data_9BZL
# 
_entry.id   9BZL 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.402 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9BZL         pdb_00009bzl 10.2210/pdb9bzl/pdb 
WWPDB D_1000284452 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-01-15 ? 
2 'Structure model' 1 1 2025-01-22 ? 
3 'Structure model' 1 2 2025-03-05 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_CSD'          
4  2 'Structure model' '_citation.journal_id_ISSN'         
5  2 'Structure model' '_citation.pdbx_database_id_DOI'    
6  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
7  2 'Structure model' '_citation.title'                   
8  2 'Structure model' '_citation.year'                    
9  2 'Structure model' '_citation_author.name'             
10 3 'Structure model' '_citation.journal_volume'          
11 3 'Structure model' '_citation.page_first'              
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9BZL 
_pdbx_database_status.recvd_initial_deposition_date   2024-05-24 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
loop_
_pdbx_contact_author.id 
_pdbx_contact_author.email 
_pdbx_contact_author.name_first 
_pdbx_contact_author.name_last 
_pdbx_contact_author.name_mi 
_pdbx_contact_author.role 
_pdbx_contact_author.identifier_ORCID 
3 daharki@umn.edu  Daniel   Harki    D 'principal investigator/group leader' 0000-0001-5950-931X 
4 nml@umn.edu      Nicholas Levinson M 'principal investigator/group leader' 0000-0003-4338-8087 
5 aihar001@umn.edu Hideki   Aihara   ? 'principal investigator/group leader' 0000-0001-7508-6230 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Baker, Z.D.'    1 0000-0001-7732-9566 
'Tang, J.'       2 0000-0002-7611-7390 
'Shi, K.'        3 0000-0001-9458-5019 
'Aihara, H.'     4 0000-0001-7508-6230 
'Levinson, N.M.' 5 0000-0003-4338-8087 
'Harki, D.A.'    6 0000-0001-5950-931X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Cell Chem Biol' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2451-9456 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            32 
_citation.language                  ? 
_citation.page_first                352 
_citation.page_last                 ? 
_citation.title                     'Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.chembiol.2024.12.006 
_citation.pdbx_database_id_PubMed   39778578 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Tang, J.'       1  ? 
primary 'Moorthy, R.'    2  ? 
primary 'Hirsch, L.E.'   3  ? 
primary 'Demir, O.'      4  ? 
primary 'Baker, Z.D.'    5  ? 
primary 'Naumann, J.A.'  6  ? 
primary 'Jones, K.F.M.'  7  ? 
primary 'Grillo, M.J.'   8  ? 
primary 'Haefner, E.S.'  9  ? 
primary 'Shi, K.'        10 ? 
primary 'Levy, M.J.'     11 ? 
primary 'Gupta, H.B.'    12 ? 
primary 'Aihara, H.'     13 ? 
primary 'Harris, R.S.'   14 ? 
primary 'Amaro, R.E.'    15 ? 
primary 'Levinson, N.M.' 16 ? 
primary 'Harki, D.A.'    17 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Aurora kinase A' 32980.637 1   2.7.11.1 'C290A, C393S' ? ? 
2 non-polymer syn 
'7-cyclopentyl-N,N-dimethyl-2-{[5-(methylcarbamoyl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide' 407.469   1   ? 
?              ? ? 
3 water       nat water 18.015    118 ?        ?              ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        
;Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A
;
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   yes 
_entity_poly.pdbx_seq_one_letter_code       
;GAMESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG
YFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS
VHAPSSRRT(TPO)LAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTE
GARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNSQNKESASKQS
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GAMESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG
YFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS
VHAPSSRRTTLAGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARD
LISRLLKHNPSQRPMLREVLEHPWITANSSKPSNSQNKESASKQS
;
_entity_poly.pdbx_strand_id                 B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 '7-cyclopentyl-N,N-dimethyl-2-{[5-(methylcarbamoyl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide' OGR 
3 water                                                                                                             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   ALA n 
1 3   MET n 
1 4   GLU n 
1 5   SER n 
1 6   LYS n 
1 7   LYS n 
1 8   ARG n 
1 9   GLN n 
1 10  TRP n 
1 11  ALA n 
1 12  LEU n 
1 13  GLU n 
1 14  ASP n 
1 15  PHE n 
1 16  GLU n 
1 17  ILE n 
1 18  GLY n 
1 19  ARG n 
1 20  PRO n 
1 21  LEU n 
1 22  GLY n 
1 23  LYS n 
1 24  GLY n 
1 25  LYS n 
1 26  PHE n 
1 27  GLY n 
1 28  ASN n 
1 29  VAL n 
1 30  TYR n 
1 31  LEU n 
1 32  ALA n 
1 33  ARG n 
1 34  GLU n 
1 35  LYS n 
1 36  GLN n 
1 37  SER n 
1 38  LYS n 
1 39  PHE n 
1 40  ILE n 
1 41  LEU n 
1 42  ALA n 
1 43  LEU n 
1 44  LYS n 
1 45  VAL n 
1 46  LEU n 
1 47  PHE n 
1 48  LYS n 
1 49  ALA n 
1 50  GLN n 
1 51  LEU n 
1 52  GLU n 
1 53  LYS n 
1 54  ALA n 
1 55  GLY n 
1 56  VAL n 
1 57  GLU n 
1 58  HIS n 
1 59  GLN n 
1 60  LEU n 
1 61  ARG n 
1 62  ARG n 
1 63  GLU n 
1 64  VAL n 
1 65  GLU n 
1 66  ILE n 
1 67  GLN n 
1 68  SER n 
1 69  HIS n 
1 70  LEU n 
1 71  ARG n 
1 72  HIS n 
1 73  PRO n 
1 74  ASN n 
1 75  ILE n 
1 76  LEU n 
1 77  ARG n 
1 78  LEU n 
1 79  TYR n 
1 80  GLY n 
1 81  TYR n 
1 82  PHE n 
1 83  HIS n 
1 84  ASP n 
1 85  ALA n 
1 86  THR n 
1 87  ARG n 
1 88  VAL n 
1 89  TYR n 
1 90  LEU n 
1 91  ILE n 
1 92  LEU n 
1 93  GLU n 
1 94  TYR n 
1 95  ALA n 
1 96  PRO n 
1 97  LEU n 
1 98  GLY n 
1 99  THR n 
1 100 VAL n 
1 101 TYR n 
1 102 ARG n 
1 103 GLU n 
1 104 LEU n 
1 105 GLN n 
1 106 LYS n 
1 107 LEU n 
1 108 SER n 
1 109 LYS n 
1 110 PHE n 
1 111 ASP n 
1 112 GLU n 
1 113 GLN n 
1 114 ARG n 
1 115 THR n 
1 116 ALA n 
1 117 THR n 
1 118 TYR n 
1 119 ILE n 
1 120 THR n 
1 121 GLU n 
1 122 LEU n 
1 123 ALA n 
1 124 ASN n 
1 125 ALA n 
1 126 LEU n 
1 127 SER n 
1 128 TYR n 
1 129 CYS n 
1 130 HIS n 
1 131 SER n 
1 132 LYS n 
1 133 ARG n 
1 134 VAL n 
1 135 ILE n 
1 136 HIS n 
1 137 ARG n 
1 138 ASP n 
1 139 ILE n 
1 140 LYS n 
1 141 PRO n 
1 142 GLU n 
1 143 ASN n 
1 144 LEU n 
1 145 LEU n 
1 146 LEU n 
1 147 GLY n 
1 148 SER n 
1 149 ALA n 
1 150 GLY n 
1 151 GLU n 
1 152 LEU n 
1 153 LYS n 
1 154 ILE n 
1 155 ALA n 
1 156 ASP n 
1 157 PHE n 
1 158 GLY n 
1 159 TRP n 
1 160 SER n 
1 161 VAL n 
1 162 HIS n 
1 163 ALA n 
1 164 PRO n 
1 165 SER n 
1 166 SER n 
1 167 ARG n 
1 168 ARG n 
1 169 THR n 
1 170 TPO n 
1 171 LEU n 
1 172 ALA n 
1 173 GLY n 
1 174 THR n 
1 175 LEU n 
1 176 ASP n 
1 177 TYR n 
1 178 LEU n 
1 179 PRO n 
1 180 PRO n 
1 181 GLU n 
1 182 MET n 
1 183 ILE n 
1 184 GLU n 
1 185 GLY n 
1 186 ARG n 
1 187 MET n 
1 188 HIS n 
1 189 ASP n 
1 190 GLU n 
1 191 LYS n 
1 192 VAL n 
1 193 ASP n 
1 194 LEU n 
1 195 TRP n 
1 196 SER n 
1 197 LEU n 
1 198 GLY n 
1 199 VAL n 
1 200 LEU n 
1 201 CYS n 
1 202 TYR n 
1 203 GLU n 
1 204 PHE n 
1 205 LEU n 
1 206 VAL n 
1 207 GLY n 
1 208 LYS n 
1 209 PRO n 
1 210 PRO n 
1 211 PHE n 
1 212 GLU n 
1 213 ALA n 
1 214 ASN n 
1 215 THR n 
1 216 TYR n 
1 217 GLN n 
1 218 GLU n 
1 219 THR n 
1 220 TYR n 
1 221 LYS n 
1 222 ARG n 
1 223 ILE n 
1 224 SER n 
1 225 ARG n 
1 226 VAL n 
1 227 GLU n 
1 228 PHE n 
1 229 THR n 
1 230 PHE n 
1 231 PRO n 
1 232 ASP n 
1 233 PHE n 
1 234 VAL n 
1 235 THR n 
1 236 GLU n 
1 237 GLY n 
1 238 ALA n 
1 239 ARG n 
1 240 ASP n 
1 241 LEU n 
1 242 ILE n 
1 243 SER n 
1 244 ARG n 
1 245 LEU n 
1 246 LEU n 
1 247 LYS n 
1 248 HIS n 
1 249 ASN n 
1 250 PRO n 
1 251 SER n 
1 252 GLN n 
1 253 ARG n 
1 254 PRO n 
1 255 MET n 
1 256 LEU n 
1 257 ARG n 
1 258 GLU n 
1 259 VAL n 
1 260 LEU n 
1 261 GLU n 
1 262 HIS n 
1 263 PRO n 
1 264 TRP n 
1 265 ILE n 
1 266 THR n 
1 267 ALA n 
1 268 ASN n 
1 269 SER n 
1 270 SER n 
1 271 LYS n 
1 272 PRO n 
1 273 SER n 
1 274 ASN n 
1 275 SER n 
1 276 GLN n 
1 277 ASN n 
1 278 LYS n 
1 279 GLU n 
1 280 SER n 
1 281 ALA n 
1 282 SER n 
1 283 LYS n 
1 284 GLN n 
1 285 SER n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   285 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli BL21(DE3)' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     469008 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              -RIL 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?                  'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ?                  'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                  'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                  'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE ?                  'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ?                  'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                  'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE ?                  'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ?                  'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER ?                  'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE ?                  'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ?                  'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ?                  'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ?                  'C5 H11 N O2 S'  149.211 
OGR non-polymer         . 
'7-cyclopentyl-N,N-dimethyl-2-{[5-(methylcarbamoyl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide' ? 
'C21 H25 N7 O2'  407.469 
PHE 'L-peptide linking' y PHENYLALANINE ?                  'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE ?                  'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ?                  'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ?                  'C4 H9 N O3'     119.119 
TPO 'L-peptide linking' n PHOSPHOTHREONINE PHOSPHONOTHREONINE 'C4 H10 N O6 P'  199.099 
TRP 'L-peptide linking' y TRYPTOPHAN ?                  'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ?                  'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ?                  'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   119 ?   ?   ?   B . n 
A 1 2   ALA 2   120 ?   ?   ?   B . n 
A 1 3   MET 3   121 ?   ?   ?   B . n 
A 1 4   GLU 4   122 ?   ?   ?   B . n 
A 1 5   SER 5   123 ?   ?   ?   B . n 
A 1 6   LYS 6   124 ?   ?   ?   B . n 
A 1 7   LYS 7   125 ?   ?   ?   B . n 
A 1 8   ARG 8   126 ?   ?   ?   B . n 
A 1 9   GLN 9   127 127 GLN GLN B . n 
A 1 10  TRP 10  128 128 TRP TRP B . n 
A 1 11  ALA 11  129 129 ALA ALA B . n 
A 1 12  LEU 12  130 130 LEU LEU B . n 
A 1 13  GLU 13  131 131 GLU GLU B . n 
A 1 14  ASP 14  132 132 ASP ASP B . n 
A 1 15  PHE 15  133 133 PHE PHE B . n 
A 1 16  GLU 16  134 134 GLU GLU B . n 
A 1 17  ILE 17  135 135 ILE ILE B . n 
A 1 18  GLY 18  136 136 GLY GLY B . n 
A 1 19  ARG 19  137 137 ARG ARG B . n 
A 1 20  PRO 20  138 138 PRO PRO B . n 
A 1 21  LEU 21  139 139 LEU LEU B . n 
A 1 22  GLY 22  140 140 GLY GLY B . n 
A 1 23  LYS 23  141 141 LYS LYS B . n 
A 1 24  GLY 24  142 142 GLY GLY B . n 
A 1 25  LYS 25  143 143 LYS LYS B . n 
A 1 26  PHE 26  144 144 PHE PHE B . n 
A 1 27  GLY 27  145 145 GLY GLY B . n 
A 1 28  ASN 28  146 146 ASN ASN B . n 
A 1 29  VAL 29  147 147 VAL VAL B . n 
A 1 30  TYR 30  148 148 TYR TYR B . n 
A 1 31  LEU 31  149 149 LEU LEU B . n 
A 1 32  ALA 32  150 150 ALA ALA B . n 
A 1 33  ARG 33  151 151 ARG ARG B . n 
A 1 34  GLU 34  152 152 GLU GLU B . n 
A 1 35  LYS 35  153 153 LYS LYS B . n 
A 1 36  GLN 36  154 154 GLN GLN B . n 
A 1 37  SER 37  155 155 SER SER B . n 
A 1 38  LYS 38  156 156 LYS LYS B . n 
A 1 39  PHE 39  157 157 PHE PHE B . n 
A 1 40  ILE 40  158 158 ILE ILE B . n 
A 1 41  LEU 41  159 159 LEU LEU B . n 
A 1 42  ALA 42  160 160 ALA ALA B . n 
A 1 43  LEU 43  161 161 LEU LEU B . n 
A 1 44  LYS 44  162 162 LYS LYS B . n 
A 1 45  VAL 45  163 163 VAL VAL B . n 
A 1 46  LEU 46  164 164 LEU LEU B . n 
A 1 47  PHE 47  165 165 PHE PHE B . n 
A 1 48  LYS 48  166 166 LYS LYS B . n 
A 1 49  ALA 49  167 167 ALA ALA B . n 
A 1 50  GLN 50  168 168 GLN GLN B . n 
A 1 51  LEU 51  169 169 LEU LEU B . n 
A 1 52  GLU 52  170 170 GLU GLU B . n 
A 1 53  LYS 53  171 171 LYS LYS B . n 
A 1 54  ALA 54  172 172 ALA ALA B . n 
A 1 55  GLY 55  173 173 GLY GLY B . n 
A 1 56  VAL 56  174 174 VAL VAL B . n 
A 1 57  GLU 57  175 175 GLU GLU B . n 
A 1 58  HIS 58  176 176 HIS HIS B . n 
A 1 59  GLN 59  177 177 GLN GLN B . n 
A 1 60  LEU 60  178 178 LEU LEU B . n 
A 1 61  ARG 61  179 179 ARG ARG B . n 
A 1 62  ARG 62  180 180 ARG ARG B . n 
A 1 63  GLU 63  181 181 GLU GLU B . n 
A 1 64  VAL 64  182 182 VAL VAL B . n 
A 1 65  GLU 65  183 183 GLU GLU B . n 
A 1 66  ILE 66  184 184 ILE ILE B . n 
A 1 67  GLN 67  185 185 GLN GLN B . n 
A 1 68  SER 68  186 186 SER SER B . n 
A 1 69  HIS 69  187 187 HIS HIS B . n 
A 1 70  LEU 70  188 188 LEU LEU B . n 
A 1 71  ARG 71  189 189 ARG ARG B . n 
A 1 72  HIS 72  190 190 HIS HIS B . n 
A 1 73  PRO 73  191 191 PRO PRO B . n 
A 1 74  ASN 74  192 192 ASN ASN B . n 
A 1 75  ILE 75  193 193 ILE ILE B . n 
A 1 76  LEU 76  194 194 LEU LEU B . n 
A 1 77  ARG 77  195 195 ARG ARG B . n 
A 1 78  LEU 78  196 196 LEU LEU B . n 
A 1 79  TYR 79  197 197 TYR TYR B . n 
A 1 80  GLY 80  198 198 GLY GLY B . n 
A 1 81  TYR 81  199 199 TYR TYR B . n 
A 1 82  PHE 82  200 200 PHE PHE B . n 
A 1 83  HIS 83  201 201 HIS HIS B . n 
A 1 84  ASP 84  202 202 ASP ASP B . n 
A 1 85  ALA 85  203 203 ALA ALA B . n 
A 1 86  THR 86  204 204 THR THR B . n 
A 1 87  ARG 87  205 205 ARG ARG B . n 
A 1 88  VAL 88  206 206 VAL VAL B . n 
A 1 89  TYR 89  207 207 TYR TYR B . n 
A 1 90  LEU 90  208 208 LEU LEU B . n 
A 1 91  ILE 91  209 209 ILE ILE B . n 
A 1 92  LEU 92  210 210 LEU LEU B . n 
A 1 93  GLU 93  211 211 GLU GLU B . n 
A 1 94  TYR 94  212 212 TYR TYR B . n 
A 1 95  ALA 95  213 213 ALA ALA B . n 
A 1 96  PRO 96  214 214 PRO PRO B . n 
A 1 97  LEU 97  215 215 LEU LEU B . n 
A 1 98  GLY 98  216 216 GLY GLY B . n 
A 1 99  THR 99  217 217 THR THR B . n 
A 1 100 VAL 100 218 218 VAL VAL B . n 
A 1 101 TYR 101 219 219 TYR TYR B . n 
A 1 102 ARG 102 220 220 ARG ARG B . n 
A 1 103 GLU 103 221 221 GLU GLU B . n 
A 1 104 LEU 104 222 222 LEU LEU B . n 
A 1 105 GLN 105 223 223 GLN GLN B . n 
A 1 106 LYS 106 224 224 LYS LYS B . n 
A 1 107 LEU 107 225 225 LEU LEU B . n 
A 1 108 SER 108 226 226 SER SER B . n 
A 1 109 LYS 109 227 227 LYS LYS B . n 
A 1 110 PHE 110 228 228 PHE PHE B . n 
A 1 111 ASP 111 229 229 ASP ASP B . n 
A 1 112 GLU 112 230 230 GLU GLU B . n 
A 1 113 GLN 113 231 231 GLN GLN B . n 
A 1 114 ARG 114 232 232 ARG ARG B . n 
A 1 115 THR 115 233 233 THR THR B . n 
A 1 116 ALA 116 234 234 ALA ALA B . n 
A 1 117 THR 117 235 235 THR THR B . n 
A 1 118 TYR 118 236 236 TYR TYR B . n 
A 1 119 ILE 119 237 237 ILE ILE B . n 
A 1 120 THR 120 238 238 THR THR B . n 
A 1 121 GLU 121 239 239 GLU GLU B . n 
A 1 122 LEU 122 240 240 LEU LEU B . n 
A 1 123 ALA 123 241 241 ALA ALA B . n 
A 1 124 ASN 124 242 242 ASN ASN B . n 
A 1 125 ALA 125 243 243 ALA ALA B . n 
A 1 126 LEU 126 244 244 LEU LEU B . n 
A 1 127 SER 127 245 245 SER SER B . n 
A 1 128 TYR 128 246 246 TYR TYR B . n 
A 1 129 CYS 129 247 247 CYS CYS B . n 
A 1 130 HIS 130 248 248 HIS HIS B . n 
A 1 131 SER 131 249 249 SER SER B . n 
A 1 132 LYS 132 250 250 LYS LYS B . n 
A 1 133 ARG 133 251 251 ARG ARG B . n 
A 1 134 VAL 134 252 252 VAL VAL B . n 
A 1 135 ILE 135 253 253 ILE ILE B . n 
A 1 136 HIS 136 254 254 HIS HIS B . n 
A 1 137 ARG 137 255 255 ARG ARG B . n 
A 1 138 ASP 138 256 256 ASP ASP B . n 
A 1 139 ILE 139 257 257 ILE ILE B . n 
A 1 140 LYS 140 258 258 LYS LYS B . n 
A 1 141 PRO 141 259 259 PRO PRO B . n 
A 1 142 GLU 142 260 260 GLU GLU B . n 
A 1 143 ASN 143 261 261 ASN ASN B . n 
A 1 144 LEU 144 262 262 LEU LEU B . n 
A 1 145 LEU 145 263 263 LEU LEU B . n 
A 1 146 LEU 146 264 264 LEU LEU B . n 
A 1 147 GLY 147 265 265 GLY GLY B . n 
A 1 148 SER 148 266 266 SER SER B . n 
A 1 149 ALA 149 267 267 ALA ALA B . n 
A 1 150 GLY 150 268 268 GLY GLY B . n 
A 1 151 GLU 151 269 269 GLU GLU B . n 
A 1 152 LEU 152 270 270 LEU LEU B . n 
A 1 153 LYS 153 271 271 LYS LYS B . n 
A 1 154 ILE 154 272 272 ILE ILE B . n 
A 1 155 ALA 155 273 273 ALA ALA B . n 
A 1 156 ASP 156 274 274 ASP ASP B . n 
A 1 157 PHE 157 275 275 PHE PHE B . n 
A 1 158 GLY 158 276 276 GLY GLY B . n 
A 1 159 TRP 159 277 277 TRP TRP B . n 
A 1 160 SER 160 278 278 SER SER B . n 
A 1 161 VAL 161 279 279 VAL VAL B . n 
A 1 162 HIS 162 280 280 HIS HIS B . n 
A 1 163 ALA 163 281 281 ALA ALA B . n 
A 1 164 PRO 164 282 282 PRO PRO B . n 
A 1 165 SER 165 283 283 SER SER B . n 
A 1 166 SER 166 284 284 SER SER B . n 
A 1 167 ARG 167 285 285 ARG ARG B . n 
A 1 168 ARG 168 286 286 ARG ARG B . n 
A 1 169 THR 169 287 287 THR THR B . n 
A 1 170 TPO 170 288 288 TPO TPO B . n 
A 1 171 LEU 171 289 289 LEU LEU B . n 
A 1 172 ALA 172 290 290 ALA ALA B . n 
A 1 173 GLY 173 291 291 GLY GLY B . n 
A 1 174 THR 174 292 292 THR THR B . n 
A 1 175 LEU 175 293 293 LEU LEU B . n 
A 1 176 ASP 176 294 294 ASP ASP B . n 
A 1 177 TYR 177 295 295 TYR TYR B . n 
A 1 178 LEU 178 296 296 LEU LEU B . n 
A 1 179 PRO 179 297 297 PRO PRO B . n 
A 1 180 PRO 180 298 298 PRO PRO B . n 
A 1 181 GLU 181 299 299 GLU GLU B . n 
A 1 182 MET 182 300 300 MET MET B . n 
A 1 183 ILE 183 301 301 ILE ILE B . n 
A 1 184 GLU 184 302 302 GLU GLU B . n 
A 1 185 GLY 185 303 303 GLY GLY B . n 
A 1 186 ARG 186 304 304 ARG ARG B . n 
A 1 187 MET 187 305 305 MET MET B . n 
A 1 188 HIS 188 306 306 HIS HIS B . n 
A 1 189 ASP 189 307 307 ASP ASP B . n 
A 1 190 GLU 190 308 308 GLU GLU B . n 
A 1 191 LYS 191 309 309 LYS LYS B . n 
A 1 192 VAL 192 310 310 VAL VAL B . n 
A 1 193 ASP 193 311 311 ASP ASP B . n 
A 1 194 LEU 194 312 312 LEU LEU B . n 
A 1 195 TRP 195 313 313 TRP TRP B . n 
A 1 196 SER 196 314 314 SER SER B . n 
A 1 197 LEU 197 315 315 LEU LEU B . n 
A 1 198 GLY 198 316 316 GLY GLY B . n 
A 1 199 VAL 199 317 317 VAL VAL B . n 
A 1 200 LEU 200 318 318 LEU LEU B . n 
A 1 201 CYS 201 319 319 CYS CYS B . n 
A 1 202 TYR 202 320 320 TYR TYR B . n 
A 1 203 GLU 203 321 321 GLU GLU B . n 
A 1 204 PHE 204 322 322 PHE PHE B . n 
A 1 205 LEU 205 323 323 LEU LEU B . n 
A 1 206 VAL 206 324 324 VAL VAL B . n 
A 1 207 GLY 207 325 325 GLY GLY B . n 
A 1 208 LYS 208 326 326 LYS LYS B . n 
A 1 209 PRO 209 327 327 PRO PRO B . n 
A 1 210 PRO 210 328 328 PRO PRO B . n 
A 1 211 PHE 211 329 329 PHE PHE B . n 
A 1 212 GLU 212 330 330 GLU GLU B . n 
A 1 213 ALA 213 331 331 ALA ALA B . n 
A 1 214 ASN 214 332 332 ASN ASN B . n 
A 1 215 THR 215 333 333 THR THR B . n 
A 1 216 TYR 216 334 334 TYR TYR B . n 
A 1 217 GLN 217 335 335 GLN GLN B . n 
A 1 218 GLU 218 336 336 GLU GLU B . n 
A 1 219 THR 219 337 337 THR THR B . n 
A 1 220 TYR 220 338 338 TYR TYR B . n 
A 1 221 LYS 221 339 339 LYS LYS B . n 
A 1 222 ARG 222 340 340 ARG ARG B . n 
A 1 223 ILE 223 341 341 ILE ILE B . n 
A 1 224 SER 224 342 342 SER SER B . n 
A 1 225 ARG 225 343 343 ARG ARG B . n 
A 1 226 VAL 226 344 344 VAL VAL B . n 
A 1 227 GLU 227 345 345 GLU GLU B . n 
A 1 228 PHE 228 346 346 PHE PHE B . n 
A 1 229 THR 229 347 347 THR THR B . n 
A 1 230 PHE 230 348 348 PHE PHE B . n 
A 1 231 PRO 231 349 349 PRO PRO B . n 
A 1 232 ASP 232 350 350 ASP ASP B . n 
A 1 233 PHE 233 351 351 PHE PHE B . n 
A 1 234 VAL 234 352 352 VAL VAL B . n 
A 1 235 THR 235 353 353 THR THR B . n 
A 1 236 GLU 236 354 354 GLU GLU B . n 
A 1 237 GLY 237 355 355 GLY GLY B . n 
A 1 238 ALA 238 356 356 ALA ALA B . n 
A 1 239 ARG 239 357 357 ARG ARG B . n 
A 1 240 ASP 240 358 358 ASP ASP B . n 
A 1 241 LEU 241 359 359 LEU LEU B . n 
A 1 242 ILE 242 360 360 ILE ILE B . n 
A 1 243 SER 243 361 361 SER SER B . n 
A 1 244 ARG 244 362 362 ARG ARG B . n 
A 1 245 LEU 245 363 363 LEU LEU B . n 
A 1 246 LEU 246 364 364 LEU LEU B . n 
A 1 247 LYS 247 365 365 LYS LYS B . n 
A 1 248 HIS 248 366 366 HIS HIS B . n 
A 1 249 ASN 249 367 367 ASN ASN B . n 
A 1 250 PRO 250 368 368 PRO PRO B . n 
A 1 251 SER 251 369 369 SER SER B . n 
A 1 252 GLN 252 370 370 GLN GLN B . n 
A 1 253 ARG 253 371 371 ARG ARG B . n 
A 1 254 PRO 254 372 372 PRO PRO B . n 
A 1 255 MET 255 373 373 MET MET B . n 
A 1 256 LEU 256 374 374 LEU LEU B . n 
A 1 257 ARG 257 375 375 ARG ARG B . n 
A 1 258 GLU 258 376 376 GLU GLU B . n 
A 1 259 VAL 259 377 377 VAL VAL B . n 
A 1 260 LEU 260 378 378 LEU LEU B . n 
A 1 261 GLU 261 379 379 GLU GLU B . n 
A 1 262 HIS 262 380 380 HIS HIS B . n 
A 1 263 PRO 263 381 381 PRO PRO B . n 
A 1 264 TRP 264 382 382 TRP TRP B . n 
A 1 265 ILE 265 383 383 ILE ILE B . n 
A 1 266 THR 266 384 384 THR THR B . n 
A 1 267 ALA 267 385 385 ALA ALA B . n 
A 1 268 ASN 268 386 386 ASN ASN B . n 
A 1 269 SER 269 387 387 SER SER B . n 
A 1 270 SER 270 388 388 SER SER B . n 
A 1 271 LYS 271 389 ?   ?   ?   B . n 
A 1 272 PRO 272 390 ?   ?   ?   B . n 
A 1 273 SER 273 391 ?   ?   ?   B . n 
A 1 274 ASN 274 392 ?   ?   ?   B . n 
A 1 275 SER 275 393 ?   ?   ?   B . n 
A 1 276 GLN 276 394 ?   ?   ?   B . n 
A 1 277 ASN 277 395 ?   ?   ?   B . n 
A 1 278 LYS 278 396 ?   ?   ?   B . n 
A 1 279 GLU 279 397 ?   ?   ?   B . n 
A 1 280 SER 280 398 ?   ?   ?   B . n 
A 1 281 ALA 281 399 ?   ?   ?   B . n 
A 1 282 SER 282 400 ?   ?   ?   B . n 
A 1 283 LYS 283 401 ?   ?   ?   B . n 
A 1 284 GLN 284 402 ?   ?   ?   B . n 
A 1 285 SER 285 403 ?   ?   ?   B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        OGR 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   OGR 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 OGR 1   501 401 OGR LIG B . 
C 3 HOH 1   601 100 HOH HOH B . 
C 3 HOH 2   602 39  HOH HOH B . 
C 3 HOH 3   603 114 HOH HOH B . 
C 3 HOH 4   604 86  HOH HOH B . 
C 3 HOH 5   605 104 HOH HOH B . 
C 3 HOH 6   606 77  HOH HOH B . 
C 3 HOH 7   607 99  HOH HOH B . 
C 3 HOH 8   608 14  HOH HOH B . 
C 3 HOH 9   609 28  HOH HOH B . 
C 3 HOH 10  610 54  HOH HOH B . 
C 3 HOH 11  611 7   HOH HOH B . 
C 3 HOH 12  612 33  HOH HOH B . 
C 3 HOH 13  613 80  HOH HOH B . 
C 3 HOH 14  614 66  HOH HOH B . 
C 3 HOH 15  615 21  HOH HOH B . 
C 3 HOH 16  616 64  HOH HOH B . 
C 3 HOH 17  617 40  HOH HOH B . 
C 3 HOH 18  618 17  HOH HOH B . 
C 3 HOH 19  619 30  HOH HOH B . 
C 3 HOH 20  620 5   HOH HOH B . 
C 3 HOH 21  621 8   HOH HOH B . 
C 3 HOH 22  622 79  HOH HOH B . 
C 3 HOH 23  623 47  HOH HOH B . 
C 3 HOH 24  624 48  HOH HOH B . 
C 3 HOH 25  625 112 HOH HOH B . 
C 3 HOH 26  626 88  HOH HOH B . 
C 3 HOH 27  627 73  HOH HOH B . 
C 3 HOH 28  628 57  HOH HOH B . 
C 3 HOH 29  629 113 HOH HOH B . 
C 3 HOH 30  630 90  HOH HOH B . 
C 3 HOH 31  631 41  HOH HOH B . 
C 3 HOH 32  632 56  HOH HOH B . 
C 3 HOH 33  633 16  HOH HOH B . 
C 3 HOH 34  634 65  HOH HOH B . 
C 3 HOH 35  635 23  HOH HOH B . 
C 3 HOH 36  636 34  HOH HOH B . 
C 3 HOH 37  637 31  HOH HOH B . 
C 3 HOH 38  638 46  HOH HOH B . 
C 3 HOH 39  639 6   HOH HOH B . 
C 3 HOH 40  640 12  HOH HOH B . 
C 3 HOH 41  641 83  HOH HOH B . 
C 3 HOH 42  642 2   HOH HOH B . 
C 3 HOH 43  643 95  HOH HOH B . 
C 3 HOH 44  644 22  HOH HOH B . 
C 3 HOH 45  645 94  HOH HOH B . 
C 3 HOH 46  646 53  HOH HOH B . 
C 3 HOH 47  647 19  HOH HOH B . 
C 3 HOH 48  648 59  HOH HOH B . 
C 3 HOH 49  649 20  HOH HOH B . 
C 3 HOH 50  650 10  HOH HOH B . 
C 3 HOH 51  651 52  HOH HOH B . 
C 3 HOH 52  652 71  HOH HOH B . 
C 3 HOH 53  653 1   HOH HOH B . 
C 3 HOH 54  654 24  HOH HOH B . 
C 3 HOH 55  655 74  HOH HOH B . 
C 3 HOH 56  656 4   HOH HOH B . 
C 3 HOH 57  657 62  HOH HOH B . 
C 3 HOH 58  658 38  HOH HOH B . 
C 3 HOH 59  659 27  HOH HOH B . 
C 3 HOH 60  660 101 HOH HOH B . 
C 3 HOH 61  661 3   HOH HOH B . 
C 3 HOH 62  662 78  HOH HOH B . 
C 3 HOH 63  663 51  HOH HOH B . 
C 3 HOH 64  664 50  HOH HOH B . 
C 3 HOH 65  665 70  HOH HOH B . 
C 3 HOH 66  666 68  HOH HOH B . 
C 3 HOH 67  667 60  HOH HOH B . 
C 3 HOH 68  668 93  HOH HOH B . 
C 3 HOH 69  669 69  HOH HOH B . 
C 3 HOH 70  670 36  HOH HOH B . 
C 3 HOH 71  671 26  HOH HOH B . 
C 3 HOH 72  672 9   HOH HOH B . 
C 3 HOH 73  673 81  HOH HOH B . 
C 3 HOH 74  674 42  HOH HOH B . 
C 3 HOH 75  675 32  HOH HOH B . 
C 3 HOH 76  676 97  HOH HOH B . 
C 3 HOH 77  677 102 HOH HOH B . 
C 3 HOH 78  678 61  HOH HOH B . 
C 3 HOH 79  679 29  HOH HOH B . 
C 3 HOH 80  680 35  HOH HOH B . 
C 3 HOH 81  681 98  HOH HOH B . 
C 3 HOH 82  682 117 HOH HOH B . 
C 3 HOH 83  683 37  HOH HOH B . 
C 3 HOH 84  684 96  HOH HOH B . 
C 3 HOH 85  685 82  HOH HOH B . 
C 3 HOH 86  686 11  HOH HOH B . 
C 3 HOH 87  687 75  HOH HOH B . 
C 3 HOH 88  688 55  HOH HOH B . 
C 3 HOH 89  689 63  HOH HOH B . 
C 3 HOH 90  690 15  HOH HOH B . 
C 3 HOH 91  691 107 HOH HOH B . 
C 3 HOH 92  692 87  HOH HOH B . 
C 3 HOH 93  693 58  HOH HOH B . 
C 3 HOH 94  694 13  HOH HOH B . 
C 3 HOH 95  695 67  HOH HOH B . 
C 3 HOH 96  696 25  HOH HOH B . 
C 3 HOH 97  697 44  HOH HOH B . 
C 3 HOH 98  698 89  HOH HOH B . 
C 3 HOH 99  699 115 HOH HOH B . 
C 3 HOH 100 700 116 HOH HOH B . 
C 3 HOH 101 701 18  HOH HOH B . 
C 3 HOH 102 702 91  HOH HOH B . 
C 3 HOH 103 703 103 HOH HOH B . 
C 3 HOH 104 704 109 HOH HOH B . 
C 3 HOH 105 705 43  HOH HOH B . 
C 3 HOH 106 706 85  HOH HOH B . 
C 3 HOH 107 707 92  HOH HOH B . 
C 3 HOH 108 708 72  HOH HOH B . 
C 3 HOH 109 709 76  HOH HOH B . 
C 3 HOH 110 710 111 HOH HOH B . 
C 3 HOH 111 711 110 HOH HOH B . 
C 3 HOH 112 712 49  HOH HOH B . 
C 3 HOH 113 713 45  HOH HOH B . 
C 3 HOH 114 714 108 HOH HOH B . 
C 3 HOH 115 715 84  HOH HOH B . 
C 3 HOH 116 716 118 HOH HOH B . 
C 3 HOH 117 717 106 HOH HOH B . 
C 3 HOH 118 718 105 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 B GLN 127 ? CG  ? A GLN 9   CG  
2  1 Y 1 B GLN 127 ? CD  ? A GLN 9   CD  
3  1 Y 1 B GLN 127 ? OE1 ? A GLN 9   OE1 
4  1 Y 1 B GLN 127 ? NE2 ? A GLN 9   NE2 
5  1 Y 1 B GLN 154 ? CG  ? A GLN 36  CG  
6  1 Y 1 B GLN 154 ? CD  ? A GLN 36  CD  
7  1 Y 1 B GLN 154 ? OE1 ? A GLN 36  OE1 
8  1 Y 1 B GLN 154 ? NE2 ? A GLN 36  NE2 
9  1 Y 1 B PHE 157 ? CG  ? A PHE 39  CG  
10 1 Y 1 B PHE 157 ? CD1 ? A PHE 39  CD1 
11 1 Y 1 B PHE 157 ? CD2 ? A PHE 39  CD2 
12 1 Y 1 B PHE 157 ? CE1 ? A PHE 39  CE1 
13 1 Y 1 B PHE 157 ? CE2 ? A PHE 39  CE2 
14 1 Y 1 B PHE 157 ? CZ  ? A PHE 39  CZ  
15 1 Y 1 B ARG 189 ? CG  ? A ARG 71  CG  
16 1 Y 1 B ARG 189 ? CD  ? A ARG 71  CD  
17 1 Y 1 B ARG 189 ? NE  ? A ARG 71  NE  
18 1 Y 1 B ARG 189 ? CZ  ? A ARG 71  CZ  
19 1 Y 1 B ARG 189 ? NH1 ? A ARG 71  NH1 
20 1 Y 1 B ARG 189 ? NH2 ? A ARG 71  NH2 
21 1 Y 1 B GLN 335 ? CG  ? A GLN 217 CG  
22 1 Y 1 B GLN 335 ? CD  ? A GLN 217 CD  
23 1 Y 1 B GLN 335 ? OE1 ? A GLN 217 OE1 
24 1 Y 1 B GLN 335 ? NE2 ? A GLN 217 NE2 
25 1 Y 0 B GLN 335 ? CA  A A GLN 217 CA  
26 1 Y 0 B GLN 335 ? CB  A A GLN 217 CB  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.1_4122 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? .           3 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot     ? ? ? 0.8.9.2     4 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9BZL 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     83.752 
_cell.length_a_esd                 ? 
_cell.length_b                     83.752 
_cell.length_b_esd                 ? 
_cell.length_c                     77.540 
_cell.length_c_esd                 ? 
_cell.volume                       471028.084 
_cell.volume_esd                   ? 
_cell.Z_PDB                        6 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9BZL 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                154 
_symmetry.space_group_name_Hall            
;P 32 2"
;
_symmetry.space_group_name_H-M             'P 32 2 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9BZL 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.38 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          48.40 
_exptl_crystal.description                  'Hexagonal Rod' 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.4 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;0.1 M Sodium Citrate
15 mg/ml AurA
;
_exptl_crystal_grow.pdbx_pH_range   5.4-5.6 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS EIGER X 16M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2021-04-12 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.98 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'APS BEAMLINE 24-ID-E' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.98 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   24-ID-E 
_diffrn_source.pdbx_synchrotron_site       APS 
# 
_reflns.B_iso_Wilson_estimate                          41.92 
_reflns.entry_id                                       9BZL 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.81 
_reflns.d_resolution_low                               52.97 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     54645 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.6 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                5.1 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          20.8 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.054 
_reflns.pdbx_Rpim_I_all                                0.024 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.998 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.048 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.81 
_reflns_shell.d_res_low                                     1.87 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           ? 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             14435 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               0.476 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.559 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          98.4 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.994 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               45.28 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9BZL 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.81 
_refine.ls_d_res_low                             52.97 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     54645 
_refine.ls_number_reflns_R_free                  3756 
_refine.ls_number_reflns_R_work                  50889 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.17 
_refine.ls_percent_reflns_R_free                 6.87 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1917 
_refine.ls_R_factor_R_free                       0.2139 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1899 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.36 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 26.0433 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2419 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.81 
_refine_hist.d_res_low                        52.97 
_refine_hist.number_atoms_solvent             118 
_refine_hist.number_atoms_total               2275 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        2127 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         30 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0088 ? 2216 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.0340 ? 3006 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0620 ? 323  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0074 ? 381  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 7.0990 ? 312  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.81 1.83  . . 132 1711 90.30 . . . . 0.3690 . . . . . . . . . . . 0.4126 
'X-RAY DIFFRACTION' 1.83 1.85  . . 140 1901 99.42 . . . . 0.3288 . . . . . . . . . . . 0.3359 
'X-RAY DIFFRACTION' 1.85 1.88  . . 142 1889 99.12 . . . . 0.3057 . . . . . . . . . . . 0.3667 
'X-RAY DIFFRACTION' 1.88 1.91  . . 140 1951 99.19 . . . . 0.2858 . . . . . . . . . . . 0.2554 
'X-RAY DIFFRACTION' 1.91 1.94  . . 147 1902 98.65 . . . . 0.2612 . . . . . . . . . . . 0.3210 
'X-RAY DIFFRACTION' 1.94 1.97  . . 135 1852 98.42 . . . . 0.2588 . . . . . . . . . . . 0.2706 
'X-RAY DIFFRACTION' 1.97 2.00  . . 136 1888 98.40 . . . . 0.2469 . . . . . . . . . . . 0.2674 
'X-RAY DIFFRACTION' 2.00 2.03  . . 141 1931 99.19 . . . . 0.2466 . . . . . . . . . . . 0.2703 
'X-RAY DIFFRACTION' 2.03 2.07  . . 136 1841 99.45 . . . . 0.2500 . . . . . . . . . . . 0.2623 
'X-RAY DIFFRACTION' 2.07 2.11  . . 145 1982 99.35 . . . . 0.2262 . . . . . . . . . . . 0.2987 
'X-RAY DIFFRACTION' 2.11 2.15  . . 136 1905 99.22 . . . . 0.2066 . . . . . . . . . . . 0.2662 
'X-RAY DIFFRACTION' 2.15 2.20  . . 134 1890 99.12 . . . . 0.2105 . . . . . . . . . . . 0.2326 
'X-RAY DIFFRACTION' 2.20 2.25  . . 138 1886 98.73 . . . . 0.2168 . . . . . . . . . . . 0.2008 
'X-RAY DIFFRACTION' 2.25 2.31  . . 137 1883 99.07 . . . . 0.2122 . . . . . . . . . . . 0.2739 
'X-RAY DIFFRACTION' 2.31 2.37  . . 141 1943 99.43 . . . . 0.2025 . . . . . . . . . . . 0.2487 
'X-RAY DIFFRACTION' 2.37 2.44  . . 139 1877 98.97 . . . . 0.2076 . . . . . . . . . . . 0.2924 
'X-RAY DIFFRACTION' 2.44 2.52  . . 132 1899 98.54 . . . . 0.2210 . . . . . . . . . . . 0.2703 
'X-RAY DIFFRACTION' 2.52 2.61  . . 147 1903 98.18 . . . . 0.2085 . . . . . . . . . . . 0.2366 
'X-RAY DIFFRACTION' 2.61 2.71  . . 139 1861 97.80 . . . . 0.1962 . . . . . . . . . . . 0.2174 
'X-RAY DIFFRACTION' 2.71 2.83  . . 137 1898 98.07 . . . . 0.2087 . . . . . . . . . . . 0.2269 
'X-RAY DIFFRACTION' 2.84 2.98  . . 137 1890 98.21 . . . . 0.2048 . . . . . . . . . . . 0.1977 
'X-RAY DIFFRACTION' 2.98 3.17  . . 133 1892 97.73 . . . . 0.2045 . . . . . . . . . . . 0.2213 
'X-RAY DIFFRACTION' 3.17 3.42  . . 149 1826 96.91 . . . . 0.1817 . . . . . . . . . . . 0.1799 
'X-RAY DIFFRACTION' 3.42 3.76  . . 136 1836 95.87 . . . . 0.1703 . . . . . . . . . . . 0.1839 
'X-RAY DIFFRACTION' 3.76 4.30  . . 134 1856 96.65 . . . . 0.1576 . . . . . . . . . . . 0.1550 
'X-RAY DIFFRACTION' 4.30 5.41  . . 142 1885 98.06 . . . . 0.1544 . . . . . . . . . . . 0.1966 
'X-RAY DIFFRACTION' 5.42 52.97 . . 151 1911 98.94 . . . . 0.1786 . . . . . . . . . . . 0.2214 
# 
_struct.entry_id                     9BZL 
_struct.title                        'Targeting N-Myc in Neuroblastoma with Selective Aurora Kinase A Degraders' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9BZL 
_struct_keywords.text            'Aurora A Kinase, AurA Kinase, N-Myc degrader, AurA Inhibitor, SIGNALING PROTEIN' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    AURKA_HUMAN 
_struct_ref.pdbx_db_accession          O14965 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;ESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFH
DATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHA
PSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLIS
RLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
;
_struct_ref.pdbx_align_begin           122 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9BZL 
_struct_ref_seq.pdbx_strand_id                B 
_struct_ref_seq.seq_align_beg                 4 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 285 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             O14965 
_struct_ref_seq.db_align_beg                  122 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  403 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       122 
_struct_ref_seq.pdbx_auth_seq_align_end       403 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9BZL GLY B 1   ? UNP O14965 ?   ?   'expression tag'      119 1 
1 9BZL ALA B 2   ? UNP O14965 ?   ?   'expression tag'      120 2 
1 9BZL MET B 3   ? UNP O14965 ?   ?   'expression tag'      121 3 
1 9BZL ALA B 172 ? UNP O14965 CYS 290 'engineered mutation' 290 4 
1 9BZL SER B 275 ? UNP O14965 CYS 393 'engineered mutation' 393 5 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ALA A 11  ? GLU A 13  ? ALA B 129 GLU B 131 5 ? 3  
HELX_P HELX_P2  AA2 LYS A 48  ? GLY A 55  ? LYS B 166 GLY B 173 1 ? 8  
HELX_P HELX_P3  AA3 VAL A 56  ? HIS A 69  ? VAL B 174 HIS B 187 1 ? 14 
HELX_P HELX_P4  AA4 THR A 99  ? SER A 108 ? THR B 217 SER B 226 1 ? 10 
HELX_P HELX_P5  AA5 ASP A 111 ? LYS A 132 ? ASP B 229 LYS B 250 1 ? 22 
HELX_P HELX_P6  AA6 LYS A 140 ? GLU A 142 ? LYS B 258 GLU B 260 5 ? 3  
HELX_P HELX_P7  AA7 THR A 169 ? TYR A 177 ? THR B 287 TYR B 295 1 ? 9  
HELX_P HELX_P8  AA8 PRO A 179 ? GLU A 184 ? PRO B 297 GLU B 302 1 ? 6  
HELX_P HELX_P9  AA9 GLU A 190 ? GLY A 207 ? GLU B 308 GLY B 325 1 ? 18 
HELX_P HELX_P10 AB1 THR A 215 ? ARG A 225 ? THR B 333 ARG B 343 1 ? 11 
HELX_P HELX_P11 AB2 THR A 235 ? LEU A 246 ? THR B 353 LEU B 364 1 ? 12 
HELX_P HELX_P12 AB3 ASN A 249 ? ARG A 253 ? ASN B 367 ARG B 371 5 ? 5  
HELX_P HELX_P13 AB4 MET A 255 ? GLU A 261 ? MET B 373 GLU B 379 1 ? 7  
HELX_P HELX_P14 AB5 HIS A 262 ? SER A 269 ? HIS B 380 SER B 387 1 ? 8  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
covale1 covale both ? A THR 169 C ? ? ? 1_555 A TPO 170 N ? ? B THR 287 B TPO 288 1_555 ? ? ? ? ? ? ? 1.332 ? ? 
covale2 covale both ? A TPO 170 C ? ? ? 1_555 A LEU 171 N ? ? B TPO 288 B LEU 289 1_555 ? ? ? ? ? ? ? 1.321 ? ? 
# 
_struct_conn_type.id          covale 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      TPO 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       170 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     . 
_pdbx_modification_feature.modified_residue_label_asym_id     . 
_pdbx_modification_feature.modified_residue_label_seq_id      . 
_pdbx_modification_feature.modified_residue_label_alt_id      . 
_pdbx_modification_feature.auth_comp_id                       TPO 
_pdbx_modification_feature.auth_asym_id                       B 
_pdbx_modification_feature.auth_seq_id                        288 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      . 
_pdbx_modification_feature.modified_residue_auth_asym_id      . 
_pdbx_modification_feature.modified_residue_auth_seq_id       . 
_pdbx_modification_feature.modified_residue_PDB_ins_code      . 
_pdbx_modification_feature.modified_residue_symmetry          . 
_pdbx_modification_feature.comp_id_linking_atom               . 
_pdbx_modification_feature.modified_residue_id_linking_atom   . 
_pdbx_modification_feature.modified_residue_id                THR 
_pdbx_modification_feature.ref_pcm_id                         1 
_pdbx_modification_feature.ref_comp_id                        TPO 
_pdbx_modification_feature.type                               Phosphorylation 
_pdbx_modification_feature.category                           'Named protein modification' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE A 15  ? LYS A 23  ? PHE B 133 LYS B 141 
AA1 2 GLY A 27  ? GLU A 34  ? GLY B 145 GLU B 152 
AA1 3 ILE A 40  ? PHE A 47  ? ILE B 158 PHE B 165 
AA1 4 ARG A 87  ? LEU A 92  ? ARG B 205 LEU B 210 
AA1 5 LEU A 78  ? HIS A 83  ? LEU B 196 HIS B 201 
AA2 1 LEU A 144 ? LEU A 146 ? LEU B 262 LEU B 264 
AA2 2 LEU A 152 ? ILE A 154 ? LEU B 270 ILE B 272 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N LEU A 21  ? N LEU B 139 O VAL A 29  ? O VAL B 147 
AA1 2 3 N ASN A 28  ? N ASN B 146 O VAL A 45  ? O VAL B 163 
AA1 3 4 N LYS A 44  ? N LYS B 162 O LEU A 90  ? O LEU B 208 
AA1 4 5 O ILE A 91  ? O ILE B 209 N TYR A 79  ? N TYR B 197 
AA2 1 2 N LEU A 145 ? N LEU B 263 O LYS A 153 ? O LYS B 271 
# 
_pdbx_entry_details.entry_id                   9BZL 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   B HOH 605 ? ? O B HOH 645 ? ? 1.85 
2 1 O1P B TPO 288 ? ? O B HOH 601 ? ? 2.00 
3 1 O   B HOH 717 ? ? O B HOH 718 ? ? 2.03 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    B 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     681 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     703 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   6_444 
_pdbx_validate_symm_contact.dist              2.09 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP B 202 ? ? -130.42 -155.70 
2 1 SER B 226 ? ? 75.46   -48.13  
3 1 TRP B 277 ? ? 75.80   163.78  
4 1 LEU B 364 ? ? -92.28  41.30   
# 
_pdbx_struct_mod_residue.id               1 
_pdbx_struct_mod_residue.label_asym_id    A 
_pdbx_struct_mod_residue.label_comp_id    TPO 
_pdbx_struct_mod_residue.label_seq_id     170 
_pdbx_struct_mod_residue.auth_asym_id     B 
_pdbx_struct_mod_residue.auth_comp_id     TPO 
_pdbx_struct_mod_residue.auth_seq_id      288 
_pdbx_struct_mod_residue.PDB_ins_code     ? 
