM   7203 O O   . MET   B 1 482 ? 13.25608  -6.58177  0.38787   1.000 12.61094 ? 558  MET   B O   1 
ATOM   7204 C CB  . MET   B 1 482 ? 13.16783  -3.84262  -1.51146  1.000 16.87519 ? 558  MET   B CB  1 
ATOM   7205 C CG  . MET   B 1 482 ? 12.33878  -3.48547  -2.77735  1.000 12.86874 ? 558  MET   B CG  1 
ATOM   7206 S SD  . MET   B 1 482 ? 10.87364  -4.43546  -3.27206  1.000 14.64699 ? 558  MET   B SD  1 
ATOM   7207 C CE  . MET   B 1 482 ? 11.64062  -5.39248  -4.56799  1.000 15.69592 ? 558  MET   B CE  1 
ATOM   7208 N N   . LYS   B 1 483 ? 14.06044  -4.73237  1.39738   1.000 14.42293 ? 559  LYS   B N   1 
ATOM   7209 C CA  . LYS   B 1 483 ? 14.80236  -5.50589  2.39217   1.000 23.35914 ? 559  LYS   B CA  1 
ATOM   7210 C C   . LYS   B 1 483 ? 13.86115  -6.37303  3.21650   1.000 18.84061 ? 559  LYS   B C   1 
ATOM   7211 O O   . LYS   B 1 483 ? 14.13141  -7.55790  3.45237   1.000 20.30361 ? 559  LYS   B O   1 
ATOM   7212 C CB  . LYS   B 1 483 ? 15.61532  -4.56808  3.29341   1.000 18.70786 ? 559  LYS   B CB  1 
ATOM   7213 C CG  . LYS   B 1 483 ? 16.60328  -3.70193  2.52298   1.000 28.36194 ? 559  LYS   B CG  1 
ATOM   7214 C CD  . LYS   B 1 483 ? 17.56934  -2.95494  3.43354   1.000 37.05172 ? 559  LYS   B CD  1 
ATOM   7215 C CE  . LYS   B 1 483 ? 16.83948  -1.99002  4.35117   1.000 36.98384 ? 559  LYS   B CE  1 
ATOM   7216 N NZ  . LYS   B 1 483 ? 17.73303  -0.89108  4.83253   1.000 43.46054 ? 559  LYS   B NZ  1 
ATOM   7217 N N   . GLY   B 1 484 ? 12.73169  -5.80256  3.63470   1.000 20.19743 ? 560  GLY   B N   1 
ATOM   7218 C CA  . GLY   B 1 484 ? 11.78759  -6.55092  4.44670   1.000 18.58108 ? 560  GLY   B CA  1 
ATOM   7219 C C   . GLY   B 1 484 ? 11.31212  -7.83469  3.79461   1.000 26.44014 ? 560  GLY   B C   1 
ATOM   7220 O O   . GLY   B 1 484 ? 11.07510  -8.83248  4.47749   1.000 25.04834 ? 560  GLY   B O   1 
ATOM   7221 N N   . MET   B 1 485 ? 11.16160  -7.83709  2.46441   1.000 16.91637 ? 561  MET   B N   1 
ATOM   7222 C CA  . MET   B 1 485 ? 10.55869  -8.98903  1.79943   1.000 20.01063 ? 561  MET   B CA  1 
ATOM   7223 C C   . MET   B 1 485 ? 11.53110  -9.71487  0.87718   1.000 18.73235 ? 561  MET   B C   1 
ATOM   7224 O O   . MET   B 1 485 ? 11.09619  -10.51796 0.04671   1.000 19.52122 ? 561  MET   B O   1 
ATOM   7225 C CB  . MET   B 1 485 ? 9.29927   -8.59055  1.02032   1.000 24.83686 ? 561  MET   B CB  1 
ATOM   7226 C CG  . MET   B 1 485 ? 9.51870   -7.71950  -0.19988  1.000 24.94959 ? 561  MET   B CG  1 
ATOM   7227 S SD  . MET   B 1 485 ? 7.93499   -7.24343  -0.97593  1.000 32.90330 ? 561  MET   B SD  1 
ATOM   7228 C CE  . MET   B 1 485 ? 8.05996   -5.45906  -0.93325  1.000 20.54759 ? 561  MET   B CE  1 
ATOM   7229 N N   . LYS   B 1 486 ? 12.83778  -9.48125  1.02906   1.000 16.47142 ? 562  LYS   B N   1 
ATOM   7230 C CA  . LYS   B 1 486 ? 13.81636  -10.04945 0.10057   1.000 17.54513 ? 562  LYS   B CA  1 
ATOM   7231 C C   . LYS   B 1 486 ? 13.68435  -11.56512 -0.02210  1.000 20.08863 ? 562  LYS   B C   1 
ATOM   7232 O O   . LYS   B 1 486 ? 13.67316  -12.10874 -1.13218  1.000 15.40578 ? 562  LYS   B O   1 
ATOM   7233 C CB  . LYS   B 1 486 ? 15.23104  -9.67934  0.53859   1.000 14.90104 ? 562  LYS   B CB  1 
ATOM   7234 C CG  . LYS   B 1 486 ? 16.31519  -10.24006 -0.36045  1.000 16.01726 ? 562  LYS   B CG  1 
ATOM   7235 C CD  . LYS   B 1 486 ? 17.56620  -9.39413  -0.24804  1.000 29.80495 ? 562  LYS   B CD  1 
ATOM   7236 C CE  . LYS   B 1 486 ? 18.81633  -10.14861 -0.65848  1.000 34.78318 ? 562  LYS   B CE  1 
ATOM   7237 N NZ  . LYS   B 1 486 ? 19.99378  -9.58335  0.05698   1.000 30.13763 ? 562  LYS   B NZ  1 
ATOM   7238 N N   . GLU   B 1 487 ? 13.57852  -12.26547 1.11269   1.000 15.42680 ? 563  GLU   B N   1 
ATOM   7239 C CA  . GLU   B 1 487 ? 13.49798  -13.72365 1.06349   1.000 18.93377 ? 563  GLU   B CA  1 
ATOM   7240 C C   . GLU   B 1 487 ? 12.23657  -14.19737 0.35606   1.000 20.25719 ? 563  GLU   B C   1 
ATOM   7241 O O   . GLU   B 1 487 ? 12.26150  -15.22963 -0.31891  1.000 18.77439 ? 563  GLU   B O   1 
ATOM   7242 C CB  . GLU   B 1 487 ? 13.57178  -14.30712 2.47404   1.000 20.77958 ? 563  GLU   B CB  1 
ATOM   7243 C CG  . GLU   B 1 487 ? 14.92511  -14.09465 3.13700   1.000 15.65225 ? 563  GLU   B CG  1 
ATOM   7244 C CD  . GLU   B 1 487 ? 15.02477  -12.73203 3.80879   1.000 29.99333 ? 563  GLU   B CD  1 
ATOM   7245 O OE1 . GLU   B 1 487 ? 13.97995  -12.05813 3.95899   1.000 22.00620 ? 563  GLU   B OE1 1 
ATOM   7246 O OE2 . GLU   B 1 487 ? 16.14330  -12.33030 4.19323   1.000 27.12528 ? 563  GLU   B OE2 1 
ATOM   7247 N N   . LEU   B 1 488 ? 11.13100  -13.45612 0.48595   1.000 18.67497 ? 564  LEU   B N   1 
ATOM   7248 C CA  . LEU   B 1 488 ? 9.90754   -13.81738 -0.22486  1.000 14.53874 ? 564  LEU   B CA  1 
ATOM   7249 C C   . LEU   B 1 488 ? 10.07501  -13.69839 -1.73121  1.000 19.97413 ? 564  LEU   B C   1 
ATOM   7250 O O   . LEU   B 1 488 ? 9.46576   -14.46895 -2.48604  1.000 17.19006 ? 564  LEU   B O   1 
ATOM   7251 C CB  . LEU   B 1 488 ? 8.74119   -12.93712 0.22002   1.000 16.92170 ? 564  LEU   B CB  1 
ATOM   7252 C CG  . LEU   B 1 488 ? 8.46311   -12.81487 1.71575   1.000 23.90903 ? 564  LEU   B CG  1 
ATOM   7253 C CD1 . LEU   B 1 488 ? 7.35852   -11.79400 1.95575   1.000 20.57455 ? 564  LEU   B CD1 1 
ATOM   7254 C CD2 . LEU   B 1 488 ? 8.08957   -14.18815 2.29613   1.000 30.87906 ? 564  LEU   B CD2 1 
ATOM   7255 N N   . LEU   B 1 489 ? 10.89020  -12.74232 -2.18491  1.000 19.21310 ? 565  LEU   B N   1 
ATOM   7256 C CA  . LEU   B 1 489 ? 11.01437  -12.47489 -3.61073  1.000 19.01835 ? 565  LEU   B CA  1 
ATOM   7257 C C   . LEU   B 1 489 ? 11.80344  -13.55299 -4.33739  1.000 22.48521 ? 565  LEU   B C   1 
ATOM   7258 O O   . LEU   B 1 489 ? 11.64452  -13.71031 -5.55294  1.000 20.98310 ? 565  LEU   B O   1 
ATOM   7259 C CB  . LEU   B 1 489 ? 11.67221  -11.11041 -3.83385  1.000 16.81173 ? 565  LEU   B CB  1 
ATOM   7260 C CG  . LEU   B 1 489 ? 10.98314  -9.89330  -3.22083  1.000 16.49441 ? 565  LEU   B CG  1 
ATOM   7261 C CD1 . LEU   B 1 489 ? 11.90862  -8.70259  -3.29782  1.000 17.73505 ? 565  LEU   B CD1 1 
ATOM   7262 C CD2 . LEU   B 1 489 ? 9.66814   -9.58805  -3.91828  1.000 23.35099 ? 565  LEU   B CD2 1 
ATOM   7263 N N   . VAL   B 1 490 ? 12.64460  -14.30002 -3.62829  1.000 21.06486 ? 566  VAL   B N   1 
ATOM   7264 C CA  . VAL   B 1 490 ? 13.49208  -15.30977 -4.24627  1.000 20.34251 ? 566  VAL   B CA  1 
ATOM   7265 C C   . VAL   B 1 490 ? 13.08397  -16.71892 -3.87205  1.000 31.76091 ? 566  VAL   B C   1 
ATOM   7266 O O   . VAL   B 1 490 ? 13.71057  -17.67465 -4.34899  1.000 26.43566 ? 566  VAL   B O   1 
ATOM   7267 C CB  . VAL   B 1 490 ? 14.97596  -15.07755 -3.91332  1.000 19.49396 ? 566  VAL   B CB  1 
ATOM   7268 C CG1 . VAL   B 1 490 ? 15.38587  -13.64714 -4.27965  1.000 21.77405 ? 566  VAL   B CG1 1 
ATOM   7269 C CG2 . VAL   B 1 490 ? 15.23686  -15.35617 -2.43420  1.000 25.60941 ? 566  VAL   B CG2 1 
ATOM   7270 N N   . ALA   B 1 491 ? 12.05426  -16.88511 -3.04359  1.000 24.64221 ? 567  ALA   B N   1 
ATOM   7271 C CA  . ALA   B 1 491 ? 11.58908  -18.21746 -2.68562  1.000 27.17637 ? 567  ALA   B CA  1 
ATOM   7272 C C   . ALA   B 1 491 ? 10.99433  -18.92400 -3.89828  1.000 23.87231 ? 567  ALA   B C   1 
ATOM   7273 O O   . ALA   B 1 491 ? 10.41216  -18.29675 -4.78789  1.000 25.47585 ? 567  ALA   B O   1 
ATOM   7274 C CB  . ALA   B 1 491 ? 10.55573  -18.13747 -1.56261  1.000 19.62682 ? 567  ALA   B CB  1 
ATOM   7275 N N   . THR   B 1 492 ? 11.15270  -20.25160 -3.92832  1.000 26.02419 ? 568  THR   B N   1 
ATOM   7276 C CA  . THR   B 1 492 ? 10.62108  -21.04218 -5.03730  1.000 22.16137 ? 568  THR   B CA  1 
ATOM   7277 C C   . THR   B 1 492 ? 9.12411   -20.82068 -5.20068  1.000 27.11502 ? 568  THR   B C   1 
ATOM   7278 O O   . THR   B 1 492 ? 8.63376   -20.57268 -6.30853  1.000 27.30040 ? 568  THR   B O   1 
ATOM   7279 C CB  . THR   B 1 492 ? 10.92057  -22.52628 -4.81804  1.000 28.73864 ? 568  THR   B CB  1 
ATOM   7280 O OG1 . THR   B 1 492 ? 12.33981  -22.73762 -4.81068  1.000 28.78383 ? 568  THR   B OG1 1 
ATOM   7281 C CG2 . THR   B 1 492 ? 10.27872  -23.36446 -5.91220  1.000 25.66356 ? 568  THR   B CG2 1 
ATOM   7282 N N   . LYS   B 1 493 ? 8.38439   -20.88831 -4.10416  1.000 23.53773 ? 569  LYS   B N   1 
ATOM   7283 C CA  . LYS   B 1 493 ? 6.95771   -20.60521 -4.11947  1.000 27.84296 ? 569  LYS   B CA  1 
ATOM   7284 C C   . LYS   B 1 493 ? 6.75518   -19.13290 -3.77723  1.000 27.29524 ? 569  LYS   B C   1 
ATOM   7285 O O   . LYS   B 1 493 ? 7.22933   -18.65533 -2.73753  1.000 25.99939 ? 569  LYS   B O   1 
ATOM   7286 C CB  . LYS   B 1 493 ? 6.21758   -21.51088 -3.13813  1.000 24.40895 ? 569  LYS   B CB  1 
ATOM   7287 C CG  . LYS   B 1 493 ? 4.80356   -21.85274 -3.57001  1.000 32.83565 ? 569  LYS   B CG  1 
ATOM   7288 C CD  . LYS   B 1 493 ? 3.91679   -22.16891 -2.37660  1.000 43.45373 ? 569  LYS   B CD  1 
ATOM   7289 C CE  . LYS   B 1 493 ? 2.58805   -22.74675 -2.83479  1.000 48.22601 ? 569  LYS   B CE  1 
ATOM   7290 N NZ  . LYS   B 1 493 ? 2.71386   -24.20910 -3.09917  1.000 54.25470 ? 569  LYS   B NZ  1 
ATOM   7291 N N   . ILE   B 1 494 ? 6.07674   -18.41238 -4.65972  1.000 21.61163 ? 570  ILE   B N   1 
ATOM   7292 C CA  . ILE   B 1 494 ? 5.88215   -16.97837 -4.49594  1.000 22.79307 ? 570  ILE   B CA  1 
ATOM   7293 C C   . ILE   B 1 494 ? 4.65345   -16.75616 -3.62403  1.000 27.47651 ? 570  ILE   B C   1 
ATOM   7294 O O   . ILE   B 1 494 ? 3.54392   -17.16582 -3.97673  1.000 24.95003 ? 570  ILE   B O   1 
ATOM   7295 C CB  . ILE   B 1 494 ? 5.76201   -16.27989 -5.85855  1.000 23.65280 ? 570  ILE   B CB  1 
ATOM   7296 C CG1 . ILE   B 1 494 ? 7.11248   -16.39245 -6.58359  1.000 22.50915 ? 570  ILE   B CG1 1 
ATOM   7297 C CG2 . ILE   B 1 494 ? 5.33018   -14.81372 -5.68410  1.000 24.05329 ? 570  ILE   B CG2 1 
ATOM   7298 C CD1 . ILE   B 1 494 ? 7.12837   -15.89032 -8.01201  1.000 23.84948 ? 570  ILE   B CD1 1 
ATOM   7299 N N   . ASN   B 1 495 ? 4.86414   -16.12737 -2.46765  1.000 20.75595 ? 571  ASN   B N   1 
ATOM   7300 C CA  . ASN   B 1 495 ? 3.82174   -15.90636 -1.47001  1.000 25.88508 ? 571  ASN   B CA  1 
ATOM   7301 C C   . ASN   B 1 495 ? 3.14594   -14.57810 -1.78198  1.000 26.98006 ? 571  ASN   B C   1 
ATOM   7302 O O   . ASN   B 1 495 ? 3.54208   -13.52542 -1.28286  1.000 21.11331 ? 571  ASN   B O   1 
ATOM   7303 C CB  . ASN   B 1 495 ? 4.42223   -15.91963 -0.07050  1.000 27.71310 ? 571  ASN   B CB  1 
ATOM   7304 C CG  . ASN   B 1 495 ? 3.36969   -15.92413 1.01752   1.000 29.71896 ? 571  ASN   B CG  1 
ATOM   7305 O OD1 . ASN   B 1 495 ? 2.26282   -15.40928 0.83481   1.000 22.59932 ? 571  ASN   B OD1 1 
ATOM   7306 N ND2 . ASN   B 1 495 ? 3.71751   -16.48766 2.16961   1.000 29.91537 ? 571  ASN   B ND2 1 
ATOM   7307 N N   . SER   B 1 496 ? 2.09005   -14.64056 -2.60101  1.000 23.93563 ? 572  SER   B N   1 
ATOM   7308 C CA  . SER   B 1 496 ? 1.43467   -13.42876 -3.08376  1.000 25.48360 ? 572  SER   B CA  1 
ATOM   7309 C C   . SER   B 1 496 ? 0.89646   -12.57178 -1.94409  1.000 23.48302 ? 572  SER   B C   1 
ATOM   7310 O O   . SER   B 1 496 ? 1.06592   -11.34721 -1.95325  1.000 27.93732 ? 572  SER   B O   1 
ATOM   7311 C CB  . SER   B 1 496 ? 0.31738   -13.80118 -4.05996  1.000 31.55218 ? 572  SER   B CB  1 
ATOM   7312 O OG  . SER   B 1 496 ? -0.89017  -14.08616 -3.37844  1.000 35.20710 ? 572  SER   B OG  1 
ATOM   7313 N N   . SER   B 1 497 ? 0.24662   -13.18155 -0.94714  1.000 22.27445 ? 573  SER   B N   1 
ATOM   7314 C CA  . SER   B 1 497 ? -0.39442  -12.35866 0.07836   1.000 19.74489 ? 573  SER   B CA  1 
ATOM   7315 C C   . SER   B 1 497 ? 0.63625   -11.69112 0.98236   1.000 23.20507 ? 573  SER   B C   1 
ATOM   7316 O O   . SER   B 1 497 ? 0.44132   -10.54835 1.41565   1.000 19.43236 ? 573  SER   B O   1 
ATOM   7317 C CB  . SER   B 1 497 ? -1.37120  -13.19352 0.90884   1.000 21.20266 ? 573  SER   B CB  1 
ATOM   7318 O OG  . SER   B 1 497 ? -0.68367  -14.02071 1.82281   1.000 28.09787 ? 573  SER   B OG  1 
ATOM   7319 N N   . ALA   B 1 498 ? 1.73522   -12.38908 1.28815   1.000 20.93833 ? 574  ALA   B N   1 
ATOM   7320 C CA  . ALA   B 1 498 ? 2.77369   -11.78850 2.12124   1.000 26.35482 ? 574  ALA   B CA  1 
ATOM   7321 C C   . ALA   B 1 498 ? 3.51346   -10.68470 1.37415   1.000 23.23917 ? 574  ALA   B C   1 
ATOM   7322 O O   . ALA   B 1 498 ? 3.91658   -9.68292  1.97602   1.000 19.87602 ? 574  ALA   B O   1 
ATOM   7323 C CB  . ALA   B 1 498 ? 3.75574   -12.85745 2.59962   1.000 23.86994 ? 574  ALA   B CB  1 
