data_9C07
# 
_entry.id   9C07 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9C07         pdb_00009c07 10.2210/pdb9c07/pdb 
WWPDB D_1000284393 ?            ?                   
EMDB  EMD-45075    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-02-26 ? 
2 'EM metadata'     1 0 2025-02-26 ? 
3 'Half map'        1 0 2025-02-26 1 
4 'Half map'        1 0 2025-02-26 2 
5 Image             1 0 2025-02-26 ? 
6 'Primary map'     1 0 2025-02-26 ? 
7 'Structure model' 1 1 2025-03-12 ? 
8 'Structure model' 1 2 2025-05-14 ? 
9 'EM metadata'     1 1 2025-05-14 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Half map'        repository 'Initial release' ? ? 
4 4 'Half map'        repository 'Initial release' ? ? 
5 5 Image             repository 'Initial release' ? ? 
6 6 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 7 'Structure model' 'Data collection'      
2 7 'Structure model' 'Database references'  
3 8 'Structure model' 'Data collection'      
4 9 'EM metadata'     'Data processing'      
5 9 'EM metadata'     'Experimental summary' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 7 'Structure model' citation        
2 7 'Structure model' citation_author 
3 7 'Structure model' em_admin        
4 8 'Structure model' em_admin        
5 8 'Structure model' em_software     
6 9 'EM metadata'     em_admin        
7 9 'EM metadata'     em_software     
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  7 'Structure model' '_citation.country'                 
2  7 'Structure model' '_citation.journal_abbrev'          
3  7 'Structure model' '_citation.journal_id_CSD'          
4  7 'Structure model' '_citation.journal_id_ISSN'         
5  7 'Structure model' '_citation.pdbx_database_id_DOI'    
6  7 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  7 'Structure model' '_citation.title'                   
8  7 'Structure model' '_citation.year'                    
9  7 'Structure model' '_em_admin.last_update'             
10 8 'Structure model' '_em_admin.last_update'             
11 8 'Structure model' '_em_software.name'                 
12 9 'EM metadata'     '_em_admin.last_update'             
13 9 'EM metadata'     '_em_software.name'                 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9C07 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_database_related.db_name 
_pdbx_database_related.details 
_pdbx_database_related.db_id 
_pdbx_database_related.content_type 
PDB  .                                                 9BSN      unspecified            
EMDB .                                                 EMD-44870 'other EM volume'      
EMDB 'Structure of K2P13.1 (THIK1) S136P in detergent' EMD-45075 'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              daniel.minor@ucsf.edu 
_pdbx_contact_author.name_first         Daniel 
_pdbx_contact_author.name_last          Minor 
_pdbx_contact_author.name_mi            L. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-5998-4214 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Roy-Chowdhury, S.'  1 0000-0001-7128-7668 
'Adberemane-Ali, F.' 2 0000-0002-7097-1684 
'Minor, D.L.'        3 0000-0002-5998-4214 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Nat.Struct.Mol.Biol. 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1545-9985 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            ? 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1038/s41594-024-01476-3 
_citation.pdbx_database_id_PubMed   40011746 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Roy-Chowdhury, S.'  1 ?                   
primary 'Jang, S.'           2 ?                   
primary 'Abderemane-Ali, F.' 3 0000-0002-7097-1684 
primary 'Naughton, F.'       4 0000-0003-0162-1346 
primary 'Grabe, M.'          5 0000-0003-3509-5997 
primary 'Minor Jr., D.L.'    6 0000-0002-5998-4214 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Potassium channel subfamily K member 13' 39383.613 2  ? 'N59Q. N65Q, S136P' 
'K2P13.1 (THIK1) residues 1 to 350 followed by SNS linker and 3c protease cleavage site' ? 
2 non-polymer syn DODECANE                                  170.335   6  ? ?                   ? ? 
3 non-polymer syn N-OCTANE                                  114.229   8  ? ?                   ? ? 
4 non-polymer syn HEXANE                                    86.175    14 ? ?                   ? ? 
5 non-polymer syn 'LINOLEIC ACID'                           280.445   2  ? ?                   ? ? 
6 non-polymer syn HEXADECANE                                226.441   2  ? ?                   ? ? 
7 non-polymer syn 'POTASSIUM ION'                           39.098    4  ? ?                   ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Tandem pore domain halothane-inhibited potassium channel 1,THIK-1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLAQFSRGHQLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCPSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLAQFSRGHQLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCPSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_entity_poly.pdbx_strand_id                 U,A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 DODECANE        D12 
3 N-OCTANE        OCT 
4 HEXANE          HEX 
5 'LINOLEIC ACID' EIC 
6 HEXADECANE      R16 
7 'POTASSIUM ION' K   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   GLY n 
1 4   ARG n 
1 5   GLY n 
1 6   PHE n 
1 7   SER n 
1 8   TRP n 
1 9   GLY n 
1 10  PRO n 
1 11  GLY n 
1 12  HIS n 
1 13  LEU n 
1 14  ASN n 
1 15  GLU n 
1 16  ASP n 
1 17  ASN n 
1 18  ALA n 
1 19  ARG n 
1 20  PHE n 
1 21  LEU n 
1 22  LEU n 
1 23  LEU n 
1 24  ALA n 
1 25  ALA n 
1 26  LEU n 
1 27  ILE n 
1 28  VAL n 
1 29  LEU n 
1 30  TYR n 
1 31  LEU n 
1 32  LEU n 
1 33  GLY n 
1 34  GLY n 
1 35  ALA n 
1 36  ALA n 
1 37  VAL n 
1 38  PHE n 
1 39  SER n 
1 40  ALA n 
1 41  LEU n 
1 42  GLU n 
1 43  LEU n 
1 44  ALA n 
1 45  HIS n 
1 46  GLU n 
1 47  ARG n 
1 48  GLN n 
1 49  ALA n 
1 50  LYS n 
1 51  GLN n 
1 52  ARG n 
1 53  TRP n 
1 54  GLU n 
1 55  GLU n 
1 56  ARG n 
1 57  LEU n 
1 58  ALA n 
1 59  GLN n 
1 60  PHE n 
1 61  SER n 
1 62  ARG n 
1 63  GLY n 
1 64  HIS n 
1 65  GLN n 
1 66  LEU n 
1 67  SER n 
1 68  ARG n 
1 69  ASP n 
1 70  GLU n 
1 71  LEU n 
1 72  ARG n 
1 73  GLY n 
1 74  PHE n 
1 75  LEU n 
1 76  ARG n 
1 77  HIS n 
1 78  TYR n 
1 79  GLU n 
1 80  GLU n 
1 81  ALA n 
1 82  THR n 
1 83  ARG n 
1 84  ALA n 
1 85  GLY n 
1 86  ILE n 
1 87  ARG n 
1 88  VAL n 
1 89  ASP n 
1 90  ASN n 
1 91  VAL n 
1 92  ARG n 
1 93  PRO n 
1 94  ARG n 
1 95  TRP n 
1 96  ASP n 
1 97  PHE n 
1 98  THR n 
1 99  GLY n 
1 100 ALA n 
1 101 PHE n 
1 102 TYR n 
1 103 PHE n 
1 104 VAL n 
1 105 GLY n 
1 106 THR n 
1 107 VAL n 
1 108 VAL n 
1 109 SER n 
1 110 THR n 
1 111 ILE n 
1 112 GLY n 
1 113 PHE n 
1 114 GLY n 
1 115 MET n 
1 116 THR n 
1 117 THR n 
1 118 PRO n 
1 119 ALA n 
1 120 THR n 
1 121 VAL n 
1 122 GLY n 
1 123 GLY n 
1 124 LYS n 
1 125 ILE n 
1 126 PHE n 
1 127 LEU n 
1 128 ILE n 
1 129 PHE n 
1 130 TYR n 
1 131 GLY n 
1 132 LEU n 
1 133 VAL n 
1 134 GLY n 
1 135 CYS n 
1 136 PRO n 
1 137 SER n 
1 138 THR n 
1 139 ILE n 
1 140 LEU n 
1 141 PHE n 
1 142 PHE n 
1 143 ASN n 
1 144 LEU n 
1 145 PHE n 
1 146 LEU n 
1 147 GLU n 
1 148 ARG n 
1 149 LEU n 
1 150 ILE n 
1 151 THR n 
1 152 ILE n 
1 153 ILE n 
1 154 ALA n 
1 155 TYR n 
1 156 ILE n 
1 157 MET n 
1 158 LYS n 
1 159 SER n 
1 160 CYS n 
1 161 HIS n 
1 162 GLN n 
1 163 ARG n 
1 164 GLN n 
1 165 LEU n 
1 166 ARG n 
1 167 ARG n 
1 168 ARG n 
1 169 GLY n 
1 170 ALA n 
1 171 LEU n 
1 172 PRO n 
1 173 GLN n 
1 174 GLU n 
1 175 SER n 
1 176 LEU n 
1 177 LYS n 
1 178 ASP n 
1 179 ALA n 
1 180 GLY n 
1 181 GLN n 
1 182 CYS n 
1 183 GLU n 
1 184 VAL n 
1 185 ASP n 
1 186 SER n 
1 187 LEU n 
1 188 ALA n 
1 189 GLY n 
1 190 TRP n 
1 191 LYS n 
1 192 PRO n 
1 193 SER n 
1 194 VAL n 
1 195 TYR n 
1 196 TYR n 
1 197 VAL n 
1 198 MET n 
1 199 LEU n 
1 200 ILE n 
1 201 LEU n 
1 202 CYS n 
1 203 THR n 
1 204 ALA n 
1 205 SER n 
1 206 ILE n 
1 207 LEU n 
1 208 ILE n 
1 209 SER n 
1 210 CYS n 
1 211 CYS n 
1 212 ALA n 
1 213 SER n 
1 214 ALA n 
1 215 MET n 
1 216 TYR n 
1 217 THR n 
1 218 PRO n 
1 219 ILE n 
1 220 GLU n 
1 221 GLY n 
1 222 TRP n 
1 223 SER n 
1 224 TYR n 
1 225 PHE n 
1 226 ASP n 
1 227 SER n 
1 228 LEU n 
1 229 TYR n 
1 230 PHE n 
1 231 CYS n 
1 232 PHE n 
1 233 VAL n 
1 234 ALA n 
1 235 PHE n 
1 236 SER n 
1 237 THR n 
1 238 ILE n 
1 239 GLY n 
1 240 PHE n 
1 241 GLY n 
1 242 ASP n 
1 243 LEU n 
1 244 VAL n 
1 245 SER n 
1 246 SER n 
1 247 GLN n 
1 248 ASN n 
1 249 ALA n 
1 250 HIS n 
1 251 TYR n 
1 252 GLU n 
1 253 SER n 
1 254 GLN n 
1 255 GLY n 
1 256 LEU n 
1 257 TYR n 
1 258 ARG n 
1 259 PHE n 
1 260 ALA n 
1 261 ASN n 
1 262 PHE n 
1 263 VAL n 
1 264 PHE n 
1 265 ILE n 
1 266 LEU n 
1 267 MET n 
1 268 GLY n 
1 269 VAL n 
1 270 CYS n 
1 271 CYS n 
1 272 ILE n 
1 273 TYR n 
1 274 SER n 
1 275 LEU n 
1 276 PHE n 
1 277 ASN n 
1 278 VAL n 
1 279 ILE n 
1 280 SER n 
1 281 ILE n 
1 282 LEU n 
1 283 ILE n 
1 284 LYS n 
1 285 GLN n 
1 286 SER n 
1 287 LEU n 
1 288 ASN n 
1 289 TRP n 
1 290 ILE n 
1 291 LEU n 
1 292 ARG n 
1 293 LYS n 
1 294 MET n 
1 295 ASP n 
1 296 SER n 
1 297 GLY n 
1 298 CYS n 
1 299 CYS n 
1 300 PRO n 
1 301 GLN n 
1 302 CYS n 
1 303 GLN n 
1 304 ARG n 
1 305 GLY n 
1 306 LEU n 
1 307 LEU n 
1 308 ARG n 
1 309 SER n 
1 310 ARG n 
1 311 ARG n 
1 312 ASN n 
1 313 VAL n 
1 314 VAL n 
1 315 MET n 
1 316 PRO n 
1 317 GLY n 
1 318 SER n 
1 319 VAL n 
1 320 ARG n 
1 321 ASN n 
1 322 ARG n 
1 323 CYS n 
1 324 ASN n 
1 325 ILE n 
1 326 SER n 
1 327 ILE n 
1 328 GLU n 
1 329 THR n 
1 330 ASP n 
1 331 GLY n 
1 332 VAL n 
1 333 ALA n 
1 334 GLU n 
1 335 SER n 
1 336 ASP n 
1 337 THR n 
1 338 ASP n 
1 339 GLY n 
1 340 ARG n 
1 341 ARG n 
1 342 LEU n 
1 343 SER n 
1 344 GLY n 
1 345 GLU n 
1 346 MET n 
1 347 ILE n 
1 348 SER n 
1 349 MET n 
1 350 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   350 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 KCNK13 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               human 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ?                    'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ?                    'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ?                    'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                    'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ?                    'C3 H7 N O2 S'   121.158 
D12 non-polymer         . DODECANE        ?                    'C12 H26'        170.335 
EIC non-polymer         . 'LINOLEIC ACID' '9,12-LINOLEIC ACID' 'C18 H32 O2'     280.445 
GLN 'L-peptide linking' y GLUTAMINE       ?                    'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                    'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ?                    'C2 H5 N O2'     75.067  
HEX non-polymer         . HEXANE          ?                    'C6 H14'         86.175  
HIS 'L-peptide linking' y HISTIDINE       ?                    'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE      ?                    'C6 H13 N O2'    131.173 
K   non-polymer         . 'POTASSIUM ION' ?                    'K 1'            39.098  
LEU 'L-peptide linking' y LEUCINE         ?                    'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ?                    'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ?                    'C5 H11 N O2 S'  149.211 
OCT non-polymer         . N-OCTANE        ?                    'C8 H18'         114.229 
PHE 'L-peptide linking' y PHENYLALANINE   ?                    'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE         ?                    'C5 H9 N O2'     115.130 
R16 non-polymer         . HEXADECANE      ?                    'C16 H34'        226.441 
SER 'L-peptide linking' y SERINE          ?                    'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ?                    'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ?                    'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ?                    'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ?                    'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   U . n 
A 1 2   ALA 2   2   ?   ?   ?   U . n 
A 1 3   GLY 3   3   ?   ?   ?   U . n 
A 1 4   ARG 4   4   ?   ?   ?   U . n 
A 1 5   GLY 5   5   ?   ?   ?   U . n 
A 1 6   PHE 6   6   ?   ?   ?   U . n 
A 1 7   SER 7   7   ?   ?   ?   U . n 
A 1 8   TRP 8   8   ?   ?   ?   U . n 
A 1 9   GLY 9   9   ?   ?   ?   U . n 
A 1 10  PRO 10  10  ?   ?   ?   U . n 
A 1 11  GLY 11  11  ?   ?   ?   U . n 
A 1 12  HIS 12  12  ?   ?   ?   U . n 
A 1 13  LEU 13  13  ?   ?   ?   U . n 
A 1 14  ASN 14  14  14  ASN ASN U . n 
A 1 15  GLU 15  15  15  GLU GLU U . n 
A 1 16  ASP 16  16  16  ASP ASP U . n 
A 1 17  ASN 17  17  17  ASN ASN U . n 
A 1 18  ALA 18  18  18  ALA ALA U . n 
A 1 19  ARG 19  19  19  ARG ARG U . n 
A 1 20  PHE 20  20  20  PHE PHE U . n 
A 1 21  LEU 21  21  21  LEU LEU U . n 
A 1 22  LEU 22  22  22  LEU LEU U . n 
A 1 23  LEU 23  23  23  LEU LEU U . n 
A 1 24  ALA 24  24  24  ALA ALA U . n 
A 1 25  ALA 25  25  25  ALA ALA U . n 
A 1 26  LEU 26  26  26  LEU LEU U . n 
A 1 27  ILE 27  27  27  ILE ILE U . n 
A 1 28  VAL 28  28  28  VAL VAL U . n 
A 1 29  LEU 29  29  29  LEU LEU U . n 
A 1 30  TYR 30  30  30  TYR TYR U . n 
A 1 31  LEU 31  31  31  LEU LEU U . n 
A 1 32  LEU 32  32  32  LEU LEU U . n 
A 1 33  GLY 33  33  33  GLY GLY U . n 
A 1 34  GLY 34  34  34  GLY GLY U . n 
A 1 35  ALA 35  35  35  ALA ALA U . n 
A 1 36  ALA 36  36  36  ALA ALA U . n 
A 1 37  VAL 37  37  37  VAL VAL U . n 
A 1 38  PHE 38  38  38  PHE PHE U . n 
A 1 39  SER 39  39  39  SER SER U . n 
A 1 40  ALA 40  40  40  ALA ALA U . n 
A 1 41  LEU 41  41  41  LEU LEU U . n 
A 1 42  GLU 42  42  42  GLU GLU U . n 
A 1 43  LEU 43  43  43  LEU LEU U . n 
A 1 44  ALA 44  44  44  ALA ALA U . n 
A 1 45  HIS 45  45  45  HIS HIS U . n 
A 1 46  GLU 46  46  46  GLU GLU U . n 
A 1 47  ARG 47  47  47  ARG ARG U . n 
A 1 48  GLN 48  48  48  GLN GLN U . n 
A 1 49  ALA 49  49  49  ALA ALA U . n 
A 1 50  LYS 50  50  50  LYS LYS U . n 
A 1 51  GLN 51  51  51  GLN GLN U . n 
A 1 52  ARG 52  52  52  ARG ARG U . n 
A 1 53  TRP 53  53  53  TRP TRP U . n 
A 1 54  GLU 54  54  54  GLU GLU U . n 
A 1 55  GLU 55  55  55  GLU GLU U . n 
A 1 56  ARG 56  56  56  ARG ARG U . n 
A 1 57  LEU 57  57  57  LEU LEU U . n 
A 1 58  ALA 58  58  58  ALA ALA U . n 
A 1 59  GLN 59  59  59  GLN GLN U . n 
A 1 60  PHE 60  60  60  PHE PHE U . n 
A 1 61  SER 61  61  61  SER SER U . n 
A 1 62  ARG 62  62  62  ARG ARG U . n 
A 1 63  GLY 63  63  63  GLY GLY U . n 
A 1 64  HIS 64  64  64  HIS HIS U . n 
A 1 65  GLN 65  65  65  GLN GLN U . n 
A 1 66  LEU 66  66  66  LEU LEU U . n 
A 1 67  SER 67  67  67  SER SER U . n 
A 1 68  ARG 68  68  68  ARG ARG U . n 
A 1 69  ASP 69  69  69  ASP ASP U . n 
A 1 70  GLU 70  70  70  GLU GLU U . n 
A 1 71  LEU 71  71  71  LEU LEU U . n 
A 1 72  ARG 72  72  72  ARG ARG U . n 
A 1 73  GLY 73  73  73  GLY GLY U . n 
A 1 74  PHE 74  74  74  PHE PHE U . n 
A 1 75  LEU 75  75  75  LEU LEU U . n 
A 1 76  ARG 76  76  76  ARG ARG U . n 
A 1 77  HIS 77  77  77  HIS HIS U . n 
A 1 78  TYR 78  78  78  TYR TYR U . n 
A 1 79  GLU 79  79  79  GLU GLU U . n 
A 1 80  GLU 80  80  80  GLU GLU U . n 
A 1 81  ALA 81  81  81  ALA ALA U . n 
A 1 82  THR 82  82  82  THR THR U . n 
A 1 83  ARG 83  83  83  ARG ARG U . n 
A 1 84  ALA 84  84  84  ALA ALA U . n 
A 1 85  GLY 85  85  85  GLY GLY U . n 
A 1 86  ILE 86  86  86  ILE ILE U . n 
A 1 87  ARG 87  87  87  ARG ARG U . n 
A 1 88  VAL 88  88  88  VAL VAL U . n 
A 1 89  ASP 89  89  89  ASP ASP U . n 
A 1 90  ASN 90  90  90  ASN ASN U . n 
A 1 91  VAL 91  91  91  VAL VAL U . n 
A 1 92  ARG 92  92  92  ARG ARG U . n 
A 1 93  PRO 93  93  93  PRO PRO U . n 
A 1 94  ARG 94  94  94  ARG ARG U . n 
A 1 95  TRP 95  95  95  TRP TRP U . n 
A 1 96  ASP 96  96  96  ASP ASP U . n 
A 1 97  PHE 97  97  97  PHE PHE U . n 
A 1 98  THR 98  98  98  THR THR U . n 
A 1 99  GLY 99  99  99  GLY GLY U . n 
A 1 100 ALA 100 100 100 ALA ALA U . n 
A 1 101 PHE 101 101 101 PHE PHE U . n 
A 1 102 TYR 102 102 102 TYR TYR U . n 
A 1 103 PHE 103 103 103 PHE PHE U . n 
A 1 104 VAL 104 104 104 VAL VAL U . n 
A 1 105 GLY 105 105 105 GLY GLY U . n 
A 1 106 THR 106 106 106 THR THR U . n 
A 1 107 VAL 107 107 107 VAL VAL U . n 
A 1 108 VAL 108 108 108 VAL VAL U . n 
A 1 109 SER 109 109 109 SER SER U . n 
A 1 110 THR 110 110 110 THR THR U . n 
A 1 111 ILE 111 111 111 ILE ILE U . n 
A 1 112 GLY 112 112 112 GLY GLY U . n 
A 1 113 PHE 113 113 113 PHE PHE U . n 
A 1 114 GLY 114 114 114 GLY GLY U . n 
A 1 115 MET 115 115 115 MET MET U . n 
A 1 116 THR 116 116 116 THR THR U . n 
A 1 117 THR 117 117 117 THR THR U . n 
A 1 118 PRO 118 118 118 PRO PRO U . n 
A 1 119 ALA 119 119 119 ALA ALA U . n 
A 1 120 THR 120 120 120 THR THR U . n 
A 1 121 VAL 121 121 121 VAL VAL U . n 
A 1 122 GLY 122 122 122 GLY GLY U . n 
A 1 123 GLY 123 123 123 GLY GLY U . n 
A 1 124 LYS 124 124 124 LYS LYS U . n 
A 1 125 ILE 125 125 125 ILE ILE U . n 
A 1 126 PHE 126 126 126 PHE PHE U . n 
A 1 127 LEU 127 127 127 LEU LEU U . n 
A 1 128 ILE 128 128 128 ILE ILE U . n 
A 1 129 PHE 129 129 129 PHE PHE U . n 
A 1 130 TYR 130 130 130 TYR TYR U . n 
A 1 131 GLY 131 131 131 GLY GLY U . n 
A 1 132 LEU 132 132 132 LEU LEU U . n 
A 1 133 VAL 133 133 133 VAL VAL U . n 
A 1 134 GLY 134 134 134 GLY GLY U . n 
A 1 135 CYS 135 135 135 CYS CYS U . n 
A 1 136 PRO 136 136 136 PRO PRO U . n 
A 1 137 SER 137 137 137 SER SER U . n 
A 1 138 THR 138 138 138 THR THR U . n 
A 1 139 ILE 139 139 139 ILE ILE U . n 
A 1 140 LEU 140 140 140 LEU LEU U . n 
A 1 141 PHE 141 141 141 PHE PHE U . n 
A 1 142 PHE 142 142 142 PHE PHE U . n 
A 1 143 ASN 143 143 143 ASN ASN U . n 
A 1 144 LEU 144 144 144 LEU LEU U . n 
A 1 145 PHE 145 145 145 PHE PHE U . n 
A 1 146 LEU 146 146 146 LEU LEU U . n 
A 1 147 GLU 147 147 147 GLU GLU U . n 
A 1 148 ARG 148 148 148 ARG ARG U . n 
A 1 149 LEU 149 149 149 LEU LEU U . n 
A 1 150 ILE 150 150 150 ILE ILE U . n 
A 1 151 THR 151 151 151 THR THR U . n 
A 1 152 ILE 152 152 152 ILE ILE U . n 
A 1 153 ILE 153 153 153 ILE ILE U . n 
A 1 154 ALA 154 154 154 ALA ALA U . n 
A 1 155 TYR 155 155 155 TYR TYR U . n 
A 1 156 ILE 156 156 156 ILE ILE U . n 
A 1 157 MET 157 157 157 MET MET U . n 
A 1 158 LYS 158 158 158 LYS LYS U . n 
A 1 159 SER 159 159 159 SER SER U . n 
A 1 160 CYS 160 160 160 CYS CYS U . n 
A 1 161 HIS 161 161 161 HIS HIS U . n 
A 1 162 GLN 162 162 162 GLN GLN U . n 
A 1 163 ARG 163 163 163 ARG ARG U . n 
A 1 164 GLN 164 164 164 GLN GLN U . n 
A 1 165 LEU 165 165 165 LEU LEU U . n 
A 1 166 ARG 166 166 166 ARG ARG U . n 
A 1 167 ARG 167 167 167 ARG ARG U . n 
A 1 168 ARG 168 168 ?   ?   ?   U . n 
A 1 169 GLY 169 169 ?   ?   ?   U . n 
A 1 170 ALA 170 170 ?   ?   ?   U . n 
A 1 171 LEU 171 171 ?   ?   ?   U . n 
A 1 172 PRO 172 172 ?   ?   ?   U . n 
A 1 173 GLN 173 173 ?   ?   ?   U . n 
A 1 174 GLU 174 174 ?   ?   ?   U . n 
A 1 175 SER 175 175 ?   ?   ?   U . n 
A 1 176 LEU 176 176 ?   ?   ?   U . n 
A 1 177 LYS 177 177 ?   ?   ?   U . n 
A 1 178 ASP 178 178 ?   ?   ?   U . n 
A 1 179 ALA 179 179 ?   ?   ?   U . n 
A 1 180 GLY 180 180 ?   ?   ?   U . n 
A 1 181 GLN 181 181 ?   ?   ?   U . n 
A 1 182 CYS 182 182 ?   ?   ?   U . n 
A 1 183 GLU 183 183 ?   ?   ?   U . n 
A 1 184 VAL 184 184 ?   ?   ?   U . n 
A 1 185 ASP 185 185 ?   ?   ?   U . n 
A 1 186 SER 186 186 ?   ?   ?   U . n 
A 1 187 LEU 187 187 ?   ?   ?   U . n 
A 1 188 ALA 188 188 188 ALA ALA U . n 
A 1 189 GLY 189 189 189 GLY GLY U . n 
A 1 190 TRP 190 190 190 TRP TRP U . n 
A 1 191 LYS 191 191 191 LYS LYS U . n 
A 1 192 PRO 192 192 192 PRO PRO U . n 
A 1 193 SER 193 193 193 SER SER U . n 
A 1 194 VAL 194 194 194 VAL VAL U . n 
A 1 195 TYR 195 195 195 TYR TYR U . n 
A 1 196 TYR 196 196 196 TYR TYR U . n 
A 1 197 VAL 197 197 197 VAL VAL U . n 
A 1 198 MET 198 198 198 MET MET U . n 
A 1 199 LEU 199 199 199 LEU LEU U . n 
A 1 200 ILE 200 200 200 ILE ILE U . n 
A 1 201 LEU 201 201 201 LEU LEU U . n 
A 1 202 CYS 202 202 202 CYS CYS U . n 
A 1 203 THR 203 203 203 THR THR U . n 
A 1 204 ALA 204 204 204 ALA ALA U . n 
A 1 205 SER 205 205 205 SER SER U . n 
A 1 206 ILE 206 206 206 ILE ILE U . n 
A 1 207 LEU 207 207 207 LEU LEU U . n 
A 1 208 ILE 208 208 208 ILE ILE U . n 
A 1 209 SER 209 209 209 SER SER U . n 
A 1 210 CYS 210 210 210 CYS CYS U . n 
A 1 211 CYS 211 211 211 CYS CYS U . n 
A 1 212 ALA 212 212 212 ALA ALA U . n 
A 1 213 SER 213 213 213 SER SER U . n 
A 1 214 ALA 214 214 214 ALA ALA U . n 
A 1 215 MET 215 215 215 MET MET U . n 
A 1 216 TYR 216 216 216 TYR TYR U . n 
A 1 217 THR 217 217 217 THR THR U . n 
A 1 218 PRO 218 218 218 PRO PRO U . n 
A 1 219 ILE 219 219 219 ILE ILE U . n 
A 1 220 GLU 220 220 220 GLU GLU U . n 
A 1 221 GLY 221 221 221 GLY GLY U . n 
A 1 222 TRP 222 222 222 TRP TRP U . n 
A 1 223 SER 223 223 223 SER SER U . n 
A 1 224 TYR 224 224 224 TYR TYR U . n 
A 1 225 PHE 225 225 225 PHE PHE U . n 
A 1 226 ASP 226 226 226 ASP ASP U . n 
A 1 227 SER 227 227 227 SER SER U . n 
A 1 228 LEU 228 228 228 LEU LEU U . n 
A 1 229 TYR 229 229 229 TYR TYR U . n 
A 1 230 PHE 230 230 230 PHE PHE U . n 
A 1 231 CYS 231 231 231 CYS CYS U . n 
A 1 232 PHE 232 232 232 PHE PHE U . n 
A 1 233 VAL 233 233 233 VAL VAL U . n 
A 1 234 ALA 234 234 234 ALA ALA U . n 
A 1 235 PHE 235 235 235 PHE PHE U . n 
A 1 236 SER 236 236 236 SER SER U . n 
A 1 237 THR 237 237 237 THR THR U . n 
A 1 238 ILE 238 238 238 ILE ILE U . n 
A 1 239 GLY 239 239 239 GLY GLY U . n 
A 1 240 PHE 240 240 240 PHE PHE U . n 
A 1 241 GLY 241 241 241 GLY GLY U . n 
A 1 242 ASP 242 242 242 ASP ASP U . n 
A 1 243 LEU 243 243 243 LEU LEU U . n 
A 1 244 VAL 244 244 244 VAL VAL U . n 
A 1 245 SER 245 245 245 SER SER U . n 
A 1 246 SER 246 246 246 SER SER U . n 
A 1 247 GLN 247 247 247 GLN GLN U . n 
A 1 248 ASN 248 248 248 ASN ASN U . n 
A 1 249 ALA 249 249 249 ALA ALA U . n 
A 1 250 HIS 250 250 250 HIS HIS U . n 
A 1 251 TYR 251 251 251 TYR TYR U . n 
A 1 252 GLU 252 252 252 GLU GLU U . n 
A 1 253 SER 253 253 253 SER SER U . n 
A 1 254 GLN 254 254 254 GLN GLN U . n 
A 1 255 GLY 255 255 255 GLY GLY U . n 
A 1 256 LEU 256 256 256 LEU LEU U . n 
A 1 257 TYR 257 257 257 TYR TYR U . n 
A 1 258 ARG 258 258 258 ARG ARG U . n 
A 1 259 PHE 259 259 259 PHE PHE U . n 
A 1 260 ALA 260 260 260 ALA ALA U . n 
A 1 261 ASN 261 261 261 ASN ASN U . n 
A 1 262 PHE 262 262 262 PHE PHE U . n 
A 1 263 VAL 263 263 263 VAL VAL U . n 
A 1 264 PHE 264 264 264 PHE PHE U . n 
A 1 265 ILE 265 265 265 ILE ILE U . n 
A 1 266 LEU 266 266 266 LEU LEU U . n 
A 1 267 MET 267 267 267 MET MET U . n 
A 1 268 GLY 268 268 268 GLY GLY U . n 
A 1 269 VAL 269 269 269 VAL VAL U . n 
A 1 270 CYS 270 270 270 CYS CYS U . n 
A 1 271 CYS 271 271 271 CYS CYS U . n 
A 1 272 ILE 272 272 272 ILE ILE U . n 
A 1 273 TYR 273 273 273 TYR TYR U . n 
A 1 274 SER 274 274 274 SER SER U . n 
A 1 275 LEU 275 275 275 LEU LEU U . n 
A 1 276 PHE 276 276 276 PHE PHE U . n 
A 1 277 ASN 277 277 277 ASN ASN U . n 
A 1 278 VAL 278 278 278 VAL VAL U . n 
A 1 279 ILE 279 279 279 ILE ILE U . n 
A 1 280 SER 280 280 280 SER SER U . n 
A 1 281 ILE 281 281 281 ILE ILE U . n 
A 1 282 LEU 282 282 282 LEU LEU U . n 
A 1 283 ILE 283 283 283 ILE ILE U . n 
A 1 284 LYS 284 284 284 LYS LYS U . n 
A 1 285 GLN 285 285 285 GLN GLN U . n 
A 1 286 SER 286 286 286 SER SER U . n 
A 1 287 LEU 287 287 287 LEU LEU U . n 
A 1 288 ASN 288 288 288 ASN ASN U . n 
A 1 289 TRP 289 289 289 TRP TRP U . n 
A 1 290 ILE 290 290 290 ILE ILE U . n 
A 1 291 LEU 291 291 291 LEU LEU U . n 
A 1 292 ARG 292 292 292 ARG ARG U . n 
A 1 293 LYS 293 293 293 LYS LYS U . n 
A 1 294 MET 294 294 294 MET MET U . n 
A 1 295 ASP 295 295 295 ASP ASP U . n 
A 1 296 SER 296 296 ?   ?   ?   U . n 
A 1 297 GLY 297 297 ?   ?   ?   U . n 
A 1 298 CYS 298 298 ?   ?   ?   U . n 
A 1 299 CYS 299 299 ?   ?   ?   U . n 
A 1 300 PRO 300 300 ?   ?   ?   U . n 
A 1 301 GLN 301 301 ?   ?   ?   U . n 
A 1 302 CYS 302 302 ?   ?   ?   U . n 
A 1 303 GLN 303 303 ?   ?   ?   U . n 
A 1 304 ARG 304 304 ?   ?   ?   U . n 
A 1 305 GLY 305 305 ?   ?   ?   U . n 
A 1 306 LEU 306 306 ?   ?   ?   U . n 
A 1 307 LEU 307 307 ?   ?   ?   U . n 
A 1 308 ARG 308 308 ?   ?   ?   U . n 
A 1 309 SER 309 309 ?   ?   ?   U . n 
A 1 310 ARG 310 310 ?   ?   ?   U . n 
A 1 311 ARG 311 311 ?   ?   ?   U . n 
A 1 312 ASN 312 312 ?   ?   ?   U . n 
A 1 313 VAL 313 313 ?   ?   ?   U . n 
A 1 314 VAL 314 314 ?   ?   ?   U . n 
A 1 315 MET 315 315 ?   ?   ?   U . n 
A 1 316 PRO 316 316 ?   ?   ?   U . n 
A 1 317 GLY 317 317 ?   ?   ?   U . n 
A 1 318 SER 318 318 ?   ?   ?   U . n 
A 1 319 VAL 319 319 ?   ?   ?   U . n 
A 1 320 ARG 320 320 ?   ?   ?   U . n 
A 1 321 ASN 321 321 ?   ?   ?   U . n 
A 1 322 ARG 322 322 ?   ?   ?   U . n 
A 1 323 CYS 323 323 ?   ?   ?   U . n 
A 1 324 ASN 324 324 ?   ?   ?   U . n 
A 1 325 ILE 325 325 ?   ?   ?   U . n 
A 1 326 SER 326 326 ?   ?   ?   U . n 
A 1 327 ILE 327 327 ?   ?   ?   U . n 
A 1 328 GLU 328 328 ?   ?   ?   U . n 
A 1 329 THR 329 329 ?   ?   ?   U . n 
A 1 330 ASP 330 330 ?   ?   ?   U . n 
A 1 331 GLY 331 331 ?   ?   ?   U . n 
A 1 332 VAL 332 332 ?   ?   ?   U . n 
A 1 333 ALA 333 333 ?   ?   ?   U . n 
A 1 334 GLU 334 334 ?   ?   ?   U . n 
A 1 335 SER 335 335 ?   ?   ?   U . n 
A 1 336 ASP 336 336 ?   ?   ?   U . n 
A 1 337 THR 337 337 ?   ?   ?   U . n 
A 1 338 ASP 338 338 ?   ?   ?   U . n 
A 1 339 GLY 339 339 ?   ?   ?   U . n 
A 1 340 ARG 340 340 ?   ?   ?   U . n 
A 1 341 ARG 341 341 ?   ?   ?   U . n 
A 1 342 LEU 342 342 ?   ?   ?   U . n 
A 1 343 SER 343 343 ?   ?   ?   U . n 
A 1 344 GLY 344 344 ?   ?   ?   U . n 
A 1 345 GLU 345 345 ?   ?   ?   U . n 
A 1 346 MET 346 346 ?   ?   ?   U . n 
A 1 347 ILE 347 347 ?   ?   ?   U . n 
A 1 348 SER 348 348 ?   ?   ?   U . n 
A 1 349 MET 349 349 ?   ?   ?   U . n 
A 1 350 LYS 350 350 ?   ?   ?   U . n 
B 1 1   MET 1   1   ?   ?   ?   A . n 
B 1 2   ALA 2   2   ?   ?   ?   A . n 
B 1 3   GLY 3   3   ?   ?   ?   A . n 
B 1 4   ARG 4   4   ?   ?   ?   A . n 
B 1 5   GLY 5   5   ?   ?   ?   A . n 
B 1 6   PHE 6   6   ?   ?   ?   A . n 
B 1 7   SER 7   7   ?   ?   ?   A . n 
B 1 8   TRP 8   8   ?   ?   ?   A . n 
B 1 9   GLY 9   9   ?   ?   ?   A . n 
B 1 10  PRO 10  10  ?   ?   ?   A . n 
B 1 11  GLY 11  11  ?   ?   ?   A . n 
B 1 12  HIS 12  12  ?   ?   ?   A . n 
B 1 13  LEU 13  13  ?   ?   ?   A . n 
B 1 14  ASN 14  14  14  ASN ASN A . n 
B 1 15  GLU 15  15  15  GLU GLU A . n 
B 1 16  ASP 16  16  16  ASP ASP A . n 
B 1 17  ASN 17  17  17  ASN ASN A . n 
B 1 18  ALA 18  18  18  ALA ALA A . n 
B 1 19  ARG 19  19  19  ARG ARG A . n 
B 1 20  PHE 20  20  20  PHE PHE A . n 
B 1 21  LEU 21  21  21  LEU LEU A . n 
B 1 22  LEU 22  22  22  LEU LEU A . n 
B 1 23  LEU 23  23  23  LEU LEU A . n 
B 1 24  ALA 24  24  24  ALA ALA A . n 
B 1 25  ALA 25  25  25  ALA ALA A . n 
B 1 26  LEU 26  26  26  LEU LEU A . n 
B 1 27  ILE 27  27  27  ILE ILE A . n 
B 1 28  VAL 28  28  28  VAL VAL A . n 
B 1 29  LEU 29  29  29  LEU LEU A . n 
B 1 30  TYR 30  30  30  TYR TYR A . n 
B 1 31  LEU 31  31  31  LEU LEU A . n 
B 1 32  LEU 32  32  32  LEU LEU A . n 
B 1 33  GLY 33  33  33  GLY GLY A . n 
B 1 34  GLY 34  34  34  GLY GLY A . n 
B 1 35  ALA 35  35  35  ALA ALA A . n 
B 1 36  ALA 36  36  36  ALA ALA A . n 
B 1 37  VAL 37  37  37  VAL VAL A . n 
B 1 38  PHE 38  38  38  PHE PHE A . n 
B 1 39  SER 39  39  39  SER SER A . n 
B 1 40  ALA 40  40  40  ALA ALA A . n 
B 1 41  LEU 41  41  41  LEU LEU A . n 
B 1 42  GLU 42  42  42  GLU GLU A . n 
B 1 43  LEU 43  43  43  LEU LEU A . n 
B 1 44  ALA 44  44  44  ALA ALA A . n 
B 1 45  HIS 45  45  45  HIS HIS A . n 
B 1 46  GLU 46  46  46  GLU GLU A . n 
B 1 47  ARG 47  47  47  ARG ARG A . n 
B 1 48  GLN 48  48  48  GLN GLN A . n 
B 1 49  ALA 49  49  49  ALA ALA A . n 
B 1 50  LYS 50  50  50  LYS LYS A . n 
B 1 51  GLN 51  51  51  GLN GLN A . n 
B 1 52  ARG 52  52  52  ARG ARG A . n 
B 1 53  TRP 53  53  53  TRP TRP A . n 
B 1 54  GLU 54  54  54  GLU GLU A . n 
B 1 55  GLU 55  55  55  GLU GLU A . n 
B 1 56  ARG 56  56  56  ARG ARG A . n 
B 1 57  LEU 57  57  57  LEU LEU A . n 
B 1 58  ALA 58  58  58  ALA ALA A . n 
B 1 59  GLN 59  59  59  GLN GLN A . n 
B 1 60  PHE 60  60  60  PHE PHE A . n 
B 1 61  SER 61  61  61  SER SER A . n 
B 1 62  ARG 62  62  62  ARG ARG A . n 
B 1 63  GLY 63  63  63  GLY GLY A . n 
B 1 64  HIS 64  64  64  HIS HIS A . n 
B 1 65  GLN 65  65  65  GLN GLN A . n 
B 1 66  LEU 66  66  66  LEU LEU A . n 
B 1 67  SER 67  67  67  SER SER A . n 
B 1 68  ARG 68  68  68  ARG ARG A . n 
B 1 69  ASP 69  69  69  ASP ASP A . n 
B 1 70  GLU 70  70  70  GLU GLU A . n 
B 1 71  LEU 71  71  71  LEU LEU A . n 
B 1 72  ARG 72  72  72  ARG ARG A . n 
B 1 73  GLY 73  73  73  GLY GLY A . n 
B 1 74  PHE 74  74  74  PHE PHE A . n 
B 1 75  LEU 75  75  75  LEU LEU A . n 
B 1 76  ARG 76  76  76  ARG ARG A . n 
B 1 77  HIS 77  77  77  HIS HIS A . n 
B 1 78  TYR 78  78  78  TYR TYR A . n 
B 1 79  GLU 79  79  79  GLU GLU A . n 
B 1 80  GLU 80  80  80  GLU GLU A . n 
B 1 81  ALA 81  81  81  ALA ALA A . n 
B 1 82  THR 82  82  82  THR THR A . n 
B 1 83  ARG 83  83  83  ARG ARG A . n 
B 1 84  ALA 84  84  84  ALA ALA A . n 
B 1 85  GLY 85  85  85  GLY GLY A . n 
B 1 86  ILE 86  86  86  ILE ILE A . n 
B 1 87  ARG 87  87  87  ARG ARG A . n 
B 1 88  VAL 88  88  88  VAL VAL A . n 
B 1 89  ASP 89  89  89  ASP ASP A . n 
B 1 90  ASN 90  90  90  ASN ASN A . n 
B 1 91  VAL 91  91  91  VAL VAL A . n 
B 1 92  ARG 92  92  92  ARG ARG A . n 
B 1 93  PRO 93  93  93  PRO PRO A . n 
B 1 94  ARG 94  94  94  ARG ARG A . n 
B 1 95  TRP 95  95  95  TRP TRP A . n 
B 1 96  ASP 96  96  96  ASP ASP A . n 
B 1 97  PHE 97  97  97  PHE PHE A . n 
B 1 98  THR 98  98  98  THR THR A . n 
B 1 99  GLY 99  99  99  GLY GLY A . n 
B 1 100 ALA 100 100 100 ALA ALA A . n 
B 1 101 PHE 101 101 101 PHE PHE A . n 
B 1 102 TYR 102 102 102 TYR TYR A . n 
B 1 103 PHE 103 103 103 PHE PHE A . n 
B 1 104 VAL 104 104 104 VAL VAL A . n 
B 1 105 GLY 105 105 105 GLY GLY A . n 
B 1 106 THR 106 106 106 THR THR A . n 
B 1 107 VAL 107 107 107 VAL VAL A . n 
B 1 108 VAL 108 108 108 VAL VAL A . n 
B 1 109 SER 109 109 109 SER SER A . n 
B 1 110 THR 110 110 110 THR THR A . n 
B 1 111 ILE 111 111 111 ILE ILE A . n 
B 1 112 GLY 112 112 112 GLY GLY A . n 
B 1 113 PHE 113 113 113 PHE PHE A . n 
B 1 114 GLY 114 114 114 GLY GLY A . n 
B 1 115 MET 115 115 115 MET MET A . n 
B 1 116 THR 116 116 116 THR THR A . n 
B 1 117 THR 117 117 117 THR THR A . n 
B 1 118 PRO 118 118 118 PRO PRO A . n 
B 1 119 ALA 119 119 119 ALA ALA A . n 
B 1 120 THR 120 120 120 THR THR A . n 
B 1 121 VAL 121 121 121 VAL VAL A . n 
B 1 122 GLY 122 122 122 GLY GLY A . n 
B 1 123 GLY 123 123 123 GLY GLY A . n 
B 1 124 LYS 124 124 124 LYS LYS A . n 
B 1 125 ILE 125 125 125 ILE ILE A . n 
B 1 126 PHE 126 126 126 PHE PHE A . n 
B 1 127 LEU 127 127 127 LEU LEU A . n 
B 1 128 ILE 128 128 128 ILE ILE A . n 
B 1 129 PHE 129 129 129 PHE PHE A . n 
B 1 130 TYR 130 130 130 TYR TYR A . n 
B 1 131 GLY 131 131 131 GLY GLY A . n 
B 1 132 LEU 132 132 132 LEU LEU A . n 
B 1 133 VAL 133 133 133 VAL VAL A . n 
B 1 134 GLY 134 134 134 GLY GLY A . n 
B 1 135 CYS 135 135 135 CYS CYS A . n 
B 1 136 PRO 136 136 136 PRO PRO A . n 
B 1 137 SER 137 137 137 SER SER A . n 
B 1 138 THR 138 138 138 THR THR A . n 
B 1 139 ILE 139 139 139 ILE ILE A . n 
B 1 140 LEU 140 140 140 LEU LEU A . n 
B 1 141 PHE 141 141 141 PHE PHE A . n 
B 1 142 PHE 142 142 142 PHE PHE A . n 
B 1 143 ASN 143 143 143 ASN ASN A . n 
B 1 144 LEU 144 144 144 LEU LEU A . n 
B 1 145 PHE 145 145 145 PHE PHE A . n 
B 1 146 LEU 146 146 146 LEU LEU A . n 
B 1 147 GLU 147 147 147 GLU GLU A . n 
B 1 148 ARG 148 148 148 ARG ARG A . n 
B 1 149 LEU 149 149 149 LEU LEU A . n 
B 1 150 ILE 150 150 150 ILE ILE A . n 
B 1 151 THR 151 151 151 THR THR A . n 
B 1 152 ILE 152 152 152 ILE ILE A . n 
B 1 153 ILE 153 153 153 ILE ILE A . n 
B 1 154 ALA 154 154 154 ALA ALA A . n 
B 1 155 TYR 155 155 155 TYR TYR A . n 
B 1 156 ILE 156 156 156 ILE ILE A . n 
B 1 157 MET 157 157 157 MET MET A . n 
B 1 158 LYS 158 158 158 LYS LYS A . n 
B 1 159 SER 159 159 159 SER SER A . n 
B 1 160 CYS 160 160 160 CYS CYS A . n 
B 1 161 HIS 161 161 161 HIS HIS A . n 
B 1 162 GLN 162 162 162 GLN GLN A . n 
B 1 163 ARG 163 163 163 ARG ARG A . n 
B 1 164 GLN 164 164 164 GLN GLN A . n 
B 1 165 LEU 165 165 165 LEU LEU A . n 
B 1 166 ARG 166 166 166 ARG ARG A . n 
B 1 167 ARG 167 167 167 ARG ARG A . n 
B 1 168 ARG 168 168 ?   ?   ?   A . n 
B 1 169 GLY 169 169 ?   ?   ?   A . n 
B 1 170 ALA 170 170 ?   ?   ?   A . n 
B 1 171 LEU 171 171 ?   ?   ?   A . n 
B 1 172 PRO 172 172 ?   ?   ?   A . n 
B 1 173 GLN 173 173 ?   ?   ?   A . n 
B 1 174 GLU 174 174 ?   ?   ?   A . n 
B 1 175 SER 175 175 ?   ?   ?   A . n 
B 1 176 LEU 176 176 ?   ?   ?   A . n 
B 1 177 LYS 177 177 ?   ?   ?   A . n 
B 1 178 ASP 178 178 ?   ?   ?   A . n 
B 1 179 ALA 179 179 ?   ?   ?   A . n 
B 1 180 GLY 180 180 ?   ?   ?   A . n 
B 1 181 GLN 181 181 ?   ?   ?   A . n 
B 1 182 CYS 182 182 ?   ?   ?   A . n 
B 1 183 GLU 183 183 ?   ?   ?   A . n 
B 1 184 VAL 184 184 ?   ?   ?   A . n 
B 1 185 ASP 185 185 ?   ?   ?   A . n 
B 1 186 SER 186 186 ?   ?   ?   A . n 
B 1 187 LEU 187 187 ?   ?   ?   A . n 
B 1 188 ALA 188 188 188 ALA ALA A . n 
B 1 189 GLY 189 189 189 GLY GLY A . n 
B 1 190 TRP 190 190 190 TRP TRP A . n 
B 1 191 LYS 191 191 191 LYS LYS A . n 
B 1 192 PRO 192 192 192 PRO PRO A . n 
B 1 193 SER 193 193 193 SER SER A . n 
B 1 194 VAL 194 194 194 VAL VAL A . n 
B 1 195 TYR 195 195 195 TYR TYR A . n 
B 1 196 TYR 196 196 196 TYR TYR A . n 
B 1 197 VAL 197 197 197 VAL VAL A . n 
B 1 198 MET 198 198 198 MET MET A . n 
B 1 199 LEU 199 199 199 LEU LEU A . n 
B 1 200 ILE 200 200 200 ILE ILE A . n 
B 1 201 LEU 201 201 201 LEU LEU A . n 
B 1 202 CYS 202 202 202 CYS CYS A . n 
B 1 203 THR 203 203 203 THR THR A . n 
B 1 204 ALA 204 204 204 ALA ALA A . n 
B 1 205 SER 205 205 205 SER SER A . n 
B 1 206 ILE 206 206 206 ILE ILE A . n 
B 1 207 LEU 207 207 207 LEU LEU A . n 
B 1 208 ILE 208 208 208 ILE ILE A . n 
B 1 209 SER 209 209 209 SER SER A . n 
B 1 210 CYS 210 210 210 CYS CYS A . n 
B 1 211 CYS 211 211 211 CYS CYS A . n 
B 1 212 ALA 212 212 212 ALA ALA A . n 
B 1 213 SER 213 213 213 SER SER A . n 
B 1 214 ALA 214 214 214 ALA ALA A . n 
B 1 215 MET 215 215 215 MET MET A . n 
B 1 216 TYR 216 216 216 TYR TYR A . n 
B 1 217 THR 217 217 217 THR THR A . n 
B 1 218 PRO 218 218 218 PRO PRO A . n 
B 1 219 ILE 219 219 219 ILE ILE A . n 
B 1 220 GLU 220 220 220 GLU GLU A . n 
B 1 221 GLY 221 221 221 GLY GLY A . n 
B 1 222 TRP 222 222 222 TRP TRP A . n 
B 1 223 SER 223 223 223 SER SER A . n 
B 1 224 TYR 224 224 224 TYR TYR A . n 
B 1 225 PHE 225 225 225 PHE PHE A . n 
B 1 226 ASP 226 226 226 ASP ASP A . n 
B 1 227 SER 227 227 227 SER SER A . n 
B 1 228 LEU 228 228 228 LEU LEU A . n 
B 1 229 TYR 229 229 229 TYR TYR A . n 
B 1 230 PHE 230 230 230 PHE PHE A . n 
B 1 231 CYS 231 231 231 CYS CYS A . n 
B 1 232 PHE 232 232 232 PHE PHE A . n 
B 1 233 VAL 233 233 233 VAL VAL A . n 
B 1 234 ALA 234 234 234 ALA ALA A . n 
B 1 235 PHE 235 235 235 PHE PHE A . n 
B 1 236 SER 236 236 236 SER SER A . n 
B 1 237 THR 237 237 237 THR THR A . n 
B 1 238 ILE 238 238 238 ILE ILE A . n 
B 1 239 GLY 239 239 239 GLY GLY A . n 
B 1 240 PHE 240 240 240 PHE PHE A . n 
B 1 241 GLY 241 241 241 GLY GLY A . n 
B 1 242 ASP 242 242 242 ASP ASP A . n 
B 1 243 LEU 243 243 243 LEU LEU A . n 
B 1 244 VAL 244 244 244 VAL VAL A . n 
B 1 245 SER 245 245 245 SER SER A . n 
B 1 246 SER 246 246 246 SER SER A . n 
B 1 247 GLN 247 247 247 GLN GLN A . n 
B 1 248 ASN 248 248 248 ASN ASN A . n 
B 1 249 ALA 249 249 249 ALA ALA A . n 
B 1 250 HIS 250 250 250 HIS HIS A . n 
B 1 251 TYR 251 251 251 TYR TYR A . n 
B 1 252 GLU 252 252 252 GLU GLU A . n 
B 1 253 SER 253 253 253 SER SER A . n 
B 1 254 GLN 254 254 254 GLN GLN A . n 
B 1 255 GLY 255 255 255 GLY GLY A . n 
B 1 256 LEU 256 256 256 LEU LEU A . n 
B 1 257 TYR 257 257 257 TYR TYR A . n 
B 1 258 ARG 258 258 258 ARG ARG A . n 
B 1 259 PHE 259 259 259 PHE PHE A . n 
B 1 260 ALA 260 260 260 ALA ALA A . n 
B 1 261 ASN 261 261 261 ASN ASN A . n 
B 1 262 PHE 262 262 262 PHE PHE A . n 
B 1 263 VAL 263 263 263 VAL VAL A . n 
B 1 264 PHE 264 264 264 PHE PHE A . n 
B 1 265 ILE 265 265 265 ILE ILE A . n 
B 1 266 LEU 266 266 266 LEU LEU A . n 
B 1 267 MET 267 267 267 MET MET A . n 
B 1 268 GLY 268 268 268 GLY GLY A . n 
B 1 269 VAL 269 269 269 VAL VAL A . n 
B 1 270 CYS 270 270 270 CYS CYS A . n 
B 1 271 CYS 271 271 271 CYS CYS A . n 
B 1 272 ILE 272 272 272 ILE ILE A . n 
B 1 273 TYR 273 273 273 TYR TYR A . n 
B 1 274 SER 274 274 274 SER SER A . n 
B 1 275 LEU 275 275 275 LEU LEU A . n 
B 1 276 PHE 276 276 276 PHE PHE A . n 
B 1 277 ASN 277 277 277 ASN ASN A . n 
B 1 278 VAL 278 278 278 VAL VAL A . n 
B 1 279 ILE 279 279 279 ILE ILE A . n 
B 1 280 SER 280 280 280 SER SER A . n 
B 1 281 ILE 281 281 281 ILE ILE A . n 
B 1 282 LEU 282 282 282 LEU LEU A . n 
B 1 283 ILE 283 283 283 ILE ILE A . n 
B 1 284 LYS 284 284 284 LYS LYS A . n 
B 1 285 GLN 285 285 285 GLN GLN A . n 
B 1 286 SER 286 286 286 SER SER A . n 
B 1 287 LEU 287 287 287 LEU LEU A . n 
B 1 288 ASN 288 288 288 ASN ASN A . n 
B 1 289 TRP 289 289 289 TRP TRP A . n 
B 1 290 ILE 290 290 290 ILE ILE A . n 
B 1 291 LEU 291 291 291 LEU LEU A . n 
B 1 292 ARG 292 292 292 ARG ARG A . n 
B 1 293 LYS 293 293 293 LYS LYS A . n 
B 1 294 MET 294 294 294 MET MET A . n 
B 1 295 ASP 295 295 295 ASP ASP A . n 
B 1 296 SER 296 296 ?   ?   ?   A . n 
B 1 297 GLY 297 297 ?   ?   ?   A . n 
B 1 298 CYS 298 298 ?   ?   ?   A . n 
B 1 299 CYS 299 299 ?   ?   ?   A . n 
B 1 300 PRO 300 300 ?   ?   ?   A . n 
B 1 301 GLN 301 301 ?   ?   ?   A . n 
B 1 302 CYS 302 302 ?   ?   ?   A . n 
B 1 303 GLN 303 303 ?   ?   ?   A . n 
B 1 304 ARG 304 304 ?   ?   ?   A . n 
B 1 305 GLY 305 305 ?   ?   ?   A . n 
B 1 306 LEU 306 306 ?   ?   ?   A . n 
B 1 307 LEU 307 307 ?   ?   ?   A . n 
B 1 308 ARG 308 308 ?   ?   ?   A . n 
B 1 309 SER 309 309 ?   ?   ?   A . n 
B 1 310 ARG 310 310 ?   ?   ?   A . n 
B 1 311 ARG 311 311 ?   ?   ?   A . n 
B 1 312 ASN 312 312 ?   ?   ?   A . n 
B 1 313 VAL 313 313 ?   ?   ?   A . n 
B 1 314 VAL 314 314 ?   ?   ?   A . n 
B 1 315 MET 315 315 ?   ?   ?   A . n 
B 1 316 PRO 316 316 ?   ?   ?   A . n 
B 1 317 GLY 317 317 ?   ?   ?   A . n 
B 1 318 SER 318 318 ?   ?   ?   A . n 
B 1 319 VAL 319 319 ?   ?   ?   A . n 
B 1 320 ARG 320 320 ?   ?   ?   A . n 
B 1 321 ASN 321 321 ?   ?   ?   A . n 
B 1 322 ARG 322 322 ?   ?   ?   A . n 
B 1 323 CYS 323 323 ?   ?   ?   A . n 
B 1 324 ASN 324 324 ?   ?   ?   A . n 
B 1 325 ILE 325 325 ?   ?   ?   A . n 
B 1 326 SER 326 326 ?   ?   ?   A . n 
B 1 327 ILE 327 327 ?   ?   ?   A . n 
B 1 328 GLU 328 328 ?   ?   ?   A . n 
B 1 329 THR 329 329 ?   ?   ?   A . n 
B 1 330 ASP 330 330 ?   ?   ?   A . n 
B 1 331 GLY 331 331 ?   ?   ?   A . n 
B 1 332 VAL 332 332 ?   ?   ?   A . n 
B 1 333 ALA 333 333 ?   ?   ?   A . n 
B 1 334 GLU 334 334 ?   ?   ?   A . n 
B 1 335 SER 335 335 ?   ?   ?   A . n 
B 1 336 ASP 336 336 ?   ?   ?   A . n 
B 1 337 THR 337 337 ?   ?   ?   A . n 
B 1 338 ASP 338 338 ?   ?   ?   A . n 
B 1 339 GLY 339 339 ?   ?   ?   A . n 
B 1 340 ARG 340 340 ?   ?   ?   A . n 
B 1 341 ARG 341 341 ?   ?   ?   A . n 
B 1 342 LEU 342 342 ?   ?   ?   A . n 
B 1 343 SER 343 343 ?   ?   ?   A . n 
B 1 344 GLY 344 344 ?   ?   ?   A . n 
B 1 345 GLU 345 345 ?   ?   ?   A . n 
B 1 346 MET 346 346 ?   ?   ?   A . n 
B 1 347 ILE 347 347 ?   ?   ?   A . n 
B 1 348 SER 348 348 ?   ?   ?   A . n 
B 1 349 MET 349 349 ?   ?   ?   A . n 
B 1 350 LYS 350 350 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        EIC 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   EIC 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C  2 D12 1 401 302 D12 D12 U . 
D  2 D12 1 402 303 D12 D12 U . 
E  3 OCT 1 403 305 OCT D08 U . 
F  3 OCT 1 404 306 OCT D08 U . 
G  2 D12 1 405 307 D12 D12 U . 
H  4 HEX 1 406 308 HEX D06 U . 
I  3 OCT 1 407 309 OCT D08 U . 
J  4 HEX 1 408 311 HEX D06 U . 
K  4 HEX 1 409 313 HEX D06 U . 
L  4 HEX 1 410 317 HEX D06 U . 
M  4 HEX 1 411 318 HEX D06 U . 
N  4 HEX 1 412 319 HEX D06 U . 
O  4 HEX 1 413 320 HEX D06 U . 
P  5 EIC 1 414 321 EIC EIC U . 
Q  2 D12 1 415 303 D12 D12 U . 
R  3 OCT 1 416 304 OCT D08 U . 
S  4 HEX 1 417 2   HEX D06 U . 
T  3 OCT 1 401 304 OCT D08 A . 
U  4 HEX 1 402 310 HEX D06 A . 
V  6 R16 1 403 322 R16 D16 A . 
W  2 D12 1 404 302 D12 D12 A . 
X  3 OCT 1 405 305 OCT D08 A . 
Y  3 OCT 1 406 306 OCT D08 A . 
Z  2 D12 1 407 307 D12 D12 A . 
AA 4 HEX 1 408 308 HEX D06 A . 
BA 3 OCT 1 409 309 OCT D08 A . 
CA 4 HEX 1 410 311 HEX D06 A . 
DA 4 HEX 1 411 314 HEX D06 A . 
EA 4 HEX 1 412 316 HEX D06 A . 
FA 4 HEX 1 413 317 HEX D06 A . 
GA 5 EIC 1 414 318 EIC EIC A . 
HA 6 R16 1 415 319 R16 D16 A . 
IA 7 K   1 416 3   K   K   A . 
JA 7 K   1 417 4   K   K   A . 
KA 7 K   1 418 5   K   K   A . 
LA 7 K   1 419 6   K   K   A . 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9C07 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9C07 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9C07 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9C07 
_struct.title                        'Structure of K2P13.1 (THIK1) S136P in detergent' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9C07 
_struct_keywords.text            'Potassium channel, K2P channel, Transport protein' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A  N N 1 ? 
B  N N 1 ? 
C  N N 2 ? 
D  N N 2 ? 
E  N N 3 ? 
F  N N 3 ? 
G  N N 2 ? 
H  N N 4 ? 
I  N N 3 ? 
J  N N 4 ? 
K  N N 4 ? 
L  N N 4 ? 
M  N N 4 ? 
N  N N 4 ? 
O  N N 4 ? 
P  N N 5 ? 
Q  N N 2 ? 
R  N N 3 ? 
S  N N 4 ? 
T  N N 3 ? 
U  N N 4 ? 
V  N N 6 ? 
W  N N 2 ? 
X  N N 3 ? 
Y  N N 3 ? 
Z  N N 2 ? 
AA N N 4 ? 
BA N N 3 ? 
CA N N 4 ? 
DA N N 4 ? 
EA N N 4 ? 
FA N N 4 ? 
GA N N 5 ? 
HA N N 6 ? 
IA N N 7 ? 
JA N N 7 ? 
KA N N 7 ? 
LA N N 7 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    KCNKD_HUMAN 
_struct_ref.pdbx_db_accession          Q9HB14 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEE
ATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGF
GDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVR
NRCNISIETDGVAESDTDGRRLSGEMISMK
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9C07 U 1 ? 350 ? Q9HB14 1 ? 350 ? 1 350 
2 1 9C07 A 1 ? 350 ? Q9HB14 1 ? 350 ? 1 350 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9C07 GLN U 59  ? UNP Q9HB14 ASN 59  'engineered mutation' 59  1 
1 9C07 GLN U 65  ? UNP Q9HB14 ASN 65  'engineered mutation' 65  2 
1 9C07 PRO U 136 ? UNP Q9HB14 SER 136 'engineered mutation' 136 3 
2 9C07 GLN A 59  ? UNP Q9HB14 ASN 59  'engineered mutation' 59  4 
2 9C07 GLN A 65  ? UNP Q9HB14 ASN 65  'engineered mutation' 65  5 
2 9C07 PRO A 136 ? UNP Q9HB14 SER 136 'engineered mutation' 136 6 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,AA,BA,CA,DA,EA,FA,GA,HA,IA,JA,KA,LA 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 14  ? GLN A 65  ? ASN U 14  GLN U 65  1 ? 52 
HELX_P HELX_P2  AA2 SER A 67  ? ARG A 83  ? SER U 67  ARG U 83  1 ? 17 
HELX_P HELX_P3  AA3 PHE A 97  ? SER A 109 ? PHE U 97  SER U 109 1 ? 13 
HELX_P HELX_P4  AA4 LYS A 124 ? ARG A 166 ? LYS U 124 ARG U 166 1 ? 43 
HELX_P HELX_P5  AA5 SER A 193 ? MET A 215 ? SER U 193 MET U 215 1 ? 23 
HELX_P HELX_P6  AA6 SER A 223 ? SER A 236 ? SER U 223 SER U 236 1 ? 14 
HELX_P HELX_P7  AA7 GLY A 255 ? ASP A 295 ? GLY U 255 ASP U 295 1 ? 41 
HELX_P HELX_P8  AA8 GLU B 15  ? HIS B 64  ? GLU A 15  HIS A 64  1 ? 50 
HELX_P HELX_P9  AA9 SER B 67  ? GLY B 85  ? SER A 67  GLY A 85  1 ? 19 
HELX_P HELX_P10 AB1 ASP B 96  ? SER B 109 ? ASP A 96  SER A 109 1 ? 14 
HELX_P HELX_P11 AB2 LYS B 124 ? ARG B 166 ? LYS A 124 ARG A 166 1 ? 43 
HELX_P HELX_P12 AB3 SER B 193 ? GLU B 220 ? SER A 193 GLU A 220 1 ? 28 
HELX_P HELX_P13 AB4 SER B 223 ? SER B 236 ? SER A 223 SER A 236 1 ? 14 
HELX_P HELX_P14 AB5 GLY B 255 ? MET B 294 ? GLY A 255 MET A 294 1 ? 40 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A THR 110 O ? ? ? 1_555 IA K . K ? ? U THR 110 A K 416 1_555 ? ? ? ? ? ? ? 2.860 ? ? 
metalc2  metalc ? ? A THR 110 O ? ? ? 1_555 LA K . K ? ? U THR 110 A K 419 1_555 ? ? ? ? ? ? ? 2.698 ? ? 
metalc3  metalc ? ? A ILE 111 O ? ? ? 1_555 KA K . K ? ? U ILE 111 A K 418 1_555 ? ? ? ? ? ? ? 2.625 ? ? 
metalc4  metalc ? ? A ILE 111 O ? ? ? 1_555 LA K . K ? ? U ILE 111 A K 419 1_555 ? ? ? ? ? ? ? 3.159 ? ? 
metalc5  metalc ? ? A GLY 112 O ? ? ? 1_555 JA K . K ? ? U GLY 112 A K 417 1_555 ? ? ? ? ? ? ? 2.743 ? ? 
metalc6  metalc ? ? A GLY 112 O ? ? ? 1_555 KA K . K ? ? U GLY 112 A K 418 1_555 ? ? ? ? ? ? ? 3.064 ? ? 
metalc7  metalc ? ? A PHE 113 O ? ? ? 1_555 JA K . K ? ? U PHE 113 A K 417 1_555 ? ? ? ? ? ? ? 3.331 ? ? 
metalc8  metalc ? ? A THR 237 O ? ? ? 1_555 IA K . K ? ? U THR 237 A K 416 1_555 ? ? ? ? ? ? ? 2.873 ? ? 
metalc9  metalc ? ? A THR 237 O ? ? ? 1_555 LA K . K ? ? U THR 237 A K 419 1_555 ? ? ? ? ? ? ? 2.517 ? ? 
metalc10 metalc ? ? A ILE 238 O ? ? ? 1_555 KA K . K ? ? U ILE 238 A K 418 1_555 ? ? ? ? ? ? ? 2.582 ? ? 
metalc11 metalc ? ? A ILE 238 O ? ? ? 1_555 LA K . K ? ? U ILE 238 A K 419 1_555 ? ? ? ? ? ? ? 3.274 ? ? 
metalc12 metalc ? ? A GLY 239 O ? ? ? 1_555 JA K . K ? ? U GLY 239 A K 417 1_555 ? ? ? ? ? ? ? 2.700 ? ? 
metalc13 metalc ? ? A GLY 239 O ? ? ? 1_555 KA K . K ? ? U GLY 239 A K 418 1_555 ? ? ? ? ? ? ? 3.298 ? ? 
metalc14 metalc ? ? A PHE 240 O ? ? ? 1_555 JA K . K ? ? U PHE 240 A K 417 1_555 ? ? ? ? ? ? ? 3.362 ? ? 
metalc15 metalc ? ? B THR 110 O ? ? ? 1_555 IA K . K ? ? A THR 110 A K 416 1_555 ? ? ? ? ? ? ? 2.861 ? ? 
metalc16 metalc ? ? B THR 110 O ? ? ? 1_555 LA K . K ? ? A THR 110 A K 419 1_555 ? ? ? ? ? ? ? 2.603 ? ? 
metalc17 metalc ? ? B ILE 111 O ? ? ? 1_555 KA K . K ? ? A ILE 111 A K 418 1_555 ? ? ? ? ? ? ? 2.619 ? ? 
metalc18 metalc ? ? B ILE 111 O ? ? ? 1_555 LA K . K ? ? A ILE 111 A K 419 1_555 ? ? ? ? ? ? ? 3.174 ? ? 
metalc19 metalc ? ? B GLY 112 O ? ? ? 1_555 JA K . K ? ? A GLY 112 A K 417 1_555 ? ? ? ? ? ? ? 2.774 ? ? 
metalc20 metalc ? ? B GLY 112 O ? ? ? 1_555 KA K . K ? ? A GLY 112 A K 418 1_555 ? ? ? ? ? ? ? 3.166 ? ? 
metalc21 metalc ? ? B PHE 113 O ? ? ? 1_555 JA K . K ? ? A PHE 113 A K 417 1_555 ? ? ? ? ? ? ? 3.308 ? ? 
metalc22 metalc ? ? B THR 237 O ? ? ? 1_555 IA K . K ? ? A THR 237 A K 416 1_555 ? ? ? ? ? ? ? 2.821 ? ? 
metalc23 metalc ? ? B THR 237 O ? ? ? 1_555 LA K . K ? ? A THR 237 A K 419 1_555 ? ? ? ? ? ? ? 2.643 ? ? 
metalc24 metalc ? ? B ILE 238 O ? ? ? 1_555 KA K . K ? ? A ILE 238 A K 418 1_555 ? ? ? ? ? ? ? 2.605 ? ? 
metalc25 metalc ? ? B ILE 238 O ? ? ? 1_555 LA K . K ? ? A ILE 238 A K 419 1_555 ? ? ? ? ? ? ? 3.335 ? ? 
metalc26 metalc ? ? B GLY 239 O ? ? ? 1_555 JA K . K ? ? A GLY 239 A K 417 1_555 ? ? ? ? ? ? ? 2.766 ? ? 
metalc27 metalc ? ? B GLY 239 O ? ? ? 1_555 KA K . K ? ? A GLY 239 A K 418 1_555 ? ? ? ? ? ? ? 3.392 ? ? 
metalc28 metalc ? ? B PHE 240 O ? ? ? 1_555 JA K . K ? ? A PHE 240 A K 417 1_555 ? ? ? ? ? ? ? 3.392 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O ? A THR 110 ? U THR 110 ? 1_555 K ? IA K . ? A K 416 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 73.7  ? 
2  O ? A THR 110 ? U THR 110 ? 1_555 K ? IA K . ? A K 416 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 111.9 ? 
3  O ? A THR 237 ? U THR 237 ? 1_555 K ? IA K . ? A K 416 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 68.2  ? 
4  O ? A THR 110 ? U THR 110 ? 1_555 K ? IA K . ? A K 416 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 68.2  ? 
5  O ? A THR 237 ? U THR 237 ? 1_555 K ? IA K . ? A K 416 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 109.0 ? 
6  O ? B THR 110 ? A THR 110 ? 1_555 K ? IA K . ? A K 416 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 73.9  ? 
7  O ? A THR 110 ? U THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? A ILE 111 ? U ILE 111 ? 1_555 71.7  ? 
8  O ? A THR 110 ? U THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 82.4  ? 
9  O ? A ILE 111 ? U ILE 111 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? A THR 237 ? U THR 237 ? 1_555 89.5  ? 
10 O ? A THR 110 ? U THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 131.2 ? 
11 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 66.8  ? 
12 O ? A THR 237 ? U THR 237 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 72.9  ? 
13 O ? A THR 110 ? U THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 126.8 ? 
14 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 154.7 ? 
15 O ? A THR 237 ? U THR 237 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 77.7  ? 
16 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 110 ? A THR 110 ? 1_555 88.4  ? 
17 O ? A THR 110 ? U THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 150.6 ? 
18 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 101.0 ? 
19 O ? A THR 237 ? U THR 237 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 126.6 ? 
20 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 64.4  ? 
21 O ? B THR 110 ? A THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 70.9  ? 
22 O ? A THR 110 ? U THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 73.2  ? 
23 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 123.2 ? 
24 O ? A THR 237 ? U THR 237 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 127.9 ? 
25 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 153.2 ? 
26 O ? B THR 110 ? A THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 81.3  ? 
27 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B THR 237 ? A THR 237 ? 1_555 88.9  ? 
28 O ? A THR 110 ? U THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 86.7  ? 
29 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 64.0  ? 
30 O ? A THR 237 ? U THR 237 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 153.4 ? 
31 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 97.0  ? 
32 O ? B THR 110 ? A THR 110 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 127.5 ? 
33 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 65.2  ? 
34 O ? B THR 237 ? A THR 237 ? 1_555 K ? LA K . ? A K 419 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 70.8  ? 
35 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? A GLY 112 ? U GLY 112 ? 1_555 65.0  ? 
36 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 85.8  ? 
37 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? A ILE 238 ? U ILE 238 ? 1_555 121.4 ? 
38 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 85.2  ? 
39 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 62.9  ? 
40 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 65.1  ? 
41 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 137.6 ? 
42 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 151.6 ? 
43 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 82.7  ? 
44 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 111 ? A ILE 111 ? 1_555 125.1 ? 
45 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 149.7 ? 
46 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 101.0 ? 
47 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 79.3  ? 
48 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 64.7  ? 
49 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 66.5  ? 
50 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 82.4  ? 
51 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 82.3  ? 
52 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 145.3 ? 
53 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 145.2 ? 
54 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 84.4  ? 
55 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B ILE 238 ? A ILE 238 ? 1_555 123.9 ? 
56 O ? A ILE 111 ? U ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 125.3 ? 
57 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 67.7  ? 
58 O ? A ILE 238 ? U ILE 238 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 143.8 ? 
59 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 96.6  ? 
60 O ? B ILE 111 ? A ILE 111 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 84.0  ? 
61 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 64.6  ? 
62 O ? B ILE 238 ? A ILE 238 ? 1_555 K ? KA K . ? A K 418 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 65.5  ? 
63 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? A PHE 113 ? U PHE 113 ? 1_555 67.3  ? 
64 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 75.4  ? 
65 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? A GLY 239 ? U GLY 239 ? 1_555 82.3  ? 
66 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 123.8 ? 
67 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 69.5  ? 
68 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? A PHE 240 ? U PHE 240 ? 1_555 64.8  ? 
69 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 121.2 ? 
70 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 155.3 ? 
71 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 78.4  ? 
72 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 112 ? A GLY 112 ? 1_555 88.3  ? 
73 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 158.0 ? 
74 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 114.9 ? 
75 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 126.3 ? 
76 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 74.5  ? 
77 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 113 ? A PHE 113 ? 1_555 66.7  ? 
78 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 81.8  ? 
79 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 126.0 ? 
80 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 132.1 ? 
81 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 154.3 ? 
82 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 78.6  ? 
83 O ? B PHE 113 ? A PHE 113 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B GLY 239 ? A GLY 239 ? 1_555 80.0  ? 
84 O ? A GLY 112 ? U GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 91.4  ? 
85 O ? A PHE 113 ? U PHE 113 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 74.2  ? 
86 O ? A GLY 239 ? U GLY 239 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 156.1 ? 
87 O ? A PHE 240 ? U PHE 240 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 109.4 ? 
88 O ? B GLY 112 ? A GLY 112 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 125.5 ? 
89 O ? B PHE 113 ? A PHE 113 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 69.4  ? 
90 O ? B GLY 239 ? A GLY 239 ? 1_555 K ? JA K . ? A K 417 ? 1_555 O ? B PHE 240 ? A PHE 240 ? 1_555 63.2  ? 
# 
_pdbx_entry_details.entry_id                   9C07 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP U 96  ? ? -82.38  -73.48  
2  1 PHE U 97  ? ? -143.74 -25.08  
3  1 TYR U 216 ? ? 76.70   -12.17  
4  1 ASN U 248 ? ? -142.56 29.15   
5  1 ALA U 249 ? ? 59.12   -120.86 
6  1 GLU U 252 ? ? 58.35   -126.73 
7  1 GLN U 254 ? ? 67.06   -6.94   
8  1 ASN A 90  ? ? 36.57   59.75   
9  1 ALA A 249 ? ? 51.47   -114.26 
10 1 GLU A 252 ? ? 54.77   -124.94 
11 1 GLN A 254 ? ? 72.72   -7.97   
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9C07 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9C07 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.73 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               508529 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.8 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'homodimer of K2P13.1 (THIK1) S136P mutant' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9C07 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           'FEI TITAN KRIOS AUTOGRID HOLDER' 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         NITROGEN 
# 
_em_sample_support.id               1 
_em_sample_support.film_material    ? 
_em_sample_support.method           ? 
_em_sample_support.grid_material    GOLD 
_em_sample_support.grid_mesh_size   300 
_em_sample_support.grid_type        'Quantifoil R1.2/1.3' 
_em_sample_support.details          ? 
_em_sample_support.specimen_id      1 
_em_sample_support.citation_id      ? 
# 
_em_vitrification.entry_id              9C07 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              100 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   277.15 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9C07 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
_em_single_particle_entity.entry_id              9C07 
_em_single_particle_entity.id                    1 
_em_single_particle_entity.image_processing_id   1 
_em_single_particle_entity.point_symmetry        C2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 U MET 1   ? A MET 1   
2   1 Y 1 U ALA 2   ? A ALA 2   
3   1 Y 1 U GLY 3   ? A GLY 3   
4   1 Y 1 U ARG 4   ? A ARG 4   
5   1 Y 1 U GLY 5   ? A GLY 5   
6   1 Y 1 U PHE 6   ? A PHE 6   
7   1 Y 1 U SER 7   ? A SER 7   
8   1 Y 1 U TRP 8   ? A TRP 8   
9   1 Y 1 U GLY 9   ? A GLY 9   
10  1 Y 1 U PRO 10  ? A PRO 10  
11  1 Y 1 U GLY 11  ? A GLY 11  
12  1 Y 1 U HIS 12  ? A HIS 12  
13  1 Y 1 U LEU 13  ? A LEU 13  
14  1 Y 1 U ARG 168 ? A ARG 168 
15  1 Y 1 U GLY 169 ? A GLY 169 
16  1 Y 1 U ALA 170 ? A ALA 170 
17  1 Y 1 U LEU 171 ? A LEU 171 
18  1 Y 1 U PRO 172 ? A PRO 172 
19  1 Y 1 U GLN 173 ? A GLN 173 
20  1 Y 1 U GLU 174 ? A GLU 174 
21  1 Y 1 U SER 175 ? A SER 175 
22  1 Y 1 U LEU 176 ? A LEU 176 
23  1 Y 1 U LYS 177 ? A LYS 177 
24  1 Y 1 U ASP 178 ? A ASP 178 
25  1 Y 1 U ALA 179 ? A ALA 179 
26  1 Y 1 U GLY 180 ? A GLY 180 
27  1 Y 1 U GLN 181 ? A GLN 181 
28  1 Y 1 U CYS 182 ? A CYS 182 
29  1 Y 1 U GLU 183 ? A GLU 183 
30  1 Y 1 U VAL 184 ? A VAL 184 
31  1 Y 1 U ASP 185 ? A ASP 185 
32  1 Y 1 U SER 186 ? A SER 186 
33  1 Y 1 U LEU 187 ? A LEU 187 
34  1 Y 1 U SER 296 ? A SER 296 
35  1 Y 1 U GLY 297 ? A GLY 297 
36  1 Y 1 U CYS 298 ? A CYS 298 
37  1 Y 1 U CYS 299 ? A CYS 299 
38  1 Y 1 U PRO 300 ? A PRO 300 
39  1 Y 1 U GLN 301 ? A GLN 301 
40  1 Y 1 U CYS 302 ? A CYS 302 
41  1 Y 1 U GLN 303 ? A GLN 303 
42  1 Y 1 U ARG 304 ? A ARG 304 
43  1 Y 1 U GLY 305 ? A GLY 305 
44  1 Y 1 U LEU 306 ? A LEU 306 
45  1 Y 1 U LEU 307 ? A LEU 307 
46  1 Y 1 U ARG 308 ? A ARG 308 
47  1 Y 1 U SER 309 ? A SER 309 
48  1 Y 1 U ARG 310 ? A ARG 310 
49  1 Y 1 U ARG 311 ? A ARG 311 
50  1 Y 1 U ASN 312 ? A ASN 312 
51  1 Y 1 U VAL 313 ? A VAL 313 
52  1 Y 1 U VAL 314 ? A VAL 314 
53  1 Y 1 U MET 315 ? A MET 315 
54  1 Y 1 U PRO 316 ? A PRO 316 
55  1 Y 1 U GLY 317 ? A GLY 317 
56  1 Y 1 U SER 318 ? A SER 318 
57  1 Y 1 U VAL 319 ? A VAL 319 
58  1 Y 1 U ARG 320 ? A ARG 320 
59  1 Y 1 U ASN 321 ? A ASN 321 
60  1 Y 1 U ARG 322 ? A ARG 322 
61  1 Y 1 U CYS 323 ? A CYS 323 
62  1 Y 1 U ASN 324 ? A ASN 324 
63  1 Y 1 U ILE 325 ? A ILE 325 
64  1 Y 1 U SER 326 ? A SER 326 
65  1 Y 1 U ILE 327 ? A ILE 327 
66  1 Y 1 U GLU 328 ? A GLU 328 
67  1 Y 1 U THR 329 ? A THR 329 
68  1 Y 1 U ASP 330 ? A ASP 330 
69  1 Y 1 U GLY 331 ? A GLY 331 
70  1 Y 1 U VAL 332 ? A VAL 332 
71  1 Y 1 U ALA 333 ? A ALA 333 
72  1 Y 1 U GLU 334 ? A GLU 334 
73  1 Y 1 U SER 335 ? A SER 335 
74  1 Y 1 U ASP 336 ? A ASP 336 
75  1 Y 1 U THR 337 ? A THR 337 
76  1 Y 1 U ASP 338 ? A ASP 338 
77  1 Y 1 U GLY 339 ? A GLY 339 
78  1 Y 1 U ARG 340 ? A ARG 340 
79  1 Y 1 U ARG 341 ? A ARG 341 
80  1 Y 1 U LEU 342 ? A LEU 342 
81  1 Y 1 U SER 343 ? A SER 343 
82  1 Y 1 U GLY 344 ? A GLY 344 
83  1 Y 1 U GLU 345 ? A GLU 345 
84  1 Y 1 U MET 346 ? A MET 346 
85  1 Y 1 U ILE 347 ? A ILE 347 
86  1 Y 1 U SER 348 ? A SER 348 
87  1 Y 1 U MET 349 ? A MET 349 
88  1 Y 1 U LYS 350 ? A LYS 350 
89  1 Y 1 A MET 1   ? B MET 1   
90  1 Y 1 A ALA 2   ? B ALA 2   
91  1 Y 1 A GLY 3   ? B GLY 3   
92  1 Y 1 A ARG 4   ? B ARG 4   
93  1 Y 1 A GLY 5   ? B GLY 5   
94  1 Y 1 A PHE 6   ? B PHE 6   
95  1 Y 1 A SER 7   ? B SER 7   
96  1 Y 1 A TRP 8   ? B TRP 8   
97  1 Y 1 A GLY 9   ? B GLY 9   
98  1 Y 1 A PRO 10  ? B PRO 10  
99  1 Y 1 A GLY 11  ? B GLY 11  
100 1 Y 1 A HIS 12  ? B HIS 12  
101 1 Y 1 A LEU 13  ? B LEU 13  
102 1 Y 1 A ARG 168 ? B ARG 168 
103 1 Y 1 A GLY 169 ? B GLY 169 
104 1 Y 1 A ALA 170 ? B ALA 170 
105 1 Y 1 A LEU 171 ? B LEU 171 
106 1 Y 1 A PRO 172 ? B PRO 172 
107 1 Y 1 A GLN 173 ? B GLN 173 
108 1 Y 1 A GLU 174 ? B GLU 174 
109 1 Y 1 A SER 175 ? B SER 175 
110 1 Y 1 A LEU 176 ? B LEU 176 
111 1 Y 1 A LYS 177 ? B LYS 177 
112 1 Y 1 A ASP 178 ? B ASP 178 
113 1 Y 1 A ALA 179 ? B ALA 179 
114 1 Y 1 A GLY 180 ? B GLY 180 
115 1 Y 1 A GLN 181 ? B GLN 181 
116 1 Y 1 A CYS 182 ? B CYS 182 
117 1 Y 1 A GLU 183 ? B GLU 183 
118 1 Y 1 A VAL 184 ? B VAL 184 
119 1 Y 1 A ASP 185 ? B ASP 185 
120 1 Y 1 A SER 186 ? B SER 186 
121 1 Y 1 A LEU 187 ? B LEU 187 
122 1 Y 1 A SER 296 ? B SER 296 
123 1 Y 1 A GLY 297 ? B GLY 297 
124 1 Y 1 A CYS 298 ? B CYS 298 
125 1 Y 1 A CYS 299 ? B CYS 299 
126 1 Y 1 A PRO 300 ? B PRO 300 
127 1 Y 1 A GLN 301 ? B GLN 301 
128 1 Y 1 A CYS 302 ? B CYS 302 
129 1 Y 1 A GLN 303 ? B GLN 303 
130 1 Y 1 A ARG 304 ? B ARG 304 
131 1 Y 1 A GLY 305 ? B GLY 305 
132 1 Y 1 A LEU 306 ? B LEU 306 
133 1 Y 1 A LEU 307 ? B LEU 307 
134 1 Y 1 A ARG 308 ? B ARG 308 
135 1 Y 1 A SER 309 ? B SER 309 
136 1 Y 1 A ARG 310 ? B ARG 310 
137 1 Y 1 A ARG 311 ? B ARG 311 
138 1 Y 1 A ASN 312 ? B ASN 312 
139 1 Y 1 A VAL 313 ? B VAL 313 
140 1 Y 1 A VAL 314 ? B VAL 314 
141 1 Y 1 A MET 315 ? B MET 315 
142 1 Y 1 A PRO 316 ? B PRO 316 
143 1 Y 1 A GLY 317 ? B GLY 317 
144 1 Y 1 A SER 318 ? B SER 318 
145 1 Y 1 A VAL 319 ? B VAL 319 
146 1 Y 1 A ARG 320 ? B ARG 320 
147 1 Y 1 A ASN 321 ? B ASN 321 
148 1 Y 1 A ARG 322 ? B ARG 322 
149 1 Y 1 A CYS 323 ? B CYS 323 
150 1 Y 1 A ASN 324 ? B ASN 324 
151 1 Y 1 A ILE 325 ? B ILE 325 
152 1 Y 1 A SER 326 ? B SER 326 
153 1 Y 1 A ILE 327 ? B ILE 327 
154 1 Y 1 A GLU 328 ? B GLU 328 
155 1 Y 1 A THR 329 ? B THR 329 
156 1 Y 1 A ASP 330 ? B ASP 330 
157 1 Y 1 A GLY 331 ? B GLY 331 
158 1 Y 1 A VAL 332 ? B VAL 332 
159 1 Y 1 A ALA 333 ? B ALA 333 
160 1 Y 1 A GLU 334 ? B GLU 334 
161 1 Y 1 A SER 335 ? B SER 335 
162 1 Y 1 A ASP 336 ? B ASP 336 
163 1 Y 1 A THR 337 ? B THR 337 
164 1 Y 1 A ASP 338 ? B ASP 338 
165 1 Y 1 A GLY 339 ? B GLY 339 
166 1 Y 1 A ARG 340 ? B ARG 340 
167 1 Y 1 A ARG 341 ? B ARG 341 
168 1 Y 1 A LEU 342 ? B LEU 342 
169 1 Y 1 A SER 343 ? B SER 343 
170 1 Y 1 A GLY 344 ? B GLY 344 
171 1 Y 1 A GLU 345 ? B GLU 345 
172 1 Y 1 A MET 346 ? B MET 346 
173 1 Y 1 A ILE 347 ? B ILE 347 
174 1 Y 1 A SER 348 ? B SER 348 
175 1 Y 1 A MET 349 ? B MET 349 
176 1 Y 1 A LYS 350 ? B LYS 350 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
D12 C1   C N N 88  
D12 C2   C N N 89  
D12 C3   C N N 90  
D12 C4   C N N 91  
D12 C5   C N N 92  
D12 C6   C N N 93  
D12 C7   C N N 94  
D12 C8   C N N 95  
D12 C9   C N N 96  
D12 C10  C N N 97  
D12 C11  C N N 98  
D12 C12  C N N 99  
D12 H11  H N N 100 
D12 H12  H N N 101 
D12 H13  H N N 102 
D12 H21  H N N 103 
D12 H22  H N N 104 
D12 H31  H N N 105 
D12 H32  H N N 106 
D12 H41  H N N 107 
D12 H42  H N N 108 
D12 H51  H N N 109 
D12 H52  H N N 110 
D12 H61  H N N 111 
D12 H62  H N N 112 
D12 H71  H N N 113 
D12 H72  H N N 114 
D12 H81  H N N 115 
D12 H82  H N N 116 
D12 H91  H N N 117 
D12 H92  H N N 118 
D12 H101 H N N 119 
D12 H102 H N N 120 
D12 H111 H N N 121 
D12 H112 H N N 122 
D12 H121 H N N 123 
D12 H122 H N N 124 
D12 H123 H N N 125 
EIC C1   C N N 126 
EIC C2   C N N 127 
EIC C3   C N N 128 
EIC C4   C N N 129 
EIC C5   C N N 130 
EIC C6   C N N 131 
EIC C7   C N N 132 
EIC C8   C N N 133 
EIC C9   C N N 134 
EIC C10  C N N 135 
EIC C11  C N N 136 
EIC C12  C N N 137 
EIC C13  C N N 138 
EIC C14  C N N 139 
EIC C15  C N N 140 
EIC C16  C N N 141 
EIC C17  C N N 142 
EIC C18  C N N 143 
EIC O1   O N N 144 
EIC O2   O N N 145 
EIC H21  H N N 146 
EIC H22  H N N 147 
EIC H31  H N N 148 
EIC H32  H N N 149 
EIC H41  H N N 150 
EIC H42  H N N 151 
EIC H51  H N N 152 
EIC H52  H N N 153 
EIC H61  H N N 154 
EIC H62  H N N 155 
EIC H71  H N N 156 
EIC H72  H N N 157 
EIC H81  H N N 158 
EIC H82  H N N 159 
EIC H91  H N N 160 
EIC H1O1 H N N 161 
EIC H111 H N N 162 
EIC H112 H N N 163 
EIC H121 H N N 164 
EIC H131 H N N 165 
EIC H141 H N N 166 
EIC H142 H N N 167 
EIC H151 H N N 168 
EIC H152 H N N 169 
EIC H161 H N N 170 
EIC H162 H N N 171 
EIC H171 H N N 172 
EIC H172 H N N 173 
EIC H181 H N N 174 
EIC H182 H N N 175 
EIC H183 H N N 176 
EIC HO2  H N N 177 
GLN N    N N N 178 
GLN CA   C N S 179 
GLN C    C N N 180 
GLN O    O N N 181 
GLN CB   C N N 182 
GLN CG   C N N 183 
GLN CD   C N N 184 
GLN OE1  O N N 185 
GLN NE2  N N N 186 
GLN OXT  O N N 187 
GLN H    H N N 188 
GLN H2   H N N 189 
GLN HA   H N N 190 
GLN HB2  H N N 191 
GLN HB3  H N N 192 
GLN HG2  H N N 193 
GLN HG3  H N N 194 
GLN HE21 H N N 195 
GLN HE22 H N N 196 
GLN HXT  H N N 197 
GLU N    N N N 198 
GLU CA   C N S 199 
GLU C    C N N 200 
GLU O    O N N 201 
GLU CB   C N N 202 
GLU CG   C N N 203 
GLU CD   C N N 204 
GLU OE1  O N N 205 
GLU OE2  O N N 206 
GLU OXT  O N N 207 
GLU H    H N N 208 
GLU H2   H N N 209 
GLU HA   H N N 210 
GLU HB2  H N N 211 
GLU HB3  H N N 212 
GLU HG2  H N N 213 
GLU HG3  H N N 214 
GLU HE2  H N N 215 
GLU HXT  H N N 216 
GLY N    N N N 217 
GLY CA   C N N 218 
GLY C    C N N 219 
GLY O    O N N 220 
GLY OXT  O N N 221 
GLY H    H N N 222 
GLY H2   H N N 223 
GLY HA2  H N N 224 
GLY HA3  H N N 225 
GLY HXT  H N N 226 
HEX C1   C N N 227 
HEX C2   C N N 228 
HEX C3   C N N 229 
HEX C4   C N N 230 
HEX C5   C N N 231 
HEX C6   C N N 232 
HEX H11  H N N 233 
HEX H12  H N N 234 
HEX H13  H N N 235 
HEX H21  H N N 236 
HEX H22  H N N 237 
HEX H31  H N N 238 
HEX H32  H N N 239 
HEX H41  H N N 240 
HEX H42  H N N 241 
HEX H51  H N N 242 
HEX H52  H N N 243 
HEX H61  H N N 244 
HEX H62  H N N 245 
HEX H63  H N N 246 
HIS N    N N N 247 
HIS CA   C N S 248 
HIS C    C N N 249 
HIS O    O N N 250 
HIS CB   C N N 251 
HIS CG   C Y N 252 
HIS ND1  N Y N 253 
HIS CD2  C Y N 254 
HIS CE1  C Y N 255 
HIS NE2  N Y N 256 
HIS OXT  O N N 257 
HIS H    H N N 258 
HIS H2   H N N 259 
HIS HA   H N N 260 
HIS HB2  H N N 261 
HIS HB3  H N N 262 
HIS HD1  H N N 263 
HIS HD2  H N N 264 
HIS HE1  H N N 265 
HIS HE2  H N N 266 
HIS HXT  H N N 267 
ILE N    N N N 268 
ILE CA   C N S 269 
ILE C    C N N 270 
ILE O    O N N 271 
ILE CB   C N S 272 
ILE CG1  C N N 273 
ILE CG2  C N N 274 
ILE CD1  C N N 275 
ILE OXT  O N N 276 
ILE H    H N N 277 
ILE H2   H N N 278 
ILE HA   H N N 279 
ILE HB   H N N 280 
ILE HG12 H N N 281 
ILE HG13 H N N 282 
ILE HG21 H N N 283 
ILE HG22 H N N 284 
ILE HG23 H N N 285 
ILE HD11 H N N 286 
ILE HD12 H N N 287 
ILE HD13 H N N 288 
ILE HXT  H N N 289 
K   K    K N N 290 
LEU N    N N N 291 
LEU CA   C N S 292 
LEU C    C N N 293 
LEU O    O N N 294 
LEU CB   C N N 295 
LEU CG   C N N 296 
LEU CD1  C N N 297 
LEU CD2  C N N 298 
LEU OXT  O N N 299 
LEU H    H N N 300 
LEU H2   H N N 301 
LEU HA   H N N 302 
LEU HB2  H N N 303 
LEU HB3  H N N 304 
LEU HG   H N N 305 
LEU HD11 H N N 306 
LEU HD12 H N N 307 
LEU HD13 H N N 308 
LEU HD21 H N N 309 
LEU HD22 H N N 310 
LEU HD23 H N N 311 
LEU HXT  H N N 312 
LYS N    N N N 313 
LYS CA   C N S 314 
LYS C    C N N 315 
LYS O    O N N 316 
LYS CB   C N N 317 
LYS CG   C N N 318 
LYS CD   C N N 319 
LYS CE   C N N 320 
LYS NZ   N N N 321 
LYS OXT  O N N 322 
LYS H    H N N 323 
LYS H2   H N N 324 
LYS HA   H N N 325 
LYS HB2  H N N 326 
LYS HB3  H N N 327 
LYS HG2  H N N 328 
LYS HG3  H N N 329 
LYS HD2  H N N 330 
LYS HD3  H N N 331 
LYS HE2  H N N 332 
LYS HE3  H N N 333 
LYS HZ1  H N N 334 
LYS HZ2  H N N 335 
LYS HZ3  H N N 336 
LYS HXT  H N N 337 
MET N    N N N 338 
MET CA   C N S 339 
MET C    C N N 340 
MET O    O N N 341 
MET CB   C N N 342 
MET CG   C N N 343 
MET SD   S N N 344 
MET CE   C N N 345 
MET OXT  O N N 346 
MET H    H N N 347 
MET H2   H N N 348 
MET HA   H N N 349 
MET HB2  H N N 350 
MET HB3  H N N 351 
MET HG2  H N N 352 
MET HG3  H N N 353 
MET HE1  H N N 354 
MET HE2  H N N 355 
MET HE3  H N N 356 
MET HXT  H N N 357 
OCT C1   C N N 358 
OCT C2   C N N 359 
OCT C3   C N N 360 
OCT C4   C N N 361 
OCT C5   C N N 362 
OCT C6   C N N 363 
OCT C7   C N N 364 
OCT C8   C N N 365 
OCT H11  H N N 366 
OCT H12  H N N 367 
OCT H13  H N N 368 
OCT H21  H N N 369 
OCT H22  H N N 370 
OCT H31  H N N 371 
OCT H32  H N N 372 
OCT H41  H N N 373 
OCT H42  H N N 374 
OCT H51  H N N 375 
OCT H52  H N N 376 
OCT H61  H N N 377 
OCT H62  H N N 378 
OCT H71  H N N 379 
OCT H72  H N N 380 
OCT H81  H N N 381 
OCT H82  H N N 382 
OCT H83  H N N 383 
PHE N    N N N 384 
PHE CA   C N S 385 
PHE C    C N N 386 
PHE O    O N N 387 
PHE CB   C N N 388 
PHE CG   C Y N 389 
PHE CD1  C Y N 390 
PHE CD2  C Y N 391 
PHE CE1  C Y N 392 
PHE CE2  C Y N 393 
PHE CZ   C Y N 394 
PHE OXT  O N N 395 
PHE H    H N N 396 
PHE H2   H N N 397 
PHE HA   H N N 398 
PHE HB2  H N N 399 
PHE HB3  H N N 400 
PHE HD1  H N N 401 
PHE HD2  H N N 402 
PHE HE1  H N N 403 
PHE HE2  H N N 404 
PHE HZ   H N N 405 
PHE HXT  H N N 406 
PRO N    N N N 407 
PRO CA   C N S 408 
PRO C    C N N 409 
PRO O    O N N 410 
PRO CB   C N N 411 
PRO CG   C N N 412 
PRO CD   C N N 413 
PRO OXT  O N N 414 
PRO H    H N N 415 
PRO HA   H N N 416 
PRO HB2  H N N 417 
PRO HB3  H N N 418 
PRO HG2  H N N 419 
PRO HG3  H N N 420 
PRO HD2  H N N 421 
PRO HD3  H N N 422 
PRO HXT  H N N 423 
R16 C27  C N N 424 
R16 C28  C N N 425 
R16 C29  C N N 426 
R16 C30  C N N 427 
R16 C31  C N N 428 
R16 C32  C N N 429 
R16 C33  C N N 430 
R16 C34  C N N 431 
R16 C35  C N N 432 
R16 C36  C N N 433 
R16 C37  C N N 434 
R16 C38  C N N 435 
R16 C39  C N N 436 
R16 C40  C N N 437 
R16 C41  C N N 438 
R16 C42  C N N 439 
R16 H271 H N N 440 
R16 H272 H N N 441 
R16 H273 H N N 442 
R16 H281 H N N 443 
R16 H282 H N N 444 
R16 H291 H N N 445 
R16 H292 H N N 446 
R16 H301 H N N 447 
R16 H302 H N N 448 
R16 H311 H N N 449 
R16 H312 H N N 450 
R16 H321 H N N 451 
R16 H322 H N N 452 
R16 H331 H N N 453 
R16 H332 H N N 454 
R16 H341 H N N 455 
R16 H342 H N N 456 
R16 H351 H N N 457 
R16 H352 H N N 458 
R16 H361 H N N 459 
R16 H362 H N N 460 
R16 H371 H N N 461 
R16 H372 H N N 462 
R16 H381 H N N 463 
R16 H382 H N N 464 
R16 H391 H N N 465 
R16 H392 H N N 466 
R16 H401 H N N 467 
R16 H402 H N N 468 
R16 H411 H N N 469 
R16 H412 H N N 470 
R16 H421 H N N 471 
R16 H422 H N N 472 
R16 H423 H N N 473 
SER N    N N N 474 
SER CA   C N S 475 
SER C    C N N 476 
SER O    O N N 477 
SER CB   C N N 478 
SER OG   O N N 479 
SER OXT  O N N 480 
SER H    H N N 481 
SER H2   H N N 482 
SER HA   H N N 483 
SER HB2  H N N 484 
SER HB3  H N N 485 
SER HG   H N N 486 
SER HXT  H N N 487 
THR N    N N N 488 
THR CA   C N S 489 
THR C    C N N 490 
THR O    O N N 491 
THR CB   C N R 492 
THR OG1  O N N 493 
THR CG2  C N N 494 
THR OXT  O N N 495 
THR H    H N N 496 
THR H2   H N N 497 
THR HA   H N N 498 
THR HB   H N N 499 
THR HG1  H N N 500 
THR HG21 H N N 501 
THR HG22 H N N 502 
THR HG23 H N N 503 
THR HXT  H N N 504 
TRP N    N N N 505 
TRP CA   C N S 506 
TRP C    C N N 507 
TRP O    O N N 508 
TRP CB   C N N 509 
TRP CG   C Y N 510 
TRP CD1  C Y N 511 
TRP CD2  C Y N 512 
TRP NE1  N Y N 513 
TRP CE2  C Y N 514 
TRP CE3  C Y N 515 
TRP CZ2  C Y N 516 
TRP CZ3  C Y N 517 
TRP CH2  C Y N 518 
TRP OXT  O N N 519 
TRP H    H N N 520 
TRP H2   H N N 521 
TRP HA   H N N 522 
TRP HB2  H N N 523 
TRP HB3  H N N 524 
TRP HD1  H N N 525 
TRP HE1  H N N 526 
TRP HE3  H N N 527 
TRP HZ2  H N N 528 
TRP HZ3  H N N 529 
TRP HH2  H N N 530 
TRP HXT  H N N 531 
TYR N    N N N 532 
TYR CA   C N S 533 
TYR C    C N N 534 
TYR O    O N N 535 
TYR CB   C N N 536 
TYR CG   C Y N 537 
TYR CD1  C Y N 538 
TYR CD2  C Y N 539 
TYR CE1  C Y N 540 
TYR CE2  C Y N 541 
TYR CZ   C Y N 542 
TYR OH   O N N 543 
TYR OXT  O N N 544 
TYR H    H N N 545 
TYR H2   H N N 546 
TYR HA   H N N 547 
TYR HB2  H N N 548 
TYR HB3  H N N 549 
TYR HD1  H N N 550 
TYR HD2  H N N 551 
TYR HE1  H N N 552 
TYR HE2  H N N 553 
TYR HH   H N N 554 
TYR HXT  H N N 555 
VAL N    N N N 556 
VAL CA   C N S 557 
VAL C    C N N 558 
VAL O    O N N 559 
VAL CB   C N N 560 
VAL CG1  C N N 561 
VAL CG2  C N N 562 
VAL OXT  O N N 563 
VAL H    H N N 564 
VAL H2   H N N 565 
VAL HA   H N N 566 
VAL HB   H N N 567 
VAL HG11 H N N 568 
VAL HG12 H N N 569 
VAL HG13 H N N 570 
VAL HG21 H N N 571 
VAL HG22 H N N 572 
VAL HG23 H N N 573 
VAL HXT  H N N 574 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
D12 C1  C2   sing N N 83  
D12 C1  H11  sing N N 84  
D12 C1  H12  sing N N 85  
D12 C1  H13  sing N N 86  
D12 C2  C3   sing N N 87  
D12 C2  H21  sing N N 88  
D12 C2  H22  sing N N 89  
D12 C3  C4   sing N N 90  
D12 C3  H31  sing N N 91  
D12 C3  H32  sing N N 92  
D12 C4  C5   sing N N 93  
D12 C4  H41  sing N N 94  
D12 C4  H42  sing N N 95  
D12 C5  C6   sing N N 96  
D12 C5  H51  sing N N 97  
D12 C5  H52  sing N N 98  
D12 C6  C7   sing N N 99  
D12 C6  H61  sing N N 100 
D12 C6  H62  sing N N 101 
D12 C7  C8   sing N N 102 
D12 C7  H71  sing N N 103 
D12 C7  H72  sing N N 104 
D12 C8  C9   sing N N 105 
D12 C8  H81  sing N N 106 
D12 C8  H82  sing N N 107 
D12 C9  C10  sing N N 108 
D12 C9  H91  sing N N 109 
D12 C9  H92  sing N N 110 
D12 C10 C11  sing N N 111 
D12 C10 H101 sing N N 112 
D12 C10 H102 sing N N 113 
D12 C11 C12  sing N N 114 
D12 C11 H111 sing N N 115 
D12 C11 H112 sing N N 116 
D12 C12 H121 sing N N 117 
D12 C12 H122 sing N N 118 
D12 C12 H123 sing N N 119 
EIC C1  C2   sing N N 120 
EIC C1  O1   doub N N 121 
EIC C1  O2   sing N N 122 
EIC C2  C3   sing N N 123 
EIC C2  H21  sing N N 124 
EIC C2  H22  sing N N 125 
EIC C3  C4   sing N N 126 
EIC C3  H31  sing N N 127 
EIC C3  H32  sing N N 128 
EIC C4  C5   sing N N 129 
EIC C4  H41  sing N N 130 
EIC C4  H42  sing N N 131 
EIC C5  C6   sing N N 132 
EIC C5  H51  sing N N 133 
EIC C5  H52  sing N N 134 
EIC C6  C7   sing N N 135 
EIC C6  H61  sing N N 136 
EIC C6  H62  sing N N 137 
EIC C7  C8   sing N N 138 
EIC C7  H71  sing N N 139 
EIC C7  H72  sing N N 140 
EIC C8  C9   sing N N 141 
EIC C8  H81  sing N N 142 
EIC C8  H82  sing N N 143 
EIC C9  C10  doub N Z 144 
EIC C9  H91  sing N N 145 
EIC C10 C11  sing N N 146 
EIC C10 H1O1 sing N N 147 
EIC C11 C12  sing N N 148 
EIC C11 H111 sing N N 149 
EIC C11 H112 sing N N 150 
EIC C12 C13  doub N Z 151 
EIC C12 H121 sing N N 152 
EIC C13 C14  sing N N 153 
EIC C13 H131 sing N N 154 
EIC C14 C15  sing N N 155 
EIC C14 H141 sing N N 156 
EIC C14 H142 sing N N 157 
EIC C15 C16  sing N N 158 
EIC C15 H151 sing N N 159 
EIC C15 H152 sing N N 160 
EIC C16 C17  sing N N 161 
EIC C16 H161 sing N N 162 
EIC C16 H162 sing N N 163 
EIC C17 C18  sing N N 164 
EIC C17 H171 sing N N 165 
EIC C17 H172 sing N N 166 
EIC C18 H181 sing N N 167 
EIC C18 H182 sing N N 168 
EIC C18 H183 sing N N 169 
EIC O2  HO2  sing N N 170 
GLN N   CA   sing N N 171 
GLN N   H    sing N N 172 
GLN N   H2   sing N N 173 
GLN CA  C    sing N N 174 
GLN CA  CB   sing N N 175 
GLN CA  HA   sing N N 176 
GLN C   O    doub N N 177 
GLN C   OXT  sing N N 178 
GLN CB  CG   sing N N 179 
GLN CB  HB2  sing N N 180 
GLN CB  HB3  sing N N 181 
GLN CG  CD   sing N N 182 
GLN CG  HG2  sing N N 183 
GLN CG  HG3  sing N N 184 
GLN CD  OE1  doub N N 185 
GLN CD  NE2  sing N N 186 
GLN NE2 HE21 sing N N 187 
GLN NE2 HE22 sing N N 188 
GLN OXT HXT  sing N N 189 
GLU N   CA   sing N N 190 
GLU N   H    sing N N 191 
GLU N   H2   sing N N 192 
GLU CA  C    sing N N 193 
GLU CA  CB   sing N N 194 
GLU CA  HA   sing N N 195 
GLU C   O    doub N N 196 
GLU C   OXT  sing N N 197 
GLU CB  CG   sing N N 198 
GLU CB  HB2  sing N N 199 
GLU CB  HB3  sing N N 200 
GLU CG  CD   sing N N 201 
GLU CG  HG2  sing N N 202 
GLU CG  HG3  sing N N 203 
GLU CD  OE1  doub N N 204 
GLU CD  OE2  sing N N 205 
GLU OE2 HE2  sing N N 206 
GLU OXT HXT  sing N N 207 
GLY N   CA   sing N N 208 
GLY N   H    sing N N 209 
GLY N   H2   sing N N 210 
GLY CA  C    sing N N 211 
GLY CA  HA2  sing N N 212 
GLY CA  HA3  sing N N 213 
GLY C   O    doub N N 214 
GLY C   OXT  sing N N 215 
GLY OXT HXT  sing N N 216 
HEX C1  C2   sing N N 217 
HEX C1  H11  sing N N 218 
HEX C1  H12  sing N N 219 
HEX C1  H13  sing N N 220 
HEX C2  C3   sing N N 221 
HEX C2  H21  sing N N 222 
HEX C2  H22  sing N N 223 
HEX C3  C4   sing N N 224 
HEX C3  H31  sing N N 225 
HEX C3  H32  sing N N 226 
HEX C4  C5   sing N N 227 
HEX C4  H41  sing N N 228 
HEX C4  H42  sing N N 229 
HEX C5  C6   sing N N 230 
HEX C5  H51  sing N N 231 
HEX C5  H52  sing N N 232 
HEX C6  H61  sing N N 233 
HEX C6  H62  sing N N 234 
HEX C6  H63  sing N N 235 
HIS N   CA   sing N N 236 
HIS N   H    sing N N 237 
HIS N   H2   sing N N 238 
HIS CA  C    sing N N 239 
HIS CA  CB   sing N N 240 
HIS CA  HA   sing N N 241 
HIS C   O    doub N N 242 
HIS C   OXT  sing N N 243 
HIS CB  CG   sing N N 244 
HIS CB  HB2  sing N N 245 
HIS CB  HB3  sing N N 246 
HIS CG  ND1  sing Y N 247 
HIS CG  CD2  doub Y N 248 
HIS ND1 CE1  doub Y N 249 
HIS ND1 HD1  sing N N 250 
HIS CD2 NE2  sing Y N 251 
HIS CD2 HD2  sing N N 252 
HIS CE1 NE2  sing Y N 253 
HIS CE1 HE1  sing N N 254 
HIS NE2 HE2  sing N N 255 
HIS OXT HXT  sing N N 256 
ILE N   CA   sing N N 257 
ILE N   H    sing N N 258 
ILE N   H2   sing N N 259 
ILE CA  C    sing N N 260 
ILE CA  CB   sing N N 261 
ILE CA  HA   sing N N 262 
ILE C   O    doub N N 263 
ILE C   OXT  sing N N 264 
ILE CB  CG1  sing N N 265 
ILE CB  CG2  sing N N 266 
ILE CB  HB   sing N N 267 
ILE CG1 CD1  sing N N 268 
ILE CG1 HG12 sing N N 269 
ILE CG1 HG13 sing N N 270 
ILE CG2 HG21 sing N N 271 
ILE CG2 HG22 sing N N 272 
ILE CG2 HG23 sing N N 273 
ILE CD1 HD11 sing N N 274 
ILE CD1 HD12 sing N N 275 
ILE CD1 HD13 sing N N 276 
ILE OXT HXT  sing N N 277 
LEU N   CA   sing N N 278 
LEU N   H    sing N N 279 
LEU N   H2   sing N N 280 
LEU CA  C    sing N N 281 
LEU CA  CB   sing N N 282 
LEU CA  HA   sing N N 283 
LEU C   O    doub N N 284 
LEU C   OXT  sing N N 285 
LEU CB  CG   sing N N 286 
LEU CB  HB2  sing N N 287 
LEU CB  HB3  sing N N 288 
LEU CG  CD1  sing N N 289 
LEU CG  CD2  sing N N 290 
LEU CG  HG   sing N N 291 
LEU CD1 HD11 sing N N 292 
LEU CD1 HD12 sing N N 293 
LEU CD1 HD13 sing N N 294 
LEU CD2 HD21 sing N N 295 
LEU CD2 HD22 sing N N 296 
LEU CD2 HD23 sing N N 297 
LEU OXT HXT  sing N N 298 
LYS N   CA   sing N N 299 
LYS N   H    sing N N 300 
LYS N   H2   sing N N 301 
LYS CA  C    sing N N 302 
LYS CA  CB   sing N N 303 
LYS CA  HA   sing N N 304 
LYS C   O    doub N N 305 
LYS C   OXT  sing N N 306 
LYS CB  CG   sing N N 307 
LYS CB  HB2  sing N N 308 
LYS CB  HB3  sing N N 309 
LYS CG  CD   sing N N 310 
LYS CG  HG2  sing N N 311 
LYS CG  HG3  sing N N 312 
LYS CD  CE   sing N N 313 
LYS CD  HD2  sing N N 314 
LYS CD  HD3  sing N N 315 
LYS CE  NZ   sing N N 316 
LYS CE  HE2  sing N N 317 
LYS CE  HE3  sing N N 318 
LYS NZ  HZ1  sing N N 319 
LYS NZ  HZ2  sing N N 320 
LYS NZ  HZ3  sing N N 321 
LYS OXT HXT  sing N N 322 
MET N   CA   sing N N 323 
MET N   H    sing N N 324 
MET N   H2   sing N N 325 
MET CA  C    sing N N 326 
MET CA  CB   sing N N 327 
MET CA  HA   sing N N 328 
MET C   O    doub N N 329 
MET C   OXT  sing N N 330 
MET CB  CG   sing N N 331 
MET CB  HB2  sing N N 332 
MET CB  HB3  sing N N 333 
MET CG  SD   sing N N 334 
MET CG  HG2  sing N N 335 
MET CG  HG3  sing N N 336 
MET SD  CE   sing N N 337 
MET CE  HE1  sing N N 338 
MET CE  HE2  sing N N 339 
MET CE  HE3  sing N N 340 
MET OXT HXT  sing N N 341 
OCT C1  C2   sing N N 342 
OCT C1  H11  sing N N 343 
OCT C1  H12  sing N N 344 
OCT C1  H13  sing N N 345 
OCT C2  C3   sing N N 346 
OCT C2  H21  sing N N 347 
OCT C2  H22  sing N N 348 
OCT C3  C4   sing N N 349 
OCT C3  H31  sing N N 350 
OCT C3  H32  sing N N 351 
OCT C4  C5   sing N N 352 
OCT C4  H41  sing N N 353 
OCT C4  H42  sing N N 354 
OCT C5  C6   sing N N 355 
OCT C5  H51  sing N N 356 
OCT C5  H52  sing N N 357 
OCT C6  C7   sing N N 358 
OCT C6  H61  sing N N 359 
OCT C6  H62  sing N N 360 
OCT C7  C8   sing N N 361 
OCT C7  H71  sing N N 362 
OCT C7  H72  sing N N 363 
OCT C8  H81  sing N N 364 
OCT C8  H82  sing N N 365 
OCT C8  H83  sing N N 366 
PHE N   CA   sing N N 367 
PHE N   H    sing N N 368 
PHE N   H2   sing N N 369 
PHE CA  C    sing N N 370 
PHE CA  CB   sing N N 371 
PHE CA  HA   sing N N 372 
PHE C   O    doub N N 373 
PHE C   OXT  sing N N 374 
PHE CB  CG   sing N N 375 
PHE CB  HB2  sing N N 376 
PHE CB  HB3  sing N N 377 
PHE CG  CD1  doub Y N 378 
PHE CG  CD2  sing Y N 379 
PHE CD1 CE1  sing Y N 380 
PHE CD1 HD1  sing N N 381 
PHE CD2 CE2  doub Y N 382 
PHE CD2 HD2  sing N N 383 
PHE CE1 CZ   doub Y N 384 
PHE CE1 HE1  sing N N 385 
PHE CE2 CZ   sing Y N 386 
PHE CE2 HE2  sing N N 387 
PHE CZ  HZ   sing N N 388 
PHE OXT HXT  sing N N 389 
PRO N   CA   sing N N 390 
PRO N   CD   sing N N 391 
PRO N   H    sing N N 392 
PRO CA  C    sing N N 393 
PRO CA  CB   sing N N 394 
PRO CA  HA   sing N N 395 
PRO C   O    doub N N 396 
PRO C   OXT  sing N N 397 
PRO CB  CG   sing N N 398 
PRO CB  HB2  sing N N 399 
PRO CB  HB3  sing N N 400 
PRO CG  CD   sing N N 401 
PRO CG  HG2  sing N N 402 
PRO CG  HG3  sing N N 403 
PRO CD  HD2  sing N N 404 
PRO CD  HD3  sing N N 405 
PRO OXT HXT  sing N N 406 
R16 C27 C28  sing N N 407 
R16 C27 H271 sing N N 408 
R16 C27 H272 sing N N 409 
R16 C27 H273 sing N N 410 
R16 C28 C29  sing N N 411 
R16 C28 H281 sing N N 412 
R16 C28 H282 sing N N 413 
R16 C29 C30  sing N N 414 
R16 C29 H291 sing N N 415 
R16 C29 H292 sing N N 416 
R16 C30 C31  sing N N 417 
R16 C30 H301 sing N N 418 
R16 C30 H302 sing N N 419 
R16 C31 C32  sing N N 420 
R16 C31 H311 sing N N 421 
R16 C31 H312 sing N N 422 
R16 C32 C33  sing N N 423 
R16 C32 H321 sing N N 424 
R16 C32 H322 sing N N 425 
R16 C33 C34  sing N N 426 
R16 C33 H331 sing N N 427 
R16 C33 H332 sing N N 428 
R16 C34 C35  sing N N 429 
R16 C34 H341 sing N N 430 
R16 C34 H342 sing N N 431 
R16 C35 C36  sing N N 432 
R16 C35 H351 sing N N 433 
R16 C35 H352 sing N N 434 
R16 C36 C37  sing N N 435 
R16 C36 H361 sing N N 436 
R16 C36 H362 sing N N 437 
R16 C37 C38  sing N N 438 
R16 C37 H371 sing N N 439 
R16 C37 H372 sing N N 440 
R16 C38 C39  sing N N 441 
R16 C38 H381 sing N N 442 
R16 C38 H382 sing N N 443 
R16 C39 C40  sing N N 444 
R16 C39 H391 sing N N 445 
R16 C39 H392 sing N N 446 
R16 C40 C41  sing N N 447 
R16 C40 H401 sing N N 448 
R16 C40 H402 sing N N 449 
R16 C41 C42  sing N N 450 
R16 C41 H411 sing N N 451 
R16 C41 H412 sing N N 452 
R16 C42 H421 sing N N 453 
R16 C42 H422 sing N N 454 
R16 C42 H423 sing N N 455 
SER N   CA   sing N N 456 
SER N   H    sing N N 457 
SER N   H2   sing N N 458 
SER CA  C    sing N N 459 
SER CA  CB   sing N N 460 
SER CA  HA   sing N N 461 
SER C   O    doub N N 462 
SER C   OXT  sing N N 463 
SER CB  OG   sing N N 464 
SER CB  HB2  sing N N 465 
SER CB  HB3  sing N N 466 
SER OG  HG   sing N N 467 
SER OXT HXT  sing N N 468 
THR N   CA   sing N N 469 
THR N   H    sing N N 470 
THR N   H2   sing N N 471 
THR CA  C    sing N N 472 
THR CA  CB   sing N N 473 
THR CA  HA   sing N N 474 
THR C   O    doub N N 475 
THR C   OXT  sing N N 476 
THR CB  OG1  sing N N 477 
THR CB  CG2  sing N N 478 
THR CB  HB   sing N N 479 
THR OG1 HG1  sing N N 480 
THR CG2 HG21 sing N N 481 
THR CG2 HG22 sing N N 482 
THR CG2 HG23 sing N N 483 
THR OXT HXT  sing N N 484 
TRP N   CA   sing N N 485 
TRP N   H    sing N N 486 
TRP N   H2   sing N N 487 
TRP CA  C    sing N N 488 
TRP CA  CB   sing N N 489 
TRP CA  HA   sing N N 490 
TRP C   O    doub N N 491 
TRP C   OXT  sing N N 492 
TRP CB  CG   sing N N 493 
TRP CB  HB2  sing N N 494 
TRP CB  HB3  sing N N 495 
TRP CG  CD1  doub Y N 496 
TRP CG  CD2  sing Y N 497 
TRP CD1 NE1  sing Y N 498 
TRP CD1 HD1  sing N N 499 
TRP CD2 CE2  doub Y N 500 
TRP CD2 CE3  sing Y N 501 
TRP NE1 CE2  sing Y N 502 
TRP NE1 HE1  sing N N 503 
TRP CE2 CZ2  sing Y N 504 
TRP CE3 CZ3  doub Y N 505 
TRP CE3 HE3  sing N N 506 
TRP CZ2 CH2  doub Y N 507 
TRP CZ2 HZ2  sing N N 508 
TRP CZ3 CH2  sing Y N 509 
TRP CZ3 HZ3  sing N N 510 
TRP CH2 HH2  sing N N 511 
TRP OXT HXT  sing N N 512 
TYR N   CA   sing N N 513 
TYR N   H    sing N N 514 
TYR N   H2   sing N N 515 
TYR CA  C    sing N N 516 
TYR CA  CB   sing N N 517 
TYR CA  HA   sing N N 518 
TYR C   O    doub N N 519 
TYR C   OXT  sing N N 520 
TYR CB  CG   sing N N 521 
TYR CB  HB2  sing N N 522 
TYR CB  HB3  sing N N 523 
TYR CG  CD1  doub Y N 524 
TYR CG  CD2  sing Y N 525 
TYR CD1 CE1  sing Y N 526 
TYR CD1 HD1  sing N N 527 
TYR CD2 CE2  doub Y N 528 
TYR CD2 HD2  sing N N 529 
TYR CE1 CZ   doub Y N 530 
TYR CE1 HE1  sing N N 531 
TYR CE2 CZ   sing Y N 532 
TYR CE2 HE2  sing N N 533 
TYR CZ  OH   sing N N 534 
TYR OH  HH   sing N N 535 
TYR OXT HXT  sing N N 536 
VAL N   CA   sing N N 537 
VAL N   H    sing N N 538 
VAL N   H2   sing N N 539 
VAL CA  C    sing N N 540 
VAL CA  CB   sing N N 541 
VAL CA  HA   sing N N 542 
VAL C   O    doub N N 543 
VAL C   OXT  sing N N 544 
VAL CB  CG1  sing N N 545 
VAL CB  CG2  sing N N 546 
VAL CB  HB   sing N N 547 
VAL CG1 HG11 sing N N 548 
VAL CG1 HG12 sing N N 549 
VAL CG1 HG13 sing N N 550 
VAL CG2 HG21 sing N N 551 
VAL CG2 HG22 sing N N 552 
VAL CG2 HG23 sing N N 553 
VAL OXT HXT  sing N N 554 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-05-24 
_em_admin.deposition_site    RCSB 
_em_admin.entry_id           9C07 
_em_admin.last_update        2025-05-14 
_em_admin.map_release_date   2025-02-26 
_em_admin.title              'Structure of K2P13.1 (THIK1) S136P in detergent' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   2 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   2 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         46 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ?         ?   