_pdbx_struct_mod_residue.parent_comp_id   THR 
_pdbx_struct_mod_residue.details          'modified residue' 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z          
2 -y,x-y,z+2/3   
3 -x+y,-x,z+1/3  
4 x-y,-y,-z+1/3  
5 -x,-x+y,-z+2/3 
6 y,x,-z         
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 B GLY 119 ? A GLY 1   
2  1 Y 1 B ALA 120 ? A ALA 2   
3  1 Y 1 B MET 121 ? A MET 3   
4  1 Y 1 B GLU 122 ? A GLU 4   
5  1 Y 1 B SER 123 ? A SER 5   
6  1 Y 1 B LYS 124 ? A LYS 6   
7  1 Y 1 B LYS 125 ? A LYS 7   
8  1 Y 1 B ARG 126 ? A ARG 8   
9  1 Y 1 B LYS 389 ? A LYS 271 
10 1 Y 1 B PRO 390 ? A PRO 272 
11 1 Y 1 B SER 391 ? A SER 273 
12 1 Y 1 B ASN 392 ? A ASN 274 
13 1 Y 1 B SER 393 ? A SER 275 
14 1 Y 1 B GLN 394 ? A GLN 276 
15 1 Y 1 B ASN 395 ? A ASN 277 
16 1 Y 1 B LYS 396 ? A LYS 278 
17 1 Y 1 B GLU 397 ? A GLU 279 
18 1 Y 1 B SER 398 ? A SER 280 
19 1 Y 1 B ALA 399 ? A ALA 281 
20 1 Y 1 B SER 400 ? A SER 282 
21 1 Y 1 B LYS 401 ? A LYS 283 
22 1 Y 1 B GLN 402 ? A GLN 284 
23 1 Y 1 B SER 403 ? A SER 285 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N     N N N 1   
ALA CA    C N S 2   
ALA C     C N N 3   
ALA O     O N N 4   
ALA CB    C N N 5   
ALA OXT   O N N 6   
ALA H     H N N 7   
ALA H2    H N N 8   
ALA HA    H N N 9   
ALA HB1   H N N 10  
ALA HB2   H N N 11  
ALA HB3   H N N 12  
ALA HXT   H N N 13  
ARG N     N N N 14  
ARG CA    C N S 15  
ARG C     C N N 16  
ARG O     O N N 17  
ARG CB    C N N 18  
ARG CG    C N N 19  
ARG CD    C N N 20  
ARG NE    N N N 21  
ARG CZ    C N N 22  
ARG NH1   N N N 23  
ARG NH2   N N N 24  
ARG OXT   O N N 25  
ARG H     H N N 26  
ARG H2    H N N 27  
ARG HA    H N N 28  
ARG HB2   H N N 29  
ARG HB3   H N N 30  
ARG HG2   H N N 31  
ARG HG3   H N N 32  
ARG HD2   H N N 33  
ARG HD3   H N N 34  
ARG HE    H N N 35  
ARG HH11  H N N 36  
ARG HH12  H N N 37  
ARG HH21  H N N 38  
ARG HH22  H N N 39  
ARG HXT   H N N 40  
ASN N     N N N 41  
ASN CA    C N S 42  
ASN C     C N N 43  
ASN O     O N N 44  
ASN CB    C N N 45  
ASN CG    C N N 46  
ASN OD1   O N N 47  
ASN ND2   N N N 48  
ASN OXT   O N N 49  
ASN H     H N N 50  
ASN H2    H N N 51  
ASN HA    H N N 52  
ASN HB2   H N N 53  
ASN HB3   H N N 54  
ASN HD21  H N N 55  
ASN HD22  H N N 56  
ASN HXT   H N N 57  
ASP N     N N N 58  
ASP CA    C N S 59  
ASP C     C N N 60  
ASP O     O N N 61  
ASP CB    C N N 62  
ASP CG    C N N 63  
ASP OD1   O N N 64  
ASP OD2   O N N 65  
ASP OXT   O N N 66  
ASP H     H N N 67  
ASP H2    H N N 68  
ASP HA    H N N 69  
ASP HB2   H N N 70  
ASP HB3   H N N 71  
ASP HD2   H N N 72  
ASP HXT   H N N 73  
CYS N     N N N 74  
CYS CA    C N R 75  
CYS C     C N N 76  
CYS O     O N N 77  
CYS CB    C N N 78  
CYS SG    S N N 79  
CYS OXT   O N N 80  
CYS H     H N N 81  
CYS H2    H N N 82  
CYS HA    H N N 83  
CYS HB2   H N N 84  
CYS HB3   H N N 85  
CYS HG    H N N 86  
CYS HXT   H N N 87  
GLN N     N N N 88  
GLN CA    C N S 89  
GLN C     C N N 90  
GLN O     O N N 91  
GLN CB    C N N 92  
GLN CG    C N N 93  
GLN CD    C N N 94  
GLN OE1   O N N 95  
GLN NE2   N N N 96  
GLN OXT   O N N 97  
GLN H     H N N 98  
GLN H2    H N N 99  
GLN HA    H N N 100 
GLN HB2   H N N 101 
GLN HB3   H N N 102 
GLN HG2   H N N 103 
GLN HG3   H N N 104 
GLN HE21  H N N 105 
GLN HE22  H N N 106 
GLN HXT   H N N 107 
GLU N     N N N 108 
GLU CA    C N S 109 
GLU C     C N N 110 
GLU O     O N N 111 
GLU CB    C N N 112 
GLU CG    C N N 113 
GLU CD    C N N 114 
GLU OE1   O N N 115 
GLU OE2   O N N 116 
GLU OXT   O N N 117 
GLU H     H N N 118 
GLU H2    H N N 119 
GLU HA    H N N 120 
GLU HB2   H N N 121 
GLU HB3   H N N 122 
GLU HG2   H N N 123 
GLU HG3   H N N 124 
GLU HE2   H N N 125 
GLU HXT   H N N 126 
GLY N     N N N 127 
GLY CA    C N N 128 
GLY C     C N N 129 
GLY O     O N N 130 
GLY OXT   O N N 131 
GLY H     H N N 132 
GLY H2    H N N 133 
GLY HA2   H N N 134 
GLY HA3   H N N 135 
GLY HXT   H N N 136 
HIS N     N N N 137 
HIS CA    C N S 138 
HIS C     C N N 139 
HIS O     O N N 140 
HIS CB    C N N 141 
HIS CG    C Y N 142 
HIS ND1   N Y N 143 
HIS CD2   C Y N 144 
HIS CE1   C Y N 145 
HIS NE2   N Y N 146 
HIS OXT   O N N 147 
HIS H     H N N 148 
HIS H2    H N N 149 
HIS HA    H N N 150 
HIS HB2   H N N 151 
HIS HB3   H N N 152 
HIS HD1   H N N 153 
HIS HD2   H N N 154 
HIS HE1   H N N 155 
HIS HE2   H N N 156 
HIS HXT   H N N 157 
HOH O     O N N 158 
HOH H1    H N N 159 
HOH H2    H N N 160 
ILE N     N N N 161 
ILE CA    C N S 162 
ILE C     C N N 163 
ILE O     O N N 164 
ILE CB    C N S 165 
ILE CG1   C N N 166 
ILE CG2   C N N 167 
ILE CD1   C N N 168 
ILE OXT   O N N 169 
ILE H     H N N 170 
ILE H2    H N N 171 
ILE HA    H N N 172 
ILE HB    H N N 173 
ILE HG12  H N N 174 
ILE HG13  H N N 175 
ILE HG21  H N N 176 
ILE HG22  H N N 177 
ILE HG23  H N N 178 
ILE HD11  H N N 179 
ILE HD12  H N N 180 
ILE HD13  H N N 181 
ILE HXT   H N N 182 
LEU N     N N N 183 
LEU CA    C N S 184 
LEU C     C N N 185 
LEU O     O N N 186 
LEU CB    C N N 187 
LEU CG    C N N 188 
LEU CD1   C N N 189 
LEU CD2   C N N 190 
LEU OXT   O N N 191 
LEU H     H N N 192 
LEU H2    H N N 193 
LEU HA    H N N 194 
LEU HB2   H N N 195 
LEU HB3   H N N 196 
LEU HG    H N N 197 
LEU HD11  H N N 198 
LEU HD12  H N N 199 
LEU HD13  H N N 200 
LEU HD21  H N N 201 
LEU HD22  H N N 202 
LEU HD23  H N N 203 
LEU HXT   H N N 204 
LYS N     N N N 205 
LYS CA    C N S 206 
LYS C     C N N 207 
LYS O     O N N 208 
LYS CB    C N N 209 
LYS CG    C N N 210 
LYS CD    C N N 211 
LYS CE    C N N 212 
LYS NZ    N N N 213 
LYS OXT   O N N 214 
LYS H     H N N 215 
LYS H2    H N N 216 
LYS HA    H N N 217 
LYS HB2   H N N 218 
LYS HB3   H N N 219 
LYS HG2   H N N 220 
LYS HG3   H N N 221 
LYS HD2   H N N 222 
LYS HD3   H N N 223 
LYS HE2   H N N 224 
LYS HE3   H N N 225 
LYS HZ1   H N N 226 
LYS HZ2   H N N 227 
LYS HZ3   H N N 228 
LYS HXT   H N N 229 
MET N     N N N 230 
MET CA    C N S 231 
MET C     C N N 232 
MET O     O N N 233 
MET CB    C N N 234 
MET CG    C N N 235 
MET SD    S N N 236 
MET CE    C N N 237 
MET OXT   O N N 238 
MET H     H N N 239 
MET H2    H N N 240 
MET HA    H N N 241 
MET HB2   H N N 242 
MET HB3   H N N 243 
MET HG2   H N N 244 
MET HG3   H N N 245 
MET HE1   H N N 246 
MET HE2   H N N 247 
MET HE3   H N N 248 
MET HXT   H N N 249 
OGR N1    N N N 250 
OGR N3    N Y N 251 
OGR C5    C Y N 252 
OGR C6    C N N 253 
OGR C7    C Y N 254 
OGR C8    C Y N 255 
OGR C13   C N N 256 
OGR C15   C N N 257 
OGR C1    C N N 258 
OGR "C1'" C Y N 259 
OGR C11   C N N 260 
OGR C12   C N N 261 
OGR C14   C N N 262 
OGR C16   C Y N 263 
OGR C18   C N N 264 
OGR C19   C N N 265 
OGR C2    C N N 266 
OGR "C2'" C Y N 267 
OGR "C3'" C Y N 268 
OGR "C4'" C Y N 269 
OGR "C5'" C Y N 270 
OGR C9    C Y N 271 
OGR CAA   C Y N 272 
OGR N2    N N N 273 
OGR N6    N Y N 274 
OGR N7    N Y N 275 
OGR N9    N N N 276 
OGR NAA   N Y N 277 
OGR O6    O N N 278 
OGR OP3   O N N 279 
OGR H1    H N N 280 
OGR H2    H N N 281 
OGR H3    H N N 282 
OGR H4    H N N 283 
OGR H5    H N N 284 
OGR H6    H N N 285 
OGR H7    H N N 286 
OGR H8    H N N 287 
OGR H9    H N N 288 
OGR H10   H N N 289 
OGR H11   H N N 290 
OGR H12   H N N 291 
OGR H13   H N N 292 
OGR H14   H N N 293 
OGR H15   H N N 294 
OGR H16   H N N 295 
OGR H17   H N N 296 
OGR H18   H N N 297 
OGR H19   H N N 298 
OGR H20   H N N 299 
OGR H21   H N N 300 
OGR H22   H N N 301 
OGR H23   H N N 302 
OGR H24   H N N 303 
OGR H25   H N N 304 
PHE N     N N N 305 
PHE CA    C N S 306 
PHE C     C N N 307 
PHE O     O N N 308 
PHE CB    C N N 309 
PHE CG    C Y N 310 
PHE CD1   C Y N 311 
PHE CD2   C Y N 312 
PHE CE1   C Y N 313 
PHE CE2   C Y N 314 
PHE CZ    C Y N 315 
PHE OXT   O N N 316 
PHE H     H N N 317 
PHE H2    H N N 318 
PHE HA    H N N 319 
PHE HB2   H N N 320 
PHE HB3   H N N 321 
PHE HD1   H N N 322 
PHE HD2   H N N 323 
PHE HE1   H N N 324 
PHE HE2   H N N 325 
PHE HZ    H N N 326 
PHE HXT   H N N 327 
PRO N     N N N 328 
PRO CA    C N S 329 
PRO C     C N N 330 
PRO O     O N N 331 
PRO CB    C N N 332 
PRO CG    C N N 333 
PRO CD    C N N 334 
PRO OXT   O N N 335 
PRO H     H N N 336 
PRO HA    H N N 337 
PRO HB2   H N N 338 
PRO HB3   H N N 339 
PRO HG2   H N N 340 
PRO HG3   H N N 341 
PRO HD2   H N N 342 
PRO HD3   H N N 343 
PRO HXT   H N N 344 
SER N     N N N 345 
SER CA    C N S 346 
SER C     C N N 347 
SER O     O N N 348 
SER CB    C N N 349 
SER OG    O N N 350 
SER OXT   O N N 351 
SER H     H N N 352 
SER H2    H N N 353 
SER HA    H N N 354 
SER HB2   H N N 355 
SER HB3   H N N 356 
SER HG    H N N 357 
SER HXT   H N N 358 
THR N     N N N 359 
THR CA    C N S 360 
THR C     C N N 361 
THR O     O N N 362 
THR CB    C N R 363 
THR OG1   O N N 364 
THR CG2   C N N 365 
THR OXT   O N N 366 
THR H     H N N 367 
THR H2    H N N 368 
THR HA    H N N 369 
THR HB    H N N 370 
THR HG1   H N N 371 
THR HG21  H N N 372 
THR HG22  H N N 373 
THR HG23  H N N 374 
THR HXT   H N N 375 
TPO N     N N N 376 
TPO CA    C N S 377 
TPO CB    C N R 378 
TPO CG2   C N N 379 
TPO OG1   O N N 380 
TPO P     P N N 381 
TPO O1P   O N N 382 
TPO O2P   O N N 383 
TPO O3P   O N N 384 
TPO C     C N N 385 
TPO O     O N N 386 
TPO OXT   O N N 387 
TPO H     H N N 388 
TPO H2    H N N 389 
TPO HA    H N N 390 
TPO HB    H N N 391 
TPO HG21  H N N 392 
TPO HG22  H N N 393 
TPO HG23  H N N 394 
TPO HOP2  H N N 395 
TPO HOP3  H N N 396 
TPO HXT   H N N 397 
TRP N     N N N 398 
TRP CA    C N S 399 
TRP C     C N N 400 
TRP O     O N N 401 
TRP CB    C N N 402 
TRP CG    C Y N 403 
TRP CD1   C Y N 404 
TRP CD2   C Y N 405 
TRP NE1   N Y N 406 
TRP CE2   C Y N 407 
TRP CE3   C Y N 408 
TRP CZ2   C Y N 409 
TRP CZ3   C Y N 410 
TRP CH2   C Y N 411 
TRP OXT   O N N 412 
TRP H     H N N 413 
TRP H2    H N N 414 
TRP HA    H N N 415 
TRP HB2   H N N 416 
TRP HB3   H N N 417 
TRP HD1   H N N 418 
TRP HE1   H N N 419 
TRP HE3   H N N 420 
TRP HZ2   H N N 421 
TRP HZ3   H N N 422 
TRP HH2   H N N 423 
TRP HXT   H N N 424 
TYR N     N N N 425 
TYR CA    C N S 426 
TYR C     C N N 427 
TYR O     O N N 428 
TYR CB    C N N 429 
TYR CG    C Y N 430 
TYR CD1   C Y N 431 
TYR CD2   C Y N 432 
TYR CE1   C Y N 433 
TYR CE2   C Y N 434 
TYR CZ    C Y N 435 
TYR OH    O N N 436 
TYR OXT   O N N 437 
TYR H     H N N 438 
TYR H2    H N N 439 
TYR HA    H N N 440 
TYR HB2   H N N 441 
TYR HB3   H N N 442 
TYR HD1   H N N 443 
TYR HD2   H N N 444 
TYR HE1   H N N 445 
TYR HE2   H N N 446 
TYR HH    H N N 447 
TYR HXT   H N N 448 
VAL N     N N N 449 
VAL CA    C N S 450 
VAL C     C N N 451 
VAL O     O N N 452 
VAL CB    C N N 453 
VAL CG1   C N N 454 
VAL CG2   C N N 455 
VAL OXT   O N N 456 
VAL H     H N N 457 
VAL H2    H N N 458 
VAL HA    H N N 459 
VAL HB    H N N 460 
VAL HG11  H N N 461 
VAL HG12  H N N 462 
VAL HG13  H N N 463 
VAL HG21  H N N 464 
VAL HG22  H N N 465 
VAL HG23  H N N 466 
VAL HXT   H N N 467 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N     CA    sing N N 1   
ALA N     H     sing N N 2   
ALA N     H2    sing N N 3   
ALA CA    C     sing N N 4   
ALA CA    CB    sing N N 5   
ALA CA    HA    sing N N 6   
ALA C     O     doub N N 7   
ALA C     OXT   sing N N 8   
ALA CB    HB1   sing N N 9   
ALA CB    HB2   sing N N 10  
ALA CB    HB3   sing N N 11  
ALA OXT   HXT   sing N N 12  
ARG N     CA    sing N N 13  
ARG N     H     sing N N 14  
ARG N     H2    sing N N 15  
ARG CA    C     sing N N 16  
ARG CA    CB    sing N N 17  
ARG CA    HA    sing N N 18  
ARG C     O     doub N N 19  
ARG C     OXT   sing N N 20  
ARG CB    CG    sing N N 21  
ARG CB    HB2   sing N N 22  
ARG CB    HB3   sing N N 23  
ARG CG    CD    sing N N 24  
ARG CG    HG2   sing N N 25  
ARG CG    HG3   sing N N 26  
ARG CD    NE    sing N N 27  
ARG CD    HD2   sing N N 28  
ARG CD    HD3   sing N N 29  
ARG NE    CZ    sing N N 30  
ARG NE    HE    sing N N 31  
ARG CZ    NH1   sing N N 32  
ARG CZ    NH2   doub N N 33  
ARG NH1   HH11  sing N N 34  
ARG NH1   HH12  sing N N 35  
ARG NH2   HH21  sing N N 36  
ARG NH2   HH22  sing N N 37  
ARG OXT   HXT   sing N N 38  
ASN N     CA    sing N N 39  
ASN N     H     sing N N 40  
ASN N     H2    sing N N 41  
ASN CA    C     sing N N 42  
ASN CA    CB    sing N N 43  
ASN CA    HA    sing N N 44  
ASN C     O     doub N N 45  
ASN C     OXT   sing N N 46  
ASN CB    CG    sing N N 47  
ASN CB    HB2   sing N N 48  
ASN CB    HB3   sing N N 49  
ASN CG    OD1   doub N N 50  
ASN CG    ND2   sing N N 51  
ASN ND2   HD21  sing N N 52  
ASN ND2   HD22  sing N N 53  
ASN OXT   HXT   sing N N 54  
ASP N     CA    sing N N 55  
ASP N     H     sing N N 56  
ASP N     H2    sing N N 57  
ASP CA    C     sing N N 58  
ASP CA    CB    sing N N 59  
ASP CA    HA    sing N N 60  
ASP C     O     doub N N 61  
ASP C     OXT   sing N N 62  
ASP CB    CG    sing N N 63  
ASP CB    HB2   sing N N 64  
ASP CB    HB3   sing N N 65  
ASP CG    OD1   doub N N 66  
ASP CG    OD2   sing N N 67  
ASP OD2   HD2   sing N N 68  
ASP OXT   HXT   sing N N 69  
CYS N     CA    sing N N 70  
CYS N     H     sing N N 71  
CYS N     H2    sing N N 72  
CYS CA    C     sing N N 73  
CYS CA    CB    sing N N 74  
CYS CA    HA    sing N N 75  
CYS C     O     doub N N 76  
CYS C     OXT   sing N N 77  
CYS CB    SG    sing N N 78  
CYS CB    HB2   sing N N 79  
CYS CB    HB3   sing N N 80  
CYS SG    HG    sing N N 81  
CYS OXT   HXT   sing N N 82  
GLN N     CA    sing N N 83  
GLN N     H     sing N N 84  
GLN N     H2    sing N N 85  
GLN CA    C     sing N N 86  
GLN CA    CB    sing N N 87  
GLN CA    HA    sing N N 88  
GLN C     O     doub N N 89  
GLN C     OXT   sing N N 90  
GLN CB    CG    sing N N 91  
GLN CB    HB2   sing N N 92  
GLN CB    HB3   sing N N 93  
GLN CG    CD    sing N N 94  
GLN CG    HG2   sing N N 95  
GLN CG    HG3   sing N N 96  
GLN CD    OE1   doub N N 97  
GLN CD    NE2   sing N N 98  
GLN NE2   HE21  sing N N 99  
GLN NE2   HE22  sing N N 100 
GLN OXT   HXT   sing N N 101 
GLU N     CA    sing N N 102 
GLU N     H     sing N N 103 
GLU N     H2    sing N N 104 
GLU CA    C     sing N N 105 
GLU CA    CB    sing N N 106 
GLU CA    HA    sing N N 107 
GLU C     O     doub N N 108 
GLU C     OXT   sing N N 109 
GLU CB    CG    sing N N 110 
GLU CB    HB2   sing N N 111 
GLU CB    HB3   sing N N 112 
GLU CG    CD    sing N N 113 
GLU CG    HG2   sing N N 114 
GLU CG    HG3   sing N N 115 
GLU CD    OE1   doub N N 116 
GLU CD    OE2   sing N N 117 
GLU OE2   HE2   sing N N 118 
GLU OXT   HXT   sing N N 119 
GLY N     CA    sing N N 120 
GLY N     H     sing N N 121 
GLY N     H2    sing N N 122 
GLY CA    C     sing N N 123 
GLY CA    HA2   sing N N 124 
GLY CA    HA3   sing N N 125 
GLY C     O     doub N N 126 
GLY C     OXT   sing N N 127 
GLY OXT   HXT   sing N N 128 
HIS N     CA    sing N N 129 
HIS N     H     sing N N 130 
HIS N     H2    sing N N 131 
HIS CA    C     sing N N 132 
HIS CA    CB    sing N N 133 
HIS CA    HA    sing N N 134 
HIS C     O     doub N N 135 
HIS C     OXT   sing N N 136 
HIS CB    CG    sing N N 137 
HIS CB    HB2   sing N N 138 
HIS CB    HB3   sing N N 139 
HIS CG    ND1   sing Y N 140 
HIS CG    CD2   doub Y N 141 
HIS ND1   CE1   doub Y N 142 
HIS ND1   HD1   sing N N 143 
HIS CD2   NE2   sing Y N 144 
HIS CD2   HD2   sing N N 145 
HIS CE1   NE2   sing Y N 146 
HIS CE1   HE1   sing N N 147 
HIS NE2   HE2   sing N N 148 
HIS OXT   HXT   sing N N 149 
HOH O     H1    sing N N 150 
HOH O     H2    sing N N 151 
ILE N     CA    sing N N 152 
ILE N     H     sing N N 153 
ILE N     H2    sing N N 154 
ILE CA    C     sing N N 155 
ILE CA    CB    sing N N 156 
ILE CA    HA    sing N N 157 
ILE C     O     doub N N 158 
ILE C     OXT   sing N N 159 
ILE CB    CG1   sing N N 160 
ILE CB    CG2   sing N N 161 
ILE CB    HB    sing N N 162 
ILE CG1   CD1   sing N N 163 
ILE CG1   HG12  sing N N 164 
ILE CG1   HG13  sing N N 165 
ILE CG2   HG21  sing N N 166 
ILE CG2   HG22  sing N N 167 
ILE CG2   HG23  sing N N 168 
ILE CD1   HD11  sing N N 169 
ILE CD1   HD12  sing N N 170 
ILE CD1   HD13  sing N N 171 
ILE OXT   HXT   sing N N 172 
LEU N     CA    sing N N 173 
LEU N     H     sing N N 174 
LEU N     H2    sing N N 175 
LEU CA    C     sing N N 176 
LEU CA    CB    sing N N 177 
LEU CA    HA    sing N N 178 
LEU C     O     doub N N 179 
LEU C     OXT   sing N N 180 
LEU CB    CG    sing N N 181 
LEU CB    HB2   sing N N 182 
LEU CB    HB3   sing N N 183 
LEU CG    CD1   sing N N 184 
LEU CG    CD2   sing N N 185 
LEU CG    HG    sing N N 186 
LEU CD1   HD11  sing N N 187 
LEU CD1   HD12  sing N N 188 
LEU CD1   HD13  sing N N 189 
LEU CD2   HD21  sing N N 190 
LEU CD2   HD22  sing N N 191 
LEU CD2   HD23  sing N N 192 
LEU OXT   HXT   sing N N 193 
LYS N     CA    sing N N 194 
LYS N     H     sing N N 195 
LYS N     H2    sing N N 196 
LYS CA    C     sing N N 197 
LYS CA    CB    sing N N 198 
LYS CA    HA    sing N N 199 
LYS C     O     doub N N 200 
LYS C     OXT   sing N N 201 
LYS CB    CG    sing N N 202 
LYS CB    HB2   sing N N 203 
LYS CB    HB3   sing N N 204 
LYS CG    CD    sing N N 205 
LYS CG    HG2   sing N N 206 
LYS CG    HG3   sing N N 207 
LYS CD    CE    sing N N 208 
LYS CD    HD2   sing N N 209 
LYS CD    HD3   sing N N 210 
LYS CE    NZ    sing N N 211 
LYS CE    HE2   sing N N 212 
LYS CE    HE3   sing N N 213 
LYS NZ    HZ1   sing N N 214 
LYS NZ    HZ2   sing N N 215 
LYS NZ    HZ3   sing N N 216 
LYS OXT   HXT   sing N N 217 
MET N     CA    sing N N 218 
MET N     H     sing N N 219 
MET N     H2    sing N N 220 
MET CA    C     sing N N 221 
MET CA    CB    sing N N 222 
MET CA    HA    sing N N 223 
MET C     O     doub N N 224 
MET C     OXT   sing N N 225 
MET CB    CG    sing N N 226 
MET CB    HB2   sing N N 227 
MET CB    HB3   sing N N 228 
MET CG    SD    sing N N 229 
MET CG    HG2   sing N N 230 
MET CG    HG3   sing N N 231 
MET SD    CE    sing N N 232 
MET CE    HE1   sing N N 233 
MET CE    HE2   sing N N 234 
MET CE    HE3   sing N N 235 
MET OXT   HXT   sing N N 236 
OGR C1    N2    sing N N 237 
OGR OP3   C2    doub N N 238 
OGR N2    C2    sing N N 239 
OGR C2    "C4'" sing N N 240 
OGR "C4'" "C3'" doub Y N 241 
OGR "C4'" "C5'" sing Y N 242 
OGR C14   C13   sing N N 243 
OGR C14   C15   sing N N 244 
OGR C13   C12   sing N N 245 
OGR "C3'" "C2'" sing Y N 246 
OGR "C5'" NAA   doub Y N 247 
OGR C15   C11   sing N N 248 
OGR "C2'" "C1'" doub Y N 249 
OGR C12   C11   sing N N 250 
OGR C11   N7    sing N N 251 
OGR NAA   "C1'" sing Y N 252 
OGR "C1'" N9    sing N N 253 
OGR N6    C16   doub Y N 254 
OGR N6    CAA   sing Y N 255 
OGR N7    C16   sing Y N 256 
OGR N7    C5    sing Y N 257 
OGR C18   N1    sing N N 258 
OGR C19   N1    sing N N 259 
OGR N9    CAA   sing N N 260 
OGR N1    C6    sing N N 261 
OGR C16   C8    sing Y N 262 
OGR CAA   N3    doub Y N 263 
OGR C6    O6    doub N N 264 
OGR C6    C5    sing N N 265 
OGR C5    C9    doub Y N 266 
OGR C8    C9    sing Y N 267 
OGR C8    C7    doub Y N 268 
OGR N3    C7    sing Y N 269 
OGR C7    H1    sing N N 270 
OGR C13   H2    sing N N 271 
OGR C13   H3    sing N N 272 
OGR C15   H4    sing N N 273 
OGR C15   H5    sing N N 274 
OGR C1    H6    sing N N 275 
OGR C1    H7    sing N N 276 
OGR C1    H8    sing N N 277 
OGR C11   H9    sing N N 278 
OGR C12   H10   sing N N 279 
OGR C12   H11   sing N N 280 
OGR C14   H12   sing N N 281 
OGR C14   H13   sing N N 282 
OGR C18   H14   sing N N 283 
OGR C18   H15   sing N N 284 
OGR C18   H16   sing N N 285 
OGR C19   H17   sing N N 286 
OGR C19   H18   sing N N 287 
OGR C19   H19   sing N N 288 
OGR "C2'" H20   sing N N 289 
OGR "C3'" H21   sing N N 290 
OGR "C5'" H22   sing N N 291 
OGR C9    H23   sing N N 292 
OGR N2    H24   sing N N 293 
OGR N9    H25   sing N N 294 
PHE N     CA    sing N N 295 
PHE N     H     sing N N 296 
PHE N     H2    sing N N 297 
PHE CA    C     sing N N 298 
PHE CA    CB    sing N N 299 
PHE CA    HA    sing N N 300 
PHE C     O     doub N N 301 
PHE C     OXT   sing N N 302 
PHE CB    CG    sing N N 303 
PHE CB    HB2   sing N N 304 
PHE CB    HB3   sing N N 305 
PHE CG    CD1   doub Y N 306 
PHE CG    CD2   sing Y N 307 
PHE CD1   CE1   sing Y N 308 
PHE CD1   HD1   sing N N 309 
PHE CD2   CE2   doub Y N 310 
PHE CD2   HD2   sing N N 311 
PHE CE1   CZ    doub Y N 312 
PHE CE1   HE1   sing N N 313 
PHE CE2   CZ    sing Y N 314 
PHE CE2   HE2   sing N N 315 
PHE CZ    HZ    sing N N 316 
PHE OXT   HXT   sing N N 317 
PRO N     CA    sing N N 318 
PRO N     CD    sing N N 319 
PRO N     H     sing N N 320 
PRO CA    C     sing N N 321 
PRO CA    CB    sing N N 322 
PRO CA    HA    sing N N 323 
PRO C     O     doub N N 324 
PRO C     OXT   sing N N 325 
PRO CB    CG    sing N N 326 
PRO CB    HB2   sing N N 327 
PRO CB    HB3   sing N N 328 
PRO CG    CD    sing N N 329 
PRO CG    HG2   sing N N 330 
PRO CG    HG3   sing N N 331 
PRO CD    HD2   sing N N 332 
PRO CD    HD3   sing N N 333 
PRO OXT   HXT   sing N N 334 
SER N     CA    sing N N 335 
SER N     H     sing N N 336 
SER N     H2    sing N N 337 
SER CA    C     sing N N 338 
SER CA    CB    sing N N 339 
SER CA    HA    sing N N 340 
SER C     O     doub N N 341 
SER C     OXT   sing N N 342 
SER CB    OG    sing N N 343 
SER CB    HB2   sing N N 344 
SER CB    HB3   sing N N 345 
SER OG    HG    sing N N 346 
SER OXT   HXT   sing N N 347 
THR N     CA    sing N N 348 
THR N     H     sing N N 349 
THR N     H2    sing N N 350 
THR CA    C     sing N N 351 
THR CA    CB    sing N N 352 
THR CA    HA    sing N N 353 
THR C     O     doub N N 354 
THR C     OXT   sing N N 355 
THR CB    OG1   sing N N 356 
THR CB    CG2   sing N N 357 
THR CB    HB    sing N N 358 
THR OG1   HG1   sing N N 359 
THR CG2   HG21  sing N N 360 
THR CG2   HG22  sing N N 361 
THR CG2   HG23  sing N N 362 
THR OXT   HXT   sing N N 363 
TPO N     CA    sing N N 364 
TPO N     H     sing N N 365 
TPO N     H2    sing N N 366 
TPO CA    CB    sing N N 367 
TPO CA    C     sing N N 368 
TPO CA    HA    sing N N 369 
TPO CB    CG2   sing N N 370 
TPO CB    OG1   sing N N 371 
TPO CB    HB    sing N N 372 
TPO CG2   HG21  sing N N 373 
TPO CG2   HG22  sing N N 374 
TPO CG2   HG23  sing N N 375 
TPO OG1   P     sing N N 376 
TPO P     O1P   doub N N 377 
TPO P     O2P   sing N N 378 
TPO P     O3P   sing N N 379 
TPO O2P   HOP2  sing N N 380 
TPO O3P   HOP3  sing N N 381 
TPO C     O     doub N N 382 
TPO C     OXT   sing N N 383 
TPO OXT   HXT   sing N N 384 
TRP N     CA    sing N N 385 
TRP N     H     sing N N 386 
TRP N     H2    sing N N 387 
TRP CA    C     sing N N 388 
TRP CA    CB    sing N N 389 
TRP CA    HA    sing N N 390 
TRP C     O     doub N N 391 
TRP C     OXT   sing N N 392 
TRP CB    CG    sing N N 393 
TRP CB    HB2   sing N N 394 
TRP CB    HB3   sing N N 395 
TRP CG    CD1   doub Y N 396 
TRP CG    CD2   sing Y N 397 
TRP CD1   NE1   sing Y N 398 
TRP CD1   HD1   sing N N 399 
TRP CD2   CE2   doub Y N 400 
TRP CD2   CE3   sing Y N 401 
TRP NE1   CE2   sing Y N 402 
TRP NE1   HE1   sing N N 403 
TRP CE2   CZ2   sing Y N 404 
TRP CE3   CZ3   doub Y N 405 
TRP CE3   HE3   sing N N 406 
TRP CZ2   CH2   doub Y N 407 
TRP CZ2   HZ2   sing N N 408 
TRP CZ3   CH2   sing Y N 409 
TRP CZ3   HZ3   sing N N 410 
TRP CH2   HH2   sing N N 411 
TRP OXT   HXT   sing N N 412 
TYR N     CA    sing N N 413 
TYR N     H     sing N N 414 
TYR N     H2    sing N N 415 
TYR CA    C     sing N N 416 
TYR CA    CB    sing N N 417 
TYR CA    HA    sing N N 418 
TYR C     O     doub N N 419 
TYR C     OXT   sing N N 420 
TYR CB    CG    sing N N 421 
TYR CB    HB2   sing N N 422 
TYR CB    HB3   sing N N 423 
TYR CG    CD1   doub Y N 424 
TYR CG    CD2   sing Y N 425 
TYR CD1   CE1   sing Y N 426 
TYR CD1   HD1   sing N N 427 
TYR CD2   CE2   doub Y N 428 
TYR CD2   HD2   sing N N 429 
TYR CE1   CZ    doub Y N 430 
TYR CE1   HE1   sing N N 431 
TYR CE2   CZ    sing Y N 432 
TYR CE2   HE2   sing N N 433 
TYR CZ    OH    sing N N 434 
TYR OH    HH    sing N N 435 
TYR OXT   HXT   sing N N 436 
VAL N     CA    sing N N 437 
VAL N     H     sing N N 438 
VAL N     H2    sing N N 439 
VAL CA    C     sing N N 440 
VAL CA    CB    sing N N 441 
VAL CA    HA    sing N N 442 
VAL C     O     doub N N 443 
VAL C     OXT   sing N N 444 
VAL CB    CG1   sing N N 445 
VAL CB    CG2   sing N N 446 
VAL CB    HB    sing N N 447 
VAL CG1   HG11  sing N N 448 
VAL CG1   HG12  sing N N 449 
VAL CG1   HG13  sing N N 450 
VAL CG2   HG21  sing N N 451 
VAL CG2   HG22  sing N N 452 
VAL CG2   HG23  sing N N 453 
VAL OXT   HXT   sing N N 454 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Cancer Institute (NIH/NCI)' 'United States' P01-CA234228     1 
'Department of Defense (DOD, United States)'                        'United States' W81XWH-21-1-0674 2 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   5one 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 32 2 1' 
_space_group.name_Hall        
;P 32 2"
;
_space_group.IT_number        154 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9BZL 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.011940 
_atom_sites.fract_transf_matrix[1][2]   0.006894 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.013787 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.012897 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N     . GLN A 1 9   ? -19.16982 3.16598   9.41413   1.000 68.74962 ? 127 GLN B N     1 
ATOM   2    C CA    . GLN A 1 9   ? -20.03359 2.06126   9.00985   1.000 64.22526 ? 127 GLN B CA    1 
ATOM   3    C C     . GLN A 1 9   ? -19.90342 1.77232   7.50328   1.000 62.40451 ? 127 GLN B C     1 
ATOM   4    O O     . GLN A 1 9   ? -18.81407 1.45514   7.01540   1.000 62.39121 ? 127 GLN B O     1 
ATOM   5    C CB    . GLN A 1 9   ? -21.49306 2.36256   9.38131   1.000 63.94715 ? 127 GLN B CB    1 
ATOM   6    N N     . TRP A 1 10  ? -21.00677 1.93243   6.77358   1.000 59.01016 ? 128 TRP B N     1 
ATOM   7    C CA    . TRP A 1 10  ? -21.13225 1.40488   5.41320   1.000 55.38188 ? 128 TRP B CA    1 
ATOM   8    C C     . TRP A 1 10  ? -20.05533 1.88707   4.44825   1.000 55.30788 ? 128 TRP B C     1 
ATOM   9    O O     . TRP A 1 10  ? -19.63611 3.04878   4.47333   1.000 58.18691 ? 128 TRP B O     1 
ATOM   10   C CB    . TRP A 1 10  ? -22.49565 1.78378   4.84330   1.000 55.20835 ? 128 TRP B CB    1 
ATOM   11   C CG    . TRP A 1 10  ? -23.65044 1.30757   5.63769   1.000 57.44770 ? 128 TRP B CG    1 
ATOM   12   C CD1   . TRP A 1 10  ? -24.53122 2.07020   6.35216   1.000 58.75314 ? 128 TRP B CD1   1 
ATOM   13   C CD2   . TRP A 1 10  ? -24.11179 -0.04257  5.73886   1.000 60.14523 ? 128 TRP B CD2   1 
ATOM   14   N NE1   . TRP A 1 10  ? -25.49943 1.26934   6.91463   1.000 60.71027 ? 128 TRP B NE1   1 
ATOM   15   C CE2   . TRP A 1 10  ? -25.26236 -0.03146  6.55266   1.000 60.44428 ? 128 TRP B CE2   1 
ATOM   16   C CE3   . TRP A 1 10  ? -23.65204 -1.26336  5.23512   1.000 61.68841 ? 128 TRP B CE3   1 
ATOM   17   C CZ2   . TRP A 1 10  ? -25.95660 -1.19453  6.88075   1.000 65.28937 ? 128 TRP B CZ2   1 
ATOM   18   C CZ3   . TRP A 1 10  ? -24.34518 -2.41866  5.55706   1.000 62.05911 ? 128 TRP B CZ3   1 
ATOM   19   C CH2   . TRP A 1 10  ? -25.48374 -2.37576  6.37467   1.000 66.55754 ? 128 TRP B CH2   1 
ATOM   20   N N     . ALA A 1 11  ? -19.65151 0.98257   3.55281   1.000 52.64589 ? 129 ALA B N     1 
ATOM   21   C CA    . ALA A 1 11  ? -18.83704 1.30314   2.39040   1.000 52.38008 ? 129 ALA B CA    1 
ATOM   22   C C     . ALA A 1 11  ? -19.37746 0.51996   1.19907   1.000 48.65043 ? 129 ALA B C     1 
ATOM   23   O O     . ALA A 1 11  ? -20.12437 -0.44708  1.36038   1.000 52.31002 ? 129 ALA B O     1 
ATOM   24   C CB    . ALA A 1 11  ? -17.35166 0.97568   2.60521   1.000 53.97882 ? 129 ALA B CB    1 
ATOM   25   N N     . LEU A 1 12  ? -18.97724 0.94006   -0.00233  1.000 49.90113 ? 130 LEU B N     1 
ATOM   26   C CA    . LEU A 1 12  ? -19.43956 0.28052   -1.22401  1.000 49.53601 ? 130 LEU B CA    1 
ATOM   27   C C     . LEU A 1 12  ? -19.15733 -1.21155  -1.19133  1.000 54.51967 ? 130 LEU B C     1 
ATOM   28   O O     . LEU A 1 12  ? -19.94253 -2.01902  -1.71158  1.000 49.29205 ? 130 LEU B O     1 
ATOM   29   C CB    . LEU A 1 12  ? -18.76231 0.91390   -2.43286  1.000 53.39262 ? 130 LEU B CB    1 
ATOM   30   C CG    . LEU A 1 12  ? -19.22469 0.41293   -3.80020  1.000 53.22058 ? 130 LEU B CG    1 
ATOM   31   C CD1   . LEU A 1 12  ? -20.74127 0.63240   -3.96456  1.000 47.48091 ? 130 LEU B CD1   1 
ATOM   32   C CD2   . LEU A 1 12  ? -18.42985 1.11361   -4.91046  1.000 49.99327 ? 130 LEU B CD2   1 
ATOM   33   N N     . GLU A 1 13  ? -18.06374 -1.59233  -0.53455  1.000 51.88255 ? 131 GLU B N     1 
ATOM   34   C CA    . GLU A 1 13  ? -17.58547 -2.96240  -0.52850  1.000 53.18631 ? 131 GLU B CA    1 
ATOM   35   C C     . GLU A 1 13  ? -18.53657 -3.89274  0.21300   1.000 48.46823 ? 131 GLU B C     1 
ATOM   36   O O     . GLU A 1 13  ? -18.45351 -5.11281  0.03835   1.000 52.38469 ? 131 GLU B O     1 
ATOM   37   C CB    . GLU A 1 13  ? -16.20053 -2.97957  0.11881   1.000 58.01691 ? 131 GLU B CB    1 
ATOM   38   C CG    . GLU A 1 13  ? -15.09423 -2.51934  -0.82518  1.000 62.48362 ? 131 GLU B CG    1 
ATOM   39   C CD    . GLU A 1 13  ? -15.31088 -1.06379  -1.28853  1.000 66.00075 ? 131 GLU B CD    1 
ATOM   40   O OE1   . GLU A 1 13  ? -15.60963 -0.18578  -0.43041  1.000 61.43743 ? 131 GLU B OE1   1 
ATOM   41   O OE2   . GLU A 1 13  ? -15.18464 -0.79450  -2.50883  1.000 69.53121 ? 131 GLU B OE2   1 
ATOM   42   N N     . ASP A 1 14  ? -19.44331 -3.34468  1.02381   1.000 49.74550 ? 132 ASP B N     1 
ATOM   43   C CA    . ASP A 1 14  ? -20.43649 -4.12946  1.75013   1.000 45.85588 ? 132 ASP B CA    1 
ATOM   44   C C     . ASP A 1 14  ? -21.55821 -4.63931  0.86322   1.000 48.05068 ? 132 ASP B C     1 
ATOM   45   O O     . ASP A 1 14  ? -22.41398 -5.37912  1.36076   1.000 47.11441 ? 132 ASP B O     1 
ATOM   46   C CB    . ASP A 1 14  ? -21.05039 -3.30267  2.88029   1.000 49.71328 ? 132 ASP B CB    1 
ATOM   47   C CG    . ASP A 1 14  ? -20.01986 -2.83895  3.89184   1.000 55.32065 ? 132 ASP B CG    1 
ATOM   48   O OD1   . ASP A 1 14  ? -19.23169 -3.68103  4.36369   1.000 59.83051 ? 132 ASP B OD1   1 
ATOM   49   O OD2   . ASP A 1 14  ? -19.99850 -1.63894  4.22634   1.000 57.27660 ? 132 ASP B OD2   1 
ATOM   50   N N     . PHE A 1 15  ? -21.58542 -4.27690  -0.41554  1.000 47.78184 ? 133 PHE B N     1 
ATOM   51   C CA    . PHE A 1 15  ? -22.73671 -4.54111  -1.26308  1.000 44.67287 ? 133 PHE B CA    1 
ATOM   52   C C     . PHE A 1 15  ? -22.33592 -5.24503  -2.54832  1.000 45.24970 ? 133 PHE B C     1 
ATOM   53   O O     . PHE A 1 15  ? -21.27625 -4.97233  -3.11858  1.000 45.05595 ? 133 PHE B O     1 
ATOM   54   C CB    . PHE A 1 15  ? -23.49099 -3.22687  -1.59866  1.000 44.33598 ? 133 PHE B CB    1 
ATOM   55   C CG    . PHE A 1 15  ? -23.97514 -2.47747  -0.39015  1.000 47.68993 ? 133 PHE B CG    1 
ATOM   56   C CD1   . PHE A 1 15  ? -25.19904 -2.79912  0.18789   1.000 44.52840 ? 133 PHE B CD1   1 
ATOM   57   C CD2   . PHE A 1 15  ? -23.23094 -1.44509  0.16219   1.000 48.60820 ? 133 PHE B CD2   1 
ATOM   58   C CE1   . PHE A 1 15  ? -25.67214 -2.11404  1.29741   1.000 48.89864 ? 133 PHE B CE1   1 
ATOM   59   C CE2   . PHE A 1 15  ? -23.70027 -0.74836  1.28133   1.000 49.30392 ? 133 PHE B CE2   1 
ATOM   60   C CZ    . PHE A 1 15  ? -24.92192 -1.08756  1.84700   1.000 48.16752 ? 133 PHE B CZ    1 
ATOM   61   N N     . GLU A 1 16  ? -23.18750 -6.17706  -2.97098  1.000 41.72020 ? 134 GLU B N     1 
ATOM   62   C CA    . GLU A 1 16  ? -23.22315 -6.67801  -4.33651  1.000 41.93897 ? 134 GLU B CA    1 
ATOM   63   C C     . GLU A 1 16  ? -24.12884 -5.76860  -5.16046  1.000 39.50362 ? 134 GLU B C     1 
ATOM   64   O O     . GLU A 1 16  ? -25.21094 -5.40237  -4.70635  1.000 40.03672 ? 134 GLU B O     1 
ATOM   65   C CB    . GLU A 1 16  ? -23.77697 -8.10781  -4.36241  1.000 41.29576 ? 134 GLU B CB    1 
ATOM   66   C CG    . GLU A 1 16  ? -22.72302 -9.18467  -4.17904  1.000 41.50573 ? 134 GLU B CG    1 
ATOM   67   C CD    . GLU A 1 16  ? -23.27004 -10.59896 -4.34426  1.000 47.94400 ? 134 GLU B CD    1 
ATOM   68   O OE1   . GLU A 1 16  ? -24.31904 -10.79283 -5.02957  1.000 43.13891 ? 134 GLU B OE1   1 
ATOM   69   O OE2   . GLU A 1 16  ? -22.62385 -11.53017 -3.80915  1.000 50.80741 ? 134 GLU B OE2   1 
ATOM   70   N N     . ILE A 1 17  ? -23.71763 -5.44868  -6.38918  1.000 42.77982 ? 135 ILE B N     1 
ATOM   71   C CA    . ILE A 1 17  ? -24.47973 -4.54889  -7.25802  1.000 40.95250 ? 135 ILE B CA    1 
ATOM   72   C C     . ILE A 1 17  ? -25.08567 -5.33846  -8.40814  1.000 41.98601 ? 135 ILE B C     1 
ATOM   73   O O     . ILE A 1 17  ? -24.40920 -6.16886  -9.02184  1.000 39.83042 ? 135 ILE B O     1 
ATOM   74   C CB    . ILE A 1 17  ? -23.59312 -3.41451  -7.80394  1.000 41.36049 ? 135 ILE B CB    1 
ATOM   75   C CG1   . ILE A 1 17  ? -22.82329 -2.75786  -6.66190  1.000 46.41780 ? 135 ILE B CG1   1 
ATOM   76   C CG2   . ILE A 1 17  ? -24.44300 -2.41569  -8.56245  1.000 41.13968 ? 135 ILE B CG2   1 
ATOM   77   C CD1   . ILE A 1 17  ? -23.69784 -2.01021  -5.70918  1.000 47.99139 ? 135 ILE B CD1   1 
ATOM   78   N N     . GLY A 1 18  ? -26.35864 -5.06211  -8.71329  1.000 37.73065 ? 136 GLY B N     1 
ATOM   79   C CA    . GLY A 1 18  ? -27.01871 -5.60763  -9.88875  1.000 35.18474 ? 136 GLY B CA    1 
ATOM   80   C C     . GLY A 1 18  ? -27.32091 -4.54683  -10.93445 1.000 40.50848 ? 136 GLY B C     1 
ATOM   81   O O     . GLY A 1 18  ? -26.57562 -3.57357  -11.05814 1.000 40.03051 ? 136 GLY B O     1 
ATOM   82   N N     . ARG A 1 19  ? -28.42203 -4.69957  -11.66727 1.000 42.31548 ? 137 ARG B N     1 
ATOM   83   C CA    . ARG A 1 19  ? -28.72915 -3.80361  -12.77915 1.000 46.72680 ? 137 ARG B CA    1 
ATOM   84   C C     . ARG A 1 19  ? -29.19646 -2.43768  -12.27568 1.000 43.59534 ? 137 ARG B C     1 
ATOM   85   O O     . ARG A 1 19  ? -29.71723 -2.31933  -11.16294 1.000 43.67236 ? 137 ARG B O     1 
ATOM   86   C CB    . ARG A 1 19  ? -29.80764 -4.42107  -13.67066 1.000 46.09073 ? 137 ARG B CB    1 
ATOM   87   C CG    . ARG A 1 19  ? -31.24888 -4.32153  -13.08381 1.000 47.59691 ? 137 ARG B CG    1 
ATOM   88   C CD    . ARG A 1 19  ? -32.36881 -4.46803  -14.15123 1.000 54.93139 ? 137 ARG B CD    1 
ATOM   89   N NE    . ARG A 1 19  ? -33.72658 -4.23428  -13.64999 1.000 46.34559 ? 137 ARG B NE    1 
ATOM   90   C CZ    . ARG A 1 19  ? -34.32789 -4.94319  -12.70142 1.000 51.08364 ? 137 ARG B CZ    1 
ATOM   91   N NH1   . ARG A 1 19  ? -33.74425 -5.98846  -12.13962 1.000 52.12777 ? 137 ARG B NH1   1 
ATOM   92   N NH2   . ARG A 1 19  ? -35.55198 -4.59415  -12.30617 1.000 51.82176 ? 137 ARG B NH2   1 
ATOM   93   N N     . PRO A 1 20  ? -29.02594 -1.39014  -13.08274 1.000 42.43963 ? 138 PRO B N     1 
ATOM   94   C CA    . PRO A 1 20  ? -29.65250 -0.10445  -12.74919 1.000 42.08426 ? 138 PRO B CA    1 
ATOM   95   C C     . PRO A 1 20  ? -31.16123 -0.20745  -12.91774 1.000 46.17185 ? 138 PRO B C     1 
ATOM   96   O O     . PRO A 1 20  ? -31.65396 -0.68475  -13.94589 1.000 44.66782 ? 138 PRO B O     1 
ATOM   97   C CB    . PRO A 1 20  ? -29.03627 0.87718   -13.75589 1.000 44.97681 ? 138 PRO B CB    1 
ATOM   98   C CG    . PRO A 1 20  ? -28.61159 0.02834   -14.91119 1.000 45.99312 ? 138 PRO B CG    1 
ATOM   99   C CD    . PRO A 1 20  ? -28.22766 -1.31946  -14.32385 1.000 45.39376 ? 138 PRO B CD    1 
ATOM   100  N N     . LEU A 1 21  ? -31.89112 0.21535   -11.88218 1.000 37.89156 ? 139 LEU B N     1 
ATOM   101  C CA    . LEU A 1 21  ? -33.34487 0.25976   -11.95267 1.000 40.77359 ? 139 LEU B CA    1 
ATOM   102  C C     . LEU A 1 21  ? -33.81789 1.50508   -12.67840 1.000 39.16049 ? 139 LEU B C     1 
ATOM   103  O O     . LEU A 1 21  ? -34.89436 1.49201   -13.29932 1.000 39.06830 ? 139 LEU B O     1 
ATOM   104  C CB    . LEU A 1 21  ? -33.93463 0.22536   -10.54453 1.000 39.87279 ? 139 LEU B CB    1 
ATOM   105  C CG    . LEU A 1 21  ? -33.65129 -1.06073  -9.75328  1.000 42.78042 ? 139 LEU B CG    1 
ATOM   106  C CD1   . LEU A 1 21  ? -34.14644 -0.89837  -8.31428  1.000 38.84980 ? 139 LEU B CD1   1 
ATOM   107  C CD2   . LEU A 1 21  ? -34.32232 -2.24411  -10.42178 1.000 41.40275 ? 139 LEU B CD2   1 
ATOM   108  N N     . GLY A 1 22  ? -33.03362 2.57892   -12.59968 1.000 36.94253 ? 140 GLY B N     1 
ATOM   109  C CA    . GLY A 1 22  ? -33.36008 3.81708   -13.29284 1.000 40.31879 ? 140 GLY B CA    1 
ATOM   110  C C     . GLY A 1 22  ? -32.21584 4.80591   -13.19641 1.000 40.60102 ? 140 GLY B C     1 
ATOM   111  O O     . GLY A 1 22  ? -31.24463 4.59590   -12.46608 1.000 41.22757 ? 140 GLY B O     1 
ATOM   112  N N     . LYS A 1 23  ? -32.35114 5.91489   -13.93220 1.000 39.30723 ? 141 LYS B N     1 
ATOM   113  C CA    . LYS A 1 23  ? -31.31433 6.94101   -13.97787 1.000 39.37567 ? 141 LYS B CA    1 