ATOM   7324 N N   . ILE   B 1 499 ? 3.72051   -10.86008 0.06841   1.000 20.30539 ? 575  ILE   B N   1 
ATOM   7325 C CA  . ILE   B 1 499 ? 4.37264   -9.81544  -0.71778  1.000 19.62810 ? 575  ILE   B CA  1 
ATOM   7326 C C   . ILE   B 1 499 ? 3.45924   -8.60219  -0.84004  1.000 21.72587 ? 575  ILE   B C   1 
ATOM   7327 O O   . ILE   B 1 499 ? 3.90325   -7.45708  -0.70087  1.000 18.97163 ? 575  ILE   B O   1 
ATOM   7328 C CB  . ILE   B 1 499 ? 4.79260   -10.37118 -2.09180  1.000 19.01333 ? 575  ILE   B CB  1 
ATOM   7329 C CG1 . ILE   B 1 499 ? 5.93745   -11.37338 -1.92134  1.000 17.25783 ? 575  ILE   B CG1 1 
ATOM   7330 C CG2 . ILE   B 1 499 ? 5.22182   -9.24660  -3.03289  1.000 23.08406 ? 575  ILE   B CG2 1 
ATOM   7331 C CD1 . ILE   B 1 499 ? 6.23420   -12.16844 -3.16406  1.000 19.38993 ? 575  ILE   B CD1 1 
ATOM   7332 N N   . LYS   B 1 500 ? 2.16477   -8.84084  -1.06619  1.000 17.70341 ? 576  LYS   B N   1 
ATOM   7333 C CA  . LYS   B 1 500 ? 1.19251   -7.75799  -1.14655  1.000 24.93431 ? 576  LYS   B CA  1 
ATOM   7334 C C   . LYS   B 1 500 ? 1.10393   -6.99518  0.17115   1.000 24.84495 ? 576  LYS   B C   1 
ATOM   7335 O O   . LYS   B 1 500 ? 0.97417   -5.76548  0.17764   1.000 27.83353 ? 576  LYS   B O   1 
ATOM   7336 C CB  . LYS   B 1 500 ? -0.16328  -8.34128  -1.56013  1.000 20.50687 ? 576  LYS   B CB  1 
ATOM   7337 C CG  . LYS   B 1 500 ? -1.28930  -7.36611  -1.79753  1.000 25.80232 ? 576  LYS   B CG  1 
ATOM   7338 C CD  . LYS   B 1 500 ? -2.60678  -7.96972  -1.34995  1.000 36.41038 ? 576  LYS   B CD  1 
ATOM   7339 C CE  . LYS   B 1 500 ? -3.77030  -7.33334  -2.07324  1.000 36.71705 ? 576  LYS   B CE  1 
ATOM   7340 N NZ  . LYS   B 1 500 ? -5.03056  -8.08778  -1.81634  1.000 48.75522 ? 576  LYS   B NZ  1 
ATOM   7341 N N   . LEU   B 1 501 ? 1.19745   -7.70251  1.29878   1.000 23.73221 ? 577  LEU   B N   1 
ATOM   7342 C CA  . LEU   B 1 501 ? 1.10174   -7.03983  2.59625   1.000 26.39054 ? 577  LEU   B CA  1 
ATOM   7343 C C   . LEU   B 1 501 ? 2.28740   -6.11042  2.82427   1.000 30.39756 ? 577  LEU   B C   1 
ATOM   7344 O O   . LEU   B 1 501 ? 2.11469   -4.95433  3.23022   1.000 27.08887 ? 577  LEU   B O   1 
ATOM   7345 C CB  . LEU   B 1 501 ? 1.01567   -8.07889  3.71731   1.000 29.32428 ? 577  LEU   B CB  1 
ATOM   7346 C CG  . LEU   B 1 501 ? 1.06620   -7.56154  5.16229   1.000 29.70359 ? 577  LEU   B CG  1 
ATOM   7347 C CD1 . LEU   B 1 501 ? 0.02391   -6.48218  5.40258   1.000 39.83075 ? 577  LEU   B CD1 1 
ATOM   7348 C CD2 . LEU   B 1 501 ? 0.91228   -8.69551  6.17494   1.000 28.17820 ? 577  LEU   B CD2 1 
ATOM   7349 N N   . GLN   B 1 502 ? 3.50528   -6.59923  2.57384   1.000 20.99564 ? 578  GLN   B N   1 
ATOM   7350 C CA  . GLN   B 1 502 ? 4.68160   -5.76646  2.80746   1.000 27.93351 ? 578  GLN   B CA  1 
ATOM   7351 C C   . GLN   B 1 502 ? 4.79183   -4.64289  1.78012   1.000 20.95480 ? 578  GLN   B C   1 
ATOM   7352 O O   . GLN   B 1 502 ? 5.22245   -3.53413  2.11634   1.000 22.69829 ? 578  GLN   B O   1 
ATOM   7353 C CB  . GLN   B 1 502 ? 5.94475   -6.62893  2.81159   1.000 26.37534 ? 578  GLN   B CB  1 
ATOM   7354 C CG  . GLN   B 1 502 ? 7.23912   -5.85766  2.53344   1.000 34.60710 ? 578  GLN   B CG  1 
ATOM   7355 C CD  . GLN   B 1 502 ? 7.80959   -5.12030  3.74578   1.000 43.65367 ? 578  GLN   B CD  1 
ATOM   7356 O OE1 . GLN   B 1 502 ? 8.88263   -5.46930  4.22855   1.000 37.88953 ? 578  GLN   B OE1 1 
ATOM   7357 N NE2 . GLN   B 1 502 ? 7.12084   -4.06350  4.20466   1.000 33.62651 ? 578  GLN   B NE2 1 
ATOM   7358 N N   . LEU   B 1 503 ? 4.40937   -4.90987  0.52970   1.000 17.78629 ? 579  LEU   B N   1 
ATOM   7359 C CA  . LEU   B 1 503 ? 4.54309   -3.90320  -0.51794  1.000 19.86821 ? 579  LEU   B CA  1 
ATOM   7360 C C   . LEU   B 1 503 ? 3.71633   -2.66255  -0.20939  1.000 22.97364 ? 579  LEU   B C   1 
ATOM   7361 O O   . LEU   B 1 503 ? 4.14624   -1.53457  -0.48088  1.000 18.73525 ? 579  LEU   B O   1 
ATOM   7362 C CB  . LEU   B 1 503 ? 4.13152   -4.47980  -1.87000  1.000 14.98303 ? 579  LEU   B CB  1 
ATOM   7363 C CG  . LEU   B 1 503 ? 4.34914   -3.47903  -3.01141  1.000 16.64349 ? 579  LEU   B CG  1 
ATOM   7364 C CD1 . LEU   B 1 503 ? 5.84111   -3.26047  -3.25467  1.000 19.45497 ? 579  LEU   B CD1 1 
ATOM   7365 C CD2 . LEU   B 1 503 ? 3.61660   -3.89042  -4.29662  1.000 13.40767 ? 579  LEU   B CD2 1 
ATOM   7366 N N   . THR   B 1 504 ? 2.53886   -2.84774  0.37057   1.000 19.49074 ? 580  THR   B N   1 
ATOM   7367 C CA  . THR   B 1 504 ? 1.59153   -1.76159  0.56856   1.000 24.08203 ? 580  THR   B CA  1 
ATOM   7368 C C   . THR   B 1 504 ? 1.54968   -1.27286  2.00736   1.000 26.00741 ? 580  THR   B C   1 
ATOM   7369 O O   . THR   B 1 504 ? 0.62576   -0.53838  2.37106   1.000 32.30026 ? 580  THR   B O   1 
ATOM   7370 C CB  . THR   B 1 504 ? 0.19662   -2.20550  0.12973   1.000 22.79414 ? 580  THR   B CB  1 
ATOM   7371 O OG1 . THR   B 1 504 ? -0.22827  -3.31062  0.93847   1.000 22.95463 ? 580  THR   B OG1 1 
ATOM   7372 C CG2 . THR   B 1 504 ? 0.21387   -2.64080  -1.32642  1.000 22.20392 ? 580  THR   B CG2 1 
ATOM   7373 N N   . ALA   B 1 505 ? 2.52525   -1.65886  2.82828   1.000 26.66171 ? 581  ALA   B N   1 
ATOM   7374 C CA  . ALA   B 1 505 ? 2.56219   -1.25918  4.22965   1.000 34.76628 ? 581  ALA   B CA  1 
ATOM   7375 C C   . ALA   B 1 505 ? 2.81974   0.24430   4.37197   1.000 41.13743 ? 581  ALA   B C   1 
ATOM   7376 O O   . ALA   B 1 505 ? 3.35122   0.90251   3.47373   1.000 29.50354 ? 581  ALA   B O   1 
ATOM   7377 C CB  . ALA   B 1 505 ? 3.63787   -2.04923  4.97795   1.000 25.54699 ? 581  ALA   B CB  1 
ATOM   7378 N N   . GLN   B 1 506 ? 2.44839   0.78180   5.53362   1.000 46.78635 ? 582  GLN   B N   1 
ATOM   7379 C CA  . GLN   B 1 506 ? 2.51917   2.22660   5.78785   1.000 45.87619 ? 582  GLN   B CA  1 
ATOM   7380 C C   . GLN   B 1 506 ? 3.91614   2.75069   6.12906   1.000 37.72211 ? 582  GLN   B C   1 
ATOM   7381 O O   . GLN   B 1 506 ? 4.90410   2.02004   6.09613   1.000 40.66510 ? 582  GLN   B O   1 
ATOM   7382 C CB  . GLN   B 1 506 ? 1.55899   2.60484   6.91841   1.000 45.55675 ? 582  GLN   B CB  1 
ATOM   7383 C CG  . GLN   B 1 506 ? 0.10502   2.61881   6.50009   1.000 54.01826 ? 582  GLN   B CG  1 
ATOM   7384 C CD  . GLN   B 1 506 ? -0.40442  4.02713   6.26720   1.000 58.58654 ? 582  GLN   B CD  1 
ATOM   7385 O OE1 . GLN   B 1 506 ? 0.35169   4.99550   6.37289   1.000 56.99352 ? 582  GLN   B OE1 1 
ATOM   7386 N NE2 . GLN   B 1 506 ? -1.68763  4.14959   5.93586   1.000 62.79228 ? 582  GLN   B NE2 1 
HETATM 7387 N N6  . A1AVF C 2 .   ? -16.50611 -16.20604 -25.03627 1.000 14.27744 ? 901  A1AVF A N6  1 
HETATM 7388 C C18 . A1AVF C 2 .   ? -14.09752 -15.65810 -21.72517 1.000 12.76836 ? 901  A1AVF A C18 1 
HETATM 7389 N N5  . A1AVF C 2 .   ? -15.77167 -16.01664 -23.92879 1.000 12.86752 ? 901  A1AVF A N5  1 
HETATM 7390 C C13 . A1AVF C 2 .   ? -14.46155 -8.47427  -24.48800 1.000 12.46374 ? 901  A1AVF A C13 1 
HETATM 7391 C C12 . A1AVF C 2 .   ? -14.26463 -9.74866  -23.64826 1.000 11.58149 ? 901  A1AVF A C12 1 
HETATM 7392 C C17 . A1AVF C 2 .   ? -13.32543 -6.70085  -25.79061 1.000 15.12548 ? 901  A1AVF A C17 1 
HETATM 7393 C C16 . A1AVF C 2 .   ? -12.24472 -10.27820 -24.95660 1.000 11.73178 ? 901  A1AVF A C16 1 
HETATM 7394 C C15 . A1AVF C 2 .   ? -12.45065 -9.00033  -25.79432 1.000 17.99791 ? 901  A1AVF A C15 1 
HETATM 7395 C C11 . A1AVF C 2 .   ? -14.48341 -11.53148 -25.48376 1.000 11.88956 ? 901  A1AVF A C11 1 
HETATM 7396 C C10 . A1AVF C 2 .   ? -13.57599 -10.86098 -24.43962 1.000 9.29619  ? 901  A1AVF A C10 1 
HETATM 7397 C C22 . A1AVF C 2 .   ? -14.98074 -16.90436 -19.83746 1.000 11.97409 ? 901  A1AVF A C22 1 
HETATM 7398 N N2  . A1AVF C 2 .   ? -15.70617 -14.15674 -25.97674 1.000 9.86461  ? 901  A1AVF A N2  1 
HETATM 7399 C C1  . A1AVF C 2 .   ? -16.44759 -15.28228 -26.01163 1.000 8.53985  ? 901  A1AVF A C1  1 
HETATM 7400 C C4  . A1AVF C 2 .   ? -14.99442 -14.91782 -23.83943 1.000 14.28557 ? 901  A1AVF A C4  1 
HETATM 7401 C C19 . A1AVF C 2 .   ? -12.85246 -16.31884 -21.60740 1.000 11.17988 ? 901  A1AVF A C19 1 
HETATM 7402 C C20 . A1AVF C 2 .   ? -12.66287 -17.28566 -20.60260 1.000 13.71552 ? 901  A1AVF A C20 1 
HETATM 7403 C C21 . A1AVF C 2 .   ? -13.73934 -17.56712 -19.73413 1.000 11.74652 ? 901  A1AVF A C21 1 
HETATM 7404 C C3  . A1AVF C 2 .   ? -14.97193 -13.94456 -24.86412 1.000 10.94241 ? 901  A1AVF A C3  1 
HETATM 7405 C C23 . A1AVF C 2 .   ? -15.16000 -15.93926 -20.84438 1.000 10.32416 ? 901  A1AVF A C23 1 
HETATM 7406 C C25 . A1AVF C 2 .   ? -11.74223 -15.98972 -22.58773 1.000 16.28105 ? 901  A1AVF A C25 1 
HETATM 7407 C C27 . A1AVF C 2 .   ? -14.11321 -5.61981  -25.06726 1.000 17.35322 ? 901  A1AVF A C27 1 
HETATM 7408 C C28 . A1AVF C 2 .   ? -14.77074 -4.55006  -25.90330 1.000 14.43030 ? 901  A1AVF A C28 1 
HETATM 7409 C C29 . A1AVF C 2 .   ? -15.61793 -5.59557  -25.22176 1.000 14.08747 ? 901  A1AVF A C29 1 
HETATM 7410 C C30 . A1AVF C 2 .   ? -13.50207 -5.20653  -23.73622 1.000 13.98907 ? 901  A1AVF A C30 1 
HETATM 7411 C C31 . A1AVF C 2 .   ? -12.11939 -15.65483 -25.04374 1.000 15.68192 ? 901  A1AVF A C31 1 
HETATM 7412 C C33 . A1AVF C 2 .   ? -12.67779 -17.71396 -24.15755 1.000 16.30319 ? 901  A1AVF A C33 1 
HETATM 7413 C C34 . A1AVF C 2 .   ? -12.98347 -17.78024 -25.62356 1.000 14.57190 ? 901  A1AVF A C34 1 
HETATM 7414 C C35 . A1AVF C 2 .   ? -12.65774 -16.43551 -26.25613 1.000 14.46792 ? 901  A1AVF A C35 1 
HETATM 7415 C C36 . A1AVF C 2 .   ? -11.81571 -18.56686 -25.06372 1.000 17.98616 ? 901  A1AVF A C36 1 
HETATM 7416 C C9  . A1AVF C 2 .   ? -13.48235 -12.19596 -23.67998 1.000 11.54090 ? 901  A1AVF A C9  1 
HETATM 7417 F F24 . A1AVF C 2 .   ? -13.58662 -18.47947 -18.76884 1.000 15.34436 ? 901  A1AVF A F24 1 
HETATM 7418 N N14 . A1AVF C 2 .   ? -13.16583 -7.95836  -25.00315 1.000 13.40343 ? 901  A1AVF A N14 1 
HETATM 7419 N N26 . A1AVF C 2 .   ? -12.13980 -16.41809 -23.93214 1.000 15.50768 ? 901  A1AVF A N26 1 
HETATM 7420 N N8  . A1AVF C 2 .   ? -14.15248 -12.77781 -24.83040 1.000 12.12602 ? 901  A1AVF A N8  1 
HETATM 7421 O O32 . A1AVF C 2 .   ? -11.57891 -14.54957 -25.12652 1.000 14.55626 ? 901  A1AVF A O32 1 
HETATM 7422 O O7  . A1AVF C 2 .   ? -14.24456 -14.71422 -22.69977 1.000 12.33738 ? 901  A1AVF A O7  1 
HETATM 7423 K K   . K     D 3 .   ? -20.67396 -2.23732  -4.28468  1.000 35.63349 ? 902  K     A K   1 
HETATM 7424 N N1  . EPE   E 4 .   ? -6.36619  37.18533  -13.19950 1.000 38.79126 ? 601  EPE   B N1  1 
HETATM 7425 C C2  . EPE   E 4 .   ? -6.05483  36.63580  -11.87396 1.000 29.12469 ? 601  EPE   B C2  1 
HETATM 7426 C C3  . EPE   E 4 .   ? -4.91395  35.64270  -12.04451 1.000 28.12071 ? 601  EPE   B C3  1 
HETATM 7427 N N4  . EPE   E 4 .   ? -5.16518  34.67434  -13.10223 1.000 30.75950 ? 601  EPE   B N4  1 
HETATM 7428 C C5  . EPE   E 4 .   ? -5.80532  35.10989  -14.33290 1.000 28.32209 ? 601  EPE   B C5  1 
HETATM 7429 C C6  . EPE   E 4 .   ? -6.90127  36.13724  -14.08261 1.000 31.08870 ? 601  EPE   B C6  1 
HETATM 7430 C C7  . EPE   E 4 .   ? -4.24785  33.55934  -13.20075 1.000 29.95993 ? 601  EPE   B C7  1 
HETATM 7431 C C8  . EPE   E 4 .   ? -4.73089  32.47782  -14.15628 1.000 35.09725 ? 601  EPE   B C8  1 
HETATM 7432 O O8  . EPE   E 4 .   ? -5.73197  31.71667  -13.52186 1.000 40.89518 ? 601  EPE   B O8  1 
HETATM 7433 C C9  . EPE   E 4 .   ? -7.34864  38.26377  -13.05856 1.000 42.97149 ? 601  EPE   B C9  1 
HETATM 7434 C C10 . EPE   E 4 .   ? -6.57008  39.53121  -12.75343 1.000 40.11922 ? 601  EPE   B C10 1 
HETATM 7435 S S   . EPE   E 4 .   ? -7.57557  41.02403  -12.92517 1.000 60.09911 ? 601  EPE   B S   1 
HETATM 7436 O O1S . EPE   E 4 .   ? -7.55697  41.43576  -14.32965 1.000 46.44618 ? 601  EPE   B O1S 1 
HETATM 7437 O O2S . EPE   E 4 .   ? -8.95190  40.74701  -12.52497 1.000 48.70972 ? 601  EPE   B O2S 1 
HETATM 7438 O O3S . EPE   E 4 .   ? -7.00131  42.06494  -12.07291 1.000 55.50060 ? 601  EPE   B O3S 1 
HETATM 7439 S S   . SO4   F 5 .   ? 15.39612  -10.33116 -24.58020 1.000 31.85162 ? 602  SO4   B S   1 
HETATM 7440 O O1  . SO4   F 5 .   ? 14.51240  -9.51286  -25.40753 1.000 31.07230 ? 602  SO4   B O1  1 
HETATM 7441 O O2  . SO4   F 5 .   ? 14.62320  -11.37369 -23.89180 1.000 20.44481 ? 602  SO4   B O2  1 
HETATM 7442 O O3  . SO4   F 5 .   ? 16.39679  -10.95788 -25.46589 1.000 43.91974 ? 602  SO4   B O3  1 
HETATM 7443 O O4  . SO4   F 5 .   ? 16.12255  -9.47858  -23.62898 1.000 27.12911 ? 602  SO4   B O4  1 