'IMAGE ACQUISITION'             ? 2  ? ? 1 ?         ?   
MASKING                         ? 3  ? ? ? ?         ?   
'CTF CORRECTION'                ? 4  1 ? ? ?         ?   
'LAYERLINE INDEXING'            ? 5  ? ? ? ?         ?   
'DIFFRACTION INDEXING'          ? 6  ? ? ? ?         ?   
'MODEL FITTING'                 ? 7  ? ? ? ?         ?   
'MODEL REFINEMENT'              ? 8  ? ? ? PHENIX    ?   
OTHER                           ? 9  ? ? ? ?         ?   
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ?         ?   
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ?         ?   
CLASSIFICATION                  ? 12 1 ? ? ?         ?   
RECONSTRUCTION                  ? 13 1 ? ? cryoSPARC 3.2 
'VOLUME SELECTION'              ? 14 1 1 1 ?         ?   
'SERIES ALIGNMENT'              ? 15 1 1 1 ?         ?   
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ?         ?   
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ?         ?   
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ?         ?   
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ?         ?   
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'National Institutes of Health/National Institute of Mental Health (NIH/NIMH)' 
_pdbx_audit_support.country                'United States' 
_pdbx_audit_support.grant_number           'R01 MH093603' 
_pdbx_audit_support.ordinal                1 
# 
_atom_sites.entry_id                    9C07 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
H 
K 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N    . ASN A  1 14  ? 111.435 101.541 141.977 1.00 48.27  ? 14  ASN U N    1 
ATOM   2    C CA   . ASN A  1 14  ? 110.496 101.048 140.978 1.00 49.40  ? 14  ASN U CA   1 
ATOM   3    C C    . ASN A  1 14  ? 109.713 102.202 140.366 1.00 52.70  ? 14  ASN U C    1 
ATOM   4    O O    . ASN A  1 14  ? 109.090 102.053 139.317 1.00 55.80  ? 14  ASN U O    1 
ATOM   5    C CB   . ASN A  1 14  ? 109.539 100.025 141.596 1.00 48.97  ? 14  ASN U CB   1 
ATOM   6    C CG   . ASN A  1 14  ? 108.679 99.327  140.559 1.00 50.85  ? 14  ASN U CG   1 
ATOM   7    O OD1  . ASN A  1 14  ? 108.919 99.436  139.359 1.00 54.21  ? 14  ASN U OD1  1 
ATOM   8    N ND2  . ASN A  1 14  ? 107.673 98.596  141.022 1.00 48.60  ? 14  ASN U ND2  1 
ATOM   9    N N    . GLU A  1 15  ? 109.745 103.359 141.029 1.00 52.15  ? 15  GLU U N    1 
ATOM   10   C CA   . GLU A  1 15  ? 109.058 104.529 140.492 1.00 50.18  ? 15  GLU U CA   1 
ATOM   11   C C    . GLU A  1 15  ? 109.813 105.124 139.311 1.00 55.43  ? 15  GLU U C    1 
ATOM   12   O O    . GLU A  1 15  ? 109.203 105.509 138.305 1.00 58.18  ? 15  GLU U O    1 
ATOM   13   C CB   . GLU A  1 15  ? 108.871 105.576 141.588 1.00 50.79  ? 15  GLU U CB   1 
ATOM   14   C CG   . GLU A  1 15  ? 108.217 106.855 141.104 1.00 57.29  ? 15  GLU U CG   1 
ATOM   15   C CD   . GLU A  1 15  ? 108.065 107.882 142.207 1.00 64.07  ? 15  GLU U CD   1 
ATOM   16   O OE1  . GLU A  1 15  ? 108.455 107.583 143.355 1.00 61.66  ? 15  GLU U OE1  1 
ATOM   17   O OE2  . GLU A  1 15  ? 107.557 108.987 141.927 1.00 61.07  ? 15  GLU U OE2  1 
ATOM   18   N N    . ASP A  1 16  ? 111.141 105.214 139.412 1.00 48.98  ? 16  ASP U N    1 
ATOM   19   C CA   . ASP A  1 16  ? 111.925 105.769 138.315 1.00 45.37  ? 16  ASP U CA   1 
ATOM   20   C C    . ASP A  1 16  ? 111.791 104.918 137.059 1.00 49.30  ? 16  ASP U C    1 
ATOM   21   O O    . ASP A  1 16  ? 111.644 105.448 135.951 1.00 52.79  ? 16  ASP U O    1 
ATOM   22   C CB   . ASP A  1 16  ? 113.390 105.892 138.727 1.00 46.82  ? 16  ASP U CB   1 
ATOM   23   C CG   . ASP A  1 16  ? 113.582 106.800 139.922 1.00 54.45  ? 16  ASP U CG   1 
ATOM   24   O OD1  . ASP A  1 16  ? 112.816 107.775 140.057 1.00 60.31  ? 16  ASP U OD1  1 
ATOM   25   O OD2  . ASP A  1 16  ? 114.498 106.542 140.728 1.00 54.88  ? 16  ASP U OD2  1 
ATOM   26   N N    . ASN A  1 17  ? 111.839 103.594 137.212 1.00 42.19  ? 17  ASN U N    1 
ATOM   27   C CA   . ASN A  1 17  ? 111.657 102.715 136.064 1.00 43.07  ? 17  ASN U CA   1 
ATOM   28   C C    . ASN A  1 17  ? 110.270 102.886 135.458 1.00 44.88  ? 17  ASN U C    1 
ATOM   29   O O    . ASN A  1 17  ? 110.114 102.886 134.232 1.00 47.13  ? 17  ASN U O    1 
ATOM   30   C CB   . ASN A  1 17  ? 111.886 101.263 136.475 1.00 44.14  ? 17  ASN U CB   1 
ATOM   31   C CG   . ASN A  1 17  ? 113.232 101.051 137.125 1.00 48.51  ? 17  ASN U CG   1 
ATOM   32   O OD1  . ASN A  1 17  ? 114.175 101.800 136.879 1.00 49.95  ? 17  ASN U OD1  1 
ATOM   33   N ND2  . ASN A  1 17  ? 113.332 100.026 137.960 1.00 49.95  ? 17  ASN U ND2  1 
ATOM   34   N N    . ALA A  1 18  ? 109.247 103.022 136.304 1.00 38.76  ? 18  ALA U N    1 
ATOM   35   C CA   . ALA A  1 18  ? 107.898 103.224 135.794 1.00 38.06  ? 18  ALA U CA   1 
ATOM   36   C C    . ALA A  1 18  ? 107.803 104.512 134.989 1.00 39.81  ? 18  ALA U C    1 
ATOM   37   O O    . ALA A  1 18  ? 107.208 104.532 133.906 1.00 42.67  ? 18  ALA U O    1 
ATOM   38   C CB   . ALA A  1 18  ? 106.896 103.236 136.946 1.00 33.74  ? 18  ALA U CB   1 
ATOM   39   N N    . ARG A  1 19  ? 108.383 105.599 135.500 1.00 34.63  ? 19  ARG U N    1 
ATOM   40   C CA   . ARG A  1 19  ? 108.353 106.856 134.761 1.00 30.87  ? 19  ARG U CA   1 
ATOM   41   C C    . ARG A  1 19  ? 109.102 106.734 133.439 1.00 34.61  ? 19  ARG U C    1 
ATOM   42   O O    . ARG A  1 19  ? 108.640 107.234 132.406 1.00 42.85  ? 19  ARG U O    1 
ATOM   43   C CB   . ARG A  1 19  ? 108.937 107.982 135.613 1.00 31.42  ? 19  ARG U CB   1 
ATOM   44   C CG   . ARG A  1 19  ? 109.144 109.274 134.854 1.00 37.38  ? 19  ARG U CG   1 
ATOM   45   C CD   . ARG A  1 19  ? 109.348 110.456 135.783 1.00 36.51  ? 19  ARG U CD   1 
ATOM   46   N NE   . ARG A  1 19  ? 110.425 110.241 136.740 1.00 36.86  ? 19  ARG U NE   1 
ATOM   47   C CZ   . ARG A  1 19  ? 110.245 110.071 138.041 1.00 37.54  ? 19  ARG U CZ   1 
ATOM   48   N NH1  . ARG A  1 19  ? 109.038 110.091 138.580 1.00 34.74  ? 19  ARG U NH1  1 
ATOM   49   N NH2  . ARG A  1 19  ? 111.303 109.884 138.823 1.00 40.47  ? 19  ARG U NH2  1 
ATOM   50   N N    . PHE A  1 20  ? 110.253 106.062 133.452 1.00 29.70  ? 20  PHE U N    1 
ATOM   51   C CA   . PHE A  1 20  ? 111.024 105.871 132.226 1.00 26.81  ? 20  PHE U CA   1 
ATOM   52   C C    . PHE A  1 20  ? 110.207 105.118 131.181 1.00 32.87  ? 20  PHE U C    1 
ATOM   53   O O    . PHE A  1 20  ? 110.113 105.538 130.018 1.00 36.54  ? 20  PHE U O    1 
ATOM   54   C CB   . PHE A  1 20  ? 112.312 105.120 132.566 1.00 21.11  ? 20  PHE U CB   1 
ATOM   55   C CG   . PHE A  1 20  ? 113.384 105.230 131.527 1.00 27.72  ? 20  PHE U CG   1 
ATOM   56   C CD1  . PHE A  1 20  ? 113.708 106.450 130.972 1.00 32.30  ? 20  PHE U CD1  1 
ATOM   57   C CD2  . PHE A  1 20  ? 114.094 104.112 131.132 1.00 28.11  ? 20  PHE U CD2  1 
ATOM   58   C CE1  . PHE A  1 20  ? 114.703 106.548 130.024 1.00 32.73  ? 20  PHE U CE1  1 
ATOM   59   C CE2  . PHE A  1 20  ? 115.089 104.205 130.187 1.00 25.27  ? 20  PHE U CE2  1 
ATOM   60   C CZ   . PHE A  1 20  ? 115.394 105.424 129.633 1.00 24.88  ? 20  PHE U CZ   1 
ATOM   61   N N    . LEU A  1 21  ? 109.590 104.009 131.589 1.00 33.51  ? 21  LEU U N    1 
ATOM   62   C CA   . LEU A  1 21  ? 108.799 103.207 130.662 1.00 28.60  ? 21  LEU U CA   1 
ATOM   63   C C    . LEU A  1 21  ? 107.599 103.986 130.136 1.00 31.54  ? 21  LEU U C    1 
ATOM   64   O O    . LEU A  1 21  ? 107.283 103.927 128.939 1.00 39.00  ? 21  LEU U O    1 
ATOM   65   C CB   . LEU A  1 21  ? 108.348 101.924 131.357 1.00 29.28  ? 21  LEU U CB   1 
ATOM   66   C CG   . LEU A  1 21  ? 107.578 100.899 130.533 1.00 30.43  ? 21  LEU U CG   1 
ATOM   67   C CD1  . LEU A  1 21  ? 108.439 100.384 129.398 1.00 32.98  ? 21  LEU U CD1  1 
ATOM   68   C CD2  . LEU A  1 21  ? 107.122 99.761  131.424 1.00 27.51  ? 21  LEU U CD2  1 
ATOM   69   N N    . LEU A  1 22  ? 106.913 104.716 131.017 1.00 29.19  ? 22  LEU U N    1 
ATOM   70   C CA   . LEU A  1 22  ? 105.757 105.494 130.589 1.00 30.59  ? 22  LEU U CA   1 
ATOM   71   C C    . LEU A  1 22  ? 106.155 106.549 129.568 1.00 34.37  ? 22  LEU U C    1 
ATOM   72   O O    . LEU A  1 22  ? 105.468 106.738 128.556 1.00 39.94  ? 22  LEU U O    1 
ATOM   73   C CB   . LEU A  1 22  ? 105.090 106.139 131.802 1.00 29.61  ? 22  LEU U CB   1 
ATOM   74   C CG   . LEU A  1 22  ? 103.810 106.929 131.553 1.00 33.54  ? 22  LEU U CG   1 
ATOM   75   C CD1  . LEU A  1 22  ? 102.713 106.013 131.053 1.00 30.66  ? 22  LEU U CD1  1 
ATOM   76   C CD2  . LEU A  1 22  ? 103.378 107.642 132.816 1.00 32.29  ? 22  LEU U CD2  1 
ATOM   77   N N    . LEU A  1 23  ? 107.263 107.249 129.816 1.00 23.98  ? 23  LEU U N    1 
ATOM   78   C CA   . LEU A  1 23  ? 107.712 108.257 128.863 1.00 19.61  ? 23  LEU U CA   1 
ATOM   79   C C    . LEU A  1 23  ? 108.059 107.625 127.523 1.00 29.54  ? 23  LEU U C    1 
ATOM   80   O O    . LEU A  1 23  ? 107.728 108.176 126.465 1.00 34.17  ? 23  LEU U O    1 
ATOM   81   C CB   . LEU A  1 23  ? 108.908 109.018 129.428 1.00 20.47  ? 23  LEU U CB   1 
ATOM   82   C CG   . LEU A  1 23  ? 109.380 110.203 128.590 1.00 25.91  ? 23  LEU U CG   1 
ATOM   83   C CD1  . LEU A  1 23  ? 108.239 111.170 128.359 1.00 26.48  ? 23  LEU U CD1  1 
ATOM   84   C CD2  . LEU A  1 23  ? 110.541 110.900 129.267 1.00 23.99  ? 23  LEU U CD2  1 
ATOM   85   N N    . ALA A  1 24  ? 108.722 106.467 127.543 1.00 30.70  ? 24  ALA U N    1 
ATOM   86   C CA   . ALA A  1 24  ? 109.058 105.801 126.287 1.00 22.62  ? 24  ALA U CA   1 
ATOM   87   C C    . ALA A  1 24  ? 107.801 105.455 125.495 1.00 32.25  ? 24  ALA U C    1 
ATOM   88   O O    . ALA A  1 24  ? 107.719 105.715 124.286 1.00 37.20  ? 24  ALA U O    1 
ATOM   89   C CB   . ALA A  1 24  ? 109.882 104.547 126.566 1.00 21.25  ? 24  ALA U CB   1 
ATOM   90   N N    . ALA A  1 25  ? 106.804 104.871 126.164 1.00 26.31  ? 25  ALA U N    1 
ATOM   91   C CA   . ALA A  1 25  ? 105.579 104.494 125.463 1.00 23.99  ? 25  ALA U CA   1 
ATOM   92   C C    . ALA A  1 25  ? 104.869 105.716 124.895 1.00 28.09  ? 25  ALA U C    1 
ATOM   93   O O    . ALA A  1 25  ? 104.392 105.697 123.748 1.00 32.90  ? 25  ALA U O    1 
ATOM   94   C CB   . ALA A  1 25  ? 104.652 103.725 126.402 1.00 21.78  ? 25  ALA U CB   1 
ATOM   95   N N    . LEU A  1 26  ? 104.787 106.791 125.680 1.00 29.17  ? 26  LEU U N    1 
ATOM   96   C CA   . LEU A  1 26  ? 104.123 107.994 125.196 1.00 23.92  ? 26  LEU U CA   1 
ATOM   97   C C    . LEU A  1 26  ? 104.841 108.565 123.981 1.00 24.26  ? 26  LEU U C    1 
ATOM   98   O O    . LEU A  1 26  ? 104.197 108.987 123.015 1.00 30.98  ? 26  LEU U O    1 
ATOM   99   C CB   . LEU A  1 26  ? 104.033 109.034 126.310 1.00 27.11  ? 26  LEU U CB   1 
ATOM   100  C CG   . LEU A  1 26  ? 103.153 108.657 127.498 1.00 22.14  ? 26  LEU U CG   1 
ATOM   101  C CD1  . LEU A  1 26  ? 103.076 109.805 128.482 1.00 24.28  ? 26  LEU U CD1  1 
ATOM   102  C CD2  . LEU A  1 26  ? 101.768 108.260 127.030 1.00 22.97  ? 26  LEU U CD2  1 
ATOM   103  N N    . ILE A  1 27  ? 106.175 108.581 124.004 1.00 20.22  ? 27  ILE U N    1 
ATOM   104  C CA   . ILE A  1 27  ? 106.913 109.115 122.865 1.00 22.32  ? 27  ILE U CA   1 
ATOM   105  C C    . ILE A  1 27  ? 106.690 108.257 121.628 1.00 23.54  ? 27  ILE U C    1 
ATOM   106  O O    . ILE A  1 27  ? 106.585 108.774 120.510 1.00 26.84  ? 27  ILE U O    1 
ATOM   107  C CB   . ILE A  1 27  ? 108.408 109.245 123.198 1.00 25.96  ? 27  ILE U CB   1 
ATOM   108  C CG1  . ILE A  1 27  ? 108.616 110.235 124.340 1.00 20.46  ? 27  ILE U CG1  1 
ATOM   109  C CG2  . ILE A  1 27  ? 109.178 109.697 121.978 1.00 25.61  ? 27  ILE U CG2  1 
ATOM   110  C CD1  . ILE A  1 27  ? 110.064 110.521 124.628 1.00 15.42  ? 27  ILE U CD1  1 
ATOM   111  N N    . VAL A  1 28  ? 106.625 106.935 121.797 1.00 26.91  ? 28  VAL U N    1 
ATOM   112  C CA   . VAL A  1 28  ? 106.388 106.064 120.644 1.00 25.99  ? 28  VAL U CA   1 
ATOM   113  C C    . VAL A  1 28  ? 105.025 106.359 120.024 1.00 25.12  ? 28  VAL U C    1 
ATOM   114  O O    . VAL A  1 28  ? 104.889 106.486 118.796 1.00 29.86  ? 28  VAL U O    1 
ATOM   115  C CB   . VAL A  1 28  ? 106.516 104.587 121.048 1.00 25.85  ? 28  VAL U CB   1 
ATOM   116  C CG1  . VAL A  1 28  ? 106.036 103.695 119.923 1.00 23.70  ? 28  VAL U CG1  1 
ATOM   117  C CG2  . VAL A  1 28  ? 107.954 104.265 121.399 1.00 26.03  ? 28  VAL U CG2  1 
ATOM   118  N N    . LEU A  1 29  ? 103.992 106.469 120.862 1.00 21.20  ? 29  LEU U N    1 
ATOM   119  C CA   . LEU A  1 29  ? 102.667 106.787 120.333 1.00 24.21  ? 29  LEU U CA   1 
ATOM   120  C C    . LEU A  1 29  ? 102.665 108.144 119.640 1.00 29.63  ? 29  LEU U C    1 
ATOM   121  O O    . LEU A  1 29  ? 102.038 108.317 118.585 1.00 33.14  ? 29  LEU U O    1 
ATOM   122  C CB   . LEU A  1 29  ? 101.629 106.755 121.452 1.00 24.15  ? 29  LEU U CB   1 
ATOM   123  C CG   . LEU A  1 29  ? 101.332 105.385 122.054 1.00 26.48  ? 29  LEU U CG   1 
ATOM   124  C CD1  . LEU A  1 29  ? 100.216 105.486 123.074 1.00 22.50  ? 29  LEU U CD1  1 
ATOM   125  C CD2  . LEU A  1 29  ? 100.973 104.395 120.964 1.00 25.49  ? 29  LEU U CD2  1 
ATOM   126  N N    . TYR A  1 30  ? 103.357 109.120 120.228 1.00 23.79  ? 30  TYR U N    1 
ATOM   127  C CA   . TYR A  1 30  ? 103.444 110.447 119.633 1.00 18.29  ? 30  TYR U CA   1 
ATOM   128  C C    . TYR A  1 30  ? 104.067 110.379 118.246 1.00 22.71  ? 30  TYR U C    1 
ATOM   129  O O    . TYR A  1 30  ? 103.572 110.997 117.295 1.00 25.94  ? 30  TYR U O    1 
ATOM   130  C CB   . TYR A  1 30  ? 104.255 111.354 120.557 1.00 16.48  ? 30  TYR U CB   1 
ATOM   131  C CG   . TYR A  1 30  ? 104.168 112.830 120.263 1.00 24.49  ? 30  TYR U CG   1 
ATOM   132  C CD1  . TYR A  1 30  ? 102.999 113.535 120.502 1.00 18.12  ? 30  TYR U CD1  1 
ATOM   133  C CD2  . TYR A  1 30  ? 105.265 113.523 119.781 1.00 18.31  ? 30  TYR U CD2  1 
ATOM   134  C CE1  . TYR A  1 30  ? 102.920 114.884 120.245 1.00 14.14  ? 30  TYR U CE1  1 
ATOM   135  C CE2  . TYR A  1 30  ? 105.194 114.872 119.523 1.00 19.90  ? 30  TYR U CE2  1 
ATOM   136  C CZ   . TYR A  1 30  ? 104.020 115.547 119.757 1.00 17.66  ? 30  TYR U CZ   1 
ATOM   137  O OH   . TYR A  1 30  ? 103.947 116.893 119.500 1.00 26.50  ? 30  TYR U OH   1 
ATOM   138  N N    . LEU A  1 31  ? 105.154 109.618 118.110 1.00 16.39  ? 31  LEU U N    1 
ATOM   139  C CA   . LEU A  1 31  ? 105.807 109.490 116.813 1.00 17.55  ? 31  LEU U CA   1 
ATOM   140  C C    . LEU A  1 31  ? 104.881 108.854 115.786 1.00 19.44  ? 31  LEU U C    1 
ATOM   141  O O    . LEU A  1 31  ? 104.796 109.320 114.643 1.00 25.50  ? 31  LEU U O    1 
ATOM   142  C CB   . LEU A  1 31  ? 107.092 108.675 116.944 1.00 15.56  ? 31  LEU U CB   1 
ATOM   143  C CG   . LEU A  1 31  ? 108.260 109.349 117.660 1.00 18.48  ? 31  LEU U CG   1 
ATOM   144  C CD1  . LEU A  1 31  ? 109.457 108.423 117.697 1.00 19.73  ? 31  LEU U CD1  1 
ATOM   145  C CD2  . LEU A  1 31  ? 108.613 110.650 116.974 1.00 18.02  ? 31  LEU U CD2  1 
ATOM   146  N N    . LEU A  1 32  ? 104.180 107.785 116.168 1.00 15.48  ? 32  LEU U N    1 
ATOM   147  C CA   . LEU A  1 32  ? 103.289 107.131 115.212 1.00 18.65  ? 32  LEU U CA   1 
ATOM   148  C C    . LEU A  1 32  ? 102.196 108.084 114.737 1.00 23.67  ? 32  LEU U C    1 
ATOM   149  O O    . LEU A  1 32  ? 101.933 108.205 113.529 1.00 25.59  ? 32  LEU U O    1 
ATOM   150  C CB   . LEU A  1 32  ? 102.680 105.874 115.832 1.00 19.60  ? 32  LEU U CB   1 
ATOM   151  C CG   . LEU A  1 32  ? 103.639 104.716 116.107 1.00 18.68  ? 32  LEU U CG   1 
ATOM   152  C CD1  . LEU A  1 32  ? 102.886 103.527 116.668 1.00 21.50  ? 32  LEU U CD1  1 
ATOM   153  C CD2  . LEU A  1 32  ? 104.384 104.328 114.846 1.00 19.75  ? 32  LEU U CD2  1 
ATOM   154  N N    . GLY A  1 33  ? 101.554 108.785 115.675 1.00 23.93  ? 33  GLY U N    1 
ATOM   155  C CA   . GLY A  1 33  ? 100.504 109.713 115.290 1.00 19.21  ? 33  GLY U CA   1 
ATOM   156  C C    . GLY A  1 33  ? 101.012 110.832 114.401 1.00 25.72  ? 33  GLY U C    1 
ATOM   157  O O    . GLY A  1 33  ? 100.377 111.186 113.399 1.00 28.82  ? 33  GLY U O    1 
ATOM   158  N N    . GLY A  1 34  ? 102.162 111.408 114.753 1.00 21.95  ? 34  GLY U N    1 
ATOM   159  C CA   . GLY A  1 34  ? 102.725 112.463 113.932 1.00 19.04  ? 34  GLY U CA   1 
ATOM   160  C C    . GLY A  1 34  ? 103.044 111.996 112.526 1.00 22.99  ? 34  GLY U C    1 
ATOM   161  O O    . GLY A  1 34  ? 102.801 112.714 111.554 1.00 28.58  ? 34  GLY U O    1 
ATOM   162  N N    . ALA A  1 35  ? 103.604 110.792 112.400 1.00 18.55  ? 35  ALA U N    1 
ATOM   163  C CA   . ALA A  1 35  ? 103.906 110.265 111.074 1.00 17.78  ? 35  ALA U CA   1 
ATOM   164  C C    . ALA A  1 35  ? 102.638 110.128 110.246 1.00 20.26  ? 35  ALA U C    1 
ATOM   165  O O    . ALA A  1 35  ? 102.598 110.525 109.073 1.00 21.41  ? 35  ALA U O    1 
ATOM   166  C CB   . ALA A  1 35  ? 104.618 108.920 111.192 1.00 15.61  ? 35  ALA U CB   1 
ATOM   167  N N    . ALA A  1 36  ? 101.582 109.574 110.844 1.00 24.22  ? 36  ALA U N    1 
ATOM   168  C CA   . ALA A  1 36  ? 100.332 109.426 110.105 1.00 19.42  ? 36  ALA U CA   1 
ATOM   169  C C    . ALA A  1 36  ? 99.822  110.779 109.622 1.00 25.75  ? 36  ALA U C    1 
ATOM   170  O O    . ALA A  1 36  ? 99.466  110.944 108.446 1.00 28.08  ? 36  ALA U O    1 
ATOM   171  C CB   . ALA A  1 36  ? 99.286  108.733 110.972 1.00 22.29  ? 36  ALA U CB   1 
ATOM   172  N N    . VAL A  1 37  ? 99.799  111.769 110.518 1.00 29.56  ? 37  VAL U N    1 
ATOM   173  C CA   . VAL A  1 37  ? 99.250  113.075 110.159 1.00 25.58  ? 37  VAL U CA   1 
ATOM   174  C C    . VAL A  1 37  ? 100.073 113.720 109.049 1.00 24.97  ? 37  VAL U C    1 
ATOM   175  O O    . VAL A  1 37  ? 99.528  114.263 108.080 1.00 29.03  ? 37  VAL U O    1 
ATOM   176  C CB   . VAL A  1 37  ? 99.164  113.984 111.396 1.00 24.01  ? 37  VAL U CB   1 
ATOM   177  C CG1  . VAL A  1 37  ? 98.789  115.388 110.981 1.00 26.26  ? 37  VAL U CG1  1 
ATOM   178  C CG2  . VAL A  1 37  ? 98.150  113.436 112.379 1.00 23.89  ? 37  VAL U CG2  1 
ATOM   179  N N    . PHE A  1 38  ? 101.401 113.683 109.179 1.00 26.03  ? 38  PHE U N    1 
ATOM   180  C CA   . PHE A  1 38  ? 102.245 114.331 108.180 1.00 20.23  ? 38  PHE U CA   1 
ATOM   181  C C    . PHE A  1 38  ? 102.098 113.676 106.816 1.00 25.81  ? 38  PHE U C    1 
ATOM   182  O O    . PHE A  1 38  ? 102.036 114.369 105.791 1.00 27.73  ? 38  PHE U O    1 
ATOM   183  C CB   . PHE A  1 38  ? 103.704 114.315 108.625 1.00 13.33  ? 38  PHE U CB   1 
ATOM   184  C CG   . PHE A  1 38  ? 104.095 115.501 109.450 1.00 21.63  ? 38  PHE U CG   1 
ATOM   185  C CD1  . PHE A  1 38  ? 104.197 116.753 108.875 1.00 21.49  ? 38  PHE U CD1  1 
ATOM   186  C CD2  . PHE A  1 38  ? 104.369 115.366 110.797 1.00 24.34  ? 38  PHE U CD2  1 
ATOM   187  C CE1  . PHE A  1 38  ? 104.558 117.844 109.628 1.00 22.92  ? 38  PHE U CE1  1 
ATOM   188  C CE2  . PHE A  1 38  ? 104.731 116.455 111.554 1.00 17.80  ? 38  PHE U CE2  1 
ATOM   189  C CZ   . PHE A  1 38  ? 104.827 117.695 110.969 1.00 19.75  ? 38  PHE U CZ   1 
ATOM   190  N N    . SER A  1 39  ? 102.059 112.343 106.770 1.00 24.94  ? 39  SER U N    1 
ATOM   191  C CA   . SER A  1 39  ? 101.855 111.684 105.487 1.00 24.27  ? 39  SER U CA   1 
ATOM   192  C C    . SER A  1 39  ? 100.532 112.117 104.875 1.00 28.42  ? 39  SER U C    1 
ATOM   193  O O    . SER A  1 39  ? 100.466 112.481 103.692 1.00 35.29  ? 39  SER U O    1 
ATOM   194  C CB   . SER A  1 39  ? 101.897 110.167 105.655 1.00 25.94  ? 39  SER U CB   1 
ATOM   195  O OG   . SER A  1 39  ? 100.698 109.691 106.235 1.00 34.73  ? 39  SER U OG   1 
ATOM   196  N N    . ALA A  1 40  ? 99.466  112.119 105.683 1.00 29.29  ? 40  ALA U N    1 
ATOM   197  C CA   . ALA A  1 40  ? 98.161  112.521 105.170 1.00 26.51  ? 40  ALA U CA   1 
ATOM   198  C C    . ALA A  1 40  ? 98.198  113.937 104.615 1.00 26.22  ? 40  ALA U C    1 
ATOM   199  O O    . ALA A  1 40  ? 97.514  114.244 103.633 1.00 31.74  ? 40  ALA U O    1 
ATOM   200  C CB   . ALA A  1 40  ? 97.108  112.406 106.270 1.00 25.88  ? 40  ALA U CB   1 
ATOM   201  N N    . LEU A  1 41  ? 98.983  114.817 105.234 1.00 28.45  ? 41  LEU U N    1 
ATOM   202  C CA   . LEU A  1 41  ? 99.038  116.199 104.767 1.00 21.31  ? 41  LEU U CA   1 
ATOM   203  C C    . LEU A  1 41  ? 99.880  116.372 103.506 1.00 28.69  ? 41  LEU U C    1 
ATOM   204  O O    . LEU A  1 41  ? 99.565  117.235 102.679 1.00 31.40  ? 41  LEU U O    1 
ATOM   205  C CB   . LEU A  1 41  ? 99.578  117.112 105.869 1.00 22.20  ? 41  LEU U CB   1 
ATOM   206  C CG   . LEU A  1 41  ? 98.638  117.443 107.028 1.00 23.22  ? 41  LEU U CG   1 
ATOM   207  C CD1  . LEU A  1 41  ? 99.335  118.334 108.034 1.00 22.26  ? 41  LEU U CD1  1 
ATOM   208  C CD2  . LEU A  1 41  ? 97.377  118.106 106.515 1.00 21.74  ? 41  LEU U CD2  1 
ATOM   209  N N    . GLU A  1 42  ? 100.943 115.582 103.331 1.00 35.69  ? 42  GLU U N    1 
ATOM   210  C CA   . GLU A  1 42  ? 101.949 115.898 102.322 1.00 27.14  ? 42  GLU U CA   1 
ATOM   211  C C    . GLU A  1 42  ? 101.979 114.981 101.102 1.00 31.09  ? 42  GLU U C    1 
ATOM   212  O O    . GLU A  1 42  ? 102.599 115.353 100.095 1.00 38.35  ? 42  GLU U O    1 
ATOM   213  C CB   . GLU A  1 42  ? 103.345 115.889 102.962 1.00 30.11  ? 42  GLU U CB   1 
ATOM   214  C CG   . GLU A  1 42  ? 103.518 116.886 104.087 1.00 24.31  ? 42  GLU U CG   1 
ATOM   215  C CD   . GLU A  1 42  ? 103.725 118.294 103.583 1.00 34.71  ? 42  GLU U CD   1 
ATOM   216  O OE1  . GLU A  1 42  ? 103.756 118.484 102.351 1.00 44.20  ? 42  GLU U OE1  1 
ATOM   217  O OE2  . GLU A  1 42  ? 103.862 119.211 104.415 1.00 40.12  ? 42  GLU U OE2  1 
ATOM   218  N N    . LEU A  1 43  ? 101.353 113.801 101.160 1.00 30.46  ? 43  LEU U N    1 
ATOM   219  C CA   . LEU A  1 43  ? 101.551 112.829 100.086 1.00 31.98  ? 43  LEU U CA   1 
ATOM   220  C C    . LEU A  1 43  ? 101.052 113.349 98.741  1.00 37.33  ? 43  LEU U C    1 
ATOM   221  O O    . LEU A  1 43  ? 101.725 113.182 97.714  1.00 42.57  ? 43  LEU U O    1 
ATOM   222  C CB   . LEU A  1 43  ? 100.861 111.515 100.443 1.00 36.61  ? 43  LEU U CB   1 
ATOM   223  C CG   . LEU A  1 43  ? 101.153 110.348 99.504  1.00 35.57  ? 43  LEU U CG   1 
ATOM   224  C CD1  . LEU A  1 43  ? 102.648 110.123 99.402  1.00 35.64  ? 43  LEU U CD1  1 
ATOM   225  C CD2  . LEU A  1 43  ? 100.458 109.095 99.993  1.00 35.43  ? 43  LEU U CD2  1 
ATOM   226  N N    . ALA A  1 44  ? 99.866  113.960 98.719  1.00 37.81  ? 44  ALA U N    1 
ATOM   227  C CA   . ALA A  1 44  ? 99.301  114.417 97.453  1.00 35.37  ? 44  ALA U CA   1 
ATOM   228  C C    . ALA A  1 44  ? 100.171 115.490 96.815  1.00 44.06  ? 44  ALA U C    1 
ATOM   229  O O    . ALA A  1 44  ? 100.412 115.469 95.600  1.00 50.82  ? 44  ALA U O    1 
ATOM   230  C CB   . ALA A  1 44  ? 97.881  114.935 97.668  1.00 39.18  ? 44  ALA U CB   1 
ATOM   231  N N    . HIS A  1 45  ? 100.651 116.441 97.618  1.00 42.55  ? 45  HIS U N    1 
ATOM   232  C CA   . HIS A  1 45  ? 101.525 117.476 97.085  1.00 40.82  ? 45  HIS U CA   1 
ATOM   233  C C    . HIS A  1 45  ? 102.805 116.874 96.529  1.00 46.14  ? 45  HIS U C    1 
ATOM   234  O O    . HIS A  1 45  ? 103.281 117.282 95.462  1.00 50.96  ? 45  HIS U O    1 
ATOM   235  C CB   . HIS A  1 45  ? 101.842 118.505 98.167  1.00 44.64  ? 45  HIS U CB   1 
ATOM   236  C CG   . HIS A  1 45  ? 102.649 119.666 97.678  1.00 50.34  ? 45  HIS U CG   1 
ATOM   237  N ND1  . HIS A  1 45  ? 102.106 120.691 96.935  1.00 51.39  ? 45  HIS U ND1  1 
ATOM   238  C CD2  . HIS A  1 45  ? 103.961 119.965 97.826  1.00 48.11  ? 45  HIS U CD2  1 
ATOM   239  C CE1  . HIS A  1 45  ? 103.047 121.571 96.646  1.00 47.67  ? 45  HIS U CE1  1 
ATOM   240  N NE2  . HIS A  1 45  ? 104.182 121.155 97.175  1.00 45.42  ? 45  HIS U NE2  1 
ATOM   241  N N    . GLU A  1 46  ? 103.381 115.896 97.235  1.00 43.55  ? 46  GLU U N    1 
ATOM   242  C CA   . GLU A  1 46  ? 104.601 115.272 96.732  1.00 39.64  ? 46  GLU U CA   1 
ATOM   243  C C    . GLU A  1 46  ? 104.360 114.611 95.380  1.00 38.22  ? 46  GLU U C    1 
ATOM   244  O O    . GLU A  1 46  ? 105.149 114.778 94.439  1.00 44.54  ? 46  GLU U O    1 
ATOM   245  C CB   . GLU A  1 46  ? 105.128 114.251 97.736  1.00 44.03  ? 46  GLU U CB   1 
ATOM   246  C CG   . GLU A  1 46  ? 106.467 113.660 97.348  1.00 46.51  ? 46  GLU U CG   1 
ATOM   247  C CD   . GLU A  1 46  ? 106.642 112.242 97.836  1.00 49.76  ? 46  GLU U CD   1 
ATOM   248  O OE1  . GLU A  1 46  ? 105.621 111.568 98.080  1.00 50.04  ? 46  GLU U OE1  1 
ATOM   249  O OE2  . GLU A  1 46  ? 107.799 111.799 97.978  1.00 49.20  ? 46  GLU U OE2  1 
ATOM   250  N N    . ARG A  1 47  ? 103.268 113.852 95.264  1.00 39.62  ? 47  ARG U N    1 
ATOM   251  C CA   . ARG A  1 47  ? 102.981 113.181 94.001  1.00 42.86  ? 47  ARG U CA   1 
ATOM   252  C C    . ARG A  1 47  ? 102.780 114.188 92.876  1.00 47.07  ? 47  ARG U C    1 
ATOM   253  O O    . ARG A  1 47  ? 103.283 113.999 91.759  1.00 51.96  ? 47  ARG U O    1 
ATOM   254  C CB   . ARG A  1 47  ? 101.750 112.288 94.137  1.00 44.75  ? 47  ARG U CB   1 
ATOM   255  C CG   . ARG A  1 47  ? 101.993 110.997 94.891  1.00 47.74  ? 47  ARG U CG   1 
ATOM   256  C CD   . ARG A  1 47  ? 100.885 109.996 94.609  1.00 50.82  ? 47  ARG U CD   1 
ATOM   257  N NE   . ARG A  1 47  ? 101.123 108.712 95.252  1.00 54.20  ? 47  ARG U NE   1 
ATOM   258  C CZ   . ARG A  1 47  ? 100.531 108.313 96.369  1.00 54.74  ? 47  ARG U CZ   1 
ATOM   259  N NH1  . ARG A  1 47  ? 99.647  109.075 96.991  1.00 51.45  ? 47  ARG U NH1  1 
ATOM   260  N NH2  . ARG A  1 47  ? 100.828 107.118 96.870  1.00 51.68  ? 47  ARG U NH2  1 
ATOM   261  N N    . GLN A  1 48  ? 102.041 115.264 93.147  1.00 48.63  ? 48  GLN U N    1 
ATOM   262  C CA   . GLN A  1 48  ? 101.796 116.261 92.112  1.00 48.10  ? 48  GLN U CA   1 
ATOM   263  C C    . GLN A  1 48  ? 103.095 116.915 91.659  1.00 49.22  ? 48  GLN U C    1 
ATOM   264  O O    . GLN A  1 48  ? 103.309 117.123 90.458  1.00 52.11  ? 48  GLN U O    1 
ATOM   265  C CB   . GLN A  1 48  ? 100.810 117.308 92.622  1.00 49.84  ? 48  GLN U CB   1 
ATOM   266  C CG   . GLN A  1 48  ? 100.304 118.255 91.556  1.00 52.81  ? 48  GLN U CG   1 
ATOM   267  C CD   . GLN A  1 48  ? 99.201  119.157 92.065  1.00 58.95  ? 48  GLN U CD   1 
ATOM   268  O OE1  . GLN A  1 48  ? 98.728  119.002 93.192  1.00 58.27  ? 48  GLN U OE1  1 
ATOM   269  N NE2  . GLN A  1 48  ? 98.783  120.108 91.239  1.00 56.91  ? 48  GLN U NE2  1 
ATOM   270  N N    . ALA A  1 49  ? 103.977 117.245 92.604  1.00 47.55  ? 49  ALA U N    1 
ATOM   271  C CA   . ALA A  1 49  ? 105.253 117.849 92.236  1.00 44.25  ? 49  ALA U CA   1 
ATOM   272  C C    . ALA A  1 49  ? 106.088 116.901 91.387  1.00 47.20  ? 49  ALA U C    1 
ATOM   273  O O    . ALA A  1 49  ? 106.707 117.320 90.399  1.00 48.07  ? 49  ALA U O    1 
ATOM   274  C CB   . ALA A  1 49  ? 106.021 118.264 93.488  1.00 43.75  ? 49  ALA U CB   1 
ATOM   275  N N    . LYS A  1 50  ? 106.132 115.620 91.762  1.00 47.15  ? 50  LYS U N    1 
ATOM   276  C CA   . LYS A  1 50  ? 106.895 114.665 90.966  1.00 42.90  ? 50  LYS U CA   1 
ATOM   277  C C    . LYS A  1 50  ? 106.345 114.568 89.551  1.00 44.41  ? 50  LYS U C    1 
ATOM   278  O O    . LYS A  1 50  ? 107.109 114.541 88.577  1.00 51.01  ? 50  LYS U O    1 
ATOM   279  C CB   . LYS A  1 50  ? 106.892 113.292 91.636  1.00 43.51  ? 50  LYS U CB   1 
ATOM   280  C CG   . LYS A  1 50  ? 107.705 113.217 92.915  1.00 43.69  ? 50  LYS U CG   1 
ATOM   281  C CD   . LYS A  1 50  ? 107.763 111.794 93.438  1.00 46.84  ? 50  LYS U CD   1 
ATOM   282  C CE   . LYS A  1 50  ? 108.468 111.722 94.780  1.00 47.21  ? 50  LYS U CE   1 
ATOM   283  N NZ   . LYS A  1 50  ? 109.872 112.202 94.696  1.00 46.36  ? 50  LYS U NZ   1 
ATOM   284  N N    . GLN A  1 51  ? 105.019 114.517 89.414  1.00 46.70  ? 51  GLN U N    1 
ATOM   285  C CA   . GLN A  1 51  ? 104.430 114.443 88.081  1.00 46.26  ? 51  GLN U CA   1 
ATOM   286  C C    . GLN A  1 51  ? 104.766 115.680 87.259  1.00 48.57  ? 51  GLN U C    1 
ATOM   287  O O    . GLN A  1 51  ? 105.080 115.579 86.066  1.00 52.46  ? 51  GLN U O    1 
ATOM   288  C CB   . GLN A  1 51  ? 102.917 114.264 88.184  1.00 48.71  ? 51  GLN U CB   1 
ATOM   289  C CG   . GLN A  1 51  ? 102.211 114.247 86.844  1.00 52.52  ? 51  GLN U CG   1 
ATOM   290  C CD   . GLN A  1 51  ? 100.709 114.120 86.984  1.00 56.98  ? 51  GLN U CD   1 
ATOM   291  O OE1  . GLN A  1 51  ? 100.188 113.974 88.089  1.00 57.60  ? 51  GLN U OE1  1 
ATOM   292  N NE2  . GLN A  1 51  ? 100.003 114.176 85.861  1.00 51.71  ? 51  GLN U NE2  1 
ATOM   293  N N    . ARG A  1 52  ? 104.695 116.861 87.878  1.00 50.07  ? 52  ARG U N    1 
ATOM   294  C CA   . ARG A  1 52  ? 105.010 118.083 87.147  1.00 48.15  ? 52  ARG U CA   1 
ATOM   295  C C    . ARG A  1 52  ? 106.460 118.092 86.682  1.00 49.05  ? 52  ARG U C    1 
ATOM   296  O O    . ARG A  1 52  ? 106.753 118.478 85.543  1.00 51.30  ? 52  ARG U O    1 
ATOM   297  C CB   . ARG A  1 52  ? 104.712 119.309 88.009  1.00 46.10  ? 52  ARG U CB   1 
ATOM   298  C CG   . ARG A  1 52  ? 105.114 120.618 87.361  1.00 45.65  ? 52  ARG U CG   1 
ATOM   299  C CD   . ARG A  1 52  ? 104.387 121.804 87.973  1.00 48.88  ? 52  ARG U CD   1 
ATOM   300  N NE   . ARG A  1 52  ? 104.557 121.878 89.419  1.00 53.75  ? 52  ARG U NE   1 
ATOM   301  C CZ   . ARG A  1 52  ? 103.611 121.580 90.299  1.00 53.83  ? 52  ARG U CZ   1 
ATOM   302  N NH1  . ARG A  1 52  ? 102.407 121.190 89.914  1.00 49.69  ? 52  ARG U NH1  1 
ATOM   303  N NH2  . ARG A  1 52  ? 103.876 121.683 91.598  1.00 50.93  ? 52  ARG U NH2  1 
ATOM   304  N N    . TRP A  1 53  ? 107.386 117.671 87.547  1.00 49.22  ? 53  TRP U N    1 
ATOM   305  C CA   . TRP A  1 53  ? 108.784 117.613 87.130  1.00 44.77  ? 53  TRP U CA   1 
ATOM   306  C C    . TRP A  1 53  ? 108.977 116.633 85.984  1.00 44.16  ? 53  TRP U C    1 
ATOM   307  O O    . TRP A  1 53  ? 109.735 116.903 85.046  1.00 48.79  ? 53  TRP U O    1 
ATOM   308  C CB   . TRP A  1 53  ? 109.692 117.226 88.292  1.00 44.94  ? 53  TRP U CB   1 
ATOM   309  C CG   . TRP A  1 53  ? 110.953 116.571 87.812  1.00 43.67  ? 53  TRP U CG   1 
ATOM   310  C CD1  . TRP A  1 53  ? 111.303 115.265 87.962  1.00 45.69  ? 53  TRP U CD1  1 
ATOM   311  C CD2  . TRP A  1 53  ? 112.012 117.188 87.071  1.00 44.32  ? 53  TRP U CD2  1 
ATOM   312  N NE1  . TRP A  1 53  ? 112.521 115.030 87.376  1.00 44.13  ? 53  TRP U NE1  1 
ATOM   313  C CE2  . TRP A  1 53  ? 112.978 116.196 86.821  1.00 43.61  ? 53  TRP U CE2  1 
ATOM   314  C CE3  . TRP A  1 53  ? 112.242 118.483 86.601  1.00 44.81  ? 53  TRP U CE3  1 
ATOM   315  C CZ2  . TRP A  1 53  ? 114.153 116.457 86.123  1.00 43.67  ? 53  TRP U CZ2  1 
ATOM   316  C CZ3  . TRP A  1 53  ? 113.409 118.741 85.910  1.00 43.82  ? 53  TRP U CZ3  1 
ATOM   317  C CH2  . TRP A  1 53  ? 114.349 117.734 85.677  1.00 40.37  ? 53  TRP U CH2  1 
ATOM   318  N N    . GLU A  1 54  ? 108.324 115.472 86.056  1.00 53.10  ? 54  GLU U N    1 
ATOM   319  C CA   . GLU A  1 54  ? 108.455 114.504 84.973  1.00 51.76  ? 54  GLU U CA   1 
ATOM   320  C C    . GLU A  1 54  ? 107.964 115.092 83.660  1.00 54.00  ? 54  GLU U C    1 
ATOM   321  O O    . GLU A  1 54  ? 108.604 114.922 82.613  1.00 54.94  ? 54  GLU U O    1 
ATOM   322  C CB   . GLU A  1 54  ? 107.686 113.229 85.310  1.00 52.29  ? 54  GLU U CB   1 
ATOM   323  C CG   . GLU A  1 54  ? 107.595 112.253 84.156  1.00 56.95  ? 54  GLU U CG   1 
ATOM   324  C CD   . GLU A  1 54  ? 108.956 111.789 83.687  1.00 63.52  ? 54  GLU U CD   1 
ATOM   325  O OE1  . GLU A  1 54  ? 109.919 111.889 84.474  1.00 63.07  ? 54  GLU U OE1  1 
ATOM   326  O OE2  . GLU A  1 54  ? 109.063 111.326 82.532  1.00 62.64  ? 54  GLU U OE2  1 
ATOM   327  N N    . GLU A  1 55  ? 106.829 115.791 83.694  1.00 60.04  ? 55  GLU U N    1 
ATOM   328  C CA   . GLU A  1 55  ? 106.316 116.404 82.474  1.00 57.96  ? 55  GLU U CA   1 
ATOM   329  C C    . GLU A  1 55  ? 107.280 117.452 81.932  1.00 59.18  ? 55  GLU U C    1 
ATOM   330  O O    . GLU A  1 55  ? 107.520 117.519 80.721  1.00 57.73  ? 55  GLU U O    1 
ATOM   331  C CB   . GLU A  1 55  ? 104.943 117.023 82.729  1.00 57.41  ? 55  GLU U CB   1 
ATOM   332  C CG   . GLU A  1 55  ? 104.394 117.785 81.540  1.00 62.32  ? 55  GLU U CG   1 
ATOM   333  C CD   . GLU A  1 55  ? 104.349 116.944 80.279  1.00 66.59  ? 55  GLU U CD   1 
ATOM   334  O OE1  . GLU A  1 55  ? 104.511 115.710 80.379  1.00 67.94  ? 55  GLU U OE1  1 
ATOM   335  O OE2  . GLU A  1 55  ? 104.152 117.517 79.187  1.00 65.29  ? 55  GLU U OE2  1 
ATOM   336  N N    . ARG A  1 56  ? 107.842 118.281 82.815  1.00 59.13  ? 56  ARG U N    1 
ATOM   337  C CA   . ARG A  1 56  ? 108.785 119.302 82.361  1.00 52.83  ? 56  ARG U CA   1 
ATOM   338  C C    . ARG A  1 56  ? 110.014 118.672 81.720  1.00 55.87  ? 56  ARG U C    1 
ATOM   339  O O    . ARG A  1 56  ? 110.481 119.131 80.671  1.00 56.88  ? 56  ARG U O    1 
ATOM   340  C CB   . ARG A  1 56  ? 109.195 120.199 83.525  1.00 49.27  ? 56  ARG U CB   1 
ATOM   341  C CG   . ARG A  1 56  ? 108.118 121.160 83.977  1.00 51.89  ? 56  ARG U CG   1 
ATOM   342  C CD   . ARG A  1 56  ? 108.539 121.889 85.235  1.00 53.42  ? 56  ARG U CD   1 
ATOM   343  N NE   . ARG A  1 56  ? 107.548 122.871 85.653  1.00 54.51  ? 56  ARG U NE   1 
ATOM   344  C CZ   . ARG A  1 56  ? 107.588 123.530 86.802  1.00 55.84  ? 56  ARG U CZ   1 
ATOM   345  N NH1  . ARG A  1 56  ? 108.553 123.325 87.682  1.00 54.50  ? 56  ARG U NH1  1 
ATOM   346  N NH2  . ARG A  1 56  ? 106.634 124.415 87.075  1.00 56.37  ? 56  ARG U NH2  1 
ATOM   347  N N    . LEU A  1 57  ? 110.561 117.629 82.344  1.00 55.00  ? 57  LEU U N    1 
ATOM   348  C CA   . LEU A  1 57  ? 111.733 116.968 81.781  1.00 52.31  ? 57  LEU U CA   1 
ATOM   349  C C    . LEU A  1 57  ? 111.417 116.355 80.424  1.00 56.24  ? 57  LEU U C    1 
ATOM   350  O O    . LEU A  1 57  ? 112.202 116.482 79.476  1.00 56.70  ? 57  LEU U O    1 
ATOM   351  C CB   . LEU A  1 57  ? 112.246 115.899 82.742  1.00 49.18  ? 57  LEU U CB   1 
ATOM   352  C CG   . LEU A  1 57  ? 113.303 114.947 82.188  1.00 51.00  ? 57  LEU U CG   1 
ATOM   353  C CD1  . LEU A  1 57  ? 114.543 115.709 81.775  1.00 54.74  ? 57  LEU U CD1  1 
ATOM   354  C CD2  . LEU A  1 57  ? 113.643 113.883 83.211  1.00 54.86  ? 57  LEU U CD2  1 
ATOM   355  N N    . ALA A  1 58  ? 110.264 115.691 80.307  1.00 63.53  ? 58  ALA U N    1 
ATOM   356  C CA   . ALA A  1 58  ? 109.892 115.099 79.029  1.00 63.07  ? 58  ALA U CA   1 
ATOM   357  C C    . ALA A  1 58  ? 109.750 116.166 77.954  1.00 64.02  ? 58  ALA U C    1 
ATOM   358  O O    . ALA A  1 58  ? 110.195 115.977 76.817  1.00 61.78  ? 58  ALA U O    1 
ATOM   359  C CB   . ALA A  1 58  ? 108.597 114.305 79.172  1.00 64.16  ? 58  ALA U CB   1 
ATOM   360  N N    . GLN A  1 59  ? 109.129 117.298 78.293  1.00 69.35  ? 59  GLN U N    1 
ATOM   361  C CA   . GLN A  1 59  ? 108.967 118.364 77.311  1.00 68.14  ? 59  GLN U CA   1 
ATOM   362  C C    . GLN A  1 59  ? 110.313 118.936 76.888  1.00 69.13  ? 59  GLN U C    1 
ATOM   363  O O    . GLN A  1 59  ? 110.546 119.176 75.698  1.00 69.42  ? 59  GLN U O    1 
ATOM   364  C CB   . GLN A  1 59  ? 108.072 119.466 77.873  1.00 69.06  ? 59  GLN U CB   1 
ATOM   365  C CG   . GLN A  1 59  ? 107.935 120.664 76.954  1.00 71.78  ? 59  GLN U CG   1 
ATOM   366  C CD   . GLN A  1 59  ? 107.427 120.287 75.579  1.00 75.31  ? 59  GLN U CD   1 
ATOM   367  O OE1  . GLN A  1 59  ? 106.950 119.172 75.365  1.00 72.53  ? 59  GLN U OE1  1 
ATOM   368  N NE2  . GLN A  1 59  ? 107.528 121.215 74.636  1.00 72.16  ? 59  GLN U NE2  1 
ATOM   369  N N    . PHE A  1 60  ? 111.212 119.165 77.846  1.00 67.72  ? 60  PHE U N    1 
ATOM   370  C CA   . PHE A  1 60  ? 112.519 119.718 77.504  1.00 65.65  ? 60  PHE U CA   1 
ATOM   371  C C    . PHE A  1 60  ? 113.307 118.764 76.618  1.00 64.44  ? 60  PHE U C    1 
ATOM   372  O O    . PHE A  1 60  ? 113.954 119.190 75.656  1.00 61.26  ? 60  PHE U O    1 
ATOM   373  C CB   . PHE A  1 60  ? 113.306 120.042 78.773  1.00 63.95  ? 60  PHE U CB   1 
ATOM   374  C CG   . PHE A  1 60  ? 114.657 120.647 78.512  1.00 63.08  ? 60  PHE U CG   1 
ATOM   375  C CD1  . PHE A  1 60  ? 114.793 122.008 78.310  1.00 62.12  ? 60  PHE U CD1  1 
ATOM   376  C CD2  . PHE A  1 60  ? 115.789 119.856 78.476  1.00 64.40  ? 60  PHE U CD2  1 
ATOM   377  C CE1  . PHE A  1 60  ? 116.032 122.566 78.073  1.00 58.76  ? 60  PHE U CE1  1 
ATOM   378  C CE2  . PHE A  1 60  ? 117.030 120.412 78.239  1.00 60.21  ? 60  PHE U CE2  1 
ATOM   379  C CZ   . PHE A  1 60  ? 117.150 121.767 78.037  1.00 56.89  ? 60  PHE U CZ   1 
ATOM   380  N N    . SER A  1 61  ? 113.265 117.466 76.926  1.00 72.84  ? 61  SER U N    1 
ATOM   381  C CA   . SER A  1 61  ? 114.018 116.502 76.129  1.00 71.15  ? 61  SER U CA   1 
ATOM   382  C C    . SER A  1 61  ? 113.541 116.483 74.684  1.00 72.53  ? 61  SER U C    1 
ATOM   383  O O    . SER A  1 61  ? 114.355 116.427 73.755  1.00 69.70  ? 61  SER U O    1 
ATOM   384  C CB   . SER A  1 61  ? 113.906 115.110 76.746  1.00 70.39  ? 61  SER U CB   1 
ATOM   385  O OG   . SER A  1 61  ? 114.473 114.136 75.890  1.00 72.26  ? 61  SER U OG   1 
ATOM   386  N N    . ARG A  1 62  ? 112.225 116.517 74.472  1.00 79.61  ? 62  ARG U N    1 
ATOM   387  C CA   . ARG A  1 62  ? 111.692 116.438 73.116  1.00 80.28  ? 62  ARG U CA   1 
ATOM   388  C C    . ARG A  1 62  ? 112.090 117.652 72.286  1.00 80.28  ? 62  ARG U C    1 
ATOM   389  O O    . ARG A  1 62  ? 112.431 117.518 71.105  1.00 81.36  ? 62  ARG U O    1 
ATOM   390  C CB   . ARG A  1 62  ? 110.172 116.299 73.157  1.00 82.81  ? 62  ARG U CB   1 
ATOM   391  C CG   . ARG A  1 62  ? 109.529 116.159 71.790  1.00 81.18  ? 62  ARG U CG   1 
ATOM   392  C CD   . ARG A  1 62  ? 108.013 116.210 71.880  1.00 81.38  ? 62  ARG U CD   1 
ATOM   393  N NE   . ARG A  1 62  ? 107.492 115.269 72.864  1.00 82.56  ? 62  ARG U NE   1 
ATOM   394  C CZ   . ARG A  1 62  ? 107.145 115.596 74.101  1.00 83.31  ? 62  ARG U CZ   1 
ATOM   395  N NH1  . ARG A  1 62  ? 107.242 116.840 74.540  1.00 82.94  ? 62  ARG U NH1  1 
ATOM   396  N NH2  . ARG A  1 62  ? 106.688 114.652 74.919  1.00 81.04  ? 62  ARG U NH2  1 
ATOM   397  N N    . GLY A  1 63  ? 112.052 118.844 72.883  1.00 77.12  ? 63  GLY U N    1 
ATOM   398  C CA   . GLY A  1 63  ? 112.264 120.053 72.105  1.00 77.19  ? 63  GLY U CA   1 
ATOM   399  C C    . GLY A  1 63  ? 113.641 120.130 71.476  1.00 77.92  ? 63  GLY U C    1 
ATOM   400  O O    . GLY A  1 63  ? 113.780 120.498 70.307  1.00 78.82  ? 63  GLY U O    1 
ATOM   401  N N    . HIS A  1 64  ? 114.678 119.788 72.237  1.00 74.96  ? 64  HIS U N    1 
ATOM   402  C CA   . HIS A  1 64  ? 116.054 119.926 71.782  1.00 75.74  ? 64  HIS U CA   1 
ATOM   403  C C    . HIS A  1 64  ? 116.664 118.609 71.323  1.00 74.36  ? 64  HIS U C    1 
ATOM   404  O O    . HIS A  1 64  ? 117.868 118.558 71.050  1.00 72.96  ? 64  HIS U O    1 
ATOM   405  C CB   . HIS A  1 64  ? 116.909 120.546 72.887  1.00 76.54  ? 64  HIS U CB   1 
ATOM   406  C CG   . HIS A  1 64  ? 116.399 121.867 73.369  1.00 76.27  ? 64  HIS U CG   1 
ATOM   407  N ND1  . HIS A  1 64  ? 115.305 121.985 74.198  1.00 75.00  ? 64  HIS U ND1  1 
ATOM   408  C CD2  . HIS A  1 64  ? 116.827 123.129 73.131  1.00 75.30  ? 64  HIS U CD2  1 
ATOM   409  C CE1  . HIS A  1 64  ? 115.085 123.262 74.455  1.00 72.86  ? 64  HIS U CE1  1 
ATOM   410  N NE2  . HIS A  1 64  ? 115.995 123.977 73.820  1.00 74.56  ? 64  HIS U NE2  1 
ATOM   411  N N    . GLN A  1 65  ? 115.870 117.546 71.232  1.00 79.27  ? 65  GLN U N    1 
ATOM   412  C CA   . GLN A  1 65  ? 116.324 116.254 70.727  1.00 80.32  ? 65  GLN U CA   1 
ATOM   413  C C    . GLN A  1 65  ? 117.447 115.661 71.569  1.00 78.41  ? 65  GLN U C    1 
ATOM   414  O O    . GLN A  1 65  ? 118.253 114.871 71.067  1.00 75.01  ? 65  GLN U O    1 
ATOM   415  C CB   . GLN A  1 65  ? 116.764 116.361 69.264  1.00 78.30  ? 65  GLN U CB   1 
ATOM   416  C CG   . GLN A  1 65  ? 115.692 116.919 68.346  1.00 78.74  ? 65  GLN U CG   1 
ATOM   417  C CD   . GLN A  1 65  ? 116.147 117.009 66.906  1.00 82.08  ? 65  GLN U CD   1 
ATOM   418  O OE1  . GLN A  1 65  ? 117.242 116.567 66.560  1.00 82.86  ? 65  GLN U OE1  1 
ATOM   419  N NE2  . GLN A  1 65  ? 115.305 117.584 66.055  1.00 80.86  ? 65  GLN U NE2  1 
ATOM   420  N N    . LEU A  1 66  ? 117.522 116.027 72.844  1.00 77.08  ? 66  LEU U N    1 
ATOM   421  C CA   . LEU A  1 66  ? 118.522 115.462 73.737  1.00 75.41  ? 66  LEU U CA   1 
ATOM   422  C C    . LEU A  1 66  ? 118.083 114.092 74.230  1.00 74.96  ? 66  LEU U C    1 
ATOM   423  O O    . LEU A  1 66  ? 116.911 113.875 74.547  1.00 73.64  ? 66  LEU U O    1 
ATOM   424  C CB   . LEU A  1 66  ? 118.761 116.389 74.926  1.00 72.28  ? 66  LEU U CB   1 
ATOM   425  C CG   . LEU A  1 66  ? 119.269 117.789 74.591  1.00 73.74  ? 66  LEU U CG   1 
ATOM   426  C CD1  . LEU A  1 66  ? 119.435 118.603 75.858  1.00 74.31  ? 66  LEU U CD1  1 
ATOM   427  C CD2  . LEU A  1 66  ? 120.578 117.706 73.830  1.00 74.77  ? 66  LEU U CD2  1 
ATOM   428  N N    . SER A  1 67  ? 119.033 113.165 74.292  1.00 77.06  ? 67  SER U N    1 
ATOM   429  C CA   . SER A  1 67  ? 118.747 111.844 74.826  1.00 74.07  ? 67  SER U CA   1 
ATOM   430  C C    . SER A  1 67  ? 118.583 111.903 76.341  1.00 77.21  ? 67  SER U C    1 
ATOM   431  O O    . SER A  1 67  ? 119.049 112.828 77.011  1.00 79.26  ? 67  SER U O    1 
ATOM   432  C CB   . SER A  1 67  ? 119.858 110.863 74.459  1.00 74.55  ? 67  SER U CB   1 
ATOM   433  O OG   . SER A  1 67  ? 119.640 109.604 75.070  1.00 76.45  ? 67  SER U OG   1 
ATOM   434  N N    . ARG A  1 68  ? 117.933 110.903 76.914  1.00 75.90  ? 68  ARG U N    1 
ATOM   435  C CA   . ARG A  1 68  ? 117.721 111.008 78.374  1.00 75.24  ? 68  ARG U CA   1 
ATOM   436  C C    . ARG A  1 68  ? 119.031 110.699 79.109  1.00 75.70  ? 68  ARG U C    1 
ATOM   437  O O    . ARG A  1 68  ? 119.213 111.272 80.179  1.00 76.76  ? 68  ARG U O    1 
ATOM   438  C CB   . ARG A  1 68  ? 116.589 110.094 78.832  1.00 75.09  ? 68  ARG U CB   1 
ATOM   439  C CG   . ARG A  1 68  ? 115.667 110.738 79.854  1.00 75.32  ? 68  ARG U CG   1 
ATOM   440  C CD   . ARG A  1 68  ? 114.399 111.235 79.195  1.00 74.22  ? 68  ARG U CD   1 
ATOM   441  N NE   . ARG A  1 68  ? 113.242 111.008 80.044  1.00 74.73  ? 68  ARG U NE   1 
ATOM   442  C CZ   . ARG A  1 68  ? 111.986 111.091 79.631  1.00 75.12  ? 68  ARG U CZ   1 
ATOM   443  N NH1  . ARG A  1 68  ? 111.718 111.109 78.338  1.00 73.75  ? 68  ARG U NH1  1 
ATOM   444  N NH2  . ARG A  1 68  ? 111.003 111.158 80.512  1.00 73.28  ? 68  ARG U NH2  1 
ATOM   445  N N    . ASP A  1 69  ? 119.934 109.884 78.557  1.00 74.59  ? 69  ASP U N    1 
ATOM   446  C CA   . ASP A  1 69  ? 121.195 109.648 79.255  1.00 74.99  ? 69  ASP U CA   1 
ATOM   447  C C    . ASP A  1 69  ? 122.035 110.915 79.332  1.00 76.42  ? 69  ASP U C    1 
ATOM   448  O O    . ASP A  1 69  ? 122.699 111.169 80.345  1.00 77.50  ? 69  ASP U O    1 
ATOM   449  C CB   . ASP A  1 69  ? 121.974 108.530 78.563  1.00 76.49  ? 69  ASP U CB   1 
ATOM   450  C CG   . ASP A  1 69  ? 121.209 107.224 78.532  1.00 79.52  ? 69  ASP U CG   1 
ATOM   451  O OD1  . ASP A  1 69  ? 120.441 106.963 79.482  1.00 79.26  ? 69  ASP U OD1  1 
ATOM   452  O OD2  . ASP A  1 69  ? 121.376 106.459 77.560  1.00 79.07  ? 69  ASP U OD2  1 
ATOM   453  N N    . GLU A  1 70  ? 122.042 111.713 78.264  1.00 69.06  ? 70  GLU U N    1 
ATOM   454  C CA   . GLU A  1 70  ? 122.816 112.949 78.286  1.00 67.97  ? 70  GLU U CA   1 
ATOM   455  C C    . GLU A  1 70  ? 122.302 113.897 79.361  1.00 69.75  ? 70  GLU U C    1 
ATOM   456  O O    . GLU A  1 70  ? 123.090 114.487 80.113  1.00 70.77  ? 70  GLU U O    1 
ATOM   457  C CB   . GLU A  1 70  ? 122.774 113.615 76.912  1.00 67.71  ? 70  GLU U CB   1 
ATOM   458  C CG   . GLU A  1 70  ? 123.493 112.826 75.833  1.00 69.99  ? 70  GLU U CG   1 
ATOM   459  C CD   . GLU A  1 70  ? 123.377 113.467 74.469  1.00 72.77  ? 70  GLU U CD   1 
ATOM   460  O OE1  . GLU A  1 70  ? 122.583 114.420 74.324  1.00 75.93  ? 70  GLU U OE1  1 
ATOM   461  O OE2  . GLU A  1 70  ? 124.078 113.021 73.537  1.00 72.13  ? 70  GLU U OE2  1 
ATOM   462  N N    . LEU A  1 71  ? 120.980 114.048 79.457  1.00 62.11  ? 71  LEU U N    1 
ATOM   463  C CA   . LEU A  1 71  ? 120.414 114.889 80.503  1.00 60.15  ? 71  LEU U CA   1 
ATOM   464  C C    . LEU A  1 71  ? 120.700 114.312 81.882  1.00 58.14  ? 71  LEU U C    1 
ATOM   465  O O    . LEU A  1 71  ? 120.935 115.059 82.837  1.00 60.17  ? 71  LEU U O    1 
ATOM   466  C CB   . LEU A  1 71  ? 118.911 115.057 80.289  1.00 60.83  ? 71  LEU U CB   1 
ATOM   467  C CG   . LEU A  1 71  ? 118.503 115.796 79.016  1.00 61.86  ? 71  LEU U CG   1 
ATOM   468  C CD1  . LEU A  1 71  ? 116.994 115.932 78.941  1.00 62.08  ? 71  LEU U CD1  1 
ATOM   469  C CD2  . LEU A  1 71  ? 119.166 117.157 78.954  1.00 60.31  ? 71  LEU U CD2  1 
ATOM   470  N N    . ARG A  1 72  ? 120.683 112.985 82.007  1.00 57.74  ? 72  ARG U N    1 
ATOM   471  C CA   . ARG A  1 72  ? 121.013 112.364 83.285  1.00 59.25  ? 72  ARG U CA   1 
ATOM   472  C C    . ARG A  1 72  ? 122.433 112.711 83.708  1.00 61.35  ? 72  ARG U C    1 
ATOM   473  O O    . ARG A  1 72  ? 122.684 113.066 84.865  1.00 61.25  ? 72  ARG U O    1 
ATOM   474  C CB   . ARG A  1 72  ? 120.835 110.849 83.188  1.00 60.74  ? 72  ARG U CB   1 
ATOM   475  C CG   . ARG A  1 72  ? 119.410 110.407 82.926  1.00 65.34  ? 72  ARG U CG   1 
ATOM   476  C CD   . ARG A  1 72  ? 118.589 110.437 84.198  1.00 66.14  ? 72  ARG U CD   1 
ATOM   477  N NE   . ARG A  1 72  ? 119.198 109.620 85.239  1.00 67.11  ? 72  ARG U NE   1 
ATOM   478  C CZ   . ARG A  1 72  ? 119.106 108.299 85.301  1.00 66.25  ? 72  ARG U CZ   1 
ATOM   479  N NH1  . ARG A  1 72  ? 118.439 107.609 84.390  1.00 63.31  ? 72  ARG U NH1  1 
ATOM   480  N NH2  . ARG A  1 72  ? 119.703 107.653 86.298  1.00 65.91  ? 72  ARG U NH2  1 
ATOM   481  N N    . GLY A  1 73  ? 123.380 112.615 82.775  1.00 56.03  ? 73  GLY U N    1 
ATOM   482  C CA   . GLY A  1 73  ? 124.755 112.964 83.097  1.00 53.06  ? 73  GLY U CA   1 
ATOM   483  C C    . GLY A  1 73  ? 124.913 114.432 83.442  1.00 53.27  ? 73  GLY U C    1 
ATOM   484  O O    . GLY A  1 73  ? 125.629 114.789 84.383  1.00 53.76  ? 73  GLY U O    1 
ATOM   485  N N    . PHE A  1 74  ? 124.243 115.303 82.686  1.00 46.72  ? 74  PHE U N    1 
ATOM   486  C CA   . PHE A  1 74  ? 124.308 116.729 82.981  1.00 40.95  ? 74  PHE U CA   1 
ATOM   487  C C    . PHE A  1 74  ? 123.760 117.025 84.372  1.00 44.45  ? 74  PHE U C    1 
ATOM   488  O O    . PHE A  1 74  ? 124.349 117.808 85.127  1.00 41.61  ? 74  PHE U O    1 
ATOM   489  C CB   . PHE A  1 74  ? 123.541 117.513 81.918  1.00 38.51  ? 74  PHE U CB   1 
ATOM   490  C CG   . PHE A  1 74  ? 123.618 118.999 82.086  1.00 42.11  ? 74  PHE U CG   1 
ATOM   491  C CD1  . PHE A  1 74  ? 124.787 119.679 81.804  1.00 41.08  ? 74  PHE U CD1  1 
ATOM   492  C CD2  . PHE A  1 74  ? 122.519 119.718 82.515  1.00 42.01  ? 74  PHE U CD2  1 
ATOM   493  C CE1  . PHE A  1 74  ? 124.860 121.045 81.954  1.00 40.75  ? 74  PHE U CE1  1 
ATOM   494  C CE2  . PHE A  1 74  ? 122.588 121.085 82.666  1.00 41.55  ? 74  PHE U CE2  1 
ATOM   495  C CZ   . PHE A  1 74  ? 123.760 121.748 82.385  1.00 40.93  ? 74  PHE U CZ   1 
ATOM   496  N N    . LEU A  1 75  ? 122.641 116.398 84.734  1.00 46.15  ? 75  LEU U N    1 
ATOM   497  C CA   . LEU A  1 75  ? 122.064 116.620 86.054  1.00 42.07  ? 75  LEU U CA   1 
ATOM   498  C C    . LEU A  1 75  ? 122.940 116.045 87.157  1.00 45.29  ? 75  LEU U C    1 
ATOM   499  O O    . LEU A  1 75  ? 123.009 116.616 88.249  1.00 44.33  ? 75  LEU U O    1 
ATOM   500  C CB   . LEU A  1 75  ? 120.661 116.020 86.118  1.00 40.91  ? 75  LEU U CB   1 
ATOM   501  C CG   . LEU A  1 75  ? 119.635 116.656 85.184  1.00 38.22  ? 75  LEU U CG   1 
ATOM   502  C CD1  . LEU A  1 75  ? 118.297 115.959 85.315  1.00 39.45  ? 75  LEU U CD1  1 
ATOM   503  C CD2  . LEU A  1 75  ? 119.500 118.136 85.480  1.00 39.50  ? 75  LEU U CD2  1 
ATOM   504  N N    . ARG A  1 76  ? 123.607 114.919 86.903  1.00 46.27  ? 76  ARG U N    1 
ATOM   505  C CA   . ARG A  1 76  ? 124.545 114.388 87.888  1.00 41.79  ? 76  ARG U CA   1 
ATOM   506  C C    . ARG A  1 76  ? 125.694 115.358 88.122  1.00 44.65  ? 76  ARG U C    1 
ATOM   507  O O    . ARG A  1 76  ? 126.085 115.618 89.270  1.00 42.04  ? 76  ARG U O    1 
ATOM   508  C CB   . ARG A  1 76  ? 125.068 113.031 87.424  1.00 40.80  ? 76  ARG U CB   1 
ATOM   509  C CG   . ARG A  1 76  ? 125.767 112.229 88.499  1.00 47.87  ? 76  ARG U CG   1 
ATOM   510  C CD   . ARG A  1 76  ? 126.334 110.941 87.929  1.00 48.26  ? 76  ARG U CD   1 
ATOM   511  N NE   . ARG A  1 76  ? 125.344 110.207 87.152  1.00 46.65  ? 76  ARG U NE   1 
ATOM   512  C CZ   . ARG A  1 76  ? 124.504 109.315 87.660  1.00 48.18  ? 76  ARG U CZ   1 
ATOM   513  N NH1  . ARG A  1 76  ? 124.500 109.026 88.951  1.00 45.12  ? 76  ARG U NH1  1 
ATOM   514  N NH2  . ARG A  1 76  ? 123.647 108.698 86.852  1.00 47.53  ? 76  ARG U NH2  1 
ATOM   515  N N    . HIS A  1 77  ? 126.242 115.918 87.041  1.00 44.46  ? 77  HIS U N    1 
ATOM   516  C CA   . HIS A  1 77  ? 127.285 116.927 87.187  1.00 36.51  ? 77  HIS U CA   1 
ATOM   517  C C    . HIS A  1 77  ? 126.773 118.135 87.957  1.00 39.51  ? 77  HIS U C    1 
ATOM   518  O O    . HIS A  1 77  ? 127.486 118.694 88.800  1.00 40.49  ? 77  HIS U O    1 
ATOM   519  C CB   . HIS A  1 77  ? 127.807 117.350 85.816  1.00 37.39  ? 77  HIS U CB   1 
ATOM   520  C CG   . HIS A  1 77  ? 128.675 116.328 85.158  1.00 41.03  ? 77  HIS U CG   1 
ATOM   521  N ND1  . HIS A  1 77  ? 129.145 116.469 83.869  1.00 41.29  ? 77  HIS U ND1  1 
ATOM   522  C CD2  . HIS A  1 77  ? 129.166 115.150 85.609  1.00 41.83  ? 77  HIS U CD2  1 
ATOM   523  C CE1  . HIS A  1 77  ? 129.883 115.420 83.555  1.00 39.98  ? 77  HIS U CE1  1 
ATOM   524  N NE2  . HIS A  1 77  ? 129.912 114.605 84.593  1.00 43.22  ? 77  HIS U NE2  1 
ATOM   525  N N    . TYR A  1 78  ? 125.542 118.562 87.674  1.00 43.16  ? 78  TYR U N    1 
ATOM   526  C CA   . TYR A  1 78  ? 124.994 119.715 88.381  1.00 36.94  ? 78  TYR U CA   1 
ATOM   527  C C    . TYR A  1 78  ? 124.808 119.421 89.863  1.00 37.29  ? 78  TYR U C    1 
ATOM   528  O O    . TYR A  1 78  ? 125.022 120.300 90.700  1.00 49.40  ? 78  TYR U O    1 
ATOM   529  C CB   . TYR A  1 78  ? 123.671 120.156 87.764  1.00 42.04  ? 78  TYR U CB   1 
ATOM   530  C CG   . TYR A  1 78  ? 123.045 121.306 88.514  1.00 41.41  ? 78  TYR U CG   1 
ATOM   531  C CD1  . TYR A  1 78  ? 123.563 122.587 88.414  1.00 39.46  ? 78  TYR U CD1  1 
ATOM   532  C CD2  . TYR A  1 78  ? 121.947 121.109 89.335  1.00 38.27  ? 78  TYR U CD2  1 
ATOM   533  C CE1  . TYR A  1 78  ? 123.002 123.639 89.103  1.00 35.55  ? 78  TYR U CE1  1 
ATOM   534  C CE2  . TYR A  1 78  ? 121.379 122.156 90.026  1.00 42.09  ? 78  TYR U CE2  1 
ATOM   535  C CZ   . TYR A  1 78  ? 121.911 123.418 89.906  1.00 41.59  ? 78  TYR U CZ   1 
ATOM   536  O OH   . TYR A  1 78  ? 121.347 124.465 90.594  1.00 45.65  ? 78  TYR U OH   1 
ATOM   537  N N    . GLU A  1 79  ? 124.446 118.199 90.209  1.00 38.18  ? 79  GLU U N    1 
ATOM   538  C CA   . GLU A  1 79  ? 124.276 117.830 91.635  1.00 41.00  ? 79  GLU U CA   1 
ATOM   539  C C    . GLU A  1 79  ? 125.632 117.816 92.318  1.00 45.92  ? 79  GLU U C    1 
ATOM   540  O O    . GLU A  1 79  ? 125.695 118.178 93.484  1.00 48.47  ? 79  GLU U O    1 
ATOM   541  C CB   . GLU A  1 79  ? 123.694 116.436 91.778  1.00 43.38  ? 79  GLU U CB   1 
ATOM   542  C CG   . GLU A  1 79  ? 122.187 116.417 91.852  1.00 48.93  ? 79  GLU U CG   1 
ATOM   543  C CD   . GLU A  1 79  ? 121.632 115.085 92.318  1.00 50.98  ? 79  GLU U CD   1 
ATOM   544  O OE1  . GLU A  1 79  ? 122.425 114.143 92.476  1.00 49.83  ? 79  GLU U OE1  1 
ATOM   545  O OE2  . GLU A  1 79  ? 120.414 114.998 92.518  1.00 52.54  ? 79  GLU U OE2  1 
ATOM   546  N N    . GLU A  1 80  ? 126.663 117.356 91.622  1.00 47.52  ? 80  GLU U N    1 
ATOM   547  C CA   . GLU A  1 80  ? 128.005 117.411 92.189  1.00 42.25  ? 80  GLU U CA   1 
ATOM   548  C C    . GLU A  1 80  ? 128.447 118.852 92.406  1.00 41.48  ? 80  GLU U C    1 
ATOM   549  O O    . GLU A  1 80  ? 129.034 119.180 93.444  1.00 40.33  ? 80  GLU U O    1 
ATOM   550  C CB   . GLU A  1 80  ? 128.991 116.678 91.283  1.00 42.26  ? 80  GLU U CB   1 
ATOM   551  C CG   . GLU A  1 80  ? 130.430 116.765 91.746  1.00 43.76  ? 80  GLU U CG   1 
ATOM   552  C CD   . GLU A  1 80  ? 131.376 116.010 90.839  1.00 52.48  ? 80  GLU U CD   1 
ATOM   553  O OE1  . GLU A  1 80  ? 130.894 115.239 89.984  1.00 52.60  ? 80  GLU U OE1  1 
ATOM   554  O OE2  . GLU A  1 80  ? 132.603 116.188 90.978  1.00 54.36  ? 80  GLU U OE2  1 
ATOM   555  N N    . ALA A  1 81  ? 128.176 119.727 91.437  1.00 43.61  ? 81  ALA U N    1 
ATOM   556  C CA   . ALA A  1 81  ? 128.548 121.131 91.584  1.00 39.40  ? 81  ALA U CA   1 
ATOM   557  C C    . ALA A  1 81  ? 127.783 121.794 92.723  1.00 38.14  ? 81  ALA U C    1 
ATOM   558  O O    . ALA A  1 81  ? 128.367 122.520 93.533  1.00 43.32  ? 81  ALA U O    1 
ATOM   559  C CB   . ALA A  1 81  ? 128.309 121.879 90.274  1.00 35.17  ? 81  ALA U CB   1 
ATOM   560  N N    . THR A  1 82  ? 126.473 121.554 92.799  1.00 41.39  ? 82  THR U N    1 
ATOM   561  C CA   . THR A  1 82  ? 125.665 122.146 93.859  1.00 40.93  ? 82  THR U CA   1 
ATOM   562  C C    . THR A  1 82  ? 126.137 121.699 95.231  1.00 43.17  ? 82  THR U C    1 
ATOM   563  O O    . THR A  1 82  ? 126.051 122.463 96.198  1.00 41.05  ? 82  THR U O    1 
ATOM   564  C CB   . THR A  1 82  ? 124.194 121.780 93.670  1.00 40.54  ? 82  THR U CB   1 
ATOM   565  O OG1  . THR A  1 82  ? 123.652 122.513 92.566  1.00 40.35  ? 82  THR U OG1  1 
ATOM   566  C CG2  . THR A  1 82  ? 123.405 122.100 94.921  1.00 48.00  ? 82  THR U CG2  1 
ATOM   567  N N    . ARG A  1 83  ? 126.636 120.469 95.337  1.00 49.88  ? 83  ARG U N    1 
ATOM   568  C CA   . ARG A  1 83  ? 127.182 120.011 96.606  1.00 42.82  ? 83  ARG U CA   1 
ATOM   569  C C    . ARG A  1 83  ? 128.372 120.851 97.050  1.00 44.01  ? 83  ARG U C    1 
ATOM   570  O O    . ARG A  1 83  ? 128.718 120.839 98.235  1.00 52.86  ? 83  ARG U O    1 
ATOM   571  C CB   . ARG A  1 83  ? 127.582 118.543 96.491  1.00 46.15  ? 83  ARG U CB   1 
ATOM   572  C CG   . ARG A  1 83  ? 127.743 117.823 97.809  1.00 48.75  ? 83  ARG U CG   1 
ATOM   573  C CD   . ARG A  1 83  ? 127.392 116.360 97.631  1.00 52.47  ? 83  ARG U CD   1 
ATOM   574  N NE   . ARG A  1 83  ? 127.979 115.819 96.411  1.00 55.58  ? 83  ARG U NE   1 
ATOM   575  C CZ   . ARG A  1 83  ? 127.544 114.733 95.787  1.00 54.29  ? 83  ARG U CZ   1 
ATOM   576  N NH1  . ARG A  1 83  ? 126.506 114.047 96.237  1.00 50.19  ? 83  ARG U NH1  1 
ATOM   577  N NH2  . ARG A  1 83  ? 128.162 114.328 94.682  1.00 52.03  ? 83  ARG U NH2  1 
ATOM   578  N N    . ALA A  1 84  ? 129.001 121.579 96.130  1.00 41.89  ? 84  ALA U N    1 
ATOM   579  C CA   . ALA A  1 84  ? 130.139 122.432 96.439  1.00 37.35  ? 84  ALA U CA   1 
ATOM   580  C C    . ALA A  1 84  ? 129.759 123.891 96.642  1.00 40.13  ? 84  ALA U C    1 
ATOM   581  O O    . ALA A  1 84  ? 130.647 124.722 96.845  1.00 43.93  ? 84  ALA U O    1 
ATOM   582  C CB   . ALA A  1 84  ? 131.193 122.326 95.333  1.00 39.35  ? 84  ALA U CB   1 
ATOM   583  N N    . GLY A  1 85  ? 128.472 124.226 96.583  1.00 42.48  ? 85  GLY U N    1 
ATOM   584  C CA   . GLY A  1 85  ? 128.017 125.580 96.836  1.00 40.59  ? 85  GLY U CA   1 
ATOM   585  C C    . GLY A  1 85  ? 127.526 126.344 95.625  1.00 43.07  ? 85  GLY U C    1 
ATOM   586  O O    . GLY A  1 85  ? 127.258 127.545 95.747  1.00 51.03  ? 85  GLY U O    1 
ATOM   587  N N    . ILE A  1 86  ? 127.397 125.707 94.469  1.00 40.27  ? 86  ILE U N    1 
ATOM   588  C CA   . ILE A  1 86  ? 126.902 126.384 93.276  1.00 34.34  ? 86  ILE U CA   1 
ATOM   589  C C    . ILE A  1 86  ? 125.382 126.430 93.308  1.00 38.42  ? 86  ILE U C    1 
ATOM   590  O O    . ILE A  1 86  ? 124.724 125.483 93.755  1.00 43.56  ? 86  ILE U O    1 
ATOM   591  C CB   . ILE A  1 86  ? 127.408 125.681 92.005  1.00 38.97  ? 86  ILE U CB   1 
ATOM   592  C CG1  . ILE A  1 86  ? 128.909 125.901 91.835  1.00 38.82  ? 86  ILE U CG1  1 
ATOM   593  C CG2  . ILE A  1 86  ? 126.663 126.192 90.789  1.00 39.05  ? 86  ILE U CG2  1 
ATOM   594  C CD1  . ILE A  1 86  ? 129.273 127.327 91.510  1.00 39.65  ? 86  ILE U CD1  1 
ATOM   595  N N    . ARG A  1 87  ? 124.818 127.538 92.837  1.00 47.26  ? 87  ARG U N    1 
ATOM   596  C CA   . ARG A  1 87  ? 123.378 127.690 92.716  1.00 48.08  ? 87  ARG U CA   1 
ATOM   597  C C    . ARG A  1 87  ? 123.066 128.408 91.413  1.00 48.84  ? 87  ARG U C    1 
ATOM   598  O O    . ARG A  1 87  ? 123.916 129.092 90.838  1.00 52.63  ? 87  ARG U O    1 
ATOM   599  C CB   . ARG A  1 87  ? 122.779 128.466 93.895  1.00 46.28  ? 87  ARG U CB   1 
ATOM   600  C CG   . ARG A  1 87  ? 122.903 127.774 95.237  1.00 46.05  ? 87  ARG U CG   1 
ATOM   601  C CD   . ARG A  1 87  ? 122.199 126.434 95.238  1.00 47.86  ? 87  ARG U CD   1 
ATOM   602  N NE   . ARG A  1 87  ? 122.033 125.913 96.588  1.00 52.95  ? 87  ARG U NE   1 
ATOM   603  C CZ   . ARG A  1 87  ? 122.986 125.304 97.279  1.00 53.81  ? 87  ARG U CZ   1 
ATOM   604  N NH1  . ARG A  1 87  ? 124.198 125.131 96.779  1.00 47.38  ? 87  ARG U NH1  1 
ATOM   605  N NH2  . ARG A  1 87  ? 122.718 124.861 98.504  1.00 54.90  ? 87  ARG U NH2  1 
ATOM   606  N N    . VAL A  1 88  ? 121.829 128.240 90.945  1.00 55.37  ? 88  VAL U N    1 
ATOM   607  C CA   . VAL A  1 88  ? 121.405 128.933 89.732  1.00 56.18  ? 88  VAL U CA   1 
ATOM   608  C C    . VAL A  1 88  ? 121.441 130.441 89.945  1.00 57.51  ? 88  VAL U C    1 
ATOM   609  O O    . VAL A  1 88  ? 121.884 131.195 89.072  1.00 54.82  ? 88  VAL U O    1 
ATOM   610  C CB   . VAL A  1 88  ? 120.009 128.450 89.298  1.00 52.97  ? 88  VAL U CB   1 
ATOM   611  C CG1  . VAL A  1 88  ? 118.982 128.751 90.374  1.00 52.02  ? 88  VAL U CG1  1 
ATOM   612  C CG2  . VAL A  1 88  ? 119.616 129.093 87.980  1.00 51.54  ? 88  VAL U CG2  1 
ATOM   613  N N    . ASP A  1 89  ? 120.974 130.901 91.100  1.00 58.14  ? 89  ASP U N    1 
ATOM   614  C CA   . ASP A  1 89  ? 121.067 132.304 91.468  1.00 56.69  ? 89  ASP U CA   1 
ATOM   615  C C    . ASP A  1 89  ? 122.433 132.602 92.076  1.00 60.16  ? 89  ASP U C    1 
ATOM   616  O O    . ASP A  1 89  ? 123.169 131.702 92.486  1.00 64.96  ? 89  ASP U O    1 
ATOM   617  C CB   . ASP A  1 89  ? 119.964 132.683 92.456  1.00 57.13  ? 89  ASP U CB   1 
ATOM   618  C CG   . ASP A  1 89  ? 118.581 132.578 91.852  1.00 64.20  ? 89  ASP U CG   1 
ATOM   619  O OD1  . ASP A  1 89  ? 118.446 132.798 90.631  1.00 63.97  ? 89  ASP U OD1  1 
ATOM   620  O OD2  . ASP A  1 89  ? 117.626 132.277 92.598  1.00 66.61  ? 89  ASP U OD2  1 
ATOM   621  N N    . ASN A  1 90  ? 122.769 133.886 92.129  1.00 57.60  ? 90  ASN U N    1 
ATOM   622  C CA   . ASN A  1 90  ? 124.034 134.298 92.717  1.00 54.35  ? 90  ASN U CA   1 
ATOM   623  C C    . ASN A  1 90  ? 123.981 134.141 94.230  1.00 53.43  ? 90  ASN U C    1 
ATOM   624  O O    . ASN A  1 90  ? 123.021 134.570 94.875  1.00 57.20  ? 90  ASN U O    1 
ATOM   625  C CB   . ASN A  1 90  ? 124.345 135.744 92.346  1.00 58.23  ? 90  ASN U CB   1 
ATOM   626  C CG   . ASN A  1 90  ? 124.340 135.973 90.851  1.00 60.95  ? 90  ASN U CG   1 
ATOM   627  O OD1  . ASN A  1 90  ? 123.789 135.177 90.092  1.00 62.03  ? 90  ASN U OD1  1 
ATOM   628  N ND2  . ASN A  1 90  ? 124.954 137.066 90.416  1.00 58.04  ? 90  ASN U ND2  1 
ATOM   629  N N    . VAL A  1 91  ? 125.015 133.519 94.797  1.00 40.53  ? 91  VAL U N    1 
ATOM   630  C CA   . VAL A  1 91  ? 125.111 133.322 96.235  1.00 40.05  ? 91  VAL U CA   1 
ATOM   631  C C    . VAL A  1 91  ? 126.509 133.705 96.698  1.00 36.80  ? 91  VAL U C    1 
ATOM   632  O O    . VAL A  1 91  ? 127.471 133.695 95.930  1.00 37.95  ? 91  VAL U O    1 
ATOM   633  C CB   . VAL A  1 91  ? 124.785 131.873 96.647  1.00 38.35  ? 91  VAL U CB   1 
ATOM   634  C CG1  . VAL A  1 91  ? 123.331 131.562 96.366  1.00 40.14  ? 91  VAL U CG1  1 
ATOM   635  C CG2  . VAL A  1 91  ? 125.688 130.904 95.914  1.00 41.74  ? 91  VAL U CG2  1 
ATOM   636  N N    . ARG A  1 92  ? 126.606 134.042 97.980  1.00 35.00  ? 92  ARG U N    1 
ATOM   637  C CA   . ARG A  1 92  ? 127.880 134.432 98.556  1.00 30.75  ? 92  ARG U CA   1 
ATOM   638  C C    . ARG A  1 92  ? 128.844 133.249 98.542  1.00 38.89  ? 92  ARG U C    1 
ATOM   639  O O    . ARG A  1 92  ? 128.427 132.094 98.667  1.00 47.06  ? 92  ARG U O    1 
ATOM   640  C CB   . ARG A  1 92  ? 127.686 134.926 99.985  1.00 31.55  ? 92  ARG U CB   1 
ATOM   641  C CG   . ARG A  1 92  ? 127.105 133.874 100.907 1.00 34.04  ? 92  ARG U CG   1 
ATOM   642  C CD   . ARG A  1 92  ? 126.763 134.442 102.269 1.00 35.87  ? 92  ARG U CD   1 
ATOM   643  N NE   . ARG A  1 92  ? 127.939 134.939 102.970 1.00 40.18  ? 92  ARG U NE   1 
ATOM   644  C CZ   . ARG A  1 92  ? 127.937 135.344 104.232 1.00 36.22  ? 92  ARG U CZ   1 
ATOM   645  N NH1  . ARG A  1 92  ? 126.838 135.310 104.966 1.00 31.46  ? 92  ARG U NH1  1 
ATOM   646  N NH2  . ARG A  1 92  ? 129.066 135.794 104.770 1.00 36.48  ? 92  ARG U NH2  1 
ATOM   647  N N    . PRO A  1 93  ? 130.140 133.504 98.394  1.00 34.48  ? 93  PRO U N    1 
ATOM   648  C CA   . PRO A  1 93  ? 131.107 132.405 98.391  1.00 27.30  ? 93  PRO U CA   1 
ATOM   649  C C    . PRO A  1 93  ? 131.175 131.714 99.741  1.00 29.33  ? 93  PRO U C    1 
ATOM   650  O O    . PRO A  1 93  ? 130.936 132.315 100.791 1.00 40.19  ? 93  PRO U O    1 
ATOM   651  C CB   . PRO A  1 93  ? 132.431 133.100 98.059  1.00 26.21  ? 93  PRO U CB   1 
ATOM   652  C CG   . PRO A  1 93  ? 132.235 134.499 98.511  1.00 31.50  ? 93  PRO U CG   1 
ATOM   653  C CD   . PRO A  1 93  ? 130.794 134.814 98.248  1.00 34.44  ? 93  PRO U CD   1 
ATOM   654  N N    . ARG A  1 94  ? 131.505 130.428 99.703  1.00 31.27  ? 94  ARG U N    1 
ATOM   655  C CA   . ARG A  1 94  ? 131.736 129.654 100.911 1.00 32.39  ? 94  ARG U CA   1 
ATOM   656  C C    . ARG A  1 94  ? 133.222 129.631 101.246 1.00 41.18  ? 94  ARG U C    1 
ATOM   657  O O    . ARG A  1 94  ? 134.077 129.521 100.364 1.00 49.14  ? 94  ARG U O    1 
ATOM   658  C CB   . ARG A  1 94  ? 131.234 128.219 100.751 1.00 31.34  ? 94  ARG U CB   1 
ATOM   659  C CG   . ARG A  1 94  ? 129.736 128.046 100.865 1.00 32.07  ? 94  ARG U CG   1 
ATOM   660  C CD   . ARG A  1 94  ? 129.016 128.573 99.647  1.00 30.05  ? 94  ARG U CD   1 
ATOM   661  N NE   . ARG A  1 94  ? 127.578 128.367 99.753  1.00 32.44  ? 94  ARG U NE   1 
ATOM   662  C CZ   . ARG A  1 94  ? 126.745 129.214 100.339 1.00 35.53  ? 94  ARG U CZ   1 
ATOM   663  N NH1  . ARG A  1 94  ? 127.170 130.343 100.875 1.00 32.71  ? 94  ARG U NH1  1 
ATOM   664  N NH2  . ARG A  1 94  ? 125.450 128.919 100.389 1.00 35.89  ? 94  ARG U NH2  1 
ATOM   665  N N    . TRP A  1 95  ? 133.521 129.741 102.537 1.00 24.64  ? 95  TRP U N    1 
ATOM   666  C CA   . TRP A  1 95  ? 134.865 129.507 103.053 1.00 26.68  ? 95  TRP U CA   1 
ATOM   667  C C    . TRP A  1 95  ? 135.825 130.663 102.789 1.00 29.14  ? 95  TRP U C    1 
ATOM   668  O O    . TRP A  1 95  ? 137.037 130.451 102.750 1.00 40.02  ? 95  TRP U O    1 
ATOM   669  C CB   . TRP A  1 95  ? 135.470 128.223 102.476 1.00 17.07  ? 95  TRP U CB   1 
ATOM   670  C CG   . TRP A  1 95  ? 134.676 126.985 102.697 1.00 21.27  ? 95  TRP U CG   1 
ATOM   671  C CD1  . TRP A  1 95  ? 134.166 126.161 101.740 1.00 23.77  ? 95  TRP U CD1  1 
ATOM   672  C CD2  . TRP A  1 95  ? 134.311 126.414 103.954 1.00 27.78  ? 95  TRP U CD2  1 
ATOM   673  N NE1  . TRP A  1 95  ? 133.501 125.115 102.322 1.00 23.77  ? 95  TRP U NE1  1 
ATOM   674  C CE2  . TRP A  1 95  ? 133.575 125.248 103.683 1.00 27.66  ? 95  TRP U CE2  1 
ATOM   675  C CE3  . TRP A  1 95  ? 134.531 126.777 105.283 1.00 23.21  ? 95  TRP U CE3  1 
ATOM   676  C CZ2  . TRP A  1 95  ? 133.058 124.444 104.691 1.00 24.31  ? 95  TRP U CZ2  1 
ATOM   677  C CZ3  . TRP A  1 95  ? 134.018 125.978 106.280 1.00 20.77  ? 95  TRP U CZ3  1 
ATOM   678  C CH2  . TRP A  1 95  ? 133.291 124.825 105.981 1.00 21.30  ? 95  TRP U CH2  1 
ATOM   679  N N    . ASP A  1 96  ? 135.347 131.893 102.597 1.00 23.57  ? 96  ASP U N    1 
ATOM   680  C CA   . ASP A  1 96  ? 136.320 132.963 102.371 1.00 31.22  ? 96  ASP U CA   1 
ATOM   681  C C    . ASP A  1 96  ? 136.882 133.476 103.695 1.00 41.23  ? 96  ASP U C    1 
ATOM   682  O O    . ASP A  1 96  ? 138.033 133.192 104.043 1.00 51.45  ? 96  ASP U O    1 
ATOM   683  C CB   . ASP A  1 96  ? 135.677 134.096 101.566 1.00 35.77  ? 96  ASP U CB   1 
ATOM   684  C CG   . ASP A  1 96  ? 134.323 134.492 102.102 1.00 42.20  ? 96  ASP U CG   1 
ATOM   685  O OD1  . ASP A  1 96  ? 133.843 133.823 103.039 1.00 43.51  ? 96  ASP U OD1  1 
ATOM   686  O OD2  . ASP A  1 96  ? 133.740 135.470 101.593 1.00 42.58  ? 96  ASP U OD2  1 
ATOM   687  N N    . PHE A  1 97  ? 136.086 134.230 104.450 1.00 34.15  ? 97  PHE U N    1 
ATOM   688  C CA   . PHE A  1 97  ? 136.236 134.317 105.899 1.00 26.36  ? 97  PHE U CA   1 
ATOM   689  C C    . PHE A  1 97  ? 134.915 134.428 106.642 1.00 30.83  ? 97  PHE U C    1 
ATOM   690  O O    . PHE A  1 97  ? 134.859 134.050 107.816 1.00 34.71  ? 97  PHE U O    1 
ATOM   691  C CB   . PHE A  1 97  ? 137.125 135.496 106.304 1.00 26.31  ? 97  PHE U CB   1 
ATOM   692  C CG   . PHE A  1 97  ? 137.347 135.593 107.787 1.00 30.46  ? 97  PHE U CG   1 
ATOM   693  C CD1  . PHE A  1 97  ? 138.354 134.870 108.396 1.00 29.32  ? 97  PHE U CD1  1 
ATOM   694  C CD2  . PHE A  1 97  ? 136.536 136.390 108.575 1.00 30.26  ? 97  PHE U CD2  1 
ATOM   695  C CE1  . PHE A  1 97  ? 138.554 134.949 109.758 1.00 29.47  ? 97  PHE U CE1  1 
ATOM   696  C CE2  . PHE A  1 97  ? 136.733 136.470 109.936 1.00 25.88  ? 97  PHE U CE2  1 
ATOM   697  C CZ   . PHE A  1 97  ? 137.742 135.749 110.528 1.00 27.09  ? 97  PHE U CZ   1 
ATOM   698  N N    . THR A  1 98  ? 133.857 134.931 106.013 1.00 32.10  ? 98  THR U N    1 
ATOM   699  C CA   . THR A  1 98  ? 132.574 135.108 106.672 1.00 33.06  ? 98  THR U CA   1 
ATOM   700  C C    . THR A  1 98  ? 131.667 133.905 106.486 1.00 33.94  ? 98  THR U C    1 
ATOM   701  O O    . THR A  1 98  ? 130.861 133.601 107.373 1.00 39.59  ? 98  THR U O    1 
ATOM   702  C CB   . THR A  1 98  ? 131.881 136.364 106.143 1.00 31.65  ? 98  THR U CB   1 
ATOM   703  O OG1  . THR A  1 98  ? 131.501 136.158 104.780 1.00 38.44  ? 98  THR U OG1  1 
ATOM   704  C CG2  . THR A  1 98  ? 132.821 137.552 106.218 1.00 22.10  ? 98  THR U CG2  1 
ATOM   705  N N    . GLY A  1 99  ? 131.781 133.210 105.355 1.00 26.02  ? 99  GLY U N    1 
ATOM   706  C CA   . GLY A  1 99  ? 131.125 131.923 105.234 1.00 27.63  ? 99  GLY U CA   1 
ATOM   707  C C    . GLY A  1 99  ? 131.624 130.941 106.273 1.00 26.94  ? 99  GLY U C    1 
ATOM   708  O O    . GLY A  1 99  ? 130.846 130.174 106.842 1.00 30.46  ? 99  GLY U O    1 
ATOM   709  N N    . ALA A  1 100 ? 132.929 130.962 106.546 1.00 23.13  ? 100 ALA U N    1 
ATOM   710  C CA   . ALA A  1 100 ? 133.481 130.118 107.599 1.00 23.44  ? 100 ALA U CA   1 
ATOM   711  C C    . ALA A  1 100 ? 132.924 130.503 108.963 1.00 26.83  ? 100 ALA U C    1 
ATOM   712  O O    . ALA A  1 100 ? 132.627 129.634 109.789 1.00 29.76  ? 100 ALA U O    1 
ATOM   713  C CB   . ALA A  1 100 ? 135.005 130.205 107.595 1.00 23.62  ? 100 ALA U CB   1 
ATOM   714  N N    . PHE A  1 101 ? 132.791 131.805 109.225 1.00 18.71  ? 101 PHE U N    1 
ATOM   715  C CA   . PHE A  1 101 ? 132.224 132.247 110.495 1.00 20.81  ? 101 PHE U CA   1 
ATOM   716  C C    . PHE A  1 101 ? 130.780 131.784 110.640 1.00 26.53  ? 101 PHE U C    1 
ATOM   717  O O    . PHE A  1 101 ? 130.379 131.291 111.701 1.00 33.48  ? 101 PHE U O    1 
ATOM   718  C CB   . PHE A  1 101 ? 132.317 133.768 110.600 1.00 22.23  ? 101 PHE U CB   1 
ATOM   719  C CG   . PHE A  1 101 ? 132.010 134.302 111.966 1.00 31.49  ? 101 PHE U CG   1 
ATOM   720  C CD1  . PHE A  1 101 ? 133.010 134.443 112.907 1.00 23.16  ? 101 PHE U CD1  1 
