data_9C09
# 
_entry.id   9C09 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9C09         pdb_00009c09 10.2210/pdb9c09/pdb 
WWPDB D_1000284457 ?            ?                   
EMDB  EMD-45077    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Half map'        1 0 2025-02-26 1 
4 'Half map'        1 0 2025-02-26 2 
5 Image             1 0 2025-02-26 ? 
6 'Primary map'     1 0 2025-02-26 ? 
7 'Structure model' 1 1 2025-03-12 ? 
8 'Structure model' 1 2 2025-06-04 ? 
9 'EM metadata'     1 1 2025-06-04 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 7 'Structure model' 'Data collection'      
2 7 'Structure model' 'Database references'  
3 8 'Structure model' 'Data collection'      
4 9 'EM metadata'     'Data processing'      
5 9 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 7 'Structure model' citation        
2 7 'Structure model' citation_author 
3 7 'Structure model' em_admin        
4 8 'Structure model' em_admin        
5 8 'Structure model' em_software     
6 9 'EM metadata'     em_admin        
7 9 'EM metadata'     em_software     
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  7 'Structure model' '_citation.country'                 
2  7 'Structure model' '_citation.journal_abbrev'          
3  7 'Structure model' '_citation.journal_id_CSD'          
4  7 'Structure model' '_citation.journal_id_ISSN'         
5  7 'Structure model' '_citation.pdbx_database_id_DOI'    
6  7 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  7 'Structure model' '_citation.title'                   
8  7 'Structure model' '_citation.year'                    
9  7 'Structure model' '_em_admin.last_update'             
10 8 'Structure model' '_em_admin.last_update'             
11 8 'Structure model' '_em_software.name'                 
12 9 'EM metadata'     '_em_admin.last_update'             
13 9 'EM metadata'     '_em_software.name'                 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9C09 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  .                                                      9BSN      unspecified            
EMDB .                                                      EMD-44870 'other EM volume'      
EMDB 'Structure of K2P13.1 (THIK1) S136P in lipid nanodisc' EMD-45077 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              Daniel.Minor@ucsf.edu 
_pdbx_contact_author.name_first         Daniel 
_pdbx_contact_author.name_last          Minor 
_pdbx_contact_author.name_mi            L 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5998-4214 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Roy-Chowdhury, S.'  1 0000-0001-7128-7668 
'Adberemane-Ali, F.' 2 0000-0002-7097-1684 
'Minor, D.L.'        3 0000-0002-5998-4214 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nat.Struct.Mol.Biol. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1545-9985 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41594-024-01476-3 
_citation.pdbx_database_id_PubMed   40011746 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Roy-Chowdhury, S.'  1 ?                   
primary 'Jang, S.'           2 ?                   
primary 'Abderemane-Ali, F.' 3 0000-0002-7097-1684 
primary 'Naughton, F.'       4 0000-0003-0162-1346 
primary 'Grabe, M.'          5 0000-0003-3509-5997 
primary 'Minor Jr., D.L.'    6 0000-0002-5998-4214 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Potassium channel subfamily K member 13' 39383.613 2 ? 'N59Q, N65Q, S136P' 
'human K2P13.1 (THIK1) residues 1 to 350 followed by SNS linker and then 3C protease cleavage site' ? 
2 non-polymer syn DODECANE                                  170.335   2 ? ?                   ? ? 
3 non-polymer syn DECANE                                    142.282   4 ? ?                   ? ? 
4 non-polymer syn N-OCTANE                                  114.229   8 ? ?                   ? ? 
5 non-polymer syn 'LINOLEIC ACID'                           280.445   2 ? ?                   ? ? 
6 non-polymer syn HEXANE                                    86.175    2 ? ?                   ? ? 
7 non-polymer syn 'POTASSIUM ION'                           39.098    4 ? ?                   ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Tandem pore domain halothane-inhibited potassium channel 1,THIK-1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLAQFSRGHQLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCPSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLAQFSRGHQLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCPSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_entity_poly.pdbx_strand_id                 U,A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 DODECANE        D12 
3 DECANE          D10 
4 N-OCTANE        OCT 
5 'LINOLEIC ACID' EIC 
6 HEXANE          HEX 
7 'POTASSIUM ION' K   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   GLY n 
1 4   ARG n 
1 5   GLY n 
1 6   PHE n 
1 7   SER n 
1 8   TRP n 
1 9   GLY n 
1 10  PRO n 
1 11  GLY n 
1 12  HIS n 
1 13  LEU n 
1 14  ASN n 
1 15  GLU n 
1 16  ASP n 
1 17  ASN n 
1 18  ALA n 
1 19  ARG n 
1 20  PHE n 
1 21  LEU n 
1 22  LEU n 
1 23  LEU n 
1 24  ALA n 
1 25  ALA n 
1 26  LEU n 
1 27  ILE n 
1 28  VAL n 
1 29  LEU n 
1 30  TYR n 
1 31  LEU n 
1 32  LEU n 
1 33  GLY n 
1 34  GLY n 
1 35  ALA n 
1 36  ALA n 
1 37  VAL n 
1 38  PHE n 
1 39  SER n 
1 40  ALA n 
1 41  LEU n 
1 42  GLU n 
1 43  LEU n 
1 44  ALA n 
1 45  HIS n 
1 46  GLU n 
1 47  ARG n 
1 48  GLN n 
1 49  ALA n 
1 50  LYS n 
1 51  GLN n 
1 52  ARG n 
1 53  TRP n 
1 54  GLU n 
1 55  GLU n 
1 56  ARG n 
1 57  LEU n 
1 58  ALA n 
1 59  GLN n 
1 60  PHE n 
1 61  SER n 
1 62  ARG n 
1 63  GLY n 
1 64  HIS n 
1 65  GLN n 
1 66  LEU n 
1 67  SER n 
1 68  ARG n 
1 69  ASP n 
1 70  GLU n 
1 71  LEU n 
1 72  ARG n 
1 73  GLY n 
1 74  PHE n 
1 75  LEU n 
1 76  ARG n 
1 77  HIS n 
1 78  TYR n 
1 79  GLU n 
1 80  GLU n 
1 81  ALA n 
1 82  THR n 
1 83  ARG n 
1 84  ALA n 
1 85  GLY n 
1 86  ILE n 
1 87  ARG n 
1 88  VAL n 
1 89  ASP n 
1 90  ASN n 
1 91  VAL n 
1 92  ARG n 
1 93  PRO n 
1 94  ARG n 
1 95  TRP n 
1 96  ASP n 
1 97  PHE n 
1 98  THR n 
1 99  GLY n 
1 100 ALA n 
1 101 PHE n 
1 102 TYR n 
1 103 PHE n 
1 104 VAL n 
1 105 GLY n 
1 106 THR n 
1 107 VAL n 
1 108 VAL n 
1 109 SER n 
1 110 THR n 
1 111 ILE n 
1 112 GLY n 
1 113 PHE n 
1 114 GLY n 
1 115 MET n 
1 116 THR n 
1 117 THR n 
1 118 PRO n 
1 119 ALA n 
1 120 THR n 
1 121 VAL n 
1 122 GLY n 
1 123 GLY n 
1 124 LYS n 
1 125 ILE n 
1 126 PHE n 
1 127 LEU n 
1 128 ILE n 
1 129 PHE n 
1 130 TYR n 
1 131 GLY n 
1 132 LEU n 
1 133 VAL n 
1 134 GLY n 
1 135 CYS n 
1 136 PRO n 
1 137 SER n 
1 138 THR n 
1 139 ILE n 
1 140 LEU n 
1 141 PHE n 
1 142 PHE n 
1 143 ASN n 
1 144 LEU n 
1 145 PHE n 
1 146 LEU n 
1 147 GLU n 
1 148 ARG n 
1 149 LEU n 
1 150 ILE n 
1 151 THR n 
1 152 ILE n 
1 153 ILE n 
1 154 ALA n 
1 155 TYR n 
1 156 ILE n 
1 157 MET n 
1 158 LYS n 
1 159 SER n 
1 160 CYS n 
1 161 HIS n 
1 162 GLN n 
1 163 ARG n 
1 164 GLN n 
1 165 LEU n 
1 166 ARG n 
1 167 ARG n 
1 168 ARG n 
1 169 GLY n 
1 170 ALA n 
1 171 LEU n 
1 172 PRO n 
1 173 GLN n 
1 174 GLU n 
1 175 SER n 
1 176 LEU n 
1 177 LYS n 
1 178 ASP n 
1 179 ALA n 
1 180 GLY n 
1 181 GLN n 
1 182 CYS n 
1 183 GLU n 
1 184 VAL n 
1 185 ASP n 
1 186 SER n 
1 187 LEU n 
1 188 ALA n 
1 189 GLY n 
1 190 TRP n 
1 191 LYS n 
1 192 PRO n 
1 193 SER n 
1 194 VAL n 
1 195 TYR n 
1 196 TYR n 
1 197 VAL n 
1 198 MET n 
1 199 LEU n 
1 200 ILE n 
1 201 LEU n 
1 202 CYS n 
1 203 THR n 
1 204 ALA n 
1 205 SER n 
1 206 ILE n 
1 207 LEU n 
1 208 ILE n 
1 209 SER n 
1 210 CYS n 
1 211 CYS n 
1 212 ALA n 
1 213 SER n 
1 214 ALA n 
1 215 MET n 
1 216 TYR n 
1 217 THR n 
1 218 PRO n 
1 219 ILE n 
1 220 GLU n 
1 221 GLY n 
1 222 TRP n 
1 223 SER n 
1 224 TYR n 
1 225 PHE n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 PHE n 
1 231 CYS n 
1 232 PHE n 
1 233 VAL n 
1 234 ALA n 
1 235 PHE n 
1 236 SER n 
1 237 THR n 
1 238 ILE n 
1 239 GLY n 
1 240 PHE n 
1 241 GLY n 
1 242 ASP n 
1 243 LEU n 
1 244 VAL n 
1 245 SER n 
1 246 SER n 
1 247 GLN n 
1 248 ASN n 
1 249 ALA n 
1 250 HIS n 
1 251 TYR n 
1 252 GLU n 
1 253 SER n 
1 254 GLN n 
1 255 GLY n 
1 256 LEU n 
1 257 TYR n 
1 258 ARG n 
1 259 PHE n 
1 260 ALA n 
1 261 ASN n 
1 262 PHE n 
1 263 VAL n 
1 264 PHE n 
1 265 ILE n 
1 266 LEU n 
1 267 MET n 
1 268 GLY n 
1 269 VAL n 
1 270 CYS n 
1 271 CYS n 
1 272 ILE n 
1 273 TYR n 
1 274 SER n 
1 275 LEU n 
1 276 PHE n 
1 277 ASN n 
1 278 VAL n 
1 279 ILE n 
1 280 SER n 
1 281 ILE n 
1 282 LEU n 
1 283 ILE n 
1 284 LYS n 
1 285 GLN n 
1 286 SER n 
1 287 LEU n 
1 288 ASN n 
1 289 TRP n 
1 290 ILE n 
1 291 LEU n 
1 292 ARG n 
1 293 LYS n 
1 294 MET n 
1 295 ASP n 
1 296 SER n 
1 297 GLY n 
1 298 CYS n 
1 299 CYS n 
1 300 PRO n 
1 301 GLN n 
1 302 CYS n 
1 303 GLN n 
1 304 ARG n 
1 305 GLY n 
1 306 LEU n 
1 307 LEU n 
1 308 ARG n 
1 309 SER n 
1 310 ARG n 
1 311 ARG n 
1 312 ASN n 
1 313 VAL n 
1 314 VAL n 
1 315 MET n 
1 316 PRO n 
1 317 GLY n 
1 318 SER n 
1 319 VAL n 
1 320 ARG n 
1 321 ASN n 
1 322 ARG n 
1 323 CYS n 
1 324 ASN n 
1 325 ILE n 
1 326 SER n 
1 327 ILE n 
1 328 GLU n 
1 329 THR n 
1 330 ASP n 
1 331 GLY n 
1 332 VAL n 
1 333 ALA n 
1 334 GLU n 
1 335 SER n 
1 336 ASP n 
1 337 THR n 
1 338 ASP n 
1 339 GLY n 
1 340 ARG n 
1 341 ARG n 
1 342 LEU n 
1 343 SER n 
1 344 GLY n 
1 345 GLU n 
1 346 MET n 
1 347 ILE n 
1 348 SER n 
1 349 MET n 
1 350 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   350 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 KCNK13 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               human 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                    'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                    'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                    'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                    'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                    'C3 H7 N O2 S'   121.158 
D10 non-polymer         . DECANE          ?                    'C10 H22'        142.282 
D12 non-polymer         . DODECANE        ?                    'C12 H26'        170.335 
EIC non-polymer         . 'LINOLEIC ACID' '9,12-LINOLEIC ACID' 'C18 H32 O2'     280.445 
GLN 'L-peptide linking' y GLUTAMINE       ?                    'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                    'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                    'C2 H5 N O2'     75.067  
HEX non-polymer         . HEXANE          ?                    'C6 H14'         86.175  
HIS 'L-peptide linking' y HISTIDINE       ?                    'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ?                    'C6 H13 N O2'    131.173 
K   non-polymer         . 'POTASSIUM ION' ?                    'K 1'            39.098  
LEU 'L-peptide linking' y LEUCINE         ?                    'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                    'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                    'C5 H11 N O2 S'  149.211 
OCT non-polymer         . N-OCTANE        ?                    'C8 H18'         114.229 
PHE 'L-peptide linking' y PHENYLALANINE   ?                    'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                    'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ?                    'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                    'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                    'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                    'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                    'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   U . n 
A 1 2   ALA 2   2   ?   ?   ?   U . n 
A 1 3   GLY 3   3   ?   ?   ?   U . n 
A 1 4   ARG 4   4   ?   ?   ?   U . n 
A 1 5   GLY 5   5   ?   ?   ?   U . n 
A 1 6   PHE 6   6   ?   ?   ?   U . n 
A 1 7   SER 7   7   ?   ?   ?   U . n 
A 1 8   TRP 8   8   ?   ?   ?   U . n 
A 1 9   GLY 9   9   ?   ?   ?   U . n 
A 1 10  PRO 10  10  ?   ?   ?   U . n 
A 1 11  GLY 11  11  ?   ?   ?   U . n 
A 1 12  HIS 12  12  ?   ?   ?   U . n 
A 1 13  LEU 13  13  ?   ?   ?   U . n 
A 1 14  ASN 14  14  14  ASN ASN U . n 
A 1 15  GLU 15  15  15  GLU GLU U . n 
A 1 16  ASP 16  16  16  ASP ASP U . n 
A 1 17  ASN 17  17  17  ASN ASN U . n 
A 1 18  ALA 18  18  18  ALA ALA U . n 
A 1 19  ARG 19  19  19  ARG ARG U . n 
A 1 20  PHE 20  20  20  PHE PHE U . n 
A 1 21  LEU 21  21  21  LEU LEU U . n 
A 1 22  LEU 22  22  22  LEU LEU U . n 
A 1 23  LEU 23  23  23  LEU LEU U . n 
A 1 24  ALA 24  24  24  ALA ALA U . n 
A 1 25  ALA 25  25  25  ALA ALA U . n 
A 1 26  LEU 26  26  26  LEU LEU U . n 
A 1 27  ILE 27  27  27  ILE ILE U . n 
A 1 28  VAL 28  28  28  VAL VAL U . n 
A 1 29  LEU 29  29  29  LEU LEU U . n 
A 1 30  TYR 30  30  30  TYR TYR U . n 
A 1 31  LEU 31  31  31  LEU LEU U . n 
A 1 32  LEU 32  32  32  LEU LEU U . n 
A 1 33  GLY 33  33  33  GLY GLY U . n 
A 1 34  GLY 34  34  34  GLY GLY U . n 
A 1 35  ALA 35  35  35  ALA ALA U . n 
A 1 36  ALA 36  36  36  ALA ALA U . n 
A 1 37  VAL 37  37  37  VAL VAL U . n 
A 1 38  PHE 38  38  38  PHE PHE U . n 
A 1 39  SER 39  39  39  SER SER U . n 
A 1 40  ALA 40  40  40  ALA ALA U . n 
A 1 41  LEU 41  41  41  LEU LEU U . n 
A 1 42  GLU 42  42  42  GLU GLU U . n 
A 1 43  LEU 43  43  43  LEU LEU U . n 
A 1 44  ALA 44  44  44  ALA ALA U . n 
A 1 45  HIS 45  45  45  HIS HIS U . n 
A 1 46  GLU 46  46  46  GLU GLU U . n 
A 1 47  ARG 47  47  47  ARG ARG U . n 
A 1 48  GLN 48  48  48  GLN GLN U . n 
A 1 49  ALA 49  49  49  ALA ALA U . n 
A 1 50  LYS 50  50  50  LYS LYS U . n 
A 1 51  GLN 51  51  51  GLN GLN U . n 
A 1 52  ARG 52  52  52  ARG ARG U . n 
A 1 53  TRP 53  53  53  TRP TRP U . n 
A 1 54  GLU 54  54  54  GLU GLU U . n 
A 1 55  GLU 55  55  55  GLU GLU U . n 
A 1 56  ARG 56  56  56  ARG ARG U . n 
A 1 57  LEU 57  57  57  LEU LEU U . n 
A 1 58  ALA 58  58  58  ALA ALA U . n 
A 1 59  GLN 59  59  59  GLN GLN U . n 
A 1 60  PHE 60  60  60  PHE PHE U . n 
A 1 61  SER 61  61  61  SER SER U . n 
A 1 62  ARG 62  62  62  ARG ARG U . n 
A 1 63  GLY 63  63  63  GLY GLY U . n 
A 1 64  HIS 64  64  64  HIS HIS U . n 
A 1 65  GLN 65  65  65  GLN GLN U . n 
A 1 66  LEU 66  66  66  LEU LEU U . n 
A 1 67  SER 67  67  67  SER SER U . n 
A 1 68  ARG 68  68  68  ARG ARG U . n 
A 1 69  ASP 69  69  69  ASP ASP U . n 
A 1 70  GLU 70  70  70  GLU GLU U . n 
A 1 71  LEU 71  71  71  LEU LEU U . n 
A 1 72  ARG 72  72  72  ARG ARG U . n 
A 1 73  GLY 73  73  73  GLY GLY U . n 
A 1 74  PHE 74  74  74  PHE PHE U . n 
A 1 75  LEU 75  75  75  LEU LEU U . n 
A 1 76  ARG 76  76  76  ARG ARG U . n 
A 1 77  HIS 77  77  77  HIS HIS U . n 
A 1 78  TYR 78  78  78  TYR TYR U . n 
A 1 79  GLU 79  79  79  GLU GLU U . n 
A 1 80  GLU 80  80  80  GLU GLU U . n 
A 1 81  ALA 81  81  81  ALA ALA U . n 
A 1 82  THR 82  82  82  THR THR U . n 
A 1 83  ARG 83  83  83  ARG ARG U . n 
A 1 84  ALA 84  84  84  ALA ALA U . n 
A 1 85  GLY 85  85  85  GLY GLY U . n 
A 1 86  ILE 86  86  86  ILE ILE U . n 
A 1 87  ARG 87  87  87  ARG ARG U . n 
A 1 88  VAL 88  88  88  VAL VAL U . n 
A 1 89  ASP 89  89  89  ASP ASP U . n 
A 1 90  ASN 90  90  90  ASN ASN U . n 
A 1 91  VAL 91  91  91  VAL VAL U . n 
A 1 92  ARG 92  92  92  ARG ARG U . n 
A 1 93  PRO 93  93  93  PRO PRO U . n 
A 1 94  ARG 94  94  94  ARG ARG U . n 
A 1 95  TRP 95  95  95  TRP TRP U . n 
A 1 96  ASP 96  96  96  ASP ASP U . n 
A 1 97  PHE 97  97  97  PHE PHE U . n 
A 1 98  THR 98  98  98  THR THR U . n 
A 1 99  GLY 99  99  99  GLY GLY U . n 
A 1 100 ALA 100 100 100 ALA ALA U . n 
A 1 101 PHE 101 101 101 PHE PHE U . n 
A 1 102 TYR 102 102 102 TYR TYR U . n 
A 1 103 PHE 103 103 103 PHE PHE U . n 
A 1 104 VAL 104 104 104 VAL VAL U . n 
A 1 105 GLY 105 105 105 GLY GLY U . n 
A 1 106 THR 106 106 106 THR THR U . n 
A 1 107 VAL 107 107 107 VAL VAL U . n 
A 1 108 VAL 108 108 108 VAL VAL U . n 
A 1 109 SER 109 109 109 SER SER U . n 
A 1 110 THR 110 110 110 THR THR U . n 
A 1 111 ILE 111 111 111 ILE ILE U . n 
A 1 112 GLY 112 112 112 GLY GLY U . n 
A 1 113 PHE 113 113 113 PHE PHE U . n 
A 1 114 GLY 114 114 114 GLY GLY U . n 
A 1 115 MET 115 115 115 MET MET U . n 
A 1 116 THR 116 116 116 THR THR U . n 
A 1 117 THR 117 117 117 THR THR U . n 
A 1 118 PRO 118 118 118 PRO PRO U . n 
A 1 119 ALA 119 119 119 ALA ALA U . n 
A 1 120 THR 120 120 120 THR THR U . n 
A 1 121 VAL 121 121 121 VAL VAL U . n 
A 1 122 GLY 122 122 122 GLY GLY U . n 
A 1 123 GLY 123 123 123 GLY GLY U . n 
A 1 124 LYS 124 124 124 LYS LYS U . n 
A 1 125 ILE 125 125 125 ILE ILE U . n 
A 1 126 PHE 126 126 126 PHE PHE U . n 
A 1 127 LEU 127 127 127 LEU LEU U . n 
A 1 128 ILE 128 128 128 ILE ILE U . n 
A 1 129 PHE 129 129 129 PHE PHE U . n 
A 1 130 TYR 130 130 130 TYR TYR U . n 
A 1 131 GLY 131 131 131 GLY GLY U . n 
A 1 132 LEU 132 132 132 LEU LEU U . n 
A 1 133 VAL 133 133 133 VAL VAL U . n 
A 1 134 GLY 134 134 134 GLY GLY U . n 
A 1 135 CYS 135 135 135 CYS CYS U . n 
A 1 136 PRO 136 136 136 PRO PRO U . n 
A 1 137 SER 137 137 137 SER SER U . n 
A 1 138 THR 138 138 138 THR THR U . n 
A 1 139 ILE 139 139 139 ILE ILE U . n 
A 1 140 LEU 140 140 140 LEU LEU U . n 
A 1 141 PHE 141 141 141 PHE PHE U . n 
A 1 142 PHE 142 142 142 PHE PHE U . n 
A 1 143 ASN 143 143 143 ASN ASN U . n 
A 1 144 LEU 144 144 144 LEU LEU U . n 
A 1 145 PHE 145 145 145 PHE PHE U . n 
A 1 146 LEU 146 146 146 LEU LEU U . n 
A 1 147 GLU 147 147 147 GLU GLU U . n 
A 1 148 ARG 148 148 148 ARG ARG U . n 
A 1 149 LEU 149 149 149 LEU LEU U . n 
A 1 150 ILE 150 150 150 ILE ILE U . n 
A 1 151 THR 151 151 151 THR THR U . n 
A 1 152 ILE 152 152 152 ILE ILE U . n 
A 1 153 ILE 153 153 153 ILE ILE U . n 
A 1 154 ALA 154 154 154 ALA ALA U . n 
A 1 155 TYR 155 155 155 TYR TYR U . n 
A 1 156 ILE 156 156 156 ILE ILE U . n 
A 1 157 MET 157 157 157 MET MET U . n 
A 1 158 LYS 158 158 158 LYS LYS U . n 
A 1 159 SER 159 159 159 SER SER U . n 
A 1 160 CYS 160 160 160 CYS CYS U . n 
A 1 161 HIS 161 161 161 HIS HIS U . n 
A 1 162 GLN 162 162 162 GLN GLN U . n 
A 1 163 ARG 163 163 ?   ?   ?   U . n 
A 1 164 GLN 164 164 ?   ?   ?   U . n 
A 1 165 LEU 165 165 ?   ?   ?   U . n 
A 1 166 ARG 166 166 ?   ?   ?   U . n 
A 1 167 ARG 167 167 ?   ?   ?   U . n 
A 1 168 ARG 168 168 ?   ?   ?   U . n 
A 1 169 GLY 169 169 ?   ?   ?   U . n 
A 1 170 ALA 170 170 ?   ?   ?   U . n 
A 1 171 LEU 171 171 ?   ?   ?   U . n 
A 1 172 PRO 172 172 ?   ?   ?   U . n 
A 1 173 GLN 173 173 ?   ?   ?   U . n 
A 1 174 GLU 174 174 ?   ?   ?   U . n 
A 1 175 SER 175 175 ?   ?   ?   U . n 
A 1 176 LEU 176 176 ?   ?   ?   U . n 
A 1 177 LYS 177 177 ?   ?   ?   U . n 
A 1 178 ASP 178 178 ?   ?   ?   U . n 
A 1 179 ALA 179 179 ?   ?   ?   U . n 
A 1 180 GLY 180 180 ?   ?   ?   U . n 
A 1 181 GLN 181 181 ?   ?   ?   U . n 
A 1 182 CYS 182 182 ?   ?   ?   U . n 
A 1 183 GLU 183 183 ?   ?   ?   U . n 
A 1 184 VAL 184 184 ?   ?   ?   U . n 
A 1 185 ASP 185 185 ?   ?   ?   U . n 
A 1 186 SER 186 186 ?   ?   ?   U . n 
A 1 187 LEU 187 187 ?   ?   ?   U . n 
A 1 188 ALA 188 188 188 ALA ALA U . n 
A 1 189 GLY 189 189 189 GLY GLY U . n 
A 1 190 TRP 190 190 190 TRP TRP U . n 
A 1 191 LYS 191 191 191 LYS LYS U . n 
A 1 192 PRO 192 192 192 PRO PRO U . n 
A 1 193 SER 193 193 193 SER SER U . n 
A 1 194 VAL 194 194 194 VAL VAL U . n 
A 1 195 TYR 195 195 195 TYR TYR U . n 
A 1 196 TYR 196 196 196 TYR TYR U . n 
A 1 197 VAL 197 197 197 VAL VAL U . n 
A 1 198 MET 198 198 198 MET MET U . n 
A 1 199 LEU 199 199 199 LEU LEU U . n 
A 1 200 ILE 200 200 200 ILE ILE U . n 
A 1 201 LEU 201 201 201 LEU LEU U . n 
A 1 202 CYS 202 202 202 CYS CYS U . n 
A 1 203 THR 203 203 203 THR THR U . n 
A 1 204 ALA 204 204 204 ALA ALA U . n 
A 1 205 SER 205 205 205 SER SER U . n 
A 1 206 ILE 206 206 206 ILE ILE U . n 
A 1 207 LEU 207 207 207 LEU LEU U . n 
A 1 208 ILE 208 208 208 ILE ILE U . n 
A 1 209 SER 209 209 209 SER SER U . n 
A 1 210 CYS 210 210 210 CYS CYS U . n 
A 1 211 CYS 211 211 211 CYS CYS U . n 
A 1 212 ALA 212 212 212 ALA ALA U . n 
A 1 213 SER 213 213 213 SER SER U . n 
A 1 214 ALA 214 214 214 ALA ALA U . n 
A 1 215 MET 215 215 215 MET MET U . n 
A 1 216 TYR 216 216 216 TYR TYR U . n 
A 1 217 THR 217 217 217 THR THR U . n 
A 1 218 PRO 218 218 218 PRO PRO U . n 
A 1 219 ILE 219 219 219 ILE ILE U . n 
A 1 220 GLU 220 220 220 GLU GLU U . n 
A 1 221 GLY 221 221 221 GLY GLY U . n 
A 1 222 TRP 222 222 222 TRP TRP U . n 
A 1 223 SER 223 223 223 SER SER U . n 
A 1 224 TYR 224 224 224 TYR TYR U . n 
A 1 225 PHE 225 225 225 PHE PHE U . n 
A 1 226 ASP 226 226 226 ASP ASP U . n 
A 1 227 SER 227 227 227 SER SER U . n 
A 1 228 LEU 228 228 228 LEU LEU U . n 
A 1 229 TYR 229 229 229 TYR TYR U . n 
A 1 230 PHE 230 230 230 PHE PHE U . n 
A 1 231 CYS 231 231 231 CYS CYS U . n 
A 1 232 PHE 232 232 232 PHE PHE U . n 
A 1 233 VAL 233 233 233 VAL VAL U . n 
A 1 234 ALA 234 234 234 ALA ALA U . n 
A 1 235 PHE 235 235 235 PHE PHE U . n 
A 1 236 SER 236 236 236 SER SER U . n 
A 1 237 THR 237 237 237 THR THR U . n 
A 1 238 ILE 238 238 238 ILE ILE U . n 
A 1 239 GLY 239 239 239 GLY GLY U . n 
A 1 240 PHE 240 240 240 PHE PHE U . n 
A 1 241 GLY 241 241 241 GLY GLY U . n 
A 1 242 ASP 242 242 242 ASP ASP U . n 
A 1 243 LEU 243 243 243 LEU LEU U . n 
A 1 244 VAL 244 244 244 VAL VAL U . n 
A 1 245 SER 245 245 245 SER SER U . n 
A 1 246 SER 246 246 246 SER SER U . n 
A 1 247 GLN 247 247 247 GLN GLN U . n 
A 1 248 ASN 248 248 248 ASN ASN U . n 
A 1 249 ALA 249 249 249 ALA ALA U . n 
A 1 250 HIS 250 250 250 HIS HIS U . n 
A 1 251 TYR 251 251 251 TYR TYR U . n 
A 1 252 GLU 252 252 252 GLU GLU U . n 
A 1 253 SER 253 253 253 SER SER U . n 
A 1 254 GLN 254 254 254 GLN GLN U . n 
A 1 255 GLY 255 255 255 GLY GLY U . n 
A 1 256 LEU 256 256 256 LEU LEU U . n 
A 1 257 TYR 257 257 257 TYR TYR U . n 
A 1 258 ARG 258 258 258 ARG ARG U . n 
A 1 259 PHE 259 259 259 PHE PHE U . n 
A 1 260 ALA 260 260 260 ALA ALA U . n 
A 1 261 ASN 261 261 261 ASN ASN U . n 
A 1 262 PHE 262 262 262 PHE PHE U . n 
A 1 263 VAL 263 263 263 VAL VAL U . n 
A 1 264 PHE 264 264 264 PHE PHE U . n 
A 1 265 ILE 265 265 265 ILE ILE U . n 
A 1 266 LEU 266 266 266 LEU LEU U . n 
A 1 267 MET 267 267 267 MET MET U . n 
A 1 268 GLY 268 268 268 GLY GLY U . n 
A 1 269 VAL 269 269 269 VAL VAL U . n 
A 1 270 CYS 270 270 270 CYS CYS U . n 
A 1 271 CYS 271 271 271 CYS CYS U . n 
A 1 272 ILE 272 272 272 ILE ILE U . n 
A 1 273 TYR 273 273 273 TYR TYR U . n 
A 1 274 SER 274 274 274 SER SER U . n 
A 1 275 LEU 275 275 275 LEU LEU U . n 
A 1 276 PHE 276 276 276 PHE PHE U . n 
A 1 277 ASN 277 277 277 ASN ASN U . n 
A 1 278 VAL 278 278 278 VAL VAL U . n 
A 1 279 ILE 279 279 279 ILE ILE U . n 
A 1 280 SER 280 280 280 SER SER U . n 
A 1 281 ILE 281 281 281 ILE ILE U . n 
A 1 282 LEU 282 282 282 LEU LEU U . n 
A 1 283 ILE 283 283 283 ILE ILE U . n 
A 1 284 LYS 284 284 284 LYS LYS U . n 
A 1 285 GLN 285 285 285 GLN GLN U . n 
A 1 286 SER 286 286 286 SER SER U . n 
A 1 287 LEU 287 287 287 LEU LEU U . n 
A 1 288 ASN 288 288 288 ASN ASN U . n 
A 1 289 TRP 289 289 289 TRP TRP U . n 
A 1 290 ILE 290 290 290 ILE ILE U . n 
A 1 291 LEU 291 291 291 LEU LEU U . n 
A 1 292 ARG 292 292 292 ARG ARG U . n 
A 1 293 LYS 293 293 293 LYS LYS U . n 
A 1 294 MET 294 294 294 MET MET U . n 
A 1 295 ASP 295 295 295 ASP ASP U . n 
A 1 296 SER 296 296 ?   ?   ?   U . n 
A 1 297 GLY 297 297 ?   ?   ?   U . n 
A 1 298 CYS 298 298 ?   ?   ?   U . n 
A 1 299 CYS 299 299 ?   ?   ?   U . n 
A 1 300 PRO 300 300 ?   ?   ?   U . n 
A 1 301 GLN 301 301 ?   ?   ?   U . n 
A 1 302 CYS 302 302 ?   ?   ?   U . n 
A 1 303 GLN 303 303 ?   ?   ?   U . n 
A 1 304 ARG 304 304 ?   ?   ?   U . n 
A 1 305 GLY 305 305 ?   ?   ?   U . n 
A 1 306 LEU 306 306 ?   ?   ?   U . n 
A 1 307 LEU 307 307 ?   ?   ?   U . n 
A 1 308 ARG 308 308 ?   ?   ?   U . n 
A 1 309 SER 309 309 ?   ?   ?   U . n 
A 1 310 ARG 310 310 ?   ?   ?   U . n 
A 1 311 ARG 311 311 ?   ?   ?   U . n 
A 1 312 ASN 312 312 ?   ?   ?   U . n 
A 1 313 VAL 313 313 ?   ?   ?   U . n 
A 1 314 VAL 314 314 ?   ?   ?   U . n 
A 1 315 MET 315 315 ?   ?   ?   U . n 
A 1 316 PRO 316 316 ?   ?   ?   U . n 
A 1 317 GLY 317 317 ?   ?   ?   U . n 
A 1 318 SER 318 318 ?   ?   ?   U . n 
A 1 319 VAL 319 319 ?   ?   ?   U . n 
A 1 320 ARG 320 320 ?   ?   ?   U . n 
A 1 321 ASN 321 321 ?   ?   ?   U . n 
A 1 322 ARG 322 322 ?   ?   ?   U . n 
A 1 323 CYS 323 323 ?   ?   ?   U . n 
A 1 324 ASN 324 324 ?   ?   ?   U . n 
A 1 325 ILE 325 325 ?   ?   ?   U . n 
A 1 326 SER 326 326 ?   ?   ?   U . n 
A 1 327 ILE 327 327 ?   ?   ?   U . n 
A 1 328 GLU 328 328 ?   ?   ?   U . n 
A 1 329 THR 329 329 ?   ?   ?   U . n 
A 1 330 ASP 330 330 ?   ?   ?   U . n 
A 1 331 GLY 331 331 ?   ?   ?   U . n 
A 1 332 VAL 332 332 ?   ?   ?   U . n 
A 1 333 ALA 333 333 ?   ?   ?   U . n 
A 1 334 GLU 334 334 ?   ?   ?   U . n 
A 1 335 SER 335 335 ?   ?   ?   U . n 
A 1 336 ASP 336 336 ?   ?   ?   U . n 
A 1 337 THR 337 337 ?   ?   ?   U . n 
A 1 338 ASP 338 338 ?   ?   ?   U . n 
A 1 339 GLY 339 339 ?   ?   ?   U . n 
A 1 340 ARG 340 340 ?   ?   ?   U . n 
A 1 341 ARG 341 341 ?   ?   ?   U . n 
A 1 342 LEU 342 342 ?   ?   ?   U . n 
A 1 343 SER 343 343 ?   ?   ?   U . n 
A 1 344 GLY 344 344 ?   ?   ?   U . n 
A 1 345 GLU 345 345 ?   ?   ?   U . n 
A 1 346 MET 346 346 ?   ?   ?   U . n 
A 1 347 ILE 347 347 ?   ?   ?   U . n 
A 1 348 SER 348 348 ?   ?   ?   U . n 
A 1 349 MET 349 349 ?   ?   ?   U . n 
A 1 350 LYS 350 350 ?   ?   ?   U . n 
B 1 1   MET 1   1   ?   ?   ?   A . n 
B 1 2   ALA 2   2   ?   ?   ?   A . n 
B 1 3   GLY 3   3   ?   ?   ?   A . n 
B 1 4   ARG 4   4   ?   ?   ?   A . n 
B 1 5   GLY 5   5   ?   ?   ?   A . n 
B 1 6   PHE 6   6   ?   ?   ?   A . n 
B 1 7   SER 7   7   ?   ?   ?   A . n 
B 1 8   TRP 8   8   ?   ?   ?   A . n 
B 1 9   GLY 9   9   ?   ?   ?   A . n 
B 1 10  PRO 10  10  ?   ?   ?   A . n 
B 1 11  GLY 11  11  ?   ?   ?   A . n 
B 1 12  HIS 12  12  ?   ?   ?   A . n 
B 1 13  LEU 13  13  ?   ?   ?   A . n 
B 1 14  ASN 14  14  14  ASN ASN A . n 
B 1 15  GLU 15  15  15  GLU GLU A . n 
B 1 16  ASP 16  16  16  ASP ASP A . n 
B 1 17  ASN 17  17  17  ASN ASN A . n 
B 1 18  ALA 18  18  18  ALA ALA A . n 
B 1 19  ARG 19  19  19  ARG ARG A . n 
B 1 20  PHE 20  20  20  PHE PHE A . n 
B 1 21  LEU 21  21  21  LEU LEU A . n 
B 1 22  LEU 22  22  22  LEU LEU A . n 
B 1 23  LEU 23  23  23  LEU LEU A . n 
B 1 24  ALA 24  24  24  ALA ALA A . n 
B 1 25  ALA 25  25  25  ALA ALA A . n 
B 1 26  LEU 26  26  26  LEU LEU A . n 
B 1 27  ILE 27  27  27  ILE ILE A . n 
B 1 28  VAL 28  28  28  VAL VAL A . n 
B 1 29  LEU 29  29  29  LEU LEU A . n 
B 1 30  TYR 30  30  30  TYR TYR A . n 
B 1 31  LEU 31  31  31  LEU LEU A . n 
B 1 32  LEU 32  32  32  LEU LEU A . n 
B 1 33  GLY 33  33  33  GLY GLY A . n 
B 1 34  GLY 34  34  34  GLY GLY A . n 
B 1 35  ALA 35  35  35  ALA ALA A . n 
B 1 36  ALA 36  36  36  ALA ALA A . n 
B 1 37  VAL 37  37  37  VAL VAL A . n 
B 1 38  PHE 38  38  38  PHE PHE A . n 
B 1 39  SER 39  39  39  SER SER A . n 
B 1 40  ALA 40  40  40  ALA ALA A . n 
B 1 41  LEU 41  41  41  LEU LEU A . n 
B 1 42  GLU 42  42  42  GLU GLU A . n 
B 1 43  LEU 43  43  43  LEU LEU A . n 
B 1 44  ALA 44  44  44  ALA ALA A . n 
B 1 45  HIS 45  45  45  HIS HIS A . n 
B 1 46  GLU 46  46  46  GLU GLU A . n 
B 1 47  ARG 47  47  47  ARG ARG A . n 
B 1 48  GLN 48  48  48  GLN GLN A . n 
B 1 49  ALA 49  49  49  ALA ALA A . n 
B 1 50  LYS 50  50  50  LYS LYS A . n 
B 1 51  GLN 51  51  51  GLN GLN A . n 
B 1 52  ARG 52  52  52  ARG ARG A . n 
B 1 53  TRP 53  53  53  TRP TRP A . n 
B 1 54  GLU 54  54  54  GLU GLU A . n 
B 1 55  GLU 55  55  55  GLU GLU A . n 
B 1 56  ARG 56  56  56  ARG ARG A . n 
B 1 57  LEU 57  57  57  LEU LEU A . n 
B 1 58  ALA 58  58  58  ALA ALA A . n 
B 1 59  GLN 59  59  59  GLN GLN A . n 
B 1 60  PHE 60  60  60  PHE PHE A . n 
B 1 61  SER 61  61  61  SER SER A . n 
B 1 62  ARG 62  62  62  ARG ARG A . n 
B 1 63  GLY 63  63  63  GLY GLY A . n 
B 1 64  HIS 64  64  64  HIS HIS A . n 
B 1 65  GLN 65  65  65  GLN GLN A . n 
B 1 66  LEU 66  66  66  LEU LEU A . n 
B 1 67  SER 67  67  67  SER SER A . n 
B 1 68  ARG 68  68  68  ARG ARG A . n 
B 1 69  ASP 69  69  69  ASP ASP A . n 
B 1 70  GLU 70  70  70  GLU GLU A . n 
B 1 71  LEU 71  71  71  LEU LEU A . n 
B 1 72  ARG 72  72  72  ARG ARG A . n 
B 1 73  GLY 73  73  73  GLY GLY A . n 
B 1 74  PHE 74  74  74  PHE PHE A . n 
B 1 75  LEU 75  75  75  LEU LEU A . n 
B 1 76  ARG 76  76  76  ARG ARG A . n 
B 1 77  HIS 77  77  77  HIS HIS A . n 
B 1 78  TYR 78  78  78  TYR TYR A . n 
B 1 79  GLU 79  79  79  GLU GLU A . n 
B 1 80  GLU 80  80  80  GLU GLU A . n 
B 1 81  ALA 81  81  81  ALA ALA A . n 
B 1 82  THR 82  82  82  THR THR A . n 
B 1 83  ARG 83  83  83  ARG ARG A . n 
B 1 84  ALA 84  84  84  ALA ALA A . n 
B 1 85  GLY 85  85  85  GLY GLY A . n 
B 1 86  ILE 86  86  86  ILE ILE A . n 
B 1 87  ARG 87  87  87  ARG ARG A . n 
B 1 88  VAL 88  88  88  VAL VAL A . n 
B 1 89  ASP 89  89  89  ASP ASP A . n 
B 1 90  ASN 90  90  90  ASN ASN A . n 
B 1 91  VAL 91  91  91  VAL VAL A . n 
B 1 92  ARG 92  92  92  ARG ARG A . n 
B 1 93  PRO 93  93  93  PRO PRO A . n 
B 1 94  ARG 94  94  94  ARG ARG A . n 
B 1 95  TRP 95  95  95  TRP TRP A . n 
B 1 96  ASP 96  96  96  ASP ASP A . n 
B 1 97  PHE 97  97  97  PHE PHE A . n 
B 1 98  THR 98  98  98  THR THR A . n 
B 1 99  GLY 99  99  99  GLY GLY A . n 
B 1 100 ALA 100 100 100 ALA ALA A . n 
B 1 101 PHE 101 101 101 PHE PHE A . n 
B 1 102 TYR 102 102 102 TYR TYR A . n 
B 1 103 PHE 103 103 103 PHE PHE A . n 
B 1 104 VAL 104 104 104 VAL VAL A . n 
B 1 105 GLY 105 105 105 GLY GLY A . n 
B 1 106 THR 106 106 106 THR THR A . n 
B 1 107 VAL 107 107 107 VAL VAL A . n 
B 1 108 VAL 108 108 108 VAL VAL A . n 
B 1 109 SER 109 109 109 SER SER A . n 
B 1 110 THR 110 110 110 THR THR A . n 
B 1 111 ILE 111 111 111 ILE ILE A . n 
B 1 112 GLY 112 112 112 GLY GLY A . n 
B 1 113 PHE 113 113 113 PHE PHE A . n 
B 1 114 GLY 114 114 114 GLY GLY A . n 
B 1 115 MET 115 115 115 MET MET A . n 
B 1 116 THR 116 116 116 THR THR A . n 
B 1 117 THR 117 117 117 THR THR A . n 
B 1 118 PRO 118 118 118 PRO PRO A . n 
B 1 119 ALA 119 119 119 ALA ALA A . n 
B 1 120 THR 120 120 120 THR THR A . n 
B 1 121 VAL 121 121 121 VAL VAL A . n 
B 1 122 GLY 122 122 122 GLY GLY A . n 
B 1 123 GLY 123 123 123 GLY GLY A . n 
B 1 124 LYS 124 124 124 LYS LYS A . n 
B 1 125 ILE 125 125 125 ILE ILE A . n 
B 1 126 PHE 126 126 126 PHE PHE A . n 
B 1 127 LEU 127 127 127 LEU LEU A . n 
B 1 128 ILE 128 128 128 ILE ILE A . n 
B 1 129 PHE 129 129 129 PHE PHE A . n 
B 1 130 TYR 130 130 130 TYR TYR A . n 
B 1 131 GLY 131 131 131 GLY GLY A . n 
B 1 132 LEU 132 132 132 LEU LEU A . n 
B 1 133 VAL 133 133 133 VAL VAL A . n 
B 1 134 GLY 134 134 134 GLY GLY A . n 
B 1 135 CYS 135 135 135 CYS CYS A . n 
B 1 136 PRO 136 136 136 PRO PRO A . n 
B 1 137 SER 137 137 137 SER SER A . n 
B 1 138 THR 138 138 138 THR THR A . n 
B 1 139 ILE 139 139 139 ILE ILE A . n 
B 1 140 LEU 140 140 140 LEU LEU A . n 
B 1 141 PHE 141 141 141 PHE PHE A . n 
B 1 142 PHE 142 142 142 PHE PHE A . n 
B 1 143 ASN 143 143 143 ASN ASN A . n 
B 1 144 LEU 144 144 144 LEU LEU A . n 
B 1 145 PHE 145 145 145 PHE PHE A . n 
B 1 146 LEU 146 146 146 LEU LEU A . n 
B 1 147 GLU 147 147 147 GLU GLU A . n 
B 1 148 ARG 148 148 148 ARG ARG A . n 
B 1 149 LEU 149 149 149 LEU LEU A . n 
B 1 150 ILE 150 150 150 ILE ILE A . n 
B 1 151 THR 151 151 151 THR THR A . n 
B 1 152 ILE 152 152 152 ILE ILE A . n 
B 1 153 ILE 153 153 153 ILE ILE A . n 
B 1 154 ALA 154 154 154 ALA ALA A . n 
B 1 155 TYR 155 155 155 TYR TYR A . n 
B 1 156 ILE 156 156 156 ILE ILE A . n 
B 1 157 MET 157 157 157 MET MET A . n 
B 1 158 LYS 158 158 158 LYS LYS A . n 
B 1 159 SER 159 159 159 SER SER A . n 
B 1 160 CYS 160 160 160 CYS CYS A . n 
B 1 161 HIS 161 161 161 HIS HIS A . n 
B 1 162 GLN 162 162 162 GLN GLN A . n 
B 1 163 ARG 163 163 ?   ?   ?   A . n 
B 1 164 GLN 164 164 ?   ?   ?   A . n 
B 1 165 LEU 165 165 ?   ?   ?   A . n 
B 1 166 ARG 166 166 ?   ?   ?   A . n 
B 1 167 ARG 167 167 ?   ?   ?   A . n 
B 1 168 ARG 168 168 ?   ?   ?   A . n 
B 1 169 GLY 169 169 ?   ?   ?   A . n 
B 1 170 ALA 170 170 ?   ?   ?   A . n 
B 1 171 LEU 171 171 ?   ?   ?   A . n 
B 1 172 PRO 172 172 ?   ?   ?   A . n 
B 1 173 GLN 173 173 ?   ?   ?   A . n 
B 1 174 GLU 174 174 ?   ?   ?   A . n 
B 1 175 SER 175 175 ?   ?   ?   A . n 
B 1 176 LEU 176 176 ?   ?   ?   A . n 
B 1 177 LYS 177 177 ?   ?   ?   A . n 
B 1 178 ASP 178 178 ?   ?   ?   A . n 
B 1 179 ALA 179 179 ?   ?   ?   A . n 
B 1 180 GLY 180 180 ?   ?   ?   A . n 
B 1 181 GLN 181 181 ?   ?   ?   A . n 
B 1 182 CYS 182 182 ?   ?   ?   A . n 
B 1 183 GLU 183 183 ?   ?   ?   A . n 
B 1 184 VAL 184 184 ?   ?   ?   A . n 
B 1 185 ASP 185 185 ?   ?   ?   A . n 
B 1 186 SER 186 186 ?   ?   ?   A . n 
B 1 187 LEU 187 187 ?   ?   ?   A . n 
B 1 188 ALA 188 188 188 ALA ALA A . n 
B 1 189 GLY 189 189 189 GLY GLY A . n 
B 1 190 TRP 190 190 190 TRP TRP A . n 
B 1 191 LYS 191 191 191 LYS LYS A . n 
B 1 192 PRO 192 192 192 PRO PRO A . n 
B 1 193 SER 193 193 193 SER SER A . n 
B 1 194 VAL 194 194 194 VAL VAL A . n 
B 1 195 TYR 195 195 195 TYR TYR A . n 
B 1 196 TYR 196 196 196 TYR TYR A . n 
B 1 197 VAL 197 197 197 VAL VAL A . n 
B 1 198 MET 198 198 198 MET MET A . n 
B 1 199 LEU 199 199 199 LEU LEU A . n 
B 1 200 ILE 200 200 200 ILE ILE A . n 
B 1 201 LEU 201 201 201 LEU LEU A . n 
B 1 202 CYS 202 202 202 CYS CYS A . n 
B 1 203 THR 203 203 203 THR THR A . n 
B 1 204 ALA 204 204 204 ALA ALA A . n 
B 1 205 SER 205 205 205 SER SER A . n 
B 1 206 ILE 206 206 206 ILE ILE A . n 
B 1 207 LEU 207 207 207 LEU LEU A . n 
B 1 208 ILE 208 208 208 ILE ILE A . n 
B 1 209 SER 209 209 209 SER SER A . n 
B 1 210 CYS 210 210 210 CYS CYS A . n 
B 1 211 CYS 211 211 211 CYS CYS A . n 
B 1 212 ALA 212 212 212 ALA ALA A . n 
B 1 213 SER 213 213 213 SER SER A . n 
B 1 214 ALA 214 214 214 ALA ALA A . n 
B 1 215 MET 215 215 215 MET MET A . n 
B 1 216 TYR 216 216 216 TYR TYR A . n 
B 1 217 THR 217 217 217 THR THR A . n 
B 1 218 PRO 218 218 218 PRO PRO A . n 
B 1 219 ILE 219 219 219 ILE ILE A . n 
B 1 220 GLU 220 220 220 GLU GLU A . n 
B 1 221 GLY 221 221 221 GLY GLY A . n 
B 1 222 TRP 222 222 222 TRP TRP A . n 
B 1 223 SER 223 223 223 SER SER A . n 
B 1 224 TYR 224 224 224 TYR TYR A . n 
B 1 225 PHE 225 225 225 PHE PHE A . n 
B 1 226 ASP 226 226 226 ASP ASP A . n 
B 1 227 SER 227 227 227 SER SER A . n 
B 1 228 LEU 228 228 228 LEU LEU A . n 
B 1 229 TYR 229 229 229 TYR TYR A . n 
B 1 230 PHE 230 230 230 PHE PHE A . n 
B 1 231 CYS 231 231 231 CYS CYS A . n 
B 1 232 PHE 232 232 232 PHE PHE A . n 
B 1 233 VAL 233 233 233 VAL VAL A . n 
B 1 234 ALA 234 234 234 ALA ALA A . n 
B 1 235 PHE 235 235 235 PHE PHE A . n 
B 1 236 SER 236 236 236 SER SER A . n 
B 1 237 THR 237 237 237 THR THR A . n 
B 1 238 ILE 238 238 238 ILE ILE A . n 
B 1 239 GLY 239 239 239 GLY GLY A . n 
B 1 240 PHE 240 240 240 PHE PHE A . n 
B 1 241 GLY 241 241 241 GLY GLY A . n 
B 1 242 ASP 242 242 242 ASP ASP A . n 
B 1 243 LEU 243 243 243 LEU LEU A . n 
B 1 244 VAL 244 244 244 VAL VAL A . n 
B 1 245 SER 245 245 245 SER SER A . n 
B 1 246 SER 246 246 246 SER SER A . n 
B 1 247 GLN 247 247 247 GLN GLN A . n 
B 1 248 ASN 248 248 248 ASN ASN A . n 
B 1 249 ALA 249 249 249 ALA ALA A . n 
B 1 250 HIS 250 250 250 HIS HIS A . n 
B 1 251 TYR 251 251 251 TYR TYR A . n 
B 1 252 GLU 252 252 252 GLU GLU A . n 
B 1 253 SER 253 253 253 SER SER A . n 
B 1 254 GLN 254 254 254 GLN GLN A . n 
B 1 255 GLY 255 255 255 GLY GLY A . n 
B 1 256 LEU 256 256 256 LEU LEU A . n 
B 1 257 TYR 257 257 257 TYR TYR A . n 
B 1 258 ARG 258 258 258 ARG ARG A . n 
B 1 259 PHE 259 259 259 PHE PHE A . n 
B 1 260 ALA 260 260 260 ALA ALA A . n 
B 1 261 ASN 261 261 261 ASN ASN A . n 
B 1 262 PHE 262 262 262 PHE PHE A . n 
B 1 263 VAL 263 263 263 VAL VAL A . n 
B 1 264 PHE 264 264 264 PHE PHE A . n 
B 1 265 ILE 265 265 265 ILE ILE A . n 
B 1 266 LEU 266 266 266 LEU LEU A . n 
B 1 267 MET 267 267 267 MET MET A . n 
B 1 268 GLY 268 268 268 GLY GLY A . n 
B 1 269 VAL 269 269 269 VAL VAL A . n 
B 1 270 CYS 270 270 270 CYS CYS A . n 
B 1 271 CYS 271 271 271 CYS CYS A . n 
B 1 272 ILE 272 272 272 ILE ILE A . n 
B 1 273 TYR 273 273 273 TYR TYR A . n 
B 1 274 SER 274 274 274 SER SER A . n 
B 1 275 LEU 275 275 275 LEU LEU A . n 
B 1 276 PHE 276 276 276 PHE PHE A . n 
B 1 277 ASN 277 277 277 ASN ASN A . n 
B 1 278 VAL 278 278 278 VAL VAL A . n 
B 1 279 ILE 279 279 279 ILE ILE A . n 
B 1 280 SER 280 280 280 SER SER A . n 
B 1 281 ILE 281 281 281 ILE ILE A . n 
B 1 282 LEU 282 282 282 LEU LEU A . n 
B 1 283 ILE 283 283 283 ILE ILE A . n 
B 1 284 LYS 284 284 284 LYS LYS A . n 
B 1 285 GLN 285 285 285 GLN GLN A . n 
B 1 286 SER 286 286 286 SER SER A . n 
B 1 287 LEU 287 287 287 LEU LEU A . n 
B 1 288 ASN 288 288 288 ASN ASN A . n 
B 1 289 TRP 289 289 289 TRP TRP A . n 
B 1 290 ILE 290 290 290 ILE ILE A . n 
B 1 291 LEU 291 291 291 LEU LEU A . n 
B 1 292 ARG 292 292 292 ARG ARG A . n 
B 1 293 LYS 293 293 293 LYS LYS A . n 
B 1 294 MET 294 294 294 MET MET A . n 
B 1 295 ASP 295 295 295 ASP ASP A . n 
B 1 296 SER 296 296 ?   ?   ?   A . n 
B 1 297 GLY 297 297 ?   ?   ?   A . n 
B 1 298 CYS 298 298 ?   ?   ?   A . n 
B 1 299 CYS 299 299 ?   ?   ?   A . n 
B 1 300 PRO 300 300 ?   ?   ?   A . n 
B 1 301 GLN 301 301 ?   ?   ?   A . n 
B 1 302 CYS 302 302 ?   ?   ?   A . n 
B 1 303 GLN 303 303 ?   ?   ?   A . n 
B 1 304 ARG 304 304 ?   ?   ?   A . n 
B 1 305 GLY 305 305 ?   ?   ?   A . n 
B 1 306 LEU 306 306 ?   ?   ?   A . n 
B 1 307 LEU 307 307 ?   ?   ?   A . n 
B 1 308 ARG 308 308 ?   ?   ?   A . n 
B 1 309 SER 309 309 ?   ?   ?   A . n 
B 1 310 ARG 310 310 ?   ?   ?   A . n 
B 1 311 ARG 311 311 ?   ?   ?   A . n 
B 1 312 ASN 312 312 ?   ?   ?   A . n 
B 1 313 VAL 313 313 ?   ?   ?   A . n 
B 1 314 VAL 314 314 ?   ?   ?   A . n 
B 1 315 MET 315 315 ?   ?   ?   A . n 
B 1 316 PRO 316 316 ?   ?   ?   A . n 
B 1 317 GLY 317 317 ?   ?   ?   A . n 
B 1 318 SER 318 318 ?   ?   ?   A . n 
B 1 319 VAL 319 319 ?   ?   ?   A . n 
B 1 320 ARG 320 320 ?   ?   ?   A . n 
B 1 321 ASN 321 321 ?   ?   ?   A . n 
B 1 322 ARG 322 322 ?   ?   ?   A . n 
B 1 323 CYS 323 323 ?   ?   ?   A . n 
B 1 324 ASN 324 324 ?   ?   ?   A . n 
B 1 325 ILE 325 325 ?   ?   ?   A . n 
B 1 326 SER 326 326 ?   ?   ?   A . n 
B 1 327 ILE 327 327 ?   ?   ?   A . n 
B 1 328 GLU 328 328 ?   ?   ?   A . n 
B 1 329 THR 329 329 ?   ?   ?   A . n 
B 1 330 ASP 330 330 ?   ?   ?   A . n 
B 1 331 GLY 331 331 ?   ?   ?   A . n 
B 1 332 VAL 332 332 ?   ?   ?   A . n 
B 1 333 ALA 333 333 ?   ?   ?   A . n 
B 1 334 GLU 334 334 ?   ?   ?   A . n 
B 1 335 SER 335 335 ?   ?   ?   A . n 
B 1 336 ASP 336 336 ?   ?   ?   A . n 
B 1 337 THR 337 337 ?   ?   ?   A . n 
B 1 338 ASP 338 338 ?   ?   ?   A . n 
B 1 339 GLY 339 339 ?   ?   ?   A . n 
B 1 340 ARG 340 340 ?   ?   ?   A . n 
B 1 341 ARG 341 341 ?   ?   ?   A . n 
B 1 342 LEU 342 342 ?   ?   ?   A . n 
B 1 343 SER 343 343 ?   ?   ?   A . n 
B 1 344 GLY 344 344 ?   ?   ?   A . n 
B 1 345 GLU 345 345 ?   ?   ?   A . n 
B 1 346 MET 346 346 ?   ?   ?   A . n 
B 1 347 ILE 347 347 ?   ?   ?   A . n 
B 1 348 SER 348 348 ?   ?   ?   A . n 
B 1 349 MET 349 349 ?   ?   ?   A . n 
B 1 350 LYS 350 350 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        EIC 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   EIC 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 D12 1 401 302 D12 D12 U . 
D 3 D10 1 402 303 D10 D10 U . 
E 4 OCT 1 403 304 OCT D08 U . 
F 4 OCT 1 404 306 OCT D08 U . 
G 3 D10 1 405 307 D10 D10 U . 
H 5 EIC 1 406 309 EIC EIC U . 
I 4 OCT 1 407 308 OCT D08 U . 
J 4 OCT 1 401 305 OCT D08 A . 
K 6 HEX 1 402 308 HEX D06 A . 
L 2 D12 1 403 302 D12 D12 A . 
M 3 D10 1 404 303 D10 D10 A . 
N 4 OCT 1 405 304 OCT D08 A . 
O 4 OCT 1 406 305 OCT D08 A . 
P 4 OCT 1 407 306 OCT D08 A . 
Q 3 D10 1 408 307 D10 D10 A . 
R 4 OCT 1 409 309 OCT D08 A . 
S 6 HEX 1 410 310 HEX D06 A . 
T 5 EIC 1 411 311 EIC EIC A . 
U 7 K   1 412 1   K   K   A . 
V 7 K   1 413 2   K   K   A . 
W 7 K   1 414 3   K   K   A . 
X 7 K   1 415 4   K   K   A . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9C09 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9C09 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9C09 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9C09 
_struct.title                        'Structure of K2P13.1 (THIK1) S136P in lipid nanodisc' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9C09 
_struct_keywords.text            'Ion channel, K2P channel, transport protein' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 3 ? 
H N N 5 ? 
I N N 4 ? 
J N N 4 ? 
K N N 6 ? 
L N N 2 ? 
M N N 3 ? 
N N N 4 ? 
O N N 4 ? 
P N N 4 ? 
Q N N 3 ? 
R N N 4 ? 
S N N 6 ? 
T N N 5 ? 
U N N 7 ? 
V N N 7 ? 
W N N 7 ? 
X N N 7 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    KCNKD_HUMAN 
_struct_ref.pdbx_db_accession          Q9HB14 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9C09 U 1 ? 350 ? Q9HB14 1 ? 350 ? 1 350 
2 1 9C09 A 1 ? 350 ? Q9HB14 1 ? 350 ? 1 350 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9C09 GLN U 59  ? UNP Q9HB14 ASN 59  'engineered mutation' 59  1 
1 9C09 GLN U 65  ? UNP Q9HB14 ASN 65  'engineered mutation' 65  2 
1 9C09 PRO U 136 ? UNP Q9HB14 SER 136 'engineered mutation' 136 3 
2 9C09 GLN A 59  ? UNP Q9HB14 ASN 59  'engineered mutation' 59  4 
2 9C09 GLN A 65  ? UNP Q9HB14 ASN 65  'engineered mutation' 65  5 
2 9C09 PRO A 136 ? UNP Q9HB14 SER 136 'engineered mutation' 136 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 14  ? GLN A 65  ? ASN U 14  GLN U 65  1 ? 52 
HELX_P HELX_P2  AA2 SER A 67  ? ARG A 83  ? SER U 67  ARG U 83  1 ? 17 
HELX_P HELX_P3  AA3 PHE A 97  ? SER A 109 ? PHE U 97  SER U 109 1 ? 13 
HELX_P HELX_P4  AA4 GLY A 122 ? GLN A 162 ? GLY U 122 GLN U 162 1 ? 41 
HELX_P HELX_P5  AA5 SER A 193 ? MET A 215 ? SER U 193 MET U 215 1 ? 23 
HELX_P HELX_P6  AA6 SER A 223 ? SER A 236 ? SER U 223 SER U 236 1 ? 14 
HELX_P HELX_P7  AA7 GLY A 255 ? MET A 294 ? GLY U 255 MET U 294 1 ? 40 
HELX_P HELX_P8  AA8 GLU B 15  ? HIS B 64  ? GLU A 15  HIS A 64  1 ? 50 
HELX_P HELX_P9  AA9 SER B 67  ? GLY B 85  ? SER A 67  GLY A 85  1 ? 19 
HELX_P HELX_P10 AB1 ASP B 96  ? SER B 109 ? ASP A 96  SER A 109 1 ? 14 
HELX_P HELX_P11 AB2 GLY B 122 ? GLN B 162 ? GLY A 122 GLN A 162 1 ? 41 
HELX_P HELX_P12 AB3 SER B 193 ? GLU B 220 ? SER A 193 GLU A 220 1 ? 28 
HELX_P HELX_P13 AB4 SER B 223 ? SER B 236 ? SER A 223 SER A 236 1 ? 14 
HELX_P HELX_P14 AB5 GLY B 255 ? MET B 294 ? GLY A 255 MET A 294 1 ? 40 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A THR 110 O ? ? ? 1_555 V K . K ? ? U THR 110 A K 413 1_555 ? ? ? ? ? ? ? 3.456 ? ? 
metalc2  metalc ? ? A THR 110 O ? ? ? 1_555 W K . K ? ? U THR 110 A K 414 1_555 ? ? ? ? ? ? ? 2.846 ? ? 
metalc3  metalc ? ? A ILE 111 O ? ? ? 1_555 V K . K ? ? U ILE 111 A K 413 1_555 ? ? ? ? ? ? ? 2.737 ? ? 
metalc4  metalc ? ? A ILE 111 O ? ? ? 1_555 X K . K ? ? U ILE 111 A K 415 1_555 ? ? ? ? ? ? ? 3.029 ? ? 
metalc5  metalc ? ? A GLY 112 O ? ? ? 1_555 U K . K ? ? U GLY 112 A K 412 1_555 ? ? ? ? ? ? ? 2.980 ? ? 
metalc6  metalc ? ? A GLY 112 O ? ? ? 1_555 X K . K ? ? U GLY 112 A K 415 1_555 ? ? ? ? ? ? ? 2.913 ? ? 
metalc7  metalc ? ? A PHE 113 O ? ? ? 1_555 U K . K ? ? U PHE 113 A K 412 1_555 ? ? ? ? ? ? ? 3.197 ? ? 
metalc8  metalc ? ? A THR 237 O ? ? ? 1_555 V K . K ? ? U THR 237 A K 413 1_555 ? ? ? ? ? ? ? 3.287 ? ? 
metalc9  metalc ? ? A THR 237 O ? ? ? 1_555 W K . K ? ? U THR 237 A K 414 1_555 ? ? ? ? ? ? ? 2.949 ? ? 
metalc10 metalc ? ? A ILE 238 O ? ? ? 1_555 V K . K ? ? U ILE 238 A K 413 1_555 ? ? ? ? ? ? ? 2.866 ? ? 
metalc11 metalc ? ? A ILE 238 O ? ? ? 1_555 X K . K ? ? U ILE 238 A K 415 1_555 ? ? ? ? ? ? ? 3.037 ? ? 
metalc12 metalc ? ? A GLY 239 O ? ? ? 1_555 U K . K ? ? U GLY 239 A K 412 1_555 ? ? ? ? ? ? ? 2.956 ? ? 
metalc13 metalc ? ? A GLY 239 O ? ? ? 1_555 X K . K ? ? U GLY 239 A K 415 1_555 ? ? ? ? ? ? ? 3.017 ? ? 
metalc14 metalc ? ? A PHE 240 O ? ? ? 1_555 U K . K ? ? U PHE 240 A K 412 1_555 ? ? ? ? ? ? ? 3.280 ? ? 
metalc15 metalc ? ? B THR 110 O ? ? ? 1_555 V K . K ? ? A THR 110 A K 413 1_555 ? ? ? ? ? ? ? 3.456 ? ? 
metalc16 metalc ? ? B THR 110 O ? ? ? 1_555 W K . K ? ? A THR 110 A K 414 1_555 ? ? ? ? ? ? ? 2.928 ? ? 
metalc17 metalc ? ? B ILE 111 O ? ? ? 1_555 V K . K ? ? A ILE 111 A K 413 1_555 ? ? ? ? ? ? ? 2.805 ? ? 
metalc18 metalc ? ? B ILE 111 O ? ? ? 1_555 X K . K ? ? A ILE 111 A K 415 1_555 ? ? ? ? ? ? ? 3.021 ? ? 
metalc19 metalc ? ? B GLY 112 O ? ? ? 1_555 U K . K ? ? A GLY 112 A K 412 1_555 ? ? ? ? ? ? ? 3.042 ? ? 
metalc20 metalc ? ? B GLY 112 O ? ? ? 1_555 X K . K ? ? A GLY 112 A K 415 1_555 ? ? ? ? ? ? ? 3.121 ? ? 
metalc21 metalc ? ? B PHE 113 O ? ? ? 1_555 U K . K ? ? A PHE 113 A K 412 1_555 ? ? ? ? ? ? ? 3.267 ? ? 
metalc22 metalc ? ? B THR 237 O ? ? ? 1_555 V K . K ? ? A THR 237 A K 413 1_555 ? ? ? ? ? ? ? 3.211 ? ? 
metalc23 metalc ? ? B THR 237 O ? ? ? 1_555 W K . K ? ? A THR 237 A K 414 1_555 ? ? ? ? ? ? ? 2.945 ? ? 
metalc24 metalc ? ? B ILE 238 O ? ? ? 1_555 V K . K ? ? A ILE 238 A K 413 1_555 ? ? ? ? ? ? ? 2.844 ? ? 
metalc25 metalc ? ? B ILE 238 O ? ? ? 1_555 X K . K ? ? A ILE 238 A K 415 1_555 ? ? ? ? ? ? ? 2.968 ? ? 
metalc26 metalc ? ? B GLY 239 O ? ? ? 1_555 U K . K ? ? A GLY 239 A K 412 1_555 ? ? ? ? ? ? ? 2.877 ? ? 
metalc27 metalc ? ? B GLY 239 O ? ? ? 1_555 X K . K ? ? A GLY 239 A K 415 1_555 ? ? ? ? ? ? ? 2.932 ? ? 
metalc28 metalc ? ? B PHE 240 O ? ? ? 1_555 U K . K ? ? A PHE 240 A K 412 1_555 ? ? ? ? ? ? ? 3.306 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O ? A THR 110 ? U THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? A ILE 111 ? U ILE 111 ? 1_555 70.3  ? 
2  O ? A THR 110 ? U THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 61.4  ? 
3  O ? A ILE 111 ? U ILE 111 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 89.6  ? 
4  O ? A THR 110 ? U THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 123.0 ? 
5  O ? A ILE 111 ? U ILE 111 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 81.4  ? 
6  O ? A THR 237 ? U THR 237 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 70.4  ? 
7  O ? A THR 110 ? U THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 93.9  ? 
8  O ? A ILE 111 ? U ILE 111 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 154.5 ? 
9  O ? A THR 237 ? U THR 237 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 65.0  ? 
10 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 91.6  ? 
11 O ? A THR 110 ? U THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 155.5 ? 
12 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 131.1 ? 
13 O ? A THR 237 ? U THR 237 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 122.2 ? 
14 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 76.9  ? 
15 O ? B THR 110 ? A THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 69.8  ? 
16 O ? A THR 110 ? U THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 65.7  ? 
17 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 123.8 ? 
18 O ? A THR 237 ? U THR 237 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 98.1  ? 
19 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 153.0 ? 
20 O ? B THR 110 ? A THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 61.5  ? 
21 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 90.2  ? 
22 O ? A THR 110 ? U THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 94.3  ? 
23 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 78.9  ? 
24 O ? A THR 237 ? U THR 237 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 155.6 ? 
25 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 127.8 ? 
26 O ? B THR 110 ? A THR 110 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 123.4 ? 
27 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 80.9  ? 
28 O ? B THR 237 ? A THR 237 ? 1_555 K ? V K . ? A K 413 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 71.7  ? 
29 O ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 414 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 72.9  ? 
30 O ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 414 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 122.0 ? 
31 O ? A THR 237 ? U THR 237 ? 1_555 K ? W K . ? A K 414 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 76.3  ? 
32 O ? A THR 110 ? U THR 110 ? 1_555 K ? W K . ? A K 414 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 77.4  ? 
33 O ? A THR 237 ? U THR 237 ? 1_555 K ? W K . ? A K 414 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 112.8 ? 
34 O ? B THR 110 ? A THR 110 ? 1_555 K ? W K . ? A K 414 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 71.2  ? 
35 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? A GLY 112 ? U GLY 112 ? 1_555 70.7  ? 
36 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 74.1  ? 
37 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 131.7 ? 
38 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 86.8  ? 
39 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 76.2  ? 
40 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 69.7  ? 
41 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 113.0 ? 
42 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 154.2 ? 
43 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 71.2  ? 
44 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 128.5 ? 
45 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 151.5 ? 
46 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 119.5 ? 
47 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 80.9  ? 
48 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 71.6  ? 
49 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 70.3  ? 
50 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 72.5  ? 
51 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 82.0  ? 
52 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 117.3 ? 
53 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 154.0 ? 
54 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 75.4  ? 
55 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 132.9 ? 
56 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 129.4 ? 
57 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 72.4  ? 
58 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 154.3 ? 
59 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 116.3 ? 
60 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 87.9  ? 
61 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 78.0  ? 
62 O ? B ILE 238 ? A ILE 238 ? 1_555 K ? X K . ? A K 415 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 69.2  ? 
63 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? A PHE 113 ? U PHE 113 ? 1_555 65.6  ? 
64 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 76.2  ? 
65 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 80.8  ? 
66 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 127.0 ? 
67 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 75.6  ? 
68 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 62.8  ? 
69 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 119.9 ? 
70 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 150.7 ? 
71 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 73.5  ? 
72 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 80.1  ? 
73 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 153.2 ? 
74 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 126.1 ? 
75 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 126.7 ? 
76 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 79.4  ? 
77 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 63.6  ? 
78 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 72.2  ? 
79 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 126.1 ? 
80 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 120.1 ? 
81 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 157.9 ? 
82 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 80.2  ? 
83 O ? B PHE 113 ? A PHE 113 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 83.0  ? 
84 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 85.9  ? 
85 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 80.3  ? 
86 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 158.1 ? 
87 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 122.3 ? 
88 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 127.3 ? 
89 O ? B PHE 113 ? A PHE 113 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 74.1  ? 
90 O ? B GLY 239 ? A GLY 239 ? 1_555 K ? U K . ? A K 412 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 64.3  ? 
# 
_pdbx_entry_details.entry_id                   9C09 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLN U 65  ? ? 55.78   18.68   
2  1 ASP U 96  ? ? -82.81  -74.27  
3  1 PHE U 97  ? ? -144.16 -25.98  
4  1 TYR U 216 ? ? 81.56   -17.39  
5  1 ASN U 248 ? ? -143.39 31.05   
6  1 ALA U 249 ? ? 58.60   -114.26 
7  1 GLU U 252 ? ? 51.86   -114.98 
8  1 GLN U 254 ? ? 68.68   -6.81   
9  1 TRP A 95  ? ? 53.95   16.44   
10 1 ALA A 249 ? ? 56.84   -117.95 
11 1 GLU A 252 ? ? 45.83   -123.66 
12 1 GLN A 254 ? ? 68.84   -5.62   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9C09 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9C09 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.36 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               446461 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.8 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'Homodimer of human K2P13.1 (THIK1) with S136P activating mutation' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9C09 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9C09 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            'FEI VITROBOT MARK IV' 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9C09 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 U MET 1   ? A MET 1   
2   1 Y 1 U ALA 2   ? A ALA 2   
3   1 Y 1 U GLY 3   ? A GLY 3   
4   1 Y 1 U ARG 4   ? A ARG 4   
5   1 Y 1 U GLY 5   ? A GLY 5   
6   1 Y 1 U PHE 6   ? A PHE 6   
7   1 Y 1 U SER 7   ? A SER 7   
8   1 Y 1 U TRP 8   ? A TRP 8   
9   1 Y 1 U GLY 9   ? A GLY 9   
10  1 Y 1 U PRO 10  ? A PRO 10  
11  1 Y 1 U GLY 11  ? A GLY 11  
12  1 Y 1 U HIS 12  ? A HIS 12  
13  1 Y 1 U LEU 13  ? A LEU 13  
14  1 Y 1 U ARG 163 ? A ARG 163 
15  1 Y 1 U GLN 164 ? A GLN 164 
16  1 Y 1 U LEU 165 ? A LEU 165 
17  1 Y 1 U ARG 166 ? A ARG 166 
18  1 Y 1 U ARG 167 ? A ARG 167 
19  1 Y 1 U ARG 168 ? A ARG 168 
20  1 Y 1 U GLY 169 ? A GLY 169 
21  1 Y 1 U ALA 170 ? A ALA 170 
22  1 Y 1 U LEU 171 ? A LEU 171 
23  1 Y 1 U PRO 172 ? A PRO 172 
24  1 Y 1 U GLN 173 ? A GLN 173 
25  1 Y 1 U GLU 174 ? A GLU 174 
26  1 Y 1 U SER 175 ? A SER 175 
27  1 Y 1 U LEU 176 ? A LEU 176 
28  1 Y 1 U LYS 177 ? A LYS 177 
29  1 Y 1 U ASP 178 ? A ASP 178 
30  1 Y 1 U ALA 179 ? A ALA 179 
31  1 Y 1 U GLY 180 ? A GLY 180 
32  1 Y 1 U GLN 181 ? A GLN 181 
33  1 Y 1 U CYS 182 ? A CYS 182 
34  1 Y 1 U GLU 183 ? A GLU 183 
35  1 Y 1 U VAL 184 ? A VAL 184 
36  1 Y 1 U ASP 185 ? A ASP 185 
37  1 Y 1 U SER 186 ? A SER 186 
38  1 Y 1 U LEU 187 ? A LEU 187 
39  1 Y 1 U SER 296 ? A SER 296 
40  1 Y 1 U GLY 297 ? A GLY 297 
41  1 Y 1 U CYS 298 ? A CYS 298 
42  1 Y 1 U CYS 299 ? A CYS 299 
43  1 Y 1 U PRO 300 ? A PRO 300 
44  1 Y 1 U GLN 301 ? A GLN 301 
45  1 Y 1 U CYS 302 ? A CYS 302 
46  1 Y 1 U GLN 303 ? A GLN 303 
47  1 Y 1 U ARG 304 ? A ARG 304 
48  1 Y 1 U GLY 305 ? A GLY 305 
49  1 Y 1 U LEU 306 ? A LEU 306 
50  1 Y 1 U LEU 307 ? A LEU 307 
51  1 Y 1 U ARG 308 ? A ARG 308 
52  1 Y 1 U SER 309 ? A SER 309 
53  1 Y 1 U ARG 310 ? A ARG 310 
54  1 Y 1 U ARG 311 ? A ARG 311 
55  1 Y 1 U ASN 312 ? A ASN 312 
56  1 Y 1 U VAL 313 ? A VAL 313 
57  1 Y 1 U VAL 314 ? A VAL 314 
58  1 Y 1 U MET 315 ? A MET 315 
59  1 Y 1 U PRO 316 ? A PRO 316 
60  1 Y 1 U GLY 317 ? A GLY 317 
61  1 Y 1 U SER 318 ? A SER 318 
62  1 Y 1 U VAL 319 ? A VAL 319 
63  1 Y 1 U ARG 320 ? A ARG 320 
64  1 Y 1 U ASN 321 ? A ASN 321 
65  1 Y 1 U ARG 322 ? A ARG 322 
66  1 Y 1 U CYS 323 ? A CYS 323 
67  1 Y 1 U ASN 324 ? A ASN 324 
68  1 Y 1 U ILE 325 ? A ILE 325 
69  1 Y 1 U SER 326 ? A SER 326 
70  1 Y 1 U ILE 327 ? A ILE 327 
71  1 Y 1 U GLU 328 ? A GLU 328 
72  1 Y 1 U THR 329 ? A THR 329 
73  1 Y 1 U ASP 330 ? A ASP 330 
74  1 Y 1 U GLY 331 ? A GLY 331 
75  1 Y 1 U VAL 332 ? A VAL 332 
76  1 Y 1 U ALA 333 ? A ALA 333 
77  1 Y 1 U GLU 334 ? A GLU 334 
78  1 Y 1 U SER 335 ? A SER 335 
79  1 Y 1 U ASP 336 ? A ASP 336 
80  1 Y 1 U THR 337 ? A THR 337 
81  1 Y 1 U ASP 338 ? A ASP 338 
82  1 Y 1 U GLY 339 ? A GLY 339 
83  1 Y 1 U ARG 340 ? A ARG 340 
84  1 Y 1 U ARG 341 ? A ARG 341 
85  1 Y 1 U LEU 342 ? A LEU 342 
86  1 Y 1 U SER 343 ? A SER 343 
87  1 Y 1 U GLY 344 ? A GLY 344 
88  1 Y 1 U GLU 345 ? A GLU 345 
89  1 Y 1 U MET 346 ? A MET 346 
90  1 Y 1 U ILE 347 ? A ILE 347 
91  1 Y 1 U SER 348 ? A SER 348 
92  1 Y 1 U MET 349 ? A MET 349 
93  1 Y 1 U LYS 350 ? A LYS 350 
94  1 Y 1 A MET 1   ? B MET 1   
95  1 Y 1 A ALA 2   ? B ALA 2   
96  1 Y 1 A GLY 3   ? B GLY 3   
97  1 Y 1 A ARG 4   ? B ARG 4   
98  1 Y 1 A GLY 5   ? B GLY 5   
99  1 Y 1 A PHE 6   ? B PHE 6   
100 1 Y 1 A SER 7   ? B SER 7   
101 1 Y 1 A TRP 8   ? B TRP 8   
102 1 Y 1 A GLY 9   ? B GLY 9   
103 1 Y 1 A PRO 10  ? B PRO 10  
104 1 Y 1 A GLY 11  ? B GLY 11  
105 1 Y 1 A HIS 12  ? B HIS 12  
106 1 Y 1 A LEU 13  ? B LEU 13  
107 1 Y 1 A ARG 163 ? B ARG 163 
108 1 Y 1 A GLN 164 ? B GLN 164 
109 1 Y 1 A LEU 165 ? B LEU 165 
110 1 Y 1 A ARG 166 ? B ARG 166 
111 1 Y 1 A ARG 167 ? B ARG 167 
112 1 Y 1 A ARG 168 ? B ARG 168 
113 1 Y 1 A GLY 169 ? B GLY 169 
114 1 Y 1 A ALA 170 ? B ALA 170 
115 1 Y 1 A LEU 171 ? B LEU 171 
116 1 Y 1 A PRO 172 ? B PRO 172 
117 1 Y 1 A GLN 173 ? B GLN 173 
118 1 Y 1 A GLU 174 ? B GLU 174 
119 1 Y 1 A SER 175 ? B SER 175 
120 1 Y 1 A LEU 176 ? B LEU 176 
121 1 Y 1 A LYS 177 ? B LYS 177 
122 1 Y 1 A ASP 178 ? B ASP 178 
123 1 Y 1 A ALA 179 ? B ALA 179 
124 1 Y 1 A GLY 180 ? B GLY 180 
125 1 Y 1 A GLN 181 ? B GLN 181 
126 1 Y 1 A CYS 182 ? B CYS 182 
127 1 Y 1 A GLU 183 ? B GLU 183 
128 1 Y 1 A VAL 184 ? B VAL 184 
129 1 Y 1 A ASP 185 ? B ASP 185 
130 1 Y 1 A SER 186 ? B SER 186 
131 1 Y 1 A LEU 187 ? B LEU 187 
132 1 Y 1 A SER 296 ? B SER 296 
133 1 Y 1 A GLY 297 ? B GLY 297 
134 1 Y 1 A CYS 298 ? B CYS 298 
135 1 Y 1 A CYS 299 ? B CYS 299 
136 1 Y 1 A PRO 300 ? B PRO 300 
137 1 Y 1 A GLN 301 ? B GLN 301 
138 1 Y 1 A CYS 302 ? B CYS 302 
139 1 Y 1 A GLN 303 ? B GLN 303 
140 1 Y 1 A ARG 304 ? B ARG 304 
141 1 Y 1 A GLY 305 ? B GLY 305 
142 1 Y 1 A LEU 306 ? B LEU 306 
143 1 Y 1 A LEU 307 ? B LEU 307 
144 1 Y 1 A ARG 308 ? B ARG 308 
145 1 Y 1 A SER 309 ? B SER 309 
146 1 Y 1 A ARG 310 ? B ARG 310 
147 1 Y 1 A ARG 311 ? B ARG 311 
148 1 Y 1 A ASN 312 ? B ASN 312 
149 1 Y 1 A VAL 313 ? B VAL 313 
150 1 Y 1 A VAL 314 ? B VAL 314 
151 1 Y 1 A MET 315 ? B MET 315 
152 1 Y 1 A PRO 316 ? B PRO 316 
153 1 Y 1 A GLY 317 ? B GLY 317 
154 1 Y 1 A SER 318 ? B SER 318 
155 1 Y 1 A VAL 319 ? B VAL 319 
156 1 Y 1 A ARG 320 ? B ARG 320 
157 1 Y 1 A ASN 321 ? B ASN 321 
158 1 Y 1 A ARG 322 ? B ARG 322 
159 1 Y 1 A CYS 323 ? B CYS 323 
160 1 Y 1 A ASN 324 ? B ASN 324 
161 1 Y 1 A ILE 325 ? B ILE 325 
162 1 Y 1 A SER 326 ? B SER 326 
163 1 Y 1 A ILE 327 ? B ILE 327 
164 1 Y 1 A GLU 328 ? B GLU 328 
165 1 Y 1 A THR 329 ? B THR 329 
166 1 Y 1 A ASP 330 ? B ASP 330 
167 1 Y 1 A GLY 331 ? B GLY 331 
168 1 Y 1 A VAL 332 ? B VAL 332 
169 1 Y 1 A ALA 333 ? B ALA 333 
170 1 Y 1 A GLU 334 ? B GLU 334 
171 1 Y 1 A SER 335 ? B SER 335 
172 1 Y 1 A ASP 336 ? B ASP 336 
173 1 Y 1 A THR 337 ? B THR 337 
174 1 Y 1 A ASP 338 ? B ASP 338 
175 1 Y 1 A GLY 339 ? B GLY 339 
176 1 Y 1 A ARG 340 ? B ARG 340 
177 1 Y 1 A ARG 341 ? B ARG 341 
178 1 Y 1 A LEU 342 ? B LEU 342 
179 1 Y 1 A SER 343 ? B SER 343 
180 1 Y 1 A GLY 344 ? B GLY 344 
181 1 Y 1 A GLU 345 ? B GLU 345 
182 1 Y 1 A MET 346 ? B MET 346 
183 1 Y 1 A ILE 347 ? B ILE 347 
184 1 Y 1 A SER 348 ? B SER 348 
185 1 Y 1 A MET 349 ? B MET 349 
186 1 Y 1 A LYS 350 ? B LYS 350 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
D10 C1   C N N 88  
D10 C2   C N N 89  
D10 C3   C N N 90  
D10 C4   C N N 91  
D10 C5   C N N 92  
D10 C6   C N N 93  
D10 C7   C N N 94  
D10 C8   C N N 95  
D10 C9   C N N 96  
D10 C10  C N N 97  
D10 H11  H N N 98  
D10 H12  H N N 99  
D10 H13  H N N 100 
D10 H21  H N N 101 
D10 H22  H N N 102 
D10 H31  H N N 103 
D10 H32  H N N 104 
D10 H41  H N N 105 
D10 H42  H N N 106 
D10 H51  H N N 107 
D10 H52  H N N 108 
D10 H61  H N N 109 
D10 H62  H N N 110 
D10 H71  H N N 111 
D10 H72  H N N 112 
D10 H81  H N N 113 
D10 H82  H N N 114 
D10 H91  H N N 115 
D10 H92  H N N 116 
D10 H101 H N N 117 
D10 H102 H N N 118 
D10 H103 H N N 119 
D12 C1   C N N 120 
D12 C2   C N N 121 
D12 C3   C N N 122 
D12 C4   C N N 123 
D12 C5   C N N 124 
D12 C6   C N N 125 
D12 C7   C N N 126 
D12 C8   C N N 127 
D12 C9   C N N 128 
D12 C10  C N N 129 
D12 C11  C N N 130 
D12 C12  C N N 131 
D12 H11  H N N 132 
D12 H12  H N N 133 
D12 H13  H N N 134 
D12 H21  H N N 135 
D12 H22  H N N 136 
D12 H31  H N N 137 
D12 H32  H N N 138 
D12 H41  H N N 139 
D12 H42  H N N 140 
D12 H51  H N N 141 
D12 H52  H N N 142 
D12 H61  H N N 143 
D12 H62  H N N 144 
D12 H71  H N N 145 
D12 H72  H N N 146 
D12 H81  H N N 147 
D12 H82  H N N 148 
D12 H91  H N N 149 
D12 H92  H N N 150 
D12 H101 H N N 151 
D12 H102 H N N 152 
D12 H111 H N N 153 
D12 H112 H N N 154 
D12 H121 H N N 155 
D12 H122 H N N 156 
D12 H123 H N N 157 
EIC C1   C N N 158 
EIC C2   C N N 159 
EIC C3   C N N 160 
EIC C4   C N N 161 
EIC C5   C N N 162 
EIC C6   C N N 163 
EIC C7   C N N 164 
EIC C8   C N N 165 
EIC C9   C N N 166 
EIC C10  C N N 167 
EIC C11  C N N 168 
EIC C12  C N N 169 
EIC C13  C N N 170 
EIC C14  C N N 171 
EIC C15  C N N 172 
EIC C16  C N N 173 
EIC C17  C N N 174 
EIC C18  C N N 175 
EIC O1   O N N 176 
EIC O2   O N N 177 
EIC H21  H N N 178 
EIC H22  H N N 179 
EIC H31  H N N 180 
EIC H32  H N N 181 
EIC H41  H N N 182 
EIC H42  H N N 183 
EIC H51  H N N 184 
EIC H52  H N N 185 
EIC H61  H N N 186 
EIC H62  H N N 187 
EIC H71  H N N 188 
EIC H72  H N N 189 
EIC H81  H N N 190 
EIC H82  H N N 191 
EIC H91  H N N 192 
EIC H1O1 H N N 193 
EIC H111 H N N 194 
EIC H112 H N N 195 
EIC H121 H N N 196 
EIC H131 H N N 197 
EIC H141 H N N 198 
EIC H142 H N N 199 
EIC H151 H N N 200 
EIC H152 H N N 201 
EIC H161 H N N 202 
EIC H162 H N N 203 
EIC H171 H N N 204 
EIC H172 H N N 205 
EIC H181 H N N 206 
EIC H182 H N N 207 
EIC H183 H N N 208 
EIC HO2  H N N 209 
GLN N    N N N 210 
GLN CA   C N S 211 
GLN C    C N N 212 
GLN O    O N N 213 
GLN CB   C N N 214 
GLN CG   C N N 215 
GLN CD   C N N 216 
GLN OE1  O N N 217 
GLN NE2  N N N 218 
GLN OXT  O N N 219 
GLN H    H N N 220 
GLN H2   H N N 221 
GLN HA   H N N 222 
GLN HB2  H N N 223 
GLN HB3  H N N 224 
GLN HG2  H N N 225 
GLN HG3  H N N 226 
GLN HE21 H N N 227 
GLN HE22 H N N 228 
GLN HXT  H N N 229 
GLU N    N N N 230 
GLU CA   C N S 231 
GLU C    C N N 232 
GLU O    O N N 233 
GLU CB   C N N 234 
GLU CG   C N N 235 
GLU CD   C N N 236 
GLU OE1  O N N 237 
GLU OE2  O N N 238 
GLU OXT  O N N 239 
GLU H    H N N 240 
GLU H2   H N N 241 
GLU HA   H N N 242 
GLU HB2  H N N 243 
GLU HB3  H N N 244 
GLU HG2  H N N 245 
GLU HG3  H N N 246 
GLU HE2  H N N 247 
GLU HXT  H N N 248 
GLY N    N N N 249 
GLY CA   C N N 250 
GLY C    C N N 251 
GLY O    O N N 252 
GLY OXT  O N N 253 
GLY H    H N N 254 
GLY H2   H N N 255 
GLY HA2  H N N 256 
GLY HA3  H N N 257 
GLY HXT  H N N 258 
HEX C1   C N N 259 
HEX C2   C N N 260 
HEX C3   C N N 261 
HEX C4   C N N 262 
HEX C5   C N N 263 
HEX C6   C N N 264 
HEX H11  H N N 265 
HEX H12  H N N 266 
HEX H13  H N N 267 
HEX H21  H N N 268 
HEX H22  H N N 269 
HEX H31  H N N 270 
HEX H32  H N N 271 
HEX H41  H N N 272 
HEX H42  H N N 273 
HEX H51  H N N 274 
HEX H52  H N N 275 
HEX H61  H N N 276 
HEX H62  H N N 277 
HEX H63  H N N 278 
HIS N    N N N 279 
HIS CA   C N S 280 
HIS C    C N N 281 
HIS O    O N N 282 
HIS CB   C N N 283 
HIS CG   C Y N 284 
HIS ND1  N Y N 285 
HIS CD2  C Y N 286 
HIS CE1  C Y N 287 
HIS NE2  N Y N 288 
HIS OXT  O N N 289 
HIS H    H N N 290 
HIS H2   H N N 291 
HIS HA   H N N 292 
HIS HB2  H N N 293 
HIS HB3  H N N 294 
HIS HD1  H N N 295 
HIS HD2  H N N 296 
HIS HE1  H N N 297 
HIS HE2  H N N 298 
HIS HXT  H N N 299 
ILE N    N N N 300 
ILE CA   C N S 301 
ILE C    C N N 302 
ILE O    O N N 303 
ILE CB   C N S 304 
ILE CG1  C N N 305 
ILE CG2  C N N 306 
ILE CD1  C N N 307 
ILE OXT  O N N 308 
ILE H    H N N 309 
ILE H2   H N N 310 
ILE HA   H N N 311 
ILE HB   H N N 312 
ILE HG12 H N N 313 
ILE HG13 H N N 314 
ILE HG21 H N N 315 
ILE HG22 H N N 316 
ILE HG23 H N N 317 
ILE HD11 H N N 318 
ILE HD12 H N N 319 
ILE HD13 H N N 320 
ILE HXT  H N N 321 
K   K    K N N 322 
LEU N    N N N 323 
LEU CA   C N S 324 
LEU C    C N N 325 
LEU O    O N N 326 
LEU CB   C N N 327 
LEU CG   C N N 328 
LEU CD1  C N N 329 
LEU CD2  C N N 330 
LEU OXT  O N N 331 
LEU H    H N N 332 
LEU H2   H N N 333 
LEU HA   H N N 334 
LEU HB2  H N N 335 
LEU HB3  H N N 336 
LEU HG   H N N 337 
LEU HD11 H N N 338 
LEU HD12 H N N 339 
LEU HD13 H N N 340 
LEU HD21 H N N 341 
LEU HD22 H N N 342 
LEU HD23 H N N 343 
LEU HXT  H N N 344 
LYS N    N N N 345 
LYS CA   C N S 346 
LYS C    C N N 347 
LYS O    O N N 348 
LYS CB   C N N 349 
LYS CG   C N N 350 
LYS CD   C N N 351 
LYS CE   C N N 352 
LYS NZ   N N N 353 
LYS OXT  O N N 354 
LYS H    H N N 355 
LYS H2   H N N 356 
LYS HA   H N N 357 
LYS HB2  H N N 358 
LYS HB3  H N N 359 
LYS HG2  H N N 360 
LYS HG3  H N N 361 
LYS HD2  H N N 362 
LYS HD3  H N N 363 
LYS HE2  H N N 364 
LYS HE3  H N N 365 
LYS HZ1  H N N 366 
LYS HZ2  H N N 367 
LYS HZ3  H N N 368 
LYS HXT  H N N 369 
MET N    N N N 370 
MET CA   C N S 371 
MET C    C N N 372 
MET O    O N N 373 
MET CB   C N N 374 
MET CG   C N N 375 
MET SD   S N N 376 
MET CE   C N N 377 
MET OXT  O N N 378 
MET H    H N N 379 
MET H2   H N N 380 
MET HA   H N N 381 
MET HB2  H N N 382 
MET HB3  H N N 383 
MET HG2  H N N 384 
MET HG3  H N N 385 
MET HE1  H N N 386 
MET HE2  H N N 387 
MET HE3  H N N 388 
MET HXT  H N N 389 
OCT C1   C N N 390 
OCT C2   C N N 391 
OCT C3   C N N 392 
OCT C4   C N N 393 
OCT C5   C N N 394 
OCT C6   C N N 395 
OCT C7   C N N 396 
OCT C8   C N N 397 
OCT H11  H N N 398 
OCT H12  H N N 399 
OCT H13  H N N 400 
OCT H21  H N N 401 
OCT H22  H N N 402 
OCT H31  H N N 403 
OCT H32  H N N 404 
OCT H41  H N N 405 
OCT H42  H N N 406 
OCT H51  H N N 407 
OCT H52  H N N 408 
OCT H61  H N N 409 
OCT H62  H N N 410 
OCT H71  H N N 411 
OCT H72  H N N 412 
OCT H81  H N N 413 
OCT H82  H N N 414 
OCT H83  H N N 415 
PHE N    N N N 416 
PHE CA   C N S 417 
PHE C    C N N 418 
PHE O    O N N 419 
PHE CB   C N N 420 
PHE CG   C Y N 421 
PHE CD1  C Y N 422 
PHE CD2  C Y N 423 
PHE CE1  C Y N 424 
PHE CE2  C Y N 425 
PHE CZ   C Y N 426 
PHE OXT  O N N 427 
PHE H    H N N 428 
PHE H2   H N N 429 
PHE HA   H N N 430 
PHE HB2  H N N 431 
PHE HB3  H N N 432 
PHE HD1  H N N 433 
PHE HD2  H N N 434 
PHE HE1  H N N 435 
PHE HE2  H N N 436 
PHE HZ   H N N 437 
PHE HXT  H N N 438 
PRO N    N N N 439 
PRO CA   C N S 440 
PRO C    C N N 441 
PRO O    O N N 442 
PRO CB   C N N 443 
PRO CG   C N N 444 
PRO CD   C N N 445 
PRO OXT  O N N 446 
PRO H    H N N 447 
PRO HA   H N N 448 
PRO HB2  H N N 449 
PRO HB3  H N N 450 
PRO HG2  H N N 451 
PRO HG3  H N N 452 
PRO HD2  H N N 453 
PRO HD3  H N N 454 
PRO HXT  H N N 455 
SER N    N N N 456 
SER CA   C N S 457 
SER C    C N N 458 
SER O    O N N 459 
SER CB   C N N 460 
SER OG   O N N 461 
SER OXT  O N N 462 
SER H    H N N 463 
SER H2   H N N 464 
SER HA   H N N 465 
SER HB2  H N N 466 
SER HB3  H N N 467 
SER HG   H N N 468 
SER HXT  H N N 469 
THR N    N N N 470 
THR CA   C N S 471 
THR C    C N N 472 
THR O    O N N 473 
THR CB   C N R 474 
THR OG1  O N N 475 
THR CG2  C N N 476 
THR OXT  O N N 477 
THR H    H N N 478 
THR H2   H N N 479 
THR HA   H N N 480 
THR HB   H N N 481 
THR HG1  H N N 482 
THR HG21 H N N 483 
THR HG22 H N N 484 
THR HG23 H N N 485 
THR HXT  H N N 486 
TRP N    N N N 487 
TRP CA   C N S 488 
TRP C    C N N 489 
TRP O    O N N 490 
TRP CB   C N N 491 
TRP CG   C Y N 492 
TRP CD1  C Y N 493 
TRP CD2  C Y N 494 
TRP NE1  N Y N 495 
TRP CE2  C Y N 496 
TRP CE3  C Y N 497 
TRP CZ2  C Y N 498 
TRP CZ3  C Y N 499 
TRP CH2  C Y N 500 
TRP OXT  O N N 501 
TRP H    H N N 502 
TRP H2   H N N 503 
TRP HA   H N N 504 
TRP HB2  H N N 505 
TRP HB3  H N N 506 
TRP HD1  H N N 507 
TRP HE1  H N N 508 
TRP HE3  H N N 509 
TRP HZ2  H N N 510 
TRP HZ3  H N N 511 
TRP HH2  H N N 512 
TRP HXT  H N N 513 
TYR N    N N N 514 
TYR CA   C N S 515 
TYR C    C N N 516 
TYR O    O N N 517 
TYR CB   C N N 518 
TYR CG   C Y N 519 
TYR CD1  C Y N 520 
TYR CD2  C Y N 521 
TYR CE1  C Y N 522 
TYR CE2  C Y N 523 
TYR CZ   C Y N 524 
TYR OH   O N N 525 
TYR OXT  O N N 526 
TYR H    H N N 527 
TYR H2   H N N 528 
TYR HA   H N N 529 
TYR HB2  H N N 530 
TYR HB3  H N N 531 
TYR HD1  H N N 532 
TYR HD2  H N N 533 
TYR HE1  H N N 534 
TYR HE2  H N N 535 
TYR HH   H N N 536 
TYR HXT  H N N 537 
VAL N    N N N 538 
VAL CA   C N S 539 
VAL C    C N N 540 
VAL O    O N N 541 
VAL CB   C N N 542 
VAL CG1  C N N 543 
VAL CG2  C N N 544 
VAL OXT  O N N 545 
VAL H    H N N 546 
VAL H2   H N N 547 
VAL HA   H N N 548 
VAL HB   H N N 549 
VAL HG11 H N N 550 
VAL HG12 H N N 551 
VAL HG13 H N N 552 
VAL HG21 H N N 553 
VAL HG22 H N N 554 
VAL HG23 H N N 555 
VAL HXT  H N N 556 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
D10 C1  C2   sing N N 83  
D10 C1  H11  sing N N 84  
D10 C1  H12  sing N N 85  
D10 C1  H13  sing N N 86  
D10 C2  C3   sing N N 87  
D10 C2  H21  sing N N 88  
D10 C2  H22  sing N N 89  
D10 C3  C4   sing N N 90  
D10 C3  H31  sing N N 91  
D10 C3  H32  sing N N 92  
D10 C4  C5   sing N N 93  
D10 C4  H41  sing N N 94  
D10 C4  H42  sing N N 95  
D10 C5  C6   sing N N 96  
D10 C5  H51  sing N N 97  
D10 C5  H52  sing N N 98  
D10 C6  C7   sing N N 99  
D10 C6  H61  sing N N 100 
D10 C6  H62  sing N N 101 
D10 C7  C8   sing N N 102 
D10 C7  H71  sing N N 103 
D10 C7  H72  sing N N 104 
D10 C8  C9   sing N N 105 
D10 C8  H81  sing N N 106 
D10 C8  H82  sing N N 107 
D10 C9  C10  sing N N 108 
D10 C9  H91  sing N N 109 
D10 C9  H92  sing N N 110 
D10 C10 H101 sing N N 111 
D10 C10 H102 sing N N 112 
D10 C10 H103 sing N N 113 
D12 C1  C2   sing N N 114 
D12 C1  H11  sing N N 115 
D12 C1  H12  sing N N 116 
D12 C1  H13  sing N N 117 
D12 C2  C3   sing N N 118 
D12 C2  H21  sing N N 119 
D12 C2  H22  sing N N 120 
D12 C3  C4   sing N N 121 
D12 C3  H31  sing N N 122 
D12 C3  H32  sing N N 123 
D12 C4  C5   sing N N 124 
D12 C4  H41  sing N N 125 
D12 C4  H42  sing N N 126 
D12 C5  C6   sing N N 127 
D12 C5  H51  sing N N 128 
D12 C5  H52  sing N N 129 
D12 C6  C7   sing N N 130 
D12 C6  H61  sing N N 131 
D12 C6  H62  sing N N 132 
D12 C7  C8   sing N N 133 
D12 C7  H71  sing N N 134 
D12 C7  H72  sing N N 135 
D12 C8  C9   sing N N 136 
D12 C8  H81  sing N N 137 
D12 C8  H82  sing N N 138 
D12 C9  C10  sing N N 139 
D12 C9  H91  sing N N 140 
D12 C9  H92  sing N N 141 
D12 C10 C11  sing N N 142 
D12 C10 H101 sing N N 143 
D12 C10 H102 sing N N 144 
D12 C11 C12  sing N N 145 
D12 C11 H111 sing N N 146 
D12 C11 H112 sing N N 147 
D12 C12 H121 sing N N 148 
D12 C12 H122 sing N N 149 
D12 C12 H123 sing N N 150 
EIC C1  C2   sing N N 151 
EIC C1  O1   doub N N 152 
EIC C1  O2   sing N N 153 
EIC C2  C3   sing N N 154 
EIC C2  H21  sing N N 155 
EIC C2  H22  sing N N 156 
EIC C3  C4   sing N N 157 
EIC C3  H31  sing N N 158 
EIC C3  H32  sing N N 159 
EIC C4  C5   sing N N 160 
EIC C4  H41  sing N N 161 
EIC C4  H42  sing N N 162 
EIC C5  C6   sing N N 163 
EIC C5  H51  sing N N 164 
EIC C5  H52  sing N N 165 
EIC C6  C7   sing N N 166 
EIC C6  H61  sing N N 167 
EIC C6  H62  sing N N 168 
EIC C7  C8   sing N N 169 
EIC C7  H71  sing N N 170 
EIC C7  H72  sing N N 171 
EIC C8  C9   sing N N 172 
EIC C8  H81  sing N N 173 
EIC C8  H82  sing N N 174 
EIC C9  C10  doub N Z 175 
EIC C9  H91  sing N N 176 
EIC C10 C11  sing N N 177 
EIC C10 H1O1 sing N N 178 
EIC C11 C12  sing N N 179 
EIC C11 H111 sing N N 180 
EIC C11 H112 sing N N 181 
EIC C12 C13  doub N Z 182 
EIC C12 H121 sing N N 183 
EIC C13 C14  sing N N 184 
EIC C13 H131 sing N N 185 
EIC C14 C15  sing N N 186 
EIC C14 H141 sing N N 187 
EIC C14 H142 sing N N 188 
EIC C15 C16  sing N N 189 
EIC C15 H151 sing N N 190 
EIC C15 H152 sing N N 191 
EIC C16 C17  sing N N 192 
EIC C16 H161 sing N N 193 
EIC C16 H162 sing N N 194 
EIC C17 C18  sing N N 195 
EIC C17 H171 sing N N 196 
EIC C17 H172 sing N N 197 
EIC C18 H181 sing N N 198 
EIC C18 H182 sing N N 199 
EIC C18 H183 sing N N 200 
EIC O2  HO2  sing N N 201 
GLN N   CA   sing N N 202 
GLN N   H    sing N N 203 
GLN N   H2   sing N N 204 
GLN CA  C    sing N N 205 
GLN CA  CB   sing N N 206 
GLN CA  HA   sing N N 207 
GLN C   O    doub N N 208 
GLN C   OXT  sing N N 209 
GLN CB  CG   sing N N 210 
GLN CB  HB2  sing N N 211 
GLN CB  HB3  sing N N 212 
GLN CG  CD   sing N N 213 
GLN CG  HG2  sing N N 214 
GLN CG  HG3  sing N N 215 
GLN CD  OE1  doub N N 216 
GLN CD  NE2  sing N N 217 
GLN NE2 HE21 sing N N 218 
GLN NE2 HE22 sing N N 219 
GLN OXT HXT  sing N N 220 
GLU N   CA   sing N N 221 
GLU N   H    sing N N 222 
GLU N   H2   sing N N 223 
GLU CA  C    sing N N 224 
GLU CA  CB   sing N N 225 
GLU CA  HA   sing N N 226 
GLU C   O    doub N N 227 
GLU C   OXT  sing N N 228 
GLU CB  CG   sing N N 229 
GLU CB  HB2  sing N N 230 
GLU CB  HB3  sing N N 231 
GLU CG  CD   sing N N 232 
GLU CG  HG2  sing N N 233 
GLU CG  HG3  sing N N 234 
GLU CD  OE1  doub N N 235 
GLU CD  OE2  sing N N 236 
GLU OE2 HE2  sing N N 237 
GLU OXT HXT  sing N N 238 
GLY N   CA   sing N N 239 
GLY N   H    sing N N 240 
GLY N   H2   sing N N 241 
GLY CA  C    sing N N 242 
GLY CA  HA2  sing N N 243 
GLY CA  HA3  sing N N 244 
GLY C   O    doub N N 245 
GLY C   OXT  sing N N 246 
GLY OXT HXT  sing N N 247 
HEX C1  C2   sing N N 248 
HEX C1  H11  sing N N 249 
HEX C1  H12  sing N N 250 
HEX C1  H13  sing N N 251 
HEX C2  C3   sing N N 252 
HEX C2  H21  sing N N 253 
HEX C2  H22  sing N N 254 
HEX C3  C4   sing N N 255 
HEX C3  H31  sing N N 256 
HEX C3  H32  sing N N 257 
HEX C4  C5   sing N N 258 
HEX C4  H41  sing N N 259 
HEX C4  H42  sing N N 260 
HEX C5  C6   sing N N 261 
HEX C5  H51  sing N N 262 
HEX C5  H52  sing N N 263 
HEX C6  H61  sing N N 264 
HEX C6  H62  sing N N 265 
HEX C6  H63  sing N N 266 
HIS N   CA   sing N N 267 
HIS N   H    sing N N 268 
HIS N   H2   sing N N 269 
HIS CA  C    sing N N 270 
HIS CA  CB   sing N N 271 
HIS CA  HA   sing N N 272 
HIS C   O    doub N N 273 
HIS C   OXT  sing N N 274 
HIS CB  CG   sing N N 275 
HIS CB  HB2  sing N N 276 
HIS CB  HB3  sing N N 277 
HIS CG  ND1  sing Y N 278 
HIS CG  CD2  doub Y N 279 
HIS ND1 CE1  doub Y N 280 
HIS ND1 HD1  sing N N 281 
HIS CD2 NE2  sing Y N 282 
HIS CD2 HD2  sing N N 283 
HIS CE1 NE2  sing Y N 284 
HIS CE1 HE1  sing N N 285 
HIS NE2 HE2  sing N N 286 
HIS OXT HXT  sing N N 287 
ILE N   CA   sing N N 288 
ILE N   H    sing N N 289 
ILE N   H2   sing N N 290 
ILE CA  C    sing N N 291 
ILE CA  CB   sing N N 292 
ILE CA  HA   sing N N 293 
ILE C   O    doub N N 294 
ILE C   OXT  sing N N 295 
ILE CB  CG1  sing N N 296 
ILE CB  CG2  sing N N 297 
ILE CB  HB   sing N N 298 
ILE CG1 CD1  sing N N 299 
ILE CG1 HG12 sing N N 300 
ILE CG1 HG13 sing N N 301 
ILE CG2 HG21 sing N N 302 
ILE CG2 HG22 sing N N 303 
ILE CG2 HG23 sing N N 304 
ILE CD1 HD11 sing N N 305 
ILE CD1 HD12 sing N N 306 
ILE CD1 HD13 sing N N 307 
ILE OXT HXT  sing N N 308 
LEU N   CA   sing N N 309 
LEU N   H    sing N N 310 
LEU N   H2   sing N N 311 
LEU CA  C    sing N N 312 
LEU CA  CB   sing N N 313 
LEU CA  HA   sing N N 314 
LEU C   O    doub N N 315 
LEU C   OXT  sing N N 316 
LEU CB  CG   sing N N 317 
LEU CB  HB2  sing N N 318 
LEU CB  HB3  sing N N 319 
LEU CG  CD1  sing N N 320 
LEU CG  CD2  sing N N 321 
LEU CG  HG   sing N N 322 
LEU CD1 HD11 sing N N 323 
LEU CD1 HD12 sing N N 324 
LEU CD1 HD13 sing N N 325 
LEU CD2 HD21 sing N N 326 
LEU CD2 HD22 sing N N 327 
LEU CD2 HD23 sing N N 328 
LEU OXT HXT  sing N N 329 
LYS N   CA   sing N N 330 
LYS N   H    sing N N 331 
LYS N   H2   sing N N 332 
LYS CA  C    sing N N 333 
LYS CA  CB   sing N N 334 
LYS CA  HA   sing N N 335 
LYS C   O    doub N N 336 
LYS C   OXT  sing N N 337 
LYS CB  CG   sing N N 338 
LYS CB  HB2  sing N N 339 
LYS CB  HB3  sing N N 340 
LYS CG  CD   sing N N 341 
LYS CG  HG2  sing N N 342 
LYS CG  HG3  sing N N 343 
LYS CD  CE   sing N N 344 
LYS CD  HD2  sing N N 345 
LYS CD  HD3  sing N N 346 
LYS CE  NZ   sing N N 347 
LYS CE  HE2  sing N N 348 
LYS CE  HE3  sing N N 349 
LYS NZ  HZ1  sing N N 350 
LYS NZ  HZ2  sing N N 351 
LYS NZ  HZ3  sing N N 352 
LYS OXT HXT  sing N N 353 
MET N   CA   sing N N 354 
MET N   H    sing N N 355 
MET N   H2   sing N N 356 
MET CA  C    sing N N 357 
MET CA  CB   sing N N 358 
MET CA  HA   sing N N 359 
MET C   O    doub N N 360 
MET C   OXT  sing N N 361 
MET CB  CG   sing N N 362 
MET CB  HB2  sing N N 363 
MET CB  HB3  sing N N 364 
MET CG  SD   sing N N 365 
MET CG  HG2  sing N N 366 
MET CG  HG3  sing N N 367 
MET SD  CE   sing N N 368 
MET CE  HE1  sing N N 369 
MET CE  HE2  sing N N 370 
MET CE  HE3  sing N N 371 
MET OXT HXT  sing N N 372 
OCT C1  C2   sing N N 373 
OCT C1  H11  sing N N 374 
OCT C1  H12  sing N N 375 
OCT C1  H13  sing N N 376 
OCT C2  C3   sing N N 377 
OCT C2  H21  sing N N 378 
OCT C2  H22  sing N N 379 
OCT C3  C4   sing N N 380 
OCT C3  H31  sing N N 381 
OCT C3  H32  sing N N 382 
OCT C4  C5   sing N N 383 
OCT C4  H41  sing N N 384 
OCT C4  H42  sing N N 385 
OCT C5  C6   sing N N 386 
OCT C5  H51  sing N N 387 
OCT C5  H52  sing N N 388 
OCT C6  C7   sing N N 389 
OCT C6  H61  sing N N 390 
OCT C6  H62  sing N N 391 
OCT C7  C8   sing N N 392 
OCT C7  H71  sing N N 393 
OCT C7  H72  sing N N 394 
OCT C8  H81  sing N N 395 
OCT C8  H82  sing N N 396 
OCT C8  H83  sing N N 397 
PHE N   CA   sing N N 398 
PHE N   H    sing N N 399 
PHE N   H2   sing N N 400 
PHE CA  C    sing N N 401 
PHE CA  CB   sing N N 402 
PHE CA  HA   sing N N 403 
PHE C   O    doub N N 404 
PHE C   OXT  sing N N 405 
PHE CB  CG   sing N N 406 
PHE CB  HB2  sing N N 407 
PHE CB  HB3  sing N N 408 
PHE CG  CD1  doub Y N 409 
PHE CG  CD2  sing Y N 410 
PHE CD1 CE1  sing Y N 411 
PHE CD1 HD1  sing N N 412 
PHE CD2 CE2  doub Y N 413 
PHE CD2 HD2  sing N N 414 
PHE CE1 CZ   doub Y N 415 
PHE CE1 HE1  sing N N 416 
PHE CE2 CZ   sing Y N 417 
PHE CE2 HE2  sing N N 418 
PHE CZ  HZ   sing N N 419 
PHE OXT HXT  sing N N 420 
PRO N   CA   sing N N 421 
PRO N   CD   sing N N 422 
PRO N   H    sing N N 423 
PRO CA  C    sing N N 424 
PRO CA  CB   sing N N 425 
PRO CA  HA   sing N N 426 
PRO C   O    doub N N 427 
PRO C   OXT  sing N N 428 
PRO CB  CG   sing N N 429 
PRO CB  HB2  sing N N 430 
PRO CB  HB3  sing N N 431 
PRO CG  CD   sing N N 432 
PRO CG  HG2  sing N N 433 
PRO CG  HG3  sing N N 434 
PRO CD  HD2  sing N N 435 
PRO CD  HD3  sing N N 436 
PRO OXT HXT  sing N N 437 
SER N   CA   sing N N 438 
SER N   H    sing N N 439 
SER N   H2   sing N N 440 
SER CA  C    sing N N 441 
SER CA  CB   sing N N 442 
SER CA  HA   sing N N 443 
SER C   O    doub N N 444 
SER C   OXT  sing N N 445 
SER CB  OG   sing N N 446 
SER CB  HB2  sing N N 447 
SER CB  HB3  sing N N 448 
SER OG  HG   sing N N 449 
SER OXT HXT  sing N N 450 
THR N   CA   sing N N 451 
THR N   H    sing N N 452 
THR N   H2   sing N N 453 
THR CA  C    sing N N 454 
THR CA  CB   sing N N 455 
THR CA  HA   sing N N 456 
THR C   O    doub N N 457 
THR C   OXT  sing N N 458 
THR CB  OG1  sing N N 459 
THR CB  CG2  sing N N 460 
THR CB  HB   sing N N 461 
THR OG1 HG1  sing N N 462 
THR CG2 HG21 sing N N 463 
THR CG2 HG22 sing N N 464 
THR CG2 HG23 sing N N 465 
THR OXT HXT  sing N N 466 
TRP N   CA   sing N N 467 
TRP N   H    sing N N 468 
TRP N   H2   sing N N 469 
TRP CA  C    sing N N 470 
TRP CA  CB   sing N N 471 
TRP CA  HA   sing N N 472 
TRP C   O    doub N N 473 
TRP C   OXT  sing N N 474 
TRP CB  CG   sing N N 475 
TRP CB  HB2  sing N N 476 
TRP CB  HB3  sing N N 477 
TRP CG  CD1  doub Y N 478 
TRP CG  CD2  sing Y N 479 
TRP CD1 NE1  sing Y N 480 
TRP CD1 HD1  sing N N 481 
TRP CD2 CE2  doub Y N 482 
TRP CD2 CE3  sing Y N 483 
TRP NE1 CE2  sing Y N 484 
TRP NE1 HE1  sing N N 485 
TRP CE2 CZ2  sing Y N 486 
TRP CE3 CZ3  doub Y N 487 
TRP CE3 HE3  sing N N 488 
TRP CZ2 CH2  doub Y N 489 
TRP CZ2 HZ2  sing N N 490 
TRP CZ3 CH2  sing Y N 491 
TRP CZ3 HZ3  sing N N 492 
TRP CH2 HH2  sing N N 493 
TRP OXT HXT  sing N N 494 
TYR N   CA   sing N N 495 
TYR N   H    sing N N 496 
TYR N   H2   sing N N 497 
TYR CA  C    sing N N 498 
TYR CA  CB   sing N N 499 
TYR CA  HA   sing N N 500 
TYR C   O    doub N N 501 
TYR C   OXT  sing N N 502 
TYR CB  CG   sing N N 503 
TYR CB  HB2  sing N N 504 
TYR CB  HB3  sing N N 505 
TYR CG  CD1  doub Y N 506 
TYR CG  CD2  sing Y N 507 
TYR CD1 CE1  sing Y N 508 
TYR CD1 HD1  sing N N 509 
TYR CD2 CE2  doub Y N 510 
TYR CD2 HD2  sing N N 511 
TYR CE1 CZ   doub Y N 512 
TYR CE1 HE1  sing N N 513 
TYR CE2 CZ   sing Y N 514 
TYR CE2 HE2  sing N N 515 
TYR CZ  OH   sing N N 516 
TYR OH  HH   sing N N 517 
TYR OXT HXT  sing N N 518 
VAL N   CA   sing N N 519 
VAL N   H    sing N N 520 
VAL N   H2   sing N N 521 
VAL CA  C    sing N N 522 
VAL CA  CB   sing N N 523 
VAL CA  HA   sing N N 524 
VAL C   O    doub N N 525 
VAL C   OXT  sing N N 526 
VAL CB  CG1  sing N N 527 
VAL CB  CG2  sing N N 528 
VAL CB  HB   sing N N 529 
VAL CG1 HG11 sing N N 530 
VAL CG1 HG12 sing N N 531 
VAL CG1 HG13 sing N N 532 
VAL CG2 HG21 sing N N 533 
VAL CG2 HG22 sing N N 534 
VAL CG2 HG23 sing N N 535 
VAL OXT HXT  sing N N 536 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-24 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9C09 
_em_admin.last_update        2025-06-04 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Structure of K2P13.1 (THIK1) S136P in lipid nanodisc' 
# 
loop_
_em_buffer_component.buffer_id 
_em_buffer_component.concentration 
_em_buffer_component.concentration_units 
_em_buffer_component.formula 
_em_buffer_component.id 
_em_buffer_component.name 
1 200 mM KCl 1 'Potassium Chloride' 
1 20  mM ?   2 Tris                 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                MEGADALTONS 
_em_entity_assembly_molwt.value                0.080 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 Expi293F 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         50 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?         ?   