ATOM   114  C C     . LYS A 1 23  ? -31.94173 8.32414   -13.95676 1.000 41.45652 ? 141 LYS B C     1 
ATOM   115  O O     . LYS A 1 23  ? -33.00974 8.54270   -14.52514 1.000 40.74567 ? 141 LYS B O     1 
ATOM   116  C CB    . LYS A 1 23  ? -30.44190 6.85773   -15.23875 1.000 42.27755 ? 141 LYS B CB    1 
ATOM   117  C CG    . LYS A 1 23  ? -29.85679 5.50447   -15.59201 1.000 48.35303 ? 141 LYS B CG    1 
ATOM   118  C CD    . LYS A 1 23  ? -28.98924 5.71539   -16.83847 1.000 50.75388 ? 141 LYS B CD    1 
ATOM   119  C CE    . LYS A 1 23  ? -29.88262 5.83022   -18.08400 1.000 51.81031 ? 141 LYS B CE    1 
ATOM   120  N NZ    . LYS A 1 23  ? -29.17721 5.52770   -19.37392 1.000 54.86563 ? 141 LYS B NZ    1 
ATOM   121  N N     . GLY A 1 24  ? -31.24432 9.26542   -13.32786 1.000 40.79108 ? 142 GLY B N     1 
ATOM   122  C CA    . GLY A 1 24  ? -31.70461 10.63579  -13.23708 1.000 42.86646 ? 142 GLY B CA    1 
ATOM   123  C C     . GLY A 1 24  ? -30.56424 11.60842  -13.46905 1.000 44.13457 ? 142 GLY B C     1 
ATOM   124  O O     . GLY A 1 24  ? -29.41625 11.20816  -13.67734 1.000 40.80013 ? 142 GLY B O     1 
ATOM   125  N N     . LYS A 1 25  ? -30.91636 12.89979  -13.45377 1.000 43.14961 ? 143 LYS B N     1 
ATOM   126  C CA    . LYS A 1 25  ? -29.92843 13.96903  -13.60312 1.000 46.04849 ? 143 LYS B CA    1 
ATOM   127  C C     . LYS A 1 25  ? -28.76508 13.81642  -12.63531 1.000 46.43704 ? 143 LYS B C     1 
ATOM   128  O O     . LYS A 1 25  ? -27.61211 14.12982  -12.96720 1.000 44.41632 ? 143 LYS B O     1 
ATOM   129  C CB    . LYS A 1 25  ? -30.60928 15.31667  -13.37142 1.000 48.01063 ? 143 LYS B CB    1 
ATOM   130  C CG    . LYS A 1 25  ? -29.66288 16.49887  -13.22970 1.000 53.78126 ? 143 LYS B CG    1 
ATOM   131  C CD    . LYS A 1 25  ? -30.45815 17.74186  -12.83125 1.000 55.35084 ? 143 LYS B CD    1 
ATOM   132  C CE    . LYS A 1 25  ? -29.90296 19.00809  -13.44123 1.000 57.51717 ? 143 LYS B CE    1 
ATOM   133  N NZ    . LYS A 1 25  ? -28.84680 19.66260  -12.64198 1.000 63.08977 ? 143 LYS B NZ    1 
ATOM   134  N N     . PHE A 1 26  ? -29.04552 13.36839  -11.42254 1.000 44.13252 ? 144 PHE B N     1 
ATOM   135  C CA    . PHE A 1 26  ? -28.01277 13.34547  -10.40529 1.000 46.86399 ? 144 PHE B CA    1 
ATOM   136  C C     . PHE A 1 26  ? -27.36536 11.97955  -10.22760 1.000 49.55521 ? 144 PHE B C     1 
ATOM   137  O O     . PHE A 1 26  ? -26.33050 11.89523  -9.56033  1.000 49.74922 ? 144 PHE B O     1 
ATOM   138  C CB    . PHE A 1 26  ? -28.58334 13.85474  -9.07305  1.000 45.61598 ? 144 PHE B CB    1 
ATOM   139  C CG    . PHE A 1 26  ? -29.09880 15.27044  -9.14058  1.000 47.45020 ? 144 PHE B CG    1 
ATOM   140  C CD1   . PHE A 1 26  ? -28.22944 16.32813  -9.34580  1.000 48.54387 ? 144 PHE B CD1   1 
ATOM   141  C CD2   . PHE A 1 26  ? -30.44684 15.53864  -9.00117  1.000 47.08614 ? 144 PHE B CD2   1 
ATOM   142  C CE1   . PHE A 1 26  ? -28.70755 17.63894  -9.41488  1.000 50.30632 ? 144 PHE B CE1   1 
ATOM   143  C CE2   . PHE A 1 26  ? -30.93426 16.83167  -9.06474  1.000 49.96501 ? 144 PHE B CE2   1 
ATOM   144  C CZ    . PHE A 1 26  ? -30.06870 17.88779  -9.26777  1.000 48.44304 ? 144 PHE B CZ    1 
ATOM   145  N N     . GLY A 1 27  ? -27.90550 10.92377  -10.82442 1.000 46.76934 ? 145 GLY B N     1 
ATOM   146  C CA    . GLY A 1 27  ? -27.29448 9.61947   -10.66098 1.000 46.71470 ? 145 GLY B CA    1 
ATOM   147  C C     . GLY A 1 27  ? -28.27890 8.50436   -10.97821 1.000 46.71168 ? 145 GLY B C     1 
ATOM   148  O O     . GLY A 1 27  ? -29.29369 8.72042   -11.64095 1.000 44.43368 ? 145 GLY B O     1 
ATOM   149  N N     . ASN A 1 28  ? -27.94100 7.31172   -10.48837 1.000 43.43499 ? 146 ASN B N     1 
ATOM   150  C CA    . ASN A 1 28  ? -28.66257 6.08861   -10.80548 1.000 41.82375 ? 146 ASN B CA    1 
ATOM   151  C C     . ASN A 1 28  ? -29.06884 5.37096   -9.53622  1.000 39.36562 ? 146 ASN B C     1 
ATOM   152  O O     . ASN A 1 28  ? -28.45540 5.54712   -8.48014  1.000 37.81225 ? 146 ASN B O     1 
ATOM   153  C CB    . ASN A 1 28  ? -27.81222 5.13801   -11.63201 1.000 43.61539 ? 146 ASN B CB    1 
ATOM   154  C CG    . ASN A 1 28  ? -27.15993 5.82761   -12.78575 1.000 50.67664 ? 146 ASN B CG    1 
ATOM   155  O OD1   . ASN A 1 28  ? -27.73561 6.75247   -13.36252 1.000 50.00649 ? 146 ASN B OD1   1 
ATOM   156  N ND2   . ASN A 1 28  ? -25.94102 5.42008   -13.11200 1.000 50.53562 ? 146 ASN B ND2   1 
ATOM   157  N N     . VAL A 1 29  ? -30.09156 4.52853   -9.67309  1.000 37.71717 ? 147 VAL B N     1 
ATOM   158  C CA    . VAL A 1 29  ? -30.53361 3.63285   -8.61507  1.000 39.13873 ? 147 VAL B CA    1 
ATOM   159  C C     . VAL A 1 29  ? -30.27774 2.20578   -9.09242  1.000 39.06270 ? 147 VAL B C     1 
ATOM   160  O O     . VAL A 1 29  ? -30.70726 1.82319   -10.18924 1.000 37.50986 ? 147 VAL B O     1 
ATOM   161  C CB    . VAL A 1 29  ? -32.01743 3.84715   -8.26408  1.000 39.97432 ? 147 VAL B CB    1 
ATOM   162  C CG1   . VAL A 1 29  ? -32.44261 2.88100   -7.16420  1.000 38.23760 ? 147 VAL B CG1   1 
ATOM   163  C CG2   . VAL A 1 29  ? -32.25296 5.28323   -7.82069  1.000 38.00144 ? 147 VAL B CG2   1 
ATOM   164  N N     . TYR A 1 30  ? -29.55135 1.43745   -8.28843  1.000 33.12668 ? 148 TYR B N     1 
ATOM   165  C CA    . TYR A 1 30  ? -29.20122 0.05105   -8.58390  1.000 36.35978 ? 148 TYR B CA    1 
ATOM   166  C C     . TYR A 1 30  ? -29.91469 -0.90268  -7.64735  1.000 36.79762 ? 148 TYR B C     1 
ATOM   167  O O     . TYR A 1 30  ? -30.07154 -0.61708  -6.45237  1.000 36.42497 ? 148 TYR B O     1 
ATOM   168  C CB    . TYR A 1 30  ? -27.69493 -0.20620  -8.41759  1.000 36.96541 ? 148 TYR B CB    1 
ATOM   169  C CG    . TYR A 1 30  ? -26.87107 0.61491   -9.34937  1.000 40.07661 ? 148 TYR B CG    1 
ATOM   170  C CD1   . TYR A 1 30  ? -26.56472 0.15534   -10.62505 1.000 39.88992 ? 148 TYR B CD1   1 
ATOM   171  C CD2   . TYR A 1 30  ? -26.42567 1.87883   -8.97202  1.000 38.91459 ? 148 TYR B CD2   1 
ATOM   172  C CE1   . TYR A 1 30  ? -25.81213 0.92556   -11.49172 1.000 43.51283 ? 148 TYR B CE1   1 
ATOM   173  C CE2   . TYR A 1 30  ? -25.68110 2.64818   -9.82763  1.000 43.63320 ? 148 TYR B CE2   1 
ATOM   174  C CZ    . TYR A 1 30  ? -25.37481 2.17203   -11.08618 1.000 46.41584 ? 148 TYR B CZ    1 
ATOM   175  O OH    . TYR A 1 30  ? -24.63097 2.95372   -11.94083 1.000 47.40281 ? 148 TYR B OH    1 
ATOM   176  N N     . LEU A 1 31  ? -30.31661 -2.04752  -8.18708  1.000 37.49009 ? 149 LEU B N     1 
ATOM   177  C CA    . LEU A 1 31  ? -30.58611 -3.18780  -7.32816  1.000 38.05103 ? 149 LEU B CA    1 
ATOM   178  C C     . LEU A 1 31  ? -29.29199 -3.56662  -6.62682  1.000 38.00043 ? 149 LEU B C     1 
ATOM   179  O O     . LEU A 1 31  ? -28.23809 -3.65886  -7.26655  1.000 37.48204 ? 149 LEU B O     1 
ATOM   180  C CB    . LEU A 1 31  ? -31.10190 -4.36006  -8.16077  1.000 39.10918 ? 149 LEU B CB    1 
ATOM   181  C CG    . LEU A 1 31  ? -31.74941 -5.46251  -7.34062  1.000 44.06809 ? 149 LEU B CG    1 
ATOM   182  C CD1   . LEU A 1 31  ? -33.08449 -4.94214  -6.83565  1.000 41.71304 ? 149 LEU B CD1   1 
ATOM   183  C CD2   . LEU A 1 31  ? -31.95990 -6.69866  -8.18139  1.000 44.35057 ? 149 LEU B CD2   1 
ATOM   184  N N     . ALA A 1 32  ? -29.34889 -3.76160  -5.30862  1.000 35.93556 ? 150 ALA B N     1 
ATOM   185  C CA    . ALA A 1 32  ? -28.13778 -4.11535  -4.58274  1.000 39.43466 ? 150 ALA B CA    1 
ATOM   186  C C     . ALA A 1 32  ? -28.47004 -5.12970  -3.49294  1.000 43.32473 ? 150 ALA B C     1 
ATOM   187  O O     . ALA A 1 32  ? -29.63432 -5.37981  -3.17192  1.000 39.91472 ? 150 ALA B O     1 
ATOM   188  C CB    . ALA A 1 32  ? -27.45451 -2.87689  -3.99459  1.000 35.59250 ? 150 ALA B CB    1 
ATOM   189  N N     . ARG A 1 33  ? -27.42055 -5.73760  -2.93534  1.000 43.56571 ? 151 ARG B N     1 
ATOM   190  C CA    . ARG A 1 33  ? -27.57286 -6.77480  -1.92064  1.000 42.71730 ? 151 ARG B CA    1 
ATOM   191  C C     . ARG A 1 33  ? -26.48888 -6.57913  -0.87549  1.000 44.21847 ? 151 ARG B C     1 
ATOM   192  O O     . ARG A 1 33  ? -25.30733 -6.54330  -1.21672  1.000 43.82254 ? 151 ARG B O     1 
ATOM   193  C CB    . ARG A 1 33  ? -27.47434 -8.17560  -2.54341  1.000 46.67874 ? 151 ARG B CB    1 
ATOM   194  C CG    . ARG A 1 33  ? -27.93917 -9.27818  -1.60865  1.000 52.50895 ? 151 ARG B CG    1 
ATOM   195  C CD    . ARG A 1 33  ? -27.54608 -10.65283 -2.10524  1.000 53.06868 ? 151 ARG B CD    1 
ATOM   196  N NE    . ARG A 1 33  ? -27.96738 -10.88107 -3.48309  1.000 54.67078 ? 151 ARG B NE    1 
ATOM   197  C CZ    . ARG A 1 33  ? -29.13874 -11.39923 -3.82475  1.000 52.36390 ? 151 ARG B CZ    1 
ATOM   198  N NH1   . ARG A 1 33  ? -30.04245 -11.72213 -2.91078  1.000 55.41233 ? 151 ARG B NH1   1 
ATOM   199  N NH2   . ARG A 1 33  ? -29.41638 -11.58275 -5.11630  1.000 47.07394 ? 151 ARG B NH2   1 
ATOM   200  N N     . GLU A 1 34  ? -26.87809 -6.44411  0.38888   1.000 47.45652 ? 152 GLU B N     1 
ATOM   201  C CA    . GLU A 1 34  ? -25.87723 -6.32395  1.44025   1.000 47.60158 ? 152 GLU B CA    1 
ATOM   202  C C     . GLU A 1 34  ? -25.24718 -7.70202  1.65053   1.000 50.86053 ? 152 GLU B C     1 
ATOM   203  O O     . GLU A 1 34  ? -25.95520 -8.70613  1.78330   1.000 51.25870 ? 152 GLU B O     1 
ATOM   204  C CB    . GLU A 1 34  ? -26.52235 -5.75625  2.71285   1.000 51.37402 ? 152 GLU B CB    1 
ATOM   205  C CG    . GLU A 1 34  ? -25.60837 -5.52239  3.92427   1.000 54.40646 ? 152 GLU B CG    1 
ATOM   206  C CD    . GLU A 1 34  ? -24.97006 -6.80367  4.43477   1.000 60.27351 ? 152 GLU B CD    1 
ATOM   207  O OE1   . GLU A 1 34  ? -25.73755 -7.72546  4.78597   1.000 62.66485 ? 152 GLU B OE1   1 
ATOM   208  O OE2   . GLU A 1 34  ? -23.71970 -6.89671  4.47083   1.000 62.02471 ? 152 GLU B OE2   1 
ATOM   209  N N     . LYS A 1 35  ? -23.90936 -7.75377  1.63664   1.000 49.35187 ? 153 LYS B N     1 
ATOM   210  C CA    . LYS A 1 35  ? -23.21096 -9.02980  1.44918   1.000 54.19377 ? 153 LYS B CA    1 
ATOM   211  C C     . LYS A 1 35  ? -23.48603 -10.02305 2.57380   1.000 56.97547 ? 153 LYS B C     1 
ATOM   212  O O     . LYS A 1 35  ? -23.62315 -11.22767 2.32204   1.000 58.33554 ? 153 LYS B O     1 
ATOM   213  C CB    . LYS A 1 35  ? -21.70339 -8.80367  1.32542   1.000 53.97396 ? 153 LYS B CB    1 
ATOM   214  C CG    . LYS A 1 35  ? -21.22185 -8.60167  -0.08776  1.000 50.96038 ? 153 LYS B CG    1 
ATOM   215  C CD    . LYS A 1 35  ? -19.78265 -8.14500  -0.09655  1.000 51.34649 ? 153 LYS B CD    1 
ATOM   216  C CE    . LYS A 1 35  ? -19.39112 -7.67974  -1.48378  1.000 52.38999 ? 153 LYS B CE    1 
ATOM   217  N NZ    . LYS A 1 35  ? -17.96253 -7.31540  -1.53635  1.000 52.45652 ? 153 LYS B NZ    1 
ATOM   218  N N     . GLN A 1 36  ? -23.54171 -9.54890  3.81960   1.000 56.97324 ? 154 GLN B N     1 
ATOM   219  C CA    . GLN A 1 36  ? -23.69131 -10.46368 4.94805   1.000 61.19959 ? 154 GLN B CA    1 
ATOM   220  C C     . GLN A 1 36  ? -25.09744 -11.04563 5.00469   1.000 61.13701 ? 154 GLN B C     1 
ATOM   221  O O     . GLN A 1 36  ? -25.27766 -12.26867 5.00341   1.000 65.22887 ? 154 GLN B O     1 
ATOM   222  C CB    . GLN A 1 36  ? -23.35091 -9.74778  6.25728   1.000 63.05762 ? 154 GLN B CB    1 
ATOM   223  N N     . SER A 1 37  ? -26.11068 -10.18216 5.05716   1.000 60.28113 ? 155 SER B N     1 
ATOM   224  C CA    . SER A 1 37  ? -27.48331 -10.63588 5.24159   1.000 54.66650 ? 155 SER B CA    1 
ATOM   225  C C     . SER A 1 37  ? -28.12745 -11.15946 3.96504   1.000 58.05622 ? 155 SER B C     1 
ATOM   226  O O     . SER A 1 37  ? -29.17400 -11.81206 4.04823   1.000 58.03954 ? 155 SER B O     1 
ATOM   227  C CB    . SER A 1 37  ? -28.33826 -9.49554  5.78526   1.000 61.29359 ? 155 SER B CB    1 
ATOM   228  O OG    . SER A 1 37  ? -28.38180 -8.43104  4.84851   1.000 60.79407 ? 155 SER B OG    1 
ATOM   229  N N     . LYS A 1 38  ? -27.54523 -10.88050 2.79698   1.000 55.08319 ? 156 LYS B N     1 
ATOM   230  C CA    . LYS A 1 38  ? -28.17606 -11.11583 1.49409   1.000 52.70776 ? 156 LYS B CA    1 
ATOM   231  C C     . LYS A 1 38  ? -29.47775 -10.31976 1.32675   1.000 51.55948 ? 156 LYS B C     1 
ATOM   232  O O     . LYS A 1 38  ? -30.30217 -10.65085 0.46373   1.000 52.98893 ? 156 LYS B O     1 
ATOM   233  C CB    . LYS A 1 38  ? -28.44895 -12.60942 1.23414   1.000 54.93681 ? 156 LYS B CB    1 
ATOM   234  C CG    . LYS A 1 38  ? -27.30319 -13.62292 1.42216   1.000 57.79756 ? 156 LYS B CG    1 
ATOM   235  C CD    . LYS A 1 38  ? -25.88555 -13.08076 1.25469   1.000 63.06335 ? 156 LYS B CD    1 
ATOM   236  C CE    . LYS A 1 38  ? -25.42422 -13.17940 -0.20501  1.000 64.07940 ? 156 LYS B CE    1 
ATOM   237  N NZ    . LYS A 1 38  ? -24.10862 -12.51443 -0.47296  1.000 63.53665 ? 156 LYS B NZ    1 
ATOM   238  N N     . PHE A 1 39  ? -29.68738 -9.28089  2.13325   1.000 50.03759 ? 157 PHE B N     1 
ATOM   239  C CA    . PHE A 1 39  ? -30.89767 -8.46883  2.02430   1.000 52.15188 ? 157 PHE B CA    1 
ATOM   240  C C     . PHE A 1 39  ? -30.82371 -7.56548  0.79597   1.000 47.81257 ? 157 PHE B C     1 
ATOM   241  O O     . PHE A 1 39  ? -29.83083 -6.85533  0.59777   1.000 44.49308 ? 157 PHE B O     1 
ATOM   242  C CB    . PHE A 1 39  ? -31.08351 -7.61860  3.27774   1.000 49.63557 ? 157 PHE B CB    1 
ATOM   243  N N     . ILE A 1 40  ? -31.87669 -7.59376  -0.02908  1.000 47.58949 ? 158 ILE B N     1 
ATOM   244  C CA    . ILE A 1 40  ? -31.93379 -6.79172  -1.24906  1.000 44.17981 ? 158 ILE B CA    1 
ATOM   245  C C     . ILE A 1 40  ? -32.43220 -5.39102  -0.91354  1.000 43.17151 ? 158 ILE B C     1 
ATOM   246  O O     . ILE A 1 40  ? -33.40838 -5.22231  -0.17536  1.000 45.02446 ? 158 ILE B O     1 
ATOM   247  C CB    . ILE A 1 40  ? -32.83123 -7.46942  -2.29978  1.000 45.19465 ? 158 ILE B CB    1 
ATOM   248  C CG1   . ILE A 1 40  ? -32.22505 -8.80815  -2.69622  1.000 50.80804 ? 158 ILE B CG1   1 
ATOM   249  C CG2   . ILE A 1 40  ? -33.02857 -6.57026  -3.51002  1.000 43.85595 ? 158 ILE B CG2   1 
ATOM   250  C CD1   . ILE A 1 40  ? -31.18419 -8.67631  -3.76860  1.000 51.33733 ? 158 ILE B CD1   1 
ATOM   251  N N     . LEU A 1 41  ? -31.76754 -4.37977  -1.47003  1.000 41.17867 ? 159 LEU B N     1 
ATOM   252  C CA    . LEU A 1 41  ? -32.12396 -2.99000  -1.24461  1.000 41.73769 ? 159 LEU B CA    1 
ATOM   253  C C     . LEU A 1 41  ? -31.86056 -2.21716  -2.53305  1.000 40.61941 ? 159 LEU B C     1 
ATOM   254  O O     . LEU A 1 41  ? -31.32550 -2.76391  -3.50332  1.000 38.89687 ? 159 LEU B O     1 
ATOM   255  C CB    . LEU A 1 41  ? -31.33107 -2.42934  -0.07009  1.000 40.58729 ? 159 LEU B CB    1 
ATOM   256  C CG    . LEU A 1 41  ? -29.82809 -2.66275  -0.13799  1.000 47.23581 ? 159 LEU B CG    1 
ATOM   257  C CD1   . LEU A 1 41  ? -29.12293 -1.51027  -0.85134  1.000 47.41981 ? 159 LEU B CD1   1 
ATOM   258  C CD2   . LEU A 1 41  ? -29.25625 -2.90986  1.25036   1.000 46.83155 ? 159 LEU B CD2   1 
ATOM   259  N N     . ALA A 1 42  ? -32.22869 -0.93460  -2.53474  1.000 39.21435 ? 160 ALA B N     1 
ATOM   260  C CA    . ALA A 1 42  ? -31.97377 -0.05009  -3.66821  1.000 37.00515 ? 160 ALA B CA    1 
ATOM   261  C C     . ALA A 1 42  ? -30.87110 0.91198   -3.27079  1.000 38.83259 ? 160 ALA B C     1 
ATOM   262  O O     . ALA A 1 42  ? -31.01672 1.66948   -2.30505  1.000 40.43215 ? 160 ALA B O     1 
ATOM   263  C CB    . ALA A 1 42  ? -33.24182 0.70352   -4.09187  1.000 38.76790 ? 160 ALA B CB    1 
ATOM   264  N N     . LEU A 1 43  ? -29.76177 0.86908   -3.99466  1.000 35.86496 ? 161 LEU B N     1 
ATOM   265  C CA    . LEU A 1 43  ? -28.62287 1.73592   -3.73182  1.000 35.07722 ? 161 LEU B CA    1 
ATOM   266  C C     . LEU A 1 43  ? -28.71084 2.90638   -4.69514  1.000 39.69454 ? 161 LEU B C     1 
ATOM   267  O O     . LEU A 1 43  ? -28.54633 2.73483   -5.90768  1.000 40.15557 ? 161 LEU B O     1 
ATOM   268  C CB    . LEU A 1 43  ? -27.30129 0.97745   -3.89636  1.000 33.69045 ? 161 LEU B CB    1 
ATOM   269  C CG    . LEU A 1 43  ? -26.01640 1.67588   -3.44862  1.000 37.49871 ? 161 LEU B CG    1 
ATOM   270  C CD1   . LEU A 1 43  ? -26.07573 1.94233   -1.95405  1.000 44.02006 ? 161 LEU B CD1   1 
ATOM   271  C CD2   . LEU A 1 43  ? -24.74283 0.84243   -3.78148  1.000 39.36622 ? 161 LEU B CD2   1 
ATOM   272  N N     . LYS A 1 44  ? -28.98153 4.08824   -4.16361  1.000 37.64176 ? 162 LYS B N     1 
ATOM   273  C CA    . LYS A 1 44  ? -29.10551 5.29291   -4.97674  1.000 36.53823 ? 162 LYS B CA    1 
ATOM   274  C C     . LYS A 1 44  ? -27.78885 6.06355   -4.90809  1.000 37.11111 ? 162 LYS B C     1 
ATOM   275  O O     . LYS A 1 44  ? -27.36112 6.48812   -3.82587  1.000 38.68098 ? 162 LYS B O     1 
ATOM   276  C CB    . LYS A 1 44  ? -30.28810 6.14020   -4.49477  1.000 36.10660 ? 162 LYS B CB    1 
ATOM   277  C CG    . LYS A 1 44  ? -30.59537 7.36391   -5.34027  1.000 36.84142 ? 162 LYS B CG    1 
ATOM   278  C CD    . LYS A 1 44  ? -32.04025 7.80699   -5.04635  1.000 36.94139 ? 162 LYS B CD    1 
ATOM   279  C CE    . LYS A 1 44  ? -32.48442 8.93265   -5.95601  1.000 38.70421 ? 162 LYS B CE    1 
ATOM   280  N NZ    . LYS A 1 44  ? -33.95948 9.17267   -5.83456  1.000 38.99275 ? 162 LYS B NZ    1 
ATOM   281  N N     . VAL A 1 45  ? -27.14844 6.22293   -6.06184  1.000 36.36143 ? 163 VAL B N     1 
ATOM   282  C CA    . VAL A 1 45  ? -25.81171 6.78453   -6.18214  1.000 39.34035 ? 163 VAL B CA    1 
ATOM   283  C C     . VAL A 1 45  ? -25.93234 8.13639   -6.85752  1.000 43.30531 ? 163 VAL B C     1 
ATOM   284  O O     . VAL A 1 45  ? -26.33298 8.21080   -8.03037  1.000 43.34505 ? 163 VAL B O     1 
ATOM   285  C CB    . VAL A 1 45  ? -24.90391 5.87159   -7.01391  1.000 39.74501 ? 163 VAL B CB    1 
ATOM   286  C CG1   . VAL A 1 45  ? -23.48925 6.43990   -7.07315  1.000 45.67269 ? 163 VAL B CG1   1 
ATOM   287  C CG2   . VAL A 1 45  ? -24.95639 4.43926   -6.48224  1.000 39.72069 ? 163 VAL B CG2   1 
ATOM   288  N N     . LEU A 1 46  ? -25.54901 9.19553   -6.15271  1.000 39.45806 ? 164 LEU B N     1 
ATOM   289  C CA    . LEU A 1 46  ? -25.58402 10.53347  -6.72583  1.000 45.45333 ? 164 LEU B CA    1 
ATOM   290  C C     . LEU A 1 46  ? -24.16737 11.06538  -6.87223  1.000 48.40808 ? 164 LEU B C     1 
ATOM   291  O O     . LEU A 1 46  ? -23.35364 10.95011  -5.95009  1.000 47.00362 ? 164 LEU B O     1 
ATOM   292  C CB    . LEU A 1 46  ? -26.42258 11.48901  -5.88088  1.000 44.12046 ? 164 LEU B CB    1 
ATOM   293  C CG    . LEU A 1 46  ? -27.83996 10.98923  -5.55928  1.000 44.79419 ? 164 LEU B CG    1 
ATOM   294  C CD1   . LEU A 1 46  ? -28.35047 11.62903  -4.28133  1.000 50.49927 ? 164 LEU B CD1   1 
ATOM   295  C CD2   . LEU A 1 46  ? -28.79066 11.19741  -6.72497  1.000 47.41673 ? 164 LEU B CD2   1 
ATOM   296  N N     . PHE A 1 47  ? -23.88115 11.67481  -8.01695  1.000 47.67045 ? 165 PHE B N     1 
ATOM   297  C CA    . PHE A 1 47  ? -22.52842 12.12502  -8.31214  1.000 49.21623 ? 165 PHE B CA    1 
ATOM   298  C C     . PHE A 1 47  ? -22.31355 13.51762  -7.74792  1.000 49.84452 ? 165 PHE B C     1 
ATOM   299  O O     . PHE A 1 47  ? -23.11462 14.42570  -7.99215  1.000 48.45981 ? 165 PHE B O     1 
ATOM   300  C CB    . PHE A 1 47  ? -22.26603 12.09731  -9.81597  1.000 53.38594 ? 165 PHE B CB    1 
ATOM   301  C CG    . PHE A 1 47  ? -22.60761 10.78484  -10.44334 1.000 53.36936 ? 165 PHE B CG    1 
ATOM   302  C CD1   . PHE A 1 47  ? -21.75783 9.69876   -10.28680 1.000 55.91950 ? 165 PHE B CD1   1 
ATOM   303  C CD2   . PHE A 1 47  ? -23.74268 10.63470  -11.21373 1.000 52.89387 ? 165 PHE B CD2   1 
ATOM   304  C CE1   . PHE A 1 47  ? -22.06183 8.47820   -10.86204 1.000 59.07726 ? 165 PHE B CE1   1 
ATOM   305  C CE2   . PHE A 1 47  ? -24.04566 9.42416   -11.80626 1.000 56.61999 ? 165 PHE B CE2   1 
ATOM   306  C CZ    . PHE A 1 47  ? -23.21118 8.34038   -11.62647 1.000 57.71418 ? 165 PHE B CZ    1 
ATOM   307  N N     . LYS A 1 48  ? -21.23630 13.67678  -6.97302  1.000 53.54533 ? 166 LYS B N     1 
ATOM   308  C CA    . LYS A 1 48  ? -20.98221 14.96271  -6.33690  1.000 52.59985 ? 166 LYS B CA    1 
ATOM   309  C C     . LYS A 1 48  ? -20.82821 16.06917  -7.37033  1.000 53.25963 ? 166 LYS B C     1 
ATOM   310  O O     . LYS A 1 48  ? -21.27677 17.19816  -7.14466  1.000 53.88335 ? 166 LYS B O     1 
ATOM   311  C CB    . LYS A 1 48  ? -19.74750 14.87384  -5.44547  1.000 53.87151 ? 166 LYS B CB    1 
ATOM   312  C CG    . LYS A 1 48  ? -19.99314 14.15298  -4.13307  1.000 53.18855 ? 166 LYS B CG    1 
ATOM   313  C CD    . LYS A 1 48  ? -18.72623 14.17320  -3.28316  1.000 54.83910 ? 166 LYS B CD    1 
ATOM   314  C CE    . LYS A 1 48  ? -18.95417 13.56693  -1.91666  1.000 56.61994 ? 166 LYS B CE    1 
ATOM   315  N NZ    . LYS A 1 48  ? -17.64091 13.27200  -1.26617  1.000 54.87059 ? 166 LYS B NZ    1 
ATOM   316  N N     . ALA A 1 49  ? -20.21828 15.76056  -8.51876  1.000 54.06113 ? 167 ALA B N     1 
ATOM   317  C CA    . ALA A 1 49  ? -20.07143 16.76078  -9.57457  1.000 54.39916 ? 167 ALA B CA    1 
ATOM   318  C C     . ALA A 1 49  ? -21.42700 17.31967  -9.99750  1.000 57.32903 ? 167 ALA B C     1 
ATOM   319  O O     . ALA A 1 49  ? -21.59531 18.53664  -10.12786 1.000 53.67334 ? 167 ALA B O     1 
ATOM   320  C CB    . ALA A 1 49  ? -19.34527 16.15342  -10.77545 1.000 54.46586 ? 167 ALA B CB    1 
ATOM   321  N N     . GLN A 1 50  ? -22.41144 16.43634  -10.21258 1.000 53.79801 ? 168 GLN B N     1 
ATOM   322  C CA    . GLN A 1 50  ? -23.74403 16.88041  -10.61383 1.000 52.30290 ? 168 GLN B CA    1 
ATOM   323  C C     . GLN A 1 50  ? -24.42028 17.66386  -9.49981  1.000 51.17196 ? 168 GLN B C     1 
ATOM   324  O O     . GLN A 1 50  ? -25.05256 18.69257  -9.75602  1.000 52.65349 ? 168 GLN B O     1 
ATOM   325  C CB    . GLN A 1 50  ? -24.60620 15.67950  -11.01601 1.000 49.33037 ? 168 GLN B CB    1 
ATOM   326  C CG    . GLN A 1 50  ? -24.18308 15.01543  -12.30738 1.000 53.55375 ? 168 GLN B CG    1 
ATOM   327  C CD    . GLN A 1 50  ? -24.27257 15.93821  -13.51373 1.000 60.03047 ? 168 GLN B CD    1 
ATOM   328  O OE1   . GLN A 1 50  ? -23.28159 16.15176  -14.20710 1.000 63.63709 ? 168 GLN B OE1   1 
ATOM   329  N NE2   . GLN A 1 50  ? -25.48454 16.42022  -13.81661 1.000 59.57698 ? 168 GLN B NE2   1 
ATOM   330  N N     . LEU A 1 51  ? -24.30403 17.19584  -8.25627  1.000 47.57932 ? 169 LEU B N     1 
ATOM   331  C CA    . LEU A 1 51  ? -24.89235 17.93462  -7.14692  1.000 50.33408 ? 169 LEU B CA    1 
ATOM   332  C C     . LEU A 1 51  ? -24.27463 19.32450  -7.02454  1.000 54.95270 ? 169 LEU B C     1 
ATOM   333  O O     . LEU A 1 51  ? -24.99695 20.31060  -6.82950  1.000 54.38622 ? 169 LEU B O     1 
ATOM   334  C CB    . LEU A 1 51  ? -24.73342 17.15770  -5.83543  1.000 52.16078 ? 169 LEU B CB    1 
ATOM   335  C CG    . LEU A 1 51  ? -25.39601 15.77836  -5.73366  1.000 48.91641 ? 169 LEU B CG    1 
ATOM   336  C CD1   . LEU A 1 51  ? -24.85938 15.02313  -4.51347  1.000 51.07992 ? 169 LEU B CD1   1 
ATOM   337  C CD2   . LEU A 1 51  ? -26.91598 15.89156  -5.67865  1.000 45.93287 ? 169 LEU B CD2   1 
ATOM   338  N N     . GLU A 1 52  ? -22.94165 19.42999  -7.14661  1.000 55.78478 ? 170 GLU B N     1 
ATOM   339  C CA    . GLU A 1 52  ? -22.30910 20.74944  -7.06146  1.000 59.12474 ? 170 GLU B CA    1 
ATOM   340  C C     . GLU A 1 52  ? -22.72559 21.63639  -8.22613  1.000 54.98038 ? 170 GLU B C     1 
ATOM   341  O O     . GLU A 1 52  ? -23.06544 22.80867  -8.03229  1.000 57.88051 ? 170 GLU B O     1 
ATOM   342  C CB    . GLU A 1 52  ? -20.77459 20.65471  -7.00087  1.000 60.30446 ? 170 GLU B CB    1 
ATOM   343  C CG    . GLU A 1 52  ? -20.15642 19.66571  -6.03392  1.000 64.54611 ? 170 GLU B CG    1 
ATOM   344  C CD    . GLU A 1 52  ? -18.73264 19.27554  -6.43237  1.000 68.79873 ? 170 GLU B CD    1 
ATOM   345  O OE1   . GLU A 1 52  ? -18.31477 19.62603  -7.55851  1.000 71.86333 ? 170 GLU B OE1   1 
ATOM   346  O OE2   . GLU A 1 52  ? -18.02559 18.62973  -5.62208  1.000 72.80835 ? 170 GLU B OE2   1 
ATOM   347  N N     . LYS A 1 53  ? -22.70761 21.08802  -9.44202  1.000 57.13853 ? 171 LYS B N     1 
ATOM   348  C CA    . LYS A 1 53  ? -23.05801 21.86464  -10.62548 1.000 56.25537 ? 171 LYS B CA    1 
ATOM   349  C C     . LYS A 1 53  ? -24.44013 22.49688  -10.47861 1.000 57.57833 ? 171 LYS B C     1 
ATOM   350  O O     . LYS A 1 53  ? -24.65384 23.64736  -10.88116 1.000 56.40707 ? 171 LYS B O     1 
ATOM   351  C CB    . LYS A 1 53  ? -22.96225 20.94378  -11.84685 1.000 58.34563 ? 171 LYS B CB    1 
ATOM   352  C CG    . LYS A 1 53  ? -22.98220 21.56002  -13.22962 1.000 59.33524 ? 171 LYS B CG    1 
ATOM   353  C CD    . LYS A 1 53  ? -23.68857 20.60728  -14.18380 1.000 61.51553 ? 171 LYS B CD    1 
ATOM   354  C CE    . LYS A 1 53  ? -22.69112 19.88029  -15.08330 1.000 64.00793 ? 171 LYS B CE    1 
ATOM   355  N NZ    . LYS A 1 53  ? -23.37609 18.89906  -16.00196 1.000 64.86263 ? 171 LYS B NZ    1 
ATOM   356  N N     . ALA A 1 54  ? -25.38131 21.77965  -9.86618  1.000 56.93275 ? 172 ALA B N     1 
ATOM   357  C CA    . ALA A 1 54  ? -26.72975 22.29364  -9.67487  1.000 55.85045 ? 172 ALA B CA    1 
ATOM   358  C C     . ALA A 1 54  ? -26.90349 23.05836  -8.36953  1.000 54.89533 ? 172 ALA B C     1 
ATOM   359  O O     . ALA A 1 54  ? -27.97295 23.63833  -8.15022  1.000 58.38807 ? 172 ALA B O     1 
ATOM   360  C CB    . ALA A 1 54  ? -27.75347 21.15063  -9.72716  1.000 52.45352 ? 172 ALA B CB    1 
ATOM   361  N N     . GLY A 1 55  ? -25.90108 23.07150  -7.49723  1.000 55.60830 ? 173 GLY B N     1 
ATOM   362  C CA    . GLY A 1 55  ? -26.02130 23.81040  -6.25309  1.000 56.40442 ? 173 GLY B CA    1 
ATOM   363  C C     . GLY A 1 55  ? -26.99496 23.22462  -5.25536  1.000 56.97245 ? 173 GLY B C     1 
ATOM   364  O O     . GLY A 1 55  ? -27.57896 23.96909  -4.46112  1.000 53.76656 ? 173 GLY B O     1 
ATOM   365  N N     . VAL A 1 56  ? -27.17392 21.90383  -5.25714  1.000 53.06827 ? 174 VAL B N     1 
ATOM   366  C CA    . VAL A 1 56  ? -28.13235 21.24699  -4.37901  1.000 53.09753 ? 174 VAL B CA    1 
ATOM   367  C C     . VAL A 1 56  ? -27.43665 20.42917  -3.30387  1.000 56.25749 ? 174 VAL B C     1 
ATOM   368  O O     . VAL A 1 56  ? -28.09578 19.66426  -2.59399  1.000 53.77381 ? 174 VAL B O     1 
ATOM   369  C CB    . VAL A 1 56  ? -29.11313 20.37003  -5.17663  1.000 52.73216 ? 174 VAL B CB    1 
ATOM   370  C CG1   . VAL A 1 56  ? -29.96582 21.24158  -6.11109  1.000 49.67962 ? 174 VAL B CG1   1 
ATOM   371  C CG2   . VAL A 1 56  ? -28.36843 19.30932  -5.95445  1.000 51.10252 ? 174 VAL B CG2   1 
ATOM   372  N N     . GLU A 1 57  ? -26.10993 20.56453  -3.17362  1.000 54.83841 ? 175 GLU B N     1 
ATOM   373  C CA    . GLU A 1 57  ? -25.37546 19.79268  -2.17464  1.000 58.77440 ? 175 GLU B CA    1 
ATOM   374  C C     . GLU A 1 57  ? -25.90465 20.07490  -0.77397  1.000 57.64535 ? 175 GLU B C     1 
ATOM   375  O O     . GLU A 1 57  ? -26.02175 19.16058  0.04757   1.000 56.93515 ? 175 GLU B O     1 
ATOM   376  C CB    . GLU A 1 57  ? -23.87705 20.10543  -2.26741  1.000 60.30212 ? 175 GLU B CB    1 
ATOM   377  C CG    . GLU A 1 57  ? -22.98732 19.28204  -1.34307  1.000 72.12610 ? 175 GLU B CG    1 
ATOM   378  C CD    . GLU A 1 57  ? -21.91832 18.47987  -2.09185  1.000 76.63626 ? 175 GLU B CD    1 
ATOM   379  O OE1   . GLU A 1 57  ? -21.32364 19.02167  -3.05585  1.000 76.52098 ? 175 GLU B OE1   1 
ATOM   380  O OE2   . GLU A 1 57  ? -21.66905 17.31091  -1.71325  1.000 78.54684 ? 175 GLU B OE2   1 
ATOM   381  N N     . HIS A 1 58  ? -26.26318 21.33065  -0.49550  1.000 55.34682 ? 176 HIS B N     1 
ATOM   382  C CA    . HIS A 1 58  ? -26.81755 21.67029  0.81221   1.000 57.87236 ? 176 HIS B CA    1 
ATOM   383  C C     . HIS A 1 58  ? -28.23775 21.12756  0.97466   1.000 56.20093 ? 176 HIS B C     1 
ATOM   384  O O     . HIS A 1 58  ? -28.62051 20.69754  2.06879   1.000 54.12876 ? 176 HIS B O     1 
ATOM   385  C CB    . HIS A 1 58  ? -26.79247 23.18913  1.00909   1.000 63.98363 ? 176 HIS B CB    1 
ATOM   386  C CG    . HIS A 1 58  ? -25.61574 23.68079  1.79723   1.000 68.78348 ? 176 HIS B CG    1 
ATOM   387  N ND1   . HIS A 1 58  ? -24.31213 23.49056  1.38654   1.000 71.37776 ? 176 HIS B ND1   1 
ATOM   388  C CD2   . HIS A 1 58  ? -25.54543 24.37077  2.96107   1.000 71.38138 ? 176 HIS B CD2   1 
ATOM   389  C CE1   . HIS A 1 58  ? -23.49011 24.03040  2.26894   1.000 67.60316 ? 176 HIS B CE1   1 
ATOM   390  N NE2   . HIS A 1 58  ? -24.21259 24.57212  3.23341   1.000 69.42600 ? 176 HIS B NE2   1 
ATOM   391  N N     . GLN A 1 59  ? -29.03877 21.13887  -0.09403  1.000 55.19322 ? 177 GLN B N     1 
ATOM   392  C CA    . GLN A 1 59  ? -30.37405 20.55050  -0.00054  1.000 55.83041 ? 177 GLN B CA    1 
ATOM   393  C C     . GLN A 1 59  ? -30.31195 19.08280  0.40942   1.000 52.16600 ? 177 GLN B C     1 
ATOM   394  O O     . GLN A 1 59  ? -31.04221 18.64451  1.30768   1.000 52.55466 ? 177 GLN B O     1 
ATOM   395  C CB    . GLN A 1 59  ? -31.12827 20.67834  -1.32020  1.000 53.61320 ? 177 GLN B CB    1 
ATOM   396  C CG    . GLN A 1 59  ? -32.57769 20.23416  -1.12998  1.000 58.63219 ? 177 GLN B CG    1 
ATOM   397  C CD    . GLN A 1 59  ? -33.54980 20.79129  -2.13815  1.000 62.22942 ? 177 GLN B CD    1 
ATOM   398  O OE1   . GLN A 1 59  ? -33.16240 21.16087  -3.25264  1.000 58.21599 ? 177 GLN B OE1   1 
ATOM   399  N NE2   . GLN A 1 59  ? -34.82601 20.82512  -1.76974  1.000 64.56381 ? 177 GLN B NE2   1 
ATOM   400  N N     . LEU A 1 60  ? -29.44416 18.30684  -0.24281  1.000 51.16187 ? 178 LEU B N     1 
ATOM   401  C CA    . LEU A 1 60  ? -29.36765 16.87662  0.04212   1.000 47.93136 ? 178 LEU B CA    1 
ATOM   402  C C     . LEU A 1 60  ? -29.00529 16.60841  1.50347   1.000 51.91097 ? 178 LEU B C     1 
ATOM   403  O O     . LEU A 1 60  ? -29.59629 15.72252  2.13353   1.000 48.43307 ? 178 LEU B O     1 
ATOM   404  C CB    . LEU A 1 60  ? -28.35966 16.21065  -0.90008  1.000 49.21536 ? 178 LEU B CB    1 
ATOM   405  C CG    . LEU A 1 60  ? -28.11868 14.70856  -0.73290  1.000 44.09172 ? 178 LEU B CG    1 
ATOM   406  C CD1   . LEU A 1 60  ? -29.43017 13.92615  -0.86420  1.000 45.81341 ? 178 LEU B CD1   1 
ATOM   407  C CD2   . LEU A 1 60  ? -27.09082 14.22801  -1.76208  1.000 44.18337 ? 178 LEU B CD2   1 
ATOM   408  N N     . ARG A 1 61  ? -28.03259 17.35196  2.05825   1.000 53.23929 ? 179 ARG B N     1 
ATOM   409  C CA    . ARG A 1 61  ? -27.68508 17.19196  3.47424   1.000 52.16635 ? 179 ARG B CA    1 
ATOM   410  C C     . ARG A 1 61  ? -28.91051 17.38505  4.35524   1.000 51.72291 ? 179 ARG B C     1 
ATOM   411  O O     . ARG A 1 61  ? -29.18527 16.58405  5.25576   1.000 52.25024 ? 179 ARG B O     1 
ATOM   412  C CB    . ARG A 1 61  ? -26.60131 18.19714  3.89811   1.000 58.68271 ? 179 ARG B CB    1 
ATOM   413  C CG    . ARG A 1 61  ? -25.48217 18.48458  2.89423   1.000 64.77756 ? 179 ARG B CG    1 
ATOM   414  C CD    . ARG A 1 61  ? -24.14662 18.89661  3.55445   1.000 69.73634 ? 179 ARG B CD    1 
ATOM   415  N NE    . ARG A 1 61  ? -22.99377 18.67123  2.68129   1.000 75.55105 ? 179 ARG B NE    1 
ATOM   416  C CZ    . ARG A 1 61  ? -22.28054 17.55167  2.62834   1.000 78.34718 ? 179 ARG B CZ    1 
ATOM   417  N NH1   . ARG A 1 61  ? -22.53369 16.53000  3.43096   1.000 77.50167 ? 179 ARG B NH1   1 
ATOM   418  N NH2   . ARG A 1 61  ? -21.28117 17.45968  1.75339   1.000 79.45917 ? 179 ARG B NH2   1 
ATOM   419  N N     . ARG A 1 62  ? -29.64480 18.46951  4.11271   1.000 53.55940 ? 180 ARG B N     1 
ATOM   420  C CA    . ARG A 1 62  ? -30.87321 18.76060  4.84276   1.000 53.66043 ? 180 ARG B CA    1 
ATOM   421  C C     . ARG A 1 62  ? -31.88200 17.62640  4.69717   1.000 53.02050 ? 180 ARG B C     1 
ATOM   422  O O     . ARG A 1 62  ? -32.44448 17.14176  5.68737   1.000 53.21745 ? 180 ARG B O     1 
ATOM   423  C CB    . ARG A 1 62  ? -31.42493 20.09087  4.31633   1.000 53.79305 ? 180 ARG B CB    1 
ATOM   424  C CG    . ARG A 1 62  ? -32.80936 20.49293  4.71496   1.000 59.49734 ? 180 ARG B CG    1 
ATOM   425  C CD    . ARG A 1 62  ? -33.06155 21.93994  4.24987   1.000 65.37574 ? 180 ARG B CD    1 
ATOM   426  N NE    . ARG A 1 62  ? -31.84035 22.74550  4.26972   1.000 66.84051 ? 180 ARG B NE    1 
ATOM   427  C CZ    . ARG A 1 62  ? -31.36527 23.42842  3.23249   1.000 69.97538 ? 180 ARG B CZ    1 
ATOM   428  N NH1   . ARG A 1 62  ? -31.98317 23.42788  2.05967   1.000 67.71536 ? 180 ARG B NH1   1 
ATOM   429  N NH2   . ARG A 1 62  ? -30.23747 24.12497  3.37315   1.000 66.44878 ? 180 ARG B NH2   1 
ATOM   430  N N     . GLU A 1 63  ? -32.09060 17.16021  3.46813   1.000 50.36034 ? 181 GLU B N     1 
ATOM   431  C CA    . GLU A 1 63  ? -33.13846 16.18024  3.22056   1.000 48.77139 ? 181 GLU B CA    1 
ATOM   432  C C     . GLU A 1 63  ? -32.75761 14.80973  3.76573   1.000 48.11120 ? 181 GLU B C     1 
ATOM   433  O O     . GLU A 1 63  ? -33.63396 14.04079  4.17655   1.000 45.86808 ? 181 GLU B O     1 
ATOM   434  C CB    . GLU A 1 63  ? -33.42536 16.09264  1.71839   1.000 51.73970 ? 181 GLU B CB    1 
ATOM   435  C CG    . GLU A 1 63  ? -33.99364 17.39083  1.12781   1.000 54.17410 ? 181 GLU B CG    1 
ATOM   436  C CD    . GLU A 1 63  ? -35.45618 17.62648  1.44749   1.000 60.28923 ? 181 GLU B CD    1 
ATOM   437  O OE1   . GLU A 1 63  ? -35.99406 16.97811  2.37406   1.000 55.71969 ? 181 GLU B OE1   1 
ATOM   438  O OE2   . GLU A 1 63  ? -36.05494 18.50795  0.79280   1.000 70.64775 ? 181 GLU B OE2   1 
ATOM   439  N N     . VAL A 1 64  ? -31.46025 14.48109  3.76403   1.000 46.27991 ? 182 VAL B N     1 
ATOM   440  C CA    . VAL A 1 64  ? -31.00539 13.22080  4.34593   1.000 46.68872 ? 182 VAL B CA    1 
ATOM   441  C C     . VAL A 1 64  ? -31.36630 13.16609  5.82698   1.000 46.58856 ? 182 VAL B C     1 
ATOM   442  O O     . VAL A 1 64  ? -31.88491 12.15916  6.32318   1.000 45.19712 ? 182 VAL B O     1 
ATOM   443  C CB    . VAL A 1 64  ? -29.48834 13.04838  4.12235   1.000 47.99298 ? 182 VAL B CB    1 
ATOM   444  C CG1   . VAL A 1 64  ? -28.90229 12.05052  5.12223   1.000 49.22177 ? 182 VAL B CG1   1 
ATOM   445  C CG2   . VAL A 1 64  ? -29.20244 12.61814  2.69715   1.000 44.25402 ? 182 VAL B CG2   1 
ATOM   446  N N     . GLU A 1 65  ? -31.10177 14.25842  6.54954   1.000 50.09947 ? 183 GLU B N     1 
ATOM   447  C CA    . GLU A 1 65  ? -31.41557 14.31556  7.97697   1.000 52.98640 ? 183 GLU B CA    1 
ATOM   448  C C     . GLU A 1 65  ? -32.91738 14.17049  8.21300   1.000 52.37455 ? 183 GLU B C     1 
ATOM   449  O O     . GLU A 1 65  ? -33.34276 13.42776  9.10414   1.000 51.02210 ? 183 GLU B O     1 
ATOM   450  C CB    . GLU A 1 65  ? -30.87733 15.62695  8.56106   1.000 51.52341 ? 183 GLU B CB    1 
ATOM   451  C CG    . GLU A 1 65  ? -31.55138 16.11590  9.84628   1.000 59.26590 ? 183 GLU B CG    1 
ATOM   452  C CD    . GLU A 1 65  ? -31.22341 15.27607  11.06945  1.000 67.75388 ? 183 GLU B CD    1 
ATOM   453  O OE1   . GLU A 1 65  ? -30.20513 14.54271  11.04707  1.000 70.01600 ? 183 GLU B OE1   1 
ATOM   454  O OE2   . GLU A 1 65  ? -31.99198 15.35169  12.05960  1.000 69.84695 ? 183 GLU B OE2   1 
ATOM   455  N N     . ILE A 1 66  ? -33.73221 14.84163  7.39209   1.000 51.31674 ? 184 ILE B N     1 
ATOM   456  C CA    . ILE A 1 66  ? -35.19029 14.69880  7.46865   1.000 51.41866 ? 184 ILE B CA    1 
ATOM   457  C C     . ILE A 1 66  ? -35.60580 13.25536  7.21332   1.000 50.62181 ? 184 ILE B C     1 
ATOM   458  O O     . ILE A 1 66  ? -36.29608 12.62865  8.03123   1.000 51.55476 ? 184 ILE B O     1 
ATOM   459  C CB    . ILE A 1 66  ? -35.87632 15.64287  6.46730   1.000 52.20371 ? 184 ILE B CB    1 
ATOM   460  C CG1   . ILE A 1 66  ? -35.59136 17.10198  6.80706   1.000 56.71124 ? 184 ILE B CG1   1 
ATOM   461  C CG2   . ILE A 1 66  ? -37.37948 15.34707  6.38570   1.000 51.58551 ? 184 ILE B CG2   1 
ATOM   462  C CD1   . ILE A 1 66  ? -36.17296 18.05891  5.79103   1.000 57.65249 ? 184 ILE B CD1   1 
ATOM   463  N N     . GLN A 1 67  ? -35.21037 12.72117  6.05169   1.000 49.10545 ? 185 GLN B N     1 
ATOM   464  C CA    . GLN A 1 67  ? -35.59823 11.36890  5.66137   1.000 48.13313 ? 185 GLN B CA    1 
ATOM   465  C C     . GLN A 1 67  ? -35.21012 10.35096  6.71926   1.000 49.69186 ? 185 GLN B C     1 
ATOM   466  O O     . GLN A 1 67  ? -35.93191 9.36956   6.93850   1.000 47.11718 ? 185 GLN B O     1 
ATOM   467  C CB    . GLN A 1 67  ? -34.95672 11.02942  4.31042   1.000 46.95657 ? 185 GLN B CB    1 
ATOM   468  C CG    . GLN A 1 67  ? -35.60089 9.85735   3.58141   1.000 45.27341 ? 185 GLN B CG    1 
ATOM   469  C CD    . GLN A 1 67  ? -36.98994 10.18173  3.05962   1.000 45.29077 ? 185 GLN B CD    1 
ATOM   470  O OE1   . GLN A 1 67  ? -37.30601 11.33329  2.76565   1.000 44.75134 ? 185 GLN B OE1   1 
ATOM   471  N NE2   . GLN A 1 67  ? -37.82705 9.15624   2.93941   1.000 45.29011 ? 185 GLN B NE2   1 
ATOM   472  N N     . SER A 1 68  ? -34.08099 10.58127  7.39331   1.000 50.68196 ? 186 SER B N     1 
ATOM   473  C CA    . SER A 1 68  ? -33.60878 9.67162   8.42803   1.000 53.89876 ? 186 SER B CA    1 