ATOM   721  C CD2  . PHE A  1 101 ? 130.722 134.667 112.308 1.00 29.18  ? 101 PHE U CD2  1 
ATOM   722  C CE1  . PHE A  1 101 ? 132.732 134.934 114.163 1.00 23.67  ? 101 PHE U CE1  1 
ATOM   723  C CE2  . PHE A  1 101 ? 130.440 135.159 113.563 1.00 21.78  ? 101 PHE U CE2  1 
ATOM   724  C CZ   . PHE A  1 101 ? 131.446 135.292 114.491 1.00 25.59  ? 101 PHE U CZ   1 
ATOM   725  N N    . TYR A  1 102 ? 129.989 131.920 109.576 1.00 20.15  ? 102 TYR U N    1 
ATOM   726  C CA   . TYR A  1 102 ? 128.614 131.437 109.599 1.00 24.46  ? 102 TYR U CA   1 
ATOM   727  C C    . TYR A  1 102 ? 128.570 129.932 109.836 1.00 30.55  ? 102 TYR U C    1 
ATOM   728  O O    . TYR A  1 102 ? 127.742 129.436 110.611 1.00 29.35  ? 102 TYR U O    1 
ATOM   729  C CB   . TYR A  1 102 ? 127.931 131.802 108.280 1.00 21.52  ? 102 TYR U CB   1 
ATOM   730  C CG   . TYR A  1 102 ? 126.424 131.870 108.326 1.00 30.51  ? 102 TYR U CG   1 
ATOM   731  C CD1  . TYR A  1 102 ? 125.704 131.224 109.317 1.00 33.47  ? 102 TYR U CD1  1 
ATOM   732  C CD2  . TYR A  1 102 ? 125.721 132.582 107.368 1.00 24.89  ? 102 TYR U CD2  1 
ATOM   733  C CE1  . TYR A  1 102 ? 124.329 131.287 109.351 1.00 32.64  ? 102 TYR U CE1  1 
ATOM   734  C CE2  . TYR A  1 102 ? 124.348 132.650 107.396 1.00 26.44  ? 102 TYR U CE2  1 
ATOM   735  C CZ   . TYR A  1 102 ? 123.658 132.002 108.389 1.00 29.36  ? 102 TYR U CZ   1 
ATOM   736  O OH   . TYR A  1 102 ? 122.288 132.070 108.417 1.00 35.53  ? 102 TYR U OH   1 
ATOM   737  N N    . PHE A  1 103 ? 129.460 129.190 109.176 1.00 24.29  ? 103 PHE U N    1 
ATOM   738  C CA   . PHE A  1 103 ? 129.491 127.741 109.331 1.00 20.28  ? 103 PHE U CA   1 
ATOM   739  C C    . PHE A  1 103 ? 129.818 127.344 110.765 1.00 21.90  ? 103 PHE U C    1 
ATOM   740  O O    . PHE A  1 103 ? 129.164 126.472 111.345 1.00 28.27  ? 103 PHE U O    1 
ATOM   741  C CB   . PHE A  1 103 ? 130.505 127.146 108.355 1.00 20.48  ? 103 PHE U CB   1 
ATOM   742  C CG   . PHE A  1 103 ? 130.788 125.696 108.584 1.00 28.62  ? 103 PHE U CG   1 
ATOM   743  C CD1  . PHE A  1 103 ? 129.896 124.728 108.168 1.00 20.23  ? 103 PHE U CD1  1 
ATOM   744  C CD2  . PHE A  1 103 ? 131.954 125.296 109.206 1.00 26.97  ? 103 PHE U CD2  1 
ATOM   745  C CE1  . PHE A  1 103 ? 130.158 123.396 108.374 1.00 20.76  ? 103 PHE U CE1  1 
ATOM   746  C CE2  . PHE A  1 103 ? 132.219 123.964 109.415 1.00 24.37  ? 103 PHE U CE2  1 
ATOM   747  C CZ   . PHE A  1 103 ? 131.321 123.013 108.999 1.00 23.09  ? 103 PHE U CZ   1 
ATOM   748  N N    . VAL A  1 104 ? 130.830 127.977 111.357 1.00 23.41  ? 104 VAL U N    1 
ATOM   749  C CA   . VAL A  1 104 ? 131.195 127.637 112.729 1.00 24.13  ? 104 VAL U CA   1 
ATOM   750  C C    . VAL A  1 104 ? 130.072 128.010 113.686 1.00 21.55  ? 104 VAL U C    1 
ATOM   751  O O    . VAL A  1 104 ? 129.797 127.290 114.654 1.00 23.96  ? 104 VAL U O    1 
ATOM   752  C CB   . VAL A  1 104 ? 132.524 128.303 113.118 1.00 22.84  ? 104 VAL U CB   1 
ATOM   753  C CG1  . VAL A  1 104 ? 133.648 127.774 112.255 1.00 18.28  ? 104 VAL U CG1  1 
ATOM   754  C CG2  . VAL A  1 104 ? 132.419 129.804 112.992 1.00 18.37  ? 104 VAL U CG2  1 
ATOM   755  N N    . GLY A  1 105 ? 129.403 129.137 113.436 1.00 31.69  ? 105 GLY U N    1 
ATOM   756  C CA   . GLY A  1 105 ? 128.263 129.497 114.261 1.00 20.64  ? 105 GLY U CA   1 
ATOM   757  C C    . GLY A  1 105 ? 127.157 128.463 114.199 1.00 21.40  ? 105 GLY U C    1 
ATOM   758  O O    . GLY A  1 105 ? 126.565 128.110 115.220 1.00 25.60  ? 105 GLY U O    1 
ATOM   759  N N    . THR A  1 106 ? 126.862 127.963 112.998 1.00 29.37  ? 106 THR U N    1 
ATOM   760  C CA   . THR A  1 106 ? 125.845 126.925 112.869 1.00 23.58  ? 106 THR U CA   1 
ATOM   761  C C    . THR A  1 106 ? 126.312 125.586 113.424 1.00 27.21  ? 106 THR U C    1 
ATOM   762  O O    . THR A  1 106 ? 125.476 124.729 113.725 1.00 32.38  ? 106 THR U O    1 
ATOM   763  C CB   . THR A  1 106 ? 125.432 126.752 111.408 1.00 25.07  ? 106 THR U CB   1 
ATOM   764  O OG1  . THR A  1 106 ? 126.535 126.231 110.658 1.00 28.40  ? 106 THR U OG1  1 
ATOM   765  C CG2  . THR A  1 106 ? 125.008 128.081 110.818 1.00 26.50  ? 106 THR U CG2  1 
ATOM   766  N N    . VAL A  1 107 ? 127.621 125.381 113.550 1.00 25.97  ? 107 VAL U N    1 
ATOM   767  C CA   . VAL A  1 107 ? 128.127 124.115 114.070 1.00 15.18  ? 107 VAL U CA   1 
ATOM   768  C C    . VAL A  1 107 ? 128.076 124.089 115.592 1.00 17.40  ? 107 VAL U C    1 
ATOM   769  O O    . VAL A  1 107 ? 127.566 123.139 116.191 1.00 25.07  ? 107 VAL U O    1 
ATOM   770  C CB   . VAL A  1 107 ? 129.552 123.854 113.553 1.00 18.94  ? 107 VAL U CB   1 
ATOM   771  C CG1  . VAL A  1 107 ? 130.200 122.735 114.342 1.00 21.84  ? 107 VAL U CG1  1 
ATOM   772  C CG2  . VAL A  1 107 ? 129.522 123.512 112.079 1.00 18.54  ? 107 VAL U CG2  1 
ATOM   773  N N    . VAL A  1 108 ? 128.603 125.129 116.243 1.00 24.86  ? 108 VAL U N    1 
ATOM   774  C CA   . VAL A  1 108 ? 128.675 125.111 117.702 1.00 21.42  ? 108 VAL U CA   1 
ATOM   775  C C    . VAL A  1 108 ? 127.285 125.092 118.319 1.00 26.22  ? 108 VAL U C    1 
ATOM   776  O O    . VAL A  1 108 ? 127.069 124.465 119.361 1.00 30.03  ? 108 VAL U O    1 
ATOM   777  C CB   . VAL A  1 108 ? 129.502 126.300 118.223 1.00 17.79  ? 108 VAL U CB   1 
ATOM   778  C CG1  . VAL A  1 108 ? 130.931 126.204 117.726 1.00 18.85  ? 108 VAL U CG1  1 
ATOM   779  C CG2  . VAL A  1 108 ? 128.869 127.608 117.804 1.00 18.11  ? 108 VAL U CG2  1 
ATOM   780  N N    . SER A  1 109 ? 126.324 125.772 117.701 1.00 29.84  ? 109 SER U N    1 
ATOM   781  C CA   . SER A  1 109 ? 124.959 125.787 118.205 1.00 19.81  ? 109 SER U CA   1 
ATOM   782  C C    . SER A  1 109 ? 124.172 124.542 117.821 1.00 25.93  ? 109 SER U C    1 
ATOM   783  O O    . SER A  1 109 ? 123.020 124.403 118.243 1.00 26.90  ? 109 SER U O    1 
ATOM   784  C CB   . SER A  1 109 ? 124.227 127.030 117.700 1.00 23.94  ? 109 SER U CB   1 
ATOM   785  O OG   . SER A  1 109 ? 124.184 127.049 116.287 1.00 23.82  ? 109 SER U OG   1 
ATOM   786  N N    . THR A  1 110 ? 124.746 123.640 117.049 1.00 29.78  ? 110 THR U N    1 
ATOM   787  C CA   . THR A  1 110 ? 124.089 122.372 116.640 1.00 26.17  ? 110 THR U CA   1 
ATOM   788  C C    . THR A  1 110 ? 122.917 122.643 115.699 1.00 24.62  ? 110 THR U C    1 
ATOM   789  O O    . THR A  1 110 ? 122.105 121.740 115.544 1.00 33.57  ? 110 THR U O    1 
ATOM   790  C CB   . THR A  1 110 ? 123.711 121.496 117.836 1.00 29.82  ? 110 THR U CB   1 
ATOM   791  O OG1  . THR A  1 110 ? 122.812 122.181 118.705 1.00 35.96  ? 110 THR U OG1  1 
ATOM   792  C CG2  . THR A  1 110 ? 124.916 121.040 118.627 1.00 27.26  ? 110 THR U CG2  1 
ATOM   793  N N    . ILE A  1 111 ? 122.902 123.772 115.007 1.00 14.87  ? 111 ILE U N    1 
ATOM   794  C CA   . ILE A  1 111 ? 121.832 124.033 114.051 1.00 19.30  ? 111 ILE U CA   1 
ATOM   795  C C    . ILE A  1 111 ? 122.057 123.240 112.774 1.00 28.91  ? 111 ILE U C    1 
ATOM   796  O O    . ILE A  1 111 ? 121.171 122.511 112.314 1.00 35.69  ? 111 ILE U O    1 
ATOM   797  C CB   . ILE A  1 111 ? 121.719 125.541 113.765 1.00 27.41  ? 111 ILE U CB   1 
ATOM   798  C CG1  . ILE A  1 111 ? 121.380 126.303 115.043 1.00 28.99  ? 111 ILE U CG1  1 
ATOM   799  C CG2  . ILE A  1 111 ? 120.666 125.798 112.711 1.00 17.79  ? 111 ILE U CG2  1 
ATOM   800  C CD1  . ILE A  1 111 ? 121.197 127.782 114.832 1.00 25.36  ? 111 ILE U CD1  1 
ATOM   801  N N    . GLY A  1 112 ? 123.245 123.358 112.190 1.00 25.14  ? 112 GLY U N    1 
ATOM   802  C CA   . GLY A  1 112 ? 123.591 122.587 111.015 1.00 17.29  ? 112 GLY U CA   1 
ATOM   803  C C    . GLY A  1 112 ? 122.667 122.782 109.834 1.00 23.62  ? 112 GLY U C    1 
ATOM   804  O O    . GLY A  1 112 ? 121.976 121.848 109.419 1.00 30.88  ? 112 GLY U O    1 
ATOM   805  N N    . PHE A  1 113 ? 122.600 124.003 109.313 1.00 27.26  ? 113 PHE U N    1 
ATOM   806  C CA   . PHE A  1 113 ? 121.796 124.249 108.121 1.00 21.69  ? 113 PHE U CA   1 
ATOM   807  C C    . PHE A  1 113 ? 122.175 123.343 106.960 1.00 29.65  ? 113 PHE U C    1 
ATOM   808  O O    . PHE A  1 113 ? 121.304 122.845 106.239 1.00 35.52  ? 113 PHE U O    1 
ATOM   809  C CB   . PHE A  1 113 ? 121.895 125.716 107.709 1.00 20.93  ? 113 PHE U CB   1 
ATOM   810  C CG   . PHE A  1 113 ? 121.060 126.638 108.545 1.00 31.55  ? 113 PHE U CG   1 
ATOM   811  C CD1  . PHE A  1 113 ? 119.800 126.260 108.964 1.00 37.21  ? 113 PHE U CD1  1 
ATOM   812  C CD2  . PHE A  1 113 ? 121.537 127.879 108.915 1.00 30.69  ? 113 PHE U CD2  1 
ATOM   813  C CE1  . PHE A  1 113 ? 119.031 127.106 109.731 1.00 32.78  ? 113 PHE U CE1  1 
ATOM   814  C CE2  . PHE A  1 113 ? 120.773 128.727 109.683 1.00 27.63  ? 113 PHE U CE2  1 
ATOM   815  C CZ   . PHE A  1 113 ? 119.518 128.340 110.092 1.00 28.67  ? 113 PHE U CZ   1 
ATOM   816  N N    . GLY A  1 114 ? 123.469 123.114 106.764 1.00 28.40  ? 114 GLY U N    1 
ATOM   817  C CA   . GLY A  1 114 ? 123.940 122.269 105.692 1.00 30.73  ? 114 GLY U CA   1 
ATOM   818  C C    . GLY A  1 114 ? 124.248 122.979 104.395 1.00 31.47  ? 114 GLY U C    1 
ATOM   819  O O    . GLY A  1 114 ? 124.708 122.328 103.449 1.00 36.47  ? 114 GLY U O    1 
ATOM   820  N N    . MET A  1 115 ? 124.006 124.288 104.310 1.00 29.30  ? 115 MET U N    1 
ATOM   821  C CA   . MET A  1 115 ? 124.364 125.021 103.104 1.00 28.12  ? 115 MET U CA   1 
ATOM   822  C C    . MET A  1 115 ? 125.869 125.056 102.885 1.00 32.04  ? 115 MET U C    1 
ATOM   823  O O    . MET A  1 115 ? 126.314 125.269 101.753 1.00 35.49  ? 115 MET U O    1 
ATOM   824  C CB   . MET A  1 115 ? 123.813 126.445 103.165 1.00 27.42  ? 115 MET U CB   1 
ATOM   825  C CG   . MET A  1 115 ? 124.573 127.371 104.097 1.00 31.99  ? 115 MET U CG   1 
ATOM   826  S SD   . MET A  1 115 ? 124.498 126.879 105.826 1.00 47.55  ? 115 MET U SD   1 
ATOM   827  C CE   . MET A  1 115 ? 125.502 128.156 106.577 1.00 24.77  ? 115 MET U CE   1 
ATOM   828  N N    . THR A  1 116 ? 126.654 124.850 103.939 1.00 30.17  ? 116 THR U N    1 
ATOM   829  C CA   . THR A  1 116 ? 128.108 124.802 103.846 1.00 23.56  ? 116 THR U CA   1 
ATOM   830  C C    . THR A  1 116 ? 128.593 123.615 104.658 1.00 27.59  ? 116 THR U C    1 
ATOM   831  O O    . THR A  1 116 ? 128.359 123.557 105.868 1.00 35.87  ? 116 THR U O    1 
ATOM   832  C CB   . THR A  1 116 ? 128.741 126.096 104.361 1.00 21.09  ? 116 THR U CB   1 
ATOM   833  O OG1  . THR A  1 116 ? 128.296 127.199 103.565 1.00 33.26  ? 116 THR U OG1  1 
ATOM   834  C CG2  . THR A  1 116 ? 130.249 126.012 104.292 1.00 18.20  ? 116 THR U CG2  1 
ATOM   835  N N    . THR A  1 117 ? 129.261 122.672 104.002 1.00 31.30  ? 117 THR U N    1 
ATOM   836  C CA   . THR A  1 117 ? 129.758 121.482 104.669 1.00 27.19  ? 117 THR U CA   1 
ATOM   837  C C    . THR A  1 117 ? 131.185 121.192 104.235 1.00 30.12  ? 117 THR U C    1 
ATOM   838  O O    . THR A  1 117 ? 131.570 121.504 103.103 1.00 28.41  ? 117 THR U O    1 
ATOM   839  C CB   . THR A  1 117 ? 128.879 120.264 104.362 1.00 26.57  ? 117 THR U CB   1 
ATOM   840  O OG1  . THR A  1 117 ? 128.880 120.021 102.951 1.00 40.61  ? 117 THR U OG1  1 
ATOM   841  C CG2  . THR A  1 117 ? 127.455 120.509 104.820 1.00 21.60  ? 117 THR U CG2  1 
ATOM   842  N N    . PRO A  1 118 ? 131.992 120.597 105.111 1.00 30.04  ? 118 PRO U N    1 
ATOM   843  C CA   . PRO A  1 118 ? 133.358 120.236 104.723 1.00 27.21  ? 118 PRO U CA   1 
ATOM   844  C C    . PRO A  1 118 ? 133.351 119.219 103.594 1.00 28.87  ? 118 PRO U C    1 
ATOM   845  O O    . PRO A  1 118 ? 132.464 118.370 103.500 1.00 35.99  ? 118 PRO U O    1 
ATOM   846  C CB   . PRO A  1 118 ? 133.948 119.643 106.007 1.00 24.75  ? 118 PRO U CB   1 
ATOM   847  C CG   . PRO A  1 118 ? 133.081 120.157 107.102 1.00 28.98  ? 118 PRO U CG   1 
ATOM   848  C CD   . PRO A  1 118 ? 131.714 120.267 106.516 1.00 29.64  ? 118 PRO U CD   1 
ATOM   849  N N    . ALA A  1 119 ? 134.359 119.312 102.730 1.00 24.35  ? 119 ALA U N    1 
ATOM   850  C CA   . ALA A  1 119 ? 134.439 118.444 101.567 1.00 25.87  ? 119 ALA U CA   1 
ATOM   851  C C    . ALA A  1 119 ? 135.792 117.774 101.391 1.00 33.19  ? 119 ALA U C    1 
ATOM   852  O O    . ALA A  1 119 ? 135.984 117.064 100.398 1.00 41.40  ? 119 ALA U O    1 
ATOM   853  C CB   . ALA A  1 119 ? 134.102 119.229 100.292 1.00 30.10  ? 119 ALA U CB   1 
ATOM   854  N N    . THR A  1 120 ? 136.729 117.966 102.313 1.00 32.22  ? 120 THR U N    1 
ATOM   855  C CA   . THR A  1 120 ? 138.064 117.408 102.191 1.00 30.23  ? 120 THR U CA   1 
ATOM   856  C C    . THR A  1 120 ? 138.453 116.711 103.484 1.00 33.79  ? 120 THR U C    1 
ATOM   857  O O    . THR A  1 120 ? 137.973 117.060 104.565 1.00 40.07  ? 120 THR U O    1 
ATOM   858  C CB   . THR A  1 120 ? 139.101 118.489 101.869 1.00 30.58  ? 120 THR U CB   1 
ATOM   859  O OG1  . THR A  1 120 ? 139.153 119.434 102.943 1.00 26.06  ? 120 THR U OG1  1 
ATOM   860  C CG2  . THR A  1 120 ? 138.731 119.214 100.591 1.00 29.03  ? 120 THR U CG2  1 
ATOM   861  N N    . VAL A  1 121 ? 139.328 115.714 103.363 1.00 37.91  ? 121 VAL U N    1 
ATOM   862  C CA   . VAL A  1 121 ? 139.906 115.091 104.545 1.00 32.37  ? 121 VAL U CA   1 
ATOM   863  C C    . VAL A  1 121 ? 140.825 116.093 105.224 1.00 39.22  ? 121 VAL U C    1 
ATOM   864  O O    . VAL A  1 121 ? 141.712 116.680 104.590 1.00 42.33  ? 121 VAL U O    1 
ATOM   865  C CB   . VAL A  1 121 ? 140.657 113.807 104.169 1.00 33.60  ? 121 VAL U CB   1 
ATOM   866  C CG1  . VAL A  1 121 ? 141.279 113.184 105.403 1.00 32.03  ? 121 VAL U CG1  1 
ATOM   867  C CG2  . VAL A  1 121 ? 139.720 112.829 103.491 1.00 37.47  ? 121 VAL U CG2  1 
ATOM   868  N N    . GLY A  1 122 ? 140.621 116.292 106.520 1.00 30.56  ? 122 GLY U N    1 
ATOM   869  C CA   . GLY A  1 122 ? 141.292 117.358 107.228 1.00 25.90  ? 122 GLY U CA   1 
ATOM   870  C C    . GLY A  1 122 ? 140.280 118.398 107.649 1.00 31.90  ? 122 GLY U C    1 
ATOM   871  O O    . GLY A  1 122 ? 140.332 118.920 108.765 1.00 43.82  ? 122 GLY U O    1 
ATOM   872  N N    . GLY A  1 123 ? 139.345 118.700 106.753 1.00 23.97  ? 123 GLY U N    1 
ATOM   873  C CA   . GLY A  1 123 ? 138.202 119.510 107.115 1.00 22.86  ? 123 GLY U CA   1 
ATOM   874  C C    . GLY A  1 123 ? 137.107 118.756 107.825 1.00 28.22  ? 123 GLY U C    1 
ATOM   875  O O    . GLY A  1 123 ? 136.180 119.379 108.350 1.00 32.49  ? 123 GLY U O    1 
ATOM   876  N N    . LYS A  1 124 ? 137.192 117.428 107.851 1.00 32.30  ? 124 LYS U N    1 
ATOM   877  C CA   . LYS A  1 124 ? 136.246 116.584 108.567 1.00 27.53  ? 124 LYS U CA   1 
ATOM   878  C C    . LYS A  1 124 ? 136.767 116.138 109.925 1.00 31.78  ? 124 LYS U C    1 
ATOM   879  O O    . LYS A  1 124 ? 135.998 116.074 110.886 1.00 34.08  ? 124 LYS U O    1 
ATOM   880  C CB   . LYS A  1 124 ? 135.893 115.356 107.724 1.00 26.83  ? 124 LYS U CB   1 
ATOM   881  C CG   . LYS A  1 124 ? 135.231 115.695 106.402 1.00 24.30  ? 124 LYS U CG   1 
ATOM   882  C CD   . LYS A  1 124 ? 134.831 114.444 105.642 1.00 21.48  ? 124 LYS U CD   1 
ATOM   883  C CE   . LYS A  1 124 ? 134.094 114.793 104.364 1.00 25.22  ? 124 LYS U CE   1 
ATOM   884  N NZ   . LYS A  1 124 ? 133.703 113.580 103.600 1.00 30.22  ? 124 LYS U NZ   1 
ATOM   885  N N    . ILE A  1 125 ? 138.060 115.824 110.029 1.00 25.97  ? 125 ILE U N    1 
ATOM   886  C CA   . ILE A  1 125 ? 138.651 115.526 111.331 1.00 25.92  ? 125 ILE U CA   1 
ATOM   887  C C    . ILE A  1 125 ? 138.584 116.752 112.229 1.00 31.30  ? 125 ILE U C    1 
ATOM   888  O O    . ILE A  1 125 ? 138.121 116.692 113.379 1.00 33.77  ? 125 ILE U O    1 
ATOM   889  C CB   . ILE A  1 125 ? 140.101 115.042 111.156 1.00 23.43  ? 125 ILE U CB   1 
ATOM   890  C CG1  . ILE A  1 125 ? 140.183 113.987 110.056 1.00 19.28  ? 125 ILE U CG1  1 
ATOM   891  C CG2  . ILE A  1 125 ? 140.637 114.495 112.461 1.00 31.79  ? 125 ILE U CG2  1 
ATOM   892  C CD1  . ILE A  1 125 ? 141.594 113.593 109.705 1.00 22.18  ? 125 ILE U CD1  1 
ATOM   893  N N    . PHE A  1 126 ? 139.041 117.892 111.708 1.00 24.97  ? 126 PHE U N    1 
ATOM   894  C CA   . PHE A  1 126 ? 138.984 119.119 112.483 1.00 26.21  ? 126 PHE U CA   1 
ATOM   895  C C    . PHE A  1 126 ? 137.553 119.473 112.838 1.00 25.12  ? 126 PHE U C    1 
ATOM   896  O O    . PHE A  1 126 ? 137.305 120.014 113.915 1.00 31.02  ? 126 PHE U O    1 
ATOM   897  C CB   . PHE A  1 126 ? 139.641 120.267 111.723 1.00 23.24  ? 126 PHE U CB   1 
ATOM   898  C CG   . PHE A  1 126 ? 139.703 121.543 112.506 1.00 27.70  ? 126 PHE U CG   1 
ATOM   899  C CD1  . PHE A  1 126 ? 140.591 121.681 113.554 1.00 25.86  ? 126 PHE U CD1  1 
ATOM   900  C CD2  . PHE A  1 126 ? 138.870 122.601 112.199 1.00 27.93  ? 126 PHE U CD2  1 
ATOM   901  C CE1  . PHE A  1 126 ? 140.649 122.848 114.280 1.00 25.38  ? 126 PHE U CE1  1 
ATOM   902  C CE2  . PHE A  1 126 ? 138.925 123.771 112.922 1.00 23.71  ? 126 PHE U CE2  1 
ATOM   903  C CZ   . PHE A  1 126 ? 139.815 123.895 113.963 1.00 29.01  ? 126 PHE U CZ   1 
ATOM   904  N N    . LEU A  1 127 ? 136.599 119.177 111.956 1.00 17.26  ? 127 LEU U N    1 
ATOM   905  C CA   . LEU A  1 127 ? 135.202 119.406 112.302 1.00 22.32  ? 127 LEU U CA   1 
ATOM   906  C C    . LEU A  1 127 ? 134.802 118.579 113.514 1.00 27.70  ? 127 LEU U C    1 
ATOM   907  O O    . LEU A  1 127 ? 134.128 119.078 114.422 1.00 32.59  ? 127 LEU U O    1 
ATOM   908  C CB   . LEU A  1 127 ? 134.301 119.086 111.111 1.00 24.52  ? 127 LEU U CB   1 
ATOM   909  C CG   . LEU A  1 127 ? 132.792 119.241 111.311 1.00 23.12  ? 127 LEU U CG   1 
ATOM   910  C CD1  . LEU A  1 127 ? 132.188 118.000 111.941 1.00 22.65  ? 127 LEU U CD1  1 
ATOM   911  C CD2  . LEU A  1 127 ? 132.501 120.458 112.162 1.00 24.77  ? 127 LEU U CD2  1 
ATOM   912  N N    . ILE A  1 128 ? 135.223 117.314 113.554 1.00 28.12  ? 128 ILE U N    1 
ATOM   913  C CA   . ILE A  1 128 ? 134.876 116.451 114.678 1.00 27.24  ? 128 ILE U CA   1 
ATOM   914  C C    . ILE A  1 128 ? 135.436 117.020 115.974 1.00 28.67  ? 128 ILE U C    1 
ATOM   915  O O    . ILE A  1 128 ? 134.712 117.190 116.962 1.00 27.72  ? 128 ILE U O    1 
ATOM   916  C CB   . ILE A  1 128 ? 135.380 115.019 114.432 1.00 25.00  ? 128 ILE U CB   1 
ATOM   917  C CG1  . ILE A  1 128 ? 134.588 114.360 113.302 1.00 25.09  ? 128 ILE U CG1  1 
ATOM   918  C CG2  . ILE A  1 128 ? 135.285 114.199 115.701 1.00 23.74  ? 128 ILE U CG2  1 
ATOM   919  C CD1  . ILE A  1 128 ? 135.026 112.950 112.997 1.00 20.82  ? 128 ILE U CD1  1 
ATOM   920  N N    . PHE A  1 129 ? 136.732 117.339 115.986 1.00 29.90  ? 129 PHE U N    1 
ATOM   921  C CA   . PHE A  1 129 ? 137.331 117.844 117.221 1.00 25.51  ? 129 PHE U CA   1 
ATOM   922  C C    . PHE A  1 129 ? 136.743 119.195 117.617 1.00 27.53  ? 129 PHE U C    1 
ATOM   923  O O    . PHE A  1 129 ? 136.469 119.441 118.801 1.00 30.56  ? 129 PHE U O    1 
ATOM   924  C CB   . PHE A  1 129 ? 138.846 117.934 117.068 1.00 24.33  ? 129 PHE U CB   1 
ATOM   925  C CG   . PHE A  1 129 ? 139.524 116.600 117.050 1.00 28.40  ? 129 PHE U CG   1 
ATOM   926  C CD1  . PHE A  1 129 ? 139.867 115.970 118.231 1.00 33.80  ? 129 PHE U CD1  1 
ATOM   927  C CD2  . PHE A  1 129 ? 139.808 115.969 115.855 1.00 31.13  ? 129 PHE U CD2  1 
ATOM   928  C CE1  . PHE A  1 129 ? 140.484 114.737 118.220 1.00 34.55  ? 129 PHE U CE1  1 
ATOM   929  C CE2  . PHE A  1 129 ? 140.427 114.737 115.838 1.00 34.27  ? 129 PHE U CE2  1 
ATOM   930  C CZ   . PHE A  1 129 ? 140.765 114.121 117.021 1.00 34.70  ? 129 PHE U CZ   1 
ATOM   931  N N    . TYR A  1 130 ? 136.536 120.077 116.641 1.00 25.83  ? 130 TYR U N    1 
ATOM   932  C CA   . TYR A  1 130 ? 135.988 121.398 116.914 1.00 24.76  ? 130 TYR U CA   1 
ATOM   933  C C    . TYR A  1 130 ? 134.605 121.294 117.537 1.00 27.20  ? 130 TYR U C    1 
ATOM   934  O O    . TYR A  1 130 ? 134.324 121.931 118.555 1.00 28.21  ? 130 TYR U O    1 
ATOM   935  C CB   . TYR A  1 130 ? 135.945 122.197 115.612 1.00 16.82  ? 130 TYR U CB   1 
ATOM   936  C CG   . TYR A  1 130 ? 135.655 123.665 115.771 1.00 24.13  ? 130 TYR U CG   1 
ATOM   937  C CD1  . TYR A  1 130 ? 136.678 124.571 115.994 1.00 25.00  ? 130 TYR U CD1  1 
ATOM   938  C CD2  . TYR A  1 130 ? 134.361 124.149 115.675 1.00 23.41  ? 130 TYR U CD2  1 
ATOM   939  C CE1  . TYR A  1 130 ? 136.419 125.912 116.129 1.00 19.82  ? 130 TYR U CE1  1 
ATOM   940  C CE2  . TYR A  1 130 ? 134.095 125.489 115.811 1.00 24.53  ? 130 TYR U CE2  1 
ATOM   941  C CZ   . TYR A  1 130 ? 135.128 126.366 116.039 1.00 22.75  ? 130 TYR U CZ   1 
ATOM   942  O OH   . TYR A  1 130 ? 134.867 127.705 116.175 1.00 31.96  ? 130 TYR U OH   1 
ATOM   943  N N    . GLY A  1 131 ? 133.726 120.487 116.942 1.00 22.88  ? 131 GLY U N    1 
ATOM   944  C CA   . GLY A  1 131 ? 132.405 120.311 117.518 1.00 19.75  ? 131 GLY U CA   1 
ATOM   945  C C    . GLY A  1 131 ? 132.460 119.691 118.899 1.00 21.49  ? 131 GLY U C    1 
ATOM   946  O O    . GLY A  1 131 ? 131.766 120.137 119.818 1.00 26.60  ? 131 GLY U O    1 
ATOM   947  N N    . LEU A  1 132 ? 133.310 118.676 119.070 1.00 26.51  ? 132 LEU U N    1 
ATOM   948  C CA   . LEU A  1 132 ? 133.410 117.994 120.354 1.00 26.04  ? 132 LEU U CA   1 
ATOM   949  C C    . LEU A  1 132 ? 133.808 118.957 121.463 1.00 23.60  ? 132 LEU U C    1 
ATOM   950  O O    . LEU A  1 132 ? 133.298 118.867 122.584 1.00 29.30  ? 132 LEU U O    1 
ATOM   951  C CB   . LEU A  1 132 ? 134.415 116.848 120.252 1.00 25.86  ? 132 LEU U CB   1 
ATOM   952  C CG   . LEU A  1 132 ? 134.594 115.963 121.481 1.00 29.52  ? 132 LEU U CG   1 
ATOM   953  C CD1  . LEU A  1 132 ? 133.304 115.237 121.799 1.00 29.89  ? 132 LEU U CD1  1 
ATOM   954  C CD2  . LEU A  1 132 ? 135.724 114.979 121.251 1.00 30.54  ? 132 LEU U CD2  1 
ATOM   955  N N    . VAL A  1 133 ? 134.723 119.886 121.173 1.00 30.06  ? 133 VAL U N    1 
ATOM   956  C CA   . VAL A  1 133 ? 135.149 120.839 122.197 1.00 27.39  ? 133 VAL U CA   1 
ATOM   957  C C    . VAL A  1 133 ? 134.273 122.085 122.266 1.00 29.19  ? 133 VAL U C    1 
ATOM   958  O O    . VAL A  1 133 ? 134.359 122.831 123.252 1.00 25.34  ? 133 VAL U O    1 
ATOM   959  C CB   . VAL A  1 133 ? 136.614 121.265 121.986 1.00 27.89  ? 133 VAL U CB   1 
ATOM   960  C CG1  . VAL A  1 133 ? 137.061 122.189 123.102 1.00 21.06  ? 133 VAL U CG1  1 
ATOM   961  C CG2  . VAL A  1 133 ? 137.510 120.045 121.916 1.00 26.65  ? 133 VAL U CG2  1 
ATOM   962  N N    . GLY A  1 134 ? 133.430 122.333 121.266 1.00 28.23  ? 134 GLY U N    1 
ATOM   963  C CA   . GLY A  1 134 ? 132.666 123.564 121.239 1.00 16.94  ? 134 GLY U CA   1 
ATOM   964  C C    . GLY A  1 134 ? 131.213 123.469 121.653 1.00 21.53  ? 134 GLY U C    1 
ATOM   965  O O    . GLY A  1 134 ? 130.686 124.411 122.249 1.00 24.13  ? 134 GLY U O    1 
ATOM   966  N N    . CYS A  1 135 ? 130.542 122.361 121.339 1.00 25.79  ? 135 CYS U N    1 
ATOM   967  C CA   . CYS A  1 135 ? 129.130 122.243 121.704 1.00 22.99  ? 135 CYS U CA   1 
ATOM   968  C C    . CYS A  1 135 ? 128.909 122.318 123.210 1.00 30.57  ? 135 CYS U C    1 
ATOM   969  O O    . CYS A  1 135 ? 127.997 123.046 123.648 1.00 37.05  ? 135 CYS U O    1 
ATOM   970  C CB   . CYS A  1 135 ? 128.557 120.952 121.117 1.00 29.67  ? 135 CYS U CB   1 
ATOM   971  S SG   . CYS A  1 135 ? 128.591 120.881 119.313 1.00 33.91  ? 135 CYS U SG   1 
ATOM   972  N N    . PRO A  1 136 ? 129.673 121.610 124.045 1.00 26.56  ? 136 PRO U N    1 
ATOM   973  C CA   . PRO A  1 136 ? 129.476 121.745 125.497 1.00 17.63  ? 136 PRO U CA   1 
ATOM   974  C C    . PRO A  1 136 ? 129.619 123.173 125.989 1.00 23.78  ? 136 PRO U C    1 
ATOM   975  O O    . PRO A  1 136 ? 128.906 123.581 126.914 1.00 33.79  ? 136 PRO U O    1 
ATOM   976  C CB   . PRO A  1 136 ? 130.564 120.834 126.075 1.00 24.83  ? 136 PRO U CB   1 
ATOM   977  C CG   . PRO A  1 136 ? 130.834 119.846 125.006 1.00 20.88  ? 136 PRO U CG   1 
ATOM   978  C CD   . PRO A  1 136 ? 130.673 120.582 123.717 1.00 16.84  ? 136 PRO U CD   1 
ATOM   979  N N    . SER A  1 137 ? 130.527 123.949 125.397 1.00 19.65  ? 137 SER U N    1 
ATOM   980  C CA   . SER A  1 137 ? 130.685 125.338 125.810 1.00 17.45  ? 137 SER U CA   1 
ATOM   981  C C    . SER A  1 137 ? 129.412 126.132 125.557 1.00 24.73  ? 137 SER U C    1 
ATOM   982  O O    . SER A  1 137 ? 128.982 126.919 126.407 1.00 38.69  ? 137 SER U O    1 
ATOM   983  C CB   . SER A  1 137 ? 131.865 125.970 125.079 1.00 26.16  ? 137 SER U CB   1 
ATOM   984  O OG   . SER A  1 137 ? 133.038 125.196 125.248 1.00 33.18  ? 137 SER U OG   1 
ATOM   985  N N    . THR A  1 138 ? 128.792 125.940 124.393 1.00 19.29  ? 138 THR U N    1 
ATOM   986  C CA   . THR A  1 138 ? 127.549 126.643 124.099 1.00 24.56  ? 138 THR U CA   1 
ATOM   987  C C    . THR A  1 138 ? 126.427 126.198 125.029 1.00 23.27  ? 138 THR U C    1 
ATOM   988  O O    . THR A  1 138 ? 125.614 127.021 125.468 1.00 29.21  ? 138 THR U O    1 
ATOM   989  C CB   . THR A  1 138 ? 127.157 126.427 122.640 1.00 27.23  ? 138 THR U CB   1 
ATOM   990  O OG1  . THR A  1 138 ? 128.204 126.911 121.793 1.00 26.68  ? 138 THR U OG1  1 
ATOM   991  C CG2  . THR A  1 138 ? 125.880 127.173 122.321 1.00 25.72  ? 138 THR U CG2  1 
ATOM   992  N N    . ILE A  1 139 ? 126.360 124.902 125.340 1.00 19.80  ? 139 ILE U N    1 
ATOM   993  C CA   . ILE A  1 139 ? 125.341 124.439 126.280 1.00 24.65  ? 139 ILE U CA   1 
ATOM   994  C C    . ILE A  1 139 ? 125.529 125.105 127.639 1.00 30.49  ? 139 ILE U C    1 
ATOM   995  O O    . ILE A  1 139 ? 124.564 125.565 128.269 1.00 33.83  ? 139 ILE U O    1 
ATOM   996  C CB   . ILE A  1 139 ? 125.374 122.905 126.392 1.00 26.16  ? 139 ILE U CB   1 
ATOM   997  C CG1  . ILE A  1 139 ? 125.009 122.269 125.052 1.00 21.75  ? 139 ILE U CG1  1 
ATOM   998  C CG2  . ILE A  1 139 ? 124.435 122.432 127.480 1.00 27.04  ? 139 ILE U CG2  1 
ATOM   999  C CD1  . ILE A  1 139 ? 125.014 120.763 125.077 1.00 21.70  ? 139 ILE U CD1  1 
ATOM   1000 N N    . LEU A  1 140 ? 126.774 125.170 128.112 1.00 22.50  ? 140 LEU U N    1 
ATOM   1001 C CA   . LEU A  1 140 ? 127.048 125.821 129.388 1.00 21.97  ? 140 LEU U CA   1 
ATOM   1002 C C    . LEU A  1 140 ? 126.677 127.296 129.341 1.00 29.41  ? 140 LEU U C    1 
ATOM   1003 O O    . LEU A  1 140 ? 126.146 127.845 130.314 1.00 35.95  ? 140 LEU U O    1 
ATOM   1004 C CB   . LEU A  1 140 ? 128.520 125.648 129.754 1.00 19.85  ? 140 LEU U CB   1 
ATOM   1005 C CG   . LEU A  1 140 ? 128.963 126.249 131.084 1.00 20.20  ? 140 LEU U CG   1 
ATOM   1006 C CD1  . LEU A  1 140 ? 128.229 125.587 132.232 1.00 21.33  ? 140 LEU U CD1  1 
ATOM   1007 C CD2  . LEU A  1 140 ? 130.460 126.105 131.250 1.00 19.46  ? 140 LEU U CD2  1 
ATOM   1008 N N    . PHE A  1 141 ? 126.961 127.958 128.219 1.00 27.72  ? 141 PHE U N    1 
ATOM   1009 C CA   . PHE A  1 141 ? 126.599 129.363 128.078 1.00 24.47  ? 141 PHE U CA   1 
ATOM   1010 C C    . PHE A  1 141 ? 125.092 129.552 128.181 1.00 29.62  ? 141 PHE U C    1 
ATOM   1011 O O    . PHE A  1 141 ? 124.616 130.478 128.850 1.00 32.30  ? 141 PHE U O    1 
ATOM   1012 C CB   . PHE A  1 141 ? 127.123 129.902 126.749 1.00 23.04  ? 141 PHE U CB   1 
ATOM   1013 C CG   . PHE A  1 141 ? 126.849 131.360 126.532 1.00 33.06  ? 141 PHE U CG   1 
ATOM   1014 C CD1  . PHE A  1 141 ? 127.649 132.322 127.116 1.00 26.41  ? 141 PHE U CD1  1 
ATOM   1015 C CD2  . PHE A  1 141 ? 125.798 131.768 125.733 1.00 34.43  ? 141 PHE U CD2  1 
ATOM   1016 C CE1  . PHE A  1 141 ? 127.401 133.661 126.915 1.00 21.72  ? 141 PHE U CE1  1 
ATOM   1017 C CE2  . PHE A  1 141 ? 125.546 133.105 125.528 1.00 30.87  ? 141 PHE U CE2  1 
ATOM   1018 C CZ   . PHE A  1 141 ? 126.349 134.052 126.119 1.00 26.14  ? 141 PHE U CZ   1 
ATOM   1019 N N    . PHE A  1 142 ? 124.322 128.681 127.527 1.00 28.62  ? 142 PHE U N    1 
ATOM   1020 C CA   . PHE A  1 142 ? 122.868 128.784 127.610 1.00 22.89  ? 142 PHE U CA   1 
ATOM   1021 C C    . PHE A  1 142 ? 122.379 128.578 129.039 1.00 30.91  ? 142 PHE U C    1 
ATOM   1022 O O    . PHE A  1 142 ? 121.487 129.297 129.511 1.00 37.28  ? 142 PHE U O    1 
ATOM   1023 C CB   . PHE A  1 142 ? 122.215 127.777 126.666 1.00 26.56  ? 142 PHE U CB   1 
ATOM   1024 C CG   . PHE A  1 142 ? 122.449 128.070 125.213 1.00 28.90  ? 142 PHE U CG   1 
ATOM   1025 C CD1  . PHE A  1 142 ? 122.746 129.352 124.792 1.00 31.62  ? 142 PHE U CD1  1 
ATOM   1026 C CD2  . PHE A  1 142 ? 122.373 127.064 124.269 1.00 30.96  ? 142 PHE U CD2  1 
ATOM   1027 C CE1  . PHE A  1 142 ? 122.963 129.623 123.458 1.00 32.32  ? 142 PHE U CE1  1 
ATOM   1028 C CE2  . PHE A  1 142 ? 122.588 127.331 122.935 1.00 30.30  ? 142 PHE U CE2  1 
ATOM   1029 C CZ   . PHE A  1 142 ? 122.882 128.611 122.530 1.00 28.67  ? 142 PHE U CZ   1 
ATOM   1030 N N    . ASN A  1 143 ? 122.947 127.600 129.747 1.00 33.60  ? 143 ASN U N    1 
ATOM   1031 C CA   . ASN A  1 143 ? 122.536 127.374 131.131 1.00 30.25  ? 143 ASN U CA   1 
ATOM   1032 C C    . ASN A  1 143 ? 122.846 128.585 132.007 1.00 30.75  ? 143 ASN U C    1 
ATOM   1033 O O    . ASN A  1 143 ? 122.022 128.992 132.841 1.00 42.00  ? 143 ASN U O    1 
ATOM   1034 C CB   . ASN A  1 143 ? 123.215 126.126 131.688 1.00 29.51  ? 143 ASN U CB   1 
ATOM   1035 C CG   . ASN A  1 143 ? 122.759 124.861 130.997 1.00 36.49  ? 143 ASN U CG   1 
ATOM   1036 O OD1  . ASN A  1 143 ? 121.678 124.815 130.414 1.00 41.44  ? 143 ASN U OD1  1 
ATOM   1037 N ND2  . ASN A  1 143 ? 123.581 123.823 131.061 1.00 38.04  ? 143 ASN U ND2  1 
ATOM   1038 N N    . LEU A  1 144 ? 124.032 129.171 131.838 1.00 27.71  ? 144 LEU U N    1 
ATOM   1039 C CA   . LEU A  1 144 ? 124.382 130.354 132.615 1.00 29.74  ? 144 LEU U CA   1 
ATOM   1040 C C    . LEU A  1 144 ? 123.441 131.509 132.305 1.00 32.85  ? 144 LEU U C    1 
ATOM   1041 O O    . LEU A  1 144 ? 123.039 132.255 133.207 1.00 39.30  ? 144 LEU U O    1 
ATOM   1042 C CB   . LEU A  1 144 ? 125.831 130.753 132.343 1.00 30.92  ? 144 LEU U CB   1 
ATOM   1043 C CG   . LEU A  1 144 ? 126.894 129.722 132.717 1.00 23.72  ? 144 LEU U CG   1 
ATOM   1044 C CD1  . LEU A  1 144 ? 128.280 130.279 132.468 1.00 23.14  ? 144 LEU U CD1  1 
ATOM   1045 C CD2  . LEU A  1 144 ? 126.738 129.304 134.164 1.00 31.29  ? 144 LEU U CD2  1 
ATOM   1046 N N    . PHE A  1 145 ? 123.081 131.675 131.031 1.00 32.99  ? 145 PHE U N    1 
ATOM   1047 C CA   . PHE A  1 145 ? 122.124 132.715 130.676 1.00 34.43  ? 145 PHE U CA   1 
ATOM   1048 C C    . PHE A  1 145 ? 120.789 132.493 131.368 1.00 33.11  ? 145 PHE U C    1 
ATOM   1049 O O    . PHE A  1 145 ? 120.174 133.443 131.865 1.00 38.42  ? 145 PHE U O    1 
ATOM   1050 C CB   . PHE A  1 145 ? 121.931 132.766 129.162 1.00 35.88  ? 145 PHE U CB   1 
ATOM   1051 C CG   . PHE A  1 145 ? 120.656 133.438 128.743 1.00 41.11  ? 145 PHE U CG   1 
ATOM   1052 C CD1  . PHE A  1 145 ? 120.581 134.813 128.653 1.00 38.89  ? 145 PHE U CD1  1 
ATOM   1053 C CD2  . PHE A  1 145 ? 119.529 132.691 128.450 1.00 36.09  ? 145 PHE U CD2  1 
ATOM   1054 C CE1  . PHE A  1 145 ? 119.409 135.432 128.275 1.00 36.63  ? 145 PHE U CE1  1 
ATOM   1055 C CE2  . PHE A  1 145 ? 118.356 133.305 128.072 1.00 36.25  ? 145 PHE U CE2  1 
ATOM   1056 C CZ   . PHE A  1 145 ? 118.296 134.676 127.983 1.00 37.49  ? 145 PHE U CZ   1 
ATOM   1057 N N    . LEU A  1 146 ? 120.314 131.247 131.395 1.00 33.67  ? 146 LEU U N    1 
ATOM   1058 C CA   . LEU A  1 146 ? 119.043 130.972 132.059 1.00 35.02  ? 146 LEU U CA   1 
ATOM   1059 C C    . LEU A  1 146 ? 119.112 131.317 133.541 1.00 37.38  ? 146 LEU U C    1 
ATOM   1060 O O    . LEU A  1 146 ? 118.179 131.915 134.095 1.00 43.90  ? 146 LEU U O    1 
ATOM   1061 C CB   . LEU A  1 146 ? 118.651 129.509 131.869 1.00 36.60  ? 146 LEU U CB   1 
ATOM   1062 C CG   . LEU A  1 146 ? 117.362 129.093 132.575 1.00 38.39  ? 146 LEU U CG   1 
ATOM   1063 C CD1  . LEU A  1 146 ? 116.217 129.994 132.158 1.00 35.33  ? 146 LEU U CD1  1 
ATOM   1064 C CD2  . LEU A  1 146 ? 117.036 127.642 132.279 1.00 37.37  ? 146 LEU U CD2  1 
ATOM   1065 N N    . GLU A  1 147 ? 120.210 130.948 134.201 1.00 39.33  ? 147 GLU U N    1 
ATOM   1066 C CA   . GLU A  1 147 ? 120.352 131.284 135.615 1.00 36.79  ? 147 GLU U CA   1 
ATOM   1067 C C    . GLU A  1 147 ? 120.342 132.793 135.829 1.00 42.26  ? 147 GLU U C    1 
ATOM   1068 O O    . GLU A  1 147 ? 119.683 133.298 136.749 1.00 48.99  ? 147 GLU U O    1 
ATOM   1069 C CB   . GLU A  1 147 ? 121.635 130.680 136.177 1.00 41.01  ? 147 GLU U CB   1 
ATOM   1070 C CG   . GLU A  1 147 ? 122.001 131.219 137.544 1.00 47.34  ? 147 GLU U CG   1 
ATOM   1071 C CD   . GLU A  1 147 ? 123.375 130.776 137.995 1.00 58.02  ? 147 GLU U CD   1 
ATOM   1072 O OE1  . GLU A  1 147 ? 123.955 129.878 137.350 1.00 59.08  ? 147 GLU U OE1  1 
ATOM   1073 O OE2  . GLU A  1 147 ? 123.878 131.330 138.996 1.00 55.23  ? 147 GLU U OE2  1 
ATOM   1074 N N    . ARG A  1 148 ? 121.073 133.531 134.992 1.00 44.55  ? 148 ARG U N    1 
ATOM   1075 C CA   . ARG A  1 148 ? 121.098 134.984 135.124 1.00 41.65  ? 148 ARG U CA   1 
ATOM   1076 C C    . ARG A  1 148 ? 119.708 135.574 134.930 1.00 40.27  ? 148 ARG U C    1 
ATOM   1077 O O    . ARG A  1 148 ? 119.307 136.496 135.652 1.00 39.39  ? 148 ARG U O    1 
ATOM   1078 C CB   . ARG A  1 148 ? 122.076 135.586 134.118 1.00 36.82  ? 148 ARG U CB   1 
ATOM   1079 C CG   . ARG A  1 148 ? 123.536 135.260 134.376 1.00 32.22  ? 148 ARG U CG   1 
ATOM   1080 C CD   . ARG A  1 148 ? 124.082 136.047 135.550 1.00 34.80  ? 148 ARG U CD   1 
ATOM   1081 N NE   . ARG A  1 148 ? 123.633 135.514 136.828 1.00 42.71  ? 148 ARG U NE   1 
ATOM   1082 C CZ   . ARG A  1 148 ? 123.867 136.087 137.999 1.00 40.27  ? 148 ARG U CZ   1 
ATOM   1083 N NH1  . ARG A  1 148 ? 124.525 137.229 138.090 1.00 40.05  ? 148 ARG U NH1  1 
ATOM   1084 N NH2  . ARG A  1 148 ? 123.426 135.501 139.108 1.00 39.27  ? 148 ARG U NH2  1 
ATOM   1085 N N    . LEU A  1 149 ? 118.961 135.061 133.952 1.00 46.95  ? 149 LEU U N    1 
ATOM   1086 C CA   . LEU A  1 149 ? 117.612 135.560 133.713 1.00 45.22  ? 149 LEU U CA   1 
ATOM   1087 C C    . LEU A  1 149 ? 116.715 135.316 134.917 1.00 42.18  ? 149 LEU U C    1 
ATOM   1088 O O    . LEU A  1 149 ? 115.934 136.192 135.308 1.00 44.37  ? 149 LEU U O    1 
ATOM   1089 C CB   . LEU A  1 149 ? 117.023 134.902 132.468 1.00 42.33  ? 149 LEU U CB   1 
ATOM   1090 C CG   . LEU A  1 149 ? 115.579 135.275 132.145 1.00 40.07  ? 149 LEU U CG   1 
ATOM   1091 C CD1  . LEU A  1 149 ? 115.478 136.752 131.824 1.00 40.43  ? 149 LEU U CD1  1 
ATOM   1092 C CD2  . LEU A  1 149 ? 115.062 134.436 130.995 1.00 41.70  ? 149 LEU U CD2  1 
ATOM   1093 N N    . ILE A  1 150 ? 116.804 134.128 135.514 1.00 41.54  ? 150 ILE U N    1 
ATOM   1094 C CA   . ILE A  1 150 ? 115.988 133.846 136.693 1.00 40.09  ? 150 ILE U CA   1 
ATOM   1095 C C    . ILE A  1 150 ? 116.341 134.801 137.824 1.00 42.60  ? 150 ILE U C    1 
ATOM   1096 O O    . ILE A  1 150 ? 115.457 135.333 138.510 1.00 45.49  ? 150 ILE U O    1 
ATOM   1097 C CB   . ILE A  1 150 ? 116.148 132.377 137.121 1.00 39.46  ? 150 ILE U CB   1 
ATOM   1098 C CG1  . ILE A  1 150 ? 115.534 131.450 136.076 1.00 39.64  ? 150 ILE U CG1  1 
ATOM   1099 C CG2  . ILE A  1 150 ? 115.509 132.150 138.474 1.00 41.05  ? 150 ILE U CG2  1 
ATOM   1100 C CD1  . ILE A  1 150 ? 115.635 129.990 136.431 1.00 40.46  ? 150 ILE U CD1  1 
ATOM   1101 N N    . THR A  1 151 ? 117.637 135.035 138.040 1.00 49.26  ? 151 THR U N    1 
ATOM   1102 C CA   . THR A  1 151 ? 118.042 135.948 139.105 1.00 47.16  ? 151 THR U CA   1 
ATOM   1103 C C    . THR A  1 151 ? 117.509 137.355 138.860 1.00 49.95  ? 151 THR U C    1 
ATOM   1104 O O    . THR A  1 151 ? 117.022 138.015 139.787 1.00 53.23  ? 151 THR U O    1 
ATOM   1105 C CB   . THR A  1 151 ? 119.562 135.975 139.234 1.00 46.21  ? 151 THR U CB   1 
ATOM   1106 O OG1  . THR A  1 151 ? 120.029 134.686 139.646 1.00 53.24  ? 151 THR U OG1  1 
ATOM   1107 C CG2  . THR A  1 151 ? 119.983 137.013 140.256 1.00 44.08  ? 151 THR U CG2  1 
ATOM   1108 N N    . ILE A  1 152 ? 117.595 137.834 137.619 1.00 53.37  ? 152 ILE U N    1 
ATOM   1109 C CA   . ILE A  1 152 ? 117.133 139.186 137.326 1.00 47.55  ? 152 ILE U CA   1 
ATOM   1110 C C    . ILE A  1 152 ? 115.624 139.287 137.505 1.00 51.29  ? 152 ILE U C    1 
ATOM   1111 O O    . ILE A  1 152 ? 115.112 140.299 138.000 1.00 55.21  ? 152 ILE U O    1 
ATOM   1112 C CB   . ILE A  1 152 ? 117.569 139.616 135.915 1.00 48.94  ? 152 ILE U CB   1 
ATOM   1113 C CG1  . ILE A  1 152 ? 117.311 141.107 135.719 1.00 49.42  ? 152 ILE U CG1  1 
ATOM   1114 C CG2  . ILE A  1 152 ? 116.830 138.821 134.862 1.00 45.52  ? 152 ILE U CG2  1 
ATOM   1115 C CD1  . ILE A  1 152 ? 118.024 141.978 136.721 1.00 53.27  ? 152 ILE U CD1  1 
ATOM   1116 N N    . ILE A  1 153 ? 114.886 138.248 137.106 1.00 54.60  ? 153 ILE U N    1 
ATOM   1117 C CA   . ILE A  1 153 ? 113.440 138.257 137.307 1.00 51.32  ? 153 ILE U CA   1 
ATOM   1118 C C    . ILE A  1 153 ? 113.113 138.331 138.792 1.00 52.81  ? 153 ILE U C    1 
ATOM   1119 O O    . ILE A  1 153 ? 112.226 139.085 139.213 1.00 56.28  ? 153 ILE U O    1 
ATOM   1120 C CB   . ILE A  1 153 ? 112.794 137.024 136.654 1.00 49.38  ? 153 ILE U CB   1 
ATOM   1121 C CG1  . ILE A  1 153 ? 112.941 137.078 135.136 1.00 52.56  ? 153 ILE U CG1  1 
ATOM   1122 C CG2  . ILE A  1 153 ? 111.332 136.931 137.037 1.00 48.43  ? 153 ILE U CG2  1 
ATOM   1123 C CD1  . ILE A  1 153 ? 112.286 135.918 134.428 1.00 52.51  ? 153 ILE U CD1  1 
ATOM   1124 N N    . ALA A  1 154 ? 113.812 137.538 139.606 1.00 62.62  ? 154 ALA U N    1 
ATOM   1125 C CA   . ALA A  1 154 ? 113.563 137.572 141.043 1.00 61.53  ? 154 ALA U CA   1 
ATOM   1126 C C    . ALA A  1 154 ? 113.846 138.955 141.613 1.00 59.55  ? 154 ALA U C    1 
ATOM   1127 O O    . ALA A  1 154 ? 113.071 139.475 142.426 1.00 64.01  ? 154 ALA U O    1 
ATOM   1128 C CB   . ALA A  1 154 ? 114.410 136.517 141.752 1.00 60.59  ? 154 ALA U CB   1 
ATOM   1129 N N    . TYR A  1 155 ? 114.954 139.568 141.196 1.00 68.64  ? 155 TYR U N    1 
ATOM   1130 C CA   . TYR A  1 155 ? 115.282 140.899 141.693 1.00 71.01  ? 155 TYR U CA   1 
ATOM   1131 C C    . TYR A  1 155 ? 114.218 141.914 141.294 1.00 71.48  ? 155 TYR U C    1 
ATOM   1132 O O    . TYR A  1 155 ? 113.825 142.764 142.104 1.00 70.91  ? 155 TYR U O    1 
ATOM   1133 C CB   . TYR A  1 155 ? 116.653 141.330 141.178 1.00 70.67  ? 155 TYR U CB   1 
ATOM   1134 C CG   . TYR A  1 155 ? 117.112 142.660 141.723 1.00 72.93  ? 155 TYR U CG   1 
ATOM   1135 C CD1  . TYR A  1 155 ? 116.770 143.846 141.090 1.00 73.30  ? 155 TYR U CD1  1 
ATOM   1136 C CD2  . TYR A  1 155 ? 117.888 142.730 142.870 1.00 74.35  ? 155 TYR U CD2  1 
ATOM   1137 C CE1  . TYR A  1 155 ? 117.186 145.065 141.585 1.00 73.79  ? 155 TYR U CE1  1 
ATOM   1138 C CE2  . TYR A  1 155 ? 118.310 143.944 143.373 1.00 75.80  ? 155 TYR U CE2  1 
ATOM   1139 C CZ   . TYR A  1 155 ? 117.956 145.109 142.726 1.00 76.41  ? 155 TYR U CZ   1 
ATOM   1140 O OH   . TYR A  1 155 ? 118.374 146.322 143.222 1.00 75.59  ? 155 TYR U OH   1 
ATOM   1141 N N    . ILE A  1 156 ? 113.745 141.847 140.049 1.00 69.54  ? 156 ILE U N    1 
ATOM   1142 C CA   . ILE A  1 156 ? 112.725 142.787 139.592 1.00 68.33  ? 156 ILE U CA   1 
ATOM   1143 C C    . ILE A  1 156 ? 111.447 142.619 140.399 1.00 70.12  ? 156 ILE U C    1 
ATOM   1144 O O    . ILE A  1 156 ? 110.820 143.603 140.809 1.00 69.57  ? 156 ILE U O    1 
ATOM   1145 C CB   . ILE A  1 156 ? 112.463 142.613 138.086 1.00 68.06  ? 156 ILE U CB   1 
ATOM   1146 C CG1  . ILE A  1 156 ? 113.713 142.963 137.282 1.00 68.78  ? 156 ILE U CG1  1 
ATOM   1147 C CG2  . ILE A  1 156 ? 111.295 143.476 137.652 1.00 68.48  ? 156 ILE U CG2  1 
ATOM   1148 C CD1  . ILE A  1 156 ? 113.520 142.847 135.790 1.00 68.71  ? 156 ILE U CD1  1 
ATOM   1149 N N    . MET A  1 157 ? 111.026 141.371 140.623 1.00 81.92  ? 157 MET U N    1 
ATOM   1150 C CA   . MET A  1 157 ? 109.817 141.141 141.407 1.00 79.85  ? 157 MET U CA   1 
ATOM   1151 C C    . MET A  1 157 ? 109.973 141.673 142.825 1.00 80.93  ? 157 MET U C    1 
ATOM   1152 O O    . MET A  1 157 ? 109.054 142.302 143.365 1.00 81.75  ? 157 MET U O    1 
ATOM   1153 C CB   . MET A  1 157 ? 109.471 139.654 141.425 1.00 77.36  ? 157 MET U CB   1 
ATOM   1154 C CG   . MET A  1 157 ? 108.882 139.141 140.124 1.00 81.15  ? 157 MET U CG   1 
ATOM   1155 S SD   . MET A  1 157 ? 108.578 137.365 140.146 1.00 90.10  ? 157 MET U SD   1 
ATOM   1156 C CE   . MET A  1 157 ? 107.513 137.219 141.577 1.00 83.38  ? 157 MET U CE   1 
ATOM   1157 N N    . LYS A  1 158 ? 111.130 141.434 143.444 1.00 89.02  ? 158 LYS U N    1 
ATOM   1158 C CA   . LYS A  1 158 ? 111.353 141.935 144.796 1.00 88.73  ? 158 LYS U CA   1 
ATOM   1159 C C    . LYS A  1 158 ? 111.285 143.456 144.831 1.00 89.81  ? 158 LYS U C    1 
ATOM   1160 O O    . LYS A  1 158 ? 110.657 144.040 145.722 1.00 91.36  ? 158 LYS U O    1 
ATOM   1161 C CB   . LYS A  1 158 ? 112.701 141.449 145.324 1.00 88.21  ? 158 LYS U CB   1 
ATOM   1162 C CG   . LYS A  1 158 ? 113.084 142.049 146.666 1.00 89.50  ? 158 LYS U CG   1 
ATOM   1163 C CD   . LYS A  1 158 ? 114.469 141.601 147.099 1.00 90.39  ? 158 LYS U CD   1 
ATOM   1164 C CE   . LYS A  1 158 ? 114.857 142.219 148.430 1.00 87.83  ? 158 LYS U CE   1 
ATOM   1165 N NZ   . LYS A  1 158 ? 113.912 141.834 149.513 1.00 88.09  ? 158 LYS U NZ   1 
ATOM   1166 N N    . SER A  1 159 ? 111.932 144.116 143.869 1.00 91.92  ? 159 SER U N    1 
ATOM   1167 C CA   . SER A  1 159 ? 111.919 145.574 143.846 1.00 92.51  ? 159 SER U CA   1 
ATOM   1168 C C    . SER A  1 159 ? 110.509 146.110 143.641 1.00 93.13  ? 159 SER U C    1 
ATOM   1169 O O    . SER A  1 159 ? 110.102 147.078 144.295 1.00 93.30  ? 159 SER U O    1 
ATOM   1170 C CB   . SER A  1 159 ? 112.851 146.092 142.752 1.00 93.57  ? 159 SER U CB   1 
ATOM   1171 O OG   . SER A  1 159 ? 112.814 147.507 142.685 1.00 93.01  ? 159 SER U OG   1 
ATOM   1172 N N    . CYS A  1 160 ? 109.749 145.499 142.729 1.00 97.35  ? 160 CYS U N    1 
ATOM   1173 C CA   . CYS A  1 160 ? 108.387 145.958 142.485 1.00 98.59  ? 160 CYS U CA   1 
ATOM   1174 C C    . CYS A  1 160 ? 107.522 145.789 143.726 1.00 97.68  ? 160 CYS U C    1 
ATOM   1175 O O    . CYS A  1 160 ? 106.748 146.687 144.078 1.00 98.29  ? 160 CYS U O    1 
ATOM   1176 C CB   . CYS A  1 160 ? 107.783 145.206 141.300 1.00 98.37  ? 160 CYS U CB   1 
ATOM   1177 S SG   . CYS A  1 160 ? 106.088 145.685 140.898 1.00 97.38  ? 160 CYS U SG   1 
ATOM   1178 N N    . HIS A  1 161 ? 107.638 144.645 144.404 1.00 101.32 ? 161 HIS U N    1 
ATOM   1179 C CA   . HIS A  1 161 ? 106.864 144.441 145.624 1.00 103.29 ? 161 HIS U CA   1 
ATOM   1180 C C    . HIS A  1 161 ? 107.259 145.444 146.699 1.00 103.57 ? 161 HIS U C    1 
ATOM   1181 O O    . HIS A  1 161 ? 106.397 145.982 147.402 1.00 103.11 ? 161 HIS U O    1 
ATOM   1182 C CB   . HIS A  1 161 ? 107.045 143.013 146.135 1.00 103.01 ? 161 HIS U CB   1 
ATOM   1183 C CG   . HIS A  1 161 ? 106.369 142.755 147.444 1.00 103.32 ? 161 HIS U CG   1 
ATOM   1184 N ND1  . HIS A  1 161 ? 106.935 143.099 148.653 1.00 102.84 ? 161 HIS U ND1  1 
ATOM   1185 C CD2  . HIS A  1 161 ? 105.173 142.193 147.736 1.00 103.01 ? 161 HIS U CD2  1 
ATOM   1186 C CE1  . HIS A  1 161 ? 106.118 142.757 149.632 1.00 103.25 ? 161 HIS U CE1  1 
ATOM   1187 N NE2  . HIS A  1 161 ? 105.041 142.204 149.103 1.00 104.81 ? 161 HIS U NE2  1 
ATOM   1188 N N    . GLN A  1 162 ? 108.559 145.706 146.845 1.00 107.37 ? 162 GLN U N    1 
ATOM   1189 C CA   . GLN A  1 162 ? 109.002 146.669 147.847 1.00 107.30 ? 162 GLN U CA   1 
ATOM   1190 C C    . GLN A  1 162 ? 108.454 148.057 147.548 1.00 107.71 ? 162 GLN U C    1 
ATOM   1191 O O    . GLN A  1 162 ? 107.996 148.761 148.456 1.00 107.41 ? 162 GLN U O    1 
ATOM   1192 C CB   . GLN A  1 162 ? 110.530 146.689 147.916 1.00 107.01 ? 162 GLN U CB   1 
ATOM   1193 C CG   . GLN A  1 162 ? 111.099 147.471 149.090 1.00 106.96 ? 162 GLN U CG   1 
ATOM   1194 C CD   . GLN A  1 162 ? 111.139 148.965 148.839 1.00 108.30 ? 162 GLN U CD   1 
ATOM   1195 O OE1  . GLN A  1 162 ? 111.002 149.420 147.704 1.00 109.15 ? 162 GLN U OE1  1 
ATOM   1196 N NE2  . GLN A  1 162 ? 111.329 149.739 149.902 1.00 107.26 ? 162 GLN U NE2  1 
ATOM   1197 N N    . ARG A  1 163 ? 108.488 148.470 146.279 1.00 111.16 ? 163 ARG U N    1 
ATOM   1198 C CA   . ARG A  1 163 ? 107.931 149.770 145.920 1.00 111.45 ? 163 ARG U CA   1 
ATOM   1199 C C    . ARG A  1 163 ? 106.435 149.818 146.198 1.00 112.16 ? 163 ARG U C    1 
ATOM   1200 O O    . ARG A  1 163 ? 105.927 150.809 146.735 1.00 111.78 ? 163 ARG U O    1 
ATOM   1201 C CB   . ARG A  1 163 ? 108.211 150.082 144.450 1.00 110.84 ? 163 ARG U CB   1 
ATOM   1202 C CG   . ARG A  1 163 ? 107.591 151.388 143.977 1.00 110.59 ? 163 ARG U CG   1 
ATOM   1203 C CD   . ARG A  1 163 ? 107.838 151.627 142.496 1.00 110.67 ? 163 ARG U CD   1 
ATOM   1204 N NE   . ARG A  1 163 ? 109.255 151.779 142.191 1.00 112.83 ? 163 ARG U NE   1 
ATOM   1205 C CZ   . ARG A  1 163 ? 110.048 150.790 141.802 1.00 113.21 ? 163 ARG U CZ   1 
ATOM   1206 N NH1  . ARG A  1 163 ? 109.593 149.555 141.660 1.00 111.87 ? 163 ARG U NH1  1 
ATOM   1207 N NH2  . ARG A  1 163 ? 111.328 151.045 141.550 1.00 111.89 ? 163 ARG U NH2  1 
ATOM   1208 N N    . GLN A  1 164 ? 105.712 148.753 145.845 1.00 114.48 ? 164 GLN U N    1 
ATOM   1209 C CA   . GLN A  1 164 ? 104.278 148.714 146.100 1.00 115.12 ? 164 GLN U CA   1 
ATOM   1210 C C    . GLN A  1 164 ? 103.959 148.673 147.587 1.00 115.33 ? 164 GLN U C    1 
ATOM   1211 O O    . GLN A  1 164 ? 102.842 149.025 147.979 1.00 114.23 ? 164 GLN U O    1 
ATOM   1212 C CB   . GLN A  1 164 ? 103.650 147.508 145.399 1.00 114.32 ? 164 GLN U CB   1 
ATOM   1213 C CG   . GLN A  1 164 ? 102.135 147.461 145.490 1.00 114.37 ? 164 GLN U CG   1 
ATOM   1214 C CD   . GLN A  1 164 ? 101.477 148.652 144.822 1.00 115.22 ? 164 GLN U CD   1 
ATOM   1215 O OE1  . GLN A  1 164 ? 102.149 149.491 144.221 1.00 114.60 ? 164 GLN U OE1  1 
ATOM   1216 N NE2  . GLN A  1 164 ? 100.156 148.733 144.925 1.00 115.49 ? 164 GLN U NE2  1 
ATOM   1217 N N    . LEU A  1 165 ? 104.913 148.253 148.420 1.00 116.28 ? 165 LEU U N    1 
ATOM   1218 C CA   . LEU A  1 165 ? 104.672 148.217 149.858 1.00 116.62 ? 165 LEU U CA   1 
ATOM   1219 C C    . LEU A  1 165 ? 104.403 149.614 150.404 1.00 116.71 ? 165 LEU U C    1 
ATOM   1220 O O    . LEU A  1 165 ? 103.547 149.793 151.277 1.00 115.35 ? 165 LEU U O    1 
ATOM   1221 C CB   . LEU A  1 165 ? 105.863 147.576 150.573 1.00 116.13 ? 165 LEU U CB   1 
ATOM   1222 C CG   . LEU A  1 165 ? 105.759 147.341 152.083 1.00 116.17 ? 165 LEU U CG   1 
ATOM   1223 C CD1  . LEU A  1 165 ? 105.972 148.629 152.867 1.00 114.98 ? 165 LEU U CD1  1 
ATOM   1224 C CD2  . LEU A  1 165 ? 104.419 146.714 152.431 1.00 115.03 ? 165 LEU U CD2  1 
ATOM   1225 N N    . ARG A  1 166 ? 105.124 150.614 149.899 1.00 118.43 ? 166 ARG U N    1 
ATOM   1226 C CA   . ARG A  1 166 ? 104.954 151.997 150.344 1.00 118.79 ? 166 ARG U CA   1 
ATOM   1227 C C    . ARG A  1 166 ? 103.651 152.536 149.761 1.00 119.23 ? 166 ARG U C    1 
ATOM   1228 O O    . ARG A  1 166 ? 103.619 153.215 148.732 1.00 117.87 ? 166 ARG U O    1 
ATOM   1229 C CB   . ARG A  1 166 ? 106.148 152.847 149.927 1.00 117.99 ? 166 ARG U CB   1 
ATOM   1230 C CG   . ARG A  1 166 ? 106.045 154.303 150.344 1.00 117.03 ? 166 ARG U CG   1 
ATOM   1231 C CD   . ARG A  1 166 ? 107.195 155.116 149.778 1.00 117.19 ? 166 ARG U CD   1 
ATOM   1232 N NE   . ARG A  1 166 ? 107.222 155.073 148.321 1.00 118.74 ? 166 ARG U NE   1 
ATOM   1233 C CZ   . ARG A  1 166 ? 106.554 155.907 147.536 1.00 118.60 ? 166 ARG U CZ   1 
ATOM   1234 N NH1  . ARG A  1 166 ? 105.791 156.865 148.034 1.00 118.49 ? 166 ARG U NH1  1 
ATOM   1235 N NH2  . ARG A  1 166 ? 106.654 155.775 146.216 1.00 117.65 ? 166 ARG U NH2  1 
ATOM   1236 N N    . ARG A  1 167 ? 102.554 152.220 150.440 1.00 117.83 ? 167 ARG U N    1 
ATOM   1237 C CA   . ARG A  1 167 ? 101.232 152.649 150.002 1.00 116.97 ? 167 ARG U CA   1 
ATOM   1238 C C    . ARG A  1 167 ? 100.247 152.653 151.165 1.00 115.10 ? 167 ARG U C    1 
ATOM   1239 O O    . ARG A  1 167 ? 100.344 151.830 152.076 1.00 114.54 ? 167 ARG U O    1 
ATOM   1240 C CB   . ARG A  1 167 ? 100.720 151.743 148.881 1.00 116.82 ? 167 ARG U CB   1 
ATOM   1241 C CG   . ARG A  1 167 ? 99.384  152.172 148.302 1.00 115.75 ? 167 ARG U CG   1 
ATOM   1242 C CD   . ARG A  1 167 ? 99.457  153.588 147.762 1.00 115.49 ? 167 ARG U CD   1 
ATOM   1243 N NE   . ARG A  1 167 ? 100.512 153.736 146.766 1.00 115.93 ? 167 ARG U NE   1 
ATOM   1244 C CZ   . ARG A  1 167 ? 100.812 154.873 146.156 1.00 115.88 ? 167 ARG U CZ   1 
ATOM   1245 N NH1  . ARG A  1 167 ? 100.155 155.992 146.417 1.00 116.17 ? 167 ARG U NH1  1 
ATOM   1246 N NH2  . ARG A  1 167 ? 101.797 154.891 145.263 1.00 114.99 ? 167 ARG U NH2  1 
ATOM   1247 N N    . ALA A  1 188 ? 116.731 136.549 146.664 1.00 91.13  ? 188 ALA U N    1 
ATOM   1248 C CA   . ALA A  1 188 ? 116.732 135.692 147.844 1.00 94.01  ? 188 ALA U CA   1 
ATOM   1249 C C    . ALA A  1 188 ? 115.628 134.642 147.762 1.00 96.22  ? 188 ALA U C    1 
ATOM   1250 O O    . ALA A  1 188 ? 115.759 133.644 147.057 1.00 94.14  ? 188 ALA U O    1 
ATOM   1251 C CB   . ALA A  1 188 ? 116.579 136.528 149.105 1.00 91.82  ? 188 ALA U CB   1 
ATOM   1252 N N    . GLY A  1 189 ? 114.539 134.876 148.491 1.00 95.47  ? 189 GLY U N    1 
ATOM   1253 C CA   . GLY A  1 189 ? 113.417 133.958 148.494 1.00 93.28  ? 189 GLY U CA   1 
ATOM   1254 C C    . GLY A  1 189 ? 112.286 134.389 147.584 1.00 92.89  ? 189 GLY U C    1 
ATOM   1255 O O    . GLY A  1 189 ? 111.150 133.926 147.728 1.00 90.95  ? 189 GLY U O    1 
ATOM   1256 N N    . TRP A  1 190 ? 112.582 135.282 146.642 1.00 90.26  ? 190 TRP U N    1 
ATOM   1257 C CA   . TRP A  1 190 ? 111.589 135.814 145.721 1.00 88.11  ? 190 TRP U CA   1 
ATOM   1258 C C    . TRP A  1 190 ? 111.637 135.153 144.350 1.00 86.77  ? 190 TRP U C    1 
ATOM   1259 O O    . TRP A  1 190 ? 110.987 135.639 143.420 1.00 89.42  ? 190 TRP U O    1 
ATOM   1260 C CB   . TRP A  1 190 ? 111.770 137.325 145.568 1.00 88.65  ? 190 TRP U CB   1 
ATOM   1261 C CG   . TRP A  1 190 ? 111.602 138.086 146.842 1.00 90.14  ? 190 TRP U CG   1 
ATOM   1262 C CD1  . TRP A  1 190 ? 112.533 138.256 147.822 1.00 89.80  ? 190 TRP U CD1  1 
ATOM   1263 C CD2  . TRP A  1 190 ? 110.434 138.793 147.269 1.00 91.15  ? 190 TRP U CD2  1 
ATOM   1264 N NE1  . TRP A  1 190 ? 112.015 139.022 148.837 1.00 89.97  ? 190 TRP U NE1  1 
ATOM   1265 C CE2  . TRP A  1 190 ? 110.727 139.364 148.522 1.00 91.05  ? 190 TRP U CE2  1 
ATOM   1266 C CE3  . TRP A  1 190 ? 109.166 138.995 146.717 1.00 90.24  ? 190 TRP U CE3  1 
ATOM   1267 C CZ2  . TRP A  1 190 ? 109.801 140.124 149.232 1.00 90.40  ? 190 TRP U CZ2  1 
ATOM   1268 C CZ3  . TRP A  1 190 ? 108.249 139.750 147.422 1.00 89.66  ? 190 TRP U CZ3  1 
ATOM   1269 C CH2  . TRP A  1 190 ? 108.570 140.304 148.665 1.00 90.59  ? 190 TRP U CH2  1 
ATOM   1270 N N    . LYS A  1 191 ? 112.384 134.067 144.201 1.00 76.21  ? 191 LYS U N    1 
ATOM   1271 C CA   . LYS A  1 191 ? 112.532 133.459 142.889 1.00 78.68  ? 191 LYS U CA   1 
ATOM   1272 C C    . LYS A  1 191 ? 111.173 133.003 142.364 1.00 77.02  ? 191 LYS U C    1 
ATOM   1273 O O    . LYS A  1 191 ? 110.370 132.444 143.119 1.00 77.94  ? 191 LYS U O    1 
ATOM   1274 C CB   . LYS A  1 191 ? 113.502 132.278 142.947 1.00 79.37  ? 191 LYS U CB   1 
ATOM   1275 C CG   . LYS A  1 191 ? 114.946 132.691 143.165 1.00 81.48  ? 191 LYS U CG   1 
ATOM   1276 C CD   . LYS A  1 191 ? 115.896 131.523 142.974 1.00 81.02  ? 191 LYS U CD   1 
ATOM   1277 C CE   . LYS A  1 191 ? 117.342 131.976 143.069 1.00 79.36  ? 191 LYS U CE   1 
ATOM   1278 N NZ   . LYS A  1 191 ? 118.291 130.853 142.840 1.00 79.78  ? 191 LYS U NZ   1 
ATOM   1279 N N    . PRO A  1 192 ? 110.883 133.225 141.087 1.00 66.02  ? 192 PRO U N    1 
ATOM   1280 C CA   . PRO A  1 192 ? 109.560 132.894 140.558 1.00 66.83  ? 192 PRO U CA   1 
ATOM   1281 C C    . PRO A  1 192 ? 109.376 131.396 140.382 1.00 66.12  ? 192 PRO U C    1 
ATOM   1282 O O    . PRO A  1 192 ? 110.332 130.619 140.335 1.00 66.37  ? 192 PRO U O    1 
ATOM   1283 C CB   . PRO A  1 192 ? 109.533 133.614 139.209 1.00 66.48  ? 192 PRO U CB   1 
ATOM   1284 C CG   . PRO A  1 192 ? 110.960 133.625 138.788 1.00 63.51  ? 192 PRO U CG   1 
ATOM   1285 C CD   . PRO A  1 192 ? 111.767 133.782 140.049 1.00 63.09  ? 192 PRO U CD   1 
ATOM   1286 N N    . SER A  1 193 ? 108.112 130.995 140.284 1.00 56.10  ? 193 SER U N    1 
ATOM   1287 C CA   . SER A  1 193 ? 107.782 129.605 140.030 1.00 52.27  ? 193 SER U CA   1 
ATOM   1288 C C    . SER A  1 193 ? 108.071 129.252 138.573 1.00 54.32  ? 193 SER U C    1 
ATOM   1289 O O    . SER A  1 193 ? 108.332 130.115 137.733 1.00 58.82  ? 193 SER U O    1 
ATOM   1290 C CB   . SER A  1 193 ? 106.316 129.335 140.363 1.00 54.59  ? 193 SER U CB   1 
ATOM   1291 O OG   . SER A  1 193 ? 105.463 130.185 139.619 1.00 57.37  ? 193 SER U OG   1 
ATOM   1292 N N    . VAL A  1 194 ? 108.024 127.953 138.277 1.00 46.31  ? 194 VAL U N    1 
ATOM   1293 C CA   . VAL A  1 194 ? 108.323 127.494 136.926 1.00 47.30  ? 194 VAL U CA   1 
ATOM   1294 C C    . VAL A  1 194 ? 107.285 128.010 135.937 1.00 50.58  ? 194 VAL U C    1 
ATOM   1295 O O    . VAL A  1 194 ? 107.606 128.323 134.786 1.00 53.92  ? 194 VAL U O    1 
ATOM   1296 C CB   . VAL A  1 194 ? 108.418 125.960 136.893 1.00 48.24  ? 194 VAL U CB   1 
ATOM   1297 C CG1  . VAL A  1 194 ? 108.739 125.482 135.492 1.00 48.06  ? 194 VAL U CG1  1 
ATOM   1298 C CG2  . VAL A  1 194 ? 109.467 125.478 137.877 1.00 48.75  ? 194 VAL U CG2  1 
ATOM   1299 N N    . TYR A  1 195 ? 106.027 128.101 136.366 1.00 51.32  ? 195 TYR U N    1 
ATOM   1300 C CA   . TYR A  1 195 ? 104.962 128.531 135.468 1.00 51.84  ? 195 TYR U CA   1 
ATOM   1301 C C    . TYR A  1 195 ? 105.204 129.950 134.960 1.00 57.73  ? 195 TYR U C    1 
ATOM   1302 O O    . TYR A  1 195 ? 105.086 130.225 133.758 1.00 60.18  ? 195 TYR U O    1 
ATOM   1303 C CB   . TYR A  1 195 ? 103.621 128.425 136.192 1.00 51.81  ? 195 TYR U CB   1 
ATOM   1304 C CG   . TYR A  1 195 ? 102.417 128.776 135.358 1.00 59.12  ? 195 TYR U CG   1 
ATOM   1305 C CD1  . TYR A  1 195 ? 101.925 127.895 134.408 1.00 58.77  ? 195 TYR U CD1  1 
ATOM   1306 C CD2  . TYR A  1 195 ? 101.757 129.982 135.536 1.00 57.98  ? 195 TYR U CD2  1 
ATOM   1307 C CE1  . TYR A  1 195 ? 100.821 128.210 133.648 1.00 61.24  ? 195 TYR U CE1  1 
ATOM   1308 C CE2  . TYR A  1 195 ? 100.652 130.307 134.781 1.00 54.06  ? 195 TYR U CE2  1 
ATOM   1309 C CZ   . TYR A  1 195 ? 100.187 129.418 133.840 1.00 59.76  ? 195 TYR U CZ   1 
ATOM   1310 O OH   . TYR A  1 195 ? 99.084  129.741 133.085 1.00 62.48  ? 195 TYR U OH   1 
ATOM   1311 N N    . TYR A  1 196 ? 105.553 130.867 135.863 1.00 55.33  ? 196 TYR U N    1 
ATOM   1312 C CA   . TYR A  1 196 ? 105.783 132.248 135.451 1.00 53.68  ? 196 TYR U CA   1 
ATOM   1313 C C    . TYR A  1 196 ? 107.005 132.361 134.551 1.00 53.91  ? 196 TYR U C    1 
ATOM   1314 O O    . TYR A  1 196 ? 107.003 133.137 133.588 1.00 60.26  ? 196 TYR U O    1 
ATOM   1315 C CB   . TYR A  1 196 ? 105.928 133.145 136.677 1.00 54.27  ? 196 TYR U CB   1 
ATOM   1316 C CG   . TYR A  1 196 ? 104.658 133.261 137.485 1.00 61.24  ? 196 TYR U CG   1 
ATOM   1317 C CD1  . TYR A  1 196 ? 103.436 132.883 136.947 1.00 59.05  ? 196 TYR U CD1  1 
ATOM   1318 C CD2  . TYR A  1 196 ? 104.678 133.749 138.783 1.00 61.33  ? 196 TYR U CD2  1 
ATOM   1319 C CE1  . TYR A  1 196 ? 102.271 132.987 137.679 1.00 59.05  ? 196 TYR U CE1  1 
ATOM   1320 C CE2  . TYR A  1 196 ? 103.518 133.856 139.524 1.00 60.07  ? 196 TYR U CE2  1 
ATOM   1321 C CZ   . TYR A  1 196 ? 102.317 133.474 138.966 1.00 62.05  ? 196 TYR U CZ   1 
ATOM   1322 O OH   . TYR A  1 196 ? 101.157 133.579 139.698 1.00 61.90  ? 196 TYR U OH   1 
ATOM   1323 N N    . VAL A  1 197 ? 108.060 131.603 134.846 1.00 44.66  ? 197 VAL U N    1 
ATOM   1324 C CA   . VAL A  1 197 ? 109.236 131.619 133.984 1.00 42.90  ? 197 VAL U CA   1 
ATOM   1325 C C    . VAL A  1 197 ? 108.877 131.123 132.593 1.00 44.77  ? 197 VAL U C    1 
ATOM   1326 O O    . VAL A  1 197 ? 109.338 131.671 131.584 1.00 48.75  ? 197 VAL U O    1 
ATOM   1327 C CB   . VAL A  1 197 ? 110.373 130.791 134.607 1.00 44.00  ? 197 VAL U CB   1 
ATOM   1328 C CG1  . VAL A  1 197 ? 111.547 130.716 133.654 1.00 44.16  ? 197 VAL U CG1  1 
ATOM   1329 C CG2  . VAL A  1 197 ? 110.799 131.394 135.929 1.00 47.83  ? 197 VAL U CG2  1 
ATOM   1330 N N    . MET A  1 198 ? 108.055 130.074 132.510 1.00 49.12  ? 198 MET U N    1 
ATOM   1331 C CA   . MET A  1 198 ? 107.635 129.579 131.204 1.00 46.24  ? 198 MET U CA   1 
ATOM   1332 C C    . MET A  1 198 ? 106.839 130.633 130.449 1.00 48.90  ? 198 MET U C    1 
ATOM   1333 O O    . MET A  1 198 ? 107.037 130.826 129.244 1.00 55.04  ? 198 MET U O    1 
ATOM   1334 C CB   . MET A  1 198 ? 106.811 128.304 131.356 1.00 50.56  ? 198 MET U CB   1 
ATOM   1335 C CG   . MET A  1 198 ? 106.363 127.719 130.030 1.00 54.79  ? 198 MET U CG   1 
ATOM   1336 S SD   . MET A  1 198 ? 105.125 126.425 130.200 1.00 68.66  ? 198 MET U SD   1 
ATOM   1337 C CE   . MET A  1 198 ? 103.759 127.360 130.879 1.00 53.05  ? 198 MET U CE   1 
ATOM   1338 N N    . LEU A  1 199 ? 105.924 131.319 131.136 1.00 44.14  ? 199 LEU U N    1 
ATOM   1339 C CA   . LEU A  1 199 ? 105.149 132.362 130.468 1.00 45.41  ? 199 LEU U CA   1 
ATOM   1340 C C    . LEU A  1 199 ? 106.055 133.475 129.953 1.00 47.09  ? 199 LEU U C    1 
ATOM   1341 O O    . LEU A  1 199 ? 105.889 133.955 128.824 1.00 49.54  ? 199 LEU U O    1 
ATOM   1342 C CB   . LEU A  1 199 ? 104.094 132.927 131.417 1.00 41.74  ? 199 LEU U CB   1 
ATOM   1343 C CG   . LEU A  1 199 ? 103.017 131.953 131.890 1.00 46.96  ? 199 LEU U CG   1 
ATOM   1344 C CD1  . LEU A  1 199 ? 101.968 132.684 132.709 1.00 48.61  ? 199 LEU U CD1  1 
ATOM   1345 C CD2  . LEU A  1 199 ? 102.380 131.245 130.710 1.00 45.77  ? 199 LEU U CD2  1 
ATOM   1346 N N    . ILE A  1 200 ? 107.021 133.897 130.770 1.00 44.70  ? 200 ILE U N    1 
ATOM   1347 C CA   . ILE A  1 200 ? 107.932 134.962 130.358 1.00 43.51  ? 200 ILE U CA   1 
ATOM   1348 C C    . ILE A  1 200 ? 108.754 134.528 129.154 1.00 45.22  ? 200 ILE U C    1 
ATOM   1349 O O    . ILE A  1 200 ? 108.954 135.300 128.210 1.00 47.74  ? 200 ILE U O    1 
ATOM   1350 C CB   . ILE A  1 200 ? 108.831 135.379 131.535 1.00 39.17  ? 200 ILE U CB   1 
ATOM   1351 C CG1  . ILE A  1 200 ? 108.010 136.109 132.595 1.00 44.52  ? 200 ILE U CG1  1 
ATOM   1352 C CG2  . ILE A  1 200 ? 109.975 136.244 131.044 1.00 38.11  ? 200 ILE U CG2  1 
ATOM   1353 C CD1  . ILE A  1 200 ? 108.814 136.549 133.789 1.00 42.40  ? 200 ILE U CD1  1 
ATOM   1354 N N    . LEU A  1 201 ? 109.254 133.292 129.171 1.00 39.28  ? 201 LEU U N    1 
ATOM   1355 C CA   . LEU A  1 201 ? 110.040 132.808 128.042 1.00 34.64  ? 201 LEU U CA   1 
ATOM   1356 C C    . LEU A  1 201 ? 109.198 132.724 126.776 1.00 41.16  ? 201 LEU U C    1 
ATOM   1357 O O    . LEU A  1 201 ? 109.678 133.044 125.684 1.00 44.92  ? 201 LEU U O    1 
ATOM   1358 C CB   . LEU A  1 201 ? 110.658 131.451 128.372 1.00 36.31  ? 201 LEU U CB   1 
ATOM   1359 C CG   . LEU A  1 201 ? 111.837 131.492 129.341 1.00 36.79  ? 201 LEU U CG   1 
ATOM   1360 C CD1  . LEU A  1 201 ? 112.389 130.101 129.566 1.00 38.71  ? 201 LEU U CD1  1 
ATOM   1361 C CD2  . LEU A  1 201 ? 112.916 132.415 128.813 1.00 37.55  ? 201 LEU U CD2  1 
ATOM   1362 N N    . CYS A  1 202 ? 107.942 132.290 126.897 1.00 45.99  ? 202 CYS U N    1 
ATOM   1363 C CA   . CYS A  1 202 ? 107.070 132.239 125.728 1.00 41.79  ? 202 CYS U CA   1 
ATOM   1364 C C    . CYS A  1 202 ? 106.847 133.631 125.152 1.00 43.46  ? 202 CYS U C    1 
ATOM   1365 O O    . CYS A  1 202 ? 106.916 133.832 123.932 1.00 44.18  ? 202 CYS U O    1 
ATOM   1366 C CB   . CYS A  1 202 ? 105.735 131.590 126.092 1.00 37.76  ? 202 CYS U CB   1 
ATOM   1367 S SG   . CYS A  1 202 ? 105.831 129.826 126.449 1.00 58.80  ? 202 CYS U SG   1 
ATOM   1368 N N    . THR A  1 203 ? 106.579 134.609 126.018 1.00 39.83  ? 203 THR U N    1 
ATOM   1369 C CA   . THR A  1 203 ? 106.379 135.971 125.533 1.00 36.31  ? 203 THR U CA   1 
ATOM   1370 C C    . THR A  1 203 ? 107.635 136.502 124.855 1.00 43.48  ? 203 THR U C    1 
ATOM   1371 O O    . THR A  1 203 ? 107.560 137.126 123.788 1.00 42.26  ? 203 THR U O    1 
ATOM   1372 C CB   . THR A  1 203 ? 105.967 136.886 126.683 1.00 37.55  ? 203 THR U CB   1 
ATOM   1373 O OG1  . THR A  1 203 ? 104.725 136.433 127.232 1.00 48.26  ? 203 THR U OG1  1 
ATOM   1374 C CG2  . THR A  1 203 ? 105.803 138.309 126.191 1.00 39.94  ? 203 THR U CG2  1 
ATOM   1375 N N    . ALA A  1 204 ? 108.800 136.262 125.457 1.00 47.49  ? 204 ALA U N    1 
ATOM   1376 C CA   . ALA A  1 204 ? 110.045 136.732 124.861 1.00 36.69  ? 204 ALA U CA   1 
ATOM   1377 C C    . ALA A  1 204 ? 110.285 136.082 123.507 1.00 40.74  ? 204 ALA U C    1 
ATOM   1378 O O    . ALA A  1 204 ? 110.708 136.750 122.557 1.00 48.75  ? 204 ALA U O    1 
ATOM   1379 C CB   . ALA A  1 204 ? 111.216 136.459 125.803 1.00 38.87  ? 204 ALA U CB   1 
ATOM   1380 N N    . SER A  1 205 ? 110.030 134.777 123.398 1.00 42.19  ? 205 SER U N    1 
ATOM   1381 C CA   . SER A  1 205 ? 110.224 134.092 122.126 1.00 40.99  ? 205 SER U CA   1 
ATOM   1382 C C    . SER A  1 205 ? 109.294 134.644 121.057 1.00 40.14  ? 205 SER U C    1 
ATOM   1383 O O    . SER A  1 205 ? 109.712 134.865 119.914 1.00 39.58  ? 205 SER U O    1 
ATOM   1384 C CB   . SER A  1 205 ? 110.008 132.591 122.299 1.00 36.02  ? 205 SER U CB   1 
ATOM   1385 O OG   . SER A  1 205 ? 110.898 132.060 123.262 1.00 42.75  ? 205 SER U OG   1 
ATOM   1386 N N    . ILE A  1 206 ? 108.028 134.875 121.406 1.00 41.06  ? 206 ILE U N    1 
ATOM   1387 C CA   . ILE A  1 206 ? 107.088 135.423 120.432 1.00 38.26  ? 206 ILE U CA   1 
ATOM   1388 C C    . ILE A  1 206 ? 107.549 136.799 119.970 1.00 40.49  ? 206 ILE U C    1 
ATOM   1389 O O    . ILE A  1 206 ? 107.544 137.106 118.771 1.00 44.14  ? 206 ILE U O    1 
ATOM   1390 C CB   . ILE A  1 206 ? 105.669 135.476 121.021 1.00 42.71  ? 206 ILE U CB   1 
ATOM   1391 C CG1  . ILE A  1 206 ? 105.108 134.065 121.182 1.00 43.44  ? 206 ILE U CG1  1 
ATOM   1392 C CG2  . ILE A  1 206 ? 104.761 136.309 120.140 1.00 40.98  ? 206 ILE U CG2  1 
ATOM   1393 C CD1  . ILE A  1 206 ? 103.695 134.033 121.708 1.00 43.37  ? 206 ILE U CD1  1 
ATOM   1394 N N    . LEU A  1 207 ? 107.956 137.651 120.915 1.00 40.81  ? 207 LEU U N    1 
ATOM   1395 C CA   . LEU A  1 207 ? 108.394 138.992 120.545 1.00 39.45  ? 207 LEU U CA   1 
ATOM   1396 C C    . LEU A  1 207 ? 109.628 138.947 119.656 1.00 42.24  ? 207 LEU U C    1 
ATOM   1397 O O    . LEU A  1 207 ? 109.716 139.683 118.667 1.00 42.83  ? 207 LEU U O    1 
ATOM   1398 C CB   . LEU A  1 207 ? 108.666 139.824 121.795 1.00 43.80  ? 207 LEU U CB   1 
ATOM   1399 C CG   . LEU A  1 207 ? 107.435 140.218 122.609 1.00 48.71  ? 207 LEU U CG   1 
ATOM   1400 C CD1  . LEU A  1 207 ? 107.826 141.136 123.752 1.00 43.39  ? 207 LEU U CD1  1 
ATOM   1401 C CD2  . LEU A  1 207 ? 106.398 140.876 121.717 1.00 43.41  ? 207 LEU U CD2  1 
ATOM   1402 N N    . ILE A  1 208 ? 110.596 138.092 119.991 1.00 37.79  ? 208 ILE U N    1 
ATOM   1403 C CA   . ILE A  1 208 ? 111.812 138.009 119.190 1.00 37.41  ? 208 ILE U CA   1 
ATOM   1404 C C    . ILE A  1 208 ? 111.497 137.507 117.790 1.00 40.63  ? 208 ILE U C    1 
ATOM   1405 O O    . ILE A  1 208 ? 112.024 138.026 116.798 1.00 41.81  ? 208 ILE U O    1 
ATOM   1406 C CB   . ILE A  1 208 ? 112.857 137.119 119.887 1.00 37.44  ? 208 ILE U CB   1 
ATOM   1407 C CG1  . ILE A  1 208 ? 113.303 137.755 121.200 1.00 39.83  ? 208 ILE U CG1  1 
ATOM   1408 C CG2  . ILE A  1 208 ? 114.049 136.901 118.980 1.00 37.97  ? 208 ILE U CG2  1 
ATOM   1409 C CD1  . ILE A  1 208 ? 114.369 136.970 121.918 1.00 37.03  ? 208 ILE U CD1  1 
ATOM   1410 N N    . SER A  1 209 ? 110.643 136.488 117.679 1.00 45.15  ? 209 SER U N    1 
ATOM   1411 C CA   . SER A  1 209 ? 110.294 135.965 116.363 1.00 34.86  ? 209 SER U CA   1 
ATOM   1412 C C    . SER A  1 209 ? 109.598 137.024 115.522 1.00 33.42  ? 209 SER U C    1 
ATOM   1413 O O    . SER A  1 209 ? 109.914 137.201 114.339 1.00 40.45  ? 209 SER U O    1 
ATOM   1414 C CB   . SER A  1 209 ? 109.414 134.726 116.507 1.00 33.52  ? 209 SER U CB   1 
ATOM   1415 O OG   . SER A  1 209 ? 110.108 133.686 117.170 1.00 43.73  ? 209 SER U OG   1 
ATOM   1416 N N    . CYS A  1 210 ? 108.646 137.747 116.114 1.00 38.57  ? 210 CYS U N    1 
ATOM   1417 C CA   . CYS A  1 210 ? 107.941 138.775 115.357 1.00 36.12  ? 210 CYS U CA   1 
ATOM   1418 C C    . CYS A  1 210 ? 108.880 139.897 114.936 1.00 38.54  ? 210 CYS U C    1 
ATOM   1419 O O    . CYS A  1 210 ? 108.802 140.384 113.803 1.00 37.99  ? 210 CYS U O    1 
ATOM   1420 C CB   . CYS A  1 210 ? 106.772 139.322 116.171 1.00 36.32  ? 210 CYS U CB   1 
ATOM   1421 S SG   . CYS A  1 210 ? 105.419 138.149 116.389 1.00 48.25  ? 210 CYS U SG   1 
ATOM   1422 N N    . CYS A  1 211 ? 109.777 140.324 115.828 1.00 44.99  ? 211 CYS U N    1 
ATOM   1423 C CA   . CYS A  1 211 ? 110.711 141.386 115.468 1.00 42.89  ? 211 CYS U CA   1 
ATOM   1424 C C    . CYS A  1 211 ? 111.658 140.940 114.363 1.00 41.91  ? 211 CYS U C    1 
ATOM   1425 O O    . CYS A  1 211 ? 111.932 141.702 113.430 1.00 46.46  ? 211 CYS U O    1 
ATOM   1426 C CB   . CYS A  1 211 ? 111.493 141.841 116.698 1.00 46.03  ? 211 CYS U CB   1 
ATOM   1427 S SG   . CYS A  1 211 ? 110.488 142.686 117.936 1.00 61.23  ? 211 CYS U SG   1 
ATOM   1428 N N    . ALA A  1 212 ? 112.174 139.712 114.447 1.00 36.73  ? 212 ALA U N    1 
ATOM   1429 C CA   . ALA A  1 212 ? 113.058 139.216 113.400 1.00 33.46  ? 212 ALA U CA   1 
ATOM   1430 C C    . ALA A  1 212 ? 112.329 139.121 112.067 1.00 37.98  ? 212 ALA U C    1 
ATOM   1431 O O    . ALA A  1 212 ? 112.869 139.514 111.028 1.00 33.27  ? 212 ALA U O    1 
ATOM   1432 C CB   . ALA A  1 212 ? 113.636 137.859 113.794 1.00 28.61  ? 212 ALA U CB   1 
ATOM   1433 N N    . SER A  1 213 ? 111.099 138.605 112.077 1.00 38.11  ? 213 SER U N    1 
ATOM   1434 C CA   . SER A  1 213 ? 110.322 138.527 110.848 1.00 25.21  ? 213 SER U CA   1 
ATOM   1435 C C    . SER A  1 213 ? 109.916 139.900 110.335 1.00 33.01  ? 213 SER U C    1 
ATOM   1436 O O    . SER A  1 213 ? 109.569 140.026 109.157 1.00 33.80  ? 213 SER U O    1 
ATOM   1437 C CB   . SER A  1 213 ? 109.083 137.667 111.067 1.00 31.20  ? 213 SER U CB   1 
ATOM   1438 O OG   . SER A  1 213 ? 109.444 136.387 111.550 1.00 41.35  ? 213 SER U OG   1 
ATOM   1439 N N    . ALA A  1 214 ? 109.940 140.927 111.187 1.00 40.78  ? 214 ALA U N    1 
ATOM   1440 C CA   . ALA A  1 214 ? 109.723 142.283 110.697 1.00 33.07  ? 214 ALA U CA   1 
ATOM   1441 C C    . ALA A  1 214 ? 110.674 142.588 109.552 1.00 37.51  ? 214 ALA U C    1 
ATOM   1442 O O    . ALA A  1 214 ? 110.288 143.216 108.561 1.00 41.94  ? 214 ALA U O    1 
ATOM   1443 C CB   . ALA A  1 214 ? 109.896 143.292 111.831 1.00 34.86  ? 214 ALA U CB   1 
ATOM   1444 N N    . MET A  1 215 ? 111.923 142.153 109.676 1.00 41.91  ? 215 MET U N    1 
ATOM   1445 C CA   . MET A  1 215 ? 112.823 142.054 108.543 1.00 42.32  ? 215 MET U CA   1 
ATOM   1446 C C    . MET A  1 215 ? 112.858 140.600 108.080 1.00 48.69  ? 215 MET U C    1 
ATOM   1447 O O    . MET A  1 215 ? 112.123 139.746 108.576 1.00 57.69  ? 215 MET U O    1 
ATOM   1448 C CB   . MET A  1 215 ? 114.216 142.578 108.897 1.00 38.79  ? 215 MET U CB   1 
ATOM   1449 C CG   . MET A  1 215 ? 115.079 141.612 109.676 1.00 47.88  ? 215 MET U CG   1 
ATOM   1450 S SD   . MET A  1 215 ? 116.748 142.247 109.912 1.00 56.94  ? 215 MET U SD   1 
ATOM   1451 C CE   . MET A  1 215 ? 117.555 140.812 110.609 1.00 40.75  ? 215 MET U CE   1 
ATOM   1452 N N    . TYR A  1 216 ? 113.715 140.312 107.114 1.00 32.37  ? 216 TYR U N    1 
ATOM   1453 C CA   . TYR A  1 216 ? 113.705 138.968 106.505 1.00 37.48  ? 216 TYR U CA   1 
ATOM   1454 C C    . TYR A  1 216 ? 112.508 138.913 105.554 1.00 40.15  ? 216 TYR U C    1 
ATOM   1455 O O    . TYR A  1 216 ? 112.468 137.978 104.793 1.00 47.86  ? 216 TYR U O    1 
ATOM   1456 C CB   . TYR A  1 216 ? 113.587 137.808 107.490 1.00 27.88  ? 216 TYR U CB   1 