HETATM 7444 N N6  . A1AVF G 2 .   ? 11.69148  20.53477  -22.55080 1.000 13.15709 ? 603  A1AVF B N6  1 
HETATM 7445 C C18 . A1AVF G 2 .   ? 8.79245   20.17084  -19.60088 1.000 12.14117 ? 603  A1AVF B C18 1 
HETATM 7446 N N5  . A1AVF G 2 .   ? 10.80343  20.39670  -21.55677 1.000 12.77392 ? 603  A1AVF B N5  1 
HETATM 7447 C C13 . A1AVF G 2 .   ? 7.82363   13.30620  -23.28510 1.000 12.21272 ? 603  A1AVF B C13 1 
HETATM 7448 C C12 . A1AVF G 2 .   ? 7.48733   14.63706  -22.59305 1.000 14.07573 ? 603  A1AVF B C12 1 
HETATM 7449 C C17 . A1AVF G 2 .   ? 8.77696   11.08222  -22.99414 1.000 10.81433 ? 603  A1AVF B C17 1 
HETATM 7450 C C16 . A1AVF G 2 .   ? 9.28410   14.23081  -20.96820 1.000 15.04557 ? 603  A1AVF B C16 1 
HETATM 7451 C C15 . A1AVF G 2 .   ? 9.67376   12.93901  -21.68570 1.000 14.19421 ? 603  A1AVF B C15 1 
HETATM 7452 C C11 . A1AVF G 2 .   ? 8.56781   16.66556  -21.37082 1.000 10.67454 ? 603  A1AVF B C11 1 
HETATM 7453 C C10 . A1AVF G 2 .   ? 8.74446   15.26356  -21.96214 1.000 10.94349 ? 603  A1AVF B C10 1 
HETATM 7454 C C22 . A1AVF G 2 .   ? 9.27084   21.46355  -17.59560 1.000 9.56237  ? 603  A1AVF B C22 1 
HETATM 7455 N N2  . A1AVF G 2 .   ? 11.01231  18.45931  -23.49633 1.000 11.13981 ? 603  A1AVF B N2  1 
HETATM 7456 C C1  . A1AVF G 2 .   ? 11.76855  19.56777  -23.47814 1.000 7.03282  ? 603  A1AVF B C1  1 
HETATM 7457 C C4  . A1AVF G 2 .   ? 10.01283  19.31330  -21.52132 1.000 13.51195 ? 603  A1AVF B C4  1 
HETATM 7458 C C19 . A1AVF G 2 .   ? 7.55245   20.83222  -19.73517 1.000 13.18310 ? 603  A1AVF B C19 1 
HETATM 7459 C C20 . A1AVF G 2 .   ? 7.16811   21.82535  -18.81443 1.000 8.31565  ? 603  A1AVF B C20 1 
HETATM 7460 C C21 . A1AVF G 2 .   ? 8.03185   22.12853  -17.74675 1.000 10.95914 ? 603  A1AVF B C21 1 
HETATM 7461 C C3  . A1AVF G 2 .   ? 10.11789  18.30413  -22.49998 1.000 11.93111 ? 603  A1AVF B C3  1 
HETATM 7462 C C23 . A1AVF G 2 .   ? 9.65361   20.46442  -18.52081 1.000 11.47046 ? 603  A1AVF B C23 1 
HETATM 7463 C C25 . A1AVF G 2 .   ? 6.63388   20.50218  -20.89565 1.000 13.31945 ? 603  A1AVF B C25 1 
HETATM 7464 C C27 . A1AVF G 2 .   ? 9.37244   10.04341  -22.06336 1.000 12.15344 ? 603  A1AVF B C27 1 
HETATM 7465 C C28 . A1AVF G 2 .   ? 10.15390  8.93625   -22.73156 1.000 16.34445 ? 603  A1AVF B C28 1 
HETATM 7466 C C29 . A1AVF G 2 .   ? 10.87125  9.96618   -21.88759 1.000 17.64099 ? 603  A1AVF B C29 1 
HETATM 7467 C C30 . A1AVF G 2 .   ? 8.47928   9.67992   -20.89400 1.000 16.39473 ? 603  A1AVF B C30 1 
HETATM 7468 C C31 . A1AVF G 2 .   ? 7.43325   20.08197  -23.20880 1.000 15.67611 ? 603  A1AVF B C31 1 
HETATM 7469 C C33 . A1AVF G 2 .   ? 7.74428   22.20954  -22.38317 1.000 16.60904 ? 603  A1AVF B C33 1 
HETATM 7470 C C34 . A1AVF G 2 .   ? 8.27689   22.22161  -23.78603 1.000 15.66699 ? 603  A1AVF B C34 1 
HETATM 7471 C C35 . A1AVF G 2 .   ? 8.12169   20.82708  -24.36305 1.000 14.63984 ? 603  A1AVF B C35 1 
HETATM 7472 C C36 . A1AVF G 2 .   ? 7.01538   22.98759  -23.45301 1.000 12.47999 ? 603  A1AVF B C36 1 
HETATM 7473 C C9  . A1AVF G 2 .   ? 9.80792   15.84888  -22.91937 1.000 12.67492 ? 603  A1AVF B C9  1 
HETATM 7474 F F24 . A1AVF G 2 .   ? 7.65378   23.08355  -16.87841 1.000 12.89464 ? 603  A1AVF B F24 1 
HETATM 7475 N N14 . A1AVF G 2 .   ? 8.46706   12.36728  -22.33215 1.000 10.51117 ? 603  A1AVF B N14 1 
HETATM 7476 N N26 . A1AVF G 2 .   ? 7.20308   20.91023  -22.17803 1.000 13.18777 ? 603  A1AVF B N26 1 
HETATM 7477 N N8  . A1AVF G 2 .   ? 9.29244   17.14627  -22.53659 1.000 15.14459 ? 603  A1AVF B N8  1 
HETATM 7478 O O32 . A1AVF G 2 .   ? 6.98617   18.93740  -23.29761 1.000 15.16863 ? 603  A1AVF B O32 1 
HETATM 7479 O O7  . A1AVF G 2 .   ? 9.10523   19.18750  -20.50287 1.000 12.09124 ? 603  A1AVF B O7  1 
HETATM 7480 K K   . K     H 3 .   ? 12.19249  9.06788   -0.02885  1.000 18.33695 ? 604  K     B K   1 
HETATM 7481 O O   . HOH   I 6 .   ? 10.84494  1.00086   -60.29992 1.000 42.13378 ? 1001 HOH   A O   1 
HETATM 7482 O O   . HOH   I 6 .   ? -23.38212 -31.86023 -6.74691  1.000 33.36641 ? 1002 HOH   A O   1 
HETATM 7483 O O   . HOH   I 6 .   ? -3.42747  -8.22392  -16.92751 1.000 28.12553 ? 1003 HOH   A O   1 
HETATM 7484 O O   . HOH   I 6 .   ? -11.55506 -1.45288  -21.94508 1.000 25.05375 ? 1004 HOH   A O   1 
HETATM 7485 O O   . HOH   I 6 .   ? -5.08226  -12.48349 -29.84606 1.000 25.16558 ? 1005 HOH   A O   1 
HETATM 7486 O O   . HOH   I 6 .   ? 9.43598   -3.73479  -53.31876 1.000 38.99580 ? 1006 HOH   A O   1 
HETATM 7487 O O   . HOH   I 6 .   ? -27.25804 -33.04063 -27.18957 1.000 41.07765 ? 1007 HOH   A O   1 
HETATM 7488 O O   . HOH   I 6 .   ? -15.302   -0.224    4.716     1.000 35.91021 ? 1008 HOH   A O   1 
HETATM 7489 O O   . HOH   I 6 .   ? -9.85423  27.58247  -34.56715 1.000 33.99147 ? 1009 HOH   A O   1 
HETATM 7490 O O   . HOH   I 6 .   ? -18.44160 -0.02610  -39.23804 1.000 29.44953 ? 1010 HOH   A O   1 
HETATM 7491 O O   . HOH   I 6 .   ? -12.86316 -12.03074 -19.78599 1.000 25.51034 ? 1011 HOH   A O   1 
HETATM 7492 O O   . HOH   I 6 .   ? -10.38081 -27.45075 -4.34381  1.000 29.87029 ? 1012 HOH   A O   1 
HETATM 7493 O O   . HOH   I 6 .   ? -16.17787 -34.48590 -27.74771 1.000 26.88826 ? 1013 HOH   A O   1 
HETATM 7494 O O   . HOH   I 6 .   ? -13.62611 -0.93150  -1.34116  1.000 28.89314 ? 1014 HOH   A O   1 
HETATM 7495 O O   . HOH   I 6 .   ? -25.14394 -32.63146 -40.46830 1.000 37.73184 ? 1015 HOH   A O   1 
HETATM 7496 O O   . HOH   I 6 .   ? -8.14975  -0.17520  -23.92737 1.000 33.43480 ? 1016 HOH   A O   1 
HETATM 7497 O O   . HOH   I 6 .   ? 4.14837   -17.20498 -34.14869 1.000 35.27111 ? 1017 HOH   A O   1 
HETATM 7498 O O   . HOH   I 6 .   ? -12.04007 2.08411   5.26389   1.000 29.88788 ? 1018 HOH   A O   1 
HETATM 7499 O O   . HOH   I 6 .   ? -14.55610 -10.49871 -28.83048 1.000 24.37711 ? 1019 HOH   A O   1 
HETATM 7500 O O   . HOH   I 6 .   ? -13.04899 -4.82138  -29.35453 1.000 27.94068 ? 1020 HOH   A O   1 
HETATM 7501 O O   . HOH   I 6 .   ? -10.02302 8.08276   -13.70084 1.000 12.87106 ? 1021 HOH   A O   1 
HETATM 7502 O O   . HOH   I 6 .   ? -27.30674 15.75445  -26.28415 1.000 32.79569 ? 1022 HOH   A O   1 
HETATM 7503 O O   . HOH   I 6 .   ? 1.63418   -33.72763 -15.61234 1.000 33.14661 ? 1023 HOH   A O   1 
HETATM 7504 O O   . HOH   I 6 .   ? -24.30724 -3.81054  -43.81862 1.000 36.99412 ? 1024 HOH   A O   1 
HETATM 7505 O O   . HOH   I 6 .   ? -12.63864 -30.56021 -10.88785 1.000 24.01400 ? 1025 HOH   A O   1 
HETATM 7506 O O   . HOH   I 6 .   ? -14.96569 0.60162   -24.00831 1.000 22.17733 ? 1026 HOH   A O   1 
HETATM 7507 O O   . HOH   I 6 .   ? -10.65570 4.13604   -2.97835  1.000 20.49098 ? 1027 HOH   A O   1 
HETATM 7508 O O   . HOH   I 6 .   ? -4.60580  19.70919  -31.57425 1.000 21.66313 ? 1028 HOH   A O   1 
HETATM 7509 O O   . HOH   I 6 .   ? -28.52405 8.77709   -9.95665  1.000 30.67582 ? 1029 HOH   A O   1 
HETATM 7510 O O   . HOH   I 6 .   ? -22.08768 11.79244  -31.85426 1.000 40.79913 ? 1030 HOH   A O   1 
HETATM 7511 O O   . HOH   I 6 .   ? -0.65642  13.06049  -6.74195  1.000 32.02941 ? 1031 HOH   A O   1 
HETATM 7512 O O   . HOH   I 6 .   ? -11.40507 10.18236  -17.43239 1.000 12.27522 ? 1032 HOH   A O   1 
HETATM 7513 O O   . HOH   I 6 .   ? -25.93383 -40.09836 -11.50937 1.000 37.89460 ? 1033 HOH   A O   1 
HETATM 7514 O O   . HOH   I 6 .   ? -17.13618 15.73727  1.06405   1.000 12.87934 ? 1034 HOH   A O   1 
HETATM 7515 O O   . HOH   I 6 .   ? -25.56620 3.37256   -30.03518 1.000 22.70134 ? 1035 HOH   A O   1 
HETATM 7516 O O   . HOH   I 6 .   ? -9.14830  -13.81443 -24.66280 1.000 35.41152 ? 1036 HOH   A O   1 
HETATM 7517 O O   . HOH   I 6 .   ? -10.29589 -14.95271 -29.57075 1.000 5.20366  ? 1037 HOH   A O   1 
HETATM 7518 O O   . HOH   I 6 .   ? -11.12712 -11.98928 -33.10776 1.000 20.62588 ? 1038 HOH   A O   1 
HETATM 7519 O O   . HOH   I 6 .   ? -21.49107 -13.18405 -8.30687  1.000 13.68579 ? 1039 HOH   A O   1 
HETATM 7520 O O   . HOH   I 6 .   ? -11.85578 -21.25119 -48.25915 1.000 29.93397 ? 1040 HOH   A O   1 
HETATM 7521 O O   . HOH   I 6 .   ? -22.95763 -2.45296  -5.14099  1.000 27.45007 ? 1041 HOH   A O   1 
HETATM 7522 O O   . HOH   I 6 .   ? -17.154   1.740     1.423     1.000 30.58251 ? 1042 HOH   A O   1 
HETATM 7523 O O   . HOH   I 6 .   ? -16.14192 -21.75611 -6.51893  1.000 24.93612 ? 1043 HOH   A O   1 
HETATM 7524 O O   . HOH   I 6 .   ? -0.37615  -29.38910 -43.68476 1.000 22.59057 ? 1044 HOH   A O   1 
HETATM 7525 O O   . HOH   I 6 .   ? -4.33922  -19.78064 -25.21131 1.000 12.34714 ? 1045 HOH   A O   1 
HETATM 7526 O O   . HOH   I 6 .   ? 0.12170   -38.34538 -33.74453 1.000 28.41627 ? 1046 HOH   A O   1 
HETATM 7527 O O   . HOH   I 6 .   ? -12.454   6.173     4.782     1.000 26.72380 ? 1047 HOH   A O   1 
HETATM 7528 O O   . HOH   I 6 .   ? -22.26641 -25.58689 -2.29642  1.000 27.42412 ? 1048 HOH   A O   1 
HETATM 7529 O O   . HOH   I 6 .   ? -13.44385 22.01322  -7.77393  1.000 28.71367 ? 1049 HOH   A O   1 
HETATM 7530 O O   . HOH   I 6 .   ? -25.81663 -5.20883  -12.29582 1.000 30.83001 ? 1050 HOH   A O   1 
HETATM 7531 O O   . HOH   I 6 .   ? -6.65186  -9.87554  -15.31172 1.000 26.46350 ? 1051 HOH   A O   1 
HETATM 7532 O O   . HOH   I 6 .   ? -26.69656 -24.09878 -9.30194  1.000 33.38042 ? 1052 HOH   A O   1 
HETATM 7533 O O   . HOH   I 6 .   ? -24.49020 5.27448   -1.47066  1.000 24.93551 ? 1053 HOH   A O   1 
HETATM 7534 O O   . HOH   I 6 .   ? -24.68324 -41.99256 -22.41837 1.000 33.57706 ? 1054 HOH   A O   1 
HETATM 7535 O O   . HOH   I 6 .   ? -4.54983  -37.75946 -16.19567 1.000 24.63784 ? 1055 HOH   A O   1 
HETATM 7536 O O   . HOH   I 6 .   ? -18.88469 5.68144   -2.42954  1.000 17.89851 ? 1056 HOH   A O   1 
HETATM 7537 O O   . HOH   I 6 .   ? -27.81017 -31.86700 -22.40944 1.000 25.96314 ? 1057 HOH   A O   1 
HETATM 7538 O O   . HOH   I 6 .   ? -10.70804 -23.48033 -25.12976 1.000 13.96929 ? 1058 HOH   A O   1 
HETATM 7539 O O   . HOH   I 6 .   ? -4.83080  -23.98857 -30.50413 1.000 25.08192 ? 1059 HOH   A O   1 
HETATM 7540 O O   . HOH   I 6 .   ? -20.30910 -18.17652 -43.08575 1.000 16.32597 ? 1060 HOH   A O   1 
HETATM 7541 O O   . HOH   I 6 .   ? -7.99664  21.97496  -11.98931 1.000 31.87356 ? 1061 HOH   A O   1 
HETATM 7542 O O   . HOH   I 6 .   ? -15.77006 18.55151  -30.56368 1.000 25.99362 ? 1062 HOH   A O   1 
HETATM 7543 O O   . HOH   I 6 .   ? -21.38898 -5.50768  -41.53007 1.000 19.60903 ? 1063 HOH   A O   1 
HETATM 7544 O O   . HOH   I 6 .   ? -25.53039 2.23742   -24.38864 1.000 22.90380 ? 1064 HOH   A O   1 
HETATM 7545 O O   . HOH   I 6 .   ? -8.70006  13.49357  -19.73953 1.000 14.79415 ? 1065 HOH   A O   1 
HETATM 7546 O O   . HOH   I 6 .   ? -1.85616  -9.52887  -32.49014 1.000 24.39676 ? 1066 HOH   A O   1 
HETATM 7547 O O   . HOH   I 6 .   ? 0.32608   -25.55836 -30.89254 1.000 18.71237 ? 1067 HOH   A O   1 
HETATM 7548 O O   . HOH   I 6 .   ? -27.19528 -30.56284 -17.46985 1.000 37.93846 ? 1068 HOH   A O   1 
HETATM 7549 O O   . HOH   I 6 .   ? 10.87978  -8.34346  -53.19674 1.000 43.53168 ? 1069 HOH   A O   1 
HETATM 7550 O O   . HOH   I 6 .   ? -31.22062 -17.33862 -19.51536 1.000 28.33765 ? 1070 HOH   A O   1 
HETATM 7551 O O   . HOH   I 6 .   ? -25.51127 -21.59760 -10.14468 1.000 20.11868 ? 1071 HOH   A O   1 
HETATM 7552 O O   . HOH   I 6 .   ? -8.35360  -18.93486 -24.68117 1.000 14.07917 ? 1072 HOH   A O   1 
HETATM 7553 O O   . HOH   I 6 .   ? 8.08855   -13.06156 -60.19486 1.000 22.94041 ? 1073 HOH   A O   1 
HETATM 7554 O O   . HOH   I 6 .   ? -24.79439 5.67422   -10.83183 1.000 28.75550 ? 1074 HOH   A O   1 
HETATM 7555 O O   . HOH   I 6 .   ? -9.80277  -21.13243 -23.69784 1.000 11.39605 ? 1075 HOH   A O   1 
HETATM 7556 O O   . HOH   I 6 .   ? -14.44193 -13.33763 -28.43460 1.000 17.39163 ? 1076 HOH   A O   1 
HETATM 7557 O O   . HOH   I 6 .   ? -13.16975 -8.61166  -30.81316 1.000 25.46726 ? 1077 HOH   A O   1 
HETATM 7558 O O   . HOH   I 6 .   ? -16.68994 4.36009   -2.95046  1.000 14.18013 ? 1078 HOH   A O   1 
HETATM 7559 O O   . HOH   I 6 .   ? -17.43989 -12.58731 -15.12975 1.000 15.51780 ? 1079 HOH   A O   1 
HETATM 7560 O O   . HOH   I 6 .   ? -29.91854 -10.81023 -39.17340 1.000 35.13954 ? 1080 HOH   A O   1 
HETATM 7561 O O   . HOH   I 6 .   ? -27.96582 -4.24551  -14.48284 1.000 19.88397 ? 1081 HOH   A O   1 
HETATM 7562 O O   . HOH   I 6 .   ? -9.48862  21.22565  -24.05641 1.000 21.78232 ? 1082 HOH   A O   1 
HETATM 7563 O O   . HOH   I 6 .   ? -1.04427  -10.94463 -41.17134 1.000 35.80298 ? 1083 HOH   A O   1 
HETATM 7564 O O   . HOH   I 6 .   ? -4.82353  16.04942  -13.94324 1.000 23.27633 ? 1084 HOH   A O   1 