ATOM   474  C C     . SER A 1 68  ? -34.63273 9.48666   9.53667   1.000 55.84740 ? 186 SER B C     1 
ATOM   475  O O     . SER A 1 68  ? -34.71110 8.40676   10.13359  1.000 59.59884 ? 186 SER B O     1 
ATOM   476  C CB    . SER A 1 68  ? -32.30525 10.19898  9.01550   1.000 55.42255 ? 186 SER B CB    1 
ATOM   477  O OG    . SER A 1 68  ? -31.19637 9.61445   8.35090   1.000 59.98675 ? 186 SER B OG    1 
ATOM   478  N N     . HIS A 1 69  ? -35.41611 10.51915  9.83474   1.000 57.42684 ? 187 HIS B N     1 
ATOM   479  C CA    . HIS A 1 69  ? -36.35020 10.46664  10.94683  1.000 58.31022 ? 187 HIS B CA    1 
ATOM   480  C C     . HIS A 1 69  ? -37.78652 10.26902  10.49010  1.000 58.19256 ? 187 HIS B C     1 
ATOM   481  O O     . HIS A 1 69  ? -38.70418 10.31606  11.31426  1.000 58.69290 ? 187 HIS B O     1 
ATOM   482  C CB    . HIS A 1 69  ? -36.21223 11.72986  11.79711  1.000 60.92213 ? 187 HIS B CB    1 
ATOM   483  C CG    . HIS A 1 69  ? -34.88207 11.84647  12.48043  1.000 63.46932 ? 187 HIS B CG    1 
ATOM   484  N ND1   . HIS A 1 69  ? -34.40678 10.89059  13.35307  1.000 65.55039 ? 187 HIS B ND1   1 
ATOM   485  C CD2   . HIS A 1 69  ? -33.91937 12.79732  12.40485  1.000 66.86984 ? 187 HIS B CD2   1 
ATOM   486  C CE1   . HIS A 1 69  ? -33.21361 11.25188  13.79299  1.000 65.72078 ? 187 HIS B CE1   1 
ATOM   487  N NE2   . HIS A 1 69  ? -32.89545 12.40587  13.23390  1.000 68.52153 ? 187 HIS B NE2   1 
ATOM   488  N N     . LEU A 1 70  ? -38.00166 10.02968  9.20221   1.000 53.34368 ? 188 LEU B N     1 
ATOM   489  C CA    . LEU A 1 70  ? -39.32268 9.68851   8.69790   1.000 52.06146 ? 188 LEU B CA    1 
ATOM   490  C C     . LEU A 1 70  ? -39.47463 8.17482   8.79206   1.000 52.57144 ? 188 LEU B C     1 
ATOM   491  O O     . LEU A 1 70  ? -38.66749 7.43558   8.21996   1.000 54.91870 ? 188 LEU B O     1 
ATOM   492  C CB    . LEU A 1 70  ? -39.47537 10.16072  7.25275   1.000 49.22082 ? 188 LEU B CB    1 
ATOM   493  C CG    . LEU A 1 70  ? -39.73050 11.64421  7.03257   1.000 47.19970 ? 188 LEU B CG    1 
ATOM   494  C CD1   . LEU A 1 70  ? -39.82144 11.94942  5.55047   1.000 49.29962 ? 188 LEU B CD1   1 
ATOM   495  C CD2   . LEU A 1 70  ? -40.97766 12.08568  7.76765   1.000 48.10957 ? 188 LEU B CD2   1 
ATOM   496  N N     . ARG A 1 71  ? -40.48125 7.70470   9.52419   1.000 48.00068 ? 189 ARG B N     1 
ATOM   497  C CA    . ARG A 1 71  ? -40.75845 6.27044   9.57222   1.000 51.27572 ? 189 ARG B CA    1 
ATOM   498  C C     . ARG A 1 71  ? -42.26235 6.07361   9.45130   1.000 51.03185 ? 189 ARG B C     1 
ATOM   499  O O     . ARG A 1 71  ? -43.01292 6.38451   10.38081  1.000 46.23168 ? 189 ARG B O     1 
ATOM   500  C CB    . ARG A 1 71  ? -40.21097 5.63877   10.85528  1.000 54.07596 ? 189 ARG B CB    1 
ATOM   501  N N     . HIS A 1 72  ? -42.70375 5.56522   8.30156   1.000 48.17779 ? 190 HIS B N     1 
ATOM   502  C CA    . HIS A 1 72  ? -44.11656 5.39135   8.03203   1.000 45.65183 ? 190 HIS B CA    1 
ATOM   503  C C     . HIS A 1 72  ? -44.24934 4.24657   7.04135   1.000 45.40008 ? 190 HIS B C     1 
ATOM   504  O O     . HIS A 1 72  ? -43.44479 4.16029   6.10235   1.000 44.85001 ? 190 HIS B O     1 
ATOM   505  C CB    . HIS A 1 72  ? -44.74049 6.67631   7.45573   1.000 45.66771 ? 190 HIS B CB    1 
ATOM   506  C CG    . HIS A 1 72  ? -46.23199 6.66862   7.42328   1.000 43.93402 ? 190 HIS B CG    1 
ATOM   507  N ND1   . HIS A 1 72  ? -46.94652 5.98010   6.46710   1.000 46.05365 ? 190 HIS B ND1   1 
ATOM   508  C CD2   . HIS A 1 72  ? -47.14963 7.25990   8.22903   1.000 41.24908 ? 190 HIS B CD2   1 
ATOM   509  C CE1   . HIS A 1 72  ? -48.23826 6.14025   6.69091   1.000 45.90048 ? 190 HIS B CE1   1 
ATOM   510  N NE2   . HIS A 1 72  ? -48.38754 6.91347   7.75375   1.000 43.52905 ? 190 HIS B NE2   1 
ATOM   511  N N     . PRO A 1 73  ? -45.23296 3.36179   7.21579   1.000 44.86053 ? 191 PRO B N     1 
ATOM   512  C CA    . PRO A 1 73  ? -45.41448 2.26363   6.24826   1.000 43.78048 ? 191 PRO B CA    1 
ATOM   513  C C     . PRO A 1 73  ? -45.52700 2.72058   4.80162   1.000 46.34525 ? 191 PRO B C     1 
ATOM   514  O O     . PRO A 1 73  ? -45.17124 1.95417   3.89723   1.000 44.82260 ? 191 PRO B O     1 
ATOM   515  C CB    . PRO A 1 73  ? -46.71175 1.59184   6.72158   1.000 47.42215 ? 191 PRO B CB    1 
ATOM   516  C CG    . PRO A 1 73  ? -47.39382 2.61835   7.58123   1.000 49.76578 ? 191 PRO B CG    1 
ATOM   517  C CD    . PRO A 1 73  ? -46.27347 3.36344   8.25356   1.000 47.39637 ? 191 PRO B CD    1 
ATOM   518  N N     . ASN A 1 74  ? -45.99644 3.94931   4.54650   1.000 44.35758 ? 192 ASN B N     1 
ATOM   519  C CA    . ASN A 1 74  ? -46.20877 4.43436   3.18483   1.000 41.94775 ? 192 ASN B CA    1 
ATOM   520  C C     . ASN A 1 74  ? -45.18842 5.48679   2.76271   1.000 43.67729 ? 192 ASN B C     1 
ATOM   521  O O     . ASN A 1 74  ? -45.47143 6.30634   1.87981   1.000 36.76178 ? 192 ASN B O     1 
ATOM   522  C CB    . ASN A 1 74  ? -47.62439 4.97939   3.03539   1.000 43.68080 ? 192 ASN B CB    1 
ATOM   523  C CG    . ASN A 1 74  ? -48.67918 3.92954   3.33212   1.000 45.72527 ? 192 ASN B CG    1 
ATOM   524  O OD1   . ASN A 1 74  ? -49.37500 4.01340   4.34250   1.000 45.73869 ? 192 ASN B OD1   1 
ATOM   525  N ND2   . ASN A 1 74  ? -48.79432 2.92469   2.45935   1.000 44.72603 ? 192 ASN B ND2   1 
ATOM   526  N N     . ILE A 1 75  ? -44.00915 5.48503   3.37568   1.000 39.11485 ? 193 ILE B N     1 
ATOM   527  C CA    . ILE A 1 75  ? -42.88798 6.31978   2.96178   1.000 42.57024 ? 193 ILE B CA    1 
ATOM   528  C C     . ILE A 1 75  ? -41.66311 5.42200   2.85550   1.000 42.36023 ? 193 ILE B C     1 
ATOM   529  O O     . ILE A 1 75  ? -41.36680 4.66002   3.78463   1.000 44.46351 ? 193 ILE B O     1 
ATOM   530  C CB    . ILE A 1 75  ? -42.63256 7.48216   3.94052   1.000 41.19997 ? 193 ILE B CB    1 
ATOM   531  C CG1   . ILE A 1 75  ? -43.84656 8.41784   3.99298   1.000 40.48633 ? 193 ILE B CG1   1 
ATOM   532  C CG2   . ILE A 1 75  ? -41.37129 8.28628   3.53719   1.000 42.81033 ? 193 ILE B CG2   1 
ATOM   533  C CD1   . ILE A 1 75  ? -43.70911 9.47738   5.06673   1.000 43.31023 ? 193 ILE B CD1   1 
ATOM   534  N N     . LEU A 1 76  ? -40.97412 5.48615   1.71280   1.000 41.74629 ? 194 LEU B N     1 
ATOM   535  C CA    . LEU A 1 76  ? -39.80677 4.63674   1.49879   1.000 41.41243 ? 194 LEU B CA    1 
ATOM   536  C C     . LEU A 1 76  ? -38.71849 4.96485   2.51691   1.000 41.19902 ? 194 LEU B C     1 
ATOM   537  O O     . LEU A 1 76  ? -38.34937 6.12953   2.70248   1.000 41.12711 ? 194 LEU B O     1 
ATOM   538  C CB    . LEU A 1 76  ? -39.28388 4.82115   0.07506   1.000 39.96928 ? 194 LEU B CB    1 
ATOM   539  C CG    . LEU A 1 76  ? -38.37601 3.71312   -0.45742  1.000 39.42668 ? 194 LEU B CG    1 
ATOM   540  C CD1   . LEU A 1 76  ? -39.13517 2.43883   -0.77702  1.000 40.70042 ? 194 LEU B CD1   1 
ATOM   541  C CD2   . LEU A 1 76  ? -37.59200 4.23425   -1.68114  1.000 38.70177 ? 194 LEU B CD2   1 
ATOM   542  N N     . ARG A 1 77  ? -38.19046 3.94318   3.18397   1.000 40.58325 ? 195 ARG B N     1 
ATOM   543  C CA    . ARG A 1 77  ? -37.27837 4.23409   4.27356   1.000 42.66662 ? 195 ARG B CA    1 
ATOM   544  C C     . ARG A 1 77  ? -35.85982 4.39696   3.74447   1.000 43.70369 ? 195 ARG B C     1 
ATOM   545  O O     . ARG A 1 77  ? -35.45565 3.74189   2.77611   1.000 41.22969 ? 195 ARG B O     1 
ATOM   546  C CB    . ARG A 1 77  ? -37.33888 3.16740   5.37389   1.000 46.74759 ? 195 ARG B CB    1 
ATOM   547  C CG    . ARG A 1 77  ? -36.33482 3.50897   6.47523   1.000 56.07671 ? 195 ARG B CG    1 
ATOM   548  C CD    . ARG A 1 77  ? -37.07038 3.82078   7.78799   1.000 60.41087 ? 195 ARG B CD    1 
ATOM   549  N NE    . ARG A 1 77  ? -36.23067 3.77553   8.98089   1.000 68.71595 ? 195 ARG B NE    1 
ATOM   550  C CZ    . ARG A 1 77  ? -36.63799 3.35777   10.17301  1.000 76.98395 ? 195 ARG B CZ    1 
ATOM   551  N NH1   . ARG A 1 77  ? -37.88956 2.97624   10.38446  1.000 74.60600 ? 195 ARG B NH1   1 
ATOM   552  N NH2   . ARG A 1 77  ? -35.78021 3.36762   11.18932  1.000 80.07134 ? 195 ARG B NH2   1 
ATOM   553  N N     . LEU A 1 78  ? -35.14486 5.33775   4.33528   1.000 39.40122 ? 196 LEU B N     1 
ATOM   554  C CA    . LEU A 1 78  ? -33.70839 5.47620   4.14449   1.000 41.76788 ? 196 LEU B CA    1 
ATOM   555  C C     . LEU A 1 78  ? -33.00081 4.69985   5.25150   1.000 48.49523 ? 196 LEU B C     1 
ATOM   556  O O     . LEU A 1 78  ? -33.18075 5.00426   6.43680   1.000 47.80054 ? 196 LEU B O     1 
ATOM   557  C CB    . LEU A 1 78  ? -33.31479 6.94562   4.19007   1.000 40.95407 ? 196 LEU B CB    1 
ATOM   558  C CG    . LEU A 1 78  ? -31.82066 7.23864   4.20899   1.000 42.90962 ? 196 LEU B CG    1 
ATOM   559  C CD1   . LEU A 1 78  ? -31.15496 6.69544   2.93353   1.000 40.74782 ? 196 LEU B CD1   1 
ATOM   560  C CD2   . LEU A 1 78  ? -31.55932 8.72644   4.37691   1.000 45.64494 ? 196 LEU B CD2   1 
ATOM   561  N N     . TYR A 1 79  ? -32.20900 3.68963   4.87911   1.000 45.55896 ? 197 TYR B N     1 
ATOM   562  C CA    . TYR A 1 79  ? -31.59975 2.84625   5.90551   1.000 46.23747 ? 197 TYR B CA    1 
ATOM   563  C C     . TYR A 1 79  ? -30.29730 3.45163   6.40450   1.000 47.05612 ? 197 TYR B C     1 
ATOM   564  O O     . TYR A 1 79  ? -29.98276 3.37057   7.59700   1.000 49.56183 ? 197 TYR B O     1 
ATOM   565  C CB    . TYR A 1 79  ? -31.36754 1.44165   5.35571   1.000 43.49752 ? 197 TYR B CB    1 
ATOM   566  C CG    . TYR A 1 79  ? -32.64280 0.65137   5.28546   1.000 46.43136 ? 197 TYR B CG    1 
ATOM   567  C CD1   . TYR A 1 79  ? -33.47323 0.54140   6.39525   1.000 49.15605 ? 197 TYR B CD1   1 
ATOM   568  C CD2   . TYR A 1 79  ? -33.02473 0.01472   4.10837   1.000 49.24265 ? 197 TYR B CD2   1 
ATOM   569  C CE1   . TYR A 1 79  ? -34.65615 -0.15394  6.33635   1.000 51.90282 ? 197 TYR B CE1   1 
ATOM   570  C CE2   . TYR A 1 79  ? -34.21305 -0.71326  4.04166   1.000 45.99750 ? 197 TYR B CE2   1 
ATOM   571  C CZ    . TYR A 1 79  ? -35.01368 -0.79570  5.16277   1.000 53.46753 ? 197 TYR B CZ    1 
ATOM   572  O OH    . TYR A 1 79  ? -36.19316 -1.51730  5.11898   1.000 62.68217 ? 197 TYR B OH    1 
ATOM   573  N N     . GLY A 1 80  ? -29.54018 4.06337   5.50792   1.000 43.74533 ? 198 GLY B N     1 
ATOM   574  C CA    . GLY A 1 80  ? -28.29776 4.70726   5.86757   1.000 46.55924 ? 198 GLY B CA    1 
ATOM   575  C C     . GLY A 1 80  ? -27.70067 5.33732   4.63994   1.000 47.44129 ? 198 GLY B C     1 
ATOM   576  O O     . GLY A 1 80  ? -28.28605 5.29590   3.55991   1.000 45.45106 ? 198 GLY B O     1 
ATOM   577  N N     . TYR A 1 81  ? -26.51703 5.91163   4.80840   1.000 46.20054 ? 199 TYR B N     1 
ATOM   578  C CA    . TYR A 1 81  ? -25.86533 6.58548   3.69440   1.000 44.84586 ? 199 TYR B CA    1 
ATOM   579  C C     . TYR A 1 81  ? -24.36861 6.67421   3.95852   1.000 49.86369 ? 199 TYR B C     1 
ATOM   580  O O     . TYR A 1 81  ? -23.90505 6.49618   5.08971   1.000 49.09655 ? 199 TYR B O     1 
ATOM   581  C CB    . TYR A 1 81  ? -26.45785 7.97734   3.48108   1.000 48.46025 ? 199 TYR B CB    1 
ATOM   582  C CG    . TYR A 1 81  ? -26.36011 8.84469   4.71192   1.000 52.18958 ? 199 TYR B CG    1 
ATOM   583  C CD1   . TYR A 1 81  ? -27.28354 8.72143   5.74727   1.000 52.64019 ? 199 TYR B CD1   1 
ATOM   584  C CD2   . TYR A 1 81  ? -25.35218 9.79417   4.83550   1.000 54.33307 ? 199 TYR B CD2   1 
ATOM   585  C CE1   . TYR A 1 81  ? -27.19041 9.51215   6.87729   1.000 55.77175 ? 199 TYR B CE1   1 
ATOM   586  C CE2   . TYR A 1 81  ? -25.25842 10.59431  5.95653   1.000 57.87714 ? 199 TYR B CE2   1 
ATOM   587  C CZ    . TYR A 1 81  ? -26.17667 10.45172  6.97237   1.000 59.09330 ? 199 TYR B CZ    1 
ATOM   588  O OH    . TYR A 1 81  ? -26.08433 11.25119  8.08940   1.000 65.56723 ? 199 TYR B OH    1 
ATOM   589  N N     . PHE A 1 82  ? -23.62016 6.94531   2.89507   1.000 44.30677 ? 200 PHE B N     1 
ATOM   590  C CA    . PHE A 1 82  ? -22.17642 7.11339   2.97934   1.000 47.59440 ? 200 PHE B CA    1 
ATOM   591  C C     . PHE A 1 82  ? -21.71700 7.83300   1.71884   1.000 50.32340 ? 200 PHE B C     1 
ATOM   592  O O     . PHE A 1 82  ? -22.51791 8.16401   0.84079   1.000 45.70955 ? 200 PHE B O     1 
ATOM   593  C CB    . PHE A 1 82  ? -21.45409 5.76660   3.18331   1.000 49.96952 ? 200 PHE B CB    1 
ATOM   594  C CG    . PHE A 1 82  ? -21.74430 4.70979   2.12219   1.000 48.27477 ? 200 PHE B CG    1 
ATOM   595  C CD1   . PHE A 1 82  ? -22.88673 3.91810   2.18977   1.000 46.31311 ? 200 PHE B CD1   1 
ATOM   596  C CD2   . PHE A 1 82  ? -20.83637 4.47616   1.08988   1.000 47.69591 ? 200 PHE B CD2   1 
ATOM   597  C CE1   . PHE A 1 82  ? -23.13143 2.93326   1.23524   1.000 46.54379 ? 200 PHE B CE1   1 
ATOM   598  C CE2   . PHE A 1 82  ? -21.07114 3.49298   0.12849   1.000 48.29112 ? 200 PHE B CE2   1 
ATOM   599  C CZ    . PHE A 1 82  ? -22.22617 2.72243   0.19738   1.000 46.44901 ? 200 PHE B CZ    1 
ATOM   600  N N     . HIS A 1 83  ? -20.41629 8.09260   1.63735   1.000 49.66707 ? 201 HIS B N     1 
ATOM   601  C CA    . HIS A 1 83  ? -19.87677 8.80926   0.49305   1.000 49.76027 ? 201 HIS B CA    1 
ATOM   602  C C     . HIS A 1 83  ? -18.46348 8.33100   0.22385   1.000 53.90674 ? 201 HIS B C     1 
ATOM   603  O O     . HIS A 1 83  ? -17.83862 7.67065   1.05639   1.000 54.55281 ? 201 HIS B O     1 
ATOM   604  C CB    . HIS A 1 83  ? -19.87266 10.32550  0.72145   1.000 52.10998 ? 201 HIS B CB    1 
ATOM   605  C CG    . HIS A 1 83  ? -19.02568 10.75251  1.88295   1.000 54.22272 ? 201 HIS B CG    1 
ATOM   606  N ND1   . HIS A 1 83  ? -17.66684 10.95726  1.77934   1.000 58.34537 ? 201 HIS B ND1   1 
ATOM   607  C CD2   . HIS A 1 83  ? -19.34461 10.99542  3.17737   1.000 54.17483 ? 201 HIS B CD2   1 
ATOM   608  C CE1   . HIS A 1 83  ? -17.18604 11.31534  2.95714   1.000 54.48567 ? 201 HIS B CE1   1 
ATOM   609  N NE2   . HIS A 1 83  ? -18.18352 11.34712  3.82188   1.000 54.08562 ? 201 HIS B NE2   1 
ATOM   610  N N     . ASP A 1 84  ? -17.97410 8.65506   -0.96635  1.000 53.97183 ? 202 ASP B N     1 
ATOM   611  C CA    . ASP A 1 84  ? -16.55013 8.56113   -1.26169  1.000 56.56354 ? 202 ASP B CA    1 
ATOM   612  C C     . ASP A 1 84  ? -16.16172 9.89818   -1.88616  1.000 54.21103 ? 202 ASP B C     1 
ATOM   613  O O     . ASP A 1 84  ? -16.81912 10.92673  -1.67398  1.000 53.94669 ? 202 ASP B O     1 
ATOM   614  C CB    . ASP A 1 84  ? -16.22506 7.31609   -2.10978  1.000 53.28124 ? 202 ASP B CB    1 
ATOM   615  C CG    . ASP A 1 84  ? -16.89385 7.32375   -3.47799  1.000 53.82485 ? 202 ASP B CG    1 
ATOM   616  O OD1   . ASP A 1 84  ? -17.31111 8.39427   -3.96217  1.000 53.81670 ? 202 ASP B OD1   1 
ATOM   617  O OD2   . ASP A 1 84  ? -17.02861 6.22877   -4.06118  1.000 52.79947 ? 202 ASP B OD2   1 
ATOM   618  N N     . ALA A 1 85  ? -15.08792 9.89194   -2.67642  1.000 56.08254 ? 203 ALA B N     1 
ATOM   619  C CA    . ALA A 1 85  ? -14.55034 11.14491  -3.19831  1.000 57.87534 ? 203 ALA B CA    1 
ATOM   620  C C     . ALA A 1 85  ? -15.44205 11.74668  -4.27380  1.000 58.65388 ? 203 ALA B C     1 
ATOM   621  O O     . ALA A 1 85  ? -15.41652 12.96480  -4.48400  1.000 59.54685 ? 203 ALA B O     1 
ATOM   622  C CB    . ALA A 1 85  ? -13.13985 10.92761  -3.74906  1.000 58.13059 ? 203 ALA B CB    1 
ATOM   623  N N     . THR A 1 86  ? -16.23881 10.92473  -4.95647  1.000 57.81975 ? 204 THR B N     1 
ATOM   624  C CA    . THR A 1 86  ? -17.00381 11.38288  -6.10587  1.000 56.80200 ? 204 THR B CA    1 
ATOM   625  C C     . THR A 1 86  ? -18.50631 11.15194  -5.99285  1.000 55.08032 ? 204 THR B C     1 
ATOM   626  O O     . THR A 1 86  ? -19.25791 11.70292  -6.80716  1.000 52.44313 ? 204 THR B O     1 
ATOM   627  C CB    . THR A 1 86  ? -16.49526 10.69716  -7.38515  1.000 55.59699 ? 204 THR B CB    1 
ATOM   628  O OG1   . THR A 1 86  ? -16.71630 9.28658   -7.28760  1.000 58.10742 ? 204 THR B OG1   1 
ATOM   629  C CG2   . THR A 1 86  ? -14.99701 10.94514  -7.56905  1.000 59.20683 ? 204 THR B CG2   1 
ATOM   630  N N     . ARG A 1 87  ? -18.96763 10.37414  -5.01643  1.000 50.18659 ? 205 ARG B N     1 
ATOM   631  C CA    . ARG A 1 87  ? -20.34449 9.90235   -5.00137  1.000 50.09256 ? 205 ARG B CA    1 
ATOM   632  C C     . ARG A 1 87  ? -20.92820 9.97261   -3.59879  1.000 49.16108 ? 205 ARG B C     1 
ATOM   633  O O     . ARG A 1 87  ? -20.21357 9.87702   -2.59743  1.000 50.71542 ? 205 ARG B O     1 
ATOM   634  C CB    . ARG A 1 87  ? -20.42193 8.46498   -5.54235  1.000 50.76352 ? 205 ARG B CB    1 
ATOM   635  C CG    . ARG A 1 87  ? -19.81387 8.28253   -6.93949  1.000 53.63263 ? 205 ARG B CG    1 
ATOM   636  C CD    . ARG A 1 87  ? -20.02052 6.87616   -7.46928  1.000 56.53132 ? 205 ARG B CD    1 
ATOM   637  N NE    . ARG A 1 87  ? -18.88492 6.35877   -8.23128  1.000 67.33727 ? 205 ARG B NE    1 
ATOM   638  C CZ    . ARG A 1 87  ? -17.65069 6.18584   -7.76758  1.000 66.78751 ? 205 ARG B CZ    1 
ATOM   639  N NH1   . ARG A 1 87  ? -17.31915 6.50287   -6.52431  1.000 65.83249 ? 205 ARG B NH1   1 
ATOM   640  N NH2   . ARG A 1 87  ? -16.71964 5.68561   -8.57617  1.000 69.02627 ? 205 ARG B NH2   1 
ATOM   641  N N     . VAL A 1 88  ? -22.24678 10.14378  -3.53994  1.000 45.52409 ? 206 VAL B N     1 
ATOM   642  C CA    . VAL A 1 88  ? -23.02117 9.99073   -2.31279  1.000 44.37661 ? 206 VAL B CA    1 
ATOM   643  C C     . VAL A 1 88  ? -23.91450 8.77276   -2.51817  1.000 43.19044 ? 206 VAL B C     1 
ATOM   644  O O     . VAL A 1 88  ? -24.55294 8.64398   -3.56947  1.000 41.08232 ? 206 VAL B O     1 
ATOM   645  C CB    . VAL A 1 88  ? -23.84211 11.25568  -1.99648  1.000 46.68348 ? 206 VAL B CB    1 
ATOM   646  C CG1   . VAL A 1 88  ? -24.77212 11.02132  -0.81529  1.000 43.48283 ? 206 VAL B CG1   1 
ATOM   647  C CG2   . VAL A 1 88  ? -22.92223 12.45990  -1.73364  1.000 47.69285 ? 206 VAL B CG2   1 
ATOM   648  N N     . TYR A 1 89  ? -23.91101 7.85164   -1.55175  1.000 41.66851 ? 207 TYR B N     1 
ATOM   649  C CA    . TYR A 1 89  ? -24.67622 6.60788   -1.63396  1.000 41.72398 ? 207 TYR B CA    1 
ATOM   650  C C     . TYR A 1 89  ? -25.81565 6.64228   -0.62643  1.000 45.17910 ? 207 TYR B C     1 
ATOM   651  O O     . TYR A 1 89  ? -25.57898 6.79844   0.58142   1.000 43.64821 ? 207 TYR B O     1 
ATOM   652  C CB    . TYR A 1 89  ? -23.79760 5.38142   -1.36645  1.000 43.68439 ? 207 TYR B CB    1 
ATOM   653  C CG    . TYR A 1 89  ? -22.61350 5.26472   -2.29106  1.000 42.20196 ? 207 TYR B CG    1 
ATOM   654  C CD1   . TYR A 1 89  ? -21.43871 5.96813   -2.04268  1.000 45.43827 ? 207 TYR B CD1   1 
ATOM   655  C CD2   . TYR A 1 89  ? -22.67636 4.47311   -3.42797  1.000 43.26394 ? 207 TYR B CD2   1 
ATOM   656  C CE1   . TYR A 1 89  ? -20.35240 5.87186   -2.89972  1.000 46.97318 ? 207 TYR B CE1   1 
ATOM   657  C CE2   . TYR A 1 89  ? -21.60447 4.37228   -4.29278  1.000 43.49822 ? 207 TYR B CE2   1 
ATOM   658  C CZ    . TYR A 1 89  ? -20.44432 5.07004   -4.02115  1.000 50.21785 ? 207 TYR B CZ    1 
ATOM   659  O OH    . TYR A 1 89  ? -19.37852 4.96852   -4.88839  1.000 50.11595 ? 207 TYR B OH    1 
ATOM   660  N N     . LEU A 1 90  ? -27.04311 6.46522   -1.11182  1.000 38.21736 ? 208 LEU B N     1 
ATOM   661  C CA    . LEU A 1 90  ? -28.20998 6.37673   -0.24625  1.000 38.11926 ? 208 LEU B CA    1 
ATOM   662  C C     . LEU A 1 90  ? -28.70889 4.93816   -0.25129  1.000 39.12533 ? 208 LEU B C     1 
ATOM   663  O O     . LEU A 1 90  ? -29.02158 4.39339   -1.31644  1.000 39.74570 ? 208 LEU B O     1 
ATOM   664  C CB    . LEU A 1 90  ? -29.31448 7.33513   -0.70025  1.000 35.64325 ? 208 LEU B CB    1 
ATOM   665  C CG    . LEU A 1 90  ? -28.86703 8.75665   -1.06051  1.000 42.85170 ? 208 LEU B CG    1 
ATOM   666  C CD1   . LEU A 1 90  ? -30.03437 9.48623   -1.68202  1.000 39.13058 ? 208 LEU B CD1   1 
ATOM   667  C CD2   . LEU A 1 90  ? -28.35652 9.52376   0.16335   1.000 43.34281 ? 208 LEU B CD2   1 
ATOM   668  N N     . ILE A 1 91  ? -28.78695 4.32835   0.93261   1.000 36.12016 ? 209 ILE B N     1 
ATOM   669  C CA    . ILE A 1 91  ? -29.19626 2.93095   1.06727   1.000 37.00312 ? 209 ILE B CA    1 
ATOM   670  C C     . ILE A 1 91  ? -30.69612 2.91599   1.33874   1.000 36.85878 ? 209 ILE B C     1 
ATOM   671  O O     . ILE A 1 91  ? -31.13397 3.15581   2.46546   1.000 38.40890 ? 209 ILE B O     1 
ATOM   672  C CB    . ILE A 1 91  ? -28.43197 2.20847   2.18208   1.000 41.18089 ? 209 ILE B CB    1 
ATOM   673  C CG1   . ILE A 1 91  ? -26.91198 2.38657   2.04385   1.000 42.63038 ? 209 ILE B CG1   1 
ATOM   674  C CG2   . ILE A 1 91  ? -28.78635 0.73693   2.17171   1.000 42.42102 ? 209 ILE B CG2   1 
ATOM   675  C CD1   . ILE A 1 91  ? -26.14860 2.15926   3.36179   1.000 47.71024 ? 209 ILE B CD1   1 
ATOM   676  N N     . LEU A 1 92  ? -31.49131 2.61354   0.31136   1.000 38.22576 ? 210 LEU B N     1 
ATOM   677  C CA    . LEU A 1 92  ? -32.93886 2.77476   0.37511   1.000 39.10618 ? 210 LEU B CA    1 
ATOM   678  C C     . LEU A 1 92  ? -33.65171 1.42835   0.45982   1.000 38.27422 ? 210 LEU B C     1 
ATOM   679  O O     . LEU A 1 92  ? -33.15986 0.41374   -0.03130  1.000 39.41465 ? 210 LEU B O     1 
ATOM   680  C CB    . LEU A 1 92  ? -33.44911 3.52105   -0.86254  1.000 37.25939 ? 210 LEU B CB    1 
ATOM   681  C CG    . LEU A 1 92  ? -32.85433 4.89879   -1.13134  1.000 39.74934 ? 210 LEU B CG    1 
ATOM   682  C CD1   . LEU A 1 92  ? -33.43812 5.48799   -2.40464  1.000 39.01983 ? 210 LEU B CD1   1 
ATOM   683  C CD2   . LEU A 1 92  ? -33.12525 5.79788   0.02804   1.000 44.38272 ? 210 LEU B CD2   1 
ATOM   684  N N     . GLU A 1 93  ? -34.83737 1.43501   1.06279   1.000 38.20055 ? 211 GLU B N     1 
ATOM   685  C CA    . GLU A 1 93  ? -35.74129 0.30137   0.94258   1.000 37.40851 ? 211 GLU B CA    1 
ATOM   686  C C     . GLU A 1 93  ? -36.03096 0.01890   -0.53249  1.000 39.66327 ? 211 GLU B C     1 
ATOM   687  O O     . GLU A 1 93  ? -36.27350 0.93594   -1.32513  1.000 35.06626 ? 211 GLU B O     1 
ATOM   688  C CB    . GLU A 1 93  ? -37.04458 0.60321   1.70064   1.000 40.37038 ? 211 GLU B CB    1 
ATOM   689  C CG    . GLU A 1 93  ? -38.11859 -0.46133  1.63638   1.000 41.46594 ? 211 GLU B CG    1 
ATOM   690  C CD    . GLU A 1 93  ? -39.41599 0.02437   2.27295   1.000 42.96653 ? 211 GLU B CD    1 
ATOM   691  O OE1   . GLU A 1 93  ? -39.43184 1.16868   2.75512   1.000 42.96359 ? 211 GLU B OE1   1 
ATOM   692  O OE2   . GLU A 1 93  ? -40.42428 -0.70927  2.25794   1.000 44.12953 ? 211 GLU B OE2   1 
ATOM   693  N N     . TYR A 1 94  ? -35.99087 -1.25848  -0.89702  1.000 37.02365 ? 212 TYR B N     1 
ATOM   694  C CA    . TYR A 1 94  ? -36.34544 -1.69886  -2.23509  1.000 41.88048 ? 212 TYR B CA    1 
ATOM   695  C C     . TYR A 1 94  ? -37.83152 -2.02029  -2.25198  1.000 41.32567 ? 212 TYR B C     1 
ATOM   696  O O     . TYR A 1 94  ? -38.32967 -2.75590  -1.39026  1.000 41.64306 ? 212 TYR B O     1 
ATOM   697  C CB    . TYR A 1 94  ? -35.49961 -2.91119  -2.63087  1.000 39.00833 ? 212 TYR B CB    1 
ATOM   698  C CG    . TYR A 1 94  ? -35.95677 -3.71081  -3.84148  1.000 38.84103 ? 212 TYR B CG    1 
ATOM   699  C CD1   . TYR A 1 94  ? -35.94749 -3.16775  -5.11749  1.000 39.95269 ? 212 TYR B CD1   1 
ATOM   700  C CD2   . TYR A 1 94  ? -36.34974 -5.03239  -3.69566  1.000 39.71247 ? 212 TYR B CD2   1 
ATOM   701  C CE1   . TYR A 1 94  ? -36.34623 -3.91737  -6.23106  1.000 41.49143 ? 212 TYR B CE1   1 
ATOM   702  C CE2   . TYR A 1 94  ? -36.74892 -5.78837  -4.78726  1.000 41.79134 ? 212 TYR B CE2   1 
ATOM   703  C CZ    . TYR A 1 94  ? -36.73686 -5.24047  -6.04523  1.000 41.59938 ? 212 TYR B CZ    1 
ATOM   704  O OH    . TYR A 1 94  ? -37.14814 -6.01821  -7.09602  1.000 44.43761 ? 212 TYR B OH    1 
ATOM   705  N N     . ALA A 1 95  ? -38.54458 -1.43001  -3.20343  1.000 39.10566 ? 213 ALA B N     1 
ATOM   706  C CA    . ALA A 1 95  ? -39.97189 -1.67014  -3.35628  1.000 41.39363 ? 213 ALA B CA    1 
ATOM   707  C C     . ALA A 1 95  ? -40.16619 -2.59440  -4.55257  1.000 42.40360 ? 213 ALA B C     1 
ATOM   708  O O     . ALA A 1 95  ? -40.04678 -2.14340  -5.70459  1.000 42.76358 ? 213 ALA B O     1 
ATOM   709  C CB    . ALA A 1 95  ? -40.72019 -0.34858  -3.55831  1.000 41.43935 ? 213 ALA B CB    1 
ATOM   710  N N     . PRO A 1 96  ? -40.46895 -3.88453  -4.34341  1.000 42.52976 ? 214 PRO B N     1 
ATOM   711  C CA    . PRO A 1 96  ? -40.28737 -4.88019  -5.42418  1.000 43.90770 ? 214 PRO B CA    1 
ATOM   712  C C     . PRO A 1 96  ? -41.22254 -4.72520  -6.61778  1.000 45.03122 ? 214 PRO B C     1 
ATOM   713  O O     . PRO A 1 96  ? -40.88781 -5.22121  -7.70413  1.000 43.78952 ? 214 PRO B O     1 
ATOM   714  C CB    . PRO A 1 96  ? -40.54792 -6.22628  -4.71886  1.000 43.36030 ? 214 PRO B CB    1 
ATOM   715  C CG    . PRO A 1 96  ? -40.44343 -5.92535  -3.24211  1.000 48.66825 ? 214 PRO B CG    1 
ATOM   716  C CD    . PRO A 1 96  ? -40.90719 -4.50243  -3.08221  1.000 42.69494 ? 214 PRO B CD    1 
ATOM   717  N N     . LEU A 1 97  ? -42.38090 -4.08991  -6.46975  1.000 44.48585 ? 215 LEU B N     1 
ATOM   718  C CA    . LEU A 1 97  ? -43.36359 -4.07904  -7.54940  1.000 45.80080 ? 215 LEU B CA    1 
ATOM   719  C C     . LEU A 1 97  ? -43.28379 -2.85174  -8.46803  1.000 46.04443 ? 215 LEU B C     1 
ATOM   720  O O     . LEU A 1 97  ? -44.17554 -2.66710  -9.31021  1.000 45.45678 ? 215 LEU B O     1 
ATOM   721  C CB    . LEU A 1 97  ? -44.77088 -4.21564  -6.97260  1.000 46.24531 ? 215 LEU B CB    1 
ATOM   722  C CG    . LEU A 1 97  ? -45.04133 -5.54167  -6.24947  1.000 48.30366 ? 215 LEU B CG    1 
ATOM   723  C CD1   . LEU A 1 97  ? -46.50022 -5.65311  -5.88426  1.000 50.74333 ? 215 LEU B CD1   1 
ATOM   724  C CD2   . LEU A 1 97  ? -44.59285 -6.71806  -7.08980  1.000 53.83558 ? 215 LEU B CD2   1 
ATOM   725  N N     . GLY A 1 98  ? -42.23758 -2.03360  -8.36073  1.000 43.35369 ? 216 GLY B N     1 
ATOM   726  C CA    . GLY A 1 98  ? -42.03537 -0.94766  -9.30406  1.000 42.95807 ? 216 GLY B CA    1 
ATOM   727  C C     . GLY A 1 98  ? -42.92027 0.25175   -9.00233  1.000 39.79285 ? 216 GLY B C     1 
ATOM   728  O O     . GLY A 1 98  ? -43.55030 0.33301   -7.94718  1.000 38.44708 ? 216 GLY B O     1 
ATOM   729  N N     . THR A 1 99  ? -42.99115 1.17862   -9.96785  1.000 37.84857 ? 217 THR B N     1 
ATOM   730  C CA    . THR A 1 99  ? -43.72927 2.41752   -9.75221  1.000 38.12907 ? 217 THR B CA    1 
ATOM   731  C C     . THR A 1 99  ? -45.22665 2.24523   -10.01261 1.000 37.69823 ? 217 THR B C     1 
ATOM   732  O O     . THR A 1 99  ? -45.67770 1.36872   -10.75738 1.000 35.95352 ? 217 THR B O     1 
ATOM   733  C CB    . THR A 1 99  ? -43.18026 3.54182   -10.63617 1.000 39.90730 ? 217 THR B CB    1 
ATOM   734  O OG1   . THR A 1 99  ? -43.43057 3.24273   -12.01742 1.000 37.16992 ? 217 THR B OG1   1 
ATOM   735  C CG2   . THR A 1 99  ? -41.68151 3.70276   -10.44450 1.000 38.24474 ? 217 THR B CG2   1 
ATOM   736  N N     . VAL A 1 100 ? -46.00899 3.12668   -9.38857  1.000 36.19936 ? 218 VAL B N     1 
ATOM   737  C CA    . VAL A 1 100 ? -47.42686 3.20833   -9.71194  1.000 37.41530 ? 218 VAL B CA    1 
ATOM   738  C C     . VAL A 1 100 ? -47.61100 3.66286   -11.15237 1.000 38.19931 ? 218 VAL B C     1 
ATOM   739  O O     . VAL A 1 100 ? -48.57236 3.25502   -11.82102 1.000 37.17173 ? 218 VAL B O     1 
ATOM   740  C CB    . VAL A 1 100 ? -48.14000 4.14452   -8.70805  1.000 39.95460 ? 218 VAL B CB    1 
ATOM   741  C CG1   . VAL A 1 100 ? -49.60585 4.31788   -9.08174  1.000 40.75740 ? 218 VAL B CG1   1 
ATOM   742  C CG2   . VAL A 1 100 ? -48.01742 3.56821   -7.29603  1.000 38.29177 ? 218 VAL B CG2   1 
ATOM   743  N N     . TYR A 1 101 ? -46.70582 4.51898   -11.64303 1.000 36.68269 ? 219 TYR B N     1 
ATOM   744  C CA    . TYR A 1 101 ? -46.73768 4.96698   -13.03899 1.000 39.47186 ? 219 TYR B CA    1 
ATOM   745  C C     . TYR A 1 101 ? -46.69719 3.77997   -14.00013 1.000 41.71755 ? 219 TYR B C     1 
ATOM   746  O O     . TYR A 1 101 ? -47.45909 3.72669   -14.97288 1.000 38.44053 ? 219 TYR B O     1 
ATOM   747  C CB    . TYR A 1 101 ? -45.56533 5.91863   -13.30832 1.000 36.09951 ? 219 TYR B CB    1 
ATOM   748  C CG    . TYR A 1 101 ? -45.31117 6.26442   -14.78045 1.000 40.03245 ? 219 TYR B CG    1 
ATOM   749  C CD1   . TYR A 1 101 ? -46.00986 7.30649   -15.41197 1.000 41.07881 ? 219 TYR B CD1   1 
ATOM   750  C CD2   . TYR A 1 101 ? -44.34740 5.58570   -15.52055 1.000 41.81965 ? 219 TYR B CD2   1 
ATOM   751  C CE1   . TYR A 1 101 ? -45.76663 7.64149   -16.75926 1.000 43.73519 ? 219 TYR B CE1   1 
ATOM   752  C CE2   . TYR A 1 101 ? -44.10507 5.90604   -16.86450 1.000 45.48981 ? 219 TYR B CE2   1 
ATOM   753  C CZ    . TYR A 1 101 ? -44.81472 6.93862   -17.47244 1.000 44.74138 ? 219 TYR B CZ    1 
ATOM   754  O OH    . TYR A 1 101 ? -44.56657 7.24467   -18.80615 1.000 45.31597 ? 219 TYR B OH    1 
ATOM   755  N N     . ARG A 1 102 ? -45.80041 2.82200   -13.75420 1.000 36.73909 ? 220 ARG B N     1 
ATOM   756  C CA    . ARG A 1 102 ? -45.73858 1.66311   -14.64180 1.000 40.92347 ? 220 ARG B CA    1 
ATOM   757  C C     . ARG A 1 102 ? -46.99367 0.81119   -14.52549 1.000 39.55857 ? 220 ARG B C     1 
ATOM   758  O O     . ARG A 1 102 ? -47.47475 0.27354   -15.53127 1.000 41.23953 ? 220 ARG B O     1 
ATOM   759  C CB    . ARG A 1 102 ? -44.50111 0.82373   -14.33492 1.000 44.61243 ? 220 ARG B CB    1 
ATOM   760  C CG    . ARG A 1 102 ? -44.53349 -0.55586  -14.97072 1.000 48.61452 ? 220 ARG B CG    1 
ATOM   761  C CD    . ARG A 1 102 ? -43.12719 -1.11989  -15.11772 1.000 54.49950 ? 220 ARG B CD    1 
ATOM   762  N NE    . ARG A 1 102 ? -43.11326 -2.57140  -15.25614 1.000 59.61814 ? 220 ARG B NE    1 
ATOM   763  C CZ    . ARG A 1 102 ? -43.35065 -3.44315  -14.28058 1.000 64.68895 ? 220 ARG B CZ    1 
ATOM   764  N NH1   . ARG A 1 102 ? -43.57915 -3.05376  -13.03210 1.000 58.62746 ? 220 ARG B NH1   1 
ATOM   765  N NH2   . ARG A 1 102 ? -43.33475 -4.74437  -14.55820 1.000 68.61547 ? 220 ARG B NH2   1 
ATOM   766  N N     . GLU A 1 103 ? -47.57044 0.71195   -13.32278 1.000 39.23423 ? 221 GLU B N     1 
ATOM   767  C CA    . GLU A 1 103 ? -48.79891 -0.05962  -13.18675 1.000 41.34273 ? 221 GLU B CA    1 
ATOM   768  C C     . GLU A 1 103 ? -49.95847 0.63392   -13.89993 1.000 44.38023 ? 221 GLU B C     1 
ATOM   769  O O     . GLU A 1 103 ? -50.87267 -0.03785  -14.40502 1.000 43.21536 ? 221 GLU B O     1 
ATOM   770  C CB    . GLU A 1 103 ? -49.10530 -0.29925  -11.69887 1.000 40.58397 ? 221 GLU B CB    1 
ATOM   771  C CG    . GLU A 1 103 ? -50.50242 -0.80090  -11.43724 1.000 44.06987 ? 221 GLU B CG    1 
ATOM   772  C CD    . GLU A 1 103 ? -50.88033 -0.83475  -9.96944  1.000 49.89182 ? 221 GLU B CD    1 
ATOM   773  O OE1   . GLU A 1 103 ? -50.82600 0.20934   -9.28381  1.000 47.41227 ? 221 GLU B OE1   1 
ATOM   774  O OE2   . GLU A 1 103 ? -51.24830 -1.92756  -9.48989  1.000 54.35790 ? 221 GLU B OE2   1 
ATOM   775  N N     . LEU A 1 104 ? -49.92004 1.97529   -13.97957 1.000 39.83355 ? 222 LEU B N     1 
ATOM   776  C CA    . LEU A 1 104 ? -50.88759 2.71882   -14.79132 1.000 38.67506 ? 222 LEU B CA    1 
ATOM   777  C C     . LEU A 1 104 ? -50.64859 2.49785   -16.28572 1.000 41.63377 ? 222 LEU B C     1 
ATOM   778  O O     . LEU A 1 104 ? -51.60728 2.39694   -17.05938 1.000 43.53913 ? 222 LEU B O     1 
ATOM   779  C CB    . LEU A 1 104 ? -50.81869 4.21699   -14.44956 1.000 39.03852 ? 222 LEU B CB    1 
ATOM   780  C CG    . LEU A 1 104 ? -52.04049 5.10231   -14.70206 1.000 42.67202 ? 222 LEU B CG    1 
ATOM   781  C CD1   . LEU A 1 104 ? -53.27815 4.64062   -13.95710 1.000 37.63929 ? 222 LEU B CD1   1 
ATOM   782  C CD2   . LEU A 1 104 ? -51.74734 6.56142   -14.33870 1.000 41.06790 ? 222 LEU B CD2   1 
ATOM   783  N N     . GLN A 1 105 ? -49.38086 2.41405   -16.71467 1.000 39.27317 ? 223 GLN B N     1 
ATOM   784  C CA    . GLN A 1 105 ? -49.08989 2.08590   -18.11339 1.000 42.71980 ? 223 GLN B CA    1 
ATOM   785  C C     . GLN A 1 105 ? -49.71296 0.74527   -18.48966 1.000 45.90343 ? 223 GLN B C     1 
ATOM   786  O O     . GLN A 1 105 ? -50.24139 0.57562   -19.59592 1.000 45.30652 ? 223 GLN B O     1 
ATOM   787  C CB    . GLN A 1 105 ? -47.57455 2.01076   -18.34783 1.000 46.30405 ? 223 GLN B CB    1 
ATOM   788  C CG    . GLN A 1 105 ? -46.76701 3.30808   -18.32542 1.000 47.68679 ? 223 GLN B CG    1 
ATOM   789  C CD    . GLN A 1 105 ? -45.27276 3.03688   -18.54709 1.000 49.08709 ? 223 GLN B CD    1 
ATOM   790  O OE1   . GLN A 1 105 ? -44.65426 2.27787   -17.79074 1.000 46.06188 ? 223 GLN B OE1   1 
ATOM   791  N NE2   . GLN A 1 105 ? -44.69025 3.65588   -19.57795 1.000 47.99561 ? 223 GLN B NE2   1 
ATOM   792  N N     . LYS A 1 106 ? -49.65929 -0.21594  -17.57141 1.000 40.88847 ? 224 LYS B N     1 
ATOM   793  C CA    . LYS A 1 106 ? -50.14937 -1.56697  -17.82288 1.000 47.67507 ? 224 LYS B CA    1 
ATOM   794  C C     . LYS A 1 106 ? -51.67098 -1.64410  -17.80021 1.000 48.79983 ? 224 LYS B C     1 
ATOM   795  O O     . LYS A 1 106 ? -52.27667 -2.30724  -18.65183 1.000 47.47539 ? 224 LYS B O     1 
ATOM   796  C CB    . LYS A 1 106 ? -49.56461 -2.52305  -16.78476 1.000 45.87010 ? 224 LYS B CB    1 
ATOM   797  C CG    . LYS A 1 106 ? -48.06744 -2.77061  -16.94946 1.000 52.50157 ? 224 LYS B CG    1 
ATOM   798  C CD    . LYS A 1 106 ? -47.49329 -3.46983  -15.72156 1.000 55.56016 ? 224 LYS B CD    1 
ATOM   799  C CE    . LYS A 1 106 ? -46.25894 -4.26608  -16.08946 1.000 60.27365 ? 224 LYS B CE    1 
ATOM   800  N NZ    . LYS A 1 106 ? -45.63311 -3.73509  -17.33371 1.000 64.23119 ? 224 LYS B NZ    1 
ATOM   801  N N     . LEU A 1 107 ? -52.30623 -1.00948  -16.82203 1.000 42.62773 ? 225 LEU B N     1 
ATOM   802  C CA    . LEU A 1 107 ? -53.74822 -1.11578  -16.65021 1.000 41.87483 ? 225 LEU B CA    1 
ATOM   803  C C     . LEU A 1 107 ? -54.52367 -0.05853  -17.43506 1.000 42.67187 ? 225 LEU B C     1 
ATOM   804  O O     . LEU A 1 107 ? -55.73826 -0.20364  -17.59104 1.000 44.14580 ? 225 LEU B O     1 
ATOM   805  C CB    . LEU A 1 107 ? -54.09147 -1.01497  -15.15817 1.000 42.76413 ? 225 LEU B CB    1 
ATOM   806  C CG    . LEU A 1 107 ? -53.58715 -2.14789  -14.25870 1.000 47.57175 ? 225 LEU B CG    1 
ATOM   807  C CD1   . LEU A 1 107 ? -54.21686 -2.07362  -12.86819 1.000 45.53481 ? 225 LEU B CD1   1 
ATOM   808  C CD2   . LEU A 1 107 ? -53.82528 -3.51199  -14.88466 1.000 52.76350 ? 225 LEU B CD2   1 
ATOM   809  N N     . SER A 1 108 ? -53.84524 0.98122   -17.93177 1.000 42.13523 ? 226 SER B N     1 
ATOM   810  C CA    . SER A 1 108 ? -54.40243 2.14885   -18.62192 1.000 42.69964 ? 226 SER B CA    1 
ATOM   811  C C     . SER A 1 108 ? -55.06416 3.11562   -17.64552 1.000 41.47048 ? 226 SER B C     1 
ATOM   812  O O     . SER A 1 108 ? -54.80459 4.32355   -17.70952 1.000 36.86802 ? 226 SER B O     1 
ATOM   813  C CB    . SER A 1 108 ? -55.39938 1.75736   -19.72065 1.000 49.48729 ? 226 SER B CB    1 
ATOM   814  O OG    . SER A 1 108 ? -54.74414 1.01114   -20.73166 1.000 50.71318 ? 226 SER B OG    1 
ATOM   815  N N     . LYS A 1 109 ? -55.90706 2.60166   -16.75444 1.000 40.46560 ? 227 LYS B N     1 
ATOM   816  C CA    . LYS A 1 109 ? -56.51389 3.41633   -15.70347 1.000 41.38422 ? 227 LYS B CA    1 
ATOM   817  C C     . LYS A 1 109 ? -56.95522 2.50532   -14.56997 1.000 45.66713 ? 227 LYS B C     1 
ATOM   818  O O     . LYS A 1 109 ? -57.07106 1.28519   -14.73314 1.000 45.51654 ? 227 LYS B O     1 
ATOM   819  C CB    . LYS A 1 109 ? -57.67950 4.26068   -16.23723 1.000 44.11077 ? 227 LYS B CB    1 
ATOM   820  C CG    . LYS A 1 109 ? -58.79558 3.51098   -16.90538 1.000 43.92242 ? 227 LYS B CG    1 
ATOM   821  C CD    . LYS A 1 109 ? -59.60606 4.45821   -17.76269 1.000 44.98551 ? 227 LYS B CD    1 
ATOM   822  C CE    . LYS A 1 109 ? -60.77024 3.72292   -18.39783 1.000 51.04478 ? 227 LYS B CE    1 
ATOM   823  N NZ    . LYS A 1 109 ? -61.86025 3.51395   -17.40142 1.000 56.58366 ? 227 LYS B NZ    1 
ATOM   824  N N     . PHE A 1 110 ? -57.16793 3.10661   -13.40617 1.000 38.51222 ? 228 PHE B N     1 
ATOM   825  C CA    . PHE A 1 110 ? -57.50597 2.36767   -12.20210 1.000 38.72334 ? 228 PHE B CA    1 
ATOM   826  C C     . PHE A 1 110 ? -59.00099 2.47085   -11.91224 1.000 40.92906 ? 228 PHE B C     1 
ATOM   827  O O     . PHE A 1 110 ? -59.63513 3.50074   -12.16062 1.000 40.95261 ? 228 PHE B O     1 
ATOM   828  C CB    . PHE A 1 110 ? -56.73002 2.90458   -10.99296 1.000 38.51697 ? 228 PHE B CB    1 
ATOM   829  C CG    . PHE A 1 110 ? -55.22800 2.75101   -11.09260 1.000 37.58906 ? 228 PHE B CG    1 
ATOM   830  C CD1   . PHE A 1 110 ? -54.64735 1.79583   -11.93475 1.000 41.02653 ? 228 PHE B CD1   1 
ATOM   831  C CD2   . PHE A 1 110 ? -54.39616 3.55159   -10.31781 1.000 37.82976 ? 228 PHE B CD2   1 
ATOM   832  C CE1   . PHE A 1 110 ? -53.25976 1.64707   -11.98831 1.000 42.63538 ? 228 PHE B CE1   1 
ATOM   833  C CE2   . PHE A 1 110 ? -53.01810 3.41754   -10.37818 1.000 38.43017 ? 228 PHE B CE2   1 
ATOM   834  C CZ    . PHE A 1 110 ? -52.44704 2.46452   -11.21378 1.000 38.54169 ? 228 PHE B CZ    1 