ATOM   1457 C CG   . TYR A  1 216 ? 114.735 137.432 108.384 1.00 31.56  ? 216 TYR U CG   1 
ATOM   1458 C CD1  . TYR A  1 216 ? 116.021 137.888 108.179 1.00 38.71  ? 216 TYR U CD1  1 
ATOM   1459 C CD2  . TYR A  1 216 ? 114.511 136.570 109.440 1.00 32.45  ? 216 TYR U CD2  1 
ATOM   1460 C CE1  . TYR A  1 216 ? 117.052 137.509 109.020 1.00 37.31  ? 216 TYR U CE1  1 
ATOM   1461 C CE2  . TYR A  1 216 ? 115.527 136.180 110.288 1.00 33.95  ? 216 TYR U CE2  1 
ATOM   1462 C CZ   . TYR A  1 216 ? 116.804 136.654 110.076 1.00 37.48  ? 216 TYR U CZ   1 
ATOM   1463 O OH   . TYR A  1 216 ? 117.795 136.257 110.928 1.00 38.93  ? 216 TYR U OH   1 
ATOM   1464 N N    . THR A  1 217 ? 111.575 139.862 105.580 1.00 36.00  ? 217 THR U N    1 
ATOM   1465 C CA   . THR A  1 217 ? 110.451 139.881 104.655 1.00 33.97  ? 217 THR U CA   1 
ATOM   1466 C C    . THR A  1 217 ? 110.775 140.750 103.448 1.00 40.30  ? 217 THR U C    1 
ATOM   1467 O O    . THR A  1 217 ? 110.621 140.308 102.304 1.00 44.95  ? 217 THR U O    1 
ATOM   1468 C CB   . THR A  1 217 ? 109.184 140.370 105.351 1.00 37.72  ? 217 THR U CB   1 
ATOM   1469 O OG1  . THR A  1 217 ? 108.832 139.452 106.391 1.00 37.82  ? 217 THR U OG1  1 
ATOM   1470 C CG2  . THR A  1 217 ? 108.042 140.457 104.361 1.00 38.27  ? 217 THR U CG2  1 
ATOM   1471 N N    . PRO A  1 218 ? 111.221 141.986 103.659 1.00 38.24  ? 218 PRO U N    1 
ATOM   1472 C CA   . PRO A  1 218 ? 111.595 142.831 102.520 1.00 38.84  ? 218 PRO U CA   1 
ATOM   1473 C C    . PRO A  1 218 ? 113.014 142.572 102.048 1.00 40.14  ? 218 PRO U C    1 
ATOM   1474 O O    . PRO A  1 218 ? 113.321 142.730 100.863 1.00 43.86  ? 218 PRO U O    1 
ATOM   1475 C CB   . PRO A  1 218 ? 111.436 144.248 103.079 1.00 38.62  ? 218 PRO U CB   1 
ATOM   1476 C CG   . PRO A  1 218 ? 111.732 144.095 104.524 1.00 37.61  ? 218 PRO U CG   1 
ATOM   1477 C CD   . PRO A  1 218 ? 111.217 142.740 104.924 1.00 31.84  ? 218 PRO U CD   1 
ATOM   1478 N N    . ILE A  1 219 ? 113.893 142.147 102.952 1.00 37.17  ? 219 ILE U N    1 
ATOM   1479 C CA   . ILE A  1 219 ? 115.319 141.934 102.572 1.00 37.78  ? 219 ILE U CA   1 
ATOM   1480 C C    . ILE A  1 219 ? 115.450 140.586 101.863 1.00 40.18  ? 219 ILE U C    1 
ATOM   1481 O O    . ILE A  1 219 ? 116.223 140.514 100.920 1.00 46.61  ? 219 ILE U O    1 
ATOM   1482 C CB   . ILE A  1 219 ? 116.259 142.043 103.783 1.00 36.12  ? 219 ILE U CB   1 
ATOM   1483 C CG1  . ILE A  1 219 ? 115.847 143.175 104.722 1.00 38.67  ? 219 ILE U CG1  1 
ATOM   1484 C CG2  . ILE A  1 219 ? 117.699 142.192 103.331 1.00 32.41  ? 219 ILE U CG2  1 
ATOM   1485 C CD1  . ILE A  1 219 ? 116.186 144.543 104.201 1.00 37.81  ? 219 ILE U CD1  1 
ATOM   1486 N N    . GLU A  1 220 ? 114.709 139.571 102.284 1.00 40.18  ? 220 GLU U N    1 
ATOM   1487 C CA   . GLU A  1 220 ? 114.819 138.248 101.684 1.00 40.33  ? 220 GLU U CA   1 
ATOM   1488 C C    . GLU A  1 220 ? 113.719 137.965 100.670 1.00 43.63  ? 220 GLU U C    1 
ATOM   1489 O O    . GLU A  1 220 ? 113.745 136.910 100.026 1.00 52.26  ? 220 GLU U O    1 
ATOM   1490 C CB   . GLU A  1 220 ? 114.800 137.172 102.772 1.00 34.74  ? 220 GLU U CB   1 
ATOM   1491 C CG   . GLU A  1 220 ? 115.831 137.362 103.863 1.00 40.54  ? 220 GLU U CG   1 
ATOM   1492 C CD   . GLU A  1 220 ? 117.207 136.906 103.447 1.00 45.11  ? 220 GLU U CD   1 
ATOM   1493 O OE1  . GLU A  1 220 ? 117.357 136.430 102.304 1.00 58.12  ? 220 GLU U OE1  1 
ATOM   1494 O OE2  . GLU A  1 220 ? 118.142 137.017 104.265 1.00 44.20  ? 220 GLU U OE2  1 
ATOM   1495 N N    . GLY A  1 221 ? 112.760 138.868 100.509 1.00 44.06  ? 221 GLY U N    1 
ATOM   1496 C CA   . GLY A  1 221 ? 111.644 138.598 99.617  1.00 43.22  ? 221 GLY U CA   1 
ATOM   1497 C C    . GLY A  1 221 ? 110.820 137.400 100.030 1.00 45.83  ? 221 GLY U C    1 
ATOM   1498 O O    . GLY A  1 221 ? 110.322 136.662 99.170  1.00 51.92  ? 221 GLY U O    1 
ATOM   1499 N N    . TRP A  1 222 ? 110.662 137.188 101.331 1.00 33.94  ? 222 TRP U N    1 
ATOM   1500 C CA   . TRP A  1 222 ? 109.867 136.093 101.864 1.00 33.95  ? 222 TRP U CA   1 
ATOM   1501 C C    . TRP A  1 222 ? 108.508 136.601 102.321 1.00 43.06  ? 222 TRP U C    1 
ATOM   1502 O O    . TRP A  1 222 ? 108.331 137.788 102.601 1.00 50.21  ? 222 TRP U O    1 
ATOM   1503 C CB   . TRP A  1 222 ? 110.574 135.424 103.045 1.00 25.85  ? 222 TRP U CB   1 
ATOM   1504 C CG   . TRP A  1 222 ? 111.806 134.670 102.689 1.00 34.61  ? 222 TRP U CG   1 
ATOM   1505 C CD1  . TRP A  1 222 ? 112.201 134.286 101.446 1.00 39.45  ? 222 TRP U CD1  1 
ATOM   1506 C CD2  . TRP A  1 222 ? 112.812 134.204 103.592 1.00 34.84  ? 222 TRP U CD2  1 
ATOM   1507 N NE1  . TRP A  1 222 ? 113.391 133.605 101.517 1.00 34.94  ? 222 TRP U NE1  1 
ATOM   1508 C CE2  . TRP A  1 222 ? 113.787 133.545 102.826 1.00 30.98  ? 222 TRP U CE2  1 
ATOM   1509 C CE3  . TRP A  1 222 ? 112.983 134.282 104.977 1.00 35.22  ? 222 TRP U CE3  1 
ATOM   1510 C CZ2  . TRP A  1 222 ? 114.916 132.966 103.395 1.00 32.11  ? 222 TRP U CZ2  1 
ATOM   1511 C CZ3  . TRP A  1 222 ? 114.103 133.708 105.540 1.00 29.64  ? 222 TRP U CZ3  1 
ATOM   1512 C CH2  . TRP A  1 222 ? 115.055 133.059 104.751 1.00 27.95  ? 222 TRP U CH2  1 
ATOM   1513 N N    . SER A  1 223 ? 107.545 135.689 102.389 1.00 36.14  ? 223 SER U N    1 
ATOM   1514 C CA   . SER A  1 223 ? 106.283 135.996 103.041 1.00 29.24  ? 223 SER U CA   1 
ATOM   1515 C C    . SER A  1 223 ? 106.469 135.983 104.552 1.00 38.17  ? 223 SER U C    1 
ATOM   1516 O O    . SER A  1 223 ? 107.380 135.342 105.082 1.00 46.77  ? 223 SER U O    1 
ATOM   1517 C CB   . SER A  1 223 ? 105.207 134.993 102.633 1.00 37.17  ? 223 SER U CB   1 
ATOM   1518 O OG   . SER A  1 223 ? 105.577 133.678 103.000 1.00 44.26  ? 223 SER U OG   1 
ATOM   1519 N N    . TYR A  1 224 ? 105.592 136.700 105.254 1.00 35.01  ? 224 TYR U N    1 
ATOM   1520 C CA   . TYR A  1 224 ? 105.739 136.813 106.701 1.00 34.28  ? 224 TYR U CA   1 
ATOM   1521 C C    . TYR A  1 224 ? 105.662 135.448 107.372 1.00 38.90  ? 224 TYR U C    1 
ATOM   1522 O O    . TYR A  1 224 ? 106.442 135.147 108.285 1.00 40.58  ? 224 TYR U O    1 
ATOM   1523 C CB   . TYR A  1 224 ? 104.675 137.753 107.263 1.00 35.09  ? 224 TYR U CB   1 
ATOM   1524 C CG   . TYR A  1 224 ? 104.978 138.238 108.657 1.00 42.56  ? 224 TYR U CG   1 
ATOM   1525 C CD1  . TYR A  1 224 ? 105.728 139.383 108.865 1.00 41.74  ? 224 TYR U CD1  1 
ATOM   1526 C CD2  . TYR A  1 224 ? 104.517 137.548 109.768 1.00 42.28  ? 224 TYR U CD2  1 
ATOM   1527 C CE1  . TYR A  1 224 ? 106.010 139.828 110.138 1.00 38.81  ? 224 TYR U CE1  1 
ATOM   1528 C CE2  . TYR A  1 224 ? 104.795 137.986 111.045 1.00 38.74  ? 224 TYR U CE2  1 
ATOM   1529 C CZ   . TYR A  1 224 ? 105.542 139.126 111.223 1.00 38.84  ? 224 TYR U CZ   1 
ATOM   1530 O OH   . TYR A  1 224 ? 105.820 139.567 112.494 1.00 42.92  ? 224 TYR U OH   1 
ATOM   1531 N N    . PHE A  1 225 ? 104.728 134.602 106.930 1.00 38.38  ? 225 PHE U N    1 
ATOM   1532 C CA   . PHE A  1 225 ? 104.614 133.272 107.514 1.00 38.43  ? 225 PHE U CA   1 
ATOM   1533 C C    . PHE A  1 225 ? 105.873 132.453 107.268 1.00 40.55  ? 225 PHE U C    1 
ATOM   1534 O O    . PHE A  1 225 ? 106.304 131.689 108.139 1.00 44.53  ? 225 PHE U O    1 
ATOM   1535 C CB   . PHE A  1 225 ? 103.388 132.553 106.960 1.00 39.92  ? 225 PHE U CB   1 
ATOM   1536 C CG   . PHE A  1 225 ? 103.256 131.140 107.444 1.00 45.35  ? 225 PHE U CG   1 
ATOM   1537 C CD1  . PHE A  1 225 ? 103.045 130.873 108.784 1.00 40.86  ? 225 PHE U CD1  1 
ATOM   1538 C CD2  . PHE A  1 225 ? 103.347 130.081 106.562 1.00 41.24  ? 225 PHE U CD2  1 
ATOM   1539 C CE1  . PHE A  1 225 ? 102.929 129.579 109.234 1.00 37.29  ? 225 PHE U CE1  1 
ATOM   1540 C CE2  . PHE A  1 225 ? 103.229 128.783 107.008 1.00 40.63  ? 225 PHE U CE2  1 
ATOM   1541 C CZ   . PHE A  1 225 ? 103.020 128.533 108.346 1.00 41.49  ? 225 PHE U CZ   1 
ATOM   1542 N N    . ASP A  1 226 ? 106.477 132.589 106.086 1.00 31.58  ? 226 ASP U N    1 
ATOM   1543 C CA   . ASP A  1 226 ? 107.741 131.908 105.833 1.00 33.29  ? 226 ASP U CA   1 
ATOM   1544 C C    . ASP A  1 226 ? 108.824 132.399 106.783 1.00 39.70  ? 226 ASP U C    1 
ATOM   1545 O O    . ASP A  1 226 ? 109.653 131.611 107.251 1.00 44.66  ? 226 ASP U O    1 
ATOM   1546 C CB   . ASP A  1 226 ? 108.172 132.111 104.383 1.00 36.27  ? 226 ASP U CB   1 
ATOM   1547 C CG   . ASP A  1 226 ? 107.446 131.191 103.428 1.00 42.99  ? 226 ASP U CG   1 
ATOM   1548 O OD1  . ASP A  1 226 ? 106.627 130.375 103.898 1.00 44.85  ? 226 ASP U OD1  1 
ATOM   1549 O OD2  . ASP A  1 226 ? 107.696 131.282 102.209 1.00 43.28  ? 226 ASP U OD2  1 
ATOM   1550 N N    . SER A  1 227 ? 108.841 133.701 107.073 1.00 34.31  ? 227 SER U N    1 
ATOM   1551 C CA   . SER A  1 227 ? 109.812 134.225 108.024 1.00 30.91  ? 227 SER U CA   1 
ATOM   1552 C C    . SER A  1 227 ? 109.607 133.624 109.407 1.00 34.03  ? 227 SER U C    1 
ATOM   1553 O O    . SER A  1 227 ? 110.574 133.244 110.075 1.00 35.43  ? 227 SER U O    1 
ATOM   1554 C CB   . SER A  1 227 ? 109.720 135.748 108.082 1.00 37.01  ? 227 SER U CB   1 
ATOM   1555 O OG   . SER A  1 227 ? 109.997 136.319 106.818 1.00 40.08  ? 227 SER U OG   1 
ATOM   1556 N N    . LEU A  1 228 ? 108.354 133.526 109.857 1.00 32.17  ? 228 LEU U N    1 
ATOM   1557 C CA   . LEU A  1 228 ? 108.092 132.913 111.157 1.00 29.52  ? 228 LEU U CA   1 
ATOM   1558 C C    . LEU A  1 228 ? 108.510 131.447 111.171 1.00 29.10  ? 228 LEU U C    1 
ATOM   1559 O O    . LEU A  1 228 ? 109.074 130.959 112.158 1.00 36.96  ? 228 LEU U O    1 
ATOM   1560 C CB   . LEU A  1 228 ? 106.615 133.048 111.516 1.00 32.44  ? 228 LEU U CB   1 
ATOM   1561 C CG   . LEU A  1 228 ? 106.104 134.462 111.772 1.00 35.71  ? 228 LEU U CG   1 
ATOM   1562 C CD1  . LEU A  1 228 ? 104.613 134.444 112.031 1.00 31.49  ? 228 LEU U CD1  1 
ATOM   1563 C CD2  . LEU A  1 228 ? 106.841 135.082 112.940 1.00 36.11  ? 228 LEU U CD2  1 
ATOM   1564 N N    . TYR A  1 229 ? 108.221 130.727 110.088 1.00 21.50  ? 229 TYR U N    1 
ATOM   1565 C CA   . TYR A  1 229 ? 108.608 129.324 110.000 1.00 23.19  ? 229 TYR U CA   1 
ATOM   1566 C C    . TYR A  1 229 ? 110.120 129.167 110.074 1.00 25.79  ? 229 TYR U C    1 
ATOM   1567 O O    . TYR A  1 229 ? 110.630 128.300 110.795 1.00 25.39  ? 229 TYR U O    1 
ATOM   1568 C CB   . TYR A  1 229 ? 108.054 128.728 108.707 1.00 21.53  ? 229 TYR U CB   1 
ATOM   1569 C CG   . TYR A  1 229 ? 108.524 127.331 108.393 1.00 27.48  ? 229 TYR U CG   1 
ATOM   1570 C CD1  . TYR A  1 229 ? 108.017 126.238 109.075 1.00 22.63  ? 229 TYR U CD1  1 
ATOM   1571 C CD2  . TYR A  1 229 ? 109.457 127.104 107.396 1.00 30.75  ? 229 TYR U CD2  1 
ATOM   1572 C CE1  . TYR A  1 229 ? 108.438 124.961 108.783 1.00 20.26  ? 229 TYR U CE1  1 
ATOM   1573 C CE2  . TYR A  1 229 ? 109.884 125.831 107.098 1.00 31.26  ? 229 TYR U CE2  1 
ATOM   1574 C CZ   . TYR A  1 229 ? 109.372 124.764 107.794 1.00 26.33  ? 229 TYR U CZ   1 
ATOM   1575 O OH   . TYR A  1 229 ? 109.796 123.492 107.497 1.00 28.18  ? 229 TYR U OH   1 
ATOM   1576 N N    . PHE A  1 230 ? 110.857 130.006 109.343 1.00 24.37  ? 230 PHE U N    1 
ATOM   1577 C CA   . PHE A  1 230 ? 112.313 129.956 109.411 1.00 22.57  ? 230 PHE U CA   1 
ATOM   1578 C C    . PHE A  1 230 ? 112.807 130.288 110.809 1.00 29.80  ? 230 PHE U C    1 
ATOM   1579 O O    . PHE A  1 230 ? 113.749 129.663 111.307 1.00 30.36  ? 230 PHE U O    1 
ATOM   1580 C CB   . PHE A  1 230 ? 112.930 130.914 108.396 1.00 26.26  ? 230 PHE U CB   1 
ATOM   1581 C CG   . PHE A  1 230 ? 114.378 131.213 108.659 1.00 33.76  ? 230 PHE U CG   1 
ATOM   1582 C CD1  . PHE A  1 230 ? 115.362 130.315 108.293 1.00 30.15  ? 230 PHE U CD1  1 
ATOM   1583 C CD2  . PHE A  1 230 ? 114.754 132.386 109.282 1.00 30.47  ? 230 PHE U CD2  1 
ATOM   1584 C CE1  . PHE A  1 230 ? 116.690 130.585 108.539 1.00 25.46  ? 230 PHE U CE1  1 
ATOM   1585 C CE2  . PHE A  1 230 ? 116.080 132.660 109.530 1.00 25.00  ? 230 PHE U CE2  1 
ATOM   1586 C CZ   . PHE A  1 230 ? 117.048 131.758 109.158 1.00 22.65  ? 230 PHE U CZ   1 
ATOM   1587 N N    . CYS A  1 231 ? 112.197 131.283 111.454 1.00 31.72  ? 231 CYS U N    1 
ATOM   1588 C CA   . CYS A  1 231 ? 112.617 131.644 112.801 1.00 19.34  ? 231 CYS U CA   1 
ATOM   1589 C C    . CYS A  1 231 ? 112.447 130.470 113.750 1.00 23.62  ? 231 CYS U C    1 
ATOM   1590 O O    . CYS A  1 231 ? 113.347 130.159 114.537 1.00 32.90  ? 231 CYS U O    1 
ATOM   1591 C CB   . CYS A  1 231 ? 111.826 132.856 113.294 1.00 16.35  ? 231 CYS U CB   1 
ATOM   1592 S SG   . CYS A  1 231 ? 112.240 134.403 112.466 1.00 38.24  ? 231 CYS U SG   1 
ATOM   1593 N N    . PHE A  1 232 ? 111.301 129.793 113.687 1.00 26.83  ? 232 PHE U N    1 
ATOM   1594 C CA   . PHE A  1 232 ? 111.109 128.647 114.571 1.00 21.99  ? 232 PHE U CA   1 
ATOM   1595 C C    . PHE A  1 232 ? 112.087 127.527 114.251 1.00 17.80  ? 232 PHE U C    1 
ATOM   1596 O O    . PHE A  1 232 ? 112.645 126.907 115.163 1.00 26.37  ? 232 PHE U O    1 
ATOM   1597 C CB   . PHE A  1 232 ? 109.680 128.120 114.496 1.00 20.80  ? 232 PHE U CB   1 
ATOM   1598 C CG   . PHE A  1 232 ? 109.470 126.877 115.309 1.00 29.29  ? 232 PHE U CG   1 
ATOM   1599 C CD1  . PHE A  1 232 ? 109.255 126.956 116.672 1.00 27.02  ? 232 PHE U CD1  1 
ATOM   1600 C CD2  . PHE A  1 232 ? 109.521 125.628 114.718 1.00 28.93  ? 232 PHE U CD2  1 
ATOM   1601 C CE1  . PHE A  1 232 ? 109.078 125.816 117.426 1.00 20.05  ? 232 PHE U CE1  1 
ATOM   1602 C CE2  . PHE A  1 232 ? 109.344 124.485 115.469 1.00 28.83  ? 232 PHE U CE2  1 
ATOM   1603 C CZ   . PHE A  1 232 ? 109.122 124.580 116.824 1.00 22.79  ? 232 PHE U CZ   1 
ATOM   1604 N N    . VAL A  1 233 ? 112.302 127.240 112.967 1.00 22.71  ? 233 VAL U N    1 
ATOM   1605 C CA   . VAL A  1 233 ? 113.179 126.131 112.608 1.00 22.73  ? 233 VAL U CA   1 
ATOM   1606 C C    . VAL A  1 233 ? 114.609 126.405 113.058 1.00 24.47  ? 233 VAL U C    1 
ATOM   1607 O O    . VAL A  1 233 ? 115.302 125.504 113.540 1.00 19.67  ? 233 VAL U O    1 
ATOM   1608 C CB   . VAL A  1 233 ? 113.100 125.852 111.098 1.00 22.34  ? 233 VAL U CB   1 
ATOM   1609 C CG1  . VAL A  1 233 ? 114.176 124.871 110.693 1.00 16.90  ? 233 VAL U CG1  1 
ATOM   1610 C CG2  . VAL A  1 233 ? 111.732 125.312 110.741 1.00 24.10  ? 233 VAL U CG2  1 
ATOM   1611 N N    . ALA A  1 234 ? 115.076 127.644 112.904 1.00 27.16  ? 234 ALA U N    1 
ATOM   1612 C CA   . ALA A  1 234 ? 116.445 127.964 113.294 1.00 19.20  ? 234 ALA U CA   1 
ATOM   1613 C C    . ALA A  1 234 ? 116.593 128.037 114.808 1.00 25.79  ? 234 ALA U C    1 
ATOM   1614 O O    . ALA A  1 234 ? 117.574 127.533 115.365 1.00 29.40  ? 234 ALA U O    1 
ATOM   1615 C CB   . ALA A  1 234 ? 116.878 129.279 112.652 1.00 17.75  ? 234 ALA U CB   1 
ATOM   1616 N N    . PHE A  1 235 ? 115.632 128.662 115.493 1.00 27.82  ? 235 PHE U N    1 
ATOM   1617 C CA   . PHE A  1 235 ? 115.754 128.845 116.935 1.00 17.33  ? 235 PHE U CA   1 
ATOM   1618 C C    . PHE A  1 235 ? 115.747 127.511 117.669 1.00 22.79  ? 235 PHE U C    1 
ATOM   1619 O O    . PHE A  1 235 ? 116.511 127.314 118.621 1.00 24.12  ? 235 PHE U O    1 
ATOM   1620 C CB   . PHE A  1 235 ? 114.630 129.746 117.446 1.00 15.17  ? 235 PHE U CB   1 
ATOM   1621 C CG   . PHE A  1 235 ? 114.710 131.161 116.949 1.00 24.61  ? 235 PHE U CG   1 
ATOM   1622 C CD1  . PHE A  1 235 ? 115.792 131.591 116.205 1.00 26.65  ? 235 PHE U CD1  1 
ATOM   1623 C CD2  . PHE A  1 235 ? 113.703 132.062 117.234 1.00 24.11  ? 235 PHE U CD2  1 
ATOM   1624 C CE1  . PHE A  1 235 ? 115.863 132.890 115.753 1.00 24.93  ? 235 PHE U CE1  1 
ATOM   1625 C CE2  . PHE A  1 235 ? 113.772 133.363 116.784 1.00 17.76  ? 235 PHE U CE2  1 
ATOM   1626 C CZ   . PHE A  1 235 ? 114.852 133.776 116.043 1.00 23.05  ? 235 PHE U CZ   1 
ATOM   1627 N N    . SER A  1 236 ? 114.891 126.582 117.247 1.00 24.23  ? 236 SER U N    1 
ATOM   1628 C CA   . SER A  1 236 ? 114.820 125.281 117.899 1.00 24.09  ? 236 SER U CA   1 
ATOM   1629 C C    . SER A  1 236 ? 116.044 124.420 117.629 1.00 30.44  ? 236 SER U C    1 
ATOM   1630 O O    . SER A  1 236 ? 116.188 123.367 118.257 1.00 28.25  ? 236 SER U O    1 
ATOM   1631 C CB   . SER A  1 236 ? 113.562 124.540 117.453 1.00 21.96  ? 236 SER U CB   1 
ATOM   1632 O OG   . SER A  1 236 ? 113.546 124.370 116.050 1.00 24.48  ? 236 SER U OG   1 
ATOM   1633 N N    . THR A  1 237 ? 116.921 124.838 116.717 1.00 31.51  ? 237 THR U N    1 
ATOM   1634 C CA   . THR A  1 237 ? 118.132 124.111 116.350 1.00 21.39  ? 237 THR U CA   1 
ATOM   1635 C C    . THR A  1 237 ? 117.845 122.884 115.497 1.00 25.58  ? 237 THR U C    1 
ATOM   1636 O O    . THR A  1 237 ? 118.676 121.976 115.421 1.00 34.37  ? 237 THR U O    1 
ATOM   1637 C CB   . THR A  1 237 ? 118.945 123.700 117.582 1.00 25.15  ? 237 THR U CB   1 
ATOM   1638 O OG1  . THR A  1 237 ? 119.350 124.868 118.305 1.00 31.81  ? 237 THR U OG1  1 
ATOM   1639 C CG2  . THR A  1 237 ? 120.173 122.911 117.170 1.00 24.84  ? 237 THR U CG2  1 
ATOM   1640 N N    . ILE A  1 238 ? 116.683 122.828 114.850 1.00 21.19  ? 238 ILE U N    1 
ATOM   1641 C CA   . ILE A  1 238 ? 116.420 121.759 113.893 1.00 20.74  ? 238 ILE U CA   1 
ATOM   1642 C C    . ILE A  1 238 ? 117.196 121.999 112.607 1.00 27.65  ? 238 ILE U C    1 
ATOM   1643 O O    . ILE A  1 238 ? 117.917 121.121 112.120 1.00 39.51  ? 238 ILE U O    1 
ATOM   1644 C CB   . ILE A  1 238 ? 114.910 121.631 113.625 1.00 24.31  ? 238 ILE U CB   1 
ATOM   1645 C CG1  . ILE A  1 238 ? 114.166 121.307 114.918 1.00 25.45  ? 238 ILE U CG1  1 
ATOM   1646 C CG2  . ILE A  1 238 ? 114.647 120.560 112.592 1.00 16.16  ? 238 ILE U CG2  1 
ATOM   1647 C CD1  . ILE A  1 238 ? 112.680 121.159 114.737 1.00 21.09  ? 238 ILE U CD1  1 
ATOM   1648 N N    . GLY A  1 239 ? 117.072 123.199 112.046 1.00 26.36  ? 239 GLY U N    1 
ATOM   1649 C CA   . GLY A  1 239 ? 117.852 123.581 110.888 1.00 14.73  ? 239 GLY U CA   1 
ATOM   1650 C C    . GLY A  1 239 ? 117.700 122.739 109.641 1.00 26.55  ? 239 GLY U C    1 
ATOM   1651 O O    . GLY A  1 239 ? 118.672 122.149 109.163 1.00 38.12  ? 239 GLY U O    1 
ATOM   1652 N N    . PHE A  1 240 ? 116.479 122.626 109.127 1.00 27.31  ? 240 PHE U N    1 
ATOM   1653 C CA   . PHE A  1 240 ? 116.267 121.852 107.909 1.00 20.68  ? 240 PHE U CA   1 
ATOM   1654 C C    . PHE A  1 240 ? 117.185 122.280 106.773 1.00 27.38  ? 240 PHE U C    1 
ATOM   1655 O O    . PHE A  1 240 ? 117.760 121.436 106.079 1.00 34.19  ? 240 PHE U O    1 
ATOM   1656 C CB   . PHE A  1 240 ? 114.806 121.940 107.474 1.00 21.52  ? 240 PHE U CB   1 
ATOM   1657 C CG   . PHE A  1 240 ? 113.871 121.140 108.328 1.00 24.56  ? 240 PHE U CG   1 
ATOM   1658 C CD1  . PHE A  1 240 ? 114.276 119.946 108.886 1.00 27.84  ? 240 PHE U CD1  1 
ATOM   1659 C CD2  . PHE A  1 240 ? 112.585 121.585 108.570 1.00 22.86  ? 240 PHE U CD2  1 
ATOM   1660 C CE1  . PHE A  1 240 ? 113.417 119.210 109.671 1.00 28.66  ? 240 PHE U CE1  1 
ATOM   1661 C CE2  . PHE A  1 240 ? 111.725 120.852 109.354 1.00 26.18  ? 240 PHE U CE2  1 
ATOM   1662 C CZ   . PHE A  1 240 ? 112.141 119.664 109.905 1.00 23.28  ? 240 PHE U CZ   1 
ATOM   1663 N N    . GLY A  1 241 ? 117.339 123.585 106.571 1.00 32.55  ? 241 GLY U N    1 
ATOM   1664 C CA   . GLY A  1 241 ? 118.161 124.104 105.502 1.00 31.26  ? 241 GLY U CA   1 
ATOM   1665 C C    . GLY A  1 241 ? 117.412 124.526 104.260 1.00 35.49  ? 241 GLY U C    1 
ATOM   1666 O O    . GLY A  1 241 ? 118.028 125.098 103.354 1.00 39.69  ? 241 GLY U O    1 
ATOM   1667 N N    . ASP A  1 242 ? 116.106 124.263 104.184 1.00 33.48  ? 242 ASP U N    1 
ATOM   1668 C CA   . ASP A  1 242 ? 115.336 124.703 103.026 1.00 31.17  ? 242 ASP U CA   1 
ATOM   1669 C C    . ASP A  1 242 ? 115.313 126.222 102.928 1.00 38.09  ? 242 ASP U C    1 
ATOM   1670 O O    . ASP A  1 242 ? 115.397 126.783 101.830 1.00 42.30  ? 242 ASP U O    1 
ATOM   1671 C CB   . ASP A  1 242 ? 113.918 124.139 103.093 1.00 31.07  ? 242 ASP U CB   1 
ATOM   1672 C CG   . ASP A  1 242 ? 113.238 124.428 104.412 1.00 44.04  ? 242 ASP U CG   1 
ATOM   1673 O OD1  . ASP A  1 242 ? 113.951 124.656 105.410 1.00 47.36  ? 242 ASP U OD1  1 
ATOM   1674 O OD2  . ASP A  1 242 ? 111.991 124.422 104.453 1.00 44.37  ? 242 ASP U OD2  1 
ATOM   1675 N N    . LEU A  1 243 ? 115.196 126.903 104.063 1.00 39.02  ? 243 LEU U N    1 
ATOM   1676 C CA   . LEU A  1 243 ? 115.261 128.357 104.125 1.00 33.22  ? 243 LEU U CA   1 
ATOM   1677 C C    . LEU A  1 243 ? 116.475 128.752 104.950 1.00 34.79  ? 243 LEU U C    1 
ATOM   1678 O O    . LEU A  1 243 ? 116.549 128.434 106.141 1.00 43.76  ? 243 LEU U O    1 
ATOM   1679 C CB   . LEU A  1 243 ? 113.986 128.946 104.730 1.00 34.78  ? 243 LEU U CB   1 
ATOM   1680 C CG   . LEU A  1 243 ? 112.701 128.796 103.921 1.00 35.11  ? 243 LEU U CG   1 
ATOM   1681 C CD1  . LEU A  1 243 ? 111.542 129.429 104.660 1.00 35.00  ? 243 LEU U CD1  1 
ATOM   1682 C CD2  . LEU A  1 243 ? 112.865 129.418 102.549 1.00 34.56  ? 243 LEU U CD2  1 
ATOM   1683 N N    . VAL A  1 244 ? 117.419 129.441 104.319 1.00 33.15  ? 244 VAL U N    1 
ATOM   1684 C CA   . VAL A  1 244 ? 118.614 129.940 104.985 1.00 31.50  ? 244 VAL U CA   1 
ATOM   1685 C C    . VAL A  1 244 ? 118.726 131.428 104.703 1.00 35.52  ? 244 VAL U C    1 
ATOM   1686 O O    . VAL A  1 244 ? 118.437 131.882 103.590 1.00 35.30  ? 244 VAL U O    1 
ATOM   1687 C CB   . VAL A  1 244 ? 119.883 129.199 104.521 1.00 28.64  ? 244 VAL U CB   1 
ATOM   1688 C CG1  . VAL A  1 244 ? 121.100 129.758 105.226 1.00 28.24  ? 244 VAL U CG1  1 
ATOM   1689 C CG2  . VAL A  1 244 ? 119.750 127.714 104.787 1.00 34.71  ? 244 VAL U CG2  1 
ATOM   1690 N N    . SER A  1 245 ? 119.145 132.185 105.707 1.00 38.72  ? 245 SER U N    1 
ATOM   1691 C CA   . SER A  1 245 ? 119.125 133.636 105.642 1.00 28.60  ? 245 SER U CA   1 
ATOM   1692 C C    . SER A  1 245 ? 120.521 134.201 105.419 1.00 36.01  ? 245 SER U C    1 
ATOM   1693 O O    . SER A  1 245 ? 121.527 133.605 105.808 1.00 41.40  ? 245 SER U O    1 
ATOM   1694 C CB   . SER A  1 245 ? 118.537 134.222 106.924 1.00 28.68  ? 245 SER U CB   1 
ATOM   1695 O OG   . SER A  1 245 ? 118.539 135.635 106.879 1.00 41.73  ? 245 SER U OG   1 
ATOM   1696 N N    . SER A  1 246 ? 120.565 135.373 104.787 1.00 32.79  ? 246 SER U N    1 
ATOM   1697 C CA   . SER A  1 246 ? 121.794 136.152 104.640 1.00 28.84  ? 246 SER U CA   1 
ATOM   1698 C C    . SER A  1 246 ? 122.813 135.453 103.742 1.00 30.01  ? 246 SER U C    1 
ATOM   1699 O O    . SER A  1 246 ? 123.977 135.291 104.105 1.00 38.68  ? 246 SER U O    1 
ATOM   1700 C CB   . SER A  1 246 ? 122.403 136.465 106.007 1.00 33.98  ? 246 SER U CB   1 
ATOM   1701 O OG   . SER A  1 246 ? 123.653 137.113 105.864 1.00 38.55  ? 246 SER U OG   1 
ATOM   1702 N N    . GLN A  1 247 ? 122.367 135.036 102.556 1.00 34.04  ? 247 GLN U N    1 
ATOM   1703 C CA   . GLN A  1 247 ? 123.307 134.601 101.520 1.00 37.06  ? 247 GLN U CA   1 
ATOM   1704 C C    . GLN A  1 247 ? 122.674 134.885 100.157 1.00 35.58  ? 247 GLN U C    1 
ATOM   1705 O O    . GLN A  1 247 ? 121.953 134.050 99.608  1.00 40.80  ? 247 GLN U O    1 
ATOM   1706 C CB   . GLN A  1 247 ? 123.670 133.135 101.682 1.00 36.23  ? 247 GLN U CB   1 
ATOM   1707 C CG   . GLN A  1 247 ? 122.486 132.220 101.857 1.00 31.37  ? 247 GLN U CG   1 
ATOM   1708 C CD   . GLN A  1 247 ? 122.879 130.903 102.477 1.00 36.02  ? 247 GLN U CD   1 
ATOM   1709 O OE1  . GLN A  1 247 ? 123.877 130.815 103.189 1.00 32.91  ? 247 GLN U OE1  1 
ATOM   1710 N NE2  . GLN A  1 247 ? 122.099 129.865 102.208 1.00 42.66  ? 247 GLN U NE2  1 
ATOM   1711 N N    . ASN A  1 248 ? 122.962 136.071 99.620  1.00 35.48  ? 248 ASN U N    1 
ATOM   1712 C CA   . ASN A  1 248 ? 122.508 136.455 98.290  1.00 36.05  ? 248 ASN U CA   1 
ATOM   1713 C C    . ASN A  1 248 ? 123.564 137.269 97.556  1.00 43.34  ? 248 ASN U C    1 
ATOM   1714 O O    . ASN A  1 248 ? 123.228 138.125 96.732  1.00 53.44  ? 248 ASN U O    1 
ATOM   1715 C CB   . ASN A  1 248 ? 121.206 137.254 98.352  1.00 39.45  ? 248 ASN U CB   1 
ATOM   1716 C CG   . ASN A  1 248 ? 119.980 136.371 98.345  1.00 41.36  ? 248 ASN U CG   1 
ATOM   1717 O OD1  . ASN A  1 248 ? 120.033 135.219 97.919  1.00 44.20  ? 248 ASN U OD1  1 
ATOM   1718 N ND2  . ASN A  1 248 ? 118.862 136.913 98.808  1.00 43.05  ? 248 ASN U ND2  1 
ATOM   1719 N N    . ALA A  1 249 ? 124.838 137.012 97.885  1.00 39.41  ? 249 ALA U N    1 
ATOM   1720 C CA   . ALA A  1 249 ? 125.934 137.850 97.342  1.00 41.37  ? 249 ALA U CA   1 
ATOM   1721 C C    . ALA A  1 249 ? 125.580 139.253 97.838  1.00 48.26  ? 249 ALA U C    1 
ATOM   1722 O O    . ALA A  1 249 ? 125.425 139.415 99.064  1.00 54.72  ? 249 ALA U O    1 
ATOM   1723 C CB   . ALA A  1 249 ? 126.003 137.757 95.837  1.00 38.97  ? 249 ALA U CB   1 
ATOM   1724 N N    . HIS A  1 250 ? 125.390 140.199 96.924  1.00 47.45  ? 250 HIS U N    1 
ATOM   1725 C CA   . HIS A  1 250 ? 125.060 141.586 97.338  1.00 46.90  ? 250 HIS U CA   1 
ATOM   1726 C C    . HIS A  1 250 ? 123.811 141.660 98.205  1.00 44.47  ? 250 HIS U C    1 
ATOM   1727 O O    . HIS A  1 250 ? 122.797 141.066 97.840  1.00 41.58  ? 250 HIS U O    1 
ATOM   1728 C CB   . HIS A  1 250 ? 124.935 142.525 96.143  1.00 47.00  ? 250 HIS U CB   1 
ATOM   1729 C CG   . HIS A  1 250 ? 125.076 143.951 96.532  1.00 50.87  ? 250 HIS U CG   1 
ATOM   1730 N ND1  . HIS A  1 250 ? 124.307 144.960 95.998  1.00 53.16  ? 250 HIS U ND1  1 
ATOM   1731 C CD2  . HIS A  1 250 ? 125.892 144.530 97.414  1.00 48.08  ? 250 HIS U CD2  1 
ATOM   1732 C CE1  . HIS A  1 250 ? 124.663 146.111 96.546  1.00 53.21  ? 250 HIS U CE1  1 
ATOM   1733 N NE2  . HIS A  1 250 ? 125.624 145.871 97.409  1.00 51.82  ? 250 HIS U NE2  1 
ATOM   1734 N N    . TYR A  1 251 ? 123.905 142.370 99.337  1.00 43.60  ? 251 TYR U N    1 
ATOM   1735 C CA   . TYR A  1 251 ? 122.766 142.486 100.288 1.00 43.61  ? 251 TYR U CA   1 
ATOM   1736 C C    . TYR A  1 251 ? 122.606 143.943 100.730 1.00 45.07  ? 251 TYR U C    1 
ATOM   1737 O O    . TYR A  1 251 ? 122.352 144.173 101.929 1.00 50.50  ? 251 TYR U O    1 
ATOM   1738 C CB   . TYR A  1 251 ? 123.011 141.610 101.517 1.00 47.43  ? 251 TYR U CB   1 
ATOM   1739 C CG   . TYR A  1 251 ? 122.237 140.318 101.547 1.00 44.10  ? 251 TYR U CG   1 
ATOM   1740 C CD1  . TYR A  1 251 ? 120.868 140.297 101.336 1.00 36.50  ? 251 TYR U CD1  1 
ATOM   1741 C CD2  . TYR A  1 251 ? 122.874 139.115 101.793 1.00 43.24  ? 251 TYR U CD2  1 
ATOM   1742 C CE1  . TYR A  1 251 ? 120.152 139.111 101.366 1.00 41.45  ? 251 TYR U CE1  1 
ATOM   1743 C CE2  . TYR A  1 251 ? 122.173 137.923 101.827 1.00 37.66  ? 251 TYR U CE2  1 
ATOM   1744 C CZ   . TYR A  1 251 ? 120.807 137.919 101.612 1.00 41.72  ? 251 TYR U CZ   1 
ATOM   1745 O OH   . TYR A  1 251 ? 120.115 136.734 101.644 1.00 42.61  ? 251 TYR U OH   1 
ATOM   1746 N N    . GLU A  1 252 ? 122.759 144.891 99.801  1.00 48.81  ? 252 GLU U N    1 
ATOM   1747 C CA   . GLU A  1 252 ? 122.630 146.316 100.115 1.00 50.74  ? 252 GLU U CA   1 
ATOM   1748 C C    . GLU A  1 252 ? 123.676 146.569 101.194 1.00 57.80  ? 252 GLU U C    1 
ATOM   1749 O O    . GLU A  1 252 ? 124.852 146.233 100.974 1.00 60.37  ? 252 GLU U O    1 
ATOM   1750 C CB   . GLU A  1 252 ? 121.184 146.612 100.506 1.00 47.84  ? 252 GLU U CB   1 
ATOM   1751 C CG   . GLU A  1 252 ? 120.885 148.090 100.633 1.00 52.63  ? 252 GLU U CG   1 
ATOM   1752 C CD   . GLU A  1 252 ? 121.132 148.842 99.342  1.00 58.56  ? 252 GLU U CD   1 
ATOM   1753 O OE1  . GLU A  1 252 ? 121.345 148.185 98.302  1.00 58.69  ? 252 GLU U OE1  1 
ATOM   1754 O OE2  . GLU A  1 252 ? 121.115 150.090 99.365  1.00 56.89  ? 252 GLU U OE2  1 
ATOM   1755 N N    . SER A  1 253 ? 123.322 147.145 102.347 1.00 52.14  ? 253 SER U N    1 
ATOM   1756 C CA   . SER A  1 253 ? 124.329 147.405 103.372 1.00 48.18  ? 253 SER U CA   1 
ATOM   1757 C C    . SER A  1 253 ? 125.233 146.216 103.662 1.00 51.74  ? 253 SER U C    1 
ATOM   1758 O O    . SER A  1 253 ? 126.462 146.316 103.575 1.00 56.47  ? 253 SER U O    1 
ATOM   1759 C CB   . SER A  1 253 ? 123.660 147.899 104.652 1.00 45.75  ? 253 SER U CB   1 
ATOM   1760 O OG   . SER A  1 253 ? 122.946 149.099 104.419 1.00 54.13  ? 253 SER U OG   1 
ATOM   1761 N N    . GLN A  1 254 ? 124.641 145.078 104.014 1.00 45.15  ? 254 GLN U N    1 
ATOM   1762 C CA   . GLN A  1 254 ? 125.374 143.824 104.139 1.00 43.00  ? 254 GLN U CA   1 
ATOM   1763 C C    . GLN A  1 254 ? 126.363 143.852 105.295 1.00 45.94  ? 254 GLN U C    1 
ATOM   1764 O O    . GLN A  1 254 ? 126.968 142.827 105.623 1.00 49.53  ? 254 GLN U O    1 
ATOM   1765 C CB   . GLN A  1 254 ? 126.104 143.509 102.834 1.00 36.85  ? 254 GLN U CB   1 
ATOM   1766 C CG   . GLN A  1 254 ? 126.714 142.127 102.791 1.00 41.91  ? 254 GLN U CG   1 
ATOM   1767 C CD   . GLN A  1 254 ? 127.414 141.850 101.482 1.00 45.37  ? 254 GLN U CD   1 
ATOM   1768 O OE1  . GLN A  1 254 ? 127.896 142.764 100.818 1.00 51.51  ? 254 GLN U OE1  1 
ATOM   1769 N NE2  . GLN A  1 254 ? 127.468 140.582 101.098 1.00 45.60  ? 254 GLN U NE2  1 
ATOM   1770 N N    . GLY A  1 255 ? 126.534 145.009 105.924 1.00 44.80  ? 255 GLY U N    1 
ATOM   1771 C CA   . GLY A  1 255 ? 127.397 145.098 107.082 1.00 39.18  ? 255 GLY U CA   1 
ATOM   1772 C C    . GLY A  1 255 ? 126.596 145.005 108.359 1.00 42.73  ? 255 GLY U C    1 
ATOM   1773 O O    . GLY A  1 255 ? 126.911 144.211 109.250 1.00 49.32  ? 255 GLY U O    1 
ATOM   1774 N N    . LEU A  1 256 ? 125.541 145.814 108.451 1.00 36.44  ? 256 LEU U N    1 
ATOM   1775 C CA   . LEU A  1 256 ? 124.639 145.730 109.589 1.00 33.26  ? 256 LEU U CA   1 
ATOM   1776 C C    . LEU A  1 256 ? 123.713 144.530 109.488 1.00 31.94  ? 256 LEU U C    1 
ATOM   1777 O O    . LEU A  1 256 ? 123.274 144.006 110.515 1.00 40.10  ? 256 LEU U O    1 
ATOM   1778 C CB   . LEU A  1 256 ? 123.814 147.010 109.711 1.00 32.90  ? 256 LEU U CB   1 
ATOM   1779 C CG   . LEU A  1 256 ? 124.559 148.304 110.029 1.00 34.26  ? 256 LEU U CG   1 
ATOM   1780 C CD1  . LEU A  1 256 ? 125.411 148.748 108.852 1.00 35.97  ? 256 LEU U CD1  1 
ATOM   1781 C CD2  . LEU A  1 256 ? 123.575 149.389 110.417 1.00 35.49  ? 256 LEU U CD2  1 
ATOM   1782 N N    . TYR A  1 257 ? 123.398 144.088 108.270 1.00 27.46  ? 257 TYR U N    1 
ATOM   1783 C CA   . TYR A  1 257 ? 122.471 142.974 108.115 1.00 27.66  ? 257 TYR U CA   1 
ATOM   1784 C C    . TYR A  1 257 ? 123.029 141.700 108.736 1.00 33.61  ? 257 TYR U C    1 
ATOM   1785 O O    . TYR A  1 257 ? 122.307 140.969 109.421 1.00 34.32  ? 257 TYR U O    1 
ATOM   1786 C CB   . TYR A  1 257 ? 122.151 142.758 106.638 1.00 29.20  ? 257 TYR U CB   1 
ATOM   1787 C CG   . TYR A  1 257 ? 121.125 141.680 106.400 1.00 34.25  ? 257 TYR U CG   1 
ATOM   1788 C CD1  . TYR A  1 257 ? 119.772 141.943 106.535 1.00 39.15  ? 257 TYR U CD1  1 
ATOM   1789 C CD2  . TYR A  1 257 ? 121.508 140.399 106.048 1.00 31.81  ? 257 TYR U CD2  1 
ATOM   1790 C CE1  . TYR A  1 257 ? 118.832 140.961 106.324 1.00 36.03  ? 257 TYR U CE1  1 
ATOM   1791 C CE2  . TYR A  1 257 ? 120.574 139.410 105.836 1.00 29.73  ? 257 TYR U CE2  1 
ATOM   1792 C CZ   . TYR A  1 257 ? 119.239 139.697 105.975 1.00 34.38  ? 257 TYR U CZ   1 
ATOM   1793 O OH   . TYR A  1 257 ? 118.304 138.712 105.762 1.00 36.82  ? 257 TYR U OH   1 
ATOM   1794 N N    . ARG A  1 258 ? 124.312 141.418 108.512 1.00 32.49  ? 258 ARG U N    1 
ATOM   1795 C CA   . ARG A  1 258 ? 124.911 140.219 109.087 1.00 26.54  ? 258 ARG U CA   1 
ATOM   1796 C C    . ARG A  1 258 ? 124.960 140.296 110.608 1.00 33.72  ? 258 ARG U C    1 
ATOM   1797 O O    . ARG A  1 258 ? 124.685 139.306 111.295 1.00 40.30  ? 258 ARG U O    1 
ATOM   1798 C CB   . ARG A  1 258 ? 126.306 140.007 108.506 1.00 29.14  ? 258 ARG U CB   1 
ATOM   1799 C CG   . ARG A  1 258 ? 126.297 139.713 107.019 1.00 33.79  ? 258 ARG U CG   1 
ATOM   1800 C CD   . ARG A  1 258 ? 127.697 139.606 106.454 1.00 33.93  ? 258 ARG U CD   1 
ATOM   1801 N NE   . ARG A  1 258 ? 127.678 139.183 105.060 1.00 35.85  ? 258 ARG U NE   1 
ATOM   1802 C CZ   . ARG A  1 258 ? 128.752 139.098 104.288 1.00 35.58  ? 258 ARG U CZ   1 
ATOM   1803 N NH1  . ARG A  1 258 ? 129.953 139.418 104.740 1.00 39.81  ? 258 ARG U NH1  1 
ATOM   1804 N NH2  . ARG A  1 258 ? 128.617 138.684 103.033 1.00 31.57  ? 258 ARG U NH2  1 
ATOM   1805 N N    . PHE A  1 259 ? 125.307 141.463 111.151 1.00 33.64  ? 259 PHE U N    1 
ATOM   1806 C CA   . PHE A  1 259 ? 125.322 141.628 112.600 1.00 31.59  ? 259 PHE U CA   1 
ATOM   1807 C C    . PHE A  1 259 ? 123.931 141.422 113.189 1.00 32.83  ? 259 PHE U C    1 
ATOM   1808 O O    . PHE A  1 259 ? 123.774 140.743 114.213 1.00 35.80  ? 259 PHE U O    1 
ATOM   1809 C CB   . PHE A  1 259 ? 125.865 143.014 112.947 1.00 27.52  ? 259 PHE U CB   1 
ATOM   1810 C CG   . PHE A  1 259 ? 125.766 143.359 114.401 1.00 35.62  ? 259 PHE U CG   1 
ATOM   1811 C CD1  . PHE A  1 259 ? 126.591 142.752 115.327 1.00 34.47  ? 259 PHE U CD1  1 
ATOM   1812 C CD2  . PHE A  1 259 ? 124.861 144.306 114.838 1.00 33.15  ? 259 PHE U CD2  1 
ATOM   1813 C CE1  . PHE A  1 259 ? 126.505 143.073 116.662 1.00 33.29  ? 259 PHE U CE1  1 
ATOM   1814 C CE2  . PHE A  1 259 ? 124.772 144.631 116.172 1.00 33.12  ? 259 PHE U CE2  1 
ATOM   1815 C CZ   . PHE A  1 259 ? 125.594 144.014 117.086 1.00 31.31  ? 259 PHE U CZ   1 
ATOM   1816 N N    . ALA A  1 260 ? 122.910 141.993 112.550 1.00 30.49  ? 260 ALA U N    1 
ATOM   1817 C CA   . ALA A  1 260 ? 121.544 141.823 113.030 1.00 28.52  ? 260 ALA U CA   1 
ATOM   1818 C C    . ALA A  1 260 ? 121.115 140.365 112.962 1.00 31.39  ? 260 ALA U C    1 
ATOM   1819 O O    . ALA A  1 260 ? 120.461 139.860 113.879 1.00 40.65  ? 260 ALA U O    1 
ATOM   1820 C CB   . ALA A  1 260 ? 120.593 142.702 112.220 1.00 30.55  ? 260 ALA U CB   1 
ATOM   1821 N N    . ASN A  1 261 ? 121.467 139.674 111.877 1.00 33.60  ? 261 ASN U N    1 
ATOM   1822 C CA   . ASN A  1 261 ? 121.133 138.260 111.766 1.00 36.03  ? 261 ASN U CA   1 
ATOM   1823 C C    . ASN A  1 261 ? 121.793 137.455 112.877 1.00 32.30  ? 261 ASN U C    1 
ATOM   1824 O O    . ASN A  1 261 ? 121.154 136.602 113.507 1.00 36.65  ? 261 ASN U O    1 
ATOM   1825 C CB   . ASN A  1 261 ? 121.557 137.738 110.394 1.00 34.87  ? 261 ASN U CB   1 
ATOM   1826 C CG   . ASN A  1 261 ? 121.115 136.318 110.149 1.00 37.97  ? 261 ASN U CG   1 
ATOM   1827 O OD1  . ASN A  1 261 ? 120.818 135.578 111.084 1.00 46.53  ? 261 ASN U OD1  1 
ATOM   1828 N ND2  . ASN A  1 261 ? 121.064 135.925 108.884 1.00 30.91  ? 261 ASN U ND2  1 
ATOM   1829 N N    . PHE A  1 262 ? 123.071 137.729 113.144 1.00 25.45  ? 262 PHE U N    1 
ATOM   1830 C CA   . PHE A  1 262 ? 123.777 137.042 114.219 1.00 34.45  ? 262 PHE U CA   1 
ATOM   1831 C C    . PHE A  1 262 ? 123.078 137.261 115.556 1.00 37.84  ? 262 PHE U C    1 
ATOM   1832 O O    . PHE A  1 262 ? 122.814 136.307 116.300 1.00 36.19  ? 262 PHE U O    1 
ATOM   1833 C CB   . PHE A  1 262 ? 125.225 137.533 114.267 1.00 30.88  ? 262 PHE U CB   1 
ATOM   1834 C CG   . PHE A  1 262 ? 126.019 136.998 115.423 1.00 35.40  ? 262 PHE U CG   1 
ATOM   1835 C CD1  . PHE A  1 262 ? 126.658 135.777 115.334 1.00 35.00  ? 262 PHE U CD1  1 
ATOM   1836 C CD2  . PHE A  1 262 ? 126.150 137.731 116.587 1.00 34.55  ? 262 PHE U CD2  1 
ATOM   1837 C CE1  . PHE A  1 262 ? 127.394 135.287 116.392 1.00 35.87  ? 262 PHE U CE1  1 
ATOM   1838 C CE2  . PHE A  1 262 ? 126.888 137.246 117.646 1.00 30.14  ? 262 PHE U CE2  1 
ATOM   1839 C CZ   . PHE A  1 262 ? 127.510 136.024 117.548 1.00 31.04  ? 262 PHE U CZ   1 
ATOM   1840 N N    . VAL A  1 263 ? 122.755 138.517 115.866 1.00 36.18  ? 263 VAL U N    1 
ATOM   1841 C CA   . VAL A  1 263 ? 122.140 138.831 117.154 1.00 28.90  ? 263 VAL U CA   1 
ATOM   1842 C C    . VAL A  1 263 ? 120.785 138.147 117.283 1.00 30.61  ? 263 VAL U C    1 
ATOM   1843 O O    . VAL A  1 263 ? 120.461 137.556 118.323 1.00 42.00  ? 263 VAL U O    1 
ATOM   1844 C CB   . VAL A  1 263 ? 122.019 140.354 117.330 1.00 30.61  ? 263 VAL U CB   1 
ATOM   1845 C CG1  . VAL A  1 263 ? 121.191 140.677 118.553 1.00 35.44  ? 263 VAL U CG1  1 
ATOM   1846 C CG2  . VAL A  1 263 ? 123.393 140.977 117.438 1.00 33.56  ? 263 VAL U CG2  1 
ATOM   1847 N N    . PHE A  1 264 ? 119.966 138.227 116.233 1.00 27.62  ? 264 PHE U N    1 
ATOM   1848 C CA   . PHE A  1 264 ? 118.633 137.640 116.291 1.00 25.82  ? 264 PHE U CA   1 
ATOM   1849 C C    . PHE A  1 264 ? 118.707 136.134 116.488 1.00 24.42  ? 264 PHE U C    1 
ATOM   1850 O O    . PHE A  1 264 ? 117.984 135.569 117.318 1.00 32.74  ? 264 PHE U O    1 
ATOM   1851 C CB   . PHE A  1 264 ? 117.854 137.980 115.024 1.00 26.97  ? 264 PHE U CB   1 
ATOM   1852 C CG   . PHE A  1 264 ? 117.250 139.351 115.035 1.00 32.70  ? 264 PHE U CG   1 
ATOM   1853 C CD1  . PHE A  1 264 ? 116.669 139.854 116.183 1.00 33.71  ? 264 PHE U CD1  1 
ATOM   1854 C CD2  . PHE A  1 264 ? 117.266 140.137 113.900 1.00 28.78  ? 264 PHE U CD2  1 
ATOM   1855 C CE1  . PHE A  1 264 ? 116.113 141.114 116.196 1.00 32.63  ? 264 PHE U CE1  1 
ATOM   1856 C CE2  . PHE A  1 264 ? 116.714 141.399 113.910 1.00 29.61  ? 264 PHE U CE2  1 
ATOM   1857 C CZ   . PHE A  1 264 ? 116.136 141.887 115.058 1.00 34.95  ? 264 PHE U CZ   1 
ATOM   1858 N N    . ILE A  1 265 ? 119.579 135.461 115.735 1.00 27.58  ? 265 ILE U N    1 
ATOM   1859 C CA   . ILE A  1 265 ? 119.681 134.012 115.868 1.00 28.73  ? 265 ILE U CA   1 
ATOM   1860 C C    . ILE A  1 265 ? 120.165 133.639 117.263 1.00 31.11  ? 265 ILE U C    1 
ATOM   1861 O O    . ILE A  1 265 ? 119.651 132.697 117.879 1.00 35.91  ? 265 ILE U O    1 
ATOM   1862 C CB   . ILE A  1 265 ? 120.591 133.430 114.774 1.00 30.59  ? 265 ILE U CB   1 
ATOM   1863 C CG1  . ILE A  1 265 ? 119.951 133.629 113.400 1.00 26.43  ? 265 ILE U CG1  1 
ATOM   1864 C CG2  . ILE A  1 265 ? 120.838 131.957 115.025 1.00 28.36  ? 265 ILE U CG2  1 
ATOM   1865 C CD1  . ILE A  1 265 ? 120.657 132.895 112.291 1.00 25.55  ? 265 ILE U CD1  1 
ATOM   1866 N N    . LEU A  1 266 ? 121.154 134.367 117.786 1.00 31.53  ? 266 LEU U N    1 
ATOM   1867 C CA   . LEU A  1 266 ? 121.653 134.073 119.125 1.00 27.00  ? 266 LEU U CA   1 
ATOM   1868 C C    . LEU A  1 266 ? 120.544 134.188 120.166 1.00 31.96  ? 266 LEU U C    1 
ATOM   1869 O O    . LEU A  1 266 ? 120.329 133.273 120.976 1.00 33.24  ? 266 LEU U O    1 
ATOM   1870 C CB   . LEU A  1 266 ? 122.808 135.013 119.461 1.00 28.68  ? 266 LEU U CB   1 
ATOM   1871 C CG   . LEU A  1 266 ? 123.411 134.925 120.859 1.00 33.01  ? 266 LEU U CG   1 
ATOM   1872 C CD1  . LEU A  1 266 ? 124.067 133.578 121.069 1.00 36.93  ? 266 LEU U CD1  1 
ATOM   1873 C CD2  . LEU A  1 266 ? 124.407 136.046 121.070 1.00 26.98  ? 266 LEU U CD2  1 
ATOM   1874 N N    . MET A  1 267 ? 119.823 135.313 120.157 1.00 30.13  ? 267 MET U N    1 
ATOM   1875 C CA   . MET A  1 267 ? 118.782 135.518 121.158 1.00 29.28  ? 267 MET U CA   1 
ATOM   1876 C C    . MET A  1 267 ? 117.679 134.476 121.029 1.00 34.34  ? 267 MET U C    1 
ATOM   1877 O O    . MET A  1 267 ? 117.198 133.939 122.037 1.00 44.49  ? 267 MET U O    1 
ATOM   1878 C CB   . MET A  1 267 ? 118.206 136.927 121.041 1.00 30.05  ? 267 MET U CB   1 
ATOM   1879 C CG   . MET A  1 267 ? 119.214 138.025 121.303 1.00 34.11  ? 267 MET U CG   1 
ATOM   1880 S SD   . MET A  1 267 ? 118.439 139.629 121.563 1.00 59.83  ? 267 MET U SD   1 
ATOM   1881 C CE   . MET A  1 267 ? 117.514 139.808 120.043 1.00 40.03  ? 267 MET U CE   1 
ATOM   1882 N N    . GLY A  1 268 ? 117.259 134.179 119.799 1.00 27.15  ? 268 GLY U N    1 
ATOM   1883 C CA   . GLY A  1 268 ? 116.221 133.182 119.613 1.00 23.27  ? 268 GLY U CA   1 
ATOM   1884 C C    . GLY A  1 268 ? 116.639 131.812 120.106 1.00 22.51  ? 268 GLY U C    1 
ATOM   1885 O O    . GLY A  1 268 ? 115.856 131.108 120.749 1.00 27.32  ? 268 GLY U O    1 
ATOM   1886 N N    . VAL A  1 269 ? 117.877 131.413 119.811 1.00 25.89  ? 269 VAL U N    1 
ATOM   1887 C CA   . VAL A  1 269 ? 118.354 130.110 120.263 1.00 27.69  ? 269 VAL U CA   1 
ATOM   1888 C C    . VAL A  1 269 ? 118.345 130.047 121.783 1.00 33.47  ? 269 VAL U C    1 
ATOM   1889 O O    . VAL A  1 269 ? 117.886 129.064 122.377 1.00 43.49  ? 269 VAL U O    1 
ATOM   1890 C CB   . VAL A  1 269 ? 119.752 129.818 119.693 1.00 32.53  ? 269 VAL U CB   1 
ATOM   1891 C CG1  . VAL A  1 269 ? 120.272 128.507 120.240 1.00 31.42  ? 269 VAL U CG1  1 
ATOM   1892 C CG2  . VAL A  1 269 ? 119.706 129.779 118.181 1.00 33.56  ? 269 VAL U CG2  1 
ATOM   1893 N N    . CYS A  1 270 ? 118.846 131.098 122.438 1.00 37.75  ? 270 CYS U N    1 
ATOM   1894 C CA   . CYS A  1 270 ? 118.855 131.098 123.899 1.00 33.16  ? 270 CYS U CA   1 
ATOM   1895 C C    . CYS A  1 270 ? 117.444 130.961 124.457 1.00 33.05  ? 270 CYS U C    1 
ATOM   1896 O O    . CYS A  1 270 ? 117.179 130.118 125.331 1.00 42.27  ? 270 CYS U O    1 
ATOM   1897 C CB   . CYS A  1 270 ? 119.519 132.370 124.421 1.00 30.30  ? 270 CYS U CB   1 
ATOM   1898 S SG   . CYS A  1 270 ? 121.299 132.446 124.162 1.00 52.44  ? 270 CYS U SG   1 
ATOM   1899 N N    . CYS A  1 271 ? 116.515 131.783 123.959 1.00 26.24  ? 271 CYS U N    1 
ATOM   1900 C CA   . CYS A  1 271 ? 115.163 131.768 124.503 1.00 27.48  ? 271 CYS U CA   1 
ATOM   1901 C C    . CYS A  1 271 ? 114.490 130.418 124.287 1.00 33.18  ? 271 CYS U C    1 
ATOM   1902 O O    . CYS A  1 271 ? 113.846 129.886 125.200 1.00 39.58  ? 271 CYS U O    1 
ATOM   1903 C CB   . CYS A  1 271 ? 114.334 132.889 123.880 1.00 30.99  ? 271 CYS U CB   1 
ATOM   1904 S SG   . CYS A  1 271 ? 114.870 134.545 124.349 1.00 57.96  ? 271 CYS U SG   1 
ATOM   1905 N N    . ILE A  1 272 ? 114.632 129.840 123.093 1.00 30.03  ? 272 ILE U N    1 
ATOM   1906 C CA   . ILE A  1 272 ? 113.962 128.575 122.813 1.00 30.38  ? 272 ILE U CA   1 
ATOM   1907 C C    . ILE A  1 272 ? 114.578 127.444 123.627 1.00 33.66  ? 272 ILE U C    1 
ATOM   1908 O O    . ILE A  1 272 ? 113.869 126.544 124.089 1.00 36.62  ? 272 ILE U O    1 
ATOM   1909 C CB   . ILE A  1 272 ? 113.985 128.272 121.307 1.00 32.79  ? 272 ILE U CB   1 
ATOM   1910 C CG1  . ILE A  1 272 ? 113.113 129.278 120.559 1.00 29.52  ? 272 ILE U CG1  1 
ATOM   1911 C CG2  . ILE A  1 272 ? 113.491 126.868 121.051 1.00 26.74  ? 272 ILE U CG2  1 
ATOM   1912 C CD1  . ILE A  1 272 ? 111.672 129.263 120.991 1.00 27.59  ? 272 ILE U CD1  1 
ATOM   1913 N N    . TYR A  1 273 ? 115.899 127.459 123.812 1.00 33.64  ? 273 TYR U N    1 
ATOM   1914 C CA   . TYR A  1 273 ? 116.534 126.442 124.644 1.00 31.65  ? 273 TYR U CA   1 
ATOM   1915 C C    . TYR A  1 273 ? 115.996 126.496 126.070 1.00 36.63  ? 273 TYR U C    1 
ATOM   1916 O O    . TYR A  1 273 ? 115.629 125.464 126.656 1.00 39.18  ? 273 TYR U O    1 
ATOM   1917 C CB   . TYR A  1 273 ? 118.048 126.645 124.619 1.00 30.67  ? 273 TYR U CB   1 
ATOM   1918 C CG   . TYR A  1 273 ? 118.850 125.595 125.347 1.00 41.88  ? 273 TYR U CG   1 
ATOM   1919 C CD1  . TYR A  1 273 ? 119.161 125.741 126.691 1.00 41.43  ? 273 TYR U CD1  1 
ATOM   1920 C CD2  . TYR A  1 273 ? 119.315 124.469 124.686 1.00 39.31  ? 273 TYR U CD2  1 
ATOM   1921 C CE1  . TYR A  1 273 ? 119.899 124.789 127.358 1.00 37.34  ? 273 TYR U CE1  1 
ATOM   1922 C CE2  . TYR A  1 273 ? 120.054 123.512 125.344 1.00 40.08  ? 273 TYR U CE2  1 
ATOM   1923 C CZ   . TYR A  1 273 ? 120.343 123.676 126.680 1.00 45.77  ? 273 TYR U CZ   1 
ATOM   1924 O OH   . TYR A  1 273 ? 121.080 122.723 127.342 1.00 49.98  ? 273 TYR U OH   1 
ATOM   1925 N N    . SER A  1 274 ? 115.921 127.702 126.639 1.00 33.18  ? 274 SER U N    1 
ATOM   1926 C CA   . SER A  1 274 ? 115.388 127.831 127.990 1.00 31.95  ? 274 SER U CA   1 
ATOM   1927 C C    . SER A  1 274 ? 113.936 127.370 128.058 1.00 33.97  ? 274 SER U C    1 
ATOM   1928 O O    . SER A  1 274 ? 113.532 126.684 129.009 1.00 42.97  ? 274 SER U O    1 
ATOM   1929 C CB   . SER A  1 274 ? 115.518 129.276 128.463 1.00 36.30  ? 274 SER U CB   1 
ATOM   1930 O OG   . SER A  1 274 ? 116.861 129.715 128.365 1.00 37.90  ? 274 SER U OG   1 
ATOM   1931 N N    . LEU A  1 275 ? 113.134 127.740 127.057 1.00 30.34  ? 275 LEU U N    1 
ATOM   1932 C CA   . LEU A  1 275 ? 111.735 127.333 127.045 1.00 33.18  ? 275 LEU U CA   1 
ATOM   1933 C C    . LEU A  1 275 ? 111.604 125.817 127.003 1.00 35.96  ? 275 LEU U C    1 
ATOM   1934 O O    . LEU A  1 275 ? 110.766 125.238 127.705 1.00 36.83  ? 275 LEU U O    1 
ATOM   1935 C CB   . LEU A  1 275 ? 111.019 127.968 125.855 1.00 29.46  ? 275 LEU U CB   1 
ATOM   1936 C CG   . LEU A  1 275 ? 109.522 127.700 125.738 1.00 32.53  ? 275 LEU U CG   1 
ATOM   1937 C CD1  . LEU A  1 275 ? 108.799 128.220 126.962 1.00 31.46  ? 275 LEU U CD1  1 
ATOM   1938 C CD2  . LEU A  1 275 ? 108.971 128.337 124.478 1.00 33.34  ? 275 LEU U CD2  1 
ATOM   1939 N N    . PHE A  1 276 ? 112.420 125.156 126.181 1.00 33.72  ? 276 PHE U N    1 
ATOM   1940 C CA   . PHE A  1 276 ? 112.365 123.701 126.108 1.00 23.36  ? 276 PHE U CA   1 
ATOM   1941 C C    . PHE A  1 276 ? 112.719 123.069 127.447 1.00 25.68  ? 276 PHE U C    1 
ATOM   1942 O O    . PHE A  1 276 ? 112.065 122.113 127.879 1.00 31.01  ? 276 PHE U O    1 
ATOM   1943 C CB   . PHE A  1 276 ? 113.292 123.188 125.008 1.00 23.56  ? 276 PHE U CB   1 
ATOM   1944 C CG   . PHE A  1 276 ? 112.727 123.331 123.627 1.00 31.77  ? 276 PHE U CG   1 
ATOM   1945 C CD1  . PHE A  1 276 ? 111.449 123.820 123.435 1.00 31.35  ? 276 PHE U CD1  1 
ATOM   1946 C CD2  . PHE A  1 276 ? 113.467 122.960 122.520 1.00 27.95  ? 276 PHE U CD2  1 
ATOM   1947 C CE1  . PHE A  1 276 ? 110.925 123.947 122.168 1.00 24.95  ? 276 PHE U CE1  1 
ATOM   1948 C CE2  . PHE A  1 276 ? 112.946 123.085 121.251 1.00 26.04  ? 276 PHE U CE2  1 
ATOM   1949 C CZ   . PHE A  1 276 ? 111.674 123.579 121.076 1.00 22.27  ? 276 PHE U CZ   1 
ATOM   1950 N N    . ASN A  1 277 ? 113.746 123.587 128.122 1.00 31.70  ? 277 ASN U N    1 
ATOM   1951 C CA   . ASN A  1 277 ? 114.097 123.023 129.425 1.00 26.26  ? 277 ASN U CA   1 
ATOM   1952 C C    . ASN A  1 277 ? 112.956 123.179 130.429 1.00 31.12  ? 277 ASN U C    1 
ATOM   1953 O O    . ASN A  1 277 ? 112.620 122.235 131.162 1.00 41.23  ? 277 ASN U O    1 
ATOM   1954 C CB   . ASN A  1 277 ? 115.373 123.671 129.953 1.00 27.73  ? 277 ASN U CB   1 
ATOM   1955 C CG   . ASN A  1 277 ? 116.606 123.207 129.212 1.00 36.76  ? 277 ASN U CG   1 
ATOM   1956 O OD1  . ASN A  1 277 ? 116.515 122.670 128.110 1.00 30.73  ? 277 ASN U OD1  1 
ATOM   1957 N ND2  . ASN A  1 277 ? 117.769 123.409 129.816 1.00 39.65  ? 277 ASN U ND2  1 
ATOM   1958 N N    . VAL A  1 278 ? 112.343 124.363 130.474 1.00 31.00  ? 278 VAL U N    1 
ATOM   1959 C CA   . VAL A  1 278 ? 111.250 124.578 131.422 1.00 29.92  ? 278 VAL U CA   1 
ATOM   1960 C C    . VAL A  1 278 ? 110.079 123.653 131.110 1.00 34.50  ? 278 VAL U C    1 
ATOM   1961 O O    . VAL A  1 278 ? 109.458 123.074 132.017 1.00 39.75  ? 278 VAL U O    1 
ATOM   1962 C CB   . VAL A  1 278 ? 110.825 126.055 131.422 1.00 35.59  ? 278 VAL U CB   1 
ATOM   1963 C CG1  . VAL A  1 278 ? 109.613 126.249 132.306 1.00 37.34  ? 278 VAL U CG1  1 
ATOM   1964 C CG2  . VAL A  1 278 ? 111.971 126.926 131.894 1.00 32.90  ? 278 VAL U CG2  1 
ATOM   1965 N N    . ILE A  1 279 ? 109.750 123.500 129.826 1.00 33.11  ? 279 ILE U N    1 
ATOM   1966 C CA   . ILE A  1 279 ? 108.643 122.626 129.455 1.00 30.18  ? 279 ILE U CA   1 
ATOM   1967 C C    . ILE A  1 279 ? 108.957 121.184 129.827 1.00 33.54  ? 279 ILE U C    1 
ATOM   1968 O O    . ILE A  1 279 ? 108.065 120.423 130.216 1.00 39.82  ? 279 ILE U O    1 
ATOM   1969 C CB   . ILE A  1 279 ? 108.320 122.770 127.959 1.00 30.85  ? 279 ILE U CB   1 
ATOM   1970 C CG1  . ILE A  1 279 ? 107.775 124.167 127.670 1.00 29.39  ? 279 ILE U CG1  1 
ATOM   1971 C CG2  . ILE A  1 279 ? 107.325 121.714 127.533 1.00 31.91  ? 279 ILE U CG2  1 
ATOM   1972 C CD1  . ILE A  1 279 ? 107.380 124.378 126.231 1.00 29.90  ? 279 ILE U CD1  1 
ATOM   1973 N N    . SER A  1 280 ? 110.223 120.780 129.707 1.00 31.90  ? 280 SER U N    1 
ATOM   1974 C CA   . SER A  1 280 ? 110.595 119.431 130.124 1.00 26.33  ? 280 SER U CA   1 
ATOM   1975 C C    . SER A  1 280 ? 110.372 119.240 131.617 1.00 28.85  ? 280 SER U C    1 
ATOM   1976 O O    . SER A  1 280 ? 109.892 118.187 132.054 1.00 35.94  ? 280 SER U O    1 
ATOM   1977 C CB   . SER A  1 280 ? 112.049 119.147 129.757 1.00 26.44  ? 280 SER U CB   1 
ATOM   1978 O OG   . SER A  1 280 ? 112.930 119.944 130.525 1.00 37.64  ? 280 SER U OG   1 
ATOM   1979 N N    . ILE A  1 281 ? 110.719 120.247 132.420 1.00 34.01  ? 281 ILE U N    1 
ATOM   1980 C CA   . ILE A  1 281 ? 110.465 120.144 133.858 1.00 36.49  ? 281 ILE U CA   1 
ATOM   1981 C C    . ILE A  1 281 ? 108.972 119.987 134.128 1.00 39.12  ? 281 ILE U C    1 
ATOM   1982 O O    . ILE A  1 281 ? 108.549 119.158 134.952 1.00 45.06  ? 281 ILE U O    1 
ATOM   1983 C CB   . ILE A  1 281 ? 111.047 121.360 134.595 1.00 34.52  ? 281 ILE U CB   1 
ATOM   1984 C CG1  . ILE A  1 281 ? 112.572 121.339 134.535 1.00 33.30  ? 281 ILE U CG1  1 
ATOM   1985 C CG2  . ILE A  1 281 ? 110.571 121.379 136.034 1.00 36.29  ? 281 ILE U CG2  1 
ATOM   1986 C CD1  . ILE A  1 281 ? 113.220 122.485 135.267 1.00 38.51  ? 281 ILE U CD1  1 
ATOM   1987 N N    . LEU A  1 282 ? 108.148 120.783 133.444 1.00 34.37  ? 282 LEU U N    1 
ATOM   1988 C CA   . LEU A  1 282 ? 106.704 120.671 133.641 1.00 34.27  ? 282 LEU U CA   1 
ATOM   1989 C C    . LEU A  1 282 ? 106.194 119.289 133.243 1.00 35.90  ? 282 LEU U C    1 
ATOM   1990 O O    . LEU A  1 282 ? 105.334 118.713 133.923 1.00 40.05  ? 282 LEU U O    1 
ATOM   1991 C CB   . LEU A  1 282 ? 105.977 121.758 132.855 1.00 37.89  ? 282 LEU U CB   1 
ATOM   1992 C CG   . LEU A  1 282 ? 106.039 123.163 133.449 1.00 38.13  ? 282 LEU U CG   1 
ATOM   1993 C CD1  . LEU A  1 282 ? 105.254 124.128 132.590 1.00 38.26  ? 282 LEU U CD1  1 
ATOM   1994 C CD2  . LEU A  1 282 ? 105.510 123.159 134.867 1.00 34.87  ? 282 LEU U CD2  1 
ATOM   1995 N N    . ILE A  1 283 ? 106.706 118.745 132.139 1.00 34.30  ? 283 ILE U N    1 
ATOM   1996 C CA   . ILE A  1 283 ? 106.285 117.416 131.703 1.00 31.79  ? 283 ILE U CA   1 
ATOM   1997 C C    . ILE A  1 283 ? 106.671 116.370 132.737 1.00 33.56  ? 283 ILE U C    1 
ATOM   1998 O O    . ILE A  1 283 ? 105.923 115.417 132.986 1.00 36.65  ? 283 ILE U O    1 
ATOM   1999 C CB   . ILE A  1 283 ? 106.877 117.089 130.321 1.00 30.50  ? 283 ILE U CB   1 
ATOM   2000 C CG1  . ILE A  1 283 ? 106.273 117.997 129.251 1.00 34.46  ? 283 ILE U CG1  1 
ATOM   2001 C CG2  . ILE A  1 283 ? 106.638 115.637 129.974 1.00 29.01  ? 283 ILE U CG2  1 
ATOM   2002 C CD1  . ILE A  1 283 ? 106.786 117.716 127.864 1.00 31.06  ? 283 ILE U CD1  1 
ATOM   2003 N N    . LYS A  1 284 ? 107.852 116.513 133.339 1.00 34.26  ? 284 LYS U N    1 
ATOM   2004 C CA   . LYS A  1 284 ? 108.258 115.578 134.384 1.00 32.78  ? 284 LYS U CA   1 
ATOM   2005 C C    . LYS A  1 284 ? 107.300 115.628 135.567 1.00 33.16  ? 284 LYS U C    1 
ATOM   2006 O O    . LYS A  1 284 ? 106.912 114.587 136.114 1.00 35.89  ? 284 LYS U O    1 
ATOM   2007 C CB   . LYS A  1 284 ? 109.683 115.885 134.833 1.00 31.24  ? 284 LYS U CB   1 
ATOM   2008 C CG   . LYS A  1 284 ? 110.207 114.969 135.916 1.00 30.46  ? 284 LYS U CG   1 
ATOM   2009 C CD   . LYS A  1 284 ? 111.604 115.385 136.336 1.00 35.64  ? 284 LYS U CD   1 
ATOM   2010 C CE   . LYS A  1 284 ? 112.150 114.477 137.416 1.00 37.02  ? 284 LYS U CE   1 
ATOM   2011 N NZ   . LYS A  1 284 ? 112.273 113.076 136.939 1.00 38.79  ? 284 LYS U NZ   1 
ATOM   2012 N N    . GLN A  1 285 ? 106.907 116.835 135.979 1.00 40.07  ? 285 GLN U N    1 
ATOM   2013 C CA   . GLN A  1 285 ? 105.938 116.943 137.068 1.00 38.02  ? 285 GLN U CA   1 
ATOM   2014 C C    . GLN A  1 285 ? 104.616 116.282 136.696 1.00 40.15  ? 285 GLN U C    1 
ATOM   2015 O O    . GLN A  1 285 ? 103.992 115.601 137.523 1.00 40.31  ? 285 GLN U O    1 
ATOM   2016 C CB   . GLN A  1 285 ? 105.721 118.406 137.443 1.00 39.53  ? 285 GLN U CB   1 
ATOM   2017 C CG   . GLN A  1 285 ? 106.920 119.058 138.099 1.00 45.74  ? 285 GLN U CG   1 
ATOM   2018 C CD   . GLN A  1 285 ? 106.620 120.458 138.586 1.00 53.13  ? 285 GLN U CD   1 
ATOM   2019 O OE1  . GLN A  1 285 ? 105.485 120.927 138.500 1.00 53.38  ? 285 GLN U OE1  1 
ATOM   2020 N NE2  . GLN A  1 285 ? 107.637 121.137 139.101 1.00 50.85  ? 285 GLN U NE2  1 
ATOM   2021 N N    . SER A  1 286 ? 104.169 116.474 135.455 1.00 42.63  ? 286 SER U N    1 
ATOM   2022 C CA   . SER A  1 286 ? 102.927 115.847 135.015 1.00 35.71  ? 286 SER U CA   1 
ATOM   2023 C C    . SER A  1 286 ? 103.032 114.326 135.045 1.00 40.11  ? 286 SER U C    1 
ATOM   2024 O O    . SER A  1 286 ? 102.080 113.636 135.430 1.00 45.87  ? 286 SER U O    1 
ATOM   2025 C CB   . SER A  1 286 ? 102.565 116.331 133.613 1.00 38.74  ? 286 SER U CB   1 
ATOM   2026 O OG   . SER A  1 286 ? 103.634 116.103 132.715 1.00 44.59  ? 286 SER U OG   1 
ATOM   2027 N N    . LEU A  1 287 ? 104.176 113.784 134.623 1.00 42.53  ? 287 LEU U N    1 
ATOM   2028 C CA   . LEU A  1 287 ? 104.370 112.339 134.677 1.00 34.65  ? 287 LEU U CA   1 
ATOM   2029 C C    . LEU A  1 287 ? 104.315 111.831 136.109 1.00 38.65  ? 287 LEU U C    1 
ATOM   2030 O O    . LEU A  1 287 ? 103.718 110.782 136.382 1.00 42.45  ? 287 LEU U O    1 
ATOM   2031 C CB   . LEU A  1 287 ? 105.700 111.953 134.031 1.00 38.47  ? 287 LEU U CB   1 
ATOM   2032 C CG   . LEU A  1 287 ? 105.787 111.990 132.508 1.00 39.03  ? 287 LEU U CG   1 
ATOM   2033 C CD1  . LEU A  1 287 ? 107.161 111.540 132.058 1.00 36.26  ? 287 LEU U CD1  1 
ATOM   2034 C CD2  . LEU A  1 287 ? 104.713 111.119 131.893 1.00 39.31  ? 287 LEU U CD2  1 
ATOM   2035 N N    . ASN A  1 288 ? 104.946 112.519 137.048 1.00 47.74  ? 288 ASN U N    1 
ATOM   2036 C CA   . ASN A  1 288 ? 104.974 112.014 138.436 1.00 42.28  ? 288 ASN U CA   1 
ATOM   2037 C C    . ASN A  1 288 ? 103.540 111.962 138.941 1.00 46.41  ? 288 ASN U C    1 
ATOM   2038 O O    . ASN A  1 288 ? 103.219 111.042 139.677 1.00 49.43  ? 288 ASN U O    1 
ATOM   2039 C CB   . ASN A  1 288 ? 105.805 112.899 139.348 1.00 43.58  ? 288 ASN U CB   1 
ATOM   2040 C CG   . ASN A  1 288 ? 107.238 112.451 139.473 1.00 48.58  ? 288 ASN U CG   1 
ATOM   2041 O OD1  . ASN A  1 288 ? 107.561 111.636 140.331 1.00 56.62  ? 288 ASN U OD1  1 
ATOM   2042 N ND2  . ASN A  1 288 ? 108.101 112.986 138.630 1.00 47.84  ? 288 ASN U ND2  1 
ATOM   2043 N N    . TRP A  1 289 ? 102.754 112.985 138.589 1.00 52.22  ? 289 TRP U N    1 
ATOM   2044 C CA   . TRP A  1 289 ? 101.350 113.092 139.064 1.00 50.77  ? 289 TRP U CA   1 
ATOM   2045 C C    . TRP A  1 289 ? 100.501 111.980 138.443 1.00 51.24  ? 289 TRP U C    1 
ATOM   2046 O O    . TRP A  1 289 ? 99.700  111.376 139.180 1.00 57.22  ? 289 TRP U O    1 
ATOM   2047 C CB   . TRP A  1 289 ? 100.798 114.483 138.726 1.00 54.38  ? 289 TRP U CB   1 
ATOM   2048 C CG   . TRP A  1 289 ? 99.318  114.625 138.912 1.00 56.97  ? 289 TRP U CG   1 
ATOM   2049 C CD1  . TRP A  1 289 ? 98.674  115.144 139.997 1.00 54.41  ? 289 TRP U CD1  1 
ATOM   2050 C CD2  . TRP A  1 289 ? 98.291  114.253 137.976 1.00 57.19  ? 289 TRP U CD2  1 
ATOM   2051 N NE1  . TRP A  1 289 ? 97.319  115.115 139.805 1.00 50.74  ? 289 TRP U NE1  1 
ATOM   2052 C CE2  . TRP A  1 289 ? 97.054  114.573 138.575 1.00 53.52  ? 289 TRP U CE2  1 
ATOM   2053 C CE3  . TRP A  1 289 ? 98.293  113.678 136.701 1.00 56.19  ? 289 TRP U CE3  1 
ATOM   2054 C CZ2  . TRP A  1 289 ? 95.837  114.338 137.938 1.00 53.77  ? 289 TRP U CZ2  1 
ATOM   2055 C CZ3  . TRP A  1 289 ? 97.090  113.444 136.074 1.00 55.36  ? 289 TRP U CZ3  1 
ATOM   2056 C CH2  . TRP A  1 289 ? 95.880  113.772 136.685 1.00 54.18  ? 289 TRP U CH2  1 
ATOM   2057 N N    . ILE A  1 290 ? 100.668 111.725 137.142 1.00 53.57  ? 290 ILE U N    1 
ATOM   2058 C CA   . ILE A  1 290 ? 99.907  110.635 136.540 1.00 54.34  ? 290 ILE U CA   1 
ATOM   2059 C C    . ILE A  1 290 ? 100.283 109.302 137.177 1.00 54.30  ? 290 ILE U C    1 
ATOM   2060 O O    . ILE A  1 290 ? 99.418  108.453 137.429 1.00 54.95  ? 290 ILE U O    1 
ATOM   2061 C CB   . ILE A  1 290 ? 100.101 110.615 135.014 1.00 51.85  ? 290 ILE U CB   1 
ATOM   2062 C CG1  . ILE A  1 290 ? 99.375  109.421 134.401 1.00 52.64  ? 290 ILE U CG1  1 
ATOM   2063 C CG2  . ILE A  1 290 ? 101.567 110.574 134.658 1.00 52.91  ? 290 ILE U CG2  1 
ATOM   2064 C CD1  . ILE A  1 290 ? 99.501  109.350 132.901 1.00 56.16  ? 290 ILE U CD1  1 
ATOM   2065 N N    . LEU A  1 291 ? 101.573 109.095 137.451 1.00 57.50  ? 291 LEU U N    1 
ATOM   2066 C CA   . LEU A  1 291 ? 101.984 107.868 138.127 1.00 53.44  ? 291 LEU U CA   1 
ATOM   2067 C C    . LEU A  1 291 ? 101.336 107.753 139.498 1.00 53.17  ? 291 LEU U C    1 
ATOM   2068 O O    . LEU A  1 291 ? 100.850 106.682 139.874 1.00 53.50  ? 291 LEU U O    1 
ATOM   2069 C CB   . LEU A  1 291 ? 103.505 107.813 138.251 1.00 50.12  ? 291 LEU U CB   1 
ATOM   2070 C CG   . LEU A  1 291 ? 104.273 107.428 136.990 1.00 49.00  ? 291 LEU U CG   1 
ATOM   2071 C CD1  . LEU A  1 291 ? 105.764 107.466 137.254 1.00 52.82  ? 291 LEU U CD1  1 
ATOM   2072 C CD2  . LEU A  1 291 ? 103.845 106.054 136.523 1.00 49.90  ? 291 LEU U CD2  1 
ATOM   2073 N N    . ARG A  1 292 ? 101.311 108.849 140.260 1.00 66.45  ? 292 ARG U N    1 
ATOM   2074 C CA   . ARG A  1 292 ? 100.648 108.808 141.560 1.00 66.97  ? 292 ARG U CA   1 
ATOM   2075 C C    . ARG A  1 292 ? 99.161  108.517 141.404 1.00 67.13  ? 292 ARG U C    1 
ATOM   2076 O O    . ARG A  1 292 ? 98.573  107.791 142.214 1.00 66.29  ? 292 ARG U O    1 
ATOM   2077 C CB   . ARG A  1 292 ? 100.863 110.121 142.311 1.00 67.43  ? 292 ARG U CB   1 
ATOM   2078 C CG   . ARG A  1 292 ? 102.308 110.377 142.696 1.00 68.69  ? 292 ARG U CG   1 
ATOM   2079 C CD   . ARG A  1 292 ? 102.425 111.530 143.678 1.00 69.98  ? 292 ARG U CD   1 
ATOM   2080 N NE   . ARG A  1 292 ? 103.813 111.794 144.038 1.00 72.56  ? 292 ARG U NE   1 
ATOM   2081 C CZ   . ARG A  1 292 ? 104.555 112.758 143.509 1.00 72.50  ? 292 ARG U CZ   1 
ATOM   2082 N NH1  . ARG A  1 292 ? 104.065 113.589 142.603 1.00 70.25  ? 292 ARG U NH1  1 
ATOM   2083 N NH2  . ARG A  1 292 ? 105.819 112.894 143.900 1.00 71.29  ? 292 ARG U NH2  1 
ATOM   2084 N N    . LYS A  1 293 ? 98.536  109.076 140.367 1.00 74.21  ? 293 LYS U N    1 
ATOM   2085 C CA   . LYS A  1 293 ? 97.120  108.817 140.132 1.00 76.45  ? 293 LYS U CA   1 
ATOM   2086 C C    . LYS A  1 293 ? 96.867  107.340 139.860 1.00 74.85  ? 293 LYS U C    1 
ATOM   2087 O O    . LYS A  1 293 ? 95.882  106.772 140.345 1.00 75.63  ? 293 LYS U O    1 
ATOM   2088 C CB   . LYS A  1 293 ? 96.615  109.669 138.968 1.00 75.65  ? 293 LYS U CB   1 
ATOM   2089 C CG   . LYS A  1 293 ? 95.170  109.405 138.590 1.00 74.29  ? 293 LYS U CG   1 
ATOM   2090 C CD   . LYS A  1 293 ? 94.263  109.510 139.800 1.00 75.20  ? 293 LYS U CD   1 
ATOM   2091 C CE   . LYS A  1 293 ? 94.498  110.809 140.550 1.00 74.80  ? 293 LYS U CE   1 
ATOM   2092 N NZ   . LYS A  1 293 ? 94.292  111.995 139.679 1.00 74.40  ? 293 LYS U NZ   1 
ATOM   2093 N N    . MET A  1 294 ? 97.744  106.700 139.087 1.00 79.04  ? 294 MET U N    1 
ATOM   2094 C CA   . MET A  1 294 ? 97.570  105.281 138.795 1.00 78.48  ? 294 MET U CA   1 
ATOM   2095 C C    . MET A  1 294 ? 97.746  104.400 140.024 1.00 81.12  ? 294 MET U C    1 
ATOM   2096 O O    . MET A  1 294 ? 97.428  103.207 139.956 1.00 81.15  ? 294 MET U O    1 
ATOM   2097 C CB   . MET A  1 294 ? 98.544  104.838 137.704 1.00 78.22  ? 294 MET U CB   1 
ATOM   2098 C CG   . MET A  1 294 ? 98.203  105.359 136.320 1.00 79.35  ? 294 MET U CG   1 
ATOM   2099 S SD   . MET A  1 294 ? 99.377  104.815 135.066 1.00 87.35  ? 294 MET U SD   1 
ATOM   2100 C CE   . MET A  1 294 ? 99.254  103.039 135.244 1.00 79.35  ? 294 MET U CE   1 
ATOM   2101 N N    . ASP A  1 295 ? 98.248  104.946 141.128 1.00 86.56  ? 295 ASP U N    1 
ATOM   2102 C CA   . ASP A  1 295 ? 98.427  104.191 142.365 1.00 84.90  ? 295 ASP U CA   1 
ATOM   2103 C C    . ASP A  1 295 ? 99.613  103.241 142.264 1.00 85.95  ? 295 ASP U C    1 
ATOM   2104 O O    . ASP A  1 295 ? 100.253 102.928 143.266 1.00 87.11  ? 295 ASP U O    1 
ATOM   2105 C CB   . ASP A  1 295 ? 97.159  103.411 142.713 1.00 84.81  ? 295 ASP U CB   1 
ATOM   2106 C CG   . ASP A  1 295 ? 95.946  104.307 142.861 1.00 87.99  ? 295 ASP U CG   1 
ATOM   2107 O OD1  . ASP A  1 295 ? 96.102  105.541 142.757 1.00 88.12  ? 295 ASP U OD1  1 
ATOM   2108 O OD2  . ASP A  1 295 ? 94.836  103.778 143.080 1.00 87.78  ? 295 ASP U OD2  1 
ATOM   2109 N N    . ASN B  1 14  ? 129.087 138.924 142.004 1.00 48.19  ? 14  ASN A N    1 
ATOM   2110 C CA   . ASN B  1 14  ? 130.029 139.420 141.011 1.00 50.98  ? 14  ASN A CA   1 
ATOM   2111 C C    . ASN B  1 14  ? 130.815 138.267 140.399 1.00 54.03  ? 14  ASN A C    1 
ATOM   2112 O O    . ASN B  1 14  ? 131.443 138.419 139.354 1.00 58.54  ? 14  ASN A O    1 
ATOM   2113 C CB   . ASN B  1 14  ? 130.982 140.442 141.632 1.00 50.72  ? 14  ASN A CB   1 
ATOM   2114 C CG   . ASN B  1 14  ? 131.842 141.147 140.600 1.00 51.34  ? 14  ASN A CG   1 
ATOM   2115 O OD1  . ASN B  1 14  ? 131.603 141.042 139.399 1.00 55.08  ? 14  ASN A OD1  1 
ATOM   2116 N ND2  . ASN B  1 14  ? 132.844 141.881 141.067 1.00 50.28  ? 14  ASN A ND2  1 
ATOM   2117 N N    . GLU B  1 15  ? 130.778 137.108 141.058 1.00 52.60  ? 15  GLU A N    1 
ATOM   2118 C CA   . GLU B  1 15  ? 131.463 135.937 140.520 1.00 51.84  ? 15  GLU A CA   1 
ATOM   2119 C C    . GLU B  1 15  ? 130.708 135.348 139.335 1.00 57.36  ? 15  GLU A C    1 
ATOM   2120 O O    . GLU B  1 15  ? 131.317 134.965 138.330 1.00 60.40  ? 15  GLU A O    1 
ATOM   2121 C CB   . GLU B  1 15  ? 131.646 134.889 141.612 1.00 51.79  ? 15  GLU A CB   1 
ATOM   2122 C CG   . GLU B  1 15  ? 132.299 133.609 141.128 1.00 58.41  ? 15  GLU A CG   1 
ATOM   2123 C CD   . GLU B  1 15  ? 132.448 132.581 142.228 1.00 66.22  ? 15  GLU A CD   1 
ATOM   2124 O OE1  . GLU B  1 15  ? 132.058 132.879 143.377 1.00 64.16  ? 15  GLU A OE1  1 
ATOM   2125 O OE2  . GLU B  1 15  ? 132.956 131.475 141.947 1.00 65.21  ? 15  GLU A OE2  1 
ATOM   2126 N N    . ASP B  1 16  ? 129.380 135.262 139.435 1.00 49.00  ? 16  ASP A N    1 
ATOM   2127 C CA   . ASP B  1 16  ? 128.594 134.712 138.335 1.00 45.43  ? 16  ASP A CA   1 
ATOM   2128 C C    . ASP B  1 16  ? 128.734 135.565 137.082 1.00 50.47  ? 16  ASP A C    1 
ATOM   2129 O O    . ASP B  1 16  ? 128.881 135.035 135.974 1.00 54.53  ? 16  ASP A O    1 
ATOM   2130 C CB   . ASP B  1 16  ? 127.128 134.596 138.746 1.00 48.88  ? 16  ASP A CB   1 
ATOM   2131 C CG   . ASP B  1 16  ? 126.929 133.689 139.941 1.00 55.57  ? 16  ASP A CG   1 
ATOM   2132 O OD1  . ASP B  1 16  ? 127.685 132.707 140.075 1.00 59.75  ? 16  ASP A OD1  1 
ATOM   2133 O OD2  . ASP B  1 16  ? 126.018 133.960 140.750 1.00 55.64  ? 16  ASP A OD2  1 
ATOM   2134 N N    . ASN B  1 17  ? 128.691 136.888 137.237 1.00 42.62  ? 17  ASN A N    1 
ATOM   2135 C CA   . ASN B  1 17  ? 128.875 137.768 136.090 1.00 44.43  ? 17  ASN A CA   1 
ATOM   2136 C C    . ASN B  1 17  ? 130.260 137.593 135.482 1.00 46.79  ? 17  ASN A C    1 
ATOM   2137 O O    . ASN B  1 17  ? 130.414 137.595 134.255 1.00 49.39  ? 17  ASN A O    1 
ATOM   2138 C CB   . ASN B  1 17  ? 128.649 139.219 136.503 1.00 47.08  ? 17  ASN A CB   1 
ATOM   2139 C CG   . ASN B  1 17  ? 127.298 139.437 137.141 1.00 50.07  ? 17  ASN A CG   1 
ATOM   2140 O OD1  . ASN B  1 17  ? 126.352 138.694 136.884 1.00 50.59  ? 17  ASN A OD1  1 
ATOM   2141 N ND2  . ASN B  1 17  ? 127.196 140.459 137.980 1.00 50.71  ? 17  ASN A ND2  1 
ATOM   2142 N N    . ALA B  1 18  ? 131.283 137.455 136.326 1.00 37.50  ? 18  ALA A N    1 
ATOM   2143 C CA   . ALA B  1 18  ? 132.632 137.250 135.816 1.00 37.22  ? 18  ALA A CA   1 
ATOM   2144 C C    . ALA B  1 18  ? 132.725 135.960 135.013 1.00 38.95  ? 18  ALA A C    1 
ATOM   2145 O O    . ALA B  1 18  ? 133.321 135.938 133.931 1.00 41.68  ? 18  ALA A O    1 
ATOM   2146 C CB   . ALA B  1 18  ? 133.634 137.239 136.968 1.00 35.46  ? 18  ALA A CB   1 
ATOM   2147 N N    . ARG B  1 19  ? 132.141 134.876 135.525 1.00 33.18  ? 19  ARG A N    1 
ATOM   2148 C CA   . ARG B  1 19  ? 132.166 133.618 134.786 1.00 30.81  ? 19  ARG A CA   1 
ATOM   2149 C C    . ARG B  1 19  ? 131.420 133.743 133.463 1.00 34.41  ? 19  ARG A C    1 
ATOM   2150 O O    . ARG B  1 19  ? 131.881 133.241 132.430 1.00 43.26  ? 19  ARG A O    1 
ATOM   2151 C CB   . ARG B  1 19  ? 131.576 132.496 135.639 1.00 30.47  ? 19  ARG A CB   1 
ATOM   2152 C CG   . ARG B  1 19  ? 131.350 131.206 134.881 1.00 35.64  ? 19  ARG A CG   1 
ATOM   2153 C CD   . ARG B  1 19  ? 131.127 130.029 135.814 1.00 35.11  ? 19  ARG A CD   1 
ATOM   2154 N NE   . ARG B  1 19  ? 130.063 130.271 136.779 1.00 36.95  ? 19  ARG A NE   1 
ATOM   2155 C CZ   . ARG B  1 19  ? 130.256 130.428 138.081 1.00 38.75  ? 19  ARG A CZ   1 
ATOM   2156 N NH1  . ARG B  1 19  ? 131.465 130.366 138.612 1.00 34.73  ? 19  ARG A NH1  1 
ATOM   2157 N NH2  . ARG B  1 19  ? 129.209 130.646 138.870 1.00 40.19  ? 19  ARG A NH2  1 
ATOM   2158 N N    . PHE B  1 20  ? 130.270 134.419 133.475 1.00 27.79  ? 20  PHE A N    1 
ATOM   2159 C CA   . PHE B  1 20  ? 129.501 134.611 132.249 1.00 24.91  ? 20  PHE A CA   1 
ATOM   2160 C C    . PHE B  1 20  ? 130.318 135.363 131.205 1.00 30.25  ? 20  PHE A C    1 
ATOM   2161 O O    . PHE B  1 20  ? 130.413 134.944 130.042 1.00 35.76  ? 20  PHE A O    1 
ATOM   2162 C CB   . PHE B  1 20  ? 128.213 135.364 132.589 1.00 21.20  ? 20  PHE A CB   1 
ATOM   2163 C CG   . PHE B  1 20  ? 127.143 135.258 131.548 1.00 28.02  ? 20  PHE A CG   1 
ATOM   2164 C CD1  . PHE B  1 20  ? 126.816 134.040 130.990 1.00 30.29  ? 20  PHE A CD1  1 
ATOM   2165 C CD2  . PHE B  1 20  ? 126.434 136.379 131.155 1.00 25.33  ? 20  PHE A CD2  1 
ATOM   2166 C CE1  . PHE B  1 20  ? 125.822 133.946 130.040 1.00 32.16  ? 20  PHE A CE1  1 
ATOM   2167 C CE2  . PHE B  1 20  ? 125.440 136.289 130.209 1.00 22.01  ? 20  PHE A CE2  1 
ATOM   2168 C CZ   . PHE B  1 20  ? 125.133 135.072 129.650 1.00 26.37  ? 20  PHE A CZ   1 
ATOM   2169 N N    . LEU B  1 21  ? 130.937 136.472 131.613 1.00 26.75  ? 21  LEU A N    1 
ATOM   2170 C CA   . LEU B  1 21  ? 131.730 137.273 130.688 1.00 24.16  ? 21  LEU A CA   1 
ATOM   2171 C C    . LEU B  1 21  ? 132.926 136.491 130.160 1.00 30.70  ? 21  LEU A C    1 
ATOM   2172 O O    . LEU B  1 21  ? 133.244 136.552 128.963 1.00 37.08  ? 21  LEU A O    1 
ATOM   2173 C CB   . LEU B  1 21  ? 132.185 138.553 131.384 1.00 24.50  ? 21  LEU A CB   1 
ATOM   2174 C CG   . LEU B  1 21  ? 132.954 139.577 130.559 1.00 27.40  ? 21  LEU A CG   1 
ATOM   2175 C CD1  . LEU B  1 21  ? 132.089 140.095 129.428 1.00 31.40  ? 21  LEU A CD1  1 
ATOM   2176 C CD2  . LEU B  1 21  ? 133.416 140.714 131.449 1.00 23.54  ? 21  LEU A CD2  1 
ATOM   2177 N N    . LEU B  1 22  ? 133.610 135.755 131.039 1.00 27.21  ? 22  LEU A N    1 
ATOM   2178 C CA   . LEU B  1 22  ? 134.764 134.977 130.609 1.00 28.63  ? 22  LEU A CA   1 
ATOM   2179 C C    . LEU B  1 22  ? 134.365 133.921 129.590 1.00 34.28  ? 22  LEU A C    1 
ATOM   2180 O O    . LEU B  1 22  ? 135.050 133.732 128.577 1.00 41.51  ? 22  LEU A O    1 
ATOM   2181 C CB   . LEU B  1 22  ? 135.431 134.332 131.822 1.00 28.61  ? 22  LEU A CB   1 
ATOM   2182 C CG   . LEU B  1 22  ? 136.716 133.546 131.577 1.00 32.80  ? 22  LEU A CG   1 
ATOM   2183 C CD1  . LEU B  1 22  ? 137.815 134.468 131.091 1.00 30.81  ? 22  LEU A CD1  1 
ATOM   2184 C CD2  . LEU B  1 22  ? 137.138 132.829 132.841 1.00 28.32  ? 22  LEU A CD2  1 
ATOM   2185 N N    . LEU B  1 23  ? 133.254 133.225 129.835 1.00 21.41  ? 23  LEU A N    1 
ATOM   2186 C CA   . LEU B  1 23  ? 132.801 132.221 128.882 1.00 18.49  ? 23  LEU A CA   1 
ATOM   2187 C C    . LEU B  1 23  ? 132.458 132.857 127.542 1.00 28.52  ? 23  LEU A C    1 
ATOM   2188 O O    . LEU B  1 23  ? 132.786 132.306 126.484 1.00 33.30  ? 23  LEU A O    1 
ATOM   2189 C CB   . LEU B  1 23  ? 131.600 131.466 129.444 1.00 20.62  ? 23  LEU A CB   1 
ATOM   2190 C CG   . LEU B  1 23  ? 131.116 130.288 128.602 1.00 26.15  ? 23  LEU A CG   1 
ATOM   2191 C CD1  . LEU B  1 23  ? 132.251 129.314 128.359 1.00 25.82  ? 23  LEU A CD1  1 
ATOM   2192 C CD2  . LEU B  1 23  ? 129.957 129.594 129.283 1.00 22.54  ? 23  LEU A CD2  1 