HETATM 7565 O O   . HOH   I 6 .   ? -23.79682 27.92881  -17.42557 1.000 31.41779 ? 1085 HOH   A O   1 
HETATM 7566 O O   . HOH   I 6 .   ? -4.02698  8.44423   -20.62148 1.000 22.46066 ? 1086 HOH   A O   1 
HETATM 7567 O O   . HOH   I 6 .   ? -17.89962 -13.02526 -43.64097 1.000 29.10666 ? 1087 HOH   A O   1 
HETATM 7568 O O   . HOH   I 6 .   ? -9.37660  -30.14027 -14.53670 1.000 21.39058 ? 1088 HOH   A O   1 
HETATM 7569 O O   . HOH   I 6 .   ? -32.38519 -3.33024  -18.65782 1.000 21.98968 ? 1089 HOH   A O   1 
HETATM 7570 O O   . HOH   I 6 .   ? -22.55763 -40.87044 -12.26572 1.000 28.73936 ? 1090 HOH   A O   1 
HETATM 7571 O O   . HOH   I 6 .   ? -7.54561  -1.62780  -6.52424  1.000 23.04327 ? 1091 HOH   A O   1 
HETATM 7572 O O   . HOH   I 6 .   ? -17.25253 -6.94322  -9.10942  1.000 13.72178 ? 1092 HOH   A O   1 
HETATM 7573 O O   . HOH   I 6 .   ? -23.87701 21.93455  -12.16204 1.000 23.80067 ? 1093 HOH   A O   1 
HETATM 7574 O O   . HOH   I 6 .   ? -10.66573 3.58857   6.32392   1.000 33.80627 ? 1094 HOH   A O   1 
HETATM 7575 O O   . HOH   I 6 .   ? 8.21749   -23.03179 -40.45850 1.000 29.64381 ? 1095 HOH   A O   1 
HETATM 7576 O O   . HOH   I 6 .   ? -13.06486 -3.91727  -34.63573 1.000 23.47174 ? 1096 HOH   A O   1 
HETATM 7577 O O   . HOH   I 6 .   ? -11.03217 -11.32010 -13.40257 1.000 17.94312 ? 1097 HOH   A O   1 
HETATM 7578 O O   . HOH   I 6 .   ? -21.41995 -10.86544 -22.07051 1.000 11.48441 ? 1098 HOH   A O   1 
HETATM 7579 O O   . HOH   I 6 .   ? 6.26606   -11.17267 -51.03081 1.000 25.50442 ? 1099 HOH   A O   1 
HETATM 7580 O O   . HOH   I 6 .   ? 2.38964   -14.79808 -45.08584 1.000 28.31821 ? 1100 HOH   A O   1 
HETATM 7581 O O   . HOH   I 6 .   ? -4.79128  15.62107  -2.67942  1.000 30.76935 ? 1101 HOH   A O   1 
HETATM 7582 O O   . HOH   I 6 .   ? -16.15347 -9.83612  -44.75569 1.000 26.01081 ? 1102 HOH   A O   1 
HETATM 7583 O O   . HOH   I 6 .   ? -23.97104 -28.49386 -7.40500  1.000 33.04445 ? 1103 HOH   A O   1 
HETATM 7584 O O   . HOH   I 6 .   ? -13.76934 -24.08556 -13.00659 1.000 13.57354 ? 1104 HOH   A O   1 
HETATM 7585 O O   . HOH   I 6 .   ? -7.86501  -17.95863 -27.34814 1.000 9.72238  ? 1105 HOH   A O   1 
HETATM 7586 O O   . HOH   I 6 .   ? -3.03418  -42.10695 -33.08230 1.000 27.25292 ? 1106 HOH   A O   1 
HETATM 7587 O O   . HOH   I 6 .   ? -24.41940 12.11911  -13.96762 1.000 18.54494 ? 1107 HOH   A O   1 
HETATM 7588 O O   . HOH   I 6 .   ? -5.15652  -18.96580 -18.56168 1.000 16.91271 ? 1108 HOH   A O   1 
HETATM 7589 O O   . HOH   I 6 .   ? -14.55094 28.02648  -8.61693  1.000 32.13051 ? 1109 HOH   A O   1 
HETATM 7590 O O   . HOH   I 6 .   ? -27.62343 -26.33190 -35.95413 1.000 24.10288 ? 1110 HOH   A O   1 
HETATM 7591 O O   . HOH   I 6 .   ? -13.51923 23.75748  -16.77329 1.000 35.40415 ? 1111 HOH   A O   1 
HETATM 7592 O O   . HOH   I 6 .   ? -10.50748 -17.51278 -17.55298 1.000 17.44485 ? 1112 HOH   A O   1 
HETATM 7593 O O   . HOH   I 6 .   ? -15.97921 -2.99544  -29.78304 1.000 13.11736 ? 1113 HOH   A O   1 
HETATM 7594 O O   . HOH   I 6 .   ? -4.26493  11.67879  -20.78421 1.000 27.20562 ? 1114 HOH   A O   1 
HETATM 7595 O O   . HOH   I 6 .   ? -26.02779 -6.70594  -19.47875 1.000 9.76178  ? 1115 HOH   A O   1 
HETATM 7596 O O   . HOH   I 6 .   ? 0.96514   -27.84914 -29.30397 1.000 19.99515 ? 1116 HOH   A O   1 
HETATM 7597 O O   . HOH   I 6 .   ? -29.52864 23.85042  -16.18545 1.000 27.68630 ? 1117 HOH   A O   1 
HETATM 7598 O O   . HOH   I 6 .   ? -7.29357  -4.10903  -8.45279  1.000 25.60229 ? 1118 HOH   A O   1 
HETATM 7599 O O   . HOH   I 6 .   ? -19.48536 -22.85925 -3.24728  1.000 19.06140 ? 1119 HOH   A O   1 
HETATM 7600 O O   . HOH   I 6 .   ? -24.26501 -25.62636 -7.44238  1.000 29.97570 ? 1120 HOH   A O   1 
HETATM 7601 O O   . HOH   I 6 .   ? -1.61702  -12.02815 -18.32810 1.000 32.74852 ? 1121 HOH   A O   1 
HETATM 7602 O O   . HOH   I 6 .   ? -29.55546 9.55462   -25.16576 1.000 28.96306 ? 1122 HOH   A O   1 
HETATM 7603 O O   . HOH   I 6 .   ? -3.50251  5.21540   -18.47781 1.000 24.51740 ? 1123 HOH   A O   1 
HETATM 7604 O O   . HOH   I 6 .   ? -8.42546  14.63599  -22.23371 1.000 17.57956 ? 1124 HOH   A O   1 
HETATM 7605 O O   . HOH   I 6 .   ? -34.14457 -10.25998 -27.40183 1.000 29.83387 ? 1125 HOH   A O   1 
HETATM 7606 O O   . HOH   I 6 .   ? -4.94373  11.68473  -24.00144 1.000 32.93997 ? 1126 HOH   A O   1 
HETATM 7607 O O   . HOH   I 6 .   ? -25.34643 -18.90501 -3.94718  1.000 21.54942 ? 1127 HOH   A O   1 
HETATM 7608 O O   . HOH   I 6 .   ? -17.94435 10.95965  0.58651   1.000 11.90979 ? 1128 HOH   A O   1 
HETATM 7609 O O   . HOH   I 6 .   ? -5.94496  -17.81475 -49.10349 1.000 35.43224 ? 1129 HOH   A O   1 
HETATM 7610 O O   . HOH   I 6 .   ? -27.05813 -11.72884 -4.28014  1.000 38.11201 ? 1130 HOH   A O   1 
HETATM 7611 O O   . HOH   I 6 .   ? -22.58475 -5.46761  -27.74572 1.000 12.46919 ? 1131 HOH   A O   1 
HETATM 7612 O O   . HOH   I 6 .   ? 1.39127   -15.53454 -30.90378 1.000 30.53033 ? 1132 HOH   A O   1 
HETATM 7613 O O   . HOH   I 6 .   ? -8.87819  10.66887  1.36372   1.000 25.13853 ? 1133 HOH   A O   1 
HETATM 7614 O O   . HOH   I 6 .   ? -7.80580  11.02007  -35.00018 1.000 34.72287 ? 1134 HOH   A O   1 
HETATM 7615 O O   . HOH   I 6 .   ? -12.77134 -24.89975 -51.00976 1.000 32.98224 ? 1135 HOH   A O   1 
HETATM 7616 O O   . HOH   I 6 .   ? -11.59950 -19.93677 -16.35016 1.000 19.71145 ? 1136 HOH   A O   1 
HETATM 7617 O O   . HOH   I 6 .   ? -26.02579 -13.05080 -5.93838  1.000 32.32375 ? 1137 HOH   A O   1 
HETATM 7618 O O   . HOH   I 6 .   ? -4.88517  4.41628   -2.98458  1.000 23.16599 ? 1138 HOH   A O   1 
HETATM 7619 O O   . HOH   I 6 .   ? -7.62637  22.45930  -27.69225 1.000 34.44850 ? 1139 HOH   A O   1 
HETATM 7620 O O   . HOH   I 6 .   ? -6.29262  -19.59599 -45.77859 1.000 31.32360 ? 1140 HOH   A O   1 
HETATM 7621 O O   . HOH   I 6 .   ? -17.93243 -23.65956 -46.91271 1.000 33.27365 ? 1141 HOH   A O   1 
HETATM 7622 O O   . HOH   I 6 .   ? -29.97804 -4.82685  -33.09896 1.000 20.82280 ? 1142 HOH   A O   1 
HETATM 7623 O O   . HOH   I 6 .   ? -30.39708 -10.38215 -29.48405 1.000 25.90365 ? 1143 HOH   A O   1 
HETATM 7624 O O   . HOH   I 6 .   ? -24.80914 -19.81979 -42.85723 1.000 33.23604 ? 1144 HOH   A O   1 
HETATM 7625 O O   . HOH   I 6 .   ? -21.46841 -29.41924 -44.55425 1.000 29.68448 ? 1145 HOH   A O   1 
HETATM 7626 O O   . HOH   I 6 .   ? -26.61901 -18.82000 -27.96834 1.000 16.38688 ? 1146 HOH   A O   1 
HETATM 7627 O O   . HOH   I 6 .   ? -25.98371 -13.20245 -1.83485  1.000 35.40164 ? 1147 HOH   A O   1 
HETATM 7628 O O   . HOH   I 6 .   ? -14.03906 -11.23458 -44.89598 1.000 32.86119 ? 1148 HOH   A O   1 
HETATM 7629 O O   . HOH   I 6 .   ? -11.16993 23.54561  -17.47859 1.000 24.84948 ? 1149 HOH   A O   1 
HETATM 7630 O O   . HOH   I 6 .   ? -6.45049  19.60211  -0.78638  1.000 33.35890 ? 1150 HOH   A O   1 
HETATM 7631 O O   . HOH   I 6 .   ? -7.87642  -22.52953 -32.35349 1.000 18.91903 ? 1151 HOH   A O   1 
HETATM 7632 O O   . HOH   I 6 .   ? -9.51488  -27.22550 -24.66847 1.000 17.16477 ? 1152 HOH   A O   1 
HETATM 7633 O O   . HOH   I 6 .   ? -11.92340 -13.33223 -30.91820 1.000 22.66713 ? 1153 HOH   A O   1 
HETATM 7634 O O   . HOH   I 6 .   ? -11.69710 -13.42804 -27.70603 1.000 17.89699 ? 1154 HOH   A O   1 
HETATM 7635 O O   . HOH   I 6 .   ? -2.23587  -32.74129 -42.53470 1.000 23.59959 ? 1155 HOH   A O   1 
HETATM 7636 O O   . HOH   I 6 .   ? -22.47198 -8.07017  -26.60518 1.000 12.96219 ? 1156 HOH   A O   1 
HETATM 7637 O O   . HOH   I 6 .   ? -20.13486 -16.17733 -0.45270  1.000 23.46839 ? 1157 HOH   A O   1 
HETATM 7638 O O   . HOH   I 6 .   ? 0.16889   -37.18923 -14.04074 1.000 38.24599 ? 1158 HOH   A O   1 
HETATM 7639 O O   . HOH   I 6 .   ? -11.23941 -22.32595 -9.31003  1.000 30.77730 ? 1159 HOH   A O   1 
HETATM 7640 O O   . HOH   I 6 .   ? -21.53755 -13.35191 -23.50284 1.000 12.96237 ? 1160 HOH   A O   1 
HETATM 7641 O O   . HOH   I 6 .   ? -10.56279 -24.96593 -29.26097 1.000 16.86122 ? 1161 HOH   A O   1 
HETATM 7642 O O   . HOH   I 6 .   ? -14.06524 -12.29852 -7.84539  1.000 31.90639 ? 1162 HOH   A O   1 
HETATM 7643 O O   . HOH   I 6 .   ? -11.42210 -7.88368  -22.69564 1.000 23.38103 ? 1163 HOH   A O   1 
HETATM 7644 O O   . HOH   I 6 .   ? -22.26840 -5.18478  -44.62576 1.000 34.51985 ? 1164 HOH   A O   1 
HETATM 7645 O O   . HOH   I 6 .   ? 3.35425   -12.47452 -47.04338 1.000 31.55962 ? 1165 HOH   A O   1 
HETATM 7646 O O   . HOH   I 6 .   ? -24.48284 -39.35209 -17.65819 1.000 42.86120 ? 1166 HOH   A O   1 
HETATM 7647 O O   . HOH   I 6 .   ? -27.69610 -16.60872 -33.72625 1.000 18.88787 ? 1167 HOH   A O   1 
HETATM 7648 O O   . HOH   I 6 .   ? 5.45580   -26.73768 -36.01244 1.000 19.87668 ? 1168 HOH   A O   1 
HETATM 7649 O O   . HOH   I 6 .   ? -25.83546 -32.63685 -24.79028 1.000 32.46621 ? 1169 HOH   A O   1 
HETATM 7650 O O   . HOH   I 6 .   ? -0.16016  -36.05879 -20.44482 1.000 27.78649 ? 1170 HOH   A O   1 
HETATM 7651 O O   . HOH   I 6 .   ? -1.18558  -9.45297  -47.31459 1.000 35.62725 ? 1171 HOH   A O   1 
HETATM 7652 O O   . HOH   I 6 .   ? -15.35276 -36.54359 -29.15409 1.000 27.97850 ? 1172 HOH   A O   1 
HETATM 7653 O O   . HOH   I 6 .   ? -8.77374  27.56403  -30.76749 1.000 32.64331 ? 1173 HOH   A O   1 
HETATM 7654 O O   . HOH   I 6 .   ? -24.76980 4.84534   -26.49375 1.000 19.11599 ? 1174 HOH   A O   1 
HETATM 7655 O O   . HOH   I 6 .   ? -15.80805 -1.36503  1.56899   1.000 27.89931 ? 1175 HOH   A O   1 
HETATM 7656 O O   . HOH   I 6 .   ? -13.49543 -2.37112  -28.28892 1.000 24.46370 ? 1176 HOH   A O   1 
HETATM 7657 O O   . HOH   I 6 .   ? 8.22421   -7.78226  -54.75225 1.000 30.22245 ? 1177 HOH   A O   1 
HETATM 7658 O O   . HOH   I 6 .   ? -9.08716  -18.54399 -20.19587 1.000 11.61962 ? 1178 HOH   A O   1 
HETATM 7659 O O   . HOH   I 6 .   ? -26.99925 0.01772   -17.89778 1.000 26.17485 ? 1179 HOH   A O   1 
HETATM 7660 O O   . HOH   I 6 .   ? -18.56360 10.50366  -36.23820 1.000 39.62925 ? 1180 HOH   A O   1 
HETATM 7661 O O   . HOH   I 6 .   ? -2.25083  -7.68168  -38.41986 1.000 30.24108 ? 1181 HOH   A O   1 
HETATM 7662 O O   . HOH   I 6 .   ? -7.35282  -33.02484 -8.33851  1.000 31.15575 ? 1182 HOH   A O   1 
HETATM 7663 O O   . HOH   I 6 .   ? -13.67406 22.72009  -23.73733 1.000 28.01710 ? 1183 HOH   A O   1 
HETATM 7664 O O   . HOH   I 6 .   ? -0.71320  10.49007  -11.32388 1.000 19.57241 ? 1184 HOH   A O   1 
HETATM 7665 O O   . HOH   I 6 .   ? -7.40181  5.01343   -2.05966  1.000 37.95689 ? 1185 HOH   A O   1 
HETATM 7666 O O   . HOH   I 6 .   ? -2.06032  -13.24550 -42.57260 1.000 22.67009 ? 1186 HOH   A O   1 
HETATM 7667 O O   . HOH   I 6 .   ? -30.02963 -3.20178  -27.62754 1.000 28.11549 ? 1187 HOH   A O   1 
HETATM 7668 O O   . HOH   I 6 .   ? -12.19996 24.69443  -3.81547  1.000 26.17934 ? 1188 HOH   A O   1 
HETATM 7669 O O   . HOH   I 6 .   ? 9.241     -9.420    -68.052   1.000 37.35359 ? 1189 HOH   A O   1 
HETATM 7670 O O   . HOH   I 6 .   ? -6.81287  -28.80100 -7.80354  1.000 26.99845 ? 1190 HOH   A O   1 
HETATM 7671 O O   . HOH   I 6 .   ? -22.09027 -14.36319 -44.86662 1.000 26.66646 ? 1191 HOH   A O   1 
HETATM 7672 O O   . HOH   I 6 .   ? -2.85437  -24.29307 -31.74820 1.000 18.07013 ? 1192 HOH   A O   1 
HETATM 7673 O O   . HOH   I 6 .   ? -17.88061 -1.94313  -41.19008 1.000 24.46821 ? 1193 HOH   A O   1 
HETATM 7674 O O   . HOH   I 6 .   ? -1.338    -6.786    -49.101   1.000 34.87428 ? 1194 HOH   A O   1 
HETATM 7675 O O   . HOH   I 6 .   ? 2.16095   -34.89611 -26.24488 1.000 28.44077 ? 1195 HOH   A O   1 
HETATM 7676 O O   . HOH   I 6 .   ? -7.452    7.984     1.622     1.000 27.99186 ? 1196 HOH   A O   1 
HETATM 7677 O O   . HOH   I 6 .   ? -5.21470  -18.21864 -27.15939 1.000 13.11415 ? 1197 HOH   A O   1 
HETATM 7678 O O   . HOH   I 6 .   ? -22.45671 -35.90452 -24.72209 1.000 39.61643 ? 1198 HOH   A O   1 
HETATM 7679 O O   . HOH   I 6 .   ? -35.00263 -14.96378 -19.65474 1.000 30.75493 ? 1199 HOH   A O   1 
HETATM 7680 O O   . HOH   I 6 .   ? -22.40447 0.02182   -37.86130 1.000 20.81424 ? 1200 HOH   A O   1 
HETATM 7681 O O   . HOH   I 6 .   ? -0.54598  14.70334  -28.01617 1.000 38.85085 ? 1201 HOH   A O   1 
HETATM 7682 O O   . HOH   I 6 .   ? -23.08733 20.88585  -27.94229 1.000 34.17669 ? 1202 HOH   A O   1 
HETATM 7683 O O   . HOH   I 6 .   ? -9.26768  -11.32742 -42.47464 1.000 21.57030 ? 1203 HOH   A O   1 
HETATM 7684 O O   . HOH   I 6 .   ? -29.27281 3.34494   -10.33800 1.000 37.29741 ? 1204 HOH   A O   1 