ATOM   835  N N     . ASP A 1 111 ? -59.55326 1.41359   -11.32974 1.000 41.17471 ? 229 ASP B N     1 
ATOM   836  C CA    . ASP A 1 111 ? -60.94482 1.48440   -10.91049 1.000 44.58173 ? 229 ASP B CA    1 
ATOM   837  C C     . ASP A 1 111 ? -61.05498 2.31481   -9.63034  1.000 42.93677 ? 229 ASP B C     1 
ATOM   838  O O     . ASP A 1 111 ? -60.05333 2.75381   -9.05552  1.000 40.00741 ? 229 ASP B O     1 
ATOM   839  C CB    . ASP A 1 111 ? -61.53585 0.07694   -10.77716 1.000 40.78923 ? 229 ASP B CB    1 
ATOM   840  C CG    . ASP A 1 111 ? -60.85858 -0.77451  -9.70811  1.000 47.99035 ? 229 ASP B CG    1 
ATOM   841  O OD1   . ASP A 1 111 ? -60.46208 -0.27733  -8.64337  1.000 44.96245 ? 229 ASP B OD1   1 
ATOM   842  O OD2   . ASP A 1 111 ? -60.74801 -1.99632  -9.92316  1.000 54.56247 ? 229 ASP B OD2   1 
ATOM   843  N N     . GLU A 1 112 ? -62.29418 2.55450   -9.18064  1.000 43.67104 ? 230 GLU B N     1 
ATOM   844  C CA    . GLU A 1 112 ? -62.50651 3.46441   -8.05757  1.000 42.21459 ? 230 GLU B CA    1 
ATOM   845  C C     . GLU A 1 112 ? -62.00305 2.88657   -6.74595  1.000 45.09462 ? 230 GLU B C     1 
ATOM   846  O O     . GLU A 1 112 ? -61.51751 3.63575   -5.88951  1.000 43.69733 ? 230 GLU B O     1 
ATOM   847  C CB    . GLU A 1 112 ? -63.99014 3.83425   -7.93955  1.000 40.31274 ? 230 GLU B CB    1 
ATOM   848  C CG    . GLU A 1 112 ? -64.53219 4.53601   -9.15834  1.000 42.82861 ? 230 GLU B CG    1 
ATOM   849  C CD    . GLU A 1 112 ? -65.84932 5.23138   -8.87548  1.000 45.48068 ? 230 GLU B CD    1 
ATOM   850  O OE1   . GLU A 1 112 ? -66.84136 4.53007   -8.61457  1.000 46.50751 ? 230 GLU B OE1   1 
ATOM   851  O OE2   . GLU A 1 112 ? -65.89960 6.47650   -8.93022  1.000 48.47611 ? 230 GLU B OE2   1 
ATOM   852  N N     . GLN A 1 113 ? -62.11619 1.56717   -6.56333  1.000 41.73313 ? 231 GLN B N     1 
ATOM   853  C CA    . GLN A 1 113 ? -61.61552 0.93727   -5.34919  1.000 44.70532 ? 231 GLN B CA    1 
ATOM   854  C C     . GLN A 1 113 ? -60.09908 1.06248   -5.24335  1.000 43.74578 ? 231 GLN B C     1 
ATOM   855  O O     . GLN A 1 113 ? -59.57219 1.43382   -4.18597  1.000 43.92743 ? 231 GLN B O     1 
ATOM   856  C CB    . GLN A 1 113 ? -62.05965 -0.53490  -5.29275  1.000 46.07709 ? 231 GLN B CB    1 
ATOM   857  C CG    . GLN A 1 113 ? -63.58914 -0.73743  -5.21423  1.000 50.76096 ? 231 GLN B CG    1 
ATOM   858  C CD    . GLN A 1 113 ? -64.40673 -0.23930  -6.41680  1.000 52.68323 ? 231 GLN B CD    1 
ATOM   859  O OE1   . GLN A 1 113 ? -63.99987 -0.36973  -7.58824  1.000 51.93266 ? 231 GLN B OE1   1 
ATOM   860  N NE2   . GLN A 1 113 ? -65.55908 0.36935   -6.12070  1.000 49.21092 ? 231 GLN B NE2   1 
ATOM   861  N N     . ARG A 1 114 ? -59.37627 0.76717   -6.32580  1.000 42.01134 ? 232 ARG B N     1 
ATOM   862  C CA    . ARG A 1 114 ? -57.92118 0.89892   -6.27521  1.000 40.46936 ? 232 ARG B CA    1 
ATOM   863  C C     . ARG A 1 114 ? -57.52562 2.34891   -6.02645  1.000 39.33561 ? 232 ARG B C     1 
ATOM   864  O O     . ARG A 1 114 ? -56.70939 2.64040   -5.14851  1.000 38.60179 ? 232 ARG B O     1 
ATOM   865  C CB    . ARG A 1 114 ? -57.27974 0.40510   -7.56957  1.000 42.95485 ? 232 ARG B CB    1 
ATOM   866  C CG    . ARG A 1 114 ? -55.75263 0.33442   -7.45820  1.000 41.37016 ? 232 ARG B CG    1 
ATOM   867  C CD    . ARG A 1 114 ? -55.07608 0.01477   -8.77684  1.000 43.70661 ? 232 ARG B CD    1 
ATOM   868  N NE    . ARG A 1 114 ? -55.36774 -1.34583  -9.20572  1.000 49.50019 ? 232 ARG B NE    1 
ATOM   869  C CZ    . ARG A 1 114 ? -54.71652 -2.42268  -8.79093  1.000 52.88647 ? 232 ARG B CZ    1 
ATOM   870  N NH1   . ARG A 1 114 ? -53.75155 -2.34182  -7.89092  1.000 52.99096 ? 232 ARG B NH1   1 
ATOM   871  N NH2   . ARG A 1 114 ? -55.04412 -3.61207  -9.29234  1.000 56.81108 ? 232 ARG B NH2   1 
ATOM   872  N N     . THR A 1 115 ? -58.11601 3.26648   -6.79037  1.000 41.78258 ? 233 THR B N     1 
ATOM   873  C CA    . THR A 1 115 ? -57.82385 4.69146   -6.63812  1.000 38.01768 ? 233 THR B CA    1 
ATOM   874  C C     . THR A 1 115 ? -58.08147 5.15938   -5.20921  1.000 39.68227 ? 233 THR B C     1 
ATOM   875  O O     . THR A 1 115 ? -57.20442 5.76043   -4.57858  1.000 37.68788 ? 233 THR B O     1 
ATOM   876  C CB    . THR A 1 115 ? -58.65685 5.48979   -7.63607  1.000 38.24954 ? 233 THR B CB    1 
ATOM   877  O OG1   . THR A 1 115 ? -58.31367 5.09777   -8.97823  1.000 37.77841 ? 233 THR B OG1   1 
ATOM   878  C CG2   . THR A 1 115 ? -58.40690 7.00826   -7.47153  1.000 37.04343 ? 233 THR B CG2   1 
ATOM   879  N N     . ALA A 1 116 ? -59.28118 4.88989   -4.67362  1.000 39.12144 ? 234 ALA B N     1 
ATOM   880  C CA    . ALA A 1 116 ? -59.60705 5.36360   -3.32450  1.000 38.03609 ? 234 ALA B CA    1 
ATOM   881  C C     . ALA A 1 116 ? -58.67803 4.76353   -2.27755  1.000 39.24404 ? 234 ALA B C     1 
ATOM   882  O O     . ALA A 1 116 ? -58.32220 5.42559   -1.29318  1.000 37.71741 ? 234 ALA B O     1 
ATOM   883  C CB    . ALA A 1 116 ? -61.06782 5.04740   -2.98692  1.000 41.79651 ? 234 ALA B CB    1 
ATOM   884  N N     . THR A 1 117 ? -58.29499 3.49895   -2.44778  1.000 39.42272 ? 235 THR B N     1 
ATOM   885  C CA    . THR A 1 117 ? -57.36762 2.89719   -1.49458  1.000 39.62246 ? 235 THR B CA    1 
ATOM   886  C C     . THR A 1 117 ? -56.01383 3.59200   -1.53791  1.000 40.00126 ? 235 THR B C     1 
ATOM   887  O O     . THR A 1 117 ? -55.43980 3.89617   -0.49103  1.000 40.50743 ? 235 THR B O     1 
ATOM   888  C CB    . THR A 1 117 ? -57.22276 1.40692   -1.78286  1.000 44.78977 ? 235 THR B CB    1 
ATOM   889  O OG1   . THR A 1 117 ? -58.52806 0.81704   -1.75396  1.000 47.10303 ? 235 THR B OG1   1 
ATOM   890  C CG2   . THR A 1 117 ? -56.33095 0.73896   -0.73917  1.000 45.48456 ? 235 THR B CG2   1 
ATOM   891  N N     . TYR A 1 118 ? -55.50528 3.87580   -2.74179  1.000 36.44664 ? 236 TYR B N     1 
ATOM   892  C CA    . TYR A 1 118 ? -54.21133 4.55137   -2.86520  1.000 37.28147 ? 236 TYR B CA    1 
ATOM   893  C C     . TYR A 1 118 ? -54.26982 5.95878   -2.29222  1.000 36.51502 ? 236 TYR B C     1 
ATOM   894  O O     . TYR A 1 118 ? -53.35527 6.38567   -1.57162  1.000 38.70912 ? 236 TYR B O     1 
ATOM   895  C CB    . TYR A 1 118 ? -53.76909 4.62269   -4.32826  1.000 35.37052 ? 236 TYR B CB    1 
ATOM   896  C CG    . TYR A 1 118 ? -53.28142 3.32591   -4.95580  1.000 39.89578 ? 236 TYR B CG    1 
ATOM   897  C CD1   . TYR A 1 118 ? -53.13737 2.16042   -4.21089  1.000 46.02471 ? 236 TYR B CD1   1 
ATOM   898  C CD2   . TYR A 1 118 ? -52.93758 3.28929   -6.30493  1.000 39.55964 ? 236 TYR B CD2   1 
ATOM   899  C CE1   . TYR A 1 118 ? -52.66329 0.96692   -4.81456  1.000 45.25689 ? 236 TYR B CE1   1 
ATOM   900  C CE2   . TYR A 1 118 ? -52.47623 2.12386   -6.90454  1.000 43.28854 ? 236 TYR B CE2   1 
ATOM   901  C CZ    . TYR A 1 118 ? -52.34308 0.97204   -6.15792  1.000 46.82183 ? 236 TYR B CZ    1 
ATOM   902  O OH    . TYR A 1 118 ? -51.88713 -0.16641  -6.78349  1.000 47.66596 ? 236 TYR B OH    1 
ATOM   903  N N     . ILE A 1 119 ? -55.34406 6.69038   -2.59016  1.000 36.85474 ? 237 ILE B N     1 
ATOM   904  C CA    . ILE A 1 119 ? -55.45293 8.05243   -2.07672  1.000 38.15944 ? 237 ILE B CA    1 
ATOM   905  C C     . ILE A 1 119 ? -55.49297 8.03011   -0.55003  1.000 40.73248 ? 237 ILE B C     1 
ATOM   906  O O     . ILE A 1 119 ? -54.87448 8.87356   0.11442   1.000 39.11351 ? 237 ILE B O     1 
ATOM   907  C CB    . ILE A 1 119 ? -56.68143 8.75226   -2.69486  1.000 34.01764 ? 237 ILE B CB    1 
ATOM   908  C CG1   . ILE A 1 119 ? -56.50534 8.95343   -4.21145  1.000 34.30651 ? 237 ILE B CG1   1 
ATOM   909  C CG2   . ILE A 1 119 ? -56.97530 10.07875  -1.96169  1.000 33.51357 ? 237 ILE B CG2   1 
ATOM   910  C CD1   . ILE A 1 119 ? -55.27036 9.87769   -4.61295  1.000 36.23751 ? 237 ILE B CD1   1 
ATOM   911  N N     . THR A 1 120 ? -56.18517 7.03558   0.03200   1.000 39.53889 ? 238 THR B N     1 
ATOM   912  C CA    . THR A 1 120 ? -56.16992 6.85906   1.48716   1.000 39.49965 ? 238 THR B CA    1 
ATOM   913  C C     . THR A 1 120 ? -54.75161 6.69688   2.02622   1.000 41.71478 ? 238 THR B C     1 
ATOM   914  O O     . THR A 1 120 ? -54.35705 7.41273   2.94989   1.000 42.19946 ? 238 THR B O     1 
ATOM   915  C CB    . THR A 1 120 ? -57.04210 5.66247   1.89806   1.000 44.87966 ? 238 THR B CB    1 
ATOM   916  O OG1   . THR A 1 120 ? -58.41175 5.96861   1.60912   1.000 42.16303 ? 238 THR B OG1   1 
ATOM   917  C CG2   . THR A 1 120 ? -56.89722 5.36769   3.40459   1.000 43.49918 ? 238 THR B CG2   1 
ATOM   918  N N     . GLU A 1 121 ? -53.96076 5.77208   1.45306   1.000 41.32887 ? 239 GLU B N     1 
ATOM   919  C CA    . GLU A 1 121 ? -52.59498 5.56953   1.94084   1.000 40.15647 ? 239 GLU B CA    1 
ATOM   920  C C     . GLU A 1 121 ? -51.75653 6.83157   1.81198   1.000 39.54127 ? 239 GLU B C     1 
ATOM   921  O O     . GLU A 1 121 ? -50.97946 7.15964   2.71387   1.000 41.12725 ? 239 GLU B O     1 
ATOM   922  C CB    . GLU A 1 121 ? -51.92005 4.41308   1.20061   1.000 40.06337 ? 239 GLU B CB    1 
ATOM   923  C CG    . GLU A 1 121 ? -52.63625 3.07669   1.36267   1.000 41.20293 ? 239 GLU B CG    1 
ATOM   924  C CD    . GLU A 1 121 ? -52.05511 1.97734   0.50029   1.000 49.64756 ? 239 GLU B CD    1 
ATOM   925  O OE1   . GLU A 1 121 ? -50.83349 1.97088   0.29210   1.000 49.37164 ? 239 GLU B OE1   1 
ATOM   926  O OE2   . GLU A 1 121 ? -52.81964 1.09350   0.05856   1.000 57.04021 ? 239 GLU B OE2   1 
ATOM   927  N N     . LEU A 1 122 ? -51.88796 7.55198   0.69973   1.000 36.40571 ? 240 LEU B N     1 
ATOM   928  C CA    . LEU A 1 122 ? -51.08552 8.75991   0.52632   1.000 37.87165 ? 240 LEU B CA    1 
ATOM   929  C C     . LEU A 1 122 ? -51.50993 9.85486   1.49661   1.000 39.46108 ? 240 LEU B C     1 
ATOM   930  O O     . LEU A 1 122 ? -50.66165 10.56855  2.04580   1.000 38.47217 ? 240 LEU B O     1 
ATOM   931  C CB    . LEU A 1 122 ? -51.19229 9.24852   -0.91330  1.000 38.10843 ? 240 LEU B CB    1 
ATOM   932  C CG    . LEU A 1 122 ? -50.51125 8.26617   -1.86827  1.000 40.57847 ? 240 LEU B CG    1 
ATOM   933  C CD1   . LEU A 1 122 ? -51.01477 8.49182   -3.25056  1.000 43.86486 ? 240 LEU B CD1   1 
ATOM   934  C CD2   . LEU A 1 122 ? -48.99362 8.36167   -1.83552  1.000 44.04201 ? 240 LEU B CD2   1 
ATOM   935  N N     . ALA A 1 123 ? -52.81888 10.03383  1.68792   1.000 41.00033 ? 241 ALA B N     1 
ATOM   936  C CA    . ALA A 1 123 ? -53.28999 11.05579  2.61625   1.000 38.72084 ? 241 ALA B CA    1 
ATOM   937  C C     . ALA A 1 123 ? -52.78451 10.78246  4.03164   1.000 41.84778 ? 241 ALA B C     1 
ATOM   938  O O     . ALA A 1 123 ? -52.36956 11.70777  4.74413   1.000 37.86809 ? 241 ALA B O     1 
ATOM   939  C CB    . ALA A 1 123 ? -54.82562 11.12723  2.57710   1.000 36.62203 ? 241 ALA B CB    1 
ATOM   940  N N     . ASN A 1 124 ? -52.78168 9.51187   4.44660   1.000 39.21720 ? 242 ASN B N     1 
ATOM   941  C CA    . ASN A 1 124 ? -52.19188 9.15953   5.73362   1.000 41.67871 ? 242 ASN B CA    1 
ATOM   942  C C     . ASN A 1 124 ? -50.70955 9.50253   5.76403   1.000 41.51302 ? 242 ASN B C     1 
ATOM   943  O O     . ASN A 1 124 ? -50.21618 10.09220  6.73234   1.000 39.53747 ? 242 ASN B O     1 
ATOM   944  C CB    . ASN A 1 124 ? -52.38356 7.67111   6.02154   1.000 41.53188 ? 242 ASN B CB    1 
ATOM   945  C CG    . ASN A 1 124 ? -53.77673 7.36045   6.48246   1.000 48.85113 ? 242 ASN B CG    1 
ATOM   946  O OD1   . ASN A 1 124 ? -54.37256 8.12241   7.24251   1.000 49.87749 ? 242 ASN B OD1   1 
ATOM   947  N ND2   . ASN A 1 124 ? -54.31296 6.24844   6.01839   1.000 46.21024 ? 242 ASN B ND2   1 
ATOM   948  N N     . ALA A 1 125 ? -49.97846 9.13286   4.70972   1.000 40.36330 ? 243 ALA B N     1 
ATOM   949  C CA    . ALA A 1 125 ? -48.54738 9.43082   4.66401   1.000 39.63283 ? 243 ALA B CA    1 
ATOM   950  C C     . ALA A 1 125 ? -48.28849 10.93414  4.72767   1.000 39.68885 ? 243 ALA B C     1 
ATOM   951  O O     . ALA A 1 125 ? -47.36452 11.38857  5.41729   1.000 39.30352 ? 243 ALA B O     1 
ATOM   952  C CB    . ALA A 1 125 ? -47.93252 8.83604   3.39393   1.000 41.13735 ? 243 ALA B CB    1 
ATOM   953  N N     . LEU A 1 126 ? -49.08288 11.71947  3.99776   1.000 35.78953 ? 244 LEU B N     1 
ATOM   954  C CA    . LEU A 1 126 ? -48.88227 13.16177  3.97575   1.000 38.53415 ? 244 LEU B CA    1 
ATOM   955  C C     . LEU A 1 126 ? -49.27577 13.79235  5.30436   1.000 38.82674 ? 244 LEU B C     1 
ATOM   956  O O     . LEU A 1 126 ? -48.69981 14.80894  5.70068   1.000 40.92588 ? 244 LEU B O     1 
ATOM   957  C CB    . LEU A 1 126 ? -49.68479 13.76988  2.82519   1.000 38.80993 ? 244 LEU B CB    1 
ATOM   958  C CG    . LEU A 1 126 ? -49.16522 13.40800  1.41524   1.000 38.96653 ? 244 LEU B CG    1 
ATOM   959  C CD1   . LEU A 1 126 ? -50.21124 13.75849  0.38414   1.000 37.54067 ? 244 LEU B CD1   1 
ATOM   960  C CD2   . LEU A 1 126 ? -47.82191 14.07620  1.06718   1.000 37.13440 ? 244 LEU B CD2   1 
ATOM   961  N N     . SER A 1 127 ? -50.26733 13.22824  5.98930   1.000 40.71728 ? 245 SER B N     1 
ATOM   962  C CA    . SER A 1 127 ? -50.62422 13.76333  7.29803   1.000 40.39480 ? 245 SER B CA    1 
ATOM   963  C C     . SER A 1 127 ? -49.48146 13.56308  8.28415   1.000 44.99070 ? 245 SER B C     1 
ATOM   964  O O     . SER A 1 127 ? -49.18668 14.45178  9.09532   1.000 46.98623 ? 245 SER B O     1 
ATOM   965  C CB    . SER A 1 127 ? -51.90841 13.11121  7.80144   1.000 46.09173 ? 245 SER B CB    1 
ATOM   966  O OG    . SER A 1 127 ? -52.21734 13.57991  9.10730   1.000 53.74655 ? 245 SER B OG    1 
ATOM   967  N N     . TYR A 1 128 ? -48.82162 12.40539  8.21356   1.000 42.70486 ? 246 TYR B N     1 
ATOM   968  C CA    . TYR A 1 128 ? -47.62000 12.16523  9.00333   1.000 45.16351 ? 246 TYR B CA    1 
ATOM   969  C C     . TYR A 1 128 ? -46.52217 13.16292  8.65757   1.000 43.61919 ? 246 TYR B C     1 
ATOM   970  O O     . TYR A 1 128 ? -45.90549 13.75548  9.55627   1.000 42.66827 ? 246 TYR B O     1 
ATOM   971  C CB    . TYR A 1 128 ? -47.13820 10.72697  8.79365   1.000 44.75019 ? 246 TYR B CB    1 
ATOM   972  C CG    . TYR A 1 128 ? -45.78834 10.45515  9.42842   1.000 44.07978 ? 246 TYR B CG    1 
ATOM   973  C CD1   . TYR A 1 128 ? -45.67111 10.23502  10.79725  1.000 47.56559 ? 246 TYR B CD1   1 
ATOM   974  C CD2   . TYR A 1 128 ? -44.63149 10.44031  8.66864   1.000 44.56757 ? 246 TYR B CD2   1 
ATOM   975  C CE1   . TYR A 1 128 ? -44.43814 9.99794   11.37965  1.000 49.65914 ? 246 TYR B CE1   1 
ATOM   976  C CE2   . TYR A 1 128 ? -43.39687 10.21019  9.24580   1.000 45.25468 ? 246 TYR B CE2   1 
ATOM   977  C CZ    . TYR A 1 128 ? -43.30272 9.98594   10.59754  1.000 48.55522 ? 246 TYR B CZ    1 
ATOM   978  O OH    . TYR A 1 128 ? -42.06501 9.75610   11.16445  1.000 47.04998 ? 246 TYR B OH    1 
ATOM   979  N N     . CYS A 1 129 ? -46.26488 13.36646  7.35323   1.000 41.84625 ? 247 CYS B N     1 
ATOM   980  C CA    . CYS A 1 129 ? -45.25479 14.33599  6.92879   1.000 38.38405 ? 247 CYS B CA    1 
ATOM   981  C C     . CYS A 1 129 ? -45.54632 15.72048  7.49970   1.000 42.26797 ? 247 CYS B C     1 
ATOM   982  O O     . CYS A 1 129 ? -44.65586 16.38101  8.04992   1.000 41.61148 ? 247 CYS B O     1 
ATOM   983  C CB    . CYS A 1 129 ? -45.19315 14.41838  5.39810   1.000 40.40900 ? 247 CYS B CB    1 
ATOM   984  S SG    . CYS A 1 129 ? -44.39437 12.99897  4.57877   1.000 39.75599 ? 247 CYS B SG    1 
ATOM   985  N N     . HIS A 1 130 ? -46.78841 16.18952  7.35192   1.000 40.09258 ? 248 HIS B N     1 
ATOM   986  C CA    . HIS A 1 130 ? -47.11866 17.53858  7.80774   1.000 40.14186 ? 248 HIS B CA    1 
ATOM   987  C C     . HIS A 1 130 ? -46.93658 17.67064  9.31768   1.000 40.47252 ? 248 HIS B C     1 
ATOM   988  O O     . HIS A 1 130 ? -46.53626 18.73609  9.80345   1.000 44.78259 ? 248 HIS B O     1 
ATOM   989  C CB    . HIS A 1 130 ? -48.55198 17.90356  7.38604   1.000 41.39343 ? 248 HIS B CB    1 
ATOM   990  C CG    . HIS A 1 130 ? -48.71968 18.07342  5.90341   1.000 38.40410 ? 248 HIS B CG    1 
ATOM   991  N ND1   . HIS A 1 130 ? -49.91089 18.44571  5.31725   1.000 40.50277 ? 248 HIS B ND1   1 
ATOM   992  C CD2   . HIS A 1 130 ? -47.83374 17.92029  4.88830   1.000 39.17286 ? 248 HIS B CD2   1 
ATOM   993  C CE1   . HIS A 1 130 ? -49.75119 18.51840  4.00618   1.000 40.49554 ? 248 HIS B CE1   1 
ATOM   994  N NE2   . HIS A 1 130 ? -48.49783 18.20143  3.72060   1.000 35.40118 ? 248 HIS B NE2   1 
ATOM   995  N N     . SER A 1 131 ? -47.20485 16.59767  10.06325  1.000 40.81276 ? 249 SER B N     1 
ATOM   996  C CA    . SER A 1 131 ? -46.98627 16.60641  11.50547  1.000 45.28449 ? 249 SER B CA    1 
ATOM   997  C C     . SER A 1 131 ? -45.52130 16.83513  11.84160  1.000 48.29917 ? 249 SER B C     1 
ATOM   998  O O     . SER A 1 131 ? -45.20132 17.30434  12.93919  1.000 49.39535 ? 249 SER B O     1 
ATOM   999  C CB    . SER A 1 131 ? -47.45833 15.28276  12.10925  1.000 48.30290 ? 249 SER B CB    1 
ATOM   1000 O OG    . SER A 1 131 ? -46.46775 14.27958  11.92282  1.000 47.72516 ? 249 SER B OG    1 
ATOM   1001 N N     . LYS A 1 132 ? -44.62452 16.50216  10.91481  1.000 44.29970 ? 250 LYS B N     1 
ATOM   1002 C CA    . LYS A 1 132 ? -43.18971 16.70338  11.06127  1.000 46.65210 ? 250 LYS B CA    1 
ATOM   1003 C C     . LYS A 1 132 ? -42.73320 18.00238  10.41892  1.000 46.20654 ? 250 LYS B C     1 
ATOM   1004 O O     . LYS A 1 132 ? -41.52718 18.24167  10.30030  1.000 48.70480 ? 250 LYS B O     1 
ATOM   1005 C CB    . LYS A 1 132 ? -42.43712 15.54303  10.41979  1.000 46.45627 ? 250 LYS B CB    1 
ATOM   1006 C CG    . LYS A 1 132 ? -42.71455 14.18083  11.01199  1.000 47.28785 ? 250 LYS B CG    1 
ATOM   1007 C CD    . LYS A 1 132 ? -42.55284 14.16921  12.50760  1.000 55.04301 ? 250 LYS B CD    1 
ATOM   1008 C CE    . LYS A 1 132 ? -41.94926 12.85004  12.97829  1.000 56.04380 ? 250 LYS B CE    1 
ATOM   1009 N NZ    . LYS A 1 132 ? -42.06409 12.70804  14.47053  1.000 60.53075 ? 250 LYS B NZ    1 
ATOM   1010 N N     . ARG A 1 133 ? -43.66979 18.83509  9.97430   1.000 46.11050 ? 251 ARG B N     1 
ATOM   1011 C CA    . ARG A 1 133 ? -43.35988 20.04365  9.21231   1.000 46.59330 ? 251 ARG B CA    1 
ATOM   1012 C C     . ARG A 1 133 ? -42.63885 19.71421  7.89781   1.000 47.39832 ? 251 ARG B C     1 
ATOM   1013 O O     . ARG A 1 133 ? -41.84386 20.50407  7.39791   1.000 48.77754 ? 251 ARG B O     1 
ATOM   1014 C CB    . ARG A 1 133 ? -42.54181 21.04622  10.04173  1.000 53.87948 ? 251 ARG B CB    1 
ATOM   1015 C CG    . ARG A 1 133 ? -43.10840 21.34860  11.43722  1.000 59.05936 ? 251 ARG B CG    1 
ATOM   1016 C CD    . ARG A 1 133 ? -42.71929 22.76656  11.89895  1.000 62.05763 ? 251 ARG B CD    1 
ATOM   1017 N NE    . ARG A 1 133 ? -41.34030 22.87431  12.36751  1.000 63.69398 ? 251 ARG B NE    1 
ATOM   1018 C CZ    . ARG A 1 133 ? -40.96948 22.88022  13.64351  1.000 65.33297 ? 251 ARG B CZ    1 
ATOM   1019 N NH1   . ARG A 1 133 ? -41.85460 22.76798  14.62579  1.000 59.08859 ? 251 ARG B NH1   1 
ATOM   1020 N NH2   . ARG A 1 133 ? -39.67771 23.01668  13.94318  1.000 64.76571 ? 251 ARG B NH2   1 
ATOM   1021 N N     . VAL A 1 134 ? -42.91880 18.54859  7.32662   1.000 44.85737 ? 252 VAL B N     1 
ATOM   1022 C CA    . VAL A 1 134 ? -42.39655 18.14107  6.02145   1.000 43.97291 ? 252 VAL B CA    1 
ATOM   1023 C C     . VAL A 1 134 ? -43.51507 18.30063  5.00119   1.000 44.61147 ? 252 VAL B C     1 
ATOM   1024 O O     . VAL A 1 134 ? -44.56244 17.65184  5.11889   1.000 42.75932 ? 252 VAL B O     1 
ATOM   1025 C CB    . VAL A 1 134 ? -41.89122 16.69359  6.06453   1.000 43.82564 ? 252 VAL B CB    1 
ATOM   1026 C CG1   . VAL A 1 134 ? -41.47269 16.19723  4.67852   1.000 42.62245 ? 252 VAL B CG1   1 
ATOM   1027 C CG2   . VAL A 1 134 ? -40.74645 16.57070  7.08404   1.000 46.71848 ? 252 VAL B CG2   1 
ATOM   1028 N N     . ILE A 1 135 ? -43.30626 19.16783  4.00700   1.000 46.01473 ? 253 ILE B N     1 
ATOM   1029 C CA    . ILE A 1 135 ? -44.33489 19.47094  3.02081   1.000 43.55003 ? 253 ILE B CA    1 
ATOM   1030 C C     . ILE A 1 135 ? -43.76561 19.38802  1.60539   1.000 46.07831 ? 253 ILE B C     1 
ATOM   1031 O O     . ILE A 1 135 ? -42.55032 19.35185  1.38413   1.000 44.35746 ? 253 ILE B O     1 
ATOM   1032 C CB    . ILE A 1 135 ? -44.98204 20.85752  3.25736   1.000 44.70603 ? 253 ILE B CB    1 
ATOM   1033 C CG1   . ILE A 1 135 ? -44.02570 21.99545  2.85876   1.000 47.17788 ? 253 ILE B CG1   1 
ATOM   1034 C CG2   . ILE A 1 135 ? -45.42005 20.99869  4.70873   1.000 43.79828 ? 253 ILE B CG2   1 
ATOM   1035 C CD1   . ILE A 1 135 ? -44.73711 23.28556  2.43516   1.000 42.54577 ? 253 ILE B CD1   1 
ATOM   1036 N N     . HIS A 1 136 ? -44.68509 19.35152  0.64496   1.000 36.42316 ? 254 HIS B N     1 
ATOM   1037 C CA    . HIS A 1 136 ? -44.38799 19.30126  -0.78626  1.000 40.16742 ? 254 HIS B CA    1 
ATOM   1038 C C     . HIS A 1 136 ? -43.54852 18.06945  -1.15293  1.000 41.16584 ? 254 HIS B C     1 
ATOM   1039 O O     . HIS A 1 136 ? -42.42175 18.16485  -1.63174  1.000 41.78591 ? 254 HIS B O     1 
ATOM   1040 C CB    . HIS A 1 136 ? -43.71399 20.59014  -1.26454  1.000 42.61787 ? 254 HIS B CB    1 
ATOM   1041 C CG    . HIS A 1 136 ? -43.67017 20.71227  -2.75127  1.000 42.83439 ? 254 HIS B CG    1 
ATOM   1042 N ND1   . HIS A 1 136 ? -44.64104 20.16964  -3.56750  1.000 43.95470 ? 254 HIS B ND1   1 
ATOM   1043 C CD2   . HIS A 1 136 ? -42.74316 21.25534  -3.57405  1.000 42.10132 ? 254 HIS B CD2   1 
ATOM   1044 C CE1   . HIS A 1 136 ? -44.33060 20.40898  -4.83046  1.000 38.67513 ? 254 HIS B CE1   1 
ATOM   1045 N NE2   . HIS A 1 136 ? -43.18607 21.06955  -4.86135  1.000 45.40591 ? 254 HIS B NE2   1 
ATOM   1046 N N     . ARG A 1 137 ? -44.12472 16.89671  -0.94357  1.000 37.21917 ? 255 ARG B N     1 
ATOM   1047 C CA    . ARG A 1 137 ? -43.53030 15.71323  -1.54896  1.000 37.43711 ? 255 ARG B CA    1 
ATOM   1048 C C     . ARG A 1 137 ? -44.00405 15.67206  -2.99394  1.000 37.84353 ? 255 ARG B C     1 
ATOM   1049 O O     . ARG A 1 137 ? -45.17313 15.95747  -3.27340  1.000 38.56850 ? 255 ARG B O     1 
ATOM   1050 C CB    . ARG A 1 137 ? -43.93360 14.44100  -0.80280  1.000 39.40558 ? 255 ARG B CB    1 
ATOM   1051 C CG    . ARG A 1 137 ? -43.66130 14.50310  0.69937   1.000 41.89884 ? 255 ARG B CG    1 
ATOM   1052 C CD    . ARG A 1 137 ? -42.20531 14.82201  0.95978   1.000 41.87445 ? 255 ARG B CD    1 
ATOM   1053 N NE    . ARG A 1 137 ? -41.39517 13.62352  0.76453   1.000 44.65629 ? 255 ARG B NE    1 
ATOM   1054 C CZ    . ARG A 1 137 ? -40.22155 13.41428  1.34906   1.000 50.30038 ? 255 ARG B CZ    1 
ATOM   1055 N NH1   . ARG A 1 137 ? -39.72174 14.27652  2.22671   1.000 47.46112 ? 255 ARG B NH1   1 
ATOM   1056 N NH2   . ARG A 1 137 ? -39.52821 12.31828  1.04194   1.000 44.99254 ? 255 ARG B NH2   1 
ATOM   1057 N N     . ASP A 1 138 ? -43.08914 15.35757  -3.91667  1.000 37.98660 ? 256 ASP B N     1 
ATOM   1058 C CA    . ASP A 1 138 ? -43.42943 15.24681  -5.34376  1.000 37.41464 ? 256 ASP B CA    1 
ATOM   1059 C C     . ASP A 1 138 ? -44.03739 13.86608  -5.57043  1.000 36.07053 ? 256 ASP B C     1 
ATOM   1060 O O     . ASP A 1 138 ? -43.32798 12.87802  -5.79041  1.000 33.96155 ? 256 ASP B O     1 
ATOM   1061 C CB    . ASP A 1 138 ? -42.18990 15.47132  -6.20312  1.000 36.90449 ? 256 ASP B CB    1 
ATOM   1062 C CG    . ASP A 1 138 ? -42.50542 15.55400  -7.69296  1.000 42.32010 ? 256 ASP B CG    1 
ATOM   1063 O OD1   . ASP A 1 138 ? -43.70792 15.51742  -8.07004  1.000 37.28998 ? 256 ASP B OD1   1 
ATOM   1064 O OD2   . ASP A 1 138 ? -41.54660 15.69871  -8.48642  1.000 40.53393 ? 256 ASP B OD2   1 
ATOM   1065 N N     . ILE A 1 139 ? -45.36871 13.78158  -5.48526  1.000 33.15187 ? 257 ILE B N     1 
ATOM   1066 C CA    . ILE A 1 139 ? -46.03702 12.48788  -5.46978  1.000 33.62705 ? 257 ILE B CA    1 
ATOM   1067 C C     . ILE A 1 139 ? -46.58284 12.16012  -6.84404  1.000 34.97567 ? 257 ILE B C     1 
ATOM   1068 O O     . ILE A 1 139 ? -47.56413 11.41830  -6.95173  1.000 35.16907 ? 257 ILE B O     1 
ATOM   1069 C CB    . ILE A 1 139 ? -47.18674 12.42847  -4.43565  1.000 36.85642 ? 257 ILE B CB    1 
ATOM   1070 C CG1   . ILE A 1 139 ? -48.21734 13.51973  -4.71987  1.000 38.28403 ? 257 ILE B CG1   1 
ATOM   1071 C CG2   . ILE A 1 139 ? -46.63643 12.54326  -3.01931  1.000 36.72867 ? 257 ILE B CG2   1 
ATOM   1072 C CD1   . ILE A 1 139 ? -49.50253 13.38888  -3.87360  1.000 38.92580 ? 257 ILE B CD1   1 
ATOM   1073 N N     . LYS A 1 140 ? -45.95496 12.69713  -7.90828  1.000 31.77215 ? 258 LYS B N     1 
ATOM   1074 C CA    . LYS A 1 140 ? -46.26205 12.17648  -9.23555  1.000 32.98260 ? 258 LYS B CA    1 
ATOM   1075 C C     . LYS A 1 140 ? -46.07449 10.65457  -9.23652  1.000 33.24441 ? 258 LYS B C     1 
ATOM   1076 O O     . LYS A 1 140 ? -45.26231 10.13031  -8.45088  1.000 33.68963 ? 258 LYS B O     1 
ATOM   1077 C CB    . LYS A 1 140 ? -45.37593 12.85388  -10.28096 1.000 30.75009 ? 258 LYS B CB    1 
ATOM   1078 C CG    . LYS A 1 140 ? -43.91219 12.49756  -10.09252 1.000 34.49235 ? 258 LYS B CG    1 
ATOM   1079 C CD    . LYS A 1 140 ? -43.01886 13.19835  -11.12056 1.000 37.23819 ? 258 LYS B CD    1 
ATOM   1080 C CE    . LYS A 1 140 ? -41.55843 12.86696  -10.80496 1.000 41.02022 ? 258 LYS B CE    1 
ATOM   1081 N NZ    . LYS A 1 140 ? -40.62068 13.44946  -11.78430 1.000 39.97990 ? 258 LYS B NZ    1 
ATOM   1082 N N     . PRO A 1 141 ? -46.80543 9.91681   -10.08378 1.000 34.58547 ? 259 PRO B N     1 
ATOM   1083 C CA    . PRO A 1 141 ? -46.83829 8.44186   -9.95834  1.000 36.20533 ? 259 PRO B CA    1 
ATOM   1084 C C     . PRO A 1 141 ? -45.49097 7.77042   -10.17039 1.000 36.07287 ? 259 PRO B C     1 
ATOM   1085 O O     . PRO A 1 141 ? -45.30943 6.63248   -9.71082  1.000 36.13790 ? 259 PRO B O     1 
ATOM   1086 C CB    . PRO A 1 141 ? -47.82933 8.00185   -11.05157 1.000 36.11328 ? 259 PRO B CB    1 
ATOM   1087 C CG    . PRO A 1 141 ? -48.32224 9.20956   -11.70487 1.000 38.16771 ? 259 PRO B CG    1 
ATOM   1088 C CD    . PRO A 1 141 ? -47.68112 10.42410  -11.15532 1.000 38.30465 ? 259 PRO B CD    1 
ATOM   1089 N N     . GLU A 1 142 ? -44.56056 8.41577   -10.88157 1.000 37.07317 ? 260 GLU B N     1 
ATOM   1090 C CA    . GLU A 1 142 ? -43.21354 7.86900   -11.00327 1.000 37.54027 ? 260 GLU B CA    1 
ATOM   1091 C C     . GLU A 1 142 ? -42.43903 7.88877   -9.69157  1.000 40.58101 ? 260 GLU B C     1 
ATOM   1092 O O     . GLU A 1 142 ? -41.42954 7.17698   -9.57540  1.000 38.59005 ? 260 GLU B O     1 
ATOM   1093 C CB    . GLU A 1 142 ? -42.41278 8.61510   -12.07530 1.000 41.30201 ? 260 GLU B CB    1 
ATOM   1094 C CG    . GLU A 1 142 ? -43.07417 8.87259   -13.44278 1.000 46.45030 ? 260 GLU B CG    1 
ATOM   1095 C CD    . GLU A 1 142 ? -43.99859 10.09289  -13.54904 1.000 45.31614 ? 260 GLU B CD    1 
ATOM   1096 O OE1   . GLU A 1 142 ? -44.88880 10.29240  -12.69934 1.000 38.09099 ? 260 GLU B OE1   1 
ATOM   1097 O OE2   . GLU A 1 142 ? -43.81263 10.87251  -14.51500 1.000 48.68336 ? 260 GLU B OE2   1 
ATOM   1098 N N     . ASN A 1 143 ? -42.87657 8.67700   -8.70954  1.000 36.59790 ? 261 ASN B N     1 
ATOM   1099 C CA    . ASN A 1 143 ? -42.23431 8.73762   -7.39893  1.000 35.88044 ? 261 ASN B CA    1 
ATOM   1100 C C     . ASN A 1 143 ? -42.96151 7.91561   -6.35777  1.000 37.02400 ? 261 ASN B C     1 
ATOM   1101 O O     . ASN A 1 143 ? -42.59739 7.97020   -5.17749  1.000 38.18653 ? 261 ASN B O     1 
ATOM   1102 C CB    . ASN A 1 143 ? -42.12202 10.18595  -6.89587  1.000 33.67219 ? 261 ASN B CB    1 
ATOM   1103 C CG    . ASN A 1 143 ? -40.98930 10.93694  -7.53812  1.000 39.31782 ? 261 ASN B CG    1 
ATOM   1104 O OD1   . ASN A 1 143 ? -40.08282 10.33338  -8.10299  1.000 38.89861 ? 261 ASN B OD1   1 
ATOM   1105 N ND2   . ASN A 1 143 ? -41.01207 12.26452  -7.43158  1.000 38.17807 ? 261 ASN B ND2   1 
ATOM   1106 N N     . LEU A 1 144 ? -43.98758 7.17732   -6.76068  1.000 33.53283 ? 262 LEU B N     1 
ATOM   1107 C CA    . LEU A 1 144 ? -44.77793 6.34353   -5.86771  1.000 35.81593 ? 262 LEU B CA    1 
ATOM   1108 C C     . LEU A 1 144 ? -44.50771 4.88566   -6.21263  1.000 35.72286 ? 262 LEU B C     1 
ATOM   1109 O O     . LEU A 1 144 ? -44.68117 4.47494   -7.36993  1.000 36.20022 ? 262 LEU B O     1 
ATOM   1110 C CB    . LEU A 1 144 ? -46.26969 6.65042   -6.01917  1.000 34.81472 ? 262 LEU B CB    1 
ATOM   1111 C CG    . LEU A 1 144 ? -46.64230 8.11563   -5.79906  1.000 34.24531 ? 262 LEU B CG    1 
ATOM   1112 C CD1   . LEU A 1 144 ? -48.14531 8.25609   -5.99012  1.000 35.29946 ? 262 LEU B CD1   1 
ATOM   1113 C CD2   . LEU A 1 144 ? -46.25548 8.50627   -4.35485  1.000 37.55549 ? 262 LEU B CD2   1 
ATOM   1114 N N     . LEU A 1 145 ? -44.10394 4.10759   -5.21662  1.000 35.45579 ? 263 LEU B N     1 
ATOM   1115 C CA    . LEU A 1 145 ? -43.67321 2.73686   -5.44777  1.000 35.72645 ? 263 LEU B CA    1 
ATOM   1116 C C     . LEU A 1 145 ? -44.58965 1.75202   -4.73460  1.000 41.71318 ? 263 LEU B C     1 
ATOM   1117 O O     . LEU A 1 145 ? -45.32707 2.09614   -3.80836  1.000 41.08529 ? 263 LEU B O     1 
ATOM   1118 C CB    . LEU A 1 145 ? -42.23091 2.51932   -4.98238  1.000 35.68130 ? 263 LEU B CB    1 
ATOM   1119 C CG    . LEU A 1 145 ? -41.23257 3.58029   -5.41788  1.000 40.35262 ? 263 LEU B CG    1 
ATOM   1120 C CD1   . LEU A 1 145 ? -39.86200 3.21479   -4.89325  1.000 40.78813 ? 263 LEU B CD1   1 
ATOM   1121 C CD2   . LEU A 1 145 ? -41.19303 3.74490   -6.93898  1.000 38.48340 ? 263 LEU B CD2   1 
ATOM   1122 N N     . LEU A 1 146 ? -44.52664 0.50487   -5.17116  1.000 40.21916 ? 264 LEU B N     1 
ATOM   1123 C CA    . LEU A 1 146 ? -45.39072 -0.54345  -4.64725  1.000 40.78275 ? 264 LEU B CA    1 
ATOM   1124 C C     . LEU A 1 146 ? -44.54591 -1.54942  -3.87964  1.000 44.21728 ? 264 LEU B C     1 
ATOM   1125 O O     . LEU A 1 146 ? -43.65756 -2.18305  -4.46339  1.000 41.80048 ? 264 LEU B O     1 
ATOM   1126 C CB    . LEU A 1 146 ? -46.15328 -1.23577  -5.77829  1.000 41.72195 ? 264 LEU B CB    1 
ATOM   1127 C CG    . LEU A 1 146 ? -47.15606 -0.31319  -6.48829  1.000 43.88962 ? 264 LEU B CG    1 
ATOM   1128 C CD1   . LEU A 1 146 ? -47.64141 -0.90784  -7.80182  1.000 47.73416 ? 264 LEU B CD1   1 
ATOM   1129 C CD2   . LEU A 1 146 ? -48.30468 -0.07920  -5.55771  1.000 47.49196 ? 264 LEU B CD2   1 
ATOM   1130 N N     . GLY A 1 147 ? -44.80653 -1.66842  -2.57620  1.000 43.63499 ? 265 GLY B N     1 
ATOM   1131 C CA    . GLY A 1 147 ? -44.14490 -2.66685  -1.75698  1.000 49.74145 ? 265 GLY B CA    1 
ATOM   1132 C C     . GLY A 1 147 ? -44.66569 -4.06523  -2.04222  1.000 52.18012 ? 265 GLY B C     1 
ATOM   1133 O O     . GLY A 1 147 ? -45.62687 -4.26132  -2.78555  1.000 54.61001 ? 265 GLY B O     1 
ATOM   1134 N N     . SER A 1 148 ? -44.01611 -5.06587  -1.42753  1.000 54.72619 ? 266 SER B N     1 
ATOM   1135 C CA    . SER A 1 148 ? -44.31262 -6.45472  -1.78208  1.000 56.67947 ? 266 SER B CA    1 
ATOM   1136 C C     . SER A 1 148 ? -45.77489 -6.81906  -1.50687  1.000 59.07269 ? 266 SER B C     1 
ATOM   1137 O O     . SER A 1 148 ? -46.32996 -7.70023  -2.17662  1.000 59.97302 ? 266 SER B O     1 
ATOM   1138 C CB    . SER A 1 148 ? -43.36681 -7.40862  -1.03889  1.000 58.16732 ? 266 SER B CB    1 
ATOM   1139 O OG    . SER A 1 148 ? -43.68707 -7.48673  0.34445   1.000 61.96749 ? 266 SER B OG    1 
ATOM   1140 N N     . ALA A 1 149 ? -46.41942 -6.15631  -0.54017  1.000 57.60765 ? 267 ALA B N     1 
ATOM   1141 C CA    . ALA A 1 149 ? -47.84815 -6.33995  -0.29317  1.000 58.65922 ? 267 ALA B CA    1 
ATOM   1142 C C     . ALA A 1 149 ? -48.71831 -5.41621  -1.14054  1.000 55.81521 ? 267 ALA B C     1 
ATOM   1143 O O     . ALA A 1 149 ? -49.93728 -5.37200  -0.94081  1.000 54.89055 ? 267 ALA B O     1 
ATOM   1144 C CB    . ALA A 1 149 ? -48.16753 -6.12768  1.18997   1.000 56.31065 ? 267 ALA B CB    1 
ATOM   1145 N N     . GLY A 1 150 ? -48.12194 -4.67555  -2.07261  1.000 53.59174 ? 268 GLY B N     1 
ATOM   1146 C CA    . GLY A 1 150 ? -48.86386 -3.72731  -2.87421  1.000 51.42733 ? 268 GLY B CA    1 
ATOM   1147 C C     . GLY A 1 150 ? -49.16060 -2.40852  -2.19152  1.000 51.44014 ? 268 GLY B C     1 
ATOM   1148 O O     . GLY A 1 150 ? -49.99947 -1.64718  -2.69098  1.000 51.04987 ? 268 GLY B O     1 
ATOM   1149 N N     . GLU A 1 151 ? -48.51605 -2.11322  -1.06651  1.000 48.50390 ? 269 GLU B N     1 
ATOM   1150 C CA    . GLU A 1 151 ? -48.76186 -0.83895  -0.41503  1.000 51.70256 ? 269 GLU B CA    1 
ATOM   1151 C C     . GLU A 1 151 ? -47.99301 0.23653   -1.17074  1.000 45.45803 ? 269 GLU B C     1 
ATOM   1152 O O     . GLU A 1 151 ? -46.93562 -0.02721  -1.75244  1.000 45.29138 ? 269 GLU B O     1 
ATOM   1153 C CB    . GLU A 1 151 ? -48.27779 -0.85239  1.03228   1.000 47.49376 ? 269 GLU B CB    1 
ATOM   1154 C CG    . GLU A 1 151 ? -46.77565 -1.02788  1.14302   1.000 52.32452 ? 269 GLU B CG    1 
ATOM   1155 C CD    . GLU A 1 151 ? -46.31764 -2.45007  1.38969   1.000 57.85013 ? 269 GLU B CD    1 
ATOM   1156 O OE1   . GLU A 1 151 ? -46.80915 -3.36623  0.69463   1.000 56.54144 ? 269 GLU B OE1   1 
ATOM   1157 O OE2   . GLU A 1 151 ? -45.42511 -2.65367  2.25525   1.000 64.01142 ? 269 GLU B OE2   1 
ATOM   1158 N N     . LEU A 1 152 ? -48.52581 1.44737   -1.14993  1.000 44.92718 ? 270 LEU B N     1 
ATOM   1159 C CA    . LEU A 1 152 ? -47.86992 2.58135   -1.78358  1.000 43.75508 ? 270 LEU B CA    1 
ATOM   1160 C C     . LEU A 1 152 ? -46.77270 3.13721   -0.89410  1.000 41.58380 ? 270 LEU B C     1 
ATOM   1161 O O     . LEU A 1 152 ? -46.92781 3.21283   0.32643   1.000 43.18228 ? 270 LEU B O     1 
ATOM   1162 C CB    . LEU A 1 152 ? -48.89312 3.66955   -2.08612  1.000 45.69985 ? 270 LEU B CB    1 
ATOM   1163 C CG    . LEU A 1 152 ? -49.15333 3.84911   -3.57214  1.000 47.11447 ? 270 LEU B CG    1 
ATOM   1164 C CD1   . LEU A 1 152 ? -49.87535 2.64062   -4.03845  1.000 49.12887 ? 270 LEU B CD1   1 
ATOM   1165 C CD2   . LEU A 1 152 ? -50.03768 5.07501   -3.77686  1.000 42.37139 ? 270 LEU B CD2   1 
ATOM   1166 N N     . LYS A 1 153 ? -45.65971 3.54101   -1.51568  1.000 40.33990 ? 271 LYS B N     1 
ATOM   1167 C CA    . LYS A 1 153 ? -44.53682 4.14724   -0.80507  1.000 41.52750 ? 271 LYS B CA    1 
ATOM   1168 C C     . LYS A 1 153 ? -44.18158 5.45566   -1.48579  1.000 37.20542 ? 271 LYS B C     1 
ATOM   1169 O O     . LYS A 1 153 ? -43.82804 5.45754   -2.67139  1.000 36.63057 ? 271 LYS B O     1 
ATOM   1170 C CB    . LYS A 1 153 ? -43.29986 3.23477   -0.79877  1.000 44.96336 ? 271 LYS B CB    1 
ATOM   1171 C CG    . LYS A 1 153 ? -43.57648 1.80203   -0.39096  1.000 47.32189 ? 271 LYS B CG    1 
ATOM   1172 C CD    . LYS A 1 153 ? -43.27636 1.62975   1.07364   1.000 44.77813 ? 271 LYS B CD    1 
ATOM   1173 C CE    . LYS A 1 153 ? -43.50466 0.19205   1.52948   1.000 45.43457 ? 271 LYS B CE    1 
ATOM   1174 N NZ    . LYS A 1 153 ? -43.34260 0.16576   3.01893   1.000 44.46803 ? 271 LYS B NZ    1 
ATOM   1175 N N     . ILE A 1 154 ? -44.26759 6.56061   -0.74488  1.000 37.21587 ? 272 ILE B N     1 
ATOM   1176 C CA    . ILE A 1 154 ? -43.77216 7.83695   -1.24954  1.000 35.48096 ? 272 ILE B CA    1 
ATOM   1177 C C     . ILE A 1 154 ? -42.25030 7.77424   -1.32949  1.000 36.98461 ? 272 ILE B C     1 
ATOM   1178 O O     . ILE A 1 154 ? -41.58302 7.50630   -0.32637  1.000 37.06723 ? 272 ILE B O     1 
ATOM   1179 C CB    . ILE A 1 154 ? -44.22427 8.99320   -0.35117  1.000 38.68381 ? 272 ILE B CB    1 
ATOM   1180 C CG1   . ILE A 1 154 ? -45.75306 9.14782   -0.39711  1.000 37.42198 ? 272 ILE B CG1   1 
ATOM   1181 C CG2   . ILE A 1 154 ? -43.48062 10.25877  -0.75068  1.000 38.33841 ? 272 ILE B CG2   1 
ATOM   1182 C CD1   . ILE A 1 154 ? -46.27418 10.28204  0.45546   1.000 42.95489 ? 272 ILE B CD1   1 
ATOM   1183 N N     . ALA A 1 155 ? -41.68986 8.02266   -2.52135  1.000 35.05781 ? 273 ALA B N     1 
ATOM   1184 C CA    . ALA A 1 155 ? -40.26089 7.76947   -2.73897  1.000 35.84550 ? 273 ALA B CA    1 
ATOM   1185 C C     . ALA A 1 155 ? -39.59113 8.91136   -3.51253  1.000 39.64619 ? 273 ALA B C     1 
ATOM   1186 O O     . ALA A 1 155 ? -38.67417 8.69587   -4.31676  1.000 39.04893 ? 273 ALA B O     1 
ATOM   1187 C CB    . ALA A 1 155 ? -40.04862 6.44175   -3.47392  1.000 36.22293 ? 273 ALA B CB    1 
ATOM   1188 N N     . ASP A 1 156 ? -40.01303 10.14654  -3.28666  1.000 33.26383 ? 274 ASP B N     1 
ATOM   1189 C CA    . ASP A 1 156 ? -39.39985 11.22530  -4.06294  1.000 33.47173 ? 274 ASP B CA    1 
ATOM   1190 C C     . ASP A 1 156 ? -38.01463 11.63088  -3.55470  1.000 36.87737 ? 274 ASP B C     1 
ATOM   1191 O O     . ASP A 1 156 ? -37.34476 12.43201  -4.21354  1.000 39.74372 ? 274 ASP B O     1 
ATOM   1192 C CB    . ASP A 1 156 ? -40.34804 12.43788  -4.10417  1.000 36.64438 ? 274 ASP B CB    1 
ATOM   1193 C CG    . ASP A 1 156 ? -40.65161 12.98607  -2.73307  1.000 39.93446 ? 274 ASP B CG    1 
ATOM   1194 O OD1   . ASP A 1 156 ? -40.80270 12.17235  -1.79393  1.000 42.50244 ? 274 ASP B OD1   1 
ATOM   1195 O OD2   . ASP A 1 156 ? -40.75999 14.22861  -2.59542  1.000 41.55454 ? 274 ASP B OD2   1 