'IMAGE ACQUISITION'             ? 2  ? ? 1 ?         ?   
MASKING                         ? 3  ? ? ? ?         ?   
'CTF CORRECTION'                ? 4  1 ? ? cryoSPARC 3.2 
'LAYERLINE INDEXING'            ? 5  ? ? ? ?         ?   
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?         ?   
'MODEL FITTING'                 ? 7  ? ? ? ?         ?   
'MODEL REFINEMENT'              ? 8  ? ? ? PHENIX    ?   
OTHER                           ? 9  ? ? ? ?         ?   
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?         ?   
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?         ?   
CLASSIFICATION                  ? 12 1 ? ? ?         ?   
RECONSTRUCTION                  ? 13 1 ? ? cryoSPARC 3.2 
'VOLUME SELECTION'              ? 14 1 1 1 ?         ?   
'SERIES ALIGNMENT'              ? 15 1 1 1 ?         ?   
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?         ?   
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?         ?   
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?         ?   
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?         ?   
# 
_em_specimen.concentration           1 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Institute of Mental Health (NIH/NIMH)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           'R01 MH093603' 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9C09 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
K 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ASN A 1 14  ? 123.531 144.856 100.933 1.00 48.27  ? 14  ASN U N    1 
ATOM   2    C CA   . ASN A 1 14  ? 122.858 145.692 101.920 1.00 49.40  ? 14  ASN U CA   1 
ATOM   3    C C    . ASN A 1 14  ? 121.682 144.956 102.555 1.00 52.70  ? 14  ASN U C    1 
ATOM   4    O O    . ASN A 1 14  ? 121.263 145.282 103.666 1.00 55.80  ? 14  ASN U O    1 
ATOM   5    C CB   . ASN A 1 14  ? 122.377 146.996 101.277 1.00 48.97  ? 14  ASN U CB   1 
ATOM   6    C CG   . ASN A 1 14  ? 122.006 148.050 102.303 1.00 50.85  ? 14  ASN U CG   1 
ATOM   7    O OD1  . ASN A 1 14  ? 122.384 147.959 103.469 1.00 54.21  ? 14  ASN U OD1  1 
ATOM   8    N ND2  . ASN A 1 14  ? 121.266 149.062 101.867 1.00 48.60  ? 14  ASN U ND2  1 
ATOM   9    N N    . GLU A 1 15  ? 121.159 143.960 101.843 1.00 52.15  ? 15  GLU U N    1 
ATOM   10   C CA   . GLU A 1 15  ? 120.075 143.148 102.389 1.00 50.18  ? 15  GLU U CA   1 
ATOM   11   C C    . GLU A 1 15  ? 120.540 142.316 103.578 1.00 55.43  ? 15  GLU U C    1 
ATOM   12   O O    . GLU A 1 15  ? 119.822 142.200 104.578 1.00 58.18  ? 15  GLU U O    1 
ATOM   13   C CB   . GLU A 1 15  ? 119.500 142.246 101.294 1.00 50.79  ? 15  GLU U CB   1 
ATOM   14   C CG   . GLU A 1 15  ? 118.341 141.377 101.744 1.00 57.29  ? 15  GLU U CG   1 
ATOM   15   C CD   . GLU A 1 15  ? 117.680 140.647 100.591 1.00 64.07  ? 15  GLU U CD   1 
ATOM   16   O OE1  . GLU A 1 15  ? 118.003 140.959 99.425  1.00 61.66  ? 15  GLU U OE1  1 
ATOM   17   O OE2  . GLU A 1 15  ? 116.837 139.764 100.849 1.00 61.07  ? 15  GLU U OE2  1 
ATOM   18   N N    . ASP A 1 16  ? 121.737 141.729 103.487 1.00 48.98  ? 16  ASP U N    1 
ATOM   19   C CA   . ASP A 1 16  ? 122.247 140.920 104.590 1.00 45.37  ? 16  ASP U CA   1 
ATOM   20   C C    . ASP A 1 16  ? 122.491 141.763 105.837 1.00 49.30  ? 16  ASP U C    1 
ATOM   21   O O    . ASP A 1 16  ? 122.154 141.343 106.952 1.00 52.79  ? 16  ASP U O    1 
ATOM   22   C CB   . ASP A 1 16  ? 123.533 140.212 104.163 1.00 46.82  ? 16  ASP U CB   1 
ATOM   23   C CG   . ASP A 1 16  ? 123.331 139.314 102.959 1.00 54.45  ? 16  ASP U CG   1 
ATOM   24   O OD1  . ASP A 1 16  ? 122.213 138.775 102.797 1.00 60.31  ? 16  ASP U OD1  1 
ATOM   25   O OD2  . ASP A 1 16  ? 124.283 139.146 102.173 1.00 54.88  ? 16  ASP U OD2  1 
ATOM   26   N N    . ASN A 1 17  ? 123.074 142.952 105.670 1.00 42.19  ? 17  ASN U N    1 
ATOM   27   C CA   . ASN A 1 17  ? 123.293 143.837 106.812 1.00 43.07  ? 17  ASN U CA   1 
ATOM   28   C C    . ASN A 1 17  ? 121.971 144.275 107.434 1.00 44.88  ? 17  ASN U C    1 
ATOM   29   O O    . ASN A 1 17  ? 121.839 144.326 108.664 1.00 47.13  ? 17  ASN U O    1 
ATOM   30   C CB   . ASN A 1 17  ? 124.111 145.052 106.383 1.00 44.14  ? 17  ASN U CB   1 
ATOM   31   C CG   . ASN A 1 17  ? 125.455 144.672 105.793 1.00 48.51  ? 17  ASN U CG   1 
ATOM   32   O OD1  . ASN A 1 17  ? 125.973 143.585 106.048 1.00 49.95  ? 17  ASN U OD1  1 
ATOM   33   N ND2  . ASN A 1 17  ? 126.026 145.568 105.000 1.00 49.95  ? 17  ASN U ND2  1 
ATOM   34   N N    . ALA A 1 18  ? 120.982 144.602 106.598 1.00 38.76  ? 18  ALA U N    1 
ATOM   35   C CA   . ALA A 1 18  ? 119.676 145.000 107.109 1.00 38.06  ? 18  ALA U CA   1 
ATOM   36   C C    . ALA A 1 18  ? 119.021 143.864 107.885 1.00 39.81  ? 18  ALA U C    1 
ATOM   37   O O    . ALA A 1 18  ? 118.435 144.090 108.951 1.00 42.67  ? 18  ALA U O    1 
ATOM   38   C CB   . ALA A 1 18  ? 118.779 145.455 105.959 1.00 33.74  ? 18  ALA U CB   1 
ATOM   39   N N    . ARG A 1 19  ? 119.108 142.639 107.366 1.00 34.63  ? 19  ARG U N    1 
ATOM   40   C CA   . ARG A 1 19  ? 118.529 141.492 108.060 1.00 30.87  ? 19  ARG U CA   1 
ATOM   41   C C    . ARG A 1 19  ? 119.234 141.240 109.388 1.00 34.61  ? 19  ARG U C    1 
ATOM   42   O O    . ARG A 1 19  ? 118.582 140.955 110.402 1.00 42.85  ? 19  ARG U O    1 
ATOM   43   C CB   . ARG A 1 19  ? 118.600 140.260 107.157 1.00 31.42  ? 19  ARG U CB   1 
ATOM   44   C CG   . ARG A 1 19  ? 118.341 138.939 107.854 1.00 37.38  ? 19  ARG U CG   1 
ATOM   45   C CD   . ARG A 1 19  ? 117.892 137.885 106.857 1.00 36.51  ? 19  ARG U CD   1 
ATOM   46   N NE   . ARG A 1 19  ? 119.005 137.378 106.065 1.00 36.86  ? 19  ARG U NE   1 
ATOM   47   C CZ   . ARG A 1 19  ? 119.120 137.531 104.752 1.00 37.54  ? 19  ARG U CZ   1 
ATOM   48   N NH1  . ARG A 1 19  ? 118.195 138.162 104.048 1.00 34.74  ? 19  ARG U NH1  1 
ATOM   49   N NH2  . ARG A 1 19  ? 120.187 137.038 104.131 1.00 40.47  ? 19  ARG U NH2  1 
ATOM   50   N N    . PHE A 1 20  ? 120.563 141.361 109.405 1.00 29.70  ? 20  PHE U N    1 
ATOM   51   C CA   . PHE A 1 20  ? 121.326 141.196 110.640 1.00 26.81  ? 20  PHE U CA   1 
ATOM   52   C C    . PHE A 1 20  ? 120.906 142.225 111.686 1.00 32.87  ? 20  PHE U C    1 
ATOM   53   O O    . PHE A 1 20  ? 120.652 141.887 112.852 1.00 36.54  ? 20  PHE U O    1 
ATOM   54   C CB   . PHE A 1 20  ? 122.818 141.310 110.324 1.00 21.11  ? 20  PHE U CB   1 
ATOM   55   C CG   . PHE A 1 20  ? 123.719 140.688 111.351 1.00 27.72  ? 20  PHE U CG   1 
ATOM   56   C CD1  . PHE A 1 20  ? 123.463 139.416 111.837 1.00 32.30  ? 20  PHE U CD1  1 
ATOM   57   C CD2  . PHE A 1 20  ? 124.826 141.373 111.823 1.00 28.11  ? 20  PHE U CD2  1 
ATOM   58   C CE1  . PHE A 1 20  ? 124.293 138.842 112.776 1.00 32.73  ? 20  PHE U CE1  1 
ATOM   59   C CE2  . PHE A 1 20  ? 125.658 140.800 112.766 1.00 25.27  ? 20  PHE U CE2  1 
ATOM   60   C CZ   . PHE A 1 20  ? 125.391 139.535 113.241 1.00 24.88  ? 20  PHE U CZ   1 
ATOM   61   N N    . LEU A 1 21  ? 120.806 143.495 111.274 1.00 33.51  ? 21  LEU U N    1 
ATOM   62   C CA   . LEU A 1 21  ? 120.413 144.556 112.196 1.00 28.60  ? 21  LEU U CA   1 
ATOM   63   C C    . LEU A 1 21  ? 118.992 144.356 112.712 1.00 31.54  ? 21  LEU U C    1 
ATOM   64   O O    . LEU A 1 21  ? 118.725 144.537 113.908 1.00 39.00  ? 21  LEU U O    1 
ATOM   65   C CB   . LEU A 1 21  ? 120.552 145.914 111.506 1.00 29.28  ? 21  LEU U CB   1 
ATOM   66   C CG   . LEU A 1 21  ? 120.341 147.164 112.362 1.00 30.43  ? 21  LEU U CG   1 
ATOM   67   C CD1  . LEU A 1 21  ? 121.476 147.337 113.361 1.00 32.98  ? 21  LEU U CD1  1 
ATOM   68   C CD2  . LEU A 1 21  ? 120.212 148.392 111.479 1.00 27.51  ? 21  LEU U CD2  1 
ATOM   69   N N    . LEU A 1 22  ? 118.067 143.988 111.821 1.00 29.19  ? 22  LEU U N    1 
ATOM   70   C CA   . LEU A 1 22  ? 116.686 143.771 112.234 1.00 30.59  ? 22  LEU U CA   1 
ATOM   71   C C    . LEU A 1 22  ? 116.584 142.630 113.235 1.00 34.37  ? 22  LEU U C    1 
ATOM   72   O O    . LEU A 1 22  ? 115.868 142.735 114.239 1.00 39.94  ? 22  LEU U O    1 
ATOM   73   C CB   . LEU A 1 22  ? 115.808 143.490 111.017 1.00 29.61  ? 22  LEU U CB   1 
ATOM   74   C CG   . LEU A 1 22  ? 114.315 143.319 111.307 1.00 33.54  ? 22  LEU U CG   1 
ATOM   75   C CD1  . LEU A 1 22  ? 113.698 144.633 111.766 1.00 30.66  ? 22  LEU U CD1  1 
ATOM   76   C CD2  . LEU A 1 22  ? 113.584 142.768 110.097 1.00 32.29  ? 22  LEU U CD2  1 
ATOM   77   N N    . LEU A 1 23  ? 117.294 141.527 112.979 1.00 23.98  ? 23  LEU U N    1 
ATOM   78   C CA   . LEU A 1 23  ? 117.263 140.405 113.909 1.00 19.61  ? 23  LEU U CA   1 
ATOM   79   C C    . LEU A 1 23  ? 117.836 140.802 115.263 1.00 29.54  ? 23  LEU U C    1 
ATOM   80   O O    . LEU A 1 23  ? 117.292 140.425 116.307 1.00 34.17  ? 23  LEU U O    1 
ATOM   81   C CB   . LEU A 1 23  ? 118.019 139.215 113.321 1.00 20.47  ? 23  LEU U CB   1 
ATOM   82   C CG   . LEU A 1 23  ? 117.975 137.903 114.107 1.00 25.91  ? 23  LEU U CG   1 
ATOM   83   C CD1  . LEU A 1 23  ? 116.539 137.503 114.410 1.00 26.48  ? 23  LEU U CD1  1 
ATOM   84   C CD2  . LEU A 1 23  ? 118.688 136.796 113.349 1.00 23.99  ? 23  LEU U CD2  1 
ATOM   85   N N    . ALA A 1 24  ? 118.931 141.566 115.269 1.00 30.70  ? 24  ALA U N    1 
ATOM   86   C CA   . ALA A 1 24  ? 119.509 142.003 116.538 1.00 22.62  ? 24  ALA U CA   1 
ATOM   87   C C    . ALA A 1 24  ? 118.526 142.865 117.327 1.00 32.25  ? 24  ALA U C    1 
ATOM   88   O O    . ALA A 1 24  ? 118.341 142.672 118.537 1.00 37.20  ? 24  ALA U O    1 
ATOM   89   C CB   . ALA A 1 24  ? 120.812 142.762 116.284 1.00 21.25  ? 24  ALA U CB   1 
ATOM   90   N N    . ALA A 1 25  ? 117.877 143.818 116.652 1.00 26.31  ? 25  ALA U N    1 
ATOM   91   C CA   . ALA A 1 25  ? 116.911 144.682 117.333 1.00 23.99  ? 25  ALA U CA   1 
ATOM   92   C C    . ALA A 1 25  ? 115.731 143.883 117.876 1.00 28.09  ? 25  ALA U C    1 
ATOM   93   O O    . ALA A 1 25  ? 115.271 144.114 119.005 1.00 32.90  ? 25  ALA U O    1 
ATOM   94   C CB   . ALA A 1 25  ? 116.433 145.782 116.389 1.00 21.78  ? 25  ALA U CB   1 
ATOM   95   N N    . LEU A 1 26  ? 115.220 142.936 117.082 1.00 29.17  ? 26  LEU U N    1 
ATOM   96   C CA   . LEU A 1 26  ? 114.097 142.122 117.535 1.00 23.92  ? 26  LEU U CA   1 
ATOM   97   C C    . LEU A 1 26  ? 114.480 141.289 118.749 1.00 24.26  ? 26  LEU U C    1 
ATOM   98   O O    . LEU A 1 26  ? 113.690 141.158 119.692 1.00 30.98  ? 26  LEU U O    1 
ATOM   99   C CB   . LEU A 1 26  ? 113.595 141.223 116.405 1.00 27.11  ? 26  LEU U CB   1 
ATOM   100  C CG   . LEU A 1 26  ? 112.928 141.910 115.212 1.00 22.14  ? 26  LEU U CG   1 
ATOM   101  C CD1  . LEU A 1 26  ? 112.472 140.882 114.190 1.00 24.28  ? 26  LEU U CD1  1 
ATOM   102  C CD2  . LEU A 1 26  ? 111.759 142.765 115.670 1.00 22.97  ? 26  LEU U CD2  1 
ATOM   103  N N    . ILE A 1 27  ? 115.686 140.717 118.747 1.00 20.22  ? 27  ILE U N    1 
ATOM   104  C CA   . ILE A 1 27  ? 116.124 139.923 119.891 1.00 22.32  ? 27  ILE U CA   1 
ATOM   105  C C    . ILE A 1 27  ? 116.264 140.799 121.132 1.00 23.54  ? 27  ILE U C    1 
ATOM   106  O O    . ILE A 1 27  ? 115.930 140.376 122.245 1.00 26.84  ? 27  ILE U O    1 
ATOM   107  C CB   . ILE A 1 27  ? 117.429 139.175 119.562 1.00 25.96  ? 27  ILE U CB   1 
ATOM   108  C CG1  . ILE A 1 27  ? 117.182 138.143 118.462 1.00 20.46  ? 27  ILE U CG1  1 
ATOM   109  C CG2  . ILE A 1 27  ? 117.976 138.481 120.800 1.00 25.61  ? 27  ILE U CG2  1 
ATOM   110  C CD1  . ILE A 1 27  ? 118.419 137.388 118.036 1.00 15.42  ? 27  ILE U CD1  1 
ATOM   111  N N    . VAL A 1 28  ? 116.756 142.028 120.966 1.00 26.91  ? 28  VAL U N    1 
ATOM   112  C CA   . VAL A 1 28  ? 116.892 142.928 122.113 1.00 25.99  ? 28  VAL U CA   1 
ATOM   113  C C    . VAL A 1 28  ? 115.521 143.240 122.717 1.00 25.12  ? 28  VAL U C    1 
ATOM   114  O O    . VAL A 1 28  ? 115.332 143.186 123.943 1.00 29.86  ? 28  VAL U O    1 
ATOM   115  C CB   . VAL A 1 28  ? 117.630 144.215 121.703 1.00 25.85  ? 28  VAL U CB   1 
ATOM   116  C CG1  . VAL A 1 28  ? 117.517 145.271 122.790 1.00 23.70  ? 28  VAL U CG1  1 
ATOM   117  C CG2  . VAL A 1 28  ? 119.094 143.914 121.415 1.00 26.03  ? 28  VAL U CG2  1 
ATOM   118  N N    . LEU A 1 29  ? 114.545 143.564 121.864 1.00 21.20  ? 29  LEU U N    1 
ATOM   119  C CA   . LEU A 1 29  ? 113.198 143.837 122.365 1.00 24.21  ? 29  LEU U CA   1 
ATOM   120  C C    . LEU A 1 29  ? 112.593 142.603 123.031 1.00 29.63  ? 29  LEU U C    1 
ATOM   121  O O    . LEU A 1 29  ? 111.925 142.708 124.071 1.00 33.14  ? 29  LEU U O    1 
ATOM   122  C CB   . LEU A 1 29  ? 112.302 144.330 121.229 1.00 24.15  ? 29  LEU U CB   1 
ATOM   123  C CG   . LEU A 1 29  ? 112.622 145.707 120.649 1.00 26.48  ? 29  LEU U CG   1 
ATOM   124  C CD1  . LEU A 1 29  ? 111.600 146.096 119.599 1.00 22.50  ? 29  LEU U CD1  1 
ATOM   125  C CD2  . LEU A 1 29  ? 112.678 146.753 121.747 1.00 25.49  ? 29  LEU U CD2  1 
ATOM   126  N N    . TYR A 1 30  ? 112.824 141.427 122.443 1.00 23.79  ? 30  TYR U N    1 
ATOM   127  C CA   . TYR A 1 30  ? 112.350 140.173 123.022 1.00 18.29  ? 30  TYR U CA   1 
ATOM   128  C C    . TYR A 1 30  ? 112.916 139.974 124.418 1.00 22.71  ? 30  TYR U C    1 
ATOM   129  O O    . TYR A 1 30  ? 112.194 139.601 125.349 1.00 25.94  ? 30  TYR U O    1 
ATOM   130  C CB   . TYR A 1 30  ? 112.733 139.012 122.100 1.00 16.48  ? 30  TYR U CB   1 
ATOM   131  C CG   . TYR A 1 30  ? 112.015 137.710 122.373 1.00 24.49  ? 30  TYR U CG   1 
ATOM   132  C CD1  . TYR A 1 30  ? 110.653 137.579 122.136 1.00 18.12  ? 30  TYR U CD1  1 
ATOM   133  C CD2  . TYR A 1 30  ? 112.705 136.602 122.846 1.00 18.31  ? 30  TYR U CD2  1 
ATOM   134  C CE1  . TYR A 1 30  ? 109.997 136.386 122.377 1.00 14.14  ? 30  TYR U CE1  1 
ATOM   135  C CE2  . TYR A 1 30  ? 112.060 135.406 123.087 1.00 19.90  ? 30  TYR U CE2  1 
ATOM   136  C CZ   . TYR A 1 30  ? 110.706 135.303 122.852 1.00 17.66  ? 30  TYR U CZ   1 
ATOM   137  O OH   . TYR A 1 30  ? 110.061 134.113 123.093 1.00 26.50  ? 30  TYR U OH   1 
ATOM   138  N N    . LEU A 1 31  ? 114.219 140.218 124.579 1.00 16.39  ? 31  LEU U N    1 
ATOM   139  C CA   . LEU A 1 31  ? 114.856 140.049 125.880 1.00 17.55  ? 31  LEU U CA   1 
ATOM   140  C C    . LEU A 1 31  ? 114.275 141.011 126.906 1.00 19.44  ? 31  LEU U C    1 
ATOM   141  O O    . LEU A 1 31  ? 114.012 140.620 128.052 1.00 25.50  ? 31  LEU U O    1 
ATOM   142  C CB   . LEU A 1 31  ? 116.369 140.251 125.757 1.00 15.56  ? 31  LEU U CB   1 
ATOM   143  C CG   . LEU A 1 31  ? 117.164 139.172 125.024 1.00 18.48  ? 31  LEU U CG   1 
ATOM   144  C CD1  . LEU A 1 31  ? 118.643 139.521 125.004 1.00 19.73  ? 31  LEU U CD1  1 
ATOM   145  C CD2  . LEU A 1 31  ? 116.943 137.810 125.661 1.00 18.02  ? 31  LEU U CD2  1 
ATOM   146  N N    . LEU A 1 32  ? 114.077 142.278 126.523 1.00 15.48  ? 32  LEU U N    1 
ATOM   147  C CA   . LEU A 1 32  ? 113.521 143.244 127.468 1.00 18.65  ? 32  LEU U CA   1 
ATOM   148  C C    . LEU A 1 32  ? 112.121 142.835 127.928 1.00 23.67  ? 32  LEU U C    1 
ATOM   149  O O    . LEU A 1 32  ? 111.821 142.832 129.132 1.00 25.59  ? 32  LEU U O    1 
ATOM   150  C CB   . LEU A 1 32  ? 113.499 144.637 126.842 1.00 19.60  ? 32  LEU U CB   1 
ATOM   151  C CG   . LEU A 1 32  ? 114.845 145.319 126.586 1.00 18.68  ? 32  LEU U CG   1 
ATOM   152  C CD1  . LEU A 1 32  ? 114.644 146.670 125.919 1.00 21.50  ? 32  LEU U CD1  1 
ATOM   153  C CD2  . LEU A 1 32  ? 115.629 145.480 127.877 1.00 19.75  ? 32  LEU U CD2  1 
ATOM   154  N N    . GLY A 1 33  ? 111.256 142.474 126.976 1.00 23.93  ? 33  GLY U N    1 
ATOM   155  C CA   . GLY A 1 33  ? 109.907 142.065 127.347 1.00 19.21  ? 33  GLY U CA   1 
ATOM   156  C C    . GLY A 1 33  ? 109.887 140.815 128.202 1.00 25.72  ? 33  GLY U C    1 
ATOM   157  O O    . GLY A 1 33  ? 109.137 140.725 129.184 1.00 28.82  ? 33  GLY U O    1 
ATOM   158  N N    . GLY A 1 34  ? 110.725 139.835 127.855 1.00 21.95  ? 34  GLY U N    1 
ATOM   159  C CA   . GLY A 1 34  ? 110.786 138.616 128.640 1.00 19.04  ? 34  GLY U CA   1 
ATOM   160  C C    . GLY A 1 34  ? 111.261 138.860 130.054 1.00 22.99  ? 34  GLY U C    1 
ATOM   161  O O    . GLY A 1 34  ? 110.744 138.263 131.004 1.00 28.58  ? 34  GLY U O    1 
ATOM   162  N N    . ALA A 1 35  ? 112.265 139.727 130.219 1.00 18.55  ? 35  ALA U N    1 
ATOM   163  C CA   . ALA A 1 35  ? 112.715 140.072 131.563 1.00 17.78  ? 35  ALA U CA   1 
ATOM   164  C C    . ALA A 1 35  ? 111.600 140.719 132.374 1.00 20.26  ? 35  ALA U C    1 
ATOM   165  O O    . ALA A 1 35  ? 111.392 140.365 133.544 1.00 21.41  ? 35  ALA U O    1 
ATOM   166  C CB   . ALA A 1 35  ? 113.926 140.999 131.484 1.00 15.61  ? 35  ALA U CB   1 
ATOM   167  N N    . ALA A 1 36  ? 110.866 141.661 131.772 1.00 24.22  ? 36  ALA U N    1 
ATOM   168  C CA   . ALA A 1 36  ? 109.788 142.314 132.515 1.00 19.42  ? 36  ALA U CA   1 
ATOM   169  C C    . ALA A 1 36  ? 108.721 141.309 132.947 1.00 25.75  ? 36  ALA U C    1 
ATOM   170  O O    . ALA A 1 36  ? 108.282 141.313 134.111 1.00 28.08  ? 36  ALA U O    1 
ATOM   171  C CB   . ALA A 1 36  ? 109.164 143.424 131.669 1.00 22.29  ? 36  ALA U CB   1 
ATOM   172  N N    . VAL A 1 37  ? 108.393 140.359 132.066 1.00 29.56  ? 37  VAL U N    1 
ATOM   173  C CA   . VAL A 1 37  ? 107.361 139.385 132.403 1.00 25.58  ? 37  VAL U CA   1 
ATOM   174  C C    . VAL A 1 37  ? 107.853 138.438 133.490 1.00 24.97  ? 37  VAL U C    1 
ATOM   175  O O    . VAL A 1 37  ? 107.125 138.138 134.444 1.00 29.03  ? 37  VAL U O    1 
ATOM   176  C CB   . VAL A 1 37  ? 106.907 138.623 131.145 1.00 24.01  ? 37  VAL U CB   1 
ATOM   177  C CG1  . VAL A 1 37  ? 105.946 137.506 131.518 1.00 26.26  ? 37  VAL U CG1  1 
ATOM   178  C CG2  . VAL A 1 37  ? 106.257 139.577 130.157 1.00 23.89  ? 37  VAL U CG2  1 
ATOM   179  N N    . PHE A 1 38  ? 109.088 137.941 133.363 1.00 26.03  ? 38  PHE U N    1 
ATOM   180  C CA   . PHE A 1 38  ? 109.568 136.964 134.332 1.00 20.23  ? 38  PHE U CA   1 
ATOM   181  C C    . PHE A 1 38  ? 109.685 137.598 135.711 1.00 25.81  ? 38  PHE U C    1 
ATOM   182  O O    . PHE A 1 38  ? 109.350 136.967 136.726 1.00 27.73  ? 38  PHE U O    1 
ATOM   183  C CB   . PHE A 1 38  ? 110.915 136.392 133.883 1.00 13.33  ? 38  PHE U CB   1 
ATOM   184  C CG   . PHE A 1 38  ? 110.801 135.135 133.069 1.00 21.63  ? 38  PHE U CG   1 
ATOM   185  C CD1  . PHE A 1 38  ? 110.349 133.959 133.641 1.00 21.49  ? 38  PHE U CD1  1 
ATOM   186  C CD2  . PHE A 1 38  ? 111.157 135.128 131.731 1.00 24.34  ? 38  PHE U CD2  1 
ATOM   187  C CE1  . PHE A 1 38  ? 110.248 132.802 132.891 1.00 22.92  ? 38  PHE U CE1  1 
ATOM   188  C CE2  . PHE A 1 38  ? 111.058 133.975 130.976 1.00 17.80  ? 38  PHE U CE2  1 
ATOM   189  C CZ   . PHE A 1 38  ? 110.602 132.812 131.559 1.00 19.75  ? 38  PHE U CZ   1 
ATOM   190  N N    . SER A 1 39  ? 110.176 138.841 135.772 1.00 24.94  ? 39  SER U N    1 
ATOM   191  C CA   . SER A 1 39  ? 110.292 139.522 137.056 1.00 24.27  ? 39  SER U CA   1 
ATOM   192  C C    . SER A 1 39  ? 108.924 139.689 137.701 1.00 28.42  ? 39  SER U C    1 
ATOM   193  O O    . SER A 1 39  ? 108.753 139.409 138.899 1.00 35.29  ? 39  SER U O    1 
ATOM   194  C CB   . SER A 1 39  ? 110.976 140.875 136.881 1.00 25.94  ? 39  SER U CB   1 
ATOM   195  O OG   . SER A 1 39  ? 110.084 141.841 136.356 1.00 34.73  ? 39  SER U OG   1 
ATOM   196  N N    . ALA A 1 40  ? 107.926 140.104 136.911 1.00 29.29  ? 40  ALA U N    1 
ATOM   197  C CA   . ALA A 1 40  ? 106.581 140.256 137.461 1.00 26.51  ? 40  ALA U CA   1 
ATOM   198  C C    . ALA A 1 40  ? 106.006 138.919 137.916 1.00 26.22  ? 40  ALA U C    1 
ATOM   199  O O    . ALA A 1 40  ? 105.215 138.874 138.866 1.00 31.74  ? 40  ALA U O    1 
ATOM   200  C CB   . ALA A 1 40  ? 105.659 140.903 136.430 1.00 25.88  ? 40  ALA U CB   1 
ATOM   201  N N    . LEU A 1 41  ? 106.388 137.827 137.255 1.00 28.45  ? 41  LEU U N    1 
ATOM   202  C CA   . LEU A 1 41  ? 105.888 136.511 137.645 1.00 21.31  ? 41  LEU U CA   1 
ATOM   203  C C    . LEU A 1 41  ? 106.541 135.989 138.924 1.00 28.69  ? 41  LEU U C    1 
ATOM   204  O O    . LEU A 1 41  ? 105.898 135.255 139.681 1.00 31.40  ? 41  LEU U O    1 
ATOM   205  C CB   . LEU A 1 41  ? 106.098 135.514 136.507 1.00 22.20  ? 41  LEU U CB   1 
ATOM   206  C CG   . LEU A 1 41  ? 105.063 135.522 135.379 1.00 23.22  ? 41  LEU U CG   1 
ATOM   207  C CD1  . LEU A 1 41  ? 105.448 134.525 134.296 1.00 22.26  ? 41  LEU U CD1  1 
ATOM   208  C CD2  . LEU A 1 41  ? 103.670 135.225 135.913 1.00 21.74  ? 41  LEU U CD2  1 
ATOM   209  N N    . GLU A 1 42  ? 107.806 136.336 139.184 1.00 35.69  ? 42  GLU U N    1 
ATOM   210  C CA   . GLU A 1 42  ? 108.578 135.622 140.199 1.00 27.14  ? 42  GLU U CA   1 
ATOM   211  C C    . GLU A 1 42  ? 108.985 136.428 141.431 1.00 31.09  ? 42  GLU U C    1 
ATOM   212  O O    . GLU A 1 42  ? 109.420 135.815 142.425 1.00 38.35  ? 42  GLU U O    1 
ATOM   213  C CB   . GLU A 1 42  ? 109.840 135.027 139.559 1.00 30.11  ? 42  GLU U CB   1 
ATOM   214  C CG   . GLU A 1 42  ? 109.561 134.069 138.415 1.00 24.31  ? 42  GLU U CG   1 
ATOM   215  C CD   . GLU A 1 42  ? 109.304 132.652 138.891 1.00 34.71  ? 42  GLU U CD   1 
ATOM   216  O OE1  . GLU A 1 42  ? 109.741 132.309 140.009 1.00 44.20  ? 42  GLU U OE1  1 
ATOM   217  O OE2  . GLU A 1 42  ? 108.665 131.880 138.147 1.00 40.12  ? 42  GLU U OE2  1 
ATOM   218  N N    . LEU A 1 43  ? 108.883 137.762 141.409 1.00 30.46  ? 43  LEU U N    1 
ATOM   219  C CA   . LEU A 1 43  ? 109.464 138.550 142.496 1.00 31.98  ? 43  LEU U CA   1 
ATOM   220  C C    . LEU A 1 43  ? 108.805 138.262 143.846 1.00 37.33  ? 43  LEU U C    1 
ATOM   221  O O    . LEU A 1 43  ? 109.496 138.150 144.870 1.00 42.57  ? 43  LEU U O    1 
ATOM   222  C CB   . LEU A 1 43  ? 109.363 140.040 142.169 1.00 36.61  ? 43  LEU U CB   1 
ATOM   223  C CG   . LEU A 1 43  ? 110.275 140.990 142.948 1.00 35.57  ? 43  LEU U CG   1 
ATOM   224  C CD1  . LEU A 1 43  ? 111.667 140.407 143.121 1.00 35.64  ? 43  LEU U CD1  1 
ATOM   225  C CD2  . LEU A 1 43  ? 110.344 142.346 142.268 1.00 35.43  ? 43  LEU U CD2  1 
ATOM   226  N N    . ALA A 1 44  ? 107.472 138.163 143.874 1.00 37.81  ? 44  ALA U N    1 
ATOM   227  C CA   . ALA A 1 44  ? 106.777 137.954 145.144 1.00 35.37  ? 44  ALA U CA   1 
ATOM   228  C C    . ALA A 1 44  ? 107.139 136.611 145.765 1.00 44.06  ? 44  ALA U C    1 
ATOM   229  O O    . ALA A 1 44  ? 107.375 136.520 146.979 1.00 50.82  ? 44  ALA U O    1 
ATOM   230  C CB   . ALA A 1 44  ? 105.266 138.055 144.935 1.00 39.18  ? 44  ALA U CB   1 
ATOM   231  N N    . HIS A 1 45  ? 107.195 135.557 144.947 1.00 42.55  ? 45  HIS U N    1 
ATOM   232  C CA   . HIS A 1 45  ? 107.599 134.246 145.446 1.00 40.82  ? 45  HIS U CA   1 
ATOM   233  C C    . HIS A 1 45  ? 109.021 134.286 145.989 1.00 46.14  ? 45  HIS U C    1 
ATOM   234  O O    . HIS A 1 45  ? 109.312 133.696 147.039 1.00 50.96  ? 45  HIS U O    1 
ATOM   235  C CB   . HIS A 1 45  ? 107.469 133.197 144.341 1.00 44.64  ? 45  HIS U CB   1 
ATOM   236  C CG   . HIS A 1 45  ? 107.669 131.793 144.819 1.00 50.34  ? 45  HIS U CG   1 
ATOM   237  N ND1  . HIS A 1 45  ? 106.688 131.081 145.476 1.00 51.39  ? 45  HIS U ND1  1 
ATOM   238  C CD2  . HIS A 1 45  ? 108.740 130.965 144.740 1.00 48.11  ? 45  HIS U CD2  1 
ATOM   239  C CE1  . HIS A 1 45  ? 107.145 129.880 145.778 1.00 47.67  ? 45  HIS U CE1  1 
ATOM   240  N NE2  . HIS A 1 45  ? 108.386 129.783 145.341 1.00 45.42  ? 45  HIS U NE2  1 
ATOM   241  N N    . GLU A 1 46  ? 109.923 134.974 145.283 1.00 43.55  ? 46  GLU U N    1 
ATOM   242  C CA   . GLU A 1 46  ? 111.308 135.060 145.744 1.00 39.64  ? 46  GLU U CA   1 
ATOM   243  C C    . GLU A 1 46  ? 111.381 135.740 147.108 1.00 38.22  ? 46  GLU U C    1 
ATOM   244  O O    . GLU A 1 46  ? 112.071 135.260 148.022 1.00 44.54  ? 46  GLU U O    1 
ATOM   245  C CB   . GLU A 1 46  ? 112.141 135.816 144.711 1.00 44.03  ? 46  GLU U CB   1 
ATOM   246  C CG   . GLU A 1 46  ? 113.635 135.582 144.796 1.00 46.51  ? 46  GLU U CG   1 
ATOM   247  C CD   . GLU A 1 46  ? 114.420 136.865 144.647 1.00 49.76  ? 46  GLU U CD   1 
ATOM   248  O OE1  . GLU A 1 46  ? 113.921 137.788 143.974 1.00 50.04  ? 46  GLU U OE1  1 
ATOM   249  O OE2  . GLU A 1 46  ? 115.543 136.951 145.183 1.00 49.20  ? 46  GLU U OE2  1 
ATOM   250  N N    . ARG A 1 47  ? 110.669 136.858 147.266 1.00 39.62  ? 47  ARG U N    1 
ATOM   251  C CA   . ARG A 1 47  ? 110.690 137.575 148.539 1.00 42.86  ? 47  ARG U CA   1 
ATOM   252  C C    . ARG A 1 47  ? 110.108 136.725 149.663 1.00 47.07  ? 47  ARG U C    1 
ATOM   253  O O    . ARG A 1 47  ? 110.644 136.703 150.783 1.00 51.96  ? 47  ARG U O    1 
ATOM   254  C CB   . ARG A 1 47  ? 109.936 138.899 148.420 1.00 44.75  ? 47  ARG U CB   1 
ATOM   255  C CG   . ARG A 1 47  ? 110.543 139.882 147.429 1.00 47.74  ? 47  ARG U CG   1 
ATOM   256  C CD   . ARG A 1 47  ? 111.112 141.099 148.148 1.00 50.82  ? 47  ARG U CD   1 
ATOM   257  N NE   . ARG A 1 47  ? 111.305 142.250 147.273 1.00 54.20  ? 47  ARG U NE   1 
ATOM   258  C CZ   . ARG A 1 47  ? 110.328 142.930 146.687 1.00 54.74  ? 47  ARG U CZ   1 
ATOM   259  N NH1  . ARG A 1 47  ? 109.056 142.617 146.870 1.00 51.45  ? 47  ARG U NH1  1 
ATOM   260  N NH2  . ARG A 1 47  ? 110.638 143.959 145.901 1.00 51.68  ? 47  ARG U NH2  1 
ATOM   261  N N    . GLN A 1 48  ? 109.005 136.024 149.390 1.00 48.63  ? 48  GLN U N    1 
ATOM   262  C CA   . GLN A 1 48  ? 108.396 135.181 150.417 1.00 48.10  ? 48  GLN U CA   1 
ATOM   263  C C    . GLN A 1 48  ? 109.340 134.062 150.843 1.00 49.22  ? 48  GLN U C    1 
ATOM   264  O O    . GLN A 1 48  ? 109.457 133.757 152.039 1.00 52.11  ? 48  GLN U O    1 
ATOM   265  C CB   . GLN A 1 48  ? 107.076 134.605 149.907 1.00 49.84  ? 48  GLN U CB   1 
ATOM   266  C CG   . GLN A 1 48  ? 106.011 134.443 150.978 1.00 52.81  ? 48  GLN U CG   1 
ATOM   267  C CD   . GLN A 1 48  ? 104.606 134.529 150.415 1.00 58.95  ? 48  GLN U CD   1 
ATOM   268  O OE1  . GLN A 1 48  ? 104.409 134.523 149.202 1.00 58.27  ? 48  GLN U OE1  1 
ATOM   269  N NE2  . GLN A 1 48  ? 103.619 134.605 151.302 1.00 56.91  ? 48  GLN U NE2  1 
ATOM   270  N N    . ALA A 1 49  ? 110.028 133.441 149.878 1.00 47.55  ? 49  ALA U N    1 
ATOM   271  C CA   . ALA A 1 49  ? 110.980 132.385 150.223 1.00 44.25  ? 49  ALA U CA   1 
ATOM   272  C C    . ALA A 1 49  ? 112.130 132.926 151.066 1.00 47.20  ? 49  ALA U C    1 
ATOM   273  O O    . ALA A 1 49  ? 112.567 132.273 152.025 1.00 48.07  ? 49  ALA U O    1 
ATOM   274  C CB   . ALA A 1 49  ? 111.507 131.727 148.950 1.00 43.75  ? 49  ALA U CB   1 
ATOM   275  N N    . LYS A 1 50  ? 112.634 134.116 150.728 1.00 47.15  ? 50  LYS U N    1 
ATOM   276  C CA   . LYS A 1 50  ? 113.708 134.702 151.526 1.00 42.90  ? 50  LYS U CA   1 
ATOM   277  C C    . LYS A 1 50  ? 113.255 134.971 152.954 1.00 44.41  ? 50  LYS U C    1 
ATOM   278  O O    . LYS A 1 50  ? 113.988 134.694 153.914 1.00 51.01  ? 50  LYS U O    1 
ATOM   279  C CB   . LYS A 1 50  ? 114.226 135.981 150.874 1.00 43.51  ? 50  LYS U CB   1 
ATOM   280  C CG   . LYS A 1 50  ? 115.177 135.744 149.717 1.00 43.69  ? 50  LYS U CG   1 
ATOM   281  C CD   . LYS A 1 50  ? 115.811 137.041 149.260 1.00 46.84  ? 50  LYS U CD   1 
ATOM   282  C CE   . LYS A 1 50  ? 116.723 136.829 148.067 1.00 47.21  ? 50  LYS U CE   1 
ATOM   283  N NZ   . LYS A 1 50  ? 116.967 135.389 147.787 1.00 46.36  ? 50  LYS U NZ   1 
ATOM   284  N N    . GLN A 1 51  ? 112.047 135.520 153.119 1.00 46.70  ? 51  GLN U N    1 
ATOM   285  C CA   . GLN A 1 51  ? 111.540 135.781 154.464 1.00 46.26  ? 51  GLN U CA   1 
ATOM   286  C C    . GLN A 1 51  ? 111.374 134.484 155.250 1.00 48.57  ? 51  GLN U C    1 
ATOM   287  O O    . GLN A 1 51  ? 111.683 134.424 156.448 1.00 52.46  ? 51  GLN U O    1 
ATOM   288  C CB   . GLN A 1 51  ? 110.218 136.541 154.389 1.00 48.71  ? 51  GLN U CB   1 
ATOM   289  C CG   . GLN A 1 51  ? 109.541 136.734 155.734 1.00 52.52  ? 51  GLN U CG   1 
ATOM   290  C CD   . GLN A 1 51  ? 108.165 137.345 155.611 1.00 56.98  ? 51  GLN U CD   1 
ATOM   291  O OE1  . GLN A 1 51  ? 107.678 137.590 154.507 1.00 57.60  ? 51  GLN U OE1  1 
ATOM   292  N NE2  . GLN A 1 51  ? 107.526 137.598 156.747 1.00 51.71  ? 51  GLN U NE2  1 
ATOM   293  N N    . ARG A 1 52  ? 110.887 133.429 154.587 1.00 50.07  ? 52  ARG U N    1 
ATOM   294  C CA   . ARG A 1 52  ? 110.728 132.143 155.257 1.00 48.15  ? 52  ARG U CA   1 
ATOM   295  C C    . ARG A 1 52  ? 112.070 131.596 155.731 1.00 49.05  ? 52  ARG U C    1 
ATOM   296  O O    . ARG A 1 52  ? 112.187 131.108 156.865 1.00 51.30  ? 52  ARG U O    1 
ATOM   297  C CB   . ARG A 1 52  ? 110.052 131.153 154.311 1.00 46.10  ? 52  ARG U CB   1 
ATOM   298  C CG   . ARG A 1 52  ? 109.829 129.769 154.885 1.00 45.65  ? 52  ARG U CG   1 
ATOM   299  C CD   . ARG A 1 52  ? 108.540 129.189 154.341 1.00 48.88  ? 52  ARG U CD   1 
ATOM   300  N NE   . ARG A 1 52  ? 108.617 129.014 152.895 1.00 53.75  ? 52  ARG U NE   1 
ATOM   301  C CZ   . ARG A 1 52  ? 107.722 129.476 152.034 1.00 53.83  ? 52  ARG U CZ   1 
ATOM   302  N NH1  . ARG A 1 52  ? 106.651 130.142 152.439 1.00 49.69  ? 52  ARG U NH1  1 
ATOM   303  N NH2  . ARG A 1 52  ? 107.905 129.268 150.734 1.00 50.93  ? 52  ARG U NH2  1 
ATOM   304  N N    . TRP A 1 53  ? 113.098 131.676 154.880 1.00 49.22  ? 53  TRP U N    1 
ATOM   305  C CA   . TRP A 1 53  ? 114.422 131.212 155.291 1.00 44.77  ? 53  TRP U CA   1 
ATOM   306  C C    . TRP A 1 53  ? 114.959 132.022 156.462 1.00 44.16  ? 53  TRP U C    1 
ATOM   307  O O    . TRP A 1 53  ? 115.564 131.464 157.386 1.00 48.79  ? 53  TRP U O    1 
ATOM   308  C CB   . TRP A 1 53  ? 115.411 131.265 154.129 1.00 44.94  ? 53  TRP U CB   1 
ATOM   309  C CG   . TRP A 1 53  ? 116.834 131.342 154.614 1.00 43.67  ? 53  TRP U CG   1 
ATOM   310  C CD1  . TRP A 1 53  ? 117.682 132.405 154.502 1.00 45.69  ? 53  TRP U CD1  1 
ATOM   311  C CD2  . TRP A 1 53  ? 117.549 130.335 155.345 1.00 44.32  ? 53  TRP U CD2  1 
ATOM   312  N NE1  . TRP A 1 53  ? 118.889 132.114 155.086 1.00 44.13  ? 53  TRP U NE1  1 
ATOM   313  C CE2  . TRP A 1 53  ? 118.834 130.851 155.616 1.00 43.61  ? 53  TRP U CE2  1 
ATOM   314  C CE3  . TRP A 1 53  ? 117.235 129.046 155.788 1.00 44.81  ? 53  TRP U CE3  1 
ATOM   315  C CZ2  . TRP A 1 53  ? 119.801 130.118 156.302 1.00 43.67  ? 53  TRP U CZ2  1 
ATOM   316  C CZ3  . TRP A 1 53  ? 118.195 128.323 156.469 1.00 43.82  ? 53  TRP U CZ3  1 
ATOM   317  C CH2  . TRP A 1 53  ? 119.462 128.861 156.721 1.00 40.37  ? 53  TRP U CH2  1 
ATOM   318  N N    . GLU A 1 54  ? 114.780 133.346 156.425 1.00 53.10  ? 54  GLU U N    1 
ATOM   319  C CA   . GLU A 1 54  ? 115.272 134.172 157.523 1.00 51.76  ? 54  GLU U CA   1 
ATOM   320  C C    . GLU A 1 54  ? 114.596 133.793 158.835 1.00 54.00  ? 54  GLU U C    1 
ATOM   321  O O    . GLU A 1 54  ? 115.252 133.686 159.878 1.00 54.94  ? 54  GLU U O    1 
ATOM   322  C CB   . GLU A 1 54  ? 115.052 135.651 157.209 1.00 52.29  ? 54  GLU U CB   1 
ATOM   323  C CG   . GLU A 1 54  ? 115.430 136.590 158.337 1.00 56.95  ? 54  GLU U CG   1 
ATOM   324  C CD   . GLU A 1 54  ? 116.930 136.702 158.529 1.00 63.52  ? 54  GLU U CD   1 
ATOM   325  O OE1  . GLU A 1 54  ? 117.681 136.346 157.595 1.00 63.07  ? 54  GLU U OE1  1 
ATOM   326  O OE2  . GLU A 1 54  ? 117.358 137.148 159.615 1.00 62.64  ? 54  GLU U OE2  1 
ATOM   327  N N    . GLU A 1 55  ? 113.280 133.565 158.794 1.00 60.04  ? 55  GLU U N    1 
ATOM   328  C CA   . GLU A 1 55  ? 112.570 133.160 160.002 1.00 57.96  ? 55  GLU U CA   1 
ATOM   329  C C    . GLU A 1 55  ? 113.060 131.808 160.509 1.00 59.18  ? 55  GLU U C    1 
ATOM   330  O O    . GLU A 1 55  ? 113.243 131.621 161.718 1.00 57.73  ? 55  GLU U O    1 
ATOM   331  C CB   . GLU A 1 55  ? 111.062 133.124 159.738 1.00 57.41  ? 55  GLU U CB   1 
ATOM   332  C CG   . GLU A 1 55  ? 110.244 132.575 160.894 1.00 62.32  ? 55  GLU U CG   1 
ATOM   333  C CD   . GLU A 1 55  ? 110.184 133.527 162.073 1.00 66.59  ? 55  GLU U CD   1 
ATOM   334  O OE1  . GLU A 1 55  ? 110.496 134.724 161.892 1.00 67.94  ? 55  GLU U OE1  1 
ATOM   335  O OE2  . GLU A 1 55  ? 109.826 133.078 163.181 1.00 65.29  ? 55  GLU U OE2  1 
ATOM   336  N N    . ARG A 1 56  ? 113.282 130.854 159.603 1.00 59.13  ? 56  ARG U N    1 
ATOM   337  C CA   . ARG A 1 56  ? 113.775 129.540 160.020 1.00 52.83  ? 56  ARG U CA   1 
ATOM   338  C C    . ARG A 1 56  ? 115.158 129.632 160.659 1.00 55.87  ? 56  ARG U C    1 
ATOM   339  O O    . ARG A 1 56  ? 115.421 128.989 161.686 1.00 56.88  ? 56  ARG U O    1 
ATOM   340  C CB   . ARG A 1 56  ? 113.795 128.586 158.825 1.00 49.27  ? 56  ARG U CB   1 
ATOM   341  C CG   . ARG A 1 56  ? 112.435 127.998 158.490 1.00 51.89  ? 56  ARG U CG   1 
ATOM   342  C CD   . ARG A 1 56  ? 112.470 127.238 157.180 1.00 53.42  ? 56  ARG U CD   1 
ATOM   343  N NE   . ARG A 1 56  ? 111.173 126.653 156.862 1.00 54.51  ? 56  ARG U NE   1 
ATOM   344  C CZ   . ARG A 1 56  ? 110.850 126.141 155.682 1.00 55.84  ? 56  ARG U CZ   1 
ATOM   345  N NH1  . ARG A 1 56  ? 111.709 126.135 154.675 1.00 54.50  ? 56  ARG U NH1  1 
ATOM   346  N NH2  . ARG A 1 56  ? 109.640 125.618 155.510 1.00 56.37  ? 56  ARG U NH2  1 
ATOM   347  N N    . LEU A 1 57  ? 116.056 130.423 160.065 1.00 55.00  ? 57  LEU U N    1 
ATOM   348  C CA   . LEU A 1 57  ? 117.388 130.590 160.642 1.00 52.31  ? 57  LEU U CA   1 
ATOM   349  C C    . LEU A 1 57  ? 117.316 131.231 162.023 1.00 56.24  ? 57  LEU U C    1 
ATOM   350  O O    . LEU A 1 57  ? 118.010 130.799 162.953 1.00 56.70  ? 57  LEU U O    1 
ATOM   351  C CB   . LEU A 1 57  ? 118.269 131.423 159.714 1.00 49.18  ? 57  LEU U CB   1 
ATOM   352  C CG   . LEU A 1 57  ? 119.728 131.569 160.155 1.00 51.00  ? 57  LEU U CG   1 
ATOM   353  C CD1  . LEU A 1 57  ? 120.549 130.355 159.764 1.00 54.74  ? 57  LEU U CD1  1 
ATOM   354  C CD2  . LEU A 1 57  ? 120.336 132.830 159.564 1.00 54.86  ? 57  LEU U CD2  1 
ATOM   355  N N    . ALA A 1 58  ? 116.482 132.263 162.174 1.00 63.53  ? 58  ALA U N    1 
ATOM   356  C CA   . ALA A 1 58  ? 116.350 132.911 163.474 1.00 63.07  ? 58  ALA U CA   1 
ATOM   357  C C    . ALA A 1 58  ? 115.799 131.944 164.514 1.00 64.02  ? 58  ALA U C    1 
ATOM   358  O O    . ALA A 1 58  ? 116.259 131.920 165.664 1.00 61.78  ? 58  ALA U O    1 
ATOM   359  C CB   . ALA A 1 58  ? 115.460 134.146 163.360 1.00 64.16  ? 58  ALA U CB   1 
ATOM   360  N N    . GLN A 1 59  ? 114.810 131.132 164.126 1.00 69.35  ? 59  GLN U N    1 
ATOM   361  C CA   . GLN A 1 59  ? 114.244 130.176 165.068 1.00 68.14  ? 59  GLN U CA   1 
ATOM   362  C C    . GLN A 1 59  ? 115.260 129.119 165.477 1.00 69.13  ? 59  GLN U C    1 
ATOM   363  O O    . GLN A 1 59  ? 115.326 128.753 166.651 1.00 69.42  ? 59  GLN U O    1 
ATOM   364  C CB   . GLN A 1 59  ? 113.000 129.522 164.470 1.00 69.06  ? 59  GLN U CB   1 
ATOM   365  C CG   . GLN A 1 59  ? 112.345 128.494 165.380 1.00 71.78  ? 59  GLN U CG   1 
ATOM   366  C CD   . GLN A 1 59  ? 111.961 129.069 166.730 1.00 75.31  ? 59  GLN U CD   1 
ATOM   367  O OE1  . GLN A 1 59  ? 111.536 130.218 166.831 1.00 72.53  ? 59  GLN U OE1  1 
ATOM   368  N NE2  . GLN A 1 59  ? 112.119 128.267 167.777 1.00 72.16  ? 59  GLN U NE2  1 
ATOM   369  N N    . PHE A 1 60  ? 116.081 128.633 164.538 1.00 67.72  ? 60  PHE U N    1 
ATOM   370  C CA   . PHE A 1 60  ? 117.102 127.661 164.930 1.00 65.65  ? 60  PHE U CA   1 
ATOM   371  C C    . PHE A 1 60  ? 118.106 128.296 165.884 1.00 64.44  ? 60  PHE U C    1 
ATOM   372  O O    . PHE A 1 60  ? 118.465 127.706 166.919 1.00 61.26  ? 60  PHE U O    1 
ATOM   373  C CB   . PHE A 1 60  ? 117.814 127.110 163.697 1.00 63.95  ? 60  PHE U CB   1 
ATOM   374  C CG   . PHE A 1 60  ? 118.755 125.976 163.997 1.00 63.08  ? 60  PHE U CG   1 
ATOM   375  C CD1  . PHE A 1 60  ? 118.276 124.686 164.153 1.00 62.12  ? 60  PHE U CD1  1 
ATOM   376  C CD2  . PHE A 1 60  ? 120.115 126.205 164.142 1.00 64.40  ? 60  PHE U CD2  1 
ATOM   377  C CE1  . PHE A 1 60  ? 119.140 123.643 164.428 1.00 58.76  ? 60  PHE U CE1  1 
ATOM   378  C CE2  . PHE A 1 60  ? 120.976 125.166 164.425 1.00 60.21  ? 60  PHE U CE2  1 
ATOM   379  C CZ   . PHE A 1 60  ? 120.490 123.884 164.569 1.00 56.89  ? 60  PHE U CZ   1 
ATOM   380  N N    . SER A 1 61  ? 118.552 129.515 165.553 1.00 72.84  ? 61  SER U N    1 
ATOM   381  C CA   . SER A 1 61  ? 119.552 130.196 166.365 1.00 71.15  ? 61  SER U CA   1 
ATOM   382  C C    . SER A 1 61  ? 119.055 130.337 167.795 1.00 72.53  ? 61  SER U C    1 
ATOM   383  O O    . SER A 1 61  ? 119.761 129.999 168.748 1.00 69.70  ? 61  SER U O    1 
ATOM   384  C CB   . SER A 1 61  ? 119.885 131.560 165.763 1.00 70.39  ? 61  SER U CB   1 
ATOM   385  O OG   . SER A 1 61  ? 120.884 132.220 166.521 1.00 72.26  ? 61  SER U OG   1 
ATOM   386  N N    . ARG A 1 62  ? 117.834 130.859 167.959 1.00 79.61  ? 62  ARG U N    1 
ATOM   387  C CA   . ARG A 1 62  ? 117.281 130.991 169.300 1.00 80.28  ? 62  ARG U CA   1 
ATOM   388  C C    . ARG A 1 62  ? 117.124 129.620 169.951 1.00 80.28  ? 62  ARG U C    1 
ATOM   389  O O    . ARG A 1 62  ? 117.422 129.450 171.140 1.00 81.36  ? 62  ARG U O    1 
ATOM   390  C CB   . ARG A 1 62  ? 115.942 131.724 169.240 1.00 82.81  ? 62  ARG U CB   1 
ATOM   391  C CG   . ARG A 1 62  ? 115.245 131.905 170.578 1.00 81.18  ? 62  ARG U CG   1 
ATOM   392  C CD   . ARG A 1 62  ? 113.842 132.447 170.363 1.00 81.38  ? 62  ARG U CD   1 
ATOM   393  N NE   . ARG A 1 62  ? 113.856 133.633 169.516 1.00 82.56  ? 62  ARG U NE   1 
ATOM   394  C CZ   . ARG A 1 62  ? 113.261 133.716 168.332 1.00 83.31  ? 62  ARG U CZ   1 
ATOM   395  N NH1  . ARG A 1 62  ? 112.624 132.682 167.805 1.00 82.94  ? 62  ARG U NH1  1 
ATOM   396  N NH2  . ARG A 1 62  ? 113.323 134.857 167.653 1.00 81.04  ? 62  ARG U NH2  1 
ATOM   397  N N    . GLY A 1 63  ? 116.627 128.639 169.186 1.00 77.12  ? 63  GLY U N    1 
ATOM   398  C CA   . GLY A 1 63  ? 116.405 127.304 169.714 1.00 77.19  ? 63  GLY U CA   1 
ATOM   399  C C    . GLY A 1 63  ? 117.610 126.730 170.429 1.00 77.92  ? 63  GLY U C    1 
ATOM   400  O O    . GLY A 1 63  ? 117.482 126.127 171.496 1.00 78.82  ? 63  GLY U O    1 
ATOM   401  N N    . HIS A 1 64  ? 118.801 126.910 169.854 1.00 74.96  ? 64  HIS U N    1 
ATOM   402  C CA   . HIS A 1 64  ? 119.998 126.299 170.431 1.00 75.74  ? 64  HIS U CA   1 
ATOM   403  C C    . HIS A 1 64  ? 121.092 127.294 170.796 1.00 74.36  ? 64  HIS U C    1 
ATOM   404  O O    . HIS A 1 64  ? 122.222 126.875 171.076 1.00 72.96  ? 64  HIS U O    1 
ATOM   405  C CB   . HIS A 1 64  ? 120.546 125.212 169.501 1.00 76.54  ? 64  HIS U CB   1 
ATOM   406  C CG   . HIS A 1 64  ? 119.497 124.279 168.984 1.00 76.27  ? 64  HIS U CG   1 
ATOM   407  N ND1  . HIS A 1 64  ? 119.211 124.140 167.643 1.00 75.00  ? 64  HIS U ND1  1 
ATOM   408  C CD2  . HIS A 1 64  ? 118.672 123.424 169.633 1.00 75.30  ? 64  HIS U CD2  1 
ATOM   409  C CE1  . HIS A 1 64  ? 118.250 123.247 167.490 1.00 72.86  ? 64  HIS U CE1  1 
ATOM   410  N NE2  . HIS A 1 64  ? 117.906 122.797 168.683 1.00 74.56  ? 64  HIS U NE2  1 
ATOM   411  N N    . GLN A 1 65  ? 120.791 128.593 170.812 1.00 79.27  ? 65  GLN U N    1 
ATOM   412  C CA   . GLN A 1 65  ? 121.705 129.638 171.274 1.00 80.32  ? 65  GLN U CA   1 
ATOM   413  C C    . GLN A 1 65  ? 123.052 129.648 170.556 1.00 78.41  ? 65  GLN U C    1 
ATOM   414  O O    . GLN A 1 65  ? 124.018 130.223 171.067 1.00 75.01  ? 65  GLN U O    1 
ATOM   415  C CB   . GLN A 1 65  ? 121.937 129.531 172.787 1.00 78.30  ? 65  GLN U CB   1 
ATOM   416  C CG   . GLN A 1 65  ? 120.666 129.507 173.619 1.00 78.74  ? 65  GLN U CG   1 
ATOM   417  C CD   . GLN A 1 65  ? 120.926 129.123 175.064 1.00 82.08  ? 65  GLN U CD   1 
ATOM   418  O OE1  . GLN A 1 65  ? 122.064 128.865 175.456 1.00 82.86  ? 65  GLN U OE1  1 
ATOM   419  N NE2  . GLN A 1 65  ? 119.868 129.097 175.867 1.00 80.86  ? 65  GLN U NE2  1 
ATOM   420  N N    . LEU A 1 66  ? 123.168 129.028 169.384 1.00 77.08  ? 66  LEU U N    1 
ATOM   421  C CA   . LEU A 1 66  ? 124.414 129.141 168.640 1.00 75.41  ? 66  LEU U CA   1 
ATOM   422  C C    . LEU A 1 66  ? 124.574 130.552 168.082 1.00 74.96  ? 66  LEU U C    1 
ATOM   423  O O    . LEU A 1 66  ? 123.603 131.213 167.711 1.00 73.64  ? 66  LEU U O    1 
ATOM   424  C CB   . LEU A 1 66  ? 124.470 128.125 167.500 1.00 72.28  ? 66  LEU U CB   1 
ATOM   425  C CG   . LEU A 1 66  ? 124.308 126.647 167.849 1.00 73.74  ? 66  LEU U CG   1 
ATOM   426  C CD1  . LEU A 1 66  ? 123.053 126.095 167.206 1.00 74.31  ? 66  LEU U CD1  1 
ATOM   427  C CD2  . LEU A 1 66  ? 125.526 125.855 167.417 1.00 74.77  ? 66  LEU U CD2  1 
ATOM   428  N N    . SER A 1 67  ? 125.829 131.011 168.033 1.00 77.06  ? 67  SER U N    1 
ATOM   429  C CA   . SER A 1 67  ? 126.119 132.368 167.501 1.00 74.07  ? 67  SER U CA   1 
ATOM   430  C C    . SER A 1 67  ? 125.979 132.362 165.976 1.00 77.21  ? 67  SER U C    1 
ATOM   431  O O    . SER A 1 67  ? 126.153 131.287 165.368 1.00 79.26  ? 67  SER U O    1 
ATOM   432  C CB   . SER A 1 67  ? 127.491 132.829 167.916 1.00 74.55  ? 67  SER U CB   1 
ATOM   433  O OG   . SER A 1 67  ? 128.495 131.997 167.353 1.00 76.45  ? 67  SER U OG   1 
ATOM   434  N N    . ARG A 1 68  ? 125.689 133.523 165.390 1.00 75.90  ? 68  ARG U N    1 
ATOM   435  C CA   . ARG A 1 68  ? 125.499 133.602 163.920 1.00 75.24  ? 68  ARG U CA   1 
ATOM   436  C C    . ARG A 1 68  ? 126.800 133.210 163.216 1.00 75.70  ? 68  ARG U C    1 
ATOM   437  O O    . ARG A 1 68  ? 126.724 132.434 162.247 1.00 76.76  ? 68  ARG U O    1 
ATOM   438  C CB   . ARG A 1 68  ? 125.058 135.012 163.517 1.00 75.09  ? 68  ARG U CB   1 
ATOM   439  C CG   . ARG A 1 68  ? 123.951 135.584 164.391 1.00 75.32  ? 68  ARG U CG   1 
ATOM   440  C CD   . ARG A 1 68  ? 122.585 135.019 164.051 1.00 74.22  ? 68  ARG U CD   1 
ATOM   441  N NE   . ARG A 1 68  ? 121.531 136.012 164.205 1.00 74.73  ? 68  ARG U NE   1 
ATOM   442  C CZ   . ARG A 1 68  ? 120.258 135.818 163.880 1.00 75.12  ? 68  ARG U CZ   1 
ATOM   443  N NH1  . ARG A 1 68  ? 119.368 136.772 164.088 1.00 73.75  ? 68  ARG U NH1  1 
ATOM   444  N NH2  . ARG A 1 68  ? 119.878 134.667 163.351 1.00 73.28  ? 68  ARG U NH2  1 
ATOM   445  N N    . ASP A 1 69  ? 127.949 133.701 163.694 1.00 74.59  ? 69  ASP U N    1 
ATOM   446  C CA   . ASP A 1 69  ? 129.185 133.428 162.965 1.00 74.99  ? 69  ASP U CA   1 
ATOM   447  C C    . ASP A 1 69  ? 129.473 131.934 162.902 1.00 76.42  ? 69  ASP U C    1 
ATOM   448  O O    . ASP A 1 69  ? 129.985 131.433 161.894 1.00 77.50  ? 69  ASP U O    1 
ATOM   449  C CB   . ASP A 1 69  ? 130.352 134.176 163.608 1.00 76.49  ? 69  ASP U CB   1 
ATOM   450  C CG   . ASP A 1 69  ? 130.167 135.681 163.573 1.00 79.52  ? 69  ASP U CG   1 
ATOM   451  O OD1  . ASP A 1 69  ? 129.488 136.176 162.650 1.00 79.26  ? 69  ASP U OD1  1 
ATOM   452  O OD2  . ASP A 1 69  ? 130.705 136.366 164.471 1.00 79.07  ? 69  ASP U OD2  1 
ATOM   453  N N    . GLU A 1 70  ? 129.169 131.211 163.983 1.00 69.06  ? 70  GLU U N    1 
ATOM   454  C CA   . GLU A 1 70  ? 129.395 129.771 163.987 1.00 67.97  ? 70  GLU U CA   1 
ATOM   455  C C    . GLU A 1 70  ? 128.525 129.095 162.936 1.00 69.75  ? 70  GLU U C    1 
ATOM   456  O O    . GLU A 1 70  ? 128.982 128.196 162.217 1.00 70.77  ? 70  GLU U O    1 
ATOM   457  C CB   . GLU A 1 70  ? 129.108 129.199 165.373 1.00 67.71  ? 70  GLU U CB   1 
ATOM   458  C CG   . GLU A 1 70  ? 129.805 129.938 166.500 1.00 69.99  ? 70  GLU U CG   1 
ATOM   459  C CD   . GLU A 1 70  ? 129.475 129.366 167.863 1.00 72.77  ? 70  GLU U CD   1 
ATOM   460  O OE1  . GLU A 1 70  ? 128.836 128.294 167.919 1.00 75.93  ? 70  GLU U OE1  1 
ATOM   461  O OE2  . GLU A 1 70  ? 129.859 129.984 168.878 1.00 72.13  ? 70  GLU U OE2  1 
ATOM   462  N N    . LEU A 1 71  ? 127.267 129.521 162.831 1.00 62.11  ? 71  LEU U N    1 
ATOM   463  C CA   . LEU A 1 71  ? 126.381 128.978 161.810 1.00 60.15  ? 71  LEU U CA   1 
ATOM   464  C C    . LEU A 1 71  ? 126.872 129.336 160.414 1.00 58.14  ? 71  LEU U C    1 
ATOM   465  O O    . LEU A 1 71  ? 126.774 128.520 159.491 1.00 60.17  ? 71  LEU U O    1 
ATOM   466  C CB   . LEU A 1 71  ? 124.957 129.486 162.030 1.00 60.83  ? 71  LEU U CB   1 
ATOM   467  C CG   . LEU A 1 71  ? 124.146 128.768 163.112 1.00 61.86  ? 71  LEU U CG   1 
ATOM   468  C CD1  . LEU A 1 71  ? 122.669 129.095 162.985 1.00 62.08  ? 71  LEU U CD1  1 
ATOM   469  C CD2  . LEU A 1 71  ? 124.370 127.265 163.051 1.00 60.31  ? 71  LEU U CD2  1 
ATOM   470  N N    . ARG A 1 72  ? 127.412 130.547 160.240 1.00 57.74  ? 72  ARG U N    1 
ATOM   471  C CA   . ARG A 1 72  ? 127.964 130.912 158.937 1.00 59.25  ? 72  ARG U CA   1 
ATOM   472  C C    . ARG A 1 72  ? 129.145 130.022 158.561 1.00 61.35  ? 72  ARG U C    1 
ATOM   473  O O    . ARG A 1 72  ? 129.258 129.580 157.409 1.00 61.25  ? 72  ARG U O    1 
ATOM   474  C CB   . ARG A 1 72  ? 128.389 132.381 158.949 1.00 60.74  ? 72  ARG U CB   1 
ATOM   475  C CG   . ARG A 1 72  ? 127.252 133.361 159.166 1.00 65.34  ? 72  ARG U CG   1 
ATOM   476  C CD   . ARG A 1 72  ? 126.520 133.666 157.871 1.00 66.14  ? 72  ARG U CD   1 
ATOM   477  N NE   . ARG A 1 72  ? 127.412 134.242 156.872 1.00 67.11  ? 72  ARG U NE   1 
ATOM   478  C CZ   . ARG A 1 72  ? 127.820 135.504 156.874 1.00 66.25  ? 72  ARG U CZ   1 
ATOM   479  N NH1  . ARG A 1 72  ? 127.425 136.356 157.805 1.00 63.31  ? 72  ARG U NH1  1 
ATOM   480  N NH2  . ARG A 1 72  ? 128.645 135.920 155.918 1.00 65.91  ? 72  ARG U NH2  1 
ATOM   481  N N    . GLY A 1 73  ? 130.033 129.747 159.517 1.00 56.03  ? 73  GLY U N    1 
ATOM   482  C CA   . GLY A 1 73  ? 131.145 128.844 159.248 1.00 53.06  ? 73  GLY U CA   1 
ATOM   483  C C    . GLY A 1 73  ? 130.695 127.431 158.926 1.00 53.27  ? 73  GLY U C    1 
ATOM   484  O O    . GLY A 1 73  ? 131.210 126.795 158.000 1.00 53.76  ? 73  GLY U O    1 
ATOM   485  N N    . PHE A 1 74  ? 129.719 126.928 159.687 1.00 46.72  ? 74  PHE U N    1 
ATOM   486  C CA   . PHE A 1 74  ? 129.173 125.599 159.426 1.00 40.95  ? 74  PHE U CA   1 
ATOM   487  C C    . PHE A 1 74  ? 128.554 125.531 158.034 1.00 44.45  ? 74  PHE U C    1 
ATOM   488  O O    . PHE A 1 74  ? 128.745 124.547 157.309 1.00 41.61  ? 74  PHE U O    1 
ATOM   489  C CB   . PHE A 1 74  ? 128.153 125.238 160.507 1.00 38.51  ? 74  PHE U CB   1 
ATOM   490  C CG   . PHE A 1 74  ? 127.659 123.822 160.434 1.00 42.11  ? 74  PHE U CG   1 
ATOM   491  C CD1  . PHE A 1 74  ? 128.527 122.763 160.652 1.00 41.08  ? 74  PHE U CD1  1 
ATOM   492  C CD2  . PHE A 1 74  ? 126.327 123.546 160.169 1.00 42.01  ? 74  PHE U CD2  1 
ATOM   493  C CE1  . PHE A 1 74  ? 128.079 121.460 160.593 1.00 40.75  ? 74  PHE U CE1  1 
ATOM   494  C CE2  . PHE A 1 74  ? 125.875 122.244 160.109 1.00 41.55  ? 74  PHE U CE2  1 
ATOM   495  C CZ   . PHE A 1 74  ? 126.750 121.200 160.323 1.00 40.93  ? 74  PHE U CZ   1 
ATOM   496  N N    . LEU A 1 75  ? 127.817 126.568 157.639 1.00 46.15  ? 75  LEU U N    1 
ATOM   497  C CA   . LEU A 1 75  ? 127.190 126.572 156.323 1.00 42.07  ? 75  LEU U CA   1 
ATOM   498  C C    . LEU A 1 75  ? 128.220 126.699 155.208 1.00 45.29  ? 75  LEU U C    1 
ATOM   499  O O    . LEU A 1 75  ? 128.029 126.136 154.127 1.00 44.33  ? 75  LEU U O    1 
ATOM   500  C CB   . LEU A 1 75  ? 126.161 127.696 156.232 1.00 40.91  ? 75  LEU U CB   1 
ATOM   501  C CG   . LEU A 1 75  ? 124.905 127.519 157.088 1.00 38.22  ? 75  LEU U CG   1 
ATOM   502  C CD1  . LEU A 1 75  ? 123.975 128.711 156.947 1.00 39.45  ? 75  LEU U CD1  1 
ATOM   503  C CD2  . LEU A 1 75  ? 124.189 126.230 156.733 1.00 39.50  ? 75  LEU U CD2  1 
ATOM   504  N N    . ARG A 1 76  ? 129.314 127.427 155.444 1.00 46.27  ? 76  ARG U N    1 
ATOM   505  C CA   . ARG A 1 76  ? 130.386 127.480 154.452 1.00 41.79  ? 76  ARG U CA   1 
ATOM   506  C C    . ARG A 1 76  ? 131.028 126.109 154.266 1.00 44.65  ? 76  ARG U C    1 
ATOM   507  O O    . ARG A 1 76  ? 131.290 125.678 153.132 1.00 42.04  ? 76  ARG U O    1 
ATOM   508  C CB   . ARG A 1 76  ? 131.432 128.509 154.876 1.00 40.80  ? 76  ARG U CB   1 
ATOM   509  C CG   . ARG A 1 76  ? 132.288 129.050 153.744 1.00 47.87  ? 76  ARG U CG   1 
ATOM   510  C CD   . ARG A 1 76  ? 133.391 129.951 154.278 1.00 48.26  ? 76  ARG U CD   1 
ATOM   511  N NE   . ARG A 1 76  ? 132.884 130.961 155.196 1.00 46.65  ? 76  ARG U NE   1 
ATOM   512  C CZ   . ARG A 1 76  ? 132.446 132.157 154.828 1.00 48.18  ? 76  ARG U CZ   1 
ATOM   513  N NH1  . ARG A 1 76  ? 132.433 132.528 153.557 1.00 45.12  ? 76  ARG U NH1  1 
ATOM   514  N NH2  . ARG A 1 76  ? 132.005 133.002 155.755 1.00 47.53  ? 76  ARG U NH2  1 
ATOM   515  N N    . HIS A 1 77  ? 131.278 125.401 155.373 1.00 44.46  ? 77  HIS U N    1 
ATOM   516  C CA   . HIS A 1 77  ? 131.785 124.034 155.277 1.00 36.51  ? 77  HIS U CA   1 
ATOM   517  C C    . HIS A 1 77  ? 130.806 123.130 154.539 1.00 39.51  ? 77  HIS U C    1 
ATOM   518  O O    . HIS A 1 77  ? 131.214 122.291 153.723 1.00 40.49  ? 77  HIS U O    1 
ATOM   519  C CB   . HIS A 1 77  ? 132.087 123.479 156.667 1.00 37.39  ? 77  HIS U CB   1 
ATOM   520  C CG   . HIS A 1 77  ? 133.375 123.975 157.246 1.00 41.03  ? 77  HIS U CG   1 
ATOM   521  N ND1  . HIS A 1 77  ? 133.815 123.617 158.501 1.00 41.29  ? 77  HIS U ND1  1 
ATOM   522  C CD2  . HIS A 1 77  ? 134.328 124.786 156.730 1.00 41.83  ? 77  HIS U CD2  1 
ATOM   523  C CE1  . HIS A 1 77  ? 134.975 124.198 158.739 1.00 39.98  ? 77  HIS U CE1  1 
ATOM   524  N NE2  . HIS A 1 77  ? 135.309 124.914 157.681 1.00 43.22  ? 77  HIS U NE2  1 
ATOM   525  N N    . TYR A 1 78  ? 129.507 123.281 154.810 1.00 43.16  ? 78  TYR U N    1 
ATOM   526  C CA   . TYR A 1 78  ? 128.515 122.450 154.139 1.00 36.94  ? 78  TYR U CA   1 
ATOM   527  C C    . TYR A 1 78  ? 128.462 122.753 152.648 1.00 37.29  ? 78  TYR U C    1 
ATOM   528  O O    . TYR A 1 78  ? 128.258 121.848 151.836 1.00 49.40  ? 78  TYR U O    1 
ATOM   529  C CB   . TYR A 1 78  ? 127.138 122.645 154.769 1.00 42.04  ? 78  TYR U CB   1 
ATOM   530  C CG   . TYR A 1 78  ? 126.088 121.735 154.173 1.00 41.41  ? 78  TYR U CG   1 
ATOM   531  C CD1  . TYR A 1 78  ? 126.250 120.355 154.202 1.00 39.46  ? 78  TYR U CD1  1 
ATOM   532  C CD2  . TYR A 1 78  ? 124.952 122.247 153.563 1.00 38.27  ? 78  TYR U CD2  1 
ATOM   533  C CE1  . TYR A 1 78  ? 125.303 119.514 153.657 1.00 35.55  ? 78  TYR U CE1  1 
ATOM   534  C CE2  . TYR A 1 78  ? 123.999 121.414 153.012 1.00 42.09  ? 78  TYR U CE2  1 
ATOM   535  C CZ   . TYR A 1 78  ? 124.180 120.047 153.063 1.00 41.59  ? 78  TYR U CZ   1 
ATOM   536  O OH   . TYR A 1 78  ? 123.237 119.208 152.518 1.00 45.65  ? 78  TYR U OH   1 
ATOM   537  N N    . GLU A 1 79  ? 128.618 124.024 152.272 1.00 38.18  ? 79  GLU U N    1 
ATOM   538  C CA   . GLU A 1 79  ? 128.674 124.377 150.856 1.00 41.00  ? 79  GLU U CA   1 
ATOM   539  C C    . GLU A 1 79  ? 129.882 123.741 150.182 1.00 45.92  ? 79  GLU U C    1 
ATOM   540  O O    . GLU A 1 79  ? 129.781 123.220 149.062 1.00 48.47  ? 79  GLU U O    1 
ATOM   541  C CB   . GLU A 1 79  ? 128.704 125.896 150.690 1.00 43.38  ? 79  GLU U CB   1 
ATOM   542  C CG   . GLU A 1 79  ? 127.335 126.539 150.605 1.00 48.93  ? 79  GLU U CG   1 
ATOM   543  C CD   . GLU A 1 79  ? 127.404 128.011 150.258 1.00 50.98  ? 79  GLU U CD   1 
ATOM   544  O OE1  . GLU A 1 79  ? 128.423 128.440 149.674 1.00 49.83  ? 79  GLU U OE1  1 
ATOM   545  O OE2  . GLU A 1 79  ? 126.437 128.743 150.556 1.00 52.54  ? 79  GLU U OE2  1 
ATOM   546  N N    . GLU A 1 80  ? 131.037 123.779 150.853 1.00 47.52  ? 80  GLU U N    1 
ATOM   547  C CA   . GLU A 1 80  ? 132.219 123.122 150.307 1.00 42.25  ? 80  GLU U CA   1 
ATOM   548  C C    . GLU A 1 80  ? 131.988 121.624 150.134 1.00 41.48  ? 80  GLU U C    1 
ATOM   549  O O    . GLU A 1 80  ? 132.385 121.038 149.120 1.00 40.33  ? 80  GLU U O    1 
ATOM   550  C CB   . GLU A 1 80  ? 133.422 123.380 151.214 1.00 42.26  ? 80  GLU U CB   1 
ATOM   551  C CG   . GLU A 1 80  ? 134.679 122.629 150.809 1.00 43.76  ? 80  GLU U CG   1 
ATOM   552  C CD   . GLU A 1 80  ? 135.880 123.005 151.654 1.00 52.48  ? 80  GLU U CD   1 
ATOM   553  O OE1  . GLU A 1 80  ? 135.782 123.986 152.423 1.00 52.60  ? 80  GLU U OE1  1 
ATOM   554  O OE2  . GLU A 1 80  ? 136.918 122.325 151.549 1.00 54.36  ? 80  GLU U OE2  1 
ATOM   555  N N    . ALA A 1 81  ? 131.337 120.988 151.112 1.00 43.61  ? 81  ALA U N    1 
ATOM   556  C CA   . ALA A 1 81  ? 131.036 119.562 151.001 1.00 39.40  ? 81  ALA U CA   1 
ATOM   557  C C    . ALA A 1 81  ? 130.068 119.281 149.856 1.00 38.14  ? 81  ALA U C    1 
ATOM   558  O O    . ALA A 1 81  ? 130.240 118.311 149.109 1.00 43.32  ? 81  ALA U O    1 
ATOM   559  C CB   . ALA A 1 81  ? 130.463 119.041 152.316 1.00 35.17  ? 81  ALA U CB   1 
ATOM   560  N N    . THR A 1 82  ? 129.040 120.120 149.713 1.00 41.39  ? 82  THR U N    1 
ATOM   561  C CA   . THR A 1 82  ? 128.055 119.945 148.653 1.00 40.93  ? 82  THR U CA   1 
ATOM   562  C C    . THR A 1 82  ? 128.696 120.082 147.280 1.00 43.17  ? 82  THR U C    1 
ATOM   563  O O    . THR A 1 82  ? 128.311 119.382 146.338 1.00 41.05  ? 82  THR U O    1 
ATOM   564  C CB   . THR A 1 82  ? 126.920 120.959 148.830 1.00 40.54  ? 82  THR U CB   1 
ATOM   565  O OG1  . THR A 1 82  ? 126.126 120.596 149.966 1.00 40.35  ? 82  THR U OG1  1 
ATOM   566  C CG2  . THR A 1 82  ? 126.031 121.010 147.601 1.00 48.00  ? 82  THR U CG2  1 
ATOM   567  N N    . ARG A 1 83  ? 129.696 120.956 147.160 1.00 49.88  ? 83  ARG U N    1 
ATOM   568  C CA   . ARG A 1 83  ? 130.440 121.072 145.913 1.00 42.82  ? 83  ARG U CA   1 
ATOM   569  C C    . ARG A 1 83  ? 131.144 119.777 145.525 1.00 44.01  ? 83  ARG U C    1 
ATOM   570  O O    . ARG A 1 83  ? 131.506 119.610 144.355 1.00 52.86  ? 83  ARG U O    1 
ATOM   571  C CB   . ARG A 1 83  ? 131.464 122.207 146.020 1.00 46.15  ? 83  ARG U CB   1 
ATOM   572  C CG   . ARG A 1 83  ? 131.461 123.158 144.836 1.00 48.75  ? 83  ARG U CG   1 
ATOM   573  C CD   . ARG A 1 83  ? 131.747 124.587 145.274 1.00 52.47  ? 83  ARG U CD   1 
ATOM   574  N NE   . ARG A 1 83  ? 132.877 124.665 146.190 1.00 55.58  ? 83  ARG U NE   1 
ATOM   575  C CZ   . ARG A 1 83  ? 133.011 125.577 147.144 1.00 54.29  ? 83  ARG U CZ   1 
ATOM   576  N NH1  . ARG A 1 83  ? 132.090 126.505 147.345 1.00 50.19  ? 83  ARG U NH1  1 
ATOM   577  N NH2  . ARG A 1 83  ? 134.092 125.555 147.919 1.00 52.03  ? 83  ARG U NH2  1 
ATOM   578  N N    . ALA A 1 84  ? 131.344 118.854 146.466 1.00 41.89  ? 84  ALA U N    1 
ATOM   579  C CA   . ALA A 1 84  ? 131.999 117.585 146.179 1.00 37.35  ? 84  ALA U CA   1 
ATOM   580  C C    . ALA A 1 84  ? 131.035 116.418 145.990 1.00 40.13  ? 84  ALA U C    1 
ATOM   581  O O    . ALA A 1 84  ? 131.495 115.297 145.756 1.00 43.93  ? 84  ALA U O    1 
ATOM   582  C CB   . ALA A 1 84  ? 132.996 117.248 147.290 1.00 39.35  ? 84  ALA U CB   1 
ATOM   583  N N    . GLY A 1 85  ? 129.725 116.640 146.087 1.00 42.48  ? 85  GLY U N    1 
ATOM   584  C CA   . GLY A 1 85  ? 128.753 115.593 145.838 1.00 40.59  ? 85  GLY U CA   1 
ATOM   585  C C    . GLY A 1 85  ? 127.921 115.168 147.031 1.00 43.07  ? 85  GLY U C    1 
ATOM   586  O O    . GLY A 1 85  ? 126.999 114.362 146.855 1.00 51.03  ? 85  GLY U O    1 
ATOM   587  N N    . ILE A 1 86  ? 128.208 115.669 148.231 1.00 40.27  ? 86  ILE U N    1 
ATOM   588  C CA   . ILE A 1 86  ? 127.452 115.262 149.409 1.00 34.34  ? 86  ILE U CA   1 
ATOM   589  C C    . ILE A 1 86  ? 126.060 115.878 149.373 1.00 38.42  ? 86  ILE U C    1 
ATOM   590  O O    . ILE A 1 86  ? 125.891 117.067 149.071 1.00 43.56  ? 86  ILE U O    1 
ATOM   591  C CB   . ILE A 1 86  ? 128.210 115.661 150.689 1.00 38.97  ? 86  ILE U CB   1 
ATOM   592  C CG1  . ILE A 1 86  ? 129.509 114.857 150.806 1.00 38.82  ? 86  ILE U CG1  1 
ATOM   593  C CG2  . ILE A 1 86  ? 127.333 115.485 151.923 1.00 39.05  ? 86  ILE U CG2  1 
ATOM   594  C CD1  . ILE A 1 86  ? 129.369 113.556 151.572 1.00 39.65  ? 86  ILE U CD1  1 
ATOM   595  N N    . ARG A 1 87  ? 125.048 115.066 149.678 1.00 47.26  ? 87  ARG U N    1 
ATOM   596  C CA   . ARG A 1 87  ? 123.673 115.538 149.760 1.00 48.08  ? 87  ARG U CA   1 
ATOM   597  C C    . ARG A 1 87  ? 123.012 114.946 150.998 1.00 48.84  ? 87  ARG U C    1 
ATOM   598  O O    . ARG A 1 87  ? 123.479 113.955 151.564 1.00 52.63  ? 87  ARG U O    1 
ATOM   599  C CB   . ARG A 1 87  ? 122.867 115.168 148.507 1.00 46.28  ? 87  ARG U CB   1 
ATOM   600  C CG   . ARG A 1 87  ? 123.356 115.838 147.233 1.00 46.05  ? 87  ARG U CG   1 
ATOM   601  C CD   . ARG A 1 87  ? 122.613 117.136 146.963 1.00 47.86  ? 87  ARG U CD   1 
ATOM   602  N NE   . ARG A 1 87  ? 122.786 117.622 145.598 1.00 52.95  ? 87  ARG U NE   1 
ATOM   603  C CZ   . ARG A 1 87  ? 123.951 117.937 145.042 1.00 53.81  ? 87  ARG U CZ   1 
ATOM   604  N NH1  . ARG A 1 87  ? 125.085 117.877 145.719 1.00 47.38  ? 87  ARG U NH1  1 
ATOM   605  N NH2  . ARG A 1 87  ? 123.975 118.340 143.774 1.00 54.90  ? 87  ARG U NH2  1 
ATOM   606  N N    . VAL A 1 88  ? 121.917 115.581 151.420 1.00 55.37  ? 88  VAL U N    1 
ATOM   607  C CA   . VAL A 1 88  ? 121.211 115.127 152.615 1.00 56.18  ? 88  VAL U CA   1 
ATOM   608  C C    . VAL A 1 88  ? 120.528 113.781 152.384 1.00 57.51  ? 88  VAL U C    1 
ATOM   609  O O    . VAL A 1 88  ? 120.356 113.000 153.328 1.00 54.82  ? 88  VAL U O    1 
ATOM   610  C CB   . VAL A 1 88  ? 120.217 116.207 153.086 1.00 52.97  ? 88  VAL U CB   1 
ATOM   611  C CG1  . VAL A 1 88  ? 118.880 116.088 152.365 1.00 52.02  ? 88  VAL U CG1  1 
ATOM   612  C CG2  . VAL A 1 88  ? 120.022 116.130 154.590 1.00 51.54  ? 88  VAL U CG2  1 
ATOM   613  N N    . ASP A 1 89  ? 120.137 113.482 151.150 1.00 58.14  ? 89  ASP U N    1 
ATOM   614  C CA   . ASP A 1 89  ? 119.580 112.186 150.796 1.00 56.69  ? 89  ASP U CA   1 
ATOM   615  C C    . ASP A 1 89  ? 120.660 111.272 150.228 1.00 60.16  ? 89  ASP U C    1 
ATOM   616  O O    . ASP A 1 89  ? 121.758 111.705 149.873 1.00 64.96  ? 89  ASP U O    1 
ATOM   617  C CB   . ASP A 1 89  ? 118.432 112.348 149.793 1.00 57.13  ? 89  ASP U CB   1 
ATOM   618  C CG   . ASP A 1 89  ? 117.192 112.959 150.418 1.00 64.20  ? 89  ASP U CG   1 
ATOM   619  O OD1  . ASP A 1 89  ? 116.978 112.764 151.635 1.00 63.97  ? 89  ASP U OD1  1 
ATOM   620  O OD2  . ASP A 1 89  ? 116.430 113.632 149.692 1.00 66.61  ? 89  ASP U OD2  1 
ATOM   621  N N    . ASN A 1 90  ? 120.333 109.984 150.147 1.00 57.60  ? 90  ASN U N    1 
ATOM   622  C CA   . ASN A 1 90  ? 121.270 109.004 149.615 1.00 54.35  ? 90  ASN U CA   1 
ATOM   623  C C    . ASN A 1 90  ? 121.373 109.153 148.104 1.00 53.43  ? 90  ASN U C    1 
ATOM   624  O O    . ASN A 1 90  ? 120.364 109.064 147.395 1.00 57.20  ? 90  ASN U O    1 
ATOM   625  C CB   . ASN A 1 90  ? 120.825 107.590 149.984 1.00 58.23  ? 90  ASN U CB   1 
ATOM   626  C CG   . ASN A 1 90  ? 120.695 107.392 151.479 1.00 60.95  ? 90  ASN U CG   1 
ATOM   627  O OD1  . ASN A 1 90  ? 120.703 108.354 152.248 1.00 62.03  ? 90  ASN U OD1  1 
ATOM   628  N ND2  . ASN A 1 90  ? 120.566 106.140 151.900 1.00 58.04  ? 90  ASN U ND2  1 
ATOM   629  N N    . VAL A 1 91  ? 122.590 109.368 147.605 1.00 40.53  ? 91  VAL U N    1 
ATOM   630  C CA   . VAL A 1 91  ? 122.832 109.531 146.181 1.00 40.05  ? 91  VAL U CA   1 
ATOM   631  C C    . VAL A 1 91  ? 123.960 108.599 145.761 1.00 36.80  ? 91  VAL U C    1 
ATOM   632  O O    . VAL A 1 91  ? 124.783 108.171 146.571 1.00 37.95  ? 91  VAL U O    1 
ATOM   633  C CB   . VAL A 1 91  ? 123.165 110.989 145.796 1.00 38.35  ? 91  VAL U CB   1 
ATOM   634  C CG1  . VAL A 1 91  ? 121.978 111.899 146.073 1.00 40.14  ? 91  VAL U CG1  1 
ATOM   635  C CG2  . VAL A 1 91  ? 124.393 111.472 146.549 1.00 41.74  ? 91  VAL U CG2  1 
ATOM   636  N N    . ARG A 1 92  ? 123.978 108.283 144.470 1.00 35.00  ? 92  ARG U N    1 
ATOM   637  C CA   . ARG A 1 92  ? 124.980 107.385 143.926 1.00 30.75  ? 92  ARG U CA   1 
ATOM   638  C C    . ARG A 1 92  ? 126.368 108.027 143.984 1.00 38.89  ? 92  ARG U C    1 
ATOM   639  O O    . ARG A 1 92  ? 126.495 109.254 143.940 1.00 47.06  ? 92  ARG U O    1 
ATOM   640  C CB   . ARG A 1 92  ? 124.620 107.015 142.489 1.00 31.55  ? 92  ARG U CB   1 
ATOM   641  C CG   . ARG A 1 92  ? 124.656 108.184 141.517 1.00 34.04  ? 92  ARG U CG   1 
ATOM   642  C CD   . ARG A 1 92  ? 124.066 107.805 140.173 1.00 35.87  ? 92  ARG U CD   1 
ATOM   643  N NE   . ARG A 1 92  ? 124.870 106.808 139.479 1.00 40.18  ? 92  ARG U NE   1 
ATOM   644  C CZ   . ARG A 1 92  ? 124.672 106.429 138.224 1.00 36.22  ? 92  ARG U CZ   1 
ATOM   645  N NH1  . ARG A 1 92  ? 123.704 106.953 137.488 1.00 31.46  ? 92  ARG U NH1  1 
ATOM   646  N NH2  . ARG A 1 92  ? 125.469 105.507 137.692 1.00 36.48  ? 92  ARG U NH2  1 
ATOM   647  N N    . PRO A 1 93  ? 127.421 107.219 144.098 1.00 34.48  ? 93  PRO U N    1 
ATOM   648  C CA   . PRO A 1 93  ? 128.778 107.776 144.116 1.00 27.30  ? 93  PRO U CA   1 
ATOM   649  C C    . PRO A 1 93  ? 129.169 108.385 142.778 1.00 29.33  ? 93  PRO U C    1 
ATOM   650  O O    . PRO A 1 93  ? 128.655 108.012 141.721 1.00 40.19  ? 93  PRO U O    1 
ATOM   651  C CB   . PRO A 1 93  ? 129.655 106.567 144.452 1.00 26.21  ? 93  PRO U CB   1 
ATOM   652  C CG   . PRO A 1 93  ? 128.847 105.384 144.037 1.00 31.50  ? 93  PRO U CG   1 
ATOM   653  C CD   . PRO A 1 93  ? 127.419 105.760 144.293 1.00 34.44  ? 93  PRO U CD   1 
ATOM   654  N N    . ARG A 1 94  ? 130.087 109.344 142.839 1.00 31.27  ? 94  ARG U N    1 