HETATM 7685 O O   . HOH   I 6 .   ? 0.64591   -26.62007 -27.09122 1.000 20.36893 ? 1205 HOH   A O   1 
HETATM 7686 O O   . HOH   I 6 .   ? 0.68342   -24.11737 -28.68656 1.000 23.75739 ? 1206 HOH   A O   1 
HETATM 7687 O O   . HOH   I 6 .   ? -27.77759 -3.15972  -40.36259 1.000 27.24306 ? 1207 HOH   A O   1 
HETATM 7688 O O   . HOH   I 6 .   ? -15.33525 -30.23807 -45.64955 1.000 29.64008 ? 1208 HOH   A O   1 
HETATM 7689 O O   . HOH   I 6 .   ? 4.64722   -12.48281 -39.41897 1.000 37.37428 ? 1209 HOH   A O   1 
HETATM 7690 O O   . HOH   I 6 .   ? 6.43729   -18.63948 -36.04128 1.000 33.08550 ? 1210 HOH   A O   1 
HETATM 7691 O O   . HOH   I 6 .   ? -10.13972 -22.75262 -30.66964 1.000 12.76344 ? 1211 HOH   A O   1 
HETATM 7692 O O   . HOH   I 6 .   ? -27.52692 -19.68371 -20.69210 1.000 31.82877 ? 1212 HOH   A O   1 
HETATM 7693 O O   . HOH   I 6 .   ? -17.90116 27.88710  -8.82114  1.000 33.87284 ? 1213 HOH   A O   1 
HETATM 7694 O O   . HOH   I 6 .   ? -3.36246  6.04890   -4.14322  1.000 19.46687 ? 1214 HOH   A O   1 
HETATM 7695 O O   . HOH   I 6 .   ? -8.41034  -20.79008 -47.29144 1.000 27.16303 ? 1215 HOH   A O   1 
HETATM 7696 O O   . HOH   I 6 .   ? -29.64104 -30.53114 -11.68796 1.000 25.26723 ? 1216 HOH   A O   1 
HETATM 7697 O O   . HOH   I 6 .   ? -9.79548  24.75137  -13.14405 1.000 23.80073 ? 1217 HOH   A O   1 
HETATM 7698 O O   . HOH   I 6 .   ? -8.42185  27.86686  -14.77887 1.000 36.87173 ? 1218 HOH   A O   1 
HETATM 7699 O O   . HOH   I 6 .   ? -6.36337  20.23958  -26.48585 1.000 20.04841 ? 1219 HOH   A O   1 
HETATM 7700 O O   . HOH   I 6 .   ? -1.19428  -37.61783 -26.68668 1.000 24.58885 ? 1220 HOH   A O   1 
HETATM 7701 O O   . HOH   I 6 .   ? -15.04772 6.15836   0.45558   1.000 23.39306 ? 1221 HOH   A O   1 
HETATM 7702 O O   . HOH   I 6 .   ? -27.57093 -26.78263 -21.60279 1.000 31.80621 ? 1222 HOH   A O   1 
HETATM 7703 O O   . HOH   I 6 .   ? -16.86059 -23.81743 -1.50720  1.000 32.58066 ? 1223 HOH   A O   1 
HETATM 7704 O O   . HOH   I 6 .   ? -24.99770 22.63635  -25.82061 1.000 43.37386 ? 1224 HOH   A O   1 
HETATM 7705 O O   . HOH   I 6 .   ? -29.073   8.118     -20.485   1.000 26.70191 ? 1225 HOH   A O   1 
HETATM 7706 O O   . HOH   I 6 .   ? -8.73891  20.50272  -14.62161 1.000 22.35772 ? 1226 HOH   A O   1 
HETATM 7707 O O   . HOH   I 6 .   ? -4.99691  2.23474   -9.81898  1.000 17.33194 ? 1227 HOH   A O   1 
HETATM 7708 O O   . HOH   I 6 .   ? -31.91060 -29.79825 -10.17472 1.000 38.91209 ? 1228 HOH   A O   1 
HETATM 7709 O O   . HOH   I 6 .   ? -5.77040  14.49592  -22.78097 1.000 28.66692 ? 1229 HOH   A O   1 
HETATM 7710 O O   . HOH   I 6 .   ? -9.58356  -14.52272 -19.88900 1.000 37.73752 ? 1230 HOH   A O   1 
HETATM 7711 O O   . HOH   I 6 .   ? -13.41351 26.50543  -17.48091 1.000 35.63275 ? 1231 HOH   A O   1 
HETATM 7712 O O   . HOH   I 6 .   ? -29.41869 -15.66215 -16.28690 1.000 29.00050 ? 1232 HOH   A O   1 
HETATM 7713 O O   . HOH   I 6 .   ? -25.63983 12.40240  -31.30160 1.000 41.84562 ? 1233 HOH   A O   1 
HETATM 7714 O O   . HOH   I 6 .   ? -5.37093  -17.44383 -15.87057 1.000 32.64621 ? 1234 HOH   A O   1 
HETATM 7715 O O   . HOH   I 6 .   ? -7.21518  -36.45916 -46.32430 1.000 31.82705 ? 1235 HOH   A O   1 
HETATM 7716 O O   . HOH   I 6 .   ? -11.67304 -32.14587 -8.74176  1.000 31.52912 ? 1236 HOH   A O   1 
HETATM 7717 O O   . HOH   I 6 .   ? -1.99930  -38.56950 -45.62924 1.000 35.68268 ? 1237 HOH   A O   1 
HETATM 7718 O O   . HOH   I 6 .   ? -11.34680 -21.83614 -1.56603  1.000 36.12865 ? 1238 HOH   A O   1 
HETATM 7719 O O   . HOH   I 6 .   ? -4.97304  -38.63159 -45.15590 1.000 26.36933 ? 1239 HOH   A O   1 
HETATM 7720 O O   . HOH   I 6 .   ? -29.01674 0.03649   -20.93306 1.000 39.53780 ? 1240 HOH   A O   1 
HETATM 7721 O O   . HOH   I 6 .   ? -21.40367 -41.80577 -40.78904 1.000 37.23298 ? 1241 HOH   A O   1 
HETATM 7722 O O   . HOH   I 6 .   ? -14.33905 -38.11519 -7.42894  1.000 26.75459 ? 1242 HOH   A O   1 
HETATM 7723 O O   . HOH   I 6 .   ? -28.64433 -20.64753 -28.19566 1.000 28.51634 ? 1243 HOH   A O   1 
HETATM 7724 O O   . HOH   I 6 .   ? -26.72825 13.61828  -5.11469  1.000 14.02800 ? 1244 HOH   A O   1 
HETATM 7725 O O   . HOH   I 6 .   ? -3.01587  -13.13506 -27.60416 1.000 27.32033 ? 1245 HOH   A O   1 
HETATM 7726 O O   . HOH   I 6 .   ? 4.51723   -18.86452 -31.34739 1.000 32.03766 ? 1246 HOH   A O   1 
HETATM 7727 O O   . HOH   I 6 .   ? -8.23601  5.59993   -27.32976 1.000 36.15342 ? 1247 HOH   A O   1 
HETATM 7728 O O   . HOH   I 6 .   ? -28.03732 -11.52597 -41.90422 1.000 26.70703 ? 1248 HOH   A O   1 
HETATM 7729 O O   . HOH   I 6 .   ? -27.10908 -29.69480 -26.00244 1.000 32.21342 ? 1249 HOH   A O   1 
HETATM 7730 O O   . HOH   I 6 .   ? -11.59094 22.80268  -22.10782 1.000 31.90132 ? 1250 HOH   A O   1 
HETATM 7731 O O   . HOH   I 6 .   ? -11.37396 -10.27592 -21.23908 1.000 28.61980 ? 1251 HOH   A O   1 
HETATM 7732 O O   . HOH   I 6 .   ? -27.26486 19.06964  -8.46947  1.000 26.20882 ? 1252 HOH   A O   1 
HETATM 7733 O O   . HOH   I 6 .   ? -30.46826 -15.79565 -37.24622 1.000 29.92442 ? 1253 HOH   A O   1 
HETATM 7734 O O   . HOH   I 6 .   ? 1.57338   -18.70116 -15.34581 1.000 34.30126 ? 1254 HOH   A O   1 
HETATM 7735 O O   . HOH   I 6 .   ? -16.63381 -5.84162  2.21603   1.000 37.28213 ? 1255 HOH   A O   1 
HETATM 7736 O O   . HOH   I 6 .   ? -24.13818 -23.70848 -0.64701  1.000 32.19852 ? 1256 HOH   A O   1 
HETATM 7737 O O   . HOH   I 6 .   ? -20.58831 -9.08271  -24.48172 1.000 15.91566 ? 1257 HOH   A O   1 
HETATM 7738 O O   . HOH   I 6 .   ? -1.99598  -14.18747 -24.80935 1.000 28.54607 ? 1258 HOH   A O   1 
HETATM 7739 O O   . HOH   I 6 .   ? -31.83694 24.89201  -11.02477 1.000 31.07450 ? 1259 HOH   A O   1 
HETATM 7740 O O   . HOH   I 6 .   ? -5.59901  22.02494  -6.54280  1.000 29.58779 ? 1260 HOH   A O   1 
HETATM 7741 O O   . HOH   I 6 .   ? -20.67975 -43.77611 -39.90849 1.000 42.00515 ? 1261 HOH   A O   1 
HETATM 7742 O O   . HOH   I 6 .   ? -20.91076 13.42161  -30.48357 1.000 21.29794 ? 1262 HOH   A O   1 
HETATM 7743 O O   . HOH   I 6 .   ? -8.83951  22.87057  -0.52008  1.000 37.08367 ? 1263 HOH   A O   1 
HETATM 7744 O O   . HOH   I 6 .   ? -10.61727 7.08098   -27.70564 1.000 28.35544 ? 1264 HOH   A O   1 
HETATM 7745 O O   . HOH   I 6 .   ? -14.04783 13.83856  -32.13094 1.000 30.87584 ? 1265 HOH   A O   1 
HETATM 7746 O O   . HOH   I 6 .   ? -2.50226  -35.26759 -23.33845 1.000 24.59227 ? 1266 HOH   A O   1 
HETATM 7747 O O   . HOH   I 6 .   ? -11.75162 -7.36979  -35.08781 1.000 33.79052 ? 1267 HOH   A O   1 
HETATM 7748 O O   . HOH   I 6 .   ? -17.17175 16.39266  -30.54567 1.000 25.02562 ? 1268 HOH   A O   1 
HETATM 7749 O O   . HOH   I 6 .   ? -25.37118 10.00783  -11.84389 1.000 29.02462 ? 1269 HOH   A O   1 
HETATM 7750 O O   . HOH   I 6 .   ? -8.03079  -16.90480 -15.39202 1.000 38.00942 ? 1270 HOH   A O   1 
HETATM 7751 O O   . HOH   I 6 .   ? -18.06205 -26.26067 -2.33537  1.000 20.76991 ? 1271 HOH   A O   1 
HETATM 7752 O O   . HOH   I 6 .   ? -6.57467  18.66273  -28.32996 1.000 21.75547 ? 1272 HOH   A O   1 
HETATM 7753 O O   . HOH   I 6 .   ? -4.34142  -0.46165  -10.26174 1.000 27.63605 ? 1273 HOH   A O   1 
HETATM 7754 O O   . HOH   I 6 .   ? -9.79360  22.68832  -26.96998 1.000 40.19513 ? 1274 HOH   A O   1 
HETATM 7755 O O   . HOH   I 6 .   ? -2.64371  17.30798  -4.69225  1.000 28.65929 ? 1275 HOH   A O   1 
HETATM 7756 O O   . HOH   I 6 .   ? -22.67682 -20.25130 -0.78470  1.000 30.35074 ? 1276 HOH   A O   1 
HETATM 7757 O O   . HOH   I 6 .   ? -13.15909 -4.19291  2.81925   1.000 42.01618 ? 1277 HOH   A O   1 
HETATM 7758 O O   . HOH   I 6 .   ? -4.70462  -17.08083 -22.70008 1.000 29.23464 ? 1278 HOH   A O   1 
HETATM 7759 O O   . HOH   I 6 .   ? 5.26969   -20.95206 -14.90157 1.000 34.41471 ? 1279 HOH   A O   1 
HETATM 7760 O O   . HOH   I 6 .   ? -31.28793 -5.69341  -31.02722 1.000 27.13992 ? 1280 HOH   A O   1 
HETATM 7761 O O   . HOH   I 6 .   ? -12.54874 -9.37696  -33.40291 1.000 23.10104 ? 1281 HOH   A O   1 
HETATM 7762 O O   . HOH   I 6 .   ? -24.11107 24.32857  -10.54101 1.000 30.19817 ? 1282 HOH   A O   1 
HETATM 7763 O O   . HOH   I 6 .   ? -2.06273  3.32707   -23.51734 1.000 37.15728 ? 1283 HOH   A O   1 
HETATM 7764 O O   . HOH   I 6 .   ? -22.88332 -18.36951 -43.61373 1.000 33.75029 ? 1284 HOH   A O   1 
HETATM 7765 O O   . HOH   I 6 .   ? -20.90110 5.66874   -37.26092 1.000 37.38913 ? 1285 HOH   A O   1 
HETATM 7766 O O   . HOH   I 6 .   ? -11.52431 1.93963   -28.42718 1.000 29.43895 ? 1286 HOH   A O   1 
HETATM 7767 O O   . HOH   I 6 .   ? -5.57129  1.02232   -1.44775  1.000 36.18053 ? 1287 HOH   A O   1 
HETATM 7768 O O   . HOH   I 6 .   ? -1.43943  -38.44610 -16.87684 1.000 33.49915 ? 1288 HOH   A O   1 
HETATM 7769 O O   . HOH   I 6 .   ? -28.93311 2.13562   -17.69699 1.000 35.24153 ? 1289 HOH   A O   1 
HETATM 7770 O O   . HOH   I 6 .   ? -12.16430 -1.95378  3.96363   1.000 35.35852 ? 1290 HOH   A O   1 
HETATM 7771 O O   . HOH   I 6 .   ? -28.77981 0.29666   -23.46303 1.000 37.08693 ? 1291 HOH   A O   1 
HETATM 7772 O O   . HOH   I 6 .   ? -11.823   -27.433   -0.813    1.000 30.30573 ? 1292 HOH   A O   1 
HETATM 7773 O O   . HOH   I 6 .   ? -11.58795 -4.24445  -31.88233 1.000 35.29753 ? 1293 HOH   A O   1 
HETATM 7774 O O   . HOH   I 6 .   ? -5.36680  18.01626  -15.73017 1.000 24.48177 ? 1294 HOH   A O   1 
HETATM 7775 O O   . HOH   I 6 .   ? -20.136   -26.265   -1.050    1.000 33.76154 ? 1295 HOH   A O   1 
HETATM 7776 O O   . HOH   I 6 .   ? -8.23161  -30.30449 -5.85272  1.000 29.39568 ? 1296 HOH   A O   1 
HETATM 7777 O O   . HOH   I 6 .   ? -8.37333  -16.46998 -23.69137 1.000 23.84955 ? 1297 HOH   A O   1 
HETATM 7778 O O   . HOH   I 6 .   ? -30.67506 -7.45156  -39.08745 1.000 38.05181 ? 1298 HOH   A O   1 
HETATM 7779 O O   . HOH   I 6 .   ? -16.33222 -3.33151  3.62207   1.000 43.56643 ? 1299 HOH   A O   1 
HETATM 7780 O O   . HOH   I 6 .   ? -13.69926 -1.63785  -23.09130 1.000 28.12303 ? 1300 HOH   A O   1 
HETATM 7781 O O   . HOH   I 6 .   ? -7.16510  -17.51058 -46.89302 1.000 30.32642 ? 1301 HOH   A O   1 
HETATM 7782 O O   . HOH   I 6 .   ? -28.10083 -27.70036 -39.46800 1.000 33.53712 ? 1302 HOH   A O   1 
HETATM 7783 O O   . HOH   I 6 .   ? -12.205   -4.405    -47.551   1.000 41.25502 ? 1303 HOH   A O   1 
HETATM 7784 O O   . HOH   I 6 .   ? -16.84257 20.73174  -32.78895 1.000 31.18014 ? 1304 HOH   A O   1 
HETATM 7785 O O   . HOH   I 6 .   ? -28.70874 -12.38553 -45.04000 1.000 37.16906 ? 1305 HOH   A O   1 
HETATM 7786 O O   . HOH   I 6 .   ? -29.79981 -4.95843  -40.28859 1.000 35.32660 ? 1306 HOH   A O   1 
HETATM 7787 O O   . HOH   I 6 .   ? -26.71894 -13.06006 -46.33020 1.000 36.74572 ? 1307 HOH   A O   1 
HETATM 7788 O O   . HOH   I 6 .   ? -8.44087  -15.35584 -27.74736 1.000 20.52236 ? 1308 HOH   A O   1 
HETATM 7789 O O   . HOH   I 6 .   ? -8.63774  -12.81442 -30.11099 1.000 23.39128 ? 1309 HOH   A O   1 
HETATM 7790 O O   . HOH   I 6 .   ? -12.40593 -24.20755 -27.18231 1.000 14.28630 ? 1310 HOH   A O   1 
HETATM 7791 O O   . HOH   I 6 .   ? -10.64360 -0.25139  -23.90407 1.000 36.96986 ? 1311 HOH   A O   1 
HETATM 7792 O O   . HOH   I 6 .   ? -7.528    -14.485   -45.911   1.000 22.26476 ? 1312 HOH   A O   1 
HETATM 7793 O O   . HOH   I 6 .   ? -27.66841 0.85154   -25.37148 1.000 23.57084 ? 1313 HOH   A O   1 
HETATM 7794 O O   . HOH   I 6 .   ? -26.94541 -16.66943 -4.03428  1.000 31.34202 ? 1314 HOH   A O   1 
HETATM 7795 O O   . HOH   I 6 .   ? -25.36621 -20.32037 -1.27631  1.000 33.75236 ? 1315 HOH   A O   1 
HETATM 7796 O O   . HOH   I 6 .   ? -36.085   -11.710   -28.317   1.000 32.89994 ? 1316 HOH   A O   1 
HETATM 7797 O O   . HOH   I 6 .   ? -10.97743 -6.44362  -28.45595 1.000 32.89459 ? 1317 HOH   A O   1 
HETATM 7798 O O   . HOH   I 6 .   ? -5.64348  -5.10280  -10.20323 1.000 32.97167 ? 1318 HOH   A O   1 
HETATM 7799 O O   . HOH   I 6 .   ? -31.443   -0.410    -31.438   1.000 29.00470 ? 1319 HOH   A O   1 
HETATM 7800 O O   . HOH   I 6 .   ? -31.77997 -3.28458  -26.14538 1.000 35.25778 ? 1320 HOH   A O   1 
HETATM 7801 O O   . HOH   I 6 .   ? -7.20718  -13.66819 -25.89339 1.000 41.44123 ? 1321 HOH   A O   1 
HETATM 7802 O O   . HOH   I 6 .   ? 0.14143   -36.63624 -11.39319 1.000 39.85899 ? 1322 HOH   A O   1 
HETATM 7803 O O   . HOH   I 6 .   ? -30.22041 -1.95597  -33.82586 1.000 24.17148 ? 1323 HOH   A O   1 
HETATM 7804 O O   . HOH   I 6 .   ? -8.67312  -11.05349 -32.66632 1.000 27.43596 ? 1324 HOH   A O   1 
HETATM 7805 O O   . HOH   I 6 .   ? -12.57764 1.11588   -25.86291 1.000 23.55272 ? 1325 HOH   A O   1 