ATOM   2193 N N    . ALA B  1 24  ? 131.801 134.018 127.565 1.00 29.28  ? 24  ALA A N    1 
ATOM   2194 C CA   . ALA B  1 24  ? 131.467 134.687 126.310 1.00 21.50  ? 24  ALA A CA   1 
ATOM   2195 C C    . ALA B  1 24  ? 132.725 135.030 125.518 1.00 32.75  ? 24  ALA A C    1 
ATOM   2196 O O    . ALA B  1 24  ? 132.807 134.772 124.309 1.00 37.84  ? 24  ALA A O    1 
ATOM   2197 C CB   . ALA B  1 24  ? 130.646 135.944 126.590 1.00 17.15  ? 24  ALA A CB   1 
ATOM   2198 N N    . ALA B  1 25  ? 133.724 135.610 126.189 1.00 26.83  ? 25  ALA A N    1 
ATOM   2199 C CA   . ALA B  1 25  ? 134.951 135.983 125.490 1.00 23.00  ? 25  ALA A CA   1 
ATOM   2200 C C    . ALA B  1 25  ? 135.656 134.759 124.919 1.00 28.27  ? 25  ALA A C    1 
ATOM   2201 O O    . ALA B  1 25  ? 136.132 134.777 123.772 1.00 32.13  ? 25  ALA A O    1 
ATOM   2202 C CB   . ALA B  1 25  ? 135.880 136.747 126.431 1.00 19.06  ? 25  ALA A CB   1 
ATOM   2203 N N    . LEU B  1 26  ? 135.734 133.682 125.703 1.00 28.92  ? 26  LEU A N    1 
ATOM   2204 C CA   . LEU B  1 26  ? 136.395 132.478 125.217 1.00 23.88  ? 26  LEU A CA   1 
ATOM   2205 C C    . LEU B  1 26  ? 135.675 131.909 124.004 1.00 24.39  ? 26  LEU A C    1 
ATOM   2206 O O    . LEU B  1 26  ? 136.318 131.482 123.037 1.00 29.95  ? 26  LEU A O    1 
ATOM   2207 C CB   . LEU B  1 26  ? 136.482 131.438 126.331 1.00 27.38  ? 26  LEU A CB   1 
ATOM   2208 C CG   . LEU B  1 26  ? 137.358 131.814 127.524 1.00 23.13  ? 26  LEU A CG   1 
ATOM   2209 C CD1  . LEU B  1 26  ? 137.429 130.668 128.508 1.00 25.19  ? 26  LEU A CD1  1 
ATOM   2210 C CD2  . LEU B  1 26  ? 138.747 132.208 127.060 1.00 19.84  ? 26  LEU A CD2  1 
ATOM   2211 N N    . ILE B  1 27  ? 134.341 131.898 124.026 1.00 17.88  ? 27  ILE A N    1 
ATOM   2212 C CA   . ILE B  1 27  ? 133.602 131.365 122.887 1.00 20.60  ? 27  ILE A CA   1 
ATOM   2213 C C    . ILE B  1 27  ? 133.825 132.224 121.650 1.00 21.87  ? 27  ILE A C    1 
ATOM   2214 O O    . ILE B  1 27  ? 133.928 131.706 120.532 1.00 23.18  ? 27  ILE A O    1 
ATOM   2215 C CB   . ILE B  1 27  ? 132.108 131.236 123.221 1.00 24.97  ? 27  ILE A CB   1 
ATOM   2216 C CG1  . ILE B  1 27  ? 131.901 130.242 124.362 1.00 17.51  ? 27  ILE A CG1  1 
ATOM   2217 C CG2  . ILE B  1 27  ? 131.334 130.789 122.000 1.00 24.55  ? 27  ILE A CG2  1 
ATOM   2218 C CD1  . ILE B  1 27  ? 130.452 129.975 124.666 1.00 13.91  ? 27  ILE A CD1  1 
ATOM   2219 N N    . VAL B  1 28  ? 133.893 133.546 121.820 1.00 25.68  ? 28  VAL A N    1 
ATOM   2220 C CA   . VAL B  1 28  ? 134.132 134.415 120.668 1.00 26.08  ? 28  VAL A CA   1 
ATOM   2221 C C    . VAL B  1 28  ? 135.495 134.117 120.048 1.00 25.70  ? 28  VAL A C    1 
ATOM   2222 O O    . VAL B  1 28  ? 135.631 133.990 118.820 1.00 31.35  ? 28  VAL A O    1 
ATOM   2223 C CB   . VAL B  1 28  ? 134.008 135.893 121.072 1.00 23.31  ? 28  VAL A CB   1 
ATOM   2224 C CG1  . VAL B  1 28  ? 134.479 136.785 119.942 1.00 22.69  ? 28  VAL A CG1  1 
ATOM   2225 C CG2  . VAL B  1 28  ? 132.575 136.214 121.437 1.00 22.44  ? 28  VAL A CG2  1 
ATOM   2226 N N    . LEU B  1 29  ? 136.528 134.006 120.887 1.00 20.49  ? 29  LEU A N    1 
ATOM   2227 C CA   . LEU B  1 29  ? 137.853 133.686 120.359 1.00 22.78  ? 29  LEU A CA   1 
ATOM   2228 C C    . LEU B  1 29  ? 137.855 132.329 119.666 1.00 29.21  ? 29  LEU A C    1 
ATOM   2229 O O    . LEU B  1 29  ? 138.482 132.156 118.611 1.00 32.33  ? 29  LEU A O    1 
ATOM   2230 C CB   . LEU B  1 29  ? 138.891 133.717 121.478 1.00 22.68  ? 29  LEU A CB   1 
ATOM   2231 C CG   . LEU B  1 29  ? 139.189 135.086 122.085 1.00 23.45  ? 29  LEU A CG   1 
ATOM   2232 C CD1  . LEU B  1 29  ? 140.294 134.975 123.116 1.00 19.38  ? 29  LEU A CD1  1 
ATOM   2233 C CD2  . LEU B  1 29  ? 139.565 136.075 121.002 1.00 24.02  ? 29  LEU A CD2  1 
ATOM   2234 N N    . TYR B  1 30  ? 137.162 131.354 120.255 1.00 23.09  ? 30  TYR A N    1 
ATOM   2235 C CA   . TYR B  1 30  ? 137.072 130.029 119.656 1.00 16.95  ? 30  TYR A CA   1 
ATOM   2236 C C    . TYR B  1 30  ? 136.445 130.099 118.271 1.00 20.61  ? 30  TYR A C    1 
ATOM   2237 O O    . TYR B  1 30  ? 136.941 129.477 117.322 1.00 26.85  ? 30  TYR A O    1 
ATOM   2238 C CB   . TYR B  1 30  ? 136.262 129.120 120.579 1.00 15.76  ? 30  TYR A CB   1 
ATOM   2239 C CG   . TYR B  1 30  ? 136.347 127.645 120.282 1.00 24.67  ? 30  TYR A CG   1 
ATOM   2240 C CD1  . TYR B  1 30  ? 137.509 126.934 120.529 1.00 17.47  ? 30  TYR A CD1  1 
ATOM   2241 C CD2  . TYR B  1 30  ? 135.251 126.957 119.788 1.00 19.98  ? 30  TYR A CD2  1 
ATOM   2242 C CE1  . TYR B  1 30  ? 137.585 125.586 120.270 1.00 14.58  ? 30  TYR A CE1  1 
ATOM   2243 C CE2  . TYR B  1 30  ? 135.318 125.608 119.528 1.00 20.06  ? 30  TYR A CE2  1 
ATOM   2244 C CZ   . TYR B  1 30  ? 136.486 124.928 119.771 1.00 16.71  ? 30  TYR A CZ   1 
ATOM   2245 O OH   . TYR B  1 30  ? 136.556 123.582 119.511 1.00 21.97  ? 30  TYR A OH   1 
ATOM   2246 N N    . LEU B  1 31  ? 135.357 130.859 118.135 1.00 16.04  ? 31  LEU A N    1 
ATOM   2247 C CA   . LEU B  1 31  ? 134.707 130.990 116.836 1.00 15.90  ? 31  LEU A CA   1 
ATOM   2248 C C    . LEU B  1 31  ? 135.639 131.622 115.812 1.00 19.08  ? 31  LEU A C    1 
ATOM   2249 O O    . LEU B  1 31  ? 135.722 131.156 114.669 1.00 25.25  ? 31  LEU A O    1 
ATOM   2250 C CB   . LEU B  1 31  ? 133.426 131.812 116.967 1.00 13.65  ? 31  LEU A CB   1 
ATOM   2251 C CG   . LEU B  1 31  ? 132.250 131.136 117.667 1.00 14.13  ? 31  LEU A CG   1 
ATOM   2252 C CD1  . LEU B  1 31  ? 131.056 132.067 117.704 1.00 13.06  ? 31  LEU A CD1  1 
ATOM   2253 C CD2  . LEU B  1 31  ? 131.896 129.843 116.965 1.00 16.25  ? 31  LEU A CD2  1 
ATOM   2254 N N    . LEU B  1 32  ? 136.344 132.688 116.195 1.00 15.99  ? 32  LEU A N    1 
ATOM   2255 C CA   . LEU B  1 32  ? 137.239 133.337 115.240 1.00 17.34  ? 32  LEU A CA   1 
ATOM   2256 C C    . LEU B  1 32  ? 138.329 132.378 114.766 1.00 22.69  ? 32  LEU A C    1 
ATOM   2257 O O    . LEU B  1 32  ? 138.592 132.254 113.558 1.00 24.74  ? 32  LEU A O    1 
ATOM   2258 C CB   . LEU B  1 32  ? 137.854 134.591 115.861 1.00 18.89  ? 32  LEU A CB   1 
ATOM   2259 C CG   . LEU B  1 32  ? 136.897 135.753 116.129 1.00 16.04  ? 32  LEU A CG   1 
ATOM   2260 C CD1  . LEU B  1 32  ? 137.648 136.944 116.691 1.00 18.72  ? 32  LEU A CD1  1 
ATOM   2261 C CD2  . LEU B  1 32  ? 136.159 136.138 114.864 1.00 20.19  ? 32  LEU A CD2  1 
ATOM   2262 N N    . GLY B  1 33  ? 138.968 131.677 115.706 1.00 23.06  ? 33  GLY A N    1 
ATOM   2263 C CA   . GLY B  1 33  ? 140.014 130.742 115.321 1.00 16.97  ? 33  GLY A CA   1 
ATOM   2264 C C    . GLY B  1 33  ? 139.502 129.626 114.430 1.00 22.97  ? 33  GLY A C    1 
ATOM   2265 O O    . GLY B  1 33  ? 140.137 129.270 113.428 1.00 28.07  ? 33  GLY A O    1 
ATOM   2266 N N    . GLY B  1 34  ? 138.350 129.053 114.782 1.00 20.18  ? 34  GLY A N    1 
ATOM   2267 C CA   . GLY B  1 34  ? 137.786 127.999 113.959 1.00 14.81  ? 34  GLY A CA   1 
ATOM   2268 C C    . GLY B  1 34  ? 137.465 128.469 112.556 1.00 23.05  ? 34  GLY A C    1 
ATOM   2269 O O    . GLY B  1 34  ? 137.702 127.752 111.581 1.00 30.21  ? 34  GLY A O    1 
ATOM   2270 N N    . ALA B  1 35  ? 136.912 129.677 112.431 1.00 18.25  ? 35  ALA A N    1 
ATOM   2271 C CA   . ALA B  1 35  ? 136.615 130.207 111.107 1.00 15.49  ? 35  ALA A CA   1 
ATOM   2272 C C    . ALA B  1 35  ? 137.884 130.334 110.280 1.00 16.68  ? 35  ALA A C    1 
ATOM   2273 O O    . ALA B  1 35  ? 137.922 129.935 109.108 1.00 24.65  ? 35  ALA A O    1 
ATOM   2274 C CB   . ALA B  1 35  ? 135.914 131.559 111.226 1.00 15.13  ? 35  ALA A CB   1 
ATOM   2275 N N    . ALA B  1 36  ? 138.944 130.880 110.880 1.00 21.13  ? 36  ALA A N    1 
ATOM   2276 C CA   . ALA B  1 36  ? 140.195 131.020 110.141 1.00 18.72  ? 36  ALA A CA   1 
ATOM   2277 C C    . ALA B  1 36  ? 140.699 129.665 109.660 1.00 26.35  ? 36  ALA A C    1 
ATOM   2278 O O    . ALA B  1 36  ? 141.069 129.502 108.488 1.00 31.18  ? 36  ALA A O    1 
ATOM   2279 C CB   . ALA B  1 36  ? 141.245 131.708 111.010 1.00 16.79  ? 36  ALA A CB   1 
ATOM   2280 N N    . VAL B  1 37  ? 140.703 128.670 110.551 1.00 25.79  ? 37  VAL A N    1 
ATOM   2281 C CA   . VAL B  1 37  ? 141.253 127.364 110.194 1.00 22.04  ? 37  VAL A CA   1 
ATOM   2282 C C    . VAL B  1 37  ? 140.429 126.715 109.087 1.00 24.04  ? 37  VAL A C    1 
ATOM   2283 O O    . VAL B  1 37  ? 140.974 126.175 108.116 1.00 28.80  ? 37  VAL A O    1 
ATOM   2284 C CB   . VAL B  1 37  ? 141.341 126.458 111.433 1.00 21.80  ? 37  VAL A CB   1 
ATOM   2285 C CG1  . VAL B  1 37  ? 141.732 125.056 111.024 1.00 24.44  ? 37  VAL A CG1  1 
ATOM   2286 C CG2  . VAL B  1 37  ? 142.345 127.018 112.420 1.00 21.90  ? 37  VAL A CG2  1 
ATOM   2287 N N    . PHE B  1 38  ? 139.100 126.747 109.219 1.00 21.84  ? 38  PHE A N    1 
ATOM   2288 C CA   . PHE B  1 38  ? 138.256 126.110 108.214 1.00 17.75  ? 38  PHE A CA   1 
ATOM   2289 C C    . PHE B  1 38  ? 138.413 126.777 106.856 1.00 23.04  ? 38  PHE A C    1 
ATOM   2290 O O    . PHE B  1 38  ? 138.465 126.095 105.823 1.00 24.14  ? 38  PHE A O    1 
ATOM   2291 C CB   . PHE B  1 38  ? 136.795 126.133 108.655 1.00 10.59  ? 38  PHE A CB   1 
ATOM   2292 C CG   . PHE B  1 38  ? 136.398 124.949 109.481 1.00 21.85  ? 38  PHE A CG   1 
ATOM   2293 C CD1  . PHE B  1 38  ? 136.279 123.700 108.904 1.00 17.13  ? 38  PHE A CD1  1 
ATOM   2294 C CD2  . PHE B  1 38  ? 136.134 125.085 110.829 1.00 24.63  ? 38  PHE A CD2  1 
ATOM   2295 C CE1  . PHE B  1 38  ? 135.912 122.610 109.658 1.00 20.28  ? 38  PHE A CE1  1 
ATOM   2296 C CE2  . PHE B  1 38  ? 135.766 123.998 111.586 1.00 17.31  ? 38  PHE A CE2  1 
ATOM   2297 C CZ   . PHE B  1 38  ? 135.654 122.760 111.001 1.00 20.78  ? 38  PHE A CZ   1 
ATOM   2298 N N    . SER B  1 39  ? 138.470 128.110 106.826 1.00 27.25  ? 39  SER A N    1 
ATOM   2299 C CA   . SER B  1 39  ? 138.702 128.787 105.558 1.00 24.09  ? 39  SER A CA   1 
ATOM   2300 C C    . SER B  1 39  ? 140.011 128.324 104.938 1.00 27.58  ? 39  SER A C    1 
ATOM   2301 O O    . SER B  1 39  ? 140.061 127.951 103.758 1.00 32.19  ? 39  SER A O    1 
ATOM   2302 C CB   . SER B  1 39  ? 138.709 130.300 105.764 1.00 22.31  ? 39  SER A CB   1 
ATOM   2303 O OG   . SER B  1 39  ? 139.148 130.962 104.592 1.00 31.03  ? 39  SER A OG   1 
ATOM   2304 N N    . ALA B  1 40  ? 141.083 128.317 105.736 1.00 31.53  ? 40  ALA A N    1 
ATOM   2305 C CA   . ALA B  1 40  ? 142.381 127.898 105.218 1.00 25.87  ? 40  ALA A CA   1 
ATOM   2306 C C    . ALA B  1 40  ? 142.321 126.486 104.655 1.00 24.16  ? 40  ALA A C    1 
ATOM   2307 O O    . ALA B  1 40  ? 142.997 126.174 103.669 1.00 31.68  ? 40  ALA A O    1 
ATOM   2308 C CB   . ALA B  1 40  ? 143.440 127.991 106.314 1.00 26.14  ? 40  ALA A CB   1 
ATOM   2309 N N    . LEU B  1 41  ? 141.526 125.613 105.272 1.00 28.54  ? 41  LEU A N    1 
ATOM   2310 C CA   . LEU B  1 41  ? 141.459 124.232 104.806 1.00 20.92  ? 41  LEU A CA   1 
ATOM   2311 C C    . LEU B  1 41  ? 140.615 124.067 103.545 1.00 28.85  ? 41  LEU A C    1 
ATOM   2312 O O    . LEU B  1 41  ? 140.922 123.202 102.718 1.00 29.80  ? 41  LEU A O    1 
ATOM   2313 C CB   . LEU B  1 41  ? 140.914 123.325 105.909 1.00 18.23  ? 41  LEU A CB   1 
ATOM   2314 C CG   . LEU B  1 41  ? 141.852 123.001 107.072 1.00 21.82  ? 41  LEU A CG   1 
ATOM   2315 C CD1  . LEU B  1 41  ? 141.151 122.117 108.085 1.00 20.50  ? 41  LEU A CD1  1 
ATOM   2316 C CD2  . LEU B  1 41  ? 143.115 122.335 106.569 1.00 20.82  ? 41  LEU A CD2  1 
ATOM   2317 N N    . GLU B  1 42  ? 139.559 124.867 103.371 1.00 34.56  ? 42  GLU A N    1 
ATOM   2318 C CA   . GLU B  1 42  ? 138.551 124.560 102.361 1.00 24.31  ? 42  GLU A CA   1 
ATOM   2319 C C    . GLU B  1 42  ? 138.529 125.479 101.143 1.00 27.81  ? 42  GLU A C    1 
ATOM   2320 O O    . GLU B  1 42  ? 137.924 125.103 100.127 1.00 36.11  ? 42  GLU A O    1 
ATOM   2321 C CB   . GLU B  1 42  ? 137.156 124.579 102.998 1.00 29.43  ? 42  GLU A CB   1 
ATOM   2322 C CG   . GLU B  1 42  ? 136.975 123.582 104.122 1.00 22.50  ? 42  GLU A CG   1 
ATOM   2323 C CD   . GLU B  1 42  ? 136.766 122.176 103.616 1.00 33.36  ? 42  GLU A CD   1 
ATOM   2324 O OE1  . GLU B  1 42  ? 136.753 121.985 102.385 1.00 44.51  ? 42  GLU A OE1  1 
ATOM   2325 O OE2  . GLU B  1 42  ? 136.608 121.261 104.448 1.00 39.30  ? 42  GLU A OE2  1 
ATOM   2326 N N    . LEU B  1 43  ? 139.139 126.666 101.211 1.00 30.18  ? 43  LEU A N    1 
ATOM   2327 C CA   . LEU B  1 43  ? 138.942 127.640 100.139 1.00 30.93  ? 43  LEU A CA   1 
ATOM   2328 C C    . LEU B  1 43  ? 139.443 127.122 98.793  1.00 36.37  ? 43  LEU A C    1 
ATOM   2329 O O    . LEU B  1 43  ? 138.766 127.281 97.766  1.00 41.23  ? 43  LEU A O    1 
ATOM   2330 C CB   . LEU B  1 43  ? 139.633 128.953 100.496 1.00 35.12  ? 43  LEU A CB   1 
ATOM   2331 C CG   . LEU B  1 43  ? 139.383 130.101 99.522  1.00 33.81  ? 43  LEU A CG   1 
ATOM   2332 C CD1  . LEU B  1 43  ? 137.896 130.362 99.398  1.00 33.93  ? 43  LEU A CD1  1 
ATOM   2333 C CD2  . LEU B  1 43  ? 140.109 131.347 99.980  1.00 36.19  ? 43  LEU A CD2  1 
ATOM   2334 N N    . ALA B  1 44  ? 140.635 126.523 98.769  1.00 37.74  ? 44  ALA A N    1 
ATOM   2335 C CA   . ALA B  1 44  ? 141.209 126.078 97.504  1.00 35.21  ? 44  ALA A CA   1 
ATOM   2336 C C    . ALA B  1 44  ? 140.350 125.001 96.856  1.00 44.03  ? 44  ALA A C    1 
ATOM   2337 O O    . ALA B  1 44  ? 140.109 125.031 95.642  1.00 50.94  ? 44  ALA A O    1 
ATOM   2338 C CB   . ALA B  1 44  ? 142.631 125.568 97.722  1.00 37.95  ? 44  ALA A CB   1 
ATOM   2339 N N    . HIS B  1 45  ? 139.880 124.040 97.651  1.00 40.46  ? 45  HIS A N    1 
ATOM   2340 C CA   . HIS B  1 45  ? 139.019 122.997 97.110  1.00 37.20  ? 45  HIS A CA   1 
ATOM   2341 C C    . HIS B  1 45  ? 137.731 123.588 96.558  1.00 43.50  ? 45  HIS A C    1 
ATOM   2342 O O    . HIS B  1 45  ? 137.261 123.180 95.489  1.00 47.21  ? 45  HIS A O    1 
ATOM   2343 C CB   . HIS B  1 45  ? 138.714 121.957 98.185  1.00 39.19  ? 45  HIS A CB   1 
ATOM   2344 C CG   . HIS B  1 45  ? 137.896 120.804 97.695  1.00 46.84  ? 45  HIS A CG   1 
ATOM   2345 N ND1  . HIS B  1 45  ? 138.430 119.776 96.950  1.00 49.92  ? 45  HIS A ND1  1 
ATOM   2346 C CD2  . HIS B  1 45  ? 136.582 120.518 97.843  1.00 46.84  ? 45  HIS A CD2  1 
ATOM   2347 C CE1  . HIS B  1 45  ? 137.480 118.905 96.660  1.00 45.75  ? 45  HIS A CE1  1 
ATOM   2348 N NE2  . HIS B  1 45  ? 136.348 119.332 97.190  1.00 43.48  ? 45  HIS A NE2  1 
ATOM   2349 N N    . GLU B  1 46  ? 137.144 124.553 97.272  1.00 43.66  ? 46  GLU A N    1 
ATOM   2350 C CA   . GLU B  1 46  ? 135.913 125.160 96.775  1.00 37.87  ? 46  GLU A CA   1 
ATOM   2351 C C    . GLU B  1 46  ? 136.140 125.831 95.426  1.00 36.21  ? 46  GLU A C    1 
ATOM   2352 O O    . GLU B  1 46  ? 135.351 125.656 94.488  1.00 42.39  ? 46  GLU A O    1 
ATOM   2353 C CB   . GLU B  1 46  ? 135.377 126.171 97.787  1.00 40.29  ? 46  GLU A CB   1 
ATOM   2354 C CG   . GLU B  1 46  ? 134.033 126.754 97.402  1.00 43.59  ? 46  GLU A CG   1 
ATOM   2355 C CD   . GLU B  1 46  ? 133.876 128.192 97.841  1.00 47.72  ? 46  GLU A CD   1 
ATOM   2356 O OE1  . GLU B  1 46  ? 134.904 128.873 98.024  1.00 47.25  ? 46  GLU A OE1  1 
ATOM   2357 O OE2  . GLU B  1 46  ? 132.725 128.643 98.003  1.00 49.91  ? 46  GLU A OE2  1 
ATOM   2358 N N    . ARG B  1 47  ? 137.222 126.602 95.311  1.00 39.02  ? 47  ARG A N    1 
ATOM   2359 C CA   . ARG B  1 47  ? 137.493 127.290 94.051  1.00 41.15  ? 47  ARG A CA   1 
ATOM   2360 C C    . ARG B  1 47  ? 137.725 126.297 92.920  1.00 44.84  ? 47  ARG A C    1 
ATOM   2361 O O    . ARG B  1 47  ? 137.228 126.487 91.801  1.00 50.11  ? 47  ARG A O    1 
ATOM   2362 C CB   . ARG B  1 47  ? 138.692 128.222 94.205  1.00 44.16  ? 47  ARG A CB   1 
ATOM   2363 C CG   . ARG B  1 47  ? 138.405 129.451 95.042  1.00 47.09  ? 47  ARG A CG   1 
ATOM   2364 C CD   . ARG B  1 47  ? 139.634 130.329 95.176  1.00 48.60  ? 47  ARG A CD   1 
ATOM   2365 N NE   . ARG B  1 47  ? 139.349 131.540 95.936  1.00 52.63  ? 47  ARG A NE   1 
ATOM   2366 C CZ   . ARG B  1 47  ? 140.263 132.429 96.298  1.00 54.11  ? 47  ARG A CZ   1 
ATOM   2367 N NH1  . ARG B  1 47  ? 141.539 132.272 95.991  1.00 51.42  ? 47  ARG A NH1  1 
ATOM   2368 N NH2  . ARG B  1 47  ? 139.887 133.502 96.988  1.00 53.39  ? 47  ARG A NH2  1 
ATOM   2369 N N    . GLN B  1 48  ? 138.481 125.232 93.190  1.00 47.76  ? 48  GLN A N    1 
ATOM   2370 C CA   . GLN B  1 48  ? 138.742 124.243 92.151  1.00 48.19  ? 48  GLN A CA   1 
ATOM   2371 C C    . GLN B  1 48  ? 137.454 123.573 91.692  1.00 48.10  ? 48  GLN A C    1 
ATOM   2372 O O    . GLN B  1 48  ? 137.245 123.365 90.490  1.00 49.85  ? 48  GLN A O    1 
ATOM   2373 C CB   . GLN B  1 48  ? 139.741 123.208 92.659  1.00 48.45  ? 48  GLN A CB   1 
ATOM   2374 C CG   . GLN B  1 48  ? 140.252 122.263 91.594  1.00 51.87  ? 48  GLN A CG   1 
ATOM   2375 C CD   . GLN B  1 48  ? 141.362 121.370 92.103  1.00 57.21  ? 48  GLN A CD   1 
ATOM   2376 O OE1  . GLN B  1 48  ? 141.829 121.524 93.231  1.00 56.97  ? 48  GLN A OE1  1 
ATOM   2377 N NE2  . GLN B  1 48  ? 141.793 120.428 91.272  1.00 56.44  ? 48  GLN A NE2  1 
ATOM   2378 N N    . ALA B  1 49  ? 136.573 123.231 92.635  1.00 46.75  ? 49  ALA A N    1 
ATOM   2379 C CA   . ALA B  1 49  ? 135.305 122.612 92.264  1.00 43.58  ? 49  ALA A CA   1 
ATOM   2380 C C    . ALA B  1 49  ? 134.460 123.551 91.417  1.00 46.98  ? 49  ALA A C    1 
ATOM   2381 O O    . ALA B  1 49  ? 133.846 123.126 90.429  1.00 47.80  ? 49  ALA A O    1 
ATOM   2382 C CB   . ALA B  1 49  ? 134.541 122.187 93.517  1.00 41.97  ? 49  ALA A CB   1 
ATOM   2383 N N    . LYS B  1 50  ? 134.402 124.830 91.793  1.00 47.12  ? 50  LYS A N    1 
ATOM   2384 C CA   . LYS B  1 50  ? 133.631 125.781 90.999  1.00 43.25  ? 50  LYS A CA   1 
ATOM   2385 C C    . LYS B  1 50  ? 134.180 125.884 89.583  1.00 44.40  ? 50  LYS A C    1 
ATOM   2386 O O    . LYS B  1 50  ? 133.416 125.901 88.609  1.00 51.51  ? 50  LYS A O    1 
ATOM   2387 C CB   . LYS B  1 50  ? 133.624 127.154 91.669  1.00 42.91  ? 50  LYS A CB   1 
ATOM   2388 C CG   . LYS B  1 50  ? 132.659 127.274 92.831  1.00 44.61  ? 50  LYS A CG   1 
ATOM   2389 C CD   . LYS B  1 50  ? 132.555 128.713 93.299  1.00 44.77  ? 50  LYS A CD   1 
ATOM   2390 C CE   . LYS B  1 50  ? 131.478 128.875 94.355  1.00 47.08  ? 50  LYS A CE   1 
ATOM   2391 N NZ   . LYS B  1 50  ? 131.755 128.052 95.560  1.00 47.46  ? 50  LYS A NZ   1 
ATOM   2392 N N    . GLN B  1 51  ? 135.505 125.951 89.447  1.00 46.74  ? 51  GLN A N    1 
ATOM   2393 C CA   . GLN B  1 51  ? 136.095 126.033 88.115  1.00 45.60  ? 51  GLN A CA   1 
ATOM   2394 C C    . GLN B  1 51  ? 135.769 124.795 87.291  1.00 48.38  ? 51  GLN A C    1 
ATOM   2395 O O    . GLN B  1 51  ? 135.441 124.897 86.101  1.00 53.49  ? 51  GLN A O    1 
ATOM   2396 C CB   . GLN B  1 51  ? 137.605 126.222 88.223  1.00 47.31  ? 51  GLN A CB   1 
ATOM   2397 C CG   . GLN B  1 51  ? 138.321 126.221 86.889  1.00 50.83  ? 51  GLN A CG   1 
ATOM   2398 C CD   . GLN B  1 51  ? 139.821 126.337 87.044  1.00 57.63  ? 51  GLN A CD   1 
ATOM   2399 O OE1  . GLN B  1 51  ? 140.332 126.493 88.153  1.00 60.21  ? 51  GLN A OE1  1 
ATOM   2400 N NE2  . GLN B  1 51  ? 140.539 126.260 85.930  1.00 52.21  ? 51  GLN A NE2  1 
ATOM   2401 N N    . ARG B  1 52  ? 135.856 123.613 87.906  1.00 48.92  ? 52  ARG A N    1 
ATOM   2402 C CA   . ARG B  1 52  ? 135.554 122.388 87.173  1.00 47.21  ? 52  ARG A CA   1 
ATOM   2403 C C    . ARG B  1 52  ? 134.103 122.364 86.711  1.00 48.65  ? 52  ARG A C    1 
ATOM   2404 O O    . ARG B  1 52  ? 133.813 121.986 85.568  1.00 51.77  ? 52  ARG A O    1 
ATOM   2405 C CB   . ARG B  1 52  ? 135.865 121.165 88.034  1.00 44.30  ? 52  ARG A CB   1 
ATOM   2406 C CG   . ARG B  1 52  ? 135.435 119.857 87.405  1.00 45.55  ? 52  ARG A CG   1 
ATOM   2407 C CD   . ARG B  1 52  ? 136.141 118.664 88.029  1.00 46.70  ? 52  ARG A CD   1 
ATOM   2408 N NE   . ARG B  1 52  ? 135.976 118.611 89.476  1.00 50.98  ? 52  ARG A NE   1 
ATOM   2409 C CZ   . ARG B  1 52  ? 136.931 118.897 90.349  1.00 51.99  ? 52  ARG A CZ   1 
ATOM   2410 N NH1  . ARG B  1 52  ? 138.143 119.254 89.955  1.00 48.24  ? 52  ARG A NH1  1 
ATOM   2411 N NH2  . ARG B  1 52  ? 136.668 118.817 91.649  1.00 49.04  ? 52  ARG A NH2  1 
ATOM   2412 N N    . TRP B  1 53  ? 133.174 122.765 87.582  1.00 47.23  ? 53  TRP A N    1 
ATOM   2413 C CA   . TRP B  1 53  ? 131.773 122.797 87.172  1.00 42.94  ? 53  TRP A CA   1 
ATOM   2414 C C    . TRP B  1 53  ? 131.557 123.773 86.028  1.00 40.74  ? 53  TRP A C    1 
ATOM   2415 O O    . TRP B  1 53  ? 130.804 123.484 85.091  1.00 44.18  ? 53  TRP A O    1 
ATOM   2416 C CB   . TRP B  1 53  ? 130.864 123.173 88.338  1.00 41.92  ? 53  TRP A CB   1 
ATOM   2417 C CG   . TRP B  1 53  ? 129.620 123.867 87.864  1.00 40.36  ? 53  TRP A CG   1 
ATOM   2418 C CD1  . TRP B  1 53  ? 129.305 125.181 88.025  1.00 43.70  ? 53  TRP A CD1  1 
ATOM   2419 C CD2  . TRP B  1 53  ? 128.543 123.286 87.116  1.00 43.17  ? 53  TRP A CD2  1 
ATOM   2420 N NE1  . TRP B  1 53  ? 128.093 125.454 87.442  1.00 41.86  ? 53  TRP A NE1  1 
ATOM   2421 C CE2  . TRP B  1 53  ? 127.605 124.307 86.876  1.00 42.49  ? 53  TRP A CE2  1 
ATOM   2422 C CE3  . TRP B  1 53  ? 128.278 122.002 86.635  1.00 42.86  ? 53  TRP A CE3  1 
ATOM   2423 C CZ2  . TRP B  1 53  ? 126.424 124.083 86.177  1.00 40.67  ? 53  TRP A CZ2  1 
ATOM   2424 C CZ3  . TRP B  1 53  ? 127.104 121.783 85.942  1.00 41.71  ? 53  TRP A CZ3  1 
ATOM   2425 C CH2  . TRP B  1 53  ? 126.192 122.817 85.719  1.00 37.46  ? 53  TRP A CH2  1 
ATOM   2426 N N    . GLU B  1 54  ? 132.177 124.951 86.100  1.00 52.55  ? 54  GLU A N    1 
ATOM   2427 C CA   . GLU B  1 54  ? 132.003 125.919 85.026  1.00 50.00  ? 54  GLU A CA   1 
ATOM   2428 C C    . GLU B  1 54  ? 132.518 125.360 83.708  1.00 52.57  ? 54  GLU A C    1 
ATOM   2429 O O    . GLU B  1 54  ? 131.882 125.530 82.660  1.00 56.40  ? 54  GLU A O    1 
ATOM   2430 C CB   . GLU B  1 54  ? 132.709 127.228 85.374  1.00 50.99  ? 54  GLU A CB   1 
ATOM   2431 C CG   . GLU B  1 54  ? 132.078 128.456 84.741  1.00 55.90  ? 54  GLU A CG   1 
ATOM   2432 C CD   . GLU B  1 54  ? 132.197 128.468 83.231  1.00 62.55  ? 54  GLU A CD   1 
ATOM   2433 O OE1  . GLU B  1 54  ? 133.172 127.892 82.704  1.00 60.55  ? 54  GLU A OE1  1 
ATOM   2434 O OE2  . GLU B  1 54  ? 131.315 129.053 82.569  1.00 62.04  ? 54  GLU A OE2  1 
ATOM   2435 N N    . GLU B  1 55  ? 133.670 124.689 83.740  1.00 55.75  ? 55  GLU A N    1 
ATOM   2436 C CA   . GLU B  1 55  ? 134.195 124.091 82.518  1.00 53.92  ? 55  GLU A CA   1 
ATOM   2437 C C    . GLU B  1 55  ? 133.245 123.036 81.967  1.00 55.71  ? 55  GLU A C    1 
ATOM   2438 O O    . GLU B  1 55  ? 132.998 122.983 80.757  1.00 55.08  ? 55  GLU A O    1 
ATOM   2439 C CB   . GLU B  1 55  ? 135.573 123.488 82.773  1.00 52.34  ? 55  GLU A CB   1 
ATOM   2440 C CG   . GLU B  1 55  ? 136.128 122.724 81.589  1.00 58.03  ? 55  GLU A CG   1 
ATOM   2441 C CD   . GLU B  1 55  ? 136.192 123.568 80.332  1.00 62.19  ? 55  GLU A CD   1 
ATOM   2442 O OE1  . GLU B  1 55  ? 136.005 124.798 80.430  1.00 62.80  ? 55  GLU A OE1  1 
ATOM   2443 O OE2  . GLU B  1 55  ? 136.426 123.001 79.244  1.00 61.97  ? 55  GLU A OE2  1 
ATOM   2444 N N    . ARG B  1 56  ? 132.702 122.184 82.842  1.00 57.52  ? 56  ARG A N    1 
ATOM   2445 C CA   . ARG B  1 56  ? 131.767 121.162 82.382  1.00 49.35  ? 56  ARG A CA   1 
ATOM   2446 C C    . ARG B  1 56  ? 130.534 121.789 81.747  1.00 52.71  ? 56  ARG A C    1 
ATOM   2447 O O    . ARG B  1 56  ? 130.071 121.339 80.692  1.00 55.24  ? 56  ARG A O    1 
ATOM   2448 C CB   . ARG B  1 56  ? 131.359 120.257 83.541  1.00 46.44  ? 56  ARG A CB   1 
ATOM   2449 C CG   . ARG B  1 56  ? 132.436 119.304 84.001  1.00 49.61  ? 56  ARG A CG   1 
ATOM   2450 C CD   . ARG B  1 56  ? 132.002 118.569 85.252  1.00 50.63  ? 56  ARG A CD   1 
ATOM   2451 N NE   . ARG B  1 56  ? 132.991 117.588 85.677  1.00 51.72  ? 56  ARG A NE   1 
ATOM   2452 C CZ   . ARG B  1 56  ? 132.935 116.918 86.819  1.00 52.86  ? 56  ARG A CZ   1 
ATOM   2453 N NH1  . ARG B  1 56  ? 131.955 117.109 87.685  1.00 51.41  ? 56  ARG A NH1  1 
ATOM   2454 N NH2  . ARG B  1 56  ? 133.889 116.036 87.101  1.00 53.90  ? 56  ARG A NH2  1 
ATOM   2455 N N    . LEU B  1 57  ? 129.981 122.822 82.382  1.00 51.45  ? 57  LEU A N    1 
ATOM   2456 C CA   . LEU B  1 57  ? 128.793 123.472 81.841  1.00 48.76  ? 57  LEU A CA   1 
ATOM   2457 C C    . LEU B  1 57  ? 129.077 124.094 80.483  1.00 53.44  ? 57  LEU A C    1 
ATOM   2458 O O    . LEU B  1 57  ? 128.274 123.966 79.552  1.00 54.60  ? 57  LEU A O    1 
ATOM   2459 C CB   . LEU B  1 57  ? 128.283 124.530 82.816  1.00 46.39  ? 57  LEU A CB   1 
ATOM   2460 C CG   . LEU B  1 57  ? 127.258 125.510 82.250  1.00 48.60  ? 57  LEU A CG   1 
ATOM   2461 C CD1  . LEU B  1 57  ? 126.024 124.772 81.775  1.00 53.15  ? 57  LEU A CD1  1 
ATOM   2462 C CD2  . LEU B  1 57  ? 126.893 126.553 83.288  1.00 51.76  ? 57  LEU A CD2  1 
ATOM   2463 N N    . ALA B  1 58  ? 130.216 124.777 80.349  1.00 60.89  ? 58  ALA A N    1 
ATOM   2464 C CA   . ALA B  1 58  ? 130.553 125.381 79.066  1.00 60.99  ? 58  ALA A CA   1 
ATOM   2465 C C    . ALA B  1 58  ? 130.719 124.320 77.988  1.00 63.23  ? 58  ALA A C    1 
ATOM   2466 O O    . ALA B  1 58  ? 130.246 124.492 76.857  1.00 61.34  ? 58  ALA A O    1 
ATOM   2467 C CB   . ALA B  1 58  ? 131.824 126.218 79.197  1.00 62.41  ? 58  ALA A CB   1 
ATOM   2468 N N    . GLN B  1 59  ? 131.390 123.214 78.317  1.00 68.46  ? 59  GLN A N    1 
ATOM   2469 C CA   . GLN B  1 59  ? 131.585 122.159 77.329  1.00 65.56  ? 59  GLN A CA   1 
ATOM   2470 C C    . GLN B  1 59  ? 130.253 121.556 76.903  1.00 67.61  ? 59  GLN A C    1 
ATOM   2471 O O    . GLN B  1 59  ? 130.024 121.319 75.712  1.00 67.39  ? 59  GLN A O    1 
ATOM   2472 C CB   . GLN B  1 59  ? 132.511 121.080 77.888  1.00 66.39  ? 59  GLN A CB   1 
ATOM   2473 C CG   . GLN B  1 59  ? 133.367 120.393 76.838  1.00 69.92  ? 59  GLN A CG   1 
ATOM   2474 C CD   . GLN B  1 59  ? 132.545 119.644 75.810  1.00 73.19  ? 59  GLN A CD   1 
ATOM   2475 O OE1  . GLN B  1 59  ? 131.478 119.115 76.117  1.00 70.63  ? 59  GLN A OE1  1 
ATOM   2476 N NE2  . GLN B  1 59  ? 133.038 119.598 74.579  1.00 70.68  ? 59  GLN A NE2  1 
ATOM   2477 N N    . PHE B  1 60  ? 129.359 121.301 77.862  1.00 67.06  ? 60  PHE A N    1 
ATOM   2478 C CA   . PHE B  1 60  ? 128.054 120.745 77.517  1.00 66.30  ? 60  PHE A CA   1 
ATOM   2479 C C    . PHE B  1 60  ? 127.262 121.708 76.645  1.00 65.30  ? 60  PHE A C    1 
ATOM   2480 O O    . PHE B  1 60  ? 126.627 121.294 75.669  1.00 60.36  ? 60  PHE A O    1 
ATOM   2481 C CB   . PHE B  1 60  ? 127.274 120.403 78.785  1.00 62.35  ? 60  PHE A CB   1 
ATOM   2482 C CG   . PHE B  1 60  ? 125.912 119.824 78.523  1.00 62.86  ? 60  PHE A CG   1 
ATOM   2483 C CD1  . PHE B  1 60  ? 125.751 118.468 78.309  1.00 62.76  ? 60  PHE A CD1  1 
ATOM   2484 C CD2  . PHE B  1 60  ? 124.792 120.635 78.501  1.00 63.82  ? 60  PHE A CD2  1 
ATOM   2485 C CE1  . PHE B  1 60  ? 124.501 117.934 78.071  1.00 59.59  ? 60  PHE A CE1  1 
ATOM   2486 C CE2  . PHE B  1 60  ? 123.541 120.104 78.264  1.00 59.72  ? 60  PHE A CE2  1 
ATOM   2487 C CZ   . PHE B  1 60  ? 123.396 118.753 78.049  1.00 57.95  ? 60  PHE A CZ   1 
ATOM   2488 N N    . SER B  1 61  ? 127.284 122.999 76.980  1.00 72.32  ? 61  SER A N    1 
ATOM   2489 C CA   . SER B  1 61  ? 126.556 123.975 76.178  1.00 70.47  ? 61  SER A CA   1 
ATOM   2490 C C    . SER B  1 61  ? 127.101 124.043 74.758  1.00 70.19  ? 61  SER A C    1 
ATOM   2491 O O    . SER B  1 61  ? 126.332 124.118 73.794  1.00 69.46  ? 61  SER A O    1 
ATOM   2492 C CB   . SER B  1 61  ? 126.618 125.351 76.837  1.00 70.55  ? 61  SER A CB   1 
ATOM   2493 O OG   . SER B  1 61  ? 126.072 126.340 75.984  1.00 72.64  ? 61  SER A OG   1 
ATOM   2494 N N    . ARG B  1 62  ? 128.426 124.024 74.609  1.00 73.64  ? 62  ARG A N    1 
ATOM   2495 C CA   . ARG B  1 62  ? 129.009 124.100 73.273  1.00 75.37  ? 62  ARG A CA   1 
ATOM   2496 C C    . ARG B  1 62  ? 128.737 122.831 72.474  1.00 75.30  ? 62  ARG A C    1 
ATOM   2497 O O    . ARG B  1 62  ? 128.542 122.889 71.256  1.00 74.86  ? 62  ARG A O    1 
ATOM   2498 C CB   . ARG B  1 62  ? 130.512 124.363 73.368  1.00 75.97  ? 62  ARG A CB   1 
ATOM   2499 C CG   . ARG B  1 62  ? 131.214 124.408 72.021  1.00 75.52  ? 62  ARG A CG   1 
ATOM   2500 C CD   . ARG B  1 62  ? 132.690 124.733 72.171  1.00 75.91  ? 62  ARG A CD   1 
ATOM   2501 N NE   . ARG B  1 62  ? 133.376 123.781 73.036  1.00 78.11  ? 62  ARG A NE   1 
ATOM   2502 C CZ   . ARG B  1 62  ? 133.645 123.992 74.318  1.00 78.00  ? 62  ARG A CZ   1 
ATOM   2503 N NH1  . ARG B  1 62  ? 133.311 125.123 74.917  1.00 75.08  ? 62  ARG A NH1  1 
ATOM   2504 N NH2  . ARG B  1 62  ? 134.266 123.045 75.014  1.00 74.55  ? 62  ARG A NH2  1 
ATOM   2505 N N    . GLY B  1 63  ? 128.723 121.676 73.141  1.00 74.35  ? 63  GLY A N    1 
ATOM   2506 C CA   . GLY B  1 63  ? 128.569 120.423 72.419  1.00 74.98  ? 63  GLY A CA   1 
ATOM   2507 C C    . GLY B  1 63  ? 127.234 120.311 71.705  1.00 75.58  ? 63  GLY A C    1 
ATOM   2508 O O    . GLY B  1 63  ? 127.170 119.911 70.541  1.00 75.54  ? 63  GLY A O    1 
ATOM   2509 N N    . HIS B  1 64  ? 126.150 120.664 72.395  1.00 75.11  ? 64  HIS A N    1 
ATOM   2510 C CA   . HIS B  1 64  ? 124.804 120.529 71.857  1.00 73.32  ? 64  HIS A CA   1 
ATOM   2511 C C    . HIS B  1 64  ? 124.246 121.851 71.341  1.00 73.62  ? 64  HIS A C    1 
ATOM   2512 O O    . HIS B  1 64  ? 123.044 121.944 71.071  1.00 72.13  ? 64  HIS A O    1 
ATOM   2513 C CB   . HIS B  1 64  ? 123.872 119.936 72.912  1.00 74.91  ? 64  HIS A CB   1 
ATOM   2514 C CG   . HIS B  1 64  ? 124.296 118.585 73.396  1.00 73.39  ? 64  HIS A CG   1 
ATOM   2515 N ND1  . HIS B  1 64  ? 125.299 118.408 74.324  1.00 73.20  ? 64  HIS A ND1  1 
ATOM   2516 C CD2  . HIS B  1 64  ? 123.856 117.345 73.076  1.00 72.64  ? 64  HIS A CD2  1 
ATOM   2517 C CE1  . HIS B  1 64  ? 125.457 117.118 74.558  1.00 73.04  ? 64  HIS A CE1  1 
ATOM   2518 N NE2  . HIS B  1 64  ? 124.593 116.451 73.813  1.00 73.69  ? 64  HIS A NE2  1 
ATOM   2519 N N    . GLN B  1 65  ? 125.093 122.870 71.208  1.00 78.65  ? 65  GLN A N    1 
ATOM   2520 C CA   . GLN B  1 65  ? 124.705 124.166 70.653  1.00 78.96  ? 65  GLN A CA   1 
ATOM   2521 C C    . GLN B  1 65  ? 123.398 124.666 71.265  1.00 76.83  ? 65  GLN A C    1 
ATOM   2522 O O    . GLN B  1 65  ? 122.461 125.060 70.567  1.00 72.98  ? 65  GLN A O    1 
ATOM   2523 C CB   . GLN B  1 65  ? 124.618 124.107 69.126  1.00 76.91  ? 65  GLN A CB   1 
ATOM   2524 C CG   . GLN B  1 65  ? 123.627 123.099 68.580  1.00 78.55  ? 65  GLN A CG   1 
ATOM   2525 C CD   . GLN B  1 65  ? 123.810 122.855 67.097  1.00 81.63  ? 65  GLN A CD   1 
ATOM   2526 O OE1  . GLN B  1 65  ? 124.648 123.484 66.451  1.00 79.89  ? 65  GLN A OE1  1 
ATOM   2527 N NE2  . GLN B  1 65  ? 123.028 121.932 66.547  1.00 81.00  ? 65  GLN A NE2  1 
ATOM   2528 N N    . LEU B  1 66  ? 123.341 124.643 72.592  1.00 76.28  ? 66  LEU A N    1 
ATOM   2529 C CA   . LEU B  1 66  ? 122.223 125.209 73.327  1.00 74.08  ? 66  LEU A CA   1 
ATOM   2530 C C    . LEU B  1 66  ? 122.530 126.655 73.702  1.00 75.34  ? 66  LEU A C    1 
ATOM   2531 O O    . LEU B  1 66  ? 123.525 127.242 73.270  1.00 76.93  ? 66  LEU A O    1 
ATOM   2532 C CB   . LEU B  1 66  ? 121.920 124.375 74.570  1.00 70.91  ? 66  LEU A CB   1 
ATOM   2533 C CG   . LEU B  1 66  ? 121.447 122.942 74.338  1.00 72.81  ? 66  LEU A CG   1 
ATOM   2534 C CD1  . LEU B  1 66  ? 121.145 122.268 75.661  1.00 72.51  ? 66  LEU A CD1  1 
ATOM   2535 C CD2  . LEU B  1 66  ? 120.229 122.928 73.436  1.00 74.34  ? 66  LEU A CD2  1 
ATOM   2536 N N    . SER B  1 67  ? 121.661 127.242 74.517  1.00 75.40  ? 67  SER A N    1 
ATOM   2537 C CA   . SER B  1 67  ? 121.837 128.596 75.014  1.00 73.46  ? 67  SER A CA   1 
ATOM   2538 C C    . SER B  1 67  ? 121.996 128.574 76.527  1.00 76.01  ? 67  SER A C    1 
ATOM   2539 O O    . SER B  1 67  ? 121.499 127.673 77.208  1.00 78.30  ? 67  SER A O    1 
ATOM   2540 C CB   . SER B  1 67  ? 120.653 129.485 74.628  1.00 73.12  ? 67  SER A CB   1 
ATOM   2541 O OG   . SER B  1 67  ? 120.807 130.790 75.155  1.00 76.39  ? 67  SER A OG   1 
ATOM   2542 N N    . ARG B  1 68  ? 122.701 129.577 77.050  1.00 75.10  ? 68  ARG A N    1 
ATOM   2543 C CA   . ARG B  1 68  ? 122.906 129.650 78.491  1.00 73.92  ? 68  ARG A CA   1 
ATOM   2544 C C    . ARG B  1 68  ? 121.583 129.819 79.229  1.00 74.85  ? 68  ARG A C    1 
ATOM   2545 O O    . ARG B  1 68  ? 121.366 129.204 80.279  1.00 76.39  ? 68  ARG A O    1 
ATOM   2546 C CB   . ARG B  1 68  ? 123.858 130.797 78.825  1.00 74.52  ? 68  ARG A CB   1 
ATOM   2547 C CG   . ARG B  1 68  ? 124.977 130.413 79.773  1.00 73.87  ? 68  ARG A CG   1 
ATOM   2548 C CD   . ARG B  1 68  ? 125.821 129.291 79.197  1.00 72.07  ? 68  ARG A CD   1 
ATOM   2549 N NE   . ARG B  1 68  ? 127.004 129.031 80.009  1.00 74.86  ? 68  ARG A NE   1 
ATOM   2550 C CZ   . ARG B  1 68  ? 128.209 129.518 79.752  1.00 75.82  ? 68  ARG A CZ   1 
ATOM   2551 N NH1  . ARG B  1 68  ? 128.436 130.282 78.696  1.00 74.53  ? 68  ARG A NH1  1 
ATOM   2552 N NH2  . ARG B  1 68  ? 129.213 129.229 80.574  1.00 73.99  ? 68  ARG A NH2  1 
ATOM   2553 N N    . ASP B  1 69  ? 120.685 130.649 78.693  1.00 73.89  ? 69  ASP A N    1 
ATOM   2554 C CA   . ASP B  1 69  ? 119.416 130.902 79.367  1.00 74.82  ? 69  ASP A CA   1 
ATOM   2555 C C    . ASP B  1 69  ? 118.563 129.642 79.446  1.00 75.53  ? 69  ASP A C    1 
ATOM   2556 O O    . ASP B  1 69  ? 117.901 129.392 80.461  1.00 76.00  ? 69  ASP A O    1 
ATOM   2557 C CB   . ASP B  1 69  ? 118.658 132.017 78.649  1.00 76.85  ? 69  ASP A CB   1 
ATOM   2558 C CG   . ASP B  1 69  ? 119.437 133.315 78.609  1.00 79.11  ? 69  ASP A CG   1 
ATOM   2559 O OD1  . ASP B  1 69  ? 120.192 133.584 79.566  1.00 78.53  ? 69  ASP A OD1  1 
ATOM   2560 O OD2  . ASP B  1 69  ? 119.298 134.065 77.620  1.00 78.97  ? 69  ASP A OD2  1 
ATOM   2561 N N    . GLU B  1 70  ? 118.544 128.846 78.377  1.00 68.19  ? 70  GLU A N    1 
ATOM   2562 C CA   . GLU B  1 70  ? 117.752 127.622 78.393  1.00 67.06  ? 70  GLU A CA   1 
ATOM   2563 C C    . GLU B  1 70  ? 118.254 126.660 79.461  1.00 68.84  ? 70  GLU A C    1 
ATOM   2564 O O    . GLU B  1 70  ? 117.458 126.070 80.204  1.00 69.46  ? 70  GLU A O    1 
ATOM   2565 C CB   . GLU B  1 70  ? 117.781 126.964 77.015  1.00 66.46  ? 70  GLU A CB   1 
ATOM   2566 C CG   . GLU B  1 70  ? 117.411 127.908 75.886  1.00 68.71  ? 70  GLU A CG   1 
ATOM   2567 C CD   . GLU B  1 70  ? 117.372 127.218 74.541  1.00 72.43  ? 70  GLU A CD   1 
ATOM   2568 O OE1  . GLU B  1 70  ? 117.305 125.972 74.513  1.00 75.17  ? 70  GLU A OE1  1 
ATOM   2569 O OE2  . GLU B  1 70  ? 117.409 127.921 73.509  1.00 71.19  ? 70  GLU A OE2  1 
ATOM   2570 N N    . LEU B  1 71  ? 119.572 126.493 79.558  1.00 60.49  ? 71  LEU A N    1 
ATOM   2571 C CA   . LEU B  1 71  ? 120.128 125.637 80.598  1.00 58.94  ? 71  LEU A CA   1 
ATOM   2572 C C    . LEU B  1 71  ? 119.842 126.203 81.980  1.00 57.87  ? 71  LEU A C    1 
ATOM   2573 O O    . LEU B  1 71  ? 119.600 125.451 82.929  1.00 59.63  ? 71  LEU A O    1 
ATOM   2574 C CB   . LEU B  1 71  ? 121.629 125.454 80.385  1.00 58.06  ? 71  LEU A CB   1 
ATOM   2575 C CG   . LEU B  1 71  ? 122.028 124.750 79.090  1.00 57.77  ? 71  LEU A CG   1 
ATOM   2576 C CD1  . LEU B  1 71  ? 123.535 124.599 79.006  1.00 59.77  ? 71  LEU A CD1  1 
ATOM   2577 C CD2  . LEU B  1 71  ? 121.350 123.398 78.987  1.00 57.13  ? 71  LEU A CD2  1 
ATOM   2578 N N    . ARG B  1 72  ? 119.868 127.530 82.117  1.00 57.02  ? 72  ARG A N    1 
ATOM   2579 C CA   . ARG B  1 72  ? 119.536 128.143 83.398  1.00 56.74  ? 72  ARG A CA   1 
ATOM   2580 C C    . ARG B  1 72  ? 118.108 127.808 83.807  1.00 60.16  ? 72  ARG A C    1 
ATOM   2581 O O    . ARG B  1 72  ? 117.845 127.453 84.961  1.00 61.14  ? 72  ARG A O    1 
ATOM   2582 C CB   . ARG B  1 72  ? 119.732 129.656 83.317  1.00 58.81  ? 72  ARG A CB   1 
ATOM   2583 C CG   . ARG B  1 72  ? 121.162 130.084 83.046  1.00 63.65  ? 72  ARG A CG   1 
ATOM   2584 C CD   . ARG B  1 72  ? 122.003 130.007 84.303  1.00 65.67  ? 72  ARG A CD   1 
ATOM   2585 N NE   . ARG B  1 72  ? 121.461 130.860 85.354  1.00 66.24  ? 72  ARG A NE   1 
ATOM   2586 C CZ   . ARG B  1 72  ? 121.671 132.166 85.438  1.00 65.09  ? 72  ARG A CZ   1 
ATOM   2587 N NH1  . ARG B  1 72  ? 122.408 132.807 84.545  1.00 62.27  ? 72  ARG A NH1  1 
ATOM   2588 N NH2  . ARG B  1 72  ? 121.126 132.847 86.441  1.00 64.02  ? 72  ARG A NH2  1 
ATOM   2589 N N    . GLY B  1 73  ? 117.170 127.916 82.868  1.00 56.30  ? 73  GLY A N    1 
ATOM   2590 C CA   . GLY B  1 73  ? 115.791 127.570 83.173  1.00 53.48  ? 73  GLY A CA   1 
ATOM   2591 C C    . GLY B  1 73  ? 115.625 126.102 83.520  1.00 51.19  ? 73  GLY A C    1 
ATOM   2592 O O    . GLY B  1 73  ? 114.906 125.749 84.462  1.00 52.32  ? 73  GLY A O    1 
ATOM   2593 N N    . PHE B  1 74  ? 116.290 125.228 82.765  1.00 43.38  ? 74  PHE A N    1 
ATOM   2594 C CA   . PHE B  1 74  ? 116.218 123.801 83.056  1.00 38.65  ? 74  PHE A CA   1 
ATOM   2595 C C    . PHE B  1 74  ? 116.758 123.498 84.448  1.00 42.86  ? 74  PHE A C    1 
ATOM   2596 O O    . PHE B  1 74  ? 116.163 122.718 85.201  1.00 42.35  ? 74  PHE A O    1 
ATOM   2597 C CB   . PHE B  1 74  ? 116.987 123.019 81.991  1.00 35.63  ? 74  PHE A CB   1 
ATOM   2598 C CG   . PHE B  1 74  ? 116.887 121.533 82.141  1.00 40.32  ? 74  PHE A CG   1 
ATOM   2599 C CD1  . PHE B  1 74  ? 115.713 120.874 81.832  1.00 37.92  ? 74  PHE A CD1  1 
ATOM   2600 C CD2  . PHE B  1 74  ? 117.969 120.794 82.575  1.00 41.72  ? 74  PHE A CD2  1 
ATOM   2601 C CE1  . PHE B  1 74  ? 115.619 119.507 81.963  1.00 38.68  ? 74  PHE A CE1  1 
ATOM   2602 C CE2  . PHE B  1 74  ? 117.880 119.427 82.707  1.00 41.97  ? 74  PHE A CE2  1 
ATOM   2603 C CZ   . PHE B  1 74  ? 116.704 118.782 82.401  1.00 40.99  ? 74  PHE A CZ   1 
ATOM   2604 N N    . LEU B  1 75  ? 117.880 124.118 84.815  1.00 44.78  ? 75  LEU A N    1 
ATOM   2605 C CA   . LEU B  1 75  ? 118.454 123.890 86.136  1.00 40.17  ? 75  LEU A CA   1 
ATOM   2606 C C    . LEU B  1 75  ? 117.578 124.468 87.238  1.00 42.89  ? 75  LEU A C    1 
ATOM   2607 O O    . LEU B  1 75  ? 117.512 123.900 88.331  1.00 44.90  ? 75  LEU A O    1 
ATOM   2608 C CB   . LEU B  1 75  ? 119.859 124.481 86.203  1.00 38.43  ? 75  LEU A CB   1 
ATOM   2609 C CG   . LEU B  1 75  ? 120.868 123.873 85.232  1.00 35.73  ? 75  LEU A CG   1 
ATOM   2610 C CD1  . LEU B  1 75  ? 122.210 124.561 85.367  1.00 37.31  ? 75  LEU A CD1  1 
ATOM   2611 C CD2  . LEU B  1 75  ? 121.002 122.384 85.476  1.00 38.23  ? 75  LEU A CD2  1 
ATOM   2612 N N    . ARG B  1 76  ? 116.910 125.592 86.981  1.00 42.14  ? 76  ARG A N    1 
ATOM   2613 C CA   . ARG B  1 76  ? 115.969 126.123 87.962  1.00 40.58  ? 76  ARG A CA   1 
ATOM   2614 C C    . ARG B  1 76  ? 114.822 125.148 88.196  1.00 44.67  ? 76  ARG A C    1 
ATOM   2615 O O    . ARG B  1 76  ? 114.433 124.887 89.345  1.00 42.59  ? 76  ARG A O    1 
ATOM   2616 C CB   . ARG B  1 76  ? 115.442 127.476 87.491  1.00 39.27  ? 76  ARG A CB   1 
ATOM   2617 C CG   . ARG B  1 76  ? 114.779 128.303 88.571  1.00 47.55  ? 76  ARG A CG   1 
ATOM   2618 C CD   . ARG B  1 76  ? 114.220 129.591 87.996  1.00 48.02  ? 76  ARG A CD   1 
ATOM   2619 N NE   . ARG B  1 76  ? 115.206 130.307 87.196  1.00 46.03  ? 76  ARG A NE   1 
ATOM   2620 C CZ   . ARG B  1 76  ? 116.047 131.211 87.677  1.00 48.75  ? 76  ARG A CZ   1 
ATOM   2621 N NH1  . ARG B  1 76  ? 116.056 131.533 88.960  1.00 47.01  ? 76  ARG A NH1  1 
ATOM   2622 N NH2  . ARG B  1 76  ? 116.901 131.807 86.850  1.00 48.24  ? 76  ARG A NH2  1 
ATOM   2623 N N    . HIS B  1 77  ? 114.277 124.588 87.115  1.00 43.50  ? 77  HIS A N    1 
ATOM   2624 C CA   . HIS B  1 77  ? 113.235 123.578 87.261  1.00 32.82  ? 77  HIS A CA   1 
ATOM   2625 C C    . HIS B  1 77  ? 113.748 122.375 88.039  1.00 37.14  ? 77  HIS A C    1 
ATOM   2626 O O    . HIS B  1 77  ? 113.036 121.821 88.885  1.00 38.72  ? 77  HIS A O    1 
ATOM   2627 C CB   . HIS B  1 77  ? 112.723 123.146 85.889  1.00 33.77  ? 77  HIS A CB   1 
ATOM   2628 C CG   . HIS B  1 77  ? 111.857 124.163 85.219  1.00 39.14  ? 77  HIS A CG   1 
ATOM   2629 N ND1  . HIS B  1 77  ? 111.387 124.009 83.933  1.00 40.35  ? 77  HIS A ND1  1 
ATOM   2630 C CD2  . HIS B  1 77  ? 111.367 125.346 85.660  1.00 39.02  ? 77  HIS A CD2  1 
ATOM   2631 C CE1  . HIS B  1 77  ? 110.650 125.056 83.608  1.00 38.30  ? 77  HIS A CE1  1 
ATOM   2632 N NE2  . HIS B  1 77  ? 110.621 125.881 84.639  1.00 41.87  ? 77  HIS A NE2  1 
ATOM   2633 N N    . TYR B  1 78  ? 114.980 121.948 87.760  1.00 39.52  ? 78  TYR A N    1 
ATOM   2634 C CA   . TYR B  1 78  ? 115.530 120.804 88.479  1.00 34.61  ? 78  TYR A CA   1 
ATOM   2635 C C    . TYR B  1 78  ? 115.713 121.111 89.959  1.00 36.02  ? 78  TYR A C    1 
ATOM   2636 O O    . TYR B  1 78  ? 115.503 120.238 90.804  1.00 47.68  ? 78  TYR A O    1 
ATOM   2637 C CB   . TYR B  1 78  ? 116.854 120.363 87.863  1.00 38.65  ? 78  TYR A CB   1 
ATOM   2638 C CG   . TYR B  1 78  ? 117.472 119.199 88.599  1.00 37.98  ? 78  TYR A CG   1 
ATOM   2639 C CD1  . TYR B  1 78  ? 116.939 117.926 88.492  1.00 36.01  ? 78  TYR A CD1  1 
ATOM   2640 C CD2  . TYR B  1 78  ? 118.579 119.378 89.411  1.00 36.85  ? 78  TYR A CD2  1 
ATOM   2641 C CE1  . TYR B  1 78  ? 117.493 116.862 89.166  1.00 32.52  ? 78  TYR A CE1  1 
ATOM   2642 C CE2  . TYR B  1 78  ? 119.141 118.320 90.089  1.00 40.40  ? 78  TYR A CE2  1 
ATOM   2643 C CZ   . TYR B  1 78  ? 118.593 117.064 89.963  1.00 40.97  ? 78  TYR A CZ   1 
ATOM   2644 O OH   . TYR B  1 78  ? 119.151 116.006 90.638  1.00 44.71  ? 78  TYR A OH   1 
ATOM   2645 N N    . GLU B  1 79  ? 116.066 122.340 90.288  1.00 38.22  ? 79  GLU A N    1 
ATOM   2646 C CA   . GLU B  1 79  ? 116.242 122.726 91.707  1.00 39.32  ? 79  GLU A CA   1 
ATOM   2647 C C    . GLU B  1 79  ? 114.890 122.709 92.398  1.00 42.96  ? 79  GLU A C    1 
ATOM   2648 O O    . GLU B  1 79  ? 114.842 122.328 93.559  1.00 44.41  ? 79  GLU A O    1 
ATOM   2649 C CB   . GLU B  1 79  ? 116.798 124.135 91.821  1.00 40.55  ? 79  GLU A CB   1 
ATOM   2650 C CG   . GLU B  1 79  ? 118.300 124.188 91.951  1.00 47.50  ? 79  GLU A CG   1 
ATOM   2651 C CD   . GLU B  1 79  ? 118.810 125.581 92.260  1.00 50.63  ? 79  GLU A CD   1 
ATOM   2652 O OE1  . GLU B  1 79  ? 118.056 126.357 92.868  1.00 49.19  ? 79  GLU A OE1  1 
ATOM   2653 O OE2  . GLU B  1 79  ? 119.952 125.887 91.884  1.00 53.41  ? 79  GLU A OE2  1 
ATOM   2654 N N    . GLU B  1 80  ? 113.845 123.159 91.717  1.00 42.29  ? 80  GLU A N    1 
ATOM   2655 C CA   . GLU B  1 80  ? 112.505 123.074 92.289  1.00 39.14  ? 80  GLU A CA   1 
ATOM   2656 C C    . GLU B  1 80  ? 112.099 121.622 92.511  1.00 41.61  ? 80  GLU A C    1 
ATOM   2657 O O    . GLU B  1 80  ? 111.579 121.266 93.577  1.00 38.99  ? 80  GLU A O    1 
ATOM   2658 C CB   . GLU B  1 80  ? 111.504 123.783 91.382  1.00 37.81  ? 80  GLU A CB   1 
ATOM   2659 C CG   . GLU B  1 80  ? 110.066 123.678 91.843  1.00 42.14  ? 80  GLU A CG   1 
ATOM   2660 C CD   . GLU B  1 80  ? 109.115 124.428 90.935  1.00 50.31  ? 80  GLU A CD   1 
ATOM   2661 O OE1  . GLU B  1 80  ? 109.591 125.236 90.111  1.00 48.77  ? 80  GLU A OE1  1 
ATOM   2662 O OE2  . GLU B  1 80  ? 107.890 124.207 91.040  1.00 51.96  ? 80  GLU A OE2  1 
ATOM   2663 N N    . ALA B  1 81  ? 112.350 120.763 91.523  1.00 44.29  ? 81  ALA A N    1 
ATOM   2664 C CA   . ALA B  1 81  ? 112.012 119.351 91.672  1.00 36.85  ? 81  ALA A CA   1 
ATOM   2665 C C    . ALA B  1 81  ? 112.775 118.721 92.829  1.00 35.35  ? 81  ALA A C    1 
ATOM   2666 O O    . ALA B  1 81  ? 112.208 117.951 93.611  1.00 39.22  ? 81  ALA A O    1 
ATOM   2667 C CB   . ALA B  1 81  ? 112.298 118.601 90.372  1.00 36.09  ? 81  ALA A CB   1 
ATOM   2668 N N    . THR B  1 82  ? 114.064 119.037 92.954  1.00 40.28  ? 82  THR A N    1 
ATOM   2669 C CA   . THR B  1 82  ? 114.865 118.487 94.043  1.00 39.72  ? 82  THR A CA   1 
ATOM   2670 C C    . THR B  1 82  ? 114.315 118.914 95.394  1.00 43.47  ? 82  THR A C    1 
ATOM   2671 O O    . THR B  1 82  ? 114.244 118.106 96.326  1.00 42.16  ? 82  THR A O    1 
ATOM   2672 C CB   . THR B  1 82  ? 116.321 118.922 93.899  1.00 40.84  ? 82  THR A CB   1 
ATOM   2673 O OG1  . THR B  1 82  ? 116.909 118.265 92.770  1.00 41.33  ? 82  THR A OG1  1 
ATOM   2674 C CG2  . THR B  1 82  ? 117.102 118.569 95.147  1.00 48.02  ? 82  THR A CG2  1 
ATOM   2675 N N    . ARG B  1 83  ? 113.926 120.183 95.524  1.00 50.97  ? 83  ARG A N    1 
ATOM   2676 C CA   . ARG B  1 83  ? 113.243 120.603 96.744  1.00 44.69  ? 83  ARG A CA   1 
ATOM   2677 C C    . ARG B  1 83  ? 111.974 119.791 96.956  1.00 45.53  ? 83  ARG A C    1 
ATOM   2678 O O    . ARG B  1 83  ? 111.607 119.484 98.094  1.00 48.42  ? 83  ARG A O    1 
ATOM   2679 C CB   . ARG B  1 83  ? 112.925 122.097 96.692  1.00 45.53  ? 83  ARG A CB   1 
ATOM   2680 C CG   . ARG B  1 83  ? 114.115 122.991 96.987  1.00 48.85  ? 83  ARG A CG   1 
ATOM   2681 C CD   . ARG B  1 83  ? 113.741 124.462 96.918  1.00 53.91  ? 83  ARG A CD   1 
ATOM   2682 N NE   . ARG B  1 83  ? 113.278 124.845 95.591  1.00 54.81  ? 83  ARG A NE   1 
ATOM   2683 C CZ   . ARG B  1 83  ? 113.062 126.095 95.203  1.00 56.34  ? 83  ARG A CZ   1 
ATOM   2684 N NH1  . ARG B  1 83  ? 113.268 127.116 96.018  1.00 54.04  ? 83  ARG A NH1  1 
ATOM   2685 N NH2  . ARG B  1 83  ? 112.633 126.326 93.967  1.00 48.35  ? 83  ARG A NH2  1 
ATOM   2686 N N    . ALA B  1 84  ? 111.292 119.429 95.867  1.00 48.09  ? 84  ALA A N    1 
ATOM   2687 C CA   . ALA B  1 84  ? 110.111 118.581 95.992  1.00 42.62  ? 84  ALA A CA   1 
ATOM   2688 C C    . ALA B  1 84  ? 110.468 117.216 96.565  1.00 37.45  ? 84  ALA A C    1 
ATOM   2689 O O    . ALA B  1 84  ? 109.724 116.664 97.382  1.00 45.96  ? 84  ALA A O    1 
ATOM   2690 C CB   . ALA B  1 84  ? 109.424 118.429 94.637  1.00 45.03  ? 84  ALA A CB   1 
ATOM   2691 N N    . GLY B  1 85  ? 111.597 116.652 96.144  1.00 41.62  ? 85  GLY A N    1 
ATOM   2692 C CA   . GLY B  1 85  ? 112.022 115.355 96.632  1.00 39.16  ? 85  GLY A CA   1 
ATOM   2693 C C    . GLY B  1 85  ? 112.643 114.480 95.562  1.00 43.25  ? 85  GLY A C    1 
ATOM   2694 O O    . GLY B  1 85  ? 113.099 113.371 95.847  1.00 46.93  ? 85  GLY A O    1 
ATOM   2695 N N    . ILE B  1 86  ? 112.669 114.973 94.323  1.00 45.08  ? 86  ILE A N    1 
ATOM   2696 C CA   . ILE B  1 86  ? 113.238 114.207 93.223  1.00 34.73  ? 86  ILE A CA   1 
ATOM   2697 C C    . ILE B  1 86  ? 114.752 114.165 93.351  1.00 38.76  ? 86  ILE A C    1 
ATOM   2698 O O    . ILE B  1 86  ? 115.388 115.128 93.801  1.00 45.15  ? 86  ILE A O    1 
ATOM   2699 C CB   . ILE B  1 86  ? 112.819 114.811 91.872  1.00 38.81  ? 86  ILE A CB   1 
ATOM   2700 C CG1  . ILE B  1 86  ? 111.350 114.509 91.587  1.00 40.00  ? 86  ILE A CG1  1 
ATOM   2701 C CG2  . ILE B  1 86  ? 113.694 114.271 90.758  1.00 38.99  ? 86  ILE A CG2  1 
ATOM   2702 C CD1  . ILE B  1 86  ? 111.074 113.050 91.337  1.00 42.50  ? 86  ILE A CD1  1 
ATOM   2703 N N    . ARG B  1 87  ? 115.340 113.042 92.955  1.00 48.68  ? 87  ARG A N    1 
ATOM   2704 C CA   . ARG B  1 87  ? 116.781 112.857 92.960  1.00 50.31  ? 87  ARG A CA   1 
ATOM   2705 C C    . ARG B  1 87  ? 117.191 112.227 91.635  1.00 48.57  ? 87  ARG A C    1 
ATOM   2706 O O    . ARG B  1 87  ? 116.385 112.096 90.710  1.00 51.59  ? 87  ARG A O    1 
ATOM   2707 C CB   . ARG B  1 87  ? 117.224 111.993 94.144  1.00 48.31  ? 87  ARG A CB   1 
ATOM   2708 C CG   . ARG B  1 87  ? 118.639 112.258 94.606  1.00 49.33  ? 87  ARG A CG   1 
ATOM   2709 C CD   . ARG B  1 87  ? 118.763 113.653 95.184  1.00 50.48  ? 87  ARG A CD   1 
ATOM   2710 N NE   . ARG B  1 87  ? 117.780 113.892 96.233  1.00 47.17  ? 87  ARG A NE   1 
ATOM   2711 C CZ   . ARG B  1 87  ? 117.735 114.985 96.982  1.00 52.06  ? 87  ARG A CZ   1 
ATOM   2712 N NH1  . ARG B  1 87  ? 118.611 115.963 96.830  1.00 52.22  ? 87  ARG A NH1  1 
ATOM   2713 N NH2  . ARG B  1 87  ? 116.788 115.099 97.908  1.00 49.46  ? 87  ARG A NH2  1 
ATOM   2714 N N    . VAL B  1 88  ? 118.457 111.831 91.540  1.00 53.34  ? 88  VAL A N    1 
ATOM   2715 C CA   . VAL B  1 88  ? 118.961 111.217 90.319  1.00 57.56  ? 88  VAL A CA   1 
ATOM   2716 C C    . VAL B  1 88  ? 119.145 109.707 90.445  1.00 59.33  ? 88  VAL A C    1 
ATOM   2717 O O    . VAL B  1 88  ? 119.232 109.021 89.416  1.00 55.88  ? 88  VAL A O    1 
ATOM   2718 C CB   . VAL B  1 88  ? 120.284 111.875 89.876  1.00 53.69  ? 88  VAL A CB   1 
ATOM   2719 C CG1  . VAL B  1 88  ? 120.791 111.236 88.597  1.00 51.80  ? 88  VAL A CG1  1 
ATOM   2720 C CG2  . VAL B  1 88  ? 120.087 113.363 89.679  1.00 50.03  ? 88  VAL A CG2  1 
ATOM   2721 N N    . ASP B  1 89  ? 119.198 109.166 91.667  1.00 60.32  ? 89  ASP A N    1 
ATOM   2722 C CA   . ASP B  1 89  ? 119.407 107.731 91.875  1.00 58.11  ? 89  ASP A CA   1 
ATOM   2723 C C    . ASP B  1 89  ? 118.316 107.175 92.789  1.00 61.69  ? 89  ASP A C    1 
ATOM   2724 O O    . ASP B  1 89  ? 118.523 107.020 93.994  1.00 68.66  ? 89  ASP A O    1 
ATOM   2725 C CB   . ASP B  1 89  ? 120.799 107.473 92.445  1.00 58.71  ? 89  ASP A CB   1 
ATOM   2726 C CG   . ASP B  1 89  ? 121.902 107.936 91.519  1.00 65.25  ? 89  ASP A CG   1 
ATOM   2727 O OD1  . ASP B  1 89  ? 121.660 108.006 90.297  1.00 67.62  ? 89  ASP A OD1  1 
ATOM   2728 O OD2  . ASP B  1 89  ? 123.012 108.227 92.012  1.00 64.43  ? 89  ASP A OD2  1 
ATOM   2729 N N    . ASN B  1 90  ? 117.160 106.880 92.202  1.00 54.21  ? 90  ASN A N    1 
ATOM   2730 C CA   . ASN B  1 90  ? 116.157 105.978 92.771  1.00 52.66  ? 90  ASN A CA   1 
ATOM   2731 C C    . ASN B  1 90  ? 116.058 106.100 94.291  1.00 55.22  ? 90  ASN A C    1 
ATOM   2732 O O    . ASN B  1 90  ? 116.272 105.144 95.036  1.00 57.57  ? 90  ASN A O    1 
ATOM   2733 C CB   . ASN B  1 90  ? 116.447 104.536 92.364  1.00 57.27  ? 90  ASN A CB   1 
ATOM   2734 C CG   . ASN B  1 90  ? 116.572 104.370 90.865  1.00 61.52  ? 90  ASN A CG   1 
ATOM   2735 O OD1  . ASN B  1 90  ? 115.928 105.083 90.095  1.00 60.75  ? 90  ASN A OD1  1 
ATOM   2736 N ND2  . ASN B  1 90  ? 117.405 103.428 90.442  1.00 57.12  ? 90  ASN A ND2  1 
ATOM   2737 N N    . VAL B  1 91  ? 115.732 107.299 94.750  1.00 43.22  ? 91  VAL A N    1 
ATOM   2738 C CA   . VAL B  1 91  ? 115.542 107.521 96.178  1.00 36.73  ? 91  VAL A CA   1 
ATOM   2739 C C    . VAL B  1 91  ? 114.170 107.011 96.599  1.00 38.96  ? 91  VAL A C    1 
ATOM   2740 O O    . VAL B  1 91  ? 113.235 106.929 95.796  1.00 38.35  ? 91  VAL A O    1 
ATOM   2741 C CB   . VAL B  1 91  ? 115.719 109.010 96.528  1.00 39.64  ? 91  VAL A CB   1 
ATOM   2742 C CG1  . VAL B  1 91  ? 117.167 109.421 96.355  1.00 39.31  ? 91  VAL A CG1  1 
ATOM   2743 C CG2  . VAL B  1 91  ? 114.813 109.861 95.663  1.00 45.08  ? 91  VAL A CG2  1 
ATOM   2744 N N    . ARG B  1 92  ? 114.050 106.665 97.876  1.00 35.94  ? 92  ARG A N    1 
ATOM   2745 C CA   . ARG B  1 92  ? 112.787 106.190 98.413  1.00 30.33  ? 92  ARG A CA   1 
ATOM   2746 C C    . ARG B  1 92  ? 111.757 107.316 98.422  1.00 37.67  ? 92  ARG A C    1 
ATOM   2747 O O    . ARG B  1 92  ? 112.111 108.490 98.552  1.00 47.63  ? 92  ARG A O    1 
ATOM   2748 C CB   . ARG B  1 92  ? 112.978 105.662 99.830  1.00 30.47  ? 92  ARG A CB   1 
ATOM   2749 C CG   . ARG B  1 92  ? 113.503 106.710 100.789 1.00 34.56  ? 92  ARG A CG   1 
ATOM   2750 C CD   . ARG B  1 92  ? 113.810 106.129 102.152 1.00 37.08  ? 92  ARG A CD   1 
ATOM   2751 N NE   . ARG B  1 92  ? 112.614 105.640 102.823 1.00 41.72  ? 92  ARG A NE   1 
ATOM   2752 C CZ   . ARG B  1 92  ? 112.583 105.217 104.078 1.00 37.11  ? 92  ARG A CZ   1 
ATOM   2753 N NH1  . ARG B  1 92  ? 113.667 105.223 104.834 1.00 31.40  ? 92  ARG A NH1  1 
ATOM   2754 N NH2  . ARG B  1 92  ? 111.437 104.779 104.588 1.00 36.44  ? 92  ARG A NH2  1 
ATOM   2755 N N    . PRO B  1 93  ? 110.475 106.986 98.288  1.00 34.81  ? 93  PRO A N    1 
ATOM   2756 C CA   . PRO B  1 93  ? 109.448 108.031 98.295  1.00 26.54  ? 93  PRO A CA   1 
ATOM   2757 C C    . PRO B  1 93  ? 109.411 108.768 99.624  1.00 27.59  ? 93  PRO A C    1 
ATOM   2758 O O    . PRO B  1 93  ? 109.621 108.189 100.689 1.00 37.32  ? 93  PRO A O    1 
ATOM   2759 C CB   . PRO B  1 93  ? 108.151 107.254 98.052  1.00 22.21  ? 93  PRO A CB   1 
ATOM   2760 C CG   . PRO B  1 93  ? 108.447 105.882 98.532  1.00 30.05  ? 93  PRO A CG   1 
ATOM   2761 C CD   . PRO B  1 93  ? 109.889 105.640 98.201  1.00 35.64  ? 93  PRO A CD   1 
ATOM   2762 N N    . ARG B  1 94  ? 109.139 110.065 99.546  1.00 30.79  ? 94  ARG A N    1 
ATOM   2763 C CA   . ARG B  1 94  ? 108.914 110.875 100.731 1.00 30.60  ? 94  ARG A CA   1 
ATOM   2764 C C    . ARG B  1 94  ? 107.435 110.869 101.093 1.00 42.30  ? 94  ARG A C    1 
ATOM   2765 O O    . ARG B  1 94  ? 106.563 110.622 100.259 1.00 50.70  ? 94  ARG A O    1 
ATOM   2766 C CB   . ARG B  1 94  ? 109.381 112.315 100.510 1.00 29.89  ? 94  ARG A CB   1 
ATOM   2767 C CG   . ARG B  1 94  ? 110.870 112.537 100.663 1.00 28.48  ? 94  ARG A CG   1 
ATOM   2768 C CD   . ARG B  1 94  ? 111.651 111.872 99.555  1.00 29.51  ? 94  ARG A CD   1 
ATOM   2769 N NE   . ARG B  1 94  ? 113.084 112.063 99.725  1.00 32.21  ? 94  ARG A NE   1 
ATOM   2770 C CZ   . ARG B  1 94  ? 113.864 111.263 100.436 1.00 34.20  ? 94  ARG A CZ   1 
ATOM   2771 N NH1  . ARG B  1 94  ? 113.381 110.200 101.056 1.00 29.81  ? 94  ARG A NH1  1 
ATOM   2772 N NH2  . ARG B  1 94  ? 115.161 111.535 100.528 1.00 38.35  ? 94  ARG A NH2  1 
ATOM   2773 N N    . TRP B  1 95  ? 107.160 111.139 102.364 1.00 25.64  ? 95  TRP A N    1 
ATOM   2774 C CA   . TRP B  1 95  ? 105.803 111.371 102.845 1.00 19.71  ? 95  TRP A CA   1 
ATOM   2775 C C    . TRP B  1 95  ? 104.909 110.142 102.733 1.00 24.53  ? 95  TRP A C    1 
ATOM   2776 O O    . TRP B  1 95  ? 103.685 110.259 102.818 1.00 37.45  ? 95  TRP A O    1 
ATOM   2777 C CB   . TRP B  1 95  ? 105.161 112.557 102.123 1.00 12.21  ? 95  TRP A CB   1 
ATOM   2778 C CG   . TRP B  1 95  ? 105.874 113.831 102.395 1.00 18.32  ? 95  TRP A CG   1 
ATOM   2779 C CD1  . TRP B  1 95  ? 106.330 114.728 101.481 1.00 23.16  ? 95  TRP A CD1  1 
ATOM   2780 C CD2  . TRP B  1 95  ? 106.239 114.344 103.679 1.00 21.82  ? 95  TRP A CD2  1 
ATOM   2781 N NE1  . TRP B  1 95  ? 106.947 115.777 102.115 1.00 22.51  ? 95  TRP A NE1  1 
ATOM   2782 C CE2  . TRP B  1 95  ? 106.905 115.562 103.467 1.00 24.10  ? 95  TRP A CE2  1 
ATOM   2783 C CE3  . TRP B  1 95  ? 106.061 113.891 104.988 1.00 17.75  ? 95  TRP A CE3  1 
ATOM   2784 C CZ2  . TRP B  1 95  ? 107.394 116.333 104.513 1.00 22.93  ? 95  TRP A CZ2  1 
ATOM   2785 C CZ3  . TRP B  1 95  ? 106.547 114.657 106.023 1.00 15.79  ? 95  TRP A CZ3  1 
ATOM   2786 C CH2  . TRP B  1 95  ? 107.205 115.864 105.782 1.00 18.56  ? 95  TRP A CH2  1 
ATOM   2787 N N    . ASP B  1 96  ? 105.478 108.959 102.536 1.00 17.27  ? 96  ASP A N    1 
ATOM   2788 C CA   . ASP B  1 96  ? 104.730 107.756 102.856 1.00 16.53  ? 96  ASP A CA   1 
ATOM   2789 C C    . ASP B  1 96  ? 104.827 107.526 104.361 1.00 31.80  ? 96  ASP A C    1 
ATOM   2790 O O    . ASP B  1 96  ? 105.466 108.291 105.086 1.00 30.86  ? 96  ASP A O    1 
ATOM   2791 C CB   . ASP B  1 96  ? 105.242 106.564 102.049 1.00 22.24  ? 96  ASP A CB   1 
ATOM   2792 C CG   . ASP B  1 96  ? 106.678 106.215 102.366 1.00 39.99  ? 96  ASP A CG   1 
ATOM   2793 O OD1  . ASP B  1 96  ? 107.326 106.968 103.120 1.00 42.62  ? 96  ASP A OD1  1 
ATOM   2794 O OD2  . ASP B  1 96  ? 107.163 105.181 101.860 1.00 43.45  ? 96  ASP A OD2  1 
ATOM   2795 N N    . PHE B  1 97  ? 104.185 106.469 104.857 1.00 29.62  ? 97  PHE A N    1 
ATOM   2796 C CA   . PHE B  1 97  ? 104.164 106.281 106.305 1.00 22.96  ? 97  PHE A CA   1 
ATOM   2797 C C    . PHE B  1 97  ? 105.572 106.120 106.861 1.00 26.86  ? 97  PHE A C    1 
ATOM   2798 O O    . PHE B  1 97  ? 105.916 106.724 107.883 1.00 32.00  ? 97  PHE A O    1 
ATOM   2799 C CB   . PHE B  1 97  ? 103.301 105.082 106.683 1.00 22.43  ? 97  PHE A CB   1 
ATOM   2800 C CG   . PHE B  1 97  ? 103.114 104.931 108.162 1.00 27.10  ? 97  PHE A CG   1 
ATOM   2801 C CD1  . PHE B  1 97  ? 102.083 105.580 108.811 1.00 24.71  ? 97  PHE A CD1  1 
ATOM   2802 C CD2  . PHE B  1 97  ? 103.984 104.157 108.908 1.00 27.69  ? 97  PHE A CD2  1 
ATOM   2803 C CE1  . PHE B  1 97  ? 101.917 105.452 110.171 1.00 25.24  ? 97  PHE A CE1  1 
ATOM   2804 C CE2  . PHE B  1 97  ? 103.821 104.027 110.268 1.00 25.11  ? 97  PHE A CE2  1 
ATOM   2805 C CZ   . PHE B  1 97  ? 102.786 104.675 110.900 1.00 26.72  ? 97  PHE A CZ   1 
ATOM   2806 N N    . THR B  1 98  ? 106.407 105.317 106.201 1.00 23.56  ? 98  THR A N    1 
ATOM   2807 C CA   . THR B  1 98  ? 107.769 105.120 106.687 1.00 29.91  ? 98  THR A CA   1 
ATOM   2808 C C    . THR B  1 98  ? 108.597 106.394 106.553 1.00 30.62  ? 98  THR A C    1 
ATOM   2809 O O    . THR B  1 98  ? 109.371 106.738 107.454 1.00 36.71  ? 98  THR A O    1 
ATOM   2810 C CB   . THR B  1 98  ? 108.429 103.968 105.938 1.00 30.31  ? 98  THR A CB   1 
ATOM   2811 O OG1  . THR B  1 98  ? 107.514 102.869 105.856 1.00 24.80  ? 98  THR A OG1  1 
ATOM   2812 C CG2  . THR B  1 98  ? 109.675 103.517 106.671 1.00 36.01  ? 98  THR A CG2  1 
ATOM   2813 N N    . GLY B  1 99  ? 108.452 107.104 105.434 1.00 18.86  ? 99  GLY A N    1 
ATOM   2814 C CA   . GLY B  1 99  ? 109.145 108.373 105.289 1.00 22.28  ? 99  GLY A CA   1 
ATOM   2815 C C    . GLY B  1 99  ? 108.700 109.393 106.316 1.00 25.33  ? 99  GLY A C    1 
ATOM   2816 O O    . GLY B  1 99  ? 109.517 110.139 106.862 1.00 26.33  ? 99  GLY A O    1 
ATOM   2817 N N    . ALA B  1 100 ? 107.397 109.442 106.594 1.00 23.83  ? 100 ALA A N    1 
ATOM   2818 C CA   . ALA B  1 100 ? 106.898 110.342 107.626 1.00 21.71  ? 100 ALA A CA   1 
ATOM   2819 C C    . ALA B  1 100 ? 107.452 109.969 108.995 1.00 22.90  ? 100 ALA A C    1 
ATOM   2820 O O    . ALA B  1 100 ? 107.774 110.847 109.804 1.00 24.60  ? 100 ALA A O    1 
ATOM   2821 C CB   . ALA B  1 100 ? 105.372 110.327 107.641 1.00 22.97  ? 100 ALA A CB   1 
ATOM   2822 N N    . PHE B  1 101 ? 107.557 108.669 109.279 1.00 15.16  ? 101 PHE A N    1 
ATOM   2823 C CA   . PHE B  1 101 ? 108.138 108.237 110.546 1.00 19.69  ? 101 PHE A CA   1 
ATOM   2824 C C    . PHE B  1 101 ? 109.591 108.680 110.658 1.00 21.56  ? 101 PHE A C    1 
ATOM   2825 O O    . PHE B  1 101 ? 110.019 109.181 111.705 1.00 29.57  ? 101 PHE A O    1 
ATOM   2826 C CB   . PHE B  1 101 ? 108.024 106.720 110.678 1.00 18.31  ? 101 PHE A CB   1 
ATOM   2827 C CG   . PHE B  1 101 ? 108.392 106.200 112.035 1.00 25.93  ? 101 PHE A CG   1 
ATOM   2828 C CD1  . PHE B  1 101 ? 107.437 106.084 113.027 1.00 19.98  ? 101 PHE A CD1  1 
ATOM   2829 C CD2  . PHE B  1 101 ? 109.690 105.823 112.319 1.00 23.21  ? 101 PHE A CD2  1 
ATOM   2830 C CE1  . PHE B  1 101 ? 107.771 105.606 114.274 1.00 23.76  ? 101 PHE A CE1  1 
ATOM   2831 C CE2  . PHE B  1 101 ? 110.029 105.344 113.565 1.00 20.95  ? 101 PHE A CE2  1 
ATOM   2832 C CZ   . PHE B  1 101 ? 109.068 105.236 114.543 1.00 27.16  ? 101 PHE A CZ   1 
ATOM   2833 N N    . TYR B  1 102 ? 110.359 108.517 109.582 1.00 12.90  ? 102 TYR A N    1 
ATOM   2834 C CA   . TYR B  1 102 ? 111.744 108.981 109.584 1.00 16.08  ? 102 TYR A CA   1 
ATOM   2835 C C    . TYR B  1 102 ? 111.812 110.487 109.816 1.00 25.20  ? 102 TYR A C    1 
ATOM   2836 O O    . TYR B  1 102 ? 112.646 110.972 110.592 1.00 23.87  ? 102 TYR A O    1 
ATOM   2837 C CB   . TYR B  1 102 ? 112.409 108.604 108.261 1.00 19.98  ? 102 TYR A CB   1 
ATOM   2838 C CG   . TYR B  1 102 ? 113.921 108.567 108.279 1.00 25.77  ? 102 TYR A CG   1 
ATOM   2839 C CD1  . TYR B  1 102 ? 114.646 109.267 109.228 1.00 26.58  ? 102 TYR A CD1  1 
ATOM   2840 C CD2  . TYR B  1 102 ? 114.621 107.830 107.338 1.00 21.63  ? 102 TYR A CD2  1 
ATOM   2841 C CE1  . TYR B  1 102 ? 116.025 109.229 109.241 1.00 27.67  ? 102 TYR A CE1  1 
ATOM   2842 C CE2  . TYR B  1 102 ? 115.996 107.788 107.344 1.00 23.54  ? 102 TYR A CE2  1 
ATOM   2843 C CZ   . TYR B  1 102 ? 116.693 108.488 108.295 1.00 26.45  ? 102 TYR A CZ   1 
ATOM   2844 O OH   . TYR B  1 102 ? 118.065 108.445 108.302 1.00 32.33  ? 102 TYR A OH   1 
ATOM   2845 N N    . PHE B  1 103 ? 110.935 111.242 109.154 1.00 23.13  ? 103 PHE A N    1 
ATOM   2846 C CA   . PHE B  1 103 ? 110.937 112.693 109.300 1.00 17.33  ? 103 PHE A CA   1 
ATOM   2847 C C    . PHE B  1 103 ? 110.628 113.105 110.734 1.00 17.07  ? 103 PHE A C    1 
ATOM   2848 O O    . PHE B  1 103 ? 111.306 113.967 111.304 1.00 23.34  ? 103 PHE A O    1 
ATOM   2849 C CB   . PHE B  1 103 ? 109.931 113.307 108.328 1.00 16.69  ? 103 PHE A CB   1 
ATOM   2850 C CG   . PHE B  1 103 ? 109.677 114.764 108.560 1.00 25.34  ? 103 PHE A CG   1 
ATOM   2851 C CD1  . PHE B  1 103 ? 110.588 115.714 108.143 1.00 21.65  ? 103 PHE A CD1  1 
ATOM   2852 C CD2  . PHE B  1 103 ? 108.521 115.185 109.186 1.00 24.43  ? 103 PHE A CD2  1 
ATOM   2853 C CE1  . PHE B  1 103 ? 110.353 117.052 108.354 1.00 22.09  ? 103 PHE A CE1  1 
ATOM   2854 C CE2  . PHE B  1 103 ? 108.284 116.522 109.398 1.00 22.37  ? 103 PHE A CE2  1 
ATOM   2855 C CZ   . PHE B  1 103 ? 109.200 117.456 108.982 1.00 21.13  ? 103 PHE A CZ   1 
ATOM   2856 N N    . VAL B  1 104 ? 109.607 112.499 111.338 1.00 19.40  ? 104 VAL A N    1 
ATOM   2857 C CA   . VAL B  1 104 ? 109.254 112.861 112.708 1.00 21.17  ? 104 VAL A CA   1 
ATOM   2858 C C    . VAL B  1 104 ? 110.373 112.479 113.664 1.00 19.19  ? 104 VAL A C    1 
ATOM   2859 O O    . VAL B  1 104 ? 110.663 113.204 114.625 1.00 20.03  ? 104 VAL A O    1 
ATOM   2860 C CB   . VAL B  1 104 ? 107.915 112.221 113.111 1.00 17.52  ? 104 VAL A CB   1 
ATOM   2861 C CG1  . VAL B  1 104 ? 106.796 112.759 112.245 1.00 14.26  ? 104 VAL A CG1  1 
ATOM   2862 C CG2  . VAL B  1 104 ? 107.996 110.716 113.001 1.00 12.86  ? 104 VAL A CG2  1 
ATOM   2863 N N    . GLY B  1 105 ? 111.022 111.338 113.424 1.00 28.03  ? 105 GLY A N    1 
ATOM   2864 C CA   . GLY B  1 105 ? 112.159 110.970 114.247 1.00 15.22  ? 105 GLY A CA   1 
ATOM   2865 C C    . GLY B  1 105 ? 113.278 111.988 114.172 1.00 17.24  ? 105 GLY A C    1 
ATOM   2866 O O    . GLY B  1 105 ? 113.879 112.341 115.188 1.00 22.03  ? 105 GLY A O    1 
ATOM   2867 N N    . THR B  1 106 ? 113.573 112.478 112.967 1.00 28.16  ? 106 THR A N    1 
ATOM   2868 C CA   . THR B  1 106 ? 114.600 113.506 112.832 1.00 24.36  ? 106 THR A CA   1 
ATOM   2869 C C    . THR B  1 106 ? 114.149 114.851 113.388 1.00 22.42  ? 106 THR A C    1 
ATOM   2870 O O    . THR B  1 106 ? 114.997 115.698 113.686 1.00 27.82  ? 106 THR A O    1 
ATOM   2871 C CB   . THR B  1 106 ? 115.011 113.675 111.371 1.00 23.83  ? 106 THR A CB   1 
ATOM   2872 O OG1  . THR B  1 106 ? 113.915 114.216 110.625 1.00 25.67  ? 106 THR A OG1  1 
ATOM   2873 C CG2  . THR B  1 106 ? 115.414 112.341 110.776 1.00 20.89  ? 106 THR A CG2  1 
ATOM   2874 N N    . VAL B  1 107 ? 112.843 115.072 113.516 1.00 23.83  ? 107 VAL A N    1 
ATOM   2875 C CA   . VAL B  1 107 ? 112.356 116.350 114.028 1.00 17.34  ? 107 VAL A CA   1 
ATOM   2876 C C    . VAL B  1 107 ? 112.411 116.389 115.550 1.00 17.80  ? 107 VAL A C    1 
ATOM   2877 O O    . VAL B  1 107 ? 112.938 117.339 116.138 1.00 22.55  ? 107 VAL A O    1 
ATOM   2878 C CB   . VAL B  1 107 ? 110.930 116.625 113.516 1.00 17.32  ? 107 VAL A CB   1 
ATOM   2879 C CG1  . VAL B  1 107 ? 110.300 117.754 114.305 1.00 17.46  ? 107 VAL A CG1  1 
ATOM   2880 C CG2  . VAL B  1 107 ? 110.960 116.964 112.042 1.00 15.72  ? 107 VAL A CG2  1 
ATOM   2881 N N    . VAL B  1 108 ? 111.873 115.362 116.213 1.00 26.31  ? 108 VAL A N    1 
ATOM   2882 C CA   . VAL B  1 108 ? 111.793 115.404 117.671 1.00 20.23  ? 108 VAL A CA   1 
ATOM   2883 C C    . VAL B  1 108 ? 113.178 115.433 118.298 1.00 25.00  ? 108 VAL A C    1 
ATOM   2884 O O    . VAL B  1 108 ? 113.382 116.064 119.341 1.00 31.02  ? 108 VAL A O    1 
ATOM   2885 C CB   . VAL B  1 108 ? 110.963 114.223 118.205 1.00 14.78  ? 108 VAL A CB   1 
ATOM   2886 C CG1  . VAL B  1 108 ? 109.527 114.333 117.733 1.00 17.72  ? 108 VAL A CG1  1 
ATOM   2887 C CG2  . VAL B  1 108 ? 111.576 112.909 117.772 1.00 15.97  ? 108 VAL A CG2  1 
ATOM   2888 N N    . SER B  1 109 ? 114.147 114.758 117.689 1.00 28.81  ? 109 SER A N    1 
ATOM   2889 C CA   . SER B  1 109 ? 115.506 114.741 118.213 1.00 18.16  ? 109 SER A CA   1 
ATOM   2890 C C    . SER B  1 109 ? 116.303 115.981 117.831 1.00 25.70  ? 109 SER A C    1 
ATOM   2891 O O    . SER B  1 109 ? 117.452 116.114 118.262 1.00 27.97  ? 109 SER A O    1 
ATOM   2892 C CB   . SER B  1 109 ? 116.240 113.493 117.728 1.00 18.92  ? 109 SER A CB   1 
ATOM   2893 O OG   . SER B  1 109 ? 116.309 113.465 116.316 1.00 18.20  ? 109 SER A OG   1 
ATOM   2894 N N    . THR B  1 110 ? 115.772 116.873 117.015 1.00 26.54  ? 110 THR A N    1 
ATOM   2895 C CA   . THR B  1 110 ? 116.466 118.146 116.694 1.00 21.32  ? 110 THR A CA   1 
ATOM   2896 C C    . THR B  1 110 ? 117.593 117.883 115.691 1.00 19.70  ? 110 THR A C    1 
ATOM   2897 O O    . THR B  1 110 ? 118.407 118.774 115.479 1.00 33.56  ? 110 THR A O    1 
ATOM   2898 C CB   . THR B  1 110 ? 116.871 118.854 117.987 1.00 27.34  ? 110 THR A CB   1 
ATOM   2899 O OG1  . THR B  1 110 ? 115.675 119.078 118.729 1.00 35.57  ? 110 THR A OG1  1 
ATOM   2900 C CG2  . THR B  1 110 ? 117.547 120.191 117.791 1.00 24.15  ? 110 THR A CG2  1 
ATOM   2901 N N    . ILE B  1 111 ? 117.586 116.744 115.019 1.00 8.99   ? 111 ILE A N    1 
ATOM   2902 C CA   . ILE B  1 111 ? 118.652 116.475 114.061 1.00 17.84  ? 111 ILE A CA   1 
ATOM   2903 C C    . ILE B  1 111 ? 118.427 117.267 112.782 1.00 30.87  ? 111 ILE A C    1 
ATOM   2904 O O    . ILE B  1 111 ? 119.314 117.989 112.316 1.00 38.94  ? 111 ILE A O    1 
ATOM   2905 C CB   . ILE B  1 111 ? 118.759 114.967 113.779 1.00 23.80  ? 111 ILE A CB   1 
ATOM   2906 C CG1  . ILE B  1 111 ? 119.092 114.206 115.059 1.00 26.55  ? 111 ILE A CG1  1 
ATOM   2907 C CG2  . ILE B  1 111 ? 119.813 114.703 112.728 1.00 12.47  ? 111 ILE A CG2  1 
ATOM   2908 C CD1  . ILE B  1 111 ? 119.280 112.728 114.849 1.00 22.21  ? 111 ILE A CD1  1 
ATOM   2909 N N    . GLY B  1 112 ? 117.246 117.123 112.205 1.00 18.48  ? 112 GLY A N    1 
ATOM   2910 C CA   . GLY B  1 112 ? 116.892 117.914 111.020 1.00 12.18  ? 112 GLY A CA   1 
ATOM   2911 C C    . GLY B  1 112 ? 117.778 117.728 109.822 1.00 19.34  ? 112 GLY A C    1 
ATOM   2912 O O    . GLY B  1 112 ? 118.334 118.712 109.351 1.00 31.85  ? 112 GLY A O    1 
ATOM   2913 N N    . PHE B  1 113 ? 117.905 116.504 109.345 1.00 24.99  ? 113 PHE A N    1 
ATOM   2914 C CA   . PHE B  1 113 ? 118.684 116.260 108.137 1.00 17.66  ? 113 PHE A CA   1 
ATOM   2915 C C    . PHE B  1 113 ? 118.309 117.167 106.975 1.00 25.90  ? 113 PHE A C    1 
ATOM   2916 O O    . PHE B  1 113 ? 119.184 117.664 106.257 1.00 36.00  ? 113 PHE A O    1 
ATOM   2917 C CB   . PHE B  1 113 ? 118.584 114.793 107.724 1.00 14.56  ? 113 PHE A CB   1 
ATOM   2918 C CG   . PHE B  1 113 ? 119.415 113.870 108.559 1.00 27.90  ? 113 PHE A CG   1 
ATOM   2919 C CD1  . PHE B  1 113 ? 120.678 114.242 108.975 1.00 34.31  ? 113 PHE A CD1  1 
ATOM   2920 C CD2  . PHE B  1 113 ? 118.935 112.629 108.928 1.00 28.00  ? 113 PHE A CD2  1 
ATOM   2921 C CE1  . PHE B  1 113 ? 121.444 113.394 109.741 1.00 30.92  ? 113 PHE A CE1  1 
ATOM   2922 C CE2  . PHE B  1 113 ? 119.698 111.779 109.695 1.00 24.94  ? 113 PHE A CE2  1 
ATOM   2923 C CZ   . PHE B  1 113 ? 120.953 112.162 110.102 1.00 25.26  ? 113 PHE A CZ   1 
ATOM   2924 N N    . GLY B  1 114 ? 117.016 117.400 106.777 1.00 19.41  ? 114 GLY A N    1 
ATOM   2925 C CA   . GLY B  1 114 ? 116.550 118.243 105.701 1.00 21.41  ? 114 GLY A CA   1 
ATOM   2926 C C    . GLY B  1 114 ? 116.238 117.530 104.407 1.00 27.86  ? 114 GLY A C    1 
ATOM   2927 O O    . GLY B  1 114 ? 115.782 118.179 103.458 1.00 33.54  ? 114 GLY A O    1 
ATOM   2928 N N    . MET B  1 115 ? 116.474 116.219 104.328 1.00 29.07  ? 115 MET A N    1 
ATOM   2929 C CA   . MET B  1 115 ? 116.114 115.484 103.122 1.00 24.99  ? 115 MET A CA   1 