ATOM   655  C CA   . ARG A 1 94  ? 130.688 109.925 141.649 1.00 32.39  ? 94  ARG U CA   1 
ATOM   656  C C    . ARG A 1 94  ? 131.955 109.171 141.248 1.00 41.18  ? 94  ARG U C    1 
ATOM   657  O O    . ARG A 1 94  ? 132.584 108.488 142.060 1.00 49.14  ? 94  ARG U O    1 
ATOM   658  C CB   . ARG A 1 94  ? 131.024 111.401 141.876 1.00 31.34  ? 94  ARG U CB   1 
ATOM   659  C CG   . ARG A 1 94  ? 129.899 112.362 141.551 1.00 32.07  ? 94  ARG U CG   1 
ATOM   660  C CD   . ARG A 1 94  ? 128.969 112.593 142.726 1.00 30.05  ? 94  ARG U CD   1 
ATOM   661  N NE   . ARG A 1 94  ? 127.795 113.350 142.308 1.00 32.44  ? 94  ARG U NE   1 
ATOM   662  C CZ   . ARG A 1 94  ? 126.617 112.809 142.027 1.00 35.53  ? 94  ARG U CZ   1 
ATOM   663  N NH1  . ARG A 1 94  ? 126.398 111.514 142.177 1.00 32.71  ? 94  ARG U NH1  1 
ATOM   664  N NH2  . ARG A 1 94  ? 125.635 113.589 141.586 1.00 35.89  ? 94  ARG U NH2  1 
ATOM   665  N N    . TRP A 1 95  ? 132.315 109.305 139.973 1.00 24.64  ? 95  TRP U N    1 
ATOM   666  C CA   . TRP A 1 95  ? 133.629 108.914 139.456 1.00 26.68  ? 95  TRP U CA   1 
ATOM   667  C C    . TRP A 1 95  ? 133.979 107.446 139.710 1.00 29.14  ? 95  TRP U C    1 
ATOM   668  O O    . TRP A 1 95  ? 135.161 107.101 139.788 1.00 40.02  ? 95  TRP U O    1 
ATOM   669  C CB   . TRP A 1 95  ? 134.745 109.797 140.038 1.00 17.07  ? 95  TRP U CB   1 
ATOM   670  C CG   . TRP A 1 95  ? 134.534 111.280 139.938 1.00 21.27  ? 95  TRP U CG   1 
ATOM   671  C CD1  . TRP A 1 95  ? 134.427 112.160 140.973 1.00 23.77  ? 95  TRP U CD1  1 
ATOM   672  C CD2  . TRP A 1 95  ? 134.469 112.065 138.738 1.00 27.78  ? 95  TRP U CD2  1 
ATOM   673  N NE1  . TRP A 1 95  ? 134.268 113.437 140.498 1.00 23.77  ? 95  TRP U NE1  1 
ATOM   674  C CE2  . TRP A 1 95  ? 134.293 113.408 139.129 1.00 27.66  ? 95  TRP U CE2  1 
ATOM   675  C CE3  . TRP A 1 95  ? 134.530 111.761 137.376 1.00 23.21  ? 95  TRP U CE3  1 
ATOM   676  C CZ2  . TRP A 1 95  ? 134.179 114.443 138.205 1.00 24.31  ? 95  TRP U CZ2  1 
ATOM   677  C CZ3  . TRP A 1 95  ? 134.414 112.791 136.461 1.00 20.77  ? 95  TRP U CZ3  1 
ATOM   678  C CH2  . TRP A 1 95  ? 134.240 114.115 136.880 1.00 21.30  ? 95  TRP U CH2  1 
ATOM   679  N N    . ASP A 1 96  ? 133.000 106.550 139.852 1.00 23.57  ? 96  ASP U N    1 
ATOM   680  C CA   . ASP A 1 96  ? 133.398 105.155 140.079 1.00 31.22  ? 96  ASP U CA   1 
ATOM   681  C C    . ASP A 1 96  ? 133.722 104.458 138.761 1.00 41.23  ? 96  ASP U C    1 
ATOM   682  O O    . ASP A 1 96  ? 134.891 104.206 138.452 1.00 51.45  ? 96  ASP U O    1 
ATOM   683  C CB   . ASP A 1 96  ? 132.296 104.406 140.836 1.00 35.77  ? 96  ASP U CB   1 
ATOM   684  C CG   . ASP A 1 96  ? 130.902 104.793 140.381 1.00 42.20  ? 96  ASP U CG   1 
ATOM   685  O OD1  . ASP A 1 96  ? 130.774 105.704 139.538 1.00 43.51  ? 96  ASP U OD1  1 
ATOM   686  O OD2  . ASP A 1 96  ? 129.934 104.173 140.864 1.00 42.58  ? 96  ASP U OD2  1 
ATOM   687  N N    . PHE A 1 97  ? 132.697 104.122 137.976 1.00 34.15  ? 97  PHE U N    1 
ATOM   688  C CA   . PHE A 1 97  ? 132.810 104.010 136.524 1.00 26.36  ? 97  PHE U CA   1 
ATOM   689  C C    . PHE A 1 97  ? 131.567 104.467 135.773 1.00 30.83  ? 97  PHE U C    1 
ATOM   690  O O    . PHE A 1 97  ? 131.686 104.893 134.619 1.00 34.71  ? 97  PHE U O    1 
ATOM   691  C CB   . PHE A 1 97  ? 133.141 102.570 136.103 1.00 26.31  ? 97  PHE U CB   1 
ATOM   692  C CG   . PHE A 1 97  ? 133.347 102.411 134.624 1.00 30.46  ? 97  PHE U CG   1 
ATOM   693  C CD1  . PHE A 1 97  ? 134.539 102.787 134.034 1.00 29.32  ? 97  PHE U CD1  1 
ATOM   694  C CD2  . PHE A 1 97  ? 132.340 101.901 133.822 1.00 30.26  ? 97  PHE U CD2  1 
ATOM   695  C CE1  . PHE A 1 97  ? 134.729 102.650 132.673 1.00 29.47  ? 97  PHE U CE1  1 
ATOM   696  C CE2  . PHE A 1 97  ? 132.523 101.762 132.460 1.00 25.88  ? 97  PHE U CE2  1 
ATOM   697  C CZ   . PHE A 1 97  ? 133.718 102.135 131.885 1.00 27.09  ? 97  PHE U CZ   1 
ATOM   698  N N    . THR A 1 98  ? 130.387 104.413 136.387 1.00 32.10  ? 98  THR U N    1 
ATOM   699  C CA   . THR A 1 98  ? 129.134 104.784 135.741 1.00 33.06  ? 98  THR U CA   1 
ATOM   700  C C    . THR A 1 98  ? 128.789 106.249 135.940 1.00 33.94  ? 98  THR U C    1 
ATOM   701  O O    . THR A 1 98  ? 128.170 106.860 135.060 1.00 39.59  ? 98  THR U O    1 
ATOM   702  C CB   . THR A 1 98  ? 127.997 103.907 136.264 1.00 31.65  ? 98  THR U CB   1 
ATOM   703  O OG1  . THR A 1 98  ? 127.666 104.295 137.602 1.00 38.44  ? 98  THR U OG1  1 
ATOM   704  C CG2  . THR A 1 98  ? 128.409 102.448 136.260 1.00 22.10  ? 98  THR U CG2  1 
ATOM   705  N N    . GLY A 1 99  ? 129.180 106.831 137.073 1.00 26.02  ? 99  GLY U N    1 
ATOM   706  C CA   . GLY A 1 99  ? 129.100 108.272 137.215 1.00 27.63  ? 99  GLY U CA   1 
ATOM   707  C C    . GLY A 1 99  ? 129.962 108.996 136.199 1.00 26.94  ? 99  GLY U C    1 
ATOM   708  O O    . GLY A 1 99  ? 129.565 110.030 135.663 1.00 30.46  ? 99  GLY U O    1 
ATOM   709  N N    . ALA A 1 100 ? 131.144 108.450 135.908 1.00 23.13  ? 100 ALA U N    1 
ATOM   710  C CA   . ALA A 1 100 ? 131.991 109.027 134.868 1.00 23.44  ? 100 ALA U CA   1 
ATOM   711  C C    . ALA A 1 100 ? 131.336 108.920 133.495 1.00 26.83  ? 100 ALA U C    1 
ATOM   712  O O    . ALA A 1 100 ? 131.444 109.844 132.678 1.00 29.76  ? 100 ALA U O    1 
ATOM   713  C CB   . ALA A 1 100 ? 133.358 108.347 134.874 1.00 23.62  ? 100 ALA U CB   1 
ATOM   714  N N    . PHE A 1 101 ? 130.672 107.798 133.220 1.00 18.71  ? 101 PHE U N    1 
ATOM   715  C CA   . PHE A 1 101 ? 129.952 107.645 131.957 1.00 20.81  ? 101 PHE U CA   1 
ATOM   716  C C    . PHE A 1 101 ? 128.821 108.661 131.841 1.00 26.53  ? 101 PHE U C    1 
ATOM   717  O O    . PHE A 1 101 ? 128.649 109.299 130.793 1.00 33.48  ? 101 PHE U O    1 
ATOM   718  C CB   . PHE A 1 101 ? 129.416 106.218 131.841 1.00 22.23  ? 101 PHE U CB   1 
ATOM   719  C CG   . PHE A 1 101 ? 128.956 105.851 130.460 1.00 31.49  ? 101 PHE U CG   1 
ATOM   720  C CD1  . PHE A 1 101 ? 129.867 105.466 129.491 1.00 23.16  ? 101 PHE U CD1  1 
ATOM   721  C CD2  . PHE A 1 101 ? 127.611 105.876 130.134 1.00 29.18  ? 101 PHE U CD2  1 
ATOM   722  C CE1  . PHE A 1 101 ? 129.447 105.129 128.222 1.00 23.67  ? 101 PHE U CE1  1 
ATOM   723  C CE2  . PHE A 1 101 ? 127.184 105.537 128.866 1.00 21.78  ? 101 PHE U CE2  1 
ATOM   724  C CZ   . PHE A 1 101 ? 128.104 105.163 127.910 1.00 25.59  ? 101 PHE U CZ   1 
ATOM   725  N N    . TYR A 1 102 ? 128.052 108.837 132.918 1.00 20.15  ? 102 TYR U N    1 
ATOM   726  C CA   . TYR A 1 102 ? 127.012 109.865 132.938 1.00 24.46  ? 102 TYR U CA   1 
ATOM   727  C C    . TYR A 1 102 ? 127.609 111.254 132.711 1.00 30.55  ? 102 TYR U C    1 
ATOM   728  O O    . TYR A 1 102 ? 127.053 112.063 131.957 1.00 29.35  ? 102 TYR U O    1 
ATOM   729  C CB   . TYR A 1 102 ? 126.266 109.804 134.270 1.00 21.52  ? 102 TYR U CB   1 
ATOM   730  C CG   . TYR A 1 102 ? 124.829 110.279 134.237 1.00 30.51  ? 102 TYR U CG   1 
ATOM   731  C CD1  . TYR A 1 102 ? 124.381 111.147 133.249 1.00 33.47  ? 102 TYR U CD1  1 
ATOM   732  C CD2  . TYR A 1 102 ? 123.923 109.866 135.203 1.00 24.89  ? 102 TYR U CD2  1 
ATOM   733  C CE1  . TYR A 1 102 ? 123.070 111.583 133.222 1.00 32.64  ? 102 TYR U CE1  1 
ATOM   734  C CE2  . TYR A 1 102 ? 122.612 110.297 135.184 1.00 26.44  ? 102 TYR U CE2  1 
ATOM   735  C CZ   . TYR A 1 102 ? 122.189 111.153 134.190 1.00 29.36  ? 102 TYR U CZ   1 
ATOM   736  O OH   . TYR A 1 102 ? 120.887 111.586 134.169 1.00 35.53  ? 102 TYR U OH   1 
ATOM   737  N N    . PHE A 1 103 ? 128.742 111.538 133.356 1.00 24.29  ? 103 PHE U N    1 
ATOM   738  C CA   . PHE A 1 103 ? 129.380 112.845 133.232 1.00 20.28  ? 103 PHE U CA   1 
ATOM   739  C C    . PHE A 1 103 ? 129.817 113.114 131.799 1.00 21.90  ? 103 PHE U C    1 
ATOM   740  O O    . PHE A 1 103 ? 129.544 114.186 131.244 1.00 28.27  ? 103 PHE U O    1 
ATOM   741  C CB   . PHE A 1 103 ? 130.571 112.921 134.192 1.00 20.48  ? 103 PHE U CB   1 
ATOM   742  C CG   . PHE A 1 103 ? 131.466 114.107 133.963 1.00 28.62  ? 103 PHE U CG   1 
ATOM   743  C CD1  . PHE A 1 103 ? 131.068 115.380 134.338 1.00 20.23  ? 103 PHE U CD1  1 
ATOM   744  C CD2  . PHE A 1 103 ? 132.710 113.947 133.372 1.00 26.97  ? 103 PHE U CD2  1 
ATOM   745  C CE1  . PHE A 1 103 ? 131.893 116.468 134.130 1.00 20.76  ? 103 PHE U CE1  1 
ATOM   746  C CE2  . PHE A 1 103 ? 133.536 115.029 133.159 1.00 24.37  ? 103 PHE U CE2  1 
ATOM   747  C CZ   . PHE A 1 103 ? 133.127 116.292 133.539 1.00 23.09  ? 103 PHE U CZ   1 
ATOM   748  N N    . VAL A 1 104 ? 130.501 112.154 131.176 1.00 23.41  ? 104 VAL U N    1 
ATOM   749  C CA   . VAL A 1 104 ? 130.972 112.374 129.812 1.00 24.13  ? 104 VAL U CA   1 
ATOM   750  C C    . VAL A 1 104 ? 129.792 112.469 128.852 1.00 21.55  ? 104 VAL U C    1 
ATOM   751  O O    . VAL A 1 104 ? 129.843 113.225 127.871 1.00 23.96  ? 104 VAL U O    1 
ATOM   752  C CB   . VAL A 1 104 ? 131.981 111.288 129.381 1.00 22.84  ? 104 VAL U CB   1 
ATOM   753  C CG1  . VAL A 1 104 ? 133.208 111.316 130.280 1.00 18.28  ? 104 VAL U CG1  1 
ATOM   754  C CG2  . VAL A 1 104 ? 131.349 109.910 129.370 1.00 18.37  ? 104 VAL U CG2  1 
ATOM   755  N N    . GLY A 1 105 ? 128.716 111.718 129.109 1.00 31.69  ? 105 GLY U N    1 
ATOM   756  C CA   . GLY A 1 105 ? 127.521 111.859 128.293 1.00 20.64  ? 105 GLY U CA   1 
ATOM   757  C C    . GLY A 1 105 ? 126.903 113.242 128.388 1.00 21.40  ? 105 GLY U C    1 
ATOM   758  O O    . GLY A 1 105 ? 126.461 113.803 127.386 1.00 25.60  ? 105 GLY U O    1 
ATOM   759  N N    . THR A 1 106 ? 126.852 113.804 129.601 1.00 29.37  ? 106 THR U N    1 
ATOM   760  C CA   . THR A 1 106 ? 126.341 115.164 129.752 1.00 23.58  ? 106 THR U CA   1 
ATOM   761  C C    . THR A 1 106 ? 127.288 116.193 129.147 1.00 27.21  ? 106 THR U C    1 
ATOM   762  O O    . THR A 1 106 ? 126.854 117.287 128.764 1.00 32.38  ? 106 THR U O    1 
ATOM   763  C CB   . THR A 1 106 ? 126.091 115.495 131.225 1.00 25.07  ? 106 THR U CB   1 
ATOM   764  O OG1  . THR A 1 106 ? 127.306 115.347 131.965 1.00 28.40  ? 106 THR U OG1  1 
ATOM   765  C CG2  . THR A 1 106 ? 125.026 114.583 131.809 1.00 26.50  ? 106 THR U CG2  1 
ATOM   766  N N    . VAL A 1 107 ? 128.576 115.865 129.052 1.00 25.97  ? 107 VAL U N    1 
ATOM   767  C CA   . VAL A 1 107 ? 129.551 116.815 128.523 1.00 15.18  ? 107 VAL U CA   1 
ATOM   768  C C    . VAL A 1 107 ? 129.477 116.874 127.003 1.00 17.40  ? 107 VAL U C    1 
ATOM   769  O O    . VAL A 1 107 ? 129.393 117.958 126.415 1.00 25.07  ? 107 VAL U O    1 
ATOM   770  C CB   . VAL A 1 107 ? 130.968 116.459 129.007 1.00 18.94  ? 107 VAL U CB   1 
ATOM   771  C CG1  . VAL A 1 107 ? 132.014 117.141 128.140 1.00 21.84  ? 107 VAL U CG1  1 
ATOM   772  C CG2  . VAL A 1 107 ? 131.149 116.863 130.461 1.00 18.54  ? 107 VAL U CG2  1 
ATOM   773  N N    . VAL A 1 108 ? 129.499 115.711 126.344 1.00 24.86  ? 108 VAL U N    1 
ATOM   774  C CA   . VAL A 1 108 ? 129.578 115.688 124.885 1.00 21.42  ? 108 VAL U CA   1 
ATOM   775  C C    . VAL A 1 108 ? 128.300 116.237 124.252 1.00 26.22  ? 108 VAL U C    1 
ATOM   776  O O    . VAL A 1 108 ? 128.335 116.772 123.141 1.00 30.03  ? 108 VAL U O    1 
ATOM   777  C CB   . VAL A 1 108 ? 129.883 114.264 124.377 1.00 17.79  ? 108 VAL U CB   1 
ATOM   778  C CG1  . VAL A 1 108 ? 131.245 113.804 124.879 1.00 18.85  ? 108 VAL U CG1  1 
ATOM   779  C CG2  . VAL A 1 108 ? 128.787 113.295 124.792 1.00 18.11  ? 108 VAL U CG2  1 
ATOM   780  N N    . SER A 1 109 ? 127.164 116.118 124.935 1.00 29.84  ? 109 SER U N    1 
ATOM   781  C CA   . SER A 1 109 ? 125.899 116.641 124.437 1.00 19.81  ? 109 SER U CA   1 
ATOM   782  C C    . SER A 1 109 ? 125.672 118.107 124.793 1.00 25.93  ? 109 SER U C    1 
ATOM   783  O O    . SER A 1 109 ? 124.636 118.661 124.419 1.00 26.90  ? 109 SER U O    1 
ATOM   784  C CB   . SER A 1 109 ? 124.739 115.800 124.975 1.00 23.94  ? 109 SER U CB   1 
ATOM   785  O OG   . SER A 1 109 ? 124.770 115.748 126.391 1.00 23.82  ? 109 SER U OG   1 
ATOM   786  N N    . THR A 1 110 ? 126.622 118.743 125.480 1.00 29.78  ? 110 THR U N    1 
ATOM   787  C CA   . THR A 1 110 ? 126.524 120.141 125.922 1.00 26.17  ? 110 THR U CA   1 
ATOM   788  C C    . THR A 1 110 ? 125.261 120.389 126.745 1.00 24.62  ? 110 THR U C    1 
ATOM   789  O O    . THR A 1 110 ? 124.644 121.454 126.671 1.00 33.57  ? 110 THR U O    1 
ATOM   790  C CB   . THR A 1 110 ? 126.601 121.124 124.745 1.00 29.82  ? 110 THR U CB   1 
ATOM   791  O OG1  . THR A 1 110 ? 125.805 120.662 123.647 1.00 35.96  ? 110 THR U OG1  1 
ATOM   792  C CG2  . THR A 1 110 ? 128.037 121.296 124.283 1.00 27.26  ? 110 THR U CG2  1 
ATOM   793  N N    . ILE A 1 111 ? 124.882 119.404 127.555 1.00 14.87  ? 111 ILE U N    1 
ATOM   794  C CA   . ILE A 1 111 ? 123.783 119.588 128.499 1.00 19.30  ? 111 ILE U CA   1 
ATOM   795  C C    . ILE A 1 111 ? 124.286 120.288 129.756 1.00 28.91  ? 111 ILE U C    1 
ATOM   796  O O    . ILE A 1 111 ? 123.752 121.323 130.171 1.00 35.69  ? 111 ILE U O    1 
ATOM   797  C CB   . ILE A 1 111 ? 123.113 118.240 128.821 1.00 27.41  ? 111 ILE U CB   1 
ATOM   798  C CG1  . ILE A 1 111 ? 122.405 117.695 127.580 1.00 28.99  ? 111 ILE U CG1  1 
ATOM   799  C CG2  . ILE A 1 111 ? 122.132 118.391 129.974 1.00 17.79  ? 111 ILE U CG2  1 
ATOM   800  C CD1  . ILE A 1 111 ? 121.700 116.378 127.805 1.00 25.36  ? 111 ILE U CD1  1 
ATOM   801  N N    . GLY A 1 112 ? 125.313 119.721 130.382 1.00 25.14  ? 112 GLY U N    1 
ATOM   802  C CA   . GLY A 1 112 ? 125.965 120.327 131.527 1.00 17.29  ? 112 GLY U CA   1 
ATOM   803  C C    . GLY A 1 112 ? 125.143 120.503 132.786 1.00 23.62  ? 112 GLY U C    1 
ATOM   804  O O    . GLY A 1 112 ? 125.085 121.611 133.328 1.00 30.88  ? 112 GLY U O    1 
ATOM   805  N N    . PHE A 1 113 ? 124.494 119.431 133.246 1.00 27.26  ? 113 PHE U N    1 
ATOM   806  C CA   . PHE A 1 113 ? 123.650 119.503 134.438 1.00 21.69  ? 113 PHE U CA   1 
ATOM   807  C C    . PHE A 1 113 ? 124.372 120.191 135.594 1.00 29.65  ? 113 PHE U C    1 
ATOM   808  O O    . PHE A 1 113 ? 123.767 120.969 136.340 1.00 35.52  ? 113 PHE U O    1 
ATOM   809  C CB   . PHE A 1 113 ? 123.191 118.104 134.852 1.00 20.93  ? 113 PHE U CB   1 
ATOM   810  C CG   . PHE A 1 113 ? 122.036 117.579 134.051 1.00 31.55  ? 113 PHE U CG   1 
ATOM   811  C CD1  . PHE A 1 113 ? 120.966 118.402 133.740 1.00 37.21  ? 113 PHE U CD1  1 
ATOM   812  C CD2  . PHE A 1 113 ? 122.014 116.264 133.621 1.00 30.69  ? 113 PHE U CD2  1 
ATOM   813  C CE1  . PHE A 1 113 ? 119.895 117.921 133.010 1.00 32.78  ? 113 PHE U CE1  1 
ATOM   814  C CE2  . PHE A 1 113 ? 120.946 115.780 132.888 1.00 27.63  ? 113 PHE U CE2  1 
ATOM   815  C CZ   . PHE A 1 113 ? 119.886 116.610 132.582 1.00 28.67  ? 113 PHE U CZ   1 
ATOM   816  N N    . GLY A 1 114 ? 125.662 119.903 135.767 1.00 28.40  ? 114 GLY U N    1 
ATOM   817  C CA   . GLY A 1 114 ? 126.436 120.451 136.860 1.00 30.73  ? 114 GLY U CA   1 
ATOM   818  C C    . GLY A 1 114 ? 126.443 119.638 138.134 1.00 31.47  ? 114 GLY U C    1 
ATOM   819  O O    . GLY A 1 114 ? 127.083 120.054 139.109 1.00 36.47  ? 114 GLY U O    1 
ATOM   820  N N    . MET A 1 115 ? 125.741 118.503 138.174 1.00 29.30  ? 115 MET U N    1 
ATOM   821  C CA   . MET A 1 115 ? 125.782 117.645 139.352 1.00 28.12  ? 115 MET U CA   1 
ATOM   822  C C    . MET A 1 115 ? 127.168 117.054 139.592 1.00 32.04  ? 115 MET U C    1 
ATOM   823  O O    . MET A 1 115 ? 127.465 116.638 140.716 1.00 35.49  ? 115 MET U O    1 
ATOM   824  C CB   . MET A 1 115 ? 124.744 116.529 139.228 1.00 27.42  ? 115 MET U CB   1 
ATOM   825  C CG   . MET A 1 115 ? 125.194 115.327 138.415 1.00 31.99  ? 115 MET U CG   1 
ATOM   826  S SD   . MET A 1 115 ? 124.950 115.542 136.645 1.00 47.55  ? 115 MET U SD   1 
ATOM   827  C CE   . MET A 1 115 ? 125.473 113.940 136.036 1.00 24.77  ? 115 MET U CE   1 
ATOM   828  N N    . THR A 1 116 ? 128.018 117.003 138.565 1.00 30.17  ? 116 THR U N    1 
ATOM   829  C CA   . THR A 1 116 ? 129.360 116.442 138.681 1.00 23.56  ? 116 THR U CA   1 
ATOM   830  C C    . THR A 1 116 ? 130.315 117.296 137.863 1.00 27.59  ? 116 THR U C    1 
ATOM   831  O O    . THR A 1 116 ? 130.136 117.434 136.649 1.00 35.87  ? 116 THR U O    1 
ATOM   832  C CB   . THR A 1 116 ? 129.390 114.985 138.203 1.00 21.09  ? 116 THR U CB   1 
ATOM   833  O OG1  . THR A 1 116 ? 128.387 114.232 138.894 1.00 33.26  ? 116 THR U OG1  1 
ATOM   834  C CG2  . THR A 1 116 ? 130.745 114.363 138.480 1.00 18.20  ? 116 THR U CG2  1 
ATOM   835  N N    . THR A 1 117 ? 131.311 117.882 138.521 1.00 31.30  ? 117 THR U N    1 
ATOM   836  C CA   . THR A 1 117 ? 132.267 118.762 137.868 1.00 27.19  ? 117 THR U CA   1 
ATOM   837  C C    . THR A 1 117 ? 133.691 118.409 138.271 1.00 30.12  ? 117 THR U C    1 
ATOM   838  O O    . THR A 1 117 ? 133.924 117.926 139.386 1.00 28.41  ? 117 THR U O    1 
ATOM   839  C CB   . THR A 1 117 ? 131.993 120.234 138.218 1.00 26.57  ? 117 THR U CB   1 
ATOM   840  O OG1  . THR A 1 117 ? 131.711 120.354 139.615 1.00 40.61  ? 117 THR U OG1  1 
ATOM   841  C CG2  . THR A 1 117 ? 130.814 120.761 137.421 1.00 21.60  ? 117 THR U CG2  1 
ATOM   842  N N    . PRO A 1 118 ? 134.664 118.634 137.385 1.00 30.04  ? 118 PRO U N    1 
ATOM   843  C CA   . PRO A 1 118 ? 136.068 118.417 137.754 1.00 27.21  ? 118 PRO U CA   1 
ATOM   844  C C    . PRO A 1 118 ? 136.513 119.367 138.858 1.00 28.87  ? 118 PRO U C    1 
ATOM   845  O O    . PRO A 1 118 ? 136.096 120.526 138.912 1.00 35.99  ? 118 PRO U O    1 
ATOM   846  C CB   . PRO A 1 118 ? 136.826 118.678 136.450 1.00 24.75  ? 118 PRO U CB   1 
ATOM   847  C CG   . PRO A 1 118 ? 135.804 118.539 135.370 1.00 28.98  ? 118 PRO U CG   1 
ATOM   848  C CD   . PRO A 1 118 ? 134.517 119.008 135.970 1.00 29.64  ? 118 PRO U CD   1 
ATOM   849  N N    . ALA A 1 119 ? 137.386 118.868 139.736 1.00 24.35  ? 119 ALA U N    1 
ATOM   850  C CA   . ALA A 1 119 ? 137.858 119.650 140.871 1.00 25.87  ? 119 ALA U CA   1 
ATOM   851  C C    . ALA A 1 119 ? 139.375 119.710 141.008 1.00 33.19  ? 119 ALA U C    1 
ATOM   852  O O    . ALA A 1 119 ? 139.862 120.329 141.961 1.00 41.40  ? 119 ALA U O    1 
ATOM   853  C CB   . ALA A 1 119 ? 137.264 119.102 142.176 1.00 30.10  ? 119 ALA U CB   1 
ATOM   854  N N    . THR A 1 120 ? 140.134 119.104 140.100 1.00 32.22  ? 120 THR U N    1 
ATOM   855  C CA   . THR A 1 120 ? 141.584 119.063 140.205 1.00 30.23  ? 120 THR U CA   1 
ATOM   856  C C    . THR A 1 120 ? 142.223 119.660 138.958 1.00 33.79  ? 120 THR U C    1 
ATOM   857  O O    . THR A 1 120 ? 141.634 119.657 137.876 1.00 40.07  ? 120 THR U O    1 
ATOM   858  C CB   . THR A 1 120 ? 142.101 117.629 140.401 1.00 30.58  ? 120 THR U CB   1 
ATOM   859  O OG1  . THR A 1 120 ? 141.794 116.844 139.243 1.00 26.06  ? 120 THR U OG1  1 
ATOM   860  C CG2  . THR A 1 120 ? 141.461 116.991 141.622 1.00 29.03  ? 120 THR U CG2  1 
ATOM   861  N N    . VAL A 1 121 ? 143.434 120.185 139.129 1.00 37.91  ? 121 VAL U N    1 
ATOM   862  C CA   . VAL A 1 121 ? 144.248 120.596 137.989 1.00 32.37  ? 121 VAL U CA   1 
ATOM   863  C C    . VAL A 1 121 ? 144.739 119.344 137.271 1.00 39.22  ? 121 VAL U C    1 
ATOM   864  O O    . VAL A 1 121 ? 145.373 118.472 137.872 1.00 42.33  ? 121 VAL U O    1 
ATOM   865  C CB   . VAL A 1 121 ? 145.421 121.477 138.436 1.00 33.60  ? 121 VAL U CB   1 
ATOM   866  C CG1  . VAL A 1 121 ? 146.390 121.698 137.285 1.00 32.03  ? 121 VAL U CG1  1 
ATOM   867  C CG2  . VAL A 1 121 ? 144.915 122.805 138.969 1.00 37.47  ? 121 VAL U CG2  1 
ATOM   868  N N    . GLY A 1 122 ? 144.441 119.253 135.979 1.00 30.56  ? 122 GLY U N    1 
ATOM   869  C CA   . GLY A 1 122 ? 144.706 118.049 135.222 1.00 25.90  ? 122 GLY U CA   1 
ATOM   870  C C    . GLY A 1 122 ? 143.408 117.467 134.704 1.00 31.90  ? 122 GLY U C    1 
ATOM   871  O O    . GLY A 1 122 ? 143.322 117.035 133.551 1.00 43.82  ? 122 GLY U O    1 
ATOM   872  N N    . GLY A 1 123 ? 142.384 117.470 135.558 1.00 23.97  ? 123 GLY U N    1 
ATOM   873  C CA   . GLY A 1 123 ? 141.036 117.146 135.141 1.00 22.86  ? 123 GLY U CA   1 
ATOM   874  C C    . GLY A 1 123 ? 140.299 118.275 134.456 1.00 28.22  ? 123 GLY U C    1 
ATOM   875  O O    . GLY A 1 123 ? 139.263 118.030 133.834 1.00 32.49  ? 123 GLY U O    1 
ATOM   876  N N    . LYS A 1 124 ? 140.816 119.501 134.541 1.00 32.30  ? 124 LYS U N    1 
ATOM   877  C CA   . LYS A 1 124 ? 140.227 120.646 133.857 1.00 27.53  ? 124 LYS U CA   1 
ATOM   878  C C    . LYS A 1 124 ? 140.870 120.894 132.496 1.00 31.78  ? 124 LYS U C    1 
ATOM   879  O O    . LYS A 1 124 ? 140.182 121.312 131.558 1.00 34.08  ? 124 LYS U O    1 
ATOM   880  C CB   . LYS A 1 124 ? 140.349 121.899 134.725 1.00 26.83  ? 124 LYS U CB   1 
ATOM   881  C CG   . LYS A 1 124 ? 139.576 121.811 136.030 1.00 24.30  ? 124 LYS U CG   1 
ATOM   882  C CD   . LYS A 1 124 ? 139.643 123.113 136.801 1.00 21.48  ? 124 LYS U CD   1 
ATOM   883  C CE   . LYS A 1 124 ? 138.785 123.040 138.050 1.00 25.22  ? 124 LYS U CE   1 
ATOM   884  N NZ   . LYS A 1 124 ? 138.863 124.286 138.854 1.00 30.22  ? 124 LYS U NZ   1 
ATOM   885  N N    . ILE A 1 125 ? 142.174 120.648 132.369 1.00 25.97  ? 125 ILE U N    1 
ATOM   886  C CA   . ILE A 1 125 ? 142.810 120.692 131.056 1.00 25.92  ? 125 ILE U CA   1 
ATOM   887  C C    . ILE A 1 125 ? 142.264 119.571 130.181 1.00 31.30  ? 125 ILE U C    1 
ATOM   888  O O    . ILE A 1 125 ? 141.896 119.780 129.014 1.00 33.77  ? 125 ILE U O    1 
ATOM   889  C CB   . ILE A 1 125 ? 144.341 120.602 131.198 1.00 23.43  ? 125 ILE U CB   1 
ATOM   890  C CG1  . ILE A 1 125 ? 144.825 121.504 132.333 1.00 19.28  ? 125 ILE U CG1  1 
ATOM   891  C CG2  . ILE A 1 125 ? 145.022 120.976 129.896 1.00 31.79  ? 125 ILE U CG2  1 
ATOM   892  C CD1  . ILE A 1 125 ? 146.297 121.354 132.632 1.00 22.18  ? 125 ILE U CD1  1 
ATOM   893  N N    . PHE A 1 126 ? 142.201 118.359 130.742 1.00 24.97  ? 126 PHE U N    1 
ATOM   894  C CA   . PHE A 1 126 ? 141.648 117.229 130.009 1.00 26.21  ? 126 PHE U CA   1 
ATOM   895  C C    . PHE A 1 126 ? 140.185 117.463 129.669 1.00 25.12  ? 126 PHE U C    1 
ATOM   896  O O    . PHE A 1 126 ? 139.725 117.038 128.606 1.00 31.02  ? 126 PHE U O    1 
ATOM   897  C CB   . PHE A 1 126 ? 141.810 115.943 130.821 1.00 23.24  ? 126 PHE U CB   1 
ATOM   898  C CG   . PHE A 1 126 ? 141.405 114.701 130.079 1.00 27.70  ? 126 PHE U CG   1 
ATOM   899  C CD1  . PHE A 1 126 ? 142.151 114.246 129.005 1.00 25.86  ? 126 PHE U CD1  1 
ATOM   900  C CD2  . PHE A 1 126 ? 140.283 113.989 130.459 1.00 27.93  ? 126 PHE U CD2  1 
ATOM   901  C CE1  . PHE A 1 126 ? 141.779 113.106 128.321 1.00 25.38  ? 126 PHE U CE1  1 
ATOM   902  C CE2  . PHE A 1 126 ? 139.906 112.850 129.782 1.00 23.71  ? 126 PHE U CE2  1 
ATOM   903  C CZ   . PHE A 1 126 ? 140.654 112.407 128.711 1.00 29.01  ? 126 PHE U CZ   1 
ATOM   904  N N    . LEU A 1 127 ? 139.446 118.148 130.542 1.00 17.26  ? 127 LEU U N    1 
ATOM   905  C CA   . LEU A 1 127 ? 138.067 118.503 130.228 1.00 22.32  ? 127 LEU U CA   1 
ATOM   906  C C    . LEU A 1 127 ? 138.005 119.395 128.994 1.00 27.70  ? 127 LEU U C    1 
ATOM   907  O O    . LEU A 1 127 ? 137.178 119.182 128.100 1.00 32.59  ? 127 LEU U O    1 
ATOM   908  C CB   . LEU A 1 127 ? 137.418 119.194 131.430 1.00 24.52  ? 127 LEU U CB   1 
ATOM   909  C CG   . LEU A 1 127 ? 135.911 119.478 131.421 1.00 23.12  ? 127 LEU U CG   1 
ATOM   910  C CD1  . LEU A 1 127 ? 135.598 120.851 130.842 1.00 22.65  ? 127 LEU U CD1  1 
ATOM   911  C CD2  . LEU A 1 127 ? 135.146 118.393 130.677 1.00 24.77  ? 127 LEU U CD2  1 
ATOM   912  N N    . ILE A 1 128 ? 138.902 120.380 128.917 1.00 28.12  ? 128 ILE U N    1 
ATOM   913  C CA   . ILE A 1 128 ? 138.912 121.310 127.791 1.00 27.24  ? 128 ILE U CA   1 
ATOM   914  C C    . ILE A 1 128 ? 139.201 120.564 126.496 1.00 28.67  ? 128 ILE U C    1 
ATOM   915  O O    . ILE A 1 128 ? 138.474 120.704 125.504 1.00 27.72  ? 128 ILE U O    1 
ATOM   916  C CB   . ILE A 1 128 ? 139.926 122.439 128.036 1.00 25.00  ? 128 ILE U CB   1 
ATOM   917  C CG1  . ILE A 1 128 ? 139.438 123.356 129.159 1.00 25.09  ? 128 ILE U CG1  1 
ATOM   918  C CG2  . ILE A 1 128 ? 140.169 123.234 126.765 1.00 23.74  ? 128 ILE U CG2  1 
ATOM   919  C CD1  . ILE A 1 128 ? 140.398 124.470 129.503 1.00 20.82  ? 128 ILE U CD1  1 
ATOM   920  N N    . PHE A 1 129 ? 140.262 119.755 126.489 1.00 29.90  ? 129 PHE U N    1 
ATOM   921  C CA   . PHE A 1 129 ? 140.617 119.036 125.265 1.00 25.51  ? 129 PHE U CA   1 
ATOM   922  C C    . PHE A 1 129 ? 139.544 118.017 124.881 1.00 27.53  ? 129 PHE U C    1 
ATOM   923  O O    . PHE A 1 129 ? 139.198 117.886 123.698 1.00 30.56  ? 129 PHE U O    1 
ATOM   924  C CB   . PHE A 1 129 ? 141.976 118.356 125.431 1.00 24.33  ? 129 PHE U CB   1 
ATOM   925  C CG   . PHE A 1 129 ? 143.141 119.296 125.314 1.00 28.40  ? 129 PHE U CG   1 
ATOM   926  C CD1  . PHE A 1 129 ? 143.602 119.994 126.419 1.00 31.13  ? 129 PHE U CD1  1 
ATOM   927  C CD2  . PHE A 1 129 ? 143.769 119.496 124.095 1.00 33.80  ? 129 PHE U CD2  1 
ATOM   928  C CE1  . PHE A 1 129 ? 144.672 120.860 126.312 1.00 34.27  ? 129 PHE U CE1  1 
ATOM   929  C CE2  . PHE A 1 129 ? 144.837 120.362 123.984 1.00 34.55  ? 129 PHE U CE2  1 
ATOM   930  C CZ   . PHE A 1 129 ? 145.290 121.046 125.094 1.00 34.70  ? 129 PHE U CZ   1 
ATOM   931  N N    . TYR A 1 130 ? 138.997 117.300 125.868 1.00 25.83  ? 130 TYR U N    1 
ATOM   932  C CA   . TYR A 1 130 ? 137.958 116.313 125.605 1.00 24.76  ? 130 TYR U CA   1 
ATOM   933  C C    . TYR A 1 130 ? 136.732 116.958 124.972 1.00 27.20  ? 130 TYR U C    1 
ATOM   934  O O    . TYR A 1 130 ? 136.201 116.460 123.974 1.00 28.21  ? 130 TYR U O    1 
ATOM   935  C CB   . TYR A 1 130 ? 137.589 115.606 126.911 1.00 16.82  ? 130 TYR U CB   1 
ATOM   936  C CG   . TYR A 1 130 ? 136.781 114.341 126.746 1.00 24.13  ? 130 TYR U CG   1 
ATOM   937  C CD1  . TYR A 1 130 ? 137.400 113.130 126.464 1.00 25.00  ? 130 TYR U CD1  1 
ATOM   938  C CD2  . TYR A 1 130 ? 135.400 114.352 126.883 1.00 23.41  ? 130 TYR U CD2  1 
ATOM   939  C CE1  . TYR A 1 130 ? 136.665 111.971 126.319 1.00 19.82  ? 130 TYR U CE1  1 
ATOM   940  C CE2  . TYR A 1 130 ? 134.657 113.200 126.738 1.00 24.53  ? 130 TYR U CE2  1 
ATOM   941  C CZ   . TYR A 1 130 ? 135.296 112.013 126.455 1.00 22.75  ? 130 TYR U CZ   1 
ATOM   942  O OH   . TYR A 1 130 ? 134.556 110.863 126.311 1.00 31.96  ? 130 TYR U OH   1 
ATOM   943  N N    . GLY A 1 131 ? 136.271 118.078 125.534 1.00 22.88  ? 131 GLY U N    1 
ATOM   944  C CA   . GLY A 1 131 ? 135.124 118.760 124.953 1.00 19.75  ? 131 GLY U CA   1 
ATOM   945  C C    . GLY A 1 131 ? 135.415 119.299 123.567 1.00 21.49  ? 131 GLY U C    1 
ATOM   946  O O    . GLY A 1 131 ? 134.593 119.168 122.651 1.00 26.60  ? 131 GLY U O    1 
ATOM   947  N N    . LEU A 1 132 ? 136.610 119.877 123.388 1.00 26.51  ? 132 LEU U N    1 
ATOM   948  C CA   . LEU A 1 132 ? 137.003 120.445 122.102 1.00 26.04  ? 132 LEU U CA   1 
ATOM   949  C C    . LEU A 1 132 ? 137.013 119.387 121.006 1.00 23.60  ? 132 LEU U C    1 
ATOM   950  O O    . LEU A 1 132 ? 136.703 119.683 119.846 1.00 29.30  ? 132 LEU U O    1 
ATOM   951  C CB   . LEU A 1 132 ? 138.374 121.103 122.227 1.00 25.86  ? 132 LEU U CB   1 
ATOM   952  C CG   . LEU A 1 132 ? 138.844 121.993 121.074 1.00 29.52  ? 132 LEU U CG   1 
ATOM   953  C CD1  . LEU A 1 132 ? 138.042 123.281 121.031 1.00 29.89  ? 132 LEU U CD1  1 
ATOM   954  C CD2  . LEU A 1 132 ? 140.329 122.289 121.209 1.00 30.54  ? 132 LEU U CD2  1 
ATOM   955  N N    . VAL A 1 133 ? 137.386 118.153 121.346 1.00 30.06  ? 133 VAL U N    1 
ATOM   956  C CA   . VAL A 1 133 ? 137.375 117.088 120.346 1.00 27.39  ? 133 VAL U CA   1 
ATOM   957  C C    . VAL A 1 133 ? 136.017 116.390 120.236 1.00 29.19  ? 133 VAL U C    1 
ATOM   958  O O    . VAL A 1 133 ? 135.705 115.827 119.177 1.00 25.34  ? 133 VAL U O    1 
ATOM   959  C CB   . VAL A 1 133 ? 138.480 116.056 120.633 1.00 27.89  ? 133 VAL U CB   1 
ATOM   960  C CG1  . VAL A 1 133 ? 138.609 115.057 119.490 1.00 21.06  ? 133 VAL U CG1  1 
ATOM   961  C CG2  . VAL A 1 133 ? 139.812 116.755 120.849 1.00 26.65  ? 133 VAL U CG2  1 
ATOM   962  N N    . GLY A 1 134 ? 135.182 116.456 121.271 1.00 28.23  ? 134 GLY U N    1 
ATOM   963  C CA   . GLY A 1 134 ? 133.975 115.647 121.296 1.00 16.94  ? 134 GLY U CA   1 
ATOM   964  C C    . GLY A 1 134 ? 132.656 116.301 120.937 1.00 21.53  ? 134 GLY U C    1 
ATOM   965  O O    . GLY A 1 134 ? 131.758 115.617 120.433 1.00 24.13  ? 134 GLY U O    1 
ATOM   966  N N    . CYS A 1 135 ? 132.499 117.601 121.189 1.00 25.79  ? 135 CYS U N    1 
ATOM   967  C CA   . CYS A 1 135 ? 131.242 118.262 120.836 1.00 22.99  ? 135 CYS U CA   1 
ATOM   968  C C    . CYS A 1 135 ? 130.960 118.298 119.334 1.00 30.57  ? 135 CYS U C    1 
ATOM   969  O O    . CYS A 1 135 ? 129.815 118.002 118.936 1.00 37.05  ? 135 CYS U O    1 
ATOM   970  C CB   . CYS A 1 135 ? 131.223 119.671 121.442 1.00 29.67  ? 135 CYS U CB   1 
ATOM   971  S SG   . CYS A 1 135 ? 131.287 119.704 123.249 1.00 33.91  ? 135 CYS U SG   1 
ATOM   972  N N    . PRO A 1 136 ? 131.915 118.636 118.455 1.00 26.56  ? 136 PRO U N    1 
ATOM   973  C CA   . PRO A 1 136 ? 131.621 118.578 117.012 1.00 17.63  ? 136 PRO U CA   1 
ATOM   974  C C    . PRO A 1 136 ? 131.193 117.206 116.514 1.00 23.78  ? 136 PRO U C    1 
ATOM   975  O O    . PRO A 1 136 ? 130.370 117.126 115.594 1.00 33.79  ? 136 PRO U O    1 
ATOM   976  C CB   . PRO A 1 136 ? 132.946 119.022 116.374 1.00 24.83  ? 136 PRO U CB   1 
ATOM   977  C CG   . PRO A 1 136 ? 133.590 119.862 117.410 1.00 20.88  ? 136 PRO U CG   1 
ATOM   978  C CD   . PRO A 1 136 ? 133.243 119.225 118.711 1.00 16.84  ? 136 PRO U CD   1 
ATOM   979  N N    . SER A 1 137 ? 131.720 116.123 117.093 1.00 19.65  ? 137 SER U N    1 
ATOM   980  C CA   . SER A 1 137 ? 131.295 114.790 116.676 1.00 17.45  ? 137 SER U CA   1 
ATOM   981  C C    . SER A 1 137 ? 129.815 114.567 116.967 1.00 24.73  ? 137 SER U C    1 
ATOM   982  O O    . SER A 1 137 ? 129.090 114.003 116.140 1.00 38.69  ? 137 SER U O    1 
ATOM   983  C CB   . SER A 1 137 ? 132.151 113.730 117.365 1.00 26.16  ? 137 SER U CB   1 
ATOM   984  O OG   . SER A 1 137 ? 133.529 114.010 117.213 1.00 33.18  ? 137 SER U OG   1 
ATOM   985  N N    . THR A 1 138 ? 129.349 115.009 118.134 1.00 19.29  ? 138 THR U N    1 
ATOM   986  C CA   . THR A 1 138 ? 127.936 114.855 118.473 1.00 24.56  ? 138 THR U CA   1 
ATOM   987  C C    . THR A 1 138 ? 127.056 115.740 117.594 1.00 23.27  ? 138 THR U C    1 
ATOM   988  O O    . THR A 1 138 ? 125.955 115.335 117.197 1.00 29.21  ? 138 THR U O    1 
ATOM   989  C CB   . THR A 1 138 ? 127.721 115.172 119.952 1.00 27.23  ? 138 THR U CB   1 
ATOM   990  O OG1  . THR A 1 138 ? 128.760 114.562 120.723 1.00 26.68  ? 138 THR U OG1  1 
ATOM   991  C CG2  . THR A 1 138 ? 126.375 114.645 120.423 1.00 25.72  ? 138 THR U CG2  1 
ATOM   992  N N    . ILE A 1 139 ? 127.527 116.947 117.269 1.00 19.80  ? 139 ILE U N    1 
ATOM   993  C CA   . ILE A 1 139 ? 126.779 117.801 116.348 1.00 24.65  ? 139 ILE U CA   1 
ATOM   994  C C    . ILE A 1 139 ? 126.640 117.124 114.986 1.00 30.49  ? 139 ILE U C    1 
ATOM   995  O O    . ILE A 1 139 ? 125.557 117.115 114.379 1.00 33.83  ? 139 ILE U O    1 
ATOM   996  C CB   . ILE A 1 139 ? 127.454 119.182 116.236 1.00 26.16  ? 139 ILE U CB   1 
ATOM   997  C CG1  . ILE A 1 139 ? 127.397 119.910 117.578 1.00 21.75  ? 139 ILE U CG1  1 
ATOM   998  C CG2  . ILE A 1 139 ? 126.789 120.019 115.158 1.00 27.04  ? 139 ILE U CG2  1 
ATOM   999  C CD1  . ILE A 1 139 ? 128.094 121.251 117.576 1.00 21.70  ? 139 ILE U CD1  1 
ATOM   1000 N N    . LEU A 1 140 ? 127.733 116.540 114.489 1.00 22.50  ? 140 LEU U N    1 
ATOM   1001 C CA   . LEU A 1 140 ? 127.689 115.832 113.215 1.00 21.97  ? 140 LEU U CA   1 
ATOM   1002 C C    . LEU A 1 140 ? 126.752 114.633 113.280 1.00 29.41  ? 140 LEU U C    1 
ATOM   1003 O O    . LEU A 1 140 ? 126.030 114.343 112.315 1.00 35.95  ? 140 LEU U O    1 
ATOM   1004 C CB   . LEU A 1 140 ? 129.098 115.389 112.817 1.00 19.85  ? 140 LEU U CB   1 
ATOM   1005 C CG   . LEU A 1 140 ? 129.244 114.656 111.484 1.00 20.20  ? 140 LEU U CG   1 
ATOM   1006 C CD1  . LEU A 1 140 ? 128.899 115.567 110.316 1.00 21.33  ? 140 LEU U CD1  1 
ATOM   1007 C CD2  . LEU A 1 140 ? 130.647 114.094 111.336 1.00 19.46  ? 140 LEU U CD2  1 
ATOM   1008 N N    . PHE A 1 141 ? 126.754 113.918 114.407 1.00 27.72  ? 141 PHE U N    1 
ATOM   1009 C CA   . PHE A 1 141 ? 125.843 112.790 114.576 1.00 24.47  ? 141 PHE U CA   1 
ATOM   1010 C C    . PHE A 1 141 ? 124.391 113.243 114.491 1.00 29.62  ? 141 PHE U C    1 
ATOM   1011 O O    . PHE A 1 141 ? 123.563 112.586 113.849 1.00 32.30  ? 141 PHE U O    1 
ATOM   1012 C CB   . PHE A 1 141 ? 126.111 112.092 115.913 1.00 23.04  ? 141 PHE U CB   1 
ATOM   1013 C CG   . PHE A 1 141 ? 125.293 110.850 116.126 1.00 33.06  ? 141 PHE U CG   1 
ATOM   1014 C CD1  . PHE A 1 141 ? 125.658 109.655 115.529 1.00 26.41  ? 141 PHE U CD1  1 
ATOM   1015 C CD2  . PHE A 1 141 ? 124.157 110.877 116.919 1.00 34.43  ? 141 PHE U CD2  1 
ATOM   1016 C CE1  . PHE A 1 141 ? 124.914 108.511 115.722 1.00 21.72  ? 141 PHE U CE1  1 
ATOM   1017 C CE2  . PHE A 1 141 ? 123.404 109.731 117.109 1.00 30.87  ? 141 PHE U CE2  1 
ATOM   1018 C CZ   . PHE A 1 141 ? 123.783 108.550 116.512 1.00 26.14  ? 141 PHE U CZ   1 
ATOM   1019 N N    . PHE A 1 142 ? 124.064 114.368 115.133 1.00 28.62  ? 142 PHE U N    1 
ATOM   1020 C CA   . PHE A 1 142 ? 122.699 114.883 115.066 1.00 22.89  ? 142 PHE U CA   1 
ATOM   1021 C C    . PHE A 1 142 ? 122.315 115.272 113.640 1.00 30.91  ? 142 PHE U C    1 
ATOM   1022 O O    . PHE A 1 142 ? 121.193 114.996 113.190 1.00 37.28  ? 142 PHE U O    1 
ATOM   1023 C CB   . PHE A 1 142 ? 122.538 116.077 116.006 1.00 26.56  ? 142 PHE U CB   1 
ATOM   1024 C CG   . PHE A 1 142 ? 122.650 115.726 117.462 1.00 28.90  ? 142 PHE U CG   1 
ATOM   1025 C CD1  . PHE A 1 142 ? 122.457 114.424 117.893 1.00 31.62  ? 142 PHE U CD1  1 
ATOM   1026 C CD2  . PHE A 1 142 ? 122.951 116.698 118.400 1.00 30.96  ? 142 PHE U CD2  1 
ATOM   1027 C CE1  . PHE A 1 142 ? 122.559 114.102 119.231 1.00 32.32  ? 142 PHE U CE1  1 
ATOM   1028 C CE2  . PHE A 1 142 ? 123.055 116.382 119.736 1.00 30.30  ? 142 PHE U CE2  1 
ATOM   1029 C CZ   . PHE A 1 142 ? 122.860 115.081 120.155 1.00 28.67  ? 142 PHE U CZ   1 
ATOM   1030 N N    . ASN A 1 143 ? 123.235 115.910 112.909 1.00 33.60  ? 143 ASN U N    1 
ATOM   1031 C CA   . ASN A 1 143 ? 122.936 116.275 111.524 1.00 30.25  ? 143 ASN U CA   1 
ATOM   1032 C C    . ASN A 1 143 ? 122.693 115.041 110.658 1.00 30.75  ? 143 ASN U C    1 
ATOM   1033 O O    . ASN A 1 143 ? 121.753 115.009 109.848 1.00 42.00  ? 143 ASN U O    1 
ATOM   1034 C CB   . ASN A 1 143 ? 124.073 117.118 110.949 1.00 29.51  ? 143 ASN U CB   1 
ATOM   1035 C CG   . ASN A 1 143 ? 124.192 118.471 111.617 1.00 36.49  ? 143 ASN U CG   1 
ATOM   1036 O OD1  . ASN A 1 143 ? 123.231 118.980 112.191 1.00 41.44  ? 143 ASN U OD1  1 
ATOM   1037 N ND2  . ASN A 1 143 ? 125.377 119.062 111.551 1.00 38.04  ? 143 ASN U ND2  1 
ATOM   1038 N N    . LEU A 1 144 ? 123.534 114.014 110.813 1.00 27.71  ? 144 LEU U N    1 
ATOM   1039 C CA   . LEU A 1 144 ? 123.349 112.784 110.049 1.00 29.74  ? 144 LEU U CA   1 
ATOM   1040 C C    . LEU A 1 144 ? 122.035 112.102 110.408 1.00 32.85  ? 144 LEU U C    1 
ATOM   1041 O O    . LEU A 1 144 ? 121.350 111.553 109.533 1.00 39.30  ? 144 LEU U O    1 
ATOM   1042 C CB   . LEU A 1 144 ? 124.527 111.837 110.276 1.00 30.92  ? 144 LEU U CB   1 
ATOM   1043 C CG   . LEU A 1 144 ? 125.908 112.336 109.849 1.00 23.72  ? 144 LEU U CG   1 
ATOM   1044 C CD1  . LEU A 1 144 ? 126.951 111.248 110.038 1.00 23.14  ? 144 LEU U CD1  1 
ATOM   1045 C CD2  . LEU A 1 144 ? 125.887 112.815 108.408 1.00 31.29  ? 144 LEU U CD2  1 
ATOM   1046 N N    . PHE A 1 145 ? 121.666 112.121 111.692 1.00 32.99  ? 145 PHE U N    1 
ATOM   1047 C CA   . PHE A 1 145 ? 120.381 111.566 112.098 1.00 34.43  ? 145 PHE U CA   1 
ATOM   1048 C C    . PHE A 1 145 ? 119.233 112.291 111.416 1.00 33.11  ? 145 PHE U C    1 
ATOM   1049 O O    . PHE A 1 145 ? 118.273 111.662 110.957 1.00 38.42  ? 145 PHE U O    1 
ATOM   1050 C CB   . PHE A 1 145 ? 120.218 111.635 113.617 1.00 35.88  ? 145 PHE U CB   1 
ATOM   1051 C CG   . PHE A 1 145 ? 118.788 111.561 114.071 1.00 41.11  ? 145 PHE U CG   1 
ATOM   1052 C CD1  . PHE A 1 145 ? 118.132 110.342 114.131 1.00 38.89  ? 145 PHE U CD1  1 
ATOM   1053 C CD2  . PHE A 1 145 ? 118.092 112.706 114.422 1.00 36.09  ? 145 PHE U CD2  1 
ATOM   1054 C CE1  . PHE A 1 145 ? 116.817 110.265 114.540 1.00 36.63  ? 145 PHE U CE1  1 
ATOM   1055 C CE2  . PHE A 1 145 ? 116.772 112.635 114.829 1.00 36.25  ? 145 PHE U CE2  1 
ATOM   1056 C CZ   . PHE A 1 145 ? 116.137 111.413 114.891 1.00 37.49  ? 145 PHE U CZ   1 
ATOM   1057 N N    . LEU A 1 146 ? 119.298 113.625 111.364 1.00 33.67  ? 146 LEU U N    1 
ATOM   1058 C CA   . LEU A 1 146 ? 118.231 114.383 110.716 1.00 35.02  ? 146 LEU U CA   1 
ATOM   1059 C C    . LEU A 1 146 ? 118.127 114.041 109.236 1.00 37.38  ? 146 LEU U C    1 
ATOM   1060 O O    . LEU A 1 146 ? 117.021 113.880 108.701 1.00 43.90  ? 146 LEU U O    1 
ATOM   1061 C CB   . LEU A 1 146 ? 118.454 115.882 110.904 1.00 36.60  ? 146 LEU U CB   1 
ATOM   1062 C CG   . LEU A 1 146 ? 117.427 116.795 110.230 1.00 38.39  ? 146 LEU U CG   1 
ATOM   1063 C CD1  . LEU A 1 146 ? 116.014 116.474 110.691 1.00 35.33  ? 146 LEU U CD1  1 
ATOM   1064 C CD2  . LEU A 1 146 ? 117.752 118.255 110.492 1.00 37.37  ? 146 LEU U CD2  1 
ATOM   1065 N N    . GLU A 1 147 ? 119.271 113.927 108.554 1.00 39.33  ? 147 GLU U N    1 
ATOM   1066 C CA   . GLU A 1 147 ? 119.233 113.557 107.140 1.00 36.79  ? 147 GLU U CA   1 
ATOM   1067 C C    . GLU A 1 147 ? 118.615 112.175 106.938 1.00 42.26  ? 147 GLU U C    1 
ATOM   1068 O O    . GLU A 1 147 ? 117.771 111.983 106.048 1.00 48.99  ? 147 GLU U O    1 
ATOM   1069 C CB   . GLU A 1 147 ? 120.643 113.613 106.546 1.00 41.01  ? 147 GLU U CB   1 
ATOM   1070 C CG   . GLU A 1 147 ? 120.785 112.877 105.227 1.00 47.34  ? 147 GLU U CG   1 
ATOM   1071 C CD   . GLU A 1 147 ? 122.222 112.794 104.755 1.00 58.02  ? 147 GLU U CD   1 
ATOM   1072 O OE1  . GLU A 1 147 ? 123.076 113.510 105.316 1.00 59.08  ? 147 GLU U OE1  1 
ATOM   1073 O OE2  . GLU A 1 147 ? 122.495 112.009 103.823 1.00 55.23  ? 147 GLU U OE2  1 
ATOM   1074 N N    . ARG A 1 148 ? 119.011 111.204 107.768 1.00 44.55  ? 148 ARG U N    1 
ATOM   1075 C CA   . ARG A 1 148 ? 118.452 109.860 107.652 1.00 41.65  ? 148 ARG U CA   1 
ATOM   1076 C C    . ARG A 1 148 ? 116.953 109.859 107.921 1.00 40.27  ? 148 ARG U C    1 
ATOM   1077 O O    . ARG A 1 148 ? 116.192 109.150 107.253 1.00 39.39  ? 148 ARG U O    1 
ATOM   1078 C CB   . ARG A 1 148 ? 119.173 108.903 108.603 1.00 36.82  ? 148 ARG U CB   1 
ATOM   1079 C CG   . ARG A 1 148 ? 120.611 108.591 108.209 1.00 32.22  ? 148 ARG U CG   1 
ATOM   1080 C CD   . ARG A 1 148 ? 120.670 107.580 107.074 1.00 34.80  ? 148 ARG U CD   1 
ATOM   1081 N NE   . ARG A 1 148 ? 120.563 108.224 105.771 1.00 42.71  ? 148 ARG U NE   1 
ATOM   1082 C CZ   . ARG A 1 148 ? 120.420 107.573 104.624 1.00 40.27  ? 148 ARG U CZ   1 
ATOM   1083 N NH1  . ARG A 1 148 ? 120.337 106.253 104.581 1.00 40.05  ? 148 ARG U NH1  1 
ATOM   1084 N NH2  . ARG A 1 148 ? 120.345 108.266 103.492 1.00 39.27  ? 148 ARG U NH2  1 
ATOM   1085 N N    . LEU A 1 149 ? 116.513 110.637 108.914 1.00 46.95  ? 149 LEU U N    1 
ATOM   1086 C CA   . LEU A 1 149 ? 115.091 110.716 109.223 1.00 45.22  ? 149 LEU U CA   1 
ATOM   1087 C C    . LEU A 1 149 ? 114.302 111.296 108.059 1.00 42.18  ? 149 LEU U C    1 
ATOM   1088 O O    . LEU A 1 149 ? 113.221 110.797 107.724 1.00 44.37  ? 149 LEU U O    1 
ATOM   1089 C CB   . LEU A 1 149 ? 114.874 111.551 110.487 1.00 42.33  ? 149 LEU U CB   1 
ATOM   1090 C CG   . LEU A 1 149 ? 113.418 111.799 110.882 1.00 40.07  ? 149 LEU U CG   1 
ATOM   1091 C CD1  . LEU A 1 149 ? 112.743 110.498 111.281 1.00 40.43  ? 149 LEU U CD1  1 
ATOM   1092 C CD2  . LEU A 1 149 ? 113.338 112.815 112.009 1.00 41.70  ? 149 LEU U CD2  1 
ATOM   1093 N N    . ILE A 1 150 ? 114.818 112.355 107.433 1.00 41.54  ? 150 ILE U N    1 
ATOM   1094 C CA   . ILE A 1 150 ? 114.124 112.925 106.279 1.00 40.09  ? 150 ILE U CA   1 
ATOM   1095 C C    . ILE A 1 150 ? 114.030 111.905 105.152 1.00 42.60  ? 150 ILE U C    1 
ATOM   1096 O O    . ILE A 1 150 ? 112.977 111.750 104.513 1.00 45.49  ? 150 ILE U O    1 
ATOM   1097 C CB   . ILE A 1 150 ? 114.817 114.223 105.818 1.00 39.46  ? 150 ILE U CB   1 
ATOM   1098 C CG1  . ILE A 1 150 ? 114.678 115.312 106.883 1.00 39.64  ? 150 ILE U CG1  1 
ATOM   1099 C CG2  . ILE A 1 150 ? 114.240 114.698 104.495 1.00 41.05  ? 150 ILE U CG2  1 
ATOM   1100 C CD1  . ILE A 1 150 ? 115.356 116.608 106.514 1.00 40.46  ? 150 ILE U CD1  1 
ATOM   1101 N N    . THR A 1 151 ? 115.125 111.182 104.894 1.00 49.26  ? 151 THR U N    1 
ATOM   1102 C CA   . THR A 1 151 ? 115.112 110.181 103.830 1.00 47.16  ? 151 THR U CA   1 
ATOM   1103 C C    . THR A 1 151 ? 114.090 109.083 104.112 1.00 49.95  ? 151 THR U C    1 
ATOM   1104 O O    . THR A 1 151 ? 113.315 108.695 103.225 1.00 53.23  ? 151 THR U O    1 
ATOM   1105 C CB   . THR A 1 151 ? 116.509 109.585 103.656 1.00 46.21  ? 151 THR U CB   1 
ATOM   1106 O OG1  . THR A 1 151 ? 117.423 110.610 103.251 1.00 53.24  ? 151 THR U OG1  1 
ATOM   1107 C CG2  . THR A 1 151 ? 116.491 108.487 102.605 1.00 44.08  ? 151 THR U CG2  1 
ATOM   1108 N N    . ILE A 1 152 ? 114.064 108.574 105.347 1.00 53.37  ? 152 ILE U N    1 
ATOM   1109 C CA   . ILE A 1 152 ? 113.123 107.506 105.665 1.00 47.55  ? 152 ILE U CA   1 
ATOM   1110 C C    . ILE A 1 152 ? 111.689 108.016 105.610 1.00 51.29  ? 152 ILE U C    1 
ATOM   1111 O O    . ILE A 1 152 ? 110.781 107.286 105.196 1.00 55.21  ? 152 ILE U O    1 
ATOM   1112 C CB   . ILE A 1 152 ? 113.463 106.855 107.023 1.00 48.94  ? 152 ILE U CB   1 
ATOM   1113 C CG1  . ILE A 1 152 ? 112.820 105.469 107.123 1.00 49.42  ? 152 ILE U CG1  1 
ATOM   1114 C CG2  . ILE A 1 152 ? 113.027 107.722 108.193 1.00 45.52  ? 152 ILE U CG2  1 
ATOM   1115 C CD1  . ILE A 1 152 ? 113.336 104.486 106.100 1.00 53.27  ? 152 ILE U CD1  1 
ATOM   1116 N N    . ILE A 1 153 ? 111.454 109.271 106.005 1.00 54.60  ? 153 ILE U N    1 
ATOM   1117 C CA   . ILE A 1 153 ? 110.104 109.828 105.943 1.00 51.32  ? 153 ILE U CA   1 
ATOM   1118 C C    . ILE A 1 153 ? 109.636 109.891 104.499 1.00 52.81  ? 153 ILE U C    1 
ATOM   1119 O O    . ILE A 1 153 ? 108.493 109.525 104.181 1.00 56.28  ? 153 ILE U O    1 
ATOM   1120 C CB   . ILE A 1 153 ? 110.062 111.211 106.623 1.00 49.38  ? 153 ILE U CB   1 
ATOM   1121 C CG1  . ILE A 1 153 ? 109.841 111.053 108.127 1.00 52.56  ? 153 ILE U CG1  1 
ATOM   1122 C CG2  . ILE A 1 153 ? 108.970 112.078 106.012 1.00 48.43  ? 153 ILE U CG2  1 
ATOM   1123 C CD1  . ILE A 1 153 ? 109.575 112.355 108.843 1.00 52.51  ? 153 ILE U CD1  1 
ATOM   1124 N N    . ALA A 1 154 ? 110.511 110.348 103.600 1.00 62.62  ? 154 ALA U N    1 
ATOM   1125 C CA   . ALA A 1 154 ? 110.157 110.380 102.184 1.00 61.53  ? 154 ALA U CA   1 
ATOM   1126 C C    . ALA A 1 154 ? 109.873 108.978 101.658 1.00 59.55  ? 154 ALA U C    1 
ATOM   1127 O O    . ALA A 1 154 ? 108.935 108.779 100.873 1.00 64.01  ? 154 ALA U O    1 
ATOM   1128 C CB   . ALA A 1 154 ? 111.275 111.043 101.377 1.00 60.59  ? 154 ALA U CB   1 
ATOM   1129 N N    . TYR A 1 155 ? 110.678 107.992 102.070 1.00 68.64  ? 155 TYR U N    1 
ATOM   1130 C CA   . TYR A 1 155 ? 110.456 106.625 101.606 1.00 71.01  ? 155 TYR U CA   1 
ATOM   1131 C C    . TYR A 1 155 ? 109.099 106.092 102.066 1.00 71.48  ? 155 TYR U C    1 
ATOM   1132 O O    . TYR A 1 155 ? 108.363 105.485 101.275 1.00 70.91  ? 155 TYR U O    1 
ATOM   1133 C CB   . TYR A 1 155 ? 111.579 105.711 102.094 1.00 70.67  ? 155 TYR U CB   1 
ATOM   1134 C CG   . TYR A 1 155 ? 111.567 104.337 101.463 1.00 72.93  ? 155 TYR U CG   1 
ATOM   1135 C CD1  . TYR A 1 155 ? 112.201 104.102 100.251 1.00 74.35  ? 155 TYR U CD1  1 
ATOM   1136 C CD2  . TYR A 1 155 ? 110.922 103.273 102.079 1.00 73.30  ? 155 TYR U CD2  1 
ATOM   1137 C CE1  . TYR A 1 155 ? 112.193 102.847 99.669  1.00 75.80  ? 155 TYR U CE1  1 
ATOM   1138 C CE2  . TYR A 1 155 ? 110.907 102.017 101.506 1.00 73.79  ? 155 TYR U CE2  1 
ATOM   1139 C CZ   . TYR A 1 155 ? 111.544 101.808 100.303 1.00 76.41  ? 155 TYR U CZ   1 
ATOM   1140 O OH   . TYR A 1 155 ? 111.533 100.559 99.728  1.00 75.59  ? 155 TYR U OH   1 
ATOM   1141 N N    . ILE A 1 156 ? 108.751 106.316 103.337 1.00 69.54  ? 156 ILE U N    1 
ATOM   1142 C CA   . ILE A 1 156 ? 107.454 105.864 103.839 1.00 68.33  ? 156 ILE U CA   1 
ATOM   1143 C C    . ILE A 1 156 ? 106.320 106.563 103.102 1.00 70.12  ? 156 ILE U C    1 
ATOM   1144 O O    . ILE A 1 156 ? 105.307 105.940 102.762 1.00 69.57  ? 156 ILE U O    1 
ATOM   1145 C CB   . ILE A 1 156 ? 107.340 106.058 105.364 1.00 68.06  ? 156 ILE U CB   1 
ATOM   1146 C CG1  . ILE A 1 156 ? 108.570 105.494 106.077 1.00 68.78  ? 156 ILE U CG1  1 
ATOM   1147 C CG2  . ILE A 1 156 ? 106.073 105.405 105.894 1.00 68.48  ? 156 ILE U CG2  1 
ATOM   1148 C CD1  . ILE A 1 156 ? 108.485 105.569 107.587 1.00 68.71  ? 156 ILE U CD1  1 
ATOM   1149 N N    . MET A 1 157 ? 106.452 107.872 102.869 1.00 81.92  ? 157 MET U N    1 
ATOM   1150 C CA   . MET A 1 157 ? 105.397 108.595 102.170 1.00 79.85  ? 157 MET U CA   1 
ATOM   1151 C C    . MET A 1 157 ? 105.200 108.054 100.761 1.00 80.93  ? 157 MET U C    1 
ATOM   1152 O O    . MET A 1 157 ? 104.061 107.849 100.319 1.00 81.75  ? 157 MET U O    1 
ATOM   1153 C CB   . MET A 1 157 ? 105.712 110.090 102.132 1.00 77.36  ? 157 MET U CB   1 
ATOM   1154 C CG   . MET A 1 157 ? 104.981 110.903 103.190 1.00 81.15  ? 157 MET U CG   1 
ATOM   1155 S SD   . MET A 1 157 ? 105.601 112.589 103.341 1.00 90.10  ? 157 MET U SD   1 
ATOM   1156 C CE   . MET A 1 157 ? 105.988 112.963 101.630 1.00 83.38  ? 157 MET U CE   1 
ATOM   1157 N N    . LYS A 1 158 ? 106.299 107.810 100.041 1.00 89.02  ? 158 LYS U N    1 
ATOM   1158 C CA   . LYS A 1 158 ? 106.188 107.265 98.691  1.00 88.73  ? 158 LYS U CA   1 
ATOM   1159 C C    . LYS A 1 158 ? 105.552 105.879 98.705  1.00 89.81  ? 158 LYS U C    1 
ATOM   1160 O O    . LYS A 1 158 ? 104.694 105.574 97.863  1.00 91.36  ? 158 LYS U O    1 
ATOM   1161 C CB   . LYS A 1 158 ? 107.565 107.216 98.029  1.00 88.21  ? 158 LYS U CB   1 
ATOM   1162 C CG   . LYS A 1 158 ? 107.560 106.579 96.646  1.00 89.50  ? 158 LYS U CG   1 
ATOM   1163 C CD   . LYS A 1 158 ? 108.967 106.447 96.089  1.00 90.39  ? 158 LYS U CD   1 
ATOM   1164 C CE   . LYS A 1 158 ? 108.960 105.759 94.733  1.00 87.83  ? 158 LYS U CE   1 
ATOM   1165 N NZ   . LYS A 1 158 ? 108.137 106.504 93.740  1.00 88.09  ? 158 LYS U NZ   1 
ATOM   1166 N N    . SER A 1 159 ? 105.952 105.029 99.652  1.00 91.92  ? 159 SER U N    1 
ATOM   1167 C CA   . SER A 1 159 ? 105.385 103.686 99.721  1.00 92.51  ? 159 SER U CA   1 
ATOM   1168 C C    . SER A 1 159 ? 103.895 103.734 100.036 1.00 93.13  ? 159 SER U C    1 
ATOM   1169 O O    . SER A 1 159 ? 103.102 102.986 99.454  1.00 93.30  ? 159 SER U O    1 
ATOM   1170 C CB   . SER A 1 159 ? 106.126 102.852 100.765 1.00 93.57  ? 159 SER U CB   1 
ATOM   1171 O OG   . SER A 1 159 ? 105.595 101.542 100.845 1.00 93.01  ? 159 SER U OG   1 
ATOM   1172 N N    . CYS A 1 160 ? 103.496 104.619 100.954 1.00 97.35  ? 160 CYS U N    1 
ATOM   1173 C CA   . CYS A 1 160 ? 102.087 104.752 101.300 1.00 98.59  ? 160 CYS U CA   1 
ATOM   1174 C C    . CYS A 1 160 ? 101.273 105.241 100.110 1.00 97.68  ? 160 CYS U C    1 
ATOM   1175 O O    . CYS A 1 160 ? 100.170 104.742 99.854  1.00 98.29  ? 160 CYS U O    1 
ATOM   1176 C CB   . CYS A 1 160 ? 101.921 105.698 102.490 1.00 98.37  ? 160 CYS U CB   1 
ATOM   1177 S SG   . CYS A 1 160 ? 100.217 105.894 103.057 1.00 97.38  ? 160 CYS U SG   1 
ATOM   1178 N N    . HIS A 1 161 ? 101.798 106.224 99.371  1.00 101.32 ? 161 HIS U N    1 
ATOM   1179 C CA   . HIS A 1 161 ? 101.092 106.704 98.184  1.00 103.29 ? 161 HIS U CA   1 
ATOM   1180 C C    . HIS A 1 161 ? 100.957 105.601 97.144  1.00 103.57 ? 161 HIS U C    1 
ATOM   1181 O O    . HIS A 1 161 ? 99.892  105.436 96.535  1.00 103.11 ? 161 HIS U O    1 
ATOM   1182 C CB   . HIS A 1 161 ? 101.811 107.917 97.595  1.00 103.01 ? 161 HIS U CB   1 
ATOM   1183 C CG   . HIS A 1 161 ? 101.170 108.453 96.351  1.00 103.32 ? 161 HIS U CG   1 
ATOM   1184 N ND1  . HIS A 1 161 ? 101.425 107.932 95.098  1.00 102.84 ? 161 HIS U ND1  1 
ATOM   1185 C CD2  . HIS A 1 161 ? 100.284 109.457 96.167  1.00 103.01 ? 161 HIS U CD2  1 
ATOM   1186 C CE1  . HIS A 1 161 ? 100.725 108.595 94.199  1.00 103.25 ? 161 HIS U CE1  1 
ATOM   1187 N NE2  . HIS A 1 161 ? 100.023 109.525 94.820  1.00 104.81 ? 161 HIS U NE2  1 
ATOM   1188 N N    . GLN A 1 162 ? 102.026 104.830 96.928  1.00 107.37 ? 162 GLN U N    1 
ATOM   1189 C CA   . GLN A 1 162 ? 101.970 103.754 95.943  1.00 107.30 ? 162 GLN U CA   1 
ATOM   1190 C C    . GLN A 1 162 ? 100.956 102.694 96.351  1.00 107.71 ? 162 GLN U C    1 
ATOM   1191 O O    . GLN A 1 162 ? 100.218 102.174 95.505  1.00 107.41 ? 162 GLN U O    1 
ATOM   1192 C CB   . GLN A 1 162 ? 103.354 103.131 95.760  1.00 107.01 ? 162 GLN U CB   1 
ATOM   1193 C CG   . GLN A 1 162 ? 103.521 102.376 94.450  1.00 106.96 ? 162 GLN U CG   1 
ATOM   1194 C CD   . GLN A 1 162 ? 103.060 100.931 94.543  1.00 108.30 ? 162 GLN U CD   1 
ATOM   1195 O OE1  . GLN A 1 162 ? 102.944 100.375 95.634  1.00 109.15 ? 162 GLN U OE1  1 
ATOM   1196 N NE2  . GLN A 1 162 ? 102.791 100.322 93.395  1.00 107.26 ? 162 GLN U NE2  1 
ATOM   1197 N N    . ALA A 1 188 ? 113.159 110.316 95.697  1.00 91.13  ? 188 ALA U N    1 
ATOM   1198 C CA   . ALA A 1 188 ? 113.324 111.112 94.486  1.00 94.01  ? 188 ALA U CA   1 
ATOM   1199 C C    . ALA A 1 188 ? 112.650 112.472 94.631  1.00 96.22  ? 188 ALA U C    1 
ATOM   1200 O O    . ALA A 1 188 ? 113.109 113.327 95.388  1.00 94.14  ? 188 ALA U O    1 
ATOM   1201 C CB   . ALA A 1 188 ? 112.766 110.368 93.280  1.00 91.82  ? 188 ALA U CB   1 
ATOM   1202 N N    . GLY A 1 189 ? 111.553 112.665 93.901  1.00 95.47  ? 189 GLY U N    1 
ATOM   1203 C CA   . GLY A 1 189 ? 110.838 113.926 93.931  1.00 93.28  ? 189 GLY U CA   1 
ATOM   1204 C C    . GLY A 1 189 ? 109.698 113.946 94.927  1.00 92.89  ? 189 GLY U C    1 
ATOM   1205 O O    . GLY A 1 189 ? 108.804 114.796 94.839  1.00 90.95  ? 189 GLY U O    1 
ATOM   1206 N N    . TRP A 1 190 ? 109.714 113.015 95.878  1.00 90.26  ? 190 TRP U N    1 
ATOM   1207 C CA   . TRP A 1 190 ? 108.660 112.892 96.876  1.00 88.11  ? 190 TRP U CA   1 
ATOM   1208 C C    . TRP A 1 190 ? 109.075 113.434 98.242  1.00 86.77  ? 190 TRP U C    1 
ATOM   1209 O O    . TRP A 1 190 ? 108.483 113.056 99.256  1.00 89.42  ? 190 TRP U O    1 
ATOM   1210 C CB   . TRP A 1 190 ? 108.218 111.432 97.004  1.00 88.65  ? 190 TRP U CB   1 
ATOM   1211 C CG   . TRP A 1 190 ? 107.694 110.847 95.729  1.00 90.14  ? 190 TRP U CG   1 
ATOM   1212 C CD1  . TRP A 1 190 ? 108.427 110.357 94.686  1.00 89.80  ? 190 TRP U CD1  1 
ATOM   1213 C CD2  . TRP A 1 190 ? 106.318 110.688 95.360  1.00 91.15  ? 190 TRP U CD2  1 
ATOM   1214 N NE1  . TRP A 1 190 ? 107.593 109.905 93.693  1.00 89.97  ? 190 TRP U NE1  1 
ATOM   1215 C CE2  . TRP A 1 190 ? 106.293 110.098 94.082  1.00 91.05  ? 190 TRP U CE2  1 
ATOM   1216 C CE3  . TRP A 1 190 ? 105.104 110.991 95.988  1.00 90.24  ? 190 TRP U CE3  1 
ATOM   1217 C CZ2  . TRP A 1 190 ? 105.104 109.802 93.419  1.00 90.40  ? 190 TRP U CZ2  1 
ATOM   1218 C CZ3  . TRP A 1 190 ? 103.926 110.697 95.328  1.00 89.66  ? 190 TRP U CZ3  1 
ATOM   1219 C CH2  . TRP A 1 190 ? 103.933 110.107 94.057  1.00 90.59  ? 190 TRP U CH2  1 
ATOM   1220 N N    . LYS A 1 191 ? 110.081 114.301 98.285  1.00 76.21  ? 191 LYS U N    1 
ATOM   1221 C CA   . LYS A 1 191 ? 110.530 114.845 99.557  1.00 78.68  ? 191 LYS U CA   1 
ATOM   1222 C C    . LYS A 1 191 ? 109.436 115.716 100.174 1.00 77.02  ? 191 LYS U C    1 
ATOM   1223 O O    . LYS A 1 191 ? 108.798 116.504 99.470  1.00 77.94  ? 191 LYS U O    1 
ATOM   1224 C CB   . LYS A 1 191 ? 111.808 115.666 99.368  1.00 79.37  ? 191 LYS U CB   1 
ATOM   1225 C CG   . LYS A 1 191 ? 113.043 114.830 99.092  1.00 81.48  ? 191 LYS U CG   1 
ATOM   1226 C CD   . LYS A 1 191 ? 114.289 115.692 99.004  1.00 81.02  ? 191 LYS U CD   1 
ATOM   1227 C CE   . LYS A 1 191 ? 115.531 114.846 98.760  1.00 79.36  ? 191 LYS U CE   1 
ATOM   1228 N NZ   . LYS A 1 191 ? 116.757 115.679 98.623  1.00 79.78  ? 191 LYS U NZ   1 
ATOM   1229 N N    . PRO A 1 192 ? 109.197 115.595 101.476 1.00 66.02  ? 192 PRO U N    1 
ATOM   1230 C CA   . PRO A 1 192 ? 108.140 116.393 102.105 1.00 66.83  ? 192 PRO U CA   1 
ATOM   1231 C C    . PRO A 1 192 ? 108.542 117.853 102.241 1.00 66.12  ? 192 PRO U C    1 
ATOM   1232 O O    . PRO A 1 192 ? 109.716 118.220 102.157 1.00 66.37  ? 192 PRO U O    1 
ATOM   1233 C CB   . PRO A 1 192 ? 107.973 115.733 103.475 1.00 66.48  ? 192 PRO U CB   1 
ATOM   1234 C CG   . PRO A 1 192 ? 109.319 115.165 103.769 1.00 63.51  ? 192 PRO U CG   1 
ATOM   1235 C CD   . PRO A 1 192 ? 109.877 114.717 102.442 1.00 63.09  ? 192 PRO U CD   1 
ATOM   1236 N N    . SER A 1 193 ? 107.530 118.695 102.446 1.00 56.10  ? 193 SER U N    1 
ATOM   1237 C CA   . SER A 1 193 ? 107.770 120.110 102.677 1.00 52.27  ? 193 SER U CA   1 
ATOM   1238 C C    . SER A 1 193 ? 108.270 120.346 104.099 1.00 54.32  ? 193 SER U C    1 
ATOM   1239 O O    . SER A 1 193 ? 108.260 119.453 104.951 1.00 58.82  ? 193 SER U O    1 
ATOM   1240 C CB   . SER A 1 193 ? 106.498 120.916 102.419 1.00 54.59  ? 193 SER U CB   1 
ATOM   1241 O OG   . SER A 1 193 ? 105.457 120.525 103.298 1.00 57.37  ? 193 SER U OG   1 
ATOM   1242 N N    . VAL A 1 194 ? 108.710 121.578 104.356 1.00 46.31  ? 194 VAL U N    1 
ATOM   1243 C CA   . VAL A 1 194 ? 109.224 121.925 105.677 1.00 47.30  ? 194 VAL U CA   1 
ATOM   1244 C C    . VAL A 1 194 ? 108.107 121.906 106.715 1.00 50.58  ? 194 VAL U C    1 
ATOM   1245 O O    . VAL A 1 194 ? 108.319 121.519 107.870 1.00 53.92  ? 194 VAL U O    1 
ATOM   1246 C CB   . VAL A 1 194 ? 109.928 123.295 105.622 1.00 48.24  ? 194 VAL U CB   1 
ATOM   1247 C CG1  . VAL A 1 194 ? 110.553 123.632 106.963 1.00 48.06  ? 194 VAL U CG1  1 
ATOM   1248 C CG2  . VAL A 1 194 ? 110.977 123.305 104.521 1.00 48.75  ? 194 VAL U CG2  1 
ATOM   1249 N N    . TYR A 1 195 ? 106.902 122.331 106.323 1.00 51.32  ? 195 TYR U N    1 
ATOM   1250 C CA   . TYR A 1 195 ? 105.776 122.384 107.250 1.00 51.84  ? 195 TYR U CA   1 
ATOM   1251 C C    . TYR A 1 195 ? 105.425 120.994 107.774 1.00 57.73  ? 195 TYR U C    1 
ATOM   1252 O O    . TYR A 1 195 ? 105.210 120.800 108.978 1.00 60.18  ? 195 TYR U O    1 
ATOM   1253 C CB   . TYR A 1 195 ? 104.577 123.031 106.556 1.00 51.81  ? 195 TYR U CB   1 
ATOM   1254 C CG   . TYR A 1 195 ? 103.389 123.301 107.450 1.00 59.12  ? 195 TYR U CG   1 
ATOM   1255 C CD1  . TYR A 1 195 ? 103.456 124.244 108.464 1.00 58.77  ? 195 TYR U CD1  1 
ATOM   1256 C CD2  . TYR A 1 195 ? 102.187 122.625 107.264 1.00 57.98  ? 195 TYR U CD2  1 
ATOM   1257 C CE1  . TYR A 1 195 ? 102.371 124.499 109.280 1.00 61.24  ? 195 TYR U CE1  1 
ATOM   1258 C CE2  . TYR A 1 195 ? 101.096 122.874 108.072 1.00 54.06  ? 195 TYR U CE2  1 
ATOM   1259 C CZ   . TYR A 1 195 ? 101.193 123.810 109.079 1.00 59.76  ? 195 TYR U CZ   1 
ATOM   1260 O OH   . TYR A 1 195 ? 100.109 124.063 109.887 1.00 62.48  ? 195 TYR U OH   1 
ATOM   1261 N N    . TYR A 1 196 ? 105.365 120.006 106.875 1.00 55.33  ? 196 TYR U N    1 
ATOM   1262 C CA   . TYR A 1 196 ? 105.021 118.649 107.284 1.00 53.68  ? 196 TYR U CA   1 
ATOM   1263 C C    . TYR A 1 196 ? 106.108 118.045 108.163 1.00 53.91  ? 196 TYR U C    1 
ATOM   1264 O O    . TYR A 1 196 ? 105.807 117.333 109.130 1.00 60.26  ? 196 TYR U O    1 
ATOM   1265 C CB   . TYR A 1 196 ? 104.777 117.777 106.051 1.00 54.27  ? 196 TYR U CB   1 
ATOM   1266 C CG   . TYR A 1 196 ? 103.515 118.132 105.295 1.00 61.24  ? 196 TYR U CG   1 
ATOM   1267 C CD1  . TYR A 1 196 ? 102.467 118.790 105.924 1.00 59.05  ? 196 TYR U CD1  1 
ATOM   1268 C CD2  . TYR A 1 196 ? 103.375 117.811 103.952 1.00 61.33  ? 196 TYR U CD2  1 
ATOM   1269 C CE1  . TYR A 1 196 ? 101.317 119.120 105.235 1.00 59.05  ? 196 TYR U CE1  1 
ATOM   1270 C CE2  . TYR A 1 196 ? 102.229 118.134 103.256 1.00 60.07  ? 196 TYR U CE2  1 
ATOM   1271 C CZ   . TYR A 1 196 ? 101.202 118.788 103.904 1.00 62.05  ? 196 TYR U CZ   1 
ATOM   1272 O OH   . TYR A 1 196 ? 100.055 119.115 103.215 1.00 61.90  ? 196 TYR U OH   1 
ATOM   1273 N N    . VAL A 1 197 ? 107.376 118.314 107.845 1.00 44.66  ? 197 VAL U N    1 
ATOM   1274 C CA   . VAL A 1 197 ? 108.470 117.838 108.684 1.00 42.90  ? 197 VAL U CA   1 
ATOM   1275 C C    . VAL A 1 197 ? 108.373 118.449 110.073 1.00 44.77  ? 197 VAL U C    1 
ATOM   1276 O O    . VAL A 1 197 ? 108.595 117.771 111.083 1.00 48.75  ? 197 VAL U O    1 
ATOM   1277 C CB   . VAL A 1 197 ? 109.828 118.135 108.021 1.00 44.00  ? 197 VAL U CB   1 
ATOM   1278 C CG1  . VAL A 1 197 ? 110.968 117.745 108.949 1.00 44.16  ? 197 VAL U CG1  1 
ATOM   1279 C CG2  . VAL A 1 197 ? 109.947 117.386 106.709 1.00 47.83  ? 197 VAL U CG2  1 
ATOM   1280 N N    . MET A 1 198 ? 108.034 119.738 110.149 1.00 49.12  ? 198 MET U N    1 
ATOM   1281 C CA   . MET A 1 198 ? 107.874 120.382 111.448 1.00 46.24  ? 198 MET U CA   1 
ATOM   1282 C C    . MET A 1 198 ? 106.737 119.749 112.241 1.00 48.90  ? 198 MET U C    1 
ATOM   1283 O O    . MET A 1 198 ? 106.872 119.504 113.446 1.00 55.04  ? 198 MET U O    1 
ATOM   1284 C CB   . MET A 1 198 ? 107.633 121.881 111.266 1.00 50.56  ? 198 MET U CB   1 
ATOM   1285 C CG   . MET A 1 198 ? 107.999 122.715 112.481 1.00 54.79  ? 198 MET U CG   1 
ATOM   1286 S SD   . MET A 1 198 ? 106.936 124.154 112.697 1.00 68.66  ? 198 MET U SD   1 
ATOM   1287 C CE   . MET A 1 198 ? 105.319 123.411 112.499 1.00 53.05  ? 198 MET U CE   1 
ATOM   1288 N N    . LEU A 1 199 ? 105.607 119.482 111.582 1.00 44.14  ? 199 LEU U N    1 
ATOM   1289 C CA   . LEU A 1 199 ? 104.484 118.851 112.273 1.00 45.41  ? 199 LEU U CA   1 
ATOM   1290 C C    . LEU A 1 199 ? 104.851 117.459 112.775 1.00 47.09  ? 199 LEU U C    1 
ATOM   1291 O O    . LEU A 1 199 ? 104.517 117.087 113.911 1.00 49.54  ? 199 LEU U O    1 
ATOM   1292 C CB   . LEU A 1 199 ? 103.265 118.784 111.353 1.00 41.74  ? 199 LEU U CB   1 
ATOM   1293 C CG   . LEU A 1 199 ? 102.661 120.118 110.907 1.00 46.96  ? 199 LEU U CG   1 
ATOM   1294 C CD1  . LEU A 1 199 ? 101.373 119.892 110.135 1.00 48.61  ? 199 LEU U CD1  1 
ATOM   1295 C CD2  . LEU A 1 199 ? 102.419 121.023 112.104 1.00 45.77  ? 199 LEU U CD2  1 
ATOM   1296 N N    . ILE A 1 200 ? 105.545 116.676 111.947 1.00 44.70  ? 200 ILE U N    1 
ATOM   1297 C CA   . ILE A 1 200 ? 105.934 115.325 112.342 1.00 43.51  ? 200 ILE U CA   1 
ATOM   1298 C C    . ILE A 1 200 ? 106.927 115.368 113.496 1.00 45.22  ? 200 ILE U C    1 
ATOM   1299 O O    . ILE A 1 200 ? 106.845 114.561 114.432 1.00 47.74  ? 200 ILE U O    1 
ATOM   1300 C CB   . ILE A 1 200 ? 106.502 114.559 111.130 1.00 39.17  ? 200 ILE U CB   1 
ATOM   1301 C CG1  . ILE A 1 200 ? 105.382 114.223 110.144 1.00 44.52  ? 200 ILE U CG1  1 
ATOM   1302 C CG2  . ILE A 1 200 ? 107.212 113.291 111.572 1.00 38.11  ? 200 ILE U CG2  1 
ATOM   1303 C CD1  . ILE A 1 200 ? 105.861 113.513 108.904 1.00 42.40  ? 200 ILE U CD1  1 
ATOM   1304 N N    . LEU A 1 201 ? 107.878 116.302 113.453 1.00 39.28  ? 201 LEU U N    1 
ATOM   1305 C CA   . LEU A 1 201 ? 108.832 116.441 114.549 1.00 34.64  ? 201 LEU U CA   1 
ATOM   1306 C C    . LEU A 1 201 ? 108.135 116.858 115.836 1.00 41.16  ? 201 LEU U C    1 
ATOM   1307 O O    . LEU A 1 201 ? 108.486 116.378 116.919 1.00 44.92  ? 201 LEU U O    1 
ATOM   1308 C CB   . LEU A 1 201 ? 109.922 117.442 114.173 1.00 36.31  ? 201 LEU U CB   1 
ATOM   1309 C CG   . LEU A 1 201 ? 111.010 116.923 113.232 1.00 36.79  ? 201 LEU U CG   1 
ATOM   1310 C CD1  . LEU A 1 201 ? 111.912 118.055 112.774 1.00 38.71  ? 201 LEU U CD1  1 
ATOM   1311 C CD2  . LEU A 1 201 ? 111.816 115.822 113.898 1.00 37.55  ? 201 LEU U CD2  1 
ATOM   1312 N N    . CYS A 1 202 ? 107.145 117.750 115.742 1.00 45.99  ? 202 CYS U N    1 
ATOM   1313 C CA   . CYS A 1 202 ? 106.392 118.143 116.931 1.00 41.79  ? 202 CYS U CA   1 
ATOM   1314 C C    . CYS A 1 202 ? 105.650 116.952 117.523 1.00 43.46  ? 202 CYS U C    1 
ATOM   1315 O O    . CYS A 1 202 ? 105.660 116.738 118.743 1.00 44.18  ? 202 CYS U O    1 
ATOM   1316 C CB   . CYS A 1 202 ? 105.415 119.268 116.582 1.00 37.76  ? 202 CYS U CB   1 
ATOM   1317 S SG   . CYS A 1 202 ? 106.175 120.880 116.306 1.00 58.80  ? 202 CYS U SG   1 
ATOM   1318 N N    . THR A 1 203 ? 104.996 116.163 116.665 1.00 39.83  ? 203 THR U N    1 
ATOM   1319 C CA   . THR A 1 203 ? 104.274 114.988 117.148 1.00 36.31  ? 203 THR U CA   1 
ATOM   1320 C C    . THR A 1 203 ? 105.223 113.980 117.788 1.00 43.48  ? 203 THR U C    1 
ATOM   1321 O O    . THR A 1 203 ? 104.922 113.424 118.853 1.00 42.26  ? 203 THR U O    1 
ATOM   1322 C CB   . THR A 1 203 ? 103.503 114.337 115.996 1.00 37.55  ? 203 THR U CB   1 
ATOM   1323 O OG1  . THR A 1 203 ? 102.615 115.297 115.412 1.00 48.26  ? 203 THR U OG1  1 
ATOM   1324 C CG2  . THR A 1 203 ? 102.693 113.152 116.498 1.00 39.94  ? 203 THR U CG2  1 