HETATM 7806 O O   . HOH   I 6 .   ? -25.84529 -25.11458 -41.85332 1.000 32.50129 ? 1326 HOH   A O   1 
HETATM 7807 O O   . HOH   I 6 .   ? -8.790    20.320    0.353     1.000 24.47247 ? 1327 HOH   A O   1 
HETATM 7808 O O   . HOH   I 6 .   ? -23.89917 -43.13271 -11.66648 1.000 34.15250 ? 1328 HOH   A O   1 
HETATM 7809 O O   . HOH   I 6 .   ? -26.348   14.592    -2.483    1.000 36.08968 ? 1329 HOH   A O   1 
HETATM 7810 O O   . HOH   I 6 .   ? -10.94646 -8.86701  -29.44338 1.000 27.59337 ? 1330 HOH   A O   1 
HETATM 7811 O O   . HOH   I 6 .   ? -4.41396  2.52645   -19.42386 1.000 30.95791 ? 1331 HOH   A O   1 
HETATM 7812 O O   . HOH   I 6 .   ? -19.33734 -19.03994 -45.39547 1.000 26.99655 ? 1332 HOH   A O   1 
HETATM 7813 O O   . HOH   I 6 .   ? -19.75499 -15.21850 -44.42228 1.000 28.59341 ? 1333 HOH   A O   1 
HETATM 7814 O O   . HOH   I 6 .   ? -32.39461 -8.03077  -30.74324 1.000 32.78348 ? 1334 HOH   A O   1 
HETATM 7815 O O   . HOH   I 6 .   ? -10.46440 -11.20848 -28.35593 1.000 25.63872 ? 1335 HOH   A O   1 
HETATM 7816 O O   . HOH   I 6 .   ? -4.88728  -14.34766 -18.49271 1.000 42.99117 ? 1336 HOH   A O   1 
HETATM 7817 O O   . HOH   I 6 .   ? -8.80054  -10.16967 -26.61280 1.000 38.29334 ? 1337 HOH   A O   1 
HETATM 7818 O O   . HOH   I 6 .   ? -9.24867  -8.64106  -31.31547 1.000 36.98494 ? 1338 HOH   A O   1 
HETATM 7819 O O   . HOH   J 6 .   ? 5.94433   5.64265   -18.86576 1.000 29.66627 ? 701  HOH   B O   1 
HETATM 7820 O O   . HOH   J 6 .   ? 10.54523  17.74799  -26.14399 1.000 30.66610 ? 702  HOH   B O   1 
HETATM 7821 O O   . HOH   J 6 .   ? 0.22342   -16.45869 1.24799   1.000 31.78474 ? 703  HOH   B O   1 
HETATM 7822 O O   . HOH   J 6 .   ? -8.50401  3.16368   -60.70777 1.000 28.08752 ? 704  HOH   B O   1 
HETATM 7823 O O   . HOH   J 6 .   ? 11.76457  39.05074  -25.84738 1.000 28.41917 ? 705  HOH   B O   1 
HETATM 7824 O O   . HOH   J 6 .   ? 1.18932   48.05223  -14.24351 1.000 33.81674 ? 706  HOH   B O   1 
HETATM 7825 O O   . HOH   J 6 .   ? 20.80822  35.73512  -14.50543 1.000 28.08961 ? 707  HOH   B O   1 
HETATM 7826 O O   . HOH   J 6 .   ? 13.751    -3.411    6.319     1.000 31.48960 ? 708  HOH   B O   1 
HETATM 7827 O O   . HOH   J 6 .   ? 22.29323  -6.36768  -24.15684 1.000 33.25954 ? 709  HOH   B O   1 
HETATM 7828 O O   . HOH   J 6 .   ? 9.77948   13.07594  -28.08588 1.000 29.85953 ? 710  HOH   B O   1 
HETATM 7829 O O   . HOH   J 6 .   ? -6.76620  20.78376  -34.67345 1.000 17.70628 ? 711  HOH   B O   1 
HETATM 7830 O O   . HOH   J 6 .   ? 13.32312  -9.68731  -27.68719 1.000 28.80547 ? 712  HOH   B O   1 
HETATM 7831 O O   . HOH   J 6 .   ? 20.51652  9.38623   -40.27510 1.000 32.65159 ? 713  HOH   B O   1 
HETATM 7832 O O   . HOH   J 6 .   ? -4.41666  16.38820  -11.17766 1.000 26.51757 ? 714  HOH   B O   1 
HETATM 7833 O O   . HOH   J 6 .   ? -9.06073  20.94109  -42.77440 1.000 39.91910 ? 715  HOH   B O   1 
HETATM 7834 O O   . HOH   J 6 .   ? 21.52033  31.90143  -17.88765 1.000 26.01756 ? 716  HOH   B O   1 
HETATM 7835 O O   . HOH   J 6 .   ? 15.10992  14.02326  -41.60582 1.000 38.75293 ? 717  HOH   B O   1 
HETATM 7836 O O   . HOH   J 6 .   ? 22.41693  15.58418  -4.62653  1.000 37.67518 ? 718  HOH   B O   1 
HETATM 7837 O O   . HOH   J 6 .   ? -1.74190  8.83194   -64.36647 1.000 24.72025 ? 719  HOH   B O   1 
HETATM 7838 O O   . HOH   J 6 .   ? 4.25902   11.29709  -35.18279 1.000 28.83644 ? 720  HOH   B O   1 
HETATM 7839 O O   . HOH   J 6 .   ? 3.14215   32.69796  -2.42572  1.000 26.97472 ? 721  HOH   B O   1 
HETATM 7840 O O   . HOH   J 6 .   ? 11.58782  40.47057  -48.11358 1.000 43.71167 ? 722  HOH   B O   1 
HETATM 7841 O O   . HOH   J 6 .   ? -7.17150  40.71906  -16.81277 1.000 29.03954 ? 723  HOH   B O   1 
HETATM 7842 O O   . HOH   J 6 .   ? 20.50441  2.71680   -19.07689 1.000 26.36306 ? 724  HOH   B O   1 
HETATM 7843 O O   . HOH   J 6 .   ? 12.12438  6.80964   -26.33108 1.000 20.28073 ? 725  HOH   B O   1 
HETATM 7844 O O   . HOH   J 6 .   ? 14.60169  30.13555  -47.37245 1.000 40.10019 ? 726  HOH   B O   1 
HETATM 7845 O O   . HOH   J 6 .   ? -6.16401  11.69341  -56.10003 1.000 27.80117 ? 727  HOH   B O   1 
HETATM 7846 O O   . HOH   J 6 .   ? 1.47375   -14.40757 -24.36515 1.000 31.01740 ? 728  HOH   B O   1 
HETATM 7847 O O   . HOH   J 6 .   ? 3.77721   -14.69994 -13.74696 1.000 26.95818 ? 729  HOH   B O   1 
HETATM 7848 O O   . HOH   J 6 .   ? 5.60949   35.63601  -9.76502  1.000 14.05120 ? 730  HOH   B O   1 
HETATM 7849 O O   . HOH   J 6 .   ? 26.56602  24.67731  -22.69997 1.000 36.64391 ? 731  HOH   B O   1 
HETATM 7850 O O   . HOH   J 6 .   ? 1.49946   -15.72569 -26.20049 1.000 28.38707 ? 732  HOH   B O   1 
HETATM 7851 O O   . HOH   J 6 .   ? 7.55191   16.39879  -31.49128 1.000 20.61690 ? 733  HOH   B O   1 
HETATM 7852 O O   . HOH   J 6 .   ? 9.72114   13.49237  -5.55083  1.000 12.18295 ? 734  HOH   B O   1 
HETATM 7853 O O   . HOH   J 6 .   ? -10.63377 17.30651  -57.46054 1.000 40.89483 ? 735  HOH   B O   1 
HETATM 7854 O O   . HOH   J 6 .   ? 6.45009   19.25161  -27.97787 1.000 7.25945  ? 736  HOH   B O   1 
HETATM 7855 O O   . HOH   J 6 .   ? 17.04794  30.29538  -5.10906  1.000 23.18162 ? 737  HOH   B O   1 
HETATM 7856 O O   . HOH   J 6 .   ? 3.77007   22.46426  -26.24023 1.000 12.74859 ? 738  HOH   B O   1 
HETATM 7857 O O   . HOH   J 6 .   ? 22.23512  36.48178  -18.61755 1.000 26.36103 ? 739  HOH   B O   1 
HETATM 7858 O O   . HOH   J 6 .   ? 10.30471  14.49733  -26.39653 1.000 26.22892 ? 740  HOH   B O   1 
HETATM 7859 O O   . HOH   J 6 .   ? -8.56971  7.51452   -54.38495 1.000 37.68046 ? 741  HOH   B O   1 
HETATM 7860 O O   . HOH   J 6 .   ? 8.99863   9.53777   -26.43450 1.000 28.06957 ? 742  HOH   B O   1 
HETATM 7861 O O   . HOH   J 6 .   ? -0.42052  23.56127  -18.01749 1.000 19.96233 ? 743  HOH   B O   1 
HETATM 7862 O O   . HOH   J 6 .   ? 11.17256  17.48984  -12.43379 1.000 12.94678 ? 744  HOH   B O   1 
HETATM 7863 O O   . HOH   J 6 .   ? 3.61295   -3.09126  -9.80592  1.000 14.18025 ? 745  HOH   B O   1 
HETATM 7864 O O   . HOH   J 6 .   ? -7.11385  24.16239  -15.89710 1.000 24.92492 ? 746  HOH   B O   1 
HETATM 7865 O O   . HOH   J 6 .   ? 19.43735  9.34662   -37.40043 1.000 24.61023 ? 747  HOH   B O   1 
HETATM 7866 O O   . HOH   J 6 .   ? 27.69231  28.04820  -31.36616 1.000 35.75109 ? 748  HOH   B O   1 
HETATM 7867 O O   . HOH   J 6 .   ? 0.49570   38.39071  -7.92786  1.000 34.45700 ? 749  HOH   B O   1 
HETATM 7868 O O   . HOH   J 6 .   ? 21.65070  18.12977  -6.25370  1.000 23.57549 ? 750  HOH   B O   1 
HETATM 7869 O O   . HOH   J 6 .   ? -0.18542  47.23960  -20.39610 1.000 29.52801 ? 751  HOH   B O   1 
HETATM 7870 O O   . HOH   J 6 .   ? 6.02001   46.23255  -7.46765  1.000 30.12054 ? 752  HOH   B O   1 
HETATM 7871 O O   . HOH   J 6 .   ? 13.30839  -18.26232 -15.88248 1.000 16.58943 ? 753  HOH   B O   1 
HETATM 7872 O O   . HOH   J 6 .   ? 25.76657  20.92338  -39.81055 1.000 40.13769 ? 754  HOH   B O   1 
HETATM 7873 O O   . HOH   J 6 .   ? -0.28694  14.56540  -41.15225 1.000 26.20331 ? 755  HOH   B O   1 
HETATM 7874 O O   . HOH   J 6 .   ? 3.87938   28.01738  -8.06260  1.000 18.93732 ? 756  HOH   B O   1 
HETATM 7875 O O   . HOH   J 6 .   ? 6.62571   29.39021  -27.91551 1.000 11.80608 ? 757  HOH   B O   1 
HETATM 7876 O O   . HOH   J 6 .   ? 2.65647   2.21235   0.43364   1.000 23.37702 ? 758  HOH   B O   1 
HETATM 7877 O O   . HOH   J 6 .   ? 6.55061   43.67751  -7.26050  1.000 22.07007 ? 759  HOH   B O   1 
HETATM 7878 O O   . HOH   J 6 .   ? 14.24668  18.64789  -5.20217  1.000 11.11671 ? 760  HOH   B O   1 
HETATM 7879 O O   . HOH   J 6 .   ? 5.93497   -5.29862  -12.88941 1.000 14.30937 ? 761  HOH   B O   1 
HETATM 7880 O O   . HOH   J 6 .   ? 6.98260   0.55705   5.44429   1.000 45.82342 ? 762  HOH   B O   1 
HETATM 7881 O O   . HOH   J 6 .   ? -1.31950  13.46623  -32.54237 1.000 20.13926 ? 763  HOH   B O   1 
HETATM 7882 O O   . HOH   J 6 .   ? 6.47075   12.10363  -20.53793 1.000 23.69334 ? 764  HOH   B O   1 
HETATM 7883 O O   . HOH   J 6 .   ? 16.18197  20.48188  -46.18739 1.000 37.64630 ? 765  HOH   B O   1 
HETATM 7884 O O   . HOH   J 6 .   ? 10.68420  -18.29841 -16.76460 1.000 23.39761 ? 766  HOH   B O   1 
HETATM 7885 O O   . HOH   J 6 .   ? 6.06898   27.79048  -23.81374 1.000 12.09242 ? 767  HOH   B O   1 
HETATM 7886 O O   . HOH   J 6 .   ? 12.36518  -14.76104 -24.16194 1.000 21.27802 ? 768  HOH   B O   1 
HETATM 7887 O O   . HOH   J 6 .   ? -8.17845  38.20232  -17.32710 1.000 28.12110 ? 769  HOH   B O   1 
HETATM 7888 O O   . HOH   J 6 .   ? 3.62213   23.25596  -23.68389 1.000 10.98363 ? 770  HOH   B O   1 
HETATM 7889 O O   . HOH   J 6 .   ? 20.03760  -3.70985  -11.91089 1.000 26.14560 ? 771  HOH   B O   1 
HETATM 7890 O O   . HOH   J 6 .   ? 8.48762   2.84462   1.02958   1.000 18.67701 ? 772  HOH   B O   1 
HETATM 7891 O O   . HOH   J 6 .   ? 23.14425  0.80655   -17.51424 1.000 24.85520 ? 773  HOH   B O   1 
HETATM 7892 O O   . HOH   J 6 .   ? 3.59806   -8.91830  -15.06201 1.000 21.47718 ? 774  HOH   B O   1 
HETATM 7893 O O   . HOH   J 6 .   ? 8.87532   -8.96782  -24.98755 1.000 27.68206 ? 775  HOH   B O   1 
HETATM 7894 O O   . HOH   J 6 .   ? -1.01010  33.08517  -43.76785 1.000 17.48857 ? 776  HOH   B O   1 
HETATM 7895 O O   . HOH   J 6 .   ? 3.70674   -15.14075 -9.54602  1.000 31.74109 ? 777  HOH   B O   1 
HETATM 7896 O O   . HOH   J 6 .   ? -0.39126  23.90413  -24.77848 1.000 11.01252 ? 778  HOH   B O   1 
HETATM 7897 O O   . HOH   J 6 .   ? 2.14745   16.37316  -29.31662 1.000 29.63143 ? 779  HOH   B O   1 
HETATM 7898 O O   . HOH   J 6 .   ? 15.09146  8.91638   -0.70309  1.000 17.77600 ? 780  HOH   B O   1 
HETATM 7899 O O   . HOH   J 6 .   ? -3.53804  30.40537  -8.57059  1.000 32.10341 ? 781  HOH   B O   1 
HETATM 7900 O O   . HOH   J 6 .   ? 19.62683  -0.07891  -21.36152 1.000 21.08175 ? 782  HOH   B O   1 
HETATM 7901 O O   . HOH   J 6 .   ? 6.55989   -23.53091 -30.71178 1.000 33.78655 ? 783  HOH   B O   1 
HETATM 7902 O O   . HOH   J 6 .   ? -0.94457  1.84473   0.01835   1.000 30.82118 ? 784  HOH   B O   1 
HETATM 7903 O O   . HOH   J 6 .   ? 19.55073  -15.53006 -20.97818 1.000 31.07857 ? 785  HOH   B O   1 
HETATM 7904 O O   . HOH   J 6 .   ? -0.32998  18.36160  -9.20640  1.000 37.19721 ? 786  HOH   B O   1 
HETATM 7905 O O   . HOH   J 6 .   ? 7.45257   -16.02983 -1.65727  1.000 19.31421 ? 787  HOH   B O   1 
HETATM 7906 O O   . HOH   J 6 .   ? -5.39849  1.14025   -52.91757 1.000 30.68203 ? 788  HOH   B O   1 
HETATM 7907 O O   . HOH   J 6 .   ? 22.432    -8.971    -17.994   1.000 17.80707 ? 789  HOH   B O   1 
HETATM 7908 O O   . HOH   J 6 .   ? 23.193    -1.685    -20.740   1.000 28.25602 ? 790  HOH   B O   1 
HETATM 7909 O O   . HOH   J 6 .   ? 16.13122  34.04277  -4.44306  1.000 16.12523 ? 791  HOH   B O   1 
HETATM 7910 O O   . HOH   J 6 .   ? 28.555    18.488    -23.696   1.000 16.69431 ? 792  HOH   B O   1 
HETATM 7911 O O   . HOH   J 6 .   ? 22.412    -4.991    -20.091   1.000 25.76419 ? 793  HOH   B O   1 
HETATM 7912 O O   . HOH   J 6 .   ? -2.05196  -9.63629  1.86867   1.000 30.88599 ? 794  HOH   B O   1 
HETATM 7913 O O   . HOH   J 6 .   ? 18.16794  26.85830  -6.63410  1.000 25.00230 ? 795  HOH   B O   1 
HETATM 7914 O O   . HOH   J 6 .   ? 6.95729   28.97274  -11.29844 1.000 10.70438 ? 796  HOH   B O   1 
HETATM 7915 O O   . HOH   J 6 .   ? 13.77176  33.80428  -43.66186 1.000 28.64132 ? 797  HOH   B O   1 
HETATM 7916 O O   . HOH   J 6 .   ? 22.66625  37.11524  -37.26760 1.000 28.68119 ? 798  HOH   B O   1 
HETATM 7917 O O   . HOH   J 6 .   ? 27.37563  19.40274  -35.10021 1.000 32.11079 ? 799  HOH   B O   1 
HETATM 7918 O O   . HOH   J 6 .   ? 10.59907  1.21056   1.84466   1.000 21.25057 ? 800  HOH   B O   1 
HETATM 7919 O O   . HOH   J 6 .   ? 1.66123   23.10471  -13.40666 1.000 29.07494 ? 801  HOH   B O   1 
HETATM 7920 O O   . HOH   J 6 .   ? 20.43703  37.51529  -21.36059 1.000 22.61067 ? 802  HOH   B O   1 
HETATM 7921 O O   . HOH   J 6 .   ? -0.86674  24.12227  -9.33711  1.000 38.63553 ? 803  HOH   B O   1 
HETATM 7922 O O   . HOH   J 6 .   ? -2.54844  18.73190  -45.99512 1.000 29.42882 ? 804  HOH   B O   1 
HETATM 7923 O O   . HOH   J 6 .   ? 19.84903  33.09135  -41.69906 1.000 20.35624 ? 805  HOH   B O   1 
HETATM 7924 O O   . HOH   J 6 .   ? 1.156     51.300    -16.172   1.000 32.15858 ? 806  HOH   B O   1 
HETATM 7925 O O   . HOH   J 6 .   ? 7.08928   16.15929  -17.39554 1.000 30.49305 ? 807  HOH   B O   1 