ATOM   2930 C C    . MET B  1 115 ? 114.610 115.461 102.898 1.00 30.32  ? 115 MET A C    1 
ATOM   2931 O O    . MET B  1 115 ? 114.167 115.265 101.763 1.00 34.70  ? 115 MET A O    1 
ATOM   2932 C CB   . MET B  1 115 ? 116.653 114.056 103.191 1.00 22.90  ? 115 MET A CB   1 
ATOM   2933 C CG   . MET B  1 115 ? 115.885 113.139 104.125 1.00 31.45  ? 115 MET A CG   1 
ATOM   2934 S SD   . MET B  1 115 ? 115.969 113.631 105.854 1.00 47.03  ? 115 MET A SD   1 
ATOM   2935 C CE   . MET B  1 115 ? 114.956 112.366 106.608 1.00 19.15  ? 115 MET A CE   1 
ATOM   2936 N N    . THR B  1 116 ? 113.821 115.657 103.952 1.00 28.47  ? 116 THR A N    1 
ATOM   2937 C CA   . THR B  1 116 ? 112.368 115.721 103.861 1.00 23.39  ? 116 THR A CA   1 
ATOM   2938 C C    . THR B  1 116 ? 111.894 116.913 104.675 1.00 29.97  ? 116 THR A C    1 
ATOM   2939 O O    . THR B  1 116 ? 112.133 116.973 105.884 1.00 33.59  ? 116 THR A O    1 
ATOM   2940 C CB   . THR B  1 116 ? 111.722 114.433 104.377 1.00 19.22  ? 116 THR A CB   1 
ATOM   2941 O OG1  . THR B  1 116 ? 112.129 113.332 103.557 1.00 33.41  ? 116 THR A OG1  1 
ATOM   2942 C CG2  . THR B  1 116 ? 110.214 114.546 104.344 1.00 14.93  ? 116 THR A CG2  1 
ATOM   2943 N N    . THR B  1 117 ? 111.229 117.857 104.018 1.00 31.45  ? 117 THR A N    1 
ATOM   2944 C CA   . THR B  1 117 ? 110.733 119.049 104.685 1.00 24.92  ? 117 THR A CA   1 
ATOM   2945 C C    . THR B  1 117 ? 109.307 119.340 104.247 1.00 29.47  ? 117 THR A C    1 
ATOM   2946 O O    . THR B  1 117 ? 108.925 119.033 103.114 1.00 30.23  ? 117 THR A O    1 
ATOM   2947 C CB   . THR B  1 117 ? 111.614 120.265 104.376 1.00 25.60  ? 117 THR A CB   1 
ATOM   2948 O OG1  . THR B  1 117 ? 111.619 120.504 102.965 1.00 41.90  ? 117 THR A OG1  1 
ATOM   2949 C CG2  . THR B  1 117 ? 113.036 120.020 104.841 1.00 23.03  ? 117 THR A CG2  1 
ATOM   2950 N N    . PRO B  1 118 ? 108.499 119.933 105.123 1.00 30.29  ? 118 PRO A N    1 
ATOM   2951 C CA   . PRO B  1 118 ? 107.133 120.294 104.735 1.00 24.57  ? 118 PRO A CA   1 
ATOM   2952 C C    . PRO B  1 118 ? 107.140 121.307 103.603 1.00 26.51  ? 118 PRO A C    1 
ATOM   2953 O O    . PRO B  1 118 ? 108.021 122.162 103.511 1.00 33.26  ? 118 PRO A O    1 
ATOM   2954 C CB   . PRO B  1 118 ? 106.543 120.892 106.016 1.00 22.64  ? 118 PRO A CB   1 
ATOM   2955 C CG   . PRO B  1 118 ? 107.407 120.374 107.114 1.00 28.16  ? 118 PRO A CG   1 
ATOM   2956 C CD   . PRO B  1 118 ? 108.775 120.262 106.530 1.00 29.90  ? 118 PRO A CD   1 
ATOM   2957 N N    . ALA B  1 119 ? 106.138 121.204 102.733 1.00 23.73  ? 119 ALA A N    1 
ATOM   2958 C CA   . ALA B  1 119 ? 106.060 122.065 101.565 1.00 26.59  ? 119 ALA A CA   1 
ATOM   2959 C C    . ALA B  1 119 ? 104.719 122.761 101.399 1.00 31.74  ? 119 ALA A C    1 
ATOM   2960 O O    . ALA B  1 119 ? 104.554 123.523 100.442 1.00 38.41  ? 119 ALA A O    1 
ATOM   2961 C CB   . ALA B  1 119 ? 106.369 121.267 100.290 1.00 29.52  ? 119 ALA A CB   1 
ATOM   2962 N N    . THR B  1 120 ? 103.762 122.531 102.292 1.00 29.26  ? 120 THR A N    1 
ATOM   2963 C CA   . THR B  1 120 ? 102.433 123.107 102.173 1.00 27.41  ? 120 THR A CA   1 
ATOM   2964 C C    . THR B  1 120 ? 102.061 123.819 103.463 1.00 34.18  ? 120 THR A C    1 
ATOM   2965 O O    . THR B  1 120 ? 102.537 123.469 104.544 1.00 37.33  ? 120 THR A O    1 
ATOM   2966 C CB   . THR B  1 120 ? 101.380 122.037 101.866 1.00 28.31  ? 120 THR A CB   1 
ATOM   2967 O OG1  . THR B  1 120 ? 101.325 121.100 102.947 1.00 24.42  ? 120 THR A OG1  1 
ATOM   2968 C CG2  . THR B  1 120 ? 101.726 121.302 100.589 1.00 27.24  ? 120 THR A CG2  1 
ATOM   2969 N N    . VAL B  1 121 ? 101.201 124.830 103.337 1.00 35.54  ? 121 VAL A N    1 
ATOM   2970 C CA   . VAL B  1 121 ? 100.635 125.469 104.515 1.00 28.23  ? 121 VAL A CA   1 
ATOM   2971 C C    . VAL B  1 121 ? 99.699  124.485 105.200 1.00 37.25  ? 121 VAL A C    1 
ATOM   2972 O O    . VAL B  1 121 ? 98.805  123.908 104.569 1.00 40.76  ? 121 VAL A O    1 
ATOM   2973 C CB   . VAL B  1 121 ? 99.905  126.763 104.133 1.00 30.47  ? 121 VAL A CB   1 
ATOM   2974 C CG1  . VAL B  1 121 ? 99.275  127.391 105.360 1.00 29.56  ? 121 VAL A CG1  1 
ATOM   2975 C CG2  . VAL B  1 121 ? 100.864 127.731 103.471 1.00 35.84  ? 121 VAL A CG2  1 
ATOM   2976 N N    . GLY B  1 122 ? 99.898  124.294 106.496 1.00 27.83  ? 122 GLY A N    1 
ATOM   2977 C CA   . GLY B  1 122 ? 99.211  123.241 107.213 1.00 23.02  ? 122 GLY A CA   1 
ATOM   2978 C C    . GLY B  1 122 ? 100.207 122.190 107.640 1.00 29.87  ? 122 GLY A C    1 
ATOM   2979 O O    . GLY B  1 122 ? 100.149 121.679 108.761 1.00 40.21  ? 122 GLY A O    1 
ATOM   2980 N N    . GLY B  1 123 ? 101.136 121.866 106.746 1.00 22.51  ? 123 GLY A N    1 
ATOM   2981 C CA   . GLY B  1 123 ? 102.269 121.046 107.113 1.00 21.40  ? 123 GLY A CA   1 
ATOM   2982 C C    . GLY B  1 123 ? 103.364 121.787 107.837 1.00 24.80  ? 123 GLY A C    1 
ATOM   2983 O O    . GLY B  1 123 ? 104.262 121.154 108.397 1.00 30.26  ? 123 GLY A O    1 
ATOM   2984 N N    . LYS B  1 124 ? 103.307 123.117 107.839 1.00 27.57  ? 124 LYS A N    1 
ATOM   2985 C CA   . LYS B  1 124 ? 104.255 123.955 108.560 1.00 23.86  ? 124 LYS A CA   1 
ATOM   2986 C C    . LYS B  1 124 ? 103.735 124.400 109.918 1.00 28.65  ? 124 LYS A C    1 
ATOM   2987 O O    . LYS B  1 124 ? 104.505 124.461 110.879 1.00 30.37  ? 124 LYS A O    1 
ATOM   2988 C CB   . LYS B  1 124 ? 104.616 125.184 107.720 1.00 24.25  ? 124 LYS A CB   1 
ATOM   2989 C CG   . LYS B  1 124 ? 105.276 124.845 106.397 1.00 20.79  ? 124 LYS A CG   1 
ATOM   2990 C CD   . LYS B  1 124 ? 105.682 126.092 105.638 1.00 19.98  ? 124 LYS A CD   1 
ATOM   2991 C CE   . LYS B  1 124 ? 106.422 125.739 104.364 1.00 21.95  ? 124 LYS A CE   1 
ATOM   2992 N NZ   . LYS B  1 124 ? 106.813 126.946 103.592 1.00 25.92  ? 124 LYS A NZ   1 
ATOM   2993 N N    . ILE B  1 125 ? 102.443 124.718 110.022 1.00 25.61  ? 125 ILE A N    1 
ATOM   2994 C CA   . ILE B  1 125 ? 101.855 125.019 111.324 1.00 25.74  ? 125 ILE A CA   1 
ATOM   2995 C C    . ILE B  1 125 ? 101.920 123.792 112.223 1.00 29.88  ? 125 ILE A C    1 
ATOM   2996 O O    . ILE B  1 125 ? 102.383 123.854 113.375 1.00 32.99  ? 125 ILE A O    1 
ATOM   2997 C CB   . ILE B  1 125 ? 100.407 125.506 111.152 1.00 20.37  ? 125 ILE A CB   1 
ATOM   2998 C CG1  . ILE B  1 125 ? 100.327 126.568 110.057 1.00 19.41  ? 125 ILE A CG1  1 
ATOM   2999 C CG2  . ILE B  1 125 ? 99.871  126.047 112.459 1.00 28.78  ? 125 ILE A CG2  1 
ATOM   3000 C CD1  . ILE B  1 125 ? 98.915  126.962 109.705 1.00 22.09  ? 125 ILE A CD1  1 
ATOM   3001 N N    . PHE B  1 126 ? 101.461 122.654 111.703 1.00 25.21  ? 126 PHE A N    1 
ATOM   3002 C CA   . PHE B  1 126 ? 101.517 121.427 112.480 1.00 21.09  ? 126 PHE A CA   1 
ATOM   3003 C C    . PHE B  1 126 ? 102.947 121.073 112.838 1.00 19.21  ? 126 PHE A C    1 
ATOM   3004 O O    . PHE B  1 126 ? 103.193 120.535 113.916 1.00 28.26  ? 126 PHE A O    1 
ATOM   3005 C CB   . PHE B  1 126 ? 100.861 120.277 111.721 1.00 21.01  ? 126 PHE A CB   1 
ATOM   3006 C CG   . PHE B  1 126 ? 100.791 119.004 112.508 1.00 27.82  ? 126 PHE A CG   1 
ATOM   3007 C CD1  . PHE B  1 126 ? 99.902  118.875 113.557 1.00 25.73  ? 126 PHE A CD1  1 
ATOM   3008 C CD2  . PHE B  1 126 ? 101.618 117.941 112.205 1.00 26.14  ? 126 PHE A CD2  1 
ATOM   3009 C CE1  . PHE B  1 126 ? 99.838  117.709 114.286 1.00 22.60  ? 126 PHE A CE1  1 
ATOM   3010 C CE2  . PHE B  1 126 ? 101.556 116.773 112.931 1.00 19.92  ? 126 PHE A CE2  1 
ATOM   3011 C CZ   . PHE B  1 126 ? 100.665 116.657 113.972 1.00 25.75  ? 126 PHE A CZ   1 
ATOM   3012 N N    . LEU B  1 127 ? 103.903 121.366 111.957 1.00 15.57  ? 127 LEU A N    1 
ATOM   3013 C CA   . LEU B  1 127 ? 105.299 121.136 112.307 1.00 22.29  ? 127 LEU A CA   1 
ATOM   3014 C C    . LEU B  1 127 ? 105.696 121.964 113.519 1.00 24.92  ? 127 LEU A C    1 
ATOM   3015 O O    . LEU B  1 127 ? 106.367 121.465 114.429 1.00 28.28  ? 127 LEU A O    1 
ATOM   3016 C CB   . LEU B  1 127 ? 106.203 121.453 111.118 1.00 23.88  ? 127 LEU A CB   1 
ATOM   3017 C CG   . LEU B  1 127 ? 107.712 121.295 111.325 1.00 22.78  ? 127 LEU A CG   1 
ATOM   3018 C CD1  . LEU B  1 127 ? 108.316 122.537 111.954 1.00 18.56  ? 127 LEU A CD1  1 
ATOM   3019 C CD2  . LEU B  1 127 ? 107.998 120.079 112.180 1.00 23.13  ? 127 LEU A CD2  1 
ATOM   3020 N N    . ILE B  1 128 ? 105.277 123.229 113.556 1.00 25.51  ? 128 ILE A N    1 
ATOM   3021 C CA   . ILE B  1 128 ? 105.624 124.092 114.681 1.00 25.41  ? 128 ILE A CA   1 
ATOM   3022 C C    . ILE B  1 128 ? 105.061 123.526 115.975 1.00 27.40  ? 128 ILE A C    1 
ATOM   3023 O O    . ILE B  1 128 ? 105.784 123.355 116.965 1.00 28.76  ? 128 ILE A O    1 
ATOM   3024 C CB   . ILE B  1 128 ? 105.122 125.526 114.431 1.00 25.20  ? 128 ILE A CB   1 
ATOM   3025 C CG1  . ILE B  1 128 ? 105.922 126.186 113.308 1.00 23.60  ? 128 ILE A CG1  1 
ATOM   3026 C CG2  . ILE B  1 128 ? 105.206 126.345 115.702 1.00 21.67  ? 128 ILE A CG2  1 
ATOM   3027 C CD1  . ILE B  1 128 ? 105.476 127.591 112.990 1.00 18.26  ? 128 ILE A CD1  1 
ATOM   3028 N N    . PHE B  1 129 ? 103.764 123.209 115.986 1.00 26.94  ? 129 PHE A N    1 
ATOM   3029 C CA   . PHE B  1 129 ? 103.162 122.707 117.221 1.00 22.80  ? 129 PHE A CA   1 
ATOM   3030 C C    . PHE B  1 129 ? 103.746 121.355 117.620 1.00 25.86  ? 129 PHE A C    1 
ATOM   3031 O O    . PHE B  1 129 ? 104.017 121.109 118.804 1.00 28.41  ? 129 PHE A O    1 
ATOM   3032 C CB   . PHE B  1 129 ? 101.646 122.622 117.067 1.00 18.88  ? 129 PHE A CB   1 
ATOM   3033 C CG   . PHE B  1 129 ? 100.973 123.959 117.049 1.00 25.01  ? 129 PHE A CG   1 
ATOM   3034 C CD1  . PHE B  1 129 ? 100.629 124.590 118.229 1.00 29.39  ? 129 PHE A CD1  1 
ATOM   3035 C CD2  . PHE B  1 129 ? 100.698 124.593 115.853 1.00 27.66  ? 129 PHE A CD2  1 
ATOM   3036 C CE1  . PHE B  1 129 ? 100.015 125.823 118.217 1.00 32.84  ? 129 PHE A CE1  1 
ATOM   3037 C CE2  . PHE B  1 129 ? 100.084 125.829 115.835 1.00 31.00  ? 129 PHE A CE2  1 
ATOM   3038 C CZ   . PHE B  1 129 ? 99.742  126.443 117.018 1.00 33.24  ? 129 PHE A CZ   1 
ATOM   3039 N N    . TYR B  1 130 ? 103.950 120.471 116.645 1.00 21.77  ? 130 TYR A N    1 
ATOM   3040 C CA   . TYR B  1 130 ? 104.495 119.150 116.919 1.00 19.43  ? 130 TYR A CA   1 
ATOM   3041 C C    . TYR B  1 130 ? 105.878 119.250 117.543 1.00 26.09  ? 130 TYR A C    1 
ATOM   3042 O O    . TYR B  1 130 ? 106.155 118.613 118.564 1.00 26.95  ? 130 TYR A O    1 
ATOM   3043 C CB   . TYR B  1 130 ? 104.538 118.349 115.618 1.00 9.99   ? 130 TYR A CB   1 
ATOM   3044 C CG   . TYR B  1 130 ? 104.828 116.881 115.778 1.00 21.26  ? 130 TYR A CG   1 
ATOM   3045 C CD1  . TYR B  1 130 ? 103.804 115.974 115.993 1.00 21.84  ? 130 TYR A CD1  1 
ATOM   3046 C CD2  . TYR B  1 130 ? 106.122 116.397 115.689 1.00 19.42  ? 130 TYR A CD2  1 
ATOM   3047 C CE1  . TYR B  1 130 ? 104.062 114.633 116.130 1.00 15.51  ? 130 TYR A CE1  1 
ATOM   3048 C CE2  . TYR B  1 130 ? 106.388 115.057 115.827 1.00 21.08  ? 130 TYR A CE2  1 
ATOM   3049 C CZ   . TYR B  1 130 ? 105.354 114.180 116.046 1.00 19.29  ? 130 TYR A CZ   1 
ATOM   3050 O OH   . TYR B  1 130 ? 105.615 112.840 116.183 1.00 29.98  ? 130 TYR A OH   1 
ATOM   3051 N N    . GLY B  1 131 ? 106.760 120.053 116.949 1.00 21.42  ? 131 GLY A N    1 
ATOM   3052 C CA   . GLY B  1 131 ? 108.079 120.225 117.526 1.00 18.87  ? 131 GLY A CA   1 
ATOM   3053 C C    . GLY B  1 131 ? 108.026 120.846 118.907 1.00 21.64  ? 131 GLY A C    1 
ATOM   3054 O O    . GLY B  1 131 ? 108.717 120.398 119.826 1.00 27.36  ? 131 GLY A O    1 
ATOM   3055 N N    . LEU B  1 132 ? 107.178 121.864 119.077 1.00 22.76  ? 132 LEU A N    1 
ATOM   3056 C CA   . LEU B  1 132 ? 107.078 122.545 120.361 1.00 23.20  ? 132 LEU A CA   1 
ATOM   3057 C C    . LEU B  1 132 ? 106.676 121.581 121.468 1.00 22.79  ? 132 LEU A C    1 
ATOM   3058 O O    . LEU B  1 132 ? 107.183 121.669 122.592 1.00 28.48  ? 132 LEU A O    1 
ATOM   3059 C CB   . LEU B  1 132 ? 106.078 123.693 120.259 1.00 26.60  ? 132 LEU A CB   1 
ATOM   3060 C CG   . LEU B  1 132 ? 105.906 124.583 121.486 1.00 28.79  ? 132 LEU A CG   1 
ATOM   3061 C CD1  . LEU B  1 132 ? 107.203 125.300 121.802 1.00 28.90  ? 132 LEU A CD1  1 
ATOM   3062 C CD2  . LEU B  1 132 ? 104.785 125.576 121.255 1.00 27.69  ? 132 LEU A CD2  1 
ATOM   3063 N N    . VAL B  1 133 ? 105.760 120.659 121.177 1.00 30.13  ? 133 VAL A N    1 
ATOM   3064 C CA   . VAL B  1 133 ? 105.333 119.711 122.203 1.00 28.01  ? 133 VAL A CA   1 
ATOM   3065 C C    . VAL B  1 133 ? 106.207 118.462 122.278 1.00 26.36  ? 133 VAL A C    1 
ATOM   3066 O O    . VAL B  1 133 ? 106.125 117.723 123.268 1.00 23.84  ? 133 VAL A O    1 
ATOM   3067 C CB   . VAL B  1 133 ? 103.867 119.297 121.990 1.00 27.28  ? 133 VAL A CB   1 
ATOM   3068 C CG1  . VAL B  1 133 ? 103.412 118.375 123.105 1.00 18.55  ? 133 VAL A CG1  1 
ATOM   3069 C CG2  . VAL B  1 133 ? 102.979 120.525 121.922 1.00 23.85  ? 133 VAL A CG2  1 
ATOM   3070 N N    . GLY B  1 134 ? 107.045 118.208 121.275 1.00 26.12  ? 134 GLY A N    1 
ATOM   3071 C CA   . GLY B  1 134 ? 107.806 116.973 121.251 1.00 16.71  ? 134 GLY A CA   1 
ATOM   3072 C C    . GLY B  1 134 ? 109.259 117.066 121.664 1.00 22.47  ? 134 GLY A C    1 
ATOM   3073 O O    . GLY B  1 134 ? 109.785 116.121 122.259 1.00 26.89  ? 134 GLY A O    1 
ATOM   3074 N N    . CYS B  1 135 ? 109.934 118.171 121.349 1.00 22.14  ? 135 CYS A N    1 
ATOM   3075 C CA   . CYS B  1 135 ? 111.346 118.285 121.712 1.00 17.69  ? 135 CYS A CA   1 
ATOM   3076 C C    . CYS B  1 135 ? 111.569 118.211 123.218 1.00 25.67  ? 135 CYS A C    1 
ATOM   3077 O O    . CYS B  1 135 ? 112.479 117.481 123.656 1.00 34.64  ? 135 CYS A O    1 
ATOM   3078 C CB   . CYS B  1 135 ? 111.923 119.575 121.124 1.00 27.87  ? 135 CYS A CB   1 
ATOM   3079 S SG   . CYS B  1 135 ? 111.877 119.649 119.321 1.00 32.82  ? 135 CYS A SG   1 
ATOM   3080 N N    . PRO B  1 136 ? 110.808 118.923 124.054 1.00 23.64  ? 136 PRO A N    1 
ATOM   3081 C CA   . PRO B  1 136 ? 111.008 118.789 125.504 1.00 15.58  ? 136 PRO A CA   1 
ATOM   3082 C C    . PRO B  1 136 ? 110.862 117.362 125.998 1.00 21.62  ? 136 PRO A C    1 
ATOM   3083 O O    . PRO B  1 136 ? 111.573 116.954 126.925 1.00 31.89  ? 136 PRO A O    1 
ATOM   3084 C CB   . PRO B  1 136 ? 109.923 119.705 126.084 1.00 22.63  ? 136 PRO A CB   1 
ATOM   3085 C CG   . PRO B  1 136 ? 109.653 120.691 125.012 1.00 20.36  ? 136 PRO A CG   1 
ATOM   3086 C CD   . PRO B  1 136 ? 109.810 119.952 123.725 1.00 17.05  ? 136 PRO A CD   1 
ATOM   3087 N N    . SER B  1 137 ? 109.950 116.589 125.407 1.00 13.63  ? 137 SER A N    1 
ATOM   3088 C CA   . SER B  1 137 ? 109.789 115.201 125.823 1.00 12.50  ? 137 SER A CA   1 
ATOM   3089 C C    . SER B  1 137 ? 111.059 114.402 125.569 1.00 20.16  ? 137 SER A C    1 
ATOM   3090 O O    . SER B  1 137 ? 111.488 113.614 126.420 1.00 37.09  ? 137 SER A O    1 
ATOM   3091 C CB   . SER B  1 137 ? 108.605 114.573 125.093 1.00 22.10  ? 137 SER A CB   1 
ATOM   3092 O OG   . SER B  1 137 ? 107.437 115.353 125.260 1.00 31.04  ? 137 SER A OG   1 
ATOM   3093 N N    . THR B  1 138 ? 111.679 114.592 124.405 1.00 17.93  ? 138 THR A N    1 
ATOM   3094 C CA   . THR B  1 138 ? 112.920 113.886 124.111 1.00 22.16  ? 138 THR A CA   1 
ATOM   3095 C C    . THR B  1 138 ? 114.042 114.328 125.041 1.00 22.66  ? 138 THR A C    1 
ATOM   3096 O O    . THR B  1 138 ? 114.853 113.503 125.482 1.00 30.08  ? 138 THR A O    1 
ATOM   3097 C CB   . THR B  1 138 ? 113.312 114.099 122.652 1.00 23.23  ? 138 THR A CB   1 
ATOM   3098 O OG1  . THR B  1 138 ? 112.266 113.612 121.805 1.00 24.43  ? 138 THR A OG1  1 
ATOM   3099 C CG2  . THR B  1 138 ? 114.590 113.352 122.334 1.00 22.69  ? 138 THR A CG2  1 
ATOM   3100 N N    . ILE B  1 139 ? 114.113 115.624 125.351 1.00 17.19  ? 139 ILE A N    1 
ATOM   3101 C CA   . ILE B  1 139 ? 115.132 116.086 126.291 1.00 23.47  ? 139 ILE A CA   1 
ATOM   3102 C C    . ILE B  1 139 ? 114.943 115.421 127.651 1.00 28.31  ? 139 ILE A C    1 
ATOM   3103 O O    . ILE B  1 139 ? 115.906 114.960 128.282 1.00 33.10  ? 139 ILE A O    1 
ATOM   3104 C CB   . ILE B  1 139 ? 115.104 117.620 126.401 1.00 24.78  ? 139 ILE A CB   1 
ATOM   3105 C CG1  . ILE B  1 139 ? 115.474 118.254 125.061 1.00 23.36  ? 139 ILE A CG1  1 
ATOM   3106 C CG2  . ILE B  1 139 ? 116.046 118.091 127.490 1.00 25.89  ? 139 ILE A CG2  1 
ATOM   3107 C CD1  . ILE B  1 139 ? 115.473 119.759 125.085 1.00 22.00  ? 139 ILE A CD1  1 
ATOM   3108 N N    . LEU B  1 140 ? 113.696 115.360 128.123 1.00 17.90  ? 140 LEU A N    1 
ATOM   3109 C CA   . LEU B  1 140 ? 113.421 114.711 129.399 1.00 18.66  ? 140 LEU A CA   1 
ATOM   3110 C C    . LEU B  1 140 ? 113.789 113.235 129.353 1.00 27.94  ? 140 LEU A C    1 
ATOM   3111 O O    . LEU B  1 140 ? 114.317 112.686 130.327 1.00 35.35  ? 140 LEU A O    1 
ATOM   3112 C CB   . LEU B  1 140 ? 111.949 114.886 129.765 1.00 14.80  ? 140 LEU A CB   1 
ATOM   3113 C CG   . LEU B  1 140 ? 111.505 114.279 131.091 1.00 17.74  ? 140 LEU A CG   1 
ATOM   3114 C CD1  . LEU B  1 140 ? 112.239 114.935 132.242 1.00 17.54  ? 140 LEU A CD1  1 
ATOM   3115 C CD2  . LEU B  1 140 ? 110.008 114.421 131.257 1.00 19.72  ? 140 LEU A CD2  1 
ATOM   3116 N N    . PHE B  1 141 ? 113.505 112.573 128.232 1.00 25.67  ? 141 PHE A N    1 
ATOM   3117 C CA   . PHE B  1 141 ? 113.864 111.167 128.092 1.00 21.35  ? 141 PHE A CA   1 
ATOM   3118 C C    . PHE B  1 141 ? 115.371 110.974 128.196 1.00 27.79  ? 141 PHE A C    1 
ATOM   3119 O O    . PHE B  1 141 ? 115.844 110.049 128.865 1.00 29.57  ? 141 PHE A O    1 
ATOM   3120 C CB   . PHE B  1 141 ? 113.339 110.628 126.763 1.00 20.19  ? 141 PHE A CB   1 
ATOM   3121 C CG   . PHE B  1 141 ? 113.610 109.170 126.547 1.00 30.63  ? 141 PHE A CG   1 
ATOM   3122 C CD1  . PHE B  1 141 ? 112.807 108.209 127.130 1.00 25.06  ? 141 PHE A CD1  1 
ATOM   3123 C CD2  . PHE B  1 141 ? 114.662 108.760 125.750 1.00 30.49  ? 141 PHE A CD2  1 
ATOM   3124 C CE1  . PHE B  1 141 ? 113.053 106.869 126.930 1.00 20.35  ? 141 PHE A CE1  1 
ATOM   3125 C CE2  . PHE B  1 141 ? 114.911 107.421 125.546 1.00 26.73  ? 141 PHE A CE2  1 
ATOM   3126 C CZ   . PHE B  1 141 ? 114.106 106.476 126.137 1.00 24.20  ? 141 PHE A CZ   1 
ATOM   3127 N N    . PHE B  1 142 ? 116.142 111.844 127.543 1.00 28.66  ? 142 PHE A N    1 
ATOM   3128 C CA   . PHE B  1 142 ? 117.596 111.737 127.627 1.00 24.18  ? 142 PHE A CA   1 
ATOM   3129 C C    . PHE B  1 142 ? 118.085 111.943 129.056 1.00 31.80  ? 142 PHE A C    1 
ATOM   3130 O O    . PHE B  1 142 ? 118.975 111.224 129.529 1.00 37.73  ? 142 PHE A O    1 
ATOM   3131 C CB   . PHE B  1 142 ? 118.253 112.741 126.682 1.00 27.05  ? 142 PHE A CB   1 
ATOM   3132 C CG   . PHE B  1 142 ? 118.019 112.446 125.229 1.00 26.49  ? 142 PHE A CG   1 
ATOM   3133 C CD1  . PHE B  1 142 ? 117.719 111.164 124.810 1.00 29.14  ? 142 PHE A CD1  1 
ATOM   3134 C CD2  . PHE B  1 142 ? 118.099 113.451 124.284 1.00 27.49  ? 142 PHE A CD2  1 
ATOM   3135 C CE1  . PHE B  1 142 ? 117.503 110.892 123.477 1.00 30.27  ? 142 PHE A CE1  1 
ATOM   3136 C CE2  . PHE B  1 142 ? 117.884 113.183 122.950 1.00 27.87  ? 142 PHE A CE2  1 
ATOM   3137 C CZ   . PHE B  1 142 ? 117.587 111.902 122.546 1.00 28.72  ? 142 PHE A CZ   1 
ATOM   3138 N N    . ASN B  1 143 ? 117.519 112.925 129.762 1.00 32.31  ? 143 ASN A N    1 
ATOM   3139 C CA   . ASN B  1 143 ? 117.929 113.150 131.147 1.00 24.82  ? 143 ASN A CA   1 
ATOM   3140 C C    . ASN B  1 143 ? 117.615 111.941 132.023 1.00 30.13  ? 143 ASN A C    1 
ATOM   3141 O O    . ASN B  1 143 ? 118.436 111.532 132.857 1.00 42.48  ? 143 ASN A O    1 
ATOM   3142 C CB   . ASN B  1 143 ? 117.253 114.401 131.701 1.00 25.33  ? 143 ASN A CB   1 
ATOM   3143 C CG   . ASN B  1 143 ? 117.714 115.663 131.010 1.00 37.52  ? 143 ASN A CG   1 
ATOM   3144 O OD1  . ASN B  1 143 ? 118.796 115.705 130.429 1.00 43.89  ? 143 ASN A OD1  1 
ATOM   3145 N ND2  . ASN B  1 143 ? 116.894 116.702 131.072 1.00 36.09  ? 143 ASN A ND2  1 
ATOM   3146 N N    . LEU B  1 144 ? 116.427 111.358 131.853 1.00 26.28  ? 144 LEU A N    1 
ATOM   3147 C CA   . LEU B  1 144 ? 116.073 110.176 132.631 1.00 26.41  ? 144 LEU A CA   1 
ATOM   3148 C C    . LEU B  1 144 ? 117.013 109.019 132.321 1.00 30.50  ? 144 LEU A C    1 
ATOM   3149 O O    . LEU B  1 144 ? 117.412 108.271 133.223 1.00 38.61  ? 144 LEU A O    1 
ATOM   3150 C CB   . LEU B  1 144 ? 114.624 109.780 132.357 1.00 29.73  ? 144 LEU A CB   1 
ATOM   3151 C CG   . LEU B  1 144 ? 113.562 110.808 132.736 1.00 21.73  ? 144 LEU A CG   1 
ATOM   3152 C CD1  . LEU B  1 144 ? 112.176 110.251 132.487 1.00 21.96  ? 144 LEU A CD1  1 
ATOM   3153 C CD2  . LEU B  1 144 ? 113.719 111.222 134.183 1.00 29.05  ? 144 LEU A CD2  1 
ATOM   3154 N N    . PHE B  1 145 ? 117.376 108.853 131.048 1.00 31.59  ? 145 PHE A N    1 
ATOM   3155 C CA   . PHE B  1 145 ? 118.329 107.808 130.692 1.00 32.20  ? 145 PHE A CA   1 
ATOM   3156 C C    . PHE B  1 145 ? 119.665 108.026 131.386 1.00 32.40  ? 145 PHE A C    1 
ATOM   3157 O O    . PHE B  1 145 ? 120.275 107.074 131.884 1.00 39.20  ? 145 PHE A O    1 
ATOM   3158 C CB   . PHE B  1 145 ? 118.523 107.756 129.179 1.00 32.45  ? 145 PHE A CB   1 
ATOM   3159 C CG   . PHE B  1 145 ? 119.794 107.076 128.762 1.00 38.08  ? 145 PHE A CG   1 
ATOM   3160 C CD1  . PHE B  1 145 ? 119.859 105.699 128.670 1.00 36.94  ? 145 PHE A CD1  1 
ATOM   3161 C CD2  . PHE B  1 145 ? 120.926 107.815 128.469 1.00 34.76  ? 145 PHE A CD2  1 
ATOM   3162 C CE1  . PHE B  1 145 ? 121.028 105.073 128.293 1.00 35.15  ? 145 PHE A CE1  1 
ATOM   3163 C CE2  . PHE B  1 145 ? 122.096 107.193 128.090 1.00 32.83  ? 145 PHE A CE2  1 
ATOM   3164 C CZ   . PHE B  1 145 ? 122.146 105.821 128.002 1.00 34.73  ? 145 PHE A CZ   1 
ATOM   3165 N N    . LEU B  1 146 ? 120.145 109.269 131.412 1.00 30.70  ? 146 LEU A N    1 
ATOM   3166 C CA   . LEU B  1 146 ? 121.417 109.539 132.078 1.00 32.47  ? 146 LEU A CA   1 
ATOM   3167 C C    . LEU B  1 146 ? 121.343 109.198 133.561 1.00 36.87  ? 146 LEU A C    1 
ATOM   3168 O O    . LEU B  1 146 ? 122.272 108.598 134.118 1.00 44.41  ? 146 LEU A O    1 
ATOM   3169 C CB   . LEU B  1 146 ? 121.817 110.999 131.885 1.00 34.39  ? 146 LEU A CB   1 
ATOM   3170 C CG   . LEU B  1 146 ? 123.107 111.410 132.591 1.00 38.26  ? 146 LEU A CG   1 
ATOM   3171 C CD1  . LEU B  1 146 ? 124.248 110.502 132.176 1.00 33.54  ? 146 LEU A CD1  1 
ATOM   3172 C CD2  . LEU B  1 146 ? 123.442 112.859 132.292 1.00 36.44  ? 146 LEU A CD2  1 
ATOM   3173 N N    . GLU B  1 147 ? 120.245 109.575 134.218 1.00 40.11  ? 147 GLU A N    1 
ATOM   3174 C CA   . GLU B  1 147 ? 120.099 109.243 135.632 1.00 36.39  ? 147 GLU A CA   1 
ATOM   3175 C C    . GLU B  1 147 ? 120.103 107.734 135.850 1.00 40.23  ? 147 GLU A C    1 
ATOM   3176 O O    . GLU B  1 147 ? 120.758 107.229 136.772 1.00 47.25  ? 147 GLU A O    1 
ATOM   3177 C CB   . GLU B  1 147 ? 118.817 109.853 136.189 1.00 41.15  ? 147 GLU A CB   1 
ATOM   3178 C CG   . GLU B  1 147 ? 118.444 109.317 137.555 1.00 48.75  ? 147 GLU A CG   1 
ATOM   3179 C CD   . GLU B  1 147 ? 117.074 109.772 138.007 1.00 59.35  ? 147 GLU A CD   1 
ATOM   3180 O OE1  . GLU B  1 147 ? 116.502 110.675 137.361 1.00 59.80  ? 147 GLU A OE1  1 
ATOM   3181 O OE2  . GLU B  1 147 ? 116.566 109.223 139.006 1.00 55.40  ? 147 GLU A OE2  1 
ATOM   3182 N N    . ARG B  1 148 ? 119.370 106.998 135.011 1.00 42.79  ? 148 ARG A N    1 
ATOM   3183 C CA   . ARG B  1 148 ? 119.340 105.546 135.145 1.00 40.88  ? 148 ARG A CA   1 
ATOM   3184 C C    . ARG B  1 148 ? 120.728 104.950 134.953 1.00 43.14  ? 148 ARG A C    1 
ATOM   3185 O O    . ARG B  1 148 ? 121.121 104.023 135.672 1.00 40.58  ? 148 ARG A O    1 
ATOM   3186 C CB   . ARG B  1 148 ? 118.359 104.946 134.139 1.00 34.14  ? 148 ARG A CB   1 
ATOM   3187 C CG   . ARG B  1 148 ? 116.899 105.266 134.405 1.00 29.23  ? 148 ARG A CG   1 
ATOM   3188 C CD   . ARG B  1 148 ? 116.360 104.472 135.577 1.00 33.03  ? 148 ARG A CD   1 
ATOM   3189 N NE   . ARG B  1 148 ? 116.814 105.000 136.856 1.00 41.95  ? 148 ARG A NE   1 
ATOM   3190 C CZ   . ARG B  1 148 ? 116.587 104.421 138.025 1.00 36.84  ? 148 ARG A CZ   1 
ATOM   3191 N NH1  . ARG B  1 148 ? 115.929 103.279 138.114 1.00 38.14  ? 148 ARG A NH1  1 
ATOM   3192 N NH2  . ARG B  1 148 ? 117.032 105.002 139.135 1.00 36.22  ? 148 ARG A NH2  1 
ATOM   3193 N N    . LEU B  1 149 ? 121.479 105.461 133.978 1.00 47.66  ? 149 LEU A N    1 
ATOM   3194 C CA   . LEU B  1 149 ? 122.826 104.954 133.740 1.00 41.96  ? 149 LEU A CA   1 
ATOM   3195 C C    . LEU B  1 149 ? 123.724 105.192 134.945 1.00 38.91  ? 149 LEU A C    1 
ATOM   3196 O O    . LEU B  1 149 ? 124.499 104.311 135.337 1.00 42.13  ? 149 LEU A O    1 
ATOM   3197 C CB   . LEU B  1 149 ? 123.420 105.608 132.495 1.00 38.73  ? 149 LEU A CB   1 
ATOM   3198 C CG   . LEU B  1 149 ? 124.862 105.226 132.176 1.00 37.58  ? 149 LEU A CG   1 
ATOM   3199 C CD1  . LEU B  1 149 ? 124.957 103.748 131.856 1.00 40.78  ? 149 LEU A CD1  1 
ATOM   3200 C CD2  . LEU B  1 149 ? 125.390 106.061 131.027 1.00 38.92  ? 149 LEU A CD2  1 
ATOM   3201 N N    . ILE B  1 150 ? 123.642 106.382 135.542 1.00 38.77  ? 150 ILE A N    1 
ATOM   3202 C CA   . ILE B  1 150 ? 124.461 106.657 136.720 1.00 38.87  ? 150 ILE A CA   1 
ATOM   3203 C C    . ILE B  1 150 ? 124.096 105.709 137.854 1.00 43.38  ? 150 ILE A C    1 
ATOM   3204 O O    . ILE B  1 150 ? 124.973 105.168 138.543 1.00 47.46  ? 150 ILE A O    1 
ATOM   3205 C CB   . ILE B  1 150 ? 124.317 108.129 137.144 1.00 39.71  ? 150 ILE A CB   1 
ATOM   3206 C CG1  . ILE B  1 150 ? 124.938 109.046 136.093 1.00 38.95  ? 150 ILE A CG1  1 
ATOM   3207 C CG2  . ILE B  1 150 ? 124.963 108.354 138.494 1.00 39.89  ? 150 ILE A CG2  1 
ATOM   3208 C CD1  . ILE B  1 150 ? 124.853 110.508 136.444 1.00 40.21  ? 150 ILE A CD1  1 
ATOM   3209 N N    . THR B  1 151 ? 122.796 105.491 138.067 1.00 50.03  ? 151 THR A N    1 
ATOM   3210 C CA   . THR B  1 151 ? 122.378 104.582 139.130 1.00 48.87  ? 151 THR A CA   1 
ATOM   3211 C C    . THR B  1 151 ? 122.899 103.172 138.888 1.00 50.14  ? 151 THR A C    1 
ATOM   3212 O O    . THR B  1 151 ? 123.373 102.508 139.818 1.00 53.34  ? 151 THR A O    1 
ATOM   3213 C CB   . THR B  1 151 ? 120.858 104.569 139.250 1.00 48.89  ? 151 THR A CB   1 
ATOM   3214 O OG1  . THR B  1 151 ? 120.400 105.862 139.665 1.00 54.33  ? 151 THR A OG1  1 
ATOM   3215 C CG2  . THR B  1 151 ? 120.421 103.534 140.268 1.00 45.80  ? 151 THR A CG2  1 
ATOM   3216 N N    . ILE B  1 152 ? 122.819 102.695 137.645 1.00 52.68  ? 152 ILE A N    1 
ATOM   3217 C CA   . ILE B  1 152 ? 123.268 101.337 137.356 1.00 47.24  ? 152 ILE A CA   1 
ATOM   3218 C C    . ILE B  1 152 ? 124.776 101.221 137.540 1.00 51.36  ? 152 ILE A C    1 
ATOM   3219 O O    . ILE B  1 152 ? 125.276 100.202 138.027 1.00 53.16  ? 152 ILE A O    1 
ATOM   3220 C CB   . ILE B  1 152 ? 122.832 100.910 135.944 1.00 49.04  ? 152 ILE A CB   1 
ATOM   3221 C CG1  . ILE B  1 152 ? 123.079 99.416  135.750 1.00 49.66  ? 152 ILE A CG1  1 
ATOM   3222 C CG2  . ILE B  1 152 ? 123.581 101.697 134.892 1.00 45.98  ? 152 ILE A CG2  1 
ATOM   3223 C CD1  . ILE B  1 152 ? 122.358 98.553  136.754 1.00 52.18  ? 152 ILE A CD1  1 
ATOM   3224 N N    . ILE B  1 153 ? 125.526 102.255 137.150 1.00 55.97  ? 153 ILE A N    1 
ATOM   3225 C CA   . ILE B  1 153 ? 126.973 102.224 137.353 1.00 51.77  ? 153 ILE A CA   1 
ATOM   3226 C C    . ILE B  1 153 ? 127.297 102.145 138.838 1.00 54.22  ? 153 ILE A C    1 
ATOM   3227 O O    . ILE B  1 153 ? 128.163 101.366 139.263 1.00 57.12  ? 153 ILE A O    1 
ATOM   3228 C CB   . ILE B  1 153 ? 127.638 103.449 136.702 1.00 48.51  ? 153 ILE A CB   1 
ATOM   3229 C CG1  . ILE B  1 153 ? 127.498 103.394 135.183 1.00 51.38  ? 153 ILE A CG1  1 
ATOM   3230 C CG2  . ILE B  1 153 ? 129.098 103.526 137.093 1.00 49.64  ? 153 ILE A CG2  1 
ATOM   3231 C CD1  . ILE B  1 153 ? 128.174 104.543 134.478 1.00 52.44  ? 153 ILE A CD1  1 
ATOM   3232 N N    . ALA B  1 154 ? 126.617 102.956 139.651 1.00 62.72  ? 154 ALA A N    1 
ATOM   3233 C CA   . ALA B  1 154 ? 126.863 102.914 141.088 1.00 60.33  ? 154 ALA A CA   1 
ATOM   3234 C C    . ALA B  1 154 ? 126.541 101.539 141.656 1.00 57.79  ? 154 ALA A C    1 
ATOM   3235 O O    . ALA B  1 154 ? 127.297 101.000 142.475 1.00 62.84  ? 154 ALA A O    1 
ATOM   3236 C CB   . ALA B  1 154 ? 126.044 103.990 141.796 1.00 61.24  ? 154 ALA A CB   1 
ATOM   3237 N N    . TYR B  1 155 ? 125.422 100.954 141.228 1.00 66.93  ? 155 TYR A N    1 
ATOM   3238 C CA   . TYR B  1 155 ? 125.051 99.632  141.718 1.00 70.42  ? 155 TYR A CA   1 
ATOM   3239 C C    . TYR B  1 155 ? 126.094 98.592  141.333 1.00 70.19  ? 155 TYR A C    1 
ATOM   3240 O O    . TYR B  1 155 ? 126.457 97.735  142.148 1.00 70.19  ? 155 TYR A O    1 
ATOM   3241 C CB   . TYR B  1 155 ? 123.679 99.243  141.173 1.00 69.38  ? 155 TYR A CB   1 
ATOM   3242 C CG   . TYR B  1 155 ? 123.050 98.067  141.875 1.00 72.14  ? 155 TYR A CG   1 
ATOM   3243 C CD1  . TYR B  1 155 ? 123.402 96.766  141.543 1.00 72.17  ? 155 TYR A CD1  1 
ATOM   3244 C CD2  . TYR B  1 155 ? 122.096 98.255  142.863 1.00 73.28  ? 155 TYR A CD2  1 
ATOM   3245 C CE1  . TYR B  1 155 ? 122.826 95.686  142.182 1.00 73.65  ? 155 TYR A CE1  1 
ATOM   3246 C CE2  . TYR B  1 155 ? 121.513 97.183  143.508 1.00 75.57  ? 155 TYR A CE2  1 
ATOM   3247 C CZ   . TYR B  1 155 ? 121.881 95.901  143.163 1.00 77.13  ? 155 TYR A CZ   1 
ATOM   3248 O OH   . TYR B  1 155 ? 121.304 94.827  143.802 1.00 74.02  ? 155 TYR A OH   1 
ATOM   3249 N N    . ILE B  1 156 ? 126.587 98.650  140.095 1.00 69.39  ? 156 ILE A N    1 
ATOM   3250 C CA   . ILE B  1 156 ? 127.585 97.683  139.645 1.00 68.05  ? 156 ILE A CA   1 
ATOM   3251 C C    . ILE B  1 156 ? 128.857 97.813  140.470 1.00 68.79  ? 156 ILE A C    1 
ATOM   3252 O O    . ILE B  1 156 ? 129.443 96.814  140.900 1.00 67.63  ? 156 ILE A O    1 
ATOM   3253 C CB   . ILE B  1 156 ? 127.874 97.860  138.145 1.00 66.18  ? 156 ILE A CB   1 
ATOM   3254 C CG1  . ILE B  1 156 ? 126.639 97.515  137.315 1.00 68.03  ? 156 ILE A CG1  1 
ATOM   3255 C CG2  . ILE B  1 156 ? 129.052 97.000  137.729 1.00 65.86  ? 156 ILE A CG2  1 
ATOM   3256 C CD1  . ILE B  1 156 ? 126.864 97.635  135.827 1.00 67.14  ? 156 ILE A CD1  1 
ATOM   3257 N N    . MET B  1 157 ? 129.312 99.049  140.689 1.00 81.50  ? 157 MET A N    1 
ATOM   3258 C CA   . MET B  1 157 ? 130.527 99.244  141.475 1.00 80.43  ? 157 MET A CA   1 
ATOM   3259 C C    . MET B  1 157 ? 130.352 98.721  142.894 1.00 80.59  ? 157 MET A C    1 
ATOM   3260 O O    . MET B  1 157 ? 131.237 98.040  143.428 1.00 80.71  ? 157 MET A O    1 
ATOM   3261 C CB   . MET B  1 157 ? 130.916 100.721 141.489 1.00 77.34  ? 157 MET A CB   1 
ATOM   3262 C CG   . MET B  1 157 ? 131.505 101.216 140.183 1.00 79.89  ? 157 MET A CG   1 
ATOM   3263 S SD   . MET B  1 157 ? 131.839 102.988 140.192 1.00 91.19  ? 157 MET A SD   1 
ATOM   3264 C CE   . MET B  1 157 ? 132.905 103.129 141.621 1.00 81.97  ? 157 MET A CE   1 
ATOM   3265 N N    . LYS B  1 158 ? 129.214 99.027  143.521 1.00 86.86  ? 158 LYS A N    1 
ATOM   3266 C CA   . LYS B  1 158 ? 128.976 98.559  144.882 1.00 87.21  ? 158 LYS A CA   1 
ATOM   3267 C C    . LYS B  1 158 ? 128.960 97.037  144.939 1.00 88.04  ? 158 LYS A C    1 
ATOM   3268 O O    . LYS B  1 158 ? 129.570 96.431  145.829 1.00 89.44  ? 158 LYS A O    1 
ATOM   3269 C CB   . LYS B  1 158 ? 127.664 99.140  145.410 1.00 86.22  ? 158 LYS A CB   1 
ATOM   3270 C CG   . LYS B  1 158 ? 127.334 98.777  146.849 1.00 87.29  ? 158 LYS A CG   1 
ATOM   3271 C CD   . LYS B  1 158 ? 126.652 97.422  146.945 1.00 86.55  ? 158 LYS A CD   1 
ATOM   3272 C CE   . LYS B  1 158 ? 126.162 97.155  148.358 1.00 86.00  ? 158 LYS A CE   1 
ATOM   3273 N NZ   . LYS B  1 158 ? 125.174 98.177  148.800 1.00 86.19  ? 158 LYS A NZ   1 
ATOM   3274 N N    . SER B  1 159 ? 128.267 96.400  143.994 1.00 89.60  ? 159 SER A N    1 
ATOM   3275 C CA   . SER B  1 159 ? 128.195 94.943  143.991 1.00 90.27  ? 159 SER A CA   1 
ATOM   3276 C C    . SER B  1 159 ? 129.568 94.324  143.781 1.00 90.29  ? 159 SER A C    1 
ATOM   3277 O O    . SER B  1 159 ? 129.925 93.346  144.447 1.00 90.35  ? 159 SER A O    1 
ATOM   3278 C CB   . SER B  1 159 ? 127.223 94.466  142.913 1.00 91.60  ? 159 SER A CB   1 
ATOM   3279 O OG   . SER B  1 159 ? 127.190 93.051  142.853 1.00 91.66  ? 159 SER A OG   1 
ATOM   3280 N N    . CYS B  1 160 ? 130.352 94.875  142.851 1.00 94.91  ? 160 CYS A N    1 
ATOM   3281 C CA   . CYS B  1 160 ? 131.680 94.332  142.598 1.00 96.42  ? 160 CYS A CA   1 
ATOM   3282 C C    . CYS B  1 160 ? 132.566 94.458  143.829 1.00 95.65  ? 160 CYS A C    1 
ATOM   3283 O O    . CYS B  1 160 ? 133.267 93.508  144.199 1.00 95.53  ? 160 CYS A O    1 
ATOM   3284 C CB   . CYS B  1 160 ? 132.319 95.036  141.402 1.00 96.14  ? 160 CYS A CB   1 
ATOM   3285 S SG   . CYS B  1 160 ? 133.992 94.478  141.014 1.00 95.47  ? 160 CYS A SG   1 
ATOM   3286 N N    . HIS B  1 161 ? 132.546 95.623  144.482 1.00 101.02 ? 161 HIS A N    1 
ATOM   3287 C CA   . HIS B  1 161 ? 133.356 95.793  145.682 1.00 102.90 ? 161 HIS A CA   1 
ATOM   3288 C C    . HIS B  1 161 ? 132.920 94.835  146.781 1.00 102.74 ? 161 HIS A C    1 
ATOM   3289 O O    . HIS B  1 161 ? 133.760 94.218  147.447 1.00 101.76 ? 161 HIS A O    1 
ATOM   3290 C CB   . HIS B  1 161 ? 133.279 97.238  146.171 1.00 101.93 ? 161 HIS A CB   1 
ATOM   3291 C CG   . HIS B  1 161 ? 133.960 97.463  147.484 1.00 101.52 ? 161 HIS A CG   1 
ATOM   3292 N ND1  . HIS B  1 161 ? 133.341 97.229  148.692 1.00 101.74 ? 161 HIS A ND1  1 
ATOM   3293 C CD2  . HIS B  1 161 ? 135.208 97.898  147.779 1.00 101.26 ? 161 HIS A CD2  1 
ATOM   3294 C CE1  . HIS B  1 161 ? 134.177 97.512  149.676 1.00 102.18 ? 161 HIS A CE1  1 
ATOM   3295 N NE2  . HIS B  1 161 ? 135.317 97.920  149.148 1.00 103.48 ? 161 HIS A NE2  1 
ATOM   3296 N N    . GLN B  1 162 ? 131.609 94.690  146.983 1.00 106.02 ? 162 GLN A N    1 
ATOM   3297 C CA   . GLN B  1 162 ? 131.126 93.792  148.027 1.00 106.42 ? 162 GLN A CA   1 
ATOM   3298 C C    . GLN B  1 162 ? 131.534 92.354  147.743 1.00 106.62 ? 162 GLN A C    1 
ATOM   3299 O O    . GLN B  1 162 ? 131.973 91.635  148.648 1.00 106.01 ? 162 GLN A O    1 
ATOM   3300 C CB   . GLN B  1 162 ? 129.607 93.911  148.159 1.00 105.98 ? 162 GLN A CB   1 
ATOM   3301 C CG   . GLN B  1 162 ? 129.010 93.143  149.329 1.00 105.93 ? 162 GLN A CG   1 
ATOM   3302 C CD   . GLN B  1 162 ? 128.786 91.676  149.017 1.00 107.41 ? 162 GLN A CD   1 
ATOM   3303 O OE1  . GLN B  1 162 ? 128.831 91.262  147.860 1.00 107.75 ? 162 GLN A OE1  1 
ATOM   3304 N NE2  . GLN B  1 162 ? 128.541 90.882  150.052 1.00 106.24 ? 162 GLN A NE2  1 
ATOM   3305 N N    . ARG B  1 163 ? 131.400 91.914  146.490 1.00 109.18 ? 163 ARG A N    1 
ATOM   3306 C CA   . ARG B  1 163 ? 131.773 90.545  146.151 1.00 109.73 ? 163 ARG A CA   1 
ATOM   3307 C C    . ARG B  1 163 ? 133.270 90.325  146.324 1.00 110.73 ? 163 ARG A C    1 
ATOM   3308 O O    . ARG B  1 163 ? 133.694 89.282  146.833 1.00 110.15 ? 163 ARG A O    1 
ATOM   3309 C CB   . ARG B  1 163 ? 131.342 90.216  144.723 1.00 109.25 ? 163 ARG A CB   1 
ATOM   3310 C CG   . ARG B  1 163 ? 131.373 88.732  144.397 1.00 109.23 ? 163 ARG A CG   1 
ATOM   3311 C CD   . ARG B  1 163 ? 130.896 88.461  142.982 1.00 108.74 ? 163 ARG A CD   1 
ATOM   3312 N NE   . ARG B  1 163 ? 131.823 88.985  141.987 1.00 110.03 ? 163 ARG A NE   1 
ATOM   3313 C CZ   . ARG B  1 163 ? 132.851 88.306  141.495 1.00 110.46 ? 163 ARG A CZ   1 
ATOM   3314 N NH1  . ARG B  1 163 ? 133.113 87.070  141.885 1.00 108.95 ? 163 ARG A NH1  1 
ATOM   3315 N NH2  . ARG B  1 163 ? 133.636 88.882  140.590 1.00 110.45 ? 163 ARG A NH2  1 
ATOM   3316 N N    . GLN B  1 164 ? 134.088 91.295  145.907 1.00 115.23 ? 164 GLN A N    1 
ATOM   3317 C CA   . GLN B  1 164 ? 135.529 91.158  146.068 1.00 115.64 ? 164 GLN A CA   1 
ATOM   3318 C C    . GLN B  1 164 ? 135.954 91.207  147.528 1.00 115.63 ? 164 GLN A C    1 
ATOM   3319 O O    . GLN B  1 164 ? 137.006 90.659  147.872 1.00 114.46 ? 164 GLN A O    1 
ATOM   3320 C CB   . GLN B  1 164 ? 136.254 92.247  145.277 1.00 114.64 ? 164 GLN A CB   1 
ATOM   3321 C CG   . GLN B  1 164 ? 137.767 92.175  145.377 1.00 114.44 ? 164 GLN A CG   1 
ATOM   3322 C CD   . GLN B  1 164 ? 138.456 93.209  144.512 1.00 115.66 ? 164 GLN A CD   1 
ATOM   3323 O OE1  . GLN B  1 164 ? 137.809 93.927  143.749 1.00 116.07 ? 164 GLN A OE1  1 
ATOM   3324 N NE2  . GLN B  1 164 ? 139.776 93.294  144.626 1.00 114.77 ? 164 GLN A NE2  1 
ATOM   3325 N N    . LEU B  1 165 ? 135.163 91.850  148.392 1.00 116.63 ? 165 LEU A N    1 
ATOM   3326 C CA   . LEU B  1 165 ? 135.497 91.868  149.812 1.00 116.87 ? 165 LEU A CA   1 
ATOM   3327 C C    . LEU B  1 165 ? 135.572 90.459  150.382 1.00 117.29 ? 165 LEU A C    1 
ATOM   3328 O O    . LEU B  1 165 ? 136.371 90.197  151.289 1.00 116.49 ? 165 LEU A O    1 
ATOM   3329 C CB   . LEU B  1 165 ? 134.472 92.706  150.580 1.00 117.06 ? 165 LEU A CB   1 
ATOM   3330 C CG   . LEU B  1 165 ? 134.726 92.979  152.066 1.00 116.71 ? 165 LEU A CG   1 
ATOM   3331 C CD1  . LEU B  1 165 ? 133.888 94.158  152.532 1.00 115.86 ? 165 LEU A CD1  1 
ATOM   3332 C CD2  . LEU B  1 165 ? 134.426 91.754  152.917 1.00 115.52 ? 165 LEU A CD2  1 
ATOM   3333 N N    . ARG B  1 166 ? 134.755 89.540  149.865 1.00 119.07 ? 166 ARG A N    1 
ATOM   3334 C CA   . ARG B  1 166 ? 134.759 88.150  150.319 1.00 118.95 ? 166 ARG A CA   1 
ATOM   3335 C C    . ARG B  1 166 ? 135.982 87.455  149.728 1.00 119.91 ? 166 ARG A C    1 
ATOM   3336 O O    . ARG B  1 166 ? 135.910 86.707  148.750 1.00 118.32 ? 166 ARG A O    1 
ATOM   3337 C CB   . ARG B  1 166 ? 133.466 87.450  149.921 1.00 117.49 ? 166 ARG A CB   1 
ATOM   3338 C CG   . ARG B  1 166 ? 133.386 86.000  150.363 1.00 116.48 ? 166 ARG A CG   1 
ATOM   3339 C CD   . ARG B  1 166 ? 132.129 85.331  149.835 1.00 116.98 ? 166 ARG A CD   1 
ATOM   3340 N NE   . ARG B  1 166 ? 132.101 85.297  148.377 1.00 119.28 ? 166 ARG A NE   1 
ATOM   3341 C CZ   . ARG B  1 166 ? 132.618 84.322  147.642 1.00 118.80 ? 166 ARG A CZ   1 
ATOM   3342 N NH1  . ARG B  1 166 ? 133.214 83.279  148.195 1.00 118.29 ? 166 ARG A NH1  1 
ATOM   3343 N NH2  . ARG B  1 166 ? 132.533 84.396  146.317 1.00 116.78 ? 166 ARG A NH2  1 
ATOM   3344 N N    . ARG B  1 167 ? 137.131 87.715  150.344 1.00 121.44 ? 167 ARG A N    1 
ATOM   3345 C CA   . ARG B  1 167 ? 138.390 87.137  149.891 1.00 120.17 ? 167 ARG A CA   1 
ATOM   3346 C C    . ARG B  1 167 ? 139.356 86.955  151.056 1.00 118.50 ? 167 ARG A C    1 
ATOM   3347 O O    . ARG B  1 167 ? 139.193 87.569  152.111 1.00 118.24 ? 167 ARG A O    1 
ATOM   3348 C CB   . ARG B  1 167 ? 139.024 88.015  148.812 1.00 119.63 ? 167 ARG A CB   1 
ATOM   3349 C CG   . ARG B  1 167 ? 140.280 87.426  148.194 1.00 118.98 ? 167 ARG A CG   1 
ATOM   3350 C CD   . ARG B  1 167 ? 139.983 86.104  147.507 1.00 118.82 ? 167 ARG A CD   1 
ATOM   3351 N NE   . ARG B  1 167 ? 138.985 86.252  146.455 1.00 119.43 ? 167 ARG A NE   1 
ATOM   3352 C CZ   . ARG B  1 167 ? 138.532 85.255  145.707 1.00 119.46 ? 167 ARG A CZ   1 
ATOM   3353 N NH1  . ARG B  1 167 ? 138.967 84.015  145.870 1.00 119.94 ? 167 ARG A NH1  1 
ATOM   3354 N NH2  . ARG B  1 167 ? 137.620 85.507  144.772 1.00 118.38 ? 167 ARG A NH2  1 
ATOM   3355 N N    . ALA B  1 188 ? 123.710 103.951 146.682 1.00 87.98  ? 188 ALA A N    1 
ATOM   3356 C CA   . ALA B  1 188 ? 123.636 104.799 147.866 1.00 91.47  ? 188 ALA A CA   1 
ATOM   3357 C C    . ALA B  1 188 ? 124.759 105.831 147.876 1.00 92.85  ? 188 ALA A C    1 
ATOM   3358 O O    . ALA B  1 188 ? 124.649 106.890 147.259 1.00 90.41  ? 188 ALA A O    1 
ATOM   3359 C CB   . ALA B  1 188 ? 123.681 103.951 149.127 1.00 88.08  ? 188 ALA A CB   1 
ATOM   3360 N N    . GLY B  1 189 ? 125.842 105.514 148.582 1.00 90.77  ? 189 GLY A N    1 
ATOM   3361 C CA   . GLY B  1 189 ? 126.981 106.406 148.667 1.00 88.41  ? 189 GLY A CA   1 
ATOM   3362 C C    . GLY B  1 189 ? 128.104 106.040 147.719 1.00 88.25  ? 189 GLY A C    1 
ATOM   3363 O O    . GLY B  1 189 ? 129.248 106.464 147.905 1.00 86.03  ? 189 GLY A O    1 
ATOM   3364 N N    . TRP B  1 190 ? 127.788 105.247 146.693 1.00 86.54  ? 190 TRP A N    1 
ATOM   3365 C CA   . TRP B  1 190 ? 128.773 104.779 145.727 1.00 83.35  ? 190 TRP A CA   1 
ATOM   3366 C C    . TRP B  1 190 ? 128.670 105.508 144.393 1.00 82.45  ? 190 TRP A C    1 
ATOM   3367 O O    . TRP B  1 190 ? 129.104 104.978 143.367 1.00 85.62  ? 190 TRP A O    1 
ATOM   3368 C CB   . TRP B  1 190 ? 128.628 103.273 145.516 1.00 83.53  ? 190 TRP A CB   1 
ATOM   3369 C CG   . TRP B  1 190 ? 128.739 102.474 146.773 1.00 87.07  ? 190 TRP A CG   1 
ATOM   3370 C CD1  . TRP B  1 190 ? 127.765 102.276 147.706 1.00 86.41  ? 190 TRP A CD1  1 
ATOM   3371 C CD2  . TRP B  1 190 ? 129.887 101.754 147.233 1.00 88.28  ? 190 TRP A CD2  1 
ATOM   3372 N NE1  . TRP B  1 190 ? 128.237 101.483 148.722 1.00 85.42  ? 190 TRP A NE1  1 
ATOM   3373 C CE2  . TRP B  1 190 ? 129.538 101.148 148.455 1.00 87.75  ? 190 TRP A CE2  1 
ATOM   3374 C CE3  . TRP B  1 190 ? 131.179 101.566 146.733 1.00 87.15  ? 190 TRP A CE3  1 
ATOM   3375 C CZ2  . TRP B  1 190 ? 130.432 100.368 149.183 1.00 87.21  ? 190 TRP A CZ2  1 
ATOM   3376 C CZ3  . TRP B  1 190 ? 132.064 100.791 147.457 1.00 86.59  ? 190 TRP A CZ3  1 
ATOM   3377 C CH2  . TRP B  1 190 ? 131.687 100.201 148.669 1.00 87.27  ? 190 TRP A CH2  1 
ATOM   3378 N N    . LYS B  1 191 ? 128.108 106.710 144.384 1.00 71.66  ? 191 LYS A N    1 
ATOM   3379 C CA   . LYS B  1 191 ? 127.950 107.443 143.138 1.00 72.55  ? 191 LYS A CA   1 
ATOM   3380 C C    . LYS B  1 191 ? 129.316 107.700 142.509 1.00 72.11  ? 191 LYS A C    1 
ATOM   3381 O O    . LYS B  1 191 ? 130.218 108.213 143.185 1.00 74.33  ? 191 LYS A O    1 
ATOM   3382 C CB   . LYS B  1 191 ? 127.228 108.766 143.382 1.00 73.44  ? 191 LYS A CB   1 
ATOM   3383 C CG   . LYS B  1 191 ? 125.811 108.616 143.907 1.00 76.81  ? 191 LYS A CG   1 
ATOM   3384 C CD   . LYS B  1 191 ? 124.906 107.954 142.883 1.00 74.58  ? 191 LYS A CD   1 
ATOM   3385 C CE   . LYS B  1 191 ? 123.477 107.868 143.392 1.00 73.14  ? 191 LYS A CE   1 
ATOM   3386 N NZ   . LYS B  1 191 ? 122.565 107.242 142.397 1.00 71.37  ? 191 LYS A NZ   1 
ATOM   3387 N N    . PRO B  1 192 ? 129.511 107.365 141.238 1.00 65.92  ? 192 PRO A N    1 
ATOM   3388 C CA   . PRO B  1 192 ? 130.805 107.611 140.600 1.00 66.91  ? 192 PRO A CA   1 
ATOM   3389 C C    . PRO B  1 192 ? 131.051 109.097 140.388 1.00 65.87  ? 192 PRO A C    1 
ATOM   3390 O O    . PRO B  1 192 ? 130.126 109.906 140.299 1.00 66.80  ? 192 PRO A O    1 
ATOM   3391 C CB   . PRO B  1 192 ? 130.685 106.874 139.265 1.00 64.17  ? 192 PRO A CB   1 
ATOM   3392 C CG   . PRO B  1 192 ? 129.229 106.894 138.973 1.00 62.31  ? 192 PRO A CG   1 
ATOM   3393 C CD   . PRO B  1 192 ? 128.540 106.771 140.304 1.00 63.37  ? 192 PRO A CD   1 
ATOM   3394 N N    . SER B  1 193 ? 132.331 109.448 140.309 1.00 57.63  ? 193 SER A N    1 
ATOM   3395 C CA   . SER B  1 193 ? 132.710 110.824 140.042 1.00 54.48  ? 193 SER A CA   1 
ATOM   3396 C C    . SER B  1 193 ? 132.414 111.180 138.586 1.00 56.37  ? 193 SER A C    1 
ATOM   3397 O O    . SER B  1 193 ? 132.145 110.319 137.746 1.00 61.26  ? 193 SER A O    1 
ATOM   3398 C CB   . SER B  1 193 ? 134.188 111.043 140.355 1.00 56.05  ? 193 SER A CB   1 
ATOM   3399 O OG   . SER B  1 193 ? 135.003 110.182 139.581 1.00 58.18  ? 193 SER A OG   1 
ATOM   3400 N N    . VAL B  1 194 ? 132.466 112.479 138.291 1.00 45.07  ? 194 VAL A N    1 
ATOM   3401 C CA   . VAL B  1 194 ? 132.160 112.943 136.942 1.00 47.15  ? 194 VAL A CA   1 
ATOM   3402 C C    . VAL B  1 194 ? 133.192 112.424 135.949 1.00 50.52  ? 194 VAL A C    1 
ATOM   3403 O O    . VAL B  1 194 ? 132.867 112.115 134.797 1.00 54.75  ? 194 VAL A O    1 
ATOM   3404 C CB   . VAL B  1 194 ? 132.071 114.479 136.912 1.00 47.87  ? 194 VAL A CB   1 
ATOM   3405 C CG1  . VAL B  1 194 ? 131.742 114.959 135.514 1.00 46.57  ? 194 VAL A CG1  1 
ATOM   3406 C CG2  . VAL B  1 194 ? 131.029 114.962 137.902 1.00 48.64  ? 194 VAL A CG2  1 
ATOM   3407 N N    . TYR B  1 195 ? 134.450 112.327 136.376 1.00 49.99  ? 195 TYR A N    1 
ATOM   3408 C CA   . TYR B  1 195 ? 135.512 111.887 135.478 1.00 49.97  ? 195 TYR A CA   1 
ATOM   3409 C C    . TYR B  1 195 ? 135.257 110.473 134.967 1.00 57.01  ? 195 TYR A C    1 
ATOM   3410 O O    . TYR B  1 195 ? 135.371 110.198 133.764 1.00 59.36  ? 195 TYR A O    1 
ATOM   3411 C CB   . TYR B  1 195 ? 136.852 111.980 136.207 1.00 50.71  ? 195 TYR A CB   1 
ATOM   3412 C CG   . TYR B  1 195 ? 138.057 111.626 135.375 1.00 57.20  ? 195 TYR A CG   1 
ATOM   3413 C CD1  . TYR B  1 195 ? 138.562 112.514 134.440 1.00 57.68  ? 195 TYR A CD1  1 
ATOM   3414 C CD2  . TYR B  1 195 ? 138.704 110.410 135.541 1.00 54.34  ? 195 TYR A CD2  1 
ATOM   3415 C CE1  . TYR B  1 195 ? 139.669 112.195 133.682 1.00 59.43  ? 195 TYR A CE1  1 
ATOM   3416 C CE2  . TYR B  1 195 ? 139.809 110.083 134.789 1.00 52.11  ? 195 TYR A CE2  1 
ATOM   3417 C CZ   . TYR B  1 195 ? 140.288 110.979 133.861 1.00 58.69  ? 195 TYR A CZ   1 
ATOM   3418 O OH   . TYR B  1 195 ? 141.392 110.655 133.109 1.00 61.04  ? 195 TYR A OH   1 
ATOM   3419 N N    . TYR B  1 196 ? 134.899 109.556 135.869 1.00 52.91  ? 196 TYR A N    1 
ATOM   3420 C CA   . TYR B  1 196 ? 134.652 108.179 135.456 1.00 51.44  ? 196 TYR A CA   1 
ATOM   3421 C C    . TYR B  1 196 ? 133.435 108.084 134.546 1.00 51.51  ? 196 TYR A C    1 
ATOM   3422 O O    . TYR B  1 196 ? 133.434 107.311 133.580 1.00 58.64  ? 196 TYR A O    1 
ATOM   3423 C CB   . TYR B  1 196 ? 134.482 107.286 136.682 1.00 51.18  ? 196 TYR A CB   1 
ATOM   3424 C CG   . TYR B  1 196 ? 135.737 107.164 137.511 1.00 59.22  ? 196 TYR A CG   1 
ATOM   3425 C CD1  . TYR B  1 196 ? 136.969 107.539 136.995 1.00 58.32  ? 196 TYR A CD1  1 
ATOM   3426 C CD2  . TYR B  1 196 ? 135.692 106.674 138.807 1.00 60.59  ? 196 TYR A CD2  1 
ATOM   3427 C CE1  . TYR B  1 196 ? 138.121 107.431 137.747 1.00 56.11  ? 196 TYR A CE1  1 
ATOM   3428 C CE2  . TYR B  1 196 ? 136.840 106.562 139.568 1.00 59.78  ? 196 TYR A CE2  1 
ATOM   3429 C CZ   . TYR B  1 196 ? 138.051 106.943 139.032 1.00 60.18  ? 196 TYR A CZ   1 
ATOM   3430 O OH   . TYR B  1 196 ? 139.198 106.833 139.786 1.00 60.10  ? 196 TYR A OH   1 
ATOM   3431 N N    . VAL B  1 197 ? 132.387 108.854 134.840 1.00 40.17  ? 197 VAL A N    1 
ATOM   3432 C CA   . VAL B  1 197 ? 131.211 108.849 133.976 1.00 40.33  ? 197 VAL A CA   1 
ATOM   3433 C C    . VAL B  1 197 ? 131.578 109.344 132.584 1.00 42.69  ? 197 VAL A C    1 
ATOM   3434 O O    . VAL B  1 197 ? 131.116 108.798 131.575 1.00 47.40  ? 197 VAL A O    1 
ATOM   3435 C CB   . VAL B  1 197 ? 130.084 109.691 134.597 1.00 42.74  ? 197 VAL A CB   1 
ATOM   3436 C CG1  . VAL B  1 197 ? 128.907 109.772 133.646 1.00 40.58  ? 197 VAL A CG1  1 
ATOM   3437 C CG2  . VAL B  1 197 ? 129.656 109.098 135.923 1.00 45.20  ? 197 VAL A CG2  1 
ATOM   3438 N N    . MET B  1 198 ? 132.407 110.386 132.504 1.00 46.64  ? 198 MET A N    1 
ATOM   3439 C CA   . MET B  1 198 ? 132.833 110.878 131.200 1.00 42.82  ? 198 MET A CA   1 
ATOM   3440 C C    . MET B  1 198 ? 133.622 109.819 130.445 1.00 46.07  ? 198 MET A C    1 
ATOM   3441 O O    . MET B  1 198 ? 133.423 109.629 129.240 1.00 55.52  ? 198 MET A O    1 
ATOM   3442 C CB   . MET B  1 198 ? 133.668 112.147 131.356 1.00 45.76  ? 198 MET A CB   1 
ATOM   3443 C CG   . MET B  1 198 ? 134.115 112.738 130.034 1.00 52.50  ? 198 MET A CG   1 
ATOM   3444 S SD   . MET B  1 198 ? 135.345 114.038 130.211 1.00 67.48  ? 198 MET A SD   1 
ATOM   3445 C CE   . MET B  1 198 ? 136.712 113.112 130.897 1.00 51.57  ? 198 MET A CE   1 
ATOM   3446 N N    . LEU B  1 199 ? 134.529 109.123 131.133 1.00 42.40  ? 199 LEU A N    1 
ATOM   3447 C CA   . LEU B  1 199 ? 135.296 108.074 130.464 1.00 42.85  ? 199 LEU A CA   1 
ATOM   3448 C C    . LEU B  1 199 ? 134.382 106.970 129.944 1.00 45.54  ? 199 LEU A C    1 
ATOM   3449 O O    . LEU B  1 199 ? 134.545 106.493 128.812 1.00 49.46  ? 199 LEU A O    1 
ATOM   3450 C CB   . LEU B  1 199 ? 136.344 107.501 131.415 1.00 39.34  ? 199 LEU A CB   1 
ATOM   3451 C CG   . LEU B  1 199 ? 137.411 108.473 131.912 1.00 44.89  ? 199 LEU A CG   1 
ATOM   3452 C CD1  . LEU B  1 199 ? 138.459 107.740 132.729 1.00 47.01  ? 199 LEU A CD1  1 
ATOM   3453 C CD2  . LEU B  1 199 ? 138.052 109.206 130.748 1.00 44.24  ? 199 LEU A CD2  1 
ATOM   3454 N N    . ILE B  1 200 ? 133.411 106.554 130.758 1.00 41.08  ? 200 ILE A N    1 
ATOM   3455 C CA   . ILE B  1 200 ? 132.493 105.496 130.343 1.00 36.62  ? 200 ILE A CA   1 
ATOM   3456 C C    . ILE B  1 200 ? 131.678 105.939 129.137 1.00 38.37  ? 200 ILE A C    1 
ATOM   3457 O O    . ILE B  1 200 ? 131.477 105.171 128.187 1.00 41.13  ? 200 ILE A O    1 
ATOM   3458 C CB   . ILE B  1 200 ? 131.589 105.083 131.516 1.00 35.94  ? 200 ILE A CB   1 
ATOM   3459 C CG1  . ILE B  1 200 ? 132.409 104.375 132.592 1.00 39.54  ? 200 ILE A CG1  1 
ATOM   3460 C CG2  . ILE B  1 200 ? 130.458 104.202 131.026 1.00 34.88  ? 200 ILE A CG2  1 
ATOM   3461 C CD1  . ILE B  1 200 ? 131.602 103.960 133.794 1.00 36.62  ? 200 ILE A CD1  1 
ATOM   3462 N N    . LEU B  1 201 ? 131.184 107.177 129.157 1.00 35.03  ? 201 LEU A N    1 
ATOM   3463 C CA   . LEU B  1 201 ? 130.408 107.673 128.026 1.00 32.38  ? 201 LEU A CA   1 
ATOM   3464 C C    . LEU B  1 201 ? 131.255 107.742 126.763 1.00 39.01  ? 201 LEU A C    1 
ATOM   3465 O O    . LEU B  1 201 ? 130.777 107.421 125.671 1.00 44.84  ? 201 LEU A O    1 
ATOM   3466 C CB   . LEU B  1 201 ? 129.812 109.039 128.354 1.00 33.01  ? 201 LEU A CB   1 
ATOM   3467 C CG   . LEU B  1 201 ? 128.643 109.016 129.337 1.00 34.11  ? 201 LEU A CG   1 
ATOM   3468 C CD1  . LEU B  1 201 ? 128.104 110.414 129.555 1.00 36.56  ? 201 LEU A CD1  1 
ATOM   3469 C CD2  . LEU B  1 201 ? 127.551 108.096 128.831 1.00 35.49  ? 201 LEU A CD2  1 
ATOM   3470 N N    . CYS B  1 202 ? 132.514 108.168 126.887 1.00 42.66  ? 202 CYS A N    1 
ATOM   3471 C CA   . CYS B  1 202 ? 133.389 108.213 125.720 1.00 37.35  ? 202 CYS A CA   1 
ATOM   3472 C C    . CYS B  1 202 ? 133.597 106.820 125.138 1.00 41.53  ? 202 CYS A C    1 
ATOM   3473 O O    . CYS B  1 202 ? 133.523 106.623 123.917 1.00 44.38  ? 202 CYS A O    1 
ATOM   3474 C CB   . CYS B  1 202 ? 134.731 108.844 126.090 1.00 35.77  ? 202 CYS A CB   1 
ATOM   3475 S SG   . CYS B  1 202 ? 134.652 110.606 126.460 1.00 58.46  ? 202 CYS A SG   1 
ATOM   3476 N N    . THR B  1 203 ? 133.858 105.835 126.001 1.00 39.67  ? 203 THR A N    1 
ATOM   3477 C CA   . THR B  1 203 ? 134.048 104.475 125.510 1.00 34.70  ? 203 THR A CA   1 
ATOM   3478 C C    . THR B  1 203 ? 132.790 103.957 124.825 1.00 41.71  ? 203 THR A C    1 
ATOM   3479 O O    . THR B  1 203 ? 132.863 103.342 123.753 1.00 43.11  ? 203 THR A O    1 
ATOM   3480 C CB   . THR B  1 203 ? 134.449 103.551 126.657 1.00 34.23  ? 203 THR A CB   1 
ATOM   3481 O OG1  . THR B  1 203 ? 135.685 104.001 127.222 1.00 47.44  ? 203 THR A OG1  1 
ATOM   3482 C CG2  . THR B  1 203 ? 134.620 102.133 126.154 1.00 36.62  ? 203 THR A CG2  1 
ATOM   3483 N N    . ALA B  1 204 ? 131.625 104.200 125.428 1.00 43.04  ? 204 ALA A N    1 
ATOM   3484 C CA   . ALA B  1 204 ? 130.379 103.740 124.827 1.00 34.82  ? 204 ALA A CA   1 
ATOM   3485 C C    . ALA B  1 204 ? 130.148 104.395 123.474 1.00 40.62  ? 204 ALA A C    1 
ATOM   3486 O O    . ALA B  1 204 ? 129.725 103.733 122.520 1.00 48.58  ? 204 ALA A O    1 
ATOM   3487 C CB   . ALA B  1 204 ? 129.208 104.020 125.766 1.00 35.87  ? 204 ALA A CB   1 
ATOM   3488 N N    . SER B  1 205 ? 130.413 105.699 123.372 1.00 41.16  ? 205 SER A N    1 
ATOM   3489 C CA   . SER B  1 205 ? 130.228 106.390 122.101 1.00 39.14  ? 205 SER A CA   1 
ATOM   3490 C C    . SER B  1 205 ? 131.151 105.829 121.031 1.00 39.06  ? 205 SER A C    1 
ATOM   3491 O O    . SER B  1 205 ? 130.731 105.616 119.888 1.00 40.59  ? 205 SER A O    1 
ATOM   3492 C CB   . SER B  1 205 ? 130.463 107.888 122.278 1.00 34.83  ? 205 SER A CB   1 
ATOM   3493 O OG   . SER B  1 205 ? 129.591 108.425 123.254 1.00 41.27  ? 205 SER A OG   1 
ATOM   3494 N N    . ILE B  1 206 ? 132.414 105.580 121.381 1.00 39.55  ? 206 ILE A N    1 
ATOM   3495 C CA   . ILE B  1 206 ? 133.347 105.027 120.404 1.00 36.43  ? 206 ILE A CA   1 
ATOM   3496 C C    . ILE B  1 206 ? 132.868 103.662 119.928 1.00 39.28  ? 206 ILE A C    1 
ATOM   3497 O O    . ILE B  1 206 ? 132.865 103.367 118.726 1.00 46.29  ? 206 ILE A O    1 
ATOM   3498 C CB   . ILE B  1 206 ? 134.765 104.951 120.994 1.00 40.56  ? 206 ILE A CB   1 
ATOM   3499 C CG1  . ILE B  1 206 ? 135.341 106.354 121.174 1.00 41.82  ? 206 ILE A CG1  1 
ATOM   3500 C CG2  . ILE B  1 206 ? 135.664 104.118 120.106 1.00 38.05  ? 206 ILE A CG2  1 
ATOM   3501 C CD1  . ILE B  1 206 ? 136.755 106.362 121.696 1.00 42.73  ? 206 ILE A CD1  1 
ATOM   3502 N N    . LEU B  1 207 ? 132.455 102.805 120.866 1.00 37.88  ? 207 LEU A N    1 
ATOM   3503 C CA   . LEU B  1 207 ? 132.007 101.471 120.482 1.00 36.26  ? 207 LEU A CA   1 
ATOM   3504 C C    . LEU B  1 207 ? 130.774 101.535 119.590 1.00 40.89  ? 207 LEU A C    1 
ATOM   3505 O O    . LEU B  1 207 ? 130.687 100.819 118.584 1.00 42.15  ? 207 LEU A O    1 
ATOM   3506 C CB   . LEU B  1 207 ? 131.723 100.629 121.724 1.00 41.20  ? 207 LEU A CB   1 
ATOM   3507 C CG   . LEU B  1 207 ? 132.941 100.261 122.568 1.00 47.55  ? 207 LEU A CG   1 
ATOM   3508 C CD1  . LEU B  1 207 ? 132.539 99.340  123.704 1.00 41.22  ? 207 LEU A CD1  1 
ATOM   3509 C CD2  . LEU B  1 207 ? 134.012 99.620  121.704 1.00 41.67  ? 207 LEU A CD2  1 
ATOM   3510 N N    . ILE B  1 208 ? 129.812 102.390 119.938 1.00 37.63  ? 208 ILE A N    1 
ATOM   3511 C CA   . ILE B  1 208 ? 128.596 102.492 119.139 1.00 36.81  ? 208 ILE A CA   1 
ATOM   3512 C C    . ILE B  1 208 ? 128.915 103.004 117.743 1.00 39.22  ? 208 ILE A C    1 
ATOM   3513 O O    . ILE B  1 208 ? 128.380 102.506 116.747 1.00 43.86  ? 208 ILE A O    1 
ATOM   3514 C CB   . ILE B  1 208 ? 127.560 103.384 119.844 1.00 36.10  ? 208 ILE A CB   1 
ATOM   3515 C CG1  . ILE B  1 208 ? 127.134 102.758 121.169 1.00 37.91  ? 208 ILE A CG1  1 
ATOM   3516 C CG2  . ILE B  1 208 ? 126.353 103.594 118.953 1.00 36.65  ? 208 ILE A CG2  1 
ATOM   3517 C CD1  . ILE B  1 208 ? 126.093 103.557 121.906 1.00 35.57  ? 208 ILE A CD1  1 
ATOM   3518 N N    . SER B  1 209 ? 129.784 104.013 117.645 1.00 42.10  ? 209 SER A N    1 
ATOM   3519 C CA   . SER B  1 209 ? 130.136 104.550 116.336 1.00 35.54  ? 209 SER A CA   1 
ATOM   3520 C C    . SER B  1 209 ? 130.809 103.491 115.475 1.00 34.74  ? 209 SER A C    1 
ATOM   3521 O O    . SER B  1 209 ? 130.482 103.336 114.292 1.00 43.22  ? 209 SER A O    1 
ATOM   3522 C CB   . SER B  1 209 ? 131.039 105.771 116.494 1.00 34.16  ? 209 SER A CB   1 
ATOM   3523 O OG   . SER B  1 209 ? 130.370 106.807 117.188 1.00 45.33  ? 209 SER A OG   1 
ATOM   3524 N N    . CYS B  1 210 ? 131.754 102.745 116.052 1.00 36.36  ? 210 CYS A N    1 
ATOM   3525 C CA   . CYS B  1 210 ? 132.431 101.713 115.273 1.00 35.95  ? 210 CYS A CA   1 
ATOM   3526 C C    . CYS B  1 210 ? 131.455 100.633 114.821 1.00 38.68  ? 210 CYS A C    1 
ATOM   3527 O O    . CYS B  1 210 ? 131.491 100.199 113.662 1.00 38.99  ? 210 CYS A O    1 
ATOM   3528 C CB   . CYS B  1 210 ? 133.573 101.107 116.085 1.00 35.13  ? 210 CYS A CB   1 
ATOM   3529 S SG   . CYS B  1 210 ? 134.953 102.237 116.362 1.00 50.02  ? 210 CYS A SG   1 
ATOM   3530 N N    . CYS B  1 211 ? 130.569 100.190 115.715 1.00 40.92  ? 211 CYS A N    1 
ATOM   3531 C CA   . CYS B  1 211 ? 129.613 99.154  115.340 1.00 40.58  ? 211 CYS A CA   1 
ATOM   3532 C C    . CYS B  1 211 ? 128.671 99.636  114.246 1.00 42.51  ? 211 CYS A C    1 
ATOM   3533 O O    . CYS B  1 211 ? 128.385 98.899  113.295 1.00 47.05  ? 211 CYS A O    1 
ATOM   3534 C CB   . CYS B  1 211 ? 128.824 98.696  116.566 1.00 44.46  ? 211 CYS A CB   1 
ATOM   3535 S SG   . CYS B  1 211 ? 129.820 97.833  117.799 1.00 58.51  ? 211 CYS A SG   1 
ATOM   3536 N N    . ALA B  1 212 ? 128.177 100.871 114.356 1.00 36.19  ? 212 ALA A N    1 
ATOM   3537 C CA   . ALA B  1 212 ? 127.281 101.396 113.332 1.00 32.31  ? 212 ALA A CA   1 
ATOM   3538 C C    . ALA B  1 212 ? 127.992 101.533 111.993 1.00 36.19  ? 212 ALA A C    1 
ATOM   3539 O O    . ALA B  1 212 ? 127.417 101.228 110.942 1.00 32.49  ? 212 ALA A O    1 
ATOM   3540 C CB   . ALA B  1 212 ? 126.707 102.741 113.775 1.00 25.89  ? 212 ALA A CB   1 
ATOM   3541 N N    . SER B  1 213 ? 129.242 102.001 112.008 1.00 32.63  ? 213 SER A N    1 
ATOM   3542 C CA   . SER B  1 213 ? 129.988 102.146 110.765 1.00 24.26  ? 213 SER A CA   1 
ATOM   3543 C C    . SER B  1 213 ? 130.233 100.794 110.113 1.00 32.18  ? 213 SER A C    1 
ATOM   3544 O O    . SER B  1 213 ? 130.195 100.673 108.882 1.00 38.03  ? 213 SER A O    1 
ATOM   3545 C CB   . SER B  1 213 ? 131.308 102.861 111.031 1.00 30.81  ? 213 SER A CB   1 
ATOM   3546 O OG   . SER B  1 213 ? 131.088 104.080 111.714 1.00 36.75  ? 213 SER A OG   1 
ATOM   3547 N N    . ALA B  1 214 ? 130.487 99.762  110.921 1.00 35.01  ? 214 ALA A N    1 
ATOM   3548 C CA   . ALA B  1 214 ? 130.719 98.437  110.361 1.00 31.41  ? 214 ALA A CA   1 
ATOM   3549 C C    . ALA B  1 214 ? 129.542 97.974  109.513 1.00 34.74  ? 214 ALA A C    1 
ATOM   3550 O O    . ALA B  1 214 ? 129.722 97.170  108.592 1.00 39.24  ? 214 ALA A O    1 
ATOM   3551 C CB   . ALA B  1 214 ? 130.995 97.433  111.477 1.00 27.37  ? 214 ALA A CB   1 
ATOM   3552 N N    . MET B  1 215 ? 128.338 98.464  109.804 1.00 34.38  ? 215 MET A N    1 
ATOM   3553 C CA   . MET B  1 215 ? 127.161 98.115  109.020 1.00 34.97  ? 215 MET A CA   1 
ATOM   3554 C C    . MET B  1 215 ? 126.901 99.108  107.897 1.00 36.87  ? 215 MET A C    1 
ATOM   3555 O O    . MET B  1 215 ? 126.513 98.707  106.795 1.00 37.00  ? 215 MET A O    1 
ATOM   3556 C CB   . MET B  1 215 ? 125.928 98.034  109.921 1.00 33.58  ? 215 MET A CB   1 
ATOM   3557 C CG   . MET B  1 215 ? 124.649 97.706  109.176 1.00 34.46  ? 215 MET A CG   1 
ATOM   3558 S SD   . MET B  1 215 ? 123.174 97.936  110.180 1.00 54.62  ? 215 MET A SD   1 
ATOM   3559 C CE   . MET B  1 215 ? 123.232 99.701  110.457 1.00 37.41  ? 215 MET A CE   1 
ATOM   3560 N N    . TYR B  1 216 ? 127.100 100.400 108.156 1.00 37.84  ? 216 TYR A N    1 
ATOM   3561 C CA   . TYR B  1 216 ? 126.851 101.402 107.125 1.00 26.58  ? 216 TYR A CA   1 
ATOM   3562 C C    . TYR B  1 216 ? 127.777 101.213 105.932 1.00 33.18  ? 216 TYR A C    1 
ATOM   3563 O O    . TYR B  1 216 ? 127.351 101.350 104.781 1.00 35.59  ? 216 TYR A O    1 
ATOM   3564 C CB   . TYR B  1 216 ? 127.006 102.808 107.701 1.00 24.63  ? 216 TYR A CB   1 
ATOM   3565 C CG   . TYR B  1 216 ? 125.869 103.232 108.593 1.00 27.89  ? 216 TYR A CG   1 
ATOM   3566 C CD1  . TYR B  1 216 ? 124.596 102.719 108.415 1.00 29.97  ? 216 TYR A CD1  1 
ATOM   3567 C CD2  . TYR B  1 216 ? 126.068 104.143 109.616 1.00 31.09  ? 216 TYR A CD2  1 
ATOM   3568 C CE1  . TYR B  1 216 ? 123.554 103.103 109.228 1.00 28.47  ? 216 TYR A CE1  1 
ATOM   3569 C CE2  . TYR B  1 216 ? 125.033 104.532 110.434 1.00 32.88  ? 216 TYR A CE2  1 
ATOM   3570 C CZ   . TYR B  1 216 ? 123.779 104.009 110.236 1.00 33.63  ? 216 TYR A CZ   1 
ATOM   3571 O OH   . TYR B  1 216 ? 122.744 104.396 111.052 1.00 37.45  ? 216 TYR A OH   1 
ATOM   3572 N N    . THR B  1 217 ? 129.047 100.900 106.183 1.00 34.79  ? 217 THR A N    1 
ATOM   3573 C CA   . THR B  1 217 ? 130.008 100.811 105.086 1.00 29.17  ? 217 THR A CA   1 
ATOM   3574 C C    . THR B  1 217 ? 129.616 99.785  104.033 1.00 30.65  ? 217 THR A C    1 
ATOM   3575 O O    . THR B  1 217 ? 129.623 100.126 102.839 1.00 35.48  ? 217 THR A O    1 
ATOM   3576 C CB   . THR B  1 217 ? 131.400 100.511 105.646 1.00 30.34  ? 217 THR A CB   1 
ATOM   3577 O OG1  . THR B  1 217 ? 131.841 101.615 106.442 1.00 37.14  ? 217 THR A OG1  1 
ATOM   3578 C CG2  . THR B  1 217 ? 132.382 100.284 104.516 1.00 31.26  ? 217 THR A CG2  1 
ATOM   3579 N N    . PRO B  1 218 ? 129.281 98.546  104.377 1.00 33.23  ? 218 PRO A N    1 
ATOM   3580 C CA   . PRO B  1 218 ? 128.938 97.567  103.338 1.00 27.36  ? 218 PRO A CA   1 
ATOM   3581 C C    . PRO B  1 218 ? 127.616 97.864  102.647 1.00 32.65  ? 218 PRO A C    1 
ATOM   3582 O O    . PRO B  1 218 ? 127.538 97.839  101.416 1.00 34.69  ? 218 PRO A O    1 
ATOM   3583 C CB   . PRO B  1 218 ? 128.872 96.243  104.111 1.00 29.16  ? 218 PRO A CB   1 
ATOM   3584 C CG   . PRO B  1 218 ? 129.630 96.489  105.368 1.00 34.54  ? 218 PRO A CG   1 
ATOM   3585 C CD   . PRO B  1 218 ? 129.389 97.921  105.704 1.00 33.75  ? 218 PRO A CD   1 
ATOM   3586 N N    . ILE B  1 219 ? 126.572 98.144  103.429 1.00 32.09  ? 219 ILE A N    1 
ATOM   3587 C CA   . ILE B  1 219 ? 125.247 98.349  102.850 1.00 29.74  ? 219 ILE A CA   1 
ATOM   3588 C C    . ILE B  1 219 ? 125.239 99.585  101.960 1.00 31.92  ? 219 ILE A C    1 
ATOM   3589 O O    . ILE B  1 219 ? 124.746 99.555  100.828 1.00 36.30  ? 219 ILE A O    1 
ATOM   3590 C CB   . ILE B  1 219 ? 124.186 98.448  103.958 1.00 30.55  ? 219 ILE A CB   1 
ATOM   3591 C CG1  . ILE B  1 219 ? 124.252 97.220  104.863 1.00 33.84  ? 219 ILE A CG1  1 
ATOM   3592 C CG2  . ILE B  1 219 ? 122.806 98.578  103.352 1.00 25.71  ? 219 ILE A CG2  1 
ATOM   3593 C CD1  . ILE B  1 219 ? 124.074 95.918  104.128 1.00 34.15  ? 219 ILE A CD1  1 
ATOM   3594 N N    . GLU B  1 220 ? 125.781 100.689 102.461 1.00 35.42  ? 220 GLU A N    1 
ATOM   3595 C CA   . GLU B  1 220 ? 125.936 101.881 101.650 1.00 30.16  ? 220 GLU A CA   1 
ATOM   3596 C C    . GLU B  1 220 ? 127.212 101.781 100.819 1.00 37.87  ? 220 GLU A C    1 
ATOM   3597 O O    . GLU B  1 220 ? 128.025 100.871 100.984 1.00 46.24  ? 220 GLU A O    1 
ATOM   3598 C CB   . GLU B  1 220 ? 125.976 103.128 102.531 1.00 29.46  ? 220 GLU A CB   1 
ATOM   3599 C CG   . GLU B  1 220 ? 124.934 103.153 103.630 1.00 31.28  ? 220 GLU A CG   1 
ATOM   3600 C CD   . GLU B  1 220 ? 123.568 103.555 103.132 1.00 40.74  ? 220 GLU A CD   1 
ATOM   3601 O OE1  . GLU B  1 220 ? 123.445 103.898 101.940 1.00 46.87  ? 220 GLU A OE1  1 
ATOM   3602 O OE2  . GLU B  1 220 ? 122.614 103.533 103.935 1.00 40.26  ? 220 GLU A OE2  1 
ATOM   3603 N N    . GLY B  1 221 ? 127.380 102.730 99.908  1.00 41.19  ? 221 GLY A N    1 
ATOM   3604 C CA   . GLY B  1 221 ? 128.607 102.796 99.142  1.00 41.29  ? 221 GLY A CA   1 
ATOM   3605 C C    . GLY B  1 221 ? 129.609 103.745 99.760  1.00 44.20  ? 221 GLY A C    1 
ATOM   3606 O O    . GLY B  1 221 ? 130.280 104.502 99.053  1.00 50.31  ? 221 GLY A O    1 
ATOM   3607 N N    . TRP B  1 222 ? 129.721 103.716 101.084 1.00 30.29  ? 222 TRP A N    1 
ATOM   3608 C CA   . TRP B  1 222 ? 130.548 104.654 101.823 1.00 31.53  ? 222 TRP A CA   1 
ATOM   3609 C C    . TRP B  1 222 ? 131.852 103.998 102.251 1.00 37.36  ? 222 TRP A C    1 
ATOM   3610 O O    . TRP B  1 222 ? 131.948 102.773 102.353 1.00 46.13  ? 222 TRP A O    1 
ATOM   3611 C CB   . TRP B  1 222 ? 129.819 105.173 103.063 1.00 27.86  ? 222 TRP A CB   1 
ATOM   3612 C CG   . TRP B  1 222 ? 128.569 105.926 102.773 1.00 31.70  ? 222 TRP A CG   1 
ATOM   3613 C CD1  . TRP B  1 222 ? 128.135 106.359 101.558 1.00 32.53  ? 222 TRP A CD1  1 
ATOM   3614 C CD2  . TRP B  1 222 ? 127.581 106.337 103.722 1.00 31.37  ? 222 TRP A CD2  1 
ATOM   3615 N NE1  . TRP B  1 222 ? 126.939 107.016 101.690 1.00 31.81  ? 222 TRP A NE1  1 
ATOM   3616 C CE2  . TRP B  1 222 ? 126.577 107.015 103.011 1.00 27.84  ? 222 TRP A CE2  1 
ATOM   3617 C CE3  . TRP B  1 222 ? 127.450 106.195 105.105 1.00 28.32  ? 222 TRP A CE3  1 
ATOM   3618 C CZ2  . TRP B  1 222 ? 125.457 107.552 103.635 1.00 30.01  ? 222 TRP A CZ2  1 
ATOM   3619 C CZ3  . TRP B  1 222 ? 126.339 106.729 105.721 1.00 24.37  ? 222 TRP A CZ3  1 
ATOM   3620 C CH2  . TRP B  1 222 ? 125.357 107.398 104.988 1.00 28.15  ? 222 TRP A CH2  1 
ATOM   3621 N N    . SER B  1 223 ? 132.857 104.831 102.497 1.00 29.91  ? 223 SER A N    1 
ATOM   3622 C CA   . SER B  1 223 ? 134.079 104.370 103.130 1.00 26.50  ? 223 SER A CA   1 
ATOM   3623 C C    . SER B  1 223 ? 133.922 104.418 104.645 1.00 33.07  ? 223 SER A C    1 
ATOM   3624 O O    . SER B  1 223 ? 133.016 105.058 105.182 1.00 41.45  ? 223 SER A O    1 
ATOM   3625 C CB   . SER B  1 223 ? 135.269 105.221 102.694 1.00 33.62  ? 223 SER A CB   1 
ATOM   3626 O OG   . SER B  1 223 ? 135.067 106.581 103.030 1.00 38.19  ? 223 SER A OG   1 
ATOM   3627 N N    . TYR B  1 224 ? 134.826 103.727 105.341 1.00 29.93  ? 224 TYR A N    1 
ATOM   3628 C CA   . TYR B  1 224 ? 134.708 103.638 106.791 1.00 30.76  ? 224 TYR A CA   1 
ATOM   3629 C C    . TYR B  1 224 ? 134.794 105.014 107.439 1.00 37.18  ? 224 TYR A C    1 
ATOM   3630 O O    . TYR B  1 224 ? 134.025 105.327 108.358 1.00 39.52  ? 224 TYR A O    1 
ATOM   3631 C CB   . TYR B  1 224 ? 135.784 102.710 107.348 1.00 31.04  ? 224 TYR A CB   1 
ATOM   3632 C CG   . TYR B  1 224 ? 135.483 102.219 108.741 1.00 39.71  ? 224 TYR A CG   1 
ATOM   3633 C CD1  . TYR B  1 224 ? 134.725 101.078 108.945 1.00 40.72  ? 224 TYR A CD1  1 
ATOM   3634 C CD2  . TYR B  1 224 ? 135.948 102.902 109.853 1.00 38.26  ? 224 TYR A CD2  1 
ATOM   3635 C CE1  . TYR B  1 224 ? 134.443 100.629 110.215 1.00 38.55  ? 224 TYR A CE1  1 
ATOM   3636 C CE2  . TYR B  1 224 ? 135.671 102.460 111.127 1.00 34.88  ? 224 TYR A CE2  1 
ATOM   3637 C CZ   . TYR B  1 224 ? 134.919 101.323 111.302 1.00 38.70  ? 224 TYR A CZ   1 
ATOM   3638 O OH   . TYR B  1 224 ? 134.639 100.878 112.571 1.00 41.09  ? 224 TYR A OH   1 
ATOM   3639 N N    . PHE B  1 225 ? 135.721 105.851 106.974 1.00 36.77  ? 225 PHE A N    1 
ATOM   3640 C CA   . PHE B  1 225 ? 135.846 107.187 107.543 1.00 34.30  ? 225 PHE A CA   1 
ATOM   3641 C C    . PHE B  1 225 ? 134.589 108.010 107.300 1.00 37.04  ? 225 PHE A C    1 
ATOM   3642 O O    . PHE B  1 225 ? 134.162 108.774 108.171 1.00 43.40  ? 225 PHE A O    1 
ATOM   3643 C CB   . PHE B  1 225 ? 137.071 107.896 106.974 1.00 35.99  ? 225 PHE A CB   1 
ATOM   3644 C CG   . PHE B  1 225 ? 137.220 109.308 107.453 1.00 42.68  ? 225 PHE A CG   1 
ATOM   3645 C CD1  . PHE B  1 225 ? 137.445 109.575 108.791 1.00 38.90  ? 225 PHE A CD1  1 
ATOM   3646 C CD2  . PHE B  1 225 ? 137.129 110.367 106.571 1.00 38.90  ? 225 PHE A CD2  1 
ATOM   3647 C CE1  . PHE B  1 225 ? 137.576 110.870 109.238 1.00 34.19  ? 225 PHE A CE1  1 
ATOM   3648 C CE2  . PHE B  1 225 ? 137.261 111.664 107.013 1.00 36.24  ? 225 PHE A CE2  1 
ATOM   3649 C CZ   . PHE B  1 225 ? 137.485 111.915 108.348 1.00 38.81  ? 225 PHE A CZ   1 
ATOM   3650 N N    . ASP B  1 226 ? 133.986 107.876 106.119 1.00 27.26  ? 226 ASP A N    1 
ATOM   3651 C CA   . ASP B  1 226 ? 132.724 108.562 105.865 1.00 29.15  ? 226 ASP A CA   1 
ATOM   3652 C C    . ASP B  1 226 ? 131.640 108.075 106.815 1.00 35.46  ? 226 ASP A C    1 
ATOM   3653 O O    . ASP B  1 226 ? 130.811 108.863 107.280 1.00 42.41  ? 226 ASP A O    1 
ATOM   3654 C CB   . ASP B  1 226 ? 132.293 108.364 104.415 1.00 33.43  ? 226 ASP A CB   1 
ATOM   3655 C CG   . ASP B  1 226 ? 133.028 109.278 103.462 1.00 41.02  ? 226 ASP A CG   1 
ATOM   3656 O OD1  . ASP B  1 226 ? 133.857 110.082 103.932 1.00 43.08  ? 226 ASP A OD1  1 
ATOM   3657 O OD2  . ASP B  1 226 ? 132.773 109.196 102.243 1.00 41.23  ? 226 ASP A OD2  1 
ATOM   3658 N N    . SER B  1 227 ? 131.622 106.774 107.108 1.00 30.07  ? 227 SER A N    1 
ATOM   3659 C CA   . SER B  1 227 ? 130.648 106.251 108.059 1.00 28.51  ? 227 SER A CA   1 
ATOM   3660 C C    . SER B  1 227 ? 130.851 106.855 109.441 1.00 30.15  ? 227 SER A C    1 
ATOM   3661 O O    . SER B  1 227 ? 129.883 107.238 110.106 1.00 31.72  ? 227 SER A O    1 
ATOM   3662 C CB   . SER B  1 227 ? 130.739 104.729 108.118 1.00 32.03  ? 227 SER A CB   1 
ATOM   3663 O OG   . SER B  1 227 ? 130.459 104.154 106.856 1.00 34.03  ? 227 SER A OG   1 
ATOM   3664 N N    . LEU B  1 228 ? 132.103 106.952 109.893 1.00 29.03  ? 228 LEU A N    1 
ATOM   3665 C CA   . LEU B  1 228 ? 132.365 107.567 111.192 1.00 24.26  ? 228 LEU A CA   1 