ATOM   1325 N N    . ALA A 1 204 ? 106.377 113.741 117.160 1.00 47.49  ? 204 ALA U N    1 
ATOM   1326 C CA   . ALA A 1 204 ? 107.353 112.813 117.722 1.00 36.69  ? 204 ALA U CA   1 
ATOM   1327 C C    . ALA A 1 204 ? 107.877 113.306 119.063 1.00 40.74  ? 204 ALA U C    1 
ATOM   1328 O O    . ALA A 1 204 ? 108.039 112.520 120.002 1.00 48.75  ? 204 ALA U O    1 
ATOM   1329 C CB   . ALA A 1 204 ? 108.507 112.606 116.740 1.00 38.87  ? 204 ALA U CB   1 
ATOM   1330 N N    . SER A 1 205 ? 108.155 114.609 119.170 1.00 42.19  ? 205 SER U N    1 
ATOM   1331 C CA   . SER A 1 205 ? 108.647 115.162 120.425 1.00 40.99  ? 205 SER U CA   1 
ATOM   1332 C C    . SER A 1 205 ? 107.608 115.011 121.527 1.00 40.14  ? 205 SER U C    1 
ATOM   1333 O O    . SER A 1 205 ? 107.942 114.630 122.655 1.00 39.58  ? 205 SER U O    1 
ATOM   1334 C CB   . SER A 1 205 ? 109.027 116.630 120.237 1.00 36.02  ? 205 SER U CB   1 
ATOM   1335 O OG   . SER A 1 205 ? 109.982 116.781 119.203 1.00 42.75  ? 205 SER U OG   1 
ATOM   1336 N N    . ILE A 1 206 ? 106.343 115.297 121.213 1.00 41.06  ? 206 ILE U N    1 
ATOM   1337 C CA   . ILE A 1 206 ? 105.280 115.160 122.208 1.00 38.26  ? 206 ILE U CA   1 
ATOM   1338 C C    . ILE A 1 206 ? 105.147 113.707 122.650 1.00 40.49  ? 206 ILE U C    1 
ATOM   1339 O O    . ILE A 1 206 ? 105.031 113.414 123.846 1.00 44.14  ? 206 ILE U O    1 
ATOM   1340 C CB   . ILE A 1 206 ? 103.953 115.707 121.648 1.00 42.71  ? 206 ILE U CB   1 
ATOM   1341 C CG1  . ILE A 1 206 ? 104.019 117.229 121.517 1.00 43.44  ? 206 ILE U CG1  1 
ATOM   1342 C CG2  . ILE A 1 206 ? 102.786 115.301 122.535 1.00 40.98  ? 206 ILE U CG2  1 
ATOM   1343 C CD1  . ILE A 1 206 ? 102.738 117.855 121.010 1.00 43.37  ? 206 ILE U CD1  1 
ATOM   1344 N N    . LEU A 1 207 ? 105.158 112.776 121.692 1.00 40.81  ? 207 LEU U N    1 
ATOM   1345 C CA   . LEU A 1 207 ? 105.018 111.365 122.036 1.00 39.45  ? 207 LEU U CA   1 
ATOM   1346 C C    . LEU A 1 207 ? 106.182 110.876 122.888 1.00 42.24  ? 207 LEU U C    1 
ATOM   1347 O O    . LEU A 1 207 ? 105.979 110.154 123.870 1.00 42.83  ? 207 LEU U O    1 
ATOM   1348 C CB   . LEU A 1 207 ? 104.893 110.521 120.768 1.00 43.80  ? 207 LEU U CB   1 
ATOM   1349 C CG   . LEU A 1 207 ? 103.551 110.586 120.035 1.00 48.71  ? 207 LEU U CG   1 
ATOM   1350 C CD1  . LEU A 1 207 ? 103.561 109.678 118.818 1.00 43.39  ? 207 LEU U CD1  1 
ATOM   1351 C CD2  . LEU A 1 207 ? 102.411 110.216 120.971 1.00 43.41  ? 207 LEU U CD2  1 
ATOM   1352 N N    . ILE A 1 208 ? 107.410 111.266 122.531 1.00 37.79  ? 208 ILE U N    1 
ATOM   1353 C CA   . ILE A 1 208 ? 108.577 110.840 123.301 1.00 37.41  ? 208 ILE U CA   1 
ATOM   1354 C C    . ILE A 1 208 ? 108.524 111.422 124.706 1.00 40.63  ? 208 ILE U C    1 
ATOM   1355 O O    . ILE A 1 208 ? 108.816 110.731 125.691 1.00 41.81  ? 208 ILE U O    1 
ATOM   1356 C CB   . ILE A 1 208 ? 109.876 111.226 122.568 1.00 37.44  ? 208 ILE U CB   1 
ATOM   1357 C CG1  . ILE A 1 208 ? 110.062 110.350 121.327 1.00 39.83  ? 208 ILE U CG1  1 
ATOM   1358 C CG2  . ILE A 1 208 ? 111.080 111.096 123.489 1.00 37.97  ? 208 ILE U CG2  1 
ATOM   1359 C CD1  . ILE A 1 208 ? 111.342 110.625 120.577 1.00 37.03  ? 208 ILE U CD1  1 
ATOM   1360 N N    . SER A 1 209 ? 108.147 112.698 124.821 1.00 45.15  ? 209 SER U N    1 
ATOM   1361 C CA   . SER A 1 209 ? 108.051 113.326 126.132 1.00 34.86  ? 209 SER U CA   1 
ATOM   1362 C C    . SER A 1 209 ? 107.007 112.633 126.997 1.00 33.42  ? 209 SER U C    1 
ATOM   1363 O O    . SER A 1 209 ? 107.251 112.365 128.178 1.00 40.45  ? 209 SER U O    1 
ATOM   1364 C CB   . SER A 1 209 ? 107.725 114.809 125.980 1.00 33.52  ? 209 SER U CB   1 
ATOM   1365 O OG   . SER A 1 209 ? 108.878 115.551 125.629 1.00 43.73  ? 209 SER U OG   1 
ATOM   1366 N N    . CYS A 1 210 ? 105.836 112.331 126.427 1.00 38.57  ? 210 CYS U N    1 
ATOM   1367 C CA   . CYS A 1 210 ? 104.790 111.677 127.209 1.00 36.12  ? 210 CYS U CA   1 
ATOM   1368 C C    . CYS A 1 210 ? 105.188 110.261 127.610 1.00 38.54  ? 210 CYS U C    1 
ATOM   1369 O O    . CYS A 1 210 ? 104.913 109.830 128.734 1.00 37.99  ? 210 CYS U O    1 
ATOM   1370 C CB   . CYS A 1 210 ? 103.481 111.667 126.418 1.00 36.32  ? 210 CYS U CB   1 
ATOM   1371 S SG   . CYS A 1 210 ? 102.692 113.285 126.261 1.00 48.25  ? 210 CYS U SG   1 
ATOM   1372 N N    . CYS A 1 211 ? 105.844 109.523 126.708 1.00 44.99  ? 211 CYS U N    1 
ATOM   1373 C CA   . CYS A 1 211 ? 106.284 108.173 127.046 1.00 42.89  ? 211 CYS U CA   1 
ATOM   1374 C C    . CYS A 1 211 ? 107.343 108.197 128.141 1.00 41.91  ? 211 CYS U C    1 
ATOM   1375 O O    . CYS A 1 211 ? 107.314 107.365 129.056 1.00 46.46  ? 211 CYS U O    1 
ATOM   1376 C CB   . CYS A 1 211 ? 106.808 107.461 125.801 1.00 46.03  ? 211 CYS U CB   1 
ATOM   1377 S SG   . CYS A 1 211 ? 105.529 106.654 124.815 1.00 61.23  ? 211 CYS U SG   1 
ATOM   1378 N N    . ALA A 1 212 ? 108.286 109.137 128.062 1.00 36.73  ? 212 ALA U N    1 
ATOM   1379 C CA   . ALA A 1 212 ? 109.292 109.259 129.109 1.00 33.46  ? 212 ALA U CA   1 
ATOM   1380 C C    . ALA A 1 212 ? 108.655 109.669 130.430 1.00 37.98  ? 212 ALA U C    1 
ATOM   1381 O O    . ALA A 1 212 ? 109.057 109.185 131.494 1.00 33.27  ? 212 ALA U O    1 
ATOM   1382 C CB   . ALA A 1 212 ? 110.368 110.264 128.695 1.00 28.61  ? 212 ALA U CB   1 
ATOM   1383 N N    . SER A 1 213 ? 107.666 110.568 130.380 1.00 38.11  ? 213 SER U N    1 
ATOM   1384 C CA   . SER A 1 213 ? 106.992 111.043 131.578 1.00 25.21  ? 213 SER U CA   1 
ATOM   1385 C C    . SER A 1 213 ? 106.070 109.993 132.185 1.00 33.01  ? 213 SER U C    1 
ATOM   1386 O O    . SER A 1 213 ? 105.693 110.128 133.352 1.00 33.80  ? 213 SER U O    1 
ATOM   1387 C CB   . SER A 1 213 ? 106.199 112.311 131.265 1.00 31.20  ? 213 SER U CB   1 
ATOM   1388 O OG   . SER A 1 213 ? 107.047 113.338 130.793 1.00 41.35  ? 213 SER U OG   1 
ATOM   1389 N N    . ALA A 1 214 ? 105.688 108.967 131.420 1.00 40.78  ? 214 ALA U N    1 
ATOM   1390 C CA   . ALA A 1 214 ? 104.917 107.877 132.009 1.00 33.07  ? 214 ALA U CA   1 
ATOM   1391 C C    . ALA A 1 214 ? 105.694 107.216 133.139 1.00 37.51  ? 214 ALA U C    1 
ATOM   1392 O O    . ALA A 1 214 ? 105.132 106.912 134.195 1.00 41.94  ? 214 ALA U O    1 
ATOM   1393 C CB   . ALA A 1 214 ? 104.545 106.852 130.939 1.00 34.86  ? 214 ALA U CB   1 
ATOM   1394 N N    . MET A 1 215 ? 106.988 106.988 132.936 1.00 41.91  ? 215 MET U N    1 
ATOM   1395 C CA   . MET A 1 215 ? 107.893 106.727 134.043 1.00 42.32  ? 215 MET U CA   1 
ATOM   1396 C C    . MET A 1 215 ? 108.516 108.053 134.483 1.00 48.69  ? 215 MET U C    1 
ATOM   1397 O O    . MET A 1 215 ? 108.142 109.123 134.002 1.00 57.69  ? 215 MET U O    1 
ATOM   1398 C CB   . MET A 1 215 ? 108.911 105.657 133.647 1.00 38.79  ? 215 MET U CB   1 
ATOM   1399 C CG   . MET A 1 215 ? 109.958 106.070 132.626 1.00 47.88  ? 215 MET U CG   1 
ATOM   1400 S SD   . MET A 1 215 ? 111.298 104.861 132.548 1.00 56.94  ? 215 MET U SD   1 
ATOM   1401 C CE   . MET A 1 215 ? 112.724 105.917 132.327 1.00 40.75  ? 215 MET U CE   1 
ATOM   1402 N N    . TYR A 1 216 ? 109.370 107.974 135.503 1.00 32.37  ? 216 TYR U N    1 
ATOM   1403 C CA   . TYR A 1 216 ? 109.926 109.202 136.128 1.00 37.48  ? 216 TYR U CA   1 
ATOM   1404 C C    . TYR A 1 216 ? 108.890 109.739 137.113 1.00 40.15  ? 216 TYR U C    1 
ATOM   1405 O O    . TYR A 1 216 ? 109.267 110.508 138.006 1.00 47.86  ? 216 TYR U O    1 
ATOM   1406 C CB   . TYR A 1 216 ? 110.192 110.349 135.148 1.00 27.88  ? 216 TYR U CB   1 
ATOM   1407 C CG   . TYR A 1 216 ? 111.375 110.249 134.219 1.00 31.56  ? 216 TYR U CG   1 
ATOM   1408 C CD1  . TYR A 1 216 ? 112.405 109.351 134.438 1.00 38.71  ? 216 TYR U CD1  1 
ATOM   1409 C CD2  . TYR A 1 216 ? 111.449 111.061 133.100 1.00 32.45  ? 216 TYR U CD2  1 
ATOM   1410 C CE1  . TYR A 1 216 ? 113.485 109.278 133.574 1.00 37.31  ? 216 TYR U CE1  1 
ATOM   1411 C CE2  . TYR A 1 216 ? 112.514 110.993 132.224 1.00 33.95  ? 216 TYR U CE2  1 
ATOM   1412 C CZ   . TYR A 1 216 ? 113.538 110.099 132.464 1.00 37.48  ? 216 TYR U CZ   1 
ATOM   1413 O OH   . TYR A 1 216 ? 114.595 110.035 131.593 1.00 38.93  ? 216 TYR U OH   1 
ATOM   1414 N N    . THR A 1 217 ? 107.636 109.300 136.991 1.00 36.00  ? 217 THR U N    1 
ATOM   1415 C CA   . THR A 1 217 ? 106.568 109.844 137.819 1.00 33.97  ? 217 THR U CA   1 
ATOM   1416 C C    . THR A 1 217 ? 106.387 108.944 139.038 1.00 40.30  ? 217 THR U C    1 
ATOM   1417 O O    . THR A 1 217 ? 106.372 109.451 140.167 1.00 44.95  ? 217 THR U O    1 
ATOM   1418 C CB   . THR A 1 217 ? 105.253 109.992 137.036 1.00 37.72  ? 217 THR U CB   1 
ATOM   1419 O OG1  . THR A 1 217 ? 105.443 110.883 135.929 1.00 37.82  ? 217 THR U OG1  1 
ATOM   1420 C CG2  . THR A 1 217 ? 104.121 110.488 137.922 1.00 38.27  ? 217 THR U CG2  1 
ATOM   1421 N N    . PRO A 1 218 ? 106.248 107.612 138.884 1.00 38.24  ? 218 PRO U N    1 
ATOM   1422 C CA   . PRO A 1 218 ? 106.163 106.765 140.078 1.00 38.84  ? 218 PRO U CA   1 
ATOM   1423 C C    . PRO A 1 218 ? 107.516 106.317 140.606 1.00 40.14  ? 218 PRO U C    1 
ATOM   1424 O O    . PRO A 1 218 ? 107.678 106.082 141.807 1.00 43.86  ? 218 PRO U O    1 
ATOM   1425 C CB   . PRO A 1 218 ? 105.333 105.573 139.597 1.00 38.62  ? 218 PRO U CB   1 
ATOM   1426 C CG   . PRO A 1 218 ? 105.698 105.438 138.169 1.00 37.61  ? 218 PRO U CG   1 
ATOM   1427 C CD   . PRO A 1 218 ? 106.006 106.819 137.656 1.00 31.84  ? 218 PRO U CD   1 
ATOM   1428 N N    . ILE A 1 219 ? 108.499 106.195 139.710 1.00 37.17  ? 219 ILE U N    1 
ATOM   1429 C CA   . ILE A 1 219 ? 109.818 105.725 140.116 1.00 37.78  ? 219 ILE U CA   1 
ATOM   1430 C C    . ILE A 1 219 ? 110.594 106.743 140.952 1.00 40.18  ? 219 ILE U C    1 
ATOM   1431 O O    . ILE A 1 219 ? 111.325 106.352 141.870 1.00 46.61  ? 219 ILE U O    1 
ATOM   1432 C CB   . ILE A 1 219 ? 110.620 105.310 138.864 1.00 36.12  ? 219 ILE U CB   1 
ATOM   1433 C CG1  . ILE A 1 219 ? 109.971 104.109 138.173 1.00 38.67  ? 219 ILE U CG1  1 
ATOM   1434 C CG2  . ILE A 1 219 ? 112.058 104.973 139.222 1.00 32.41  ? 219 ILE U CG2  1 
ATOM   1435 C CD1  . ILE A 1 219 ? 109.418 103.067 139.118 1.00 37.81  ? 219 ILE U CD1  1 
ATOM   1436 N N    . GLU A 1 220 ? 110.376 108.030 140.706 1.00 40.18  ? 220 GLU U N    1 
ATOM   1437 C CA   . GLU A 1 220 ? 111.127 109.092 141.412 1.00 40.33  ? 220 GLU U CA   1 
ATOM   1438 C C    . GLU A 1 220 ? 110.305 110.085 142.241 1.00 43.63  ? 220 GLU U C    1 
ATOM   1439 O O    . GLU A 1 220 ? 110.888 111.111 142.518 1.00 52.26  ? 220 GLU U O    1 
ATOM   1440 C CB   . GLU A 1 220 ? 111.818 109.936 140.352 1.00 34.74  ? 220 GLU U CB   1 
ATOM   1441 C CG   . GLU A 1 220 ? 112.500 109.113 139.296 1.00 40.54  ? 220 GLU U CG   1 
ATOM   1442 C CD   . GLU A 1 220 ? 113.741 109.803 138.780 1.00 45.11  ? 220 GLU U CD   1 
ATOM   1443 O OE1  . GLU A 1 220 ? 113.618 110.953 138.363 1.00 58.12  ? 220 GLU U OE1  1 
ATOM   1444 O OE2  . GLU A 1 220 ? 114.813 109.193 138.808 1.00 44.20  ? 220 GLU U OE2  1 
ATOM   1445 N N    . GLY A 1 221 ? 109.095 109.804 142.737 1.00 44.06  ? 221 GLY U N    1 
ATOM   1446 C CA   . GLY A 1 221 ? 108.295 110.821 143.409 1.00 43.22  ? 221 GLY U CA   1 
ATOM   1447 C C    . GLY A 1 221 ? 107.970 112.124 142.698 1.00 45.83  ? 221 GLY U C    1 
ATOM   1448 O O    . GLY A 1 221 ? 107.821 113.158 143.361 1.00 51.92  ? 221 GLY U O    1 
ATOM   1449 N N    . TRP A 1 222 ? 107.850 112.116 141.376 1.00 33.94  ? 222 TRP U N    1 
ATOM   1450 C CA   . TRP A 1 222 ? 107.656 113.326 140.587 1.00 33.95  ? 222 TRP U CA   1 
ATOM   1451 C C    . TRP A 1 222 ? 106.246 113.386 140.019 1.00 43.06  ? 222 TRP U C    1 
ATOM   1452 O O    . TRP A 1 222 ? 105.622 112.360 139.750 1.00 50.21  ? 222 TRP U O    1 
ATOM   1453 C CB   . TRP A 1 222 ? 108.659 113.401 139.428 1.00 25.85  ? 222 TRP U CB   1 
ATOM   1454 C CG   . TRP A 1 222 ? 110.055 113.800 139.799 1.00 34.61  ? 222 TRP U CG   1 
ATOM   1455 C CD1  . TRP A 1 222 ? 110.540 114.057 141.047 1.00 39.45  ? 222 TRP U CD1  1 
ATOM   1456 C CD2  . TRP A 1 222 ? 111.164 113.937 138.903 1.00 34.84  ? 222 TRP U CD2  1 
ATOM   1457 N NE1  . TRP A 1 222 ? 111.875 114.366 140.981 1.00 34.94  ? 222 TRP U NE1  1 
ATOM   1458 C CE2  . TRP A 1 222 ? 112.284 114.300 139.677 1.00 30.98  ? 222 TRP U CE2  1 
ATOM   1459 C CE3  . TRP A 1 222 ? 111.319 113.797 137.519 1.00 35.22  ? 222 TRP U CE3  1 
ATOM   1460 C CZ2  . TRP A 1 222 ? 113.540 114.525 139.114 1.00 32.11  ? 222 TRP U CZ2  1 
ATOM   1461 C CZ3  . TRP A 1 222 ? 112.564 114.021 136.964 1.00 29.64  ? 222 TRP U CZ3  1 
ATOM   1462 C CH2  . TRP A 1 222 ? 113.659 114.379 137.760 1.00 27.95  ? 222 TRP U CH2  1 
ATOM   1463 N N    . SER A 1 223 ? 105.734 114.604 139.880 1.00 36.14  ? 223 SER U N    1 
ATOM   1464 C CA   . SER A 1 223 ? 104.437 114.825 139.262 1.00 29.24  ? 223 SER U CA   1 
ATOM   1465 C C    . SER A 1 223 ? 104.596 114.892 137.744 1.00 38.17  ? 223 SER U C    1 
ATOM   1466 O O    . SER A 1 223 ? 105.671 115.189 137.220 1.00 46.77  ? 223 SER U O    1 
ATOM   1467 C CB   . SER A 1 223 ? 103.793 116.106 139.788 1.00 37.17  ? 223 SER U CB   1 
ATOM   1468 O OG   . SER A 1 223 ? 104.442 117.257 139.277 1.00 44.26  ? 223 SER U OG   1 
ATOM   1469 N N    . TYR A 1 224 ? 103.505 114.584 137.039 1.00 35.01  ? 224 TYR U N    1 
ATOM   1470 C CA   . TYR A 1 224 ? 103.548 114.524 135.580 1.00 34.28  ? 224 TYR U CA   1 
ATOM   1471 C C    . TYR A 1 224 ? 103.980 115.849 134.958 1.00 38.90  ? 224 TYR U C    1 
ATOM   1472 O O    . TYR A 1 224 ? 104.761 115.865 133.998 1.00 40.58  ? 224 TYR U O    1 
ATOM   1473 C CB   . TYR A 1 224 ? 102.178 114.103 135.046 1.00 35.09  ? 224 TYR U CB   1 
ATOM   1474 C CG   . TYR A 1 224 ? 102.197 113.579 133.629 1.00 42.56  ? 224 TYR U CG   1 
ATOM   1475 C CD1  . TYR A 1 224 ? 102.708 112.319 133.346 1.00 41.74  ? 224 TYR U CD1  1 
ATOM   1476 C CD2  . TYR A 1 224 ? 101.710 114.341 132.578 1.00 42.28  ? 224 TYR U CD2  1 
ATOM   1477 C CE1  . TYR A 1 224 ? 102.731 111.833 132.056 1.00 38.81  ? 224 TYR U CE1  1 
ATOM   1478 C CE2  . TYR A 1 224 ? 101.729 113.862 131.283 1.00 38.74  ? 224 TYR U CE2  1 
ATOM   1479 C CZ   . TYR A 1 224 ? 102.241 112.609 131.029 1.00 38.84  ? 224 TYR U CZ   1 
ATOM   1480 O OH   . TYR A 1 224 ? 102.263 112.127 129.741 1.00 42.92  ? 224 TYR U OH   1 
ATOM   1481 N N    . PHE A 1 225 ? 103.486 116.972 135.485 1.00 38.38  ? 225 PHE U N    1 
ATOM   1482 C CA   . PHE A 1 225 ? 103.915 118.270 134.972 1.00 38.43  ? 225 PHE U CA   1 
ATOM   1483 C C    . PHE A 1 225 ? 105.402 118.506 135.214 1.00 40.55  ? 225 PHE U C    1 
ATOM   1484 O O    . PHE A 1 225 ? 106.104 119.050 134.352 1.00 44.53  ? 225 PHE U O    1 
ATOM   1485 C CB   . PHE A 1 225 ? 103.083 119.390 135.603 1.00 39.92  ? 225 PHE U CB   1 
ATOM   1486 C CG   . PHE A 1 225 ? 103.448 120.760 135.110 1.00 45.35  ? 225 PHE U CG   1 
ATOM   1487 C CD1  . PHE A 1 225 ? 103.400 121.053 133.758 1.00 40.86  ? 225 PHE U CD1  1 
ATOM   1488 C CD2  . PHE A 1 225 ? 103.848 121.746 135.992 1.00 41.24  ? 225 PHE U CD2  1 
ATOM   1489 C CE1  . PHE A 1 225 ? 103.742 122.308 133.294 1.00 37.29  ? 225 PHE U CE1  1 
ATOM   1490 C CE2  . PHE A 1 225 ? 104.189 123.004 135.534 1.00 40.63  ? 225 PHE U CE2  1 
ATOM   1491 C CZ   . PHE A 1 225 ? 104.136 123.285 134.183 1.00 41.49  ? 225 PHE U CZ   1 
ATOM   1492 N N    . ASP A 1 226 ? 105.901 118.090 136.380 1.00 31.58  ? 226 ASP U N    1 
ATOM   1493 C CA   . ASP A 1 226 ? 107.328 118.201 136.664 1.00 33.29  ? 226 ASP U CA   1 
ATOM   1494 C C    . ASP A 1 226 ? 108.145 117.339 135.711 1.00 39.70  ? 226 ASP U C    1 
ATOM   1495 O O    . ASP A 1 226 ? 109.228 117.741 135.270 1.00 44.66  ? 226 ASP U O    1 
ATOM   1496 C CB   . ASP A 1 226 ? 107.610 117.816 138.117 1.00 36.27  ? 226 ASP U CB   1 
ATOM   1497 C CG   . ASP A 1 226 ? 107.330 118.947 139.082 1.00 42.99  ? 226 ASP U CG   1 
ATOM   1498 O OD1  . ASP A 1 226 ? 106.911 120.033 138.629 1.00 44.85  ? 226 ASP U OD1  1 
ATOM   1499 O OD2  . ASP A 1 226 ? 107.525 118.748 140.301 1.00 43.28  ? 226 ASP U OD2  1 
ATOM   1500 N N    . SER A 1 227 ? 107.642 116.145 135.385 1.00 34.31  ? 227 SER U N    1 
ATOM   1501 C CA   . SER A 1 227 ? 108.340 115.286 134.437 1.00 30.91  ? 227 SER U CA   1 
ATOM   1502 C C    . SER A 1 227 ? 108.387 115.914 133.050 1.00 34.03  ? 227 SER U C    1 
ATOM   1503 O O    . SER A 1 227 ? 109.421 115.861 132.376 1.00 35.43  ? 227 SER U O    1 
ATOM   1504 C CB   . SER A 1 227 ? 107.668 113.913 134.381 1.00 37.01  ? 227 SER U CB   1 
ATOM   1505 O OG   . SER A 1 227 ? 107.667 113.297 135.655 1.00 40.08  ? 227 SER U OG   1 
ATOM   1506 N N    . LEU A 1 228 ? 107.281 116.515 132.604 1.00 32.17  ? 228 LEU U N    1 
ATOM   1507 C CA   . LEU A 1 228 ? 107.291 117.191 131.311 1.00 29.52  ? 228 LEU U CA   1 
ATOM   1508 C C    . LEU A 1 228 ? 108.253 118.377 131.308 1.00 29.10  ? 228 LEU U C    1 
ATOM   1509 O O    . LEU A 1 228 ? 108.970 118.605 130.323 1.00 36.96  ? 228 LEU U O    1 
ATOM   1510 C CB   . LEU A 1 228 ? 105.877 117.651 130.951 1.00 32.44  ? 228 LEU U CB   1 
ATOM   1511 C CG   . LEU A 1 228 ? 104.856 116.559 130.625 1.00 35.71  ? 228 LEU U CG   1 
ATOM   1512 C CD1  . LEU A 1 228 ? 103.480 117.161 130.405 1.00 31.49  ? 228 LEU U CD1  1 
ATOM   1513 C CD2  . LEU A 1 228 ? 105.285 115.762 129.405 1.00 36.11  ? 228 LEU U CD2  1 
ATOM   1514 N N    . TYR A 1 229 ? 108.289 119.137 132.405 1.00 21.50  ? 229 TYR U N    1 
ATOM   1515 C CA   . TYR A 1 229 ? 109.222 120.257 132.510 1.00 23.19  ? 229 TYR U CA   1 
ATOM   1516 C C    . TYR A 1 229 ? 110.671 119.780 132.463 1.00 25.79  ? 229 TYR U C    1 
ATOM   1517 O O    . TYR A 1 229 ? 111.507 120.371 131.765 1.00 25.39  ? 229 TYR U O    1 
ATOM   1518 C CB   . TYR A 1 229 ? 108.933 121.041 133.794 1.00 21.53  ? 229 TYR U CB   1 
ATOM   1519 C CG   . TYR A 1 229 ? 109.929 122.132 134.125 1.00 27.48  ? 229 TYR U CG   1 
ATOM   1520 C CD1  . TYR A 1 229 ? 109.963 123.314 133.397 1.00 22.63  ? 229 TYR U CD1  1 
ATOM   1521 C CD2  . TYR A 1 229 ? 110.809 121.989 135.187 1.00 30.75  ? 229 TYR U CD2  1 
ATOM   1522 C CE1  . TYR A 1 229 ? 110.867 124.310 133.704 1.00 20.26  ? 229 TYR U CE1  1 
ATOM   1523 C CE2  . TYR A 1 229 ? 111.711 122.982 135.500 1.00 31.26  ? 229 TYR U CE2  1 
ATOM   1524 C CZ   . TYR A 1 229 ? 111.738 124.141 134.758 1.00 26.33  ? 229 TYR U CZ   1 
ATOM   1525 O OH   . TYR A 1 229 ? 112.639 125.128 135.075 1.00 28.18  ? 229 TYR U OH   1 
ATOM   1526 N N    . PHE A 1 230 ? 110.980 118.697 133.182 1.00 24.37  ? 230 PHE U N    1 
ATOM   1527 C CA   . PHE A 1 230 ? 112.324 118.128 133.145 1.00 22.57  ? 230 PHE U CA   1 
ATOM   1528 C C    . PHE A 1 230 ? 112.680 117.645 131.746 1.00 29.80  ? 230 PHE U C    1 
ATOM   1529 O O    . PHE A 1 230 ? 113.810 117.835 131.283 1.00 30.36  ? 230 PHE U O    1 
ATOM   1530 C CB   . PHE A 1 230 ? 112.438 116.980 134.148 1.00 26.26  ? 230 PHE U CB   1 
ATOM   1531 C CG   . PHE A 1 230 ? 113.622 116.082 133.911 1.00 33.76  ? 230 PHE U CG   1 
ATOM   1532 C CD1  . PHE A 1 230 ? 114.897 116.482 134.272 1.00 30.15  ? 230 PHE U CD1  1 
ATOM   1533 C CD2  . PHE A 1 230 ? 113.459 114.840 133.318 1.00 30.47  ? 230 PHE U CD2  1 
ATOM   1534 C CE1  . PHE A 1 230 ? 115.985 115.662 134.053 1.00 25.46  ? 230 PHE U CE1  1 
ATOM   1535 C CE2  . PHE A 1 230 ? 114.546 114.017 133.091 1.00 25.00  ? 230 PHE U CE2  1 
ATOM   1536 C CZ   . PHE A 1 230 ? 115.808 114.426 133.460 1.00 22.65  ? 230 PHE U CZ   1 
ATOM   1537 N N    . CYS A 1 231 ? 111.727 117.004 131.064 1.00 31.72  ? 231 CYS U N    1 
ATOM   1538 C CA   . CYS A 1 231 ? 111.977 116.527 129.708 1.00 19.34  ? 231 CYS U CA   1 
ATOM   1539 C C    . CYS A 1 231 ? 112.302 117.683 128.777 1.00 23.62  ? 231 CYS U C    1 
ATOM   1540 O O    . CYS A 1 231 ? 113.241 117.600 127.977 1.00 32.90  ? 231 CYS U O    1 
ATOM   1541 C CB   . CYS A 1 231 ? 110.773 115.738 129.192 1.00 16.35  ? 231 CYS U CB   1 
ATOM   1542 S SG   . CYS A 1 231 ? 110.593 114.088 129.911 1.00 38.24  ? 231 CYS U SG   1 
ATOM   1543 N N    . PHE A 1 232 ? 111.540 118.779 128.868 1.00 26.83  ? 232 PHE U N    1 
ATOM   1544 C CA   . PHE A 1 232 ? 111.822 119.929 128.016 1.00 21.99  ? 232 PHE U CA   1 
ATOM   1545 C C    . PHE A 1 232 ? 113.183 120.535 128.335 1.00 17.80  ? 232 PHE U C    1 
ATOM   1546 O O    . PHE A 1 232 ? 113.934 120.903 127.423 1.00 26.37  ? 232 PHE U O    1 
ATOM   1547 C CB   . PHE A 1 232 ? 110.733 120.991 128.148 1.00 20.80  ? 232 PHE U CB   1 
ATOM   1548 C CG   . PHE A 1 232 ? 111.005 122.227 127.334 1.00 29.29  ? 232 PHE U CG   1 
ATOM   1549 C CD1  . PHE A 1 232 ? 110.774 122.237 125.970 1.00 27.02  ? 232 PHE U CD1  1 
ATOM   1550 C CD2  . PHE A 1 232 ? 111.522 123.366 127.929 1.00 28.93  ? 232 PHE U CD2  1 
ATOM   1551 C CE1  . PHE A 1 232 ? 111.039 123.366 125.217 1.00 20.05  ? 232 PHE U CE1  1 
ATOM   1552 C CE2  . PHE A 1 232 ? 111.790 124.495 127.183 1.00 28.83  ? 232 PHE U CE2  1 
ATOM   1553 C CZ   . PHE A 1 232 ? 111.547 124.495 125.825 1.00 22.79  ? 232 PHE U CZ   1 
ATOM   1554 N N    . VAL A 1 233 ? 113.519 120.655 129.622 1.00 22.71  ? 233 VAL U N    1 
ATOM   1555 C CA   . VAL A 1 233 ? 114.784 121.293 129.987 1.00 22.73  ? 233 VAL U CA   1 
ATOM   1556 C C    . VAL A 1 233 ? 115.970 120.445 129.542 1.00 24.47  ? 233 VAL U C    1 
ATOM   1557 O O    . VAL A 1 233 ? 116.982 120.969 129.063 1.00 19.67  ? 233 VAL U O    1 
ATOM   1558 C CB   . VAL A 1 233 ? 114.825 121.580 131.501 1.00 22.34  ? 233 VAL U CB   1 
ATOM   1559 C CG1  . VAL A 1 233 ? 116.207 122.058 131.918 1.00 16.90  ? 233 VAL U CG1  1 
ATOM   1560 C CG2  . VAL A 1 233 ? 113.783 122.620 131.867 1.00 24.10  ? 233 VAL U CG2  1 
ATOM   1561 N N    . ALA A 1 234 ? 115.869 119.121 129.684 1.00 27.16  ? 234 ALA U N    1 
ATOM   1562 C CA   . ALA A 1 234 ? 116.980 118.252 129.300 1.00 19.20  ? 234 ALA U CA   1 
ATOM   1563 C C    . ALA A 1 234 ? 117.104 118.122 127.785 1.00 25.79  ? 234 ALA U C    1 
ATOM   1564 O O    . ALA A 1 234 ? 118.215 118.146 127.248 1.00 29.40  ? 234 ALA U O    1 
ATOM   1565 C CB   . ALA A 1 234 ? 116.815 116.876 129.942 1.00 17.75  ? 234 ALA U CB   1 
ATOM   1566 N N    . PHE A 1 235 ? 115.977 117.983 127.083 1.00 27.82  ? 235 PHE U N    1 
ATOM   1567 C CA   . PHE A 1 235 ? 116.022 117.726 125.644 1.00 17.33  ? 235 PHE U CA   1 
ATOM   1568 C C    . PHE A 1 235 ? 116.565 118.922 124.872 1.00 22.79  ? 235 PHE U C    1 
ATOM   1569 O O    . PHE A 1 235 ? 117.261 118.751 123.866 1.00 24.12  ? 235 PHE U O    1 
ATOM   1570 C CB   . PHE A 1 235 ? 114.636 117.340 125.129 1.00 15.17  ? 235 PHE U CB   1 
ATOM   1571 C CG   . PHE A 1 235 ? 114.155 115.996 125.602 1.00 24.61  ? 235 PHE U CG   1 
ATOM   1572 C CD1  . PHE A 1 235 ? 114.996 115.144 126.300 1.00 26.65  ? 235 PHE U CD1  1 
ATOM   1573 C CD2  . PHE A 1 235 ? 112.858 115.583 125.343 1.00 24.11  ? 235 PHE U CD2  1 
ATOM   1574 C CE1  . PHE A 1 235 ? 114.553 113.912 126.733 1.00 24.93  ? 235 PHE U CE1  1 
ATOM   1575 C CE2  . PHE A 1 235 ? 112.410 114.350 125.774 1.00 17.76  ? 235 PHE U CE2  1 
ATOM   1576 C CZ   . PHE A 1 235 ? 113.255 113.514 126.471 1.00 23.05  ? 235 PHE U CZ   1 
ATOM   1577 N N    . SER A 1 236 ? 116.253 120.139 125.314 1.00 24.23  ? 236 SER U N    1 
ATOM   1578 C CA   . SER A 1 236 ? 116.735 121.346 124.657 1.00 24.09  ? 236 SER U CA   1 
ATOM   1579 C C    . SER A 1 236 ? 118.187 121.670 124.978 1.00 30.44  ? 236 SER U C    1 
ATOM   1580 O O    . SER A 1 236 ? 118.699 122.679 124.477 1.00 28.25  ? 236 SER U O    1 
ATOM   1581 C CB   . SER A 1 236 ? 115.850 122.537 125.035 1.00 21.96  ? 236 SER U CB   1 
ATOM   1582 O OG   . SER A 1 236 ? 115.836 122.737 126.439 1.00 24.48  ? 236 SER U OG   1 
ATOM   1583 N N    . THR A 1 237 ? 118.855 120.848 125.791 1.00 31.51  ? 237 THR U N    1 
ATOM   1584 C CA   . THR A 1 237 ? 120.253 121.046 126.188 1.00 21.39  ? 237 THR U CA   1 
ATOM   1585 C C    . THR A 1 237 ? 120.462 122.360 126.943 1.00 25.58  ? 237 THR U C    1 
ATOM   1586 O O    . THR A 1 237 ? 121.547 122.942 126.903 1.00 34.37  ? 237 THR U O    1 
ATOM   1587 C CB   . THR A 1 237 ? 121.208 120.970 124.989 1.00 25.15  ? 237 THR U CB   1 
ATOM   1588 O OG1  . THR A 1 237 ? 120.979 122.080 124.113 1.00 31.81  ? 237 THR U OG1  1 
ATOM   1589 C CG2  . THR A 1 237 ? 120.999 119.675 124.223 1.00 24.84  ? 237 THR U CG2  1 
ATOM   1590 N N    . ILE A 1 238 ? 119.429 122.824 127.644 1.00 21.19  ? 238 ILE U N    1 
ATOM   1591 C CA   . ILE A 1 238 ? 119.599 123.942 128.570 1.00 20.74  ? 238 ILE U CA   1 
ATOM   1592 C C    . ILE A 1 238 ? 120.260 123.464 129.857 1.00 27.65  ? 238 ILE U C    1 
ATOM   1593 O O    . ILE A 1 238 ? 121.280 124.012 130.290 1.00 39.51  ? 238 ILE U O    1 
ATOM   1594 C CB   . ILE A 1 238 ? 118.249 124.628 128.837 1.00 24.31  ? 238 ILE U CB   1 
ATOM   1595 C CG1  . ILE A 1 238 ? 117.767 125.352 127.577 1.00 25.45  ? 238 ILE U CG1  1 
ATOM   1596 C CG2  . ILE A 1 238 ? 118.362 125.597 130.000 1.00 16.16  ? 238 ILE U CG2  1 
ATOM   1597 C CD1  . ILE A 1 238 ? 116.470 126.111 127.758 1.00 21.09  ? 238 ILE U CD1  1 
ATOM   1598 N N    . GLY A 1 239 ? 119.682 122.447 130.490 1.00 26.36  ? 239 GLY U N    1 
ATOM   1599 C CA   . GLY A 1 239 ? 120.293 121.795 131.633 1.00 14.73  ? 239 GLY U CA   1 
ATOM   1600 C C    . GLY A 1 239 ? 120.472 122.604 132.900 1.00 26.55  ? 239 GLY U C    1 
ATOM   1601 O O    . GLY A 1 239 ? 121.574 122.641 133.453 1.00 38.12  ? 239 GLY U O    1 
ATOM   1602 N N    . PHE A 1 240 ? 119.406 123.278 133.349 1.00 27.31  ? 240 PHE U N    1 
ATOM   1603 C CA   . PHE A 1 240 ? 119.455 124.042 134.596 1.00 20.68  ? 240 PHE U CA   1 
ATOM   1604 C C    . PHE A 1 240 ? 120.117 123.254 135.721 1.00 27.38  ? 240 PHE U C    1 
ATOM   1605 O O    . PHE A 1 240 ? 120.967 123.782 136.447 1.00 34.19  ? 240 PHE U O    1 
ATOM   1606 C CB   . PHE A 1 240 ? 118.045 124.474 135.008 1.00 21.52  ? 240 PHE U CB   1 
ATOM   1607 C CG   . PHE A 1 240 ? 117.470 125.573 134.163 1.00 24.56  ? 240 PHE U CG   1 
ATOM   1608 C CD1  . PHE A 1 240 ? 118.286 126.565 133.645 1.00 27.84  ? 240 PHE U CD1  1 
ATOM   1609 C CD2  . PHE A 1 240 ? 116.109 125.625 133.903 1.00 22.86  ? 240 PHE U CD2  1 
ATOM   1610 C CE1  . PHE A 1 240 ? 117.758 127.583 132.875 1.00 28.66  ? 240 PHE U CE1  1 
ATOM   1611 C CE2  . PHE A 1 240 ? 115.577 126.640 133.132 1.00 26.18  ? 240 PHE U CE2  1 
ATOM   1612 C CZ   . PHE A 1 240 ? 116.400 127.621 132.619 1.00 23.28  ? 240 PHE U CZ   1 
ATOM   1613 N N    . GLY A 1 241 ? 119.736 121.987 135.884 1.00 32.55  ? 241 GLY U N    1 
ATOM   1614 C CA   . GLY A 1 241 ? 120.279 121.160 136.940 1.00 31.26  ? 241 GLY U CA   1 
ATOM   1615 C C    . GLY A 1 241 ? 119.433 121.061 138.190 1.00 35.49  ? 241 GLY U C    1 
ATOM   1616 O O    . GLY A 1 241 ? 119.809 120.332 139.115 1.00 39.69  ? 241 GLY U O    1 
ATOM   1617 N N    . ASP A 1 242 ? 118.314 121.788 138.256 1.00 33.48  ? 242 ASP U N    1 
ATOM   1618 C CA   . ASP A 1 242 ? 117.421 121.685 139.408 1.00 31.17  ? 242 ASP U CA   1 
ATOM   1619 C C    . ASP A 1 242 ? 116.801 120.294 139.518 1.00 38.09  ? 242 ASP U C    1 
ATOM   1620 O O    . ASP A 1 242 ? 116.656 119.760 140.622 1.00 42.30  ? 242 ASP U O    1 
ATOM   1621 C CB   . ASP A 1 242 ? 116.333 122.757 139.325 1.00 31.07  ? 242 ASP U CB   1 
ATOM   1622 C CG   . ASP A 1 242 ? 115.711 122.855 137.947 1.00 44.04  ? 242 ASP U CG   1 
ATOM   1623 O OD1  . ASP A 1 242 ? 116.327 122.375 136.974 1.00 47.36  ? 242 ASP U OD1  1 
ATOM   1624 O OD2  . ASP A 1 242 ? 114.599 123.416 137.836 1.00 44.37  ? 242 ASP U OD2  1 
ATOM   1625 N N    . LEU A 1 243 ? 116.413 119.699 138.392 1.00 39.02  ? 243 LEU U N    1 
ATOM   1626 C CA   . LEU A 1 243 ? 115.905 118.331 138.348 1.00 33.22  ? 243 LEU U CA   1 
ATOM   1627 C C    . LEU A 1 243 ? 116.843 117.468 137.516 1.00 34.79  ? 243 LEU U C    1 
ATOM   1628 O O    . LEU A 1 243 ? 116.997 117.703 136.312 1.00 43.76  ? 243 LEU U O    1 
ATOM   1629 C CB   . LEU A 1 243 ? 114.487 118.278 137.779 1.00 34.78  ? 243 LEU U CB   1 
ATOM   1630 C CG   . LEU A 1 243 ? 113.362 118.881 138.619 1.00 35.11  ? 243 LEU U CG   1 
ATOM   1631 C CD1  . LEU A 1 243 ? 112.047 118.830 137.861 1.00 35.00  ? 243 LEU U CD1  1 
ATOM   1632 C CD2  . LEU A 1 243 ? 113.242 118.153 139.944 1.00 34.56  ? 243 LEU U CD2  1 
ATOM   1633 N N    . VAL A 1 244 ? 117.477 116.486 138.152 1.00 33.15  ? 244 VAL U N    1 
ATOM   1634 C CA   . VAL A 1 244 ? 118.330 115.523 137.469 1.00 31.50  ? 244 VAL U CA   1 
ATOM   1635 C C    . VAL A 1 244 ? 117.843 114.117 137.795 1.00 35.52  ? 244 VAL U C    1 
ATOM   1636 O O    . VAL A 1 244 ? 117.528 113.807 138.947 1.00 35.30  ? 244 VAL U O    1 
ATOM   1637 C CB   . VAL A 1 244 ? 119.815 115.687 137.860 1.00 28.64  ? 244 VAL U CB   1 
ATOM   1638 C CG1  . VAL A 1 244 ? 120.694 114.768 137.023 1.00 28.24  ? 244 VAL U CG1  1 
ATOM   1639 C CG2  . VAL A 1 244 ? 120.252 117.136 137.703 1.00 34.71  ? 244 VAL U CG2  1 
ATOM   1640 N N    . SER A 1 245 ? 117.772 113.273 136.769 1.00 38.72  ? 245 SER U N    1 
ATOM   1641 C CA   . SER A 1 245 ? 117.215 111.932 136.870 1.00 28.60  ? 245 SER U CA   1 
ATOM   1642 C C    . SER A 1 245 ? 118.285 110.889 137.179 1.00 36.01  ? 245 SER U C    1 
ATOM   1643 O O    . SER A 1 245 ? 119.468 111.074 136.878 1.00 41.40  ? 245 SER U O    1 
ATOM   1644 C CB   . SER A 1 245 ? 116.492 111.561 135.575 1.00 28.68  ? 245 SER U CB   1 
ATOM   1645 O OG   . SER A 1 245 ? 115.899 110.278 135.673 1.00 41.73  ? 245 SER U OG   1 
ATOM   1646 N N    . SER A 1 246 ? 117.847 109.788 137.798 1.00 32.79  ? 246 SER U N    1 
ATOM   1647 C CA   . SER A 1 246 ? 118.656 108.573 137.963 1.00 28.84  ? 246 SER U CA   1 
ATOM   1648 C C    . SER A 1 246 ? 119.848 108.780 138.902 1.00 30.01  ? 246 SER U C    1 
ATOM   1649 O O    . SER A 1 246 ? 120.998 108.507 138.546 1.00 38.68  ? 246 SER U O    1 
ATOM   1650 C CB   . SER A 1 246 ? 119.115 108.033 136.606 1.00 33.98  ? 246 SER U CB   1 
ATOM   1651 O OG   . SER A 1 246 ? 119.998 106.937 136.764 1.00 38.55  ? 246 SER U OG   1 
ATOM   1652 N N    . GLN A 1 247 ? 119.573 109.260 140.115 1.00 34.04  ? 247 GLN U N    1 
ATOM   1653 C CA   . GLN A 1 247 ? 120.578 109.221 141.183 1.00 37.06  ? 247 GLN U CA   1 
ATOM   1654 C C    . GLN A 1 247 ? 119.843 109.100 142.519 1.00 35.58  ? 247 GLN U C    1 
ATOM   1655 O O    . GLN A 1 247 ? 119.468 110.101 143.130 1.00 40.80  ? 247 GLN U O    1 
ATOM   1656 C CB   . GLN A 1 247 ? 121.483 110.441 141.149 1.00 36.23  ? 247 GLN U CB   1 
ATOM   1657 C CG   . GLN A 1 247 ? 120.795 111.718 140.725 1.00 31.37  ? 247 GLN U CG   1 
ATOM   1658 C CD   . GLN A 1 247 ? 121.716 112.607 139.921 1.00 36.02  ? 247 GLN U CD   1 
ATOM   1659 O OE1  . GLN A 1 247 ? 122.486 112.125 139.090 1.00 32.91  ? 247 GLN U OE1  1 
ATOM   1660 N NE2  . GLN A 1 247 ? 121.649 113.907 140.167 1.00 42.66  ? 247 GLN U NE2  1 
ATOM   1661 N N    . ASN A 1 248 ? 119.651 107.853 142.963 1.00 35.48  ? 248 ASN U N    1 
ATOM   1662 C CA   . ASN A 1 248 ? 118.998 107.571 144.234 1.00 36.05  ? 248 ASN U CA   1 
ATOM   1663 C C    . ASN A 1 248 ? 119.622 106.372 144.935 1.00 43.34  ? 248 ASN U C    1 
ATOM   1664 O O    . ASN A 1 248 ? 118.923 105.639 145.644 1.00 53.44  ? 248 ASN U O    1 
ATOM   1665 C CB   . ASN A 1 248 ? 117.500 107.337 144.046 1.00 39.45  ? 248 ASN U CB   1 
ATOM   1666 C CG   . ASN A 1 248 ? 116.681 108.591 144.263 1.00 41.36  ? 248 ASN U CG   1 
ATOM   1667 O OD1  . ASN A 1 248 ? 117.144 109.548 144.878 1.00 44.20  ? 248 ASN U OD1  1 
ATOM   1668 N ND2  . ASN A 1 248 ? 115.454 108.590 143.756 1.00 43.05  ? 248 ASN U ND2  1 
ATOM   1669 N N    . ALA A 1 249 ? 120.925 106.146 144.739 1.00 39.41  ? 249 ALA U N    1 
ATOM   1670 C CA   . ALA A 1 249 ? 121.607 104.971 145.277 1.00 41.37  ? 249 ALA U CA   1 
ATOM   1671 C C    . ALA A 1 249 ? 120.946 103.701 144.750 1.00 48.26  ? 249 ALA U C    1 
ATOM   1672 O O    . ALA A 1 249 ? 121.009 103.424 143.547 1.00 54.72  ? 249 ALA U O    1 
ATOM   1673 C CB   . ALA A 1 249 ? 121.621 104.988 146.809 1.00 38.97  ? 249 ALA U CB   1 
ATOM   1674 N N    . HIS A 1 250 ? 120.327 102.917 145.630 1.00 47.45  ? 250 HIS U N    1 
ATOM   1675 C CA   . HIS A 1 250 ? 119.575 101.753 145.176 1.00 46.90  ? 250 HIS U CA   1 
ATOM   1676 C C    . HIS A 1 250 ? 118.370 102.212 144.364 1.00 44.47  ? 250 HIS U C    1 
ATOM   1677 O O    . HIS A 1 250 ? 117.614 103.087 144.792 1.00 41.58  ? 250 HIS U O    1 
ATOM   1678 C CB   . HIS A 1 250 ? 119.133 100.907 146.370 1.00 47.00  ? 250 HIS U CB   1 
ATOM   1679 C CG   . HIS A 1 250 ? 118.378 99.671  145.987 1.00 50.87  ? 250 HIS U CG   1 
ATOM   1680 N ND1  . HIS A 1 250 ? 117.034 99.511  146.238 1.00 53.16  ? 250 HIS U ND1  1 
ATOM   1681 C CD2  . HIS A 1 250 ? 118.780 98.537  145.365 1.00 48.08  ? 250 HIS U CD2  1 
ATOM   1682 C CE1  . HIS A 1 250 ? 116.641 98.331  145.792 1.00 53.21  ? 250 HIS U CE1  1 
ATOM   1683 N NE2  . HIS A 1 250 ? 117.682 97.721  145.256 1.00 51.82  ? 250 HIS U NE2  1 
ATOM   1684 N N    . TYR A 1 251 ? 118.190 101.613 143.187 1.00 43.60  ? 251 TYR U N    1 
ATOM   1685 C CA   . TYR A 1 251 ? 117.114 101.982 142.268 1.00 43.61  ? 251 TYR U CA   1 
ATOM   1686 C C    . TYR A 1 251 ? 116.430 100.724 141.727 1.00 45.07  ? 251 TYR U C    1 
ATOM   1687 O O    . TYR A 1 251 ? 116.295 100.545 140.518 1.00 50.50  ? 251 TYR U O    1 
ATOM   1688 C CB   . TYR A 1 251 ? 117.668 102.839 141.128 1.00 47.43  ? 251 TYR U CB   1 
ATOM   1689 C CG   . TYR A 1 251 ? 117.054 104.214 141.023 1.00 44.10  ? 251 TYR U CG   1 
ATOM   1690 C CD1  . TYR A 1 251 ? 115.714 104.425 141.312 1.00 36.50  ? 251 TYR U CD1  1 
ATOM   1691 C CD2  . TYR A 1 251 ? 117.823 105.306 140.647 1.00 43.24  ? 251 TYR U CD2  1 
ATOM   1692 C CE1  . TYR A 1 251 ? 115.153 105.685 141.214 1.00 41.45  ? 251 TYR U CE1  1 
ATOM   1693 C CE2  . TYR A 1 251 ? 117.274 106.567 140.552 1.00 37.66  ? 251 TYR U CE2  1 
ATOM   1694 C CZ   . TYR A 1 251 ? 115.940 106.750 140.836 1.00 41.72  ? 251 TYR U CZ   1 
ATOM   1695 O OH   . TYR A 1 251 ? 115.394 108.010 140.744 1.00 42.61  ? 251 TYR U OH   1 
ATOM   1696 N N    . GLU A 1 252 ? 115.973 99.864  142.641 1.00 48.81  ? 252 GLU U N    1 
ATOM   1697 C CA   . GLU A 1 252 ? 115.277 98.627  142.294 1.00 50.74  ? 252 GLU U CA   1 
ATOM   1698 C C    . GLU A 1 252 ? 116.129 97.854  141.285 1.00 57.80  ? 252 GLU U C    1 
ATOM   1699 O O    . GLU A 1 252 ? 117.231 97.415  141.626 1.00 60.37  ? 252 GLU U O    1 
ATOM   1700 C CB   . GLU A 1 252 ? 113.869 98.940  141.762 1.00 47.84  ? 252 GLU U CB   1 
ATOM   1701 C CG   . GLU A 1 252 ? 112.977 97.738  141.437 1.00 52.63  ? 252 GLU U CG   1 
ATOM   1702 C CD   . GLU A 1 252 ? 112.611 96.918  142.659 1.00 58.56  ? 252 GLU U CD   1 
ATOM   1703 O OE1  . GLU A 1 252 ? 112.832 97.392  143.794 1.00 58.69  ? 252 GLU U OE1  1 
ATOM   1704 O OE2  . GLU A 1 252 ? 112.094 95.795  142.485 1.00 56.89  ? 252 GLU U OE2  1 
ATOM   1705 N N    . SER A 1 253 ? 115.639 97.681  140.054 1.00 52.14  ? 253 SER U N    1 
ATOM   1706 C CA   . SER A 1 253 ? 116.353 96.866  139.075 1.00 48.18  ? 253 SER U CA   1 
ATOM   1707 C C    . SER A 1 253 ? 117.692 97.496  138.716 1.00 51.74  ? 253 SER U C    1 
ATOM   1708 O O    . SER A 1 253 ? 118.733 96.828  138.739 1.00 56.47  ? 253 SER U O    1 
ATOM   1709 C CB   . SER A 1 253 ? 115.493 96.671  137.827 1.00 45.75  ? 253 SER U CB   1 
ATOM   1710 O OG   . SER A 1 253 ? 114.331 95.916  138.119 1.00 54.13  ? 253 SER U OG   1 
ATOM   1711 N N    . GLN A 1 254 ? 117.676 98.779  138.351 1.00 45.15  ? 254 GLN U N    1 
ATOM   1712 C CA   . GLN A 1 254 ? 118.868 99.614  138.209 1.00 43.00  ? 254 GLN U CA   1 
ATOM   1713 C C    . GLN A 1 254 ? 119.756 99.214  137.035 1.00 45.94  ? 254 GLN U C    1 
ATOM   1714 O O    . GLN A 1 254 ? 120.726 99.915  136.727 1.00 49.53  ? 254 GLN U O    1 
ATOM   1715 C CB   . GLN A 1 254 ? 119.681 99.598  139.510 1.00 36.85  ? 254 GLN U CB   1 
ATOM   1716 C CG   . GLN A 1 254 ? 120.446 100.880 139.785 1.00 41.91  ? 254 GLN U CG   1 
ATOM   1717 C CD   . GLN A 1 254 ? 121.369 100.763 140.981 1.00 45.37  ? 254 GLN U CD   1 
ATOM   1718 O OE1  . GLN A 1 254 ? 121.717 99.661  141.404 1.00 51.51  ? 254 GLN U OE1  1 
ATOM   1719 N NE2  . GLN A 1 254 ? 121.757 101.898 141.541 1.00 45.60  ? 254 GLN U NE2  1 
ATOM   1720 N N    . GLY A 1 255 ? 119.448 98.103  136.370 1.00 44.80  ? 255 GLY U N    1 
ATOM   1721 C CA   . GLY A 1 255 ? 120.195 97.751  135.179 1.00 39.18  ? 255 GLY U CA   1 
ATOM   1722 C C    . GLY A 1 255 ? 119.472 98.161  133.912 1.00 42.73  ? 255 GLY U C    1 
ATOM   1723 O O    . GLY A 1 255 ? 120.063 98.758  133.010 1.00 49.32  ? 255 GLY U O    1 
ATOM   1724 N N    . LEU A 1 256 ? 118.179 97.842  133.847 1.00 36.44  ? 256 LEU U N    1 
ATOM   1725 C CA   . LEU A 1 256 ? 117.343 98.257  132.723 1.00 33.26  ? 256 LEU U CA   1 
ATOM   1726 C C    . LEU A 1 256 ? 116.973 99.734  132.800 1.00 31.94  ? 256 LEU U C    1 
ATOM   1727 O O    . LEU A 1 256 ? 116.785 100.378 131.761 1.00 40.10  ? 256 LEU U O    1 
ATOM   1728 C CB   . LEU A 1 256 ? 116.070 97.407  132.662 1.00 32.90  ? 256 LEU U CB   1 
ATOM   1729 C CG   . LEU A 1 256 ? 116.124 95.964  132.139 1.00 34.26  ? 256 LEU U CG   1 
ATOM   1730 C CD1  . LEU A 1 256 ? 117.030 95.061  132.967 1.00 35.97  ? 256 LEU U CD1  1 
ATOM   1731 C CD2  . LEU A 1 256 ? 114.722 95.383  132.066 1.00 35.49  ? 256 LEU U CD2  1 
ATOM   1732 N N    . TYR A 1 257 ? 116.865 100.276 134.017 1.00 27.46  ? 257 TYR U N    1 
ATOM   1733 C CA   . TYR A 1 257 ? 116.436 101.660 134.201 1.00 27.66  ? 257 TYR U CA   1 
ATOM   1734 C C    . TYR A 1 257 ? 117.452 102.649 133.635 1.00 33.61  ? 257 TYR U C    1 
ATOM   1735 O O    . TYR A 1 257 ? 117.073 103.626 132.973 1.00 34.32  ? 257 TYR U O    1 
ATOM   1736 C CB   . TYR A 1 257 ? 116.191 101.910 135.691 1.00 29.20  ? 257 TYR U CB   1 
ATOM   1737 C CG   . TYR A 1 257 ? 115.660 103.281 136.040 1.00 34.25  ? 257 TYR U CG   1 
ATOM   1738 C CD1  . TYR A 1 257 ? 114.350 103.631 135.746 1.00 39.15  ? 257 TYR U CD1  1 
ATOM   1739 C CD2  . TYR A 1 257 ? 116.456 104.211 136.694 1.00 31.81  ? 257 TYR U CD2  1 
ATOM   1740 C CE1  . TYR A 1 257 ? 113.856 104.881 136.070 1.00 36.03  ? 257 TYR U CE1  1 
ATOM   1741 C CE2  . TYR A 1 257 ? 115.969 105.458 137.022 1.00 29.73  ? 257 TYR U CE2  1 
ATOM   1742 C CZ   . TYR A 1 257 ? 114.671 105.788 136.710 1.00 34.38  ? 257 TYR U CZ   1 
ATOM   1743 O OH   . TYR A 1 257 ? 114.184 107.031 137.039 1.00 36.82  ? 257 TYR U OH   1 
ATOM   1744 N N    . ARG A 1 258 ? 118.743 102.394 133.850 1.00 32.49  ? 258 ARG U N    1 
ATOM   1745 C CA   . ARG A 1 258 ? 119.775 103.277 133.311 1.00 26.54  ? 258 ARG U CA   1 
ATOM   1746 C C    . ARG A 1 258 ? 119.796 103.231 131.786 1.00 33.72  ? 258 ARG U C    1 
ATOM   1747 O O    . ARG A 1 258 ? 119.940 104.269 131.126 1.00 40.30  ? 258 ARG U O    1 
ATOM   1748 C CB   . ARG A 1 258 ? 121.140 102.895 133.882 1.00 29.14  ? 258 ARG U CB   1 
ATOM   1749 C CG   . ARG A 1 258 ? 121.186 102.870 135.404 1.00 33.79  ? 258 ARG U CG   1 
ATOM   1750 C CD   . ARG A 1 258 ? 122.608 102.737 135.927 1.00 33.93  ? 258 ARG U CD   1 
ATOM   1751 N NE   . ARG A 1 258 ? 122.718 103.114 137.329 1.00 35.85  ? 258 ARG U NE   1 
ATOM   1752 C CZ   . ARG A 1 258 ? 123.696 102.727 138.139 1.00 35.58  ? 258 ARG U CZ   1 
ATOM   1753 N NH1  . ARG A 1 258 ? 124.667 101.934 137.715 1.00 39.81  ? 258 ARG U NH1  1 
ATOM   1754 N NH2  . ARG A 1 258 ? 123.697 103.138 139.402 1.00 31.57  ? 258 ARG U NH2  1 
ATOM   1755 N N    . PHE A 1 259 ? 119.642 102.036 131.217 1.00 33.64  ? 259 PHE U N    1 
ATOM   1756 C CA   . PHE A 1 259 ? 119.603 101.886 129.766 1.00 31.59  ? 259 PHE U CA   1 
ATOM   1757 C C    . PHE A 1 259 ? 118.408 102.625 129.170 1.00 32.83  ? 259 PHE U C    1 
ATOM   1758 O O    . PHE A 1 259 ? 118.539 103.317 128.147 1.00 35.80  ? 259 PHE U O    1 
ATOM   1759 C CB   . PHE A 1 259 ? 119.565 100.393 129.422 1.00 27.52  ? 259 PHE U CB   1 
ATOM   1760 C CG   . PHE A 1 259 ? 119.299 100.097 127.979 1.00 35.62  ? 259 PHE U CG   1 
ATOM   1761 C CD1  . PHE A 1 259 ? 120.260 100.347 127.018 1.00 34.47  ? 259 PHE U CD1  1 
ATOM   1762 C CD2  . PHE A 1 259 ? 118.091 99.546  127.585 1.00 33.15  ? 259 PHE U CD2  1 
ATOM   1763 C CE1  . PHE A 1 259 ? 120.019 100.068 125.689 1.00 33.29  ? 259 PHE U CE1  1 
ATOM   1764 C CE2  . PHE A 1 259 ? 117.843 99.267  126.258 1.00 33.12  ? 259 PHE U CE2  1 
ATOM   1765 C CZ   . PHE A 1 259 ? 118.808 99.530  125.309 1.00 31.31  ? 259 PHE U CZ   1 
ATOM   1766 N N    . ALA A 1 260 ? 117.240 102.509 129.808 1.00 30.49  ? 260 ALA U N    1 
ATOM   1767 C CA   . ALA A 1 260 ? 116.059 103.222 129.331 1.00 28.52  ? 260 ALA U CA   1 
ATOM   1768 C C    . ALA A 1 260 ? 116.238 104.734 129.427 1.00 31.39  ? 260 ALA U C    1 
ATOM   1769 O O    . ALA A 1 260 ? 115.842 105.472 128.515 1.00 40.65  ? 260 ALA U O    1 
ATOM   1770 C CB   . ALA A 1 260 ? 114.827 102.777 130.118 1.00 30.55  ? 260 ALA U CB   1 
ATOM   1771 N N    . ASN A 1 261 ? 116.839 105.214 130.520 1.00 33.60  ? 261 ASN U N    1 
ATOM   1772 C CA   . ASN A 1 261 ? 117.107 106.644 130.660 1.00 36.03  ? 261 ASN U CA   1 
ATOM   1773 C C    . ASN A 1 261 ? 118.026 107.143 129.550 1.00 32.30  ? 261 ASN U C    1 
ATOM   1774 O O    . ASN A 1 261 ? 117.772 108.189 128.935 1.00 36.65  ? 261 ASN U O    1 
ATOM   1775 C CB   . ASN A 1 261 ? 117.720 106.918 132.037 1.00 34.87  ? 261 ASN U CB   1 
ATOM   1776 C CG   . ASN A 1 261 ? 117.746 108.391 132.384 1.00 37.97  ? 261 ASN U CG   1 
ATOM   1777 O OD1  . ASN A 1 261 ? 116.943 109.174 131.884 1.00 46.53  ? 261 ASN U OD1  1 
ATOM   1778 N ND2  . ASN A 1 261 ? 118.675 108.777 133.249 1.00 30.91  ? 261 ASN U ND2  1 
ATOM   1779 N N    . PHE A 1 262 ? 119.092 106.388 129.276 1.00 25.45  ? 262 PHE U N    1 
ATOM   1780 C CA   . PHE A 1 262 ? 120.022 106.749 128.210 1.00 34.45  ? 262 PHE U CA   1 
ATOM   1781 C C    . PHE A 1 262 ? 119.307 106.843 126.867 1.00 37.84  ? 262 PHE U C    1 
ATOM   1782 O O    . PHE A 1 262 ? 119.457 107.834 126.132 1.00 36.19  ? 262 PHE U O    1 
ATOM   1783 C CB   . PHE A 1 262 ? 121.147 105.711 128.160 1.00 30.88  ? 262 PHE U CB   1 
ATOM   1784 C CG   . PHE A 1 262 ? 122.138 105.926 127.055 1.00 35.40  ? 262 PHE U CG   1 
ATOM   1785 C CD1  . PHE A 1 262 ? 123.102 106.912 127.150 1.00 35.00  ? 262 PHE U CD1  1 
ATOM   1786 C CD2  . PHE A 1 262 ? 122.101 105.136 125.917 1.00 34.55  ? 262 PHE U CD2  1 
ATOM   1787 C CE1  . PHE A 1 262 ? 124.014 107.106 126.136 1.00 35.87  ? 262 PHE U CE1  1 
ATOM   1788 C CE2  . PHE A 1 262 ? 123.008 105.328 124.898 1.00 30.14  ? 262 PHE U CE2  1 
ATOM   1789 C CZ   . PHE A 1 262 ? 123.966 106.315 125.006 1.00 31.04  ? 262 PHE U CZ   1 
ATOM   1790 N N    . VAL A 1 263 ? 118.496 105.831 126.546 1.00 36.18  ? 263 VAL U N    1 
ATOM   1791 C CA   . VAL A 1 263 ? 117.808 105.799 125.255 1.00 28.90  ? 263 VAL U CA   1 
ATOM   1792 C C    . VAL A 1 263 ? 116.844 106.976 125.132 1.00 30.61  ? 263 VAL U C    1 
ATOM   1793 O O    . VAL A 1 263 ? 116.801 107.668 124.102 1.00 42.00  ? 263 VAL U O    1 
ATOM   1794 C CB   . VAL A 1 263 ? 117.084 104.454 125.073 1.00 30.61  ? 263 VAL U CB   1 
ATOM   1795 C CG1  . VAL A 1 263 ? 116.104 104.519 123.914 1.00 35.44  ? 263 VAL U CG1  1 
ATOM   1796 C CG2  . VAL A 1 263 ? 118.094 103.334 124.864 1.00 33.56  ? 263 VAL U CG2  1 
ATOM   1797 N N    . PHE A 1 264 ? 116.054 107.220 126.183 1.00 27.62  ? 264 PHE U N    1 
ATOM   1798 C CA   . PHE A 1 264 ? 115.066 108.290 126.136 1.00 25.82  ? 264 PHE U CA   1 
ATOM   1799 C C    . PHE A 1 264 ? 115.725 109.651 125.954 1.00 24.42  ? 264 PHE U C    1 
ATOM   1800 O O    . PHE A 1 264 ? 115.278 110.459 125.129 1.00 32.74  ? 264 PHE U O    1 
ATOM   1801 C CB   . PHE A 1 264 ? 114.219 108.287 127.409 1.00 26.97  ? 264 PHE U CB   1 
ATOM   1802 C CG   . PHE A 1 264 ? 113.075 107.313 127.381 1.00 32.70  ? 264 PHE U CG   1 
ATOM   1803 C CD1  . PHE A 1 264 ? 112.155 107.331 126.346 1.00 33.71  ? 264 PHE U CD1  1 
ATOM   1804 C CD2  . PHE A 1 264 ? 112.903 106.396 128.405 1.00 28.78  ? 264 PHE U CD2  1 
ATOM   1805 C CE1  . PHE A 1 264 ? 111.098 106.442 126.324 1.00 32.63  ? 264 PHE U CE1  1 
ATOM   1806 C CE2  . PHE A 1 264 ? 111.849 105.505 128.389 1.00 29.61  ? 264 PHE U CE2  1 
ATOM   1807 C CZ   . PHE A 1 264 ? 110.945 105.529 127.347 1.00 34.95  ? 264 PHE U CZ   1 
ATOM   1808 N N    . ILE A 1 265 ? 116.802 109.918 126.698 1.00 27.58  ? 265 ILE U N    1 
ATOM   1809 C CA   . ILE A 1 265 ? 117.468 111.212 126.572 1.00 28.73  ? 265 ILE U CA   1 
ATOM   1810 C C    . ILE A 1 265 ? 118.071 111.381 125.184 1.00 31.11  ? 265 ILE U C    1 
ATOM   1811 O O    . ILE A 1 265 ? 117.970 112.458 124.576 1.00 35.91  ? 265 ILE U O    1 
ATOM   1812 C CB   . ILE A 1 265 ? 118.525 111.385 127.679 1.00 30.59  ? 265 ILE U CB   1 
ATOM   1813 C CG1  . ILE A 1 265 ? 117.851 111.409 129.055 1.00 26.43  ? 265 ILE U CG1  1 
ATOM   1814 C CG2  . ILE A 1 265 ? 119.329 112.656 127.464 1.00 28.36  ? 265 ILE U CG2  1 
ATOM   1815 C CD1  . ILE A 1 265 ? 118.792 111.731 130.192 1.00 25.55  ? 265 ILE U CD1  1 
ATOM   1816 N N    . LEU A 1 266 ? 118.680 110.321 124.643 1.00 31.53  ? 266 LEU U N    1 
ATOM   1817 C CA   . LEU A 1 266 ? 119.263 110.414 123.303 1.00 27.00  ? 266 LEU U CA   1 
ATOM   1818 C C    . LEU A 1 266 ? 118.207 110.769 122.258 1.00 31.96  ? 266 LEU U C    1 
ATOM   1819 O O    . LEU A 1 266 ? 118.380 111.719 121.472 1.00 33.24  ? 266 LEU U O    1 
ATOM   1820 C CB   . LEU A 1 266 ? 119.956 109.094 122.957 1.00 28.68  ? 266 LEU U CB   1 
ATOM   1821 C CG   . LEU A 1 266 ? 120.573 108.939 121.564 1.00 33.01  ? 266 LEU U CG   1 
ATOM   1822 C CD1  . LEU A 1 266 ? 121.784 109.839 121.404 1.00 36.93  ? 266 LEU U CD1  1 
ATOM   1823 C CD2  . LEU A 1 266 ? 120.949 107.490 121.315 1.00 26.98  ? 266 LEU U CD2  1 
ATOM   1824 N N    . MET A 1 267 ? 117.092 110.029 122.249 1.00 30.13  ? 267 MET U N    1 
ATOM   1825 C CA   . MET A 1 267 ? 116.048 110.290 121.256 1.00 29.28  ? 267 MET U CA   1 
ATOM   1826 C C    . MET A 1 267 ? 115.444 111.681 121.422 1.00 34.34  ? 267 MET U C    1 
ATOM   1827 O O    . MET A 1 267 ? 115.208 112.387 120.427 1.00 44.49  ? 267 MET U O    1 
ATOM   1828 C CB   . MET A 1 267 ? 114.962 109.216 121.330 1.00 30.05  ? 267 MET U CB   1 
ATOM   1829 C CG   . MET A 1 267 ? 115.496 107.794 121.326 1.00 34.11  ? 267 MET U CG   1 
ATOM   1830 S SD   . MET A 1 267 ? 114.206 106.530 121.320 1.00 59.83  ? 267 MET U SD   1 
ATOM   1831 C CE   . MET A 1 267 ? 112.890 107.375 122.184 1.00 40.03  ? 267 MET U CE   1 
ATOM   1832 N N    . GLY A 1 268 ? 115.186 112.098 122.666 1.00 27.15  ? 268 GLY U N    1 
ATOM   1833 C CA   . GLY A 1 268 ? 114.613 113.415 122.880 1.00 23.27  ? 268 GLY U CA   1 
ATOM   1834 C C    . GLY A 1 268 ? 115.518 114.539 122.410 1.00 22.51  ? 268 GLY U C    1 
ATOM   1835 O O    . GLY A 1 268 ? 115.057 115.497 121.775 1.00 27.32  ? 268 GLY U O    1 
ATOM   1836 N N    . VAL A 1 269 ? 116.819 114.429 122.690 1.00 25.89  ? 269 VAL U N    1 
ATOM   1837 C CA   . VAL A 1 269 ? 117.753 115.465 122.261 1.00 27.69  ? 269 VAL U CA   1 
ATOM   1838 C C    . VAL A 1 269 ? 117.805 115.539 120.739 1.00 33.47  ? 269 VAL U C    1 
ATOM   1839 O O    . VAL A 1 269 ? 117.781 116.634 120.159 1.00 43.49  ? 269 VAL U O    1 
ATOM   1840 C CB   . VAL A 1 269 ? 119.146 115.218 122.868 1.00 32.53  ? 269 VAL U CB   1 
ATOM   1841 C CG1  . VAL A 1 269 ? 120.172 116.139 122.235 1.00 31.42  ? 269 VAL U CG1  1 
ATOM   1842 C CG2  . VAL A 1 269 ? 119.114 115.439 124.370 1.00 33.56  ? 269 VAL U CG2  1 
ATOM   1843 N N    . CYS A 1 270 ? 117.848 114.383 120.071 1.00 37.75  ? 270 CYS U N    1 
ATOM   1844 C CA   . CYS A 1 270 ? 117.850 114.388 118.607 1.00 33.16  ? 270 CYS U CA   1 
ATOM   1845 C C    . CYS A 1 270 ? 116.612 115.086 118.046 1.00 33.05  ? 270 CYS U C    1 
ATOM   1846 O O    . CYS A 1 270 ? 116.713 115.972 117.175 1.00 42.27  ? 270 CYS U O    1 
ATOM   1847 C CB   . CYS A 1 270 ? 117.944 112.953 118.084 1.00 30.30  ? 270 CYS U CB   1 
ATOM   1848 S SG   . CYS A 1 270 ? 119.515 112.129 118.427 1.00 52.44  ? 270 CYS U SG   1 
ATOM   1849 N N    . CYS A 1 271 ? 115.430 114.710 118.545 1.00 26.24  ? 271 CYS U N    1 
ATOM   1850 C CA   . CYS A 1 271 ? 114.189 115.264 118.008 1.00 27.48  ? 271 CYS U CA   1 
ATOM   1851 C C    . CYS A 1 271 ? 114.103 116.770 118.235 1.00 33.18  ? 271 CYS U C    1 
ATOM   1852 O O    . CYS A 1 271 ? 113.708 117.523 117.330 1.00 39.58  ? 271 CYS U O    1 
ATOM   1853 C CB   . CYS A 1 271 ? 112.987 114.552 118.628 1.00 30.99  ? 271 CYS U CB   1 
ATOM   1854 S SG   . CYS A 1 271 ? 112.821 112.824 118.129 1.00 57.96  ? 271 CYS U SG   1 
ATOM   1855 N N    . ILE A 1 272 ? 114.489 117.236 119.424 1.00 30.03  ? 272 ILE U N    1 
ATOM   1856 C CA   . ILE A 1 272 ? 114.370 118.662 119.722 1.00 30.38  ? 272 ILE U CA   1 
ATOM   1857 C C    . ILE A 1 272 ? 115.378 119.467 118.907 1.00 33.66  ? 272 ILE U C    1 
ATOM   1858 O O    . ILE A 1 272 ? 115.078 120.580 118.451 1.00 36.62  ? 272 ILE U O    1 
ATOM   1859 C CB   . ILE A 1 272 ? 114.522 118.907 121.231 1.00 32.79  ? 272 ILE U CB   1 
ATOM   1860 C CG1  . ILE A 1 272 ? 113.333 118.296 121.975 1.00 29.52  ? 272 ILE U CG1  1 
ATOM   1861 C CG2  . ILE A 1 272 ? 114.630 120.395 121.532 1.00 26.74  ? 272 ILE U CG2  1 
ATOM   1862 C CD1  . ILE A 1 272 ? 112.009 118.940 121.640 1.00 27.59  ? 272 ILE U CD1  1 
ATOM   1863 N N    . TYR A 1 273 ? 116.576 118.920 118.692 1.00 33.64  ? 273 TYR U N    1 
ATOM   1864 C CA   . TYR A 1 273 ? 117.560 119.587 117.839 1.00 31.65  ? 273 TYR U CA   1 
ATOM   1865 C C    . TYR A 1 273 ? 117.013 119.778 116.427 1.00 36.63  ? 273 TYR U C    1 
ATOM   1866 O O    . TYR A 1 273 ? 117.099 120.879 115.850 1.00 39.18  ? 273 TYR U O    1 
ATOM   1867 C CB   . TYR A 1 273 ? 118.850 118.763 117.829 1.00 30.67  ? 273 TYR U CB   1 
ATOM   1868 C CG   . TYR A 1 273 ? 120.020 119.374 117.091 1.00 41.88  ? 273 TYR U CG   1 
ATOM   1869 C CD1  . TYR A 1 273 ? 120.706 120.465 117.611 1.00 41.43  ? 273 TYR U CD1  1 
ATOM   1870 C CD2  . TYR A 1 273 ? 120.423 118.872 115.860 1.00 39.31  ? 273 TYR U CD2  1 
ATOM   1871 C CE1  . TYR A 1 273 ? 121.767 121.027 116.933 1.00 37.34  ? 273 TYR U CE1  1 
ATOM   1872 C CE2  . TYR A 1 273 ? 121.480 119.431 115.173 1.00 40.08  ? 273 TYR U CE2  1 
ATOM   1873 C CZ   . TYR A 1 273 ? 122.150 120.507 115.714 1.00 45.77  ? 273 TYR U CZ   1 
ATOM   1874 O OH   . TYR A 1 273 ? 123.207 121.066 115.035 1.00 49.98  ? 273 TYR U OH   1 
ATOM   1875 N N    . SER A 1 274 ? 116.427 118.722 115.857 1.00 33.18  ? 274 SER U N    1 
ATOM   1876 C CA   . SER A 1 274 ? 115.857 118.839 114.514 1.00 31.95  ? 274 SER U CA   1 
ATOM   1877 C C    . SER A 1 274 ? 114.722 119.862 114.470 1.00 33.97  ? 274 SER U C    1 
ATOM   1878 O O    . SER A 1 274 ? 114.628 120.666 113.525 1.00 42.97  ? 274 SER U O    1 
ATOM   1879 C CB   . SER A 1 274 ? 115.365 117.473 114.043 1.00 36.30  ? 274 SER U CB   1 
ATOM   1880 O OG   . SER A 1 274 ? 116.366 116.486 114.217 1.00 37.90  ? 274 SER U OG   1 
ATOM   1881 N N    . LEU A 1 275 ? 113.860 119.858 115.490 1.00 30.34  ? 275 LEU U N    1 
ATOM   1882 C CA   . LEU A 1 275 ? 112.750 120.803 115.525 1.00 33.18  ? 275 LEU U CA   1 
ATOM   1883 C C    . LEU A 1 275 ? 113.251 122.243 115.575 1.00 35.96  ? 275 LEU U C    1 
ATOM   1884 O O    . LEU A 1 275 ? 112.715 123.124 114.887 1.00 36.83  ? 275 LEU U O    1 
ATOM   1885 C CB   . LEU A 1 275 ? 111.843 120.507 116.720 1.00 29.46  ? 275 LEU U CB   1 
ATOM   1886 C CG   . LEU A 1 275 ? 110.581 121.360 116.831 1.00 32.53  ? 275 LEU U CG   1 
ATOM   1887 C CD1  . LEU A 1 275 ? 109.725 121.203 115.583 1.00 31.46  ? 275 LEU U CD1  1 
ATOM   1888 C CD2  . LEU A 1 275 ? 109.788 120.999 118.072 1.00 33.34  ? 275 LEU U CD2  1 
ATOM   1889 N N    . PHE A 1 276 ? 114.283 122.499 116.385 1.00 33.72  ? 276 PHE U N    1 
ATOM   1890 C CA   . PHE A 1 276 ? 114.840 123.844 116.479 1.00 23.36  ? 276 PHE U CA   1 
ATOM   1891 C C    . PHE A 1 276 ? 115.419 124.301 115.148 1.00 25.68  ? 276 PHE U C    1 
ATOM   1892 O O    . PHE A 1 276 ? 115.243 125.463 114.751 1.00 31.01  ? 276 PHE U O    1 
ATOM   1893 C CB   . PHE A 1 276 ? 115.900 123.906 117.579 1.00 23.56  ? 276 PHE U CB   1 
ATOM   1894 C CG   . PHE A 1 276 ? 115.334 124.032 118.964 1.00 31.77  ? 276 PHE U CG   1 
ATOM   1895 C CD1  . PHE A 1 276 ? 113.966 124.094 119.167 1.00 31.35  ? 276 PHE U CD1  1 
ATOM   1896 C CD2  . PHE A 1 276 ? 116.171 124.107 120.061 1.00 27.95  ? 276 PHE U CD2  1 
ATOM   1897 C CE1  . PHE A 1 276 ? 113.443 124.214 120.440 1.00 24.95  ? 276 PHE U CE1  1 
ATOM   1898 C CE2  . PHE A 1 276 ? 115.659 124.230 121.337 1.00 26.04  ? 276 PHE U CE2  1 
ATOM   1899 C CZ   . PHE A 1 276 ? 114.293 124.284 121.526 1.00 22.27  ? 276 PHE U CZ   1 
ATOM   1900 N N    . ASN A 1 277 ? 116.111 123.406 114.432 1.00 31.70  ? 277 ASN U N    1 
ATOM   1901 C CA   . ASN A 1 277 ? 116.651 123.798 113.130 1.00 26.26  ? 277 ASN U CA   1 
ATOM   1902 C C    . ASN A 1 277 ? 115.538 124.168 112.148 1.00 31.12  ? 277 ASN U C    1 
ATOM   1903 O O    . ASN A 1 277 ? 115.631 125.182 111.427 1.00 41.23  ? 277 ASN U O    1 
ATOM   1904 C CB   . ASN A 1 277 ? 117.514 122.674 112.558 1.00 27.73  ? 277 ASN U CB   1 
ATOM   1905 C CG   . ASN A 1 277 ? 118.874 122.580 113.229 1.00 36.76  ? 277 ASN U CG   1 
ATOM   1906 O OD1  . ASN A 1 277 ? 119.092 123.148 114.298 1.00 30.73  ? 277 ASN U OD1  1 
ATOM   1907 N ND2  . ASN A 1 277 ? 119.795 121.868 112.594 1.00 39.65  ? 277 ASN U ND2  1 
ATOM   1908 N N    . VAL A 1 278 ? 114.463 123.374 112.116 1.00 31.00  ? 278 VAL U N    1 
ATOM   1909 C CA   . VAL A 1 278 ? 113.358 123.679 111.202 1.00 29.92  ? 278 VAL U CA   1 
ATOM   1910 C C    . VAL A 1 278 ? 112.706 125.014 111.561 1.00 34.50  ? 278 VAL U C    1 
ATOM   1911 O O    . VAL A 1 278 ? 112.385 125.832 110.678 1.00 39.75  ? 278 VAL U O    1 
ATOM   1912 C CB   . VAL A 1 278 ? 112.340 122.523 111.207 1.00 35.59  ? 278 VAL U CB   1 
ATOM   1913 C CG1  . VAL A 1 278 ? 111.097 122.903 110.428 1.00 37.34  ? 278 VAL U CG1  1 
ATOM   1914 C CG2  . VAL A 1 278 ? 112.968 121.270 110.623 1.00 32.90  ? 278 VAL U CG2  1 
ATOM   1915 N N    . ILE A 1 279 ? 112.506 125.267 112.858 1.00 33.11  ? 279 ILE U N    1 
ATOM   1916 C CA   . ILE A 1 279 ? 111.890 126.525 113.272 1.00 30.18  ? 279 ILE U CA   1 
ATOM   1917 C C    . ILE A 1 279 ? 112.784 127.708 112.916 1.00 33.54  ? 279 ILE U C    1 
ATOM   1918 O O    . ILE A 1 279 ? 112.297 128.783 112.543 1.00 39.82  ? 279 ILE U O    1 
ATOM   1919 C CB   . ILE A 1 279 ? 111.561 126.492 114.776 1.00 30.85  ? 279 ILE U CB   1 
ATOM   1920 C CG1  . ILE A 1 279 ? 110.416 125.520 115.050 1.00 29.39  ? 279 ILE U CG1  1 
ATOM   1921 C CG2  . ILE A 1 279 ? 111.167 127.873 115.274 1.00 31.91  ? 279 ILE U CG2  1 
ATOM   1922 C CD1  . ILE A 1 279 ? 110.289 125.129 116.504 1.00 29.90  ? 279 ILE U CD1  1 
ATOM   1923 N N    . SER A 1 280 ? 114.106 127.530 113.002 1.00 31.90  ? 280 SER U N    1 
ATOM   1924 C CA   . SER A 1 280 ? 115.020 128.596 112.594 1.00 26.33  ? 280 SER U CA   1 
ATOM   1925 C C    . SER A 1 280 ? 114.882 128.912 111.108 1.00 28.85  ? 280 SER U C    1 
ATOM   1926 O O    . SER A 1 280 ? 114.911 130.083 110.706 1.00 35.94  ? 280 SER U O    1 
ATOM   1927 C CB   . SER A 1 280 ? 116.460 128.213 112.929 1.00 26.44  ? 280 SER U CB   1 
ATOM   1928 O OG   . SER A 1 280 ? 116.904 127.140 112.119 1.00 37.64  ? 280 SER U OG   1 
ATOM   1929 N N    . ILE A 1 281 ? 114.727 127.877 110.279 1.00 34.01  ? 281 ILE U N    1 
ATOM   1930 C CA   . ILE A 1 281 ? 114.514 128.113 108.848 1.00 36.49  ? 281 ILE U CA   1 
ATOM   1931 C C    . ILE A 1 281 ? 113.236 128.926 108.620 1.00 39.12  ? 281 ILE U C    1 
ATOM   1932 O O    . ILE A 1 281 ? 113.217 129.895 107.839 1.00 45.06  ? 281 ILE U O    1 
ATOM   1933 C CB   . ILE A 1 281 ? 114.476 126.776 108.086 1.00 34.52  ? 281 ILE U CB   1 
ATOM   1934 C CG1  . ILE A 1 281 ? 115.851 126.109 108.113 1.00 33.30  ? 281 ILE U CG1  1 
ATOM   1935 C CG2  . ILE A 1 281 ? 114.014 126.982 106.653 1.00 36.29  ? 281 ILE U CG2  1 
ATOM   1936 C CD1  . ILE A 1 281 ? 115.898 124.785 107.392 1.00 38.51  ? 281 ILE U CD1  1 
ATOM   1937 N N    . LEU A 1 282 ? 112.159 128.556 109.316 1.00 34.37  ? 282 LEU U N    1 
ATOM   1938 C CA   . LEU A 1 282 ? 110.902 129.289 109.162 1.00 34.27  ? 282 LEU U CA   1 
ATOM   1939 C C    . LEU A 1 282 ? 111.039 130.742 109.619 1.00 35.90  ? 282 LEU U C    1 
ATOM   1940 O O    . LEU A 1 282 ? 110.484 131.658 108.993 1.00 40.05  ? 282 LEU U O    1 
ATOM   1941 C CB   . LEU A 1 282 ? 109.790 128.583 109.933 1.00 37.89  ? 282 LEU U CB   1 
ATOM   1942 C CG   . LEU A 1 282 ? 109.213 127.327 109.274 1.00 38.13  ? 282 LEU U CG   1 
ATOM   1943 C CD1  . LEU A 1 282 ? 108.096 126.739 110.118 1.00 38.26  ? 282 LEU U CD1  1 
ATOM   1944 C CD2  . LEU A 1 282 ? 108.725 127.631 107.869 1.00 34.87  ? 282 LEU U CD2  1 
ATOM   1945 N N    . ILE A 1 283 ? 111.780 130.975 110.706 1.00 34.30  ? 283 ILE U N    1 
ATOM   1946 C CA   . ILE A 1 283 ? 111.981 132.335 111.199 1.00 31.79  ? 283 ILE U CA   1 
ATOM   1947 C C    . ILE A 1 283 ? 112.760 133.166 110.187 1.00 33.56  ? 283 ILE U C    1 
ATOM   1948 O O    . ILE A 1 283 ? 112.476 134.356 109.990 1.00 36.65  ? 283 ILE U O    1 
ATOM   1949 C CB   . ILE A 1 283 ? 112.679 132.308 112.572 1.00 30.50  ? 283 ILE U CB   1 
ATOM   1950 C CG1  . ILE A 1 283 ? 111.730 131.774 113.643 1.00 34.46  ? 283 ILE U CG1  1 
ATOM   1951 C CG2  . ILE A 1 283 ? 113.179 133.696 112.953 1.00 29.01  ? 283 ILE U CG2  1 
ATOM   1952 C CD1  . ILE A 1 283 ? 112.320 131.776 115.031 1.00 31.06  ? 283 ILE U CD1  1 
ATOM   1953 N N    . LYS A 1 284 ? 113.753 132.563 109.529 1.00 34.26  ? 284 LYS U N    1 
ATOM   1954 C CA   . LYS A 1 284 ? 114.481 133.292 108.494 1.00 32.78  ? 284 LYS U CA   1 
ATOM   1955 C C    . LYS A 1 284 ? 113.560 133.685 107.343 1.00 33.16  ? 284 LYS U C    1 
ATOM   1956 O O    . LYS A 1 284 ? 113.645 134.808 106.820 1.00 35.89  ? 284 LYS U O    1 
ATOM   1957 C CB   . LYS A 1 284 ? 115.653 132.457 107.976 1.00 31.24  ? 284 LYS U CB   1 
ATOM   1958 C CG   . LYS A 1 284 ? 116.538 133.201 106.988 1.00 30.46  ? 284 LYS U CG   1 
ATOM   1959 C CD   . LYS A 1 284 ? 117.265 132.243 106.061 1.00 35.64  ? 284 LYS U CD   1 
ATOM   1960 C CE   . LYS A 1 284 ? 118.317 132.968 105.234 1.00 37.02  ? 284 LYS U CE   1 
ATOM   1961 N NZ   . LYS A 1 284 ? 119.393 133.544 106.086 1.00 38.79  ? 284 LYS U NZ   1 
ATOM   1962 N N    . GLN A 1 285 ? 112.666 132.776 106.937 1.00 40.07  ? 285 GLN U N    1 
ATOM   1963 C CA   . GLN A 1 285 ? 111.702 133.130 105.893 1.00 38.02  ? 285 GLN U CA   1 
ATOM   1964 C C    . GLN A 1 285 ? 110.808 134.293 106.328 1.00 40.15  ? 285 GLN U C    1 
ATOM   1965 O O    . GLN A 1 285 ? 110.520 135.203 105.536 1.00 40.31  ? 285 GLN U O    1 
ATOM   1966 C CB   . GLN A 1 285 ? 110.857 131.917 105.507 1.00 39.53  ? 285 GLN U CB   1 
ATOM   1967 C CG   . GLN A 1 285 ? 111.646 130.810 104.835 1.00 45.74  ? 285 GLN U CG   1 
ATOM   1968 C CD   . GLN A 1 285 ? 110.758 129.834 104.088 1.00 53.13  ? 285 GLN U CD   1 
ATOM   1969 O OE1  . GLN A 1 285 ? 109.532 129.946 104.117 1.00 53.38  ? 285 GLN U OE1  1 
ATOM   1970 N NE2  . GLN A 1 285 ? 111.374 128.871 103.415 1.00 50.85  ? 285 GLN U NE2  1 
ATOM   1971 N N    . SER A 1 286 ? 110.360 134.280 107.587 1.00 42.63  ? 286 SER U N    1 
ATOM   1972 C CA   . SER A 1 286 ? 109.518 135.372 108.075 1.00 35.71  ? 286 SER U CA   1 
ATOM   1973 C C    . SER A 1 286 ? 110.279 136.695 108.083 1.00 40.11  ? 286 SER U C    1 
ATOM   1974 O O    . SER A 1 286 ? 109.711 137.751 107.772 1.00 45.87  ? 286 SER U O    1 
ATOM   1975 C CB   . SER A 1 286 ? 108.986 135.054 109.472 1.00 38.74  ? 286 SER U CB   1 
ATOM   1976 O OG   . SER A 1 286 ? 110.044 134.808 110.377 1.00 44.59  ? 286 SER U OG   1 
ATOM   1977 N N    . LEU A 1 287 ? 111.561 136.661 108.462 1.00 42.53  ? 287 LEU U N    1 
ATOM   1978 C CA   . LEU A 1 287 ? 112.381 137.868 108.420 1.00 34.65  ? 287 LEU U CA   1 
ATOM   1979 C C    . LEU A 1 287 ? 112.487 138.413 107.000 1.00 38.65  ? 287 LEU U C    1 
ATOM   1980 O O    . LEU A 1 287 ? 112.399 139.631 106.782 1.00 42.45  ? 287 LEU U O    1 
ATOM   1981 C CB   . LEU A 1 287 ? 113.773 137.588 108.984 1.00 38.47  ? 287 LEU U CB   1 
ATOM   1982 C CG   . LEU A 1 287 ? 113.903 137.512 110.503 1.00 39.03  ? 287 LEU U CG   1 
ATOM   1983 C CD1  . LEU A 1 287 ? 115.353 137.259 110.887 1.00 36.26  ? 287 LEU U CD1  1 
ATOM   1984 C CD2  . LEU A 1 287 ? 113.393 138.788 111.148 1.00 39.31  ? 287 LEU U CD2  1 
ATOM   1985 N N    . ASN A 1 288 ? 112.688 137.530 106.023 1.00 47.74  ? 288 ASN U N    1 
ATOM   1986 C CA   . ASN A 1 288 ? 112.707 137.979 104.632 1.00 42.28  ? 288 ASN U CA   1 
ATOM   1987 C C    . ASN A 1 288 ? 111.387 138.642 104.246 1.00 46.41  ? 288 ASN U C    1 
ATOM   1988 O O    . ASN A 1 288 ? 111.374 139.684 103.573 1.00 49.43  ? 288 ASN U O    1 
ATOM   1989 C CB   . ASN A 1 288 ? 113.019 136.808 103.702 1.00 43.58  ? 288 ASN U CB   1 
ATOM   1990 C CG   . ASN A 1 288 ? 114.505 136.590 103.516 1.00 48.58  ? 288 ASN U CG   1 
ATOM   1991 O OD1  . ASN A 1 288 ? 115.286 137.542 103.505 1.00 56.62  ? 288 ASN U OD1  1 
ATOM   1992 N ND2  . ASN A 1 288 ? 114.900 135.336 103.351 1.00 47.84  ? 288 ASN U ND2  1 
ATOM   1993 N N    . TRP A 1 289 ? 110.264 138.053 104.671 1.00 52.22  ? 289 TRP U N    1 
ATOM   1994 C CA   . TRP A 1 289 ? 108.960 138.625 104.339 1.00 50.77  ? 289 TRP U CA   1 