HETATM 7926 O O   . HOH   J 6 .   ? 16.99230  -17.94292 -24.18888 1.000 31.81884 ? 808  HOH   B O   1 
HETATM 7927 O O   . HOH   J 6 .   ? 11.04784  42.03862  -46.41659 1.000 36.11121 ? 809  HOH   B O   1 
HETATM 7928 O O   . HOH   J 6 .   ? -3.90556  29.52681  -31.40806 1.000 25.45149 ? 810  HOH   B O   1 
HETATM 7929 O O   . HOH   J 6 .   ? 15.77075  3.09108   3.20192   1.000 27.40992 ? 811  HOH   B O   1 
HETATM 7930 O O   . HOH   J 6 .   ? -5.18040  14.84945  -52.13136 1.000 24.35744 ? 812  HOH   B O   1 
HETATM 7931 O O   . HOH   J 6 .   ? -3.44841  7.86974   -54.04747 1.000 38.26004 ? 813  HOH   B O   1 
HETATM 7932 O O   . HOH   J 6 .   ? -0.69335  5.53125   -4.63448  1.000 23.66664 ? 814  HOH   B O   1 
HETATM 7933 O O   . HOH   J 6 .   ? 27.31548  14.84541  -33.54751 1.000 33.30732 ? 815  HOH   B O   1 
HETATM 7934 O O   . HOH   J 6 .   ? 23.14885  30.80068  -36.58741 1.000 30.93062 ? 816  HOH   B O   1 
HETATM 7935 O O   . HOH   J 6 .   ? -1.16996  -8.46725  -16.08356 1.000 40.77279 ? 817  HOH   B O   1 
HETATM 7936 O O   . HOH   J 6 .   ? 5.61384   -3.60094  -23.24386 1.000 27.70104 ? 818  HOH   B O   1 
HETATM 7937 O O   . HOH   J 6 .   ? 18.18143  0.87450   -5.27181  1.000 29.16728 ? 819  HOH   B O   1 
HETATM 7938 O O   . HOH   J 6 .   ? 10.34919  33.20104  -49.42584 1.000 29.51521 ? 820  HOH   B O   1 
HETATM 7939 O O   . HOH   J 6 .   ? -4.38336  27.94228  -29.29495 1.000 21.31155 ? 821  HOH   B O   1 
HETATM 7940 O O   . HOH   J 6 .   ? 16.20401  15.52752  -18.37076 1.000 12.46277 ? 822  HOH   B O   1 
HETATM 7941 O O   . HOH   J 6 .   ? 20.20715  11.57884  -14.88278 1.000 11.81487 ? 823  HOH   B O   1 
HETATM 7942 O O   . HOH   J 6 .   ? 3.09086   35.03483  -14.05886 1.000 22.54329 ? 824  HOH   B O   1 
HETATM 7943 O O   . HOH   J 6 .   ? 18.07207  9.92798   -23.41636 1.000 13.11186 ? 825  HOH   B O   1 
HETATM 7944 O O   . HOH   J 6 .   ? -0.38960  46.18873  -33.06684 1.000 19.01829 ? 826  HOH   B O   1 
HETATM 7945 O O   . HOH   J 6 .   ? 17.80237  -12.23709 6.38919   1.000 27.90883 ? 827  HOH   B O   1 
HETATM 7946 O O   . HOH   J 6 .   ? 23.51612  0.52634   -15.19990 1.000 25.77042 ? 828  HOH   B O   1 
HETATM 7947 O O   . HOH   J 6 .   ? 6.99046   19.87134  -5.15401  1.000 22.91141 ? 829  HOH   B O   1 
HETATM 7948 O O   . HOH   J 6 .   ? 17.73913  12.55406  -22.54902 1.000 12.08222 ? 830  HOH   B O   1 
HETATM 7949 O O   . HOH   J 6 .   ? -5.05567  31.78415  -30.00290 1.000 20.81919 ? 831  HOH   B O   1 
HETATM 7950 O O   . HOH   J 6 .   ? 22.12221  23.23472  -23.76155 1.000 15.31981 ? 832  HOH   B O   1 
HETATM 7951 O O   . HOH   J 6 .   ? 0.70737   17.14329  -42.16657 1.000 21.73326 ? 833  HOH   B O   1 
HETATM 7952 O O   . HOH   J 6 .   ? 5.26590   24.69686  -14.94922 1.000 20.41898 ? 834  HOH   B O   1 
HETATM 7953 O O   . HOH   J 6 .   ? 4.90106   25.52908  -22.57429 1.000 11.35768 ? 835  HOH   B O   1 
HETATM 7954 O O   . HOH   J 6 .   ? 22.82208  23.50152  -38.54046 1.000 30.33062 ? 836  HOH   B O   1 
HETATM 7955 O O   . HOH   J 6 .   ? 18.54938  -10.95819 -27.20700 1.000 33.02092 ? 837  HOH   B O   1 
HETATM 7956 O O   . HOH   J 6 .   ? 18.88755  11.18280  -7.65873  1.000 17.96319 ? 838  HOH   B O   1 
HETATM 7957 O O   . HOH   J 6 .   ? 4.20100   20.56922  -12.90070 1.000 26.44397 ? 839  HOH   B O   1 
HETATM 7958 O O   . HOH   J 6 .   ? 23.93103  27.52246  -24.79267 1.000 27.49225 ? 840  HOH   B O   1 
HETATM 7959 O O   . HOH   J 6 .   ? -1.26859  39.65152  -45.13416 1.000 39.88459 ? 841  HOH   B O   1 
HETATM 7960 O O   . HOH   J 6 .   ? 8.40747   27.01757  -4.35219  1.000 17.28246 ? 842  HOH   B O   1 
HETATM 7961 O O   . HOH   J 6 .   ? -5.99299  20.76326  -14.92932 1.000 30.05958 ? 843  HOH   B O   1 
HETATM 7962 O O   . HOH   J 6 .   ? 18.59986  22.04633  -39.69156 1.000 19.06480 ? 844  HOH   B O   1 
HETATM 7963 O O   . HOH   J 6 .   ? 8.26496   -21.14193 -12.04980 1.000 38.44944 ? 845  HOH   B O   1 
HETATM 7964 O O   . HOH   J 6 .   ? 3.95940   -10.35160 -17.31749 1.000 17.38965 ? 846  HOH   B O   1 
HETATM 7965 O O   . HOH   J 6 .   ? 22.02707  -6.45219  -17.84851 1.000 27.71551 ? 847  HOH   B O   1 
HETATM 7966 O O   . HOH   J 6 .   ? 4.29420   16.02942  -11.68016 1.000 19.34162 ? 848  HOH   B O   1 
HETATM 7967 O O   . HOH   J 6 .   ? -3.19552  16.09705  -47.85723 1.000 29.40147 ? 849  HOH   B O   1 
HETATM 7968 O O   . HOH   J 6 .   ? -1.06894  -4.69269  -17.47696 1.000 33.77873 ? 850  HOH   B O   1 
HETATM 7969 O O   . HOH   J 6 .   ? 23.471    10.905    -8.708    1.000 32.39301 ? 851  HOH   B O   1 
HETATM 7970 O O   . HOH   J 6 .   ? 8.19509   27.76591  -1.88327  1.000 23.48025 ? 852  HOH   B O   1 
HETATM 7971 O O   . HOH   J 6 .   ? 17.64506  40.36670  -22.21892 1.000 27.23618 ? 853  HOH   B O   1 
HETATM 7972 O O   . HOH   J 6 .   ? 25.885    -5.738    -13.739   1.000 26.97661 ? 854  HOH   B O   1 
HETATM 7973 O O   . HOH   J 6 .   ? 4.49724   26.66498  -31.42637 1.000 18.11419 ? 855  HOH   B O   1 
HETATM 7974 O O   . HOH   J 6 .   ? 17.67959  40.03380  -31.84253 1.000 27.99671 ? 856  HOH   B O   1 
HETATM 7975 O O   . HOH   J 6 .   ? 23.550    -12.443   -18.125   1.000 16.05116 ? 857  HOH   B O   1 
HETATM 7976 O O   . HOH   J 6 .   ? 0.44058   11.30749  -37.65009 1.000 28.09547 ? 858  HOH   B O   1 
HETATM 7977 O O   . HOH   J 6 .   ? 14.00649  -17.34483 0.28054   1.000 23.73166 ? 859  HOH   B O   1 
HETATM 7978 O O   . HOH   J 6 .   ? -2.10375  -1.03666  -15.75952 1.000 35.88876 ? 860  HOH   B O   1 
HETATM 7979 O O   . HOH   J 6 .   ? 24.76656  30.46527  -31.49462 1.000 20.97337 ? 861  HOH   B O   1 
HETATM 7980 O O   . HOH   J 6 .   ? -4.92003  30.49659  -27.62946 1.000 17.51749 ? 862  HOH   B O   1 
HETATM 7981 O O   . HOH   J 6 .   ? 0.63647   32.40484  -3.96696  1.000 31.24147 ? 863  HOH   B O   1 
HETATM 7982 O O   . HOH   J 6 .   ? 30.127    12.449    -19.336   1.000 25.35955 ? 864  HOH   B O   1 
HETATM 7983 O O   . HOH   J 6 .   ? 7.60759   17.89020  -25.83130 1.000 25.32356 ? 865  HOH   B O   1 
HETATM 7984 O O   . HOH   J 6 .   ? 0.69101   36.50724  -42.74472 1.000 17.66051 ? 866  HOH   B O   1 
HETATM 7985 O O   . HOH   J 6 .   ? 1.935     10.477    -49.109   1.000 31.00181 ? 867  HOH   B O   1 
HETATM 7986 O O   . HOH   J 6 .   ? 12.43085  -12.17199 -25.46463 1.000 28.99481 ? 868  HOH   B O   1 
HETATM 7987 O O   . HOH   J 6 .   ? 18.76103  -1.97892  -5.38685  1.000 31.59472 ? 869  HOH   B O   1 
HETATM 7988 O O   . HOH   J 6 .   ? 17.47559  15.07387  2.82331   1.000 35.55597 ? 870  HOH   B O   1 
HETATM 7989 O O   . HOH   J 6 .   ? 16.36961  17.89738  -19.90205 1.000 9.54002  ? 871  HOH   B O   1 
HETATM 7990 O O   . HOH   J 6 .   ? 3.59143   23.09865  -19.04823 1.000 7.46332  ? 872  HOH   B O   1 
HETATM 7991 O O   . HOH   J 6 .   ? -6.59034  28.35022  -16.32307 1.000 31.71429 ? 873  HOH   B O   1 
HETATM 7992 O O   . HOH   J 6 .   ? 17.26250  -2.21722  -28.82736 1.000 23.74018 ? 874  HOH   B O   1 
HETATM 7993 O O   . HOH   J 6 .   ? 0.59802   11.13185  -7.80611  1.000 26.50879 ? 875  HOH   B O   1 
HETATM 7994 O O   . HOH   J 6 .   ? 0.95958   22.09323  -26.57897 1.000 12.90736 ? 876  HOH   B O   1 
HETATM 7995 O O   . HOH   J 6 .   ? -5.43059  40.53159  -21.10775 1.000 32.80008 ? 877  HOH   B O   1 
HETATM 7996 O O   . HOH   J 6 .   ? 8.87477   -18.70763 -10.31905 1.000 24.21496 ? 878  HOH   B O   1 
HETATM 7997 O O   . HOH   J 6 .   ? -2.32179  28.65058  -4.30884  1.000 31.43250 ? 879  HOH   B O   1 
HETATM 7998 O O   . HOH   J 6 .   ? 19.20131  45.60988  -38.48728 1.000 38.05663 ? 880  HOH   B O   1 
HETATM 7999 O O   . HOH   J 6 .   ? -1.88195  42.52049  -16.63529 1.000 33.31029 ? 881  HOH   B O   1 
HETATM 8000 O O   . HOH   J 6 .   ? -1.03768  46.29411  -26.59458 1.000 24.10127 ? 882  HOH   B O   1 
HETATM 8001 O O   . HOH   J 6 .   ? 21.65686  0.96696   -24.95668 1.000 22.23719 ? 883  HOH   B O   1 
HETATM 8002 O O   . HOH   J 6 .   ? -0.75641  13.91546  -45.27132 1.000 26.81454 ? 884  HOH   B O   1 
HETATM 8003 O O   . HOH   J 6 .   ? 2.33015   -19.34814 -26.99463 1.000 29.86482 ? 885  HOH   B O   1 
HETATM 8004 O O   . HOH   J 6 .   ? -0.43253  34.16079  -7.19226  1.000 24.47491 ? 886  HOH   B O   1 
HETATM 8005 O O   . HOH   J 6 .   ? 16.44002  17.13500  -40.15430 1.000 22.22095 ? 887  HOH   B O   1 
HETATM 8006 O O   . HOH   J 6 .   ? 21.19003  9.81889   -9.16859  1.000 21.96503 ? 888  HOH   B O   1 
HETATM 8007 O O   . HOH   J 6 .   ? -1.969    6.863     -62.697   1.000 39.24444 ? 889  HOH   B O   1 
HETATM 8008 O O   . HOH   J 6 .   ? 12.61223  28.34833  -48.88070 1.000 36.01877 ? 890  HOH   B O   1 
HETATM 8009 O O   . HOH   J 6 .   ? 9.13286   16.05952  -1.53524  1.000 17.72775 ? 891  HOH   B O   1 
HETATM 8010 O O   . HOH   J 6 .   ? 24.62544  -3.37047  -14.88290 1.000 32.43085 ? 892  HOH   B O   1 
HETATM 8011 O O   . HOH   J 6 .   ? 18.38754  -13.01110 2.56068   1.000 34.55410 ? 893  HOH   B O   1 
HETATM 8012 O O   . HOH   J 6 .   ? 11.21233  24.58846  -46.59627 1.000 25.17647 ? 894  HOH   B O   1 
HETATM 8013 O O   . HOH   J 6 .   ? 10.31051  4.42959   -20.27504 1.000 27.41728 ? 895  HOH   B O   1 
HETATM 8014 O O   . HOH   J 6 .   ? 23.14822  12.29880  -6.93167  1.000 29.02327 ? 896  HOH   B O   1 
HETATM 8015 O O   . HOH   J 6 .   ? 9.25925   -21.81540 -1.54201  1.000 27.61246 ? 897  HOH   B O   1 
HETATM 8016 O O   . HOH   J 6 .   ? 8.02694   17.86349  -28.87153 1.000 22.31445 ? 898  HOH   B O   1 
HETATM 8017 O O   . HOH   J 6 .   ? 27.78532  24.98319  -19.00378 1.000 34.16470 ? 899  HOH   B O   1 
HETATM 8018 O O   . HOH   J 6 .   ? 2.64222   -9.27322  -24.21041 1.000 26.34519 ? 900  HOH   B O   1 
HETATM 8019 O O   . HOH   J 6 .   ? 17.31686  31.99973  -2.82827  1.000 20.36238 ? 901  HOH   B O   1 
HETATM 8020 O O   . HOH   J 6 .   ? -0.03561  16.37144  -44.80136 1.000 27.13333 ? 902  HOH   B O   1 
HETATM 8021 O O   . HOH   J 6 .   ? 19.55260  3.92086   -33.07284 1.000 24.07765 ? 903  HOH   B O   1 
HETATM 8022 O O   . HOH   J 6 .   ? 4.66048   31.68259  -23.88435 1.000 12.73441 ? 904  HOH   B O   1 
HETATM 8023 O O   . HOH   J 6 .   ? 24.77737  22.50767  -15.27149 1.000 16.64173 ? 905  HOH   B O   1 
HETATM 8024 O O   . HOH   J 6 .   ? 2.63329   17.67711  -16.53358 1.000 32.61852 ? 906  HOH   B O   1 
HETATM 8025 O O   . HOH   J 6 .   ? -0.66914  28.02761  -32.03042 1.000 16.11184 ? 907  HOH   B O   1 
HETATM 8026 O O   . HOH   J 6 .   ? -0.66824  -15.91404 -0.75433  1.000 32.20326 ? 908  HOH   B O   1 
HETATM 8027 O O   . HOH   J 6 .   ? -0.90440  2.45139   -16.77002 1.000 30.88936 ? 909  HOH   B O   1 
HETATM 8028 O O   . HOH   J 6 .   ? 2.67713   51.10085  -24.41163 1.000 24.74691 ? 910  HOH   B O   1 
HETATM 8029 O O   . HOH   J 6 .   ? 11.05345  -11.66761 3.92331   1.000 22.16764 ? 911  HOH   B O   1 
HETATM 8030 O O   . HOH   J 6 .   ? 11.85754  45.52952  -29.77533 1.000 33.16578 ? 912  HOH   B O   1 
HETATM 8031 O O   . HOH   J 6 .   ? 3.50965   42.47544  -44.68363 1.000 21.78321 ? 913  HOH   B O   1 
HETATM 8032 O O   . HOH   J 6 .   ? 18.02839  25.76117  -3.40912  1.000 26.96554 ? 914  HOH   B O   1 
HETATM 8033 O O   . HOH   J 6 .   ? 25.47529  7.43118   -34.75082 1.000 26.71069 ? 915  HOH   B O   1 
HETATM 8034 O O   . HOH   J 6 .   ? 17.57908  24.77233  -0.94733  1.000 19.00691 ? 916  HOH   B O   1 
HETATM 8035 O O   . HOH   J 6 .   ? 2.74185   -15.56321 -21.80752 1.000 27.09663 ? 917  HOH   B O   1 
HETATM 8036 O O   . HOH   J 6 .   ? -4.04686  18.34448  -24.30428 1.000 31.41109 ? 918  HOH   B O   1 
HETATM 8037 O O   . HOH   J 6 .   ? 11.68460  40.89404  -27.40890 1.000 27.98409 ? 919  HOH   B O   1 
HETATM 8038 O O   . HOH   J 6 .   ? 4.75994   27.35856  0.03557   1.000 25.33057 ? 920  HOH   B O   1 
HETATM 8039 O O   . HOH   J 6 .   ? 15.11561  20.54904  -17.43127 1.000 22.78161 ? 921  HOH   B O   1 
HETATM 8040 O O   . HOH   J 6 .   ? -0.22300  -3.52428  4.23993   1.000 32.81258 ? 922  HOH   B O   1 
HETATM 8041 O O   . HOH   J 6 .   ? 25.09153  18.88694  -28.18989 1.000 32.34516 ? 923  HOH   B O   1 
HETATM 8042 O O   . HOH   J 6 .   ? 1.07317   2.40023   2.40680   1.000 32.75885 ? 924  HOH   B O   1 
HETATM 8043 O O   . HOH   J 6 .   ? 18.55605  18.83661  -1.94349  1.000 29.36312 ? 925  HOH   B O   1 
HETATM 8044 O O   . HOH   J 6 .   ? 6.44836   26.98655  -29.51234 1.000 12.69359 ? 926  HOH   B O   1 
HETATM 8045 O O   . HOH   J 6 .   ? 14.00905  19.57966  5.66606   1.000 33.37475 ? 927  HOH   B O   1 
HETATM 8046 O O   . HOH   J 6 .   ? -10.36207 25.67050  -22.11214 1.000 30.02981 ? 928  HOH   B O   1 