ATOM   1196 N N     . PHE A 1 157 ? -37.55681 11.06592  -2.44054  1.000 39.77072 ? 275 PHE B N     1 
ATOM   1197 C CA    . PHE A 1 157 ? -36.30225 11.48849  -1.82745  1.000 38.69680 ? 275 PHE B CA    1 
ATOM   1198 C C     . PHE A 1 157 ? -35.11181 11.19703  -2.73383  1.000 40.91160 ? 275 PHE B C     1 
ATOM   1199 O O     . PHE A 1 157 ? -34.99036 10.10845  -3.30894  1.000 39.12104 ? 275 PHE B O     1 
ATOM   1200 C CB    . PHE A 1 157 ? -36.13966 10.77899  -0.47858  1.000 40.98724 ? 275 PHE B CB    1 
ATOM   1201 C CG    . PHE A 1 157 ? -34.75725 10.85651  0.09078   1.000 43.22327 ? 275 PHE B CG    1 
ATOM   1202 C CD1   . PHE A 1 157 ? -34.24064 12.07222  0.53353   1.000 45.01626 ? 275 PHE B CD1   1 
ATOM   1203 C CD2   . PHE A 1 157 ? -33.97608 9.71211   0.20302   1.000 42.97617 ? 275 PHE B CD2   1 
ATOM   1204 C CE1   . PHE A 1 157 ? -32.95900 12.13069  1.06926   1.000 43.95302 ? 275 PHE B CE1   1 
ATOM   1205 C CE2   . PHE A 1 157 ? -32.70094 9.77310   0.72854   1.000 45.10551 ? 275 PHE B CE2   1 
ATOM   1206 C CZ    . PHE A 1 157 ? -32.19545 10.98252  1.16527   1.000 45.98504 ? 275 PHE B CZ    1 
ATOM   1207 N N     . GLY A 1 158 ? -34.20535 12.17246  -2.83093  1.000 39.64230 ? 276 GLY B N     1 
ATOM   1208 C CA    . GLY A 1 158 ? -33.04258 12.03301  -3.67650  1.000 38.06214 ? 276 GLY B CA    1 
ATOM   1209 C C     . GLY A 1 158 ? -33.27560 12.39891  -5.12455  1.000 40.13542 ? 276 GLY B C     1 
ATOM   1210 O O     . GLY A 1 158 ? -32.41345 12.10431  -5.96121  1.000 39.84314 ? 276 GLY B O     1 
ATOM   1211 N N     . TRP A 1 159 ? -34.42361 13.02061  -5.43872  1.000 39.71567 ? 277 TRP B N     1 
ATOM   1212 C CA    . TRP A 1 159 ? -34.82054 13.48544  -6.77153  1.000 37.96417 ? 277 TRP B CA    1 
ATOM   1213 C C     . TRP A 1 159 ? -35.27443 12.36214  -7.70480  1.000 41.14566 ? 277 TRP B C     1 
ATOM   1214 O O     . TRP A 1 159 ? -35.02378 11.17445  -7.46437  1.000 37.98237 ? 277 TRP B O     1 
ATOM   1215 C CB    . TRP A 1 159 ? -33.69408 14.27902  -7.44359  1.000 42.68074 ? 277 TRP B CB    1 
ATOM   1216 C CG    . TRP A 1 159 ? -33.43610 15.61312  -6.80872  1.000 45.75810 ? 277 TRP B CG    1 
ATOM   1217 C CD1   . TRP A 1 159 ? -34.16314 16.75417  -6.98152  1.000 46.56880 ? 277 TRP B CD1   1 
ATOM   1218 C CD2   . TRP A 1 159 ? -32.38662 15.94319  -5.87875  1.000 46.36160 ? 277 TRP B CD2   1 
ATOM   1219 N NE1   . TRP A 1 159 ? -33.62667 17.77764  -6.23069  1.000 51.10366 ? 277 TRP B NE1   1 
ATOM   1220 C CE2   . TRP A 1 159 ? -32.53782 17.30713  -5.54479  1.000 48.93122 ? 277 TRP B CE2   1 
ATOM   1221 C CE3   . TRP A 1 159 ? -31.33828 15.22026  -5.30276  1.000 44.05433 ? 277 TRP B CE3   1 
ATOM   1222 C CZ2   . TRP A 1 159 ? -31.68105 17.96263  -4.65971  1.000 46.83544 ? 277 TRP B CZ2   1 
ATOM   1223 C CZ3   . TRP A 1 159 ? -30.48320 15.87028  -4.42823  1.000 44.07557 ? 277 TRP B CZ3   1 
ATOM   1224 C CH2   . TRP A 1 159 ? -30.66337 17.23113  -4.11158  1.000 48.26437 ? 277 TRP B CH2   1 
ATOM   1225 N N     . SER A 1 160 ? -35.95049 12.76050  -8.78113  1.000 38.93076 ? 278 SER B N     1 
ATOM   1226 C CA    . SER A 1 160 ? -36.55596 11.83763  -9.73615  1.000 41.88165 ? 278 SER B CA    1 
ATOM   1227 C C     . SER A 1 160 ? -35.52214 10.94377  -10.39390 1.000 39.92166 ? 278 SER B C     1 
ATOM   1228 O O     . SER A 1 160 ? -34.35989 11.31302  -10.56600 1.000 39.00444 ? 278 SER B O     1 
ATOM   1229 C CB    . SER A 1 160 ? -37.27154 12.61302  -10.84589 1.000 43.77024 ? 278 SER B CB    1 
ATOM   1230 O OG    . SER A 1 160 ? -38.51458 13.08932  -10.40721 1.000 46.18497 ? 278 SER B OG    1 
ATOM   1231 N N     . VAL A 1 161 ? -35.99102 9.77736   -10.82026 1.000 36.94302 ? 279 VAL B N     1 
ATOM   1232 C CA    . VAL A 1 161 ? -35.22335 8.85542   -11.63925 1.000 41.86914 ? 279 VAL B CA    1 
ATOM   1233 C C     . VAL A 1 161 ? -36.21694 8.25136   -12.62676 1.000 45.09908 ? 279 VAL B C     1 
ATOM   1234 O O     . VAL A 1 161 ? -37.41722 8.17915   -12.35106 1.000 44.90316 ? 279 VAL B O     1 
ATOM   1235 C CB    . VAL A 1 161 ? -34.53853 7.81261   -10.72678 1.000 42.86312 ? 279 VAL B CB    1 
ATOM   1236 C CG1   . VAL A 1 161 ? -34.30319 6.52553   -11.41272 1.000 48.86848 ? 279 VAL B CG1   1 
ATOM   1237 C CG2   . VAL A 1 161 ? -33.25345 8.37988   -10.15835 1.000 40.31137 ? 279 VAL B CG2   1 
ATOM   1238 N N     . HIS A 1 162 ? -35.75185 7.87929   -13.81324 1.000 40.84691 ? 280 HIS B N     1 
ATOM   1239 C CA    . HIS A 1 162 ? -36.64829 7.23870   -14.77148 1.000 44.24231 ? 280 HIS B CA    1 
ATOM   1240 C C     . HIS A 1 162 ? -36.21663 5.80862   -15.05992 1.000 41.75963 ? 280 HIS B C     1 
ATOM   1241 O O     . HIS A 1 162 ? -35.03806 5.54125   -15.33730 1.000 37.49283 ? 280 HIS B O     1 
ATOM   1242 C CB    . HIS A 1 162 ? -36.77175 8.03660   -16.07692 1.000 45.56213 ? 280 HIS B CB    1 
ATOM   1243 C CG    . HIS A 1 162 ? -35.47855 8.30247   -16.76613 1.000 46.50727 ? 280 HIS B CG    1 
ATOM   1244 N ND1   . HIS A 1 162 ? -35.01701 7.52454   -17.80931 1.000 54.39882 ? 280 HIS B ND1   1 
ATOM   1245 C CD2   . HIS A 1 162 ? -34.59765 9.32131   -16.64109 1.000 51.95391 ? 280 HIS B CD2   1 
ATOM   1246 C CE1   . HIS A 1 162 ? -33.86634 8.01004   -18.24418 1.000 50.54493 ? 280 HIS B CE1   1 
ATOM   1247 N NE2   . HIS A 1 162 ? -33.57988 9.08941   -17.53783 1.000 53.41706 ? 280 HIS B NE2   1 
ATOM   1248 N N     . ALA A 1 163 ? -37.18262 4.89726   -14.97266 1.000 40.52222 ? 281 ALA B N     1 
ATOM   1249 C CA    . ALA A 1 163 ? -36.98951 3.54080   -15.41242 1.000 39.68546 ? 281 ALA B CA    1 
ATOM   1250 C C     . ALA A 1 163 ? -36.93688 3.51464   -16.93838 1.000 41.19739 ? 281 ALA B C     1 
ATOM   1251 O O     . ALA A 1 163 ? -37.49260 4.39520   -17.60161 1.000 39.45947 ? 281 ALA B O     1 
ATOM   1252 C CB    . ALA A 1 163 ? -38.12100 2.64825   -14.90591 1.000 40.78539 ? 281 ALA B CB    1 
ATOM   1253 N N     . PRO A 1 164 ? -36.29773 2.49611   -17.51796 1.000 43.64539 ? 282 PRO B N     1 
ATOM   1254 C CA    . PRO A 1 164 ? -36.24261 2.41972   -18.98945 1.000 44.05411 ? 282 PRO B CA    1 
ATOM   1255 C C     . PRO A 1 164 ? -37.60843 2.31700   -19.64166 1.000 43.71433 ? 282 PRO B C     1 
ATOM   1256 O O     . PRO A 1 164 ? -37.77415 2.78299   -20.77251 1.000 49.78793 ? 282 PRO B O     1 
ATOM   1257 C CB    . PRO A 1 164 ? -35.40041 1.16040   -19.24491 1.000 47.43720 ? 282 PRO B CB    1 
ATOM   1258 C CG    . PRO A 1 164 ? -34.67491 0.90768   -17.95347 1.000 47.90632 ? 282 PRO B CG    1 
ATOM   1259 C CD    . PRO A 1 164 ? -35.58421 1.37171   -16.88106 1.000 42.83982 ? 282 PRO B CD    1 
ATOM   1260 N N     . SER A 1 165 ? -38.58623 1.71279   -18.96710 1.000 42.58552 ? 283 SER B N     1 
ATOM   1261 C CA    . SER A 1 165 ? -39.94395 1.61379   -19.48547 1.000 46.71776 ? 283 SER B CA    1 
ATOM   1262 C C     . SER A 1 165 ? -40.67405 2.95882   -19.53229 1.000 46.32173 ? 283 SER B C     1 
ATOM   1263 O O     . SER A 1 165 ? -41.74916 3.03704   -20.13599 1.000 45.55213 ? 283 SER B O     1 
ATOM   1264 C CB    . SER A 1 165 ? -40.75411 0.63269   -18.63075 1.000 44.97818 ? 283 SER B CB    1 
ATOM   1265 O OG    . SER A 1 165 ? -40.69120 0.97436   -17.24981 1.000 48.25635 ? 283 SER B OG    1 
ATOM   1266 N N     . SER A 1 166 ? -40.11530 4.00740   -18.93957 1.000 45.42641 ? 284 SER B N     1 
ATOM   1267 C CA    . SER A 1 166 ? -40.83307 5.27095   -18.80640 1.000 45.78307 ? 284 SER B CA    1 
ATOM   1268 C C     . SER A 1 166 ? -40.88941 6.03760   -20.12363 1.000 44.13392 ? 284 SER B C     1 
ATOM   1269 O O     . SER A 1 166 ? -39.93106 6.04382   -20.89474 1.000 44.08455 ? 284 SER B O     1 
ATOM   1270 C CB    . SER A 1 166 ? -40.16656 6.14683   -17.74333 1.000 47.19549 ? 284 SER B CB    1 
ATOM   1271 O OG    . SER A 1 166 ? -40.77377 7.43756   -17.71138 1.000 51.39653 ? 284 SER B OG    1 
ATOM   1272 N N     . ARG A 1 167 ? -42.00340 6.74428   -20.34371 1.000 43.00379 ? 285 ARG B N     1 
ATOM   1273 C CA    . ARG A 1 167 ? -42.17056 7.60415   -21.51284 1.000 42.87168 ? 285 ARG B CA    1 
ATOM   1274 C C     . ARG A 1 167 ? -42.32973 9.07616   -21.12985 1.000 44.85223 ? 285 ARG B C     1 
ATOM   1275 O O     . ARG A 1 167 ? -42.63502 9.90676   -21.99281 1.000 45.17453 ? 285 ARG B O     1 
ATOM   1276 C CB    . ARG A 1 167 ? -43.37258 7.13030   -22.33420 1.000 43.69215 ? 285 ARG B CB    1 
ATOM   1277 C CG    . ARG A 1 167 ? -43.05449 5.96150   -23.28883 1.000 49.34902 ? 285 ARG B CG    1 
ATOM   1278 C CD    . ARG A 1 167 ? -41.57993 5.92502   -23.70135 1.000 51.81085 ? 285 ARG B CD    1 
ATOM   1279 N NE    . ARG A 1 167 ? -41.21363 4.78485   -24.54149 1.000 52.24544 ? 285 ARG B NE    1 
ATOM   1280 C CZ    . ARG A 1 167 ? -40.25555 3.91897   -24.23042 1.000 57.31756 ? 285 ARG B CZ    1 
ATOM   1281 N NH1   . ARG A 1 167 ? -39.57117 4.02005   -23.09660 1.000 54.95809 ? 285 ARG B NH1   1 
ATOM   1282 N NH2   . ARG A 1 167 ? -39.97037 2.93065   -25.07544 1.000 61.69559 ? 285 ARG B NH2   1 
ATOM   1283 N N     . ARG A 1 168 ? -42.11435 9.42626   -19.86728 1.000 43.28158 ? 286 ARG B N     1 
ATOM   1284 C CA    . ARG A 1 168 ? -42.33951 10.77872  -19.37061 1.000 39.44072 ? 286 ARG B CA    1 
ATOM   1285 C C     . ARG A 1 168 ? -41.04943 11.23395  -18.71469 1.000 44.55088 ? 286 ARG B C     1 
ATOM   1286 O O     . ARG A 1 168 ? -40.50602 10.51965  -17.87027 1.000 44.58679 ? 286 ARG B O     1 
ATOM   1287 C CB    . ARG A 1 168 ? -43.50128 10.79632  -18.37308 1.000 41.77215 ? 286 ARG B CB    1 
ATOM   1288 C CG    . ARG A 1 168 ? -43.88634 12.14715  -17.78452 1.000 45.32116 ? 286 ARG B CG    1 
ATOM   1289 C CD    . ARG A 1 168 ? -45.39900 12.18477  -17.52155 1.000 45.40986 ? 286 ARG B CD    1 
ATOM   1290 N NE    . ARG A 1 168 ? -45.74194 11.70282  -16.18598 1.000 42.72995 ? 286 ARG B NE    1 
ATOM   1291 C CZ    . ARG A 1 168 ? -46.96625 11.35188  -15.80999 1.000 44.53241 ? 286 ARG B CZ    1 
ATOM   1292 N NH1   . ARG A 1 168 ? -48.00115 11.45608  -16.63264 1.000 45.05580 ? 286 ARG B NH1   1 
ATOM   1293 N NH2   . ARG A 1 168 ? -47.15920 10.87744  -14.57974 1.000 41.51213 ? 286 ARG B NH2   1 
ATOM   1294 N N     . THR A 1 169 ? -40.53124 12.39236  -19.11173 1.000 36.90398 ? 287 THR B N     1 
ATOM   1295 C CA    . THR A 1 169 ? -39.23605 12.77243  -18.54503 1.000 40.99140 ? 287 THR B CA    1 
ATOM   1296 C C     . THR A 1 169 ? -39.38143 13.22092  -17.10054 1.000 43.18008 ? 287 THR B C     1 
ATOM   1297 O O     . THR A 1 169 ? -40.49202 13.47149  -16.65219 1.000 41.53491 ? 287 THR B O     1 
ATOM   1298 C CB    . THR A 1 169 ? -38.57861 13.89167  -19.33174 1.000 43.70098 ? 287 THR B CB    1 
ATOM   1299 O OG1   . THR A 1 169 ? -39.33351 15.09250  -19.13334 1.000 41.35421 ? 287 THR B OG1   1 
ATOM   1300 C CG2   . THR A 1 169 ? -38.51533 13.52640  -20.81617 1.000 41.42419 ? 287 THR B CG2   1 
HETATM 1301 N N     . TPO A 1 170 ? -38.25463 13.32214  -16.39676 1.000 42.19664 ? 288 TPO B N     1 
HETATM 1302 C CA    . TPO A 1 170 ? -38.19737 13.87168  -15.02789 1.000 49.54265 ? 288 TPO B CA    1 
HETATM 1303 C CB    . TPO A 1 170 ? -36.76950 14.14331  -14.62461 1.000 51.16441 ? 288 TPO B CB    1 
HETATM 1304 C CG2   . TPO A 1 170 ? -36.74709 14.94327  -13.30708 1.000 54.24552 ? 288 TPO B CG2   1 
HETATM 1305 O OG1   . TPO A 1 170 ? -36.01658 12.95033  -14.58473 1.000 50.58835 ? 288 TPO B OG1   1 
HETATM 1306 P P     . TPO A 1 170 ? -34.46773 13.41116  -14.77044 1.000 67.47951 ? 288 TPO B P     1 
HETATM 1307 O O1P   . TPO A 1 170 ? -33.75858 13.44453  -13.46216 1.000 53.35320 ? 288 TPO B O1P   1 
HETATM 1308 O O2P   . TPO A 1 170 ? -33.78304 12.27383  -15.69443 1.000 62.41413 ? 288 TPO B O2P   1 
HETATM 1309 O O3P   . TPO A 1 170 ? -34.20658 14.86621  -15.42803 1.000 47.33714 ? 288 TPO B O3P   1 
HETATM 1310 C C     . TPO A 1 170 ? -38.95757 15.15923  -14.91508 1.000 46.63038 ? 288 TPO B C     1 
HETATM 1311 O O     . TPO A 1 170 ? -39.82922 15.33460  -14.06967 1.000 49.16314 ? 288 TPO B O     1 
ATOM   1312 N N     . LEU A 1 171 ? -38.58716 16.06788  -15.79996 1.000 46.33597 ? 289 LEU B N     1 
ATOM   1313 C CA    . LEU A 1 171 ? -39.09657 17.41763  -15.80261 1.000 44.71426 ? 289 LEU B CA    1 
ATOM   1314 C C     . LEU A 1 171 ? -40.58600 17.47439  -16.08672 1.000 46.09164 ? 289 LEU B C     1 
ATOM   1315 O O     . LEU A 1 171 ? -41.33607 18.19282  -15.40283 1.000 44.35871 ? 289 LEU B O     1 
ATOM   1316 C CB    . LEU A 1 171 ? -38.33275 18.22708  -16.84647 1.000 48.98439 ? 289 LEU B CB    1 
ATOM   1317 C CG    . LEU A 1 171 ? -38.22537 19.73608  -16.72796 1.000 49.32277 ? 289 LEU B CG    1 
ATOM   1318 C CD1   . LEU A 1 171 ? -38.00311 20.16976  -15.28262 1.000 54.03756 ? 289 LEU B CD1   1 
ATOM   1319 C CD2   . LEU A 1 171 ? -37.03715 20.16814  -17.59160 1.000 48.09474 ? 289 LEU B CD2   1 
ATOM   1320 N N     . ALA A 1 172 ? -41.02269 16.74107  -17.11686 1.000 43.15245 ? 290 ALA B N     1 
ATOM   1321 C CA    . ALA A 1 172 ? -42.42211 16.84860  -17.52560 1.000 42.63698 ? 290 ALA B CA    1 
ATOM   1322 C C     . ALA A 1 172 ? -43.34802 16.34253  -16.43081 1.000 36.84419 ? 290 ALA B C     1 
ATOM   1323 O O     . ALA A 1 172 ? -44.36505 16.97718  -16.12214 1.000 37.90043 ? 290 ALA B O     1 
ATOM   1324 C CB    . ALA A 1 172 ? -42.67171 16.08244  -18.82987 1.000 39.61207 ? 290 ALA B CB    1 
ATOM   1325 N N     . GLY A 1 173 ? -43.02463 15.19702  -15.84027 1.000 37.56943 ? 291 GLY B N     1 
ATOM   1326 C CA    . GLY A 1 173 ? -43.90866 14.63175  -14.83049 1.000 38.77662 ? 291 GLY B CA    1 
ATOM   1327 C C     . GLY A 1 173 ? -43.98967 15.50596  -13.59295 1.000 38.73110 ? 291 GLY B C     1 
ATOM   1328 O O     . GLY A 1 173 ? -45.05683 15.64205  -12.98184 1.000 35.74821 ? 291 GLY B O     1 
ATOM   1329 N N     . THR A 1 174 ? -42.86841 16.11726  -13.20885 1.000 36.24691 ? 292 THR B N     1 
ATOM   1330 C CA    . THR A 1 174 ? -42.89776 17.03893  -12.07704 1.000 38.82051 ? 292 THR B CA    1 
ATOM   1331 C C     . THR A 1 174 ? -43.74363 18.26212  -12.40084 1.000 38.03945 ? 292 THR B C     1 
ATOM   1332 O O     . THR A 1 174 ? -44.56515 18.70874  -11.57986 1.000 37.24351 ? 292 THR B O     1 
ATOM   1333 C CB    . THR A 1 174 ? -41.46968 17.45334  -11.70545 1.000 39.32778 ? 292 THR B CB    1 
ATOM   1334 O OG1   . THR A 1 174 ? -40.81059 16.35882  -11.07457 1.000 41.68509 ? 292 THR B OG1   1 
ATOM   1335 C CG2   . THR A 1 174 ? -41.48253 18.63698  -10.72479 1.000 40.80919 ? 292 THR B CG2   1 
ATOM   1336 N N     . LEU A 1 175 ? -43.59881 18.79041  -13.61347 1.000 37.72217 ? 293 LEU B N     1 
ATOM   1337 C CA    . LEU A 1 175 ? -44.40188 19.93998  -13.99997 1.000 38.87597 ? 293 LEU B CA    1 
ATOM   1338 C C     . LEU A 1 175 ? -45.89534 19.62524  -13.95916 1.000 38.69778 ? 293 LEU B C     1 
ATOM   1339 O O     . LEU A 1 175 ? -46.70140 20.45658  -13.51924 1.000 38.49789 ? 293 LEU B O     1 
ATOM   1340 C CB    . LEU A 1 175 ? -43.99085 20.42592  -15.38669 1.000 38.73671 ? 293 LEU B CB    1 
ATOM   1341 C CG    . LEU A 1 175 ? -45.04657 21.43695  -15.83223 1.000 46.58215 ? 293 LEU B CG    1 
ATOM   1342 C CD1   . LEU A 1 175 ? -44.83717 22.67608  -15.01108 1.000 48.38310 ? 293 LEU B CD1   1 
ATOM   1343 C CD2   . LEU A 1 175 ? -44.92793 21.76787  -17.32203 1.000 49.00788 ? 293 LEU B CD2   1 
ATOM   1344 N N     . ASP A 1 176 ? -46.28169 18.42809  -14.40173 1.000 34.07516 ? 294 ASP B N     1 
ATOM   1345 C CA    . ASP A 1 176 ? -47.69196 18.07459  -14.43984 1.000 37.04478 ? 294 ASP B CA    1 
ATOM   1346 C C     . ASP A 1 176 ? -48.35944 18.21341  -13.07690 1.000 34.19687 ? 294 ASP B C     1 
ATOM   1347 O O     . ASP A 1 176 ? -49.58896 18.35444  -13.01565 1.000 35.89981 ? 294 ASP B O     1 
ATOM   1348 C CB    . ASP A 1 176 ? -47.84684 16.63202  -14.94531 1.000 33.99703 ? 294 ASP B CB    1 
ATOM   1349 C CG    . ASP A 1 176 ? -47.80438 16.55070  -16.44855 1.000 41.82657 ? 294 ASP B CG    1 
ATOM   1350 O OD1   . ASP A 1 176 ? -48.28243 17.50167  -17.09614 1.000 43.40031 ? 294 ASP B OD1   1 
ATOM   1351 O OD2   . ASP A 1 176 ? -47.27819 15.54804  -16.98262 1.000 40.79848 ? 294 ASP B OD2   1 
ATOM   1352 N N     . TYR A 1 177 ? -47.58567 18.15410  -11.98912 1.000 31.29873 ? 295 TYR B N     1 
ATOM   1353 C CA    . TYR A 1 177 ? -48.12529 18.09608  -10.63524 1.000 33.71865 ? 295 TYR B CA    1 
ATOM   1354 C C     . TYR A 1 177 ? -47.93100 19.39142  -9.85304  1.000 35.29960 ? 295 TYR B C     1 
ATOM   1355 O O     . TYR A 1 177 ? -48.37922 19.47611  -8.70085  1.000 35.92573 ? 295 TYR B O     1 
ATOM   1356 C CB    . TYR A 1 177 ? -47.51289 16.89849  -9.87343  1.000 32.84734 ? 295 TYR B CB    1 
ATOM   1357 C CG    . TYR A 1 177 ? -48.25680 15.63759  -10.23686 1.000 32.68013 ? 295 TYR B CG    1 
ATOM   1358 C CD1   . TYR A 1 177 ? -48.09633 15.06611  -11.48355 1.000 32.40323 ? 295 TYR B CD1   1 
ATOM   1359 C CD2   . TYR A 1 177 ? -49.18413 15.08098  -9.36903  1.000 31.92940 ? 295 TYR B CD2   1 
ATOM   1360 C CE1   . TYR A 1 177 ? -48.81186 13.92973  -11.85879 1.000 32.53411 ? 295 TYR B CE1   1 
ATOM   1361 C CE2   . TYR A 1 177 ? -49.92918 13.95294  -9.73186  1.000 32.44735 ? 295 TYR B CE2   1 
ATOM   1362 C CZ    . TYR A 1 177 ? -49.73304 13.38923  -10.98082 1.000 32.86267 ? 295 TYR B CZ    1 
ATOM   1363 O OH    . TYR A 1 177 ? -50.48245 12.27189  -11.35636 1.000 33.83810 ? 295 TYR B OH    1 
ATOM   1364 N N     . LEU A 1 178 ? -47.32616 20.41161  -10.45513 1.000 34.84687 ? 296 LEU B N     1 
ATOM   1365 C CA    . LEU A 1 178 ? -47.09229 21.66518  -9.73169  1.000 37.77702 ? 296 LEU B CA    1 
ATOM   1366 C C     . LEU A 1 178 ? -48.38525 22.44905  -9.52902  1.000 40.15847 ? 296 LEU B C     1 
ATOM   1367 O O     . LEU A 1 178 ? -49.18804 22.57658  -10.46219 1.000 35.77403 ? 296 LEU B O     1 
ATOM   1368 C CB    . LEU A 1 178 ? -46.11424 22.56051  -10.46631 1.000 37.01547 ? 296 LEU B CB    1 
ATOM   1369 C CG    . LEU A 1 178 ? -44.65584 22.14114  -10.37230 1.000 42.09103 ? 296 LEU B CG    1 
ATOM   1370 C CD1   . LEU A 1 178 ? -43.84918 23.14622  -11.15577 1.000 44.84292 ? 296 LEU B CD1   1 
ATOM   1371 C CD2   . LEU A 1 178 ? -44.25733 22.09733  -8.90734  1.000 43.58554 ? 296 LEU B CD2   1 
ATOM   1372 N N     . PRO A 1 179 ? -48.57468 23.03853  -8.34827  1.000 35.74361 ? 297 PRO B N     1 
ATOM   1373 C CA    . PRO A 1 179 ? -49.81187 23.75892  -8.05310  1.000 33.46125 ? 297 PRO B CA    1 
ATOM   1374 C C     . PRO A 1 179 ? -49.76336 25.16090  -8.64056  1.000 37.08977 ? 297 PRO B C     1 
ATOM   1375 O O     . PRO A 1 179 ? -48.67552 25.68989  -8.92373  1.000 36.71166 ? 297 PRO B O     1 
ATOM   1376 C CB    . PRO A 1 179 ? -49.83174 23.79645  -6.50965  1.000 34.01209 ? 297 PRO B CB    1 
ATOM   1377 C CG    . PRO A 1 179 ? -48.40681 23.77482  -6.12858  1.000 40.73842 ? 297 PRO B CG    1 
ATOM   1378 C CD    . PRO A 1 179 ? -47.70079 22.92734  -7.16559  1.000 41.68749 ? 297 PRO B CD    1 
ATOM   1379 N N     . PRO A 1 180 ? -50.91592 25.80221  -8.83477  1.000 34.60899 ? 298 PRO B N     1 
ATOM   1380 C CA    . PRO A 1 180 ? -50.89476 27.14339  -9.44663  1.000 36.40412 ? 298 PRO B CA    1 
ATOM   1381 C C     . PRO A 1 180 ? -50.01507 28.11292  -8.68365  1.000 40.21646 ? 298 PRO B C     1 
ATOM   1382 O O     . PRO A 1 180 ? -49.27020 28.87930  -9.30596  1.000 41.07868 ? 298 PRO B O     1 
ATOM   1383 C CB    . PRO A 1 180 ? -52.37356 27.56203  -9.43149  1.000 37.20047 ? 298 PRO B CB    1 
ATOM   1384 C CG    . PRO A 1 180 ? -53.13241 26.29392  -9.36053  1.000 38.63588 ? 298 PRO B CG    1 
ATOM   1385 C CD    . PRO A 1 180 ? -52.28365 25.31655  -8.59675  1.000 37.15388 ? 298 PRO B CD    1 
ATOM   1386 N N     . GLU A 1 181 ? -50.03237 28.05297  -7.34600  1.000 39.19757 ? 299 GLU B N     1 
ATOM   1387 C CA    . GLU A 1 181 ? -49.28398 29.02911  -6.55814  1.000 39.41572 ? 299 GLU B CA    1 
ATOM   1388 C C     . GLU A 1 181 ? -47.78189 28.90920  -6.78449  1.000 41.46590 ? 299 GLU B C     1 
ATOM   1389 O O     . GLU A 1 181 ? -47.07025 29.92125  -6.71869  1.000 45.29427 ? 299 GLU B O     1 
ATOM   1390 C CB    . GLU A 1 181 ? -49.62734 28.89950  -5.06477  1.000 39.71617 ? 299 GLU B CB    1 
ATOM   1391 C CG    . GLU A 1 181 ? -49.40406 27.53317  -4.44479  1.000 39.77156 ? 299 GLU B CG    1 
ATOM   1392 C CD    . GLU A 1 181 ? -50.68481 26.68731  -4.38742  1.000 39.69480 ? 299 GLU B CD    1 
ATOM   1393 O OE1   . GLU A 1 181 ? -51.51655 26.82511  -5.31494  1.000 38.31994 ? 299 GLU B OE1   1 
ATOM   1394 O OE2   . GLU A 1 181 ? -50.85097 25.90234  -3.41618  1.000 34.36537 ? 299 GLU B OE2   1 
ATOM   1395 N N     . MET A 1 182 ? -47.26573 27.70592  -7.07679  1.000 39.25398 ? 300 MET B N     1 
ATOM   1396 C CA    . MET A 1 182 ? -45.84892 27.65149  -7.40148  1.000 44.47274 ? 300 MET B CA    1 
ATOM   1397 C C     . MET A 1 182 ? -45.58254 27.95865  -8.86495  1.000 48.33181 ? 300 MET B C     1 
ATOM   1398 O O     . MET A 1 182 ? -44.53643 28.53291  -9.18009  1.000 47.93718 ? 300 MET B O     1 
ATOM   1399 C CB    . MET A 1 182 ? -45.19074 26.32406  -6.99560  1.000 46.61413 ? 300 MET B CB    1 
ATOM   1400 C CG    . MET A 1 182 ? -45.47172 25.86307  -5.55893  1.000 44.62876 ? 300 MET B CG    1 
ATOM   1401 S SD    . MET A 1 182 ? -44.89423 24.18119  -5.25411  1.000 47.16080 ? 300 MET B SD    1 
ATOM   1402 C CE    . MET A 1 182 ? -43.13818 24.38628  -5.56740  1.000 51.14436 ? 300 MET B CE    1 
ATOM   1403 N N     . ILE A 1 183 ? -46.51139 27.62959  -9.76321  1.000 43.37999 ? 301 ILE B N     1 
ATOM   1404 C CA    . ILE A 1 183 ? -46.40635 28.12029  -11.13860 1.000 47.17744 ? 301 ILE B CA    1 
ATOM   1405 C C     . ILE A 1 183 ? -46.36761 29.64256  -11.15744 1.000 48.20032 ? 301 ILE B C     1 
ATOM   1406 O O     . ILE A 1 183 ? -45.55170 30.24877  -11.86468 1.000 49.86763 ? 301 ILE B O     1 
ATOM   1407 C CB    . ILE A 1 183 ? -47.56828 27.57320  -11.99592 1.000 44.42318 ? 301 ILE B CB    1 
ATOM   1408 C CG1   . ILE A 1 183 ? -47.49459 26.03839  -12.05588 1.000 44.05843 ? 301 ILE B CG1   1 
ATOM   1409 C CG2   . ILE A 1 183 ? -47.65766 28.27119  -13.37159 1.000 43.43933 ? 301 ILE B CG2   1 
ATOM   1410 C CD1   . ILE A 1 183 ? -46.38700 25.50545  -12.92347 1.000 46.54219 ? 301 ILE B CD1   1 
ATOM   1411 N N     . GLU A 1 184 ? -47.23285 30.28455  -10.36712 1.000 45.19570 ? 302 GLU B N     1 
ATOM   1412 C CA    . GLU A 1 184 ? -47.37097 31.73725  -10.40464 1.000 48.92278 ? 302 GLU B CA    1 
ATOM   1413 C C     . GLU A 1 184 ? -46.29543 32.45744  -9.59819  1.000 48.02441 ? 302 GLU B C     1 
ATOM   1414 O O     . GLU A 1 184 ? -46.23040 33.68981  -9.64714  1.000 51.74934 ? 302 GLU B O     1 
ATOM   1415 C CB    . GLU A 1 184 ? -48.76209 32.13670  -9.89863  1.000 50.00974 ? 302 GLU B CB    1 
ATOM   1416 C CG    . GLU A 1 184 ? -49.88786 31.79865  -10.87104 1.000 48.95181 ? 302 GLU B CG    1 
ATOM   1417 C CD    . GLU A 1 184 ? -51.22494 31.60373  -10.19149 1.000 51.15929 ? 302 GLU B CD    1 
ATOM   1418 O OE1   . GLU A 1 184 ? -51.36060 31.96716  -9.00378  1.000 51.19501 ? 302 GLU B OE1   1 
ATOM   1419 O OE2   . GLU A 1 184 ? -52.14596 31.06408  -10.84751 1.000 44.96189 ? 302 GLU B OE2   1 
ATOM   1420 N N     . GLY A 1 185 ? -45.47053 31.72476  -8.85408  1.000 48.63030 ? 303 GLY B N     1 
ATOM   1421 C CA    . GLY A 1 185 ? -44.43096 32.31132  -8.02473  1.000 49.73410 ? 303 GLY B CA    1 
ATOM   1422 C C     . GLY A 1 185 ? -44.88386 32.94291  -6.72454  1.000 53.19491 ? 303 GLY B C     1 
ATOM   1423 O O     . GLY A 1 185 ? -44.19480 33.83755  -6.21932  1.000 54.02843 ? 303 GLY B O     1 
ATOM   1424 N N     . ARG A 1 186 ? -46.01528 32.51426  -6.15765  1.000 45.77603 ? 304 ARG B N     1 
ATOM   1425 C CA    . ARG A 1 186 ? -46.52075 33.07275  -4.91195  1.000 48.26035 ? 304 ARG B CA    1 
ATOM   1426 C C     . ARG A 1 186 ? -46.04380 32.23925  -3.72267  1.000 47.42499 ? 304 ARG B C     1 
ATOM   1427 O O     . ARG A 1 186 ? -45.47028 31.16265  -3.88208  1.000 44.95111 ? 304 ARG B O     1 
ATOM   1428 C CB    . ARG A 1 186 ? -48.04854 33.12742  -4.91780  1.000 48.40736 ? 304 ARG B CB    1 
ATOM   1429 C CG    . ARG A 1 186 ? -48.67630 33.90464  -6.03933  1.000 54.87507 ? 304 ARG B CG    1 
ATOM   1430 C CD    . ARG A 1 186 ? -50.17779 33.60784  -6.04906  1.000 61.07368 ? 304 ARG B CD    1 
ATOM   1431 N NE    . ARG A 1 186 ? -50.88021 33.98002  -7.27511  1.000 64.74550 ? 304 ARG B NE    1 
ATOM   1432 C CZ    . ARG A 1 186 ? -50.84964 35.17439  -7.85928  1.000 73.50497 ? 304 ARG B CZ    1 
ATOM   1433 N NH1   . ARG A 1 186 ? -50.14691 36.18233  -7.35876  1.000 71.60002 ? 304 ARG B NH1   1 
ATOM   1434 N NH2   . ARG A 1 186 ? -51.56268 35.37048  -8.96589  1.000 70.19526 ? 304 ARG B NH2   1 
ATOM   1435 N N     . MET A 1 187 ? -46.29108 32.74937  -2.51175  1.000 48.21706 ? 305 MET B N     1 
ATOM   1436 C CA    . MET A 1 187 ? -46.12433 31.92643  -1.31512  1.000 49.72074 ? 305 MET B CA    1 
ATOM   1437 C C     . MET A 1 187 ? -46.93594 30.64774  -1.42348  1.000 47.56314 ? 305 MET B C     1 
ATOM   1438 O O     . MET A 1 187 ? -48.03966 30.63406  -1.97380  1.000 47.61578 ? 305 MET B O     1 
ATOM   1439 C CB    . MET A 1 187 ? -46.58878 32.63081  -0.03526  1.000 51.34046 ? 305 MET B CB    1 
ATOM   1440 C CG    . MET A 1 187 ? -45.92630 33.89738  0.38318   1.000 58.80547 ? 305 MET B CG    1 
ATOM   1441 S SD    . MET A 1 187 ? -46.26970 34.04027  2.16270   1.000 63.85665 ? 305 MET B SD    1 
ATOM   1442 C CE    . MET A 1 187 ? -48.03722 34.36529  2.12653   1.000 57.15140 ? 305 MET B CE    1 
ATOM   1443 N N     . HIS A 1 188 ? -46.41536 29.57113  -0.84813  1.000 44.96576 ? 306 HIS B N     1 
ATOM   1444 C CA    . HIS A 1 188 ? -47.22441 28.36679  -0.75019  1.000 46.12502 ? 306 HIS B CA    1 
ATOM   1445 C C     . HIS A 1 188 ? -47.08908 27.79143  0.65477   1.000 47.01385 ? 306 HIS B C     1 
ATOM   1446 O O     . HIS A 1 188 ? -46.30330 28.27519  1.47893   1.000 49.56405 ? 306 HIS B O     1 
ATOM   1447 C CB    . HIS A 1 188 ? -46.85494 27.35565  -1.84590  1.000 43.34315 ? 306 HIS B CB    1 
ATOM   1448 C CG    . HIS A 1 188 ? -45.44632 26.86085  -1.77214  1.000 49.05218 ? 306 HIS B CG    1 
ATOM   1449 N ND1   . HIS A 1 188 ? -44.45402 27.30011  -2.62309  1.000 49.86388 ? 306 HIS B ND1   1 
ATOM   1450 C CD2   . HIS A 1 188 ? -44.86575 25.95202  -0.95271  1.000 52.53271 ? 306 HIS B CD2   1 
ATOM   1451 C CE1   . HIS A 1 188 ? -43.32458 26.67836  -2.33504  1.000 49.13195 ? 306 HIS B CE1   1 
ATOM   1452 N NE2   . HIS A 1 188 ? -43.54362 25.86288  -1.31830  1.000 52.20581 ? 306 HIS B NE2   1 
ATOM   1453 N N     . ASP A 1 189 ? -47.90842 26.78514  0.93646   1.000 44.29488 ? 307 ASP B N     1 
ATOM   1454 C CA    . ASP A 1 189 ? -47.98417 26.16893  2.25319   1.000 43.76757 ? 307 ASP B CA    1 
ATOM   1455 C C     . ASP A 1 189 ? -48.23784 24.67809  2.02959   1.000 43.70962 ? 307 ASP B C     1 
ATOM   1456 O O     . ASP A 1 189 ? -48.05104 24.15719  0.92483   1.000 42.18337 ? 307 ASP B O     1 
ATOM   1457 C CB    . ASP A 1 189 ? -49.05312 26.86884  3.11379   1.000 43.05172 ? 307 ASP B CB    1 
ATOM   1458 C CG    . ASP A 1 189 ? -50.38547 27.02613  2.38402   1.000 47.78938 ? 307 ASP B CG    1 
ATOM   1459 O OD1   . ASP A 1 189 ? -50.74132 26.10842  1.60818   1.000 43.04420 ? 307 ASP B OD1   1 
ATOM   1460 O OD2   . ASP A 1 189 ? -51.09550 28.03605  2.60838   1.000 44.29386 ? 307 ASP B OD2   1 
ATOM   1461 N N     . GLU A 1 190 ? -48.66739 23.96563  3.08025   1.000 43.37052 ? 308 GLU B N     1 
ATOM   1462 C CA    . GLU A 1 190 ? -48.88259 22.52599  2.94582   1.000 43.42752 ? 308 GLU B CA    1 
ATOM   1463 C C     . GLU A 1 190 ? -50.06952 22.19187  2.05377   1.000 39.79068 ? 308 GLU B C     1 
ATOM   1464 O O     . GLU A 1 190 ? -50.22628 21.02613  1.66684   1.000 37.92807 ? 308 GLU B O     1 
ATOM   1465 C CB    . GLU A 1 190 ? -49.04965 21.87209  4.32338   1.000 38.01987 ? 308 GLU B CB    1 
ATOM   1466 C CG    . GLU A 1 190 ? -50.40387 22.09213  5.02425   1.000 41.85638 ? 308 GLU B CG    1 
ATOM   1467 C CD    . GLU A 1 190 ? -50.49444 23.40175  5.81705   1.000 47.63396 ? 308 GLU B CD    1 
ATOM   1468 O OE1   . GLU A 1 190 ? -49.70908 24.33936  5.55140   1.000 45.78950 ? 308 GLU B OE1   1 
ATOM   1469 O OE2   . GLU A 1 190 ? -51.32766 23.46997  6.75349   1.000 48.70452 ? 308 GLU B OE2   1 
ATOM   1470 N N     . LYS A 1 191 ? -50.88652 23.17655  1.68072   1.000 36.19343 ? 309 LYS B N     1 
ATOM   1471 C CA    . LYS A 1 191 ? -51.95570 22.89286  0.73112   1.000 35.17863 ? 309 LYS B CA    1 
ATOM   1472 C C     . LYS A 1 191 ? -51.43211 22.49139  -0.65373  1.000 36.83181 ? 309 LYS B C     1 
ATOM   1473 O O     . LYS A 1 191 ? -52.22566 22.02077  -1.47781  1.000 37.61198 ? 309 LYS B O     1 
ATOM   1474 C CB    . LYS A 1 191 ? -52.88893 24.09663  0.60404   1.000 41.31393 ? 309 LYS B CB    1 
ATOM   1475 C CG    . LYS A 1 191 ? -53.66109 24.45081  1.87426   1.000 38.26148 ? 309 LYS B CG    1 
ATOM   1476 C CD    . LYS A 1 191 ? -54.71582 23.38568  2.21052   1.000 42.06675 ? 309 LYS B CD    1 
ATOM   1477 C CE    . LYS A 1 191 ? -55.70396 23.93167  3.27459   1.000 42.98367 ? 309 LYS B CE    1 
ATOM   1478 N NZ    . LYS A 1 191 ? -56.74082 22.93208  3.66615   1.000 47.11336 ? 309 LYS B NZ    1 
ATOM   1479 N N     . VAL A 1 192 ? -50.12957 22.63549  -0.93250  1.000 37.73266 ? 310 VAL B N     1 
ATOM   1480 C CA    . VAL A 1 192 ? -49.61177 22.13855  -2.21091  1.000 35.90613 ? 310 VAL B CA    1 
ATOM   1481 C C     . VAL A 1 192 ? -49.80224 20.63089  -2.30022  1.000 36.79194 ? 310 VAL B C     1 
ATOM   1482 O O     . VAL A 1 192 ? -49.96433 20.07545  -3.39647  1.000 37.35834 ? 310 VAL B O     1 
ATOM   1483 C CB    . VAL A 1 192 ? -48.12360 22.51773  -2.42023  1.000 39.95365 ? 310 VAL B CB    1 
ATOM   1484 C CG1   . VAL A 1 192 ? -47.92993 24.04031  -2.45540  1.000 40.96561 ? 310 VAL B CG1   1 
ATOM   1485 C CG2   . VAL A 1 192 ? -47.24499 21.87560  -1.38029  1.000 40.19050 ? 310 VAL B CG2   1 
ATOM   1486 N N     . ASP A 1 193 ? -49.78608 19.94409  -1.15923  1.000 34.73462 ? 311 ASP B N     1 
ATOM   1487 C CA    . ASP A 1 193 ? -49.90130 18.49329  -1.16841  1.000 36.83507 ? 311 ASP B CA    1 
ATOM   1488 C C     . ASP A 1 193 ? -51.33628 18.04653  -1.40645  1.000 36.26792 ? 311 ASP B C     1 
ATOM   1489 O O     . ASP A 1 193 ? -51.56120 16.95109  -1.93971  1.000 34.05358 ? 311 ASP B O     1 
ATOM   1490 C CB    . ASP A 1 193 ? -49.37301 17.92727  0.13973   1.000 34.26938 ? 311 ASP B CB    1 
ATOM   1491 C CG    . ASP A 1 193 ? -47.85822 18.09064  0.26709   1.000 39.77576 ? 311 ASP B CG    1 
ATOM   1492 O OD1   . ASP A 1 193 ? -47.15863 17.89195  -0.73685  1.000 40.53483 ? 311 ASP B OD1   1 
ATOM   1493 O OD2   . ASP A 1 193 ? -47.36784 18.40586  1.36966   1.000 41.00068 ? 311 ASP B OD2   1 
ATOM   1494 N N     . LEU A 1 194 ? -52.30324 18.89737  -1.04785  1.000 35.48329 ? 312 LEU B N     1 
ATOM   1495 C CA    . LEU A 1 194 ? -53.69659 18.60711  -1.34756  1.000 32.52311 ? 312 LEU B CA    1 
ATOM   1496 C C     . LEU A 1 194 ? -53.93853 18.73775  -2.84193  1.000 35.61512 ? 312 LEU B C     1 
ATOM   1497 O O     . LEU A 1 194 ? -54.62548 17.90386  -3.44510  1.000 31.84629 ? 312 LEU B O     1 
ATOM   1498 C CB    . LEU A 1 194 ? -54.61399 19.55118  -0.54838  1.000 35.30769 ? 312 LEU B CB    1 
ATOM   1499 C CG    . LEU A 1 194 ? -54.94407 19.16476  0.90489   1.000 37.68103 ? 312 LEU B CG    1 
ATOM   1500 C CD1   . LEU A 1 194 ? -55.74332 17.85364  1.00463   1.000 39.09000 ? 312 LEU B CD1   1 
ATOM   1501 C CD2   . LEU A 1 194 ? -53.67259 19.08323  1.76822   1.000 38.56526 ? 312 LEU B CD2   1 
ATOM   1502 N N     . TRP A 1 195 ? -53.34420 19.75992  -3.46289  1.000 32.49858 ? 313 TRP B N     1 
ATOM   1503 C CA    . TRP A 1 195 ? -53.43071 19.90553  -4.91312  1.000 31.12837 ? 313 TRP B CA    1 
ATOM   1504 C C     . TRP A 1 195 ? -52.86633 18.67394  -5.62619  1.000 32.44877 ? 313 TRP B C     1 
ATOM   1505 O O     . TRP A 1 195 ? -53.49345 18.13408  -6.54603  1.000 34.40025 ? 313 TRP B O     1 
ATOM   1506 C CB    . TRP A 1 195 ? -52.67722 21.16309  -5.35556  1.000 33.76705 ? 313 TRP B CB    1 
ATOM   1507 C CG    . TRP A 1 195 ? -52.57745 21.28096  -6.85464  1.000 33.19080 ? 313 TRP B CG    1 
ATOM   1508 C CD1   . TRP A 1 195 ? -51.60683 20.72155  -7.65183  1.000 35.97019 ? 313 TRP B CD1   1 
ATOM   1509 C CD2   . TRP A 1 195 ? -53.45484 21.98953  -7.72743  1.000 33.24268 ? 313 TRP B CD2   1 
ATOM   1510 N NE1   . TRP A 1 195 ? -51.84762 21.02825  -8.95890  1.000 30.75420 ? 313 TRP B NE1   1 
ATOM   1511 C CE2   . TRP A 1 195 ? -52.96777 21.80883  -9.04069  1.000 34.32400 ? 313 TRP B CE2   1 
ATOM   1512 C CE3   . TRP A 1 195 ? -54.60471 22.76406  -7.53064  1.000 33.45257 ? 313 TRP B CE3   1 
ATOM   1513 C CZ2   . TRP A 1 195 ? -53.58214 22.37250  -10.14961 1.000 32.63605 ? 313 TRP B CZ2   1 
ATOM   1514 C CZ3   . TRP A 1 195 ? -55.22604 23.32062  -8.64196  1.000 34.96054 ? 313 TRP B CZ3   1 
ATOM   1515 C CH2   . TRP A 1 195 ? -54.70990 23.11512  -9.94028  1.000 33.19069 ? 313 TRP B CH2   1 
ATOM   1516 N N     . SER A 1 196 ? -51.67027 18.23110  -5.22204  1.000 33.22487 ? 314 SER B N     1 
ATOM   1517 C CA    . SER A 1 196 ? -51.06146 17.06016  -5.85857  1.000 37.19980 ? 314 SER B CA    1 
ATOM   1518 C C     . SER A 1 196 ? -51.96346 15.83657  -5.73847  1.000 33.54960 ? 314 SER B C     1 
ATOM   1519 O O     . SER A 1 196 ? -52.04732 15.01985  -6.66968  1.000 34.32476 ? 314 SER B O     1 
ATOM   1520 C CB    . SER A 1 196 ? -49.69796 16.76929  -5.23319  1.000 34.20196 ? 314 SER B CB    1 
ATOM   1521 O OG    . SER A 1 196 ? -48.78157 17.82038  -5.52219  1.000 38.57651 ? 314 SER B OG    1 
ATOM   1522 N N     . LEU A 1 197 ? -52.63956 15.69004  -4.59795  1.000 32.19775 ? 315 LEU B N     1 
ATOM   1523 C CA    . LEU A 1 197 ? -53.56580 14.57045  -4.42325  1.000 34.58969 ? 315 LEU B CA    1 
ATOM   1524 C C     . LEU A 1 197 ? -54.69116 14.61863  -5.44546  1.000 35.43938 ? 315 LEU B C     1 
ATOM   1525 O O     . LEU A 1 197 ? -55.19162 13.57413  -5.88226  1.000 33.54454 ? 315 LEU B O     1 
ATOM   1526 C CB    . LEU A 1 197 ? -54.15232 14.60004  -3.00991  1.000 38.75080 ? 315 LEU B CB    1 
ATOM   1527 C CG    . LEU A 1 197 ? -53.45496 13.86137  -1.88790  1.000 39.39100 ? 315 LEU B CG    1 
ATOM   1528 C CD1   . LEU A 1 197 ? -54.32488 13.96652  -0.60175  1.000 38.60400 ? 315 LEU B CD1   1 
ATOM   1529 C CD2   . LEU A 1 197 ? -53.18972 12.40203  -2.24221  1.000 36.93164 ? 315 LEU B CD2   1 
ATOM   1530 N N     . GLY A 1 198 ? -55.16703 15.82350  -5.76974  1.000 33.48395 ? 316 GLY B N     1 
ATOM   1531 C CA    . GLY A 1 198 ? -56.21376 15.95033  -6.76667  1.000 33.94105 ? 316 GLY B CA    1 
ATOM   1532 C C     . GLY A 1 198 ? -55.72245 15.59943  -8.15623  1.000 31.95857 ? 316 GLY B C     1 
ATOM   1533 O O     . GLY A 1 198 ? -56.41886 14.92672  -8.91984  1.000 31.48543 ? 316 GLY B O     1 
ATOM   1534 N N     . VAL A 1 199 ? -54.51633 16.03651  -8.50381  1.000 33.49923 ? 317 VAL B N     1 
ATOM   1535 C CA    . VAL A 1 199 ? -53.96682 15.66090  -9.81060  1.000 31.66287 ? 317 VAL B CA    1 
ATOM   1536 C C     . VAL A 1 199 ? -53.83713 14.14768  -9.89469  1.000 30.68651 ? 317 VAL B C     1 
ATOM   1537 O O     . VAL A 1 199 ? -54.18091 13.53197  -10.91882 1.000 32.21950 ? 317 VAL B O     1 
ATOM   1538 C CB    . VAL A 1 199 ? -52.61860 16.35766  -10.05190 1.000 32.59355 ? 317 VAL B CB    1 
ATOM   1539 C CG1   . VAL A 1 199 ? -52.07201 16.06902  -11.47499 1.000 33.03492 ? 317 VAL B CG1   1 
ATOM   1540 C CG2   . VAL A 1 199 ? -52.72278 17.86548  -9.81455  1.000 31.34297 ? 317 VAL B CG2   1 
ATOM   1541 N N     . LEU A 1 200 ? -53.33391 13.53689  -8.82408  1.000 30.28206 ? 318 LEU B N     1 
ATOM   1542 C CA    . LEU A 1 200 ? -53.09506 12.09640  -8.80764  1.000 31.19740 ? 318 LEU B CA    1 
ATOM   1543 C C     . LEU A 1 200 ? -54.40269 11.31669  -8.92188  1.000 31.73769 ? 318 LEU B C     1 
ATOM   1544 O O     . LEU A 1 200 ? -54.49524 10.34252  -9.68437  1.000 34.79010 ? 318 LEU B O     1 
ATOM   1545 C CB    . LEU A 1 200 ? -52.39568 11.71923  -7.51669  1.000 32.04171 ? 318 LEU B CB    1 
ATOM   1546 C CG    . LEU A 1 200 ? -51.67703 10.37871  -7.50075  1.000 38.07803 ? 318 LEU B CG    1 
ATOM   1547 C CD1   . LEU A 1 200 ? -50.47191 10.40121  -8.47267  1.000 37.37709 ? 318 LEU B CD1   1 
ATOM   1548 C CD2   . LEU A 1 200 ? -51.22573 10.17330  -6.09416  1.000 38.34279 ? 318 LEU B CD2   1 
ATOM   1549 N N     . CYS A 1 201 ? -55.38808 11.67221  -8.09640  1.000 32.91376 ? 319 CYS B N     1 
ATOM   1550 C CA    . CYS A 1 201 ? -56.70359 11.02211  -8.19246  1.000 31.89362 ? 319 CYS B CA    1 
ATOM   1551 C C     . CYS A 1 201 ? -57.23471 11.05957  -9.62407  1.000 33.94455 ? 319 CYS B C     1 
ATOM   1552 O O     . CYS A 1 201 ? -57.77856 10.06408  -10.12713 1.000 36.25042 ? 319 CYS B O     1 
ATOM   1553 C CB    . CYS A 1 201 ? -57.68927 11.70428  -7.24518  1.000 35.72412 ? 319 CYS B CB    1 
ATOM   1554 S SG    . CYS A 1 201 ? -59.21844 10.74115  -6.90165  1.000 38.98461 ? 319 CYS B SG    1 
ATOM   1555 N N     . TYR A 1 202 ? -57.11743 12.21028  -10.28987 1.000 32.88716 ? 320 TYR B N     1 
ATOM   1556 C CA    . TYR A 1 202 ? -57.57288 12.31136  -11.67456 1.000 33.34290 ? 320 TYR B CA    1 