ATOM   1995 C C    . TRP A 1 289 ? 108.795 140.024 104.931 1.00 51.24  ? 289 TRP U C    1 
ATOM   1996 O O    . TRP A 1 289 ? 108.347 140.955 104.247 1.00 57.22  ? 289 TRP U O    1 
ATOM   1997 C CB   . TRP A 1 289 ? 107.837 137.711 104.823 1.00 54.38  ? 289 TRP U CB   1 
ATOM   1998 C CG   . TRP A 1 289 ? 106.471 138.262 104.540 1.00 56.97  ? 289 TRP U CG   1 
ATOM   1999 C CD1  . TRP A 1 289 ? 105.793 138.203 103.358 1.00 54.41  ? 289 TRP U CD1  1 
ATOM   2000 C CD2  . TRP A 1 289 ? 105.630 138.983 105.448 1.00 57.19  ? 289 TRP U CD2  1 
ATOM   2001 N NE1  . TRP A 1 289 ? 104.577 138.829 103.478 1.00 50.74  ? 289 TRP U NE1  1 
ATOM   2002 C CE2  . TRP A 1 289 ? 104.452 139.317 104.751 1.00 53.52  ? 289 TRP U CE2  1 
ATOM   2003 C CE3  . TRP A 1 289 ? 105.754 139.373 106.784 1.00 56.19  ? 289 TRP U CE3  1 
ATOM   2004 C CZ2  . TRP A 1 289 ? 103.408 140.023 105.343 1.00 53.77  ? 289 TRP U CZ2  1 
ATOM   2005 C CZ3  . TRP A 1 289 ? 104.715 140.074 107.373 1.00 55.36  ? 289 TRP U CZ3  1 
ATOM   2006 C CH2  . TRP A 1 289 ? 103.558 140.392 106.651 1.00 54.18  ? 289 TRP U CH2  1 
ATOM   2007 N N    . ILE A 1 290 ? 109.171 140.194 106.204 1.00 53.57  ? 290 ILE U N    1 
ATOM   2008 C CA   . ILE A 1 290 ? 108.974 141.502 106.827 1.00 54.34  ? 290 ILE U CA   1 
ATOM   2009 C C    . ILE A 1 290 ? 109.912 142.523 106.192 1.00 54.30  ? 290 ILE U C    1 
ATOM   2010 O O    . ILE A 1 290 ? 109.547 143.697 106.038 1.00 54.95  ? 290 ILE U O    1 
ATOM   2011 C CB   . ILE A 1 290 ? 109.129 141.447 108.363 1.00 51.85  ? 290 ILE U CB   1 
ATOM   2012 C CG1  . ILE A 1 290 ? 109.283 142.849 108.951 1.00 52.64  ? 290 ILE U CG1  1 
ATOM   2013 C CG2  . ILE A 1 290 ? 110.322 140.645 108.768 1.00 52.91  ? 290 ILE U CG2  1 
ATOM   2014 C CD1  . ILE A 1 290 ? 109.348 142.867 110.459 1.00 56.16  ? 290 ILE U CD1  1 
ATOM   2015 N N    . LEU A 1 291 ? 111.122 142.108 105.799 1.00 57.50  ? 291 LEU U N    1 
ATOM   2016 C CA   . LEU A 1 291 ? 111.999 143.033 105.089 1.00 53.44  ? 291 LEU U CA   1 
ATOM   2017 C C    . LEU A 1 291 ? 111.353 143.492 103.784 1.00 53.17  ? 291 LEU U C    1 
ATOM   2018 O O    . LEU A 1 291 ? 111.364 144.684 103.463 1.00 53.50  ? 291 LEU U O    1 
ATOM   2019 C CB   . LEU A 1 291 ? 113.357 142.392 104.817 1.00 50.12  ? 291 LEU U CB   1 
ATOM   2020 C CG   . LEU A 1 291 ? 114.350 142.330 105.977 1.00 49.00  ? 291 LEU U CG   1 
ATOM   2021 C CD1  . LEU A 1 291 ? 115.734 141.986 105.463 1.00 52.82  ? 291 LEU U CD1  1 
ATOM   2022 C CD2  . LEU A 1 291 ? 114.374 143.669 106.688 1.00 49.90  ? 291 LEU U CD2  1 
ATOM   2023 N N    . ARG A 1 292 ? 110.797 142.549 103.014 1.00 66.45  ? 292 ARG U N    1 
ATOM   2024 C CA   . ARG A 1 292 ? 110.134 142.929 101.766 1.00 66.97  ? 292 ARG U CA   1 
ATOM   2025 C C    . ARG A 1 292 ? 109.009 143.927 102.012 1.00 67.13  ? 292 ARG U C    1 
ATOM   2026 O O    . ARG A 1 292 ? 108.889 144.933 101.303 1.00 66.29  ? 292 ARG U O    1 
ATOM   2027 C CB   . ARG A 1 292 ? 109.595 141.715 101.006 1.00 67.43  ? 292 ARG U CB   1 
ATOM   2028 C CG   . ARG A 1 292 ? 110.630 140.762 100.435 1.00 68.69  ? 292 ARG U CG   1 
ATOM   2029 C CD   . ARG A 1 292 ? 109.929 139.595 99.743  1.00 69.98  ? 292 ARG U CD   1 
ATOM   2030 N NE   . ARG A 1 292 ? 110.857 138.647 99.139  1.00 72.56  ? 292 ARG U NE   1 
ATOM   2031 C CZ   . ARG A 1 292 ? 111.458 137.664 99.791  1.00 72.50  ? 292 ARG U CZ   1 
ATOM   2032 N NH1  . ARG A 1 292 ? 111.457 137.613 101.111 1.00 70.25  ? 292 ARG U NH1  1 
ATOM   2033 N NH2  . ARG A 1 292 ? 112.150 136.756 99.107  1.00 71.29  ? 292 ARG U NH2  1 
ATOM   2034 N N    . LYS A 1 293 ? 108.156 143.656 103.007 1.00 74.21  ? 293 LYS U N    1 
ATOM   2035 C CA   . LYS A 1 293 ? 107.015 144.538 103.256 1.00 76.45  ? 293 LYS U CA   1 
ATOM   2036 C C    . LYS A 1 293 ? 107.440 145.959 103.612 1.00 74.85  ? 293 LYS U C    1 
ATOM   2037 O O    . LYS A 1 293 ? 106.817 146.927 103.159 1.00 75.63  ? 293 LYS U O    1 
ATOM   2038 C CB   . LYS A 1 293 ? 106.133 143.959 104.366 1.00 75.65  ? 293 LYS U CB   1 
ATOM   2039 C CG   . LYS A 1 293 ? 104.928 144.826 104.701 1.00 74.29  ? 293 LYS U CG   1 
ATOM   2040 C CD   . LYS A 1 293 ? 104.006 144.995 103.503 1.00 75.20  ? 293 LYS U CD   1 
ATOM   2041 C CE   . LYS A 1 293 ? 103.373 143.678 103.094 1.00 74.80  ? 293 LYS U CE   1 
ATOM   2042 N NZ   . LYS A 1 293 ? 102.498 143.139 104.170 1.00 74.40  ? 293 LYS U NZ   1 
ATOM   2043 N N    . MET A 1 294 ? 108.492 146.116 104.419 1.00 79.04  ? 294 MET U N    1 
ATOM   2044 C CA   . MET A 1 294 ? 108.891 147.454 104.853 1.00 78.48  ? 294 MET U CA   1 
ATOM   2045 C C    . MET A 1 294 ? 109.432 148.325 103.725 1.00 81.12  ? 294 MET U C    1 
ATOM   2046 O O    . MET A 1 294 ? 109.644 149.522 103.952 1.00 81.15  ? 294 MET U O    1 
ATOM   2047 C CB   . MET A 1 294 ? 109.927 147.370 105.974 1.00 78.22  ? 294 MET U CB   1 
ATOM   2048 C CG   . MET A 1 294 ? 109.337 147.049 107.337 1.00 79.35  ? 294 MET U CG   1 
ATOM   2049 S SD   . MET A 1 294 ? 110.574 146.488 108.521 1.00 87.35  ? 294 MET U SD   1 
ATOM   2050 C CE   . MET A 1 294 ? 111.113 148.049 109.212 1.00 79.35  ? 294 MET U CE   1 
ATOM   2051 N N    . ASP A 1 295 ? 109.643 147.771 102.534 1.00 86.56  ? 295 ASP U N    1 
ATOM   2052 C CA   . ASP A 1 295 ? 110.257 148.496 101.418 1.00 84.90  ? 295 ASP U CA   1 
ATOM   2053 C C    . ASP A 1 295 ? 111.551 149.192 101.832 1.00 85.95  ? 295 ASP U C    1 
ATOM   2054 O O    . ASP A 1 295 ? 112.415 149.462 100.996 1.00 87.11  ? 295 ASP U O    1 
ATOM   2055 C CB   . ASP A 1 295 ? 109.279 149.523 100.837 1.00 84.81  ? 295 ASP U CB   1 
ATOM   2056 C CG   . ASP A 1 295 ? 108.062 148.879 100.203 1.00 87.99  ? 295 ASP U CG   1 
ATOM   2057 O OD1  . ASP A 1 295 ? 107.957 147.635 100.236 1.00 88.12  ? 295 ASP U OD1  1 
ATOM   2058 O OD2  . ASP A 1 295 ? 107.211 149.618 99.668  1.00 87.78  ? 295 ASP U OD2  1 
ATOM   2059 N N    . ASN B 1 14  ? 124.176 102.807 101.031 1.00 48.19  ? 14  ASN A N    1 
ATOM   2060 C CA   . ASN B 1 14  ? 124.856 101.975 102.015 1.00 50.98  ? 14  ASN A CA   1 
ATOM   2061 C C    . ASN B 1 14  ? 126.031 102.713 102.645 1.00 54.03  ? 14  ASN A C    1 
ATOM   2062 O O    . ASN B 1 14  ? 126.458 102.389 103.754 1.00 58.54  ? 14  ASN A O    1 
ATOM   2063 C CB   . ASN B 1 14  ? 125.337 100.672 101.371 1.00 50.72  ? 14  ASN A CB   1 
ATOM   2064 C CG   . ASN B 1 14  ? 125.718 99.622  102.396 1.00 51.34  ? 14  ASN A CG   1 
ATOM   2065 O OD1  . ASN B 1 14  ? 125.347 99.712  103.566 1.00 55.08  ? 14  ASN A OD1  1 
ATOM   2066 N ND2  . ASN B 1 14  ? 126.462 98.613  101.957 1.00 50.28  ? 14  ASN A ND2  1 
ATOM   2067 N N    . GLU B 1 15  ? 126.548 103.715 101.932 1.00 52.60  ? 15  GLU A N    1 
ATOM   2068 C CA   . GLU B 1 15  ? 127.630 104.529 102.474 1.00 51.84  ? 15  GLU A CA   1 
ATOM   2069 C C    . GLU B 1 15  ? 127.166 105.357 103.667 1.00 57.36  ? 15  GLU A C    1 
ATOM   2070 O O    . GLU B 1 15  ? 127.888 105.477 104.665 1.00 60.40  ? 15  GLU A O    1 
ATOM   2071 C CB   . GLU B 1 15  ? 128.197 105.432 101.382 1.00 51.79  ? 15  GLU A CB   1 
ATOM   2072 C CG   . GLU B 1 15  ? 129.355 106.307 101.829 1.00 58.41  ? 15  GLU A CG   1 
ATOM   2073 C CD   . GLU B 1 15  ? 130.006 107.045 100.676 1.00 66.22  ? 15  GLU A CD   1 
ATOM   2074 O OE1  . GLU B 1 15  ? 129.678 106.736 99.510  1.00 64.16  ? 15  GLU A OE1  1 
ATOM   2075 O OE2  . GLU B 1 15  ? 130.848 107.931 100.933 1.00 65.21  ? 15  GLU A OE2  1 
ATOM   2076 N N    . ASP B 1 16  ? 125.966 105.937 103.584 1.00 49.00  ? 16  ASP A N    1 
ATOM   2077 C CA   . ASP B 1 16  ? 125.457 106.744 104.689 1.00 45.43  ? 16  ASP A CA   1 
ATOM   2078 C C    . ASP B 1 16  ? 125.215 105.901 105.934 1.00 50.47  ? 16  ASP A C    1 
ATOM   2079 O O    . ASP B 1 16  ? 125.542 106.325 107.050 1.00 54.53  ? 16  ASP A O    1 
ATOM   2080 C CB   . ASP B 1 16  ? 124.171 107.454 104.264 1.00 48.88  ? 16  ASP A CB   1 
ATOM   2081 C CG   . ASP B 1 16  ? 124.371 108.346 103.054 1.00 55.57  ? 16  ASP A CG   1 
ATOM   2082 O OD1  . ASP B 1 16  ? 125.488 108.877 102.883 1.00 59.75  ? 16  ASP A OD1  1 
ATOM   2083 O OD2  . ASP B 1 16  ? 123.411 108.515 102.275 1.00 55.64  ? 16  ASP A OD2  1 
ATOM   2084 N N    . ASN B 1 17  ? 124.643 104.704 105.766 1.00 42.62  ? 17  ASN A N    1 
ATOM   2085 C CA   . ASN B 1 17  ? 124.428 103.821 106.908 1.00 44.43  ? 17  ASN A CA   1 
ATOM   2086 C C    . ASN B 1 17  ? 125.750 103.391 107.533 1.00 46.79  ? 17  ASN A C    1 
ATOM   2087 O O    . ASN B 1 17  ? 125.880 103.345 108.765 1.00 49.39  ? 17  ASN A O    1 
ATOM   2088 C CB   . ASN B 1 17  ? 123.617 102.600 106.479 1.00 47.08  ? 17  ASN A CB   1 
ATOM   2089 C CG   . ASN B 1 17  ? 122.275 102.972 105.879 1.00 50.07  ? 17  ASN A CG   1 
ATOM   2090 O OD1  . ASN B 1 17  ? 121.751 104.057 106.125 1.00 50.59  ? 17  ASN A OD1  1 
ATOM   2091 N ND2  . ASN B 1 17  ? 121.712 102.068 105.087 1.00 50.71  ? 17  ASN A ND2  1 
ATOM   2092 N N    . ALA B 1 18  ? 126.740 103.071 106.697 1.00 37.50  ? 18  ALA A N    1 
ATOM   2093 C CA   . ALA B 1 18  ? 128.051 102.687 107.213 1.00 37.22  ? 18  ALA A CA   1 
ATOM   2094 C C    . ALA B 1 18  ? 128.695 103.831 107.982 1.00 38.95  ? 18  ALA A C    1 
ATOM   2095 O O    . ALA B 1 18  ? 129.287 103.618 109.045 1.00 41.68  ? 18  ALA A O    1 
ATOM   2096 C CB   . ALA B 1 18  ? 128.953 102.231 106.067 1.00 35.46  ? 18  ALA A CB   1 
ATOM   2097 N N    . ARG B 1 19  ? 128.592 105.052 107.455 1.00 33.18  ? 19  ARG A N    1 
ATOM   2098 C CA   . ARG B 1 19  ? 129.150 106.212 108.146 1.00 30.81  ? 19  ARG A CA   1 
ATOM   2099 C C    . ARG B 1 19  ? 128.454 106.446 109.482 1.00 34.41  ? 19  ARG A C    1 
ATOM   2100 O O    . ARG B 1 19  ? 129.110 106.727 110.494 1.00 43.26  ? 19  ARG A O    1 
ATOM   2101 C CB   . ARG B 1 19  ? 129.036 107.444 107.247 1.00 30.47  ? 19  ARG A CB   1 
ATOM   2102 C CG   . ARG B 1 19  ? 129.526 108.736 107.869 1.00 35.64  ? 19  ARG A CG   1 
ATOM   2103 C CD   . ARG B 1 19  ? 129.891 109.739 106.790 1.00 35.11  ? 19  ARG A CD   1 
ATOM   2104 N NE   . ARG B 1 19  ? 128.710 110.276 106.125 1.00 36.95  ? 19  ARG A NE   1 
ATOM   2105 C CZ   . ARG B 1 19  ? 128.520 110.264 104.813 1.00 38.75  ? 19  ARG A CZ   1 
ATOM   2106 N NH1  . ARG B 1 19  ? 129.421 109.756 103.989 1.00 34.73  ? 19  ARG A NH1  1 
ATOM   2107 N NH2  . ARG B 1 19  ? 127.397 110.778 104.315 1.00 40.19  ? 19  ARG A NH2  1 
ATOM   2108 N N    . PHE B 1 20  ? 127.126 106.314 109.507 1.00 27.79  ? 20  PHE A N    1 
ATOM   2109 C CA   . PHE B 1 20  ? 126.370 106.478 110.745 1.00 24.91  ? 20  PHE A CA   1 
ATOM   2110 C C    . PHE B 1 20  ? 126.800 105.450 111.788 1.00 30.25  ? 20  PHE A C    1 
ATOM   2111 O O    . PHE B 1 20  ? 127.059 105.791 112.951 1.00 35.76  ? 20  PHE A O    1 
ATOM   2112 C CB   . PHE B 1 20  ? 124.876 106.353 110.438 1.00 21.20  ? 20  PHE A CB   1 
ATOM   2113 C CG   . PHE B 1 20  ? 123.979 106.986 111.463 1.00 28.02  ? 20  PHE A CG   1 
ATOM   2114 C CD1  . PHE B 1 20  ? 124.230 108.265 111.927 1.00 30.29  ? 20  PHE A CD1  1 
ATOM   2115 C CD2  . PHE B 1 20  ? 122.877 106.306 111.949 1.00 25.33  ? 20  PHE A CD2  1 
ATOM   2116 C CE1  . PHE B 1 20  ? 123.403 108.851 112.863 1.00 32.16  ? 20  PHE A CE1  1 
ATOM   2117 C CE2  . PHE B 1 20  ? 122.049 106.888 112.888 1.00 22.01  ? 20  PHE A CE2  1 
ATOM   2118 C CZ   . PHE B 1 20  ? 122.311 108.161 113.346 1.00 26.37  ? 20  PHE A CZ   1 
ATOM   2119 N N    . LEU B 1 21  ? 126.902 104.181 111.378 1.00 26.75  ? 21  LEU A N    1 
ATOM   2120 C CA   . LEU B 1 21  ? 127.300 103.120 112.297 1.00 24.16  ? 21  LEU A CA   1 
ATOM   2121 C C    . LEU B 1 21  ? 128.723 103.323 112.808 1.00 30.70  ? 21  LEU A C    1 
ATOM   2122 O O    . LEU B 1 21  ? 128.996 103.145 114.003 1.00 37.08  ? 21  LEU A O    1 
ATOM   2123 C CB   . LEU B 1 21  ? 127.164 101.761 111.609 1.00 24.50  ? 21  LEU A CB   1 
ATOM   2124 C CG   . LEU B 1 21  ? 127.388 100.516 112.466 1.00 27.40  ? 21  LEU A CG   1 
ATOM   2125 C CD1  . LEU B 1 21  ? 126.253 100.327 113.458 1.00 31.40  ? 21  LEU A CD1  1 
ATOM   2126 C CD2  . LEU B 1 21  ? 127.538 99.290  111.581 1.00 23.54  ? 21  LEU A CD2  1 
ATOM   2127 N N    . LEU B 1 22  ? 129.642 103.697 111.914 1.00 27.21  ? 22  LEU A N    1 
ATOM   2128 C CA   . LEU B 1 22  ? 131.026 103.920 112.318 1.00 28.63  ? 22  LEU A CA   1 
ATOM   2129 C C    . LEU B 1 22  ? 131.128 105.062 113.317 1.00 34.28  ? 22  LEU A C    1 
ATOM   2130 O O    . LEU B 1 22  ? 131.846 104.958 114.320 1.00 41.51  ? 22  LEU A O    1 
ATOM   2131 C CB   . LEU B 1 22  ? 131.884 104.206 111.086 1.00 28.61  ? 22  LEU A CB   1 
ATOM   2132 C CG   . LEU B 1 22  ? 133.384 104.406 111.305 1.00 32.80  ? 22  LEU A CG   1 
ATOM   2133 C CD1  . LEU B 1 22  ? 134.045 103.105 111.729 1.00 30.81  ? 22  LEU A CD1  1 
ATOM   2134 C CD2  . LEU B 1 22  ? 134.027 104.953 110.046 1.00 28.32  ? 22  LEU A CD2  1 
ATOM   2135 N N    . LEU B 1 23  ? 130.414 106.163 113.064 1.00 21.41  ? 23  LEU A N    1 
ATOM   2136 C CA   . LEU B 1 23  ? 130.446 107.285 113.992 1.00 18.49  ? 23  LEU A CA   1 
ATOM   2137 C C    . LEU B 1 23  ? 129.879 106.890 115.349 1.00 28.52  ? 23  LEU A C    1 
ATOM   2138 O O    . LEU B 1 23  ? 130.428 107.271 116.392 1.00 33.30  ? 23  LEU A O    1 
ATOM   2139 C CB   . LEU B 1 23  ? 129.684 108.473 113.407 1.00 20.62  ? 23  LEU A CB   1 
ATOM   2140 C CG   . LEU B 1 23  ? 129.742 109.787 114.189 1.00 26.15  ? 23  LEU A CG   1 
ATOM   2141 C CD1  . LEU B 1 23  ? 131.178 110.180 114.484 1.00 25.82  ? 23  LEU A CD1  1 
ATOM   2142 C CD2  . LEU B 1 23  ? 129.029 110.896 113.432 1.00 22.54  ? 23  LEU A CD2  1 
ATOM   2143 N N    . ALA B 1 24  ? 128.788 106.119 115.359 1.00 29.28  ? 24  ALA A N    1 
ATOM   2144 C CA   . ALA B 1 24  ? 128.215 105.679 116.629 1.00 21.50  ? 24  ALA A CA   1 
ATOM   2145 C C    . ALA B 1 24  ? 129.203 104.824 117.416 1.00 32.75  ? 24  ALA A C    1 
ATOM   2146 O O    . ALA B 1 24  ? 129.387 105.016 118.627 1.00 37.84  ? 24  ALA A O    1 
ATOM   2147 C CB   . ALA B 1 24  ? 126.916 104.914 116.379 1.00 17.15  ? 24  ALA A CB   1 
ATOM   2148 N N    . ALA B 1 25  ? 129.856 103.872 116.739 1.00 26.83  ? 25  ALA A N    1 
ATOM   2149 C CA   . ALA B 1 25  ? 130.823 103.015 117.422 1.00 23.00  ? 25  ALA A CA   1 
ATOM   2150 C C    . ALA B 1 25  ? 132.002 103.822 117.964 1.00 28.27  ? 25  ALA A C    1 
ATOM   2151 O O    . ALA B 1 25  ? 132.457 103.595 119.097 1.00 32.13  ? 25  ALA A O    1 
ATOM   2152 C CB   . ALA B 1 25  ? 131.312 101.919 116.475 1.00 19.06  ? 25  ALA A CB   1 
ATOM   2153 N N    . LEU B 1 26  ? 132.506 104.770 117.170 1.00 28.92  ? 26  LEU A N    1 
ATOM   2154 C CA   . LEU B 1 26  ? 133.622 105.591 117.625 1.00 23.88  ? 26  LEU A CA   1 
ATOM   2155 C C    . LEU B 1 26  ? 133.234 106.422 118.837 1.00 24.39  ? 26  LEU A C    1 
ATOM   2156 O O    . LEU B 1 26  ? 134.022 106.562 119.779 1.00 29.95  ? 26  LEU A O    1 
ATOM   2157 C CB   . LEU B 1 26  ? 134.124 106.490 116.493 1.00 27.38  ? 26  LEU A CB   1 
ATOM   2158 C CG   . LEU B 1 26  ? 134.789 105.796 115.304 1.00 23.13  ? 26  LEU A CG   1 
ATOM   2159 C CD1  . LEU B 1 26  ? 135.245 106.816 114.276 1.00 25.19  ? 26  LEU A CD1  1 
ATOM   2160 C CD2  . LEU B 1 26  ? 135.958 104.945 115.766 1.00 19.84  ? 26  LEU A CD2  1 
ATOM   2161 N N    . ILE B 1 27  ? 132.023 106.982 118.835 1.00 17.88  ? 27  ILE A N    1 
ATOM   2162 C CA   . ILE B 1 27  ? 131.578 107.778 119.975 1.00 20.60  ? 27  ILE A CA   1 
ATOM   2163 C C    . ILE B 1 27  ? 131.445 106.904 121.218 1.00 21.87  ? 27  ILE A C    1 
ATOM   2164 O O    . ILE B 1 27  ? 131.778 107.333 122.329 1.00 23.18  ? 27  ILE A O    1 
ATOM   2165 C CB   . ILE B 1 27  ? 130.264 108.511 119.643 1.00 24.97  ? 27  ILE A CB   1 
ATOM   2166 C CG1  . ILE B 1 27  ? 130.502 109.549 118.546 1.00 17.51  ? 27  ILE A CG1  1 
ATOM   2167 C CG2  . ILE B 1 27  ? 129.689 109.183 120.882 1.00 24.55  ? 27  ILE A CG2  1 
ATOM   2168 C CD1  . ILE B 1 27  ? 129.255 110.284 118.116 1.00 13.91  ? 27  ILE A CD1  1 
ATOM   2169 N N    . VAL B 1 28  ? 130.964 105.669 121.057 1.00 25.68  ? 28  VAL A N    1 
ATOM   2170 C CA   . VAL B 1 28  ? 130.837 104.772 122.206 1.00 26.08  ? 28  VAL A CA   1 
ATOM   2171 C C    . VAL B 1 28  ? 132.211 104.474 122.809 1.00 25.70  ? 28  VAL A C    1 
ATOM   2172 O O    . VAL B 1 28  ? 132.402 104.533 124.035 1.00 31.35  ? 28  VAL A O    1 
ATOM   2173 C CB   . VAL B 1 28  ? 130.107 103.479 121.798 1.00 23.31  ? 28  VAL A CB   1 
ATOM   2174 C CG1  . VAL B 1 28  ? 130.230 102.427 122.887 1.00 22.69  ? 28  VAL A CG1  1 
ATOM   2175 C CG2  . VAL B 1 28  ? 128.643 103.767 121.509 1.00 22.44  ? 28  VAL A CG2  1 
ATOM   2176 N N    . LEU B 1 29  ? 133.186 104.152 121.954 1.00 20.49  ? 29  LEU A N    1 
ATOM   2177 C CA   . LEU B 1 29  ? 134.536 103.889 122.456 1.00 22.78  ? 29  LEU A CA   1 
ATOM   2178 C C    . LEU B 1 29  ? 135.134 105.125 123.121 1.00 29.21  ? 29  LEU A C    1 
ATOM   2179 O O    . LEU B 1 29  ? 135.801 105.026 124.163 1.00 32.33  ? 29  LEU A O    1 
ATOM   2180 C CB   . LEU B 1 29  ? 135.437 103.402 121.321 1.00 22.68  ? 29  LEU A CB   1 
ATOM   2181 C CG   . LEU B 1 29  ? 135.106 102.032 120.728 1.00 23.45  ? 29  LEU A CG   1 
ATOM   2182 C CD1  . LEU B 1 29  ? 136.127 101.649 119.673 1.00 19.38  ? 29  LEU A CD1  1 
ATOM   2183 C CD2  . LEU B 1 29  ? 135.044 100.975 121.816 1.00 24.02  ? 29  LEU A CD2  1 
ATOM   2184 N N    . TYR B 1 30  ? 134.906 106.301 122.528 1.00 23.09  ? 30  TYR A N    1 
ATOM   2185 C CA   . TYR B 1 30  ? 135.370 107.556 123.107 1.00 16.95  ? 30  TYR A CA   1 
ATOM   2186 C C    . TYR B 1 30  ? 134.799 107.753 124.504 1.00 20.61  ? 30  TYR A C    1 
ATOM   2187 O O    . TYR B 1 30  ? 135.517 108.128 125.439 1.00 26.85  ? 30  TYR A O    1 
ATOM   2188 C CB   . TYR B 1 30  ? 134.982 108.717 122.187 1.00 15.76  ? 30  TYR A CB   1 
ATOM   2189 C CG   . TYR B 1 30  ? 135.696 110.021 122.459 1.00 24.67  ? 30  TYR A CG   1 
ATOM   2190 C CD1  . TYR B 1 30  ? 137.057 110.156 122.220 1.00 17.47  ? 30  TYR A CD1  1 
ATOM   2191 C CD2  . TYR B 1 30  ? 135.002 111.129 122.929 1.00 19.98  ? 30  TYR A CD2  1 
ATOM   2192 C CE1  . TYR B 1 30  ? 137.708 111.349 122.458 1.00 14.58  ? 30  TYR A CE1  1 
ATOM   2193 C CE2  . TYR B 1 30  ? 135.646 112.326 123.169 1.00 20.06  ? 30  TYR A CE2  1 
ATOM   2194 C CZ   . TYR B 1 30  ? 136.998 112.431 122.932 1.00 16.71  ? 30  TYR A CZ   1 
ATOM   2195 O OH   . TYR B 1 30  ? 137.641 113.624 123.171 1.00 21.97  ? 30  TYR A OH   1 
ATOM   2196 N N    . LEU B 1 31  ? 133.496 107.501 124.661 1.00 16.04  ? 31  LEU A N    1 
ATOM   2197 C CA   . LEU B 1 31  ? 132.854 107.668 125.959 1.00 15.90  ? 31  LEU A CA   1 
ATOM   2198 C C    . LEU B 1 31  ? 133.441 106.717 126.990 1.00 19.08  ? 31  LEU A C    1 
ATOM   2199 O O    . LEU B 1 31  ? 133.703 107.113 128.133 1.00 25.25  ? 31  LEU A O    1 
ATOM   2200 C CB   . LEU B 1 31  ? 131.345 107.452 125.831 1.00 13.65  ? 31  LEU A CB   1 
ATOM   2201 C CG   . LEU B 1 31  ? 130.540 108.533 125.110 1.00 14.13  ? 31  LEU A CG   1 
ATOM   2202 C CD1  . LEU B 1 31  ? 129.062 108.173 125.096 1.00 13.06  ? 31  LEU A CD1  1 
ATOM   2203 C CD2  . LEU B 1 31  ? 130.753 109.890 125.755 1.00 16.25  ? 31  LEU A CD2  1 
ATOM   2204 N N    . LEU B 1 32  ? 133.661 105.454 126.610 1.00 15.99  ? 32  LEU A N    1 
ATOM   2205 C CA   . LEU B 1 32  ? 134.217 104.491 127.558 1.00 17.34  ? 32  LEU A CA   1 
ATOM   2206 C C    . LEU B 1 32  ? 135.615 104.906 128.011 1.00 22.69  ? 32  LEU A C    1 
ATOM   2207 O O    . LEU B 1 32  ? 135.924 104.906 129.216 1.00 24.74  ? 32  LEU A O    1 
ATOM   2208 C CB   . LEU B 1 32  ? 134.244 103.094 126.937 1.00 18.89  ? 32  LEU A CB   1 
ATOM   2209 C CG   . LEU B 1 32  ? 132.900 102.418 126.658 1.00 16.04  ? 32  LEU A CG   1 
ATOM   2210 C CD1  . LEU B 1 32  ? 133.108 101.076 125.980 1.00 18.72  ? 32  LEU A CD1  1 
ATOM   2211 C CD2  . LEU B 1 32  ? 132.104 102.245 127.942 1.00 20.19  ? 32  LEU A CD2  1 
ATOM   2212 N N    . GLY B 1 33  ? 136.476 105.273 127.056 1.00 23.06  ? 33  GLY A N    1 
ATOM   2213 C CA   . GLY B 1 33  ? 137.823 105.686 127.416 1.00 16.97  ? 33  GLY A CA   1 
ATOM   2214 C C    . GLY B 1 33  ? 137.842 106.932 128.285 1.00 22.97  ? 33  GLY A C    1 
ATOM   2215 O O    . GLY B 1 33  ? 138.593 107.013 129.264 1.00 28.07  ? 33  GLY A O    1 
ATOM   2216 N N    . GLY B 1 34  ? 137.013 107.922 127.941 1.00 20.18  ? 34  GLY A N    1 
ATOM   2217 C CA   . GLY B 1 34  ? 136.948 109.128 128.743 1.00 14.81  ? 34  GLY A CA   1 
ATOM   2218 C C    . GLY B 1 34  ? 136.458 108.860 130.152 1.00 23.05  ? 34  GLY A C    1 
ATOM   2219 O O    . GLY B 1 34  ? 136.960 109.449 131.113 1.00 30.21  ? 34  GLY A O    1 
ATOM   2220 N N    . ALA B 1 35  ? 135.471 107.973 130.294 1.00 18.25  ? 35  ALA A N    1 
ATOM   2221 C CA   . ALA B 1 35  ? 134.990 107.611 131.622 1.00 15.49  ? 35  ALA A CA   1 
ATOM   2222 C C    . ALA B 1 35  ? 136.107 106.994 132.455 1.00 16.68  ? 35  ALA A C    1 
ATOM   2223 O O    . ALA B 1 35  ? 136.302 107.355 133.623 1.00 24.65  ? 35  ALA A O    1 
ATOM   2224 C CB   . ALA B 1 35  ? 133.807 106.651 131.509 1.00 15.13  ? 35  ALA A CB   1 
ATOM   2225 N N    . ALA B 1 36  ? 136.865 106.066 131.859 1.00 21.13  ? 36  ALA A N    1 
ATOM   2226 C CA   . ALA B 1 36  ? 137.962 105.440 132.591 1.00 18.72  ? 36  ALA A CA   1 
ATOM   2227 C C    . ALA B 1 36  ? 138.984 106.481 133.041 1.00 26.35  ? 36  ALA A C    1 
ATOM   2228 O O    . ALA B 1 36  ? 139.405 106.499 134.208 1.00 31.18  ? 36  ALA A O    1 
ATOM   2229 C CB   . ALA B 1 36  ? 138.625 104.365 131.732 1.00 16.79  ? 36  ALA A CB   1 
ATOM   2230 N N    . VAL B 1 37  ? 139.372 107.378 132.130 1.00 25.79  ? 37  VAL A N    1 
ATOM   2231 C CA   . VAL B 1 37  ? 140.406 108.358 132.456 1.00 22.04  ? 37  VAL A CA   1 
ATOM   2232 C C    . VAL B 1 37  ? 139.922 109.309 133.549 1.00 24.04  ? 37  VAL A C    1 
ATOM   2233 O O    . VAL B 1 37  ? 140.654 109.602 134.505 1.00 28.80  ? 37  VAL A O    1 
ATOM   2234 C CB   . VAL B 1 37  ? 140.845 109.120 131.193 1.00 21.80  ? 37  VAL A CB   1 
ATOM   2235 C CG1  . VAL B 1 37  ? 141.807 110.237 131.557 1.00 24.44  ? 37  VAL A CG1  1 
ATOM   2236 C CG2  . VAL B 1 37  ? 141.489 108.169 130.200 1.00 21.90  ? 37  VAL A CG2  1 
ATOM   2237 N N    . PHE B 1 38  ? 138.683 109.799 133.431 1.00 21.84  ? 38  PHE A N    1 
ATOM   2238 C CA   . PHE B 1 38  ? 138.169 110.748 134.416 1.00 17.75  ? 38  PHE A CA   1 
ATOM   2239 C C    . PHE B 1 38  ? 138.044 110.103 135.789 1.00 23.04  ? 38  PHE A C    1 
ATOM   2240 O O    . PHE B 1 38  ? 138.359 110.734 136.811 1.00 24.14  ? 38  PHE A O    1 
ATOM   2241 C CB   . PHE B 1 38  ? 136.818 111.302 133.958 1.00 10.59  ? 38  PHE A CB   1 
ATOM   2242 C CG   . PHE B 1 38  ? 136.920 112.556 133.133 1.00 21.85  ? 38  PHE A CG   1 
ATOM   2243 C CD1  . PHE B 1 38  ? 137.348 113.743 133.704 1.00 17.13  ? 38  PHE A CD1  1 
ATOM   2244 C CD2  . PHE B 1 38  ? 136.573 112.553 131.791 1.00 24.63  ? 38  PHE A CD2  1 
ATOM   2245 C CE1  . PHE B 1 38  ? 137.438 114.900 132.953 1.00 20.28  ? 38  PHE A CE1  1 
ATOM   2246 C CE2  . PHE B 1 38  ? 136.661 113.705 131.035 1.00 17.31  ? 38  PHE A CE2  1 
ATOM   2247 C CZ   . PHE B 1 38  ? 137.095 114.880 131.616 1.00 20.78  ? 38  PHE A CZ   1 
ATOM   2248 N N    . SER B 1 39  ? 137.571 108.853 135.844 1.00 27.25  ? 39  SER A N    1 
ATOM   2249 C CA   . SER B 1 39  ? 137.488 108.161 137.128 1.00 24.09  ? 39  SER A CA   1 
ATOM   2250 C C    . SER B 1 39  ? 138.868 108.028 137.759 1.00 27.58  ? 39  SER A C    1 
ATOM   2251 O O    . SER B 1 39  ? 139.057 108.332 138.948 1.00 32.19  ? 39  SER A O    1 
ATOM   2252 C CB   . SER B 1 39  ? 136.839 106.788 136.937 1.00 22.31  ? 39  SER A CB   1 
ATOM   2253 O OG   . SER B 1 39  ? 137.136 105.926 138.020 1.00 31.03  ? 39  SER A OG   1 
ATOM   2254 N N    . ALA B 1 40  ? 139.858 107.606 136.962 1.00 31.53  ? 40  ALA A N    1 
ATOM   2255 C CA   . ALA B 1 40  ? 141.217 107.472 137.480 1.00 25.87  ? 40  ALA A CA   1 
ATOM   2256 C C    . ALA B 1 40  ? 141.761 108.804 137.976 1.00 24.16  ? 40  ALA A C    1 
ATOM   2257 O O    . ALA B 1 40  ? 142.546 108.838 138.929 1.00 31.68  ? 40  ALA A O    1 
ATOM   2258 C CB   . ALA B 1 40  ? 142.138 106.894 136.405 1.00 26.14  ? 40  ALA A CB   1 
ATOM   2259 N N    . LEU B 1 41  ? 141.359 109.908 137.347 1.00 28.54  ? 41  LEU A N    1 
ATOM   2260 C CA   . LEU B 1 41  ? 141.848 111.217 137.768 1.00 20.92  ? 41  LEU A CA   1 
ATOM   2261 C C    . LEU B 1 41  ? 141.171 111.727 139.038 1.00 28.85  ? 41  LEU A C    1 
ATOM   2262 O O    . LEU B 1 41  ? 141.813 112.429 139.827 1.00 29.80  ? 41  LEU A O    1 
ATOM   2263 C CB   . LEU B 1 41  ? 141.660 112.236 136.645 1.00 18.23  ? 41  LEU A CB   1 
ATOM   2264 C CG   . LEU B 1 41  ? 142.658 112.187 135.486 1.00 21.82  ? 41  LEU A CG   1 
ATOM   2265 C CD1  . LEU B 1 41  ? 142.252 113.162 134.395 1.00 20.50  ? 41  LEU A CD1  1 
ATOM   2266 C CD2  . LEU B 1 41  ? 144.069 112.478 135.972 1.00 20.82  ? 41  LEU A CD2  1 
ATOM   2267 N N    . GLU B 1 42  ? 139.894 111.404 139.259 1.00 34.56  ? 42  GLU A N    1 
ATOM   2268 C CA   . GLU B 1 42  ? 139.111 112.112 140.269 1.00 24.31  ? 42  GLU A CA   1 
ATOM   2269 C C    . GLU B 1 42  ? 138.719 111.297 141.500 1.00 27.81  ? 42  GLU A C    1 
ATOM   2270 O O    . GLU B 1 42  ? 138.272 111.898 142.492 1.00 36.11  ? 42  GLU A O    1 
ATOM   2271 C CB   . GLU B 1 42  ? 137.841 112.691 139.629 1.00 29.43  ? 42  GLU A CB   1 
ATOM   2272 C CG   . GLU B 1 42  ? 138.111 113.638 138.472 1.00 22.50  ? 42  GLU A CG   1 
ATOM   2273 C CD   . GLU B 1 42  ? 138.391 115.057 138.931 1.00 33.36  ? 42  GLU A CD   1 
ATOM   2274 O OE1  . GLU B 1 42  ? 137.931 115.430 140.030 1.00 44.51  ? 42  GLU A OE1  1 
ATOM   2275 O OE2  . GLU B 1 42  ? 139.068 115.800 138.193 1.00 39.30  ? 42  GLU A OE2  1 
ATOM   2276 N N    . LEU B 1 43  ? 138.842 109.962 141.468 1.00 30.18  ? 43  LEU A N    1 
ATOM   2277 C CA   . LEU B 1 43  ? 138.283 109.157 142.558 1.00 30.93  ? 43  LEU A CA   1 
ATOM   2278 C C    . LEU B 1 43  ? 138.932 109.473 143.905 1.00 36.37  ? 43  LEU A C    1 
ATOM   2279 O O    . LEU B 1 43  ? 138.235 109.602 144.923 1.00 41.23  ? 43  LEU A O    1 
ATOM   2280 C CB   . LEU B 1 43  ? 138.430 107.671 142.233 1.00 35.12  ? 43  LEU A CB   1 
ATOM   2281 C CG   . LEU B 1 43  ? 137.549 106.699 143.023 1.00 33.81  ? 43  LEU A CG   1 
ATOM   2282 C CD1  . LEU B 1 43  ? 136.165 107.276 143.260 1.00 33.93  ? 43  LEU A CD1  1 
ATOM   2283 C CD2  . LEU B 1 43  ? 137.456 105.361 142.313 1.00 36.19  ? 43  LEU A CD2  1 
ATOM   2284 N N    . ALA B 1 44  ? 140.263 109.586 143.937 1.00 37.74  ? 44  ALA A N    1 
ATOM   2285 C CA   . ALA B 1 44  ? 140.954 109.802 145.206 1.00 35.21  ? 44  ALA A CA   1 
ATOM   2286 C C    . ALA B 1 44  ? 140.578 111.148 145.811 1.00 44.03  ? 44  ALA A C    1 
ATOM   2287 O O    . ALA B 1 44  ? 140.332 111.249 147.022 1.00 50.94  ? 44  ALA A O    1 
ATOM   2288 C CB   . ALA B 1 44  ? 142.466 109.703 145.008 1.00 37.95  ? 44  ALA A CB   1 
ATOM   2289 N N    . HIS B 1 45  ? 140.542 112.193 144.980 1.00 40.46  ? 45  HIS A N    1 
ATOM   2290 C CA   . HIS B 1 45  ? 140.155 113.515 145.456 1.00 37.20  ? 45  HIS A CA   1 
ATOM   2291 C C    . HIS B 1 45  ? 138.754 113.465 146.050 1.00 43.50  ? 45  HIS A C    1 
ATOM   2292 O O    . HIS B 1 45  ? 138.502 114.020 147.128 1.00 47.21  ? 45  HIS A O    1 
ATOM   2293 C CB   . HIS B 1 45  ? 140.235 114.535 144.321 1.00 39.19  ? 45  HIS A CB   1 
ATOM   2294 C CG   . HIS B 1 45  ? 139.819 115.916 144.722 1.00 46.84  ? 45  HIS A CG   1 
ATOM   2295 N ND1  . HIS B 1 45  ? 140.470 116.634 145.703 1.00 49.92  ? 45  HIS A ND1  1 
ATOM   2296 C CD2  . HIS B 1 45  ? 138.819 116.711 144.276 1.00 46.84  ? 45  HIS A CD2  1 
ATOM   2297 C CE1  . HIS B 1 45  ? 139.888 117.811 145.844 1.00 45.75  ? 45  HIS A CE1  1 
ATOM   2298 N NE2  . HIS B 1 45  ? 138.884 117.882 144.990 1.00 43.48  ? 45  HIS A NE2  1 
ATOM   2299 N N    . GLU B 1 46  ? 137.815 112.854 145.319 1.00 43.66  ? 46  GLU A N    1 
ATOM   2300 C CA   . GLU B 1 46  ? 136.442 112.750 145.809 1.00 37.87  ? 46  GLU A CA   1 
ATOM   2301 C C    . GLU B 1 46  ? 136.414 112.106 147.191 1.00 36.21  ? 46  GLU A C    1 
ATOM   2302 O O    . GLU B 1 46  ? 135.790 112.631 148.126 1.00 42.39  ? 46  GLU A O    1 
ATOM   2303 C CB   . GLU B 1 46  ? 135.586 111.958 144.822 1.00 40.29  ? 46  GLU A CB   1 
ATOM   2304 C CG   . GLU B 1 46  ? 134.114 111.896 145.197 1.00 43.59  ? 46  GLU A CG   1 
ATOM   2305 C CD   . GLU B 1 46  ? 133.445 110.623 144.725 1.00 47.72  ? 46  GLU A CD   1 
ATOM   2306 O OE1  . GLU B 1 46  ? 134.148 109.749 144.178 1.00 47.25  ? 46  GLU A OE1  1 
ATOM   2307 O OE2  . GLU B 1 46  ? 132.217 110.493 144.903 1.00 49.91  ? 46  GLU A OE2  1 
ATOM   2308 N N    . ARG B 1 47  ? 137.029 110.925 147.318 1.00 39.02  ? 47  ARG A N    1 
ATOM   2309 C CA   . ARG B 1 47  ? 137.003 110.207 148.590 1.00 41.15  ? 47  ARG A CA   1 
ATOM   2310 C C    . ARG B 1 47  ? 137.598 111.046 149.718 1.00 44.84  ? 47  ARG A C    1 
ATOM   2311 O O    . ARG B 1 47  ? 137.063 111.069 150.838 1.00 50.11  ? 47  ARG A O    1 
ATOM   2312 C CB   . ARG B 1 47  ? 137.745 108.876 148.472 1.00 44.16  ? 47  ARG A CB   1 
ATOM   2313 C CG   . ARG B 1 47  ? 136.856 107.697 148.112 1.00 47.09  ? 47  ARG A CG   1 
ATOM   2314 C CD   . ARG B 1 47  ? 137.648 106.563 147.487 1.00 48.60  ? 47  ARG A CD   1 
ATOM   2315 N NE   . ARG B 1 47  ? 136.787 105.445 147.117 1.00 52.63  ? 47  ARG A NE   1 
ATOM   2316 C CZ   . ARG B 1 47  ? 137.184 104.394 146.413 1.00 54.11  ? 47  ARG A CZ   1 
ATOM   2317 N NH1  . ARG B 1 47  ? 138.429 104.279 145.983 1.00 51.42  ? 47  ARG A NH1  1 
ATOM   2318 N NH2  . ARG B 1 47  ? 136.309 103.429 146.138 1.00 53.39  ? 47  ARG A NH2  1 
ATOM   2319 N N    . GLN B 1 48  ? 138.713 111.733 149.447 1.00 47.76  ? 48  GLN A N    1 
ATOM   2320 C CA   . GLN B 1 48  ? 139.338 112.561 150.478 1.00 48.19  ? 48  GLN A CA   1 
ATOM   2321 C C    . GLN B 1 48  ? 138.419 113.696 150.911 1.00 48.10  ? 48  GLN A C    1 
ATOM   2322 O O    . GLN B 1 48  ? 138.309 113.998 152.108 1.00 49.85  ? 48  GLN A O    1 
ATOM   2323 C CB   . GLN B 1 48  ? 140.666 113.112 149.966 1.00 48.45  ? 48  GLN A CB   1 
ATOM   2324 C CG   . GLN B 1 48  ? 141.775 113.130 151.003 1.00 51.87  ? 48  GLN A CG   1 
ATOM   2325 C CD   . GLN B 1 48  ? 143.135 112.834 150.403 1.00 57.21  ? 48  GLN A CD   1 
ATOM   2326 O OE1  . GLN B 1 48  ? 143.331 112.954 149.191 1.00 56.97  ? 48  GLN A OE1  1 
ATOM   2327 N NE2  . GLN B 1 48  ? 144.085 112.453 151.248 1.00 56.44  ? 48  GLN A NE2  1 
ATOM   2328 N N    . ALA B 1 49  ? 137.743 114.338 149.953 1.00 46.75  ? 49  ALA A N    1 
ATOM   2329 C CA   . ALA B 1 49  ? 136.817 115.413 150.296 1.00 43.58  ? 49  ALA A CA   1 
ATOM   2330 C C    . ALA B 1 49  ? 135.665 114.894 151.149 1.00 46.98  ? 49  ALA A C    1 
ATOM   2331 O O    . ALA B 1 49  ? 135.249 115.552 152.113 1.00 47.80  ? 49  ALA A O    1 
ATOM   2332 C CB   . ALA B 1 49  ? 136.289 116.076 149.025 1.00 41.97  ? 49  ALA A CB   1 
ATOM   2333 N N    . LYS B 1 50  ? 135.134 113.719 150.804 1.00 47.12  ? 50  LYS A N    1 
ATOM   2334 C CA   . LYS B 1 50  ? 134.041 113.151 151.587 1.00 43.25  ? 50  LYS A CA   1 
ATOM   2335 C C    . LYS B 1 50  ? 134.484 112.837 153.011 1.00 44.40  ? 50  LYS A C    1 
ATOM   2336 O O    . LYS B 1 50  ? 133.752 113.102 153.976 1.00 51.51  ? 50  LYS A O    1 
ATOM   2337 C CB   . LYS B 1 50  ? 133.491 111.905 150.897 1.00 42.91  ? 50  LYS A CB   1 
ATOM   2338 C CG   . LYS B 1 50  ? 132.697 112.214 149.638 1.00 44.61  ? 50  LYS A CG   1 
ATOM   2339 C CD   . LYS B 1 50  ? 132.025 110.979 149.071 1.00 44.77  ? 50  LYS A CD   1 
ATOM   2340 C CE   . LYS B 1 50  ? 130.698 111.336 148.420 1.00 47.08  ? 50  LYS A CE   1 
ATOM   2341 N NZ   . LYS B 1 50  ? 130.763 111.245 146.937 1.00 47.46  ? 50  LYS A NZ   1 
ATOM   2342 N N    . GLN B 1 51  ? 135.688 112.275 153.165 1.00 46.74  ? 51  GLN A N    1 
ATOM   2343 C CA   . GLN B 1 51  ? 136.195 111.992 154.507 1.00 45.60  ? 51  GLN A CA   1 
ATOM   2344 C C    . GLN B 1 51  ? 136.373 113.279 155.307 1.00 48.38  ? 51  GLN A C    1 
ATOM   2345 O O    . GLN B 1 51  ? 136.062 113.325 156.507 1.00 53.49  ? 51  GLN A O    1 
ATOM   2346 C CB   . GLN B 1 51  ? 137.509 111.219 154.420 1.00 47.31  ? 51  GLN A CB   1 
ATOM   2347 C CG   . GLN B 1 51  ? 138.233 111.079 155.748 1.00 50.83  ? 51  GLN A CG   1 
ATOM   2348 C CD   . GLN B 1 51  ? 139.613 110.472 155.596 1.00 57.63  ? 51  GLN A CD   1 
ATOM   2349 O OE1  . GLN B 1 51  ? 140.084 110.243 154.483 1.00 60.21  ? 51  GLN A OE1  1 
ATOM   2350 N NE2  . GLN B 1 51  ? 140.268 110.209 156.721 1.00 52.21  ? 51  GLN A NE2  1 
ATOM   2351 N N    . ARG B 1 52  ? 136.875 114.334 154.659 1.00 48.92  ? 52  ARG A N    1 
ATOM   2352 C CA   . ARG B 1 52  ? 137.049 115.608 155.351 1.00 47.21  ? 52  ARG A CA   1 
ATOM   2353 C C    . ARG B 1 52  ? 135.706 116.166 155.812 1.00 48.65  ? 52  ARG A C    1 
ATOM   2354 O O    . ARG B 1 52  ? 135.582 116.658 156.943 1.00 51.77  ? 52  ARG A O    1 
ATOM   2355 C CB   . ARG B 1 52  ? 137.756 116.600 154.429 1.00 44.30  ? 52  ARG A CB   1 
ATOM   2356 C CG   . ARG B 1 52  ? 137.859 118.010 154.970 1.00 45.55  ? 52  ARG A CG   1 
ATOM   2357 C CD   . ARG B 1 52  ? 139.087 118.702 154.411 1.00 46.70  ? 52  ARG A CD   1 
ATOM   2358 N NE   . ARG B 1 52  ? 138.997 118.837 152.962 1.00 50.98  ? 52  ARG A NE   1 
ATOM   2359 C CZ   . ARG B 1 52  ? 139.855 118.302 152.104 1.00 51.99  ? 52  ARG A CZ   1 
ATOM   2360 N NH1  . ARG B 1 52  ? 140.891 117.591 152.516 1.00 48.24  ? 52  ARG A NH1  1 
ATOM   2361 N NH2  . ARG B 1 52  ? 139.665 118.485 150.801 1.00 49.04  ? 52  ARG A NH2  1 
ATOM   2362 N N    . TRP B 1 53  ? 134.685 116.085 154.953 1.00 47.23  ? 53  TRP A N    1 
ATOM   2363 C CA   . TRP B 1 53  ? 133.356 116.544 155.349 1.00 42.94  ? 53  TRP A CA   1 
ATOM   2364 C C    . TRP B 1 53  ? 132.827 115.742 156.529 1.00 40.74  ? 53  TRP A C    1 
ATOM   2365 O O    . TRP B 1 53  ? 132.203 116.303 157.438 1.00 44.18  ? 53  TRP A O    1 
ATOM   2366 C CB   . TRP B 1 53  ? 132.371 116.462 154.186 1.00 41.92  ? 53  TRP A CB   1 
ATOM   2367 C CG   . TRP B 1 53  ? 130.944 116.388 154.667 1.00 40.36  ? 53  TRP A CG   1 
ATOM   2368 C CD1  . TRP B 1 53  ? 130.092 115.330 154.536 1.00 43.70  ? 53  TRP A CD1  1 
ATOM   2369 C CD2  . TRP B 1 53  ? 130.229 117.388 155.411 1.00 43.17  ? 53  TRP A CD2  1 
ATOM   2370 N NE1  . TRP B 1 53  ? 128.882 115.619 155.121 1.00 41.86  ? 53  TRP A NE1  1 
ATOM   2371 C CE2  . TRP B 1 53  ? 128.943 116.874 155.669 1.00 42.49  ? 53  TRP A CE2  1 
ATOM   2372 C CE3  . TRP B 1 53  ? 130.548 118.669 155.873 1.00 42.86  ? 53  TRP A CE3  1 
ATOM   2373 C CZ2  . TRP B 1 53  ? 127.974 117.597 156.364 1.00 40.67  ? 53  TRP A CZ2  1 
ATOM   2374 C CZ3  . TRP B 1 53  ? 129.585 119.386 156.561 1.00 41.71  ? 53  TRP A CZ3  1 
ATOM   2375 C CH2  . TRP B 1 53  ? 128.316 118.847 156.799 1.00 37.46  ? 53  TRP A CH2  1 
ATOM   2376 N N    . GLU B 1 54  ? 133.057 114.428 156.531 1.00 52.55  ? 54  GLU A N    1 
ATOM   2377 C CA   . GLU B 1 54  ? 132.498 113.616 157.606 1.00 50.00  ? 54  GLU A CA   1 
ATOM   2378 C C    . GLU B 1 54  ? 133.193 113.933 158.922 1.00 52.57  ? 54  GLU A C    1 
ATOM   2379 O O    . GLU B 1 54  ? 132.547 113.995 159.978 1.00 56.40  ? 54  GLU A O    1 
ATOM   2380 C CB   . GLU B 1 54  ? 132.622 112.131 157.262 1.00 50.99  ? 54  GLU A CB   1 
ATOM   2381 C CG   . GLU B 1 54  ? 131.428 111.285 157.681 1.00 55.90  ? 54  GLU A CG   1 
ATOM   2382 C CD   . GLU B 1 54  ? 131.486 110.865 159.138 1.00 62.55  ? 54  GLU A CD   1 
ATOM   2383 O OE1  . GLU B 1 54  ? 132.523 111.105 159.788 1.00 60.55  ? 54  GLU A OE1  1 
ATOM   2384 O OE2  . GLU B 1 54  ? 130.489 110.300 159.634 1.00 62.04  ? 54  GLU A OE2  1 
ATOM   2385 N N    . GLU B 1 55  ? 134.502 114.188 158.872 1.00 55.75  ? 55  GLU A N    1 
ATOM   2386 C CA   . GLU B 1 55  ? 135.217 114.582 160.081 1.00 53.92  ? 55  GLU A CA   1 
ATOM   2387 C C    . GLU B 1 55  ? 134.718 115.927 160.597 1.00 55.71  ? 55  GLU A C    1 
ATOM   2388 O O    . GLU B 1 55  ? 134.517 116.102 161.806 1.00 55.08  ? 55  GLU A O    1 
ATOM   2389 C CB   . GLU B 1 55  ? 136.722 114.626 159.813 1.00 52.34  ? 55  GLU A CB   1 
ATOM   2390 C CG   . GLU B 1 55  ? 137.544 115.173 160.967 1.00 58.03  ? 55  GLU A CG   1 
ATOM   2391 C CD   . GLU B 1 55  ? 137.584 114.230 162.153 1.00 62.19  ? 55  GLU A CD   1 
ATOM   2392 O OE1  . GLU B 1 55  ? 137.287 113.029 161.976 1.00 62.80  ? 55  GLU A OE1  1 
ATOM   2393 O OE2  . GLU B 1 55  ? 137.915 114.689 163.267 1.00 61.97  ? 55  GLU A OE2  1 
ATOM   2394 N N    . ARG B 1 56  ? 134.507 116.889 159.694 1.00 57.52  ? 56  ARG A N    1 
ATOM   2395 C CA   . ARG B 1 56  ? 134.009 118.199 160.113 1.00 49.35  ? 56  ARG A CA   1 
ATOM   2396 C C    . ARG B 1 56  ? 132.623 118.095 160.737 1.00 52.71  ? 56  ARG A C    1 
ATOM   2397 O O    . ARG B 1 56  ? 132.344 118.729 161.765 1.00 55.24  ? 56  ARG A O    1 
ATOM   2398 C CB   . ARG B 1 56  ? 133.992 119.159 158.924 1.00 46.44  ? 56  ARG A CB   1 
ATOM   2399 C CG   . ARG B 1 56  ? 135.350 119.741 158.577 1.00 49.61  ? 56  ARG A CG   1 
ATOM   2400 C CD   . ARG B 1 56  ? 135.296 120.508 157.271 1.00 50.63  ? 56  ARG A CD   1 
ATOM   2401 N NE   . ARG B 1 56  ? 136.581 121.112 156.940 1.00 51.72  ? 56  ARG A NE   1 
ATOM   2402 C CZ   . ARG B 1 56  ? 136.883 121.632 155.759 1.00 52.86  ? 56  ARG A CZ   1 
ATOM   2403 N NH1  . ARG B 1 56  ? 136.012 121.633 154.763 1.00 51.41  ? 56  ARG A NH1  1 
ATOM   2404 N NH2  . ARG B 1 56  ? 138.085 122.172 155.574 1.00 53.90  ? 56  ARG A NH2  1 
ATOM   2405 N N    . LEU B 1 57  ? 131.735 117.306 160.124 1.00 51.45  ? 57  LEU A N    1 
ATOM   2406 C CA   . LEU B 1 57  ? 130.393 117.138 160.670 1.00 48.76  ? 57  LEU A CA   1 
ATOM   2407 C C    . LEU B 1 57  ? 130.431 116.483 162.043 1.00 53.44  ? 57  LEU A C    1 
ATOM   2408 O O    . LEU B 1 57  ? 129.715 116.907 162.963 1.00 54.60  ? 57  LEU A O    1 
ATOM   2409 C CB   . LEU B 1 57  ? 129.530 116.317 159.710 1.00 46.39  ? 57  LEU A CB   1 
ATOM   2410 C CG   . LEU B 1 57  ? 128.091 116.071 160.168 1.00 48.60  ? 57  LEU A CG   1 
ATOM   2411 C CD1  . LEU B 1 57  ? 127.194 117.240 159.811 1.00 53.15  ? 57  LEU A CD1  1 
ATOM   2412 C CD2  . LEU B 1 57  ? 127.554 114.791 159.558 1.00 51.76  ? 57  LEU A CD2  1 
ATOM   2413 N N    . ALA B 1 58  ? 131.267 115.454 162.209 1.00 60.89  ? 58  ALA A N    1 
ATOM   2414 C CA   . ALA B 1 58  ? 131.373 114.806 163.511 1.00 60.99  ? 58  ALA A CA   1 
ATOM   2415 C C    . ALA B 1 58  ? 131.903 115.768 164.564 1.00 63.23  ? 58  ALA A C    1 
ATOM   2416 O O    . ALA B 1 58  ? 131.414 115.789 165.702 1.00 61.34  ? 58  ALA A O    1 
ATOM   2417 C CB   . ALA B 1 58  ? 132.264 113.568 163.412 1.00 62.41  ? 58  ALA A CB   1 
ATOM   2418 N N    . GLN B 1 59  ? 132.905 116.577 164.207 1.00 68.46  ? 59  GLN A N    1 
ATOM   2419 C CA   . GLN B 1 59  ? 133.451 117.529 165.168 1.00 65.56  ? 59  GLN A CA   1 
ATOM   2420 C C    . GLN B 1 59  ? 132.416 118.572 165.569 1.00 67.61  ? 59  GLN A C    1 
ATOM   2421 O O    . GLN B 1 59  ? 132.291 118.907 166.753 1.00 67.39  ? 59  GLN A O    1 
ATOM   2422 C CB   . GLN B 1 59  ? 134.696 118.204 164.590 1.00 66.39  ? 59  GLN A CB   1 
ATOM   2423 C CG   . GLN B 1 59  ? 135.827 118.385 165.589 1.00 69.92  ? 59  GLN A CG   1 
ATOM   2424 C CD   . GLN B 1 59  ? 135.468 119.328 166.718 1.00 73.19  ? 59  GLN A CD   1 
ATOM   2425 O OE1  . GLN B 1 59  ? 134.798 120.341 166.509 1.00 70.63  ? 59  GLN A OE1  1 
ATOM   2426 N NE2  . GLN B 1 59  ? 135.910 119.002 167.927 1.00 70.68  ? 59  GLN A NE2  1 
ATOM   2427 N N    . PHE B 1 60  ? 131.658 119.098 164.600 1.00 67.06  ? 60  PHE A N    1 
ATOM   2428 C CA   . PHE B 1 60  ? 130.630 120.077 164.938 1.00 66.30  ? 60  PHE A CA   1 
ATOM   2429 C C    . PHE B 1 60  ? 129.553 119.466 165.823 1.00 65.30  ? 60  PHE A C    1 
ATOM   2430 O O    . PHE B 1 60  ? 129.084 120.103 166.772 1.00 60.36  ? 60  PHE A O    1 
ATOM   2431 C CB   . PHE B 1 60  ? 130.001 120.678 163.684 1.00 62.35  ? 60  PHE A CB   1 
ATOM   2432 C CG   . PHE B 1 60  ? 128.995 121.757 163.986 1.00 62.86  ? 60  PHE A CG   1 
ATOM   2433 C CD1  . PHE B 1 60  ? 129.410 123.059 164.223 1.00 62.76  ? 60  PHE A CD1  1 
ATOM   2434 C CD2  . PHE B 1 60  ? 127.641 121.469 164.054 1.00 63.82  ? 60  PHE A CD2  1 
ATOM   2435 C CE1  . PHE B 1 60  ? 128.494 124.051 164.511 1.00 59.59  ? 60  PHE A CE1  1 
ATOM   2436 C CE2  . PHE B 1 60  ? 126.723 122.460 164.342 1.00 59.72  ? 60  PHE A CE2  1 
ATOM   2437 C CZ   . PHE B 1 60  ? 127.149 123.752 164.569 1.00 57.95  ? 60  PHE A CZ   1 
ATOM   2438 N N    . SER B 1 61  ? 129.135 118.232 165.521 1.00 72.32  ? 61  SER A N    1 
ATOM   2439 C CA   . SER B 1 61  ? 128.107 117.587 166.329 1.00 70.47  ? 61  SER A CA   1 
ATOM   2440 C C    . SER B 1 61  ? 128.593 117.337 167.751 1.00 70.19  ? 61  SER A C    1 
ATOM   2441 O O    . SER B 1 61  ? 127.837 117.521 168.710 1.00 69.46  ? 61  SER A O    1 
ATOM   2442 C CB   . SER B 1 61  ? 127.668 116.279 165.672 1.00 70.55  ? 61  SER A CB   1 
ATOM   2443 O OG   . SER B 1 61  ? 126.746 115.584 166.490 1.00 72.64  ? 61  SER A OG   1 
ATOM   2444 N N    . ARG B 1 62  ? 129.849 116.915 167.908 1.00 73.64  ? 62  ARG A N    1 
ATOM   2445 C CA   . ARG B 1 62  ? 130.358 116.615 169.241 1.00 75.37  ? 62  ARG A CA   1 
ATOM   2446 C C    . ARG B 1 62  ? 130.607 117.886 170.049 1.00 75.30  ? 62  ARG A C    1 
ATOM   2447 O O    . ARG B 1 62  ? 130.393 117.902 171.267 1.00 74.86  ? 62  ARG A O    1 
ATOM   2448 C CB   . ARG B 1 62  ? 131.638 115.785 169.144 1.00 75.97  ? 62  ARG A CB   1 
ATOM   2449 C CG   . ARG B 1 62  ? 132.171 115.300 170.484 1.00 75.52  ? 62  ARG A CG   1 
ATOM   2450 C CD   . ARG B 1 62  ? 133.586 114.732 170.386 1.00 75.91  ? 62  ARG A CD   1 
ATOM   2451 N NE   . ARG B 1 62  ? 134.370 115.316 169.300 1.00 78.11  ? 62  ARG A NE   1 
ATOM   2452 C CZ   . ARG B 1 62  ? 134.589 114.729 168.131 1.00 78.00  ? 62  ARG A CZ   1 
ATOM   2453 N NH1  . ARG B 1 62  ? 134.095 113.534 167.856 1.00 75.08  ? 62  ARG A NH1  1 
ATOM   2454 N NH2  . ARG B 1 62  ? 135.321 115.357 167.217 1.00 74.55  ? 62  ARG A NH2  1 
ATOM   2455 N N    . GLY B 1 63  ? 131.059 118.957 169.394 1.00 74.35  ? 63  GLY A N    1 
ATOM   2456 C CA   . GLY B 1 63  ? 131.395 120.169 170.125 1.00 74.98  ? 63  GLY A CA   1 
ATOM   2457 C C    . GLY B 1 63  ? 130.197 120.853 170.760 1.00 75.58  ? 63  GLY A C    1 
ATOM   2458 O O    . GLY B 1 63  ? 130.278 121.331 171.896 1.00 75.54  ? 63  GLY A O    1 
ATOM   2459 N N    . HIS B 1 64  ? 129.076 120.916 170.045 1.00 75.11  ? 64  HIS A N    1 
ATOM   2460 C CA   . HIS B 1 64  ? 127.896 121.635 170.512 1.00 73.32  ? 64  HIS A CA   1 
ATOM   2461 C C    . HIS B 1 64  ? 126.802 120.698 171.020 1.00 73.62  ? 64  HIS A C    1 
ATOM   2462 O O    . HIS B 1 64  ? 125.645 121.117 171.125 1.00 72.13  ? 64  HIS A O    1 
ATOM   2463 C CB   . HIS B 1 64  ? 127.346 122.534 169.404 1.00 74.91  ? 64  HIS A CB   1 
ATOM   2464 C CG   . HIS B 1 64  ? 128.268 123.646 169.017 1.00 73.39  ? 64  HIS A CG   1 
ATOM   2465 N ND1  . HIS B 1 64  ? 129.203 123.527 168.013 1.00 73.20  ? 64  HIS A ND1  1 
ATOM   2466 C CD2  . HIS B 1 64  ? 128.395 124.906 169.503 1.00 72.64  ? 64  HIS A CD2  1 
ATOM   2467 C CE1  . HIS B 1 64  ? 129.868 124.663 167.894 1.00 73.04  ? 64  HIS A CE1  1 
ATOM   2468 N NE2  . HIS B 1 64  ? 129.397 125.516 168.788 1.00 73.69  ? 64  HIS A NE2  1 
ATOM   2469 N N    . GLN B 1 65  ? 127.155 119.449 171.331 1.00 78.65  ? 65  GLN A N    1 
ATOM   2470 C CA   . GLN B 1 65  ? 126.265 118.420 171.874 1.00 78.96  ? 65  GLN A CA   1 
ATOM   2471 C C    . GLN B 1 65  ? 124.884 118.426 171.221 1.00 76.83  ? 65  GLN A C    1 
ATOM   2472 O O    . GLN B 1 65  ? 123.865 118.283 171.904 1.00 72.98  ? 65  GLN A O    1 
ATOM   2473 C CB   . GLN B 1 65  ? 126.142 118.557 173.401 1.00 76.91  ? 65  GLN A CB   1 
ATOM   2474 C CG   . GLN B 1 65  ? 125.562 119.866 173.928 1.00 78.55  ? 65  GLN A CG   1 
ATOM   2475 C CD   . GLN B 1 65  ? 125.593 119.955 175.442 1.00 81.63  ? 65  GLN A CD   1 
ATOM   2476 O OE1  . GLN B 1 65  ? 126.089 119.054 176.118 1.00 79.89  ? 65  GLN A OE1  1 
ATOM   2477 N NE2  . GLN B 1 65  ? 125.058 121.043 175.980 1.00 81.00  ? 65  GLN A NE2  1 
ATOM   2478 N N    . LEU B 1 66  ? 124.844 118.570 169.899 1.00 76.28  ? 66  LEU A N    1 
ATOM   2479 C CA   . LEU B 1 66  ? 123.598 118.489 169.157 1.00 74.08  ? 66  LEU A CA   1 
ATOM   2480 C C    . LEU B 1 66  ? 123.326 117.044 168.747 1.00 75.34  ? 66  LEU A C    1 
ATOM   2481 O O    . LEU B 1 66  ? 124.087 116.125 169.060 1.00 76.93  ? 66  LEU A O    1 
ATOM   2482 C CB   . LEU B 1 66  ? 123.640 119.410 167.939 1.00 70.91  ? 66  LEU A CB   1 
ATOM   2483 C CG   . LEU B 1 66  ? 123.620 120.915 168.219 1.00 72.81  ? 66  LEU A CG   1 
ATOM   2484 C CD1  . LEU B 1 66  ? 123.743 121.699 166.923 1.00 72.51  ? 66  LEU A CD1  1 
ATOM   2485 C CD2  . LEU B 1 66  ? 122.357 121.306 168.967 1.00 74.34  ? 66  LEU A CD2  1 
ATOM   2486 N N    . SER B 1 67  ? 122.211 116.851 168.035 1.00 75.40  ? 67  SER A N    1 
ATOM   2487 C CA   . SER B 1 67  ? 121.855 115.498 167.536 1.00 73.46  ? 67  SER A CA   1 
ATOM   2488 C C    . SER B 1 67  ? 121.937 115.496 166.007 1.00 76.01  ? 67  SER A C    1 
ATOM   2489 O O    . SER B 1 67  ? 121.826 116.586 165.409 1.00 78.30  ? 67  SER A O    1 
ATOM   2490 C CB   . SER B 1 67  ? 120.486 115.088 168.009 1.00 73.12  ? 67  SER A CB   1 
ATOM   2491 O OG   . SER B 1 67  ? 120.134 113.813 167.490 1.00 76.39  ? 67  SER A OG   1 
ATOM   2492 N N    . ARG B 1 68  ? 122.118 114.319 165.403 1.00 75.10  ? 68  ARG A N    1 
ATOM   2493 C CA   . ARG B 1 68  ? 122.273 114.235 163.926 1.00 73.92  ? 68  ARG A CA   1 
ATOM   2494 C C    . ARG B 1 68  ? 120.945 114.579 163.245 1.00 74.85  ? 68  ARG A C    1 
ATOM   2495 O O    . ARG B 1 68  ? 120.981 115.303 162.233 1.00 76.39  ? 68  ARG A O    1 
ATOM   2496 C CB   . ARG B 1 68  ? 122.751 112.837 163.521 1.00 74.52  ? 68  ARG A CB   1 
ATOM   2497 C CG   . ARG B 1 68  ? 124.097 112.446 164.114 1.00 73.87  ? 68  ARG A CG   1 
ATOM   2498 C CD   . ARG B 1 68  ? 125.198 113.433 163.772 1.00 72.07  ? 68  ARG A CD   1 
ATOM   2499 N NE   . ARG B 1 68  ? 126.432 113.145 164.490 1.00 74.86  ? 68  ARG A NE   1 
ATOM   2500 C CZ   . ARG B 1 68  ? 127.596 112.877 163.911 1.00 75.82  ? 68  ARG A CZ   1 
ATOM   2501 N NH1  . ARG B 1 68  ? 128.650 112.582 164.650 1.00 73.99  ? 68  ARG A NH1  1 
ATOM   2502 N NH2  . ARG B 1 68  ? 127.704 112.911 162.594 1.00 74.53  ? 68  ARG A NH2  1 
ATOM   2503 N N    . ASP B 1 69  ? 119.820 114.089 163.777 1.00 73.89  ? 69  ASP A N    1 
ATOM   2504 C CA   . ASP B 1 69  ? 118.541 114.315 163.107 1.00 74.82  ? 69  ASP A CA   1 
ATOM   2505 C C    . ASP B 1 69  ? 118.226 115.799 163.024 1.00 75.53  ? 69  ASP A C    1 
ATOM   2506 O O    . ASP B 1 69  ? 117.705 116.280 162.007 1.00 76.00  ? 69  ASP A O    1 
ATOM   2507 C CB   . ASP B 1 69  ? 117.427 113.562 163.834 1.00 76.85  ? 69  ASP A CB   1 
ATOM   2508 C CG   . ASP B 1 69  ? 117.613 112.058 163.780 1.00 79.11  ? 69  ASP A CG   1 
ATOM   2509 O OD1  . ASP B 1 69  ? 118.207 111.568 162.797 1.00 78.53  ? 69  ASP A OD1  1 
ATOM   2510 O OD2  . ASP B 1 69  ? 117.163 111.369 164.719 1.00 78.97  ? 69  ASP A OD2  1 
ATOM   2511 N N    . GLU B 1 70  ? 118.523 116.542 164.091 1.00 68.19  ? 70  GLU A N    1 
ATOM   2512 C CA   . GLU B 1 70  ? 118.296 117.981 164.082 1.00 67.06  ? 70  GLU A CA   1 
ATOM   2513 C C    . GLU B 1 70  ? 119.156 118.644 163.015 1.00 68.84  ? 70  GLU A C    1 
ATOM   2514 O O    . GLU B 1 70  ? 118.692 119.534 162.292 1.00 69.46  ? 70  GLU A O    1 
ATOM   2515 C CB   . GLU B 1 70  ? 118.588 118.569 165.460 1.00 66.46  ? 70  GLU A CB   1 
ATOM   2516 C CG   . GLU B 1 70  ? 117.901 117.837 166.597 1.00 68.71  ? 70  GLU A CG   1 
ATOM   2517 C CD   . GLU B 1 70  ? 118.261 118.403 167.955 1.00 72.43  ? 70  GLU A CD   1 
ATOM   2518 O OE1  . GLU B 1 70  ? 118.937 119.452 167.999 1.00 75.17  ? 70  GLU A OE1  1 
ATOM   2519 O OE2  . GLU B 1 70  ? 117.865 117.803 168.974 1.00 71.19  ? 70  GLU A OE2  1 
ATOM   2520 N N    . LEU B 1 71  ? 120.416 118.218 162.908 1.00 60.49  ? 71  LEU A N    1 
ATOM   2521 C CA   . LEU B 1 71  ? 121.293 118.753 161.876 1.00 58.94  ? 71  LEU A CA   1 
ATOM   2522 C C    . LEU B 1 71  ? 120.794 118.387 160.484 1.00 57.87  ? 71  LEU A C    1 
ATOM   2523 O O    . LEU B 1 71  ? 120.889 119.194 159.558 1.00 59.63  ? 71  LEU A O    1 
ATOM   2524 C CB   . LEU B 1 71  ? 122.718 118.249 162.089 1.00 58.06  ? 71  LEU A CB   1 
ATOM   2525 C CG   . LEU B 1 71  ? 123.549 118.994 163.138 1.00 57.77  ? 71  LEU A CG   1 
ATOM   2526 C CD1  . LEU B 1 71  ? 125.025 118.676 162.979 1.00 59.77  ? 71  LEU A CD1  1 
ATOM   2527 C CD2  . LEU B 1 71  ? 123.312 120.495 163.054 1.00 57.13  ? 71  LEU A CD2  1 
ATOM   2528 N N    . ARG B 1 72  ? 120.256 117.172 160.313 1.00 57.02  ? 72  ARG A N    1 
ATOM   2529 C CA   . ARG B 1 72  ? 119.699 116.808 159.013 1.00 56.74  ? 72  ARG A CA   1 
ATOM   2530 C C    . ARG B 1 72  ? 118.516 117.697 158.645 1.00 60.16  ? 72  ARG A C    1 
ATOM   2531 O O    . ARG B 1 72  ? 118.397 118.139 157.497 1.00 61.14  ? 72  ARG A O    1 
ATOM   2532 C CB   . ARG B 1 72  ? 119.276 115.338 159.010 1.00 58.81  ? 72  ARG A CB   1 
ATOM   2533 C CG   . ARG B 1 72  ? 120.423 114.349 159.111 1.00 63.65  ? 72  ARG A CG   1 
ATOM   2534 C CD   . ARG B 1 72  ? 121.056 114.086 157.754 1.00 65.67  ? 72  ARG A CD   1 
ATOM   2535 N NE   . ARG B 1 72  ? 120.106 113.490 156.822 1.00 66.24  ? 72  ARG A NE   1 
ATOM   2536 C CZ   . ARG B 1 72  ? 119.726 112.221 156.847 1.00 65.09  ? 72  ARG A CZ   1 
ATOM   2537 N NH1  . ARG B 1 72  ? 120.207 111.373 157.744 1.00 62.27  ? 72  ARG A NH1  1 
ATOM   2538 N NH2  . ARG B 1 72  ? 118.844 111.790 155.953 1.00 64.02  ? 72  ARG A NH2  1 
ATOM   2539 N N    . GLY B 1 73  ? 117.632 117.971 159.608 1.00 56.30  ? 73  GLY A N    1 
ATOM   2540 C CA   . GLY B 1 73  ? 116.517 118.871 159.338 1.00 53.48  ? 73  GLY A CA   1 
ATOM   2541 C C    . GLY B 1 73  ? 116.964 120.287 159.018 1.00 51.19  ? 73  GLY A C    1 
ATOM   2542 O O    . GLY B 1 73  ? 116.445 120.921 158.091 1.00 52.32  ? 73  GLY A O    1 
ATOM   2543 N N    . PHE B 1 74  ? 117.940 120.792 159.776 1.00 43.38  ? 74  PHE A N    1 
ATOM   2544 C CA   . PHE B 1 74  ? 118.488 122.119 159.514 1.00 38.65  ? 74  PHE A CA   1 
ATOM   2545 C C    . PHE B 1 74  ? 119.103 122.188 158.122 1.00 42.86  ? 74  PHE A C    1 
ATOM   2546 O O    . PHE B 1 74  ? 118.904 123.168 157.392 1.00 42.35  ? 74  PHE A O    1 
ATOM   2547 C CB   . PHE B 1 74  ? 119.516 122.470 160.592 1.00 35.63  ? 74  PHE A CB   1 
ATOM   2548 C CG   . PHE B 1 74  ? 120.011 123.888 160.531 1.00 40.32  ? 74  PHE A CG   1 
ATOM   2549 C CD1  . PHE B 1 74  ? 119.149 124.945 160.771 1.00 37.92  ? 74  PHE A CD1  1 
ATOM   2550 C CD2  . PHE B 1 74  ? 121.340 124.164 160.257 1.00 41.72  ? 74  PHE A CD2  1 
ATOM   2551 C CE1  . PHE B 1 74  ? 119.599 126.248 160.721 1.00 38.68  ? 74  PHE A CE1  1 
ATOM   2552 C CE2  . PHE B 1 74  ? 121.796 125.466 160.207 1.00 41.97  ? 74  PHE A CE2  1 
ATOM   2553 C CZ   . PHE B 1 74  ? 120.924 126.510 160.440 1.00 40.99  ? 74  PHE A CZ   1 
ATOM   2554 N N    . LEU B 1 75  ? 119.844 121.152 157.729 1.00 44.78  ? 75  LEU A N    1 
ATOM   2555 C CA   . LEU B 1 75  ? 120.471 121.140 156.412 1.00 40.17  ? 75  LEU A CA   1 
ATOM   2556 C C    . LEU B 1 75  ? 119.439 121.008 155.301 1.00 42.89  ? 75  LEU A C    1 
ATOM   2557 O O    . LEU B 1 75  ? 119.637 121.559 154.217 1.00 44.90  ? 75  LEU A O    1 
ATOM   2558 C CB   . LEU B 1 75  ? 121.499 120.014 156.327 1.00 38.43  ? 75  LEU A CB   1 
ATOM   2559 C CG   . LEU B 1 75  ? 122.749 120.187 157.192 1.00 35.73  ? 75  LEU A CG   1 
ATOM   2560 C CD1  . LEU B 1 75  ? 123.677 118.991 157.053 1.00 37.31  ? 75  LEU A CD1  1 
ATOM   2561 C CD2  . LEU B 1 75  ? 123.474 121.475 156.841 1.00 38.23  ? 75  LEU A CD2  1 
ATOM   2562 N N    . ARG B 1 76  ? 118.344 120.285 155.538 1.00 42.14  ? 76  ARG A N    1 
ATOM   2563 C CA   . ARG B 1 76  ? 117.274 120.232 154.546 1.00 40.58  ? 76  ARG A CA   1 
ATOM   2564 C C    . ARG B 1 76  ? 116.631 121.603 154.357 1.00 44.67  ? 76  ARG A C    1 
ATOM   2565 O O    . ARG B 1 76  ? 116.367 122.030 153.223 1.00 42.59  ? 76  ARG A O    1 
ATOM   2566 C CB   . ARG B 1 76  ? 116.229 119.198 154.968 1.00 39.27  ? 76  ARG A CB   1 
ATOM   2567 C CG   . ARG B 1 76  ? 115.380 118.657 153.834 1.00 47.55  ? 76  ARG A CG   1 
ATOM   2568 C CD   . ARG B 1 76  ? 114.280 117.753 154.362 1.00 48.02  ? 76  ARG A CD   1 
ATOM   2569 N NE   . ARG B 1 76  ? 114.799 116.746 155.279 1.00 46.03  ? 76  ARG A NE   1 
ATOM   2570 C CZ   . ARG B 1 76  ? 115.243 115.552 154.912 1.00 48.75  ? 76  ARG A CZ   1 
ATOM   2571 N NH1  . ARG B 1 76  ? 115.253 115.181 153.643 1.00 47.01  ? 76  ARG A NH1  1 
ATOM   2572 N NH2  . ARG B 1 76  ? 115.696 114.715 155.841 1.00 48.24  ? 76  ARG A NH2  1 
ATOM   2573 N N    . HIS B 1 77  ? 116.380 122.313 155.463 1.00 43.50  ? 77  HIS A N    1 
ATOM   2574 C CA   . HIS B 1 77  ? 115.859 123.674 155.359 1.00 32.82  ? 77  HIS A CA   1 
ATOM   2575 C C    . HIS B 1 77  ? 116.833 124.580 154.612 1.00 37.14  ? 77  HIS A C    1 
ATOM   2576 O O    . HIS B 1 77  ? 116.421 125.400 153.781 1.00 38.72  ? 77  HIS A O    1 
ATOM   2577 C CB   . HIS B 1 77  ? 115.559 124.236 156.748 1.00 33.77  ? 77  HIS A CB   1 
ATOM   2578 C CG   . HIS B 1 77  ? 114.279 123.726 157.335 1.00 39.14  ? 77  HIS A CG   1 
ATOM   2579 N ND1  . HIS B 1 77  ? 113.838 124.087 158.589 1.00 40.35  ? 77  HIS A ND1  1 
ATOM   2580 C CD2  . HIS B 1 77  ? 113.337 122.896 156.830 1.00 39.02  ? 77  HIS A CD2  1 
ATOM   2581 C CE1  . HIS B 1 77  ? 112.687 123.493 158.837 1.00 38.30  ? 77  HIS A CE1  1 
ATOM   2582 N NE2  . HIS B 1 77  ? 112.359 122.765 157.784 1.00 41.87  ? 77  HIS A NE2  1 
ATOM   2583 N N    . TYR B 1 78  ? 118.131 124.440 154.890 1.00 39.52  ? 78  TYR A N    1 
ATOM   2584 C CA   . TYR B 1 78  ? 119.112 125.278 154.213 1.00 34.61  ? 78  TYR A CA   1 
ATOM   2585 C C    . TYR B 1 78  ? 119.216 124.924 152.736 1.00 36.02  ? 78  TYR A C    1 
ATOM   2586 O O    . TYR B 1 78  ? 119.475 125.800 151.908 1.00 47.68  ? 78  TYR A O    1 
ATOM   2587 C CB   . TYR B 1 78  ? 120.480 125.155 154.883 1.00 38.65  ? 78  TYR A CB   1 
ATOM   2588 C CG   . TYR B 1 78  ? 121.543 125.986 154.204 1.00 37.98  ? 78  TYR A CG   1 
ATOM   2589 C CD1  . TYR B 1 78  ? 121.510 127.373 154.273 1.00 36.01  ? 78  TYR A CD1  1 
ATOM   2590 C CD2  . TYR B 1 78  ? 122.564 125.388 153.478 1.00 36.85  ? 78  TYR A CD2  1 
ATOM   2591 C CE1  . TYR B 1 78  ? 122.470 128.140 153.648 1.00 32.52  ? 78  TYR A CE1  1 
ATOM   2592 C CE2  . TYR B 1 78  ? 123.529 126.150 152.851 1.00 40.40  ? 78  TYR A CE2  1 
ATOM   2593 C CZ   . TYR B 1 78  ? 123.476 127.525 152.937 1.00 40.97  ? 78  TYR A CZ   1 
ATOM   2594 O OH   . TYR B 1 78  ? 124.436 128.284 152.314 1.00 44.71  ? 78  TYR A OH   1 
ATOM   2595 N N    . GLU B 1 79  ? 119.033 123.650 152.391 1.00 38.22  ? 79  GLU A N    1 
ATOM   2596 C CA   . GLU B 1 79  ? 118.989 123.249 150.990 1.00 39.32  ? 79  GLU A CA   1 
ATOM   2597 C C    . GLU B 1 79  ? 117.814 123.901 150.280 1.00 42.96  ? 79  GLU A C    1 
ATOM   2598 O O    . GLU B 1 79  ? 117.948 124.389 149.149 1.00 44.41  ? 79  GLU A O    1 
ATOM   2599 C CB   . GLU B 1 79  ? 118.904 121.725 150.889 1.00 40.55  ? 79  GLU A CB   1 
ATOM   2600 C CG   . GLU B 1 79  ? 119.854 121.107 149.885 1.00 47.50  ? 79  GLU A CG   1 
ATOM   2601 C CD   . GLU B 1 79  ? 120.188 119.663 150.218 1.00 50.63  ? 79  GLU A CD   1 
ATOM   2602 O OE1  . GLU B 1 79  ? 119.361 118.778 149.918 1.00 49.19  ? 79  GLU A OE1  1 
ATOM   2603 O OE2  . GLU B 1 79  ? 121.275 119.416 150.782 1.00 53.41  ? 79  GLU A OE2  1 
ATOM   2604 N N    . GLU B 1 80  ? 116.649 123.921 150.934 1.00 42.29  ? 80  GLU A N    1 
ATOM   2605 C CA   . GLU B 1 80  ? 115.496 124.606 150.359 1.00 39.14  ? 80  GLU A CA   1 
ATOM   2606 C C    . GLU B 1 80  ? 115.781 126.094 150.169 1.00 41.61  ? 80  GLU A C    1 
ATOM   2607 O O    . GLU B 1 80  ? 115.460 126.671 149.122 1.00 38.99  ? 80  GLU A O    1 
ATOM   2608 C CB   . GLU B 1 80  ? 114.272 124.407 151.249 1.00 37.81  ? 80  GLU A CB   1 
ATOM   2609 C CG   . GLU B 1 80  ? 113.018 125.097 150.747 1.00 42.14  ? 80  GLU A CG   1 
ATOM   2610 C CD   . GLU B 1 80  ? 111.792 124.755 151.570 1.00 50.31  ? 80  GLU A CD   1 
ATOM   2611 O OE1  . GLU B 1 80  ? 111.897 123.888 152.462 1.00 48.77  ? 80  GLU A OE1  1 
ATOM   2612 O OE2  . GLU B 1 80  ? 110.726 125.355 151.324 1.00 51.96  ? 80  GLU A OE2  1 
ATOM   2613 N N    . ALA B 1 81  ? 116.399 126.725 151.171 1.00 44.29  ? 81  ALA A N    1 
ATOM   2614 C CA   . ALA B 1 81  ? 116.728 128.146 151.066 1.00 36.85  ? 81  ALA A CA   1 
ATOM   2615 C C    . ALA B 1 81  ? 117.715 128.410 149.935 1.00 35.35  ? 81  ALA A C    1 
ATOM   2616 O O    . ALA B 1 81  ? 117.585 129.395 149.202 1.00 39.22  ? 81  ALA A O    1 
ATOM   2617 C CB   . ALA B 1 81  ? 117.292 128.652 152.390 1.00 36.09  ? 81  ALA A CB   1 
ATOM   2618 N N    . THR B 1 82  ? 118.717 127.540 149.787 1.00 40.28  ? 82  THR A N    1 
ATOM   2619 C CA   . THR B 1 82  ? 119.688 127.692 148.707 1.00 39.72  ? 82  THR A CA   1 
ATOM   2620 C C    . THR B 1 82  ? 119.010 127.558 147.353 1.00 43.47  ? 82  THR A C    1 
ATOM   2621 O O    . THR B 1 82  ? 119.317 128.307 146.416 1.00 42.16  ? 82  THR A O    1 
ATOM   2622 C CB   . THR B 1 82  ? 120.808 126.662 148.861 1.00 40.84  ? 82  THR A CB   1 
ATOM   2623 O OG1  . THR B 1 82  ? 121.611 126.991 150.001 1.00 41.33  ? 82  THR A OG1  1 
ATOM   2624 C CG2  . THR B 1 82  ? 121.690 126.632 147.623 1.00 48.02  ? 82  THR A CG2  1 
ATOM   2625 N N    . ARG B 1 83  ? 118.002 126.737 147.148 1.00 50.97  ? 83  ARG A N    1 
ATOM   2626 C CA   . ARG B 1 83  ? 117.349 126.705 145.813 1.00 44.69  ? 83  ARG A CA   1 
ATOM   2627 C C    . ARG B 1 83  ? 116.503 127.948 145.702 1.00 45.53  ? 83  ARG A C    1 
ATOM   2628 O O    . ARG B 1 83  ? 116.278 128.420 144.606 1.00 48.42  ? 83  ARG A O    1 
ATOM   2629 C CB   . ARG B 1 83  ? 116.472 125.473 145.590 1.00 45.53  ? 83  ARG A CB   1 
ATOM   2630 C CG   . ARG B 1 83  ? 115.089 125.500 146.217 1.00 48.85  ? 83  ARG A CG   1 
ATOM   2631 C CD   . ARG B 1 83  ? 114.360 124.202 145.917 1.00 53.91  ? 83  ARG A CD   1 
ATOM   2632 N NE   . ARG B 1 83  ? 115.176 123.010 146.119 1.00 54.81  ? 83  ARG A NE   1 
ATOM   2633 C CZ   . ARG B 1 83  ? 114.923 122.059 147.013 1.00 56.34  ? 83  ARG A CZ   1 
ATOM   2634 N NH1  . ARG B 1 83  ? 113.826 122.110 147.745 1.00 54.04  ? 83  ARG A NH1  1 
ATOM   2635 N NH2  . ARG B 1 83  ? 115.772 121.060 147.177 1.00 48.35  ? 83  ARG A NH2  1 
ATOM   2636 N N    . ALA B 1 84  ? 116.027 128.429 146.841 1.00 48.09  ? 84  ALA A N    1 
ATOM   2637 C CA   . ALA B 1 84  ? 115.318 129.696 146.688 1.00 42.62  ? 84  ALA A CA   1 
ATOM   2638 C C    . ALA B 1 84  ? 116.237 130.798 146.168 1.00 37.45  ? 84  ALA A C    1 
ATOM   2639 O O    . ALA B 1 84  ? 115.805 131.654 145.388 1.00 45.96  ? 84  ALA A O    1 
ATOM   2640 C CB   . ALA B 1 84  ? 114.684 130.110 148.016 1.00 45.03  ? 84  ALA A CB   1 
ATOM   2641 N N    . GLY B 1 85  ? 117.501 130.803 146.591 1.00 41.62  ? 85  GLY A N    1 
ATOM   2642 C CA   . GLY B 1 85  ? 118.431 131.817 146.130 1.00 39.16  ? 85  GLY A CA   1 
ATOM   2643 C C    . GLY B 1 85  ? 119.365 132.378 147.186 1.00 43.25  ? 85  GLY A C    1 
ATOM   2644 O O    . GLY B 1 85  ? 120.213 133.221 146.881 1.00 46.93  ? 85  GLY A O    1 
ATOM   2645 N N    . ILE B 1 86  ? 119.224 131.924 148.428 1.00 45.08  ? 86  ILE A N    1 
ATOM   2646 C CA   . ILE B 1 86  ? 120.033 132.439 149.528 1.00 34.73  ? 86  ILE A CA   1 
ATOM   2647 C C    . ILE B 1 86  ? 121.428 131.831 149.465 1.00 38.76  ? 86  ILE A C    1 
ATOM   2648 O O    . ILE B 1 86  ? 121.586 130.618 149.290 1.00 45.15  ? 86  ILE A O    1 
ATOM   2649 C CB   . ILE B 1 86  ? 119.354 132.141 150.876 1.00 38.81  ? 86  ILE A CB   1 
ATOM   2650 C CG1  . ILE B 1 86  ? 118.216 133.134 151.124 1.00 40.00  ? 86  ILE A CG1  1 
ATOM   2651 C CG2  . ILE B 1 86  ? 120.365 132.154 152.017 1.00 38.99  ? 86  ILE A CG2  1 
ATOM   2652 C CD1  . ILE B 1 86  ? 118.641 134.409 151.821 1.00 42.50  ? 86  ILE A CD1  1 
ATOM   2653 N N    . ARG B 1 87  ? 122.446 132.677 149.608 1.00 48.68  ? 87  ARG A N    1 
ATOM   2654 C CA   . ARG B 1 87  ? 123.843 132.261 149.676 1.00 50.31  ? 87  ARG A CA   1 
ATOM   2655 C C    . ARG B 1 87  ? 124.460 132.778 150.976 1.00 48.57  ? 87  ARG A C    1 
ATOM   2656 O O    . ARG B 1 87  ? 123.803 133.443 151.781 1.00 51.59  ? 87  ARG A O    1 
ATOM   2657 C CB   . ARG B 1 87  ? 124.610 132.772 148.452 1.00 48.31  ? 87  ARG A CB   1 
ATOM   2658 C CG   . ARG B 1 87  ? 125.791 131.921 148.029 1.00 49.33  ? 87  ARG A CG   1 
ATOM   2659 C CD   . ARG B 1 87  ? 125.331 130.621 147.394 1.00 50.48  ? 87  ARG A CD   1 
ATOM   2660 N NE   . ARG B 1 87  ? 124.130 130.797 146.584 1.00 47.17  ? 87  ARG A NE   1 
ATOM   2661 C CZ   . ARG B 1 87  ? 123.729 129.949 145.648 1.00 52.06  ? 87  ARG A CZ   1 
ATOM   2662 N NH1  . ARG B 1 87  ? 124.419 128.857 145.364 1.00 52.22  ? 87  ARG A NH1  1 
ATOM   2663 N NH2  . ARG B 1 87  ? 122.607 130.203 144.980 1.00 49.46  ? 87  ARG A NH2  1 
ATOM   2664 N N    . VAL B 1 88  ? 125.742 132.473 151.179 1.00 53.34  ? 88  VAL A N    1 