HETATM 8047 O O   . HOH   J 6 .   ? 9.66290   49.09942  -41.69739 1.000 40.96124 ? 929  HOH   B O   1 
HETATM 8048 O O   . HOH   J 6 .   ? 4.64306   -24.23693 -29.19499 1.000 30.72972 ? 930  HOH   B O   1 
HETATM 8049 O O   . HOH   J 6 .   ? 27.08675  12.67769  -12.23884 1.000 15.01853 ? 931  HOH   B O   1 
HETATM 8050 O O   . HOH   J 6 .   ? 21.83386  24.33984  -16.63096 1.000 27.89719 ? 932  HOH   B O   1 
HETATM 8051 O O   . HOH   J 6 .   ? 16.17883  40.74059  -28.95582 1.000 33.47358 ? 933  HOH   B O   1 
HETATM 8052 O O   . HOH   J 6 .   ? 22.91380  21.24697  -12.25410 1.000 20.15949 ? 934  HOH   B O   1 
HETATM 8053 O O   . HOH   J 6 .   ? 9.38989   6.64900   -25.37542 1.000 34.61225 ? 935  HOH   B O   1 
HETATM 8054 O O   . HOH   J 6 .   ? 26.35667  9.02621   -27.36778 1.000 23.48017 ? 936  HOH   B O   1 
HETATM 8055 O O   . HOH   J 6 .   ? -2.90396  8.14108   -59.80286 1.000 37.24639 ? 937  HOH   B O   1 
HETATM 8056 O O   . HOH   J 6 .   ? 8.75805   11.24271  0.94616   1.000 34.11521 ? 938  HOH   B O   1 
HETATM 8057 O O   . HOH   J 6 .   ? 24.20991  20.84371  -28.81720 1.000 14.78154 ? 939  HOH   B O   1 
HETATM 8058 O O   . HOH   J 6 .   ? -2.95914  4.69479   -9.34216  1.000 4.95834  ? 940  HOH   B O   1 
HETATM 8059 O O   . HOH   J 6 .   ? 23.27961  -4.59695  -5.51892  1.000 29.86863 ? 941  HOH   B O   1 
HETATM 8060 O O   . HOH   J 6 .   ? 4.52424   22.42581  -16.24194 1.000 17.57899 ? 942  HOH   B O   1 
HETATM 8061 O O   . HOH   J 6 .   ? -3.36958  17.26532  -17.47284 1.000 35.44025 ? 943  HOH   B O   1 
HETATM 8062 O O   . HOH   J 6 .   ? 17.02450  1.49950   -7.29638  1.000 30.47853 ? 944  HOH   B O   1 
HETATM 8063 O O   . HOH   J 6 .   ? 6.13410   40.43956  -45.57408 1.000 19.10393 ? 945  HOH   B O   1 
HETATM 8064 O O   . HOH   J 6 .   ? 26.00199  15.59608  -36.72489 1.000 19.46982 ? 946  HOH   B O   1 
HETATM 8065 O O   . HOH   J 6 .   ? 19.73855  -8.17238  -24.63637 1.000 26.35492 ? 947  HOH   B O   1 
HETATM 8066 O O   . HOH   J 6 .   ? 20.68797  18.36047  -40.86522 1.000 23.11123 ? 948  HOH   B O   1 
HETATM 8067 O O   . HOH   J 6 .   ? 21.42166  30.71524  -13.25316 1.000 36.55582 ? 949  HOH   B O   1 
HETATM 8068 O O   . HOH   J 6 .   ? 8.62405   13.49941  2.41704   1.000 33.00570 ? 950  HOH   B O   1 
HETATM 8069 O O   . HOH   J 6 .   ? 23.82075  -5.38091  -15.87934 1.000 30.43532 ? 951  HOH   B O   1 
HETATM 8070 O O   . HOH   J 6 .   ? 21.39871  -6.38407  -26.80543 1.000 35.05915 ? 952  HOH   B O   1 
HETATM 8071 O O   . HOH   J 6 .   ? 5.51963   23.30813  -45.14010 1.000 23.77289 ? 953  HOH   B O   1 
HETATM 8072 O O   . HOH   J 6 .   ? 4.96620   -19.66963 -7.18954  1.000 25.26235 ? 954  HOH   B O   1 
HETATM 8073 O O   . HOH   J 6 .   ? 7.46183   24.44678  -46.15257 1.000 20.63884 ? 955  HOH   B O   1 
HETATM 8074 O O   . HOH   J 6 .   ? -10.05922 33.60722  -26.65130 1.000 41.59251 ? 956  HOH   B O   1 
HETATM 8075 O O   . HOH   J 6 .   ? 13.33014  9.11381   2.45365   1.000 27.75000 ? 957  HOH   B O   1 
HETATM 8076 O O   . HOH   J 6 .   ? 10.18597  13.43712  -37.92198 1.000 31.16740 ? 958  HOH   B O   1 
HETATM 8077 O O   . HOH   J 6 .   ? 2.824     53.681    -19.124   1.000 30.61906 ? 959  HOH   B O   1 
HETATM 8078 O O   . HOH   J 6 .   ? 29.721    11.986    -14.893   1.000 19.99010 ? 960  HOH   B O   1 
HETATM 8079 O O   . HOH   J 6 .   ? -6.70649  16.45746  -41.28093 1.000 30.56215 ? 961  HOH   B O   1 
HETATM 8080 O O   . HOH   J 6 .   ? -8.15285  10.66347  -63.22131 1.000 37.39083 ? 962  HOH   B O   1 
HETATM 8081 O O   . HOH   J 6 .   ? -9.67903  5.84791   -31.50093 1.000 36.18501 ? 963  HOH   B O   1 
HETATM 8082 O O   . HOH   J 6 .   ? -1.36567  17.43445  -27.75677 1.000 25.27315 ? 964  HOH   B O   1 
HETATM 8083 O O   . HOH   J 6 .   ? 16.52850  24.85130  -43.51419 1.000 35.94034 ? 965  HOH   B O   1 
HETATM 8084 O O   . HOH   J 6 .   ? -12.32344 33.31302  -18.79566 1.000 30.16479 ? 966  HOH   B O   1 
HETATM 8085 O O   . HOH   J 6 .   ? -4.38835  -2.89342  -10.53986 1.000 37.02082 ? 967  HOH   B O   1 
HETATM 8086 O O   . HOH   J 6 .   ? 15.70941  13.55689  -20.78797 1.000 14.87458 ? 968  HOH   B O   1 
HETATM 8087 O O   . HOH   J 6 .   ? 14.61318  16.26469  2.52467   1.000 29.99934 ? 969  HOH   B O   1 
HETATM 8088 O O   . HOH   J 6 .   ? 1.87545   29.77281  -0.12632  1.000 28.39376 ? 970  HOH   B O   1 
HETATM 8089 O O   . HOH   J 6 .   ? 2.58350   15.34981  -0.35338  1.000 34.68193 ? 971  HOH   B O   1 
HETATM 8090 O O   . HOH   J 6 .   ? 0.39463   -17.27842 -2.71082  1.000 34.41671 ? 972  HOH   B O   1 
HETATM 8091 O O   . HOH   J 6 .   ? 5.92803   14.58836  -19.19034 1.000 36.01355 ? 973  HOH   B O   1 
HETATM 8092 O O   . HOH   J 6 .   ? -2.67665  39.43031  -24.17894 1.000 26.56072 ? 974  HOH   B O   1 
HETATM 8093 O O   . HOH   J 6 .   ? 22.57120  5.78763   -13.16181 1.000 34.89929 ? 975  HOH   B O   1 
HETATM 8094 O O   . HOH   J 6 .   ? 22.13061  34.58080  -22.24630 1.000 20.51033 ? 976  HOH   B O   1 
HETATM 8095 O O   . HOH   J 6 .   ? 17.31051  42.64369  -23.57202 1.000 34.86133 ? 977  HOH   B O   1 
HETATM 8096 O O   . HOH   J 6 .   ? 9.69033   15.58040  1.68138   1.000 35.59404 ? 978  HOH   B O   1 
HETATM 8097 O O   . HOH   J 6 .   ? 22.43033  35.86932  -7.55043  1.000 24.72701 ? 979  HOH   B O   1 
HETATM 8098 O O   . HOH   J 6 .   ? 3.62313   35.73447  -50.19994 1.000 29.94254 ? 980  HOH   B O   1 
HETATM 8099 O O   . HOH   J 6 .   ? 24.39378  24.89953  -24.09260 1.000 26.00940 ? 981  HOH   B O   1 
HETATM 8100 O O   . HOH   J 6 .   ? -3.22523  34.96332  -8.00360  1.000 39.58526 ? 982  HOH   B O   1 
HETATM 8101 O O   . HOH   J 6 .   ? 15.43583  46.46777  -10.48632 1.000 22.97244 ? 983  HOH   B O   1 
HETATM 8102 O O   . HOH   J 6 .   ? 20.23127  44.14418  -17.96468 1.000 35.37492 ? 984  HOH   B O   1 
HETATM 8103 O O   . HOH   J 6 .   ? 27.52397  19.77235  -31.56376 1.000 32.85559 ? 985  HOH   B O   1 
HETATM 8104 O O   . HOH   J 6 .   ? 22.78750  6.55557   -10.99529 1.000 35.22560 ? 986  HOH   B O   1 
HETATM 8105 O O   . HOH   J 6 .   ? 17.18392  27.14368  -43.69723 1.000 38.82500 ? 987  HOH   B O   1 
HETATM 8106 O O   . HOH   J 6 .   ? 7.68257   20.90408  -2.78139  1.000 33.71061 ? 988  HOH   B O   1 
HETATM 8107 O O   . HOH   J 6 .   ? 22.17605  41.17594  -29.75090 1.000 36.90650 ? 989  HOH   B O   1 
HETATM 8108 O O   . HOH   J 6 .   ? 11.10665  -10.04630 -26.53207 1.000 24.44210 ? 990  HOH   B O   1 
HETATM 8109 O O   . HOH   J 6 .   ? -0.53457  22.44370  -15.41643 1.000 36.98573 ? 991  HOH   B O   1 
HETATM 8110 O O   . HOH   J 6 .   ? 6.61168   -21.64605 -16.58124 1.000 35.91049 ? 992  HOH   B O   1 
HETATM 8111 O O   . HOH   J 6 .   ? 4.53963   37.49182  -8.11887  1.000 21.06961 ? 993  HOH   B O   1 
HETATM 8112 O O   . HOH   J 6 .   ? 2.469     -16.592   5.250     1.000 33.64132 ? 994  HOH   B O   1 
HETATM 8113 O O   . HOH   J 6 .   ? 1.82385   21.45915  -15.33584 1.000 31.28977 ? 995  HOH   B O   1 
HETATM 8114 O O   . HOH   J 6 .   ? 0.16988   43.89409  -12.23439 1.000 31.15506 ? 996  HOH   B O   1 
HETATM 8115 O O   . HOH   J 6 .   ? -11.62507 35.46951  -19.49105 1.000 36.96608 ? 997  HOH   B O   1 
HETATM 8116 O O   . HOH   J 6 .   ? -10.507   29.656    -36.389   1.000 34.23508 ? 998  HOH   B O   1 
HETATM 8117 O O   . HOH   J 6 .   ? -3.64583  -0.22642  -0.70121  1.000 31.16633 ? 999  HOH   B O   1 
HETATM 8118 O O   . HOH   J 6 .   ? 23.22236  33.84732  -19.67250 1.000 29.29414 ? 1000 HOH   B O   1 
HETATM 8119 O O   . HOH   J 6 .   ? 25.08525  -0.54549  -16.89393 1.000 34.40541 ? 1001 HOH   B O   1 
HETATM 8120 O O   . HOH   J 6 .   ? 18.97240  7.05198   -38.13270 1.000 33.12656 ? 1002 HOH   B O   1 
HETATM 8121 O O   . HOH   J 6 .   ? -4.02338  -10.85556 0.14163   1.000 32.85195 ? 1003 HOH   B O   1 
HETATM 8122 O O   . HOH   J 6 .   ? 22.97202  33.68072  -24.54901 1.000 30.33183 ? 1004 HOH   B O   1 
HETATM 8123 O O   . HOH   J 6 .   ? 19.67656  25.29178  -5.74625  1.000 34.17569 ? 1005 HOH   B O   1 
HETATM 8124 O O   . HOH   J 6 .   ? 4.42145   52.45846  -23.20544 1.000 37.81791 ? 1006 HOH   B O   1 
HETATM 8125 O O   . HOH   J 6 .   ? 14.07416  41.98170  -27.60855 1.000 37.35123 ? 1007 HOH   B O   1 
HETATM 8126 O O   . HOH   J 6 .   ? 22.02966  33.52254  -40.63794 1.000 30.81121 ? 1008 HOH   B O   1 
HETATM 8127 O O   . HOH   J 6 .   ? 2.28059   -11.90721 -25.19107 1.000 28.66034 ? 1009 HOH   B O   1 
HETATM 8128 O O   . HOH   J 6 .   ? 8.55639   -24.21572 -2.53437  1.000 28.13597 ? 1010 HOH   B O   1 
HETATM 8129 O O   . HOH   J 6 .   ? 21.09965  22.43115  -39.63125 1.000 35.65939 ? 1011 HOH   B O   1 
HETATM 8130 O O   . HOH   J 6 .   ? 4.91511   19.86856  -26.46573 1.000 26.02422 ? 1012 HOH   B O   1 
HETATM 8131 O O   . HOH   J 6 .   ? 11.51396  21.65613  -45.97765 1.000 24.84851 ? 1013 HOH   B O   1 
HETATM 8132 O O   . HOH   J 6 .   ? 25.38742  31.32470  -34.88170 1.000 32.09486 ? 1014 HOH   B O   1 
HETATM 8133 O O   . HOH   J 6 .   ? 11.309    35.112    -0.885    1.000 24.97069 ? 1015 HOH   B O   1 
HETATM 8134 O O   . HOH   J 6 .   ? -3.44266  8.14578   -2.55244  1.000 32.52569 ? 1016 HOH   B O   1 
HETATM 8135 O O   . HOH   J 6 .   ? 14.71471  -20.63717 -16.39406 1.000 25.53474 ? 1017 HOH   B O   1 
HETATM 8136 O O   . HOH   J 6 .   ? 7.708     -20.814   0.535     1.000 37.96212 ? 1018 HOH   B O   1 
HETATM 8137 O O   . HOH   J 6 .   ? 22.22454  21.52075  -41.93025 1.000 39.21187 ? 1019 HOH   B O   1 
HETATM 8138 O O   . HOH   J 6 .   ? -7.59930  31.90108  -30.03681 1.000 36.90486 ? 1020 HOH   B O   1 
HETATM 8139 O O   . HOH   J 6 .   ? 17.84911  23.24651  -42.17784 1.000 31.08952 ? 1021 HOH   B O   1 
HETATM 8140 O O   . HOH   J 6 .   ? 22.05795  1.10552   -20.75318 1.000 28.54849 ? 1022 HOH   B O   1 
HETATM 8141 O O   . HOH   J 6 .   ? 7.93464   28.57721  -25.59614 1.000 11.10144 ? 1023 HOH   B O   1 
HETATM 8142 O O   . HOH   J 6 .   ? 0.17877   19.62780  -24.20327 1.000 32.18316 ? 1024 HOH   B O   1 
HETATM 8143 O O   . HOH   J 6 .   ? -1.63663  18.11526  -25.23289 1.000 35.87118 ? 1025 HOH   B O   1 
HETATM 8144 O O   . HOH   J 6 .   ? -2.89219  0.17840   -18.32471 1.000 41.04944 ? 1026 HOH   B O   1 
HETATM 8145 O O   . HOH   J 6 .   ? 13.68744  -16.38691 -26.32930 1.000 30.77801 ? 1027 HOH   B O   1 
HETATM 8146 O O   . HOH   J 6 .   ? -1.18566  8.26182   -20.05523 1.000 31.75568 ? 1028 HOH   B O   1 
HETATM 8147 O O   . HOH   J 6 .   ? 22.51956  -0.91088  -26.79618 1.000 34.02058 ? 1029 HOH   B O   1 
HETATM 8148 O O   . HOH   J 6 .   ? 23.75147  4.42832   -19.00585 1.000 29.53348 ? 1030 HOH   B O   1 
HETATM 8149 O O   . HOH   J 6 .   ? 17.36548  -13.68052 0.20983   1.000 26.87699 ? 1031 HOH   B O   1 
HETATM 8150 O O   . HOH   J 6 .   ? 23.29952  6.51821   -8.75049  1.000 39.30119 ? 1032 HOH   B O   1 
HETATM 8151 O O   . HOH   J 6 .   ? -5.45288  31.53719  -6.56850  1.000 37.35684 ? 1033 HOH   B O   1 
HETATM 8152 O O   . HOH   J 6 .   ? 3.10371   -19.46609 -29.57941 1.000 28.55168 ? 1034 HOH   B O   1 
HETATM 8153 O O   . HOH   J 6 .   ? 26.47002  25.48338  -37.49537 1.000 32.65579 ? 1035 HOH   B O   1 
HETATM 8154 O O   . HOH   J 6 .   ? 27.65685  11.80944  -32.78228 1.000 34.04655 ? 1036 HOH   B O   1 
HETATM 8155 O O   . HOH   J 6 .   ? 25.40604  32.77995  -20.64539 1.000 36.95693 ? 1037 HOH   B O   1 
HETATM 8156 O O   . HOH   J 6 .   ? -4.30816  17.32865  -29.84439 1.000 27.63833 ? 1038 HOH   B O   1 
HETATM 8157 O O   . HOH   J 6 .   ? 21.35329  32.54053  -15.24950 1.000 36.22872 ? 1039 HOH   B O   1 
HETATM 8158 O O   . HOH   J 6 .   ? 0.11841   12.52986  -42.87707 1.000 33.67613 ? 1040 HOH   B O   1 
HETATM 8159 O O   . HOH   J 6 .   ? -9.37496  22.84606  -15.50435 1.000 22.69110 ? 1041 HOH   B O   1 
HETATM 8160 O O   . HOH   J 6 .   ? 28.770    9.909     -13.750   1.000 31.02421 ? 1042 HOH   B O   1 
HETATM 8161 O O   . HOH   J 6 .   ? 24.42285  13.87852  -3.41815  1.000 36.46829 ? 1043 HOH   B O   1 
HETATM 8162 O O   . HOH   J 6 .   ? 6.419     -25.200   -0.806    1.000 31.06820 ? 1044 HOH   B O   1 
HETATM 8163 O O   . HOH   J 6 .   ? 18.02343  19.06597  -40.79811 1.000 19.46782 ? 1045 HOH   B O   1 
HETATM 8164 O O   . HOH   J 6 .   ? 8.03927   5.85798   -23.12846 1.000 41.97212 ? 1046 HOH   B O   1 
HETATM 8165 O O   . HOH   J 6 .   ? 22.071    -7.858    -28.711   1.000 37.73896 ? 1047 HOH   B O   1 
HETATM 8166 O O   . HOH   J 6 .   ? 23.78498  28.91840  -38.18947 1.000 25.04310 ? 1048 HOH   B O   1 
# 