ATOM   1557 C C     . TYR A 1 202 ? -56.75170 11.40088  -12.59420 1.000 35.70425 ? 320 TYR B C     1 
ATOM   1558 O O     . TYR A 1 202 ? -57.31441 10.68008  -13.43370 1.000 33.12505 ? 320 TYR B O     1 
ATOM   1559 C CB    . TYR A 1 202 ? -57.49740 13.77170  -12.14440 1.000 32.20508 ? 320 TYR B CB    1 
ATOM   1560 C CG    . TYR A 1 202 ? -57.99413 14.03282  -13.54827 1.000 33.54539 ? 320 TYR B CG    1 
ATOM   1561 C CD1   . TYR A 1 202 ? -57.27313 13.60194  -14.65501 1.000 34.00474 ? 320 TYR B CD1   1 
ATOM   1562 C CD2   . TYR A 1 202 ? -59.17310 14.75801  -13.77310 1.000 35.38892 ? 320 TYR B CD2   1 
ATOM   1563 C CE1   . TYR A 1 202 ? -57.72233 13.85208  -15.94799 1.000 34.57237 ? 320 TYR B CE1   1 
ATOM   1564 C CE2   . TYR A 1 202 ? -59.61700 15.02277  -15.05645 1.000 33.77400 ? 320 TYR B CE2   1 
ATOM   1565 C CZ    . TYR A 1 202 ? -58.89413 14.56324  -16.14130 1.000 37.29136 ? 320 TYR B CZ    1 
ATOM   1566 O OH    . TYR A 1 202 ? -59.33321 14.81890  -17.42573 1.000 36.78873 ? 320 TYR B OH    1 
ATOM   1567 N N     . GLU A 1 203 ? -55.41339 11.45663  -12.49590 1.000 32.69302 ? 321 GLU B N     1 
ATOM   1568 C CA    . GLU A 1 203 ? -54.60926 10.64376  -13.40421 1.000 31.64107 ? 321 GLU B CA    1 
ATOM   1569 C C     . GLU A 1 203 ? -54.88800 9.15277   -13.17973 1.000 31.26085 ? 321 GLU B C     1 
ATOM   1570 O O     . GLU A 1 203 ? -54.94586 8.38422   -14.14234 1.000 34.60482 ? 321 GLU B O     1 
ATOM   1571 C CB    . GLU A 1 203 ? -53.11087 10.95145  -13.24727 1.000 33.79357 ? 321 GLU B CB    1 
ATOM   1572 C CG    . GLU A 1 203 ? -52.26231 10.08994  -14.19305 1.000 34.32115 ? 321 GLU B CG    1 
ATOM   1573 C CD    . GLU A 1 203 ? -50.82206 10.60241  -14.41420 1.000 38.47267 ? 321 GLU B CD    1 
ATOM   1574 O OE1   . GLU A 1 203 ? -50.29139 11.30383  -13.54112 1.000 39.14216 ? 321 GLU B OE1   1 
ATOM   1575 O OE2   . GLU A 1 203 ? -50.21341 10.26117  -15.46245 1.000 40.13278 ? 321 GLU B OE2   1 
ATOM   1576 N N     . PHE A 1 204 ? -55.10863 8.75629   -11.92074 1.000 31.28668 ? 322 PHE B N     1 
ATOM   1577 C CA    . PHE A 1 204 ? -55.45676 7.37169   -11.57368 1.000 35.13966 ? 322 PHE B CA    1 
ATOM   1578 C C     . PHE A 1 204 ? -56.73899 6.93058   -12.27836 1.000 35.15092 ? 322 PHE B C     1 
ATOM   1579 O O     . PHE A 1 204 ? -56.80479 5.84144   -12.86108 1.000 36.66862 ? 322 PHE B O     1 
ATOM   1580 C CB    . PHE A 1 204 ? -55.65649 7.24389   -10.06058 1.000 33.53707 ? 322 PHE B CB    1 
ATOM   1581 C CG    . PHE A 1 204 ? -54.39493 7.14729   -9.25491  1.000 32.81888 ? 322 PHE B CG    1 
ATOM   1582 C CD1   . PHE A 1 204 ? -53.16502 7.00021   -9.85737  1.000 35.44911 ? 322 PHE B CD1   1 
ATOM   1583 C CD2   . PHE A 1 204 ? -54.45143 7.21225   -7.86583  1.000 37.17954 ? 322 PHE B CD2   1 
ATOM   1584 C CE1   . PHE A 1 204 ? -52.01626 6.90214   -9.08828  1.000 38.23258 ? 322 PHE B CE1   1 
ATOM   1585 C CE2   . PHE A 1 204 ? -53.30181 7.13404   -7.10062  1.000 38.00305 ? 322 PHE B CE2   1 
ATOM   1586 C CZ    . PHE A 1 204 ? -52.09190 6.96255   -7.71670  1.000 37.16507 ? 322 PHE B CZ    1 
ATOM   1587 N N     . LEU A 1 205 ? -57.79136 7.75646   -12.19957 1.000 36.16685 ? 323 LEU B N     1 
ATOM   1588 C CA    . LEU A 1 205 ? -59.07631 7.36034   -12.76571 1.000 35.52354 ? 323 LEU B CA    1 
ATOM   1589 C C     . LEU A 1 205 ? -59.10867 7.50464   -14.27532 1.000 36.82422 ? 323 LEU B C     1 
ATOM   1590 O O     . LEU A 1 205 ? -59.84309 6.77915   -14.94526 1.000 37.13245 ? 323 LEU B O     1 
ATOM   1591 C CB    . LEU A 1 205 ? -60.20975 8.19515   -12.15405 1.000 33.04804 ? 323 LEU B CB    1 
ATOM   1592 C CG    . LEU A 1 205 ? -60.45133 7.95584   -10.67051 1.000 33.74201 ? 323 LEU B CG    1 
ATOM   1593 C CD1   . LEU A 1 205 ? -61.40073 9.03200   -10.16892 1.000 40.05663 ? 323 LEU B CD1   1 
ATOM   1594 C CD2   . LEU A 1 205 ? -61.07551 6.56697   -10.49850 1.000 37.23817 ? 323 LEU B CD2   1 
ATOM   1595 N N     . VAL A 1 206 ? -58.33275 8.42920   -14.83136 1.000 35.78401 ? 324 VAL B N     1 
ATOM   1596 C CA    . VAL A 1 206 ? -58.48148 8.81018   -16.22905 1.000 33.83967 ? 324 VAL B CA    1 
ATOM   1597 C C     . VAL A 1 206 ? -57.37042 8.20990   -17.08039 1.000 36.62388 ? 324 VAL B C     1 
ATOM   1598 O O     . VAL A 1 206 ? -57.57537 7.92119   -18.26493 1.000 37.26980 ? 324 VAL B O     1 
ATOM   1599 C CB    . VAL A 1 206 ? -58.53115 10.34896  -16.36203 1.000 35.97077 ? 324 VAL B CB    1 
ATOM   1600 C CG1   . VAL A 1 206 ? -58.53500 10.76280  -17.82702 1.000 35.66397 ? 324 VAL B CG1   1 
ATOM   1601 C CG2   . VAL A 1 206 ? -59.80693 10.86148  -15.71207 1.000 34.81944 ? 324 VAL B CG2   1 
ATOM   1602 N N     . GLY A 1 207 ? -56.19036 8.02798   -16.49056 1.000 33.71767 ? 325 GLY B N     1 
ATOM   1603 C CA    . GLY A 1 207 ? -55.03321 7.52450   -17.20878 1.000 39.46565 ? 325 GLY B CA    1 
ATOM   1604 C C     . GLY A 1 207 ? -54.08854 8.58101   -17.73792 1.000 41.88154 ? 325 GLY B C     1 
ATOM   1605 O O     . GLY A 1 207 ? -53.02687 8.23091   -18.28266 1.000 36.13571 ? 325 GLY B O     1 
ATOM   1606 N N     . LYS A 1 208 ? -54.44780 9.85767   -17.61613 1.000 36.03015 ? 326 LYS B N     1 
ATOM   1607 C CA    . LYS A 1 208 ? -53.67215 11.00173  -18.06101 1.000 39.30572 ? 326 LYS B CA    1 
ATOM   1608 C C     . LYS A 1 208 ? -53.79240 12.08316  -16.99626 1.000 35.86353 ? 326 LYS B C     1 
ATOM   1609 O O     . LYS A 1 208 ? -54.80672 12.14336  -16.28847 1.000 34.86553 ? 326 LYS B O     1 
ATOM   1610 C CB    . LYS A 1 208 ? -54.19804 11.56209  -19.39069 1.000 42.92568 ? 326 LYS B CB    1 
ATOM   1611 C CG    . LYS A 1 208 ? -53.67088 10.91293  -20.63992 1.000 50.44292 ? 326 LYS B CG    1 
ATOM   1612 C CD    . LYS A 1 208 ? -54.52448 11.35074  -21.82655 1.000 54.47317 ? 326 LYS B CD    1 
ATOM   1613 C CE    . LYS A 1 208 ? -55.15526 12.74108  -21.60913 1.000 56.39839 ? 326 LYS B CE    1 
ATOM   1614 N NZ    . LYS A 1 208 ? -54.26835 13.94527  -21.92797 1.000 53.57362 ? 326 LYS B NZ    1 
ATOM   1615 N N     . PRO A 1 209 ? -52.78951 12.94022  -16.85417 1.000 36.91502 ? 327 PRO B N     1 
ATOM   1616 C CA    . PRO A 1 209 ? -52.89939 14.02833  -15.88104 1.000 36.99264 ? 327 PRO B CA    1 
ATOM   1617 C C     . PRO A 1 209 ? -53.78919 15.12793  -16.43337 1.000 32.65492 ? 327 PRO B C     1 
ATOM   1618 O O     . PRO A 1 209 ? -53.87633 15.31203  -17.65466 1.000 34.38398 ? 327 PRO B O     1 
ATOM   1619 C CB    . PRO A 1 209 ? -51.44208 14.49735  -15.69641 1.000 37.88655 ? 327 PRO B CB    1 
ATOM   1620 C CG    . PRO A 1 209 ? -50.80520 14.18825  -16.97731 1.000 38.75257 ? 327 PRO B CG    1 
ATOM   1621 C CD    . PRO A 1 209 ? -51.48178 12.93455  -17.52622 1.000 39.54347 ? 327 PRO B CD    1 
ATOM   1622 N N     . PRO A 1 210 ? -54.46077 15.88357  -15.55596 1.000 32.69355 ? 328 PRO B N     1 
ATOM   1623 C CA    . PRO A 1 210 ? -55.56406 16.74717  -16.01482 1.000 32.56437 ? 328 PRO B CA    1 
ATOM   1624 C C     . PRO A 1 210 ? -55.13514 17.95462  -16.82364 1.000 35.73143 ? 328 PRO B C     1 
ATOM   1625 O O     . PRO A 1 210 ? -55.95338 18.46029  -17.59719 1.000 36.58690 ? 328 PRO B O     1 
ATOM   1626 C CB    . PRO A 1 210 ? -56.24318 17.19534  -14.70981 1.000 35.20867 ? 328 PRO B CB    1 
ATOM   1627 C CG    . PRO A 1 210 ? -55.24727 16.91172  -13.59330 1.000 34.55219 ? 328 PRO B CG    1 
ATOM   1628 C CD    . PRO A 1 210 ? -54.33891 15.80356  -14.08944 1.000 32.81419 ? 328 PRO B CD    1 
ATOM   1629 N N     . PHE A 1 211 ? -53.91344 18.47103  -16.64014 1.000 34.94665 ? 329 PHE B N     1 
ATOM   1630 C CA    . PHE A 1 211 ? -53.48011 19.70183  -17.30242 1.000 34.40818 ? 329 PHE B CA    1 
ATOM   1631 C C     . PHE A 1 211 ? -52.47068 19.43621  -18.41142 1.000 39.13052 ? 329 PHE B C     1 
ATOM   1632 O O     . PHE A 1 211 ? -51.78936 20.35922  -18.86669 1.000 39.13520 ? 329 PHE B O     1 
ATOM   1633 C CB    . PHE A 1 211 ? -52.91268 20.66642  -16.26365 1.000 33.61876 ? 329 PHE B CB    1 
ATOM   1634 C CG    . PHE A 1 211 ? -53.84525 20.89070  -15.11451 1.000 34.05598 ? 329 PHE B CG    1 
ATOM   1635 C CD1   . PHE A 1 211 ? -55.02144 21.60003  -15.30967 1.000 34.38649 ? 329 PHE B CD1   1 
ATOM   1636 C CD2   . PHE A 1 211 ? -53.59376 20.33488  -13.87143 1.000 33.57419 ? 329 PHE B CD2   1 
ATOM   1637 C CE1   . PHE A 1 211 ? -55.89635 21.82111  -14.27671 1.000 33.11376 ? 329 PHE B CE1   1 
ATOM   1638 C CE2   . PHE A 1 211 ? -54.51320 20.51040  -12.81454 1.000 34.09979 ? 329 PHE B CE2   1 
ATOM   1639 C CZ    . PHE A 1 211 ? -55.67228 21.27000  -13.03585 1.000 32.20977 ? 329 PHE B CZ    1 
ATOM   1640 N N     . GLU A 1 212 ? -52.38002 18.18258  -18.85196 1.000 41.71473 ? 330 GLU B N     1 
ATOM   1641 C CA    . GLU A 1 212 ? -51.47537 17.80388  -19.92589 1.000 46.80882 ? 330 GLU B CA    1 
ATOM   1642 C C     . GLU A 1 212 ? -51.72822 18.64337  -21.17309 1.000 43.87932 ? 330 GLU B C     1 
ATOM   1643 O O     . GLU A 1 212 ? -52.87737 18.86909  -21.56543 1.000 39.82846 ? 330 GLU B O     1 
ATOM   1644 C CB    . GLU A 1 212 ? -51.66027 16.31513  -20.23247 1.000 44.40783 ? 330 GLU B CB    1 
ATOM   1645 C CG    . GLU A 1 212 ? -50.61660 15.75772  -21.13724 1.000 51.59226 ? 330 GLU B CG    1 
ATOM   1646 C CD    . GLU A 1 212 ? -50.58234 14.26252  -21.06638 1.000 50.15847 ? 330 GLU B CD    1 
ATOM   1647 O OE1   . GLU A 1 212 ? -51.51616 13.63601  -21.59544 1.000 46.18724 ? 330 GLU B OE1   1 
ATOM   1648 O OE2   . GLU A 1 212 ? -49.62146 13.72693  -20.47572 1.000 52.65797 ? 330 GLU B OE2   1 
ATOM   1649 N N     . ALA A 1 213 ? -50.64087 19.14056  -21.76712 1.000 41.02962 ? 331 ALA B N     1 
ATOM   1650 C CA    . ALA A 1 213 ? -50.68664 19.96307  -22.96684 1.000 44.89139 ? 331 ALA B CA    1 
ATOM   1651 C C     . ALA A 1 213 ? -49.45084 19.67113  -23.81203 1.000 47.04912 ? 331 ALA B C     1 
ATOM   1652 O O     . ALA A 1 213 ? -48.51690 18.99554  -23.36940 1.000 48.29412 ? 331 ALA B O     1 
ATOM   1653 C CB    . ALA A 1 213 ? -50.76760 21.45417  -22.62643 1.000 44.82088 ? 331 ALA B CB    1 
ATOM   1654 N N     . ASN A 1 214 ? -49.43073 20.22795  -25.02948 1.000 44.89045 ? 332 ASN B N     1 
ATOM   1655 C CA    . ASN A 1 214 ? -48.37853 19.86741  -25.97477 1.000 48.88164 ? 332 ASN B CA    1 
ATOM   1656 C C     . ASN A 1 214 ? -47.05755 20.53826  -25.62724 1.000 49.62551 ? 332 ASN B C     1 
ATOM   1657 O O     . ASN A 1 214 ? -45.98566 19.99071  -25.91771 1.000 47.48342 ? 332 ASN B O     1 
ATOM   1658 C CB    . ASN A 1 214 ? -48.77971 20.26996  -27.38343 1.000 49.41473 ? 332 ASN B CB    1 
ATOM   1659 C CG    . ASN A 1 214 ? -49.62178 19.22703  -28.05974 1.000 53.61101 ? 332 ASN B CG    1 
ATOM   1660 O OD1   . ASN A 1 214 ? -49.80631 18.11669  -27.54859 1.000 54.44158 ? 332 ASN B OD1   1 
ATOM   1661 N ND2   . ASN A 1 214 ? -50.15773 19.58000  -29.21807 1.000 58.17548 ? 332 ASN B ND2   1 
ATOM   1662 N N     . THR A 1 215 ? -47.11690 21.72644  -25.04118 1.000 46.71761 ? 333 THR B N     1 
ATOM   1663 C CA    . THR A 1 215 ? -45.94245 22.47656  -24.63356 1.000 44.82517 ? 333 THR B CA    1 
ATOM   1664 C C     . THR A 1 215 ? -45.97728 22.71623  -23.13039 1.000 46.10788 ? 333 THR B C     1 
ATOM   1665 O O     . THR A 1 215 ? -47.03650 22.67050  -22.49847 1.000 45.82822 ? 333 THR B O     1 
ATOM   1666 C CB    . THR A 1 215 ? -45.86151 23.82050  -25.37143 1.000 47.92790 ? 333 THR B CB    1 
ATOM   1667 O OG1   . THR A 1 215 ? -46.84422 24.71631  -24.83851 1.000 44.88562 ? 333 THR B OG1   1 
ATOM   1668 C CG2   . THR A 1 215 ? -46.09659 23.64414  -26.86778 1.000 51.03784 ? 333 THR B CG2   1 
ATOM   1669 N N     . TYR A 1 216 ? -44.79626 22.97698  -22.56660 1.000 41.85217 ? 334 TYR B N     1 
ATOM   1670 C CA    . TYR A 1 216 ? -44.69824 23.34810  -21.15900 1.000 44.84310 ? 334 TYR B CA    1 
ATOM   1671 C C     . TYR A 1 216 ? -45.42276 24.66538  -20.89063 1.000 44.85560 ? 334 TYR B C     1 
ATOM   1672 O O     . TYR A 1 216 ? -46.09641 24.82394  -19.85941 1.000 42.47452 ? 334 TYR B O     1 
ATOM   1673 C CB    . TYR A 1 216 ? -43.22352 23.46421  -20.75559 1.000 44.33801 ? 334 TYR B CB    1 
ATOM   1674 C CG    . TYR A 1 216 ? -42.53020 22.13578  -20.50705 1.000 46.79728 ? 334 TYR B CG    1 
ATOM   1675 C CD1   . TYR A 1 216 ? -43.18815 20.93168  -20.73071 1.000 47.14019 ? 334 TYR B CD1   1 
ATOM   1676 C CD2   . TYR A 1 216 ? -41.20144 22.08518  -20.08049 1.000 45.86629 ? 334 TYR B CD2   1 
ATOM   1677 C CE1   . TYR A 1 216 ? -42.54701 19.70673  -20.52171 1.000 44.40981 ? 334 TYR B CE1   1 
ATOM   1678 C CE2   . TYR A 1 216 ? -40.55858 20.86151  -19.86300 1.000 44.12487 ? 334 TYR B CE2   1 
ATOM   1679 C CZ    . TYR A 1 216 ? -41.23831 19.68387  -20.09564 1.000 45.57065 ? 334 TYR B CZ    1 
ATOM   1680 O OH    . TYR A 1 216 ? -40.60630 18.47565  -19.88561 1.000 46.88213 ? 334 TYR B OH    1 
ATOM   1681 N N     . GLN A 1 217 ? -45.28802 25.62367  -21.80956 1.000 41.73590 ? 335 GLN B N     1 
ATOM   1682 C CA    A GLN A 1 217 ? -45.92590 26.92473  -21.63033 0.000 43.77758 ? 335 GLN B CA    1 
ATOM   1683 C CA    B GLN A 1 217 ? -45.92535 26.92384  -21.61064 1.000 43.82696 ? 335 GLN B CA    1 
ATOM   1684 C C     . GLN A 1 217 ? -47.44251 26.79534  -21.58380 1.000 43.33126 ? 335 GLN B C     1 
ATOM   1685 O O     . GLN A 1 217 ? -48.11110 27.49509  -20.81389 1.000 45.02616 ? 335 GLN B O     1 
ATOM   1686 C CB    A GLN A 1 217 ? -45.50608 27.87242  -22.75397 0.000 44.82545 ? 335 GLN B CB    1 
ATOM   1687 C CB    B GLN A 1 217 ? -45.50490 27.90794  -22.70422 1.000 44.29979 ? 335 GLN B CB    1 
ATOM   1688 N N     . GLU A 1 218 ? -48.00632 25.90448  -22.41047 1.000 42.65714 ? 336 GLU B N     1 
ATOM   1689 C CA    . GLU A 1 218 ? -49.45086 25.69898  -22.37108 1.000 45.20098 ? 336 GLU B CA    1 
ATOM   1690 C C     . GLU A 1 218 ? -49.85817 25.01990  -21.08063 1.000 45.51568 ? 336 GLU B C     1 
ATOM   1691 O O     . GLU A 1 218 ? -50.90382 25.35023  -20.51049 1.000 43.06975 ? 336 GLU B O     1 
ATOM   1692 C CB    . GLU A 1 218 ? -49.94873 24.86355  -23.54552 1.000 44.88323 ? 336 GLU B CB    1 
ATOM   1693 C CG    . GLU A 1 218 ? -50.00681 25.56267  -24.88884 1.000 53.78656 ? 336 GLU B CG    1 
ATOM   1694 C CD    . GLU A 1 218 ? -50.30210 24.56937  -26.01075 1.000 57.24184 ? 336 GLU B CD    1 
ATOM   1695 O OE1   . GLU A 1 218 ? -49.42231 23.73996  -26.33991 1.000 59.59549 ? 336 GLU B OE1   1 
ATOM   1696 O OE2   . GLU A 1 218 ? -51.44740 24.59548  -26.52364 1.000 63.73259 ? 336 GLU B OE2   1 
ATOM   1697 N N     . THR A 1 219 ? -49.05030 24.05228  -20.62120 1.000 40.28934 ? 337 THR B N     1 
ATOM   1698 C CA    . THR A 1 219 ? -49.31443 23.39884  -19.34418 1.000 38.48285 ? 337 THR B CA    1 
ATOM   1699 C C     . THR A 1 219 ? -49.36277 24.41213  -18.20264 1.000 41.27741 ? 337 THR B C     1 
ATOM   1700 O O     . THR A 1 219 ? -50.25430 24.34892  -17.34547 1.000 39.90256 ? 337 THR B O     1 
ATOM   1701 C CB    . THR A 1 219 ? -48.24972 22.33313  -19.08923 1.000 42.90552 ? 337 THR B CB    1 
ATOM   1702 O OG1   . THR A 1 219 ? -48.28276 21.38450  -20.15808 1.000 44.81472 ? 337 THR B OG1   1 
ATOM   1703 C CG2   . THR A 1 219 ? -48.51467 21.60018  -17.78162 1.000 41.99012 ? 337 THR B CG2   1 
ATOM   1704 N N     . TYR A 1 220 ? -48.42490 25.36951  -18.19073 1.000 38.88610 ? 338 TYR B N     1 
ATOM   1705 C CA    . TYR A 1 220 ? -48.41746 26.42592  -17.18298 1.000 38.35496 ? 338 TYR B CA    1 
ATOM   1706 C C     . TYR A 1 220 ? -49.74463 27.16369  -17.16381 1.000 39.76862 ? 338 TYR B C     1 
ATOM   1707 O O     . TYR A 1 220 ? -50.31579 27.41890  -16.09495 1.000 38.13333 ? 338 TYR B O     1 
ATOM   1708 C CB    . TYR A 1 220 ? -47.30508 27.44241  -17.46226 1.000 39.12257 ? 338 TYR B CB    1 
ATOM   1709 C CG    . TYR A 1 220 ? -45.91890 26.89175  -17.40083 1.000 47.02141 ? 338 TYR B CG    1 
ATOM   1710 C CD1   . TYR A 1 220 ? -45.59462 25.86260  -16.53717 1.000 48.14068 ? 338 TYR B CD1   1 
ATOM   1711 C CD2   . TYR A 1 220 ? -44.91880 27.41315  -18.21021 1.000 49.55431 ? 338 TYR B CD2   1 
ATOM   1712 C CE1   . TYR A 1 220 ? -44.29536 25.37312  -16.48016 1.000 55.27793 ? 338 TYR B CE1   1 
ATOM   1713 C CE2   . TYR A 1 220 ? -43.62218 26.92241  -18.15792 1.000 51.93109 ? 338 TYR B CE2   1 
ATOM   1714 C CZ    . TYR A 1 220 ? -43.32213 25.90604  -17.29759 1.000 56.25582 ? 338 TYR B CZ    1 
ATOM   1715 O OH    . TYR A 1 220 ? -42.04517 25.39893  -17.24521 1.000 65.83244 ? 338 TYR B OH    1 
ATOM   1716 N N     . LYS A 1 221 ? -50.22394 27.55855  -18.34557 1.000 35.83171 ? 339 LYS B N     1 
ATOM   1717 C CA    . LYS A 1 221 ? -51.49210 28.26989  -18.40891 1.000 38.91820 ? 339 LYS B CA    1 
ATOM   1718 C C     . LYS A 1 221 ? -52.63901 27.38816  -17.92976 1.000 38.50414 ? 339 LYS B C     1 
ATOM   1719 O O     . LYS A 1 221 ? -53.51173 27.85568  -17.18779 1.000 37.03994 ? 339 LYS B O     1 
ATOM   1720 C CB    . LYS A 1 221 ? -51.76201 28.78278  -19.82249 1.000 40.94539 ? 339 LYS B CB    1 
ATOM   1721 C CG    . LYS A 1 221 ? -50.59866 29.48313  -20.50950 1.000 49.04574 ? 339 LYS B CG    1 
ATOM   1722 C CD    . LYS A 1 221 ? -51.08115 30.22474  -21.75381 1.000 50.75805 ? 339 LYS B CD    1 
ATOM   1723 C CE    . LYS A 1 221 ? -49.93890 30.97272  -22.43864 1.000 58.12238 ? 339 LYS B CE    1 
ATOM   1724 N NZ    . LYS A 1 221 ? -50.38798 31.67641  -23.67091 1.000 64.85789 ? 339 LYS B NZ    1 
ATOM   1725 N N     . ARG A 1 222 ? -52.65252 26.10381  -18.33152 1.000 34.89960 ? 340 ARG B N     1 
ATOM   1726 C CA    . ARG A 1 222 ? -53.76258 25.24016  -17.92853 1.000 35.15145 ? 340 ARG B CA    1 
ATOM   1727 C C     . ARG A 1 222 ? -53.78512 25.05359  -16.42209 1.000 35.99975 ? 340 ARG B C     1 
ATOM   1728 O O     . ARG A 1 222 ? -54.86299 25.01817  -15.81696 1.000 34.40634 ? 340 ARG B O     1 
ATOM   1729 C CB    . ARG A 1 222 ? -53.69262 23.87232  -18.61492 1.000 39.72632 ? 340 ARG B CB    1 
ATOM   1730 C CG    . ARG A 1 222 ? -53.55589 23.91466  -20.14154 1.000 45.41551 ? 340 ARG B CG    1 
ATOM   1731 C CD    . ARG A 1 222 ? -54.86338 23.74812  -20.87897 1.000 52.03492 ? 340 ARG B CD    1 
ATOM   1732 N NE    . ARG A 1 222 ? -54.64341 23.68864  -22.32428 1.000 54.10797 ? 340 ARG B NE    1 
ATOM   1733 C CZ    . ARG A 1 222 ? -54.51257 22.56915  -23.02429 1.000 55.11420 ? 340 ARG B CZ    1 
ATOM   1734 N NH1   . ARG A 1 222 ? -54.60865 21.37556  -22.45237 1.000 56.56362 ? 340 ARG B NH1   1 
ATOM   1735 N NH2   . ARG A 1 222 ? -54.29218 22.64568  -24.33341 1.000 60.89634 ? 340 ARG B NH2   1 
ATOM   1736 N N     . ILE A 1 223 ? -52.61055 24.90992  -15.79710 1.000 32.51955 ? 341 ILE B N     1 
ATOM   1737 C CA    . ILE A 1 223 ? -52.56328 24.78467  -14.34134 1.000 33.57738 ? 341 ILE B CA    1 
ATOM   1738 C C     . ILE A 1 223 ? -53.03279 26.06929  -13.68301 1.000 36.01928 ? 341 ILE B C     1 
ATOM   1739 O O     . ILE A 1 223 ? -53.85583 26.05185  -12.75541 1.000 36.66326 ? 341 ILE B O     1 
ATOM   1740 C CB    . ILE A 1 223 ? -51.14755 24.43041  -13.86885 1.000 34.68324 ? 341 ILE B CB    1 
ATOM   1741 C CG1   . ILE A 1 223 ? -50.76610 23.01690  -14.34632 1.000 31.27841 ? 341 ILE B CG1   1 
ATOM   1742 C CG2   . ILE A 1 223 ? -51.06230 24.61563  -12.34082 1.000 35.88105 ? 341 ILE B CG2   1 
ATOM   1743 C CD1   . ILE A 1 223 ? -49.24725 22.70324  -14.16469 1.000 33.67743 ? 341 ILE B CD1   1 
ATOM   1744 N N     . SER A 1 224 ? -52.49179 27.20118  -14.14056 1.000 35.83363 ? 342 SER B N     1 
ATOM   1745 C CA    . SER A 1 224 ? -52.77206 28.47487  -13.49998 1.000 36.80569 ? 342 SER B CA    1 
ATOM   1746 C C     . SER A 1 224 ? -54.24779 28.83191  -13.59240 1.000 38.93640 ? 342 SER B C     1 
ATOM   1747 O O     . SER A 1 224 ? -54.79927 29.42391  -12.65920 1.000 36.42328 ? 342 SER B O     1 
ATOM   1748 C CB    . SER A 1 224 ? -51.90772 29.56708  -14.13158 1.000 40.91828 ? 342 SER B CB    1 
ATOM   1749 O OG    . SER A 1 224 ? -52.23243 30.83162  -13.58210 1.000 44.92291 ? 342 SER B OG    1 
ATOM   1750 N N     . ARG A 1 225 ? -54.90172 28.47499  -14.69311 1.000 35.65204 ? 343 ARG B N     1 
ATOM   1751 C CA    . ARG A 1 225 ? -56.31476 28.75952  -14.91473 1.000 37.43912 ? 343 ARG B CA    1 
ATOM   1752 C C     . ARG A 1 225 ? -57.21262 27.59910  -14.50459 1.000 40.41371 ? 343 ARG B C     1 
ATOM   1753 O O     . ARG A 1 225 ? -58.43257 27.68791  -14.68520 1.000 39.85900 ? 343 ARG B O     1 
ATOM   1754 C CB    . ARG A 1 225 ? -56.54256 29.11692  -16.38650 1.000 40.89225 ? 343 ARG B CB    1 
ATOM   1755 C CG    . ARG A 1 225 ? -55.62470 30.23377  -16.87186 1.000 43.39905 ? 343 ARG B CG    1 
ATOM   1756 C CD    . ARG A 1 225 ? -55.68399 30.43868  -18.38415 1.000 42.83642 ? 343 ARG B CD    1 
ATOM   1757 N NE    . ARG A 1 225 ? -54.76443 31.50924  -18.75867 1.000 51.00928 ? 343 ARG B NE    1 
ATOM   1758 C CZ    . ARG A 1 225 ? -54.32502 31.73217  -19.98891 1.000 46.08155 ? 343 ARG B CZ    1 
ATOM   1759 N NH1   . ARG A 1 225 ? -54.73649 31.00257  -21.01115 1.000 50.63098 ? 343 ARG B NH1   1 
ATOM   1760 N NH2   . ARG A 1 225 ? -53.46112 32.72314  -20.19895 1.000 51.74621 ? 343 ARG B NH2   1 
ATOM   1761 N N     . VAL A 1 226 ? -56.62742 26.54085  -13.93356 1.000 34.04470 ? 344 VAL B N     1 
ATOM   1762 C CA    . VAL A 1 226 ? -57.30055 25.30262  -13.53833 1.000 34.35467 ? 344 VAL B CA    1 
ATOM   1763 C C     . VAL A 1 226 ? -58.24901 24.84987  -14.64233 1.000 37.58363 ? 344 VAL B C     1 
ATOM   1764 O O     . VAL A 1 226 ? -59.45708 24.68901  -14.43539 1.000 39.22873 ? 344 VAL B O     1 
ATOM   1765 C CB    . VAL A 1 226 ? -57.99275 25.46382  -12.17257 1.000 38.06261 ? 344 VAL B CB    1 
ATOM   1766 C CG1   . VAL A 1 226 ? -58.42405 24.11478  -11.63867 1.000 44.03932 ? 344 VAL B CG1   1 
ATOM   1767 C CG2   . VAL A 1 226 ? -57.00485 26.04282  -11.18310 1.000 38.93510 ? 344 VAL B CG2   1 
ATOM   1768 N N     . GLU A 1 227 ? -57.69821 24.63836  -15.83518 1.000 35.98038 ? 345 GLU B N     1 
ATOM   1769 C CA    . GLU A 1 227 ? -58.47841 24.22750  -16.99619 1.000 34.97918 ? 345 GLU B CA    1 
ATOM   1770 C C     . GLU A 1 227 ? -58.38066 22.71417  -17.10721 1.000 40.05898 ? 345 GLU B C     1 
ATOM   1771 O O     . GLU A 1 227 ? -57.42932 22.17909  -17.67256 1.000 39.00979 ? 345 GLU B O     1 
ATOM   1772 C CB    . GLU A 1 227 ? -57.99919 24.90463  -18.27372 1.000 37.09493 ? 345 GLU B CB    1 
ATOM   1773 C CG    . GLU A 1 227 ? -57.98197 26.41840  -18.17898 1.000 43.12104 ? 345 GLU B CG    1 
ATOM   1774 C CD    . GLU A 1 227 ? -57.48573 27.09350  -19.44937 1.000 43.70862 ? 345 GLU B CD    1 
ATOM   1775 O OE1   . GLU A 1 227 ? -56.89169 26.39764  -20.30172 1.000 49.43254 ? 345 GLU B OE1   1 
ATOM   1776 O OE2   . GLU A 1 227 ? -57.68100 28.32794  -19.57838 1.000 46.57784 ? 345 GLU B OE2   1 
ATOM   1777 N N     . PHE A 1 228 ? -59.35913 22.02550  -16.53025 1.000 36.11266 ? 346 PHE B N     1 
ATOM   1778 C CA    . PHE A 1 228 ? -59.48235 20.58221  -16.68567 1.000 39.81223 ? 346 PHE B CA    1 
ATOM   1779 C C     . PHE A 1 228 ? -60.95222 20.24224  -16.88302 1.000 42.98595 ? 346 PHE B C     1 
ATOM   1780 O O     . PHE A 1 228 ? -61.84066 21.00018  -16.47071 1.000 39.23018 ? 346 PHE B O     1 
ATOM   1781 C CB    . PHE A 1 228 ? -58.90932 19.80173  -15.48327 1.000 38.46073 ? 346 PHE B CB    1 
ATOM   1782 C CG    . PHE A 1 228 ? -59.69359 19.95633  -14.22113 1.000 43.66812 ? 346 PHE B CG    1 
ATOM   1783 C CD1   . PHE A 1 228 ? -59.56495 21.08683  -13.43930 1.000 38.33475 ? 346 PHE B CD1   1 
ATOM   1784 C CD2   . PHE A 1 228 ? -60.54330 18.95212  -13.79751 1.000 46.16257 ? 346 PHE B CD2   1 
ATOM   1785 C CE1   . PHE A 1 228 ? -60.26614 21.23315  -12.27818 1.000 44.00605 ? 346 PHE B CE1   1 
ATOM   1786 C CE2   . PHE A 1 228 ? -61.27029 19.09692  -12.62286 1.000 49.98552 ? 346 PHE B CE2   1 
ATOM   1787 C CZ    . PHE A 1 228 ? -61.13201 20.23629  -11.86415 1.000 49.25929 ? 346 PHE B CZ    1 
ATOM   1788 N N     . THR A 1 229 ? -61.19905 19.11107  -17.55068 1.000 39.88360 ? 347 THR B N     1 
ATOM   1789 C CA    . THR A 1 229 ? -62.54830 18.59576  -17.76446 1.000 37.50583 ? 347 THR B CA    1 
ATOM   1790 C C     . THR A 1 229 ? -62.51629 17.09430  -17.49254 1.000 39.61959 ? 347 THR B C     1 
ATOM   1791 O O     . THR A 1 229 ? -61.45573 16.46855  -17.51814 1.000 34.47524 ? 347 THR B O     1 
ATOM   1792 C CB    . THR A 1 229 ? -63.06203 18.88907  -19.19614 1.000 36.95919 ? 347 THR B CB    1 
ATOM   1793 O OG1   . THR A 1 229 ? -62.18913 18.29007  -20.17389 1.000 39.35049 ? 347 THR B OG1   1 
ATOM   1794 C CG2   . THR A 1 229 ? -63.11820 20.40516  -19.47641 1.000 36.77362 ? 347 THR B CG2   1 
ATOM   1795 N N     . PHE A 1 230 ? -63.70761 16.51405  -17.21263 1.000 37.20233 ? 348 PHE B N     1 
ATOM   1796 C CA    . PHE A 1 230 ? -63.80429 15.08852  -16.85678 1.000 39.53657 ? 348 PHE B CA    1 
ATOM   1797 C C     . PHE A 1 230 ? -64.33405 14.27010  -18.02422 1.000 42.73702 ? 348 PHE B C     1 
ATOM   1798 O O     . PHE A 1 230 ? -65.33458 14.67640  -18.63665 1.000 40.16592 ? 348 PHE B O     1 
ATOM   1799 C CB    . PHE A 1 230 ? -64.74216 14.90670  -15.66684 1.000 42.39902 ? 348 PHE B CB    1 
ATOM   1800 C CG    . PHE A 1 230 ? -64.25922 15.52125  -14.38503 1.000 41.71039 ? 348 PHE B CG    1 
ATOM   1801 C CD1   . PHE A 1 230 ? -63.29004 14.88670  -13.62594 1.000 38.29982 ? 348 PHE B CD1   1 
ATOM   1802 C CD2   . PHE A 1 230 ? -64.83640 16.68445  -13.89932 1.000 39.85153 ? 348 PHE B CD2   1 
ATOM   1803 C CE1   . PHE A 1 230 ? -62.86787 15.41765  -12.42039 1.000 38.26235 ? 348 PHE B CE1   1 
ATOM   1804 C CE2   . PHE A 1 230 ? -64.42120 17.22073  -12.69901 1.000 42.74907 ? 348 PHE B CE2   1 
ATOM   1805 C CZ    . PHE A 1 230 ? -63.43307 16.59232  -11.95571 1.000 41.68621 ? 348 PHE B CZ    1 
ATOM   1806 N N     . PRO A 1 231 ? -63.74251 13.11273  -18.34312 1.000 38.97098 ? 349 PRO B N     1 
ATOM   1807 C CA    . PRO A 1 231 ? -64.43322 12.15716  -19.22089 1.000 40.13971 ? 349 PRO B CA    1 
ATOM   1808 C C     . PRO A 1 231 ? -65.75955 11.71311  -18.62204 1.000 40.11383 ? 349 PRO B C     1 
ATOM   1809 O O     . PRO A 1 231 ? -65.99183 11.78948  -17.41312 1.000 41.18665 ? 349 PRO B O     1 
ATOM   1810 C CB    . PRO A 1 231 ? -63.45868 10.97375  -19.32190 1.000 40.47477 ? 349 PRO B CB    1 
ATOM   1811 C CG    . PRO A 1 231 ? -62.15099 11.47235  -18.83165 1.000 42.16539 ? 349 PRO B CG    1 
ATOM   1812 C CD    . PRO A 1 231 ? -62.41402 12.63730  -17.92490 1.000 39.09998 ? 349 PRO B CD    1 
ATOM   1813 N N     . ASP A 1 232 ? -66.62885 11.20665  -19.50111 1.000 45.61345 ? 350 ASP B N     1 
ATOM   1814 C CA    . ASP A 1 232 ? -67.98935 10.83511  -19.10678 1.000 46.14947 ? 350 ASP B CA    1 
ATOM   1815 C C     . ASP A 1 232 ? -68.01996 9.82177   -17.96151 1.000 45.06642 ? 350 ASP B C     1 
ATOM   1816 O O     . ASP A 1 232 ? -68.93061 9.86992   -17.12401 1.000 44.59087 ? 350 ASP B O     1 
ATOM   1817 C CB    . ASP A 1 232 ? -68.74083 10.27481  -20.31619 1.000 50.77897 ? 350 ASP B CB    1 
ATOM   1818 C CG    . ASP A 1 232 ? -69.23531 11.36394  -21.26668 1.000 57.57909 ? 350 ASP B CG    1 
ATOM   1819 O OD1   . ASP A 1 232 ? -69.20476 12.55743  -20.88800 1.000 59.53722 ? 350 ASP B OD1   1 
ATOM   1820 O OD2   . ASP A 1 232 ? -69.65243 11.01594  -22.40286 1.000 63.87376 ? 350 ASP B OD2   1 
ATOM   1821 N N     . PHE A 1 233 ? -67.05010 8.90025   -17.90018 1.000 44.23751 ? 351 PHE B N     1 
ATOM   1822 C CA    . PHE A 1 233 ? -67.10898 7.79463   -16.94076 1.000 44.41652 ? 351 PHE B CA    1 
ATOM   1823 C C     . PHE A 1 233 ? -66.70609 8.17801   -15.51945 1.000 45.15009 ? 351 PHE B C     1 
ATOM   1824 O O     . PHE A 1 233 ? -66.89396 7.37183   -14.60080 1.000 46.30829 ? 351 PHE B O     1 
ATOM   1825 C CB    . PHE A 1 233 ? -66.24364 6.61100   -17.42082 1.000 44.44858 ? 351 PHE B CB    1 
ATOM   1826 C CG    . PHE A 1 233 ? -64.78622 6.93810   -17.61708 1.000 46.31956 ? 351 PHE B CG    1 
ATOM   1827 C CD1   . PHE A 1 233 ? -63.89405 6.93426   -16.54426 1.000 43.45802 ? 351 PHE B CD1   1 
ATOM   1828 C CD2   . PHE A 1 233 ? -64.30021 7.22850   -18.88454 1.000 41.73010 ? 351 PHE B CD2   1 
ATOM   1829 C CE1   . PHE A 1 233 ? -62.54644 7.22767   -16.74222 1.000 41.08672 ? 351 PHE B CE1   1 
ATOM   1830 C CE2   . PHE A 1 233 ? -62.95453 7.53358   -19.08224 1.000 46.38170 ? 351 PHE B CE2   1 
ATOM   1831 C CZ    . PHE A 1 233 ? -62.08407 7.53942   -17.99752 1.000 40.87825 ? 351 PHE B CZ    1 
ATOM   1832 N N     . VAL A 1 234 ? -66.14887 9.36439   -15.29359 1.000 41.45760 ? 352 VAL B N     1 
ATOM   1833 C CA    . VAL A 1 234 ? -65.81088 9.75057   -13.92734 1.000 42.54517 ? 352 VAL B CA    1 
ATOM   1834 C C     . VAL A 1 234 ? -67.09952 9.97147   -13.14529 1.000 40.28052 ? 352 VAL B C     1 
ATOM   1835 O O     . VAL A 1 234 ? -67.94842 10.77420  -13.54583 1.000 43.30441 ? 352 VAL B O     1 
ATOM   1836 C CB    . VAL A 1 234 ? -64.92376 11.00256  -13.91373 1.000 42.61485 ? 352 VAL B CB    1 
ATOM   1837 C CG1   . VAL A 1 234 ? -64.54258 11.34356  -12.49751 1.000 41.42921 ? 352 VAL B CG1   1 
ATOM   1838 C CG2   . VAL A 1 234 ? -63.68387 10.75031  -14.76028 1.000 40.55379 ? 352 VAL B CG2   1 
ATOM   1839 N N     . THR A 1 235 ? -67.24440 9.27358   -12.02095 1.000 41.20446 ? 353 THR B N     1 
ATOM   1840 C CA    . THR A 1 235 ? -68.49323 9.34141   -11.26695 1.000 45.55237 ? 353 THR B CA    1 
ATOM   1841 C C     . THR A 1 235 ? -68.61977 10.65703  -10.50594 1.000 47.67835 ? 353 THR B C     1 
ATOM   1842 O O     . THR A 1 235 ? -67.65189 11.39701  -10.29344 1.000 43.01966 ? 353 THR B O     1 
ATOM   1843 C CB    . THR A 1 235 ? -68.61541 8.18205   -10.28201 1.000 45.51214 ? 353 THR B CB    1 
ATOM   1844 O OG1   . THR A 1 235 ? -67.63492 8.32272   -9.24277  1.000 44.32904 ? 353 THR B OG1   1 
ATOM   1845 C CG2   . THR A 1 235 ? -68.46301 6.83621   -10.99619 1.000 45.90377 ? 353 THR B CG2   1 
ATOM   1846 N N     . GLU A 1 236 ? -69.84971 10.95288  -10.08555 1.000 46.41959 ? 354 GLU B N     1 
ATOM   1847 C CA    . GLU A 1 236 ? -70.08126 12.26301  -9.49609  1.000 47.17583 ? 354 GLU B CA    1 
ATOM   1848 C C     . GLU A 1 236 ? -69.35027 12.40294  -8.16300  1.000 45.91788 ? 354 GLU B C     1 
ATOM   1849 O O     . GLU A 1 236 ? -68.90561 13.50202  -7.81322  1.000 42.90416 ? 354 GLU B O     1 
ATOM   1850 C CB    . GLU A 1 236 ? -71.59373 12.51902  -9.37177  1.000 53.26946 ? 354 GLU B CB    1 
ATOM   1851 C CG    . GLU A 1 236 ? -72.03200 13.23016  -8.11046  1.000 58.49831 ? 354 GLU B CG    1 
ATOM   1852 C CD    . GLU A 1 236 ? -73.54862 13.22890  -7.92601  1.000 70.31447 ? 354 GLU B CD    1 
ATOM   1853 O OE1   . GLU A 1 236 ? -74.28556 13.11360  -8.93756  1.000 75.25292 ? 354 GLU B OE1   1 
ATOM   1854 O OE2   . GLU A 1 236 ? -73.99886 13.35410  -6.76562  1.000 76.59463 ? 354 GLU B OE2   1 
ATOM   1855 N N     . GLY A 1 237 ? -69.16373 11.30310  -7.43289  1.000 42.68374 ? 355 GLY B N     1 
ATOM   1856 C CA    . GLY A 1 237 ? -68.40545 11.38232  -6.19292  1.000 45.07532 ? 355 GLY B CA    1 
ATOM   1857 C C     . GLY A 1 237 ? -66.93152 11.66892  -6.43253  1.000 42.27048 ? 355 GLY B C     1 
ATOM   1858 O O     . GLY A 1 237 ? -66.31528 12.44697  -5.69724  1.000 39.68811 ? 355 GLY B O     1 
ATOM   1859 N N     . ALA A 1 238 ? -66.35452 11.04376  -7.46282  1.000 39.29286 ? 356 ALA B N     1 
ATOM   1860 C CA    . ALA A 1 238 ? -64.96573 11.31818  -7.84311  1.000 41.02097 ? 356 ALA B CA    1 
ATOM   1861 C C     . ALA A 1 238 ? -64.79839 12.74687  -8.33450  1.000 40.37817 ? 356 ALA B C     1 
ATOM   1862 O O     . ALA A 1 238 ? -63.82317 13.42550  -7.98444  1.000 40.46891 ? 356 ALA B O     1 
ATOM   1863 C CB    . ALA A 1 238 ? -64.51975 10.33259  -8.91968  1.000 39.25314 ? 356 ALA B CB    1 
ATOM   1864 N N     . ARG A 1 239 ? -65.73731 13.22054  -9.15187  1.000 39.51946 ? 357 ARG B N     1 
ATOM   1865 C CA    . ARG A 1 239 ? -65.71770 14.61378  -9.58834  1.000 41.42527 ? 357 ARG B CA    1 
ATOM   1866 C C     . ARG A 1 239 ? -65.73285 15.57214  -8.40465  1.000 41.53724 ? 357 ARG B C     1 
ATOM   1867 O O     . ARG A 1 239 ? -65.02611 16.58937  -8.40502  1.000 40.84264 ? 357 ARG B O     1 
ATOM   1868 C CB    . ARG A 1 239 ? -66.91714 14.88381  -10.49137 1.000 39.69253 ? 357 ARG B CB    1 
ATOM   1869 C CG    . ARG A 1 239 ? -66.80811 14.25331  -11.84974 1.000 42.13762 ? 357 ARG B CG    1 
ATOM   1870 C CD    . ARG A 1 239 ? -68.05979 14.51446  -12.67369 1.000 44.75285 ? 357 ARG B CD    1 
ATOM   1871 N NE    . ARG A 1 239 ? -68.08566 13.61245  -13.82145 1.000 48.74050 ? 357 ARG B NE    1 
ATOM   1872 C CZ    . ARG A 1 239 ? -68.19109 13.98934  -15.08753 1.000 46.49025 ? 357 ARG B CZ    1 
ATOM   1873 N NH1   . ARG A 1 239 ? -68.34051 15.26458  -15.42463 1.000 47.04519 ? 357 ARG B NH1   1 
ATOM   1874 N NH2   . ARG A 1 239 ? -68.15924 13.06345  -16.04048 1.000 45.95517 ? 357 ARG B NH2   1 
ATOM   1875 N N     . ASP A 1 240 ? -66.54050 15.27094  -7.38619  1.000 41.78007 ? 358 ASP B N     1 
ATOM   1876 C CA    . ASP A 1 240 ? -66.62458 16.15353  -6.22755  1.000 41.83035 ? 358 ASP B CA    1 
ATOM   1877 C C     . ASP A 1 240 ? -65.28500 16.24159  -5.49958  1.000 40.19543 ? 358 ASP B C     1 
ATOM   1878 O O     . ASP A 1 240 ? -64.79738 17.34121  -5.20923  1.000 39.89147 ? 358 ASP B O     1 
ATOM   1879 C CB    . ASP A 1 240 ? -67.71982 15.67904  -5.27831  1.000 43.01698 ? 358 ASP B CB    1 
ATOM   1880 C CG    . ASP A 1 240 ? -67.88762 16.60148  -4.08185  1.000 44.04753 ? 358 ASP B CG    1 
ATOM   1881 O OD1   . ASP A 1 240 ? -68.56197 17.63467  -4.23478  1.000 51.17252 ? 358 ASP B OD1   1 
ATOM   1882 O OD2   . ASP A 1 240 ? -67.32047 16.31904  -3.00756  1.000 44.87685 ? 358 ASP B OD2   1 
ATOM   1883 N N     . LEU A 1 241 ? -64.67452 15.09951  -5.18428  1.000 37.22819 ? 359 LEU B N     1 
ATOM   1884 C CA    . LEU A 1 241 ? -63.38668 15.12924  -4.48292  1.000 39.40617 ? 359 LEU B CA    1 
ATOM   1885 C C     . LEU A 1 241 ? -62.32631 15.83599  -5.31221  1.000 38.34160 ? 359 LEU B C     1 
ATOM   1886 O O     . LEU A 1 241 ? -61.58376 16.68742  -4.80029  1.000 37.07042 ? 359 LEU B O     1 
ATOM   1887 C CB    . LEU A 1 241 ? -62.91778 13.71196  -4.13184  1.000 41.10131 ? 359 LEU B CB    1 
ATOM   1888 C CG    . LEU A 1 241 ? -61.54131 13.59599  -3.44701  1.000 39.61109 ? 359 LEU B CG    1 
ATOM   1889 C CD1   . LEU A 1 241 ? -61.46175 14.35584  -2.11186  1.000 37.88365 ? 359 LEU B CD1   1 
ATOM   1890 C CD2   . LEU A 1 241 ? -61.16790 12.12119  -3.23153  1.000 37.36146 ? 359 LEU B CD2   1 
ATOM   1891 N N     . ILE A 1 242 ? -62.22340 15.48671  -6.59841  1.000 35.73953 ? 360 ILE B N     1 
ATOM   1892 C CA    . ILE A 1 242 ? -61.17418 16.08718  -7.42432  1.000 34.80822 ? 360 ILE B CA    1 
ATOM   1893 C C     . ILE A 1 242 ? -61.38700 17.58881  -7.53550  1.000 36.86513 ? 360 ILE B C     1 
ATOM   1894 O O     . ILE A 1 242 ? -60.42963 18.36820  -7.45794  1.000 35.30404 ? 360 ILE B O     1 
ATOM   1895 C CB    . ILE A 1 242 ? -61.10516 15.40291  -8.80701  1.000 35.27445 ? 360 ILE B CB    1 
ATOM   1896 C CG1   . ILE A 1 242 ? -60.57409 13.97089  -8.65244  1.000 34.16248 ? 360 ILE B CG1   1 
ATOM   1897 C CG2   . ILE A 1 242 ? -60.25694 16.23365  -9.81232  1.000 31.64063 ? 360 ILE B CG2   1 
ATOM   1898 C CD1   . ILE A 1 242 ? -60.81088 13.09154  -9.87024  1.000 37.28050 ? 360 ILE B CD1   1 
ATOM   1899 N N     . SER A 1 243 ? -62.64763 18.02085  -7.66575  1.000 36.16881 ? 361 SER B N     1 
ATOM   1900 C CA    . SER A 1 243 ? -62.92940 19.44985  -7.81629  1.000 39.75726 ? 361 SER B CA    1 
ATOM   1901 C C     . SER A 1 243 ? -62.57039 20.22826  -6.55801  1.000 38.88438 ? 361 SER B C     1 
ATOM   1902 O O     . SER A 1 243 ? -62.10451 21.37223  -6.64506  1.000 39.25351 ? 361 SER B O     1 
ATOM   1903 C CB    . SER A 1 243 ? -64.39990 19.67109  -8.16564  1.000 42.91888 ? 361 SER B CB    1 
ATOM   1904 O OG    . SER A 1 243 ? -64.67077 19.24970  -9.49336  1.000 46.27984 ? 361 SER B OG    1 
ATOM   1905 N N     . ARG A 1 244 ? -62.81814 19.64048  -5.38548  1.000 36.94424 ? 362 ARG B N     1 
ATOM   1906 C CA    . ARG A 1 244 ? -62.44603 20.27796  -4.12598  1.000 38.02702 ? 362 ARG B CA    1 
ATOM   1907 C C     . ARG A 1 244 ? -60.93777 20.38321  -3.97875  1.000 40.10734 ? 362 ARG B C     1 
ATOM   1908 O O     . ARG A 1 244 ? -60.43061 21.38033  -3.46064  1.000 39.18523 ? 362 ARG B O     1 
ATOM   1909 C CB    . ARG A 1 244 ? -63.03090 19.50075  -2.95742  1.000 38.03080 ? 362 ARG B CB    1 
ATOM   1910 C CG    . ARG A 1 244 ? -64.55662 19.55075  -2.90567  1.000 47.74449 ? 362 ARG B CG    1 
ATOM   1911 C CD    . ARG A 1 244 ? -65.08645 18.74748  -1.72295  1.000 50.02664 ? 362 ARG B CD    1 
ATOM   1912 N NE    . ARG A 1 244 ? -66.51790 18.49671  -1.85119  1.000 54.62890 ? 362 ARG B NE    1 
ATOM   1913 C CZ    . ARG A 1 244 ? -67.44605 19.26933  -1.30515  1.000 55.89362 ? 362 ARG B CZ    1 
ATOM   1914 N NH1   . ARG A 1 244 ? -67.12049 20.35830  -0.63217  1.000 56.61852 ? 362 ARG B NH1   1 
ATOM   1915 N NH2   . ARG A 1 244 ? -68.73271 18.95166  -1.45373  1.000 58.33806 ? 362 ARG B NH2   1 
ATOM   1916 N N     . LEU A 1 245 ? -60.19680 19.35655  -4.41001  1.000 37.90502 ? 363 LEU B N     1 