ATOM   2665 C CA   . VAL B 1 88  ? 126.433 132.873 152.399 1.00 57.56  ? 88  VAL A CA   1 
ATOM   2666 C C    . VAL B 1 88  ? 127.228 134.170 152.238 1.00 59.33  ? 88  VAL A C    1 
ATOM   2667 O O    . VAL B 1 88  ? 127.468 134.864 153.239 1.00 55.88  ? 88  VAL A O    1 
ATOM   2668 C CB   . VAL B 1 88  ? 127.351 131.727 152.892 1.00 53.69  ? 88  VAL A CB   1 
ATOM   2669 C CG1  . VAL B 1 88  ? 128.184 132.139 154.096 1.00 51.80  ? 88  VAL A CG1  1 
ATOM   2670 C CG2  . VAL B 1 88  ? 126.521 130.508 153.244 1.00 50.03  ? 88  VAL A CG2  1 
ATOM   2671 N N    . ASP B 1 89  ? 127.573 134.557 151.013 1.00 60.32  ? 89  ASP A N    1 
ATOM   2672 C CA   . ASP B 1 89  ? 128.360 135.766 150.763 1.00 58.11  ? 89  ASP A CA   1 
ATOM   2673 C C    . ASP B 1 89  ? 127.612 136.669 149.789 1.00 61.69  ? 89  ASP A C    1 
ATOM   2674 O O    . ASP B 1 89  ? 127.848 136.617 148.580 1.00 68.66  ? 89  ASP A O    1 
ATOM   2675 C CB   . ASP B 1 89  ? 129.757 135.394 150.230 1.00 58.71  ? 89  ASP A CB   1 
ATOM   2676 C CG   . ASP B 1 89  ? 130.605 134.673 151.260 1.00 65.25  ? 89  ASP A CG   1 
ATOM   2677 O OD1  . ASP B 1 89  ? 130.368 134.869 152.471 1.00 67.62  ? 89  ASP A OD1  1 
ATOM   2678 O OD2  . ASP B 1 89  ? 131.510 133.911 150.859 1.00 64.43  ? 89  ASP A OD2  1 
ATOM   2679 N N    . ASN B 1 90  ? 126.701 137.488 150.327 1.00 54.21  ? 90  ASN A N    1 
ATOM   2680 C CA   . ASN B 1 90  ? 126.264 138.747 149.723 1.00 52.66  ? 90  ASN A CA   1 
ATOM   2681 C C    . ASN B 1 90  ? 126.059 138.676 148.213 1.00 55.22  ? 90  ASN A C    1 
ATOM   2682 O O    . ASN B 1 90  ? 126.788 139.325 147.459 1.00 57.57  ? 90  ASN A O    1 
ATOM   2683 C CB   . ASN B 1 90  ? 127.270 139.857 150.037 1.00 57.27  ? 90  ASN A CB   1 
ATOM   2684 C CG   . ASN B 1 90  ? 127.332 140.191 151.513 1.00 61.52  ? 90  ASN A CG   1 
ATOM   2685 O OD1  . ASN B 1 90  ? 126.344 140.054 152.235 1.00 60.75  ? 90  ASN A OD1  1 
ATOM   2686 N ND2  . ASN B 1 90  ? 128.495 140.638 151.969 1.00 57.12  ? 90  ASN A ND2  1 
ATOM   2687 N N    . VAL B 1 91  ? 125.090 137.890 147.760 1.00 43.22  ? 91  VAL A N    1 
ATOM   2688 C CA   . VAL B 1 91  ? 124.781 137.821 146.341 1.00 36.73  ? 91  VAL A CA   1 
ATOM   2689 C C    . VAL B 1 91  ? 123.754 138.889 145.980 1.00 38.96  ? 91  VAL A C    1 
ATOM   2690 O O    . VAL B 1 91  ? 123.018 139.403 146.827 1.00 38.35  ? 91  VAL A O    1 
ATOM   2691 C CB   . VAL B 1 91  ? 124.281 136.419 145.936 1.00 39.64  ? 91  VAL A CB   1 
ATOM   2692 C CG1  . VAL B 1 91  ? 125.459 135.487 145.706 1.00 39.31  ? 91  VAL A CG1  1 
ATOM   2693 C CG2  . VAL B 1 91  ? 123.343 135.866 146.995 1.00 45.08  ? 91  VAL A CG2  1 
ATOM   2694 N N    . ARG B 1 92  ? 123.719 139.231 144.696 1.00 35.94  ? 92  ARG A N    1 
ATOM   2695 C CA   . ARG B 1 92  ? 122.742 140.171 144.178 1.00 30.33  ? 92  ARG A CA   1 
ATOM   2696 C C    . ARG B 1 92  ? 121.338 139.562 144.198 1.00 37.67  ? 92  ARG A C    1 
ATOM   2697 O O    . ARG B 1 92  ? 121.184 138.339 144.153 1.00 47.63  ? 92  ARG A O    1 
ATOM   2698 C CB   . ARG B 1 92  ? 123.121 140.585 142.760 1.00 30.47  ? 92  ARG A CB   1 
ATOM   2699 C CG   . ARG B 1 92  ? 123.049 139.459 141.745 1.00 34.56  ? 92  ARG A CG   1 
ATOM   2700 C CD   . ARG B 1 92  ? 123.637 139.883 140.415 1.00 37.08  ? 92  ARG A CD   1 
ATOM   2701 N NE   . ARG B 1 92  ? 122.785 140.836 139.718 1.00 41.72  ? 92  ARG A NE   1 
ATOM   2702 C CZ   . ARG B 1 92  ? 122.969 141.226 138.465 1.00 37.11  ? 92  ARG A CZ   1 
ATOM   2703 N NH1  . ARG B 1 92  ? 123.972 140.766 137.736 1.00 31.40  ? 92  ARG A NH1  1 
ATOM   2704 N NH2  . ARG B 1 92  ? 122.124 142.099 137.927 1.00 36.44  ? 92  ARG A NH2  1 
ATOM   2705 N N    . PRO B 1 93  ? 120.301 140.392 144.285 1.00 34.81  ? 93  PRO A N    1 
ATOM   2706 C CA   . PRO B 1 93  ? 118.932 139.865 144.290 1.00 26.54  ? 93  PRO A CA   1 
ATOM   2707 C C    . PRO B 1 93  ? 118.560 139.214 142.964 1.00 27.59  ? 93  PRO A C    1 
ATOM   2708 O O    . PRO B 1 93  ? 119.030 139.606 141.894 1.00 37.32  ? 93  PRO A O    1 
ATOM   2709 C CB   . PRO B 1 93  ? 118.073 141.104 144.563 1.00 22.21  ? 93  PRO A CB   1 
ATOM   2710 C CG   . PRO B 1 93  ? 118.919 142.256 144.146 1.00 30.05  ? 93  PRO A CG   1 
ATOM   2711 C CD   . PRO B 1 93  ? 120.327 141.854 144.462 1.00 35.64  ? 93  PRO A CD   1 
ATOM   2712 N N    . ARG B 1 94  ? 117.705 138.201 143.055 1.00 30.79  ? 94  ARG A N    1 
ATOM   2713 C CA   . ARG B 1 94  ? 117.086 137.581 141.894 1.00 30.60  ? 94  ARG A CA   1 
ATOM   2714 C C    . ARG B 1 94  ? 115.821 138.329 141.478 1.00 42.30  ? 94  ARG A C    1 
ATOM   2715 O O    . ARG B 1 94  ? 115.280 139.158 142.212 1.00 50.70  ? 94  ARG A O    1 
ATOM   2716 C CB   . ARG B 1 94  ? 116.758 136.114 142.181 1.00 29.89  ? 94  ARG A CB   1 
ATOM   2717 C CG   . ARG B 1 94  ? 117.864 135.150 141.808 1.00 28.48  ? 94  ARG A CG   1 
ATOM   2718 C CD   . ARG B 1 94  ? 118.884 134.981 142.917 1.00 29.51  ? 94  ARG A CD   1 
ATOM   2719 N NE   . ARG B 1 94  ? 120.066 134.285 142.427 1.00 32.21  ? 94  ARG A NE   1 
ATOM   2720 C CZ   . ARG B 1 94  ? 121.188 134.885 142.058 1.00 34.20  ? 94  ARG A CZ   1 
ATOM   2721 N NH1  . ARG B 1 94  ? 121.344 136.192 142.185 1.00 29.81  ? 94  ARG A NH1  1 
ATOM   2722 N NH2  . ARG B 1 94  ? 122.179 134.155 141.557 1.00 38.35  ? 94  ARG A NH2  1 
ATOM   2723 N N    . TRP B 1 95  ? 115.361 138.023 140.263 1.00 25.64  ? 95  TRP A N    1 
ATOM   2724 C CA   . TRP B 1 95  ? 114.041 138.418 139.762 1.00 19.71  ? 95  TRP A CA   1 
ATOM   2725 C C    . TRP B 1 95  ? 113.771 139.920 139.858 1.00 24.53  ? 95  TRP A C    1 
ATOM   2726 O O    . TRP B 1 95  ? 112.617 140.351 139.775 1.00 37.45  ? 95  TRP A O    1 
ATOM   2727 C CB   . TRP B 1 95  ? 112.927 137.629 140.461 1.00 12.21  ? 95  TRP A CB   1 
ATOM   2728 C CG   . TRP B 1 95  ? 113.079 136.141 140.320 1.00 18.32  ? 95  TRP A CG   1 
ATOM   2729 C CD1  . TRP B 1 95  ? 113.157 135.226 141.325 1.00 23.16  ? 95  TRP A CD1  1 
ATOM   2730 C CD2  . TRP B 1 95  ? 113.155 135.399 139.094 1.00 21.82  ? 95  TRP A CD2  1 
ATOM   2731 N NE1  . TRP B 1 95  ? 113.286 133.961 140.806 1.00 22.51  ? 95  TRP A NE1  1 
ATOM   2732 C CE2  . TRP B 1 95  ? 113.285 134.041 139.438 1.00 24.10  ? 95  TRP A CE2  1 
ATOM   2733 C CE3  . TRP B 1 95  ? 113.126 135.753 137.741 1.00 17.75  ? 95  TRP A CE3  1 
ATOM   2734 C CZ2  . TRP B 1 95  ? 113.388 133.033 138.477 1.00 22.93  ? 95  TRP A CZ2  1 
ATOM   2735 C CZ3  . TRP B 1 95  ? 113.229 134.754 136.792 1.00 15.79  ? 95  TRP A CZ3  1 
ATOM   2736 C CH2  . TRP B 1 95  ? 113.358 133.410 137.163 1.00 18.56  ? 95  TRP A CH2  1 
ATOM   2737 N N    . ASP B 1 96  ? 114.803 140.739 140.045 1.00 17.27  ? 96  ASP A N    1 
ATOM   2738 C CA   . ASP B 1 96  ? 114.678 142.133 139.655 1.00 16.53  ? 96  ASP A CA   1 
ATOM   2739 C C    . ASP B 1 96  ? 114.896 142.239 138.147 1.00 31.80  ? 96  ASP A C    1 
ATOM   2740 O O    . ASP B 1 96  ? 115.177 141.247 137.468 1.00 30.86  ? 96  ASP A O    1 
ATOM   2741 C CB   . ASP B 1 96  ? 115.666 143.004 140.433 1.00 22.24  ? 96  ASP A CB   1 
ATOM   2742 C CG   . ASP B 1 96  ? 117.103 142.778 140.008 1.00 39.99  ? 96  ASP A CG   1 
ATOM   2743 O OD1  . ASP B 1 96  ? 117.516 141.606 139.881 1.00 42.62  ? 96  ASP A OD1  1 
ATOM   2744 O OD2  . ASP B 1 96  ? 117.823 143.779 139.808 1.00 43.45  ? 96  ASP A OD2  1 
ATOM   2745 N N    . PHE B 1 97  ? 114.753 143.451 137.607 1.00 29.62  ? 97  PHE A N    1 
ATOM   2746 C CA   . PHE B 1 97  ? 114.800 143.609 136.156 1.00 22.96  ? 97  PHE A CA   1 
ATOM   2747 C C    . PHE B 1 97  ? 116.147 143.174 135.586 1.00 26.86  ? 97  PHE A C    1 
ATOM   2748 O O    . PHE B 1 97  ? 116.203 142.490 134.554 1.00 32.00  ? 97  PHE A O    1 
ATOM   2749 C CB   . PHE B 1 97  ? 114.494 145.052 135.762 1.00 22.43  ? 97  PHE A CB   1 
ATOM   2750 C CG   . PHE B 1 97  ? 114.309 145.238 134.286 1.00 27.10  ? 97  PHE A CG   1 
ATOM   2751 C CD1  . PHE B 1 97  ? 113.084 144.990 133.695 1.00 24.71  ? 97  PHE A CD1  1 
ATOM   2752 C CD2  . PHE B 1 97  ? 115.366 145.643 133.485 1.00 27.69  ? 97  PHE A CD2  1 
ATOM   2753 C CE1  . PHE B 1 97  ? 112.912 145.146 132.336 1.00 25.24  ? 97  PHE A CE1  1 
ATOM   2754 C CE2  . PHE B 1 97  ? 115.200 145.800 132.125 1.00 25.11  ? 97  PHE A CE2  1 
ATOM   2755 C CZ   . PHE B 1 97  ? 113.972 145.553 131.550 1.00 26.72  ? 97  PHE A CZ   1 
ATOM   2756 N N    . THR B 1 98  ? 117.242 143.556 136.246 1.00 23.56  ? 98  THR A N    1 
ATOM   2757 C CA   . THR B 1 98  ? 118.568 143.161 135.776 1.00 29.91  ? 98  THR A CA   1 
ATOM   2758 C C    . THR B 1 98  ? 118.802 141.664 135.951 1.00 30.62  ? 98  THR A C    1 
ATOM   2759 O O    . THR B 1 98  ? 119.378 141.015 135.069 1.00 36.71  ? 98  THR A O    1 
ATOM   2760 C CB   . THR B 1 98  ? 119.637 143.966 136.515 1.00 30.31  ? 98  THR A CB   1 
ATOM   2761 O OG1  . THR B 1 98  ? 119.144 145.285 136.773 1.00 24.80  ? 98  THR A OG1  1 
ATOM   2762 C CG2  . THR B 1 98  ? 120.890 144.075 135.663 1.00 36.01  ? 98  THR A CG2  1 
ATOM   2763 N N    . GLY B 1 99  ? 118.374 141.100 137.083 1.00 18.86  ? 99  GLY A N    1 
ATOM   2764 C CA   . GLY B 1 99  ? 118.476 139.660 137.258 1.00 22.28  ? 99  GLY A CA   1 
ATOM   2765 C C    . GLY B 1 99  ? 117.633 138.888 136.260 1.00 25.33  ? 99  GLY A C    1 
ATOM   2766 O O    . GLY B 1 99  ? 118.056 137.848 135.751 1.00 26.33  ? 99  GLY A O    1 
ATOM   2767 N N    . ALA B 1 100 ? 116.434 139.392 135.960 1.00 23.83  ? 100 ALA A N    1 
ATOM   2768 C CA   . ALA B 1 100 ? 115.602 138.758 134.943 1.00 21.71  ? 100 ALA A CA   1 
ATOM   2769 C C    . ALA B 1 100 ? 116.253 138.847 133.566 1.00 22.90  ? 100 ALA A C    1 
ATOM   2770 O O    . ALA B 1 100 ? 116.161 137.909 132.765 1.00 24.60  ? 100 ALA A O    1 
ATOM   2771 C CB   . ALA B 1 100 ? 114.214 139.398 134.932 1.00 22.97  ? 100 ALA A CB   1 
ATOM   2772 N N    . PHE B 1 101 ? 116.900 139.978 133.270 1.00 15.16  ? 101 PHE A N    1 
ATOM   2773 C CA   . PHE B 1 101 ? 117.625 140.112 132.010 1.00 19.69  ? 101 PHE A CA   1 
ATOM   2774 C C    . PHE B 1 101 ? 118.762 139.103 131.915 1.00 21.56  ? 101 PHE A C    1 
ATOM   2775 O O    . PHE B 1 101 ? 118.949 138.456 130.877 1.00 29.57  ? 101 PHE A O    1 
ATOM   2776 C CB   . PHE B 1 101 ? 118.156 141.543 131.875 1.00 18.31  ? 101 PHE A CB   1 
ATOM   2777 C CG   . PHE B 1 101 ? 118.647 141.880 130.499 1.00 25.93  ? 101 PHE A CG   1 
ATOM   2778 C CD1  . PHE B 1 101 ? 117.762 142.253 129.504 1.00 19.98  ? 101 PHE A CD1  1 
ATOM   2779 C CD2  . PHE B 1 101 ? 120.000 141.840 130.203 1.00 23.21  ? 101 PHE A CD2  1 
ATOM   2780 C CE1  . PHE B 1 101 ? 118.212 142.565 128.238 1.00 23.76  ? 101 PHE A CE1  1 
ATOM   2781 C CE2  . PHE B 1 101 ? 120.456 142.152 128.940 1.00 20.95  ? 101 PHE A CE2  1 
ATOM   2782 C CZ   . PHE B 1 101 ? 119.561 142.516 127.956 1.00 27.16  ? 101 PHE A CZ   1 
ATOM   2783 N N    . TYR B 1 102 ? 119.524 138.948 133.002 1.00 12.90  ? 102 TYR A N    1 
ATOM   2784 C CA   . TYR B 1 102 ? 120.575 137.934 133.040 1.00 16.08  ? 102 TYR A CA   1 
ATOM   2785 C C    . TYR B 1 102 ? 119.997 136.538 132.826 1.00 25.20  ? 102 TYR A C    1 
ATOM   2786 O O    . TYR B 1 102 ? 120.561 135.728 132.077 1.00 23.87  ? 102 TYR A O    1 
ATOM   2787 C CB   . TYR B 1 102 ? 121.320 138.019 134.375 1.00 19.98  ? 102 TYR A CB   1 
ATOM   2788 C CG   . TYR B 1 102 ? 122.746 137.510 134.355 1.00 25.77  ? 102 TYR A CG   1 
ATOM   2789 C CD1  . TYR B 1 102 ? 123.185 136.631 133.374 1.00 26.58  ? 102 TYR A CD1  1 
ATOM   2790 C CD2  . TYR B 1 102 ? 123.654 137.909 135.326 1.00 21.63  ? 102 TYR A CD2  1 
ATOM   2791 C CE1  . TYR B 1 102 ? 124.486 136.166 133.358 1.00 27.67  ? 102 TYR A CE1  1 
ATOM   2792 C CE2  . TYR B 1 102 ? 124.956 137.450 135.320 1.00 23.54  ? 102 TYR A CE2  1 
ATOM   2793 C CZ   . TYR B 1 102 ? 125.367 136.580 134.333 1.00 26.45  ? 102 TYR A CZ   1 
ATOM   2794 O OH   . TYR B 1 102 ? 126.661 136.120 134.324 1.00 32.33  ? 102 TYR A OH   1 
ATOM   2795 N N    . PHE B 1 103 ? 118.870 136.240 133.478 1.00 23.13  ? 103 PHE A N    1 
ATOM   2796 C CA   . PHE B 1 103 ? 118.248 134.925 133.356 1.00 17.33  ? 103 PHE A CA   1 
ATOM   2797 C C    . PHE B 1 103 ? 117.833 134.640 131.918 1.00 17.07  ? 103 PHE A C    1 
ATOM   2798 O O    . PHE B 1 103 ? 118.128 133.570 131.374 1.00 23.34  ? 103 PHE A O    1 
ATOM   2799 C CB   . PHE B 1 103 ? 117.047 134.835 134.300 1.00 16.69  ? 103 PHE A CB   1 
ATOM   2800 C CG   . PHE B 1 103 ? 116.181 133.627 134.072 1.00 25.34  ? 103 PHE A CG   1 
ATOM   2801 C CD1  . PHE B 1 103 ? 116.615 132.364 134.442 1.00 21.65  ? 103 PHE A CD1  1 
ATOM   2802 C CD2  . PHE B 1 103 ? 114.931 133.757 133.486 1.00 24.43  ? 103 PHE A CD2  1 
ATOM   2803 C CE1  . PHE B 1 103 ? 115.816 131.255 134.234 1.00 22.09  ? 103 PHE A CE1  1 
ATOM   2804 C CE2  . PHE B 1 103 ? 114.133 132.652 133.274 1.00 22.37  ? 103 PHE A CE2  1 
ATOM   2805 C CZ   . PHE B 1 103 ? 114.575 131.400 133.649 1.00 21.13  ? 103 PHE A CZ   1 
ATOM   2806 N N    . VAL B 1 104 ? 117.137 135.586 131.284 1.00 19.40  ? 104 VAL A N    1 
ATOM   2807 C CA   . VAL B 1 104 ? 116.677 135.343 129.921 1.00 21.17  ? 104 VAL A CA   1 
ATOM   2808 C C    . VAL B 1 104 ? 117.863 135.256 128.967 1.00 19.19  ? 104 VAL A C    1 
ATOM   2809 O O    . VAL B 1 104 ? 117.826 134.491 127.991 1.00 20.03  ? 104 VAL A O    1 
ATOM   2810 C CB   . VAL B 1 104 ? 115.651 136.408 129.475 1.00 17.52  ? 104 VAL A CB   1 
ATOM   2811 C CG1  . VAL B 1 104 ? 114.420 136.366 130.367 1.00 14.26  ? 104 VAL A CG1  1 
ATOM   2812 C CG2  . VAL B 1 104 ? 116.262 137.795 129.454 1.00 12.86  ? 104 VAL A CG2  1 
ATOM   2813 N N    . GLY B 1 105 ? 118.926 136.025 129.221 1.00 28.03  ? 105 GLY A N    1 
ATOM   2814 C CA   . GLY B 1 105 ? 120.129 135.893 128.414 1.00 15.22  ? 105 GLY A CA   1 
ATOM   2815 C C    . GLY B 1 105 ? 120.760 134.517 128.519 1.00 17.24  ? 105 GLY A C    1 
ATOM   2816 O O    . GLY B 1 105 ? 121.200 133.949 127.518 1.00 22.03  ? 105 GLY A O    1 
ATOM   2817 N N    . THR B 1 106 ? 120.819 133.964 129.734 1.00 28.16  ? 106 THR A N    1 
ATOM   2818 C CA   . THR B 1 106 ? 121.329 132.604 129.891 1.00 24.36  ? 106 THR A CA   1 
ATOM   2819 C C    . THR B 1 106 ? 120.386 131.563 129.297 1.00 22.42  ? 106 THR A C    1 
ATOM   2820 O O    . THR B 1 106 ? 120.833 130.466 128.947 1.00 27.82  ? 106 THR A O    1 
ATOM   2821 C CB   . THR B 1 106 ? 121.580 132.276 131.366 1.00 23.83  ? 106 THR A CB   1 
ATOM   2822 O OG1  . THR B 1 106 ? 120.348 132.350 132.094 1.00 25.67  ? 106 THR A OG1  1 
ATOM   2823 C CG2  . THR B 1 106 ? 122.588 133.241 131.966 1.00 20.89  ? 106 THR A CG2  1 
ATOM   2824 N N    . VAL B 1 107 ? 119.099 131.883 129.179 1.00 23.83  ? 107 VAL A N    1 
ATOM   2825 C CA   . VAL B 1 107 ? 118.133 130.919 128.657 1.00 17.34  ? 107 VAL A CA   1 
ATOM   2826 C C    . VAL B 1 107 ? 118.211 130.845 127.137 1.00 17.80  ? 107 VAL A C    1 
ATOM   2827 O O    . VAL B 1 107 ? 118.321 129.758 126.559 1.00 22.55  ? 107 VAL A O    1 
ATOM   2828 C CB   . VAL B 1 107 ? 116.711 131.264 129.136 1.00 17.32  ? 107 VAL A CB   1 
ATOM   2829 C CG1  . VAL B 1 107 ? 115.677 130.549 128.283 1.00 17.46  ? 107 VAL A CG1  1 
ATOM   2830 C CG2  . VAL B 1 107 ? 116.540 130.885 130.595 1.00 15.72  ? 107 VAL A CG2  1 
ATOM   2831 N N    . VAL B 1 108 ? 118.156 131.999 126.466 1.00 26.31  ? 108 VAL A N    1 
ATOM   2832 C CA   . VAL B 1 108 ? 118.078 132.010 125.006 1.00 20.23  ? 108 VAL A CA   1 
ATOM   2833 C C    . VAL B 1 108 ? 119.356 131.470 124.372 1.00 25.00  ? 108 VAL A C    1 
ATOM   2834 O O    . VAL B 1 108 ? 119.327 130.947 123.252 1.00 31.02  ? 108 VAL A O    1 
ATOM   2835 C CB   . VAL B 1 108 ? 117.754 133.424 124.488 1.00 14.78  ? 108 VAL A CB   1 
ATOM   2836 C CG1  . VAL B 1 108 ? 116.387 133.875 124.980 1.00 17.72  ? 108 VAL A CG1  1 
ATOM   2837 C CG2  . VAL B 1 108 ? 118.839 134.412 124.893 1.00 15.97  ? 108 VAL A CG2  1 
ATOM   2838 N N    . SER B 1 109 ? 120.490 131.586 125.058 1.00 28.81  ? 109 SER A N    1 
ATOM   2839 C CA   . SER B 1 109 ? 121.760 131.076 124.555 1.00 18.16  ? 109 SER A CA   1 
ATOM   2840 C C    . SER B 1 109 ? 121.998 129.608 124.889 1.00 25.70  ? 109 SER A C    1 
ATOM   2841 O O    . SER B 1 109 ? 123.041 129.066 124.512 1.00 27.97  ? 109 SER A O    1 
ATOM   2842 C CB   . SER B 1 109 ? 122.914 131.916 125.106 1.00 18.92  ? 109 SER A CB   1 
ATOM   2843 O OG   . SER B 1 109 ? 122.888 131.938 126.522 1.00 18.20  ? 109 SER A OG   1 
ATOM   2844 N N    . THR B 1 110 ? 121.048 128.952 125.561 1.00 26.54  ? 110 THR A N    1 
ATOM   2845 C CA   . THR B 1 110 ? 121.161 127.548 125.986 1.00 21.32  ? 110 THR A CA   1 
ATOM   2846 C C    . THR B 1 110 ? 122.421 127.303 126.814 1.00 19.70  ? 110 THR A C    1 
ATOM   2847 O O    . THR B 1 110 ? 123.044 126.243 126.735 1.00 33.56  ? 110 THR A O    1 
ATOM   2848 C CB   . THR B 1 110 ? 121.099 126.576 124.798 1.00 27.34  ? 110 THR A CB   1 
ATOM   2849 O OG1  . THR B 1 110 ? 121.771 127.123 123.656 1.00 35.57  ? 110 THR A OG1  1 
ATOM   2850 C CG2  . THR B 1 110 ? 119.656 126.270 124.430 1.00 24.15  ? 110 THR A CG2  1 
ATOM   2851 N N    . ILE B 1 111 ? 122.787 128.286 127.633 1.00 8.99   ? 111 ILE A N    1 
ATOM   2852 C CA   . ILE B 1 111 ? 123.883 128.104 128.583 1.00 17.84  ? 111 ILE A CA   1 
ATOM   2853 C C    . ILE B 1 111 ? 123.378 127.403 129.834 1.00 30.87  ? 111 ILE A C    1 
ATOM   2854 O O    . ILE B 1 111 ? 123.909 126.365 130.249 1.00 38.94  ? 111 ILE A O    1 
ATOM   2855 C CB   . ILE B 1 111 ? 124.548 129.454 128.910 1.00 23.80  ? 111 ILE A CB   1 
ATOM   2856 C CG1  . ILE B 1 111 ? 125.259 130.004 127.670 1.00 26.55  ? 111 ILE A CG1  1 
ATOM   2857 C CG2  . ILE B 1 111 ? 125.525 129.306 130.063 1.00 12.47  ? 111 ILE A CG2  1 
ATOM   2858 C CD1  . ILE B 1 111 ? 125.964 131.318 127.900 1.00 22.21  ? 111 ILE A CD1  1 
ATOM   2859 N N    . GLY B 1 112 ? 122.349 127.967 130.459 1.00 18.48  ? 112 GLY A N    1 
ATOM   2860 C CA   . GLY B 1 112 ? 121.693 127.363 131.600 1.00 12.18  ? 112 GLY A CA   1 
ATOM   2861 C C    . GLY B 1 112 ? 122.477 127.205 132.884 1.00 19.34  ? 112 GLY A C    1 
ATOM   2862 O O    . GLY B 1 112 ? 122.470 126.118 133.471 1.00 31.85  ? 112 GLY A O    1 
ATOM   2863 N N    . PHE B 1 113 ? 123.176 128.265 133.311 1.00 24.99  ? 113 PHE A N    1 
ATOM   2864 C CA   . PHE B 1 113 ? 124.026 128.196 134.500 1.00 17.66  ? 113 PHE A CA   1 
ATOM   2865 C C    . PHE B 1 113 ? 123.319 127.505 135.661 1.00 25.90  ? 113 PHE A C    1 
ATOM   2866 O O    . PHE B 1 113 ? 123.936 126.728 136.398 1.00 36.00  ? 113 PHE A O    1 
ATOM   2867 C CB   . PHE B 1 113 ? 124.479 129.599 134.911 1.00 14.56  ? 113 PHE A CB   1 
ATOM   2868 C CG   . PHE B 1 113 ? 125.627 130.132 134.101 1.00 27.90  ? 113 PHE A CG   1 
ATOM   2869 C CD1  . PHE B 1 113 ? 126.702 129.318 133.784 1.00 34.31  ? 113 PHE A CD1  1 
ATOM   2870 C CD2  . PHE B 1 113 ? 125.638 131.447 133.668 1.00 28.00  ? 113 PHE A CD2  1 
ATOM   2871 C CE1  . PHE B 1 113 ? 127.764 129.804 133.046 1.00 30.92  ? 113 PHE A CE1  1 
ATOM   2872 C CE2  . PHE B 1 113 ? 126.697 131.940 132.930 1.00 24.94  ? 113 PHE A CE2  1 
ATOM   2873 C CZ   . PHE B 1 113 ? 127.762 131.116 132.618 1.00 25.26  ? 113 PHE A CZ   1 
ATOM   2874 N N    . GLY B 1 114 ? 122.029 127.787 135.848 1.00 19.41  ? 114 GLY A N    1 
ATOM   2875 C CA   . GLY B 1 114 ? 121.268 127.236 136.946 1.00 21.41  ? 114 GLY A CA   1 
ATOM   2876 C C    . GLY B 1 114 ? 121.254 128.057 138.217 1.00 27.86  ? 114 GLY A C    1 
ATOM   2877 O O    . GLY B 1 114 ? 120.616 127.642 139.193 1.00 33.54  ? 114 GLY A O    1 
ATOM   2878 N N    . MET B 1 115 ? 121.946 129.196 138.247 1.00 29.07  ? 115 MET A N    1 
ATOM   2879 C CA   . MET B 1 115 ? 121.905 130.062 139.420 1.00 24.99  ? 115 MET A CA   1 
ATOM   2880 C C    . MET B 1 115 ? 120.517 130.648 139.662 1.00 30.32  ? 115 MET A C    1 
ATOM   2881 O O    . MET B 1 115 ? 120.224 131.069 140.785 1.00 34.70  ? 115 MET A O    1 
ATOM   2882 C CB   . MET B 1 115 ? 122.937 131.182 139.286 1.00 22.90  ? 115 MET A CB   1 
ATOM   2883 C CG   . MET B 1 115 ? 122.474 132.382 138.478 1.00 31.45  ? 115 MET A CG   1 
ATOM   2884 S SD   . MET B 1 115 ? 122.669 132.151 136.703 1.00 47.03  ? 115 MET A SD   1 
ATOM   2885 C CE   . MET B 1 115 ? 122.190 133.767 136.098 1.00 19.15  ? 115 MET A CE   1 
ATOM   2886 N N    . THR B 1 116 ? 119.661 130.685 138.642 1.00 28.47  ? 116 THR A N    1 
ATOM   2887 C CA   . THR B 1 116 ? 118.315 131.239 138.764 1.00 23.39  ? 116 THR A CA   1 
ATOM   2888 C C    . THR B 1 116 ? 117.363 130.383 137.945 1.00 29.97  ? 116 THR A C    1 
ATOM   2889 O O    . THR B 1 116 ? 117.535 130.249 136.731 1.00 33.59  ? 116 THR A O    1 
ATOM   2890 C CB   . THR B 1 116 ? 118.274 132.697 138.291 1.00 19.22  ? 116 THR A CB   1 
ATOM   2891 O OG1  . THR B 1 116 ? 119.176 133.485 139.079 1.00 33.41  ? 116 THR A OG1  1 
ATOM   2892 C CG2  . THR B 1 116 ? 116.873 133.264 138.430 1.00 14.93  ? 116 THR A CG2  1 
ATOM   2893 N N    . THR B 1 117 ? 116.372 129.788 138.608 1.00 31.45  ? 117 THR A N    1 
ATOM   2894 C CA   . THR B 1 117 ? 115.418 128.900 137.960 1.00 24.92  ? 117 THR A CA   1 
ATOM   2895 C C    . THR B 1 117 ? 113.995 129.248 138.372 1.00 29.47  ? 117 THR A C    1 
ATOM   2896 O O    . THR B 1 117 ? 113.766 129.731 139.485 1.00 30.23  ? 117 THR A O    1 
ATOM   2897 C CB   . THR B 1 117 ? 115.701 127.431 138.310 1.00 25.60  ? 117 THR A CB   1 
ATOM   2898 O OG1  . THR B 1 117 ? 116.008 127.318 139.705 1.00 41.90  ? 117 THR A OG1  1 
ATOM   2899 C CG2  . THR B 1 117 ? 116.872 126.907 137.499 1.00 23.03  ? 117 THR A CG2  1 
ATOM   2900 N N    . PRO B 1 118 ? 113.021 129.019 137.488 1.00 30.29  ? 118 PRO A N    1 
ATOM   2901 C CA   . PRO B 1 118 ? 111.615 129.240 137.863 1.00 24.57  ? 118 PRO A CA   1 
ATOM   2902 C C    . PRO B 1 118 ? 111.174 128.296 138.970 1.00 26.51  ? 118 PRO A C    1 
ATOM   2903 O O    . PRO B 1 118 ? 111.584 127.135 139.027 1.00 33.26  ? 118 PRO A O    1 
ATOM   2904 C CB   . PRO B 1 118 ? 110.855 128.973 136.558 1.00 22.64  ? 118 PRO A CB   1 
ATOM   2905 C CG   . PRO B 1 118 ? 111.876 129.100 135.476 1.00 28.16  ? 118 PRO A CG   1 
ATOM   2906 C CD   . PRO B 1 118 ? 113.161 128.630 136.075 1.00 29.90  ? 118 PRO A CD   1 
ATOM   2907 N N    . ALA B 1 119 ? 110.312 128.803 139.855 1.00 23.73  ? 119 ALA A N    1 
ATOM   2908 C CA   . ALA B 1 119 ? 109.834 128.033 140.991 1.00 26.59  ? 119 ALA A CA   1 
ATOM   2909 C C    . ALA B 1 119 ? 108.317 127.957 141.110 1.00 31.74  ? 119 ALA A C    1 
ATOM   2910 O O    . ALA B 1 119 ? 107.824 127.277 142.016 1.00 38.41  ? 119 ALA A O    1 
ATOM   2911 C CB   . ALA B 1 119 ? 110.404 128.603 142.300 1.00 29.52  ? 119 ALA A CB   1 
ATOM   2912 N N    . THR B 1 120 ? 107.565 128.616 140.235 1.00 29.26  ? 120 THR A N    1 
ATOM   2913 C CA   . THR B 1 120 ? 106.112 128.638 140.326 1.00 27.41  ? 120 THR A CA   1 
ATOM   2914 C C    . THR B 1 120 ? 105.492 128.033 139.075 1.00 34.18  ? 120 THR A C    1 
ATOM   2915 O O    . THR B 1 120 ? 106.080 128.063 137.989 1.00 37.33  ? 120 THR A O    1 
ATOM   2916 C CB   . THR B 1 120 ? 105.580 130.068 140.515 1.00 28.31  ? 120 THR A CB   1 
ATOM   2917 O OG1  . THR B 1 120 ? 105.684 130.791 139.282 1.00 24.42  ? 120 THR A OG1  1 
ATOM   2918 C CG2  . THR B 1 120 ? 106.366 130.799 141.591 1.00 27.24  ? 120 THR A CG2  1 
ATOM   2919 N N    . VAL B 1 121 ? 104.296 127.469 139.245 1.00 35.54  ? 121 VAL A N    1 
ATOM   2920 C CA   . VAL B 1 121 ? 103.491 127.051 138.106 1.00 28.23  ? 121 VAL A CA   1 
ATOM   2921 C C    . VAL B 1 121 ? 102.993 128.288 137.371 1.00 37.25  ? 121 VAL A C    1 
ATOM   2922 O O    . VAL B 1 121 ? 102.377 129.181 137.968 1.00 40.76  ? 121 VAL A O    1 
ATOM   2923 C CB   . VAL B 1 121 ? 102.323 126.162 138.563 1.00 30.47  ? 121 VAL A CB   1 
ATOM   2924 C CG1  . VAL B 1 121 ? 101.286 126.034 137.459 1.00 29.56  ? 121 VAL A CG1  1 
ATOM   2925 C CG2  . VAL B 1 121 ? 102.828 124.795 138.982 1.00 35.84  ? 121 VAL A CG2  1 
ATOM   2926 N N    . GLY B 1 122 ? 103.258 128.345 136.071 1.00 27.83  ? 122 GLY A N    1 
ATOM   2927 C CA   . GLY B 1 122 ? 102.991 129.537 135.293 1.00 23.02  ? 122 GLY A CA   1 
ATOM   2928 C C    . GLY B 1 122 ? 104.273 130.131 134.749 1.00 29.87  ? 122 GLY A C    1 
ATOM   2929 O O    . GLY B 1 122 ? 104.330 130.547 133.588 1.00 40.21  ? 122 GLY A O    1 
ATOM   2930 N N    . GLY B 1 123 ? 105.313 130.166 135.581 1.00 22.51  ? 123 GLY A N    1 
ATOM   2931 C CA   . GLY B 1 123 ? 106.638 130.496 135.100 1.00 21.40  ? 123 GLY A CA   1 
ATOM   2932 C C    . GLY B 1 123 ? 107.360 129.367 134.402 1.00 24.80  ? 123 GLY A C    1 
ATOM   2933 O O    . GLY B 1 123 ? 108.279 129.627 133.619 1.00 30.26  ? 123 GLY A O    1 
ATOM   2934 N N    . LYS B 1 124 ? 106.873 128.134 134.548 1.00 27.57  ? 124 LYS A N    1 
ATOM   2935 C CA   . LYS B 1 124 ? 107.460 127.006 133.839 1.00 23.86  ? 124 LYS A CA   1 
ATOM   2936 C C    . LYS B 1 124 ? 106.780 126.762 132.503 1.00 28.65  ? 124 LYS A C    1 
ATOM   2937 O O    . LYS B 1 124 ? 107.456 126.416 131.528 1.00 30.37  ? 124 LYS A O    1 
ATOM   2938 C CB   . LYS B 1 124 ? 107.375 125.743 134.703 1.00 24.25  ? 124 LYS A CB   1 
ATOM   2939 C CG   . LYS B 1 124 ? 108.151 125.837 136.002 1.00 20.79  ? 124 LYS A CG   1 
ATOM   2940 C CD   . LYS B 1 124 ? 108.101 124.536 136.779 1.00 19.98  ? 124 LYS A CD   1 
ATOM   2941 C CE   . LYS B 1 124 ? 108.962 124.616 138.025 1.00 21.95  ? 124 LYS A CE   1 
ATOM   2942 N NZ   . LYS B 1 124 ? 108.893 123.376 138.840 1.00 25.92  ? 124 LYS A NZ   1 
ATOM   2943 N N    . ILE B 1 125 ? 105.477 127.018 132.410 1.00 25.61  ? 125 ILE A N    1 
ATOM   2944 C CA   . ILE B 1 125 ? 104.826 126.973 131.107 1.00 25.74  ? 125 ILE A CA   1 
ATOM   2945 C C    . ILE B 1 125 ? 105.369 128.105 130.247 1.00 29.88  ? 125 ILE A C    1 
ATOM   2946 O O    . ILE B 1 125 ? 105.704 127.917 129.067 1.00 32.99  ? 125 ILE A O    1 
ATOM   2947 C CB   . ILE B 1 125 ? 103.298 127.060 131.265 1.00 20.37  ? 125 ILE A CB   1 
ATOM   2948 C CG1  . ILE B 1 125 ? 102.825 126.161 132.406 1.00 19.41  ? 125 ILE A CG1  1 
ATOM   2949 C CG2  . ILE B 1 125 ? 102.605 126.680 129.971 1.00 28.78  ? 125 ILE A CG2  1 
ATOM   2950 C CD1  . ILE B 1 125 ? 101.356 126.315 132.725 1.00 22.09  ? 125 ILE A CD1  1 
ATOM   2951 N N    . PHE B 1 126 ? 105.430 129.311 130.823 1.00 25.21  ? 126 PHE A N    1 
ATOM   2952 C CA   . PHE B 1 126 ? 106.005 130.439 130.107 1.00 21.09  ? 126 PHE A CA   1 
ATOM   2953 C C    . PHE B 1 126 ? 107.472 130.190 129.785 1.00 19.21  ? 126 PHE A C    1 
ATOM   2954 O O    . PHE B 1 126 ? 107.943 130.606 128.725 1.00 28.26  ? 126 PHE A O    1 
ATOM   2955 C CB   . PHE B 1 126 ? 105.846 131.720 130.930 1.00 21.01  ? 126 PHE A CB   1 
ATOM   2956 C CG   . PHE B 1 126 ? 106.264 132.962 130.198 1.00 27.82  ? 126 PHE A CG   1 
ATOM   2957 C CD1  . PHE B 1 126 ? 105.534 133.425 129.116 1.00 25.73  ? 126 PHE A CD1  1 
ATOM   2958 C CD2  . PHE B 1 126 ? 107.386 133.668 130.596 1.00 26.14  ? 126 PHE A CD2  1 
ATOM   2959 C CE1  . PHE B 1 126 ? 105.920 134.566 128.443 1.00 22.60  ? 126 PHE A CE1  1 
ATOM   2960 C CE2  . PHE B 1 126 ? 107.775 134.808 129.926 1.00 19.92  ? 126 PHE A CE2  1 
ATOM   2961 C CZ   . PHE B 1 126 ? 107.042 135.260 128.848 1.00 25.75  ? 126 PHE A CZ   1 
ATOM   2962 N N    . LEU B 1 127 ? 108.206 129.502 130.671 1.00 15.57  ? 127 LEU A N    1 
ATOM   2963 C CA   . LEU B 1 127 ? 109.585 129.143 130.358 1.00 22.29  ? 127 LEU A CA   1 
ATOM   2964 C C    . LEU B 1 127 ? 109.654 128.248 129.126 1.00 24.92  ? 127 LEU A C    1 
ATOM   2965 O O    . LEU B 1 127 ? 110.483 128.464 128.233 1.00 28.28  ? 127 LEU A O    1 
ATOM   2966 C CB   . LEU B 1 127 ? 110.227 128.457 131.566 1.00 23.88  ? 127 LEU A CB   1 
ATOM   2967 C CG   . LEU B 1 127 ? 111.736 128.173 131.563 1.00 22.78  ? 127 LEU A CG   1 
ATOM   2968 C CD1  . LEU B 1 127 ? 112.053 126.800 130.986 1.00 18.56  ? 127 LEU A CD1  1 
ATOM   2969 C CD2  . LEU B 1 127 ? 112.501 129.257 130.821 1.00 23.13  ? 127 LEU A CD2  1 
ATOM   2970 N N    . ILE B 1 128 ? 108.761 127.258 129.048 1.00 25.51  ? 128 ILE A N    1 
ATOM   2971 C CA   . ILE B 1 128 ? 108.765 126.326 127.924 1.00 25.41  ? 128 ILE A CA   1 
ATOM   2972 C C    . ILE B 1 128 ? 108.480 127.066 126.623 1.00 27.40  ? 128 ILE A C    1 
ATOM   2973 O O    . ILE B 1 128 ? 109.213 126.929 125.635 1.00 28.76  ? 128 ILE A O    1 
ATOM   2974 C CB   . ILE B 1 128 ? 107.756 125.189 128.164 1.00 25.20  ? 128 ILE A CB   1 
ATOM   2975 C CG1  . ILE B 1 128 ? 108.239 124.280 129.296 1.00 23.60  ? 128 ILE A CG1  1 
ATOM   2976 C CG2  . ILE B 1 128 ? 107.535 124.387 126.892 1.00 21.67  ? 128 ILE A CG2  1 
ATOM   2977 C CD1  . ILE B 1 128 ? 107.280 123.166 129.634 1.00 18.26  ? 128 ILE A CD1  1 
ATOM   2978 N N    . PHE B 1 129 ? 107.414 127.870 126.609 1.00 26.94  ? 129 PHE A N    1 
ATOM   2979 C CA   . PHE B 1 129 ? 107.056 128.585 125.384 1.00 22.80  ? 129 PHE A CA   1 
ATOM   2980 C C    . PHE B 1 129 ? 108.121 129.611 125.000 1.00 25.86  ? 129 PHE A C    1 
ATOM   2981 O O    . PHE B 1 129 ? 108.466 129.746 123.816 1.00 28.41  ? 129 PHE A O    1 
ATOM   2982 C CB   . PHE B 1 129 ? 105.692 129.254 125.543 1.00 18.88  ? 129 PHE A CB   1 
ATOM   2983 C CG   . PHE B 1 129 ? 104.531 128.304 125.420 1.00 25.01  ? 129 PHE A CG   1 
ATOM   2984 C CD1  . PHE B 1 129 ? 104.066 127.608 126.522 1.00 27.66  ? 129 PHE A CD1  1 
ATOM   2985 C CD2  . PHE B 1 129 ? 103.912 128.101 124.198 1.00 29.39  ? 129 PHE A CD2  1 
ATOM   2986 C CE1  . PHE B 1 129 ? 103.004 126.733 126.409 1.00 31.00  ? 129 PHE A CE1  1 
ATOM   2987 C CE2  . PHE B 1 129 ? 102.850 127.228 124.080 1.00 32.84  ? 129 PHE A CE2  1 
ATOM   2988 C CZ   . PHE B 1 129 ? 102.396 126.543 125.187 1.00 33.24  ? 129 PHE A CZ   1 
ATOM   2989 N N    . TYR B 1 130 ? 108.665 130.332 125.984 1.00 21.77  ? 130 TYR A N    1 
ATOM   2990 C CA   . TYR B 1 130 ? 109.700 131.325 125.719 1.00 19.43  ? 130 TYR A CA   1 
ATOM   2991 C C    . TYR B 1 130 ? 110.926 130.681 125.088 1.00 26.09  ? 130 TYR A C    1 
ATOM   2992 O O    . TYR B 1 130 ? 111.454 131.180 124.087 1.00 26.95  ? 130 TYR A O    1 
ATOM   2993 C CB   . TYR B 1 130 ? 110.067 132.036 127.023 1.00 9.99   ? 130 TYR A CB   1 
ATOM   2994 C CG   . TYR B 1 130 ? 110.867 133.306 126.849 1.00 21.26  ? 130 TYR A CG   1 
ATOM   2995 C CD1  . TYR B 1 130 ? 110.240 134.512 126.560 1.00 21.84  ? 130 TYR A CD1  1 
ATOM   2996 C CD2  . TYR B 1 130 ? 112.248 133.303 126.982 1.00 19.42  ? 130 TYR A CD2  1 
ATOM   2997 C CE1  . TYR B 1 130 ? 110.966 135.673 126.407 1.00 15.51  ? 130 TYR A CE1  1 
ATOM   2998 C CE2  . TYR B 1 130 ? 112.982 134.458 126.829 1.00 21.08  ? 130 TYR A CE2  1 
ATOM   2999 C CZ   . TYR B 1 130 ? 112.337 135.641 126.541 1.00 19.29  ? 130 TYR A CZ   1 
ATOM   3000 O OH   . TYR B 1 130 ? 113.070 136.794 126.389 1.00 29.98  ? 130 TYR A OH   1 
ATOM   3001 N N    . GLY B 1 131 ? 111.394 129.565 125.653 1.00 21.42  ? 131 GLY A N    1 
ATOM   3002 C CA   . GLY B 1 131 ? 112.542 128.889 125.068 1.00 18.87  ? 131 GLY A CA   1 
ATOM   3003 C C    . GLY B 1 131 ? 112.251 128.345 123.684 1.00 21.64  ? 131 GLY A C    1 
ATOM   3004 O O    . GLY B 1 131 ? 113.070 128.480 122.766 1.00 27.36  ? 131 GLY A O    1 
ATOM   3005 N N    . LEU B 1 132 ? 111.056 127.764 123.506 1.00 22.76  ? 132 LEU A N    1 
ATOM   3006 C CA   . LEU B 1 132 ? 110.666 127.193 122.221 1.00 23.20  ? 132 LEU A CA   1 
ATOM   3007 C C    . LEU B 1 132 ? 110.651 128.247 121.124 1.00 22.79  ? 132 LEU A C    1 
ATOM   3008 O O    . LEU B 1 132 ? 110.956 127.949 119.964 1.00 28.48  ? 132 LEU A O    1 
ATOM   3009 C CB   . LEU B 1 132 ? 109.295 126.530 122.349 1.00 26.60  ? 132 LEU A CB   1 
ATOM   3010 C CG   . LEU B 1 132 ? 108.828 125.631 121.205 1.00 28.79  ? 132 LEU A CG   1 
ATOM   3011 C CD1  . LEU B 1 132 ? 109.636 124.347 121.165 1.00 28.90  ? 132 LEU A CD1  1 
ATOM   3012 C CD2  . LEU B 1 132 ? 107.345 125.329 121.345 1.00 27.69  ? 132 LEU A CD2  1 
ATOM   3013 N N    . VAL B 1 133 ? 110.273 129.481 121.460 1.00 30.13  ? 133 VAL A N    1 
ATOM   3014 C CA   . VAL B 1 133 ? 110.278 130.542 120.458 1.00 28.01  ? 133 VAL A CA   1 
ATOM   3015 C C    . VAL B 1 133 ? 111.630 131.247 120.346 1.00 26.36  ? 133 VAL A C    1 
ATOM   3016 O O    . VAL B 1 133 ? 111.937 131.809 119.284 1.00 23.84  ? 133 VAL A O    1 
ATOM   3017 C CB   . VAL B 1 133 ? 109.167 131.570 120.746 1.00 27.28  ? 133 VAL A CB   1 
ATOM   3018 C CG1  . VAL B 1 133 ? 109.033 132.568 119.602 1.00 18.55  ? 133 VAL A CG1  1 
ATOM   3019 C CG2  . VAL B 1 133 ? 107.839 130.868 120.965 1.00 23.85  ? 133 VAL A CG2  1 
ATOM   3020 N N    . GLY B 1 134 ? 112.471 131.186 121.377 1.00 26.12  ? 134 GLY A N    1 
ATOM   3021 C CA   . GLY B 1 134 ? 113.670 132.000 121.400 1.00 16.71  ? 134 GLY A CA   1 
ATOM   3022 C C    . GLY B 1 134 ? 114.994 131.354 121.037 1.00 22.47  ? 134 GLY A C    1 
ATOM   3023 O O    . GLY B 1 134 ? 115.884 132.040 120.530 1.00 26.89  ? 134 GLY A O    1 
ATOM   3024 N N    . CYS B 1 135 ? 115.154 130.054 121.291 1.00 22.14  ? 135 CYS A N    1 
ATOM   3025 C CA   . CYS B 1 135 ? 116.413 129.397 120.933 1.00 17.69  ? 135 CYS A CA   1 
ATOM   3026 C C    . CYS B 1 135 ? 116.696 129.363 119.431 1.00 25.67  ? 135 CYS A C    1 
ATOM   3027 O O    . CYS B 1 135 ? 117.837 129.668 119.032 1.00 34.64  ? 135 CYS A O    1 
ATOM   3028 C CB   . CYS B 1 135 ? 116.439 127.988 121.538 1.00 27.87  ? 135 CYS A CB   1 
ATOM   3029 S SG   . CYS B 1 135 ? 116.375 127.953 123.345 1.00 32.82  ? 135 CYS A SG   1 
ATOM   3030 N N    . PRO B 1 136 ? 115.743 129.017 118.553 1.00 23.64  ? 136 PRO A N    1 
ATOM   3031 C CA   . PRO B 1 136 ? 116.036 129.073 117.108 1.00 15.58  ? 136 PRO A CA   1 
ATOM   3032 C C    . PRO B 1 136 ? 116.454 130.447 116.608 1.00 21.62  ? 136 PRO A C    1 
ATOM   3033 O O    . PRO B 1 136 ? 117.278 130.528 115.686 1.00 31.89  ? 136 PRO A O    1 
ATOM   3034 C CB   . PRO B 1 136 ? 114.715 128.621 116.471 1.00 22.63  ? 136 PRO A CB   1 
ATOM   3035 C CG   . PRO B 1 136 ? 114.070 127.782 117.510 1.00 20.36  ? 136 PRO A CG   1 
ATOM   3036 C CD   . PRO B 1 136 ? 114.416 128.425 118.812 1.00 17.05  ? 136 PRO A CD   1 
ATOM   3037 N N    . SER B 1 137 ? 115.923 131.527 117.183 1.00 13.63  ? 137 SER A N    1 
ATOM   3038 C CA   . SER B 1 137 ? 116.343 132.862 116.762 1.00 12.50  ? 137 SER A CA   1 
ATOM   3039 C C    . SER B 1 137 ? 117.822 133.092 117.052 1.00 20.16  ? 137 SER A C    1 
ATOM   3040 O O    . SER B 1 137 ? 118.545 133.656 116.222 1.00 37.09  ? 137 SER A O    1 
ATOM   3041 C CB   . SER B 1 137 ? 115.481 133.920 117.450 1.00 22.10  ? 137 SER A CB   1 
ATOM   3042 O OG   . SER B 1 137 ? 114.104 133.634 117.296 1.00 31.04  ? 137 SER A OG   1 
ATOM   3043 N N    . THR B 1 138 ? 118.292 132.654 118.220 1.00 17.93  ? 138 THR A N    1 
ATOM   3044 C CA   . THR B 1 138 ? 119.703 132.811 118.556 1.00 22.16  ? 138 THR A CA   1 
ATOM   3045 C C    . THR B 1 138 ? 120.584 131.929 117.680 1.00 22.66  ? 138 THR A C    1 
ATOM   3046 O O    . THR B 1 138 ? 121.685 132.337 117.281 1.00 30.08  ? 138 THR A O    1 
ATOM   3047 C CB   . THR B 1 138 ? 119.921 132.499 120.035 1.00 23.23  ? 138 THR A CB   1 
ATOM   3048 O OG1  . THR B 1 138 ? 118.879 133.106 120.807 1.00 24.43  ? 138 THR A OG1  1 
ATOM   3049 C CG2  . THR B 1 138 ? 121.266 133.033 120.504 1.00 22.69  ? 138 THR A CG2  1 
ATOM   3050 N N    . ILE B 1 139 ? 120.115 130.719 117.355 1.00 17.19  ? 139 ILE A N    1 
ATOM   3051 C CA   . ILE B 1 139 ? 120.867 129.867 116.433 1.00 23.47  ? 139 ILE A CA   1 
ATOM   3052 C C    . ILE B 1 139 ? 121.004 130.544 115.070 1.00 28.31  ? 139 ILE A C    1 
ATOM   3053 O O    . ILE B 1 139 ? 122.088 130.554 114.463 1.00 33.10  ? 139 ILE A O    1 
ATOM   3054 C CB   . ILE B 1 139 ? 120.198 128.484 116.323 1.00 24.78  ? 139 ILE A CB   1 
ATOM   3055 C CG1  . ILE B 1 139 ? 120.260 127.758 117.668 1.00 23.36  ? 139 ILE A CG1  1 
ATOM   3056 C CG2  . ILE B 1 139 ? 120.866 127.648 115.246 1.00 25.89  ? 139 ILE A CG2  1 
ATOM   3057 C CD1  . ILE B 1 139 ? 119.570 126.414 117.667 1.00 22.00  ? 139 ILE A CD1  1 
ATOM   3058 N N    . LEU B 1 140 ? 119.910 131.124 114.574 1.00 17.90  ? 140 LEU A N    1 
ATOM   3059 C CA   . LEU B 1 140 ? 119.950 131.831 113.297 1.00 18.66  ? 140 LEU A CA   1 
ATOM   3060 C C    . LEU B 1 140 ? 120.885 133.033 113.360 1.00 27.94  ? 140 LEU A C    1 
ATOM   3061 O O    . LEU B 1 140 ? 121.607 133.322 112.397 1.00 35.35  ? 140 LEU A O    1 
ATOM   3062 C CB   . LEU B 1 140 ? 118.541 132.268 112.901 1.00 14.80  ? 140 LEU A CB   1 
ATOM   3063 C CG   . LEU B 1 140 ? 118.394 132.999 111.566 1.00 17.74  ? 140 LEU A CG   1 
ATOM   3064 C CD1  . LEU B 1 140 ? 118.740 132.087 110.401 1.00 17.54  ? 140 LEU A CD1  1 
ATOM   3065 C CD2  . LEU B 1 140 ? 116.990 133.559 111.416 1.00 19.72  ? 140 LEU A CD2  1 
ATOM   3066 N N    . PHE B 1 141 ? 120.881 133.749 114.488 1.00 25.67  ? 141 PHE A N    1 
ATOM   3067 C CA   . PHE B 1 141 ? 121.788 134.879 114.657 1.00 21.35  ? 141 PHE A CA   1 
ATOM   3068 C C    . PHE B 1 141 ? 123.242 134.432 114.573 1.00 27.79  ? 141 PHE A C    1 
ATOM   3069 O O    . PHE B 1 141 ? 124.067 135.090 113.930 1.00 29.57  ? 141 PHE A O    1 
ATOM   3070 C CB   . PHE B 1 141 ? 121.510 135.577 115.991 1.00 20.19  ? 141 PHE A CB   1 
ATOM   3071 C CG   . PHE B 1 141 ? 122.322 136.823 116.212 1.00 30.63  ? 141 PHE A CG   1 
ATOM   3072 C CD1  . PHE B 1 141 ? 121.957 138.017 115.611 1.00 25.06  ? 141 PHE A CD1  1 
ATOM   3073 C CD2  . PHE B 1 141 ? 123.443 136.804 117.024 1.00 30.49  ? 141 PHE A CD2  1 
ATOM   3074 C CE1  . PHE B 1 141 ? 122.697 139.165 115.812 1.00 20.35  ? 141 PHE A CE1  1 
ATOM   3075 C CE2  . PHE B 1 141 ? 124.189 137.951 117.229 1.00 26.73  ? 141 PHE A CE2  1 
ATOM   3076 C CZ   . PHE B 1 141 ? 123.815 139.132 116.620 1.00 24.20  ? 141 PHE A CZ   1 
ATOM   3077 N N    . PHE B 1 142 ? 123.572 133.308 115.216 1.00 28.66  ? 142 PHE A N    1 
ATOM   3078 C CA   . PHE B 1 142 ? 124.940 132.798 115.150 1.00 24.18  ? 142 PHE A CA   1 
ATOM   3079 C C    . PHE B 1 142 ? 125.325 132.408 113.724 1.00 31.80  ? 142 PHE A C    1 
ATOM   3080 O O    . PHE B 1 142 ? 126.446 132.687 113.274 1.00 37.73  ? 142 PHE A O    1 
ATOM   3081 C CB   . PHE B 1 142 ? 125.105 131.606 116.093 1.00 27.05  ? 142 PHE A CB   1 
ATOM   3082 C CG   . PHE B 1 142 ? 124.992 131.960 117.548 1.00 26.49  ? 142 PHE A CG   1 
ATOM   3083 C CD1  . PHE B 1 142 ? 125.183 133.263 117.978 1.00 29.14  ? 142 PHE A CD1  1 
ATOM   3084 C CD2  . PHE B 1 142 ? 124.693 130.988 118.487 1.00 27.49  ? 142 PHE A CD2  1 
ATOM   3085 C CE1  . PHE B 1 142 ? 125.080 133.589 119.316 1.00 30.27  ? 142 PHE A CE1  1 
ATOM   3086 C CE2  . PHE B 1 142 ? 124.588 131.310 119.824 1.00 27.87  ? 142 PHE A CE2  1 
ATOM   3087 C CZ   . PHE B 1 142 ? 124.781 132.611 120.239 1.00 28.72  ? 142 PHE A CZ   1 
ATOM   3088 N N    . ASN B 1 143 ? 124.407 131.766 112.995 1.00 32.31  ? 143 ASN A N    1 
ATOM   3089 C CA   . ASN B 1 143 ? 124.707 131.400 111.611 1.00 24.82  ? 143 ASN A CA   1 
ATOM   3090 C C    . ASN B 1 143 ? 124.945 132.632 110.742 1.00 30.13  ? 143 ASN A C    1 
ATOM   3091 O O    . ASN B 1 143 ? 125.884 132.665 109.929 1.00 42.48  ? 143 ASN A O    1 
ATOM   3092 C CB   . ASN B 1 143 ? 123.573 130.550 111.036 1.00 25.33  ? 143 ASN A CB   1 
ATOM   3093 C CG   . ASN B 1 143 ? 123.457 129.198 111.709 1.00 37.52  ? 143 ASN A CG   1 
ATOM   3094 O OD1  . ASN B 1 143 ? 124.420 128.695 112.284 1.00 43.89  ? 143 ASN A OD1  1 
ATOM   3095 N ND2  . ASN B 1 143 ? 122.273 128.605 111.642 1.00 36.09  ? 143 ASN A ND2  1 
ATOM   3096 N N    . LEU B 1 144 ? 124.103 133.656 110.897 1.00 26.28  ? 144 LEU A N    1 
ATOM   3097 C CA   . LEU B 1 144 ? 124.282 134.887 110.131 1.00 26.41  ? 144 LEU A CA   1 
ATOM   3098 C C    . LEU B 1 144 ? 125.596 135.574 110.488 1.00 30.50  ? 144 LEU A C    1 
ATOM   3099 O O    . LEU B 1 144 ? 126.279 136.123 109.611 1.00 38.61  ? 144 LEU A O    1 
ATOM   3100 C CB   . LEU B 1 144 ? 123.102 135.832 110.357 1.00 29.73  ? 144 LEU A CB   1 
ATOM   3101 C CG   . LEU B 1 144 ? 121.722 135.328 109.929 1.00 21.73  ? 144 LEU A CG   1 
ATOM   3102 C CD1  . LEU B 1 144 ? 120.677 136.415 110.119 1.00 21.96  ? 144 LEU A CD1  1 
ATOM   3103 C CD2  . LEU B 1 144 ? 121.746 134.851 108.487 1.00 29.05  ? 144 LEU A CD2  1 
ATOM   3104 N N    . PHE B 1 145 ? 125.964 135.558 111.773 1.00 31.59  ? 145 PHE A N    1 
ATOM   3105 C CA   . PHE B 1 145 ? 127.249 136.118 112.175 1.00 32.20  ? 145 PHE A CA   1 
ATOM   3106 C C    . PHE B 1 145 ? 128.398 135.391 111.493 1.00 32.40  ? 145 PHE A C    1 
ATOM   3107 O O    . PHE B 1 145 ? 129.357 136.023 111.035 1.00 39.20  ? 145 PHE A O    1 
ATOM   3108 C CB   . PHE B 1 145 ? 127.414 136.054 113.693 1.00 32.45  ? 145 PHE A CB   1 
ATOM   3109 C CG   . PHE B 1 145 ? 128.846 136.134 114.145 1.00 38.08  ? 145 PHE A CG   1 
ATOM   3110 C CD1  . PHE B 1 145 ? 129.497 137.354 114.200 1.00 36.94  ? 145 PHE A CD1  1 
ATOM   3111 C CD2  . PHE B 1 145 ? 129.546 134.990 114.496 1.00 34.76  ? 145 PHE A CD2  1 
ATOM   3112 C CE1  . PHE B 1 145 ? 130.814 137.435 114.608 1.00 35.15  ? 145 PHE A CE1  1 
ATOM   3113 C CE2  . PHE B 1 145 ? 130.867 135.067 114.901 1.00 32.83  ? 145 PHE A CE2  1 
ATOM   3114 C CZ   . PHE B 1 145 ? 131.499 136.291 114.957 1.00 34.73  ? 145 PHE A CZ   1 
ATOM   3115 N N    . LEU B 1 146 ? 128.334 134.058 111.444 1.00 30.70  ? 146 LEU A N    1 
ATOM   3116 C CA   . LEU B 1 146 ? 129.405 133.303 110.798 1.00 32.47  ? 146 LEU A CA   1 
ATOM   3117 C C    . LEU B 1 146 ? 129.505 133.641 109.315 1.00 36.87  ? 146 LEU A C    1 
ATOM   3118 O O    . LEU B 1 146 ? 130.613 133.802 108.779 1.00 44.41  ? 146 LEU A O    1 
ATOM   3119 C CB   . LEU B 1 146 ? 129.185 131.803 110.987 1.00 34.39  ? 146 LEU A CB   1 
ATOM   3120 C CG   . LEU B 1 146 ? 130.214 130.892 110.312 1.00 38.26  ? 146 LEU A CG   1 
ATOM   3121 C CD1  . LEU B 1 146 ? 131.625 131.217 110.763 1.00 33.54  ? 146 LEU A CD1  1 
ATOM   3122 C CD2  . LEU B 1 146 ? 129.891 129.430 110.580 1.00 36.44  ? 146 LEU A CD2  1 
ATOM   3123 N N    . GLU B 1 147 ? 128.362 133.750 108.634 1.00 40.11  ? 147 GLU A N    1 
ATOM   3124 C CA   . GLU B 1 147 ? 128.394 134.118 107.219 1.00 36.39  ? 147 GLU A CA   1 
ATOM   3125 C C    . GLU B 1 147 ? 129.011 135.502 107.015 1.00 40.23  ? 147 GLU A C    1 
ATOM   3126 O O    . GLU B 1 147 ? 129.852 135.695 106.123 1.00 47.25  ? 147 GLU A O    1 
ATOM   3127 C CB   . GLU B 1 147 ? 126.985 134.061 106.630 1.00 41.15  ? 147 GLU A CB   1 
ATOM   3128 C CG   . GLU B 1 147 ? 126.842 134.791 105.306 1.00 48.75  ? 147 GLU A CG   1 
ATOM   3129 C CD   . GLU B 1 147 ? 125.405 134.864 104.833 1.00 59.35  ? 147 GLU A CD   1 
ATOM   3130 O OE1  . GLU B 1 147 ? 124.552 134.142 105.392 1.00 59.80  ? 147 GLU A OE1  1 
ATOM   3131 O OE2  . GLU B 1 147 ? 125.128 135.646 103.899 1.00 55.40  ? 147 GLU A OE2  1 
ATOM   3132 N N    . ARG B 1 148 ? 128.615 136.473 107.844 1.00 42.79  ? 148 ARG A N    1 
ATOM   3133 C CA   . ARG B 1 148 ? 129.172 137.818 107.725 1.00 40.88  ? 148 ARG A CA   1 
ATOM   3134 C C    . ARG B 1 148 ? 130.672 137.824 107.994 1.00 43.14  ? 148 ARG A C    1 
ATOM   3135 O O    . ARG B 1 148 ? 131.429 138.537 107.323 1.00 40.58  ? 148 ARG A O    1 
ATOM   3136 C CB   . ARG B 1 148 ? 128.450 138.776 108.674 1.00 34.14  ? 148 ARG A CB   1 
ATOM   3137 C CG   . ARG B 1 148 ? 127.011 139.081 108.281 1.00 29.23  ? 148 ARG A CG   1 
ATOM   3138 C CD   . ARG B 1 148 ? 126.949 140.088 107.142 1.00 33.03  ? 148 ARG A CD   1 
ATOM   3139 N NE   . ARG B 1 148 ? 127.051 139.440 105.839 1.00 41.95  ? 148 ARG A NE   1 
ATOM   3140 C CZ   . ARG B 1 148 ? 127.194 140.085 104.690 1.00 36.84  ? 148 ARG A CZ   1 
ATOM   3141 N NH1  . ARG B 1 148 ? 127.275 141.404 104.641 1.00 38.14  ? 148 ARG A NH1  1 
ATOM   3142 N NH2  . ARG B 1 148 ? 127.267 139.386 103.560 1.00 36.22  ? 148 ARG A NH2  1 
ATOM   3143 N N    . LEU B 1 149 ? 131.115 137.050 108.988 1.00 47.66  ? 149 LEU A N    1 
ATOM   3144 C CA   . LEU B 1 149 ? 132.541 136.977 109.293 1.00 41.96  ? 149 LEU A CA   1 
ATOM   3145 C C    . LEU B 1 149 ? 133.328 136.394 108.129 1.00 38.91  ? 149 LEU A C    1 
ATOM   3146 O O    . LEU B 1 149 ? 134.404 136.896 107.787 1.00 42.13  ? 149 LEU A O    1 
ATOM   3147 C CB   . LEU B 1 149 ? 132.762 136.148 110.559 1.00 38.73  ? 149 LEU A CB   1 
ATOM   3148 C CG   . LEU B 1 149 ? 134.219 135.917 110.958 1.00 37.58  ? 149 LEU A CG   1 
ATOM   3149 C CD1  . LEU B 1 149 ? 134.878 137.226 111.361 1.00 40.78  ? 149 LEU A CD1  1 
ATOM   3150 C CD2  . LEU B 1 149 ? 134.310 134.901 112.082 1.00 38.92  ? 149 LEU A CD2  1 
ATOM   3151 N N    . ILE B 1 150 ? 132.812 135.330 107.509 1.00 38.77  ? 150 ILE A N    1 
ATOM   3152 C CA   . ILE B 1 150 ? 133.505 134.758 106.355 1.00 38.87  ? 150 ILE A CA   1 
ATOM   3153 C C    . ILE B 1 150 ? 133.589 135.776 105.225 1.00 43.38  ? 150 ILE A C    1 
ATOM   3154 O O    . ILE B 1 150 ? 134.639 135.931 104.582 1.00 47.46  ? 150 ILE A O    1 
ATOM   3155 C CB   . ILE B 1 150 ? 132.815 133.458 105.900 1.00 39.71  ? 150 ILE A CB   1 
ATOM   3156 C CG1  . ILE B 1 150 ? 132.965 132.372 106.965 1.00 38.95  ? 150 ILE A CG1  1 
ATOM   3157 C CG2  . ILE B 1 150 ? 133.386 132.982 104.576 1.00 39.89  ? 150 ILE A CG2  1 
ATOM   3158 C CD1  . ILE B 1 150 ? 132.283 131.073 106.605 1.00 40.21  ? 150 ILE A CD1  1 
ATOM   3159 N N    . THR B 1 151 ? 132.491 136.497 104.975 1.00 50.03  ? 151 THR A N    1 
ATOM   3160 C CA   . THR B 1 151 ? 132.499 137.500 103.912 1.00 48.87  ? 151 THR A CA   1 
ATOM   3161 C C    . THR B 1 151 ? 133.522 138.601 104.187 1.00 50.14  ? 151 THR A C    1 
ATOM   3162 O O    . THR B 1 151 ? 134.278 138.998 103.289 1.00 53.34  ? 151 THR A O    1 
ATOM   3163 C CB   . THR B 1 151 ? 131.103 138.097 103.741 1.00 48.89  ? 151 THR A CB   1 
ATOM   3164 O OG1  . THR B 1 151 ? 130.194 137.074 103.319 1.00 54.33  ? 151 THR A OG1  1 
ATOM   3165 C CG2  . THR B 1 151 ? 131.119 139.209 102.706 1.00 45.80  ? 151 THR A CG2  1 
ATOM   3166 N N    . ILE B 1 152 ? 133.566 139.104 105.425 1.00 52.68  ? 152 ILE A N    1 
ATOM   3167 C CA   . ILE B 1 152 ? 134.497 140.184 105.733 1.00 47.24  ? 152 ILE A CA   1 
ATOM   3168 C C    . ILE B 1 152 ? 135.938 139.687 105.684 1.00 51.36  ? 152 ILE A C    1 
ATOM   3169 O O    . ILE B 1 152 ? 136.842 140.429 105.283 1.00 53.16  ? 152 ILE A O    1 
ATOM   3170 C CB   . ILE B 1 152 ? 134.153 140.840 107.086 1.00 49.04  ? 152 ILE A CB   1 
ATOM   3171 C CG1  . ILE B 1 152 ? 134.780 142.231 107.177 1.00 49.66  ? 152 ILE A CG1  1 
ATOM   3172 C CG2  . ILE B 1 152 ? 134.600 139.984 108.260 1.00 45.98  ? 152 ILE A CG2  1 
ATOM   3173 C CD1  . ILE B 1 152 ? 134.258 143.205 106.146 1.00 52.18  ? 152 ILE A CD1  1 
ATOM   3174 N N    . ILE B 1 153 ? 136.183 138.430 106.070 1.00 55.97  ? 153 ILE A N    1 
ATOM   3175 C CA   . ILE B 1 153 ? 137.532 137.876 105.982 1.00 51.77  ? 153 ILE A CA   1 
ATOM   3176 C C    . ILE B 1 153 ? 137.975 137.811 104.527 1.00 54.22  ? 153 ILE A C    1 
ATOM   3177 O O    . ILE B 1 153 ? 139.107 138.184 104.183 1.00 57.12  ? 153 ILE A O    1 
ATOM   3178 C CB   . ILE B 1 153 ? 137.592 136.495 106.658 1.00 48.51  ? 153 ILE A CB   1 
ATOM   3179 C CG1  . ILE B 1 153 ? 137.650 136.650 108.179 1.00 51.38  ? 153 ILE A CG1  1 
ATOM   3180 C CG2  . ILE B 1 153 ? 138.790 135.703 106.158 1.00 49.64  ? 153 ILE A CG2  1 
ATOM   3181 C CD1  . ILE B 1 153 ? 137.876 135.351 108.916 1.00 52.44  ? 153 ILE A CD1  1 
ATOM   3182 N N    . ALA B 1 154 ? 137.088 137.336 103.649 1.00 62.72  ? 154 ALA A N    1 
ATOM   3183 C CA   . ALA B 1 154 ? 137.420 137.279 102.230 1.00 60.33  ? 154 ALA A CA   1 
ATOM   3184 C C    . ALA B 1 154 ? 137.695 138.669 101.671 1.00 57.79  ? 154 ALA A C    1 
ATOM   3185 O O    . ALA B 1 154 ? 138.647 138.862 100.903 1.00 62.84  ? 154 ALA A O    1 
ATOM   3186 C CB   . ALA B 1 154 ? 136.295 136.599 101.452 1.00 61.24  ? 154 ALA A CB   1 
ATOM   3187 N N    . TYR B 1 155 ? 136.870 139.651 102.044 1.00 66.93  ? 155 TYR A N    1 
ATOM   3188 C CA   . TYR B 1 155 ? 137.077 141.013 101.552 1.00 70.42  ? 155 TYR A CA   1 
ATOM   3189 C C    . TYR B 1 155 ? 138.411 141.575 102.032 1.00 70.19  ? 155 TYR A C    1 
ATOM   3190 O O    . TYR B 1 155 ? 139.140 142.211 101.258 1.00 70.19  ? 155 TYR A O    1 
ATOM   3191 C CB   . TYR B 1 155 ? 135.919 141.910 101.994 1.00 69.38  ? 155 TYR A CB   1 
ATOM   3192 C CG   . TYR B 1 155 ? 135.758 143.174 101.171 1.00 72.14  ? 155 TYR A CG   1 
ATOM   3193 C CD1  . TYR B 1 155 ? 136.707 144.188 101.219 1.00 72.17  ? 155 TYR A CD1  1 
ATOM   3194 C CD2  . TYR B 1 155 ? 134.654 143.350 100.347 1.00 73.28  ? 155 TYR A CD2  1 
ATOM   3195 C CE1  . TYR B 1 155 ? 136.560 145.341 100.471 1.00 73.65  ? 155 TYR A CE1  1 
ATOM   3196 C CE2  . TYR B 1 155 ? 134.501 144.498 99.594  1.00 75.57  ? 155 TYR A CE2  1 
ATOM   3197 C CZ   . TYR B 1 155 ? 135.456 145.489 99.659  1.00 77.13  ? 155 TYR A CZ   1 
ATOM   3198 O OH   . TYR B 1 155 ? 135.305 146.635 98.911  1.00 74.02  ? 155 TYR A OH   1 
ATOM   3199 N N    . ILE B 1 156 ? 138.753 141.340 103.302 1.00 69.39  ? 156 ILE A N    1 
ATOM   3200 C CA   . ILE B 1 156 ? 140.016 141.836 103.845 1.00 68.05  ? 156 ILE A CA   1 
ATOM   3201 C C    . ILE B 1 156 ? 141.190 141.200 103.114 1.00 68.79  ? 156 ILE A C    1 
ATOM   3202 O O    . ILE B 1 156 ? 142.157 141.879 102.746 1.00 67.63  ? 156 ILE A O    1 
ATOM   3203 C CB   . ILE B 1 156 ? 140.086 141.583 105.364 1.00 66.18  ? 156 ILE A CB   1 
ATOM   3204 C CG1  . ILE B 1 156 ? 139.361 142.695 106.122 1.00 68.03  ? 156 ILE A CG1  1 
ATOM   3205 C CG2  . ILE B 1 156 ? 141.529 141.478 105.831 1.00 65.86  ? 156 ILE A CG2  1 
ATOM   3206 C CD1  . ILE B 1 156 ? 138.853 142.275 107.483 1.00 67.14  ? 156 ILE A CD1  1 
ATOM   3207 N N    . MET B 1 157 ? 141.128 139.884 102.897 1.00 81.50  ? 157 MET A N    1 
ATOM   3208 C CA   . MET B 1 157 ? 142.219 139.200 102.209 1.00 80.43  ? 157 MET A CA   1 
ATOM   3209 C C    . MET B 1 157 ? 142.374 139.712 100.781 1.00 80.59  ? 157 MET A C    1 
ATOM   3210 O O    . MET B 1 157 ? 143.497 139.935 100.312 1.00 80.71  ? 157 MET A O    1 
ATOM   3211 C CB   . MET B 1 157 ? 141.990 137.691 102.219 1.00 77.34  ? 157 MET A CB   1 
ATOM   3212 C CG   . MET B 1 157 ? 142.725 136.963 103.331 1.00 79.89  ? 157 MET A CG   1 
ATOM   3213 S SD   . MET B 1 157 ? 142.189 135.253 103.536 1.00 91.19  ? 157 MET A SD   1 
ATOM   3214 C CE   . MET B 1 157 ? 141.787 134.814 101.847 1.00 81.97  ? 157 MET A CE   1 
ATOM   3215 N N    . LYS B 1 158 ? 141.255 139.899 100.074 1.00 86.86  ? 158 LYS A N    1 
ATOM   3216 C CA   . LYS B 1 158 ? 141.326 140.405 98.705  1.00 87.21  ? 158 LYS A CA   1 
ATOM   3217 C C    . LYS B 1 158 ? 141.919 141.807 98.665  1.00 88.04  ? 158 LYS A C    1 
ATOM   3218 O O    . LYS B 1 158 ? 142.761 142.109 97.810  1.00 89.44  ? 158 LYS A O    1 
ATOM   3219 C CB   . LYS B 1 158 ? 139.937 140.390 98.066  1.00 86.22  ? 158 LYS A CB   1 
ATOM   3220 C CG   . LYS B 1 158 ? 139.934 140.691 96.574  1.00 87.29  ? 158 LYS A CG   1 
ATOM   3221 C CD   . LYS B 1 158 ? 139.497 142.120 96.295  1.00 86.55  ? 158 LYS A CD   1 
ATOM   3222 C CE   . LYS B 1 158 ? 139.484 142.410 94.802  1.00 86.00  ? 158 LYS A CE   1 
ATOM   3223 N NZ   . LYS B 1 158 ? 138.540 141.519 94.073  1.00 86.19  ? 158 LYS A NZ   1 
ATOM   3224 N N    . SER B 1 159 ? 141.499 142.679 99.586  1.00 89.60  ? 159 SER A N    1 
ATOM   3225 C CA   . SER B 1 159 ? 142.036 144.037 99.611  1.00 90.27  ? 159 SER A CA   1 
ATOM   3226 C C    . SER B 1 159 ? 143.526 144.031 99.926  1.00 90.29  ? 159 SER A C    1 
ATOM   3227 O O    . SER B 1 159 ? 144.300 144.781 99.318  1.00 90.35  ? 159 SER A O    1 
ATOM   3228 C CB   . SER B 1 159 ? 141.274 144.885 100.630 1.00 91.60  ? 159 SER A CB   1 
ATOM   3229 O OG   . SER B 1 159 ? 141.791 146.202 100.683 1.00 91.66  ? 159 SER A OG   1 
ATOM   3230 N N    . CYS B 1 160 ? 143.946 143.188 100.874 1.00 94.91  ? 160 CYS A N    1 
ATOM   3231 C CA   . CYS B 1 160 ? 145.361 143.108 101.219 1.00 96.42  ? 160 CYS A CA   1 
ATOM   3232 C C    . CYS B 1 160 ? 146.191 142.623 100.037 1.00 95.65  ? 160 CYS A C    1 
ATOM   3233 O O    . CYS B 1 160 ? 147.259 143.177 99.751  1.00 95.53  ? 160 CYS A O    1 
ATOM   3234 C CB   . CYS B 1 160 ? 145.556 142.191 102.425 1.00 96.14  ? 160 CYS A CB   1 
ATOM   3235 S SG   . CYS B 1 160 ? 147.267 142.062 102.996 1.00 95.47  ? 160 CYS A SG   1 
ATOM   3236 N N    . HIS B 1 161 ? 145.712 141.591 99.336  1.00 101.02 ? 161 HIS A N    1 
ATOM   3237 C CA   . HIS B 1 161 ? 146.437 141.097 98.168  1.00 102.90 ? 161 HIS A CA   1 
ATOM   3238 C C    . HIS B 1 161 ? 146.513 142.158 97.079  1.00 102.74 ? 161 HIS A C    1 
ATOM   3239 O O    . HIS B 1 161 ? 147.568 142.346 96.458  1.00 101.76 ? 161 HIS A O    1 
ATOM   3240 C CB   . HIS B 1 161 ? 145.777 139.825 97.635  1.00 101.93 ? 161 HIS A CB   1 
ATOM   3241 C CG   . HIS B 1 161 ? 146.426 139.277 96.404  1.00 101.52 ? 161 HIS A CG   1 
ATOM   3242 N ND1  . HIS B 1 161 ? 146.123 139.730 95.138  1.00 101.74 ? 161 HIS A ND1  1 
ATOM   3243 C CD2  . HIS B 1 161 ? 147.369 138.317 96.245  1.00 101.26 ? 161 HIS A CD2  1 
ATOM   3244 C CE1  . HIS B 1 161 ? 146.849 139.071 94.251  1.00 102.18 ? 161 HIS A CE1  1 
ATOM   3245 N NE2  . HIS B 1 161 ? 147.613 138.208 94.897  1.00 103.48 ? 161 HIS A NE2  1 
ATOM   3246 N N    . GLN B 1 162 ? 145.406 142.865 96.831  1.00 106.02 ? 162 GLN A N    1 
ATOM   3247 C CA   . GLN B 1 162 ? 145.409 143.892 95.797  1.00 106.42 ? 162 GLN A CA   1 
ATOM   3248 C C    . GLN B 1 162 ? 146.375 145.016 96.143  1.00 106.62 ? 162 GLN A C    1 
ATOM   3249 O O    . GLN B 1 162 ? 147.093 145.520 95.270  1.00 106.01 ? 162 GLN A O    1 
ATOM   3250 C CB   . GLN B 1 162 ? 143.996 144.441 95.592  1.00 105.98 ? 162 GLN A CB   1 
ATOM   3251 C CG   . GLN B 1 162 ? 143.783 145.117 94.244  1.00 105.93 ? 162 GLN A CG   1 
ATOM   3252 C CD   . GLN B 1 162 ? 144.203 146.575 94.246  1.00 107.41 ? 162 GLN A CD   1 
ATOM   3253 O OE1  . GLN B 1 162 ? 144.320 147.198 95.301  1.00 107.75 ? 162 GLN A OE1  1 
ATOM   3254 N NE2  . GLN B 1 162 ? 144.432 147.126 93.060  1.00 106.24 ? 162 GLN A NE2  1 
ATOM   3255 N N    . ALA B 1 188 ? 134.242 137.714 96.359  1.00 87.98  ? 188 ALA A N    1 
ATOM   3256 C CA   . ALA B 1 188 ? 134.014 137.017 95.101  1.00 91.47  ? 188 ALA A CA   1 
ATOM   3257 C C    . ALA B 1 188 ? 134.670 135.639 95.114  1.00 92.85  ? 188 ALA A C    1 
ATOM   3258 O O    . ALA B 1 188 ? 134.215 134.732 95.810  1.00 90.41  ? 188 ALA A O    1 
ATOM   3259 C CB   . ALA B 1 188 ? 134.535 137.843 93.934  1.00 88.08  ? 188 ALA A CB   1 
ATOM   3260 N N    . GLY B 1 189 ? 135.741 135.489 94.338  1.00 90.77  ? 189 GLY A N    1 
ATOM   3261 C CA   . GLY B 1 189 ? 136.435 134.219 94.243  1.00 88.41  ? 189 GLY A CA   1 
ATOM   3262 C C    . GLY B 1 189 ? 137.600 134.114 95.206  1.00 88.25  ? 189 GLY A C    1 
ATOM   3263 O O    . GLY B 1 189 ? 138.489 133.273 95.032  1.00 86.03  ? 189 GLY A O    1 
ATOM   3264 N N    . TRP B 1 190 ? 137.604 134.970 96.228  1.00 86.54  ? 190 TRP A N    1 
ATOM   3265 C CA   . TRP B 1 190 ? 138.667 135.016 97.224  1.00 83.35  ? 190 TRP A CA   1 
ATOM   3266 C C    . TRP B 1 190 ? 138.244 134.397 98.552  1.00 82.45  ? 190 TRP A C    1 
ATOM   3267 O O    . TRP B 1 190 ? 138.719 134.818 99.612  1.00 85.62  ? 190 TRP A O    1 
ATOM   3268 C CB   . TRP B 1 190 ? 139.131 136.458 97.438  1.00 83.53  ? 190 TRP A CB   1 
ATOM   3269 C CG   . TRP B 1 190 ? 139.608 137.131 96.188  1.00 87.07  ? 190 TRP A CG   1 
ATOM   3270 C CD1  . TRP B 1 190 ? 138.837 137.656 95.191  1.00 86.41  ? 190 TRP A CD1  1 
ATOM   3271 C CD2  . TRP B 1 190 ? 140.970 137.350 95.799  1.00 88.28  ? 190 TRP A CD2  1 
ATOM   3272 N NE1  . TRP B 1 190 ? 139.633 138.189 94.206  1.00 85.42  ? 190 TRP A NE1  1 
ATOM   3273 C CE2  . TRP B 1 190 ? 140.946 138.015 94.556  1.00 87.75  ? 190 TRP A CE2  1 
ATOM   3274 C CE3  . TRP B 1 190 ? 142.204 137.052 96.380  1.00 87.15  ? 190 TRP A CE3  1 
ATOM   3275 C CZ2  . TRP B 1 190 ? 142.111 138.384 93.885  1.00 87.21  ? 190 TRP A CZ2  1 
ATOM   3276 C CZ3  . TRP B 1 190 ? 143.359 137.419 95.713  1.00 86.59  ? 190 TRP A CZ3  1 
ATOM   3277 C CH2  . TRP B 1 190 ? 143.304 138.078 94.479  1.00 87.27  ? 190 TRP A CH2  1 
ATOM   3278 N N    . LYS B 1 191 ? 137.357 133.410 98.515  1.00 71.66  ? 191 LYS A N    1 
ATOM   3279 C CA   . LYS B 1 191 ? 136.904 132.773 99.746  1.00 72.55  ? 191 LYS A CA   1 
ATOM   3280 C C    . LYS B 1 191 ? 138.045 131.991 100.390 1.00 72.11  ? 191 LYS A C    1 
ATOM   3281 O O    . LYS B 1 191 ? 138.714 131.205 99.707  1.00 74.33  ? 191 LYS A O    1 
ATOM   3282 C CB   . LYS B 1 191 ? 135.726 131.844 99.460  1.00 73.44  ? 191 LYS A CB   1 
ATOM   3283 C CG   . LYS B 1 191 ? 134.453 132.558 99.041  1.00 76.81  ? 191 LYS A CG   1 
ATOM   3284 C CD   . LYS B 1 191 ? 133.887 133.397 100.174 1.00 74.58  ? 191 LYS A CD   1 
ATOM   3285 C CE   . LYS B 1 191 ? 132.578 134.058 99.769  1.00 73.14  ? 191 LYS A CE   1 
ATOM   3286 N NZ   . LYS B 1 191 ? 131.993 134.855 100.882 1.00 71.37  ? 191 LYS A NZ   1 
ATOM   3287 N N    . PRO B 1 192 ? 138.297 132.177 101.682 1.00 65.92  ? 192 PRO A N    1 
ATOM   3288 C CA   . PRO B 1 192 ? 139.355 131.412 102.349 1.00 66.91  ? 192 PRO A CA   1 
ATOM   3289 C C    . PRO B 1 192 ? 138.988 129.942 102.482 1.00 65.87  ? 192 PRO A C    1 
ATOM   3290 O O    . PRO B 1 192 ? 137.816 129.558 102.485 1.00 66.80  ? 192 PRO A O    1 
ATOM   3291 C CB   . PRO B 1 192 ? 139.462 132.085 103.722 1.00 64.17  ? 192 PRO A CB   1 
ATOM   3292 C CG   . PRO B 1 192 ? 138.104 132.649 103.958 1.00 62.31  ? 192 PRO A CG   1 
ATOM   3293 C CD   . PRO B 1 192 ? 137.601 133.086 102.607 1.00 63.37  ? 192 PRO A CD   1 
ATOM   3294 N N    . SER B 1 193 ? 140.024 129.112 102.587 1.00 57.63  ? 193 SER A N    1 
ATOM   3295 C CA   . SER B 1 193 ? 139.808 127.689 102.787 1.00 54.48  ? 193 SER A CA   1 
ATOM   3296 C C    . SER B 1 193 ? 139.358 127.420 104.225 1.00 56.37  ? 193 SER A C    1 
ATOM   3297 O O    . SER B 1 193 ? 139.392 128.295 105.093 1.00 61.26  ? 193 SER A O    1 
ATOM   3298 C CB   . SER B 1 193 ? 141.079 126.902 102.470 1.00 56.05  ? 193 SER A CB   1 
ATOM   3299 O OG   . SER B 1 193 ? 142.143 127.287 103.320 1.00 58.18  ? 193 SER A OG   1 
ATOM   3300 N N    . VAL B 1 194 ? 138.936 126.178 104.470 1.00 45.07  ? 194 VAL A N    1 
ATOM   3301 C CA   . VAL B 1 194 ? 138.445 125.807 105.795 1.00 47.15  ? 194 VAL A CA   1 
ATOM   3302 C C    . VAL B 1 194 ? 139.572 125.833 106.822 1.00 50.52  ? 194 VAL A C    1 
ATOM   3303 O O    . VAL B 1 194 ? 139.364 126.211 107.981 1.00 54.75  ? 194 VAL A O    1 
ATOM   3304 C CB   . VAL B 1 194 ? 137.764 124.428 105.729 1.00 47.87  ? 194 VAL A CB   1 
ATOM   3305 C CG1  . VAL B 1 194 ? 137.150 124.063 107.066 1.00 46.57  ? 194 VAL A CG1  1 
ATOM   3306 C CG2  . VAL B 1 194 ? 136.711 124.408 104.630 1.00 48.64  ? 194 VAL A CG2  1 
ATOM   3307 N N    . TYR B 1 195 ? 140.777 125.428 106.418 1.00 49.99  ? 195 TYR A N    1 
ATOM   3308 C CA   . TYR B 1 195 ? 141.909 125.380 107.341 1.00 49.97  ? 195 TYR A CA   1 
ATOM   3309 C C    . TYR B 1 195 ? 142.250 126.771 107.872 1.00 57.01  ? 195 TYR A C    1 
ATOM   3310 O O    . TYR B 1 195 ? 142.459 126.959 109.079 1.00 59.36  ? 195 TYR A O    1 
ATOM   3311 C CB   . TYR B 1 195 ? 143.113 124.750 106.637 1.00 50.71  ? 195 TYR A CB   1 
ATOM   3312 C CG   . TYR B 1 195 ? 144.303 124.471 107.522 1.00 57.20  ? 195 TYR A CG   1 
ATOM   3313 C CD1  . TYR B 1 195 ? 144.243 123.504 108.517 1.00 57.68  ? 195 TYR A CD1  1 
ATOM   3314 C CD2  . TYR B 1 195 ? 145.498 125.159 107.351 1.00 54.34  ? 195 TYR A CD2  1 
ATOM   3315 C CE1  . TYR B 1 195 ? 145.334 123.238 109.324 1.00 59.43  ? 195 TYR A CE1  1 
ATOM   3316 C CE2  . TYR B 1 195 ? 146.592 124.900 108.153 1.00 52.11  ? 195 TYR A CE2  1 
ATOM   3317 C CZ   . TYR B 1 195 ? 146.504 123.941 109.138 1.00 58.69  ? 195 TYR A CZ   1 
ATOM   3318 O OH   . TYR B 1 195 ? 147.590 123.679 109.942 1.00 61.04  ? 195 TYR A OH   1 
ATOM   3319 N N    . TYR B 1 196 ? 142.294 127.762 106.979 1.00 52.91  ? 196 TYR A N    1 
ATOM   3320 C CA   . TYR B 1 196 ? 142.630 129.121 107.392 1.00 51.44  ? 196 TYR A CA   1 
ATOM   3321 C C    . TYR B 1 196 ? 141.542 129.713 108.281 1.00 51.51  ? 196 TYR A C    1 
ATOM   3322 O O    . TYR B 1 196 ? 141.844 130.421 109.249 1.00 58.64  ? 196 TYR A O    1 
ATOM   3323 C CB   . TYR B 1 196 ? 142.860 129.997 106.162 1.00 51.18  ? 196 TYR A CB   1 
ATOM   3324 C CG   . TYR B 1 196 ? 144.107 129.641 105.385 1.00 59.22  ? 196 TYR A CG   1 
ATOM   3325 C CD1  . TYR B 1 196 ? 145.168 128.988 105.999 1.00 58.32  ? 196 TYR A CD1  1 
ATOM   3326 C CD2  . TYR B 1 196 ? 144.221 129.951 104.036 1.00 60.59  ? 196 TYR A CD2  1 
ATOM   3327 C CE1  . TYR B 1 196 ? 146.308 128.658 105.292 1.00 56.11  ? 196 TYR A CE1  1 
ATOM   3328 C CE2  . TYR B 1 196 ? 145.356 129.623 103.323 1.00 59.78  ? 196 TYR A CE2  1 
ATOM   3329 C CZ   . TYR B 1 196 ? 146.397 128.977 103.954 1.00 60.18  ? 196 TYR A CZ   1 
ATOM   3330 O OH   . TYR B 1 196 ? 147.532 128.650 103.247 1.00 60.10  ? 196 TYR A OH   1 
ATOM   3331 N N    . VAL B 1 197 ? 140.276 129.438 107.963 1.00 40.17  ? 197 VAL A N    1 
ATOM   3332 C CA   . VAL B 1 197 ? 139.180 129.905 108.810 1.00 40.33  ? 197 VAL A CA   1 
ATOM   3333 C C    . VAL B 1 197 ? 139.283 129.287 110.198 1.00 42.69  ? 197 VAL A C    1 
ATOM   3334 O O    . VAL B 1 197 ? 139.059 129.962 111.209 1.00 47.40  ? 197 VAL A O    1 