ATOM   3666 C C    . LEU B  1 228 ? 131.954 109.034 111.202 1.00 24.69  ? 228 LEU A C    1 
ATOM   3667 O O    . LEU B  1 228 ? 131.391 109.527 112.188 1.00 32.87  ? 228 LEU A O    1 
ATOM   3668 C CB   . LEU B  1 228 ? 133.842 107.427 111.554 1.00 26.40  ? 228 LEU A CB   1 
ATOM   3669 C CG   . LEU B  1 228 ? 134.351 106.010 111.800 1.00 33.95  ? 228 LEU A CG   1 
ATOM   3670 C CD1  . LEU B  1 228 ? 135.843 106.025 112.054 1.00 31.73  ? 228 LEU A CD1  1 
ATOM   3671 C CD2  . LEU B  1 228 ? 133.618 105.386 112.968 1.00 34.55  ? 228 LEU A CD2  1 
ATOM   3672 N N    . TYR B  1 229 ? 132.247 109.751 110.118 1.00 21.06  ? 229 TYR A N    1 
ATOM   3673 C CA   . TYR B  1 229 ? 131.866 111.155 110.029 1.00 22.75  ? 229 TYR A CA   1 
ATOM   3674 C C    . TYR B  1 229 ? 130.354 111.317 110.099 1.00 26.57  ? 229 TYR A C    1 
ATOM   3675 O O    . TYR B  1 229 ? 129.846 112.187 110.819 1.00 23.45  ? 229 TYR A O    1 
ATOM   3676 C CB   . TYR B  1 229 ? 132.425 111.750 108.737 1.00 21.59  ? 229 TYR A CB   1 
ATOM   3677 C CG   . TYR B  1 229 ? 131.956 113.146 108.420 1.00 28.51  ? 229 TYR A CG   1 
ATOM   3678 C CD1  . TYR B  1 229 ? 132.462 114.241 109.101 1.00 23.17  ? 229 TYR A CD1  1 
ATOM   3679 C CD2  . TYR B  1 229 ? 131.024 113.372 107.421 1.00 28.96  ? 229 TYR A CD2  1 
ATOM   3680 C CE1  . TYR B  1 229 ? 132.040 115.517 108.806 1.00 20.53  ? 229 TYR A CE1  1 
ATOM   3681 C CE2  . TYR B  1 229 ? 130.598 114.643 107.120 1.00 30.66  ? 229 TYR A CE2  1 
ATOM   3682 C CZ   . TYR B  1 229 ? 131.109 115.712 107.814 1.00 27.45  ? 229 TYR A CZ   1 
ATOM   3683 O OH   . TYR B  1 229 ? 130.683 116.982 107.514 1.00 28.61  ? 229 TYR A OH   1 
ATOM   3684 N N    . PHE B  1 230 ? 129.616 110.480 109.369 1.00 23.09  ? 230 PHE A N    1 
ATOM   3685 C CA   . PHE B  1 230 ? 128.160 110.534 109.436 1.00 17.82  ? 230 PHE A CA   1 
ATOM   3686 C C    . PHE B  1 230 ? 127.664 110.204 110.833 1.00 23.76  ? 230 PHE A C    1 
ATOM   3687 O O    . PHE B  1 230 ? 126.722 110.832 111.329 1.00 25.64  ? 230 PHE A O    1 
ATOM   3688 C CB   . PHE B  1 230 ? 127.541 109.577 108.420 1.00 23.75  ? 230 PHE A CB   1 
ATOM   3689 C CG   . PHE B  1 230 ? 126.092 109.284 108.680 1.00 32.73  ? 230 PHE A CG   1 
ATOM   3690 C CD1  . PHE B  1 230 ? 125.113 110.187 108.314 1.00 27.70  ? 230 PHE A CD1  1 
ATOM   3691 C CD2  . PHE B  1 230 ? 125.710 108.110 109.301 1.00 28.16  ? 230 PHE A CD2  1 
ATOM   3692 C CE1  . PHE B  1 230 ? 123.783 109.921 108.558 1.00 23.49  ? 230 PHE A CE1  1 
ATOM   3693 C CE2  . PHE B  1 230 ? 124.382 107.842 109.546 1.00 20.64  ? 230 PHE A CE2  1 
ATOM   3694 C CZ   . PHE B  1 230 ? 123.418 108.749 109.174 1.00 21.91  ? 230 PHE A CZ   1 
ATOM   3695 N N    . CYS B  1 231 ? 128.269 109.207 111.479 1.00 30.14  ? 231 CYS A N    1 
ATOM   3696 C CA   . CYS B  1 231 ? 127.849 108.849 112.827 1.00 18.17  ? 231 CYS A CA   1 
ATOM   3697 C C    . CYS B  1 231 ? 128.020 110.024 113.775 1.00 23.12  ? 231 CYS A C    1 
ATOM   3698 O O    . CYS B  1 231 ? 127.120 110.338 114.560 1.00 32.03  ? 231 CYS A O    1 
ATOM   3699 C CB   . CYS B  1 231 ? 128.635 107.635 113.321 1.00 14.22  ? 231 CYS A CB   1 
ATOM   3700 S SG   . CYS B  1 231 ? 128.224 106.090 112.489 1.00 39.87  ? 231 CYS A SG   1 
ATOM   3701 N N    . PHE B  1 232 ? 129.167 110.698 113.711 1.00 24.39  ? 232 PHE A N    1 
ATOM   3702 C CA   . PHE B  1 232 ? 129.362 111.843 114.594 1.00 20.31  ? 232 PHE A CA   1 
ATOM   3703 C C    . PHE B  1 232 ? 128.387 112.967 114.272 1.00 20.36  ? 232 PHE A C    1 
ATOM   3704 O O    . PHE B  1 232 ? 127.830 113.589 115.183 1.00 26.81  ? 232 PHE A O    1 
ATOM   3705 C CB   . PHE B  1 232 ? 130.792 112.366 114.521 1.00 20.42  ? 232 PHE A CB   1 
ATOM   3706 C CG   . PHE B  1 232 ? 131.008 113.605 115.337 1.00 26.85  ? 232 PHE A CG   1 
ATOM   3707 C CD1  . PHE B  1 232 ? 131.227 113.518 116.700 1.00 27.07  ? 232 PHE A CD1  1 
ATOM   3708 C CD2  . PHE B  1 232 ? 130.955 114.856 114.753 1.00 24.84  ? 232 PHE A CD2  1 
ATOM   3709 C CE1  . PHE B  1 232 ? 131.411 114.654 117.459 1.00 22.93  ? 232 PHE A CE1  1 
ATOM   3710 C CE2  . PHE B  1 232 ? 131.137 115.995 115.509 1.00 23.96  ? 232 PHE A CE2  1 
ATOM   3711 C CZ   . PHE B  1 232 ? 131.365 115.893 116.863 1.00 24.20  ? 232 PHE A CZ   1 
ATOM   3712 N N    . VAL B  1 233 ? 128.174 113.251 112.988 1.00 26.34  ? 233 VAL A N    1 
ATOM   3713 C CA   . VAL B  1 233 ? 127.300 114.363 112.626 1.00 21.94  ? 233 VAL A CA   1 
ATOM   3714 C C    . VAL B  1 233 ? 125.869 114.094 113.076 1.00 24.37  ? 233 VAL A C    1 
ATOM   3715 O O    . VAL B  1 233 ? 125.177 114.998 113.557 1.00 21.63  ? 233 VAL A O    1 
ATOM   3716 C CB   . VAL B  1 233 ? 127.378 114.639 111.116 1.00 22.41  ? 233 VAL A CB   1 
ATOM   3717 C CG1  . VAL B  1 233 ? 126.307 115.627 110.711 1.00 14.63  ? 233 VAL A CG1  1 
ATOM   3718 C CG2  . VAL B  1 233 ? 128.749 115.170 110.757 1.00 22.49  ? 233 VAL A CG2  1 
ATOM   3719 N N    . ALA B  1 234 ? 125.397 112.855 112.922 1.00 27.97  ? 234 ALA A N    1 
ATOM   3720 C CA   . ALA B  1 234 ? 124.028 112.539 113.313 1.00 17.68  ? 234 ALA A CA   1 
ATOM   3721 C C    . ALA B  1 234 ? 123.879 112.466 114.827 1.00 24.06  ? 234 ALA A C    1 
ATOM   3722 O O    . ALA B  1 234 ? 122.899 112.973 115.384 1.00 32.70  ? 234 ALA A O    1 
ATOM   3723 C CB   . ALA B  1 234 ? 123.591 111.227 112.670 1.00 17.69  ? 234 ALA A CB   1 
ATOM   3724 N N    . PHE B  1 235 ? 124.837 111.839 115.512 1.00 27.60  ? 235 PHE A N    1 
ATOM   3725 C CA   . PHE B  1 235 ? 124.716 111.656 116.954 1.00 16.60  ? 235 PHE A CA   1 
ATOM   3726 C C    . PHE B  1 235 ? 124.722 112.991 117.688 1.00 22.50  ? 235 PHE A C    1 
ATOM   3727 O O    . PHE B  1 235 ? 123.958 113.187 118.639 1.00 25.63  ? 235 PHE A O    1 
ATOM   3728 C CB   . PHE B  1 235 ? 125.841 110.757 117.465 1.00 13.60  ? 235 PHE A CB   1 
ATOM   3729 C CG   . PHE B  1 235 ? 125.762 109.342 116.970 1.00 23.94  ? 235 PHE A CG   1 
ATOM   3730 C CD1  . PHE B  1 235 ? 124.680 108.910 116.228 1.00 25.16  ? 235 PHE A CD1  1 
ATOM   3731 C CD2  . PHE B  1 235 ? 126.769 108.440 117.257 1.00 24.18  ? 235 PHE A CD2  1 
ATOM   3732 C CE1  . PHE B  1 235 ? 124.608 107.611 115.776 1.00 22.28  ? 235 PHE A CE1  1 
ATOM   3733 C CE2  . PHE B  1 235 ? 126.700 107.139 116.808 1.00 16.56  ? 235 PHE A CE2  1 
ATOM   3734 C CZ   . PHE B  1 235 ? 125.619 106.725 116.067 1.00 20.61  ? 235 PHE A CZ   1 
ATOM   3735 N N    . SER B  1 236 ? 125.574 113.920 117.264 1.00 22.75  ? 236 SER A N    1 
ATOM   3736 C CA   . SER B  1 236 ? 125.645 115.223 117.912 1.00 22.34  ? 236 SER A CA   1 
ATOM   3737 C C    . SER B  1 236 ? 124.421 116.083 117.645 1.00 29.26  ? 236 SER A C    1 
ATOM   3738 O O    . SER B  1 236 ? 124.283 117.138 118.271 1.00 28.26  ? 236 SER A O    1 
ATOM   3739 C CB   . SER B  1 236 ? 126.904 115.962 117.463 1.00 21.75  ? 236 SER A CB   1 
ATOM   3740 O OG   . SER B  1 236 ? 126.930 116.110 116.057 1.00 20.74  ? 236 SER A OG   1 
ATOM   3741 N N    . THR B  1 237 ? 123.539 115.666 116.738 1.00 28.41  ? 237 THR A N    1 
ATOM   3742 C CA   . THR B  1 237 ? 122.326 116.404 116.396 1.00 22.57  ? 237 THR A CA   1 
ATOM   3743 C C    . THR B  1 237 ? 122.622 117.637 115.550 1.00 27.41  ? 237 THR A C    1 
ATOM   3744 O O    . THR B  1 237 ? 121.818 118.568 115.500 1.00 40.49  ? 237 THR A O    1 
ATOM   3745 C CB   . THR B  1 237 ? 121.530 116.804 117.642 1.00 27.75  ? 237 THR A CB   1 
ATOM   3746 O OG1  . THR B  1 237 ? 121.126 115.631 118.356 1.00 34.78  ? 237 THR A OG1  1 
ATOM   3747 C CG2  . THR B  1 237 ? 120.302 117.606 117.256 1.00 23.57  ? 237 THR A CG2  1 
ATOM   3748 N N    . ILE B  1 238 ? 123.773 117.661 114.883 1.00 20.21  ? 238 ILE A N    1 
ATOM   3749 C CA   . ILE B  1 238 ? 124.051 118.726 113.925 1.00 17.78  ? 238 ILE A CA   1 
ATOM   3750 C C    . ILE B  1 238 ? 123.283 118.485 112.633 1.00 27.46  ? 238 ILE A C    1 
ATOM   3751 O O    . ILE B  1 238 ? 122.542 119.353 112.158 1.00 40.08  ? 238 ILE A O    1 
ATOM   3752 C CB   . ILE B  1 238 ? 125.563 118.842 113.667 1.00 20.38  ? 238 ILE A CB   1 
ATOM   3753 C CG1  . ILE B  1 238 ? 126.301 119.174 114.961 1.00 24.67  ? 238 ILE A CG1  1 
ATOM   3754 C CG2  . ILE B  1 238 ? 125.841 119.903 112.626 1.00 11.48  ? 238 ILE A CG2  1 
ATOM   3755 C CD1  . ILE B  1 238 ? 127.787 119.323 114.786 1.00 15.44  ? 238 ILE A CD1  1 
ATOM   3756 N N    . GLY B  1 239 ? 123.437 117.298 112.057 1.00 21.52  ? 239 GLY A N    1 
ATOM   3757 C CA   . GLY B  1 239 ? 122.664 116.912 110.894 1.00 8.65   ? 239 GLY A CA   1 
ATOM   3758 C C    . GLY B  1 239 ? 122.801 117.751 109.644 1.00 23.79  ? 239 GLY A C    1 
ATOM   3759 O O    . GLY B  1 239 ? 121.806 118.259 109.120 1.00 37.54  ? 239 GLY A O    1 
ATOM   3760 N N    . PHE B  1 240 ? 124.030 117.910 109.152 1.00 23.72  ? 240 PHE A N    1 
ATOM   3761 C CA   . PHE B  1 240 ? 124.231 118.653 107.913 1.00 15.94  ? 240 PHE A CA   1 
ATOM   3762 C C    . PHE B  1 240 ? 123.313 118.215 106.781 1.00 26.33  ? 240 PHE A C    1 
ATOM   3763 O O    . PHE B  1 240 ? 122.731 119.053 106.085 1.00 35.21  ? 240 PHE A O    1 
ATOM   3764 C CB   . PHE B  1 240 ? 125.691 118.576 107.474 1.00 20.43  ? 240 PHE A CB   1 
ATOM   3765 C CG   . PHE B  1 240 ? 126.626 119.365 108.337 1.00 20.94  ? 240 PHE A CG   1 
ATOM   3766 C CD1  . PHE B  1 240 ? 126.221 120.554 108.908 1.00 24.05  ? 240 PHE A CD1  1 
ATOM   3767 C CD2  . PHE B  1 240 ? 127.911 118.918 108.577 1.00 18.39  ? 240 PHE A CD2  1 
ATOM   3768 C CE1  . PHE B  1 240 ? 127.079 121.281 109.701 1.00 25.82  ? 240 PHE A CE1  1 
ATOM   3769 C CE2  . PHE B  1 240 ? 128.770 119.641 109.370 1.00 22.78  ? 240 PHE A CE2  1 
ATOM   3770 C CZ   . PHE B  1 240 ? 128.355 120.824 109.932 1.00 21.86  ? 240 PHE A CZ   1 
ATOM   3771 N N    . GLY B  1 241 ? 123.168 116.908 106.586 1.00 27.83  ? 241 GLY A N    1 
ATOM   3772 C CA   . GLY B  1 241 ? 122.340 116.378 105.526 1.00 23.83  ? 241 GLY A CA   1 
ATOM   3773 C C    . GLY B  1 241 ? 123.082 115.950 104.282 1.00 31.45  ? 241 GLY A C    1 
ATOM   3774 O O    . GLY B  1 241 ? 122.456 115.403 103.367 1.00 37.78  ? 241 GLY A O    1 
ATOM   3775 N N    . ASP B  1 242 ? 124.395 116.183 104.212 1.00 30.61  ? 242 ASP A N    1 
ATOM   3776 C CA   . ASP B  1 242 ? 125.157 115.737 103.051 1.00 26.36  ? 242 ASP A CA   1 
ATOM   3777 C C    . ASP B  1 242 ? 125.167 114.218 102.950 1.00 34.81  ? 242 ASP A C    1 
ATOM   3778 O O    . ASP B  1 242 ? 125.075 113.661 101.850 1.00 39.76  ? 242 ASP A O    1 
ATOM   3779 C CB   . ASP B  1 242 ? 126.581 116.287 103.115 1.00 26.00  ? 242 ASP A CB   1 
ATOM   3780 C CG   . ASP B  1 242 ? 127.238 116.047 104.454 1.00 42.09  ? 242 ASP A CG   1 
ATOM   3781 O OD1  . ASP B  1 242 ? 126.509 115.845 105.446 1.00 44.84  ? 242 ASP A OD1  1 
ATOM   3782 O OD2  . ASP B  1 242 ? 128.484 116.066 104.519 1.00 43.01  ? 242 ASP A OD2  1 
ATOM   3783 N N    . LEU B  1 243 ? 125.278 113.531 104.083 1.00 33.83  ? 243 LEU A N    1 
ATOM   3784 C CA   . LEU B  1 243 ? 125.213 112.076 104.137 1.00 28.87  ? 243 LEU A CA   1 
ATOM   3785 C C    . LEU B  1 243 ? 123.995 111.677 104.955 1.00 31.58  ? 243 LEU A C    1 
ATOM   3786 O O    . LEU B  1 243 ? 123.865 112.078 106.116 1.00 39.08  ? 243 LEU A O    1 
ATOM   3787 C CB   . LEU B  1 243 ? 126.485 111.487 104.747 1.00 30.39  ? 243 LEU A CB   1 
ATOM   3788 C CG   . LEU B  1 243 ? 127.781 111.675 103.962 1.00 32.80  ? 243 LEU A CG   1 
ATOM   3789 C CD1  . LEU B  1 243 ? 128.940 111.052 104.712 1.00 31.40  ? 243 LEU A CD1  1 
ATOM   3790 C CD2  . LEU B  1 243 ? 127.654 111.070 102.578 1.00 31.48  ? 243 LEU A CD2  1 
ATOM   3791 N N    . VAL B  1 244 ? 123.110 110.890 104.353 1.00 29.08  ? 244 VAL A N    1 
ATOM   3792 C CA   . VAL B  1 244 ? 121.925 110.371 105.022 1.00 27.96  ? 244 VAL A CA   1 
ATOM   3793 C C    . VAL B  1 244 ? 121.782 108.900 104.665 1.00 30.36  ? 244 VAL A C    1 
ATOM   3794 O O    . VAL B  1 244 ? 121.966 108.513 103.506 1.00 33.99  ? 244 VAL A O    1 
ATOM   3795 C CB   . VAL B  1 244 ? 120.656 111.153 104.631 1.00 27.18  ? 244 VAL A CB   1 
ATOM   3796 C CG1  . VAL B  1 244 ? 119.450 110.588 105.350 1.00 27.95  ? 244 VAL A CG1  1 
ATOM   3797 C CG2  . VAL B  1 244 ? 120.826 112.623 104.948 1.00 29.30  ? 244 VAL A CG2  1 
ATOM   3798 N N    . SER B  1 245 ? 121.455 108.082 105.658 1.00 26.08  ? 245 SER A N    1 
ATOM   3799 C CA   . SER B  1 245 ? 121.377 106.641 105.486 1.00 25.97  ? 245 SER A CA   1 
ATOM   3800 C C    . SER B  1 245 ? 119.941 106.202 105.237 1.00 33.89  ? 245 SER A C    1 
ATOM   3801 O O    . SER B  1 245 ? 118.987 106.856 105.664 1.00 35.57  ? 245 SER A O    1 
ATOM   3802 C CB   . SER B  1 245 ? 121.928 105.921 106.715 1.00 24.98  ? 245 SER A CB   1 
ATOM   3803 O OG   . SER B  1 245 ? 121.170 106.241 107.865 1.00 32.22  ? 245 SER A OG   1 
ATOM   3804 N N    . SER B  1 246 ? 119.799 105.073 104.544 1.00 33.00  ? 246 SER A N    1 
ATOM   3805 C CA   . SER B  1 246 ? 118.491 104.481 104.273 1.00 30.00  ? 246 SER A CA   1 
ATOM   3806 C C    . SER B  1 246 ? 117.655 105.382 103.362 1.00 31.96  ? 246 SER A C    1 
ATOM   3807 O O    . SER B  1 246 ? 116.525 105.746 103.685 1.00 36.70  ? 246 SER A O    1 
ATOM   3808 C CB   . SER B  1 246 ? 117.748 104.179 105.575 1.00 32.04  ? 246 SER A CB   1 
ATOM   3809 O OG   . SER B  1 246 ? 116.501 103.564 105.315 1.00 42.03  ? 246 SER A OG   1 
ATOM   3810 N N    . GLN B  1 247 ? 118.223 105.739 102.213 1.00 40.80  ? 247 GLN A N    1 
ATOM   3811 C CA   . GLN B  1 247 ? 117.553 106.600 101.245 1.00 33.07  ? 247 GLN A CA   1 
ATOM   3812 C C    . GLN B  1 247 ? 117.760 106.081 99.830  1.00 33.00  ? 247 GLN A C    1 
ATOM   3813 O O    . GLN B  1 247 ? 117.873 106.858 98.878  1.00 44.58  ? 247 GLN A O    1 
ATOM   3814 C CB   . GLN B  1 247 ? 118.052 108.040 101.354 1.00 29.81  ? 247 GLN A CB   1 
ATOM   3815 C CG   . GLN B  1 247 ? 117.877 108.666 102.722 1.00 28.46  ? 247 GLN A CG   1 
ATOM   3816 C CD   . GLN B  1 247 ? 116.499 109.248 102.922 1.00 38.62  ? 247 GLN A CD   1 
ATOM   3817 O OE1  . GLN B  1 247 ? 115.797 109.555 101.961 1.00 50.00  ? 247 GLN A OE1  1 
ATOM   3818 N NE2  . GLN B  1 247 ? 116.100 109.406 104.177 1.00 40.20  ? 247 GLN A NE2  1 
ATOM   3819 N N    . ASN B  1 248 ? 117.811 104.761 99.663  1.00 33.43  ? 248 ASN A N    1 
ATOM   3820 C CA   . ASN B  1 248 ? 118.153 104.161 98.378  1.00 34.19  ? 248 ASN A CA   1 
ATOM   3821 C C    . ASN B  1 248 ? 117.038 103.276 97.835  1.00 41.86  ? 248 ASN A C    1 
ATOM   3822 O O    . ASN B  1 248 ? 117.304 102.304 97.126  1.00 53.08  ? 248 ASN A O    1 
ATOM   3823 C CB   . ASN B  1 248 ? 119.450 103.361 98.481  1.00 38.10  ? 248 ASN A CB   1 
ATOM   3824 C CG   . ASN B  1 248 ? 120.680 104.227 98.343  1.00 42.87  ? 248 ASN A CG   1 
ATOM   3825 O OD1  . ASN B  1 248 ? 120.618 105.330 97.803  1.00 46.08  ? 248 ASN A OD1  1 
ATOM   3826 N ND2  . ASN B  1 248 ? 121.810 103.728 98.822  1.00 44.20  ? 248 ASN A ND2  1 
ATOM   3827 N N    . ALA B  1 249 ? 115.787 103.628 98.153  1.00 38.71  ? 249 ALA A N    1 
ATOM   3828 C CA   . ALA B  1 249 ? 114.632 102.798 97.731  1.00 40.62  ? 249 ALA A CA   1 
ATOM   3829 C C    . ALA B  1 249 ? 114.886 101.346 98.148  1.00 47.01  ? 249 ALA A C    1 
ATOM   3830 O O    . ALA B  1 249 ? 114.942 101.088 99.367  1.00 53.26  ? 249 ALA A O    1 
ATOM   3831 C CB   . ALA B  1 249 ? 114.398 102.924 96.244  1.00 35.81  ? 249 ALA A CB   1 
ATOM   3832 N N    . HIS B  1 250 ? 115.043 100.436 97.181  1.00 45.82  ? 250 HIS A N    1 
ATOM   3833 C CA   . HIS B  1 250 ? 115.362 99.059  97.532  1.00 47.17  ? 250 HIS A CA   1 
ATOM   3834 C C    . HIS B  1 250 ? 116.666 98.900  98.305  1.00 43.96  ? 250 HIS A C    1 
ATOM   3835 O O    . HIS B  1 250 ? 117.711 99.406  97.888  1.00 39.55  ? 250 HIS A O    1 
ATOM   3836 C CB   . HIS B  1 250 ? 115.378 98.195  96.275  1.00 46.47  ? 250 HIS A CB   1 
ATOM   3837 C CG   . HIS B  1 250 ? 115.374 96.726  96.553  1.00 49.67  ? 250 HIS A CG   1 
ATOM   3838 N ND1  . HIS B  1 250 ? 116.414 95.898  96.190  1.00 50.90  ? 250 HIS A ND1  1 
ATOM   3839 C CD2  . HIS B  1 250 ? 114.458 95.935  97.159  1.00 46.54  ? 250 HIS A CD2  1 
ATOM   3840 C CE1  . HIS B  1 250 ? 116.138 94.660  96.560  1.00 51.73  ? 250 HIS A CE1  1 
ATOM   3841 N NE2  . HIS B  1 250 ? 114.956 94.656  97.150  1.00 50.61  ? 250 HIS A NE2  1 
ATOM   3842 N N    . TYR B  1 251 ? 116.574 98.215  99.454  1.00 44.15  ? 251 TYR A N    1 
ATOM   3843 C CA   . TYR B  1 251 ? 117.753 98.025  100.337 1.00 40.74  ? 251 TYR A CA   1 
ATOM   3844 C C    . TYR B  1 251 ? 117.891 96.547  100.705 1.00 40.58  ? 251 TYR A C    1 
ATOM   3845 O O    . TYR B  1 251 ? 118.124 96.252  101.895 1.00 42.79  ? 251 TYR A O    1 
ATOM   3846 C CB   . TYR B  1 251 ? 117.582 98.840  101.617 1.00 45.51  ? 251 TYR A CB   1 
ATOM   3847 C CG   . TYR B  1 251 ? 118.482 100.043 101.694 1.00 40.79  ? 251 TYR A CG   1 
ATOM   3848 C CD1  . TYR B  1 251 ? 119.850 99.895  101.835 1.00 32.54  ? 251 TYR A CD1  1 
ATOM   3849 C CD2  . TYR B  1 251 ? 117.966 101.323 101.605 1.00 39.77  ? 251 TYR A CD2  1 
ATOM   3850 C CE1  . TYR B  1 251 ? 120.689 100.993 101.898 1.00 38.43  ? 251 TYR A CE1  1 
ATOM   3851 C CE2  . TYR B  1 251 ? 118.791 102.431 101.668 1.00 31.39  ? 251 TYR A CE2  1 
ATOM   3852 C CZ   . TYR B  1 251 ? 120.154 102.264 101.815 1.00 37.84  ? 251 TYR A CZ   1 
ATOM   3853 O OH   . TYR B  1 251 ? 120.976 103.354 101.874 1.00 44.38  ? 251 TYR A OH   1 
ATOM   3854 N N    . GLU B  1 252 ? 117.730 95.656  99.725  1.00 48.18  ? 252 GLU A N    1 
ATOM   3855 C CA   . GLU B  1 252 ? 117.851 94.215  99.958  1.00 48.25  ? 252 GLU A CA   1 
ATOM   3856 C C    . GLU B  1 252 ? 116.858 93.972  101.089 1.00 53.60  ? 252 GLU A C    1 
ATOM   3857 O O    . GLU B  1 252 ? 115.668 94.283  100.912 1.00 57.31  ? 252 GLU A O    1 
ATOM   3858 C CB   . GLU B  1 252 ? 119.309 93.881  100.269 1.00 46.97  ? 252 GLU A CB   1 
ATOM   3859 C CG   . GLU B  1 252 ? 119.571 92.397  100.417 1.00 50.57  ? 252 GLU A CG   1 
ATOM   3860 C CD   . GLU B  1 252 ? 119.240 91.624  99.157  1.00 55.80  ? 252 GLU A CD   1 
ATOM   3861 O OE1  . GLU B  1 252 ? 118.976 92.265  98.118  1.00 53.56  ? 252 GLU A OE1  1 
ATOM   3862 O OE2  . GLU B  1 252 ? 119.243 90.378  99.204  1.00 56.44  ? 252 GLU A OE2  1 
ATOM   3863 N N    . SER B  1 253 ? 117.257 93.384  102.214 1.00 49.52  ? 253 SER A N    1 
ATOM   3864 C CA   . SER B  1 253 ? 116.301 93.088  103.278 1.00 46.24  ? 253 SER A CA   1 
ATOM   3865 C C    . SER B  1 253 ? 115.358 94.253  103.553 1.00 50.72  ? 253 SER A C    1 
ATOM   3866 O O    . SER B  1 253 ? 114.146 94.158  103.333 1.00 52.29  ? 253 SER A O    1 
ATOM   3867 C CB   . SER B  1 253 ? 117.039 92.673  104.548 1.00 43.70  ? 253 SER A CB   1 
ATOM   3868 O OG   . SER B  1 253 ? 116.125 92.309  105.566 1.00 52.38  ? 253 SER A OG   1 
ATOM   3869 N N    . GLN B  1 254 ? 115.903 95.364  104.044 1.00 45.69  ? 254 GLN A N    1 
ATOM   3870 C CA   . GLN B  1 254 ? 115.156 96.609  104.175 1.00 43.15  ? 254 GLN A CA   1 
ATOM   3871 C C    . GLN B  1 254 ? 114.142 96.548  105.307 1.00 45.88  ? 254 GLN A C    1 
ATOM   3872 O O    . GLN B  1 254 ? 113.534 97.565  105.654 1.00 49.70  ? 254 GLN A O    1 
ATOM   3873 C CB   . GLN B  1 254 ? 114.450 96.948  102.862 1.00 37.82  ? 254 GLN A CB   1 
ATOM   3874 C CG   . GLN B  1 254 ? 113.796 98.312  102.855 1.00 43.08  ? 254 GLN A CG   1 
ATOM   3875 C CD   . GLN B  1 254 ? 113.095 98.612  101.551 1.00 46.60  ? 254 GLN A CD   1 
ATOM   3876 O OE1  . GLN B  1 254 ? 112.623 97.707  100.866 1.00 51.50  ? 254 GLN A OE1  1 
ATOM   3877 N NE2  . GLN B  1 254 ? 113.029 99.887  101.197 1.00 46.05  ? 254 GLN A NE2  1 
ATOM   3878 N N    . GLY B  1 255 ? 113.955 95.373  105.893 1.00 44.98  ? 255 GLY A N    1 
ATOM   3879 C CA   . GLY B  1 255 ? 113.082 95.259  107.040 1.00 38.65  ? 255 GLY A CA   1 
ATOM   3880 C C    . GLY B  1 255 ? 113.863 95.419  108.324 1.00 41.63  ? 255 GLY A C    1 
ATOM   3881 O O    . GLY B  1 255 ? 113.525 96.249  109.172 1.00 46.76  ? 255 GLY A O    1 
ATOM   3882 N N    . LEU B  1 256 ? 114.923 94.628  108.468 1.00 38.02  ? 256 LEU A N    1 
ATOM   3883 C CA   . LEU B  1 256 ? 115.799 94.756  109.623 1.00 34.69  ? 256 LEU A CA   1 
ATOM   3884 C C    . LEU B  1 256 ? 116.711 95.968  109.511 1.00 33.09  ? 256 LEU A C    1 
ATOM   3885 O O    . LEU B  1 256 ? 117.147 96.502  110.535 1.00 40.37  ? 256 LEU A O    1 
ATOM   3886 C CB   . LEU B  1 256 ? 116.640 93.492  109.795 1.00 32.75  ? 256 LEU A CB   1 
ATOM   3887 C CG   . LEU B  1 256 ? 115.899 92.191  110.100 1.00 37.17  ? 256 LEU A CG   1 
ATOM   3888 C CD1  . LEU B  1 256 ? 115.105 91.715  108.895 1.00 37.71  ? 256 LEU A CD1  1 
ATOM   3889 C CD2  . LEU B  1 256 ? 116.879 91.128  110.552 1.00 40.17  ? 256 LEU A CD2  1 
ATOM   3890 N N    . TYR B  1 257 ? 117.020 96.407  108.291 1.00 26.96  ? 257 TYR A N    1 
ATOM   3891 C CA   . TYR B  1 257 ? 117.950 97.517  108.128 1.00 26.36  ? 257 TYR A CA   1 
ATOM   3892 C C    . TYR B  1 257 ? 117.403 98.795  108.751 1.00 34.25  ? 257 TYR A C    1 
ATOM   3893 O O    . TYR B  1 257 ? 118.130 99.519  109.439 1.00 34.50  ? 257 TYR A O    1 
ATOM   3894 C CB   . TYR B  1 257 ? 118.262 97.731  106.649 1.00 26.42  ? 257 TYR A CB   1 
ATOM   3895 C CG   . TYR B  1 257 ? 119.299 98.798  106.406 1.00 33.49  ? 257 TYR A CG   1 
ATOM   3896 C CD1  . TYR B  1 257 ? 120.650 98.510  106.493 1.00 35.95  ? 257 TYR A CD1  1 
ATOM   3897 C CD2  . TYR B  1 257 ? 118.927 100.094 106.096 1.00 30.35  ? 257 TYR A CD2  1 
ATOM   3898 C CE1  . TYR B  1 257 ? 121.600 99.482  106.277 1.00 32.94  ? 257 TYR A CE1  1 
ATOM   3899 C CE2  . TYR B  1 257 ? 119.870 101.072 105.880 1.00 28.37  ? 257 TYR A CE2  1 
ATOM   3900 C CZ   . TYR B  1 257 ? 121.204 100.761 105.971 1.00 32.18  ? 257 TYR A CZ   1 
ATOM   3901 O OH   . TYR B  1 257 ? 122.146 101.736 105.753 1.00 36.77  ? 257 TYR A OH   1 
ATOM   3902 N N    . ARG B  1 258 ? 116.121 99.089  108.525 1.00 32.51  ? 258 ARG A N    1 
ATOM   3903 C CA   . ARG B  1 258 ? 115.532 100.294 109.098 1.00 25.79  ? 258 ARG A CA   1 
ATOM   3904 C C    . ARG B  1 258 ? 115.484 100.220 110.618 1.00 30.22  ? 258 ARG A C    1 
ATOM   3905 O O    . ARG B  1 258 ? 115.765 101.210 111.304 1.00 37.02  ? 258 ARG A O    1 
ATOM   3906 C CB   . ARG B  1 258 ? 114.139 100.516 108.517 1.00 29.07  ? 258 ARG A CB   1 
ATOM   3907 C CG   . ARG B  1 258 ? 114.152 100.811 107.030 1.00 31.09  ? 258 ARG A CG   1 
ATOM   3908 C CD   . ARG B  1 258 ? 112.753 100.917 106.462 1.00 31.56  ? 258 ARG A CD   1 
ATOM   3909 N NE   . ARG B  1 258 ? 112.775 101.345 105.070 1.00 34.08  ? 258 ARG A NE   1 
ATOM   3910 C CZ   . ARG B  1 258 ? 111.703 101.427 104.295 1.00 33.62  ? 258 ARG A CZ   1 
ATOM   3911 N NH1  . ARG B  1 258 ? 110.504 101.096 104.737 1.00 38.87  ? 258 ARG A NH1  1 
ATOM   3912 N NH2  . ARG B  1 258 ? 111.841 101.848 103.042 1.00 30.99  ? 258 ARG A NH2  1 
ATOM   3913 N N    . PHE B  1 259 ? 115.130 99.056  111.164 1.00 32.36  ? 259 PHE A N    1 
ATOM   3914 C CA   . PHE B  1 259 ? 115.115 98.892  112.613 1.00 30.18  ? 259 PHE A CA   1 
ATOM   3915 C C    . PHE B  1 259 ? 116.506 99.093  113.203 1.00 31.60  ? 259 PHE A C    1 
ATOM   3916 O O    . PHE B  1 259 ? 116.667 99.773  114.225 1.00 35.23  ? 259 PHE A O    1 
ATOM   3917 C CB   . PHE B  1 259 ? 114.565 97.511  112.964 1.00 24.55  ? 259 PHE A CB   1 
ATOM   3918 C CG   . PHE B  1 259 ? 114.663 97.166  114.417 1.00 33.96  ? 259 PHE A CG   1 
ATOM   3919 C CD1  . PHE B  1 259 ? 113.842 97.776  115.344 1.00 34.65  ? 259 PHE A CD1  1 
ATOM   3920 C CD2  . PHE B  1 259 ? 115.565 96.216  114.853 1.00 32.11  ? 259 PHE A CD2  1 
ATOM   3921 C CE1  . PHE B  1 259 ? 113.929 97.456  116.679 1.00 33.02  ? 259 PHE A CE1  1 
ATOM   3922 C CE2  . PHE B  1 259 ? 115.656 95.892  116.187 1.00 32.07  ? 259 PHE A CE2  1 
ATOM   3923 C CZ   . PHE B  1 259 ? 114.836 96.512  117.102 1.00 31.12  ? 259 PHE A CZ   1 
ATOM   3924 N N    . ALA B  1 260 ? 117.525 98.515  112.566 1.00 30.09  ? 260 ALA A N    1 
ATOM   3925 C CA   . ALA B  1 260 ? 118.891 98.680  113.045 1.00 28.16  ? 260 ALA A CA   1 
ATOM   3926 C C    . ALA B  1 260 ? 119.327 100.136 112.975 1.00 27.85  ? 260 ALA A C    1 
ATOM   3927 O O    . ALA B  1 260 ? 119.982 100.640 113.892 1.00 38.36  ? 260 ALA A O    1 
ATOM   3928 C CB   . ALA B  1 260 ? 119.839 97.796  112.237 1.00 28.89  ? 260 ALA A CB   1 
ATOM   3929 N N    . ASN B  1 261 ? 118.979 100.826 111.888 1.00 30.11  ? 261 ASN A N    1 
ATOM   3930 C CA   . ASN B  1 261 ? 119.320 102.238 111.774 1.00 33.95  ? 261 ASN A CA   1 
ATOM   3931 C C    . ASN B  1 261 ? 118.664 103.047 112.885 1.00 29.24  ? 261 ASN A C    1 
ATOM   3932 O O    . ASN B  1 261 ? 119.309 103.899 113.512 1.00 32.16  ? 261 ASN A O    1 
ATOM   3933 C CB   . ASN B  1 261 ? 118.899 102.759 110.402 1.00 29.50  ? 261 ASN A CB   1 
ATOM   3934 C CG   . ASN B  1 261 ? 119.334 104.183 110.161 1.00 32.98  ? 261 ASN A CG   1 
ATOM   3935 O OD1  . ASN B  1 261 ? 120.279 104.667 110.779 1.00 41.69  ? 261 ASN A OD1  1 
ATOM   3936 N ND2  . ASN B  1 261 ? 118.645 104.865 109.257 1.00 29.28  ? 261 ASN A ND2  1 
ATOM   3937 N N    . PHE B  1 262 ? 117.385 102.782 113.150 1.00 24.71  ? 262 PHE A N    1 
ATOM   3938 C CA   . PHE B  1 262 ? 116.683 103.477 114.224 1.00 30.73  ? 262 PHE A CA   1 
ATOM   3939 C C    . PHE B  1 262 ? 117.376 103.254 115.561 1.00 35.79  ? 262 PHE A C    1 
ATOM   3940 O O    . PHE B  1 262 ? 117.642 104.205 116.307 1.00 32.00  ? 262 PHE A O    1 
ATOM   3941 C CB   . PHE B  1 262 ? 115.231 102.998 114.271 1.00 27.77  ? 262 PHE A CB   1 
ATOM   3942 C CG   . PHE B  1 262 ? 114.441 103.539 115.427 1.00 34.98  ? 262 PHE A CG   1 
ATOM   3943 C CD1  . PHE B  1 262 ? 113.818 104.769 115.342 1.00 35.51  ? 262 PHE A CD1  1 
ATOM   3944 C CD2  . PHE B  1 262 ? 114.300 102.805 116.589 1.00 34.23  ? 262 PHE A CD2  1 
ATOM   3945 C CE1  . PHE B  1 262 ? 113.085 105.262 116.399 1.00 31.57  ? 262 PHE A CE1  1 
ATOM   3946 C CE2  . PHE B  1 262 ? 113.567 103.295 117.649 1.00 27.99  ? 262 PHE A CE2  1 
ATOM   3947 C CZ   . PHE B  1 262 ? 112.960 104.524 117.553 1.00 26.16  ? 262 PHE A CZ   1 
ATOM   3948 N N    . VAL B  1 263 ? 117.695 101.995 115.874 1.00 38.05  ? 263 VAL A N    1 
ATOM   3949 C CA   . VAL B  1 263 ? 118.306 101.679 117.163 1.00 27.87  ? 263 VAL A CA   1 
ATOM   3950 C C    . VAL B  1 263 ? 119.663 102.359 117.293 1.00 30.00  ? 263 VAL A C    1 
ATOM   3951 O O    . VAL B  1 263 ? 119.989 102.948 118.333 1.00 40.66  ? 263 VAL A O    1 
ATOM   3952 C CB   . VAL B  1 263 ? 118.422 100.156 117.338 1.00 26.28  ? 263 VAL A CB   1 
ATOM   3953 C CG1  . VAL B  1 263 ? 119.247 99.831  118.563 1.00 33.00  ? 263 VAL A CG1  1 
ATOM   3954 C CG2  . VAL B  1 263 ? 117.044 99.538  117.445 1.00 30.87  ? 263 VAL A CG2  1 
ATOM   3955 N N    . PHE B  1 264 ? 120.483 102.276 116.243 1.00 25.77  ? 264 PHE A N    1 
ATOM   3956 C CA   . PHE B  1 264 ? 121.817 102.860 116.302 1.00 22.93  ? 264 PHE A CA   1 
ATOM   3957 C C    . PHE B  1 264 ? 121.747 104.366 116.499 1.00 22.39  ? 264 PHE A C    1 
ATOM   3958 O O    . PHE B  1 264 ? 122.471 104.928 117.330 1.00 30.37  ? 264 PHE A O    1 
ATOM   3959 C CB   . PHE B  1 264 ? 122.597 102.518 115.035 1.00 26.91  ? 264 PHE A CB   1 
ATOM   3960 C CG   . PHE B  1 264 ? 123.199 101.146 115.048 1.00 35.31  ? 264 PHE A CG   1 
ATOM   3961 C CD1  . PHE B  1 264 ? 123.778 100.642 116.196 1.00 31.87  ? 264 PHE A CD1  1 
ATOM   3962 C CD2  . PHE B  1 264 ? 123.184 100.360 113.913 1.00 29.88  ? 264 PHE A CD2  1 
ATOM   3963 C CE1  . PHE B  1 264 ? 124.332 99.383  116.211 1.00 28.76  ? 264 PHE A CE1  1 
ATOM   3964 C CE2  . PHE B  1 264 ? 123.736 99.099  113.923 1.00 28.07  ? 264 PHE A CE2  1 
ATOM   3965 C CZ   . PHE B  1 264 ? 124.311 98.610  115.074 1.00 32.25  ? 264 PHE A CZ   1 
ATOM   3966 N N    . ILE B  1 265 ? 120.877 105.040 115.745 1.00 28.80  ? 265 ILE A N    1 
ATOM   3967 C CA   . ILE B  1 265 ? 120.779 106.490 115.879 1.00 28.64  ? 265 ILE A CA   1 
ATOM   3968 C C    . ILE B  1 265 ? 120.296 106.865 117.272 1.00 29.74  ? 265 ILE A C    1 
ATOM   3969 O O    . ILE B  1 265 ? 120.811 107.806 117.889 1.00 33.06  ? 265 ILE A O    1 
ATOM   3970 C CB   . ILE B  1 265 ? 119.874 107.076 114.783 1.00 30.82  ? 265 ILE A CB   1 
ATOM   3971 C CG1  . ILE B  1 265 ? 120.511 106.873 113.409 1.00 26.83  ? 265 ILE A CG1  1 
ATOM   3972 C CG2  . ILE B  1 265 ? 119.634 108.550 115.032 1.00 31.15  ? 265 ILE A CG2  1 
ATOM   3973 C CD1  . ILE B  1 265 ? 119.806 107.606 112.299 1.00 26.89  ? 265 ILE A CD1  1 
ATOM   3974 N N    . LEU B  1 266 ? 119.305 106.140 117.795 1.00 27.43  ? 266 LEU A N    1 
ATOM   3975 C CA   . LEU B  1 266 ? 118.805 106.436 119.134 1.00 25.15  ? 266 LEU A CA   1 
ATOM   3976 C C    . LEU B  1 266 ? 119.911 106.316 120.177 1.00 28.61  ? 266 LEU A C    1 
ATOM   3977 O O    . LEU B  1 266 ? 120.127 107.231 120.988 1.00 28.14  ? 266 LEU A O    1 
ATOM   3978 C CB   . LEU B  1 266 ? 117.644 105.501 119.467 1.00 26.80  ? 266 LEU A CB   1 
ATOM   3979 C CG   . LEU B  1 266 ? 117.046 105.586 120.868 1.00 26.39  ? 266 LEU A CG   1 
ATOM   3980 C CD1  . LEU B  1 266 ? 116.396 106.935 121.087 1.00 28.53  ? 266 LEU A CD1  1 
ATOM   3981 C CD2  . LEU B  1 266 ? 116.047 104.468 121.078 1.00 22.41  ? 266 LEU A CD2  1 
ATOM   3982 N N    . MET B  1 267 ? 120.628 105.189 120.170 1.00 27.57  ? 267 MET A N    1 
ATOM   3983 C CA   . MET B  1 267 ? 121.669 104.983 121.171 1.00 26.41  ? 267 MET A CA   1 
ATOM   3984 C C    . MET B  1 267 ? 122.774 106.021 121.042 1.00 33.27  ? 267 MET A C    1 
ATOM   3985 O O    . MET B  1 267 ? 123.255 106.559 122.050 1.00 43.69  ? 267 MET A O    1 
ATOM   3986 C CB   . MET B  1 267 ? 122.242 103.571 121.056 1.00 26.68  ? 267 MET A CB   1 
ATOM   3987 C CG   . MET B  1 267 ? 121.231 102.475 121.319 1.00 32.44  ? 267 MET A CG   1 
ATOM   3988 S SD   . MET B  1 267 ? 122.004 100.872 121.583 1.00 54.95  ? 267 MET A SD   1 
ATOM   3989 C CE   . MET B  1 267 ? 122.929 100.688 120.065 1.00 40.66  ? 267 MET A CE   1 
ATOM   3990 N N    . GLY B  1 268 ? 123.196 106.317 119.812 1.00 25.85  ? 268 GLY A N    1 
ATOM   3991 C CA   . GLY B  1 268 ? 124.236 107.311 119.627 1.00 20.44  ? 268 GLY A CA   1 
ATOM   3992 C C    . GLY B  1 268 ? 123.821 108.682 120.119 1.00 22.98  ? 268 GLY A C    1 
ATOM   3993 O O    . GLY B  1 268 ? 124.605 109.384 120.764 1.00 24.44  ? 268 GLY A O    1 
ATOM   3994 N N    . VAL B  1 269 ? 122.584 109.085 119.823 1.00 25.79  ? 269 VAL A N    1 
ATOM   3995 C CA   . VAL B  1 269 ? 122.110 110.388 120.274 1.00 25.70  ? 269 VAL A CA   1 
ATOM   3996 C C    . VAL B  1 269 ? 122.117 110.453 121.793 1.00 29.16  ? 269 VAL A C    1 
ATOM   3997 O O    . VAL B  1 269 ? 122.580 111.433 122.388 1.00 40.21  ? 269 VAL A O    1 
ATOM   3998 C CB   . VAL B  1 269 ? 120.714 110.684 119.702 1.00 32.18  ? 269 VAL A CB   1 
ATOM   3999 C CG1  . VAL B  1 269 ? 120.196 111.997 120.250 1.00 30.77  ? 269 VAL A CG1  1 
ATOM   4000 C CG2  . VAL B  1 269 ? 120.762 110.726 118.190 1.00 30.71  ? 269 VAL A CG2  1 
ATOM   4001 N N    . CYS B  1 270 ? 121.612 109.404 122.448 1.00 34.79  ? 270 CYS A N    1 
ATOM   4002 C CA   . CYS B  1 270 ? 121.601 109.405 123.909 1.00 31.29  ? 270 CYS A CA   1 
ATOM   4003 C C    . CYS B  1 270 ? 123.013 109.538 124.470 1.00 32.44  ? 270 CYS A C    1 
ATOM   4004 O O    . CYS B  1 270 ? 123.277 110.382 125.341 1.00 41.43  ? 270 CYS A O    1 
ATOM   4005 C CB   . CYS B  1 270 ? 120.934 108.134 124.432 1.00 30.34  ? 270 CYS A CB   1 
ATOM   4006 S SG   . CYS B  1 270 ? 119.152 108.062 124.171 1.00 57.72  ? 270 CYS A SG   1 
ATOM   4007 N N    . CYS B  1 271 ? 123.938 108.713 123.974 1.00 24.74  ? 271 CYS A N    1 
ATOM   4008 C CA   . CYS B  1 271 ? 125.290 108.724 124.520 1.00 25.77  ? 271 CYS A CA   1 
ATOM   4009 C C    . CYS B  1 271 ? 125.967 110.071 124.304 1.00 31.52  ? 271 CYS A C    1 
ATOM   4010 O O    . CYS B  1 271 ? 126.612 110.602 125.215 1.00 38.57  ? 271 CYS A O    1 
ATOM   4011 C CB   . CYS B  1 271 ? 126.117 107.598 123.902 1.00 31.86  ? 271 CYS A CB   1 
ATOM   4012 S SG   . CYS B  1 271 ? 125.575 105.944 124.374 1.00 56.02  ? 271 CYS A SG   1 
ATOM   4013 N N    . ILE B  1 272 ? 125.830 110.646 123.107 1.00 27.93  ? 272 ILE A N    1 
ATOM   4014 C CA   . ILE B  1 272 ? 126.506 111.908 122.827 1.00 29.30  ? 272 ILE A CA   1 
ATOM   4015 C C    . ILE B  1 272 ? 125.894 113.043 123.636 1.00 31.26  ? 272 ILE A C    1 
ATOM   4016 O O    . ILE B  1 272 ? 126.605 113.941 124.098 1.00 32.09  ? 272 ILE A O    1 
ATOM   4017 C CB   . ILE B  1 272 ? 126.486 112.208 121.321 1.00 29.57  ? 272 ILE A CB   1 
ATOM   4018 C CG1  . ILE B  1 272 ? 127.360 111.202 120.576 1.00 26.72  ? 272 ILE A CG1  1 
ATOM   4019 C CG2  . ILE B  1 272 ? 126.978 113.613 121.063 1.00 24.20  ? 272 ILE A CG2  1 
ATOM   4020 C CD1  . ILE B  1 272 ? 128.802 111.218 121.011 1.00 23.37  ? 272 ILE A CD1  1 
ATOM   4021 N N    . TYR B  1 273 ? 124.572 113.035 123.819 1.00 31.70  ? 273 TYR A N    1 
ATOM   4022 C CA   . TYR B  1 273 ? 123.940 114.057 124.647 1.00 29.13  ? 273 TYR A CA   1 
ATOM   4023 C C    . TYR B  1 273 ? 124.474 114.003 126.074 1.00 37.56  ? 273 TYR A C    1 
ATOM   4024 O O    . TYR B  1 273 ? 124.847 115.034 126.659 1.00 38.44  ? 273 TYR A O    1 
ATOM   4025 C CB   . TYR B  1 273 ? 122.424 113.862 124.619 1.00 29.58  ? 273 TYR A CB   1 
ATOM   4026 C CG   . TYR B  1 273 ? 121.626 114.909 125.355 1.00 41.62  ? 273 TYR A CG   1 
ATOM   4027 C CD1  . TYR B  1 273 ? 121.317 114.755 126.697 1.00 39.54  ? 273 TYR A CD1  1 
ATOM   4028 C CD2  . TYR B  1 273 ? 121.163 116.041 124.702 1.00 41.79  ? 273 TYR A CD2  1 
ATOM   4029 C CE1  . TYR B  1 273 ? 120.582 115.705 127.372 1.00 39.01  ? 273 TYR A CE1  1 
ATOM   4030 C CE2  . TYR B  1 273 ? 120.426 116.996 125.368 1.00 40.72  ? 273 TYR A CE2  1 
ATOM   4031 C CZ   . TYR B  1 273 ? 120.139 116.823 126.703 1.00 47.90  ? 273 TYR A CZ   1 
ATOM   4032 O OH   . TYR B  1 273 ? 119.406 117.773 127.372 1.00 51.80  ? 273 TYR A OH   1 
ATOM   4033 N N    . SER B  1 274 ? 124.538 112.799 126.647 1.00 37.45  ? 274 SER A N    1 
ATOM   4034 C CA   . SER B  1 274 ? 125.067 112.667 127.999 1.00 31.17  ? 274 SER A CA   1 
ATOM   4035 C C    . SER B  1 274 ? 126.521 113.123 128.069 1.00 32.16  ? 274 SER A C    1 
ATOM   4036 O O    . SER B  1 274 ? 126.923 113.812 129.019 1.00 43.56  ? 274 SER A O    1 
ATOM   4037 C CB   . SER B  1 274 ? 124.930 111.223 128.472 1.00 35.29  ? 274 SER A CB   1 
ATOM   4038 O OG   . SER B  1 274 ? 123.587 110.789 128.373 1.00 40.50  ? 274 SER A OG   1 
ATOM   4039 N N    . LEU B  1 275 ? 127.324 112.744 127.074 1.00 29.54  ? 275 LEU A N    1 
ATOM   4040 C CA   . LEU B  1 275 ? 128.727 113.144 127.066 1.00 32.71  ? 275 LEU A CA   1 
ATOM   4041 C C    . LEU B  1 275 ? 128.868 114.658 127.016 1.00 36.02  ? 275 LEU A C    1 
ATOM   4042 O O    . LEU B  1 275 ? 129.703 115.237 127.721 1.00 38.48  ? 275 LEU A O    1 
ATOM   4043 C CB   . LEU B  1 275 ? 129.445 112.499 125.884 1.00 27.04  ? 275 LEU A CB   1 
ATOM   4044 C CG   . LEU B  1 275 ? 130.940 112.776 125.757 1.00 30.45  ? 275 LEU A CG   1 
ATOM   4045 C CD1  . LEU B  1 275 ? 131.676 112.272 126.980 1.00 29.06  ? 275 LEU A CD1  1 
ATOM   4046 C CD2  . LEU B  1 275 ? 131.488 112.137 124.497 1.00 29.72  ? 275 LEU A CD2  1 
ATOM   4047 N N    . PHE B  1 276 ? 128.060 115.320 126.186 1.00 31.39  ? 276 PHE A N    1 
ATOM   4048 C CA   . PHE B  1 276 ? 128.127 116.773 126.103 1.00 20.42  ? 276 PHE A CA   1 
ATOM   4049 C C    . PHE B  1 276 ? 127.777 117.416 127.437 1.00 25.45  ? 276 PHE A C    1 
ATOM   4050 O O    . PHE B  1 276 ? 128.441 118.367 127.867 1.00 30.80  ? 276 PHE A O    1 
ATOM   4051 C CB   . PHE B  1 276 ? 127.202 117.287 125.002 1.00 24.14  ? 276 PHE A CB   1 
ATOM   4052 C CG   . PHE B  1 276 ? 127.772 117.150 123.622 1.00 29.74  ? 276 PHE A CG   1 
ATOM   4053 C CD1  . PHE B  1 276 ? 129.049 116.659 123.434 1.00 30.28  ? 276 PHE A CD1  1 
ATOM   4054 C CD2  . PHE B  1 276 ? 127.036 117.525 122.514 1.00 26.00  ? 276 PHE A CD2  1 
ATOM   4055 C CE1  . PHE B  1 276 ? 129.577 116.537 122.167 1.00 26.99  ? 276 PHE A CE1  1 
ATOM   4056 C CE2  . PHE B  1 276 ? 127.561 117.405 121.247 1.00 25.05  ? 276 PHE A CE2  1 
ATOM   4057 C CZ   . PHE B  1 276 ? 128.833 116.910 121.075 1.00 24.12  ? 276 PHE A CZ   1 
ATOM   4058 N N    . ASN B  1 277 ? 126.740 116.915 128.111 1.00 33.49  ? 277 ASN A N    1 
ATOM   4059 C CA   . ASN B  1 277 ? 126.384 117.502 129.401 1.00 25.92  ? 277 ASN A CA   1 
ATOM   4060 C C    . ASN B  1 277 ? 127.502 117.326 130.426 1.00 29.55  ? 277 ASN A C    1 
ATOM   4061 O O    . ASN B  1 277 ? 127.834 118.263 131.172 1.00 38.69  ? 277 ASN A O    1 
ATOM   4062 C CB   . ASN B  1 277 ? 125.077 116.900 129.908 1.00 27.59  ? 277 ASN A CB   1 
ATOM   4063 C CG   . ASN B  1 277 ? 123.874 117.417 129.150 1.00 38.44  ? 277 ASN A CG   1 
ATOM   4064 O OD1  . ASN B  1 277 ? 123.198 118.344 129.595 1.00 27.07  ? 277 ASN A OD1  1 
ATOM   4065 N ND2  . ASN B  1 277 ? 123.607 116.832 127.992 1.00 43.84  ? 277 ASN A ND2  1 
ATOM   4066 N N    . VAL B  1 278 ? 128.106 116.137 130.475 1.00 28.09  ? 278 VAL A N    1 
ATOM   4067 C CA   . VAL B  1 278 ? 129.191 115.914 131.430 1.00 27.94  ? 278 VAL A CA   1 
ATOM   4068 C C    . VAL B  1 278 ? 130.372 116.829 131.125 1.00 33.97  ? 278 VAL A C    1 
ATOM   4069 O O    . VAL B  1 278 ? 130.990 117.405 132.036 1.00 38.28  ? 278 VAL A O    1 
ATOM   4070 C CB   . VAL B  1 278 ? 129.604 114.433 131.434 1.00 31.98  ? 278 VAL A CB   1 
ATOM   4071 C CG1  . VAL B  1 278 ? 130.818 114.233 132.313 1.00 37.67  ? 278 VAL A CG1  1 
ATOM   4072 C CG2  . VAL B  1 278 ? 128.453 113.573 131.915 1.00 30.42  ? 278 VAL A CG2  1 
ATOM   4073 N N    . ILE B  1 279 ? 130.712 116.976 129.844 1.00 31.35  ? 279 ILE A N    1 
ATOM   4074 C CA   . ILE B  1 279 ? 131.825 117.845 129.478 1.00 26.80  ? 279 ILE A CA   1 
ATOM   4075 C C    . ILE B  1 279 ? 131.514 119.288 129.846 1.00 32.19  ? 279 ILE A C    1 
ATOM   4076 O O    . ILE B  1 279 ? 132.408 120.049 130.233 1.00 37.80  ? 279 ILE A O    1 
ATOM   4077 C CB   . ILE B  1 279 ? 132.155 117.698 127.984 1.00 28.44  ? 279 ILE A CB   1 
ATOM   4078 C CG1  . ILE B  1 279 ? 132.701 116.301 127.699 1.00 27.47  ? 279 ILE A CG1  1 
ATOM   4079 C CG2  . ILE B  1 279 ? 133.154 118.753 127.561 1.00 29.11  ? 279 ILE A CG2  1 
ATOM   4080 C CD1  . ILE B  1 279 ? 133.097 116.086 126.262 1.00 26.44  ? 279 ILE A CD1  1 
ATOM   4081 N N    . SER B  1 280 ? 130.250 119.695 129.722 1.00 33.94  ? 280 SER A N    1 
ATOM   4082 C CA   . SER B  1 280 ? 129.877 121.045 130.135 1.00 25.26  ? 280 SER A CA   1 
ATOM   4083 C C    . SER B  1 280 ? 130.096 121.239 131.629 1.00 29.07  ? 280 SER A C    1 
ATOM   4084 O O    . SER B  1 280 ? 130.575 122.294 132.063 1.00 34.12  ? 280 SER A O    1 
ATOM   4085 C CB   . SER B  1 280 ? 128.425 121.330 129.763 1.00 23.90  ? 280 SER A CB   1 
ATOM   4086 O OG   . SER B  1 280 ? 127.541 120.542 130.536 1.00 34.91  ? 280 SER A OG   1 
ATOM   4087 N N    . ILE B  1 281 ? 129.747 120.236 132.433 1.00 34.84  ? 281 ILE A N    1 
ATOM   4088 C CA   . ILE B  1 281 ? 130.001 120.340 133.871 1.00 34.39  ? 281 ILE A CA   1 
ATOM   4089 C C    . ILE B  1 281 ? 131.496 120.492 134.140 1.00 36.93  ? 281 ILE A C    1 
ATOM   4090 O O    . ILE B  1 281 ? 131.922 121.322 134.962 1.00 43.87  ? 281 ILE A O    1 
ATOM   4091 C CB   . ILE B  1 281 ? 129.417 119.127 134.612 1.00 35.35  ? 281 ILE A CB   1 
ATOM   4092 C CG1  . ILE B  1 281 ? 127.892 119.148 134.548 1.00 34.75  ? 281 ILE A CG1  1 
ATOM   4093 C CG2  . ILE B  1 281 ? 129.889 119.112 136.050 1.00 35.02  ? 281 ILE A CG2  1 
ATOM   4094 C CD1  . ILE B  1 281 ? 127.241 118.005 135.285 1.00 38.42  ? 281 ILE A CD1  1 
ATOM   4095 N N    . LEU B  1 282 ? 132.315 119.689 133.460 1.00 29.90  ? 282 LEU A N    1 
ATOM   4096 C CA   . LEU B  1 282 ? 133.760 119.797 133.653 1.00 32.98  ? 282 LEU A CA   1 
ATOM   4097 C C    . LEU B  1 282 ? 134.272 121.179 133.257 1.00 34.91  ? 282 LEU A C    1 
ATOM   4098 O O    . LEU B  1 282 ? 135.132 121.752 133.937 1.00 38.74  ? 282 LEU A O    1 
ATOM   4099 C CB   . LEU B  1 282 ? 134.482 118.712 132.859 1.00 37.48  ? 282 LEU A CB   1 
ATOM   4100 C CG   . LEU B  1 282 ? 134.441 117.308 133.458 1.00 37.31  ? 282 LEU A CG   1 
ATOM   4101 C CD1  . LEU B  1 282 ? 135.221 116.346 132.590 1.00 37.59  ? 282 LEU A CD1  1 
ATOM   4102 C CD2  . LEU B  1 282 ? 134.994 117.322 134.866 1.00 33.92  ? 282 LEU A CD2  1 
ATOM   4103 N N    . ILE B  1 283 ? 133.759 121.727 132.155 1.00 35.68  ? 283 ILE A N    1 
ATOM   4104 C CA   . ILE B  1 283 ? 134.189 123.052 131.717 1.00 31.03  ? 283 ILE A CA   1 
ATOM   4105 C C    . ILE B  1 283 ? 133.794 124.106 132.741 1.00 30.47  ? 283 ILE A C    1 
ATOM   4106 O O    . ILE B  1 283 ? 134.530 125.070 132.976 1.00 35.33  ? 283 ILE A O    1 
ATOM   4107 C CB   . ILE B  1 283 ? 133.614 123.374 130.327 1.00 27.14  ? 283 ILE A CB   1 
ATOM   4108 C CG1  . ILE B  1 283 ? 134.242 122.472 129.266 1.00 31.26  ? 283 ILE A CG1  1 
ATOM   4109 C CG2  . ILE B  1 283 ? 133.846 124.827 129.984 1.00 26.61  ? 283 ILE A CG2  1 
ATOM   4110 C CD1  . ILE B  1 283 ? 133.756 122.756 127.870 1.00 31.13  ? 283 ILE A CD1  1 
ATOM   4111 N N    . LYS B  1 284 ? 132.618 123.955 133.352 1.00 33.90  ? 284 LYS A N    1 
ATOM   4112 C CA   . LYS B  1 284 ? 132.211 124.895 134.391 1.00 32.18  ? 284 LYS A CA   1 
ATOM   4113 C C    . LYS B  1 284 ? 133.170 124.851 135.573 1.00 32.77  ? 284 LYS A C    1 
ATOM   4114 O O    . LYS B  1 284 ? 133.559 125.896 136.113 1.00 36.15  ? 284 LYS A O    1 
ATOM   4115 C CB   . LYS B  1 284 ? 130.785 124.589 134.844 1.00 27.16  ? 284 LYS A CB   1 
ATOM   4116 C CG   . LYS B  1 284 ? 130.265 125.505 135.929 1.00 27.97  ? 284 LYS A CG   1 
ATOM   4117 C CD   . LYS B  1 284 ? 128.869 125.094 136.353 1.00 35.57  ? 284 LYS A CD   1 
ATOM   4118 C CE   . LYS B  1 284 ? 128.328 126.005 137.434 1.00 35.57  ? 284 LYS A CE   1 
ATOM   4119 N NZ   . LYS B  1 284 ? 128.207 127.406 136.956 1.00 36.04  ? 284 LYS A NZ   1 
ATOM   4120 N N    . GLN B  1 285 ? 133.568 123.647 135.988 1.00 37.86  ? 285 GLN A N    1 
ATOM   4121 C CA   . GLN B  1 285 ? 134.548 123.548 137.067 1.00 35.80  ? 285 GLN A CA   1 
ATOM   4122 C C    . GLN B  1 285 ? 135.866 124.205 136.677 1.00 39.42  ? 285 GLN A C    1 
ATOM   4123 O O    . GLN B  1 285 ? 136.502 124.886 137.493 1.00 40.50  ? 285 GLN A O    1 
ATOM   4124 C CB   . GLN B  1 285 ? 134.768 122.086 137.451 1.00 36.93  ? 285 GLN A CB   1 
ATOM   4125 C CG   . GLN B  1 285 ? 133.571 121.439 138.119 1.00 43.67  ? 285 GLN A CG   1 
ATOM   4126 C CD   . GLN B  1 285 ? 133.869 120.038 138.606 1.00 52.89  ? 285 GLN A CD   1 
ATOM   4127 O OE1  . GLN B  1 285 ? 135.002 119.566 138.516 1.00 53.84  ? 285 GLN A OE1  1 
ATOM   4128 N NE2  . GLN B  1 285 ? 132.850 119.363 139.124 1.00 50.08  ? 285 GLN A NE2  1 
ATOM   4129 N N    . SER B  1 286 ? 136.296 124.008 135.430 1.00 40.05  ? 286 SER A N    1 
ATOM   4130 C CA   . SER B  1 286 ? 137.537 124.628 134.973 1.00 32.16  ? 286 SER A CA   1 
ATOM   4131 C C    . SER B  1 286 ? 137.442 126.149 135.000 1.00 38.22  ? 286 SER A C    1 
ATOM   4132 O O    . SER B  1 286 ? 138.402 126.832 135.374 1.00 42.35  ? 286 SER A O    1 
ATOM   4133 C CB   . SER B  1 286 ? 137.879 124.135 133.569 1.00 37.96  ? 286 SER A CB   1 
ATOM   4134 O OG   . SER B  1 286 ? 136.795 124.350 132.685 1.00 42.59  ? 286 SER A OG   1 
ATOM   4135 N N    . LEU B  1 287 ? 136.300 126.700 134.585 1.00 42.33  ? 287 LEU A N    1 
ATOM   4136 C CA   . LEU B  1 287 ? 136.118 128.148 134.640 1.00 34.08  ? 287 LEU A CA   1 
ATOM   4137 C C    . LEU B  1 287 ? 136.170 128.654 136.074 1.00 35.06  ? 287 LEU A C    1 
ATOM   4138 O O    . LEU B  1 287 ? 136.764 129.705 136.350 1.00 38.24  ? 287 LEU A O    1 
ATOM   4139 C CB   . LEU B  1 287 ? 134.794 128.546 133.990 1.00 34.83  ? 287 LEU A CB   1 
ATOM   4140 C CG   . LEU B  1 287 ? 134.714 128.500 132.466 1.00 33.06  ? 287 LEU A CG   1 
ATOM   4141 C CD1  . LEU B  1 287 ? 133.346 128.959 132.008 1.00 33.64  ? 287 LEU A CD1  1 
ATOM   4142 C CD2  . LEU B  1 287 ? 135.798 129.359 131.854 1.00 35.75  ? 287 LEU A CD2  1 
ATOM   4143 N N    . ASN B  1 288 ? 135.525 127.985 137.017 1.00 45.70  ? 288 ASN A N    1 
ATOM   4144 C CA   . ASN B  1 288 ? 135.665 128.449 138.416 1.00 41.38  ? 288 ASN A CA   1 
ATOM   4145 C C    . ASN B  1 288 ? 137.151 128.431 138.757 1.00 44.47  ? 288 ASN A C    1 
ATOM   4146 O O    . ASN B  1 288 ? 137.636 129.428 139.273 1.00 45.12  ? 288 ASN A O    1 
ATOM   4147 C CB   . ASN B  1 288 ? 134.876 127.599 139.397 1.00 42.00  ? 288 ASN A CB   1 
ATOM   4148 C CG   . ASN B  1 288 ? 133.384 127.785 139.293 1.00 47.01  ? 288 ASN A CG   1 
ATOM   4149 O OD1  . ASN B  1 288 ? 132.854 128.788 139.754 1.00 54.27  ? 288 ASN A OD1  1 
ATOM   4150 N ND2  . ASN B  1 288 ? 132.701 126.817 138.710 1.00 47.41  ? 288 ASN A ND2  1 
ATOM   4151 N N    . TRP B  1 289 ? 137.845 127.329 138.496 1.00 48.02  ? 289 TRP A N    1 
ATOM   4152 C CA   . TRP B  1 289 ? 139.252 127.309 138.885 1.00 46.93  ? 289 TRP A CA   1 
ATOM   4153 C C    . TRP B  1 289 ? 140.007 128.490 138.293 1.00 48.78  ? 289 TRP A C    1 
ATOM   4154 O O    . TRP B  1 289 ? 140.836 129.109 138.972 1.00 54.66  ? 289 TRP A O    1 
ATOM   4155 C CB   . TRP B  1 289 ? 139.909 126.000 138.458 1.00 51.79  ? 289 TRP A CB   1 
ATOM   4156 C CG   . TRP B  1 289 ? 141.375 125.963 138.761 1.00 54.73  ? 289 TRP A CG   1 
ATOM   4157 C CD1  . TRP B  1 289 ? 141.955 125.663 139.957 1.00 51.93  ? 289 TRP A CD1  1 
ATOM   4158 C CD2  . TRP B  1 289 ? 142.448 126.242 137.854 1.00 55.68  ? 289 TRP A CD2  1 
ATOM   4159 N NE1  . TRP B  1 289 ? 143.322 125.735 139.852 1.00 48.01  ? 289 TRP A NE1  1 
ATOM   4160 C CE2  . TRP B  1 289 ? 143.649 126.089 138.570 1.00 51.76  ? 289 TRP A CE2  1 
ATOM   4161 C CE3  . TRP B  1 289 ? 142.508 126.605 136.507 1.00 53.32  ? 289 TRP A CE3  1 
ATOM   4162 C CZ2  . TRP B  1 289 ? 144.896 126.285 137.985 1.00 52.64  ? 289 TRP A CZ2  1 
ATOM   4163 C CZ3  . TRP B  1 289 ? 143.747 126.799 135.928 1.00 52.73  ? 289 TRP A CZ3  1 
ATOM   4164 C CH2  . TRP B  1 289 ? 144.923 126.639 136.666 1.00 53.56  ? 289 TRP A CH2  1 
ATOM   4165 N N    . ILE B  1 290 ? 139.748 128.811 137.025 1.00 53.97  ? 290 ILE A N    1 
ATOM   4166 C CA   . ILE B  1 290 ? 140.442 129.931 136.392 1.00 52.94  ? 290 ILE A CA   1 
ATOM   4167 C C    . ILE B  1 290 ? 140.140 131.224 137.137 1.00 52.17  ? 290 ILE A C    1 
ATOM   4168 O O    . ILE B  1 290 ? 141.040 132.019 137.429 1.00 50.31  ? 290 ILE A O    1 
ATOM   4169 C CB   . ILE B  1 290 ? 140.056 130.044 134.908 1.00 51.99  ? 290 ILE A CB   1 
ATOM   4170 C CG1  . ILE B  1 290 ? 140.601 128.860 134.114 1.00 54.17  ? 290 ILE A CG1  1 
ATOM   4171 C CG2  . ILE B  1 290 ? 140.575 131.344 134.329 1.00 50.52  ? 290 ILE A CG2  1 
ATOM   4172 C CD1  . ILE B  1 290 ? 140.323 128.954 132.632 1.00 50.49  ? 290 ILE A CD1  1 
ATOM   4173 N N    . LEU B  1 291 ? 138.865 131.452 137.457 1.00 56.81  ? 291 LEU A N    1 
ATOM   4174 C CA   . LEU B  1 291 ? 138.502 132.663 138.185 1.00 51.50  ? 291 LEU A CA   1 
ATOM   4175 C C    . LEU B  1 291 ? 139.160 132.696 139.557 1.00 52.44  ? 291 LEU A C    1 
ATOM   4176 O O    . LEU B  1 291 ? 139.677 133.735 139.982 1.00 54.06  ? 291 LEU A O    1 
ATOM   4177 C CB   . LEU B  1 291 ? 136.985 132.766 138.319 1.00 48.53  ? 291 LEU A CB   1 
ATOM   4178 C CG   . LEU B  1 291 ? 136.226 133.088 137.035 1.00 47.83  ? 291 LEU A CG   1 
ATOM   4179 C CD1  . LEU B  1 291 ? 134.734 133.080 137.290 1.00 49.95  ? 291 LEU A CD1  1 
ATOM   4180 C CD2  . LEU B  1 291 ? 136.671 134.432 136.497 1.00 48.38  ? 291 LEU A CD2  1 
ATOM   4181 N N    . ARG B  1 292 ? 139.155 131.565 140.264 1.00 65.48  ? 292 ARG A N    1 
ATOM   4182 C CA   . ARG B  1 292 ? 139.739 131.529 141.600 1.00 64.60  ? 292 ARG A CA   1 
ATOM   4183 C C    . ARG B  1 292 ? 141.231 131.827 141.558 1.00 64.50  ? 292 ARG A C    1 
ATOM   4184 O O    . ARG B  1 292 ? 141.750 132.565 142.403 1.00 64.12  ? 292 ARG A O    1 
ATOM   4185 C CB   . ARG B  1 292 ? 139.475 130.168 142.240 1.00 65.40  ? 292 ARG A CB   1 
ATOM   4186 C CG   . ARG B  1 292 ? 139.607 130.141 143.748 1.00 66.93  ? 292 ARG A CG   1 
ATOM   4187 C CD   . ARG B  1 292 ? 139.022 128.854 144.297 1.00 68.09  ? 292 ARG A CD   1 
ATOM   4188 N NE   . ARG B  1 292 ? 137.644 128.666 143.859 1.00 71.65  ? 292 ARG A NE   1 
ATOM   4189 C CZ   . ARG B  1 292 ? 136.930 127.568 144.071 1.00 71.10  ? 292 ARG A CZ   1 
ATOM   4190 N NH1  . ARG B  1 292 ? 137.438 126.527 144.709 1.00 68.05  ? 292 ARG A NH1  1 
ATOM   4191 N NH2  . ARG B  1 292 ? 135.677 127.514 143.630 1.00 67.32  ? 292 ARG A NH2  1 
ATOM   4192 N N    . LYS B  1 293 ? 141.941 131.259 140.580 1.00 72.19  ? 293 LYS A N    1 
ATOM   4193 C CA   . LYS B  1 293 ? 143.372 131.515 140.467 1.00 75.15  ? 293 LYS A CA   1 
ATOM   4194 C C    . LYS B  1 293 ? 143.649 132.993 140.228 1.00 74.36  ? 293 LYS A C    1 
ATOM   4195 O O    . LYS B  1 293 ? 144.543 133.574 140.852 1.00 76.01  ? 293 LYS A O    1 
ATOM   4196 C CB   . LYS B  1 293 ? 143.967 130.670 139.341 1.00 74.22  ? 293 LYS A CB   1 
ATOM   4197 C CG   . LYS B  1 293 ? 145.434 130.941 139.066 1.00 73.94  ? 293 LYS A CG   1 
ATOM   4198 C CD   . LYS B  1 293 ? 146.272 130.731 140.314 1.00 73.71  ? 293 LYS A CD   1 
ATOM   4199 C CE   . LYS B  1 293 ? 146.000 129.372 140.933 1.00 73.42  ? 293 LYS A CE   1 
ATOM   4200 N NZ   . LYS B  1 293 ? 146.238 128.267 139.967 1.00 73.02  ? 293 LYS A NZ   1 
ATOM   4201 N N    . MET B  1 294 ? 142.894 133.615 139.329 1.00 79.24  ? 294 MET A N    1 
ATOM   4202 C CA   . MET B  1 294 ? 143.084 135.029 139.041 1.00 78.60  ? 294 MET A CA   1 
ATOM   4203 C C    . MET B  1 294 ? 142.664 135.877 140.234 1.00 80.59  ? 294 MET A C    1 
ATOM   4204 O O    . MET B  1 294 ? 141.627 135.633 140.855 1.00 80.80  ? 294 MET A O    1 
ATOM   4205 C CB   . MET B  1 294 ? 142.281 135.424 137.803 1.00 78.30  ? 294 MET A CB   1 
ATOM   4206 C CG   . MET B  1 294 ? 142.440 136.872 137.388 1.00 78.69  ? 294 MET A CG   1 
ATOM   4207 S SD   . MET B  1 294 ? 141.347 137.299 136.020 1.00 90.31  ? 294 MET A SD   1 
ATOM   4208 C CE   . MET B  1 294 ? 141.798 136.046 134.823 1.00 77.72  ? 294 MET A CE   1 
ATOM   4209 N N    . ASP B  1 295 ? 143.477 136.879 140.550 1.00 88.60  ? 295 ASP A N    1 
ATOM   4210 C CA   . ASP B  1 295 ? 143.197 137.773 141.669 1.00 89.77  ? 295 ASP A CA   1 
ATOM   4211 C C    . ASP B  1 295 ? 144.155 138.959 141.677 1.00 90.39  ? 295 ASP A C    1 
ATOM   4212 O O    . ASP B  1 295 ? 143.887 139.982 142.307 1.00 91.66  ? 295 ASP A O    1 
ATOM   4213 C CB   . ASP B  1 295 ? 143.288 137.018 142.998 1.00 87.29  ? 295 ASP A CB   1 
ATOM   4214 C CG   . ASP B  1 295 ? 141.929 136.604 143.527 1.00 88.11  ? 295 ASP A CG   1 
ATOM   4215 O OD1  . ASP B  1 295 ? 140.908 136.980 142.915 1.00 85.39  ? 295 ASP A OD1  1 
ATOM   4216 O OD2  . ASP B  1 295 ? 141.880 135.902 144.558 1.00 90.23  ? 295 ASP A OD2  1 
HETATM 4217 C C1   . D12 C  2 .   ? 131.418 141.023 118.673 1.00 20.00  ? 401 D12 U C1   1 
HETATM 4218 C C2   . D12 C  2 .   ? 130.922 140.324 117.409 1.00 20.00  ? 401 D12 U C2   1 
HETATM 4219 C C3   . D12 C  2 .   ? 132.070 139.747 116.589 1.00 20.00  ? 401 D12 U C3   1 
HETATM 4220 C C4   . D12 C  2 .   ? 131.610 139.199 115.242 1.00 20.00  ? 401 D12 U C4   1 
HETATM 4221 C C5   . D12 C  2 .   ? 131.427 140.282 114.179 1.00 20.00  ? 401 D12 U C5   1 
HETATM 4222 C C6   . D12 C  2 .   ? 131.563 139.731 112.759 1.00 20.00  ? 401 D12 U C6   1 
HETATM 4223 C C7   . D12 C  2 .   ? 130.275 139.823 111.944 1.00 20.00  ? 401 D12 U C7   1 
HETATM 4224 C C8   . D12 C  2 .   ? 130.221 141.067 111.061 1.00 20.00  ? 401 D12 U C8   1 
HETATM 4225 C C9   . D12 C  2 .   ? 130.508 140.742 109.596 1.00 20.00  ? 401 D12 U C9   1 
HETATM 4226 C C10  . D12 C  2 .   ? 130.901 141.976 108.786 1.00 20.00  ? 401 D12 U C10  1 
HETATM 4227 C C11  . D12 C  2 .   ? 131.438 141.612 107.403 1.00 20.00  ? 401 D12 U C11  1 
HETATM 4228 C C12  . D12 C  2 .   ? 131.290 142.752 106.397 1.00 20.00  ? 401 D12 U C12  1 
HETATM 4229 H H11  . D12 C  2 .   ? 130.605 141.095 119.389 1.00 20.00  ? 401 D12 U H11  1 
HETATM 4230 H H12  . D12 C  2 .   ? 131.769 142.019 118.421 1.00 20.00  ? 401 D12 U H12  1 
HETATM 4231 H H13  . D12 C  2 .   ? 132.233 140.451 119.106 1.00 20.00  ? 401 D12 U H13  1 
HETATM 4232 H H21  . D12 C  2 .   ? 130.380 141.040 116.801 1.00 20.00  ? 401 D12 U H21  1 
HETATM 4233 H H22  . D12 C  2 .   ? 130.251 139.520 117.692 1.00 20.00  ? 401 D12 U H22  1 
HETATM 4234 H H31  . D12 C  2 .   ? 132.533 138.942 117.153 1.00 20.00  ? 401 D12 U H31  1 
HETATM 4235 H H32  . D12 C  2 .   ? 132.808 140.524 116.422 1.00 20.00  ? 401 D12 U H32  1 
HETATM 4236 H H41  . D12 C  2 .   ? 130.665 138.684 115.379 1.00 20.00  ? 401 D12 U H41  1 
HETATM 4237 H H42  . D12 C  2 .   ? 132.349 138.484 114.895 1.00 20.00  ? 401 D12 U H42  1 
HETATM 4238 H H51  . D12 C  2 .   ? 130.448 140.732 114.300 1.00 20.00  ? 401 D12 U H51  1 
HETATM 4239 H H52  . D12 C  2 .   ? 132.181 141.048 114.326 1.00 20.00  ? 401 D12 U H52  1 
HETATM 4240 H H61  . D12 C  2 .   ? 132.343 140.283 112.245 1.00 20.00  ? 401 D12 U H61  1 
HETATM 4241 H H62  . D12 C  2 .   ? 131.859 138.689 112.810 1.00 20.00  ? 401 D12 U H62  1 
HETATM 4242 H H71  . D12 C  2 .   ? 130.203 138.946 111.310 1.00 20.00  ? 401 D12 U H71  1 
HETATM 4243 H H72  . D12 C  2 .   ? 129.424 139.832 112.616 1.00 20.00  ? 401 D12 U H72  1 
HETATM 4244 H H81  . D12 C  2 .   ? 130.953 141.787 111.413 1.00 20.00  ? 401 D12 U H81  1 
HETATM 4245 H H82  . D12 C  2 .   ? 129.232 141.507 111.134 1.00 20.00  ? 401 D12 U H82  1 
HETATM 4246 H H91  . D12 C  2 .   ? 129.619 140.302 109.156 1.00 20.00  ? 401 D12 U H91  1 
HETATM 4247 H H92  . D12 C  2 .   ? 131.317 140.020 109.550 1.00 20.00  ? 401 D12 U H92  1 
HETATM 4248 H H101 . D12 C  2 .   ? 130.029 142.611 108.669 1.00 20.00  ? 401 D12 U H101 1 
HETATM 4249 H H102 . D12 C  2 .   ? 131.665 142.524 109.327 1.00 20.00  ? 401 D12 U H102 1 
HETATM 4250 H H111 . D12 C  2 .   ? 130.898 140.747 107.034 1.00 20.00  ? 401 D12 U H111 1 
HETATM 4251 H H112 . D12 C  2 .   ? 132.489 141.359 107.492 1.00 20.00  ? 401 D12 U H112 1 
HETATM 4252 H H121 . D12 C  2 .   ? 131.725 142.455 105.448 1.00 20.00  ? 401 D12 U H121 1 
HETATM 4253 H H122 . D12 C  2 .   ? 130.237 142.978 106.258 1.00 20.00  ? 401 D12 U H122 1 
HETATM 4254 H H123 . D12 C  2 .   ? 131.802 143.634 106.771 1.00 20.00  ? 401 D12 U H123 1 
HETATM 4255 C C1   . D12 D  2 .   ? 111.917 96.851  134.661 1.00 20.00  ? 402 D12 U C1   1 
HETATM 4256 C C2   . D12 D  2 .   ? 112.895 97.341  133.597 1.00 20.00  ? 402 D12 U C2   1 
HETATM 4257 C C3   . D12 D  2 .   ? 112.312 97.252  132.191 1.00 20.00  ? 402 D12 U C3   1 
HETATM 4258 C C4   . D12 D  2 .   ? 111.782 98.593  131.692 1.00 20.00  ? 402 D12 U C4   1 
HETATM 4259 C C5   . D12 D  2 .   ? 112.900 99.564  131.320 1.00 20.00  ? 402 D12 U C5   1 
HETATM 4260 C C6   . D12 D  2 .   ? 113.247 99.527  129.831 1.00 20.00  ? 402 D12 U C6   1 
HETATM 4261 C C7   . D12 D  2 .   ? 112.745 100.750 129.069 1.00 20.00  ? 402 D12 U C7   1 
HETATM 4262 C C8   . D12 D  2 .   ? 113.592 101.044 127.835 1.00 20.00  ? 402 D12 U C8   1 
HETATM 4263 C C9   . D12 D  2 .   ? 113.757 99.819  126.943 1.00 20.00  ? 402 D12 U C9   1 
HETATM 4264 C C10  . D12 D  2 .   ? 114.233 100.187 125.542 1.00 20.00  ? 402 D12 U C10  1 
HETATM 4265 C C11  . D12 D  2 .   ? 115.593 100.882 125.547 1.00 20.00  ? 402 D12 U C11  1 
HETATM 4266 C C12  . D12 D  2 .   ? 115.485 102.393 125.360 1.00 20.00  ? 402 D12 U C12  1 
HETATM 4267 H H11  . D12 D  2 .   ? 110.944 97.300  134.493 1.00 20.00  ? 402 D12 U H11  1 
HETATM 4268 H H12  . D12 D  2 .   ? 112.281 97.131  135.645 1.00 20.00  ? 402 D12 U H12  1 
HETATM 4269 H H13  . D12 D  2 .   ? 111.831 95.769  134.601 1.00 20.00  ? 402 D12 U H13  1 
HETATM 4270 H H21  . D12 D  2 .   ? 113.796 96.737  133.644 1.00 20.00  ? 402 D12 U H21  1 
HETATM 4271 H H22  . D12 D  2 .   ? 113.153 98.373  133.811 1.00 20.00  ? 402 D12 U H22  1 
HETATM 4272 H H31  . D12 D  2 .   ? 111.500 96.533  132.192 1.00 20.00  ? 402 D12 U H31  1 
HETATM 4273 H H32  . D12 D  2 .   ? 113.085 96.907  131.512 1.00 20.00  ? 402 D12 U H32  1 
HETATM 4274 H H41  . D12 D  2 .   ? 111.180 99.041  132.476 1.00 20.00  ? 402 D12 U H41  1 
HETATM 4275 H H42  . D12 D  2 .   ? 111.153 98.423  130.825 1.00 20.00  ? 402 D12 U H42  1 
HETATM 4276 H H51  . D12 D  2 .   ? 112.590 100.568 131.591 1.00 20.00  ? 402 D12 U H51  1 
HETATM 4277 H H52  . D12 D  2 .   ? 113.789 99.311  131.886 1.00 20.00  ? 402 D12 U H52  1 
HETATM 4278 H H61  . D12 D  2 .   ? 114.326 99.475  129.730 1.00 20.00  ? 402 D12 U H61  1 
HETATM 4279 H H62  . D12 D  2 .   ? 112.814 98.636  129.389 1.00 20.00  ? 402 D12 U H62  1 
HETATM 4280 H H71  . D12 D  2 .   ? 111.720 100.576 128.758 1.00 20.00  ? 402 D12 U H71  1 
HETATM 4281 H H72  . D12 D  2 .   ? 112.773 101.618 129.720 1.00 20.00  ? 402 D12 U H72  1 
HETATM 4282 H H81  . D12 D  2 .   ? 114.573 101.382 128.154 1.00 20.00  ? 402 D12 U H81  1 
HETATM 4283 H H82  . D12 D  2 .   ? 113.116 101.834 127.263 1.00 20.00  ? 402 D12 U H82  1 
HETATM 4284 H H91  . D12 D  2 .   ? 112.803 99.307  126.869 1.00 20.00  ? 402 D12 U H91  1 
HETATM 4285 H H92  . D12 D  2 .   ? 114.481 99.149  127.395 1.00 20.00  ? 402 D12 U H92  1 
HETATM 4286 H H101 . D12 D  2 .   ? 114.303 99.284  124.946 1.00 20.00  ? 402 D12 U H101 1 
HETATM 4287 H H102 . D12 D  2 .   ? 113.503 100.850 125.087 1.00 20.00  ? 402 D12 U H102 1 
HETATM 4288 H H111 . D12 D  2 .   ? 116.197 100.473 124.744 1.00 20.00  ? 402 D12 U H111 1 
HETATM 4289 H H112 . D12 D  2 .   ? 116.086 100.680 126.493 1.00 20.00  ? 402 D12 U H112 1 
HETATM 4290 H H121 . D12 D  2 .   ? 114.969 102.606 124.430 1.00 20.00  ? 402 D12 U H121 1 
HETATM 4291 H H122 . D12 D  2 .   ? 114.931 102.824 126.189 1.00 20.00  ? 402 D12 U H122 1 
HETATM 4292 H H123 . D12 D  2 .   ? 116.480 102.824 125.329 1.00 20.00  ? 402 D12 U H123 1 
HETATM 4293 C C1   . OCT E  3 .   ? 143.610 118.485 114.983 1.00 20.00  ? 403 OCT U C1   1 
HETATM 4294 C C2   . OCT E  3 .   ? 144.105 117.919 113.656 1.00 20.00  ? 403 OCT U C2   1 
HETATM 4295 C C3   . OCT E  3 .   ? 143.803 118.844 112.481 1.00 20.00  ? 403 OCT U C3   1 
HETATM 4296 C C4   . OCT E  3 .   ? 144.022 118.163 111.133 1.00 20.00  ? 403 OCT U C4   1 
HETATM 4297 C C5   . OCT E  3 .   ? 145.113 118.841 110.308 1.00 20.00  ? 403 OCT U C5   1 
HETATM 4298 C C6   . OCT E  3 .   ? 145.066 118.429 108.839 1.00 20.00  ? 403 OCT U C6   1 
HETATM 4299 C C7   . OCT E  3 .   ? 146.122 119.148 108.006 1.00 20.00  ? 403 OCT U C7   1 
HETATM 4300 C C8   . OCT E  3 .   ? 146.211 118.598 106.585 1.00 20.00  ? 403 OCT U C8   1 
HETATM 4301 H H11  . OCT E  3 .   ? 143.870 117.805 115.785 1.00 20.00  ? 403 OCT U H11  1 
HETATM 4302 H H12  . OCT E  3 .   ? 144.075 119.446 115.161 1.00 20.00  ? 403 OCT U H12  1 
HETATM 4303 H H13  . OCT E  3 .   ? 142.534 118.606 114.946 1.00 20.00  ? 403 OCT U H13  1 
HETATM 4304 H H21  . OCT E  3 .   ? 143.624 116.964 113.482 1.00 20.00  ? 403 OCT U H21  1 
HETATM 4305 H H22  . OCT E  3 .   ? 145.176 117.766 113.716 1.00 20.00  ? 403 OCT U H22  1 
HETATM 4306 H H31  . OCT E  3 .   ? 142.772 119.168 112.545 1.00 20.00  ? 403 OCT U H31  1 
HETATM 4307 H H32  . OCT E  3 .   ? 144.448 119.712 112.547 1.00 20.00  ? 403 OCT U H32  1 
HETATM 4308 H H41  . OCT E  3 .   ? 144.304 117.131 111.301 1.00 20.00  ? 403 OCT U H41  1 
HETATM 4309 H H42  . OCT E  3 .   ? 143.095 118.186 110.573 1.00 20.00  ? 403 OCT U H42  1 
HETATM 4310 H H51  . OCT E  3 .   ? 146.080 118.575 110.716 1.00 20.00  ? 403 OCT U H51  1 
HETATM 4311 H H52  . OCT E  3 .   ? 144.988 119.915 110.372 1.00 20.00  ? 403 OCT U H52  1 
HETATM 4312 H H61  . OCT E  3 .   ? 145.229 117.361 108.769 1.00 20.00  ? 403 OCT U H61  1 
HETATM 4313 H H62  . OCT E  3 .   ? 144.086 118.662 108.441 1.00 20.00  ? 403 OCT U H62  1 
HETATM 4314 H H71  . OCT E  3 .   ? 145.876 120.201 107.960 1.00 20.00  ? 403 OCT U H71  1 
HETATM 4315 H H72  . OCT E  3 .   ? 147.086 119.034 108.487 1.00 20.00  ? 403 OCT U H72  1 
HETATM 4316 H H81  . OCT E  3 .   ? 146.905 119.197 106.009 1.00 20.00  ? 403 OCT U H81  1 
HETATM 4317 H H82  . OCT E  3 .   ? 146.559 117.573 106.615 1.00 20.00  ? 403 OCT U H82  1 
HETATM 4318 H H83  . OCT E  3 .   ? 145.233 118.635 106.122 1.00 20.00  ? 403 OCT U H83  1 
HETATM 4319 C C1   . OCT F  3 .   ? 113.652 146.128 113.610 1.00 20.00  ? 404 OCT U C1   1 
HETATM 4320 C C2   . OCT F  3 .   ? 113.854 146.161 112.097 1.00 20.00  ? 404 OCT U C2   1 
HETATM 4321 C C3   . OCT F  3 .   ? 113.015 147.247 111.427 1.00 20.00  ? 404 OCT U C3   1 
HETATM 4322 C C4   . OCT F  3 .   ? 112.669 146.907 109.980 1.00 20.00  ? 404 OCT U C4   1 
HETATM 4323 C C5   . OCT F  3 .   ? 113.889 146.964 109.066 1.00 20.00  ? 404 OCT U C5   1 
HETATM 4324 C C6   . OCT F  3 .   ? 113.512 146.908 107.588 1.00 20.00  ? 404 OCT U C6   1 
HETATM 4325 C C7   . OCT F  3 .   ? 113.064 148.261 107.047 1.00 20.00  ? 404 OCT U C7   1 
HETATM 4326 C C8   . OCT F  3 .   ? 112.945 148.261 105.526 1.00 20.00  ? 404 OCT U C8   1 
HETATM 4327 H H11  . OCT F  3 .   ? 114.340 145.416 114.049 1.00 20.00  ? 404 OCT U H11  1 
HETATM 4328 H H12  . OCT F  3 .   ? 113.838 147.112 114.021 1.00 20.00  ? 404 OCT U H12  1 
HETATM 4329 H H13  . OCT F  3 .   ? 112.635 145.830 113.832 1.00 20.00  ? 404 OCT U H13  1 
HETATM 4330 H H21  . OCT F  3 .   ? 113.578 145.199 111.685 1.00 20.00  ? 404 OCT U H21  1 
HETATM 4331 H H22  . OCT F  3 .   ? 114.900 146.346 111.887 1.00 20.00  ? 404 OCT U H22  1 
HETATM 4332 H H31  . OCT F  3 .   ? 112.097 147.374 111.986 1.00 20.00  ? 404 OCT U H31  1 
HETATM 4333 H H32  . OCT F  3 .   ? 113.568 148.178 111.446 1.00 20.00  ? 404 OCT U H32  1 
HETATM 4334 H H41  . OCT F  3 .   ? 112.249 145.909 109.943 1.00 20.00  ? 404 OCT U H41  1 
HETATM 4335 H H42  . OCT F  3 .   ? 111.929 147.612 109.622 1.00 20.00  ? 404 OCT U H42  1 
HETATM 4336 H H51  . OCT F  3 .   ? 114.537 146.126 109.294 1.00 20.00  ? 404 OCT U H51  1 
HETATM 4337 H H52  . OCT F  3 .   ? 114.427 147.884 109.256 1.00 20.00  ? 404 OCT U H52  1 
HETATM 4338 H H61  . OCT F  3 .   ? 114.371 146.571 107.021 1.00 20.00  ? 404 OCT U H61  1 
HETATM 4339 H H62  . OCT F  3 .   ? 112.706 146.195 107.459 1.00 20.00  ? 404 OCT U H62  1 
HETATM 4340 H H71  . OCT F  3 .   ? 112.098 148.509 107.474 1.00 20.00  ? 404 OCT U H71  1 
HETATM 4341 H H72  . OCT F  3 .   ? 113.783 149.015 107.343 1.00 20.00  ? 404 OCT U H72  1 
HETATM 4342 H H81  . OCT F  3 .   ? 112.578 149.224 105.192 1.00 20.00  ? 404 OCT U H81  1 
HETATM 4343 H H82  . OCT F  3 .   ? 113.918 148.074 105.087 1.00 20.00  ? 404 OCT U H82  1 
HETATM 4344 H H83  . OCT F  3 .   ? 112.254 147.485 105.217 1.00 20.00  ? 404 OCT U H83  1 
HETATM 4345 C C1   . D12 G  2 .   ? 119.430 144.647 116.260 1.00 20.00  ? 405 D12 U C1   1 
HETATM 4346 C C2   . D12 G  2 .   ? 120.199 145.322 115.128 1.00 20.00  ? 405 D12 U C2   1 
HETATM 4347 C C3   . D12 G  2 .   ? 119.478 146.555 114.591 1.00 20.00  ? 405 D12 U C3   1 
HETATM 4348 C C4   . D12 G  2 .   ? 119.962 146.955 113.198 1.00 20.00  ? 405 D12 U C4   1 
HETATM 4349 C C5   . D12 G  2 .   ? 119.115 146.370 112.069 1.00 20.00  ? 405 D12 U C5   1 
HETATM 4350 C C6   . D12 G  2 .   ? 119.238 147.190 110.787 1.00 20.00  ? 405 D12 U C6   1 
HETATM 4351 C C7   . D12 G  2 .   ? 119.292 146.328 109.528 1.00 20.00  ? 405 D12 U C7   1 
HETATM 4352 C C8   . D12 G  2 .   ? 119.748 147.129 108.309 1.00 20.00  ? 405 D12 U C8   1 
HETATM 4353 C C9   . D12 G  2 .   ? 118.830 146.980 107.098 1.00 20.00  ? 405 D12 U C9   1 
HETATM 4354 C C10  . D12 G  2 .   ? 118.894 148.203 106.185 1.00 20.00  ? 405 D12 U C10  1 
HETATM 4355 C C11  . D12 G  2 .   ? 118.591 147.863 104.729 1.00 20.00  ? 405 D12 U C11  1 
HETATM 4356 C C12  . D12 G  2 .   ? 118.347 149.110 103.882 1.00 20.00  ? 405 D12 U C12  1 
HETATM 4357 H H11  . D12 G  2 .   ? 118.951 145.404 116.875 1.00 20.00  ? 405 D12 U H11  1 
HETATM 4358 H H12  . D12 G  2 .   ? 120.118 144.069 116.870 1.00 20.00  ? 405 D12 U H12  1 
HETATM 4359 H H13  . D12 G  2 .   ? 118.674 143.988 115.843 1.00 20.00  ? 405 D12 U H13  1 
HETATM 4360 H H21  . D12 G  2 .   ? 120.331 144.611 114.319 1.00 20.00  ? 405 D12 U H21  1 
HETATM 4361 H H22  . D12 G  2 .   ? 121.175 145.620 115.495 1.00 20.00  ? 405 D12 U H22  1 
HETATM 4362 H H31  . D12 G  2 .   ? 119.648 147.383 115.270 1.00 20.00  ? 405 D12 U H31  1 
HETATM 4363 H H32  . D12 G  2 .   ? 118.413 146.348 114.552 1.00 20.00  ? 405 D12 U H32  1 
HETATM 4364 H H41  . D12 G  2 .   ? 120.985 146.614 113.076 1.00 20.00  ? 405 D12 U H41  1 
HETATM 4365 H H42  . D12 G  2 .   ? 119.943 148.037 113.122 1.00 20.00  ? 405 D12 U H42  1 
HETATM 4366 H H51  . D12 G  2 .   ? 119.439 145.352 111.874 1.00 20.00  ? 405 D12 U H51  1 
HETATM 4367 H H52  . D12 G  2 .   ? 118.073 146.356 112.374 1.00 20.00  ? 405 D12 U H52  1 
HETATM 4368 H H61  . D12 G  2 .   ? 118.387 147.859 110.716 1.00 20.00  ? 405 D12 U H61  1 
HETATM 4369 H H62  . D12 G  2 .   ? 120.145 147.783 110.839 1.00 20.00  ? 405 D12 U H62  1 
HETATM 4370 H H71  . D12 G  2 .   ? 119.988 145.511 109.688 1.00 20.00  ? 405 D12 U H71  1 
HETATM 4371 H H72  . D12 G  2 .   ? 118.306 145.917 109.340 1.00 20.00  ? 405 D12 U H72  1 
HETATM 4372 H H81  . D12 G  2 .   ? 120.744 146.799 108.032 1.00 20.00  ? 405 D12 U H81  1 
HETATM 4373 H H82  . D12 G  2 .   ? 119.794 148.178 108.581 1.00 20.00  ? 405 D12 U H82  1 
HETATM 4374 H H91  . D12 G  2 .   ? 117.808 146.852 107.436 1.00 20.00  ? 405 D12 U H91  1 
HETATM 4375 H H92  . D12 G  2 .   ? 119.129 146.103 106.534 1.00 20.00  ? 405 D12 U H92  1 
HETATM 4376 H H101 . D12 G  2 .   ? 118.172 148.935 106.531 1.00 20.00  ? 405 D12 U H101 1 
HETATM 4377 H H102 . D12 G  2 .   ? 119.888 148.633 106.245 1.00 20.00  ? 405 D12 U H102 1 
HETATM 4378 H H111 . D12 G  2 .   ? 117.707 147.234 104.691 1.00 20.00  ? 405 D12 U H111 1 
HETATM 4379 H H112 . D12 G  2 .   ? 119.430 147.315 104.314 1.00 20.00  ? 405 D12 U H112 1 
HETATM 4380 H H121 . D12 G  2 .   ? 118.166 148.818 102.851 1.00 20.00  ? 405 D12 U H121 1 
HETATM 4381 H H122 . D12 G  2 .   ? 117.480 149.642 104.264 1.00 20.00  ? 405 D12 U H122 1 
HETATM 4382 H H123 . D12 G  2 .   ? 119.218 149.756 103.929 1.00 20.00  ? 405 D12 U H123 1 
HETATM 4383 C C1   . HEX H  4 .   ? 136.454 141.721 113.718 1.00 20.00  ? 406 HEX U C1   1 
HETATM 4384 C C2   . HEX H  4 .   ? 137.199 141.429 112.418 1.00 20.00  ? 406 HEX U C2   1 
HETATM 4385 C C3   . HEX H  4 .   ? 136.252 141.094 111.267 1.00 20.00  ? 406 HEX U C3   1 
HETATM 4386 C C4   . HEX H  4 .   ? 136.805 141.529 109.913 1.00 20.00  ? 406 HEX U C4   1 
HETATM 4387 C C5   . HEX H  4 .   ? 135.779 141.373 108.795 1.00 20.00  ? 406 HEX U C5   1 
HETATM 4388 C C6   . HEX H  4 .   ? 136.430 141.212 107.424 1.00 20.00  ? 406 HEX U C6   1 
HETATM 4389 H H11  . HEX H  4 .   ? 135.946 140.824 114.052 1.00 20.00  ? 406 HEX U H11  1 
HETATM 4390 H H12  . HEX H  4 .   ? 135.728 142.506 113.551 1.00 20.00  ? 406 HEX U H12  1 
HETATM 4391 H H13  . HEX H  4 .   ? 137.161 142.038 114.475 1.00 20.00  ? 406 HEX U H13  1 
HETATM 4392 H H21  . HEX H  4 .   ? 137.866 140.589 112.576 1.00 20.00  ? 406 HEX U H21  1 
HETATM 4393 H H22  . HEX H  4 .   ? 137.785 142.297 112.148 1.00 20.00  ? 406 HEX U H22  1 
HETATM 4394 H H31  . HEX H  4 .   ? 135.306 141.594 111.436 1.00 20.00  ? 406 HEX U H31  1 
HETATM 4395 H H32  . HEX H  4 .   ? 136.085 140.025 111.250 1.00 20.00  ? 406 HEX U H32  1 
HETATM 4396 H H41  . HEX H  4 .   ? 137.104 142.569 109.971 1.00 20.00  ? 406 HEX U H41  1 
HETATM 4397 H H42  . HEX H  4 .   ? 137.674 140.926 109.678 1.00 20.00  ? 406 HEX U H42  1 
HETATM 4398 H H51  . HEX H  4 .   ? 135.170 140.500 108.999 1.00 20.00  ? 406 HEX U H51  1 
HETATM 4399 H H52  . HEX H  4 .   ? 135.141 142.249 108.779 1.00 20.00  ? 406 HEX U H52  1 
HETATM 4400 H H61  . HEX H  4 .   ? 135.683 141.349 106.651 1.00 20.00  ? 406 HEX U H61  1 
HETATM 4401 H H62  . HEX H  4 .   ? 136.856 140.220 107.342 1.00 20.00  ? 406 HEX U H62  1 
HETATM 4402 H H63  . HEX H  4 .   ? 137.212 141.952 107.307 1.00 20.00  ? 406 HEX U H63  1 