ATOM   1917 C CA    . LEU A 1 245 ? -58.74308 19.40335  -4.25301  1.000 32.68688 ? 363 LEU B CA    1 
ATOM   1918 C C     . LEU A 1 245 ? -58.08715 20.34063  -5.25709  1.000 35.25648 ? 363 LEU B C     1 
ATOM   1919 O O     . LEU A 1 245 ? -57.03936 20.93112  -4.95564  1.000 35.93087 ? 363 LEU B O     1 
ATOM   1920 C CB    . LEU A 1 245 ? -58.13062 18.00313  -4.40299  1.000 32.24842 ? 363 LEU B CB    1 
ATOM   1921 C CG    . LEU A 1 245 ? -58.45933 16.98584  -3.30857  1.000 33.34641 ? 363 LEU B CG    1 
ATOM   1922 C CD1   . LEU A 1 245 ? -58.10358 15.55876  -3.77945  1.000 34.54839 ? 363 LEU B CD1   1 
ATOM   1923 C CD2   . LEU A 1 245 ? -57.75313 17.31908  -1.99572  1.000 33.07150 ? 363 LEU B CD2   1 
ATOM   1924 N N     . LEU A 1 246 ? -58.63524 20.44051  -6.46662  1.000 32.51663 ? 364 LEU B N     1 
ATOM   1925 C CA    . LEU A 1 246 ? -58.01976 21.26955  -7.50088  1.000 33.46408 ? 364 LEU B CA    1 
ATOM   1926 C C     . LEU A 1 246 ? -58.57900 22.68500  -7.50524  1.000 36.48173 ? 364 LEU B C     1 
ATOM   1927 O O     . LEU A 1 246 ? -58.81896 23.26180  -8.56254  1.000 41.08634 ? 364 LEU B O     1 
ATOM   1928 C CB    . LEU A 1 246 ? -58.19520 20.61931  -8.86728  1.000 34.07961 ? 364 LEU B CB    1 
ATOM   1929 C CG    . LEU A 1 246 ? -57.49300 19.25544  -9.02037  1.000 33.73871 ? 364 LEU B CG    1 
ATOM   1930 C CD1   . LEU A 1 246 ? -57.73595 18.70069  -10.39883 1.000 31.63310 ? 364 LEU B CD1   1 
ATOM   1931 C CD2   . LEU A 1 246 ? -55.96878 19.38690  -8.73300  1.000 32.02967 ? 364 LEU B CD2   1 
ATOM   1932 N N     . LYS A 1 247 ? -58.78940 23.27072  -6.33398  1.000 37.93491 ? 365 LYS B N     1 
ATOM   1933 C CA    . LYS A 1 247 ? -59.18847 24.66947  -6.25321  1.000 38.09375 ? 365 LYS B CA    1 
ATOM   1934 C C     . LYS A 1 247 ? -57.96654 25.55107  -6.40681  1.000 36.29072 ? 365 LYS B C     1 
ATOM   1935 O O     . LYS A 1 247 ? -56.91729 25.27039  -5.82917  1.000 37.31451 ? 365 LYS B O     1 
ATOM   1936 C CB    . LYS A 1 247 ? -59.85582 24.95880  -4.91152  1.000 40.11777 ? 365 LYS B CB    1 
ATOM   1937 C CG    . LYS A 1 247 ? -61.12028 24.18940  -4.71116  1.000 40.81511 ? 365 LYS B CG    1 
ATOM   1938 C CD    . LYS A 1 247 ? -62.30112 24.95017  -5.25687  1.000 43.64064 ? 365 LYS B CD    1 
ATOM   1939 C CE    . LYS A 1 247 ? -63.59505 24.26344  -4.86765  1.000 49.37190 ? 365 LYS B CE    1 
ATOM   1940 N NZ    . LYS A 1 247 ? -64.71954 24.84629  -5.61258  1.000 49.55757 ? 365 LYS B NZ    1 
ATOM   1941 N N     . HIS A 1 248 ? -58.11259 26.62539  -7.18810  1.000 35.95367 ? 366 HIS B N     1 
ATOM   1942 C CA    . HIS A 1 248 ? -57.02336 27.58645  -7.33465  1.000 38.20130 ? 366 HIS B CA    1 
ATOM   1943 C C     . HIS A 1 248 ? -56.61833 28.18344  -5.99323  1.000 42.31228 ? 366 HIS B C     1 
ATOM   1944 O O     . HIS A 1 248 ? -55.42511 28.34339  -5.71338  1.000 44.04871 ? 366 HIS B O     1 
ATOM   1945 C CB    . HIS A 1 248 ? -57.41259 28.70545  -8.30498  1.000 39.02978 ? 366 HIS B CB    1 
ATOM   1946 C CG    . HIS A 1 248 ? -56.27182 29.63019  -8.61384  1.000 42.11485 ? 366 HIS B CG    1 
ATOM   1947 N ND1   . HIS A 1 248 ? -55.96202 30.72132  -7.82497  1.000 45.97164 ? 366 HIS B ND1   1 
ATOM   1948 C CD2   . HIS A 1 248 ? -55.34375 29.60417  -9.59919  1.000 42.19691 ? 366 HIS B CD2   1 
ATOM   1949 C CE1   . HIS A 1 248 ? -54.90482 31.33953  -8.32424  1.000 42.86111 ? 366 HIS B CE1   1 
ATOM   1950 N NE2   . HIS A 1 248 ? -54.50507 30.67763  -9.39840  1.000 45.96818 ? 366 HIS B NE2   1 
ATOM   1951 N N     . ASN A 1 249 ? -57.58912 28.54713  -5.17033  1.000 42.38294 ? 367 ASN B N     1 
ATOM   1952 C CA    . ASN A 1 249 ? -57.34503 29.11640  -3.84239  1.000 41.53847 ? 367 ASN B CA    1 
ATOM   1953 C C     . ASN A 1 249 ? -56.98573 28.03133  -2.84132  1.000 36.43612 ? 367 ASN B C     1 
ATOM   1954 O O     . ASN A 1 249 ? -57.85111 27.23253  -2.48202  1.000 39.11806 ? 367 ASN B O     1 
ATOM   1955 C CB    . ASN A 1 249 ? -58.58693 29.88343  -3.37932  1.000 42.74708 ? 367 ASN B CB    1 
ATOM   1956 C CG    . ASN A 1 249 ? -58.42494 30.50710  -1.98021  1.000 48.62680 ? 367 ASN B CG    1 
ATOM   1957 O OD1   . ASN A 1 249 ? -57.37234 30.43705  -1.35324  1.000 45.35388 ? 367 ASN B OD1   1 
ATOM   1958 N ND2   . ASN A 1 249 ? -59.49059 31.13807  -1.50462  1.000 54.56515 ? 367 ASN B ND2   1 
ATOM   1959 N N     . PRO A 1 250 ? -55.73273 27.96565  -2.37825  1.000 36.95451 ? 368 PRO B N     1 
ATOM   1960 C CA    . PRO A 1 250 ? -55.32686 26.87595  -1.47310  1.000 38.64799 ? 368 PRO B CA    1 
ATOM   1961 C C     . PRO A 1 250 ? -56.19790 26.75159  -0.24153  1.000 41.35591 ? 368 PRO B C     1 
ATOM   1962 O O     . PRO A 1 250 ? -56.44068 25.62780  0.22608   1.000 38.59602 ? 368 PRO B O     1 
ATOM   1963 C CB    . PRO A 1 250 ? -53.88673 27.25179  -1.09618  1.000 39.64263 ? 368 PRO B CB    1 
ATOM   1964 C CG    . PRO A 1 250 ? -53.43021 28.12052  -2.22153  1.000 42.28731 ? 368 PRO B CG    1 
ATOM   1965 C CD    . PRO A 1 250 ? -54.61928 28.89070  -2.65534  1.000 40.53205 ? 368 PRO B CD    1 
ATOM   1966 N N     . SER A 1 251 ? -56.70274 27.88403  0.28133   1.000 42.19627 ? 369 SER B N     1 
ATOM   1967 C CA    . SER A 1 251 ? -57.54531 27.86690  1.47702   1.000 43.08724 ? 369 SER B CA    1 
ATOM   1968 C C     . SER A 1 251 ? -58.83897 27.11455  1.24821   1.000 42.20265 ? 369 SER B C     1 
ATOM   1969 O O     . SER A 1 251 ? -59.43591 26.59932  2.20071   1.000 49.67199 ? 369 SER B O     1 
ATOM   1970 C CB    . SER A 1 251 ? -57.86748 29.29705  1.92375   1.000 44.78899 ? 369 SER B CB    1 
ATOM   1971 O OG    . SER A 1 251 ? -56.68829 29.97505  2.26386   1.000 50.22957 ? 369 SER B OG    1 
ATOM   1972 N N     . GLN A 1 252 ? -59.30273 27.05608  0.00317   1.000 41.92584 ? 370 GLN B N     1 
ATOM   1973 C CA    . GLN A 1 252 ? -60.50634 26.31085  -0.33369  1.000 41.19870 ? 370 GLN B CA    1 
ATOM   1974 C C     . GLN A 1 252 ? -60.29346 24.80655  -0.40059  1.000 42.16188 ? 370 GLN B C     1 
ATOM   1975 O O     . GLN A 1 252 ? -61.28276 24.06407  -0.47227  1.000 44.00358 ? 370 GLN B O     1 
ATOM   1976 C CB    . GLN A 1 252 ? -61.00778 26.78374  -1.68329  1.000 45.27500 ? 370 GLN B CB    1 
ATOM   1977 C CG    . GLN A 1 252 ? -61.13774 28.26685  -1.76676  1.000 51.81766 ? 370 GLN B CG    1 
ATOM   1978 C CD    . GLN A 1 252 ? -62.54305 28.66238  -1.99734  1.000 57.52151 ? 370 GLN B CD    1 
ATOM   1979 O OE1   . GLN A 1 252 ? -63.42723 28.35652  -1.18968  1.000 63.38433 ? 370 GLN B OE1   1 
ATOM   1980 N NE2   . GLN A 1 252 ? -62.78989 29.31467  -3.14375  1.000 61.62015 ? 370 GLN B NE2   1 
ATOM   1981 N N     . ARG A 1 253 ? -59.05249 24.34264  -0.42723  1.000 38.00660 ? 371 ARG B N     1 
ATOM   1982 C CA    . ARG A 1 253 ? -58.85171 22.90486  -0.51623  1.000 37.49903 ? 371 ARG B CA    1 
ATOM   1983 C C     . ARG A 1 253 ? -59.09406 22.23705  0.83795   1.000 40.44306 ? 371 ARG B C     1 
ATOM   1984 O O     . ARG A 1 253 ? -58.78868 22.81468  1.87926   1.000 42.40441 ? 371 ARG B O     1 
ATOM   1985 C CB    . ARG A 1 253 ? -57.43023 22.61231  -0.99128  1.000 35.88569 ? 371 ARG B CB    1 
ATOM   1986 C CG    . ARG A 1 253 ? -57.14720 23.18235  -2.39409  1.000 35.70653 ? 371 ARG B CG    1 
ATOM   1987 C CD    . ARG A 1 253 ? -55.64739 22.98613  -2.83048  1.000 33.14839 ? 371 ARG B CD    1 
ATOM   1988 N NE    . ARG A 1 253 ? -55.32631 23.91342  -3.91576  1.000 33.14137 ? 371 ARG B NE    1 
ATOM   1989 C CZ    . ARG A 1 253 ? -54.16286 24.53399  -4.08857  1.000 34.99539 ? 371 ARG B CZ    1 
ATOM   1990 N NH1   . ARG A 1 253 ? -53.10612 24.25231  -3.34358  1.000 33.86048 ? 371 ARG B NH1   1 
ATOM   1991 N NH2   . ARG A 1 253 ? -54.06280 25.47942  -5.02965  1.000 36.68121 ? 371 ARG B NH2   1 
ATOM   1992 N N     . PRO A 1 254 ? -59.61057 21.01023  0.84654   1.000 38.09737 ? 372 PRO B N     1 
ATOM   1993 C CA    . PRO A 1 254 ? -59.90649 20.34660  2.11462   1.000 41.30791 ? 372 PRO B CA    1 
ATOM   1994 C C     . PRO A 1 254 ? -58.65668 20.05787  2.92933   1.000 39.70412 ? 372 PRO B C     1 
ATOM   1995 O O     . PRO A 1 254 ? -57.51677 20.10716  2.45652   1.000 39.99347 ? 372 PRO B O     1 
ATOM   1996 C CB    . PRO A 1 254 ? -60.60162 19.04315  1.69779   1.000 42.75441 ? 372 PRO B CB    1 
ATOM   1997 C CG    . PRO A 1 254 ? -60.21401 18.83997  0.26955   1.000 43.32903 ? 372 PRO B CG    1 
ATOM   1998 C CD    . PRO A 1 254 ? -60.03188 20.21029  -0.31115  1.000 38.75820 ? 372 PRO B CD    1 
ATOM   1999 N N     . MET A 1 255 ? -58.91414 19.77071  4.19427   1.000 38.16426 ? 373 MET B N     1 
ATOM   2000 C CA    . MET A 1 255 ? -57.94721 19.19795  5.11128   1.000 40.73821 ? 373 MET B CA    1 
ATOM   2001 C C     . MET A 1 255 ? -57.73685 17.73086  4.73486   1.000 38.91069 ? 373 MET B C     1 
ATOM   2002 O O     . MET A 1 255 ? -58.63789 17.08379  4.20274   1.000 37.90097 ? 373 MET B O     1 
ATOM   2003 C CB    . MET A 1 255 ? -58.56003 19.30916  6.50412   1.000 38.87605 ? 373 MET B CB    1 
ATOM   2004 C CG    . MET A 1 255 ? -58.50836 20.73583  7.03516   1.000 43.48256 ? 373 MET B CG    1 
ATOM   2005 S SD    . MET A 1 255 ? -58.75278 20.77221  8.80540   1.000 48.47794 ? 373 MET B SD    1 
ATOM   2006 C CE    . MET A 1 255 ? -60.48557 20.39360  8.85763   1.000 44.72881 ? 373 MET B CE    1 
ATOM   2007 N N     . LEU A 1 256 ? -56.54699 17.18731  5.02563   1.000 37.35881 ? 374 LEU B N     1 
ATOM   2008 C CA    . LEU A 1 256 ? -56.31678 15.77407  4.72838   1.000 40.40512 ? 374 LEU B CA    1 
ATOM   2009 C C     . LEU A 1 256 ? -57.32568 14.87697  5.45232   1.000 42.54359 ? 374 LEU B C     1 
ATOM   2010 O O     . LEU A 1 256 ? -57.79302 13.88155  4.88991   1.000 38.93978 ? 374 LEU B O     1 
ATOM   2011 C CB    . LEU A 1 256 ? -54.88273 15.37588  5.09159   1.000 39.98321 ? 374 LEU B CB    1 
ATOM   2012 C CG    . LEU A 1 256 ? -53.79348 15.91010  4.15391   1.000 40.68806 ? 374 LEU B CG    1 
ATOM   2013 C CD1   . LEU A 1 256 ? -52.38670 15.72215  4.75757   1.000 39.85261 ? 374 LEU B CD1   1 
ATOM   2014 C CD2   . LEU A 1 256 ? -53.89050 15.21071  2.80400   1.000 38.33062 ? 374 LEU B CD2   1 
ATOM   2015 N N     . ARG A 1 257 ? -57.68750 15.21268  6.69867   1.000 40.66572 ? 375 ARG B N     1 
ATOM   2016 C CA    . ARG A 1 257 ? -58.69822 14.41006  7.39132   1.000 44.54748 ? 375 ARG B CA    1 
ATOM   2017 C C     . ARG A 1 257 ? -60.05168 14.49558  6.69362   1.000 43.84010 ? 375 ARG B C     1 
ATOM   2018 O O     . ARG A 1 257 ? -60.85385 13.55312  6.76456   1.000 45.52554 ? 375 ARG B O     1 
ATOM   2019 C CB    . ARG A 1 257 ? -58.79404 14.83354  8.86838   1.000 45.47898 ? 375 ARG B CB    1 
ATOM   2020 C CG    . ARG A 1 257 ? -59.62339 16.09116  9.15052   1.000 44.13810 ? 375 ARG B CG    1 
ATOM   2021 C CD    . ARG A 1 257 ? -59.96959 16.17926  10.63389  1.000 47.93932 ? 375 ARG B CD    1 
ATOM   2022 N NE    . ARG A 1 257 ? -60.43366 17.50578  11.03939  1.000 45.24120 ? 375 ARG B NE    1 
ATOM   2023 C CZ    . ARG A 1 257 ? -61.69950 17.89359  10.98004  1.000 47.97117 ? 375 ARG B CZ    1 
ATOM   2024 N NH1   . ARG A 1 257 ? -62.63225 17.12148  10.44354  1.000 49.86007 ? 375 ARG B NH1   1 
ATOM   2025 N NH2   . ARG A 1 257 ? -62.03985 19.08835  11.46605  1.000 44.59797 ? 375 ARG B NH2   1 
ATOM   2026 N N     . GLU A 1 258 ? -60.30881 15.58840  5.98215   1.000 42.18212 ? 376 GLU B N     1 
ATOM   2027 C CA    . GLU A 1 258 ? -61.55274 15.69194  5.23376   1.000 43.48698 ? 376 GLU B CA    1 
ATOM   2028 C C     . GLU A 1 258 ? -61.50655 14.88833  3.94006   1.000 45.02020 ? 376 GLU B C     1 
ATOM   2029 O O     . GLU A 1 258 ? -62.55431 14.43314  3.46510   1.000 45.56870 ? 376 GLU B O     1 
ATOM   2030 C CB    . GLU A 1 258 ? -61.86901 17.15471  4.93560   1.000 43.90020 ? 376 GLU B CB    1 
ATOM   2031 C CG    . GLU A 1 258 ? -62.22376 17.95188  6.17571   1.000 45.76106 ? 376 GLU B CG    1 
ATOM   2032 C CD    . GLU A 1 258 ? -62.42837 19.40902  5.85980   1.000 46.03812 ? 376 GLU B CD    1 
ATOM   2033 O OE1   . GLU A 1 258 ? -61.58944 19.96768  5.11809   1.000 45.21346 ? 376 GLU B OE1   1 
ATOM   2034 O OE2   . GLU A 1 258 ? -63.42332 20.00656  6.34356   1.000 47.97564 ? 376 GLU B OE2   1 
ATOM   2035 N N     . VAL A 1 259 ? -60.32012 14.71062  3.35040   1.000 40.74681 ? 377 VAL B N     1 
ATOM   2036 C CA    . VAL A 1 259 ? -60.18577 13.75072  2.25268   1.000 40.19768 ? 377 VAL B CA    1 
ATOM   2037 C C     . VAL A 1 259 ? -60.47559 12.34435  2.75681   1.000 41.82576 ? 377 VAL B C     1 
ATOM   2038 O O     . VAL A 1 259 ? -61.22297 11.57873  2.13740   1.000 39.61056 ? 377 VAL B O     1 
ATOM   2039 C CB    . VAL A 1 259 ? -58.78004 13.82184  1.62632   1.000 38.24444 ? 377 VAL B CB    1 
ATOM   2040 C CG1   . VAL A 1 259 ? -58.55285 12.62513  0.64908   1.000 35.22407 ? 377 VAL B CG1   1 
ATOM   2041 C CG2   . VAL A 1 259 ? -58.55666 15.15800  0.93365   1.000 37.23931 ? 377 VAL B CG2   1 
ATOM   2042 N N     . LEU A 1 260 ? -59.89465 11.98718  3.90142   1.000 41.74741 ? 378 LEU B N     1 
ATOM   2043 C CA    . LEU A 1 260 ? -60.00426 10.61325  4.37900   1.000 41.82528 ? 378 LEU B CA    1 
ATOM   2044 C C     . LEU A 1 260 ? -61.43680 10.24885  4.72996   1.000 47.96990 ? 378 LEU B C     1 
ATOM   2045 O O     . LEU A 1 260 ? -61.79151 9.06530   4.68427   1.000 49.47506 ? 378 LEU B O     1 
ATOM   2046 C CB    . LEU A 1 260 ? -59.09239 10.40959  5.58198   1.000 40.83896 ? 378 LEU B CB    1 
ATOM   2047 C CG    . LEU A 1 260 ? -57.59086 10.34577  5.27215   1.000 45.18968 ? 378 LEU B CG    1 
ATOM   2048 C CD1   . LEU A 1 260 ? -56.76040 10.72029  6.47658   1.000 48.01441 ? 378 LEU B CD1   1 
ATOM   2049 C CD2   . LEU A 1 260 ? -57.18937 8.96599   4.77566   1.000 43.15883 ? 378 LEU B CD2   1 
ATOM   2050 N N     . GLU A 1 261 ? -62.26793 11.24143  5.02990   1.000 45.68073 ? 379 GLU B N     1 
ATOM   2051 C CA    . GLU A 1 261 ? -63.66837 11.05688  5.39372   1.000 49.63933 ? 379 GLU B CA    1 
ATOM   2052 C C     . GLU A 1 261 ? -64.62236 11.34973  4.24323   1.000 48.52161 ? 379 GLU B C     1 
ATOM   2053 O O     . GLU A 1 261 ? -65.83991 11.22186  4.41726   1.000 48.04004 ? 379 GLU B O     1 
ATOM   2054 C CB    . GLU A 1 261 ? -63.99785 11.94721  6.61155   1.000 53.31744 ? 379 GLU B CB    1 
ATOM   2055 C CG    . GLU A 1 261 ? -64.03626 13.43811  6.27032   1.000 55.34633 ? 379 GLU B CG    1 
ATOM   2056 C CD    . GLU A 1 261 ? -64.14852 14.38405  7.48464   1.000 59.68468 ? 379 GLU B CD    1 
ATOM   2057 O OE1   . GLU A 1 261 ? -63.28187 14.32093  8.40102   1.000 59.23243 ? 379 GLU B OE1   1 
ATOM   2058 O OE2   . GLU A 1 261 ? -65.07072 15.23744  7.48415   1.000 61.16027 ? 379 GLU B OE2   1 
ATOM   2059 N N     . HIS A 1 262 ? -64.10955 11.72137  3.07002   1.000 44.83987 ? 380 HIS B N     1 
ATOM   2060 C CA    . HIS A 1 262 ? -64.98894 12.05848  1.96180   1.000 44.47568 ? 380 HIS B CA    1 
ATOM   2061 C C     . HIS A 1 262 ? -65.84985 10.84548  1.61157   1.000 45.02054 ? 380 HIS B C     1 
ATOM   2062 O O     . HIS A 1 262 ? -65.35373 9.71610   1.62856   1.000 42.53424 ? 380 HIS B O     1 
ATOM   2063 C CB    . HIS A 1 262 ? -64.17481 12.49627  0.74337   1.000 43.72077 ? 380 HIS B CB    1 
ATOM   2064 C CG    . HIS A 1 262 ? -65.00089 13.04644  -0.38027  1.000 39.81068 ? 380 HIS B CG    1 
ATOM   2065 N ND1   . HIS A 1 262 ? -65.67269 12.24198  -1.27418  1.000 38.98992 ? 380 HIS B ND1   1 
ATOM   2066 C CD2   . HIS A 1 262 ? -65.23006 14.32026  -0.77800  1.000 40.61859 ? 380 HIS B CD2   1 
ATOM   2067 C CE1   . HIS A 1 262 ? -66.28413 12.99381  -2.17032  1.000 39.89920 ? 380 HIS B CE1   1 
ATOM   2068 N NE2   . HIS A 1 262 ? -66.02504 14.26088  -1.89537  1.000 40.32545 ? 380 HIS B NE2   1 
ATOM   2069 N N     . PRO A 1 263 ? -67.14296 11.04080  1.30791   1.000 48.02399 ? 381 PRO B N     1 
ATOM   2070 C CA    . PRO A 1 263 ? -68.02753 9.88082   1.07987   1.000 45.34804 ? 381 PRO B CA    1 
ATOM   2071 C C     . PRO A 1 263 ? -67.58201 8.97246   -0.04771  1.000 48.22778 ? 381 PRO B C     1 
ATOM   2072 O O     . PRO A 1 263 ? -67.81873 7.75847   0.01632   1.000 45.82862 ? 381 PRO B O     1 
ATOM   2073 C CB    . PRO A 1 263 ? -69.38017 10.53202  0.76175   1.000 47.19222 ? 381 PRO B CB    1 
ATOM   2074 C CG    . PRO A 1 263 ? -69.29521 11.89700  1.35816   1.000 48.55435 ? 381 PRO B CG    1 
ATOM   2075 C CD    . PRO A 1 263 ? -67.86521 12.31586  1.19544   1.000 43.67031 ? 381 PRO B CD    1 
ATOM   2076 N N     . TRP A 1 264 ? -66.96517 9.52610   -1.09431  1.000 43.25956 ? 382 TRP B N     1 
ATOM   2077 C CA    . TRP A 1 264 ? -66.48476 8.69118   -2.19068  1.000 44.29232 ? 382 TRP B CA    1 
ATOM   2078 C C     . TRP A 1 264 ? -65.28882 7.84900   -1.75266  1.000 43.82395 ? 382 TRP B C     1 
ATOM   2079 O O     . TRP A 1 264 ? -65.15933 6.68057   -2.14556  1.000 44.71411 ? 382 TRP B O     1 
ATOM   2080 C CB    . TRP A 1 264 ? -66.14359 9.57588   -3.39567  1.000 39.63849 ? 382 TRP B CB    1 
ATOM   2081 C CG    . TRP A 1 264 ? -65.68225 8.82343   -4.59497  1.000 41.93374 ? 382 TRP B CG    1 
ATOM   2082 C CD1   . TRP A 1 264 ? -66.46588 8.19282   -5.53633  1.000 42.55452 ? 382 TRP B CD1   1 
ATOM   2083 C CD2   . TRP A 1 264 ? -64.32249 8.60397   -4.99552  1.000 44.73824 ? 382 TRP B CD2   1 
ATOM   2084 N NE1   . TRP A 1 264 ? -65.66841 7.60075   -6.48652  1.000 43.92155 ? 382 TRP B NE1   1 
ATOM   2085 C CE2   . TRP A 1 264 ? -64.35252 7.83666   -6.17923  1.000 43.88675 ? 382 TRP B CE2   1 
ATOM   2086 C CE3   . TRP A 1 264 ? -63.08541 8.98574   -4.46935  1.000 42.06601 ? 382 TRP B CE3   1 
ATOM   2087 C CZ2   . TRP A 1 264 ? -63.19377 7.45254   -6.84911  1.000 41.80561 ? 382 TRP B CZ2   1 
ATOM   2088 C CZ3   . TRP A 1 264 ? -61.93171 8.59508   -5.13399  1.000 42.87499 ? 382 TRP B CZ3   1 
ATOM   2089 C CH2   . TRP A 1 264 ? -61.99585 7.83737   -6.31235  1.000 41.17772 ? 382 TRP B CH2   1 
ATOM   2090 N N     . ILE A 1 265 ? -64.41882 8.41188   -0.90986  1.000 42.06279 ? 383 ILE B N     1 
ATOM   2091 C CA    . ILE A 1 265 ? -63.30499 7.63551   -0.37347  1.000 45.46885 ? 383 ILE B CA    1 
ATOM   2092 C C     . ILE A 1 265 ? -63.80971 6.51340   0.53638   1.000 45.79923 ? 383 ILE B C     1 
ATOM   2093 O O     . ILE A 1 265 ? -63.36457 5.36393   0.43838   1.000 47.03527 ? 383 ILE B O     1 
ATOM   2094 C CB    . ILE A 1 265 ? -62.31933 8.56288   0.35751   1.000 45.90579 ? 383 ILE B CB    1 
ATOM   2095 C CG1   . ILE A 1 265 ? -61.64436 9.48843   -0.66148  1.000 40.42728 ? 383 ILE B CG1   1 
ATOM   2096 C CG2   . ILE A 1 265 ? -61.31845 7.74304   1.15622   1.000 44.80729 ? 383 ILE B CG2   1 
ATOM   2097 C CD1   . ILE A 1 265 ? -60.72673 8.71745   -1.63611  1.000 39.96837 ? 383 ILE B CD1   1 
ATOM   2098 N N     . THR A 1 266 ? -64.73360 6.82669   1.44285   1.000 45.54930 ? 384 THR B N     1 
ATOM   2099 C CA    . THR A 1 266 ? -65.13527 5.81363   2.41117   1.000 47.26182 ? 384 THR B CA    1 
ATOM   2100 C C     . THR A 1 266 ? -65.99250 4.73793   1.76381   1.000 49.01503 ? 384 THR B C     1 
ATOM   2101 O O     . THR A 1 266 ? -66.00317 3.59657   2.23650   1.000 51.79391 ? 384 THR B O     1 
ATOM   2102 C CB    . THR A 1 266 ? -65.86475 6.46140   3.58621   1.000 48.06054 ? 384 THR B CB    1 
ATOM   2103 O OG1   . THR A 1 266 ? -67.05267 7.10411   3.11998   1.000 50.44802 ? 384 THR B OG1   1 
ATOM   2104 C CG2   . THR A 1 266 ? -64.97522 7.49350   4.23719   1.000 50.72555 ? 384 THR B CG2   1 
ATOM   2105 N N     . ALA A 1 267 ? -66.68196 5.07040   0.66774   1.000 49.62158 ? 385 ALA B N     1 
ATOM   2106 C CA    . ALA A 1 267 ? -67.49767 4.08185   -0.03025  1.000 49.57152 ? 385 ALA B CA    1 
ATOM   2107 C C     . ALA A 1 267 ? -66.64808 3.09944   -0.82833  1.000 52.93527 ? 385 ALA B C     1 
ATOM   2108 O O     . ALA A 1 267 ? -67.05652 1.95110   -1.02827  1.000 51.63286 ? 385 ALA B O     1 
ATOM   2109 C CB    . ALA A 1 267 ? -68.48468 4.78444   -0.95840  1.000 48.49897 ? 385 ALA B CB    1 
ATOM   2110 N N     . ASN A 1 268 ? -65.46519 3.51970   -1.29565  1.000 50.36974 ? 386 ASN B N     1 
ATOM   2111 C CA    . ASN A 1 268 ? -64.68947 2.72005   -2.23142  1.000 48.51292 ? 386 ASN B CA    1 
ATOM   2112 C C     . ASN A 1 268 ? -63.37068 2.19389   -1.69929  1.000 49.55243 ? 386 ASN B C     1 
ATOM   2113 O O     . ASN A 1 268 ? -62.84015 1.24030   -2.26750  1.000 50.17754 ? 386 ASN B O     1 
ATOM   2114 C CB    . ASN A 1 268 ? -64.41440 3.52418   -3.50995  1.000 48.60720 ? 386 ASN B CB    1 
ATOM   2115 C CG    . ASN A 1 268 ? -65.66970 3.82025   -4.27038  1.000 49.74657 ? 386 ASN B CG    1 
ATOM   2116 O OD1   . ASN A 1 268 ? -66.25080 2.92515   -4.87764  1.000 51.30413 ? 386 ASN B OD1   1 
ATOM   2117 N ND2   . ASN A 1 268 ? -66.09786 5.08218   -4.26044  1.000 46.09492 ? 386 ASN B ND2   1 
ATOM   2118 N N     . SER A 1 269 ? -62.81788 2.77433   -0.64891  1.000 52.42404 ? 387 SER B N     1 
ATOM   2119 C CA    . SER A 1 269 ? -61.46918 2.40583   -0.26760  1.000 49.80247 ? 387 SER B CA    1 
ATOM   2120 C C     . SER A 1 269 ? -61.44668 1.05837   0.44704   1.000 55.62476 ? 387 SER B C     1 
ATOM   2121 O O     . SER A 1 269 ? -62.38967 0.68421   1.14854   1.000 54.50004 ? 387 SER B O     1 
ATOM   2122 C CB    . SER A 1 269 ? -60.86073 3.47122   0.63708   1.000 49.06114 ? 387 SER B CB    1 
ATOM   2123 O OG    . SER A 1 269 ? -59.60385 3.02794   1.11053   1.000 52.41035 ? 387 SER B OG    1 
ATOM   2124 N N     . SER A 1 270 ? -60.35772 0.32316   0.24770   1.000 56.67681 ? 388 SER B N     1 
ATOM   2125 C CA    . SER A 1 270 ? -60.00705 -0.79027  1.13274   1.000 61.67267 ? 388 SER B CA    1 
ATOM   2126 C C     . SER A 1 270 ? -59.50355 -0.22411  2.46022   1.000 61.89480 ? 388 SER B C     1 
ATOM   2127 O O     . SER A 1 270 ? -59.80139 -0.74875  3.53470   1.000 70.49719 ? 388 SER B O     1 
ATOM   2128 C CB    . SER A 1 270 ? -58.92881 -1.69242  0.51334   1.000 60.60841 ? 388 SER B CB    1 
ATOM   2129 O OG    . SER A 1 270 ? -59.34641 -2.24051  -0.72419  1.000 64.50929 ? 388 SER B OG    1 
HETATM 2130 N N1    . OGR B 2 .   ? -37.18554 7.19916   -6.97720  1.000 39.04040 ? 501 OGR B N1    1 
HETATM 2131 N N3    . OGR B 2 .   ? -37.22861 0.49188   -5.24033  1.000 35.54019 ? 501 OGR B N3    1 
HETATM 2132 C C5    . OGR B 2 .   ? -36.32877 4.91029   -6.37103  1.000 35.70418 ? 501 OGR B C5    1 
HETATM 2133 C C6    . OGR B 2 .   ? -36.07352 6.34127   -6.57825  1.000 34.58723 ? 501 OGR B C6    1 
HETATM 2134 C C7    . OGR B 2 .   ? -36.82730 1.63817   -4.67947  1.000 36.84054 ? 501 OGR B C7    1 
HETATM 2135 C C8    . OGR B 2 .   ? -36.67343 2.84072   -5.39677  1.000 36.59953 ? 501 OGR B C8    1 
HETATM 2136 C C13   . OGR B 2 .   ? -36.53580 3.42471   -11.10685 1.000 38.60636 ? 501 OGR B C13   1 
HETATM 2137 C C15   . OGR B 2 .   ? -38.29537 3.84750   -9.36474  1.000 35.54259 ? 501 OGR B C15   1 
HETATM 2138 C C1    . OGR B 2 .   ? -39.88925 -3.71811  -14.61362 1.000 60.31586 ? 501 OGR B C1    1 
HETATM 2139 C "C1'" . OGR B 2 .   ? -38.23063 -1.15246  -8.43543  1.000 41.26043 ? 501 OGR B "C1'" 1 
HETATM 2140 C C11   . OGR B 2 .   ? -36.92130 4.25930   -8.85068  1.000 35.99401 ? 501 OGR B C11   1 
HETATM 2141 C C12   . OGR B 2 .   ? -35.86645 3.54897   -9.70954  1.000 38.27692 ? 501 OGR B C12   1 
HETATM 2142 C C14   . OGR B 2 .   ? -38.06817 3.42420   -10.85785 1.000 40.73540 ? 501 OGR B C14   1 
HETATM 2143 C C16   . OGR B 2 .   ? -36.96295 2.71233   -6.82069  1.000 35.13810 ? 501 OGR B C16   1 
HETATM 2144 C C18   . OGR B 2 .   ? -37.03304 8.65300   -7.18530  1.000 35.72321 ? 501 OGR B C18   1 
HETATM 2145 C C19   . OGR B 2 .   ? -38.54521 6.62334   -7.15042  1.000 35.95239 ? 501 OGR B C19   1 
HETATM 2146 C C2    . OGR B 2 .   ? -39.36357 -2.24928  -12.57610 1.000 53.22125 ? 501 OGR B C2    1 
HETATM 2147 C "C2'" . OGR B 2 .   ? -38.09945 -0.25654  -9.53546  1.000 40.76177 ? 501 OGR B "C2'" 1 
HETATM 2148 C "C3'" . OGR B 2 .   ? -38.48553 -0.67402  -10.83270 1.000 46.71043 ? 501 OGR B "C3'" 1 
HETATM 2149 C "C4'" . OGR B 2 .   ? -38.97813 -1.92193  -11.14120 1.000 51.61379 ? 501 OGR B "C4'" 1 
HETATM 2150 C "C5'" . OGR B 2 .   ? -39.07206 -2.77750  -10.00373 1.000 44.98756 ? 501 OGR B "C5'" 1 
HETATM 2151 C C9    . OGR B 2 .   ? -36.29262 4.20856   -5.16025  1.000 36.24215 ? 501 OGR B C9    1 
HETATM 2152 C CAA   . OGR B 2 .   ? -37.47414 0.43888   -6.60505  1.000 39.80108 ? 501 OGR B CAA   1 
HETATM 2153 N N2    . OGR B 2 .   ? -39.49486 -3.50797  -13.17819 1.000 58.78251 ? 501 OGR B N2    1 
HETATM 2154 N N6    . OGR B 2 .   ? -37.33915 1.57138   -7.39100  1.000 34.33409 ? 501 OGR B N6    1 
HETATM 2155 N N7    . OGR B 2 .   ? -36.75090 3.96127   -7.33920  1.000 37.30520 ? 501 OGR B N7    1 
HETATM 2156 N N9    . OGR B 2 .   ? -37.86402 -0.79701  -7.09774  1.000 39.99808 ? 501 OGR B N9    1 
HETATM 2157 N NAA   . OGR B 2 .   ? -38.71202 -2.39154  -8.73392  1.000 47.04340 ? 501 OGR B NAA   1 
HETATM 2158 O O6    . OGR B 2 .   ? -34.97674 6.87743   -6.39286  1.000 37.67891 ? 501 OGR B O6    1 
HETATM 2159 O OP3   . OGR B 2 .   ? -39.60174 -1.27414  -13.31932 1.000 55.38042 ? 501 OGR B OP3   1 
HETATM 2160 O O     . HOH C 3 .   ? -33.62944 13.84855  -11.50674 1.000 47.34353 ? 601 HOH B O     1 
HETATM 2161 O O     . HOH C 3 .   ? -48.46046 11.98884  -19.55907 1.000 48.85577 ? 602 HOH B O     1 
HETATM 2162 O O     . HOH C 3 .   ? -58.92970 0.99824   4.76555   1.000 72.95746 ? 603 HOH B O     1 
HETATM 2163 O O     . HOH C 3 .   ? -32.18641 -7.28631  -13.26049 1.000 50.34676 ? 604 HOH B O     1 
HETATM 2164 O O     . HOH C 3 .   ? -44.10474 -4.33235  1.21324   1.000 66.12552 ? 605 HOH B O     1 
HETATM 2165 O O     . HOH C 3 .   ? -44.15424 28.99704  -4.31648  1.000 50.84710 ? 606 HOH B O     1 
HETATM 2166 O O     . HOH C 3 .   ? -68.87894 5.37480   -7.40074  1.000 48.46131 ? 607 HOH B O     1 
HETATM 2167 O O     . HOH C 3 .   ? -29.89581 -6.75387  -11.71067 1.000 49.49596 ? 608 HOH B O     1 
HETATM 2168 O O     . HOH C 3 .   ? -20.42582 -11.29164 -2.56478  1.000 51.49019 ? 609 HOH B O     1 
HETATM 2169 O O     . HOH C 3 .   ? -52.10843 -0.79430  -1.54429  1.000 54.68627 ? 610 HOH B O     1 
HETATM 2170 O O     . HOH C 3 .   ? -42.13102 2.92637   -16.45754 1.000 41.07862 ? 611 HOH B O     1 
HETATM 2171 O O     . HOH C 3 .   ? -45.17104 -1.27969  -11.22146 1.000 44.68839 ? 612 HOH B O     1 
HETATM 2172 O O     . HOH C 3 .   ? -50.56826 30.25865  -1.65882  1.000 49.91012 ? 613 HOH B O     1 
HETATM 2173 O O     . HOH C 3 .   ? -47.21805 15.11445  -19.52847 1.000 49.52408 ? 614 HOH B O     1 
HETATM 2174 O O     . HOH C 3 .   ? -47.13584 17.83549  -3.32631  1.000 39.00912 ? 615 HOH B O     1 
HETATM 2175 O O     . HOH C 3 .   ? -32.02165 11.35602  -8.41098  1.000 46.94470 ? 616 HOH B O     1 
HETATM 2176 O O     . HOH C 3 .   ? -62.65228 22.84259  -8.71448  1.000 44.53459 ? 617 HOH B O     1 
HETATM 2177 O O     . HOH C 3 .   ? -50.79588 29.69341  4.59937   1.000 38.80856 ? 618 HOH B O     1 
HETATM 2178 O O     . HOH C 3 .   ? -55.33750 18.35051  -20.86550 1.000 43.95605 ? 619 HOH B O     1 
HETATM 2179 O O     . HOH C 3 .   ? -41.59016 3.46221   -13.85736 1.000 37.54239 ? 620 HOH B O     1 
HETATM 2180 O O     . HOH C 3 .   ? -39.27725 6.63049   -11.35296 1.000 38.64666 ? 621 HOH B O     1 
HETATM 2181 O O     . HOH C 3 .   ? -57.98099 -1.06254  -13.97958 1.000 50.71038 ? 622 HOH B O     1 
HETATM 2182 O O     . HOH C 3 .   ? -50.33266 8.33175   -17.26007 1.000 47.30958 ? 623 HOH B O     1 
HETATM 2183 O O     . HOH C 3 .   ? -55.39616 15.54551  -19.80410 1.000 46.30289 ? 624 HOH B O     1 
HETATM 2184 O O     . HOH C 3 .   ? -40.77521 8.07208   -15.13571 1.000 51.72171 ? 625 HOH B O     1 
HETATM 2185 O O     . HOH C 3 .   ? -41.12622 0.75994   -12.53420 1.000 45.91653 ? 626 HOH B O     1 
HETATM 2186 O O     . HOH C 3 .   ? -65.08183 15.15759  3.88000   1.000 48.67103 ? 627 HOH B O     1 
HETATM 2187 O O     . HOH C 3 .   ? -66.71991 20.45983  -10.69678 1.000 49.99782 ? 628 HOH B O     1 
HETATM 2188 O O     . HOH C 3 .   ? -38.36436 17.31864  -10.61793 1.000 50.20072 ? 629 HOH B O     1 
HETATM 2189 O O     . HOH C 3 .   ? -53.60699 25.95565  -23.28159 1.000 54.76518 ? 630 HOH B O     1 
HETATM 2190 O O     . HOH C 3 .   ? -55.62827 28.76256  4.39536   1.000 48.92168 ? 631 HOH B O     1 
HETATM 2191 O O     . HOH C 3 .   ? -36.15252 -0.81653  -13.78471 1.000 48.64830 ? 632 HOH B O     1 
HETATM 2192 O O     . HOH C 3 .   ? -38.85244 9.33592   -10.41136 1.000 39.96719 ? 633 HOH B O     1 
HETATM 2193 O O     . HOH C 3 .   ? -60.09840 29.47486  -15.79292 1.000 50.50672 ? 634 HOH B O     1 
HETATM 2194 O O     . HOH C 3 .   ? -50.11107 26.83470  -1.00809  1.000 41.01826 ? 635 HOH B O     1 
HETATM 2195 O O     . HOH C 3 .   ? -39.17335 14.49360  -8.09044  1.000 47.01043 ? 636 HOH B O     1 
HETATM 2196 O O     . HOH C 3 .   ? -41.64602 1.79091   4.33828   1.000 44.43138 ? 637 HOH B O     1 
HETATM 2197 O O     . HOH C 3 .   ? -53.69731 28.55817  2.11373   1.000 47.01022 ? 638 HOH B O     1 
HETATM 2198 O O     . HOH C 3 .   ? -61.43017 4.84409   -13.92139 1.000 39.18375 ? 639 HOH B O     1 
HETATM 2199 O O     . HOH C 3 .   ? -36.39781 7.79698   -3.16396  1.000 40.32812 ? 640 HOH B O     1 
HETATM 2200 O O     . HOH C 3 .   ? -41.624   10.265    -24.478   1.000 52.95809 ? 641 HOH B O     1 
HETATM 2201 O O     . HOH C 3 .   ? -41.29816 12.36965  -14.31300 1.000 39.60081 ? 642 HOH B O     1 
HETATM 2202 O O     . HOH C 3 .   ? -28.50594 23.89351  -1.91597  1.000 62.85561 ? 643 HOH B O     1 
HETATM 2203 O O     . HOH C 3 .   ? -51.31261 -2.24995  -4.98430  1.000 46.24721 ? 644 HOH B O     1 
HETATM 2204 O O     . HOH C 3 .   ? -42.35585 -4.40003  0.61879   1.000 55.26518 ? 645 HOH B O     1 
HETATM 2205 O O     . HOH C 3 .   ? -52.90638 29.30194  -6.08745  1.000 45.82012 ? 646 HOH B O     1 
HETATM 2206 O O     . HOH C 3 .   ? -56.18510 20.85102  -19.69658 1.000 42.92520 ? 647 HOH B O     1 
HETATM 2207 O O     . HOH C 3 .   ? -40.77831 -2.24762  0.03067   1.000 47.56780 ? 648 HOH B O     1 
HETATM 2208 O O     . HOH C 3 .   ? -68.02400 15.15408  -18.60303 1.000 44.22026 ? 649 HOH B O     1 
HETATM 2209 O O     . HOH C 3 .   ? -44.42197 18.18361  -8.90178  1.000 37.57141 ? 650 HOH B O     1 
HETATM 2210 O O     . HOH C 3 .   ? -52.61760 5.63070   -19.03062 1.000 48.29267 ? 651 HOH B O     1 
HETATM 2211 O O     . HOH C 3 .   ? -70.19300 15.86124  -8.33057  1.000 51.89935 ? 652 HOH B O     1 
HETATM 2212 O O     . HOH C 3 .   ? -50.64255 20.47787  -11.59884 1.000 31.72150 ? 653 HOH B O     1 
HETATM 2213 O O     . HOH C 3 .   ? -36.64356 15.40401  -9.18551  1.000 45.00703 ? 654 HOH B O     1 
HETATM 2214 O O     . HOH C 3 .   ? -46.53734 8.66047   -20.12864 1.000 47.91141 ? 655 HOH B O     1 
HETATM 2215 O O     . HOH C 3 .   ? -28.228   -12.747   -7.332    1.000 36.66857 ? 656 HOH B O     1 
HETATM 2216 O O     . HOH C 3 .   ? -54.91230 21.50913  5.18863   1.000 47.11336 ? 657 HOH B O     1 
HETATM 2217 O O     . HOH C 3 .   ? -33.48502 4.17780   -17.18713 1.000 43.25003 ? 658 HOH B O     1 
HETATM 2218 O O     . HOH C 3 .   ? -40.64272 4.94260   6.46507   1.000 48.30713 ? 659 HOH B O     1 
HETATM 2219 O O     . HOH C 3 .   ? -19.01094 13.22947  -9.14905  1.000 56.81829 ? 660 HOH B O     1 
HETATM 2220 O O     . HOH C 3 .   ? -51.23063 17.71339  -15.22102 1.000 35.78673 ? 661 HOH B O     1 
HETATM 2221 O O     . HOH C 3 .   ? -37.82588 -5.07249  0.14651   1.000 48.81420 ? 662 HOH B O     1 
HETATM 2222 O O     . HOH C 3 .   ? -41.57642 -5.69987  -10.41185 1.000 51.51804 ? 663 HOH B O     1 
HETATM 2223 O O     . HOH C 3 .   ? -39.23742 9.72487   -15.45948 1.000 46.86173 ? 664 HOH B O     1 
HETATM 2224 O O     . HOH C 3 .   ? -50.79948 16.60601  10.05872  1.000 50.52445 ? 665 HOH B O     1 
HETATM 2225 O O     . HOH C 3 .   ? -65.44650 17.65468  10.34938  1.000 54.47914 ? 666 HOH B O     1 
HETATM 2226 O O     . HOH C 3 .   ? -31.59700 12.53805  -10.40390 1.000 46.21411 ? 667 HOH B O     1 
HETATM 2227 O O     . HOH C 3 .   ? -16.67073 5.09931   1.58743   1.000 57.92545 ? 668 HOH B O     1 
HETATM 2228 O O     . HOH C 3 .   ? -54.104   23.137    7.451     1.000 50.34567 ? 669 HOH B O     1 
HETATM 2229 O O     . HOH C 3 .   ? -35.24452 -3.26488  1.03346   1.000 42.89468 ? 670 HOH B O     1 
HETATM 2230 O O     . HOH C 3 .   ? -46.51988 16.31311  -6.50820  1.000 38.84114 ? 671 HOH B O     1 
HETATM 2231 O O     . HOH C 3 .   ? -64.82751 7.78603   -11.28160 1.000 39.47729 ? 672 HOH B O     1 
HETATM 2232 O O     . HOH C 3 .   ? -28.95697 -14.37669 -2.43050  1.000 58.01534 ? 673 HOH B O     1 
HETATM 2233 O O     . HOH C 3 .   ? -45.65790 19.05172  -22.81730 1.000 49.11408 ? 674 HOH B O     1 
HETATM 2234 O O     . HOH C 3 .   ? -54.65138 18.97811  6.33335   1.000 45.04625 ? 675 HOH B O     1 
HETATM 2235 O O     . HOH C 3 .   ? -23.15488 -14.34200 -4.38042  1.000 48.18088 ? 676 HOH B O     1 
HETATM 2236 O O     . HOH C 3 .   ? -64.94467 24.06961  -8.42518  1.000 52.95420 ? 677 HOH B O     1 
HETATM 2237 O O     . HOH C 3 .   ? -65.94124 10.99260  -22.34858 1.000 52.83227 ? 678 HOH B O     1 
HETATM 2238 O O     . HOH C 3 .   ? -39.26709 9.28875   0.10928   1.000 41.06278 ? 679 HOH B O     1 
HETATM 2239 O O     . HOH C 3 .   ? -52.16220 18.73635  7.21059   1.000 48.16876 ? 680 HOH B O     1 
HETATM 2240 O O     . HOH C 3 .   ? -25.97035 -13.23526 -5.27518  1.000 43.39879 ? 681 HOH B O     1 
HETATM 2241 O O     . HOH C 3 .   ? -39.14991 16.35300  -3.88109  1.000 52.87587 ? 682 HOH B O     1 
HETATM 2242 O O     . HOH C 3 .   ? -65.51057 18.64841  7.95352   1.000 51.92970 ? 683 HOH B O     1 
HETATM 2243 O O     . HOH C 3 .   ? -64.47785 1.51924   -10.91800 1.000 52.01551 ? 684 HOH B O     1 
HETATM 2244 O O     . HOH C 3 .   ? -54.88793 14.88025  9.41995   1.000 53.58907 ? 685 HOH B O     1 
HETATM 2245 O O     . HOH C 3 .   ? -39.89646 5.75055   -14.05354 1.000 37.37509 ? 686 HOH B O     1 
HETATM 2246 O O     . HOH C 3 .   ? -56.08447 16.91451  8.56283   1.000 41.69097 ? 687 HOH B O     1 
HETATM 2247 O O     . HOH C 3 .   ? -70.03822 8.45647   -7.14411  1.000 49.17657 ? 688 HOH B O     1 
HETATM 2248 O O     . HOH C 3 .   ? -15.70549 3.78764   -2.94452  1.000 57.23765 ? 689 HOH B O     1 
HETATM 2249 O O     . HOH C 3 .   ? -60.47676 28.57970  -5.95602  1.000 41.88785 ? 690 HOH B O     1 
HETATM 2250 O O     . HOH C 3 .   ? -57.67103 32.42966  -6.05390  1.000 56.13930 ? 691 HOH B O     1 
HETATM 2251 O O     . HOH C 3 .   ? -17.07651 3.21903   -0.44361  1.000 56.81848 ? 692 HOH B O     1 
HETATM 2252 O O     . HOH C 3 .   ? -57.91164 -1.10272  -11.06326 1.000 49.23206 ? 693 HOH B O     1 
HETATM 2253 O O     . HOH C 3 .   ? -60.66293 27.16804  -8.72933  1.000 40.79308 ? 694 HOH B O     1 
HETATM 2254 O O     . HOH C 3 .   ? -42.17381 19.32280  -7.15371  1.000 51.13242 ? 695 HOH B O     1 
HETATM 2255 O O     . HOH C 3 .   ? -39.41796 10.47616  -12.85621 1.000 45.55253 ? 696 HOH B O     1 
HETATM 2256 O O     . HOH C 3 .   ? -72.14014 9.02607   -10.87347 1.000 48.48186 ? 697 HOH B O     1 
HETATM 2257 O O     . HOH C 3 .   ? -50.92248 7.76667   9.31460   1.000 54.22512 ? 698 HOH B O     1 
HETATM 2258 O O     . HOH C 3 .   ? -16.69457 -10.06210 -0.86639  1.000 62.82584 ? 699 HOH B O     1 
HETATM 2259 O O     . HOH C 3 .   ? -44.34838 -0.58252  -18.95631 1.000 60.57443 ? 700 HOH B O     1 
HETATM 2260 O O     . HOH C 3 .   ? -52.03441 21.16127  -26.44999 1.000 55.64890 ? 701 HOH B O     1 
HETATM 2261 O O     . HOH C 3 .   ? -25.74564 6.00048   7.84469   1.000 51.38609 ? 702 HOH B O     1 
HETATM 2262 O O     . HOH C 3 .   ? -58.199   14.113    -20.321   1.000 48.75144 ? 703 HOH B O     1 
HETATM 2263 O O     . HOH C 3 .   ? -35.99719 11.69949  -17.98721 1.000 51.00991 ? 704 HOH B O     1 
HETATM 2264 O O     . HOH C 3 .   ? -33.937   17.696    -17.139   1.000 51.19249 ? 705 HOH B O     1 
HETATM 2265 O O     . HOH C 3 .   ? -50.35089 -4.03202  -6.98526  1.000 57.82637 ? 706 HOH B O     1 
HETATM 2266 O O     . HOH C 3 .   ? -31.254   15.027    -17.305   1.000 59.20279 ? 707 HOH B O     1 
HETATM 2267 O O     . HOH C 3 .   ? -52.91714 17.09203  8.81257   1.000 51.23070 ? 708 HOH B O     1 
HETATM 2268 O O     . HOH C 3 .   ? -37.29580 7.69693   -0.54010  1.000 46.28376 ? 709 HOH B O     1 
HETATM 2269 O O     . HOH C 3 .   ? -66.18720 8.70789   -22.26752 1.000 57.78949 ? 710 HOH B O     1 
HETATM 2270 O O     . HOH C 3 .   ? -20.35140 -12.22709 0.02993   1.000 59.71981 ? 711 HOH B O     1 
HETATM 2271 O O     . HOH C 3 .   ? -31.48351 2.28582   -16.31365 1.000 46.09110 ? 712 HOH B O     1 
HETATM 2272 O O     . HOH C 3 .   ? -63.79350 5.71619   -13.06531 1.000 45.68977 ? 713 HOH B O     1 
HETATM 2273 O O     . HOH C 3 .   ? -36.362   10.135    -20.367   1.000 51.28781 ? 714 HOH B O     1 
HETATM 2274 O O     . HOH C 3 .   ? -47.47987 -3.02071  -11.96462 1.000 54.27756 ? 715 HOH B O     1 
HETATM 2275 O O     . HOH C 3 .   ? -60.84305 -0.10341  -14.82688 1.000 68.82257 ? 716 HOH B O     1 
HETATM 2276 O O     . HOH C 3 .   ? -21.50527 3.17867   -8.97603  1.000 67.21041 ? 717 HOH B O     1 
HETATM 2277 O O     . HOH C 3 .   ? -21.56717 1.15419   -8.85548  1.000 72.02402 ? 718 HOH B O     1 
# 