ATOM   3335 C CB   . VAL B 1 197 ? 137.822 129.601 108.152 1.00 42.74  ? 197 VAL A CB   1 
ATOM   3336 C CG1  . VAL B 1 197 ? 136.683 129.994 109.076 1.00 40.58  ? 197 VAL A CG1  1 
ATOM   3337 C CG2  . VAL B 1 197 ? 137.700 130.345 106.835 1.00 45.20  ? 197 VAL A CG2  1 
ATOM   3338 N N    . MET B 1 198 ? 139.630 128.001 110.268 1.00 46.64  ? 198 MET A N    1 
ATOM   3339 C CA   . MET B 1 198 ? 139.794 127.358 111.566 1.00 42.82  ? 198 MET A CA   1 
ATOM   3340 C C    . MET B 1 198 ? 140.928 127.996 112.360 1.00 46.07  ? 198 MET A C    1 
ATOM   3341 O O    . MET B 1 198 ? 140.791 128.243 113.566 1.00 55.52  ? 198 MET A O    1 
ATOM   3342 C CB   . MET B 1 198 ? 140.046 125.860 111.383 1.00 45.76  ? 198 MET A CB   1 
ATOM   3343 C CG   . MET B 1 198 ? 139.688 125.020 112.594 1.00 52.50  ? 198 MET A CG   1 
ATOM   3344 S SD   . MET B 1 198 ? 140.758 123.585 112.800 1.00 67.48  ? 198 MET A SD   1 
ATOM   3345 C CE   . MET B 1 198 ? 142.371 124.334 112.603 1.00 51.57  ? 198 MET A CE   1 
ATOM   3346 N N    . LEU B 1 199 ? 142.055 128.275 111.699 1.00 42.40  ? 199 LEU A N    1 
ATOM   3347 C CA   . LEU B 1 199 ? 143.174 128.910 112.395 1.00 42.85  ? 199 LEU A CA   1 
ATOM   3348 C C    . LEU B 1 199 ? 142.799 130.304 112.898 1.00 45.54  ? 199 LEU A C    1 
ATOM   3349 O O    . LEU B 1 199 ? 143.133 130.679 114.031 1.00 49.46  ? 199 LEU A O    1 
ATOM   3350 C CB   . LEU B 1 199 ? 144.394 128.982 111.476 1.00 39.34  ? 199 LEU A CB   1 
ATOM   3351 C CG   . LEU B 1 199 ? 144.999 127.650 111.026 1.00 44.89  ? 199 LEU A CG   1 
ATOM   3352 C CD1  . LEU B 1 199 ? 146.294 127.881 110.260 1.00 47.01  ? 199 LEU A CD1  1 
ATOM   3353 C CD2  . LEU B 1 199 ? 145.234 126.736 112.216 1.00 44.24  ? 199 LEU A CD2  1 
ATOM   3354 N N    . ILE B 1 200 ? 142.102 131.081 112.068 1.00 41.08  ? 200 ILE A N    1 
ATOM   3355 C CA   . ILE B 1 200 ? 141.701 132.430 112.459 1.00 36.62  ? 200 ILE A CA   1 
ATOM   3356 C C    . ILE B 1 200 ? 140.718 132.382 113.623 1.00 38.37  ? 200 ILE A C    1 
ATOM   3357 O O    . ILE B 1 200 ? 140.805 133.183 114.561 1.00 41.13  ? 200 ILE A O    1 
ATOM   3358 C CB   . ILE B 1 200 ? 141.114 133.180 111.250 1.00 35.94  ? 200 ILE A CB   1 
ATOM   3359 C CG1  . ILE B 1 200 ? 142.217 133.512 110.247 1.00 39.54  ? 200 ILE A CG1  1 
ATOM   3360 C CG2  . ILE B 1 200 ? 140.399 134.450 111.691 1.00 34.88  ? 200 ILE A CG2  1 
ATOM   3361 C CD1  . ILE B 1 200 ? 141.720 134.218 109.010 1.00 36.62  ? 200 ILE A CD1  1 
ATOM   3362 N N    . LEU B 1 201 ? 139.767 131.443 113.585 1.00 35.03  ? 201 LEU A N    1 
ATOM   3363 C CA   . LEU B 1 201 ? 138.819 131.306 114.683 1.00 32.38  ? 201 LEU A CA   1 
ATOM   3364 C C    . LEU B 1 201 ? 139.519 130.892 115.970 1.00 39.01  ? 201 LEU A C    1 
ATOM   3365 O O    . LEU B 1 201 ? 139.169 131.373 117.054 1.00 44.84  ? 201 LEU A O    1 
ATOM   3366 C CB   . LEU B 1 201 ? 137.731 130.299 114.311 1.00 33.01  ? 201 LEU A CB   1 
ATOM   3367 C CG   . LEU B 1 201 ? 136.650 130.809 113.356 1.00 34.11  ? 201 LEU A CG   1 
ATOM   3368 C CD1  . LEU B 1 201 ? 135.755 129.670 112.902 1.00 36.56  ? 201 LEU A CD1  1 
ATOM   3369 C CD2  . LEU B 1 201 ? 135.833 131.911 114.007 1.00 35.49  ? 201 LEU A CD2  1 
ATOM   3370 N N    . CYS B 1 202 ? 140.513 130.006 115.875 1.00 42.66  ? 202 CYS A N    1 
ATOM   3371 C CA   . CYS B 1 202 ? 141.271 129.615 117.060 1.00 37.35  ? 202 CYS A CA   1 
ATOM   3372 C C    . CYS B 1 202 ? 142.007 130.810 117.656 1.00 41.53  ? 202 CYS A C    1 
ATOM   3373 O O    . CYS B 1 202 ? 141.990 131.023 118.877 1.00 44.38  ? 202 CYS A O    1 
ATOM   3374 C CB   . CYS B 1 202 ? 142.255 128.499 116.707 1.00 35.77  ? 202 CYS A CB   1 
ATOM   3375 S SG   . CYS B 1 202 ? 141.502 126.881 116.434 1.00 58.46  ? 202 CYS A SG   1 
ATOM   3376 N N    . THR B 1 203 ? 142.663 131.602 116.804 1.00 39.67  ? 203 THR A N    1 
ATOM   3377 C CA   . THR B 1 203 ? 143.373 132.784 117.291 1.00 34.70  ? 203 THR A CA   1 
ATOM   3378 C C    . THR B 1 203 ? 142.416 133.782 117.933 1.00 41.71  ? 203 THR A C    1 
ATOM   3379 O O    . THR B 1 203 ? 142.711 134.346 118.996 1.00 43.11  ? 203 THR A O    1 
ATOM   3380 C CB   . THR B 1 203 ? 144.150 133.442 116.151 1.00 34.23  ? 203 THR A CB   1 
ATOM   3381 O OG1  . THR B 1 203 ? 144.637 132.433 115.257 1.00 47.44  ? 203 THR A OG1  1 
ATOM   3382 C CG2  . THR B 1 203 ? 145.321 134.240 116.693 1.00 36.62  ? 203 THR A CG2  1 
ATOM   3383 N N    . ALA B 1 204 ? 141.261 134.011 117.302 1.00 43.04  ? 204 ALA A N    1 
ATOM   3384 C CA   . ALA B 1 204 ? 140.281 134.937 117.858 1.00 34.82  ? 204 ALA A CA   1 
ATOM   3385 C C    . ALA B 1 204 ? 139.768 134.451 119.206 1.00 40.62  ? 204 ALA A C    1 
ATOM   3386 O O    . ALA B 1 204 ? 139.623 135.242 120.145 1.00 48.58  ? 204 ALA A O    1 
ATOM   3387 C CB   . ALA B 1 204 ? 139.121 135.127 116.881 1.00 35.87  ? 204 ALA A CB   1 
ATOM   3388 N N    . SER B 1 205 ? 139.485 133.151 119.319 1.00 41.16  ? 205 SER A N    1 
ATOM   3389 C CA   . SER B 1 205 ? 138.999 132.604 120.581 1.00 39.14  ? 205 SER A CA   1 
ATOM   3390 C C    . SER B 1 205 ? 140.041 132.756 121.678 1.00 39.06  ? 205 SER A C    1 
ATOM   3391 O O    . SER B 1 205 ? 139.711 133.136 122.808 1.00 40.59  ? 205 SER A O    1 
ATOM   3392 C CB   . SER B 1 205 ? 138.619 131.135 120.401 1.00 34.83  ? 205 SER A CB   1 
ATOM   3393 O OG   . SER B 1 205 ? 137.678 130.974 119.353 1.00 41.27  ? 205 SER A OG   1 
ATOM   3394 N N    . ILE B 1 206 ? 141.307 132.471 121.360 1.00 39.55  ? 206 ILE A N    1 
ATOM   3395 C CA   . ILE B 1 206 ? 142.370 132.604 122.354 1.00 36.43  ? 206 ILE A CA   1 
ATOM   3396 C C    . ILE B 1 206 ? 142.501 134.054 122.810 1.00 39.28  ? 206 ILE A C    1 
ATOM   3397 O O    . ILE B 1 206 ? 142.603 134.339 124.012 1.00 46.29  ? 206 ILE A O    1 
ATOM   3398 C CB   . ILE B 1 206 ? 143.698 132.067 121.789 1.00 40.56  ? 206 ILE A CB   1 
ATOM   3399 C CG1  . ILE B 1 206 ? 143.652 130.542 121.680 1.00 41.82  ? 206 ILE A CG1  1 
ATOM   3400 C CG2  . ILE B 1 206 ? 144.869 132.503 122.657 1.00 38.05  ? 206 ILE A CG2  1 
ATOM   3401 C CD1  . ILE B 1 206 ? 144.937 129.926 121.181 1.00 42.73  ? 206 ILE A CD1  1 
ATOM   3402 N N    . LEU B 1 207 ? 142.487 134.994 121.859 1.00 37.88  ? 207 LEU A N    1 
ATOM   3403 C CA   . LEU B 1 207 ? 142.624 136.403 122.220 1.00 36.26  ? 207 LEU A CA   1 
ATOM   3404 C C    . LEU B 1 207 ? 141.455 136.874 123.076 1.00 40.89  ? 207 LEU A C    1 
ATOM   3405 O O    . LEU B 1 207 ? 141.651 137.578 124.076 1.00 42.15  ? 207 LEU A O    1 
ATOM   3406 C CB   . LEU B 1 207 ? 142.747 137.262 120.963 1.00 41.20  ? 207 LEU A CB   1 
ATOM   3407 C CG   . LEU B 1 207 ? 144.078 137.197 120.211 1.00 47.55  ? 207 LEU A CG   1 
ATOM   3408 C CD1  . LEU B 1 207 ? 144.054 138.121 119.007 1.00 41.22  ? 207 LEU A CD1  1 
ATOM   3409 C CD2  . LEU B 1 207 ? 145.233 137.547 121.132 1.00 41.67  ? 207 LEU A CD2  1 
ATOM   3410 N N    . ILE B 1 208 ? 140.231 136.487 122.707 1.00 37.63  ? 208 ILE A N    1 
ATOM   3411 C CA   . ILE B 1 208 ? 139.053 136.912 123.459 1.00 36.81  ? 208 ILE A CA   1 
ATOM   3412 C C    . ILE B 1 208 ? 139.078 136.334 124.867 1.00 39.22  ? 208 ILE A C    1 
ATOM   3413 O O    . ILE B 1 208 ? 138.771 137.027 125.844 1.00 43.86  ? 208 ILE A O    1 
ATOM   3414 C CB   . ILE B 1 208 ? 137.765 136.526 122.704 1.00 36.10  ? 208 ILE A CB   1 
ATOM   3415 C CG1  . ILE B 1 208 ? 137.611 137.383 121.447 1.00 37.91  ? 208 ILE A CG1  1 
ATOM   3416 C CG2  . ILE B 1 208 ? 136.544 136.678 123.598 1.00 36.65  ? 208 ILE A CG2  1 
ATOM   3417 C CD1  . ILE B 1 208 ? 136.332 137.124 120.688 1.00 35.57  ? 208 ILE A CD1  1 
ATOM   3418 N N    . SER B 1 209 ? 139.446 135.056 124.994 1.00 42.10  ? 209 SER A N    1 
ATOM   3419 C CA   . SER B 1 209 ? 139.530 134.439 126.313 1.00 35.54  ? 209 SER A CA   1 
ATOM   3420 C C    . SER B 1 209 ? 140.582 135.116 127.183 1.00 34.74  ? 209 SER A C    1 
ATOM   3421 O O    . SER B 1 209 ? 140.336 135.389 128.363 1.00 43.22  ? 209 SER A O    1 
ATOM   3422 C CB   . SER B 1 209 ? 139.832 132.948 126.167 1.00 34.16  ? 209 SER A CB   1 
ATOM   3423 O OG   . SER B 1 209 ? 138.841 132.298 125.390 1.00 45.33  ? 209 SER A OG   1 
ATOM   3424 N N    . CYS B 1 210 ? 141.764 135.386 126.626 1.00 36.36  ? 210 CYS A N    1 
ATOM   3425 C CA   . CYS B 1 210 ? 142.812 136.031 127.419 1.00 35.95  ? 210 CYS A CA   1 
ATOM   3426 C C    . CYS B 1 210 ? 142.469 137.472 127.785 1.00 38.68  ? 210 CYS A C    1 
ATOM   3427 O O    . CYS B 1 210 ? 142.780 137.917 128.899 1.00 38.99  ? 210 CYS A O    1 
ATOM   3428 C CB   . CYS B 1 210 ? 144.142 135.987 126.666 1.00 35.13  ? 210 CYS A CB   1 
ATOM   3429 S SG   . CYS B 1 210 ? 144.936 134.365 126.629 1.00 50.02  ? 210 CYS A SG   1 
ATOM   3430 N N    . CYS B 1 211 ? 141.697 138.162 126.943 1.00 40.92  ? 211 CYS A N    1 
ATOM   3431 C CA   . CYS B 1 211 ? 141.269 139.511 127.293 1.00 40.58  ? 211 CYS A CA   1 
ATOM   3432 C C    . CYS B 1 211 ? 140.165 139.503 128.340 1.00 42.51  ? 211 CYS A C    1 
ATOM   3433 O O    . CYS B 1 211 ? 140.138 140.377 129.213 1.00 47.05  ? 211 CYS A O    1 
ATOM   3434 C CB   . CYS B 1 211 ? 140.805 140.258 126.042 1.00 44.46  ? 211 CYS A CB   1 
ATOM   3435 S SG   . CYS B 1 211 ? 142.149 140.869 125.001 1.00 58.51  ? 211 CYS A SG   1 
ATOM   3436 N N    . ALA B 1 212 ? 139.252 138.535 128.279 1.00 36.19  ? 212 ALA A N    1 
ATOM   3437 C CA   . ALA B 1 212 ? 138.225 138.469 129.310 1.00 32.31  ? 212 ALA A CA   1 
ATOM   3438 C C    . ALA B 1 212 ? 138.832 138.045 130.642 1.00 36.19  ? 212 ALA A C    1 
ATOM   3439 O O    . ALA B 1 212 ? 138.431 138.543 131.699 1.00 32.49  ? 212 ALA A O    1 
ATOM   3440 C CB   . ALA B 1 212 ? 137.113 137.509 128.888 1.00 25.89  ? 212 ALA A CB   1 
ATOM   3441 N N    . SER B 1 213 ? 139.786 137.111 130.605 1.00 32.63  ? 213 SER A N    1 
ATOM   3442 C CA   . SER B 1 213 ? 140.459 136.668 131.821 1.00 24.26  ? 213 SER A CA   1 
ATOM   3443 C C    . SER B 1 213 ? 141.259 137.796 132.463 1.00 32.18  ? 213 SER A C    1 
ATOM   3444 O O    . SER B 1 213 ? 141.312 137.900 133.694 1.00 38.03  ? 213 SER A O    1 
ATOM   3445 C CB   . SER B 1 213 ? 141.362 135.475 131.512 1.00 30.81  ? 213 SER A CB   1 
ATOM   3446 O OG   . SER B 1 213 ? 140.726 134.575 130.623 1.00 36.75  ? 213 SER A OG   1 
ATOM   3447 N N    . ALA B 1 214 ? 141.873 138.662 131.648 1.00 35.01  ? 214 ALA A N    1 
ATOM   3448 C CA   . ALA B 1 214 ? 142.633 139.775 132.209 1.00 31.41  ? 214 ALA A CA   1 
ATOM   3449 C C    . ALA B 1 214 ? 141.759 140.759 132.978 1.00 34.74  ? 214 ALA A C    1 
ATOM   3450 O O    . ALA B 1 214 ? 142.286 141.537 133.781 1.00 39.24  ? 214 ALA A O    1 
ATOM   3451 C CB   . ALA B 1 214 ? 143.384 140.510 131.096 1.00 27.37  ? 214 ALA A CB   1 
ATOM   3452 N N    . MET B 1 215 ? 140.447 140.742 132.763 1.00 34.38  ? 215 MET A N    1 
ATOM   3453 C CA   . MET B 1 215 ? 139.516 141.542 133.548 1.00 34.97  ? 215 MET A CA   1 
ATOM   3454 C C    . MET B 1 215 ? 138.876 140.750 134.680 1.00 36.87  ? 215 MET A C    1 
ATOM   3455 O O    . MET B 1 215 ? 138.687 141.284 135.778 1.00 37.00  ? 215 MET A O    1 
ATOM   3456 C CB   . MET B 1 215 ? 138.427 142.132 132.643 1.00 33.58  ? 215 MET A CB   1 
ATOM   3457 C CG   . MET B 1 215 ? 137.329 142.883 133.385 1.00 34.46  ? 215 MET A CG   1 
ATOM   3458 S SD   . MET B 1 215 ? 135.873 143.199 132.369 1.00 54.62  ? 215 MET A SD   1 
ATOM   3459 C CE   . MET B 1 215 ? 135.123 141.575 132.317 1.00 37.41  ? 215 MET A CE   1 
ATOM   3460 N N    . TYR B 1 216 ? 138.548 139.478 134.432 1.00 37.84  ? 216 TYR A N    1 
ATOM   3461 C CA   . TYR B 1 216 ? 137.946 138.640 135.465 1.00 26.58  ? 216 TYR A CA   1 
ATOM   3462 C C    . TYR B 1 216 ? 138.892 138.417 136.638 1.00 33.18  ? 216 TYR A C    1 
ATOM   3463 O O    . TYR B 1 216 ? 138.461 138.427 137.796 1.00 35.59  ? 216 TYR A O    1 
ATOM   3464 C CB   . TYR B 1 216 ? 137.518 137.297 134.871 1.00 24.63  ? 216 TYR A CB   1 
ATOM   3465 C CG   . TYR B 1 216 ? 136.306 137.365 133.968 1.00 27.89  ? 216 TYR A CG   1 
ATOM   3466 C CD1  . TYR B 1 216 ? 135.255 138.226 134.248 1.00 29.97  ? 216 TYR A CD1  1 
ATOM   3467 C CD2  . TYR B 1 216 ? 136.215 136.565 132.838 1.00 31.09  ? 216 TYR A CD2  1 
ATOM   3468 C CE1  . TYR B 1 216 ? 134.147 138.289 133.426 1.00 28.47  ? 216 TYR A CE1  1 
ATOM   3469 C CE2  . TYR B 1 216 ? 135.115 136.623 132.010 1.00 32.88  ? 216 TYR A CE2  1 
ATOM   3470 C CZ   . TYR B 1 216 ? 134.083 137.484 132.309 1.00 33.63  ? 216 TYR A CZ   1 
ATOM   3471 O OH   . TYR B 1 216 ? 132.983 137.547 131.486 1.00 37.45  ? 216 TYR A OH   1 
ATOM   3472 N N    . THR B 1 217 ? 140.180 138.204 136.365 1.00 34.79  ? 217 THR A N    1 
ATOM   3473 C CA   . THR B 1 217 ? 141.103 137.830 137.435 1.00 29.17  ? 217 THR A CA   1 
ATOM   3474 C C    . THR B 1 217 ? 141.242 138.902 138.512 1.00 30.65  ? 217 THR A C    1 
ATOM   3475 O O    . THR B 1 217 ? 141.139 138.561 139.703 1.00 35.48  ? 217 THR A O    1 
ATOM   3476 C CB   . THR B 1 217 ? 142.463 137.453 136.832 1.00 30.34  ? 217 THR A CB   1 
ATOM   3477 O OG1  . THR B 1 217 ? 142.405 136.118 136.312 1.00 37.14  ? 217 THR A OG1  1 
ATOM   3478 C CG2  . THR B 1 217 ? 143.552 137.520 137.887 1.00 31.26  ? 217 THR A CG2  1 
ATOM   3479 N N    . PRO B 1 218 ? 141.471 140.193 138.194 1.00 33.23  ? 218 PRO A N    1 
ATOM   3480 C CA   . PRO B 1 218 ? 141.595 141.185 139.274 1.00 27.36  ? 218 PRO A CA   1 
ATOM   3481 C C    . PRO B 1 218 ? 140.285 141.478 139.988 1.00 32.65  ? 218 PRO A C    1 
ATOM   3482 O O    . PRO B 1 218 ? 140.243 141.532 141.221 1.00 34.69  ? 218 PRO A O    1 
ATOM   3483 C CB   . PRO B 1 218 ? 142.110 142.429 138.539 1.00 29.16  ? 218 PRO A CB   1 
ATOM   3484 C CG   . PRO B 1 218 ? 142.758 141.885 137.315 1.00 34.54  ? 218 PRO A CG   1 
ATOM   3485 C CD   . PRO B 1 218 ? 141.814 140.805 136.901 1.00 33.75  ? 218 PRO A CD   1 
ATOM   3486 N N    . ILE B 1 219 ? 139.210 141.678 139.219 1.00 32.09  ? 219 ILE A N    1 
ATOM   3487 C CA   . ILE B 1 219 ? 137.932 142.064 139.812 1.00 29.74  ? 219 ILE A CA   1 
ATOM   3488 C C    . ILE B 1 219 ? 137.368 140.942 140.678 1.00 31.92  ? 219 ILE A C    1 
ATOM   3489 O O    . ILE B 1 219 ? 136.897 141.182 141.796 1.00 36.30  ? 219 ILE A O    1 
ATOM   3490 C CB   . ILE B 1 219 ? 136.944 142.486 138.710 1.00 30.55  ? 219 ILE A CB   1 
ATOM   3491 C CG1  . ILE B 1 219 ? 137.423 143.762 138.012 1.00 33.84  ? 219 ILE A CG1  1 
ATOM   3492 C CG2  . ILE B 1 219 ? 135.567 142.702 139.288 1.00 25.71  ? 219 ILE A CG2  1 
ATOM   3493 C CD1  . ILE B 1 219 ? 137.977 144.809 138.950 1.00 34.15  ? 219 ILE A CD1  1 
ATOM   3494 N N    . GLU B 1 220 ? 137.399 139.709 140.183 1.00 35.42  ? 220 GLU A N    1 
ATOM   3495 C CA   . GLU B 1 220 ? 136.998 138.567 140.987 1.00 30.16  ? 220 GLU A CA   1 
ATOM   3496 C C    . GLU B 1 220 ? 138.167 138.090 141.849 1.00 37.87  ? 220 GLU A C    1 
ATOM   3497 O O    . GLU B 1 220 ? 139.298 138.567 141.734 1.00 46.24  ? 220 GLU A O    1 
ATOM   3498 C CB   . GLU B 1 220 ? 136.496 137.430 140.101 1.00 29.46  ? 220 GLU A CB   1 
ATOM   3499 C CG   . GLU B 1 220 ? 135.436 137.847 139.099 1.00 31.28  ? 220 GLU A CG   1 
ATOM   3500 C CD   . GLU B 1 220 ? 134.033 137.545 139.573 1.00 40.74  ? 220 GLU A CD   1 
ATOM   3501 O OE1  . GLU B 1 220 ? 133.885 136.815 140.577 1.00 46.87  ? 220 GLU A OE1  1 
ATOM   3502 O OE2  . GLU B 1 220 ? 133.076 138.038 138.943 1.00 40.26  ? 220 GLU A OE2  1 
ATOM   3503 N N    . GLY B 1 221 ? 137.885 137.136 142.729 1.00 41.19  ? 221 GLY A N    1 
ATOM   3504 C CA   . GLY B 1 221 ? 138.950 136.487 143.467 1.00 41.29  ? 221 GLY A CA   1 
ATOM   3505 C C    . GLY B 1 221 ? 139.420 135.208 142.804 1.00 44.20  ? 221 GLY A C    1 
ATOM   3506 O O    . GLY B 1 221 ? 139.540 134.172 143.465 1.00 50.31  ? 221 GLY A O    1 
ATOM   3507 N N    . TRP B 1 222 ? 139.699 135.267 141.505 1.00 30.29  ? 222 TRP A N    1 
ATOM   3508 C CA   . TRP B 1 222 ? 139.989 134.082 140.713 1.00 31.53  ? 222 TRP A CA   1 
ATOM   3509 C C    . TRP B 1 222 ? 141.436 134.110 140.237 1.00 37.36  ? 222 TRP A C    1 
ATOM   3510 O O    . TRP B 1 222 ? 142.032 135.177 140.064 1.00 46.13  ? 222 TRP A O    1 
ATOM   3511 C CB   . TRP B 1 222 ? 139.057 133.974 139.499 1.00 27.86  ? 222 TRP A CB   1 
ATOM   3512 C CG   . TRP B 1 222 ? 137.609 133.761 139.838 1.00 31.70  ? 222 TRP A CG   1 
ATOM   3513 C CD1  . TRP B 1 222 ? 137.080 133.535 141.073 1.00 32.53  ? 222 TRP A CD1  1 
ATOM   3514 C CD2  . TRP B 1 222 ? 136.509 133.736 138.920 1.00 31.37  ? 222 TRP A CD2  1 
ATOM   3515 N NE1  . TRP B 1 222 ? 135.718 133.386 140.984 1.00 31.81  ? 222 TRP A NE1  1 
ATOM   3516 C CE2  . TRP B 1 222 ? 135.342 133.503 139.673 1.00 27.84  ? 222 TRP A CE2  1 
ATOM   3517 C CE3  . TRP B 1 222 ? 136.396 133.895 137.535 1.00 28.32  ? 222 TRP A CE3  1 
ATOM   3518 C CZ2  . TRP B 1 222 ? 134.080 133.424 139.089 1.00 30.01  ? 222 TRP A CZ2  1 
ATOM   3519 C CZ3  . TRP B 1 222 ? 135.140 133.816 136.957 1.00 24.37  ? 222 TRP A CZ3  1 
ATOM   3520 C CH2  . TRP B 1 222 ? 133.999 133.582 137.733 1.00 28.15  ? 222 TRP A CH2  1 
ATOM   3521 N N    . SER B 1 223 ? 142.000 132.922 140.033 1.00 29.91  ? 223 SER A N    1 
ATOM   3522 C CA   . SER B 1 223 ? 143.290 132.817 139.373 1.00 26.50  ? 223 SER A CA   1 
ATOM   3523 C C    . SER B 1 223 ? 143.111 132.876 137.857 1.00 33.07  ? 223 SER A C    1 
ATOM   3524 O O    . SER B 1 223 ? 142.003 132.753 137.329 1.00 41.45  ? 223 SER A O    1 
ATOM   3525 C CB   . SER B 1 223 ? 144.002 131.530 139.786 1.00 33.62  ? 223 SER A CB   1 
ATOM   3526 O OG   . SER B 1 223 ? 143.286 130.385 139.355 1.00 38.19  ? 223 SER A OG   1 
ATOM   3527 N N    . TYR B 1 224 ? 144.226 133.080 137.153 1.00 29.93  ? 224 TYR A N    1 
ATOM   3528 C CA   . TYR B 1 224 ? 144.165 133.196 135.698 1.00 30.76  ? 224 TYR A CA   1 
ATOM   3529 C C    . TYR B 1 224 ? 143.680 131.899 135.057 1.00 37.18  ? 224 TYR A C    1 
ATOM   3530 O O    . TYR B 1 224 ? 142.869 131.925 134.120 1.00 39.52  ? 224 TYR A O    1 
ATOM   3531 C CB   . TYR B 1 224 ? 145.538 133.587 135.148 1.00 31.04  ? 224 TYR A CB   1 
ATOM   3532 C CG   . TYR B 1 224 ? 145.483 134.215 133.776 1.00 39.71  ? 224 TYR A CG   1 
ATOM   3533 C CD1  . TYR B 1 224 ? 144.980 135.495 133.599 1.00 40.72  ? 224 TYR A CD1  1 
ATOM   3534 C CD2  . TYR B 1 224 ? 145.915 133.520 132.654 1.00 38.26  ? 224 TYR A CD2  1 
ATOM   3535 C CE1  . TYR B 1 224 ? 144.919 136.072 132.347 1.00 38.55  ? 224 TYR A CE1  1 
ATOM   3536 C CE2  . TYR B 1 224 ? 145.857 134.091 131.398 1.00 34.88  ? 224 TYR A CE2  1 
ATOM   3537 C CZ   . TYR B 1 224 ? 145.357 135.366 131.251 1.00 38.70  ? 224 TYR A CZ   1 
ATOM   3538 O OH   . TYR B 1 224 ? 145.299 135.938 130.003 1.00 41.09  ? 224 TYR A OH   1 
ATOM   3539 N N    . PHE B 1 225 ? 144.168 130.756 135.546 1.00 36.77  ? 225 PHE A N    1 
ATOM   3540 C CA   . PHE B 1 225 ? 143.747 129.470 134.994 1.00 34.30  ? 225 PHE A CA   1 
ATOM   3541 C C    . PHE B 1 225 ? 142.267 129.211 135.258 1.00 37.04  ? 225 PHE A C    1 
ATOM   3542 O O    . PHE B 1 225 ? 141.564 128.669 134.398 1.00 43.40  ? 225 PHE A O    1 
ATOM   3543 C CB   . PHE B 1 225 ? 144.609 128.345 135.567 1.00 35.99  ? 225 PHE A CB   1 
ATOM   3544 C CG   . PHE B 1 225 ? 144.205 126.977 135.096 1.00 42.68  ? 225 PHE A CG   1 
ATOM   3545 C CD1  . PHE B 1 225 ? 144.460 126.579 133.795 1.00 38.90  ? 225 PHE A CD1  1 
ATOM   3546 C CD2  . PHE B 1 225 ? 143.575 126.090 135.953 1.00 38.90  ? 225 PHE A CD2  1 
ATOM   3547 C CE1  . PHE B 1 225 ? 144.088 125.325 133.356 1.00 34.19  ? 225 PHE A CE1  1 
ATOM   3548 C CE2  . PHE B 1 225 ? 143.202 124.834 135.519 1.00 36.24  ? 225 PHE A CE2  1 
ATOM   3549 C CZ   . PHE B 1 225 ? 143.459 124.450 134.218 1.00 38.81  ? 225 PHE A CZ   1 
ATOM   3550 N N    . ASP B 1 226 ? 141.780 129.593 136.441 1.00 27.26  ? 226 ASP A N    1 
ATOM   3551 C CA   . ASP B 1 226 ? 140.353 129.475 136.729 1.00 29.15  ? 226 ASP A CA   1 
ATOM   3552 C C    . ASP B 1 226 ? 139.527 130.353 135.799 1.00 35.46  ? 226 ASP A C    1 
ATOM   3553 O O    . ASP B 1 226 ? 138.443 129.958 135.360 1.00 42.41  ? 226 ASP A O    1 
ATOM   3554 C CB   . ASP B 1 226 ? 140.080 129.831 138.190 1.00 33.43  ? 226 ASP A CB   1 
ATOM   3555 C CG   . ASP B 1 226 ? 140.369 128.682 139.136 1.00 41.02  ? 226 ASP A CG   1 
ATOM   3556 O OD1  . ASP B 1 226 ? 140.796 127.610 138.658 1.00 43.08  ? 226 ASP A OD1  1 
ATOM   3557 O OD2  . ASP B 1 226 ? 140.174 128.853 140.357 1.00 41.23  ? 226 ASP A OD2  1 
ATOM   3558 N N    . SER B 1 227 ? 140.025 131.554 135.494 1.00 30.07  ? 227 SER A N    1 
ATOM   3559 C CA   . SER B 1 227 ? 139.326 132.427 134.559 1.00 28.51  ? 227 SER A CA   1 
ATOM   3560 C C    . SER B 1 227 ? 139.269 131.815 133.164 1.00 30.15  ? 227 SER A C    1 
ATOM   3561 O O    . SER B 1 227 ? 138.229 131.875 132.497 1.00 31.72  ? 227 SER A O    1 
ATOM   3562 C CB   . SER B 1 227 ? 139.999 133.798 134.518 1.00 32.03  ? 227 SER A CB   1 
ATOM   3563 O OG   . SER B 1 227 ? 139.990 134.408 135.793 1.00 34.03  ? 227 SER A OG   1 
ATOM   3564 N N    . LEU B 1 228 ? 140.375 131.227 132.702 1.00 29.03  ? 228 LEU A N    1 
ATOM   3565 C CA   . LEU B 1 228 ? 140.358 130.564 131.399 1.00 24.26  ? 228 LEU A CA   1 
ATOM   3566 C C    . LEU B 1 228 ? 139.404 129.372 131.388 1.00 24.69  ? 228 LEU A C    1 
ATOM   3567 O O    . LEU B 1 228 ? 138.692 129.141 130.399 1.00 32.87  ? 228 LEU A O    1 
ATOM   3568 C CB   . LEU B 1 228 ? 141.771 130.126 131.019 1.00 26.40  ? 228 LEU A CB   1 
ATOM   3569 C CG   . LEU B 1 228 ? 142.763 131.236 130.664 1.00 33.95  ? 228 LEU A CG   1 
ATOM   3570 C CD1  . LEU B 1 228 ? 144.182 130.695 130.627 1.00 31.73  ? 228 LEU A CD1  1 
ATOM   3571 C CD2  . LEU B 1 228 ? 142.404 131.883 129.337 1.00 34.55  ? 228 LEU A CD2  1 
ATOM   3572 N N    . TYR B 1 229 ? 139.380 128.599 132.477 1.00 21.06  ? 229 TYR A N    1 
ATOM   3573 C CA   . TYR B 1 229 ? 138.448 127.480 132.584 1.00 22.75  ? 229 TYR A CA   1 
ATOM   3574 C C    . TYR B 1 229 ? 136.998 127.958 132.538 1.00 26.57  ? 229 TYR A C    1 
ATOM   3575 O O    . TYR B 1 229 ? 136.162 127.366 131.842 1.00 23.45  ? 229 TYR A O    1 
ATOM   3576 C CB   . TYR B 1 229 ? 138.737 126.699 133.868 1.00 21.59  ? 229 TYR A CB   1 
ATOM   3577 C CG   . TYR B 1 229 ? 137.745 125.608 134.201 1.00 28.51  ? 229 TYR A CG   1 
ATOM   3578 C CD1  . TYR B 1 229 ? 137.712 124.426 133.475 1.00 23.17  ? 229 TYR A CD1  1 
ATOM   3579 C CD2  . TYR B 1 229 ? 136.866 125.748 135.265 1.00 28.96  ? 229 TYR A CD2  1 
ATOM   3580 C CE1  . TYR B 1 229 ? 136.813 123.426 133.784 1.00 20.53  ? 229 TYR A CE1  1 
ATOM   3581 C CE2  . TYR B 1 229 ? 135.966 124.752 135.582 1.00 30.66  ? 229 TYR A CE2  1 
ATOM   3582 C CZ   . TYR B 1 229 ? 135.945 123.594 134.839 1.00 27.45  ? 229 TYR A CZ   1 
ATOM   3583 O OH   . TYR B 1 229 ? 135.046 122.602 135.159 1.00 28.61  ? 229 TYR A OH   1 
ATOM   3584 N N    . PHE B 1 230 ? 136.690 129.039 133.259 1.00 23.09  ? 230 PHE A N    1 
ATOM   3585 C CA   . PHE B 1 230 ? 135.344 129.604 133.224 1.00 17.82  ? 230 PHE A CA   1 
ATOM   3586 C C    . PHE B 1 230 ? 134.987 130.086 131.826 1.00 23.76  ? 230 PHE A C    1 
ATOM   3587 O O    . PHE B 1 230 ? 133.857 129.892 131.363 1.00 25.64  ? 230 PHE A O    1 
ATOM   3588 C CB   . PHE B 1 230 ? 135.225 130.750 134.227 1.00 23.75  ? 230 PHE A CB   1 
ATOM   3589 C CG   . PHE B 1 230 ? 134.038 131.643 133.994 1.00 32.73  ? 230 PHE A CG   1 
ATOM   3590 C CD1  . PHE B 1 230 ? 132.765 131.240 134.364 1.00 27.70  ? 230 PHE A CD1  1 
ATOM   3591 C CD2  . PHE B 1 230 ? 134.191 132.882 133.390 1.00 28.16  ? 230 PHE A CD2  1 
ATOM   3592 C CE1  . PHE B 1 230 ? 131.672 132.056 134.145 1.00 23.49  ? 230 PHE A CE1  1 
ATOM   3593 C CE2  . PHE B 1 230 ? 133.102 133.701 133.165 1.00 20.64  ? 230 PHE A CE2  1 
ATOM   3594 C CZ   . PHE B 1 230 ? 131.841 133.287 133.543 1.00 21.91  ? 230 PHE A CZ   1 
ATOM   3595 N N    . CYS B 1 231 ? 135.937 130.734 131.145 1.00 30.14  ? 231 CYS A N    1 
ATOM   3596 C CA   . CYS B 1 231 ? 135.685 131.211 129.790 1.00 18.17  ? 231 CYS A CA   1 
ATOM   3597 C C    . CYS B 1 231 ? 135.361 130.053 128.857 1.00 23.12  ? 231 CYS A C    1 
ATOM   3598 O O    . CYS B 1 231 ? 134.421 130.135 128.057 1.00 32.03  ? 231 CYS A O    1 
ATOM   3599 C CB   . CYS B 1 231 ? 136.884 132.005 129.273 1.00 14.22  ? 231 CYS A CB   1 
ATOM   3600 S SG   . CYS B 1 231 ? 137.065 133.645 130.014 1.00 39.87  ? 231 CYS A SG   1 
ATOM   3601 N N    . PHE B 1 232 ? 136.125 128.961 128.947 1.00 24.39  ? 232 PHE A N    1 
ATOM   3602 C CA   . PHE B 1 232 ? 135.845 127.811 128.091 1.00 20.31  ? 232 PHE A CA   1 
ATOM   3603 C C    . PHE B 1 232 ? 134.486 127.198 128.413 1.00 20.36  ? 232 PHE A C    1 
ATOM   3604 O O    . PHE B 1 232 ? 133.734 126.831 127.504 1.00 26.81  ? 232 PHE A O    1 
ATOM   3605 C CB   . PHE B 1 232 ? 136.939 126.752 128.219 1.00 20.42  ? 232 PHE A CB   1 
ATOM   3606 C CG   . PHE B 1 232 ? 136.669 125.516 127.406 1.00 26.85  ? 232 PHE A CG   1 
ATOM   3607 C CD1  . PHE B 1 232 ? 136.895 125.505 126.041 1.00 27.07  ? 232 PHE A CD1  1 
ATOM   3608 C CD2  . PHE B 1 232 ? 136.157 124.374 128.003 1.00 24.84  ? 232 PHE A CD2  1 
ATOM   3609 C CE1  . PHE B 1 232 ? 136.631 124.378 125.289 1.00 22.93  ? 232 PHE A CE1  1 
ATOM   3610 C CE2  . PHE B 1 232 ? 135.891 123.244 127.257 1.00 23.96  ? 232 PHE A CE2  1 
ATOM   3611 C CZ   . PHE B 1 232 ? 136.129 123.246 125.899 1.00 24.20  ? 232 PHE A CZ   1 
ATOM   3612 N N    . VAL B 1 233 ? 134.152 127.078 129.701 1.00 26.34  ? 233 VAL A N    1 
ATOM   3613 C CA   . VAL B 1 233 ? 132.895 126.431 130.072 1.00 21.94  ? 233 VAL A CA   1 
ATOM   3614 C C    . VAL B 1 233 ? 131.701 127.277 129.631 1.00 24.37  ? 233 VAL A C    1 
ATOM   3615 O O    . VAL B 1 233 ? 130.687 126.745 129.165 1.00 21.63  ? 233 VAL A O    1 
ATOM   3616 C CB   . VAL B 1 233 ? 132.862 126.140 131.584 1.00 22.41  ? 233 VAL A CB   1 
ATOM   3617 C CG1  . VAL B 1 233 ? 131.481 125.659 132.005 1.00 14.63  ? 233 VAL A CG1  1 
ATOM   3618 C CG2  . VAL B 1 233 ? 133.906 125.099 131.941 1.00 22.49  ? 233 VAL A CG2  1 
ATOM   3619 N N    . ALA B 1 234 ? 131.802 128.602 129.764 1.00 27.97  ? 234 ALA A N    1 
ATOM   3620 C CA   . ALA B 1 234 ? 130.689 129.467 129.379 1.00 17.68  ? 234 ALA A CA   1 
ATOM   3621 C C    . ALA B 1 234 ? 130.564 129.591 127.866 1.00 24.06  ? 234 ALA A C    1 
ATOM   3622 O O    . ALA B 1 234 ? 129.450 129.572 127.331 1.00 32.70  ? 234 ALA A O    1 
ATOM   3623 C CB   . ALA B 1 234 ? 130.854 130.846 130.018 1.00 17.69  ? 234 ALA A CB   1 
ATOM   3624 N N    . PHE B 1 235 ? 131.690 129.718 127.159 1.00 27.60  ? 235 PHE A N    1 
ATOM   3625 C CA   . PHE B 1 235 ? 131.640 129.971 125.720 1.00 16.60  ? 235 PHE A CA   1 
ATOM   3626 C C    . PHE B 1 235 ? 131.113 128.770 124.944 1.00 22.50  ? 235 PHE A C    1 
ATOM   3627 O O    . PHE B 1 235 ? 130.444 128.945 123.919 1.00 25.63  ? 235 PHE A O    1 
ATOM   3628 C CB   . PHE B 1 235 ? 133.018 130.373 125.197 1.00 13.60  ? 235 PHE A CB   1 
ATOM   3629 C CG   . PHE B 1 235 ? 133.487 131.720 125.673 1.00 23.94  ? 235 PHE A CG   1 
ATOM   3630 C CD1  . PHE B 1 235 ? 132.638 132.564 126.373 1.00 25.16  ? 235 PHE A CD1  1 
ATOM   3631 C CD2  . PHE B 1 235 ? 134.781 132.146 125.414 1.00 24.18  ? 235 PHE A CD2  1 
ATOM   3632 C CE1  . PHE B 1 235 ? 133.073 133.798 126.808 1.00 22.28  ? 235 PHE A CE1  1 
ATOM   3633 C CE2  . PHE B 1 235 ? 135.218 133.382 125.847 1.00 16.56  ? 235 PHE A CE2  1 
ATOM   3634 C CZ   . PHE B 1 235 ? 134.365 134.210 126.545 1.00 20.61  ? 235 PHE A CZ   1 
ATOM   3635 N N    . SER B 1 236 ? 131.406 127.555 125.402 1.00 22.75  ? 236 SER A N    1 
ATOM   3636 C CA   . SER B 1 236 ? 130.935 126.344 124.739 1.00 22.34  ? 236 SER A CA   1 
ATOM   3637 C C    . SER B 1 236 ? 129.480 126.014 125.049 1.00 29.26  ? 236 SER A C    1 
ATOM   3638 O O    . SER B 1 236 ? 128.979 125.000 124.550 1.00 28.26  ? 236 SER A O    1 
ATOM   3639 C CB   . SER B 1 236 ? 131.822 125.159 125.126 1.00 21.75  ? 236 SER A CB   1 
ATOM   3640 O OG   . SER B 1 236 ? 131.818 124.958 126.528 1.00 20.74  ? 236 SER A OG   1 
ATOM   3641 N N    . THR B 1 237 ? 128.797 126.844 125.841 1.00 28.41  ? 237 THR A N    1 
ATOM   3642 C CA   . THR B 1 237 ? 127.396 126.643 126.234 1.00 22.57  ? 237 THR A CA   1 
ATOM   3643 C C    . THR B 1 237 ? 127.193 125.335 126.995 1.00 27.41  ? 237 THR A C    1 
ATOM   3644 O O    . THR B 1 237 ? 126.110 124.751 126.965 1.00 40.49  ? 237 THR A O    1 
ATOM   3645 C CB   . THR B 1 237 ? 126.442 126.708 125.034 1.00 27.75  ? 237 THR A CB   1 
ATOM   3646 O OG1  . THR B 1 237 ? 126.805 125.723 124.058 1.00 34.78  ? 237 THR A OG1  1 
ATOM   3647 C CG2  . THR B 1 237 ? 126.485 128.085 124.392 1.00 23.57  ? 237 THR A CG2  1 
ATOM   3648 N N    . ILE B 1 238 ? 128.228 124.875 127.697 1.00 20.21  ? 238 ILE A N    1 
ATOM   3649 C CA   . ILE B 1 238 ? 128.067 123.753 128.616 1.00 17.78  ? 238 ILE A CA   1 
ATOM   3650 C C    . ILE B 1 238 ? 127.417 124.224 129.911 1.00 27.46  ? 238 ILE A C    1 
ATOM   3651 O O    . ILE B 1 238 ? 126.397 123.678 130.345 1.00 40.08  ? 238 ILE A O    1 
ATOM   3652 C CB   . ILE B 1 238 ? 129.423 123.069 128.872 1.00 20.38  ? 238 ILE A CB   1 
ATOM   3653 C CG1  . ILE B 1 238 ? 129.897 122.349 127.607 1.00 24.67  ? 238 ILE A CG1  1 
ATOM   3654 C CG2  . ILE B 1 238 ? 129.320 122.096 130.035 1.00 11.48  ? 238 ILE A CG2  1 
ATOM   3655 C CD1  . ILE B 1 238 ? 131.195 121.591 127.779 1.00 15.44  ? 238 ILE A CD1  1 
ATOM   3656 N N    . GLY B 1 239 ? 128.000 125.236 130.550 1.00 21.52  ? 239 GLY A N    1 
ATOM   3657 C CA   . GLY B 1 239 ? 127.394 125.880 131.699 1.00 8.65   ? 239 GLY A CA   1 
ATOM   3658 C C    . GLY B 1 239 ? 127.210 125.037 132.944 1.00 23.79  ? 239 GLY A C    1 
ATOM   3659 O O    . GLY B 1 239 ? 126.088 124.913 133.444 1.00 37.54  ? 239 GLY A O    1 
ATOM   3660 N N    . PHE B 1 240 ? 128.298 124.445 133.443 1.00 23.72  ? 240 PHE A N    1 
ATOM   3661 C CA   . PHE B 1 240 ? 128.240 123.672 134.681 1.00 15.94  ? 240 PHE A CA   1 
ATOM   3662 C C    . PHE B 1 240 ? 127.575 124.461 135.804 1.00 26.33  ? 240 PHE A C    1 
ATOM   3663 O O    . PHE B 1 240 ? 126.733 123.930 136.539 1.00 35.21  ? 240 PHE A O    1 
ATOM   3664 C CB   . PHE B 1 240 ? 129.645 123.231 135.098 1.00 20.43  ? 240 PHE A CB   1 
ATOM   3665 C CG   . PHE B 1 240 ? 130.215 122.127 134.256 1.00 20.94  ? 240 PHE A CG   1 
ATOM   3666 C CD1  . PHE B 1 240 ? 129.396 121.135 133.748 1.00 24.05  ? 240 PHE A CD1  1 
ATOM   3667 C CD2  . PHE B 1 240 ? 131.573 122.073 133.987 1.00 18.39  ? 240 PHE A CD2  1 
ATOM   3668 C CE1  . PHE B 1 240 ? 129.917 120.112 132.978 1.00 25.82  ? 240 PHE A CE1  1 
ATOM   3669 C CE2  . PHE B 1 240 ? 132.100 121.053 133.216 1.00 22.78  ? 240 PHE A CE2  1 
ATOM   3670 C CZ   . PHE B 1 240 ? 131.273 120.071 132.712 1.00 21.86  ? 240 PHE A CZ   1 
ATOM   3671 N N    . GLY B 1 241 ? 127.944 125.732 135.959 1.00 27.83  ? 241 GLY A N    1 
ATOM   3672 C CA   . GLY B 1 241 ? 127.396 126.561 137.012 1.00 23.83  ? 241 GLY A CA   1 
ATOM   3673 C C    . GLY B 1 241 ? 128.248 126.680 138.256 1.00 31.45  ? 241 GLY A C    1 
ATOM   3674 O O    . GLY B 1 241 ? 127.863 127.408 139.179 1.00 37.78  ? 241 GLY A O    1 
ATOM   3675 N N    . ASP B 1 242 ? 129.379 125.975 138.321 1.00 30.61  ? 242 ASP A N    1 
ATOM   3676 C CA   . ASP B 1 242 ? 130.270 126.094 139.473 1.00 26.36  ? 242 ASP A CA   1 
ATOM   3677 C C    . ASP B 1 242 ? 130.878 127.489 139.581 1.00 34.81  ? 242 ASP A C    1 
ATOM   3678 O O    . ASP B 1 242 ? 131.038 128.014 140.687 1.00 39.76  ? 242 ASP A O    1 
ATOM   3679 C CB   . ASP B 1 242 ? 131.365 125.027 139.398 1.00 26.00  ? 242 ASP A CB   1 
ATOM   3680 C CG   . ASP B 1 242 ? 131.981 124.914 138.016 1.00 42.09  ? 242 ASP A CG   1 
ATOM   3681 O OD1  . ASP B 1 242 ? 131.355 125.379 137.042 1.00 44.84  ? 242 ASP A OD1  1 
ATOM   3682 O OD2  . ASP B 1 242 ? 133.092 124.358 137.905 1.00 43.01  ? 242 ASP A OD2  1 
ATOM   3683 N N    . LEU B 1 243 ? 131.240 128.099 138.453 1.00 33.83  ? 243 LEU A N    1 
ATOM   3684 C CA   . LEU B 1 243 ? 131.750 129.467 138.419 1.00 28.87  ? 243 LEU A CA   1 
ATOM   3685 C C    . LEU B 1 243 ? 130.808 130.342 137.607 1.00 31.58  ? 243 LEU A C    1 
ATOM   3686 O O    . LEU B 1 243 ? 130.592 130.085 136.417 1.00 39.08  ? 243 LEU A O    1 
ATOM   3687 C CB   . LEU B 1 243 ? 133.162 129.522 137.833 1.00 30.39  ? 243 LEU A CB   1 
ATOM   3688 C CG   . LEU B 1 243 ? 134.289 128.898 138.658 1.00 32.80  ? 243 LEU A CG   1 
ATOM   3689 C CD1  . LEU B 1 243 ? 135.598 128.951 137.891 1.00 31.40  ? 243 LEU A CD1  1 
ATOM   3690 C CD2  . LEU B 1 243 ? 134.426 129.600 139.995 1.00 31.48  ? 243 LEU A CD2  1 
ATOM   3691 N N    . VAL B 1 244 ? 130.240 131.364 138.247 1.00 29.08  ? 244 VAL A N    1 
ATOM   3692 C CA   . VAL B 1 244 ? 129.396 132.351 137.577 1.00 27.96  ? 244 VAL A CA   1 
ATOM   3693 C C    . VAL B 1 244 ? 129.870 133.741 137.982 1.00 30.36  ? 244 VAL A C    1 
ATOM   3694 O O    . VAL B 1 244 ? 130.114 133.999 139.167 1.00 33.99  ? 244 VAL A O    1 
ATOM   3695 C CB   . VAL B 1 244 ? 127.905 132.163 137.925 1.00 27.18  ? 244 VAL A CB   1 
ATOM   3696 C CG1  . VAL B 1 244 ? 127.045 133.151 137.154 1.00 27.95  ? 244 VAL A CG1  1 
ATOM   3697 C CG2  . VAL B 1 244 ? 127.460 130.736 137.640 1.00 29.30  ? 244 VAL A CG2  1 
ATOM   3698 N N    . SER B 1 245 ? 130.007 134.626 137.003 1.00 26.08  ? 245 SER A N    1 
ATOM   3699 C CA   . SER B 1 245 ? 130.522 135.974 137.197 1.00 25.97  ? 245 SER A CA   1 
ATOM   3700 C C    . SER B 1 245 ? 129.405 136.988 137.444 1.00 33.89  ? 245 SER A C    1 
ATOM   3701 O O    . SER B 1 245 ? 128.236 136.759 137.120 1.00 35.57  ? 245 SER A O    1 
ATOM   3702 C CB   . SER B 1 245 ? 131.352 136.409 135.987 1.00 24.98  ? 245 SER A CB   1 
ATOM   3703 O OG   . SER B 1 245 ? 130.557 136.460 134.817 1.00 32.22  ? 245 SER A OG   1 
ATOM   3704 N N    . SER B 1 246 ? 129.791 138.118 138.045 1.00 33.00  ? 246 SER A N    1 
ATOM   3705 C CA   . SER B 1 246 ? 128.908 139.269 138.268 1.00 30.00  ? 246 SER A CA   1 
ATOM   3706 C C    . SER B 1 246 ? 127.751 138.949 139.217 1.00 31.96  ? 246 SER A C    1 
ATOM   3707 O O    . SER B 1 246 ? 126.583 139.188 138.907 1.00 36.70  ? 246 SER A O    1 
ATOM   3708 C CB   . SER B 1 246 ? 128.387 139.815 136.937 1.00 32.04  ? 246 SER A CB   1 
ATOM   3709 O OG   . SER B 1 246 ? 127.966 141.160 137.063 1.00 42.03  ? 246 SER A OG   1 
ATOM   3710 N N    . GLN B 1 247 ? 128.078 138.408 140.390 1.00 40.80  ? 247 GLN A N    1 
ATOM   3711 C CA   . GLN B 1 247 ? 127.062 138.038 141.374 1.00 33.07  ? 247 GLN A CA   1 
ATOM   3712 C C    . GLN B 1 247 ? 127.496 138.409 142.788 1.00 33.00  ? 247 GLN A C    1 
ATOM   3713 O O    . GLN B 1 247 ? 127.341 137.619 143.724 1.00 44.58  ? 247 GLN A O    1 
ATOM   3714 C CB   . GLN B 1 247 ? 126.729 136.548 141.305 1.00 29.81  ? 247 GLN A CB   1 
ATOM   3715 C CG   . GLN B 1 247 ? 126.534 135.990 139.906 1.00 28.46  ? 247 GLN A CG   1 
ATOM   3716 C CD   . GLN B 1 247 ? 125.125 135.489 139.680 1.00 38.62  ? 247 GLN A CD   1 
ATOM   3717 O OE1  . GLN B 1 247 ? 124.657 134.591 140.379 1.00 50.00  ? 247 GLN A OE1  1 
ATOM   3718 N NE2  . GLN B 1 247 ? 124.439 136.068 138.702 1.00 40.20  ? 247 GLN A NE2  1 
ATOM   3719 N N    . ASN B 1 248 ? 128.033 139.617 142.979 1.00 33.43  ? 248 ASN A N    1 
ATOM   3720 C CA   . ASN B 1 248 ? 128.620 139.988 144.264 1.00 34.19  ? 248 ASN A CA   1 
ATOM   3721 C C    . ASN B 1 248 ? 128.010 141.256 144.858 1.00 41.86  ? 248 ASN A C    1 
ATOM   3722 O O    . ASN B 1 248 ? 128.712 142.033 145.511 1.00 53.08  ? 248 ASN A O    1 
ATOM   3723 C CB   . ASN B 1 248 ? 130.134 140.151 144.136 1.00 38.10  ? 248 ASN A CB   1 
ATOM   3724 C CG   . ASN B 1 248 ? 130.888 138.883 144.473 1.00 42.87  ? 248 ASN A CG   1 
ATOM   3725 O OD1  . ASN B 1 248 ? 130.368 137.998 145.151 1.00 46.08  ? 248 ASN A OD1  1 
ATOM   3726 N ND2  . ASN B 1 248 ? 132.124 138.787 143.999 1.00 44.20  ? 248 ASN A ND2  1 
ATOM   3727 N N    . ALA B 1 249 ? 126.713 141.480 144.643 1.00 38.71  ? 249 ALA A N    1 
ATOM   3728 C CA   . ALA B 1 249 ? 125.977 142.628 145.193 1.00 40.62  ? 249 ALA A CA   1 
ATOM   3729 C C    . ALA B 1 249 ? 126.662 143.917 144.748 1.00 47.01  ? 249 ALA A C    1 
ATOM   3730 O O    . ALA B 1 249 ? 126.704 144.178 143.533 1.00 53.26  ? 249 ALA A O    1 
ATOM   3731 C CB   . ALA B 1 249 ? 125.836 142.440 146.704 1.00 35.81  ? 249 ALA A CB   1 
ATOM   3732 N N    . HIS B 1 250 ? 127.177 144.745 145.657 1.00 45.82  ? 250 HIS A N    1 
ATOM   3733 C CA   . HIS B 1 250 ? 127.932 145.928 145.262 1.00 47.17  ? 250 HIS A CA   1 
ATOM   3734 C C    . HIS B 1 250 ? 129.154 145.508 144.458 1.00 43.96  ? 250 HIS A C    1 
ATOM   3735 O O    . HIS B 1 250 ? 129.991 144.743 144.939 1.00 39.55  ? 250 HIS A O    1 
ATOM   3736 C CB   . HIS B 1 250 ? 128.343 146.730 146.498 1.00 46.47  ? 250 HIS A CB   1 
ATOM   3737 C CG   . HIS B 1 250 ? 129.339 147.811 146.216 1.00 49.67  ? 250 HIS A CG   1 
ATOM   3738 N ND1  . HIS B 1 250 ? 130.601 147.822 146.767 1.00 50.90  ? 250 HIS A ND1  1 
ATOM   3739 C CD2  . HIS B 1 250 ? 129.257 148.918 145.438 1.00 46.54  ? 250 HIS A CD2  1 
ATOM   3740 C CE1  . HIS B 1 250 ? 131.256 148.890 146.343 1.00 51.73  ? 250 HIS A CE1  1 
ATOM   3741 N NE2  . HIS B 1 250 ? 130.462 149.569 145.535 1.00 50.61  ? 250 HIS A NE2  1 
ATOM   3742 N N    . TYR B 1 251 ? 129.251 146.015 143.231 1.00 44.15  ? 251 TYR A N    1 
ATOM   3743 C CA   . TYR B 1 251 ? 130.323 145.646 142.314 1.00 40.74  ? 251 TYR A CA   1 
ATOM   3744 C C    . TYR B 1 251 ? 131.037 146.899 141.804 1.00 40.58  ? 251 TYR A C    1 
ATOM   3745 O O    . TYR B 1 251 ? 131.115 147.123 140.598 1.00 42.79  ? 251 TYR A O    1 
ATOM   3746 C CB   . TYR B 1 251 ? 129.764 144.826 141.155 1.00 45.51  ? 251 TYR A CB   1 
ATOM   3747 C CG   . TYR B 1 251 ? 130.442 143.496 140.962 1.00 40.79  ? 251 TYR A CG   1 
ATOM   3748 C CD1  . TYR B 1 251 ? 131.809 143.411 140.747 1.00 32.54  ? 251 TYR A CD1  1 
ATOM   3749 C CD2  . TYR B 1 251 ? 129.709 142.319 140.996 1.00 39.77  ? 251 TYR A CD2  1 
ATOM   3750 C CE1  . TYR B 1 251 ? 132.424 142.191 140.571 1.00 38.43  ? 251 TYR A CE1  1 
ATOM   3751 C CE2  . TYR B 1 251 ? 130.316 141.099 140.820 1.00 31.39  ? 251 TYR A CE2  1 
ATOM   3752 C CZ   . TYR B 1 251 ? 131.672 141.039 140.607 1.00 37.84  ? 251 TYR A CZ   1 
ATOM   3753 O OH   . TYR B 1 251 ? 132.278 139.819 140.434 1.00 44.38  ? 251 TYR A OH   1 
ATOM   3754 N N    . GLU B 1 252 ? 131.610 147.685 142.726 1.00 48.18  ? 252 GLU A N    1 
ATOM   3755 C CA   . GLU B 1 252 ? 132.326 148.906 142.358 1.00 48.25  ? 252 GLU A CA   1 
ATOM   3756 C C    . GLU B 1 252 ? 131.507 149.702 141.349 1.00 53.60  ? 252 GLU A C    1 
ATOM   3757 O O    . GLU B 1 252 ? 130.355 150.050 141.629 1.00 57.31  ? 252 GLU A O    1 
ATOM   3758 C CB   . GLU B 1 252 ? 133.710 148.569 141.792 1.00 46.97  ? 252 GLU A CB   1 
ATOM   3759 C CG   . GLU B 1 252 ? 134.782 149.642 141.981 1.00 50.57  ? 252 GLU A CG   1 
ATOM   3760 C CD   . GLU B 1 252 ? 134.678 150.370 143.307 1.00 55.80  ? 252 GLU A CD   1 
ATOM   3761 O OE1  . GLU B 1 252 ? 133.958 151.387 143.382 1.00 53.56  ? 252 GLU A OE1  1 
ATOM   3762 O OE2  . GLU B 1 252 ? 135.319 149.922 144.280 1.00 56.44  ? 252 GLU A OE2  1 
ATOM   3763 N N    . SER B 1 253 ? 132.086 150.002 140.183 1.00 49.52  ? 253 SER A N    1 
ATOM   3764 C CA   . SER B 1 253 ? 131.407 150.862 139.216 1.00 46.24  ? 253 SER A CA   1 
ATOM   3765 C C    . SER B 1 253 ? 130.078 150.245 138.796 1.00 50.72  ? 253 SER A C    1 
ATOM   3766 O O    . SER B 1 253 ? 129.038 150.915 138.808 1.00 52.29  ? 253 SER A O    1 
ATOM   3767 C CB   . SER B 1 253 ? 132.303 151.101 138.003 1.00 43.70  ? 253 SER A CB   1 
ATOM   3768 O OG   . SER B 1 253 ? 131.635 151.874 137.023 1.00 52.38  ? 253 SER A OG   1 
ATOM   3769 N N    . GLN B 1 254 ? 130.101 148.977 138.385 1.00 45.69  ? 254 GLN A N    1 
ATOM   3770 C CA   . GLN B 1 254 ? 128.903 148.158 138.220 1.00 43.15  ? 254 GLN A CA   1 
ATOM   3771 C C    . GLN B 1 254 ? 128.008 148.596 137.065 1.00 45.88  ? 254 GLN A C    1 
ATOM   3772 O O    . GLN B 1 254 ? 127.027 147.916 136.748 1.00 49.70  ? 254 GLN A O    1 
ATOM   3773 C CB   . GLN B 1 254 ? 128.101 148.144 139.529 1.00 37.82  ? 254 GLN A CB   1 
ATOM   3774 C CG   . GLN B 1 254 ? 127.224 146.922 139.722 1.00 43.08  ? 254 GLN A CG   1 
ATOM   3775 C CD   . GLN B 1 254 ? 126.297 147.058 140.912 1.00 46.60  ? 254 GLN A CD   1 
ATOM   3776 O OE1  . GLN B 1 254 ? 126.010 148.165 141.363 1.00 51.50  ? 254 GLN A OE1  1 
ATOM   3777 N NE2  . GLN B 1 254 ? 125.840 145.931 141.438 1.00 46.05  ? 254 GLN A NE2  1 
ATOM   3778 N N    . GLY B 1 255 ? 128.330 149.710 136.417 1.00 44.98  ? 255 GLY A N    1 
ATOM   3779 C CA   . GLY B 1 255 ? 127.575 150.114 135.249 1.00 38.65  ? 255 GLY A CA   1 
ATOM   3780 C C    . GLY B 1 255 ? 128.245 149.656 133.969 1.00 41.63  ? 255 GLY A C    1 
ATOM   3781 O O    . GLY B 1 255 ? 127.606 149.063 133.096 1.00 46.76  ? 255 GLY A O    1 
ATOM   3782 N N    . LEU B 1 256 ? 129.545 149.934 133.854 1.00 38.02  ? 256 LEU A N    1 
ATOM   3783 C CA   . LEU B 1 256 ? 130.329 149.464 132.718 1.00 34.69  ? 256 LEU A CA   1 
ATOM   3784 C C    . LEU B 1 256 ? 130.677 147.984 132.827 1.00 33.09  ? 256 LEU A C    1 
ATOM   3785 O O    . LEU B 1 256 ? 130.864 147.321 131.800 1.00 40.37  ? 256 LEU A O    1 
ATOM   3786 C CB   . LEU B 1 256 ? 131.613 150.288 132.578 1.00 32.75  ? 256 LEU A CB   1 
ATOM   3787 C CG   . LEU B 1 256 ? 131.582 151.739 132.073 1.00 37.17  ? 256 LEU A CG   1 
ATOM   3788 C CD1  . LEU B 1 256 ? 130.709 152.659 132.919 1.00 37.71  ? 256 LEU A CD1  1 
ATOM   3789 C CD2  . LEU B 1 256 ? 132.996 152.286 131.984 1.00 40.17  ? 256 LEU A CD2  1 
ATOM   3790 N N    . TYR B 1 257 ? 130.768 147.460 134.052 1.00 26.96  ? 257 TYR A N    1 
ATOM   3791 C CA   . TYR B 1 257 ? 131.185 146.075 134.256 1.00 26.36  ? 257 TYR A CA   1 
ATOM   3792 C C    . TYR B 1 257 ? 130.173 145.085 133.683 1.00 34.25  ? 257 TYR A C    1 
ATOM   3793 O O    . TYR B 1 257 ? 130.558 144.112 133.020 1.00 34.50  ? 257 TYR A O    1 
ATOM   3794 C CB   . TYR B 1 257 ? 131.400 145.833 135.752 1.00 26.42  ? 257 TYR A CB   1 
ATOM   3795 C CG   . TYR B 1 257 ? 131.971 144.481 136.110 1.00 33.49  ? 257 TYR A CG   1 
ATOM   3796 C CD1  . TYR B 1 257 ? 133.293 144.168 135.827 1.00 35.95  ? 257 TYR A CD1  1 
ATOM   3797 C CD2  . TYR B 1 257 ? 131.194 143.526 136.753 1.00 30.35  ? 257 TYR A CD2  1 
ATOM   3798 C CE1  . TYR B 1 257 ? 133.821 142.935 136.155 1.00 32.94  ? 257 TYR A CE1  1 
ATOM   3799 C CE2  . TYR B 1 257 ? 131.713 142.293 137.087 1.00 28.37  ? 257 TYR A CE2  1 
ATOM   3800 C CZ   . TYR B 1 257 ? 133.025 142.002 136.786 1.00 32.18  ? 257 TYR A CZ   1 
ATOM   3801 O OH   . TYR B 1 257 ? 133.546 140.775 137.119 1.00 36.77  ? 257 TYR A OH   1 
ATOM   3802 N N    . ARG B 1 258 ? 128.880 145.331 133.898 1.00 32.51  ? 258 ARG A N    1 
ATOM   3803 C CA   . ARG B 1 258 ? 127.856 144.437 133.360 1.00 25.79  ? 258 ARG A CA   1 
ATOM   3804 C C    . ARG B 1 258 ? 127.833 144.483 131.837 1.00 30.22  ? 258 ARG A C    1 
ATOM   3805 O O    . ARG B 1 258 ? 127.690 143.444 131.177 1.00 37.02  ? 258 ARG A O    1 
ATOM   3806 C CB   . ARG B 1 258 ? 126.485 144.805 133.930 1.00 29.07  ? 258 ARG A CB   1 
ATOM   3807 C CG   . ARG B 1 258 ? 126.462 144.956 135.444 1.00 31.09  ? 258 ARG A CG   1 
ATOM   3808 C CD   . ARG B 1 258 ? 125.040 145.061 135.977 1.00 31.56  ? 258 ARG A CD   1 
ATOM   3809 N NE   . ARG B 1 258 ? 124.936 144.624 137.365 1.00 34.08  ? 258 ARG A NE   1 
ATOM   3810 C CZ   . ARG B 1 258 ? 123.968 144.992 138.194 1.00 33.62  ? 258 ARG A CZ   1 
ATOM   3811 N NH1  . ARG B 1 258 ? 123.010 145.821 137.814 1.00 38.87  ? 258 ARG A NH1  1 
ATOM   3812 N NH2  . ARG B 1 258 ? 123.966 144.522 139.439 1.00 30.99  ? 258 ARG A NH2  1 
ATOM   3813 N N    . PHE B 1 259 ? 127.986 145.677 131.263 1.00 32.36  ? 259 PHE A N    1 
ATOM   3814 C CA   . PHE B 1 259 ? 128.029 145.823 129.813 1.00 30.18  ? 259 PHE A CA   1 
ATOM   3815 C C    . PHE B 1 259 ? 129.221 145.080 129.219 1.00 31.60  ? 259 PHE A C    1 
ATOM   3816 O O    . PHE B 1 259 ? 129.090 144.385 128.200 1.00 35.23  ? 259 PHE A O    1 
ATOM   3817 C CB   . PHE B 1 259 ? 128.069 147.314 129.470 1.00 24.55  ? 259 PHE A CB   1 
ATOM   3818 C CG   . PHE B 1 259 ? 128.323 147.608 128.022 1.00 33.96  ? 259 PHE A CG   1 
ATOM   3819 C CD1  . PHE B 1 259 ? 127.352 147.357 127.071 1.00 34.65  ? 259 PHE A CD1  1 
ATOM   3820 C CD2  . PHE B 1 259 ? 129.527 148.156 127.617 1.00 32.11  ? 259 PHE A CD2  1 
ATOM   3821 C CE1  . PHE B 1 259 ? 127.581 147.631 125.740 1.00 33.02  ? 259 PHE A CE1  1 
ATOM   3822 C CE2  . PHE B 1 259 ? 129.764 148.432 126.287 1.00 32.07  ? 259 PHE A CE2  1 
ATOM   3823 C CZ   . PHE B 1 259 ? 128.790 148.169 125.347 1.00 31.12  ? 259 PHE A CZ   1 
ATOM   3824 N N    . ALA B 1 260 ? 130.389 145.197 129.855 1.00 30.09  ? 260 ALA A N    1 
ATOM   3825 C CA   . ALA B 1 260 ? 131.572 144.485 129.380 1.00 28.16  ? 260 ALA A CA   1 
ATOM   3826 C C    . ALA B 1 260 ? 131.395 142.973 129.485 1.00 27.85  ? 260 ALA A C    1 
ATOM   3827 O O    . ALA B 1 260 ? 131.799 142.231 128.580 1.00 38.36  ? 260 ALA A O    1 
ATOM   3828 C CB   . ALA B 1 260 ? 132.804 144.938 130.161 1.00 28.89  ? 260 ALA A CB   1 
ATOM   3829 N N    . ASN B 1 261 ? 130.795 142.499 130.578 1.00 30.11  ? 261 ASN A N    1 
ATOM   3830 C CA   . ASN B 1 261 ? 130.525 141.069 130.726 1.00 33.95  ? 261 ASN A CA   1 
ATOM   3831 C C    . ASN B 1 261 ? 129.608 140.567 129.616 1.00 29.24  ? 261 ASN A C    1 
ATOM   3832 O O    . ASN B 1 261 ? 129.860 139.519 129.004 1.00 32.16  ? 261 ASN A O    1 
ATOM   3833 C CB   . ASN B 1 261 ? 129.911 140.802 132.101 1.00 29.50  ? 261 ASN A CB   1 
ATOM   3834 C CG   . ASN B 1 261 ? 129.904 139.329 132.460 1.00 32.98  ? 261 ASN A CG   1 
ATOM   3835 O OD1  . ASN B 1 261 ? 130.720 138.551 131.967 1.00 41.69  ? 261 ASN A OD1  1 
ATOM   3836 N ND2  . ASN B 1 261 ? 128.975 138.937 133.325 1.00 29.28  ? 261 ASN A ND2  1 
ATOM   3837 N N    . PHE B 1 262 ? 128.544 141.322 129.333 1.00 24.71  ? 262 PHE A N    1 
ATOM   3838 C CA   . PHE B 1 262 ? 127.611 140.957 128.270 1.00 30.73  ? 262 PHE A CA   1 
ATOM   3839 C C    . PHE B 1 262 ? 128.326 140.859 126.927 1.00 35.79  ? 262 PHE A C    1 
ATOM   3840 O O    . PHE B 1 262 ? 128.177 139.867 126.196 1.00 32.00  ? 262 PHE A O    1 
ATOM   3841 C CB   . PHE B 1 262 ? 126.488 141.997 128.219 1.00 27.77  ? 262 PHE A CB   1 
ATOM   3842 C CG   . PHE B 1 262 ? 125.496 141.782 127.113 1.00 34.98  ? 262 PHE A CG   1 
ATOM   3843 C CD1  . PHE B 1 262 ? 124.526 140.798 127.214 1.00 35.51  ? 262 PHE A CD1  1 
ATOM   3844 C CD2  . PHE B 1 262 ? 125.531 142.563 125.971 1.00 34.23  ? 262 PHE A CD2  1 
ATOM   3845 C CE1  . PHE B 1 262 ? 123.613 140.601 126.201 1.00 31.57  ? 262 PHE A CE1  1 
ATOM   3846 C CE2  . PHE B 1 262 ? 124.620 142.368 124.954 1.00 27.99  ? 262 PHE A CE2  1 
ATOM   3847 C CZ   . PHE B 1 262 ? 123.659 141.386 125.069 1.00 26.16  ? 262 PHE A CZ   1 
ATOM   3848 N N    . VAL B 1 263 ? 129.141 141.867 126.605 1.00 38.05  ? 263 VAL A N    1 
ATOM   3849 C CA   . VAL B 1 263 ? 129.830 141.898 125.315 1.00 27.87  ? 263 VAL A CA   1 
ATOM   3850 C C    . VAL B 1 263 ? 130.794 140.721 125.198 1.00 30.00  ? 263 VAL A C    1 
ATOM   3851 O O    . VAL B 1 263 ? 130.840 140.029 124.168 1.00 40.66  ? 263 VAL A O    1 
ATOM   3852 C CB   . VAL B 1 263 ? 130.552 143.245 125.130 1.00 26.28  ? 263 VAL A CB   1 
ATOM   3853 C CG1  . VAL B 1 263 ? 131.523 143.181 123.963 1.00 33.00  ? 263 VAL A CG1  1 
ATOM   3854 C CG2  . VAL B 1 263 ? 129.543 144.366 124.931 1.00 30.87  ? 263 VAL A CG2  1 
ATOM   3855 N N    . PHE B 1 264 ? 131.582 140.482 126.250 1.00 25.77  ? 264 PHE A N    1 
ATOM   3856 C CA   . PHE B 1 264 ? 132.570 139.410 126.211 1.00 22.93  ? 264 PHE A CA   1 
ATOM   3857 C C    . PHE B 1 264 ? 131.908 138.050 126.029 1.00 22.39  ? 264 PHE A C    1 
ATOM   3858 O O    . PHE B 1 264 ? 132.356 137.239 125.206 1.00 30.37  ? 264 PHE A O    1 
ATOM   3859 C CB   . PHE B 1 264 ? 133.406 139.418 127.493 1.00 26.91  ? 264 PHE A CB   1 
ATOM   3860 C CG   . PHE B 1 264 ? 134.537 140.405 127.481 1.00 35.31  ? 264 PHE A CG   1 
ATOM   3861 C CD1  . PHE B 1 264 ? 135.379 140.504 126.386 1.00 31.87  ? 264 PHE A CD1  1 
ATOM   3862 C CD2  . PHE B 1 264 ? 134.770 141.220 128.575 1.00 29.88  ? 264 PHE A CD2  1 
ATOM   3863 C CE1  . PHE B 1 264 ? 136.421 141.410 126.380 1.00 28.76  ? 264 PHE A CE1  1 
ATOM   3864 C CE2  . PHE B 1 264 ? 135.811 142.127 128.575 1.00 28.07  ? 264 PHE A CE2  1 
ATOM   3865 C CZ   . PHE B 1 264 ? 136.639 142.221 127.475 1.00 32.25  ? 264 PHE A CZ   1 
ATOM   3866 N N    . ILE B 1 265 ? 130.827 137.787 126.772 1.00 28.80  ? 265 ILE A N    1 
ATOM   3867 C CA   . ILE B 1 265 ? 130.160 136.493 126.650 1.00 28.64  ? 265 ILE A CA   1 
ATOM   3868 C C    . ILE B 1 265 ? 129.570 136.320 125.255 1.00 29.74  ? 265 ILE A C    1 
ATOM   3869 O O    . ILE B 1 265 ? 129.680 135.243 124.651 1.00 33.06  ? 265 ILE A O    1 
ATOM   3870 C CB   . ILE B 1 265 ? 129.091 136.332 127.749 1.00 30.82  ? 265 ILE A CB   1 
ATOM   3871 C CG1  . ILE B 1 265 ? 129.753 136.270 129.125 1.00 26.83  ? 265 ILE A CG1  1 
ATOM   3872 C CG2  . ILE B 1 265 ? 128.251 135.089 127.507 1.00 31.15  ? 265 ILE A CG2  1 
ATOM   3873 C CD1  . ILE B 1 265 ? 128.797 135.957 130.253 1.00 26.89  ? 265 ILE A CD1  1 
ATOM   3874 N N    . LEU B 1 266 ? 128.963 137.377 124.709 1.00 27.43  ? 266 LEU A N    1 
ATOM   3875 C CA   . LEU B 1 266 ? 128.386 137.282 123.371 1.00 25.15  ? 266 LEU A CA   1 
ATOM   3876 C C    . LEU B 1 266 ? 129.443 136.928 122.326 1.00 28.61  ? 266 LEU A C    1 
ATOM   3877 O O    . LEU B 1 266 ? 129.276 135.977 121.543 1.00 28.14  ? 266 LEU A O    1 
ATOM   3878 C CB   . LEU B 1 266 ? 127.689 138.595 123.015 1.00 26.80  ? 266 LEU A CB   1 
ATOM   3879 C CG   . LEU B 1 266 ? 127.102 138.724 121.610 1.00 26.39  ? 266 LEU A CG   1 
ATOM   3880 C CD1  . LEU B 1 266 ? 125.925 137.785 121.426 1.00 28.53  ? 266 LEU A CD1  1 
ATOM   3881 C CD2  . LEU B 1 266 ? 126.685 140.154 121.345 1.00 22.41  ? 266 LEU A CD2  1 
ATOM   3882 N N    . MET B 1 267 ? 130.555 137.672 122.315 1.00 27.57  ? 267 MET A N    1 
ATOM   3883 C CA   . MET B 1 267 ? 131.599 137.414 121.326 1.00 26.41  ? 267 MET A CA   1 
ATOM   3884 C C    . MET B 1 267 ? 132.209 136.025 121.494 1.00 33.27  ? 267 MET A C    1 
ATOM   3885 O O    . MET B 1 267 ? 132.448 135.321 120.500 1.00 43.69  ? 267 MET A O    1 
ATOM   3886 C CB   . MET B 1 267 ? 132.681 138.492 121.398 1.00 26.68  ? 267 MET A CB   1 
ATOM   3887 C CG   . MET B 1 267 ? 132.143 139.913 121.391 1.00 32.44  ? 267 MET A CG   1 
ATOM   3888 S SD   . MET B 1 267 ? 133.424 141.183 121.385 1.00 54.95  ? 267 MET A SD   1 
ATOM   3889 C CE   . MET B 1 267 ? 134.744 140.347 122.253 1.00 40.66  ? 267 MET A CE   1 
ATOM   3890 N N    . GLY B 1 268 ? 132.467 135.609 122.738 1.00 25.85  ? 268 GLY A N    1 
ATOM   3891 C CA   . GLY B 1 268 ? 133.042 134.292 122.952 1.00 20.44  ? 268 GLY A CA   1 
ATOM   3892 C C    . GLY B 1 268 ? 132.140 133.167 122.481 1.00 22.98  ? 268 GLY A C    1 
ATOM   3893 O O    . GLY B 1 268 ? 132.600 132.212 121.848 1.00 24.44  ? 268 GLY A O    1 
ATOM   3894 N N    . VAL B 1 269 ? 130.838 133.277 122.763 1.00 25.79  ? 269 VAL A N    1 
ATOM   3895 C CA   . VAL B 1 269 ? 129.904 132.240 122.333 1.00 25.70  ? 269 VAL A CA   1 
ATOM   3896 C C    . VAL B 1 269 ? 129.855 132.163 120.812 1.00 29.16  ? 269 VAL A C    1 
ATOM   3897 O O    . VAL B 1 269 ? 129.878 131.068 120.231 1.00 40.21  ? 269 VAL A O    1 
ATOM   3898 C CB   . VAL B 1 269 ? 128.509 132.484 122.939 1.00 32.18  ? 269 VAL A CB   1 
ATOM   3899 C CG1  . VAL B 1 269 ? 127.483 131.564 122.303 1.00 30.77  ? 269 VAL A CG1  1 
ATOM   3900 C CG2  . VAL B 1 269 ? 128.542 132.261 124.442 1.00 30.71  ? 269 VAL A CG2  1 
ATOM   3901 N N    . CYS B 1 270 ? 129.809 133.319 120.139 1.00 34.79  ? 270 CYS A N    1 
ATOM   3902 C CA   . CYS B 1 270 ? 129.808 133.315 118.675 1.00 31.29  ? 270 CYS A CA   1 
ATOM   3903 C C    . CYS B 1 270 ? 131.050 132.618 118.117 1.00 32.44  ? 270 CYS A C    1 
ATOM   3904 O O    . CYS B 1 270 ? 130.954 131.736 117.243 1.00 41.43  ? 270 CYS A O    1 
ATOM   3905 C CB   . CYS B 1 270 ? 129.711 134.748 118.154 1.00 30.34  ? 270 CYS A CB   1 
ATOM   3906 S SG   . CYS B 1 270 ? 128.138 135.568 118.500 1.00 57.72  ? 270 CYS A SG   1 
ATOM   3907 N N    . CYS B 1 271 ? 132.229 132.997 118.619 1.00 24.74  ? 271 CYS A N    1 
ATOM   3908 C CA   . CYS B 1 271 ? 133.473 132.443 118.085 1.00 25.77  ? 271 CYS A CA   1 
ATOM   3909 C C    . CYS B 1 271 ? 133.560 130.939 118.311 1.00 31.52  ? 271 CYS A C    1 
ATOM   3910 O O    . CYS B 1 271 ? 133.959 130.186 117.407 1.00 38.57  ? 271 CYS A O    1 
ATOM   3911 C CB   . CYS B 1 271 ? 134.671 133.157 118.709 1.00 31.86  ? 271 CYS A CB   1 
ATOM   3912 S SG   . CYS B 1 271 ? 134.845 134.885 118.211 1.00 56.02  ? 271 CYS A SG   1 
ATOM   3913 N N    . ILE B 1 272 ? 133.173 130.472 119.500 1.00 27.93  ? 272 ILE A N    1 
ATOM   3914 C CA   . ILE B 1 272 ? 133.288 129.045 119.796 1.00 29.30  ? 272 ILE A CA   1 
ATOM   3915 C C    . ILE B 1 272 ? 132.278 128.241 118.981 1.00 31.26  ? 272 ILE A C    1 
ATOM   3916 O O    . ILE B 1 272 ? 132.576 127.127 118.527 1.00 32.09  ? 272 ILE A O    1 
ATOM   3917 C CB   . ILE B 1 272 ? 133.137 128.801 121.307 1.00 29.57  ? 272 ILE A CB   1 
ATOM   3918 C CG1  . ILE B 1 272 ? 134.325 129.412 122.051 1.00 26.72  ? 272 ILE A CG1  1 
ATOM   3919 C CG2  . ILE B 1 272 ? 133.029 127.313 121.606 1.00 24.20  ? 272 ILE A CG2  1 
ATOM   3920 C CD1  . ILE B 1 272 ? 135.647 128.760 121.719 1.00 23.37  ? 272 ILE A CD1  1 
ATOM   3921 N N    . TYR B 1 273 ? 131.081 128.793 118.765 1.00 31.70  ? 273 TYR A N    1 
ATOM   3922 C CA   . TYR B 1 273 ? 130.104 128.136 117.899 1.00 29.13  ? 273 TYR A CA   1 
ATOM   3923 C C    . TYR B 1 273 ? 130.664 127.934 116.493 1.00 37.56  ? 273 TYR A C    1 
ATOM   3924 O O    . TYR B 1 273 ? 130.586 126.831 115.924 1.00 38.44  ? 273 TYR A O    1 
ATOM   3925 C CB   . TYR B 1 273 ? 128.824 128.976 117.866 1.00 29.58  ? 273 TYR A CB   1 
ATOM   3926 C CG   . TYR B 1 273 ? 127.627 128.314 117.219 1.00 41.62  ? 273 TYR A CG   1 
ATOM   3927 C CD1  . TYR B 1 273 ? 126.809 127.461 117.946 1.00 41.79  ? 273 TYR A CD1  1 
ATOM   3928 C CD2  . TYR B 1 273 ? 127.307 128.558 115.891 1.00 39.54  ? 273 TYR A CD2  1 
ATOM   3929 C CE1  . TYR B 1 273 ? 125.711 126.861 117.366 1.00 40.72  ? 273 TYR A CE1  1 
ATOM   3930 C CE2  . TYR B 1 273 ? 126.211 127.960 115.303 1.00 39.01  ? 273 TYR A CE2  1 
ATOM   3931 C CZ   . TYR B 1 273 ? 125.416 127.115 116.044 1.00 47.90  ? 273 TYR A CZ   1 
ATOM   3932 O OH   . TYR B 1 273 ? 124.322 126.516 115.461 1.00 51.80  ? 273 TYR A OH   1 
ATOM   3933 N N    . SER B 1 274 ? 131.251 128.990 115.921 1.00 37.45  ? 274 SER A N    1 
ATOM   3934 C CA   . SER B 1 274 ? 131.824 128.870 114.581 1.00 31.17  ? 274 SER A CA   1 
ATOM   3935 C C    . SER B 1 274 ? 132.960 127.848 114.543 1.00 32.16  ? 274 SER A C    1 
ATOM   3936 O O    . SER B 1 274 ? 133.061 127.044 113.599 1.00 43.56  ? 274 SER A O    1 
ATOM   3937 C CB   . SER B 1 274 ? 132.313 130.236 114.108 1.00 35.29  ? 274 SER A CB   1 
ATOM   3938 O OG   . SER B 1 274 ? 131.311 131.220 114.277 1.00 40.50  ? 274 SER A OG   1 
ATOM   3939 N N    . LEU B 1 275 ? 133.818 127.856 115.569 1.00 29.54  ? 275 LEU A N    1 
ATOM   3940 C CA   . LEU B 1 275 ? 134.931 126.910 115.609 1.00 32.71  ? 275 LEU A CA   1 
ATOM   3941 C C    . LEU B 1 275 ? 134.429 125.471 115.659 1.00 36.02  ? 275 LEU A C    1 
ATOM   3942 O O    . LEU B 1 275 ? 134.967 124.591 114.973 1.00 38.48  ? 275 LEU A O    1 
ATOM   3943 C CB   . LEU B 1 275 ? 135.831 127.211 116.808 1.00 27.04  ? 275 LEU A CB   1 
ATOM   3944 C CG   . LEU B 1 275 ? 137.096 126.360 116.922 1.00 30.45  ? 275 LEU A CG   1 
ATOM   3945 C CD1  . LEU B 1 275 ? 137.953 126.517 115.677 1.00 29.06  ? 275 LEU A CD1  1 
ATOM   3946 C CD2  . LEU B 1 275 ? 137.888 126.722 118.167 1.00 29.72  ? 275 LEU A CD2  1 
ATOM   3947 N N    . PHE B 1 276 ? 133.398 125.214 116.469 1.00 31.39  ? 276 PHE A N    1 
ATOM   3948 C CA   . PHE B 1 276 ? 132.840 123.869 116.562 1.00 20.42  ? 276 PHE A CA   1 
ATOM   3949 C C    . PHE B 1 276 ? 132.263 123.414 115.227 1.00 25.45  ? 276 PHE A C    1 
ATOM   3950 O O    . PHE B 1 276 ? 132.434 122.252 114.834 1.00 30.80  ? 276 PHE A O    1 
ATOM   3951 C CB   . PHE B 1 276 ? 131.778 123.807 117.658 1.00 24.14  ? 276 PHE A CB   1 
ATOM   3952 C CG   . PHE B 1 276 ? 132.343 123.674 119.043 1.00 29.74  ? 276 PHE A CG   1 
ATOM   3953 C CD1  . PHE B 1 276 ? 133.711 123.612 119.246 1.00 30.28  ? 276 PHE A CD1  1 
ATOM   3954 C CD2  . PHE B 1 276 ? 131.504 123.598 120.141 1.00 26.00  ? 276 PHE A CD2  1 
ATOM   3955 C CE1  . PHE B 1 276 ? 134.230 123.486 120.520 1.00 26.99  ? 276 PHE A CE1  1 
ATOM   3956 C CE2  . PHE B 1 276 ? 132.018 123.471 121.415 1.00 25.05  ? 276 PHE A CE2  1 
ATOM   3957 C CZ   . PHE B 1 276 ? 133.383 123.414 121.605 1.00 24.12  ? 276 PHE A CZ   1 
ATOM   3958 N N    . ASN B 1 277 ? 131.580 124.310 114.509 1.00 33.49  ? 277 ASN A N    1 
ATOM   3959 C CA   . ASN B 1 277 ? 131.035 123.921 113.207 1.00 25.92  ? 277 ASN A CA   1 
ATOM   3960 C C    . ASN B 1 277 ? 132.148 123.545 112.226 1.00 29.55  ? 277 ASN A C    1 
ATOM   3961 O O    . ASN B 1 277 ? 132.052 122.532 111.510 1.00 38.69  ? 277 ASN A O    1 
ATOM   3962 C CB   . ASN B 1 277 ? 130.179 125.055 112.639 1.00 27.59  ? 277 ASN A CB   1 
ATOM   3963 C CG   . ASN B 1 277 ? 128.729 124.964 113.075 1.00 38.44  ? 277 ASN A CG   1 
ATOM   3964 O OD1  . ASN B 1 277 ? 128.426 124.961 114.270 1.00 27.07  ? 277 ASN A OD1  1 
ATOM   3965 N ND2  . ASN B 1 277 ? 127.824 124.896 112.108 1.00 43.84  ? 277 ASN A ND2  1 
ATOM   3966 N N    . VAL B 1 278 ? 133.225 124.335 112.197 1.00 28.09  ? 278 VAL A N    1 
ATOM   3967 C CA   . VAL B 1 278 ? 134.328 124.030 111.284 1.00 27.94  ? 278 VAL A CA   1 
ATOM   3968 C C    . VAL B 1 278 ? 134.983 122.696 111.646 1.00 33.97  ? 278 VAL A C    1 
ATOM   3969 O O    . VAL B 1 278 ? 135.301 121.875 110.766 1.00 38.28  ? 278 VAL A O    1 
ATOM   3970 C CB   . VAL B 1 278 ? 135.345 125.186 111.281 1.00 31.98  ? 278 VAL A CB   1 
ATOM   3971 C CG1  . VAL B 1 278 ? 136.588 124.804 110.503 1.00 37.67  ? 278 VAL A CG1  1 
ATOM   3972 C CG2  . VAL B 1 278 ? 134.713 126.437 110.690 1.00 30.42  ? 278 VAL A CG2  1 
ATOM   3973 N N    . ILE B 1 279 ? 135.188 122.453 112.944 1.00 31.35  ? 279 ILE A N    1 
ATOM   3974 C CA   . ILE B 1 279 ? 135.799 121.193 113.359 1.00 26.80  ? 279 ILE A CA   1 
ATOM   3975 C C    . ILE B 1 279 ? 134.904 120.008 113.012 1.00 32.19  ? 279 ILE A C    1 
ATOM   3976 O O    . ILE B 1 279 ? 135.397 118.935 112.646 1.00 37.80  ? 279 ILE A O    1 
ATOM   3977 C CB   . ILE B 1 279 ? 136.135 121.227 114.864 1.00 28.44  ? 279 ILE A CB   1 
ATOM   3978 C CG1  . ILE B 1 279 ? 137.271 122.212 115.136 1.00 27.47  ? 279 ILE A CG1  1 
ATOM   3979 C CG2  . ILE B 1 279 ? 136.543 119.852 115.359 1.00 29.11  ? 279 ILE A CG2  1 
ATOM   3980 C CD1  . ILE B 1 279 ? 137.411 122.585 116.595 1.00 26.44  ? 279 ILE A CD1  1 
ATOM   3981 N N    . SER B 1 280 ? 133.581 120.183 113.099 1.00 33.94  ? 280 SER A N    1 
ATOM   3982 C CA   . SER B 1 280 ? 132.668 119.113 112.699 1.00 25.26  ? 280 SER A CA   1 
ATOM   3983 C C    . SER B 1 280 ? 132.802 118.791 111.214 1.00 29.07  ? 280 SER A C    1 
ATOM   3984 O O    . SER B 1 280 ? 132.777 117.615 110.817 1.00 34.12  ? 280 SER A O    1 
ATOM   3985 C CB   . SER B 1 280 ? 131.229 119.499 113.038 1.00 23.90  ? 280 SER A CB   1 
ATOM   3986 O OG   . SER B 1 280 ? 130.547 119.985 111.894 1.00 34.91  ? 280 SER A OG   1 
ATOM   3987 N N    . ILE B 1 281 ? 132.949 119.821 110.375 1.00 34.84  ? 281 ILE A N    1 
ATOM   3988 C CA   . ILE B 1 281 ? 133.160 119.574 108.946 1.00 34.39  ? 281 ILE A CA   1 
ATOM   3989 C C    . ILE B 1 281 ? 134.441 118.769 108.721 1.00 36.93  ? 281 ILE A C    1 
ATOM   3990 O O    . ILE B 1 281 ? 134.467 117.796 107.943 1.00 43.87  ? 281 ILE A O    1 
ATOM   3991 C CB   . ILE B 1 281 ? 133.188 120.908 108.176 1.00 35.35  ? 281 ILE A CB   1 
ATOM   3992 C CG1  . ILE B 1 281 ? 131.808 121.564 108.203 1.00 34.75  ? 281 ILE A CG1  1 
ATOM   3993 C CG2  . ILE B 1 281 ? 133.641 120.690 106.739 1.00 35.02  ? 281 ILE A CG2  1 
ATOM   3994 C CD1  . ILE B 1 281 ? 131.750 122.887 107.478 1.00 38.42  ? 281 ILE A CD1  1 
ATOM   3995 N N    . LEU B 1 282 ? 135.519 119.151 109.411 1.00 29.90  ? 282 LEU A N    1 
ATOM   3996 C CA   . LEU B 1 282 ? 136.777 118.424 109.261 1.00 32.98  ? 282 LEU A CA   1 
ATOM   3997 C C    . LEU B 1 282 ? 136.651 116.972 109.725 1.00 34.91  ? 282 LEU A C    1 
ATOM   3998 O O    . LEU B 1 282 ? 137.210 116.058 109.105 1.00 38.74  ? 282 LEU A O    1 
ATOM   3999 C CB   . LEU B 1 282 ? 137.889 119.140 110.031 1.00 37.48  ? 282 LEU A CB   1 
ATOM   4000 C CG   . LEU B 1 282 ? 138.452 120.399 109.364 1.00 37.31  ? 282 LEU A CG   1 
ATOM   4001 C CD1  . LEU B 1 282 ? 139.567 120.995 110.200 1.00 37.59  ? 282 LEU A CD1  1 
ATOM   4002 C CD2  . LEU B 1 282 ? 138.933 120.097 107.956 1.00 33.92  ? 282 LEU A CD2  1 
ATOM   4003 N N    . ILE B 1 283 ? 135.910 116.742 110.813 1.00 35.68  ? 283 ILE A N    1 
ATOM   4004 C CA   . ILE B 1 283 ? 135.716 115.381 111.313 1.00 31.03  ? 283 ILE A CA   1 