HETATM 4403 C C1   . OCT I  3 .   ? 129.698 146.370 116.973 1.00 20.00  ? 407 OCT U C1   1 
HETATM 4404 C C2   . OCT I  3 .   ? 129.779 146.070 115.478 1.00 20.00  ? 407 OCT U C2   1 
HETATM 4405 C C3   . OCT I  3 .   ? 129.207 147.207 114.635 1.00 20.00  ? 407 OCT U C3   1 
HETATM 4406 C C4   . OCT I  3 .   ? 128.595 146.731 113.318 1.00 20.00  ? 407 OCT U C4   1 
HETATM 4407 C C5   . OCT I  3 .   ? 129.601 146.718 112.170 1.00 20.00  ? 407 OCT U C5   1 
HETATM 4408 C C6   . OCT I  3 .   ? 129.378 147.878 111.204 1.00 20.00  ? 407 OCT U C6   1 
HETATM 4409 C C7   . OCT I  3 .   ? 130.225 147.759 109.941 1.00 20.00  ? 407 OCT U C7   1 
HETATM 4410 C C8   . OCT I  3 .   ? 130.020 148.941 108.998 1.00 20.00  ? 407 OCT U C8   1 
HETATM 4411 H H11  . OCT I  3 .   ? 130.148 145.557 117.529 1.00 20.00  ? 407 OCT U H11  1 
HETATM 4412 H H12  . OCT I  3 .   ? 130.229 147.290 117.185 1.00 20.00  ? 407 OCT U H12  1 
HETATM 4413 H H13  . OCT I  3 .   ? 128.661 146.476 117.265 1.00 20.00  ? 407 OCT U H13  1 
HETATM 4414 H H21  . OCT I  3 .   ? 129.226 145.161 115.277 1.00 20.00  ? 407 OCT U H21  1 
HETATM 4415 H H22  . OCT I  3 .   ? 130.816 145.918 115.207 1.00 20.00  ? 407 OCT U H22  1 
HETATM 4416 H H31  . OCT I  3 .   ? 128.442 147.713 115.209 1.00 20.00  ? 407 OCT U H31  1 
HETATM 4417 H H32  . OCT I  3 .   ? 130.000 147.913 114.417 1.00 20.00  ? 407 OCT U H32  1 
HETATM 4418 H H41  . OCT I  3 .   ? 128.201 145.732 113.447 1.00 20.00  ? 407 OCT U H41  1 
HETATM 4419 H H42  . OCT I  3 .   ? 127.780 147.395 113.059 1.00 20.00  ? 407 OCT U H42  1 
HETATM 4420 H H51  . OCT I  3 .   ? 129.499 145.787 111.627 1.00 20.00  ? 407 OCT U H51  1 
HETATM 4421 H H52  . OCT I  3 .   ? 130.604 146.782 112.573 1.00 20.00  ? 407 OCT U H52  1 
HETATM 4422 H H61  . OCT I  3 .   ? 128.332 147.903 110.920 1.00 20.00  ? 407 OCT U H61  1 
HETATM 4423 H H62  . OCT I  3 .   ? 129.626 148.806 111.707 1.00 20.00  ? 407 OCT U H62  1 
HETATM 4424 H H71  . OCT I  3 .   ? 131.269 147.710 110.223 1.00 20.00  ? 407 OCT U H71  1 
HETATM 4425 H H72  . OCT I  3 .   ? 129.957 146.846 109.424 1.00 20.00  ? 407 OCT U H72  1 
HETATM 4426 H H81  . OCT I  3 .   ? 130.232 149.864 109.524 1.00 20.00  ? 407 OCT U H81  1 
HETATM 4427 H H82  . OCT I  3 .   ? 130.687 148.846 108.151 1.00 20.00  ? 407 OCT U H82  1 
HETATM 4428 H H83  . OCT I  3 .   ? 128.994 148.952 108.650 1.00 20.00  ? 407 OCT U H83  1 
HETATM 4429 C C1   . HEX J  4 .   ? 94.461  116.293 112.794 1.00 20.00  ? 408 HEX U C1   1 
HETATM 4430 C C2   . HEX J  4 .   ? 94.544  116.878 111.385 1.00 20.00  ? 408 HEX U C2   1 
HETATM 4431 C C3   . HEX J  4 .   ? 93.747  116.063 110.370 1.00 20.00  ? 408 HEX U C3   1 
HETATM 4432 C C4   . HEX J  4 .   ? 94.327  116.163 108.962 1.00 20.00  ? 408 HEX U C4   1 
HETATM 4433 C C5   . HEX J  4 .   ? 93.248  116.041 107.889 1.00 20.00  ? 408 HEX U C5   1 
HETATM 4434 C C6   . HEX J  4 .   ? 93.832  115.941 106.482 1.00 20.00  ? 408 HEX U C6   1 
HETATM 4435 H H11  . HEX J  4 .   ? 94.943  115.324 112.812 1.00 20.00  ? 408 HEX U H11  1 
HETATM 4436 H H12  . HEX J  4 .   ? 93.422  116.185 113.079 1.00 20.00  ? 408 HEX U H12  1 
HETATM 4437 H H13  . HEX J  4 .   ? 94.959  116.958 113.490 1.00 20.00  ? 408 HEX U H13  1 
HETATM 4438 H H21  . HEX J  4 .   ? 95.582  116.901 111.077 1.00 20.00  ? 408 HEX U H21  1 
HETATM 4439 H H22  . HEX J  4 .   ? 94.160  117.889 111.402 1.00 20.00  ? 408 HEX U H22  1 
HETATM 4440 H H31  . HEX J  4 .   ? 92.725  116.422 110.356 1.00 20.00  ? 408 HEX U H31  1 
HETATM 4441 H H32  . HEX J  4 .   ? 93.748  115.024 110.676 1.00 20.00  ? 408 HEX U H32  1 
HETATM 4442 H H41  . HEX J  4 .   ? 94.823  117.119 108.854 1.00 20.00  ? 408 HEX U H41  1 
HETATM 4443 H H42  . HEX J  4 .   ? 95.053  115.372 108.822 1.00 20.00  ? 408 HEX U H42  1 
HETATM 4444 H H51  . HEX J  4 .   ? 92.658  115.155 108.086 1.00 20.00  ? 408 HEX U H51  1 
HETATM 4445 H H52  . HEX J  4 .   ? 92.604  116.910 107.939 1.00 20.00  ? 408 HEX U H52  1 
HETATM 4446 H H61  . HEX J  4 .   ? 93.045  116.092 105.754 1.00 20.00  ? 408 HEX U H61  1 
HETATM 4447 H H62  . HEX J  4 .   ? 94.271  114.962 106.342 1.00 20.00  ? 408 HEX U H62  1 
HETATM 4448 H H63  . HEX J  4 .   ? 94.594  116.700 106.353 1.00 20.00  ? 408 HEX U H63  1 
HETATM 4449 C C1   . HEX K  4 .   ? 100.065 130.328 113.085 1.00 20.00  ? 409 HEX U C1   1 
HETATM 4450 C C2   . HEX K  4 .   ? 99.860  131.437 112.056 1.00 20.00  ? 409 HEX U C2   1 
HETATM 4451 C C3   . HEX K  4 .   ? 98.770  131.098 111.041 1.00 20.00  ? 409 HEX U C3   1 
HETATM 4452 C C4   . HEX K  4 .   ? 99.199  131.407 109.607 1.00 20.00  ? 409 HEX U C4   1 
HETATM 4453 C C5   . HEX K  4 .   ? 98.008  131.577 108.668 1.00 20.00  ? 409 HEX U C5   1 
HETATM 4454 C C6   . HEX K  4 .   ? 98.420  131.516 107.199 1.00 20.00  ? 409 HEX U C6   1 
HETATM 4455 H H11  . HEX K  4 .   ? 100.440 129.441 112.590 1.00 20.00  ? 409 HEX U H11  1 
HETATM 4456 H H12  . HEX K  4 .   ? 99.120  130.102 113.564 1.00 20.00  ? 409 HEX U H12  1 
HETATM 4457 H H13  . HEX K  4 .   ? 100.779 130.656 113.830 1.00 20.00  ? 409 HEX U H13  1 
HETATM 4458 H H21  . HEX K  4 .   ? 100.791 131.601 111.529 1.00 20.00  ? 409 HEX U H21  1 
HETATM 4459 H H22  . HEX K  4 .   ? 99.585  132.347 112.573 1.00 20.00  ? 409 HEX U H22  1 
HETATM 4460 H H31  . HEX K  4 .   ? 97.883  131.673 111.273 1.00 20.00  ? 409 HEX U H31  1 
HETATM 4461 H H32  . HEX K  4 .   ? 98.536  130.044 111.117 1.00 20.00  ? 409 HEX U H32  1 
HETATM 4462 H H41  . HEX K  4 .   ? 99.780  132.322 109.605 1.00 20.00  ? 409 HEX U H41  1 
HETATM 4463 H H42  . HEX K  4 .   ? 99.819  130.597 109.245 1.00 20.00  ? 409 HEX U H42  1 
HETATM 4464 H H51  . HEX K  4 .   ? 97.292  130.791 108.864 1.00 20.00  ? 409 HEX U H51  1 
HETATM 4465 H H52  . HEX K  4 .   ? 97.542  132.535 108.862 1.00 20.00  ? 409 HEX U H52  1 
HETATM 4466 H H61  . HEX K  4 .   ? 97.609  131.883 106.581 1.00 20.00  ? 409 HEX U H61  1 
HETATM 4467 H H62  . HEX K  4 .   ? 98.643  130.491 106.929 1.00 20.00  ? 409 HEX U H62  1 
HETATM 4468 H H63  . HEX K  4 .   ? 99.298  132.130 107.043 1.00 20.00  ? 409 HEX U H63  1 
HETATM 4469 C C1   . HEX L  4 .   ? 96.149  111.761 115.076 1.00 20.00  ? 410 HEX U C1   1 
HETATM 4470 C C2   . HEX L  4 .   ? 95.973  110.457 114.299 1.00 20.00  ? 410 HEX U C2   1 
HETATM 4471 C C3   . HEX L  4 .   ? 96.011  110.679 112.788 1.00 20.00  ? 410 HEX U C3   1 
HETATM 4472 C C4   . HEX L  4 .   ? 95.118  109.700 112.027 1.00 20.00  ? 410 HEX U C4   1 
HETATM 4473 C C5   . HEX L  4 .   ? 94.767  110.179 110.619 1.00 20.00  ? 410 HEX U C5   1 
HETATM 4474 C C6   . HEX L  4 .   ? 95.750  109.667 109.569 1.00 20.00  ? 410 HEX U C6   1 
HETATM 4475 H H11  . HEX L  4 .   ? 95.363  112.452 114.802 1.00 20.00  ? 410 HEX U H11  1 
HETATM 4476 H H12  . HEX L  4 .   ? 97.111  112.196 114.835 1.00 20.00  ? 410 HEX U H12  1 
HETATM 4477 H H13  . HEX L  4 .   ? 96.101  111.559 116.139 1.00 20.00  ? 410 HEX U H13  1 
HETATM 4478 H H21  . HEX L  4 .   ? 95.023  110.016 114.571 1.00 20.00  ? 410 HEX U H21  1 
HETATM 4479 H H22  . HEX L  4 .   ? 96.768  109.776 114.574 1.00 20.00  ? 410 HEX U H22  1 
HETATM 4480 H H31  . HEX L  4 .   ? 95.694  111.691 112.575 1.00 20.00  ? 410 HEX U H31  1 
HETATM 4481 H H32  . HEX L  4 .   ? 97.031  110.555 112.445 1.00 20.00  ? 410 HEX U H32  1 
HETATM 4482 H H41  . HEX L  4 .   ? 95.633  108.751 111.950 1.00 20.00  ? 410 HEX U H41  1 
HETATM 4483 H H42  . HEX L  4 .   ? 94.202  109.553 112.582 1.00 20.00  ? 410 HEX U H42  1 
HETATM 4484 H H51  . HEX L  4 .   ? 93.777  109.821 110.367 1.00 20.00  ? 410 HEX U H51  1 
HETATM 4485 H H52  . HEX L  4 .   ? 94.765  111.261 110.599 1.00 20.00  ? 410 HEX U H52  1 
HETATM 4486 H H61  . HEX L  4 .   ? 96.762  109.898 109.878 1.00 20.00  ? 410 HEX U H61  1 
HETATM 4487 H H62  . HEX L  4 .   ? 95.544  110.144 108.619 1.00 20.00  ? 410 HEX U H62  1 
HETATM 4488 H H63  . HEX L  4 .   ? 95.641  108.595 109.466 1.00 20.00  ? 410 HEX U H63  1 
HETATM 4489 C C1   . HEX M  4 .   ? 95.619  104.072 119.356 1.00 20.00  ? 411 HEX U C1   1 
HETATM 4490 C C2   . HEX M  4 .   ? 96.520  103.171 118.516 1.00 20.00  ? 411 HEX U C2   1 
HETATM 4491 C C3   . HEX M  4 .   ? 95.776  102.554 117.332 1.00 20.00  ? 411 HEX U C3   1 
HETATM 4492 C C4   . HEX M  4 .   ? 96.659  102.339 116.103 1.00 20.00  ? 411 HEX U C4   1 
HETATM 4493 C C5   . HEX M  4 .   ? 96.133  103.085 114.880 1.00 20.00  ? 411 HEX U C5   1 
HETATM 4494 C C6   . HEX M  4 .   ? 96.901  102.738 113.606 1.00 20.00  ? 411 HEX U C6   1 
HETATM 4495 H H11  . HEX M  4 .   ? 96.179  104.459 120.198 1.00 20.00  ? 411 HEX U H11  1 
HETATM 4496 H H12  . HEX M  4 .   ? 94.772  103.502 119.717 1.00 20.00  ? 411 HEX U H12  1 
HETATM 4497 H H13  . HEX M  4 .   ? 95.266  104.897 118.749 1.00 20.00  ? 411 HEX U H13  1 
HETATM 4498 H H21  . HEX M  4 .   ? 96.906  102.376 119.142 1.00 20.00  ? 411 HEX U H21  1 
HETATM 4499 H H22  . HEX M  4 .   ? 97.349  103.762 118.149 1.00 20.00  ? 411 HEX U H22  1 
HETATM 4500 H H31  . HEX M  4 .   ? 94.957  103.209 117.060 1.00 20.00  ? 411 HEX U H31  1 
HETATM 4501 H H32  . HEX M  4 .   ? 95.369  101.598 117.638 1.00 20.00  ? 411 HEX U H32  1 
HETATM 4502 H H41  . HEX M  4 .   ? 97.666  102.678 116.316 1.00 20.00  ? 411 HEX U H41  1 
HETATM 4503 H H42  . HEX M  4 .   ? 96.690  101.280 115.877 1.00 20.00  ? 411 HEX U H42  1 
HETATM 4504 H H51  . HEX M  4 .   ? 95.090  102.835 114.737 1.00 20.00  ? 411 HEX U H51  1 
HETATM 4505 H H52  . HEX M  4 .   ? 96.216  104.149 115.061 1.00 20.00  ? 411 HEX U H52  1 
HETATM 4506 H H61  . HEX M  4 .   ? 96.813  103.552 112.897 1.00 20.00  ? 411 HEX U H61  1 
HETATM 4507 H H62  . HEX M  4 .   ? 96.490  101.835 113.172 1.00 20.00  ? 411 HEX U H62  1 
HETATM 4508 H H63  . HEX M  4 .   ? 97.945  102.579 113.846 1.00 20.00  ? 411 HEX U H63  1 
HETATM 4509 C C1   . HEX N  4 .   ? 93.179  110.093 116.899 1.00 20.00  ? 412 HEX U C1   1 
HETATM 4510 C C2   . HEX N  4 .   ? 92.379  109.903 115.614 1.00 20.00  ? 412 HEX U C2   1 
HETATM 4511 C C3   . HEX N  4 .   ? 92.271  111.194 114.805 1.00 20.00  ? 412 HEX U C3   1 
HETATM 4512 C C4   . HEX N  4 .   ? 91.800  110.956 113.371 1.00 20.00  ? 412 HEX U C4   1 
HETATM 4513 C C5   . HEX N  4 .   ? 92.394  111.974 112.400 1.00 20.00  ? 412 HEX U C5   1 
HETATM 4514 C C6   . HEX N  4 .   ? 91.874  111.796 110.975 1.00 20.00  ? 412 HEX U C6   1 
HETATM 4515 H H11  . HEX N  4 .   ? 94.153  110.504 116.661 1.00 20.00  ? 412 HEX U H11  1 
HETATM 4516 H H12  . HEX N  4 .   ? 93.303  109.138 117.394 1.00 20.00  ? 412 HEX U H12  1 
HETATM 4517 H H13  . HEX N  4 .   ? 92.653  110.775 117.556 1.00 20.00  ? 412 HEX U H13  1 
HETATM 4518 H H21  . HEX N  4 .   ? 91.383  109.563 115.867 1.00 20.00  ? 412 HEX U H21  1 
HETATM 4519 H H22  . HEX N  4 .   ? 92.865  109.147 115.009 1.00 20.00  ? 412 HEX U H22  1 
HETATM 4520 H H31  . HEX N  4 .   ? 93.243  111.671 114.777 1.00 20.00  ? 412 HEX U H31  1 
HETATM 4521 H H32  . HEX N  4 .   ? 91.571  111.857 115.296 1.00 20.00  ? 412 HEX U H32  1 
HETATM 4522 H H41  . HEX N  4 .   ? 92.089  109.959 113.062 1.00 20.00  ? 412 HEX U H41  1 
HETATM 4523 H H42  . HEX N  4 .   ? 90.721  111.033 113.341 1.00 20.00  ? 412 HEX U H42  1 
HETATM 4524 H H51  . HEX N  4 .   ? 92.142  112.969 112.742 1.00 20.00  ? 412 HEX U H51  1 
HETATM 4525 H H52  . HEX N  4 .   ? 93.470  111.868 112.397 1.00 20.00  ? 412 HEX U H52  1 
HETATM 4526 H H61  . HEX N  4 .   ? 90.915  112.289 110.877 1.00 20.00  ? 412 HEX U H61  1 
HETATM 4527 H H62  . HEX N  4 .   ? 91.759  110.741 110.761 1.00 20.00  ? 412 HEX U H62  1 
HETATM 4528 H H63  . HEX N  4 .   ? 92.579  112.231 110.278 1.00 20.00  ? 412 HEX U H63  1 
HETATM 4529 C C1   . HEX O  4 .   ? 97.487  106.993 119.429 1.00 20.00  ? 413 HEX U C1   1 
HETATM 4530 C C2   . HEX O  4 .   ? 98.285  107.800 118.411 1.00 20.00  ? 413 HEX U C2   1 
HETATM 4531 C C3   . HEX O  4 .   ? 97.641  107.787 117.029 1.00 20.00  ? 413 HEX U C3   1 
HETATM 4532 C C4   . HEX O  4 .   ? 97.761  106.430 116.341 1.00 20.00  ? 413 HEX U C4   1 
HETATM 4533 C C5   . HEX O  4 .   ? 97.625  106.525 114.822 1.00 20.00  ? 413 HEX U C5   1 
HETATM 4534 C C6   . HEX O  4 .   ? 98.639  105.643 114.101 1.00 20.00  ? 413 HEX U C6   1 
HETATM 4535 H H11  . HEX O  4 .   ? 97.816  107.248 120.429 1.00 20.00  ? 413 HEX U H11  1 
HETATM 4536 H H12  . HEX O  4 .   ? 97.650  105.936 119.255 1.00 20.00  ? 413 HEX U H12  1 
HETATM 4537 H H13  . HEX O  4 .   ? 96.434  107.219 119.325 1.00 20.00  ? 413 HEX U H13  1 
HETATM 4538 H H21  . HEX O  4 .   ? 99.284  107.386 118.337 1.00 20.00  ? 413 HEX U H21  1 
HETATM 4539 H H22  . HEX O  4 .   ? 98.356  108.825 118.755 1.00 20.00  ? 413 HEX U H22  1 
HETATM 4540 H H31  . HEX O  4 .   ? 98.122  108.541 116.418 1.00 20.00  ? 413 HEX U H31  1 
HETATM 4541 H H32  . HEX O  4 .   ? 96.591  108.037 117.130 1.00 20.00  ? 413 HEX U H32  1 
HETATM 4542 H H41  . HEX O  4 .   ? 98.727  106.001 116.579 1.00 20.00  ? 413 HEX U H41  1 
HETATM 4543 H H42  . HEX O  4 .   ? 96.985  105.776 116.721 1.00 20.00  ? 413 HEX U H42  1 
HETATM 4544 H H51  . HEX O  4 .   ? 96.625  106.228 114.535 1.00 20.00  ? 413 HEX U H51  1 
HETATM 4545 H H52  . HEX O  4 .   ? 97.781  107.553 114.515 1.00 20.00  ? 413 HEX U H52  1 
HETATM 4546 H H61  . HEX O  4 .   ? 99.630  106.061 114.225 1.00 20.00  ? 413 HEX U H61  1 
HETATM 4547 H H62  . HEX O  4 .   ? 98.394  105.596 113.047 1.00 20.00  ? 413 HEX U H62  1 
HETATM 4548 H H63  . HEX O  4 .   ? 98.615  104.648 114.525 1.00 20.00  ? 413 HEX U H63  1 
HETATM 4549 C C1   . EIC P  5 .   ? 126.305 135.980 109.299 1.00 20.00  ? 414 EIC U C1   1 
HETATM 4550 C C2   . EIC P  5 .   ? 126.595 135.394 110.679 1.00 20.00  ? 414 EIC U C2   1 
HETATM 4551 C C3   . EIC P  5 .   ? 125.468 134.524 111.263 1.00 20.00  ? 414 EIC U C3   1 
HETATM 4552 C C4   . EIC P  5 .   ? 126.042 133.515 112.263 1.00 20.00  ? 414 EIC U C4   1 
HETATM 4553 C C5   . EIC P  5 .   ? 124.975 132.511 112.717 1.00 20.00  ? 414 EIC U C5   1 
HETATM 4554 C C6   . EIC P  5 .   ? 124.463 132.824 114.132 1.00 20.00  ? 414 EIC U C6   1 
HETATM 4555 C C7   . EIC P  5 .   ? 124.645 131.646 115.102 1.00 20.00  ? 414 EIC U C7   1 
HETATM 4556 C C8   . EIC P  5 .   ? 125.119 132.106 116.489 1.00 20.00  ? 414 EIC U C8   1 
HETATM 4557 C C9   . EIC P  5 .   ? 124.951 130.980 117.483 1.00 20.00  ? 414 EIC U C9   1 
HETATM 4558 C C10  . EIC P  5 .   ? 125.729 130.658 118.521 1.00 20.00  ? 414 EIC U C10  1 
HETATM 4559 C C11  . EIC P  5 .   ? 126.993 131.331 119.002 1.00 20.00  ? 414 EIC U C11  1 
HETATM 4560 C C12  . EIC P  5 .   ? 127.204 131.014 120.468 1.00 20.00  ? 414 EIC U C12  1 
HETATM 4561 C C13  . EIC P  5 .   ? 127.650 131.819 121.438 1.00 20.00  ? 414 EIC U C13  1 
HETATM 4562 C C14  . EIC P  5 .   ? 128.060 133.267 121.315 1.00 20.00  ? 414 EIC U C14  1 
HETATM 4563 C C15  . EIC P  5 .   ? 128.508 133.823 122.674 1.00 20.00  ? 414 EIC U C15  1 
HETATM 4564 C C16  . EIC P  5 .   ? 129.120 135.225 122.535 1.00 20.00  ? 414 EIC U C16  1 
HETATM 4565 C C17  . EIC P  5 .   ? 128.068 136.314 122.777 1.00 20.00  ? 414 EIC U C17  1 
HETATM 4566 C C18  . EIC P  5 .   ? 128.608 137.705 122.432 1.00 20.00  ? 414 EIC U C18  1 
HETATM 4567 O O1   . EIC P  5 .   ? 125.157 136.183 108.975 1.00 20.00  ? 414 EIC U O1   1 
HETATM 4568 O O2   . EIC P  5 .   ? 127.259 136.209 108.595 1.00 20.00  ? 414 EIC U O2   1 
HETATM 4569 H H21  . EIC P  5 .   ? 127.512 134.798 110.601 1.00 20.00  ? 414 EIC U H21  1 
HETATM 4570 H H22  . EIC P  5 .   ? 126.805 136.226 111.362 1.00 20.00  ? 414 EIC U H22  1 
HETATM 4571 H H31  . EIC P  5 .   ? 124.951 133.993 110.453 1.00 20.00  ? 414 EIC U H31  1 
HETATM 4572 H H32  . EIC P  5 .   ? 124.729 135.165 111.763 1.00 20.00  ? 414 EIC U H32  1 
HETATM 4573 H H41  . EIC P  5 .   ? 126.453 134.051 113.126 1.00 20.00  ? 414 EIC U H41  1 
HETATM 4574 H H42  . EIC P  5 .   ? 126.875 132.977 111.793 1.00 20.00  ? 414 EIC U H42  1 
HETATM 4575 H H51  . EIC P  5 .   ? 125.392 131.498 112.674 1.00 20.00  ? 414 EIC U H51  1 
HETATM 4576 H H52  . EIC P  5 .   ? 124.134 132.540 112.013 1.00 20.00  ? 414 EIC U H52  1 
HETATM 4577 H H61  . EIC P  5 .   ? 123.398 133.088 114.072 1.00 20.00  ? 414 EIC U H61  1 
HETATM 4578 H H62  . EIC P  5 .   ? 124.986 133.703 114.530 1.00 20.00  ? 414 EIC U H62  1 
HETATM 4579 H H71  . EIC P  5 .   ? 125.381 130.947 114.686 1.00 20.00  ? 414 EIC U H71  1 
HETATM 4580 H H72  . EIC P  5 .   ? 123.697 131.104 115.206 1.00 20.00  ? 414 EIC U H72  1 
HETATM 4581 H H81  . EIC P  5 .   ? 126.175 132.395 116.432 1.00 20.00  ? 414 EIC U H81  1 
HETATM 4582 H H82  . EIC P  5 .   ? 124.565 133.003 116.781 1.00 20.00  ? 414 EIC U H82  1 
HETATM 4583 H H91  . EIC P  5 .   ? 124.072 130.367 117.293 1.00 20.00  ? 414 EIC U H91  1 
HETATM 4584 H H1O1 . EIC P  5 .   ? 125.444 129.800 119.131 1.00 20.00  ? 414 EIC U H1O1 1 
HETATM 4585 H H111 . EIC P  5 .   ? 126.942 132.417 118.877 1.00 20.00  ? 414 EIC U H111 1 
HETATM 4586 H H112 . EIC P  5 .   ? 127.827 130.979 118.385 1.00 20.00  ? 414 EIC U H112 1 
HETATM 4587 H H121 . EIC P  5 .   ? 126.950 129.986 120.726 1.00 20.00  ? 414 EIC U H121 1 
HETATM 4588 H H131 . EIC P  5 .   ? 127.742 131.422 122.448 1.00 20.00  ? 414 EIC U H131 1 
HETATM 4589 H H141 . EIC P  5 .   ? 128.867 133.401 120.588 1.00 20.00  ? 414 EIC U H141 1 
HETATM 4590 H H142 . EIC P  5 .   ? 127.208 133.857 120.950 1.00 20.00  ? 414 EIC U H142 1 
HETATM 4591 H H151 . EIC P  5 .   ? 129.239 133.136 123.119 1.00 20.00  ? 414 EIC U H151 1 
HETATM 4592 H H152 . EIC P  5 .   ? 127.643 133.873 123.348 1.00 20.00  ? 414 EIC U H152 1 
HETATM 4593 H H161 . EIC P  5 .   ? 129.535 135.343 121.524 1.00 20.00  ? 414 EIC U H161 1 
HETATM 4594 H H162 . EIC P  5 .   ? 129.947 135.344 123.248 1.00 20.00  ? 414 EIC U H162 1 
HETATM 4595 H H171 . EIC P  5 .   ? 127.755 136.293 123.828 1.00 20.00  ? 414 EIC U H171 1 
HETATM 4596 H H172 . EIC P  5 .   ? 127.181 136.111 122.169 1.00 20.00  ? 414 EIC U H172 1 
HETATM 4597 H H181 . EIC P  5 .   ? 129.529 137.903 122.992 1.00 20.00  ? 414 EIC U H181 1 
HETATM 4598 H H182 . EIC P  5 .   ? 128.833 137.782 121.361 1.00 20.00  ? 414 EIC U H182 1 
HETATM 4599 H H183 . EIC P  5 .   ? 127.877 138.484 122.691 1.00 20.00  ? 414 EIC U H183 1 
HETATM 4600 C C1   . D12 Q  2 .   ? 128.039 143.367 133.539 1.00 20.00  ? 415 D12 U C1   1 
HETATM 4601 C C2   . D12 Q  2 .   ? 128.151 142.903 132.089 1.00 20.00  ? 415 D12 U C2   1 
HETATM 4602 C C3   . D12 Q  2 .   ? 128.438 141.409 131.983 1.00 20.00  ? 415 D12 U C3   1 
HETATM 4603 C C4   . D12 Q  2 .   ? 127.488 140.698 131.023 1.00 20.00  ? 415 D12 U C4   1 
HETATM 4604 C C5   . D12 Q  2 .   ? 127.628 141.193 129.584 1.00 20.00  ? 415 D12 U C5   1 
HETATM 4605 C C6   . D12 Q  2 .   ? 127.455 140.070 128.565 1.00 20.00  ? 415 D12 U C6   1 
HETATM 4606 C C7   . D12 Q  2 .   ? 126.738 140.540 127.303 1.00 20.00  ? 415 D12 U C7   1 
HETATM 4607 C C8   . D12 Q  2 .   ? 126.481 139.394 126.325 1.00 20.00  ? 415 D12 U C8   1 
HETATM 4608 C C9   . D12 Q  2 .   ? 125.047 139.380 125.793 1.00 20.00  ? 415 D12 U C9   1 
HETATM 4609 C C10  . D12 Q  2 .   ? 124.623 138.015 125.252 1.00 20.00  ? 415 D12 U C10  1 
HETATM 4610 C C11  . D12 Q  2 .   ? 123.135 137.749 125.474 1.00 20.00  ? 415 D12 U C11  1 
HETATM 4611 C C12  . D12 Q  2 .   ? 122.606 136.602 124.617 1.00 20.00  ? 415 D12 U C12  1 
HETATM 4612 H H11  . D12 Q  2 .   ? 127.637 144.376 133.565 1.00 20.00  ? 415 D12 U H11  1 
HETATM 4613 H H12  . D12 Q  2 .   ? 129.022 143.356 134.000 1.00 20.00  ? 415 D12 U H12  1 
HETATM 4614 H H13  . D12 Q  2 .   ? 127.376 142.701 134.084 1.00 20.00  ? 415 D12 U H13  1 
HETATM 4615 H H21  . D12 Q  2 .   ? 128.953 143.450 131.606 1.00 20.00  ? 415 D12 U H21  1 
HETATM 4616 H H22  . D12 Q  2 .   ? 127.219 143.119 131.578 1.00 20.00  ? 415 D12 U H22  1 
HETATM 4617 H H31  . D12 Q  2 .   ? 128.341 140.960 132.967 1.00 20.00  ? 415 D12 U H31  1 
HETATM 4618 H H32  . D12 Q  2 .   ? 129.456 141.271 131.634 1.00 20.00  ? 415 D12 U H32  1 
HETATM 4619 H H41  . D12 Q  2 .   ? 126.468 140.864 131.353 1.00 20.00  ? 415 D12 U H41  1 
HETATM 4620 H H42  . D12 Q  2 .   ? 127.697 139.635 131.052 1.00 20.00  ? 415 D12 U H42  1 
HETATM 4621 H H51  . D12 Q  2 .   ? 126.877 141.954 129.400 1.00 20.00  ? 415 D12 U H51  1 
HETATM 4622 H H52  . D12 Q  2 .   ? 128.612 141.633 129.459 1.00 20.00  ? 415 D12 U H52  1 
HETATM 4623 H H61  . D12 Q  2 .   ? 128.433 139.688 128.292 1.00 20.00  ? 415 D12 U H61  1 
HETATM 4624 H H62  . D12 Q  2 .   ? 126.878 139.268 129.015 1.00 20.00  ? 415 D12 U H62  1 
HETATM 4625 H H71  . D12 Q  2 .   ? 125.792 140.990 127.584 1.00 20.00  ? 415 D12 U H71  1 
HETATM 4626 H H72  . D12 Q  2 .   ? 127.349 141.289 126.811 1.00 20.00  ? 415 D12 U H72  1 
HETATM 4627 H H81  . D12 Q  2 .   ? 126.679 138.456 126.832 1.00 20.00  ? 415 D12 U H81  1 
HETATM 4628 H H82  . D12 Q  2 .   ? 127.163 139.490 125.487 1.00 20.00  ? 415 D12 U H82  1 
HETATM 4629 H H91  . D12 Q  2 .   ? 124.965 140.111 124.995 1.00 20.00  ? 415 D12 U H91  1 
HETATM 4630 H H92  . D12 Q  2 .   ? 124.369 139.657 126.593 1.00 20.00  ? 415 D12 U H92  1 
HETATM 4631 H H101 . D12 Q  2 .   ? 124.831 137.978 124.188 1.00 20.00  ? 415 D12 U H101 1 
HETATM 4632 H H102 . D12 Q  2 .   ? 125.194 137.239 125.749 1.00 20.00  ? 415 D12 U H102 1 
HETATM 4633 H H111 . D12 Q  2 .   ? 122.580 138.649 125.234 1.00 20.00  ? 415 D12 U H111 1 
HETATM 4634 H H112 . D12 Q  2 .   ? 122.975 137.507 126.519 1.00 20.00  ? 415 D12 U H112 1 
HETATM 4635 H H121 . D12 Q  2 .   ? 122.693 136.865 123.567 1.00 20.00  ? 415 D12 U H121 1 
HETATM 4636 H H122 . D12 Q  2 .   ? 123.186 135.705 124.814 1.00 20.00  ? 415 D12 U H122 1 
HETATM 4637 H H123 . D12 Q  2 .   ? 121.564 136.421 124.858 1.00 20.00  ? 415 D12 U H123 1 
HETATM 4638 C C1   . OCT R  3 .   ? 122.991 141.363 136.532 1.00 20.00  ? 416 OCT U C1   1 
HETATM 4639 C C2   . OCT R  3 .   ? 122.548 140.653 135.255 1.00 20.00  ? 416 OCT U C2   1 
HETATM 4640 C C3   . OCT R  3 .   ? 123.185 141.262 134.010 1.00 20.00  ? 416 OCT U C3   1 
HETATM 4641 C C4   . OCT R  3 .   ? 123.191 140.295 132.832 1.00 20.00  ? 416 OCT U C4   1 
HETATM 4642 C C5   . OCT R  3 .   ? 121.798 140.059 132.254 1.00 20.00  ? 416 OCT U C5   1 
HETATM 4643 C C6   . OCT R  3 .   ? 121.736 140.403 130.768 1.00 20.00  ? 416 OCT U C6   1 
HETATM 4644 C C7   . OCT R  3 .   ? 120.470 139.871 130.102 1.00 20.00  ? 416 OCT U C7   1 
HETATM 4645 C C8   . OCT R  3 .   ? 120.377 140.282 128.634 1.00 20.00  ? 416 OCT U C8   1 
HETATM 4646 H H11  . OCT R  3 .   ? 122.568 140.857 137.391 1.00 20.00  ? 416 OCT U H11  1 
HETATM 4647 H H12  . OCT R  3 .   ? 124.072 141.345 136.598 1.00 20.00  ? 416 OCT U H12  1 
HETATM 4648 H H13  . OCT R  3 .   ? 122.647 142.390 136.511 1.00 20.00  ? 416 OCT U H13  1 
HETATM 4649 H H21  . OCT R  3 .   ? 121.471 140.723 135.169 1.00 20.00  ? 416 OCT U H21  1 
HETATM 4650 H H22  . OCT R  3 .   ? 122.829 139.609 135.319 1.00 20.00  ? 416 OCT U H22  1 
HETATM 4651 H H31  . OCT R  3 .   ? 122.632 142.152 133.732 1.00 20.00  ? 416 OCT U H31  1 
HETATM 4652 H H32  . OCT R  3 .   ? 124.205 141.542 134.239 1.00 20.00  ? 416 OCT U H32  1 
HETATM 4653 H H41  . OCT R  3 .   ? 123.828 140.698 132.054 1.00 20.00  ? 416 OCT U H41  1 
HETATM 4654 H H42  . OCT R  3 .   ? 123.598 139.346 133.159 1.00 20.00  ? 416 OCT U H42  1 
HETATM 4655 H H51  . OCT R  3 .   ? 121.085 140.673 132.788 1.00 20.00  ? 416 OCT U H51  1 
HETATM 4656 H H52  . OCT R  3 .   ? 121.535 139.016 132.385 1.00 20.00  ? 416 OCT U H52  1 
HETATM 4657 H H61  . OCT R  3 .   ? 121.765 141.480 130.656 1.00 20.00  ? 416 OCT U H61  1 
HETATM 4658 H H62  . OCT R  3 .   ? 122.597 139.974 130.271 1.00 20.00  ? 416 OCT U H62  1 
HETATM 4659 H H71  . OCT R  3 .   ? 120.468 138.790 130.165 1.00 20.00  ? 416 OCT U H71  1 
HETATM 4660 H H72  . OCT R  3 .   ? 119.607 140.257 130.630 1.00 20.00  ? 416 OCT U H72  1 
HETATM 4661 H H81  . OCT R  3 .   ? 120.299 141.360 128.566 1.00 20.00  ? 416 OCT U H81  1 
HETATM 4662 H H82  . OCT R  3 .   ? 121.264 139.949 128.110 1.00 20.00  ? 416 OCT U H82  1 
HETATM 4663 H H83  . OCT R  3 .   ? 119.502 139.827 128.188 1.00 20.00  ? 416 OCT U H83  1 
HETATM 4664 C C1   . HEX S  4 .   ? 112.554 140.464 131.961 1.00 20.00  ? 417 HEX U C1   1 
HETATM 4665 C C2   . HEX S  4 .   ? 111.050 140.343 132.193 1.00 20.00  ? 417 HEX U C2   1 
HETATM 4666 C C3   . HEX S  4 .   ? 110.684 140.378 133.674 1.00 20.00  ? 417 HEX U C3   1 
HETATM 4667 C C4   . HEX S  4 .   ? 109.405 141.169 133.939 1.00 20.00  ? 417 HEX U C4   1 
HETATM 4668 C C5   . HEX S  4 .   ? 108.751 140.784 135.264 1.00 20.00  ? 417 HEX U C5   1 
HETATM 4669 C C6   . HEX S  4 .   ? 107.381 141.433 135.448 1.00 20.00  ? 417 HEX U C6   1 
HETATM 4670 H H11  . HEX S  4 .   ? 112.917 141.380 132.409 1.00 20.00  ? 417 HEX U H11  1 
HETATM 4671 H H12  . HEX S  4 .   ? 112.754 140.479 130.896 1.00 20.00  ? 417 HEX U H12  1 
HETATM 4672 H H13  . HEX S  4 .   ? 113.058 139.617 132.411 1.00 20.00  ? 417 HEX U H13  1 
HETATM 4673 H H21  . HEX S  4 .   ? 110.705 139.407 131.769 1.00 20.00  ? 417 HEX U H21  1 
HETATM 4674 H H22  . HEX S  4 .   ? 110.550 141.161 131.689 1.00 20.00  ? 417 HEX U H22  1 
HETATM 4675 H H31  . HEX S  4 .   ? 111.497 140.834 134.225 1.00 20.00  ? 417 HEX U H31  1 
HETATM 4676 H H32  . HEX S  4 .   ? 110.547 139.363 134.026 1.00 20.00  ? 417 HEX U H32  1 
HETATM 4677 H H41  . HEX S  4 .   ? 109.644 142.226 133.960 1.00 20.00  ? 417 HEX U H41  1 
HETATM 4678 H H42  . HEX S  4 .   ? 108.704 140.985 133.135 1.00 20.00  ? 417 HEX U H42  1 
HETATM 4679 H H51  . HEX S  4 .   ? 108.635 139.708 135.297 1.00 20.00  ? 417 HEX U H51  1 
HETATM 4680 H H52  . HEX S  4 .   ? 109.397 141.093 136.077 1.00 20.00  ? 417 HEX U H52  1 
HETATM 4681 H H61  . HEX S  4 .   ? 107.458 142.497 135.264 1.00 20.00  ? 417 HEX U H61  1 
HETATM 4682 H H62  . HEX S  4 .   ? 107.035 141.264 136.460 1.00 20.00  ? 417 HEX U H62  1 
HETATM 4683 H H63  . HEX S  4 .   ? 106.678 140.995 134.750 1.00 20.00  ? 417 HEX U H63  1 
HETATM 4684 C C1   . OCT T  3 .   ? 117.318 99.256  136.448 1.00 20.00  ? 401 OCT A C1   1 
HETATM 4685 C C2   . OCT T  3 .   ? 117.392 98.984  134.948 1.00 20.00  ? 401 OCT A C2   1 
HETATM 4686 C C3   . OCT T  3 .   ? 117.856 100.205 134.162 1.00 20.00  ? 401 OCT A C3   1 
HETATM 4687 C C4   . OCT T  3 .   ? 117.713 100.005 132.657 1.00 20.00  ? 401 OCT A C4   1 
HETATM 4688 C C5   . OCT T  3 .   ? 119.008 100.305 131.909 1.00 20.00  ? 401 OCT A C5   1 
HETATM 4689 C C6   . OCT T  3 .   ? 118.838 100.194 130.397 1.00 20.00  ? 401 OCT A C6   1 
HETATM 4690 C C7   . OCT T  3 .   ? 120.061 100.702 129.639 1.00 20.00  ? 401 OCT A C7   1 
HETATM 4691 C C8   . OCT T  3 .   ? 120.100 100.191 128.201 1.00 20.00  ? 401 OCT A C8   1 
HETATM 4692 H H11  . OCT T  3 .   ? 117.046 98.345  136.967 1.00 20.00  ? 401 OCT A H11  1 
HETATM 4693 H H12  . OCT T  3 .   ? 118.283 99.597  136.800 1.00 20.00  ? 401 OCT A H12  1 
HETATM 4694 H H13  . OCT T  3 .   ? 116.573 100.018 136.641 1.00 20.00  ? 401 OCT A H13  1 
HETATM 4695 H H21  . OCT T  3 .   ? 116.410 98.693  134.596 1.00 20.00  ? 401 OCT A H21  1 
HETATM 4696 H H22  . OCT T  3 .   ? 118.085 98.170  134.772 1.00 20.00  ? 401 OCT A H22  1 
HETATM 4697 H H31  . OCT T  3 .   ? 117.264 101.062 134.460 1.00 20.00  ? 401 OCT A H31  1 
HETATM 4698 H H32  . OCT T  3 .   ? 118.897 100.399 134.393 1.00 20.00  ? 401 OCT A H32  1 
HETATM 4699 H H41  . OCT T  3 .   ? 117.425 98.979  132.464 1.00 20.00  ? 401 OCT A H41  1 
HETATM 4700 H H42  . OCT T  3 .   ? 116.935 100.662 132.287 1.00 20.00  ? 401 OCT A H42  1 
HETATM 4701 H H51  . OCT T  3 .   ? 119.769 99.604  132.230 1.00 20.00  ? 401 OCT A H51  1 
HETATM 4702 H H52  . OCT T  3 .   ? 119.331 101.310 132.154 1.00 20.00  ? 401 OCT A H52  1 
HETATM 4703 H H61  . OCT T  3 .   ? 118.672 99.156  130.139 1.00 20.00  ? 401 OCT A H61  1 
HETATM 4704 H H62  . OCT T  3 .   ? 117.974 100.774 130.098 1.00 20.00  ? 401 OCT A H62  1 
HETATM 4705 H H71  . OCT T  3 .   ? 120.042 101.785 129.627 1.00 20.00  ? 401 OCT A H71  1 
HETATM 4706 H H72  . OCT T  3 .   ? 120.956 100.372 130.154 1.00 20.00  ? 401 OCT A H72  1 
HETATM 4707 H H81  . OCT T  3 .   ? 120.908 100.677 127.668 1.00 20.00  ? 401 OCT A H81  1 
HETATM 4708 H H82  . OCT T  3 .   ? 120.263 99.120  128.203 1.00 20.00  ? 401 OCT A H82  1 
HETATM 4709 H H83  . OCT T  3 .   ? 119.160 100.414 127.714 1.00 20.00  ? 401 OCT A H83  1 
HETATM 4710 C C1   . HEX U  4 .   ? 145.446 123.627 113.523 1.00 20.00  ? 402 HEX A C1   1 
HETATM 4711 C C2   . HEX U  4 .   ? 146.379 124.162 112.440 1.00 20.00  ? 402 HEX A C2   1 
HETATM 4712 C C3   . HEX U  4 .   ? 145.931 123.757 111.038 1.00 20.00  ? 402 HEX A C3   1 
HETATM 4713 C C4   . HEX U  4 .   ? 146.732 124.461 109.946 1.00 20.00  ? 402 HEX A C4   1 
HETATM 4714 C C5   . HEX U  4 .   ? 146.009 124.450 108.601 1.00 20.00  ? 402 HEX A C5   1 
HETATM 4715 C C6   . HEX U  4 .   ? 146.975 124.473 107.419 1.00 20.00  ? 402 HEX A C6   1 
HETATM 4716 H H11  . HEX U  4 .   ? 145.504 122.546 113.549 1.00 20.00  ? 402 HEX A H11  1 
HETATM 4717 H H12  . HEX U  4 .   ? 144.429 123.928 113.305 1.00 20.00  ? 402 HEX A H12  1 
HETATM 4718 H H13  . HEX U  4 .   ? 145.743 124.028 114.485 1.00 20.00  ? 402 HEX A H13  1 
HETATM 4719 H H21  . HEX U  4 .   ? 147.376 123.776 112.614 1.00 20.00  ? 402 HEX A H21  1 
HETATM 4720 H H22  . HEX U  4 .   ? 146.405 125.243 112.502 1.00 20.00  ? 402 HEX A H22  1 
HETATM 4721 H H31  . HEX U  4 .   ? 144.884 124.006 110.920 1.00 20.00  ? 402 HEX A H31  1 
HETATM 4722 H H32  . HEX U  4 .   ? 146.052 122.687 110.926 1.00 20.00  ? 402 HEX A H32  1 
HETATM 4723 H H41  . HEX U  4 .   ? 146.904 125.489 110.243 1.00 20.00  ? 402 HEX A H41  1 
HETATM 4724 H H42  . HEX U  4 .   ? 147.687 123.964 109.834 1.00 20.00  ? 402 HEX A H42  1 
HETATM 4725 H H51  . HEX U  4 .   ? 145.400 123.557 108.538 1.00 20.00  ? 402 HEX A H51  1 
HETATM 4726 H H52  . HEX U  4 .   ? 145.365 125.319 108.543 1.00 20.00  ? 402 HEX A H52  1 
HETATM 4727 H H61  . HEX U  4 .   ? 146.429 124.696 106.512 1.00 20.00  ? 402 HEX A H61  1 
HETATM 4728 H H62  . HEX U  4 .   ? 147.452 123.505 107.326 1.00 20.00  ? 402 HEX A H62  1 
HETATM 4729 H H63  . HEX U  4 .   ? 147.728 125.233 107.584 1.00 20.00  ? 402 HEX A H63  1 
HETATM 4730 C C27  . R16 V  6 .   ? 104.942 113.476 124.292 1.00 20.00  ? 403 R16 A C27  1 
HETATM 4731 C C28  . R16 V  6 .   ? 104.348 113.077 125.617 1.00 20.00  ? 403 R16 A C28  1 
HETATM 4732 C C29  . R16 V  6 .   ? 103.507 114.192 126.189 1.00 20.00  ? 403 R16 A C29  1 
HETATM 4733 C C30  . R16 V  6 .   ? 102.822 113.748 127.466 1.00 20.00  ? 403 R16 A C30  1 
HETATM 4734 C C31  . R16 V  6 .   ? 102.121 114.899 128.184 1.00 20.00  ? 403 R16 A C31  1 
HETATM 4735 C C32  . R16 V  6 .   ? 101.334 114.408 129.401 1.00 20.00  ? 403 R16 A C32  1 
HETATM 4736 C C33  . R16 V  6 .   ? 100.232 115.391 129.798 1.00 20.00  ? 403 R16 A C33  1 
HETATM 4737 C C34  . R16 V  6 .   ? 99.588  115.017 131.135 1.00 20.00  ? 403 R16 A C34  1 
HETATM 4738 C C35  . R16 V  6 .   ? 98.612  116.088 131.620 1.00 20.00  ? 403 R16 A C35  1 
HETATM 4739 C C36  . R16 V  6 .   ? 98.393  116.012 133.129 1.00 20.00  ? 403 R16 A C36  1 
HETATM 4740 C C37  . R16 V  6 .   ? 97.832  117.322 133.673 1.00 20.00  ? 403 R16 A C37  1 
HETATM 4741 C C38  . R16 V  6 .   ? 97.773  117.330 135.194 1.00 20.00  ? 403 R16 A C38  1 
HETATM 4742 C C39  . R16 V  6 .   ? 99.147  117.560 135.798 1.00 20.00  ? 403 R16 A C39  1 
HETATM 4743 C C40  . R16 V  6 .   ? 99.193  118.800 136.643 1.00 20.00  ? 403 R16 A C40  1 
HETATM 4744 C C41  . R16 V  6 .   ? 98.624  118.535 138.011 1.00 20.00  ? 403 R16 A C41  1 
HETATM 4745 C C42  . R16 V  6 .   ? 99.720  118.597 139.039 1.00 20.00  ? 403 R16 A C42  1 
HETATM 4746 H H271 . R16 V  6 .   ? 104.399 113.051 123.437 1.00 20.00  ? 403 R16 A H271 1 
HETATM 4747 H H272 . R16 V  6 .   ? 104.951 114.564 124.152 1.00 20.00  ? 403 R16 A H272 1 
HETATM 4748 H H273 . R16 V  6 .   ? 105.983 113.142 124.184 1.00 20.00  ? 403 R16 A H273 1 
HETATM 4749 H H281 . R16 V  6 .   ? 105.156 112.804 126.323 1.00 20.00  ? 403 R16 A H281 1 
HETATM 4750 H H282 . R16 V  6 .   ? 103.753 112.150 125.509 1.00 20.00  ? 403 R16 A H282 1 
HETATM 4751 H H291 . R16 V  6 .   ? 104.144 115.080 126.378 1.00 20.00  ? 403 R16 A H291 1 
HETATM 4752 H H292 . R16 V  6 .   ? 102.770 114.536 125.441 1.00 20.00  ? 403 R16 A H292 1 
HETATM 4753 H H301 . R16 V  6 .   ? 102.099 112.942 127.238 1.00 20.00  ? 403 R16 A H301 1 
HETATM 4754 H H302 . R16 V  6 .   ? 103.560 113.272 128.145 1.00 20.00  ? 403 R16 A H302 1 
HETATM 4755 H H311 . R16 V  6 .   ? 102.858 115.666 128.492 1.00 20.00  ? 403 R16 A H311 1 
HETATM 4756 H H312 . R16 V  6 .   ? 101.447 115.431 127.481 1.00 20.00  ? 403 R16 A H312 1 
HETATM 4757 H H321 . R16 V  6 .   ? 100.904 113.407 129.194 1.00 20.00  ? 403 R16 A H321 1 
HETATM 4758 H H322 . R16 V  6 .   ? 102.016 114.238 130.258 1.00 20.00  ? 403 R16 A H322 1 
HETATM 4759 H H331 . R16 V  6 .   ? 100.644 116.418 129.844 1.00 20.00  ? 403 R16 A H331 1 
HETATM 4760 H H332 . R16 V  6 .   ? 99.457  115.439 129.007 1.00 20.00  ? 403 R16 A H332 1 
HETATM 4761 H H341 . R16 V  6 .   ? 100.378 114.848 131.895 1.00 20.00  ? 403 R16 A H341 1 
HETATM 4762 H H342 . R16 V  6 .   ? 99.072  114.040 131.052 1.00 20.00  ? 403 R16 A H342 1 
HETATM 4763 H H351 . R16 V  6 .   ? 97.645  115.994 131.091 1.00 20.00  ? 403 R16 A H351 1 
HETATM 4764 H H352 . R16 V  6 .   ? 98.984  117.092 131.339 1.00 20.00  ? 403 R16 A H352 1 
HETATM 4765 H H361 . R16 V  6 .   ? 99.346  115.763 133.637 1.00 20.00  ? 403 R16 A H361 1 
HETATM 4766 H H362 . R16 V  6 .   ? 97.716  115.174 133.383 1.00 20.00  ? 403 R16 A H362 1 
HETATM 4767 H H371 . R16 V  6 .   ? 96.824  117.507 133.255 1.00 20.00  ? 403 R16 A H371 1 
HETATM 4768 H H372 . R16 V  6 .   ? 98.440  118.173 133.314 1.00 20.00  ? 403 R16 A H372 1 
HETATM 4769 H H381 . R16 V  6 .   ? 97.351  116.376 135.566 1.00 20.00  ? 403 R16 A H381 1 
HETATM 4770 H H382 . R16 V  6 .   ? 97.063  118.102 135.546 1.00 20.00  ? 403 R16 A H382 1 
HETATM 4771 H H391 . R16 V  6 .   ? 99.443  116.680 136.405 1.00 20.00  ? 403 R16 A H391 1 
HETATM 4772 H H392 . R16 V  6 .   ? 99.913  117.617 135.000 1.00 20.00  ? 403 R16 A H392 1 
HETATM 4773 H H401 . R16 V  6 .   ? 98.646  119.627 136.152 1.00 20.00  ? 403 R16 A H401 1 
HETATM 4774 H H402 . R16 V  6 .   ? 100.234 119.166 136.736 1.00 20.00  ? 403 R16 A H402 1 
HETATM 4775 H H411 . R16 V  6 .   ? 98.122  117.545 138.044 1.00 20.00  ? 403 R16 A H411 1 
HETATM 4776 H H412 . R16 V  6 .   ? 97.835  119.275 138.240 1.00 20.00  ? 403 R16 A H412 1 
HETATM 4777 H H421 . R16 V  6 .   ? 100.501 117.851 138.844 1.00 20.00  ? 403 R16 A H421 1 
HETATM 4778 H H422 . R16 V  6 .   ? 100.230 119.568 139.061 1.00 20.00  ? 403 R16 A H422 1 
HETATM 4779 H H423 . R16 V  6 .   ? 99.357  118.400 140.056 1.00 20.00  ? 403 R16 A H423 1 
HETATM 4780 C C1   . D12 W  2 .   ? 108.943 99.493  119.413 1.00 20.00  ? 404 D12 A C1   1 
HETATM 4781 C C2   . D12 W  2 .   ? 109.470 100.050 118.093 1.00 20.00  ? 404 D12 A C2   1 
HETATM 4782 C C3   . D12 W  2 .   ? 108.346 100.337 117.102 1.00 20.00  ? 404 D12 A C3   1 
HETATM 4783 C C4   . D12 W  2 .   ? 108.778 101.274 115.979 1.00 20.00  ? 404 D12 A C4   1 
HETATM 4784 C C5   . D12 W  2 .   ? 109.715 100.606 114.977 1.00 20.00  ? 404 D12 A C5   1 
HETATM 4785 C C6   . D12 W  2 .   ? 108.951 99.970  113.819 1.00 20.00  ? 404 D12 A C6   1 
HETATM 4786 C C7   . D12 W  2 .   ? 108.920 100.859 112.579 1.00 20.00  ? 404 D12 A C7   1 
HETATM 4787 C C8   . D12 W  2 .   ? 110.175 100.704 111.725 1.00 20.00  ? 404 D12 A C8   1 
HETATM 4788 C C9   . D12 W  2 .   ? 110.138 99.427  110.892 1.00 20.00  ? 404 D12 A C9   1 
HETATM 4789 C C10  . D12 W  2 .   ? 109.902 99.699  109.409 1.00 20.00  ? 404 D12 A C10  1 
HETATM 4790 C C11  . D12 W  2 .   ? 109.432 98.451  108.667 1.00 20.00  ? 404 D12 A C11  1 
HETATM 4791 C C12  . D12 W  2 .   ? 109.205 98.705  107.178 1.00 20.00  ? 404 D12 A C12  1 
HETATM 4792 H H11  . D12 W  2 .   ? 108.103 100.094 119.750 1.00 20.00  ? 404 D12 A H11  1 
HETATM 4793 H H12  . D12 W  2 .   ? 109.731 99.522  120.159 1.00 20.00  ? 404 D12 A H12  1 
HETATM 4794 H H13  . D12 W  2 .   ? 108.619 98.467  119.269 1.00 20.00  ? 404 D12 A H13  1 
HETATM 4795 H H21  . D12 W  2 .   ? 110.151 99.326  117.656 1.00 20.00  ? 404 D12 A H21  1 
HETATM 4796 H H22  . D12 W  2 .   ? 110.012 100.968 118.290 1.00 20.00  ? 404 D12 A H22  1 
HETATM 4797 H H31  . D12 W  2 .   ? 107.517 100.789 117.636 1.00 20.00  ? 404 D12 A H31  1 
HETATM 4798 H H32  . D12 W  2 .   ? 108.015 99.400  116.669 1.00 20.00  ? 404 D12 A H32  1 
HETATM 4799 H H41  . D12 W  2 .   ? 109.286 102.130 116.413 1.00 20.00  ? 404 D12 A H41  1 
HETATM 4800 H H42  . D12 W  2 .   ? 107.894 101.623 115.456 1.00 20.00  ? 404 D12 A H42  1 
HETATM 4801 H H51  . D12 W  2 .   ? 110.396 101.352 114.580 1.00 20.00  ? 404 D12 A H51  1 
HETATM 4802 H H52  . D12 W  2 .   ? 110.291 99.838  115.481 1.00 20.00  ? 404 D12 A H52  1 
HETATM 4803 H H61  . D12 W  2 .   ? 109.424 99.028  113.565 1.00 20.00  ? 404 D12 A H61  1 
HETATM 4804 H H62  . D12 W  2 .   ? 107.931 99.774  114.136 1.00 20.00  ? 404 D12 A H62  1 
HETATM 4805 H H71  . D12 W  2 .   ? 108.053 100.597 111.981 1.00 20.00  ? 404 D12 A H71  1 
HETATM 4806 H H72  . D12 W  2 .   ? 108.832 101.894 112.890 1.00 20.00  ? 404 D12 A H72  1 
HETATM 4807 H H81  . D12 W  2 .   ? 111.043 100.678 112.375 1.00 20.00  ? 404 D12 A H81  1 
HETATM 4808 H H82  . D12 W  2 .   ? 110.257 101.558 111.059 1.00 20.00  ? 404 D12 A H82  1 
HETATM 4809 H H91  . D12 W  2 .   ? 109.341 98.789  111.262 1.00 20.00  ? 404 D12 A H91  1 
HETATM 4810 H H92  . D12 W  2 .   ? 111.084 98.907  111.007 1.00 20.00  ? 404 D12 A H92  1 
HETATM 4811 H H101 . D12 W  2 .   ? 109.150 100.474 109.308 1.00 20.00  ? 404 D12 A H101 1 
HETATM 4812 H H102 . D12 W  2 .   ? 110.828 100.046 108.964 1.00 20.00  ? 404 D12 A H102 1 
HETATM 4813 H H111 . D12 W  2 .   ? 108.501 98.111  109.108 1.00 20.00  ? 404 D12 A H111 1 
HETATM 4814 H H112 . D12 W  2 .   ? 110.179 97.672  108.780 1.00 20.00  ? 404 D12 A H112 1 
HETATM 4815 H H121 . D12 W  2 .   ? 110.148 98.967  106.707 1.00 20.00  ? 404 D12 A H121 1 
HETATM 4816 H H122 . D12 W  2 .   ? 108.806 97.808  106.714 1.00 20.00  ? 404 D12 A H122 1 
HETATM 4817 H H123 . D12 W  2 .   ? 108.500 99.521  107.053 1.00 20.00  ? 404 D12 A H123 1 
HETATM 4818 C C1   . OCT X  3 .   ? 94.758  122.170 107.843 1.00 20.00  ? 405 OCT A C1   1 
HETATM 4819 C C2   . OCT X  3 .   ? 95.080  121.332 109.077 1.00 20.00  ? 405 OCT A C2   1 
HETATM 4820 C C3   . OCT X  3 .   ? 95.394  122.188 110.301 1.00 20.00  ? 405 OCT A C3   1 
HETATM 4821 C C4   . OCT X  3 .   ? 96.430  121.532 111.209 1.00 20.00  ? 405 OCT A C4   1 
HETATM 4822 C C5   . OCT X  3 .   ? 96.833  122.426 112.378 1.00 20.00  ? 405 OCT A C5   1 
HETATM 4823 C C6   . OCT X  3 .   ? 96.429  121.832 113.725 1.00 20.00  ? 405 OCT A C6   1 
HETATM 4824 C C7   . OCT X  3 .   ? 96.936  122.665 114.900 1.00 20.00  ? 405 OCT A C7   1 
HETATM 4825 C C8   . OCT X  3 .   ? 96.521  122.080 116.247 1.00 20.00  ? 405 OCT A C8   1 
HETATM 4826 H H11  . OCT X  3 .   ? 93.955  122.859 108.074 1.00 20.00  ? 405 OCT A H11  1 
HETATM 4827 H H12  . OCT X  3 .   ? 95.638  122.727 107.546 1.00 20.00  ? 405 OCT A H12  1 
HETATM 4828 H H13  . OCT X  3 .   ? 94.454  121.518 107.033 1.00 20.00  ? 405 OCT A H13  1 
HETATM 4829 H H21  . OCT X  3 .   ? 95.935  120.704 108.860 1.00 20.00  ? 405 OCT A H21  1 
HETATM 4830 H H22  . OCT X  3 .   ? 94.229  120.699 109.301 1.00 20.00  ? 405 OCT A H22  1 
HETATM 4831 H H31  . OCT X  3 .   ? 94.482  122.345 110.864 1.00 20.00  ? 405 OCT A H31  1 
HETATM 4832 H H32  . OCT X  3 .   ? 95.772  123.147 109.971 1.00 20.00  ? 405 OCT A H32  1 
HETATM 4833 H H41  . OCT X  3 .   ? 96.018  120.610 111.599 1.00 20.00  ? 405 OCT A H41  1 
HETATM 4834 H H42  . OCT X  3 .   ? 97.312  121.302 110.625 1.00 20.00  ? 405 OCT A H42  1 
HETATM 4835 H H51  . OCT X  3 .   ? 96.356  123.391 112.263 1.00 20.00  ? 405 OCT A H51  1 
HETATM 4836 H H52  . OCT X  3 .   ? 97.907  122.561 112.362 1.00 20.00  ? 405 OCT A H52  1 
HETATM 4837 H H61  . OCT X  3 .   ? 95.348  121.777 113.774 1.00 20.00  ? 405 OCT A H61  1 
HETATM 4838 H H62  . OCT X  3 .   ? 96.836  120.832 113.803 1.00 20.00  ? 405 OCT A H62  1 
HETATM 4839 H H71  . OCT X  3 .   ? 98.017  122.712 114.855 1.00 20.00  ? 405 OCT A H71  1 
HETATM 4840 H H72  . OCT X  3 .   ? 96.536  123.668 114.816 1.00 20.00  ? 405 OCT A H72  1 
HETATM 4841 H H81  . OCT X  3 .   ? 96.962  122.664 117.046 1.00 20.00  ? 405 OCT A H81  1 
HETATM 4842 H H82  . OCT X  3 .   ? 95.442  122.104 116.336 1.00 20.00  ? 405 OCT A H82  1 
HETATM 4843 H H83  . OCT X  3 .   ? 96.866  121.055 116.318 1.00 20.00  ? 405 OCT A H83  1 
HETATM 4844 C C1   . OCT Y  3 .   ? 127.139 94.447  113.564 1.00 20.00  ? 406 OCT A C1   1 
HETATM 4845 C C2   . OCT Y  3 .   ? 126.398 94.183  112.256 1.00 20.00  ? 406 OCT A C2   1 
HETATM 4846 C C3   . OCT Y  3 .   ? 127.306 93.583  111.187 1.00 20.00  ? 406 OCT A C3   1 
HETATM 4847 C C4   . OCT Y  3 .   ? 126.667 93.620  109.801 1.00 20.00  ? 406 OCT A C4   1 
HETATM 4848 C C5   . OCT Y  3 .   ? 127.592 93.065  108.722 1.00 20.00  ? 406 OCT A C5   1 
HETATM 4849 C C6   . OCT Y  3 .   ? 126.998 93.201  107.324 1.00 20.00  ? 406 OCT A C6   1 
HETATM 4850 C C7   . OCT Y  3 .   ? 127.745 92.351  106.300 1.00 20.00  ? 406 OCT A C7   1 
HETATM 4851 C C8   . OCT Y  3 .   ? 127.038 92.312  104.949 1.00 20.00  ? 406 OCT A C8   1 
HETATM 4852 H H11  . OCT Y  3 .   ? 126.435 94.775  114.318 1.00 20.00  ? 406 OCT A H11  1 
HETATM 4853 H H12  . OCT Y  3 .   ? 127.623 93.537  113.894 1.00 20.00  ? 406 OCT A H12  1 
HETATM 4854 H H13  . OCT Y  3 .   ? 127.884 95.217  113.406 1.00 20.00  ? 406 OCT A H13  1 
HETATM 4855 H H21  . OCT Y  3 .   ? 125.992 95.117  111.889 1.00 20.00  ? 406 OCT A H21  1 
HETATM 4856 H H22  . OCT Y  3 .   ? 125.582 93.497  112.449 1.00 20.00  ? 406 OCT A H22  1 
HETATM 4857 H H31  . OCT Y  3 .   ? 128.233 94.142  111.160 1.00 20.00  ? 406 OCT A H31  1 
HETATM 4858 H H32  . OCT Y  3 .   ? 127.522 92.554  111.446 1.00 20.00  ? 406 OCT A H32  1 
HETATM 4859 H H41  . OCT Y  3 .   ? 125.757 93.033  109.818 1.00 20.00  ? 406 OCT A H41  1 
HETATM 4860 H H42  . OCT Y  3 .   ? 126.418 94.645  109.556 1.00 20.00  ? 406 OCT A H42  1 
HETATM 4861 H H51  . OCT Y  3 .   ? 127.778 92.018  108.925 1.00 20.00  ? 406 OCT A H51  1 
HETATM 4862 H H52  . OCT Y  3 .   ? 128.532 93.602  108.757 1.00 20.00  ? 406 OCT A H52  1 
HETATM 4863 H H61  . OCT Y  3 .   ? 125.961 92.888  107.350 1.00 20.00  ? 406 OCT A H61  1 
HETATM 4864 H H62  . OCT Y  3 .   ? 127.044 94.239  107.020 1.00 20.00  ? 406 OCT A H62  1 
HETATM 4865 H H71  . OCT Y  3 .   ? 128.739 92.760  106.164 1.00 20.00  ? 406 OCT A H71  1 
HETATM 4866 H H72  . OCT Y  3 .   ? 127.831 91.340  106.679 1.00 20.00  ? 406 OCT A H72  1 
HETATM 4867 H H81  . OCT Y  3 .   ? 127.632 91.741  104.246 1.00 20.00  ? 406 OCT A H81  1 
HETATM 4868 H H82  . OCT Y  3 .   ? 126.067 91.845  105.063 1.00 20.00  ? 406 OCT A H82  1 
HETATM 4869 H H83  . OCT Y  3 .   ? 126.910 93.321  104.578 1.00 20.00  ? 406 OCT A H83  1 
HETATM 4870 C C1   . D12 Z  2 .   ? 120.519 95.292  116.039 1.00 20.00  ? 407 D12 A C1   1 
HETATM 4871 C C2   . D12 Z  2 .   ? 120.202 94.756  114.646 1.00 20.00  ? 407 D12 A C2   1 
HETATM 4872 C C3   . D12 Z  2 .   ? 121.225 93.724  114.179 1.00 20.00  ? 407 D12 A C3   1 
HETATM 4873 C C4   . D12 Z  2 .   ? 121.724 93.977  112.758 1.00 20.00  ? 407 D12 A C4   1 
HETATM 4874 C C5   . D12 Z  2 .   ? 120.626 93.871  111.703 1.00 20.00  ? 407 D12 A C5   1 
HETATM 4875 C C6   . D12 Z  2 .   ? 121.099 94.345  110.331 1.00 20.00  ? 407 D12 A C6   1 
HETATM 4876 C C7   . D12 Z  2 .   ? 121.171 93.211  109.311 1.00 20.00  ? 407 D12 A C7   1 
HETATM 4877 C C8   . D12 Z  2 .   ? 121.613 93.704  107.936 1.00 20.00  ? 407 D12 A C8   1 
HETATM 4878 C C9   . D12 Z  2 .   ? 121.030 92.863  106.803 1.00 20.00  ? 407 D12 A C9   1 
HETATM 4879 C C10  . D12 Z  2 .   ? 121.908 92.848  105.553 1.00 20.00  ? 407 D12 A C10  1 
HETATM 4880 C C11  . D12 Z  2 .   ? 121.798 91.533  104.787 1.00 20.00  ? 407 D12 A C11  1 
HETATM 4881 C C12  . D12 Z  2 .   ? 122.283 91.659  103.345 1.00 20.00  ? 407 D12 A C12  1 
HETATM 4882 H H11  . D12 Z  2 .   ? 120.806 94.470  116.689 1.00 20.00  ? 407 D12 A H11  1 
HETATM 4883 H H12  . D12 Z  2 .   ? 119.643 95.786  116.445 1.00 20.00  ? 407 D12 A H12  1 
HETATM 4884 H H13  . D12 Z  2 .   ? 121.338 96.003  115.974 1.00 20.00  ? 407 D12 A H13  1 
HETATM 4885 H H21  . D12 Z  2 .   ? 120.192 95.584  113.945 1.00 20.00  ? 407 D12 A H21  1 
HETATM 4886 H H22  . D12 Z  2 .   ? 119.220 94.295  114.661 1.00 20.00  ? 407 D12 A H22  1 
HETATM 4887 H H31  . D12 Z  2 .   ? 120.771 92.740  114.218 1.00 20.00  ? 407 D12 A H31  1 
HETATM 4888 H H32  . D12 Z  2 .   ? 122.074 93.745  114.856 1.00 20.00  ? 407 D12 A H32  1 
HETATM 4889 H H41  . D12 Z  2 .   ? 122.500 93.255  112.527 1.00 20.00  ? 407 D12 A H41  1 
HETATM 4890 H H42  . D12 Z  2 .   ? 122.153 94.974  112.715 1.00 20.00  ? 407 D12 A H42  1 
HETATM 4891 H H51  . D12 Z  2 .   ? 120.311 92.834  111.628 1.00 20.00  ? 407 D12 A H51  1 
HETATM 4892 H H52  . D12 Z  2 .   ? 119.777 94.475  112.006 1.00 20.00  ? 407 D12 A H52  1 
HETATM 4893 H H61  . D12 Z  2 .   ? 120.413 95.102  109.966 1.00 20.00  ? 407 D12 A H61  1 
HETATM 4894 H H62  . D12 Z  2 .   ? 122.086 94.785  110.433 1.00 20.00  ? 407 D12 A H62  1 
HETATM 4895 H H71  . D12 Z  2 .   ? 121.877 92.466  109.662 1.00 20.00  ? 407 D12 A H71  1 
HETATM 4896 H H72  . D12 Z  2 .   ? 120.191 92.755  109.224 1.00 20.00  ? 407 D12 A H72  1 
HETATM 4897 H H81  . D12 Z  2 .   ? 122.696 93.671  107.888 1.00 20.00  ? 407 D12 A H81  1 
HETATM 4898 H H82  . D12 Z  2 .   ? 121.288 94.733  107.811 1.00 20.00  ? 407 D12 A H82  1 
HETATM 4899 H H91  . D12 Z  2 .   ? 120.055 93.261  106.539 1.00 20.00  ? 407 D12 A H91  1 
HETATM 4900 H H92  . D12 Z  2 .   ? 120.907 91.844  107.154 1.00 20.00  ? 407 D12 A H92  1 
HETATM 4901 H H101 . D12 Z  2 .   ? 121.603 93.660  104.901 1.00 20.00  ? 407 D12 A H101 1 
HETATM 4902 H H102 . D12 Z  2 .   ? 122.943 92.998  105.839 1.00 20.00  ? 407 D12 A H102 1 
HETATM 4903 H H111 . D12 Z  2 .   ? 120.761 91.215  104.782 1.00 20.00  ? 407 D12 A H111 1 
HETATM 4904 H H112 . D12 Z  2 .   ? 122.394 90.781  105.293 1.00 20.00  ? 407 D12 A H112 1 
HETATM 4905 H H121 . D12 Z  2 .   ? 121.639 92.347  102.806 1.00 20.00  ? 407 D12 A H121 1 
HETATM 4906 H H122 . D12 Z  2 .   ? 123.301 92.035  103.338 1.00 20.00  ? 407 D12 A H122 1 
HETATM 4907 H H123 . D12 Z  2 .   ? 122.253 90.685  102.866 1.00 20.00  ? 407 D12 A H123 1 
HETATM 4908 C C1   . HEX AA 4 .   ? 103.796 98.577  113.654 1.00 20.00  ? 408 HEX A C1   1 
HETATM 4909 C C2   . HEX AA 4 .   ? 104.060 99.496  112.465 1.00 20.00  ? 408 HEX A C2   1 
HETATM 4910 C C3   . HEX AA 4 .   ? 103.486 98.945  111.162 1.00 20.00  ? 408 HEX A C3   1 
HETATM 4911 C C4   . HEX AA 4 .   ? 104.385 99.239  109.963 1.00 20.00  ? 408 HEX A C4   1 
HETATM 4912 C C5   . HEX AA 4 .   ? 103.599 99.283  108.655 1.00 20.00  ? 408 HEX A C5   1 
HETATM 4913 C C6   . HEX AA 4 .   ? 104.490 99.093  107.432 1.00 20.00  ? 408 HEX A C6   1 
HETATM 4914 H H11  . HEX AA 4 .   ? 104.330 97.644  113.515 1.00 20.00  ? 408 HEX A H11  1 
HETATM 4915 H H12  . HEX AA 4 .   ? 102.734 98.376  113.727 1.00 20.00  ? 408 HEX A H12  1 
HETATM 4916 H H13  . HEX AA 4 .   ? 104.137 99.056  114.563 1.00 20.00  ? 408 HEX A H13  1 
HETATM 4917 H H21  . HEX AA 4 .   ? 105.129 99.623  112.350 1.00 20.00  ? 408 HEX A H21  1 
HETATM 4918 H H22  . HEX AA 4 .   ? 103.613 100.462 112.663 1.00 20.00  ? 408 HEX A H22  1 
HETATM 4919 H H31  . HEX AA 4 .   ? 102.515 99.393  110.990 1.00 20.00  ? 408 HEX A H31  1 
HETATM 4920 H H32  . HEX AA 4 .   ? 103.366 97.874  111.257 1.00 20.00  ? 408 HEX A H32  1 
HETATM 4921 H H41  . HEX AA 4 .   ? 104.871 100.194 110.112 1.00 20.00  ? 408 HEX A H41  1 
HETATM 4922 H H42  . HEX AA 4 .   ? 105.140 98.466  109.892 1.00 20.00  ? 408 HEX A H42  1 
HETATM 4923 H H51  . HEX AA 4 .   ? 102.851 98.500  108.669 1.00 20.00  ? 408 HEX A H51  1 
HETATM 4924 H H52  . HEX AA 4 .   ? 103.099 100.241 108.579 1.00 20.00  ? 408 HEX A H52  1 
HETATM 4925 H H61  . HEX AA 4 .   ? 103.938 99.353  106.538 1.00 20.00  ? 408 HEX A H61  1 
HETATM 4926 H H62  . HEX AA 4 .   ? 104.807 98.058  107.372 1.00 20.00  ? 408 HEX A H62  1 
HETATM 4927 H H63  . HEX AA 4 .   ? 105.361 99.731  107.517 1.00 20.00  ? 408 HEX A H63  1 
HETATM 4928 C C1   . OCT BA 3 .   ? 110.574 94.258  117.374 1.00 20.00  ? 409 OCT A C1   1 
HETATM 4929 C C2   . OCT BA 3 .   ? 111.443 93.800  116.206 1.00 20.00  ? 409 OCT A C2   1 
HETATM 4930 C C3   . OCT BA 3 .   ? 110.915 94.287  114.858 1.00 20.00  ? 409 OCT A C3   1 
HETATM 4931 C C4   . OCT BA 3 .   ? 111.565 93.551  113.690 1.00 20.00  ? 409 OCT A C4   1 
HETATM 4932 C C5   . OCT BA 3 .   ? 110.848 93.800  112.366 1.00 20.00  ? 409 OCT A C5   1 
HETATM 4933 C C6   . OCT BA 3 .   ? 111.038 92.642  111.391 1.00 20.00  ? 409 OCT A C6   1 
HETATM 4934 C C7   . OCT BA 3 .   ? 110.361 92.894  110.048 1.00 20.00  ? 409 OCT A C7   1 
HETATM 4935 C C8   . OCT BA 3 .   ? 110.515 91.708  109.098 1.00 20.00  ? 409 OCT A C8   1 
HETATM 4936 H H11  . OCT BA 3 .   ? 111.032 93.954  118.306 1.00 20.00  ? 409 OCT A H11  1 
HETATM 4937 H H12  . OCT BA 3 .   ? 110.480 95.337  117.353 1.00 20.00  ? 409 OCT A H12  1 
HETATM 4938 H H13  . OCT BA 3 .   ? 109.591 93.809  117.291 1.00 20.00  ? 409 OCT A H13  1 
HETATM 4939 H H21  . OCT BA 3 .   ? 111.477 92.719  116.200 1.00 20.00  ? 409 OCT A H21  1 
HETATM 4940 H H22  . OCT BA 3 .   ? 112.447 94.182  116.346 1.00 20.00  ? 409 OCT A H22  1 
HETATM 4941 H H31  . OCT BA 3 .   ? 109.844 94.128  114.824 1.00 20.00  ? 409 OCT A H31  1 
HETATM 4942 H H32  . OCT BA 3 .   ? 111.118 95.346  114.763 1.00 20.00  ? 409 OCT A H32  1 
HETATM 4943 H H41  . OCT BA 3 .   ? 112.593 93.879  113.598 1.00 20.00  ? 409 OCT A H41  1 
HETATM 4944 H H42  . OCT BA 3 .   ? 111.555 92.488  113.897 1.00 20.00  ? 409 OCT A H42  1 
HETATM 4945 H H51  . OCT BA 3 .   ? 111.241 94.705  111.918 1.00 20.00  ? 409 OCT A H51  1 
HETATM 4946 H H52  . OCT BA 3 .   ? 109.790 93.931  112.555 1.00 20.00  ? 409 OCT A H52  1 
HETATM 4947 H H61  . OCT BA 3 .   ? 112.098 92.493  111.227 1.00 20.00  ? 409 OCT A H61  1 
HETATM 4948 H H62  . OCT BA 3 .   ? 110.622 91.744  111.829 1.00 20.00  ? 409 OCT A H62  1 
HETATM 4949 H H71  . OCT BA 3 .   ? 109.307 93.077  110.213 1.00 20.00  ? 409 OCT A H71  1 
HETATM 4950 H H72  . OCT BA 3 .   ? 110.803 93.770  109.589 1.00 20.00  ? 409 OCT A H72  1 
HETATM 4951 H H81  . OCT BA 3 .   ? 110.130 90.814  109.573 1.00 20.00  ? 409 OCT A H81  1 
HETATM 4952 H H82  . OCT BA 3 .   ? 109.960 91.900  108.188 1.00 20.00  ? 409 OCT A H82  1 
HETATM 4953 H H83  . OCT BA 3 .   ? 111.562 91.569  108.861 1.00 20.00  ? 409 OCT A H83  1 
HETATM 4954 C C1   . HEX CA 4 .   ? 140.253 110.211 113.169 1.00 20.00  ? 410 HEX A C1   1 
HETATM 4955 C C2   . HEX CA 4 .   ? 140.551 109.065 112.205 1.00 20.00  ? 410 HEX A C2   1 
HETATM 4956 C C3   . HEX CA 4 .   ? 141.629 109.425 111.185 1.00 20.00  ? 410 HEX A C3   1 
HETATM 4957 C C4   . HEX CA 4 .   ? 141.224 109.058 109.760 1.00 20.00  ? 410 HEX A C4   1 
HETATM 4958 C C5   . HEX CA 4 .   ? 142.421 108.967 108.819 1.00 20.00  ? 410 HEX A C5   1 
HETATM 4959 C C6   . HEX CA 4 .   ? 142.006 108.999 107.350 1.00 20.00  ? 410 HEX A C6   1 
HETATM 4960 H H11  . HEX CA 4 .   ? 139.558 109.873 113.928 1.00 20.00  ? 410 HEX A H11  1 
HETATM 4961 H H12  . HEX CA 4 .   ? 139.819 111.038 112.624 1.00 20.00  ? 410 HEX A H12  1 
HETATM 4962 H H13  . HEX CA 4 .   ? 141.173 110.533 113.642 1.00 20.00  ? 410 HEX A H13  1 
HETATM 4963 H H21  . HEX CA 4 .   ? 139.641 108.808 111.678 1.00 20.00  ? 410 HEX A H21  1 
HETATM 4964 H H22  . HEX CA 4 .   ? 140.882 108.205 112.775 1.00 20.00  ? 410 HEX A H22  1 
HETATM 4965 H H31  . HEX CA 4 .   ? 142.540 108.897 111.437 1.00 20.00  ? 410 HEX A H31  1 
HETATM 4966 H H32  . HEX CA 4 .   ? 141.817 110.491 111.234 1.00 20.00  ? 410 HEX A H32  1 
HETATM 4967 H H41  . HEX CA 4 .   ? 140.540 109.811 109.386 1.00 20.00  ? 410 HEX A H41  1 
HETATM 4968 H H42  . HEX CA 4 .   ? 140.717 108.101 109.774 1.00 20.00  ? 410 HEX A H42  1 
HETATM 4969 H H51  . HEX CA 4 .   ? 142.951 108.042 109.013 1.00 20.00  ? 410 HEX A H51  1 
HETATM 4970 H H52  . HEX CA 4 .   ? 143.085 109.800 109.015 1.00 20.00  ? 410 HEX A H52  1 
HETATM 4971 H H61  . HEX CA 4 .   ? 141.175 108.323 107.195 1.00 20.00  ? 410 HEX A H61  1 
HETATM 4972 H H62  . HEX CA 4 .   ? 142.841 108.693 106.732 1.00 20.00  ? 410 HEX A H62  1 
HETATM 4973 H H63  . HEX CA 4 .   ? 141.708 110.006 107.081 1.00 20.00  ? 410 HEX A H63  1 
HETATM 4974 C C1   . HEX DA 4 .   ? 144.422 129.387 115.661 1.00 20.00  ? 411 HEX A C1   1 
HETATM 4975 C C2   . HEX DA 4 .   ? 145.107 130.329 114.675 1.00 20.00  ? 411 HEX A C2   1 
HETATM 4976 C C3   . HEX DA 4 .   ? 144.840 129.941 113.223 1.00 20.00  ? 411 HEX A C3   1 
HETATM 4977 C C4   . HEX DA 4 .   ? 146.129 129.700 112.443 1.00 20.00  ? 411 HEX A C4   1 
HETATM 4978 C C5   . HEX DA 4 .   ? 145.864 129.334 110.985 1.00 20.00  ? 411 HEX A C5   1 
HETATM 4979 C C6   . HEX DA 4 .   ? 146.095 130.507 110.037 1.00 20.00  ? 411 HEX A C6   1 
HETATM 4980 H H11  . HEX DA 4 .   ? 144.567 129.753 116.670 1.00 20.00  ? 411 HEX A H11  1 
HETATM 4981 H H12  . HEX DA 4 .   ? 144.852 128.396 115.573 1.00 20.00  ? 411 HEX A H12  1 
HETATM 4982 H H13  . HEX DA 4 .   ? 143.362 129.341 115.442 1.00 20.00  ? 411 HEX A H13  1 
HETATM 4983 H H21  . HEX DA 4 .   ? 146.175 130.307 114.853 1.00 20.00  ? 411 HEX A H21  1 
HETATM 4984 H H22  . HEX DA 4 .   ? 144.743 131.335 114.842 1.00 20.00  ? 411 HEX A H22  1 
HETATM 4985 H H31  . HEX DA 4 .   ? 144.283 130.737 112.745 1.00 20.00  ? 411 HEX A H31  1 
HETATM 4986 H H32  . HEX DA 4 .   ? 144.245 129.036 113.206 1.00 20.00  ? 411 HEX A H32  1 
HETATM 4987 H H41  . HEX DA 4 .   ? 146.731 130.600 112.475 1.00 20.00  ? 411 HEX A H41  1 
HETATM 4988 H H42  . HEX DA 4 .   ? 146.678 128.894 112.913 1.00 20.00  ? 411 HEX A H42  1 
HETATM 4989 H H51  . HEX DA 4 .   ? 146.521 128.521 110.703 1.00 20.00  ? 411 HEX A H51  1 
HETATM 4990 H H52  . HEX DA 4 .   ? 144.836 129.004 110.890 1.00 20.00  ? 411 HEX A H52  1 
HETATM 4991 H H61  . HEX DA 4 .   ? 145.626 131.396 110.441 1.00 20.00  ? 411 HEX A H61  1 
HETATM 4992 H H62  . HEX DA 4 .   ? 145.664 130.279 109.070 1.00 20.00  ? 411 HEX A H62  1 
HETATM 4993 H H63  . HEX DA 4 .   ? 147.158 130.678 109.928 1.00 20.00  ? 411 HEX A H63  1 
HETATM 4994 C C1   . HEX EA 4 .   ? 132.806 99.450  135.865 1.00 20.00  ? 412 HEX A C1   1 
HETATM 4995 C C2   . HEX EA 4 .   ? 132.261 99.253  134.452 1.00 20.00  ? 412 HEX A C2   1 
HETATM 4996 C C3   . HEX EA 4 .   ? 130.741 99.384  134.392 1.00 20.00  ? 412 HEX A C3   1 
HETATM 4997 C C4   . HEX EA 4 .   ? 130.253 99.884  133.034 1.00 20.00  ? 412 HEX A C4   1 
HETATM 4998 C C5   . HEX EA 4 .   ? 128.756 100.183 133.032 1.00 20.00  ? 412 HEX A C5   1 
HETATM 4999 C C6   . HEX EA 4 .   ? 128.168 100.197 131.624 1.00 20.00  ? 412 HEX A C6   1 
HETATM 5000 H H11  . HEX EA 4 .   ? 132.483 100.410 136.247 1.00 20.00  ? 412 HEX A H11  1 
HETATM 5001 H H12  . HEX EA 4 .   ? 133.888 99.416  135.842 1.00 20.00  ? 412 HEX A H12  1 
HETATM 5002 H H13  . HEX EA 4 .   ? 132.434 98.661  136.508 1.00 20.00  ? 412 HEX A H13  1 
HETATM 5003 H H21  . HEX EA 4 .   ? 132.542 98.268  134.102 1.00 20.00  ? 412 HEX A H21  1 
HETATM 5004 H H22  . HEX EA 4 .   ? 132.703 99.997  133.801 1.00 20.00  ? 412 HEX A H22  1 
HETATM 5005 H H31  . HEX EA 4 .   ? 130.418 100.079 135.157 1.00 20.00  ? 412 HEX A H31  1 
HETATM 5006 H H32  . HEX EA 4 .   ? 130.298 98.416  134.589 1.00 20.00  ? 412 HEX A H32  1 
HETATM 5007 H H41  . HEX EA 4 .   ? 130.791 100.788 132.778 1.00 20.00  ? 412 HEX A H41  1 
HETATM 5008 H H42  . HEX EA 4 .   ? 130.460 99.128  132.287 1.00 20.00  ? 412 HEX A H42  1 
HETATM 5009 H H51  . HEX EA 4 .   ? 128.246 99.427  133.617 1.00 20.00  ? 412 HEX A H51  1 
HETATM 5010 H H52  . HEX EA 4 .   ? 128.592 101.151 133.490 1.00 20.00  ? 412 HEX A H52  1 
HETATM 5011 H H61  . HEX EA 4 .   ? 128.786 100.812 130.980 1.00 20.00  ? 412 HEX A H61  1 
HETATM 5012 H H62  . HEX EA 4 .   ? 127.165 100.602 131.655 1.00 20.00  ? 412 HEX A H62  1 
HETATM 5013 H H63  . HEX EA 4 .   ? 128.138 99.186  131.235 1.00 20.00  ? 412 HEX A H63  1 
HETATM 5014 C C1   . HEX FA 4 .   ? 142.641 132.808 118.671 1.00 20.00  ? 413 HEX A C1   1 
HETATM 5015 C C2   . HEX FA 4 .   ? 143.190 133.933 117.798 1.00 20.00  ? 413 HEX A C2   1 
HETATM 5016 C C3   . HEX FA 4 .   ? 142.226 134.326 116.682 1.00 20.00  ? 413 HEX A C3   1 
HETATM 5017 C C4   . HEX FA 4 .   ? 142.933 134.511 115.342 1.00 20.00  ? 413 HEX A C4   1 
HETATM 5018 C C5   . HEX FA 4 .   ? 142.145 135.411 114.394 1.00 20.00  ? 413 HEX A C5   1 
HETATM 5019 C C6   . HEX FA 4 .   ? 142.588 135.255 112.943 1.00 20.00  ? 413 HEX A C6   1 
HETATM 5020 H H11  . HEX FA 4 .   ? 143.312 132.637 119.503 1.00 20.00  ? 413 HEX A H11  1 
HETATM 5021 H H12  . HEX FA 4 .   ? 142.558 131.903 118.083 1.00 20.00  ? 413 HEX A H12  1 
HETATM 5022 H H13  . HEX FA 4 .   ? 141.664 133.086 119.046 1.00 20.00  ? 413 HEX A H13  1 
HETATM 5023 H H21  . HEX FA 4 .   ? 144.124 133.609 117.357 1.00 20.00  ? 413 HEX A H21  1 
HETATM 5024 H H22  . HEX FA 4 .   ? 143.377 134.800 118.420 1.00 20.00  ? 413 HEX A H22  1 
HETATM 5025 H H31  . HEX FA 4 .   ? 141.736 135.254 116.951 1.00 20.00  ? 413 HEX A H31  1 
HETATM 5026 H H32  . HEX FA 4 .   ? 141.475 133.552 116.578 1.00 20.00  ? 413 HEX A H32  1 
HETATM 5027 H H41  . HEX FA 4 .   ? 143.906 134.952 115.516 1.00 20.00  ? 413 HEX A H41  1 
HETATM 5028 H H42  . HEX FA 4 .   ? 143.065 133.541 114.877 1.00 20.00  ? 413 HEX A H42  1 
HETATM 5029 H H51  . HEX FA 4 .   ? 141.093 135.164 114.469 1.00 20.00  ? 413 HEX A H51  1 
HETATM 5030 H H52  . HEX FA 4 .   ? 142.285 136.442 114.694 1.00 20.00  ? 413 HEX A H52  1 
HETATM 5031 H H61  . HEX FA 4 .   ? 142.197 136.075 112.355 1.00 20.00  ? 413 HEX A H61  1 
HETATM 5032 H H62  . HEX FA 4 .   ? 142.211 134.318 112.550 1.00 20.00  ? 413 HEX A H62  1 
HETATM 5033 H H63  . HEX FA 4 .   ? 143.670 135.258 112.892 1.00 20.00  ? 413 HEX A H63  1 
HETATM 5034 C C1   . EIC GA 5 .   ? 114.316 104.566 109.428 1.00 20.00  ? 414 EIC A C1   1 
HETATM 5035 C C2   . EIC GA 5 .   ? 115.138 105.283 110.496 1.00 20.00  ? 414 EIC A C2   1 
HETATM 5036 C C3   . EIC GA 5 .   ? 114.336 106.083 111.545 1.00 20.00  ? 414 EIC A C3   1 
HETATM 5037 C C4   . EIC GA 5 .   ? 115.201 107.220 112.109 1.00 20.00  ? 414 EIC A C4   1 
HETATM 5038 C C5   . EIC GA 5 .   ? 115.171 107.286 113.639 1.00 20.00  ? 414 EIC A C5   1 
HETATM 5039 C C6   . EIC GA 5 .   ? 115.744 108.619 114.138 1.00 20.00  ? 414 EIC A C6   1 
HETATM 5040 C C7   . EIC GA 5 .   ? 116.281 108.508 115.573 1.00 20.00  ? 414 EIC A C7   1 
HETATM 5041 C C8   . EIC GA 5 .   ? 115.158 108.468 116.620 1.00 20.00  ? 414 EIC A C8   1 
HETATM 5042 C C9   . EIC GA 5 .   ? 115.310 109.606 117.605 1.00 20.00  ? 414 EIC A C9   1 
HETATM 5043 C C10  . EIC GA 5 .   ? 114.572 109.869 118.686 1.00 20.00  ? 414 EIC A C10  1 
HETATM 5044 C C11  . EIC GA 5 .   ? 113.393 109.100 119.232 1.00 20.00  ? 414 EIC A C11  1 
HETATM 5045 C C12  . EIC GA 5 .   ? 113.300 109.328 120.726 1.00 20.00  ? 414 EIC A C12  1 
HETATM 5046 C C13  . EIC GA 5 .   ? 112.763 108.531 121.656 1.00 20.00  ? 414 EIC A C13  1 
HETATM 5047 C C14  . EIC GA 5 .   ? 112.102 107.188 121.450 1.00 20.00  ? 414 EIC A C14  1 
HETATM 5048 C C15  . EIC GA 5 .   ? 112.051 106.410 122.771 1.00 20.00  ? 414 EIC A C15  1 
HETATM 5049 C C16  . EIC GA 5 .   ? 111.384 105.041 122.583 1.00 20.00  ? 414 EIC A C16  1 
HETATM 5050 C C17  . EIC GA 5 .   ? 112.400 103.906 122.749 1.00 20.00  ? 414 EIC A C17  1 
HETATM 5051 C C18  . EIC GA 5 .   ? 111.835 102.565 122.274 1.00 20.00  ? 414 EIC A C18  1 
HETATM 5052 O O1   . EIC GA 5 .   ? 113.140 104.364 109.622 1.00 20.00  ? 414 EIC A O1   1 
HETATM 5053 O O2   . EIC GA 5 .   ? 114.898 104.234 108.423 1.00 20.00  ? 414 EIC A O2   1 
HETATM 5054 H H21  . EIC GA 5 .   ? 115.750 104.529 111.007 1.00 20.00  ? 414 EIC A H21  1 
HETATM 5055 H H22  . EIC GA 5 .   ? 115.830 105.960 109.978 1.00 20.00  ? 414 EIC A H22  1 
HETATM 5056 H H31  . EIC GA 5 .   ? 114.016 105.413 112.353 1.00 20.00  ? 414 EIC A H31  1 
HETATM 5057 H H32  . EIC GA 5 .   ? 113.433 106.505 111.085 1.00 20.00  ? 414 EIC A H32  1 
HETATM 5058 H H41  . EIC GA 5 .   ? 114.839 108.174 111.709 1.00 20.00  ? 414 EIC A H41  1 
HETATM 5059 H H42  . EIC GA 5 .   ? 116.236 107.097 111.766 1.00 20.00  ? 414 EIC A H42  1 
HETATM 5060 H H51  . EIC GA 5 .   ? 115.748 106.449 114.050 1.00 20.00  ? 414 EIC A H51  1 
HETATM 5061 H H52  . EIC GA 5 .   ? 114.137 107.180 113.987 1.00 20.00  ? 414 EIC A H52  1 
HETATM 5062 H H61  . EIC GA 5 .   ? 114.963 109.389 114.094 1.00 20.00  ? 414 EIC A H61  1 
HETATM 5063 H H62  . EIC GA 5 .   ? 116.555 108.936 113.469 1.00 20.00  ? 414 EIC A H62  1 
HETATM 5064 H H71  . EIC GA 5 .   ? 116.943 109.360 115.765 1.00 20.00  ? 414 EIC A H71  1 
HETATM 5065 H H72  . EIC GA 5 .   ? 116.885 107.595 115.665 1.00 20.00  ? 414 EIC A H72  1 
HETATM 5066 H H81  . EIC GA 5 .   ? 114.191 108.556 116.113 1.00 20.00  ? 414 EIC A H81  1 
HETATM 5067 H H82  . EIC GA 5 .   ? 115.162 107.492 117.114 1.00 20.00  ? 414 EIC A H82  1 
HETATM 5068 H H91  . EIC GA 5 .   ? 116.128 110.286 117.373 1.00 20.00  ? 414 EIC A H91  1 
HETATM 5069 H H1O1 . EIC GA 5 .   ? 114.829 110.744 119.284 1.00 20.00  ? 414 EIC A H1O1 1 
HETATM 5070 H H111 . EIC GA 5 .   ? 113.493 108.026 119.045 1.00 20.00  ? 414 EIC A H111 1 
HETATM 5071 H H112 . EIC GA 5 .   ? 112.490 109.432 118.709 1.00 20.00  ? 414 EIC A H112 1 
HETATM 5072 H H121 . EIC GA 5 .   ? 113.738 110.272 121.048 1.00 20.00  ? 414 EIC A H121 1 
HETATM 5073 H H131 . EIC GA 5 .   ? 112.782 108.854 122.695 1.00 20.00  ? 414 EIC A H131 1 
HETATM 5074 H H141 . EIC GA 5 .   ? 111.087 107.287 121.053 1.00 20.00  ? 414 EIC A H141 1 
HETATM 5075 H H142 . EIC GA 5 .   ? 112.674 106.608 120.715 1.00 20.00  ? 414 EIC A H142 1 
HETATM 5076 H H151 . EIC GA 5 .   ? 111.504 106.998 123.518 1.00 20.00  ? 414 EIC A H151 1 
HETATM 5077 H H152 . EIC GA 5 .   ? 113.073 106.264 123.146 1.00 20.00  ? 414 EIC A H152 1 
HETATM 5078 H H161 . EIC GA 5 .   ? 110.945 104.988 121.577 1.00 20.00  ? 414 EIC A H161 1 
HETATM 5079 H H162 . EIC GA 5 .   ? 110.567 104.919 123.308 1.00 20.00  ? 414 EIC A H162 1 
HETATM 5080 H H171 . EIC GA 5 .   ? 112.694 103.828 123.803 1.00 20.00  ? 414 EIC A H171 1 
HETATM 5081 H H172 . EIC GA 5 .   ? 113.304 104.136 122.175 1.00 20.00  ? 414 EIC A H172 1 
HETATM 5082 H H181 . EIC GA 5 .   ? 111.725 102.565 121.184 1.00 20.00  ? 414 EIC A H181 1 
HETATM 5083 H H182 . EIC GA 5 .   ? 112.497 101.738 122.558 1.00 20.00  ? 414 EIC A H182 1 
HETATM 5084 H H183 . EIC GA 5 .   ? 110.845 102.383 122.715 1.00 20.00  ? 414 EIC A H183 1 
HETATM 5085 C C27  . R16 HA 6 .   ? 136.118 127.047 124.894 1.00 20.00  ? 415 R16 A C27  1 
HETATM 5086 C C28  . R16 HA 6 .   ? 136.328 126.902 126.386 1.00 20.00  ? 415 R16 A C28  1 
HETATM 5087 C C29  . R16 HA 6 .   ? 137.760 126.506 126.714 1.00 20.00  ? 415 R16 A C29  1 
HETATM 5088 C C30  . R16 HA 6 .   ? 137.856 125.827 128.081 1.00 20.00  ? 415 R16 A C30  1 
HETATM 5089 C C31  . R16 HA 6 .   ? 139.072 126.286 128.887 1.00 20.00  ? 415 R16 A C31  1 
HETATM 5090 C C32  . R16 HA 6 .   ? 139.722 125.131 129.653 1.00 20.00  ? 415 R16 A C32  1 
HETATM 5091 C C33  . R16 HA 6 .   ? 140.558 125.631 130.833 1.00 20.00  ? 415 R16 A C33  1 
HETATM 5092 C C34  . R16 HA 6 .   ? 141.627 124.619 131.253 1.00 20.00  ? 415 R16 A C34  1 
HETATM 5093 C C35  . R16 HA 6 .   ? 141.914 124.646 132.756 1.00 20.00  ? 415 R16 A C35  1 
HETATM 5094 C C36  . R16 HA 6 .   ? 142.333 123.261 133.252 1.00 20.00  ? 415 R16 A C36  1 
HETATM 5095 C C37  . R16 HA 6 .   ? 142.557 123.205 134.761 1.00 20.00  ? 415 R16 A C37  1 
HETATM 5096 C C38  . R16 HA 6 .   ? 141.235 123.156 135.523 1.00 20.00  ? 415 R16 A C38  1 
HETATM 5097 C C39  . R16 HA 6 .   ? 141.010 121.830 136.219 1.00 20.00  ? 415 R16 A C39  1 
HETATM 5098 C C40  . R16 HA 6 .   ? 141.312 121.925 137.690 1.00 20.00  ? 415 R16 A C40  1 
HETATM 5099 C C41  . R16 HA 6 .   ? 142.803 122.008 137.911 1.00 20.00  ? 415 R16 A C41  1 
HETATM 5100 C C42  . R16 HA 6 .   ? 143.166 121.527 139.292 1.00 20.00  ? 415 R16 A C42  1 
HETATM 5101 H H271 . R16 HA 6 .   ? 135.509 127.923 124.634 1.00 20.00  ? 415 R16 A H271 1 
HETATM 5102 H H272 . R16 HA 6 .   ? 137.065 127.144 124.350 1.00 20.00  ? 415 R16 A H272 1 
HETATM 5103 H H273 . R16 HA 6 .   ? 135.603 126.180 124.462 1.00 20.00  ? 415 R16 A H273 1 
HETATM 5104 H H281 . R16 HA 6 .   ? 135.621 126.152 126.791 1.00 20.00  ? 415 R16 A H281 1 
HETATM 5105 H H282 . R16 HA 6 .   ? 136.056 127.843 126.904 1.00 20.00  ? 415 R16 A H282 1 
HETATM 5106 H H291 . R16 HA 6 .   ? 138.149 125.836 125.922 1.00 20.00  ? 415 R16 A H291 1 
HETATM 5107 H H292 . R16 HA 6 .   ? 138.416 127.395 126.669 1.00 20.00  ? 415 R16 A H292 1 
HETATM 5108 H H301 . R16 HA 6 .   ? 136.927 126.016 128.654 1.00 20.00  ? 415 R16 A H301 1 
HETATM 5109 H H302 . R16 HA 6 .   ? 137.884 124.726 127.956 1.00 20.00  ? 415 R16 A H302 1 
HETATM 5110 H H311 . R16 HA 6 .   ? 139.817 126.761 128.221 1.00 20.00  ? 415 R16 A H311 1 
HETATM 5111 H H312 . R16 HA 6 .   ? 138.779 127.092 129.591 1.00 20.00  ? 415 R16 A H312 1 
HETATM 5112 H H321 . R16 HA 6 .   ? 140.348 124.527 128.965 1.00 20.00  ? 415 R16 A H321 1 
HETATM 5113 H H322 . R16 HA 6 .   ? 138.948 124.423 130.010 1.00 20.00  ? 415 R16 A H322 1 
HETATM 5114 H H331 . R16 HA 6 .   ? 141.026 126.602 130.574 1.00 20.00  ? 415 R16 A H331 1 
HETATM 5115 H H332 . R16 HA 6 .   ? 139.898 125.865 131.692 1.00 20.00  ? 415 R16 A H332 1 
HETATM 5116 H H341 . R16 HA 6 .   ? 142.560 124.804 130.686 1.00 20.00  ? 415 R16 A H341 1 
HETATM 5117 H H342 . R16 HA 6 .   ? 141.320 123.599 130.949 1.00 20.00  ? 415 R16 A H342 1 
HETATM 5118 H H351 . R16 HA 6 .   ? 142.703 125.388 132.988 1.00 20.00  ? 415 R16 A H351 1 
HETATM 5119 H H352 . R16 HA 6 .   ? 141.024 125.004 133.312 1.00 20.00  ? 415 R16 A H352 1 
HETATM 5120 H H361 . R16 HA 6 .   ? 143.249 122.938 132.723 1.00 20.00  ? 415 R16 A H361 1 
HETATM 5121 H H362 . R16 HA 6 .   ? 141.570 122.513 132.962 1.00 20.00  ? 415 R16 A H362 1 
HETATM 5122 H H371 . R16 HA 6 .   ? 143.150 124.077 135.094 1.00 20.00  ? 415 R16 A H371 1 
HETATM 5123 H H372 . R16 HA 6 .   ? 143.183 122.332 135.022 1.00 20.00  ? 415 R16 A H372 1 
HETATM 5124 H H381 . R16 HA 6 .   ? 140.394 123.369 134.838 1.00 20.00  ? 415 R16 A H381 1 
HETATM 5125 H H382 . R16 HA 6 .   ? 141.197 123.981 136.261 1.00 20.00  ? 415 R16 A H382 1 
HETATM 5126 H H391 . R16 HA 6 .   ? 139.966 121.496 136.068 1.00 20.00  ? 415 R16 A H391 1 
HETATM 5127 H H392 . R16 HA 6 .   ? 141.628 121.039 135.754 1.00 20.00  ? 415 R16 A H392 1 
HETATM 5128 H H401 . R16 HA 6 .   ? 140.811 122.808 138.134 1.00 20.00  ? 415 R16 A H401 1 
HETATM 5129 H H402 . R16 HA 6 .   ? 140.894 121.058 138.236 1.00 20.00  ? 415 R16 A H402 1 
HETATM 5130 H H411 . R16 HA 6 .   ? 143.344 121.426 137.142 1.00 20.00  ? 415 R16 A H411 1 
HETATM 5131 H H412 . R16 HA 6 .   ? 143.137 123.058 137.773 1.00 20.00  ? 415 R16 A H412 1 
HETATM 5132 H H421 . R16 HA 6 .   ? 142.723 120.550 139.516 1.00 20.00  ? 415 R16 A H421 1 
HETATM 5133 H H422 . R16 HA 6 .   ? 144.246 121.406 139.428 1.00 20.00  ? 415 R16 A H422 1 
HETATM 5134 H H423 . R16 HA 6 .   ? 142.816 122.210 140.078 1.00 20.00  ? 415 R16 A H423 1 
HETATM 5135 K K    . K   IA 7 .   ? 120.232 120.253 117.113 1.00 52.23  ? 416 K   A K    1 
HETATM 5136 K K    . K   JA 7 .   ? 120.227 120.253 108.033 1.00 60.30  ? 417 K   A K    1 
HETATM 5137 K K    . K   KA 7 .   ? 120.229 120.252 111.366 1.00 30.00  ? 418 K   A K    1 
HETATM 5138 K K    . K   LA 7 .   ? 120.186 120.285 114.327 1.00 30.00  ? 419 K   A K    1 
# 