ATOM   4005 C C    . ILE B 1 283 ? 134.940 114.542 110.305 1.00 30.47  ? 283 ILE A C    1 
ATOM   4006 O O    . ILE B 1 283 ? 135.226 113.352 110.115 1.00 35.33  ? 283 ILE A O    1 
ATOM   4007 C CB   . ILE B 1 283 ? 135.015 115.413 112.685 1.00 27.14  ? 283 ILE A CB   1 
ATOM   4008 C CG1  . ILE B 1 283 ? 135.966 115.944 113.756 1.00 31.26  ? 283 ILE A CG1  1 
ATOM   4009 C CG2  . ILE B 1 283 ? 134.510 114.027 113.069 1.00 26.61  ? 283 ILE A CG2  1 
ATOM   4010 C CD1  . ILE B 1 283 ? 135.376 115.943 115.145 1.00 31.13  ? 283 ILE A CD1  1 
ATOM   4011 N N    . LYS B 1 284 ? 133.946 115.141 109.641 1.00 33.90  ? 284 LYS A N    1 
ATOM   4012 C CA   . LYS B 1 284 ? 133.221 114.402 108.608 1.00 32.18  ? 284 LYS A CA   1 
ATOM   4013 C C    . LYS B 1 284 ? 134.144 114.001 107.464 1.00 32.77  ? 284 LYS A C    1 
ATOM   4014 O O    . LYS B 1 284 ? 134.069 112.870 106.954 1.00 36.15  ? 284 LYS A O    1 
ATOM   4015 C CB   . LYS B 1 284 ? 132.048 115.230 108.085 1.00 27.16  ? 284 LYS A CB   1 
ATOM   4016 C CG   . LYS B 1 284 ? 131.163 114.478 107.104 1.00 27.97  ? 284 LYS A CG   1 
ATOM   4017 C CD   . LYS B 1 284 ? 130.439 115.425 106.164 1.00 35.57  ? 284 LYS A CD   1 
ATOM   4018 C CE   . LYS B 1 284 ? 129.387 114.696 105.347 1.00 35.57  ? 284 LYS A CE   1 
ATOM   4019 N NZ   . LYS B 1 284 ? 128.311 114.126 106.203 1.00 36.04  ? 284 LYS A NZ   1 
ATOM   4020 N N    . GLN B 1 285 ? 135.029 114.912 107.045 1.00 37.86  ? 285 GLN A N    1 
ATOM   4021 C CA   . GLN B 1 285 ? 135.996 114.552 106.006 1.00 35.80  ? 285 GLN A CA   1 
ATOM   4022 C C    . GLN B 1 285 ? 136.905 113.409 106.455 1.00 39.42  ? 285 GLN A C    1 
ATOM   4023 O O    . GLN B 1 285 ? 137.210 112.495 105.670 1.00 40.50  ? 285 GLN A O    1 
ATOM   4024 C CB   . GLN B 1 285 ? 136.825 115.770 105.596 1.00 36.93  ? 285 GLN A CB   1 
ATOM   4025 C CG   . GLN B 1 285 ? 136.023 116.858 104.905 1.00 43.67  ? 285 GLN A CG   1 
ATOM   4026 C CD   . GLN B 1 285 ? 136.903 117.875 104.205 1.00 52.89  ? 285 GLN A CD   1 
ATOM   4027 O OE1  . GLN B 1 285 ? 138.126 117.746 104.189 1.00 53.84  ? 285 GLN A OE1  1 
ATOM   4028 N NE2  . GLN B 1 285 ? 136.282 118.892 103.621 1.00 50.08  ? 285 GLN A NE2  1 
ATOM   4029 N N    . SER B 1 286 ? 137.345 113.439 107.714 1.00 40.05  ? 286 SER A N    1 
ATOM   4030 C CA   . SER B 1 286 ? 138.199 112.362 108.218 1.00 32.16  ? 286 SER A CA   1 
ATOM   4031 C C    . SER B 1 286 ? 137.458 111.030 108.235 1.00 38.22  ? 286 SER A C    1 
ATOM   4032 O O    . SER B 1 286 ? 138.043 109.983 107.929 1.00 42.35  ? 286 SER A O    1 
ATOM   4033 C CB   . SER B 1 286 ? 138.716 112.703 109.616 1.00 37.96  ? 286 SER A CB   1 
ATOM   4034 O OG   . SER B 1 286 ? 137.647 112.918 110.518 1.00 42.59  ? 286 SER A OG   1 
ATOM   4035 N N    . LEU B 1 287 ? 136.176 111.046 108.610 1.00 42.33  ? 287 LEU A N    1 
ATOM   4036 C CA   . LEU B 1 287 ? 135.383 109.818 108.570 1.00 34.08  ? 287 LEU A CA   1 
ATOM   4037 C C    . LEU B 1 287 ? 135.276 109.276 107.149 1.00 35.06  ? 287 LEU A C    1 
ATOM   4038 O O    . LEU B 1 287 ? 135.358 108.058 106.933 1.00 38.24  ? 287 LEU A O    1 
ATOM   4039 C CB   . LEU B 1 287 ? 133.990 110.069 109.142 1.00 34.83  ? 287 LEU A CB   1 
ATOM   4040 C CG   . LEU B 1 287 ? 133.853 110.155 110.658 1.00 33.06  ? 287 LEU A CG   1 
ATOM   4041 C CD1  . LEU B 1 287 ? 132.402 110.385 111.029 1.00 33.64  ? 287 LEU A CD1  1 
ATOM   4042 C CD2  . LEU B 1 287 ? 134.383 108.889 111.306 1.00 35.75  ? 287 LEU A CD2  1 
ATOM   4043 N N    . ASN B 1 288 ? 135.077 110.163 106.170 1.00 45.70  ? 288 ASN A N    1 
ATOM   4044 C CA   . ASN B 1 288 ? 135.036 109.709 104.781 1.00 41.38  ? 288 ASN A CA   1 
ATOM   4045 C C    . ASN B 1 288 ? 136.351 109.051 104.376 1.00 44.47  ? 288 ASN A C    1 
ATOM   4046 O O    . ASN B 1 288 ? 136.356 107.999 103.719 1.00 45.12  ? 288 ASN A O    1 
ATOM   4047 C CB   . ASN B 1 288 ? 134.718 110.878 103.846 1.00 42.00  ? 288 ASN A CB   1 
ATOM   4048 C CG   . ASN B 1 288 ? 133.233 111.044 103.606 1.00 47.01  ? 288 ASN A CG   1 
ATOM   4049 O OD1  . ASN B 1 288 ? 132.487 110.066 103.561 1.00 54.27  ? 288 ASN A OD1  1 
ATOM   4050 N ND2  . ASN B 1 288 ? 132.797 112.285 103.433 1.00 47.41  ? 288 ASN A ND2  1 
ATOM   4051 N N    . TRP B 1 289 ? 137.477 109.654 104.767 1.00 48.02  ? 289 TRP A N    1 
ATOM   4052 C CA   . TRP B 1 289 ? 138.775 109.055 104.457 1.00 46.93  ? 289 TRP A CA   1 
ATOM   4053 C C    . TRP B 1 289 ? 138.929 107.688 105.117 1.00 48.78  ? 289 TRP A C    1 
ATOM   4054 O O    . TRP B 1 289 ? 139.428 106.741 104.495 1.00 54.66  ? 289 TRP A O    1 
ATOM   4055 C CB   . TRP B 1 289 ? 139.905 109.981 104.898 1.00 51.79  ? 289 TRP A CB   1 
ATOM   4056 C CG   . TRP B 1 289 ? 141.262 109.426 104.602 1.00 54.73  ? 289 TRP A CG   1 
ATOM   4057 C CD1  . TRP B 1 289 ? 141.913 109.441 103.403 1.00 51.93  ? 289 TRP A CD1  1 
ATOM   4058 C CD2  . TRP B 1 289 ? 142.127 108.742 105.518 1.00 55.68  ? 289 TRP A CD2  1 
ATOM   4059 N NE1  . TRP B 1 289 ? 143.134 108.823 103.517 1.00 48.01  ? 289 TRP A NE1  1 
ATOM   4060 C CE2  . TRP B 1 289 ? 143.290 108.384 104.807 1.00 51.76  ? 289 TRP A CE2  1 
ATOM   4061 C CE3  . TRP B 1 289 ? 142.035 108.405 106.872 1.00 53.32  ? 289 TRP A CE3  1 
ATOM   4062 C CZ2  . TRP B 1 289 ? 144.350 107.705 105.402 1.00 52.64  ? 289 TRP A CZ2  1 
ATOM   4063 C CZ3  . TRP B 1 289 ? 143.087 107.731 107.462 1.00 52.73  ? 289 TRP A CZ3  1 
ATOM   4064 C CH2  . TRP B 1 289 ? 144.231 107.387 106.727 1.00 53.56  ? 289 TRP A CH2  1 
ATOM   4065 N N    . ILE B 1 290 ? 138.501 107.567 106.376 1.00 53.97  ? 290 ILE A N    1 
ATOM   4066 C CA   . ILE B 1 290 ? 138.610 106.293 107.086 1.00 52.94  ? 290 ILE A CA   1 
ATOM   4067 C C    . ILE B 1 290 ? 137.798 105.218 106.379 1.00 52.17  ? 290 ILE A C    1 
ATOM   4068 O O    . ILE B 1 290 ? 138.259 104.084 106.202 1.00 50.31  ? 290 ILE A O    1 
ATOM   4069 C CB   . ILE B 1 290 ? 138.181 106.456 108.558 1.00 51.99  ? 290 ILE A CB   1 
ATOM   4070 C CG1  . ILE B 1 290 ? 139.378 106.835 109.427 1.00 54.17  ? 290 ILE A CG1  1 
ATOM   4071 C CG2  . ILE B 1 290 ? 137.560 105.171 109.087 1.00 50.52  ? 290 ILE A CG2  1 
ATOM   4072 C CD1  . ILE B 1 290 ? 139.011 107.120 110.865 1.00 50.49  ? 290 ILE A CD1  1 
ATOM   4073 N N    . LEU B 1 291 ? 136.571 105.552 105.968 1.00 56.81  ? 291 LEU A N    1 
ATOM   4074 C CA   . LEU B 1 291 ? 135.748 104.576 105.261 1.00 51.50  ? 291 LEU A CA   1 
ATOM   4075 C C    . LEU B 1 291 ? 136.382 104.168 103.939 1.00 52.44  ? 291 LEU A C    1 
ATOM   4076 O O    . LEU B 1 291 ? 136.397 102.981 103.591 1.00 54.06  ? 291 LEU A O    1 
ATOM   4077 C CB   . LEU B 1 291 ? 134.344 105.130 105.024 1.00 48.53  ? 291 LEU A CB   1 
ATOM   4078 C CG   . LEU B 1 291 ? 133.359 105.044 106.189 1.00 47.83  ? 291 LEU A CG   1 
ATOM   4079 C CD1  . LEU B 1 291 ? 132.011 105.603 105.775 1.00 49.95  ? 291 LEU A CD1  1 
ATOM   4080 C CD2  . LEU B 1 291 ? 133.223 103.606 106.659 1.00 48.38  ? 291 LEU A CD2  1 
ATOM   4081 N N    . ARG B 1 292 ? 136.912 105.135 103.184 1.00 65.48  ? 292 ARG A N    1 
ATOM   4082 C CA   . ARG B 1 292 ? 137.522 104.806 101.898 1.00 64.60  ? 292 ARG A CA   1 
ATOM   4083 C C    . ARG B 1 292 ? 138.746 103.909 102.058 1.00 64.50  ? 292 ARG A C    1 
ATOM   4084 O O    . ARG B 1 292 ? 138.938 102.970 101.276 1.00 64.12  ? 292 ARG A O    1 
ATOM   4085 C CB   . ARG B 1 292 ? 137.882 106.079 101.131 1.00 65.40  ? 292 ARG A CB   1 
ATOM   4086 C CG   . ARG B 1 292 ? 137.768 105.912 99.619  1.00 66.93  ? 292 ARG A CG   1 
ATOM   4087 C CD   . ARG B 1 292 ? 137.465 107.217 98.905  1.00 68.09  ? 292 ARG A CD   1 
ATOM   4088 N NE   . ARG B 1 292 ? 136.227 107.829 99.371  1.00 71.65  ? 292 ARG A NE   1 
ATOM   4089 C CZ   . ARG B 1 292 ? 135.983 109.133 99.356  1.00 71.10  ? 292 ARG A CZ   1 
ATOM   4090 N NH1  . ARG B 1 292 ? 136.883 109.999 98.920  1.00 68.05  ? 292 ARG A NH1  1 
ATOM   4091 N NH2  . ARG B 1 292 ? 134.808 109.578 99.791  1.00 67.32  ? 292 ARG A NH2  1 
ATOM   4092 N N    . LYS B 1 293 ? 139.590 104.184 103.056 1.00 72.19  ? 293 LYS A N    1 
ATOM   4093 C CA   . LYS B 1 293 ? 140.790 103.372 103.242 1.00 75.15  ? 293 LYS A CA   1 
ATOM   4094 C C    . LYS B 1 293 ? 140.458 101.928 103.611 1.00 74.36  ? 293 LYS A C    1 
ATOM   4095 O O    . LYS B 1 293 ? 141.068 100.992 103.079 1.00 76.01  ? 293 LYS A O    1 
ATOM   4096 C CB   . LYS B 1 293 ? 141.694 103.997 104.302 1.00 74.22  ? 293 LYS A CB   1 
ATOM   4097 C CG   . LYS B 1 293 ? 142.924 103.159 104.632 1.00 73.94  ? 293 LYS A CG   1 
ATOM   4098 C CD   . LYS B 1 293 ? 143.799 102.933 103.407 1.00 73.71  ? 293 LYS A CD   1 
ATOM   4099 C CE   . LYS B 1 293 ? 144.358 104.240 102.871 1.00 73.42  ? 293 LYS A CE   1 
ATOM   4100 N NZ   . LYS B 1 293 ? 145.197 104.935 103.883 1.00 73.02  ? 293 LYS A NZ   1 
ATOM   4101 N N    . MET B 1 294 ? 139.501 101.721 104.512 1.00 79.24  ? 294 MET A N    1 
ATOM   4102 C CA   . MET B 1 294 ? 139.172 100.368 104.945 1.00 78.60  ? 294 MET A CA   1 
ATOM   4103 C C    . MET B 1 294 ? 138.422 99.613  103.852 1.00 80.59  ? 294 MET A C    1 
ATOM   4104 O O    . MET B 1 294 ? 137.470 100.132 103.263 1.00 80.80  ? 294 MET A O    1 
ATOM   4105 C CB   . MET B 1 294 ? 138.336 100.409 106.226 1.00 78.30  ? 294 MET A CB   1 
ATOM   4106 C CG   . MET B 1 294 ? 137.573 99.126  106.514 1.00 78.69  ? 294 MET A CG   1 
ATOM   4107 S SD   . MET B 1 294 ? 136.431 99.254  107.907 1.00 90.31  ? 294 MET A SD   1 
ATOM   4108 C CE   . MET B 1 294 ? 137.022 100.739 108.713 1.00 77.72  ? 294 MET A CE   1 
ATOM   4109 N N    . ASP B 1 295 ? 138.857 98.386  103.588 1.00 88.60  ? 295 ASP A N    1 
ATOM   4110 C CA   . ASP B 1 295 ? 138.221 97.527  102.591 1.00 89.77  ? 295 ASP A CA   1 
ATOM   4111 C C    . ASP B 1 295 ? 138.095 96.097  103.111 1.00 90.39  ? 295 ASP A C    1 
ATOM   4112 O O    . ASP B 1 295 ? 138.909 95.234  102.782 1.00 91.66  ? 295 ASP A O    1 
ATOM   4113 C CB   . ASP B 1 295 ? 139.009 97.539  101.282 1.00 87.29  ? 295 ASP A CB   1 
ATOM   4114 C CG   . ASP B 1 295 ? 138.573 98.651  100.348 1.00 88.11  ? 295 ASP A CG   1 
ATOM   4115 O OD1  . ASP B 1 295 ? 137.493 99.234  100.578 1.00 85.39  ? 295 ASP A OD1  1 
ATOM   4116 O OD2  . ASP B 1 295 ? 139.309 98.939  99.381  1.00 90.23  ? 295 ASP A OD2  1 
HETATM 4117 C C1   . D12 C 2 .   ? 124.259 100.236 132.352 1.00 20.00  ? 401 D12 U C1   1 
HETATM 4118 C C2   . D12 C 2 .   ? 124.954 100.960 131.225 1.00 20.00  ? 401 D12 U C2   1 
HETATM 4119 C C3   . D12 C 2 .   ? 126.445 100.825 131.452 1.00 20.00  ? 401 D12 U C3   1 
HETATM 4120 C C4   . D12 C 2 .   ? 127.300 101.887 130.813 1.00 20.00  ? 401 D12 U C4   1 
HETATM 4121 C C5   . D12 C 2 .   ? 127.715 101.601 129.384 1.00 20.00  ? 401 D12 U C5   1 
HETATM 4122 C C6   . D12 C 2 .   ? 126.571 101.069 128.572 1.00 20.00  ? 401 D12 U C6   1 
HETATM 4123 C C7   . D12 C 2 .   ? 126.815 100.963 127.106 1.00 20.00  ? 401 D12 U C7   1 
HETATM 4124 C C8   . D12 C 2 .   ? 125.538 100.341 126.615 1.00 20.00  ? 401 D12 U C8   1 
HETATM 4125 C C9   . D12 C 2 .   ? 124.839 101.252 125.645 1.00 20.00  ? 401 D12 U C9   1 
HETATM 4126 C C10  . D12 C 2 .   ? 125.573 101.374 124.327 1.00 20.00  ? 401 D12 U C10  1 
HETATM 4127 C C11  . D12 C 2 .   ? 125.832 100.059 123.648 1.00 20.00  ? 401 D12 U C11  1 
HETATM 4128 C C12  . D12 C 2 .   ? 125.789 100.236 122.152 1.00 20.00  ? 401 D12 U C12  1 
HETATM 4129 H H11  . D12 C 2 .   ? 124.750 99.281  132.513 1.00 20.00  ? 401 D12 U H11  1 
HETATM 4130 H H12  . D12 C 2 .   ? 123.218 100.075 132.089 1.00 20.00  ? 401 D12 U H12  1 
HETATM 4131 H H13  . D12 C 2 .   ? 124.322 100.835 133.255 1.00 20.00  ? 401 D12 U H13  1 
HETATM 4132 H H21  . D12 C 2 .   ? 124.674 102.007 131.224 1.00 20.00  ? 401 D12 U H21  1 
HETATM 4133 H H22  . D12 C 2 .   ? 124.654 100.493 130.297 1.00 20.00  ? 401 D12 U H22  1 
HETATM 4134 H H31  . D12 C 2 .   ? 126.763 99.853  131.090 1.00 20.00  ? 401 D12 U H31  1 
HETATM 4135 H H32  . D12 C 2 .   ? 126.615 100.856 132.521 1.00 20.00  ? 401 D12 U H32  1 
HETATM 4136 H H41  . D12 C 2 .   ? 128.196 102.012 131.411 1.00 20.00  ? 401 D12 U H41  1 
HETATM 4137 H H42  . D12 C 2 .   ? 126.743 102.818 130.821 1.00 20.00  ? 401 D12 U H42  1 
HETATM 4138 H H51  . D12 C 2 .   ? 128.071 102.515 128.926 1.00 20.00  ? 401 D12 U H51  1 
HETATM 4139 H H52  . D12 C 2 .   ? 128.511 100.865 129.389 1.00 20.00  ? 401 D12 U H52  1 
HETATM 4140 H H61  . D12 C 2 .   ? 126.339 100.067 128.911 1.00 20.00  ? 401 D12 U H61  1 
HETATM 4141 H H62  . D12 C 2 .   ? 125.716 101.718 128.714 1.00 20.00  ? 401 D12 U H62  1 
HETATM 4142 H H71  . D12 C 2 .   ? 126.964 101.951 126.685 1.00 20.00  ? 401 D12 U H71  1 
HETATM 4143 H H72  . D12 C 2 .   ? 127.663 100.320 126.904 1.00 20.00  ? 401 D12 U H72  1 
HETATM 4144 H H81  . D12 C 2 .   ? 124.871 100.190 127.457 1.00 20.00  ? 401 D12 U H81  1 
HETATM 4145 H H82  . D12 C 2 .   ? 125.752 99.375  126.177 1.00 20.00  ? 401 D12 U H82  1 
HETATM 4146 H H91  . D12 C 2 .   ? 124.758 102.235 126.094 1.00 20.00  ? 401 D12 U H91  1 
HETATM 4147 H H92  . D12 C 2 .   ? 123.846 100.863 125.455 1.00 20.00  ? 401 D12 U H92  1 
HETATM 4148 H H101 . D12 C 2 .   ? 124.972 101.979 123.659 1.00 20.00  ? 401 D12 U H101 1 
HETATM 4149 H H102 . D12 C 2 .   ? 126.521 101.876 124.484 1.00 20.00  ? 401 D12 U H102 1 
HETATM 4150 H H111 . D12 C 2 .   ? 125.070 99.348  123.943 1.00 20.00  ? 401 D12 U H111 1 
HETATM 4151 H H112 . D12 C 2 .   ? 126.807 99.688  123.943 1.00 20.00  ? 401 D12 U H112 1 
HETATM 4152 H H121 . D12 C 2 .   ? 126.336 101.137 121.887 1.00 20.00  ? 401 D12 U H121 1 
HETATM 4153 H H122 . D12 C 2 .   ? 126.242 99.375  121.672 1.00 20.00  ? 401 D12 U H122 1 
HETATM 4154 H H123 . D12 C 2 .   ? 124.757 100.332 121.835 1.00 20.00  ? 401 D12 U H123 1 
HETATM 4155 C C1   . D10 D 3 .   ? 110.625 99.159  135.562 1.00 20.00  ? 402 D10 U C1   1 
HETATM 4156 C C2   . D10 D 3 .   ? 110.876 99.905  134.263 1.00 20.00  ? 402 D10 U C2   1 
HETATM 4157 C C3   . D10 D 3 .   ? 112.134 99.410  133.567 1.00 20.00  ? 402 D10 U C3   1 
HETATM 4158 C C4   . D10 D 3 .   ? 112.253 99.988  132.174 1.00 20.00  ? 402 D10 U C4   1 
HETATM 4159 C C5   . D10 D 3 .   ? 111.521 99.155  131.149 1.00 20.00  ? 402 D10 U C5   1 
HETATM 4160 C C6   . D10 D 3 .   ? 111.720 99.744  129.768 1.00 20.00  ? 402 D10 U C6   1 
HETATM 4161 C C7   . D10 D 3 .   ? 112.710 98.924  128.954 1.00 20.00  ? 402 D10 U C7   1 
HETATM 4162 C C8   . D10 D 3 .   ? 112.403 98.957  127.472 1.00 20.00  ? 402 D10 U C8   1 
HETATM 4163 C C9   . D10 D 3 .   ? 112.579 100.351 126.912 1.00 20.00  ? 402 D10 U C9   1 
HETATM 4164 C C10  . D10 D 3 .   ? 112.879 100.334 125.425 1.00 20.00  ? 402 D10 U C10  1 
HETATM 4165 H H11  . D10 D 3 .   ? 110.475 98.109  135.341 1.00 20.00  ? 402 D10 U H11  1 
HETATM 4166 H H12  . D10 D 3 .   ? 111.484 99.274  136.208 1.00 20.00  ? 402 D10 U H12  1 
HETATM 4167 H H13  . D10 D 3 .   ? 109.745 99.562  136.045 1.00 20.00  ? 402 D10 U H13  1 
HETATM 4168 H H21  . D10 D 3 .   ? 110.988 100.959 134.477 1.00 20.00  ? 402 D10 U H21  1 
HETATM 4169 H H22  . D10 D 3 .   ? 110.031 99.762  133.605 1.00 20.00  ? 402 D10 U H22  1 
HETATM 4170 H H31  . D10 D 3 .   ? 112.091 98.331  133.495 1.00 20.00  ? 402 D10 U H31  1 
HETATM 4171 H H32  . D10 D 3 .   ? 112.997 99.699  134.149 1.00 20.00  ? 402 D10 U H32  1 
HETATM 4172 H H41  . D10 D 3 .   ? 113.296 100.041 131.897 1.00 20.00  ? 402 D10 U H41  1 
HETATM 4173 H H42  . D10 D 3 .   ? 111.831 100.983 132.175 1.00 20.00  ? 402 D10 U H42  1 
HETATM 4174 H H51  . D10 D 3 .   ? 111.898 98.143  131.184 1.00 20.00  ? 402 D10 U H51  1 
HETATM 4175 H H52  . D10 D 3 .   ? 110.466 99.151  131.387 1.00 20.00  ? 402 D10 U H52  1 
HETATM 4176 H H61  . D10 D 3 .   ? 110.771 99.768  129.248 1.00 20.00  ? 402 D10 U H61  1 
HETATM 4177 H H62  . D10 D 3 .   ? 112.099 100.753 129.869 1.00 20.00  ? 402 D10 U H62  1 
HETATM 4178 H H71  . D10 D 3 .   ? 113.703 99.320  129.115 1.00 20.00  ? 402 D10 U H71  1 
HETATM 4179 H H72  . D10 D 3 .   ? 112.681 97.895  129.284 1.00 20.00  ? 402 D10 U H72  1 
HETATM 4180 H H81  . D10 D 3 .   ? 111.381 98.639  127.316 1.00 20.00  ? 402 D10 U H81  1 
HETATM 4181 H H82  . D10 D 3 .   ? 113.073 98.283  126.955 1.00 20.00  ? 402 D10 U H82  1 
HETATM 4182 H H91  . D10 D 3 .   ? 113.394 100.834 127.431 1.00 20.00  ? 402 D10 U H91  1 
HETATM 4183 H H92  . D10 D 3 .   ? 111.669 100.913 127.079 1.00 20.00  ? 402 D10 U H92  1 
HETATM 4184 H H101 . D10 D 3 .   ? 112.070 99.835  124.906 1.00 20.00  ? 402 D10 U H101 1 
HETATM 4185 H H102 . D10 D 3 .   ? 113.803 99.798  125.257 1.00 20.00  ? 402 D10 U H102 1 
HETATM 4186 H H103 . D10 D 3 .   ? 112.975 101.351 125.064 1.00 20.00  ? 402 D10 U H103 1 
HETATM 4187 C C1   . OCT E 4 .   ? 129.462 97.342  134.744 1.00 20.00  ? 403 OCT U C1   1 
HETATM 4188 C C2   . OCT E 4 .   ? 129.463 97.076  133.253 1.00 20.00  ? 403 OCT U C2   1 
HETATM 4189 C C3   . OCT E 4 .   ? 130.635 97.779  132.607 1.00 20.00  ? 403 OCT U C3   1 
HETATM 4190 C C4   . OCT E 4 .   ? 130.309 98.239  131.202 1.00 20.00  ? 403 OCT U C4   1 
HETATM 4191 C C5   . OCT E 4 .   ? 130.121 97.073  130.251 1.00 20.00  ? 403 OCT U C5   1 
HETATM 4192 C C6   . OCT E 4 .   ? 130.534 97.465  128.850 1.00 20.00  ? 403 OCT U C6   1 
HETATM 4193 C C7   . OCT E 4 .   ? 130.164 96.375  127.862 1.00 20.00  ? 403 OCT U C7   1 
HETATM 4194 C C8   . OCT E 4 .   ? 130.261 96.862  126.427 1.00 20.00  ? 403 OCT U C8   1 
HETATM 4195 H H11  . OCT E 4 .   ? 128.754 96.681  135.228 1.00 20.00  ? 403 OCT U H11  1 
HETATM 4196 H H12  . OCT E 4 .   ? 130.456 97.164  135.133 1.00 20.00  ? 403 OCT U H12  1 
HETATM 4197 H H13  . OCT E 4 .   ? 129.182 98.371  134.920 1.00 20.00  ? 403 OCT U H13  1 
HETATM 4198 H H21  . OCT E 4 .   ? 128.543 97.448  132.821 1.00 20.00  ? 403 OCT U H21  1 
HETATM 4199 H H22  . OCT E 4 .   ? 129.541 96.012  133.075 1.00 20.00  ? 403 OCT U H22  1 
HETATM 4200 H H31  . OCT E 4 .   ? 130.896 98.637  133.209 1.00 20.00  ? 403 OCT U H31  1 
HETATM 4201 H H32  . OCT E 4 .   ? 131.474 97.099  132.568 1.00 20.00  ? 403 OCT U H32  1 
HETATM 4202 H H41  . OCT E 4 .   ? 129.396 98.820  131.226 1.00 20.00  ? 403 OCT U H41  1 
HETATM 4203 H H42  . OCT E 4 .   ? 131.117 98.856  130.836 1.00 20.00  ? 403 OCT U H42  1 
HETATM 4204 H H51  . OCT E 4 .   ? 129.079 96.780  130.245 1.00 20.00  ? 403 OCT U H51  1 
HETATM 4205 H H52  . OCT E 4 .   ? 130.727 96.241  130.581 1.00 20.00  ? 403 OCT U H52  1 
HETATM 4206 H H61  . OCT E 4 .   ? 130.030 98.381  128.574 1.00 20.00  ? 403 OCT U H61  1 
HETATM 4207 H H62  . OCT E 4 .   ? 131.606 97.619  128.826 1.00 20.00  ? 403 OCT U H62  1 
HETATM 4208 H H71  . OCT E 4 .   ? 130.836 95.536  127.998 1.00 20.00  ? 403 OCT U H71  1 
HETATM 4209 H H72  . OCT E 4 .   ? 129.150 96.056  128.060 1.00 20.00  ? 403 OCT U H72  1 
HETATM 4210 H H81  . OCT E 4 .   ? 130.140 96.024  125.753 1.00 20.00  ? 403 OCT U H81  1 
HETATM 4211 H H82  . OCT E 4 .   ? 129.484 97.593  126.249 1.00 20.00  ? 403 OCT U H82  1 
HETATM 4212 H H83  . OCT E 4 .   ? 131.231 97.320  126.275 1.00 20.00  ? 403 OCT U H83  1 
HETATM 4213 C C1   . OCT F 4 .   ? 122.455 94.617  133.302 1.00 20.00  ? 404 OCT U C1   1 
HETATM 4214 C C2   . OCT F 4 .   ? 121.639 94.505  132.028 1.00 20.00  ? 404 OCT U C2   1 
HETATM 4215 C C3   . OCT F 4 .   ? 122.296 95.250  130.888 1.00 20.00  ? 404 OCT U C3   1 
HETATM 4216 C C4   . OCT F 4 .   ? 121.226 95.796  129.973 1.00 20.00  ? 404 OCT U C4   1 
HETATM 4217 C C5   . OCT F 4 .   ? 121.844 96.256  128.673 1.00 20.00  ? 404 OCT U C5   1 
HETATM 4218 C C6   . OCT F 4 .   ? 121.283 95.517  127.477 1.00 20.00  ? 404 OCT U C6   1 
HETATM 4219 C C7   . OCT F 4 .   ? 122.321 95.432  126.376 1.00 20.00  ? 404 OCT U C7   1 
HETATM 4220 C C8   . OCT F 4 .   ? 121.749 95.899  125.053 1.00 20.00  ? 404 OCT U C8   1 
HETATM 4221 H H11  . OCT F 4 .   ? 122.255 95.572  133.769 1.00 20.00  ? 404 OCT U H11  1 
HETATM 4222 H H12  . OCT F 4 .   ? 122.182 93.815  133.977 1.00 20.00  ? 404 OCT U H12  1 
HETATM 4223 H H13  . OCT F 4 .   ? 123.507 94.547  133.055 1.00 20.00  ? 404 OCT U H13  1 
HETATM 4224 H H21  . OCT F 4 .   ? 120.656 94.927  132.195 1.00 20.00  ? 404 OCT U H21  1 
HETATM 4225 H H22  . OCT F 4 .   ? 121.539 93.463  131.758 1.00 20.00  ? 404 OCT U H22  1 
HETATM 4226 H H31  . OCT F 4 .   ? 122.886 96.065  131.282 1.00 20.00  ? 404 OCT U H31  1 
HETATM 4227 H H32  . OCT F 4 .   ? 122.931 94.571  130.334 1.00 20.00  ? 404 OCT U H32  1 
HETATM 4228 H H41  . OCT F 4 .   ? 120.496 95.021  129.781 1.00 20.00  ? 404 OCT U H41  1 
HETATM 4229 H H42  . OCT F 4 .   ? 120.741 96.632  130.459 1.00 20.00  ? 404 OCT U H42  1 
HETATM 4230 H H51  . OCT F 4 .   ? 122.910 96.086  128.726 1.00 20.00  ? 404 OCT U H51  1 
HETATM 4231 H H52  . OCT F 4 .   ? 121.660 97.313  128.547 1.00 20.00  ? 404 OCT U H52  1 
HETATM 4232 H H61  . OCT F 4 .   ? 121.001 94.515  127.774 1.00 20.00  ? 404 OCT U H61  1 
HETATM 4233 H H62  . OCT F 4 .   ? 120.414 96.043  127.106 1.00 20.00  ? 404 OCT U H62  1 
HETATM 4234 H H71  . OCT F 4 .   ? 123.165 96.061  126.629 1.00 20.00  ? 404 OCT U H71  1 
HETATM 4235 H H72  . OCT F 4 .   ? 122.653 94.407  126.278 1.00 20.00  ? 404 OCT U H72  1 
HETATM 4236 H H81  . OCT F 4 .   ? 120.858 95.326  124.832 1.00 20.00  ? 404 OCT U H81  1 
HETATM 4237 H H82  . OCT F 4 .   ? 121.495 96.948  125.128 1.00 20.00  ? 404 OCT U H82  1 
HETATM 4238 H H83  . OCT F 4 .   ? 122.482 95.753  124.271 1.00 20.00  ? 404 OCT U H83  1 
HETATM 4239 C C1   . D10 G 3 .   ? 105.591 101.113 135.065 1.00 20.00  ? 405 D10 U C1   1 
HETATM 4240 C C2   . D10 G 3 .   ? 106.350 102.354 134.625 1.00 20.00  ? 405 D10 U C2   1 
HETATM 4241 C C3   . D10 G 3 .   ? 106.805 102.259 133.183 1.00 20.00  ? 405 D10 U C3   1 
HETATM 4242 C C4   . D10 G 3 .   ? 105.697 102.489 132.182 1.00 20.00  ? 405 D10 U C4   1 
HETATM 4243 C C5   . D10 G 3 .   ? 106.212 102.123 130.816 1.00 20.00  ? 405 D10 U C5   1 
HETATM 4244 C C6   . D10 G 3 .   ? 105.937 103.210 129.805 1.00 20.00  ? 405 D10 U C6   1 
HETATM 4245 C C7   . D10 G 3 .   ? 106.800 103.042 128.571 1.00 20.00  ? 405 D10 U C7   1 
HETATM 4246 C C8   . D10 G 3 .   ? 106.274 101.920 127.709 1.00 20.00  ? 405 D10 U C8   1 
HETATM 4247 C C9   . D10 G 3 .   ? 105.879 102.396 126.332 1.00 20.00  ? 405 D10 U C9   1 
HETATM 4248 C C10  . D10 G 3 .   ? 107.042 102.269 125.363 1.00 20.00  ? 405 D10 U C10  1 
HETATM 4249 H H11  . D10 G 3 .   ? 104.563 101.191 134.739 1.00 20.00  ? 405 D10 U H11  1 
HETATM 4250 H H12  . D10 G 3 .   ? 106.048 100.240 134.616 1.00 20.00  ? 405 D10 U H12  1 
HETATM 4251 H H13  . D10 G 3 .   ? 105.629 101.033 136.144 1.00 20.00  ? 405 D10 U H13  1 
HETATM 4252 H H21  . D10 G 3 .   ? 107.214 102.484 135.259 1.00 20.00  ? 405 D10 U H21  1 
HETATM 4253 H H22  . D10 G 3 .   ? 105.699 103.213 134.722 1.00 20.00  ? 405 D10 U H22  1 
HETATM 4254 H H31  . D10 G 3 .   ? 107.214 101.271 133.015 1.00 20.00  ? 405 D10 U H31  1 
HETATM 4255 H H32  . D10 G 3 .   ? 107.578 102.993 133.011 1.00 20.00  ? 405 D10 U H32  1 
HETATM 4256 H H41  . D10 G 3 .   ? 105.406 103.530 132.198 1.00 20.00  ? 405 D10 U H41  1 
HETATM 4257 H H42  . D10 G 3 .   ? 104.845 101.867 132.425 1.00 20.00  ? 405 D10 U H42  1 
HETATM 4258 H H51  . D10 G 3 .   ? 107.280 101.963 130.875 1.00 20.00  ? 405 D10 U H51  1 
HETATM 4259 H H52  . D10 G 3 .   ? 105.733 101.208 130.491 1.00 20.00  ? 405 D10 U H52  1 
HETATM 4260 H H61  . D10 G 3 .   ? 104.895 103.173 129.518 1.00 20.00  ? 405 D10 U H61  1 
HETATM 4261 H H62  . D10 G 3 .   ? 106.153 104.170 130.254 1.00 20.00  ? 405 D10 U H62  1 
HETATM 4262 H H71  . D10 G 3 .   ? 106.805 103.965 128.009 1.00 20.00  ? 405 D10 U H71  1 
HETATM 4263 H H72  . D10 G 3 .   ? 107.810 102.807 128.880 1.00 20.00  ? 405 D10 U H72  1 
HETATM 4264 H H81  . D10 G 3 .   ? 105.409 101.479 128.184 1.00 20.00  ? 405 D10 U H81  1 
HETATM 4265 H H82  . D10 G 3 .   ? 107.045 101.167 127.608 1.00 20.00  ? 405 D10 U H82  1 
HETATM 4266 H H91  . D10 G 3 .   ? 105.566 103.429 126.383 1.00 20.00  ? 405 D10 U H91  1 
HETATM 4267 H H92  . D10 G 3 .   ? 105.058 101.790 125.975 1.00 20.00  ? 405 D10 U H92  1 
HETATM 4268 H H101 . D10 G 3 .   ? 107.281 101.222 125.231 1.00 20.00  ? 405 D10 U H101 1 
HETATM 4269 H H102 . D10 G 3 .   ? 107.900 102.787 125.772 1.00 20.00  ? 405 D10 U H102 1 
HETATM 4270 H H103 . D10 G 3 .   ? 106.767 102.706 124.412 1.00 20.00  ? 405 D10 U H103 1 
HETATM 4271 C C1   . EIC H 5 .   ? 123.061 106.363 133.539 1.00 20.00  ? 406 EIC U C1   1 
HETATM 4272 C C2   . EIC H 5 .   ? 123.271 106.658 132.058 1.00 20.00  ? 406 EIC U C2   1 
HETATM 4273 C C3   . EIC H 5 .   ? 122.683 108.007 131.611 1.00 20.00  ? 406 EIC U C3   1 
HETATM 4274 C C4   . EIC H 5 .   ? 123.504 108.640 130.482 1.00 20.00  ? 406 EIC U C4   1 
HETATM 4275 C C5   . EIC H 5 .   ? 122.679 109.708 129.756 1.00 20.00  ? 406 EIC U C5   1 
HETATM 4276 C C6   . EIC H 5 .   ? 123.539 110.905 129.337 1.00 20.00  ? 406 EIC U C6   1 
HETATM 4277 C C7   . EIC H 5 .   ? 122.985 111.581 128.077 1.00 20.00  ? 406 EIC U C7   1 
HETATM 4278 C C8   . EIC H 5 .   ? 123.513 110.904 126.810 1.00 20.00  ? 406 EIC U C8   1 
HETATM 4279 C C9   . EIC H 5 .   ? 123.238 111.770 125.607 1.00 20.00  ? 406 EIC U C9   1 
HETATM 4280 C C10  . EIC H 5 .   ? 123.948 111.838 124.483 1.00 20.00  ? 406 EIC U C10  1 
HETATM 4281 C C11  . EIC H 5 .   ? 125.199 111.072 124.127 1.00 20.00  ? 406 EIC U C11  1 
HETATM 4282 C C12  . EIC H 5 .   ? 125.589 111.427 122.710 1.00 20.00  ? 406 EIC U C12  1 
HETATM 4283 C C13  . EIC H 5 .   ? 125.738 110.620 121.655 1.00 20.00  ? 406 EIC U C13  1 
HETATM 4284 C C14  . EIC H 5 .   ? 125.565 109.121 121.613 1.00 20.00  ? 406 EIC U C14  1 
HETATM 4285 C C15  . EIC H 5 .   ? 125.785 108.580 120.194 1.00 20.00  ? 406 EIC U C15  1 
HETATM 4286 C C16  . EIC H 5 .   ? 126.020 107.062 120.216 1.00 20.00  ? 406 EIC U C16  1 
HETATM 4287 C C17  . EIC H 5 .   ? 124.878 106.302 119.533 1.00 20.00  ? 406 EIC U C17  1 
HETATM 4288 C C18  . EIC H 5 .   ? 124.735 104.878 120.083 1.00 20.00  ? 406 EIC U C18  1 
HETATM 4289 O O1   . EIC H 5 .   ? 123.970 105.877 134.179 1.00 20.00  ? 406 EIC U O1   1 
HETATM 4290 O O2   . EIC H 5 .   ? 121.980 106.635 133.996 1.00 20.00  ? 406 EIC U O2   1 
HETATM 4291 H H21  . EIC H 5 .   ? 122.813 105.846 131.482 1.00 20.00  ? 406 EIC U H21  1 
HETATM 4292 H H22  . EIC H 5 .   ? 124.348 106.642 131.855 1.00 20.00  ? 406 EIC U H22  1 
HETATM 4293 H H31  . EIC H 5 .   ? 122.649 108.692 132.467 1.00 20.00  ? 406 EIC U H31  1 
HETATM 4294 H H32  . EIC H 5 .   ? 121.648 107.858 131.275 1.00 20.00  ? 406 EIC U H32  1 
HETATM 4295 H H41  . EIC H 5 .   ? 123.819 107.859 129.779 1.00 20.00  ? 406 EIC U H41  1 
HETATM 4296 H H42  . EIC H 5 .   ? 124.413 109.092 130.901 1.00 20.00  ? 406 EIC U H42  1 
HETATM 4297 H H51  . EIC H 5 .   ? 121.872 110.043 130.417 1.00 20.00  ? 406 EIC U H51  1 
HETATM 4298 H H52  . EIC H 5 .   ? 122.207 109.267 128.869 1.00 20.00  ? 406 EIC U H52  1 
HETATM 4299 H H61  . EIC H 5 .   ? 124.568 110.564 129.152 1.00 20.00  ? 406 EIC U H61  1 
HETATM 4300 H H62  . EIC H 5 .   ? 123.576 111.633 130.160 1.00 20.00  ? 406 EIC U H62  1 
HETATM 4301 H H71  . EIC H 5 .   ? 123.273 112.641 128.076 1.00 20.00  ? 406 EIC U H71  1 
HETATM 4302 H H72  . EIC H 5 .   ? 121.889 111.529 128.085 1.00 20.00  ? 406 EIC U H72  1 
HETATM 4303 H H81  . EIC H 5 .   ? 123.015 109.937 126.686 1.00 20.00  ? 406 EIC U H81  1 
HETATM 4304 H H82  . EIC H 5 .   ? 124.579 110.693 126.934 1.00 20.00  ? 406 EIC U H82  1 
HETATM 4305 H H91  . EIC H 5 .   ? 122.352 112.394 125.708 1.00 20.00  ? 406 EIC U H91  1 
HETATM 4306 H H1O1 . EIC H 5 .   ? 123.620 112.517 123.696 1.00 20.00  ? 406 EIC U H1O1 1 
HETATM 4307 H H111 . EIC H 5 .   ? 125.051 109.990 124.203 1.00 20.00  ? 406 EIC U H111 1 
HETATM 4308 H H112 . EIC H 5 .   ? 125.982 111.338 124.845 1.00 20.00  ? 406 EIC U H112 1 
HETATM 4309 H H121 . EIC H 5 .   ? 125.752 112.495 122.569 1.00 20.00  ? 406 EIC U H121 1 
HETATM 4310 H H131 . EIC H 5 .   ? 126.024 111.056 120.700 1.00 20.00  ? 406 EIC U H131 1 
HETATM 4311 H H141 . EIC H 5 .   ? 124.575 108.812 121.965 1.00 20.00  ? 406 EIC U H141 1 
HETATM 4312 H H142 . EIC H 5 .   ? 126.294 108.658 122.290 1.00 20.00  ? 406 EIC U H142 1 
HETATM 4313 H H151 . EIC H 5 .   ? 126.648 109.086 119.745 1.00 20.00  ? 406 EIC U H151 1 
HETATM 4314 H H152 . EIC H 5 .   ? 124.907 108.805 119.575 1.00 20.00  ? 406 EIC U H152 1 
HETATM 4315 H H161 . EIC H 5 .   ? 126.102 106.722 121.258 1.00 20.00  ? 406 EIC U H161 1 
HETATM 4316 H H162 . EIC H 5 .   ? 126.972 106.824 119.718 1.00 20.00  ? 406 EIC U H162 1 
HETATM 4317 H H171 . EIC H 5 .   ? 125.057 106.259 118.452 1.00 20.00  ? 406 EIC U H171 1 
HETATM 4318 H H172 . EIC H 5 .   ? 123.935 106.837 119.687 1.00 20.00  ? 406 EIC U H172 1 
HETATM 4319 H H181 . EIC H 5 .   ? 124.053 104.870 120.941 1.00 20.00  ? 406 EIC U H181 1 
HETATM 4320 H H182 . EIC H 5 .   ? 124.341 104.197 119.318 1.00 20.00  ? 406 EIC U H182 1 
HETATM 4321 H H183 . EIC H 5 .   ? 125.707 104.493 120.420 1.00 20.00  ? 406 EIC U H183 1 
HETATM 4322 C C1   . OCT I 4 .   ? 125.891 144.733 116.091 1.00 20.00  ? 407 OCT U C1   1 
HETATM 4323 C C2   . OCT I 4 .   ? 125.706 145.507 114.793 1.00 20.00  ? 407 OCT U C2   1 
HETATM 4324 C C3   . OCT I 4 .   ? 126.746 146.605 114.692 1.00 20.00  ? 407 OCT U C3   1 
HETATM 4325 C C4   . OCT I 4 .   ? 126.369 147.714 113.727 1.00 20.00  ? 407 OCT U C4   1 
HETATM 4326 C C5   . OCT I 4 .   ? 126.887 147.477 112.321 1.00 20.00  ? 407 OCT U C5   1 
HETATM 4327 C C6   . OCT I 4 .   ? 125.850 147.853 111.281 1.00 20.00  ? 407 OCT U C6   1 
HETATM 4328 C C7   . OCT I 4 .   ? 126.464 148.038 109.906 1.00 20.00  ? 407 OCT U C7   1 
HETATM 4329 C C8   . OCT I 4 .   ? 126.786 149.487 109.603 1.00 20.00  ? 407 OCT U C8   1 
HETATM 4330 H H11  . OCT I 4 .   ? 125.347 143.799 116.035 1.00 20.00  ? 407 OCT U H11  1 
HETATM 4331 H H12  . OCT I 4 .   ? 126.946 144.537 116.234 1.00 20.00  ? 407 OCT U H12  1 
HETATM 4332 H H13  . OCT I 4 .   ? 125.517 145.328 116.913 1.00 20.00  ? 407 OCT U H13  1 
HETATM 4333 H H21  . OCT I 4 .   ? 124.717 145.947 114.775 1.00 20.00  ? 407 OCT U H21  1 
HETATM 4334 H H22  . OCT I 4 .   ? 125.818 144.834 113.952 1.00 20.00  ? 407 OCT U H22  1 
HETATM 4335 H H31  . OCT I 4 .   ? 126.887 147.030 115.675 1.00 20.00  ? 407 OCT U H31  1 
HETATM 4336 H H32  . OCT I 4 .   ? 127.681 146.165 114.363 1.00 20.00  ? 407 OCT U H32  1 
HETATM 4337 H H41  . OCT I 4 .   ? 125.291 147.784 113.684 1.00 20.00  ? 407 OCT U H41  1 
HETATM 4338 H H42  . OCT I 4 .   ? 126.772 148.649 114.093 1.00 20.00  ? 407 OCT U H42  1 
HETATM 4339 H H51  . OCT I 4 .   ? 127.133 146.430 112.207 1.00 20.00  ? 407 OCT U H51  1 
HETATM 4340 H H52  . OCT I 4 .   ? 127.775 148.074 112.162 1.00 20.00  ? 407 OCT U H52  1 
HETATM 4341 H H61  . OCT I 4 .   ? 125.102 147.074 111.238 1.00 20.00  ? 407 OCT U H61  1 
HETATM 4342 H H62  . OCT I 4 .   ? 125.382 148.782 111.578 1.00 20.00  ? 407 OCT U H62  1 
HETATM 4343 H H71  . OCT I 4 .   ? 127.377 147.463 109.863 1.00 20.00  ? 407 OCT U H71  1 
HETATM 4344 H H72  . OCT I 4 .   ? 125.773 147.670 109.160 1.00 20.00  ? 407 OCT U H72  1 
HETATM 4345 H H81  . OCT I 4 .   ? 127.321 149.909 110.445 1.00 20.00  ? 407 OCT U H81  1 
HETATM 4346 H H82  . OCT I 4 .   ? 127.399 149.542 108.714 1.00 20.00  ? 407 OCT U H82  1 
HETATM 4347 H H83  . OCT I 4 .   ? 125.864 150.031 109.451 1.00 20.00  ? 407 OCT U H83  1 
HETATM 4348 C C1   . OCT J 4 .   ? 115.708 105.248 115.044 1.00 20.00  ? 401 OCT A C1   1 
HETATM 4349 C C2   . OCT J 4 .   ? 115.747 105.683 113.593 1.00 20.00  ? 401 OCT A C2   1 
HETATM 4350 C C3   . OCT J 4 .   ? 116.530 104.680 112.780 1.00 20.00  ? 401 OCT A C3   1 
HETATM 4351 C C4   . OCT J 4 .   ? 116.625 105.094 111.326 1.00 20.00  ? 401 OCT A C4   1 
HETATM 4352 C C5   . OCT J 4 .   ? 117.440 104.046 110.603 1.00 20.00  ? 401 OCT A C5   1 
HETATM 4353 C C6   . OCT J 4 .   ? 117.459 104.248 109.111 1.00 20.00  ? 401 OCT A C6   1 
HETATM 4354 C C7   . OCT J 4 .   ? 117.841 102.941 108.432 1.00 20.00  ? 401 OCT A C7   1 
HETATM 4355 C C8   . OCT J 4 .   ? 117.511 102.968 106.951 1.00 20.00  ? 401 OCT A C8   1 
HETATM 4356 H H11  . OCT J 4 .   ? 114.857 105.701 115.534 1.00 20.00  ? 401 OCT A H11  1 
HETATM 4357 H H12  . OCT J 4 .   ? 115.625 104.169 115.086 1.00 20.00  ? 401 OCT A H12  1 
HETATM 4358 H H13  . OCT J 4 .   ? 116.621 105.561 115.534 1.00 20.00  ? 401 OCT A H13  1 
HETATM 4359 H H21  . OCT J 4 .   ? 116.224 106.651 113.518 1.00 20.00  ? 401 OCT A H21  1 
HETATM 4360 H H22  . OCT J 4 .   ? 114.738 105.742 113.206 1.00 20.00  ? 401 OCT A H22  1 
HETATM 4361 H H31  . OCT J 4 .   ? 117.529 104.599 113.188 1.00 20.00  ? 401 OCT A H31  1 
HETATM 4362 H H32  . OCT J 4 .   ? 116.042 103.716 112.841 1.00 20.00  ? 401 OCT A H32  1 
HETATM 4363 H H41  . OCT J 4 .   ? 115.633 105.142 110.895 1.00 20.00  ? 401 OCT A H41  1 
HETATM 4364 H H42  . OCT J 4 .   ? 117.111 106.056 111.250 1.00 20.00  ? 401 OCT A H42  1 
HETATM 4365 H H51  . OCT J 4 .   ? 117.022 103.075 110.823 1.00 20.00  ? 401 OCT A H51  1 
HETATM 4366 H H52  . OCT J 4 .   ? 118.457 104.083 110.972 1.00 20.00  ? 401 OCT A H52  1 
HETATM 4367 H H61  . OCT J 4 .   ? 116.475 104.550 108.777 1.00 20.00  ? 401 OCT A H61  1 
HETATM 4368 H H62  . OCT J 4 .   ? 118.182 105.011 108.856 1.00 20.00  ? 401 OCT A H62  1 
HETATM 4369 H H71  . OCT J 4 .   ? 118.904 102.781 108.559 1.00 20.00  ? 401 OCT A H71  1 
HETATM 4370 H H72  . OCT J 4 .   ? 117.299 102.130 108.898 1.00 20.00  ? 401 OCT A H72  1 
HETATM 4371 H H81  . OCT J 4 .   ? 116.439 103.039 106.829 1.00 20.00  ? 401 OCT A H81  1 
HETATM 4372 H H82  . OCT J 4 .   ? 117.986 103.828 106.499 1.00 20.00  ? 401 OCT A H82  1 
HETATM 4373 H H83  . OCT J 4 .   ? 117.875 102.061 106.487 1.00 20.00  ? 401 OCT A H83  1 
HETATM 4374 C C1   . HEX K 6 .   ? 111.380 148.291 131.049 1.00 20.00  ? 402 HEX A C1   1 
HETATM 4375 C C2   . HEX K 6 .   ? 109.906 148.308 130.667 1.00 20.00  ? 402 HEX A C2   1 
HETATM 4376 C C3   . HEX K 6 .   ? 109.638 147.489 129.416 1.00 20.00  ? 402 HEX A C3   1 
HETATM 4377 C C4   . HEX K 6 .   ? 110.357 148.065 128.205 1.00 20.00  ? 402 HEX A C4   1 
HETATM 4378 C C5   . HEX K 6 .   ? 109.515 147.944 126.945 1.00 20.00  ? 402 HEX A C5   1 
HETATM 4379 C C6   . HEX K 6 .   ? 109.265 146.488 126.577 1.00 20.00  ? 402 HEX A C6   1 
HETATM 4380 H H11  . HEX K 6 .   ? 111.889 149.107 130.553 1.00 20.00  ? 402 HEX A H11  1 
HETATM 4381 H H12  . HEX K 6 .   ? 111.814 147.351 130.737 1.00 20.00  ? 402 HEX A H12  1 
HETATM 4382 H H13  . HEX K 6 .   ? 111.475 148.400 132.122 1.00 20.00  ? 402 HEX A H13  1 
HETATM 4383 H H21  . HEX K 6 .   ? 109.602 149.330 130.486 1.00 20.00  ? 402 HEX A H21  1 
HETATM 4384 H H22  . HEX K 6 .   ? 109.325 147.901 131.483 1.00 20.00  ? 402 HEX A H22  1 
HETATM 4385 H H31  . HEX K 6 .   ? 108.575 147.482 129.222 1.00 20.00  ? 402 HEX A H31  1 
HETATM 4386 H H32  . HEX K 6 .   ? 109.981 146.476 129.578 1.00 20.00  ? 402 HEX A H32  1 
HETATM 4387 H H41  . HEX K 6 .   ? 110.570 149.113 128.384 1.00 20.00  ? 402 HEX A H41  1 
HETATM 4388 H H42  . HEX K 6 .   ? 111.288 147.532 128.061 1.00 20.00  ? 402 HEX A H42  1 
HETATM 4389 H H51  . HEX K 6 .   ? 108.564 148.432 127.115 1.00 20.00  ? 402 HEX A H51  1 
HETATM 4390 H H52  . HEX K 6 .   ? 110.028 148.434 126.129 1.00 20.00  ? 402 HEX A H52  1 
HETATM 4391 H H61  . HEX K 6 .   ? 109.151 146.402 125.504 1.00 20.00  ? 402 HEX A H61  1 
HETATM 4392 H H62  . HEX K 6 .   ? 108.364 146.145 127.069 1.00 20.00  ? 402 HEX A H62  1 
HETATM 4393 H H63  . HEX K 6 .   ? 110.107 145.891 126.904 1.00 20.00  ? 402 HEX A H63  1 
HETATM 4394 C C1   . D12 L 2 .   ? 123.262 147.213 132.171 1.00 20.00  ? 403 D12 A C1   1 
HETATM 4395 C C2   . D12 L 2 .   ? 122.445 146.944 130.932 1.00 20.00  ? 403 D12 A C2   1 
HETATM 4396 C C3   . D12 L 2 .   ? 121.255 146.055 131.231 1.00 20.00  ? 403 D12 A C3   1 
HETATM 4397 C C4   . D12 L 2 .   ? 120.142 146.295 130.243 1.00 20.00  ? 403 D12 A C4   1 
HETATM 4398 C C5   . D12 L 2 .   ? 120.440 145.714 128.883 1.00 20.00  ? 403 D12 A C5   1 
HETATM 4399 C C6   . D12 L 2 .   ? 120.383 146.693 127.736 1.00 20.00  ? 403 D12 A C6   1 
HETATM 4400 C C7   . D12 L 2 .   ? 121.649 147.503 127.572 1.00 20.00  ? 403 D12 A C7   1 
HETATM 4401 C C8   . D12 L 2 .   ? 122.827 146.735 127.014 1.00 20.00  ? 403 D12 A C8   1 
HETATM 4402 C C9   . D12 L 2 .   ? 122.583 146.172 125.634 1.00 20.00  ? 403 D12 A C9   1 
HETATM 4403 C C10  . D12 L 2 .   ? 121.916 147.150 124.687 1.00 20.00  ? 403 D12 A C10  1 
HETATM 4404 C C11  . D12 L 2 .   ? 122.386 146.906 123.279 1.00 20.00  ? 403 D12 A C11  1 
HETATM 4405 C C12  . D12 L 2 .   ? 121.543 147.683 122.301 1.00 20.00  ? 403 D12 A C12  1 
HETATM 4406 H H11  . D12 L 2 .   ? 122.709 147.882 132.822 1.00 20.00  ? 403 D12 A H11  1 
HETATM 4407 H H12  . D12 L 2 .   ? 124.205 147.671 131.888 1.00 20.00  ? 403 D12 A H12  1 
HETATM 4408 H H13  . D12 L 2 .   ? 123.445 146.275 132.683 1.00 20.00  ? 403 D12 A H13  1 
HETATM 4409 H H21  . D12 L 2 .   ? 123.064 146.478 130.173 1.00 20.00  ? 403 D12 A H21  1 
HETATM 4410 H H22  . D12 L 2 .   ? 122.079 147.893 130.567 1.00 20.00  ? 403 D12 A H22  1 
HETATM 4411 H H31  . D12 L 2 .   ? 120.901 146.271 132.231 1.00 20.00  ? 403 D12 A H31  1 
HETATM 4412 H H32  . D12 L 2 .   ? 121.565 145.019 131.170 1.00 20.00  ? 403 D12 A H32  1 
HETATM 4413 H H41  . D12 L 2 .   ? 119.994 147.365 130.137 1.00 20.00  ? 403 D12 A H41  1 
HETATM 4414 H H42  . D12 L 2 .   ? 119.230 145.848 130.627 1.00 20.00  ? 403 D12 A H42  1 
HETATM 4415 H H51  . D12 L 2 .   ? 121.421 145.257 128.913 1.00 20.00  ? 403 D12 A H51  1 
HETATM 4416 H H52  . D12 L 2 .   ? 119.714 144.933 128.686 1.00 20.00  ? 403 D12 A H52  1 
HETATM 4417 H H61  . D12 L 2 .   ? 120.159 146.151 126.826 1.00 20.00  ? 403 D12 A H61  1 
HETATM 4418 H H62  . D12 L 2 .   ? 119.570 147.383 127.928 1.00 20.00  ? 403 D12 A H62  1 
HETATM 4419 H H71  . D12 L 2 .   ? 121.426 148.360 126.952 1.00 20.00  ? 403 D12 A H71  1 
HETATM 4420 H H72  . D12 L 2 .   ? 121.936 147.894 128.531 1.00 20.00  ? 403 D12 A H72  1 
HETATM 4421 H H81  . D12 L 2 .   ? 123.072 145.923 127.688 1.00 20.00  ? 403 D12 A H81  1 
HETATM 4422 H H82  . D12 L 2 .   ? 123.673 147.411 126.959 1.00 20.00  ? 403 D12 A H82  1 
HETATM 4423 H H91  . D12 L 2 .   ? 121.958 145.292 125.722 1.00 20.00  ? 403 D12 A H91  1 
HETATM 4424 H H92  . D12 L 2 .   ? 123.535 145.883 125.206 1.00 20.00  ? 403 D12 A H92  1 
HETATM 4425 H H101 . D12 L 2 .   ? 120.839 147.029 124.734 1.00 20.00  ? 403 D12 A H101 1 
HETATM 4426 H H102 . D12 L 2 .   ? 122.186 148.164 124.954 1.00 20.00  ? 403 D12 A H102 1 
HETATM 4427 H H111 . D12 L 2 .   ? 122.309 145.847 123.061 1.00 20.00  ? 403 D12 A H111 1 
HETATM 4428 H H112 . D12 L 2 .   ? 123.420 147.220 123.193 1.00 20.00  ? 403 D12 A H112 1 
HETATM 4429 H H121 . D12 L 2 .   ? 122.150 147.978 121.452 1.00 20.00  ? 403 D12 A H121 1 
HETATM 4430 H H122 . D12 L 2 .   ? 120.717 147.062 121.966 1.00 20.00  ? 403 D12 A H122 1 
HETATM 4431 H H123 . D12 L 2 .   ? 121.152 148.566 122.799 1.00 20.00  ? 403 D12 A H123 1 
HETATM 4432 C C1   . D10 M 3 .   ? 137.110 148.764 136.313 1.00 20.00  ? 404 D10 A C1   1 
HETATM 4433 C C2   . D10 M 3 .   ? 137.171 148.356 134.849 1.00 20.00  ? 404 D10 A C2   1 
HETATM 4434 C C3   . D10 M 3 .   ? 135.905 147.628 134.427 1.00 20.00  ? 404 D10 A C3   1 
HETATM 4435 C C4   . D10 M 3 .   ? 135.337 148.152 133.127 1.00 20.00  ? 404 D10 A C4   1 
HETATM 4436 C C5   . D10 M 3 .   ? 136.105 147.611 131.941 1.00 20.00  ? 404 D10 A C5   1 
HETATM 4437 C C6   . D10 M 3 .   ? 136.073 148.586 130.796 1.00 20.00  ? 404 D10 A C6   1 
HETATM 4438 C C7   . D10 M 3 .   ? 135.936 147.883 129.455 1.00 20.00  ? 404 D10 A C7   1 
HETATM 4439 C C8   . D10 M 3 .   ? 134.945 148.637 128.588 1.00 20.00  ? 404 D10 A C8   1 
HETATM 4440 C C9   . D10 M 3 .   ? 135.325 148.628 127.126 1.00 20.00  ? 404 D10 A C9   1 
HETATM 4441 C C10  . D10 M 3 .   ? 134.993 147.305 126.462 1.00 20.00  ? 404 D10 A C10  1 
HETATM 4442 H H11  . D10 M 3 .   ? 136.878 147.896 136.914 1.00 20.00  ? 404 D10 A H11  1 
HETATM 4443 H H12  . D10 M 3 .   ? 138.068 149.171 136.612 1.00 20.00  ? 404 D10 A H12  1 
HETATM 4444 H H13  . D10 M 3 .   ? 136.339 149.512 136.441 1.00 20.00  ? 404 D10 A H13  1 
HETATM 4445 H H21  . D10 M 3 .   ? 138.019 147.704 134.698 1.00 20.00  ? 404 D10 A H21  1 
HETATM 4446 H H22  . D10 M 3 .   ? 137.287 149.241 134.241 1.00 20.00  ? 404 D10 A H22  1 
HETATM 4447 H H31  . D10 M 3 .   ? 135.165 147.744 135.208 1.00 20.00  ? 404 D10 A H31  1 
HETATM 4448 H H32  . D10 M 3 .   ? 136.133 146.578 134.305 1.00 20.00  ? 404 D10 A H32  1 
HETATM 4449 H H41  . D10 M 3 .   ? 135.399 149.232 133.125 1.00 20.00  ? 404 D10 A H41  1 
HETATM 4450 H H42  . D10 M 3 .   ? 134.302 147.851 133.044 1.00 20.00  ? 404 D10 A H42  1 
HETATM 4451 H H51  . D10 M 3 .   ? 137.133 147.433 132.226 1.00 20.00  ? 404 D10 A H51  1 
HETATM 4452 H H52  . D10 M 3 .   ? 135.654 146.676 131.643 1.00 20.00  ? 404 D10 A H52  1 
HETATM 4453 H H61  . D10 M 3 .   ? 135.228 149.244 130.938 1.00 20.00  ? 404 D10 A H61  1 
HETATM 4454 H H62  . D10 M 3 .   ? 136.985 149.170 130.801 1.00 20.00  ? 404 D10 A H62  1 
HETATM 4455 H H71  . D10 M 3 .   ? 136.898 147.859 128.962 1.00 20.00  ? 404 D10 A H71  1 
HETATM 4456 H H72  . D10 M 3 .   ? 135.580 146.872 129.595 1.00 20.00  ? 404 D10 A H72  1 
HETATM 4457 H H81  . D10 M 3 .   ? 134.897 149.666 128.918 1.00 20.00  ? 404 D10 A H81  1 
HETATM 4458 H H82  . D10 M 3 .   ? 133.968 148.183 128.700 1.00 20.00  ? 404 D10 A H82  1 
HETATM 4459 H H91  . D10 M 3 .   ? 136.389 148.808 127.039 1.00 20.00  ? 404 D10 A H91  1 
HETATM 4460 H H92  . D10 M 3 .   ? 134.787 149.419 126.620 1.00 20.00  ? 404 D10 A H92  1 
HETATM 4461 H H101 . D10 M 3 .   ? 134.007 146.988 126.779 1.00 20.00  ? 404 D10 A H101 1 
HETATM 4462 H H102 . D10 M 3 .   ? 135.725 146.564 126.760 1.00 20.00  ? 404 D10 A H102 1 
HETATM 4463 H H103 . D10 M 3 .   ? 135.009 147.428 125.387 1.00 20.00  ? 404 D10 A H103 1 
HETATM 4464 C C1   . OCT N 4 .   ? 117.564 149.876 135.020 1.00 20.00  ? 405 OCT A C1   1 
HETATM 4465 C C2   . OCT N 4 .   ? 118.164 150.642 133.853 1.00 20.00  ? 405 OCT A C2   1 
HETATM 4466 C C3   . OCT N 4 .   ? 118.175 149.795 132.603 1.00 20.00  ? 405 OCT A C3   1 
HETATM 4467 C C4   . OCT N 4 .   ? 116.975 150.064 131.724 1.00 20.00  ? 405 OCT A C4   1 
HETATM 4468 C C5   . OCT N 4 .   ? 117.202 149.576 130.305 1.00 20.00  ? 405 OCT A C5   1 
HETATM 4469 C C6   . OCT N 4 .   ? 117.436 150.712 129.332 1.00 20.00  ? 405 OCT A C6   1 
HETATM 4470 C C7   . OCT N 4 .   ? 117.343 150.201 127.906 1.00 20.00  ? 405 OCT A C7   1 
HETATM 4471 C C8   . OCT N 4 .   ? 117.482 151.316 126.884 1.00 20.00  ? 405 OCT A C8   1 
HETATM 4472 H H11  . OCT N 4 .   ? 117.381 150.556 135.841 1.00 20.00  ? 405 OCT A H11  1 
HETATM 4473 H H12  . OCT N 4 .   ? 116.634 149.424 134.703 1.00 20.00  ? 405 OCT A H12  1 
HETATM 4474 H H13  . OCT N 4 .   ? 118.255 149.103 135.333 1.00 20.00  ? 405 OCT A H13  1 
HETATM 4475 H H21  . OCT N 4 .   ? 119.180 150.924 134.099 1.00 20.00  ? 405 OCT A H21  1 
HETATM 4476 H H22  . OCT N 4 .   ? 117.578 151.533 133.676 1.00 20.00  ? 405 OCT A H22  1 
HETATM 4477 H H31  . OCT N 4 .   ? 119.072 150.009 132.036 1.00 20.00  ? 405 OCT A H31  1 
HETATM 4478 H H32  . OCT N 4 .   ? 118.173 148.752 132.887 1.00 20.00  ? 405 OCT A H32  1 
HETATM 4479 H H41  . OCT N 4 .   ? 116.115 149.559 132.144 1.00 20.00  ? 405 OCT A H41  1 
HETATM 4480 H H42  . OCT N 4 .   ? 116.789 151.129 131.698 1.00 20.00  ? 405 OCT A H42  1 
HETATM 4481 H H51  . OCT N 4 .   ? 116.336 149.016 129.980 1.00 20.00  ? 405 OCT A H51  1 
HETATM 4482 H H52  . OCT N 4 .   ? 118.068 148.926 130.296 1.00 20.00  ? 405 OCT A H52  1 
HETATM 4483 H H61  . OCT N 4 .   ? 116.686 151.477 129.484 1.00 20.00  ? 405 OCT A H61  1 
HETATM 4484 H H62  . OCT N 4 .   ? 118.420 151.131 129.500 1.00 20.00  ? 405 OCT A H62  1 
HETATM 4485 H H71  . OCT N 4 .   ? 118.128 149.475 127.751 1.00 20.00  ? 405 OCT A H71  1 
HETATM 4486 H H72  . OCT N 4 .   ? 116.384 149.720 127.775 1.00 20.00  ? 405 OCT A H72  1 
HETATM 4487 H H81  . OCT N 4 .   ? 116.542 151.446 126.361 1.00 20.00  ? 405 OCT A H81  1 
HETATM 4488 H H82  . OCT N 4 .   ? 117.742 152.232 127.398 1.00 20.00  ? 405 OCT A H82  1 
HETATM 4489 H H83  . OCT N 4 .   ? 118.261 151.062 126.175 1.00 20.00  ? 405 OCT A H83  1 
HETATM 4490 C C1   . OCT O 4 .   ? 132.273 142.026 114.927 1.00 20.00  ? 406 OCT A C1   1 
HETATM 4491 C C2   . OCT O 4 .   ? 131.434 142.844 113.967 1.00 20.00  ? 406 OCT A C2   1 
HETATM 4492 C C3   . OCT O 4 .   ? 131.446 142.225 112.587 1.00 20.00  ? 406 OCT A C3   1 
HETATM 4493 C C4   . OCT O 4 .   ? 131.075 143.297 111.588 1.00 20.00  ? 406 OCT A C4   1 
HETATM 4494 C C5   . OCT O 4 .   ? 130.801 142.733 110.212 1.00 20.00  ? 406 OCT A C5   1 
HETATM 4495 C C6   . OCT O 4 .   ? 129.925 143.717 109.468 1.00 20.00  ? 406 OCT A C6   1 
HETATM 4496 C C7   . OCT O 4 .   ? 130.277 143.809 107.996 1.00 20.00  ? 406 OCT A C7   1 
HETATM 4497 C C8   . OCT O 4 .   ? 129.992 145.201 107.464 1.00 20.00  ? 406 OCT A C8   1 
HETATM 4498 H H11  . OCT O 4 .   ? 132.146 142.411 115.930 1.00 20.00  ? 406 OCT A H11  1 
HETATM 4499 H H12  . OCT O 4 .   ? 131.950 140.994 114.886 1.00 20.00  ? 406 OCT A H12  1 
HETATM 4500 H H13  . OCT O 4 .   ? 133.311 142.095 114.637 1.00 20.00  ? 406 OCT A H13  1 
HETATM 4501 H H21  . OCT O 4 .   ? 131.836 143.846 113.904 1.00 20.00  ? 406 OCT A H21  1 
HETATM 4502 H H22  . OCT O 4 .   ? 130.415 142.886 114.326 1.00 20.00  ? 406 OCT A H22  1 
HETATM 4503 H H31  . OCT O 4 .   ? 132.436 141.847 112.367 1.00 20.00  ? 406 OCT A H31  1 
HETATM 4504 H H32  . OCT O 4 .   ? 130.725 141.420 112.541 1.00 20.00  ? 406 OCT A H32  1 
HETATM 4505 H H41  . OCT O 4 .   ? 130.187 143.803 111.940 1.00 20.00  ? 406 OCT A H41  1 
HETATM 4506 H H42  . OCT O 4 .   ? 131.885 144.011 111.518 1.00 20.00  ? 406 OCT A H42  1 
HETATM 4507 H H51  . OCT O 4 .   ? 130.289 141.787 110.307 1.00 20.00  ? 406 OCT A H51  1 
HETATM 4508 H H52  . OCT O 4 .   ? 131.737 142.594 109.688 1.00 20.00  ? 406 OCT A H52  1 
HETATM 4509 H H61  . OCT O 4 .   ? 128.892 143.414 109.567 1.00 20.00  ? 406 OCT A H61  1 
HETATM 4510 H H62  . OCT O 4 .   ? 130.051 144.696 109.912 1.00 20.00  ? 406 OCT A H62  1 
HETATM 4511 H H71  . OCT O 4 .   ? 131.329 143.593 107.863 1.00 20.00  ? 406 OCT A H71  1 
HETATM 4512 H H72  . OCT O 4 .   ? 129.688 143.089 107.445 1.00 20.00  ? 406 OCT A H72  1 
HETATM 4513 H H81  . OCT O 4 .   ? 129.013 145.514 107.806 1.00 20.00  ? 406 OCT A H81  1 
HETATM 4514 H H82  . OCT O 4 .   ? 130.742 145.885 107.839 1.00 20.00  ? 406 OCT A H82  1 
HETATM 4515 H H83  . OCT O 4 .   ? 130.014 145.185 106.383 1.00 20.00  ? 406 OCT A H83  1 
HETATM 4516 C C1   . OCT P 4 .   ? 125.200 152.988 133.309 1.00 20.00  ? 407 OCT A C1   1 
HETATM 4517 C C2   . OCT P 4 .   ? 126.023 153.158 132.046 1.00 20.00  ? 407 OCT A C2   1 
HETATM 4518 C C3   . OCT P 4 .   ? 125.438 152.375 130.891 1.00 20.00  ? 407 OCT A C3   1 
HETATM 4519 C C4   . OCT P 4 .   ? 126.550 152.036 129.926 1.00 20.00  ? 407 OCT A C4   1 
HETATM 4520 C C5   . OCT P 4 .   ? 126.001 151.307 128.722 1.00 20.00  ? 407 OCT A C5   1 
HETATM 4521 C C6   . OCT P 4 .   ? 125.582 152.241 127.604 1.00 20.00  ? 407 OCT A C6   1 
HETATM 4522 C C7   . OCT P 4 .   ? 126.231 151.824 126.300 1.00 20.00  ? 407 OCT A C7   1 
HETATM 4523 C C8   . OCT P 4 .   ? 125.396 152.256 125.109 1.00 20.00  ? 407 OCT A C8   1 
HETATM 4524 H H11  . OCT P 4 .   ? 124.154 153.111 133.066 1.00 20.00  ? 407 OCT A H11  1 
HETATM 4525 H H12  . OCT P 4 .   ? 125.366 151.995 133.709 1.00 20.00  ? 407 OCT A H12  1 
HETATM 4526 H H13  . OCT P 4 .   ? 125.497 153.732 134.037 1.00 20.00  ? 407 OCT A H13  1 
HETATM 4527 H H21  . OCT P 4 .   ? 127.029 152.808 132.230 1.00 20.00  ? 407 OCT A H21  1 
HETATM 4528 H H22  . OCT P 4 .   ? 126.051 154.206 131.782 1.00 20.00  ? 407 OCT A H22  1 
HETATM 4529 H H31  . OCT P 4 .   ? 124.991 151.466 131.264 1.00 20.00  ? 407 OCT A H31  1 
HETATM 4530 H H32  . OCT P 4 .   ? 124.691 152.972 130.386 1.00 20.00  ? 407 OCT A H32  1 
HETATM 4531 H H41  . OCT P 4 .   ? 127.037 152.948 129.613 1.00 20.00  ? 407 OCT A H41  1 
HETATM 4532 H H42  . OCT P 4 .   ? 127.267 151.400 130.429 1.00 20.00  ? 407 OCT A H42  1 
HETATM 4533 H H51  . OCT P 4 .   ? 125.139 150.732 129.035 1.00 20.00  ? 407 OCT A H51  1 
HETATM 4534 H H52  . OCT P 4 .   ? 126.762 150.637 128.352 1.00 20.00  ? 407 OCT A H52  1 
HETATM 4535 H H61  . OCT P 4 .   ? 124.506 152.200 127.490 1.00 20.00  ? 407 OCT A H61  1 
HETATM 4536 H H62  . OCT P 4 .   ? 125.878 153.253 127.844 1.00 20.00  ? 407 OCT A H62  1 
HETATM 4537 H H71  . OCT P 4 .   ? 127.212 152.277 126.234 1.00 20.00  ? 407 OCT A H71  1 
HETATM 4538 H H72  . OCT P 4 .   ? 126.331 150.747 126.280 1.00 20.00  ? 407 OCT A H72  1 
HETATM 4539 H H81  . OCT P 4 .   ? 124.885 153.178 125.355 1.00 20.00  ? 407 OCT A H81  1 
HETATM 4540 H H82  . OCT P 4 .   ? 126.040 152.411 124.254 1.00 20.00  ? 407 OCT A H82  1 
HETATM 4541 H H83  . OCT P 4 .   ? 124.669 151.486 124.886 1.00 20.00  ? 407 OCT A H83  1 
HETATM 4542 C C1   . D10 Q 3 .   ? 140.721 145.310 135.230 1.00 20.00  ? 408 D10 A C1   1 
HETATM 4543 C C2   . D10 Q 3 .   ? 141.868 145.996 134.518 1.00 20.00  ? 408 D10 A C2   1 
HETATM 4544 C C3   . D10 Q 3 .   ? 142.267 145.186 133.302 1.00 20.00  ? 408 D10 A C3   1 
HETATM 4545 C C4   . D10 Q 3 .   ? 141.271 145.320 132.180 1.00 20.00  ? 408 D10 A C4   1 
HETATM 4546 C C5   . D10 Q 3 .   ? 141.968 145.056 130.879 1.00 20.00  ? 408 D10 A C5   1 
HETATM 4547 C C6   . D10 Q 3 .   ? 141.052 145.352 129.721 1.00 20.00  ? 408 D10 A C6   1 
HETATM 4548 C C7   . D10 Q 3 .   ? 141.880 145.353 128.456 1.00 20.00  ? 408 D10 A C7   1 
HETATM 4549 C C8   . D10 Q 3 .   ? 141.266 144.502 127.379 1.00 20.00  ? 408 D10 A C8   1 
HETATM 4550 C C9   . D10 Q 3 .   ? 140.431 145.347 126.447 1.00 20.00  ? 408 D10 A C9   1 
HETATM 4551 C C10  . D10 Q 3 .   ? 141.161 145.592 125.140 1.00 20.00  ? 408 D10 A C10  1 
HETATM 4552 H H11  . D10 Q 3 .   ? 139.789 145.608 134.768 1.00 20.00  ? 408 D10 A H11  1 
HETATM 4553 H H12  . D10 Q 3 .   ? 140.837 144.238 135.148 1.00 20.00  ? 408 D10 A H12  1 
HETATM 4554 H H13  . D10 Q 3 .   ? 140.722 145.601 136.272 1.00 20.00  ? 408 D10 A H13  1 
HETATM 4555 H H21  . D10 Q 3 .   ? 142.713 146.074 135.190 1.00 20.00  ? 408 D10 A H21  1 
HETATM 4556 H H22  . D10 Q 3 .   ? 141.558 146.983 134.202 1.00 20.00  ? 408 D10 A H22  1 
HETATM 4557 H H31  . D10 Q 3 .   ? 142.347 144.144 133.578 1.00 20.00  ? 408 D10 A H31  1 
HETATM 4558 H H32  . D10 Q 3 .   ? 143.231 145.534 132.953 1.00 20.00  ? 408 D10 A H32  1 
HETATM 4559 H H41  . D10 Q 3 .   ? 140.861 146.320 132.176 1.00 20.00  ? 408 D10 A H41  1 
HETATM 4560 H H42  . D10 Q 3 .   ? 140.472 144.598 132.313 1.00 20.00  ? 408 D10 A H42  1 
HETATM 4561 H H51  . D10 Q 3 .   ? 142.841 145.692 130.808 1.00 20.00  ? 408 D10 A H51  1 
HETATM 4562 H H52  . D10 Q 3 .   ? 142.272 144.021 130.838 1.00 20.00  ? 408 D10 A H52  1 
HETATM 4563 H H61  . D10 Q 3 .   ? 140.281 144.596 129.671 1.00 20.00  ? 408 D10 A H61  1 
HETATM 4564 H H62  . D10 Q 3 .   ? 140.602 146.325 129.859 1.00 20.00  ? 408 D10 A H62  1 
HETATM 4565 H H71  . D10 Q 3 .   ? 141.983 146.367 128.097 1.00 20.00  ? 408 D10 A H71  1 
HETATM 4566 H H72  . D10 Q 3 .   ? 142.861 144.961 128.688 1.00 20.00  ? 408 D10 A H72  1 
HETATM 4567 H H81  . D10 Q 3 .   ? 140.650 143.731 127.821 1.00 20.00  ? 408 D10 A H81  1 
HETATM 4568 H H82  . D10 Q 3 .   ? 142.057 144.039 126.804 1.00 20.00  ? 408 D10 A H82  1 
HETATM 4569 H H91  . D10 Q 3 .   ? 140.208 146.294 126.917 1.00 20.00  ? 408 D10 A H91  1 
HETATM 4570 H H92  . D10 Q 3 .   ? 139.504 144.828 126.237 1.00 20.00  ? 408 D10 A H92  1 
HETATM 4571 H H101 . D10 Q 3 .   ? 141.248 144.658 124.601 1.00 20.00  ? 408 D10 A H101 1 
HETATM 4572 H H102 . D10 Q 3 .   ? 142.148 145.980 125.359 1.00 20.00  ? 408 D10 A H102 1 
HETATM 4573 H H103 . D10 Q 3 .   ? 140.607 146.310 124.547 1.00 20.00  ? 408 D10 A H103 1 
HETATM 4574 C C1   . OCT R 4 .   ? 121.782 103.476 116.581 1.00 20.00  ? 409 OCT A C1   1 
HETATM 4575 C C2   . OCT R 4 .   ? 121.474 102.109 116.012 1.00 20.00  ? 409 OCT A C2   1 
HETATM 4576 C C3   . OCT R 4 .   ? 121.973 101.982 114.586 1.00 20.00  ? 409 OCT A C3   1 
HETATM 4577 C C4   . OCT R 4 .   ? 121.304 100.825 113.867 1.00 20.00  ? 409 OCT A C4   1 
HETATM 4578 C C5   . OCT R 4 .   ? 121.748 100.785 112.415 1.00 20.00  ? 409 OCT A C5   1 
HETATM 4579 C C6   . OCT R 4 .   ? 121.036 99.706  111.625 1.00 20.00  ? 409 OCT A C6   1 
HETATM 4580 C C7   . OCT R 4 .   ? 121.740 99.444  110.306 1.00 20.00  ? 409 OCT A C7   1 
HETATM 4581 C C8   . OCT R 4 .   ? 120.942 98.504  109.416 1.00 20.00  ? 409 OCT A C8   1 
HETATM 4582 H H11  . OCT R 4 .   ? 121.644 103.460 117.653 1.00 20.00  ? 409 OCT A H11  1 
HETATM 4583 H H12  . OCT R 4 .   ? 122.809 103.731 116.347 1.00 20.00  ? 409 OCT A H12  1 
HETATM 4584 H H13  . OCT R 4 .   ? 121.118 104.204 116.135 1.00 20.00  ? 409 OCT A H13  1 
HETATM 4585 H H21  . OCT R 4 .   ? 120.404 101.953 116.021 1.00 20.00  ? 409 OCT A H21  1 
HETATM 4586 H H22  . OCT R 4 .   ? 121.953 101.354 116.621 1.00 20.00  ? 409 OCT A H22  1 
HETATM 4587 H H31  . OCT R 4 .   ? 121.759 102.898 114.056 1.00 20.00  ? 409 OCT A H31  1 
HETATM 4588 H H32  . OCT R 4 .   ? 123.042 101.818 114.598 1.00 20.00  ? 409 OCT A H32  1 
HETATM 4589 H H41  . OCT R 4 .   ? 121.577 99.897  114.350 1.00 20.00  ? 409 OCT A H41  1 
HETATM 4590 H H42  . OCT R 4 .   ? 120.231 100.952 113.906 1.00 20.00  ? 409 OCT A H42  1 
HETATM 4591 H H51  . OCT R 4 .   ? 122.812 100.595 112.380 1.00 20.00  ? 409 OCT A H51  1 
HETATM 4592 H H52  . OCT R 4 .   ? 121.544 101.744 111.961 1.00 20.00  ? 409 OCT A H52  1 
HETATM 4593 H H61  . OCT R 4 .   ? 121.018 98.795  112.207 1.00 20.00  ? 409 OCT A H61  1 
HETATM 4594 H H62  . OCT R 4 .   ? 120.021 100.026 111.428 1.00 20.00  ? 409 OCT A H62  1 
HETATM 4595 H H71  . OCT R 4 .   ? 121.879 100.386 109.794 1.00 20.00  ? 409 OCT A H71  1 
HETATM 4596 H H72  . OCT R 4 .   ? 122.707 99.003  110.510 1.00 20.00  ? 409 OCT A H72  1 
HETATM 4597 H H81  . OCT R 4 .   ? 120.963 98.867  108.397 1.00 20.00  ? 409 OCT A H81  1 
HETATM 4598 H H82  . OCT R 4 .   ? 121.376 97.514  109.459 1.00 20.00  ? 409 OCT A H82  1 
HETATM 4599 H H83  . OCT R 4 .   ? 119.919 98.467  109.769 1.00 20.00  ? 409 OCT A H83  1 
HETATM 4600 C C1   . HEX S 6 .   ? 136.431 99.126  131.097 1.00 20.00  ? 410 HEX A C1   1 
HETATM 4601 C C2   . HEX S 6 .   ? 137.693 99.889  130.716 1.00 20.00  ? 410 HEX A C2   1 
HETATM 4602 C C3   . HEX S 6 .   ? 138.229 99.439  129.367 1.00 20.00  ? 410 HEX A C3   1 
HETATM 4603 C C4   . HEX S 6 .   ? 137.282 99.816  128.239 1.00 20.00  ? 410 HEX A C4   1 
HETATM 4604 C C5   . HEX S 6 .   ? 138.010 99.855  126.905 1.00 20.00  ? 410 HEX A C5   1 
HETATM 4605 C C6   . HEX S 6 .   ? 138.640 101.216 126.654 1.00 20.00  ? 410 HEX A C6   1 
HETATM 4606 H H11  . HEX S 6 .   ? 135.565 99.666  130.736 1.00 20.00  ? 410 HEX A H11  1 
HETATM 4607 H H12  . HEX S 6 .   ? 136.382 99.026  132.173 1.00 20.00  ? 410 HEX A H12  1 
HETATM 4608 H H13  . HEX S 6 .   ? 136.460 98.143  130.639 1.00 20.00  ? 410 HEX A H13  1 
HETATM 4609 H H21  . HEX S 6 .   ? 138.449 99.722  131.469 1.00 20.00  ? 410 HEX A H21  1 
HETATM 4610 H H22  . HEX S 6 .   ? 137.463 100.945 130.662 1.00 20.00  ? 410 HEX A H22  1 
HETATM 4611 H H31  . HEX S 6 .   ? 138.353 98.364  129.376 1.00 20.00  ? 410 HEX A H31  1 
HETATM 4612 H H32  . HEX S 6 .   ? 139.189 99.908  129.195 1.00 20.00  ? 410 HEX A H32  1 
HETATM 4613 H H41  . HEX S 6 .   ? 136.484 99.088  128.186 1.00 20.00  ? 410 HEX A H41  1 
HETATM 4614 H H42  . HEX S 6 .   ? 136.865 100.794 128.443 1.00 20.00  ? 410 HEX A H42  1 
HETATM 4615 H H51  . HEX S 6 .   ? 138.787 99.102  126.913 1.00 20.00  ? 410 HEX A H51  1 
HETATM 4616 H H52  . HEX S 6 .   ? 137.307 99.639  126.111 1.00 20.00  ? 410 HEX A H52  1 
HETATM 4617 H H61  . HEX S 6 .   ? 139.043 101.246 125.651 1.00 20.00  ? 410 HEX A H61  1 
HETATM 4618 H H62  . HEX S 6 .   ? 139.435 101.377 127.371 1.00 20.00  ? 410 HEX A H62  1 
HETATM 4619 H H63  . HEX S 6 .   ? 137.886 101.983 126.771 1.00 20.00  ? 410 HEX A H63  1 
HETATM 4620 C C1   . EIC T 5 .   ? 124.771 141.276 133.568 1.00 20.00  ? 411 EIC A C1   1 
HETATM 4621 C C2   . EIC T 5 .   ? 124.978 141.070 132.074 1.00 20.00  ? 411 EIC A C2   1 
HETATM 4622 C C3   . EIC T 5 .   ? 124.041 140.027 131.444 1.00 20.00  ? 411 EIC A C3   1 
HETATM 4623 C C4   . EIC T 5 .   ? 124.832 138.966 130.672 1.00 20.00  ? 411 EIC A C4   1 
HETATM 4624 C C5   . EIC T 5 .   ? 123.887 138.069 129.866 1.00 20.00  ? 411 EIC A C5   1 
HETATM 4625 C C6   . EIC T 5 .   ? 124.594 136.787 129.411 1.00 20.00  ? 411 EIC A C6   1 
HETATM 4626 C C7   . EIC T 5 .   ? 124.928 136.855 127.918 1.00 20.00  ? 411 EIC A C7   1 
HETATM 4627 C C8   . EIC T 5 .   ? 123.918 136.089 127.065 1.00 20.00  ? 411 EIC A C8   1 
HETATM 4628 C C9   . EIC T 5 .   ? 124.489 135.870 125.686 1.00 20.00  ? 411 EIC A C9   1 
HETATM 4629 C C10  . EIC T 5 .   ? 123.892 136.063 124.511 1.00 20.00  ? 411 EIC A C10  1 
HETATM 4630 C C11  . EIC T 5 .   ? 122.491 136.553 124.236 1.00 20.00  ? 411 EIC A C11  1 
HETATM 4631 C C12  . EIC T 5 .   ? 122.104 136.134 122.837 1.00 20.00  ? 411 EIC A C12  1 
HETATM 4632 C C13  . EIC T 5 .   ? 121.964 136.890 121.743 1.00 20.00  ? 411 EIC A C13  1 
HETATM 4633 C C14  . EIC T 5 .   ? 122.148 138.385 121.619 1.00 20.00  ? 411 EIC A C14  1 
HETATM 4634 C C15  . EIC T 5 .   ? 121.457 138.919 120.356 1.00 20.00  ? 411 EIC A C15  1 
HETATM 4635 C C16  . EIC T 5 .   ? 122.273 140.008 119.654 1.00 20.00  ? 411 EIC A C16  1 
HETATM 4636 C C17  . EIC T 5 .   ? 122.107 141.360 120.355 1.00 20.00  ? 411 EIC A C17  1 
HETATM 4637 C C18  . EIC T 5 .   ? 122.990 142.429 119.701 1.00 20.00  ? 411 EIC A C18  1 
HETATM 4638 O O1   . EIC T 5 .   ? 123.711 141.717 133.960 1.00 20.00  ? 411 EIC A O1   1 
HETATM 4639 O O2   . EIC T 5 .   ? 125.694 140.989 134.287 1.00 20.00  ? 411 EIC A O2   1 
HETATM 4640 H H21  . EIC T 5 .   ? 126.021 140.769 131.913 1.00 20.00  ? 411 EIC A H21  1 
HETATM 4641 H H22  . EIC T 5 .   ? 124.838 142.038 131.578 1.00 20.00  ? 411 EIC A H22  1 
HETATM 4642 H H31  . EIC T 5 .   ? 123.334 140.528 130.770 1.00 20.00  ? 411 EIC A H31  1 
HETATM 4643 H H32  . EIC T 5 .   ? 123.450 139.544 132.232 1.00 20.00  ? 411 EIC A H32  1 
HETATM 4644 H H41  . EIC T 5 .   ? 125.408 138.361 131.383 1.00 20.00  ? 411 EIC A H41  1 
HETATM 4645 H H42  . EIC T 5 .   ? 125.549 139.456 130.000 1.00 20.00  ? 411 EIC A H42  1 
HETATM 4646 H H51  . EIC T 5 .   ? 123.510 138.625 128.999 1.00 20.00  ? 411 EIC A H51  1 
HETATM 4647 H H52  . EIC T 5 .   ? 123.021 137.809 130.486 1.00 20.00  ? 411 EIC A H52  1 
HETATM 4648 H H61  . EIC T 5 .   ? 123.946 135.922 129.612 1.00 20.00  ? 411 EIC A H61  1 
HETATM 4649 H H62  . EIC T 5 .   ? 125.519 136.655 129.989 1.00 20.00  ? 411 EIC A H62  1 
HETATM 4650 H H71  . EIC T 5 .   ? 125.930 136.440 127.758 1.00 20.00  ? 411 EIC A H71  1 
HETATM 4651 H H72  . EIC T 5 .   ? 124.954 137.903 127.591 1.00 20.00  ? 411 EIC A H72  1 
HETATM 4652 H H81  . EIC T 5 .   ? 122.990 136.668 127.001 1.00 20.00  ? 411 EIC A H81  1 
HETATM 4653 H H82  . EIC T 5 .   ? 123.666 135.148 127.562 1.00 20.00  ? 411 EIC A H82  1 
HETATM 4654 H H91  . EIC T 5 .   ? 125.516 135.509 125.694 1.00 20.00  ? 411 EIC A H91  1 
HETATM 4655 H H1O1 . EIC T 5 .   ? 124.457 135.852 123.602 1.00 20.00  ? 411 EIC A H1O1 1 
HETATM 4656 H H111 . EIC T 5 .   ? 122.418 137.642 124.319 1.00 20.00  ? 411 EIC A H111 1 
HETATM 4657 H H112 . EIC T 5 .   ? 121.819 136.129 124.989 1.00 20.00  ? 411 EIC A H112 1 
HETATM 4658 H H121 . EIC T 5 .   ? 121.932 135.062 122.747 1.00 20.00  ? 411 EIC A H121 1 
HETATM 4659 H H131 . EIC T 5 .   ? 121.679 136.402 120.813 1.00 20.00  ? 411 EIC A H131 1 
HETATM 4660 H H141 . EIC T 5 .   ? 123.204 138.671 121.598 1.00 20.00  ? 411 EIC A H141 1 
HETATM 4661 H H142 . EIC T 5 .   ? 121.712 138.877 122.498 1.00 20.00  ? 411 EIC A H142 1 
HETATM 4662 H H151 . EIC T 5 .   ? 120.486 139.334 120.639 1.00 20.00  ? 411 EIC A H151 1 
HETATM 4663 H H152 . EIC T 5 .   ? 121.276 138.096 119.652 1.00 20.00  ? 411 EIC A H152 1 
HETATM 4664 H H161 . EIC T 5 .   ? 121.936 140.098 118.613 1.00 20.00  ? 411 EIC A H161 1 
HETATM 4665 H H162 . EIC T 5 .   ? 123.335 139.727 119.637 1.00 20.00  ? 411 EIC A H162 1 
HETATM 4666 H H171 . EIC T 5 .   ? 122.372 141.262 121.415 1.00 20.00  ? 411 EIC A H171 1 
HETATM 4667 H H172 . EIC T 5 .   ? 121.059 141.678 120.306 1.00 20.00  ? 411 EIC A H172 1 
HETATM 4668 H H181 . EIC T 5 .   ? 123.890 142.601 120.302 1.00 20.00  ? 411 EIC A H181 1 
HETATM 4669 H H182 . EIC T 5 .   ? 123.301 142.110 118.697 1.00 20.00  ? 411 EIC A H182 1 
HETATM 4670 H H183 . EIC T 5 .   ? 122.452 143.382 119.610 1.00 20.00  ? 411 EIC A H183 1 
HETATM 4671 K K    . K   U 7 .   ? 123.861 123.824 134.904 1.00 44.37  ? 412 K   A K    1 
HETATM 4672 K K    . K   V 7 .   ? 123.863 123.823 129.063 1.00 33.61  ? 413 K   A K    1 
HETATM 4673 K K    . K   W 7 .   ? 123.862 123.824 125.303 1.00 52.23  ? 414 K   A K    1 
HETATM 4674 K K    . K   X 7 .   ? 123.861 123.822 131.880 1.00 60.30  ? 415 K   A K    1 
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